cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Open Access Research Outputs Receive More Diverse Citations
Creators: name: Huang, Chun-Kai (Karl)
name: Neylon, Cameron
name: Montgomery, Lucy
name: Hosking, Richard
name: Diprose, James P.
name: Handcock, Rebecca N.
name: Wilson, Katie
Publisher: name: Zenodo
Year: 2023
Subjects: Open Access
Diversity
Citation
Usage
Repositories
Scholarly Publishing
Crossref
Microsoft Academic
Research Organization Registry

description: The goal of open access is to allow more people to read and use research outputs. An observed association between highly cited research outputs and open access has been claimed as evidence of increased usage of the research, but this remains controversial.1,2 A higher citation count also does not necessarily imply wider usage such as citations by authors from more places.3,4,5 A knowledge gap exists in our understanding of who gets to use open access research outputs and where users are located. Here we address this gap by examining the association between an output’s open access status and the diversity of research outputs that cite it. By analysing large-scale bibliographic data from 2010 to 2019, we found a robust association between open access and increased diversity of citation sources by institutions, countries, subregions, regions, and fields of research, across outputs with both high and medium-low citation counts. Open access through disciplinary or institutional repositories showed a stronger effect than open access via publisher platforms. This study adds a new perspective to our understanding of how citations can be used to explore the effects of open access. It also provides new evidence at global scale of the benefits of open access as a mechanism for widening the use of research and increasing the diversity of the communities that benefit from it.
(502932) Andrew Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Stimmung–Bild
Creators: name: Moretti, Giampiero
Publisher: name: Trópos
Year: 2014

description: Through the analysis of the concepts of Stimmung and Bild from a historical and philosophical viewpoint, the author analyses both concepts as attempts, worked out by the Western thought, to variously overcome, in poetic and artistic fields, the question of the “inside–out”, “soul and body” dualism and opposition. The most important references include Hölderlin, Schelling, Heidegger.
description: Trópos, V. 7 N. 1 (2014): Iconochiasmi. Interpretazioni dell’immagine, immagini dell’interpretazione
La finzione necessaria
Creators: name: Vercellone, Federico
Publisher: name: Trópos
Year: 2014

description: The birth of aesthetics with Baumgarten contains a promise of synaesthetic plenitude which is denied when aesthetics becomes philosophy of art in the 19th century. Thus we have moved towards a new status of aesthetics. With this transition the emphasis has been placed in particular on the separation of the different senses that we use when approaching every kind of art. Every art form will have one and only one sense with which to perceive it. And so is an abstract experience of art created. In other words, we have to do with an impoverished experience of art. Art has now become only a form of appearance because it has lost its own synaesthetic content. Modern art from the Romantics to the Avantgarde, including contemporary art with the new technologies, have constantly tried to break through these boundaries.
description: Trópos, V. 7 N. 1 (2014): Iconochiasmi. Interpretazioni dell’immagine, immagini dell’interpretazione
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
Creators: name: Baric, Ralph
name: Brunette, Natalie
name: Sprouse, Kaitlin R.
name: Pettie, Deleah
name: Ferrell, Douglas E.
name: Van Voorhis, Wesley C.
name: Hsieh, Ching-Lin
name: Schäfer, Alexandra
name: Clark, Matthew
name: Veesler, David
name: Miranda, Marcos C.
name: Pulendran, Bali
name: Ravichandran, Rashimi
name: O'Hagan, Derek T.
name: Navarro, Mary-Jane
name: Bowen, John
name: Tortorici, M. Alejandra
name: Kleanthous, Harry
name: Sydeman, Claire
name: Corti, Davide
name: Villinger, Francois
name: Bloom, Jesse
name: Wrenn, Samuel
name: Carter, Lauren
name: Arunachalam, Prabhu S.
name: Van Der Most, Robbert
name: Smith, Kelly D.
name: Rogers, Kenneth
name: Tilles, Sasha W.
name: Ogohara, Cassandra
name: Starr, Tyler
name: Martinez, David R.
name: Sheahan, Timothy P.
name: Greaney, Allison
name: Walls, Alexandra
name: O'Connor, Megan
name: Pham, Minh N.
name: Leist, Sarah R.
name: Fuller, Deborah J.
name: Fiala, Brooke
name: Kepl, Elizabeth
name: Shirreff, Lisa
name: Rappuoli, Rino
name: Blackstone, Alyssa
name: McLellan, Jason S.
name: Tisch, Roland
name: Zepeda, Samantha K.
name: Johnson, Max
name: King, Neal P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Understanding vaccine-elicited protection against SARS-CoV-2 variants and other sarbecoviruses is
key for guiding public health policies. We show that a clinical stage multivalent SARS-CoV-2 spike
receptor-binding domain nanoparticle vaccine (RBD-NP) protects mice from SARS-CoV-2 challenge
after a single immunization, indicating a potential dose-sparing strategy. We benchmarked serum
neutralizing activity elicited by RBD-NP in non-human primates against a lead prefusion-stabilized
SARS-CoV-2 spike (HexaPro) using a panel of circulating mutants. Polyclonal antibodies elicited by
both vaccines are similarly resilient to many RBD residue substitutions tested although mutations at
and surrounding position 484 have negative consequences for neutralization. Mosaic and cocktail
nanoparticle immunogens displaying multiple sarbecovirus RBDs elicit broad neutralizing activity in
mice and protect mice against SARS-CoV challenge even in the absence of SARS-CoV RBD in the
vaccine. This study provides proof of principle that multivalent sarbecovirus RBD-NPs induce
heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the
clinic.
Open Access Research Outputs Receive More Diverse Citations
Creators: name: Huang, Chun-Kai (Karl)
name: Neylon, Cameron
name: Montgomery, Lucy
name: Hosking, Richard
name: Diprose, James P.
name: Handcock, Rebecca N.
name: Wilson, Katie
Publisher: name: Zenodo
Year: 2022
Subjects: Open Access
Diversity
Citation
Usage
Repositories
Scholarly Publishing
Crossref
Microsoft Academic
Research Organization Registry

