cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
HGSOC subtypes and treatment interaction : implications for clinical implementation of the PrOTYPE classifier
Creators: name: Cairns, Evan Svensson
Publisher: name: University of British Columbia
Year: 2023

description: High-grade serous ovarian cancer (HGSOC) represents approximately 70% of cases of ovarian carcinoma. Investigation into its molecular features led to the discovery of four subtypes of HGSOC, which differ from each other in their gene expression, cellular composition and survival outcomes. However, methods of whole-genome expression clustering have limited the reproducibility of existing subtype-specific research findings as well as being unsuitable for use in individual cases, such as in a clinical setting. PrOTYPE has been developed as a clinical-grade tool for determining the subtype of HGSOC tumours according to expression of a select panel of genes. To investigate the potential utility of determining HGSOC subtype using PrOTYPE in the clinical decision-making process, this thesis has two aims: 1) explore subtype-specific differences in survival outcomes of HGSOC patients treated with the anti-angiogenic drug bevacizumab, to determine whether subtype could be used to inform treatment decisions, and 2) evaluate the subtypes of paired samples collected before and after treatment to platinum and taxane chemotherapy to determine whether exposure to chemotherapy induces changes in subtype. In Aim 1, I found that cases belonging to the immunoreactive C2.IMM subtype generally had improved overall and progression-free survival when treated with bevacizumab. Results also suggested that the C5.PRO subtype may be associated with poorer survival when treated with bevacizumab compared to if treated with platinum and taxane chemotherapy alone. However, these findings could not be validated in independent cohorts; stratification of patients by subtype-specific treatment response in a clinical setting would require further investigation before being implemented. Additionally, a search for novel genes associated with differential treatment outcomes with bevacizumab identified several genes that may be useful in future research on targeted approaches to bevacizumab treatment. In Aim 2, I found that change in subtype from before to after exposure to neoadjuvant chemotherapy occurred in the majority (11/16) of the cases studied; this indicates that pre-chemotherapy subtype cannot be determined from post-chemotherapy samples. Clinical and prognostic significance of HGSOC subtype after chemotherapy remains an area for future investigation. Subtyping using PrOTYPE could be used in the clinical context to guide treatment decisions and evaluate patient prognosis.
title: Association of Circle of Willis Variants and Carotid Plaque Morphology with Cerebral Infracts in Carotid Endarterectomy Subjects
Creators: name: Varga, Andrea
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Ischaemia / Infarction
subject: Arteriosclerosis
subject: Surgery
subject: MR-Diffusion/Perfusion
subject: MR
subject: CT-Angiography
subject: Vascular
subject: Neuroradiology brain
subject: Anatomy

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Blood flow reduction secondary to significant internal carotid artery (ICA) stenosis requires compensation to maintain adequate cerebral perfusion primarily through the circle of Willis (CoW). The prevalence of hypoplastic or non-visualized CoW...
MOESM3 of Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)
Creators: name: Dong, Di
name: Zhang, Fan
name: Zhong, Lian-Zhen
name: Fang, Meng-Jie
name: Huang, Cheng-Long
name: Yao, Ji-Jin
name: Sun, Ying
name: Tian, Jie
name: Ma, Jun
name: Tang, Ling-Long
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 3. Supplementary methods.
Star Formation in GMCs: A View from STARFORGE
Creators: name: Grudić, Mike
Publisher: name: Zenodo
Year: 2021

description: Star formation (SF) has historically been challenging to model realistically due to the wide range of physics to account for, including gravity, hydrodynamics, magnetic fields, dust, chemistry and cooling, radiation, and stellar feedback. I will present STARFORGE, the first numerical framework to simulate SF in GMCs to 1) account for all of these physics in concert, including all important feedback mechanisms (jets, radiation, winds, and supernovae), 2) predict an IMF from these physics self-consistently , and 3) simulate the entire gas mass of the massive (1e4+ solar mass) GMCs responsible for most star formation. After briefly reviewing some of the numerical techniques that make this possible, I will present the results of a representative STARFORGE simulation of a 2e4 solar mass GMC, run with our full physics package. The GMC converts 8% of its mass to stars before feedback destroys it after ~7Myr, halting SF and producing an unambiguous IMF sampled by more than 1500 stars. Th e IMF bears a strong resemblance to the observed one if and only if feedback is accounted for: jet feedback regulates low-mass star formation and the IMF turn-over, while massive stars' growth must be further regulated by their winds and radiation. Nearly all massive stars end up in binaries, while most low-mass stars are single, as observed. I will conclude by summarizing the successes of this new generation of simulation, while also pointing out some new open problems hinted at by STARFORGE's failures.
Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).
Creators: name: Ragone Concetta
name: Manolio Carmen
name: Cavalluzzo Beatrice
name: Mauriello Angela
name: Tornesello Maria Lina
name: Castiglione Filippo
name: Vitagliano Luigi
name: Iaccarino Emanuela
name: Ruvo Menotti
name: Maria, Tagliamonte
name: Buonaguro Luigi
Publisher: name: Zenodo
Year: 2021

