cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An expansion for Neutrino Phenomenology
Creators: name: Grinstein, Benjamin
name: Trott, Michael
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We develop a formalism for constructing the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) matrix and neutrino masses using an expansion that originates when a sequence of heavy right handed neutrinos are integrated out, assuming a seesaw mechanism for the origin of neutrino masses. The expansion establishes relationships between the structure of the PMNS matrix and the mass differences of neutrinos, and allows symmetry implications for measured deviations from tri-bimaximal form to be studied systematically. Our approach does not depend on choosing the rotation between the weak and mass eigenstates of the charged lepton fields to be diagonal. We comment on using this expansion to examine the symmetry implications of the recent results from the Daya-Bay collaboration reporting the discovery of a non zero value for theta_{13}, indicating a deviation from tri-bimaximal form, with a significance of 5.2 sigma.
description: 16 pp, 1 figure v2: Jhep version, more exposition/description,results unchanged
Laparoscopic Transgastric Cystogastrostomy for Debridement and Drainage of “Walled-Off Pancreatic Necrosis”
Creators: name: D’Ambra, Marielda
name: Alsaati, Hani
name: Abu Hilal, Mohammad
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Walled-off pancreatic necrosis (WOPN) is a known complication of acute and chronic pancreatitis. Indications for treatment of WOPN are infection, a rapid increase in size, pain, or biliary or duodenal obstruction. Endoscopic transgastric treatment of pseudocysts with liquid content is successful in approximately 90% of patients. However, the treatment of WOPN is less satisfactory. Objective To evaluate the clinical results of laparoscopic transgastric cystogastro­stomy and to determine the potential advantages of this new therapeutic option to treat WOPN. Methods We considered patients with WOPN treated by laparoscopic transgastric cystogastro­stomy. This procedure was performed by ultrasonographically localizing the WOPN and opening the anterior stomach wall to expose the posterior gastric wall in close contact with the necrotic cavity. After creating a sufficient drainage orifice using diathermy a longer anastomosis was performed using an endoscopic stapler (Echelon 60). The cavity is then debrided using soft graspers and suction to remove as much as possible the necrotic tissue. Results From September 2012 five patients underwent laparoscopic cystogastrostomy: 2 males and 3 females with a median age of 51 years (range: 47-56 years). In all patients the WOPN developed after acute pancreatitis and the median delay between the acute onset and surgery was 3 months (range: 1-20 months). The median WOPN diameter was 13 cm (range: 9-23 cm). The procedure was performed with 4 trocars in 4 patients and 5 trocars in one. Mean operative time was 170 minutes (range 160-180 min). No mortality and postoperative morbidity were recorded. Median postoperative stay was 9 days (range 5-23 days). One patient was readmitted for further open necrosectomy of another cavity. With a median clinical and radiological follow-up of 6 months (range: 1-8 months), no recurrence of WOPN was observed. Conclusion Although small number of patients, laparoscopic transgastric cystogastro­stomy is a safe and effective procedure for the debridement and drainage of WOPN in contact with the posterior wall of the stomach.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
Cyrtocamenta Brenske 1897
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Cyrtocamenta

description: Cyrtocamenta Brenske, 1897
[15 species].
Type species Cyrtocamenta pygamea Brenske, 1897, by subsequent designation of Ahrens (2000).
Microcamenta Brenske, 1898b.
