cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ion and water transport in charge-modified graphene nanopores
Creators: name: Qiu, Yinghua
name: Li, Kun
name: Chen, Weiyu
name: Si, Wei
name: Tan, Qiyan
name: Chen, Yunfei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Porous graphene has high mechanical strength and atomic layer thickness, which make it a promising material for material separation and biomolecule sensing. Electrostatic interactions between charges in aqueous solution are a kind of strong long-range interaction which may have great influence on the fluid transport through nanopores. Here, molecular dynamics simulations were conducted to investigate ion and water transport through a 1.05-nm-in-diameter monolayer graphene nanopore with its edge charge-modified. From the results, it is found that the nanopores are selective to counterions when they are charged. As the charge amount increases, the total ionic currents show an increase-decrease profile while the co-ion currents monotonously decrease. The co-ions rejection can reach 75% and 90% when the nanopores are negatively and positively charged, respectively. Cl ions current increases and reaches a plateau, and Na+ current decreases with the charge amount in the systems where they act as counterions. Besides, the charge modification can enhance the water transport through nanopores obviously. This is mainly due to the ion selection of nanopores. Especially, positive charges on the pore edge facilitate the water transport much more than negative charges.
Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021.
Creators: name: Morang'a, Collins M
name: Ngoi, Joyce M
name: Gyamfi, Jones
name: Amuzu, Dominic SY
name: Nuertey, Benjamin D
name: Soglo, Philip M
name: Appiah, Vincent
name: Asante, Ivy A
name: Owusu-Oduro, Paul
name: Armoo, Samuel
name: Adu-Gyasi, Dennis
name: Amoako, Nicholas
name: Oliver-Commey, Joseph
name: Owusu, Michael
name: Sylverken, Augustina
name: Fenteng, Edward D
name: M'cormack, Violette V
name: Tei-Maya, Frederick
name: Quansah, Evelyn B
name: Ayivor-Djanie, Reuben
name: Amoako, Enock K
name: Ogbe, Isaac T
name: Yemi, Bright K
name: Osei-Wusu, Israel
name: Mettle, Deborah NA
name: Saiid, Samirah
name: Tapela, Kesego
name: Dzabeng, Francis
name: Magnussen, Vanessa
name: Quaye, Jerry
name: Opurum, Precious C
name: Carr, Rosina A
name: Ababio, Patrick T
name: Abass, Abdul-Karim
name: Akoriyea, Samuel K
name: Amoako, Emmanuella
name: Kumi-Ansah, Frederick
name: Boakye, Oliver D
name: Mibut, Dam K
name: Odoom, Theophilus
name: Ofori-Boadu, Lawrence
name: Allegye-Cudjoe, Emmanuel
name: Dassah, Sylvester
name: Asoala, Victor
name: Asante, Kwaku P
name: Phillips, Richard O
name: Osei-Atweneboana, Mike Y
name: Gyapong, John O
name: Kuma-Aboagye, Patrick
name: Ampofo, William K
name: Duedu, Kwabena O
name: Ndam, Nicaise T
name: Bediako, Yaw
name: Quashie, Peter K
name: Amenga-Etego, Lucas N
name: Awandare, Gordon A
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Infectious Disease