description: Background The host’s immune system develops in equilibrium with both cellular self-antigens
 and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune system an additional pool of non-self-antigens, namely tumor antigens (tumor-associated antigens, TAAs; tumor-specific antigens, TSAs).
 Methods In the present study, we looked for homology between published TAAs and non-self-viral-derived epitopes. Bioinformatics analyses and ex vivo immunological validations have been performed.
 Results Surprisingly, several of such homologies have been found. Moreover, structural similarities between paired TAAs and viral peptides as well as comparable patterns of contact with HLA and T cell receptor (TCR) α and β chains have been observed. Therefore, the two classes of non-self-antigens (viral antigens and tumor antigens) may converge, eliciting cross-reacting CD8+T cell responses which possibly drive the fate of cancer development and progression.
 Conclusions An established antiviral T cell memory may turn out to be an anticancer T cell memory, able to control the growth of a cancer developed during the lifetime if the expressed TAA is similar to the viral epitope. This may ultimately represent a relevant selective advantage for patients with cancer and may lead to a novel preventive anticancer vaccine strategy.
Calculations of added mass for a cylindrical component submerged in a confined fluid
Creators: name: Ching-Ching Yu
name: Whittaker, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: 90504 Earthquake Engineering
subject: FOS: Civil engineering

description: Earthquake shaking of a submerged component induces hydrodynamic loadings on its surface generated by the adjacent liquid. If the amplitude of the seismic motion is small, the adjacent liquid is attached to and moves with the component. This attached liquid can be considered as added mass on the component. This document presents analytical solutions for added masses on rigid or flexible cylindrical components derived in a prior study and developed by the authors. Added masses for components with dimensions and mechanical properties applicable to liquid-filled advanced nuclear reactors are calculated. The differences in the calculated added masses with the assumption of rigid and flexible components are discussed. Ignoring flexibility of the submerged components leads to an overestimation of the added masses.
Direito e Justiça, n. Especial (2004)
Creators: name: Direito E Justiça
Publisher: name: Direito e Justiça
Year: 2004

description: Discurso de abertura da Excelentíssima Senhora Ministra da Justiça, Dra. Celeste Cardona...7-12 Degredo e colonização portuguesa: um círculo vicioso do colonialismo português em África...15-34 Pensar a história das prisões em Portugal: entre resultados e desafios...35-45 Atitudes populares e repressão policial da criminalidade em Lisboa (1880-1910)...47-67 A PIDE/DGS e as prisões políticas. 1945-1974...69-94 Anomia em Durkheim - entre a sociologia e a psicologia prisionais...95-117 A prisão e as suas novas redundâncias...119-125 Agressores sexuais em meio prisional: investigação, avaliação e intervenção...127-140 Bases de dados genéticos com fins forenses...141-146 Adaptação à vida prisional e mecanismos de coping...147-169 Os tempos e o tempo da reforma...171-184 Da «afirmação de direitos» à «protecção de direitos» dos reclusos: a jurisdicionalização da execução da pena de prisão...185-195 O sistema prisional na óptica dos Direitos Fundamentais dos Cidadãos...197-203 Intervenção jurisdicional na execução das reacções criminais privativas da liberdade - aspectos práticos...205-268 Reinserção social - perspectivas para o século XXI...269-283 As reformas do sistema de execução de penas e do sistema prisional e o papel do advogado. Finalmente a dignidade que se impõe?...285-299 O futuro dos estudos penitenciários...301-329 A minha experiência prisional...331-348
Project Summary: Seeing, Understanding, Believing: A Farmer-Led Project into Waterway Improvement
Creators: name: Benny, Tony
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management

description: This article summarises the results of a Rural Professionals Fund project that aimed to package practical methods for farmers to self-monitor waterway condition and ecological health and integrate the results with strategic farm and catchment planning. All text in this article is licensed for re-use under Creative Commons Attribution 4.0 International (CC BY 4.0).
Beyond 1 Million Genomes (B1MG) M3.5 The B1MG data analysis challenge results
Creators: name: Gut, Ivo
name: Aguileta Estrada, Gabriela
Publisher: name: Zenodo
Year: 2023
Subjects: Beyond 1 Million Genomes
B1MG
1+MG
1+Million Genomes Initiative

description: Beyond 1 Million Genomes (B1MG) M3.5 The B1MG data analysis challenge results
Direito e Justiça, v. 18 n. 2 (2004)
Creators: name: Direito E Justiça
Publisher: name: Direito e Justiça
Year: 2004

