cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of p53 by Mdm2 E3 Ligase Function Is Dispensable in Embryogenesis and Development, but Essential in Response to DNA Damage
Creators: name: Park, Jikyoung
name: Jin, Aiwen
name: Tollini, Laura A.
name: Zhang, Yanping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Mdm2 E3 ubiquitin ligase-mediated p53 degradation is generally accepted as the major mechanism for p53 regulation; nevertheless, the in vivo significance of this function has not been unequivocally established. Here, we have generated an Mdm2Y487A knock-in mouse; Mdm2Y487A mutation inactivates Mdm2 E3 ligase function without affecting its ability to bind its homologue MdmX. Unexpectedly, Mdm2Y487A/Y487A mice were viable and developed normally into adulthood. While disruption of Mdm2 E3 ligase function resulted in p53 accumulation, p53 transcriptional activity remained low; however, exposure to sub-lethal stress resulted in hyperactive p53 and p53-dependent mortality in Mdm2Y487A/Y487A mice. These findings reveal a potentially dispensable nature for Mdm2 E3 ligase function in p53 regulation, providing insight that may affect how this pathway is targeted therapeutically.
KRIMINALISTIKADA RAQAMLI TEXNOLOGIYALAR
Creators: name: Mansurov, Oybek
Publisher: name: Zenodo
Year: 2023

description: Sud ekspertiza faoliyatini raqamlashtirish bir necha jihatlarda ko'rib chiqiladi: tergovchining qidiruv va kognitiv faoliyati samaradorligini oshirish uchun raqamli texnologiyalardan foydalanish, ushbu faoliyatni samarali tashkil etish, shuningdek, kompyuter texnikasi, dasturiy ta'minot va jinoyatlarni tergov qilish texnologiyalari. "Virtual izlar" haqidagi munozara misoli bu masalaning murakkabligini ko'rsatadi. Bunga munosabat bildiriladi.
title: Imaging of chest wall abnormalities: The shapeless cage!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Bones
subject: Mediastinum
subject: CT
subject: Plain radiographic studies
subject: Computer Applications-Detection, diagnosis
subject: Normal variants
subject: Congenital
subject: Developmental disease
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Chest wall abnormalities usually include congenital ,inflammatory ,infectious ,soft tissue and bone tumors. CT and MRI plays a key role in identification of abnormality and giving optimal...
title: Imaging of Traumatic ossicular dislocation: The 3 Musketeers!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Ear / Nose / Throat
subject: Trauma
subject: CT
subject: CT-High Resolution
subject: Computer Applications-3D
subject: Surgery
subject: Outcomes
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Traumatic ossicular dislocation is a frequent complication of temporal bone injury. The most common cause of ossicular injury is blow trauma to the temporal ,parietal and occipital region. CT is the method of choice for evaluation of ossicular...
(401883) Finlay Finlayson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Reflections on the Culture of the New and the Second Hand in Italy
Creators: name: Setiffi, Francesca
Publisher: name: QuiEdit
Year: 2015
Subjects: material culture; consumption; second-hand culture

description: The purpose of this essay is to interpret changes in consumer society through the socio-anthropological concept of material culture. Consumption, which is an act of social communication, is expressed through the acquisition and circulation of goods. To consider material culture as an area of symbolic mediation means assuming that it is a means of interpreting social reality, where the notion of what we consider as ‘new’ or ‘used’ acquires a value transcending the substance of the goods, emphasizing, on the contrary, their symbolic meaning.
description: Italian Sociological Review, Vol 1, No 3 (2011)
Supplementary material from “Optically-ambidextrous circularly-polarised reflection from the chiral cuticle of the scarab beetle Chrysina resplendens”
Creators: name: Finlayson, Ewan D.
name: McDonald, Luke T.
name: Vukusic, Pete
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Figure S1 shows experimental measurements of circular polarisation reflectance for a sample of eighty positions on the dorsal surface of the elytron. The results indicate that the main features of the CP spectra are consistently present across the sample of locations, and that some variation in the relative intensities and spectral positions of the features is observed. Figure S2 shows experimental measurements of circular polarisation reflectance, performed on a prepared piece of elytron following removal of the endocuticle. Seven sets of measurements were made for incidence upon the dorsal surface and for incidence upon the exposed surface of the underside of the exocuticle. The results support the view that the spectra shown in figure 3b are typical of the exocuticle for incidence upon its exposed underside surface. The results also show that for incidence upon the dorsal surface the main spectral features seen in figure S1 were still observed following endocuticle removal. Figure S3 shows examples of SEM images of fractured sections of the exocuticle of the elytron. Figure S4 shows a schematic of the circular-polarisation reflectance measurement setup.
title: Imaging of Persistent Hyperplastic Primary Vitreous-Don’t hold it for too long!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Eyes
subject: CT
subject: MR
subject: Ultrasound
subject: Computer Applications-Detection, diagnosis
subject: Imaging sequences
subject: Congenital
subject: Developmental disease

