cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Use of LC-MS/MS and Stable Isotopes to Differentiate Hydroxymethyl and Methyl DNA Adducts from Formaldehyde and Nitrosodimethylamine
Creators: name: Lu, Kun
name: Moeller, Benjamin C.
name: Nakamura, Jun
name: Swenberg, James A.
name: Craft, Sessaly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Formaldehyde is a known human and animal carcinogen that forms DNA adducts, and causes mutations. While there is widespread exposure to formaldehyde in the environment, formaldehyde is also an essential biochemical in all living cells. The presence of both endogenous and exogenous sources of formaldehyde makes it difficult to develop exposure-specific DNA biomarkers. Furthermore, chemicals such as nitrosodimethylamine form one mole of formaldehyde for every mole of methylating agent, raising questions about potential co-carcinogenesis. Formaldehyde-induced hydroxymethyl DNA adducts are not stable and need to be reduced to stable methyl adducts for detection, which adds another layer of complexity to identifying the origins of these adducts. In this study, highly sensitive mass spectrometry methods and isotope labeled compounds were used to differentiate between endogenous and exogenous hydroxymethyl and methyl DNA adducts. We demonstrate that N2-hydroxymethyl-dG is the primary DNA adduct formed in cells following formaldehyde exposure. In addition, we show that alkylating agents induce methyl adducts at N2-dG and N6-dA positions, which are identical to the reduced forms of hydroxymethyl adducts arising from formaldehyde. The use of highly sensitive LC-MS/MS and isotope labeled compounds for exposure solves these challenges and provides mechanistic insights on the formation and role of these DNA adducts.
Charge-conjugation symmetric complete impulse approximation for the pion electromagnetic form factor in the Covariant Spectator Theory
Creators: name: Biernat, Elmar P.
name: Gross, Franz
name: Peña, M. T.
name: Stadler, Alfred
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The pion form factor is calculated in the framework of the charge-conjugation invariant Covariant Spectator Theory. This formalism is established in Minkowski space and the calculation is set up in momentum space. In a previous calculation we included only the leading pole coming from the spectator quark (referred to as the relativistic impulse approximation). In this paper we also include the contributions from the poles of the quark which interacts with the photon and average over all poles in both the upper and lower half planes in order to preserve charge conjugation invariance (referred to as the $C$-symmetric complete impulse approximation). We find that for small pion mass these contributions are significant at all values of the four-momentum transfer $Q^2$ but, surprisingly, do not alter the shape obtained from the spectator poles alone.
description: 14 pages, 6 figures; some typos corrected; version published in Phys. Rev. D
Dosimetry of N 6 -Formyllysine Adducts Following [ 13 C 2 H 2 ]-Formaldehyde Exposures in Rats
Creators: name: Swenberg, James A.
name: Doyle-Eisele, Melanie
name: Dedon, Peter C.
name: Moeller, Benjamin C.
name: Taghizadeh, Koli
name: Edrissi, Bahar
name: Kracko, Dean
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: With formaldehyde as the major source of endogenous N6-formyllysine protein adducts, we quantified endogenous and exogenous N6-formyllysine in the nasal epithelium of rats exposed by inhalation to 0.7, 2, 5.8, and 9.1 ppm [13C2H2]-formaldehyde using liquid chromatography-coupled tandem mass spectrometry. Exogenous N6-formyllysine was detected in the nasal epithelium, with concentration-dependent formation in total as well as fractionated (cytoplasmic, membrane, nuclear) proteins, but was not detected in the lung, liver, or bone marrow. Endogenous adducts dominated at all exposure conditions, with a 6 h 9.1 ppm formaldehyde exposure resulting in one-third of the total load of N6-formyllysine being derived from exogenous sources. The results parallel previous studies of formaldehyde-induced DNA adducts.
