cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Canine CNGA3 gene mutations provide novel insights into human achromatopsia-associated channelopathies and treatment
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Amino Acid Sequence
Animals
Channelopathies
Color Vision Defects
Cyclic Nucleotide-Gated Cation Channels
Dogs
Humans
Ion Channel Gating
Leucine Zippers
Molecular Dynamics Simulation
Molecular Sequence Data
Mutation

description: © 2015 Tanaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cyclic nucleotide-gated (CNG) ion channels are key mediators underlying signal transduction in retinal and olfactory receptors. Genetic defects in CNGA3 and CNGB3, encoding two structurally related subunits of cone CNG channels, lead to achromatopsia (ACHM). ACHM is a congenital, autosomal recessive retinal disorder that manifests by cone photoreceptor dysfunction, severely reduced visual acuity, impaired or complete color blindness and photophobia. Here, we report the first canine models for CNGA3-associated channelopathy caused by R424W or V644del mutations in the canine CNGA3 ortholog that accurately mimic the clinical and molecular features of human CNGA3-associated ACHM. These two spontaneous mutations exposed CNGA3 residues essential for the preservation of channel function and biogenesis. The CNGA3-R424W results in complete loss of cone function in vivo and channel activity confirmed by in vitro electrophysiology. Structural modeling and molecular dynamics (MD) simulations revealed R424-E306 salt bridge formation and its disruption with the R424Wmutant. Reversal of charges in a CNGA3- R424E-E306R double mutant channel rescued cGMP-activated currents uncovering new insights into channel gating. The CNGA3-V644del affects the C-terminal leucine zipper (CLZ) domain destabilizing intersubunit interactions of the coiled-coil complex in the MD simulations; the in vitro experiments showed incompetent trimeric CNGA3 subunit assembly consistent with abnormal biogenesis of in vivo channels. These newly characterized large animal models not only provide a valuable system for studying cone-specific CNG channel function in health and disease, but also represent prime candidates for proof-ofconcept studies of CNGA3 gene replacement therapy for ACHM patients.
The Relativity of Quantum Phenomena_0R
Creators: name: Anonymous, W.
Publisher: name: Zenodo
Year: 2020
Subjects: Quantum theory
Relativity theory
Double-slit experiment
Wave–particle duality
EPR paradox
Entropy
Dark Energy
Curvature
Probability

description: Abstract: This article aims to reinterpret the hidden principle and mechanism of the double-slit experiment in a more comprehensible manner, and to demonstrate a new perspective that better clarifies existent phenomena. This new perspective involves conducting the observation and analysis at a relative angle, which can partially reconcile the divergence between the quantum theory and the relativity theory. Several concepts are redefined from a relative viewpoint. In the proposed interpretation, the wave–particle duality observed in typical double-slit experiments gives only a surface appearance of certainty. The non-locality hidden in special relativity theory, which can also be found from a relative viewpoint, can subsequently be used to explain weird quantum behaviors, as well as other classic theories like principle of least action. The considerations on concept of relativity are applicable to other cosmological phenomena such as dark energy or dark matter, providing a more comprehensible explanation than conventional thinking. A series of other doubtful phenomena, such as probability of quantum events, can also be reasonably comprehended in light of the present conclusions. And finally, possible application directions are cautiously forecasted. *Correspondence to: WM.Anonymous@hotmail.com
Conformational Mechanics of Polymer Adsorption Transitions at Attractive Substrates
Creators: name: Möddel, Monika
name: Bachmann, Michael
name: Janke, Wolfhard
Publisher: name: arXiv
Year: 2009
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Conformational phases of a semiflexible off-lattice homopolymer model near an attractive substrate are investigated by means of multicanonical computer simulations. In our polymer-substrate model, nonbonded pairs of monomers as well as monomers and the substrate interact via attractive van der Waals forces. To characterize conformational phases of this hybrid system, we analyze thermal fluctuations of energetic and structural quantities, as well as adequate docking parameters. Introducing a solvent parameter related to the strength of the surface attraction, we construct and discuss the solubility-temperature phase diagram. Apart from the main phases of adsorbed and desorbed conformations, we identify several other phase transitions such as the freezing transition between energy-dominated crystalline low-temperature structures and globular entropy-dominated conformations.
description: 13 pages, 15 figures
The Kitchen Table Theory
Creators: name: Hunt, Guy
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Telomere fragment induced amnion cell senescence: A contributor to parturition?
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Adolescent
Adult
Amnion
Animals
Cells, Cultured
Cellular Senescence
Cross-Sectional Studies
DNA Damage
Enzyme Activation
Epithelial Cells
Female
Humans
Male
Mice
Obstetric Labor, Premature
Parturition
Pregnancy
Telomere
Tumor Suppressor Protein p53
Young Adult
p38 Mitogen-Activated Protein Kinases

