cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Dirichlet Problem with Prescribed Asymptotic Singularities
Creators: name: Harvey, F. Reese
name: Lawson, H. Blaine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 35J25, 35J70, 32U35

description: We solve the nonlinear Dirichlet problem (uniquely) for functions with prescribed asymptotic singularities at a finite number of points, and with arbitrary continuous boundary data, on a domain in euclidean space. The main results apply, in particular, to subequations with a Riesz characteristic $p \geq 2$. In this case it is shown that, without requiring uniform ellipticity, the Dirichlet problem can be solved uniquely for arbitrary continuous boundary data with singularities asymptotic to the Riesz kernel: $Θ_j K_p(x - x_j)$, where $K_p(x) = - {1\over|x|^{p-2}}$ for $p>2$ and $K_2(x) = \log |x|$, at any prescribed finite set of points $x_1,...,x_k$ in the domain and any finite set of positive real numbers $Θ_1,..., Θ_k$. This sharpens a previous result of the authors concerning the discreteness of high-density sets of subsolutions. Uniqueness and existence results are also established for finite-type singularities such as $Θ_j |x - x_j|^{2-p}$ for $1\leq p<2$. The main results apply similarly with prescribed singularities asymptotic to the fundamental solutions of Armstrong-Sirakov-Smart (in the uniformly elliptic case).
description: Material has been added concerning the Dirichlet Problem with prescribed values at marked interior points when the Riesz characteristic is strictly between 1 and 2
(107) John Campbell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia
Creators: name: Paradiso, A. M
name: Boucher, R. C
name: Coakley, R. D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The polarized distribution of HCO3− transport was investigated in human nasal epithelial cells from normal and cystic fibrosis (CF) tissues. To test for HCO3− transport via conductive versus electroneutral Cl−/HCO3− exchange (anion exchange, AE) pathways, nasal cells were loaded with the pH probe 2′,7′-bis(carboxyethyl)-5(6)-carboxyfluorescein and mounted in a bilateral perfusion chamber. In normal, but not CF, epithelia, replacing mucosal Cl− with gluconate caused intracellular pH (pHi) to increase, and the initial rates (ΔpH min−1) of this increase were modestly augmented (∼26 %) when normal cells were pretreated with forskolin (10 μm). Recovery from this alkaline shift was dependent on mucosal Cl−, was insensitive to the AE inhibitor 4,4′-diisothiocyanatodihydrostilbene-2,2′-disulfonic acid (H2DIDS; 1.5 mm), but was sensitive to the cystic fibrosis transmembrane conductance regulator (CFTR) channel inhibitor diphenylamine-2-carboxylate (DPC; 100 μm). In contrast, removal of serosal Cl− caused pHi to alkalinize in both normal and CF epithelia. Recovery from this alkaline challenge was dependent on serosal Cl− and blocked by H2DIDS. Additional studies showed that serosally applied Ba2+ (5.0 mm) in normal, but not CF, cells induced influx of HCO3− across the apical membrane that was reversibly blocked by mucosal DPC. In a final series of studies, normal and CF cells acutely alkaline loaded by replacing bilateral Krebs bicarbonate Ringer (KBR) with Hepes-buffered Ringer solution exhibited basolateral, but not apical, recovery from an alkaline challenge that was dependent on Cl−, independent of Na+ and blocked by H2DIDS. We conclude that: (1) normal, but not CF, nasal epithelia have a constitutively active DPC-sensitive HCO3− influx/efflux pathway across the apical membrane of cells, consistent with the movement of HCO3− via CFTR; and (2) both normal and CF nasal epithelia have Na+-independent, H2DIDS-sensitive AE at their basolateral domain.
