cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metodologie per la valutazione delle caratteristiche di un propellente solido
Evaluation and characterization of a solid rocket propellant
Creators: name: Fedele, Domenico <1989>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: ING-IND/08 Macchine a fluido

description: Questo lavoro di dottorato, svolto prevalentemente presso i laboratori hangar della Facoltà di Ing. Aerospaziale di Forlì, in collaborazione con AVIO S.P.A (Colleferro), ha come scopo quello di ricostruire alcune grandezze tipiche di un motore per razzi a propellente solido. In particolare è stato sviluppato un algoritmo in MatLab, successivamente "tradotto" in C++ per evidenti motivi di velocità computazionale, capace di prevedere la frazione volumetrica di un propellente bi-modale. Successivamente, sulla base di
questo parametro, e utilizzando informazioni relative alla composizione completa del propellente stesso, si è andati a defnire un "Margine di Colabilità",capace di legare la viscosità cinematica del composto alla sua stessa composizione granulometrica. Infne si è cercato di fruttare queste informazioni per vedere come questi parametri, insieme all'orientazione e concentrazione delle particelle stesse, possono influenzare il proflo di pressione durante la fase di lancio, e cercare quindi di spiegare il così detto effetto HUMP (disuniformità della velocità di combustione internamente al grain)
description: This doctoral dissertation has been carried out in the laboratories based in the hangar of the Engineering Faculty of Forlì, University of Bolonia, in cooperation with AVIO S.P.A. (Colleferro). The aim of the thesis is to reconstruct some typical characteristics of a solid rocket motor. The work is particularly focused on the development of an algorithm - using MatLab - that has later been "translated" into C++ in order to reduce the computational load and to be able to predict the volume fraction of a bi-modal propellant. Later, using this parameter, as well as some informations concerning the full composition of the propellant, the "castability margin" has been defined, in order to link its cinematic viscosity to the related propellant formulation. Lastly, the informations collected has been exploited to figure out how these parameters, together with the particles' orientation and concentration, may influence the pressure profile during the launch phase. This data tries to explain the so-called HUMP effect (inhomogeneity of the combustion speed inside the grain)
Opportunities for exploitation of Earth observation data to inform risk management of ocean tipping points
Creators: name: Wood, Richard
name: Conversi, Alessandra
name: Donner, Reik
name: Angela, Landolfi
name: Anastasia, Romanou
name: Stocker, Thomas
name: Swingedouw, Didier
name: Maslowski, Wieslaw
Publisher: name: Zenodo
Year: 2025

description: This note summarises ideas for the exploitation of EO data to move forward the science of ocean tipping points, with the goal of enabling societies to better manage the risks associated with such events. It is the result of discussions among the authors at the ISSI Workshop Tipping Points and Understanding EO data needs, held in Bern in October 2022.
Supplementary document for Computational study of the effects of “defective” plasmonic metal nanoparticle arrays on the optoelectronic performance of thin-film solar cells - 6346913.pdf
Creators: name: Haque, Abrar Jawad
name: Al Suny, Asif
name: Bin Sultan, Rifat
name: Khan, Tawseef Ahmed
name: Chowdhury, Mustafa
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised Supplemental Document-"Supplement 1". Please use this updated supplemental document with manuscript.
title: Letters: Omer Hirst, Charles R. Fenwick, and Douglas B. Fugate, June 1, 1965-June 8, 1965
Creators: name: Hirst, Omer
name: Fenwick, Charles R.
name: Hair, Albert M.
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Traffic
subject: Transportation

description: Letter A: 6 pgs, typescript signed, 11" x 8.5" (27.9 cm x 21.6 cm); Letter B: 1 pg, typescript unsigned, 11" x 8.5" (27.9 cm x 21.6 cm)
description: Letter A from Sen. Omer Hirst to Sen. Charles R. Fenwick regards the need of two underpasses in Alexandria (VA) under Shirley Highway. Enclosed with Hirst's letter is a copy of a letter sent to him by City of Alexandria Manager Albert M. Hair, Jr. and copies of letters letters by Hirst to Hon. George C. Landrith and Virginia Department of Highways Commissioner Douglas B. Fugate, all regarding the same subject. Letter B is from Sen. Fenwick to Fugate imploring him to consider the Shirley Highway underpasses. C. Harrison Mann, Jr. Collection 35.02
Navigating New Frontiers: Artists in the 21st Century. Meet Olivia Ingle
Creators: name: Sangines, Claudia
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 360101
subject: Art criticism
classificationCode: 360102
subject: Art history
classificationCode: 360602
subject: Fine arts

description: In this paper, we explore Olivia Ingle’s art and will leave you with the interview. Olivia's work combines figurative art with mastery of perspective, shadows, and contrasts. Her landscapes connect deeply with nature, while her surreal and abstract pieces explore psychedelic dimensions. Influenced by William Blake, her art balances masculine and feminine elements, aiming to evoke spiritual strength and conscious awareness.
title: Transcranial Magnetic Stimulation Investigation of the Frontoparietal Attention Network
Creators: name: Shelp, Adam K
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Attention
subject: Dynamic Attending Theory
subject: Frontoparietal attention network
subject: Transcranial magnetic stimulation
subject: Right anterior temporoparietal junction
subject: Right ventral intraparietal sulcus