description: The goal of open access is to allow more people to read and use research outputs. An observed association between highly cited research outputs and open access has been claimed as evidence of increased usage of the research, but this remains controversial.1,2 A higher citation count also does not necessarily imply wider usage such as citations by authors from more places.3,4,5 A knowledge gap exists in our understanding of who gets to use open access research outputs and where users are located. Here we address this gap by examining the association between an output’s open access status and the diversity of research outputs that cite it. By analysing large-scale bibliographic data from 2010 to 2019, we found a robust association between open access and increased diversity of citation sources by institutions, countries, subregions, regions, and fields of research, across outputs with both high and medium-low citation counts. Open access through disciplinary or institutional repositories showed a stronger effect than open access via publisher platforms. This study adds a new perspective to our understanding of how citations can be used to explore the effects of open access. It also provides new evidence at global scale of the benefits of open access as a mechanism for widening the use of research and increasing the diversity of the communities that benefit from it.
(502933) William Weallens
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
De-Confinement in small systems: Clustering of color sources in high multiplicity $\bar{p}$p collisions at $\sqrt{s}$= 1.8 TeV
Creators: name: Gutay, L. G.
name: Hirsch, A. S.
name: Pajares, C.
name: Scharenberg, R. P.
name: Srivastava, B. K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is shown that de-confinement can be achieved in high multiplicity non jet $\bar{p}$p collisions at $\sqrt{s}$= 1.8 TeV Fermi National Accelerator Laboratory(FNAL- E735) experiment. Previously the evidence for de-confinement was the demonstrated by the constant freeze out energy density in high multiplicity events. In this paper we use the same data but analyze the transverse momentum spectrum in the framework of the clustering of color sources. The charged particle pseudorapidities densities in the range 7.0 $\leq \langle dN_{c}/dη\rangle \leq$26.0 are considered. Results are presented for both thermodynamic and transport properties. The initial temperature and energy density are obtained and compared with the Lattice Quantum Chromo Dynamics(LQCD) simulations. The energy density ($\varepsilon/T^{4}$) $\sim$ 11.5 for $ \langle dN_{c}/dη\rangle \sim $ 25.0 is close to the value for 0-10\% central events in Au+Au collisions at $\sqrt{s_{NN}}$= 200 GeV. The shear viscosity to entropy density ratio($η/s$) is $\sim$ 0.2 at the transition temperature. The result for the trace anomaly $Δ$ is in excellent agreement with LQCD simulations. These results confirm our earlier observation that the de-confined state of matter was created in high multiplicity events in $\bar{p}$p collisions at $\sqrt{s}$=1.8 TeV.
description: 7 pages, 5 figures
title: Synthesis of decentralized robust stabilizing control for the systems with parametric perturbations
title: Синтез децентрализованного робастного стабилизирующего управления системами с параметрическими возмущениями
Creators: name: Kozlov, Vladimir
name: Shashikhin, Vladimir
Publisher: name: Computing, Telecommunication and Control
Year: 2020
Subjects: робастное управление
крупномасштабные системы
параметрические возмущения
децентрализованная структура
функции Ляпунова–Разумихина
устойчивость с заданной степенью робастности
robust control
large-scale systems
parametric perturbations
decentralized structure
Lyapunov–Razumikhin functions
pre-assigned degree of robust stability

