cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficacy of an IgM preparation in the treatment of patients with sepsis: a double-blind randomized clinical trial in a pediatric intensive care unit
Creators: name: Kola, Ermira
name: Çelaj, Ermela
name: Bakalli, Iliriana
name: Lluka, Robert
name: Kuli-Lito, Gjeorgjina
name: Sallabanda, Sashenka
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: Aim: Additional treatments for sepsis to be administered alongside the standard therapy recommended by the Surviving Sepsis Campaign have recently undergone evaluation. Due to its anti-bacterial, anti-inflammatory and immunomodulatory properties, intravenous polyvalent immunoglobulin M (IgM)–enriched immunoglobulins (IgM preparation) has been investigated as one of these potentially valid adjunctive therapies. The aim of this trial was to assess the efficacy of an IgM preparation as adjuvant therapy in the treatment of pediatric patients with sepsis. Methods: In our study, 78 septic patients admitted to a pediatric intensive care unit (PICU) at the University Hospital Center “Mother Teresa” in Tirana, Albania, were randomized into two groups (intervention and control). All patients were treated according to standard PICU sepsis guidelines. Additionally, patients in the intervention group received the IgM preparation Pentaglobin® while patients in the control group received standard sepsis therapy, but no immunoglobulin administration. Results: The survival rate was higher in the intervention group (87%, N=34) than in the control group (64%, N=25), and this difference was statistically significant (P=0.03). Length of stay (LOS) was also significantly shorter in the intervention group. Conclusion: In this study conducted in Albania, use of an IgM preparation, in addition to standard sepsis therapy, led to a significant increase in the survival rate as well as a significant reduction in LOS compared with placebo, when administered in PICU patients with sepsis.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
The ${\cal N}=4$ Supersymmetric Linear $W_{\infty}[λ]$ Algebra
Creators: name: Ahn, Changhyun
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: From the recently known ${\cal N}=2$ supersymmetric linear $W_{\infty}^{K,K}[λ]$ algebra where $K$ is the dimension of fundamental (or antifundamental) representation of bifundamental $β\, γ$ and $b \, c$ ghost system, we determine its ${\cal N}=4$ supersymmetric enhancement at $K=2$. We construct the ${\cal N}=4$ stress energy tensor, the first ${\cal N}=4$ multiplet and their operator product expansions (OPEs) in terms of above bifundamentals. We show that the OPEs between the first ${\cal N}=4$ multiplet and itself are the same as the corresponding ones in the ${\cal N}=4$ coset $\frac{SU(N+2)}{SU(N)}$ model under the large $(N,k)$ 't Hooft-like limit with fixed $λ_{co} \equiv \frac{(N+1)}{(k+N+2)}$, up to two central terms. The two parameters are related to each other $λ=\frac{1}{2}\, λ_{co}$. We also provide other OPEs by considering the second, the third and the fourth ${\cal N}=4$ multiplets in the ${\cal N}=4$ supersymmetric linear $W_{\infty}[λ]$ algebra.
description: 51 pages; Added pages 24-27 at the end of section 4, added a mathematica notebook and to appear in PRD
Encyonopsis neerlandica Van de Vijver, Verweij, Van der Wal & Mertens
Creators: name: Kennedy, Bryan
name: Buckley, Yvonne
name: Allott, Norman
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Chromista
Ochrophyta
Bacillariophyceae
Cymbellales
Cymbellaceae
Encyonopsis
Encyonopsis neerlandica

description: Encyonopsis neerlandica Van de Vijver, Verweij, Van der Wal & Mertens (Figs 481–510)
 Description: Characterised by relatively large valves for a diatom in the microcephala -complex, lanceolate to broadly lanceolate in outline with convex margins and rostrate to subcapitate apices. Length 13.6–31.6 μm; width 3.0– 4.5 μm; maximum L:W ratio 8.3. Mostly comparable to the type description but populations in Irish lakes also have distinctly capitate rounded apices (Figs 492–494, 505, 509). Larger valves and initial cells may have non-protracted narrowly rounded ends. Striae are parallel or weakly radiate at centre, becoming increasingly radiate towards the poles. Stria density 25–30 dorsally and 24–29 ventrally in 10 μm. Stria density in Irish populations exceed that reported for type material and valves have a higher maximum L:W ratio. Axial area narrow and central area absent, rarely with a single slightly shortened stria at valve centre. Ultrastructural characters are equivalent to that given with the original species description.
