cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An empirical study of bureaucratic structural dimensions and their relationship to the variable organizational size.
Creators: name: Goodwin, John R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1978
Subjects: subject: Business Administration, Management.

description: Although the organizational size literature has doubled in each five year period for the last twenty years, evidence on the effect and relationship of organizational size and organizational structure has been inconsistent and inconclusive. Do differences exist in organizational structure that reflect the differences in the size of the organization? The purpose of this study was to investigate the above question through examination of a set of homogeneous organizations. The organizational units investigated are the Ontario Colleges of Applied Arts and Technology. The general theoretical framework for the study was derived from Weber's bureaucratic theory (1947), the Aston group's contextual and structural variables (1968), and Reimann's framework of structural dimensions (1973). Based on this general framework, the study examined the relationship between organizational size and dimensions of organizational structure. In particular, the research investigated (a) the measures of size, (b) the size-structural relationship, (c) organizational size as determinant of organizational structure, and (d) the dimensionality of structure. As was predicted, a significant relationship existed between size and certain structural dimensions. Size was found to be positively related to specialization, delegation, vertical span, supervisory span (subordinate ratio), and was negatively related to centralization. A marked exception to the predicted relationship was the small negative correlation between size and formalization. A secondary question answered in this study has to do with the dimensionality of the structural variables. Principal component analysis indicated that the structural variables were reduceable to four independent structural dimensions. The multidimensional concept of structure was supported. Suggestions for further research included: (1) analysing the effect of structural adaptation to size on the overall effectiveness of the organization; (2) isolation of other of the contextual variables and studying their effect on structure; (3) relating organizational size, organizational complexity, and organizational structure; (4) relating organizational size, organizational differentiation and organizational structure; (5) a longitudinal study of organizational size and organizational structure in the Ontario colleges.
Exploring FGF21's mechanism of acute insulin sensitization
Creators: name: King-McAlpin, Sheps
Publisher: name: University of Iowa
Year: 2025

description: Fibroblast growth factor 21 (FGF21) in an endocrine hormone that regulates carbohydrate homeostasis and is also a potential drug target for treating diabetes and other metabolic diseases. Circulating FGF21 is derived primarily from the liver and signals through a receptor complex consisting of β-klotho (KLB) and FGFR1c on tissues including the central nervous system and adipose tissues to mediate its metabolic effects. Acute administration of FGF21 to rodents enhances insulin sensitivity through direct actions on brown adipose tissue (BAT). However, FGF21’s insulin-sensitizing effect is variable in adult humans as it depends on the FGF21 analog used. This inconsistency between rodents and humans could be because adult humans have less BAT than mice when normalized to total respective body weights. Since BAT and skeletal muscle are derived from the same progenitor cells, we wanted to know if skeletal muscle could serve as a target tissue for FGF21-mediated enhancement of insulin-stimulated glucose uptake in humans. To explore the mechanism for FGF21’s acute insulin-sensitizing effect while examining whether this effect could be applied to skeletal muscle, a tissue which lacks the obligate FGF21 coreceptor KLB, we generated a mouse model overexpressing KLB in skeletal muscle. FGF21 did not improve insulin sensitivity through KLB-expressing skeletal muscle. To investigate FGF21’s mechanism of improving insulin sensitivity through BAT, we employed a unique GLUT4 translocation reporter system that dynamically reports insulin sensitivity in real-time. Here we show that FGF21 enhances GLUT4 translocation in BAT and brown adipocytes. Furthermore, we used global phosphoproteomics to identify signaling intermediates that are phosphorylated by FGF21 in primary brown adipocytes. These studies provide unique insight into the insulin-sensitizing effects of FGF21 and highlights specific FGF21 signaling intermediates to be characterized in pursuit of a novel therapeutic strategy for diabetes.
Milan Kundera essayiste ou l'art du paradoxe.
Creators: name: Bissonnette, Annie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Literature, Modern.