description: The COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.
Dithen: A Computation-as-a-Service Cloud Platform For Large-Scale Multimedia Processing
Creators: name: Doyle, Joseph
name: Giotsas, Vasileios
name: Anam, Mohammad Ashraful
name: Andreopoulos, Yiannis
Publisher: name: arXiv
Year: 2016
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: We present Dithen, a novel computation-as-a-service (CaaS) cloud platform specifically tailored to the parallel execution of large-scale multimedia tasks. Dithen handles the upload/download of both multimedia data and executable items, the assignment of compute units to multimedia workloads, and the reactive control of the available compute units to minimize the cloud infrastructure cost under deadline-abiding execution. Dithen combines three key properties: (i) the reactive assignment of individual multimedia tasks to available computing units according to availability and predetermined time-to-completion constraints; (ii) optimal resource estimation based on Kalman-filter estimates; (iii) the use of additive increase multiplicative decrease (AIMD) algorithms (famous for being the resource management in the transport control protocol) for the control of the number of units servicing workloads. The deployment of Dithen over Amazon EC2 spot instances is shown to be capable of processing more than 80,000 video transcoding, face detection and image processing tasks (equivalent to the processing of more than 116 GB of compressed data) for less than $1 in billing cost from EC2. Moreover, the proposed AIMD-based control mechanism, in conjunction with the Kalman estimates, is shown to provide for more than 27% reduction in EC2 spot instance cost against methods based on reactive resource estimation. Finally, Dithen is shown to offer a 38% to 500% reduction of the billing cost against the current state-of-the-art in CaaS platforms on Amazon EC2 (Amazon Lambda and Amazon Autoscale). A baseline version of Dithen is currently available at http://www.dithen.com under the "AutoScale" option.
description: to appear in IEEE Transactions on Cloud Computing. arXiv admin note: substantial text overlap with arXiv:1604.04804
Spin readout of trapped electron qubits
Creators: name: Peng, Pai
name: Matthiesen, Clemens
name: Häffner, Hartmut
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose a scheme to read out the spin of a single electron quantum bit in a surface Paul trap using oscillating magnetic field gradients. The readout sequence is composed of cooling, driving, amplification and detection of the electron's motion. We study the scheme in the presence of noise and trap anharmonicities at liquid helium temperatures. An analysis of the the four procedures shows short measurement times ($25~μ$s) and high fidelities ($99.7\%$) are achievable with realistic experimental parameters. Our scheme performs the function of fluorescence detection in ion trapping schemes, highlighting the potential to built all-electric quantum computers based on trapped electron spin qubits.
Generalized Kapchinskij-Vladimirskij Distribution and Beam Matrix for Phase-Space Manipulations of High-Intensity Beams
Creators: name: Chung, Moses
name: Qin, Hong
name: Davidson, Ronald C.
name: Groening, Lars
name: Xiao, Chen
Publisher: name: arXiv
Year: 2016
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: In an uncoupled linear lattice system, the Kapchinskij-Vladimirskij (KV) distribution, formulated on the basis of the single-particle Courant-Snyder (CS) invariants, has served as a fundamental theoretical basis for the analyses of the equilibrium, stability, and transport properties of high-intensity beams for the past several decades. Recent applications of high-intensity beams, however, require beam phase-space manipulations by intentionally introducing strong coupling. In this Letter, we report the full generalization of the KV model by including all of the linear (both external and space-charge) coupling forces, beam energy variations, and arbitrary emittance partition, which all form essential elements for phase-space manipulations. The new generalized KV model yields spatially uniform density profiles and corresponding linear self-field forces as desired. The corresponding matrix envelope equations and beam matrix for the generalized KV model provide important new theoretical tools for the detailed design and analysis of high-intensity beam manipulations, for which previous theoretical models are not easily applicable.
A sub-acute dosing study of saxitoxin and tetrodotoxin mixtures in mice suggests that the current paralytic shellfish toxin regulatory limit is fit for purpose
Creators: name: Finch, Sarah
name: Webb, Nikki
name: Boundy, Michael
name: Harwood, Tim
name: Munday, John S.
name: Sprosen, Jan
name: Somchit, Chanatda
name: Broadhurst, Ric
Publisher: name: AgResearch
Year: 2023
Subjects: Toxicology (incl. clinical toxicology)