description: Inmigración/Xenofobia ante las instituciones culturales y religiosas...7-38 Reflexões sobre a génese do chamado "projecto" de Constituição de 1808, a outorgar, por Napoleão, a Portugal...39-186 O Tratado de Nice e a reforma do sistema jurisdicional comunitário...187-214 O conflito de deveres no exercício da medicina. Arguição da Dissertação de Mestrado "O Conflito de Deveres em Direito Penal Médico" do Licenciado Duarte Alberto Rodrigues Nunes...215-240 A nova lei da adopção...241-258 Environmental Tax: from the theory to the reality...259-296 Da natureza jurídica das Ordens Profissionais: associações públicas ou associações de empresas? - a propósito de dois acórdãos do Tribunal de Justiça das Comunidades Europeis...297-321 Breves notas em defesa da utilizção de trabalhos empíricos no estudo do Direito...323-326 Direitos do Homem. União Europeia e Justiça. Para um espaço e uma cultura de maior liberdade, segurança e responsabilidade...327-337 A Era do Controle. Introdução crítica ao direito penal cibernético...339-351
Direito e Justiça, v. 15 n. 2 (2001)
Creators: name: Direito E Justiça
Publisher: name: Direito e Justiça
Year: 2001

description: Editorial...5-6 Direito cibernético: a situação em Portugal...9-26 A propósito de uma recensão de Martim de Albuquerque...335-336 Imunidades constitucionais e crimes de responsabilidade...27-48 Fundamental rights in the European Union - Pleading for certainty in a fragile structure...49-57 Notas sobre o regime geral das infracções tributárias (Aprovado pela Lei n.º 15/2001, de 5 de Junho)...59-70 Reinventing public service between the autonomy of the market and the duty of public interest...71-84 Do estatuto jurídico da Universidade Católica Portuguesa...85-121 Direito penal e ética sexual...123-145 Os direitos sociais e a Carta dos Direitos Fundamentais da União Europeia...147-163 A despesa pública e a política do ambiente. Algumas considerações...165-187 A Carta dos Direitos Fundamentais da União Europeia e os direitos sociais...189-230 O crime de distribuição ilícita de bens da sociedade...231-331
The Role of (De-)Centralized Wage Setting for Industry Dynamics and Economic Growth. An Agent-Based Analysis with the Eurace@Unibi Model
Creators: name: Dawid, Herbert
name: Harting, Philipp
name: Neugart, Michael
Publisher: name: Bielefeld University, Department of Business Administration and Economics
Year: 2019
Subjects: subject: 330
subject: centralized wage bargaining
subject: collective agreement
subject: de-unionization
subject: industry dynamics
subject: inequality
subject: growth
subject: etace_WP

description: In this paper, we employ the agent-based macroeconomic Eurace@Unibi model to study the economic implications of different degrees of de-centralization in the wage setting. Starting from a baseline scenario, corresponding to a high degree of unionization, in which wages are fully centralized and indexed on economy-wide productivity gains and inflation, we investigate how an increasing level of de-centralization affects the dynamics of output, employment, inequality, and market concentration. We think of decentralization as wages being a weighted average of an economy-wide `union wage' and a firm-specific component depending on the firm's productivity and the experienced tightness of the labor market. Our findings suggest that stronger centralization of the wage setting process induces lower wage inequality and stronger concentration on the consumption good market. Furthermore, due to more physical investments, an economy with more centralized wage set- ting is characterized by higher productivity and faster economic growth.
Fuel treatment efficacy in fire-prone forests of interior British Columbia, Canada
Creators: name: Rutherford, Kea
Publisher: name: University of British Columbia
Year: 2023

description: Extreme wildfire seasons have become a central challenge of forest management in western North America. In response to increasing wildfire risk, forest managers are proactively implementing fuel treatments. Although impacts of fuel treatments have been studied in the western United States, comparable research in the fire-prone forests of western Canada is lacking. In this thesis, I used two approaches to assess the efficacy of alternative fuel treatments to mitigate fire behaviour and effects in the seasonally dry forests of southeastern British Columbia, Canada. I partnered with five community forests in the Kootenay region and measured key components of the wildland fuelbed in forest stands before and after treatment. For the first approach, I used the pre-treatment field data as a baseline and simulated 16 alternative fuel treatment scenarios that spanned the range of thinning, pruning, and surface fuel load reduction combinations being implemented in the region. I modelled stand-level fire behavior (i.e., passive and active crown fire) and effects (i.e., tree mortality) under these simulated stand conditions using Fuels Management Analyst Plus (FMA), and fitted meta-models to assess the treatment impacts. For the second approach, I categorized the fuel treatments implemented by the community forests into five different types based on thinning, pruning, and residue fuel management. I examined the variability of key stand attributes within fuel treatment types. Then, I determined the impacts of the five treatment types on fire behaviour and effects metrics obtained from FMA. Based on results from both approaches, removal of small trees reduced risk of passive crown fire, but concurrent removal of larger trees was necessary to reduce risk of active crown fire. Pruning had minimal impact on mitigating potential of passive crown fire. Ameliorating residue fuels through chipping or pile burning reduced risk of passive crown fire; however, the impacts of chipping on residual tree mortality remains a potential concern. This work provides the first insights into the efficacy of fuel treatments in the Kootenay region and will help forest managers make more informed wildfire management decisions.
Direito e Justiça, v. 15 n. 1 (2001)
Creators: name: Direito E Justiça
Publisher: name: Direito e Justiça
Year: 2001

