Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Creators: name: Lee, Nanette R.
name: Lee, Jong Young
name: Li, Shengxu
name: Juang, Jyh Ming J.immy
name: Young, Terri L.
name: Rice, Treva K.
name: Gui, Lixuan
name: Lee, Jeannette
name: Zheng, Wei
name: Kim, Eric
name: Tabara, Yasuharu
name: Assimes, Themistocles L.
name: Nabika, Toru
name: Wu, Ying
name: Shin, Dong H.oon
name: Ong, Rick T.h.
name: Long, Jirong
name: Umemura, Satoshi
name: Gao, Yu Tang
name: Ji, Bu Tian
name: Wu, Chen
name: Liu, Jian J.un
name: Tsunoda, Tatsuhiko
name: Lee, Wen Jane
name: Yang, Xiaobo
name: Chen, Yii Der I.
name: Song, Huaidong
name: Hu, Frank
name: Lin, Xu
name: Go, Min J.in
name: Tanaka, Toshihiro
name: Lee, Young Hoon
name: Mo, Zengnan
name: Chun, Byung Yeol
name: Hixson, James
name: Gan, Wei
name: Takashima, Naoyuki
name: Cai, Qiuyin
name: Choi, Bo Y.oul
name: Lee, Juyoung
name: Shin, Min Ho
name: Adair, Linda S.
name: He, Meian
name: Aung, Tin
name: Wu, Tangchun
name: Shu, Xiao Ou
name: Kim, Mi K.yung
name: Miki, Tetsuro
name: Wong, Tien Y.in
name: Kubo, Michiaki
name: Cho, Yoon S.hin
name: Hsiung, Chao A.gnes
name: Takayanagi, Ryoichi
name: Kuo, Jane Z.
name: Yamamoto, Ken
name: Guo, Xingyi
name: Zhou, Xueya
name: Wu, I. Chien
name: Mohlke, Karen L.
name: Lee, I. Te
name: Gu, Dongfeng
name: Kim, Young J.in
name: Kim, Bong Jo
name: Tai, E. Shyong
name: Isono, Masato
name: Tan, Aihua
name: Xiang, Yong Bing
name: Wang, Tzung Dao
name: Kang, Dae Hee
name: Kato, Norihiro
name: Lim, Wei Y.en
name: Okada, Yukinori
name: Wu, Jer Yuarn
name: Taylor, Kent D.
name: Liang, Jun
name: Li, Huaixing
name: Zhang, Yi
name: Tsai, Fuu Jen
name: Lu, Wei
name: Isomura, Minoru
name: Guo, Xiuqing
name: Gao, Yong
name: Lu, Ling
name: Ohkubo, Takayoshi
name: Rotter, Jerome I.
name: Shi, Jiajun
name: Delahanty, Ryan
name: Han, Bok Ghee
name: He, Jiang
name: Qi, Lu
name: Dorajoo, Rajkumar
name: Zhu, Dingliang
name: Wen, Wanqing
name: Sheu, Wayne H.uey Herng
name: Takeuchi, Fumihiko
name: Hwu, Chii Min
name: Cho, Myeong Chan
name: Hwang, Joo Yeon
name: Chen, Ching Chu
name: Lim, Wei Yen
name: Sim, Xueling
name: Allison, Matthew
name: Akiyama, Koichi
name: Yao, Jie
name: Seielstad, Mark
name: Yan, Xiaofei
name: Kwon, Soonil
name: Absher, Devin
name: Chen, Chien Hsiun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10−13), ALDH2/MYL2 (rs671, P = 3.40 × 10−11; rs12229654, P = 4.56 × 10−9), ITIH4 (rs2535633, P = 1.77 × 10−10) and NT5C2 (rs11191580, P = 3.83 × 10−8) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10−8) and an additional 14 at P < 1.0 × 10−3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.