cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Probing the Structure of NaYF₄ Nanocrystals using Synchrotron-Based Energy-Dependent X-ray Photoelectron Spectroscopy
Creators: name: Pichaandi, Jothirmayanantham
name: Das, Gautom Kumar
name: Johnson, Noah J. J.
name: Regier, Tom
name: Van Veggel, Frank C. J. M.
Publisher: name: ACS
Year: 2014

description: Understanding the structure and chemical speciation of the synthesized lanthanide-doped NaYF₄ nanocrystals is of paramount importance to improve and optimize their physical and chemical properties. Hence in this work we employ synchrotron-based high-resolution X-ray photoelectron spectroscopy (XPS) measurements to analyze lanthanide-doped and undoped NaYF₄ nanocrystals. These measurements revealed that there are two doublets for the yttrium ions in the nanocrystal instead of the single doublet in case all Y³⁺ ions have the same chemical environment, generally observed around a binding energy of 160 eV (3d photoelectrons of Y³⁺). This second doublet (binding energy ∼ 157.5 eV) was convoluted with the first doublet (binding energy ∼ 160 eV), and the intensity of this doublet increased with a decrease in excitation X-ray energy. The second doublet was confirmed to belong to the yttrium ions as doped and undoped NaYF₄ nanocrystals exhibit this second peak. The peaks were deconvoluted showing that the second peak is also a doublet with the ratio of the peaks being 2:3. This is exactly the same as what we have observed for the first doublet of the 3d photoelectrons of yttrium ions. In addition, we observe an increase in intensity of the second doublet in comparison to the original 3d doublet of the yttrium ions as the excitation energy is decreased. This suggests that the second doublet is from surface yttrium ions in the NaYF₄ nanocrystal. To confirm our hypothesis, a shell of NaYbF₄ or NaTmF₄ was grown over the NaYF₄ nanocrystal and the second doublet for the yttrium ions was not observed. This is an additional confirmation that the second doublet is indeed from the surface yttrium ions. This implies that the yttriums on the surface of the nanocrystals have a (slightly) different chemical speciation than their counterparts inside the nanocrystals. We attribute the new chemical speciation of surface yttrium ions to the different chemical environment they encounter than their counterparts inside the nanocrystal.
Influence of Particle Size on Persistence and Clearance of Aerosolized Silver Nanoparticles in the Rat Lung
Creators: name: Anderson, Donald S.
name: Patchin, Esther S.
name: Silva, Rona M.
name: Uyeminami, Dale L.
name: Sharmah, Arjun
name: Guo, Ting
name: Das, Gautom Kumar
name: Brown, Jared M.
name: Shannahan, Jonathan
name: Gordon, Terry
name: Chen, Lung Chi
name: Pinkerton, Kent E.
name: Winkle, Laura S. Van
Publisher: name: Oxford University Press
Year: 2015
Subjects: lung
inhaled
engineered nanomaterials
macrophage
inhalation