Type species Microcamenta transvaalensis Brenske, 1898, by monotypy. Synonymy by Ahrens (2000).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 140, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Laparoscopic Left Pancreatectomy for Primary Pancreatic Adenocarcinoma
Creators: name: Casadei, Riccardo
name: D'Ambra, Marielda
name: Richardson, John
name: Ricci, Claudio
name: Minni, Francesco
name: Abu Hilal, Mohammad
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Laparoscopic left pancreatectomy has been shown to be feasible, safe and efficient technique for the treatment of benign and pre-malignant lesions of the left half side of the pancreas, but there is still controversy when it comes to the management of the malignant lesion of the pancreas. Objective To evaluate the feasibility, outcomes and oncological efficiency of the laparoscopic approach of primary pancreatic adenocarcinoma in two major tertiary centers. Methods Data from a prospectively updated databases of 105 patients operated between 2005 and 2013 was analyzed. Data included demographics, conversion rate, operative time, blood loss, length of hospital stay, postoperative complications according to Clavien-Dindo classification (score ≥3), mortality, lymph node retrieval and margin status. Results Fifteen patients (14.3%) underwent laparoscopic left pancreatectomy (LLP) for ductal adenocarcinoma; 7 patients were (46.7%) females and 8 (53.3%) males. The mean age of the patients was 62 years (range: 40-74 years). In three patients a multivisceral en bloc resection was accomplished (adrenalectomy: 2; mesocolonic resection: 3; and duodenojejunal flexure: 2). One patient was converted (6.6%). Mean operative time was 230 min, (range: 120-370 min). Mean blood loss was 228 mL (range: 50-900 mL). Average post-operative stay was 6 days (range: 2-17 days). Complication rate according to the classification of Clavien-Dindo (score ≥3) was 13.3% (2/15) and grade B/C postoperative pancreatic fistula rate was 20% (3/15). Average nodal rate was 14 (range: 3-41). R0 resection was achieved in 85.7% (12/14; in one patient R status is not yet available). Conclusion In expert centers, laparoscopic left pancreatectomy for primary pancreatic malignancy is feasible with excellent short term clinical and oncological results. However randomized studies are not yet available and are now seriously needed to shed light on future direction.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
Phase transition in the Jarzynski estimator of free energy differences
Creators: name: Suárez, Alberto
name: Silbey, Robert
name: Oppenheim, Irwin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The transition between a regime in which thermodynamic relations apply only to ensembles of small systems coupled to a large environment and a regime in which they can be used to characterize individual macroscopic systems is analyzed in terms of the change in behavior of the Jarzynski estimator of equilibrium free energy differences from nonequilibrium work measurements. Given a fixed number of measurements, the Jarzynski estimator is unbiased for sufficiently small systems. In these systems, the directionality of time is poorly defined and configurations that dominate the empirical average, but which are in fact typical of the reverse process, are sufficiently well sampled. As the system size increases the arrow of time becomes better defined. The dominant atypical fluctuations become rare and eventually cannot be sampled with the limited resources that are available. Asymptotically, only typical work values are measured. The Jarzynski estimator becomes maximally biased and approaches the exponential of minus the average work, which is the result that is expected from standard macroscopic thermodynamics. In the proper scaling limit, this regime change can be described in terms of a phase transition in variants of the random energy model (REM). This correspondence is explicitly demonstrated in several examples of physical interest: near-equilibrium processes in which the work distribution is Gaussian, the sudden compression of an ideal gas and adiabatic quasi-static volume changes in a dilute real gas.
description: 29 pages, 5 figures, accepted for publication in Physical Review E (2012)
Effect of Hyperbaric Oxygen Treatment and Gemcitabine on Apoptosis in Pancreatic Ductal Adenocarcinoma Cells
Creators: name: Casarotto, Andrea
name: Bosio, Claudio
name: Bosco, Gerardo
name: Guizzon, Luca
name: Yang, Zhongjin
name: Megighian, Aram
name: Cannato, Marta
name: Toniolo, Luana
name: Nasole, Emanuele
name: Camporesi, Enrico
name: Reggiani, Carlo
name: Garetto, Giacomo
name: Bassi, Claudio
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies with dismal prognosis. Gemcitabine is one of first-line therapies for locally advanced PDAC; however, severe resistance is responsible for poor survival and response rate. There is evidence that administration of HBOT can enhance the delivery of oxygen to hypoxic tumor cells and increase their susceptibility to the cytotoxic effects of chemotherapy. We hypothesized that the anticancer activity of gemcitabine may be enhanced if tumor cells were placed in oxygen rich environment. Objective This study was designed to evaluate the effects of gemcitabine, hyperbaric oxygen treatment (HBOT) and their combination on apoptosis of tumor cells. Materials and methods PANC-1 and AsPc-1 tumor cell lines were used because they are sensitive to gemcitabine. Cultured tumor cells were treated with gemcitabine at its growth-inhibitory concentration (IC50)value for the cell line PANC-1: 3.25x10-8 M and AsPc-1: 1.27x10-7 M, and HBOT at 2.5 ATAfor 90 minutes or combination of both. Twenty-four hours after treatment, the apoptotic cells in each group were analyzed and apoptotic index (AI) was calculated. Results PANC-1 cell line: HBOT alone had no effect on AI: 6.5±0.03 vs. 5.9±0.01. HBOT before and after gemcitabine did not increase AI in comparison to gemcitabine alone: AI: 8.2±0.02, 8.5±0.02 vs. 8.1±0.02. Combination of HBOT and gemcitabine significantly increased AI 10.7±0.02 (P<0.001 vs. all groups). AsPc-1 cell line: HBOT alone had no effect on AI: 5.9±0.03 vs. 5.9±0.01. HBOT before and after gemcitabine did not increase AI in comparison to gemcitabine alone: 8.2±0.02, 8.4±0.02 vs. 8.0±0.01. Combination of HBOT and gemcitabine significantly increased AI 9.7±0.02 (P<0.001 vs. all groups). Conclusion Our data show that HBOT alone, or administered before and after gemcitabine has no effect on apoptosis in PDAC cells in vitro. HBOT significantly increased apoptosis when administered with gemcitabine.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
Diplotropis Boheman 1857
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Diplotropis

description: Diplotropis Boheman, 1857 (not Diplotropis Günther, 1872)
[3 species].
