cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
3D-Cultured Vascular-Like Networks Enable Validation of Vascular Disruption Properties of Drugs In Vitro
Creators: name: Yavvari, Prabhusrinivas
name: Laporte, Anna
name: Elomaa, Laura
name: Schraufstetter, Fabian
name: Pacharzina, Inga
name: Daberkow, Aline Dominique
name: Hoppensack, Anke
name: Weinhart, Marie
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: vascular disruption
subject: antiangiogenesis
subject: sandwich assay
subject: lumen
subject: in vitro drug testing
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::547 Organische Chemie

description: Vascular-disrupting agents are an interesting class of anticancer compounds because of their combined mode of action in preventing new blood vessel formation and disruption of already existing vasculature in the immediate microenvironment of solid tumors. The validation of vascular disruption properties of these drugs in vitro is rarely addressed due to the lack of proper in vitro angiogenesis models comprising mature and long-lived vascular-like networks. We herein report an indirect coculture model of human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs) to form three-dimensional profuse vascular-like networks. HUVECs embedded and sandwiched in the collagen scaffold were cocultured with HDFs located outside the scaffold. The indirect coculture approach with the vascular endothelial growth factor (VEGF) producing HDFs triggered the formation of progressively maturing lumenized vascular-like networks of endothelial cells within less than 7 days, which have proven to be viably maintained in culture beyond day 21. Molecular weight-dependent Texas red-dextran permeability studies indicated high vascular barrier function of the generated networks. Their longevity allowed us to study the dose-dependent response upon treatment with the three known antiangiogenic and/or vascular disrupting agents brivanib, combretastatin A4 phosphate (CA4P), and 6´-sialylgalactose (SG) via semi-quantitative brightfield and qualitative confocal laser scanning microscopic (CLSM) image analysis. Compared to the reported data on in vivo efficacy of these drugs in terms of antiangiogenic and vascular disrupting effects, we observed similar trends with our 3D model, which are not reflected in conventional in vitro angiogenesis assays. High-vascular disruption under continuous treatment of the matured vascular-like network was observed at concentrations ≥3.5 ng·ml−1 for CA4P and ≥300 nM for brivanib. In contrast, SG failed to induce any significant vascular disruption in vitro. This advanced model of a 3D vascular-like network allows for testing single and combinational antiangiogenic and vascular disrupting effects with optimized dosing and may thus bridge the gap between the in vitro and in vivo experiments in validating hits from high-throughput screening. Moreover, the physiological 3D environment mimicking in vitro assay is not only highly relevant to in vivo studies linked to cancer but also to the field of tissue regeneration.
Zanclonychopus Sarjeant & Langston 1994
Creators: name: Abbassi, Nasrollah
name: Salehi Tinooni, Mohammad
name: Ghorbani Dehnavi, Mahdi
name: Shakeri, Safoora
name: Eshaghi, Ali
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Hyaenodonta
Zanclonychopus

