cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-scenario Satellite Drought Assessment using Moisture Stress Index (MSI) in Mae Suk Watershed, Mae Chai District, Phayao Province
Creators: name: Siriwan Ruenrom
Publisher: name: School of Information and Communication Technology, University of Phayao
Year: 2024
Subjects: Remote sensing
Land use
Moisture Stress Index
Phayao
Upper Ing watershed

description: The Journal of Spatial Innovation Development, 5, 3, 93-105
Use of Sentinel-2 Image Data for Terrestrial Boundary Calculation of Thailand
Creators: name: Jutamad Srikongruk
Publisher: name: School of Information and Communication Technology, University of Phayao
Year: 2024
Subjects: The terrestrial boundaries of Thailand
Remote Sensing
Sentinel-2 Image
Visual interpretation

description: The Journal of Spatial Innovation Development, 5, 3, 106-119
Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony
Creators: name: Kumari, Vandana
name: Prasad, Kona Madhavinadha
name: Kalia, Inderjeet
name: Sindhu, Gagandeep
name: Dixit, Rajnikant
name: Rawat, Diwan S.
name: Singh, O. P.
name: Singh, Agam P.
name: Pandey, Kailash C.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The family of apicomplexan specific proteins contains caspases–like proteins called “metacaspases”. These enzymes are present in the malaria parasite but absent in human; therefore, these can be explored as potential drug targets. We deleted the MCA-2 gene from Plasmodium berghei genome using a gene knockout strategy to decipher its precise function. This study has identified that MCA-2 plays an important role in parasite transmission since it is critical for the formation of gametocytes and for maintaining an appropriate number of infectious sporozoites required for sporogony. It is noticeable that a significant reduction in gametocyte, oocysts, ookinete and sporozoites load along with a delay in hepatocytes invasion were observed in the MCA-2 knockout parasite. Furthermore, a study found the two MCA-2 inhibitory molecules known as C-532 and C-533, which remarkably inhibited the MCA-2 activity, abolished the in vitro parasite growth, and also impaired the transmission cycle of P. falciparum and P. berghei in An. stephensi. Our findings indicate that the deletion of MCA-2 hampers the Plasmodium development during erythrocytic and exo-erythrocytic stages, and its inhibition by C-532 and C-533 critically affects the malaria transmission biology.
Betweenness Centrality Based Dynamic Source Routing for Flying Ad Hoc Networks in Marching Formation
Creators: name: Yang, Shaoshi
name: Zhao, Wei
name: Wang, Chu-Meng
name: Dong, Wen-Yu
name: Ju, Xiaojie
Publisher: name: arXiv
Year: 2025
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Designing high-performance routing protocols for flying ad hoc networks (FANETs) is challenging due to the diversity of applications and the dynamics of network topology. The existing general-purpose routing protocols for ad hoc networks often oversimplify mobility patterns and disregard the unequal importance of nodes, resulting in suboptimal routing decisions that are unsuitable for task-oriented FANETs. To break the bottleneck, in this paper we propose a betweenness centrality based dynamic source routing (BC-DSR) protocol for a flying ad hoc network (FANET) in marching formation. Firstly, we introduce a Gauss-Markov group (GMG) mobility model based on the leader-follower pattern, which accurately captures the temporal and spatial correlations of node movements in the realistic marching formation. Besides, we exploit the concept of BC defined in graph theory to measure the structural unequal importance of relay nodes, i.e., to determine link weights, in the particular marching formation topology. The path of least cost is calculated relying on a weighted directed graph constructed. The ns-3 based simulation results demonstrate that our BCDSR protocol achieves higher packet-delivery ratio and lower average end-to-end latency and routing overhead ratio than representative benchmark protocols used in FANETs, while maintaining a reasonably small network jitter.
description: 8 pages, 13 figures, 1 table, accepted to appear on IEEE Transactions on Vehicular Technology, Mar, 2025
INVESTIGATION OF STRATEGIES TO BUILD POSITIVE TEACHER-STUDENT RELATIONSHIPS WITH STUDENTS WITH EMOTIONAL DISTURBANCE: SPECIAL EDUCATION TEACHERS’ OPINIONS
Creators: name: Gettys, Jessica Nicole
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Special education and disability

description: Forming positive teacher-student relationships with students has been identified as a protective factor for students. However, many teachers struggle to form and maintain a positive relationship with students diagnosed with an emotional disturbance. It is essential that teachers have tools to help build and maintain positive teacher-student relationships.This study focused on investigating licensed special education teachers that have taught seventh through twelve grade students with emotional disturbances. Out of the nine individuals who were sent the survey, all nine participants completed it. The survey was conducted to identify common negative behaviors and to identify what strategies teachers would like more information about to help them form positive teacher-student relationships. The survey consisting of short answer questions, multiple choice questions, yes or no questions, and questions that ask them to explain their answers.The findings from the literature review and the survey data supported a need for a handbook to be created in order to inform special education teachers of ways to develop and maintain positive teacher-student relationships with students diagnosed with an emotional disturbance. Strategies are included in the handbook for teachers to reduce negative behaviors with students diagnosed with an emotional disturbance.
Optical Techniques for Analysis of Pharmaceutical Formulations
Creators: name: Griffin, Scott R
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Analytical chemistry not elsewhere classified