Type species Diplotropis nigrina Fåhraeus, 1857, by subsequent designation of Lucas (1920).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 140, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Pancreatic Surgery in Patients with Concomitant Liver Cirrhosis: A Single Centre Experience
Creators: name: Maggino, Laura
name: Landoni, Luca
name: Malleo, Giuseppe
name: Marchese, Tiziana
name: Mascetta, Giuseppe
name: Butturini, Giovanni
name: Salvia, Roberto
name: Bassi, Claudio
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Liver cirrhosis is known to negatively affect the outcome of various types of surgery, but very poor data on the safety of pancreatic surgery in cirrhotic patients are available. As a consequence, a consensus on the operability of this subgroup of patients do not exist, and the fear of complications often results in the decision to avoid surgery. However, pancreatic surgery is presently the only curative option for malignant disease, and an aggressive tumor resection is therefore mandatory whenever possible. Only one published study has investigated the risk of pancreatic surgery in cirrhotic patients, concluding that whereas Child A patients display increased complications but a relatively low mortality, surgery in Child B patients should be avoided. Objective To investigate the outcome of cirrhotic patients who underwent surgery for a pancreatic disease at our institution. Methods Between 2003 and 2010, 53 patient with pancreatic pathology and concomitant liver cirrhosis came to our observation. Among these 17 were addressed to surgery. We retrospectively analyzed data about the clinical-pathological features of these patients, classified them on the basis of the Child score and evaluated the post-operative outcome. Fourteen patients were Child A, 3 Child B; 9 underwent a radical pancreatic resection, 6 a palliative procedure, 2 a laparoscopic abdominal exploration. The main indication for surgery was pancreatic adenocarcinoma (n=11). Results Among the 17 operated patients, 13 had a regular post-operative course (76%), 4 experienced a complication (24%). Only 1 patient (6%) died due to surgery-related complications. The mean post-operative hospital stay was 9.2 days. Significantly, all the Child B patients had a regular post-operative course. Conclusions In our experience, the presence of liver cirrhosis, even Child B cirrhosis, is not an absolute contraindication for pancreatic surgery. A careful preoperative selection and an adequate post-operative care can offer an acceptable clinical outcome even in those patients usually considered not eligible for surgery.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
Scaptomyza (Scaptomyza) flava
Creators: name: Ivannikov, A. V.
name: Katokhin, A. V.
name: Sidorenko, V. S.
Publisher: name: Zenodo
Year: 1998
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza flava

description: Scaptomyza (Scaptomyza) flava (Fallén, 1823)
DISTRIBUTION. Russia: West Siberia [4], European part, East Siberia, Far East. Azores, Madeira, Canary Is., Europe, Afghanistan, Uzbekistan, North-East China, Mongolia, Japan.
description: Published as part of Ivannikov, A. V., Katokhin, A. V. & Sidorenko, V. S., 1998, List Of Droso- Philidae (Diptera) Of West Siberia, pp. 12-16 in Far Eastern Entomologist 57 on page 16, DOI: 10.5281/zenodo.10085027
ADM-like Hamiltonian formulation of gravity in the teleparallel geometry
Creators: name: Okolow, Andrzej
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present a new Hamiltonian formulation of the Teleparallel Equivalent of General Relativity (TEGR) meant to serve as the departure point for canonical quantization of the theory. TEGR is considered here as a theory of a cotetrad field on a spacetime. The Hamiltonian formulation is derived by means of an ADM-like 3+1 decomposition of the field and without any gauge fixing. A complete set of constraints on the phase space and their algebra are presented. The formulation is described in terms of differential forms.
description: 43 pages, LaTeX2e; the original 73 page paper arXiv:1111.5498v1 was revised and divided into two parts. The present paper is the first part of the original one (the second part is available as arXiv:1309.4685)
Empecamenta Brenske 1895
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Empecamenta

description: Empecamenta Brenske, 1895
[53 species].
Type species Empecamenta pilifera Brenske, 1895, by monotypy.
Isocamenta Kolbe, 1910.
Type species Isocamenta montana Kolbe, 1910, by subsequent designation of Ahrens (2000).