description: Dynamic Attending Theory (DAT) suggests that, due to its exorbitant energy requirements, attention regularly oscillates such that an individual experiences high and low energetic states during sustained attending that lead to high and low mental presences, respectively. Attention research is largely focused on endogenous temporal orienting, however, so little is known about the neural mechanisms underlying exogenous orienting as specified by DAT. We used TBS to inhibit the right ventral intraparietal sulcus and right anterior temporoparietal junction during a dynamic attending task to directly observe their roles in attentional entrainment. We found a significant effect of Foreperiod, but likely due to low sample size, we found no significance of IOI, the interaction between the two, or stimulation site. These findings warrant additional research, to determine how inhibition compares to a control site and to increase power in the hopes of replicating the results of Sanabria, Capizzi, and Correa (2011).
title: War Planning and Effective Military Organizations
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: Military organizations devote substantial attention to pre-war planning. This is not surprising given the uncertainties associated with preparing for the next war, as well as the enduring influence of President Eisenhower’s dictum on the importance of planning. But just because planning is occurring does not mean that it is producing anything useful. Does pre-war planning really make a difference in terms of wartime military effectiveness? In this dissertation, I find that it does, but not always in positive ways. I argue that military planning organizations that adopt five pre-war planning practices are most likely to produce war planning outcomes that contribute to higher levels of military effectiveness: specificity, resource-sensitivity, moderate civilian oversight, external collaboration, and strategic education. I put the argument to an empirical test by examining the implications of German, French, and British war planning from 1905-1914, to these states’ experiences during the July-August 1914 crisis and initial operational phase of the First World War.
Nonlinear Characterization and Modeling of Radio-Frequency Devices and Power Amplifiers with Memory Effects
Creators: name: Gibiino, Gian Piero <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: ING-INF/01 Elettronica

description: Despite the fast development of telecommunications systems experienced during the last two decades, much progress is expected in the coming years with the introduction of new solutions capable of delivering fast data-rates and ubiquitous connectivity. However, this development can only happen through the evolution of radio-frequency systems, which should be capable of working at high-power and high-speed. At the same time, the power dissipation of these systems should be minimized. In this dissertation, methods for the characterization and modeling of transistors and power amplifiers are presented, along with the necessary nonlinear measurements techniques. In particular, dynamic electrical effects, originated by the properties of the semiconductor materials and by the system configurations, are investigated. Consequently, these phenomena, which cannot be ignored to obtain the wanted performance, are empirically identified and included in models for Gallium Nitride (GaN) transistors and power amplifiers driven by a dynamic voltage supply.
ESEO spacecraft: FMEA (Failure Mode and Effects Analysis) and FDIR (Fault Detection Isolation and Recovery)
FMEA (Failure Mode Effects Analysis) ed FDIR (Fault Detection Isolation and Recovery) per la piattaforma satellitare E.S.E.O.
Creators: name: Ferroni, Matteo Alberto <1985>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: ING-IND/03 Meccanica del volo

description: The purpose of the present doctoral activities concern the reliability of electronic systems and their fault tolerance. The main field of application whose is addressed this research is the aerospace industry, in particular it has been developed around the E.S.E.O. (European Student Earth Orbiter) spacecraft/mission. The implementation of COTS (Components Off The Shell) electronic components, military industrial grade, ensured a considerable saving in terms of costs with minimal impact on the final performance of the system. In order to reach the objective: the mission success (operative spacecraft for at least six months), it has been performed an FMEA analysis at system and subsystem level and a full test campaign useful to define and develop the hierarchical and distributed FDIR strategy here exposed.
Turbulent Diffusion of the Geomagnetic Field and Dynamo Theories
Creators: name: Filippi, Enrico <1983>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: GEO/10 Geofisica della terra solida

description: The thesis deals with the Dynamo Theories of the Earth’s Magnetic Field and mainly deepens the turbulence phenomena in the fluid Earth’s core. Indeed, we think that these phenomena are very important to understand the recent decay of the geomagnetic field. The thesis concerns also the dynamics of the outer core and some very rapid changes of the geomagnetic field observed in the Earth’s surface and some aspects regarding the (likely) isotropic turbulence in the Magnetohydrodynamics. These topics are related to the Dynamo Theories and could be useful to investigate the geomagnetic field trends.
Supplementary document for Label-free and dynamic monitoring of cell evolutions using wavelength-multiplexing surface plasmon resonance holographic microscopy - 6346919.pdf
Creators: name: Dai, Siqing
name: Mi, Jingyu
name: Dou, Jiazhen
name: Shi, Wenpu
name: Zhang, Jiwei
name: Zhao, Jianlin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
title: Poster: George Mason University School of Management, ca. 2006
Creators: name: University, George Mason
Publisher: name: George Mason University
Year: 2006
Subjects: subject: George Mason University
subject: Basketball
subject: George Mason School of Management

