cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Theologien des Priesteramts und ihr möglicher Einfluss auf sexuellen Kindesmissbrauch
Creators: name: Conway, Eamonn
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 3 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 3
From The Cover: Increased salinization of fresh water in the northeastern United States
Creators: name: Kaushal, S. S.
name: Stack, W. P.
name: Fisher, G. T.
name: Likens, G. E.
name: Kelly, V. R.
name: Belt, K. T.
name: Band, L. E.
name: Groffman, P. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Chloride concentrations are increasing at a rate that threatens the availability of fresh water in the northeastern United States. Increases in roadways and deicer use are now salinizing fresh waters, degrading habitat for aquatic organisms, and impacting large supplies of drinking water for humans throughout the region. We observed chloride concentrations of up to 25% of the concentration of seawater in streams of Maryland, New York, and New Hampshire during winters, and chloride concentrations remaining up to 100 times greater than unimpacted forest streams during summers. Mean annual chloride concentration increased as a function of impervious surface and exceeded tolerance for freshwater life in suburban and urban watersheds. Our analysis shows that if salinity were to continue to increase at its present rate due to changes in impervious surface coverage and current management practices, many surface waters in the northeastern United States would not be potable for human consumption and would become toxic to freshwater life within the next century.
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2
Creators: name: Griffin, C. T.
name: Trejo, J.
name: Magnuson, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We have previously shown that the putative mammalian retromer components sorting nexins 1 and 2 (Snx1 and Snx2) result in embryonic lethality when simultaneously targeted for deletion in mice, whereas others have shown that Hβ58 (also known as mVps26), another retromer component, results in similar lethality when targeted for deletion. In the current study, we address the genetic interaction of these mammalian retromer components in mice. Our findings reveal a functional interaction between Hβ58, SNX1, and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 in retromer activity during embryonic development. This genetic evidence supports the existence of mammalian retromer complexes containing SNX1 and SNX2 and identifies SNX2 as an important mediator of retromer biology. Moreover, we find that mammalian retromer complexes containing SNX1 and SNX2 have an essential role in embryonic development that is independent of cation-independent mannose 6-phosphate receptor trafficking.
Angiostoma meets Phasmarhabditis: a case of Angiostoma kimmeriense Korol & Spiridonov, 1991
Creators: name: Ivanova, Elena S.
name: Spiridonov, Sergei E.
Publisher: name: Russian Journal of Nematology
Year: 2018
Subjects: description
D2-D3 LSU sequences
ITS RNA sequences
Mollusca
morphology
morphometrics
phylogeny
taxonomy

description: Angiostoma kimmeriense (= A. kimmeriensis) Korol & Spiridonov, 1991 was re-isolated from the snail Oxyhilus sp. in the West Caucasus (Adygea Republic) and characterised morphologically and molecularly. The morphology of the genus Angiostoma Dujardin, 1845 was discussed and vertebrateassociated species suggested to be considered as species insertae sedis based on the head end structure (3 vs 6 lips). Phylogenetic analysis based on partial sequences of three RNA domains (D2-D3 segment of LSU rDNA and ITS rDNA) did not resolve the relationships of A. kimmeriense, as the most similar sequences of these loci were found between members of another gastropod associated genus, Phasmarhabditis Andrássy, 1976. However, such biological traits of A. kimmeriense as its large size, limited number of parasites within the host and the site of infection, point to a parasitic rather than pathogenic/necromenic way of life typical for Phasmarhabditis.
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
Creators: name: Fischer, L. M.
name: da Costa, K.-A.
name: Kohlmeier, M.
name: Zeisel, S. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some of the dietary requirement and requires one-carbon groups derived from folate metabolism. We examined whether major genetic variants of folate metabolism modify susceptibility of humans to choline deficiency. Fifty-four adult men and women were fed diets containing adequate choline and folate, followed by a diet containing almost no choline, with or without added folate, until they were clinically judged to be choline-deficient, or for up to 42 days. Criteria for clinical choline deficiency were a more than five times increase in serum creatine kinase activity or a >28% increase of liver fat after consuming the low-choline diet that resolved when choline was returned to the diet. Choline deficiency was observed in more than half of the participants, usually within less than a month. Individuals who were carriers of the very common 5,10-methylenetetrahydrofolate dehydrogenase-1958A gene allele were more likely than noncarriers to develop signs of choline deficiency (odds ratio, 7.0; 95% confidence interval, 2.0-25; P < 0.01) on the low-choline diet unless they were also treated with a folic acid supplement. The effects of the C677T and A1298C polymorphisms of the 5,10-methylene tetrahydrofolate reductase gene and the A80C polymorphism of the reduced folate carrier 1 gene were not statistically significant. The most remarkable finding was the strong association in premenopausal women of the 5,10-methylenetetrahydrofolate dehydrogenase-1958A gene allele polymorphism with 15 times increased susceptibility to developing organ dysfunction on a low-choline diet.