description: Paralytic shellfish poisoning is a worldwide problem induced by shellfish contaminated with paralytic shellfish toxins. To protect human health, a regulatory limit for these toxins in shellfish flesh has been adopted by many countries. In a recent study, mice were dosed with saxitoxin and tetrodotoxin mixtures daily for 28 days showing toxicity at low concentrations, which appeared to be at odds with other work. To further investigate this reported toxicity, we dosed groups of mice with saxitoxin and tetrodotoxin mixtures daily for 21 days. In contrast to the previous study, no effects on mouse bodyweight, food consumption, heart rate, blood pressure, grip strength, blood chemistry or hematology were observed. Furthermore, no histological findings were associated with dosing in this trial. The dose rates in this study were 2.6, 3.8 and 4.9 times greater, respectively, than the highest dose of the previous study. As rapid mortality in three out of five mice was observed in the previous study, the deaths are likely to be due to the methodology used rather than the shellfish toxins. To convert animal data to that used in a human risk assessment, a 100-fold safety factor is required. After applying this safety factor, the dose rates used in the current study were 3.5, 5.0 and 6.5 times greater, respectively, than the acute reference dose for each toxin type set by the European Union. Furthermore, it has previously been proposed that tetrodotoxin be included in the paralytic shellfish poisoning suite of toxins. If this were done, the highest dose rate used in this study would be 13 times the acute reference dose. This study suggests that the previous 28-day trial was flawed and that the current paralytic shellfish toxin regulatory limit is fit for purpose. An additional study, feeding mice a diet laced with the test compounds at higher concentrations than those of the current experiment, would be required to comment on whether the current paralytic shellfish toxin regulatory limit should be modified.
Recommendations on TNFα inhibitor biosimilar use in clinical practice: a comparison of European gastroenterology IBD guidance
Creators: name: Meijboom, Rosanne W
name: Barbier, Liese
name: Druedahl, Louise C
name: Sarnola, Kati
name: Tolonen, Hanna M
name: Gardarsdottir, Helga
name: Egberts, Toine C G
name: Giezen, Thijs J
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Professional associations publish guidance advising gastroenterologists on prescribing biosimilars; however, guidelines differ between countries and change over time. This study aimed to map the presence and content of guidance from European gastroenterology associations on TNFα inhibitor biosimilar use and its development over time. Guidelines on biosimilar prescribing from national gastroenterology associations in the European Economic Area (EEA) partnered with the European Crohn’s and Colitis Organization (ECCO) were collected. Treatment guidelines and biosimilar position papers from 2010 to 2022 were included. Data were extracted using a template. 26 of 30 EEA countries have an ECCO-partnered gastroenterology association, of which 14 (53.8%) had national guidelines addressing biosimilars, four (15.4%) followed ECCO’s position, and three (11.6%) had treatment guidelines without mentioning biosimilars. From five countries (19.2%) no guidelines were retrieved. Among 18 countries with guidance, 14 (77.8%) associations endorsed initiating biological treatment with biosimilars, and 13 (72.2%) endorsed transitioning from originator to biosimilar. Nine associations published multiple guidelines over time addressing biosimilars; overall, their positions became more encouraging. The majority of gastroenterology associations endorsed biosimilar use. The lack of (up-to-date) guidelines for some associations indicates an area of improvement to support biosimilar use in clinical practice.
Self-reported efficacy and safety of infliximab and adalimumab biosimilars after non-medical switch in patients with inflammatory bowel disease: results of a multicenter survey
Creators: name: Sarlós, Patrícia
name: Bikar, Alexander
name: Farkas, Nelli
name: Resál, Tamás
name: Szepes, Zoltán
name: Farkas, Klaudia
name: Nagy, Ferenc
name: Vincze, Áron
name: Miheller, Pal
name: Molnár, Tamás
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Few data are available on subjective disease control and perception of adverse events (AEs) during switching from original anti-TNF agents to biosimilars. Hungarian patients with inflammatory bowel disease were interviewed after a mandatory non-medical switch from an infliximab (IFX) originator to a biosimilar GP1111 or from an adalimumab (ADA) originator to a biosimilar GP2017. Drug choice was based on patient’s and physician’s decision. Subjective efficacy was measured using a 10-point scale, and AEs were assessed. Difference in efficacy before and after the switch was compared within and between the drugs. Seventy-three ADA and 106 IFX switching patients were interviewed. Subjective efficacy of IFX biosimilar was rated lower compared to IFX originator (8.72 ± 1.68 vs. 7.77 ± 2.34; p = 0.001). The ADA biosimilar was rated higher than its originator (9.02 ± 1.61 vs. 8.42 ± 1.93; p = 0.017). Patients receiving ADA biosimilar were more satisfied with the new treatment compared to IFX (p = 0.032). The incidence of new AEs was 85% in the ADA and 55% in the IFX group (1.79 vs. 0.93 AEs per patient, respectively, p < 0.001). Subjective efficacy of switching to a biosimilar was proven in case of ADA, while reduced efficacy was experienced with IFX biosimilar. Perception of AEs was high and varied between biosimilars.
Thermodynamics of a Sufficient Small Singly Spinning Kerr-AdS Black Hole
Creators: name: Pourhassan, Behnam
name: Faizal, Mir
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, we will analyze the thermodynamics of a small singly spinning Kerr-AdS black hole. As the black hole will be sufficient small, its temperature will be large and so we can not neglect the effects of thermal fluctuations. We will demonstrate that these thermal fluctuations correct the entropy of singly spinning Kerr-AdS black hole by a logarithmic correction term. We will analyze the implications of the logarithmic correction on other thermodynamic properties of this black hole, and analyze the stability of such a black hole. We will observe that this form of correction becomes important when the size of the black hole is sufficient small. We will also analyze the effect of these thermal fluctuations on the critical phenomena for such a black hole.
description: 21 pages, 11 figures. Accepted for publication in Nucl. Phys. B (NUPHB 13899)
The effect of experimental protocol on the toxicity of saxitoxin in mice
Creators: name: Finch, Sarah
name: Boundy, Michael
name: Webb, Nikki
name: Harwood, Tim
Publisher: name: AgResearch
Year: 2023
Subjects: Toxicology (incl. clinical toxicology)

