cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
Creators: name: Mitroi, Daniel N.
name: Indulekha Karunakaran
name: Gräler, Markus
name: Saba, Julie D.
name: Ehninger, Dan
name: Ledesma, María Dolores
name: Echten-Deckert, Gerhild Van
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology

description: Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate lyase 1) in autophagy are increasingly recognized. Here we provide in vitro and in vivo evidence for a previously unidentified route through which SGPL1 modulates autophagy in neurons. SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. In the brains of SGPL1fl/fl/Nes mice with developmental neural specific SGPL1 ablation, we observed significantly reduced PE levels. Accordingly, alterations in basal and stimulated autophagy involving decreased conversion of LC3-I to LC3-II and increased BECN1/Beclin-1 and SQSTM1/p62 levels were apparent. Alterations were also noticed in downstream events of the autophagic-lysosomal pathway such as increased levels of lysosomal markers and aggregate-prone proteins such as APP (amyloid β [A4] precursor protein) and SNCA/α-synuclein. In vivo profound deficits in cognitive skills were observed. Genetic and pharmacological inhibition of SGPL1 in cultured neurons promoted these alterations, whereas addition of PE was sufficient to restore LC3-I to LC3-II conversion, and control levels of SQSTM1, APP and SNCA. Electron and immunofluorescence microscopy showed accumulation of unclosed phagophore-like structures, reduction of autolysosomes and altered distribution of LC3 in SGPL1fl/fl/Nes brains. Experiments using EGFP-mRFP-LC3 provided further support for blockage of the autophagic flux at initiation stages upon SGPL1 deficiency due to PE paucity. These results emphasize a formerly overlooked direct role of SGPL1 in neuronal autophagy and assume significance in the context that autophagy modulators hold an enormous therapeutic potential in the treatment of neurodegenerative diseases.
How do gender quotas affect public support for women as political leaders?
Creators: name: Allen, Peter
name: Cutts, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Gender quotas have shown themselves to be an effective means of getting more women into political office. Less clear is the broader effect of gender quotas on egalitarian attitudes. This article uses a cross-national dataset of 48 countries worldwide to examine the role of gender quotas in the generation of individual-level attitudes to women as political leaders. Firstly, gender quotas appear to improve perceptions of women’s ability as political leaders in countries where they are present, having controlled for a range of individual-level and contextual influences. Second, this effect differs by sex. For women, the presence of gender quotas alone increases their support for women’s political leadership, something theorised as a ‘vote of confidence’ effect. Thirdly, this effect is not dependent on the type of quota implemented and holds for quotas adopted voluntarily by political parties and those that are brought about via a broader legal change.
Eclesiologia para um mundo plural e contraditório : elementos de criteriologia e indicações prático-pastorais
Creators: name: Pinho, José Eduardo Borges De
Publisher: name: Didaskalia
Year: 2007

description: O presente texto centra-se na questão da “Eclesiologia” (não simplesmente da “Igreja”) num mundo marcado pela pluralidade e por sinais de sentido contraditório. Nessa perspectiva tem, sobretudo, como horizonte de reflexão os pressupostos hermenêuticos e os elementos de criteriologia indispensáveis em termos de identidade e missão da Igreja nestas circunstâncias. Ao mesmo tempo, põem-se em relevo algumas orientações práxicas que importa considerar em ordem ao futuro. A partir da visão eclesiológica decorrente do Concílio Vaticano II e da recepção conciliar em curso, tomadas como ponto de referência, o artigo estrutura-se em seis pontos, cada um deles com uma primeira parte voltada para a fundamentação de princípio (os elementos de criteriologia) e uma segunda parte mais centrada nas consequências prático-pastorais que decorrem desses critérios. Chama-se assim a atenção para a importância da consciência histórica em eclesiologia, para o critério fundamental do serviço ao Reinado de Deus que suporta a missão da Igreja, para a importância da dimensão comunitária em todas as suas consequências. Reflecte-se, a seguir, sobre a visão da Igreja como unidade na diversidade, sobre a configuração da Igreja inteira como comunhão de Igrejas e, ainda, sobre o significado eclesiológico do diálogo enquanto atitude fundamental de vida num mundo plural e contraditório.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
Toward Facile Preparation and Design of Mulberry-Shaped Poly(2-methylaniline)-Ce2(WO4)3@CNT Nanocomposite and Its Application for Electrochemical Cd2+ Ion Detection for Environment Remediation
Creators: name: Anish Khan
name: Khan, Aftab Aslam Parwaz
name: Rahman, Mohammed M.
name: Asiri, Abdullah M.
name: Alfaifi, Sulaiman Y. M.
name: Taib, Layla A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Plant Biology
subject: 60506 Virology