description: © 2015 Polettini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Oxidative stress (OS)-induced senescence of the amniochorion has been associated with parturition at term. We investigated whether telomere fragments shed into the amniotic fluid (AF) correlated with labor status and tested if exogenous telomere fragments (T-oligos) could induce human and murine amnion cell senescence. In a cross-sectional clinical study, AF telomere fragment concentrations quantitated by a validated real-time PCR assay were higher in women in labor at term compared to those not in labor. In vitro treatment of primary human amnion epithelial cells with 40 μMT-oligos ([TTAGGG]2) thatmimic telomere fragments, activated p38MAPK, produced senescence-associated (SA) β-gal staining and increased interleukin (IL)-6 and IL-8 production compared to cells treated with complementary DNA sequences (Cont-oligos, [AATCCC]2). T-oligos injected into the uteri of pregnant CD1 mice on day 14 of gestation, led to increased p38MAPK, SA-β-gal (SA β-gal) staining in murine amniotic sacs and higher AF IL-8 levels on day 18, compared to saline treated controls. In summary, term labor AF samples had higher telomere fragments than term not in labor AF. In vitro and in situ telomere fragments increased human and murine amnion p38MAPK, senescence and inflammatory cytokines.We propose that telomere fragments released from senescent fetal cells are indicative of fetal cell aging. Based on our data, these telomere fragments cause oxidative stress associated damages to the term amniotic sac and force them to release other DAMPS, which, in turn, provide a sterile immune response that may be one of the many inflammatory signals required to initiate parturition at term.
Conductance in Co/Al2O3/Si/Al2O3 permalloy with asymmetrically doped barrier
Creators: name: Guerrero, R.
name: Aliev, F. G.
name: Villar, R.
name: Santos, T.
name: Moodera, J.
name: Dugaev, V. K.
name: Barnas, J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Permalloy magnetic tunnel junctions. Complementary low frequency noise measurements are used to understand the conductance results. The obtained data indicate the breakdown of the Coulomb blockade for thickness of the asymmetric silicon layer exceeding 1.2Å. The crossover in the conductance, the dependence of the tunnelling magnetoresistance with the bias voltage and the noise below 80K correspond to 1 monolayer coverage. Interestingly, the zero bias magnetoresistance remains nearly unaffected by the presence of the silicon layer. The proposed model uses Larkin-Matveev approximation of tunnelling through a single impurity layer generalized to 3D and takes into account the variation of the barrier shape with the bias voltage. The main difference is the localization of all the impurity levels within a single atomic layer. In the high thickness case, up to 1.8Å, we have introduced a phenomenological parameter, which reflects the number of single levels on the total density of silicon atoms.
description: 10 pages, 13 figures
Home-based neurologic music therapy for upper limb rehabilitation with stroke patients at community rehabilitation stage—a feasibility study protocol
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: ARAT
community rehabilitation
feasibility study
hemiparetic
music-supported therapy
stroke
therapeutic instrumental music performance (TIMP)