description: The paper considers the problem of robust stabilization of large-scale systems with parametric perturbations within set number intervals. Design of systems with robust properties is among the most important problems of control theory. It allows to describe dynamics of the initial object by a mathematical model using a vector differential equation with interval coefficients. The paper states the problem of synthesis of stabilizing control with a pre-assigned degree of robust stability for closed systems. Scalar optimization function and Lyapunov–Razumikhin function were used to identify many stabilizing regulators. Parameters of robust control regulators are determined by the solutions of two Riccati equations: the first one corresponding to the nominal parameters of the object and the second – to variations of the object parameters. Sufficient conditions for robust stability of the closed system are obtained.
description: Рассмотрена задача робастной стабилизации крупномасштабных систем с параметрическими возмущениями, которые лежат внутри заданных числовых промежутков. Проектирование систем с робастными свойствами является одной из важнейших задач теории автоматического управления. Это позволяет описывать динамику исходного объекта с помощью векторно-матричных дифференциальных уравнений с интервальными коэффициентами. Для класса замкнутых систем сформулирована задача синтеза стабилизирующего управления с заданной степенью робастной устойчивости. С использованием скалярно-оптимизационных функций и функций Ляпунова–Разумихина выделяется множество стабилизирующих регуляторов. Параметры регуляторов определяются решениями уравнения Риккати, связанного с номинальными параметрами объекта, и уравнения Риккати, составленного для вариаций параметров объекта. Получены достаточные условия существования управления, обеспечивающего робастную стабилизацию исходной системы. Замкнутая система имеет заданную степень робастной устойчивости.
The Pursuit of Happiness: A Calculation of the Hidden Costs of Being Black in the 21st Century
Creators: name: Smith, C.W.
name: Rubalcaba, J.A.A.
Publisher: name: SAGE Publications Inc.
Year: 2021

description: There is no shortage of evidence documenting glaring disparities on important socioeconomic and health indicators between White and Black Americans. Persistent racial disparities are the consequence of a historic system of structural racism. Given ongoing inequities in nearly every realm of American life, we aim to calculate the contemporary cost of racial inequity. We contribute to a growing body of literature concerning the “hidden cost” of being Black by employing a novel methodological approach and centering a paradigm of intersectionality (Crenshaw, 1991; Shapiro, 2004). Specifically, we account for the disparities in health and income between Blacks and Whites by using the compensating and equivalent surplus frameworks to calculate willingness to accept (WTA) and willingness to pay (WTP) estimates. We estimate the WTP to avoid the disparity in health, income, and wellbeing between Black and White Americans, to be between approximately $38,000 and $45,000 per year per person using the Behavioral Risk Factor Surveillance System as well as the General Social Survey, respectively. These estimates can be interpreted as the annual willingness to pay by an average White person to avoid the disparities in income and health experienced by the average Black person.
Evolutionary Artificial Neural Network Based on Chemical Reaction Optimization
Creators: name: Yu, James J. Q.
name: Lam, Albert Y. S.
name: Li, Victor O. K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Evolutionary algorithms (EAs) are very popular tools to design and evolve artificial neural networks (ANNs), especially to train them. These methods have advantages over the conventional backpropagation (BP) method because of their low computational requirement when searching in a large solution space. In this paper, we employ Chemical Reaction Optimization (CRO), a newly developed global optimization method, to replace BP in training neural networks. CRO is a population-based metaheuristics mimicking the transition of molecules and their interactions in a chemical reaction. Simulation results show that CRO outperforms many EA strategies commonly used to train neural networks.
The Resurgence of Medical Education in Sociology: A Return to Our Roots and an Agenda for the Future
Creators: name: Olsen, L.D.
name: Jenkins, T.M.
name: Hirshfield, L.E.
name: Vinson, A.H.
name: Underman, K.
Publisher: name: American Sociological Association
Year: 2021

description: From 1940 to 1980, studies of medical education were foundational to sociology, but attention shifted away from medical training in the late 1980s. Recently, there has been a marked return to this once pivotal topic, reflecting new questions and stakes. This article traces this resurgence by reviewing recent substantive research trends and setting the agenda for future research. We summarize four current research foci that reflect and critically map onto earlier projects in this subfield while driving theoretical development elsewhere in the larger discipline: (1) professional socialization, (2) knowledge regimes, (3) stratification within the profession, and (4) sociology of the field of medical education. We then offer six potential future directions where more research is needed: (1) inequalities in medical education, (2) socialization across the life course and new institutional forms of gatekeeping, (3) provider well-being, (4) globalization, (5) medical education as knowledge-based work, and (6) effects of the COVID-19 pandemic.
Introduzione
Creators: name: Brivio, Guido
Publisher: name: Trópos
Year: 2014

