Associations of autozygosity with a broad range of human phenotypes
Creators: name: Clark, David W
name: Okada, Yukinori
name: Moore, Kristjan H S
name: Mason, Dan
name: Pirastu, Nicola
name: Gandin, Ilaria
name: Mattsson, Hannele
name: Barnes, Catriona L K
name: Lin, Kuang
name: Zhao, Jing Hua
name: Deelen, Patrick
name: Rohde, Rebecca
name: Schurmann, Claudia
name: Guo, Xiuqing
name: Giulianini, Franco
name: Zhang, Weihua
name: Medina-Gomez, Carolina
name: Karlsson, Robert
name: Bao, Yanchun
name: Bartz, Traci M
name: Baumbach, Clemens
name: Biino, Ginevra
name: Bixley, Matthew J
name: Brumat, Marco
name: Chai, Jin-Fang
name: Corre, Tanguy
name: Cousminer, Diana L
name: Dekker, Annelot M
name: Eccles, David A
name: Van Eijk, Kristel R
name: Fuchsberger, Christian
name: Gao, He
name: Germain, Marine
name: Gordon, Scott D
name: De Haan, Hugoline G
name: Harris, Sarah E
name: Hofer, Edith
name: Huerta-Chagoya, Alicia
name: Igartua, Catherine
name: Jansen, Iris E
name: Jia, Yucheng
name: Kacprowski, Tim
name: Karlsson, Torgny
name: Kleber, Marcus E
name: Li, Shengchao Alfred
name: Li-Gao, Ruifang
name: Mahajan, Anubha
name: Matsuda, Koichi
name: Meidtner, Karina
name: Meng, Weihua
name: Montasser, May E
name: Van Der Most, Peter J
name: Munz, Matthias
name: Nutile, Teresa
name: Palviainen, Teemu
name: Prasad, Gauri
name: Prasad, Rashmi B
name: Priyanka, Tallapragada Divya Sri
name: Rizzi, Federica
name: Salvi, Erika
name: Sapkota, Bishwa R
name: Shriner, Daniel
name: Skotte, Line
name: Smart, Melissa C
name: Smith, Albert Vernon
name: Van Der Spek, Ashley
name: Spracklen, Cassandra N
name: Strawbridge, Rona J
name: Tajuddin, Salman M
name: Trompet, Stella
name: Turman, Constance
name: Verweij, Niek
name: Viberti, Clara
name: Wang, Lihua
name: Warren, Helen R
name: Wootton, Robyn E
name: Yanek, Lisa R
name: Yao, Jie
name: Yousri, Noha A
name: Zhao, Wei
name: Adeyemo, Adebowale A
name: Afaq, Saima
name: Aguilar-Salinas, Carlos Alberto
name: Akiyama, Masato
name: Albert, Matthew L
name: Allison, Matthew A
name: Alver, Maris
name: Aung, Tin
name: Azizi, Fereidoun
name: Bentley, Amy R
name: Boeing, Heiner
name: Boerwinkle, Eric
name: Borja, Judith B
name: De Borst, Gert J
name: Bottinger, Erwin P
name: Broer, Linda
name: Campbell, Harry
name: Chanock, Stephen
name: Chee, Miao-Li
name: Chen, Guanjie
name: Chen, Yii-Der I
name: Chen, Zhengming
name: Chiu, Yen-Feng
name: Cocca, Massimiliano
name: Collins, Francis S
name: Concas, Maria Pina
name: Corley, Janie
name: Cugliari, Giovanni
name: Van Dam, Rob M
name: Damulina, Anna
name: Daneshpour, Maryam S
name: Day, Felix R
name: Delgado, Graciela E
name: Dhana, Klodian
name: Doney, Alexander S F
name: Dörr, Marcus
name: Doumatey, Ayo P
name: Dzimiri, Nduna
name: Ebenesersdóttir, S Sunna
name: Elliott, Joshua
name: Elliott, Paul
name: Ewert, Ralf
name: Felix, Janine F
name: Fischer, Krista
name: Freedman, Barry I
name: Girotto, Giorgia
name: Goel, Anuj
name: Gögele, Martin
name: Goodarzi, Mark O
name: Graff, Mariaelisa
name: Granot-Hershkovitz, Einat
name: Grodstein, Francine
name: Guarrera, Simonetta
name: Gudbjartsson, Daniel F
name: Guity, Kamran
name: Gunnarsson, Bjarni
name: Guo, Yu
name: Hagenaars, Saskia P
name: Haiman, Christopher A
name: Halevy, Avner
name: Harris, Tamara B
name: Hedayati, Mehdi
name: Van Heel, David A
name: Hirata, Makoto
name: Höfer, Imo
name: Hsiung, Chao Agnes
name: Huang, Jinyan
name: Hung, Yi-Jen
name: Ikram, M Arfan
name: Jagadeesan, Anuradha
name: Jousilahti, Pekka
name: Kamatani, Yoichiro
