cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Assessing Ciclosporin in the Treatment of Leprosy Reactions: Evidence from a Randomized Controlled Trial and Other Studies.
Creators: name: Lambert, SM
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2014

description: Leprosy patients present with a spectrum of skin lesions and neuropathy. Despite multi-drug therapy (MDT), which cures the infection, immunological reactions continue to occur, leading to disability and deformity secondary to neuropathy. Reactions are a major cause of morbidity and long term disability. The treatment of reactions is currently inadequate, with prednisolone being the main drug used with partial success and a high rate of side effects. Identifying better agents for treating leprosy reactions is an important clinical need with major service implications.
This work investigated the safety and efficacy of ciclosporin to treat reactions in leprosy patients in Ethiopia. A double-blind randomized controlled clinical trial comparing the efficacy and adverse event profiles of ciclosporin and prednisolone was conducted in patients presenting with Type 1 Reaction. Two similar pilot studies were conducted in patients with Erythema Nodosum Leprosum.
Validating the Type 1 Reaction Severity Scale in Ethiopian patients, assessing features of ENL severity and validating a quality of life questionnaire in Amharic were important preliminary projects to produce valid tools for measuring treatment outcomes.
Patients on ciclosporin and prednisolone had similar clinical outcomes in the treatment of new and chronic Type 1 Reaction. There was a high rate of Type 1 Reaction recurrence in both groups but the patients on ciclosporin required greater amounts of additional prednisolone to control these recurrences. Patients with acute ENL on ciclosporin had a significant 16-week delay in the onset of ENL recurrence. This important difference was not observed in patients with chronic ENL. Prednisolone related adverse events were much more frequent than those related to ciclosporin in all four studies.
sj-docx-6-dhj-10.1177_20552076221085057 - Supplemental material for A COVID-19 forecasting system for hospital needs using ANFIS and LSTM models: A graphical user interface unit
Creators: name: Shafiekhani, Sajad
name: Namdar, Peyman
name: Rafiei, Sima
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111099 Nursing not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 111702 Aged Health Care
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: Anthropology
subject: FOS: Sociology
subject: 200299 Cultural Studies not elsewhere classified
subject: FOS: Other humanities
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences
subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Science Policy
subject: 160512 Social Policy
subject: FOS: Political science
subject: Sociology

description: Supplemental material, sj-docx-6-dhj-10.1177_20552076221085057 for A COVID-19 forecasting system for hospital needs using ANFIS and LSTM models: A graphical user interface unit by Sajad Shafiekhani, Peyman Namdar and Sima Rafiei in Digital Health
title: Cost-Benefit analysis of environmental health interventions: present issues and future steps.
Creators: name: Guerriero, C
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2014

description: Cost-benefit analysis (CBA) can help policy makers and legislators achieve the greatest social good. Despite the potential role that CBA can play, very little has been done to implement CBA of environmental health interventions (EHIs). The overall aim of this thesis is to improve the quality of CBA analyses of EHIs by addressing important research gaps in the literature.
This thesis has four objectives. The first objective is to illustrate a generic framework for CBA of EHIs. The methodological framework described is applied to the economic evaluation of remediating two contaminated industrial sites in Sicily (Gela and Priolo). Including children’s health benefits in CBA is challenging. Compared to adults, children are more vulnerable to environmental hazards, however, due to the lack of child specific willingness to pay (WTP) measures children’s health benefits are often excluded from the analysis or valued using adults WTP measures or cost-of illness estimates.
The second objective of the thesis is to investigate children’s ability to understand WTP questions. In particular, the thesis investigates if children are able to understand health risk and money-related concepts.
The third objective of the thesis is to evaluate child (aged 7-18 years) and parental WTP for reducing children’s environmental health-related risk of asthma attack using both a contingent valuation study (CV) and a discrete choice experiment (DCE).
The fourth objective of the thesis is to estimate the potential benefits to pupils of reducing traffic-related air pollution near primary schools in London using the WTP values quantified in the CV study and environmental and health data collected in London primary schools.
The results of this thesis show that that, despite the high remediation cost, the clean-up of Gela and Priolo in Sicily can be highly cost-effective. The findings of the studies investigating whether children are able to understand WTP questions show that even younger children are able to understand health risk information and money related concepts and that their ability to do so improves with age. Both the CV and the DCE study show that children are able to provide rational answers to WTP questions. Results of the contingent valuation study also show that parents’ WTP estimates differ significantly from those of their children.
Including children’s health benefits and preferences, as demonstrated in the practical case of improving air quality in proximity of London primary schools, gives more accurate and precise estimates of the real benefits arising from EHIs. It also provides a transparent and reliable source of information for decision makers. Findings from this thesis can improve the quality of CBA of EHIs and help future studies provide a sounder basis for policy making.
Geofísica como Ferramenta para Sensoriamento Remoto de Sítios Arqueológicos no Semiárido Brasileiro
Creators: name: Da Silva Santos, João Vitor
name: Nordeste 2020, SAB
name: Ribeiro Barros, Iara
name: Surya, Leandro
Publisher: name: unknown
Year: 2021
Subjects: subject: Archaeology--Data processing
subject: Brazil
subject: Archaeology

