cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Enzyme-responsive nanomaterials for controlled drug delivery
Creators: name: Hu, Quanyin
name: Katti, Prateek S.
name: Gu, Zhen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Enzymes underpin physiological function and exhibit dysregulation in many disease-associated microenvironments and aberrant cell processes. Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials for controlled drug release have achieved significant development and been studied as an important class of drug delivery devices in nanomedicine. In this review, we describe enzymes such as proteases, phospholipase and oxidoreductases that serve as delivery triggers. Subsequently, we explore recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. We conclude by discussing future opportunities and challenges in this area.
Il terremoto dell’Aquila e il progetto INCIPICT – Innovating City Planning through Information and Communications Technology: nuovi strumenti per la Public HIstory [poster]
Il terremoto dell’Aquila e il progetto INCIPICT – Innovating City Planning through Information and Communications Technology: nuovi strumenti per la Public HIstory [poster]
Creators: name: Brusaporci, Stefano
name: Mantini, Silvia
name: Tata, Alessandra
name: Boero, Stefano
name: Maiezza, Pamela
name: Graziosi, Fabio
Publisher: name: S. Brusaporci et al., "Il terremoto dell’Aquila e il progetto INCIPICT – Innovating City Planning through Information and Communications Technology: nuovi strumenti per la Public HIstory", in Metti la storia al lavoro! Seconda conferenza italiana di Public History. Pisa, 11-15 giugno 2018
Year: 2025

description: A nove anni dal sisma del 6 aprile 2009 L’Aquila si contraddistingue per la presenza di un cantiere che occupa la quasi totalità del centro storico. Con lo scopo di sostenere la ricerca, il Comitato Interministeriale per la Programmazione Economica (CIPE), ha finanziato il progetto triennale (2015-2018) INCIPICT.
Application of liquid chromatography-mass spectrometry-based metabolic profiling in inflammatory bowel disease
Creators: name: Gallagher, Kate Ellen Iris
Publisher: name: Imperial College London
Year: 2022

description: The inflammatory bowel diseases (IBD), Crohn’s Disease (CD) and Ulcerative colitis (UC), are chronic inflammatory diseases of the gastrointestinal tract, whose aetiology has yet to be determined, but is widely thought to be the result of genetic, immune, microbial, metabolic and environmental influences. IBD has been the subject of microbial and metabolomic research for many years due to associations between UC, CD and alterations in the gut microbiome, as well as measurable changes in systemic metabolism. In this thesis, the breadth of metabolomic research in IBD across multiple human biosamples has been documented in a systematic review. The majority of studies have used untargeted ‘global profiling’ techniques and the review highlights potential advantages that a targeted metabolomic and lipidomic approach to IBD research may bring. The first IBD-specific and targeted liquid-chromatography mass-spectrometry method was developed and validated. The method also employed a novel application of a derivatizing agent to stool samples, as well as previously studied urine and blood components. The application of this method in multiple biosamples showed alterations in concentrations of key microbial and mammalian molecules, comparing IBD patients to healthy controls. The utility of this method when compared to untargeted approaches was also explored, demonstrating the potential advantages of targeted metabolomic methods in IBD research. Results from a lipidomic analysis of IBD stool samples showed significant differences in bioactive lipid species in the stool samples of both UC and CD patients compared to healthy controls. This analysis was integrated with 16S ribosomal RNA (16S rRNA) gene-based sequencing data, identifying correlations between IBD associated bacterial groups and significantly altered stool lipids. This study was also the first to attempt to measure oxylipins in human stool samples. The studies undertaken in this thesis demonstrate the potential of targeted metabolomic analyses in IBD, through novel mass spectrometry approaches.
Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery
Creators: name: Wagner, Kyle T.
name: Lara, Haydee
name: Wang, Andrew Z.
name: Sethi, Manish
name: Zhang, Longzhen
name: Tian, Xi
name: Caster, Joseph M.
name: Hyder, Syed Nabeel
name: Saripalli, Srinivas
name: Foote, Michael
name: Wang, Edina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Radiotherapy is a key component of cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic index of radiotherapy. DNA double-strand repair inhibitors (DSBRIs) are among the most promising agents to improve radiotherapy. However, their clinical translation has been limited by their potential toxicity to normal tissue. Recent advances in nanomedicine offer an opportunity to overcome this limitation. In this study, we aim to demonstrate the proof of principle by developing and evaluating nanoparticle (NP) formulations of KU55933, a DSBRI. We engineered a NP formulation of KU55933 using nanoprecipitation method with different lipid polymer nanoparticle formulation. NP KU55933 using PLGA formulation has the best loading efficacy as well as prolonged drug release profile. We demonstrated that NP KU55933 is a potent radiosensitizer in vitro using clonogenic assay and is more effective as a radiosensitizer than free KU55933 in vivo using mouse xenograft models of non-small cell lung cancer (NSCLC). Western blots and immunofluorescence showed NP KU55933 exhibited more prolonged inhibition of DNA repair pathway. In addition, NP KU55933 leads to lower skin toxicity than KU55933. Our study supports further investigations using NP to deliver DSBRIs to improve cancer radiotherapy treatment.
Direct high-precision measurement of the magnetic moment of the proton
Creators: name: Mooser, A.
name: Ulmer, S.
name: Blaum, K.
name: Franke, K.
name: Kracke, H.
name: Leiteritz, C.
name: Quint, W.
name: Rodegheri, C. C.
name: Smorra, C.
name: Walz, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The spin-magnetic moment of the proton $μ_p$ is a fundamental property of this particle. So far $μ_p$ has only been measured indirectly, analysing the spectrum of an atomic hydrogen maser in a magnetic field. Here, we report the direct high-precision measurement of the magnetic moment of a single proton using the double Penning-trap technique. We drive proton-spin quantum jumps by a magnetic radio-frequency field in a Penning trap with a homogeneous magnetic field. The induced spin-transitions are detected in a second trap with a strong superimposed magnetic inhomogeneity. This enables the measurement of the spin-flip probability as a function of the drive frequency. In each measurement the proton's cyclotron frequency is used to determine the magnetic field of the trap. From the normalized resonance curve, we extract the particle's magnetic moment in units of the nuclear magneton $μ_p=2.792847350(9)μ_N$. This measurement outperforms previous Penning trap measurements in terms of precision by a factor of about 760. It improves the precision of the forty year old indirect measurement, in which significant theoretical bound state corrections were required to obtain $μ_p$, by a factor of 3. By application of this method to the antiproton magnetic moment $μ_{\bar{p}}$ the fractional precision of the recently reported value can be improved by a factor of at least 1000. Combined with the present result, this will provide a stringent test of matter/antimatter symmetry with baryons.
description: published in Nature
Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity
Creators: name: Sethi, Manish
name: Zhang, Ying-Ao
name: Wagner, Kyle T.
name: Wang, Edina
name: Wang, Andrew Z.
name: Tian, Xi
name: Caster, Joseph M.
name: Kowalczyk, Sonya
name: Nabeel Hyder, Sayed
name: Man Au, Kin
name: Kapadia, Chintan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We demonstrate proof of principle that nanoparticle delivery of chemosensitizers can improve efficacy of chemotherapy without increasing toxicity.
Additional file 1 of Efficacy and safety of JAK inhibitors in the treatment of psoriasis and psoriatic arthritis: a systematic review and meta-analysis
Creators: name: Sarabia, Samantha
name: Ranjith, Brandan
name: Koppikar, Sahil
name: Wijeratne, Don Thiwanka
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file1: Table S1. Raw data for outcomes.
Carbon nanotube electron field emitters for x-ray imaging of human breast cancer
Creators: name: Zhou, Otto
name: Shan, Jing
name: Lu, Jianping
name: Gao, Bo
name: Inscoe, Christy
name: Gidcumb, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: For imaging human breast cancer, digital breast tomosynthesis (DBT) has been shown to improve image quality and breast cancer detection in comparison to 2D mammography. Current DBT systems have limited spatial resolution and lengthy scan times. Stationary digital breast tomosynthesis (s-DBT), utilizing an array of carbon nanotube (CNT) field emission X-ray sources, provides increased spatial resolution and potentially faster imaging than current DBT systems. This study presents the results of detailed evaluations of CNT cathodes for X-ray breast imaging tasks. The following were investigated: high current, long-term stability of CNT cathodes for DBT; feasibility of using CNT cathodes to perform a 2D radiograph function; and cathode performance through several years of imaging. Results show that a breast tomosynthesis system using CNT cathodes could run far beyond the experimentally tested lifetime of one to two years. CNT cathodes were found capable of producing higher currents than typical DBT would require, indicating that the s-DBT imaging time can be further reduced. The feasibility of using a single cathode of the s-DBT tube to perform 2D mammography in 4 seconds, was demonstrated. Over the lifetime of the prototype s-DBT system, it was found that both cathode performance and transmission rate were stable and consistent.
