cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years
Creators: name: Unwin, David
name: Khalid, Ali Ahsan
name: Unwin, Jen
name: Crocombe, Dominic
name: Delon, Christine
name: Martyn, Kathy
name: Golubic, Rajna
name: Ray, Sumantra
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
diabetes mellitus
dietary patterns
weight management
blood pressure lowering
lipid lowering

description: Background: In a single general practice (GP) surgery in England, there was an eightfold increase in the prevalence of type 2 diabetes (T2D) in three decades with 57 cases and 472 cases recorded in 1987 and 2018, respectively. This mirrors the growing burden of T2D on the health of populations round the world along with healthcare funding and provision more broadly. Emerging evidence suggests beneficial effects of carbohydrate-restricted diets on glycaemic control in T2D, but its impact in a ‘real-world’ primary care setting has not been fully evaluated. Methods: Advice on a lower carbohydrate diet was offered routinely to patients with newly diagnosed and pre-existing T2D or prediabetes between 2013 and 2019, in the Norwood GP practice with 9800 patients. Conventional ‘one-to-one’ GP consultations were used, supplemented by group consultations, to help patients better understand the glycaemic consequences of their dietary choices with a particular focus on sugar, carbohydrates and foods with a higher Glycaemic Index. Those interested were computer coded for ongoing audit to compare ‘baseline’ with ‘latest follow-up’ for relevant parameters. Results: By 2019, 128 (27%) of the practice population with T2D and 71 people with prediabetes had opted to follow a lower carbohydrate diet for a mean duration of 23 months. For patients with T2D, the median (IQR) weight dropped from of 99.7 (86.2, 109.3) kg to 91.4 (79, 101.1) kg, p<0.001, while the median (IQR) HbA1c dropped from 65.5 (55, 82) mmol/mol to 48 (43, 55) mmol/mol, p<0.001. For patients with prediabetes, the median (IQR) HbA1c dropped from 44 (43, 45) mmol/mol to 39 (38, 41) mmol/mol, p<0.001. Drug-free T2D remission occurred in 46% of participants. In patients with prediabetes, 93% attained a normal HbA1c. Since 2015, there has been a relative reduction in practice prescribing of drugs for diabetes leading to a T2D prescribing budget £50 885 per year less than average for the area. Conclusions: This approach to lower carbohydrate dietary advice for patients with T2D and prediabetes was incorporated successfully into routine primary care over 6 years. There were statistically significant improvements in both groups for weight, HbA1c, lipid profiles and blood pressure as well as significant drug budget savings. These results suggest a need for more empirical research on the effects of lower carbohydrate diet and long-term glycaemic control while recording collateral impacts to other metabolic health outcomes.
A Ternary Algebra with Applications to Binary Quadratic Forms
Creators: name: Goins, Edray Herber
Publisher: name: arXiv
Year: 2009
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11E25; 20N10

description: We discuss multiplicative properties of the binary quadratic form $a x^2 + b x y + c y^2$ by considering a ring of matrices which is closed under a triple product. We prove that the ring forms a ternary algebra in the sense of Hestenes, and then derive both multiplicative formulas for a large class of binary quadratic forms and a type of multiplication for points on a conic section which generalizes the algebra of rational points on the unit circle.
description: Published as part of the proceedings for the Council for African American Researchers in the Mathematical Sciences (CAARMS)
title: Advances in reconstructing paleo-CO2 and ecosystem-climate-CO2 feedbacks through time
Creators: name: Moñtanez, Isabel
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Paleo-CO2 reconstructions are integral to understanding the evolution of Earth system processes and their interactions given that atmospheric CO2 concentrations are intrinsically linked to planetary function. Furthermore, past periods of major climate change provide unique insights into the response of land-atmosphere-ocean interactions to warming induced climate change, in particular for times of pCO2 comparable to those projected for our future. How well the past can inform the future, however, depends on how well paleo-CO2 estimates are constrained. In this talk, I will first discuss approaches to reconstructing paleo-CO2 concentrations, the challenges of constraining the uncertainty of these estimates, and the implications for constraining critical issues such as climate sensitivity. I will introduce a new community initiative, CO2PIP, focused on advancing the reconstruction of paleo-CO2 through modernizing of existing records and quantifying the representation of CO2 proxy sensitivities to environmental and ecophysiological conditions and processes that govern the CO2 signals. I will then focus on a deep-time glaciated period (the late Paleozoic Ice Age), characterized by pCO2 fluctuations within the range of Quaternary levels to those projected by socio-economic emission scenarios of this century, as well as defined by CO2-driven abrupt warmings that led to major changes in environmental conditions in the oceans and on land. An integrated multi-proxy data-modeling approach to investigating this deep-time icehouse provides a framework to evaluate the mechanistic linkages between processes and to conceptualize the collective data set. It further reveals the underlying processes linking pCO2 and environmental changes and documents the sensitivity of Earth System modeled atmospheric and oceanic circulation to changing pCO2. Application of paleo-CO2 and fossil plant morphologic and biogeochemical data to process-based ecosystem modeling documents physiological responses to CO2 and suggests ecosystem-scale vegetation-climate-CO2 feedbacks that would have influenced water cycling, surface runoff and weatherability, and led to major changes in organic carbon burial, and in turn atmospheric pCO2.
On merger bias and the clustering of quasars
Creators: name: Bonoli, Silvia
name: Shankar, Francesco
name: White, Simon
name: Springel, Volker
name: Wyithe, Stuart
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use the large catalogues of haloes available for the Millennium Simulation to test whether recently merged haloes exhibit stronger large-scale clustering than other haloes of the same mass. This effect could help to understand the very strong clustering of quasars at high redshift. However, we find no statistically significant excess bias for recently merged haloes over the redshift range 2 < z < 5, with the most massive haloes showing an excess of at most ~5%. We also consider galaxies extracted from a semianalytic model built on the Millennium Simulation. At fixed stellar mass, we find an excess bias of ~ 20-30% for recently merged objects, decreasing with increasing stellar mass. The fact that recently-merged galaxies are found in systematically more massive haloes than other galaxies of the same stellar mass accounts for about half of this signal, and perhaps more for high-mass galaxies. The weak merger bias of massive systems suggests that objects of merger-driven nature, such as quasars, do not cluster significantly differently than other objects of the same characteristic mass. We discuss the implications of these results for the interpretation of clustering data with respect to quasar duty cycles, visibility times, and evolution in the black hole-host mass relation.
description: 10 pages, 9 figures. Submitted to MNRAS. Comments welcome
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years
Creators: name: Unwin, David
name: Khalid, Ali Ahsan
name: Unwin, Jen
name: Crocombe, Dominic
name: Delon, Christine
name: Martyn, Kathy
name: Golubic, Rajina
name: Ray, Sumantra
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
diabetes mellitus
dietary patterns
weight management
blood pressure lowering
lipid lowering

