cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comparing Various Approaches to Simulating the Formation of Shell Galaxies
Creators: name: Ebrova, Ivana
name: Bartoskova, Katerina
name: Jungwiert, Bruno
name: Jilkova, Lucie
name: Krizek, Miroslav
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The model of a radial minor merger proposed by Quinn (1984), which successfully reproduces the observed regular shell systems in shell galaxies, is ideal for a test-particle simulation. We compare such a simulation with a self-consistent one. They agree very well in positions of the first generation of shells but potentially important effects -- dynamical friction and gradual decay of the dwarf galaxy -- are not present in the test-particle model, therefore we look for a proper way to include them.
description: 2 pages, 1 figure, to appear in the Proceedings of JENAM 2010, Symposium 2: "Environment and the formation of galaxies: 30 years later"
INGLIZ TILINI O`RGANISHDA LEKSIK KO`NIKMALARNING AHAMIYATI
Creators: name: Farmonova, Naimaxon
Publisher: name: Zenodo
Year: 2025

description: Hozirgi rivojlangan davrda ta`lim jarayonida turli interaktiv metodlar, pedagogik va axborot texnologiyalarini o`quv jarayoniga qo`llashga bo`lgan e`tibor va ehtiyoj kundan-kunga ortib bormoqda.Ayniqsa, chet tilini o`rganishga bo`lgan ehtiyoj zamon rivojlangani, yangi texnologiyalarning kirib kelishi va ularni amalda qo`llash zarurati sababli oshib bormoqda. Ta`lim sohasida amalga oshirilayotgan islohotlar yoshlarning chet tilini yanada samarali va sifatli o`rganishiga zamin yaratib bermoqda. Shu o`rinda chet tilini o`qitish, ta`limda turli metod va texnologiyalarni qo`llash zamon talabiga aylanmoqda.  Ingliz tili dunyo miqyosida eng ko`p o`rganiladigan tillar qatorida birinchi o`rinni egallaydi va bizning yurtimizda ham bu tilni o`rganish kundan-kunga ommalshib bormoqda.
Nonminimal curvature-matter coupled wormholes with matter satisfying the null energy condition
Creators: name: Garcia, Nadiezhda Montelongo
name: Lobo, Francisco S. N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, exact solutions of wormhole geometries supported by a nonminimal curvature-matter coupling were found, where the nonminimal coupling minimizes the violation of the null energy condition of normal matter at the throat. In this brief report, we present a solution where normal matter satisfies the energy conditions at the throat and it is the higher order curvature derivatives of the nonminimal coupling that is responsible for the null energy condition violation, and consequently for supporting the respective wormhole geometries. For simplicity, we consider a linear R nonmiminal curvature-matter coupling and an explicit monotonically increasing function for the energy density. Thus, the solution found is not asymptotically flat, but may in principle be matched to an exterior vacuum solution.
description: 4 pages, 7 figures
Additional file 3 of Clinical researchers’ lived experiences with data quality monitoring in clinical trials: a qualitative study
Creators: name: Houston, Lauren
name: Yu, Ping
name: Martin, Allison
name: Probst, Yasmine
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3. Interview Questions.
The targum (1875:Oct.)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1875

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Additional file 1 of Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery
Creators: name: Katsuda, Yosuke
name: Tanaka, Kenichi
name: Mori, Tomohisa
name: Narita, Michiko
name: Takeshima, Hideyuki
name: Kondo, Takashige
name: Yamabe, Yoshiyuki
name: Matsufuji, Misa
name: Sato, Daisuke
name: Hamada, Yusuke
name: Yamaguchi, Keisuke
name: Ushijima, Toshikazu
name: Inada, Eiichi
name: Kuzumaki, Naoko
name: Iseki, Masako
name: Narita, Minoru
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. Details of RT-qPCR primer.
Tidal Warping of Be Star Decretion Discs
Creators: name: Martin, Rebecca G.
name: Pringle, J. E.
name: Tout, Christopher A.
name: Lubow, Stephen H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Rapidly rotating Be stars are observed as shell stars when the decretion disc is viewed edge on. Transitions between the two implies that the discs may be warped and precessing. Type II X-ray outbursts are thought to occur when the warped disc interacts with the fast stellar wind. We suggest that tides from a misaligned companion neutron star can cause the observed effects. We make numerical models of a Be star decretion disc in which the spin of the Be star is misaligned with the orbital axis of a neutron star companion. Tidal torques from the neutron star truncate the disc at a radius small enough that the neutron star orbit does not intersect the disc unless the eccentricity or misalignment is very large. A magnetic torque from the Be star that is largest at the equator, where the rotation is fastest, is approximated by an inner boundary condition. There are large oscillations in the mass and inclination of the disc as it moves towards a steady state. These large variations may explain the observed changes from Be star to Be shell star and vice-versa and also the Type II X-ray outbursts. We find the tidal timescale on which the disc warps, precesses and reaches a steady state to be around a year up to a few hundred years. If present, the oscillations in mass and disc inclination occur on a fraction of this timescale depending on the orbital parameters of the binary. The timescales associated with the tidal torque for observed Be star binaries suggest that these effects are important in all but the longest period binaries.
description: Accepted for publication in MNRAS
Strategies to manage forest carbon in British Columbia.
Creators: name: Man, Cosmin D.
Publisher: name: University of British Columbia
Year: 2015