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To use combine approach of the imaging modalities to identify and evaluate the persistent hyperplastic primary...
The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression
Creators: name: Dominguez, Daniel
name: Chen, Dan
name: Qian, Haili
name: Wang, Zefeng
name: Shao, Shujuan
name: Tsai, Yihsuan S.
name: Liu, Quentin
name: Wang, Yang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Splicing dysregulation is one of the molecular hallmarks of cancer. However, the underlying molecular mechanisms remain poorly defined. Here we report the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing. Particularly, RBM4 regulates Bcl-x splicing to induce apoptosis, and co-expression of Bcl-xL partially reverses the RBM4-mediated tumor suppression. Moreover, RBM4 antagonizes an oncogenic splicing factor, SRSF1, to inhibit mTOR activation. Strikingly, RBM4 expression is dramatically decreased in cancer patients, and RBM4 level is positively correlated with improved survival. In addition to providing mechanistic insights of cancer-related splicing dysregulation, this study establishes RBM4 as a tumor suppressor with therapeutic potentials and clinical values as a prognostic factor.
(401879) Caroline Esther Russell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Re-entrant percolation in active Brownian hard disks
Creators: name: Evans, David
name: Martín-Roca, José
name: Harmer, Nathan J.
name: Valeriani, Chantal
name: Miller, Mark A.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Non-equilibrium clustering and percolation are investigated in an archetypal model of two-dimensional active matter using dynamic simulations of self-propelled Brownian repulsive particles. We concentrate on the single-phase region up to moderate levels of activity, before motility-induced phase separation (MIPS) sets in. Weak activity promotes cluster formation and lowers the percolation threshold. However, driving the system further out of equilibrium partly reverses this effect, resulting in a minimum in the critical density for the formation of system-spanning clusters and introducing re-entrant percolation as a function of activity in the pre-MIPS regime. This non-monotonic behaviour arises from competition between activity-induced effective attraction (which eventually leads to MIPS) and activity-driven cluster breakup. Using an adapted iterative Boltzmann inversion method, we derive effective potentials to map weakly active cases onto a passive (equilibrium) model with conservative attraction, which can be characterised by Monte Carlo simulations. While the active and passive systems have practically identical radial distribution functions, we find decisive differences in higher-order structural correlations, to which the percolation threshold is highly sensitive. For sufficiently strong activity, no passive pairwise potential can reproduce the radial distribution function of the active system.
title: T2 hyperintense spinal cord lesions: Shining stars of the cord!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology spine
subject: MR
subject: MR-Spectroscopy
subject: Complications
subject: Imaging sequences
subject: Cancer
subject: Inflammation
subject: Oedema