description: Novel hybrid material was prepared by adding slurries of poly(N-methylaniline) and cerium tungstate [Ce2(WO4)3] into a conical flask contained dispersed carbon nanotubes. It was characterized by scanning electron microscope, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Electrical conductivity of poly(N-methylaniline)-Ce2(WO4)3@carbon nanotube samples was determined using four-probe method. The thin layer of poly(N-methylaniline)-Ce2(WO4)3@carbon nanotube was fabricated onto glassy carbon electrode for a selective Cd2+ ion sensor. The calibration plot is linear (r2 = 0.9917) over the large Cd2+ concentration ranges (1.0 nM–1.0 mM). The sensitivity, detection limit is ∼5.138 µA µM−1 cm−2 and ∼0.11 nM (signal-to-noise ratio, at a SNR of 3), respectively.
Uma definição espiritual do Tempo como ‘eternidade começada e sempre em progresso’ – ou o ensinamento do Céu na Terra segundo Elisabeth de la Trinité
Creators: name: Silva, Carlos Henrique Do Carmo
Publisher: name: Didaskalia
Year: 2007

description: O presente estudo pretende analisar uma expressão que a bem-aventurada carmelita, Isabel da Trindade, usa – quer em O Céu na Terra, quer no Último Retiro – para definir o tempo, e cuja origem exacta é desconhecida. Após uma introdução em que se situa o problema da temporalidade no contexto e ritmo da sua experiência espiritual, invocam-se quadros tradicionais de referência a esse problema, salientando sobretudo os paradigmas platónicos (ou neoplatónicos) que influíram na concepção reflectida pela corrente mística. Numa segunda parte, discute-se a noção de eternidade – da ‘eternidade começada’ implícita em Isabel da Trindade e oscilando entre o sentido de continuidade temporal, ou do seu anulamento. Depois, considera-se a conjugação diferencial do sentido de um ‘progresso’ eterno ou, antes, de uma interpretação do tempo como recorrência de um estado perpétuo. Conclui-se por esta ‘terceira’ dimensão do tempo, nem celeste e eterno, nem do devir terreno, mas como se ao modo do aevum, o que espelha ainda a tensão crucial e a experiência trinitária do seu carisma espiritual.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
Nem acaso, nem necessidade : o jogo como metáfora da criação
Creators: name: Varanda, Isabel
Publisher: name: Didaskalia
Year: 2007

description: A hipótese deste estudo consiste em considerar a categoria de jogo como elemento epistemológico e hermenêutico para pensar teologicamente a criação. Desta hipótese derivam, certamente, implicações na compreensão do cosmos e de todas as criaturas, particularmente da criatura humana – é o que procuraremos mostrar – mas também tem implicações na representação de Deus. Em perspectiva teológica, pensar a criação como jogo faz aparecer, em toda a sua singularidade, o universo de liberdade da Criação, das criaturas e do Criador, para lá de toda e qualquer finalidade, causa ou arbítrio; o universo da gratuidade, do dom, da graça, para lá da necessidade e do constrangimento. Pensar a criação como jogo coloca-nos no coração de um dinamismo de transcendência que nos atravessa, nos constrói e nos significa uma Alteridade que, no seu Algures Absoluto, paradoxalmente nos constitui. Falta, então, perceber o que o jogo diz de verdade sobre a criatura humana e perceber também o poder deste existencial de dizer algo de Deus e do que está em jogo na criação. É o objectivo do presente estudo.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
«De graça recebestes, de graça dai»
Creators: name: Couto, António
Publisher: name: Didaskalia
Year: 2007

description: O texto tece-se como uma glosa do dito de Jesus «De graça recebestes, de graça dai», registrado no Evangelho de Mt 10,8. Recolhe a linguagem da graça do AT e do NT, que mostra a premura maternal de um Deus atento e carinhoso que olha com amor pelos seus filhos e para os seus filhos, e que desenha perante o nosso egoísmo, auto-suficiência, exclusão e egocentrismo, novos horizontes de abertura, de inclusão e de partilha. Também contrapõe ao nosso mundo de posse o novo modelo de receber e dar. Nasce assim uma nova familiaridade e uma nova fraternidade. S. Francisco de Assis é apresentado como modelo de recepção na sua vida do texto de Mateus acima referido.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders
Creators: name: Law, Kelsey B.
name: Bronte-Tinkew, Dana
name: Pietro, Erminia Di
name: Snowden, Ann
name: Jones, Richard O.
name: Moser, Ann
name: Brumell, John H.
name: Braverman, Nancy
name: Kim, Peter K.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer

description: Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. The majority of PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) required for cycling PEX5 for peroxisomal matrix protein import. Mutations in these genes are thought to result in a defect in peroxisome assembly by preventing the import of matrix proteins. However, we show here that loss of the AAA-complex does not prevent matrix protein import, but instead causes an upregulation of peroxisome degradation by macroautophagy, or pexophagy. The loss of AAA-complex function in cells results in the accumulation of ubiquitinated PEX5 on the peroxisomal membrane that signals pexophagy. Inhibiting autophagy by genetic or pharmacological approaches rescues peroxisome number, protein import and function. Our findings suggest that the peroxisomal AAA-complex is required for peroxisome quality control, whereas its absence results in the selective degradation of the peroxisome. Thus the loss of peroxisomes in PBD patients with mutations in their peroxisomal AAA-complex is a result of increased pexophagy. Our study also provides a framework for the development of novel therapeutic treatments for PBDs.
Isolation of a new butenolide from the South China Sea gorgonian coral Subergorgia suberosa
Creators: name: Zhang, Jun
name: Liang, Yan
name: Liao, Xiao-Jian
name: Deng, Zhou
name: Xu, Shi-Hai
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Chemical investigation on the South China Sea gorgonian coral Subergorgia suberosa has led to the isolation of one new butenolide (5R)-5-(1-ethoxypropyl)-5-hydroxy-3,4-dimethylfuran-2(5H)-one (1) as a pair of inseparable epimers, along with two known butenolides (S)-5-hydroxy-3,4-dimethyl-5-propylfuran-2(5H)-one (2) and (S)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one (3). Their structures including absolute configurations were determined unambiguously by detailed analyses of spectroscopic data and by comparison with the available literature. Compounds 1–3 exhibited moderate antifouling activities against the settlement of Balanus amphitrite larvae, whereas compound 4, the acetyl derivative of 3, showed no antifouling activity at the concentrations up to 25 μg/mL.
As declinações do amor : uma curiosidade do texto lucano
Creators: name: Mendonça, José Tolentino
Publisher: name: Didaskalia
Year: 2007

description: É sabido como Lucas concede uma atenção profunda à singularidade do estatuto de Jesus, recorrendo a um grande número de tipologias narrativas. Um exemplo curioso, e que se soma a esses, é, porém, de natureza lexical: o das declinações do verbo amar. Dentre os Sinópticos, é este Evangelista quem faz um emprego mais numeroso desse verbo. Nele também, sempre que o verbo é significativo, ocorre nos discursos de Jesus. Sem dúvida que o seu sentido, em parte, prolonga quanto estava já fixado na tradição veterotestamentária, onde uma experiência de amor une o Deus da Aliança ao povo escolhido, através da fidelidade às exigências concretas da Lei (Ex 19,3-8). Mas em Lucas, o verbo amar é, para além disso, declinado em modo absoluto. E essa originalidade funciona como dispositivo de intensificação (verbal e teológica), anunciando não apenas a autoridade inédita com que Jesus desenvolve o seu programa profético, mas possibilitando o reconhecimento, na Fé, da sua identidade e do seu poder de Salvação. Mesmo aos que se situam “fora da Lei”.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
Students’ motivation toward feedback-seeking in the clinical workplace
Creators: name: Lubberta H. De Jong
name: Favier, Robert P.
name: Vleuten, Cees P. M. Van Der
name: Bok, Harold G. J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Hematology

description: In medical education, students are increasingly regarded as active seekers of feedback rather than passive recipients. Previous research showed that in the intentions of students to seek feedback, a learning and performance goal can be distinguished. In this study, we investigated the intentions (defined as level and orientation of motivation) of different performing students (low, average, and high performing students) to seek feedback in the clinical workplace using Self-Determination Theory. We conducted a quantitative study with students in their clinical clerkships and grouped them based on their performance. The level of motivation was measured by the number of Mini-CEXs each student collected. The orientation of motivation was measured by conducting the Academic Self-Regulation Questionnaire. We found that high performing students were more motivated and demonstrated higher self-determination compared to low performing students.
O acolhimento pastoral: perspectivas teológicas e antropológicas
Creators: name: Nunes, José
Publisher: name: Didaskalia
Year: 2007