description: This research uses the inventory of 3 actively managed forest estates located in the Coast, Southern Interior, and Northern Interior forest regions in British Columbia. The performance of two groups of forest management strategies (harvest reduction and increased growth rate strategies) is explored in order to determine the carbon storage potential. A sensitivity analysis is conducted for the strategy that reduces the harvest to a fixed target level to determine the cost to produce carbon credits. A new method is developed to reduce the cost to produce carbon credits through implementing fluctuating harvest schedules that allow the target harvest to fluctuate between a minimum accepted level and the baseline level. The results confirmed that at forest estate level, harvest reduction strategies outperform by a significant margin the increased growth rate strategies. There were no differences in terms of carbon storage and age class distribution between the various harvest reduction strategies analyzed in this study (fixed target harvest level, increased minimum harvest ages, and 2 strategies to increase area in reserves). Thus, the strategy that reduces the harvest to a fixed target level is preferred because it provides more flexibility in addressing natural disturbances and market fluctuations. The cost to produce carbon credits ranged from $3.9 to $40.8 tCO₂e-¹ (at 0% discount rate), out of which, the opportunity cost of reducing harvest represented 58%-97%. It was demonstrated that the inclusion of the opportunity cost of reducing harvest dominated the cost to produce carbon credits which, contrary to previous findings, increased with increasing forest productivity expressed both, as site index (i.e., top height in m at age 50) and average value of harvested timber (in $ ha-¹). The new method that implements fluctuating harvest schedules reduced the cost to produce carbon credits by up to 17% (at 0% discount rate).
title: Losartan in Combination with the Nanosecond Pulsed Electric Fields Cleared Orthotopic B16F10 Melanoma and Induce in situ Vaccination
Creators: name: Asadipour, Kamal
name: Beebe, Stephen J.
Publisher: name: Old Dominion University Libraries
Year: 2023

description: Melanoma is the most aggressive type of skin cancer with an increasing incidence and mortality worldwide. Its heterogeneity limits its response to existing therapies. In the past few decades, scientists have developed new therapies for melanoma. In many animal models, Nanopulse Stimulation (NPS) eliminates mouse and rat tumors. Additionally, NPS induces protective, vaccine effects such as in situ vaccination and immunity after ablation. However, not all tumor models respond to NPS with in situ vaccination and immunity. Mouse B16f10 melanoma model is one of them. Unlike the rat liver and mouse breast cancer models, immunosuppressive cells in B16f10 tumors were only transiently suppressed from the tumor microenvironment (TME). We hypothesize that this continued TME immunosuppression limits the potential for NSP to induce in situ vaccination and immunity.

Losartan is an angiotensin II receptor blocker commonly prescribed for hypertension. However, Losartan was recently shown to prevent the development of pro-inflammatory monocytes CD14+ CD16+, inhibit the recruitment of monocytes in canine osteosarcoma, and suppress metastasis in preclinical mouse models through blockade of CCL2-CCR2 monocyte recruitment axis. We considered that NPS of B16f10 melanoma in the presence of losartan could induce in situ vaccination by preventing the return of immunosuppressor cells to the TME.

