cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sound change in Kulin
Creators: name: Blake, Barry J
name: Reid, Julie
Publisher: name: La Trobe
Year: 2023

description: When the British took over what is now Victoria in the nineteenth century, a group of closely related tongues was spoken over most of the western and central part of the state. Schmidt called these tongues Kuliyn from the word kuliyn ‘man’ which occurred in central Victoria (Schmidt 1919). We will retain Schmidt’s term kulin and we use the term ‘tongue’ where we want to avoid the distinction between language and dialect.
Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions
Creators: name: Klimczak, Leszek J.
name: Gordenin, Dmitry A.
name: Malc, Ewa
name: Mav, Deepak
name: Shah, Ruchir
name: Sterling, Joan
name: Mieczkowski, Piotr A.
name: Harris, Shawn
name: Roberts, Steven A.
name: Resnick, Michael A.
name: Thompson, Cole
name: Kryukov, Gregory V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Mutations are typically perceived as random, independent events. We describe here non-random clustered mutations in yeast and in human cancers. Genome sequencing of yeast grown under chronic alkylation damage identified mutation clusters that extend up to 200 kb. A predominance of “strand-coordinated” changes of either cytosines or guanines in the same strand, mutation patterns and genetic controls indicated that simultaneous mutations were generated by base alkylation in abnormally long single-strand (ss)DNA formed at double-strand breaks (DSBs) and replication forks. Significantly, we found mutation clusters with analogous features in sequenced human cancers. Strand-coordinated clusters of mutated cytosines or guanines often resided near chromosome rearrangement breakpoints and were highly enriched with a motif targeted by APOBEC family cytosine-deaminases, which strongly prefer ssDNA. These data indicate that hyper-mutation via multiple simultaneous changes in randomly formed ssDNA is a general phenomenon that may be an important mechanism producing rapid genetic variation.
Nursing Robot Datasets
Creators: name: Laakasuo, Michael
Publisher: name: figshare
Year: 2022
Subjects: Personality, Social and Criminal Psychology

description: All quantitative datasets for the following publication. https://psyarxiv.com/bkhyq/
 https://onlinelibrary.wiley.com/doi/10.1002/ejsp.2890
 Only the variables included in the publication are published. There is still data for future publications.
Brief an Giuseppe Verzaglia
Creators: name: Iselin, Jakob Christoph
Publisher: name: [s.n.]
Year: 1711
Subjects: Bernoulli, Johann1667-1748JohannBernoulli
Burnet, William1688-1729
L'Hôpital, Guillaume François Antoine de1661-1704Guillaume François AntoineL'Hospital
Reboulet, Paul1655-1710

description: Iselin antwortet gemäss Anleitung von Joh. B. auf Verzaglias Rechtfertigungsversuche zu den Vorwürfen Joh. B.s. Dieser hatte Verzaglia auch gegenüber Iselin weiterer Unhöflichkeiten und eines generell schlechten Benehmens bezichtigt. P.S. Das an das Haus "Zum Storchen" adressierte Billet haben die Verwandten Reboulets richtig besorgt.
description: von Johann Christoph Iselin
description: Der Brief Iselins ist offenbar im Auftrag von Joh. I B. als Antwort auf den Brief Verzaglias vom 25.3.1710 geschrieben. Iselins Entwurf enthält Marginalien von der Hand Joh. I B.s mit Angaben, wo diese in Iselins Brieftext einzufügen sind. Iselins Brief wurde daher dem Briefwechsel von Johann I Bernoulli zugeordnet.
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Datenimport aus LIDOS / Bernoulli (2004-07-02)
description: Digitalisierung=Digitization=Numérisation Oktober 2022 TIFF
Javalbia Smit & Pešić, 2014, s. str.
Creators: name: Smit, Harry
name: Pešić, Vladimir
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Aturidae
Javalbia