description: IchnogenusZanclonychopusSarjeant & Langston, 1994
Type ichnospecies.
Zanclonychopus cinicalcator Sarjeant and Langston (1994).
Diagnosis.
Plantigrade footprints, with manus and pes of similar size and with all digits strongly clawed. Digits II to IV most deeply impressed and forming, with palm or sole, an approximately oval shape (more marked in the pes); digit I set off to one side and impressed lightly or not at all. Tips and claws of inner digits curving outward, of outer digits curving inward. Inner phalangeal pads of pes fused; those of manus free.
Discussion.
Sarjeant and Langston (1994) considered Creodonta as the trackmaker for Zanclonychopus, and compared it with American black bear for large footprints. The modern bears have large metatarsal and short metacarpal imprints with one pedal digit and distinctive long claws imprints. Zanclonychopus have the same sizes in the metatarsal and metacarpal imprints with long two to three pedal imprints. Exactly, Zanclonychopus differs from Ursichnus Diedrich (2011) by its position of digit I, shorter digit imprints and absence of claw imprints. Hirpexipes Sarjeant et al. (2002) is known as semidigitigrade to semiplantigrade footprints with all digits long and with sharp claws. Zanclonychopus has stocky and shorter digit imprints.
description: Published as part of Abbassi, Nasrollah, Salehi Tinooni, Mohammad, Ghorbani Dehnavi, Mahdi, Shakeri, Safoora & Eshaghi, Ali, 2024, Oligocene vertebrate footprints from the Lower Red Formation, Central Iran, pp. 265-287 in Fossil Record 27 (2) on pages 265-287, DOI: 10.3897/fr.27.133914
Efficacy and safety results from a randomized double-blind study comparing proposed biosimilar ABP 798 with rituximab reference product in subjects with moderate-to-severe rheumatoid arthritis
Creators: name: Burmester, Gerd
name: Drescher, Edit
name: Hrycaj, Pawel
name: Chien, David
name: Pan, Zhiying
name: Cohen, Stanley
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: ABP 798
subject: Biosimilar
subject: Efficacy
subject: Rituximab
subject: Safety
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background/objectives: ABP 798 is a proposed biosimilar to the originator biologic rituximab, an anti-CD20 monoclonal antibody. This comparative clinical study evaluated the pharmacokinetics (PK), safety, and efficacy of ABP 798 versus rituximab reference product (RP) in patients with moderate-to-severe rheumatoid arthritis (RA). Methods: Adults with moderate-to-severe RA with an inadequate response or intolerance to other disease-modifying anti-rheumatic drugs including 1 or more tumor necrosis factor inhibitor therapies (n = 311) received ABP 798, US-sourced rituximab RP (rituximab US), or EU-sourced rituximab RP (rituximab EU) (1000 mg, 2 weeks apart). At week 24, ABP 798- or rituximab EU-treated subjects received a second dose of the same treatment, while rituximab US-treated subjects transitioned to receive ABP 798. The key efficacy endpoint was DAS28-CRP change from baseline at week 24. Other efficacy endpoints included DAS28-CRP at other time points; ACR20, ACR50, and ACR70 criteria; and hybrid ACR. The rituximab RP groups were pooled for all efficacy endpoints since PK equivalence had been established between rituximab US and rituximab EU. Results: Clinical equivalence between ABP 798 and rituximab RP was established as the 90% confidence interval for DAS28-CRP change from baseline at week 24 fell within the prespecified equivalence margin (− 0.6, 0.6). Safety and immunogenicity profiles of ABP 798 were comparable across treatment groups and not affected by single transition from RP to ABP 798. Conclusions: Clinical equivalence in terms of efficacy, safety, and immunogenicity was established between ABP 798 and rituximab RP in this comparative clinical trial in patients with moderate-to-severe RA.
Impact of real-time angiographic co-registered optical coherence tomography on percutaneous coronary intervention: the OPTICO-integration II trial
Creators: name: Schneider, Vera S.
name: Böhm, Felix
name: Blum, Katharina
name: Riedel, Matthias
name: Abdelwahed, Youssef S.
name: Klotsche, Jens
name: Steiner, Julia K.
name: Heuberger, Andrea
name: Skurk, Carsten
name: Mochmann, Hans-Christian
name: Lauten, Alexander
name: Fröhlich, Georg
name: Rauch-Kröhnert, Ursula
name: Haghikia, Arash
name: Sinning, David
name: Stähli, Barbara E.
name: Landmesser, Ulf
name: Leistner, David M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: OCT
subject: Angiographic co-registration
subject: Geographic mismatch
subject: Edge dissection
subject: PCI
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aims: Longitudinal geographic mismatch (LGM) as well as edge dissections are associated with an increased risk of adverse events after percutaneous coronary intervention (PCI). Recently, a novel system of real-time optical coherence tomography (OCT) with angiographic co-registration (ACR) became available and allows matched integration of cross-sectional OCT images to angiography. The OPTICO-integration II trial sought to assess the impact of ACR for PCI planning on the risk of LGM and edge dissections. Methods: A total of 84 patients were prospectively randomized to ACR-guided PCI, OCT-guided PCI (without co-registration), and angiography-guided PCI. Primary endpoint was a composite of major edge dissection and/or LGM as assessed by post-PCI OCT. Results: The primary endpoint was significantly reduced in ACR-guided PCI (4.2%) as compared to OCT-guided PCI (19.1%; p = 0.03) and angiography-guided PCI (25.5%; p < 0.01). Rates of LGM were 4.2%, 17.0%, and 22.9% in the ACR-guided PCI, in the OCT-guided PCI, and the angiography-guided PCI groups, respectively (ACR vs. OCT p = 0.04; ACR vs. angiography p = 0.04). The number of major edge dissections was low and without significant differences among the study groups (0% vs. 2.1% vs. 4.3%). Conclusion: This study for the first time demonstrates superiority of ACR-guided PCI over OCT- and angiography-guided PCI in reducing the composite endpoint of major edge dissection and LGM, which was meanly driven by a reduction of LGM.
PPARβ/δ at the crossroads of energy metabolism, mitochondrial quality control and redox balance
Creators: name: Palioura, Dimitra
name: Mellidis, Kyriakos
name: Mouchtouri, Eleni-Taxiarchia
name: Mavroidis, Manolis
name: Lazou, Antigone
Publisher: name: Journal of Biological Research - Thessaloniki
Year: 2022
Subjects: PPARβ/δ; metabolism; antioxidant defense; mitochondria quality control; cardiometabolic disorders

description: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), member of the PPAR subfamily of nuclear receptors, is highly expressed in tissues with high rates of oxidative metabolism, such as the heart, skeletal muscle and liver. PPARβ/δ exerts its transcriptional control by direct binding on specific response elements on target genes promoters with the help of cofactors resulting in transactivation or transrepression of multiple genes involved in energy metabolism, mitochondrial biogenesis, or antioxidant defense. Several pre-clinical studies have shown that reduced PPARβ/δ expression in the heart is associated with diminished cardiac performance, impaired contractility and relaxation and even decreased survival in cardiomyopathies with distinct aetiologies while ligand-mediated activation or overexpression of PPARβ/δ has been shown to be protective in the setting of ischemia/reperfusion injury and several types of cardiomyopathies (dilated, hypertrophic or diabetic). PPARβ/δ stimulates fatty acid and glucose uptake as well as fatty acid oxidation but does not control triglyceride synthesis. In parallel, PPARβ/δ upregulates PGC1α, which is the critical regulator of mitochondrial biogenesis, and is also associated with mediators of mitochondrial fusion/fission and components of mitochondrial respiration. In addition, PPARβ/δ has been linked to multiple antioxidant defense mechanisms in the heart, including SOD1 and 2, Catalase, ALDH2 or NF-κB related pathways. Overall, this review summarizes the research data on the role of PPARβ/δ in the regulation of cardiac energy metabolism, antioxidant defense systems and mitochondrial quality control. Those data suggest the potential of PPARβ/δ activation as a therapeutic target for patients with cardiometabolic disorders.
description: Journal of Biological Research - Thessaloniki, Vol 29 (2022)
Controlled Synthesis Of Hierarchical Porous Ag3Po4 Microspheres Through Natural Template For Photocatalytic Applications
Creators: name: SubrataMandal
name: Ananthakrishnan, Rajakumar
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
A Comparative Study On In-Vitro Bioactivity Of Nano-Bioglass Synthesized Using Rice Husk And Teos Silica Sources
Creators: name: D. Durgalakshmi
name: P. Aruna
name: S. Ganesan
Publisher: name: Zenodo
Year: 2018