description: © 2015 Street, Magee, Odell-Miller, Bateman and Fachner. Background: Impairment of upper limb function following stroke is more common than lower limb impairment and is also more resistant to treatment. Several lab-based studies with stroke patients have produced statistically significant gains in upper limb function when using musical instrument playing and techniques where rhythm acts as an external time-keeper for the priming and timing of upper limb movements. Methods: For this feasibility study a small sample size of 14 participants (3-60 months post stroke) has been determined through clinical discussion between the researcher and study host in order to test for management, feasibility and effects, before planning a larger trial determined through power analysis. A cross-over design with five repeated measures will be used, whereby participants will be randomized into either a treatment (n = 7) or wait list control (n = 7) group. Intervention will take place twice weekly over 6 weeks. The ARAT and 9HPT will be used to measure for quantitative gains in arm function and finger dexterity, pre/post treatment interviews will serve to investigate treatment compliance and tolerance. A lab based EEG case comparison study will be undertaken to explore audio-motor coupling, brain connectivity and neural reorganization with this intervention, as evidenced in similar studies. Discussion: Before evaluating the effectiveness ofahome-based intervention in a larger scale study, it is important to assess whether implementation of the trial methodology is feasible. This study investigates the feasibility, efficacy and patient experience of a music therapy treatment protocol comprising a chart of 12 different instrumental exercises and variations, which aims at promoting measurable changes in upper limb function in hemiparetic stroke patients. The study proposes to examine several new aspects including home-based treatment and dosage, and will provide data on recruitment, adherence and variability of outcomes.
Vortex structure of a neutron star with CFL quark core
Creators: name: Sedrakian, D. M.
name: Blaschke, D.
name: Shahabasyan, K. M.
name: Shahabasyan, M. K.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Ginzburg-Landau equations for magnetic and gluomagnetic gauge fields of the semi-superfluid strings in the color superconducting core of the neutron star with diquark condensate in the color-flavor-locking (CFL) phase are derived. The simultaneous coupling of the CFL diquark condensate to the magnetic and gluomagnetic gauge fields is taken into account. The asymptotic values of these string energies are defined from quantization conditions. It is shown that a lattice of semi-superfluid strings with minimal quantum of circulation emerges in the superconducting quark core during rotation of the star. The magnetic field in the core of this string is of order of 10^18 G. The cluster of proton vortices appeared in the hadronic phase around each superfluid neutron vortex due to entrainment effect, creates in the superconducting quark core new semi-superfluid strings with minimal quantum of circulation.
description: 8 pages, minor typos corrected
Societies, Chapters, and Clubs: Oh My!
Creators: name: Hunt, Kurt Thomas
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
The distance to a star forming region in the Outer arm of the Galaxy
Creators: name: Hachisuka, K.
name: Brunthaler, A.
name: Menten, K. M.
name: Reid, M. J.
name: Hagiwara, Y.
name: Mochizuki, N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We performed astrometric observations with the VLBA of WB89-437, an H2O maser source in the Outer spiral arm of the Galaxy. We measure an annual parallax of 0.167 +/- 0.006 mas, corresponding to a heliocentric distance of 6.0 +/- 0.2 kpc or a Galactocentric distance of 13.4 +/- 0.2 kpc. This value for the heliocentric distance is considerably smaller than the kinematic distance of 8.6 kpc. This confirms the presence of a faint Outer arm toward l = 135 degrees. We also measured the full space motion of the object and find a large peculiar motion of ~20 km/s toward the Galactic center. This peculiar motion explains the large error in the kinematic distance estimate. We also find that WB89-437 has the same rotation speed as the LSR, providing more evidence for a flat rotation curve and thus the presence of dark matter in the outer Galaxy.
description: The Astrophysical Journal, accepted, 16 pages, 4 Figures
Longitudinal analysis of Plasmodium falciparum genetic variation in Turbo, Colombia: Implications for malaria control and elimination
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Malaria incidence
Plasmodium
Mutation rate
Microsatellites
Inbreeding