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To have a clear cut idea of normal spinal cord anatomy and assessment of the lesions of the cord using magnetic resonance imaging .Intramedullary cord hyperintensity at T2-weighted MRI is a common imaging feature of disease in the spinal cord, but...
Further results and discussion from Robust estimation of risks from small samples.
Creators: name: Tindemans, Simon H.
name: Strbac, Goran
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: 10299 Applied Mathematics not elsewhere classified

description: Data-driven risk analysis involves the inference of probability distributions from measured or simulated data. In the case of a highly reliable system, such as the electricity grid, the amount of relevant data is often exceedingly limited, but the impact of estimation errors may be very large. This paper presents a robust non-parametric Bayesian method to infer possible underlying distributions. The method obtains rigorous error bounds even for small samples taken from ill-behaved distributions. The approach taken has a natural interpretation in terms of the intervals between ordered observations, where allocation of probability mass across intervals is well specified, but the location of that mass within each interval is unconstrained. This formulation gives rise to a straightforward computational resampling method: Bayesian interval sampling. In a comparison with common alternative approaches, it is shown to satisfy strict error bounds even for ill-behaved distributions.
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
Creators: name: Flaveny, Colin A.
name: Walker, John
name: Chatterjee, Arindam
name: Griffett, Kristine
name: El-Gendy, Bahaa El Dien M.
name: Kazantzis, Melissa
name: Kamenecka, Theodore M.
name: Burris, Thomas P.
name: Solt, Laura A.
name: Amelio, Antonio L.
name: Sengupta, Monideepa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The nuclear receptor liver-X-receptor (LXR) directly regulates expression of key glycolytic and lipogenic genes. To disrupt these oncogenic metabolism pathways, we designed an LXR inverse agonist SR9243 that induces LXR-corepressor interaction. In cancer cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression. SR9243 induced apoptosis in tumors without inducing weight loss, hepatotoxicity, or inflammation. Our results suggest that LXR inverse agonists may be an effective cancer treatment approach.
title: Tropical eosinophilia: Fleeting and Flaring of the tropics.
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Haematologic
subject: Lung
subject: Respiratory system
subject: CT
subject: Plain radiographic studies
subject: Imaging sequences
subject: Laboratory tests
subject: Infection
subject: Parasites
subject: Tropical diseases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To use the aid of high resonance computed tomography to detect the lung patterns and types of involvement in case of tropical eosinophilia and helps in arriving the diagnosis . Tropical eosinophilia has been a widespread disease in the tropics...
(401880) Martin Edmunds
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Optimum Bleaching Efficiency of Activated Ntezi Bentonite using Response Surface Methodology
Creators: name: Ajemba, Regina
name: Nweke, Chinenyenwa
name: John, Sunday
name: Ejiofor, Calista
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 400408
subject: Reaction engineering (excl. nuclear reactions)
classificationCode: 400499
subject: Chemical engineering not elsewhere classified

description: The optimization of the bleaching efficiency of acid-activated Ntezi bentonite was studied by reacting raw bentonite with different concentrations of hydrochloric acid solution for varying periods to activate it. The raw and activated samples were characterized using X-ray fl uorescence. The activated samples were used to bleach palm oil and the effects of bleaching process variables were investigated using the Response Surface Methodology (RSM). Results of the analysis showed that the structure of the bentonite was altered by the acid activation and this increased the adsorptive capacity of the activated samples. The statistical analysis indicated that the main and quadratic effects of the bleaching process parameters were signifi cant at the 95% confi dence level. The optimum conditions were determined to be: reaction temperature 156.66°C; reaction time, 2.74 hours; adsorbent dosage, 5.93 g; adsorbent/oil ratio, 0.04 g/ml; and stirring speed, 411.62 rpm. Under these conditions, the optimum bleaching effi ciency was determined to be 85.48%, which agreed with the experimental value of 86.07%. This study showed that Ntezi bentonite can be used as an effective adsorbent under optimized process conditions.
Deflationary measures and the reduction of individual costs in family crises
Creators: name: Cordiano, Alessandra
Publisher: name: QuiEdit
Year: 2015
Subjects: family; regulations; process

description: This paper provides an overview of the legal situation with regard to new family types that differ from legitimate and natural families (such as homosexual, foreign and reconstituted families). A highly complex picture emerges featuring a “new measure of protection”, which essentially takes shape in the means and
compositional strategies of the conflict. On one hand it defines the need for the relevant legal professionals to be able to act using deflationary and conciliatory methods in cases and family crises. On the other hand, however, it prompts a rethinking of existing practices and measures in force in the light of a different culture of settling family litigation, leading to genuinely endorsed choices and effective reduction of the emotional and individual costs borne by the subjects involved.
description: Italian Sociological Review, Vol 1, No 3 (2011)
Women and Work in Italy: the Risk of Discouragement. With a Southern Italian Case Study.
Creators: name: Carrera, Letizia
Publisher: name: QuiEdit
Year: 2015
Subjects: women; job; discouragement