description: Le rayonnement des romans de Milan Kundera aura laissé dans l'ombre ses deux essais. Condamnés à servir de commentaire à son art du roman, on a négligé de les aborder dans leur spécificité. Cette étude propose donc une analyse esthétique de Kundera essayiste à travers le prisme de la thématique du paradoxe. Si Kundera romancier explore des possibilités existentielles dans le piège qu'est le monde, Kundera essayiste cherche à jeter un éclairage lucide sur nos mythologies modernes dans un monde envahi par le kitsch et la non-pensée des idées reçues. Avec un plaisir d'hérétique, c'est à titre de bouffon intellectuel que Kundera nous convie à cet appel au questionnement qu'est l'essai en reprenant le stratagème favori des humanistes de la Renaissance, le paradoxe. Il s'agira d'explorer les différents mécanismes, la variation, la pensée expérimentale, la carnavalisation et la redéfinition, de cette esthétique originale et scandaleusement paradoxale, qui vise à nous ébranler poétiquement .
Activity-based cost analysis of hepatic tumor ablation using CT-guided high- dose rate brachytherapy or CT-guided radiofrequency ablation in hepatocellular carcinoma
Creators: name: Schnapauff, D.
name: Collettini, F.
name: Steffen, I.
name: Wieners, G.
name: Hamm, B.
name: Gebauer, B.
name: Maurer, M. H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: CT guidance
subject: High-dose rate brachytherapy
subject: Radiofrequency ablation
subject: Cost analysis
subject: Liver
subject: Minimally invasive treatment
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Purpose To analyse and compare the costs of hepatic tumor ablation with computed tomography (CT)-guided high-dose rate brachytherapy (CT-HDRBT) and CT-guided radiofrequency ablation (CT-RFA) as two alternative minimally invasive treatment options of hepatocellular carcinoma (HCC). Materials and methods An activity based process model was created determining working steps and required staff of CT-RFA and CT-HDRBT. Prorated costs of equipment use (purchase, depreciation, and maintenance), costs of staff, and expenditure for disposables were identified in a sample of 20 patients (10 treated by CT-RFA and 10 by CT-HDRBT) and compared. A sensitivity and break even analysis was performed to analyse the dependence of costs on the number of patients treated annually with both methods. Results Costs of CT-RFA were nearly stable with mean overall costs of approximately 1909 €, 1847 €, 1816 € and 1801 € per patient when treating 25, 50, 100 or 200 patients annually, as the main factor influencing the costs of this procedure was the single-use RFA probe. Mean costs of CT-HDRBT decreased significantly per patient ablation with a rising number of patients treated annually, with prorated costs of 3442 €, 1962 €, 1222 € and 852 € when treating 25, 50, 100 or 200 patients, due to low costs of single-use disposables compared to high annual fix-costs which proportionally decreased per patient with a higher number of patients treated annually. A break-even between both methods was reached when treating at least 55 patients annually. Conclusion Although CT-HDRBT is a more complex procedure with more staff involved, it can be performed at lower costs per patient from the perspective of the medical provider when treating more than 55 patients compared to CT-RFA, mainly due to lower costs for disposables and a decreasing percentage of fixed costs with an increasing number of treatments.
An x-ray study of the effects of stellar feedback on galaxy evolution and structure
Creators: name: Bluem, Jesse
Publisher: name: University of Iowa
Year: 2022
Subjects: Circumgalactic Medium
Compact Objects
Feedback
Galaxies
Supernovae
X-rays
public abstract
Physics

description: Stars and star formation regions within a galaxy can have a significant effect on the properties of that galaxy. The engine driving these changes is feedback produced by the birth, life, and death of these stars. Feedback describes the effect of energy and momentum being ejected from a source back into the greater galaxy. Evidence of these feedback sources and the changes they cause can be detected in X-ray observations of galaxies. In this thesis we examine these effects in a fewways. First, we look at X-ray observations of the circumgalactic medium (CGM), the hot gas and plasma surrounding the disk of our Galaxy. The CGM is found to have a patchy distribution, reflecting contributions from feedback processes in the disk. Second, we analyze the Cygnus Superbubble (CSB), a large X-ray structure in the Galactic disk. Due to consistent properties across the structure, the CSB is found to likely be a cohesive structure, potentially a hypernova remnant. This would make it the only known example of a hypernova remnant in our Galaxy, and a significant feedback source. Finally we look at X-ray sources in a set of 8 low-metallicity galaxies, finding X-ray sources in 5 of these galaxies, 4 of which are notably luminous. These sources are all likely to be X-ray binaries, potentially powerful feedback engines. Evidence is found that the galaxies with these X-ray sources are depleted in dust, potentially because of feedback from the X-ray sources.
Elderly women's narratives of falling, fear of falling, the role of physical activity and their impact on autonomy and quality of life.
Creators: name: Davis, Nancy M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Gerontology.

description: The focus of this thesis was on aging women residing in a nursing home and their lived experiences in relation to falls. The study examined the issue of falling and its impact on the women's autonomy and quality of life. In addition, the issue of physical activity experienced in their younger years and currently, was explored in relation to falling and fear of falling. A qualitative methodology was used and individual interviews were conducted among 10 elderly women (79 to 95 years old) residing in a nursing home in the Ottawa region. Most of the women entered the nursing home for reasons of solitude, or not wanting to burden their children with their care, or because of injuries sustained from a fall. The results showed that the majority of the women were forced to change many of their previous life patterns as a result of a fall and its consequences. Their falls all resulted in injuries, often traumatic experiences, and left most of the women with feelings of helplessness, annoyance and frustration. Fear of falling again was a feeling shared by most of the women in this study and this fear made them careful with their movements in the nursing home. As a result, they relied quite heavily on the use of assistive devices for mobility within their environment. Most of the women did not pursue many physical activities for pleasure purposes when they were younger. Their activity came from working around the home and the farm as well as walking to destinations. Within the nursing home environment, the majority of the women did not participate in the physical activity programs offered and found it difficult to imagine what could draw them into physical activity, given their advanced age and fear of falling again.
Constant volume ring shear test for sand.
Creators: name: Infante Sedano, Julio Angel.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Engineering, Civil.