description: Regulatory limits for toxins in shellfish are required to ensure the health of consumers. However, these limits also impact the profitability of shellfish industries making it critical that they are fit for purpose. Since human toxicity data is rarely available, the setting of regulatory limits is dependent on animal data which can then be extrapolated for use in the assessment of human risk. The dependence on animal data to keep humans safe means that it is critical that the toxicity data used is robust and of high quality. Worldwide, the protocols used in toxicity testing are varied, making it hard to compare results and adding confusion over which results better reflect the true toxicity. In this study, we look at the effect of mouse gender, i.p. dose volume, mouse body weight and feeding protocols (both acute and sub-acute) on the toxicity of saxitoxin. This allowed the effect of different variables used in toxicity testing to be understood and showed that the feeding protocol used in both acute and sub-acute studies greatly influenced the toxicity of saxitoxin in mice. Therefore, the adoption of a standard protocol for the testing of shellfish toxins is recommended.
Analytic Evaluation of Three Different Five-Electron Atomic Integrals Involving Exponentially Correlated Functions of $r_{ij}$ With $r_{ij}$'s Not Forming A Closed Loop
Creators: name: Padhy, Bholanath
Publisher: name: arXiv
Year: 2016
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The simple method outlined in our earlier paper [B.Padhy, Orissa Journal of Physics, vol.19, No.1, p.1, February 2012] has been utilized here for analytic evaluation of three different five-electron atomic integrals with integrands involving products of s Slater-type orbitals and exponentially correlated functions of the form $r_{ij} exp(-λ_{ij} r_{ij})$. Only products of those $r_{ij}$'s which do not form a closed loop by themselves, are considered.
description: 7 pages
Recommendations on TNFα inhibitor biosimilar use in clinical practice: a comparison of European gastroenterology IBD guidance
Creators: name: Meijboom, Rosanne W
name: Barbier, Liese
name: Druedahl, Louise C
name: Sarnola, Kati
name: Tolonen, Hanna M
name: Gardarsdottir, Helga
name: Egberts, Acg
name: Giezen, Thijs J
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Professional associations publish guidance advising gastroenterologists on prescribing biosimilars; however, guidelines differ between countries and change over time. This study aimed to map the presence and content of guidance from European gastroenterology associations on TNFα inhibitor biosimilar use and its development over time. Guidelines on biosimilar prescribing from national gastroenterology associations in the European Economic Area (EEA) partnered with the European Crohn’s and Colitis Organization (ECCO) were collected. Treatment guidelines and biosimilar position papers from 2010 to 2022 were included. Data were extracted using a template. 26 of 30 EEA countries have an ECCO-partnered gastroenterology association, of which 14 (53.8%) had national guidelines addressing biosimilars, four (15.4%) followed ECCO’s position, and three (11.6%) had treatment guidelines without mentioning biosimilars. From five countries (19.2%) no guidelines were retrieved. Among 18 countries with guidance, 14 (77.8%) associations endorsed initiating biological treatment with biosimilars, and 13 (72.2%) endorsed transitioning from originator to biosimilar. Nine associations published multiple guidelines over time addressing biosimilars; overall, their positions became more encouraging. The majority of gastroenterology associations endorsed biosimilar use. The lack of (up-to-date) guidelines for some associations indicates an area of improvement to support biosimilar use in clinical practice.
Influence of attachment on learning in foster care children in low-income to upper-middle income countries: a scoping review protocol
Creators: name: Angula, Tangi
name: De Almeida, Antoinette
name: Drotsky, Lian
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: The proposed scoping review aims to summarize already existing evidence on the relationship between the common attachment style of children living in orphanages and how that influences their learning performance.
Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness.
Creators: name: Pirillo, Chiara
name: Birch, Flora
name: Tissot, Floriane
name: Anton, Sara Gonzalez
name: Haltalli, Myriam
name: Tini, Valentina
name: Kong, Isabella
name: Piot, Cécile
name: Partridge, Ben
name: Pospori, Costandina
name: Keeshan, Karen
name: Santamaria, Salvatore
name: Hawkins, Edwin
name: Falini, Brunangelo
name: Marra, Andrea
name: Duarte, Delfim
name: Lee, Chiu Fan
name: Roberts, Edward
name: Celso, Cristina Lo
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Human Biology & Physiology
Stem Cells
Tumour Biology

