cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mid-infrared frequency combs and staggered spectral patterns in $χ^{(2)}$ microresonators
Creators: name: Amiune, Nicolas
name: Fan, Zhiwei
name: Pankratov, Vladislav V.
name: Puzyrev, Danila N.
name: Skryabin, Dmitry V.
name: Zawilski, Kevin T.
name: Schunemann, Peter G.
name: Breunig, Ingo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The potential of frequency comb spectroscopy has aroused great interest in generating mid-infrared frequency combs in the integrated photonic setting. However, despite remarkable progress in microresonators and quantum cascade lasers, the availability of suitable mid-IR comb sources remains scarce. Here, we present a new approach for the generation of mid-IR microcombs through cascaded three-wave-mixing. By pumping a CdSiP$_2$ microresonator at 1.55 $μ$m wavelength with a low power continuous wave laser, we generate $χ^{(2)}$ frequency combs at 3.1 $μ$m wavelength, with a span of about 30 nm. We observe ordinary combs states with a line spacing of the free spectral range of the resonator, and combs where the sideband numbers around the pump and half-harmonic alternate, forming staggered patterns of spectral lines. Our scheme for mid-IR microcomb generation is compatible with integrated telecom lasers. Therefore, it has the potential to be used as a simple and fully integrated mid-IR comb source, relying on only one single material.
An investigation into the role of Ap4A and Ap4Ns in the inhibition of the initiation phase of DNA replication
Creators: name: Ferguson, Freya
Publisher: name: Lancaster University
Year: 2023

description: Precise DNA replication is essential for the maintenance of a healthy genome. Although DNA replication has a very high fidelity, mutations can be introduced during this process, and the likelihood of mutation increases when a cell is under stress. Therefore, several signalling mechanisms exist, such as the ATM and ATR-dependent signalling in the DNA damage response, which stall DNA replication and promote the repair of damage. Diadenosine tetraphosphate (Ap4A) levels increase in response to cell stress, where it inhibits the initiation phase of DNA replication at micromolar levels. However, the mechanistic basis for its inhibitory activity has not yet been determined. In addition, there are other dinucleoside tetraphosphates (Ap4Ns) that have extracellular signalling roles, yet their synthesis and intracellular function have not been established. Here we present evidence suggesting that Ap4Ns can be synthesised by UBE1 in a biologically relevant manner. We have developed a technique for the extraction and detection of Ap4A, Ap4C, Ap4G and Ap4U by triple quadrupole mass spectrometry in extracts from a mammalian KBM7 cell line with a disrupted Nudt2 gene (NuKO). Furthermore, we have applied this technique to investigate the effect of DNA damaging agents and DNA stressing agents on Ap4N levels in NuKO cells. Finally, the inhibitory effect of each Ap4N in a cell-free DNA replication system containing late G1 nuclei and S-phase cytosolic extract demonstrates that Ap4Ns have the capacity to inhibit the initiation of DNA replication. Further analysis suggests that Ap4Ns reduce initiation by reducing the chromatin localisation of the key replication proteins Mcm2 and PCNA. Together, these data suggest that both Ap4A and Ap4Ns may regulate the DNA replication process and that they could represent an additional regulatory mechanism to prevent untimely entry into S-phase during genotoxic stress.
ELT and Social Media: Integrating TikTok into Class Practice
Creators: name: Canani, Marco
name: Zulli, Tania
Publisher: name: mediAzioni
Year: 2022

description: This paper analyses the impact of social media (SM) applications on English Language Teaching (ELT) by focusing on their integration into classroom practice. By drawing on a survey conducted among the students of the “G. d’Annunzio” University of Chieti-Pescara, two accounts recently set up on TikTok – the SM app based on the creation and sharing of short videos – are considered as tools to improve class practice for the teaching of English vocabulary, pronunciation, and idioms. The quantitative analysis adopted in the survey provides the notional ground for two sample lesson plans in which the integration of these TikTok videos into a Presentation-Practice-Production (PPP) approach is proposed. The motivation aroused by the short videos and the students’ perceived usefulness of these profiles prove instrumental in devising teaching strategies that may be successfully implemented in the EFL/ESL classroom.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
KMC 2: Fast and resource-frugal $k$-mer counting
Creators: name: Deorowicz, Sebastian
name: Kokot, Marek
name: Grabowski, Szymon
name: Debudaj-Grabysz, Agnieszka
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Genomics (q-bio.GN)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Motivation: Building the histogram of occurrences of every $k$-symbol long substring of nucleotide data is a standard step in many bioinformatics applications, known under the name of $k$-mer counting. Its applications include developing de Bruijn graph genome assemblers, fast multiple sequence alignment and repeat detection. The tremendous amounts of NGS data require fast algorithms for $k$-mer counting, preferably using moderate amounts of memory. Results: We present a novel method for $k$-mer counting, on large datasets at least twice faster than the strongest competitors (Jellyfish~2, KMC~1), using about 12\,GB (or less) of RAM memory. Our disk-based method bears some resemblance to MSPKmerCounter, yet replacing the original minimizers with signatures (a carefully selected subset of all minimizers) and using $(k, x)$-mers allows to significantly reduce the I/O, and a highly parallel overall architecture allows to achieve unprecedented processing speeds. For example, KMC~2 allows to count the 28-mers of a human reads collection with 44-fold coverage (106\,GB of compressed size) in about 20 minutes, on a 6-core Intel i7 PC with an SSD. Availability: KMC~2 is freely available at http://sun.aei.polsl.pl/kmc. Contact: sebastian.deorowicz@polsl.pl
title: Preoperative senological review: interests and limits of the preoperative radiological validation in the presence of the patient.