description: The difficult relationship between women and work in Italy appears disconcerting at national level and becomes really alarming at Southern Italy ones. We have chosen here to consider a particular phenomenon which, in Italy, is especially referred to women: «discouragement». This is the condition of some women who, after having looked for a job for long time and uselessly, at the end, decide to give up looking for it. Going beyond quantitative data, we have made also a empiric survey on one hundred of unemployed women to investigate discouragement process in a Southern Italy region.
description: Italian Sociological Review, Vol 1, No 3 (2011)
Profitability of simple technical trading rules of Chinese stock exchange indexes
Creators: name: Zhu, Hong
name: Jiang, Zhi-Qiang
name: Li, Sai-Ping
name: Zhou, Wei-Xing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Trading and Market Microstructure (q-fin.TR)
subject: Statistical Finance (q-fin.ST)
subject: FOS: Economics and business

description: Although technical trading rules have been widely used by practitioners in financial markets, their profitability still remains controversial. We here investigate the profitability of moving average (MA) and trading range break (TRB) rules by using the Shanghai Stock Exchange Composite Index (SHCI) from May 21, 1992 through December 31, 2013 and Shenzhen Stock Exchange Composite Index (SZCI) from April 3, 1991 through December 31, 2013. The $t$-test is adopted to check whether the mean returns which are conditioned on the trading signals are significantly different from unconditioned returns and whether the mean returns conditioned on the buy signals are significantly different from the mean returns conditioned on the sell signals. We find that TRB rules outperform MA rules and short-term variable moving average (VMA) rules outperform long-term VMA rules. By applying White's Reality Check test and accounting for the data snooping effects, we find that the best trading rule outperforms the buy-and-hold strategy when transaction costs are not taken into consideration. Once transaction costs are included, trading profits will be eliminated completely. Our analysis suggests that simple trading rules like MA and TRB cannot beat the standard buy-and-hold strategy for the Chinese stock exchange indexes.
description: 12 pages including 1 figure and 4 tables
Further results and discussion from Robust estimation of risks from small samples
Creators: name: Tindemans, Simon H.
name: Strbac, Goran
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: 10299 Applied Mathematics not elsewhere classified

description: Data-driven risk analysis involves the inference of probability distributions from measured or simulated data. In the case of a highly reliable system, such as the electricity grid, the amount of relevant data is often exceedingly limited, but the impact of estimation errors may be very large. This paper presents a robust non-parametric Bayesian method to infer possible underlying distributions. The method obtains rigorous error bounds even for small samples taken from ill-behaved distributions. The approach taken has a natural interpretation in terms of the intervals between ordered observations, where allocation of probability mass across intervals is well specified, but the location of that mass within each interval is unconstrained. This formulation gives rise to a straightforward computational resampling method: Bayesian Interval Sampling. In a comparison with common alternative approaches, it is shown to satisfy strict error bounds even for ill-behaved distributions.
Augmenting the diboson excess for Run 2
Creators: name: Goncalves, Dorival
name: Krauss, Frank
name: Spannowsky, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The ATLAS collaboration recently reported an excess of events in the high invariant mass tail of reconstructed di-boson events. We investigate their analysis and point to possible subtleties and improvements in the jet substructure implementation and data-driven background estimates.
description: 10 pages, 5 figures and 1 table; v2: references added
title: Space occupying lesions of cerebello-pontine angle: The inner trouble!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Oncology
subject: CT
subject: MR
subject: MR-Diffusion/Perfusion
subject: Imaging sequences
subject: Localisation
subject: Staging
subject: Cancer
subject: Cysts
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To effectively know the anatomy of cerebello pontine angle and detecting the space occupying lesions of the CP angle using diagnostic imaging (CT AND MRI) and presenting in a comprehensive way...
Supplementary methods and figures from Testing the molecular clock using mechanistic models of fossil preservation and molecular evolution.
Creators: name: Warnock, Rachel C. M.
name: Ziheng Yang
name: Donoghue, Philip C. J.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: Computational Biology