description: O acolhimento é um desafio fundamental e permanente para a pastoral da Igreja e, afinal, uma experiência estruturante da vida de toda a pessoa: as ciências humanas repetem à saciedade que o acolhimento recíproco, o amar e sentir-se amado, é o que mais equilibra o ser humano. O percurso que aqui propomos começa por uma fundamentação teológica do acolhimento, isto é, do acolhimento que tem a Deus por sujeito, em particular a partir das características básicas da ‘condescendência’ e da ‘misericórdia’. Em seguida, buscaremos algumas notas importantes da praxis de acolhimento de Jesus, tomando para isso três textos bem concretos dos evangelhos. Finalmente, procuraremos destacar alguns campos e perspectivas onde o acolhimento mais urge na nossa pastoral das paróquias, movimentos ou outras realidades.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
title: 01_2562
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Evaluating oxidation–reduction properties of dissolved organic matter from Chinese milk vetch (Astragalus sinicus L.): a comprehensive multi-parametric study
Creators: name: Liu, Yong
name: Lou, Jun
name: Li, Fang-Bai
name: Xu, Jian-Ming
name: Yu, Xiong-Sheng
name: Zhu, Li-An
name: Wang, Feng
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Environmental Science

description: Green manuring is a common practice in replenishment of soil organic matter and nutrients in rice paddy field. Owing to the complex interplay of multiple factors, the oxidation–reduction (redox) properties of dissolved organic matter (DOM) from green manure crops are presently not fully understood. In this study, a variety of surrogate parameters were used to evaluate the redox capacity and redox state of DOM derived from Chinese milk vetch (CMV, Astragalus sinicus L.) via microbial decomposition under continuously flooded (CF) and non-flooded (NF) conditions. Additionally, the correlation between the surrogate parameters of CMV–DOM and the kinetic parameters of relevant redox reactions was evaluated in a soil–water system containing CMV–DOM. Results showed that the redox properties of CMV–DOM were substantially different between the fresh and decomposed CMV–DOM treatments. Determination of the surrogate parameters via ultraviolet–visible/Fourier transform infrared absorption spectroscopy and gel permeation chromatography generally provided high-quality data for predicting the redox capacity of CMV–DOM, while the surrogate parameters determined by elemental analysis were suitable for predicting the redox state of CMV–DOM. Depending on the redox capacity and redox state of various moieties/components, NF-decomposed CMV–DOM could easily accelerate soil reduction by shuttling electrons to iron oxides, because it contained more reversible redox-active functional groups (e.g. quinone and hydroquinone pairs) than CF-decomposed CMV–DOM. This work demonstrates that a single index cannot interpret complex changes in multiple factors that jointly determine the redox reactivity of CMV–DOM. Thus, a multi-parametric study is needed for providing comprehensive information on the redox properties of green manure DOM.
Exploring 3D non-interpenetrated metal–organic framework with malonate-bridged Co(II) coordination polymer: structural elucidation and theoretical study
Creators: name: Anowar Hossain
name: Mandal, Tripti
name: Monojit Mitra
name: Prankrishna Manna
name: Bauzá, Antonio
name: Frontera, Antonio
name: Saikat Kumar Seth
name: Mukhopadhyay, Subrata
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: A Co(II)-based coordination polymer with tetranuclear cobalt(II)-malonate cluster has been easily generated by aqueous medium self-assembly from Cobalt(II) chloride hexahydrate and malonic acid. The structure exhibits a non-interpenetrating, highly undulating two-dimensional (2D) bi-layer network with (4,4) topology. The crystal structure is composed of infinite interdigitated 2D metal–organic bi-layers which extended to an intricate 3D framework through the interbilayer hydrogen bonds. We have studied energetically by means of Density Functional Theory (DFT) calculations the H-bonding interactions that connect the 2D metal–organic bi-layers. The finite theoretical models have been used to compute conventional O‒H∙∙∙O and unconventional C‒H∙∙∙O interactions which plays a key role to build 3D architecture.
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
Creators: name: Mitroi, Daniel N.
name: Indulekha Karunakaran
name: Gräler, Markus
name: Saba, Julie D.
name: Ehninger, Dan
name: Ledesma, María Dolores
name: Echten-Deckert, Gerhild Van
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology

description: Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate lyase 1) in autophagy are increasingly recognized. Here we provide in vitro and in vivo evidence for a previously unidentified route through which SGPL1 modulates autophagy in neurons. SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. In the brains of SGPL1fl/fl/Nes mice with developmental neural specific SGPL1 ablation, we observed significantly reduced PE levels. Accordingly, alterations in basal and stimulated autophagy involving decreased conversion of LC3-I to LC3-II and increased BECN1/Beclin-1 and SQSTM1/p62 levels were apparent. Alterations were also noticed in downstream events of the autophagic-lysosomal pathway such as increased levels of lysosomal markers and aggregate-prone proteins such as APP (amyloid β [A4] precursor protein) and SNCA/α-synuclein. In vivo profound deficits in cognitive skills were observed. Genetic and pharmacological inhibition of SGPL1 in cultured neurons promoted these alterations, whereas addition of PE was sufficient to restore LC3-I to LC3-II conversion, and control levels of SQSTM1, APP and SNCA. Electron and immunofluorescence microscopy showed accumulation of unclosed phagophore-like structures, reduction of autolysosomes and altered distribution of LC3 in SGPL1fl/fl/Nes brains. Experiments using EGFP-mRFP-LC3 provided further support for blockage of the autophagic flux at initiation stages upon SGPL1 deficiency due to PE paucity. These results emphasize a formerly overlooked direct role of SGPL1 in neuronal autophagy and assume significance in the context that autophagy modulators hold an enormous therapeutic potential in the treatment of neurodegenerative diseases.
A Defining Moment: Malaysian Nurses' Perspectives of Trans-National Higher Education
Creators: name: Arunasalam, Nirmala
Publisher: name: University of Hertfordshire
Year: 2013
Subjects: TNHE
Nurses
Malaysia
Post-registration nursing programmes
Intercultural teaching and learning
Learning Shock

description: Abstract Transnational Higher Education (TNHE) post-registration top-up nursing degree programmes are relatively new in Malaysia and their impact in clinical settings is unknown. This research interprets Malaysian nurses’ experiences of such programmes and their perspectives of the extent TNHE theoretical knowledge has been applied in clinical settings. The contextual framework was established by drawing on a range of relevant dominant discourses, i.e. TNHE, nurse education, continuous professional development, theory-practice link in nursing, and culture and its influences, including coping with and adjusting to new ways of learning. Hermeneutic phenomenology and the ethnographic principle of cultural interpretation were used to explore the views of eighteen Malaysian nurses from two UK and one Australian TNHE universities (determined by convenience and snowball sampling methods) to enable data saturation. Semi-structured interviews were conducted to enable the nurses’ voices to define, describe and evaluate their TNHE experiences that were focused on personal and professional development, implementation and reaction of others towards change. In addition to the interviews, three threads of my own personal, professional and researcher experiences were reflected upon, to provide the contextual lens to shape the research process and situate the work firmly in the practice context. Data was analysed using thematic analysis. Four pre-determined key areas drawn from the literature were investigated and eight new sub-themes emerged. Findings indicated nurses’ improved self-confidence, knowledge, questioning skills and professionalism. The extent to which TNHE theory was applied in clinical practice was unable to be determined due to conflicting perceptions, contradicting views and restricted number of nurse-led examples. The main contribution this thesis offers to practice is what the voices of nurses tell about their experiences in TNHE programmes and in applying the taught theory in clinical settings. This study indicates enhanced application of theoretical knowledge in practice for improved quality and culturally competent patient care is unlikely to occur under current TNHE arrangements. Nurses’ motives for enrolling were mainly to obtain the high status western degree and the extrinsic benefits of a financial incentive and promotion. However, drawing on their resilience, nurses developed self and professional perspective transformation. The research provides new insights to inform continuous professional education policy for nurses, employers and the Malaysian Nursing Board, and can assist TNHE provider institutions to improve their programme delivery.
Towards Facile Preparation and Design of Mulberry Shaped Poly(N–Methylaniline)Ce2(WO4)3@CNT Nanocomposite and Its Application for Electrochemical Cd2+ Ions Detection for Environment Remediation
Creators: name: Anish Khan
name: Khan, Aftab Aslam Parwaz
name: Rahman, Mohammad M.
name: Asiri, Abdullah M.
name: Alfaifi, Sulaiman Y. M.
name: Taib, Layla A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Novel hybrid material was prepared by adding slurries of poly(2–methylaniline) (PNMA) and cerium tungstate (Ce2(WO4)3 or CWO) into a conical flask contained dispersed carbon nanotubes (CNTs). It was characterized by XPS, SEM, XRD, FTIR and TGA. Electrical conductivity of PNMA–Ce2(WO4)3@CNT samples were determined using four–probe method. The thin–layer of PNMA–CWO@CNT was fabricated onto glassy carbon electrode (GCE) for a selective Cd2+ ions sensor. The calibration plot is linear (r2 = 0.9917) over the large Cd2+ concentration ranges (1.0 nM to 1.0 mM). The sensitivity, detection limit is ∼ 5.138 µA.µM−1.cm−2 and ∼0.11 nM (signal–to–noise ratio, at a SNR of 3) respectively.
Understanding the Effect of Tamarind Gum Proportion on the Properties of Tamarind Gum-Based Hydroethanolic Physical Hydrogels
Creators: name: Suprio R. Paul
name: Nayak, Suraj K.
name: Yogalakshmi, Yamini
name: Singh, Vinay K.
name: Rath, Archana
name: Indranil Banerjee
name: Arfat Anis
name: Kunal Pal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: The present study reports the analysis of properties of tamarind gum-based hydroethanolic physical hydrogels. The extent of hydrogen bonding in hydrogels decreased with an increase in tamarind gum content. The hydrogel with the highest tamarind gum content was found to be highly stable in terms of mechanical properties. There was a decrease in the resistive component of the hydrogels with an increase in tamarind gum content. The drug release from the hydrogels increased with an increase in the tamarind gum content. The antimicrobial activity of the drug-loaded hydrogels against Escherichia coli was excellent.
Chemical components of Hyssopus cuspidatus Boriss.: isolation and identification, characterization by HPLC-DAD-ESI-HRMS/MS, antioxidant activity and antimicrobial activity
Creators: name: Shomirzoeva, Omina
name: Li, Jun
name: Numonov, Sodik
name: Atolikshoeva, Sunbula
name: Aisa, Haji Akber
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Biological Sciences not elsewhere classified

