cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
AITANA-MOMO: Aitana-MoMo project results report
Creators: name: ITI, Instituto Tecnológico de Informática
Publisher: name: Zenodo
Year: 2023
Subjects: 2022
artificial intelligence
machine learning
model monitoring
visualization tools
algorithm analysis
AITANAMOMO

description: The use of Artificial Intelligence (AI) and Machine Learning is increasingly present in our daily lives, across all fields and sectors, both industrial and personal. This new revolution, with significant benefits in all areas of our lives, allows us to interact with the devices around us, such as mobile phones or smart home devices, and in the industry, with predictive maintenance mechanisms or digital twins, among many other successful cases of Artificial Intelligence.

AITANA-MoMo project is motivated by the need to control the quality of the models designed by data scientists and MLOps (Machine Learning Operations, a specific DevOps profile for AI) and aims to facilitate the monitoring and maintenance of AI models in production. This is achieved through a set of tools that enable them to identify potential model degradation issues, analyze new datasets, and make the necessary decisions to generate new models that adapt to the new realities of a production environment.

This document presents the results obtained in the AITANA-MOMO project, which is the continuation of the AITANA-MOVEC project and its predecessor AITANA. The overall objective of this project is to develop monitoring tools for models in production that facilitate their maintenance and allow for the detection of quality degradation in the models.

AITANA-MOMO adds new functionalities to monitor models and data. Monitoring is defined as the supervision of the performance of models in production, allowing the detection of the degradation of their quality, due to uncontrolled changes in the training phase. It is important to point out that the degradation of models has a negative impact on the business results obtained. We need monitor the models in order to avoid possible incorrect predictions, due to uncontrolled situations, and to allow developers to make immediate or even automated decisions over the models in production.

 
description: AITANA-MoMo. Project funded by the Valencian Institute of Business Competitiveness (IVACE) and European Union through the European Regional Development Fund (ERDF), within the public grant program adressed to Technological Institutes of the Valencian Community for the development of non-economic R&D projects carried out in cooperation with companies during 2022 with 135.566,10 €. File number: IMDEEA/2022/50
Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein
Creators: name: Chavarria-Smith, Joseph
name: Vance, Russell E.
name: Miao, Edward A.
name: Zak, Daniel E.
name: Rayamajhi, Manira
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The NAIP/NLRC4 inflammasomes activate caspase-1 in response to bacterial type III secretion systems (T3SS). Inadvertent injection of the T3SS rod protein and flagellin into the cytosol are detected through murine NAIP2 and NAIP5/6, respectively. Here, we identify the agonist for the orphan murine NAIP1 receptor as the T3SS needle protein. NAIP1 is poorly expressed in resting mouse bone marrow-derived macrophages (BMMs), however, priming with poly(I:C) induces it, and confers needle protein sensitivity. Further, overexpression of NAIP1 in immortalized BMMs by retroviral transduction enabled needle detection. In contrast, peritoneal cavity macrophages basally express NAIP1 and respond to needle protein robustly independent of priming. Human macrophages are known to only express one NAIP gene, which detects the needle protein, but not rod or flagellin. Thus, murine NAIP1 is functionally analogous to human NAIP.
A surrogate accelerated multicanonical Monte Carlo method for uncertainty quantification
Creators: name: Wu, Keyi
name: Li, Jinglai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Computation (stat.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 65C05, 65C50

description: In this work we consider a class of uncertainty quantification problems where the system performance or reliability is characterized by a scalar parameter $y$. The performance parameter $y$ is random due to the presence of various sources of uncertainty in the system, and our goal is to estimate the probability density function (PDF) of $y$. We propose to use the multicanonical Monte Carlo (MMC) method, a special type of adaptive importance sampling algorithm, to compute the PDF of interest. Moreover, we develop an adaptive algorithm to construct local Gaussian process surrogates to further accelerate the MMC iterations. With numerical examples we demonstrate that the proposed method can achieve several orders of magnitudes of speedup over the standard Monte Carlo method.
Additional file 2 of Conversion of hulled into naked barley by Cas endonuclease-mediated knockout of the NUD gene
Creators: name: Gerasimova, Sophia V.
name: Hertig, Christian
name: Korotkova, Anna M.
name: Kolosovskaya, Ekaterina V.
name: Otto, Ingrid
name: Hiekel, Stefan
name: Kochetov, Alex V.
name: Khlestkina, Elena K.
name: Kumlehn, Jochen
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Supplementary Table S2. Evaluation of protoplast transfection efficiency.
Asymmetric Magnon Excitation by Spontaneous Toroidal Ordering
Creators: name: Hayami, Satoru
name: Kusunose, Hiroaki
name: Motome, Yukitoshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Effects of spontaneous toroidal ordering on magnetic excitation are theoretically investigated for a localized spin model that includes a staggered Dzyaloshinsky-Moriya interaction and anisotropic exchange interactions, which arise from the antisymmetric spin-orbit coupling and the multi-orbital correlation effect. We show that the model exhibits a Neel-type antiferromagnetic order, which simultaneously accompanies a ferroic toroidal order. We find that the occurrence of toroidal order modulates the magnon dispersion in an asymmetric way with respect to the wave number: a toroidal dipole order on the zigzag chain leads to a band-bottom shift, while a toroidal octupole order on the honeycomb lattice gives rise to a valley splitting. These asymmetric magnon excitations could be a source of unusual magnetic responses, such as nonreciprocal magnon transport. A variety of modulations are discussed while changing the lattice and magnetic symmetries. Implications of candidate materials for asymmetric magnon excitations are presented.
description: 4 pages, 5 figures
a/bare finite complements in Southern Italian varieties: mono-clausal or bi-clausal syntax?
Creators: name: Manzini, M. Rita
name: Lorusso, Paolo
name: Savoia, Leonardo M.
Publisher: name: Quaderni di Linguistica e Studi Orientali
Year: 2017