description: The growing use of silver nanoparticles (AgNPs) in consumer products raises concerns about potential health effects. This study investigated the persistence and clearance of 2 different size AgNPs (20 and 110 nm) delivered to rats by single nose-only aerosol exposures (6 h) of 7.2 and 5.4 mg/m3, respectively. Rat lung tissue was assessed for silver accumulations using inductively-coupled plasma mass spectrometry (ICP-MS), autometallography, and enhanced dark field microscopy. Involvement of tissue macrophages was assessed by scoring of silver staining in bronchoalveolar lavage fluid (BALF). Silver was abundant in most macrophages at 1 day post-exposure. The group exposed to 20 nm AgNP had the greatest number of silver positive BALF macrophages at 56 days post-exposure. While there was a significant decrease in the amount of silver in lung tissue at 56 days post-exposure compared with 1 day following exposure, at least 33% of the initial delivered dose was still present for both AgNPs. Regardless of particle size, silver was predominantly localized within the terminal bronchial/alveolar duct junction region of the lung associated with extracellular matrix and within epithelial cells. Inhalation of both 20 and 110 nm AgNPs resulted in a persistence of silver in the lung at 56 days post-exposure and local deposition as well as accumulation of silver at the terminal bronchiole alveolar duct junction. Further the smaller particles, 20 nm AgNP, produced a greater silver burden in BALF macrophages as well as greater persistence of silver positive macrophages at later timepoints (21 and 56 days).
Pairing correlations across the superfluid phase transition in the unitary Fermi gas
Creators: name: Jensen, S.
name: Gilbreth, C. N.
name: Alhassid, Y.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In the two-component Fermi gas with a contact interaction, a pseudogap regime can exist at temperatures between the superfluid critical temperature $T_c$ and a temperature $T^* > T_c$. This regime is characterized by pairing correlations without superfluidity. However, in the unitary limit of infinite scattering length, the existence of this regime is still debated. To help address this, we have applied finite-temperature auxiliary-field quantum Monte Carlo (AFMC) to study the thermodynamics of the superfluid phase transition and signatures of the pseudogap in the spin-balanced homogeneous unitary Fermi gas. We present results at finite filling factor $ν\simeq 0.06$ for the condensate fraction, an energy-staggering pairing gap, the spin susceptibility, and the heat capacity, and compare them to experimental data when available. In contrast to previous AFMC simulations, our model space consists of the complete first Brillouin zone of the lattice, and our calculations are performed in the canonical ensemble of fixed particle number. The canonical ensemble AFMC framework enables the calculation of a model-independent gap, providing direct information on pairing correlations without the need for numerical analytic continuation. We use finite-size scaling to estimate $T_c$ at the corresponding filling factor. We find that the energy-staggering pairing gap vanishes above $T_c$, showing no pseudogap effects, and that the spin susceptibility shows a substantially reduced signature of a spin gap compared to previously reported AFMC simulations.
description: 5 pages, 2 figures, and 6 pages, 9 figures of supplemental material
Microscopic Restoration of Proton-Neutron Mixed Symmetry in Weakly Collective Nuclei
Creators: name: Holt, J. D.
name: Pietralla, N.
name: Holt, J. W.
name: Kuo, T. T. S.
name: Rainovski, G.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Starting from the microscopic low-momentum nucleon-nucleon interaction V{low k}, we present the first systematic shell model study of magnetic moments and magnetic dipole transition strengths of the basic low-energy one-quadrupole phonon excitations in nearly-spherical nuclei. Studying in particular the even-even N=52 isotones from 92Zr to 100Cd, we find the predicted evolution of the predominantly proton-neutron non-symmetric state reveals a restoration of collective proton-neutron mixed-symmetry structure near mid-shell. This provides the first explanation for the existence of pronounced collective mixed-symmetry structures in weakly-collective nuclei.
description: 5 Pages, 3 figures
Diverse nuclear star-forming activities in the heart of NGC 253 resolved with ten-pc scale ALMA images
Creators: name: Ando, Ryo
name: Nakanishi, Kouichiro
name: Kohno, Kotaro
name: Izumi, Takuma
name: Martin, Sergio
name: Harada, Nanase
name: Takano, Shuro
name: Kuno, Nario
name: Nakai, Naomasa
name: Sugai, Hajime
name: Sorai, Kazuo
name: Tosaki, Tomoka
name: Matsubayashi, Kazuya
name: Nakajima, Taku
name: Nishimura, Yuri
name: Tamura, Yoichi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an 8 pc x 5 pc resolution view of the central ~ 200 pc region of the nearby starburst galaxy NGC 253, based on ALMA Band 7 (λ ~ 0.85 mm or ν ~ 350 GHz) observations covering 11 GHz. We resolve the nuclear starburst of NGC 253 into eight dusty star-forming clumps, 10 pc in scale, for the first time. These clumps, each of which contains (4-10) x 10^4 M_sun of dust (assuming that the dust temperature is 25 K) and up to 6 x 10^2 massive (O5V) stars, appear to be aligned in two parallel ridges, while they have been blended in previous studies. Despite the similarities in sizes and dust masses of these clumps, their line spectra vary drastically from clump to clump although they are separated by only ~ 10 pc. Specifically, one of the clumps, Clump 1, exhibits line confusion-limited spectra with at least 36 emission lines from 19 molecules (including CH3OH, HNCO, H2CO, CH3CCH, H2CS, and H3O+) and a hydrogen recombination line (H26α), while much fewer kinds of molecular lines are detected in some other clumps where fragile species, such as complex organic molecules and HNCO, completely disappear from their spectra. We demonstrate the existence of hot molecular gas ($T_rot (SO2) = 90 {\pm} 11 K) in the former clump, which suggests that the hot and chemically rich environments are localized within a 10-pc scale star-forming clump.
description: 15 pages, 5 figures, 2 tables, accepted for publication in ApJ
Two early-stage inverse power-law dyamics in nonlinear complex systems far-from equilibrium
Creators: name: Bhattacharya, Somnath
name: Sen, Asok K.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We consider the dynamics of the charge carriers in a tunneling-enhanced percolation network, named as a Random Resistor cum Tunneling-bond Network (RRTN), where we allow tunneling in the gap between two randomly thrown nearest neighbour metallic bonds only. Our earlier studies involve the dc and the ac nonlinear response, the percolative aspects, dielectric breakdown, low-temperature variable range hopping (VRH) conduction, etc. in the RRTN. Here we study the non-equilibrium dynamics of the carriers. With two far-from- equilibrium, initial inverse power-law relaxations extending over several decades, the dynamics has a lot of similarities with a wide variety of naturally occuring avalance-like, run-away phenomena in driven, disordered systems with statistically correlated randomness. In the power-law regime, the RRTN violates the Boltzmann's (or Debye) relaxation time approximation strongly. Beyond this regime, the response relaxes exponentially fast (acquires one time-scale) to a steady-state, and thus the relaxation approximation becomes exact.
description: RevTex4, 6 pages, 4 figures
7-Branes and Higher Kaluza-Klein Branes
Creators: name: Lozano-Tellechea, Ernesto
name: Ortin, Tomas
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present and study a new chain of 10-d T duality related solutions and their 11-d parents whose existence had been predicted in the literature based in U duality requirements in 4 d. The first link is the S dual of the D7-brane. The next link has 6 spatial worldvolume dimensions, it is charged w.r.t. the RR 7-form but depends only on 2 transverse dimensions since the third has to be compactified in a circle and is isometric and hence is similar in this respect to the KK monopole. The next link has 5 spatial worldvolume dimensions, it is charged w.r.t. the RR 6-form but depends only on 2 transverse dimensions since the 3rd and 4th have to be compactified in circles and are isometric and so on. All these solutions are identical when reduced over the p spatial worldvolume dimensions and preserve a 1/2 on the supersymmetries. Their masses depend on the square of the radii of the isometric directions, just as for the KK monopole. We give a general map of these branes and their duality relations and show how they must appear in the supersymmetry algebra.
description: A few misprints corrected
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00378
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00378, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00378, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Direct Observation of the Fourth Star in the Zeta Cancri System
Creators: name: Hutchings, J. B.
name: Griffin, R. F.
name: Menard, F.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Direct imaging of the zeta Cnc system has resolved the fourth star in the system, which is in orbit around zeta Cnc C. The presence of the fourth star has been inferred for many years from irregularities in the motion of star C, and recently from C's spectroscopic orbit. However, its mass is close to that of C, making its non-detection puzzling. Observing at wavelengths of 1.2, 1.7, and 2.2 microns with the adaptive-optics system of the CFHT, we have obtained images which very clearly reveal star D and show it to have the color of an M2 star. Its brightness is consonant with its being two M stars, which are not resolved in our observations but are likely to be in a short-period orbit, thereby accounting for the large mass and the difficulty of detection at optical wavelengths, where the magnitude difference is much larger. The positions and colors of all four stars in the system are reported and are consistent with the most recent astrometric observations.
description: 7 pages including 3 tables, 1 figure; To appear in PASP
The relativistic impulse approximation for the exclusive electrodisintegration of the deuteron
Creators: name: Bondarenko, S. G.
name: Burov, V. V.
name: Rogochaya, E. P.
name: Goy, A. A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The electrodisintegration of the deuteron in the frame of the Bethe-Salpeter approach with a separable kernel of the nucleon-nucleon interaction is considered. This conception keeps the covariance of a description of the process. A comparison of relativistic and nonrelativistic calculations is presented. The factorization of the cross section of the reaction in the impulse approximation is obtained by analytical calculations. It is shown that the photon-neutron interaction plays an important role.
description: 31 pages, 14 figures, 1 table
Novel multi-functional europium-doped gadolinium oxide nanoparticle aerosols facilitate the study of deposition in the developing rat lung
Creators: name: Das, Gautom Kumar
name: Anderson, Donald S.
name: Wallis, Chris D.
name: Carratt, Sarah A.
name: Kennedy, Ian M.
name: Winkle, Laura S. Van
Publisher: name: Royal Society Of Chemistry
Year: 2016