description: Background: In a single general practice (GP) surgery in England, there was an eightfold increase in the prevalence of type 2 diabetes (T2D) in three decades with 57 cases and 472 cases recorded in 1987 and 2018, respectively. This mirrors the growing burden of T2D on the health of populations round the world along with healthcare funding and provision more broadly. Emerging evidence suggests beneficial effects of carbohydrate-restricted diets on glycaemic control in T2D, but its impact in a ‘real-world’ primary care setting has not been fully evaluated. Methods: Advice on a lower carbohydrate diet was offered routinely to patients with newly diagnosed and pre-existing T2D or prediabetes between 2013 and 2019, in the Norwood GP practice with 9800 patients. Conventional ‘one-to-one’ GP consultations were used, supplemented by group consultations, to help patients better understand the glycaemic consequences of their dietary choices with a particular focus on sugar, carbohydrates and foods with a higher Glycaemic Index. Those interested were computer coded for ongoing audit to compare ‘baseline’ with ‘latest follow-up’ for relevant parameters. Results: By 2019, 128 (27%) of the practice population with T2D and 71 people with prediabetes had opted to follow a lower carbohydrate diet for a mean duration of 23 months. For patients with T2D, the median (IQR) weight dropped from of 99.7 (86.2, 109.3) kg to 91.4 (79, 101.1) kg, p<0.001, while the median (IQR) HbA1c dropped from 65.5 (55, 82) mmol/mol to 48 (43, 55) mmol/mol, p<0.001. For patients with prediabetes, the median (IQR) HbA1c dropped from 44 (43, 45) mmol/mol to 39 (38, 41) mmol/mol, p<0.001. Drug-free T2D remission occurred in 46% of participants. In patients with prediabetes, 93% attained a normal HbA1c. Since 2015, there has been a relative reduction in practice prescribing of drugs for diabetes leading to a T2D prescribing budget £50 885 per year less than average for the area. Conclusions: This approach to lower carbohydrate dietary advice for patients with T2D and prediabetes was incorporated successfully into routine primary care over 6 years. There were statistically significant improvements in both groups for weight, HbA1c, lipid profiles and blood pressure as well as significant drug budget savings. These results suggest a need for more empirical research on the effects of lower carbohydrate diet and long-term glycaemic control while recording collateral impacts to other metabolic health outcomes.
Anomalous Valley Magnetic Moment of Graphene
Creators: name: Liu, Daqing
name: Zhang, Shengli
name: Zhang, Erhu
name: Ma, Ning
name: Chen, Huawei
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Carrier interactions on graphene are studied. The study shows that besides the well known Coulomb repulsion between carriers, there also exist four-fermion interactions associated with U-process, one of which attracts carriers in different valleys. We then calculate the contributions to valley magnetic moment from vertex correction and from four-fermion corrections explicitly. The relative contributions are -18% and 3% respectively. At last we point out that we can mimic heavy quarkonium system by carrier interactions in graphene.
description: 6 pages, 2 figures
Giant planet migration, disk evolution, and the origin of transitional disks
Creators: name: Alexander, R. D.
name: Armitage, P. J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present models of giant planet migration in evolving protoplanetary disks. Our disks evolve subject to viscous transport of angular momentum and photoevaporation, while planets undergo Type II migration. We use a Monte Carlo approach, running large numbers of models with a range in initial conditions. We find that relatively simple models can reproduce both the observed radial distribution of extra-solar giant planets, and the lifetimes and accretion histories of protoplanetary disks. The use of state-of-the-art photoevaporation models results in a degree of coupling between planet formation and disk clearing, which has not been found previously. Some accretion across planetary orbits is necessary if planets are to survive at radii
description: 13 pages, 9 figures. Accepted for publication in ApJ
Ajapa Natanam of Thiruvarur – A Micro Cosmic Dance
Creators: name: Prof. S. Subbulakshmi
Publisher: name: gjrpublication
Year: 2023

