cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The universal C*-algebra of the electromagnetic field
Creators: name: Buchholz, Detlev
name: Ciolli, Fabio
name: Ruzzi, Giuseppe
name: Vasselli, Ezio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A universal C*-algebra of the electromagnetic field is constructed. It is represented in any quantum field theory which incorporates electromagnetism and expresses basic features of this field such as Maxwell's equations, Poincaré covariance and Einstein causality. Moreover, topological properties of the field resulting from Maxwell's equations are encoded in the algebra, leading to commutation relations with values in its center. The representation theory of the algebra is discussed with focus on vacuum representations, fixing the dynamics of the field.
description: 17 pages, 1 figure; v2: minor corrections, version as to appear in Lett. Math. Phys. Dedicated to the memory of D. Kastler and J.E. Roberts; v3 improvement of layout
Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?
Creators: name: Pan, Maxwell
name: Brouwer, Kim L.R.
name: Lu, Yang
name: Brock, William J.
name: Slizgi, Jason R.
name: St. Claire, Robert L.
name: Freeman, Kimberly M.
name: Brouwer, Kenneth R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Tolvaptan is a vasopressin V
Control of Exciton Transport using Quantum Interference
Creators: name: Lusk, Mark T.
name: Stafford, Charles
name: Zimmerman, Jeramy D.
name: Carr, Lincoln D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: It is shown that quantum interference can be employed to create an exciton transistor. An applied potential gates the quasi-particle motion and also discriminates between quasi-particles of differing binding energy. When implemented within nanoscale assemblies, such control elements could mediate the flow of energy and information. Quantum interference can also be used to dissociate excitons as an alternative to using heterojunctions. A finite molecular setting is employed to exhibit the underlying discrete, two-particle, mesoscopic analog to Fano anti-resonance. Selected entanglement measures are shown to distinguish regimes of behavior which cannot be resolved from population dynamics alone.
description: 5 pages, 5 figures
Le balene sconfiggono i confini. Appunti per una narrazione fra storie familiari e spazi urbani
Creators: name: Tosi Cambini, Sabrina
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The article is an ethnographic text and it concerns those people that the society defines “marginal”, “excluded” or “poor”; notions used in a critical approach. The narrative discourse used is the expression of the narrative mode of thinking that «deals - Bruner writes - in human or human-like intention an action and the vicissitudes and consequences that mark their course. It strives to put its timeless miracles into the particulars of experience and to locate the experience in time and place» (1986, Actual minds, possible words, Cambridge, Mass.: Harvard University Press). The fragments of the family histories are placed in specific urban spaces and temporality related to immigration, immersed in the city and connected to the right to housing, speculative property interests, and policies.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 2 No. 3 (2012)
DID COVID-19 PANDEMIC AFFECT THE FINANCIAL PERFORMANCE OF THE COMPANIES AWFULLY?
Creators: name: Eeshita Goyal1   Prof. L. N. Koli 2
Publisher: name: Zenodo
Year: 2022
Subjects: Financial Performance, Covid-19, Tata Group, Return on Assets, Receivables Turnover.

description: Abstract- Whole economy was negatively affected, and as well as all companies have a huge impact of Covid-19 pandemic on the financial performance. This pandemic has affected globally and put a strain but this pandemic has also given many new opportunities to the companies to become more digitalize. To analyses the financial performance of before and during Covid-19 period 22 Tata Group Companies which are listed in Nifty Stock Exchange have been selected. The Normality Test, Kolmogorov-Smirnova, Shapiro-Wilk and Wilcoxon Signed Rank Test was performed to test the difference between some selected ratios in 2019- 22. The objective of the study was to calculate and analyze Return on Asset, Receivable Turnover, Current Ratio, Leverage ratio.To compare the financial performance of selected Tata Group companies of before covid-19 and during Covid-19 period and to analyze the impact of pandemic on the companies financial performance of selected Tata Group companies. This study found that the financial performance of 22 Tata Group Companies listed on the National stock exchange has improved. The analysis shows that all the ratios return on asset, leverage ratio, current ratio and receivables turnover all have increased before and during Covid-19 period.
Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair
Creators: name: Serafin, Aleksandra
name: Rubio, Mario Culebras
name: Carsi, Marta
name: Ortiz-Serna, Pilar
name: Sanchis, Maria J.
name: Garg, Atul K.
name: Oliveira, J. Miguel
name: Kofer, Jacob
name: COLLINS, MAURICE
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 40
subject: Engineering

description: Background: Hostile environment around the lesion site following spinal cord injury (SCI) prevents the re-establish‑ ment of neuronal tracks, thus significantly limiting the regenerative capability. Electroconductive scaffolds are emerging as a promising option for SCI repair, though currently available conductive polymers such as polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) present poor bio-functionality and biocompatibility, thus limiting their effective use in SCI tissue engineering (TE) treatment strategies. Methods: PEDOT NPs were synthesized via chemical oxidation polymerization in miniemulsion. The conductive PEDOT NPs were incorporated with gelatin and hyaluronic acid (HA) to create gel:HA:PEDOT-NPs scaffolds. Morpho‑ logical analysis of both PEDOT NPs and scafolds was conducted via SEM. Further characterisation included dielectric constant and permittivity variances mapped against morphological changes after crosslinking, Young’s modulus, FTIR, DLS, swelling studies, rheology, in-vitro, and in-vivo biocompatibility studies were also conducted. Results: Incorporation of PEDOT NPs increased the conductivity of scafolds to 8.3× 10–4±8.1× 10–5 S/cm. The com pressive modulus of the scafold was tailored to match the native spinal cord at 1.2±0.2 MPa, along with controlled porosity. Rheological studies of the hydrogel showed excellent 3D shear-thinning printing capabilities and shape fdelity post-printing. In-vitro studies showed the scafolds are cytocompatible and an in-vivo assessment in a rat SCI lesion model shows glial fbrillary acidic protein (GFAP) upregulation not directly in contact with the lesion/implantation site, with diminished astrocyte reactivity. Decreased levels of macrophage and microglia reactivity at the implant site is also observed. This positively influences the re-establishment of signals and initiation of healing mechanisms. Observation of axon migration towards the scaffold can be attributed to immunomodulatory properties of HA in the scaffold caused by a controlled inflammatory response. HA limits astrocyte activation through its CD44 receptors and therefore limits scar formation. This allows for a superior axonal migration and growth towards the targeted implantation site through the provision of a stimulating microenvironment for regeneration. Conclusions: Based on these results, the incorporation of PEDOT NPs into Gel:HA biomaterial scaffolds enhances not only the conductive capabilities of the material, but also the provision of a healing environment around lesions in SCI. Hence, gel:HA:PEDOT-NPs scaffolds are a promising TE option for stimulating regeneration for SCI.
Averrhoidium paraguaiense Radlk.
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Sapindaceae
Averrhoidium
Averrhoidium paraguaiense

description: Averrhoidium paraguaiense Radlk.
Distribution: Bolivia (?), Brazil, Paraguay.
 Source: Jørgensen et al. 2014 (Preliminary identification based in a sterile, juvenile specimen), Somner et al. 2015.
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Figlie dell'era Ceausescu: il caso studio delle interruzioni volontarie di gravidanza tra le donne rumene ad Arezzo
Creators: name: Tizzi, Giovanna
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The following research explores the voluntary interruption of pregnancy (abortion patterns - IVG) of immigrant Romanian women in the province of Arezzo. The study compared fertility, abortion and pregnancy rates and contraceptive prevalence before and after a change in Romanian government policy that legalized abortion and modern contraception. It then focuses on the concept of family planning among Romanian immigrants in Arezzo, where an extremely high rate of abortion appears to be the principal determinant of control of pregnancies. The key questions are: what are the motivations that move the Romanian women to such high percentages to the IVG? What social and individual factors affect this the most? In addition to the individual motivations and socioeconomic characteristics of applicants IVG, what are the social elements related to the migratory experience? The research examines the characteristics of context of the “place of origin” (the socio-political climate in terms of reproductive health) and “arrival” context (biographical trajectories, life contexts, roles, and social relations). The research plan is structured around a multidimensional model, and examines the different elements that have an influence on the IVG question. Methodological instruments used include secondary analysis, survey, biographical interviews, focus groups with consultancy service operators (gynecologists, midwives, social workers, nurses, psychologists and health services managers) and participant observation.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 2 No. 3 (2012)
Supplement: Expanded section on funding options to help caregivers from Sticky steps and the gender gap: how thoughtful practices could help keep caregivers in science
Creators: name: Meirmans, Stephanie
name: Lamatsch, Dunja K.
name: Neiman, Maurine
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Many fewer women than men hold senior academic positions, a widely recognized and increasing problem. Our goal is to identify effective and feasible solutions. We begin by providing an in-depth assessment of the drivers of this gender inequity. In our synthesis of existing data, we provide many lines of evidence highlighting caregiving as a primary main factor. This is not a ‘new’ insight per se, but a point worth repeating that we back up by a strong and synthetic body of recent data. We also believe that our analysis provides a step forward in simplifying a complex issue. We then develop a more detailed understanding of the challenges academic caregivers face and discuss whether and why it is important to keep caregivers in science. We find that the attrition due to caregiving should not be seen as a factor but rather as a process with multiple ‘sticky steps’ that eventually drive caregivers out of science—which, as we argue, is partly also good news. Indeed, it is here that we believe actions could be taken that would have a real impact: for example, one could effectively increase and expand upon current funding practices that focus on caregiver career advancement.