description: © 2015 Chenet et al. Background: Malaria programmes estimate changes in prevalence to evaluate their efficacy. In this study, parasite genetic data was used to explore how the demography of the parasite population can inform about the processes driving variation in prevalence. In particular, how changes in treatment and population movement have affected malaria prevalence in an area with seasonal malaria. Methods: Samples of Plasmodium falciparum collected over 8 years from a population in Turbo, Colombia were genotyped at nine microsatellite loci and three drug-resistance loci. These data were analysed using several population genetic methods to detect changes in parasite genetic diversity and population structure. In addition, a coalescent-based method was used to estimate substitution rates at the microsatellite loci. Results: The estimated mean microsatellite substitution rates varied between 5.35 × 10-3 and 3.77 × 10-2 substitutions/locus/month. Cluster analysis identified six distinct parasite clusters, five of which persisted for the full duration of the study. However, the frequencies of the clusters varied significantly between years, consistent with a small effective population size. Conclusions: Malaria control programmes can detect re-introductions and changes in transmission using rapidly evolving microsatellite loci. In this population, the steadily decreasing diversity and the relatively constant effective population size suggest that an increase in malaria prevalence from 2004 to 2007 was primarily driven by local rather than imported cases.
The John D. Cooper Center series: archaeoLOGIC
Creators: name: Pedersen, Jeannine
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Parenting around child snacking: Development of a theoretically-guided, empirically informed conceptual model
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Children
Diet
Snack
Snacking
Parenting
Schemas
Qualitative

description: © 2015 Davison et al. Background: Snacking contributes to excessive energy intakes in children. Yet factors shaping child snacking are virtually unstudied. This study examines food parenting practices specific to child snacking among low-income caregivers. Methods: Semi-structured interviews were conducted in English or Spanish with 60 low-income caregivers of preschool-aged children (18 non-Hispanic white, 22 African American/Black, 20 Hispanic; 92% mothers). A structured interview guide was used to solicit caregivers' definitions of snacking and strategies they use to decide what, when and how much snack their child eats. Interviews were audio-recorded, transcribed verbatim and analyzed using an iterative theory-based and grounded approach. A conceptual model of food parenting specific to child snacking was developed to summarize the findings and inform future research. Results: Caregivers' descriptions of food parenting practices specific to child snacking were consistent with previous models of food parenting developed based on expert opinion [1, 2]. A few noteworthy differences however emerged. More than half of participants mentioned permissive feeding approaches (e.g., my child is the boss when it comes to snacks). As a result, permissive feeding was included as a higher order feeding dimension in the resulting model. In addition, a number of novel feeding approaches specific to child snacking emerged including child-centered provision of snacks (i.e., responding to a child's hunger cues when making decisions about snacks), parent unilateral decision making (i.e., making decisions about a child's snacks without any input from the child), and excessive monitoring of snacks (i.e., monitoring all snacks provided to and consumed by the child). The resulting conceptual model includes four higher order feeding dimensions including autonomy support, coercive control, structure and permissiveness and 20 sub-dimensions. Conclusions: This study formulates a language around food parenting practices specific to child snacking, identifies dominant constructs, and proposes a conceptual framework to guide future research.
Archaeology of Historic Houses
Creators: name: Beisaw, April M.
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Curating a Small Archaeology Museum
Creators: name: Sedar, Dena
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Archaeology is Adventure - Even When You End up in the Office
Creators: name: Costa, Stefano
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Arbeitszufriedenheit im Kontext
Creators: name: Martin, Albert
name: Jochims, Thorsten
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2014
Subjects: subject: Arbeitszufriedenheit
classificationCode: 330
subject: 330 Wirtschaft

