Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
Creators: name: Zhao, Jing Hua
name: Mosley, Thomas H.
name: Atwood, Larry
name: Falusi, Adeyinka G.
name: Conti, David V.
name: Schurmann, Claudia
name: Schreiner, Pamela J.
name: Signorello, Lisa B.
name: Hirschhorn, Joel N.
name: Haiman, Christopher A.
name: North, Kari E.
name: Papanicolaou, George
name: Nemesure, Barbara
name: Tucker, Margaret A.
name: Bottinger, Erwin P.
name: Zhi, Degui
name: Wang, Zhaoming
name: Kolb, Suzanne
name: Hsu, Yu-Han H.
name: Monda, Keri L.
name: Siscovick, David S.
name: Ojengbede, Oladosu
name: Irvin, Marguerite R.
name: Rao, D.C.
name: Zonderman, Alan B.
name: Moore, Jason H.
name: Fornage, Myriam
name: Ruiz-Narvaez, Edward A.
name: Johnson, Karen C.
name: Manson, JoAnn E.
name: Coetzee, Gerry A.
name: Burke, Gregory
name: Wilson, James G.
name: Rohde, Rebecca
name: Haritunians, Talin
name: Ziegler, Regina G.
name: N’Diaye, Amidou
name: Carpten, John
name: Goodman, Phyllis
name: Nathanson, Katherine L.
name: Sun, Yan V.
name: Liu, Yongmei
name: Zakai, Neil
name: Feitosa, Mary F.
name: Chesi, Alessandra
name: Bartz, Traci
name: Palmer, Nicholette D.
name: Grant, Struan F.A.
name: Blot, William J.
name: Ambs, Stefan
name: Allison, Matthew A.
name: Howard, Timothy D.
name: Smith, Shad
name: Press, Michael F.
name: Hsing, Ann W.
name: Wrensch, Margaret
name: Neuhouser, Marian L.
name: Meng, Yan
name: Zhu, Xiaofeng
name: Arnett, Donna K.
name: Salako, Babatunde
name: Broeckel, Ulrich
name: Nalls, Mike A.
name: Liu, Simin
name: Olopade, Olufunmilayo I.
name: Kooperberg, Charles
name: Psaty, Bruce M.
name: Liu, Ching-Ti
name: Padhukasahasram, Badri
name: Bandera, Elisa V.
name: Zhang, Xinruo
name: Harris, Curtis C.
name: Thun, Michael J.
name: Palmer, Cameron D.
name: Tayo, Bamidele O.
name: Rhie, Suhn K.
name: Cooper, Richard S.
name: Faul, Jessica D.
name: McNeill, Lorna Haughton
name: Freedman, Barry I.
name: Schwartz, Ann G.
name: Zemel, Babette S.
name: Chen, Minhui
name: Singleton, Andrew B.
name: Rybicki, Benjamin A.
name: Spitz, Margaret
name: Kittles, Rick A.
name: Amos, Christopher
name: Neslund-Dudas, Christine
name: Bowden, Donald W.
name: Adeyemo, Adebowale A.
name: Hu, Jennifer J.
name: Monroe, Kris
name: Lettre, Guillaume
name: Maixner, William
name: Liu, Youfang
name: Carlson, Chris
name: Kutlar, Abdullah
name: Sanderson, Maureen
name: Hennis, Anselm
name: Loos, Ruth
name: Cade, Brian E.
name: Vaidya, Dhananjay
name: Yao, Jie
name: Buchanan, Victoria
name: Casey, Graham
name: Langefeld, Carl D.
name: Fox, Caroline
name: Demerath, Ellen
name: Jordan, Joanne M.
name: Reiner, Alex P.
name: Witte, John S.
name: Kang, Sun J.
name: Zmuda, Joe
name: Peyser, Patricia A.
name: Vedantam, Sailaja
name: Becker, Diane M.
name: Young, Kristin L.
name: Nayak, Uma
name: Zhou, Jie
name: Chen, Guanjie
name: Howard, Barbara
name: Speliotes, Elizabeth
name: Leonard, Hampton
name: Nyante, Sarah
name: Fine, Rebecca S.
name: Murphy, Adam B.
name: Diver, W. Ryan
name: Chiang, Charleston W.K.
name: Sale, Michele M.