description: Ambient ultrafine particulate matter (UPM), less than 100 nm in size, has been linked to the development and exacerbation of pulmonary diseases. Age differences in susceptibility to UPM may be due to a difference in delivered dose as well as age-dependent differences in lung biology and clearance. In this study, we developed and characterized aerosol exposures to novel metal oxide nanoparticles containing lanthanides to study particle deposition in the developing postnatal rat lung. Neonatal, juvenile and adult rats (1, 3 and 12 weeks old) were nose only exposed to 380 μg m⁻³ of ∼30 nm europium doped gadolinium oxide nanoparticles (Gd₂O₃:Eu³⁺) for 1 h. The deposited dose in the nose, extrapulmonary airways and lungs was determined using inductively-coupled plasma mass spectroscopy. The dose of deposited particles was significantly greater in the juvenile rats at 2.22 ng per g body weight compared to 1.47 ng per g and 0.097 ng per g for the adult and neonate rats, respectively. Toxicity was investigated in bronchoalveolar lavage fluid (BALF) by quantifying recovered cell types, and measuring lactate dehydrogenase activity and total protein. The toxicity data suggests that the lanthanide particles were not acutely toxic or inflammatory with no increase in neutrophils or lactate dehydrogenase activity at any age. Juvenile and adult rats had the same mass of deposited NPs per gram of lung tissue, while neonatal rats had significantly less NPs deposited per gram of lung tissue. The current study demonstrates the utility of novel lanthanide-based nanoparticles to study inhaled particle deposition in vivo and has important implications for nanoparticles delivery to the developing lung either as therapies or as a portion of particulate matter air pollution.
COMMODITY PRICE IMPACTS ON THE EMERGING ECONOMY OF BRAZIL
Creators: name: Hunt, Crosby A.
Publisher: name: Zenodo
Year: 2021
Subjects: Brazil
SVAR
commodity
exchange rate
macroeconomics
REAL