description: The symmetry requirements of both second harmonic generation (SHG) and triboluminescence (TL) provide outstanding selectivity to noncentrosymmetric crystals, leading to high signal to noise measurements of crystal growth and nucleation of active pharmaceutical ingredients (API) within amorphous solid dispersions (ASD) during accelerated stability testing. ASD formulations are becoming increasingly popular in the pharmaceutical industry due to their ability to address challenges associated with APIs that suffer from poor dissolution kinetics and low bioavailability as a result of low aqueous solubility. ASDs kinetically trap APIs into an amorphous state by dispersing the API molecules within a polymer matrix. The amorphous state of the API leads to an increase in apparent solubility, faster dissolution kinetics, and an increase in bioavailability. Both SHG and TL are used to quantitatively and qualitatively detect the crystal growth and nucleation within ASD formulations at the parts per million (ppm) regime. TL is the emission of light upon mechanical disruption of a piezoelectrically active crystal. Instrumentation was developed to rapidly determine the qualitative presence of crystals within nominally amorphous pharmaceutical materials in both powders and slurries. SHG was coupled with a controlled environment for in situ stability testing (CEiST) to enable in situ accelerated stability testing of ASDs. Single particle tracking enabled by the CEiST measurements provided insights into crystal growth rate distributions present due to local differences within the material. Accelerated stability testing monitored by in situ measurements increased the signal to noise in recovered nucleation and crystal growth rates by suppressing the Poisson noise normally present within conventional accelerated stability tests. The disparities between crystal growth and nucleation kinetics on the surface versus within bulk material were also investigated by single particle tracking and in situ measurements. Crystals were found to grow faster in the bulk compared to single crystals growing on the surface while total crystallinity was found to be higher on the surface due to radial growth habits of crystals on the surface compared to columnar growth within the bulk. To increase the throughput of the in situ measurements, a temperature and relative humidity array (TRHA) was developed. The TRHA utilizes a temperature gradient and many individual liquid wells to enable the use of a multitude of different conditions at the same time which can reduce time required to inform formulations design of stability information.
Dissecting the role of Plasmodium Metacaspase-2 in malaria gametogenesis and sporogony
Creators: name: Kumari, Vandana
name: Prasad, Kona Madhavinadha
name: Kalia, Inderjeet
name: Sindhu, Gagandeep
name: Dixit, Rajnikant
name: Rawat, Diwan S
name: Singh, O. P
name: Singh, Agam P
name: Pandey, Kailash C
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The family of apicomplexan specific proteins contains caspases–like proteins called "metacaspases". These enzymes are present in the malaria parasite but absent in human; therefore, these can be explored as potential drug targets. We deleted the MCA-2 gene from Plasmodium berghei genome using a gene knockout strategy to decipher its precise function. This study has identified that MCA-2 plays an important role in parasite transmission since it is critical for the formation of gametocytes and for maintaining an appropriate number of infectious sporozoites required for sporogony. It is noticeable that a significant reduction in gametocyte, oocysts, ookinete and sporozoites load along with a delay in hepatocytes invasion were observed in the MCA-2 knockout parasite. Furthermore, a study found the two MCA-2 inhibitory molecules known as C-532 and C-533, which remarkably inhibited the MCA-2 activity, abolished the in vitro parasite growth, and also impaired the transmission cycle of P. falciparum and P. berghei in An. stephensi. Our findings indicate that the deletion of MCA-2 hampers the Plasmodium development during erythrocytic and exo-erythrocytic stages, and its inhibition by C-532 and C-533 critically affects the malaria transmission biology.
Additional file 1 of The REPAIR study: oral antibiotics to prevent infection and wound dehiscence after obstetric perineal tear—a double-blinded placebo controlled randomized trial
Creators: name: Perslev, Kathrine
name: Klarskov, Niels
name: Bergholt, Thomas
name: Jangö, Hanna
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. SPIRIT Checklist.
sj-pdf-2-smm-10.1177_09622802211032712 - Supplemental material for Distance-based Classification and Regression Trees for the analysis of complex predictors in health and medical research
Creators: name: Johns, Hannah
name: Bernhardt, Julie
name: Churilov, Leonid
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-2-smm-10.1177_09622802211032712 for Distance-based Classification and Regression Trees for the analysis of complex predictors in health and medical research by Hannah Johns, Julie Bernhardt and Leonid Churilov in Statistical Methods in Medical Research
Clinical features of the first critical case of acute encephalitis caused by avian influenza A (H5N6) virus
Creators: name: Zhang, Libing
name: Liu, Kaituo
name: Su, Qin
name: Chen, Xiao
name: Wang, Xiaoquan
name: Li, Qingfeng
name: Wang, Wenlei
name: Mao, Xuhua
name: Xu, Jinmei
name: Zhou, Xin
name: Xu, Qin
name: Zhou, Le
name: Liu, Xiufan
name: Zhang, Pinghu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Highly pathogenic avian influenza virus (HPAIV) such as H5N1, H5N6, and H7N9 have been reported to frequently infect human, but acute encephalitis caused by HPAIV in human have been rarely reported. We report the first critical case of acute encephalitis with mild pneumonia caused by H5N6 virus. On January 25 of 2022, a 6-year-old girl with severe neurological symptoms was admitted to our hospital and rapidly developed to seizures and coma. Brain imaging showed abnormalities. Electroencephalogram (EEG) presented abnormal slow waves. Cerebrospinal fluid (CSF) contained elevated protein (1.64 g/L) and white cells (546×106/L). Laboratory investigations revealed abnormally elevated transaminases, lactate dehydrogenase and cytokines in serum. A novel reassortant H5N6 virus was identified from the patient’s serum, CSF and tracheal aspirate specimens. Phylogenic analysis indicated that this virus was a novel reassortant avian-origin influenza A (H5N6) virus belonged into clade 2.3.4.4b. This patient was diagnosed with acute encephalitis and discharged from the hospital accompanied with language barrier. Epidemiological investigation confirmed that wild waterfowls were the direct source of infection of this case. Our study highlights the urgent need to pay attenuation to acute encephalitis caused by HPAIV.
Additional file 2 of The REPAIR study: oral antibiotics to prevent infection and wound dehiscence after obstetric perineal tear—a double-blinded placebo controlled randomized trial
Creators: name: Perslev, Kathrine
name: Klarskov, Niels
name: Bergholt, Thomas
name: Jangö, Hanna
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Ethical approval document.
Large Datasets in R - Plant Phenology & Temperature Data from NEON
Creators: name: Jones, Megan
name: Stanish, Lee
name: Robinson, Natalie
name: Jones, Katherine
name: Flagg, Cody
Publisher: name: QUBES
Year: 2018