description: It is an Interdisciplinary research article linking Baratanatyama and Astrophysics. Dance has been integral part of the temple worship services in Tamilnadu. Thirumandiram a very early text speaks about Ajapa. Thiruvarur temple is famous for Ajapa natanam where the deity Tyagaraja himself execute this movement of dance. This meditative silence of unuttered prayer (Ajapa)naccompanied by the graceful movements in both vertical and horizontal plane of the Tyagaraja image in synchronization with the vishnu's meditative breath is considered to be the root of this mystical Ajapa natanam. Ajapa is voice less silent Japa represented by inhalation and exhalation of breath. so Ajapa is a rhythmic dance movement which is a gentle, pleasant, fine breathing movement of air. It is quite opposite to the cosmic dance of Nataraja, which is a dance of Universe. So, the movement of Ajapa can be considered as a Microcosmic dance where the rhythmic movement of this Ajapa dance is the up and down movement of the heart with a perfect rhythm. This conscious and controlled breathing of Vishnu is explained as Ajapa natanam. Inhalation and exhalation are the only up and down movements this Ajapa natanam. The cosmic Dance of Nataraja is similar to the cosmic dance of subatomic particle which is observed and analyzed by CERN Scientists. This movement of sub-atomic particle can also be considered as microcosmic dance. Structural Analytical method and comparative method are used.
Watershed ecosystems and human interconnections : a new model for governance in Peachland Creek, B.C.
Creators: name: Kroschinsky, Rheanne
Publisher: name: University of British Columbia
Year: 2023

description: The Peachland Creek watershed within unceded Syilx territory in the Okanagan Valley of British Columbia serves as a prime case study of the challenges faced by many multi-use provincial community watersheds in British Columbia. These challenges include the need for recognition of unrelinquished Syilx rights and title, and management of the cumulative impacts of a changing climate, rapid population growth, tourism, recreational use, ranching, and logging on water quality and the environment. Reflective of a diverse variety of anthropogenic influences, Peachland Creek is governed by a complex jurisdictional and regulatory landscape involving all levels of government (First Nations, municipal, provincial, federal) and their respective agencies. In this light, it stands out as an ideal watershed in which to apply an integrated watershed resource management (IWRM)-based approach, encompassing the above characteristics and distinctive water relationships in a collaborative and inclusive governance framework. Towards this goal, this thesis provides an in-depth examination of the historical and modern socio-ecological context of the Peachland Creek watershed, based on an extensive series of interviews with the local settler population, observational studies in the watershed, and analysis of the legislative, regulatory and policy frameworks guiding decision-making. This research constitutes one component of a larger collaborative, community-engaged study, the Watershed Ecosystems Project (WEP), and incorporates the Syilx perspectives and knowledge contributed by Syilx researchers and communities to that study. This thesis concludes with recommendations for a more appropriate governance model and reflections on the WEP itself as an innovative academic-community partnership model in water governance.
Symmetry properties of vibrational modes in graphene nanoribbons
Creators: name: Gillen, Roland
name: Mohr, Marcel
name: Maultzsch, Janina
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present symmetry properties of the lattice vibrations of graphene nanoribbons with pure armchair (AGNR) and zigzag edges (ZGNR). In non-symmorphic nanoribbons the phonon modes at the edge of the Brillouin zone are twofold degenerate, whereas the phonon modes in symmorphic nanoribbons are non-degenerate. We identified the Raman-active and infrared-active modes. We predict 3N and 3(N+1) Raman-active modes for N-ZGNRs and N-AGNRs, respectively (N is the number of dimers per unit cell). These modes can be used for the experimental characterization of graphene nanoribbons. Calculations based on density functional theory suggest that the frequency splitting of the LO and TO in AGNRs (corresponding to the E2g mode in graphene) exhibits characteristic width and family dependence. Further, all graphene nanoribbons have a Raman-active breathing-like mode, the frequency of which is inversely proportional to the nanoribbon width and thus might be used for experimental determination of the width of graphene nanoribbons.
description: 10 pages, 5 figures
Map #38, Site 5MT10686, Midden 106, Arbitrary Unit 101 and Arbitrary Unit 103, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2019
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: Pueblo III
valueUri: https://core.tdar.org/browse/temporal-keyword/56/pueblo-iii
subject: 5MT10686
valueUri: https://core.tdar.org/browse/site-name/118038/5mt10686
subject: Badger Den
valueUri: https://core.tdar.org/browse/site-name/118037/badger-den