description: The talk presented at 29th Annual General Meeting Of Materials Research Society Of India And National Symposium On Advances In Functional And Exotic Materials.
Instrumental and Pavlovian Mechanisms in Alcohol Use Disorder
Creators: name: Doñamayor, Nuria
name: Ebrahimi, Claudia
name: Garbusow, Maria
name: Wedemeyer, Friederike
name: Schlagenhauf, Florian
name: Heinz, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Alcohol use disorder
subject: Habits
subject: Goal-directed control
subject: Pavlovian conditioning
subject: Pavlovian-to-instrumental transfer
subject: Humans
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: Current theories of alcohol use disorders (AUD) highlight the importance of Pavlovian and instrumental learning processes mainly based on preclinical animal studies. Here, we summarize available evidence for alterations of those processes in human participants with AUD with a focus on habitual versus goal-directed instrumental learning, Pavlovian conditioning, and Pavlovian-to-instrumental transfer (PIT) paradigms. Recent Findings: The balance between habitual and goal-directed control in AUD participants has been studied using outcome devaluation or sequential decision-making procedures, which have found some evidence of reduced goal-directed/model-based control, but little evidence for stronger habitual responding. The employed Pavlovian learning and PIT paradigms have shown considerable differences regarding experimental procedures, e.g., alcohol-related or conventional reinforcers or stimuli. Summary: While studies of basic learning processes in human participants with AUD support a role of Pavlovian and instrumental learning mechanisms in the development and maintenance of drug addiction, current studies are characterized by large variability regarding methodology, sample characteristics, and results, and translation from animal paradigms to human research remains challenging. Longitudinal approaches with reliable and ecologically valid paradigms of Pavlovian and instrumental processes, including alcohol-related cues and outcomes, are warranted and should be combined with state-of-the-art imaging techniques, computational approaches, and ecological momentary assessment methods.
Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools
Creators: name: Weinelt, Ferdinand Anton
name: Stegemann, Miriam Songa
name: Theloe, Anja
name: Pfäfflin, Frieder
name: Achterberg, Stephan
name: Weber, Franz
name: Dübel, Lucas
name: Mikolajewska, Agata
name: Uhrig, Alexander
name: Kiessling, Peggy
name: Huisinga, Wilhelm
name: Michelet, Robin
name: Hennig, Stefanie
name: Kloft, Charlotte
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: meropenem
subject: piperacillin/tazobactam
subject: antimicrobial stewardship
subject: critically ill
subject: antibiotics
subject: pharmacokinetic/pharmacodynamic
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets. To reliably achieve the targeted concentrations, dosing needs to be adjusted for renal function. We aimed to evaluate a meropenem and piperacillin/tazobactam monitoring program in intensive care unit (ICU) patients by assessing (i) the adequacy of locally selected empirical targets, (ii) if dosing is adequately adjusted for renal function and individual target, and (iii) if dosing is adjusted in target attainment (TA) failure. In a prospective, observational clinical trial of drug concentrations, relevant patient characteristics and microbiological data (pathogen, minimum inhibitory concentration (MIC)) for patients receiving meropenem or piperacillin/tazobactam treatment were collected. If the MIC value was available, a target range of 1–5 × MIC was selected for minimum drug concentrations of both drugs. If the MIC value was not available, 8–40 mg/L and 16–80 mg/L were selected as empirical target ranges for meropenem and piperacillin, respectively. A total of 356 meropenem and 216 piperacillin samples were collected from 108 and 96 ICU patients, respectively. The vast majority of observed MIC values was lower than the empirical target (meropenem: 90.0%, piperacillin: 93.9%), suggesting empirical target value reductions. TA was found to be low (meropenem: 35.7%, piperacillin 50.5%) with the lowest TA for severely impaired renal function (meropenem: 13.9%, piperacillin: 29.2%), and observed drug concentrations did not significantly differ between patients with different targets, indicating dosing was not adequately adjusted for renal function or target. Dosing adjustments were rare for both drugs (meropenem: 6.13%, piperacillin: 4.78%) and for meropenem irrespective of TA, revealing that concentration monitoring alone was insufficient to guide dosing adjustment. Empirical targets should regularly be assessed and adjusted based on local susceptibility data. To improve TA, scientific knowledge should be translated into easy-to-use dosing strategies guiding antibiotic dosing.
Barrier Perturbation in Porcine Peyer’s Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins
Creators: name: Droessler, Linda
name: Cornelius, Valeria
name: Boehm, Elisa
name: Stein, Laura
name: Brunner, Nora
name: Amasheh, Salah
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: epithelial barrier
subject: claudins
subject: inflammation
subject: peyer’s patch
subject: tight junction
subject: TNF
subject: TNFR
subject: ussing chamber
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::632 Schäden, Krankheiten, Schädlinge an Pflanzen