Faceting Oscillations in Nano-Ferroelectrics
Creators: name: Scott, J. F.
name: Kumar, Ashok
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We observe periodic faceting of 8-nm diameter ferroelectric disks on a 10 s time-scale when thin Pb(Zr0.52Ti0.48)O3 (PZT) film is exposed to constant high-resolution transmission electron microscopy (HRTEM) beams. The oscillation is between circular disk geometry and sharply faceted hexagons. The behavior is analogous to that of spin structure and magnetic domain wall velocity oscillations in permalloy [A. Bisig et al., Nature Commun. 4, 2328 (2013)], involving overshoot and de-pinning from defects [C. P. Amann, et al., J. Rheol. 57, 149-175 (2013)].
description: 14 pages, 3 figures
The complexity of food for people with multiple long-term health conditions
Creators: name: Francis, Helen
name: Carryer, Jenny
name: Wilkinson, Jillian
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified

description: ABSTRACT INTRODUCTION The prevalence of long-term health conditions (LTCs) continues to increase and it is normal for people to have several. Lifestyle is a core feature of the self-management support given to people with LTCs, yet it seems to fail to meet their needs. From a larger study exploring the experiences of this group, this paper reports on the role of food and mealtimes, and the effect of the nutritional advice on the lives of people with several LTCs. METHODS The experiences of 16 people with several advanced LTCs were explored using multiple qualitative case studies. Over an 18-month period, contact with participants included monthly conversations, two longer, semi-structured interviews and one interview with their primary care clinicians. The data were analysed inductively using thematic analysis. RESULTS There was profound social, psychological and cultural significance of food to the participants. These aspects of food were then described using the Whare Tapa Wha model of health. The approach to food and nutrition participants experienced in health care was closely associated with conventional weight management. They found this advice largely irrelevant and therefore ineffective. DISCUSSION The pressure people with several LTCs experience during clinical encounters has perverse effects on wellbeing and reinforces an overall sense of failure. This research challenges the assumption that all people have the will, agency and income to follow the advice they receive about nutrition and exercise. Considering people’s needs using the Whare Tapa Wha model of health offers clinicians a framework to re-conceptualise the core features of self-management support and provide realistic, compassionate care that will optimise the quality of life for people with multiple LTCs.
From rally to reality: unveiling long-term dynamics in political trust over two years of COVID-19 in Germany
Creators: name: Zoch, Gundula
name: Wamsler, Steffen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Crises like wars, terrorist attacks, and economic or health crises are frequently followed by profound changes in political trust. Whereas immediate external threats often induce a strong initial increase in political trust, the ‘rally-around-the-flag’ effect, prolonged crises are more detrimental to this core feature of political support. We extend previous research on political trust during extended crises by using the case of the global Covid-19 pandemic. Employing individual-level panel data from Germany (N = 21,001, 2017–2022) and district-level data on infection rates and government-imposed restrictions, we distinguish time trends from both government action and crisis severity for various government and non-government actors such as media or corporations. Results from fixed-effects regression models reveal a prolonged increase in individual-level political trust throughout 2020 and early 2021, followed by a significant decline in 2021/22. Contrary to extant work, we find limited influence of infection rates, whereas more stringent government policies explain decreasing trust later in the pandemic. These results are robust to including individual-level pandemic experiences like changes in work and family life. Thus, our results provide first evidence on the longevity of the initial rally effect in a high-trust country, which remains discernible at least one year into the pandemic.
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
Creators: name: Varga, R.
name: Fiordalisi, J. J.
name: Capell, B. C.
name: Der, C. J.
name: Erdos, M. R.
name: Cox, A. D.
name: Conneely, K. N.
name: Gordon, L. B.
name: Collins, F. S.
name: Madigan, J. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is characterized by dramatic premature aging and accelerated cardiovascular disease. HGPS is almost always caused by a de novo point mutation in the lamin A gene (LMNA) that activates a cryptic splice donor site, producing a truncated mutant protein termed “progerin.” WT prelamin A is anchored to the nuclear envelope by a farnesyl isoprenoid lipid. Cleavage of the terminal 15 aa and the farnesyl group releases mature lamin A from this tether. In contrast, this cleavage site is deleted in progerin. We hypothesized that retention of the farnesyl group causes progerin to become permanently anchored in the nuclear membrane, disrupting proper nuclear scaffolding and causing the characteristic nuclear blebbing seen in HGPS cells. Also, we hypothesized that blocking farnesylation would decrease progerin toxicity. To test this hypothesis, the terminal CSIM sequence in progerin was mutated to SSIM, a sequence that cannot be farnesylated. SSIM progerin relocalized from the nuclear periphery into nucleoplasmic aggregates and produced no nuclear blebbing. Also, blocking farnesylation of authentic progerin in transiently transfected HeLa, HEK 293, and NIH 3T3 cells with farnesyltransferase inhibitors (FTIs) restored normal nuclear architecture. Last, treatment of both early- and late-passage human HGPS fibroblasts with FTIs resulted in significant reductions in nuclear blebbing. Our results suggest that treatment with FTIs represents a potential therapy for patients with HGPS.