description: Site 5MT10686, Midden 106, Arbitrary Unit 101 and Arbitrary Unit 103, Stratigraphic Profile
Code. Package version
Creators: name: Llinàs Arias, Pere
Publisher: name: figshare
Year: 2023
Subjects: Cancer genetics
Cancer cell biology

description: All analyses were performed using open-source R and Python packages. ATAC-seq read processing was performed using the following software versions: nf-core/atacseq (v1.2.1), Nextflow (v21.04.3), FastQC (v0.11.9), Trim Galore! (v0.6.4_dev), BWA (v0.7.17-r1188), Samtools (v1.10), BEDTools (v2.29.2), BamTools (v2.5.1), deepTools (v3.4.3), Picard (v2.23.1), R (v3.6.2), Pysam (v0.15.3), MACS2 (v2.2.7.1), ataqv (v1.1.1), featureCounts (v2.0.1), Preseq (v2.0.3), MultiQC (v1.9). HiC read processing was performed using the following software versions: nf-core/hic (v1.3.0), Nextflow (v21.10.6), Bowtie2 (v2.3.5.1), Python (v3.7.6), Samtools (v1.9), MultiQC (v1.8). RNA-seq reads processing was performed using the following software versions: bcl2fastq (v2.20.0.422), FastQC (v0.11.9), MultiQC (v1.13.dev0), Fastp (v0.21.0), HISAT2 (v2.2.0), Samtools (v1.10), StringTie (v2.1.4). DESeq2 (1.3.1) was used to calculate differentially expressed genes from RNA-seq and perform PCA analysis. Further data processing was performed using R packages from tydiverse, such as dplyr, tidyr, and ggplot2; pheatmap, rstatix, and viridis. Galaxy servers were also used for ATAC-seq analysis.
Black funnels and droplets from the AdS C-metrics
Creators: name: Hubeny, Veronika E.
name: Marolf, Donald
name: Rangamani, Mukund
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We recently argued that the dynamics of strongly coupled field theories in black hole backgrounds is related via the AdS/CFT correspondence to two new classes of AdS black hole solutions: black funnels, and black droplets suspended above a second disconnected horizon. The funnel solutions are dual to black holes coupling strongly to a field theory plasma. In contrast, the droplet solutions describe black holes coupling only weakly. We continue our investigation of these solutions and construct a wide variety of examples from the AdS C-metric in four bulk spacetime dimensions. The solutions we find are dual to field theories on spatially compact universes with Killing horizons.
description: 25 pages, 7 figures. v2: added refs
ECOFUNCO - Eco sustainable multi Functional biobased Coatings with enhanced performance and end of life options
Creators: name: Cinelli, Patrizia
Publisher: name: Zenodo
Year: 2023

description: Presentation at the "Innovations on Sustainable Materials for Textiles, Coatings, Films and other Wide Use Applications" Conference, organised by BIOnTop Partners European Bioplastics, AIMPLAS, ENCO in Düsseldorf, Maritim Hotel, Thu.11 May 2023, 8.30 am-3.30 pm and online
Longitudinal cohort study of the impact of specialist cancer services for teenagers and young adults on quality of life: outcomes from the BRIGHTLIGHT study
Creators: name: Taylor, Rachel M
name: Fern, Lorna A
name: Barber, Julie
name: Alvarez-Galvez, Javier
name: Feltbower, Richard
name: Lea, Sarah
name: Martins, Ana
name: Morris, Stephen
name: Hooker, Louise
name: Gibson, Faith
name: Raine, Rosalind
name: Stark, Dan P
name: Whelan, Jeremy
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Health services research
1506
1704
organisation of health services
oncology
quality in health care