องค์ประกอบทางสถาปัตยกรรม การเรียนรู้รูปแบบของเจดีย์ แนวทางจัดทำองค์ความรู้เพื่อจัดทำสื่อดิจิทัลการเรียนรู้ประวัติศาสตร์ศิลปะแนวใหม่ กรณีศึกษา : วัดเจดีย์เจ็ดแถว ศรีสัชนาลัย สุโขทัย
Creators: name: สุริยา รัตนะวงศ์กุล
name: สุชาติ เถาทอง
name: อติเทพ แจ้ดนาลาว
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2563
Subjects: วัดเจดีย์เจ็ดแถว
ความเป็นจริงเสริม
การเรียนรู้ประวัติศาสตร์ศิลปะแนวใหม่

description: วารสารมหาวิทยาลัยศิลปากร, 40, 2, 1.-22
Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia: Role of cyclic stress in airway mucociliary transport
Creators: name: Button, Brian
name: Picher, Maryse
name: Boucher, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: In the lungs, the first line of defence against bacterial infection is the thin layer of airway surface liquid (ASL) lining the airway surface. The superficial airway epithelium exhibits complex regulatory pathways that blend ion transport to adjust ASL volume to maintain proper mucociliary clearance (MCC). We hypothesized that stresses generated by airflow and transmural pressures during breathing govern ASL volume by regulating the rate of epithelial ATP release. Luminal ATP, via interactions with apical membrane P2-purinoceptors, regulates the balance of active ion secretion versus absorption to maintain ASL volume at optimal levels for MCC. In this study we tested the hypothesis that cyclic compressive stress (CCS), mimicking normal tidal breathing, regulates ASL volume in airway epithelia. Polarized tracheobronchial epithelial cultures from normal and cystic fibrosis (CF) subjects responded to a range of CCS by increasing the rate of ATP release. In normal airway epithelia, the CCS-induced increase in ASL ATP concentration was sufficient to induce purinoceptor-mediated increases in ASL height and MCC, via inhibition of epithelial Na+-channel-mediated Na+ absorption and stimulation of Cl− secretion through CFTR and the Ca2+-activated chloride channels. In contrast, static, non-oscillatory stress did not stimulate ATP release, ion transport or MCC, emphasizing the importance of rhythmic mechanical stress for airway defence. In CF airway cultures, which exhibit basal ASL depletion, CCS was partially effective, producing less ASL volume secretion than in normal cultures, but a level sufficient to restore MCC. The present data suggest that CCS may (1) regulate ASL volume in the normal lung and (2) improve clearance in the lungs of CF patients, potentially explaining the beneficial role of exercise in lung defence.
Technology acceptance within sustainable logistics of public health emergencies: a study of the UAE public health sector
Creators: name: Alzaabi, Mariam
Publisher: name: Anglia Ruskin Research Online (ARRO)
Year: 2024

description: This study critically examines the role of IoT technology acceptance in sustainable logistics during medical emergencies, considering individual and institutionally held norms in the UAE public sector. Sustainable logistics management of medical emergencies has been severely challenged, as evidenced by the COVID-19 global pandemic. The Ministry of Presidential Affairs (MoPA, UAE) in charge of pandemic management faced logistical challenges attributable to the size of resources, number of stakeholders involved, urgency and agility in managing medical emergencies. Questions of technology acceptance and innovation diffusion exist regarding the use of existing IoT blockchain technology infrastructure to address these challenges.The study considers the post-positivist research philosophy and the quantitative-deductive-survey research design, considering the population of all MoPA employees [n=1500] as well as stakeholder institutions [n=2000] related to medical logistics management under the auspices of MoPA. A sample of 347 was originally considered, following the stratified proportions sampling technique. The survey questionnaire was used as the primary data collection tool, and analysis followed the non-parametric structural equation modelling analytical technique with the help of IBM SPSS Statistics version 25 and SMART PLS version 4.As part of the first research question, findings reveal that both individual and organisational norms are instrumental to technology acceptance. With regard to the second research question, there is a generally acceptable level of readiness to accept IoT for medical emergencies despite the need for some improvements in the overall intention to use. Finally, results supporting the third research question reveal that intention and attitude positively influence sustainable logistics ‘economic’ performance.IoT blockchain technology holds the potential to revolutionise the economic efficiency of logistics management in medical emergencies. Evidence places it as critical to the optimization of UAE’s logistics management of future pandemics.
Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat: Silent spinal circuits speak up after SCI
Creators: name: Yang, Jing
name: Xiong, Lize
name: Zimmermann, Manfred
name: Zheng, Jihong
name: Lu, Yan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Most spinal cord injury (SCI) patients suffer from chronic pain. Effective therapy for this pain is lacking, and the underlying mechanisms are poorly understood. The spinal superficial dorsal horn (SDH) contains neuronal circuits capable of modulating primary afferent information involved in pain processing. KCC2 is an isoform of the K+–Cl− cotransporter that contributes to the regulation of transmembrane anion gradient which plays a key role in shaping GABAA receptor-mediated signalling in the CNS. We tested the hypothesis that SCI causes down-regulation of KCC2 distal to the injury and contributes to the neuronal hyperresponsiveness and pain-related behaviours. SCI was a hemisection at T13 level of adult Sprague–Dawley rats. Spinal sagittal slices with attached dorsal roots (DR) were prepared from L4 to L6 level. The reversal potentials of GABA responses (EGABA) and DR-evoked IPSPs and EPSPs of L4-6 SDH neurones in sham-operated and SCI rats were compared using gramicidin-perforated patch-clamp recordings. Here we report that thoracic SCI-induced down-regulation of KCC2 in the lumbar SDH parallels the development of allodynia. The subsequent changes of EGABA in SDH neurones attenuate the GABAA receptor-mediated inhibitory synaptic transmission. These changes cause certain normally subthreshold primary A and C fibre inputs to evoke action potential output in SDH neurones. We conclude that SCI induces KCC2 down-regulation and subsequent changes of EGABA in the SDH below the injury site. The resulting disinhibition unmasks normally ineffective SDH neuronal circuits and may contribute to the below-level central pain-related behaviours after incomplete SCI.