description: Acute myeloid leukemia (AML) is a blood cancer of the myeloid lineage. Its prognosis remains poor, highlighting the need for new therapeutic and precision medicine approaches. AML symptoms often include cytopenias, linked to loss of healthy hematopoietic stem and progenitor cells (HSPCs). The mechanisms behind HSPC decline are complex and still poorly understood. Here, intravital microscopy (IVM) of a well-established experimental model of AML allows direct observation of the interactions between healthy and malignant cells in the bone marrow (BM), suggesting that physical dislodgment of healthy cells by AML through damaged vasculature may play an important role. Multiple matrix metalloproteinases (MMPs), known to remodel extracellular matrix remodeling, are expressed by AML cells and the BM microenvironment. We reason MMPs could be involved in cell displacement and vascular leakiness, therefore we evaluate the therapeutic potential of MMP pharmacological inhibition using the broad-spectrum inhibitor prinomastat. IVM analyses of prinomastat-treated mice reveal reduced vascular permeability and healthy cell clusters in circulation, and lower AML infiltration, proliferation and cell migration. Furthermore, treated mice have increased retention of healthy HSPCs in the BM and increased survival following chemotherapy. Analysis of a human AML transcriptomic database reveals widespread MMP deregulation, and human AML cells show susceptibility to MMP inhibition. Overall, our results suggest that MMP inhibition could be a promising complementary therapy to reduce AML growth and limit the loss of HSPC and BM vascular damage caused by MLL-AF9 and possibly other AML subtypes.
Assessment of real-life patient handling experience of AVT02 administered subcutaneously via autoinjector in patients with moderate to severe active rheumatoid arthritis: an open-label, single-arm clinical trial, then an extension phase of AVT02 administered with a prefilled syringe
Creators: name: Damjanov, Nemanja
name: Kirvalidze, Nana
name: Kurashvili, Nana
name: Berti, Fausto
name: Steiger, Matjaz
name: Sobierska, Joanna
name: Guenzi, Eric
name: Otto, Hendrik
name: Sattar, Abid
name: Haliduola, Halimu N.
name: Edwald, Elin
name: Stroissnig, Heimo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: This study investigated the ability of patients, naïve to adalimumab treatment and self-injection with an autoinjector (AI), to successfully self-administer AVT02, an adalimumab biosimilar, using a custom, ergonomic AI (Alvotech hf., Reykjavik, Iceland). This was a single-arm, open-label study, consisting of an 8-week active period and 48-week extension phase. Patients with moderate to severe rheumatoid arthritis (RA) self-administered 40 mg AVT02 subcutaneously via AI in the active period, followed by prefilled syringe in the extension phase. The primary endpoint was the percentage of successful self-injections up to Week 8. Usability and robustness of the AI were evaluated in the active period; safety, efficacy, pharmacokinetic and immunogenicity data were assessed throughout the study. The AI success rate was 100%. No handling events were noted up to Week 8. Both Ctrough measurements and immunogenicity profile were in line with expectations from previous studies, with no unexpected safety signals. This study demonstrated that AVT02-AI can be successfully and reliably used for repeated self-injections of AVT02 by moderate to severe RA patients, despite no previous experience of adalimumab self-administration. The extension phase provides long-term efficacy and safety data for AVT02 in RA. NCT04224194
Dark matter properties implied by gamma ray interstellar emission models
Creators: name: Balázs, Csaba
name: Li, Tong
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We infer dark matter properties from gamma ray residuals extracted using eight different interstellar emission scenarios proposed by the Fermi-LAT Collaboration to explain the Galactic Center gamma ray excess. Adopting the most plausible simplified ansatz, we assume that the dark matter particle is a Majorana fermion interacting with standard fermions via a scalar mediator. Using this theoretical hypothesis and the Fermi residuals we calculate Bayesian evidences, including Fermi-LAT exclusion limits from 15 dwarf spheroidal galaxies as well. Our Bayes factors single out four of the Fermi scenarios as compatible with the simplified dark matter model. In the most preferred scenario the dark matter (mediator) mass is in the 100-500 (1-200) GeV range and its annihilation is dominated by top quark final state. Less preferred but still plausible is annihilation into b\bar{b} and tau^+tau^- final states with an order of magnitude lower dark matter mass. Our conclusion is that the properties of dark matter extracted from gamma ray data are highly sensitive to the modeling of the interstellar emission.
description: 26 pages, 9 figures and 3 tables
GP2017-HCF, a high concentration formulation, demonstrates similar pharmacokinetics, immunogenicity and safety to GP2017, an approved adalimumab biosimilar
Creators: name: von Richter, Oliver
name: O’Reilly, Terry
name: Guerrieri, Davide
name: Fan, Jamie
name: Fey, Constanze
name: Schussler, Steven
name: Furlan, Fabricio
name: Lemke, Lena
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology

description: GP2017 is an adalimumab biosimilar. The objective of this study is to compare the pharmacokinetics (PK) of GP2017 in its approved formulation and GP2017-high concentration formulation (HCF) in a randomized, double-blind, two-arm PK bridging study. Healthy male subjects received a single 40 mg subcutaneous injection of either GP2017-HCF (n = 162) or GP2017 (n = 168). PK, safety, and immunogenicity were assessed over 72 days post-injection. The 90% confidence intervals [CIs] of geometric mean ratios between GP2017-HCF and GP2017 for Cmax, AUC0-inf, AUC0-360 and AUC0-last were within the pre-defined margin of 0.80 to 1.25; thus, PK comparability between GP2017-HCF and GP2017 was demonstrated. Subgroup analysis of PK comparability by anti-drug antibody (ADA) subpopulation showed that the 90% CIs of geometric mean ratios between GP2017-HCF and GP2017 for Cmax, AUC0-inf, AUC0-360 and AUC0-last were within the margin of 0.80 to 1.25 in ADA-positive and ADA-negative subjects. The proportions of subjects with positive ADA responses and with neutralizing antibodies were comparable between the GP2017-HCF and GP2017 groups. GP2017-HCF and GP2017 were well tolerated, and there were no reports of deaths or other serious adverse events. Results show PK comparability between GP2017-HCF and GP2017 and comparable safety and tolerability.
Enhanced Thermoelectric Properties of Dirac Semimetal Cd3As2
Creators: name: Zhou, Tong
name: Zhang, Cheng
name: Zhang, Huisheng
name: Xiu, Faxian
name: Yang, Zhongqin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report an investigation of temperature- and doping-dependent thermoelectric behaviors of topological semimetal Cd3As2. The electrical conductivity, thermal conductivity, Seebeck coefficient, and figure of merit (ZT) are calculated by using Boltzmann transport theory. The calculated thermoelectric properties of the pristine Cd3As2 match well the experimental results. The electron or hole doping, especially the latter, is found improving much the thermoelectric behaviors of the material. The optimum merit ZT of Cd3As2 with electron doping is found to be about 0.5 at T=700 K with n=1x1020 cm-3, much larger than the maximum experimental value obtained for the pristine Cd3As2 (~0.15). For the p-type Cd3As2, the maximal value of the Seebeck coefficient as a function of temperature increases apparently with the increase of the hole doping concentration and its position shifts drastically towards the lower temperature region compared to that of the n-type Cd3As2, leading to the optimum merit ZT of about 0.5 obtained at low temperature of 500K (p=1x1020 cm-3) in the p-type Cd3As2.
description: 16 pages, 4 figures
GP2017-HCF, a high concentration formulation, demonstrates similar pharmacokinetics, immunogenicity and safety to GP2017, an approved adalimumab biosimilar
Creators: name: von Richter, Oliver
name: O’Reilly, Terry
name: Guerrieri, Davide
name: Fan, Jamie
name: Fey, Constanze
name: Schussler, Steven
name: Furlan, Fabricio
name: Lemke, Lena
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology

description: GP2017 is an adalimumab biosimilar. The objective of this study is to compare the pharmacokinetics (PK) of GP2017 in its approved formulation and GP2017-high concentration formulation (HCF) in a randomized, double-blind, two-arm PK bridging study. Healthy male subjects received a single 40 mg subcutaneous injection of either GP2017-HCF (n=162) or GP2017 (n=168). PK, safety, and immunogenicity were assessed over 72 days post-injection. The 90% confidence intervals [CIs] of geometric mean ratios between GP2017-HCF and GP2017 for Cmax, AUC0-inf, AUC0-360 and AUC0-last were within the pre-defined margin of 0.80 to 1.25; thus, PK comparability between GP2017-HCF and GP2017 was demonstrated. Subgroup analysis of PK comparability by anti-drug antibody (ADA) subpopulation showed that the 90% CIs of geometric mean ratios between GP2017-HCF and GP2017 for Cmax, AUC0-inf, AUC0-360 and AUC0-last were within the margin of 0.80 to 1.25 in ADA-positive and ADA-negative subjects. The proportions of subjects with positive ADA responses and with neutralizing antibodies were comparable between the GP2017-HCF and GP2017 groups. GP2017-HCF and GP2017 were well-tolerated, and there were no reports of deaths or other serious adverse events. Results show PK comparability between GP2017-HCF and GP2017 and comparable safety and tolerability.
EUROLAN-21 Slides
Creators: name: Ahmadi, Sina
name: Bosque-Gil, Julia
name: Stellato, Armando
name: Gracia, Jorge
name: Declerck, Thierry
name: Chiarcos, Christian
name: Dojchinovski, Milan
name: Fäth, Christian
name: Ionov, Max
name: Turbati, Andrea
name: Fiorelli, Manuel
Publisher: name: Zenodo
Year: 2021
Subjects: linked data, linguistic linked data, NexusLinguarum, EUROLAN

description: Compilation of the slides presented during the 1st NexusLinguarum training school on "Introduction to Linked Data for Linguistics", supported by the NexusLinguarum CA18209 COST Action, which took place as the 15th edition of EUROLAN from 8 to 12 February 2021 online, virtually hosted by University "Alexandru Ioan Cuza" Iaşi and the Romanian Academy. See http://eurolan.info.uaic.ro/2021/index.html
Magnetooptical Properties of Rydberg Excitons - Center-of-Mass Quantization Approach
Creators: name: Zielińska-Raczyńska, Sylwia
name: Ziemkiewicz, David
name: Czajkowski, Gerard
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We show how to compute the magnetooptical functions (absorption, reflection, and transmission) when Rydberg Exciton-Polaritons appear, including the effect of the coherence between the electron-hole pair and the electromagnetic field, and the polaritonic effect. Using the Real Density Matrix Approach the analytical expressions for magnetooptical functions are obtained and numerical calculations for Cu$_2$0 crystal are performed. The influence of the strength of applied external magnetic field on the resonance displacement of excitonic spectra is discussed. We report a good agreement with recently published experimental data.
description: 26 pages, 10 figures
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City.
Creators: name: Wertheim, Joel O
name: Wang, Jade C
name: Leelawong, Mindy
name: Martin, Darren P
name: Havens, Jennifer L
name: Chowdhury, Moinuddin A
name: Pekar, Jonathan E
name: Amin, Helly
name: Arroyo, Anthony
name: Awandare, Gordon A
name: Chow, Hoi Yan
name: Gonzalez, Edimarlyn
name: Luoma, Elizabeth
name: Morang'a, Collins M
name: Nekrutenko, Anton
name: Shank, Stephen D
name: Silver, Stefan
name: Quashie, Peter K
name: Rakeman, Jennifer L
name: Ruiz, Victoria
name: Torian, Lucia V
name: Vasylyeva, Tetyana I
name: Pond, Sergei L Kosakovsky
name: Hughes, Scott
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Infectious Disease