description: A ring shear device was designed to permit constant volume tests to be performed on granular materials. Constant volume ring shear tests can be used to simulate undrained conditions of shearing. The very large deformations allowed by the ring shear device are well suited to determine the steady-state strength of granular material. The steady state strength is an important parameter in evaluating the stability of sand deposits against flow sliding. The main contributions of this study are as follows: (1) Tools and methods were developed to prepare annular samples of granular materials. (2) Tools and methods were developed to verify the quality of the samples prepared. (3) Tests on Unimin 2010 quartz sand showed that for this material, the steady state shear strength is independent of the presence of water, the rate of shear, and the fines content. (4) There is good agreement in the steady state line obtained from constant load and constant volume ring shear tests with that obtained from triaxial tests. (5) The constant volume ring shear test provides a lower steady-state friction angle than the undrained triaxial test.
Linking unfounded beliefs to genetic dopamine availability
Creators: name: Schmack, Katharina
name: Rössler, Hannes
name: Sekutowicz, Maria
name: Brandl, Eva J.
name: Müller, Daniel J.
name: Petrovic, Predrag
name: Sterzer, Philipp
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: dopamine
subject: COMT
subject: haplotype
subject: visual perception
subject: beliefs
subject: 500 Naturwissenschaften und Mathematik::540 Chemie

description: Unfounded convictions involving beliefs in the paranormal, grandiosity ideas or suspicious thoughts are endorsed at varying degrees among the general population. Here, we investigated the neurobiopsychological basis of the observed inter-individual variability in the propensity toward unfounded beliefs. One hundred two healthy individuals were genotyped for four polymorphisms in the COMT gene (rs6269, rs4633, rs4818, and rs4680, also known as val158met) that define common functional haplotypes with substantial impact on synaptic dopamine degradation, completed a questionnaire measuring unfounded beliefs, and took part in a behavioral experiment assessing perceptual inference. We found that greater dopamine availability was associated with a stronger propensity toward unfounded beliefs, and that this effect was statistically mediated by an enhanced influence of expectations on perceptual inference. Our results indicate that genetic differences in dopaminergic neurotransmission account for inter-individual differences in perceptual inference linked to the formation and maintenance of unfounded beliefs. Thus, dopamine might be critically involved in the processes underlying one's interpretation of the relationship between the self and the world.
Biased Recognition of Facial Affect in Patients with Major Depressive Disorder Reflects Clinical State
Creators: name: Münkler, Paula
name: Rothkirch, Marcus
name: Dalati, Yasmin
name: Schmack, Katharina
name: Sterzer, Philipp
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Cognitive theories of depression posit that perception is negatively biased in depressive disorder. Previous studies have provided empirical evidence for this notion, but left open the question whether the negative perceptual bias reflects a stable trait or the current depressive state. Here we investigated the stability of negatively biased perception over time. Emotion perception was examined in patients with major depressive disorder (MDD) and healthy control participants in two experiments. In the first experiment subjective biases in the recognition of facial emotional expressions were assessed. Participants were presented with faces that were morphed between sad and neutral and happy expressions and had to decide whether the face was sad or happy. The second experiment assessed automatic emotion processing by measuring the potency of emotional faces to gain access to awareness using interocular suppression. A follow-up investigation using the same tests was performed three months later. In the emotion recognition task, patients with major depression showed a shift in the criterion for the differentiation between sad and happy faces: In comparison to healthy controls, patients with MDD required a greater intensity of the happy expression to recognize a face as happy. After three months, this negative perceptual bias was reduced in comparison to the control group. The reduction in negative perceptual bias correlated with the reduction of depressive symptoms. In contrast to previous work, we found no evidence for preferential access to awareness of sad vs. happy faces. Taken together, our results indicate that MDD-related perceptual biases in emotion recognition reflect the current clinical state rather than a stable depressive trait.
Down-Regulation of Metallothionein 1 and 2 after Exposure to Electromagnetic Field in Mouse Testis
Creators: name: Ebrahimi-Kalan, Abbas
name: Mehryar Habibi Roudkenar
name: Raheleh Halabian
name: Peiman Broki Milan
name: Zarrintan, Armin
name: Amaneh Mohammadi Roushandeh
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Potency of Full- Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations
Creators: name: Janssen, Joseph A. M. J. L.
name: Hofland, Leo J.
name: Strasburger, Christian J.
name: Dungen, Elisabeth S. R. Van Den
name: Thevis, Mario
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Aims To compare full-length mechano growth factor (full-length MGF) with human recombinant insulin-like growth factor-I (IGF-I) and human recombinant insulin (HI) in their ability to activate the human IGF-I receptor (IGF-IR), the human insulin receptor (IR-A) and the human insulin receptor-B (IR-B), respectively. In addition, we tested the stimulatory activity of human MGF and its stabilized analog Goldspink-MGF on the IGF-IR. Methods The effects of full- length MGF, IGF-I, human mechano growth factor (MGF), Goldspink-MGF and HI were compared using kinase specific receptor activation (KIRA) bioassays specific for IGF-I, IR-A or IR-B, respectively. These assays quantify activity by measuring auto-phosphorylation of the receptor upon ligand binding. Results IGF-IR: At high equimolar concentrations maximal IGF-IR stimulating effects generated by full-length MGF were similar to that of IGF-I (89-fold vs. 77-fold, respectively). However, EC50 values of IGF-I and full-length MGF for the IGF-I receptor were 0.86 nmol/L (95% CI 0.69–1.07) and 7.83 nmol/L (95% CI: 4.87–12.58), respectively. No IGF-IR activation was observed by human MGF and Goldspink-MGF, respectively. IR-A/IR-B: At high equimolar concentrations similar maximal IR-A stimulating effects were observed for full -length MGF and HI, but maximal IR-B stimulation achieved by full -length MGF was stronger than that by HI (292-fold vs. 98-fold). EC50 values of HI and full-length MGF for the IR-A were 1.13 nmol/L (95% CI 0.69–1.84) and 73.11 nmol/L (42.87–124.69), respectively; for IR-B these values were 1.28 nmol/L (95% CI 0.64–2.57) and 35.10 nmol/L (95% 17.52–70.33), respectively. Conclusions Full- length MGF directly stimulates the IGF-IR. Despite a higher EC50 concentration, at high equimolar concentrations full-length MGF showed a similar maximal potency to activate the IGF-IR as compared to IGF-I. Further research is needed to understand the actions of full-length MGF in vivo and to define the physiological relevance of our in vitro findings.
The stochastic analysis of technical redundant systems.
Creators: name: Subramanian, Parmeshwar.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Engineering, Mechanical.