description: The proinflammatory cytokine tumor necrosis factor (TNF) has been described as one of the main mediators of intestinal inflammatory diseases, affecting the composition of tight junction (TJ) proteins and leading to a disruption of the epithelial barrier. An intact intestinal barrier is mandatory, because the follicle-associated epithelium of Peyer’s patches represents the first defense line of the intestinal immune system and ensures a controlled uptake of antigens from the gut lumen. In the current study, we have analyzed the detailed effects of TNF on the follicle-associated epithelium of porcine Peyer’s patches by applying the Ussing chamber technique. Epithelial tissue specimens of Peyer’s patches and the surrounding villus epithelium were mounted into conventional Ussing chambers and incubated with TNF for 10 h. The transepithelial resistance, representing epithelial barrier function of the tissue, was recorded. A reduction of transepithelial resistance was detected after 8 h in Peyer’s patch tissue specimens, whereas the villus epithelium was not significantly affected by TNF. Subsequent molecular analysis of TJ protein expression revealed a marked decrease of claudin-1 and -4, and an increase of claudin-2. In neighboring villus epithelium, no significant changes in the expression of TJ proteins could be shown. A strong increase of TNF receptor-2 (TNFR-2) could also be detected in Peyer’s patches, in agreement with the major role of this receptor in Peyer’s patches. Our findings were in accordance with changes detected by confocal laser scanning immunofluorescence microscopy. The regulation of TNF effects via myosin light chain kinase (MLCK) was analyzed in blocking experiments. Our detailed analysis is the first to show that TNF affects the barrier function of the follicle-associated epithelium of porcine Peyer’s patches but has no effects on the villus epithelium. These findings reveal not only the basic differences of epithelial barrier function between the two structures, but also the significance of Peyer’s patches as a primary mucosal immune defense.
An Analysis of the Teacher's and the Blind Student's Needs toward an English Instruction for the Blind in Thai Context
Creators: name: Jannok, Arnon
name: Suksan Suppasetseree
Publisher: name: Silpakorn University Research Innovation and Creativity Administration Office
Year: 2020
Subjects: Needs analysis
blind
disabilities
English teachingand learning

description: Humanities, Arts and Social Sciences Studies, 20, 2, 515-540
Zanclonychopus Sarjeant & Langston 1994
Creators: name: Abbassi, Nasrollah
name: Salehi Tinooni, Mohammad
name: Ghorbani Dehnavi, Mahdi
name: Shakeri, Safoora
name: Eshaghi, Ali
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Hyaenodonta
Zanclonychopus

description: IchnospeciesZanclonychopusisp.
Fig. 10
Material.
Two footprints of a trackway, molded by plaster (IFMI -688).
Description.
These footprints belong to manus and pes imprints of a trackway, preserved as convex hyporelief on the lower bedding plane of a large, thick slab of sandstone (Fig. 10 A – C). Half of the pes imprint is preserved, and the manus imprint is complete. Pes and manus are separated and do not overlap. Based on the size and depth of penetration, the smaller front footprint was considered as pes and the larger one behind as a manus imprint; usually, mammals have a larger manus footprint. The metatarsal / metacarpal are the deepest part of the footprints, and digit imprints are not clear in footprints; the claw imprints, however, are distinct as a drop-shape slightly curved with sharp tips (Fig. 10 D). Four digit and claw imprints are visible in the manus with an unclear digit V imprint. The pes imprint is not deeper than the manus and comprises unclear digit imprints (Fig. 10 E, F). It seems that trackway width is larger, and the manus has more inward orientation than the pes.
Discussion.
Zanclonychopus was recorded as a large carnivore footprint with monotypy and has not previously been reported outside of North America. The studied footprints from Deh Nar have indistinct digit imprints, but one side has inclined claw imprints that are clear. Based on the size and morphology of the studied footprints, Zanclonychopus is the nearest ichnogenus name for the Deh Nar footprints, and this is the first report of Zanclonychopus outside of North America.
description: Published as part of Abbassi, Nasrollah, Salehi Tinooni, Mohammad, Ghorbani Dehnavi, Mahdi, Shakeri, Safoora & Eshaghi, Ali, 2024, Oligocene vertebrate footprints from the Lower Red Formation, Central Iran, pp. 265-287 in Fossil Record 27 (2) on pages 265-287, DOI: 10.3897/fr.27.133914
Influence of the Gut Microbiome on Feed Intake of Farm Animals
Creators: name: Wessels, Anna Grete
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: appetite
subject: eating behavior
subject: farm animals
subject: feed intake
subject: intestine
subject: microbiome
subject: neurotransmitters
subject: physiology
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: With the advancement of microbiome research, the requirement to consider the intestinal microbiome as the “last organ” of an animal emerged. Through the production of metabolites and/or the stimulation of the host’s hormone and neurotransmitter synthesis, the gut microbiota can potentially affect the host’s eating behavior both long and short-term. Based on current evidence, the major mediators appear to be short-chain fatty acids (SCFA), peptide hormones such as peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), as well as the amino acid tryptophan with the associated neurotransmitter serotonin, dopamine and γ-Aminobutyrate (GABA). The influence appears to extend into central neuronal networks and the expression of taste receptors. An interconnection of metabolic processes with mechanisms of taste sensation suggests that the gut microbiota may even influence the sensations of their host. This review provides a summary of the current status of microbiome research in farm animals with respect to general appetite regulation and microbiota-related observations made on the influence on feed intake. This is briefly contrasted with the existing findings from research with rodent models in order to identify future research needs. Increasing our understanding of appetite regulation could improve the management of feed intake, feed frustration and anorexia related to unhealthy conditions in farm animals.
Mnemonic and Heuristic for Estimating Spin-only Magnetic Moments
Creators: name: Garcia, Edel
Publisher: name: figshare
Year: 2022
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: A mnemonic and heuristic for estimating spin-only magnetic moments of free atoms and ions, and based on a continued fractions algorithm, are presented. Chemistry teachers and students might find these useful as problem-solving strategies for lectures and test sessions where calculators might not be permitted or available.
Internal Communications Management: A Case Study of Krung Thai Bank Public Company Limited Head Office and Branches in Three Southern Border Provinces of Thailand
Creators: name: Porntikan Promphet
Publisher: name: Silpakorn University Research Innovation and Creativity Administration Office
Year: 2020
Subjects: Internal communications
Krung Thai Bank Public Company Limited
operational efficiency