Synonymy by Moser (1916a).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 140, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
title: Can't Share? Won't Share?
title: Examining work-family decision making processes at the transition to parenthood
titleType: Subtitle
Creators: name: Stovell, Clare
Publisher: name: Lancaster University
Year: 2021
Subjects: work and family
Division of labor
Childcare
gender
parenting
motherhood
fatherhood
work and family interface
Decision making

description: Since the advent of parenthood is a catalyst for increasing and long-lasting gender inequalities, this thesis investigates why heterosexual couples adopt traditional, gendered divisions of household labour (or otherwise) at this time. Explanations offered by the work-family literatures raise questions regarding how far couples ‘can’t’ or ‘won’t’ share and much research has explored the drivers of work-family divisions. However, few studies have looked in-depth at how these important decisions are made in practice. Using a quantitative recruitment survey and qualitative interviews with 25 heterosexual couples across the transition to parenthood, this thesis explores how first-time parents in the UK negotiate the division of parental leave, paid work and childcare. In particular, it asks how constraints and ‘preferences’ interact in this process. The thesis makes a key theoretical contribution to explanations for gendered household divisions of paid and unpaid work by demonstrating a reciprocal relationship between work-family preferences and constraints. In keeping with the findings of existing studies, constraints shaped desires - what has been referred to as ‘adaptive preferences’ - but at the same time individuals’ perceptions of and responses to constraint were varied and shaped by their ideals and priorities – something that has so far received less attention in the literature. In light of these findings, the thesis uses a framework of ‘motivation’ and the duality of structure and agency to understand decision making. Underpinning these findings are further contributions to: 1) explanations for lack of active negotiation and discussion among couples; 2) understandings of work-family preferences; and 3) interpretations of survey measures. These findings suggest avenues for improving gender equality at the transition to parenthood and have important implications for policy on parental leave and flexible working.
Pancreatic Frozen Section in Distal Pancreatectomy: Verona Experience with Harmonic Focus®
Creators: name: De Pastena, Matteo
name: Landoni, Luca
name: Mascetta, Giuseppe
name: Capelli, Paola
name: Malleo, Giuseppe
name: Butturini, Giovanni
name: Salvia, Roberto
name: Bassi, Claudio
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Pancreatic head resection is performed with low mortality, but morbidity remains high. Extensive preparation, long operating times, intraoperative blood loss and the need for blood transfusions are risk factors for post-operative morbidity. Many authors demonstrated that the use of an ultrasonic dissection device in distal pancreatectomy might significantly reduce operating time, intraoperative blood loss and the need for blood transfusions. Intraoperative frozen section analysis has traditionally played an important role in the surgical management of pancreatic lesions. Currently limited data exist in the surgical literature regarding the accuracy of frozen section analysis for the purpose of determining resectability and assessing final margin status. No data are available about the feasibility of the frozen section performed with the harmonic scalp. Methods A retrospective review was performed for all patients who underwent open, laparoscopic or robotic distal pancreatic resection for cancer (adenocarcinoma or IPMN, or NET) at our institution from 2010 to 2012. The pancreatic transection was effectuated by scalpel or by harmonic scalpel (Harmonic Focus®). Frozen section was performed routinely. Results One-hundred and two distal pancreatic resections were performed in our Institution. In 79 patients the pancreatic transection was effectuated by scalpel and in all cases the final pathological diagnosis coincided with the frozen section. In 22 patients, the pancreatic section was performed using the Harmonic Focus®. Two frozen sections resulted negative for neoplastic cell research but were positive at definitive examination. Conclusion Use of an ultrasonic dissection device (Harmonic Focus®) in distal pancreatectomy is safe and feasible. The electrocution of the harmonic scalp could distort the frozen section examination so, where possible, we suggest performing the frozen section with the scalpel.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
Laparoscopic and Robot-Assisted Surgery for Pancreatic Neuroendocrine Tumors: Single-Center Experience
Creators: name: Malpaga, Anna
name: Butturini, Giovanni
name: Malleo, Giuseppe
name: Marchese, Tiziana
name: Damoli, Isacco
name: Esposito, Alessandro
name: Mascetta, Giuseppe
name: Landoni, Luca
name: Casetti, Luca
name: Salvia, Roberto
name: Bassi, Claudio
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Pancreatic neuroendocrine tumors (pNET) in many cases are small and could be considered well suited for removal by minimally invasive approach. There are few large series that describe the technical feasibility, outcome and histo­pathology associated with laparoscopic (LS) and robot-assisted (RA) pancreatic surgery. Objective To evaluate the efficiency of minimally invasive surgery for pNET, considering the revolutionary field of RA pancreatic surgery. Methods We performed a retrospective analysis of all minimally invasive pancreatic resections (LS and RA) at Pancreas Institute of Verona between January 2002 and May 2013. We reviewed operative management information and compared clinical and histological data with short- and long-term outcomes. Standard statistical methods were used. Results Fifty consecutive patients were selected (26 females, 