cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Double ratio of charmonia in p+Pb collisions at sqrt(s_NN)=5.02 TeV
Creators: name: Liu, Yunpeng
name: Ko, Che Ming
name: Song, Taesoo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Based on a kinetic description of J/psi dissociation and production in an expanding quark-gluon plasma that is described by a 2+1 dimensional ideal hydrodynamics, we have studied the double ratio R_{p Pb}(psi')/R_{p Pb}(J/psi) of charmonia in p+Pb collisions at sqrt(s_NN)=5.02 TeV by including not only the cold nuclear matter effects but also the hot nuclear matter effects. We find that the double ratio of prompt charmonia is significantly suppressed in the most central collisions as a result of the hot nuclear matter effects.
description: 4 pages, 3 figures, proceeding for the 30th Winter Workshop on Nuclear Dynamics
Dynamics of heterogeneous clusters under intense laser fields
Creators: name: Di Cintio, Pierfrancesco
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: We study the dynamics of atomic and molecular nano-clusters exposed to short and intense X-fel pulses
description: PhD Thesis, 133 pages, 60 (low quality) figures
Dense definiteness and boundedness of composition operators in $L^2$-spaces via inductive limits
Creators: name: Budzynski, Piotr
name: Planeta, Artur
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 47B33, 47B37, secondary 47A05, 28C20

description: The questions of dense definiteness and boundedness of composition operators in $L^2$-spaces are studied by means of inductive limits of operators. Methods based on projective systems of measure spaces and inductive limits of $L^2$-spaces are developed. Illustrative examples are presented.
Additional file 2 of Relationship between body composition indices and changes in body temperature due to hot pack use
Creators: name: Kominami, Kazuyuki
name: Sato, Kazunari
name: Takahashi, Naoaki
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Marine Biology
subject: Cancer
subject: Cardiology

description: Additional file 2. Correlations between the body composition indices of each body segment and changes in body temperature.
Antigenicity and Immunogenicity of Transmitted/Founder, Consensus, and Chronic Envelope Glycoproteins of Human Immunodeficiency Virus Type 1
Creators: name: Chen, H.
name: Montefiori, D. C.
name: Alam, S. M.
name: Scearce, R. M.
name: Haynes, B. F.
name: Swanstrom, R.
name: Foulger, A.
name: Xia, S.-M.
name: Lu, X.
name: Blinn, J. H.
name: Shaw, G. M.
name: Gao, F.
name: Liao, H.-X.
name: Korber, B.
name: Lapedes, A.
name: Sutherland, L. L.
name: Ma, B.-J.
name: Muldoon, M.
name: Bowman, C.
name: Hahn, B. H.
name: Watson, S.
name: Vandergrift, N.
name: Parks, R.
name: Tsao, C.-Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Human immunodeficiency virus type 1 (HIV-1) vaccine development requires selection of appropriate envelope (Env) immunogens. Twenty HIV-1 Env glycoproteins were examined for their ability to bind human anti-HIV-1 monoclonal antibodies (MAbs) and then used as immunogens in guinea pigs to identify promising immunogens. These included five Envs derived from chronically infected individuals, each representing one of five common clades and eight consensus Envs based on these five clades, as well as the consensus of the entire HIV-1 M group, and seven transmitted/founder (T/F) Envs from clades B and C. Sera from immunized guinea pigs were tested for neutralizing activity using 36 HIV-1 Env-pseudotyped viruses. All Envs bound to CD4 binding site, membrane-proximal, and V1/V2 MAbs with similar apparent affinities, although the T/F Envs bound with higher affinity to the MAb 17b, a CCR5 coreceptor binding site antibody. However, the various Envs differed in their ability to induce neutralizing antibodies. Consensus Envs elicited the most potent responses, but neutralized only a subset of viruses, including mostly easy-to-neutralize tier 1 and some more-difficult-to-neutralize tier 2 viruses. T/F Envs elicited fewer potent neutralizing antibodies but exhibited greater breadth than chronic or consensus Envs. Finally, chronic Envs elicited the lowest level and most limited breadth of neutralizing antibodies overall. Thus, each group of Env immunogens elicited a different antibody response profile. The complementary benefits of consensus and T/F Env immunogens raise the possibility that vaccines utilizing a combination of consensus and T/F Envs may be able to induce neutralizing responses with greater breadth and potency than single Env immunogens.
Statistical tests of sterile neutrinos using cosmology and short-baseline data
Creators: name: Bergström, Johannes
name: Gonzalez-Garcia, M. C.
name: Niro, V.
name: Salvado, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this paper we revisit the question of the information which cosmology provides on the scenarios with sterile neutrinos invoked to describe the SBL anomalies using Bayesian statistical tests. We perform an analysis of the cosmological data in $Λ$CDM$+r+ν_s$ cosmologies for different cosmological data combinations, and obtain the marginalized cosmological likelihood in terms of the two relevant parameters, the sterile neutrino mass $m_s$ and its contribution to the energy density of the early Universe $N_{\rm eff}$. We then present an analysis to quantify at which level a model with one sterile neutrino is (dis)favoured with respect to a model with only three active neutrinos, using results from both short-baseline experiments and cosmology. We study the dependence of the results on the cosmological data considered, in particular on the inclusion of the recent BICEP2 results and the SZ cluster data from the Planck mission. We find that only when the cluster data is included the model with one extra sterile neutrino can become more favoured that the model with only the three active ones provided the sterile neutrino contribution to radiation density is suppressed with respect to the fully thermalized scenario. We have also quantified the level of (in)compatibility between the sterile neutrino masses implied by the cosmological and SBL results.
description: 23 pages, 4 figures
title: Sub-lethal effects at stake: Does the acaricide Coumaphos and fungicide Folpet affect the hypopharyngeal glands size?
Creators: name: Risse, Marion
name: Dainat, Benjamin
name: Jeker, Lukas
Publisher: name: Julius Kühn-Institut
Year: 2018

description: Background: Pesticides are increasingly suspected to be involved at a global scale in honey bee decline. Most studies focuses on acute effects on mortality, whereas sub-lethal effects are poorly understood. Hypophryngeal glands (HPG), producing royal jelly to feed brood, are established marker to assess sub-lethal effects of pesticides where for example the size of the acini can be measured. The size of the later depends of different natural factors: the age of the bee and the type of task performed by the bee. The HPG are the best developed at the age of 10 days by nursing bees. Regarding the data requirements of the new EFSA bee guidance document and the recently developed OECD larva test 237 and 239 a data GAP regarding residues of PSM in the produced Royal Jelly by pesticide exposed bees which might have an adverse impact on larva development from day 1 to day 3 is recognized.
Method: The effects on the commonly and widely used varroacide coumaphos in hives and the fungicide folpet in agriculture are currently unknown. Here we measured the size of the acini of new emerged bees treated with field realistic and non-realistic doses of both substances dissolved in pollen patties fed ad libitum for nine days (N=3 cages with 20 bees in each group) and in small encaged colonies without queens. An untreated and acetone control were established. The effects of the pesticides on workers and residues in gelee royal were tested with and without brood to take into consideration variations according to the tasks performed by the bees due to labor division. . After staining HPG activity was measured as a proxy via acini size. The results will be discussed.
Results: Our results may help to improve knowledge in the development and validation of methods to evaluate the risk of bees exposed to pesticides for plant protection product authorization in an appropriate and comparable way which could be consequently implemented in standardized ring-test.
description: Julius-Kühn-Archiv, Nr. 462 (2018): Hazards of pesticides to bees 13th International Symposium of the ICP-PR Bee Protection Group 18. - 20. October 2017, València (Spain) - Proceedings -
PSDI Webinar: Pathfinder 2 Process Recording - Slides
Creators: name: Kanza, Samantha
Publisher: name: Zenodo
Year: 2023

description: In the Physical Sciences Data Infrastructure (PSDI) Our first round pathfinders are exploratory pieces of work looking at an application area where PSDI could develop tools to enhance the research infrastructure. This slide deck is from the Pathfinder 2: Process Recording webinar presented by Dr. Samantha Kanza which was run on 27th July 2023. https://www.psdi.ac.uk/event/webinar-psdi-pf2/ Abstract: Process recording is fundamental to ensuring the preservation of the scientific record and enabling reproducibility. The Electronic Lab Notebook (ELN) was originally created to serve as a direct replacement for the paper lab notebook, to ensure the digital capture and retention of the scientific record. What seemed like an obvious simple software-based solution has been anything but, and there are now over 80 active ELNs on the market and a wide range of different approaches have been taken to digitizing scientific research across academia and industry. This talk will discuss the shift in software offerings and attitudes to process recording software and report on the results of a recent survey on ELN and Notebook Usage in our physical sciences community. We will also discuss the current work that is being undertaken in this pathfinder to produce a comprehensive resource on process recording tools to aid researchers in identifying the best solution(s) for them. It will also cover research being undertaken around the different aspects of process recording, and community recommendations for making improvements in these areas, such as metadata, semantics, data standards and the use of hybrid/voice technologies. The recording of this webinar can be found on YouTube: https://youtu.be/r2Hre41xJSk
Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release
Creators: name: Harvey, S. C.
name: Bower, B. D.
name: Falvo, M. R.
name: Griffith, J. D.
name: Dismuke, D. J.
name: Asokan, A.
name: Horowitz, E. D.
name: Rahman, K. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We describe biophysical and ultrastructural differences in genome release from adeno-associated virus (AAV) capsids packaging wild-type DNA, recombinant single-stranded DNA (ssDNA), or dimeric, self-complementary DNA (scDNA) genomes. Atomic force microscopy and electron microscopy (EM) revealed that AAV particles release packaged genomes and undergo marked changes in capsid morphology upon heating in physiological buffer (pH 7.2). When different AAV capsids packaging ss/scDNA varying in length from 72 to 123% of wild-type DNA (3.4 to 5.8 kb) were incrementally heated, the proportion of uncoated AAV capsids decreased with genome length as observed by EM. Genome release was further characterized by a fluorimetric assay, which demonstrated that acidic pH and high osmotic pressure suppress genome release from AAV particles. In addition, fluorimetric analysis corroborated an inverse correlation between packaged genome length and the temperature needed to induce uncoating. Surprisingly, scAAV vectors required significantly higher temperatures to uncoat than their ssDNA-packaging counterparts. However, externalization of VP1 N termini appears to be unaffected by packaged genome length or self-complementarity. Further analysis by tungsten-shadowing EM revealed striking differences in the morphologies of ssDNA and scDNA genomes upon release from intact capsids. Computational modeling and molecular dynamics simulations suggest that the unusual thermal stability of scAAV vectors might arise from partial base pairing and optimal organization of packaged scDNA. Our work further defines the biophysical mechanisms underlying adeno-associated virus uncoating and genome release.
Electrochemical Impedance Spectroscopy for the on-board diagnosis of PEMFC via on-line identification of Equivalent Circuit Model parameters
Creators: name: (:Unkn) Unknown
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: ING-IND/08 MACCHINE A FLUIDO

description: 2012 - 2013
description: Proton Exchange Membrane, also named Polymer Electrolyte Membrane fuel cells (PEMFC) are interesting devices for energy conversion. Their development is due to the high efficiency, acceptable power density, quick start-up and good environmental compatibility. On the other hand, reliability cost and durability are the main challenges for PEM fuel cell commercialization. In 2010 the American Department of Energy (DoE) sets a target of 40000 hours for stationary and 5000 hours for automotive applications, respectively. Actually, these standards are considered as the mainly reference in fuel cell research. Based on electro-catalytic reactions, the PEMFC operation is influenced by system functioning conditions. In case of system operation in abnormal conditions several chemical, mechanical and thermal degradation mechanisms could take place inside the cell. Among other, improper water, thermal and gas managements can introduce a cell voltage drop, thus reducing the system performance. A long-term exposure to these phenomena causes the PEMFC lifetime reduction. Thus, a good system management is one of the primary targets to ensure suitable PEMFC durability. For this purpose, research activities are oriented towards the development of newest advanced monitoring and diagnostic algorithms. The primary goal is monitoring the system operation ensuring a correct system control. Moreover, the diagnostic tool (i.e. both algorithm and sensors) allows the detection of system component malfunctioning; it can isolate one or more faults that may have occurred causing the abnormal behaviour of the system operation... [edited by Author]
Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions
Creators: name: Agbandje-McKenna, M.
name: Samulski, R. J.
name: DiMattia, M. A.
name: Weichert, W. S.
name: Bennett, A.
name: Miller, E. B.
name: McKenna, R.
name: Kozyreva, O. G.
name: Olson, N. H.
name: Sinkovits, R. S.
name: Chiorini, J. A.
name: Gurda, B. L.
name: Nelson, C. D.
name: Zolotutkhin, S.
name: Baker, T. S.
name: Chen, W.-j.
name: Parrish, C. R.
name: Muzyczka, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Interactions between viruses and the host antibody immune response are critical in the development and control of disease, and antibodies are also known to interfere with the efficacy of viral vector-based gene delivery. The adeno-associated viruses (AAVs) being developed as vectors for corrective human gene delivery have shown promise in clinical trials, but preexisting antibodies are detrimental to successful outcomes. However, the antigenic epitopes on AAV capsids remain poorly characterized. Cryo-electron microscopy and three-dimensional image reconstruction were used to define the locations of epitopes to which monoclonal fragment antibodies (Fabs) against AAV1, AAV2, AAV5, and AAV6 bind. Pseudoatomic modeling showed that, in each serotype, Fabs bound to a limited number of sites near the protrusions surrounding the 3-fold axes of the T=1 icosahedral capsids. For the closely related AAV1 and AAV6, a common Fab exhibited substoichiometric binding, with one Fab bound, on average, between two of the three protrusions as a consequence of steric crowding. The other AAV Fabs saturated the capsid and bound to the walls of all 60 protrusions, with the footprint for the AAV5 antibody extending toward the 5-fold axis. The angle of incidence for each bound Fab on the AAVs varied and resulted in significant differences in how much of each viral capsid surface was occluded beyond the Fab footprints. The AAV-antibody interactions showed a common set of footprints that overlapped some known receptor-binding sites and transduction determinants, thus suggesting potential mechanisms for virus neutralization by the antibodies.
Change in Hepatitis B Virus Large Surface Antigen Variant Prevalence 13 Years after Implementation of a Universal Vaccination Program in China
Creators: name: Shen, L.
name: Wang, F.
name: Zhang, S.
name: Zhang, S.
name: Yan, H.
name: Cao, Y.
name: Bi, S.
name: Zhang, Y.
name: Bian, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A nationwide hepatitis B virus (HBV) vaccination program was implemented in China starting in 1992. To study the change in HBV variant prevalence with massive immunization, large HBV surface protein (LHBs) genes from HBV surface antigen (HBsAg)-positive sera were amplified and sequenced. The prevalences of LHBs mutants were compared between the 1992 and 2005 surveys in child and adult groups. The prevalence of “α” determinant mutants in the children increased from 6.5% in 1992 to 14.8% in 2005, where the G145R mutant occurred most frequently. In contrast, mutation frequencies showed little difference between 1992 (9.4%) and 2005 (9.9%) in adults. Moreover, compared to the 1992 survey, the child group surface (S) protein mutation frequency specifically increased (P = 0.005) in the 2005 survey, but the pre-S region mutation frequency did not show a significant difference (P > 0.05). However, the mutation frequency in the adult group increased in both the pre-S and S regions. Furthermore, the frequencies of the disease-related pre-S2 deletion and start codon mutations were significantly higher in the adult groups than in the child groups in both the 1992 and 2005 surveys (P < 0.01). Massive immunization enhances the HBV S protein mutation; the prevalence of LHBs mutants, particularly disease-related mutants, tends to increase with patient age.
Fundamental Cosmology from Precision Spectroscopy: I. Varying Couplings
Creators: name: Leite, A. C. O.
name: Martins, C. J. A. P.
name: Pedrosa, P. O. J.
name: Nunes, N. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The observational evidence for the acceleration of the universe demonstrates that canonical theories of cosmology and particle physics are incomplete, if not incorrect, and that new physics is out there, waiting to be discovered. Forthcoming high-resolution ultra-stable spectrographs will play a crucial role in this quest for new physics, by enabling a new generation of precision consistency tests. Here we focus on astrophysical tests of the stability of nature's fundamental couplings, and by using Principal Component Analysis techniques further calibrated by existing VLT data we discuss how the improvements that can be expected with ESPRESSO and ELT-HIRES will impact on fundamental cosmology. In particular we show that a 20 to 30 night program on ELT-HIRES will allow it to play a leading role in fundamental cosmology.
description: Phys. Rev. D (in press)
New Family of Robust 2D Topological Insulators in van der Waals Heterostructures
Creators: name: Kou, Liangzhi
name: Wu, Shu-Chun
name: Felser, Claudia
name: Frauenheim, Thomas
name: Chen, Changfeng
name: Yan, Binghai
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We predict a new family of robust two-dimensional (2D) topological insulators in van der Waals heterostructures comprising graphene and chalcogenides BiTeX (X=Cl, Br and I). The layered structures of both constituent materials produce a naturally smooth interface that is conducive to proximity induced new topological states. First principles calculations reveal intrinsic topologically nontrivial bulk energy gaps as large as 70-80 meV, which can be further enhanced up to 120 meV by compression. The strong spin-orbit coupling in BiTeX has a significant influence on the graphene Dirac states, resulting in the topologically nontrivial band structure, which is confirmed by calculated nontrivial Z2 index and an explicit demonstration of metallic edge states. Such heterostructures offer an unique Dirac transport system that combines the 2D Dirac states from graphene and 1D Dirac edge states from the topological insulator, and it offers new ideas for innovative device designs.
Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design
Creators: name: Lee, B.
name: Keys, J.
name: Gao, F.
name: Joseph, S. B.
name: Ngandu, N.
name: Hoffman, I.
name: Chu, H.
name: Anderson, J. A.
name: Kirchherr, J.
name: Ping, L.-H.
name: Moore, P.
name: Kincer, L. P.
name: Abrahams, M.-R.
name: Treurnicht, F. K.
name: Mapanje, C.
name: Zhang, M.
name: Iyer, S.
name: Vermeulen, M.
name: Salazar-Gonzalez, J. F.
name: Labranche, C.
name: Fiscus, S.
name: Karim, S. A.
name: Salazar, M. G.
name: Jabara, C.
name: Morris, L.
name: Ojeda, S.
name: Haynes, B. F.
name: Arney, L.
name: Seoighe, C.
name: Saville, A.
name: Potter, E. L.
name: Tang, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Understanding human immunodeficiency virus type 1 (HIV-1) transmission is central to developing effective prevention strategies, including a vaccine. We compared phenotypic and genetic variation in HIV-1 env genes from subjects in acute/early infection and subjects with chronic infections in the context of subtype C heterosexual transmission. We found that the transmitted viruses all used CCR5 and required high levels of CD4 to infect target cells, suggesting selection for replication in T cells and not macrophages after transmission. In addition, the transmitted viruses were more likely to use a maraviroc-sensitive conformation of CCR5, perhaps identifying a feature of the target T cell. We confirmed an earlier observation that the transmitted viruses were, on average, modestly underglycosylated relative to the viruses from chronically infected subjects. This difference was most pronounced in comparing the viruses in acutely infected men to those in chronically infected women. These features of the transmitted virus point to selective pressures during the transmission event. We did not observe a consistent difference either in heterologous neutralization sensitivity or in sensitivity to soluble CD4 between the two groups, suggesting similar conformations between viruses from acute and chronic infection. However, the presence or absence of glycosylation sites had differential effects on neutralization sensitivity for different antibodies. We suggest that the occasional absence of glycosylation sites encoded in the conserved regions of env, further reduced in transmitted viruses, could expose specific surface structures on the protein as antibody targets.
Chiral 2D "Strange Metals" from N = 4 SYM
Creators: name: Berkooz, Micha
name: Narayan, Prithvi
name: Zait, Amir
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Familiar field theories may contain closed subsectors made out of only fermions, which can be used to explore new and unusual phases of matter in lower dimensions. We focus on the fermionic su(1,1) sector in N=4 SYM and on its ground states, which are Fermi surface states/operators. By computing their spectrum to order $(g_{YM}^2 N)^2$, we argue that fluctuations around this fermi surface, within the sector and in the limit $k_F\rightarrow\infty$, are governed by a chiral 1+1 dimensional sector of the "strange metal" coset $SU(N)_N \otimes SU(N)_N/SU(N)_{2N}$. On the gravity side, the conjectured dual configuration is an $S=0$ degeneration of a rotating black hole. On general grounds we expect that the near horizon excitations of $(S=0,Ω=1,J\rightarrow\infty)$ degenerations of black holes will be governed by a chiral sector of a 1+1 CFT.
description: 44 pages
Pemetaan Topik Penelitian Seputar Akad Ijarah pada Industri Keuangan Syariah: Studi Bibliometrik VOSviewer dan Literature Review
Creators: name: Baranuri, Muhammad Yusrin
name: Budianto, Eka Wahyu Hestya
name: Dewi, Nindi Dwi Tetria
Publisher: name: Zenodo
Year: 2023
Subjects: Akad Ijarah
Industri Keuangan Syariah
Bibliometrik
VOSviewer
Literature Review

description: Penelitian ini bertujuan untuk mengetahui pemetaan topik penelitian seputar akad Ijarah pada Industri Keuangan Syariah dengan pendekatan mix-method, yaitu studi bibliometrik VOSviewer dan literature review. Teknik analisis data meliputi: (1) memetakan jumlah sebaran publikasi jurnal seputar akad Ijarah; (2) memetakan hasil visualisasi bibliometrik VOSviewer seputar akad Ijarah berdasarkan jumlah kluster dan itemnya; dan (3) memetakan topik penelitian seputar akad Ijarah menggunakan studi literature review. Hasil penelitian menunjukkan bahwa: (1) berdasarkan pemetaan jumlah sebaran publikasi jurnal, terdapat 295 publikasi jurnal seputar akad Ijarah; (2) berdasarkan pemetaan studi bibliometrik VOSviewer, hasil visualisasi jaringan seputar akad Ijarah terbagi menjadi 5 kluster dan 125 item topik; (3) berdasarkan pemetaan studi literature review, terdapat 10 topik utama seputar akad Ijarah. Perbedaan penelitian ini dengan penelitian sebelumnya adalah pada penelitian ini menjelaskan dan memetakan seluruh topik penelitian seputar akad Ijarah, sehingga peneliti selanjutnya dapat mengetahui kekosongan penelitian seputar akad Ijarah. Implikasi dan kontribusi penelitian ini adalah adanya pemetaan topik-topik penelitian seputar akad Ijarah yang sering ataupun jarang diteliti oleh peneliti, sehingga dapat menjadi rujukan bagi peneliti selanjutnya.
Contrasting Roles of Mitogen-Activated Protein Kinases in Cellular Entry and Replication of Hepatitis C Virus: MKNK1 Facilitates Cell Entry
Creators: name: Foung, S.
name: Kim, S.
name: Lemon, S. M.
name: Yamane, D.
name: Ishida, H.
name: Yi, M.
name: Swinney, D. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The human kinome comprises over 800 individual kinases. These contribute in multiple ways to regulation of cellular metabolism and may have direct and indirect effects on virus replication. Kinases are tempting therapeutic targets for drug development, but achieving sufficient specificity is often a challenge for chemical inhibitors. While using inhibitors to assess whether c-Jun N-terminal (JNK) kinases regulate hepatitis C virus (HCV) replication, we encountered unexpected off-target effects that led us to discover a role for a mitogen-activated protein kinase (MAPK)-related kinase, MAPK interacting serine/threonine kinase 1 (MKNK1), in viral entry. Two JNK inhibitors, AS601245 and SP600125, as well as RNA interference (RNAi)-mediated knockdown of JNK1 and JNK2, enhanced replication of HCV replicon RNAs as well as infectious genome-length RNA transfected into Huh-7 cells. JNK knockdown also enhanced replication following infection with cell-free virus, suggesting that JNK actively restricts HCV replication. Despite this, AS601245 and SP600125 both inhibited viral entry. Screening of a panel of inhibitors targeting kinases that may be modulated by off-target effects of AS601245 and SP600125 led us to identify MKNK1 as a host factor involved in HCV entry. Chemical inhibition or siRNA knockdown of MKNK1 significantly impaired entry of genotype 1a HCV and HCV-pseudotyped lentiviral particles (HCVpp) in Huh-7 cells but had only minimal impact on viral RNA replication or cell proliferation and viability. We propose a model by which MKNK1 acts to facilitate viral entry downstream of the epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK), both of which have been implicated in the entry process.
Dendritic Cell Immunoreceptor Regulates Chikungunya Virus Pathogenesis in Mice
Creators: name: Ferris, M. T.
name: Long, K. M.
name: Gunn, B.
name: Trollinger, B.
name: Whitmore, A. C.
name: McGee, C.
name: Sempowski, G. D.
name: Heise, M. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for recent epidemic outbreaks of debilitating disease in humans. Alphaviruses are known to interact with members of the C-type lectin receptor family of pattern recognition proteins, and given that the dendritic cell immunoreceptor (DCIR) is known to act as a negative regulator of the host inflammatory response and has previously been associated with rheumatoid arthritis, we evaluated DCIR's role in response to CHIKV infection. Although we observed an increase in the proportion of dendritic cells at the site of CHIKV infection at 24 to 36 h postinfection, these cells showed decreased cell surface DCIR, suggestive of DCIR triggering and internalization. In vitro, bone marrow-derived dendritic cells from DCIR-deficient (DCIR−/−) mice exhibited altered cytokine expression following exposure to CHIKV. DCIR−/− mice exhibited more severe disease signs than wild-type C57BL6/J mice following CHIKV infection, including a more rapid and more severe onset of virus-induced edema and enhanced weight loss. Histological examination revealed that DCIR-deficient animals exhibited increased inflammation and damage in both the fascia of the inoculated foot and the ankle joint, and DCIR deficiency skewed the CHIKV-induced cytokine response at the site of infection at multiple times postinfection. Early differences in virus-induced disease between C57BL6/J and DCIR−/− mice were independent of viral replication, while extended viral replication correlated with enhanced foot swelling and tissue inflammation and damage in DCIR−/− compared to C57BL6/J mice at 6 to 7 days postinfection. These results suggest that DCIR plays a protective role in limiting the CHIKV-induced inflammatory response and subsequent tissue and joint damage.
SOUSA: the Swift Optical/Ultraviolet Supernova Archive
Creators: name: Brown, Peter J.
name: Breeveld, Alice A.
name: Holland, Stephen
name: Kuin, Paul
name: Pritchard, Tyler
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Ultra-Violet Optical Telescope on the Swift spacecraft has observed hundreds of supernovae, covering all major types and most subtypes. Here we introduce the Swift Optical/Ultraviolet Supernova Archive (SOUSA), which will contain all of the supernova images and photometry. We describe the observation and reduction procedures and how they impact the final data. We show photometry from well-observed examples of most supernova classes, whose absolute magnitudes and colors may be used to infer supernova types in the absence of a spectrum. A full understanding of the variety within classes and a robust photometric separation of the groups requires a larger sample, which will be provided by the final archive. The data from the existing Swift supernovae are also useful for planning future observations with Swift as well as future UV observatories.
description: Accepted for publication in the UV issue of Astrophysics and Space Science 10 pages, 6 figures SOUSA is an archive in progress with data being posted to the Swift SN website: http://swift.gsfc.nasa.gov/docs/swift/sne/swift_sn.html
Emergence of a Norovirus GII.4 Strain Correlates with Changes in Evolving Blockade Epitopes
Creators: name: Costantini, V.
name: Baric, R. S.
name: Vinje, J.
name: Swanstrom, J.
name: Debbink, K.
name: Donaldson, E. F.
name: Lindesmith, L. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The major capsid protein of norovirus GII.4 strains is evolving rapidly, resulting in epidemic strains with altered antigenicity. GII.4.2006 Minerva strains circulated at pandemic levels in 2006 and persisted at lower levels until 2009. In 2009, a new GII.4 variant, GII.4.2009 New Orleans, emerged and since then has become the predominant strain circulating in human populations. To determine whether changes in evolving blockade epitopes correlate with the emergence of the GII.4.2009 New Orleans strains, we compared the antibody reactivity of a panel of mouse monoclonal antibodies (MAbs) against GII.4.2006 and GII.4.2009 virus-like particles (VLPs). Both anti-GII.4.2006 and GII.4.2009 MAbs effectively differentiated the two strains by VLP-carbohydrate ligand blockade assay. Most of the GII.4.2006 MAbs preferentially blocked GII.4.2006, while all of the GII.4.2009 MAbs preferentially blocked GII.4.2009, although 8 of 12 tested blockade MAbs blocked both VLPs. Using mutant VLPs designed to alter predicted antigenic epitopes, binding of seven of the blockade MAbs was impacted by alterations in epitope A, identifying residues 294, 296, 297, 298, 368, and 372 as important antigenic sites in these strains. Convalescent-phase serum collected from a GII.4.2009 outbreak confirmed the immunodominance of epitope A, since alterations of epitope A affected serum reactivity by 40%. These data indicate that the GII.4.2009 New Orleans variant has evolved a key blockade epitope, possibly allowing for at least partial escape from protective herd immunity and provide epidemiological support for the utility of monitoring changes in epitope A in emergent strain surveillance.
New metal catalysts for the synthesis of polyolefins and bioderived polymers
Creators: name: Lapenta, Rosita
Publisher: name: Universita degli studi di Salerno
Year: 2018
Subjects: subject: CHIM/03 CHIMICA GENERALE E INORGANICA

description: 2016 - 2017
description: The aim of PhD project is the synthesis of new metal catalysts active in the polymerization of polar monomer and α-olefins. In the last decade, transition metal complexes bearing tetradentate bis(phenolato) ligands are widely studied for their high polymerization control and activity.1 The bis(phenolato) ligand is composed of two phenoxide groups linked by a bridge comprising two donor heteroatoms; when the donors are two sulfur atoms, the ligand is called of OSSO-type... [edited by Author]
Informations- und Kommunikationskonzept für CADMEC AG
Creators: name: Kuhn, Michael
Publisher: name: My University
Year: 2013
Subjects: subject: Information
subject: Kommunikation
subject: Konzept
subject: Informationskonzept
subject: Kommunikationskonzept
subject: Stakeholder
subject: Empfehlungen
subject: Medienarbeit
subject: Digitale Medien
subject: interne Kommunikation
subject: externe Kommunikation
subject: Digital Workplace
subject: Social Media
subject: Risikobeurteilung
subject: Kommunikationscontrolling
subject: Controlling
subject: 330 - Wirtschaft
subject: 659 - Werbung & Public Releations (PR)

description: Ein strategisch durchdachtes Kommunikationskonzept ist für den Unternehmenserfolg enorm wichtig. Mit verstärkten Einzelmassnahmen können Wettbewerbsvorteile erreicht, Synergien genutzt und nicht zuletzt Kosten eingespart werden. Oft helfen einfache Massnahmen, um diese Ziele zu erreichen. (Beitrag ist nur für FHNW Mitarbeitende sichtbar)
Additional file 1 of Implementation of a medicine management plan (MMP) to reduce medication-related harm (MRH) in older people post-hospital discharge: a randomised controlled trial
Creators: name: Ali, Khalid
name: Mensah, Ekow A.
name: McDermott, Eugene Ace
name: Kirkham, Frances A.
name: Stevenson, Jennifer
name: Hamer, Victoria
name: Parekh, Nikesh
name: Schiff, Rebekah
name: Van Der Cammen, Tischa
name: Nyangoma, Stephen
name: Fowler-Davis, Sally
name: Davies, Graham
name: Gage, Heather
name: Rajkumar, Chakravarthi
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Appendix 1. Formula for calculating patient risk of experiencing MRH within 8 weeks post hospital discharge. Appendix 2. Visual analogue of risk prediction tool. Appendix 3. Study participants flow chart.
International Sanctions of the European Union in Search of Effectiveness and Accountability
Creators: name: Rizzo, Alfredo
Publisher: name: Universita' degli Studi di Salerno
Year: 2022
Subjects: International sanctions
Judicial Cooperation on criminal law
Noncontractual liability
Global Human Rights Sanctions Regime

description: The paper investigates how the effectiveness of the European Union’s action and its accountability are tackled in the field of international sanctions regimes. This is particularly meaningful for sanctions targeting individuals and private companies, considering the negative outcomes that international sanctions have, sometimes even just indirectly, on both. While, on the one hand, the Court of Justice of the EU has expanded the right to claim damages that individuals might suffer from sanctions, the enactment of more general regimes (such as the Global human rights sanctions regime) might have adverse effects on those individuals’ defense rights. In this context, the Commission is in search of solutions to provide the Union’s sanctions with full effectiveness also by means of criminal procedural law tools.
Herschel/PACS Observations of the Host Galaxy of GRB 031203
Creators: name: Symeonidis, M.
name: Oates, S. R.
name: de Pasquale, M.
name: Page, M. J.
name: Wiersema, K.
name: Starling, R.
name: Schady, P.
name: Seymour, N.
name: O'Halloran, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present Herschel/PACS observations of the nearby (z=0.1055) dwarf galaxy that has hosted the long gamma ray burst (LGRB) 031203. Using the PACS data we have been able to place constraints on the dust temperature, dust mass, total infrared luminosity and infrared-derived star-formation rate (SFR) for this object. We find that the GRB host galaxy (GRBH) 031203 has a total infrared luminosity of 3x10^10 L_sun placing it in the regime of the IR-luminous galaxy population. Its dust temperature and specific SFR are comparable to that of many high-redshift (z=0.3-2.5) infrared (IR)-detected GRB hosts (T_dust>40K ; sSFR>10 Gyr^-1), however its dust-to-stellar mass ratio is lower than what is commonly seen in IR-luminous galaxies. Our results suggest that GRBH 031203 is undergoing a strong starburst episode and its dust properties are different to those of local dwarf galaxies within the same metallicity and stellar mass range. Furthermore, our measurements place it in a distinct class to the well studied nearby host of GRB 980425 (z=0.0085), confirming the notion that GRB host galaxies can span a large range in properties even at similar cosmological epochs, making LGRBs an ideal tool in selecting samples of star-forming galaxies up to high redshift.
description: 5 pages, 6 figures, accepted for publication in MNRAS
Epstein-Barr Virus Latent Membrane Protein 2 Effects on Epithelial Acinus Development Reveal Distinct Requirements for the PY and YEEA motifs
Creators: name: Raab-Traub, N.
name: Fotheringham, J. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Epstein-Barr virus (EBV) is a gammaherpesvirus associated with numerous cancers, including the epithelial cancers nasopharyngeal carcinoma (NPC) and gastric carcinoma. The latent membrane protein 2 (LMP2) encoded by EBV is consistently detected in NPC tumors and promotes a malignant phenotype when expressed in epithelial cells by inducing transformation and migration and inhibiting differentiation. Grown in three dimensions (3D) on Matrigel, the nontumorigenic mammary epithelial cell line MCF10A forms hollow, spherical acinar structures that maintain normal glandular features. Expression of oncogenes in these cells allows for the study of multiple aspects of tumor development in a 3D culture system. This study sought to examine the effects of LMP2 on the generation of MCF10A acini. LMP2 expression induced abnormal acini that were large, misshapen, and filled, indicating that LMP2 induced proliferation, impaired cellular polarization, and induced resistance to cell death, leading to luminal filling. Induction of cell death resistance required the PY, immunoreceptor tyrosine activation motif (ITAM), and YEEA signaling domains of LMP2 and activation of the Src and Akt signaling pathways. The PY domain was required for the inhibition of anoikis and also the delayed proliferative arrest of the LMP2-expressing cells. In addition to directly altering acinus formation, expression of LMP2 also induced morphological and protein expression changes consistent with epithelial-mesenchymal transition (EMT) in a manner that required only the YEEA signaling motif of LMP2. These findings indicate that LMP2 has considerable transforming properties that are not evident in standard tissue culture and requires the ability of LMP2A to bind ubiquitin ligases and Src family kinases.
Epstein-Barr Virus LMP1 Modulates Lipid Raft Microdomains and the Vimentin Cytoskeleton for Signal Transduction and Transformation
Creators: name: Raab-Traub, N.
name: Meckes, D. G.
name: Menaker, N. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The Epstein-Barr virus (EBV) is an important human pathogen that is associated with multiple cancers. The major oncoprotein of the virus, latent membrane protein 1 (LMP1), is essential for EBV B-cell immortalization and is sufficient to transform rodent fibroblasts. This viral transmembrane protein activates multiple cellular signaling pathways by engaging critical effector molecules and thus acts as a ligand-independent growth factor receptor. LMP1 is thought to signal from internal lipid raft containing membranes; however, the mechanisms through which these events occur remain largely unknown. Lipid rafts are microdomains within membranes that are rich in cholesterol and sphingolipids. Lipid rafts act as organization centers for biological processes, including signal transduction, protein trafficking, and pathogen entry and egress. In this study, the recruitment of key signaling components to lipid raft microdomains by LMP1 was analyzed. LMP1 increased the localization of phosphatidylinositol 3-kinase (PI3K) and its activated downstream target, Akt, to lipid rafts. In addition, mass spectrometry analyses identified elevated vimentin in rafts isolated from LMP1 expressing NPC cells. Disruption of lipid rafts through cholesterol depletion inhibited PI3K localization to membranes and decreased both Akt and ERK activation. Reduction of vimentin levels or disruption of its organization also decreased LMP1-mediated Akt and ERK activation and inhibited transformation of rodent fibroblasts. These findings indicate that LMP1 reorganizes membrane and cytoskeleton microdomains to modulate signal transduction.
Additional file 1 of Physiotherapists’ knowledge of and adherence to evidence-based practice guidelines and recommendations for ankle sprains management: a cross-sectional study
Creators: name: Caffini, Giulia
name: Battista, Simone
name: Raschi, Andrea
name: Testa, Marco
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1.
Immune Activation and Regulation in Simian Immunodeficiency Virus-Plasmodium fragile-Coinfected Rhesus Macaques
Creators: name: Hudgens, M. A.
name: Richardson, A.
name: Trott, K. A.
name: Abel, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Human immunodeficiency virus (HIV) is characterized by immune activation, while chronic malaria is associated with elevated interleukin-10 (IL-10) levels. How these apparently antagonizing forces interact in the coinfected host is poorly understood. Using a rhesus macaque model of simian immunodeficiency virus (SIV)-Plasmodium fragile coinfection, we evaluated how innate immune effector cells affect the balance between immune activation and regulation. In vitro Toll-like receptor (TLR) responses of peripheral blood myeloid dendritic cells (mDC) and monocytes were temporarily associated with acute parasitemic episodes and elevated plasma IL-10 levels. Prolonged infection resulted in a decline of mDC function. Monocytes maintained TLR responsiveness but, in addition to IL-12 and tumor necrosis factor alpha, also produced IL-10. Consistent with the role of spleen in the clearance of parasite-infected red blood cells, coinfected animals also had increased splenic IL-10 mRNA levels. The main cellular source of IL-10 in the spleens of coinfected animals, however, was not splenic macrophages but T cells, suggesting an impairment of adaptive immunity. In contrast to those in spleen, IL-10-positive cells in axillary lymph nodes of coinfected animals were predominantly mDC, reminiscent of the immunosuppressive phenotype of peripheral blood mDC. Concurrent with IL-10 induction, however, SIV infection promoted elevated systemic IL-12 levels. The continuously increasing ratio of plasma IL-12 to IL-10 suggested that the overall host response in SIV-P. fragile-coinfected animals was shifted toward immune activation versus immune regulation. Therefore, SIV-P. fragile coinfection might be characterized by earlier manifestation of immune dysfunction and exhaustion than that of single-pathogen infections. This could translate into increased morbidity in HIV-malaria-coinfected individuals.
Additional file 2 of Physiotherapists’ knowledge of and adherence to evidence-based practice guidelines and recommendations for ankle sprains management: a cross-sectional study
Creators: name: Caffini, Giulia
name: Battista, Simone
name: Raschi, Andrea
name: Testa, Marco
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2.