name: Kanai, Masahiro
name: Kerrison, Nicola D
name: Kessler, Thorsten
name: Khaw, Kay-Tee
name: Khor, Chiea Chuen
name: De Kleijn, Dominique P V
name: Koh, Woon-Puay
name: Kolcic, Ivana
name: Kraft, Peter
name: Krämer, Bernhard K
name: Kutalik, Zoltán
name: Kuusisto, Johanna
name: Langenberg, Claudia
name: Launer, Lenore J
name: Lawlor, Deborah A
name: Lee, I-Te
name: Lee, Wen-Jane
name: Lerch, Markus M
name: Li, Liming
name: Liu, Jianjun
name: Loh, Marie
name: London, Stephanie J
name: Loomis, Stephanie
name: Lu, Yingchang
name: Luan, Jian’an
name: Mägi, Reedik
name: Manichaikul, Ani W
name: Manunta, Paolo
name: Másson, Gísli
name: Matoba, Nana
name: Mei, Xue W
name: Meisinger, Christa
name: Meitinger, Thomas
name: Mezzavilla, Massimo
name: Milani, Lili
name: Millwood, Iona Y
name: Momozawa, Yukihide
name: Moore, Amy
name: Morange, Pierre-Emmanuel
name: Moreno-Macías, Hortensia
name: Mori, Trevor A
name: Morrison, Alanna C
name: Muka, Taulant
name: Murakami, Yoshinori
name: Murray, Alison D
name: De Mutsert, Renée
name: Mychaleckyj, Josyf C
name: Nalls, Mike A
name: Nauck, Matthias
name: Neville, Matt J
name: Nolte, Ilja M
name: Ong, Ken K
name: Orozco, Lorena
name: Padmanabhan, Sandosh
name: Pálsson, Gunnar
name: Pankow, James S
name: Pattaro, Cristian
name: Pattie, Alison
name: Polasek, Ozren
name: Poulter, Neil
name: Pramstaller, Peter P
name: Quintana-Murci, Lluis
name: Räikkönen, Katri
name: Ralhan, Sarju
name: Rao, Dabeeru C
name: Van Rheenen, Wouter
name: Rich, Stephen S
name: Ridker, Paul M
name: Rietveld, Cornelius A
name: Robino, Antonietta
name: Van Rooij, Frank J A
name: Ruggiero, Daniela
name: Saba, Yasaman
name: Sabanayagam, Charumathi
name: Sabater-Lleal, Maria
name: Sala, Cinzia Felicita
name: Salomaa, Veikko
name: Sandow, Kevin
name: Schmidt, Helena
name: Scott, Laura J
name: Scott, William R
name: Sedaghati-Khayat, Bahareh
name: Sennblad, Bengt
name: Van Setten, Jessica
name: Sever, Peter J
name: Sheu, Wayne H-H
name: Shi, Yuan
name: Shrestha, Smeeta
name: Shukla, Sharvari Rahul
name: Sigurdsson, Jon K
name: Sikka, Timo Tonis
name: Singh, Jai Rup
name: Smith, Blair H
name: Stančáková, Alena
name: Stanton, Alice
name: Starr, John M
name: Stefansdottir, Lilja
name: Straker, Leon
name: Sulem, Patrick
name: Sveinbjornsson, Gardar
name: Swertz, Morris A
name: Taylor, Adele M
name: Taylor, Kent D
name: Terzikhan, Natalie
name: Tham, Yih-Chung
name: Thorleifsson, Gudmar
name: Thorsteinsdottir, Unnur
name: Tillander, Annika
name: Tracy, Russell P
name: Tusié-Luna, Teresa
name: Tzoulaki, Ioanna
name: Vaccargiu, Simona
name: Vangipurapu, Jagadish
name: Veldink, Jan H
name: Vitart, Veronique
name: Völker, Uwe
name: Vuoksimaa, Eero
name: Wakil, Salma M
name: Waldenberger, Melanie
name: Wander, Gurpreet S
name: Wang, Ya Xing
name: Wareham, Nicholas J
name: Wild, Sarah
name: Yajnik, Chittaranjan S
name: Yuan, Jian-Min
name: Zeng, Lingyao
name: Zhang, Liang
name: Zhou, Jie
name: Amin, Najaf
name: Asselbergs, Folkert W
name: Bakker, Stephan J L
name: Becker, Diane M
name: Lehne, Benjamin
name: Bennett, David A
name: Van Den Berg, Leonard H
name: Berndt, Sonja I
name: Bharadwaj, Dwaipayan
name: Bielak, Lawrence F
name: Bochud, Murielle
name: Boehnke, Mike
name: Bouchard, Claude
name: Bradfield, Jonathan P
name: Brody, Jennifer A
name: Campbell, Archie
name: Carmi, Shai
name: Caulfield, Mark J
name: Cesarini, David
name: Chambers, John C
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name: Cheng, Ching-Yu
name: Ciullo, Marina