description: Molecular sequence data provide information about relative times only, and fossil-based age constraints are the ultimate source of information about absolute times in molecular clock dating analyses. Thus, fossil calibrations are critical to molecular clock dating, but competing methods are difficult to evaluate empirically because the true evolutionary time scale is never known. Here, we combine mechanistic models of fossil preservation and sequence evolution in simulations to evaluate different approaches to constructing fossil calibrations and their impact on Bayesian molecular clock dating, and the relative impact of fossil versus molecular sampling. We show that divergence time estimation is impacted by the model of fossil preservation, sampling intensity and tree shape. The addition of sequence data may improve molecular clock estimates, but accuracy and precision is dominated by the quality of the fossil calibrations. Posterior means and medians are poor representatives of true divergence times; posterior intervals provide a much more accurate estimate of divergence times, though they may be wide and often do not have high coverage probability. Our results highlight the importance of increased fossil sampling and improved statistical approaches to generating calibrations, which should incorporate the non-uniform nature of ecological and temporal fossil species distributions.
(401881) James Edmunds
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Erythropoietin Stimulates Tumor Growth via EphB4
Creators: name: Brock, Stephan
name: Noh, Kyunghee
name: Dalton, Heather J.
name: Han, Hee Dong
name: Li, Chun
name: Stone, Rebecca L.
name: Wu, Sherry Y.
name: Nick, Alpa M.
name: Mora, Edna M.
name: Pecot, Chad V.
name: Alpay, S. Neslihan
name: Rodriguez-Aguayo, Cristian
name: Xiong, Chiyi
name: Armaiz-Peña, Guillermo N.
name: Kruger, Carola
name: Haghpeykar, Shyon
name: Coleman, Robert L.
name: Jaladurgam, Padmavathi
name: Urbauer, Diana
name: Jackson, David B.
name: Matsuo, Koji
name: Mangala, Lingegowda S.
name: Wen, Yunfei
name: Huang, Jie
name: Gharpure, Kshipra
name: Sood, Anil K.
name: Danes, Christopher
name: Hung, Mien Chie
name: Cho, Min Soon
name: Pradeep, Sunila
name: Schneider, Armin
name: Nagaraja, Archana S.
name: Zand, Behrouz
name: Stein, Martin A.
name: Nishimura, Masato
name: Ladbury, John E.
name: Liu, Jinsong
name: Vivas-Mejia, Pablo
name: Goodman, Blake
name: Stagg, Loren J.
name: Hansen, Jean M.
name: Rupaimoole, Rajesha
name: Hu, Wei
name: Previs, Rebecca A.
name: Ozpolat, Bulent
name: Lopez-Berestein, Gabriel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo’s effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin.
On The $j$-Invariants of CM-Elliptic Curves Defined Over $\mathbb{Z}_p$
Creators: name: Fiori, Andrew
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We characterize the possible reductions of $j$-invariants of elliptic curves which admit complex multiplication by an order $\mathcal{O}$ where the curve itself is defined over $\mathbb{Z}_p$. In particular, we show that the distribution of these $j$-invariants depends on which primes divide the discriminant and conductor of the order.
description: 14 pages
title: Combined diagnostic accuracy of Diffusion and Perfusion MR Imaging to differentiate radiation induced necrosis from recurrence in Glioblastoma
Creators: name: Khoda, Jeevitesh
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: Oncology
subject: MR
subject: MR-Diffusion/Perfusion
subject: Contrast agent-intravenous
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: We aimed to use quantitative values derived from perfusion and diffusion weighted MR imaging (PWI & DWI) to differentiate radiation induced necrosis (RIN) from tumor recurrence in Glioblastoma (GBM) and investigate the best parameters for improved...
Firewood ABM ODD from The impacts of climate change, energy policy and traditional ecological practices on future firewood availability for Diné (Navajo) People
Creators: name: Magargal, Kate
name: Wilson, Kurt
name: Chee, Shaniah
name: Campbell, Michael J.
name: Bailey, Vanessa
name: Dennison, Philip E.
name: Anderegg, William R. L.
name: Cachelin, Adrienne
name: Brewer, Simon
name: Codding, Brian Frank
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: Animal Behaviour