description: Trabalho apresentado no Simpósio 10 da VI Reunião da SAB Nordeste 2020
sj-docx-2-tah-10.1177_20406207221088462 – Supplemental material for Changing paradigms of hemophilia care across larger specialized treatment centers in the European region
Creators: name: Windyga, Jerzy
name: Boban, Ana
name: Zupan, Irena
name: O’Connell, Niamh
name: Hermans, Cedric
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Cardiology
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-docx-2-tah-10.1177_20406207221088462 for Changing paradigms of hemophilia care across larger specialized treatment centers in the European region by Jerzy Windyga, Ana Boban, Irena Zupan, Niamh O’Connell and Cedric Hermans in Therapeutic Advances in Hematology
60789: Silk embroidered greetings cards from Trevor Harris
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Greetings cards sent home from France by Trevor Harris, 121 Brg. RFA to family in Aberdare, Glamorgan (NB one in Welsh, 2 in English).

I understand these cards were hand-embroidered by French women in long strips, then they were cut up and backed and sold to the troops.

Some has a little 'pocket' with a small card inside - there is such a small card on one of the images.

Most of the images were flowers, birds, and other sentimental images.

Editor's Comment:

'A Joyful Christmas', farm scene in snow with flowers, holly, and Red Ensign; 'To my Dear Brother', farm and flowers; 'To my Dear Sister', flowers.
Pte. Trevor Harris, 121 Brg. Royal Field Artillery. The 121 Brigade was attached to the 38th (Welsh) Division.
Additional file 1 of Analysis of metabolites in human gut: illuminating the design of gut-targeted drugs
Creators: name: Gil-Pichardo, Alberto
name: Sánchez-Ruiz, Andrés
name: Colmenarejo, Gonzalo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Table S1. Prediction statistics for gut permanence prediction SuperLearner using cluster-based train/test splits. Figure S1. Distribution of ionization states across the four compound sets: DrugBank, and gut metabolites sets at pH = 6.0. Figure S2. Distribution of ionization states across the four compound sets: DrugBank, and gut metabolites sets at pH = 6.4. Figure S3. Distribution of ionization states across the four compound sets: DrugBank, and gut metabolites sets at pH = 7.0
60792: Letter from Dr W.R. Blore M.C. RAMC
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: This is a long letter from Dr W.R. Blore M.C. RAMC sent on 15th March 1916, from Egypt to his Mother. It describes his first leave in Cairo. He describes the city, that the hoteliers etc. must charge the soldiers a set fee, so the officers are able to enjoy quite luxurious accommodation and food etc. Blore describes his first trips to the pyramids and to the ancient tombs.
Also part of this collection are all Blore's letters home, his notebooks from his service as a doctor at Suvla Bay, Gallipoli, and on the Western Front - as well as his sleeping bag and many other artefacts including a photo of Blore outside his dugout at Suvla Bay.
title: Re-annotation of the Campylobacter jejuni NCTC11168 genome and functional characterisation of selected genes involved in strain pathogenesis
Creators: name: Gundogdu, Ozan
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2011

description: Campylobacter jejuni is the leading bacterial cause of foodborne human gastroenteritis worldwide. The first C. jejuni genome (strain NCTC11168) was sequenced in 2000. This original annotation was a milestone in Campylobacter research, but soon became outdated. A re-annotation and re-analysis of this genome sequence was performed resulting in updates to over 90% of coding sequences (CDSs) and modification of 18.2% of CDS product functions (Gundogdu et al., 2007). Following this re-annotation, 15 uncharacterised CDSs with revised functions relating to virulence, signal transduction or regulation of gene expression were selected for further investigation. Defined isogenic C. jejuni 11168H mutants were constructed and after preliminary analysis, the Cj1556 and Cj0248 mutants were selected for further characterisation. Cj1556 was originally annotated as a hypothetical protein and was updated to a MarR family transcriptional regulator. Further bioinformatic analysis indicated a putative role in regulating the oxidative stress response. A C. jejuni 11168H Cj1556 mutant exhibited increased sensitivity to oxidative and aerobic (O2) stress, decreased ability for intracellular survival in both Caco-2 intestinal epithelial cells (IECs) and J774A.1 mouse macrophages and a reduction in virulence in the Galleria mellonella infection model. Microarray analysis of gene expression changes in the Cj1556 mutant compared to the wild-type strain indicated negative autoregulation of Cj1556 expression and down-regulation of genes associated with oxidative and aerobic (O2) stress responses. Cj0248 was originally annotated as a hypothetical protein however the re-annotation identified a HD domain linked to a superfamily of metal-dependent phosphohydrolases with roles in signal transduction in bacteria. Previously a C. jejuni 81-176 Cj0248 mutant was shown to be deficient for motility and chick colonisation, however the exact function of Cj0248 was not investigated. The C. jejuni 11168H Cj0248 mutant also possessed a reduced motility phenotype and exhibited reduced interaction and invasion when co-cultured with Caco-2 IECs compared to the wild-type strain. However the Cj0248 mutant showed no difference in autoagglutination compared to the wild-type strain and TEM analysis indicated the mutant possessed intact flagella. Higher magnification TEM indicated the possibility of an altered flagella basal body region in the Cj0248 mutant. Secretion profile analysis identified no differences in the protein profile of the Cj0248 mutant compared to the wild-type strain. The exact function of Cj0248 remains unclear.
Additional file 1 of Prevalent bee venom genes evolved before the aculeate stinger and eusociality
Creators: name: Koludarov, Ivan
name: Velasque, Mariana
name: Senoner, Tobias
name: Timm, Thomas
name: Greve, Carola
name: Hamadou, Alexander Ben
name: Gupta, Deepak Kumar
name: Lochnit, Günter
name: Heinzinger, Michael
name: Vilcinskas, Andreas
name: Gloag, Rosalyn
name: Harpur, Brock A.
name: Podsiadlowski, Lars
name: Rost, Burkhard
name: Jackson, Timothy N. W.
name: Dutertre, Sebastien
name: Stolle, Eckart
name: von Reumont, Björn M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Additional file 1. Proteo-transcriptomically identified venom components in X. violacea.
Metrics And Tool For Evaluating Data Stream Processing Systems
Creators: name: Gradvohl, Andre Leon Sampaio
Publisher: name: Zenodo
Year: 2018
Subjects: Data Streams Processing Systems
Metrics
Management

