cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Effect of austenitising temperature on the microstructural evolution of a novel corrosion resistant bearing steel alloy
Creators: name: Faqiri, Y.
name: Hassel, T.
Publisher: name: TU Clausthal
Year: 2025
Subjects: subject: 620

description: The investigation of carbide dissolution as a function of austenitising temperature is a decisive factor for optimizing the heat treatment processes of steels. Therefore, in this study, the kinetics of carbide dissolution at different austenitising temperatures at 880 °C, 1030 °C and 1200 °C for a iron-based alloy were examined. CALPHAD-based computational software JMatPro® was used to determine the targeted austenitising temperatures of the alloy. The alloy was produced by means of Plasma-Transferred-Arc welding and were investigated by microstructural analysis. The results showed that the morphology of the eutectic network depends on the austenitising temperature and holding time. High temperatures resulted in grain growth, irrespective of the holding time applied. With increasing temperature and longer holding times, there was a general dissolution of the elements into the iron matrix. However, excessively long holding times caused an Ostwald ripening effect, which negatively impacted the homogeneity of the microstructure. The results of the study showed that an austenitising temperature of 1030 °C, combined with a holding time of 30 minutes, represented the optimal conditions for both heat treatment and subsequent forming.
description: Tagungsband 6. Symposium Materialtechnik: 20. bis 21. Februar 2025
Generation of engineered innate lymphoid cells for cancer immunotherapy using pluripotent stem cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Tobacco use is the leading cause of several difficult-to-treat cancers in California, most notably lung cancer. Immunotherapy is a new approach to cancer treatment that enhances the body’s immune system to detect and destroy cancer cells. T cells, a type of immune cell, play an important role in the human immune system’s ability to fight cancer and are increasingly being used in cancer immunotherapy. Chimeric antigen receptor (CAR) engineered T cell therapy genetically reprograms a patient’s own T cells to specifically recognize and kill cancer cells. CAR-T cell therapy has led to dramatic clinical responses in B cell leukemia and lymphoma, and is currently under intensive investigation as a treatment for solid tumors, including lung cancer. A new approach to improving CAR-T cell therapy for solid tumors is to use human pluripotent stem cells (hPSCs) to generate optimized immune cells in the lab. hPSCs have the capacity to self-renew in the lab, and therefore can potentially be engineered to produce hPSC-derived immune cells with enhanced activity against certain cancers, and the ability to be used in any patients as “off-the-shelf” cell therapies. Our group has developed a novel culture system called the artificial thymic organoid (ATO) system that supports the generation of functional T cells from hPSCs in the lab. In addition to T cells, however, innate immune cells, including natural killer cells, have shown promise in cancer immunotherapy, with comparable anti-tumor efficacy and less toxicity than T cells in early lab studies. By modifying the ATO system, we have engineered hPSCs with a leukemia-targeting CAR, and induced their differentiation into CAR-expressing innate immune cells. These CAR-engineered cells specifically recognized and killed leukemia cells. The research I propose builds on these findings to use the ATO system to develop and test hPSC-derived CAR-engineered innate immune cells for the treatment of lung cancer. The goal of this project is to establish a platform to generate a novel class of “off-the-shelf” cell products for immunotherapy to treat lung cancer, but also one that can be adapted in the future for the treatment of multiple other tobacco-related cancers.
sj-pdf-1-vas-10.1177_1708538120921735 - Supplemental material for The novel role of IL-37 to enhance the anti-inflammatory response of regulatory T cells in patients with peripheral atherosclerosis
Creators: name: Lotfy, Hassan
name: Moaaz, Marwa
name: Moaaz, Mai
Publisher: name: SAGE Journals
Year: 2020
Subjects: Cardiology