description: This module series covers how to import, manipulate, format and plot time series data stored in .csv format in R. Originally designed to teach researchers to use NEON plant phenology and air temperature data; has been used in undergraduate classrooms.
Effects of Movement on Biometric Facial Recognition in Body-Worn Cameras
Creators: name: Bryan, Julia
Publisher: name: Purdue University Graduate School
Year: 2020

description: This study examined how three different manipulations of a single policing stance affected the quality scores and matching performance in a biometric facial recognition system; it was conducted in three phases. In the first phase, the researcher collected qualitative survey data from active, sworn law enforcement officers in 15 states. In the second phase, the researcher collected quantitative data using a single facial recognition subject and a static body-worn camera mounted to an adjustable tripod. In the third phase, the researcher collected quantitative data from body-worn camera-equipped law enforcement officers who filmed a stationary target as they executed a series of specified movements from the interview stance. The second phase tested two different body-worn cameras: one that is popular among law enforcement agencies in the United States, the Axon Body 2; and one that is inexpensive and available to the general public via a popular internet commerce website. The third phase tested only the Axon Body 2. Results of the study showed that matching results are poor in a biometric system where the test body-worn camera was the sensor, with error rates as high as 100% when the body-worn camera wearer was in motion. The general conclusion of this study is that a body-worn camera is not a suitable sensor for a biometric facial recognition system at this time, though advances in camera technology and biometric systems may close the gap in the future.
Total RNA sequencing of Phlebotomus chinensis, a neglected vector in China, simultaneously revealed viral, bacterial, and eukaryotic microbes that are potentially pathogenic to humans
Creators: name: Wang, Jing
name: Gou, Qin-yu
name: Luo, Geng-yan
name: Hou, Xin
name: Liang, Guodong
name: Shi, Mang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Phlebotomus chinensis sandfly is a neglected insect vector in China which is well-known for carrying Leishmania. Recent studies have expanded its pathogen repertoire with two novel arthropod-borne phleboviruses capable of infecting human and animals. Despite these discoveries, our knowledge on the general pathogen diversity and overall microbiome composition of this vector species are still very limited. Here we carried out a meta-transcriptomics analysis which simultaneously revealed the actively replicating/transcribing RNA viruses, DNA viruses, bacteria and eukaryotic microbes, namely, “total microbiome”, of several sandfly populations in China. Strikingly, “microbiome” made up 1.8% of total non-ribosomal RNA and were comprised of more than 87 species, among which 70 were novel, including divergent members of the genera Flavivirus and of the family Trypanosomatidae. Importantly, among these microbes we were able to reveal four distinguished types of human and/or mammalian pathogens, including two phleboviruses (hedi and wuxiang viruses), one novel Spotted fever group rickettsia, as well as a member of Leishmania donovani complex, among which hedi virus and Leishmania each had > 50% pool prevalence rate and relatively high abundance levels. Our study also showed the ubiquitous presence of an endosymbiont, namely Wolbachia, although no anti-viral or anti-pathogen effect were detected based on our data. In summary, our results uncovered the much un-explored diversity of microbes harbored by sandflies in China and demonstrated that high pathogen diversity and abundance is currently present in multiple populations, implying disease potential for exposed local human population or domestic animals.
Observational Comparison Between Confined and Eruptive Flares: Magnetohydrodynamics Instability Parameters in a Similar Magnetic Configuration
Creators: name: Teraoka, Kouhei
name: Yamasaki, Daiki
name: Kawabata, Yusuke
name: Imada, Shinsuke
name: Shimizu, Toshifumi
Publisher: name: arXiv
Year: 2025
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Unstable states of the solar coronal magnetic field structure result in various flare behaviors. In this study, we compared the confined and eruptive flares that occurred under similar magnetic circumstances in the active region 12673, on 2017 September 6, using the twist number, decay index, and height of magnetic field lines to identify observational behaviors of the flare eruption. We investigated the parameters from the magnetic field lines involved in an initial energy release, which were identified from the positions of the core of flare ribbons, i.e., flare kernels. The magnetic field lines were derived by nonlinear force-free field modeling calculated from the photospheric vector magnetic field obtained by the Solar Dynamics Observatory SDO/Helioseismic and Magnetic Imager, and flare kernels were identified from the 1600 angstrom data obtained by the SDO/Atmospheric Imaging Assembly. The twist number of all the magnetic field lines in the confined flare was below 0.6; however, the twist number in seven out of twenty-four magnetic field lines in the eruptive flare was greater than 0.6. These lines were tall. It is found that the decay index is not a clear discriminator of the confined and eruptive flares. Our study suggests that some magnetic field lines in the kink instability state may be important for eruptive flares, and that taller magnetic field lines may promote flare eruption.
description: Accepted for the publication in ApJ, 24 pages, 5 figures
Political Participation Among Latinos: Why It Matters and How to Increase It
Creators: name: Suthers, Cassey H
Publisher: name: Purdue University Graduate School
Year: 2020

