Assisted biomimetic electrostimulation therapy can improve the clinical pregnancy rate of patients with abnormal endometrial receptivity undergoing frozen-thawed embryo transfer cycles
Creators: name: Luo, Rong
name: Yang, Fang
name: Shen, Tao
name: Wang, Jiahui
name: Jin, Yihan
name: Lu, Jinchun
name: Liang, Yuanjiao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: This study aimed to explore whether assisted biomimetic electrostimulation (BES) therapy can improve clinical outcomes in patients with abnormal endometrial receptivity undergoing frozen-thawed embryo transfer (FET) cycles. We retrospectively collected data from 132 patients who underwent FET cycles and divided them into the BES (<i>n</i> = 86) and non-BES (NBES) groups (<i>n</i> = 46). The clinical pregnancy rate (55.8 vs. 37.0%), biochemical pregnancy rate (59.3 vs. 41.3%), and live birth rate (44.2 vs. 23.9%) of the BES group were significantly higher than those of the NBES group (<i>p</i> &lt; 0.05). No significant difference between the two groups was observed in endometrial thickness at FET day, embryo implantation rate, and early abortion rate (<i>p</i> &gt; 0.05). The logistic regression analysis indicated that blastocyst transfer (adjusted OR = 3.617; 1.337–9.783; <i>p</i> = 0.011) and BES (adjusted OR = 2.398; 1.094–5.256; <i>p</i> = 0.029) were positively associated with the clinical pregnancy rate. These results suggested that assisted BES therapy can improve clinical outcomes in patients with diseases affecting endometrial receptivity.Impact statement<b>What is already known on this subject?</b> Biomimetic electrostimulation (BES) therapy can increase endometrial thickness in patients with thin endometria undergoing embryo transfers and to some extent improve their clinical outcomes.<b>What do the results of this study add?</b> Assisted BES therapy can improve clinical pregnancy rates in patients with abnormal endometrial receptivity undergoing FET cycles (55.8 vs. 37.0%, <i>p</i> = 0.039). After adjusting for covariates, BES was still positively associated with the clinical pregnancy rate (adjusted OR = 2.398; 1.094–5.256; <i>p</i> = 0.029).<b>What are the implications of these findings for clinical practice and/or further research?</b> BES therapy can improve endometrial receptivity. Further studies are needed to understand its specific mechanisms. <b>What is already known on this subject?</b> Biomimetic electrostimulation (BES) therapy can increase endometrial thickness in patients with thin endometria undergoing embryo transfers and to some extent improve their clinical outcomes. <b>What do the results of this study add?</b> Assisted BES therapy can improve clinical pregnancy rates in patients with abnormal endometrial receptivity undergoing FET cycles (55.8 vs. 37.0%, <i>p</i> = 0.039). After adjusting for covariates, BES was still positively associated with the clinical pregnancy rate (adjusted OR = 2.398; 1.094–5.256; <i>p</i> = 0.029). <b>What are the implications of these findings for clinical practice and/or further research?</b> BES therapy can improve endometrial receptivity. Further studies are needed to understand its specific mechanisms.