Creators: name: Flory, Violaine
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Image verification
subject: Cancer
subject: Surgery
subject: Observer performance
subject: Biopsy
subject: Ultrasound
subject: MR
subject: Mammography
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: In France, breast cancer mass screening is based on a reviewing process : any BIRADS 1 or 2 mammogram is reviewed by a breast specialist radiologist to assess the absence of suspicious lesion, with additional cancer detection rate of 7%. In our...
Borelian subgroups of simple Lie groups
Creators: name: de Saxcé, Nicolas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: We prove that in a simple real Lie group, there is no Borel measurable dense subgroup of intermediate Hausdorff dimension.
description: 26 pages, no figure
Dall’illecito efficiente ai punitive damages. Il risarcimento del danno da illecito antitrust
Creators: name: Ricciardi, Angela
Publisher: name: Universita degli studi di Salerno
Year: 2018
Subjects: subject: IUS/04 DIRITTO COMMERCIALE
subject: Illecito antitrust
subject: Profitto illecito
subject: Punitive damages

description: 2016 - 2017
description: The research originates from problems mentioned during the debate on the “efficient tort”. The term refers to the category of those actions, normally characterised by high levels of infringement, likely to produce a profit for the damaging part much greater than the loss incurred by the injured party. Therefore, the attention focused particularly on the most appropriate remedy for the identification of the right classification of this surplus value. Having excluded the other ways, the instrument has been found in the civil responsibility. More specifically, the research confers, to this responsibility, a sanction value, beyond the compensatory one, distancing itself from the traditional opinion. On these bases, the attention focused on the new regulation of the private enforcement in the field of “illecito antitrust”. The reference is to the latest D.Leg 19 January 2017 n. 3 intervened in the implementation of the Direcrive 2014/104 UE. This new regulation, maintaining the prohibition of overcompensation, in a field like the one in question, where the needs of deterrence are evidently revealed, exposes itself to various censures from the point of view of the constitutional legitimacy. Hence the attempt to provide a costitutionally oriented interpretation of the law in question that, hopefully, will be able to enlighten the future activity of the law and the legislator. [edited by Author]
Planar Black Holes in Holographic Axion Gravity: Islands, Page Times, and Scrambling Times
Creators: name: Mansoori, Seyed Ali Hosseini
name: Luongo, Orlando
name: Mancini, Stefano
name: Mirjalali, Mirmani
name: Rafiee, Morteza
name: Tavanfar, Alireza
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The present work investigates the entanglement entropies of the Hawking radiations, the Page times, and the scrambling times, for the eternal planar black holes in the holographic axion gravity. The solutions correspond to a new class of charged black holes, because the boundary diffeomorphism is broken due to the graviton mass induced by the axion fields in the bulk. The information theoretical aspects of these black hole solutions is determined upon applying the island rule for the entanglement entropy. Like non-extremal charged black holes, the radiation entropy grows linearly in the no-island configurations, while is saturated at late times by asymptotic values set by the Bekenstein-Hawking entropy in the island configurations, with the boundary being located slightly outside the outer horizon. In particular, for the extremal black planes of holographic axion gravity, we find that: (a) the entanglement entropy of the Hawking radiation is ill-defined at the early times when the island is absent; (b) it tends to a distinctive constant at the late times; (c) the late-time location of the island is indeed universal. Moreover, we investigate how the Page time is affected by the holographic massive gravity deformation. For neutral solutions at the small deformation parameter, and for charged solutions with almost-extremal deformation parameter, we find that the Page transition happens at earlier times.
description: 12 pages, 1 table, 3 figures, references added, accepted by PRD
title: The role of imaging features in diagnosis of hepatoblastoma
Creators: name: Anastasiou, Athanasia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Metastases
subject: Surgery
subject: Chemotherapy
subject: MR
subject: CT
subject: Paediatric
subject: Oncology
subject: Liver

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of our study is to present Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) features that contribute to the diagnosis of hepatoblastoma (HB) in children, in association to location at the...