description: Supplemental material, sj-pdf-1-vas-10.1177_1708538120921735 for The novel role of IL-37 to enhance the anti-inflammatory response of regulatory T cells in patients with peripheral atherosclerosis by Hassan Lotfy, Marwa Moaaz and Mai Moaaz in Vascular
sj-pdf-1-pul-10.1177_2045894020919355 - Supplemental material for A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice
Creators: name: Kato, Taichi
name: Mitani, Yoshihide
name: Masuya, Masahiro
name: Maruyama, Junko
name: Sawada, Hirofumi
name: Ohashi, Hiroyuki
name: Ikeyama, Yukiko
name: Otsuki, Shoichiro
name: Yodoya, Noriko
name: Shinohara, Tsutomu
name: Miyata, Eri
name: Erquan Zhang
name: Katayama, Naoyuki
name: Shimpo, Hideto
name: Maruyama, Kazuo
name: Komada, Yoshihiro
name: Hirayama, Masahiro
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Cardiology
subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-pul-10.1177_2045894020919355 for A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice by Taichi Kato, Yoshihide Mitani, Masahiro Masuya, Junko Maruyama, Hirofumi Sawada, Hiroyuki Ohashi, Yukiko Ikeyama, Shoichiro Otsuki, Noriko Yodoya, Tsutomu Shinohara, Eri Miyata, Erquan Zhang, Naoyuki Katayama, Hideto Shimpo, Kazuo Maruyama, Yoshihiro Komada and Masahiro Hirayama in Pulmonary Circulation
Additional file 3 of Overwintering aggregation patterns of European catfish Silurus glanis
Creators: name: Westrelin, Samuel
name: Moreau, Mathieu
name: Fourcassié, Vincent
name: Santoul, Frédéric
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 3 Temperature differences between the main aggregation zone and the deepest point in the lake. Time series are represented over winters 2017 to 2020 (a–d). The solid black line represents the mean daily temperature differences at 0.5 m above the bottom between locations 38 and 42 (see Fig. 1) over the 5-month time series (15 October–15 March). Location 38 is inside the aggregation zone that showed off each winter. Location 42 corresponds to the deepest point in the lake and stands as a reference point. The dates of aggregation given by the breakpoint detection algorithm are represented by vertical blue dotted lines. The period extended to the formation and dislocation of the aggregation is delimited by vertical blue solid lines.
title: Pancreatic Islet Transplantation in the Anterior Chamber of the Eye to Treat Diabetes Mellitus
Creators: name: Ilegems, Erwin
name: Berggren, Per-Olof
Publisher: name: MyCoRe Community
Year: 2024
Subjects: subject: Pancreatic Islet
subject: Transplantation
subject: Diabetes mellitus
subject: 610

description: Today there are more than 400 million people with diabetes worldwide and one of the major problems for the healthcare system is that diabetes is spreading like an epidemic. With regard to treatment of type 2 diabetes and its severe complications the primary focus is to identify novel and more specific drugable targets and then, based on these targets, design new drugs that can be applied for more effective pharmacological regimens of the disease. In type 1 diabetes one major problem is to improve the success rate of islet transplantation. It is clear that the liver is not the optimal site for islet transplantation and there is a need for a local that is more appropriate for pancreatic islet function and survival. Since diabetes is a heterogeneous disease, there is an immediate need for the development of novel more personalized pharmacological treatment strategies. The latter will require the existence of precise in vivo readout systems. Two major challenges in islet cell biology are to understand regulation of islet cell function and survival in the living organism and the extent to which experimental work in rodents reflects the human islet. By using the anterior chamber of the eye as a transplantation site and the cornea as a natural body window we can image islet cell biology in vivo, non-invasively, longitudinally at single cell resolution. I will discuss novel aspects of this in vivo imaging approach involving metabolic islet cell imaging, reporter islet cell imaging, islet cell signaling, islet cell immunology as well clinical islet transplantation. I will also discuss how this approach can be applied to human/non-human primate islets enabling direct comparison with rodent islets in terms of key regulatory steps in islet cell signal-transduction. Finally, I will give some thoughts on future applicability of the living window approach.
description: Transplantation: Ethics, Techniques, Immunology, p. 55
Non-invasive detection of cell-free RNA expression signatures in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is still the leading cause of cancer-related deaths worldwide. While this can be attributed to many factors, a leading reason is that lung cancer is usually diagnosed at late stages when there are limited treatment options. Personalized medicine has revolutionized lung cancer treatment because drugs can now be selected that will specifically kill cancer cells based on their genetic differences. Unfortunately, while these drugs can prolong survival for a time, tumors almost always will become resistant. My lab is interested in developing methods called liquid biopsies that use a simple blood draw to detect when a tumor develops resistance to treatment and to profile the biological mechanisms that are causing resistance. In all individuals, blood is a trash chute for molecules released by the normal death of cells throughout the body, and in cancer patients a small subset of these molecules derive from cancer cells. Here, I propose to develop a liquid biopsy method that characterizes a molecule that has been overlooked in the blood, namely cancer-derived cell-free RNA (cfRNA). I am interested in studying cfRNA because it will likely reveal types of tumor resistance that could not be detected previously. I am also interested in merging expression information from cfRNA with genetic information from cell-free DNA (cfDNA) to improve overall detection of lung cancer. Improved methods for non-invasively detecting and tracking lung cancer could have profound impacts on survival outcomes for patients with this terrible disease.
sj-pdf-2-joh-10.1177_0020731420923532 - Supplemental material for Socioeconomic Inequalities in Small-for-Gestational-Age Births Before and During the Economic Crisis: An Ecologic Study of Trends in 13 Spanish Cities
Creators: name: Domínguez-Berjón, María Felícitas
name: Glòria Pérez
name: Gotsens, Mercè
name: Gènova, Ricard
name: Martín, Unai
name: Ruiz-Ramos, Miguel
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-2-joh-10.1177_0020731420923532 for Socioeconomic Inequalities in Small-for-Gestational-Age Births Before and During the Economic Crisis: An Ecologic Study of Trends in 13 Spanish Cities by María Felícitas Domínguez-Berjón, Glòria Pérez, Mercè Gotsens, Ricard Gènova, Unai Martín, Miguel Ruiz-Ramos and the IMCRISES Project Working Group in International Journal of Health Services
Impact of cigarette smoking on dental pulp mesenchymal stem cells mediated tissue regeneration
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette consumption and exposure is a worldwide issue that has devastating health, social, economic and environmental consequences. Although electronic cigarettes have been advertised as a healthier substitute to tobacco smoking, the aerosol of e-cigarettes still contains a wide range of deleterious products, such as nicotine. In regard to the dental health, cigarette smoking increases risks of orofacial clefts in infants, alveolar bone loss, periodontal disease, oral mucosa cancer and tooth decay. More recently research showed that among more than 1000 people, cigarette smokers were 1.7 times more likely than non-smokers to have root canal treatment (RCT) with 28 years follow up. During RCT, the dental pulp is removed, and the canal is disinfected, filled and sealed. However, there is little report on the biological changes in the dental pulp of the cigarette smokers, which leads to the increased RCT treatment. Dental pulp harbors a mixture of cells including dental pulp mesenchymal stem cells (DPSCs), which are critical in mediating dental pulp regeneration. The easy access and high proliferation rate also make DPSCs a valuable resource of personalized tissue regeneration in the future. Therefore, there is much value in preserving the vital dental pulp during dental treatment. Cigarette smoking has been reported to increase the death of stem cells and suppress the regeneration of the stem cells. In this study, we will investigate whether cigarette smoke extract and one of its major deleterious substances nicotine impair the regenerative capacities of human dental pulp stem cells, and make the dental pulp more susceptible to irreversible inflammation. The ultimate goal is to help dentists make a more accurate prognosis, provide better-personalized treatment plans, and significantly reduce the socio-economic cost of dental treatment for cigarette smoking patients.
title: Sea Level Rise in Europe: Adaptation measures and decision-making principles
Creators: name: Galluccio, Giulia
name: Hinkel, Jochen
name: Fiorini Beckhauser, Elisa
name: Bisaro, Alexander
name: Biancardi Aleu, Rebeca
name: Campostrini, Pierpaolo
name: Casas, Maria Florencia
name: Espin, Océane
name: Vafeidis, Athanasios T.
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: 550 Geowissenschaften