In the absence of losartan, 500 pulses with 200 ns and 50 kV/cm eliminated 3 out of 7 tumors, but none of the 3 tumor-free mice were in situ vaccinated. In contrast, in the presence of losartan, this same condition eliminated 4 out 4 melanoma tumors and 2 of these 4 tumor-free mice were in situ vaccinated; these two mice were males while the 2 tumor-free females did not show in situ vaccination. We hypothesize that the in situ vaccination occurred due to the prevention of immunosuppressive cells from returning to the TME. These findings require further investigation.
Application of Time Transfer Function to McVittie Spacetime: Gravitational Time Delay and Secular Increase in Astronomical Unit
Creators: name: Arakida, Hideyoshi
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We attempt to calculate the gravitational time delay in a time-dependent gravitational field, especially in McVittie spacetime, which can be considered as the spacetime around a gravitating body such as the Sun, embedded in the FLRW (Friedmann-Lemaître-Robertson-Walker) cosmological background metric. To this end, we adopt the time transfer function method proposed by Le Poncin-Lafitte {\it et al.} (Class. Quant. Grav. 21:4463, 2004) and Teyssandier and Le Poncin-Lafitte (Class. Quant. Grav. 25:145020, 2008), which is originally related to Synge's world function $Ω(x_A, x_B)$ and enables to circumvent the integration of the null geodesic equation. We re-examine the global cosmological effect on light propagation in the solar system. The round-trip time of a light ray/signal is given by the functions of not only the spacial coordinates but also the emission time or reception time of light ray/signal, which characterize the time-dependency of solutions. We also apply the obtained results to the secular increase in the astronomical unit, reported by Krasinsky and Brumberg (Celest. Mech. Dyn. Astron. 90:267, 2004), and we show that the leading order terms of the time-dependent component due to cosmological expansion is 9 orders of magnitude smaller than the observed value of $d{\rm AU}/dt$, i.e., $15 \pm 4$ ~[m/century]. Therefore, it is not possible to explain the secular increase in the astronomical unit in terms of cosmological expansion.
description: 13 pages, 2 figures, accepted for publication in General Relativity and Gravitation
The effects of bio-fluid on the internal motion of DNA
Creators: name: Sulaiman, A.
name: Handoko, L. T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The internal motions of DNA immersed in bio-fluid are investigated. The interactions between the fragments of DNA and the surrounding bio-fluid are modeled using the gauge fluid lagrangian. In the model, the bio-fluid is coupled to the standard gauge invariant bosonic lagrangian describing the DNA. It is shown that at non-relativistic limit various equation of motions, from the well-known Sine-Gordon equation to the simultaneous nonlinear equations, can be constructed within a single framework. The effects of bio-fluid are investigated for two cases : single and double stranded DNA. It is argued that the small and large amplitudes of a single stranded DNA motion immersed in bio-fluid can be explained in a natural way within the model as a solitonic wave regardless with the fluid velocity. In contrary the double stranded DNA behaves as regular or damped harmonic oscillator and is highly depending on the fluid velocity.
description: 17 pages, 4 figures
Single-crystal silver nanowires: Preparation and Surface-enhanced Raman Scattering (SERS) property
Creators: name: Sun, Baoliang
name: Jiang, Xiaohong
name: Dai, Shuxi
name: Du, Zuliang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Ordered Ag nanowire arrays with high aspect ratio and high density self-supporting Ag nanowire patterns were successfully prepared using potentiostatic electrodeposition within the confined nanochannels of a commercial porous anodic aluminium oxide (AAO) template. X-ray diffraction and selected area electron diffraction analysis show that the as-synthesized samples have preferred (220) orientation. Transmission electron microscopy and scanning electron microscopy investigation reveal that large-area and ordered Ag nanowire arrays with smooth surface and uniform diameter were synthesized. Surface-enhanced Raman Scattering (SERS) spectra show that the Ag nanowire arrays as substrates have high SERS activity.
description: 5 pages, 4 figures
Additional file 1 of Outcome of ductus arteriosus stenting including vertical tubular and convoluted tortuous ducts with emphasis on technical considerations
Creators: name: Bahaidarah, Saud
name: Al-Ata, Jameel
name: Alkhushi, Naif
name: Azhar, Ahmad
name: Zaher, Zaher
name: Alnahdi, Bayan
name: Abdelsalam, Mohamed
name: Elakaby, Ahmed
name: Dohain, Ahmed
name: Abdelmohsen, Gaser
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. Appendix to manuscript.
What it All Comes Down To: Women's Liberation and Oppression Continues Breathing Life into Alanis Morissette's Jagged Little Pill
Creators: name: Schomburg, Michelle L
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Communication studies
Media studies