Gut Microbiome Perturbations Induced by Bacterial Infection Affect Arsenic Biotransformation
Creators: name: Tannenbaum, Steven R.
name: Swenberg, James A.
name: Graffam, Michelle E.
name: Levine, Stuart
name: Fox, James G.
name: Lu, Kun
name: Styblo, Miroslav
name: Bodnar, Wanda M.
name: Schlieper, Katherine Ann
name: Cable, Peter Hans
name: Abo, Ryan Phillip
name: Ru, Hongyu
name: Wishnok, John S.
name: Parry, Nicola M.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Exposure to arsenic affects large human populations worldwide, and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders. In addition, there are large individual differences in susceptibility to arsenic-induced diseases, which are frequently associated with different patterns of arsenic metabolism. Several underlying mechanisms, such as genetic polymorphisms and epigenetics, have been proposed, as these factors closely impact the individuals' capacity to metabolize arsenic. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that perturbations of the gut microbial communities affect the spectrum of metabolized arsenic species and subsequent toxicological effects. In this study, we used an animal model with altered gut microbiome induced by bacterial infection, 16S rRNA gene sequencing and inductively coupled plasma mass spectrometry (ICP-MS)-based arsenic speciation to examine the effect of gut microbiome perturbations on the biotransformation of arsenic. Metagenomics sequencing revealed that bacterial infection significantly perturbed the gut microbiome composition in C57BL/6 mice, which in turn resulted in altered spectra of arsenic metabolites in urine, with inorganic arsenic species, methylated and thiolated arsenic being perturbed. These data clearly illustrated that gut microbiome phenotypes significantly affected arsenic metabolic reactions, including reduction, methylation and thiolation. These findings improve our understanding of how infectious diseases and environmental exposure interact, and may also provide novel insight regarding the gut microbiome composition as a new risk factor of individual susceptibility to environmental chemicals.
title: Influence of Deep Learning Image Reconstruction (DLIR) and Adaptive Statistical Iterative Reconstruction-V (ASIR-V) on Coronary Artery Calcium (CAC) Quantification
Creators: name: Wang, Yiran
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT
subject: Comparative studies
subject: Arteriosclerosis

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Deep learning image reconstruction (DLIR) and adaptive statistical iterative reconstruction-V (ASIR-V) has been used for cardiac computed tomography imaging. However, DLIR and ASIR-V may influence the quantification of coronary artery calcification...
(401444) James Young
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Evaluation of the patient exposure dose during ERCP Fluoroscopy guided procedures
Creators: name: Lesyuk, Oksana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radioprotection / Radiation dose
subject: Fluoroscopy
subject: Cholangiography
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Endoscopic retrograde cholangiopancreatography (ERCP) is a diagnostic/therapeutic fluoroscopy guided procedure that includes upper gastrointestinal endoscopy allowing the treatment of the bile and pancreatic ducts pathologies. Currently, ERCP is...
title: Basic Features Of Condylar Hyperplasia For The General Radiologist
Creators: name: López-Arcas Calleja, José María
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Head and neck
subject: Nuclear medicine
subject: CT
subject: Digital radiography
subject: SPECT-CT
subject: Computer Applications-3D
subject: Computer Applications-Detection, diagnosis
subject: Developmental disease
subject: Hyperplasia / Hypertrophy

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: [mediafile]909994[/mediafile] LEARNING OBJECTIVE 1.To review and illustrate the pathogenesis of idiopathic condylar hyperplasia of the mandible. 2.To present a series of representative cases of idiopathic condylar hyperplasia of the mandible 3.To...
Electrically Engineered Band Gap in Two-Dimensional Ge, Sn, and Pb: A First-Principles and Tight-Binding Approach
Creators: name: Kaloni, Thaneshwor P.
name: Modarresi, Mohsen
name: Tahir, Muhammad
name: Roknabadi, Mahmood Rezaee
name: Schreckenbach, Georg
name: Freund, Michael S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: First-principles calculations were performed to investigate the electronic structure of two-dimensional (2-D) Ge, Sn, and Pb without and with the presence of an external electric field in combination with spin-orbit coupling. Tight-binding calculations based on four orbitals per atom and an effective single orbital are presented to match with the results obtained from first-principles calculations. In particular, the electronic band structure and the band splitting are investigated with both models. Moreover, the simple $k\cdot p$ model is also considered in order to understand the band splitting in the presence of an external electric field and spin-orbit coupling. A large splitting is obtained, which is expected to be useful for spintronic devices. The fair agreement between the first-principle, $k\cdot p$ model, and tight-binding approaches leads to a table of parameters for future tight-binding studies on hexagonal 2-D nanostructures. By using the tight binding parameters, the transport properties of typical 0-D triangular quantum dots between two semi-infinite electrodes in the presence of spin-orbit coupling are addressed.