description: Today computers are widely used and their failures can lead to catastrophe. Redundancy is used to improve computer system reliability. This study presents a qualitative analysis of triple modular redundant (TMR) systems with redundant voters that can help to reduce the risk of failures. The voters examine the output of triple modular systems. Markov technique was employed to perform the analysis. Generalized formulas for reliability and mean time to failures of TMR systems with N voters have been developed. In addition, the system state probabilities in s-domain and steady state probabilities have been presented. The study clearly demonstrates improvements in system reliability, mean time to failure and steady state availability by the introduction of repair and redundancy in these systems.
The consequences of regulation of hepatocyte identity by the unfolded protein response (UPR) during ER stress in the liver
Creators: name: Shah, Anit
Publisher: name: University of Iowa
Year: 2023
Subjects: De-differentiation
ER Stress
Hnf4a (Hepatocyte Nuclear Factor 4a)
Liver
Primary Hepatocytes/Hepatocytes
Unfolded Protein Response (UPR)
public abstract

description: Endoplasmic reticulum (ER) stress is implicated in the etiologies of several chronic liver diseases. Upon ER stress, the unfolded protein response (UPR) is activated, and regulates transcription to maintain ER homeostasis, but the consequences of UPR activation for liver function are not well understood. Previous in-silico analysis from our and other groups has suggested that the UPR interferes with the gene regulatory network that maintains hepatocyte identity, possibly by interfering with hepatocyte nuclear factor 4α (Hnf4α/Hnf4a), a liver enriched transcription factor and a master regulator of hepatocyte differentiation. Yet it is unclear why the UPR, which has evolved to protect ER function principally by upregulating ER chaperones, would also suppress hepatocyte identity. We hypothesized that the purpose of UPR-mediated de-differentiation of hepatocytes is to protect against ER stress. We used parallel in vivo and in vitro approaches to test this hypothesis. In vivo, we challenged Hnf4a liver-specific knockout animals with the ER stress-inducing agent tunicamycin (TM). RNA-seq analysis indicated that a large majority of genes suppressed by ER stress were Hnf4 targets, showing that ER stress partially phenocopies hepatocyte loss of Hnf4a. Interestingly, gene set enrichment analysis showed a broad attenuation of UPR activation upon TM challenge in Hnf4a LKO animals, suggesting they resist ER stress. Supporting this idea, ER ultrastructure was less disrupted by TM in Hnf4aLKO animals than in wild-type littermates. These results suggested that loss of Hnf4α, which causes hepatocyte dedifferentiation, protects the ER from stress. In vitro, we tested the hypothesis that de-differentiation is protective against ER stress by exploiting the natural tendency of primary hepatocytes to dedifferentiate, comparing ER stress responsiveness in cells allowed to dedifferentiate or pharmacologically maintained in a five-chemical (5C) cocktail of differentiation-maintaining small molecules. Mirroring our results in vivo, dedifferentiated primary hepatocytes showed diminished UPR activation in response to ER stress compared to differentiated hepatocytes. Surprisingly, this result could not be explained by a diminished load of nascent ER client proteins in dedifferentiated cells, nor by altered ER chaperone expression. Rather, dedifferentiated cells showed attenuated metabolic production of NADPH, which we have shown previously to influence ER redox and stress sensitivity. Together, these data suggest that the UPR elicits hepatocyte de-differentiation as a protective mechanism for protecting against ER stress. They raise the possibility that the UPR compromises the organ's function (the liver) function in its attempt to protect the organelle (the ER).
Ninth Annual Stony Brook Music Festival Program, 1963
Creators: name: Stony Brook Community Fund
Publisher: name: Unknown
Year: 1963
Subjects: Stony Brook
Concert halls
Concerts
Amphitheaters
Programs
Music festivals