Massey products in differential cohomology via stacks
Creators: name: Grady, Daniel
name: Sati, Hisham
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Topology (math.AT)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We extend Massey products from cohomology to differential cohomology via stacks, organizing and generalizing existing constructions in Deligne cohomology. We study the properties and show how they are related to more classical Massey products in de Rham, singular, and Deligne cohomology. The setting and the algebraic machinery via stacks allow for computations and make the construction well-suited for applications. We illustrate with several examples from differential geometry and mathematical physics.
description: 50 pages, improved presentation and many corrections, published version
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Creators: name: Mosedale, Merrie
name: Holman, Natalie S.
name: LeCluyse, Edward L.
name: Watkins, Paul B.
name: Wolf, Kristina K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed hepatocytes can trigger immune responses that may be common across DILI mechanisms. Extracellular vesicles released by hepatocytes, principally hepatocyte-derived exosomes (HDEs), may constitute one such signal. To examine HDE alterations as a function of drug-induced stress, this work utilized prototypical hepatotoxicant acetaminophen (APAP) in male Sprague-Dawley (SD) rats, SD rat hepatocytes, and primary human hepatocytes. HDE were isolated using ExoQuick precipitation reagent and analyzed by quantification of the liver-specific RNAs albumin and microRNA-122 (miR-122). In vivo, significant elevations in circulating exosomal albumin mRNA were observed at subtoxic APAP exposures. Significant increases in exosomal albumin mRNA were also observed in primary rat hepatocytes at subtoxic APAP concentrations. In primary human hepatocytes, APAP elicited increases in both exosomal albumin mRNA and exosomal miR-122 without overt cytotoxicity. However, the number of HDE produced in vitro in response to APAP did not increase with exosomal RNA quantity. We conclude that significant drug-induced alterations in the liver-specific RNA content of HDE occur at subtoxic APAP exposures in vivo and in vitro, and that these changes appear to reflect selective packaging rather than changes in exosome number. The current findings demonstrate that translationally relevant HDE alterations occur in the absence of overt hepatocellular toxicity, and support the hypothesis that HDE released by stressed hepatocytes may mediate early immune responses in DILI.
Energy states of some diatomic molecules: Exact quantization rule approach
Creators: name: Falaye, Babatunde. J.
name: Ikhdair, Sameer M.
name: Hamzavi, Majid
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this study, we obtain the approximate analytical solutions of the radial Schrödinger equation for the Deng-Fan diatomic molecular potential by using exact quantization rule approach. The wave functions have been expressed by hypergeometric functions via the functional analysis approach. An extension to rotational-vibrational energy eigenvalues of some diatomic molecules are also presented. It is shown that the calculated energy levels are in good agreement with the ones obtained previously $E_{n\ell}-D$ (shifted Deng-Fan).
Kalibrierung von Beschleunigungsmessgeräten nach dem Vergleichsverfahren : Richtlinie DKD-R 3-1 Blatt 2
Creators: name: Physikalisch-Technische Bundesanstalt, Braunschweig
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2019
Subjects: Beschleunigung
Stoßanregung
Kalibrierung
DKD-Richtlinie
Fassung 2019

description: Diese Richtlinie geht auf Kalibrierverfahren ein, bei denen eine stoßförmige Beschleunigung mit einem Hammer-Amboss-System erzeugt wird. Sie gilt für die Kalibrierung von Beschleunigungsmessgeräten, die einen seismischen Aufnehmer beinhalten. Seismische Aufnehmer besitzen eine seismische Masse, die über ein nachgiebiges und u. U. ein dämpfendes Element mit einem Gehäuse verbunden ist und die in einem bestimmten Frequenzbereich proportional zu einer einwirkenden Beschleunigung ausgelenkt wird. Diese Auslenkung wird häufig durch Änderung von Widerständen, Kapazitäten und Induktivitäten oder durch Nutzung des piezoelektrischen Effekts in ein elektrisches Signal umgewandelt. Voraussetzung für die Stoßkalibrierung ist eine ausreichend hohe Resonanzfrequenz des Aufnehmers. Bei Kalibriergegenständen, über die keine Informationen des Frequenzverhaltens vorliegen, sollte vor der Kalibrierung eine Frequenzgangbestimmung vorgenommen werden. Die Richtlinie ergänzt Forderungen der ISO 16063-22 um Hinweise für den Umgang mit Kalibriereinrichtungen für Stoßanregung und beschreibt Kalibrierabläufe. Die Richtlinie beschränkt sich auf die Bestimmung des Stoß-Übertragungskoeffizienten von Beschleunigungsaufnehmern und -messketten, definiert als Verhältnis des Spitzenwertes der Ausgangsgröße (elektrische Spannung oder Ladung) zum Spitzenwert der Anregungsbeschleunigung.
Intertial Frame Dragging in an Acoustic Analogue spacetime
Creators: name: Chakraborty, Chandrachur
name: Ganguly, Oindrila
name: Majumdar, Parthasarathi
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Other Condensed Matter (cond-mat.other)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We report an incipient exploration of the Lense-Thirring precession effect in a rotating \textit{acoustic analogue black hole} spacetime. An exact formula is deduced for the precession frequency of a gyroscope due to inertial frame dragging, close to the ergosphere of a `Draining Bathtub' acoustic spacetime which has been studied extensively for acoustic Hawking radiation of phonons and also for `superresonance'. The formula is verified by embedding the two dimensional spatial (acoustic) geometry into a three dimensional one where the similarity with standard Lense-Thirring precession results within a strong gravity framework is well known. Prospects of experimental detection of this new `fixed-metric' effect in acoustic geometries, are briefly discussed.
description: LaTex; 6 pages including 1 figure; paper thoroughly revised, accepted for publication in Annalen der Physik
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors
Creators: name: Shoda, Lisl K.M.
name: Brock, William J.
name: Mosedale, Merrie
name: Woodhead, Jeffrey L.
name: Brouwer, Kim L.R.
name: Stiles, Linsey
name: Shoaf, Susan E.
name: Siler, Scott Q.
name: Roth, Sharin E.
name: Howell, Brett A.
name: Watkins, Paul B.
name: Church, Rachel
name: Grammatopoulos, Tom N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). No liver injury has been observed with tolvaptan treatment in healthy subjects and in non-ADPKD indications, but ADPKD clinical trials showed evidence of drug-induced liver injury (DILI). Although all DILI events resolved, additional monitoring in tolvaptan-treated ADPKD patients is required. In vitro assays identified alterations in bile acid disposition and inhibition of mitochondrial respiration as potential mechanisms underlying tolvaptan hepatotoxicity. This report details the application of DILIsym software to determine whether these mechanisms could account for the liver safety profile of tolvaptan observed in ADPKD clinical trials. DILIsym simulations included physiologically based pharmacokinetic estimates of hepatic exposure for tolvaptan and2 metabolites, and their effects on hepatocyte bile acid transporters and mitochondrial respiration. The frequency of predicted alanine aminotransferase (ALT) elevations, following simulated 90/30 mg split daily dosing, was 7.9% compared with clinical observations of 4.4% in ADPKD trials. Toxicity was multifactorial as inhibition of bile acid transporters and mitochondrial respiration contributed to the simulated DILI. Furthermore, simulation analysis identified both pre-treatment risk factors and on-treatment biomarkers predictive of simulated DILI. The simulations demonstrated that in vivo hepatic exposure to tolvaptan and the DM-4103 metabolite, combined with these 2 mechanisms of toxicity, were sufficient to account for the initiation of tolvaptan-mediated DILI. Identification of putative risk-factors and potential novel biomarkers provided insight for the development of mechanism-based tolvaptan risk-mitigation strategies.
Medici e manager. Verso un nuovo professionalismo?
Creators: name: Vicarelli, Giovanna
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: The blend of doctors’ and managers’ tasks is the result of a conflict that lasted for several decades and have not yet reached its end. However today, this fusion is proposed as evidence, as long as becoming a unions claims. What has happened in this time frame, and how it can explain the current figure of doctor with managerial skills as well professional skills? We are facing a new medical professionalism? To understand these transformations is necessary to reconstruct the path that, in Italy, led the interdependence between current professional knowledge and knowledge management, trying to reason about the theoretical tools available (or in costruction) today to read the emerging configurations of health care.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 2 No. 3 (2012)
Sono equidistanti le categorie di una scala Likert? Alcune risultanze di ricerca
Creators: name: Marradi, Alberto
name: Macrì, Ester
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: One obvious, minimal pre-requisite in order to use Likert scores as cardinal numbers in data analysis is that they be perceived as more or less equidistant along the dimension of interest. Already 50 years ago, Johann Galtung among others raised serious doubts about the possibility that respondents actually do consider “agree” and “disagree” as equidistant from “uncertain”, given the well-known frequency of acquiescent response sets. In 1973, Benzecri maintained that the technique he had just launched on the academic market (correspondence analysis) supplied an excellent means to also control the assumption of equidistance of one of Likert’s short answers from the two adjoining ones. In the nineties, three young Italian students applied Benzecri’s technique to three different samples of respondents, and found converging results, all widely apart from the assumed equidistance. This essay replicates their survey on a larger sample of Likert scales coming from a dozen different surveys. Unlike the previous controls, the results diverge largely from one another. Yet, only a few offer a mild support to the assumption of perceived equidistance, while in their majority the results raise all sorts of further doubts about it.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 2 No. 3 (2012)
Test for exotic isoscalar resonance dominating $D^0 \to π^+ π^- π^0$ decays
Creators: name: Gronau, Michael
name: Rosner, Jonathan L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The decay $D^0 \to π^+ π^- π^0$ appears to be dominated by $ρπ$ states in a configuration of zero total isotopic spin. The spin $J$, parity $P$, and charge-conjugation eigenvalue $C$ of this final state are therefore $J^{PC} = 0^{--}$, which cannot be formed of a quark $q$ and antiquark $\bar q$. If a resonance near $M(D^0)$ dominates the final state, it must be a {\it hybrid} composed of a quark-antiquark pair and a constituent gluon, or a {\it tetraquark} $q q \bar q \bar q$. A test for this resonance in electroproduction is proposed.
description: 11 pages, 3 figures. References, figures, and text added. Version to be published in Phys. Rev. D
Some explicit solutions of c-optimal design problems for polynomial regression
Creators: name: Dette, Holger
name: Melas, Viatcheslav B.
name: Shpilev, Petr
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: polynomial regression
subject: c-optimal designs
subject: slope estimation
subject: extrapolation
subject: 310
subject: 330
subject: 620

description: In this paper we consider the optimal design problem for extrapolation and estimation of the slope at a given point, say z, in a polynomial regression with no intercept. We provide explicit solutions of these problems in many cases and characterize those values of z, where this is not possible.
description: Discussion Paper / SFB823;8/2019
Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach
Creators: name: Wiltshire, Tim
name: Keele, Gregory R.
name: Brock, William J.
name: Roth, Sharin E.
name: Mosedale, Merrie
name: Valdar, William
name: Watkins, Paul B.
name: Eaddy, J. Scott
name: Corty, Robert W.
name: Kim, Yunjung
name: Xie, Yuying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Clinical trials of tolvaptan showed it to be a promising candidate for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) but also revealed potential for idiosyncratic drug-induced liver injury (DILI) in this patient population. To identify risk factors and mechanisms underlying tolvaptan DILI, 8 mice in each of 45 strains of the genetically diverse Collaborative Cross (CC) mouse population were treated with a single oral dose of either tolvaptan or vehicle. Significant elevations in plasma alanine aminotransferase (ALT) were observed in tolvaptan-treated animals in 3 of the 45 strains. Genetic mapping coupled with transcriptomic analysis in the liver was used to identify several candidate susceptibility genes including epoxide hydrolase 2, interferon regulatory factor 3, and mitochondrial fission factor. Gene pathway analysis revealed that oxidative stress and immune response pathways were activated in response to tolvaptan treatment across all strains, but genes involved in regulation of bile acid homeostasis were most associated with tolvaptan-induced elevations in ALT. Secretory leukocyte peptidase inhibitor (Slpi) mRNA was also induced in the susceptible strains and was associated with increased plasma levels of Slpi protein, suggesting a potential serum marker for DILI susceptibility. In summary, tolvaptan induced signs of oxidative stress, mitochondrial dysfunction, and innate immune response in all strains, but variation in bile acid homeostasis was most associated with susceptibility to the liver response. This CC study has indicated potential mechanisms underlying tolvaptan DILI and biomarkers of susceptibility that may be useful in managing the risk of DILI in ADPKD patients.
Amphipetalum paraguayense Bacigalupo
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Caryophyllales
Talinaceae
Amphipetalum
Amphipetalum paraguayense

description: Amphipetalum paraguayense Bacigalupo
Distribution: Bolivia, Paraguay.
 Source: Jørgensen et al. 2014.
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Mobile Privacy and Apps: Investigating User Behavior and Attitude
Creators: name: Havelka, Stefanie
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: mobile privacy
subject: privacy
subject: apps
subject: mobile devices
subject: user behavior
subject: attitude
subject: United States
subject: Germany
subject: library and information science students
subject: ethnography
subject: 020 Bibliotheks- und Informationswissenschaft

description: My dissertation investigates privacy as it relates to user behavior and attitude on mobile devices. I will examine how users’ understanding of mobile privacy differs from culture to culture. More specifically, I will use ethnographic methodologies to compare US and German library/information science students.
Development and Evaluation of a MOOC Extension for Teaching Subject-Specific Skills in Information Literacy for Business Administration
Creators: name: Dreisiebner, Stefan
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: information literacy
subject: MOOC
subject: subject-specific skills
subject: business administration
subject: 020 Bibliotheks- und Informationswissenschaft

description: Information Literacy (IL) is “the set of integrated abilities encompassing the reflective discovery of information, the understanding of how information is produced and valued, and the use of information in creating new knowledge and participating ethically in communities of learning” (American Library Association, 2016). IL as a social key competence is particularly essential in post-secondary education and research. According to many studies (e.g. Katz, 2007; Rubinić et al., 2013), student’s information literacy levels are generally low. IL also includes subject-specific skills; e.g. relevant resources are different among disciplines (Johnston & Webber, 2003; Bundy, 2004). Analyses show the need for an attractive tutorial which can be developed on a broad basis of available material. Accordingly, an extension to a Massive Open Online Course (MOOC) for developing information literacy focusing on higher education students shall be developed and evaluated, that focuses on information skills needed in Business Administration. MOOCs are online courses with no entry barriers open for unlimited participation (van Treek et al., 2013).
Investigation into the role of the Laurent property in integrability
Creators: name: Mase, Takafumi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the Laurent property for autonomous and nonautonomous discrete equations. First we show, without relying on the caterpillar lemma, the Laurent property for the Hirota-Miwa and the discrete BKP equations. Next we introduce the notion of reductions and gauge transformations for discrete bilinear equations and we prove that these preserve the Laurent property. Using these two techniques, we obtain the explicit condition on the coefficients of a nonautonomous discrete bilinear equation for it to possess the Laurent property. Finally we study the denominators of the iterates of an equation with the Laurent property and we show that any reduction to a mapping on a one-dimensional lattice of a nonautonomous Hirota-Miwa equation or discrete BKP equation, with the Laurent property, has zero algebraic entropy.
High-Throughput Screening Data Interpretation in the Context of In Vivo Transcriptomic Responses to Oral Cr(VI) Exposure
Creators: name: Ring, Caroline L.
name: Haws, Laurie C.
name: Rager, Julia E.
name: Fry, Rebecca C.
name: Thompson, Chad M.
name: Proctor, Deborah M.
name: Harris, Mark A.
name: Suh, Mina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The toxicity of hexavalent chromium [Cr(VI)] in drinking water has been studied extensively, and available in vivo and in vitro studies provide a robust dataset for application of advanced toxicological tools to inform the mode of action (MOA). This study aimed to contribute to the understanding of Cr(VI) MOA by evaluating high-throughput screening (HTS) data and other in vitro data relevant to Cr(VI), and comparing these findings to robust in vivo data, including transcriptomic profiles in target tissues. Evaluation of Tox21 HTS data for Cr(VI) identified 11 active assay endpoints relevant to the Ten Key Characteristics of Carcinogens (TKCCs) that have been proposed by other investigators. Four of these endpoints were related to TP53 (tumor protein 53) activation mapping to genotoxicity (KCC#2), and four were related to cell death/proliferation (KCC#10). HTS results were consistent with other in vitro data from the Comparative Toxicogenomics Database. In vitro responses were compared to in vivo transcriptomic responses in the most sensitive target tissue, the duodenum, of mice exposed to ≤ 180 ppm Cr(VI) for 7 and 90 days. Pathways that were altered both in vitro and in vivo included those relevant to cell death/proliferation. In contrast, pathways relevant to p53/DNA damage were identified in vitro but not in vivo. Benchmark dose modeling and phenotypic anchoring of in vivo transcriptomic responses strengthened the finding that Cr(VI) causes cell stress/injury followed by proliferation in the mouse duodenum at high doses. These findings contribute to the body of evidence supporting a non-mutagenic MOA for Cr(VI)-induced intestinal cancer.
Advance praise (as on the back cover of the book)
Creators: name: Klaassen, F.
name: Magnus, Jan R.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2023
Subjects: Social Science

description: Advance praise by Martina Navratilova, Lord Mervyn King, Geoff Pollard, Richard Blundell, Carl Morris, Peter C.B. Phillips, and Hal Stern.
Normalizability analysis of the generalized quantum electrodynamics from the causal point of view
Creators: name: Bufalo, R.
name: Pimentel, B. M.
name: Soto, D. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The causal perturbation theory is an axiomatic perturbative theory of the S-matrix. This formalism has as its essence the following axioms: causality, Lorentz invariance and asymptotic conditions. Any other property must be showed via the inductive method order-by-order and, of course, it depends on the particular physical model. In this work we shall study the normalizability of the generalized quantum electrodynamics in the framework of the causal approach. Furthermore, we analyse the implication of the gauge invariance onto the model and obtain the respective Ward-Takahashi-Fradkin identities.
description: V2: 32 pages, affiliations updated, published version
The merger and assembly histories of Milky Way- and M31-like galaxies with TNG50: disk survival through mergers
Creators: name: Sotillo-Ramos, Diego
name: Pillepich, Annalisa
name: Donnari, Martina
name: Nelson, Dylan
name: Eisert, Lukas
name: Rodriguez-Gomez, Vicente
name: Joshi, Gandhali
name: Vogelsberger, Mark
name: Hernquist, Lars
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We analyze the merger and assembly histories of Milky Way (MW) and Andromeda (M31)-like galaxies to quantify how, and how often, disk galaxies of this mass can survive recent major mergers (stellar mass ratio $\ge$ 1:4). For this, we use the cosmological magneto-hydrodynamical simulation TNG50 and identify 198 analog galaxies, selected based on their $z=0$ stellar mass ($10^{10.5-11.2} {\rm M_{\odot}}$), disky stellar morphology and local environment. Firstly, major mergers are common: 85 per cent (168) of MW/M31-like galaxies in TNG50 have undergone at least one major merger across their lifetime. In fact, 31 galaxies (16 per cent) have undergone a recent major merger, i.e. in the last 5 Gyr. The gas available during the merger suffices to either induce starbursts at pericentric passages or to sustain prolonged star formation after coalescence: in roughly half of the cases, the pre-existing stellar disk is destroyed because of the merger but reforms thanks to star formation. Moreover, higher merger mass ratios are more likely to destroy the stellar disks. In comparison to those with more ancient massive mergers, MW/M31-like galaxies with recent major mergers have, on average, somewhat thicker stellar disks, more massive and somewhat shallower stellar haloes, larger stellar ex-situ mass fractions, but similarly massive kinematically-defined bulges. All this is qualitatively consistent with the different observed properties of the Galaxy and Andromeda and with the constraints on their most recent major mergers, 8-11 and ~2 Gyr ago, respectively. According to contemporary cosmological simulations, a recent quiet merger history is not a pre-requisite for obtaining a relatively-thin stellar disk at $z=0$.
description: Published by MNRAS. Check also Chen et al., Engler et al. and Ramesh et al., on arxiv.org today, for further analyses of Milky Way- and Andromeda-like galaxies using the cosmological simulation TNG50. Main figures: 2, 7, 16
Twistor form of massive 6D superparticle
Creators: name: Routh, Alasdair J.
name: Townsend, Paul K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The massive six-dimensional (6D) superparticle with manifest (n,0) supersymmetry is shown to have a supertwistor formulation in which its "hidden" (0,n) supersymmetry is also manifest. The mass-shell constraint is replaced by Spin(5) spin-shell constraints which imply that the quantum superparticle has zero superspin, for n=1 it propagates the 6D Proca supermultiplet.
description: 16 pages. Revision corrects typos, adds references and improves discussion section. Minor corrections in v.3
How Likely are Constituent Quanta to Initiate Inflation?
Creators: name: Berezhiani, Lasha
name: Trodden, Mark
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We propose an intuitive framework for studying the problem of initial conditions in slow-roll inflation. In particular, we consider a universe at high, but sub-Planckian energy density and analyze the circumstances under which it is plausible for it to become dominated by inflated patches at late times, without appealing to the idea of self-reproduction. Our approach is based on defining a prior probability distribution for the constituent quanta of the pre-inflationary universe. To test the idea that inflation can begin under very generic circumstances, we make specific -- yet quite general and well grounded -- assumptions on the prior distribution. As a result, we are led to the conclusion that the probability for a given region to ignite inflation at sub-Planckian densities is extremely small. Furthermore, if one chooses to use the enormous volume factor that inflation yields as an appropriate measure, we find that the regions of the universe which started inflating at densities below the self-reproductive threshold nevertheless occupy a negligible physical volume in the present universe as compared to those domains that have never inflated.
description: 13 pages
The X(Disciplinarity) of Information Science
Creators: name: Balck, Sandra
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: history of sciences
subject: interdisciplinarity
subject: transdisciplinarity
subject: multidisciplinarity
subject: disciplinarity
subject: 020 Bibliotheks- und Informationswissenschaft

description: The Master Thesis deals with the x-disciplinarity of information science, as it is considered as a multi-, inter- or transdisciplinary discipline in the discourse of this subject. But what in particular do these concepts mean and how are they specifically differentiated from each other? The thesis introduces the concept of disciplinarity with a historical approach and presents the development of different cooperation concepts (multi-, trans-, interdisciplinarity) as well as of the concept of transscience (Transwissenschaft). The disciplinarity of information science is analyzed on a communicational, social and cognitive level. Beside the definition of the term “information”, the paradigmatic development of information science is drafted, followed by an evaluation of relevant publications and an application of the different concepts of disciplinarity to information science. It is concluded, on the basis of a critical analysis, that real collaboration within the discipline is needed instead of blurry labels.
Linking the Epigenome with Exposure Effects and Susceptibility: The Epigenetic Seed and Soil Model
Creators: name: McCullough, Shaun D.
name: Bowers, Emma C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The epigenome is a dynamic mediator of gene expression that shapes the way that cells, tissues, and organisms respond to their environment. Initial studies in the emerging field of “toxicoepigenetics” have described either the impact of an environmental exposure on the epigenome or the association of epigenetic signatures with the onset or progression of disease; however, the majority of these pioneering studies examined the relationship between discrete epigenetic modifications and the effects of a single environmental factor. Although these data provide critical blocks with which we construct our understanding of the role of the epigenome in susceptibility and disease, they are akin to individual letters in a complex alphabet that is used to compose the language of the epigenome. Advancing the use of epigenetic data to gain a more comprehensive understanding of the mechanisms underlying exposure effects, identify susceptible populations, and inform the next generation risk assessment depends on our ability to integrate these data in a way that accounts for their cumulative impact on gene regulation. Here we will review current examples demonstrating associations between the epigenetic impacts of intrinsic factors, such as such as age, genetics, and sex, and environmental exposures shape the epigenome and susceptibility to exposure effects and disease. We will also demonstrate how the “epigenetic seed and soil” model can be used as a conceptual framework to explain how epigenetic states are shaped by the cumulative impacts of intrinsic and extrinsic factors and how these in turn determine how an individual responds to subsequent exposure to environmental stressors.
Monmouth University/Asbury Park Press Poll: September 2014
Creators: name: Asbury Park Press
name: Monmouth University Polling Institute
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: New Jersey as place to live (1); Governor Chris Christie job performance (1); NJ State Legislature job performance (1); President Barack Obama job performance (1); US Senator Bob Menendez job performance (1); US Senator Cory Booker job performance (1); Affordable Care Act (ACA), Obamacare favorability (1); Christie more concerned about governing state/his political future (1); NJ pension system (3); George Washington Bridge toll lane closures in Fort Lee (2); Christie's visited Mexico to build trade relations between Mexico and NJ/to help possible presidential run (1); Christie is/is not planning to run for president in 2016 (1); effect of Christie's travel schedule and possible presidential run on performance as governor (1); respondent's town, city as place to live (1); local environmental quality (1); local school quality (1); neighborhood safety (1); Superstorm Sandy recovery (4); preparations for next big storm (2); visiting the Jersey Shore (2); respondent or someone respondent knows displaced from home for more month a month due to Superstorm Sandy (1); red light cameras (9); would like to move out of NJ at some point/stay in NJ for rest of life (1); moving out of NJ (3); retirement age (1); concern about not having enough money for retirement (1); Bruce Springsteen (7).
Between Social "Forms" and "Figurational" Sociology: Simmel and Elias and the Role of Emotions
Creators: name: Bianchi, Francesca
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2016

description: Cambio. Rivista sulle Trasformazioni Sociali, Vol. 1 No. 2 (2011)
Neutrino Sector and Proton Lifetime in a Realistic SUSY SO(10) Model
Creators: name: Severson, Matthew
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work I present a full analysis of proton decay in an $SO(10)$ model previously proposed by Dutta, Mimura, and Mohapatra. The $\bf{10}$, $\overline{\bf{126}}$, and $\bf{120}$ Yukawa couplings contributing to fermion masses in this model have well-motivated restrictions on their textures intended to give favorable results for proton lifetime as well as a realistic fermion sector without the need for fine-tuning and for either type-I or type-II dominance in the neutrino mass matrix. I obtain a valid fit for the entire fermion sector for both types of seesaw dominance, including $θ_{13}$ in good agreement with the most recent data. For the case with type-II seesaw, I find that using the Yukawa couplings fixed by the successful fermion sector fit, proton partial lifetime limits are satisfied for nearly every pertinent decay mode, even for nearly arbitrary values of the triplet Higgs mixing parameters, with only the $K^+ \barν$ mode requiring a minor ${\cal O}(10^{-1})$ cancellation in order to satisfy the experimental limit. I also find a maximum lifetime for that mode of $τ(K^+ \barν) \sim 10^{36}$ years, which should be tested by eventual experiments. For the type-I seesaw case, I find that all six pertinent decay modes of interest are satisfied for values of the triplet mixing parameters giving no major enhancement, with modes other than $K^+ \barν$ easily satisfied for arbitrary mixing values, and with a maximum lifetime for $K^+ \barν$ of nearly $10^{38}$ years.
description: 51 pages, 9 figures, 7 tables, 1 appendix; v2 - added references in Section I, updated eqs. (18), (20), and (30) for clarity and consistency; v3 - addressed minor concerns from referee, reconsidered timeline for model testing, updated notation in eqs. (39) and (40) for consistency, addressed some formatting difficulties present in previous versions