cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Antinuclear antibodies and connectivitis
title: Anticorps antinucléaire et connectivites
Creators: name: Kaoutar Ouazahrou
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2022
Subjects: Autoanticorps; Maladies auto-immunes; Maladies du tissu conjonctif; Immunofluorescence indirecte

description: Antinuclear antibodies (ANAs) are a spectrum of autoantibodies targeted to various nuclear and cytoplasmic components of the cells. They are very useful as serological markers for different autoimmune disease, like systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), scleroderma, polymyositis, or mixed connective tissue disease. Antinuclear antibodies react with various nuclear autoantigens. Testing for them is critical for diagnosing connective tissue diseases, but they may be also found in other inflammatory diseases and in the elderly. They constitute a group of heterogeneous autoantibodies, and their specificity helps to discriminate between various connective tissue diseases. Screening for total antinuclear antibodies is generally performed by indirect immunofluorescence on HEp2 cells. In the presence of antinuclear antibodies, anti-dsDNA antibodies and anti-ENA (extractable nuclear antigens) antibodies must be sought.
description: Les anticorps antinucléaires (ANA) sont un spectre d’auto-anticorps ciblant divers composants nucléaires et cytoplasmiques des cellules. Ils sont très utiles en tant que marqueurs sérologiques pour différentes maladies auto-immunes, comme le lupus érythémateux disséminé (LED), le syndrome de Sjögren (SS), la sclérodermie, la polymyosite ou la maladie mixte du tissu conjonctif. Les anticorps antinucléaires réagissent avec divers autoantigènes nucléaires. Leur dépistage est essentiel pour diagnostiquer les maladies du tissu conjonctif, mais ils peuvent également être trouvés dans d’autres maladies inflammatoires et chez les personnes âgées. Ils constituent un groupe d’auto-anticorps hétérogènes, et leur spécificité aide à distinguer les différentes maladies du tissu conjonctif. Le dépistage des anticorps antinucléaires totaux est généralement effectué par immunofluorescence indirecte sur les cellules HEp2. En présence d’anticorps antinucléaires, des anticorps anti-ADNdb et des anticorps anti-ENA (antigènes nucléaires extractibles) doivent être recherchés.
Desenvolupament d'un entorn per a l'anàlisi, transformaciò i síntesi de sons usant la llibreria CLAM
Creators: name: Mora, Albert
Publisher: name: Zenodo
Year: 2003

description: Aquesta ´es la mem`oria on es recull la feina que ha fet l’Albert Joaquim Mora i Puyal per a les assignatures Sistemes Inform`atics I i Sistemes Inform`atics II, en concepte de Projecte de Final de Carrera, de l’Enginyeria en Inform`atica, especialitzada en Comunicaci´o, de la Universitat Pompeu Fabra. El director del projecte ha estat en Xavier Amatriain Rubio. Aquest projecte neix amb la idea de fer una versi´o demostraci´o, fonamentada en la llibreria CLAM (C++ Library for Audio and Music, [Musa]), de la t`ecnica SMS (Spectral Modeling Sinthesis, iniciada per Xavier Serra a la seva tesi doctoral[Ser89a], [Musc]). La t`ecnica SMS, basada en models espectrals, ´es una t`ecnica usada `ampliament en el si dels projectes que es duen a terme dins el Grup de Tecnologia Musical (MTG, [Musb]), grup de recerca destacat per la seva investigaci´o sobre les tecnologies de processament d’`audio i les seves aplicacions musicals i multim`edia. A partir dels treballs inicials en el desenvolupament d’aquests models espectrals, l’MTG centra la seva atenci´o en la s´ıntesi de so, el processament d’`audio basat en el contingut, i altres temes relacionats amb la Tecnologia Musical
MPEC 2024-E52 : 2007 EN
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Genomic and metabolomic studies for better understanding of osteoarthritis pathogenesis
Creators: name: Werdyani, Salem
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: Osteoarthritis is the most common form of arthritis and one of the ten most disabling diseases in developed countries. The main objective of my thesis was to employ genomic and metabolomic approaches to improve our understanding of the OA pathogenesis. I carried out a metabolomics analysis and identified three distinct endotypes of OA patients. Butyrylcarnitine, arginine, and a number of glycerophosphlipids were the major contributing metabolites for the differentiation between the three endotypes suggesting that the primary OA patients can be classified as muscle weakness, arginine deficient, and low inflammatory OA. Using the same metabolomics approach, I found that the elevated blood level of the ADMA and uric acid were associated with the muscle weakness over 10-years and may elevate the study participants risk for developing OA. Additionally, I conducted an independent GWAS analysis in OA patients from NL and identified novel genes significantly associated with OA. These genes are involved in cartilage deterioration; inflammatory signaling; innate immune pathway; abnormal bone growth and remodeling; panic disorder; and pain mechanisms. Further, I performed a genetic variant annotation study using WES data and identified deleterious variants in the IGSF3, ZNF717, PRSS1, AQP7, and ESRRA genes in OA patients that have not been reported in previous OA GWAS studies. These genes act in the ECM homeostasis and degradation. With the same WES data, I conducted a genome wide digenic interaction test in OA patients and identified aggregated variants in each of the CDH19, SOGA1, MORC4, TMTC4, and ANK3 genes to be significantly interacting with rs56158521 in the HLA-DRB1 gene. Our findings suggested the implication of the immunoinflammatory pathway in the pathogenesis of OA. Also, I conducted a GWAS analysis and found variants in the MC5R gene to be significantly increasing the TJR pain, and variants adjacent to the TPTE gene to be significantly increasing the TJR disability. These genes are involved in immunoinflammatory reactions and may play a significant role in the pain and function mechanisms following TJR. While confirmation is required, these findings provided new insights into better understanding of the OA pathogenesis and hold promising as druggable targets for developing OA therapies.
Database-Driven Systems and Applications for Music Information Management
Creators: name: Wüst, Otto
Publisher: name: Zenodo
Year: 2003

