cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Anti-seizure medications-associated bladder and urethral symptoms: a pharmacovigilance analysis based on the FAERS database
Creators: name: Li, Yanyan
name: Wu, Zhanshen
name: Zhao, Yang
name: Shi, Lei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: In clinical practice, observations have been made regarding bladder and urethral symptoms (BUS), notably urinary frequency and urgency, among patients prescribed the anti-seizure medication (ASM) lacosamide. However, the precise association between ASMs and BUS events in real-world settings remains elusive. Data from the FDA Adverse Event Reporting System (FAERS) database were employed and the analysis focused on ASMs-associated BUS events utilizing disproportionality analysis methods, including the reporting odds ratio (ROR) and the proportional reporting ratio (PRR). Furthermore, co-administration, time to onset of ASMs-associated BUS events, and severity assessments were conducted. Several ASMs demonstrated statistically meaningful associations with BUS signals, notably ezogabine, valproic acid/valproate sodium, and clorazepate (p < 0.05). And ASMs-associated BUS events predominantly occurred within the first week and persisted for more than 180 days afterward. Diazepam, gabapentin, and brivaracetam exhibited distinct risk profiles for severe BUS events compared to valproic acid/sodium valproate (p < 0.05). And the nomogram constructed in this study exhibited robust predictive performance. This study yields valuable insights into the association between ASMs and BUS events, but several limitations warrant consideration. Nonetheless, these findings emphasize the significance of vigilance and proactive management of ASMs-associated BUS events.
Iron-catalyzed deoxygenation and 2-sulfonylation of quinoline N-oxides by sodium sulfinates towards 2-sulfonyl quinolines
Creators: name: Li, Ping
name: Jiang, Yangji
name: Li, Han
name: Dong, Wanrong
name: Peng, Zhihong
name: An, Delie
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: An iron(III)-catalyzed protocol towards 2-sulfonyl quinolines from quinoline N-oxides and sodium sulfinates was herein illustrated. The general and direct option featured for high efficiency (up to 91% yields) and good functional compatibilities (27 examples) in the Fe(III)-catalysis. Moreover, free radical mechanism was proposed for the one-pot deoxygenation and sulfonylation reaction based on the results of the control reactions. An novel reaction between quinoline N-oxides and sodium sulfinates for the synthesis of 2-sulfonyl quinolines was herein achieved by an iron(III)-catalyzed system. The general and direct transformation exhibited high efficiency (up to 91% yields) and good functional-groups compatibilities (27 examples). Moreover, free radical mechanism was proposed for the one-pot deoxygenation and sulfonylation reaction based on the results of the control reactions.
Piecewise Mixture Modeling for Longitudinal Virologic Data with Heterogeneity, Non-normality and Missingness
Creators: name: Yangxin Huang
name: Chunning Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: It is a common practice to analyze complex longitudinal data arisen frequently in medical studies using nonlinear mixed-effects (NLME) or nonparametric mixed-effects (NPME) models in the literature. However, the following issues may standout in AIDS longitudinal data analysis: (i) In clinical practice, the profile of each subject's virologic response may follow a “broken stick” like trajectory, indicating multiple phases of decline and increase in response. Such multiple phases (with change-points) may be an important indicator to help quantify treatment effect and improve management of patient care. To estimate change-points, NLME or NPME models become a challenge due to complicated structures of model formulations; (ii) a homogeneous population assumption in models may be unrealistically obscuring important features of between- and within-subject variations; (iii) normality assumption for model errors may not always give robust and reliable results, in particular, if the data exhibit non-normality; and (iv) the responses may be missing and the missingness may be non-ignorable. When statistical inference is carried out in such settings, it is important to account for the effects of these data features; otherwise, erroneous or even misleading results may be produced. Inferential procedures can be complicated dramatically when data with heterogeneous, non-normal (skewed) and missing characteristics are observed in conjunction with change-points as unknown parameters into models. There has been relatively little study concerning all these features simultaneously. There is a need to fill up this gap as longitudinal data do often have these features. In this article, our objectives are to study simultaneous impact of these data features by developing Bayesian modeling approach-based Finite Mixture of Hierarchical Change-point (FMHC) models with skew distributions, allowing estimates of both model parameters and class membership probabilities at population and individual levels. An HIV/AIDS clinical data example is analyzed to demonstrate the proposed methodologies, and to compare various scenarios-based potential models.
Development of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations
Creators: name: Zhang, Zongrui
name: Wang, Xinyu
name: Li, Binbin
name: Hou, Yuanjing
name: Yang, Jing
name: Yi, Li
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Sustained release of therapeutic agents into tumor cells is a potential approach to improve therapeutic efficacy, decrease side effects, and the drug administration frequency. Herein, we used the modified double-emulsion solvent evaporation (DSE) method to prepare a novel morphological paclitaxel (PTX) loaded poly(lactide-co-glycolide) (PLGA) microspheres (MS). The prepared rough PTX-PLGA-MS possessed microporous surface and highly porous internal structures, which significantly influenced the drug entrapment and release behaviors. The rough MS with an average particle size of 53.47 ± 2.87 μm achieved high drug loading (15.63%) and encapsulation efficiency (92.82%), and provided a favorable sustained drug release. The in vitro antitumor tests of flow cytometry and fluoroimmunoassay revealed that the rough PTX-PLGA-MS displayed effective anti-gliomas activity and enhanced the cellular PTX uptake through adsorptive endocytosis. Both in vitro and in vivo antitumor results demonstrated that the sustained-release PTX could induce the microtubules assembly and the over-expression of Bax and Cyclin B1 proteins, resulting in the microtubule dynamics disruption, G2/M phase arrest, and cell apoptosis accordingly. Furthermore, as the rough PTX-PLGA-MS could disperse and adhere throughout the tumor sites and cause extensive tumor cell apoptosis with one therapeutic course (12 days), they could reduce the system toxicity and drug administration frequency, thus achieving significant tumor inhibitory effects with rapid sustained drug release. In conclusion, our results verified that the rough PTX-PLGA-MS drug release system could serve as a promising treatment to malignant glioma.
On Theoretically Optimal Ranking Functions in Bipartite Ranking
Creators: name: Uematsu, Kazuki
name: Yoonkyung Lee
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Neuroscience
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: This article investigates the theoretical relation between loss criteria and the optimal ranking functions driven by the criteria in bipartite ranking. In particular, the relation between area under the ROC curve (AUC) maximization and minimization of ranking risk under a convex loss is examined. We characterize general conditions for ranking-calibrated loss functions in a pairwise approach, and show that the best ranking functions under convex ranking-calibrated loss criteria produce the same ordering as the likelihood ratio of the positive category to the negative category over the instance space. The result illuminates the parallel between ranking and classification in general, and suggests the notion of consistency in ranking when convex ranking risk is minimized as in the RankBoost algorithm for instance. For a certain class of loss functions including the exponential loss and the binomial deviance, we specify the optimal ranking function explicitly in relation to the underlying probability distribution. In addition, we present an in-depth analysis of hinge loss optimization for ranking and point out that the RankSVM may produce potentially many ties or granularity in ranking scores due to the singularity of the hinge loss, which could result in ranking inconsistency. The theoretical findings are illustrated with numerical examples. Supplementary materials for this article are available online.
Joint Selection in Mixed Models using Regularized PQL
Creators: name: Hui, Francis K. C.
name: Müller, Samuel
name: A. H. Welsh
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The application of generalized linear mixed models presents some major challenges for both estimation, due to the intractable marginal likelihood, and model selection, as we usually want to jointly select over both fixed and random effects. We propose to overcome these challenges by combining penalized quasi-likelihood (PQL) estimation with sparsity inducing penalties on the fixed and random coefficients. The resulting approach, referred to as regularized PQL, is a computationally efficient method for performing joint selection in mixed models. A key aspect of regularized PQL involves the use of a group based penalty for the random effects: sparsity is induced such that all the coefficients for a random effect are shrunk to zero simultaneously, which in turn leads to the random effect being removed from the model. Despite being a quasi-likelihood approach, we show that regularized PQL is selection consistent, that is, it asymptotically selects the true set of fixed and random effects, in the setting where the cluster size grows with the number of clusters. Furthermore, we propose an information criterion for choosing the single tuning parameter and show that it facilitates selection consistency. Simulations demonstrate regularized PQL outperforms several currently employed methods for joint selection even if the cluster size is small compared to the number of clusters, while also offering dramatic reductions in computation time. Supplementary materials for this article are available online.
Trends in Relative Abundance and Early Life Survival of Atlantic Menhaden during 1977–2013 from Long-Term Ichthyoplankton Programs
Creators: name: Simpson, Cara A.
name: Wilberg, Michael J.
name: Hongsheng Bi
name: Schueller, Amy M.
name: Nesslage, Geneviève M.
name: Walsh, Harvey J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The Atlantic Menhaden Brevoortia tyrannus, a commercially important clupeid, supports one of the oldest and largest commercial fisheries on the U.S. East Coast. Despite recent increases in adult biomass, juvenile indices have declined coastwide and have remained particularly low in Chesapeake Bay. In order to understand the underlying causes of this decline, knowledge of larval recruitment is essential. We developed an index of larval abundance by using larval data collected from two large-scale ichthyoplankton sampling programs that occurred from Nova Scotia, Canada, to Cape Hatteras, North Carolina, during 1977–1987 and 1999–2013. Larval abundance data were standardized to a day-0 age by applying an age–length key from a study of larval ingress into Chesapeake Bay; a delta-lognormal model was used to account for spatial and temporal changes in sampling. We found that Atlantic Menhaden larval abundance increased from 1977 to 2013 and was highest in the winter; most individuals were detected at nearshore stations. Over our time series, larval abundance corresponded closely to adult spawning stock biomass. Due to the lack of a direct relationship between our larval abundance estimates and a coastwide juvenile index, we examined several environmental factors (temperature, Chesapeake Bay discharge, Atlantic Multidecadal Oscillation [AMO], wind speed, and wind direction) for potential effects on the relative survival of larvae. Larval abundance had a significant negative effect on relative survival. Temperature and to a lesser extent wind speed and AMO appeared to exert the greatest effects on the early life survival of Atlantic Menhaden: cooler temperatures, intermediate wind speeds, and negative-phase AMO were the most favorable for survival. Our findings suggest that the observed reduction in recruitment is not a problem of larval supply but rather is limited by survival between the larval and juvenile stages. Received December 17, 2015; accepted May 31, 2016 Published online August 12, 2016
ИЧКИ ИШЛАР ОРГАНЛАРИНИНГ ТАНОСИЛ ЁКИ ОИВ/ОИТСНИ ЮҚТИРИШНИНГ САБАБЛАРИ ВА ТАРҚАЛИШИНИ ОЛДИНИ ОЛИШНИНГ АСОСИЙ ЙЎНАЛИШЛАРИ
Creators: name: Курбанбаев, М.У.
Publisher: name: Zenodo
Year: 2024

description: Мақолада таносил ёки ОИВ касаллиги (ОИТС)ни тарқатиш билан боғлиқ жиноятларнинг тушунчаси, ҳуқуқий тавсифи, ушбу жиноятнинг таркибий элементлари, унинг ижтимоий хавфи кўрсатиб ўтилган. Шунингдек ушбу турдаги жиноятларга қарши курашишнинг ҳуқуқий асослари, қарши курашиш бўйича белгиланган субъектлар ва улар томонидан амалга оширилиши лозим бўлган айрим жиҳатлар кўриб чиқилган.
Chemical constituents and antitumor activity from Paris polyphylla Smith var. yunnanensis
Creators: name: Songsong Jing
name: Wang, Ying
name: Li, Xia
name: Shuli Man
name: Wenyuan Gao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Eleven compounds were isolated from the rhizomes of Paris polyphylla Smith var. yunnanensis. Their structures were elucidated on the basis of rigorous 1D and 2D NMR experiments as well as comparison with the literature data. To the best of our knowledge, compound 1 was only predicted by UPLC/Q-TOF MSE and the NMR spectroscopic data was given for the first time. The cytotoxic activities of all compounds on mouse B16 cells were evaluated. Among the tested molecules, compounds 6–9 showed strong cytotoxicities, while compound 1 did not show significant effect.
Structural analysis of a micron-sized Cu0 in a person with diabetes's insulin ball
Creators: name: Iwaya, Keiichi
name: Nagase, Terumasa
name: Zako, Tamotsu
name: Itoh, Yoshiyuki
name: Takashima, Yoshiko
name: Arai, Hisae
name: Nagami, Nobumasa
name: Ishikawa, Takashi
name: Sugimura, Haruhiko
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 401607
subject: Metals and alloy materials
classificationCode: 320507
subject: Metabolic medicine
classificationCode: 429999
subject: Other health sciences not elsewhere classified

description: Insulin preparations are indispensable for patients with diabetes to maintain optimal blood sugar (glucose). Insulin preparations can form insoluble amyloid structure in the subcutaneous adipose tissue called "insulin ball" when repeatedly injected into the same site. We found copper without an oxidized state (Cu0) within insulin balls. Copper is known to accumulate in such living things as plants and bacteria, we found the largest copper mass in living organisms within an insulin ball of a 47-year-old woman with diabetes. Copper is essential for living organisms, but too much can be poisonous. Copper ion concentrations have been thought to be strictly regulated in vivo. Our finding of the largest copper mass within amyloid aggregates made of extrinsic insulin preparations raises new questions for the life sciences.
Correlation between environmental pollutant exposure and cardiopulmonary health by serum biomarker analysis in the Swedish elderly population
Creators: name: Pak, Youngmi Kim
name: Im, Suyeol
name: Choi, Hoon Sung
name: Lind, Lars
name: Lind, Monica
name: Lee, Hong Kyu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Persistent organic pollutants (POPs) affect human health through the aryl hydrocarbon receptor (AhR) pathway and are implicated in mitochondrial dysfunction. Using data from the PIVUS study, we investigated the associations of serum AhR ligand (POP)-mediated luciferase activity (AhRL), mitochondrial ATP production inhibiting substances (MIS-ATP), and those affecting reactive oxygen species (MIS-ROS) with several metabolic syndrome (MetS) and cardiopulmonary function parameters. These include insulin resistance (HOMA-IR), inflammation, oxidative stress, and cardiopulmonary variables (FVC, FEV1, LV-EF, CCA distensibility). MIS-ATP showed significant correlations with HOMA-IR and pulmonary functions, indicating its direct impact of MIS-ATP on metabolic and pulmonary health. MIS-ROS correlated with oxidative stress markers and CCA distensibility, suggesting a role in systemic inflammatory responses. This study highlights the intricate relationships between environmental pollutant mixture and cardiopulmonary health in MetS as indicated by biomarkers of POP exposure in the elderly population, suggesting POP exposure may influence MetS onset and progression through mitochondrial dysfunction.
Analyse des alternatives disponibles pour les entreprises des zones occupées par les rebelles du M23 en R.D. Congo face à l'indisponibilité des services bancaires : Cas de la ville de Goma
Creators: name: KABENE CIRANVU, James
Publisher: name: Zenodo
Year: 2025
Subjects: Alternatives financières, Services bancaires, Résilience financière, association villageoise d'épargne, mobile money.

description: Cet article analyse les alternatives financières adoptées par les entreprises de Goma en réponse à l’indisponibilité des services bancaires causée par l’occupation des rebelles du M23. L’étude repose sur une approche quantitative menée auprès de 30 dirigeants d’entreprises. Les résultats révèlent que la majorité font recourent aux Associations Villageoises d’Épargne et de Crédit (AVEC), des crédits informels ou accèdent aux distributeurs automatiques de billets au Rwanda. L'utilisation de ces alternatives permet aux entreprises de maintenir leurs activités malgré les défis économiques et sécuritaires. Cependant, ces solutions ne sont pas exemptées de risques, notamment des taux d’intérêt élevés, un manque de protection juridique et une exposition accrue aux fluctuations monétaires. Bien que ces mécanismes palliatifs permettent une certaine stabilité, des solutions plus institutionnelles doivent être envisagées pour garantir une meilleure inclusion financière à long terme.
Table S4. Midge sequences included in this study with their GenBank accession numbers from The largest early-diverging angiosperm family is mostly pollinated by ovipositing insects and so are most surviving lineages of early angiosperms
Creators: name: Luo, Shi-Xiao
name: Zhang, Lian-Jie
name: Yuan, Shuai
name: Ma, Zhong-Hui
name: Zhang, Diang-Xiang
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2020

description: Insect pollination in basal angiosperms is assumed to mostly involve ‘generalized' insects looking for food, but direct observation of ANITA grade (283 species) pollinators are sparse. We present new data for numerous Schisandraceae, the largest ANITA family, from fieldwork, nocturnal filming, electron microscopy, barcoding and molecular clocks to infer pollinator/plant interactions over multiple years at sites throughout China to test the extent of pollinator specificity. Schisandraceae are pollinated by nocturnal gall midges that lay eggs in the flowers and whose larvae then feed on floral exudates. At least three Schisandraceae have shifted to beetle pollination. Pollination by a single midge species predominates, but one species was pollinated by different species at three locations and one by two at the same location. Based on molecular clocks, gall midges and Schisandraceae may have interacted since at least the Early Miocene. Combining these data with a review of all published ANITA pollination data shows that ovipositing flies are the most common pollinators of living representatives of the ANITA grade. Compared to food reward-based pollination, oviposition-based systems are less wasteful of plant gametes because (i) none are eaten and (ii) female insects with herbivorous larvae reliably visit conspecific flowers.
SPARQLing Geodesy for Cultural Heritage: New Opportunities for Publishing and Analysing Volunteered Linked (Geo-)Data
Creators: name: Thiery, Florian
name: Schmidt, Sophie Charlotte
name: Homburg, Timo
name: Trognitz, Martina
name: Przybilla, Monika
Publisher: name: Zenodo
Year: 2020
Subjects: Ogham
Linked Data
Wikidata
SPARQL Unicorn
QGIS

description: Geodesists are working in Industry 4.0 and Spatial Information Management by using cross linked machines, people and data. Moreover, open source software, open geodata and open access are becoming increasingly important. As part of the Semantic Web, Linked Open Data (LOD) must be created and published in order to provide free open geodata in interoperable formats. With this semantically structured and standardised data it is easy to implement tools for GIS applications e.g. QGIS. In these days, the world’s Cultural Heritage (CH) is being destroyed as a result of wars, sea-level rise, floods and other natural disasters by climate change. Several transnational initiatives try to preserve our CH via digitisation initiatives. As best practice for preserving CH data serves the Ogi Ogam Project with the aim to show an easy volunteered approach to modelling Irish `Ogam Stones` containing Ogham inscriptions in Wikidata and interlinking them with spatial information in OpenStreetMap and (geo)resources on the web.
An application of an integrated ANP–QFD framework for sustainable supplier selection
Creators: name: Tavana, Madjid
name: Yazdani, Morteza
name: Caprio, Debora Di
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: This study provides a novel integrated multi-criteria decision-making approach to sustainable supplier selection problems. Despite the large supply chain management literature on green performance measurement, the need for a systematic analysis of how specific sustainable variables develop and affect each other remains mostly overlooked. The proposed integrated framework allows for such an analysis. By combining analytic network process and quality function deployment, our model identifies a clear hierarchical structure for all the relevant sustainable factors and sub-factors while weighting the decision criteria based on the importance given to customer requirements. Finally, suppliers are ranked using a multi-objective optimisation procedure based on ratio analysis and weighted aggregated sum product assessment. The proposed framework is used to analyse a case study of a dairy company, but it can be easily implemented for supplier selection by any other company with similar features.
Unlocking the potential of Allium dictyoprasum C.A. Meyer ex Kunth: quantum chemical insights into radical scavenging, chemical composition, phenolic content, and antimicrobial activity
Creators: name: Tegin, İbrahim
name: Yabalak, Erdal
name: Hallaç, Bülent
name: Sabancı, Nazmiye
name: Fidan, Mehmet
name: Sadık, Betül
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Allium dictyoprasum C.A. Meyer ex Kunth (A. dictyoprasum) underwent comprehensive analysis, encompassing quantum chemical computations to assess its radical scavenging potential, chemical and elemental composition, total phenolic content, and antimicrobial activity. Experimental and theoretical investigations focused on elucidating the radical scavenging properties of polyhydroxy phenolic compounds present in the plant. Quantum chemical calculations were employed to evaluate the antioxidants employed to evaluate selected polyhydroxy phenolic molecules including flavonoids, hydrocinnamic acid derivatives, and hydroxybenzoic acid derivatives from natural sources. Thermochemical parameters of these compounds were calculated by the B3LYP/6–311 G++(d,p) level in both gas and solvent phases to elucidate the radical scavenging mechanism including hydrogen atom transfer (HAT), single electron transfer followed by proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET). Analysis of A. dictyoprasum extracts obtained via various extraction methods revealed the presence of several major compounds, including dimethyl trisulfide, 3,5-Dihydroxy-6-methyl-2,3-dihydro-4 H-pyran-4-one, 2-Methoxy-4-vinylphenol, Dimethyl phthalate, Methyl palmitate, Methyl oleate, Methyl stearate, (9Z)-9-Octadecenamide. Notably, Malic acid and Quinic acid were identified as major compounds, with concentrations of 43.31 and 17.47 mg kg−1 extract, respectively, based on LC-MS/MS analysis. The total phenolic content of the extract was measured as 17.83 mg gallic acid/mL, while its free radical scavenging activity was 80.89% per mg/mL. Elemental analysis revealed significant levels of Mg, K, Na, Fe, and P, with minor concentrations of elements such as Ti, Tl, B, and Be. Furthermore, A. dictyoprasum exhibited notable antibacterial activity against various bacteria strains, surpassing the efficacy of some commercial antibiotics. Quantum chemical calculations of radical scavenging analysis were performed. Thermochemical parameters were calculated by the B3LYP/6–311 G++(d,p) level. Radical scavenging mechanism was evaluated based on HAT, SET-PT and SPLET. Chemical composition of Allium dictyoprasum C.A. Meyer ex Kunth was determined. A. dictyoprasum has a greater antibacterial effects than some commercial antibiotics.
Supplementary Figure S1 from The largest early-diverging angiosperm family is mostly pollinated by ovipositing insects and so are most surviving lineages of early angiosperms
Creators: name: Luo, Shi-Xiao
name: Zhang, Lian-Jie
name: Yuan, Shuai
name: Ma, Zhong-Hui
name: Zhang, Diang-Xiang
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2020

description: Insect pollination in basal angiosperms is assumed to mostly involve ‘generalized' insects looking for food, but direct observation of ANITA grade (283 species) pollinators are sparse. We present new data for numerous Schisandraceae, the largest ANITA family, from fieldwork, nocturnal filming, electron microscopy, barcoding and molecular clocks to infer pollinator/plant interactions over multiple years at sites throughout China to test the extent of pollinator specificity. Schisandraceae are pollinated by nocturnal gall midges that lay eggs in the flowers and whose larvae then feed on floral exudates. At least three Schisandraceae have shifted to beetle pollination. Pollination by a single midge species predominates, but one species was pollinated by different species at three locations and one by two at the same location. Based on molecular clocks, gall midges and Schisandraceae may have interacted since at least the Early Miocene. Combining these data with a review of all published ANITA pollination data shows that ovipositing flies are the most common pollinators of living representatives of the ANITA grade. Compared to food reward-based pollination, oviposition-based systems are less wasteful of plant gametes because (i) none are eaten and (ii) female insects with herbivorous larvae reliably visit conspecific flowers.
Fungal endophyte Phomopsis liquidambari B3 enriches the diversity of nodular culturable endophytic bacteria associated with continuous cropping of peanut
Creators: name: Wu, Jia-Rui
name: Xu, Fang-Ji
name: Cao, Wei
name: Zhang, Wei
name: Guan, Yong-Xiang
name: Dai, Chuan-Chao
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Previously, the application of the fungal endophyte Phomopsis liquidambari B3 exhibited notable effect in alleviating soil obstacles caused by continuous cropping of peanut. It was supposed that P. liquidambari B3 could enhance the efficiency of nodulation and nitrogen fixation by enriching the diversity of nodular endophytic bacteria under continous monocropping system. To verify this hypothesis, a pot experiment was conducted under natural conditions. Four treatments were set as follow: discontinuous cropping soil (NS), continuous cropping soil (CK), continuous cropping soil inoculate with actived P. liquidambari B3 (CSB3), and continuous cropping soil inoculate with sterilized P. liquidambari B3 (CSIB3). As a result, a total of 120 isolates were obtained. Our study clearly declared that the addition of fungal endophyte effectively enriched the genetic diversity and the community composition in CSB3. In contrast, a low genetic diversity level and simplex community structure were exhibited in CK and CSIB3. Meanwhile, the positive percentage rate and corresponding community composition of the plant growth-promoting isolates in NS and CSB3 were larger and more abundant than the other. This is the first time to describe the effects of fungal endophytes on the diversity of the nodular culturable endophytic bacteria associated with continuous cropping of peanut.
Genetic Status and Conservation of Westslope Cutthroat Trout in Glacier National Park
Creators: name: Muhlfeld, Clint C.
name: D’Angelo, Vincent S.
name: Downs, Christopher
name: Powell, John
name: Amish, Stephen
name: Luikart, Gordon
name: Kovach, Ryan
name: Boyer, Matthew
name: Kalinowski, Steven
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Invasive hybridization is one of the greatest threats to the persistence of Westslope Cutthroat Trout Oncorhynchus clarkii lewisi. Large protected areas, where nonhybridized populations are interconnected and express historical life history and genetic diversity, provide some of the last ecological and evolutionary strongholds for conserving this species. Here, we describe the genetic status and distribution of Westslope Cutthroat Trout throughout Glacier National Park, Montana. Admixture between Westslope Cutthroat Trout and introduced Rainbow Trout O. mykiss and Yellowstone Cutthroat Trout O. clarkii bouvieri was estimated by genotyping 1,622 fish collected at 115 sites distributed throughout the Columbia, Missouri, and South Saskatchewan River drainages. Currently, Westslope Cutthroat Trout occupy an estimated 1,465 km of stream habitat and 45 lakes (9,218 ha) in Glacier National Park. There was no evidence of introgression in samples from 32 sites along 587 km of stream length (40% of the stream kilometers currently occupied) and 17 lakes (2,555 ha; 46% of the lake area currently occupied). However, nearly all (97%) of the streams and lakes that were occupied by nonhybridized populations occurred in the Columbia River basin. Based on genetic status (nonnative genetic admixture ≤ 10%), 36 Westslope Cutthroat Trout populations occupying 821 km of stream and 5,482 ha of lakes were identified as “conservation populations.” Most of the conservation populations (N = 27; 736 km of stream habitat) occurred in the Columbia River basin, whereas only a few geographically restricted populations were found in the South Saskatchewan River (N = 7; 55 km) and Missouri River (N = 2; 30 km) basins. Westslope Cutthroat Trout appear to be at imminent risk of genomic extinction in the South Saskatchewan and Missouri River basins, whereas populations in the Columbia River basin are widely distributed and conservation efforts are actively addressing threats from hybridization and other stressors. A diverse set of pro-active management approaches will be required to conserve, protect, and restore Westslope Cutthroat Trout populations in Glacier National Park throughout the 21st century. Received September 10, 2015; accepted March 30, 2016 Published online August 12, 2016
title: 02_0488
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Aminoglycoside-stimulated readthrough of premature termination codons in selected genes involved in primary ciliary dyskinesia
Creators: name: Bukowy-Bieryllo, Zuzanna
name: Dabrowski, Maciej
name: Michał Witt
name: Zietkiewicz, Ewa
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Translational readthrough of premature termination codons (PTCs) induced by pharmacological compounds has proven to be an effective way of restoring functional protein expression and reducing symptoms in several genetic disorders. We tested the potential of different concentrations of several aminoglycosides (AAGs) for promoting PTC-readthrough in 5 genes involved in the pathogenesis of primary ciliary dyskinesia, an inherited disorder caused by the dysfunction of motile cilia and flagella. The efficiency of readthrough stimulation of PTCs cloned in dual reporter vectors was examined in 2 experimental settings: in vitro (transcription/translation system) and ex vivo (transiently transfected epithelial cell line). PTC-readthrough was observed in 5 of the 16 mutations analyzed. UGA codons were more susceptible to AAG-stimulated readthrough than UAG; no suppression of UAA was observed. The efficiency of PTC-readthrough in vitro (from less than 1% to ∼28% of the translation from the corresponding wild-type constructs) differed with the AAG type and concentration, and depended on the combination of AAG and PTC, indicating that each PTC has to be individually tested with a range of stimulating compounds. The maximal values of PTC suppression observed in the ex vivo experiments were, depending on AAG used, 3–5 times lower than the corresponding values in vitro, despite using AAG concentrations that were 2 orders of magnitude higher. This indicates that, while the in vitro system is sufficient to examine the readthrough-susceptibility of PTCs, it is not sufficient to test the compounds potential to stimulate PTC-readthrough in the living cells. Most of the tested compounds (except for G418) at their highest concentrations did not disturb ciliogenesis in the cultures of primary respiratory epithelial cells from healthy donors.
T&F Supplementary.docx
Creators: name: Supriyanto, Hajar Mar’atussolikah
name: d'Arqom, Annette
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 321401
subject: Basic pharmacology

description: This is a supplementary file for the manuscript entitled Sunshine in a Capsule: Vitamin D’s Role in Neuropathic Pain – A systematic review.
Table S2. Study sites, observation times, and herbarium vouchers for studied plants from The largest early-diverging angiosperm family is mostly pollinated by ovipositing insects and so are most surviving lineages of early angiosperms
Creators: name: Luo, Shi-Xiao
name: Zhang, Lian-Jie
name: Yuan, Shuai
name: Ma, Zhong-Hui
name: Zhang, Diang-Xiang
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2020

description: Insect pollination in basal angiosperms is assumed to mostly involve ‘generalized' insects looking for food, but direct observation of ANITA grade (283 species) pollinators are sparse. We present new data for numerous Schisandraceae, the largest ANITA family, from fieldwork, nocturnal filming, electron microscopy, barcoding and molecular clocks to infer pollinator/plant interactions over multiple years at sites throughout China to test the extent of pollinator specificity. Schisandraceae are pollinated by nocturnal gall midges that lay eggs in the flowers and whose larvae then feed on floral exudates. At least three Schisandraceae have shifted to beetle pollination. Pollination by a single midge species predominates, but one species was pollinated by different species at three locations and one by two at the same location. Based on molecular clocks, gall midges and Schisandraceae may have interacted since at least the Early Miocene. Combining these data with a review of all published ANITA pollination data shows that ovipositing flies are the most common pollinators of living representatives of the ANITA grade. Compared to food reward-based pollination, oviposition-based systems are less wasteful of plant gametes because (i) none are eaten and (ii) female insects with herbivorous larvae reliably visit conspecific flowers.
title: 01_0764
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Searching new targets to counter drug resistance – GTPase-Obg mRNA expression analysis in Mycobacterium under stress and in silico docking with GTPase inhibitors
Creators: name: Vikrant Kumar
name: Himanshu Narayan Singh
name: Tomar, Anil Kumar
name: Subrahamanyam Dantham
name: Yadav, Savita
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Searching new targets to counter drug resistance – GTPase-Obg mRNA expression analysis in Mycobacterium under stress and in silico docking with GTPase inhibitors
Table S5. Midge eggs and larvae found in the flowers of representative Schisandraceae from The largest early-diverging angiosperm family is mostly pollinated by ovipositing insects and so are most surviving lineages of early angiosperms
Creators: name: Luo, Shi-Xiao
name: Zhang, Lian-Jie
name: Yuan, Shuai
name: Ma, Zhong-Hui
name: Zhang, Diang-Xiang
name: Renner, Susanne S.
Publisher: name: The Royal Society
Year: 2020

description: Insect pollination in basal angiosperms is assumed to mostly involve ‘generalized' insects looking for food, but direct observation of ANITA grade (283 species) pollinators are sparse. We present new data for numerous Schisandraceae, the largest ANITA family, from fieldwork, nocturnal filming, electron microscopy, barcoding and molecular clocks to infer pollinator/plant interactions over multiple years at sites throughout China to test the extent of pollinator specificity. Schisandraceae are pollinated by nocturnal gall midges that lay eggs in the flowers and whose larvae then feed on floral exudates. At least three Schisandraceae have shifted to beetle pollination. Pollination by a single midge species predominates, but one species was pollinated by different species at three locations and one by two at the same location. Based on molecular clocks, gall midges and Schisandraceae may have interacted since at least the Early Miocene. Combining these data with a review of all published ANITA pollination data shows that ovipositing flies are the most common pollinators of living representatives of the ANITA grade. Compared to food reward-based pollination, oviposition-based systems are less wasteful of plant gametes because (i) none are eaten and (ii) female insects with herbivorous larvae reliably visit conspecific flowers.
Effects of indoor environments and outdoor air pollutants in residential areas on acute exacerbation in patients with severe asthma
Creators: name: Kim, Byung-Keun
name: Kim, Hwan-Cheol
name: Lee, Dong-Wook
name: Nam, Young-Hee
name: Sim, Da Woon
name: Lee, Youngsoo
name: Shim, Ji-Su
name: Yang, Min-Suk
name: Kim, Min-Hye
name: Kim, So Ri
name: Kim, Sang-Heon
name: Koh, Young-Il
name: Park, Heung-Woo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (p = 0.014 and 0.0016, respectively). The mean concentration of PM2.5 in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 ± 3.1 vs. 21.0 ± 2.5 µg/m3, p = 0.033). Moreover, the serum level of 8-hydroxy-2′-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 ± 30.0 vs. 94.7 ± 44.5 ng/mL, p = 0.0047) suggesting enhanced oxidative stress in those with AE.