description: Poster: color, 11" x 17" (27.9 cm x 43.2 cm)
description: "School of Management 'Heart' Patriots" poster displayed on campus. The word "Sports" is inscribed in ink at top right. 2005-06 Men's Basketball Season and Tournament Run Collection
Drivers of Continental Margin Growth. Examples from the Quaternary Adriatic Basin
Creators: name: Pellegrini, Claudio <1984>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: GEO/02 Geologia stratigrafica e sedimentologica

description: The growth of continental margins typically results in the development of large-scale sedimentary units 
with sigmoidal-shaped profiles, termed clinothems. Clinothems occur at a variety of spatial and temporal 
scales, are recognized from shelfal to basin regions and represent one of the fundamental building blocks of 
prograding successions. This Ph.D. thesis is based on four datasets from different case histories along an 
hypothetical sediment routing system of the Adriatic continental margin. The main goal of this Ph.D. thesis is to 
investigate how the interaction of allogenic and autogenic processes impacts on river morphodynamics and 
drives clinothems development and growth, and ultimately the formation of modern continental margins. 
The first case history is a portion of the Po River upstream the Isola Serafini dam. This area may be considered as 
a natural laboratory  where investigate and quantify the impact of the backwater effect on river morphodynamics. The second  case history is the Mid Adriatic Deep during the Last Glacial Maximum, where a 350m thick succession developped in a very short-time window. This area allows to investigate the internal architecture, geometric relation and facies distribution of a lowstand delta. The third case history, offshore the Gargano Promontory, offers the possibility to investigate how genetically-related coastal and subaqueous progradations, i.e. a compound delta, may develop at sub-millennial time scale. The fourth case history, the southern Adriatic Basin, gives opportunity to investigate the impact of the oceanographic regime on sediment transport, where, far from direct sediment feeding sources, lateral advection and current deposition became the dominant mechanism of margin progradation. 
Working on the Adriatic Quaternary succession it was possible to document the effect of a paramount control on margin feed and progradation, to discriminate short-lived phases of extremely rapid deposition during the margin construction, and to document the importance of oceanographic processes on margin growth.
title: Possible Effects of the Loop Current on Intensity and Rapid Intensification of Hurricanes in the Gulf of Mexico
Creators: name: Young, Sherry L
Publisher: name: George Mason University
Year: 2019
Subjects: subject: Hurricanes
subject: Katrina
subject: Rita
subject: Dennis
subject: Lili
subject: Gulf of Mexico
subject: Loop Current
subject: Rapid intensification
subject: Tropical cyclones

description: Increasing population in coastal communities is putting more lives and property at risk from hurricanes. A great need exists for a better understanding of hurricane intensity and rapid intensification; especially if frequency and intensity could increase because of warming oceans. Eleven Gulf of Mexico hurricanes and their fluctuations in intensity relative to proximity to the Loop Current, ocean heat content, depth to the 26°C isotherm, and SST were investigated. ESRI ArcMap was utilized to map and relate hurricane and ocean surface layer data obtained by satellite, reanalysis products, and National Hurricane Center observations. 164 data points were binned to sort by proximity to the Loop Current and to isolate other factors such as eyewall replacement cycles and wind shear. Linear regression was used to calculate correlations between variables and intensity, percent of maximum potential intensity, and to calculate probability of rapid intensification. Katrina had the best correlation between sustained wind speed and ocean heat content at 91% during rapid intensification episodes. During favorable conditions, data points with the highest sustained wind speeds of 250 km/hr or more and that reached 100% of maximum potential intensity occurred where sea surface temperature was 29.75°C or greater, depth to the 26°C isotherm was 50 m or more, and tropical cyclone heat potential was 90 kJ/cm² or more. Hurricanes over the Loop Current had a greater probability of intensifying at 39% and undergoing rapid intensification at 26.5%, compared to those over Gulf common water where ~25% intensified and ~17% rapidly intensified, and had less of a probability of de-intensifying during both favorable and unfavorable conditions. During favorable conditions, hurricanes over the Loop Current intensified ~62% and rapidly intensified ~57% of the time while those over Gulf common water intensified ~48% and rapidly intensified ~40% of the time. Results suggest that increased ocean heat content and depth to the 26°C isotherm in the Loop Current limits surface cooling due to mixing permitting additional intensification during favorable conditions.
The Microbiome and Cancer Unveiling the Microbe-Tumor Crosstalk
Creators: name: Lamlom Tahawy, Lamlom Taie
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 321101
subject: Cancer cell biology
classificationCode: 320601
subject: Gene and molecular therapy
classificationCode: 400603
subject: Molecular, biological, and multi-scale communications

