cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons
Creators: name: Janach, Gabriel M. S.
name: Reetz, Olivia
name: Döhne, Noah
name: Stadler, Konstantin
name: Grosser, Sabine
name: Byvaltcev, Egor
name: Bräuer, Anja U.
name: Strauss, Ulf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: IFN
subject: Neocortical neurons
subject: Interferon receptor
subject: HCN
subject: Neuromodulation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in several brain regions. Previously, we have shown that raising levels of IFN-β (a type I IFN) lead to increased neuronal excitability of neocortical layer 5 pyramidal neurons. Because of shared non-canonical signaling pathways of both cytokines, we hypothesized a similar neocortical role of acutely applied IFN-γ. METHODS: We used semi-quantitative RT-PCR, immunoblotting, and immunohistochemistry to analyze neuronal expression of IFN-γ receptors and performed whole-cell patch-clamp recordings in layer 5 pyramidal neurons to investigate sub- and suprathreshold excitability, properties of hyperpolarization-activated cyclic nucleotide-gated current (Ih), and inhibitory neurotransmission under the influence of acutely applied IFN-γ. RESULTS: We show that IFN-γ receptors are present in the membrane of rat's neocortical layer 5 pyramidal neurons. As expected from this and the putative overlap in IFN type I and II alternative signaling pathways, IFN-γ diminished Ih, mirroring the effect of type I IFNs, suggesting a likewise activation of protein kinase C (PKC). In contrast, IFN-γ did neither alter subthreshold nor suprathreshold neuronal excitability, pointing to augmented inhibitory transmission by IFN-γ. Indeed, IFN-γ increased electrically evoked inhibitory postsynaptic currents (IPSCs) on neocortical layer 5 pyramidal neurons. Furthermore, amplitudes of spontaneous IPSCs and miniature IPSCs were elevated by IFN-γ, whereas their frequency remained unchanged. CONCLUSIONS: The expression of IFN-γ receptors on layer 5 neocortical pyramidal neurons together with the acute augmentation of inhibition in the neocortex by direct application of IFN-γ highlights an additional interaction between the CNS and immune system. Our results strengthen our understanding of the role of IFN-γ in neocortical neurotransmission and emphasize its impact beyond its immunological properties, particularly in the pathogenesis of neuropsychiatric disorders.
Discovery of a Clustered Quasar Pair at z ~ 5: Biased Peaks in Early Structure Formation
Creators: name: Djorgovski, S. G.
name: Stern, D.
name: Mahabal, A.
name: Brunner, R.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report a discovery of a quasar at z = 4.96 +- 0.03 within a few Mpc of the quasar SDSS 0338+0021 at z = 5.02 +- 0.02. The newly found quasar has the SDSS i and z magnitudes of ~ 21.2, and an estimated absolute magnitude M_B ~ -25.2. The projected separation on the sky is 196 arcsec, and the redshift difference Delta z = 0.063 +- 0.008. The probability of finding this quasar pair by chance in the absence of clustering in this particular volume is ~ 10^-4 to 10^-3. We conclude that the two objects probably mark a large-scale structure, possibly a protocluster, at z ~ 5. This is the most distant such structure currently known. Our search in the field of 13 other QSOs at z >~ 4.8 so far has not resulted in any detections of comparable luminous QSO pairs, and it is thus not yet clear how representative is this structure at z ~ 5. However, along with the other evidence for clustering of quasars and young galaxies at somewhat lower redshifts, the observations are at least qualitatively consistent with a strong biasing of the first luminous and massive objects, in agreement with general predictions of theoretical models. More extensive searches for clustered quasars and luminous galaxies at these redshifts will provide valuable empirical constraints for our understanding of early galaxy and structure formation.
description: Latex file, 8 pages, 3 eps figures, sty files included. To appear in the ApJ
Approximative treatment of 5f-systems with partial localization due to intra-atomic correlations
Creators: name: Runge, E.
name: Fulde, P.
name: Efremov, D. V.
name: Hasselmann, N.
name: Zwicknagl, G.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Increasing experimental and theoretical evidence points towards a dual nature of the 5$f$ electrons in actinide-based strongly correlated metallic compounds, with some 5$f$ electrons being localized and others delocalized. In a recent paper (PRB xxx, 2004), we suggested the interplay of intra-atomic correlations as described by Hund's rules and a weakly anisotropic hopping (hybridization) as a possible mechanism. The purpose of the present work is to provide a first step towards a microscopic description of partial localization in solids by analyzing how well various approximation schemes perform when applied to small clusters. It is found that many aspects of partial localization are described appropriately both by a variational wavefunction of Gutzwiller type and by a treatment which keeps only those interactions which are present in LDA+U calculations. In contrast, the energies and phase diagram calculated within the Hartree Fock approximation show little resemblence with the exact results. Enhancement of hopping anisotropy by Hund's rule correlations are found in all approximations.