24 males), with a median age of 55 years (IQR: 24-81 years). Forty-three LS procedures were performed: 17 distal pancreatectomies with splenectomy (DPS), 12 spleen-preserving distal pancreatectomies (DS), 12 enucleations (En), and 2 middle pancreatectomies (MP). Seven procedures were performed robotically: 3 DS, 3 DPS, 1 En. Five patients (10%) required conversion to open surgery. The median operative time of En was 125 min (IQR: 100-166 min), of DPS, DS and MP was 210 min (IQR: 150-240 min). Pancreatic fistula rate was 32% (6 cases classified by ISGPF as grade A, 8 grade B, and 2 grade C). The median hospital stay was 7 days (IQR: 6-10 days). All but one resections were R0. On histological examination, median size of pNET was 17.5 mm (IQR: 12.2-29.2 mm); 10 were functioning pNET (9 insulinomas, 1 ACTH); 37 were G1 pNET, 12 G2 and 1 G3; regional lymph­adenectomy was performed in 20 DPS, with a median of 13 lymphnodes removed and a Ln Ratio of 0.05. No patient developed recurrences or metastases. Conclusion The present study confirms that LS and RA pancreatic resections for pNET are feasible, with comparable morbidity, fistula formation and oncological results to that observed after open surgery, but with all known advantages of minimally invasive techniques. The crucial point is the right pre-operative evaluation and selection of each patient.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
A Single Centre Experience in Minimally Invasive Surgery for Pancreatic Cystic Lesions
Creators: name: Marchese, Tiziana
name: Butturini, Giovanni
name: Malleo, Giuseppe
name: Malpaga, Anna
name: Damoli, Isacco
name: Salvia, Roberto
name: Bassi, Claudio
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context Minimally invasive surgery is considered a safe and feasible procedure in selected patients with pancreatic tumors. Objective To present our short-term outcomes of laparoscopic and robotic surgery on pancreatic cystic lesions. Methods A retrospective analysis of hospital records was performed for patients who underwent minimally invasive surgery for suspected pancreatic cystic lesions from May 1999 to May 2013. We analyzed demographics, intraoperative and postoperative course, and pathological details. Results A total of 90 consecutive patients (mean age 42 years) was selected. Eighty-two patients (6 men) underwent laparoscopic distal pancreatectomy (DP) either spleen-preserving (SPDP) or not. Preservation of the spleen was successful in 26 patients over 29. Five women underwent robotic distal pancreatec­tomy (RDP), and in 3 an enucleation was performed. The median operative time was 140 minutes (range: 90-320 minutes) for DP, 240 minutes (range: 210-320 minutes) for RDP, and 85 minutes (range: 75-90 minutes) for enucleation. There was no conversion to open surgery. Two patients required blood transfusions during surgery. Mortality was nil. Pathological examination revealed 3 mucinous cystoadenocarcinomas, 36 mucinous cystadenomas, 28 serous cystadenomas, 14 solid pseudopapillary tumors, 3 IPMNs, 1 pancreatic pseudocyst, 1 adrenal pseudocyst, 1 acinar adenoma, 1 lymphangioma, 1 ciliated cyst, 1 simple cyst. The major morbidity rate was 13% and the minor morbidity rate was 31% (Clavien classification). Pancreatic fistulas developed in 27 patients (30%): 5 were classified as grade C, 6 as grade B, the others as grade A (ISGPF definition). A re-operation was required in 11 cases (12%), 4 due to post-operative hemorrhage, 5 due to sepsis from abdominal abscess, and 2 due to splenic infarction. In patients without complications, the median lenghtb od stay (LOS) was 7.5 days (range: 4-11 days); the ones with a complicated course had a median LOS of 11 days (range: 5-25 days). Conclusions This is the largest single centre series of laparoscopic surgery for cystic lesions in the English literature and confirms safety and feasibility. Robot assisted pancreatic resections is promising and deserves future larger application.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
The fate of non-trivial entanglement under gravitational collapse
Creators: name: Martin-Martinez, Eduardo
name: Garay, Luis J.
name: Leon, Juan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We analyse the evolution of the entanglement of a non-trivial initial quantum field state (which, for simplicity, has been taken to be a bipartite state made out of vacuum and the first excited state) when it undergoes a gravitational collapse. We carry out this analysis by generalising the tools developed to study entanglement behaviour in stationary scenarios and making them suitable to deal with dynamical spacetimes. We also discuss what kind of problems can be tackled using the formalism spelled out here as well as single out future avenues of research.
description: 9 pages, 2 figures. v2: Added Journal reference and small changes to match published version
The effect of curvature on convexity properties of harmonic functions and eigenfunctions
Creators: name: Mangoubi, Dan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics
subject: 35P20, 58J50 (Primary) 53C21, 35J15 (Secondary)

description: We give a proof of the Donnelly-Fefferman growth bound of Laplace-Beltrami eigenfunctions which is probably the easiest and the most elementary one. Our proof also gives new quantitative geometric estimates in terms of curvature bounds which improve and simplify previous work by Garofalo and Lin. The proof is based on a convexity property of harmonic functions on curved manifolds, generalizing Agmon's Theorem on a convexity property of harmonic functions in R^n.
description: 24 pages. This is a major revision. The main theorem now treats the case of pinched curvature between any two real values. The proof is simplified in several points. Ricci curvature is replaced by sectional curvature. Referee's remarks incorporated
Eucamenta Peringuey 1904
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Eucamenta

description: Eucamenta Péringuey, 1904, as Camenta (Eucamenta)
[2 species].