description: Se le immagini, un po’ come gli armoire à glace proustiani, hanno la caratteristica peculiare di essere gli unici oggetti in grado di riflettere altri oggetti, da quale posizione dovremo collocarci per poterli osservare? Questi enti dallo statuto speciale, attraverso cui va oggi innanzitutto e per lo più – e forse sempre più - il nostro rapporto col mondo, lanciano una sfida ininterrotta alla filosofia dell’interpretazione. Ripensare il regime delle immagini alla luce degli sviluppi attuali della teoria dell’interpretazione e rideclinare l’ermeneutica attraverso il confronto con il mondo delle immagini, in un gioco di specchi tutt’altro che metaforico, può costituire una sfida e una pietra di paragone, oggi, per l’ermeneutica come per la civiltà dell’immagine
description: Trópos, V. 7 N. 1 (2014): Iconochiasmi. Interpretazioni dell’immagine, immagini dell’interpretazione
Nonprescription Stimulant Use at a Public University: Students’ Motives, Experiences, and Guilt
Creators: name: Burnett, M.
name: Cook, C.
name: Kurtz-Costes, B.
Publisher: name: SAGE Publications Inc.
Year: 2021

description: We examined the use of nonmedical prescription stimulants (NPSs) among students (N = 1,208) at a large public university in southeastern United States. After students who had been prescribed stimulants had been removed from the sample, 202 of the remaining 1,067 students (i.e., 18.9%) reported having engaged in NPS use in their lifetime. NPS use was strongly associated with membership in Greek societies and with binge drinking behavior. NPS users overwhelmingly reported engagement in NPS use for academic rather than for recreational purposes, and as anticipated, NPS users with academic motives reported stronger academic benefits than NPS users with social/recreational motives. Reports of guilt were low, and frequent users reported less guilt than infrequent users. Implications for interventions are discussed.
Driving scenarios and environmental settings in simulator-based driving assessment systems for stroke: a systematic review
Creators: name: Chanmas, Gunt
name: Taveekitworachai, Pittawat
name: Paliyawan, Pujana
name: Thawonmas, Ramita
name: Thawonmas, Ruck
name: Nukoolkit, Chakarida
name: Dajpratham, Piyapat
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Rehabilitation and Therapy
subject: Medicine and Health Sciences
subject: driving assessment
subject: driving simulator
subject: stroke
subject: systematic review

description: This is a registration of the study protocol for the systematic review "Driving scenarios and environmental settings in simulator-based driving assessment systems for stroke: a systematic review".
Kron's method and cell complexes for magnetomotive and electromotive forces
Creators: name: Maurice, Olivier
name: Reineix, Alain
name: Durand, Philippe
name: Dubois, François
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: Starting from topological principles we first recall the elementary ones giving Kirchhoff's laws for current conservation. Using in a second step the properties of spaning tree, we show that currents are under one hypothesis intrinsically boundaries of surfaces flux. Naturally flux appears as the object from which the edge comes from. The current becomes the magnetomotive force (mmf) that creates the flux in the magnetostatic representation. Using a metric and an Hodge's operator, this flux creates an electromotive force (emf). This emf is finally linked with the current to give the fundamental tensor - or "metric" - of the Kron's tensorial analysis of networks. As it results in a link between currents of cycles (surface boundaries) and energy sources in the network, we propose to symbolize this cross talk using chords between cycles in the graph structure on which the topology is based. Starting then from energies relations we show that this metric is the Lagrange's operator of the circuit. But introducing moment space, the previous results can be extended to non local interactions as far field one. And to conclude, we use the same principle to create general relation of information exchange between networks as functors between categories.
description: 21 pages
COMT Genotype and Efficacy of Propranolol for TMD Pain: A Randomized Trial
Creators: name: Arbes, S.J., Jr
name: Fillingim, R.B.
name: Ohrbach, R.
name: Willis, J.
name: Hadgraft, H.
name: Tchivileva, I.E.
name: Slade, G.D.
Publisher: name: SAGE Publications Ltd
Year: 2021

