title: Ð¥Ð°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð²Ð¸Ð´Ð¾Ð² Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ°ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¿ÑÐ¾Ð»Ð¸Ð½-Ð±Ð¾Ð³Ð°ÑÑÑ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² ÑÐ»ÑÐ½Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Characterization of various types of biological activity of cationic proline-rich salivary peptides
Creators: name: Ð¡ÑÑÐ°ÑÐµÐ²Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð²ÑÐ¾Ð¶Ð´ÑÐ½Ð½ÑÐ¹ Ð¸Ð¼Ð¼ÑÐ½Ð¸ÑÐµÑ
ÑÐ»ÑÐ½Ð°
Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÐµ Ð¿ÐµÐ¿ÑÐ¸Ð´Ñ
Ð¿ÑÐ¾Ð»Ð¸Ð½-Ð±Ð¾Ð³Ð°ÑÑÐµ Ð¿ÐµÐ¿ÑÐ¸Ð´Ñ
Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐ¸Ð½ÐµÑÐ³Ð¸Ð·Ð¼
innate immunity
saliva
antimicrobial peptides
proline-rich peptides
antimicrobial activity
synergyzm

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description: The work is devoted to clarifying the role of cationic proline-rich peptides (PRP) of saliva in the implementation of protective reactions in the oral cavity. The work was carried out at the basis of the laboratory for the design and synthesis of biologically active peptides of the Department of General Pathology and Pathological Physiology of the Institute of Experimental Medicine, where the analyzed peptides were synthesized and the purpose and objectives of the work were formulated. Using the broth microdilution assay, the minimum inhibitory concentrations of peptides were evaluated for Gram-negative and Gram-positive bacteria. Using serial dilutions according to the "checkerboard" method, it was shown that PRP can increase the antibacterial activity of innate immunity peptides present in the oral cavity. The effects of human salivary PRP on the functional activity of human blood leukocytes by flow cytometry and enzyme immunoassay were studied, and new information on the effect of human saliva PRP on the dynamics of wound healing in experimental animals was obtained. During the studies, it was shown that the analyzed cationic proline-rich peptides of human saliva exhibit anti-inflammatory effects, which suggests their significant role in the regulation of inflammatory processes in the oral cavity, as well as their participation in recovery processes.