description: With more and more evidence showing that gut microbiota significantly affects tumour biology, the complex relationship betweenthe human microbiome and cancer has attracted a lot of attention. The aim of this study is to introduce an innovative theoreticalframework that integrates information from microbiology, immunology, oncology, and bioinformatics in order to enhance our understanding of the interactions between microorganisms and tumours. The introduction provides a thorough summary of the humanmicrobiome while highlighting the important role it plays in the development of pathogenic disorders. Moreover, it offers a succinctoverview of key concepts in cancer biology, emphasising the significance of examining the relationship between the microbiomeand illnesses associated with cancer. An exhaustive literature analysis compiles the foremost discoveries about the impact of themicrobiome on cancer. It provides an explanation of how mechanisms such as metabolic relationships, immunological regulation,and inflammatory pathways function. Lastly, it highlights the deficiencies in existing research that necessitate the implementationof more comprehensive methods. The results show that the gut microbiota may affect the growth of tumours in certain ways, suchas by changing the immune system, signalling pathways, and bacterial products. Methodological approaches encompass a thoroughexamination of existing literature, the integration of fundamental ideas, and the creation of a comprehensive model that visuallyrepresents these intricate relationships. We evaluate the framework's accuracy by generating predicted scenarios and analyzingthe possible consequences for clinical practice and research. We propose new diagnostic indicators and therapeutic techniques thatspecifically target the microbiome
title: Paper: Anonymous, "Relationship to HUD Goals," January, 1978
Creators: name: Anonymous
Publisher: name: George Mason University
Year: 2006
Subjects: subject: U.S. Department of Housing and Urban Development (HUD)

description: Textual: Paper, copy; 10.5” x 8” (25.4 cm x 21.6 cm)
description: Anonymous paper entitled "Relationship to HUD Goals" and dated January 1978. This paper discusses the Housing Assistance Plan of Port Arthur, Texas. It is divided into three sections. Also included is what appears to be an earlier draft of this paper dated September 1977; the title of this paper is "HUD Goals and Sub-Goals," and it contains five sections. Planned Community Archives Collection, 483.11
Analysis of the FADN system implementation in the Republic of Serbia
Creators: name: Ivkov, Ivana <1980>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: AGR/01 Economia ed estimo rurale

description: One among many other preconditions in the field of agriculture for Serbia’s accession to the EU is establishment of the Farm Accountancy Data Network (FADN) system. It can improve both on-farm and agricultural policy decision making processes by providing valuable information on physical, structural, economic and financial data. 
Republic of Serbia does not have farm accounting legal base and therefore the agricultural hold-ers are not obliged to keep records in order to have accurate income calculations. 
In line with this, Serbian FADN system has been established.
As a consequence to aforementioned, this deliverable is an earliest attempt to examine the use-fulness and suitableness of the FADN system implementation in the Republic of Serbia. 
The applied EU FADN methodology is described, clarifying the basic definitions (universe of agri-cultural holdings, field of observation, sample selection, standard output, etc.). Harmonization and application of this methodology in the Republic of Serbia is described as well. 
In this research it was observed Serbian FADN life cycle from 2012 to 2015, with the main focus on 2013.
Comparative research method was used in a particular areas of this study, which aimed to make comparisons across different FADN organizational infrastructures of certain EU Member States and Republic of Serbia, as well as to make comparisons of the first Serbian FADN results with the same results of a few selected EU Member States.
In the pre-conclusion section the emphases is given on SWOT analyses, which gives an assessment of the FADN system implementation in the EU and in the Republic of Serbia. In addition to this, recommendations are given in order to achieve better FADN system implementation in the Repub-lic of Serbia.
Research findings indicated that the Serbian FADN system is still under development, faces many challenges, and needs to be further improved and strengthened.
Real-World Choreographies
Creators: name: Giallorenzo, Saverio <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: INF/01 Informatica

description: Choreographies are a relatively new tool for designing distributed systems from a global viewpoint. Moreover, choreographies are also free from deadlocks and race conditions by design. Recent theoretical results defined proper Endpoint Projection (EPP) functions to compile choreographic specifications into their single components. Since EPPs are behavioural preserving, projected systems also enjoy freedom from deadlocks and races by construction. 

Aim of this PhD is to formalise non-trivial features of distributed systems with choreographies and to translate our theoretical results into the practice of implemented systems. To this purpose, we provide two main contributions.

The first contribution tackles one of the most challenging features of distributed development: programming correct and consistent runtime updates of distributed systems. Our solution is a theoretical model of dynamic choreographies that provides a clear definition of which components and behaviours can be updated. We prove that compiled choreographic specifications are correct and consistent after any update. We also refine our theoretical model to provide a finer control over updates. On this refinement, we develop a framework for programming adaptable distributed systems.