description: Humanities, Arts and Social Sciences Studies, 20, 2, 541-559
Self-Representation and the Change of Position: The Role of Arab American Theater in the 21st Century
Creators: name: Sharma, Vibha
name: Chamaiporn Buddharat
name: Sha'ar, Mohammed Yassin Mohd Aba
Publisher: name: Silpakorn University Research Innovation and Creativity Administration Office
Year: 2020
Subjects: Arab American theater
counter-discourse
change of position
hyper-visible
self-representation
resistance

description: Humanities, Arts and Social Sciences Studies, 20, 2, 560-581
D-JRA2.1 Coupling Methods
Creators: name: Gehrke, Oliver
name: Lauss, Georg
name: Widl, Edmund
name: Rajkumar, Vetrivel
name: van der Meer, Arjen
name: Kontou, Alkistis
name: Paspatis, Alexandros
name: Vogel, Steffen
name: Tran The, Hoang
name: De Paola, Antonio
name: Syed, Mazheruddin
name: Zhiwang, Feng
name: Schwarz, Jan Sören
Publisher: name: The ERIGrid 2.0 Consortium
Year: 2023
Subjects: Coupling Methods
Research Infrastructure
Multi-Domain
Co-Simulation
Real-time Simulation
Hardware-in-the-Loop Experiments
Deliverable
European Union (EU)
H2020
Project
ERIGrid 2.0
GA 870620

description: This work related to improved and extended real-time and co-simulation as well as Hardware-in-the-loop experiments covers a broad range of different but related topics, with a common focus on the interconnection and integration of Research Infrastructure in the form of simulators as well as physical laboratory equipment applied to:

Multi-domain co-simulation,

Mixed continuous and event-based co-simulation,

Local and remote Hardware-in-the-loop testing,

Virtual interconnections of multiple physical laboratories, and

Virtual interconnections of multiple real-time simulators.

Due to the broad range of topics covered in the work plan and the large number of partners involved, it was necessary to start with a more precise definition of the work scope. For this purpose, a survey was made among partners, asking for interests and experiences in seven different topic areas to identify clusters with enough interest. The results were then compiled into a scoping proposal. An online workshop was held with all involved participants in order to formulate concrete research topics, and subsequently to define goals and intermediate steps for each of these topics.

The work related to multi-domain co-simulation aims at furthering the state-of-the-art in this field to enhance usability, flexibility, performance, standards compliance, and reproducibility of related approaches. Moreover, the work on real-time coupling and Hardware-in-the-loop-based testing aims at improving, analysing, and evolving methods and algorithms for coupling real-time systems – physical or simulated – with a particular focus on systems whose components are geographically distributed.

This report summarises related methods and tools developed in ERIGrid 2.0 focusing on concept development rather than implementation and proof-of-concept. The latter will be the subject of other, project-related reports.
Sip Creation And Ingest Of Records (Pilot Definition: Pilot 2)
Creators: name: Pettersen-Dahl, Terje
name: Groven, Arne-Kristian
name: Alföldi, István
name: Anderson, David
name: Anderson, Janet
Publisher: name: Zenodo
Year: 2018
Subjects: E-ARK
Pilot

description: This technical note sets out the definition of E-ARK Pilot 2: SIP Creation and Ingest of Records
Exechonella Canu & Bassler in Duvergier 1924
Creators: name: Cáceres-Chamizo, Julia P.
name: Sanner, Joann
name: Tilbrook, Kevin J.
name: Ostrovsky, Andrew N.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Bryozoa
Gymnolaemata
Cheilostomatida
Exechonellidae
Exechonella