description: ​​​​​​​Sea level rise (SLR) will increasingly impact European countries in the coming decades, posing challenges for coastal decision-making and the design and implementation of adaptation measures to address coastal risks. The impact of SLR extends to its physical damages, encompassing socio-economic and environmental repercussions. European countries are engaged in the development and implementation of adaptation measures to bolster coastal resilience. While significant strides in SLR adaptation have been made in recent years, this paper aims to provide a catalogue of adaptation measures in European basins to guide their design and implementation and to present approaches suitable for supporting coastal adaptation decision-making and addressing uncertainty. The assessment of SLR adaptation measures in Europe is based on the cataloging of 17 measures following International Panel on Climate Change (IPCC) classification of accommodate, protect, advance and retreat responses to SLR, supplemented with sub-key types of measures, including socio-economic, physical and technological as well as nature- and ecosystem-based. Surveying the relevant literature on European sea basins, the paper shows that adaptation strategies on Europe's coasts constitute a mix of hard and soft measures, planning measures, policy developments and stakeholder and community engagements. Across all the basins, a common theme is the shift towards a combination of traditional engineering solutions with soft measures, including nature-based solutions, integrating local communities into decision-making processes and emphasising the importance of continuous monitoring and flexible management strategies. In addition, the context, decisions and experiences with coastal adaptation vary considerably across places and regions in terms of the time horizons considered, the scale of investments involved and the risk acceptance preferences of decision-makers and their constituencies. In this sense, the paper provides an overview of the common features of coastal adaptation decisions and the key aspects that need to be considered in coastal adaptation decision-making, i.e. considering multiple criteria and interests, implementing low-regret and flexible options, keeping future options open and factoring SLR into decisions that need to be made today.
Quantitative and Scalable Tumor Growth Map for Complex Genotypes in Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the deadliest cancer in the world and one of the most devastating consequences of tobacco smoking. Unfortunately, lung cancer is very difficult to treat because it is not just one disease - it is a constellation of many distinct diseases that are caused by an array of genetic changes in the key cellular functioning of the lung cells. It has proven hard to disentangle and understand these changes because the total number of genetic changes and key genes is simply too large for standard approaches. It has also proven very hard to just glean this information from patient data alone - we desperately need scalable and faithful preclinical models. Here we will continue development of very promising mouse models of lung cancer, and specifically those lung cancers that are common among smokers, using the newest technologies such as barcoding and CRISPR that we named Tuba-seq. The key shortcoming of Tuba-seq now is fairly limited ability to generate sufficiently complex genotypes. Here we will use a new modification of the Tuba-seq to allow it to use CRISPR to simultaneously mutate pairs of genes, instead of just one, substantially increasing the scalability of this very promising technology and then carry out a study of how multiple key drivers of cancers interact with one another. We expect that these interactions would be complex and this would have important implications for how cancer genes are studied and how treatments are tailored to particular cancer patients.
sj-pdf-5-joh-10.1177_0020731420923532 - Supplemental material for Socioeconomic Inequalities in Small-for-Gestational-Age Births Before and During the Economic Crisis: An Ecologic Study of Trends in 13 Spanish Cities
Creators: name: Domínguez-Berjón, María Felícitas
name: Glòria Pérez
name: Gotsens, Mercè
name: Gènova, Ricard
name: Martín, Unai
name: Ruiz-Ramos, Miguel
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-5-joh-10.1177_0020731420923532 for Socioeconomic Inequalities in Small-for-Gestational-Age Births Before and During the Economic Crisis: An Ecologic Study of Trends in 13 Spanish Cities by María Felícitas Domínguez-Berjón, Glòria Pérez, Mercè Gotsens, Ricard Gènova, Unai Martín, Miguel Ruiz-Ramos and the IMCRISES Project Working Group in International Journal of Health Services
The Role of p53-Ninj2 loop in Tumor Progression and Metastasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Recent studies indicate that cigarette smoke is considered as an important risk factor for breast cancer development and progression. Cigarette smoke contains 70 carcinogens, most of which are known mutagens and capable of activating oncogenes and inactivating tumor suppressor genes, such as TP53, through genetic mutations. Indeed, TP53 is frequently mutated in breast cancer and the rate of p53 mutation is much higher in smokers that that in non-smokers. Thus, understanding the biology of p53 will help reveal the biological pathway that contributes to the pathology of breast cancer. Nerve injury-induced protein 2 (Ninj2), a cell adhesion molecule, is induced in response to nerve injury. Notably, Ninj2 expression is increased in breast cancer. However, it is not clear whether Ninj2 is involved in breast cancer development. To this end, we performed a pilot study and found that Ninj2 is activated by p53 and in turn represses p53 expression in breast cancer cells. We also found that loss of Ninj2 inhibits the growth of breast cancer cells carrying wild-type p53 but promotes the growth of cancer cells carrying a mutant p53. Thus, we hypothesize that the p53-Ninj2 loop plays a critical role in breast cancer development and progression. To test this, we will determine the mechanism by which p53 and Ninj2 are mutually regulated. We will also determine whether the p53-Ninj2 loop can explored as a therapeutic target for breast cancer carrying wild type p53. Successful completion of this project would further our understanding of the p53 biology and most importantly, lay a foundation for development of new therapeutics for breast cancer patients. Moreover, the research findings from this project will be presented at the First-Year Seminars or Quit Tobacco classes at UC Davis. The P.I. will discuss with the general audience about how smoke causes cancer from a scientific point of view. By these means, we hope that we can develop positive attitude to help smokers quit smoking and assist non-smokers to motivate other people, such as family members or friends, to quit smoking.
Environmental Awareness and Environmental Attitude of In-service Secondary School Teachers (With special Reference of Uttarakhand State)
Creators: name: Chauhan, Ramesh Singh
Publisher: name: figshare
Year: 2022
Subjects: subject: 50203 Environmental Education and Extension
subject: FOS: Earth and related environmental sciences