Supplementary information for: "A Novel Mutation in the FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure" by Zariñán et al. Revised version.
Creators: name: Zariñán, Teresa
name: Mayorga, Julio
name: Jardon-Valadez, Eduardo
name: Gutiérrez-Sagal, Rubén
name: Maravillas-Montero, José Luis
name: Mejía-Domínguez, Nancy R
name: Martínez-Luis, Iván
name: Yacini-Torres, Omar G.
name: Cravioto María Del Carmen
name: Reiter, Eric
name: Ulloa-Aguirre, Alfredo
Publisher: name: figshare
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Genetics
subject: FOS: Biological sciences

description: We herein show the revised version of Supplementary material corresponding to the study entitled "Molecular Physiopathogenesis of a Novel Mutant FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure. In Vivo, In Vitro, and In Silico Studies and Comparison with the Trafficking-Defective D408Y FSH Receptor.
(108) Mary W Forbes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Ambient Attitudes. On practices of contingency, treason and humour.
Creators: name: Schmitz, Edgar
Publisher: name: Goldsmiths, University of London
Year: 2009

description: Ambient Attitudes. On Practices of Contingency, Treason and Humour outlines post-critical modes of involvement in current artistic practice. The project intersects current philosophies of difference with post-critical contemporary arts practice and mobilizes their conjunction to set up new conceptual frameworks for emergent modes of (non-)engagement. Placing its investigative focus on contemporary artistic practice, the project is set against a broader crisis of representational relationships between theory and practice, and is embedded in questions around contemporary concepts of resistance (Antonio Negri, Paolo Virno) and the possibility of non- representational relationalities (Jean-Luc Nancy). For artistic and cultural practice as exemplary field, the project argues a move from specificity to contingency through Giorgio Agamben's notion of the whatever and Liam Gillick's early practice; it diagnoses slippage from trickery toward treason in Gilles Deleuze's notion of extended play and Gabriel Orozco's situational inserts; and it mobilises an attitudinal shift from irony to humour through Gilles Deleuze and Felix Guattari's notion of minority and Andreas Slominski's trap-settings. These moves are shown to overspill the limited and limiting economies of established critical models which cohere around implicit claims for sustainable exchanges between theory and practice: the critique of institutional and other specificities, trickster engagements with game-like structures and ironic responses to given situations are all invariably premised on representational assumptions about the ways in which situations and responses, gestures and conceptualisations relate. Against such models of reciprocity and as challenge to their coherence, Ambient Attitudes. On Practices of Contingency, Treason and Humour profiles practices which fuse a basic refusal to engage with an affirmation of productive encounters. Ambient dispersal as a new, fundamentally contingent milieu for contemporary practice and its articulation in qualities, effects and attitudes is thus argued to have a quasi-paradigmatic relevance for resistant practices at large, including any theoretical involvement with them.
(109) Isa Arnott Forbes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Formal Approach to Network/Distributed Systems Complex Testing
Creators: name: Shchurov, Andrey A.
name: Marik, Radek
name: Khlevnoy, Vladimir A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Deployment of network/distributed systems sets high requirements for procedures, tools and approaches for the complex testing of these systems. This work provides a survey of testing activities with regard to these systems based on standards and actual practices for both software-based and distribution (network) aspects. On the basis of this survey, we determine formal testing procedures/processes which cover these aspects, but which are not contrary to both aspects. The next step, based on the analysis of the implementation phase of System Development Life Cycle, determines a formal model for these processes
description: 5 pages, 1 figure
Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons
Creators: name: Liu, Wenhua
name: Yan, Zhen
name: Kafri, Tal
name: Yuen, Eunice Y
name: van Praag, Henriette
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Cofilin, the major actin depolymerizing factor, modulates actin dynamics that contribute to spine morphology, synaptic transmission and plasticity. Much evidence implicates the cofilin inactivation kinase LIMK in synaptic function, but little is known about the cofilin activation phosphatase Slingshot in this regard. In this study, we found that suppressing endogenous Slingshot with small RNA interference or function-blocking antibody led to a dramatic reduction of AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) in cortical neurons. Perturbation of Slingshot function also diminished the ability to express synaptic plasticity. Inactivating cofilin or disturbing actin dynamics reduced AMPAR-EPSCs in a Slingshot-dependent manner. Moreover, surface GluR 1 and synaptic GluR2/3 clusters were reduced by Slingshot knockdown. Our data suggest that Slingshot plays a pivotal role in AMPAR trafficking and synaptic transmission by controlling actin cytoskeleton via cofilin activation.
VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells
Creators: name: Hudson, Elizabeth J
name: Jones, Lisa C
name: Moussa, Lama
name: Lazarowski, Eduardo R
name: Kreda, Silvia M
name: Randell, Scott H
name: Zhu, Yunxiang
name: O'Neal, Wanda K
name: Fulcher, M Leslie
name: Boucher, Richard C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Mucin secretion in the lung is regulated by the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) exocytotic core, which has not been defined in airway goblet cells. In this study, the SNARE vesicle-associated membrane protein 8 (VAMP8) was found to be expressed in human airway epithelial goblet cells. VAMP8 knockdown by RNA interference techniques reduced airway epithelial mucin secretion induced by PAR agonists, neutrophil elastase and ATP. Basal (non-agonist elicited) mucin secretion was also reduced as a result of VAMP8 knockdown. Importantly, mucin secretion was reduced in the lungs of VAMP8 knockout mice compared to wild-type littermates. Our data suggest that VAMP8 is an essential SNARE in airway mucin granule exocytosis. Reduction of VAMP8 activity/expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases.
Metadynamics Surfing on Topology Barriers: the $CP^{N-1}$ Case
Creators: name: Laio, Alessandro
name: Martinelli, Guido
name: Sanfilippo, Francesco
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: As one approaches the continuum limit, $QCD$ systems, investigated via numerical simulations, remain trapped in sectors of field space with fixed topological charge. As a consequence the numerical studies of physical quantities may give biased results. The same is true in the case of two dimensional $CP^{N-1}$ models. In this paper we show that metadynamics, when used to simulate $CP^{N-1}$, allows to address efficiently this problem. By studying $CP^{20}$ we show that we are able to reconstruct the free energy of the topological charge $F(Q)$ and compute the topological susceptibility as a function of the coupling and of the volume. This is a very important physical quantity in studies of the dynamics of the $θ$ vacuum and of the axion. This method can in principle be extended to $QCD$ applications.
description: Final version accepted on JHEP. Simulations extended and statistics made homogeneous to ease comparison with HMC
Supplementary information for: "A Novel Mutant FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure" by Zariñán et al. Revised version.
Creators: name: Zariñán, Teresa
name: Mayorga, Julio
name: Jardon-Valadez, Eduardo
name: Gutiérrez-Sagal, Rubén
name: Maravillas-Montero, José Luis
name: Mejía-Domínguez, Nancy R
name: Martínez-Luis, Iván
name: Yacini-Torres, Omar G.
name: Cravioto María Del Carmen
name: Reiter, Eric
name: Ulloa-Aguirre, Alfredo
Publisher: name: figshare
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Genetics
subject: FOS: Biological sciences

description: We herein show the revised version of Supplementary material corresponding to the study entitled "Molecular Physiopathogenesis of a Novel Mutant FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure. In Vivo, In Vitro, and In Silico Studies and Comparison with the Trafficking-Defective D408Y FSH Receptor.