Type species Camenta (Eucamenta) transvaalensis Péringuey, 1904, by subsequent designation of Ahrens (2007a).
Status revised to Eucamenta by Dalla Torre (1912a).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 140, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Anti-VEGF Treatment-Resistant Pancreatic Cancers Secrete Proinflammatory Factors That Contribute to Malignant Progression by Inducing an EMT Cell Phenotype
Creators: name: Carbone, Carmine
name: Piro, Geny
name: Tamburrino, Anna
name: Mina, Maria Mihaela
name: Zanini, Silvia
name: Tortora, Giampaolo
name: Melisi, Davide
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context The resistance of tumors to antiangiogenic therapies is becoming increasingly relevant. There are currently no validated predictive biomarkers for selecting which cancer patients will benefit from antiangiogenic therapy. Also lacking are resistance biomarkers that can identify which escape pathways should be targeted after tumors develop resistance to VEGF treatment. Recent studies showed that anti-VEGF treatment can make tumor cells more aggressive and metastatic. However, the mechanisms and mediators of this are unidentified. Objective We aimed this study at directly identifying the tumor cell-initiated mechanisms responsible for the resistance of pancreatic cancer to anti-VEGF treatment. Methods We established and validated two murine models of human pancreatic cancer resistant to the VEGF-specific antibody bevacizumab in vivo. We used a genome-wide analysis to directly identify which tumor-secreted factors were overexpressed by pancreatic cancer cells that were resistant to anti-VEGF treatment. Results Rather than direct proangiogenic factors, we identified several proinflammatory factors that were expressed at higher levels in cells resistant to anti-VEGF treatment than in treatment-sensitive control cells. These proinflammatory factors acted in a paracrine manner to stimulate the recruitment of CD11b+ proangiogenic myeloid cells. Also, we found that secreted factors overexpressed by anti-VEGF treatment-resistant pancreatic cancer cells acted in an autocrine manner to induce epithelial-to-mesenchymal transition (EMT) and were thus responsible for increased aggressiveness of bevacizumab-resistant pancreatic tumors. Conclusions Our results identified proinflammatory factors and EMT markers as potential biomarkers for selecting patients with pancreatic cancer for antiangiogenic therapy.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
TGF-β-Activated Kinase 1 (TAK1) Is an In Vivo Druggable Target for Reverting Pancreatic Cancer Chemoresistance
Creators: name: Carbone, Carmine
name: Piro, Geny
name: Tamburrino, Anna
name: Mina, Maria Mihaela
name: Zanini, Silvia
name: Tortora, Giampaolo
name: Melisi, Davide
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context TAK1, a mitogen-activated protein kinase kinase kinase, functions in the activation of nuclear factor kappaB (NF-kappaB) and activator protein-1, which can suppress proapoptotic signaling pathways and thus promote resistance to chemotherapeutic drugs. However, it is not known if inhibition of TAK1 is effective in reducing chemoresistance to therapeutic drugs against pancreatic cancer. Methods: NF-kappaB activity was measured by luciferase reporter assay in human pancreatic cancer cell lines AsPc-1, PANC-1, and MDAPanc-28, in which TAK1 expression was silenced by small hairpin RNA. TAK1 kinase activity was targeted in AsPc-1, PANC-1, MDAPanc-28, and Colo357FG cells with exposure to increasing doses of a selective small-molecule inhibitor, LYTAK1, for 24 hours. To test the effect of LYTAK1 in combination with chemotherapeutic agents, AsPc-1, PANC-1, MDAPanc-28 cells, and control cells were treated with increasing doses of oxaliplatin, SN-38, or gemcitabine in combination with LYTAK1. In vivo activity of oral LYTAK1 was evaluated in an orthotopic nude mouse model (n=40, 5 per group) with luciferase-expressing AsPc-1 pancreatic cancer cells. Results AsPc-1 and MDAPanc-28 TAK1 knockdown cells had a statistically significantly lower NF-kappaB activity than did their respective control cell lines. TAK1 inhibitor LYTAK1 had potent in vitro cytotoxic activity in AsPc-1, PANC-1, MDAPanc-28, and Colo357FG cells, with IC50 between 5 and 40 nM. LYTAK1 also potentiated the cytotoxicity of chemotherapeutic agents oxaliplatin, SN-38, and gemcitabine in AsPc-1, PANC-1, and MDAPanc-28 cells compared with control cells. In nude mice, oral administration of LYTAK1 plus gemcitabine statistically significantly reduced tumor burden and prolonged survival duration. Conclusions The results of this study suggest that genetic silencing or inhibition of TAK1 kinase activity in vivo is a potential therapeutic approach to reversal of the intrinsic chemoresistance of pancreatic cancer.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
An atomic interface between microwave and optical photons
Creators: name: Hafezi, M.