description: Der vorliegende Beitrag beschäftigt sich mit dem Zusammenwirken der Arbeitszufriedenheit mit wichtigen Kontextvariablen. Wir vergleichen die Wirkung der Arbeitszufriedenheit auf Rückzugstendenzen auf der einen und auf proaktive Verhaltenstendenzen auf der anderen Seite. Die zentrale These des vorliegenden Beitrags lautet, dass die Arbeitszufriedenheit eine wichtige Erklärungsvariable ist, dass sich ihre Erklärungskraft allerdings deutlich verbessert, wenn man sie im Kontext von weiteren Variablen betrachtet. In unserer empirischen Analyse gehen wir auf eine Reihe von wichtigen Kontextvariablen ein und zeigen deren Bedeutung für das Wirksamwerden der Arbeitszufriedenheit auf.
Central values of derivatives of Dirichlet L-functions
Creators: name: Bui, H. M.
name: Milinovich, M. B.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11M06, 11M26

description: Let C(q,+) be the set of even, primitive Dirichlet characters (mod q). Using the mollifier method we show that L^{(k)}(1/2,chi) is not equal to zero for almost all the characters chi in C(q,+) when k and q are large. Here, L^{(k)}(s,chi) is the k-th derivative of of the Dirichlet L-function L(s,chi).
description: submitted for publication
Plots, Papers and Reports, Oh My!
Creators: name: Armstrong, Kayt
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Estimation of a biofilm-specific reaction rate: Kinetics of bacterial urea hydrolysis in a biofilm
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: 0605 Microbiology
Infection

description: © 2015 Nanyang Technological University/Macmillan Publishers Limited. BACKGROUND/OBJECTIVES: Biofilms and specifically urea-hydrolysing biofilms are of interest to the medical community (for example, urinary tract infections), scientists and engineers (for example, microbially induced carbonate precipitation). To appropriately model these systems, biofilm-specific reaction rates are required. A simple method for determining biofilm-specific reaction rates is described and applied to a urea-hydrolysing biofilm. METHODS: Biofilms were grown in small silicon tubes and influent and effluent urea concentrations were determined. Immediately after sampling, the tubes were thin sectioned to estimate the biofilm thickness profile along the length of the tube. Urea concentration and biofilm thickness data were used to construct an inverse model for the estimation of the urea hydrolysis rate. RESULTS/CONCLUSIONS: It was found that urea hydrolysis in Escherichia coli MJK2 biofilms is well approximated by first-order kinetics between urea concentrations of 0.003 and 0.221 mol/l (0.186 and 13.3 g/l). The first-order rate coefficient (k1) was estimated to be 23.2 ± 6.2 h-1. It was also determined that advection dominated the experimental system rather than diffusion, and that urea hydrolysis within the biofilms was not limited by diffusive transport. Beyond the specific urea-hydrolysing biofilm discussed in this work, the method has the potential for wide application in cases where biofilm-specific rates must be determined.
A mathematical study of the hematopoiesis process with applications to chronic myelogenous leukemia
Creators: name: Adimy, Mostafa
name: Crauste, Fabien
name: Ruan, Shigui
Publisher: name: arXiv
Year: 2009
Subjects: subject: Analysis of PDEs (math.AP)
subject: Cell Behavior (q-bio.CB)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Mathematics
subject: FOS: Biological sciences

description: This paper is devoted to the analysis of a mathematical model of blood cells production in the bone marrow (hematopoiesis). The model is a system of two age-structured partial differential equations. Integrating these equations over the age, we obtain a system of two nonlinear differential equations with distributed time delay corresponding to the cell cycle duration. This system describes the evolution of the total cell populations. By constructing a Lyapunov functional, it is shown that the trivial equilibrium is globally asymptotically stable if it is the only equilibrium. It is also shown that the nontrivial equilibrium, the most biologically meaningful one, can become unstable via a Hopf bifurcation. Numerical simulations are carried out to illustrate the analytical results. The study maybe helpful in understanding the connection between the relatively short cell cycle durations and the relatively long periods of peripheral cell oscillations in some periodic hematological diseases.
Concept & form : post-philosophical studies in contemporary art
Creators: name: Wear, AP
Publisher: name: University Of Tasmania
Year: 2023