Altered Ca 2+ concentration, permeability and buffering in the myofibre Ca 2+ store of a mouse model of malignant hyperthermia: Ca2+management in Y522S cells
Creators: name: Zhou, Jingsong
name: Royer, Leandro
name: Figueroa, Lourdes
name: Pouvreau, Sandrine
name: Lee, Chang Seok
name: Ríos, Eduardo
name: Manno, Carlo
name: Volpe, Pompeo
name: Meissner, Gerhard
name: Nori, Alessandra
name: Hamilton, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Malignant hyperthermia (MH) is linked to mutations in the type 1 ryanodine receptor, RyR1, the Ca2+ channel of the sarcoplasmic reticulum (SR) of skeletal muscle. The Y522S MH mutation was studied for its complex presentation, which includes structurally and functionally altered cell ‘cores’. Imaging cytosolic and intra-SR [Ca2+] in muscle cells of heterozygous YS mice we determined Ca2+ release flux activated by clamp depolarization, permeability (P) of the SR membrane (ratio of flux and [Ca2+] gradient) and SR Ca2+ buffering power (B). In YS cells resting [Ca2+]SR was 45% of the value in normal littermates (WT). P was more than doubled, so that initial flux was normal. Measuring [Ca2+]SR(t) revealed dynamic changes in B(t). The alterations were similar to those caused by cytosolic BAPTA, which promotes release by hampering Ca2+-dependent inactivation (CDI). The [Ca2+] transients showed abnormal ‘breaks’, decaying phases after an initial rise, traced to a collapse in flux and P. Similar breaks occurred in WT myofibres with calsequestrin reduced by siRNA; calsequestrin content, however, was normal in YS muscle. Thus, the Y522S mutation causes greater openness of the RyR1, lowers resting [Ca2+]SR and alters SR Ca2+ buffering in a way that copies the functional instability observed upon reduction of calsequestrin content. The similarities with the effects of BAPTA suggest that the mutation, occurring near the cytosolic vestibule of the channel, reduces CDI as one of its primary effects. The unstable SR buffering, mimicked by silencing of calsequestrin, may help precipitate the loss of Ca2+ control that defines a fulminant MH event.
Dead Reckoning Localization Technique for Mobile Wireless Sensor Networks
Creators: name: Rashid, Haroon
name: Turuk, Ashok Kumar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Localization in wireless sensor networks not only provides a node with its geographical location but also a basic requirement for other applications such as geographical routing. Although a rich literature is available for localization in static WSN, not enough work is done for mobile WSNs, owing to the complexity due to node mobility. Most of the existing techniques for localization in mobile WSNs uses Monte-Carlo localization, which is not only time-consuming but also memory intensive. They, consider either the unknown nodes or anchor nodes to be static. In this paper, we propose a technique called Dead Reckoning Localization for mobile WSNs. In the proposed technique all nodes (unknown nodes as well as anchor nodes) are mobile. Localization in DRLMSN is done at discrete time intervals called checkpoints. Unknown nodes are localized for the first time using three anchor nodes. For their subsequent localizations, only two anchor nodes are used. The proposed technique estimates two possible locations of a node Using Bezouts theorem. A dead reckoning approach is used to select one of the two estimated locations. We have evaluated DRLMSN through simulation using Castalia simulator, and is compared with a similar technique called RSS-MCL proposed by Wang and Zhu .
description: Journal Paper, IET Wireless Sensor Systems, 2015
Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor: Ca2+signalling consequences of defective CaM binding to RyR2
Creators: name: Damon, Brooke James
name: Yamaguchi, Naohiro
name: Cleemann, Lars
name: Zhang, Xiao-Hua
name: Meissner, Gerhard
name: Arnáiz-Cot, Juan José
name: Morad, Martin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Cardiac ryanodine receptor (RyR2) is a homotetramer of 560 kDa polypeptides regulated by calmodulin (CaM), which decreases its open probability at diastolic and systolic Ca2+ concentrations. Point mutations in the CaM-binding domain of RyR2 (W3587A/L3591D/F3603A, RyR2ADA) in mice result in severe cardiac hypertrophy, poor left ventricle contraction and death by postnatal day 16, suggesting that CaM inhibition of RyR2 is required for normal cardiac function. Here, we report on Ca2+ signalling properties of enzymatically isolated, Fluo-4 dialysed whole cell clamped cardiac myocytes from 10–15-day-old wild-type (WT) and homozygous Ryr2ADA/ADA mice. Spontaneously occurring Ca2+ spark frequency, measured at −80 mV, was 14-fold lower in mutant compared to WT myocytes. ICa, though significantly smaller in mutant myocytes, triggered Ca2+ transients that were of comparable size to those of WT myocytes, but with slower activation and decay kinetics. Caffeine-triggered Ca2+ transients were about three times larger in mutant myocytes, generating three- to four-fold bigger Na+-Ca2+ exchanger NCX currents (INCX). Mutant myocytes often exhibited Ca2+ transients of variable size and duration that were accompanied by similarly alternating and slowly activating INCX. The data suggest that RyR2ADA mutation produces significant reduction in ICa density and ICa-triggered Ca2+ release gain, longer but infrequently occurring Ca2+ sparks, larger sarcoplasmic reticulum Ca2+ loads, and spontaneous Ca2+ releases accompanied by activation of large and potentially arrhythmogenic inward INCX.
(106) Jean Campbell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Continued fraction expansions in connection with the metric Mahler measure
Creators: name: Samuels, Charles L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11A51, 11G50, 11R09, 11J70

description: The metric Mahler measure was first studied by Dubickas and Smyth in 2001 as a means of phrasing Lehmer's conjecture in topological language. More recent work of the author examined a parametrized family of generalized metric Mahler measures that gives rise to a series of new, and apparently difficult, problems. We establish a connection between these metric Mahler measures and the theory of continued fractions in a certain class of special cases. Our results enable us to calculate metric Mahler measures in several new examples.