description: «A dignidade da pessoa humana, fundamento da justiça». Homilia na Missa da abertura do Ano Judicial Sé Patriacal, 8 de Fevereiro de 2001...5-7 O Tribunal Penal Internacional e a prisão perpétua - que futuro?...11-20 A crise da justiça. Três recados aos Magistrados e Advogados do século que começa...21-29 La protection juridictionnelle des droits de l'homme en Europe: juges nationaux et juges européens. Conclusions generales...31-44 Responsabilidade civil das concessionárias das auto-estradas...45-100 Sobre os crimes de fraude fiscal e burla...101-157 Os dados punitivos e a função punitiva da responsabilidade civil...159-206 A publicidade da matéria de facto...207-227 O direito de intervenção...231-240 Nações Unidas - desafios e perspectivas da intervenção humanitária...241-256 Intervenções militares: necessidade política, de segurança e humanitária...257-265 Desafios globais...267-272
MOESM4 of Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)
Creators: name: Dong, Di
name: Zhang, Fan
name: Zhong, Lian-Zhen
name: Fang, Meng-Jie
name: Huang, Cheng-Long
name: Yao, Ji-Jin
name: Sun, Ying
name: Tian, Jie
name: Ma, Jun
name: Tang, Ling-Long
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 4. ICTOS calculation formula.
MPEC 2023-X242 : DAILY ORBIT UPDATE (2023 December 12)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
DEPRECATED
Creators: name: DEPRECATED
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Harpegnathos
Harpegnathos saltator
Harpegnathos saltator cruentatus (smith, 1858)
Iridomyrmex
Iridomyrmex purpureus
Lasius
Lasius alienus
Lasius emarginatus
Lasius flavus
Lasius umbratus
Leptogenys
Leptogenys processionalis
Liometopum
Liometopum microcephalum
Manica
Manica rubida
Messor
Messor arenarius
Messor barbarus

description: DEPRECATED
Three essays on environmental and development economics
Creators: name: Madhok, Raahil
Publisher: name: University of British Columbia
Year: 2023

description: This dissertation presents three essays on Environmental and Development Economics. The first studies how economic activity erodes biodiversity and the role of decentralized institutions for achieving sustainable development. The second explores how structural change affects the geography of agriculture. The third focuses on legacies of coal power plant investments. This blend of short-term, spatial, and long-term analyses produces a comprehensive body of work that helps deepen our understanding of how economic activity shapes the environment. Chapter 2 documents biodiversity loss triggered by infrastructure expansion in India. Combining new data on infrastructure-driven deforestation with one million birdwatching diaries, and exploiting within-birdwatcher travel for identification, I find that infrastructure development drives 20% of total species loss and that species diversity does not recover in the medium run. Fortunately, species loss is more than halved when local institutions empower marginalized communities who are excluded from project planning. Informed consent by tribes is a key mechanism, underscoring the importance of grassroots institutions for balancing development and conservation. Chapter 3 studies the land use implications of internal migration in India. Using household microdata and a shift-share instrument for migration, we document sharp declines in crop production among migrant-sending households. Guided by a spatial equilibrium model, we find that non-migrant households living in the same village, as well as in more remote villages, contrastingly expand farming and adopt technology. Over half of aggregate production losses are cushioned by these spillovers, leading to a spatial reallocation of food production from urban to remote areas. Chapter 4 quantifies the long-run health effects of India’s coal power plants. Using an atmospheric dispersion model to compute an exogenous measure of cumulative exposure to power plant pollution, we find that a one standard deviation increase in this measure increases child mortality by 1.3 per 1,000 births. These effects are largely driven by exposure in utero, as well as exposure to private power plants built between 1992-2005. We find no evidence of differential economic development between more and less exposed districts, underscoring pollution as the main mechanism.
Sustainability and Justice: Challenges and Opportunities for an Open STEM Education
Creators: name: Eaton, Carrie
name: Bonner, Kaitlin
name: Cangialosi, Karen
name: Dewsbury, Bryan
name: Diamond-Stanic, Maggie
name: Douma, Jason
name: Smith, Michelle
name: Wojdak, Jeremy
name: Taylor, Robin
Publisher: name: QUBES Educational Resources
Year: 2022