description: Alanis Morissette’s 1995 album Jagged Little Pill was released during the third wave of feminism, when sexual liberation for women was considered a priority and was especially prevalent in music with the rise of riot grrrl groups. Morissette’s album has transcended into the current fourth wave of feminism because she wrote palatable songs about female oppression and sexual liberation, which are tenets that were shared between the third and fourth waves of feminism. With the development of social media, feminism became decentralized and made it easier for Jagged Little Pill to grow in popularity and continue to resonate with a new generation of feminists almost thirty years after its release. Through analyzing the album using ideological criticism, this thesis will uncover different themes of oppression and liberation experienced by women throughout these two waves of feminism.
Investigating students’ performance at self-regulated learning and its effects on learning outcomes in chemistry class at the senior secondary school
Creators: name: Wu, Min
name: Sun, Daner
name: Yang, Yuqin
name: Li, Mengxue
name: Sun, Jin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: The impact of self-regulated learning (SRL) on students’ performance in various subjects has been extensively studied. However, there has been limited research on how task-specific SRL skills and self-reported SRL skills affect students’ learning outcomes in chemistry classes at senior secondary schools. To address this gap, we examined the task-specific SRL skills, self-reported SRL skills, and learning outcomes of a group of Grade 10 students (n = 170) studying the topic: Changes of Charged Electrolyte Solutions. Data was collected through a self-report SRL skills survey, a task-specific SRL skills survey, and an achievement test, and a path analysis was conducted to explore the relationship and effects between SRL skills and learning outcomes. Our findings revealed a direct relationship between students’ task-specific SRL skills and their chemistry achievement. The clustering analysis showed that a significant number of students had SRL skills at the middle level in chemistry learning. Additionally, students with different SRL levels performed differently at specific SRL phases and strategies. These findings have important implications for teaching strategies aimed at promoting students’ SRL and for the assessment of SRL in science education.
Propuesta de abordaje transversal del concepto diferencial de curvatura en situaciones físicas
Creators: name: López-Reyes, Mauricio
Publisher: name: arXiv
Year: 2024
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: During the process of teaching the concept of derivative, it is common and natural to refer to geometric interpretations, such as the use of the tangent line and the maximum and minimum points of a function, to illustrate the scope of the derivative. In this work, an inclusive and applied way of the concept of curvature differential is presented, specifically with the intervention of problems of Newton's mechanics, whose purpose is double, on the one hand, to provide the derivative with a highly versatile sense to model systems, and on the other hand; to approach diverse classic topics of the initial physics courses from a didactic proposal centered on the concept of curvature.
description: in Spanish language
Analysis of the role of talin as a mechanosensor at the cell adhesions to the extracellular matrix in Drosophila melanogaster
Creators: name: Hakonardottir, Gudlaug Katrin
Publisher: name: University of British Columbia
Year: 2015

description: Cells in multicellular organisms are arranged in complex three-dimensional patterns. To achieve such complexity, cells must form adhesive contacts with the extracellular matrix (ECM). The most common adhesion receptors that mediate cell-ECM adhesions are the integrins. A large cytoplasmic network of proteins, namely the integrin adhesion complex (IAC) is recruited to the site of adhesions. Regulated assembly and disassembly, or turnover, of the IAC is essential for dynamic cell movements and tissue maintenance. In this project, I sought to investigate the role of mechanical force on the turnover of talin, a core component of the IAC and an essential linker between integrins and the actin cytoskeleton. To investigate the turnover of talin in vivo, I performed fluorescence recovery after photobleaching (FRAP) on the myotendionous junctions (MTJs) in live Drosophila embryos and larvae. I used temperature sensitive mutants to alter the force acting on the MTJs. To better understand talin turnover, I collaborated with people from Dan Coombs’ lab (Department of Mathematics, UBC) to develop a mathematical model for the turnover of cytoplasmic adhesion proteins. This model is parametrized by four rate constants: talin binding on and off the adhesion complex at the plasma membrane, talin delivery to the plasma membrane due to the assembly of the IAC and talin removal from the plasma membrane due to the disassembly of the IAC. I hypothesized that changes in force would affect talin turnover and certain functional domains in talin would be required for mechanosening at the MTJs. I used targeted point mutations in the functional domains of talin to investigate their role in mechanosensing. Consistent with my hypothesis, I found out that disrupting functional domains in talin either abrogates or severely affect the ability of talin to respond to changes in force. First, these results provide direct evidence on how force is sensed at the adhesion complex. Secondly, this is the first in vivo study where four rate constants are used to characterize the turnover of a cytoplasmic protein.
Cosymmetries and Nijenhuis recursion operators for difference equations
Creators: name: Mikhailov, Alexander V.
name: Wang, Jing Ping
name: Xenitidis, Pavlos
Publisher: name: arXiv
Year: 2010
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: In this paper we discuss the concept of cosymmetries and co--recursion operators for difference equations and present a co--recursion operator for the Viallet equation. We also discover a new type of factorisation for the recursion operators of difference equations. This factorisation enables us to give an elegant proof that the recursion operator given in arXiv:1004.5346 is indeed a recursion operator for the Viallet equation. Moreover, we show that this operator is Nijenhuis and thus generates infinitely many commuting local symmetries. This recursion operator and its factorisation into Hamiltonian and symplectic operators can be applied to Yamilov's discretisation of the Krichever-Novikov equation.
Scale invariant extension of the standard model with strongly interacting hidden sector
Creators: name: Hur, Taeil
name: Ko, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present a scale invariant extension of the standard model with new QCD-like strong interaction in the hidden sector. A scale $Λ_H$ is dynamically generated in the hidden sector by dimensional transmutation, and chiral symmetry breaking occurs in the hidden sector. This scale is transmitted to the SM sector by a real singlet scalar messenger S, and can trigger electroweak symmetry breaking (EWSB). Thus all the mass scales in this model arises from the hidden sector scale $Λ_H$ which has quantum mechanical origin. Furthermore the lightest hadrons in the hidden sector is stable by the flavor conservation of the hidden sector strong interaction, could be the cold dark matter (CDM). We study collider phenomenology, and relic density and direct detection rates of the CDM of this model.
description: Accepted for publication in Phys. Rev. Lett
Additional file 1 of Entrustment in physician-patient communication: a modified Delphi study using the EPA approach
Creators: name: Younas, Ayesha
name: Khan, Rehan Ahmed
name: Yasmin, Raheela
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Percentage agreement and p-values for final competencies included in each EPA at the end of Round III. 1. The data set shows mean percentage agreement of experts on competencies included in each EPA at the end of round III of the Delphi process. 2. p-values for each competency, calculated by applying the McNemar test to check for response stability in two successive rounds.
Effect of FIR Fluxes on Constraining Properties of YSOs
Creators: name: Ha, Ji-Sung
name: Lee, Jeong-Eun
name: Jeong, Woong-Seob
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Young Stellar Objects (YSOs) in the early evolutionary stages are very embedded, and thus they emit most of their energy at long wavelengths such as far-infrared (FIR) and submillimeter (Submm). Therefore, the FIR observational data are very important to classify the accurate evolutionary stages of these embedded YSOs, and to better constrain their physical parameters in the dust continuum modeling. We selected 28 YSOs, which were detected in the AKARI Far-Infrared Surveyor (FIS), from the Spitzer c2d legacy YSO catalogs to test the effect of FIR fluxes on the classification of their evolutionary stages and on the constraining of envelope properties, internal luminosity, and UV strength of the Interstellar Radiation Field (ISRF). According to our test, one can mis-classify the evolutionary stages of YSOs, especially the very embedded ones if the FIR fluxes are not included. In addition, the total amount of heating of YSOs can be underestimated without the FIR observational data.
title: HSP90 Inhibitors Protective Effects on Endothelial Barrier Function Are Directly Related to HSP70 Levels
Creators: name: Colunga Biancatelli, Ruben Manuel Luciano
name: Osei-nkansah, Michael
name: Solopov, Pavel
name: Day, Tierney
name: Gregory, Betsy W.
name: Dimitropoulou, Christiana
name: Catravas, John D.
Publisher: name: Old Dominion University Libraries
Year: 2023

