cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of Pollen-mediated gene flow ensures connectivity among spatially discrete sub-populations of Phalaenopsis pulcherrima, a tropical food-deceptive orchid
Creators: name: Zhang, Zhe
name: Gale, Stephan
name: Li, Ji-Hong
name: Fischer, Gunter
name: Ren, Ming-Xun
name: Song, Xi-Qiang
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 1: Table S1. Fruit-set in Phalaenopsis pulcherrima following artificial pollination treatments (self- and cross-pollination) and natural (open) pollination Table S2. Number of F1 seedlings for micropropagation, Table S3. Characterization and annealing temperatures (Ta) of 15 microsatellite loci developed for Phalaenopsis pulcherrima, .
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IX, Cart. 193 (11 H 78), f. 0239r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IX, Archives départementales de la Côte-d'Or, Cart. 193 (11 H 78), f. 0239r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IX, Archives départementales de la Côte-d'Or, Cart. 193 (11 H 78), f. 0239r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Extensive recombination challenges the utility of Sugarcane mosaic virus phylogeny and strain typing.
Creators: name: Braidwood, Luke
name: Müller, Sebastian Y
name: Baulcombe, David
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: Sugarcane mosaic virus (SCMV) is distributed worldwide and infects three major crops: sugarcane, maize, and sorghum. The impact of SCMV is increased by its interaction with Maize chlorotic mottle virus which causes the synergistic maize disease maize lethal necrosis. Here, we characterised maize lethal necrosis-infected maize from multiple sites in East Africa, and found that SCMV was present in all thirty samples. This distribution pattern indicates that SCMV is a major partner virus in the East African maize lethal necrosis outbreak. Consistent with previous studies, our SCMV isolates were highly variable with several statistically supported recombination hot- and cold-spots across the SCMV genome. The recombination events generate conflicting phylogenetic signals from different fragments of the SCMV genome, so it is not appropriate to group SCMV genomes by simple similarity.
COLUMN-BASED MATRIX APPROXIMATION WITH QUASI-POLYNOMIAL STRUCTURE
Creators: Praneeth Narayanamurthy
Selin Bac
Shaama Mallikarjun Sharada
Urbashi Mitra
Publisher: name: IEEE Signal Processing Society
Year: 2024

description: A novel matrix completion problem is considered herein:  observations based on fully sampled columns and quasi-polynomial side information is exploited.  The framework is motivated by quantum chemistry problems wherein full matrix computation is expensive, but partial computations only lead to column information. The proposed algorithm successfully estimates the row-space of a true matrix given a priori knowledge of the true matrix. A theoretical error bound is provided, which captures the possible inaccuracies of the side information. This work designs the first provable matrix approximation algorithm using just column samples. The proposed algorithm is validated via simulations which enable the characterization of the amount of information provided by the quasi-polynomial side information.
CROSS-MODAL AI ARCHITECTURES FOR AUDIO-VISUAL EMOTION RECOGNITION
Creators: name: Researchscholar
Publisher: name: Zenodo
Year: 2025

description: Emotion recognition technology has become a critical area in affective computing, aiming to enablemachines to understand human affect through various signals. While unimodal systems based on either audio orvisual data provide partial insights into emotions, they fall short in capturing the multimodal nature of humanemotional expression. Cross-modal Artificial Intelligence (AI) architectures integrate both audio and visual inputsto provide a more robust and holistic emotion recognition capability. This paper explores the foundationaltechnologies of cross-modal emotion recognition, including deep learning, feature fusion, and multimodalrepresentation learning. Practical use cases in virtual assistants, mental health diagnostics, education, andcustomer service are discussed, alongside real-world applications. Ethical concerns regarding privacy,surveillance, and emotional manipulation are examined, as well as limitations such as model interpretability,cultural variability, and data alignment challenges. Finally, the paper highlights future prospects includingadaptive emotion-aware systems, neurosymbolic AI, and the growing importance of context in emotionalmodeling. Cross-modal AI stands as a powerful tool for creating emotionally intelligent systems capable ofunderstanding and interacting with humans in deeper, more meaningful ways.
Controlling All-Optical Helicity-Dependent Switching in Engineered Rare-Earth Free Synthetic Ferrimagnets.