การพัฒนาสื่อมัลติมีเดียในการนำเสนอข้อมูลเชิงประวัติศาสตร์ของแหล่งท่องเที่ยวในเมืองเชียงใหม่
Creators: name: พิมพ์ชนก สุวรรณศรี
name: กัญญนัทธ์ ศิริ
name: ไพรสันต์ สุวรรณศรี
name: ศุภณัฐ มะโนเรือง
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2563
Subjects: สื่อมัลติมีเดีย
แหล่งท่องเที่ยว
ประวัติศาสตร์

description: วารสารมหาวิทยาลัยศิลปากร, 40, 2, 23-33
title: Landammann und Ständerat Josef Hildebrand, Zug
title: Geboren am 28. Juni 1855, Gestorben am 16. März 1935
titleType: Subtitle
Creators: name: Etter, Philipp
Publisher: name: Zentralbibliothek Zürich
Year: 1935
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Hildebrand, Josef

description: [Sonderdruck aus: Zuger Nachr. 18. März 1935]. Die Angabe stammt aus der Print-Aufnahme, nicht überprüft.
Modulation of the autonomic nervous system and behaviour by acute glial cell G q protein-coupled receptor activation in vivo: Glial GPCR signalling in physiology and behaviourin vivo
Creators: name: Boyt, Kristen
name: McCarthy, Ken
name: Agulhon, Cendra
name: Roth, Bryan
name: Friocourt, Francois
name: Xie, Alison Xiaoqiao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Glial fibrillary acidic protein (GFAP)-expressing cells (GFAP+ glial cells) are the predominant cell type in the central and peripheral nervous systems. Our understanding of the role of GFAP+ glial cells and their signalling systems in vivo is limited due to our inability to manipulate these cells and their receptors in a cell type-specific and non-invasive manner. To circumvent this limitation, we developed a transgenic mouse line (GFAP-hM3Dq mice) that expresses an engineered Gq protein-coupled receptor (Gq-GPCR) known as hM3Dq DREADD (designer receptor exclusively activated by designer drug) selectively in GFAP+ glial cells. The hM3Dq receptor is activated solely by a pharmacologically inert, but bioavailable, ligand (clozapine-N-oxide; CNO), while being non-responsive to endogenous GPCR ligands. In GFAP-hM3Dq mice, CNO administration increased heart rate, blood pressure and saliva formation, as well as decreased body temperature, parameters that are controlled by the autonomic nervous system (ANS). Additionally, changes in activity-related behaviour and motor coordination were observed following CNO administration. Genetically blocking inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ increases in astrocytes failed to interfere with CNO-mediated changes in ANS function, locomotor activity or motor coordination. Our findings reveal an unexpectedly broad role of GFAP+ glial cells in modulating complex physiology and behaviour in vivo and suggest that these effects are not dependent on IP3-dependent increases in astrocytic Ca2+.
THE HIPSTER ECONOMY
Creators: name: GEROSA, ALESSANDRO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Creative economy is one of the paradigmatic economic imaginaries of our age, that shapes national policies and economic behaviours. Recently, an ongoing colonisation of labour-intensive sectors by the imaginary of creative economy is observable, resulting in the birth of a new hybrid �hipster economic imaginary�, that combines key features typical of canonical creative occupations with the ones of manual, labour-intensive occupations. This dissertation will be devoted to the analysis of some businesses consistently influenced by such a �Hybrid economic imaginary�. As businesses are shaped and conducted by their owners, our focus will be on the micro-entrepreneurs that manage them. Accordingly, an exploratory empirical research will be performed with the main objective of analysing micro-entrepreneurs in the specific sector of food and beverage retailing. The choice to focus on this sector, and more specifically on �hybrid bars� and gourmet food trucks has been taken both for their relevance in the Italian scenario, their centrality in Milanese urban policies and for their intense recourse to the imaginary. The micro-entrepreneurs owners of these businesses will be analysed in the three dimensions that characterise them as economic actors, that is, their identities, working conditions and practises. The aim is to develop an overall picture of how retailers profession change under the influence of the hybrid imaginary of �hipster economy�, how they interact and exercise their limited agency in relation to it and implicitly thus also to test the opening hypothesis just illustrated. Moreover, as creative economy imaginary is today also powerfully shaping local processes of urban transformation, we will also analyse how �hipster economic imaginaries� can also shape local identities and influence urban development taking one case study from Milan, deeply connected with the development of hybrid bars. In Chapter 1 we will first outline a critical history of the creative economy imaginary and then illustrate the general literature review of the approaches and theoretical frameworks used along the dissertation. In chapter 2 we will concentrate on the professional subjectivity of micro-entrepreneurs as it emerges from the interaction between their individual limited agency and the imaginary. Passing to chapter 3, we will analyse their working conditions using the lens of passionate work. Chapter 4 is devoted to the actual practises of micro-entrepreneurs during their everyday work, through which they deal to the customers an authentic experience. Ultimately, in chapter 5 we will analyse the case study of the so-called �NoLo� neighbourhood. Lastly, in the conclusions we will attempt to summarise the findings to develop a more comprehensive and detailed description of the hipster economy imaginary and of the micro-entrepreneurs that work under it.