 Ecology: E. neerlandica is widespread in peatland catchments in the West of Ireland, occurring in 26 lakes and reaching a maximum relative abundance of 54%. Its ecology is equivalent to that reported by Van de Vijver et al. (2012) and is found in low to moderate alkalinity, near-neutral humic lakes. It is also found in a number of samples from Cronaniv Burn (max. 9.5%), a river in a near-pristine peatland catchment overlying siliceous geology in Co. Donegal and less frequently in the Bundorragha River, a lake outflow in Co. Mayo. Although found in near-pristine reference lakes, it has a maximum abundance at mesotrophic condition, suggesting a sensitivity value of S=2 for lake ecological assessment (Fig. 532).
description: Published as part of Kennedy, Bryan, Buckley, Yvonne & Allott, Norman, 2019, Taxonomy, ecology and analysis of type material of some small Encyonopsis with description of new species in Ireland, pp. 89-128 in Phytotaxa 395 (2) on pages 118-119, DOI: 10.11646/phytotaxa.395.2.5, http://zenodo.org/record/13716561
Manipulation of Majorana Kramers Qubit and its Tolerance in Time-Reversal-Invariant Topological Superconductor
Creators: name: Tanaka, Yuki
name: Sanno, Takumi
name: Mizushima, Takeshi
name: Fujimoto, Satoshi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We investigate non-Abelian statistics of Majorana Kramers pairs (MKPs) in a network system of one-dimensional time-reversal invariant topological superconductors by using numerical simulations of braiding dynamics, and examine the tolerance against various perturbations which may cause decoherence of MKPs. We, first, consider effects of a magnetic field which breaks time-reversal symmetry. In contrast to a naive expectation, the non-Abelian braiding of MKPs is robust against applied magnetic fields provided that the initial and final states of a braiding process are invariant under the combination of a time reversal and a mirror reflection, even when intermediate states break the combined symmetry. Secondly, we investigate the stability of non-Abelian braidings in the case with gate-induced inhomogeneous potentials at junctions between superconducting nanowires, which generally generate a non-Majorana nearly zero-energy Andreeev bound state at the junctions. It is found that the non-Majorana nearly zero-energy states interfere with MKPs, resulting in the failure of non-Abelian braidings, when the length scale of the inhomogeneous potentials is comparable to the coherence length of the superconductors.
description: 11pages, 9 figures
Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer
Creators: name: Huang, Leaf
name: Lin, C. Michael
name: Xiong, Yang
name: Miao, Lei
name: Zhao, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Clinically, combined therapy of cisplatin (CDDP) and metformin is an effective treatment for non-small cell lung cancer (NSCLC). The success is attributed to synergistic effects between the two drugs. Therefore, we hypothesize that co-encapsulation of CDDP and metformin will avoid the prominent toxicity of CDDP while maintaining the synergy between the regimens. CDDP was first conjugated to polyglutamic acid (PGA) to form anionic PGA-CDDP which was electrostatically complexed with the cationic polymeric metformin (polymet). The nano-sized complex was then stabilized with cationic liposomes composed of DOTAP (2, 3-Dioleoyloxy-propyl)-trimethylammonium/Cholesterol/DSPE-PEG-anisamide aminoethyl. Both in vitro and in vivo experiments confirmed the synergy between polymet and CDDP. CDDP delivered with nanoparticles (NPs) exhibited significantly increased tumor accumulation over free CDDP and suppressed tumor growth through apoptosis in NSCLC H460 tumor-bearing mice without nephrotoxicity. The synergistic effect of polymet alongside CDDP demonstrates that polymet-CDDP NPs can activate the AMP-activated protein kinase α (AMPKα) pathway and inhibit mammalian target rapamycin (mTOR) activity to enhance growth suppression. In all, this platform is the first to successfully co-load polymet, a polymeric metformin, and CDDP into the same nanoparticle for successful treatment of NSCLC.