Sexuelle Gewalt gegen Kinder - eine Verletzung des christlich begründeten Kinderschutzes
Creators: name: Lutterbach, Hubertus
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 3 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 3
Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN- -inducible MHC-II gene expression
Creators: name: Fauquier, L.
name: Vandel, L.
name: Zika, E.
name: Ting, J. P.-Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Class II major histocompatibility (MHC-II) genes are prototype targets of IFN-γ. IFN-γ activates the expression of the non-DNA-binding master regulator of MHC-II, class II transactivator (CIITA), which is crucial for enhanceosome formation and gene activation. This report shows the importance of the histone methyltransferase, coactivator-associated arginine methyltransferase (CARM1/PRMT4), during IFN-γ-induced MHC-II gene activation. It also demonstrates the coordinated regulation of CIITA, CARM1, and the acetyltransferase cyclic-AMP response element binding (CREB)-binding protein (CBP) during this process. CARM1 synergizes with CIITA in activating MHC-II transcription and synergy is abrogated when an arginine methyltransferase-defective CARM1 mutant is used. Protein-arginine methyltransferase 1 has much less effect on MHC-II transcription. Specific RNA interference reduced CARM1 expression as well as MHC-II expression. The recruitment of CARM1 to the promoter requires endogenous CIITA and results in methylation of histone H3-R17; hence, CIITA is an upstream regulator of histone methylation. Previous work has shown that CARM1 can methylate CBP at three arginine residues. Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-γ induction of MHC-II. A kinetic analysis shows that CIITA, CARM1, and H3-R17 methylation all precede CBP loading on the MHC-II promoter during IFN-γ treatment. These results suggest functional and temporal relationships among CIITA, CARM1, and CBP for IFN-γ induction of MHC-II.
Morphological and molecular characterisation of anisakid juveniles from the golden grey mullet of the Black Sea
Creators: name: Pronkina, Natalia V.
name: Spiridonov, Sergei E.
Publisher: name: Russian Journal of Nematology
Year: 2018
Subjects: Contracaecum
Chelon auratus
IST rDNA
juvenile stages
LSU rDNA
marine fish
phylogeny

description: The anisakid juveniles of the genus Contracaecum were regularly reported from liver ducts of the golden grey mullet Chelon auratus (Risso, 1810) collected in the Black Sea coastal waters of Crimean peninsula. Primarily, these juveniles were identified as C. rudolphii (spiculigerum) Hartwich, 1964. After additional morphological study and analysis of nucleotide sequences the juveniles were identified as Contracaecum multipapillatum (Drasche, 1882) Lucker, 1941. Phylogenetic analysis revealed, that partial sequence of LSU rDNA of Contracaecum juveniles from golden grey mullet is identical to the deposited LSU rDNA sequence (AF226574) of C. multipapillatum from pelicans in Greece. According to the analysis of ITS rDNA this sequence of C. multipapillatum from the Black Sea is similar to those of C. multipapillatum from Australian pelicans.
Isolating gene-corrected stem cells without drug selection
Creators: name: Ciavatta, D.
name: Smithies, O.
name: Cowhig, J. E.
name: Hatada, T.
name: Hatada, S.
name: Arnold, L. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Progress in isolating stem cells from tissues, or generating them from adult cells by nuclear transfer, encourages attempts to use stem cells from affected individuals for gene correction and autologous therapy. Current viral vectors are efficient at introducing transgenic sequences but result in random integrations. Gene targeting, in contrast, can directly correct an affected gene, or incorporate corrective sequences into a site free from undesirable side effects, but efficiency is low. Most current targeting procedures, consequently, use positive-negative selection with drugs, often requiring ≥10 days. This drug selection causes problems with stem cells that differentiate in this time or require feeder cells, because the feeders must be drug resistant and so are not eliminated by the selection. To overcome these problems, we have developed a procedure for isolating gene-corrected stem cells free from feeder cells after 3-5 days culture without drugs. The method is still positive-negative, but the positive and negative drug-resistance genes are replaced with differently colored fluorescence genes. Gene-corrected cells are isolated by FACS. We tested the method with mouse ES cells having a mutant hypoxanthine phosphoribosyltransferase (Hprt) gene and grown on feeder cells. After 5 days in culture, gene-corrected cells were obtained free from feeder cells at a “purity” of >30%, enriched >2,000-fold and with a recovery of ≈20%. Corrected cells were also isolated singly for clonal expansion. Our FACS-based procedure should be applicable at small or large scale to stem cells that can be cultured (with feeder cells, if necessary) for ≥3 days.