Internal static electric and magnetic field at the copper cite in a single crystal of the electron-doped high-T$_{c}$ superconductor Pr$_{1.85}$Ce$_{0.15}$CuO$_{4-y}$
Creators: name: Wu, Guoqing
name: Zamborszky, F.
name: Reyes, A. P.
name: Kuhns, P. L.
name: Greene, R. L.
name: Clark, W. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report $^{63, 65}$Cu-NMR spectroscopy and Knight shift measurements on a single crystal of the electron-doped high-$T_{c}$ superconductor Pr$_{1.85}$Ce$_{0.15}$CuO$_{4-y}$ (PCCO) with an applied magnetic field ($H$) up to 26.42 T. A very small NQR frequency is obtained with the observation of the spectrum, which shows an extremely wide continuous distribution of it that becomes significant narrower below 20 K at $H$ $\parallel$ $c$ where the superconductivity is completely suppressed, indicating a significant change in the charge distribution at the Cu site, while the corresponding changes at $H$ $\perp$ $c$ is negligible when the superconductivity is present or not fully suppressed. The Knight shift and central linewidth are proportional to the applied magnetic field with a high anisotropy. We find that the magnitude of the internal static magnetic field at the copper is dominated by the anisotropic Cu$^{2+}$ 3$d$-orbital contributions, while its weak temperature-dependence is mainly determined by the isotropic contact hyperfine coupling to the paramagnetic Pr$^{3+}$ spins, which also gives rise to the full distribution of the internal static magnetic field at the copper for $H$ $\perp$ $c$. This internal static electric and magnetic field environment at the copper is very different from that in the hole-doped cuprates, and may provide new insight into the understanding of high-$T_{c}$ superconductivity. Other experimental techniques are needed to verify whether the observed significant narrowing of the charge distribution at the Cu site with $H$ $\parallel$ $c$ is caused by the charge ordering (CO) [E. H. da Silva Neto $et ~al.$, to be published in Science] \cite{ehdsn} or a new type of charge modulation.
description: 8 pages, 6 figures, submitted to Phys. Rev. B
Coping with untranslatability in AVT
Creators: name: Cavaliere, Flavia
Publisher: name: mediAzioni
Year: 2022

description: Many of the most penetrating thinkers over time have focused their attention on the issue of translation and highlighted how translating “may very probably be the most complex type of event yet produced in the evolution of the cosmos” (Richards 1953: 250). In the same vein, Walter Benjamin even maintained that “translations prove to be untranslatable” (Benjamin 1923 in Venuti 2004: 82). Such intricacy may basically be because translation “brings into play not only two languages but also two cultures” (Eco 2001: 62). As a consequence, the extent to which a text is (un)translatable may both depend on the socio-cultural distance between the Source and Target Languages and also on how deeply the text is rooted in its own Source Culture. Additionally, “the cultural implications for translation vary from lexical content and syntax to ideologies and modes of living in a given culture, including genre expectations/constraints” (Cavaliere 2019: 11). This explains why the problems inherent in all translations are at their most evident when translating and adapting a text for the screen. In AVT, in fact, in contrast to other static written modes of communication, the medium prevents both the audience from back-tracking in the text in order to retrieve meaning and, more importantly, the provision of a “thick translation […] that seeks with its annotations and its accompanying glosses to locate the text in a rich cultural and linguistic context” (Appiah 2004: 399). Drawing on the works of well-known translation/AVT scholars, my study will be carried out on English audio scripts of well-known films/TV series and their subtitled/dubbed Italian version (qualitative examples chosen on the basis of their untranslatability will be investigated). My analysis aims to highlight how untranslatability may variously result from differences between linguistic structures to socio-cultural motivations, from the in-built constraints of the medium to the condition of temporality in translation. One of the important functions of translation is to inform about a foreign culture (Levý 2011: 96), and in this perspective, a renewed emphasis on connections among translation, linguistics, philology, philosophy, and socio-cultural issues through easy-to-grasp examples may offer students possibly stimulating (cross)curricular initiatives, especially at advanced undergraduate and graduate levels.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
Antituberculosis, antioxidant and cytotoxicity profiles of quercetin: a systematic and cost-effective in silico and in vitro approach
Creators: name: Swain, Shasank S.
name: Rout, Sunil S.
name: Sahoo, Alaka
name: Oyedemi, Sunday O.