description: This study sought to identify obstacles and challenges that impact political participation and involvement among Latino voters. At the same time, it explored how the Latino Democrats of Allen County (LDAC), a constituency caucus in a primarily conservative area, could address such barriers to engage Latinos from the area politically (specifically in support of the Democratic party). Social Identity Theory provided a backdrop from which to examine the challenges and obstacles that Latinos face to participating in local government. By exploring these questions from the perspective of Social Identity Theory, I examined how a demographic in a primarily conservative area grapples with their political participation. Findings suggest that Latinos struggle with their participation due to lack of awareness about opportunity, low political efficacy, lack of trust in the political process and those that facilitate it, and lack of education about how the political process works. Literature on communication strategies and techniques used by organizations and groups with similar structures and goals provided a roadmap for constructing a functional and meaningful strategic communication plan for LDAC based on the findings from this study.
sj-pdf-1-erp-10.1177_08902070211031762 - Supplemental material for Perceived Characteristics of Life Events—Short-Term Changes in Prosociality and Empathy?
Creators: name: Fassbender, Ina
name: Haehner, Peter
name: Buecker, Susanne
name: Luhmann, Maike
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-erp-10.1177_08902070211031762 for Perceived Characteristics of Life Events—Short-Term Changes in Prosociality and Empathy? by Ina Fassbender, Peter Haehner, Susanne Buecker and Maike Luhmann in European Journal of Personality
sj-pdf-1-prs-10.1177_20414196211035789 – Supplemental material for Evaluation of superior layer configuration of titanium Ti-6Al-4V and aluminium 2024-T3 against soft projectiles
Creators: name: Senthil, K.
name: Sharma, Rachit
name: Rupali, S.
name: Thakur, Ankush
name: Iqbal, M. A.
name: Gupta, N. K.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-1-prs-10.1177_20414196211035789 for Evaluation of superior layer configuration of titanium Ti-6Al-4V and aluminium 2024-T3 against soft projectiles by K. Senthil, Rachit Sharma, S. Rupali, Ankush Thakur, M. A. Iqbal and N. K. Gupta in International Journal of Protective Structures
PRIOT: Pruning-Based Integer-Only Transfer Learning for Embedded Systems
Creators: name: Anada, Honoka
name: Ryu, Sefutsu
name: Usui, Masayuki
name: Kaneko, Tatsuya
name: Takamaeda-Yamazaki, Shinya
Publisher: name: arXiv
Year: 2025
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: On-device transfer learning is crucial for adapting a common backbone model to the unique environment of each edge device. Tiny microcontrollers, such as the Raspberry Pi Pico, are key targets for on-device learning but often lack floating-point units, necessitating integer-only training. Dynamic computation of quantization scale factors, which is adopted in former studies, incurs high computational costs. Therefore, this study focuses on integer-only training with static scale factors, which is challenging with existing training methods. We propose a new training method named PRIOT, which optimizes the network by pruning selected edges rather than updating weights, allowing effective training with static scale factors. The pruning pattern is determined by the edge-popup algorithm, which trains a parameter named score assigned to each edge instead of the original parameters and prunes the edges with low scores before inference. Additionally, we introduce a memory-efficient variant, PRIOT-S, which only assigns scores to a small fraction of edges. We implement PRIOT and PRIOT-S on the Raspberry Pi Pico and evaluate their accuracy and computational costs using a tiny CNN model on the rotated MNIST dataset and the VGG11 model on the rotated CIFAR-10 dataset. Our results demonstrate that PRIOT improves accuracy by 8.08 to 33.75 percentage points over existing methods, while PRIOT-S reduces memory footprint with minimal accuracy loss.