description: 23 pages, 6 figures, and 3 tables
(401445) Christian Duncan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrative Chemical–Biological Read-Across Approach for Chemical Hazard Classification
Creators: name: Low, Yen
name: Rusyn, Ivan
name: Golbraikh, Alexander
name: Tropsha, Alexander
name: Fourches, Denis
name: Sedykh, Alexander
name: Whelan, Maurice
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Traditional read-across approaches typically rely on the chemical similarity principle to predict chemical toxicity; however, the accuracy of such predictions is often inadequate due to the underlying complex mechanisms of toxicity. Here we report on the development of a hazard classification and visualization method that draws upon both chemical structural similarity and comparisons of biological responses to chemicals measured in multiple short-term assays (”biological” similarity). The Chemical-Biological Read-Across (CBRA) approach infers each compound's toxicity from those of both chemical and biological analogs whose similarities are determined by the Tanimoto coefficient. Classification accuracy of CBRA was compared to that of classical RA and other methods using chemical descriptors alone, or in combination with biological data. Different types of adverse effects (hepatotoxicity, hepatocarcinogenicity, mutagenicity, and acute lethality) were classified using several biological data types (gene expression profiling and cytotoxicity screening). CBRA-based hazard classification exhibited consistently high external classification accuracy and applicability to diverse chemicals. Transparency of the CBRA approach is aided by the use of radial plots that show the relative contribution of analogous chemical and biological neighbors. Identification of both chemical and biological features that give rise to the high accuracy of CBRA-based toxicity prediction facilitates mechanistic interpretation of the models.
Validación experimental de un nuevo útil anti-pandeo para ensayos de compresión post-impacto
Creators: name: F. Simón
name: P. Luna
name: K. Muñoz
name: R. Ocaña
name: L. Vicente
name: M. Jiménez
name: J. Toral
name: R. Olmo
Publisher: name: Zenodo
Year: 2022

description: El ensayo de compresión post-impacto (CAI, por sus siglas en inglés) es empleado normalmente para la determinación de la tolerancia al daño que presentan los laminados de material compuesto tras haber sido impactados. La especificación bajo la que se recoge este ensayo es la AITM 1-0010, sin embargo, para espesores inferiores a 4mm donde se produce aparición de pandeo, la normativa aplicable es la AITM 1-0077, que introduce el uso de un utillaje antipandeo recubriendo la totalidad de la superficie.El útil usado por la industria aeronáutica para realizar el ensayo en estos especímenes presenta dos problemas, la dificultad en su instalación y obtención de resultados fiablesy la visibilidad del especimen durante el ensayo. Este trabajo comprende el diseño, la fabricación y la validación de un nuevo útil antipandeo para el ensayo de compresión post-impacto de especímenes de espesor fino. Para ello, se ha realizado el estudio de los útiles propuestos por las especificaciones aplicables y se ha llevado a cabo una revisión bibliografica de las propuestas de útiles ya desarrollados. Como parte de la validación se han ensayado tres series de especímenes de espesor 3 mm previamente impactados. Esta actividad se engloba dentro del proyecto CERES, desarrollado en el marco de Clean Sky 2, y tiene el objetivo de validar el útil anti-pandeo fabricado, como solución innovadora para su aplicación en los ensayos de compresión post-impacto de especímenes finos.