description: Propranolol is a nonselective β-adrenergic receptor antagonist that is efficacious in reducing facial pain. There is evidence that its analgesic efficacy might be modified by variants of the catechol-O-methyltransferase (COMT) gene. We tested the hypothesis in a subset of 143 non-Hispanic Whites from a randomized controlled trial of patients with painful temporomandibular disorder (TMD). Patients were genotyped for rs4680, a single nucleotide polymorphism of COMT, and randomly allocated to either propranolol 60 mg twice daily or placebo. During the 9-wk follow-up period, patients recorded daily ratings of facial pain intensity and duration; the product was computed as an index of facial pain. Postbaseline change in the index at week 9 (the primary endpoint) was analyzed as a continuous variable and dichotomized at thresholds of ≥30% and ≥50% reduction. Mixed models for repeated measures tested for the genotype × treatment group interaction and estimated means, odds ratios (ORs), and 95% confidence limits (95% CLs) of efficacy within COMT genotypes assuming an additive genetic model. In secondary analysis, the cumulative response curves were plotted for dichotomized reductions ranging from ≥20% to ≥70%, and genotype differences in area under the curve percentages (%AUC) were calculated to signify efficacy. Mean index reduction did not differ significantly (P = 0.277) according to genotype, whereas the dichotomized ≥30% reduction revealed greater efficacy among G:G homozygotes (OR = 10.9, 95%CL = 2.4, 50.7) than among A:A homozygotes (OR = 0.8, 95%CL = 0.2, 3.2) with statistically significant interaction (P = 0.035). Cumulative response curves confirmed greater (P = 0.003) efficacy for G:G homozygotes (%AUC difference = 43.7, 95%CL = 15.4, 72.1) than for A:A homozygotes (%AUC difference = 6.5, 95%CL = -30.2, 43.2). The observed antagonistic effect of the A allele on propranolol’s efficacy was opposite the synergistic effect hypothesized a priori. This unexpected result highlights the need for better knowledge of COMT’s role in pain pathogenesis if the gene is to be used for precision-medicine treatment of TMD (ClinicalTrials.gov NCT02437383).
(502887) William Darcy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Distinct Microbial Signatures between Periodontal Profile Classes
Creators: name: Ribeiro, A.A.
name: Webster-Cyriaque, J.
name: Styner, M.
name: Teles, F.R.
name: Beck, J.
name: Moss, K.
name: Marchesan, J.T.
name: Divaris, K.
name: Morelli, T.
Publisher: name: SAGE Publications Inc.
Year: 2021

description: Precise classification of periodontal disease has been the objective of concerted efforts and has led to the introduction of new consensus-based and data-driven classifications. The purpose of this study was to characterize the microbiological signatures of a latent class analysis (LCA)–derived periodontal stratification system, the Periodontal Profile Class (PPC) taxonomy. We used demographic, microbial (subgingival biofilm composition), and immunological data (serum IgG antibody levels, obtained with checkerboard immunoblotting technique) for 1,450 adult participants of the Dental Atherosclerosis Risk in Communities (ARIC) study, with already generated PPC classifications. Analyses relied on t tests and generalized linear models with Bonferroni correction. Men and African Americans had higher systemic antibody levels against most microorganisms compared to women and Caucasians (P < 0.05). Healthy individuals (PPC-I) had low levels of biofilm bacteria and serum IgG levels against most periodontal pathogens (P < 0.05). Subjects with mild to moderate disease (PPC-II to PPC-III) showed mild/moderate colonization of multiple biofilm pathogens. Individuals with severe disease (PPC-IV) had moderate/high levels of biofilm pathogens and antibody levels for orange/red complexes. High gingival index individuals (PPC-V) showed moderate/high levels of biofilm Campylobacter rectus and Aggregatibacter actinomycetemcomitans. Biofilm composition in individuals with reduced periodontium (PPC-VI) was similar to health but showed moderate to high antibody responses. Those with severe tooth loss (PPC-VII) had significantly high levels of multiple biofilm pathogens, while the systemic antibody response to these microorganisms was comparable to health. The results support a biologic basis for elevated risk for periodontal disease in men and African Americans. Periodontally healthy individuals showed a low biofilm pathogen and low systemic antibody burden. In the presence of PPC disease, a microbial-host imbalance characterized by higher microbial biofilm colonization and/or systemic IgG responses was identified. These results support the notion that subgroups identified by the PPC system present distinct microbial profiles and may be useful in designing future precise biological treatment interventions.
Sharpin is a key regulator of skeletal homeostasis in a TNF-dependent manner
Creators: name: McGowan, Heath
name: Schuijers, Johannes
name: Grills, Brian
name: McDonald, Stuart
name: Rickard, JA
name: Silke, John
name: McDonald, Aaron
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3208
subject: Medical physiology