description: This is the Ninth Annual Stony Brook Music Festival Program held at the Dogwood Hollow Amphitheatre on Saturdays from July 6 through August 10, 1963. Artists featured in this program are Jose Greco, Jan Peerce, Hugo Winterhalter and Orchestra, Ferrante Teicher Pianists, Richard Rodgers, and Lionel Hampton.
Connaissances et attitudes d’infirmières ontariennes de milieu de soins tertiaires lors d’une formation sur la vaccination infantile : une étude descriptive comparative
Creators: name: Kimaz, Céline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Vaccination
Croyances
Attitudes
Connaissances

description: Mise en contexte : La vaccination est l’une des interventions de santé publique les plus efficaces. Malgré son progrès notable, l’OMS affirme que 16000 enfants de moins de 5 ans meurent encore chaque jour. Les connaissances, croyances et attitudes des parents face à la vaccination peuvent être influencées par les connaissances et attitudes des professionnels de la santé. L’impact de l’éducation des professionnels, même si elle consiste en une session unique, a un effet notable dans le domaine de la santé des familles. Des infirmières en milieu de soins tertiaires et qui sont en contact avec les familles doivent être bien informées afin de guider les parents dans leurs décisions face à la vaccination de leur enfant. Méthodologie : Une analyse des croyances des infirmières sur la vaccination infantile a précédé une étude descriptive comparative avec devis pré et post-test afin de mesurer les connaissances et attitudes des infirmières sur la vaccination infantile avant et après une courte session éducative par PowerPoint. Le modèle d’apprentissage de Gagné a été utilisé pour bâtir le plan d’enseignement de cette session d’éducation. Des analyses de type descriptif et inférentiel ont été utilisées afin de comparer ces variables chez des infirmières de pédiatrie et de chirurgie générale. Résultats : Les analyses ont démontré une augmentation significative des connaissances des infirmières suite à la session éducative ainsi qu’un changement minime de leurs attitudes. Il n’y avait pas de différence significative entre les infirmières de pédiatrie et de chirurgie. Conclusion : Cette étude a démontré l’importance d’une formation continue en milieu tertiaire concernant la vaccination infantile. Des implications et recommandations pour l’éducation, la pratique et la recherche ont été formulées afin de promouvoir des pratiques de soins adaptées aux besoins de santé des familles.
title: In-group versus out-group
title: an investigation of the potential for gendered racial subgrouping on group therapy attendance and treatment completion
titleType: Subtitle
Creators: name: Grimes, Jeffrey L.
Publisher: name: University of Iowa
Year: 2023
Subjects: Group Attendance
Group Dropout
Identity Faultlines
Subgrouping
public abstract

description: Treatment adherence, specifically attendance, is an important factor for clients to benefit from group-based treatments. Yet, little attention has been paid to understanding antecedents, particularly cultural factors, that may significantly impact clients’ attendance in group therapy. It is important for members attending group therapy sessions to benefit from these services and there is a need to understand cultural antecedents of group member attendance. This study seeks to examine the impact of cultural subgrouping vis-à-vis identity-based faultlines based on member gender and REM status on group members’ attendance rates and treatment completion. Data for this study consisted of 358 clients of 61 interpersonal process therapy groups. Identity-based faultlines were created based on members’ reported gender and race. Results indicated a significant and negative relationship between gendered racial faultlines and member attendance rates, such that members of groups with a higher likelihood to subgroup based on member race and gender attended less group therapy sessions. Regarding treatment completion, group member race and gender significantly moderated the relationship between gendered racial faultlines and treatment completion, such that the impact of gendered racial faultlines on the odds of a group member completing treatment was stronger for women compared to men, and REM members compared to White members. Findings are discussed with attention to implications and recommendations for group therapy practice and training.
Cell cycle aspects of the Unp ubiquitin protease.
Creators: name: Tibbo, Emma.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Molecular.