Creators: name: Liao, Jung-Wei
name: Vallobra, Pierre
name: O'Brien, Liam
name: Atxitia, Unai
name: Raposo, Victor
name: Petit, Dorothée
name: Vemulkar, Tarun
name: Malinowski, Gregory
name: Hehn, Michel
name: Martínez, Eduardo
name: Mangin, Stéphane
name: Cowburn, Russell P
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Ferromagnets
All‐optical Switching
Synthetic Ferrimagnets

description: All-optical helicity-dependent switching in ferromagnetic layers has revealed an unprecedented route to manipulate magnetic configurations by circularly polarized femtosecond laser pulses. In this work, rare-earth free synthetic ferrimagnetic heterostructures made from two antiferromagnetically exchange coupled ferromagnetic layers are studied. Experimental results, supported by numerical simulations, show that the designed structures enable all-optical switching which is controlled, not only by light helicity, but also by the relative Curie temperature of each ferromagnetic layer. Indeed, through the antiferromagnetic exchange coupling, the layer with the larger Curie temperature determines the final orientation of the other layer and so the synthetic ferrimagnet. For similar Curie temperatures, helicity-independent back switching is observed and the final magnetic configuration is solely determined by the initial magnetic state. This demonstration of electrically-detected, optical control of engineered rare-earth free heterostructures opens a novel route toward practical opto-spintronics.
Geometry of the free-sliding Bernoulli beam
Creators: name: Moreno, Giovanni
name: Stypa, Monika Ewa
Publisher: name: arXiv
Year: 2017
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 12X34

description: If a variational problem comes with no boundary conditions prescribed beforehand, and yet these arise as a consequence of the variation process itself, we speak of a free boundary values variational problem. Such is, for instance, the problem of finding the shortest curve whose endpoints can slide along two prescribed curves. There exists a rigorous geometric way to formulate this sort of problems on smooth manifolds with boundary, which we review here in a friendly self-contained way. As an application, we study a particular free boundary values variational problem, the free-sliding Bernoulli beam.
description: 12 pages
MOESM1 of Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study
Creators: name: Malerbi, Fernando
name: Regatieri, Caio
name: JoĂŁo Sa
name: Morales, Paulo
name: Farah, Michel
name: Dib, Sergio
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: TableÂ S1. Baseline and Follow up Clinical and Laboratory Data of Type 1 Albuminuric Patients.
Bound and gagged by neoliberalism: sustaining liberal democracy by unfettering community services
Creators: name: Walker, Christopher N.
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Community managed organisations are integral to liberal democracy. They enfranchise the vulnerable, facilitate discourse, and uphold the social, civil, and political rights which assure the equality of worth and dignity inherent to citizenship and democratic process. This study adopted a mixed method design within a pre-post, one-arm quasi-experiment to evaluate the efficacy and acceptability of a mobile social networking application, connected with a wearable tracker, to promote physical activity. Quantitative results were analyzed using descriptive and inferential statistics. Interviews and focus groups were conducted before and after the intervention to explore users' perspectives. Many years of neoliberal reform have, however, undermined service providers' operational agility and sustainability, rendering them ill-equipped to survive the next phase of neoliberalisation - the competitive market environment of the National Disability Insurance Scheme. Service providers' adaptability to these changes is, however, critical. Their actions over the next few years will have profound implications for Australian society, extending far beyond the consequences of interruptions in service to their consumers. As the mediators of citizen-state relations, whether - and how - community managed organisations survive competition, both with one another and with incoming for-profit providers, will substantively affect the nature of liberal democracy in Australia. This thesis adopts a semiotics-informed approach to understanding how community-workers reconcile fundamental conflicts arising from neoliberalisation of the welfare-state within which they are systematically and ontologically embedded. It advances a conceptual framework for understanding sensemaking, identity, and agency within dissonant reforms; discusses the implications for non-profit sustainability and liberal-democracy; and contributes to sensemaking and community-development literatures.
Autism and the right to education in the EU: policy mapping and scoping review of Nordic countries Denmark, Finland, and Sweden.