Level of competencies of family physicians from patients’ viewpoint in post-war Kosovo
Creators: name: Bojaj, Gazmend
name: Czabanowska, Katarzyna
name: Skeraj, Fitim
name: Burazeri, Genc
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: Aim: Besides the health professionals’ perspective, it is equally important to assess the perceptions of the users of health care services with regard to abilities, skills and competencies of their family physicians. Our aim was to assess the level of competencies of family physicians from patients’ viewpoint in transitional Kosovo. Methods: A nationwide survey was conducted in Kosovo in 2013, including a representative sample of 1340 primary health care users aged ≥18 years (49% males aged 50.7±18.4 years and 51% females aged 50.4±17.4 years; response rate: 89%). Participants were asked to assess the level of competencies of their respective family physicians regarding different domains of the medical encounter. The self-administered questionnaire included 37 items structured into six domains. Answers for each item of the instrument ranged from one (“novice” physicians) to five (“expert” physicians). An overall summary score related to family physicians’ competencies was calculated for each participant [range: from 37 (minimal competencies) to 185 (maximal competencies)]. Furthermore, demographic and socioeconomic data were collected. General Linear Model was used to assess the demographic and socioeconomic correlates of the overall level of family physicians’ competences according to patients’ perspective. Results: Mean value of the overall summary score for the 37-item instrument was 118.0±19.7. It was higher among the younger and the low-income participants, and in patients who reported frequent health visits and those not satisfied with the quality of the medical encounter. Conversely, no sex, or educational differences were noted. Conclusions: Our findings indicate a relatively high level of competencies of family physicians from patients’ perspective in post-war Kosovo. Future studies should comprehensively assess the main determinants of self-perceived competencies of family physicians among primary health care users in Kosovo.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 2/2019
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: 080

description: Beitragsordnung der Studierendenschaft der Technischen Universität Dortmund vom 16. Januar 2019
description: Amtliche Mitteilungen der Technischen Universität Dortmund;2019,2
Observation of $Z_c(3900)^{0}$ in $e^+e^-\toπ^0π^0 J/ψ$
Creators: name: BESIII Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Using a data sample collected with the BESIII detector operating at the BEPCII storage ring, we observe a new neutral state $Z_c(3900)^{0}$ with a significance of $10.4σ$. The mass and width are measured to be $3894.8\pm2.3\pm3.2$ MeV/$c^2$ and $29.6\pm8.2\pm8.2$~MeV, respectively, where the first error is statistical and the second systematic. The Born cross section for $e^+e^-\toπ^0π^0 J/ψ$ and the fraction of it attributable to $π^0 Z_c(3900)^{0}\toπ^0π^0 J/ψ$ in the range $E_{cm}=4.19-4.42$ GeV are also determined. We interpret this state as the neutral partner of the four-quark candidate $Z_c(3900)^\pm$.
description: 7 pages, 4 figures, submit to Physics Review Letter
Intracellular delivery and ultrasonic activation of folate receptor-targeted phase-change contrast agents in breast cancer cells in vitro
Creators: name: Ingram, Pier
name: Witte, Russell S.
name: Sheeran, Paul S.
name: Marshalek, Joseph P.
name: Dayton, Paul A.
name: Matsunaga, Terry O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Breast cancer is a diverse and complex disease that remains one of the leading causes of death among women. Novel, outside-of-the-box imaging and treatment methods are needed to supplement currently available technologies. In this study, we present evidence for the intracellular delivery and ultrasound-stimulated activation of folate receptor (FR)-targeted phase-change contrast agents (PCCAs) in MDA-MB-231 and MCF-7 breast cancer cells in vitro. PCCAs are lipid-coated, perfluorocarbon-filled particles formulated as nanoscale liquid droplets capable of vaporization into gaseous microbubbles for imaging or therapy. Cells were incubated with 1:1 decafluorobutane (DFB) / octafluoropropane (OFP) PCCAs for 1 hour, imaged via confocal microscopy, exposed to ultrasound (9 MHz, MI = 1.0 or 1.5), and imaged again after insonation. FR-targeted PCCAs were observed intracellularly in both cell lines, but uptake was significantly greater (p < 0.001) in MDA-MB-231 cells (93.0% internalization at MI = 1.0, 79.5% at MI = 1.5) than MCF-7 cells (42.4% internalization at MI = 1.0, 35.7% at MI = 1.5). Folate incorporation increased the frequency of intracellular PCCA detection 45-fold for MDA-MB-231 cells and 7-fold for MCF-7 cells, relative to untargeted PCCAs. Intracellularly activated PCCAs ranged from 500 nm to 6 microns (IQR = 800 nm – 1.5 microns) with a mean diameter of 1.15 ± 0.59 (SD) microns. The work presented herein demonstrates the feasibility of PCCA intracellular delivery and activation using breast cancer cells, illuminating a new platform toward intracellular imaging or therapeutic delivery with ultrasound.
Harvesting energy driven by Comisso-Asenjo process from Kerr-MOG black holes
Creators: name: Khodadi, Mohsen
name: Mota, David F.
name: Sheykhi, Ahmad
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Magnetic reconnection is a process that plays a critical role in plasma astrophysics by converting magnetic energy into plasma particle energy. Recently, Comisso and Asenjo demonstrated that rapid magnetic reconnection within a black hole's ergosphere can efficiently extract energy from a rotating black hole. In this paper, by considering a Kerr black hole in the MOdified gravity (MOG) framework, we investigate the impact of the MOG parameter $α$ on the rotational energy extraction via the Comisso-Asenjo process (CAP). To model energy extraction from supermassive black holes located in the center of galaxies, we set the value of $α$ within the range inferred from the recent observation of Sgr A* by the Event Horizon Telescope (EHT). Our results indicate that the Kerr-MOG black hole is a more efficient host for CAP-based rotational energy extraction compared to the Kerr black hole, since it amplifies the power of energy extraction and efficiency of the plasma energization process. We show that, from the energy extraction viewpoint, the CAP is more efficient than the Blandford-Znajek process (BZP). The latter is another magnetic field-based energy extraction model which is widely believed to be an engine for powering the high-energy astrophysics jets emerging from the supermassive black holes at active galactic nuclei. In particular, we show that the ratio of the energy extraction power of CAP to BZP in the presence of the MOG parameter is greater than that of the Kerr black hole. Our results promise this phenomenological message that the MOG-induced correction on the Kerr black hole background plays an important role in favor of energy extraction via the CAP.
