cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optically Loaded Semiconductor Quantum Memory Register
Creators: name: Kim, Danny
name: Kiselev, Andrey A.
name: Ross, Richard S.
name: Rakher, Matthew T.
name: Jones, Cody
name: Ladd, Thaddeus D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We propose and analyze an optically loaded quantum memory exploiting capacitive coupling between self-assembled quantum dot molecules and electrically gated quantum dot molecules. The self-assembled dots are used for spin-photon entanglement, which is transferred to the gated dots for long-term storage or processing via a teleportation process heralded by single-photon detection. We illustrate a device architecture enabling this interaction and we outline its operation and fabrication. We provide self-consistent Poisson-Schroedinger simulations to establish the design viability and refine the design, and to estimate the physical coupling parameters and their sensitivities to dot placement. The device we propose generates heralded copies of an entangled state between a photonic qubit and a solid-state qubit with a rapid reset time upon failure. The resulting fast rate of entanglement generation is of high utility for heralded quantum networking scenarios involving lossy optical channels.
description: 16 pages, 5 figures
La brecha de género: Análisis de perfiles de estudiantes y profesionales en las áreas STEM
Creators: name: Amores García, L.
Publisher: name: Zenodo
Year: 2020
Subjects: STEM, brecha de género, perfiles, estudiantes actuales, estudiantes graduados, proyecto W-STEM, Europa, Latino América

description: Trabajo Fin de Máster Máster: TIC's en Educación: Análisis y Diseño de Procesos, Recursos y Prácticas Formativas Universidad de Salamanca Tutores Francisco José García Peñalvo y Juan José Mena Marcos. Calificación: Sobresaliente (9) Resumen A lo largo de los años siempre ha existido discriminación de las mujeres en casi todos los ámbitos de la vida, incluido el acceso a los estudios de nivel superior. Aunque esto ha ido disminuyendo con el tiempo, todavía hay muchos aspectos donde se puede ver una brecha de género, como es el caso de las áreas STEM. En ciertos países, como los de América Latina, dicha brecha es más evidente que en otros. Por ello, surgió el proyecto W-STEM, con el fin de mejorar la situación del género femenino en los niveles de educación superior en estos países. El presente trabajo de investigación se centra en una de las muchas acciones que se llevan a cabo dentro del proyecto; la recolección de perfiles de estudiantes y profesionales STEM de diferentes países europeos y latinoamericanos. El objetivo principal es conocer cuál es la situación en cuanto al género en las áreas STEM, para poder ayudar a los estudiantes de secundaria a elegir su futura carrera universitaria, aumentar su conciencia sobre la importancia de estas carreras y abordar los estereotipos asociados. Para recoger los datos se ha utilizado una encuesta, a la cual respondieron estudiantes actuales y estudiantes ya graduados en STEM. El análisis de esa información ha permitido conocer cuáles son sus principales percepciones sobre sus estudios, así como comprobar si existen diferencias dependiendo de si se han graduado ya o no, o si son de un género u otro. Los resultados han demostrado que las diferencias son mayores en función del primer aspecto que del segundo.
Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer
Creators: name: Wilson, Elizabeth M.
name: He, Bin
name: Bill, Heather M.
name: Fei, Xiaoyin
name: Gregory, Christopher W.
name: Ponguta, Liliana A.
name: French, Frank S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Growth of normal and neoplastic prostate is mediated by the androgen receptor (AR), a ligand-dependent transcription factor activated by high affinity androgen binding. The AR is highly expressed in recurrent prostate cancer cells that proliferate despite reduced circulating androgen. In this report, we show that epidermal growth factor (EGF) increases androgen-dependent AR transactivation in the recurrent prostate cancer cell line CWR-R1 through a mechanism that involves a post-transcriptional increase in the p160 coactivator transcriptional intermediary factor 2/glucocorticoid receptor interacting protein 1 (TIF2/GRIP1). Site-specific mutagenesis and selective MAPK inhibitors linked the EGF-induced increase in AR transactivation to phosphorylation of TIF2/GRIP1. EGF signaling increased the coimmunoprecipitation of TIF2 and AR. AR transactivation and its stimulation by EGF were reduced by small interfering RNA inhibition of TIF2/GRIP1 expression. The data indicate that EGF signaling through MAPK increases TIF2/GRIP1 coactivation of AR transactivation in recurrent prostate cancer.