Building User-Facing Platforms with Container Orchestration
Creators: name: Kincl, Jason
Publisher: name: Zenodo
Year: 2022

description: High performance computing has always offered batch computing services but demand is growing for a wider range of workflow and data services. Container orchestration is a perfect candidate for offering scheduling services for these types of workloads in a similar way. By leveraging container orchestration with Kubernetes, you can build a platform that includes both a service catalog and lets users run their own containerized services directly. The power of such a platform is being able to stand on the shoulders of giants. This starts with leveraging Kubernetes for container orchestration and running these types of workloads. Next is using the internal Kubernetes’ paradigms with Operators to provide higher level scheduling of specific types of applications to create a service catalog. Third is using the Kubernetes API to tie everything together under a single user experience.
Ultra-relativistic thermal production of electrons and positrons
Creators: name: Beesley, Jonathan Jacob
Publisher: name: Imperial College London
Year: 2022

description: This thesis investigates ultra-relativistic processes of thermal production of electrons and positrons, and the theories involved in their description. It first focuses on collisional ionisation and excitation rates in a partially-ionised plasma, presenting correction factors to them that account for special relativity in the free electron motion as a function of temperature and the threshold energy. These results are extended to de-excitation and three body recombination using detailed balance. It then turns to the production of electron-positron pairs from Breit-Wheeler two-photon collision in the black-body field, and presents an analytic expression for the high-temperature limit of the total rate. It then examines the same physical process using the formalism of "external fields", in which the black-body is treated as as a thermal ensemble of classical field profiles. It presents a novel formal scheme for this calculation, and then presents the results of a numerical scheme that approximates this field ensemble by 1D spatial "Sauter pulses". It is found that pair-production calculated by this means exceeds that calculated by Breit-Wheeler by a large factor, and the energy spectrum of produced particles is presented. Then, work comparing different theoretical formalisms of vacuum-destabilising background fields in QED is presented. It is first shown how solving the Dirac equation with peculiar boundary conditions can give probability amplitudes for fermion scattering and pair creation/annihilation. It is then demonstrated for a broad class of external fields that four fermion propagators used in the literature are equivalent: Schwinger’s "proper-time” propagator; the "causal propagator” used in the "Bogoliubov transformation” method; and two defined using analytic continuation. To do so, we re-derive Schwinger’s proper-time expression for the propagator as a statement relating solutions of the inhomogeneous Dirac equation to those of the inhomogeneous "proper-time Dirac equation”. We then show that all four propagators return solutions of the inhomogeneous Dirac equation that satisfy the same boundary condition.
Thickness dependence of dynamic and static magnetic properties of pulsed laser deposited La$_{0.7}$Sr$_{0.3}$MnO$_3$ films on SrTiO$_3$(001)
Creators: name: Monsen, Åsmund
name: Boschker, Jos E.
name: Macià, Ferran
name: Wells, Justin W.
name: Nordblad, Per
name: Kent, Andrew D.