(103) Elizabeth Campbell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Ranolazine recruits muscle microvasculature and enhances insulin action in rats: Ranolazine, microvasculature and insulin action
Creators: name: Zhao, Lina
name: Chai, Weidong
name: Liu, Zhenqi
name: Cao, Wenhong
name: Dong, Zhenhua
name: Fu, Zhuo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Ranolazine, an anti-anginal compound, has been shown to significantly improve glycaemic control in large-scale clinical trials, and short-term ranolazine treatment is associated with an improvement in myocardial blood flow. As microvascular perfusion plays critical roles in insulin delivery and action, we aimed to determine if ranolazine could improve muscle microvascular blood flow, thereby increasing muscle insulin delivery and glucose use. Overnight-fasted, anaesthetized Sprague-Dawley rats were used to determine the effects of ranolazine on microvascular recruitment using contrast-enhanced ultrasound, insulin action with euglycaemic hyperinsulinaemic clamp, and muscle insulin uptake using 125I-insulin. Ranolazine's effects on endothelial nitric oxide synthase (eNOS) phosphorylation, cAMP generation and endothelial insulin uptake were determined in cultured endothelial cells. Ranolazine-induced myographical changes in tension were determined in isolated distal saphenous artery. Ranolazine at therapeutically effective dose significantly recruited muscle microvasculature by increasing muscle microvascular blood volume (∼2-fold, P < 0.05) and increased insulin-mediated whole body glucose disposal (∼30%, P= 0.02). These were associated with an increased insulin delivery into the muscle (P < 0.04). In cultured endothelial cells, ranolazine increased eNOS phosphorylation and cAMP production without affecting endothelial insulin uptake. In ex vivo studies, ranolazine exerted a potent vasodilatatory effect on phenylephrine pre-constricted arterial rings, which was partially abolished by endothelium denudement. In conclusion, ranolazine treatment vasodilatates pre-capillary arterioles and increases microvascular perfusion, which are partially mediated by endothelium, leading to expanded microvascular endothelial surface area available for nutrient and hormone exchanges and resulting in increased muscle delivery and action of insulin. Whether these actions contribute to improved glycaemic control in patients with insulin resistance warrants further investigation.
(104) Thomas Campbell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101) Alexander Forbes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
I 'REATI DI DURATA'
Creators: name: AIMI, ALBERTO
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: This PhD thesis deals with the many legal questions concerning the juridical treatment of crimes which last in time. The author tries to explain the phenomenon of "a crime-timespan" as a multiple infringement of the same law and therefore a concurrence of offences. This multiple infringement of the same precept can nevertheless be seen as one crime thanks to the application of the rules and principles quintessential to the treatment of the concurrence of offences in criminal law. Consisting of the same phenomenon, the 3 different types of crimes (reato permanente, abituale, a consumazione prolungata) that can last in time should overall be reduced to just one type: the reato permanente. That solves most of the legal questions concerning the "crime-timespan" phenomenon, since the Italian penal code provides a clear set of rules just for the reato permanente.
Instances of the Kaplansky-Lvov multilinear conjecture for polynomials of degree three
Creators: name: Dykema, Kenneth J.
name: Klep, Igor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 16R99, 16R30 (Primary), 16S50, 15A21 (Secondary)

description: Given a positive integer d, the Kaplansky-Lvov conjecture states that the set of values of a multilinear noncommutative polynomial f on the matrix algebra M_d(C) is a vector subspace. In this article the technique of using one-wiggle families of Sylvester's clock-and-shift matrices is championed to establish the conjecture for polynomials f of degree three when d is even or d<17.