description: Objectives: In England, healthcare policy advocates specialised age-appropriate services for teenagers and young adults (TYA), those aged 13 to 24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced TYA age-specific care, although many still receive care in adult or children’s cancer services. We present the first prospective structured analysis of quality of life (QOL) associated with the amount of care received in a TYA-PTC Design: Longitudinal cohort study. Setting: Hospitals delivering inpatient cancer care in England. Participants: 1114 young people aged 13 to 24 years newly diagnosed with cancer. Intervention: Exposure to the TYA-PTC defined as patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care. Primary outcome: Quality of life measured at five time points: 6, 12, 18, 24 and 36 months after diagnosis. Results: Group mean total QOL improved over time for all patients, but for those receiving NO-TYA-PTC was an average of 5.63 points higher (95% CI 2.77 to 8.49) than in young people receiving SOME-TYA-PTC care, and 4·17 points higher (95% CI 1.07 to 7.28) compared with ALL-TYA-PTC care. Differences were greatest 6 months after diagnosis, reduced over time and did not meet the 8-point level that is proposed to be clinically significant. Young people receiving NO-TYA-PTC care were more likely to have been offered a choice of place of care, be older, from more deprived areas, in work and have less severe disease. However, analyses adjusting for confounding factors did not explain the differences between TYA groups. Conclusions: Receipt of some or all care in a TYA-PTC was associated with lower QOL shortly after cancer diagnosis. The NO-TYA-PTC group had higher QOL 3 years after diagnosis, however those receiving all or some care in a TYA-PTC experienced more rapid QOL improvements. Receipt of some care in a TYA-PTC requires further study.
Determining equations for higher-order decompositions of exponential operators
Creators: name: Tsuboi, Zengo
name: Suzuki, Masuo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Numerical Analysis (math.NA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The general decomposition theory of exponential operators is briefly reviewed. A general scheme to construct independent determining equations for the relevant decomposition parameters is proposed using Lyndon words. Explicit formulas of the coefficients are derived.
description: 30 pages
Ackerly et al. 2019 International Oaks ms
Creators: name: Ackerly, David
name: Kozanitas, Melina
name: Oldfather, Meagan
name: Prahlad Papper
name: Clark, Matthew
Publisher: name: figshare
Year: 2021
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences
subject: Ecology
subject: 50104 Landscape Ecology
subject: FOS: Earth and related environmental sciences

description: Final manuscript version of: Ackerly, D.D., M. Kozanitas, P. Papper, M. Oldfather, M. Clark. 2019. Mortality and resprouting in California oak woodlands following mixed-severity fire. International Oaks, 30: 23-30.
Joint associations of accelerometer measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals
Creators: name: Ekelund, Ulf
name: Tarp, Jakob
name: Fagerland, Morten W
name: Johannessen, Jostein Steene
name: Hansen, Bjørge H
name: Jefferis, Barbara J
name: Whincup, Peter H
name: Diaz, Keith M
name: Hooker, Steven
name: Howard, Virginia J
name: Chernofsky, Ariel
name: Larson, Martin G
name: Spartano, Nicole
name: Vasan, Ramachandran S
name: Dohrn, Ing-Mari
name: Hagströmer, Maria
name: Edwardson, Charlotte
name: Yates, Thomas
name: Shiroma, Eric J
name: Dempsey, Paddy
name: Wijndaele, Katrien
name: Anderssen, Sigmund A
name: Lee, I-Min
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
2314
accelerometer
sedentary
meta-analysis
death

description: Funder: National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care East Midlands
description: Funder: National Institute on Aging
description: Funder: Stockholms Läns Landsting; FundRef: http://dx.doi.org/10.13039/501100004348
description: Funder: Norwegian Directorate for Public Health
description: Funder: Centrum for Idrottsforskning; FundRef: http://dx.doi.org/10.13039/501100005350
description: Funder: The Coca-Cola Company
description: Objectives: To examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality. Methods: We conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% mortality rate). Associations between different combinations of moderate-to-vigorous intensity physical activity (MVPA) and sedentary time were analysed at study level using Cox proportional hazards regression analysis and summarised using random effects meta-analysis. Results: Across cohorts, the average time spent sedentary ranged from 8.5 hours/day to 10.5 hours/day and 8 min/day to 35 min/day for MVPA. Compared with the referent group (highest physical activity/lowest sedentary time), the risk of death increased with lower levels of MVPA and greater amounts of sedentary time. Among those in the highest third of MVPA, the risk of death was not statistically different from the referent for those in the middle (16%; 95% CI 0.87% to 1.54%) and highest (40%; 95% CI 0.87% to 2.26%) thirds of sedentary time. Those in the lowest third of MVPA had a greater risk of death in all combinations with sedentary time; 65% (95% CI 1.25% to 2.19%), 65% (95% CI 1.24% to 2.21%) and 263% (95% CI 1.93% to 3.57%), respectively. Conclusion: Higher sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40 min of MVPA per day attenuate the association between sedentary time and risk of death, which is lower than previous estimates from self-reported data.
Acceptor and donor impurities in GaN nanocrystals
Creators: name: Echeverría-Arrondo, C.
name: Pérez-Conde, J.
name: Bhattacharjee, A. K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate acceptor and donor states in GaN nanocrystals doped with a single substitutional impurity. Quantum dots (QD's) of zinc-blende structure and spherical shape are considered with the radius ranging from 4.5 to 67.7 A. The size-dependent energy spectra are calculated within the sp3d5s* tight-binding model, which yields a good agreement with the confinement-induced blue shifts observed in undoped QD's. The computed binding energy is strongly enhanced with respect to the experimental bulk value when the dopant is placed at the center of the smallest QD's. It decreases with increasing QD size following a scaling law that extrapolates to the bulk limit. In order to estimate the degree of localization of the bound carriers we analyze their wave functions and average radii. The resulting physical picture points to a highly localized acceptor hole, mostly distributed over the nearest-neighbor anion shell, and a much more extended donor electron. We also study off-center impurities in intermediate-size QD's. The acceptor binding energy is approximately independent of the dopant position unless it is placed within a surface shell of thickness of the order of the bulk Bohr radius, where the ionization energy abruptly drops. On the contrary, the donor binding energy gradually decreases as the impurity is moved away from the center toward the QD surface.
The INTAQT project: tools to assess and authenticate poultry, beef and dairy products
Creators: name: Martin, B.
name: Laithier, C.
name: Leiber, F.
name: Eppenstein, R.
name: Sturaro, E.
name: Klevenhusen, F.
name: De Smet, S.
name: Petracci, M.
name: De Marchi, C.L.
name: Manuelian, C.L.
name: Hocquette, J.F.
name: Lopes, D.
name: Faria Anjos, J.
name: Bondoux, M.
name: Berri, C.
Publisher: name: Zenodo
Year: 2022