description: Combining understanding of OER sustainability and equity and justice to carve out ideas for the future of STEM open education.
MOESM7 of MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
Creators: name: Mao, Yuan
name: Fan, Weifei
name: Hu, Hao
name: Zhang, Louqian
name: Michel, Jerod
name: Wu, Yaqin
name: Wang, Jun
name: Jia, Lizhou
name: Tang, Xiaojun
name: Xu, Li
name: Chen, Yan
name: Zhu, Jin
name: Feng, Zhenqing
name: Xu, Lin
name: Yin, Rong
name: Tang, Qi
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 7: Table S2. Primer and siRNA sequences.
Numerical methods for biological flows laden with deformable capsules and solid particles
Creators: name: Huet, Damien P.
Publisher: name: University of British Columbia
Year: 2023

description: Biological fluids such as blood accomplish many vital tasks in the human body, including carrying oxygen and nutrients to tissues, regulating internal temperature and pH, or transporting white blood cells to infected areas. A better understanding of these fluids can provide insight into many pathologies such as the formation of aneurysms and the effect of sickle cell disease on the flow of red blood cells, as well as help design efficient diagnosis tools on microfluidic devices. Such fluids are composed of a continuous viscous phase and suspended bodies, including rigid particles and deformable membranes enclosing an inner fluid, referred to as capsules. In this thesis, we develop numerical tools aiming to simulate cell-resolved biological fluids such as blood. In a first part, we focus on the dispersed solid phase, a field known as granular mechanics. In this context, we implement a contact force able to accurately model static assemblies of granular media. After extensive validation, we use this contact model in a purely granular setting to study avalanches of entangled particles. Our numerical results are compared to experiments and show very good qualitative and quantitative agreement. Moreover, we present a variety of novel avalanching behaviors, as well as an intermittent regime in which reproducibility is lost. After analyzing the microstructure of granular assemblies in this regime, we conclude that it likely arises from mesoscale clusters of particles. In a second part, we concentrate on flowing biological capsules. We develop an adaptive front-tracking method which enables simulations of capsules in very large geometries for a wide range of Reynolds number. We validate our solver extensively and we show excellent qualitative and quantitative agreement with the literature. We then study the dynamics of capsules flowing through a sharp corner, a commonly encountered geometry in microfluidic devices. We analyze the trajectory, normalized velocity and area variations of the capsules and we show that in our case of strong confinement, the capsules interact weakly unless they are located very close to each other. Finally, we present and implement a fully Eulerian alternative method to simulate flowing capsules, and we highlight its advantages and limits.
ANIMA D2.6 – Overview of the use of noise footprints for different operational, planning and communication purposes
Creators: name: Hooper, Paul
name: Müller, Uwe
name: Van Oosten, Nico
name: Dimitriu, Delia
Publisher: name: Zenodo
Year: 2019
Subjects: aviation noise
noise footprint
ICAO Balanced Approach
Community noise

description: This ANIMA Deliverable sets out to review available noise metrics and tools to help identify effective and ineffective practice with the aim of informing the development of a Best Practice portal designed to assist airports to make the best use of noise modelling tools and their outputs.

The review acknowledges the growth in the range of noise indicators now in use, often developed in an attempt to address specific stakeholder requirements. Whilst on the one hand the enhanced capability to ‘capture’ different aspects of the noise environment, on the other the picture can be seen as overly complex and confusing.

In an attempt to provide some structure to the noise information now available and the modelling tools used to arrive at many of these outputs Sections 3 and 4 of this Deliverable develop frameworks for their categorisation.

The Deliverable concludes that it is impossible to define best practice noise metrics on the basis of evidence from systematic assessments. Thus, given the absence of the latter it is only possible to define the principles of best practice in the selection and use of noise information. These are that when establishing how best to communicate noise, airports and others with authority over noise management should engage with stakeholders throughout the process of Balanced Approach interventions. This should facilitate focused use of noise information that:
Supplementary material
Creators: name: Časaitė, Vida
Publisher: name: Zenodo
Year: 2021

description: Figure S1: SDS PAGE analysis of protein 041 synthesis in E. coli BL21 (DE3) cells. Table S1: Primers used for cloning of truncated 041 gene variants. Figure S2: TEM analysis of nanotubes of recombinant protein 041 and its truncated variants. Figure S3: Thermostability of 041Δ200YqfB and YqfB after 2 and 24 h of incubation.
Using Cause and Effect Relationships to Enhance Freshwater Management
Creators: name: Fitchman, Jackie
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 410404
subject: Environmental management

description: We've summarised research on how Aotearoa's fresh water responds to stressors into a short Research Findings Brief. Using Lake Hayes near Queenstown as a scenario example, the research brief describes how this research can be used to prioritise actions to take on land to prevent and reverse degradation. This research can help us manage and restore fresh water, and encourages deeper understanding of complex ecosystems.

Research Findings Brief
GTTM分析器「PyGTTM」の試作,及び, ディープラーニングを用いた精度向上の試み
Creators: name: 山川峻
Publisher: name: Zenodo
Year: 2022
Subjects: GTTM
Melody Analysis
ATTA
Deep Learning
Melody Structure
Timespan

description: 人間が楽曲のジャンルや年代の推定を行うとき,使われている楽器などからだけ でなく,楽曲内の構造を無意識に感じとり,行っているのではないかという仮説か ら,楽曲中には構造的に何らかの特徴があり,それを抽出することができれば,よ り精緻な楽曲分析が行えるだろう.楽曲から構造を取り出す手法として,GTTM が挙げられる.音楽の認知過程から階層的な構造の分析を目的とした理論である. 本研究は,音楽を階層的な構造で表すことができる GTTM を利用して,楽曲の 構造を自動で取り出すシステムの開発を目指している.既に浜中らによって自動 GTTM 分析器の ATTA が公開されているが,コードを確認しながらの構造分析が できないといったことから,ATTA に基づいた GTTM 分析器「PyGTTM」の試 作を行った. ATTA との比較実験では,GTTM データベースに収められてる楽曲データを用 いて,グルーピング構造,拍節構造,タイムスパン木の三つの出力結果の比較を 行った.グルーピング構造分析では ATTA よりも高い精度を示したが,拍節構造分 析とタイムスパン分析では低い値となった.これは,PyGTTM と ATTA で GTTM の曖昧な部分をどう解釈したかによる,処理のコーディングの違いが原因だと考 えられる.しかしながら,ATTA と結果に差異はあったが,ある程度の精度で階 層構造を獲得できることを確認した.また,PyGTTM のタイムスパン木には精度 に問題があったため,deepGTTM を参考にして,ディープラーニングを用いて精 度の向上させる機能の拡張の検討を行っている.
MOESM8 of MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
Creators: name: Mao, Yuan
name: Fan, Weifei
name: Hu, Hao
name: Zhang, Louqian
name: Michel, Jerod
name: Wu, Yaqin
name: Wang, Jun
name: Jia, Lizhou
name: Tang, Xiaojun
name: Xu, Li
name: Chen, Yan
name: Zhu, Jin
name: Feng, Zhenqing
name: Xu, Lin
name: Yin, Rong
name: Tang, Qi
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 8: Table S3. MAGE-A1-scFv amino acid sequence.
Regenerative agriculture - opening up the wallet
Creators: name: Dickey, Delwyn
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management

description: Regenerative agriculture has potential as a selling point for our export markets, but how do the numbers stack up for farmers?
This article summarises the results of a Rural Professionals Fund project that aimed to help people understand the financial implications of adopting regenerative farming practices.
All text in this article is licensed for re-use under Creative Commons Attribution 4.0 International (CC BY 4.0). First published in New Ground magazine (Vol. 2), December 2022
MPEC 2023-J136 : 2023 JY1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JY1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Experiential Discipline: Informing and Reforming Discipline in Secondary Schools in Alberta
Creators: McCauley, Caitlin
Publisher: name: University of Alberta Library
Year: 2025

Effective school discipline is a complex and evolving issue in modern education. As classroom dynamics, school cultures, and student populations change, disciplinary practices must also change in order to remain effective. John Dewey’s philosophy of education as both experiential and social provides a theoretical framework for future disciplinary policies that are responsive, rather than reactive. Using Deweyan theories and evaluating the history of discipline in the North American school context, this qualitative study will identify issues within modern discipline policies and suggest a path forward using experiential learning as a model of effective school discipline.
Da natureza jurídica das Ordens Profissionais: associações públicas ou associações de empresas? - a propósito de dois acórdãos do Tribunal de Justiça das Comunidades Europeis
Creators: name: Campos, Manuel Fontaine
Publisher: name: Direito e Justiça
Year: 2004

description: Direito e Justiça, v. 18 n. 2 (2004)
MPEC 2023-J137 : 2023 JZ1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JZ1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 5 of Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development
Creators: name: Du, Zeyu
name: Zhang, Duo
name: Li, Jun
name: Li, Qingwei
name: Pang, Yue
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 4. Fig. S4: DHA targeted tfr induces ferroptosis. (A) Representative phenotypes of zebrafish after DHA treatment. (B) Inhibition of DHA on the transcription of zebrafish tfr1a. (C) Inhibition of DHA on the transcription of zebrafish lip. (D) Survival rate of zebrafish after DHA treatment. (E) Phenotypic classification of zebrafish after DHA treatment. Data were given as means ± standard deviation. All figures are representative of three biological replicates (per test n=10). ***, P<0.001; **, P<0.01; *, 0.01
Surrogate assisted reliability analysis and probabilistic design of structures under uncertainty
Creators: name: Das, Sourav
Publisher: name: University of British Columbia
Year: 2023