description: It is well known since the Vedic times that nature and humankind (i.e. Prakriti and Purush) form and inseparable part of the life support system which is made up of five elements i.e. air, water, land; flora and fauna deterioration in anyone inevitably affects the other four elements. The concepts of environment can be best understood as the totally of all components surrounding man. The Environmental pollution panel of United States, Presidents Science Advisory Committee, referred to the environment as “The sum total of social, biological and physical or chemical factors which compose the surrounding of man”. Environment is the common heritage of the people of the world; its protection through prevention for future and restoration of the past damage is needed an enormous task (Khoahoo 1991). To fulfill this task and to save both man and environment on the earth the environmental orientation for mankind is very essential, because man himself has created all environmental problems. The human beings also receive benefits from the natural environment. But most of the times man forgets his sense of responsibility towards maintaining ecological balance due to personal pleasure and gain. The Himalaya is a unique heritage of mankind and it influences our civilization in a variety of ways. This proud full heritage of mankind is in danger due to indiscriminate exploitation and unplanned development. Industrial civilization and unplanned extraction of natural resources which ultimately creates a services which ultimately creates a serious challenge for the environment.
Maternal inhaled nicotine develops a hypertensive phenotype in offspring
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Fetal nicotine exposure, from either maternal smoking or nicotine use during pregnancy, has become a major public concern in modern life. Epidemiological and experimental studies have shown that fetal nicotine exposure is associated with an increased risk of cardiovascular diseases in postnatal life. However, the underlying molecular mechanisms remain unclear. In the vascular wall, an enzyme called endothelial nitric oxide synthase (eNOS) can produce nitric oxide (NO) or superoxide anion (O2•–) depending on the bioavailability of its cofactor tetrahydrobiopterin (BH4). If the vasculature system is undergoing BH4 deficiency, then the eNOS uncouples, and the vasculature produces much more O2•– rather than NO. Endothelial derived NO induces vaso-relaxation while, in contrast, endothelial-derived O2•– promotes vascular constriction. Thus, when eNOS is in the uncoupling stage, it can cause vascular constriction leading to the development of a hypertensive phenotype. In this proposed project, we will employ a pregnant rat model with inhaled nicotine exposure. The offspring will be kept until the adult age of 6 months post prenatal inhaled nicotine (PIN) exposure. Their blood pressures (BP), vascular wall eNOS expressions, and other factors will be determined and compared between the control and PIN exposed groups. We expect that PIN exposure will attenuate the arterial DNA methyltransferase expression level leading to reprogrammed vascular eNOS protein levels, which will result in enhanced eNOS levels in the adult offspring. This progress will lead to eNOS uncoupling that produces less NO and more superoxide anion. Once this phenomenon occurs in their vascular walls, the offspring will develop a hypertensive phenotype in their adult life. Therefore, due to the enzyme eNOS in the vascular wall being epigenetically reprogrammed by nicotine exposure, the proposed study provides novel evidence that children who are prenatally exposed to nicotine have a higher risk of developing a hypertensive phenotype later in life. This project may lead to novel therapeutic approaches to prevent and treat the nicotine-mediated fetal origin of cardiovascular disease.
Atiaia consobrina
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Atiaia
Atiaia consobrina