description: Actors of the agri-food chain lack reliable and robust information to meet consumer expectations in relation to the multiple aspects of intrinsic quality of livestock products from the various European livestock systems. The INTAQT project aims to assess the relationships between animal production systems and products quality in order to improve husbandry practices complying with high quality animal products and sustainability. This is the ‘One Quality’ concept. The project focuses on chicken meat, beef, and dairy products and applies a multi-actor participatory approach which involves all actors of the agri-food chain. The challenges are to: (1) develop comprehensive models to quantify the impact of livestock systems on product safety, nutritional value and sensory attributes; (2) propose, together with the agri-food chain actors, fast, easy and cost-effective analytical tools to predict the intrinsic quality of livestock products and authenticate the associated livestock systems; (3) propose together with the same actors multi-criteria scoring tools for the intrinsic quality of products; and (4) promote farming practices which can allow the production of safe, healthy and tasty animal products while ensuring a decent income to farmers and respecting animal welfare and the environment. The INTAQT project (EU H2020 No 101000250 – https://h2020-intaqt.eu/) started on June 2021 for 5 years.
Additional file 2 of Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats
Creators: name: Ye, Jian
name: Xiao, Rongxue
name: Wang, Xu
name: He, Ruiqing
name: Liu, Zongjun
name: Gao, Junqing
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 2. (Original blot images).
Experience of point-of-care HbA1c testing in the English National Health Service Diabetes Prevention Programme: an observational study
Creators: name: Barron, Emma
name: Misra, Shivani
name: English, Emma
name: John, W Garry
name: Sampson, Michael
name: Bachmann, Max O
name: Barth, Julian
name: Oliver, Nick
name: Alberti, K G M M
name: Bakhai, Chirag
name: O'Neill, Simon
name: Young, Bob
name: Wareham, Nicholas J
name: Khunti, Kamlesh
name: Jebb, Susan
name: Smith, Jenifer
name: Valabhji, Jonathan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Epidemiology/Health services research
1506
1867
primary prevention
diabetes mellitus, type 2
point-of-care systems

description: Introduction: To report the observations of point-of-care (POC) glycated hemoglobin (HbA1c) testing in people with non-diabetic hyperglycemia (NDH; HbA1c 42–47 mmol/mol (6.0%–6.4%)), applied in community settings, within the English National Health Service Diabetes Prevention Programme (NHS DPP). Research design and methods: A service evaluation assessing prospectively collected national service-level data from the NHS DPP, using data from the first referral received in June 2016–October 2018. Individuals were referred to the NHS DPP with a laboratory-measured HbA1c in the NDH range and had a repeat HbA1c measured at first attendance of the program using one of three POC devices: DCA Vantage, Afinion or A1C Now+. Differences between the referral and POC HbA1c and the SD of the POC HbA1c were calculated. The factors associated with the difference in HbA1c and the association between POC HbA1c result and subsequent attendance of the NHS DPP were also evaluated. Results: Data from 73 703 participants demonstrated a significant mean difference between the referral and POC HbA1c of −2.48 mmol/mol (−0.23%) (t=157, p<0.001) with significant differences in the mean difference between devices (F(2, 73 700)=738, p<0.001). The SD of POC HbA1c was 4.46 mmol/mol (0.41%) with significant differences in SDs between devices (F(2, 73 700)=1542, p<0.001). Participants who were older, from more deprived areas and from Asian, black and mixed ethnic groups were associated with smaller HbA1c differences. Normoglycemic POC HbA1c versus NDH POC HbA1c values were associated with lower subsequent attendance at behavioral interventions (58% vs 67%, p<0.001). Conclusion: POC HbA1c testing in community settings was associated with significantly lower HbA1c values when compared with laboratory-measured referrals. Acknowledging effects of regression to the mean, we found that these differences were also associated with POC method, location, individual patient factors and time between measurements. Compared with POC HbA1c values in the NDH range, normoglycemic POC HbA1c values were associated with lower subsequent intervention attendance.
Map #36, Site 5MT10686, Masonry Surface Room 111, Nonstructure 114, and Arbitrary Unit 113, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2019
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: Pueblo III
valueUri: https://core.tdar.org/browse/temporal-keyword/56/pueblo-iii
subject: 5MT10686
valueUri: https://core.tdar.org/browse/site-name/118038/5mt10686
subject: Badger Den
valueUri: https://core.tdar.org/browse/site-name/118037/badger-den