The second contribution covers one of the main issues of implementing theoretical results on choreographies: formalising the compilation from choreographies to executable programs. There is a sensible departure between the present choreographic frameworks and their theoretical models because their theories abstract communications with synchronisation on names (a la CCS/π-calculus) yet they compile to Jolie programs, an executable language that uses correlation — a renown technology of Service-Oriented Computing — for message routing. Our solution is a theory of Applied Choreographies (AC) that models correlation-based message passing. We pinpoint the key theoretical problems and formalise the principles that developers should follow to obtain correct implementations. Finally, we prove our approach by defining a correct compiler from AC to the calculus behind the Jolie language.
title: Variational and quasi-variational problems with gradient constraints and applications to sandpile growth
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2021

description: In this dissertation, we study variational inequalities (VIs) and quasi-variational inequalities (QVIs) with gradient constraints in diffusive and non-diffusive settings together with several related problems. Specifically, we consider evolutionary, as well as stationary versions of the aforementioned problems, and address existence and uniqueness of solutions, differentiability properties in the context of optimal control, and rigorous Fenchel dualization approaches under low regularity of the data. Initially, we address features of the prototypical problem under study: The Prigozhin model of sandpile growth. In particular, we establish an illustrating example and show closed forms for its multiple solutions and prove that the elementary regularization of constraints leads to uniqueness. On the class of problems arising from the semi-discretization of the evolutionary version, we study existence of solutions under low regularity assumptions; we analyze the cases where the bounds of the gradient constraints are non-negative integrable functions, and also Borel measures. In the latter, we identify new mathematical tools for the application of the direct method. A complete characterization of the Fenchel pre-dual problem leads to the study of minimization problems in a non-standard state space given by vectorial Borel measures with square integrable divergences. The duality description is then exploited for the development of a primal-dual solution algorithm and numerical tests are shown. For a stationary problem formulation which includes a diffusive operator,we provide novel results on the Newton differentiability of the control-to-state map. This is of interest in the investigation of sensitivity features and optimal control. In this framework, the control is the material source term and the state corresponds to the stationary shape of the material pile. The mathematical enabling tool here is a new implicit function theorem for Newton differentiable maps. In the evolutionary sandpile growth setting, an optimal control problem with a QVI as constraint, is considered. The main goal in this problem is to keep a part of the domain free of material accumulation by controlling the initial supporting surface. We consider fully discrete and semi-discrete approaches for this problem and provide an existence of solutions result.
Scaffold funzionali per il differenziamento condrogenico di cellule staminali mesenchimali umane
Functional scaffold for chondrogenic differentiation of human mesenchymal stem cells
Creators: name: Focaroli, Stefano <1982>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: BIO/16 Anatomia umana

description: L'ingegneria tissutale è un campo multidisciplinare in rapida crescita che si avvale delle scienze fisiche, ingegneristiche e della vita per sviluppare ed ottenere cellule funzionali, tessuti ed organi per riparare, sostituire o migliorare le funzioni biologiche perse a causa di anomalie congenite, traumi, malattie o invecchiamento. Nell’ambito della ricostruzione della cartilagine articolare sono stati fatti notevoli passi in avanti ma la soluzione per il ripristino completo del tessuto sembra ancora essere lontana. 
Nella prima parte di questo lavoro è stata valutata la capacità di uno scaffold a base di gelatina di indirizzare le ADSCs verso un differenziamento in senso condrogenico. Successivamente, con lo scopo di migliorare il grado differenziamento e diminuire i costi associati all’utilizzo di fattori differenziativi, l’attenzione è stata posta sullo sviluppo di un biomateriale a base di alginato e ioni cobalto in modo da mimare e sfruttare le caratteristiche fisiche della cartilagine piuttosto che il suo intorno chimico. In ultimo, è stato sviluppato un sistema low cost per la produzione di chip microfluidici sfruttabili per la realizzazione di sistemi micrometrici per incapsulazione cellulare.
description: Tissue engineering is an interdisciplinary and multidisciplinary field that aims at the developmentof biological substitutes that restore, mantain, or improve tissue function. Concerning the articular cartilage many improvments were made, but the complete tissue restoration approach still lacking.
In the first part of this work, it was evaluated the ability of a gelatin scaffold to promote the condrogenic differentiation of ADSCs. Successively, in order to obtain a low cost sistem, a based alginate/Cobalt scaffold was designed with the aim to take advantage of the physical features of the cartilage tissue. Finally, it was developted a cost effective method to produce microfluidic chips with the aim to obtain micro-systems for cell encapsulation.
A phase 1, randomized, double-blind, placebo-controlled trial investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics of KN056 (a recombinant human GLP-1 variant Fc fusion protein) in healthy Chinese participants
Creators: name: Qin, Yuan-Fang
name: Zhang, Wen-Hua
name: Zhang, Hao-Nan
name: Li, Yu-Wei
name: Huang, Wen-Qiao
name: Xie, Jin-Lian
name: Yang, Shuang
name: Li, Lan-Ni
name: Cui, Chang
name: Pei, Qi
name: Huang, Jie
name: Yang, Guo-Ping
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Virology

