Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Creators: name: Lagou, Vasiliki
name: Mägi, Reedik
name: Hottenga, Jouke- Jan
name: Grallert, Harald
name: Perry, John R. B.
name: Bouatia-Naji, Nabila
name: Marullo, Letizia
name: Rybin, Denis
name: Jansen, Rick
name: Min, Josine L.
name: Dimas, Antigone S.
name: Ulrich, Anna
name: Zudina, Liudmila
name: Gådin, Jesper R.
name: Jiang, Longda
name: Faggian, Alessia
name: Bonnefond, Amélie
name: Fadista, Joao
name: Stathopoulou, Maria G.
name: Isaacs, Aaron
name: Willems, Sara M.
name: Navarro, Pau
name: Tanaka, Toshiko
name: Jackson, Anne U.
name: Montasser, May E.
name: O’Connell, Jeff R.
name: Bielak, Lawrence F.
name: Webster, Rebecca J.
name: Saxena, Richa
name: Stafford, Jeanette M.
name: Pourcain, Beate St
name: Timpson, Nicholas J.
name: Salo, Perttu
name: Shin, So-Youn
name: Amin, Najaf
name: Smith, Albert V.
name: Li, Guo
name: Verweij, Niek
name: Goel, Anuj
name: Ford, Ian
name: Johnson, Paul C. D.
name: Johnson, Toby
name: Kapur, Karen
name: Thorleifsson, Gudmar
name: Strawbridge, Rona J.
name: Rasmussen-Torvik, Laura J.
name: Esko, Tõnu
name: Mihailov, Evelin
name: Fall, Tove
name: Fraser, Ross M.
name: Mahajan, Anubha
name: Kanoni, Stavroula
name: Giedraitis, Vilmantas
name: Kleber, Marcus E.
name: Silbernagel, Günther
name: Meyer, Julia
name: Müller-Nurasyid, Martina
name: Ganna, Andrea
name: Sarin, Antti-Pekka
name: Yengo, Loic
name: Shungin, Dmitry
name: Luan, Jian’an
name: Horikoshi, Momoko
name: An, Ping
name: Sanna, Serena
name: Boettcher, Yvonne
name: Rayner, N. William
name: Nolte, Ilja M.
name: Zemunik, Tatijana
name: Iperen, Erik Van
name: Kovacs, Peter
name: Hastie, Nicholas D.
name: Wild, Sarah H.
name: McLachlan, Stela
name: Campbell, Susan
name: Polasek, Ozren
name: Carlson, Olga
name: Egan, Josephine
name: Kiess, Wieland
name: Willemsen, Gonneke
name: Kuusisto, Johanna
name: Laakso, Markku
name: Dimitriou, Maria
name: Hicks, Andrew A.
name: Rauramaa, Rainer
name: Bandinelli, Stefania
name: Thorand, Barbara
name: Liu, Yongmei
name: Miljkovic, Iva
name: Lind, Lars
name: Doney, Alex
name: Perola, Markus
name: Hingorani, Aroon
name: Kivimaki, Mika
name: Kumari, Meena
name: Bennett, Amanda J.
name: Groves, Christopher J.
name: Herder, Christian
name: Koistinen, Heikki A.
name: Kinnunen, Leena
name: Faire, Ulf De
name: Bakker, Stephan J. L.
name: Uusitupa, Matti
name: Palmer, Colin N. A.
name: Jukema, J. Wouter
name: Sattar, Naveed
name: Pouta, Anneli
name: Snieder, Harold
name: Boerwinkle, Eric
name: Pankow, James S.
name: Magnusson, Patrik K.
name: Krus, Ulrika
name: Scapoli, Chiara
name: De Geus, Eco J. C. N.
name: Blüher, Matthias
name: Wolffenbuttel, Bruce H. R.
name: Province, Michael A.
name: Abecasis, Goncalo R.
name: Meigs, James B.
name: Hovingh, G. Kees
name: Lindström, Jaana
name: Wilson, James F.
name: Wright, Alan F.
name: Dedoussis, George V.
name: Bornstein, Stefan R.
name: Schwarz, Peter E. H.
name: Tönjes, Anke
name: Winkelmann, Bernhard R.
name: Boehm, Bernhard O.
name: März, Winfried
name: Metspalu, Andres
name: Price, Jackie F.
name: Deloukas, Panos
name: Körner, Antje
name: Lakka, Timo A.
name: Keinanen-Kiukaanniemi, Sirkka M.
name: Saaristo, Timo E.
name: Bergman, Richard N.
name: Tuomilehto, Jaakko
name: Wareham, Nicholas J.
name: Langenberg, Claudia
name: Männistö, Satu
name: Franks, Paul W.
name: Hayward, Caroline
name: Vitart, Veronique
name: Kaprio, Jaakko
name: Visvikis-Siest, Sophie
name: Balkau, Beverley
name: Altshuler, David
name: Rudan, Igor
name: Stumvoll, Michael
name: Campbell, Harry
name: Van Duijn, Cornelia M.
name: Gieger, Christian
name: Illig, Thomas
name: Ferrucci, Luigi
name: Pedersen, Nancy L.
name: Pramstaller, Peter P.
name: Boehnke, Michael
name: Frayling, Timothy M.
name: Shuldiner, Alan R.
name: Peyser, Patricia A.
name: Kardia, Sharon L. R.
name: Palmer, Lyle J.
name: Penninx, Brenda W.
name: Meneton, Pierre
name: Harris, Tamara B.
name: Navis, Gerjan
name: Harst, Pim Van Der
name: Smith, George Davey
name: Forouhi, Nita G.
name: Loos, Ruth J. F.
name: Salomaa, Veikko
name: Soranzo, Nicole
name: Boomsma, Dorret I.
name: Groop, Leif
name: Tuomi, Tiinamaija
name: Hofman, Albert
name: Munroe, Patricia B.
name: Gudnason, Vilmundur
name: Siscovick, David S.
name: Watkins, Hugh
name: Lecoeur, Cecile
name: Vollenweider, Peter
name: Franco-Cereceda, Anders
name: Eriksson, Per
name: Jarvelin, Marjo-Riitta
name: Stefansson, Kari
name: Hamsten, Anders
name: Nicholson, George
name: Karpe, Fredrik
name: Dermitzakis, Emmanouil T.
name: Lindgren, Cecilia M.
name: McCarthy, Mark I.
name: Froguel, Philippe
name: Kaakinen, Marika A.
name: Lyssenko, Valeriya
name: Watanabe, Richard M.
name: Ingelsson, Erik
name: Florez, Jose C.
name: Dupuis, Josée
name: Barroso, Inês
name: Morris, Andrew P.
name: Prokopenko, Inga
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/208/205/2138
/631/208/480
/692/53/2421
/692/699/2743/2815
/692/163/2743/137/773
/45/43
article

description: Funder: EU H2020
description: Abstract: Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.