description: There have been many multi-national studies on the role of commodity prices on emerging economies. There is less research on specific index price impacts on domestic growth, exchange rates, and price fluctuation within a commodity dependent national economy. When prices change, the global commodity marketplace has a significant impact on those nations, specifically stability and growth in the domestic economy. The country of Brazil responded to several internal and external events, particularly the years following the Argentinian crisis of 2002, global financial crisis of 2008, and regional political unrest in 2014. The impact of these was a part of a larger economic response in Brazil that incorporated both monetary and fiscal policy that the Brazilian Central Bank used to respond to financial crises. I use a Structural Vector Auto Regressive (SVAR) model to estimate the shocks of commodity prices on growth and exchange rate with both the US and China. Likewise, this study analyzes the role of monetary policy on the domestic economy. This approach depends on and uses the robustness tests to specify impulse response functions and structural variance decompositions to estimate the relationship amongst the variables in both the short run and long run. The results produced reflect similar trends as previous research, showing that commodity price shocks along with Brazil Central Bank policy impact money supply, sustainable growth, and exchange rates with trading partner currencies.
Variable Range Hopping Conduction in Complex Systems and a Percolation Model with Tunneling
Creators: name: Sen, Asok K.
name: Bhattacharya, Somnath
Publisher: name: arXiv
Year: 2005
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: For the low-temperature electrical conductance of a disordered {\it quantum insulator} in $d$-dimensions, Mott \cite{mott} had proposed his Variable Range Hopping (VRH) formula, $G(T) = G_0 {\rm exp}[-(T_0/T)^γ]$, where $G_0$ is a material constant and $T_0$ is a characteristic temperature scale. For disordered but non-interacting carrier charges, Mott had found that $γ= 1/(d+1)$ in $d$-dimensions. Later on, Efros and Shkolvskii \cite{esh} found that for a pure ({\it i.e.}, disorder-free) {\it quantum insulator} with interacting charges, $γ=1/2$, {\it independent of d}. Recent experiments indicate that $γ$ is either (i) larger than any of the above predictions; and, (ii) more intriguingly, it seems to be a function of $p$, the dopant concentration. We investigate this issue with a {\it semi-classical} or {\it semi-quantum} RRTN ({\it Random Resistor cum Tunneling-bond Network}) model, developed by us in the 1990's. These macroscopic {\it granular/ percolative composites} are built up from randomly placed meso- or nanoscopic coarse-grained clusters, with two phenomenological functions for the temperature-dependence of the metallic and the semi-conducting bonds. We find that our RRTN model (in 2D, for simplicity) also captures this continuous change of $γ$ with $p$, satisfactorily.
description: RevTex4, 4 pages, 5 figures, Presented in conference named "Continuum Models and Discrete Systems" (CMDS10) held in Shoresh, Israel, during 30 June - 04 July, 2003
Ultra-long magnetic nanochains for highly efficient arsenic removal from water
Creators: name: Das, Gautom Kumar
name: Bonifacio, Cecile S.
name: De Rojas, Julius
name: Liu, Kai
name: Van Benthem, Klaus
name: Kennedy, Ian M.
Publisher: name: Royal Society Of Chemistry
Year: 2014