description: Site 5MT10686, Masonry Surface Room 111, Nonstructure 114, and Arbitrary Unit 113, Stratigraphic Profile
Ackerly et al. 2019 International Oaks ms
Creators: name: Ackerly, David
Publisher: name: figshare
Year: 2021
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences
subject: Ecology
subject: 50104 Landscape Ecology
subject: FOS: Earth and related environmental sciences

description: Final manuscript version of: Ackerly, D.D., M. Kozanitas, P. Papper, M. Oldfather, M. Clark. 2019. Mortality and resprouting in California oak woodlands following mixed-severity fire. International Oaks, 30: 23-30.
Detectability of Transiting Jupiters and Low-Mass Eclipsing Binaries in Sparsely Sampled Pan-STARRS-1 Survey Data
Creators: name: Dupuy, Trent J.
name: Liu, Michael C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present detailed simulations of the Pan-STARRS-1 (PS1) multi-epoch, multi-band 3-pi Survey in order to assess its potential yield of transiting planets and eclipsing binaries. This survey differs from dedicated transit surveys in that it will cover the entire Northern sky but provide only sparsely sampled light curves. Since most eclipses would be detected at only a single epoch, the 3-pi Survey will be most sensitive to deep eclipses (> 0.10 mag) caused by Jupiters transiting M dwarfs and eclipsing stellar/substellar binaries. The survey will also provide parallaxes for the ~400,000 stars within 100 pc which will enable a volume-limited eclipse search, reducing the number of astrophysical false positives compared to previous magnitude-limited searches. Using the best available empirical data, we constructed a model of the extended solar neighborhood that includes stars, brown dwarfs, and a realistic binary population. We computed the yield of deeply eclipsing systems using both a semi-analytic and a full Monte Carlo approach. We examined statistical tests for detecting single-epoch eclipses in sparsely sampled data and assessed their vulnerability to false positives due to stellar variability. Assuming a short-period planet frequency of 0.5% for M dwarfs, our simulations predict that about a dozen transiting Jupiters around low-mass stars (M < 0.3 Msun) within 100 pc are potentially detectable in the PS1 3-pi Survey, along with ~300 low-mass eclipsing binaries (both component masses < 0.5 Msun), including ~10 eclipsing field brown dwarfs. Extensive follow-up observations would be required to characterize these candidate eclipsing systems, thereby enabling comprehensive tests of structural models and novel insights into the planetary architecture of low-mass stars.
description: ApJ, in press
The influence of playgrounds on children’s health: a Scoping Review Protocol
Creators: name: Madsen, Cathrine
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Medicine and Health Sciences
subject: Adolescents
subject: Children
subject: Children's health
subject: Physical activity
subject: Play
subject: Playgrounds

description: Many studies indicate that playgrounds can play an important role in children’s development and physical activity. However, knowledge on the influence of playgrounds on children health is fragmented and a coherent overview of relevant research is lacking. Studies addressing the influence of playgrounds on health are carried out in many different research fields with varying study designs, methods, and outcomes. Existing reviews on the relation between playgrounds and health have focused on specific age groups, a specific context (e.g. schoolyards or parks), or a specific health outcome (e.g. physical activity or motor skills). We want to create a global, interdisciplinary overview of all research that is relevant when studying the influence of playgrounds on children’s health to be able to identify potential synergies between research fields and research groups, identify research gaps, and set the agenda for future research. Since we do not want to limit the overview to a specific field, age group, outcome, or study design, we will conduct a comprehensive scoping review.
MECHANISMS MEDIATING REPLICATION FORK COLLAPSE AND PROCESSING IN CHECKPOINT DEFECTIVE CELLS
Creators: name: COLOSIO, ARIANNA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: ABSTRACT An accurate DNA replication is essential to prevent genome instability events, such as mutations and chromosomal rearrangements that are hallmarks of neoplastic transformation and cancer onset. A dedicated branch of the DNA damage checkpoint maintains the integrity of replicating chromosomes by stabilising replication forks in the presence of genotoxic agents, thus ensuring cell viability. Upon fork collapse, budding yeast checkpoint mutants experiencing replication stress accumulate aberrant replication intermediates, such as gapped and hemireplicated molecules, as well as four-branched structures known as reversed forks. Aberrant replication intermediates are potentially harmful for the cells since they are thought to trigger unscheduled recombination events that cause genome rearrangements. In this PhD thesis, I examined checkpoint-dependent mechanisms controlling fork stability, and I provide in vivo evidence that positive supercoiling accumulating ahead of replication forks is the main mechanical force driving fork reversal. Thus, DNA topology is a critical determinant of replication fork stability in vivo. Furthermore, a 2D-gel screening for enzymatic activities involved in the metabolism of collapsed forks, revealed a novel role for the Sae2 and Dna2 endonucelases in replication intermediates processing.
Perceptions of a dietary self-monitoring mobile app resembling the Canada’s food guide : a qualitative study
Creators: name: Kheirmandparizi, Maryam
Publisher: name: University of British Columbia
Year: 2023