description: Many scientific and technical developments in recent years have lead to a situation where moderately large collections of multimedia data, in particular of musical data, are available to computer users, who start to demand new applications that can go beyond the traditional file system based data management. This work analyzes the problems and scientific contributions in the field of music information retrieval, specifically focusing on database related issues and applications, to establish the state of the art. Furthermore, and due to the character of research retrospective, this document reviews some of the author’s work in the area of music and database applications, including the implementation of an MPEG-7 database layer, a crawler system which gathers musical information of web pages that is then used to construct a cultural similarity measure, and a database driven architecture for collaborative collective composition on the web. Finally, conclusions are drawn and some research problems that constitute the author’s interest for future work are exposed.
title: A decade of assessment reform in Ireland: Context, common facets, and culture. An exploration of the Primary Curriculum Framework (2023) and the Framework for Junior Cycle (2015)
Creators: name: Tuohy, Sinéad
name: Sullivan, Patrick
name: Behan, Johm
name: Curran, Tracy
name: O' Sullivan, Gerard
Publisher: name: La Revue LEeE
Year: 2024
Subjects: assessment
teaching and learning
conducive conditions
policy development
stakeholder engagement

description: Assessment policy and practice is a key cornerstone of education and a significant influence on teaching and learning, and on learner outcomes. This paper provides insights into recent assessment reforms in Ireland which have sought to reposition assessment in both primary and lower secondary education as part of broader curriculum change. It provides an overview of the prevailing assessment landscape prior to these reforms and explores the associated assessment culture that has evolved over time thereby providing a rich picture of the context for these reforms. Taking the two core policy documents at the heart of the reforms, the Primary Curriculum Framework (2023) and the Framework for Junior Cycle (2015), it identifies four common facets that underpin assessment, before then providing insights into the process of developing education policy advice and how this is shaped not only by research but also by the key education stakeholders. Based on the lived experience of these recent reforms, this paper identifies some key factors that have been identified as contributing towards and conspiring against the successful implementation of a new vision for assessment. The paper concludes with a reflection on assessment policy as a driver of education reform.
Charge transport in chiral solids as a possible tool in search of dark matter signals
Creators: name: Rogatko, Marek
name: Wysokinski, Karol
Publisher: name: Zenodo
Year: 2023

description: Calculations and descriptions used in article:

Charge transport in chiral solids as a possible tool in search of dark matter signals-Phys.Rev. D108, 104062 (2023),

Marek Rogatko, Karol Wysokinski
Reduced Exports to China in Fiscal Year 2019 May Drive U.S. Agricultural Trade Balance to Lowest Level Since 2007
Creators: name: Melton, Alex
name: Cooke, Bryce
name: Melton, Alex
name: Cooke, Bryce
Publisher: name: Unknown
Year: 2018
Subjects: subject: Agricultural and Food Policy
subject: Demand and Price Analysis
subject: International Development
subject: International Relations/Trade
subject: agricultural
subject: exports
subject: trade
subject: China

description: The projected value of U.S. agricultural exports in the 2019 fiscal year is expected to decline relative to 2018, while import value is projected to rise. If realized, these projections indicate that the U.S. agricutural trade surplus will be the lowest since 2007.
title: Uveitis in juvenile idiopathic arthritis (JIA) in practice : diagnosis and follow-up
title: Les uvéites au cours des arthrites juvéniles idiopathiques (AJI) en pratique : diagnostic et suivi.
Creators: name: Bouayad, Sara
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2022
Subjects: Arthrite juvénile idiopathique; Uvéite; Diagnostic; Traitement.