description: The contamination of drinking water with naturally occurring arsenic is a global health threat. Filters that are packed with adsorbent media with a high affinity for arsenic have been used to de-contaminate water—generally iron or aluminium oxides are favored materials. Recently, nanoparticles have been introduced as adsorbent media due to their superior efficiency compared to their bulk counter-parts. An efficient nanoadsorbent should ideally possess high surface area, be easy to synthesize, and most importantly offer a high arsenic removal capacity. Achieving all the key features in a single step synthesis is an engineering challenge. We have successfully engineered such a material in the form of nanochains synthesized via a one step flame synthesis. The ultra-long γ-Fe₂O₃ nanochains possess high surface area (151.12 m² g⁻¹), large saturation magnetization (77.1 emu g⁻¹) that aids in their gas phase self-assembly into long chains in an external magnetic field, along with an extraordinary arsenic removal capacity (162 mg g⁻¹). A filter made with this material exhibited a relatively low-pressure drop and very little break-through of the iron oxide across the filter.
Spectral asymmetries in the resonance fluorescence of two-level systems under pulsed excitation
Creators: name: Gustin, Chris
name: Manson, Ross
name: Hughes, Stephen
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present an open-system master equation study of the coherent and incoherent resonance fluorescence spectrum from a two-level quantum system under coherent pulsed excitation. Several pronounced features which differ from the fluorescence under a constant drive are highlighted, including a multi-peak structure and a pronounced off-resonant spectral asymmetry, in stark contrast to the conventional symmetrical Mollow triplet. We also study semiconductor quantum dot systems using a polaron master equation, and show how the key features of dynamic resonance fluorescence change with electron--acoustic-phonon coupling.
Additional file 1 of Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe
Creators: name: Xiao, Runsha
name: Zheng, Fan
name: Kang, Kuo
name: Xiao, Lei
name: Bi, Anyao
name: Chen, Yiting
name: Zhou, Qi
name: Feng, Xueping
name: Chen, Zhikang
name: Yin, Hao
name: Wang, Wei
name: Chen, Zihua
name: Cheng, Xiaomiao
name: Zeng, Wenbin
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Scheme S1. The synthesis route of HTI. Fig. S1. 1H NMR spectrum of HTI in Methanol-d4. Fig. S2. 13C NMR spectrum of HTI in Methanol-d4. Fig. S3. HRMS spectrum of HTI. Fig. S4. Absorption spectra of HTI (10 μM) in methanol or glycerin. λex = 500 nm. Fig. S5. Fluorescence intensity of HTI (10 μM) in PBS buffer solutions with different pH values.λex= 500 nm. Fig. S6. UV−vis absorption spectra of ABDA (50 μM) with (A) or without (B) Ce6 (10 μM) upon various periods of white light irradiation (60 mW cm−2). Fig. S7. Cytotoxicity test for HTI in SW-620 cells or HCT-116 cells or NCM-460 cells. Fig. S8. (A) Merged channel of HCT-116 cells incubated with HTI and MitoTracker-Green. (B) Fluorescence intensities of HTI and MitoTracker-green on the white arrows in A. (C) Merged channel of HCT-116 cells incubated with HTI and LysoTracker-Green. (D) Fluorescence intensities of HTI and LysoTracker-Green on the white arrows in C. Fig. S9. Fluorescence emission spectra of HTI (10 μM) coexisting with nystatin (10 μM) or monensin (10 μM) in methanol. λex = 500 nm.
Mavorixafor: First Approval
Creators: name: Hoy, Sheridan M.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description: Declarations

Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Sheridan M. Hoy is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable

Additional information about this Adis Drug Review can be found here.

Abstract
Mavorixafor (XOLREMDI™) is an oral, selective C-X-C chemokine receptor 4 (CXCR4) antagonist developed by X4 Pharmaceuticals that blocks the binding of C-X-C chemokine ligand 12 (also known as stromal derived factor-1) to CXCR4. In April 2024, it became the first therapy to be approved for WHIM syndrome (named by an acronym for its observed characteristics of Warts, Hypogammaglobulinaemia, Infections and Myelokathexis) in the USA, where it is indicated for use in patients aged ≥ 12 years with WHIM syndrome to increase the number of circulating mature neutrophils and lymphocytes. Clinical development of mavorixafor is ongoing for chronic neutropenic disorders. This article summarizes the milestones in the development of mavorixafor leading to this first approval for use in patients aged ≥ 12 years with WHIM syndrome to increase the number of circulating mature neutrophils and lymphocytes
© Springer Nature Switzerland AG 2024
NaGdF₄:Eu³⁺ Nanoparticles for Enhanced X-ray Excited Optical Imaging
Creators: name: Sudheendra, L.
name: Das, Gautom Kumar
name: Li, Changqing
name: Stark, Daniel
name: Cena, Jake
name: Cherry, Simon
name: Kennedy, Ian M.
Publisher: name: ACS
Year: 2014