description: In dialects of Apulia, Calabria and Sicily a restricted number of verbs, including ‘stay/be’, ‘go’, ‘come’ and ‘want’ embed finite complements, either bare or introduced by a. One aim of the present work is to make the corpus of data in Manzini and Savoia (2005) accessible in English. The corpus displays a certain amount of microparametric variation, which is also known, in a less complete form, from independently collected data. On the basis of the evidence presented, we will discuss the two major syntactic analyses proposed for this type of sentences. Under the mono-clausal analysis, verbs like ‘stay, ‘go’ etc. are functional heads embedding a lexical predicate (Cardinaletti and Giusti 2001, 2003). The bi-clausal analysis on the contrary treats embedding under ‘stay’, ‘go’ etc. as anormal clausal embedding (Manzini and Savoia 2005). In this article we reiterate that the bi-clausal analysis is not only feasible, but also advantageous, from a morphosyntactic point of view. We conclude by sketching how this analysis can be rendered compatible with the mono-eventive interpretation that at least some of the relevant structures are reported to have.
description: Quaderni di Linguistica e Studi Orientali, Vol. 3 (2017)
(1810) William Brydson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Diet-Induced Obese Mice Exhibit Altered Heterologous Immunity during a Secondary 2009 Pandemic H1N1 Infection
Creators: name: Milner, J. Justin
name: Karlsson, Erik A.
name: Shi, Qing
name: Beck, Melinda A.
name: Sheridan, Patricia A.
name: Schultz-Cherry, Stacey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: During the 2009 pandemic H1N1 (pH1N1) influenza outbreak, obese individuals were at greater risk for morbidity and mortality to pandemic infection. However, the mechanisms contributing to greater infection severity in obese individuals remain unclear. Although most individuals lacked pre-existing, neutralizing antibody protection to the novel pH1N1 virus, heterologous defenses conferred from exposure to circulating strains or vaccination have been shown to impart protection against pH1N1 infection in humans and mice. Because obese humans and mice have impaired memory T-cell and antibody responses following influenza vaccination or infection, we investigated the impact of obesity on heterologous protection to pH1N1 infection using a mouse model of diet-induced obesity. Lean and obese mice were infected with influenza A/PR/8/34 and five weeks later challenged with a lethal dose of heterologous pH1N1 (A/Cal/04/09). Cross-neutralizing antibody protection was absent in this model, but obese mice exhibited a significantly lower level of non-neutralizing, cross-reactive pH1N1 nucleoprotein antibodies following the primary PR/8 infection. Further, obese mice had elevated viral titers, greater lung inflammation, lung damage, and an increased number of cytotoxic memory CD8+ T cells in the lung airways. Although obese mice had more regulatory T cells (Tregs) in the lung airways compared with lean controls during the pH1N1 challenge, Tregs isolated from obese mice were 40% less suppressive than Tregs isolated from lean mice. Taken together, excessive inflammatory responses to pH1N1 infection, potentially due to greater viral burden and impaired Treg function, may be a novel mechanism by which obesity contributes to greater pH1N1 severity.
title: Zur Erinnerung an Kurt Anderes
title: Kurt Anderes, 1914-1984
titleType: AlternativeTitle
title: 2. Mai 1914 - 16. April 1984
titleType: Subtitle
Creators: name: Dieterle, Theodor
name: König, Peter
Publisher: name: [Verlag nicht ermittelbar]
Year: 1984
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Anderes, Kurt
subject: Winterthur

description: Enthält: Abschiedsworte von Herrn Pfarrer Theodor Dieterle, anlässlich der Trauerfeier am 19. April 1984 im Krematorium Rosenberg, Winterthur und einen Nachruf erschienen in den «Semester-Nachrichten» des «Studenten-Gesangsvereins Zürich», verfasst von Herrn Dr. Peter König, Kilchberg.
THE RECOVERY OF CHTHAMALUS STELLATUS FROM THE EFFECTS OF THE SEVERE WINTER OF 1962-63 ON THE SHORES AT PORNIC, FRANCE
Creators: name: BARNES, H.
name: BARNES, Margaret
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: Observations of the shore at Pornic over a period of several years allows an account to be given of the changes in the population of Chthamalus stellatus arising from the marked effects of the severe winter of 1962-63. By the summer of 1965 recovery was virtually complete.
JOHN SKELTON. Tunnyng of Elynour Rummyng. A Sixteenth-Century English Alewife and Her Customers.
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1943