Creators: name: Van Kessel, Robin
name: Walsh, Sebastian
name: Ruigrok, Amber N V
name: Holt, Rosemary
name: Yliherva, Anneli
name: Kärnä, Eija
name: Moilanen, Irma
name: Hjörne, Eva
name: Johansson, Shruti Taneja
name: Schendel, Diana
name: Pedersen, Lennart
name: Jørgensen, Meta
name: Brayne, Carol
name: Baron-Cohen, Simon
name: Roman-Urrestarazu, Andres
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: Introduction:The universal right to education for people with disabilities has been highlighted by the Universal Declaration on Human Rights and the Convention on the Rights of Persons with Disabilities. In this paper, we mapped policies addressing the right to education and special education needs of autistic children in Denmark, Sweden, and Finland. Methods:A policy path analysis was carried out using a scoping review as an underlying framework for data gathering. Policy mapping was performed independently by both lead authors to increase reliability. Results and discussion:The values of the Universal Declaration of Human Rights and the Convention on the Rights of Persons with Disabilities have been closely translated into the respective education systems of the countries under study, offering special education needs services and support in mainstream education with the aim of including as many children into mainstream education as possible. Even though the education systems are comparable, the approaches between the countries under study are slightly different. Denmark and Sweden have passed several policies specifically geared towards special education needs, while Finland incorporates this more in general education policy. Conclusion:All countries under study have incorporated the values of the Universal Declaration of Human Rights and the Convention on the Rights of Persons with Disabilities in their respective education systems while emphasising the need to include as many children in the mainstream system as possible.
Seasonal drivers of understorey temperature buffering in temperate deciduous forests across Europe.
Creators: name: Zellweger, Florian
name: Coomes, David
name: Lenoir, Jonathan
name: Depauw, Leen
name: Maes, Sybryn L
name: Wulf, Monika
name: Kirby, Keith J
name: Brunet, Jörg
name: Kopecký, Martin
name: Máliš, František
name: Schmidt, Wolfgang
name: Heinrichs, Steffi
name: Den Ouden, Jan
name: Jaroszewicz, Bogdan
name: Buyse, Gauthier
name: Spicher, Fabien
name: Verheyen, Kris
name: De Frenne, Pieter
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Climate change
Global warming
Microclimate
Canopy density
forest structure
Macroclimate
Understorey
Temperature Buffering
Forest Composition

description: Aim:Forest understorey microclimates are often buffered against extreme heat or cold, with important implications for the organisms living in these environments. We quantified seasonal effects of understorey microclimate predictors describing canopy structure, canopy composition and topography (i.e., local factors) and the forest patch size and distance to the coast (i.e., landscape factors). Location:Temperate forests in Europe. Time period:2017-2018. Major taxa studied:Woody plants. Methods:We combined data from a microclimate sensor network with weather-station records to calculate the difference, or offset, between temperatures measured inside and outside forests. We used regression analysis to study the effects of local and landscape factors on the seasonal offset of minimum, mean and maximum temperatures. Results:The maximum temperature during the summer was on average cooler by 2.1 °C inside than outside forests, and the minimum temperatures during the winter and spring were 0.4 and 0.9 °C warmer. The local canopy cover was a strong nonlinear driver of the maximum temperature offset during summer, and we found increased cooling beneath tree species that cast the deepest shade. Seasonal offsets of minimum temperature were mainly regulated by landscape and topographic features, such as the distance to the coast and topographic position. Main conclusions:Forest organisms experience less severe temperature extremes than suggested by currently available macroclimate data; therefore, climate-species relationships and the responses of species to anthropogenic global warming cannot be modelled accurately in forests using macroclimate data alone. Changes in canopy cover and composition will strongly modulate the warming of maximum temperatures in forest understories, with important implications for understanding the responses of forest biodiversity and functioning to the combined threats of land-use change and climate change. Our predictive models are generally applicable across lowland temperate deciduous forests, providing ecologically important microclimate data for forest understories.
"I need my blanket when I'm scared": the nature and use of safety behaviours in children and adolescents
Creators: name: Chapman, Cindy
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Safety behaviours have been found to undermine successful exposure in the treatment of anxiety disorders for both adults and children. Although reliable measures of safety behaviour exist in the adult literature, no such measure has been developed specifically for child and adolescent populations. This thesis aimed to address this gap in the literature through two studies. Study One collected qualitative data from children and adolescents to explore their understanding, conceptualisation, and ability to report on safety behaviour use. This provided the foundation for Study Two, which focused on the development and psychometric evaluation of the Safety Behaviour Inventory for Children and Adolescents (SBICA), a measure of safety behaviours in youth. Three factors were identified from the SBICA, which reflected checking behaviours, behaviours related to image management, and behaviours related to physical protection. The SBICA and its subscales demonstrated strong internal consistency, test-retest reliability, construct validity, and the ability to discriminate between clinical and non-clinical participants. The SBICA was also responsive to the effects of treatment. Given its good psychometric properties, the SBICA will prove valuable for both research and clinical purposes.