description: This thesis identifies a problem within current philosophical perspectives concerning contemporary visual art, namely, the underestimation of the unique qualities of a concept in visual form. There is a related deficit in the literature about both the practice of contemporary art making as a cognitive manipulation of concept and form, and the ways in which the viewer might dissect the relationship between concept and form in philosophical inquiry. This thesis explores two central claims. First, that visual art allows for a spatial and temporal conflation of concept that manufactures a unique philosophical realm more readily cognitively assimilated than with the written or spoken word. Second, that a post-philosophical reading of some contemporary art works is possible whereby both pursuits might inform each other, forging expanded potential in inquiry. The thesis takes the form of detailed case studies of single works of art and their relationship with particular models/instances/paradigms of philosophical thinking. Presenting select works of art by Joseph Beuys, Anselm Kiefer and Hanne Darboven, the thesis explores how this range of contemporary works of art engage concurrently produced works of philosophy. This thesis ends with the author's personal account of the cognitive manipulation of concept and form as an insight into the creation of a work of art. The thesis submits that a greater understanding of contemporary art practice - from conception to exhibition - can vitalize philosophical inquiry by illuminating the cognitive process beyond written and spoken language. Scope for further research might incorporate questions concerning the emancipatory qualities of a more accessible philosophical realm, particularly concerning pedagogical or political engagement with visual representation. Such research would necessitate ongoing attention to the method and practice of 'readmg' visual representation.
Archaeology Doesn t End in the Lab, It s Got an Office Too
Creators: name: Head, Serra
Publisher: name: Archaeology Data Service
Year: 2012

description: This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by recording their day and sharing it through text, images or video on the Day of Archaeology blog.
The project asked anyone with a personal, professional or voluntary interest in archaeology to get involved, and help highlight the reasons why archaeology is vital to protect the past and inform our futures. The resulting Day of Archaeology project archive demonstrates the wide variety of work the archaeological profession undertakes day-to-day across the globe, and helps to raise public awareness of the relevance and importance of archaeology to the modern world.
The first ever Day of Archaeology was held in 2011 and, since then, the project had thousands of archaeologists take part in the event, from those working in the field through to specialists working in laboratories and behind computers. The last Day of Archaeology was on Friday 28th July 2017.
Pseudogap, non-Fermi-liquid behavior, and particle-hole asymmetry in the 2D Hubbard model
Creators: name: Liebsch, Ansgar
name: Tong, Ning-Hua
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The effect of doping in the two-dimensional Hubbard model is studied within finite temperature exact diagonalization combined with cluster dynamical mean field theory. By employing a mixed basis involving cluster sites and bath molecular orbitals for the projection of the lattice Green's function onto 2x2 clusters, a considerably more accurate description of the low frequency properties of the self-energy is achieved than in a pure site picture. The transition from Fermi-liquid to non-Fermi-liquid behavior for decreasing hole doping is studied as a function of Coulomb energy, next-nearest neighbor hopping, and temperature. In particular, the self-energy component Sigma_X associated with X=(pi,0) is shown to exhibit an onset of non-Fermi-liquid behavior as the hole doping decreases below a critical value delta_c. The imaginary part of Sigma_X(omega) then develops a collective mode above E_F, which exhibits a distinct dispersion with doping. Accordingly, the real part of Sigma_X(omega) has a positive slope above E_F, giving rise to an increasing particle-hole asymmetry as the system approaches the Mott transition. This behavior is consistent with the removal of spectral weight from electron states close to E_F and the opening of a pseudogap which increases with decreasing doping. The phase diagram reveals that delta_c = 0.15 ... 0.20 for various system parameters. For electron doping, the collective mode of Sigma_X(omega) and the concomitant pseudogap are located below the Fermi energy which is consistent the removal of spectral weight from hole states just below E_F. The critical doping which marks the onset of non-Fermi-liquid behavior, is systematically smaller than for hole doping.
description: 18 pages, 21 figures
Use of attribute association error probability estimates to evaluate quality of medical record geocodes
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Record linkage
Health informatics
Biostatistics
Geocoding
Probability
Attribute association
Attribute association error probability
Attribute association hierarchy

