Additional file 1 of Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease
Creators: name: Kim, Youngwon
name: Yeung, Shiu Lun Au
name: Sharp, Stephen J.
name: Wang, Mengyao
name: Jang, Haeyoon
name: Luo, Shan
name: Brage, Soren
name: Wijndaele, Katrien
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Virology

description: Additional file 1: Figure S1. A participant flow chart. Figure S2. Distribution of the calculated polygenic risk score (PRS) for coronary heart disease using 300 uncorrelated SNPs. Figure S3. Cubic spline models representing trends of associations between continuous variables of TV viewing (relative to 1 hour/day of TV viewing), computer use (relative to 1 hour/day of computer use) and polygenic risk score (relative to a polygenic risk score of 18) and incident coronary heart disease (CHD). Figure S4. Distribution of the calculated polygenic risk score (PRS) for coronary heart disease using 46 SNPs were genome-wide significant at a p-value of 5×10-8 and in low linkage disequilibrium defined according to r2&lt;0.001. Table S1. A list of 300 Single-Nucleotide Polymorphisms (SNPs) known to be associated with coronary heart disease risk. Table S2. Associations of TV viewing and computer use with incident coronary heart disease (CHD) after excluding an additional two years of follow-up. Table S3. Associations of TV viewing and computer use with incident coronary heart disease (CHD) after excluding individuals with poor self-reported health status (i.e. based on the 4-level self-reported health ratings; poor [excluded], fair, good, excellent). Table S4. Associations of TV viewing and computer use with incident coronary heart disease (CHD) after excluding individuals with 2nd-degree genetic relatedness. Table S5. Associations of genetic risk for coronary heart disease and TV viewing and computer use with incident coronary heart disease (CHD) using a weighted polygenic risk score calculated based only on 46 lead SNPs (from 46 loci) which were genome-wide significant at a p-value of 5×10-8 and in low linkage disequilibrium defined according to r2&lt;0.001. Table S6. Associations of TV viewing and computer use with incident coronary heart disease (CHD) using values imputed for the covariates missing, assuming data missing at random. Table S7. Associations of TV viewing and computer use with incident coronary heart disease (CHD) including prevalence of type 2 diabetes and renal dysfunction as potential confounders. Table S8. Associations of TV viewing and computer use with incident coronary heart disease (CHD) excluding body mass index as a potential confounder. Table S9. Associations of TV viewing and computer use with incident coronary heart disease (CHD) using CHD follow-up censored on January 1st, 2020 to account for potential CHD cases not captured due to participants’ fear of visiting clinics during COVID-19. Table S10. Associations of TV viewing and computer use with incident coronary heart disease (CHD) with adjustment for education, household income and occupation as individual-level indicators of socio-economic status as opposed to area-level socio-economic status (Townsend Deprivation Index).