The Development of Biophotovoltaic Systems for Power Generation and Biological Analysis.
Creators: name: Wey, Laura T
name: Bombelli, Paolo
name: Chen, Xiaolong
name: Lawrence, Joshua M
name: Rabideau, Clayton M
name: Rowden, Stephen J L
name: Zhang, Jenny Z
name: Howe, Christopher J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Photosynthesis
Fuel Cells
Electrode Architecture
Biophotovoltaics
Biophotoelectrochemistry

description: Biophotovoltaic systems (BPVs) resemble microbial fuel cells, but utilise oxygenic photosynthetic microorganisms associated with an anode to generate an extracellular electrical current, which is stimulated by illumination. Study and exploitation of BPVs have come a long way over the last few decades, having benefited from several generations of electrode development and improvements in wiring schemes. Power densities of up to 0.5 W m-2 and the powering of small electrical devices such as a digital clock have been reported. Improvements in standardisation have meant that this biophotoelectrochemical phenomenon can be further exploited to address biological questions relating to the organisms. Here, we aim to provide both biologists and electrochemists with a review of the progress of BPV development with a focus on biological materials, electrode design and interfacial wiring considerations, and propose steps for driving the field forward.
Simultaneous concentration and velocity maps in particle suspensions under shear from rheo-ultrasonic imaging
Creators: name: Saint-Michel, Brice
name: Bodiguel, Hugues
name: Meeker, Steven
name: Manneville, Sébastien
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We extend a previously developed ultrafast ultrasonic technique [Gallot et al., Rev. Sci. Instrum. 84, 045107 (2013)] to concentration field measurements in non-Brownian particle suspensions under shear. The technique provides access to time-resolved concentration maps within the gap of a Taylor-Couette cell simultaneously to local velocity measurements and standard rheological characterization. Benchmark experiments in homogeneous particle suspensions are used to calibrate the system. We then image heterogeneous concentration fields that result from centrifugation effects, from the classical Taylor-Couette instability and from sedimentation or shear-induced resuspension.
description: for publication in Phys. Rev. Applied
Investigating the role of life-history traits in mammalian genomes: supplementary material
Creators: name: Tang, Yun
name: Mai, Chun Lan
name: Yu, Jian Ping
name: Li, Da Yong
Publisher: name: Brill Online
Year: 2019
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified

description: Genome size evolution has
intrigued many evolutionary biologists. Ultimately, the
reasons that genomes have become large are proliferation of non-coding elements
and/or duplication events. The proximate causes are related to phylogeny, life-history
traits and environmental factors. Genome size in mammals exhibits little
interspecific variation compared with other taxa. The proximate causes and the
evolutionary patterns shaped by phylogeny or life-history traits are largely
unknown for mammals. Here, with a dataset of 121 species of mammals, we studied
the variations of genome size associated with life history using a comparative
quantitative analysis. The results showed that the genome size was positively associated
with body size, but not with four other life-history traits (i.e., gestation
period, weaning age, litter size, and longevity) in these species. For Primates,
Rodentia and Chiroptera, the genome size was not correlated with life-history
traits. Our results suggest that evolution of a large genome may result from
increased cell size and thus facilitate the evolution of large bodies.