description: Accepted for publication in IEEE Embedded Systems Letters
Additional file 3 of The REPAIR study: oral antibiotics to prevent infection and wound dehiscence after obstetric perineal tear—a double-blinded placebo controlled randomized trial
Creators: name: Perslev, Kathrine
name: Klarskov, Niels
name: Bergholt, Thomas
name: Jangö, Hanna
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Copy of the original funding documentation.
sj-pdf-1-tec-10.1177_02711214211032720 – Supplemental material for A Systematic Review and Meta-Analysis of the Relation Between Engagement and Achievement in Early Childhood Research
Creators: name: Lindström, Esther R.
name: Chow, Jason C.
name: Zimmerman, Kathleen N.
name: Zhao, Hongyang
name: Settanni, Elise
name: Ellison, Alyson
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-pdf-1-tec-10.1177_02711214211032720 for A Systematic Review and Meta-Analysis of the Relation Between Engagement and Achievement in Early Childhood Research by Esther R. Lindström, Jason C. Chow, Kathleen N. Zimmerman, Hongyang Zhao, Elise Settanni and Alyson Ellison in Topics in Early Childhood Special Education
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRV
Creators: name: Wang, Qian
name: Song, Ziyang
name: Yang, Jinghuan
name: He, Qian
name: Mao, Qunying
name: Bai, Yu
name: Liu, Jianyang
name: An, Chaoqiang
name: Yan, Xujia
name: Cui, Bopei
name: Song, Lifang
name: Liu, Dong
name: Xu, Miao
name: Liang, Zhenglun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Analysis of large-scale gene expression post vaccination can provide an overview of immune responses. We used transcriptional approaches to comprehensively analyze the innate immune response signatures elicited by protein subunit (PS) vaccine ZF2001 and an mRNA vaccine named RRV. A fine-grained time-dependent dissection of large-scale gene expression post immunization revealed that ZF001 induced MHC class II-related genes, including cd74 and H2-Aa, more expeditiously than the RRV. Notably, the RRV induced MHC class I-related genes such as Tap1/2, B2m, and H2-D1/K1. At day 21 post immunization, the titres of binding and neutralization antibody (NAb) induced by both vaccines were comparable, which were accordant with the expression level of genes essential to BCR/TCR signalling transduction and B/T cells activation at day 7. However, compared to ZF2001, the early responses of RRV were more robust, including the activation of pattern recognition receptors (PRRs), expression of genes involved in RNA degradation, and transcription inhibition, which are directly related to anti-viral signals. This pattern also coincided with the induction of cytokines by the RRV. Generally, the transcriptomic patterns of two very different vaccines mapped here provide a framework for establishing correlates between the induction of genes and protection, which can be tailored for evoking specific and potent immune responses against SARS-CoV-2.
JASPAR: an open-access database of transcription factor binding profiles
Creators: name: Khan, Aziz
name: Fornes, Oriol
name: Stigliani, Arnaud
name: Gheorghe, Marius
name: Castro-Mondragon, Jaime A.
name: Lee, Robin Van Der
name: Bessy, Adrien
name: Chèneby, Jeanne
name: Shubhada R. Kulkarni
name: Tan, Ge
name: Baranasic, Damir
name: Arenillas, David J.
name: Sandelin, Albin
name: Vandepoele, Klaas
name: Lenhard, Boris
name: Ballester, Benoît
name: Wyeth W. Wasserman
name: Parcy, François
name: Mathelier, Anthony
Publisher: name: F1000 Research Limited
Year: 2018