description: A document detailing the process followed by the ABM. This is in the standardized ABM ODD format.
Design de interface educativa a partir da avaliação do impacto na aprendizagem por Scaffolding
Creators: name: Queiroz, Ana Emilia
name: Gomes, Alex Sandro
Publisher: name: Zenodo
Year: 2023

description: This paper reports the design of Scaffolds aids in an
educational interface. We used a constructivist framework
to make possible to investigate the meanings that emerge
during the actions using an educational software. To carry
out this investigation, a prototype was designed and tested
with elementary school teachers. The results made it
possible to design scaffolding strategies that improves the
sense making of concepts that emerges during the software
usage.
(401878) William Dixon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Imaging of Bronchial lesions – Broadway to the bronchi!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Lung
subject: Mediastinum
subject: CT
subject: Plain radiographic studies
subject: Computer Applications-Detection, diagnosis
subject: Normal variants
subject: Cancer
subject: Metastases
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To discuss the normal anatomical features of bronchus and its clinical relevance , recognize the features of various bronchial lesion which appears in the form of either bronchial wall thickening or causing stenosis of the airway and differentiate...
Phase I and pharmacokinetic trial of carboplatin and albumin-bound paclitaxel, ABI-007 (Abraxane®) on three treatment schedules in patients with solid tumors
Creators: name: Mu, Hua
name: O'Neil, Bert H.
name: Lindley, Celeste
name: Walko, Christine M.
name: Hawkins, Michael J.
name: Claire Dees, E.
name: Ivanova, Anastasia
name: Goldberg, Richard M.
name: Socinski, Mark A.
name: Stinchcombe, Thomas E.
name: Collichio, Frances A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Albumin-bound paclitaxel, ABI-007 (Abraxane ®), has a different toxicity profile than solvent-based paclitaxel, including a lower rate of severe neutropenia. The combination of ABI-007 and carboplatin may have significant activity in a variety of tumor types including non-small and small cell lung cancer, ovarian cancer, and breast cancer. The purpose of this study was to determine the maximum tolerated dose (MTD) of ABI-007, on three different schedules in combination with carboplatin.
title: Imaging of diseases of the clavicle – White collar Radiologists.
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Musculoskeletal bone
subject: Trauma
subject: CT
subject: Plain radiographic studies
subject: Computer Applications-3D
subject: Sclerosis
subject: Athletic injuries
subject: Cancer
subject: Metastases

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The clavicle is a superficial S-shaped long bone that is also known as the collar bone .Diseases of the clavicle are usually easily picked up, because of its superficial location, however, they are difficult to diagnose correctly in many instances...
A phase I and pharmacologic study of the combination of bortezomib and pegylated liposomal doxorubicin in patients with refractory solid tumors
Creators: name: Esseltine, Dixie
name: Lindley, Celeste M.
name: Collichio, Frances
name: Carey, Lisa A.
name: O'Neil, Bert H.
name: Dees, E. Claire
name: Riordan, William J.
name: Ivanova, Anastasia
name: Orlowski, Robert Z.
name: Collins, Jason
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Pre-clinical studies combining the proteasome inhibitor bortezomib with anthracyclines have shown enhanced anti-tumor activity. We therefore conducted a phase I trial of bortezomib and pegylated liposomal doxorubicin (PLD) in patients with refractory solid tumors.
Second-order Barker-Henderson perturbation theory for the phase behavior of polydisperse Morse hard-sphere mixture
Creators: name: Hvozd, T. V.
name: Kalyuzhnyi, Yu. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We propose an extension of the second-order Barker-Henderson perturbation theory for polydisperse hard-sphere multi-Morse mixture. To verify the accuracy of the theory, we compare its predictions for the limiting case of monodisperse system, with predictions of the very accurate reference hypernetted chain approximation. The theory is used to describe the liquid-gas phase behavior of the mixture with different type and different degree of polydispersity. In addition to the regular liquid-gas critical point, we observe the appearance of the second critical point induced by polydispersity. With polydispersity increase, the two critical points merge and finally disappear. The corresponding cloud and shadow curves are represented by the closed curves with 'liquid' and 'gas' branches of the cloud curve almost coinciding for higher values of polydispersity. With a further increase of polydispersity, the cloud and shadow curves shrink and finally disappear. Our results are in agreement with the results of the previous studies carried out on the qualitative van der Waals level of description.
description: 13 pages, 4 figures
Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors
Creators: name: Hardee, Matthew E.
name: Dewhirst, Mark W.
name: Dreher, Matthew R.
name: Eapen, Rose J.
name: Marks, Jeffrey
name: Blackwell, Kimberly L.
name: Rabbani, Zahid N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Tumor hypoxia reduces the efficacy of radiation and chemotherapy as well as altering gene expression that promotes cell survival and metastasis. The growth factor receptor, Her2/neu, is overexpressed in 25–30% of breast tumors. Tumors that are Her2+ may have an altered state of oxygenation, relative to Her2−tumors, due to differences in tumor growth rate and angiogenesis.
Diffused religion and civil society in Italy
Creators: name: Cipriani, Roberto
Publisher: name: QuiEdit
Year: 2015
Subjects: religion; civil society