description: Presentation at the 5th International Symposium on Intercloud and IoT (ICI 2018). This presentation discusses aspects related to metrics for the evaluation of systems for data streams processing and presents a tool to facilitate the assessment of such systems.
O Georreferenciamento Absoluto Aplicado ao Piauí Colonial
Creators: name: Alves Corrêa, Ângelo
name: Dias Ferreira, Yan
name: Nordeste 2020, SAB
name: van Havre, Grégoire
Publisher: name: unknown
Year: 2021
Subjects: subject: Archaeology--Data processing
subject: Brazil
subject: Archaeology

description: Trabalho apresentado no Simpósio 10 da VI Reunião da SAB Nordeste 2020
Additional file 2 of Circular RNA CCT3 is a unique molecular marker in bladder cancer
Creators: name: Luo, Lin
name: Xie, Qingzhi
name: Wu, Yunchou
name: Li, Ping
name: Qin, FuQiang
name: Liao, Dunming
name: Wang, KangNing
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 2
Increasing root carbon input to agricultural soils by variety selection
Creators: name: Heinemann, Henrike
name: Hirte, Juliane
name: Seidel, Felix
name: Don, Axel
Publisher: name: Zenodo
Year: 2023

description: Choosing varieties that produce more root biomass can lead to additional carbon input in soils. This might help carbon accrual but could also reduce yields.
sj-docx-1-jmh-10.1177_15579883221087531 – Supplemental material for HIV-Related Stigma, Sexual Identity, and Depressive Symptoms Among MSM Living With HIV in China: A Moderated Mediation Modeling Analysis
Creators: name: Mi, Tianyue
name: Lan, Guanghua
name: Yang, Xueying
name: Li, Xiaoming
name: Qiao, Shan
name: Shen, Zhiyong
name: Zhou, Yuejiao
Publisher: name: SAGE Journals
Year: 2022
Subjects: Health and Community Services
Nursing not elsewhere classified
Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-jmh-10.1177_15579883221087531 for HIV-Related Stigma, Sexual Identity, and Depressive Symptoms Among MSM Living With HIV in China: A Moderated Mediation Modeling Analysis by Tianyue Mi, Guanghua Lan, Xueying Yang, Xiaoming Li, Shan Qiao, Zhiyong Shen and Yuejiao Zhou in American Journal of Men's Health
sj-docx-1-aor-10.1177_00034894221094950 – Supplemental material for Evaluation of Preference and Utility Measures for Transoral Thyroidectomy
Creators: name: Wu, Vincent
name: Samargandy, Shireen
name: Philteos, Justine
name: Pasternak, Jesse D.
name: de Almeida, John R.
name: Monteiro, Eric
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-aor-10.1177_00034894221094950 for Evaluation of Preference and Utility Measures for Transoral Thyroidectomy by Vincent Wu, Shireen Samargandy, Justine Philteos, Jesse D. Pasternak, John R. de Almeida and Eric Monteiro in Annals of Otology, Rhinology & Laryngology
Gênero e Arqueologia: perspectivas desde o Nordeste
Creators: name: Almeida Araújo Nogueira, Mônica
name: Cavalcanti de Castro, Viviane Maria
name: Nordeste 2020, SAB
name: Zanchetta Otaviano, Mariana
Publisher: name: unknown
Year: 2021
Subjects: subject: Brazil
subject: Archaeology

description: Descrição do Simpósio 11 da VI Reunião da SAB Nordeste 2020
Lab-on-CMOS-Capacitance Sensor Array for Real-Time Cell Viability Measurements
Creators: name: Dasgupta, Prithwish
name: Nielsen, Kyle
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: CMOS
Lab-on-CMOS
Lab-on-chip
Cell Viability
Capacitance Sensor
Electrical Engineering
Biosensor