description: Eighteen compounds were isolated from the ethyl acetate fraction of the aerial part of Hyssopus cuspidatus. Their structures were established by analysis of mass and NMR data, as well as comparison with previous published data in the literatures. Among them, ten compounds were found from the Hyssopus genus for the first time, and one compound was isolated from H. cuspidatus for the first time. HPLC-DAD-ESI-HRMS/MS investigations was applied to further obtain the phenolic profiling of the ethyl acetate fraction, and nine derivatives of caffeic acid and ferulic or isoferulic acid were identified. Antioxidant activity against DPPH free radical and antibacterial activity against Candida albicans, Escherichia coli and Staphylococcus aureus were evaluated. The ethyl acetate fraction exhibited weak antioxidant activity and moderate antibacterial activity. The isolated compounds showed weak to potent antioxidant and antibacterial activity. To the best of our knowledge, this is the first report on the antioxidant and antibacterial activity of H. cuspidatus.
Synthesis and characterization of new pyrazole-based thiazoles
Creators: name: Abdelhamid, Abdou O.
name: Gomha, Sobhi M.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 60506 Virology

description: A series of new 5-(heteroaryldiazenyl)thiazole incorporating pyrazole moiety have been synthesized through coupling of the thiazole with the appropriate heteroaryldiazonium salts. The newly synthesized compounds were characterized by elemental analysis, spectroscopic (IR, 1H NMR, and Mass) data, and alternative synthesis whenever possible.
An Analysis of the Performance of the Term "Great Britain/British" from a Brand Perspective - 1603 to 1625
Creators: name: Hall, Eric Paterson
Publisher: name: University of Hertfordshire
Year: 2013
Subjects: James VI
James I
James VI and I
British History
Branding
Great Britain
Early Stuarts
Englishness
Britishness
United Kingdom