Spiral magnetic phases on the Kondo Lattice Model: A Hartree-Fock approach
Creators: name: Costa, Natanael de Carvalho
name: de Lima, José Pimentel
name: Santos, Raimundo R. dos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the Kondo Lattice Model (KLM) on a square lattice through a Hartree-Fock approximation in which the local spins are treated semi-classically, in the sense that their average values are modulated by a magnetic wavevector $\mathbf{Q}$ while they couple with the conduction electrons through fermion operators. In this way, we obtain a ground state phase diagram in which spiral magnetic phases (in which the wavevector depends on the coupling constants and on the density) interpolate between the low-density ferromagnetic phase and the antiferromagnetic phase at half filling; within small regions of the phase diagram commensurate magnetic phases can coexist with Kondo screening. We have also obtained `Doniach-like' diagrams, showing the effect of temperature on the ground state phases, and established that for some ranges of the model parameters (the exchange coupling and conduction electron density) the magnetic wavevector changes with temperature, either continuously or abruptly (e.g., from spiral to ferromagnetic).
description: 13 pages, 15 figures
Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo
Creators: name: Prigge, Justin R.
name: Chen, Huadong
name: Major, Michael B.
name: Sang, Shengmin
name: Fu, Junsheng
name: Hu, Yuhui
name: Chen, Xiaoxin
name: Schmidt, Edward E.
name: Soroka, Dominique N.
name: Chen, Hao
name: Yan, Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in colon epithelial cells in vitro and in vivo. Following 6S treatment of HCT-116 cells, the intracellular GSH/GSSG ratio was initially diminished but was then elevated above the basal level. Intracellular reactive oxygen species (ROS) correlated inversely with the GSH/GSSG ratio. Further analysis using gene microarray showed that 6S upregulated the expression of Nrf2 target genes (AKR1B10, FTL, GGTLA4, and HMOX1) in HCT-116 cells. Western blotting confirmed upregulation, phosphorylation, and nuclear translocation of Nrf2 protein followed by Keap1 decrease and upregulation of Nrf2 target genes (AKR1B10, FTL, GGTLA4, HMOX1, and MT1) and glutathione synthesis genes (GCLC and GCLM). Pretreatment of cells with a specific inhibitor of p38 (SB202190), PI3K (LY294002), or MEK1 (PD098059) attenuated these effects of 6S. Using ultra-high-performance liquid chromatography–tandem mass spectrometry, we found that 6S modified multiple cysteine residues of Keap1 protein. In vivo 6S treatment induced Nrf2 nuclear translocation and significantly upregulated the expression of MT1, HMOX1, and GCLC in the colon of wild-type mice but not Nrf2–/– mice. Similar to 6S, a cysteine-conjugated metabolite of 6S (M2), which was previously found to be a carrier of 6S in vitro and in vivo, also activated Nrf2. Our data demonstrated that 6S and its cysteine-conjugated metabolite M2 activate Nrf2 in colon epithelial cells in vitro and in vivo through Keap1-dependent and -independent mechanisms.
title: Development of a B1 correction method without additional scanning for VFA T1 mapping
Creators: name: Fukuda, Nagomi
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: MR physics
subject: MR
subject: Physics
subject: Technical aspects
subject: Outcomes

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Quantitative T 1 mapping of magnetic resonance imaging (MRI) uses biomarkers for determining multiple sclerosis, Parkinson’s disease and Alzheimer’s disease [1]. The inversion recovery (IR) method is the golden standard method for T 1 mapping,...
Additional file 3 of Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis
Creators: name: Abate, Semagn Mekonnen
name: Bahiru Mantefardo
name: Bivash Basu
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Cancer
Science Policy

description: Additional file 3: Supplemental Figure 2. Forest plot for the global prevalence of perioperative mortality among surgical patients with COVID-19 by urgency of surgery: The midpoint of each line illustrates the prevalence; the horizontal line indicates the confidence interval, and the diamond shows the pooled prevalence.
Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism
Creators: name: Parry, Nicola M.A.
name: Mahbub, Ridwan
name: Swenberg, James A.
name: Wishnok, John S.
name: Bodnar, Wanda M.
name: Fox, James G.
name: Cable, Peter Hans
name: Styblo, Miroslav
name: Ru, Hongyu
name: Lu, Kun
name: Tannenbaum, Steven R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.
