cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Life cycle assessment and feasibility study of small wind power in Thailand
Creators: name: Kamens, Richard
name: Glassbrook, Keith
name: Carr, Adam
name: Drosnes, Mark
name: Gheewala, Shabbir
name: Oakley, T. Reade
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Thai government’s implementation of its 10 year renewable energy plan was done to help increase energy independence and reduce emissions resulting from energy production. Due to Thailand’s wind regime, wind turbines which can operate in low wind speeds will be needed to meet this goal. Small wind turbines typically operate at higher efficiency in lower winds, and thus they might prove to be a good option for wind power production in Thailand. Incorporating small wind turbines into power production can be difficult because of the perception of high investment costs and because their net benefit has not been adequately studied. Using a functional unit of producing 50 kWh per month for 10 years we conducted a Life Cycle Assessment comparing the global warming potential (GWP), embodied energy (EE), and levelized cost of electricity (LCOE) of four small wind turbines (≤20 kW), a diesel generator, and the Thai Grid. When analyzing GWP of the turbines it was found that they had a lower overall GWP than the diesel generator when in areas with reasonable wind resources. The same is true for embodied energy. Interestingly, in most available wind speed categories in Thailand the LCOE for wind turbines was lower than for the diesel generator. However, neither could compare to the LCOE of the Thai Grid, except in the areas with the highest average wind speeds (7.0 -­‐9.4 m/s). With this in mind, it is clear that the most important factor when considering wind power generation is the wind regime available in an area. Because of the increased cost relative to the Thai grid, implementation of wind turbines in Thailand was not found to be economically viable. This could be changed given lower costs for turbines and/or government incentives.
Inequalities on stellar rotational splittings derived from assumptions on the rotation profile
Creators: name: Reese, D. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context: A number of pulsating stars with rotational splittings have been observed thanks to the CoRoT and Kepler missions. This is particularly true of evolved (sub-giant and giant) stars, and has led various groups to investigate their rotation profiles via different methods. Aims: We would like to set up some criteria which will help us to know whether a decreasing rotation profile, or one which satisfies Rayleigh's stability criterion, is compatible with a set of observed rotational splittings for a given reference model. Methods: We derive inequalities on the rotational splittings using a reformulated version of the equation which relates the splittings to the rotation profile and kernels. Results: These inequalities are tested out on some simple examples. The first examples show how they are able to reveal when a rotation profile is increasing somewhere or inconsistent with Rayleigh's criterion in a main sequence star, depending on the profile and the $\ell$ values of the splittings. The next example illustrates how a slight mismatch between an observed evolved star and a reference model can lead to erroneous conclusions about the rotation profile. We also show how frequency differences between the star and the model, which should normally reveal this mismatch, can be masked by frequency corrections for near-surface effects.
description: 15 pages, 19 figures, accepted for publication in A&A
Appendix 2: in silico (B) vs in vivo 3D distance plots aligned in the Frankfort plane from Modelling human skull growth: a validated computational model.
Creators: name: Libby, Joseph
name: Arsalan Marghoub
name: Johnson, David
name: Khonsari, Roman H.
name: Fagan, Michael J.
name: Moazen, Mehran
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biological Engineering
subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: n silico (B) vs. in vivo 3D distance plots – Frankfort plane alignment: The scaling polarity used here was the same as that used in Figure 6. The blue areas on the plots highlight where the in silico (B) model under-predicted the in vivo CT data and the red areas indicate where the in silico (B) skull over-predicted the geometry of the in vivo CT data. Each skull has been scaled individually with the max and min values for the colour chart displayed below each age.
Prediction of Potential Commercially Available Inhibitors against SARS-CoV-2 by Multi-Task Deep Learning Model
Creators: name: Hu, Fan
name: Jiang, Jiaxin
name: Yin, Peng
Publisher: name: arXiv
Year: 2020
Subjects: subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: The outbreak of COVID-19 caused millions of deaths worldwide, and the number of total infections is still rising. It is necessary to identify some potentially effective drugs that can be used to prevent the development of severe symptoms or even death for those infected. Fortunately, many efforts have been made, and several effective drugs have been identified. The rapidly increasing amount of data is of great help for training an effective and specific deep learning model. In this study, we propose a multi-task deep learning model for the purpose of screening commercially available and effective inhibitors against SARS-CoV-2. First, we pretrained a model on several heterogenous protein-ligand interaction datasets. The model achieved competitive results on some benchmark datasets. Next, a coronavirus-specific dataset was collected and used to fine-tune the model. Then, the fine-tuned model was used to select commercially available drugs against SARS-CoV-2 protein targets. Overall, twenty compounds were listed as potential inhibitors. We further explored the model interpretability and observed the predicted important binding sites. Based on this prediction, molecular docking was also performed to visualize the binding modes of the selected inhibitors.
title: Education to the recognition of the equal right to freedom of all people with Betzavta – the Method of the Adam Institute. Evaluation of the role of the facilitation for the effect of the method
Creators: name: Klahn, Marett Katalin
Publisher: name: Europa-Universität Viadrina Frankfurt
Year: 2020