description: 14. Atiaia consobrina (Gahan, 1892)
 Hammaticherus consobrinus Gahan, 1892: 19.
 Material examinado: Caxias (Reserva Ecológica Inhamum), macho, 09-10.VI.2005, F. Limeira-de-Oliveira col., armadilha luminosa; Mirador (Parque Estadual Mirador, Base da Geraldina), fêmea, 17-21.II.2007, J.C. Silva col.
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 234, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
sj-pdf-1-epb-10.1177_2399808320924437 - Supplemental material for An urban informatics approach to understanding residential mobility in Metro Chicago
Creators: name: Pan, Haozhi
name: Chen, Si
name: Gao, Yizhao
name: Deal, Brian
name: Liu, Jinfang
Publisher: name: SAGE Journals
Year: 2020
Subjects: Geography
Urban and Regional Planning not elsewhere classified

description: Supplemental material, sj-pdf-1-epb-10.1177_2399808320924437 for An urban informatics approach to understanding residential mobility in Metro Chicago by Haozhi Pan, Si Chen, Yizhao Gao, Brian Deal and Jinfang Liu in EPB: Urban Analytics and City Science
Online_Supplementary_Figure_1 – Supplemental material for Effects of Mindfulness-based Interventions on Dementia Patients: A Meta-analysis
Creators: name: Wang, Feng Ling
name: Tang, Qian Yun
name: Zhang, Lu Lu
name: Yang, Jing Jing
name: Li, Yu
name: Peng, Hua
name: Wang, Shu Hong
Publisher: name: SAGE Journals
Year: 2020
Subjects: Nursing not elsewhere classified

description: Supplemental material, Online_Supplementary_Figure_1 for Effects of Mindfulness-based Interventions on Dementia Patients: A Meta-analysis by Feng Ling Wang, Qian Yun Tang, Lu Lu Zhang, Jing Jing Yang, Yu Li, Hua Peng and Shu Hong Wang in Western Journal of Nursing Research
Combined_supplemental_materials-Carvallo_et_al - Ibex-Associated Malignant Catarrhal Fever in Duikers (Cephalophus Spp)
Creators: name: Carvallo, Francisco R.
name: Uzal, Francisco A.
name: Moore, Janet D.
name: Jackson, Kenneth
name: Nyaoke, Akinyi C.
name: Naples, Lisa
name: Davis-Powell, Jordan
name: Stadler, Cynthia K.
name: Boren, Brandon A.
name: Cunha, Cristina
name: Li, Hong
name: Pesavento, Patricia A.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified
Veterinary Medicine