Fitting Analysis using Differential Evolution Optimization (FADO): Spectral population synthesis through genetic optimization under self-consistency boundary conditions
Creators: name: Gomes, Jean Michel
name: Papaderos, Polychronis
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The goal of population spectral synthesis (PSS) is to decipher from the spectrum of a galaxy the mass, age and metallicity of its constituent stellar populations. This technique has been established as a fundamental tool in extragalactic research. It has been extensively applied to large spectroscopic data sets, notably the SDSS, leading to important insights into the galaxy assembly history. However, despite significant improvements over the past decade, all current PSS codes suffer from two major deficiencies that inhibit us from gaining sharp insights into the star-formation history (SFH) of galaxies and potentially introduce substantial biases in studies of their physical properties (e.g., stellar mass, mass-weighted stellar age and specific star formation rate). These are i) the neglect of nebular emission in spectral fits, consequently, ii) the lack of a mechanism that ensures consistency between the best-fitting SFH and the observed nebular emission characteristics of a star-forming (SF) galaxy. In this article, we present FADO (Fitting Analysis using Differential evolution Optimization): a conceptually novel, publicly available PSS tool with the distinctive capability of permitting identification of the SFH that reproduces the observed nebular characteristics of a SF galaxy. This so-far unique self-consistency concept allows us to significantly alleviate degeneracies in current spectral synthesis. The innovative character of FADO is further augmented by its mathematical foundation: FADO is the first PSS code employing genetic differential evolution optimization. This, in conjunction with other unique elements in its mathematical concept (e.g., optimization of the spectral library using artificial intelligence, convergence test, quasi-parallelization) results in key improvements with respect to computational efficiency and uniqueness of the best-fitting SFHs.
description: 25 pages, 12 figures, A&A accepted
Additional file 1 of Severe malaria intervention status in Nigeria: workshop meeting report
Creators: name: Shekarau, Emmanuel
name: Uzoanya, Miriam
name: Ogbulafor, Nnenna
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1: Meeting agenda.
Additional file 10 of How does tillage intensity affect soil organic carbon? A systematic review
Creators: name: Haddaway, Neal
name: Hedlund, Katarina
name: Jackson, Louise
name: Kätterer, Thomas
name: Lugato, Emanuele
name: Thomsen, Ingrid
name: Jørgensen, Helene
name: Per-Erik Isberg
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Additional file 10. Concentration SOC meta-analysis report.
A Friedrichs-Maz'ya inequality for functions of bounded variation
Creators: name: Rondi, Luca
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: Primary 46E35. Secondary 49Q15

description: The aim of this short note is to give an alternative proof, which applies to functions of bounded variation in arbitrary domains, of an inequality by Maz'ya that improves Friedrichs inequality. A remarkable feature of such a proof is that it is rather elementary, if the basic background in the theory of functions of bounded variation is assumed. Never the less, it allows to extend all the previously known versions of this fundamental inequality to a completely general version. In fact the inequality presented here is optimal in several respects. As already observed in previous proofs, the crucial step is to provide conditions under which a function of bounded variation on a bounded open set, extended to zero outside, has bounded variation on the whole space. We push such conditions to their limits. In fact, we give a sufficient and necessary condition if the open set has a boundary with $σ$-finite surface measure and a sufficient condition if the open set is fully arbitrary. Via a counterexample we show that such a general sufficient condition is sharp.
description: 12 pages. To appear in Mathematische Nachrichten
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.
Creators: name: Faravelli, Giulia
name: Raimondi, Sara
name: Marchese, Loredana
name: Partridge, Frederick A
name: Soria, Cristina
name: Mangione, P Patrizia
name: Canetti, Diana
name: Perni, Michele
name: Aprile, Francesco A
name: Zorzoli, Irene
name: Di Schiavi, Elia
name: Lomas, David A
name: Bellotti, Vittorio
name: Sattelle, David B
name: Giorgetti, Sofia
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural human variant of β2-microglobulin (D76N β2-m) is associated with a fatal familial form of systemic amyloidosis. Hitherto, no animal model has been available for studying in vivo the pathogenicity of this protein. We have established a transgenic C. elegans line, expressing the human D76N β2-m variant. Using the INVertebrate Automated Phenotyping Platform (INVAPP) and the algorithm Paragon, we were able to detect growth and motility impairment in D76N β2-m expressing worms. We also demonstrated the specificity of the β2-m variant in determining the pathological phenotype by rescuing the wild type phenotype when β2-m expression was inhibited by RNA interference (RNAi). Using this model, we have confirmed the efficacy of doxycycline, an inhibitor of the aggregation of amyloidogenic proteins, in rescuing the phenotype. In future, this C. elegans model, in conjunction with the INVAPP/Paragon system, offers the prospect of high-throughput chemical screening in the search for new drug candidates.