description: The present thesis deals with the role of the facilitation in the work with Betzavta – the Method of the Adam Institute that was developed by Dr. Uki Maroshek-Klarman at the Adam Institute for Democracy and Peace (Israel). The objective of the democracy education method is the education to the active recognition of the equal right to freedom of all people. In order to attain said objective, a specific educational process is designed that is based on the work with democratic dilemmas and the increase of complexity when looking at political issues. The awareness about the complexity as well as the recognition of the equal right to freedom of all people should enable participants to find sustainable solutions for societal conflicts and deficiencies that benefit all and disadvantaged social groups in particular. The pedagogical process addresses the cognitive as well as the experiential dimension and refers to the level of individuals as well as (sub-)groups, in the seminar group and in the entire society. A specific way of facilitation is needed for the design of such educational processes and for their intended effect. This facilitation is in the focus of the thesis. In order to examine how the way of facilitation relates to possible effects of the method, a multi-day seminar was evaluated within the frame of a case study and by use of qualitative methods. Several interviews with the developer as well as her writings constitute the central standard of comparison of the evaluation.
[PDF] HAY MAS CUERNOS EN UN BUENAS NOCHES descargar gratis
Creators: name: Noland
Publisher: name: Zenodo
Year: 2024

description: HAY MAS CUERNOS EN UN BUENAS NOCHES de MANUEL JABOIS

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Ficha técnica

HAY MAS CUERNOS EN UN BUENAS NOCHES

MANUEL JABOIS

Número de páginas: 416

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788418998089

Editorial: PEPITAS DE CALABAZA

Año de edición: 2022

 

 

 

 

 

Descarga libros gratis para ipods HAY MAS CUERNOS EN UN BUENAS NOCHES (Literatura española) de MANUEL JABOIS

 

Overview

Hay más cuernos en un buenas noches, que además de la historia de los últimos diez años contiene diez años de historias, reúne los textos breves más destacados de Manuel Jabois desde la publicación de Irse a Madrid (Pepitas, 2011). Un tiempo en el que Manu ha pasado, con la tranquilidad con la que se desenvuelve un gato, a convertirse en uno de los escritores más leídos en español. Autor pop como pocos, Jabois es capaz de invertir la perspectiva sobre la minucia más trascendental, de someter en su columna una noticia hasta sacarle luz, de encogerte el corazón cuando habla de sus amigos o matarte de risa con la anécdota más inquietante. Acercándose siempre a la realidad con una mirada limpia, en este gozoso volumen —la certificación de que estamos ante una de las voces más propias y originales que ha dado nuestra literatura reciente— brilla en todo su esplendor.
c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Pol  recruitment to stalled replication forks
Creators: name: Masai, Hisao
name: Gurkar, Aditi
name: Li, Jianying
name: Kakusho, Naoko
name: Vaziri, Cyrus
name: Durando, Michael
name: Barkley, Laura R.
name: Day, Tovah A.
name: Palle, Komaraiah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The association of Rad18 with Polη is crucial for efficient translesion synthesis and DNA damage tolerance. Rad18–Polη interactions and UV tolerance depend on JNK-dependent Rad18 phosphorylation. These results provide a new mechanism by which SAPK signaling promotes genome maintenance.The E3 ubiquitin ligase Rad18 chaperones DNA polymerase η (Polη) to sites of UV-induced DNA damage and monoubiquitinates proliferating cell nuclear antigen (PCNA), facilitating engagement of Polη with stalled replication forks and promoting translesion synthesis (TLS). It is unclear how Rad18 activities are coordinated with other elements of the DNA damage response. We show here that Ser-409 residing in the Polη-binding motif of Rad18 is phosphorylated in a checkpoint kinase 1–dependent manner in genotoxin-treated cells. Recombinant Rad18 was phosphorylated specifically at S409 by c-Jun N-terminal kinase (JNK) in vitro. In UV-treated cells, Rad18 S409 phosphorylation was inhibited by a pharmacological JNK inhibitor. Conversely, ectopic expression of JNK and its upstream kinase mitogen-activated protein kinase kinase 4 led to DNA damage–independent Rad18 S409 phosphorylation. These results identify Rad18 as a novel JNK substrate. A Rad18 mutant harboring a Ser → Ala substitution at S409 was compromised for Polη association and did not redistribute Polη to nuclear foci or promote Polη−PCNA interaction efficiently relative to wild-type Rad18. Rad18 S409A also failed to fully complement the UV sensitivity of Rad18-depleted cells. Taken together, these results show that Rad18 phosphorylation by JNK represents a novel mechanism for promoting TLS and DNA damage tolerance.
Download Pdf La pratique de l'Oracle Belline
Creators: name: Redding
Publisher: name: Zenodo
Year: 2024