description: Juvenile idiopathic arthritis (JIA) is the most common inflammatory disease affecting children. Uveitis in JIA is a major complication that can cause severe visual acuity or even blindness. This severity is due partly to the delay in diagnosis and treatment, as they are most often insidious, with generally little or without symptoms. Therefore, a better understanding of the risk factors causing the occurrence of uveitis should allow for an early as well as an appropriate screening and management and as a consequence improve the visual prognosis. Screening should be done as soon as the diagnosis of JIA is made. It is mainly based on a slit lamp examination. Recurrent or chronic acute anterior uveitis are most commonly observed. It can be bilateral from the start or become as such in the majority of cases [1]. The follow-up of these uveitis, in terms of frequency and duration depends on the JIA form, the severity of the uveitis, the age at diagnosis, and the response to treatment. The objective of this work is to focus on the specificities of uveitis associated with JIA (JIA-U), the diagnosis modalities as well as the frequency and duration of the follow-up.
description: L’arthrite juvénile idiopathique (AJI) est le rhumatisme inflammatoire le plus fréquent de l’enfant. L’uvéite survenant au cours des AJI est une complication sévère pouvant être à l’origine d’une baisse importante de l’acuité visuelle, voire d’une cécité. Cette gravité est due en partie au retard diagnostic et thérapeutique vu qu’elles sont le plus souvent insidieuses, en général peu ou pas symptomatiques. Par conséquent, une meilleure connaissance des facteurs de risque de survenue de l’uvéite doivent permettre un dépistage et une prise en charge précoces et adaptés afin d’améliorer le pronostic visuel. Le dépistage doit être fait dès que le diagnostic de l’AJI est posé. Il repose principalement sur un examen à la lampe à fente. L’atteinte observée est le plus souvent une uvéite antérieure aigue récidivante ou chronique. Elle peut être bilatérale d’emblée ou le devenir dans la majorité des cas [1]. Le rythme et la durée de suivi de ces uvéites dépendent de la forme de l’AJI, de la gravité de l’uvéite, de l’âge au diagnostic ainsi que la réponse au traitement. L’objectif de ce travail est de mettre le point sur les particularités des uvéites associées aux AJI (AJI-U), les modalités diagnostiques ainsi que la fréquence et la durée du suivi de ces uvéites.
Database-Driven Systems and Applications for Music Information Management
Creators: name: Janer, Jordi
Publisher: name: Zenodo
Year: 2004

description: The aim of this document is to explore the singing voice as a valid musical controller for real-time synthesis. We address the identification and extraction of the voice features, and the mapping of those features to a synthesis engine. Since the advent of digital music synthesis and MIDI, many controllers have been developed, ranging from the traditional keyboard to sophisticated computer vision systems. We propose to employ an ubiquitous and highly expressive instrument the voice. This work first reviews aspects of voice analysis, and the control of different synthesis techniques. Finally, we present a prototype of {\em Vocal Controller} that synthesizes a bass guitar using two techniques Physical Models and Spectral Models. The proposal for the PhD dissertation consists of extending the current prototype, allowing for real-time performance situations; and validating the system with two groups of subjects naive users and skilled musicians.
Agricultural company and agricultural holding towards climate and agricultural policy changes (2)
Creators: name: Abramczuk, Łukasz
name: Chlebicka, Aleksandra
name: Czułowska, Magdalena
name: Jabłoński, Konrad
name: Józwiak, Wojciech
name: Sobierajewska, Jolanta
name: Skarżyńska, Aldona
name: Zieliński, Marek
name: Ziętara, Wojciech
name: Żekało, Marcin
name: Józwiak, Wojciech (Ed.)
name: Abramczuk, Łukasz
name: Chlebicka, Aleksandra
name: Czułowska, Magdalena
name: Jabłoński, Konrad
name: Józwiak, Wojciech
name: Sobierajewska, Jolanta
name: Skarżyńska, Aldona
name: Zieliński, Marek
name: Ziętara, Wojciech
name: Żekało, Marcin
name: Józwiak, Wojciech (Ed.)
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: agricultural farms
subject: agricultural holdings
subject: agricultural products
subject: climate changes
subject: economic changes
subject: farms
subject: fruit
subject: fruit growers
subject: gross margin
subject: horticultural holdings
subject: Poland
subject: producer groups
subject: vegetable