description: Subgenus Javalbia s. str.
Diagnosis (after Cook 1974, revised). Glandularia platelets in dorsal furrow greatly enlarged. Dorsal shield either indented anteriorly and with glandularia lying free in these indentations, or without indentations and these glandularia fused with dorsal shield. Excretory pore lying on a small platelet posterior to genital field in male. In the female the excretory pore is either fused or separated from the postgenital sclerite. Vgl-4 either free or fused with ventral shield.
The nominate subgenus occurs in the Palaearctic and Oriental regions.
Key to the Javalbia species from Borneo
1. IV-leg very heavy, with one large and one smaller claw.......................................... J. uncinata n. sp.
- IV-leg not much heavier than I-III-leg, both claws not enlarged, symmetrical...................................... 2
2. Dorsal shield with only two pairs of glandularia, lateral margins reticulated......................... J. reticulata n. sp.
- Dorsal shield with three or more pairs of glandularia, lateral margins not reticulated................................ 3
3. Glandularia platelets in dorsal furrow very elongated, cxgl-4 on a separate platelet................... J. montana n. sp.
- Glandularia platelets in dorsal furrow small or boat-shaped, cxgl-4 either fused to ventral shield or separated, but not lying on a separate platelet..................................................................................... 4
4. Dgl-1 close to lateral margin of dorsal shield, excretory pore on a separate platelet.................... J. solitaria n. sp. Dgl-1 away from lateral margin of dorsal shield, excretory pore fused with dorsal shield or lying free.................. 5
5. Dgl-2 with enlarged hyaline setae........................................................... J. magniseta n. sp.
- Setae of dgl-2 normal in shape........................................................................... 6
6. Postocularia slightly posterior to dgl-1, glandularia platelets in dorsal furrow boat-shaped............ J. borneoensis n. sp.
- Postocularia distinctly anterior to dgl-1, glandularia platelets in dorsal furrow rounded to slightly elliptical.................................................................................................. J. kinabaluensis n. sp.
description: Published as part of Smit, Harry & Pešić, Vladimir, 2014, Water mites from Mount Kinabalu and the Crocker Range, Borneo, Malaysia (Acari: Hydrachnidia), with the description of 34 new species, pp. 1-71 in Zootaxa 3876 (1) on pages 38-49, DOI: 10.11646/zootaxa.3876.1.1, http://zenodo.org/record/287281
Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis
Creators: name: Swahari, Vijay
name: Gama, Vivian
name: Deshmukh, Mohanish
name: Bower, Jacquelyn J.
name: Pevny, Larysa H.
name: Fagan, B. Matthew
name: Dumitru, Raluca
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Human embryonic stem (hES) cells activate a rapid apoptotic response after DNA damage but the underlying mechanisms are unknown. A critical mediator of apoptosis is Bax, which is reported to become active and translocate to the mitochondria only after apoptotic stimuli. Here we show that undifferentiated hES cells constitutively maintain Bax in its active conformation. Surprisingly, active Bax was maintained at the Golgi rather than at the mitochondria, thus allowing hES cells to effectively minimize the risks associated with having pre-activated Bax. After DNA damage, active Bax rapidly translocated to the mitochondria by a p53-dependent mechanism. Interestingly, upon differentiation, Bax was no longer active and cells were not acutely sensitive to DNA damage. Thus, maintenance of Bax in its active form is a unique mechanism that can prime hES cells for rapid death, likely to prevent the propagation of mutations during the early critical stages of embryonic development.
Comparison of different Tidal Disruption Event light curve models with TiDE, a new modular open source code
Creators: name: Kovács-Stermeczky, Zsófia V.
name: Vinkó, József
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A tidal disruption event (TDE) occurs when a supermassive black hole disrupts a nearby passing star by tidal forces. The subsequent fallback accretion of the stellar debris results in a luminous transient outburst. Modeling the light curve of such an event may reveal important information, for example the mass of the central black hole. This paper presents the TiDE software based on semi-analytic modeling of TDEs. This object-oriented code contains different models for the accretion rate and the fallback timescale $t_{\rm min}$. We compare the resulting accretion rates to each other and with hydrodynamically simulated ones and find convincing agreement for full disruptions. We present a set of parameters estimated with TiDE for the well-observed TDE candidate AT2019qiz, and compare our results with those given by the MOSFiT code. Most of the parameters are in reasonable agreement, except for the mass and the radiative efficiency of the black hole, both of which depend heavily on the adopted fallback accretion rate.
description: 17 pages, 12 figures, 2 tables, accepted in PASP
Anleitungsbuch "Principes de Fabrique / Analyse des Etoffes"
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1870

description: Undatiert
description: Trägermaterial: Papier, Textilie
description: Französisch
description: Verzeichnung=Description=Inventaire 05.10.2022 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
A Two-parameter Extension of Classical Nucleation Theory
Creators: name: Lutsko, James F.
name: Durán-Olivencia, Miguel A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A two-variable stochastic model for diffusion-limited nucleation is developed using a formalism derived from fluctuating hydrodynamics. The model is a direct generalization of the standard Classical Nucleation Theory. The nucleation rate and pathway are calculated in the weak-noise approximation and are shown to be in good agreement with direct numerical simulations for the weak-solution/strong-solution transition in globular proteins. We find that Classical Nucleation Theory underestimates the time needed for the formation of a critical cluster by two orders of magnitude and that this discrepancy is due to the more complex dynamics of the two variable model and not, as often is assumed, a result of errors in the estimation of the free energy barrier.
description: 25 pages, 12 figures
Theoriebuch Dekomposition, I. Kurs der Zürcherischen Seidenwebschule
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1907

description: von Eduard Weinmann
description: Trägermaterial: Papier, Textilie
description: Deutsch
description: Verzeichnung=Description=Inventaire 05.10.2022 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis
Creators: name: Zhang, Liyong
name: DeSimone, Michelle C.
name: Gamper, Armin M.
name: Qiao, Xinxian
name: Rathmell, W. Kimryn
name: Kim, Jennifer
name: Wan, Yong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The transcription factor Krüppel-like factor 4 (KLF4) is an important regulator of cell fate decision, including cell cycle regulation, apoptosis, and stem cell renewal, and plays an ambivalent role in tumorigenesis as a tissue specific tumor suppressor or oncogene. Here we report that the Von Hippel-Lindau gene product, pVHL, physically interacts with KLF4 and regulates its rapid turnover observed in both differentiated and stem cells. We provide mechanistic insights into KLF4 degradation and show that pVHL depletion in colorectal cancer cells leads to cell cycle arrest concomitant with increased transcription of the KLF4-dependent p21 gene. Finally, immunohistochemical staining revealed elevated pVHL and reduced KLF4 levels in colon cancer tissues. We therefore propose that unexpectedly pVHL, via the degradation of KLF4, is a facilitating factor in colorectal tumorigenesis.
PTB-Anforderungen 5.02 „Lagerbehälter“. Ausgabe Juli 2020
Creators: name: Physikalisch-Technische Bundesanstalt (PTB)
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2020
Subjects: PTB-Anforderungen
Volumen
Messgeräte zur Bestimmung des Volumens
Lagerbehälter
PTB-A 5.02