description: The dissertation takes the modern business technique/concept of brands and branding, applies them to a historic case study, the creation by James VI and I of Great Britain from 1603 to 1625, and by doing so throws new light on both. It compares two distinct approaches to branding, unidirectional and social interactionist, postulating that the latter would prove better at explaining the success of the brand Great Britain/British. The case study reveals that neither approach is supported by the evidence. Content analysis shows that there was a lack of awareness of the brand Great Britain/British and an inconsistency in its use, hence neither approach can be sustained. However, the same analysis does show that an alternative brand, England/English, existed in the same time and that this brand provides some limited support for the social interactionist view of brands and branding. The lack of success of the brand Great Britain/British during his reign does not appear to have prevented James VI and I from establishing himself as the legitimate King of England in addition to Scotland although the contribution of the brand to this was marginal at best.
Silver oxynitrate – an efficacious compound for the prevention and eradication of dual-species biofilms
Creators: name: Lemire, Joe A.
name: Kalan, Lindsay
name: Gugala, Natalie
name: Bradu, Alexandru
name: Turner, Raymond J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Preventing and eradicating biofilms remains a challenge in clinical and industrial settings. Recently, the present authors demonstrated that silver oxynitrate (Ag7NO11) prevented and eradicated single-species planktonic and biofilm populations of numerous microbes at lower concentrations than other silver (Ag) compounds. Here, the antimicrobial and anti-biofilm efficacy of Ag7NO11 is elaborated by testing its in vitro activity against combinations of dual-species, planktonic and biofilm populations of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. As further evidence emerges that multispecies bacterial communities are more common in the environment than their single-species counterparts, this study reinforces the diverse applicability of the minimal biofilm eradication concentration (MBEC™) assay for testing antimicrobial compounds against biofilms. Furthermore, this study demonstrated that Ag7NO11 had enhanced antimicrobial and anti-biofilm activity compared to copper sulfate (CuSO4) and silver nitrate (AgNO3) against the tested bacterial species.
Supplement-Appendix A.docx
Creators: name: Pratama, Aditya
Publisher: name: figshare
Year: 2017
Subjects: subject: 91005 Manufacturing Management
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The convergence condition of bucket brigades with worker collaboration with fully and partially cross-trained workers under a three-workstation, two-worker production line
The effectiveness of the internship in meeting established learning objectives: A qualitative study
Creators: name: Ahern, Susannah
name: Reid, Katharine
name: Temple-Smith, Meredith
name: McColl, Geoffrey J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy

description: Objective: To identify and explore variations in intern (Postgraduate Year 1 doctors) exposure to clinical activities defined by an established early postgraduate curriculum within the contemporary health service environment. Methods: A mixed methods study was undertaken in seven health services comprising (1) a questionnaire regarding interns’ exposure to a range of clinical activities within a two-year early post-graduate curriculum and (2) group interviews with intern supervisors and managers to explore barriers and facilitators of interns’ clinical exposure. Results: One hundred and eleven interns completed the questionnaire and seventeen intern supervisors and managers participated in group interviews. Interns’ exposure to early postgraduate curriculum activities varied significantly, with participation in patient emergency management and procedures being undertaken less frequently than interns wished. These findings were consistent across different regional settings. Of three mandatory terms, exposure to curriculum activities was greater in medicine and emergency medicine than in surgery. Conclusions: Junior doctors’ participation within the complex contemporary health service environment is constrained by barriers relating to clinical governance frameworks and health system performance, particularly in high-risk clinical activities. Solutions will require structural approaches to internship reform to ensure that placements provide the necessary safe clinical experiences required for intern training.
On the Influence of the Laser Illumination on the Logic Cells Current Consumption
Creators: name: Petryk, Dmytro
name: Dyka, Zoya
name: Krstic, Milos
name: Bělohoubek, Jan
name: Fišer, Petr
name: Steiner, František
name: Blecha, Tomáš
name: Langendörfer, Peter
name: Kabin, Ievgen
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cryptography and Security (cs.CR)
subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: Physical side-channel attacks represent a great challenge for today's chip design. Although attacks on CMOS dynamic power represent a class of state-of-the-art attacks, many other effects potentially affect the security of CMOS chips analogously by affecting mostly static behaviour of the chip, including aging, ionizing radiation, or non-ionizing illumination of the CMOS. Vulnerabilities exploiting data dependency in CMOS static power were already demonstrated in practice and the analogous vulnerability exploiting light-modulated static power was demonstrated by simulation. This work confirms the CMOS vulnerability related to the light-modulated data-dependent static power experimentally and discusses future work.
description: 8 figures
O Verbo, arquétipo da comunicação
Creators: name: Martins, Nuno Brás
Publisher: name: Didaskalia
Year: 2007

description: O artigo efectua uma leitura do vol. I da obra de H. U. Von Balthasar Herrlichkeit na perspectiva de um olhar teológico sobre a realidade da comunicação, procurando mostrar por um lado como este conceito é central no pensamento balthasariano e, por outro, como a própria Teologia tem uma palavra a dizer acerca da comunicação e do seu mundo. Assim, partindo do conceito central de «beleza», o artigo mostra como a encarnação do Verbo constitui a possibilidade de encontro e de comunicação entre Deus e o homem: Cristo é a Verdade – a verdade de Deus e a verdade do homem – e comunica-a comunicando-se, dando-nos a participar da sua vida.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
A condição laical no contexto dos Estados Eclesiais
Creators: name: Galvão, H. Noronha
Publisher: name: Didaskalia
Year: 2007