description: The product of the proto-oncogene Unp (ubiquitous nuclear protein) was shown to be localized in the nuclear fraction of COS-1 cell lysates. In situ studies using indirect immunofluorescence indicated that, when overexpressed in COS-1 cells, the Unp polypeptide localized in a perinuclear fashion. Minimal association with the microtubular structures of the cell was deduced, however neither the mechanism involved or the extent of their association have been determined. It has also been shown that the Unp protein follows a pattern of distribution, during the various phases of the cell cycle, similar to that exhibited by cyclin B1. During interphase both proteins appear perinuclear, however as the cell approaches mitosis they become 'diffuse' in their distribution. COS-1 cells expressing the Unp polypeptide displayed aberrant condensation of the chromosomes, whereas cells which did not express Unp exhibited the normal condensation pattern. Amino acid analysis of $\sp{32}$Phosphorus labeled Unp polypeptide demonstrated that it was phosphorylated on a serine residue.
Trans-differentiation of the Adipose Tissue-Derived Stem Cells into Neuron-Like Cells Expressing Neurotrophins by Selegiline
Creators: name: Alireza Abdanipour
name: Taki Tiraihi
name: Delshad, AliReza
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Morphometrical Study of Polysialylated Neural Cell Adhesion Molecule Positive Cells in Rat Pups Hippocampus Following Induction of Seizure during Pregnancy
Creators: name: Rajabzadeh, Ali Akbar
name: Bideskan, Ali Reza Ebrahimzadeh
name: Haghir, Hossein
name: Fazel, Ali Reza
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Single and multiple processor performance of a family of stepsize adjustment procedures for ODE solvers.
Creators: name: Yang, Ming.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, System Science.

description: The efficiency with which the numerical solution of ordinary differential equations (ODE) can be generated depends to a large extent on the effectiveness of the stepsize adjustment strategy that is used. In this thesis the relative performance of a family of stepsize adjustment strategies is examined. Included in this family is a new strategy. A distinctive feature of its formulation is the incorporation of a mechanism to correct for any persistent deviation of a prescribed solution quality measure from its desired value. The evaluation of the various strategies is undertaken through an extensive set of numerical experiments which use both single processor and multiple processor ODE solution procedures.
A short artificial antimicrobial peptide shows potential to prevent or treat bone infections
Creators: name: Bormann, N.
name: Koliszak, A.
name: Kasper, S.
name: Schoen, L.
name: Hilpert, K.
name: Volkmer, R.
name: Kikhney, J.
name: Wildemann, B.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Antimicrobials
subject: Preclinical research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Infection of bone is a severe complication due to the variety of bacteria causing it, their resistance against classical antibiotics, the formation of a biofilm and the difficulty to eradicate it. Antimicrobial peptides (AMPs) are naturally occurring peptides and promising candidates for treatment of joint infections. This study aimed to analyze the effect of short artificial peptides derived from an optimized library regarding (1) antimicrobial effect on different bacterial species, (2) efficacy on biofilms, and (3) effect on osteoblast‑like cells. Culturing the AMP-modifications with Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus (including clinical isolates of MRSA and MSSA) and Staphylococcus epidermidis identified one candidate that was most effective against all bacteria. This AMP was also able to reduce biofilm as demonstrated by FISH and microcalorimetry. Osteoblast viability and differentiation were not negatively affected by the AMP. A cation concentration comparable to that physiologically occurring in blood had almost no negative effect on AMP activity and even with 10% serum bacterial growth was inhibited. Bacteria internalized into osteoblasts were reduced by the AMP. Taken together the results demonstrate a high antimicrobial activity of the AMP even against bacteria incorporated in a biofilm or internalized into cells without harming human osteoblasts.
Insights into the evolution of parasite resistance and susceptibility in New Zealand snails
Creators: name: Higgins, Chelsea
Publisher: name: University of Iowa
Year: 2025
Subjects: subject: Gastropods
subject: Host-Parasite
subject: Negative Frequency-Dependent Selection
subject: Parasite Resistance
subject: Red Queen Hypothesis
subject: Evolution
subject: Immunology
subject: FOS: Clinical medicine

description: Host-parasite interactions are a primary source of natural selection and drive rapid evolution in natural populations. In the Potamopyrgus antipodarum-Atriophallophorus winterbourni system, the trematode parasite A. winterbourni imposes strong negative frequency-dependent selection on P. antipodarum, a New Zealand freshwater snail. This selection is associated with the maintenance of genetic diversity and sexual reproduction in the snails. While these trematodes coevolve with P. antipodarum populations, the genomic regions that drive this coevolution are still uncharacterized, leaving open fundamental evolutionary and genetic questions about the mechanisms involved.
description: I have used our newly completed P. antipodarum reference genome assembly and RNA-seq data from infected and uninfected snails from three New Zealand lakes to identify strong population-specific patterns of gene expression. Through this analysis, I have characterized a set of genes that may play a role in the coevolved response to parasitism. I also provide evidence of more rapid selection in these immune genes relative to a set of highly conserved orthologues in three Potamopyrgus species, consistent with expectations under strong negative frequency-dependent selection. This study provides new insights into the immune response of snails and the genomic basis of coevolution and highlights promising candidates for targeted research into the genetic factors driving host-parasite coevolution in freshwater snails.
3654611.pdf
Creators: name: Lu, Hsuan-Hao
name: Lukens, Joseph
name: Peters, Nicholas
name: Williams, Brian
name: Weiner, Andrew
name: Lougovski, Pavel
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: We provide details on the experimental setup, theoretical predictions, and calculations of the visibility, entanglement witness, and density matrix.
Predictors of behavioural risk factors modification in patients recovering from acute coronary heart disease.
Creators: name: Lee, Alison Claire.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Health Sciences, Public Health.