description: Background: Hydrochloric acid (HCl) is a common chemical used in various industries, medical practices, and scientific laboratories. HCl exposure can lead to respiratory failure, acute respiratory distress syndrome (ARDS), and, depending on the duration of exposure, death. Some of the dangerous effects of HCl are related to its ability to disrupt the alveolar-capillary barrier function, resulting in fluid leakage into the alveoli and acutely provoking the development of ARDS. Heat Shock Proteins (HSPs) are molecular chaperones that assist in the folding, stabilization, and activity of proteins involved in many cellular processes such as cell cycle control, cell survival, and cell signaling. The use of HSP90 inhibitors disrupts the stability of its “client proteins” resulting in anti-inflammatory and antifibrotic effects. It is not clear if these effects are related to HSP90 co-chaperone HSP70. We hypothesized that inhibition of HSP90, together with overexpression of HSP70, would have a stronger beneficial effect on endothelial barrier function disrupted by HCl.

Methods: Cultured Human lung endothelial cells (HLMVECs) were treated with different concentrations of HSP 90 inhibitor TAS-116 and HSP 70 inducer Geranylgeranyl acetone (GGA). Cells were exposed to HCl and Electric cell-substrate impedance sensing measured changes in resistance.

Results: Cells treated with TAS-116 and GGA had a statistically significant difference in membrane resistance compared to the control group of saline-treated cells. This suggests the effectiveness of TAS-116 and GGA in maintaining endothelial barrier function after exposure to an inflammatory agent like HCl. However, we found no statistically significant difference between cells treated with TAS-116, TAS-116+GGA, and control cells, suggesting that these treatments may have the potential to bring endothelial barrier function back to baseline.