description: JASPAR is an open-access database of manually curated, non-redundant transcription factor (TF) binding profiles stored as position frequency matrices (PFM) and transcription factor flexible models (TFFM) for TFs from species in six taxonomic groups. The JASPAR CORE collection now includes 1,404 non-redundant PFMs (579 for vertebrates, 489 for plants, 176 for fungi, 133 for insects, 26 for nematodes, and 1 for urochordata). Further, it contains 446 TFFMs (225 for vertebrates, 218 for plants and 3 for insects). All the data can be browsed using an interactive web-interface, and retrieved programmatically using a REST API and through R/Bioconductor package.
Ricci Curvature of Finsler Metrics by Warped Product
Creators: name: Marcal, Patricia
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Algebraic and differential geometry

description: In the present work, we consider a class of Finsler metrics using the warped product notion introduced by B. Chen, Z. Shen and L. Zhao (2018), with another “warping”, one that is consistent with the form of metrics modeling static spacetimes and simplified by spherical symmetry over spatial coordinates, which emerged from the Schwarzschild metric in isotropic coordinates. We will give the PDE characterization for the proposed metrics to be Ricci-flat and construct explicit examples. Whenever possible, we describe both positive-definite solutions and solutions with Lorentz signature. For the latter, the 4-dimensional metrics may also be studied as Finsler spacetimes.
Dynamics of atom-field interaction inside a nonlinear Kerr-like medium filled optical cavity
Creators: name: Kumar, Naveen
name: Chatterjee, Arpita
Publisher: name: arXiv
Year: 2025
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we investigate the dynamics of two two-level atoms interacting with a two-mode field inside an optical cavity, in presence of a nonlinear Kerr-like medium as well as the Stark shift. We derive the exact analytical solution of the time-dependent Schrödinger equation that provides a comprehensive framework for analyzing the system's quantum properties. To characterize the nonclassical features of the radiation field, we examine photon number distribution, second-order correlation function $g^2(0)$, squeezing properties, and Mandel's $Q_M$ parameter. These properties reveal significant insights into the quantum statistical behaviour of the field and its deviation from classicality under different interaction regimes. In addition, we quantify the atom-atom entanglement using linear entropy which captures the mixedness of the atomic subsystem and elucidates the interplay between atom-atom interactions. The results highlight the crucial role of nonlinear interactions and the Stark shift in shaping the quantum correlations and nonclassical phenomena of the system.
description: 22 pages, 6 figures, Accepted in J. Mod. Opt
Additional file 1 of Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study
Creators: name: Camilli, Massimiliano
name: Viscovo, Marcello
name: Felici, Tamara
name: Maggio, Luca
name: Ballacci, Federico
name: Carella, Giacomo
name: Bonanni, Alice
name: Lamendola, Priscilla
name: Tinti, Lorenzo
name: Di Renzo, Antonio
name: Coarelli, Giulia
name: Galli, Eugenio
name: Liuzzo, Giovanna
name: Burzotta, Francesco
name: Montone, Rocco Antonio
name: Sorà, Federica
name: Sica, Simona
name: Hohaus, Stefan
name: Lanza, Gaetano Antonio
name: Crea, Filippo
name: Lombardo, Antonella
name: Minotti, Giorgio
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1
Simulation of Quantum Entanglement and Quantum Teleportation for Advanced Networks
Creators: name: Dermal, Sahana
name: Balasubramanyam, Asvija
name: Raghava, Gudapati Naresh
Publisher: name: arXiv
Year: 2025
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper introduces the indigenous Quantum Network Simulator developed to simulate various quantum network protocols on classical machines. The paper specifically focuses on the simulation of entanglement generation between two quantum memories using the Barrett-Kok protocol, as well as the teleportation of a single qubit utilizing the produced entangled states. Additionally, the impact of error manipulation and other factors on the fidelity of the teleported states is analyzed, revealing strategies for enhancing teleported state fidelity. The existing few quantum network simulators, allow the simulation of teleportation protocol, but they do not account for the experimental aspects of entanglement generation and distribution, which are crucial for achieving any practical implementation. This work aims to bridge this gap and provide a realistic fidelity of the teleported states.
description: 5 pages, 5 figures
Transcriptomic analysis of the innate immune signatures of SARS-CoV-2 protein subunit vaccine ZF2001 and a mRNA vaccine RRV
Creators: name: Wang, Qian
name: Song, Ziyang
name: Yang, Jinghuan
name: He, Qian
name: Mao, Qunying
name: Bai, Yu
name: Liu, Jianyang
name: An, Chaoqiang
name: Yan, Xujia
name: Cui, Bopei
name: Song, Lifang
name: Liu, Dong
name: Xu, Miao
name: Liang, Zhenglun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Analysis of large-scale gene expression post vaccination can provide an overview of immune responses. We used transcriptional approaches to comprehensively analyze the innate immune response signatures elicited by protein subunit (PS) vaccine ZF2001 and a mRNA vaccine named RRV. A fine-grained time-dependent dissection of large-scale gene expression post immunization revealed that ZF001 induced MHC class II-related genes, including cd74 and H2-Aa, more expeditiously than RRV. Notably, RRV induced MHC class I-related genes like Tap1/2, B2m and H2-D1/K1. At day 21 post immunization, the titers of binding and neutralization antibody (NAb) induced by both vaccines were comparable, which were accordant with the expression level of genes essential to BCR/TCR signaling transduction and B/T cells activation at day 7. However, compared to ZF2001, the early responses of RRV were more robust, including activation of pattern recognition receptors (PRRs), expression of genes involved in RNA degradation and transcription inhibition, which are directly related to anti-viral signal. This pattern also coincided with the induction of cytokines by RRV. Generally, the transcriptomic patterns of two very different vaccines mapped here provide a framework for establishing correlates between induction of genes and protection, which can be tailored for evoking specific and potent immune responses against SARS-CoV-2.
Delayed feedback control of self-mobile cavity solitons in a wide-aperture laser with a saturable absorber
Creators: name: Schemmelmann, Tobias
name: Tabbert, Felix
name: Pimenov, Alexander
name: Vladimirov, Andrei G.
name: Gurevich, Svetlana V.
Publisher: name: Weierstrass Institute
Year: 2017
Subjects: subject: wide-aperture laser
subject: saturable absorber
subject: cavity solitons
subject: mode-locking
subject: delayed feedback
subject: 05.45.-a
subject: 42.55.Px
subject: 42.60.Fc
subject: 42.65.Pc
subject: 42.65.Tg