description: X-ray luminescent nanoparticles (NPs), including lanthanide fluorides, have been evaluated for application to deep tissue in vivo molecular imaging using optical tomography. A combination of high material density, higher atomic number and efficient NIR luminescence from compatible lanthanide dopant ions indicates that particles that consist of ALnF₄ (A = alkaline, Ln = lanthanide element) may offer a very attractive class of materials for high resolution, deep tissue imaging with X-ray excitation. NaGdF₄:Eu³⁺ NPs produced an X-ray excited luminescence that was among the most efficient of nanomaterials that have been studied thus far. We have systematically studied factors such as (a) the crystal structure that changes the lattice environment of the doped Eu³⁺ ions within the unit cell; and extrinsic factors such as (b) a gold coating (with attendant biocompatibility) that couples to a plasmonic excitation, and (c) changes in the NPs surface properties via changes in the pH of the suspending medium—all with a significant impact on the X-ray excited luminescence of NaGdF₄:Eu³⁺NPs. The luminescence from an optimally doped hexagonal phase NaGdF₄:Eu³⁺ nanoparticle was 25% more intense compared to that of a cubic structure. We observed evidence of plasmonic reabsorption of midwavelength emission by a gold coating on hexagonal NaGdF₄:Eu³⁺ NPs; fortunately, the NaGdF₄:Eu³⁺ @Au core–shell NPs retained the efficient 5D₀→7F₄ NIR (692 nm) luminescence. The NaGdF₄:Eu³⁺ NPs exhibited sensitivity to the ambient pH when excited by X-rays, an effect not seen with UV excitation. The sensitivity to the local environment can be understood in terms of the sensitivity of the excitons that are generated by the high energy X-rays (and not by UV photons) to crystal structure and to the surface state of the particles.
Spanish Clinical Embeddings (SCE)
Creators: name: Almagro, M.
name: Martínez, R.
name: Fresno, V.
name: Montalvo, S.
Publisher: name: Zenodo
Year: 2021

description: Two versions of word embeddings have been published: SCE and SCE-SUC. Spanish Clinical Embeddings (SCE) has been trained on over 315 million clinical tokens from Electronic Health Records (EHRs) and PhD medical theses. SCE-SUC has been trained on the above sources but initialising with vectors trained on Spanish Unannotated corpora (https://github.com/dccuchile/spanish-word-embeddings). Both embeddings produce a word vector space with more than 420 thousand vectors. The evaluation of the translated data sets UMNSRS-sim, UMNSRS-rel, and MayoSRS yields the following pearson values: SCE: 0.59, 0.51, and 0.54. SCE-SUC: 0.58, 0.52, and 0.52.
Thermoelectric transport properties in graphene connected molecular junctions
Creators: name: Rodriguez, S. T.
name: Grosu, I.
name: Crisan, M.
name: Tifrea, I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the electronic contribution to the main thermoelectric properties of a molecular junction consisting of a single quantum dot coupled to graphene external leads. The system electrical conductivity (G), Seebeck coefficient ($S$), and the thermal conductivity ($κ$), are numerically calculated based on a Green's function formalism that includes contributions up to the Hartree-Fock level. We consider the system leads to be made either of pure or gapped-graphene. To describe the free electrons in the gapped-graphene electrodes we used two possible scenarios, the massive gap scenario, and the massless gap scenario, respectively. In all cases, the Fano effect is responsible for a strong violation of the Wiedemann-Franz law and we found a substantial increase of the system figure of merit $ZT$ due to a drastic reduction of the system thermal coefficient. In the case of gapped-graphene electrodes, the system figure of merit presents a maximum at an optimal value of the energy gap of the order of $Δ/D\sim$ 0.002 (massive gap scenario) and $Δ/D\sim$ 0.0026 (massless gap scenario). Additionally, for all cases, the system figure of merit is temperature dependent.
description: 7 pages, 6 figures
Heterogeneous nanostructures for plasmonic interaction with luminescence and quantitative surface-enhanced Raman spectroscopy
Creators: name: Das, Gautom Kumar
name: Sudheendra, L.
name: Kennedy, Ian M.
Publisher: name: SPIE
Year: 2014

description: SPIE BiOS, 2014, San Francisco, California, United States
description: NIR-to-visible up-conversion nanomaterials have been investigated in many promising applications including nextgeneration displays, solar cells, and biological labels. When doped with different trivalent lanthanide ions, NaYF₄ nanoparticles can produce up-converted emission from visible to infra-red wavelengths. However, the quantum yield of this class of materials is low. Noble metals in the vicinity of the phosphor can increase the phosphorescence by local field enhancement due to plasmonic resonances, and by modification of the radiative rate of the phosphor. Most previous studies have investigated the phenomenon by placing nanophosphors onto a metal substrate, or by fabrication of nano structures with spacers such as polymers, dielectric materials (silica). By contrast, we have studied the interaction between the luminescence and the surface plasmon using a core-shell type nanostructure where a uniform shell of silver is shown to grown on doped-NaYF₄ nanophosphors by Ostwald ripening. We further demonstrate the proximity effect of metal-enhanced luminescence by exciting an undoped NaYF₄ shell. The result shows a significant synergistic enhancement of up-conversion luminescence due to the active shell as spacer layer. In addition, we have shown this novel nanostructure may be useful in surface-enhanced Raman spectroscopy (SERS).
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Cart. 167 (11 H 67), f. 0085v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0085v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0085v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 4 of Safety evaluation on low-molecular-weight hydroxyethyl starch for volume expansion therapy in pediatric patients: a meta-analysis of randomized controlled trials
Creators: name: Li, Lixia
name: Li, Yongyang
name: Xu, Xiaoxing
name: Xu, Bo
name: Ren, Rongrong
name: Liu, Yan
name: Zhang, Jian
name: He, Bin
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: The funnel plot of the effect on coagulation and bleeding. a) Activated partial thromboplastin time (APTT). b) Platelet count. c) Blood loss. SE,standard error; MD,mean difference.
Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging
Creators: name: Sudheendra, L.
name: Das, Gautom Kumar
name: Li, C.
name: Cherry, Simon R.
name: Kennedy, Ian M.
Publisher: name: SPIE
Year: 2013