Conclusions: Our findings show that the use of HSP90 inhibitors and HSP70 inducers may represent a valid combined therapy to help mitigate the effects of HCl-induced inflammation in HLMVECs.
Associated Press-NORC Center for Public Affairs Research Poll: The March 2018 AP-NORC Center Poll
Creators: name: Associated Press
name: NORC At The University Of Chicago
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Direction of country (2); President Donald Trump job performance (1); national economy (1); personal finances (1); respect for U.S. around the world (1); U.S. national security (1); U.S. influence around the world (1); Trump's handling of various issues (7); amount respondent has heard or read about new tax law passed by Congress in December (1); impact of new tax law (8); important factors in U.S. trade agreement negotiations with other countries (7); favor/oppose tariff (import tax) on steel and aluminum (1); impact of tariff on steel and aluminum (2); concern about North Korea's nuclear weapons program (4); negotiations between U.S. and North Korea (2); gun laws in U.S. (2); favor/oppose various gun policies (7); owning gun protects/puts safety at risk (1); impact of stricter gun laws (4); guns in respondent's home (1); gun ownership (1).
Modeling comminution processes in ball mills as a canonical ensemble
Creators: name: Sunnardianto, G. K.
name: Muhandis
name: Diana, F. N.
name: Handoko, L. T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Computational Physics (physics.comp-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A new approach to describe comminution processes in general ball mills as a macroscopic canonical ensemble is proposed. Using hamiltonian method, the model is able to take simultaneously into account the internal dynamics from mechanical motions inside the vial and external effects like electromagnetic and gravitational forces. Relevant physical observables are extracted using statistical mechanics approach through partition function at finite temperature. The method enables numerical calculation using Monte Carlo technique to obtain, for instance particle number evolution in term of system temperature. It is argued that the method is experimentally more verifiable than the conventional approaches based on geometrical displacements. An example of simulation for typical spex mill is also given.
description: 16 pages, 7 figures
Optimization of Fast-Decodable Full-Rate STBC with Non-Vanishing Determinants
Creators: name: Ren, Tian Peng
name: Guan, Yong Liang
name: Yuen, Chau
name: Zhou, Yue
name: Zhang, Er Yang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Full-rate STBC (space-time block codes) with non-vanishing determinants achieve the optimal diversity-multiplexing tradeoff but incur high decoding complexity. To permit fast decoding, Sezginer, Sari and Biglieri proposed an STBC structure with special QR decomposition characteristics. In this paper, we adopt a simplified form of this fast-decodable code structure and present a new way to optimize the code analytically. We show that the signal constellation topology (such as QAM, APSK, or PSK) has a critical impact on the existence of non-vanishing determinants of the full-rate STBC. In particular, we show for the first time that, in order for APSK-STBC to achieve non-vanishing determinant, an APSK constellation topology with constellation points lying on square grid and ring radius $\sqrt{m^2+n^2} (m,n\emph{\emph{integers}})$ needs to be used. For signal constellations with vanishing determinants, we present a methodology to analytically optimize the full-rate STBC at specific constellation dimension.
description: Accepted by IEEE Transactions on Communications
Local Policies for Environmental Justice: A National Scan
Creators: name: Geertsma, Meleah
Publisher: name: No Publisher Supplied
Year: 2019

description: The following report provides a comprehensive look at recent efforts in 23 cities, three counties and two utilities across the United States to address environmental injustices through innovative reforms of zoning, land use, and other local policies. While local zoning codes and land use policies historically have been tools for segregating people and concentrating pollution in low-income communities and communities of color, community-based advocacy can transform these same tools into means for addressing cumulative burdens borne by environmental justice communities.
Effect of Langmuir monolayer of bovine serum albumin protein on the morphology of calcium carbonate
Creators: name: Xue, Zhong-Hui
name: Dai, Shu-Xi
name: Hu, Bin-Bin
name: Du, Zu-Liang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Bovine serum albumin (BSA) Langmuir monolayer, as a model of biomineralization-associated proteins, was used to study its effect on regulated biomineralization of calcium carbonate. The effects of the BSA Langmuir monolayer and the concentration of the subphase solution on the nucleation and growth processes and morphology of the calcium carbonate crystal were investigated. The morphology and polymorphic phase of the resulting calcium carbonate crystals were characterized by scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD). Moreover, the interaction mechanisms of the subphase solution with the BSA Langmuir monolayer were discussed. It was found that BSA Langmuir monolayer could be used as a template to successfully manipulate the polymorphic phase and crystal morphology of calcium carbonate and had obvious influence on the oriented crystallization and growth. The final morphology or aggregation mode of the calcite crystal was closely dependent on the concentration of calcium bicarbonate solution. It is expected that this research would help to better understand the mechanism of biomineralization by revealing the interactions between protein matrices and crystallization of calcium carbonate crystal.
description: 4 pages, 4 figures
H5BW12O40 as a green and efficient homogeneous but recyclable catalyst in the synthesis of 4H-Pyrans via multicomponent reaction
Creators: name: Mommahed Heravi, Majid
name: Mirzaei, Masoud
name: Yahya Shirazi Beheshtiha, Seyed
name: Zadsirjan, Vahideh
name: Ameli, Fatemeh Mashayekh
name: Bazargan, Maryam
Publisher: name: figshare
Year: 2022
Subjects: subject: 30102 Electroanalytical Chemistry
subject: FOS: Chemical sciences
subject: 30701 Quantum Chemistry
subject: 39904 Organometallic Chemistry
subject: Organic Chemistry
subject: 30502 Natural Products Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: Nuclear Chemistry
subject: 30504 Organic Green Chemistry
subject: 30303 Optical Properties of Materials
subject: 30302 Nanochemistry and Supramolecular Chemistry