description: PTB-Anforderungen enthalten Anforderungen zu technischen Spezifikationen und Verwendungspflichten für Messgeräte, die den Regelungen des Mess- und Eichrechts unterliegen. Sie werden von der PTB unter Beteiligung der betroffenen Kreise erstellt. PTB-Anforderungen bestehen aus zwei Teilen. Der erste Teil behandelt Regeln und technische Spezifikationen für Messgeräte, um die wesentlichen Anforderungen an Messgeräte nach § 6 des Mess- und Eichgesetzes i. V. m. § 7 der Mess- und Eichverordnung zu konkretisieren. Der zweite Teil behandelt Regeln und Erkenntnisse zur näheren Bestimmung der Pflichten von Personen, die Messgeräte oder Messwerte verwenden, nach §§ 31 und 33 Mess- und Eichgesetz und §§ 22 und 23 Mess- und Eichverordnung. Diese PTB-Anforderungen umfassen die Teile 1 und 2 für folgende Messgeräte nach § 1 Absatz 1 Nummer 5 der Mess- und Eichverordnung zur Bestimmung des Volumens: Lagerbehälter. Diese PTB-Anforderungen befassen sich nicht mit separaten automatischen Füllstandsmessgeräten oder Peilbandmaßen. Diese PTB-Anforderungen ersetzen die bisherigen PTB-A 4.2 der Ausgabe Dezember 2010, soweit diese Lagerbehälter betreffen.
65 Briefe, 27 Umschläge, 4 Beilagen an Johann George Zimmermann
Brief an Zimmermann ...
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1772

description: von Johann Caspar Lavater
description: Davon 1 Brief ohne Jahr (FA Lav Ms 589d.4, Nr. 15)
description: FA Lav Ms 589d.2, Nr. 7a hierher versetzt aus FA Lav Ms 589e.2
description: Davon 1 Brief mit Beischrift von Johann Konrad Pfenninger (FA Lav Ms 589d.4, Nr. 1a); 2 Briefe mit Beischrift von Barbara Schulthess (FA Lav Ms 589d.4, Nr. 16 und FA Lav Ms 589d.5, Nr. 14); 1 Brief mit Beischrift von Anna Lavater (FA Lav Ms 589d.5, Nr. 8)
description: Mit eigenhändiger Notiz Zimmermanns über den Erhalt der Karte auf der Rückseite von FA Lav Ms 589d.2, Nr. 8; Pro Memoria Lavaters mit eigenhändiger Anwort Zimmermanns auf der Rückseite, dat. Dezember 1775, und weiterer Anwort Lavaters (FA Lav Ms 589d.5, Nr. 14a)
description: Davon 2 Briefe betitelt und aufgebaut als "Register allerley Sachen..." bzw. "allerley unmerkwürdiger Sachen...": FA Lav Ms 589d.4, Nr. 17, dat. 30.5.-3.6.1775 und FA Lav Ms 589d.5, Nr. 13a, dat. 14.-17.11.1775
description: Dabei 2 Briefe von Barbara Schulthess an Lavater (FA Lav Ms 589d.5, Nr. 12a, mit eigenhändiger Antwort Lavaters, dat. 16.9.1775, und Nr. 14b, dat. 23.12.1775, nur Datum des Empfangs vorhanden)
description: Beilagen: 1 Brief an "alle Herren Buchhändler in der Schweiz und in Deutschland", dat. Zürich, 10.6.1773 (FA Lav Ms 589d.2, Nr. 4a); 1 Brief an Philipp Erasmus Reich, inkl. Abrechnung über die Totalauslage der Verlagsgesellschaft, dat. Oberrieden, 5.7.1773 (FA Lav Ms 589d.2, Nr. 6a); Krankengeschichte von Helene Juliana Karoline von Massenbach (FA Lav Ms 589d.3, Nr. 4a), vgl. hierzu auch Brief von H.J.K. von Massenbach in FA Lav Ms 519.266; zwei Paramythien "Der Blik" und "Die Mondfinsterniß" (FA Lav Ms 589d.4, Nr. 18)
26 Briefe, 19 Umschläge, 3 Beilagen an J[ohann] G[eorg] Zimmermann
Brief an Zimmermann ...
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1776