description: It is the second of a series of five publications devoted to operation of national agricultural holdings in the conditions of climate change and expected change in the agricultural policy that can take place in 2021 and its further implementation in the next years. Chapters: Semi-subsistence agricultural holdings towards climate and economic changes. Agricultural farms from the LFA as compared to other farms. Effectiveness of Polish horticultural holdings against a background of similar holdings from the selected countries. Fruit and vegetable producer groups and organisations as a method of improving the competitive position of fruit growers in Poland. Gross margin from selected agricultural products – regional approach.
Mutated form (G52E) of inactive diphtheria toxin CRM197: molecular simulations clearly display effect of the mutation to NAD binding
Creators: name: Salmas, Ramin Ekhteiari
name: Mestanoglu, Mert
name: Unlu, Ayhan
name: Yurtsever, Mine
name: Durdagi, Serdar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Mutated form (G52E) of diphtheria toxin (DT) CRM197 is an inactive and nontoxic enzyme. Here, we provided a molecular insight using comparative molecular dynamics (MD) simulations to clarify the influence of a single point mutation on overall protein and active-site loop. Post-processing MD analysis (i.e. stability, principal component analysis, hydrogen-bond occupancy, etc.) is carried out on both wild and mutated targets to investigate and to better understand the mechanistic differences of structural and dynamical properties on an atomic scale especially at nicotinamide adenine dinucleotide (NAD) binding site when a single mutation (G52E) happens at the DT. In addition, a docking simulation is performed for wild and mutated forms. The docking scoring analysis and docking poses results revealed that mutant form is not able to properly accommodate the NAD molecule.
SCORES technical poster
Creators: name: Colantonio, Petra
Publisher: name: Zenodo
Year: 2020
Subjects: Energy storage
Energy efficiency
Renewable energy

description: SCORES project combines and optimizes the multi-energy generation, storage and consumption of local renewable energy (electricity and heat) and grid supply, bringing new sources of flexibility to the grid, and enabling reliable operation with a positive business case in Europe’s building stock. Technical poster was created for the participation at workshop "Save today, use tomorrow" organized within the World Sustainable Energy days conference on 28th February 2019 in Wels, Austria.
Living in a world of biased search engines
Creators: name: Lewandowski, Dirk
Publisher: name: figshare
Year: 2016
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications
subject: 80704 Information Retrieval and Web Search

description: Search engines are always biased, and there is no such thing as an unbiased search engine. It would be impossible to construct such a search engine, because human beliefs and assumptions influence the design of algorithms, and they therefore prefer certain documents to others. It is even at the core of every idea of ranking that, based on certain technically mediated assumptions, certain items are preferred over others.
Towards computational morphological description of sound
Creators: name: Ricard, Julien
Publisher: name: Zenodo
Year: 2004

description: Research on audio content description deals with limited types of sounds. Most of the work done in this area is applied to automatic transcription of traditional western music, i.e. the conversion of audio into the traditional musical notation pitch/duration/loudness/source or the recognition of the origin of specific sounds (speech, music, applause...) for indexing or retrieval purpose. In that context, electronic sounds, noises or sounds that have no identifiable origin, which are used a lot in contemporary music and sound post production for video or cinema, can hardly be handled. In this document, we propose an alternative representation, inspired by Pierre Schaeffer's work on sound objects, based on a limited number of perceptual criteria that can be applied to any type of sound. More specifically, we describe our first attempt to automatically characterize some of these criteria, called morphological criteria, as well as an evaluation of the usability of the resulting representation in the context of sound retrieval. Conclusions drawn from these experiments to improve and complete the system, as well as a the description of potential applications, are presented as future work to be done in the final thesis.
I-Optimal Design of Mixture Experiments
Creators: name: Goos, Peter
name: Jones, Bradley
name: Utami Syafitri
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Hematology
subject: Plant Biology