A vanishing diffusion limit in a nonstandard system of phase field equations
Creators: name: Colli, Pierluigi
name: Gilardi, Gianni
name: Krejčí, Pavel
name: Sprekels, Jürgen
Publisher: name: Weierstrass Institute
Year: 2012
Subjects: subject: nonstandard phase field system
subject: nonlinear partial differential equations
subject: asymptotic limit
subject: convergence of solutions
subject: 35K61
subject: 35A05
subject: 35B40
subject: 74A15

description: We are concerned with a nonstandard phase field model of Cahn--Hilliard type. The model, which was introduced by Podio-Guidugli (Ric. Mat. 2006), describes two-species phase segregation and consists of a system of two highly nonlinearly coupled PDEs. It has been recently investigated by Colli, Gilardi, Podio-Guidugli, and Sprekels in a series of papers: see, in particular, SIAM J. Appl. Math. 2011, and Boll. Unione Mat. Ital. 2012. In the latter contribution, the authors can treat the very general case in which the diffusivity coefficient of the parabolic PDE is allowed to depend nonlinearly on both variables. In the same framework, this paper investigates the asymptotic limit of the solutions to the initial-boundary value problems as the diffusion coefficient $sigma$ in the equation governing the evolution of the order parameter tends to zero. We prove that such a limit actually exists and solves the limit problem, which couples a nonlinear PDE of parabolic type with an ODE accounting for the phase dynamics. In the case of a constant diffusivity, we are able to show uniqueness and to improve the regularity of the solution.
Additional file 1 of Bone turnover biomarkers in COPD patients randomized to either a regular or shortened course of corticosteroids: a substudy of the randomized controlled CORTICO-COP trial
Creators: name: Sivapalan, Pradeesh
name: Jørgensen, Niklas R.
name: Mathioudakis, Alexander G.
name: Eklöf, Josefin
name: Lapperre, Therese
name: Ulrik, Charlotte Suppli
name: Andreassen, Helle F.
name: Armbruster, Karin
name: Praleene Sivapalan
name: Janner, Julie
name: Godtfredsen, Nina
name: Weinreich, Ulla M.
name: Nielsen, Thyge L.
name: Seersholm, Niels
name: Wilcke, Torgny
name: Schuetz, Philipp
name: Klausen, Tobias W.
name: Marså, Kristoffer
name: Vestbo, Jørgen
name: Jens-Ulrik Jensen
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Additional file 1.
(401446) Ernest William Roberts
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis
Creators: name: Abate, Semagn Mekonnen
name: Bahiru Mantefardo
name: Bivash Basu
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Cancer
Science Policy

description: Additional file 1: Supplemental Table 1. methodological quality of included studies
Molecular Dosimetry of Endogenous and Exogenous O 6 -Methyl-dG and N7-Methyl-G Adducts Following Low Dose [ D 3 ]-Methylnitrosourea Exposures in Cultured Human Cells
Creators: name: Collins, Leonard B.
name: Swenberg, James A.
name: Zhang, Zhenfa
name: Nakamura, Jun
name: Clement, Jean M.
name: Sharma, Vyom
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: For DNA-reactive chemicals, a low dose linear assessment of cancer risk is the science policy default. In the present study, we quantitated the endogenous and exogenous N7-methyl-G and O6-methyl-dG adducts in human lymphoblastoid cells exposed to low dose [D3]-methylnitrosourea. Endogenous amounts of both adducts remained nearly constant, while the exogenous adducts showed linear dose-responses. The data show that O6-methyl-dG adducts ≥1.8/108 dG correlated with published studies that demonstrated significant increases of mutations under these conditions. The combined results do not support linear extrapolations to zero when data are available for science-based regulations.