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
Differential T Cell Responses to Residual Viral Antigen Prolong CD4+ T Cell Contraction following the Resolution of Infection
Creators: name: Su, Maureen A.
name: Eam, Boreth
name: Whitton, J. Lindsay
name: Alirezaei, Mehrdad
name: Whitmire, Jason K.
name: Misumi, Ichiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The contraction phase of the T cell response is a poorly understood period after the resolution of infection when virus-specific effector cells decline in number and memory cells emerge with increased frequencies. CD8(+) T cells plummet in number and quickly reach stable levels of memory following acute lymphocytic choriomeningitis virus infection in mice. In contrast, virus-specific CD4(+) T cells gradually decrease in number and reach homeostatic levels only after many weeks. In this study, we provide evidence that MHCII-restricted viral Ag persists during the contraction phase following this prototypical acute virus infection. We evaluated whether the residual Ag affected the cell division and number of virus-specific naive and memory CD4(+) T cells and CD8(+) T cells. We found that naive CD4(+) T cells underwent cell division and accumulated in response to residual viral Ag for >2 mo after the eradication of infectious virus. Surprisingly, memory CD4(+) T cells did not undergo cell division in response to the lingering Ag, despite their heightened capacity to recognize Ag and make cytokine. In contrast to CD4(+) T cells, CD8(+) T cells did not undergo cell division in response to the residual Ag. Thus, CD8(+) T cells ceased division within days after the infection was resolved, indicating that CD8(+) T cell responses are tightly linked to endogenous processing of de novo synthesized virus protein. Our data suggest that residual viral Ag delays the contraction of CD4(+) T cell responses by recruiting new populations of CD4(+) T cells.
Modal particles in Albanian subjunctive, infinitive and supine constructions: presence vs absence of clitic climbing
Creators: name: Turano, Giuseppina
Publisher: name: Quaderni di Linguistica e Studi Orientali
Year: 2017