name: Hussain, Tahziba
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The ineffectiveness and the slowdown of newer anti-TB drug approval rates directly indicate searching for potential alternative agents. However, validation of isolated phytochemicals through hit-and-trial experiments is more expensive and time-consuming. Simultaneously, cost-effective computational tools can recognize most potential candidates at an initial stage. The present study selected seven plant-derived polyphenols, then verified anti-TB and drug-ability profiles using advanced computational tools before the experimental study. Among all, the quercetin showed a potential docking-score within −8 to −11 kcal/mol than the standard isoniazid and ofloxacin, −5 to −10 kcal/mol. Additionally, quercetin exhibited a higher drug-ability score of 0.53 than isoniazid 0.19. Further, quercetin exhibited the minimum inhibitory concentration at 6 and 8 μg/mL, while ofloxacin showed at 2 μg/mL against InhA, and katG mutated Mtb-strains, respectively. Parallelly, quercetin showed promising free-radical-scavenging activity from nitric-oxide assay at IC50 = 14.92 µg/mL, and lesser-cytotoxicity from cultured HepG2 cell lines at IC50 = 159 µg/mL, respectively.
Soft breaking of the $μ\leftrightarrow τ$ symmetry by $\mathbf{S}_{4}\otimes \mathbf{Z}_{2}$
Creators: name: García-Aguilar, J. D.
name: Ramírez, Asahel Enrique Pozas
name: Castañeda, Marlon Michael Suárez
name: Gómez-Izquierdo, Juan Carlos
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The $μ\leftrightarrow τ$ symmetry has been ruled out by its predictions on the reactor and atmospheric angles, nevertheless, a breaking of this symmetry might provide correct values. For that reason, we build a non-renormalizable lepton model where the mixings arise from the spontaneous breaking of the $\mathbf{S}_{4}\otimes \mathbf{Z}_{2}$ discrete group, subsequently the $μ\leftrightarrow τ$ symmetry is broken in the effective neutrino mass matrix, that comes from the type II see-saw mechanism. As main result, the reactor and atmospheric angles are corrected and their values are in good agreement with the experimental data for the inverted hierarchy. Furthermore, we point out a link between the atmospheric angle and reactor one. In the quark sector, under certain assumptions, the generalized Fritzsch textures shape to the quark mass matrices so that the CKM matrix values are guaranteed.
description: 19 pages, 6 figures. Minor changes, accepted in Revista Mexicana de F\'isica
title: Simultaneous cardiac, hepatic and pancreatic iron-overload quantification with 4 different software packages of T2*
Creators: name: Finetto, Giovanni
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Tissue characterisation
subject: Treatment effects
subject: MR
subject: Cardiac
subject: Abdomen
subject: Haematologic diseases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The early detection of heart, liver and pancreas iron - overload allows a better therapeutic approach to patients with diseases that cause iron accumulation, previously limited only to the liver. MRI exploits the iron - superparamagnetic effect and...
The local RG equation and chiral anomalies
Creators: name: Keren-Zur, Boaz
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We generalize the local renormalization group (RG) equation to theories with chiral anomalies. We find that a new anomaly is required by the Wess-Zumino consistency conditions. Taking into account the new anomaly, the trace of the energy momentum tensor is expressed in terms of the covariant flavor currents, instead of the consistent ones. This result is used to show that a flavor rotation induced by the RG flow can be eliminated by a choice of scheme even in the presence of chiral anomalies. As part of a general discussion of chiral anomalies in the presence of background sources, we also derive non-renormalization theorems. Finally, we introduce the $θ$ parameter as a source, and derive constraints on a perturbative running of this parameter.
A Multimodal Analysis of Gender Representations in British and Italian TV Advertisements
Creators: name: Centonze, Laura
name: Taronna, Annarita
Publisher: name: mediAzioni
Year: 2022

description: The present paper illustrates the preliminary findings of a CORECOM-funded project called “The representation of the image of women in advertising: interlinguistic and multimodal perspectives”. Its aim has been to identify, analyze and deconstruct semantic asymmetries which continue to proliferate in the field of information and communication, thus perpetrating discursive constructions of stereotyped and discriminating gender identities. Drawing on the most influential contributions to the study of language and gender (Lakoff 1975, Goffman 1979, Cameron 1995; Christie 2000, Lazar 2005, Jeffries 2007, Baker 2008, Mills 2008, 2012, Machin & Caldas-Coulthard 2016), the present research has identified possible pragmatic characterizations leading to the identification of subliminal, discriminating or degrading advertising messages which provide the audience with the image of a stereotyped woman or allusively associated, for example, with an aesthetic canon based on beauty as an absolute value. To this end, the comparison between advertising messages disseminated on the regional, national and international territory has brought out quantitative and qualitative data that have allowed us to define the extent to which the presence of gender stereotypes and sexualization of the female body are occurring in regional and national advertising in relation to some European countries. Reference has thus been made to advertisements in English in both English-speaking and non-English-speaking countries. Consequently, the results of interlinguistic and comparative research have also brought out useful data for the definition of pragma-linguistic patterns characterizing ELF (English as a Lingua Franca; Seidlhofer 2001) in advertising.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