Additional file 1 of Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice
Creators: name: Cook, Anna K.
name: Greathouse, Kelsey M.
name: Manuel, Phaedra N.
name: Cooper, Noelle H.
name: Eberhardt, Juliana M.
name: Freeman, Cameron D.
name: Weber, Audrey J.
name: Herskowitz, Jeremy H.
name: Arrant, Andrew E.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Developmental Biology
subject: Science Policy

description: Supplementary Material 1
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Cart. 187 (11 H 72), f. 0030v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0030v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome III, Archives départementales de la Côte-d'Or, Cart. 187 (11 H 72), f. 0030v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Generalized Rao Test for Decentralized Detection of an Uncooperative Target
Creators: name: Ciuonzo, D.
name: Rossi, P. Salvo
name: Willett, P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We tackle distributed detection of a non-cooperative target with a Wireless Sensor Network (WSN). When the target is present, sensors observe an (unknown) deterministic signal with attenuation depending on the distance between the sensor and the (unknown) target positions, embedded in symmetricand unimodal noise. The Fusion Center (FC) receives quantized sensor observations through error-prone Binary Symmetric Channels (BSCs) and is in charge of performing a more-accurate global decision. The resulting problem is a two-sided parameter testing with nuisance parameters (i.e. the target position) present only under the alternative hypothesis. After introducing the Generalized Likelihood Ratio Test (GLRT) for the problem, we develop a novel fusion rule corresponding to a Generalized Rao (G-Rao) test, based on Davies' framework, to reduce the computational complexity. Also, a rationale for threshold-optimization is proposed and confirmed by simulations. Finally, the aforementioned rules are compared in terms of performance and computational complexity.
description: extended version of IEEE Signal Processing Letters
Cord compression defined by MRI is the driving factor behind the decision to operate in Degenerative Cervical Myelopathy despite poor correlation with disease severity.
Creators: name: Hilton, Bryn
name: Tempest-Mitchell, Jennifer
name: Davies, Benjamin M
name: Francis, Jibin
name: Mannion, Richard J
name: Trivedi, Rikin
name: Timofeev, Ivan
name: Crawford, John R
name: Hay, Douglas
name: Laing, Rodney J
name: Hutchinson, Peter J
name: Kotter, Mark R N
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: OBJECTIVES:The mainstay treatment for Degenerative Cervical Myelopathy (DCM) is surgical decompression. Not all cases, however, are suitable for surgery. Recent international guidelines advise surgery for moderate to severe disease as well as progressive mild disease. The goal of this study was to examine the factors in current practice that drive the decision to operate in DCM. STUDY DESIGN:Retrospective cohort study. METHODS:1 year of cervical spine MRI scans (N = 1123) were reviewed to identify patients with DCM with sufficient clinical documentation (N = 39). Variables at surgical assessment were recorded: age, sex, clinical signs and symptoms of DCM, disease severity, and quantitative MRI measures of cord compression. Bivariate correlations were used to compare each variable with the decision to offer the patient an operation. Subsequent multivariable analysis incorporated all significant bivariate correlations. RESULTS:Of the 39 patients identified, 25 (64%) were offered an operation. The decision to operate was significantly associated with narrower non-pathological canal and cord diameters as well as cord compression ratio, explaining 50% of the variance. In a multivariable model, only cord compression ratio was significant (p = 0.017). Examination findings, symptoms, functional disability, disease severity, disease progression, and demographic factors were all non-significant. CONCLUSIONS:Cord compression emerged as the main factor in surgical decision-making prior to the publication of recent guidelines. Newly identified predictors of post-operative outcome were not significantly associated with decision to operate.
Discourse and the framing of risk
Creators: name: Firkins, Arthur Stuart
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis applies frame analysis (Goffman, 1974; Gumperz, 1982) to the understanding of how risk situations are framed through discourse. It focuses on four professional research sites predominately concerned with risk communication. The thesis develops an understanding of contextualist (social-cultural) theories of risk and pairs this with discourse - interactional approaches to explore how situations of risk are framed though the written accounts of institutional members. Frame analysis is further developed as a method for systematically making sense of discourse complexity, and utilized to understand how the institutional member has aligned situational and cultural frames to construct the account. The thesis both identifies and focuses its analysis on critical moments in the communication of risk, drawing on written as opposed to spoken accounts. Specifically, the thesis suggests that institutional members use the resources of discourse to render visible the 'risk situation at hand' and in so doing frame a particular view of risk which aims to steer action in particular directions. In addition, the thesis argues that institutional members foreground particular 'framing devices' that serve to both attenuate or amplify risk aspects of situations The study of written accounts of risk, it is argued, offers risk communicators insights into how institutional members construe risk within given contexts of situation as they seek to both anchor and align the situation to influence the actions of community members.