(1696) Ann [Blackburn]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Revealing δ Cephei's Secret Companion and Intriguing Past
Creators: name: Anderson, Richard I.
name: Sahlmann, Johannes
name: Holl, Berry
name: Eyer, Laurent
name: Palaversa, Lovro
name: Mowlavi, Nami
name: Süveges, Maria
name: Roelens, Maroussia
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Classical Cepheid variable stars are crucial calibrators of the cosmic distance scale thanks to a relation between their pulsation periods and luminosities. Their archetype, δ Cephei, is an important calibrator for this relation. In this paper, we show that δ Cephei is a spectroscopic binary based on newly-obtained high-precision radial velocities. We combine these new data with literature data to determine the orbit, which has period 2201 days, semi-amplitude 1.5 km/s, and high eccentricity (e = 0.647). We re-analyze Hipparcos intermediate astrometric data to measure δ Cephei's parallax ($\varpi = 4.09 \pm 0.16$ mas) and find tentative evidence for an orbital signature, although we cannot claim detection. We estimate that Gaia will fully determine the astrometric orbit. Using the available information from spectroscopy, velocimetry, astrometry, and Geneva stellar evolution models ($M_{δCep} ~ 5.0 - 5.25 M_\odot$), we constrain the companion mass to within $0.2 < M_2 < 1.2 M_\odot$. We discuss the potential of ongoing and previous interactions between the companion and δ Cephei near pericenter passage, informing reported observations of circumstellar material and bow-shock. The orbit may have undergone significant changes due to a Kozai-Lidov mechanism driven by the outer (visual and astrometric) companion HD 213307. Our discovery of δ Cephei's nature as a spectroscopic binary exposes a hidden companion and reveals a rich and dynamical history of the archetype of classical Cepheid variables.
description: 31 pages (referee format), 10 figures, accepted for publication in The Astrophysical Journal
(1693) Charlotte Talbot
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Towards a definition of digital narratives in art museums
Creators: name: Hidalgo Urbaneja, María Isabel
Publisher: name: University of Glasgow
Year: 2020
Subjects: subject: museum studies, museology, art museums, digital narratology, digital storytelling, online resources, online publications, online publishing, online exhibitions.

description: This thesis defines art museums’ online resources as narratives in response to the following question: How can online resources, such as online exhibitions, online publications, and similar resources, be accurately and systematically defined? The aim of this definition is to provide a detailed, clear, and critical understanding of certain types of online resources, namely online exhibitions and online publications, that share attributes and functions. The two types of online resources contain and display exhibitions and artworks information, use similar interfaces and media, can serve similar audiences, and narrate the stories of the artworks. Based on the narrative character of both types, the definition comprehensively examines the spectrum of attributes online resources have and the implications of such attributes. Thus, the definition not only indicates what are online resources and their characteristics but also explains why online resources are the way they are and have certain characteristics, and how they function as narratives. These attributes are authorship, readership, temporality, spatiality, and mediality. In order to construct the definition, a systematic review of narratology and museum studies literature on narratives was pursued. The review of the literature was key to develop a comprehensive analysis of the phenomenon. Moreover, the methodology used in this thesis revised the traditional usage of narratology in museum studies research integrating empirical evidence. In this way, the narratological analysis moves away from the narrative text itself and also considers the production and consumption mechanisms of the narrative. The thesis employs six art museums’ online resources from Spain, the United States, and the United Kingdom as sources for the research. Data from seven museum professionals involved in the creation of those resources was collected with interviews. In the case of the scholarly audience, twenty scholars performed think-aloud protocol sessions while visiting the online resources.
Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function
Creators: name: Li, Lian
name: Rees, Howard D.
name: Ke, Hengming
name: Brown, Keith
name: Chin, Lih Shen
name: Wilkinson, Keith D.
name: Huai, Qing
name: Olzmann, James A.
name: Levey, Allan I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Mutations in DJ-1, a protein of unknown function, were recently identified as the cause for an autosomal recessive, early onset form of familial Parkinson's disease. Here we report that DJ-1 is a dimeric protein that exhibits protease activity but no chaperone activity. The protease activity was abolished by mutation of Cys-106 to Ala, suggesting that DJ-1 functions as a cysteine protease. Our studies revealed that the Parkinson's disease-linked L166P mutation impaired the intrinsic folding propensity of DJ-1 protein, resulting in a spontaneously unfolded structure that was incapable of forming a homodimer with itself or a heterodimer with wild-type DJ-1. Correlating with the disruption of DJ-1 structure, the L166P mutation abolished the catalytic function of DJ-1. Furthermore, as a result of protein misfolding, the L166P mutant DJ-1 was selectively polyubiquitinated and rapidly degraded by the proteasome. Together these findings provide insights into the molecular mechanism by which loss-of-function mutations in DJ-1 lead to Parkinson's disease.