description: This thesis presents the reliability analysis and probabilistic design of a one-storey moment-resisting frame coupled with a nonlinear energy sink (NES) with negative stiffness and sliding friction and a shape memory alloy (SMA)-based damped outrigger structure when the structures are subjected to earthquake excitation. Initially, the reliability-based design optimization (RBDO) of the above structures is carried out to estimate the tuning parameters of NES and SMA so that the proposed systems produce effective performances when exposed to uncertain environments. To do that, the probability of failure of the structure is estimated using an outcrossing rate approach based on a stationary assumption. To reduce the computational time, a surrogate model is used in the RBDO analysis. To overcome stationary assumption, the next work is devoted to formulate an efficient reliability analysis method using surrogate model-based probability density evolution method (PDEM). The PDEM is used to estimate the probability density function (PDF) of the structural responses. The partial differential equations (PDE) in PDEM are solved using the finite difference method coupled with total variation diminishing, in which a set of representative points of random parameters are generated using the generalized F-discrepancy scheme. To obtain satisfactory accuracy of the numerical solution, representative points are needed, which becomes computationally expensive for complex structures. To reduce the computation burden, the stochastic spectral embedding (SSE) surrogate model is used, which approximates the original response surface. The SSE is a class of supervised machine learning algorithm where it is trained by few observations and enables output prediction as spectral representation. In general, PDE in PDEM are solved using a finite difference scheme in which the accuracy of the numerical solution depends on the number of temporal and spatial discretizations, making them computationally inefficient for high-fidelity models. With this in view, the last work is devoted to forming a physics-informed neural network (PINN) based PDEM, for solving the PDE. This method does not need any interpolation or coordinate transformation, which is often seen in any numerical scheme, thus the computational budget is reduced. Lastly, time-dependent reliability analysis of the above structures is performed using the proposed PINN-based PDEM.
O conflito de deveres no exercício da medicina. Arguição da Dissertação de Mestrado "O Conflito de Deveres em Direito Penal Médico" do Licenciado Duarte Alberto Rodrigues Nunes
Creators: name: Nunes, Duarte Alberto Rodrigues
Publisher: name: Direito e Justiça
Year: 2004

description: Direito e Justiça, v. 18 n. 2 (2004)
Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy.
Creators: name: Cavalluzzo Beatrice
name: Ragone Concetta
name: Mauriello Angela
name: Petrizzo Annacarmen
name: Manolio Carmen
name: Caporale Andrea
name: Vitagliano Luigi
name: Ruvo Menotti
name: Buonaguro Luigi
name: Maria, Tagliamonte
Publisher: name: Zenodo
Year: 2021

description: The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in
 order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions
 in the residue at position 4 (p4) binding to TCR. The effect of such modifications also on the affinity to the
 major histocompatibility class I (MHC-I) molecule was assessed. The Trp2 antigen, specific for the mouse melanoma
 B16F10 cells, as well as the HPV-E7 antigen, specific for the TC1 tumor cell lines, were used as models. Affinity of such
 heteroclitic peptides to HLA was predicted by bioinformatics tools and the most promising ones were validated by
 structural conformational and HLA binding analyses. Overall, we demonstrated that TAAs modified at the TCR-binding
 p4 residue are predicted to have higher affinity to MHC-I molecules. Experimental evaluation confirms the stronger
 binding, suggesting that this strategy may be very effective for designing new vaccines with improved antigenic
 efficacy.
Reflexões sobre a génese do chamado "projecto" de Constituição de 1808, a outorgar, por Napoleão, a Portugal
Creators: name: Gomes Da Silva, Nuno J. Espinosa
Publisher: name: Direito e Justiça
Year: 2004

description: Direito e Justiça, v. 18 n. 2 (2004)
Setting up standard test cases for each studied process
Creators: name: Ambrosio, Danilo
name: Yadav, Pinku
name: Zouabi, Haythem
Publisher: name: Zenodo
Year: 2019

description: The objective of the Deliverable D3.1 is to set up all the standard test cases for each studied process. It aims to make an analysis of what have been done until now on these three processes’ studies.

The ESR 7, 8 and 9 have contributed in these analyses respectively on the three different subjects: Machining and Friction – Friction Stir Welding -Additive Manufacturing.