Global Seismic Hazard Map
Creators: name: Johnson, Kendra
name: Villani, Manuela
name: Bayliss, Kirsty
name: Brooks, Christopher
name: Chandrasekhar, Sreyasvi
name: Chartier, Thomas
name: Chen, Yen-Shin
name: Garcia-Pelaez, Julio
name: Gee, Robin
name: Styron, Richard
name: Rood, Anna
name: Simionato, Michele
name: Pagani, Marco
Publisher: name: Zenodo
Year: 2023

description: The Global Earthquake Model (GEM) Global Seismic Hazard Map (version 2023.1) poster replaces the previous version (2018.1) released in December 2018. This map depicts the geographic distribution of the Peak Ground Acceleration (PGA) with a 10% probability of being exceeded in 50 years, computed for reference rock conditions (shear wave velocity, VS,30 of 760-800 m/s). The map was created by collating maps computed using national and regional probabilistic seismic hazard models developed by various institutions and projects and by GEM Foundation scientists. The OpenQuake engine, an open-source seismic hazard and risk calculation software developed principally by the GEM Foundation, was used to calculate the hazard values. A smoothing methodology was applied to homogenise hazard values along the model borders (Pagani et al., 2018). The map is based on a database of hazard models described using the OpenQuake engine data format (NRML); those models implemented initially in other software formats were converted into NRML. While translating these models, various checks were performed to test the compatibility between the original and new results computed using the OpenQuake engine. Overall the differences between the original and translated model results are small notwithstanding some diversity in modelling methodologies implemented in different hazard modelling software. The hatched areas in the map (e.g. Greenland) are currently not covered by an openly accessible hazard model. The underlying database is a dynamic framework capable of incorporating newly released open models. Due to possible model limitations, regions portrayed with low hazard may still experience potentially damaging earthquakes. The GEM Foundation plans to release future updates of this map regularly as new information becomes available. Technical details on the compilation of the hazard maps and the underlying models - including updates to model components made by GEM - are available at https:// hazard.openquake.org/.
Using OpenRefine for natural history collections data
Creators: name: Krimmel, Erica
name: Walker, Lindsay J.
Publisher: name: Zenodo
Year: 2022
Subjects: biodiversity informatics
data cleaning
natural history
biodiversity collections

description: OpenRefine (https://openrefine.org/) is a free, open source software for exploring and manipulating text data. As digitization and digital data management become increasingly important aspects of collections management, OpenRefine can be a useful tool to visualize data issues and to clean data efficiently. Its user interface is intuitive and provides an easier learning curve than programming languages like R, Python, SQL, etc. Additionally, because OpenRefine runs locally on your computer, it is ideal for use with sensitive data and/or no internet connection. This demo will show how to use OpenRefine’s faceting and clustering tools, which can help you identify and clean up similar values, as well as make bulk edits. The demo will also show how you can use OpenRefine to compare one column of data to another, including from an external webservice. The latter can be particularly useful when you need to reference an external authority–e.g., one that covers taxonomic nomenclature–to verify your specimen data, or when you need to acquire additional information based on the data you have–e.g., you have geographic coordinates and need to know county names. Abstract DOI: https://doi.org/10.5281/zenodo.6593930
Cytotoxic and antiproliferative activity of thiazole derivatives of Ochraceolide A
Creators: name: Herrera-España, Angel D.
name: Us-Martín, Jenner
name: Quintal-Novelo, Carlos
name: Mirón-López, Gumersindo
name: Quijano-Quiñones, Ramiro F.
name: Cáceres-Castillo, David
name: Graniel-Sabido, Manlio
name: Moo-Puc, Rosa E.
name: Mena-Rejón, Gonzalo J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A series of 15 novel 1,3-thiazole amide derivatives of the pentacyclic triterpene Ochraceolide A (1) was synthesized, characterized, and evaluated in vitro against three human cancer cell lines (MCF-7, MDA-MB-231 and SiHa) and a normal cell line (Vero). Synthetic derivatives were obtained by acylation of the 2-aminothiazole triterpene 2, previously reported. Remarkably, the 5-nitrofuramide derivative (2o) showed better cytotoxic and antiproliferative activity than compound 2 and the other derivatives against the three cancer cell lines with CC50 and IC50 values of 1.6–12.7 µM. Furthermore, butyramide derivative (2c) was approximately 25 times more selective than 2, as well as 3.4 times more selective than Docetaxel, against SiHa cells in the cytotoxic assay, while the phenyl amide derivatives were inactive against the three cancer cell lines.