Supplementary Table 2 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: List of 226 biomarkers significant in the two ethnic groups including Cox proportional hazards regression p-values. Red: 82 significant biomarker candidates were shared among Asian and White/Caucasian cohorts. Biomarkers significant only in the Asian cohort are labeled with green, and in the White/Caucasian cohort in blue. p-values in black are not significant.
Climate change sentiment on Twitter: An unsolicited public opinion poll
Creators: name: Cody, Emily M.
name: Reagan, Andrew J.
name: Mitchell, Lewis
name: Dodds, Peter Sheridan
name: Danforth, Christopher M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Computers and Society (cs.CY)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: The consequences of anthropogenic climate change are extensively debated through scientific papers, newspaper articles, and blogs. Newspaper articles may lack accuracy, while the severity of findings in scientific papers may be too opaque for the public to understand. Social media, however, is a forum where individuals of diverse backgrounds can share their thoughts and opinions. As consumption shifts from old media to new, Twitter has become a valuable resource for analyzing current events and headline news. In this research, we analyze tweets containing the word "climate" collected between September 2008 and July 2014. Through use of a previously developed sentiment measurement tool called the Hedonometer, we determine how collective sentiment varies in response to climate change news, events, and natural disasters. We find that natural disasters, climate bills, and oil-drilling can contribute to a decrease in happiness while climate rallies, a book release, and a green ideas contest can contribute to an increase in happiness. Words uncovered by our analysis suggest that responses to climate change news are predominately from climate change activists rather than climate change deniers, indicating that Twitter is a valuable resource for the spread of climate change awareness.
description: 11 pages, 10 figures
An Analysis of the Opportunity Cost of Korean Women Farmers
Creators: name: Kang, Hyejung
name: Kang, Hyejung
Publisher: name: Unknown
Year: 2009
Subjects: subject: Labor and Human Capital
subject: women farmers
subject: opportunity cost
subject: Tobit model

description: This paper evaluates the opportunity costs of various roles that Korean women farmers perform and examines the factors affecting those opportunity costs using Tobit model. The opportunity costs of unpaid housework, farm work, and local community work that women farmers are performing are investigated from survey data for women farmers in their 40s and 50s. The empirical evidence suggests that relatively younger women farmers with higher education express that they are more willing to pay for alternative laborers; that is, women farmers with higher human capitals tend to evaluate highly their opportunity costs in all kinds of work.
Mapping the Chevallier-Polarski-Linder parametrization onto Physical Dark Energy Models
Creators: name: Scherrer, Robert J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We examine the Chevallier-Polarski-Linder (CPL) parametrization, in the context of quintessence and barotropic dark energy models, to determine the subset of such models to which it can provide a good fit. The CPL parametrization gives the equation of state parameter $w$ for the dark energy as a linear function of the scale factor $a$, namely $w = w_0 + w_a(1-a)$. In the case of quintessence models, we find that over most of the $w_0$, $w_a$ parameter space the CPL parametrization maps onto a fairly narrow form of behavior for the potential $V(ϕ)$, while a one-dimensional subset of parameter space, for which $w_a = κ(1+w_0)$, with $κ$ constant, corresponds to a wide range of functional forms for $V(ϕ)$. For barotropic models, we show that the functional dependence of the pressure on the density, up to a multiplicative constant, depends only on $w_i = w_a + w_0$ and not on $w_0$ and $w_a$ separately. Our results suggest that the CPL parametrization may not be optimal for testing either type of model.
description: 11 pages, 5 figures, typo corrected in Eq. (17), to appear in Phys. Rev. D
Supplementary Table 4 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma.
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: List of 40 biomarker candidates associated with overall survival in the entire dataset including both Asian and White/Caucasian subjects at 0.1% FDR. Bold faced genes are significantly associated with OS in a multivariate Cox regression.