description: It is a well-known fact that the infinite/subjunctive substitution, attested in Balkan languages, correlates with possibility/impossibility of clitic climbing. Modal particles, which precede subjunctive verbs, have been taken as minimality blockers for clitic movement. Focussing on standard Albanian and Albanian dialects, I will show that the possibility/impossibility of clitic climbing cannot be attributed to the absence/presence of modal particles, since, on the one hand, it is possible to find raising of the clitic in contexts with modal particles, i.e. clitic climbing out of infinitival clauses characterized by the presence of two blocking heads (a preposition and a modal particle) and from supine constructions (preceded by a nominal particle), whereas, on the other hand, clitic climbing is impossible in contexts without modal particles. It seems that, at least in Albanian, the distribution of clitics does not depend on the presence or absence of modal particles, but it is related to the presence or absence of the functional category T. I will assume that clitic movement is the result of two operations: movement to the T head and morphological incorporation (m-merger in Matushansky’s (2006) sense).
description: Quaderni di Linguistica e Studi Orientali, Vol. 3 (2017)
Comment on "Texture Zeros and WB Transformations in the Quark Sector of the Standard Model"
Creators: name: Sharma, Samandeep
name: Fakay, Priyanka
name: Ahuja, Gulsheen
name: Gupta, Manmohan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recently, using specific Weak Basis transformations, Y. Giraldo [Phys. Rev. D 86, 093021 (2012)] has constructed some texture 5 and 4 zero quark mass matrices and examined their compatibility with the quark mixing data. In this comment, we have re-analyzed these to bring forth certain important issues regarding their viability which need to be taken note of.
description: 5 pages, 1 figure, Accepted for publication in PRD
Divergent Effects of T Cell Costimulation and Inflammatory Cytokine Production on Autoimmune Peripheral Neuropathy Provoked by Aire Deficiency
Creators: name: Su, Maureen A.
name: Smith, Colin Jamal
name: Zeng, Xiaopei L.
name: Howard, James F.
name: Nagavalli, Anil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) results from autoimmune destruction of the peripheral nervous system (PNS) and is a component of the multi-organ autoimmunity syndrome which results from Autoimmune Regulator (Aire) gene mutations in humans. In parallel, PNS autoimmunity resembling CIDP develops spontaneously in NOD mice with a partial loss of Aire function (NOD.AireGW/+ mice), and is a T cell-mediated disease. In this study, we analyze how key aspects of T cell activation and function modulate disease development in Aire-deficient mice. We show here that genetic ablation of the Th1 cytokine IFNγ completely prevents clinical and electrophysiological evidence of neuropathy in NOD.AireGW/+ mice. IFNγ deficiency is associated with absence of immune infiltration and decreased expression of the T cell chemoattractant IP-10 in sciatic nerves. Thus, IFNγ is absolutely required for the development of autoimmune peripheral neuropathy in NOD.AireGW/+ mice. Because IFNγ secretion is enhanced by B7-CD28 costimulation of T cells, we sought to determine the effects of these costimulatory molecules on neuropathy development. Surprisingly, B7-2 deficiency accelerated neuropathy development in NOD.AireGW/+ mice, and antibody blockade of both B7-1 and B7-2 resulted in fulminant, early-onset neuropathy. Thus, in contrast to IFNγ, B7-2 alone and B7-1/B7-2 in combination function to ameliorate neuropathy development in NOD.AireGW/+ mice. Together, these findings reveal distinct and opposing effects of T cell costimulatory pathways and IFNγ production on the pathogenesis of autoimmune peripheral neuropathy.
(1811) Gens Brydson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Fibrin Facilitates Both Innate and T Cell-Mediated Defense against Yersinia pestis
Creators: name: Szaba, Frank M.
name: Lin, Jr Shiuan
name: Mullarky-Kanevsky, Isis
name: Smiley, Stephen T.
name: Gruber, Andras
name: Parent, Michelle A.
name: Gailani, David
name: Kummer, Lawrence W.
name: Mackman, Nigel
name: Duso, Debra K.
name: Tighe, Michael
name: Luo, Deyan
name: Hill, Jim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The gram-negative bacterium Yersinia pestis causes plague, a rapidly progressing and often fatal disease. The formation of fibrin at sites of Y. pestis infection supports innate host defense against plague, perhaps by providing a non-diffusible spatial cue that promotes the accumulation of inflammatory cells expressing fibrin-binding integrins. This report demonstrates that fibrin is an essential component of T cell-mediated defense against plague but can be dispensable for antibody-mediated defense. Genetic or pharmacologic depletion of fibrin abrogated innate and T cell-mediated defense in mice challenged intranasally with Y. pestis. The fibrin-deficient mice displayed reduced survival, increased bacterial burden, and exacerbated hemorrhagic pathology. They also showed fewer neutrophils within infected lung tissue and reduced neutrophil viability at sites of liver infection. Depletion of neutrophils from wild type mice weakened T cell-mediated defense against plague. The data suggest that T cells combat plague in conjunction with neutrophils, which require help from fibrin in order to withstand Y. pestis encounters and effectively clear bacteria.
Some notes on Italian ethnic adjectives
Creators: name: Franco, Ludovico
Publisher: name: Quaderni di Linguistica e Studi Orientali
Year: 2017

description: In this paper, we deal with ethnic adjectives in Italian, arguing against the dichotomy between ‘thematic’ and ‘classificatory’ ethnic adjectives, recently assumed by Alexiadou and Stavrou (2011). Building on Manzini and Savoia (2011), Manzini and Franco (2016), Franco and Manzini (2017), Savoia et al. (2017, forthcoming), we provide a unified characterization of Italian ethnic adjectives and we take the derivational morphemes shaping this kind of items to be a derivational counterpart of the genitive adposition di (of) (and other kinds of obliques), sharing with the latter a common predicational core and a common signature. The proposal advanced for ethnic adjectives can be broadly extended to relational adjectives in general.
description: Quaderni di Linguistica e Studi Orientali, Vol. 3 (2017)
Development of para-amino salicylic acid minitablets for controlled release drug delivery
Creators: name: Wannisa Srichamnong
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2010
Subjects: Multiple unit dosage forms, Enteric coating, Para-amiosalicylic acid (PAS), Minitablets

description: Isan Journal ofPharmaceutical Sciences, 6, 2, 67-73
Changing the topic in question-answer pairs: a production study on the use of subject, topicalization and passive in Italian
Creators: name: Manetti, Claudia
Publisher: name: Quaderni di Linguistica e Studi Orientali
Year: 2017