description: 30 pages, 10 figures.v2: version accepted for publication in JCAP: discussion improved, Refs added
Seasonal variations of schizophrenic patients in emergency departments in Sofia, Bulgaria
Creators: name: Spasova, Zornitsa
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: Aim: The purpose of this study was to reveal the seasonal distribution of emergency department visits of schizophrenic patients in Sofia, Bulgaria. Methods: We collected daily data for visits of patients with schizophrenia, schizotypal and delusional disorders in the emergency center of the regional dispenser for mental disorders in the city of Sofia for the period 1998-2003. The total number of emergency visits was 5723 (mean daily visits: 5.04±2.4). T-test was used to compare the monthly and seasonal distribution of visits. Results: The season with the highest levels of emergency visits was summer, and the lowest levels were observed in winter (P<0.0001). Spring and autumn had intermediate values close to the mean value, and significantly differentiated from winter values. The month with the highest admission rates was September, followed by May and the three summer’s months. The lowest levels were observed in December, October and January, with statistically significant differences observed between the values of all the three months. Differences between July values compared with December and October values were significant, but not with January values. Conclusion: The study showed significant seasonal and monthly differences in emergency schizophrenics’ visits. The data confirm the outcome of similar studies conducted in countries with temperate climate in the Northern Hemisphere. These results could prove useful for psychiatrists, public health specialists, and governmental authorities dealing with team planning and prevention programs in the field of psychiatry.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
Nanoparticle-mediated miR200-b delivery for the treatment of diabetic retinopathy
Creators: name: Mitra, Rajendra Narayan
name: Naash, Muna I.
name: Nichols, Chance A.
name: Makkia, Rasha
name: Han, Zongchao
name: Guo, Junjing
name: Cooper, Mark J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We recently reported that the Ins2Akita mouse is a good model for late-onset diabetic retinopathy. Here, we investigated the effect of miR200-b, a potential anti-angiogenic factor, on VEGF receptor 2 (VEGFR-2) expression and to determine the underlying angiogenic response in mouse endothelial cells, and in retinas from aged Ins2Akita mice. MiR200-b and its native flanking sequences were amplified and cloned into a pCAG-eGFP vector directed by the ubiquitous CAG promoter (namely pCAG-miR200-b-IRES-eGFP). The plasmid was compacted by CK30PEG10K into DNA nanoparticles (NPs) for in vivo delivery. Murine endothelial cell line, SVEC4-10, was first transfected with the plasmid. The mRNA levels of VEGF and VEGFR-2 were quantified by qRT-PCR and showed significant reduction in message expression compared with lipofectamine-transfected cells. Transfection of miR200-b suppressed the migration of SVEC4-10 cells. There was a significant inverse correlation between the level of expression of miR200-b and VEGFR-2. Intravitreal injection of miR200-b DNA NPs significantly reduced protein levels of VEGFR-2 as revealed by western blot and markedly suppressed angiogenesis as evaluated by fundus imaging in aged Ins2Akita mice even after 3 months of post-injection. These findings suggest that NP-mediated miR200-b delivery has negatively regulated VEGFR-2 expression in vivo.