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
Creators: name: Damania, B.
name: Cullen, B. R.
name: Gonzalez, C. M.
name: Cai, X.
name: Zhang, Z.
name: Lu, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: MicroRNAs (miRNAs) are an endogenously encoded class of small RNAs that have been proposed to function as key posttranscriptional regulators of gene expression in a range of eukaryotic species, including humans. The small size of miRNA precursors makes them potentially ideal for use by viruses as inhibitors of host cell defense pathways. Here, we demonstrate that the pathogenic human herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) encodes an array of 11 distinct miRNAs, all of which are expressed at readily detectable levels in latently KSHV infected cells. Individual KSHV miRNAs were expressed at up to 2,200 copies per cell. The KSHV miRNAs are expressed from what appears to be a single genetic locus that largely coincides with an ≈4-kb noncoding sequence located between the KSHV v-cyclin and K12/Kaposin genes, both of which are also expressed in latently infected cells. Computer analysis of potential mRNA targets for these viral miRNAs identified a number of interesting candidate genes, including several mRNAs previously shown to be down-regulated in KSHV-infected cells. We hypothesize that these viral miRNAs play a critical role in the establishment and/or maintenance of KSHV latent infection in vivo and, hence, in KSHV-induced oncogenesis.
New polyketides and cytotoxic alkaloids from the mangrove endophytic fungus Talaromyces sp. SAF14
Creators: name: Li, Hong
name: Lin, Cankai
name: Chen, Kaixin
name: Zhou, Zhihui
name: Chen, Zanhong
name: Ding, Bo
name: Huang, Hongbo
name: Tao, Yiwen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Investigation of secondary metabolites from the mangrove endophytic fungus Talaromyces sp. SAF14 led to the isolation of two new polyketides, methyl (R)-3-(6,8-dihydroxy-7-methoxy-1-oxoisochroman-3-yl)propanoate (1), (R)-3-(5,8- dihydroxy-1-oxoisochroman-3-yl)propanoic acid (2), together with four known alkaloids (3–6). The planar structures of new compounds were elucidated by comprehensive analysis of HR-ESI-MS and NMR data. The absolute configurations were determined by comparison of the calculated ECD spectrum with the measured one. All the isolated compounds were tested for cytotoxic activities against three human cancer cell lines. The known beauvericin (3) exhibited strong cytotoxic activity against A549, MCF-7, and KB cell lines with IC50 values of 5.36 ± 2.49, 1.96 ± 1.09 and 4.46 ± 0.68 μM, respectively.
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c
Creators: name: Hughes, C. M.
name: McLean, G. W.
name: Kim, S. K.
name: Xiong, Y.
name: Gu, X.
name: Meyerson, M.
name: Rozenblatt-Rosen, O.
name: Karnik, S. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Menin, the product of the Men1 gene mutated in familial multiple endocrine neoplasia type 1 (MEN1), regulates transcription in differentiated cells. Menin associates with and modulates the histone methyltransferase activity of a nuclear protein complex to activate gene expression. However, menin-dependent histone methyltransferase activity in endocrine cells has not been demonstrated, and the mechanism of endocrine tumor suppression by menin remains unclear. Here, we show that menin-dependent histone methylation maintains the in vivo expression of cyclin-dependent kinase (CDK) inhibitors to prevent pancreatic islet tumors. In vivo expression of CDK inhibitors, including p27 and p18, and other cell cycle regulators is disrupted in mouse islet tumors lacking menin. Chromatin immunoprecipitation studies reveal that menin directly associates with regions of the p27 and p18 promoters and increases methylation of lysine 4 (Lys-4) in histone H3 associated with these promoters. Moreover, H3 Lys-4 methylation associated with p27 and p18 is reduced in islet tumors from Men1 mutant mice. Thus, H3 Lys-4 methylation is a crucial function of menin in islet tumor suppression. These studies suggest an epigenetic mechanism of tumor suppression: by promoting histone modifications, menin maintains transcription at multiple loci encoding cell cycle regulators essential for endocrine growth control.