description: The present study deals with the production of discourse-related structures, and in particular it focuses on the use of (lexical vs null) subjects, topicalized structures with clitic pronouns (e.g. Subject-Cl-Verb) and passives in Italian-speaking children (aged from 4- to 9-year-old), as well as in adults. Three eliciting questions, associated with transitive actions, manipulated the discourse context by asking to talk about the agent, the patient or elicited an all-new description of the event. The production task enabled us to investigate the use of null vs overt lexical subjects, by contrasting the conditions in which the subject was new or given information in the question; second, we examined the way children and adults topicalize the patient. Results showed that both children and adults preferred the use of null subjects when the subject was given in the question, whereas they both opted for a lexical preverbal subject when it was new information. Children and adults, instead, sharply differed in the way they topicalized the patient: all children, also in the oldest group, preferred the use of topicalized structures with an active verb and a clitic pronoun referring to the topic patient; adults instead overwhelmingly opted for the passive. These results showed that the avoidance of passive in this specific eliciting context persisted even at a later stage in development.
description: Quaderni di Linguistica e Studi Orientali, Vol. 3 (2017)
Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN- +CD4+ T Cell Numbers during Colitis Development in Mice
Creators: name: Tedder, Thomas F.
name: Kalampokis, Ioannis
name: Weaver, Casey T.
name: Maseda, Damian
name: Poe, Jonathan C.
name: Candando, Kathleen M.
name: Plevy, Scott E.
name: Smith, Susan H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells) modulates both immune responses and autoimmune disease severity. However, the peritoneal cavity also contains relatively high frequencies of functionally-defined IL-10-competent B10 cells. In this study, peritoneal cavity B10 cells shared similar cell surface phenotypes with their spleen counterparts. However, peritoneal cavity B10 cells were 10-fold more frequent among B cells than occurred within the spleen, intestinal track or mesenteric lymph nodes and were present at higher proportions among the phenotypically-defined peritoneal B1a>B1b>B2 cell subpopulations. The development or localization of B10 cells within the peritoneal cavity was not dependent on the presence of commensal microbiota, T cells, IL-10 or B10 cell IL-10 production, or differences between their fetal liver or adult bone marrow progenitor cell origins. The BCR repertoire of peritoneal cavity B10 cells was diverse, as occurs in the spleen, and predominantly included germline-encoded VH and VL regions commonly found in either the conventional or B1 B cell compartments. Thereby, the capacity to produce IL-10 appears to be an intrinsic functional property acquired by clonally diverse B cells. Importantly, IL-10 production by peritoneal cavity B cells significantly reduced disease severity in spontaneous and induced models of colitis by regulating neutrophil infiltration, colitogenic CD4+ T cell activation and pro-inflammatory cytokine production during colitis onset. Thus, the numerically small B10 cell subset within the peritoneal cavity has regulatory function and is important for maintaining homeostasis within gastrointestinal tissues and the immune system.
GÉNÉTIQUE DES POPULATIONS DE SPHAEROMA SERRATUM (F.). Vili.  NOUVELLES OBSERVATIONS SUR LA STABILITÉ DU POLYCHROMATISME LOCAL
Creators: name: GOUDEAU, Marie
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: Investigations on the distribution of diverse types of coloration of Sphaeroma serratum, along the coast of Bretagne, involved the study of twenty populations. Five of them have been again analysed ten years after, showing a remarkable stability of the  genetic structures. New samples taken in 1964-1965 from fifteen populations, reinforce the notion of an exceptional stability of the local polychromatism.
Phosphatidylinositol 3-Kinase-  Signaling Promotes Campylobacter jejuni-Induced Colitis through Neutrophil Recruitment in Mice
Creators: name: Jobin, Christian
name: Sartor, Ryan Balfour
name: Liu, Bo
name: Sun, Xiaolun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Crypt abscesses caused by excessive neutrophil accumulation are prominent features of human campylobacteriosis and its associated pathology. The molecular and cellular events responsible for this pathological situation are currently unknown. We investigated the contribution of PI3Kγ signaling in Campylobacter jejuni-induced neutrophil accumulation and intestinal inflammation. Germ-free and specific pathogen free Il10−/−and germ-free Il10−/−; Rag2−/− mice were infected with C. jejuni (109 CFU/mouse). PI3Kγ signaling was manipulated using either the pharmacological PI3Kγ inhibitor AS252424 (i.p. 10 mg/kg daily) or genetically using Pi3γ−/− mice. After up to 14 days, inflammation was assessed histologically and by measuring levels of colonic Il1β, Cxcl2 and Il17a mRNA. Neutrophils were depleted using anti-Gr1 antibody (i.p. 0.5 mg/mouse/every 3 days). Using germ-free Il10−/−; Rag2−/− mice, we observed that innate immune cells are the main cellular compartment responsible for campylobacteriosis. Pharmacological blockade of PI3Kγ signaling diminished C. jejuni-induced intestinal inflammation, neutrophil accumulation and NF-κB activity, which correlated with reduced Il1β (77%), Cxcl2 (73%) and Il17a (72%) mRNA accumulation. Moreover, Pi3kγ−/− mice pretreated with anti-IL-10R were resistant to C. jejuni-induced intestinal inflammation compared to Wt mice. This improvement was accompanied by a reduction of C. jejuni translocation into the colon and extra-intestinal tissues and by attenuation of neutrophil migratory capacity. Furthermore, neutrophil depletion attenuated C. jejuni-induced crypt abscesses and intestinal inflammation. Our findings indicate that C. jejuni-induced PI3Kγ signaling mediates neutrophil recruitment and intestinal inflammation in Il10−/− mice. Selective pharmacological inhibition of PI3Kγ may represent a novel means to alleviate severe cases of campylobacteriosis, especially in antibiotic-resistant strains.
Additional file 4 of Conversion of hulled into naked barley by Cas endonuclease-mediated knockout of the NUD gene
Creators: name: Gerasimova, Sophia V.
name: Hertig, Christian
name: Korotkova, Anna M.
name: Kolosovskaya, Ekaterina V.
name: Otto, Ingrid
name: Hiekel, Stefan
name: Kochetov, Alex V.
name: Khlestkina, Elena K.
name: Kumlehn, Jochen
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Supplementary Table S4. Target mutations in T0 and T1 detected in selected plants.
DER FREUDENLEERE. Wiener Mervrat. (A German Poem of the Thirteenth Century. Comments and Prose Translation by E. M. Jellinek.)
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1945

