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title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of mass-spectrometric techniques for monitoring the composition of gas impurities using a quadrupole spectrometer
Creators: name: Ð§ÐµÑÐµÐ´Ð½Ð¸ÐºÐ¾Ð²Ð°, ÐÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð¼Ð°ÑÑ-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
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ÐºÐ²Ð°Ð´ÑÑÐ¿Ð¾Ð»ÑÐ½ÑÐ¹ Ð¼Ð°ÑÑ-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑ
mass spectrometry
human functional status
clinical diagnosis
acute respiratory viral infections
quadrupole mass spectrometer

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description: This work is devoted to the development of express methods for diagnosis and monitoring of recovery after a respiratory viral infection using a quadrupole mass spectrometer using methods of multivariate statistical analysis of data. In this study we investigated the exhaled air gas composition in two groups of examinees: a group of healthy cadets at the Kirov Saint-Petersburg Military Medical Academy aged from 18 to 21 and a group of people who had had an acute respiratory viral infection. The sample composition was analyzed using a small-size quadrupole mass spectrometer MS7-200 with direct sample introduction at atmospheric pressure, developed at IAP RAS. Sampling was performed in special sampling devices with a capacity of 20 ml. The results of the experimental study showed that the mass spectra of the two groups of subjects had clear differences. Concentration of substances which are part of the exhaled air of a healthy person in a certain ratio, namely acetone, acetic acid and isoprene, was significantly underestimated, also high concentrations of unknown substances were found. The mathematical analysis by method of main components of results of experimental researches, has shown, that the gas composition of the exhaled air of subjects has a tendency to grouping. The results of the study confirm the effectiveness of the proposed mass spectrometric diagnostic technique and show the prospects of its use by medical organizations for diagnosing acute viral respiratory infections and by research laboratories for detecting new biomarkers of various diseases.Â