title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð³Ð¾ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ð° Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Studying the molecular mechanism of silver nano-particles antiviral effect
Creators: name: ÐÐ»Ñ ÐÑÐ¼Ð°Ð½, ÐÐ°Ð»Ð¸Ð´
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
ÐÐ¸ÑÑÑÐ¾Ð»Ð¾Ð³Ð¸Ñ
Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ ÑÐµÑÐµÐ±ÑÐ°
Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ Ð¼ÐµÐ´Ð¸
Ð³ÑÐ¸Ð¿Ð¿ ÑÐ¸Ð¿Ð° Ð
ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð¼ÐµÐ´Ð¸
ÑÐµÑÑÐ»Ð¾Ð¿Ð»Ð°Ð·Ð¼Ð¸Ð½
Ð¼ÐµÑÐ°Ð»Ð»Ð¾ÑÐ¸Ð¾Ð½ÐµÐ¸Ð½
silver nano particles
copper metabolism
influenzas A
copper machinery
ceruloplasmin
metallothionein

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description: Influenza is transmittable viral disease that cause acute respiratory infection, still till now influenza virus threat the global health with every year approximately 10% death rate which may increase because of unpredictable pandemic, influenza virusÂ  antigenic mutation decrease the efficiencyÂ  of influenza vaccines which also has gain ability to resist anti influenza chemo therapy drugs, the finding of new influenza drug is essential for global health, silver nano particles is one of the most studied nanoparticles know a days because of it is anti-bacterial anti-microbial effects, in the case of influenza it is not well studied field but it has capability to replace the copper ion without threatening human health, copper in it is turn is one of the essential micro nutrients to human with uncounted uses and it is also crucial to influenza virus replication, the purpose of the study is to investigateÂ  the mechanism The aim of the study to evaluate the molecular mechanism of silver nano-particles antiviral effect, dose-dependent analyses were performed on CBA mice, the effect of AgNPs on gene expression of copper machinery and viral genome using rt-qPCR, western blot and oxidase activity were also performd in samples infected with influenza virus and treated with silver nano particles. The results of this study show a dose-dependent decrease in lethality of the virus with modulating effect on copper machinery and great impact on Metallothioneins, Ceruloplasmin, CTR1 this study suggests thatÂ  AgNPs alter the gene expression in a way that counter the viral infection effect on the copper metabolism-related genes and proteins.