description: This randomized clinical pharmacology trial investigated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of KN056 following single-dose subcutaneous administration in healthy Chinese participants. Thirty healthy male subjects were randomized to receive a single dose of KN056 (0.5, 1.0, 3.0, 6.0, or 12.0 mg) or placebo. PK and PD parameters, as well as safety and tolerability, were assessed. KN056 exposure increased proportionally with dose, with a half-life ranging from 141 to 188 hours. KN056 was well-tolerated, with gastrointestinal adverse events being the most common, particularly at the highest dose (12.0 mg). In the oral glucose tolerance test, KN056 dose-dependently decreased the AUC on the glucose versus time (gAUC) from baseline within 144 hours post-dosing. Specifically, the maximum reduction was 29.9% (occurring at the 72-hour mark). Body weight decreased within seven days of administration, correlating with dose levels, with a mean reduction of −1.68 kg in the 12.0 mg group; however, no significant change in body weight was observed by the end of the study. KN056 demonstrated favorable PK, PD, and safety profiles in healthy Chinese participants, supporting its potential for once-weekly dosing.
title: Effects on Piping Plover (Charadrius melodus Ord) Foraging Habitat from Sea-Level Rise: A Geographic Information Systems Approach
Creators: name: Lostritto, Peter
Publisher: name: George Mason University
Year: 2013
Subjects: subject: Piping plover
subject: Geographic Information Systems (GIS)
subject: Sea-level rise
subject: Suitable habitat
subject: Wetlands
subject: Charadrius melodus

description: Sea-level rise from global climate change is becoming increasingly important especially in geographic sciences, where space and time are taken into account. Globally, the mid- Atlantic shoreline of the United States is expected to be at greater risk than the observed global sea-level rise due to localized sinking of the land surface. The shorebird species Piping Plover (Charadrius melodus), an endangered species, is predicted to be particularly at risk from the estimated rising sea levels due to their already vulnerable breeding habitat within their distribution along the United States Atlantic coast. Traditionally, research has examined the threats to C. melodus nesting habitats; however, one of their most important foraging habitats, coastal wetlands, which is often depended upon by recently hatched chicks, is preferentially at risk from future rising sea levels. This study investigates how wetlands within C. melodus predicted suitable habitat may be affected from rising sea levels for up to 120 years into the future (from 2006). The specific objectives are threefold: (i) parameterize a functional habitat suitability model for C. melodus; (ii) evaluate the accuracy of the habitat suitability model in field sites; and (iii) investigate the prospective effects of sea-level rise on wetlands within the predicted suitable habitat of C. melodus at time intervals of 30, 60, and 120 years. Geographic Information Systems (GIS) were used as a tool to predict future outcomes to C. melodus wetlands foraging habitat from sea-level rise. Maps for three different locations within Piping Plover breeding distribution (Cape May, Assateague NWR, and Chincoteague NWR) were created showing outcomes for several sea-level rise scenarios. Results indicate that effects from sea-level rise on C. melodus wetlands habitat vary based on location. Two of the locations (Assateague NWR and Chincoteague NWR), which are barrier islands, are predicted to be negatively affected from sea-level rise (73- 94% net loss for Assateague NWR and 48-90% net loss for Chincoteague NWR in 120 years), whereas the Cape May location, which is not a barrier island, is predicted to have little to no negative impact from sea-level rise on the wetlands within Piping Plover predicted suitable habitat. From these investigations of three locations in the mid- Atlantic region, it is concluded that the effect of sea level rise in the future on wetlands foraging habitat for C. melodus is site specific, with two of the three locations exhibiting significant losses (48-94%) in habitat within 120 years. Given that this species is already endangered, this conclusion indicates that future changes in sea level will place an additional stress on the species.
Supplementary document for Single Frame Laser Diode Photoacoustic Imaging: Denoising and Reconstruction - 6346943.pdf
Creators: name: Vousten, Vincent
name: Moradi, Hamid
name: Boctor, Emad
name: Salcudean, Tim
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document with additional figures.
Supramolecular Photoresponsive Systems
Creators: name: Ferrito, Maria Stefania <1986>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2016
Subjects: CHIM/06 Chimica organica