Assessment of knowledge, attitudes and practices about public health nutrition among students of the University of Medicine in Tirana, Albania
Creators: name: Hyska, Jolanda
name: Mersini, Ehadu
name: Mone, Iris
name: Bushi, Entela
name: Sadiku, Edite
name: Hoti, Kliti
name: Bregu, Arjan
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: Aim: the aim of this survey was twofold: (i): to assess medical students’ knowledge, attitudes and practices regarding nutrition in general, in order to identify their level of competences in the field of nutrition which will be useful in their future role of providers/health care professionals, and; (ii) to assess the knowledge, attitudes and practices regarding the discipline of public health nutrition in order to identify the needs for improving the curriculum of this subject in all the branches of the University of Medicine in Tirana. Methods: A cross-sectional study was conducted in June-July 2013 including a representative sample of 347 students at the University of Medicine in Tirana, Albania (61% females and 39% males; overall mean age: 23±2 years; response rate: 87%). A nutritional questionnaire, adopted according to the models used in previous international studies, was used to assess the level of knowledge, attitudes and practices among the university students. Results: Overall, about one third of the students was not satisfied with the quality and quantity of nutritional education and demanded a more scientifically rigorous curriculum. In general, students’ knowledge about infant feeding practices was adequate. However, there were gaps in the students’ knowledge regarding the commencement of breastfeeding, or the duration of exclusive breast-feeding. Furthermore, there was evidence of an insufficient level of knowledge among students regarding diet and nutrition in general and their health impact, especially on development and prevention of chronic diseases. Conclusion: This survey identified significant gaps in the current curriculum of public health nutrition at the University of Medicine in Tirana. Our findings suggest the need for intervention programs to improve both the quantitative and the qualitative aspects of nutrition curricula in all the branches of the University of Medicine Tirana, in accordance with the professional expectations of this teaching institution, as well as the urge for a movement towards a more integrated curriculum and problem-based learning approach.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
Neglect, abuse and violence against older women: Definitions and research frameworks
Creators: name: Brownell, Patricia
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: The aging of the global population with women living longer than men, resulting in the feminization of aging, focuses attention on the intersection of gender and age. Women across the lifespan can be victims of violence but there has been little attention to date to the neglect, abuse and violence against older women. Because of this gap in knowledge and remedies, little is known about neglect, abuse and violence against older women, particularly its prevalence as well as evidence-based prevention and intervention strategies. Several definitions of neglect, abuse and violence are reviewed here, along with conceptual frameworks that operationalize these definitions differently, resulting in differences in findings on prevalence as well as fragmentation in the way that older women victims of abuse are viewed. Three definitions of older adult abuse are discussed, including those formulated by the Toronto Declaration, the National Research Council, and the United States Center for Disease Control. Each focuses on a different aspect of abuse of older women: active ageing, old age dependency, and domestic violence in later life. A fourth conceptual framework, the human rights perspective, shows promise for addressing abuse of older women in a more holistic manner than the other definitions, but Is not fully developed as a way of understanding neglect, abuse and violence against older women. This is the first of a four-part series on older women and abuse.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
Quadrupole moments and their interactions in the triangular lattice antiferromagnet FeI$_2$
Creators: name: Chen, Gang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Motivated by the recent experiments on the triangular lattice antiferromagnet FeI$_2$, we consider the presence of the quadrupole moments and their interactions between the spin-orbital-entangled local moments. In addition to the anisotropic pairwise interaction between the local moments, the interaction between the quadrupole moment arises from the interaction of the orbital occupation configurations. This is argued primarily from the time reversal symmetry and the different orbital configurations via their exchange paths. We discuss the implication of these interactions and expect this result to be complementary to the existing works in this system and other systems alike.
description: to appear in Phys Rev Res Lett
Comparing thin accretion disk properties of naked singularities and black holes
Creators: name: Tahelyani, Divya
name: Joshi, Ashok B.
name: Dey, Dipanjan
name: Joshi, Pankaj S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In the present paper, we study the thermal properties of the geometrically thin accretion disks surrounding the null naked singularity (NNS) and the first type of Joshi-Malafarina-Narayan (JMN1) spacetimes and compare the results with the accretion disk around equally massive Schwarzschild black hole. First, we examine the properties of the circular orbits in these spacetimes. The emitted flux, radiation spectra, disk efficiency, and temperature distribution on the disk surface are then investigated. The efficiency of the conversion of the accreting matter into radiation is found to be substantially higher for naked singularities than that for black holes. We also verify that the flux radiated from the disk surface is greater for null and JMN1 naked singularities than black holes. Hence, the accretion disks around naked singularities are much more luminous than the black holes of the same mass and accretion rate. In the luminosity spectra of the NNS, we find that the significant contribution of the low-frequency is coming from the nearby regions of the NNS. Furthermore, the spectral luminosity distribution for the "non-zero torque" at the inner boundary is also analysed by the inclusion of the non-zero torque value at the inner edge of the disk. The slopes of the luminosity distribution with respect to frequency for naked singularity spacetimes differ significantly from those of black holes. These unique features of the naked singularities serve as an effective tool to distinguish them from the equally massive black holes.
description: 16 pages, 20 figures
Methane storage in nanoporous media as observed via high field NMR relaxometry
Creators: name: Papaioannou, Antonios
name: Kausik, Ravinath
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geophysics (physics.geo-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The storage properties of methane gas in Vycor porous glass (5.7 nm) are characterized in a wide pressure range from 0.7 MPa-89.7 MPa using Nuclear Magnetic Resonance (NMR). We demonstrate the capability of high field NMR relaxometry for the determination of the methane gas storage capacity and the measurement of the Hydrogen Index, to a high degree of accuracy. This helps determine the excess gas in the pore space which can be identified to exhibit Langmuir properties in the low pressure regime of 0.7 MPa to 39.6 Mpa. The Langmuir model enables us to determine the equilibrium density of the monolayer of adsorbed gas to be 8.5% lower than that of liquid methane. We also identify the signatures of multilayer adsorption at the high pressure regime from 39.6 Mpa to 89.7 Mpa and use the Brunauer-Emmet-Teller (BET) theory to determine the number of adsorbed layers of methane gas. We show how these measurements help us differentiate the gas stored in the Vycor pore space into free and adsorbed fractions for the entire pressure range paving way for similar applications such as studying natural gas storage in gas shale rock or hydrogen storage in carbon nanotubes.
description: 11 pages, 12 Figures
34 Briefe, 1 Beilage an Leonhard Meister
Brief an Meister ...