description: Background and Purpose: Dietary self-monitoring is a behavioural technique that helps to elicit and sustain dietary changes over time. Current dietary self-monitoring tools focus on itemizing foods and serving sizes (portions), making them complex, time-consuming, and hard to use for people with limited or low health literacy. Furthermore, there are no plate-based dietary self-monitoring tools that conform to the 2019 Canada Food Guide (CFG). This thesis explored the perceptions of potential end-users (i.e., members from the general public) and Registered Dietitians (RDs) on a dietary self-monitoring mobile application (app) resembling the CFG, called iCANPlateᵀᴹ. Methods: Qualitative data were collected through virtual focus groups. Questions in the focus group guide were based on the Capability, Opportunity, Motivation- Behaviour (COM-B) model to explore perceptions of using the CFG and available dietary self-monitoring tools. A prototype of iCANPlateᵀᴹ (version 0.1) was presented to gain feedback on perceived barriers and facilitators to using the app, and suggestions on future versions. Trained researchers used transcripts of audio-recorded focus groups to conduct thematic analysis. Results: Seven focus groups with RDs (n=44) and nine focus groups with members from the general public (n=52) were conducted. During the focus groups, participants discussed potential facilitators and barriers to using the current iteration of iCANPlate. They were interested in the simplicity of iCANPlate and its capacity to foster self-awareness of dietary behaviours rather than weight or calorie counting. However, concerns were raised regarding iCANPlate’s potential to improve adherence to dietary self-monitoring, primarily caused by a lack of food classifications, conceptualizing proportions, and lack of inclusivity. In addition, participants suggested necessary and optional components for iCANPlate’s future versions. Conclusions: Overall, participants liked the simplicity of iCANPlate and its ability to promote self-awareness of dietary intakes, primarily through visual representation of foods on a plate as opposed to reliance on numerical values or serving sizes. Findings from this study will be used to further develop the app with the goal of increasing adherence to plate-based dietary approaches.
Effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low and middle-income countries: a systematic review protocol
Creators: name: Nnaji, Chukwudi Arnest
name: Kuodi, Paul
name: Walter, Fiona M
name: Moodley, Jennifer
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Oncology
1506
1717
oncology
breast imaging
health services administration & management
public health

description: Introduction: Breast and cervical cancers pose a major public health burden globally, with disproportionately high incidence, morbidity and mortality in low- and middle-income countries (LMICs). The majority of women diagnosed with cancer in LMICs present with late-stage disease, the treatment of which is often costlier and less effective. While interventions to improve the timely diagnosis of these cancers are increasingly being implemented in LMICs, there is uncertainty about their role and effectiveness. The aim of this review is to systematically synthesise available evidence on the nature and effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in LMICs. Methods and analysis: A comprehensive search of published and relevant grey literature will be conducted. The following electronic databases will be searched: MEDLINE (via PubMed), Cochrane Library, Scopus, CINAHL, Web of Science and the International Clinical Trials Registry Platform (ICTRP). Evidence will be synthesised in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). Two reviewers will independently screen the search outputs, select studies using predefined inclusion criteria and assess each included study for risk of bias. If sufficient data are available and studies are comparable in terms of interventions and outcomes, a meta-analysis will be conducted. Where studies are not comparable and a meta-analysis is not appropriate, a narrative synthesis of findings will be reported. Ethics and dissemination: As this will be a systematic review of publicly available data, with no primary data collection, it will not require ethical approval. Findings will be disseminated widely through a peer-reviewed publication and forums such as conferences, workshops and community engagement sessions. This review will provide a user-friendly evidence summary for informing further efforts at developing and implementing interventions for addressing delays in breast and cervical cancer diagnosis in LMICs. PROSPERO registration number: CRD42020177232.
Deep Big Simple Neural Nets Excel on Handwritten Digit Recognition
Creators: name: Ciresan, Dan Claudiu
name: Meier, Ueli
name: Gambardella, Luca Maria
name: Schmidhuber, Juergen
Publisher: name: arXiv
Year: 2010
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Good old on-line back-propagation for plain multi-layer perceptrons yields a very low 0.35% error rate on the famous MNIST handwritten digits benchmark. All we need to achieve this best result so far are many hidden layers, many neurons per layer, numerous deformed training images, and graphics cards to greatly speed up learning.
description: 14 pages, 2 figures, 4 listings