This report will be the basis for future experimental benches and tests.
MPEC 2023-J138 : 2023 JA2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JA2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 7 of Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development
Creators: name: Du, Zeyu
name: Zhang, Duo
name: Li, Jun
name: Li, Qingwei
name: Pang, Yue
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 6. Table S2: Germline transmission and frequency of lip gene
GBL and Creativity in Classes
Creators: name: Anisoara, Dumitrache; Bogdan, Logofatu; Beatrice, Almasan
Publisher: name: Editura Universitara
Year: 2012
Subjects: subject: 0 Social sciences
subject: 37 Education
subject: 371 Instructional design
subject: 004:37 Elearning

description: The aim of this paper is to present the results obtained during ProActive project, a European project having as main objective the creation of learning contexts in which educators (teachers, professors, trainers) of different LLP sub-programmes (Comenius, Leonardo da Vinci and Erasmus) can an apply their creativity in designing their own GBL scenarios using digital tools (two games editors: Eutopia and e-Adventure).
MPEC 2023-J139 : 2023 JB2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JB2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Leveraging novel process analytical technologies to access chiral small molecule drug precursors via dynamic crystallization
Creators: name: Kukor, Andrew
Publisher: name: University of British Columbia
Year: 2023

description: Dynamic crystallizations can drive the formation of enantiopure solid phases but require significant process understanding to achieve the necessary levels of control. Phase-specific data that sheds light on the solution and solid phases of crystallizations can facilitate this understanding and enable the development of such dynamic crystallizations. Building off previous work in the Hein Lab, this Thesis explores the development of two new phase-specific analytical tools for monitoring crystallizations and their application to dynamic crystallization development. A filter modification for Mettler-Toledo’s EasySampler probe is presented. This filter is capable of selectively sampling the solution phase of crystallizations, and its efficacy is demonstrated in a variety of crystallization tests. A complementary solid phase tool is developed using a webcam to monitor the turbidity of solutions, providing a solid phase monitoring tool and allowing automated solubility and nucleation measurements to be performed. These two tools were used in combination to investigate, optimize, and demonstrate the dynamic crystallizations of two unique small molecule drug precursors, each of which is currently isolated via crystallization. The first molecule was discovered to form an undesired racemic solid phase. As such, a multi-well continuous crystallization setup with dissolution, crystallization and inline racemization was used to kinetically control its dynamic crystallization. Based on this success, the crystallization of a second molecule was investigated in partnership with Genentech. Mechanistic understanding was achieved using our novel process analytical technology tools and traditional offline sampling, allowing a similar inline racemization approach to that used with the first molecule to be applied and optimized for the second molecule’s crystallization.
MOESM1 of The landscape of cardiovascular care in pediatric cancer patients and survivors: a survey by the ACC Pediatric Cardio-Oncology Work Group
Creators: name: Ryan, Thomas
name: Border, William
name: Baker-Smith, Carissa
name: Barac, Ana
name: Bock, Matthew
name: Canobbio, Mary
name: Choueiter, Nadine
name: Chowdhury, Devyani
name: Gambetta, Katheryn
name: Glickstein, Julie
name: Kondapalli, Lavanya
name: Mital, Seema
name: Peiris, Vasum
name: Schiff, Russell
name: Spicer, Robert
name: Towbin, Jeffrey
name: Chen, Ming
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Questions for Pediatric Cardio-Oncology Practice Survey.
4xCO2 and CTRL simulations for CESM2-FV2 with COSP - archive
Creators: name: Fouilloux, Anne
Publisher: name: Zenodo
Year: 2021

description: Jupyter notebook to visualize output from CESM2-FV2 runs. A 250 year control and a 150 4xCO2 run (starting 100 years into the control) with COSP enabled.Science publicationPublished : Citation: Bjordal, J., Storelvmo, T., Alterskjær, K. et al. Equilibrium climate sensitivity above 5 °C plausible due to state-dependent cloud feedback. Nat. Geosci. 13, 718–721 (2020). https://doi.org/10.1038/s41561-020-00649-1 (primary)
description: Research Object in rohub2020: https://w3id.org/ro-id/b5c39d3e-9398-4108-b474-cef8e3fb4c6d
Common Functional User Requirements for Electronic Registries Supporting the Provision of Contraceptive Methods
Creators: name: Inau, Esther
Publisher: name: figshare
Year: 2021
Subjects: subject: 80702 Health Informatics
subject: FOS: Media and communications

description: Standardized electronic registries are increasingly becoming an entry point to adopting client health records and facilitating population-level tracking of health services. They offer diverse functionalities including vital events tracking, electronic health records, electronic decision support, provide work planning and scheduling. However, electronic registries can only be appropriately designed by first getting a comprehensive picture of the actual tasks and processes associated with service provision; the issues and barriers experienced; and the content and flow of data - all within the local context and aligned with the local infrastructure. In this work a core group of experienced frontline health workers employed at the World Health Organization Headquarters was invited to collaboratively map and analyze the common workflows of healthcare workers involved in contraceptive care. The core group then collaboratively identified common functional user requirements that facilitate the development of electronic registries that support contraceptive care. The output from this work shows that involving frontline healthcare workers in requirements engineering for development of electronic registries is indeed a practical approach and a vital first step in ensuring their acceptability among users and applicability to clinical domains. The requirements gathered can be customized and used as guidance for software professionals developing electronic registries for use in various healthcare settings and contexts worldwide.