description: This PhD research project deals with the synthesis and characterization of supramolecular photoresponsive systems based on the azobenzene unit.
1)Azobenzene-cyclodextrin inclusion complexes: the aim of this study was to obtain relatively simple, water-soluble derivatives, whose self-assembly could be reversibly controlled by light. On the basis of previous results, this opens the possibility of directly converting light into mechanical energy via osmosis. Several
new azobenzene functionalized cyclodextrins have been synthesized, fully characterized and studied The inclusion
complexes thus formed and their light-driven disassembly were studied by means of several
complementary techniques including NMR, UV, CD, ICT, mass spectroscopy. The most suitable
systems were used in experiments, still in progress, of light-to-mechanical energy conversion. 
2)Azobenzene-guanosine hybrids: several novel azobenzene-guanosine hybrids were synthesized for the purpose of investigating the effect of cis-trans photoisomerization on guanosine self-assembly. Lipophilic guanosines in organic solvents can form either ribbon-like supramolecular polymers or, in the presence of alkali metal ions, G-quartet
based supramolecular complexes. These complexes were fully characterized for newly synthesized
azobenzene-guanosine hybrids. In the absence of ions, the ribbon-like supramolecular polymer
gives rise to a gel-like system, which turned out to be a lyotropic liquid
crystalline phase. Photoisomerization to cis form induces the transition to an isotropic solution,
in a reversible fashion. In addition, the G-quartet structure obtained in the presence of alkali metal
ions can be disassembled by light. 
3) Oligoazobenzenes’s project. While several examples of electron-rich conjugated polymers are
known and find application e.g. as electron donors in “plastic” photovoltaics, no examples are
reported on the use of electron-poor conjugated polymers as acceptor counterpart. In particular, no
polyazobenzenes having the (-C6H4-N=N-) repeat unit have ever been reported. Although no
polymeric has been obtained yet, we succeeded in synthesizing several homologues up to a
tetramer. The compounds were subjected to photophysical, photochemical and electrochemical
characterization.
Tales of fire and flood : divine destruction stories in ancient Mesopotamia and the Pentateuch
Creators: name: Woods, Jonathan
Publisher: name: The University of St Andrews
Year: 2023
Subjects: subject: Pentateuch
subject: Divine destruction
subject: Intertextuality
subject: Divine Justice
subject: BS1225.52W7
subject: Bible. Pentateuch--Criticism, interpretation, etc.

description: This thesis examines the motif of divine destruction within ancient Mesopotamia and the Pentateuch. Yhwh attempts to destroy an entire community on eight occasions within the Pentateuch. Scholarship has predominantly read these stories as isolated incidents. This thesis asks whether a more intricate connection exists between the Pentateuchal divine destruction stories. And if such a connection exists, does this provide greater insight into the purpose of these destruction stories for the community who wrote and read them? In addition, this thesis examines the uniqueness of Hebrew divine destruction texts within the ancient Near Eastern context. A synchronic approach is used to analyse these texts in their final form. However, the revision of texts because of their engagement with other texts during the redactional process is an important premise of this project’s approach. It provides the basis for an analysis of intertextuality between stories of divine destruction. This thesis identifies a close intertextual relationship between the Flood, Sodom, Reed Sea, and Golden Calf stories. The development of theological ideas occurs as the narrative moves from a passive acceptance of destruction in Genesis 6-9 to the prevention of destruction in Exodus 32-34. An intertextual relationship is also identified between the rebellion stories of Numbers and Exod 32-34. These rebellions affirm, modify, and place limitations on the theological ideas developed in the Genesis and Exodus destruction stories. Finally, the Hebrew destruction stories share elements with destruction texts from ancient Mesopotamia. However, in many key aspects they are unique within their context. The theological sophistication and contextual uniqueness of the Pentateuchal destruction texts make them essential to understanding how the writers of the Hebrew Bible conceived of the relationship between God and humanity.
title: Annals of Social and Behavioural Sciences , Vol. 4 No. 1 (2022): Annals of Social and Behavioural Sciences Journal
title: Annals of Social and Behavioural Sciences Journal
titleType: AlternativeTitle
Creators: name: Annals Of Social And Behavioural Sciences
Publisher: name: Annals of Social and Behavioural Sciences
Year: 2022

description: The Annals of Social and Behavioural Sciences Journal (ASBSJ) is an interdisciplinary journal whose principal goal is to publish insightful and game-changing scholarly work in the social and behavioural sciences. The Journal welcomes scholarly manuscripts that address, but are not limited to the following disciplines of social and behavioural sciences, along with their subdisciplines:
1. Art and Design
2. Business Sciences
3. Culture and Heritage
4. Development Studies
5. Natural Resources Conservation
6. Social Ecology
7. Tourism and Hospitality, and any other related areas
8. Health Sciences and Technology
description: Annals of Social and Behavioural Sciences Issue 4 (1), 2022
Packaging natural springs into community hubs for wellness and spa tourism
The challenges of adopting afforestation as an alternative and sustainable land use for economic development
A review of performance management systems in higher education institutions across the globe
Re-thinking ecotourism and community development
Commercial agriculture finance in Zimbabwe
Commercial agriculture finance in Zimbabwe
Editorial comment
Annotated Bibliography from A restatement of the natural science evidence base regarding the source, spread and control of Campylobacter species causing human disease
Creators: name: Goddard, Matthew R.
name: O'Brien, Sarah
name: Williams, Nicola
name: Guitian, Javier
name: Grant, Andrew
name: Cody, Alison
name: Colles, Frances
name: Buffet, Jean-Charles
name: Adlen, Ella
name: Stephens, Andrea
name: Godfray, H. Charles J.
name: Maiden, Martin C. J.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: The sources of evidence for each statement are provided along with author notes where appropriate
Supplementary document for Coupled Mode Theory Revisited: The role of the1 Network’s Topology and Ordered Directionality - 6347008.pdf
Creators: name: de Rezende, Guilherme
name: Frateschi, Newton
name: de Castro Carvalho, Cauê Moreno Kersul
name: Barea, Luis
name: da Ascenção, Gabriel Rezende
name: Assis, Pierre
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: From TMM to CMT with Matrix Reduction and Graph Theory
title: Influence of Cell Cycle Alteration on Venezuelan Equine Encephalitis Virus
Creators: name: Fontenot, Jacque L
Publisher: name: George Mason University
Year: 2014
Subjects: subject: Venezuelan Equine Encephalitis virus
subject: Cell cycle
subject: Capsid
subject: Cyclin