description: Combined_supplemental_materials-Carvallo_et_al for Ibex-Associated Malignant Catarrhal Fever in Duikers (Cephalophus Spp) by Francisco R. Carvallo, Francisco A. Uzal, Janet D. Moore, Kenneth Jackson, Akinyi C. Nyaoke, Lisa Naples, Jordan Davis-Powell, Cynthia K. Stadler, Brandon A. Boren, Cristina Cunha, Hong Li and Patricia A. Pesavento in Veterinary Pathology
sj-pdf-1-std-10.1177_0956462420915395 - Supplemental material for Partner notification and treatment outcomes among South African adolescents and young adults diagnosed with a sexually transmitted infection via laboratory-based screening
Creators: name: Chitneni, Pooja
name: Beksinska, Mags
name: Dietrich, Janan J
name: Jaggernath, Manjeetha
name: Closson, Kalysha
name: Smith, Patricia
name: Lewis, David A
name: Matthews, Lynn T
name: Smit, Jenni
name: Ndung’u, Thumbi
name: Brockman, Mark
name: Gray, Glenda
name: Kaida, Angela
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-std-10.1177_0956462420915395 for Partner notification and treatment outcomes among South African adolescents and young adults diagnosed with a sexually transmitted infection via laboratory-based screening by Pooja Chitneni, Mags Beksinska, Janan J Dietrich, Manjeetha Jaggernath, Kalysha Closson, Patricia Smith, David A Lewis, Lynn T Matthews, Jenni Smit, Thumbi Ndung’u, Mark Brockman, Glenda Gray, Angela Kaida and on behalf of the AYAZAZI Research Team in International Journal of STD & AIDS
JRS918236 Supplemental Material - Supplemental material for Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework
Creators: name: Hodgson, Sam
name: Watts, Isabella
name: Fraser, Simon
name: Roderick, Paul
name: Hajira Dambha-Miller
Publisher: name: SAGE Journals
Year: 2020
Subjects: Medicine

description: Supplemental material, JRS918236 Supplemental Material for Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework by Sam Hodgson, Isabella Watts, Simon Fraser, Paul Roderick and Hajira Dambha-Miller in Journal of the Royal Society of Medicine
Multilayer investigation of resistance mechanisms to WEE1 inhibition in Small Cell Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Mammalian cells have adapted precise mechanisms that minimize possibilities for error during cell division. The disruption of these mechanisms is often associated with the development of human diseases such as cancer. My proposal focuses on the concept that while DNA mutations can promote cancer, the accumulation of too many mutations in a cancer cell can be exploited to kill this cell. SCLC is an aggressive lung cancer, mainly caused by heavy smoking, and is driven by inactivating mutations in two key cell cycle genes, RB and p53. These mutations mostly affect the early steps of the cell cycle but are not readily ‘druggable’. Interestingly, however, drugs targeting late stages of the cell cycle progression have been recently developed. It has been proposed that disrupting these late cell cycle steps in cancer cells in which the early steps are already disrupted, may lead to catastrophic cell division and cell death. The cancer genome accumulates many mutations and if the cancer cell is unable to repair them before dividing, this may lead to cell death. Indeed, these drugs, including inhibitors of the WEE1 protein, involved in a late stage of cell division (mitosis), have shown promising results in SCLC patients; however, evidence of resistance to treatment has also already emerged from these studies. My project aims to elucidate the mechanisms that control how cells respond to WEE1 inhibition, why they sometimes become resistant to this inhibition, and how to resensitize them with combinational treatments. In brief, I have performed unbiased genome-wide screens in SCLC cells to identify genes whose loss of function may regulate how SCLC cells respond to WEE1 inhibition. From these screens, I have already uncovered candidate genes important for WEE1 inhibition resistance and sensitivity. I will use unique tools developed in the Sage lab, including mouse models, to identify additional candidates and validate top candidate genes involved in WEE1 resistance. I will also examine the role of these candidates at the single cell level, which allows to determine how key signaling pathways respond to specific genetic mutations in single cells within heterogeneous populations. I hope that these experiments will identify novel therapeutic strategies in SCLC and other cancer types.
Modelos Viscoelásticos Fracionários Aplicados Em Reologia De Polimeros Fundidos
Creators: name: Ribeiro Alves, Bruno Manuel
Publisher: name: Zenodo
Year: 2015
Subjects: Fractional Viscoelastic Models

description: Os materiais poliméricos possuem uma estrutura complexa, que frequentemente origina comportamentos difíceis de antecipar, por vezes contra-intutitivos, como são os casos: da diferença de tensões normais não nulas, do efeito de Weissenberg, do inchamento e da retração elástica.

Ao longo do tempoforam propostos diversos modelos para o comportamento destes materiais, que têm por objetivopermitir prever o seu comportamento e assim facilitar a conceção de sistemas que os incorporem. Os modelos reológicos clássicos apresentam diversas limitações, quer por não serem capazes de prever todos os aspetos relevantes ou por serem válidos para gamas estreitas das condições de fluxo.