description: 9 pages, 9 figures
Cheumatopsyche digitata
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche digitata

description: 15. Cheumatopsyche digitata species group
 The species in this group are characterized by having a short segment X, with elongated, almost filiform, setose pair of apicoventral lobes (Fig. 15), or with a group of lobes. One species, C. simplex Kimmins from Ethiopia, has a reduced, very short segment X and no apicoventral setal lobes. The short segment X is accompanied by reduction of the apicoventral setal lobes, forming a pair of short setose processes or setose warts. This species group is morphologically close to other groups characterized by presence of a bilobed segment X. The C. digitata species group is separated from the groups having bilobed segment X by presence of a pair of much longer apicoventral setal lobes, and the shortened segment X; and the pair of wart-like, lateral setose areas are located distally on segment X. This species group is restricted to the Afrotropical region except C. thaba Mosely from Yemen and C. ernestheissi Malicky from Brunei.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 155
An intense soft-excess and evidence for light bending in the luminous narrow-line quasar PHL 1092
Creators: name: Gallo, L. C.
name: Boller, Th.
name: Brandt, W. N.
name: Fabian, A. C.
name: Grupe, D.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The narrow-line quasar PHL 1092 was observed by XMM-Newton at two epochs separated by nearly thirty months. Timing analyses confirm the extreme variability observed during previous X-ray missions. A measurement of the radiative efficiency is in excess of what is expected from a Schwarzschild black hole. In addition to the rapid X-ray variability, the short UV light curves (< 4 hours) obtained with the Optical Monitor may also show fluctuations, albeit at much lower amplitude than the X-rays. In general, the extreme variability is impressive considering that the broad-band (0.4-10 keV rest-frame) luminosity of the source is ~10^45 erg/s. During at least one of the observations, the X-ray and UV light curves show common trends, although given the short duration of the OM observations, and low significance of the UV light curves it is difficult to comment on the importance of this possible correlation. Interestingly, the high-energy photons (> 2 keV) do not appear highly variable. The X-ray spectrum resembles that of many narrow-line Seyfert 1 type galaxies: an intense soft-excess modelled with a multi-colour disc blackbody, a power-law component, and an absorption line at ~1.4 keV. The ~1.4 keV feature is curious given that it was not detected in previous observations, and its presence could be related to the strength of the soft-excess. Of further interest is curvature in the spectrum above ~2 keV which can be described by a strong reflection component. The strong reflection component, lack of high-energy temporal variability, and extreme radiative efficiency measurements can be understood if we consider gravitational light bending effects close to a maximally rotating black hole.
description: To appear in MNRAS. Submitted March 01, 2004. 9 pages
Bargaining with entropy and energy
Creators: name: Babajanyan, S. G.
name: Cheong, K. H.
name: Allahverdyan, A. E.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computer Science and Game Theory (cs.GT)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Statistical mechanics is based on interplay between energy minimization and entropy maximization. Here we formalize this interplay via axioms of cooperative game theory (Nash bargaining) and apply it out of equilibrium. These axioms capture basic notions related to joint maximization of entropy and minus energy, formally represented by utilities of two different players. We predict thermalization of a non-equilibrium statistical system employing the axiom of affine covariance|related to the freedom of changing initial points and dimensions for entropy and energy|together with the contraction invariance of the entropy-energy diagram. Whenever the initial non-equilibrium state is active, this mechanism allows thermalization to negative temperatures. Demanding a symmetry between players fixes the final state to a specific positive-temperature (equilibrium) state. The approach solves an important open problem in the maximum entropy inference principle, {\it viz.} generalizes it to the case when the constraint is not known precisely.
description: 4+6 pages, 5 figures, 1 table
Cheumatopsyche antoniensis Malicky 1982
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche antoniensis

description: Cheumatopsyche antoniensis Malicky, 1982
 Cheumatopsyche antoniensis Malicky, 1982: 107.