description: von Joh[ann] C[aspar] Lavater
description: Davon 1 Brief undatiert, nur Monat und Jahr des Empfangs vorhanden (FA Lav Ms 589e.1, Nr. 1)
description: Beilagen: 1 Blatt mit Titelvignetten-Entwurf für den 2. Band der Physiognomischen Fragmente in Bleistift (FA Lav Ms 589e.1, Nr. 1a); 1 Brief gedruckt an Freunde und Freundinnen, Gönner und Gönnerinnen, dat. 7.11.1776 (FA Lav Ms 589e.1, Nr. 15a); 1 Empfehlungsschreiben für Ziegler aus Zürich und Steiner aus Winterthur, dat. Zürich, 23.3.1778 (FA Lav Ms 589e.3, Nr. 2a)
description: Dabei 2 Briefe von Barbara Schulthess, dat. 10.2. und 20.3.1776 (FA Lav Ms 589e.1, Nr. 2a und Nr. 6b); 1 Brief von Johann Konrad Pfenninger, dat. 20.3.1776 (FA Lav Ms 589e.1, Nr. 6a); 1 Brief mit Umschlag von Anna Barbara von Muralt, dat. 24.3.1776, mit Notiz auf dem Umschlag, dat. Frankfurt, 30.3.1776, von Johann Konrad Deinet weitergeleitet an Zimmermann (FA Lav Ms 589e.1, Nr. 7)
description: Davon 1 Brief mitverfasst von Philipp Erasmus Reich, Friederike Louise Reich geb. Heyl, Anna Lavater, Johann Heinrich Steiner, Johann Jacob Zimmermann, (Samuel Clavel de Brenles durch Lavater) und Johannes Hotze (FA Lav Ms 589e.1, Nr. 10)
Aspects of the density field in an active nematic
Creators: name: Mishra, Shradha
name: Puri, Sanjay
name: Ramaswamy, Sriram
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Active nematics are conceptually the simplest orientationally ordered phase of self-driven particles, but have proved to be a perennial source of surprises. We show here through numerical solution of coarse-grained equations for order parameter and density that the growth of the active nematic phase from the isotropic phase is necessarily accompanied by a clumping of the density. The growth kinetics of the density domains is shown to be faster than the 1/3-law expected for variables governed by a conservation law. Other results presented include the suppression of density fluctuations in the stationary ordered nematic by the imposition of an orienting field. We close by posing some open questions.
description: 22 pages, 13 figures
Rubin LSST observing strategies to maximize volume and uniformity coverage of Star Forming Regions in the Galactic Plane
Creators: name: Prisinzano, L.
name: Bonito, R.
name: Mazzi, A.
name: Damiani, F.
name: Ustamujic, S.
name: Yoachim, P.
name: Street, R.
name: Guarcello, M. G.
name: Venuti, L.
name: Clarkson, W.
name: Jones, L.
name: Girardi, L.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A complete map of the youngest stellar populations of the Milky Way in the era of all-sky surveys, is one of the most challenging goals in modern astrophysics. The characterisation of the youngest stellar component is crucial not only for a global overview of the Milky Way structure, of the Galactic thin disk, and its spiral arms, but also for local studies. In fact, the identification of the star forming regions (SFRs) and the comparison with the environment in which they form are also fundamental to put them in the context of the surrounding giant molecular clouds and to understand still unknown physical mechanisms related to the star and planet formation processes. In 10 yrs of observations, Vera C. Rubin Legacy Survey of Space and Time (Rubin-LSST) will achieve an exquisite photometric depth that will allow us to significantly extend the volume within which we will be able to discover new SFRs and to enlarge the domain of a detailed knowledge of our own Galaxy. We describe here a metrics that estimates the total number of young stars with ages t < 10 Myr and masses >0.3M$_\odot$ that will be detected with the Rubin LSST observations in the gri bands at a 5 σ magnitude significance. We examine the results of our metrics adopting the most recent simulated Rubin-LSST survey strategies in order to evaluate the impact that different observing strategies might have on our science case.
description: 11 pages, 5 figures, 1 table; accepted for publication in The Astrophysical Journal Supplement Series
The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Creators: name: Bigler, Rebecca
name: Donohoe, Dallas R.
name: Collins, Leonard B.
name: Wali, Aminah
name: Bultman, Scott J.
name: Sun, Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Widespread changes in gene expression drive tumorigenesis, yet our knowledge of how aberrant epigenomic and transcriptome profiles arise in cancer cells is poorly understood. Here, we demonstrate that metabolic transformation plays an important role. Butyrate is the primary energy source of normal colonocytes and is metabolized to acetyl-CoA, which was shown to be important not only for energetics but also for HAT activity. Due to the Warburg effect, cancerous colonocytes rely on glucose as their primary energy source so butyrate accumulated and functioned as an HDAC inhibitor. Although both mechanisms increased histone acetylation, different target genes were upregulated. Consequently, butyrate stimulated the proliferation of normal colonocytes and cancerous colonocytes when the Warburg effect was prevented from occurring, whereas it inhibited the proliferation of cancerous colonocytes undergoing the Warburg effect. These findings link a common metabolite to epigenetic mechanisms that are differentially utilized by normal and cancerous cells because of their inherent metabolic differences.
Brouillard journalier nouveau de Lauffenbourg, appartenant à Perrollaz Cartier et Compagnie
Creators: name: Perrollaz, Cartier & Co
Publisher: name: [s.n.]
Year: 1808

description: Darin: Lose Einlage in separatem Umschlag; Register (Buchstaben B - X sind leer); Notizen ganz hinten
description: Französisch
description: Verzeichnung=Description=Inventaire 2014 ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Sebastian Preher
Photon collider Higgs factories
Creators: name: Telnov, V. I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The discovery of the Higgs boson (and still nothing else) have triggered appearance of many proposals of Higgs factories for precision measurement of the Higgs properties. Among them there are several projects of photon colliders (PC) without e+e- in addition to PLC based on e+e- linear colliders ILC and CLIC. In this paper, following a brief discussion of Higgs factories physics program I give an overview of photon colliders based on linear colliders ILC and CLIC, and of the recently proposed photon-collider Higgs factories with no e+e- collision option based on recirculation linacs in ring tunnels.
description: 15 pages, 8 figures, Latex. Talk at Int. conf. on instrumentation for colliding beam physics (INSTR 2014), Feb. 24 - March 1, 2014, BINP, Novosibirsk
Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth
Creators: name: Li, Tingting
name: Lin, Ruiting
name: Tao, Ren
name: Guan, Kun-Liang
name: Xiong, Yue
name: Lei, Qun-Ying
name: Zhou, Xin
name: Gao, Xue
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Increased fatty acid synthesis is required to meet the demand for membrane expansion of rapidly growing cells. ATP-citrate lyase (ACLY) is upregulated or activated in several types of cancer, and inhibition of ACLY arrests proliferation of cancer cells. Here we show that ACLY is acetylated at lysine residues 540, 546, and 554 (3K). Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and increases ACLY stability by blocking its ubiquitylation and degradation. Conversely, the protein deacetylase sirtuin 2 (SIRT2) deacetylates and destabilizes ACLY. Substitution of 3K abolishes ACLY ubiquitylation and promotes de novo lipid synthesis, cell proliferation, and tumor growth. Importantly, 3K acetylation of ACLY is increased in human lung cancers. Our study reveals a crosstalk between acetylation and ubiquitylation by competing for the same lysine residues in the regulation of fatty acid synthesis and cell growth in response to glucose.
The Hubble PanCET program: The near-ultraviolet transmission spectrum of WASP-79b
Creators: name: Gressier, A.
name: Etangs, A. Lecavelier des
name: Sing, D. K.
name: López-Morales, M.
name: Alam, M. K.
name: Barstow, J. K.
name: Bourrier, V.
name: Santos, L. A. Dos
name: Muñoz, A. García
name: Lothringer, J. D.
name: Nikolov, N. K.
name: Sotzen, K. S.
name: Henry, G. W.
name: Mikal-Evans, T.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present Hubble Space Telescope (HST) transit observations of the Hot-Jupiter WASP-79b acquired with the Space Telescope Imaging Spectrograph (STIS) in the near ultraviolet (NUV). Two transit observations, part of the PanCET program, are used to obtain the transmission spectra of the planet between 2280 and 3070Å. We correct for systematic effects in the raw data using the jitter engineering parameters and polynomial modelling to fit the white light curves of the two transits. We observe an increase in the planet-to-star radius ratio at short wavelengths, but no spectrally resolved absorption lines. The difference between the radius ratios at 2400 and 3000Å reaches $0.0191\pm0.0042$ ($\sim$4.5$-σ$). Although the NUV transmission spectrum does not show evidence of hydrodynamical escape, the strong atmospheric features are likely due to species at very high altitudes. We performed a 1D simulation of the temperature and composition of WASP-79b using Exo-REM. The temperature pressure profile crosses condensation curves of radiatively active clouds, particularly MnS, Mg$_2$SiO$_4$, Fe, and Al$_2$O$_3$. Still, none of these species produces the level of observed absorption at short wavelengths and can explain the observed increase in the planet's radius. WASP-79b's transit depth reaches 23 scale height, making it one of the largest spectral features observed in an exoplanet at this temperature ($\sim$1700 K). The comparison of WASP-79b's transmission spectrum with three warmer hot Jupiters shows a similar level of absorption to WASP-178b and WASP-121b between 0.2 and 0.3$μ$m, while HAT-P-41b's spectrum is flat. The features could be explained by SiO absorption.
description: Accepted for publication January 31, 2023 in the Journal Astronomy & Astrophysics
Study of the ability of Daphnia carinata King to control phytoplankton and resist cyanobacterial toxicity: implications for biomanipulation in Australia
Creators: name: Matveev, Vladimir
name: Matveeva, Lilian
name: Jones, Gary J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The properties of Daphnia carinata King as a grazer for use in biomanipulation trials were investigated. Mesocosm experiments suggested that in water from a lake where D. carinata was scarce, phytoplankton was nutrient-limited and the manipulated biomass of zooplankton had no effect on total chlorophyll a, whereas in water from a lake where D. carinata was dominant, nutrients were not limiting and total chlorophyll a was negatively correlated with the manipulated biomass of zooplankton. When offered lake phytoplankton in feeding trials, D. carinata consumed all items present, including colonies of cyanobacteria and long filaments of diatoms. In large outdoor tanks with natural plankton, the biovolume of prokaryotic ultraplankton (possible predecessors of cyanobacterial blooms) was consistently reduced in the presence of D. carinata. There was no evidence of an adverse effect of single-celled Microcystis aeruginosa containing the peptide toxin microcystin-LR on D. carinata grazing rates or survival. Different concentrations of microcystin-LR in solution covering the range of toxicities observed during M. aeruginosa blooms (5-500 nM) had no effect on D. carinata grazing. The suppression of phytoplankton biomass by D. carinata grazing is one of several possible mechanisms that might be considered for biomanipulation in Australia.
An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting
Creators: name: Wang, Gang Greg
name: Patel, Dinshaw J.
name: Xu, Bowen
name: Zheng, Deyou
name: Rockowitz, Shira
name: Strahl, Brian D.
name: Tripathy, Ashutosh
name: Lu, Rui
name: Cai, Ling
name: Rothbart, Scott B.
name: Allis, C. David
name: Chen, Wei-Yi
name: Song, Jikui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation and tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. However, the mechanisms that underlie PRC2 recruitment and spreading on chromatin remain unclear. Here we report that histone H3 lysine 36 trimethylation (H3K36me3)-binding activity is harbored in the Tudor motifs of PRC2-associated polycomblike (PCL) proteins PHF1/PCL1 and PHF19/PCL3. Ectopically expressed PHF1 induced Tudor-dependent stabilization of PRC2 complexes on bulk chromatin and mediated spreading of PRC2 and H3K27me3 into H3K36me3-containing chromatin regions. In murine pluripotent stem cells, we identified coexistence of H3K36me3, H3K27me3, and PHF19/PCL3 at a subset of ‘poised’ developmental genes, and demonstrated that PHF19/PCL3 Tudor function is required for optimal H3K27me3 and repression of these loci. Collectively, our data suggest that PCL recognition of H3K36me3 promotes intrusion of PRC2 complexes into active chromatin regions to promote gene silencing and modulate the chromatin landscape during development.
Implications of the primordial anisotropy for a scalar field with non-minimal kinetic coupling
Creators: name: Ghalee, Amir
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider a scalar field with a kinetic term non-minimally coupled to gravity in an anisotropic background. Various potentials for the scalar field are considered. By explicit examples, we show that how the anisotropy can change the dynamics of the scalar field compared with the isotropic background.
description: 11 pages; 1 figure
Variations in the stable isotope composition of aquatic plants and their implications for food web analysis
Creators: name: Boon, Paul I
name: Bunn, Stuart E
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The use of stable isotopes to identify the structure of aquatic food webs is predicted upon there being significant and consistent differences in the isotopic composition of the various classes of primary producers. The structure of food webs will be interpreted incorrectly if variations in the isotopic composition of primary producers are not taken into account. We detected significant temporal and spatial variations in the δ13C and δ15N values of aquatic plants collected from three small, lentic water bodies in south-eastern Australia. Carbon- and nitrogen- isotope values of individual taxa could each vary by up to 10 delta units, according to site and season. The magnitude of these variations is sufficiently great for them to have important consequences for the interpretation of aquatic food webs. Greater attention must be given to fluctuations in the isotopic signatures of the primary producers if the structure of aquatic food webs is to be properly understood.
Centromere Tethering Confines Chromosome Domains
Creators: name: Goodwin, Scott
name: Vasquez, Paula Andrea
name: Barry, Raymond Mario
name: Verdaasdonk, Jolien Suzanne
name: Forest, M. Gregory
name: Barry, Timothy
name: Bloom, Kerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The organization of chromosomes into territories plays an important role in a wide range of cellular processes including gene expression, transcription, and DNA repair. Current understanding has largely excluded the spatio-temporal dynamic fluctuations of the chromatin polymer. We combine in vivo chromatin motion analysis with mathematical modeling to elucidate the physical properties that underlie the formation and fluctuations of territories. Chromosome motion varies in predicted ways along the length of the chromosome, dependent on tethering at the centromere. Detachment of a tether upon inactivation of the centromere results in increased spatial mobility. A confined bead-spring chain tethered at both ends provides a mechanism to generate observed variations in local mobility as a function of distance from the tether. These predictions are realized in experimentally determined higher effective spring constants closer to the centromere. The dynamic fluctuations and territorial organization of chromosomes are, in part, dictated by tethering at the centromere.
Asymptotic behavior of solutions for linear parabolic equations with general measure data
Creators: name: Petitta, Francesco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper we deal with the asymptotic behavior as $t$ tends to infinity of solutions for linear parabolic equations whose model is $$ \begin{cases} u_{t}-Δu = μ& \text{in}\ (0,T)\timesΩ,\\[0.7 ex] u(0,x)=u_0 & \text{in}\ Ω, \end{cases} $$ where $μ$ is a general, possibly singular, Radon measure which does not depend on time, and $u_0\in L^{1}(Ω)$. We prove that the duality solution, which exists and is unique, converges to the duality solution (as introduced by G. Stampacchia) of the associated elliptic problem.
Search for Ultraheavy Dark Matter from Observations of Dwarf Spheroidal Galaxies with VERITAS
Creators: name: Acharyya, A.
name: Archer, A.
name: Bangale, P.
name: Bartkoske, J. T.
name: Batista, P.
name: Baumgart, M.
name: Benbow, W.
name: Buckley, J. H.
name: Falcone, A.
name: Feng, Q.
name: Finley, J. P.
name: Foote, G. M.
name: Fortson, L.
name: Furniss, A.
name: Gallagher, G.
name: Hanlon, W. F.
name: Hervet, O.
name: Hoang, J.
name: Holder, J.
name: Humensky, T. B.
name: Jin, W.
name: Kaaret, P.
name: Kertzman, M.
name: Kherlakian, M.
name: Kieda, D.
name: Kleiner, T. K.
name: Korzoun, N.
name: Krennrich, F.
name: Lang, M. J.
name: Lundy, M.
name: Maier, G.
name: McGrath, C. E
name: Moriarty, P.
name: O'Brien, S.
name: Ong, R. A.
name: Pfrang, K.
name: Pohl, M.
name: Pueschel, E.
name: Quinn, J.
name: Ragan, K.
name: Reynolds, P. T.
name: Roache, E.
name: Rodd, N. L.
name: Ryan, J. L.
name: Sadeh, I.
name: Saha, L.
name: Santander, M.
name: Sembroski, G. H.
name: Shang, R.
name: Splettstoesser, M.
name: Tak, D.
name: Tucci, J. V.
name: Vassiliev, V. V.
name: Williams, D. A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Dark matter is a key piece of the current cosmological scenario, with weakly interacting massive particles (WIMPs) a leading dark matter candidate. WIMPs have not been detected in their conventional parameter space (100 GeV $\lesssim M_χ \lesssim$ 100 TeV), a mass range accessible with current Imaging Atmospheric Cherenkov Telescopes. As ultraheavy dark matter (UHDM; $M_χ \gtrsim$ 100 TeV) has been suggested as an under-explored alternative to the WIMP paradigm, we search for an indirect dark matter annihilation signal in a higher mass range (up to 30 PeV) with the VERITAS gamma-ray observatory. With 216 hours of observations of four dwarf spheroidal galaxies, we perform an unbinned likelihood analysis. We find no evidence of a $γ$-ray signal from UHDM annihilation above the background fluctuation for any individual dwarf galaxy nor for a joint-fit analysis, and consequently constrain the velocity-weighted annihilation cross section of UHDM for dark matter particle masses between 1 TeV and 30 PeV. We additionally set constraints on the allowed radius of a composite UHDM particle.
description: 10 pages, 7 figures
A pilot study of vertical flow wetlands at Coffs Harbour, New South Wales, Australia
Creators: name: Chick, A. J
name: Mitchell, D. S
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

A modular series of vertical flow wetland (VFW) systems was established in 1989/90 to treat up to 130,000 litres per day of primary settled sewage on the north coast of New South Wales, Australia as an experimental scale-up of wetland microcosms that had been developed with this hydrological format. Monitoring of inflow and outflow water quality was maintained on a weekly basis from January 1991 to February 1992. Some management parameters (e.g. flow rates) were varied during this period. Dye injection to examine hydraulic behaviour within the gravel bed was carried out on two occasions in one VFW. in general the removal of nutrients was lower than expected, with between 20% and 40% reduction in concentrations and removal of loads over the year. Suspended solids and BOD removals were excellent, with a surprisingly good reduction in faecal coliform counts as well. Reduction in flow rates improved performance markedly in all parameters.
title: Femme et enfant Mwau
title: lu teene me ewa Mwau
Creators: name: Rivierre, Jean-Claude
Publisher: name: Pangloss
Year: 2022
Subjects: subject: Linguistique
subject: Cèmuhî

description: Mésaventures de la fillette restée à la maison pendant que sa mère est partie au bord de la mer pour ramasser des coquillages. La sorcière de l’endroit s’introduit auprès de la fillette, lui vole ses provisions et oblige l’enfant à rentrer dans son ventre. À la fin de la journée, l’enfant ressort et raconte tout à sa mère. La même scène se répète le lendemain, et encore une fois le surlendemain. Mais cette fois la fillette reste enfermée dans le ventre de la sorcière après lui avoir cousu le derrière. Il ne reste plus à la mère qu’à fracasser le crâne de la sorcière et à libérer sa fille. La mère et l’enfant mettent la sorcière au four et la mangent.
title: Presentazione. Un pensiero aperto al presente
Creators: name: Dovolich , Claudia
Publisher: name: Roma Tre-Press
Year: 2011

description: I saggi che sono qui raccolti consentono di in-con-tra-re attraverso il pensiero di Jean-Luc Nancy alcune delle questioni più urgenti che il nostro tempo ha da ri-pensare. Infatti, rispondendo a tutti e a ciascuno, Nancy instancabilmente rilancia l'apertura della riflessione filosofica sugli interrogativi che da sempre ci inquietano, ci meravigliano, ma soprattutto ci convocano dinanzi a «signolari decisioni d'esistenza» riaffermando in ogni circostanza il forte carattere etico-politico che fin dai primi scritti caratterizza il suo singolare modo di fare filosofia.

description: B@belonline vol. 10/11 Pensare con Jean-Luc Nancy
Integral Nuclear Pore Proteins Bind to Pol III-Transcribed Genes and Are Required for Pol III Transcript Processing in C. elegans
Creators: name: Ikegami, Kohta
name: Lieb, Jason D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Nuclear pores associate with active protein-coding genes in yeast and have been implicated in transcriptional regulation. Here, we show that in addition to transcriptional regulation, key components of C. elegans nuclear pores are required for processing of a subset of small nucleolar RNAs (snoRNAs) and tRNAs transcribed by RNA Polymerase (Pol) III. Chromatin immunoprecipitation of NPP-13 and NPP-3, two integral nuclear pore components, and importin-β IMB-1, provides strong evidence that this requirement is direct. All three proteins associate specifically with tRNA and snoRNA genes undergoing Pol III transcription. These pore components bind immediately downstream of the Pol III pre-initiation complex, but are not required for Pol III recruitment. Instead, NPP-13 is required for cleavage of tRNA and snoRNA precursors into mature RNAs, whereas Pol II transcript processing occurs normally. Our data suggest that integral nuclear pore proteins act to coordinate transcription and processing of Pol III transcripts in C. elegans.
Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
Creators: name: Guan, Kun-Liang
name: Zhao, Di
name: Xiong, Yue
name: Xu, Yan-Ping
name: Wang, Wei
name: Zhou, Xin
name: Sasaki, Naoya
name: Li, Ting-Ting
name: Jiang, Ying
name: Lv, Lei
name: Lei, Qun-Ying
name: Li, Fu-Long
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Alternative splicing of the PKM2 gene produces two isoforms, M1 and M2, which are preferentially expressed in adult and embryonic tissues, respectively. The M2 isoform is reexpressed in human cancer and has nonmetabolic functions in the nucleus as a protein kinase. Here, we report that PKM2 is acetylated by p300 acetyltransferase at K433, which is unique to PKM2 and directly contacts its allosteric activator, fructose 1,6-bisphosphate (FBP). Acetylation prevents PKM2 activation by interfering with FBP binding and promotes the nuclear accumulation and protein kinase activity of PKM2. Acetylationmimetic PKM2(K433) mutant promotes cell proliferation and tumorigenesis. K433 acetylation is decreased by serum starvation and cell-cell contact, increased by cell cycle stimulation, epidermal growth factor (EGF), and oncoprotein E7, and enriched in breast cancers. Hence, K433 acetylation links cell proliferation and transformation to the switch of PKM2 from a cytoplasmic metabolite kinase to a nuclear protein kinase.
title: The Effects of Low Doses (1 to 500 Kilograys) of 100-KEV Electrons on Four Polymers
Creators: name: Bradbury, Cynthia Anne
Publisher: name: Old Dominion University Libraries
Year: 1988

description: Commercial films of polyetherimide (PEI), polyetheretherimide (PEEI), polyethylene terephthalate (PET), and polycarbonate (PC) were exposed in vacuum to l 00-keV electron radiation to total absorbed doses of l, l 0, l 00, 300, and 500 kilograys. The concentration of radiation-generated radicals, as measured by electron paramagnetic resonance (EPR), increased by over an order of magnitude in all four polymers. Correspondingly, the intensity of the infrared absorption peaks increased uniformly for all doses. Solubility tests resulted in decreased solubility in all polymers. IR, EPR, and solubility suggest dehydrogenation of the aliphatic C-H and phenyl C-H sites. The data indicated that cross linking is occurring in all polymers tested.
Optomechanics-based quantum estimation theory for collapse models
Creators: name: Marchese, Marta Maria
name: Belenchia, Alessio
name: Paternostro, Mauro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We make use of the powerful formalism of quantum parameter estimation to assess the characteristic rates of a Continuous Spontaneous Localisation (CSL) model affecting the motion of a massive mechanical system. We show that a study performed in non-equilibrium conditions unveils the advantages provided by the use of genuinely quantum resources -- such as quantum correlations -- in estimating the CSL-induced diffusion rate. In stationary conditions, instead, the gap between quantum performance and a classical scheme disappears. Our investigation contributes to the ongoing effort aimed at identifying suitable conditions for the experimental assessment of collapse models.
description: 7 pages, 3 figures
Nutrient Sensing, Metabolism, and Cell Growth Control
Creators: name: Guan, Kun-Liang
name: Xiong, Yue
name: Yuan, Hai-Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations. AMP activated kinase and mammalian target of rapamycin complex 1 serve as key molecules that sense cellular energy and nutrients levels, respectively. In addition, the dioxygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, has emerged as possible sensors of intracellular metabolic status. The interplay among nutrients, metabolites, gene expression, and protein modification are involved in the coordination of cell growth with extracellular and intracellular conditions.
Zitterbewegung in monolayer silicene in a magnetic field
Creators: name: Romera, E.
name: Roldán, J. B.
name: Santos, F. de los
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the Zitterbewegung in monolayer silicene under a perpendicular magnetic field. Using an effective Hamiltonian, we have investigated the autocorrelation function and the density currents in this material. Moreover, we have analyzed other types of periodicities of the system (classical and revival times). Finally, the above results are compared with their counterparts in two other monolayer materials subject to a magnetic field: graphene and MoS$_2$
Protons as Second Messenger Regulators of G Protein Signaling
Creators: name: Smalley, David M.
name: Isom, Daniel G.
name: Clement, Sarah T.
name: Baker, Rachael
name: Dohlman, Henrik G.
name: Sridharan, Vishwajith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: In response to environmental stress cells often generate pH signals that serve to protect vital cellular components and reprogram gene expression for survival. A major barrier to our understanding of this process has been the identification of signaling proteins that detect changes in intracellular pH. To identify candidate pH sensors we developed a computer algorithm that searches proteins for networks of proton-binding sidechains. This analysis indicates that Gα subunits, the principal transducers of G protein-coupled receptor signals, are pH sensors. Our structure-based calculations and biophysical investigations reveal that Gα subunits contain networks of pH-sensing sidechains buried between their Ras and helical domains. We show further that proton binding induces changes in conformation that promote Gα phosphorylation and suppress receptor-initiated signaling. Together, our computational, biophysical and cellular analyses reveal a new and unexpected function for G proteins as mediators of stress-response signaling.