description: Venezuelan Equine Encephalitis Virus (VEEV), of the Togaviridae family and Alphavirus genus, is the causative agent of potentially fatal viral encephalitis. The virus is transmitted to humans via the bite of infected Culex mosquitoes that have fed on infected equines. VEEV is an emerging pathogen and with no tangible large scale vaccine available, has the potential to cause epidemics. The virally encoded capsid protein is responsible for causing cytopathic effect at least partially due to inducing a transcriptional shutoff in infected cells. A nuclear localization sequence within the capsid protein allows nuclear import of capsid and blocking of the nuclear pores thereby inhibiting the import and export of cellular proteins. Other nuclear localized viral proteins are known to induce alterations of the cell cycle in order to create favorable conditions for viral replication. Understanding how VEEV manipulates the cell cycle will provide possible intracellular targets for future antiviral strategies. In this study we show that VEEV infected cells have a delayed cell cycle progression following serum starvation. Western blot analysis showed decreased Cyclin E and A2 levels at 16 and 24 hours post infection (hpi). Phosphorylation of Rb remained low at 16 and 24hpi in infected cells, further confirming the cell cycle delay in infected cells. UV inactivated VEEV did not induce this delay in return to cell cycle, indicating that replication competent VEEV is needed for the induction of this delay. Cdk4/6 and Cdk1 inhibitor treated cells showed significant decreases in VEEV replication. Hydroxyurea, nocodazole and thymidine synchronized cells showed significant decreases in viral replication as well. The results of our study show that VEEV is delaying the cell cycle progression of synchronized cells and that VEEV needs an actively replicating population of cells for optimal viral replication kinetics. Future studies will focus on confirming that capsid’s nuclear localization is responsible for these observations through the use of a capsid NLS mutant virus.
title: OIS Center Honorar-Richtwerte
title: OIS Center Honorarium Guidelines
titleType: AlternativeTitle
Creators: name: Grill, Christiane
name: Thomas, Palfinger
Publisher: name: Zenodo
Year: 2022
Subjects: PPIE
Honorarguidelines
OIS

description: Die aktive Einbindung von Bürger:innen, Betroffenen und Interessensgruppen in die Forschung kann vielfältig erfolgen – von beratender Mitwirkung in Advisory Boards bis hin zur gemeinsamen Datenerhebung und Dissemination. Dieser Leitfaden skizziert verschiedene Partizipationsmöglichkeiten und betont die Bedeutung einer angemessenen Wertschätzung. Das LBG OIS Center empfiehlt, eingebundene Personen durch Honorare oder alternative Vergütungsformen zu entschädigen und dabei transparente Kommunikation sicherzustellen. Zudem werden Möglichkeiten zur Rückerstattung von Aufwänden wie Reise- und Verpflegungskosten thematisiert.
description: The active involvement of citizens, affected individuals, and stakeholder groups in research can take many forms – from advisory roles in boards to co-developing research questions, collecting and analyzing data, and disseminating results. This guide outlines various participation opportunities and highlights the importance of appropriate recognition. The LBG OIS Center recommends compensating engaged individuals through honoraria or alternative remuneration methods while ensuring transparent communication. Additionally, options for reimbursing expenses such as travel and meals are discussed.
title: The Curious Case of the White-Tailed Deer: An Analysis of Deer Use in the Ceremonial Center of Teotihuacan
Creators: name: Aguayo, Esther
Publisher: name: George Mason University
Year: 2021
Subjects: subject: Mesoamerica
subject: Deer
subject: Archaeology
subject: White-tailed deer
subject: Teotihuacan
subject: Zooarchaeology

description: This thesis investigates the pattern of deer bones present at the Plaza of the Columns Complex in the ceremonial center of the ancient metropolis, Teotihuacan. As a large urban center, with a population of around 100,000 people at its height, Teotihuacan had to have a complex food system in order to feed its population. Interestingly, the largest mammal available in the New World, the white-tailed deer (Odocoileus virginianus), is a rare animal in Teotihuacan’s faunal assemblage. This research, which involves the study of deer remains, indicated that deer were not a necessary resource in the everyday life of Teotihuacanos. Instead, deer exploitation was elevated into highly specific ritual contexts, such as offerings and consumed by elite groups that partook in such occasions.
title: Sketch of the second battle of Manassas, August 30th 1862
Creators: name: Unknown
Publisher: name: George Mason University
Year: 2011
Subjects: subject: Virginia
subject: Manassas, 2nd Battle of, Va., 1862

description: Public domain. There are no known use restrictions.
description: Undated sketch of the second battle of Manassas, August 30th 1862