 Type locality: Cape Verde Islands.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 155
Identifying predictive features of autism spectrum disorders in a clinical sample of adolescents and adults using machine learning
Creators: name: Küpper, Charlotte
name: Stroth, Sanna
name: Wolff, Nicole
name: Hauck, Florian
name: Kliewer, Natalie
name: Schad-Hansjosten, Tanja
name: Kamp-Becker, Inge
name: Poustka, Luise
name: Roessner, Veit
name: Schultebraucks, Katharina
name: Roepke, Stefan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: autism
subject: machine learning
subject: ADOS
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Diagnosing autism spectrum disorders (ASD) is a complicated, time-consuming process which is particularly challenging in older individuals. One of the most widely used behavioral diagnostic tools is the Autism Diagnostic Observation Schedule (ADOS). Previous work using machine learning techniques suggested that ASD detection in children can be achieved with substantially fewer items than the original ADOS. Here, we expand on this work with a specific focus on adolescents and adults as assessed with the ADOS Module 4. We used a machine learning algorithm (support vector machine) to examine whether ASD detection can be improved by identifying a subset of behavioral features from the ADOS Module 4 in a routine clinical sample of N = 673 high-functioning adolescents and adults with ASD (n = 385) and individuals with suspected ASD but other best-estimate or no psychiatric diagnoses (n = 288). We identified reduced subsets of 5 behavioral features for the whole sample as well as age subgroups (adolescents vs. adults) that showed good specificity and sensitivity and reached performance close to that of the existing ADOS algorithm and the full ADOS, with no significant differences in overall performance. These results may help to improve the complicated diagnostic process of ASD by encouraging future efforts to develop novel diagnostic instruments for ASD detection based on the identified constructs as well as aiding clinicians in the difficult question of differential diagnosis.
Development and Assessment of Nano-Technologies for Cancer Treatment: Cytotoxicity and Hyperthermia Laboratory Studies
Creators: name: Medina-Ramírez, Iliana E.
name: Olmos, María Alejandra Díaz De León
name: Ortega, Martín Humberto Muñoz
name: Zapien, Juan Antonio
name: Betancourt, Israel
name: Santoyo-Elvira, Nathaly
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Cancer treatment by magnetic hyperthermia offers numerous advantages, but for practical applications many variables still need to be adjusted before developing a controlled and reproducible cancer treatment that is bio-compatible (non-damaging) to healthy cells. In this work, Fe3O4 and CoFe2O4 were synthesized and systematically studied for the development of efficient therapeutic agents for applications in hyperthermia. The biocompatibility of the materials was further evaluated using HepG2 cells as biological model. Colorimetric and microscopic techniques were used to evaluate the interaction of magnetic nano-materials (MNMs) and HepG2 cells. Finally, the behavior of MNMs was evaluated under the influence of an alternating magnetic field (AMF), observing a more efficient temperature increment for CoFe2O4, a desirable behavior for biomedical applications since lower doses and shorter expositions to alternating magnetic field might be required.
Cheumatopsyche digitata
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche digitata

description: Cheumatopsyche digitata (Mosely, 1935)
 Hydropsychodes digitata Mosely, 1935: 228.
 Cheumatopsyche digitata (Mosely, 1935); Kimmins 1963: 130.
 Type locality: Zaire, not Tanganyika.
 New record: GHANA: Kumasi, 5–6.vi.1965, light [S. Endrödy] — 1 male (HNHM, in alcohol); GHANA: Kumasi, 18.v.1967, light [S. Endrödy] — 1 male (HNHM, in alcohol); GHANA: Kumasi, 25.v.1967, light [S. Endrödy] — 6 males (HNHM, in alcohol); GHANA: Kumasi, 3.vi.1967, light [S. Endrödy] — 21 males (HNHM, in alcohol); GHANA: Kumasi, 15.ix.1967, light [S. Endrödy] — 5 males (OPC, in alcohol); GHANA: Kumasi, 28.ix.1967, light [S. Endrödy] — 7 males (HNHM, in alcohol); GHANA: Bobiri Forest Reserve, 6.iii.1967, light [S. Endrödy] ― 1 male (HNHM, in alcohol); GHANA: Kwadaso, 4.iii.1969, light [S. Endrödy] — 1 male (HNHM, in alcohol).
 Distribution: Central and West Africa, including islands.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on pages 155-156
Coronae & Outflows from Helical Dynamos, Compatibility with the MRI, and Application to Protostellar Disks
Creators: name: Blackman, Eric G.
name: Tan, Jonathan C.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Magnetically mediated disk outflows are a leading paradigm to explain winds and jets in a variety of astrophysical sources, but where do the fields come from? Since accretion of mean magnetic flux may be disfavored in a thin turbulent disk, and only fields generated with sufficiently large scale can escape before being shredded by turbulence, in situ field production is desirable. Nonlinear helical inverse dynamo theory can provide the desired fields for coronae and outflows. We discuss the implications for contemporary protostellar disks, where the MRI (magneto-rotational instability) can drive turbulence in the inner regions, and primordial protostellar disks, where gravitational instability drives the turbulence. We emphasize that helical dynamos are compatible with the magneto-rotational instability, and clarify the relationship between the two.
description: 12 pages, LaTeX (with figs); version in press for "Proceedings of the International Workshop on Magnetic Fields and Star Formation: Theory vs. Observation" Madrid, Spain; April 2003
Dynamic Rashba-Dresselhaus Effect
Creators: name: Schlipf, Martin
name: Giustino, Feliciano
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The Rashba-Dresselhaus effect is the splitting of doubly degenerate band extrema in semiconductors, accompanied by the emergence of counter-rotating spin textures and spin-momentum locking. Here we investigate how this effect is modified by lattice vibrations. We show that, in centrosymmetric non-magnetic crystals, for which a bulk Rashba-Dresselhaus effect is symmetry-forbidden, electron-phonon interactions can induce a phonon-assisted, dynamic Rashba-Dresselhaus spin splitting in the presence of an out-of-equilibrium phonon population. In particular, we show how Rashba, Dresselhaus, or Weyl spin textures can selectively be established by driving coherent infrared-active phonons, and we perform ab initio calculations to quantify this effect for halide perovskites.
Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis
Creators: name: Czabanka, Marcus
name: Petrilli, Lucia Lisa
name: Elvers-Hornung, Susanne
name: Bieback, Karen
name: Imhof, Beat Albert
name: Vajkoczy, Peter
name: Vinci, Maria
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: JAM-C
subject: endothelial progenitors
subject: adhesion
subject: migration
subject: tumor angiogenesis
subject: perivascular niche
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The homing of Endothelial Progenitor Cells (EPCs) to tumor angiogenic sites has been described as a multistep process, involving adhesion, migration, incorporation and sprouting, for which the underlying molecular and cellular mechanisms are yet to be fully defined. Here, we studied the expression of Junctional Adhesion Molecule-C (JAM-C) by EPCs and its role in EPC homing to tumor angiogenic vessels. For this, we used mouse embryonic-Endothelial Progenitor Cells (e-EPCs), intravital multi-fluorescence microscopy techniques and the dorsal skin-fold chamber model. JAM-C was found to be expressed by e-EPCs and endothelial cells. Blocking JAM-C did not affect adhesion of e-EPCs to endothelial monolayers in vitro but, interestingly, it did reduce their adhesion to tumor endothelium in vivo. The most striking effect of JAM-C blocking was on tube formation on matrigel in vitro and the incorporation and sprouting of e-EPCs to tumor endothelium in vivo. Our results demonstrate that JAM-C mediates e-EPC recruitment to tumor angiogenic sites, i.e., coordinated homing of EPCs to the perivascular niche, where they cluster and interact with tumor blood vessels. This suggests that JAM-C plays a critical role in the process of vascular assembly and may represent a potential therapeutic target to control tumor angiogenesis.
"Nano-ghosts": risk assessment of submicron-sized particles in food biased towards fictional "nano"
Creators: name: Naegeli, Hanspeter
name: Gsell, Corina
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2022
Subjects: food additive
titanium dioxide
micron-sized particles
aggregate
agglomerate

description: Much confusion has been generated in the safety assessment of food-grade TiO2 (E171) by the comingling of studies conducted on submicron-sized particles with those examining the toxicity of more minuscule counterparts. As E171 displays a nano-sized tail in its particle distribution (up to 36 % of particles with a diameter < 100 nm), it was thought that potential hazards of this food additive can be extrapolated from studies on thoroughly nanoscale formulations. This simplistic procedure may, however, overestimate the effects of the nano-sized tail of E171 because TiO2 particles readily aggregate or agglomerate in aqueous suspensions and biological matrices. The resulting larger clusters display a reduced oral bioavailability in comparison to the same material in nano-sized dimensions. Also, even if taken up in trace amounts, the smaller particles likely remain appended to larger particles or clusters and these aggregates or conglomerates may nullify to a great extent their “nano” characteristics. The purpose of this review is, therefore, to reevaluate the literature on the toxicity of TiO2 particles focusing on studies that are directly relevant for the assessment of E171. The purpose is not to avert a ban on the use of E171 in food, which might well be justified in light of the uncertainties associated with this additive employed solely for its colorant properties. Instead, it will be important to avoid in the future this same bias towards a fictional “nano” hazard, especially when evaluating more innovative engineered particles that confer true benefits for example by enhancing nutritional properties, quality, freshness, traceability or sustainability of food.