Heterogeneous Nuclear Ribonuclear Protein U Associates with YAP and Regulates Its Co-activation of Bax Transcription
Creators: name: Howell, Michael
name: Milgram, Sharon L.
name: Borchers, Christoph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Although initially described as a cytosolic scaffolding protein, YAP (Yes-associated protein of 65 kDa) is known to associate with multiple transcription factors in the nucleus. Using affinity chromatography and mass spectrometry, we show that YAP interacts with heterogeneous nuclear ribonuclear protein U (hnRNP U), an RNA- and DNA-binding protein enriched in the nuclear matrix that also plays a role in the regulation of gene expression. hnRNP U interacts specifically with the proline-rich amino terminus of YAP, a region of YAP that is not found in the related protein TAZ. Although hnRNP U and YAP localize to both the nucleus and the cytoplasm, YAP does not translocate to the nucleus in an hnRNP U-dependent manner. Furthermore, hnRNP U and YAP only interact in the nucleus, suggesting that the association between the two proteins is regulated. Co-expression of hnRNP U attenuates the ability of YAP to increase the activity of a p73-driven Bax-luciferase reporter plasmid. In contrast, hnRNP U has no effect when co-expressed with a truncated YAP protein lacking the hnRNP U-binding site. Because YAP is distinguished from the homologue TAZ by its proline-rich amino terminus, the YAP-hnRNP U interaction may uniquely regulate the nuclear function(s) of YAP. The YAP-hnRNP U interaction provides another mechanism of YAP transcriptional regulation.
(1694) Martha Blackburn
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Table 3 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Functional grouping of significant prognostic biomarker candidates in the Asian cohort by DAVID gene ontology analysis.
The Impact of an Electronic Health Record Intervention on Spirometry Completion in Patients with Chronic Obstructive Pulmonary Disease
Creators: name: Wang, Christine
name: Siff, Jonathan
name: Greco, Peter J.
name: Warren, Edward
name: Thornton, J. Daryl
name: Tarabichi, Yasir
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Spirometry is necessary to diagnose chronic obstructive pulmonary disease (COPD), yet a large proportion of patients are diagnosed and treated without having received testing. This study explored whether the effects of interventions using the electronic health record (EHR) to target patients diagnosed with COPD without confirmatory spirometry impacted the incidence rates of spirometry referrals and completions. This retrospective before and after study assessed the impact of provider-facing clinical decision support that identified patients who had a diagnosis of COPD but had not received spirometry. Spirometry referrals, completions, and results were ascertained 1.5 years prior to and 1.5 years after the interventions were initiated. Inhaler prescriptions by class were also tallied. There were 10,949 unique patients with a diagnosis of COPD who were eligible for inclusion. 4,895 patients (44.7%) were excluded because they had completed spirometry prior to the cohort start dates. The pre-intervention cohort consisted of 2,622 patients, while the post-intervention cohort had 3,392. Spirometry referral rates pre-intervention were 20.2% compared to 31.6% post-intervention (p < 0.001). Spirometry completion rates rose from 13.2% pre-intervention to 19.3% afterwards (p < 0.001). 61.7% (585 of 948) had no evidence of airflow obstruction. After excluding patients with a diagnosis of asthma, 25.8% (126 of 488) patients who had no evidence of airflow obstruction had prescriptions for long-acting bronchodilators or inhaled steroids. A concerted EHR intervention modestly increased spirometry referral and completion rates in patients with a diagnosis of COPD without prior spirometry and decreased misclassification of disease.
Microsatellite panel definition to characterize Leishmania strains isolated from human samples in an italian endemic region
Creators: name: Reale Stefano
name: Castelli Germano
name: Federica, Bruno
name: Pitti Rosario
name: Migliazzo Antonella
name: Tiziana, Lupo
name: Piazza Maria
name: Fabrizio, Vitale
Publisher: name: INFN Open Access Repository
Year: 2017

description: The Leishmaniasis affects people, domestic and wild animals in temperature, subtropical and tropical regions. The natural cycle involves phlebotominae sandfly vectors transmitting the parasite to the vertebrate host. The insects influence the epidemiology of the disease by their geographical distribution in the seasons and the specific vectorial capacity. Human Leishmania infections are increasing every year in Sicily, which represent the region with the highest endemic level of the disease in Italy. Among different approaches employed for the diagnostic the parasites isolation remains the gold standard.