description: “Diffused religion” is to be understood in at least a double sense. First of all, it is diffused in that it comprises vast sections of the population and goes beyond the simple limits of church religion. Besides, it has become widespread, since it has been shown to be a historical and cultural result of the almost bi-millennial presence of the Catholic institution in Italy and of its socializing and legitimizing action. However values diffused in the Italian civil society can be considered as a form of conflict with the established institution of Catholic Church. Civil society shows a peculiar trend towards civic freedoms and ethical pluralism. Although the Catholic perspective is dominant, the civil society prefers a different system of values, even though not so much different from ecclesiastical social doctrine. This way there is a public space where religion is not the reference point and other perspectives take place.
description: Italian Sociological Review, Vol 1, No 2 (2011)
Family, Personal Networks and Social Capital
Creators: name: Di Nicola, Paola
Publisher: name: QuiEdit
Year: 2015
Subjects: family; social capital; personal networks

description: The aim of this article is, using a survey taken on a representative sample of the Italian population as our starting point, to verify whether support networks can still be considered a resource for Italians (and if so how far these networks reach and how intense the flows of help individuals can draw on in their primary networks are) and to investigate more closely to what extent the existence of such a network affects the degree of satisfaction the average Italian expresses regarding certain fundamental aspects of daily life: economic resources, family, friends, work, free time and health. The results of the study demonstrate that the primary social capital available to Italians has been seriously eroded in recent years and that satisfaction levels are linked much more closely to the stage an individual has reached in their life cycle than to the amount of social capital available to them.
description: Italian Sociological Review, Vol 1, No 2 (2011)
title: Imaging of the pelvic floor – Basics of the base
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Genital / Reproductive system male
subject: Pelvis
subject: MR
subject: MR-Functional imaging
subject: Ultrasound
subject: Abscess delineation
subject: Defecography
subject: Abscess
subject: Fistula
subject: Pelvic floor dysfunction

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the relevant anatomy and sonographic, fluoroscopic, and MRI options for evaluating patients with pelvic floor...
(401875) William Frederick Henderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary methods and figures from Testing the molecular clock using mechanistic models of both fossil preservation and molecular evolution
Creators: name: Warnock, Rachel C. M.
name: Ziheng Yang
name: Donoghue, Philip C. J.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: Computational Biology