description: This project addresses the need to enhance the functionality and reusability of existing CMOS chips for monitoring cell viability and facilitating visual inspection. The primary challenge tackled is the reduction of research downtime due to inefficient sensor replacement and the improvement of data collection methods. To achieve this, the project integrates PCB design software, CAD software, and programming languages, including VHDL, C, and MATLAB. PCB design is utilized to create strategic board configurations aimed at streamlining the data collection process and ensuring the creation of a reliable and replaceable cell viability measurement device. These methods synergistically enhance CMOS chip functionality and usability, with a focus on streamlining packaging, facilitating hot-swappable system development, and establishing a data readout system. Key achievements encompass the development of a hot-swappable system for effortless CMOS chip replacement, streamlined packaging to bolster chip longevity, and the establishment of a real-time data readout system. These advancements notably enhance research efficiency and data quality by minimizing downtime and improving the correlation of capacitance measurements with direct visual observations of cell behavior. In the broader context of lab-on-a-chip technology and sensor development, these achievements deepen our understanding of cell behavior and expedite progress in drug screening, disease diagnostics, and tissue engineering. The integrated approach presented in this research marks a significant advancement in pushing the boundaries of lab-on-a-chip technology and its applications in biomedical research.
Grupo de Afoxé Raízes Africanas na Perspectiva Mulherismo Africana
Creators: name: Lima, Vanderleia
name: Nordeste 2020, SAB
Publisher: name: unknown
Year: 2021
Subjects: subject: Brazil
subject: Archaeology

description: Trabalho apresentado no Simpósio 11 da VI Reunião da SAB Nordeste 2020
Additional file 1 of Association between intraoperative pulmonary artery pressure and cardiovascular complications after off-pump coronary artery bypass surgery: a single-center observational study
Creators: name: Matsuo, Mitsuhiro
name: Doi, Toshio
name: Katsuki, Masahito
name: Yoshimura, Yuichiro
name: Ito, Hisakatsu
name: Fukahara, Kazuaki
name: Yoshimura, Naoki
name: Yamazaki, Mitsuaki
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biological Sciences not elsewhere classified
Science Policy

description: Additional file 1.
Effects of Plastic Bag Regulations on the Chesapeake Bay
Creators: name: Muthyam, Lasya
name: Peddinti, Sriya
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: First Year Innovation and Research Experience (FIRE)
Sustainability Analytics
Data Science
Technology

description: Microplastic pollution in waterways poses a critical environmental challenge worldwide by having long lasting effects on wildlife, human health, and ecological balance. To address this issue, many local governments have implemented plastic bag bans as a mitigation measure. This research investigates the effectiveness of such policies in reducing microplastic levels within the Chesapeake Bay Watershed by drawing data from the USGS Water and Chesapeake Bay Data Hub. After merging plastic ban status from each county’s website with water quality data, we examined changes in particulate inorganic carbon and total organic nitrogen levels across various locations surrounding the Chesapeake Bay. Previous research reveals that higher levels of microplastics in water typically increases the amount of organic nitrogen present in the water and decreases the amount of inorganic carbon found in the water. Since our current data contains water quality up until 2021, Harford county is the only county with an effective plastic ban. Because of this, we do not yet have conclusive evidence regarding the effectiveness of plastic bans on microplastic pollution levels. Despite inconclusive findings, this study underscores the importance of addressing microplastic pollution for environmental sustainability and underscores the need for further investigation to inform policy-making and conservation efforts.
Additional file 1 of Methodological and reporting quality of systematic reviews on health effects of air pollutants were higher than extreme temperatures: a comparative study
Creators: name: Song, Xuping
name: Luo, Qiyin
name: Jiang, Liangzhen
name: Ma, Yan
name: Hu, Yue
name: Han, Yunze
name: Wang, Rui
name: Tang, Jing
name: Guo, Yiting
name: Zhang, Qitao
name: Ma, Zhongyu
name: Zhang, Yunqi
name: Guo, Xinye
name: Fan, Shumei
name: Deng, Chengcheng
name: Fu, Xinyu
name: Chen, Yaolong
name: Yang, Kehu
name: Ge, Long
name: Wang, Shigong
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Science Policy
Developmental Biology

description: Supplementary Material 1
58317: Effects Issue Form
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Effects issue form of William Binning.
2nd Lieutenant William B. Binning (1896 - 1916), Scottish Rifles 9th Div. Machine Gun Corps, 28th Bn.
Creating Dcr-Matched Templates For Image Differencing
Creators: name: Sullivan, Ian
Publisher: name: Zenodo
Year: 2017
Subjects: lsst
Image differencing
Differential Chromatic Refraction