Use of ultrasound attenuation spectroscopy to determine the size distribution of clay tactoids in aqueous suspensions
Creators: name: Ali, Samim
name: Bandyopadhyay, Ranjini
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The dispersion processes of aqueous samples of clay are studied using ultrasound attenuation spectroscopy. The attenuation spectra that are acquired in the frequency range $10-100$ MHz are used to determine the particle size distributions (PSDs) for different concentrations and ages of the clay suspensions. Our analysis, using equivalent spherical diameter (ESD) for circular discs under Stokes drag in samples of concentrations greater than 1.5\% w/v, shows that a substantial fraction of the aggregates in suspension are actually tactoids that are composed of more than one platelet. This is in contrast to the general belief that clay disperses into individual platelets in the concentration range where their suspensions exhibit glassy behavior. We conclude that the incomplete fragmentation of the clay tactoids arises from the rapid enhancement of the inter-tactoid Coulombic repulsion.
description: 21 pages, 6 figures
New polyketides and cytotoxic alkaloids from the mangrove endophytic fungus Talaromyces sp. SAF14
Creators: name: Li, Hong
name: Li, Cankai
name: Chen, Kaixin
name: Zhou, Zhihui
name: Chen, Zanhong
name: Ding, Bo
name: Huang, Hongbo
name: Tao, Yiwen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Investigation of secondary metabolites from the mangrove endophytic fungus Talaromyces sp. SAF14 led to the isolation of two new polyketides, methyl (R)-3-(6,8-dihydroxy-7-methoxy-1-oxoisochroman-3-yl)propanoate (1), (R)-3-(5,8- dihydroxy-1-oxoisochroman-3-yl)propanoic acid (2), together with four known alkaloids (3–6). The planar structures of new compounds were elucidated by comprehensive analysis of HR-ESI-MS and NMR data. The absolute configurations were determined by comparison of the calculated ECD spectrum with the measured one. All the isolated compounds were tested for cytotoxic activities against three human cancer cell lines. The known beauvericin (3) exhibited strong cytotoxic activity against A549, MCF-7, and KB cell lines with IC50 values of 5.36 ± 2.49, 1.96 ± 1.09 and 4.46 ± 0.68 μM, respectively.
Chowan-Pasquotank River Basins Study: Projections of Land Use and Soil Loss in the Chowan-Pasquotank River Basin
Creators: name: Ogg, Clayton
name: Heimlich, Ralph
name: Ogg, Clayton
name: Heimlich, Ralph
Publisher: name: Unknown
Year: 1978
Subjects: subject: Crop Production/Industries
subject: Environmental Economics and Policy
subject: Land Economics/Use
subject: Production Economics
subject: Productivity Analysis
subject: Research Methods/ Statistical Methods
subject: Model
subject: Linear Programming
subject: Demand
subject: Environment
subject: Conservation
subject: Yield
subject: Budget
subject: Productivity

description: This report presents land use and soil loss projections for the Chowan-Pasquotank River Basin and describes inputs to the linear programming model. Total production or demand for 1990 and 2020 is based upon past trends in regional production shares of national and export markets. Other model inputs include basin yields and soil losses on soil groupings and budgeted costs. The model is designed to analyze economic and environmental impacts of soil and water conservation plans for the Basin.
description: In cooperation with Virginia Water Control Board and the North Carolina Department of Natural and Economic Resources (Working materials prepared for use by cooperating agencies - not for publication.)
IDS Methods Festival Presentation on Data Management
Creators: name: Speed, Garrett
Publisher: name: Zenodo
Year: 2022
Subjects: data management
GIS
international development studies

description: The International Development Studies (IDS) program at Utrecht University had a "Methods Festival" for their master's students to learn new research skills. Garrett was asked to speak present on data management and GIS at the festival. The Word document included in this repository includes the folder structure created interactively with the students. It is an analogue of the students research topics, but not their actual research topics.
Der Faktor der ethnischen Zugehörigkeit beim sexuellen Kindesmissbrauch durch Angehörige des Klerus
Creators: name: West, Traci C.
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 3 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 3
Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors
Creators: name: Gerig, G.
name: Styner, M.
name: Jones, D. W.
name: Weinberger, D. R.
name: McClure, R. K.
name: Lieberman, J. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The structural variability of lateral ventricles is poorly understood notwithstanding that enlarged size has been identified as an unspecific marker for psychiatric illness, including schizophrenia. This paper explores the effects of heritability and genetic risk for schizophrenia reflected in ventricular size and structure. We examined ventricular size and shape in the MRI studies of monozygotic (MZ) twin pairs discordant for schizophrenia (DS), healthy MZ twin pairs, healthy dizygotic twin pairs, and healthy nonrelated subject pairs. Heritability and effect due to disease were analyzed in two tests. First, heritability was examined by ventricle similarity between pairs of co-twins. Results show that co-twin ventricle shape similarity decreases with decreasing genetic identity, an effect not seen in the volume analysis. Co-twin shape similarity of healthy MZ twins did not differ from DS MZ twins. Second, the disease effect was examined through the ventricular differences of DS subjects to a template shape representing healthy subjects. Affected DS twins showed shape differences from healthy subjects on the left and right sides. Interestingly, unaffected DS twins also showed significant shape differences from healthy subjects for both sides. Volume comparisons did not show differences between these groups. Locality of shape difference suggests that the ventricular shape of the anterior and posterior regions is under genetic influence in both healthy controls and schizophrenia patients. Affected and unaffected groups demonstrate main shape differences, compared with healthy controls, only in the posterior region. Our results suggest that genetics have a stronger influence on the shape of lateral ventricles than do the disease-related changes in schizophrenia.