description: Genus Exechonella Canu & Bassler in Duvergier, 1924
Type species: Cyclicopora? grandis Duvergier, 1921 Diagnosis. Colonies encrusting, predominantly unilaminar, but becoming bi- and multilaminar or erect in some species. Zooids large (length 0.6–1.6 mm), convex, oval or hexagonal, separated by deep grooves. Peristome from low, collar-like, to long, cylindrical. Primary orifice rounded or oval, often with angular poster and with inner lamina underlaying the anter wall and typically ending with paired condyles—lateral or distolateral. Frontal shield umbunuloid with numerous foramina, opened or covered with an external cuticular layer. Marginal pores always present around zooidal periphery, though not always obvious. Vertical zooidal walls (lateral and transverse) wide or narrow, represented by multiporous mural septula with communication pores arranged in one or several rows. Adventitious avicularia generally present, being associated with lateralmost foramina, which are often larger than the rest of the foramina. Avicularia predominantly oval or round, with a small opening in the nipple or button-like central part but, occasionally, triangular in shape with a cross-bar. Some species have adventitious kenozooids, with a porous frontal wall, that are often associated with lateral avicularia. No ovicells, embryos are incubated in the internal brood sacs. Ancestrula is autozooidal in shape.
description: Published as part of Cáceres-Chamizo, Julia P., Sanner, Joann, Tilbrook, Kevin J. & Ostrovsky, Andrew N., 2017, Revision of the Recent species of Exechonella Canu & Bassler in Duvergier, 1924 and Actisecos Canu & Bassler, 1927 (Bryozoa, Cheilostomata): systematics, biogeography and evolutionary trends in skeletal morphology, pp. 1-79 in Zootaxa 4305 (1) on page 5, DOI: 10.11646/zootaxa.4305.1.1, http://zenodo.org/record/842587
Prospects of Genetics and Epigenetics of Alcohol Use Disorder
Creators: name: Wedemeyer, Friederike
name: Kaminski, Jakob A.
name: Zillich, Lea
name: Hall, Alisha S. M.
name: Friedel, Eva
name: Witt, Stephanie H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Alcohol use disorder
subject: Addiction
subject: Genetics
subject: FOS: Biological sciences
subject: Epigenetics
subject: Neurobiology
subject: Personalized medicine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: In this study, we illustrate recent findings regarding the genetics and epigenetics of alcohol use disorder (AUD). We further outline the future direction of genetic and epigenetic research in AUD. Recent Findings: Recent genome- and epigenome-wide studies allow new insight into genetic and epigenetic variation associated with AUD. The largest EWAS of AUD so far/to date found evidence for altered glucocorticoid receptor regulation. Longitudinal studies provide insight into the dynamics of the disease. Analyses of postmortem brain tissue reveal the impact of chronic alcohol consumption on DNA methylation in the brain. Summary: Genetic and environmental factors-mediated via epigenetic mechanisms-play an important role in AUD. Although knowledge of the biological underpinnings of AUD is still limited, ongoing research will ultimately lead to the development of biomarkers for disease classification, course of disease, and treatment response to support personalized medicine in the future.
The Influence of External Cultures on Art, Music, and Dance Education Students: A Case Study of Thailand and Lao PDR
Creators: name: Yootthana Chuppunnarat
name: Khanobbhorn Sangvanich
name: Vitchatalum Laovanich
name: Malinee Achayutthakan
name: Skowrung Saibunmi
name: Weerakit Suwanphithak
Publisher: name: Silpakorn University Research Innovation and Creativity Administration Office
Year: 2020
Subjects: Cultural invasion
art education
music education
dance education

description: Humanities, Arts and Social Sciences Studies, 20, 2, 582-603
Low-density Lipoprotein-Cholesterol Lowering Strategies for Prevention of Atherosclerotic Cardiovascular Disease: Focus on siRNA Treatment Targeting PCSK9 (Inclisiran)
Creators: name: Sinning, David
name: Landmesser, Ulf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: siRNA
subject: Hypercholesterolemia
subject: LDL-C
subject: PCSK9
subject: Coronary disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: The aim of low-density lipoprotein-cholesterol (LDL-C) lowering therapies is to safely achieve a consistent and long-term reduction in exposure of the vasculature to atherogenic lipoproteins in order to reduce the risk of atherosclerotic cardiovascular (CV) disease and the associated CV events, such as myocardial infarctions and ischemic strokes. This review summarizes the concept and clinical development of a novel molecular approach to efficiently lower LDL-C, a synthetic small interfering ribonucleic acid (siRNA)—inclisiran—directed against proprotein convertase subtilisin-kexin type 9 (PCSK9). Recent Findings: The understanding of genes regulating atherogenic lipoproteins and their causal role in the development of atherosclerotic CV disease has substantially advanced over the past years. This has opened the possibility for development of molecular therapies targeting these atherogenic lipoproteins, in particular by RNA-targeted treatment approaches. The most advanced clinical development program is the siRNA-treatment targeting PCSK9 (inclisiran), involving more than 4000 patients in clinical studies. Phase 1 and 2 studies have identified the dose of 300 mg inclisiran for efficient LDL-C lowering. Most recently, three phase 3 studies demonstrated that a regimen of inclisiran every 6 months was feasible and reduced LDL-C by approximately 50% in patients at high or very high CV risk or with familial hypercholesterolemia. Adverse events were similar in the inclisiran and the placebo groups, except for more frequent transient injection site reactions with inclisiran than with placebo. Summary: siRNA therapy targeting PCSK9 (inclisiran) applied twice a year efficiently reduced LDL-C by approximately 50% and was safe in recent phase 3 studies. The effects of this treatment on CV outcome are currently further assessed in a large ongoing CV outcome trial.
Dataset of tweets from candidates' and newspapers' tweeting activity during Nigeria's 2019 presidential campaign
Creators: name: Ahmad, Muhammad Auwal
Publisher: name: figshare
Year: 2022
Subjects: Uncategorized