description: This present investigation is a prospective study of 123 cardiac patients who attended a community-based program of education and support, following hospital admission for acute cardiovascular disease. The objective of the study was to derive a predictive model that would maximally discriminate between participants who were vs. participants who were not successful in modifying a health-risk behaviour. The four behaviours examined were following a low-fat diet, performing regular exercise, weight reduction and smoking cessation. Readiness for change was assessed prior to the commencement of the eight-week program, at post-treatment and at five-month follow-up. Participants were grouped into two outcome groups based on their stage of change as delineated by the Transtheoretical Model. Subjects who were in the action or maintenance stages of change at seven-month follow-up were classified as Progressors, and those who were in pre-action stages were classified as Non-progressors. The variables included in the predictive model were optimism, psychological distress, social intimacy and self-efficacy. Neuroticism was also included to explore its relationship with optimism. Discriminant function analysis showed that the variables that maximally separated individuals who were successful in risk-factor modification from those who were unsuccessful were social intimacy and self-efficacy. A secondary objective of this study was to compare Progressing subjects with Non-progressing subjects on psychological distress and on two Transtheoretical Model measures, decisional balance and the processes of change. Repeated measures analysis of variance indicated a slight reduction over time in scores on the measure of psychological distress for all participants as a group. However, no differences were found in psychological distress between participants who changed their health-risk behaviour and those who did not. Because more subjects than anticipated were successful in changing their target health-risk behaviour, there were insufficient data to further compare successful changers with unsuccessful changers. Thus the data did not provide for a robust test of how individuals progress through the Transtheoretical model stages of change following a coronary event. Overall this thesis emphasizes the importance of the social context of behaviour change as evidenced by the contribution of the measure of social intimacy. In addition, this thesis offers some information on the relationship between personality constructs (e.g., neuroticism) and behaviour change, although this requires further investigation.
Estradiol regulation of the neurohypophysial hormones in the goldfish, Carassius auratus.
Creators: name: Ayoub, Fadi.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Neuroscience.

description: The neurohypophysial hormones (NHs) consist of a superfamily of nonapeptide hormones that are structurally conserved throughout vertebrates. These hormones are synthesized in neurons of the hypothalamus that project to the posterior lobe of the pituitary where they are stored and released. Most species possess two members of the superfamily that are homologous to the mammalian, arginine vasopressin (AVP) and oxytocin (OXT). In teleosts, arginine vasotocin (AVT) and isotocin (IST) replace AVP and OXT, respectively. In mammals, the NHs have distinct functions as AVP is involved with fluid homeostasis and blood pressure regulation whereas OXT is involved with reproductive physiology. In teleosts, AVT plays a role in blood pressure regulation and both AVT and IST possess some overlapping actions in the induction of spawning or parturition in various fishes. Because of these functions in teleostean reproduction, the regulation of NH gene expression by estradiol was examined in the goldfish, Carassius auratus. (Abstract shortened by UMI.)
Targeting myocyte gangliosides for cardioprotection
Creators: name: Baccam, Gabriel Christina
Publisher: name: University of Iowa
Year: 2023
Subjects: Cardioprotection
Chronic Kidney Disease
Glucosylceramide Synthase Inhibitor
Klotho
Lipid Rafts
public abstract
Heart Failure