name: Cushman, Mary
name: Huo, Dezheng
name: Lohman, Kurt
name: Strom, Sara S.
name: Olshan, Andrew
name: Borecki, Ingrid B.
name: Palmer, Julie
name: Taylor, Kira
name: Deming, Sandra L.
name: Garcia, Melissa
name: Keating, Brendan J.
name: Graff, Mariaelisa
name: Caporaso, Neil
name: Henderson, Brian E.
name: Lim, Elise
name: Shriner, Daniel A.
name: Shao, Yaming
name: Ogundiran, Temidayo O.
name: Zhao, Wei
name: Rodriguez-Gil, Jorge L.
name: Bernstein, Leslie
name: Chen, Yii-Der I.
name: Redline, Susan
name: Wiencke, John K.
name: Bradfield, Jonathan P.
name: Stanford, Janet L.
name: Huff, Chad D.
name: Pettaway, Curtis A.
name: Levin, Albert M.
name: Wassertheil-Smoller, Sylvia
name: Marouli, Eirini
name: Evans, Michele K.
name: Lange, Leslie
name: Schadt, Eric
name: Ng, Maggie C.Y.
name: Cai, Qiuyin
name: Kabagambe, Edmond K.
name: Wojczynski, Mary K.
name: Hernandez, Dena G.
name: Van Den Berg, David J.
name: Chanock, Stephen J.
name: Le Marchand, Loic
name: Williams, L. Keoki
name: Lu, Yingchang
name: Zheng, Wei
name: Vitolins, Mara
name: Ding, Jingzhong
name: Berndt, Sonja I.
name: Patel, Sanjay R.
name: Ingles, Sue A.
name: Mudgal, Poorva
name: Justice, Anne E.
name: Hakonarson, Hakon
name: Klein, Eric A.
name: Rotter, Jerome I.
name: Stram, Alex
name: John, Esther M.
name: Kardia, Sharon L.
name: Ochs-Balcom, Heather
name: Taylor, Herman
name: Duan, Qing
name: Chu, Lisa
name: Li, Jin
name: Ware, Erin B.
name: Gottesman, Omri
name: Lotay, Vaneet
name: Sucheston, Lara
name: Smith, Jennifer A.
name: Bielak, Lawrence F.
name: Ambrosone, Christine B.
name: Dimitrov, Latchezar
name: Tajuddin, Salman M.
name: McKnight, Barbara
name: Gillanders, Elizabeth M.
name: Rotimi, Charles N.
name: Kuller, Lewis
name: Brody, Jennifer A.
name: Rasmussen-Torvik, Laura J.
name: Ogunniyi, Adesola
name: Rand, Kristin
name: Yanek, Lisa R.
name: Chen, Wei-Min
name: Okut, Hayrettin
name: Guo, Xiuqing
name: Li, Yun
name: Kolonel, Laurence N.
name: Williams, Scott M.
name: Aldrich, Melinda C.
name: Harris, Tamara B.
name: Stevens, Victoria L.
name: Cupples, L. Adrienne
name: Wu, Xifeng
name: Zanetti, Krista
name: Nadukuru, Rajiv
name: Weir, David R.
Publisher: name: Elsevier
Year: 2021

description: <p>Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). We additionally combined our African ancestry meta-analysis results with published European genome-wide association study (GWAS) data. In the African ancestry analyses, we identified three novel loci (SLC4A3, NCOA2, ECD/FAM149B1) in sex-combined results and two loci (CRB1, KLF6) in women only. In the African plus European sex-combined GWAS, we identified an additional three novel loci (RCCD1, G6PC3, CEP95) which were equally driven by AAAGC and European results. Among 39 genome-wide significant signals at known loci, conditioning index SNPs from European studies identified 20 secondary signals. Two of the 20 new secondary signals and none of the 8 novel loci had minor allele frequencies (MAF) &lt; 5%. Of 802 known European height signals, 643 displayed directionally consistent associations with height, of which 205 were nominally significant (p &lt; 0.05) in the African ancestry sex-combined sample. Furthermore, 148 of 241 loci contained &le;20 variants in the credible sets that jointly account for 99% of the posterior probability of driving the associations. In summary, trans-ethnic meta-analyses revealed novel signals and further improved fine-mapping of putative causal variants in loci shared between African and European ancestry populations.</p>