Queering Collective Identities: A Case Study on Same-Sex Unions in the UK and in Italy
Creators: name: Santonocito, Carmen Serena
Publisher: name: mediAzioni
Year: 2022

description: This study centres on a cross-linguistic investigation of same-sex unions as articulated within speeches by British and Italian Prime Ministers. The analysis adds to the growing body of research on Queer perspectives and their incorporation into studies on gender and sexuality. It aims to bring together the multi-facetedness of Discourse, and its cross-contamination with Critical and Queer paradigms, as well as corpus-informed tools. The aim is to showcase how the hybrid incorporation of Queer and Critical Discourse-oriented perspectives makes explicit both dominant and marginalized discourses. Methodologically, this is realized through the blending of quantitative and qualitative analyses that combine Queer and Critical paradigms with corpus tools. The results uncover institutionalized heteronormativity operating to different degrees. The Queer engagement leaves open the possibility for a thoughtful reformulation which should challenge the same notion of inclusivity.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
Modeling dust growth in protoplanetary disks: The breakthrough case
Creators: name: Drazkowska, Joanna
name: Windmark, Fredrik
name: Dullemond, Cornelis P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Simple toy models are often not sufficient to cover the complexity of the dust coagulation process, and a number of numerical approaches are therefore used, among which integration of the Smoluchowski equation and various versions of Monte Carlo algorithm are the most popular. In this paper, we directly compare the Smoluchowski and Monte Carlo approaches and we find a general agreement for most of the coagulation problems. However, for the sweep-up growth driven by the "lucky" breakthrough mechanism, the methods exhibit very different resolution dependencies. With too few mass bins, the Smoluchowski algorithm tends to overestimate the growth rate and the probability of breakthrough. The Monte Carlo method is less resolution dependent in the growth timescale aspect but it tends to underestimate the breakthrough chance due to its limited dynamic mass range. We discuss the features and drawbacks of both the approaches, which may limit their astrophysical applications.
description: 7 pages, 4 figures; accepted for publication in Astronomy & Astrophysics
title: Associations between 18F-FDG-PET, DWI, and DCE parameters in patients with head and neck squamous cell carcinoma depend on tumor grading
Creators: name: Leifels, Leonard
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Head and neck
subject: Hybrid Imaging
subject: Ear / Nose / Throat
subject: MR
subject: MR-Diffusion/Perfusion
subject: PET-MR
subject: Diagnostic procedure
subject: Outcomes
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: HNSCC is the most frequent malignancy of the upperaerodigestive tract in humans (1). Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) provide the mainstay of imaging for diagnosis, staging and treatment response...
On $q$-Middle Convolution and $q$-Hypergeometric Equations
Creators: name: Arai, Yumi
name: Takemura, Kouichi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33D15, 39A13

description: The $q$-middle convolution was introduced by Sakai and Yamaguchi. In this paper, we reformulate $q$-integral transformations associated with the $q$-middle convolution. In particular, we discuss convergence of the $q$-integral transformations. As an application, we obtain $q$-integral representations of solutions to the variants of the $q$-hypergeometric equation by applying the $q$-middle convolution.
Secondary metabolites from Valeriana jatamansi with their anti-inflammatory activity
Creators: name: Tram, Le Huyen
name: Van Thong, Nguyen
name: Thuy, Le Thi
name: Anh, Nguyen Tuan
name: Minh, Nguyen Hoang
name: Minh, Tran Thi
name: Phuong, Nguyen Thi Hong
name: Ha, Tran Thu
name: Nguyen, Thi Minh Nguyet
name: Le, Duc Dat
name: Hiep, Nguyen Dinh
name: Park, Jong-Tae
name: Chinh, Truong Thi To
name: Huong, Tran Thu
name: Lee, Mina
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Valeriana jatamansi is hired as multiple remedies for treatment of insomnia, blood and circulatory disorders, asthma, dry cough, jaundice, seminal weakness, cardiac debility, and skin diseases in Vietnam. Our research discovered the phytochemical investigation of constituents from this herbal medicine resulted in the isolation of two new compounds (jatamansides A (4) and B (7)) together with 16 known ones from the whole plant. Their structures were established by using spectroscopic techniques (multinuclear and multidimensional nuclear magnetic resonance, infrared, ultraviolet–visible), mass spectrometry, hydrolysis analysis, or comparing their NMR data to those reported in the literature. In addition, all the isolates were evaluated for their inhibitory effect against TNF-α production in LPS-stimulated on RAW264.7 cells with significant inhibition.