description: © 2015 Klaus et al. Background: The utility of patient attributes associated with the spatiotemporal analysis of medical records lies not just in their values but also the strength of association between them. Estimating the extent to which a hierarchy of conditional probability exists between patient attribute associations such as patient identifying fields, patient and date of diagnosis, and patient and address at diagnosis is fundamental to estimating the strength of association between patient and geocode, and patient and enumeration area. We propose a hierarchy for the attribute associations within medical records that enable spatiotemporal relationships. We also present a set of metrics that store attribute association error probability (AAEP), to estimate error probability for all attribute associations upon which certainty in a patient geocode depends. Methods: A series of experiments were undertaken to understand how error estimation could be operationalized within health data and what levels of AAEP in real data reveal themselves using these methods. Specifically, the goals of this evaluation were to (1) assess if the concept of our error assessment techniques could be implemented by a population-based cancer registry; (2) apply the techniques to real data from a large health data agency and characterize the observed levels of AAEP; and (3) demonstrate how detected AAEP might impact spatiotemporal health research. Results: We present an evaluation of AAEP metrics generated for cancer cases in a North Carolina county. We show examples of how we estimated AAEP for selected attribute associations and circumstances. We demonstrate the distribution of AAEP in our case sample across attribute associations, and demonstrate ways in which disease registry specific operations influence the prevalence of AAEP estimates for specific attribute associations. Conclusions: The effort to detect and store estimates of AAEP is worthwhile because of the increase in confidence fostered by the attribute association level approach to the assessment of uncertainty in patient geocodes, relative to existing geocoding related uncertainty metrics.
Euchromiina Butler 1876
Creators: name: Landry, Bernard
name: Léger, Théo
name: Nuss, Matthias
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae

description: 1. The family-group name EUCHROMIINAE (Lepidoptera, EREBIDAE Leach, 1815) was established by Butler (1876: 361)
based on the genus Euchromia Hübner, 1819 (in Hübner, 1816: 121).
The name was subsequently used as EUCHROMIINI, a tribe in the ARCTIIDAE (e.g. Fibiger & Lafontaine, 2005; Cerda, 2008; Vives Moreno, 2019) and, following the transfer of ARCTIIDAE to EREBIDAE, as a subfamily (e.g. Zahiri et al., 2011).
It is now used as the subtribe EUCHROMIINA
of the tribe ARCTIINI (Lafontaine & Schmidt, 2010).
description: Published as part of Landry, Bernard, Léger, Théo & Nuss, Matthias, 2020, Case 3819 - Euchromiini Léger, Landry & amp; Nuss, 2019 (Insecta, Lepidoptera, Crambidae) and Euchromiinae Butler, 1876 (Insecta, Lepidoptera, Erebidae): proposed resolution of homonymy by emending the former to Euchromiusini, pp. 83 in Bulletin of Zoological Nomenclature 77 (1) on page 83, DOI: 10.21805/bzn.v77.a027, http://zenodo.org/record/15085591
Assigning and visualizing germline genes in antibody repertoires
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: immunoglobulin
V(D)J rearrangements
phylogenetic models
classification
visualization
IgSCUEAL