description: Recombination is an evolutionary process by which many pathogens generate diversity and acquire novel functions. Although a common occurrence during coronavirus replication, detection of recombination is only feasible when genetically distinct viruses contemporaneously infect the same host. Here, we identify an instance of SARS-CoV-2 superinfection, whereby an individual was infected with two distinct viral variants: Alpha (B.1.1.7) and Epsilon (B.1.429). This superinfection was first noted when an Alpha genome sequence failed to exhibit the classic S gene target failure behavior used to track this variant. Full genome sequencing from four independent extracts reveals that Alpha variant alleles comprise around 75% of the genomes, whereas the Epsilon variant alleles comprise around 20% of the sample. Further investigation reveals the presence of numerous recombinant haplotypes spanning the genome, specifically in the spike, nucleocapsid, and ORF 8 coding regions. These findings support the potential for recombination to reshape SARS-CoV-2 genetic diversity.
Stock Market Insider Trading in Continuous Time with Imperfect Dynamic Information
Creators: name: Danilova, Albina
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Finance (q-fin.MF)
subject: Probability (math.PR)
subject: FOS: Economics and business
subject: FOS: Mathematics

description: This paper studies the equilibrium pricing of asset shares in the presence of dynamic private information. The market consists of a risk-neutral informed agent who observes the firm value, noise traders, and competitive market makers who set share prices using the total order flow as a noisy signal of the insider's information. I provide a characterization of all optimal strategies, and prove existence of both Markovian and non Markovian equilibria by deriving closed form solutions for the optimal order process of the informed trader and the optimal pricing rule of the market maker. The consideration of non Markovian equilibrium is relevant since the market maker might decide to re-weight past information after receiving a new signal. Also, I show that a) there is a unique Markovian equilibrium price process which allows the insider to trade undetected, and that b) the presence of an insider increases the market informational efficiency, in particular for times close to dividend payment.
Assessment of real-life patient handling experience of AVT02 administered subcutaneously via autoinjector in patients with moderate to severe active rheumatoid arthritis: An open-label, single-arm clinical trial, then an extension phase of AVT02 administered with a prefilled syringe
Creators: name: Damjanov, Nemanja
name: Kirvalidze, Nana
name: Kurshvilli, Nana
name: Berti, Fausto
name: Steiger, Matjaz
name: Sobierska, Joanna
name: Guenzi, Eric
name: Otto, Hendrik
name: Sattar, Abid
name: Haliduola, Halimu N.
name: Edwald, Elin
name: Stroissnig, Heimo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: This study investigated the ability of patients, naïve to adalimumab treatment and self-injection with an autoinjector (AI), to successfully self-administer AVT02, an adalimumab biosimilar, using a custom, ergonomic AI (Alvotech hf., Reykjavik, Iceland). This was a single-arm, open-label, AI handling study, consisting of an 8-week active period and 48-week extension phase. Patients with moderate to severe rheumatoid arthritis (RA) self-administered 40mg AVT02 subcutaneously via AI in the active period, followed by prefilled syringe in the extension phase. The primary endpoint was the percentage of successful self-injections up to Week 8. Usability and robustness of the AI were evaluated in the active period; safety, efficacy, pharmacokinetic and immunogenicity data were assessed throughout the study. The AI success rate was 100%. No handling events were noted up to Week 8. Both Ctrough measurements and immunogenicity profile were in line with expectations from previous studies, with no unexpected safety signals. This study demonstrated that AVT02-AI can be successfully and reliably used for repeated self-injections of AVT02 by moderate to severe RA patients, despite no previous experience of adalimumab self-administration. The exploratory extension phase provides long-term efficacy and safety data for AVT02 in RA. NCT04224194
Seacrifog H2020 project deliverable
Creators: name: Grieco, Elisa
name: Bombelli, Antonio
name: Adeyemi, Chabi
name: Kebe, Ibourahima
name: Bamba Silla, Mouhamadou
name: Kim, Dong-Gill
name: Beck, Johannes
name: Acosta, Manuel
name: Lorencová, Eliška
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Report on needs and gaps in Africa in terms of data, knowledge and RI with recommendations for a joint EU-Africa Research & STI agenda on GHG observations focusing on land use and land use change under a changing climate
A non-interventional, post-marketing surveillance study evaluating the safety and effectiveness of biosimilar rituximab (CT-P10) during routine clinical practice in the Republic of Korea
Creators: name: Jo, Jae-Cheol
name: Jeon, Youngwoo
name: Kim, DaJung
name: Yang, Deok-Hwan
name: Lee, Won Sik
name: Choi, Yoon Seok
name: Yi, Jun Ho
name: Yoon, Dok Hyun
name: Kong, Jee Hyun
name: Choe, Jung-Yoon
name: Kim, SungHyun
name: Ahn, KeumYoung
name: Park, TaeHong
name: Ju, Hana
name: Kwon, Soonbum
name: Cho, Seok-Goo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Plant Biology

