cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Shifts in flood generation processes exacerbate regional flood anomalies in Europe
Creators: name: Tarasova, Larisa
name: Lun, David
name: Merz, Ralf
name: Blöschl, Günter
name: Basso, Stefano
name: Bertola, Miriam
name: Miniussi, Arianna
name: Rakovec, Oldrich
name: Samaniego, Luis
name: Thober, Stephan
name: Kumar, Rohini
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 550

description: Anomalies in the frequency of river floods, i.e., flood-rich or -poor periods, cause biases in flood risk estimates and thus make climate adaptation measures less efficient. While observations have recently confirmed the presence of flood anomalies in Europe, their exact causes are not clear. Here we analyse streamflow and climate observations during 1960-2010 to show that shifts in flood generation processes contribute more to the occurrence of regional flood anomalies than changes in extreme rainfall. A shift from rain on dry soil to rain on wet soil events by 5% increased the frequency of flood-rich periods in the Atlantic region, and an opposite shift in the Mediterranean region increased the frequency of flood-poor periods, but will likely make singular extreme floods occur more often. Flood anomalies driven by changing flood generation processes in Europe may further intensify in a warming climate and should be considered in flood estimation and management.
A Wide Band Receiver Module
Creators: name: Isacsson, Magnus
name: Johansson, Stefan
name: Ståhl, Johan
name: Thiesies, Heiko
name: Lingsten, Johan
name: Tengs, Audun
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: This paper presents the design and measured
results of a highly integrated Multi-Chip-Module (MCM)
developed for a wide band Electronic Support Measure
ESM) application. The MCM is based on Low Temperature
Co-fired Ceramic (LTCC) technology and the main
functionality is implemented in several wide band
multifunction MMICs. By using an all-level design
approach, the MMICs and the MCM showed full
performance after the first design iteration. Simulations and
measured results show excellent agreement.
Corporate Governance in Determining the Stock Price in Colombo Stock Exchange
Creators: name: Dissabandara, Hareedra
name: Fernando, PKCL
Publisher: name: figshare
Year: 2021
Subjects: subject: 150303 Corporate Governance and Stakeholder Engagement
subject: FOS: Economics and business

description: A sample of 64 companies was chosen as representative of the population out of 296 companies listed on the Colombo Stock Exchange (CSE), excluding banking and finance sector and data was collected using secondary method. Compliance level of corporate governance have been measured by utilizing self-constructed Corporate Governance Index (CG Index) with five sub-indexes namely Board Structure (BS), CEO and Management(CEO), Transparency and Disclosure (TR), Investor Relation(IV) and CSR Disclosure(CSR). The index contains 40 criteria under the above Sub-Indexes. The study found that there is no significant relationship between overall CG index and the share price. However, transparency demonstrated a significant negative impact on the share price.
The evidence base of US Food and Drug Administration approvals of novel cancer therapies from 2000 to 2020
Creators: name: Gloy, Viktoria
name: Schmitt, Andreas Michael
name: Düblin, Pascal
name: Hirt, Julian
name: Axfors, Cathrine
name: Kuk, Hanna
name: Pereira, Tiago V.
name: Locher, Clara
name: Caquelin, Laura
name: Walter-Claudi, Martin
name: Lythgoe, Mark P.
name: Herbrand, Amanda
name: Kassenda, Benjamin
name: Hemkens, Lars Gerrit
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 615

description: Concerns have been raised that regulatory programs to accelerate approval of cancer drugs in cancer may increase uncertainty about benefits and harms for survival and quality of life (QoL). We analyzed all pivotal clinical trials and all non-pivotal randomized controlled trials (RCTs) for all cancer drugs approved for the first time by the FDA between 2000 and 2020. We report regulatory and trial characteristics. Effects on overall survival (OS), progression-free survival and tumor response were summarized in meta-analyses. Effects on QoL were qualitatively summarized. Between 2000 and 2020, the FDA approved 145 novel cancer drugs for 156 indications based on 190 clinical trials. Half of indications (49%) were approved without RCT evidence; 82% had a single clinical trial only. OS was primary endpoint in 14% of trials and QoL data were available from 25%. The median OS benefit was 2.55 months (IQR, 1.33-4.28) with a mean hazard ratio for OS of 0.75 (95%CI, 0.72-0.79, I2 = 42). Improvement for QoL was reported for 7 (4%) of 156 indications. Over time, priority review was used increasingly and the mean number of trials per indication decreased from 1.45 to 1.12. More trials reported results on QoL (19% in 2000-2005; 41% in 2016-2020). For 21 years, novel cancer drugs have typically been approved based on one single, often uncontrolled, clinical trial, measuring surrogate endpoints. This leaves cancer patients without solid evidence that novel drugs improve their survival or QoL and there is no indication towards improvement.
Additional file 1 of Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma
Creators: name: Zhang, Ting
name: Shi, Wang
name: Tian, Ke
name: Kong, Yushan
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1: Table S1. Factors related to LYN metastasis
Thermalization and entanglement following a non-relativistic holographic quench
Creators: name: Keranen, Ville
name: Keski-Vakkuri, Esko
name: Thorlacius, Larus
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We develop a holographic model for thermalization following a quench near a quantum critical point with non-trivial dynamical critical exponent. The anti-de Sitter Vaidya null collapse geometry is generalized to asymptotically Lifshitz spacetime. Non-local observables such as two-point functions and entanglement entropy in this background then provide information about the length and time scales relevant to thermalization. The propagation of thermalization exhibits similar "horizon" behavior as has been seen previously in the conformal case and we give a heuristic argument for why it also appears here. Finally, analytic upper bounds are obtained for the thermalization rates of the non-local observables.
description: 33 pages, 11 figures. v2: minor typos corrected, references added, a new section added in the appendix, published version
Linearized Switching Amplifier
Creators: name: Mahmoudi, R.
name: Milosevic, D.
name: Van Der Tang, J.D.
name: Hegt, J. A.
name: Van Roermund, A. H. M.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: Two different concepts for high efficiency
linear amplification of variable envelope RF signals are
presented. The EER concept is based on a Class-E PA, and
it has been demonstrated that excellent ACPR performance
can be achieved. The Class-E PA employs a GaAs HBT
device and the simulated PAE is higher than 70% at 2 GHz.
The wideband linearization feature of the “Limit Duty
Cycle Modulation” technique, in conjunction with the
applicability of the switching type amplifiers enables the
realization of a new kind of transmitter architecture that
facilitates the optimization of linearity and power-efficiency.
A suitable limit duty cycle configuration for broadband
communication applications is introduced and considered in
some depth.
Place of residence does matter for educational integration : the relevance of spatial contexts for refugees’ transition to VET in Germany
Creators: name: Meyer, Franziska
name: Winkler, Oliver
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 379

description: For the mostly young refugees who arrived in Germany around 2015/2016, completing vocational education and training (VET) represents the most promising opportunity for professional and social integration. However, access opportunities to VET are characterized by spatial inequalities: German districts vary considerably according to labour market structure, economic productivity and demographic development, which constitute the supply and demand for training places in the dual VET sector, to which refugees predominantly have access. This paper examines if the transition chances of young refugees aged 18–30 to VET depend on their place of residence. For this, we analysed the IAB-BAMF-SOEP Survey of Refugees (n = 5216) using multi-level discrete-time event history analysis. On the supply side, higher economic productivity (measured by GDP), a low unemployment rate and a greater number of small versus large businesses in the district are positively associated with refugees’ transition chances. On the demand side, an increasing number of school leavers with no school-leaving certificate and of refugees in the district are negatively associated with the respective chances. Our results suggest that spatial characteristics essentially matter for young refugees’ training opportunities and thus support recommendations to reform current distribution policies, in which central spatial contextual factors remain largely disregarded.
GaN Technology Overview: Accomplishments
and Challenges
Creators: name: Saunier, Paul
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: This paper reports the (published) status
of the AlGaN/GaN technology in the United States.
Activities can be divided between AlGaN/GaN on
SiC substrates for military applications, sponsored
by DoD and AlGaN/GaN on Si for Base Stations.
No doubt that early emphasis for US DoD has been
“performances” (the W/mm race!) and progress
has been fast, probably culminating with UCSB
and Cree demonstrating 32W/mm at 4 GHz. These
excellent performances have been made possible by
the introduction and refinement of the “Field-
Plate”. Understandably, the emphasis is now
reliability, and all the challenges have not been
conquered. In the commercial world, Nitronex has
been pionneering AlGaN/GaN on Si,
manufacturing large gate width devices using
MOCVD grown 4” Si substrates; 20W at –39dBc is
achieved with 11.5dB gain and 25% pae (28V bias)
over 1.8-2.2GHz. Excellent reliability is extracted
with over 20 years MTTF. TriQuint has
demonstrated the potential of GaN on Si for higher
frequencies with 7W/mm with 38% pae and 9dB
gain at 10GHz.
Model-Independent Bounds on a Light Higgs
Creators: name: Azatov, Aleksandr
name: Contino, Roberto
name: Galloway, Jamison
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present up-to-date constraints on a generic Higgs parameter space. An accurate assessment of these exclusions must take into account statistical, and potentially signal, fluctuations in the data currently taken at the LHC. For this, we have constructed a straightforward statistical method for making full use of the data that is publicly available. We show that, using the expected and observed exclusions which are quoted for each search channel, we can fully reconstruct likelihood profiles under very reasonable and simple assumptions. Even working with this somewhat limited information, we show that our method is sufficiently accurate to warrant its study and advocate its use over more naive prescriptions. Using this method, we can begin to narrow in on the remaining viable parameter space for a Higgs-like scalar state, and to ascertain the nature of any hints of new physics---Higgs or otherwise---appearing in the data.
description: 32 pages, 10 figures; v3: correction made to basis of four-derivative operators in the effective Lagrangian, references added
Recent Developments and Trends in GaN HFETs
Creators: name: Théron, D.
name: Gaquière, C.
name: De Jaeger, J.C.
name: Delage, S. L.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: This paper reviews the main challenges and
results concerning GaN HFET research and development in
Europe. Today several actors are working to allow the
emergence of an European source for this technology. The
activity sweeps all R&D fields from material growth to
circuit realization and reliability.
GaN THz Electronics
Creators: name: Pavlidis, Dimitris
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: The use of GaN in THz electronic
applications is discussed. The devices addressed include
Negative Differential Resistance (NDR), Superlattice diodes
and Plasma Wave devices. Fundamental considerations of
the transport properties are made to explore the high
frequency potential of this material system. The use of new
concepts for GaN THz electronics is also addressed.
Matching details of alpha-DG glycosylating enzymes within metazoa. from High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan
Creators: name: Bigotti, Maria Giulia
name: Brancaccio, Andrea
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Structural Biology

description: Best representative scores found by comparing human sequences with those of different animal groups for each of the thirteen enzymes under analysis.
SiC and GaN Based Transistor and Circuit Advances
Creators: name: Palmour, J.W.
name: Milligan, J.W.
name: Henning, J.
name: Allen, S.T.
name: Ward, A.
name: Parikh, P.
name: Smith, R.P.
name: Saxler, A.
name: Moore, M.
name: Wu, Y.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: Significant progress has been made in the
development of SiC MESFETs and MMIC power
amplifiers manufactured on 3-inch high purity semiinsulating
(HPSI) 4H-SiC substrates. Wide bandwidth
circuits using both 10 Watt and 60 watt MESFETs are
presented. These MESFETs show no degradation after
RFHTOL at a baseplate of 90°C for 4000 hours. High
power SiC MMIC amplifiers are shown with excellent yield
and repeatability using a released foundry process. GaN
HEMTs on HPSI SiC are reported with >30 W/mm RF
output power density, and 10 GHz PAE of 72% is also
demonstrated for lower voltage devices. Finally, a GaN
HEMT operating life of over 500 hours at a TJ =160°C is
also reported.
Macroptilium prostratum Urb.
Creators: name: Araújo, Diogo
name: Alves, Marccus
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Macroptilium
Macroptilium prostratum

description: 57. Macroptilium prostratum (Benth.) Urb.
Brazil (Pernambuco, Rio Grande do Sul), Paraguay, Argentina.
Selected Voucher:—Macacos, Araújo et al. 438 (UFP).
description: Published as part of Araújo, Diogo & Alves, Marccus, 2010, Climbing plants of a fragmented area of lowland Atlantic Forest, Igarassu, Pernambuco (northeastern Brazil), pp. 1-24 in Phytotaxa 8 on page 19, DOI: 10.11646/phytotaxa.8.1.1, http://zenodo.org/record/4893863
Intersective polynomials and Hensel's Lemma
Creators: name: Hyde, Andrea
Publisher: name: University of British Columbia
Year: 2014

description: An intersective polynomial is a polynomial with integer coefficients that has no rational roots, but has a root modulo every integer greater than 1. These polynomials have been difficult to find using traditional methods. In this thesis, we employ elementary methods, namely Hensel’s Lemma and the Chinese remainder theorem, to allow us to create three new infinite families of intersective polynomials. In order to create a candidate intersective polynomial, we employ methods from Galois theory. We multiply together carefully chosen polynomials that define subfields of a splitting field to create our candidate. We chose the subfields by first finding the n-cover, a collection of n proper subgroups, of the Galois group and identifying the corresponding subfields. We multiply the minimal polynomials of the subfields of the chosen splitting fields together to create the candidate intersective polynomial. From our method of creating candidates we can see that intersective polynomials have at least two irreducible factors. In order to prove that these polynomials have a root modulo every integer greater than 1, we examine each factor modulo certain prime numbers and determine which sets of primes admit solutions for each factor. We then use Hensel’s Lemma to lift those solutions to infinitely high powers of the particular primes. Finally, we combine the solutions modulo prime powers by using the Chinese remainder theorem to show that the polynomial has solutions modulo every integer greater than 1. Through the method outlined above, we have created three infinite families of intersective polynomials: (x³ − n)(x² + 3) when the prime factors of n are of the form 3k + 1 and n is congruent to 1 mod 9; (x² − a)(x² − b)(x² − a₁b₁) when at least one of a, b, a₁b₁ is congruent to 1 modulo 8 and one of the Legendre Symbols (a/p), (b/p), (a₁b₁/p) has the value +1; and (x^q −n)(x^(q-¹) +x^q-²+...+ x + 1) when the prime factors of n are kq + 1 and n is congruent to 1 modulo q² for an odd prime q. In the last chapter, we treat some special cases of intersective polynomials which will be considered in detail in future work.
Glycation Interferes with the Activity of the Bi-Functional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetyl-mannosamine Kinase (GNE)
Creators: name: Hagenhaus, Vanessa
name: Gorenflos López, Jacob L.
name: Rosenstengel, Rebecca
name: Neu, Carolin
name: Hackenberger, Christian P. R.
name: Celik, Arif
name: Weinert, Klara
name: Nguyen, Mai-Binh
name: Bork, Kaya
name: Horstkorte, Rüdiger
name: Gesper, Astrid
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Mutations in the gene coding for the bi-functional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of the sialic acid biosynthesis, are responsible for autosomal-recessive GNE myopathy (GNEM). GNEM is an adult-onset disease with a yet unknown exact pathophysiology. Since the protein appears to work adequately for a certain period of time even though the mutation is already present, other effects appear to influence the onset and progression of the disease. In this study, we want to investigate whether the late onset of GNEM is based on an age-related effect, e.g., the accumulation of post-translational modifications (PTMs). Furthermore, we also want to investigate what effect on the enzyme activity such an accumulation would have. We will particularly focus on glycation, which is a PTM through non-enzymatic reactions between the carbonyl groups (e.g., of methylglyoxal (MGO) or glyoxal (GO)) with amino groups of proteins or other biomolecules. It is already known that the levels of both MGO and GO increase with age. For our investigations, we express each domain of the GNE separately, treat them with one of the glycation agents, and determine their activity. We demonstrate that the enzymatic activity of the N-acetylmannosamine kinase (GNE-kinase domain) decreases dramatically after glycation with MGO or GO—with a remaining activity of 13% ± 5% (5 mM MGO) and 22% ± 4% (5 mM GO). Whereas the activity of the UDP-N-acetylglucosamine 2-epimerase (GNE-epimerase domain) is only slightly reduced after glycation—with a remaining activity of 60% ± 8% (5 mM MGO) and 63% ± 5% (5 mM GO).
Diamond for High Power / High Temperature Electronics
Creators: name: Kohn, E.
name: Kubovic, M.
name: Hernandez-Guillen, F.
name: Denisenko, A.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2004
Subjects: ING-INF/01 Elettronica

description: Diamond is a wide bandgap semiconductor with
extremely attractive properties but also many technological
difficulties. Doping is restricted to deep impurities and
substrate size is very limited. Nevertheless in proof of concept
experiments, the potential for high power, high temperature
and high frequency applications can already well be
estimated. In addition, first passive MEMS elements for
advanced circuit applications have also been demonstrated,
however still on nano-crystalline material, which is available
with large surface area. Thus it is already possible to discuss
an integrated systems approach when single crystal
substrates in wafer size become available.
Geometric Sobolev-like embedding using high-dimensional Menger-like curvature
Creators: name: Kolasiński, Sławomir
Publisher: name: arXiv
Year: 2012
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 28A75, 49Q10, 49Q20, 49Q15

description: We study a modified version of Lerman-Whitehouse Menger-like curvature defined for m+2 points in an n-dimensional Euclidean space. For 1 <= l <= m+2 and an m-dimensional subset S of R^n we also introduce global versions of this discrete curvature, by taking supremum with respect to m+2-l points on S. We then define geometric curvature energies by integrating one of the global Menger-like curvatures, raised to a certain power p, over all l-tuples of points on S. Next, we prove that if S is compact and m-Ahlfors regular and if p is greater than ml, then the P. Jones' β-numbers of S must decay as r^t with r \to 0 for some t in (0,1). If S is an immersed C^1 manifold or a bilipschitz image of such set then it follows that it is Reifenberg flat with vanishing constant, hence (by a theorem of David, Kenig and Toro) an embedded C^{1,t} manifold. We also define a wide class of other sets for which this assertion is true. After that, we bootstrap the exponent t to the optimal one a = 1 - ml/p showing an analogue of the Morrey-Sobolev embedding theorem. Moreover, we obtain a qualitative control over the local graph representations of S only in terms of the energy.
description: I removed Example 3.11, which was wrong in the sense that the \beta-numbers for this set do not decay as r^2
The n-ary Adding Machine and Soluble Groups
Creators: name: Rocha, Josimar da Silva
name: Sidki, Said Najati
Publisher: name: arXiv
Year: 2011
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F05, 20F16

description: We describe under a variety of conditions abelian subgroups of the automorphism group A of the regular n-ary tree T which are normalized by the n-ary adding machine t=(e,...,e,t)s where s is the n-cycle (0,1,...,n-1). As an application, for n a prime number, and for n = 4 we prove that every soluble subgroup of A containing t is an extension of a torsion-free metabelian group by a finite group.
description: 46 pages
Numerical and experimental investigation in the instability and the breakup of capillary water jet
Creators: name: Moallemi, Nima
Publisher: name: University of British Columbia
Year: 2014

description: In this thesis, the instability and breakup of free capillary jets are investigated. Both numerical and experimental methodologies are used to define the breakup process for capillary jets. High speed photography is used to capture droplet formation and to measure breakup length. In parallel, numerical simulations based on the volume of fluid (VOF) approach, with interface tracking and adaptive meshing are performed to provide further insight into the jet instabilities. The VOF method enables accurate tracking of the interface while reducing computational cost by means of adaptive grids. The growth rate of disturbance is compared with the theoretical prediction from a dispersion relation obtained by first-order perturbation analysis. Moreover, the numerical results show a good agreement with experimental data for the breakup length of the liquid jet under different wave numbers. The velocity profile and the pressure gradient in the necking zone of the jet are analyzed to clarify the droplet detachment process. In addition, Lagrangian analysis of fluid particles in the jet shows that when droplet detachment occurs, the direction of fluid particles changes dramatically due to droplet oscillations.
A new analytical, CAD-oriented model for the ohmic and radiation losses of asymmetric coplanar lines in hybrid and monolithic MIC's
Creators: name: Ghione, G.
name: Naldi, C.U.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1992
Subjects: ING-INF/01 Elettronica

description: The paper presents analytical approximations for the conductor, dielectric and radiation losses of asym­metric coplanar waveguides. The expression for the conductor losses is obtained through an extension of Owyang and Wu's conformal mapping approach [17]; the dielectric losses are estimated according to the so-called plane-wave approach [2]; finally, the analysis of radiation losses follows Rutledge's approach [19]. Comparisons with experimental results or numerical data derived from quasi-static or full-wave approaches are performed to validate the expressions presented.
Nobody can Really Afford Legal Services: The Price of Justice in Namibia
Creators: name: Zongwe, Dunia Prince
Publisher: name: Walter Sisulu University
Year: 2021
Subjects: subject: Law
subject: FOS: Law
subject: 180119 Law and Society

description: Nobody (except for the privileged few) can afford legal services in Namibia. In the light of this dawning awareness, how should the government and other stakeholders design the legal profession so that the greatest number of Namibians can access legal services and, ultimately, justice while preserving the profession's financial viability? The predominantly economic nature of this question means that its solutions lie less in the field of law than in the field of economics. Thus, this article adopts a methodology that reflects that insight. As a primary purpose, this article works towards solving the high cost of legal services in Namibia. It utilises a literature-review methodology that searches the scholarship on the legal profession for practical, down-to-earth solutions put forward in other countries to take the edge off the prohibitive cost of legal services. The article mainly finds that, if structured as a compulsory salary deduction, legal insurance promises the greatest positive impact on costs. And it concludes that the optimal solutions should consist of measures aimed at heightening competition in the legal profession and measures that broaden cost-sharing in providing legal assistance to the public. The article argues that competition can be effectively increased by lubricating the flow of information about prices and services, and by having more public entities bear the burden of expanding the system of legal assistance.
A T8.5 Brown Dwarf Member of the Xi Ursae Majoris System
Creators: name: Wright, Edward L.
name: Skrutskie, M. F.
name: Kirkpatrick, J. Davy
name: Gelino, Christopher R.
name: Griffith, Roger L.
name: Marsh, Kenneth A.
name: Jarrett, Tom
name: Nelson, M. J.
name: Borish, H. J.
name: Mace, Gregory
name: Mainzer, Amanda K.
name: Eisenhardt, Peter R.
name: McLean, Ian S.
name: Tobin, John J.
name: Cushing, Michael C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The Wide-field Infrared Survey Explorer has revealed a T8.5 brown dwarf (WISE J111838.70+312537.9) that exhibits common proper motion with a solar-neighborhood (8 pc) quadruple star system - Xi Ursae Majoris. The angular separation is 8.5 arc-min, and the projected physical separation is about 4000 AU. The sub-solar metallicity and low chromospheric activity of Xi UMa A argue that the system has an age of at least 2 Gyr. The infrared luminosity and color of the brown dwarf suggests the mass of this companion ranges between 14 and 38 Jupiter masses for system ages of 2 and 8 Gyr respectively.
description: AJ in press, 12 pages LaTeX with 6 figures. More astrometric data and a laser guide star adaptive optics image added
Porous polymeric microparticles foamed with supercritical CO2 as scattering white pigments
Creators: name: Borgmann, Luisa Maren
name: Johnsen, Siegbert
name: Santos De Oliveira, Cristine
name: Martins De Souza E Silva, Juliana
name: Li, Juan
name: Kirchlechner, Christoph
name: Gomard, Guillaume
name: Wiegand-Tripp, Gabriele
name: Hölscher, Hendrik
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 530

description: Nowadays, titanium dioxide (TiO2) is the most commercially relevant white pigment. Nonetheless, it is widely criticized due to its energy-intensive extraction and costly disposal of harmful by-products. Furthermore, recent studies discuss its potential harm for the environment and the human health. Environment-friendly strategies for the replacement of TiO2 as a white pigment can be inspired from nature. Here whiteness often originates from broadband light scattering air cavities embedded in materials with refractive indices much lower than that of TiO2. Such natural prototypes can be mimicked by introducing air-filled nano-scale cavities into commonly used polymers. Here, we demonstrate the foaming of initially transparent poly(methyl methacrylate) (PMMA) microspheres with non-toxic, inert, supercritical CO2. The properties of the foamed, white polymeric pigments with light scattering nano-pores are evaluated as possible replacement for TiO2 pigments. For that, the inner foam structure of the particles was imaged by phase-contrast x-ray nano-computed tomography (nano-CT), the optical properties were evaluated via spectroscopic measurements, and the mechanical stability was examined by micro compression experiments. Adding a diffusion barrier surrounding the PMMA particles during foaming allows to extend the foaming process towards smaller particles. Finally, we present a basic white paint prototype as exemplary application.
Technology independent nonlinear integral model of microwave electron devices
Creators: name: Filicori, Fabio
name: Monaco, Vito A.
name: Vannini, Giorgio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1992
Subjects: ING-INF/01 Elettronica

description: The paper describes a new technology-independent model for the large-signal performance prediction of electron devices. The Nonlinear Integral Model (NIM) is rigorously derived from the Volterra series through suitable modifications so that fast convergence can be achieved even under large-signal strongly nonlinear operation. In particular, the NIM, which can be directly used for Harmonic-Balance circuit analysis, enables the large-signal dynamic response of electron devices to be directly computed on the basis of data obtained either by conventional measurements or physics-based numerical simulations. This property makes the NIM particularly convenient for linking accurate device simulation based on carrier transport physics and Harmonic-Balance circuit analysis. Simulations and experimental results confirm the validity of the proposed modelling approach.
In vitro und in vivo Untersuchungen zur Wirksamkeit der Kombinationstherapie aus dem TIMP-1-GPI Fusionsprotein und Doxorubicin im HT1080-Fibrosarkom Modell
Creators: name: Augsburger, Daniela
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2018
Subjects: subject: Fibrosarkom
subject: Doxorubicin
subject: Tiermodell
subject: 616.994061

description: Das adulte Fibrosarkom ist ein hochmaligner Tumor mesenchymalen Ursprungs. Die oftmals schlechte Prognose liegt unter anderem in der hohen Rate therapieresistenter Tumorzellen begründet. Zur Verbesserung der Überlebenswahrscheinlichkeit, ist die Erforschung neuer, resistenzüberwindender Therapiestrategien unabdingbar. Die vorliegende Arbeit leistete einen Beitrag zur Resistenzforschung des adulten Fibrosarkoms. Der Fokus richtete sich hierbei auf das TIMP-1-GPI-Fusionsprotein, das hinsichtlich seines Einflusses auf die Sensitivität der Tumorzellen gegenüber Doxorubicin untersucht wurde. In vitro wurde die Wirkung der Kombinationstherapie auf die Zellproliferation, das klonogene Potential der Zellen und die Zellmigration beobachtet. Die Untersuchung der Wirksamkeit in vivo erfolgte an tumortragenden Balb/c Nacktmäusen. Die in vitro-Zytotoxizitäts- und Migrationsstudien ließen eine, die Chemosensitivität der Zellen wiederherstellende, Wirkung des Fusionsproteins erkennen. Diese Beobachtung konnte am neoadjuvanten Tiermodell bestätigt werden. Darüber zeigte sich in vitro ein therapeutischer Nutzen der Kombinationstherapie aus TIMP-1-GPI und Doxorubicin gegenüber TIMP-1-GPI-Monotherapie. Trotz neoadjuvanter Therapiekonzepte und großzügiger Tumorresektionen, kommt es in über 50% der Fälle zur Entstehung lokoregionaler Tumorrezidive. Dies legt die Entwicklung einer wirksamen Rezidivprophylaxe nahe. Im Rahmen dieser Arbeit wurde das TIMP-1-GPI-Fusionsprotein hinsichtlich der Eignung zur postoperativen Rezidivprophylaxe untersucht. Die Ergebnisse gaben erste Hinweise auf eine rezidivprophylaktische Wirkung des Fusionsproteins.
A CAD-oriented quasi-physical HEMT noise model for device design and optimization
Creators: name: Bonani, F.
name: Ghione, G.
name: Naldi, C.U.
name: Ponse, F.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1992
Subjects: ING-INF/01 Elettronica

description: The paper describes an analytical, CAD-oriented quasi-2D noise model for AlGaAs-GaAs HEMTs. The model is based on an improved version of the Ando and Itoh approach [2], in which the sheet density of the two-dimensional electron gas (2DEG) as a function of the gate bias is described by a numerical charge control model allowing for deep and shallow donors in the AlGaAs supply layer. The Ando and Itoh's power-law analytical gate control model is then fitted to the numerical charge control model; this yields accurate results in the low-noise operating region of HEMT's. Improved output conductance and low-field mobility models have been implemented to achieve a better agreement with experimental DC data. A critical discussion is presented on the effect of microscopic parameters like the effective thickness of the 2DEG, on the overall noise prediction of the model. Finally, comparisons are presented between the AC and noise model predictions and measurements carried out on a standard 0.5 mm SIEMENS HEMT.
Quasi-2D analysis of travelling gunn domains in microwave MESFET's
Creators: name: Leuzzi, Giorgio
name: Lugli, Paolo
name: Salmer, George
name: Giannini, Franco
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1992
Subjects: ING-INF/01 Elettronica

description: We present a numerical analysis of travelling Gunn domains in GaAs MESFET's based on a quasi-2D hydrodynamical model. The results are shown to be quite accurate in comparison to Monte Carlo simulations, despite the simplicity of the quasi-2D model. A microscopic description of the domain propagation is also given.
Additional file 1 of Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing
Creators: name: Duan, Mengna
name: Zhang, Yan
name: Zhang, Haiyang
name: Meng, Yupeng
name: Qian, Ming
name: Zhang, Guokun
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1.
On the Phase Structure of QCD in a Finite Volume
Creators: name: Braun, Jens
name: Klein, Bertram
name: Schaefer, Bernd-Jochen
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The chiral phase transition in QCD at finite chemical potential and temperature can be characterized for small chemical potential by its curvature and the transition temperature. The curvature is accessible to QCD lattice simulations, which are always performed at finite pion masses and in finite simulation volumes. We investigate the effect of a finite volume on the curvature of the chiral phase transition line. We use functional renormalization group methods with a two flavor quark-meson model to obtain the effective action in a finite volume, including both quark and meson fluctuation effects. Depending on the chosen boundary conditions and the pion mass, we find pronounced finite-volume effects. For periodic quark boundary conditions in spatial directions, we observe a decrease in the curvature in intermediate volume sizes, which we interpret in terms of finite-volume quark effects. Our results have implications for the phase structure of QCD in a finite volume, where the location of a possible critical endpoint might be shifted compared to the infinite-volume case.
description: 11 pages, 3 figures, 4 tables; minor text corrections, one figure added, appendix added, references added, matches PLB version
Case management and care expertise as a prevention approach for adults with intellectual disabilities (FaPP-MgB) : study protocol for a randomized-controlled trial
Creators: name: Nadolny, Stephan
name: Bruland, Dirk
name: Grunwald, Marie
name: Gröndahl, Annika
name: Grammatico, Jessica
name: Richter, Miriam Tariba
name: Grebe, Christian
name: Latteck, Änne-Dörte
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Adults with intellectual disabilities have a higher prevalence of unhealthy eating habits, stress, low levels of mobility, and comparable drug consumption as the general population. Consequently, they suffer from several chronic diseases earlier and more often, but there are fewer prevention and health promotion services including this population. The goal of this study is to determine if an advanced practice nursing approach in the community with home visits is an effective way to improve the health status of adults with intellectual disabilities. Methods: We will conduct a randomized-controlled trial with waiting list design in Hamburg, Germany. Inclusion criteria are diagnosis ICD F70-F79 and exclusion criteria are care level > 3 according to the German Social Code XI or being at the end-of-life. Participants will be block randomized. The intervention consists of advanced practice nurses performing case management, social space analysis, prevention planning, and counseling through four outreach home visits on nutrition, mobility, addiction, and stress. Comparison is usual care. The primary outcome is health status (WHODAS) after 12 months. Secondary outcomes are health-related quality of life (EQ-5D) and resilience (RS-11) after 6 and 12 months. The calculated sample size is 256 with an estimated dropout of 30%. Raters and analysts will be blinded. Analysis will be performed using ANCOVAs. Discussion: By providing case management and utilizing their nursing expertise, advanced practice nurses will provide valuable input and guidance on prevention and health promotion for people with intellectual disabilities. They will close the gap between health and social care, which is prominent in Germany, through cooperation between the existing care sectors.
Die Rolle der Zinktransporter ZIP4, ZIP14 und ZnT9 im Hepatozellulären Karzinom : eine immunhistochemische Studie
Creators: name: Gartmann, Laura
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2018
Subjects: subject: Leberzellkrebs
subject: Zinkstoffwechsel
subject: Carrier-Proteine
subject: 616.9943

description: Als essenzielles Spurenelement ist Zink für wichtige Funktionen der menschlichen Zelle nötig. Verschiedene Zinktransporterproteine gewährleisten die zelluläre Verteilung: Die ZIP (Zinc-Irt-like protein) -Familie besteht aus Influx-Transportern, Gegenspieler sind die ZnT (Zinc-Transporter) -Proteine als Efflux-Transporter. Ein entscheidendes Organ der systemischen Zinkhomöostase ist die Leber. Da ein lokaler Zinkmangel und ein Ungleichgewicht der Zinktransporter-Expression im Verdacht stehen mit Karzinomen assoziiert zu sein, ist die Zielsetzung unserer Studie die Expression von drei ausgewählten Zinktransportern (ZIP4, ZIP14 und ZnT9) im Hepatozellulären Karzinom (HCC) zu ergründen und die Eignung als prognostische Marker für das Überleben zu prüfen. Es wurden insgesamt 138 Biopsien von HCCPatienten immunhistochemisch gefärbt und semiquantitativ ausgewertet. Bei den drei Zinktransporterproteinen konnte eine signifikante Expressionserhöhung im HCC verglichen mit angrenzendem extraläsionalem Gewebe nachgewiesen werden, welche unabhängig von der zugrunde liegenden Lebererkrankung war (AFLD, NAFLD, Virus- Hepatitis, sonstige Ätiologien). Zudem zeigten erhöhte Expressionen von ZIP4, ZIP14 und ZnT9 im Zellkern eine Assoziation mit kürzerer Überlebenszeit. Insgesamt ist zu vermuten, dass die Hepatokarzinogenese eng mit einem veränderten zellulären Zinkstoffwechsel verbunden ist und Zinktransporter als Ziele zukünftiger Therapeutika genutzt werden könnten.
An overview of GaAs MMICs reliability
Creators: name: Magiscrali, F.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1992
Subjects: ING-INF/01 Elettronica

description: This work intends to give an overview of the most important reliability issues for GaAs MMICs; in particular, aspects such as reliability procedures and predominant failure mechanisms will be discussed, highlighting the differences with those of discrete FETs; some of the most relevant reliability figures available from the literature will be presented; finally some comments will be given on common reliability programs running in U.S. and Europe for these devices.
Variation of discrete spectra for non-selfadjoint perturbations of selfadjoint operators
Creators: name: Hansmann, Marcel
Publisher: name: arXiv
Year: 2012
Subjects: subject: Spectral Theory (math.SP)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: Let B=A+K where A is a bounded selfadjoint operator and K is an element of the von Neumann-Schatten ideal S_p with p>1. Let {λ_n} denote an enumeration of the discrete spectrum of B. We show that $\sum_n \dist(λ_n, σ(A))^p$ is bounded from above by a constant multiple of |K|_p^p. We also derive a unitary analog of this estimate and apply it to obtain new estimates on zero-sets of Cauchy transforms.
description: Differences to previous version: Extended Introduction, new Section 5, additional references. To appear in Int. Eq. Op. Theory
Additional file 6 of Herpesvirus infections and Alzheimer’s disease: a Mendelian randomization study
Creators: name: Huang, Shu-Yi
name: Yang, Yu-Xiang
name: Kuo, Kevin
name: Li, Hong-Qi
name: Shen, Xue-Ning
name: Chen, Shi-Dong
name: Cui, Mei
name: Tan, Lan
name: Dong, Qiang
name: Yu, Jin-Tai
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 6. Leave-one-out plots, forest plots, and scatter plots.
Uptake of radionuclides by bryophytes in the Chornobyl exclusion zone
Creators: name: Schmidt, Brigitte
name: Kegler, Felix
name: Steinhäuser, Georg
name: Chyzhevskyi, Ihor
name: Dubchak, Sergiy
name: Ivesic, Caroline
name: Koller-Peroutka, Marianne
name: Laarouchi, Aicha
name: Adlassnig, Wolfram
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 530

description: The “Chernobyl nuclear disaster” released huge amounts of radionuclides, which are still detectable in plants and sediments today. Bryophytes (mosses) are primitive land plants lacking roots and protective cuticles and therefore readily accumulate multiple contaminants, including metals and radionuclides. This study quantifies 137Cs and 241Am in moss samples from the cooling pond of the power plant, the surrounding woodland and the city of Prypiat. Activity concentrations of up to 297 Bq/g (137Cs) and 0.43 Bq/g (241Am) were found. 137Cs contents were significantly higher at the cooling pond, where 241Am was not detectable. Distance to the damaged reactor, amount of original fallout, presence of vascular tissue in the stem or taxonomy were of little importance. Mosses seem to absorb radionuclides rather indiscriminately, if available. More than 30 years after the disaster, 137Cs was washed out from the very top layer of the soil, where it is no more accessible for rootless mosses but possibly for higher plants. On the other hand, 137Cs still remains solved and accessible in the cooling pond. However, 241Am remained adsorbed to the topsoil, thus accessible to terrestrial mosses, but precipitated in the sapropel of the cooling pond.
Enhancement of cross-linking efficiency of hyaluronic acid-based hydrogels cross-linked with 1, 4-butanediol diglycidyl ether
Creators: name: Al-Sibani, Mohammed Abdullah
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 615

description: Unabhängig von verschiedenen Vernetzungsstrategien suchen aktuelle Studien alternative Lösungen für die Vernetzung von Hyaluronsäure mit einem niedrigeren Niveau der chemischen Vernetzer um Komplikationen und Zelltoxizität zu vermeiden. In dieser Studie war es unser Ziel, die Vernetzungseffizienz von HA-basierten Hydrogelen, vernetzt mit 1, 4-Butandiol diglycidyl ether (BDDE) durch verschiedener Verfahrensbedingungen, einschließlich der Reaktionszeit, pH, Temperatur, HA-Konzentration, HA Molekular Gewicht und Mischansatz zu überprüfen. Die Studie ergab, dass die Verfahrensbedingungen mit wenigen Ausnahmen spürbare Auswirkungen auf Vernetzungseffizienz von BDDE-HA-Hydrogelen hatte. Ergebnisse von Hydrogelen 'Eigenschaften wie in vitro-Abbaurate, Quellfähigkeit, morphologische und rheologische Verhalten bestätigt diese Erweiterung. Die Ergebnisse bestätigen, dass die verschiedenen Verfahren relativ Stimuli die Vernetzungseffizienz ohne Ausnutzung übermäßiger Mengen des chemischen Quervernetzers BDDE-HA Hydrogele verbessern könnte.
description: Regardless of various cross-linking strategies, current studies seek alternative solutions for cross-linking hyaluronic acid with a lower level of chemical cross-linker to avoid complications and cell toxicity. In this study, we aimed to enhance the cross-linking efficiency of HA-based hydrogels cross-linked with 1, 4-butanediol diglycidyl ether (BDDE) via studying the effect of various method conditions such as reaction time, pH, temperature, HA concentration, HA molecular weight and mixing approach. The study revealed that the method conditions had noticeable effects on BDDE-HA properties with few exceptions. Finally, the findings confirmed that the method conditions could relatively enhance the cross-linking efficiency of BDDE-HA hydrogels without exploiting excessive amount of the chemical cross-linker.