NLO QCD Corrections to $η_c+h_c(1P)/ψ_{1,2}(1D)$ Production at B-factories
Creators: name: Chen, Long-Bin
name: Jiang, Jun
name: Qiao, Cong-Feng
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the next-to-leading order (NLO) quantum chromodynamics (QCD) corrections to double charmonium production processes $e^+e^-\toγ^*\toη_c+h_c(1P)/ψ_{1,2}(1D)$ within the non-relativistic QCD (NRQCD) factorization framework. We find that the corrections to $η_c+h_c(1P)$ production are positive, while those to $η_c+ψ_{1,2}(1D)$ are negative. Unlike the $J/ψ+ η_c$ case, all the corrections here are not large. Uncertainties in the renormalization scale, quark mass and running energy of center-of-mass are discussed, and the scale dependence of these processes is found to be greatly reduced with the NLO QCD corrections.
description: 5 pages, 7 figures; revised version
(1695) Thomas Blackburn
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures
Creators: name: Croteau, Deborah L.
name: Griffith, Jack D.
name: Lindsey-Boltz, Laura A.
name: Subramanian, Deepa
name: Sancar, Aziz
name: Sar, Funda
name: Hutsell, Stephanie Q.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Claspin is an essential protein for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human cells. Here we describe the purification and characterization of human Claspin. The protein has a ring-like structure and binds with high affinity to branched DNA molecules. These findings suggest that Claspin may be a component of the replication ensemble and plays a role in the replication checkpoint by directly associating with replication forks and with the various branched DNA structures likely to form at stalled replication forks because of DNA damage.
Role of closed paths in the path integral approach of statistical thermodynamics
Creators: name: Badiali, J. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Thermodynamics is independent of a description at a microscopic level consequently statistical thermodynamics must produce results independent of the coordinate system used to describe the particles and their interactions. In the path integral formalism the equilibrium properties are cal- culated by using closed paths and an euclidean coordinate system. We show that the calculations on these paths are coordinates independent. In the change of coordinate systems we consider those preserving the physics on which we focus. Recently it has been shown that the path integral formalism can be built from the real motion of particles. We consider the change of coordinates for which the equations of motion are unchanged. Thus we have to deal with the canonical trans- formations. The Lagrangian is not uniquely defined and a change of coordinates introduces in hamiltonians the partial time derivative of an arbitrary function. We have show that the closed paths does not contain any arbitrary ingredients. This proof is inspired by a method used in gauge theory. Closed paths appear as the keystone on which we may describe the equilibrium states in statistical thermodynamics.
description: J. Phys. C (conf) in press
Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin
Creators: name: Faucette, Stephanie
name: LeCluyse, Edward
name: Moore, Rick
name: Sueyoshi, Tatsuya
name: Negishi, Masahiko
name: Wang, Hongbing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Compared with its rodent orthologs, little is known about the chemical specificity of human constitutive androstane receptor (hCAR) and its regulation of hepatic enzyme expression. Phenytoin (PHY), a widely used antiepileptic drug, is a potent inducer of CYP2B6 in primary human hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in cell-based transfection assays at the same concentrations associated with potent induction of CYP2B6. Based on this observation, we hypothesized that PHY may be a selective activator of hCAR. In primary human hepatocytes, expression of CYP2B6 reporter genes containing phenobarbital-responsive enhancer module (PBREM) or PBREM/xenobiotic-responsive enhancer module (XREM) response elements were activated up to 14- and 28-fold, respectively, by 50 microm PHY. By contrast, parallel experiments in HepG2 cell lines co-transfected with an hPXR expression vector did not show increased reporter activity. These results indicated that a PXR-independent pathway, which is retained in primary hepatocytes, is responsible for PHY induction of CYP2B6. Further experiments revealed that PHY effectively translocates hCAR from the cytoplasm into the nucleus in both primary human hepatocytes and CAR(-/-) mice. Compared with vehicle controls, PHY administration significantly increased CYP2B6 reporter gene expression, when this reporter construct was delivered together with hCAR expression vector into CAR(-/-) mice. However, PHY did not increase reporter gene expression in CAR(-/-) mice in the absence of hCAR vector, implying that CAR is essential for mediating PHY induction of CYP2B6 gene expression. Taken together, these observations demonstrate that, in contrast to most of the known CYP2B6 inducers, PHY is a selective activator of CAR in humans.