description: La pratique de l'Oracle Belline pan Corinne Morel

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Caractéristiques

La pratique de l'Oracle Belline

Corinne Morel

Nb. de pages: 219

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782850908712

Editeur: Bussière

Date de parution: 2023

 

 

 

Ebooks gratuits à télécharger gratuitement La pratique de l'Oracle Belline (French Edition) 9782850908712

 

Overview

Parmi les jeux les plus couramment utilisés par les voyants, on trouve bien sûr le Tarot de Marseille, mais également l'Oracle Belline. En effet, ce jeu divinatoire, vieux de plusieurs siècles et à la symbolique très riche, se distingue par la justesse de ses prédictions. Il a comme particularité d'analyser les situations passées, présentes et avenir, de rendre visible ce qui était invisible, et de donner à chacun une clé, permettant de redevenir maître de son existence. Ce livre est le guide idéal pour tous ceux qui désirent connaître et utiliser ce jeu. Il contient de nombreux conseils relatifs à l'interprétation, à la gestion de la relation et à la guidance d'une consultation complète. Chaque carte est définie selon les plans affectifs, professionnels, financiers, physiques et psychologiques. De nombreux tirages sont présentés, accompagnés à chaque fois d'études de cas et de corrigés précis. Le lecteur peut ainsi véritablement s'entraîner et accéder à une excellente maîtrise de l'Oracle Belline, connu pour sa précision et sa fiabilité.
Radical uncertainty: scenario planning for futures
Creators: name: Zapata, Marisa
name: Kaza, Nikhil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The use of scenario planning in urban and regional planning practice has grown in the last decade as one way to face uncertainty. However, in adapting scenario planning from its origins in the business sector, planners have eliminated two key components: 1) the use of multiple scenarios, and 2) the inclusion of diverse organizations, people and interests through deep deliberations. We argue that this shift limits the ability for planners to plan for multiple plausible and futures that are shaped by an increasing number of diverse actors. In this paper, we use case study research to examine how uncertainty was considered in four scenario planning processes. We analyzed and compared the cases based on analytical categories related to multiple futures and diversity. We found that the processes that used multiple, structurally distinct scenarios explored a wider range of topics and issues shaping places. All four relied heavily on professional stakeholders as the scenario developers, limiting public input. Only one of those processes that included multiple futures captured the differential effects that scenarios would have on diverse people and interests. All in all, the purpose of the scenario planning drove the participant diversity and ultimately the quality and use of the scenarios.
(3353) Henry Peter Crofts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Embedding non-arithmetic hyperbolic manifolds
Creators: name: Kolpakov, Alexander
name: Riolo, Stefano
name: Slavich, Leone
Publisher: name: arXiv
Year: 2020
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: This paper shows that many hyperbolic manifolds obtained by glueing arithmetic pieces embed into higher-dimensional hyperbolic manifolds as codimension-one totally geodesic submanifolds. As a consequence, many Gromov--Pyatetski-Shapiro and Agol--Belolipetsky--Thomson non-arithmetic manifolds embed geodesically. Moreover, we show that the number of commensurability classes of hyperbolic manifolds with a representative of volume $\leq v$ that bounds geometrically is at least $v^{Cv}$, for $v$ large enough.
description: 20 pages, 5 figures. Final version
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity
Creators: name: Elston, Timothy C.
name: Dohlman, Henrik G.
name: Errede, Beverly
name: Parnell, Stephen C.
name: Hao, Nan
name: Nagiec, Michal J.
name: Yildirim, Necmettin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A series of mathematical models was used to quantitatively characterize pheromone-stimulated kinase activation and determine how mitogen-activated protein (MAP) kinase specificity is achieved. The findings reveal how feedback phosphorylation of a common pathway component can limit the activity of a competing MAP kinase through feedback phosphorylation of a common activator, and thereby promote signal fidelity.Different environmental stimuli often use the same set of signaling proteins to achieve very different physiological outcomes. The mating and invasive growth pathways in yeast each employ a mitogen-activated protein (MAP) kinase cascade that includes Ste20, Ste11, and Ste7. Whereas proper mating requires Ste7 activation of the MAP kinase Fus3, invasive growth requires activation of the alternate MAP kinase Kss1. To determine how MAP kinase specificity is achieved, we used a series of mathematical models to quantitatively characterize pheromone-stimulated kinase activation. In accordance with the computational analysis, MAP kinase feedback phosphorylation of Ste7 results in diminished activation of Kss1, but not Fus3. These findings reveal how feedback phosphorylation of a common pathway component can limit the activity of a competing MAP kinase through feedback phosphorylation of a common activator, and thereby promote signal fidelity.
Appendix 2: in silico (B) vs in vivo 3D distance plots aligned in the Frankfort plane from Modelling human skull growth: a validated computational model
Creators: name: Libby, Joseph
name: Arsalan Marghoub
name: Johnson, David
name: Khonsari, Roman H.
name: Fagan, Michael J.
name: Moazen, Mehran
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biological Engineering
subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: n silico (B) vs. in vivo 3D distance plots – Frankfort plane alignment: The scaling polarity used here was the same as that used in Figure 6. The blue areas on the plots highlight where the in silico (B) model under-predicted the in vivo CT data and the red areas indicate where the in silico (B) skull over-predicted the geometry of the in vivo CT data. Each skull has been scaled individually with the max and min values for the colour chart displayed below each age.
Descargar PDF ADIVINA QUIEN SOY
Creators: name: Mejia
Publisher: name: Zenodo
Year: 2024