description: EXCLI Journal; 21:Doc279; ISSN 1611-2156
Factorizations of some weighted spanning tree enumerators
Creators: name: Martin, Jeremy L.
name: Reiner, Victor
Publisher: name: arXiv
Year: 2003
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C05 (Primary)

description: We give factorizations for weighted spanning tree enumerators of Cartesian products of complete graphs, keeping track of fine weights related to degree sequences and edge directions. Our methods combine Kirchhoff's Matrix-Tree Theorem with the technique of identification of factors.
description: Final version, 12 pages. To appear in the Journal of Combinatorial Theory, Series A. The paper has been reorganized, and the proof of Theorem 4 shortened, in light of a more general result appearing in reference [6]
Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing
Creators: name: Gaber, Timo
name: Brinkman, Antonia Clara Katharina
name: Pienczikowski, Justyna
name: Diesing, Karoline
name: Damerau, Alexandra
name: Pfeiffenberger, Moritz
name: Lang, Annemarie
name: Ohrndorf, Sarah
name: Burmester, Gerd-Rüdiger
name: Buttgereit, Frank
name: Hoff, Paula
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: bone healing
subject: tofacitinib
subject: hMSC-migration
subject: chondrogenic differentiation
subject: osteogenic differentiation
subject: osteoclast differentiation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing. Janus kinase (JAK) inhibition with tofacitinib has been demonstrated to act as a potent anti-inflammatory therapeutic agent in the treatment of RA, but its impact on the fundamental processes of bone regeneration is currently controversially discussed and at least in part elusive. Therefore, in this study, we aimed to examine the effects of tofacitinib on processes of bone healing focusing on recruitment of human mesenchymal stromal cells (hMSCs) into the inflammatory microenvironment of the fracture gap, chondrogenesis, osteogenesis and osteoclastogenesis. We performed our analyses under conditions of reduced oxygen availability in order to mimic the in vivo situation of the fracture gap most optimal. We demonstrate that tofacitinib dose-dependently promotes the recruitment of hMSCs under hypoxia but inhibits recruitment of hMSCs under normoxia. With regard to the chondrogenic differentiation of hMSCs, we demonstrate that tofacitinib does not inhibit survival at therapeutically relevant doses of 10-100 nM. Moreover, tofacitinib dose-dependently enhances osteogenic differentiation of hMSCs and reduces osteoclast differentiation and activity. We conclude from our data that tofacitinib may influence bone healing by promotion of hMSC recruitment into the hypoxic microenvironment of the fracture gap but does not interfere with the cartilaginous phase of the soft callus phase of fracture healing process. We assume that tofacitinib may promote bone formation and reduce bone resorption, which could in part explain the positive impact of tofacitinib on bone erosions in RA. Thus, we hypothesize that it will be unnecessary to stop this medication in case of fracture and suggest that positive effects on osteoporosis are likely.
Additional file 1 of ZNF384–ZEB1 feedback loop regulates breast cancer metastasis
Creators: name: Meng, Qing-Xiang
name: Wang, Ke-Nie
name: Li, Jun-Hui
name: Zhang, Hui
name: Chen, Zhao-Hui
name: Zhou, Xue-Jie
name: Cao, Xu-Chen
name: Wang, Ping
name: Yu, Yue
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Additional file 1: Table S1. Oligonucleotides of miRNAs and siRNAs. Table S2. Oligonucleotides used for RT-qPCR. Table S3. Antibodies used for study. Table S4. Oligonucleotides used for ChIP and methylation specific PCR.
Deficits in pain medication in older adults with chronic pain receiving home care: A cross-sectional study in Germany
Creators: name: Schneider, Juliana
name: Algharably, Engi
name: Budnick, Andrea
name: Wenzel, Arlett
name: Dräger, Dagmar
name: Kreutz, Reinhold
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: older adults
subject: home care
subject: pain medication
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: OBJECTIVE: To analyze the pattern and appropriateness of pain medications in older adults receiving home care. METHODS: We performed a prospective cross-sectional study in patients ≥65 years old having chronic pain and receiving home care in Berlin, Germany. Data on prescribed pain medications were collected using self-reported information, nursing documents, and medication plans during interviews at home. Pain intensity was determined with the numeric rating scale (NRS) and the Pain Assessment In Advanced dementia (PAINAD) scale. The Pain Medication Appropriateness Scale score (SPMAS) was applied to evaluate inappropriateness (i.e. a score ≤67) of pain medication. RESULTS: Overall 322 patients with a mean age of 82.1 ± 7.4 years (71.4% females) were evaluated. The average pain intensity scores during the last 24 hours were 5.3 ± 2.1 and 2.3 ± 2.3 on NRS and PAINAD scale (range 0-10, respectively). Sixty (18.6%) patients did not receive any pain medication. Among the treated patients, dipyrone was the most frequently prescribed analgesic (71.4%), while 50.8% and 19.1% received systemic treatment with opioids and non-steroidal anti-inflammatory drugs, respectively. The observed median SPMAS was 47.6 (range 0-100) with 58 (18.0%) of patients achieving appropriate values. Half of the patients were treated with scheduled, while 29.9% were only treated with on-demand medications. Cognitive status had no effect on appropriateness of pain treatment. CONCLUSIONS: We observed substantial deficits in dosing patterns and appropriateness of pain medication in older adults with pain receiving home care. This applied to both patients with and without severe cognitive impairment.
Willowsia platani
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Entomobryidae
Willowsia
Willowsia platani

description: Willowsia platani (Nicolet, 1842) *
Degeeria platani Nicolet, 1842: 72.
Podura argenteo-cincta Bourlet, 1843: 28.
Willowsia platani – Denis 1924d: 262.
DISTRIBUTION. — France. Bourlet 1841 (P. argenteo-cincta).
Haute-Garonne. Forêtde Bouconne (Cassagnau & Delamare Deboutteville 1951). — Gar-Cagire près de Saint-Gaudens (Salmon etal. 2010).
Haute-Saône, Savoie, Côte-d’Or. Fontaines-les-Dijon (Denis 1924d).
Hérault. Béziers (Denis 1923b, n. var, platanoÏdes).
Sud-Ouestdela France. Cassagnau 1961.
Tarn, Aude. Montagne Noire (Cassagnau 1965).
Tarn. Sidobre (Izarra 1969).
ÉCOLOGIE. — Cassagnau 1965 (écologie, sol); Salmon etal. 2010 (diversité, peuplement, endémisme).
Ordre SYMPHYPLEONA Börner, 1901 (Fig. 1 G-H) Famille ARRHOPALITIDAE Stach, 1956 Genre Arrhopalites Börner, 1906
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on pages 395-396, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
The baryonic Y-shape confining potential energy and its approximants
Creators: name: Silvestre-Brac, Bernard
name: Semay, Claude
name: Narodetskii, Ilya M.
name: Veselov, A. I.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the validity of replacing the complicated three-body confinement operator of the Y string junction type by three kinds of approximation which are numerically much simpler to handle: a one-body operator with the junction point at the centre of mass, a two-body operator corresponding to half the perimeter of the triangle formed by the three particles, and the average of both. Two different approaches for testing the quality of the approximations are proposed: a geometrical treatment based on the comparison of the potential energy strengths for the various inter quark distances, and a dynamical treatment based on the comparison of the corresponding effective string tensions using a hyperspherical approach. Both procedures give very similar results. It is shown how to simulate the genuine string junction operator by the approximations proposed above. Exact three-body calculations are presented in order to compare quantitatively the various approximations and to confirm our analysis.
description: 28 pages, 5 figures, submitted to EPJ C
Supplementary information from Cell death and survival due to cytotoxic exposure modelled as a two-state Ising system
Creators: name: S. Arbabi Moghadam
name: V. Rezania
name: J. A. Tuszynski
Publisher: name: The Royal Society
Year: 2020
Subjects: Biophysics
Cell Biology
Computational Biology

description: An Overview of the Ising and Landau Models, Data on Cells and Chemotherapy Agents Studied
Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals
Creators: name: Schröder, Christin
name: Peña Diaz, Luis Alberto
name: Rohde, Anna Maria
name: Piening, Brar
name: Aghdassi, Seven Johannes Sam
name: Pilarski, Georg
name: Thoma, Norbert
name: Gastmeier, Petra
name: Leistner, Rasmus
name: Behnke, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: infection control
subject: alarm system
subject: nosocomial
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: INTRODUCTION: Outbreaks of communicable diseases in hospitals need to be quickly detected in order to enable immediate control. The increasing digitalization of hospital data processing offers potential solutions for automated outbreak detection systems (AODS). Our goal was to assess a newly developed AODS. METHODS: Our AODS was based on the diagnostic results of routine clinical microbiological examinations. The system prospectively counted detections per bacterial pathogen over time for the years 2016 and 2017. The baseline data covers data from 2013-2015. The comparative analysis was based on six different mathematical algorithms (normal/Poisson and score prediction intervals, the early aberration reporting system, negative binomial CUSUMs, and the Farrington algorithm). The clusters automatically detected were then compared with the results of our manual outbreak detection system. RESULTS: During the analysis period, 14 different hospital outbreaks were detected as a result of conventional manual outbreak detection. Based on the pathogens' overall incidence, outbreaks were divided into two categories: outbreaks with rarely detected pathogens (sporadic) and outbreaks with often detected pathogens (endemic). For outbreaks with sporadic pathogens, the detection rate of our AODS ranged from 83% to 100%. Every algorithm detected 6 of 7 outbreaks with a sporadic pathogen. The AODS identified outbreaks with an endemic pathogen were at a detection rate of 33% to 100%. For endemic pathogens, the results varied based on the epidemiological characteristics of each outbreak and pathogen. CONCLUSION: AODS for hospitals based on routine microbiological data is feasible and can provide relevant benefits for infection control teams. It offers in-time automated notification of suspected pathogen clusters especially for sporadically occurring pathogens. However, outbreaks of endemically detected pathogens need further individual pathogen-specific and setting-specific adjustments.