Energy Exchange between Phononic and Electronic Subsystem Governing The Nonlinear Conduction in DCNQI$_2$Cu
Creators: name: Huewe, Florian
name: Steeger, Alexander
name: Bauer, Irene
name: Doerrich, Steffen
name: Strohriegl, Peter
name: Pflaum, Jens
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a dynamical study on the nonlinear conduction behaviour in the commensurate charge-density-wave phase of the quasi-one-dimensional conductor DCNQI$_2$Cu below 75 K. We can accurately simulate magnitude and time-dependence of the measured conductivity in response to large voltage pulses by accounting for the energy exchange between the phononic and electronic subsystems by means of an electrothermal model. Our simulations reveal a distinct non-equilibrium population of optical phonon states with an average energy of E$_{ph}$ = 19 meV being half the activation energy of about $Δ$E$_a$ = 39 meV observed in DC resistivity measurements. By inelastic scattering, this hot optical phonon bath generates additional charge-carrying excitations thus providing a multiplication effect while energy transferred to the acoustic phonons is dissipated out of the system via heat conduction. Therefore, in high electric fields a preferred interaction of charge-carrying excitations with optical phonons compared to acoustic phonon modes is considered to be responsible for the nonlinear conduction effects observed in DCNQI$_2$Cu.
Supplementary Table 5 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma.
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: List of 52 biomarker candidates associated with vascular invasion based on literature search.
Supplementary Table 1 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: The list of 318 biomarkers containing 305 individual genes and 13 composite-biomarkers out of the 355 relevant publications. Expression levels conferring worse prognosis are based on the original articles, not inevitably congruent with the results of the current analysis.
Sviluppo di una piattaforma bioinformatica per la gestione e la fruizione dei profili genetici identificativi di Apis mellifera allevata nel territorio siciliano.
Creators: name: Reale, S.
name: Sammarco
name: Oliveri
name: Massaro
name: , Lupo
name: Bruno, F.
name: Castelli, G.
name: Vitale, F.
Publisher: name: INFN Open Access Repository
Year: 2019
Subjects: Microsatelliti, Api, Structure

description: Many methods have been used to study biodiversity in honey bees but, currently, the most used method is short tandem repeats (STR) or microsatellites analysis. During the last 5 years almost 1025 honey bees families were genotyped using a panel of 12 microsatellites and their genetic profiles were included in a reference database collecting data about subspecies Apis mellifera ligustica and A. mellifera siciliana and their hybrids. The aim of this research was to develop a bioinformatics pipeline named “API Microsat Sicilia”, for the elaboration of the genetic data in Sicily. We integrated different softwares (Genmapper, Genalex, Structure, Familias) generally used to analyze microsatellite data, into a unique container simplifying the analysis. The platform is simple to use, web based, modular and it is accessible to beekeeping to check the genotypes of their animals
Supplementary Table 4 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: List of 40 biomarker candidates associated with overall survival in the entire dataset including both Asian and White/Caucasian subjects at 0.1% FDR. Bold faced genes are significantly associated with OS in a multivariate Cox regression.
Dynamics of a bond-disordered $S=1$ quantum magnet near $z=1$ criticality
Creators: name: Povarov, K. Yu.
name: Wulf, E.
name: Hüvonen, D.
name: Ollivier, J.
name: Paduan-Filho, A.
name: Zheludev, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Neutron scattering is used to study NiCl$_{2-2x}$Br$_{2x}\cdot$4SC(NH$_2$)$_2$, $x=0.06$, a bond-disordered modification of the well-known gapped $S=1$ antiferromagnetic quantum spin system NiCl$_{2}\cdot$4SC(NH$_2$)$_2$. The magnetic excitation spectrum throughout Brillouin zone is mapped out at $T=60$ mK using high-resolution time-of-flight spectroscopy. It is found that the dispersion of spin excitation is renormalized, as compared to that in the parent compound. The lifetime of excitations near the bottom of the band is substantially decreased. No localized states are found below the gap energy $Δ\simeq0.2$ meV. At the same time, localized zero wave vector states are detected above the top of the band. The results are consistent with a more or less continuous random distribution of bond strengths, and a discrete, possibly bimodal, distribution of single-ion anisotropies in the disordered material.