description: © 2015 The Author(s) Published by the Royal Society. All rights reserved. Identifying the germline genes involved in immunoglobulin rearrangements is an essential first step in the analysis of antibody repertoires. Based on our prior work in analysing diverse recombinant viruses, we present IgSCUEAL (Immunoglobulin Subtype Classification Using Evolutionary ALgorithms), a phylogenetic approach to assign V and J regions of immunoglobulin sequences to their corresponding germline alleles, with D regions assigned using a simple pairwise alignment algorithm. We also develop an interactive web application for viewing the results, allowing the user to explore the frequency distribution of sequence assignments and CDR3 region length statistics, which is useful for summarizing repertoires, aswell as a detailed viewer of rearrangements and region alignments for individual query sequences.We demonstrate the accuracy and utility of our method compared with sequence similarity-based approaches and other non-phylogenetic model-based approaches, using both simulated data and a set of evaluation datasets of human immunoglobulin heavy chain sequences. IgSCUEAL demonstrates the highest accuracy of V and J assignment amongst existing approaches, even when the reassorted sequence is highly mutated, and can successfully cluster sequences on the basis of shared V/J germline alleles.
Transport of free surface liquid films and drops by external ratchets and self-ratcheting mechanisms
Creators: name: Thiele, Uwe
name: John, Karin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We discuss the usage of ratchet mechanisms to transport a continuous phase in several micro-fluidic settings. In particular, we study the transport of a dielectric liquid in a heterogeneous ratchet capacitor that is periodically switched on and off. The second system consists of drops on a solid substrate that are transported by different types of harmonic substrate vibrations. We argue that the latter can be seen as a self-ratcheting process and discuss analogies between the employed class of thin film equations and Fokker-Planck equations for transport of discrete objects in a 'particle ratchet'.
description: 10 pages, 13 figures
Constructing optimal experience for the hospitalized newborn through neuro-based music therapy
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: neonatal intensive care unit
music therapy
preterm infant
auditory environment
stimulation
family centered practice

description: © 2015 Shoemark, Hanson-Abromeit and Stewart. Music-based intervention for hospitalized newborn infants has traditionally been based in a biomedical model, with physiological stability as the prime objective. More recent applications are grounded in other theories, including attachment, trauma and neurological models in which infant, parent and the dyadic interaction may be viewed as a dynamic system bound by the common context of the neonatal intensive care unit (NICU). The immature state of the preterm infant’s auditory processing system requires a careful and individualized approach for the introduction of purposeful auditory experience intended to support development. The infant’s experience of an unpredictable auditory environment is further compromised by a potential lack of meaningful auditory stimulation. Parents often feel disconnected from their own capacities to nurture their infant with potentially life-long implications for the infant’s neurobehavioral and psychological well-being. This perspectives paper will outline some neurological considerations for auditory processing in the premature infant to frame a premise for music-based interventions. A hypothetical clinical case will illustrate the application of music by a music therapist with an infant and family in NICU.
An operational framework relating generic activity patterns in the residential open space environment to physical design
Creators: name: Heuer, Harry
Publisher: name: University of British Columbia
Year: 2011

description: Behavioral research is providing meaningful information with respect to the relationship between human activities and physical design of the residential environment. While the appeal among professions and social scientists for its input into the design process seems unanimous, the failure to pool, simplify and constantly update such data, continues in it being accessible to, and usable by, only a small, enlightened and privileged minority. On the other hand, a large share of today's housing in Canada is produced by individuals and organizations, many of whom are generally familiar and concerned with neither human behavior nor basic design principles. Resultant projects invariably betray an almost single-minded approach, that of realizing a maximum number of dwellings at a minimum expenditure on amenities. This study attempts to narrow the gap between the researcher and the practitioner. It proposes a communicable, organized approach to designing and evaluating physical components in the residential open space environment, as to their responsiveness to generic human activities. A Frame of Reference (activities and components) is developed, which generates the context and the problem for Patterns, which, in turn, suggest solutions or platforms for discussion. The principle evolved, is then applied to site plans of three recently completed housing projects. Variables, in this model, include age of users and climate of the location. The benefits of this approach, include prevention of the worst of open space planning, while encouraging good work to proceed. Avenues for implementing such a process are briefly explored and its application, by money-lending agencies, held as feasible.