Recentemente, surgiu um novo tipo de abordagem, baseada em derivadas e integrais de ordem não inteira. Este tipo de derivadas, deu origem a equações fracionárias que evoluíram da matemática pura e aplicada, para a aplicação a diversos ramos da engenharia. A utilização dos

modelos fracionários em equações constitutivas, iniciou-se em 1921, sendo  estes modelos baseados num elemento “springpot”, que permite interpolar o comportamento dos elementos tradicionais mola e amortecedor, através da ordem considerada para a derivada.

Na maioria dos casos, o modelo fracionário surge apenas como um modelo generalizado, que, embora se consiga perceber a influência dos novos parâmetros, não existe ainda uma derivação completa, baseada nas leis da física fundamental. O facto de esta ser uma teoria recente, faz com que ainda não esteja estabilizada e fundamentada, surgindo então a necessidade de aferir a adequação destes novos modelos viscoelásticos fraccionários, para a modelação de fluidos complexos.

O principal objectivo deste trabalho é avaliar a capacidade de modelação destes novos modelos fracionários do comportamento de polímeros fundidos. Para tal, serão caracterizados experimentalmente diferentes tipos de polímeros, e, os diferentes modelos viscoelásticos propostos serão estudados, ajustados e comparados.
RAQAMLI TEXNOLOGIYALAR YORDAMIDA O'QUVCHILARNING ILMIY TADQIQOT KO'NIKMALARINI SHAKLLANTIRISH: PEDAGOGIK VOSITALAR VA USULLAR
Creators: name: Risqulova, Ziyoda
name: Ravshanov, Umidjon
Publisher: name: Zenodo
Year: 2025

description: Tadqiqotda raqamli vositalarning ilmiy tadqiqotlar jarayonida qanday ahamiyatga ega ekanligi, ularning o‘quvchilarga ma'lumotlar to‘plash, tahlil qilish va natijalarini taqdim etish imkoniyatini yaratishi ta'kidlanadi. Shuningdek, maqolada pedagogik vositalar, metodlar va raqamli texnologiyalarni o‘quv jarayoniga qanday integratsiya qilish, ilmiy ishlar uchun zarur bo‘lgan analitik va kommunikativ ko‘nikmalarni rivojlantirishga qaratilgan yondashuvlar muhokama qilinadi.
Quality Management in Higher Education: The Role of IQAC in Academic Audit
Creators: name: Chauhan, Ramesh Singh
Publisher: name: figshare
Year: 2022
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences

description: Academic Audit is an important tool to control and maintain standards in academic sector. It has been found highly relevant by the experts across the world. It is an integral part of the dynamics of higher education and its regulation in many countries that aspire to achieve excellence and international standing. Academic audit helps institutions to introspect and improve their quality. The fundamental purpose of quality assurance process is to provide the stakeholders with information about the research and education. The present paper intends to probe into the possible role of Internal Quality Assurance Cell (IQAC) in Academic Audit as a measure to expedite its quest for quality
Cancer cells alter protein synthesis rates to drive tumorigenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cancers caused by smoking, like all cancers, arise when cells in the body stop abiding the normal rules of proliferation and start dividing uncontrollably, hurting the rest of the body in the process. In order to achieve such growth, cancer cells need a higher than usual amount of proteins, the building blocks of all cells and life. Normally, protein production starts with the DNA, which contains the sequences of all proteins, which is copied into mRNA which is then translated into proteins by specialized structures called ribosomes. Because this process of translation is key in producing proteins, cancer cells try to hijack the ribosome and the rest of the translational machinery in order to alter which and how much proteins are produced. One component that is hijacked by cancer is a protein called DDX3, which in its normal function untangles mRNA to allow it to be translated. Because DDX3 only untangles specific mRNA structures, it affects only a specific subset of mRNAs and hence it can promote the production of only a subset of proteins. Different cancers, including cancers related to tobacco, take advantage of DDX3 in different ways to promote the production of different proteins, based on what is more useful to each cancer type. In order to be able to treat these tumors, we need a better understanding of DDX3 and what it does in order to counteract its activity. The research outlined in this proposal will investigate what makes up this subset of mRNAs and proteins and how increasing their production contributes to the spread of cancer. First, I will make different mRNA sequences and structures to determine which ones are being untangled by DDX3. Secondly, I will use a technique called ribosome profiling to determine which proteins are produced when DDX3 increases in cells exposed to tobacco. Finally, I will grow different cancer cells in the lab that have different amounts of DDX3 in order to investigate which cancers take advantage of DDX3. We will determine if they used the proteins that are produced thanks to DDX3 to move, grow, metastasize, and/or replicate. In conclusion, once this study will be over, we will know more about one mechanism that cancer uses to grow and spread, and we will be able to develop new drugs to stop cancer from employing DDX3 in such a way.
Characterization of Smoking-Associated Circulating Tumor DNA (ctDNA) for Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is a smoking-related disease and is the number one cause of mortality amongst all cancers. By the time lung cancer is usually detected, the patient presents with a late-stage diagnosis. Thus, screening in high-risk patients (such as smokers) to detect early stage lung cancer is sorely needed. Radiographic imaging can be used for screening, but they lack the ability to catch tumors early and do not provide any genetic information. Liquid biopsy, an emerging clinical approach, can solve this problem by non-invasively detecting lung cancer in bodily fluids by measuring circulating tumor DNA (ctDNA) fragments shed by tumor cells. We have developed a technology, electric field-induced release and measurement (EFIRM) liquid biopsy (eLB) which can reliably assess ctDNA of two major subtypes of lung cancer mutations using a small volume of blood. These two major subtypes, however, only provide coverage for 15% of lung cancer subtypes. Therefore, effort must be made to expand the number of detectable mutations and in particular, those associated with smoking such as mutations in a gene called KRAS. The difficulty with expanding targets detectable by eLB is that it requires true clinical samples containing ctDNA from cancer patients. Attempts to fabricate artificial ctDNA is a challenge. A major reason is because there is limited understanding of ctDNA biology in terms of its various traits. In this proposal we wish to achieve four objectives. Firstly, we wish to complete development of an eLB assay for smoking-associated KRAS mutations in ctDNA and test its efficacy on clinical samples. Secondly, we wish to describe the biological characteristics of the smoking-associated KRAS ctDNA targets that are detected by eLB in patient plasma samples. Thirdly, we wish to observe the similarity between the biology in ctDNA from clinical samples and cultured cells harboring the same smoking-associated KRAS mutations. Finally, we wish to attempt to use this cell culture to create a surrogate KRAS ctDNA model that can be used as standardized material for ctDNA detection development. The findings from this project will be essential for learning more about ctDNA and cancer biology and will aid in expanding EFIRM’s panel of ctDNA targets. This will help advance a clinical liquid biopsy approach for early detection for smoking-associated lung cancer.
TREATMENT OF HIGH BLOOD PRESSURE IN ELDERLY PATIENTS WITH CHRONIC KIDNEY DISEASE
Creators: name: Mirzaeva, Gulchexra
name: Nazarova, Nigina
name: Rakhimova, Gulsum
name: Xasanova, Malika
Publisher: name: Zenodo
Year: 2024