description: We investigate the spatiotemporal dynamics of cavity solitons in a broad area vertical-cavity surface-emitting laser with saturable absorption subjected to time-delayed optical feedback. Using a combination of analytical, numerical and path continuation methods we analyze the bifurcation structure of stationary and moving cavity solitons and identify two different types of traveling localized solutions, corresponding to slow and fast motion. We show that the delay impacts both stationary and moving solutions either causing drifting and wiggling dynamics of initially stationary cavity solitons or leading to stabilization of intrinsically moving solutions. Finally, we demonstrate that the fast cavity solitons can be associated with a lateral mode-locking regime in a broad-area laser with a single longitudinal mode.
Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Creators: name: Seo, Ji-Min
name: Kang, Bobin
name: Song, Rina
name: Noh, Hanmi
name: Kim, Cheolmin
name: Kim, Jong-In
name: Kim, Minsoo
name: Ryu, Dong-Kyun
name: Lee, Min-Ho
name: Yang, Jeong-Sun
name: Kim, Kyung-Chang
name: Lee, Joo-Yeon
name: Lee, Hansaem
name: Woo, Hye-Min
name: Kim, Jun-Won
name: Choi, Jung-Ah
name: Song, Manki
name: Tomaszewska-Kiecana, Monika
name: Wołowik, Anna
name: Kulesza, Agnieszka
name: Kim, Sunghyun
name: Ahn, Keumyoung
name: Jung, Nahyun
name: Lee, Soo-Young
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant morbidity and mortality worldwide. Despite a successful vaccination programme, the emergence of mutated variants that can escape current levels of immunity mean infections continue. Herein, we report the development of CT-P63, a broad-spectrum neutralizing monoclonal antibody. In vitro studies demonstrated potent neutralizing activity against the most prevalent variants, including Delta and the BA.1 and BA.2 sub-lineages of Omicron. In a transgenic mouse model, prophylactic CT-P63 significantly reduced wild-type viral titres in the respiratory tract and CT-P63 treatment proved efficacious against infection with Beta, Delta, and Omicron variants of SARS-CoV-2 with no detectable infectious virus in the lungs of treated animals. A randomized, double-blind, parallel-group, placebo-controlled, Phase I, single ascending dose study in healthy volunteers (NCT05017168) confirmed the safety, tolerability, and pharmacokinetics of CT-P63. Twenty-four participants were randomized and received the planned dose of CT-P63 or placebo. The safety and tolerability of CT-P63 were evaluated as primary objectives. Eight participants (33.3%) experienced a treatment-emergent adverse event (TEAE), including one grade ≥3 (blood creatine phosphokinase increased). There were no deaths, treatment-emergent serious adverse events, TEAEs of special interest, or TEAEs leading to study drug discontinuation in the CT-P63 groups. Serum CT-P63 concentrations rapidly peaked before declining in a biphasic manner and systemic exposure was dose proportional. Overall, CT-P63 was clinically safe and showed broad-spectrum neutralizing activity against SARS-CoV-2 variants in vitro and in vivo.
Bioexcel Deliverable 3.3 – Consultancy Modalities And Funding Options, Half-Time Update
Creators: name: Carter, Adam
name: Harrow, Ian
Publisher: name: Zenodo
Year: 2017
Subjects: Consultancy

description: In the BioExcel project, we are establishing a Centre of Excellence (CoE) for

Computational Biomolecular Research. We expect the centre to interact with its users in many ways, and part of our work in the “Consultancy and User Groups” work package is to inform the project about ways in which the centre could usefully work with its users and the wider biomolecular community.