description: Molecular sequence data provide information about relative times only, and fossil-based age constraints are the ultimate source of information about absolute times in molecular clock dating analyses. Thus, fossil calibrations are critical to molecular clock dating, but competing methods are difficult to evaluate empirically because the true evolutionary timescale is never known. Here, we combine mechanistic models of fossil preservation and sequence evolution in simulations to evaluate different approaches to constructing fossil calibrations and their impact on Bayesian molecular clock dating, and the relative impact of fossil versus molecular sampling. We show that divergence time estimation is impacted by the model of fossil preservation, sampling intensity and tree shape. The addition of sequence data may improve molecular clock estimates, but accuracy and precision is dominated by the quality of the fossil calibrations. Posterior means and medians are poor representatives of true divergence times; posterior intervals provide a much more accurate estimate of divergence times, though they may be wide and often do not have high coverage probability. Our results highlight the importance of increased fossil sampling and improved statistical approaches to generating calibrations, which should incorporate the non-uniform nature of ecological and temporal fossil species distributions.
Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors
Creators: name: Cohen, Roger B.
name: Jones, Suzanne
name: Eton, Omar
name: Liu, Hua
name: Danaee, Hadi
name: O'Neil, Bert H.
name: Manfredi, Mark
name: Galvin, Katherine
name: Burris, Howard
name: Ecsedy, Jeffrey
name: Dees, E. Claire
name: Infante, Jeffrey R.
name: Stringer, Bradley
name: Von Mehren, Margaret
name: Fingert, Howard
name: Lee, Yih
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Aurora A kinase is critical in assembly and function of the mitotic spindle. It is overexpressed in various tumor types and implicated in oncogenesis and tumor progression. This trial evaluated the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of MLN8054, a selective small-molecule inhibitor of Aurora A kinase.
title: Imaging of Coccygeal pathologies- Don’t sit and scream!
Creators: name: Ilangovan, Gurubharath
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Oncology
subject: Trauma
subject: CT
subject: MR
subject: Plain radiographic studies
subject: Imaging sequences
subject: Localisation
subject: Cancer
subject: Congenital
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The coccygeal region has complex anatomy, much of which may contribute to or be the cause of coccyx region pain (coccydynia). This anatomy is well depicted at imaging, and management is often dictated by what structures are involved. Coccydynia...
Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells
Creators: name: Barbier, M.
name: DeKrafft, K. E.
name: Collins, L.
name: Cicurel, L.
name: Swenberg, J. A.
name: Chaney, S. G.
name: King, C. L.
name: Lin, W.
name: Ramachandran, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To characterize the cellular action mechanism of Debio 0507, we compared the major DNA adducts formed by Debio 0507- and oxaliplatin-treated HCT116 human colon carcinoma cells by a combination of inductively coupled plasma mass spectrometry (ICP-MS) and ultra-performance liquid chromatography mass spectrometry (UPLC-MS/MS).
ALMA resolves the spiraling accretion flow in the luminous OB cluster forming region G33.92+0.11
Creators: name: Liu, Hauyu Baobab
name: Galván-Madrid, Roberto
name: Jiménez-Serra, Izaskun
name: Román-Zúñiga, Carlos
name: Zhang, Qizhou
name: Li, Zhiyun
name: Chen, Huei-Ru
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: How rapidly collapsing parsec-scale massive molecular clumps feed high-mass stars, and how they fragment to form OB clusters, have been outstanding questions in the field of star-formation. In this work, we report the resolved structures and kinematics of the approximately face-on, rotating massive molecular clump, G33.92+0.11. Our high resolution Atacama Large Millimeter/submillimeter Array (ALMA) images show that the spiral arm-like gas overdensities form in the eccentric gas accretion streams. First, we resolved that the dominant part of the $\sim$0.6 pc scale massive molecular clump (3.0$^{+2.8}_{-1.4}$$\cdot$10$^{3}$ $M_{\odot}$) G33.92+0.11 A is tangled with several 0.5-1 pc size molecular arms spiraling around it, which may be connected further to exterior gas accretion streams. Within G33.92+0.11 A, we resolved the $\sim$0.1 pc width gas mini-arms connecting with the two central massive (100-300 $M_{\odot}$) molecular cores. The kinematics of arms and cores elucidate a coherent accretion flow continuing from large to small scales. We demonstrate that the large molecular arms are indeed the cradles of dense cores, which are likely current or future sites of high-mass star formation. Since these deeply embedded massive molecular clumps preferentially form the highest mass stars in the clusters, we argue that dense cores fed by or formed within molecular arms play a key role in making the upper end of the stellar and core mass functions.
description: 20 pages, formally published by ApJ