The Role of Cognitive Linguistics in Corporate Storytelling – A Methodological Perspective
Creators: name: D'Avanzo, Stefania
Publisher: name: mediAzioni
Year: 2022

description: Corporate storytelling has been usually investigated from the perspective of both marketing studies (Brown 2006: 734) and corporate communication (Ford et al. 1995; Boje 2001; Clifton et al. 2020), which have emphasized the role played by narratives in corporate identity claims. This work is a pilot study aimed at providing a different methodological perspective applied to corporate narratives. In particular, theories from cognitive linguistics (Rosch 1978; Lakoff, 1987), previously applied to corporate mission statements (Ran et al.1997), will be explored here in corporate narratives. More specifically, cognitive categories including, among others, positive, negative and neutral positioning along with interaction processes (Glaser et al 1968) will be taken into consideration. Positioning, for instance, implies a value structure, as an organization can be positioned at either the positive or negative end of the continuum or at some neutral midpoint. From a general perspective, an identity claim that represents an organization too positively or too negatively may lack credibility to target audiences. Conversely, an identity claim that defines an organization neutrally may construct an identity that audiences consider more reliable. In brief, examples of storytelling employed by centenarian Italian companies (https://www.assocentenari.it/en/index.php) will be explored in order to analyse the ways these companies represent themselves from a cognitive perspective.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
Molecular absorption in transition region spectral lines
Creators: name: Schmit, Donald
name: Innes, Davina
name: Ayres, Thomas
name: Peter, Hardi
name: Curdt, Werner
name: Jaeggli, Sarah
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Aims: We present observations from the Interface Region Imaging Spectrograph (IRIS) of absorption features from a multitude of cool atomic and molecular lines within the profiles of Si IV transition region lines. Many of these spectral lines have not previously been detected in solar spectra. Methods: We examined spectra taken from deep exposures of plage on 12 October 2013. We observed unique absorption spectra over a magnetic element which is bright in transition region line emission and the ultraviolet continuum. We compared the absorption spectra with emission spectra that is likely related to fluorescence. Results: The absorption features require a population of sub-5000 K plasma to exist above the transition region. This peculiar stratification is an extreme deviation from the canonical structure of the chromosphere-corona boundary . The cool material is not associated with a filament or discernible coronal rain. This suggests that molecules may form in the upper solar atmosphere on small spatial scales and introduces a new complexity into our understanding of solar thermal structure. It lends credence to previous numerical studies that found evidence for elevated pockets of cool gas in the chromosphere.
description: accepted by A&A Letters
Critical Discourse Analysis and Positive Discourse Analysis – Commonalities and Differences
Creators: name: Abbamonte, Lucia
Publisher: name: mediAzioni
Year: 2022

description: This study outlines an integrated new perspective on the relationship between critical discourse analysis (CDA) and positive discourse analysis (PDA). CDA typically attempts to unveil the uses of language and semiosis in the service of power and is best known for its foci on ideologically driven discrimination (gender, ethnicity, class, and related social variables). Yet, CDA has not offered accounts of alternative forms of social organisation, nor of social subjects, other than by implication (Kress 1996). Concisely, ‘critical’ in CDA does not equate to ‘neutral critical thinking’, but to negative criticism of the power/language relationship. A different orientation is provided, among others, by Kress (2000) and Martin (2004). Martin’s perspective on “language and semiosis […is] oriented not so much to deconstruction as to constructive social action, through PDA [2004:180-181]”. Other instantiations of PDA, where the potential of linguistic and discourse analysis for facilitating positive intervention in social issues is considered, can be found in Macgilchrist (2007), Bartlett (2012) and Rogers (2017). More specifically, the former investigated strategies for propelling marginal discourses into the mainstream news media, while central notions in Bartlett’s and Rogers’s vision are to give voice and access to dominant discourses to less privileged, racialised social groups, and then to re-shape such discourses. Largely, topic selection makes the major difference between CDA and PDA: by selecting only discriminatory discourses to be deconstructed, there is no scope for positive critical thinking, whereas, from a PDA orientation, new transformative meanings can emerge.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
Ecolinguistics and Positive Discourse Analysis: Convergent Pathways
Creators: name: Ponton, Douglas Mark
Publisher: name: mediAzioni
Year: 2022

description: This paper explores connections between Ecolinguistics and Positive Discourse Analysis, focusing on an eco-friendly farm in Norfolk which features in a long-running BBC programme, ‘the Countryside Hour’. Both ecolinguistics and positive discourse analysis, as relatively new disciplines, stand in some need of definition, especially regarding their relationship with the more consolidated paradigm of CDA which, of course, is itself not characterised by general agreement on methodological matters (Flowerdew 2008, Stibbe 2017). This study applies some of the notions found in the practical toolkit of CDA such as framing, presupposition, metaphor analysis, pragmatics and relevance theory and explores their functioning as heuristic methods in data that is regarded as ecologically ‘positive’. Unlike traditional critical studies of harmful environmental practices which expose deviant discursive practices, the starting point is discourse that concords with current mediated notions of environmental sustainability. The aim is not simply to give such contexts, and such discourse, publicity, and nor is it to seek solace in ‘discourse that inspires, encourages, heartens, discourse we like, that cheers us along’ (Martin 1999, pp. 51–52). Rather, it is to shed light on underlying processes at the level of ideologies (in the sense of Fairclough 2003: 9); to make manifest thoughts, feelings and discourses which are felt to be ‘positive’, in a mirror image of what occurs in CDA studies.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
The Need for Integrated Methodology – The National Museum of African American History and Culture
Creators: name: Abbamonte, Lucia
name: Antinucci, Raffaella
Publisher: name: mediAzioni
Year: 2022

description: For semiotically complex topics of investigation, such as museums, the need arises for an integrated analytical approach that enables the researcher to study the relationship between its different components and their possible social significance. The National Museum of African American History and Culture (NMAAHC), on the National Mall in Washington (DC), next to the Washington Monument, which marks the culmination of decades of efforts and struggles to commemorate African American history, is a case in point. A major representational objective of the museum is to rescue generations of black people from anonymity by showing how ingenious and resilient the people who endured slavery were, and how optimism, hope and spirituality – the typical US values – define African American culture as well. In order to investigate the interplay and evaluate the synergy of the multi-layered communicative dimensions of the NMAAHC, which is the major objective of this observational study, an integrated methodological approach was required. The resources of multimodal discourse analysis were thus integrated with the fine-grained tools of the Appraisal Framework for the verbal components, and with insights from museum studies. The socio-cognitive implications of the data of these observational analyses were discussed in the light of the relatively recent and ongoing efforts to reconsider USA history through the lens of the African American experience.