description: In mixture experiments, the factors under study are proportions of the ingredients of a mixture. The special nature of the factors necessitates specific types of regression models, and specific types of experimental designs. Although mixture experiments usually are intended to predict the response(s) for all possible formulations of the mixture and to identify optimal proportions for each of the ingredients, little research has been done concerning their I-optimal design. This is surprising given that I-optimal designs minimize the average variance of prediction and, therefore, seem more appropriate for mixture experiments than the commonly used D-optimal designs, which focus on a precise model estimation rather than precise predictions. In this article, we provide the first detailed overview of the literature on the I-optimal design of mixture experiments and identify several contradictions. For the second-order and the special cubic model, we present continuous I-optimal designs and contrast them with the published results. We also study exact I-optimal designs, and compare them in detail to continuous I-optimal designs and to D-optimal designs. One striking result of our work is that the performance of D-optimal designs in terms of the I-optimality criterion very strongly depends on which of the D-optimal designs is considered. Supplemental materials for this article are available online.
New approaches for rhythmic description of audio signals
Creators: name: Guaus, Enric
Publisher: name: Zenodo
Year: 2004

description: The subject of this work is the study of how rhythmical description of music can be included in Music Information Retrieval works, but from a more musical point of view. The goal is to provide a suitable representation of rhythm and explore how useful it can be for many different applications. This new representation is based on the so called Rhythm Transform that transforms data from the time domain to a so called rhythm domain. This transformation has proved to give good results for automatic classification and similarity applications. The theoretical and computational issues of the Rhythm Transform are explained, and some results for specific applications are also shown.
I-optimal design of mixture experiments
Creators: name: Goos, Peter
name: Jones, Bradley
name: Utami Syafitri
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Hematology
subject: Plant Biology

description: In mixture experiments, the factors under study are proportions of the ingredients of a mixture. The special nature of the factors necessitates specific types of regression models, and specific types of experimental designs. Although mixture experiments usually are intended to predict the response(s) for all possible formulations of the mixture and to identify optimal proportions for each of the ingredients, little research has been done concerning their I-optimal design. This is surprising given that I-optimal designs minimize the average variance of prediction and, therefore, seem more appropriate for mixture experiments than the commonly used D-optimal designs, which focus on a precise model estimation rather than precise predictions. In this paper, we provide the first detailed overview of the literature on the I-optimal design of mixture experiments and identify several contradictions. For the second-order and the special cubic model, we present I-optimal continuous designs and contrast them with the published results. We also study exact I-optimal designs, and compare them in detail to continuous I-optimal designs and to D-optimal designs. One striking result of our work is that the performance of D-optimal designs in terms of the I-optimality criterion very strongly depends on which of the D-optimal designs is considered. Supplemental materials for this article are available online.
Analysis For The Value Of Friendship In One Piece Manga Volume 80-85 Written By Eiichiro Oda
Creators: name: Avriarno, Anugrah Yusuf
Publisher: name: Zenodo
Year: 2022
Subjects: Friendship value
manga
popular