name: Kim, Z.
name: Rolston, S. L.
name: Orozco, L. A.
name: Lev., B. L.
name: Taylor, J. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: A complete physical approach to quantum information requires a robust interface among flying qubits, long-lifetime memory and computational qubits. Here we present a unified interface for microwave and optical photons, potentially connecting engineerable quantum devices such as superconducting qubits at long distances through optical photons. Our approach uses an ultracold ensemble of atoms for two purposes: quantum memory and to transduce excitations between the two frequency domains. Using coherent control techniques, we examine an approach for converting and storing quantum information between microwave photons in superconducting resonators, ensembles of ultracold atoms, and optical photons as well as a method for transferring information between two resonators.
description: 5 pages, 3 figures
Gamka Peringuey 1904
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Gamka

description: Gamka Péringuey, 1904
[1 species].
Type species Gamka minuta Péringuey, 1904, by monotypy.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 140, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Influential, efficient, or both : does committee review of legislation matter in Westminster parliaments?
Creators: name: Whelan, Colin
Publisher: name: University of British Columbia
Year: 2013

description: This paper examines the legislative impact of committee review in Canadian provinces. Traditionally, legislation in Westminster systems has been scrutinized by a Committee of the Whole House. Today, four of Canada's ten provinces have moved this committee stage into the separate committee system. The British House of Commons and Canada's Federal Parliament have also made similar reforms. These reforms consistently received cross-party support, as reformers believed that the changes would both increase efficiency and also create more legislative influence for committees. I test for these effects by measuring both the ability of committees to amend legislation and the efficiency of the legislative process in Canada's provinces from 1983 to 2013. Results show that while legislation is amended more frequently when reviewed in the committee system, there are no measurable gains in efficiency. This finding has important implications for questions about legislative-executive balance and the effects of institutional reform in Westminster-style parliaments.
Random pinning limits the size of membrane adhesion domains
Creators: name: Speck, Thomas
name: Vink, Richard L. C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Theoretical models describing specific adhesion of membranes predict (for certain parameters) a macroscopic phase separation of bonds into adhesion domains. We show that this behavior is fundamentally altered if the membrane is pinned randomly due to, e.g., proteins that anchor the membrane to the cytoskeleton. Perturbations which locally restrict membrane height fluctuations induce quenched disorder of the random-field type. This rigorously prevents the formation of macroscopic adhesion domains following the Imry-Ma argument [Y. Imry and S. K. Ma, Phys. Rev. Lett. 35, 1399 (1975)]. Our prediction of random-field disorder follows from analytical calculations, and is strikingly confirmed in large-scale Monte Carlo simulations. These simulations are based on an efficient composite Monte Carlo move, whereby membrane height and bond degrees of freedom are updated simultaneously in a single move. The application of this move should prove rewarding for other systems also.