description: v3: 17 pages (minor changes); supplementary material (a Mathematica notebook) is available from Other formats or can be found at http://www.math.auckland.ac.nz/~igorklep/publ.html
A CELL REPROGRAMMING-BASED APPROACH TO STUDY 7Q11.23 GENE DOSAGE IMBALANCES IN WILLIAMS BEUREN SYNDROME AND AUTISM SPECTRUM DISORDER
Creators: name: ATASHPAZGARGARI, SINA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Symmetrical gene dosage imbalances at 7q11.23 chromosomal region cause two unique neurodevelopmental diseases, Williams Beuren Syndrome (WBS) and the 7q11.23 microduplication associated to autistic spectrum disorder (7dup-ASD). Although both these diseases share common features such as intellectual disability and craniofacial dysmorphism, they can be distinguished by distinct social and language abilities: WBS patients characterized by hypersociality and comparatively well-preserved language skills while 7dup-ASD is associated with impairment in social interaction and communicative skills. The involvement of same genetic interval in these disease, points out to small subset of dosage-sensitive genes affecting cognition, social behavior and communication skills. Among the genes in the deleted region, some were shown to contribute to the abnormalities in these patients through transgenic mice models and individual case reports. However, the precise cellular and molecular phenotypes associated with these syndromes in disease-relevant cell-types are unknown due to the scarce availability of primary diseased tissues. Transcription factor induced somatic cell reprogramming has bypassed such fundamental limitation and has enabled us to model human diseases, elucidate their pathogenesis and discover new therapeutics by screening small chemicals/drugs on these models. During my PhD studies, I focused on the functional dissection of these complementary diseases at the level of transcriptional deregulation in patient-derived iPSC and its differentiated derivatives such as neural crest stem cells, mesenchymal stem cells, and neural progenitors. To this end, we have assembled a unique cohort of typical WBS, atypical WBS (patient with a partial deletion) and 7dup-ASD patients (along with unaffected relatives), and then I used mRNA reprogramming to establish and characterize at least 3 independent iPSC lines from a total of 12 individuals. High throughput mRNA sequencing on iPSC revealed critical transcriptional derangements in disease-relevant pathways already at the pluripotent state. These alterations found to be selectively amplified upon differentiation into disease-relevant lineages, thereby establishing the value of large iPSC cohorts in the elucidation of disease-relevant developmental pathways. Finally, we created an open-access web-based platform to make accessible our multi-layered datasets and integrate contributions by the entire community working on the molecular dissection of the 7q11.23 syndromes.
Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses: Adiponectin improves microvascular insulin resistance
Creators: name: Fu, Zhuo
name: Wu, Jing
name: Zhao, Lina
name: Barrett, Eugene
name: Cao, Wenhong
name: Liu, Zhenqi
name: Aylor, Kevin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Hypoadiponectinaemia is closely associated with endothelial dysfunction and insulin resistance, and microvasculature plays a critical role in the regulation of insulin action in muscle. Here we tested whether adiponectin replenishment could improve metabolic insulin sensitivity in male rats fed a high-fat diet (HFD) via the modulation of microvascular insulin responses. Male Sprague–Dawley rats were fed either a HFD or low-fat diet (LFD) for 4 weeks. Small resistance artery myograph changes in tension, muscle microvascular recruitment and metabolic response to insulin were determined. Compared with rats fed a LFD, HFD feeding abolished the vasodilatory actions of globular adiponectin (gAd) and insulin on pre-constricted distal saphenous arteries. Pretreatment with gAd improved insulin responses in arterioles isolated from HFD rats, which was blocked by AMP-activated protein kinase (AMPK) inhibition. Similarly, HFD abolished microvascular responses to either gAd or insulin and decreased insulin-stimulated glucose disposal by ∼60%. However, supplementing gAd fully rescued insulin’s microvascular action and significantly improved the metabolic responses to insulin in HFD male rats and these actions were abolished by inhibition of either AMPK or nitric oxide production. We conclude that HFD induces vascular adiponectin and insulin resistance but gAd administration can restore vascular insulin responses and improve insulin’s metabolic action via an AMPK- and nitric oxide-dependent mechanism in male rats.
Assessment of Improvement Areas for Increasing the Capacity of Ethio-Djibouti Railway Line
Creators: name: YOHANNES MELKAMU
Publisher: name: Zenodo
Year: 2018

description: Ethio-Djibouti railway line can support the economic growth of the country by allowing transportation of more goods than now, reduce greenhouse gas emission (environmental friendly), reduce road congestion, allows the country to increase the variety of export goods. This research aims to analyze the capacity issues of Ethio-Djibouti railway line and identify and assess possible capacity improvement areas to satisfy the railway transport demand of Ethiopia for the coming 50years time period.