Arrhopalites acanthophthalmus Gisin 1958
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Arrhopalitidae
Arrhopalites
Arrhopalites acanthophthalmus

description: Arrhopalites acanthophthalmus Gisin, 1958
Arrhopalites acanthophthalmus Gisin, 1958: 773.
DISTRIBUTION. — Ardèche. Grottede Gaudeprèsde Saint-Étiennede-Fontbellon et aven de Beaume-Cartière près d’Orgnac (Stomp etal. 1982).
Bouches-du-Rhône. Provenceet Camargue (Poinsot 1973, 1974b).
Pyrénées-Orientales. Forêt de hêtres dela Massane, 630 m, près de Banyuls-sur-Mer (Izarra 1980).
ÉCOLOGIE. — Poinsot 1973.
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 396, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Additional file 3 of Systematical identifications of prognostic meaningful lung adenocarcinoma subtypes and the underlying mutational and expressional characters
Creators: name: Zhenyang Lv
name: Lei, Ting
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3: The leave-one-out validation accuracy of the top-10 important genes for predicting the identified LUAD subtypes based on the glmnet algorithm. The best performance was achieved when lambda was set at 0. 0.007137788 and alpha was 1.00.
The Spectrum of Integrated Millimeter Flux of the Magellanic Clouds and 30-Doradus from TopHat and DIRBE Data
Creators: name: Aguirre, J. E.
name: Bezaire, J. J.
name: Cheng, E. S.
name: Cottingham, D. A.
name: Cordone, S. S.
name: Crawford, T. M.
name: Fixsen, D. J.
name: Knox, L.
name: Meyer, S. S.
name: Norgaard-Nielsen, H. U.
name: Silverberg, R. F.
name: Timbie, P.
name: Wilson, G. W.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present measurements of the integrated flux relative to the local background of the Large and Small Magellanic Clouds and the region 30-Doradus (the Tarantula Nebula) in the LMC in four frequency bands centered at 245, 400, 460, and 630 GHz, based on observations made with the TopHat telescope. We combine these observations with the corresponding measurements for the DIRBE bands 8, 9, and 10 to cover the frequency range 245 - 3000 GHz (100 - 1220 micrometers) for these objects. We present spectra for all three objects and fit these spectra to a single-component greybody emission model and report best-fit dust temperatures, optical depths, and emissivity power-law indices, and we compare these results with other measurements in these regions and elsewhere. Using published dust grain opacities, we estimate the mass of the measured dust component in the three regions.
description: 41 pages, 4 figures. Accepted for publication in Astrophysical Journal
Cheumatopsyche thaba Mosely 1948
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche thaba

description: Cheumatopsyche thaba Mosely, 1948
 Cheumatopsyche thaba Mosely, 1948: 70.
 Type locality: Yemen.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on pages 156-157
Non-anticommutative chiral singlet deformation of N=(1,1) gauge theory
Creators: name: Ferrara, S.
name: Ivanov, E.
name: Lechtenfeld, O.
name: Sokatchev, E.
name: Zupnik, B.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the SO(4)x SU(2) invariant Q-deformation of Euclidean N=(1,1) gauge theories in the harmonic superspace formulation. This deformation preserves chirality and Grassmann harmonic analyticity but breaks N=(1,1) to N=(1,0) supersymmetry. The action of the deformed gauge theory is an integral over the chiral superspace, and only the purely chiral part of the covariant superfield strength contributes to it. We give the component form of the N=(1,0) supersymmetric action for the gauge groups U(1) and U(n>1). In the U(1) and U(2) cases, we find the explicit nonlinear field redefinition (Seiberg-Witten map) relating the deformed N=(1,1) gauge multiplet to the undeformed one. This map exists in the general U(n) case as well, and we use this fact to argue that the deformed U(n) gauge theory can be nonlinearly reduced to a theory with the gauge group SU(n).