This document describes work to date on the evaluation of possible consultancy modalities (that is, ways in which we can offer consultancy) and funding options for these modalities. This document focuses primarily on the former, although it also includes a basic classification of how different modalities could be funded. A second version of this document, due in project month 36, will be more conclusive, and will have a greater emphasis on funding considerations.

Core services, for the wider community are likely to be made available free at the point of use, such as services that are accessed primarily through the project’s web site. Some of these are already offered by the Centre such as discussion forums and a webinar series; others, such as a more formal helpdesk could become more important as the Centre becomes more established. These online services can act as a gateway to more in-depth consultancy.

Face-to-face meetings with users provide a means to interact with users to

provide consultancy, and to listen to the community’s priorities. These include interest group workshops, larger community events and training courses.

With partnerships and collaborations, the Centre would have an agreement with the partner to work together, with both parties making some contribution. In this modality, BioExcel engages with a partner over an extended period of time. This can be through partnerships of varying degrees of formality, through to projects in which BioExcel or its partners apply for funding to work together in a larger project. BioExcel’s consultancy services could also be offered as calls to which users apply, consultations or drop-in services.

Professional services for paying customers provide a means to offer more

expensive and more tailored services to companies and other organisations. The customer relationship differs from that for the wider community. These forms of consultancy must offer clear business value underpinned by a legal contract, and therefore often need to be more targeted towards individual customer organisations. These include tailored technical and scientific support services. Industry partner programmes, software management collectives and precompetitive collaborative alliances are also described.

Work in this area will continue throughout the project, and over the next 18

months we will work with WP5 and ensure that feedback from the Centre’s users and pilot projects feed back into the decision-making processes that will define the Centre’s business plan, and service offering.
PHYSICOCHEMICAL AND SENSORY EVALUATION OF INVASIVE SILVER CARP (Hypophthalmichthys molitrix) FISH NUGGETS
Creators: name: King, Joseph L
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Food sciences not elsewhere classified
Food chemistry and food sensory science

description: Silver carp (Hypophthalmichthys molitrix) are an underutilized, invasive fish threatening native species throughout major water systems in the United States. The goal of this research was to use silver carp meat to create a value-added product, to analyze the changes in physicochemical structure and consumer liking over time, and to evaluate the benefits of adding soy, pea, and a combination of soy and pea protein isolates to the formulations. Fish nuggets were prepared from minced meat in four treatments consisting of 3% soy protein isolate (SPI), 3% pea protein isolate (PPI), a combination of 1.5% SPI and 1.5% PPI, and a control without plant protein isolate. Nuggets from each treatment were stored frozen for 1.5, 8.5, and 13.5 weeks. Proximate composition, pH, cook loss, textural hardness, expressible moisture, color, microbial counts and lipid oxidation were evaluated. Sensory acceptability was also evaluated for each frozen storage time period and treatment. A descriptive (QDA™) trained sensory panel was also conducted on all treatments independent of the storage testing. Results showed that lipid oxidation and textural hardness significantly (P < 0.05) increased with frozen storage time. PPI had significantly lower expressible moisture compared to the control at week 1.5, but there were no statistically significant differences between treatments at weeks 8.5 and 13.5. Similarly, formulations with PPI improved (p<0.05) cook loss for week 1.5, but not week 8.5 or 13.5. Overall, sensory acceptability did not change (P > 0.05), with the exception of decreased degree of liking scores for SPI aroma (p=0.03) and flavor (p=0.03)) during the frozen storage period; all degree of liking scores remained above 6.5 throughout analysis, indicating that consumers’ acceptability of the sample treatments over time despite the changes in physicochemical structure. The descriptive panel created an attribute lexicon for the aroma, flavor, and mouthfeel of the fish nuggets and did not find significant differences in intensities for those attributes between the treatments. Although there were measurable changes in oxidation, texture, expressible moisture, and cook loss over 13.5 weeks, these changes did not impact sensory acceptance. The addition of protein isolates improved water holding capacity initially but did not maintain those benefits over extended shelf life and had little impact on consumer liking during any time period. Overall, this study demonstrated that value-added products such as silver carp nuggets can be created using an otherwise under-utilized fish. The fish nuggets had high sensory acceptability, and the addition of protein isolates did not significantly improve their sensory characteristics; therefore, silver carp nuggets can be formulated without the need of additional protein additives .