description: 11 pages, 10 figures, 3 tables
Shear Banding of Complex Fluids
Creators: name: Divoux, Thibaut
name: Fardin, Marc A.
name: Manneville, Sébastien
name: Lerouge, Sandra
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Even in simple geometries many complex fluids display non-trivial flow fields, with regions where shear is concentrated. The possibility for such shear banding has been known since several decades, but the recent years have seen an upsurge of studies offering an ever more precise understanding of the phenomenon. The development of new techniques to probe the flow on multiple scales and with increasing spatial and temporal resolution has opened the possibility for a synthesis of the many phenomena that could only have been thought of separately before. In this review, we bring together recent research on shear banding in polymeric and on soft glassy materials, and highlight their similarities and disparities.
description: 16 pages, 6 figures, 152 references. Submitted to Annual Review of Fluid Mechanics
Supplementary Table 5 from Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma
Creators: name: Menyhárt, Otília
name: Nagy, Ádám
name: Győrffy, Balázs
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: List of 52 biomarker candidates associated with vascular invasion based on literature search.
(1689) Robert Erskine Pollock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
STILBENE ST18 AND TERFENYL TR4: IN VITRO ACTIVITY AGAINST TRYPANOSOMA CRUZI
Creators: name: Catanzaro Simone
name: Castelli Germano
name: Federica, Bruno
name: Migliazzo Antonella
name: Galante Antonella
name: Manlio, Tolomeo
name: Fabrizio, Vitale
Publisher: name: INFN Open Access Repository
Year: 2018

description: Chagas disease is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors that are found only in the Americas. Chagas disease and Leishmaniasis are life-threatening illnesses caused by the protozoan parasites Leishmania spp. and Trypanosoma cruzi, respectively. They are known as “neglected diseases” due to the lack of effective drug treatments and the scarcity of research work devoted to them. Therefore, the development of novel and effective drugs is an important and urgent need. Natural products are an important source of bioactive molecules for the development of new drugs. Recently, studies showed an interesting cytotoxic action of Stilbene ST18 and the Terphenyl TR4 compounds in Leishmania.
 In this study, we evaluated the in vitro trypanocidal activity of ST18 and TR4 and Nifurtimox, drug used for the treatment of Chagas disease. In addition, we evaluated the compounds action in infected macrophages with Trypanosoma cruzi. Results showed that three compounds exhibited significant activity against Trypanosoma compared to Nifurtimox. ST18 and TR4 compounds inhibited Trypanosoma growth with IC50 values of 4.5 and 32 μM, respectively. The treatment of infected macrophages with trypanosomes with the IC90 compounds showed a reduction of infection compared to control: ST18 reduced the infected cells to 52 %, TR4 reduced the infected cells to 63%. In conclusion, these news compounds could be considered as promising lead drugs for the development of new therapies for the treatment of Chagas disease.
(1690) Dorothy Helen Ramsbottom
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Identification of a New Glycerol-3-phosphate Acyltransferase Isoenzyme, mtGPAT2, in Mitochondria
Creators: name: Coleman, Rosalind A.
name: Lewin, Tal M.
name: Lee, Douglas P.
name: Schwerbrock, Nicole M.J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian tissues, an N-ethylmaleimide (NEM)-sensitive isoform in the endoplasmic reticulum membrane (microsomal GPAT) and an NEM-resistant form in the outer mitochondrial membrane (mtGPAT). Although only mtGPAT has been cloned, the microsomal and mitochondrial GPAT isoforms can be distinguished, because they differ in acyl-CoA substrate preference, sensitivity to inhibition by dihydroxyacetone phosphate and polymixin B, temperature sensitivity, and ability to be activated by acetone. The preponderance of evidence supports a role for mtGPAT in synthesizing the precursors for triacylglycerol synthesis. In mtGPAT(-/-) mice, PCR genotyping and Northern analysis showed successful knockout of mtGPAT; however, we detected a novel NEM-sensitive GPAT activity in mitochondrial fractions and an anti-mtGPAT immunoreactive protein in liver mitochondria, but not in microsomes. Rigorous analysis using two-dimensional gel electrophoresis revealed that the anti-mtGPAT immunoreactive proteins in wild type and mtGPAT(-/-) liver mitochondria have different isoelectric points. These results suggested the presence of a second GPAT in liver mitochondria from mtGPAT(-/-) mice. Characterization of this GPAT activity in liver from mtGPAT null mice showed that, unlike the mtGPAT activity in wild type samples, activity in mtGPAT knockout mitochondria did not prefer palmitoyl-CoA, was sensitive to inactivation by NEM, was inhibited by dihydroxyacetone phosphate and polymixin B, was temperature-sensitive, and was not activated by acetone. We conclude that a novel GPAT (mtGPAT2) with antigenic epitopes similar to those of mtGPAT is detectable in mitochondria from the livers of mtGPAT(-/-) mice.