description: Objectives: SHARPIN is a subunit of LUBAC and regulates activation of NF-κB, a pivotal transcription factor in skeletalhomeostasis. Mutated SHARPIN gene (cpdm) mice develop chronic proliferative dermatitis and systemic inflammation. Cpdmmice have an osteopaenic phenotype characterised by decreased cortical and trabecular bone volume, but whether this is a consequence of the hyper-inflammatory phenotype is unknown. The inflammatory phenotype of cpdm mice is prevented by Tnf deficiency so we examined cpdm. Tnf-/-mice to examine the role of SHARPIN in skeletal development. Methods: This research determined the extent to which SHARPIN and TNF interact within the skeleton through analyses of gene expression, μCT and biomechanical properties of bones of control (CTRL), cpdm, Tnf-/- (TNF KO) and cpdm. Tnf-/- (cpdm/TNF KO) mice. Results: Gene expression of IL-1β, TNF and caspase-3 increased in cpdm mice but was comparable to control values in cpdm/TNF KO mice. Decreased cortical and trabecular bone in cpdm mice translated to a loss in bone strength (ultimate stress and peak force).Cpdm/TNF KO mice developed bones similar to, or stronger than, control bones. Conclusions: Our results suggest that SHARPIN plays a significant role in skeletal homeostasis and that this role is strongly regulated through TNF pathways.
The cone of Betti tables over three non-collinear points in the plane
Creators: name: Gheorghita, Iulia
name: Sam, Steven V
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13D02, 13C05

description: We describe the cone of Betti tables of all finitely generated graded modules over the homogeneous coordinate ring of three non-collinear points in the projective plane. We also describe the cone of Betti tables of all finite length modules.
description: 7 pages
title: Facilitating Collaboration by Opening the Common Information Space in Mental Health Care
Creators: name: Hochwarter, Stefan
name: Schwarz, Julian
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: In this paper, we explore the role of common information space (CIS) in mental health care. CIS and collaboration have been prominent themes within the field of computer-supported cooperative work (CSCW). The study investigates two research questions: (i) How is CIS constructed and shared in mental health care? and (ii) How can CIS facilitate collaboration between health care workers and patients? We draw from a rich set of data from two separate research projects in the domain of mental health. The first project is on mental health home treatment, while the second project studies ...
title: Establishing a Health Data Marketplace: Insights from Stakeholder Interviews
Creators: name: Intaraphasuk, Kantasit
name: Erdvik, Magnus
name: Pappas, Ilias
name: Vassilakopoulou, Polyxeni
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: This study explores the potential establishment of a Health Data Marketplace in the Norwegian e-health sector by extending the capabilities of an existing health data platform. The findings are based on the analysis of interviews with key heathcare actors and point to key requisites for extending the data platform to a marketplace: developing a suitable Business Model, ensuring Data Standardization and Regualtory Compliance, providing Transparency and building Trust.
Real-Coded Chemical Reaction Optimization with Different Perturbation Functions
Creators: name: Yu, James J. Q.
name: Lam, Albert Y. S.
name: Li, Victor O. K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Chemical Reaction Optimization (CRO) is a powerful metaheuristic which mimics the interactions of molecules in chemical reactions to search for the global optimum. The perturbation function greatly influences the performance of CRO on solving different continuous problems. In this paper, we study four different probability distributions, namely, the Gaussian distribution, the Cauchy distribution, the exponential distribution, and a modified Rayleigh distribution, for the perturbation function of CRO. Different distributions have different impacts on the solutions. The distributions are tested by a set of well-known benchmark functions and simulation results show that problems with different characteristics have different preference on the distribution function. Our study gives guidelines to design CRO for different types of optimization problems.
title: AR in medical auscultation training
Creators: name: Götz, Susanne
name: Müller, Nicholas
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: The aim of the work "AR in medical auscultation training" is to use digital media to support and supplement medical knowledge transfer in the field of auscultation. The focus should be on the usefulness and supplementing, not replacing, teaching through digitalization. The prototype, which was created in practice, is intended to give aspiring physicians the opportunity to compensate for the lack of practice time in order to train their hearing.
Science for the Next Century: Deep Phenotyping
Creators: name: Herzberg, M.C.
name: Wright, J.T.
Publisher: name: SAGE Publications Inc.
Year: 2021