description: revised and extended version
The Outbreak of Multidrug-Resistant Klebsiella pneumoniae in a High Volume Pancreatic Surgery Unit
Creators: name: Malleo, Giuseppe
name: Germenia, Silvia
name: Marchegiani, Giovanni
name: Morelli, Eleonora
name: Maggino, Laura
name: Salvia, Roberto
name: Bassi, Claudio
name: Butturini, Giovanni
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context The threat of infections due to multidrug-resistant (MDR) gram-negative rods is increasing. In 2012, an outbreak of Klebsiella pneumoniae resistant to multiple antibiotics occurred in different units of the Verona Hospital Trust, including our pancreatic surgery unit. Objective. The aim of this study was to investigate the burden of the hospital outbreak on mortality after pancreatic resections performed in 2012. Furthermore, we assessed whether the mortality pattern changed in comparison with 2011. Methods During internal audits, an analysis of short-term outcomes of pancreatic resections performed over a 2-year period was undertaken. Results In 2012, 261 pancreatic resections (160 pancreatico­duodenectomies, 60 distal resections, 15 middle pancreatectomies, 16 total pancrea­tectomies, 10 enucleations) were carried out. Postoperative morbidity was 54.9%; abdominal complications rate was 46.3%; postoperative mortality was 2.3% (6 events). MDR Klebsiella pneumoniae was isolated in 11 patients (4.2%). Of these, 5 died post­operatively of sepsis, superimposed to a grade C pancreatic fistula after pancreaticoduodenectomy. The remaining post­operative death was due to a cardiac event. In 2011, 257 pancreatic resections were performed. No MDR Klebsiella pneumoniae was isolated. Postoperative morbidity was 51.0%, Abdominal complications rate was 43.7%, Postoperative mortality was 1.1% (3 cardiac events). The difference in mortality between 2012 and 2011 was not statistically significant (P=0.257). Conclusion Despite the difference in mortality between 2012 and 2011 was not statistically significant, the clinical impact of MDR Klebsiella pneumoniae on mortality after pancreatic resections was substantial. In particular, 5/11 of patients with MDR Klebsiella pneumoniae exhibited a very serious complication profile and eventually died of sepsis. In those who survived, hospital stay was prolonged, with increased cost. These results emphasize the need of appropriate measures to contain hospital outbreaks of MDR gram-negative strains, and of exhaustive patient information about nosocomial infections.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602
Metastability and anomalous fixation in evolutionary games on scale-free networks
Creators: name: Assaf, Michael
name: Mobilia, Mauro
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We study the influence of complex graphs on the metastability and fixation properties of a set of evolutionary processes. In the framework of evolutionary game theory, where the fitness and selection are frequency-dependent and vary with the population composition, we analyze the dynamics of snowdrift games (characterized by a metastable coexistence state) on scale-free networks. Using an effective diffusion theory in the weak selection limit, we demonstrate how the scale-free structure affects the system's metastable state and leads to anomalous fixation. In particular, we analytically and numerically show that the probability and mean time of fixation are characterized by stretched exponential behaviors with exponents depending on the network's degree distribution.
description: 5 pages, 4 figures, to appear in Physical Review Letters
Cohort Study of the Incidence of Extrapancreatic Neoplasm During Clinical and Radiological Surveillance of Patients with Branch-Duct IPMN
Creators: name: Borin, Alex
name: Malleo, Giuseppe
name: Marchegiani, Giovanni
name: Accordini, Federico
name: Marchese, Tiziana
name: Butturini, Giovanni
name: Bassi, Claudio
name: Salvia, Roberto
Publisher: name: JOP. Journal of the Pancreas
Year: 2013
Subjects: Meeting Abstracts; Pancreas

description: Context In the latest years, there has been controversy about the relationship between intraductal papillary mucinous neoplasms (IPMN) and the development of extrapancreatic neoplasms. While a number of prevalence studies confirmed this association, the only cohort studies available did not. Objective This is a cohort study of patients with branch-duct IPMN and without a personal history of other non-pancreatic neoplasms who were enrolled in a radiological surveillance protocol. The objective was to assess the incidence of extrapancreatic neoplasms during the follow-up period in comparison with that of the Italian general population. Methods Patients with well-documented branch-duct IPMN on cross-sectional imaging (MRI) and devoid of malignancy concern (according to an institutional protocol from 2000 until 2005 and to the IAP guidelines from 2005 and onwards) were enrolled in a radiological surveillance protocol on a yearly basis. The occurrence of other non-pancreatic neoplasms was recorded in a prospective database and the incidence was compared with the Italian tumor registry (AIRTUM). In particular, number of expected cases was calculated, and the standardized incidence ratio (observed/expected cases) with 95% CI was obtained. Risk function for the development of extrapancreatic neoplasms was then plotted according to the method of Kaplan and Meier. For the purposes of this study, follow-up was stopped on July 2013. Results Study population consisted of 472 patients observed over a 12-year period (2000-2012). Median follow-up was 44 months. Fifty-nine patients (12.5%) developed at least an extrapancreatic malignant neoplasm, for a total of 61 neoplastic events. Median time-to-presentation was 34 months. The most frequent neoplasms were breast cancer (n=15), renal clear cell carcinoma (n=7), colorectal cancer (n=5), melanoma (n=5), lung cancer (n=5), prostate cancer (n=4), and thyroid cancer (n=4). The cumulate incidence of extrapancreatic neoplasms in the study population was significantly greater than the expected incidence in the Italian population, with a standardized incidence ratio of 1.75 (95% CI: 1.33-2.26). According to the plotted risk function, the risk of developing a non-pancreatic neoplasm increased over time (1 year: 2%; 2 years: 4%; 5 years: 8%). Conclusion Patients with branch-duct IPMN have a 1.75 fold increase of non-pancreatic neoplasms during the follow-up period. This warrants sub-analyses by sex, age, type of neoplasm, and possible revision of follow-up protocols, with targeted tumor screening.
description: JOP. Journal of the Pancreas, Vol 14, N° 5S (2013): September (Suppl.) - p. 528-602