MOESM10 of How does tillage intensity affect soil organic carbon? A systematic review
Creators: name: Haddaway, Neal
name: Hedlund, Katarina
name: Jackson, Louise
name: KĂ¤Tterer, Thomas
name: Lugato, Emanuele
name: Thomsen, Ingrid
name: JĂ¸Rgensen, Helene
name: Per-Erik Isberg
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file 10. Concentration SOC meta-analysis report.
Delayed damage accumulation by athermal suppression of defect production in concentrated solid solution alloys
Creators: name: G. Velişa
name: E. Wendler
name: S. Zhao
name: K. Jin
name: H. Bei
name: W. J. Weber
name: Y. Zhang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology

description: A combined experimental and computational evaluation of damage accumulation in ion-irradiated Ni, NiFe, and NiFeCoCr is presented. A suppressed damage accumulation, at early stages (low-fluence irradiations), is revealed in NiFeCoCr, with a linear dependence as a function of ion fluence, in sharp contrast to Ni and NiFe. This effect, observed at 16 K, is attributed to the complex energy landscape in these alloys that limits defect mobility and therefore enhances defect interaction and recombination. These results, together with previous room-temperature and high-temperature investigations, suggest ‘self-healing’ as an intrinsic property of complex alloys that is not a thermally activated process. IMPACT STATEMENT A combined experimental and computational evaluation reveals a remarkable delayed damage accumulation due to significant athermal suppression of defect production in ion-irradiated concentrated solid solution alloys at 16 K.
Extreme Variability in a Broad Absorption Line Quasar
Creators: name: Stern, Daniel
name: Graham, Matthew J.
name: Arav, Nahum
name: Djorgovski, S. G.
name: Chamberlain, Carter
name: Barth, Aaron J.
name: Donalek, Ciro
name: Drake, Andrew J.
name: Glikman, Eilat
name: Jun, Hyunsung D.
name: Mahabal, Ashish A.
name: Steidel, Charles C.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: CRTS J084133.15+200525.8 is an optically bright quasar at z=2.345 that has shown extreme spectral variability over the past decade. Photometrically, the source had a visual magnitude of V~17.3 between 2002 and 2008. Then, over the following five years, the source slowly brightened by approximately one magnitude, to V~16.2. Only ~1 in 10,000 quasars show such extreme variability, as quantified by the extreme parameters derived for this quasar assuming a damped random walk model. A combination of archival and newly acquired spectra reveal the source to be an iron low-ionization broad absorption line (FeLoBAL) quasar with extreme changes in its absorption spectrum. Some absorption features completely disappear over the 9 years of optical spectra, while other features remain essentially unchanged. We report the first definitive redshift for this source, based on the detection of broad H-alpha in a Keck/MOSFIRE spectrum. Absorption systems separated by several 1000 km/s in velocity show coordinated weakening in the depths of their troughs as the continuum flux increases. We interpret the broad absorption line variability to be due to changes in photoionization, rather than due to motion of material along our line of sight. This source highlights one sort of rare transition object that astronomy will now be finding through dedicated time-domain surveys.