description: mediAzioni, Vol. 34 (2022): Updating Discourse/s on Method/s
Borel-Laplace Sum Rules with $τ$ decay data, using OPE with improved anomalous dimensions
Creators: name: Ayala, Cesar
name: Cvetic, Gorazd
name: Teca, Diego
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We perform numerical analysis of double-pinched Borel-Laplace QCD sum rules for the strangeless semihadronic $τ$-decay data. The $D=0$ contribution to the theoretical contour integral in the sum rules is evaluated by the (truncated) Fixed Order perturbation theory method (FO) and by the Principal Value (PV) of the Borel integration. We use for the full Adler function the Operator Product Expansion (OPE) with the terms $\sim \langle O_D \rangle$ of dimension $D=2 n$ where $2 \leq n \leq 5$ for the (V+A)-channel, and $2 \leq n \leq 7$ for the V-channel data. In our previous works [1,2], only the (V+A)-channel data was analysed. In this work, the analysis of a new set of V-channel data is performed as well. Further, a renormalon-motivated construction of the $D=0$ part of the Adler function is improved in the $u=3$ infrared renormalon sector, by involving the recently known information on the two principal noninteger values $k^{(j)}=γ^{(1)}(O_6^{(j)})/β_0$ of the effective leading-order anomalous dimensions. Additionally, the OPE of the Adler function has now the D=6 contribution with the principal anomalous dimension ($\sim α_s^{k^{(1)}}$), and terms of higher dimension (with zero anomalous dimension). Cross-checks of the obtained extracted values of $α_s$ and of the condensates were performed by reproduction of the (central) experimental values of several double-pinched momenta $a^{(2,n)}$. The averaged final extracted values of the (MSbar) coupling are: $α_s(m_τ^2) = 0.3169^{+0.0070}_{-0.0096}$, corresponding to $α_s(M_Z^2)=0.1183^{+0.0009}_{-0.0012}$.
description: 29 pages, 10 figures; v3: minor changes in the text, version as published in J.Phys.G
Mumford-Shah and Potts Regularization for Manifold-Valued Data with Applications to DTI and Q-Ball Imaging
Creators: name: Weinmann, Andreas
name: Demaret, Laurent
name: Storath, Martin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Optimization and Control (math.OC)
subject: Medical Physics (physics.med-ph)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Mumford-Shah and Potts functionals are powerful variational models for regularization which are widely used in signal and image processing; typical applications are edge-preserving denoising and segmentation. Being both non-smooth and non-convex, they are computationally challenging even for scalar data. For manifold-valued data, the problem becomes even more involved since typical features of vector spaces are not available. In this paper, we propose algorithms for Mumford-Shah and for Potts regularization of manifold-valued signals and images. For the univariate problems, we derive solvers based on dynamic programming combined with (convex) optimization techniques for manifold-valued data. For the class of Cartan-Hadamard manifolds (which includes the data space in diffusion tensor imaging), we show that our algorithms compute global minimizers for any starting point. For the multivariate Mumford-Shah and Potts problems (for image regularization) we propose a splitting into suitable subproblems which we can solve exactly using the techniques developed for the corresponding univariate problems. Our method does not require any a priori restrictions on the edge set and we do not have to discretize the data space. We apply our method to diffusion tensor imaging (DTI) as well as Q-ball imaging. Using the DTI model, we obtain a segmentation of the corpus callosum.