name: Cornelis, Marilyn
name: Cusi, Daniele
name: Smith, George Davey
name: Deary, Ian J
name: Dorajoo, Rajkumar
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name: Ellinghaus, David
name: Erdmann, Jeanette
name: Eriksson, Johan G
name: Evangelou, Evangelos
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name: Feenstra, Bjarke
name: Feitosa, Mary
name: Foisy, Sylvain
name: Franke, Andre
name: Friedlander, Yechiel
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name: Gonzalez, Clicerio
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name: Grant, Struan F A
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name: Gudnason, Vilmundur
name: Gyllensten, Ulf
name: Hakonarson, Hakon
name: Hamsten, Anders
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name: Heng, Chew-Kiat
name: Hicks, Andrew A
name: Hochner, Hagit
name: Huikuri, Heikki
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name: Johannesson, Magnus
name: Johansson, Åsa
name: Jonas, Jost B
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name: Kaprio, Jaakko
name: Kardia, Sharon L. R.
name: Karpe, Fredrik
name: Kumari, Meena
name: Laakso, Markku
name: Van Der Laan, Sander W
name: Lahti, Jari
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name: Lea, Rodney A
name: Lieb, Wolfgang
name: Lumley, Thomas
name: Martin, Nicholas G
name: März, Winfried
name: Matullo, Giuseppe
name: McCarthy, Mark I
name: Medland, Sarah E
name: Merriman, Tony R
name: Metspalu, Andres
name: Meyer, Brian F
name: Mohlke, Karen L
name: Montgomery, Grant W
name: Mook-Kanamori, Dennis
name: Munroe, Patricia B
name: North, Kari E
name: Nyholt, Dale R
name: O’connell, Jeffery R
name: Ober, Carole
name: Oldehinkel, Albertine J
name: Palmas, Walter
name: Palmer, Colin
name: Pasterkamp, Gerard G
name: Patin, Etienne
name: Pennell, Craig E
name: Perusse, Louis
name: Peyser, Patricia A
name: Pirastu, Mario
name: Polderman, Tinca J. C.
name: Porteous, David J
name: Posthuma, Danielle
name: Psaty, Bruce M
name: Rioux, John D
name: Rivadeneira, Fernando
name: Rotimi, Charles
name: Rotter, Jerome I
name: Rudan, Igor
name: Den Ruijter, Hester M
name: Sanghera, Dharambir K
name: Sattar, Naveed
name: Schmidt, Reinhold
name: Schulze, Matthias B
name: Schunkert, Heribert
name: Scott, Robert A
name: Shuldiner, Alan R
name: Sim, Xueling
name: Small, Neil
name: Smith, Jennifer A
name: Sotoodehnia, Nona
name: Tai, E-Shyong
name: Teumer, Alexander
name: Timpson, Nicholas J
name: Toniolo, Daniela
name: Tregouet, David-Alexandre
name: Tuomi, Tiinamaija
name: Vollenweider, Peter
name: Wang, Carol A
name: Weir, David R
name: Whitfield, John B
name: Wijmenga, Cisca
name: Wong, Tien-Yin
name: Wright, John
name: Yang, Jingyun
name: Yu, Lei
name: Zemel, Babette S
name: Zonderman, Alan B
name: Perola, Markus
name: Magnusson, Patrik K. E.
name: Uitterlinden, André G
name: Kooner, Jaspal S
name: Chasman, Daniel I
name: Loos, Ruth J. F.
name: Franceschini, Nora
name: Franke, Lude
name: Haley, Chris S
name: Hayward, Caroline
name: Walters, Robin G
name: Perry, John R. B.
name: Esko, Tōnu
name: Helgason, Agnar
name: Stefansson, Kari
name: Joshi, Peter K
name: Kubo, Michiaki
name: Wilson, James F
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/208/1397
/631/208/205
/631/208/721
/631/208/730
article

description: Abstract: In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for &gt;1.4 million individuals, we show that FROH is significantly associated (p &lt; 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.