Adoptee Activism: I Am Not Your ‘Child for All Purposes’
Creators: name: Blake, Denise
name: Ahuriri-Driscoll, Annabel
name: Sumner, Barbara
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: Closed adoption emerged in the mid-20th century as a socio-legal intervention to address ‘problems’ with the care of children, ex-nuptial births, and couples experiencing infertility. Governing adoption practices is the Adoption Act 1955, which is still in effect in Aotearoa New Zealand, despite a general consensus that it is out of step with contemporary thinking and social mores. As part of current efforts to reform this law, adult adoptees have taken up the challenge of speaking out about the effects of closed stranger adoption and what needs to change. This article explores three adoptee scholars’ experiences of, and reflections upon, their activism, emphasising the unique ways in which being subject to adoption complicates and constrains action. Adoptees’ struggles for recognition are somewhat perpetuated rather than resolved through activism, evidencing the self- reinforcing power of the institution of adoption.
Experimental and numerical investigations on large fuselage configurations
Creators: name:  ARNOULT GUILLAUME
name:   ANTONAKIS ARISTEIDIS
name:   ATINAULT OLIVIER
name:   BARETTER ALBERTO
name:   DELVA JEROME
name:   MEHEUT MICHAEL
name:   NOWINSKI VIANNEY
name:   TOUSSAINT CLEMENT
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: LARGE FUSELAGE
EXPERIMENTAL
NUMERICAL

description: The wide fuselage configuration is regarded as one of the most promising candidates for improving the fuel efficiency of business jet aircraft by increasing the cabin internal volume. In this article, several such configurations are investigated both numerically and experimentally to evaluate the impact of fuselage shape on aerodynamic performance and stability, including a wind tunnel test campaign at the ONERA L 1 Lille wind tunnel. An analysis of the results is presented, comprising a parametric study on the interaction between fuselage width and tail configuration. Finally, an improved tail sizing process is proposed for the new configurations addressing the limitations of existing approaches. 1. Background The fuel consumption reduction is one of the major challenges for the design of new aircraft. One way to attain this objective consists in increasing the width of the fuselage and thus its internal volume, leading to an overall reduction of the fuel consumption per square meter of cabin space. The concept of a wide fuselage has previously been studied by Drela [l] through the development of the DS aircraft concept and by Wiart et al. [2] with the additional aim of integrating the engines into the fuselage. In the scope of the European Clean Sky 2 (ITD Airframe), ONERA and DLR investigated several unconventional aircraft solutions that could significantly reduce the environmental impact of air transportation in the near future for S:tvlR (Small-Medium Range) and business jet missions. For this second mission, the wide-fuselage configuration (referred as LF hereafter) is one of the most promising concepts. In the frame of the project, several tail shapes were selected to equip this configuration with a view to exploring the design space and identifying the associated performance tradeoffs. An illustration of the tested configurations is presented in Table 1; derivatives with varying engine positions were also added during the campaign. As described above, the overall objective of this study was the evaluation and comparison of several tail design and fuselage width configurations for business jets from a stability and performance standpoint. To this end, variablefidelity tools were used during the process to size or validate the potential of each design. In the following paragraphs, a description of the overall methodology is given, followed by details on the element sizing and model manufacturing procedures. Copyright 2023 by First Author. Posted online by the EU CASS association with permission.
OPEN-QUAL - Innovating Methods for Open Science in Qualitative Management Research
Creators: name: Berends, Hans
name: Khadjavi Pour, Kacana
name: Braukmann, Ricarda
name: Haynes, Eric
name: Deken, Fleur
Publisher: name: Zenodo
Year: 2023

description: Slides of the presentation given at the event "I want to be FAIR - How to deal with my qualitative data?" Sharing qualitative data obtained in management research has been constrained by concerns for data privacy and confidentiality. OPEN-QUAL develops methodological principles for an innovative, decentralised approach to qualitative data reuse with no sharing of raw data. In this presentation, we present initial experiences obtained with this approach in a pilot study.
Pulsations in A- and F-type stars: Challenges and prospects
Creators: name: Zwintz, Konstanze
Publisher: name: Zenodo
Year: 2024

description: A and F stars are exceptional laboratories characterized and shaped by a large diversity of physical processes acting in them. These processes include varying rotational speeds, a wide range of chemical compositions, and magnetic fields and activity resulting in spots on the stellar surfaces. Pulsating A- and F-type stars can be found in very different evolutionary stages as well — from the pre-main sequence to the ZAMS and up to the post-main-sequence phase — which corresponds to quite different interior structures. Asteroseismic analyses of A and F stars are challenged by the interplay of these physical processes. But at the same time this diversity provides ideal conditions for advancing our knowledge of stellar physics and is crucial for refining models of stellar evolution. In this presentation, I will review recent findings from studies on AF pulsators and address key challenges that still hinder our complete understanding of these stars.