description: The frequency-dependent spectral index of the atmosphere leads to spectrum-dependent distortions of sources away from zenith. While the effect of bulk refraction is easily corrected during astrometric calibration, this Differential Chromatic Refraction (DCR) introduces distortions that depend on the intrinsic spectrum of a source and vary with the parallactic angle and airmass of the observation. Past surveys have avoided DCR by restricting observations to low airmass, but LSST operations will require observations up to an airmass of 1.4 across the sky and up to 2 in some fields. With current image differencing techniques, we would have to choose between a high rate of false positive detections that would have to be culled with machine learning, or restrict template images to have similar airmasses and parallactic angles of the science image. However, the refraction of the atmosphere has been modeled for decades with increasing refinement, and we can use iterative forward modeling to estimate a sky model using that knowledge of the atmosphere to fit all observations of a patch simultaneously. We use this model to calculate new DCR-matched templates for image differencing, and find that it reduces the number of spurious source detections in DECam g-band images.
Functional characterization of nuclear receptor NR1D1 on investigation of brain metastasis
Creators: name: Berroya, Arryn Joeina Mercado
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: cancer
pharmacology
metastasis
breast cancer
American Cancer Society Diversity in Cancer Research (ACS-DICR)
CMNS
UMSOM-UMGCCC

description: Brain metastasis is a fatal recurrence of advanced cancer that affects 20% of cancer patients. Capturing comprehensive brain metastasis landscape is critical to the establishment of sufficient and effective anti-tumor strategies. Ongoing research efforts in our team aim to better understand the biology of tumor cells in human brain metastasis. Preliminary data, generated by single cell sequencing of human brain metastases highlighted a potential role of the nuclear receptor NR1D1. Indeed, NR1D1 activity seems to be correlated with proliferation, immune evasion, and metabolism of brain metastatic tumor cells. The activity of this nuclear receptor can be controlled by its ligand Hemin (HEME) and is critical in retaining control of the circadian rhythm. Our aim is to investigate the functional properties of NR1D1 itself through breast cancer cell lines. Breast cancer cell lines, SUM190, MDA-MB-231 and JIMT1 were used to study NR1D1 function and undergone multiple treatments with conditions that consisted of exposing HEME and a synthetic agonist in various incubation times while adjusting media with no FBS, essentially starving the cells from creating their own HEME. In publicly available data sets it was found that low NR1D1 expression correlated with increase of Triradylglcerols metabolism and high NR1D1 expression with increase of amino acids and peptide metabolism. In addition, our data suggests that NR1D1 activation leads to cell morphology changes and future experiments will determine whether NR1D1 influences tumor cell proliferation and immune invasion. This will assist in determining discrete phenotypes of brain metastatic tumor cells and new approaches for treatment.
title: Informationen aus der Forschung des BBSR 1/2025
Creators: name: Bundesinstitut für Bau-, Stadt- und Raumforschung
Publisher: name: Bundesinstitut für Bau-, Stadt- und Raumforschung
publisherIdentifier: https://ror.org/01zy7yh11
publisherIdentifierScheme: ROR
Year: 2025
Subjects: classificationCode: 5.7
subject: FOS: Social and economic geography

description: Hohe Energiepreise verteuern das Wohnen. Viele Haushalte hat der drastische Anstieg der Energiepreise in den Jahren 2022 und 2023 dazu veranlasst, ihren Verbrauch zu überdenken. Eine aktuelle Untersuchung zeigt, dass insbesondere Selbstnutzer von Eigentumswohnungen ihre Gas- und Ölheizkosten erheblich senken konnten. Allerdings verdeutlicht die Analyse auch, dass Mieterhaushalte weniger Einfluss auf Einsparmaßnahmen haben als Eigentümerinnen und Eigentümer.
Parallel dazu fehlt es gerade in den wirtschaftsstarken Räumen an günstigem Wohnraum. Hohe Mieten und ein begrenztes Angebot erschweren es insbesondere Fachkräften, bezahlbaren Wohnraum zu finden. Unternehmen übernehmen deshalb zunehmend Verantwortung, um ihre Mitarbeitenden zu unterstützen. Eine aktuelle Erhebung zeigt,
dass bereits rund 5 % der Unternehmen ihren Beschäftigten direkt Wohnraum anbieten, während knapp 12 % auf indirekte Maßnahmen wie Tauschbörsen oder Zuschüsse setzen.
Angesichts des anhaltenden Fachkräftemangels gewinnt das Thema Mitarbeiterwohnen weiter an Bedeutung.
Neben klassischen statistischen Erhebungen spielt künstliche Intelligenz eine immer wichtigere Rolle in der Analyse
räumlicher Entwicklungen. Im Projekt „Innovationslabor Daten und Analysen“ (IDA) des BBSR kommen KI-Technologien
zum Einsatz, um aus unstrukturierten Daten wertvolle Erkenntnisse zu gewinnen. Solche Methoden ergänzen die amtliche Statistik und ermöglichen ein schnelleres Monitoring wirtschaftlicher und sozialer Entwicklungen.
sj-docx-3-tah-10.1177_20406207221084487 – Supplemental material for A retrospective real-world study of the current treatment pathways for myelofibrosis in the United Kingdom: the REALISM UK study
Creators: name: Mead, Adam J.
name: Butt, Nauman M.
name: Nagi, Waseem
name: Whiteway, Alastair
name: Kirkpatrick, Suriya
name: Rinaldi, Ciro
name: Roughley, Catherine
name: Ackroyd, Sam
name: Ewing, Joanne
name: Neelakantan, Pratap
name: Garg, Mamta
name: Tucker, David
name: Murphy, John
name: Patel, Hitesh
name: Bains, Rozinder
name: Chiu, Gavin
name: Hickey, Joe
name: Harrison, Claire
name: Somervaille, Tim C. P.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Cardiology
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-docx-3-tah-10.1177_20406207221084487 for A retrospective real-world study of the current treatment pathways for myelofibrosis in the United Kingdom: the REALISM UK study by Adam J. Mead, Nauman M. Butt, Waseem Nagi, Alastair Whiteway, Suriya Kirkpatrick, Ciro Rinaldi, Catherine Roughley, Sam Ackroyd, Joanne Ewing, Pratap Neelakantan, Mamta Garg, David Tucker, John Murphy, Hitesh Patel, Rozinder Bains, Gavin Chiu, Joe Hickey, Claire Harrison and Tim C. P. Somervaille in Therapeutic Advances in Hematology
Twelve Meditations on Venture Capital
Creators: name: Murray, Gordon
name: Lingelbach, David C
Publisher: name: Maryland Shared Open Access Repository
Year: 2010