description: 6 pages, 4 figures; accepted for publication in ApJ
AIOS: LLM Agent Operating System
Creators: name: Mei, Kai
name: Li, Zelong
name: Xu, Shuyuan
name: Ye, Ruosong
name: Ge, Yingqiang
name: Zhang, Yongfeng
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Natural language processing
subject: Artificial intelligence
subject: Operating systems

description: The integration and deployment of large language model (LLM)-based intelligent agents have been fraught with challenges that compromise their efficiency and efficacy. Among these issues are sub-optimal scheduling and resource allocation of agent requests over the LLM, the difficulties in maintaining context during interactions between agent and LLM, and the complexities inherent in integrating heterogeneous agents with different capabilities and specializations. The rapid increase of agent quantity and complexity further exacerbates these issues, often leading to bottlenecks and sub-optimal utilization of resources. Inspired by these challenges, this paper presents AIOS, an LLM agent operating system, which embeds large language model into operating systems (OS) as the brain of the OS, enabling an operating system "with soul"--an important step towards AGI. Specifically, AIOS is designed to optimize resource allocation, facilitate context switch across agents, enable concurrent execution of agents, provide tool service for agents, and maintain access control for agents. We present the architecture of such an operating system, outline the core challenges it aims to resolve, and provide the basic design and implementation of the AIOS. Our experiments on concurrent execution of multiple agents demonstrate the reliability and efficiency of our AIOS modules. Through this, we aim to not only improve the performance and efficiency of LLM agents but also to pioneer for better development and deployment of the AIOS ecosystem in the future. The project is open-source at https://github.com/agiresearch/AIOS.
Arrêt du parlement, qui ordonne aux Échevins de Douay de tenir les Audiences ordinaires, pour l'instruction et le jugement des procès, dans tous les temps, à l’exception de celui de la foire, auquel ils se conformeront à l'usage usité
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
name: Six, Philippe-Josse-Auguste-Joseph (1732-1793)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019
Subjects: Organisation judiciaire
Justice municipale
Échevin
Manifestation commerciale

description: Source: http://nordnum.univ-lille.fr/ark:/72505/a0115224001360im5Ol/from/a011522400136ypxWl2
description: Source: NAKALONA
description: Coverage: Parlement de Flandre
description: issued: 14/02/2019
Biased decoy-state reference-frame-independent quantum key distribution
Creators: name: Zhu, Jian-Rong
name: Zhang, Chun-Mei
name: Guo, Guang-Can
name: Wang, Qin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Without actively aligning the reference frames, the reference-frame-independent quantum key distribution (RFI-QKD) can generate secure keys even when the reference frames drift slowly. Here, we propose a new scheme on the decoy-state RFI-QKD, where the basis assignments of two legitimate parties are biased, reducing the fraction of mismatched-basis data. When accounting for statistical fluctuations under different misalignments of reference frames, we investigate the performance of biased decoy-state RFI-QKD with full parameter optimization. We also make a clear comparison between the new scheme with other practical schemes, e.g., unbiased decoy-state RFI-QKD and biased decoy-state BB84-QKD. Simulation results demonstrate that the new proposed biased decoy-state RFI-QKD can significantly improve the performance (secret key rate and secure transmission distance) of practical QKD systems.
description: 9pages, 3 figures
Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer.
Creators: name: Dobosz, Paula
name: Stempor, Przemysław A
name: Roszik, Jason
name: Herman, Amir
name: Layani, Adi
name: Berger, Raanan
name: Avni, Dror
name: Sidi, Yechezkel
name: Leibowitz-Amit, Raya
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: Immune checkpoint inhibitors have revolutionized cancer therapy, but not all cancers respond to the currently available drugs, and even within cancers considered responsive to such modality, response rates range between 15 and 40%, depending on the cancer type, the line of treatment, and yet unknown clinical/molecular factors. Coordinated expression of checkpoint proteins was shown to occur on T cells, probably allowing fine-tuning of the signal transmitted to the cell. We performed a bioinformatic analysis of the expression of putative checkpoint mRNAs at the cancer side of the immunological synapse from the bladder cancer tumorgenome atlas (TCGA) database. Fifteen mRNAs, corresponding to both coinhibitory and costimulatory checkpoints, were shown to be expressed above a designated threshold. Of these, seven mRNAs were found to be coexpressed: CD277, PD-1L, CD48, CD86, galectin-9, TNFRSF14 (HVEM), and CD40. The expression of 2 of these mRNAs-BTN3A1 (CD277) and TNFRSF14 (HVEM)-was positively correlated with overall survival in the TCGA database. All these seven mRNA share putative binding sites of a few transcription factors (TFs). Of these, the expression of the TF BACH-2 was positively correlated with the expression of checkpoint mRNAs from the network. This suggests a joint transcriptional regulation on the expression of checkpoint mRNAs at the bladder tumor side of the immunological synapse.