description: CT-P10 was the first licensed rituximab biosimilar. This Korean post-marketing surveillance study evaluated CT-P10 safety and effectiveness in approved indications. This prospective, open-label, observational, phase 4 study collected routine clinical practice data across 27 centers in the Republic of Korea. Patients received their first CT-P10 treatment, per prescribing information, for non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia (CLL), rheumatoid arthritis (RA), granulomatosis with polyangiitis (GPA), or microscopic polyangiitis (MPA) during the surveillance period (16 November 2016–15 November 2020). Safety (including adverse events [AEs] and adverse drug reactions [ADRs]) and disease-specific clinical response (by best overall response [NHL/CLL], Disease Activity Score in 28-joints [RA], or Birmingham Vasculitis Activity Score for Wegener’s Granulomatosis [GPA/MPA]) were assessed for ≤1 year (NHL/CLL) or ≤24 weeks (RA/GPA/MPA). The safety population comprised 677 patients (604 NHL, 16 CLL, 42 RA, 7 GPA, 8 MPA). AEs/ADRs were reported for 68.4%/27.7% (NHL/CLL), 31.0%/14.3% (RA), and 86.7%/13.3% (GPA/MPA) of patients. Serious AEs and unexpected ADRs did not raise new safety signals. Pneumonia was the most frequent serious ADR overall. Positive effectiveness outcomes were observed. Findings were consistent with the known CT-P10/reference rituximab safety profile, with high effectiveness observed in NHL/CLL and RA.
The Role of Dilemma Games as a Mediation Tool between Citizens & Policy Makers for Urban Rooftop Utilization: A Cypriot Case Study
Creators: name: Merry, Anna
name: Kyriakou, M
Publisher: name: Zenodo
Year: 2024

description: This paper presents the role of a games-based activity as mediation tool between citizens and policy

stakeholders in the field of sustainable urban planning and more specifically the reutilization of rooftops

in the fight against climate change. The paper presents a case study methodology demonstrating the

initial results of a pilot case based in Nicosia, Cyprus. The case study is part of a larger research project

entitled ‘GREAT’ (Games Realizing eZective and AZective Transformations).
Adverse event reporting of marketed biosimilar and biological monoclonal antibody cancer treatments in the United States
Creators: name: Xue, Xiangzhong
name: Truong, Bang
name: Qian, Jingjing
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Computational Biology

description: By 8 September 2022, 10 biological monoclonal antibody (mAb) biosimilar products for cancer treatment had been approved and marketed in the United States (US). This study examined adverse event (AE) reporting patterns and disproportionate reporting signals for mAb biosimilars in the US compared to their originator biologics. The US Food and Drug Adverse Event Reporting System database was used to identify AE reports for biological rituximab, bevacizumab, trastuzumab, and their marketed biosimilars. Proportions of patient age, sex and type of reporters of AEs were described for these reports. Reporting odds ratios (RORs) with 95% confidence intervals were calculated to compare reporting disproportionality in serious, death, and specific AEs between mAb biologics/biosimilars (index) and all other drugs. Breslow-Day statistic was used to determine homogeneity in RORs between each mAb biologic–biosimilar pair at p < 0.05. We observed no risk signals of serious or death AE reporting for all three mAb biosimilars. A signal of disproportionate reporting of death was detected between biological and biosimilar bevacizumab (p < 0.05). Our findings support the similarity in signals of disproportionate AE reporting between mAb originator biologics and biosimilars, except for death between biological and biosimilar bevacizumab.
Uncertain programming model for multi-item solid transportation problem
Creators: name: Dalman, Hasan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optimization and Control (math.OC)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 68T37, 62C86, 90C29, 90C70

description: In this paper, an uncertain Multi-objective Multi-item Solid Transportation Problem (MMSTP) based on uncertainty theory is presented. In the model, transportation costs, supplies, demands and conveyances parameters are taken to be uncertain parameters. There are restrictions on some items and conveyances of the model. Therefore, some particular items cannot be transported by some exceptional conveyances. Using the advantage of uncertainty theory, the MMSTP is first converted into an equivalent deterministic MMSTP. By applying convex combination method and minimizing distance function method, the deterministic MMSTP is reduced into single objective programming problems. Thus, both single objective programming problems are solved using Maple 18.02 optimization toolbox. Finally, a numerical example is given to illustrate the performance of the models.
Tunneling in Axion Monodromy
Creators: name: Brown, Jon
name: Cottrell, William
name: Shiu, Gary
name: Soler, Pablo
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Coleman formula for vacuum decay and bubble nucleation has been used to estimate the tunneling rate in models of axion monodromy in recent literature. However, several of Coleman's original assumptions do not hold for such models. Here we derive a new estimate with this in mind using a similar Euclidean procedure. We find that there are significant regions of parameter space for which the tunneling rate in axion monodromy is not well approximated by the Coleman formula. However, there is also a regime relevant to large field inflation in which both estimates parametrically agree. We also briefly comment on the applications of our results to the relaxion scenario.