description: A large population of patients with chronic kidney disease (CKD) develops cardiac hypertrophy, which can lead to heart failure and sudden cardiac death. Soluble klotho (sKL), the shed ectodomain of the transmembrane protein klotho, which is predominately expressed in the kidney, protects the heart against hypertrophic growth. Our lab has previously shown that sKL protects the heart by regulating the formation and function of lipid rafts by targeting the sialic acid moiety of gangliosides, specifically GM1/GM3. Reduction in circulating sKL contributes to an increased risk of cardiac hypertrophy in CKD patients. sKL replacement therapy has been highly considered. However, this method is limited by the challenges of delivering a large protein molecule such as sKL in vivo and the inability to mass-produce the protein for treatment.
description: This thesis focuses on how targeting gangliosides to regulate lipid raft formation is cardioprotective and that gangliosides are important therapeutic targets. Glycosylation of ceramide catalyzed by glucosylceramide synthase is the entry step for the formation of gangliosides. Here, we demonstrate that oral administration of a glucosylceramide synthase inhibitor (GCSi) reduces plasma and heart tissue glycosphingolipids, including gangliosides. Administration of the GCSi protects against two mouse models of stress-induced cardiac dysfunction, one with isoproterenol (ISO) overstimulation and the other with 5/6 nephrectomy-induced CKD. Treatment with GCSi does not alter the severity of renal dysfunction and hypertension in CKD. These results provide a proof of principle for targeting glucosylceramide synthase to decrease gangliosides as a suitable treatment for cardiac hypertrophy. Lastly, this thesis provides insight into alternative methods of targeting gangliosides for cardioprotection. This body of work further supports the hypothesis that sKL protects the heart by regulating the formation and function of lipid rafts by targeting gangliosides.
3654611.pdf
Creators: name: Lu, Hsuan-Hao
name: Lukens, Joseph
name: Peters, Nicholas
name: Williams, Brian
name: Weiner, Andrew
name: Lougovski, Pavel
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: We provide details on the experimental setup, theoretical predictions, and calculations of the visibility, entanglement witness, and density matrix.
3656476.pdf
Creators: name: Villanueva-Perez, Pablo
name: Pedrini, Bill
name: Mokso, Rajmund
name: Vagovic, Patrik
name: Guzenko, Vitaliy
name: Leake, Steven
name: Willmott, Philip
name: Oberta, Peter
name: David, Christian
name: Chapman, Henry
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary text
title: Severe malaria in Europe
title: an 8-year multi-centre observational study
titleType: Subtitle
Creators: name: Kurth, Florian
name: Develoux, Michel
name: Mechain, Matthieu
name: Malvy, Denis
name: Clerinx, Jan
name: Antinori, Spinello
name: Gjorup, Ida E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Malaria
subject: Falciparum
subject: Severe malaria
subject: Artesunate
subject: Quinine
subject: Plasmodium
subject: Europe
subject: Clinical study
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Malaria remains one of the most serious infections for travellers to tropical countries. Due to the lack of harmonized guidelines a large variety of treatment regimens is used in Europe to treat severe malaria. Methods The European Network for Tropical Medicine and Travel Health (TropNet) conducted an 8-year, multicentre, observational study to analyse epidemiology, treatment practices and outcomes of severe malaria in its member sites across Europe. Physicians at participating TropNet centres were asked to report pseudonymized retrospective data from all patients treated at their centre for microscopically confirmed severe Plasmodium falciparum malaria according to the 2006 WHO criteria. Results From 2006 to 2014 a total of 185 patients with severe malaria treated in 12 European countries were included. Three patients died, resulting in a 28-day survival rate of 98.4%. The majority of infections were acquired in West Africa (109/185, 59%). The proportion of patients treated with intravenous artesunate increased from 27% in 2006 to 60% in 2013. Altogether, 56 different combinations of intravenous and oral drugs were used across 28 study centres. The risk of acute renal failure (36 vs 17% p = 0.04) or cerebral malaria (54 vs 20%, p = 0.001) was significantly higher in patients ≥60 years than in younger patients. Respiratory distress with the need for mechanical ventilation was significantly associated with the risk of death in the study population (13 vs 0%, p = 0.001). Post-artemisinin delayed haemolysis was reported in 19/70 (27%) patients treated with intravenous artesunate. Conclusion The majority of patients with severe malaria in this study were tourists or migrants acquiring the infection in West Africa. Intravenous artesunate is increasingly used for treatment of severe malaria in many European treatment centres and can be given safely to European patients with severe malaria. Patients treated with intravenous artesunate should be followed up to detect and manage late haemolytic events.
Être ou ne plus être : auxiliary alternation in Ottawa-Hull French.
Creators: name: Willis, Lauren A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Language, Linguistics.

description: Contemporary grammars now admit that for many " être verbs", avoir is used as well, variously attributing the alternation to semantic, syntactic and/or stylistic distinctions. Sankoff and Thibault (1980, 1997), Canale et al. (1978) and Russo and Roberts (1999) confirm that variable avoir usage in Montreal, Welland and Sudbury and Vermont French respectively, is conditioned by such factors. In this thesis I extend the analysis of avoir / être variation to another variety of North-American French. From the speech of 45 informants selected from the Ottawa-Hull French Corpus (Poplack, 1989), I extracted every token of every verb admitting auxiliary variation, distributed across 21 verbs. Each of these was coded for a number of linguistic and non-linguistic factors hypothesized to affect variability in auxiliary choice. Some replicate those used in the earlier studies. Others are operationalizations of factors suggested to favour avoir use over the course of the development of the French language including type of complement if any, and whether the verb was also used reflexively. (Abstract shortened by UMI.)
3656476.pdf
Creators: name: Villanueva-Perez, Pablo
name: Pedrini, Bill
name: Mokso, Rajmund
name: Vagovic, Patrik
name: Guzenko, Vitaliy
name: Leake, Steven
name: Willmott, Philip
name: Oberta, Peter
name: David, Christian
name: Chapman, Henry
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplementary text