title: ÐÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ Ð¸ Ð°ÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ Ð¼ÑÑÐµÐ¹ ÑÑÐ°Ð½ÑÐ³ÐµÐ½Ð½Ð¾Ð¹ Ð»Ð¸Ð½Ð¸Ð¸ SCA2-58Q
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Cognitive decline and mood alterations in the transgenic mice SCA2-58Q
Creators: name: ÐÐ°ÑÐ¸Ð½Ð¸Ð½Ð°, ÐÑÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÐ¿Ð¸Ð½Ð¾ÑÐµÑÐµÐ±ÐµÐ»Ð»ÑÑÐ½Ð°Ñ Ð°ÑÐ°ÐºÑÐ¸Ñ
Ð¼Ð¾Ð·Ð¶ÐµÑÐ¾Ðº
ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ
ÑÐ°ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð° Ð½Ð°ÑÑÑÐ¾ÐµÐ½Ð¸Ñ
ÑÑÐ°Ð½ÑÐ³ÐµÐ½Ð½ÑÐµ Ð¼ÑÑÐ¸
Ñ Ð»Ð¾ÑÐ·Ð¾ÐºÑÐ°Ð·Ð¾Ð½
ÑÐ¾Ð»Ð¸ÐµÐ²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ°
spinocerebellar ataxias
cerebellum
cognition
mood alterations
transgenic mice
chlorzoxazone
folic acid

description: Ð¡Ð¿Ð¸Ð½Ð¾ÑÐµÑÐµÐ±ÐµÐ»Ð»ÑÑÐ½Ð°Ñ Ð°ÑÐ°ÐºÑÐ¸Ñ Ð²ÑÐ¾ÑÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð° (Ð¡Ð¦Ð2) â ÑÑÐ¾ Ð°ÑÑÐ¾ÑÐ¾Ð¼Ð½Ð¾-Ð´Ð¾Ð¼Ð¸Ð½Ð°Ð½ÑÐ½Ð¾Ðµ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½Ð¾Ðµ Ð¿Ð¾Ð»Ð¸Ð³Ð»ÑÑÐ°Ð¼Ð¸Ð½Ð¾Ð²Ð¾Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ðµ. Ð¥Ð°ÑÐ°ÐºÑÐµÑÐ½ÑÐ¼Ð¸ ÑÐ¸Ð¼Ð¿ÑÐ¾Ð¼Ð°Ð¼Ð¸ Ð¡Ð¦Ð2 ÑÑÐ¸ÑÐ°ÑÑÑÑ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»ÑÐ½ÑÐµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ. Ð Ð¿Ð¾ÑÐ»ÐµÐ´Ð½Ð¸Ðµ Ð³Ð¾Ð´Ñ Ð²ÑÐµ ÑÐ°ÑÐµ Ð·Ð°ÑÐ²Ð»ÑÐµÑÑÑ Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¹ ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÑ ÑÑÐ½ÐºÑÐ¸Ð¹ Ð¸ ÑÐ°ÑÑÑÑÐ¾Ð¹ÑÑÐ² Ð½Ð°ÑÑÑÐ¾ÐµÐ½Ð¸Ñ, Ð²ÑÐ·Ð²Ð°Ð½Ð½ÑÑ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ Ð¿Ð¾Ð²ÑÐµÐ¶Ð´ÐµÐ½Ð¸ÑÐ¼Ð¸ Ð¼Ð¾Ð·Ð¶ÐµÑÐºÐ°, Ð² ÑÐ¾Ð¼ ÑÐ¸ÑÐ»Ðµ Ð¼Ð½Ð¾Ð³Ð¸Ð¼Ð¸ ÑÐ¸Ð¿Ð°Ð¼Ð¸ Ð¡Ð¦Ð, Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð². Ð ÑÐ²Ð¾ÐµÐ¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¼Ñ Ð¿ÑÐ¾Ð²ÐµÐ»Ð¸ ÑÑÐ´ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÐ¾Ð² Ð½Ð° Ð¼ÑÑÐ°Ñ ÑÑÐ°Ð½ÑÐ³ÐµÐ½Ð½Ð¾Ð¹ Ð»Ð¸Ð½Ð¸Ð¸ SCA2â58Q Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸ÐµÐ¹ ÑÐµÐ»Ð¾Ð²ÐµÑÐµÑÐºÐ¾Ð³Ð¾ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ Ð°ÑÐ°ÐºÑÐ¸Ð½Ð°-2 ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐ½Ð¾ Ð² ÐºÐ»ÐµÑÐºÐ°Ñ ÐÑÑÐºÐ¸Ð½ÑÐµ (ÐÐ) ÐºÐ¾ÑÑ Ð¼Ð¾Ð·Ð¶ÐµÑÐºÐ° Ð´Ð»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐ°ÑÑÐ¸Ñ ÐÐ Ð² Ð½Ðµ Ð¼Ð¾ÑÐ¾ÑÐ½ÑÑ ÑÐ¸Ð¼Ð¿ÑÐ¾Ð¼Ð°Ñ Ð¿ÑÐ¸ Ð¡Ð¦Ð2. Ð¢Ð°ÐºÐ¶Ðµ Ð¼ÑÂ  Ð¿ÑÐµÐ´Ð¿ÑÐ¸Ð½ÑÐ»Ð¸ Ð¿Ð¾Ð¿ÑÑÐºÑ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð¸ÑÑ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½ÑÐµÑÐºÐ¸Ðµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ Ñ Ð¡Ð¦Ð2 Ð¼ÑÑÐµÐ¹ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¼Ð¾Ð´ÑÐ»ÑÑÐ¾ÑÐ°Â  ÐºÐ°Ð»ÑÑÐ¸Ð¹-Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ ÐºÐ°Ð»Ð¸ÐµÐ²ÑÑ ÐºÐ°Ð½Ð°Ð»Ð¾Ð² Ð¼Ð°Ð»Ð¾Ð¹ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÐ¸ ÑÐ»Ð¾ÑÐ·Ð¾ÐºÑÐ°Ð·Ð¾Ð½Ð° Ð¸ ÑÐ¾Ð»Ð¸ÐµÐ²Ð¾Ð¹ ÐºÐ¸ÑÐ»Ð¾ÑÑ, Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑÐµÐ¹ Ð°Ð½ÑÐ¸Ð´ÐµÐ¿ÑÐµÑÑÐ¸Ð²Ð½ÑÐ¼ Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼.
description: Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant genetic neurodegenerative polyglutamine disorder. Distinctive symptoms of SCA2 are different motor abnormalities. Nowadays it has been increasingly reported about patients cognitive and mood disorders caused by various cerebellar damages, including many types of SCA. In our study, we use a series of behavioral tests with SCA2-58Q transgenic mice with Purkinje cell (PC)-specific expression of human mutant ataxin-2. We investigate the involvement of PC in non-motor symptoms of SCA2. We also try to recover electrophysiological and behavioral impairments of our mice by using a positive modulator of small conductance calcium-activated potassium channels chlorzoxazone and folic acid, which is known for its antidepressant properties.