Waterpipes and Electronic Cigarettes: Increasing Prevalence and Expanding Science
Creators: name: Eissenberg, Thomas
name: Pepper, Jessica K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The prevalence of noncigarette tobacco product use is on the rise across the globe, especially for waterpipes (also known as hookah, narghile, and shisha) and electronic cigarettes (e-cigarettes). The scientific literature reveals that waterpipe tobacco smoking is associated with exposure to a variety of toxicants that can cause short- and long-term adverse health events. In contrast, there is far less evidence of health harms related to e-cigarette use, although the variety of products in this category makes it difficult to generalize. We searched the PubMed database for all publications on waterpipes and e-cigarettes from January 2000 to March 2014. The number of publications on waterpipes rose in a slow, linear pattern during this time, while the number of publications on e-cigarettes showed exponential growth. The different trends suggest there may be more interest in studying a novel nicotine product (the e-cigarette) over a traditional tobacco product (the waterpipe). We posit that, although the specific research needs for these products are different, public health would be served best by a more equitable research approach. Scientists should continue to devote attention to understanding the unknown long-term health effects of e-cigarettes and their potential to serve as harm reduction or smoking cessation tools while simultaneously investigating how to reduce waterpipe smoking given that it exposes users to toxicants known to cause harm to health. Recent regulatory action in the United States, which proposes to include waterpipes and e-cigarettes under some of the same regulations as tobacco cigarettes, makes such research particularly timely.
Additional file 5 of Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis
Creators: name: Abate, Semagn Mekonnen
name: Bahiru Mantefardo
name: Bivash Basu
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Cancer
Science Policy

description: Additional file 5: Supplemental Figure 4. Forest plot for sub-group analysis of prevalence of perioperative complication among surgical patients with COVID-19 by types of complication: The midpoint of each line illustrates the prevalence; the horizontal line indicates the confidence interval, and the diamond shows the pooled prevalence
title: Interstitial lung disease in sarcoidosis
Creators: name: ZAKARIAA, ILIAS
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Thorax
subject: CT
subject: Computer Applications-General
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describe the protocol of performing a thoracic CT scan for a suspicion of lung diseaseShow the different aspect of interstitial lung disease in sarcoidosisSee the difference of interstial lung disease in sarcoidosis with the other interstitial lung...
(401442) Adelaide Alice Mary Hancock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Multislice imaging contribution for the diagnosis of left ventricle outflow tract obstruction
Creators: name: Affes, Meriem
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT-Angiography
subject: MR
subject: Computer Applications-3D
subject: Cardiac Assist Devices

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Describe the left ventricle outflow tract (LVOT) anatomy on multislice imaging Outline the diagnostic role of CT and MRI in LVOT obstruction Assess the typical imaging findings associated with valvular, subvalvular, and supra-valvular...
(401443) Elizabeth [Hancock]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Magnetism of Ta Dichalcogenide Monolayers Tuned by Strain and Hydrogenation
Creators: name: Manchanda, Priyanka
name: Sharma, Vinit
name: Yu, Hongbin
name: Sellmyer, D. J.
name: Skomski, Ralph
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The effects of strain and hydrogenation on the electronic and magnetic properties of monolayers of Ta based dichalcogenides (TaX2; X = S, Se, Te) are investigated using density-functional theo-ry. We predict a complex scenario of strain-dependent magnetic phase transitions involving par-amagnetic, ferromagnetic, and modulated antiferromagnetic states. Covering one of the two chalcogenide surfaces with hydrogen switches the antiferromagnetic/nonmagnetic TaX2 mono-layers to a semiconductor. Our research opens new pathways towards the manipulation of mag-netic properties for future optoelectronics and spintronics applications.
description: 13 pages, 5 figures
[Johann Caspar Lavater]
Creators: name: Dinkel, Markus
Publisher: name: [s.n.]