Creators: name: Hirzel, Hans Caspar
Publisher: name: [s.n.]
Year: 1796

description: von [Hans Caspar] Hirzel
description: Beilage: 1 Notiz zu Hans Caspar Hirzels Publikation "Das Bild eines wahren Patrioten" von Leonhard Meister, dat. Küssnacht 1768 (Nr. 169)
A practical and applied approach to assessing the cross cutting nature of child injury prevention as a basis for policy making at the local level
Creators: name: Scholtes, Beatrice
name: Schröder-Bäck, Peter
name: Mackay, Morag
name: Vincenten, Joanne
name: Brand, Helmut
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: Aim: Risk factors for child injury are multi-faceted. Social, environmental and economic factors place responsibility for prevention upon many stakeholders across traditional sectors such as health, justice, environment and education. Multi-sectoral collaboration for injury prevention is thus essential. In addition, co-benefits due to injury prevention initiatives exist. However, multi-sectoral collaboration is often difficult to establish and maintain. We present an applied approach for practitioners and policy makers at the local level to use to explore and address the multi-sectoral nature of child injury. Methods: We combined elements of the Haddon Matrix and the Lens and Telescope model, to develop a new approach for practitioners and policy makers at the local level. Results: The approach offers the opportunity for diverse sectors at the local level to work together to identify their role in child injury prevention. Based on ecological injury prevention and life-course epidemiology it encourages multi-disciplinary team building from the outset. The process has three phases: first, visualising the multi-sectoral responsibilities for child injury prevention in the local area; second, demonstrating the need for multi-sectoral collaboration and helping plan prevention activities together; and third, visualising potential co-benefits to other sectors and age groups that may arise from child injury prevention initiatives. Conclusion: The approach and process encourages inter-sectoral collaboration for child injury prevention at the local level. It is a useful addition for child injury prevention at the local level, however testing the practicality of the approach in a real-world setting, and refinement of the process would improve it further.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
Nonlinear seismic imaging via reduced order model backprojection
Creators: name: Mamonov, Alexander V.
name: Druskin, Vladimir
name: Zaslavsky, Mikhail
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N21

description: We introduce a novel nonlinear seismic imaging method based on model order reduction. The reduced order model (ROM) is an orthogonal projection of the wave equation propagator operator on the subspace of the snapshots of the solutions of the wave equation. It can be computed entirely from the knowledge of the measured time domain seismic data. The image is a backprojection of the ROM using the subspace basis for the known smooth kinematic velocity model. The implicit orthogonalization of solution snapshots is a nonlinear procedure that differentiates our approach from the conventional linear methods (Kirchhoff, RTM). It allows for the removal of multiple reflection artifacts. It also enables us to estimate the magnitude of the reflectors similarly to the true amplitude migration algorithms.
description: 5 pages, 3 figures, submitted to SEG New Orleans 2015 Annual Meeting
Public health in Kosovo after five difficult years of independence
Creators: name: Jerliu, Naim
name: Ramadani, Naser
name: Mone, Iris
name: Brand, Helmut
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: Kosovo is undergoing a rapid process of transformation to an independent state, which was formally proclaimed in 2008, after almost a decade under United Nations administration. Regarding the health status, five years after independence, compared with other European countries, post-war transitional Kosovo is still characterized by higher mortality rates including traditional public health problems pertinent to infant mortality and maternal deaths. In parallel, however, Kosovo is undergoing a rapid process of epidemiological transition characterized by an aging trend which is inevitably coupled with high cardiovascular and cancer mortality and morbidity along with an excess mortality in external causes of death and injuries among the adult population. Adoption of the new Health Law in December 2012 by the Kosovo Assembly aims the transition from centralized health care system established under emergency conditions of the post-war period towards a contemporary modern health care system with a clear purchaser-provider split based on a high transparency and accountability of the health care providers and their contractors. The health care reform, leading eventually to significant changes within the health sector in Kosovo, consists of two main pillars: (i) structural and functional reorganization of the health care system through establishment of Kosovo Health Service (an autonomous and non-for-profit public enterprise at central level of the health care sector), and; (ii) establishment for the first time of the public health insurance system with a Health Insurance Fund as its main body. Nevertheless, five years after declaration of independence, Kosovo, the newest state in Europe consisting of the youngest population, is currently facing a particularly difficult socioeconomic and political transition and is additionally struggling and mainstreaming all energies and efforts in order to get full international recognition.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
MDI-QKD: Continuous- versus discrete-variables at metropolitan distances
Creators: name: Pirandola, Stefano
name: Ottaviani, Carlo
name: Spedalieri, Gaetana
name: Weedbrook, Christian
name: Braunstein, Samuel L.
name: Lloyd, Seth
name: Gehring, Tobias
name: Jacobsen, Christian S.
name: Andersen, Ulrik L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In a comment, Xu, Curty, Qi, Qian, and Lo claimed that discrete-variable (DV) measurement device independent (MDI) quantum key distribution (QKD) would compete with its continuous-variable (CV) counterpart at metropolitan distances. Actually, Xu et al.'s analysis supports exactly the opposite by showing that the experimental rate of our CV protocol (achieved with practical room-temperature devices) remains one order of magnitude higher than their purely-numerical and over-optimistic extrapolation for qubits, based on nearly-ideal parameters and cryogenic detectors (unsuitable solutions for a realistic metropolitan network, which is expected to run on cheap room-temperature devices, potentially even mobile). The experimental rate of our protocol (expressed as bits per relay use) is confirmed to be two-three orders of magnitude higher than the rate of any realistic simulation of practical DV-MDI-QKD over short-medium distances. Of course this does not mean that DV-MDI-QKD networks should not be investigated or built, but increasing their rate is a non-trivial practical problem clearly beyond the analysis of Xu et al. Finally, in order to clarify the facts, we also refute a series of incorrect arguments against CV-MDI-QKD and, more generally, CV-QKD, which were made by Xu et al. with the goal of supporting their thesis.
description: Updated reply to Xu, Curty, Qi, Qian and Lo (arXiv:1506.04819), including a point-to-point rebuttal of their new "Appendix E: Addendum"
Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease: Cochrane systematic review protocol
Creators: name: Dyakova, Mariana
name: Drew, Christian
name: Wright, Nicola
name: Clarke, Aileen
name: Rees, Karen
Publisher: name: South Eastern European Journal of Public Health (SEEJPH)
Year: 2015

description: A large number of people, considered at increased risk of vascular disease, remain unidentified, untreated and not reached by lifestyle advice or intervention, despite public health and clinical efforts. This has prompted the initiation of national screening/systematic risk assessment programmes for vascular disease in healthy populations. These exist in addition to the more ad hoc opportunistic risk assessment initiatives undertaken worldwide. There is currently not enough indisputable evidence either showing clear clinical or economic benefits of systematic screening-like programmes over opportunistic risk assessment of cardiovascular disease (CVD) in primary care. We present the rationale and methodology of a Cochrane systematic review, assessing the effectiveness, costs and adverse effects of systematic risk assessment compared to opportunistic risk assessment for the primary prevention of CVD.
description: South Eastern European Journal of Public Health (SEEJPH), Volume I, 2014
Derivative interactions and perturbative UV contributions in N Higgs Doublet Models
Creators: name: Kikuta, Yohei
name: Yamamoto, Yasuhiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the Higgs derivative interactions on models including arbitrary number of the Higgs doublets. These interactions are generated by two ways. One is higher order corrections of composite Higgs models, and the other is integrating out heavy scalars and vectors. In the latter case, three point couplings between the Higgs doublets and them are the sources of the derivative interactions. The representations of these heavy particles are constrained to couple with the doublets. We explicitly calculate the all derivative interactions generated by integrating out. Their degrees of freedom and conditions to impose the custodial symmetry are discussed. We also study the vector boson scattering processes with a couple of two Higgs doublet models to see experimental signals of the derivative interactions. They are differently affected by each heavy field.
description: 7501 words, finite figures, non zero tables; published version
The forward-backward asymmetry in the electron positron annihilation process at twist-4
Creators: name: Yang, W.
name: Li, C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A quantity of particular experimental interest is the forward-backward asymmetry in the angular distribution of positively and negatively charged fermions produced in $Z^0$ decays. Measurements of this asymmetry can enable independent determinations of the neutral-current couplings of these fermions, i.e. the $Z^0$ boson couplings for left- and right-handed fermions, respectively. Due to the quark confinement, however, it is difficult to determine the electroweak interactions of quarks, especially for light quarks. In the hadron production electron positron annihilation process, the parton model with factorization theorem gives a reliable approximate description. Quantities are thus expressed in terms of fragmentation functions in the annihilation process. In this paper, we consider the vector meson production in the inclusive electron positron annihilation process and calculate the forward-backward asymmetry in the hadronic level. Calculations are carried out by applying the collinear expansion in the parton model at leading order twist-4. We note here this process provides not only a tool for analyzing the hadronic weak interactions but also an opportunity for understanding the parton model of the strong interaction. In other words, the results can be used to test the electroweak and strong interactions simultaneously.