description: Our ability to unravel the mysteries of human health and disease have changed dramatically over the past 2 decades. Decoding health and disease has been facilitated by the recent availability of high-throughput genomics and multi-omics analyses and the companion tools of advanced informatics and computational science. Understanding of the human genome and its influence on phenotype continues to advance through genotyping large populations and using “light phenotyping” approaches in combination with smaller subsets of the population being evaluated using “deep phenotyping” approaches. Using our capability to integrate and jointly analyze genomic data with other multi-omic data, the knowledge of genotype-phenotype relationships and associated genetic pathways and functions is being advanced. Understanding genotype-phenotype relationships that discriminate human health from disease is speculated to facilitate predictive, precision health care and change modes of health care delivery. The American Association for Dental Research Fall Focused Symposium assembled experts to discuss how studies of genotype-phenotype relationships are illuminating the pathophysiology of craniofacial diseases and developmental biology. Although the breadth of the topic did not allow all areas of dental, oral, and craniofacial research to be addressed (e.g., cancer), the importance and power of integrating genomic, phenomic, and other -omic data are illustrated using a variety of examples. The 8 Fall Focused talks presented different methodological approaches for ascertaining study populations and evaluating population variance and phenotyping approaches. These advances are reviewed in this summary.
title: DoReMiND - A Robotic Application for Singing with Older Adults
Creators: name: Basoeki, Gloria Yap
name: Hille, Nora
name: Dunkel, Kyra Malinda
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: This work explores the possibilities of using a humanoid robot to support group singing activities for older adults in care facilities. The DoReMiND application was developed through an iterative design process involving user feedback and evaluation. The study successfully demonstrates that the robot can motivate older adults to sing, improving their well-being. However, challenges with voice recognition and group interactions were observed. The application’s potential to promote emotional well-being and the positive effects of music and robotic interaction on older adults show promise for ...
title: Mediating Personal Relationships with Robotic Pets for Fostering Human-Human Interaction of Older Adults
Creators: name: Du, Delong
name: Amirhajlou, Sara Gilda
name: Gyabaah, Akwasi
name: Paluch. Richard,
name: Müller, Claudia
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: Good human relationships are important for us to have a happy life and maintain our well-being. Otherwise, we will be at risk of experiencing loneliness or depression. In human-computer interaction (HCI) and computer-supported cooperative work (CSCW), robotic systems offer nuanced approaches to foster human connection, providing interaction beyond the traditional mediums that smartphones and computers offer. However, many existing studies primarily focus on the human-robot relationships that older adults form directly with robotic pets rather than exploring how these robotic pets can enhance ...
‘Respect’ and ‘justice’ for whom? Culturally irresponsive ethical practices with refugee communities
Creators: name: Bilotta, N.
Publisher: name: SAGE Publications Ltd
Year: 2021

description: This article explores how two common social work ethical principles, respect for persons and justice, are understood by refugee young people aged 18–30 years old in Kenya. Through 31 semi-structured, in-depth interviews with refugee young people who had previously participated in academic and/or organization-based qualitative research, this article explores how this group conceptualizes research ethics. The analysis suggests that refugee young people in Kenya did not necessarily feel that researchers were respectful. As such, the article claims that researchers must reconsider how Eurocentric social work and research ethics codes are understood globally.
Entanglement-enhanced two-photon delocalization in a coupled-cavity array
Creators: name: Tang, Shi-Qing
name: Yuan, Ji-Bing
name: Wang, Xin-Wen
name: Kuang, Le-Man
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study transport properties of two entangled photons which are initially injected into two nearest-neighbor coupling cavities in a one-dimensional coupled-cavity array (CCA). It is found that photonic transport dynamics in the two-photon CCA exhibits entanglement-enhanced two-photon delocalization (TPD) phenomenon. It is shown that the CCA can realize the localization-to-delocalization transition for two entangled photons.
description: 4 pages, 3 figures
title: Sink Twice – Research through Design to promote sustainable usage of water at your home
Creators: name: Firdaus, Hina
name: Laschke, Matthias
name: Müller, Claudia
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: The reusability and reconsideration of water usage in our homes may not be widely discussed, but even small efforts to conserve every drop of water can have a significant impact. Changing behavior in a context where individuals have constant access to water poses a challenge. In this study, we employ the Research through Design approach to investigate whether saving freshwater for reuse or re-purposing "not dirty" water in kitchens and bathrooms can lead to substantial savings in costs and carbon emissions associated with water filtration from sewage systems. The study involves five ...
(502882) Reginald Vanner Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Fibre and sex specific differences in mitochondrial content and subcellular distribution and morphology or lipid droplets in skeletal muscle biopsies obtained from lean, obese and type 2 diabetes patients.
Creators: name: Macey, M
Publisher: name: Liverpool John Moores University
Year: 2020

description: Intramuscular triglycerides (IMTG) are stored in lipid droplets (LD) in skeletal muscle, and it is thought that subcellular location, size and number of LDs relate to insulin sensitivity (IS) more so than IMTG content alone. Reduced expression and function of mitochondria has been implicated in the development of insulin resistance, leading to an accumulation of IMTG due to reduced oxidative capacity. The aim of the present study was to 1) establish a better understanding of the sex differences in the relationship between LD profile, mitochondrial density and the development of insulin resistance thereby 2) contributing to current and future research improving insulin sensitivity and preventing the progression of insulin resistance. The study investigated the hypothesis that 1) females have greater LD stores compared to males whilst maintaining insulin sensitivity, and 2) that type two diabetes (T2D) patients have greater LD stores compared to their lean and obese counterparts. Muscle biopsies were obtained from 48 male (n=24) and female (n=24) participants, categorised into groups (n=16/group) based on metabolic health; lean, obese and T2D. Cryosections (5μm) were stained using appropriate antibodies targeting myosin heavy chain I (MHC I) and MHC IIa. LDs were stained using bodipy 493/503 and mitochondria using mouse monoclonal anti-OxPhos complex IV (COXIV). Images were obtained using widefield and confocal fluorescence microscopy. In males, LD content was two-fold greater (P<0.05) within both the central and peripheral (5μm below cell membrane) regions of the type I and II fibres due to a two-fold increase in LD density (P<0.05) alongside larger LDs by one-fold (P<0.05) in comparison to females; thereby contradicting the first hypothesis. However, in agreement with the second hypothesis LD content was two-fold greater (P<0.05) in male T2D specifically within the central region of the type IIa fibres compared to the lean and obese males; primarily driven through larger LDs by one-fold (P<0.05). Furthermore, mitochondrial density followed a hierarchical distribution (TI>TII; P<0.001) in both males and females, with no differences observed between sexes or metabolic health status (P>0.05). In conclusion, this thesis presents novel data on sex differences in LD profile, mitochondrial density and insulin resistance and suggests a potential sex paradox; whereby reduced sex hormone production in post-menopausal females, alongside inactivity maybe more important determinants of insulin sensitivity than LD profile alone.
(502884) Elizabeth Ann Watmore
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Designing for Health, Engagement and Social-Interaction: A Multimodal and AR-based Sport System to facilitate digital Connectedness over Distances
Creators: name: Unbehaun, David
name: Ahmadi, Michael
name: Aal, Konstantin
name: Coskun, Aydin
name: Jensen, Jule
name: Wulf, Volker
name: Ellinger, Jan
name: Mall, Christoph
name: Meixner, Charlotte
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: This paper explores future opportunities for care through practice-based inter-ventions in real care settings and the use of design fiction as a method. Based on real innovation spaces within care-schools, we applied a design fiction approach to conceptualize and envision future care scenarios that include prototypical so-lutions for a digital transformation for both, people who in care contexts and people in need of care. We reflect on the content and implications of care fictions developed in collaboration with care-schools for shaping future systems of care and health in rural areas. With ...
Differential transcript usage analaysis for dynamic biological processes
Creators: name: Gilis, Jeroen
name: Van Den Berge, Koen
name: Clement, Lieven
Publisher: name: F1000 Research Limited
Year: 2022

description: Trajectory inference has been instrumental for modelling dynamic changes in biological systems. Downstream, a key challenge is the identification of biological markers. Our Bioconductor package tradeSeq performs differential expression tests for genes or transcripts, both within and between lineages. One drawback of tradeSeq is that it cannot directly test for differential transcript usage (DTU, the change in relative usage of transcripts within the same gene.) Several Bioconductor packages like DEXSeq, DRIMSeq and our package satuRn implement DTU tests, but are limited to comparisons between discrete groups of cells. Therefore, we here extend tradeSeq for testing DTU along trajectories. In addition, we provide powerful visualizations to inspect the differential transcript usage signal.
title: Head-Mounted Display-based Intervention and Education Concepts for Patients Post-Stroke and Relatives in Domestic Care
Creators: name: Meixner, Charlotte
name: Kükemück, Silke
name: Unbehaun, David
Publisher: name: European Society for Socially Embedded Technologies (EUSSET)
Year: 2023

description: This work presents a demonstration system that was developed as part of an interdisciplinary research project and aims to enhance health literacy and improve functional outcomes for patients post-stroke. The demonstration system consists of three parts: 1) a head-mounted Display and the connection to; 2) the electronic patient data management system and hospital information of the project partner. The system is able to initiate remote treatment and counselling, patient identification, remote mentoring, interactive control, and additional features like clinical assessment and documentation. ...
(502885) Elizabeth [Graham]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.