description: This paper reflects on the policy formation process in the burgeoning area of venture capital finance. An important question is raised as to why so little extant academic research, of both rigor and relevance, is employed in policy formation. The authors argue that the long term, international and comparative perspective of the academic researcher is of increasing importance in government. The gap between policy practice and academic empiricism is illustrated by reference to contemporary policy interest in the creation of public/private (‘hybrid’) venture capital funds. The rubric of 12 Meditations is employed as a device to communicate across the academic/policy maker divide.
description: https://www.researchgate.net/profile/Gordon_Murray3/publication/280527370_Murray_GC_and_Lingelbach_D_2010_%27Twelve_Meditations_on_Venture_Capital%27_in_Companion_to_Venture_Capital_Cumming_D_ed_New_York_John_Wiley_Sons_Inc/links/55b7603608ae092e965712c7/Murray-GC-and-Lingelbach-D-2010-Twelve-Meditations-on-Venture-Capital-in-Companion-to-Venture-Capital-Cumming-D-ed-New-York-John-Wiley-Sons-Inc.pdf
ИССЛЕДОВАНИЕ МИНЕРАЛЬНЫЕ СОСТАВА  ШАЛФЕЯ  МУСКАТНОГО ( SALVIA SCLAREA L)
Creators: name: Эшназарова, Н.Х.
name: Пулатова, Д.К.
name: Урманова, Ф.Ф.
Publisher: name: Zenodo
Year: 2024

description: Как известно минеральные вещества выполняют пластическую функцию в процессе жизнедеятельности человека , участвуя в построении тканей, поддержании кислотно-осовного обмена, определении состояния свертывающей системы крови. Без участия минеральных веществ невозможны многие ферментативные процессы в организме [1].
60794: Letter from Dr W.R. Blore M.C. RAMC
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: This is a short letter from Dr W.R. Blore M.C. RAMC sent on 22nd April 1916, from Egypt to his Mother. It describes how he has finally washed his sleeping bag.
That sleeping bag is visible in a photo of Dr Blore outside his dugout at Suvla Bay, Gallipoli in 1915, and mentioned in letters.
Also part of this collection are all Blore's letters home, his notebooks from his service as a doctor at Suvla Bay, Gallipoli, and on the Western Front - as well as this sleeping bag and many other artefacts.
Soil Carbon - the blind spot of European national GHG Inventories
Creators: name: Bellassen, Valentin
name: Angers, Denis
name: Kowalczewski, Tomasz
name: Olesen, Asger
Publisher: name: Zenodo
Year: 2022

description: As long as soil carbon is not properly monitored, it will not be possible to identify the priority areas where new removals can be targeted and incentivized.
Additional file 2 of Methodological and reporting quality of systematic reviews on health effects of air pollutants were higher than extreme temperatures: a comparative study
Creators: name: Song, Xuping
name: Luo, Qiyin
name: Jiang, Liangzhen
name: Ma, Yan
name: Hu, Yue
name: Han, Yunze
name: Wang, Rui
name: Tang, Jing
name: Guo, Yiting
name: Zhang, Qitao
name: Ma, Zhongyu
name: Zhang, Yunqi
name: Guo, Xinye
name: Fan, Shumei
name: Deng, Chengcheng
name: Fu, Xinyu
name: Chen, Yaolong
name: Yang, Kehu
name: Ge, Long
name: Wang, Shigong
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Science Policy
Developmental Biology

description: Supplementary Material 2
60805: Percy Watson
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Attached are photographs of Corporal Percy Watson, who originally enlisted with the 7th Battlion, Mancheser Regiment and then was merged into the East Lancashire Regiment towards the end of the war. The 7th Manchester Regiment was a Terattorial Regiment and as Percy was a butcher by trade, it is believed that he was the Butcher to the regiment.
Percy was born on the 27th August 1888 in Burnley to Alfred Watson and Ellen Walters. He married Bertha Lakin on the 16th November 1908 in Chorlton cum Hardy, Manchester. They had two children, Stanley, born in 1909 and Marjorie born in 1912. She is still alive but has limited memories of her father as she was six at the time of his death.
Attached are letters to his wife Bertha, including one written the day he was killed.
There is a detailed letter stating how Percy was killed, his death certificate, letters from the Commonwealth War Graves on both his burial and re burial and a very heartfelt letter written in August 1918 where he is clearly very certain that he will die in the trenches.
There are also postcards from Percy's children and his wife for his birthday. These have shrapnel holes through them as he had them on his person when he was killed. Pictures are also attached of Percy and his family
Parental support and artistic creativity at the beach: an observational approach
Creators: name: Pattanaik, Sragvi
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: subject: Psychology
subject: FOS: Psychology
subject: BSOS