description: Se com "condição laical" se exprime melhor a complexidade da vocação e função dos leigos na Igreja, “estado laical” é expressão mais precisa usada pelo concílio Vaticano II (LG 30. AA 2). Deve ser definida pela sua contraposição aos outros estados eclesiais: o clerical (dos ministros ordenados) e o religioso (LG 30.31). Quer a unidade e comunhão da Igreja quer o ministério apostólico dos Doze são originariamente constitutivos da Igreja. O mistério da Igreja na sua unidade comporta, porém, como ícone do Deus Trindade, o dinamismo protológico da criação pelo Pai, o dinamismo soteriológico da redenção por Jesus Cristo e o dinamismo escatológico da santificação e consumação pelo Espírito Santo. Podemos ver cada um dos três estados eclesiais – laical, clerical, religioso – marcado por um determinado carisma ao serviço de cada um desses dinamismos. É neste sentido que a “índole secular” dos cristãos leigos os insere na comunhão eclesial por um serviço de evangelização do mundo.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
A Filosofia Moral de São Tomás de Aquino
Creators: name: Teixeira, Joaquim De Sousa
Publisher: name: Didaskalia
Year: 2007

description: “Este breve estudo, semelhante a uma crónica filosófica, pretende recordar três teses sobre a ‘filosofia’ moral de S. Tomás de Aquino, nem sempre tidas na devida conta: em primeiro lugar, a novidade da introdução da ética aristotélica apenas na segunda parte, sobretudo na primeira secção, da Suma de Teologia; a seguir, os motivos da introdução de uma ética filosófica, disciplina da razão prática, numa teologia vincadamente especulativa; por último, a ruptura parcial protagonizada por S. Tomás face ao tradicional enquadramento agostiniano-anselmiano da ética.»
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
A evidência de Jesus: anúncio e narratividade
Creators: name: Pinho, Arnaldo De
Publisher: name: Didaskalia
Year: 2007

description: Segundo Ricoeur a terceira raiz do problema hermenêutico foi apenas compreendida pelos modernos, a partir justamente da compreensão do texto como kerigma. Sendo assim o texto bíblico guarda já uma narratividade especifica que exige ser retomada (“reprise”). Esta retoma consiste em levar o texto a sua evidência por uma adequada enunciação. Seria essa a tarefa, difícil tarefa, dos que lidam com o anúncio de Jesus.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
Understanding the effect of tamarind gum proportion on the properties of tamarind gum based hydroethanolic physical hydrogels
Creators: name: Suprio R. Paul
name: Nayak, Suraj K.
name: Yogalakshmi, Yamini
name: Singh, Vinay K.
name: Rath, Archana
name: Indranil Banerjee
name: Arfat Anis
name: Kunal Pal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: The present study reports the analysis of the properties of the tamarind gum based hydroethanolic physical hydrogels. The extent of hydrogen bonding in the hydrogels decreased with the increase in the tamarind gum content. The hydrogel with the highest tamarind gum content was found to be highly stable in terms of mechanical properties. There was a decrease in the resistive component of the hydrogels with the increase in the tamarind gum content. The drug release from the hydrogels increased with the increase in the tamarind gum content. The antimicrobial activity of the drug-loaded hydrogels against E. coli was excellent.
O encanto amoroso da verdade: um contributo para a história da mariologia em Portugal
Creators: name: Farias, José Jacinto Ferreira De
Publisher: name: Didaskalia
Year: 2007

description: O texto procura fazer uma relação comparativa entre duas obras mariológicas situadas em dois contextos históricos e culturais tão distintos, como seja a de António de Sousa Macedo, no séc. XVII e a Doutora Maria Manuela Carvalho, hoje, já no séc. XXI, para mostrar a continuidade, mas também a diferença metodológica e sistemática entre as duas abordagens e relevar a novidade e o contributo do trabalho teológico da Doutora Maria Manuela Carvalho, que é o objectivo deste ensaio de homenagem, que traduz também o apreço e a amizade que nos unem, como condiscípulos de longa data e peregrinos na mesma busca da verdade que constitui o logos da teologia.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho