cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Basal nucleotide levels, release, and metabolism in normal and cystic fibrosis airways.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: BACKGROUND: Cystic fibrosis (CF) is a syndrome caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. Despite advances in our understanding of the molecular pathogenesis of CF, the link between CFTR gene mutations and the pathogenesis of CF lung disease remains poorly defined. CFTR has been assigned a number of putative functions that may contribute to innate airway defense, including the regulation of adenosine 5'-triphosphate (ATP) release into the extracellular environment. Because extracellular ATP and uridine 5'-triphosphate (UTP) may regulate airway mucociliary clearance via interaction with luminal P2Y2 receptors, the loss of CFTR-mediated nucleotide release could explain the defect in CF airway defense. MATERIALS AND METHODS: We tested the physiologic importance of CFTR-mediated nucleotide release in vivo by directly measuring levels of ATP and UTP in nasal airway surface liquid from normal and CF subjects. Because these basal nucleotide levels reflect the net activities of nucleotide release and metabolic pathways, we also measured constitutive rates of nucleotide release and metabolism on well-differentiated normal and CF airway cultures in vitro. The measurement of ATP release rates were paralleled by in vivo studies employing continuous nasal perfusion in normal and CF subjects. Finally, the regulation of ATP release by isoproterenol and methacholine-stimulated submucosal gland secretion was tested. RESULTS: These studies revealed that steady-state ATP and UTP levels were similar in normal (470 +/- 131 nM and 37 +/- 7 nM, respectively) and CF (911 +/- 199 nM and 33 +/- 12 nM, respectively) subjects. The rates of both ATP release and metabolism were also similar in normal and CF airway epithelia both in vitro and in vivo. Airway submucosal glands did not secrete nucleotides, but rather, secreted a soluble nucleotidase in response to cholinergic stimuli. CONCLUSION: The concentration of ATP in airway surface liquid is in a range that is relevant for the activation of airway nucleotide receptors. However, despite this finding that suggests endogenous nucleotides may be important for the regulation of mucociliary clearance, our data do not support a role for CFTR in regulating extracellular nucleotide concentrations on airway surfaces.
Size structure of river zooplankton: seasonal variation, overall pattern and functional aspect
Creators: name: Kobayashi, Tsuyoshi
name: Shiel, Russell J
name: Gibbs, Philip
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Density-size distributions of a river zooplankton community were examined about biweekly over a year in the upper tidal freshwater portion of a regulated Australian river, specifically the Hawkesbury-Nepean, Results were compared with those of similar studies in lakes (and reservoirs) to characterize the similarities and differences in the structure and grazing function of river and lake zooplankton communities. The density-size distributions of the river zooplankton community were similar to those of lake plankton communities, in terms of a marked temporal variation in shape and overall bimodal shape. They differed in terms of the truncation of the upper body size and the absence of a significant relationship between the slope (regression coefficient) of a log-linear density-size model and environmental variables. The river zooplankton community appeared to have a high average rate of biomass increase when measured against body-mass class and a low mass-specific grazing rate, compared with those of lake communities. Because of methodological differences between studies, intersystem comparisons of size spectra and grazing rates need cautious interpretations and generalizations.
Additional file 4 of Targeting the MALAT1 gene with the CRISPR/Cas9 technique in prostate cancer
Creators: name: Ahmadi-Balootaki, Soraya
name: Doosti, Abbas
name: Jafarinia, Mojtaba
name: Goodarzi, Hamed Reza
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 4: Figure S1. (A) Prostate tumors and non-carcinoma tissue samples have different DElncRNAs. Differentially elevated lncRNAs are shown by red dots, down-regulated lncRNAs are represented by green dots, and black dots represent no genes. (B) The differentially expressed lncRNAs in prostate cancer and normal tissues were studied using unsupervised hierarchical clustering. (C) Multivariate Cox regression analysis generated a forest map of 2 lncRNAs. Figure S2. The ability of two lncRNAs based on the signature to predict prognosis for PC patients from the TCGA database. Figure S3. (A) Based on TCGA data, the two-lncRNA nomogram’s prediction capacity was assessed using Kaplan-Meier analysis, log-rank P, and C-index. The Kaplan-Meier curves depict and compare OS time between low- and high-risk groups. (B) The predictive ability of two-lncRNA nomograms based on ICGC data was assessed using Kaplan-Meier analysis, Log-rank P, and C-index. (C) The findings of the TCGA multivariate analysis showed that the 2-lncRNA signature might be used as a powerful predictor of PC OS rate compared to other clinicopathological variables. (D) The findings of the ICGC multivariate analysis revealed that 2-lncRNA features might be utilized to predict PC OS rate in the absence of other clinicopathological variables.
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: BACKGROUND: Relatively few genes have been shown to directly affect the metastatic phenotype of breast cancer epithelial cells in vivo. The Rho family of proteins, incluing the Rho, Rac and Cdc42 subfamilies, are related to the small GTP binding protein Ras and regulated diverse biological processes including gene transcription, cytoskeletal organization, cell proliferation and transformation. The effects of Cdc42, Rac and Rho on the actin cytoskeleton suggested a possible role for Rho proteins in cellular motility and metastasis; however, a formal analysis of the role of Rho proteins in breast cancer cellular growth and metastasis in vivo had not previously been performed. MATERIALS AND METHODS: We generated a panel of MTLn3 rat mammary adenocarcinoma cells that expressed similar levels of dominant inhibitory mutants of Cdc42-, Rac- and Rho-dependent signaling, to examine the contribution of these GTPases to cell spreading, guided chemotaxis, and metastasis in vivo. The ability of Rho proteins to regulate intravasation into the peripheral blood was determined by implanting MTLn3 cell stable dominant negative lines in nude mice and measuring the formation of breast cancer cell colonies grown from the peripheral blood. Serial sectioning of the lungs was performed to determine the presence of metastasis in mice in which mammary tumors expressing the dominant negative Rho family proteins had grown to a similar size. RESULTS: Cell spreading of MTLn3 cells was selectively abrogated by N17Rac1. N19RhoA and N17Cdc42 reduced the number of focal contacts (FCs) and disrupted the co-localization of vinculin with phosphotyrosine at FCs. While N17Rac1 and N17Cdc42 preferentially inhibited colony formation in soft agar, all three GTPases affected cell growth in vivo. To distinguish effects on tumorigenicity from intravasation into the bloodstream, implanted tumors were grown to the same size in nude mice. Each dominant inhibitory Rho protein reduced intravasation into the peripheral blood. Lung metastasis of MTLn3 cells was also abrogated by the dominant inhibitory Rho proteins, despite the presence of residual CFU. CONCLUSIONS: These studies demonstrate for the first time a critical role for the Rho GTPases involving independent signaling pathways to limit mammary tumor cellular growth and metastasis in vivo.
An End-to-End Multi-Task Learning Model for Image-based Table Recognition
Creators: name: Ly, Nam Tuan
name: Takasu, Atsuhiro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Image-based table recognition is a challenging task due to the diversity of table styles and the complexity of table structures. Most of the previous methods focus on a non-end-to-end approach which divides the problem into two separate sub-problems: table structure recognition; and cell-content recognition and then attempts to solve each sub-problem independently using two separate systems. In this paper, we propose an end-to-end multi-task learning model for image-based table recognition. The proposed model consists of one shared encoder, one shared decoder, and three separate decoders which are used for learning three sub-tasks of table recognition: table structure recognition, cell detection, and cell-content recognition. The whole system can be easily trained and inferred in an end-to-end approach. In the experiments, we evaluate the performance of the proposed model on two large-scale datasets: FinTabNet and PubTabNet. The experiment results show that the proposed model outperforms the state-of-the-art methods in all benchmark datasets.
description: 10 pages, VISAPP2023. arXiv admin note: substantial text overlap with arXiv:2303.07641
Spreading of intolerance under economic stress: results from a model with reputation
Creators: name: Martinez-Vaquero, Luis A.
name: Cuesta, José A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: When a population is engaged in successive prisoner's dilemmas, indirect reciprocity through reputation fosters cooperation through the emergence of moral and action rules. A simplified model has recently been proposed where individuals choose between helping or not others, and are judged good or bad for it by the rest of the population. The reputation so acquired will condition future actions. In this model, eight strategies (referred to as 'leading eight') enforce a high level of cooperation, generate high payoffs and are therefore resistant to invasions by other strategies. Here we show that, by assigning each individual one out of two labels that peers can distinguish (e.g., political ideas, religion, skin colour...) and allowing moral and action rules to depend on the label, intolerant behaviours can emerge within minorities under sufficient economic stress. We analyse the sets of conditions where this can happen and also discuss the circumstances under which tolerance can be restored. Our results agree with empirical observations that correlate intolerance and economic stress, and predict a correlation between the degree of tolerance of a population and its composition and ethical stance.
description: 13 pages, 10 figures, uses RevTeX1.4
Energy-Efficient Antenna Selection and Power Allocation for Large-Scale Multiple Antenna Systems with Hybrid Energy Supply
Creators: name: Zhou, Zhenyu
name: Zhou, Sheng
name: Gong, Jie
name: Niu, Zhisheng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: The combination of energy harvesting and large-scale multiple antenna technologies provides a promising solution for improving the energy efficiency (EE) by exploiting renewable energy sources and reducing the transmission power per user and per antenna. However, the introduction of energy harvesting capabilities into large-scale multiple antenna systems poses many new challenges for energy-efficient system design due to the intermittent characteristics of renewable energy sources and limited battery capacity. Furthermore, the total manufacture cost and the sum power of a large number of radio frequency (RF) chains can not be ignored, and it would be impractical to use all the antennas for transmission. In this paper, we propose an energy-efficient antenna selection and power allocation algorithm to maximize the EE subject to the constraint of user's quality of service (QoS). An iterative offline optimization algorithm is proposed to solve the non-convex EE optimization problem by exploiting the properties of nonlinear fractional programming. The relationships among maximum EE, selected antenna number, battery capacity, and EE-SE tradeoff are analyzed and verified through computer simulations.
description: IEEE Globecom 2014 Selected Areas in Communications Symposium-Green Communications and Computing Track
Genes Involved in Viral Carcinogenesis and Tumor Initiation in Hepatitis C Virus–Induced Hepatocellular Carcinoma
Creators: name: Maluf, Daniel
name: Mas, Valeria
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The role of chronic hepatitis C virus (HCV) in the pathogenesis of HCV-associated hepatocellular carcinoma (HCC) remains controversial. To understand the transition from benign to malignant, we studied the gene expression patterns in liver tissues at different stages, including normal, cirrhosis, and different HCC stages. We studied 108 liver tissue samples obtained from 88 distinct patients (41 HCV-cirrhotic tissues, 17 HCV-cirrhotic tissues from patients with HCC, and 47 HCV-HCC tissues). Differentially expressed genes (DEG) were studied by use of high-density oligonucleotide arrays. Among probe sets identified as differentially expressed via the F test, all pairwise comparisons were performed. Cirrhotic tissues with and without concomitant HCC were further evaluated, and a classifier was used to predict whether the tissue type was associated with HCC. Differential expression profiles were analyzed using Interaction Networks and Functional Analysis. Characteristic gene signatures were identified when normal tissue was compared with cirrhosis, cirrhosis with early HCC, and normal with HCC. Pathway analysis classified the cellular and biological functions of the DEG as related to cellular growth and proliferation, cell death and inflammatory disease in cirrhosis; cell death, cell cycle, DNA replication, and immune response in early HCCs; and cell death, cell growth and proliferation, cell cycle, and DNA repair in advanced HCCs. Characteristic gene signatures were identified at different stages of HCV-HCC progression. A set of genes were identified to predict whether the cirrhotic tissue was associated with HCC.
A convergence rates result for an iteratively regularized Gauss-Newton-Halley method in Banach space
Creators: name: Kaltenbacher, Barbara
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65F22, 65N20

description: The use of second order information on the forward operator often comes at a very moderate additional computational price in the context of parameter identification probems for differential equation models. On the other hand the use of general (non-Hilbert) Banach spaces has recently found much interest due to its usefulness in many applications. This motivates us to extend the second order method previously considered by the author in a Hilbert space setting, (see also Hettlich and Rundell 2000) to a Banach space setting and analyze its convergence. We here show rates results for a particular source condition and different exponents in the formulation of Tikhonov regularization in each step. This includes a complementary result on the (first order) iteratively regularized Gauss-Newton method (IRGNM) in case of a one-homogeneous data misfit term, which corresponds to exact penalization. The results clearly show the possible advantages of using second order information, which get most pronounced in this exact penalization case. Numerical simulations for a coefficient identification problem in an elliptic PDE illustrate the theoretical findings.
Additional file 1 of AMPDeep: hemolytic activity prediction of antimicrobial peptides using transfer learning
Creators: name: Salem, Milad
name: Keshavarzi Arshadi, Arash
name: Yuan, Jiann Shiun
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. A Word document containing the additional methodology and results.
title: Falcon: High Performance Supercomputer
Creators: name: Idaho C3+3 Collaboration
Publisher: name: University of Idaho
Year: 2022
Subjects: subject: FOS: Electrical engineering, electronic engineering, information engineering
valueUri: http://www.oecd.org/science/inno/38235147.pdf
subject: FOS: Engineering and technology
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Falcon is an SGI ICE X supercomputer currently operated and used by a consortium of Idaho research universities (University of Idaho, Boise State University, Idaho State University). Falcon is owned by Idaho National Laboratory (INL) and ranked 97th on the Top500 list of the world’s fastest supercomputers when it was operationalized in 2014 and significantly upgraded in 2017. Through a Memorandum of Understanding (January 2022), management and use of Falcon was transferred to the Idaho research computing consortium.

Falcon is located in the INL Collaborative Computing Center (C3) facility in Idaho Falls, Idaho, USA. It currently consists of approximately 932 nodes with dual Intel Xeon E5-2695v4 18-core processors running at 2.1 GHz (36 cores per node) for a total of 33,552 cores capable of more than 1 PetaFLOPS of compute capacity. Each node on Falcon is configured with 128 GB of RAM for a total of about 120TB of overall system memory, uses an Infiniband-based interconnect configured as a 7-dimensional hypercube, and uses a 1.3 petabyte fault-tolerant Lustre filesystem.

Falcon represents an order-of-magnitude increase in high performance computing under direct management and use by Idaho university researchers. Faculty, staff, and students from the three Idaho universities access Falcon free of charge. Falcon is connected to the universities via the Idaho Regional Optical Network (IRON) which enables high speed data transfers to both local and remote compute centers.

Current specifications for Falcon can be found at https://c3plus3.org/falcon/
Account access can be obtained at https://docs.c3plus3.org/
Information about Idaho Regional Optical Network (IRON) is available at https://ironforidaho.net/
Simulations of pre-supernova feedback in spherical clouds
Creators: name: Kourniotis, Michalis
name: Wünsch, Richard
name: Martínez-González, Sergio
name: Palouš, Jan
name: Tenorio-Tagle, Guillermo
name: Ehlerová, Soňa
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a one-dimensional radiation-hydrodynamic model of a spherically symmetric cloud evolving under the influence of the self-gravity and the feedback from a star cluster forming in its centre. On one hand, the model is simple due to its 1D geometry, on the other hand, the feedback includes the ionising radiation, stellar winds and the radiation pressure acting on gas and dust. The star cluster is formed from the gas flowing into the cloud centre and the feedback parameters are determined from stellar evolution models and the cluster star forming history. The model is compared to the semi-analytic code WARPFIELD implementing similar physical processes and exploring the scenario that the young cluster R136 in the Large Magellanic Cloud was formed due to re-collapse of the shell formed by the previous generation star cluster. A good qualitative agreement is found, however, $3 - 4$ times higher stellar mass is needed to disrupt the cloud in our model, because it takes into account (contrary to WARPFIELD) self-gravity of the cloud surrounding the shell. We use the model to explore star formation in clouds with different mass, radius and density profile measuring their star formation efficiency (SFE), i.e. the fraction of the cloud mass converted to stars. We found that SFE is a function of a single parameter, $\mathrm{log(SFE)} \propto -n_{hm}^{-0.46}$, with $n_{hm}$ being the cloud mean particle density within its half-mass radius. Furthermore, we found that the feedback efficiency, i.e. a fraction of the feedback energy retained by gas, has a nearly constant value $\sim 10^{-3}$.
description: 15 pages including appendix, 11 figures. Accepted for publication in MNRAS
Additional file 1 of The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis
Creators: name: Gao, He
name: Zhao, Ying
name: Zhao, Sai
name: Dai, Xiao-Qiu
name: Qin, Xiao-Yuan
name: Zheng, Wei-Long
name: He, Ting-Ting
name: Zhang, Nan
name: Zhu, Can
name: Wang, Hong-Min
name: Pan, Wen
name: Zhu, Xue-Mei
name: Gao, Xiao-Ming
name: Dai, Jian-Feng
name: Gong, Fang-Yuan
name: Wang, Jun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table S1. gRNA and primer sequences used in this study; Figure S1. Little impact of Zbtb24-deficiency on the phenotype of B cells in the periphery of mice; Figure S2. No effect of Zbtb24-deficiency on the phenotype and number of GCB cells after TD-Ag immunization; Figure S3. Deficiency of Zbtb24 in B cells has no impact on the long-term antibody responses in mice after NP19-OVA/alum immunization; Figure S4. Reduced total antibody-producing ability of Zbtb24B−CKO splenic B cells after adoptive transfer; Figure S5. Grossly intact CSR abiltiy of Zbtb24B−CKO B cells; Figure S6. Little effect of Zbtb24-deficiency in hematopoietic cells on humoral responses against TD-Ags in mice. Figure S7. Comparable numbers of NP+ B cells in Cd19Cre/+ and Zbtb24B−CKO mice on D35 after NP-Ficoll immunization; Figure S8. Reduced numbers of NP+ B1 cells in Zbtb24B−CKO mice after NP-LPS immunization; Figure S9. Zbtb24-deficiency has no impact on the differentiation and antibody-producing ability of splenic B cells in vitro; Figure S10. Zbtb24-deficiency does not compromise the survival, activation and proliferation of Zbtb24B−CKO B cells in vitro; Figure S11. Dysregulated genes/signaling pathways in Zbtb24-deficient B1 cells; Figure S12. No effect of Zbtb24-deficiency on heme metabolism in stimulated splenic B cells. Figure S13. Little impact of Zbtb24-depletion on the phosphorylation of CD19, AKT and ribosomal protein S6 (S6) in splenic B cells.
Peptide-Based Inhibition of NF-κB Rescues Diaphragm Muscle Contractile Dysfunction in a Murine Model of Duchenne Muscular Dystrophy
Creators: name: Kline, William
name: Peterson, Jennifer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Deterioration of diaphragm function is one of the prominent factors that contributes to the susceptibility of serious respiratory infections and development of respiratory failure in patients with Duchenne Muscular Dystrophy (DMD). The NF-κB signaling pathway has been implicated as a contributing factor of dystrophic pathology, making it a potential therapeutic target. Previously, we demonstrated that pharmacological inhibition of NF-κB via a small NEMO Binding Domain (NBD) peptide was beneficial for reducing pathological features of mdx mice. Now, we stringently test the effectiveness and clinical potential of NBD by treating mdx mice with various formulations of NBD and use diaphragm function as our primary outcome criteria. We found that administering DMSO-soluble NBD rescued 78% of the contractile deficit between mdx and wild-type (WT) diaphragm. Interestingly, synthesis of a GLP NBD peptide as an acetate salt permitted its solubility in water, but as a negative consequence, also greatly attenuated functional efficacy. However, replacing the acetic acid counterion of the NBD peptide with trifluoroacetic acid retained the peptide’s water solubility and significantly restored mdx diaphragm contractile function and improved histopathological indices of disease in both diaphragm and limb muscle. Together, these results support the feasibility of using a mass-produced, water-soluble NBD peptide for clinical use.
Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate–Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein–Dependent Mechanism
Creators: name: Tadie, Jean-Marc
name: Bae, Hong-Beom
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Despite the potent antiinflammatory effects of pharmacologically induced adenosine 5′-monophosphate kinase (AMPK) activation on Toll-like receptor 4 (TLR4)-induced cellular activation, there is little evidence that AMPK is activated during inflammatory conditions. In the present studies, we examined mechanisms by which TLR4 engagement may affect the ability of AMPK to become activated in neutrophils and macrophages under in vitro conditions and in the lungs during lipopolysaccharide (LPS)-induced acute lung injury. We found that incubation of neutrophils or macrophages with LPS diminished the ability of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) or hydrogen peroxide (H2O2) to activate AMPK. Although ratios of AMP to adenosine 5′-triphosphate (ATP) were increased in LPS-treated neutrophils and in the lungs of LPS exposed mice, a condition that should result in AMPK activation, no activation of AMPK was found. Immunocytochemistry and Western blot analysis revealed that nuclear to cytosolic translocation of the proinflammatory mediator high mobility group box 1 protein (HMGB1) correlated with inhibition of AMPK activation in LPS-stimulated macrophages. Moreover, while induced overexpression of HMGB1 resulted in inhibition of AMPK activation, Small interfering RNA (siRNA)-induced knockdown of HMGB1 was associated with enhanced activation of AMPK in macrophages incubated with AICAR. Increased interaction between liver kinase B1 (LKB1), an upstream activator of AMPK, and HMGB1 was found in LPS-stimulated macrophages and in the lungs of mice exposed to LPS. These results suggest that nuclear to cytoplasmic translocation of HMGB1 in TLR4-activated cells potentiates inflammatory responses by binding to LKB1, thereby inhibiting the antiinflammatory effects of AMPK activation.
The role of implicit affective responses and trait self-control in ego resource management
Creators: name: Buczny, Jacek
name: Muraven, Mark
name: Layton, Rebekah L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Exertion of self-control requires reliance on ego resources. Impaired performance typically results once those resources have been depleted by previous use. Yet the mechanism behind the depletion processes is little understood. Beliefs, motivation, and physiological changes have been implicated, yet the source behind these remains unknown. We propose that implicit may form the fundamental building blocks that these processes rely upon to operate. Implicit affective responses to energy may trigger management of ego resources after depletion. Findings suggest that inhibitory trait self-control may interact with the depletion effect, indicating the importance of taking individual differences in chronic availability of ego-resources into account. After depletion, individuals high in trait self-control may be less motivated to conserve remaining resources than those low in self-control. This mechanism may also help explain the conservation of resources observed when expecting multiple tasks requiring self-control.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Il saggio mira a interpretare l’opera Il Giardino di Ciro (1658) del medico e intellettuale inglese Thomas Browne sotto un punto di vista estetico, simbolico ed iniziatico. Partendo dalla vicinanza, metaforica e pratica tra studio anatomico e letteratura tipica del ’600 europeo, questo studio correla la figura del quincunx (la disposizione a losanga degli alberi che è il tema del Giardino di Ciro) alle concezioni scientifiche e metafisiche della pelle e dell’apparato tegumentario. Rintracciando uno spostamento, all’interno del trattato, da un piano fisico a un piano metafisico e, conseguentemente, un’evoluzione terminologica da quincunx a texture, la figura del quincunx viene messa in relazione con i rimandi alla filosofia ermetica e pitagorica presenti nell’opera. In particolare, la presenza di riferimenti ai geroglifici egiziani di matrice kircheriana e alle valenze soteriologiche ed iniziatiche del simbolo della croce sono analizzate puntualmente per evidenziare l’aspetto metafisico e teologico dell’opera, che a una prima lettura si presenta come un curioso trattato di botanica. In conclusione, si prospetta una lettura alchemica del Giardino di Ciro, tesa a riconoscere nell’atto della dissezione il nucleo matriciale del trattato e della tecnica compositiva e intertestuale dello stesso. Il quincunx viene ad essere interpretato allora come il dispositivo simbolico che permette a Thomas Browne di ordinare la realtà e di trovare un senso metafisico alla stessa.
description: The essay aims to interpret the treatise The Garden of Cyrus (1658) by the English physician and intellectual Thomas Browne from an aesthetic, symbolic, and initiatory point of view. Starting from the proximity, both metaphorical and practical, between anatomical studies and literature typical of seventeenth-century Europe, this study correlates the figure of the quincunx (the lozenge-shaped arrangement of trees that is the theme of The Garden of Cyrus) with scientific and metaphysical conceptions of the skin and integumentary apparatus. Tracing a shift, within the treatise, from a physical to a metaphysical plane and, consequently, a terminological progression from quincunx to texture, the figure of the quincunx is related to the many references to hermetic and Pythagorean philosophy present in the work. In particular, the presence of references to Kircher’s Egyptian hieroglyphics and to the soteriological and initiatory values of the symbol of the cross are punctually analyzed to highlight the metaphysical and theological aspect of the work, which on first reading appears as a curious botanical treatise. In conclusion, the paper proposes an alchemic reading of The Garden of Cyrus, to recognize in the act of dissection the matrix core of the treatise and its compositional and intertextual technique. The quincunx comes to be interpreted then as the symbolic device that allows Browne to order reality and find a metaphysical meaning to it.
No evidence for parental imprinting of mouse 22q11 gene orthologues
Creators: name: Hamer, Robert M.
name: Maynard, Thomas M.
name: Peters, Amanda Z.
name: Lieberman, Jeffrey A.
name: LaMantia, Anthony-Samuel
name: Meechan, Daniel W.
name: Heindel, Clifford C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Non-mendelian factors may influence CNS phenotypes in patients with 22q11 deletion syndrome (22q11DS, also known as DiGeorge or Velocardiofacial Syndrome), and similar mechanisms may operate in mice carrying a deletion of one or more 22q11 gene orthologues. Accordingly, we examined the influence of parent of origin on expression of 25 murine 22q11 orthologues in the developing and mature CNS using SNP-based analysis in interspecific crosses, as well as quantification of mRNA in a murine model of 22q11DS. We found no evidence for absolute genomic imprinting or silencing. All 25 genes are biallelically expressed in the developing and adult brain. Furthermore, if more subtle forms of allelic biasing are present, they are very small in magnitude, and most likely beyond the resolution of currently available quantitative approaches. Given the high degree of similarity of human 22q11 and the orthologous region of mmChr16, genomic imprinting most likely cannot explain apparent parent-of-origin effects in 22q11DS.
The hunt for the G-bacteria in activated sludge biomass
Creators: name: Maszenan, A. M
name: Seviour, R. J
name: Patel, B. K. C
name: Rees, G. N
name: McDougall, B
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Routine microscopic examination of biomass samples from many activated sludge plants around the world reveals the presence of large numbers of both Gram positive and Gram negative coccoid cells often arranged in distinctive tetrads or sheets of tetrads. Three Gram negative tetrad cocci were successfully isolated into pure culture using micromanipulation from samples of biomass from plants in Tamworth, N.S.W., Australia, Verona, Italy and Macau. After extensive phenotypic characterisation and 16S rDNA sequence analysis, all isolates showed high overall similarity to each other, but were phylogenetically quite different to any previously sequenced bacterium. They have therefore been classified as three species of a new genus, the genus Amaricoccus in the a Proteobacteria in the domain Bacteria. None could accumulate polyphosphate granules, and production of intracellular poly-beta-hydroxybutyrate (PHB) granules depended on the carbon source used in the medium. A similar characterisation of the original isolate of the G-bacteria described by Cech and Hartman showed this organism also belonged to the same genus as the other three isolates, but as a distinct species. The practical implications of these observations are discussed.
Multiwavelength monitoring of the nucleus in PBC J2333.9-2343: the giant radio galaxy with a blazar-like core
Creators: name: Hernández-García, L.
name: Panessa, F.
name: Bruni, G.
name: Bassani, L.
name: Arévalo, P.
name: Patiño-Alvarez, V. M.
name: Tramacere, A.
name: Lira, P.
name: Sánchez-Sáez, P.
name: Bauer, F. E.
name: Chavushyan, V.
name: Carraro, R.
name: Förster, F.
name: Arancibia, A. M. Muñoz
name: Ubertini, P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: PBC J2333.9-2343 is a giant radio galaxy at z = 0.047 with a bright central core associated to a blazar nucleus. If the nuclear blazar jet is a new phase of the jet activity, then the small orientation angle suggest a dramatic change of the jet direction. We present observations obtained between September 2018 and January 2019 (cadence larger than three days) with Effeslberg, SMARTS-1.3m, ZTF, ATLAS, Swift, and Fermi-LAT, and between April-July 2019 (daily cadence) with SMARTS-1.3m and ATLAS. Large (>2x) flux increases are observed on timescales shorter than a month, which are interpreted as flaring events. The cross correlation between the SMARTS-1.3m monitoring in the NIR and optical shows that these data do not show significant time lag within the measured errors. A comparison of the optical variability properties between non-blazars and blazars AGN shows that PBC J2333.9-2343 has properties more comparable to the latter. The SED of the nucleus shows two peaks, that were fitted with a one zone leptonic model. Our data and modelling shows that the high energy peak is dominated by External Compton from the dusty torus with mild contribution from Inverse Compton from the jet. The derived jet angle of 3 degrees is also typical of a blazar. Therefore, we confirm the presence of a blazar-like core in the center of this giant radio galaxy, likely a Flat Spectrum Radio Quasar with peculiar properties.
description: Accepted for publication in MNRAS. 15 pages, 6 figures, 2 appendix including tables and figures
The limnology of Lake Torrens, an episodic salt lake of central Australia, with particular reference to unique events in 1989
Creators: name: Williams, W. D
name: De Deckker, P
name: Shiel, R. J
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Lake Torrens, a large (similar to 6000 km(2)), episodic, saline playa lake in arid central Australia, filled for the first recorded time in March 1989. This unique event followed unprecedently heavy rain over its catchment. Water remained in the lake until early 1990. Salinities remained low (< 40 g l(-1)) until November 1989, then increased rapidly to > 200 g l(-1) before the water evaporated completely. Na and Cl probably dominated the ions. Twenty-nine taxa of aquatic animals were recorded. Crustaceans dominated and of these Parartemia minuta (anostracan), Daphniopsis queenslandensis and Moina baylyi (cladocerans), and several species of ostracods were the most important. Other significant taxa included Tanytarsus barbitarsis (chironomid), Brachionus plicatilis (rotifer) and Craterocephalus eyresii (fish). The fauna was dominated by widespread forms that are either part of a distinct assemblage found widely in central Australian salt lakes (especially P, minuta, D. queenslandensis, M. baylyi and Trigonocypris subglobusus [ostracod]), or cosmopolitan forms (B. plicatilis), or forms found widely in Australian salt lakes (e.g. Diacypris compacta, Tanytarsus barbitarsis). However, possibly three new species also occurred: a new species of a new genus of mytilocypridinid, Branchinella nov.sp. and Heterocypris is nov. sp. Their occurrence is anomolous. It is suggested that further work will show that they too are widely distributed. Both genera of the latter two taxa are typical of temporary waters and specimens may have been washed in from nearby water-bodies. Sixty-four species of bird were recorded when the lake contained water, many breeding. The breeding of the banded stilt (Cladorhynchus leucocephalus) was notable; breeding of this species had been unknown in South Australia since 1930. A large population built up until breeding was stopped by predation from the silver gull (Larus novaehollandiae). When dry, the lake has a depauperate but well-defined and regionally restricted 'terrestrial' fauna (scorpions, spiders, beetles, ants).
On the structure and evolution of planets and their host stars $-$ effects of various heating mechanisms on the size of giant gas planets
Creators: name: Yıldız, M.
name: Orhan, Z. Çelik
name: Kayhan, C.
name: Turkoglu, G. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: It is already stated in the previous studies that the radius of the giant planets is affected by stellar irradiation. The confirmed relation between radius and incident flux depends on planetary mass intervals. In this study, we show that there is a single relation between radius and irradiated energy per gram per second ($l_-$), for all mass intervals. There is an extra increase in radius of planets if $l_-$ is higher than 1100 times energy received by the Earth ($l_\oplus$). This is likely due to dissociation of molecules. The tidal interaction as a heating mechanism is also considered and found that its maximum effect on the inflation of planets is about 15 per cent. We also compute age and heavy element abundances from the properties of host stars, given in the TEPCat catalogue (Southworth 2011). The metallicity given in the literature is as [Fe/H]. However, the most abundant element is oxygen, and there is a reverse relation between the observed abundances [Fe/H] and [O/Fe]. Therefore, we first compute [O/H] from [Fe/H] by using observed abundances, and then find heavy element abundance from [O/H]. We also develop a new method for age determination. Using the ages we find, we analyse variation of both radius and mass of the planets with respect to time, and estimate the initial mass of the planets from the relation we derive for the first time. According to our results, the highly irradiated gas giants lose 5 per cent of their mass in every 1 Gyr.
description: 15 pages, 13 figures, 3 tables. Accepted by MNRAS
Monmouth University Poll: November 2015 South Carolina Primary
Creators: name: Monmouth University Polling Institute
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Registered to vote (1); do you plan to register to vote (1); voter likelihood (1); Republican/Democratic presidential primary (2); Republican presidential primary choice (5); favorability of Republican presidential candidates (7); Democratic presidential primary choice (4); favorability of Democratic presidential candidates (3); Presidential Candidate Hillary Clinton addressing concerns of African-Americans (1); Presidential Candidate Hillary Clinton addressing concerns of women (1); Presidential Candidate Bernie Sanders addressing concerns of African-Americans (1); Presidential Candidate Bernie Sanders addressing concerns of women (1); Tea Party (1).
THE MAN IN THE BACKSEAT: A REFLECTION ON THE PROJECTION DESIGN PROCESS OF HOOKMAN
Creators: name: Preston, Sean
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Design
subject: Hookman
subject: Projection Design
subject: Reflection
subject: Theatre

description: The following thesis navigates the artistic ideas and concepts, design process,and execution of Sean Preston’s projection design for the UMD School for Theatre Dance and Performance Studies-College Park’s production of Hookman. The production opened November 13th, 2021 in the Kogod Theatre at the Clarice Smith Performing Arts Center. Hookman was directed by Nathaniel P. Claridad, with scenic design by Mollie Singer, costume design by Stephanie Parks, lighting design by Heather Reynolds, and sound design by Tosin Olufolabi.
Additional file 1 of Comparison of catastrophic out-of-pocket medical expenditure among older adults in the United States and South Korea: what affects the apparent difference?
Creators: name: Kim, Narae
name: Jacobson, Mireille
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Science Policy
Computational Biology

description: Additional file 1: Figure 1. Percentage of Older Adults in Different Categories of the Proportion of Annual Household Income Spent as an Out-of-Pocket Spending on Health Care by Various Subgroups.
Additional file 3 of The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis
Creators: name: Gao, He
name: Zhao, Ying
name: Zhao, Sai
name: Dai, Xiao-Qiu
name: Qin, Xiao-Yuan
name: Zheng, Wei-Long
name: He, Ting-Ting
name: Zhang, Nan
name: Zhu, Can
name: Wang, Hong-Min
name: Pan, Wen
name: Zhu, Xue-Mei
name: Gao, Xiao-Ming
name: Dai, Jian-Feng
name: Gong, Fang-Yuan
name: Wang, Jun
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Uncropped WB membranes.
The Production of $Ξ_{bb}$ at Photon Collider
Creators: name: Yang, Zhong-Juan
name: Zhao, Xiao-Xia
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The inclusive production of the doubly heavy baryon $Ξ_{bb}$ is investigated at polarized and unpolar- ized photon collider. bb pair in both color triplet and sextet have been considered to transform into $Ξ_{bb}$. The results indicate that the contribution from color sextet is about 8% for $Ξ_{bb}$ production. For the ILC collision energy ranging from 91GeV to 1000GeV, the total cross section of $Ξ_{bb}$ shows a downtrend, i.e., the production of $Ξ_{bb}$ has the maximal rate at $\sqrt S = 91GeV$. Our results indicate that the initial beam polarization may be an important asset for the production of $Ξ_{bb}$. At some collision point, the production rate of $Ξ_{bb}$ can be increased about 17% with an appropriate choice of the initial beam polarization.
description: 6 pages,10 figures
Additional file 2 of Comparison of catastrophic out-of-pocket medical expenditure among older adults in the United States and South Korea: what affects the apparent difference?
Creators: name: Kim, Narae
name: Jacobson, Mireille
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Science Policy
Computational Biology

description: Additional file 2: Figure 2. Average Inpatient & Outpatient Service Utilization of Two Years by Age Categories and Income Quartiles in the US and South Korea.
Transitions between Aulacoseira and Anabaena dominance in a turbid river Weir pool
Creators: name: Sherman, Bradford S
name: Webster, Ian T
name: Jones, Gary J
name: Oliver, Rod L
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

The transitions between the diatoms Aulacoseira spp. (Melosira) and the cyanobacteria Anabaena spp, as dominant phytoplankton species in a turbid-river weir pool are shown to depend directly on the establishment or destruction of persistent thermal stratification. A transition from high to low flow through the pool resulted in the establishment of persistent thermal stratification, causing Aulacoseira to sink out of the euphotic zone at a speed of 0.95 m d(-1). Concurrently, the slightly buoyant Anabaena grew within the euphotic zone with a specific growth rate of 0.37 d(-1), climaxing after approximately 14 d at a population of 20,000-30,000 cells ml(-1), at which point its biomass may have been limited by the availability of phosphorus. The stratification thus caused the phytoplankton population to separate into two distinct layers, with Anabaena occupying the illuminated surface layer and Aulacoseira found only in the lower layer below the euphotic depth. Under stratified conditions, the ratio of the surface layer depth to euphotic depth, z(s1):z(eu) was approximately 1, whereas for a mixed water column that ratio was >3. Access to light appeared to be the main factor determining the dominant phytoplankton species.