description: Dataset embodies raw tweets collected from the verified Twitter accounts of President Muhammad Buhari of the All Progressives Congress (APC), Atiku Abubakar of the Peoples Democratic Party (PDP), and Twitter news posts of Daily Trust, The Punch, and Vanguard newspapers shared during the four months (Nov. 2018 to Feb. 2019) period of Nigeria's 2019 presidential campaign.
 The following Twitter handles: @MBuhari, @atiku, @daily_trust, @MobilePunch, and @vanguardngrnews were monitored for data sourcing.
 Data were systematically collected using a combination of Twitter Advanced Search API and two Google Chrome extensions, iMacros (personal edition) and FireShot (lite version), which enabled the archiving in portable document format (PDF) for easy reference.
Reducing the Toxicity of Long-Term Glucocorticoid Treatment in Large Vessel Vasculitis
Creators: name: Palmowski, Andriko
name: Buttgereit, Frank
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Glucocorticoids
subject: Large vessel vasculitis
subject: Adverse events
subject: Takayasu arteritis
subject: Giant cell arteritis
subject: Prednisone
subject: Steroids
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: While glucocorticoids (GCs) are effective in large vessel vasculitis (LVV), they may cause serious adverse events (AEs), especially if taken for longer durations and at higher doses. Unfortunately, patients suffering from LVV often need long-term treatment with GCs; therefore, toxicity needs to be expected and countered. Recent Findings: GCs remain the mainstay of therapy for both giant cell arteritis and Takayasu arteritis. In order to minimize their toxicity, the following strategies should be considered: GC tapering, administration of conventional synthetic (e.g., methotrexate) or biologic (e.g., tocilizumab) GC-sparing agents, as well as monitoring, prophylaxis, and treatment of GC-related AEs. Several drugs are currently under investigation to expand the armamentarium for the treatment of LVV. Summary: GC treatment in LVV is effective but associated with toxicity. Strategies to minimize this toxicity should be applied when treating patients suffering from LVV.
Sapovaccarin-S1 and -S2, Two Type I RIP Isoforms from the Seeds of Saponaria vaccaria L.
Creators: name: Schlaak, Louisa
name: Weise, Christoph
name: Kuropka, Benno
name: Weng, Alexander
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: plant toxin
subject: ribosome-inactivating protein (RIP)
subject: type I RIP
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Type I ribosome-inactivating proteins (RIPs) are plant toxins that inhibit protein synthesis by exerting rRNA N-glycosylase activity (EC 3.2.2.22). Due to the lack of a cell-binding domain, type I RIPs are not target cell-specific. However once linked to antibodies, so called immunotoxins, they are promising candidates for targeted anti-cancer therapy. In this study, sapovaccarin-S1 and -S2, two newly identified type I RIP isoforms differing in only one amino acid, were isolated from the seeds of Saponaria vaccaria L. Sapovaccarin-S1 and -S2 were purified using ammonium sulfate precipitation and subsequent cation exchange chromatography. The determined molecular masses of 28,763 Da and 28,793 Da are in the mass range typical for type I RIPs and the identified amino acid sequences are homologous to known type I RIPs such as dianthin 30 and saporin-S6 (79% sequence identity each). Sapovaccarin-S1 and -S2 showed adenine-releasing activity and induced cell death in Huh-7 cells. In comparison to other type I RIPs, sapovaccarin-S1 and -S2 exhibited a higher thermostability as shown by nano-differential scanning calorimetry. These results suggest that sapovaccarin-S1 and -S2 would be optimal candidates for targeted anti-cancer therapy.
Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
Creators: name: Schilrreff, Priscila
name: Alexiev, Ulrike
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: chronic wounds
subject: immunity
subject: inflammation
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to immune regulation. The dysregulation of the immune system leads to continuing inflammation and impaired wound healing and, subsequently, to chronic skin wounds. In this review, we discuss the role of the immune system, the involvement of inflammatory mediators and reactive oxygen species, the complication of bacterial infections in chronic wound healing, and the still-underexplored potential of natural bioactive compounds in wound treatment. We focus on natural compounds with antioxidant, anti-inflammatory, and antibacterial activities and their mechanisms of action, as well as on recent wound treatments and therapeutic advancements capitalizing on nanotechnology or new biomaterial platforms.
International Conference on Economics, Business, Tourism & Social Sciences [ICEBTS-2022] Bandung, Indonesia (and Online)
Creators: name: IIARP Conference & Publications
Publisher: name: Zenodo
Year: 2022

description: The ICEBTS 2022 is the premier interdisciplinary forum for students, research scholars, professors, Engineers, academicians & scientists to present their latest research results, ideas, developments, and applications from various social sciences and business-related fields. The conference will bring together leading academic scientists, researchers and scholars in the domain of interest from around the world.
Molecular Dynamics of DHHC20 Acyltransferase Suggests Principles of Lipid and Protein Substrate Selectivity
Creators: name: Panina, Irina
name: Krylov, Nikolay
name: Gadalla, Mohamed Rasheed
name: Aliper, Elena
name: Kordyukova, Larisa
name: Veit, Michael
name: Chugunov, Anton
name: Efremov, Roman
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: DHHC-PATs
subject: S-acylation
subject: palmitoylation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Lipid modification of viral proteins with fatty acids of different lengths (S-acylation) is crucial for virus pathogenesis. The reaction is catalyzed by members of the DHHC family and proceeds in two steps: the autoacylation is followed by the acyl chain transfer onto protein substrates. The crystal structure of human DHHC20 (hDHHC20), an enzyme involved in the acylation of S-protein of SARS-CoV-2, revealed that the acyl chain may be inserted into a hydrophobic cavity formed by four transmembrane (TM) α-helices. To test this model, we used molecular dynamics of membrane-embedded hDHHC20 and its mutants either in the absence or presence of various acyl-CoAs. We found that among a range of acyl chain lengths probed only C16 adopts a conformation suitable for hDHHC20 autoacylation. This specificity is altered if the small or bulky residues at the cavity’s ceiling are exchanged, e.g., the V185G mutant obtains strong preferences for binding C18. Surprisingly, an unusual hydrophilic ridge was found in TM helix 4 of hDHHC20, and the responsive hydrophilic patch supposedly involved in association was found in the 3D model of the S-protein TM-domain trimer. Finally, the exchange of critical Thr and Ser residues in the spike led to a significant decrease in its S-acylation. Our data allow further development of peptide/lipid-based inhibitors of hDHHC20 that might impede replication of Corona- and other enveloped viruses.
Nigerias_2019_presidential_campaign_ Set_of_tweet_and_news_tweet.zip
Creators: name: Ahmad, Muhammad Auwal
Publisher: name: figshare
Year: 2022
Subjects: Uncategorized

description: Dataset embodies raw tweets collected from the verified Twitter accounts of President Muhammad Buhari of the All Progressives Congress (APC), Atiku Abubakar of the Peoples Democratic Party (PDP), and Twitter news post of Daily Trust, The Punch and Vanguard newspapers shared during four months period of Nigeria's 2019 presidential campaign.
 The following Twitter handles: @MBuhari, @atiku, @daily_trust, @MobilePunch and @vanguardngrnews were monitored for data sourcing.
 Data were collected through the Twitter API and arhived in portable document format (PDF) for easy reference.
Análisis del Movimiento Oscilatorio
Creators: name: Bueno-Pascual, Felix Eduardo
name: López-Mariño, Miguel Angel
Publisher: name: figshare
Year: 2022
Subjects: subject: 20501 Classical and Physical Optics
subject: FOS: Physical sciences

description: Aprovechamos las capacidades de Maple en la modelación del movimiento tanto armónico simple como amortiguado; incluimos el caso del péndulo lineal y del no lineal. El paquete nos ofrece la posiblidad de presentar los resultados obtenidos en forma numérica, simbólica y gráfica. Comparamos nuestras soluciones con las obtenidas por aproximación numérica usando otra herramienta.
A High-Energy Diet and Spirulina Supplementation during Pre-Gestation, Gestation, and Lactation do Not Affect the Reproductive and Lactational Performance of Primiparous Sows
Creators: name: Lugarà, Rosamaria
name: Grześkowiak, Łukasz
name: Zentek, Jürgen
name: Meese, Susanne
name: Kreuzer, Michael
name: Giller, Katrin
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: primiparous sow
subject: dietary fat
subject: microalga
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Feeding high-energy (HED) or high-fat diets during gestation and lactation to pigs may help cover the energy requirements of high-prolific sows but may also adversely affect their reproductive performance. The microalga Arthrospira plantensis (Sp), rich in bioactive compounds, has been described to exert beneficial health effects. The present study investigated the effects of HED and Sp intake during gestation and lactation in pigs. Twenty-four primiparous crossbred sows were fed either a HED or a control diet. Half of the sows per group were supplemented with 20 g/day of Sp. Despite a higher gross energy intake, consuming the HED did not affect the sows’ reproductive and lactational performance but significantly modified the colostrum fatty acid (FA) composition and tended to decrease the number of weaned piglets. The Sp supplementation did not affect the reproduction and lactation traits, but slightly affected the colostrum FA composition. A trend was observed for an interaction of diet and Sp in terms of offspring sex ratio with a 50% lower male-to-female ratio in the HED group compared to all other animals. These findings suggest that an HED and Sp intake hardly influence reproduction in sows. However, the HED modified the colostrum FA composition, whereas the Sp had only fewer effects, which may potentially affect offspring performance.
Éviter le binage dans le colza biologique
Creators: name: Dierauer, Hansueli
name: Niggli, Jeremias
name: Gelencsér, Tobias
Publisher: name: Zenodo
Year: 2022
Subjects: DiverIMPACTSPA
Gestion des mauvaises herbes
qualité et fertilité des sols

description: Problème : Le colza oléagineux semé en été ne forme un couvert dense qu’au printemps suivant. En automne et en hiver, les peuplements peuvent être infestés de mauvaises herbes, et dans les zones vulnérables, une érosion du sol peut se produire. Solution : Le sous-semis permet d’augmenter la couverture du sol à l’automne et ainsi de prévenir la levée et le développement des mauvaises herbes. Dans le cas du colza, les légumineuses sensibles au gel sont les mieux adaptées au sous-semis. Elles fixent l’azote et contribuent ainsi, par minéralisation, à couvrir les besoins importants en azote du colza. Après leur dépérissement en hiver, elles forment une couche fine de paillis sur le sol.