description: SPIE BiOS, 2013, San Francisco, California, United States.
description: Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd³⁺ and Eu³⁺compositions in lanthanide fluorides to optimize the emission from Eu³⁺ upon X-ray excitation. The optimum concentration of Eu³⁺ that produced the most intense emission in NaGdF₄ was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce³⁺) in NaGdF₄:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF₄:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
BPS Bound States Of D0-D6 And D0-D8 Systems In A B-Field
Creators: name: Witten, Edward
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The D0-D6 system, which is not supersymmetric in the absence of a Neveu-Schwarz B-field, becomes supersymmetric if a suitable constant B-field is turned on. On one side of the supersymmetric locus, this system has a BPS bound state, and on the other side it does not. After compactification on T^6, this gives a simple example in which the number of 1/8 BPS states jumps as the moduli of the compactification are changed. The D0-D8 system in a B-field has two different supersymmetric loci, only one of which is continuously connected to the familiar supersymmetric D0-D8 system without a B-field. In a certain range, the D0-D8 system also has a BPS bound state. In the limit in which the B-field goes to infinity, supersymmetric D0-D6 and D0-D8 systems and their bound states can be studied using noncommutative Yang-Mills theory.
description: 16 pp
Logarithmic de Rham comparison for open rigid spaces
Creators: name: Li, Shizhang
name: Pan, Xuanyu
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Geometry (math.AG)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 14G22

description: In this note, we prove the logarithmic $p$-adic comparison theorem for open rigid analytic varieties. We prove that a smooth rigid analytic variety with a strict simple normal crossing divisor is locally $K(π,1)$ (in a certain sense) with respect to $\mathbb{F}_p$-local systems and ramified coverings along the divisor. We follow Scholze's method to produce a pro-version of the Faltings site and use this site to prove a primitive comparison theorem in our setting. After introducing period sheaves in our setting, we prove aforesaid comparison theorem.
description: Add references. 39 pages, comments welcome v2: final version, 40 pages, comments still welcome
“Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy
Creators: name: Zhang, Yan
name: Das, Gautom Kumar
name: Vijayaragavan, Vimalan
name: Xu, Qing Chi
name: Padmanabhan, Parasuraman
name: Bhakoo, Kishore K.
name: Selvan, Subramanian Tamil
name: Tan, Timothy Thatt Yang
Publisher: name: Royal Society Of Chemistry
Year: 2014

description: The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF₄:Yb³⁺/NaGdF₄:Yb³⁺,Er³⁺, which is able to circumvent the up-converting poisoning effect of Dy³⁺ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T₂-weighted MR contrast but also tunable bright and T₁-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent.
The critical window for the classical Ramsey-Turán problem
Creators: name: Fox, Jacob
name: Po-Shen  Loh
name: Yufei  Zhang
Publisher: name: Carnegie Mellon University
Year: 2014
Subjects: subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: The first application of Szemerédi’s powerful regularity method was the following celebrated Ramsey-Turán result proved by Szemerédi in 1972: any K 4-free graph on n vertices with independence number o(n) has at most (18+o(1))n2 edges. Four years later, Bollobás and Erdős gave a surprising geometric construction, utilizing the isoperimetric inequality for the high dimensional sphere, of a K 4-free graph on n vertices with independence number o(n) and (18−o(1))n2 edges. Starting with Bollobás and Erdős in 1976, several problems have been asked on estimating the minimum possible independence number in the critical window, when the number of edges is about n 2/8. These problems have received considerable attention and remained one of the main open problems in this area. In this paper, we give nearly best-possible bounds, solving the various open problems concerning this critical window.
Novel lanthanide-labeled metal oxide nanoparticles improve the measurement of in vivo clearance and translocation
Creators: name: Abid, Aamir D.
name: Anderson, Donald S.
name: Das, Gautom Kumar
name: Winkle, Laura S. Van
name: Kennedy, Ian M.
Publisher: name: Springer
Year: 2013