description: Artistic creativity is the production of novel resources that contribute to the arts (Chemi, 2017) and can be integral towards improving the mental health of both artists and consumers of art. When studying factors that may contribute to artistic creativity, parenting may be an important consideration. Supportive parenting contributes to child development by practicing parental sensitivity, cognitive stimulation to learning, and unconditional love (Lin, 2023), and may encourage children to find healthy ways of expressing their emotions artisitically. An observational research design was conducted to assess the relationship between parental support and artistic creativity. We hypothesized that children with parental supervision engage in artistic hobbies more frequently compared to children without supervision. A total of 60 young children were observed for a minute each on a web camera featuring the coast of Maho Beach in Sint Marten. Parental supervision was coded as present if a child was present alongside a guardian and artistic creativity was measured, based on if participants engaged in artistic hobbies. Contrary to predictions, results indicate that children with parental supervision do not engage in artistic hobbies more frequently than children without supervision. Lack of statistical support for the relationship between parenting and creativity may be due to limited time in observing participants and using parental supervision as an indicator for parental support. Future research should be conducted with longer observation periods and coding for different kinds of parental support towards children.
Gênero no Baixo São Francisco Pré-Colonial: Uma Breve Análise sobre o Sítio Arqueológico Justino
Creators: name: Barreto Da Silva, Amanda
name: Nordeste 2020, SAB
Publisher: name: unknown
Year: 2021
Subjects: subject: Brazil
subject: Archaeology

description: Trabalho apresentado no Simpósio 11 da VI Reunião da SAB Nordeste 2020
60753: Photo of Reg Cole, and landlady's family
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Photograph sent as a postcard by Reg Cole to his cousin Charles W. Carr. Both served with the Gloucestershire Regiment (in this postcard Reg (service no. 1844) writes from C Company (1/)5th Glos. to Charles in C Company 2/5th, at Northampton). The message explains that when Reg and his company move on Charles will soon be coming to Chelmsford. Reg is standing on left in this photograph.

Private 1844 Reginald William Cole, 'C' Coy., 5th Bn. Gloucestershire Regiment, died 12th May 1915, aged 22. The son of Abraham Noden Cole and Minnie Rosetta Cole, of 12, Clarence Square, Cheltenham. Born at Skenfrith, he is buried in Ploegsteert Wood Military Cemetery.

Part of large collection of photos and memoribilia relating to Serjeant 3091 (later 240965) Charles Woodward Carr, 2/5th Battalion Gloucestershire Regiment - kept by Mrs Gill Porter and Mr Tony Carr of their father.
Pretas Memórias: As Mulheres Diaspóricas Negras e seus Cachimbos
Creators: name: De Lima Nascimento, Sofia
name: Nordeste 2020, SAB
Publisher: name: unknown
Year: 2021
Subjects: subject: Brazil
subject: Archaeology

description: Trabalho apresentado no Simpósio 11 da VI Reunião da SAB Nordeste 2020
Using Synthetic HSV to Study Viral Pathogenesis and Develop Cancer Therapeutics
Creators: name: Duggal, Aryaan
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: synthetic biology
oncology
cancer biology
virology
pathogen-host interactions

description: Background: Herpes Simplex Virus 1 (HSV-1) is a linear dsDNA virus typically associated with ulcer development in the mouth and genital mucous membranes. Often overlooked, is the versatile DNA structure that enables HSV-1 to serve as a platform to study viral pathogenesis. HSV-1 also possesses an inherent oncolytic quality, allowing it to function as a selective therapeutic that can be programmed to target malignant cells while inducing a strong host immune response. Methods: Various endonucleases were used to isolate the genome into 11 smaller fragments. To study the effects on viral pathogenicity and oncolytic properties, we synthesized and inserted novel sequences, with a YCpBAC sequence to allow for selection and transformation into yeast spheroplasts for TAR cloning in vitro. Fragments containing Casp2 coding regions were also tested for viability, by running quantification assays and infection tests on cell lineages. Results: Isolated band size was correlated with theoretical values, indicating accurate construction of all HSV-1 fragments. After screening on -His and -Ura plates, a 200µL aliquot of 40ng/µL TAR2 sample was determined to yield a satisfactory 85% success rate in yeast assembly. The ideal quantity for viral replication in Vero E6 cells was determined to be around 1.0×10^7 cells/cm^2 providing 2.5ml of 100x viral solution. Conclusions: Successful reassembly of HSV-1 demonstrates the feasibility of using HSV-1 as a therapeutic vehicle, useful in treating cancers and understanding neurological diseases. These findings provide a strong foundation for subsequent modifications of HSV-1, which will focus on its effects on a variety of cancer cell lines.
Using a long-term data set from Ohio to analyze climate change and it’s impacts on phenology and ecological interactions
Creators: name: DeVan, Caroline
Publisher: name: QUBES
Year: 2017