Encyonopsis subminuta Krammer & Reichardt (Krammer 1997
Creators: name: Kennedy, Bryan
name: Buckley, Yvonne
name: Allott, Norman
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Chromista
Ochrophyta
Bacillariophyceae
Cymbellales
Cymbellaceae
Encyonopsis
Encyonopsis subminuta

description: Encyonopsis subminuta Krammer & Reichardt (Figs 511–529)
Description: Valves are symmetric or appear only very slightly dorsiventral, lanceolate with weakly convex dorsal and ventral sides. Valve apices are clearly protracted capitate to subcapitate, rarely rostrate and without clear shoulders. Axial area is narrow linear and central area absent. Length 10–25 μm; width 3.0–4.5 μm; maximum L:W ratio 5.8. Striae parallel to weakly radiate at centre, weakly radiate towards apices and uniform in appearance. The upper range of stria density in Irish populations is slightly higher than reported elsewhere (Table 1) and a form with distinct peanut-shaped puncta (Figs 528–529) was also well represented and co-occurs with nominate valves (Figs 523–527). Raphe is filiform, proximal ends curve dorsally with slightly dilated endings. Distal fissure deflected ventrally, terminating in a small pore on the valve face.
Ecology: A cosmopolitan species in well buffered alkaline lakes with low nutrient concentration (Fig. 532). It occurs in 30 lakes with a maximum relative abundance of 25%.
description: Published as part of Kennedy, Bryan, Buckley, Yvonne & Allott, Norman, 2019, Taxonomy, ecology and analysis of type material of some small Encyonopsis with description of new species in Ireland, pp. 89-128 in Phytotaxa 395 (2) on pages 119-120, DOI: 10.11646/phytotaxa.395.2.5, http://zenodo.org/record/13716561
Viscosity and diffusion in life processes and tuning of fundamental constants
Creators: name: Trachenko, K
Publisher: name: arXiv
Year: 2023
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Viewed as one of the grandest questions in modern science, understanding fundamental physical constants has been discussed in high-energy particle physics, astronomy and cosmology. Here, I review how condensed matter and liquid physics gives new insights into fundamental constants and their tuning. This is based on two observations: first, cellular life and the existence of observers depend on viscosity and diffusion. Second, the lower bound on viscosity and upper bound on diffusion are set by fundamental constants, and I briefly review this result and related recent developments in liquid physics. I will subsequently show that bounds on viscosity, diffusion and the newly introduced fundamental velocity gradient in a biochemical machine can all be varied while keeping the fine-structure constant and the proton-to-electron mass ratio intact. This implies that it is possible to produce heavy elements in stars but have a viscous planet where all liquids have very high viscosity (for example that of tar or higher) and where life may not exist. Knowing the range of bio-friendly viscosity and diffusion, we will be able to calculate the range of fundamental constants which favor cellular life and observers and compare this tuning with that discussed in high-energy physics previously. This invites an inter-disciplinary research between condensed matter physics and life sciences, and I formulate several questions that life science can address. I finish with a conjecture of multiple tuning and an evolutionary mechanism.
Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment
Creators: name: Xu, Ying
name: Huo, Meirong
name: Huang, Leaf
name: Zhao, Yan
name: Wang, Yuhua
name: Satterlee, Andrew Benson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Development of an effective treatment against advanced tumors remains a major challenge for cancer immunotherapy. We have previously developed a potent mannose-modified lipid calcium phosphate (LCP) nanoparticle (NP)-based Trp2 vaccine for melanoma therapy, but because this vaccine can induce a potent anti-tumor immune response only during the early stages of melanoma, poor tumor growth inhibition has been observed in more advanced melanoma models, likely due to the development of an immune-suppressive tumor microenvironment (TME). To effectively treat this aggressive tumor, a multi-target receptor tyrosine kinase inhibitor, sunitinib base, was efficiently encapsulated into a targeted polymeric micelle nano-delivery system (SUNb-PM), working in a synergistic manner with vaccine therapy in an advanced mouse melanoma model. SUNb-PM not only increased cytotoxic T-cell infiltration and decreased the number and percentage of MDSCs and Tregs in the TME, but also induced a shift in cytokine expression from Th2 to Th1 type while remodeling the tumor-associated fibroblasts, collagen, and blood vessels in the tumor. Additionally, inhibition of the Stat3 and AKT signaling pathways by SUNb-PM may induce tumor cell apoptosis or decrease tumor immune evasion. Our findings indicated that targeted delivery of a tyrosine kinase inhibitor to tumors can be used in a novel synergistic way to enhance the therapeutic efficacy of existing immune-based therapies for advanced melanoma.