Year: 1790
Subjects: Lavater, Johann Caspar1741-1801

description: Ovales Brustbild im Profil nach links
description: M. Dinkel fec. 1790
description: Inschrift handschriftlich in schwarzer Tinte unterhalb des Bildnisses: "Wahrheit suchen in Liebe, nur dies ist Leben des Lebens. L."
description: Signiert unten rechts: "M: Dinkel fec: 1790."
description: Zuschreibung an Markus Dinkel gemäss handschriftlichem Vermerk auf dem Passepartout
description: Gemäss handschriftlichem Vermerk auf dem Passepartout handelt es sich um eine Kopie nach einem Stich von Johann Heinrich Lips, vgl. Signatur: Lavater, Joh. Caspar I, 15 unten
(401439) Susannah Maria Ford [Lindstedt]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Magnetic Seed Localisation - Rose Centre, St George's Hospital
Creators: name: Lother, Dione
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Lymph nodes
subject: Mammography
subject: Ultrasound
subject: Localisation
subject: Cancer
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Assess the clinical efficacy of magnetic seed (magseed) localisation in select population of breast cancer patients eligible for breast conserving surgery. Evaluate technical factors, advantages, pitfalls and complications of magseed localisation....
Additional file 4 of Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis
Creators: name: Abate, Semagn Mekonnen
name: Bahiru Mantefardo
name: Bivash Basu
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Cancer
Science Policy

description: Additional file 4: Supplemental Figure 3. Forest plot for the subgroup analysis of prevalence of perioperative comorbidity among surgical patients with COVID-19 by types of comorbidity: The midpoint of each line illustrates the prevalence; the horizontal line indicates the confidence interval, and the diamond shows the pooled prevalence.
Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer
Creators: name: González-Horta, Maria Del Carmen
name: Smeester, Lisa
name: Del Razo, Luz M.
name: Tilley, Sloane K.
name: Fry, Rebecca C.
name: Kim, William Y.
name: Tulenko, Samantha E.
name: Ballinas-Casarrubias, Lourdes
name: Zhou, Yi Hui
name: Drobná, Zuzana
name: Wright, Fred A.
name: Ray, Paul D.
name: Stýblo, Miroslav
name: Gutiérrez-Torres, Daniela S.
name: Rager, Julia E.
name: Yosim, Andrew
name: Currier, Jenna M.
name: Ishida, María C.
name: Sánchez-Ramírez, Blanca
name: García-Vargas, Gonzalo G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: There is strong epidemiologic evidence linking chronic exposure to inorganic arsenic (iAs) to a myriad of adverse health effects, including cancer of the bladder. The present study set out to identify DNA methylation patterns associated with iAs and its metabolites in exfoliated urothelial cells (EUCs) that originate primarily from the urinary bladder, one of the targets of arsenic (As)-induced carcinogenesis. Genome-wide, gene-specific promoter DNA methylation levels were assessed in EUCs from 46 residents of Chihuahua, Mexico, and the relationship was examined between promoter methylation profiles and the intracellular concentrations of total As (tAs) and As species. A set of 49 differentially methylated genes was identified with increased promoter methylation associated with EUC tAs, iAs, and/or monomethylated As (MMAs) enriched for their roles in metabolic disease and cancer. Notably, no genes had differential methylation associated with EUC dimethylated As (DMAs), suggesting that DMAs may influence DNA methylation-mediated urothelial cell responses to a lesser extent than iAs or MMAs. Further analysis showed that 22 of the 49 As-associated genes (45%) are also differentially methylated in bladder cancer tissue identified using The Cancer Genome Atlas repository. Both the As- and cancer-associated genes are enriched for the binding sites of common transcription factors known to play roles in carcinogenesis, demonstrating a novel potential mechanistic link between iAs exposure and bladder cancer.
(401441) Ann [Ford]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Protein Sulfenylation: A Novel Readout of Environmental Oxidant Stress
Creators: name: Zhang, Zhenfa
name: Bromberg, Philip
name: Simmons, Steven O.
name: Cheng, Wan Yun
name: Lavrich, Katelyn S.
name: Wages, Phillip A.
name: Samet, James M.