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
Branching onsets and segment licensing: the lack of debuccalization or deletion of the muta cum liquida clusters in central Sardinian dialects
Creators: name: Molinu, Lucia
Publisher: name: Quaderni di Linguistica e Studi Orientali
Year: 2017

description: Some central Sardinian dialects undergo debuccalization of /f/ and /k/. The clusters /fr/ and /kr/, on the other hand, fail to undergo debuccalization or deletion (Wagner 1984 [1941]; Contini 1987; Molinu 1997). The purpose of this article is to attempt to answer the following questions: why does debuccalization of /f/ and /k/ or /f/ deletion systematically affect the fricative in a simple onset but not when /f/ and /k/ are in a branching onset? Which syllabic and segmental requirements determine the different outcomes of /f/ and /k/? I will focus on Rice’s model (Avery and Rice 1989; Rice and Avery 1991; Rice 1992, 1993, 1994a, 1994b) which makes use of the representation of segments to account for their licensing in a syllabic constituent. Indeed Rice assumes two principles (government and binding) which license the consonants in tautosyllabic or heterosyllabic sequences in structural terms, i.e. on the basis of the segment structure. I will account for the absence of debuccalization in the /fr/ and /kr/ clusters showing that the debuccalization process is blocked or repaired when it violates a principle on the structural relationships that hold within segments of branching onsets.
description: Quaderni di Linguistica e Studi Orientali, Vol. 3 (2017)
(1813) Jane Campbell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 5 of Conversion of hulled into naked barley by Cas endonuclease-mediated knockout of the NUD gene
Creators: name: Gerasimova, Sophia V.
name: Hertig, Christian
name: Korotkova, Anna M.
name: Kolosovskaya, Ekaterina V.
name: Otto, Ingrid
name: Hiekel, Stefan
name: Kochetov, Alex V.
name: Khlestkina, Elena K.
name: Kumlehn, Jochen
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Supplementary Table S5. List of primers and oligonucleotides used in this study.
The voiced and voiceless outcomes of intervocalic -SJ- in Old Tuscan
Creators: name: Canalis, Stefano
Publisher: name: Quaderni di Linguistica e Studi Orientali
Year: 2017

description: This paper deals with the non-systematic voicing of intervocalic sj in Old Tuscan. Old Tuscan displays both voiceless [ʃ] and voiced [ʒ] as outcomes of intervocalic sj, without an obvious phonological conditioning determining them. None of the existing attempts to account for this dual outcome – the search for a Neogrammarian regularity, the supposed introduction of [ʒ] through lexical borrowing, the hypothesis of a variable sound change – is completely satisfactory. It will be proposed that the hypothesis of a variable result of this sound change can be theoretically refined and given new empirical arguments. Specifically, it will be argued that an allophonic voicing rule may be followed by a partial lexical re-categorization of its output, and it will be shown that the outcome [ʒ] is most likely when the following vowel is low and/or stressed.
description: Quaderni di Linguistica e Studi Orientali, Vol. 3 (2017)
Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors
Creators: name: Ellermann-Eriksen, Svend
name: Kurt-Jones, Evelyn
name: Melchjorsen, Jesper
name: Iversen, Marie B.
name: Horan, Kristy A.
name: Hansen, Kathrine
name: Holm, Christian K.
name: Damania, Blossom
name: Unterholzner, Leonie
name: Paludan, Søren R.
name: Landolfo, Santo
name: Bowie, Andrew G.
name: Rasmussen, Simon B.
name: Jakobsen, Martin R.
name: Thompson, Mikayla
name: Fitzgerald, Katherine A.
name: Søby, Stine
name: West, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The innate immune system is important for control of infections, including herpesvirus infections. Intracellular DNA potently stimulates antiviral IFN responses. It is known that plasmacytoid dendritic cells sense herpesvirus DNA in endosomes via TLR9, and that non-immune tissue cells can sense herpesvirus DNA in the nucleus. However, it remains unknown how and where myeloid cells, like macrophages and conventional dendritic cells, detect infections with herpesviruses. Here we demonstrate that the HSV-1 capsid was ubiquitinated in the cytosol and degraded by the proteasome, hence releasing genomic DNA into the cytoplasm for detection by DNA sensors. In this context, the DNA sensor IFI16 is important for induction of IFN-β in human macrophages after infection with HSV-1 and CMV. Viral DNA localized to the same cytoplasmic regions as IFI16, with DNA sensing being independent of viral nuclear entry. Thus, proteasomal degradation of herpesvirus capsids releases DNA to the cytoplasm for recognition by DNA sensors.
Regulatory B Cell (B10 Cell) Expansion during Listeria Infection Governs Innate and Cellular Immune Responses in Mice
Creators: name: Weimer, Eric T.
name: DiLillo, David J.
name: Spolski, Rosanne
name: Horikawa, Mayuka
name: Tedder, Thomas F.
name: Heise, Mark T.
name: Leonard, Warren J.
name: Venturi, Guglielmo M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Pathogens use numerous methods to subvert host immune responses, including the modulation of host IL-10 production by diverse cell types. However, the B cell sources of IL-10 and their overall influence on innate and cellular immune responses have not been well characterized during infections. Using Listeria as a model pathogen, infection drove the acute expansion of a small subset of regulatory B cells (B10 cells) that potently suppress inflammation and autoimmunity through the production of IL-10. Unexpectedly, spleen bacteria loads were 92–97% lower in B10 cell-deficient CD19−/− mice, in mice depleted of mature B cells, and in mice treated with CD22 mAb to preferentially deplete B10 cells before infection. By contrast, the adoptive transfer of wild type B10 cells reduced bacterial clearance by 38-fold in CD19−/− mice through IL-10-dependent pathways. B10 cell depletion using CD22 mAb significantly enhanced macrophage phagocytosis of Listeria and their production of IFN-γ, TNF-α, and nitric oxide ex vivo. Accelerated bacteria clearance following B10 cell depletion significantly reduced Ag-specific CD4+ T cell proliferation and cytokine production, but did not alter CD8+ T cell responses. B10 cell regulatory function during innate immune responses was nonetheless dependent on cognate interactions with CD4+ T cells since B10 cells deficient in IL-10, MHC-II or IL-21 receptor expression did not influence Listeria clearance. Thus, Listeria manipulates immune responses through a strategy of immune evasion that involves the preferential expansion of endogenous B10 cells that regulate the magnitude and duration of both innate and cellular immune responses.
Redescription, morphology, and biogeography of Centroderes spinosus (Reinhard, 1881) (Kinorhyncha, Cyclorhagida) from Europe
Creators: name: NEUHAUS, Birger
name: PARDOS, Fernando
name: SØRENSEN, Martin V.
name: HIGGINS, Robert P.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The taxonomic status of the kinorhynch genus Centroderes has been obscure in terms of definition and relationships since the genus was proposed by Zelinka in 1907. To solve the taxonomic confusion, the genus' type species Centroderes spinosus (Reinhard, 1881) is redescribed by both light microscopy (based on 102 adult and 7 juvenile specimens) and SEM (based on 18 adult and 2 juvenile specimens). The species was collected near its type locality in the Black Sea as well as at several other European sites in Croatia, Spain, Ireland and Sweden. The study reveals that the two known species of the genus, C. spinosus and C. eisigii Zelinka, 1928 represent male and female of C. spinosus comb. nov. with gender-specific morphological differences. Therefore, C. eisigii is suggested as a junior synonym of C. spinosus. Campyloderes adherens Nyholm, 1947 is synonomized with Centroderes spinosus comb. nov. (Reinhard, 1881). The study also shows that the life history of cyclorhagid Kinorhyncha may have to be rewritten, because evidence is presented here that adult specimens undergo a moult to a second adult stage. For C. spinosus comb. nov. additional morphological and nutritional aspects are provided.
Observations of Type Ia Supernova 2014J with FLITECAM/SOFIA
Creators: name: Vacca, William D.
name: Hamilton, Ryan T.
name: Savage, Maureen
name: Shenoy, Sachindev
name: Becklin, E. E.
name: McLean, Ian S.
name: Logsdon, Sarah E.
name: Gehrz, R. D.
name: Spyromilio, J.
name: Garnavich, P.
name: Marion, G. H.
name: Fox, O. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present medium resolution near-infrared (NIR) spectra, covering 1.1 to 3.4 microns, of the normal Type Ia supernova (SN Ia) SN 2014J in M82 obtained with the FLITECAM instrument aboard SOFIA approximately 17-25 days after maximum B light. Our 2.8-3.4 micron spectra may be the first ~3 micron spectra of a SN Ia ever published. The spectra spanning the 1.5-2.7 micron range are characterized by a strong emission feature at ~1.77 microns with a full width at half maximum of ~11,000-13,000 km/s. We compare the observed FLITECAM spectra to the recent non-LTE delayed detonation models of Dessart et al. (2014) and find that the models agree with the spectra remarkably well in the 1.5-2.7 micron wavelength range. Based on this comparison we identify the ~1.77 micron emission peak as a blend of permitted lines of Co II. Other features seen in the 2.0 - 2.5 micron spectra are also identified as emission from permitted transitions of Co II. However, the models are not as successful at reproducing the spectra in the 1.1 - 1.4 micron range or between 2.8 and 3.4 microns. These observations demonstrate the promise of SOFIA by allowing access to wavelength regions inaccessible from the ground, and serve to draw attention to the usefulness of the regions between the standard ground-based NIR passbands for constraining SN models.
description: 23 pages, including 7 figures; Accepted by ApJ
The Depletion of NK Cells Prevents T Cell Exhaustion to Efficiently Control Disseminating Virus Infection
Creators: name: Whitmire, Jason K.
name: Cook, Kevin D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: NK cells have well-established functions in immune defense against virus infections and cancer through their cytolytic activity and production of cytokines. In this study, we examined the frequency of NK cells and their influence on T cell responses in mice given variants of lymphocytic choriomeningitis virus that cause acute or persisting infection. We found increased frequencies of circulating NK cells during disseminating infection compared with uninfected or acutely infected mice. Consistent with recent reports, we observed that the depletion of NK cells in mice with disseminated infection increased peak numbers of virus-specific cytokine producing CD8(+) T cells and resulted in the rapid resolution of disseminated infection. Additionally, we show that NK cell depletion sustained T cell responses across time and protected against T cell exhaustion. The positive effects of NK cell depletion on T cell responses only occurred when NK cells were depleted within the first 2 d of infection. We find that the improved CD8(+) T cell response correlated with an enhanced ability of APCs from NK cell-depleted mice to stimulate T cell proliferation, independently of the effects of NK cells on CD4(+) T cells. These results indicate that NK cells play an integral role in limiting the CD8 T cell response and contribute to T cell exhaustion by diminishing APC function during persisting virus infection.
Interfacial Effects on the Optical Properties of CdTe/CdS Quantum Dots
Creators: name: Gaur, Girija
name: Koktysh, Dmitry S.
name: Fleetwood, Daniel M.
name: Weller, Robert A.
name: Reed, Robert A.
name: Weiss, Sharon M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Using a combination of continuous wave and time-resolved spectroscopy, we study the effects of interfacial conditions on the radiative lifetimes and photoluminescence intensities of colloidal CdTe/CdS quantum dots (QDs) embedded in a three-dimensional nanostructured silicon (NSi) matrix. The NSi matrix was thermally oxidized under different conditions to change the interfacial oxide thickness. QDs embedded in a NSi matrix with ~0.5 nm of interfacial oxide exhibited reduced photoluminescence intensity and nearly five times shorter radiative lifetimes (~16 ns) compared to QDs immobilized within completely oxidized, nanostructured silica (NSiO2) frameworks (~78 ns). Optical absorption by the sub-nm oxidized NSi matrix partially lowers QD emission intensities while non-radiative carrier recombination and phonon assisted transitions influenced by defect sites within the oxide and NSi are believed to be the primary factors limiting the QD exciton lifetimes in the heterostructures.
On the Tradeoff between Energy Harvesting and Caching in Wireless Networks
Creators: name: Kumar, Akshay
name: Saad, Walid
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Self-powered, energy harvesting small cell base stations (SBS) are expected to be an integral part of next-generation wireless networks. However, due to uncertainties in harvested energy, it is necessary to adopt energy efficient power control schemes to reduce an SBSs' energy consumption and thus ensure quality-of-service (QoS) for users. Such energy-efficient design can also be done via the use of content caching which reduces the usage of the capacity-limited SBS backhaul. of popular content at SBS can also prove beneficial in this regard by reducing the backhaul usage. In this paper, an online energy efficient power control scheme is developed for an energy harvesting SBS equipped with a wireless backhaul and local storage. In our model, energy arrivals are assumed to be Poisson distributed and the popularity distribution of requested content is modeled using Zipf's law. The power control problem is formulated as a (discounted) infinite horizon dynamic programming problem and solved numerically using the value iteration algorithm. Using simulations, we provide valuable insights on the impact of energy harvesting and caching on the energy and sum-throughput performance of the SBS as the network size is varied. Our results also show that the size of cache and energy harvesting equipment at the SBS can be traded off, while still meeting the desired system performance.
description: To be presented at the IEEE International Conference on Communications (ICC), London, U.K., 2015
(1806) Catherine Ann Crawford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.