description: Keggin-type heteropolyacid, H5BW12O40 (BWA) with a higher negative charge and stronger Brønsted acidity comparing to Si and P derivatives was used as an efficient, green, and reusable catalyst in a three-component reaction involving the cyclocondensation of various β-dicarbonyl compounds, differently substituted aromatic aldehydes and malononitrile in EtOH/H2O for the facile, clean, and high yielding synthesis of 4H-pyrans. All reactions were completed in short times and the products were obtained in good to excellent yields. The reaction medium could be recycled and reused several times without any loss of efficiency.
Additional file 1 of Investigating the factor structure of a translated recovery-orientation instrument in inpatient treatment for substance use disorder
Creators: name: Johannessen, Dagny Adriaenssen
name: Geirdal, Amy Østertun
name: Nordfjærn, Trond
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Recovery Self-Assessment – Norwegian (RSA-N).
A group model for stable multi-subject ICA on fMRI datasets
Creators: name: Varoquaux, G.
name: Sadaghiani, S.
name: Pinel, P.
name: Kleinschmidt, A.
name: Poline, J. B.
name: Thirion, B.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Spatial Independent Component Analysis (ICA) is an increasingly used data-driven method to analyze functional Magnetic Resonance Imaging (fMRI) data. To date, it has been used to extract sets of mutually correlated brain regions without prior information on the time course of these regions. Some of these sets of regions, interpreted as functional networks, have recently been used to provide markers of brain diseases and open the road to paradigm-free population comparisons. Such group studies raise the question of modeling subject variability within ICA: how can the patterns representative of a group be modeled and estimated via ICA for reliable inter-group comparisons? In this paper, we propose a hierarchical model for patterns in multi-subject fMRI datasets, akin to mixed-effect group models used in linear-model-based analysis. We introduce an estimation procedure, CanICA (Canonical ICA), based on i) probabilistic dimension reduction of the individual data, ii) canonical correlation analysis to identify a data subspace common to the group iii) ICA-based pattern extraction. In addition, we introduce a procedure based on cross-validation to quantify the stability of ICA patterns at the level of the group. We compare our method with state-of-the-art multi-subject fMRI ICA methods and show that the features extracted using our procedure are more reproducible at the group level on two datasets of 12 healthy controls: a resting-state and a functional localizer study.
Imagined communities, symbolic capital, and the mobilization of individual linguistic resources
Creators: name: Mendoza, Anna Veronica
Publisher: name: University of British Columbia
Year: 2015

description: Critical research in TESL (Teaching English as a Second Language) involves a delicate balance between two paradigms. On the one hand, the researcher strives to unearth and explain processes of systemic inequality and perpetual marginalization, as English language learners worldwide strive to accumulate linguistic and cultural capital. On the other hand, the researcher must recognize that learners have the right to invest in English, imagine future identities, and conceptualize their journeys as language learners as connected to a “better life story” (Barkhuizen, 2010; Darvin & Norton, 2015). This study employs narrative inquiry in an attempt to reconcile the two paradigms and give a holistic account of students’ experiences. The narratives of eight international graduate students in Canada reveal that those who attended international schools and were immersed in Western popular and academic culture prior to their arrival were advantaged in academic, professional, and social contexts. Additionally, while all eight established social networks in Canada, only the one white student from Western Europe who majored in North American civilization had a social network comprised mainly of Canadians. Nevertheless, four students reported being well adjusted in Canada, personally and professionally – as each had used a set of strategies tailored to her/his individual situation to pursue an imagined future. Findings suggest that each international student must draw on her/his specific linguistic repertoire and intellectual resources to effectively navigate real and imagined communities.
Black-Hole Mass and Growth Rate at z~4.8: A Short Episode of Fast Growth Followed by Short Duty Cycle Activity
Creators: name: Trakhtenbrot, Benny
name: Netzer, Hagai
name: Lira, Paulina
name: Shemmer, Ohad
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present new Gemini-North/NIRI and VLT/SINFONI H-band spectroscopy for a flux limited sample of 40 z~4.8 active galactic nuclei, selected from the Sloan Digital Sky Survey. The sample probably contains the most massive active black holes (BHs) at this redshift and spans a broad range in bolometric luminosity, 2.7x10^46< L_bol < 2.4x10^47 erg/sec. The high-quality observations and the accurate fitting of the MgII(2800A) line, enable us to study, systematically, the distribution of BH mass (M_BH) and normalized accretion rate (L/L_Edd) at z~4.8. We find that 10^8 < M_BH < 6.6x10^9 M_sun, with a median of ~8.4x10^8 M_sun. We also find that 0.2 < L/L_Edd < 3.9 with a median of ~0.6. Most of these sources had enough time to grow to their observed mass at z~4.8 from z=20, assuming a range of seed BH masses, with ~40% that are small enough to be stellar remnants. Compared to previously studied samples at z~2.4 and 3.3, the masses of the z~4.8 BHs are typically lower by ~0.5 dex. and their L/L_Edd is higher by a similar factor. The new z~4.8 sample can be considered as the progenitor population of the most massive BHs at z~2.4 and 3.3. Such an evolutionary interpretation requires that the growth of the BHs from z~4.8 to z~3.3 and z~2.4 proceeds with short duty cycles, of about 10-20%, depending on the particular growth scenario.
description: 14 pages and 8 figures. Accepted for publication in ApJ
Additional file 1 of Abnormal anther development leads to lower spikelet fertility in rice (Oryza sativa L.) under high temperature during the panicle initiation stage
Creators: name: Hu, Qiuqian
name: Wang, Wencheng
name: Lu, Qifan
name: Huang, Jianliang
name: Peng, Shaobing
name: Cui, Kehui
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer

description: Additional file 1.
title: HSP70 Is a Critical Regulator of HSP90 Inhibitor Effectiveness in Preventing HCl-induced Chronic Lung Injury and Pulmonary Fibrosis in Mice
Creators: name: Colunga Biancatelli, Ruben Manuel Luciano
name: Solopov, Pavel
name: Day, Tierney
name: Dimitropoulou, Christiana
name: Catravas, John D.
Publisher: name: Old Dominion University Libraries
Year: 2023

description: Rationale: Exposure to Hydrochloric acid (HCl) can provoke acute and chronic lung injury; because of its extensive use in the industry, accidental exposures occur and represent a threat to public health. Heat shock protein 90 (HSP90) is a chaperone involved in inflammation and fibrosis; its activity is inversely related to the levels of its co-chaperone HSP70. We hypothesized that administration of geranylgeranyl-acetone (GGA), an HSP70 inducer, or gefitinib (GFT), an HSP70 suppressant, alone or in combination with the HSP90 inhibitor, TAS-116, would improve or worsen, respectively, HCl-induced chronic lung injury and pulmonary fibrosis in mice.

Methods: C57BL/6J mice were intratracheally instilled with 2µl/g 0.1N HCl, and, after 24h, treated with 1) vehicle; 2) GGA, 200 mg/kg 3x/week per os; 3) GFT, 200 mg/kg 3x/week per os; 4) TAS-116, 7 mg/kg 5x/week per os; 5) TAS-116 + GGA; 6) TAS-116 + GFT. Molecular, functional, and histological outcomes were investigated 30 days after HCl.

Results: GGA reduced HCl-induced alveolar inflammation, activation (phosphorylation) of ERK and HSP90, the deposition of Fibronectin, Elastin, Collagen and TGF-β, the histological evidence of fibrosis (Ashcroft score and NLRP3 staining), and lung dysfunction (i.e. Pressure-Volume loops, Elastance (Ers) and Resistance (Rrs)). GFT, alone, did not affect HCl-induced toxicity. TAS-116 alone blocked HCl-induced chronic lung injury and, when co-administered with GGA, resulted in an increased HSP70 levels and slightly improvement in molecular signaling and lung function. Conversely, GFT impaired the antidotal effects of TAS-116 resulting in persistent inflammation, activation of HSP90 and pulmonary fibrosis.

Conclusions: TAS-116 represents a valid drug candidate for HCl-induced respiratory toxicity. HSP70 induction by GGA may represent a novel therapeutic strategy to potentiate the anti-fibrotic effects of HSP90 inhibitors.

Supported by the CounterACT Program, National Institutes of Health Office of the Director (NIH OD) and the National Institute of Environmental Health Sciences (NIEHS) grant number U01ES030674.
Additional file 1 of Failure of Israeli pediatric residency curricula to cover child development and special education issues: results of a national survey on levels of knowledge
Creators: name: Tokatly Latzer, Itay
name: Grossman, Zachi
name: Sachs, Nimrod
name: Yahal, Orr
name: Even-Zohar, Daniel
name: Carmon, Lior
name: Flor-Hirsch, Hadar
name: Ringel, Amit
name: Farah, Christopher Fady
name: Avni-Maskit, Moran
name: Leitner, Yael
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology

description: Additional file 1
Bounds on the Complexity of Halfspace Intersections when the Bounded Faces have Small Dimension
Creators: name: Eppstein, David
name: Löffler, Maarten
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computational Geometry (cs.CG)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences
subject: F.2.2

description: We study the combinatorial complexity of D-dimensional polyhedra defined as the intersection of n halfspaces, with the property that the highest dimension of any bounded face is much smaller than D. We show that, if d is the maximum dimension of a bounded face, then the number of vertices of the polyhedron is O(n^d) and the total number of bounded faces of the polyhedron is O(n^d^2). For inputs in general position the number of bounded faces is O(n^d). For any fixed d, we show how to compute the set of all vertices, how to determine the maximum dimension of a bounded face of the polyhedron, and how to compute the set of bounded faces in polynomial time, by solving a polynomial number of linear programs.