description: ADIVINA QUIEN SOY de MEGAN MAXWELL

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Ficha técnica

ADIVINA QUIEN SOY

MEGAN MAXWELL

Número de páginas: 448

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408153771

Editorial: PLANETA

Año de edición: 2016

 

 

 

 

 

Descargar libros electrónicos libros de google ADIVINA QUIEN SOY de MEGAN MAXWELL DJVU (Spanish Edition) 9788408153771

 

Overview

Llega la saga erótica más esperada. Altamente adictivaYanira trabaja de cantante en los hoteles de Tenerife. Está soltera y vive rodeada de su familia. Su vida es plácida y, en cierto modo, acomodada.Pero a Yanira le gusta experimentar cosas nuevas, y decide adentrarse en el mundo de los intercambios de pareja. En uno de los bares que frecuenta conoce a un italiano que le enseñará que el sexo va mucho más allá de lo que ella conocía hasta el momento. Un año más tarde se traslada a Barcelona y comienza a trabajar de camarera en un crucero de vacaciones llamado Espíritu Santo. En el barco también está Dylan, un atractivo empleado de la sección de mantenimiento que apenas le hace caso, a pesar de las continuas sonrisas de Yanira. Lo que ella no sabe es que la observa más de lo que cree, y aunque los malentendidos que surgen entre ellos le hacen pensar lo contrario, la atracción que sienten les hará encontrarse y compartir un sinfín de juegos morbosos, divertidos y sensuales. Adivina quién soy es una divertida comedia erótica en la que las sonrisas brotarán a raudales de tu boca y donde tú misma te sentirás en la piel de la protagonista.
(3351) Charles Guerin Crofts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Giving Stated Preference Respondents “Time to Think”: Results From Four Countries
Creators: name: Jeuland, Marc
name: Whittington, Dale
name: Maskery, Brian
name: Cook, Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Previous studies have found that contingent valuation (CV) respondents who are given overnight to reflect on a CV scenario have 30 - 40% lower average willingness-to-pay (WTP) than respondents who are interviewed in a single session. This “time to think” (TTT) effect could explain much of the gap between real and hypothetical WTP observed in experimental studies. Yet giving time to think is still rare in binary or multinomial discrete choice studies. We review the literature on increasing survey respondents’ opportunities to reflect on their answers and synthesize results from parallel TTT studies on private vaccine demand in four countries. Across all four countries, we find robust and consistent evidence from both raw data and multivariate models for a TTT effect: giving respondents overnight to think reduced the probability that a respondent said he or she would buy the hypothetical vaccines. Average WTP fell approximately 40%. Respondents with time to think were also more certain of their answers, and a majority said they used the opportunity to consult with their spouse or family. We conclude with a discussion of why researchers might be hesitant to adopt the TTT methodology.
Multiple scaling limits of $\mathrm{U}(N)^2 \times \mathrm{O}(D)$ multi-matrix models
Creators: name: Benedetti, Dario
name: Carrozza, Sylvain
name: Toriumi, Reiko
name: Valette, Guillaume
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study the double- and triple-scaling limits of a complex multi-matrix model, with $\mathrm{U}(N)^2\times \mathrm{O}(D)$ symmetry. The double-scaling limit amounts to taking simultaneously the large-$N$ (matrix size) and large-$D$ (number of matrices) limits while keeping the ratio $N/\sqrt{D}=M$ fixed. The triple-scaling limit consists in taking the large-$M$ limit while tuning the coupling constant $λ$ to its critical value $λ_c$ and keeping fixed the product $M(λ_c-λ)^α$, for some value of $α$ that depends on the particular combinatorial restrictions imposed on the model. Our first main result is the complete recursive characterization of the Feynman graphs of arbitrary genus which survive in the double-scaling limit. Next, we classify all the dominant graphs in the triple-scaling limit, which we find to have a plane binary tree structure with decorations. Their critical behavior belongs to the universality class of branched polymers. Lastly, we classify all the dominant graphs in the triple-scaling limit under the restriction to three-edge connected (or two-particle irreducible) graphs. Their critical behavior falls in the universality class of Liouville quantum gravity (or, in other words, the Brownian sphere).
description: 55 pages, 33 figures; v2: minor corrections; v3: matches journal version, to appear in Ann. Inst. Henri Poincar\'e D
POLÍTICA
Creators: name: Miller
Publisher: name: Zenodo
Year: 2024

description: POLÍTICA EBOOK de ARISTÓTELES

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Ficha técnica

POLÍTICA EBOOK

ARISTÓTELES

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 8596547800910

Editorial: GOOD PRESS

 

 

 

 

 

Ebook ipad descargar gratis POLÍTICA EBOOK 8596547800910 de ARISTÓTELES CHM

 

Overview

Este ebook presenta "Política", con un índice dinámico y detallado. Política reúne los escritos que Aristóteles dedicó a la vida en sociedad y la organización de la convivencia cívica. Una suma de tratados menores de sorprendente riqueza de temas, expuestos con la agudeza y profundidad que caracteriza el pensamiento aristotélico. El discípulo de Platón comienza analizando las estructuras básicas de la sociedad, en la que la ciudad representa el logro más cabal: el hombre está definido como un ser cívico y por encima de la familia, la tribu y la aldea se perfila la polis como el ámbito autosuficiente de la cultura y la vida feliz. Tras pasar revista a los distintos tipos de gobierno, se muestra partidario de la democracia moderada, la clase media, el equilibrio de poderes y una constitución mixta. Señala después los rasgos que definen al ciudadano en su participación en la tareas comunitarias, e insiste en la importancia de la educación para mantener y mejorar esa vida digna y libre. Aristóteles (384 a. C. - 322 a. C.) fue un polímata: filósofo, lógico y científico de la Antigua Grecia cuyas ideas han ejercido una enorme influencia sobre la historia intelectual de Occidente por más de dos milenios.
(3346) Ewen Neville Crofts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Calibrated photoacoustic spectrometer based on a conventional imaging system for in vitro characterization of contrast agents
Creators: name: Lucas, Théotim
name: Sarkar, Mitradeep
name: Atlas, Yoann
name: Linger, Clément
name: Renault, Gilles
name: Gazeau, Florence
name: Gateau, Jérôme
Publisher: name: arXiv
Year: 2020
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Photoacoustic (PA) imaging systems are spreading in the biomedical community, and the de-velopment of new PA contrast agents is an active area of research. However, PA contrast agents are usually characterized with spectrophotometry or uncalibrated PA imaging systems, leading to partial assessment of their PA efficiency. To enable quantitative PA spectroscopy of contrast agents in vitro with conventional PA imaging systems, we have developed an adapted calibration method. Contrast agents in solution are injected in a dedicated non-scattering tube phantom imaged at different optical wavelengths. The calibration method uses a reference solu-tion of cupric sulfate to simultaneously correct for the spectral energy distribution of excitation light at the tube location and perform a conversion of the tube amplitude in the image from ar-bitrary to spectroscopic units. The method does not require any precise alignment and provides quantitative PA spectra, even with non-uniform illumination and ultrasound sensitivity. It was implemented on a conventional imaging setup based on a tunable laser operating between 680 nm and 980 nm and a 5 MHz clinical ultrasound array. We demonstrated robust calibrated PA spectroscopy with sample volumes as low as 15 μL of known chromophores and commonly used contrast agents. The validated method will be an essential and accessible tool for the de-velopment of new and efficient PA contrast agents by improving their quantitative characterization.
description: 20 pages, 10 figures
The actin-microtubule cross-linking activity of Drosophila Short stop is regulated by intramolecular inhibition
Creators: name: Duncan, Mara C.
name: Applewhite, Derek A.
name: Grode, Kyle D.
name: Rogers, Stephen L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Actin and microtubule dynamics must be precisely coordinated during cell migration, mitosis, and morphogenesis—much of this coordination is mediated by proteins that physically bridge the two cytoskeletal networks. We have investigated the regulation of the Drosophila actin-microtubule cross-linker Short stop (Shot), a member of the spectraplakin family. Our data suggest that Shot's cytoskeletal cross-linking activity is regulated by an intramolecular inhibitory mechanism. In its inactive conformation, Shot adopts a “closed” conformation through interactions between its NH2-terminal actin-binding domain and COOH-terminal EF-hand-GAS2 domain. This inactive conformation is targeted to the growing microtubule plus end by EB1. On activation, Shot binds along the microtubule through its COOH-terminal GAS2 domain and binds to actin with its NH2-terminal tandem CH domains. We propose that this mechanism allows Shot to rapidly cross-link dynamic microtubules in response to localized activating signals at the cell cortex.
(3348) Joan Mary Crofts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DOWNLOAD [PDF] {EPUB} Coeur du Sahel
Creators: name: Hughes
Publisher: name: Zenodo
Year: 2024

description: Coeur du Sahel pan Djaïli Amadou Amal

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Caractéristiques

Coeur du Sahel

Djaïli Amadou Amal

Nb. de pages: 285

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782290376973

Editeur: J'ai lu

Date de parution: 2023

 

 

 

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Overview

Faydé habite un village au coeur des montagnes, dans l'extrême nord du Cameroun. Une vie suspendue à la sécheresse et aux assauts de Boko Haram, à laquelle elle rêve d'échapper. Alors que sa famille peine à se nourrir, l'adolescente décide de partir à Maroua, la ville la plus proche, où elle sera domestique. Comme ses comparses, elle devra se faire à sa nouvelle condition, citadine et difficile. Mais, malgré le mépris de classe, les mauvais traitements et la violence des hommes, elle y découvrira aussi l'amitié, la littérature, l'espoir... Dans une société où son destin semble tracé d'avance, Faydé parviendra-t-elle à se frayer un chemin vers la liberté ? A travers la vie non plus des "Impatientes" mais de leurs domestiques, Djaïli Amadou Amal signe un roman bouleversant et réaffirme, plus fort que jamais, son engagement contre les injustices faites aux femmes.
Small Weight Code Words of Projective Geometric Codes
Creators: name: Adriaensen, Sam
name: Denaux, Lins
Publisher: name: arXiv
Year: 2020
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05B25, 94B05

description: We investigate small weight code words of the $p$-ary linear code $\mathcal C_{j,k}(n,q)$ generated by the incidence matrix of $k$-spaces and $j$-spaces of PG$(n,q)$ and its dual, with $q$ a prime power and $0 \leq j < k < n$. Firstly, we prove that all code words of $\mathcal C_{j,k}(n,q)$ up to weight $\left(3 - \mathcal{O}\left(\frac 1 q \right) \right) \genfrac{[}{]}{0pt}{}{k+1}{j+1}_q$ are linear combinations of at most two $k$-spaces (i.e. two rows of the incidence matrix). As for the dual code $\mathcal C_{j,k}(n,q)^\perp$, we manage to reduce both problems of determining its minimum weight (1) and characterising its minimum weight code words (2) to the case $\mathcal C_{0,1}(n,q)^\perp$. This implies the solution to both problem (1) and (2) if $q$ is prime and the solution to problem (1) if $q$ is even.
description: 26 pages, 1 figure
A Dexterous Tip-extending Robot with Variable-length Shape-locking
Creators: name: Wang, Sicheng
name: Zhang, Ruotong
name: Haggerty, David A.
name: Naclerio, Nicholas D.
name: Hawkes, Elliot W.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Soft, tip-extending "vine" robots offer a unique mode of inspection and manipulation in highly constrained environments. For practicality, it is desirable that the distal end of the robot can be manipulated freely, while the body remains stationary. However, in previous vine robots, either the shape of the body was fixed after growth with no ability to manipulate the distal end, or the whole body moved together with the tip. Here, we present a concept for shape-locking that enables a vine robot to move only its distal tip, while the body is locked in place. This is achieved using two inextensible, pressurized, tip-extending, chambers that "grow" along the sides of the robot body, preserving curvature in the section where they have been deployed. The length of the locked and free sections can be varied by controlling the extension and retraction of these chambers. We present models describing this shape-locking mechanism and workspace of the robot in both free and constrained environments. We experimentally validate these models, showing an increased dexterous workspace compared to previous vine robots. Our shape-locking concept allows improved performance for vine robots, advancing the field of soft robotics for inspection and manipulation in highly constrained environments.
description: 7 pages,10 figures. Accepted to IEEE International Conference on Rootics and Automation (ICRA) 2020
The spatial segregation of pericentric cohesin and condensin in the mitotic spindle
Creators: name: Taylor II, Russell M.
name: Chang, Binny
name: Stephens, Andrew D.
name: Haase, Julian
name: Bloom, Kerry
name: Quammen, Cory W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The mitotic chromatin spring is organized into a rosette of intramolecular loops of pericentric chromatin by condensin and cohesin. Model convolution reveals that condensin clusters along the spindle axis, while cohesin is dispersed radially along pericentromere loops.In mitosis, the pericentromere is organized into a spring composed of cohesin, condensin, and a rosette of intramolecular chromatin loops. Cohesin and condensin are enriched in the pericentromere, with spatially distinct patterns of localization. Using model convolution of computer simulations, we deduce the mechanistic consequences of their spatial segregation. Condensin lies proximal to the spindle axis, whereas cohesin is radially displaced from condensin and the interpolar microtubules. The histone deacetylase Sir2 is responsible for the axial position of condensin, while the radial displacement of chromatin loops dictates the position of cohesin. The heterogeneity in distribution of condensin is most accurately modeled by clusters along the spindle axis. In contrast, cohesin is evenly distributed (barrel of 500-nm width × 550-nm length). Models of cohesin gradients that decay from the centromere or sister cohesin axis, as previously suggested, do not match experimental images. The fine structures of cohesin and condensin deduced with subpixel localization accuracy reveal critical features of how these complexes mold pericentric chromatin into a functional spring.
Spatio-temporal models for large-scale indicators of extreme weather
Creators: name: Katzfuss, Matthias
name: Ramachandar, Shahla
name: Heaton, Matthew
name: Pedings, Kathryn
name: Gilleland, Eric
name: Mannshardt-Shamseldin, Elizabeth
name: Smith, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The changing global climate has sparked an interest in how these changes are affecting the intensity and frequency of extreme weather events such as thunderstorms and tornadoes because these extreme events pose a significant threat to life, property, and economic stability. This article uses and evaluates several spatio-temporal statistical extreme value models to model extreme weather from reanalysis data observed across the continental United States and Mexico. The models find that the intensity of extreme weather is particularly high for the central United States. Additionally, the intensity of extreme weather is increasing over time but the amount of increase may not be practically significant.
Download PDF Serve by C. W. Farnsworth
Creators: name: Herrera
Publisher: name: Zenodo
Year: 2024

description: Serve by C. W. Farnsworth

 

 

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Serve

C. W. Farnsworth

Page: 312

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Publisher: Barnes & Noble Press

 

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Overview

Georgette Adams is trouble incarnate. Spoiled, sassy, smart...and the President's only daughter. Getting summoned to a meeting at the White House felt like an honor—until I caught the catch. I'm the newest member of her security detail. Not only for this summer in DC, but once she leaves for Stanford in the fall as well. Her safety is my responsibility. Trouble is, the only place Georgie respects any rules is on the tennis court. Our priorities clash and our personalities conflict, yet somehow—the more time we spend together, the less it feels like work. But my job description doesn't include making her laugh or enjoying our conversations. And it definitely doesn't involve broken rules or blurred lines. My only job? Is to serve.
(3349) Charles Daniel Crofts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Microscopic Analysis of the Uplink Interference in FDMA Small Cell Networks
Creators: name: Ding, Ming
name: Lopez-Perez, David
name: Mao, Guoqiang
name: Lin, Zihuai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we analytically derive an upper bound on the error in approximating the uplink (UL) single-cell interference by a lognormal distribution in frequency division multiple access (FDMA) small cell networks (SCNs). Such an upper bound is measured by the Kolmogorov Smirnov (KS) distance between the actual cumulative density function (CDF) and the approximate CDF. The lognormal approximation is important because it allows tractable network performance analysis. Our results are more general than the existing works in the sense that we do not pose any requirement on (i) the shape and/or size of cell coverage areas, (ii) the uniformity of user equipment (UE) distribution, and (iii) the type of multi-path fading. Based on our results, we propose a new framework to directly and analytically investigate a complex network with practical deployment of multiple BSs placed at irregular locations, using a power lognormal approximation of the aggregate UL interference. The proposed network performance analysis is particularly useful for the 5th generation (5G) systems with general cell deployment and UE distribution.
description: Final IEEE version: http://ieeexplore.ieee.org/document/7426421/. arXiv admin note: text overlap with arXiv:1505.01924
FastDTW is approximate and Generally Slower than the Algorithm it Approximates
Creators: name: Wu, Renjie
name: Keogh, Eamonn J.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Many time series data mining problems can be solved with repeated use of distance measure. Examples of such tasks include similarity search, clustering, classification, anomaly detection and segmentation. For over two decades it has been known that the Dynamic Time Warping (DTW) distance measure is the best measure to use for most tasks, in most domains. Because the classic DTW algorithm has quadratic time complexity, many ideas have been introduced to reduce its amortized time, or to quickly approximate it. One of the most cited approximate approaches is FastDTW. The FastDTW algorithm has well over a thousand citations and has been explicitly used in several hundred research efforts. In this work, we make a surprising claim. In any realistic data mining application, the approximate FastDTW is much slower than the exact DTW. This fact clearly has implications for the community that uses this algorithm: allowing it to address much larger datasets, get exact results, and do so in less time.
description: Full paper accepted by IEEE TKDE, extended abstract accepted by IEEE ICDE 2021
TGF-  regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion
Creators: name: Osborne, Lukas D.
name: O'Brien, E. Tim
name: Blobe, Gerard C.
name: Mythreye, Karthikeyan
name: Li, George Z.
name: Superfine, Richard
name: How, Tam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recent studies implicate a role for cell mechanics in cancer progression. Transforming growth factor β–induced epithelial-to-mesenchymal transition results in decreased stiffness and loss of the normal stiffening response to force applied on integrins.Recent studies implicate a role for cell mechanics in cancer progression. The epithelial-to-mesenchymal transition (EMT) regulates the detachment of cancer cells from the epithelium and facilitates their invasion into stromal tissue. Although classic EMT hallmarks include loss of cell–cell adhesions, morphology changes, and increased invasion capacity, little is known about the associated mechanical changes. Previously, force application on integrins has been shown to initiate cytoskeletal rearrangements that result in increased cell stiffness and a stiffening response. Here we demonstrate that transforming growth factor β (TGF-β)–induced EMT results in decreased stiffness and loss of the normal stiffening response to force applied on integrins. We find that suppression of the RhoA guanine nucleotide exchange factors (GEFs) LARG and GEF-H1 through TGF-β/ALK5–enhanced proteasomal degradation mediates these changes in cell mechanics and affects EMT-associated invasion. Taken together, our results reveal a functional connection between attenuated stiffness and stiffening response and the increased invasion capacity acquired after TGF-β–induced EMT.
CURRENT URGENT ISSUES IN GREEN ECONOMY
Creators: name: Abdujalilova, Oyzoda
Publisher: name: Zenodo
Year: 2025

description: This article analyzes the current pressing issues of the green economy. It examines the effectiveness of the green economy as an economic model aimed at environmental protection, ensuring economic stability, and enhancing social welfare. The article discusses issues such as climate change, the transition to renewable energy sources, resource management, the development of green technologies and innovations. It also highlights the challenges in transitioning to a green economy and the importance of global cooperation in this process. The role of government policy, economic support, and the promotion of innovation in the transition to a green economy is emphasized. This article helps understand the contemporary trends in green economy and reviews strategies put forward to ensure ecological sustainability.
(3345) Peter Ewan Le P Crofts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dynamical properties of the Pascal adic transformation
Creators: name: PETERSEN, KARL
name: MÉLA, XAVIER
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We study the dynamics of a transformation that acts on infinite paths in the graph associated with Pascal’s triangle. For each ergodic invariant measure the asymptotic law of the return time to cylinders is given by a step function. We construct a representation of the system by a subshift on a two-symbol alphabet and then prove that the complexity function of this subshift is asymptotic to a cubic, the frequencies of occurrence of blocks behave in a regular manner, and the subshift is topologically weak mixing.