description: This is an FMN participant modification of the TIEE module "Investigating the footprint of climate change on phenology and ecological interactions in north-central North America," authored by Kellen Calinger in 2014.
Additional file 1 of A high-quality chromosome-level Eutrema salsugineum genome, an extremophile plant model
Creators: name: Xiao, Meng
name: Hao, Guoqian
name: Guo, Xinyi
name: Feng, Landi
name: Lin, Hao
name: Yang, Wenjie
name: Chen, Yanyu
name: Zhao, Kexin
name: Xiang, Ling
name: Jiang, Xinyao
name: Mei, Dong
name: Hu, Quanjun
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
La finance comportementale : un enjeu pour les fonds de pension
Creators: name: Moumni, Nicolas
name: Duneufgermain, Caroline
Publisher: name: Critique économique
Year: 2014
Subjects: modélisation ; finance comportementale ; théorie de l’efficience des marchés financiers.

description: L’originalité théorique de la finance comportementale consiste notamment en la prise en compte des comportements individuels ne répondant pas à ceux attendus par l’hypothèse de rationalité induite par la théorie des marchés efficients. Cela se traduit également dans une modélisation particulière. Cette modélisation a pris forme grâce à la Théorie comportementale du portefeuille (Behavioral Portfolio Theory ou BPT) introduite par Shefrin et Statman (2000). Dès lors, elle offre la possibilité à ce cadre cognitif alternatif à la Théorie de l’efficience des marchés financiers de passer d’un statut explicatif à un statut opératoire par le développement de ces outils de modélisation. En effet, par ce biais, la finance comportementale dépasse la critique du simple exposé de biais comportementaux. Elle permet une tentative d’utilisation empirique de ces éléments théoriques comme par exemple dans le processus de prise de décision d’investissement des fonds de pension. Ces derniers deviennent des investisseurs institutionnels de plus en plus importants dans les économies émergentes développant leur espace financier, comme au Maroc. Cette contribution offre un développement détaillé du modèle BPT en lien avec l’état de l’art de la finance comportementale.
description: Critique économique, No 28-29 (2012)
O Imaginário da "Mulher Solteira": Um Estudo Arqueológico nos Bordéis das Vilas da Cia. Ford na Amazônia Paraense
Creators: name: Allen, Scott Joseph
name: Ferreira, Daniela Aparecida
name: Nordeste 2020, SAB
Publisher: name: unknown
Year: 2021
Subjects: subject: Brazil
subject: Archaeology

description: Trabalho apresentado no Simpósio 11 da VI Reunião da SAB Nordeste 2020
title: "Cavaspina", ambito romano, inv. CLXXVI (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Felici, Sonja
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Observational Study: Good Nutrition and Psychological Well-Being
Creators: name: Chavan, Sidharth
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: subject: Psychology
subject: FOS: Psychology
subject: BSOS

description: Psychological well-being appears important to one’s sense of fulfillment and harmony in life as psychological well-being may include positive emotions, life satisfaction, personal growth, and a sense of purpose. Previous research has found a link between adequate nutrition and higher psychological well-being (Veenhoven, 2019). Building on this research, this study aims to explore the relationship between restaurant choice and psychological well-being among University of Maryland students. A naturalistic observational research design was used to assess if students who choose healthier restaurants, such as Saladworks or Qdoba, exhibited greater psychological well-being behaviors such as smiling, laughing, and sitting upright rather than slouched, compared to those who opted for unhealthier establishments, such as Union Pizza or Chick Fil A. As predicted, students who frequent healthier restaurants demonstrated significantly more signs of psychological well-being. These findings could have implications for mental health advocates, highlighting the importance of promoting healthier eating habits among college students. Implementations of these findings can be used to support social media campaigns raising awareness of disproportionately high prices of healthy food and the promotion of making healthy food more affordable. Future research could further explore this relationship experimentally, potentially leading to interventions aimed at improving psychological well-being through dietary choices.
Additional file 1 of Mobile service delivery in response to the opioid epidemic in Philadelphia
Creators: name: Stewart, Rebecca E.
name: Christian, Hanna P.
name: Cardamone, Nicholas C.
name: Abrams, Catherine
name: Drob, Caroline
name: Mandell, David S.
name: Metzger, David
name: Lowenstein, Margaret
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Mobile OUD Care Unit Interview and Notes.
sj-pdf-2-jpe-10.1177_0739456X221082502 – Supplemental material for Pedagogy of Planning Studios for Multidisciplinary, Research-Oriented, Personalized, and Intensive Learning
Creators: name: Galan, Juanjo
name: Kotze, D. Johan
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-2-jpe-10.1177_0739456X221082502 for Pedagogy of Planning Studios for Multidisciplinary, Research-Oriented, Personalized, and Intensive Learning by Juanjo Galan and D. Johan Kotze in Journal of Planning Education and Research