name: Corteselli, Elizabeth
name: Gold, Avram
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Oxidative stress is a commonly cited mechanism of toxicity of environmental agents. Ubiquitous environmental chemicals such as the diesel exhaust component 1,2-naphthoquinone (1,2-NQ) induce oxidative stress by redox cycling, which generates hydrogen peroxide (H2O2). Cysteinyl thiolate residues on regulatory proteins are subjected to oxidative modification by H2O2 in physiological contexts and are also toxicological targets of oxidant stress induced by environmental contaminants. We investigated whether exposure to environmentally relevant concentrations of 1,2-NQ can induce H2O2-dependent oxidation of cysteinyl thiols in regulatory proteins as a readout of oxidant stress in human airway epithelial cells. BEAS-2B cells were exposed to 0–1000 μM 1,2-NQ for 0–30 min, and levels of H2O2 were measured by ratiometric spectrofluorometry of HyPer. H2O2-dependent protein sulfenylation was measured using immunohistochemistry, immunoblotting, and isotopic mass spectrometry. Catalase overexpression was used to investigate the relationship between H2O2 generation and protein sulfenylation in cells exposed to 1,2-NQ. Multiple experimental approaches showed that exposure to 1,2-NQ at concentrations as low as 3 μM induces H2O2-dependent protein sulfenylation in BEAS-2B cells. Moreover, the time of onset and duration of 1,2-NQ-induced sulfenylation of the regulatory proteins GAPDH and PTP1B showed significant differences. Oxidative modification of regulatory cysteinyl thiols in human lung cells exposed to relevant concentrations of an ambient air contaminant represents a novel marker of oxidative environmental stress.
(401435) Emma Howes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401437) Alice Maud Mary Fenwick
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Incidental Findings during CT Pulmonary Angiography
Creators: name: Fileva, Nevena
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Oncology
subject: CT-Angiography
subject: Education
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The purpose of our poster is to show the importance of looking for additional pathologies except the thrombus filling defects in the pulmonary vessels which can explain the clinical presentation and the laboratory results of the...
On the number of subgroups of a given exponent in a finite abelian group
Creators: name: Tărnăuceanu, Marius
name: Tóth, László
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: Primary 20K01, Secondary 20K27, 11N37

description: This paper deals with the number of subgroups of a given exponent in a finite abelian group. Explicit formulas are obtained in the case of rank two and rank three abelian groups. An asymptotic formula is also presented.
description: 15 pages, revised
Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling
Creators: name: Coleman, Rosalind A.
name: Mashek, Douglas G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: An overview of TAG metabolism as a dynamic process that allows its lipid participants to play numerous inter-related roles within cells is presented. For most synthetic pathways each step is...
(401438) Bertha Mary Fenwick
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The optimal monoenergetic energy spectral images for head & neck CT angiography using double low contrast agent injection protocol
Creators: name: Tao, lei
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: CT-Angiography
subject: Angioplasty
subject: Artifacts
subject: Cardiac Assist Devices
subject: Oedema

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Vascular diseases of head and neck are one of the diseases that seriously endanger human health, with a high rate of disability and mortality, and about 6 million cases occur globally every year. Stroke can lead to sequelae, such as hemiplegia and...
(401440) Thomas Ford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Analogue algorithm for parallel factorization of an exponential number of large integers II. Optical implementation
Creators: name: Tamma, Vincenzo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report a detailed analysis of the optical realization [1, 3, 2, 4] of the analogue algorithm described in the first paper of this series [5] for the simultaneous factorization of an exponential number of integers. Such an analogue procedure, which scales exponentially in the context of first order interference, opens up the horizon to polynomial scaling by exploiting multi-particle quantum interference.
description: to be published in Quantum Information Processing (QIP)
Pflanzenschutz im Biokernobstanbau
Creators: name: Häseli, Andreas
Publisher: name: Zenodo
Year: 2022
Subjects: Kernobst
Pflanzenschutz
Biologisch
Schweiz
Krankheiten
Schädlinge
Äpfel
Birnen
Quitten
Empfehlungen

description: Das Merkblatt vermittelt die wesentlichen Informationen für die erfolgreiche biologische Regulierung von Krankheiten und Schädlingen im Anbau von Äpfeln, Birnen und Quitten in der Schweiz. Es erläutert im Detail die Regulierungsmöglichkeiten gegen die wichtigsten Erreger, zeigt auf, wann welche Massnahmen im Kulturjahr fällig sind, und gibt einen Überblick über die verfügbaren Mittel und Methoden.