description: Analysis For The Value Of Friendship In One Piece Manga Volume 80-85 Written By Eiichiro Oda
Dose Expansion Cohorts in Phase I Trials
Creators: name: Iasonos, Alexia
name: O’Quigley, John
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A rapidly increasing number of Phase I dose-finding studies, those based on the standard 3+3 design in particular, are being prolonged with the inclusion of dose expansion cohorts (DEC) to better characterize the toxicity profiles of experimental agents and to study disease-specific cohorts. These trials consist of two phases: the usual dose escalation phase that aims to establish the maximum tolerated dose (MTD), and the dose expansion phase that accrues additional patients, often with different eligibility criteria, and where additional information is collected. Currently, not all protocols specify whether and how the MTD will be updated in the light of new data accumulated from the DEC. Here, we propose methods that allow monitoring of safety in the DEC by reevaluating the MTD in light of additional information. Our working assumption is that, regardless of the design being used for dose escalation, during the DEC we are experimenting in the neighborhood of a target dose with an acceptable rate of toxicity. We refine our initial estimate of the MTD by continuing experimentation in the immediate vicinity of the initial estimate of the MTD. The auxiliary information provided by such an evaluation will include toxicity, pharmacokinetic, efficacy, and other endpoints. We consider approaches specifically focused on the aims of DEC that examine efficacy alone or simultaneously with safety. Simulations provide further insight into the behavior of the proposed tests. Supplementary materials for this article are available online.
Dose expansion cohorts in Phase I trials
Creators: name: Iasonos, Alexia
name: O’Quigley, John
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A rapidly increasing number of Phase I dose-finding studies, those based on the standard 3+3 design in particular, are being prolonged with the inclusion of dose expansion cohorts (DEC) in order to better characterize the toxicity profiles of experimental agents and to study disease-specific cohorts. These trials consist of two phases: the usual dose escalation phase that aims to establish the maximum tolerated dose (MTD), and the dose expansion phase that accrues additional patients, often with different eligibility criteria, and where additional information is collected. Currently, not all protocols specify whether and how the MTD will be updated in the light of new data accumulated from the DEC. Here, we propose methods that allow monitoring of safety in the DEC by re-evaluating the MTD in light of additional information. Our working assumption is that, regardless of the design being used for dose escalation, during the DEC we are experimenting in the neighborhood of a target dose with an acceptable rate of toxicity. We refine our initial estimate of the MTD by continuing experimentation in the immediate vicinity of the initial estimate of the MTD. The auxiliary information provided by such an evaluation will include toxicity, pharmacokinetic, efficacy and other endpoints. We consider approaches specifically focused on the aims of DEC that examine efficacy alone or simultaneously with safety. Simulations provide further insight into the behavior of the proposed tests.
Inflectional morphology in German hearing-impaired children
Creators: name: Penke, Martina
name: Wimmer, Eva
name: Hennies, Johannes
name: Hess, Markus
name: Rothweiler, Monika
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Despite modern hearing aids, children with hearing impairment often have only restricted access to spoken language input during the ‘critical’ years for language acquisition. Specifically, a sensorineural hearing impairment affects the perception of voiceless coronal consonants which realize verbal affixes in German. The aim of this study is to explore if German hearing-impaired children have problems in producing and/or acquiring inflectional suffixes expressed by such phonemes. The findings of two experiments (an elicitation task and a picture-naming task) conducted with a group of hearing-impaired monolingual German children (age 3–4 years) demonstrate that difficulties in perceiving specific phonemes relate to the avoidance of these same sounds in speech production independent of the grammatical function these phonemes have.
The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils
Creators: name: Dudzinska, Dominika
name: Bednarska, Katarzyna
name: Boncler, Magdalena
name: Boguslawa Luzak
name: Watala, Cezary
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: Recently, polyphenols have gained attention as potential natural cardioprotective therapeutics, due to their antiplatelet, anti-inflammatory and anticoagulant activity. Species belonging to the genus Rubus sp. have been reported to be a source of polyphenolic compounds with antioxidative proprieties and beneficial biological activities. This study investigates the effects of leaf extracts obtained from red raspberry (Rubus idaeus L.) and European dewberry (Rubus caesius L.) on the reactivity of blood platelets. In ADP-stimulated blood, raspberry and dewberry extracts (15 µg/ml) markedly decreased platelet surface membrane expression of activated GPIIbIIIa receptor by 16% and 21%, respectively (P < 0.01) and significantly inhibited platelet aggregation (by 31–41% for raspberry and by 38–55% for dewberry, P < 0.01). In platelet-rich plasma (PRP), the extracts had no effect on ADP-induced platelet aggregation. The effectiveness of the extracts in whole blood and the lack of their activity in PRP indicate that leukocytes are likely to participate in the platelet response to the extracts. Our experiments show that the extracts significantly reduced the amount of free radicals released by activated neutrophils in whole blood (P < 0.001), as well as in suspensions of isolated neutrophils (P < 0.05). Moreover, the reduced number of neutrophils leads to the decreased efficiency of the extracts in the inhibition of platelet aggregation. In summary, our findings show that the raspberry and dewberry leaf extracts considerably modulated blood platelet reactivity in whole blood: they influenced blood platelet aggregation, possibly via the modulation of the redox status dependent on the oxidative activity of neutrophils.
Análise Não-ETL de Estrelas do Disco Galáctico - Tese de Doutorado
Creators: name: Bragança, Gustavo
Publisher: name: figshare
Year: 2017
Subjects: subject: 20104 Galactic Astronomy
subject: FOS: Physical sciences
subject: Astrophysics

description: Neste trabalho, analisamos espectros de alta resolução de uma grande amostra de estrelas OB do disco galáctico a fim de estudar a distribuição de velocidade rotacional projetada (vseni) e a distribuição radial de abundâncias no disco externo Galáctico.
A distribuição de vseni de estrelas OB da Galáxia é bimodal.Ao separaramos as estrelas em objetos de campo, associação ou de aglomerado, notamos que a distribuição da velocidade rotacional é diferente para cada conjunto, sendo a velocidade média das estrelas de campo menor que a das estrelas de aglomerado. As possíveis explicações seriam os diferentes estados evolucionários típicos de cada conjunto estelar ou a densidade da nuvem progenitora destas estrelas. Determinamos que nossas amostra de vseni pode ser descrita por duas distribuições maxwellianas e encontramos a tendência de vseni de estrelas de aglomerado terem, em média, vseni maior que as estrelas de campo.
Há falta de consenso no gradiente radial de abundâncias químicas do disco fino Galáctico, parâmetro essencial para vincular modelos de evolução química da Galáxia. Desenvolvemos uma metodologia baseada em síntese espectral não-ETL destinada a obter os parâmetros estelares a partir dos espectros, incluindo as abundâncias de silício e oxigênio. Assim, obtivemos os parâmetros estelares e encontramos gradientes radiais de -0.065 e -0.054 dex/kpc para silício e oxigênio, respectivamente.O procedimento normal para definir um gradiente radial de abundância é através de uma única regressão linear, porém alguns autores apontam que um modelo com duas regressões lineares divididas em aproximadamente 10 kpc do centro Galáctico seria uma melhor descrição do gradiente. Não encontramos evidência que nossos dados seriam melhor descritos por um gradiente radial de duas zonas.
ALTERAÇÃO DE BASE ALAR DE PACIENTES SUBMETIDOS A OSTEOTOMIA LE FORT I ASSOCIADO A OSTEOTOMIA SUBESPINHAL E A RELAÇÃO COM O POSICIONAMENTO NASAL: REVISÃO LITERÁRIA
Creators: name: Isabella Virgílio Benício da SILVA
name: Ana Laura Dias MARINHO
name: Eduardo Eliasson Costa BEZERRA
Publisher: name: Zenodo
Year: 2024
Subjects: Le Fort I
Osteotomia Subespinhal
Base Alar
Posicionamento Nasal

description: RESUMO

Introdução: A osteotomia Le Fort I é um procedimento cirúrgico amplamente utilizado para correções maxilo faciais, permitindo o reposicionamento do maxilar superior. No entanto, essa intervenção pode levar a modificações estéticas e funcionais significativas na região nasal, particularmente na base alar. Objetivo: Realizar uma revisão de literatura com o intuito de fazer um comparativo das modificações na base alar em pacientes submetidos à osteotomia de Le Fort I associada à osteotomia sub espinhal. Métodos: A metodologia envolveu uma revisão da literatura científica disponível, com busca em bases de dados relevantes, como PubMed, Scopus, Web of Science, e Google Scholar. A busca foi realizada utilizando palavras-chave relacionadas, como "osteotomia Le Fort I", "osteotomia subespinhal", "base alar", "posicionamento nasal", entre outras, relevantes. Resultados: Com base na revisão da literatura, conclui- se que a osteotomia Le Fort I associada à osteotomia subespinhal tem impacto significativo na base alar e no posicionamento nasal dos pacientes submetidos a essa intervenção cirúrgica. Conclusão: É essencial um planejamento preciso e individualizado para otimizar os resultados estéticos e funcionais, considerando as particularidades de cada paciente e os objetivos cirúrgicos. São necessárias mais pesquisas para aprofundar nosso entendimento sobre essa combinação de procedimentos e suas implicações clínicas.
Deliverable 5.2 Results of the experiment / Case study
Creators: name: Imbert, Enrica
name: Falcone, Pasquale Marcello
name: D´Adamo, Idiano
name: Morone, Piergiuseppe
name: Ladu, Luana
name: Quitzow, Rainer
name: Wurster, Simone
name: Iersel, Sjors Van
name: Ugarte, Sergio
name: Voogt, Monique
name: Crepy, Mathilde
Publisher: name: Zenodo
Year: 2019
Subjects: Delphi survey; Field experiment; Bio-based products; sustainabilty; willinness to pay (WTP)

description: Efforts to promote a sustainable bioeconomy seek to enable markets that create value from renewable resources while satisfying sustainability requirements. Despite recent progress in several European countries in launching strategies to support a bioeconomy, market demand for bio-based products remains moderate. More analysis is required to better understand the drivers and barriers for enabling consumer demand for bio-based products, in particular as this relates to consumers’ sustainability concerns. A previous report developed within the scope of the STAR-ProBio project has presented the results of two rounds of a Delphi survey aimed at better understanding the sustainability preferences of procurement professionals and end consumers. Building on these results, the following tasks were completed: a third and final round of the Delphi survey was conducted with procurement professionals and a framed field experiment was conducted with end consumers to identify their willingness to pay a premium for different types of bio-based products with and without sustainability certification. This report presents the results from these tasks. In particular, it covers findings on the following: i) the relevance of information on final disposal and ii) preferences regarding information on the bio-based raw materials used, including questions related to the share and origin of bio-based raw materials and the form in which this information is communicated. In addition, the report discusses survey results on sustainability principles and potential policy options to promote the demand for bio-based products. The field experiment conducted on three products, i.e. coloured pens, hand soap and food storage bags shows that on average end consumers assign a higher price for bio-based products than conventional ones.
Verdadero y nuevo ejemplar en el que se da cuenta y declara la cruel muerte que le han dado a un tal Joaquín de Mata : Digital Edition
Creators: name: Jacsont Pauline
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool eScriptorium (ALTO-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Interview Transcripts as Part of the Evaluation of the Master Thesis 'Concepts and Implementation of a Wireless Sensor Network for Forest Environment Monitoring'
Creators: name: Pfister, Zoe Michaela Dietmar
Publisher: name: Zenodo
Year: 2024

description: Interview Transcripts as Part of the Evaluation of the Master Thesis 'Concepts and Implementation of a Wireless Sensor Network for Forest Environment Monitoring'
Mathematical Modelling and Control of Underactuated Mechanical Systems Using MATLAB & Simulink.
Creators: name: Parunandula, Shravankumar
Publisher: name: figshare
Year: 2016
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 91007 Manufacturing Robotics and Mechatronics (excl. Automotive Mechatronics)
subject: Applied Physics
subject: Mechanics

description: In this paper we presented how a physical systemcan be represented as a mathematical model.We used MATLAB’ssymbolic mathematics tool to solve the system dynamic equations.These systems are highly non-linear, so we linearized the systemat unstable fixed points using Taylor series expansion and optimalcontrol algorithms such as Linear Quadratic Regulator(LQR) tobalance the system at the desired position.
Entfernungen auf der Erdoberfläche
Creators: name: Schröer, Harald
Publisher: name: Zenodo
Year: 2015
Subjects: earth, ellipsoid, distance,geodesics, Entfernung

description: Es werden 3 Verfahren zur Berechnung der Entfernung auf der Erdoberfläche vorgestellt, für kurze, mittlere und große Entfernungen. Die Erde wird dabei als Rotationsellipsoid angenommen. (2.geodätische Grundaufgabe)
description: German
title: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 59 Nr. 2 (2018): Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
title: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
titleType: AlternativeTitle
Creators: name: Burgen Und Schlösser-Zeitschrift Für Burgenforschung Und Denkmalpflege
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2018

description: (vorerst nur Inhaltsverzeichnis)
description: Inhalt...65
title: Mails à Bernard Hirschel - Pièce jointe
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Pièces jointes : "Puis Vinrent les Antiviraux" ; "Diminuer les prises d'antiviraux anti VIH combinés, de 7 jours sur 7, à 5, puis 4, puis 3 jours par semaine ".
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111135137815
description: created: start=2008-11-12;end=2009-01-06
Verdadero y nuevo ejemplar en el que se da cuenta y declara la cruel muerte que le han dado a un tal Joaquín de Mata : Digital Edition
Creators: name: Jacsont Pauline
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool eScriptorium (ALTO-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
New structural and Re–Os geochronological evidence constraining the age of faulting and associated mineralization in the Devonian Orcadian Basin, Scotland
Creators: name: A.M. Dichiarante
name: R.E. Holdsworth
name: E.D. Dempsey
name: D. Selby
name: K.J.W. McCaffrey
name: U. McL. Michie
name: G. Morgan
name: J. Bonniface
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Appendix 1: Onshore and offshore fault and fracture lineament data
title: 03_0863
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Dissociable saccadic suppression of pupillary and perceptual responses to light
Creators: name: Benedetto, Alessandro
name: Binda, Paola
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience and Physiological Psychology

description: We measured pupillary constrictions in response to full-screen flashes of variable luminance, occurring either at the onset of a saccadic eye movement or well before/after it. A large fraction of peri-saccadic flashes were undetectable to the subjects, consistent with saccadic suppression of visual sensitivity. Likewise, pupillary responses to peri-saccadic flashes were strongly suppressed. However, the two phenomena appear to be dissociable. Across subjects and luminance levels of the flash stimulus, there were cases where conscious perception of the flash was completely depleted yet the pupillary response was clearly present, as well as cases where the opposite occurred. On the one hand, the fact that pupillary light responses are subject to saccadic suppression reinforces evidence that this is not a simple reflex, but depends on the integration of retinal illumination with complex 'extra-retinal' cues. On the other hand, the relative independence of pupillary and perceptual responses suggests that suppression acts separately on these systems - consistent with the idea of multiple visual pathways that are differentially affected by saccades.