Imbalanced Base Excision Repair in Response to Folate Deficiency Is Accelerated by Polymerase β Haploinsufficiency
Creators: name: Kapoor, Diksha
name: Heydari, Ahmad R.
name: Nakamura, Jun
name: Cabelof, Diane C.
name: Raffoul, Julian J.
name: Abdalla, Hala
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The mechanism by which folate deficiency influences carcinogenesis is not well established, but a phenotype of DNA strand breaks, mutations, and chromosomal instability suggests an inability to repair DNA damage. To elucidate the mechanism by which folate deficiency influences carcinogenicity, we have analyzed the effect of folate deficiency on base excision repair (BER), the pathway responsible for repairing uracil in DNA. We observe an up-regulation in initiation of BER in liver of the folate-deficient mice, as evidenced by an increase in uracil DNA glycosylase protein (30%, p < 0.01) and activity (31%, p < 0.05). However, no up-regulation in either BER or its rate-determining enzyme, DNA polymerase beta (beta-pol) is observed in response to folate deficiency. Accordingly, an accumulation of repair intermediates in the form of DNA single strand breaks (37% increase, p < 0.03) is observed. These data indicate that folate deficiency alters the balance and coordination of BER by stimulating initiation without subsequently stimulating the completion of repair, resulting in a functional BER deficiency. In directly establishing that the inability to induce beta-pol and mount a BER response when folate is deficient is causative in the accumulation of toxic repair intermediates, beta-pol-haploinsufficient mice subjected to folate deficiency displayed additional increases in DNA single strand breaks (52% increase, p < 0.05) as well as accumulation in aldehydic DNA lesions (38% increase, p < 0.01). Since young beta-polhaploinsufficient mice do not spontaneously exhibit increased levels of these repair intermediates, these data demonstrate that folate deficiency and beta-pol haploinsufficiency interact to increase the accumulation of DNA damage. In addition to establishing a direct role for beta-pol in the phenotype expressed by folate deficiency, these data are also consistent with the concept that repair of uracil and abasic sites is more efficient than repair of oxidized bases.
Supplemental Figures_1-8.pdf from Molecular palaeontology illuminates the evolution of ecdysozoan vision.
Creators: name: Fleming, James F.
name: Kristensen, Reinhardt Møbjerg
name: Sørensen, Martin Vinther
name: Tae-Yoon S. Park
name: Kazuharu Arakawa
name: Blaxter, Mark
name: Rebecchi, Lorena
name: Guidetti, Roberto
name: Williams, Tom A.
name: Roberts, Nicholas W.
name: Vinther, Jakob
name: Pisani, Davide
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: A single PDF file containing Supplemental Figures 1 through 8, as described in the main text, alongside their figure legends
Constraining CPT-even and Lorentz-violating nonminimal couplings with the electron magnetic and electric dipole moments
Creators: name: Araujo, Jonas B.
name: Casana, Rodolfo
name: Ferreira, Manoel M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyse some dimension-five CPT-even and Lorentz-violating nonminimal couplings between fermionic and gauge fields in the context of the Dirac equation. After evaluating the nonrelativistic Hamiltonian, we discuss the behavior of the terms under discrete symmetries and analyse the implied effects. We then use the anomalous magnetic dipole moment and electron electric dipole moment measurements to reach upper bounds of $1$ part in $10^{20}$ and $10^{24}$ $\left( eV\right) ^{-1}$, improving the level of restriction on such couplings by at least 8 orders of magnitude. These upper bounds are also transferred to the Sun-centered frame by considering the Earth's rotational motion.
description: 6 pages, 1 table, revtex style, two columns, revised and final version