Struktureller Verrat
Creators: name: Ammicht Quinn, Regina
name: Haker, Hille
name: Junker-Kenny, Maureen
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 40 Nr. 3 (2004): Concilium: Internationale Zeitschrift für Theologie, Band 40, Heft 3
Numerical computation of diffusion on a surface
Creators: name: Adalsteinsson, D.
name: Colella, P.
name: Schwartz, P.
name: Arkin, A. P.
name: Onsum, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We present a numerical method for computing diffusive transport on a surface derived from image data. Our underlying discretization method uses a Cartesian grid embedded boundary method for computing the volume transport in a region consisting of all points a small distance from the surface. We obtain a representation of this region from image data by using a front propagation computation based on level set methods for solving the Hamilton–Jacobi and eikonal equations. We demonstrate that the method is second-order accurate in space and time and is capable of computing solutions on complex surface geometries obtained from image data of cells.
New Zealand's Alliance Obligations in a China-Australia War
Creators: name: Ayson, Robert
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: 160699 Political Science not elsewhere classified
subject: FOS: Political science
subject: 160599 Policy and Administration not elsewhere classified

description: Amidst concerns that Australia may end up in a military confrontation with China, this article evaluates New Zealand’s formal and informal alliance obligations in such an event. In keeping with Wellington’s current declaratory policy, New Zealand’s obligations would be most pressing if the attack occurred on or near Australia, although these would be less clear if China favoured coercion over violence. New Zealand is also likely to have strong alliance obligations if Australian forces were attacked in the South Pacific, the leading area for Australia-New Zealand security cooperation. If Australian forces were attacked in East Asia, New Zealand may have some obligations under the trilateral ANZUS Treaty despite the suspension of Washington’s commitments to Wellington under the same agreement. While New Zealand’s military capacity to assist Australia in maritime East Asia is limited, this is where a serious clash involving Australian and Chinese forces seems most likely. Enlarging the geographical focus of the trans-Tasman alliance may be logical in this new setting, but it could also be hazardous.
Early-warning system: Climate-smart spatial management of UK fisheries, aquaculture and conservation. A report of the NERC/ESRC Marine Spatial Planning Addressing Climate Effects project
Creators: name: Queirós, A.
name: Kay, S.
name: Sciberras, M.
name: Kaiser, M.
name: Wilson, R.J.
name: Sailley, S.
name: Marra, S.
name: Matear, L.
name: Fernandes, J.
name: Aldridge, J.
name: McEwan, R.
name: Morris, K.
name: McNeill, C.L.
name: Nunes, J.
name: Lynam, C.
name: Vina-Herbon, C.
name: Boulcott, P.
name: Hunter, B.
name: Parker, R.
name: Robinson, K.
name: Sweeting, C.
name: Frost, M.
name: Somerfield, P.J.
Publisher: name: Marine Climate Change Impacts Partnership (MCCIP), Lowestoft, UK
Year: 2023

description: A report of the NERC/ESRC Marine Spatial Planning Addressing Climate Effects project
Parallel evolution of chimeric fusion genes
Creators: name: Begun, D. J.
name: Jones, C. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: To understand how novel functions arise, we must identify common patterns and mechanisms shaping the evolution of new genes. Here, we take advantage of data from three Drosophila genes, jingwei, Adh-Finnegan, and Adh-Twain, to find evolutionary patterns and mechanisms governing the evolution of new genes. All three of these genes are independently derived from Adh, which enabled us to use the extensive literature on Adh in Drosophila to guide our analyses. We discovered a fundamental similarity in the temporal, spatial, and types of amino acid changes that occurred. All three genes underwent rapid adaptive amino acid evolution shortly after they were formed, followed by later quiescence and functional constraint. These genes also show striking parallels in which amino acids change in the Adh region. We showed that these early changes tend to occur at amino acid residues that seldom, if ever, evolve in Drosophila Adh. Changes at these slowly evolving sites are usually associated with loss of function or hypomorphic mutations in Drosophila melanogaster. Our data indicate that shifting away from ancestral functions may be a critical step early in the evolution of chimeric fusion genes. We suggest that the patterns we observed are both general and predictive.
Urban Biomimicry for Flood Mitigation Using an Ecosystem Service
Creators: name: MacKinnon, Maggie
name: Zari, Maibritt Pedersen
name: Brown, Daniel
name: Benavidez, Rubianca
name: Jackson, Bethanna
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: subject: 50211 Wildlife and Habitat Management
subject: FOS: Earth and related environmental sciences
subject: 50101 Ecological Impacts of Climate Change
subject: 50102 Ecosystem Function

description: No description supplied
Hohe Versammlung! Vertreter des deutschen Volkes! In Ehrfurcht und hoffendem Vertrauen wenden wir uns an Euch, erwählte Männer, berufen, um die Freiheit und die Rechte des deutschen Volkes festzustellen und zu schützen, ...; [um 1848]
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel
Dynamic workflow generation applied to aircraft moveable architecture optimization
Creators: name:  J.S. SONNEVELD
name:   T. VAN DEN BERG
name:   G. LA ROCCA
name: S. VALENCIA-IBANEZ, B. VAN MANEN
name:   A.M.R.M. BRUGGEMAN
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: DEFAINE
MDO

description: This paper discusses the approach for architecture design space optimization of aeronautical systems investigated in the DEF AINE project [l]. In system architecture optimization problems, hierarchical relations between design variables may exist. This means that the quantity and type of some variables are dependent on the value of other variables. To address this challenge, a nested optimization strategy is proposed, where an outer loop deals with the independent design variables and an inner loop with the dependent ones. As the characteristics of the dependent variables may become known only during workflow execution, a dynamic workflow formulation approach is developed to introduce these variables into the MDAO workflow, automatically, during execution. The proposed methodology is implemented using a suite of technologies provided by partners of the DEF AINE consortium to enable formulation and execution of collaborative MDAO problems. This implementation is then applied to the design and optimization of the structural layout of a UA V aileron. The goal is to minimize the aileron mass, subjected to failure criteria constraints. In this use case, hierarchical relations between variables are present. The aileron skin is discretised into material zones, each one defined by a (dependent) design variable. The nurn ber of zones, hence the number of design variables, is not known a priori as it depends on the number and position of ribs and spars (both independent variables). A preliminary implementation of the proposed approach proved effective in dealing with the hierarchical mixed-integer design space. Trade off studies comparing different aileron architectures could be efficiently set up and executed. Some limitations in the implemented workflow management technology, however prevent performing a full nested architecture optimization. Therefore, to demonstrate the effectiveness of the proposed nested approach, a parallel study was conducted on the same aileron, using a less generic and manual implementation of the nested MDAO workflow. This second study successfully minimized the mass and cost of the aileron structure, thereby proving the merit of the proposed nested approach to address system architecture optimization. Copyright 2023 by First Author. Posted online by the EU CASS association with permission.
Automated Fish Classification Using Unprocessed Fatty Acid Chromatographic Data: A Machine Learning Approach
Creators: name: Wood, Jesse
name: Nguyen, Hoai
name: Xue, Bing
name: Zhang, Mengjie
name: Killeen, D
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: Fish is approximately 40% edible fillet. The remaining 60% can be processed into low-value fertilizer or high-value pharmaceutical-grade omega-3 concentrates. High-value manufacturing options depend on the composition of the biomass, which varies with fish species, fish tissue and seasonally throughout the year. Fatty acid composition, measured by Gas Chromatography, is an important measure of marine biomass quality. This technique is accurate and precise, but processing and interpreting the results is time-consuming and requires domain-specific expertise. The paper investigates different classification and feature selection algorithms for their ability to automate the processing of Gas Chromatography data. Experiments found that SVM could classify compositionally diverse marine biomass based on raw chromatographic fatty acid data. The SVM model is interpretable through visualization which can highlight important features for classification. Experiments demonstrated that applying feature selection significantly reduced dimensionality and improved classification performance on high-dimensional low sample-size datasets. According to the reduction rate, feature selection could accelerate the classification system up to four times.
Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats
Creators: name: Wassum, K. M.
name: Wightman, R. M.
name: Khan, A. S.
name: Heien, M. L. A. V.
name: Phillips, P. E. M.
name: Ariansen, J. L.
name: Cheer, J. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Dopamine neurotransmission has been implicated in the modulation of many cognitive processes. Both rapid (phasic) and slower (tonic) changes in its extracellular concentration contribute to its complex actions. Fast in vivo electrochemical techniques can measure extracellular dopamine on a rapid time scale but without the selectivity afforded with slower techniques that use chemical separations. Cyclic voltammetry improves chemical resolution over other electrochemical methods, and it can resolve dopamine changes in the brains of behaving rodents over short epochs (<10 s). With this method, however, selective detection of slower dopamine changes is still elusive. Here we demonstrate that principal component regression of cyclic voltammetry data enables quantification of changes in dopamine and extracellular pH. Using this method, we show that cocaine modifies dopamine release in two ways: dopamine concentration transients increase in frequency and magnitude, whereas a gradual increase in steady-state dopamine concentration occurs over 90 s.