cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comments on boundary driven open XXZ chain: asymmetric driving and uniqueness of steady states
Creators: name: Prosen, Tomaz
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this short note we provide two extensions on the recent explicit results on the matrix-product ansatz for the non-equilibrium steady state of a markovianly boundary-driven anisotropic Heisenberg XXZ spin 1/2 chain. We write a perturbative solution for the steady state density matrix in the system-batyh coupling for an arbitrary (asymmetric) set of four spin-flip rates at the two chain ends, generalizing the symmetric-driving ansatz of [Phys. Rev. Lett. 106, 217206 (2011)]. Furthermore, we generalize the exact (non-perturbative) form of the steady state for just two Lindblad channels (spin-up flipping on the left, and spin-down flipping on the right) to an arbitrary (asymmetric) ratio of the spin flipping rates [Phys. Rev. Lett. 107, 137201 (2011)]. In addition, we also indicate a simple proof of uniqueness of our steady states.
description: Contribution for the comment section of Physica Scripta on the Nordita program "Foundations and Applications of Non-equilibrium Statistical Mechanics". v2: formulas (32) and (39) corrected w.r.t. published version (typos pointed out by Enej Ilievski and Bojan Zunkovic)
Untersuchungen zur Fibrillenbildung unter Berücksichtigung einer benachbarten gefalteten Domäne
Creators: name: Sackewitz, Mirko
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571.94633
subject: 570

description: Krankheiten, die durch Fehlfaltungen von Proteinen gekennzeichnet sind oder dadurch hervorgerufen werden, werden als Protein-Missfaltungskrankheiten bezeichnet. Zu diesen Proteinmissfaltungs-Krankheiten werden auch Erkrankungen wie die Alzheimersche- und Parkinsonsche Krankheit oder die Spongioformen Encephalopathien gezählt. Die Krankheit OPMD (Oculopharyngeale Muskeldystrophie) hat ihren Ursprung in einer Expansion einer N-terminalen Poly-Alanin-Sequenz im Protein PABPN1 (Nukleäres Poly(A)-bindendes Protein 1). Frühere Untersuchungen haben gezeigt, dass derartige Expansionen zur Missfaltung von PABPN1 in vivo führen und die „nativ ungefaltete“ N-terminale Domäne in vitro amyloide Fibrillen bildet. Um den Einfluss eines stabil gefalteten Proteins auf die poly-alanin-induzierte Fibrillenbildung zu untersuchen, wurden in der vorliegenden Arbeit Fusionsproteine hergestellt und biophysikalisch charakterisiert. Einerseits wurden Fusionen aus N-terminaler Domäne von PABPN1 und dem Kälteschockprotein B aus B. subtilis (CspB) und andererseits Fusionen aus Poly-Alaninen und CspB analysiert. Alle rekombinant hergestellten, löslichen Fusionen enthielten CspB in nativer Konformation. Die drei Fusionen aus N-terminaler Domäne und CspB, N-(+7)Ala-CspB mit 17 Alaninen (krankheitsassoziiert), N-WT-CspB mit 10 Alaninen (Wildtyp) und N-ΔAla-CspB ohne Poly-Alanin-Segment (Deletionsvariante), zeigten eine von der Poly-Alanin-Sequenz abhängige Fibrillenbildung. Obwohl die Fibrillenbildung eine Konformationsänderung mit einem Übergang vom löslichen zu einem unlöslichen Zustand darstellt, konnte in den Fibrillen von N-(+7)Ala-CspB natives CspB nachgewiesen werden. Für die „direkten Fusionen“ aus Poly-Alaninen und CspB wurde lediglich für die Variante 10Ala-CspB, nicht jedoch für die Variante 17Ala-CspB, eindeutig eine Fibrillenbildung gezeigt. Die Fibrillenbildung wurde begleitet von der Bildung amorpher Strukturen. Die Fibrillen von 10Ala-CspB enthielten kein natives CspB. Dies ist vermutlich auf den fehlenden Spacer zwischen Poly-Alaninen und CspB zurückzuführen. Die für die Fibrillenstrukturen verantwortlichen Aminosäuresequenzen wurden mittels proteolytischem Verdau, HPLC und Massenspektrometrie bestimmt.
Charakterisierung des Transport- und Assemblierungsverhaltens der Ferritine aus Arabidopsis thaliana
Creators: name: Sondermann, Manuela
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2009
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 571.6572364
subject: 570

description: Ferritine sind Eisen-speichernde Proteine, welche in Pflanzen in den Chloroplasten vorliegen. Da kürzlich aber auch eine mitochondrielle Lokalisierung beschrieben wurde (Zancani et al., 2004), wurde die subzelluläre Lokalisierung der vier kerncodierten Ferritine aus Arabidopsis thaliana (AtFer1-AtFer4) mittels in vitro Proteintransportexperimenten mit isolierten Organellen untersucht. Alle vier Ferritine zeigten dual targeting-Verhalten, d.h. sie wurden sowohl in Chloroplasten als auch in Mitochondrien importiert. Innerhalb der Chloroplasten waren alle vier Ferritine in der Lage, zu multimeren Strukturen zu assemblieren, welche vermutlich funktionelle Ferritinkomplexe darstellen. Bemerkenswert ist, dass diese Komplexe für zwei der Ferritine auch nach dem Import in die Mitochondrien nachgewiesen werden konnten. In einem komplementären Ansatz wurde die subzelluläre Lokalisierung von zwei Arabidopsis-Ferritinen mittels chimärer Reporterproteine, welche das fluoreszierende EYFP tragen, untersucht. Während die chimären Proteine im in vitro-Importansatz wiederum dual targeting-Verhalten zeigten, konnten sie nach transienter Transformation mittels particle gun ausschließlich in den Plastiden der transformierten Zellen detektiert werden. Zur Aufklärung dieser Diskrepanz zwischen den in vitro- und in vivo-Daten sind weiterführende Analysen erforderlich.
Unconventional Monetary Policy in the Euro Area: A Tale of Three Shocks
Creators: name: Fanelli, Luca
name: Marsi, Antonio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2021
Subjects: SECS-P/05 Econometria

description: High-frequency (HF) surprises of relevant asset prices around central bank meetings are extensively employed in the literature to identify the effects of conventional/unconventional monetary policy. This identification strategy assumes that these surprises reflect either a single unconventional ‘monetary shock’ or, as recently suggested, jointly an unconventional monetary shock and a central bank ‘information shock’. In this paper we show that monetary policy in the euro area after 2008 is best characterized by three shocks, not two. Besides the unconventional monetary shock and the information shock, we consider a third shock resulting from the ECB directly managing fragmentation risk in the sovereign bond market. We call this additional shock ‘spread shock’, and show that it permits to solve a puzzle we observe in HF comovement of long term risk free rates and sovereign spreads around press conferences. We identify the dynamic causal effects produced by the three shocks through a proxy-SVAR methodology which, using HF surprises of the euro area risk-free yield curve, stock prices and sovereign spreads, combines sign-restrictions with narrative restrictions and then extracts external variables (instruments) from an admissible identification set. Empirical results, obtained through a daily proxy-SVAR and Local Projections based on monthly data, reveal that the spread shock represents an important ingredient of the transmission mechanism of the monetary policy after the Global Financial Crisis. It reflects ECB’s attempt to offset self-fulling expectations of default in the euro area sovereign debt markets and behaves as a complement, not a substitute of the information shock.
Note on the Stabilities of the Light-like Galileon Solutions
Creators: name: Zhou, Shuang-Yong
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Light-like galileon solutions have been used to investigate the chronology problem in galileon-like theories, and in some cases may also be considered as solitons, evading a non-existence constraint from a zero-mode argument. Their stabilities have been analyzed via "local" approximation, which appears to suggest that all these light-like solutions are stable. We re-analyze the stability problem by solving the linear perturbation equation \emph{exactly}, and point out that the finite energy condition is essential for the light-like solitons to be stable. We also clarify potential ghost instabilities and why the zero-mode argument can not be naively generalized to include the light-like solitons.
description: 6 pages, minor improvement of wording in page 3
Hamilton decompositions of regular expanders: applications
Creators: name: Kühn, Daniela
name: Osthus, Deryk
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C45, 05C35, 05C70, 05C80, 05C20

description: In a recent paper, we showed that every sufficiently large regular digraph G on n vertices whose degree is linear in n and which is a robust outexpander has a decomposition into edge-disjoint Hamilton cycles. The main consequence of this theorem is that every regular tournament on n vertices can be decomposed into (n-1)/2 edge-disjoint Hamilton cycles, whenever n is sufficiently large. This verified a conjecture of Kelly from 1968. In this paper, we derive a number of further consequences of our result on robust outexpanders, the main ones are the following: (i) an undirected analogue of our result on robust outexpanders; (ii) best possible bounds on the size of an optimal packing of edge-disjoint Hamilton cycles in a graph of minimum degree d for a large range of values for d. (iii) a similar result for digraphs of given minimum semidegree; (iv) an approximate version of a conjecture of Nash-Williams on Hamilton decompositions of dense regular graphs; (v) the observation that dense quasi-random graphs are robust outexpanders; (vi) a verification of the `very dense' case of a conjecture of Frieze and Krivelevich on packing edge-disjoint Hamilton cycles in random graphs; (vii) a proof of a conjecture of Erdos on the size of an optimal packing of edge-disjoint Hamilton cycles in a random tournament.
description: final version, to appear in J. Combinatorial Theory B
Einfluss des Weichmachers Di(2-ethylhexyl)phthalat auf die Adipogenese einer humanen Präadipozytenlinie
Creators: name: Hunger, Luise
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2015
Subjects: subject: 611

description: Der Weichmacher Di(2-ethylhexyl)phthalat (DEHP) steht unter Verdacht, obesogen auf den Menschen zu wirken. Ziel der Studie ist es, das obesogene Potenzial von DEHP in humaner Zellkultur zu untersuchen. Zellen der humanen Präadipozytenlinie Simpson-Golabi-Behmel-Syndrom (SGBS) wurden über 14 Tage zu reifen Adipozyten differenziert und während der Induktionsphase mit DEHP in umweltrelevanter Konzentration von 50 μg/ml exponiert. Die Hydrolyse von DEHP zu Mono(2-ethylhexyl)phthalat (MEHP) wurde mit HPLC-Massenspektrometrie nachgewiesen, die Dysregulation der Adiponektinsignalkaskade mit qRT-PCR, Western-Blot und ELISA analysiert, die Frage einer DEHP-induzierten Hypertrophie oder Hyperplasie mit FACS beantwortet und die intrazelluläre Lage von Perilipin und GLUT4 mit Immunfluoreszenz ermittelt. Die Gene Adiponektin, AMPK und ACACB waren an Tag 4 dysreguliert, die Proteinsynthese und -sekretion von LEPTIN im Gegensatz zu ADIPONEKTIN langfristig erhöht, und die Fetteinlagerung unter DEHP an Tag 8 signifikant erhöht. Diese Ergebnisse zeigen, dass DEHP ein obesogenes Potenzial auf SGBS-Zellen hat.
description: The plasticizer di-2-ethylhexyl phthalate (DEHP) is suspected to act as an obesogen on human beings. Aim of this study is to examine the obesogen potential of DEHP in human cell culture. Cells of the human preadipocyte cell line Simpson-Golabi-Behmel syndrome (SGBS) were differentiated to mature adipocytes for 14 days and were exposed to DEHP in an environmentally relevant concentration of 50 μg/ml. The hydrolysis of DEHP to its metabolite monoethylhexyl phthalate (MEHP) was proven by use of HPLC-mass spectrometry. The dysregulation of the adiponectin signalling cascade was analysed with qRT-PCR, Western-Blot and ELISA. The question whether DEHP induces hypertrophy or hyperplasia was answered with FACS and the intracellular locations of perilipin and GLUT4 were detected by use of immunofluorescence. QRT-PCR showed a dysregulation of adiponectin, AMPK and ACACB at day 4. ELISAs of day 14 extracellular medium revealed a long-term elevated protein synthesis and secretion of LEPTIN, but not of ADIPONECTIN. Day 8 FACS analysis resulted in a DEHP-induced elevated fat storage. These findings show that DEHP has an obesogen potential on human SGBS cells.
Applications of capillary electrophoresis - mass spectrometry interfaced by a flow-thourgh microvial electrospray ionization sprayer
Creators: name: Zhao, Shuai Sherry
Publisher: name: University of British Columbia
Year: 2015

description: Capillary electrophoresis – electrospray ionization – mass spectrometry (CE-ESI-MS) combines the superior separation capability of CE and detection and characterization ability of MS. Different CE separation modes can be coupled to ESI-MS, employing an interface with a flow-through microvial. In the first part of the thesis, recent development of CE and CE-MS applications in the analysis of complex samples are reviewed. Capillary isoelectric focusing (cIEF) is an important tool for the separation and characterization of amphoteric molecules based on isoelectric points. Minute structural changes on a large protein can result in changes in isoelectric point, and the changes can be detected by slab gel isoelectric focusing or capillary isoelectric focusing. A systematic study on the interactions among carrier ampholytes, sample media and capillary inner coatings was carried out to provide guidelines for choosing feasible combinations that can achieve isoelectric focusing and successful chemical mobilizations. Within the 0.1%-1% (w/v) carrier ampholytes concentration range, small forward EOFs will ensure a higher chance of good focusing and successful electrophoretic mobilization, while a negative EOF will hinder these processes. Feasible combinations of experimental conditions are summarized. Using the optimized conditions, we reported the direct observation of the shape of focused ampholyte bands in the cIEF process by online cIEF- ESI-MS. The ampholyte bands directly detected by MS have the potential to enable a more accurate pI determination for unknown amphoteric molecules. Immunoglobulin G from rabbit serum is used to demonstrate this possibility. In Chapter 6, a CE-MS method was developed to monitor the concentration variations of major nutrients and/or metabolites in human embryonic stem cell CA1S culture medium over a culturing cycle. Concentration changes for nutrients and/or metabolites in the culturing media provided information on the cell growth behavior without destructing living cells. In the last part of the thesis, an atmospheric ion lens was applied to the flow-through microvial CE-ESI-MS interface to improve the electrospray ionization and sampling efficiency. A mixture of amino acids was tested to show the increased signal-to-noise ratios. The atmospheric ion lens also gives more flexibility when choosing the EOF and chemical modifier flow rates.
Epigenetische Kontrolle meiotischer Rekombination und Kartierung neuer Su(var)-Gene in Drosophila melanogaster
Creators: name: Gebhardt, Kathleen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 576

description: Die Neukombination väterlicher und mütterlicher Gene wird während der Meiose durch den Prozess der homologen Rekombination vermittelt. Heterochromatin hat als ein regulatorischer Aspekt meiotischer Rekombinationsprozesse einen negativen Effekt auf Crossover, wodurch eine signifikante Reduktion von Rekombinationsereignissen vor allem in heterochromatischen Bereichen stattfindet. Somit sollten Faktoren, die die Chromatinstruktur beeinflussen, folglich auch die Crossoverfrequenz verändern. Diese Faktoren können bei Drosophila melanogaster durch das System der Positionseffekt-Variegation (PEV) identifiziert werden. Eine Vielzahl der PEV-Faktoren zeigt in diesem Zusammenhang einen rekombinogenen Effekt auf das perizentrische Hetereochromatin. In der vorliegenden Arbeit sollen am Modellsystem Drosophila melanogaster mit Hilfe genetischer, immunzytologischer und molekularbiologischer Analysen epigenetische Prozesse aufgeklärt werden, die die meiotische Rekombination beeinflussen. Weiterhin wurden neue Kartierungsmethoden zur effizienten Identifizierung neuer epigenetischer Faktoren etabliert.
description: The new combination of paternal and maternal genes is arranged by the process of homologous recombination during meiosis. As its regulatory aspect of meiotic recombination heterochromatin has a negativ effect on crossover, whereby a significant reduction of crossover occur in heterochromatic regions. Consequently factors, which influence chromatin structure, should therefore also change crossover frequency. These factors can be identified by the system of position effect variegation (PEV) among Drosophila melanogaster. In connection with this, a variety of PEV factors show recombinogentic effects on pericentric heterochromatin. The present work consists in resolution of epigenetic processes controlling meiotic recombination by genetic, immunocytological and molecular analysis using the Drosophila melanogaster model system. Furthermore new mapping methods were established for efficient identification of new epigenetic factors.
Nilpotent coadjoint orbits in small characteristic
Creators: name: Xue, Ting
Publisher: name: arXiv
Year: 2011
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We show that the numbers of nilpotent coadjoint orbits in the dual of exceptional Lie algebra $G_2$ in characteristic $3$ and in the dual of exceptional Lie algebra $F_4$ in characteristic $2$ are finite. We determine the closure relation among nilpotent coadjoint orbits in the dual of Lie algebras of type $B,C,F_4$ in characteristic $2$ and in the dual of Lie algebra of type $G_2$ in characteristic $3$. In each case we give an explicit description of the nilpotent pieces in the dual defined in \cite{CP}, which are in general unions of nilpotent coadjoint orbits, coincide with the earlier case-by-case definition in \cite{L4,X4} in the case of classical groups and have nice properties independent of the characteristic of the base field. This completes the classification of nilpotent coadjoint orbits in the dual of Lie algebras of reductive algebraic groups and the determination of closure relation among such orbits in all characteristic.
The compatibility of thin-shell wormholes with quantum field theory
Creators: name: Kuhfittig, Peter K. F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It is shown in this paper that thin-shell wormholes, mathematically constructed by the standard cut-and-paste technique, can, under fairly general conditions, be compatible with quantum field theory.
description: Invited talk, International Conference on Dynamical Systems, Kolkata, India (January, 2012)
Die Wechselwirkungen zwischen (Endo-)Cannabinoiden und Mechanik bei der Tumorinvasion
Creators: name: Hohmann, Tim
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2018
Subjects: subject: 615

description: Biomechanische Eigenschaften von Einzelzellen enthalten Informationen über den Gesundheitszustand von Zellen. Bei Tumorzellen wurde beobachtet, dass sie ein geringeres Elastizitätsmodul besitzen, als Zellen ihres Ursprungsgewebes. Ob diese Änderung als potentieller prognostischer Marker verwendet werden könnten, ist jedoch gegenwärtig unklar. Diese Arbeit untersuchte, ob Veränderungen biomechanischer Eigenschaften einen Marker für die Invasivität darstellen. Es wurden fünf verschiedene Gliomzelllinien verwendet, die mit Cannabinoiden behandelt, bestrahlt wurden oder MACC1 bzw. eine IDH1 Mutation besitzen. Mechanische Eigenschaften wurden mittels Atomkraftmikroskopie gemessen und die Invasivität in einem Co-Kultur Modell. Es konnte eine negative Korrelation zwischen einer „verallgemeinerten Festigkeit" und der Invasivität der Tumorzellen ermittelt werden. Folglich könnte die „verallgemeinerten Elastizität" ein potentieller Marker für die Tumorinvasivität sein und daher auch eine mögliche klinische Relevanz besitzen.
description: Biomechanical properties of single cells provide information about the health state of a cell. In the case of tumour cells it was observed that these are softer than the cells of their healthy counter-part. Whether this is a potential prognostic marker remains unclear. The hypothesis whether biomechanical properties of cells represent a marker for the invasiveness of glioma cells was tested. Five different glioma cell lines were treated with cannabinoids, irradiated or transfected with MACC1 or an IDH1 mutation. Changes of mechanical properties of single cells were measured using atomic force microscopy. The invasiveness of cell lines was determined using a co-culture model. A negative correlation between a “generalized stiffness" and the invasiveness was observed. Consequently, the “generalized stiffness" might be a potential marker for the invasiveness of various glioma cell populations and thus of clinical relevance.
The targum (1871:Oct.)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1871

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Team-based approaches to psychosocial oncology care
Creators: name: Magtoto, Joanne
Publisher: name: University of British Columbia
Year: 2014

description: Background: While the health system in Canada recognizes the need for comprehensive cancer care, barriers must be overcome to achieve this goal. One is improving how professionals work together. This study explores social workers’ and counsellors’ experiences offering psychosocial cancer care as part of a cancer system that prioritizes medically related cancer care. My study objective is to increase understanding on how the health care system can better support team-based approaches in providing psychosocial cancer care for families faced with cancer. Methods: I explored, through a generic qualitative research methodology, the experiences of eight social workers or counsellors who utilize team-based approaches in psychosocial cancer care. Using a semi-structured interview approach, I asked each participant to describe their experiences with team-based approaches in cancer care. Findings: Findings are presented using the ecological systems perspective, with the themes representing micro, mezzo, and macro level facilitators and barriers to psychosocial cancer care within a team-based approach. The overarching theme identified by participants was the need for building authentic and close working relationships with their colleagues. At a micro level, relationships between cancer care providers was identified as an asset when working in an oncology setting facing larger system influences that detract from offering psychosocial cancer care. Within this overarching theme participants described the following mezzo and macro factors in facilitating or detracting from team-based approaches in offering psychosocial care: flexible infrastructure and resources, space, staff availability, medical dominance, and limited time and resources. Implications: Exploring team-based approaches in psychosocial cancer care is understudied in oncology and health system research. This study may fill some of this knowledge gap, specifically by highlighting the need for authentic and close relationships with colleagues especially in times of high and demanding workloads within an emotionally fatiguing work environment such as oncology. The participants’ experiences mirror the challenges identified in psychosocial oncology in Canada and future research may expand this study by developing theoretical frameworks for team-based approaches within a psychosocial oncology context, and by translating theory into cancer care practice that addresses the needs of mind, body, and soul.
Geometry of Spectral Curves and All Order Dispersive Integrable System
Creators: name: Borot, Gaëtan
name: Eynard, Bertrand
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 14H70, 14H42, 30Fxx

description: We propose a definition for a Tau function and a spinor kernel (closely related to Baker-Akhiezer functions), where times parametrize slow (of order 1/N) deformations of an algebraic plane curve. This definition consists of a formal asymptotic series in powers of 1/N, where the coefficients involve theta functions whose phase is linear in N and therefore features generically fast oscillations when N is large. The large N limit of this construction coincides with the algebro-geometric solutions of the multi-KP equation, but where the underlying algebraic curve evolves according to Whitham equations. We check that our conjectural Tau function satisfies Hirota equations to the first two orders, and we conjecture that they hold to all orders. The Hirota equations are equivalent to a self-replication property for the spinor kernel. We analyze its consequences, namely the possibility of reconstructing order by order in 1/N an isomonodromic problem given by a Lax pair, and the relation between "correlators", the tau function and the spinor kernel. This construction is one more step towards a unified framework relating integrable hierarchies, topological recursion and enumerative geometry.
Mikroemulsionen als moderne Formulierungen zum Einsatz bei chronisch entzündlichen Hauterkrankungen am Beispiel Tacrolimus und Linolsäure
Creators: name: Göbel, Alexandra Sabine Bärbel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2010
Subjects: subject: Pharmakologie
subject: Endogenes Ekzem
subject: Mikroemulsion
subject: Tacrolimus
subject: Linolsäure
subject: Online-Publikation
subject: Hochschulschrift
subject: 615.19
subject: 615

description: Das Ziel dieser Arbeit bestand darin, großmolekulare, lipophile Substanzen (Tacrolimus und Linolsäure) in Mikroemulsionen zu inkorporieren und damit in großem Maße in die Haut zu transportieren, um eine erhöhte Bioverfügbarkeit am Zielort in der Haut zu erreichen. Es konnten insgesamt vier verschiedene Mikroemulsionssysteme für die Inkorporierung von Tacrolimus und Linolsäure entwickelt werden. Die Charakterisierung der Systeme ergab für alle Mikroemulsionen keine Hinweise auf ein irritatives Potential im Sinne des HET CAM. Des Weiteren konnten mittels verschiedener physikochemischer Charakterisierungsmethoden eindeutig isotrope Systeme mit einer tröpfchenartigen, kolloidalen Phase oder aber bikontinuierlichen Charakter identifiziert werden. Die Penetrationsuntersuchungen ex vivo ergaben für alle vier getesteten Systeme eine schnelle Penetration von Tacrolimus bzw. Linolsäure in die Haut. Im Vergleich zu den jeweiligen Standardvehikeln konnte von allen Mikroemulsionen eine schnelle und signifikant höhere Penetration von Tacrolimus bzw. Linolsäure in die jeweiligen Zielkompartimente erreicht werden. Es wurden drei- bis fünffach höhere bioverfügbare Konzentrationen ermittelt. Es wurde gezeigt, dass durch den Einsatz von kolloidalen Carriern die Penetration und Bioverfügbarkeit von Tacrolimus und Linolsäure essentiell verbessert werden konnte.
Biomarker in experimentellen Modellen der pulmonalen Hypertonie
Creators: name: Grupe, Julia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2011
Subjects: subject: Pulmonale Hypertonie
subject: Diagnosesystem
subject: Biomarker
subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Die pulmonalarterielle Hypertonie (PAH) ist eine lebensbedrohliche Erkrankung, die in der Regel erst spät diagnostiziert wird, was zu einer schlechten Prognose führt. Forschungsbedarf liegt demnach in der Etablierung von Biomarkern zur Unterstützung einer frühen Diagnose und Evaluation des Schweregrades der Erkrankung. Die Untersuchung neuer und etablierter Biomarker in einem Standardtiermodell der PAH (Monocrotalin-Modell) in Abgrenzung zu einem Tiermodell für isolierte rechtsventrikuläre Druckbelastung (Pulmonalarterielles Banding-Modell) ergab, dass die Remodeling-Marker Matrix Metalloproteinase-2 (MMP-2), Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) und Osteopontin (OPN) im Plasma zur Darstellung charakteristischer Remodeling-Prozesse der PAH auf der Grundlage der untersuchten Modelle nicht geeignet sind. Die Untersuchung der druck-/dehnungssensitiven Marker Atriales Natriuretisches Peptid (ANP) und B-Typ natriuretisches Peptid (BNP) im Plasma ebenso wie die nicht-invasiven echokardiographischen Parameter pulmonalarterielle Flussgeschwindigkeit (PAF) und pulmonalarterielle Akzelerationszeit (PAAT) ergab hingegen, dass diese valide Marker zur Darstellung von rechtsventrikulärer Druckbelastung sind. ANP und BNP im Plasma sowie die echokardiographischen Parameter sind darüber hinaus zum Nachweis des Ansprechens auf eine Therapie geeignet.
Improving three-dimensional mass mapping with weak gravitational lensing using galaxy clustering
Creators: name: Simon, Patrick
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The weak gravitational lensing distortion of distant galaxy images (defined as sources) probes the projected large-scale matter distribution in the Universe. To improve quality in the 3D mass mapping using 3D-lensing, we combine the lensing information with the spatial clustering of a population of galaxies that trace the matter density with a known galaxy bias (defined as tracers). For our minimum variance estimator, merely all the second-order bias of the tracers has to be known, which can in principle be self-consistently constrained in the data by lensing techniques. This synergy introduces a new noise component because of the stochasticity in the matter-tracer density relation. We give a description of the stochasticity noise in the Gaussian regime, and we investigate the estimator characteristics analytically. We apply the estimator to a mock survey based on the Millennium Simulation. The estimator linearly mixes the individual lensing mass and tracer number density maps into a combined smoothed mass map. The weighting in the mix depends on the S/N of the individual maps and the correlation, $r$, between the matter and galaxy density. The weight of the tracers can be reduced by hand. For moderate mixing, the S/N in the mass map improves by a factor $\sim2-3$ for $r\gtrsim0.4$; the systematic offset between a true and apparent mass peak distance ($z$-shift bias) in a lensing-only map is eliminated, even for weak correlations of $r\sim0.4$. If the second-order bias of tracer galaxies can be determined, the synergy technique potentially provides an option to improve redshift accuracy and completeness of the lensing 3D mass map. However,the estimator's performance on sub-degree, non-Gaussian scales depends on all details in the galaxy bias mechanism and, hence, its accuracy on the choice of the tracer population.[abridged]
description: 15 pages, 8 figures, language corrections, A&A in press
Double-path dark-state laser cooling in a three-level system
Creators: name: Cerrillo, Javier
name: Retzker, Alex
name: Plenio, Martin B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a detailed analysis of a robust and fast laser cooling scheme [J. Cerrillo et al.,Phys. Rev. Lett. 104, 043003 (2010)] on a three-level system. A special laser configuration, applicable to trapped ions, atoms, or cantilevers, designs a double-path quantum interference that eliminates the blue sideband in addition to the carrier transition, thus excluding any heating process involving up to one-phonon interactions. As a consequence, cooling achieves vanishing phonon occupation up to first order in the Lamb-Dicke parameter expansion. Underlying this scheme is a combined action of two cooling schemes which makes the proposal very flexible under constraints of the physical parameters such as laser intensity, detuning, or optical access, making it a viable candidate for experimental implementation. Furthermore, it is considerably faster than existing ground state cooling schemes. Its suitability as a cooling scheme for several ions in a trap and three-dimensional cooling is shown.
description: 10 pages, 8 figures
A Novel Ventilator Design for COVID-19 and Resource-Limited Settings
Creators: name: Madekurozwa, Michael
name: Bonneuil, Willy V.
name: Frattolin, Jennifer
name: Watson, Daniel J.
name: Moore, Axel C.
name: Stevens, Molly
M.
name: E. Moore Jr., James
name: Mathiszig-Lee, Jakob
name: Batenburg-Sherwood, Joseph van
Publisher: name: figshare
Year: 2021
Subjects: subject: 90304 Medical Devices
subject: FOS: Medical engineering

description: Data processed and presented in the published paper Frontiers published paper (doi: 10.3389/fmedt.2021.707826).
Wirksamkeit verschiedener targeted drugs in Keimzelltumorzelllinien mit unterschiedlichem Differenzierungsgrad und differenzieller Cisplatinsensitivität
Creators: name: Schaffrath, Judith
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2016
Subjects: subject: 611

description: Das Ziel der Arbeit war es, die Wirksamkeit verschiedener targeted drugs in testikulären Keimzelltumorzelllinien mit unterschiedlicher Cisplatinsensitivität zu untersuchen. Die in vitro Aktivität der Kinaseinhibitoren RAD001, AEE788 und AEW541 wurde in Cisplatin-sensitiven und -resistenten Keimzelltumorzelllinien untersucht. Dabei zeigten die Substanzen in allen Zelllinien zytotoxische Aktivität unabhängig von der Cisplatinsensitivität, die Kombination aus Cisplatin und den Kinaseinhibitoren zeigte additive und antagonistische Effekte. Zur Evaluation der Aktivität der Kinaseinhibitoren wurde die Expression und Phosphorylierung der Zielproteine vor und nach Exposition gegenüber den Substanzen im Western Blot untersucht. Während die Zelllinien Unterschiede in Expression und Phosphorylierung der untersuchten Proteine zeigten, konnte keine Korrelation zwischen Proteinexpression und -phosphorylierung und der Wirksamkeit der Kinaseinhibitoren nachgewiesen werden.
description: The aim of this study was to analyze the efficacy of targeted drugs in testicular germ cell cancer (GCT) cell lines with differential cisplatin sensitivity. The in vitro activity of kinase inhibitors RAD001, AEE788 and AEW541 was investigated in cisplatin sensitive and resistant GCT cell lines. The agents significantly inhibited proliferation in both cisplatin sensitive and resistant cell lines. The combination of cisplatin and the kinase inhibitors showed both additive and antagonistic effects in the studied cell lines. To evaluate the activity of the kinase inhibitors, western blot analysis of both the targeted receptors and their phosphorylated state was performed both before and after exposure to each substance. While the examined cell lines showed different expression profiles of the targeted receptors, there was no correlation between their expression and phosphorylation and the effectiveness of the agents.
Präklinische Validierung barriereprotektiver Effekte eines Niacinamid-haltigen Kosmetikums
Creators: name: Kreft, Daniela Christine
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2016
Subjects: subject: 615

description: Niacinamid ist ein Vitamin B, kommt natürlich vor und ist als Bestandteil der Coenzyme NAD und NADP auch in der Haut vorhanden. Es wurde als einer der Induktoren der keratinozytären Lipid- und Ceramidsynthese identifiziert. Durch Induktion der Aktivität der Serinpalmitoyltransferase (SPT), dem Schrittmacherenzym des Sphingolipidsyntheseweges, sowie der Synthese freier Fettsäuren und des Cholesterols wird ein komplexer Einfluss auf die Quantität der Bestandteile des Stratum corneum vermittelt. Die praktische Relevanz dieser biochemischen Wirkungen auf die Barrierefunktionalität des Stratum corneum wurde bereits belegt und Wirkeffekte auf atopischer Haut nachgewiesen. Die topische Anwendung von Niacinamid wird in kosmetischen Präparaten bereits seit längerer Zeit praktiziert. Meistens liegen zu den eingesetzten Präparaten aber keine galenischen Untersuchungen vor, die das Penetrationsprofil des Wirkstoffes belegen und die kutane Bioverfügbarkeit nachweisen.
description: Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. It is part of the pyridine nucleotides nicotinamide-adenine dinucleotide (NAD) and nicotinamide-adenine dinucleotide phosphate (NADP) in human skin. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has multiple positive effects on human skin depending on its concentration. Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects, especially on dry skin.
Architecture of Kepler's Multi-transiting Systems: II. New investigations with twice as many candidates
Creators: name: Fabrycky, Daniel C.
name: Lissauer, Jack J.
name: Ragozzine, Darin
name: Rowe, Jason F.
name: Steffen, Jason H.
name: Agol, Eric
name: Barclay, Thomas
name: Batalha, Natalie
name: Borucki, William
name: Ciardi, David R.
name: Ford, Eric B.
name: Geary, John C.
name: Holman, Matthew J.
name: Jenkins, Jon M.
name: Li, Jie
name: Morehead, Robert C.
name: Shporer, Avi
name: Smith, Jeffrey C.
name: Still, Martin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report on the orbital architectures of Kepler systems having multiple planet candidates identified in the analysis of data from the first six quarters of Kepler data and reported by Batalha et al. (2013). These data show 899 transiting planet candidates in 365 multiple-planet systems and provide a powerful means to study the statistical properties of planetary systems. Using a generic mass-radius relationship, we find that only two pairs of planets in these candidate systems (out of 761 pairs total) appear to be on Hill-unstable orbits, indicating ~96% of the candidate planetary systems are correctly interpreted as true systems. We find that planet pairs show little statistical preference to be near mean-motion resonances. We identify an asymmetry in the distribution of period ratios near first-order resonances (e.g., 2:1, 3:2), with an excess of planet pairs lying wide of resonance and relatively few lying narrow of resonance. Finally, based upon the transit duration ratios of adjacent planets in each system, we find that the interior planet tends to have a smaller transit impact parameter than the exterior planet does. This finding suggests that the mode of the mutual inclinations of planetary orbital planes is in the range 1.0-2.2 degrees, for the packed systems of small planets probed by these observations.
description: Accepted to ApJ
VLBI search for the radio counterpart of HESS J1943+213
Creators: name: Gabanyi, K. E.
name: Dubner, G.
name: Giacani, E.
name: Paragi, Z.
name: Frey, S.
name: Pidopryhora, Y.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: HESS J1943+213, a TeV point source close to the Galactic plane recently discovered by the H.E.S.S. collaboration, was proposed to be an extreme BL Lacertae object, though a pulsar wind nebula (PWN) nature could not be completely discarded. To investigate its nature, we performed high-resolution radio observations with the European Very Long Baseline Interferometry Network (EVN) and reanalyzed archival continuum and H {\sc i} data. The EVN observations revealed a compact radio counterpart of the TeV source. The low brightness temperature and the resolved nature of the radio source are indications against the beamed BL Lacertae hypothesis. The radio/X-ray source appears immersed in a $\sim$ 1\arcmin elliptical feature suggesting a possible galactic origin (PWN nature) for the HESS source. We found that HESS\,J1943+213 is located in the interior of a $\sim1\degr$ diameter H {\sc i} feature, and explored the possibility of they being physically related.
description: Significantly revised and extended. Accepted for publication in ApJ (ApJ, 762, 63). (4 figures.)
Neosynthese und Derivatisierung mariner Glycoglycerolipide als potentielle Inhibitoren der Myt1 Kinase
Creators: name: Göllner, Christiane
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Die humane Myt1 Kinase ist ein wichtiger Regulator am G2/M-Übergang im Zellzyklus. In einem systematischen Screening verschiedener Naturstoffe hinsichtlich ihrer antitumoralen Wirkung zeigte ein Algenextrakt aus einer taxonomisch unbekannten, marinen Alge biologische Aktivität gegenüber der Myt1 Kinase. Die Isolation der bioaktiven Substanzen lieferte zwei wirksame Glycoglycerolipide mit IC50-Werten zwischen 0,12 bis 0,43 μg/ml. Eine der Substanzen, das potentere 1,2-Dipalmitoyl-3-(N-palmitoyl-6´-amino-6´-deoxy-α-D-glucosyl)-sn-glycerol wurde als Leitstruktur für nachfolgende Strukturmodifikationen ausgewählt. Im Rahmen dieser Arbeit wurde ein Synthesekonzept für die Darstellung des nativen Glycoglycerolipids ausgearbeitet. Die mehrstufige Synthese erforderte eine geeignete Schutzgruppenstrategie zur selektiven Einführung von Molekülen. Unter retrosynthetischen Gesichtspunkten wurde die Synthese in drei wichtige Abschnitte untergliedert. Der erste Abschnitt erforderte die Darstellung eines partiell geschützten 6-Glucosaminderivats, der zweite Schritt umfasste das Glycosylierungsverfahren unter stereochemischer Kontrolle. Im dritten Teil erfolgte die Einführung der Fettsäurereste zum Glycoglycerolipid. Die erarbeitete Strategie erlaubte die selektive Modifikation definierter Strukturen im Molekül, mit dem Ziel innerhalb des Moleküls die Substitutionen des Kohlenhydratbausteins, der Kettenlänge und die Darstellung der Anomeren vorzunehmen. Die synthetisierten Endverbindungen wurden im TR-FRET Kinasebindungsassay vermessen.
Stochastic models and Monte Carlo algorithms for Boltzmann type equations
Creators: name: Wagner, Wolfgang
Publisher: name: Weierstrass Institute
Year: 2003
Subjects: subject: Boltzmann equation
subject: stochastic models
subject: Monte Carlo algorithms
subject: 65C05
subject: 76P05
subject: 82C80

description: In this paper we are concerned with three typical aspects of the Monte Carlo approach. First there is a certain field of application, namely physical systems described by the Boltzmann equation. Then some class of stochastic models is introduced and its relation to the equation is studied using probability theory. Finally Monte Carlo algorithms based on those models are constructed. Here numerical issues like efficiency and error estimates are taken into account. In Section 1 we recall some basic facts from the kinetic theory of gases, introduce the Boltzmann equation and discuss some applications. Section 2 is devoted to the study of stochastic particle systems related to the Boltzmann equation. The main interest is in the convergence of the system (when the number of particles increases) to the solution of the equation in an appropriate sense. In Section 3 we introduce a modification of the standard "direct simulation Monte Carlo" method, which allows us to tackle the problem of variance reduction. Results of some numerical experiments are presented.
Predictors for discrete time processes with energy decay on higher frequencies
Creators: name: Dokuchaev, Nikolai
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optimization and Control (math.OC)
subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 42A38, 93E10, 62M15, 42B30

description: The predictability of discrete-time processes is studied in a deterministic setting. A family of one-step-ahead predictors is suggested for processes of which the energy decays at higher frequencies. For such processes, the prediction error can be made arbitrarily small. The predictions can be robust with respect to the noise contamination at higher frequencies.
description: 5 pages
Stability of the Greedy Algorithm on the Circle
Creators: name: Rolla, Leonardo T.
name: Sidoravicius, Vladas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider a single-server system with service stations in each point of the circle. Customers arrive after exponential times at uniformly-distributed locations. The server moves at finite speed and adopts a greedy routing mechanism. It was conjectured by Coffman and Gilbert in~1987 that the service rate exceeding the arrival rate is a sufficient condition for the system to be positive recurrent, for any value of the speed. In this paper we show that the conjecture holds true.
Laparoskopische radikale Tumornephrektomie versus offene transperitoneale Tumornephrektomie - Beurteilung des klinischen Verlaufes und des Ausmaßes der Gewebstraumatisierung mit biochemischen und immunologischen Parametern
Creators: name: Volk, Inga
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2011
Subjects: subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Einleitung: In den letzten Jahren hat die laparoskopische Tumornephrektomie an Bedeutung gewonnen. Ziel der Arbeit ist ein Vergleich zwischen offener und laparoskopischer Tumornephrektomie bezüglich der immunologischen Parameter. Material und Methoden: Zwischen 04/2003 und 02/2007 wurden 52 Personen ohne Randomisierung in die Untersuchung eingeschlossen. Die Blutentnahmen zur Bestimmung von Il-6, Il-10, CRP und SAA erfolgten nach definiertem Protokoll. Weiterhin wurden Operationsdauer und postoperative Hospitalisationszeit ermittelt. Resultate: Bei der laparoskopischen Gruppe zeigten sich postoperativ signifikant niedrigere IL-6 und CRP-Werte, für SAA und IL-10 existieren keine signifikanten Unterschiede zur offenen Gruppe. Die durchschnittliche OP-Dauer betrug laparoskopisch 167 Minuten vs. 132 Minuten bei offener Operation. Die mittlere postoperative Krankenhausverweildauer ergab 6 Tage in der laparoskopischen und 10 Tage in der offenen Gruppe. Diskussion: Mit signifikant niedrigeren postoperativen Werten von CRP und IL-6 in der laparoskopischen Gruppe kann die Minimalinvasivität gezeigt werden. IL-10 und SAA stellten sich als ungeeignete Marker zum Nachweis der Minimalinvasivität dar.