description: 1+25 pages; v2: corrected eqs.(2.7),(3.12),(4.31-33) and typos; v3: corrected eqs.(3.29),(4.7),(A.5),(A.21), ref. added, published version
From scalar to polar active matter: Connecting simulations with mean-field theory
Creators: name: Jayaram, Ashreya
name: Fischer, Andreas
name: Speck, Thomas
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study numerically the phase behavior of self-propelled elliptical particles interacting through the "hard" repulsive Gay-Berne potential at infinite Péclet number. Changing a single parameter, the aspect ratio, allows to continuously go from discoid active Brownian particles to elongated polar rods. Discoids show phase separation, which changes to a cluster state of polar domains, which then form polar bands as the aspect ratio is increased. From the simulations, we identify and extract the two effective parameters entering the mean-field description: the force imbalance coefficient and the effective coupling to the local polarization. These two coefficients are sufficient to obtain a complete and consistent picture, unifying the paradigms of scalar and polar active matter.
Additional file 2 of Systematical identifications of prognostic meaningful lung adenocarcinoma subtypes and the underlying mutational and expressional characters
Creators: name: Zhenyang Lv
name: Lei, Ting
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 2: Top-ranked differentially expressed genes between samples with and without certain mutations. For each SMG, we separated the samples into mutated and wild type sets, and examined which genes showed significant differential expressions in mRNA level between the mutated and wild type samples. SMGs (yellow nodes) and their relevant differentially expressed genes (blue nodes) are linked by edges. Red and green edge colors respectively represent positive and negative correlations, and the edge width is proportional to the absolute value of log2(Fold Change).
Cheumatopsyche ernstheissi Malicky 1997
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche ernstheissi

description: Cheumatopsyche ernstheissi Malicky, 1997
Fig. 211
 Cheumatopsyche ernstheissi Malicky, 1997: 1034.
 Type locality: Brunei.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 156
X-ray emission from a metal depleted accretion shock onto the classical T Tauri star TW Hya
Creators: name: Stelzer, B.
name: Schmitt, J. H. M. M.
name: ;
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the X-ray spectrum of TW Hya observed at high and intermediate spectral resolution with the Reflection Grating Spectrometer (RGS) and the European Photon Imaging Camera (EPIC) onboard the XMM-Newton satellite. TW Hya is the first classical T Tauri star for which simultaneous X-ray data with both high spectral resolution and high sensitivity were obtained, thus allowing to probe the X-ray emission properties of stars in the early pre-main sequence phase. The high plasma density, the (comparatively) low temperature, and peculiar chemical abundances in the X-ray emitting region on TW Hya are untypical for stellar coronae. An alternative X-ray production mechanism is therefore called for and a natural explanation is an accretion column depleted of grain forming elements. The metal depletion could be either due to the original molecular cloud that formed TW Hya or due to a settling of dust in the circumstellar disk of TW Hya.
description: 11 pages, accepted for publication in A&A
Red variables in the OGLE-II database. I. Pulsations and period-luminosity relations below the tip of the Red Giant Branch of the LMC
Creators: name: Kiss, L. L.
name: Bedding, T.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present period-luminosity relations for more than 23,000 red giants in the Large Magellanic Cloud observed by the OGLE-II microlensing project. The OGLE period values were combined with the 2MASS single-epoch JHK photometric data. For the brighter stars we find agreement with previous results (four different sequences corresponding to different modes of pulsation in AGB stars). We also discovered two distinct and well-separated sequences below the tip of the Red Giant Branch. They consist of almost 10,000 short-period (15 d
description: 5 pages, 4 figures; accepted for publication in MNRAS (Pink Pages); proof corrections added
Arrhopalites bifidus Stach 1956
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Arrhopalitidae
Arrhopalites
Arrhopalites bifidus

description: Arrhopalites bifidus Stach, 1945 sensu Stach 1956
Arrhopalites bifidus Stach, 1945: 34; 1956: 83.
DISTRIBUTION. — Nièvre. Parcrégionaldu Morvan (Ponge etal. 2003).
Nord. Bois des Asturies près d’Auby (Gillet & Ponge 2003).
ÉCOLOGIE. — Gillet & Ponge 2003 (pollution, métaux); Ponge etal. 2003 (bioindicateur).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 396, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272