description: The deposition, clearance and translocation of europium-doped gadolinium oxide nanoparticles in a mouse lung were investigated experimentally. Nanoparticles were synthesized by spray flame pyrolysis. The particle size, crystallinity and surface properties were characterized. Following instillation, the concentrations of particles in organs were determined with inductively coupled plasma mass spectrometry. The protein corona coating the nanoparticles was found to be similar to the coating on more environmentally relevant nanoparticles such as iron oxide. Measurements of the solubility of the nanoparticles in surrogates of biological fluids indicated very little propensity for dissolution, and the elemental ratio of particle constituents did not change, adding further support to the contention that intact nanoparticles were measured. The particles were intratracheally instilled into the mouse lung. After 24 hours, the target organs were harvested, acid digested and the nanoparticle mass in each organ was measured by inductively coupled plasma mass spectrometry (ICP-MS). The nanoparticles were detected in all the studied organs at low ppb levels; 59% of the particles remained in the lung. A significant amount of particles was also detected in the feces, suggesting fast clearance mechanisms. The nanoparticle system used in this work is highly suitable for quantitatively determining deposition, transport and clearance of nanoparticles from the lung, providing a quantified measure of delivered dose.
Testing superscaling predictions in electroweak excitations of nuclei
Creators: name: Martini, M.
name: Có, G.
name: Anguiano, M.
name: Lallena, A. M.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Superscaling analysis of electroweak nuclear response functions is done for momentum transfer values from 300 to 700 MeV/c. Some effects, absent in the Relativistic Fermi Gas model, where the superscaling holds by construction, are considered. From the responses calculated for the 12C, 16O and 40Ca nuclei, we have extracted a theoretical universal superscaling function similar to that obtained from the experimental responses. Theoretical and empirical universal scaling functions have been used to calculate electron and neutrino cross sections. These cross sections have been compared with those obtained with a complete calculation and, for the electron scattering case, with the experimental data.
description: 9 pages, 3 figures. To appear in the Proceedings of "XI Conference on Problems in Theoretical Nuclear Physics", Cortona, Italy, 11-14 October 2006
Sublethal Effects of CuO Nanoparticles on Mozambique Tilapia (Oreochromis mossambicus) Are Modulated by Environmental Salinity
Creators: name: Villarreal, Fernando D.
name: Das, Gautom Kumar
name: Abid, Aamir
name: Kennedy, Ian M.
name: Kültz, Dietmar
Publisher: name: Plos One
Year: 2014

description: The increasing use of manufactured nanoparticles (NP) in different applications has triggered the need to understand their putative ecotoxicological effects in the environment. Copper oxide nanoparticles (CuO NP) are toxic, and induce oxidative stress and other pathophysiological conditions. The unique properties of NP can change depending on the characteristics of the media they are suspended in, altering the impact on their toxicity to aquatic organisms in different environments. Here, Mozambique tilapia (O. mossambicus) were exposed to flame synthesized CuO NP (0.5 and 5 mg·L⁻¹) in two environmental contexts: (a) constant freshwater (FW) and (b) stepwise increase in environmental salinity (SW). Sublethal effects of CuO NP were monitored and used to dermine exposure endpoints. Fish exposed to 5 mg·L⁻¹ CuO in SW showed an opercular ventilation rate increase, whereas fish exposed to 5 mg·L⁻¹ in FW showed a milder response. Different effects of CuO NP on antioxidant enzyme activities, accumulation of transcripts for metal-responsive genes, GSH∶GSSG ratio, and Cu content in fish gill and liver also demonstrate that additive osmotic stress modulates CuO NP toxicity. We conclude that the toxicity of CuO NP depends on the particular environmental context and that salinity is an important factor for modulating NP toxicity in fish.
Jacob's Ladder: Prime numbers in 2d
Creators: name: Fraile, Alberto
name: Martinez, Roberto
name: Fernandez, Daniel
Publisher: name: arXiv
Year: 2018
Subjects: subject: History and Overview (math.HO)
subject: FOS: Mathematics

description: Prime numbers are one of the most intriguing figures in mathematics. Despite centuries of research, many questions remain still unsolved. In recent years, computer simulations are playing a fundamental role in the study of an immense variety of problems. In this work, we present a simple representation of prime numbers in two dimensions that allows us to formulate a number of conjectures that may lead to important avenues in the field of research on prime numbers. In particular, although the zeroes in our representation grow in a somewhat erratic, hardly predictable way, the gaps between them present a remarkable and intriguing property: a clear exponential decay in the frequency of gaps vs gap size. The smaller the gaps, the more frequently they appear. Additionally, the sequence of zeroes, despite being non-consecutive numbers, contains a number of primes approximately equal to n/log(n) , being n the number of terms in the sequence.
description: 17 pages, 12 figures. v2: Accuracy improved, new results included and references added. v3: Slight clarifications, matches version accepted by journal