description: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), which have nephroprotective effects, are first-line drugs (FL) for treatment of arterial hypertension (AH) in patients with chronic kidney disease (CKD). However, these groups of drugs have a number of contraindications, certain adverse drug reactions, unwanted drug interactions and therefore cannot be prescribed in all AH patients with CKD. Therefore, real clinical practice studies are needed to assess the real frequency of nephroprotective drugs prescription, especially in the elderly.
Additional file 2 of Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock
Creators: name: Pode-Shakked, Naomi
name: Ceschia, Giovanni
name: Rose, James E.
name: Goldstein, Stuart L.
name: Stanski, Natalja L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 2: Methods.
Inhibiting a DNA damage control mechanism as a strategy to selectively kill lung cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Modern sequencing technology has revolutionized cancer drug development through enabling researchers to pinpoint the exact genes, or ‘drivers’, that enable different kinds of tumors to grow. This technology has drastically increased the survival rates for cervical, breast, and testicular cancer patients among others. Despite these advancements, progress in our ability to treat lung cancer has remained stagnant, evidenced by a still dismal survival rate. Lung cancer is physiologically unique in that its genome is highly unstable, or in other words, it mutates its genes very quickly. Thus, it is difficult to leverage sequencing technology to pinpoint genes to therapeutically target, as mutated genes are rarely the same between patients. Moreover, while some mutated genes have been identified as recurring in small patient populations and have available therapies, patients often relapse after an initial period of remission. This is likely due to the ability of lung cancer to mutate rapidly and thus develop secondary growth and survival pathways. Therefore, it would be prudent to develop alternate strategies to target lung cancer outside of driver mutation-based therapies. Paradoxically, the rapid mutation rate that makes lung cancer hard to treat with modern drug development strategies makes it vulnerable to ‘old school’ drugs. For example, chemotherapeutic agents such as cisplatin have been the front-line therapy for the last 30 years. Cisplatin is genotoxic; it damages DNA in cells, and thereby kills them. Because the genome in lung cancer is unstable and thus has high levels of DNA-damage to begin with, its ability to buffer additional damage from cisplatin is impaired relative to healthy cells. However, cisplatin at therapeutic dosages still generates damage in healthy tissue, inducing side-effects such as toxicity in the kidneys. Selectively inducing DNA-damage in tumor cells by inhibiting cancer genes that prevent damage accumulation is an intriguing alternate strategy for treatment. Interestingly, a protein complex named INO80C is over-active in lung cancer, and acts to prevent DNA damage only in cancer-like conditions. We propose that inhibition of INO80C activity will selectively amplify cisplatin’s toxicity in lung cancer cells, enabling lower dosages that promote increased efficacy in killing cancer cells and decreased off-target toxicity in patients.