name: Mathieu, Roland
name: Tybell, Thomas
name: Wahlström, Erik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a comprehensive study of the thickness dependence of static and magneto-dynamic magnetic properties of La$_{0.7}$Sr$_{0.3}$MnO$_3$. Epitaxial pulsed laser deposited La$_{0.7}$Sr$_{0.3}$MnO$_3$ / SrTiO$_3$(001) thin films in the range from 3 unit cells (uc) to 40 uc (1.2 - 16 nm) have been investigated through ferromagnetic resonance spectroscopy (FMR) and SQUID magnetometry at variable temperature. Magnetodynamically, three different thickness, $d$, regimes are identified: 20 uc $\lesssim d$ uc where the system is bulk like, a transition region 8 uc $\le d \lesssim 20$ uc where the FMR line width and position depend on thickness and $d=6$ uc which displays significantly altered magnetodynamic properties, while still displaying bulk magnetization. Magnetization and FMR measurements are consistent with a nonmagnetic volume corresponding to $\sim$ 4 uc. We observe a reduction of Curie temperature ($T_C$) with decreasing thickness, which is coherent with a mean field model description. The reduced ordering temperature also accounts for the thickness dependence of the magnetic anisotropy constants and resonance fields. The damping of the system is strongly thickness dependent, and is for thin films dominated by thickness dependent anisotropies, yielding both a strong 2-magnon scattering close to $T_c$ and a low temperature broadening. For the bulk like samples a large part of the broadening can be linked to spread in magnetic anisotropies attributed to crystal imperfections/domain boundaries of the bulk like film.
Additional file 2 of Efficacy and safety of JAK inhibitors in the treatment of psoriasis and psoriatic arthritis: a systematic review and meta-analysis
Creators: name: Sarabia, Samantha
name: Ranjith, Brandan
name: Koppikar, Sahil
name: Wijeratne, Don Thiwanka
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file2: Table S2. Summary of research question
On the analysis of island shape evolution from diffuse x-ray scattering of organic thin films and the implications for growth
Creators: name: Frank, C.
name: Banerjee, R.
name: Oettel, M.
name: Gerlach, A.
name: Novák, J.
name: Santoro, G.
name: Schreiber, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Understanding the growth of organic semi-conducting molecules with shape anisotropy is of high relevance to the processing of optoelectronic devices. This work provides insight into the growth of thin films of the prototypical rodlike organic semiconductor diindenoperylene on a microscopic level, by analyzing in detail the film morphology. We model our data, which were obtained by high-resolution grazing incidence small angle x-ray scattering (GISAXS), using a theoretical description from small angle scattering theory derived for simple liquids. Based on form factor calculations for different object types we determine how the island shapes change in the respective layers. Atomic force microscopy measurements approve our findings.
description: 11 pages, 7 figures, accepted by Phys. Rev. B
Aquatic invertebrates and waterbirds of wetlands and rivers of the southern Carnarvon Basin, Western Australia
Creators: name: Halse, S. A
name: Shiel, R. J
name: Storey, A. W
name: Edward, D. H. D
name: Lansbury, I
name: Cale, D. J
name: Harvey, M. S
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

Fifty-six sites, representing 53 wetlands, were surveyed in the southern Carnarvon Basin in 1994 and 1995 with the aim of documenting the waterbird and aquatic invertebrate fauna of the region. Most sites were surveyed in both winter and summer, although some contained water only one occasion. Altogether 57 waterbird species were recorded, with 29 292 waterbirds of 25 species on Lake MacLeod in October 1994. River pools were shown to be relatively important for waterbirds, while many freshwater claypans were little used.At least 492 species of aquatic invertebrate were collected. The invertebrate fauna was characterized by the low frequency with which taxa occurred: a third of the species were collected at a single site on only one occasion. Patterns of occurrence were not strongly seasonal. Many undescribed species were found and many range extensions were recorded, reflecting lack of endemicity could not be assessed adequately, although it is probably comparatively low. In terms of their invertebrate fauna, five types of wetlands were distinguished: river pools, rock pools and larger flowing streams; seeps, springs and smaller creeks; freshwater claypans; birridas; and Lake Macleod. Environmental factors to which invertebrates appeared to respond were ratio of calcium / alkalinity, total dissolved solids, turbidity, colour, flow, longitude and nutrients, although some factors were inter-correlated.Additional surveys should find extra species of waterbird and, more particularly, aquatic invertebrate using wetlands of the southern Carnarvon Basin. For many invertebrates, occurrences are too sparse for effective protection of species within a nature reserve system and other mechanisms will be required to ensure their conservation. Comparison of site classifications based on waterbird, aquatic invertebrate and plant data (Gibson et al., 2000) showed patterns among sites identified using one element of the biota did not reflect patterns shown by other elements. This suggests that, until further work has identified an element that reflects the whole wetland community, as many biotic elements as possible should be surveyed.
Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts
Creators: name: Chastain, Paul D.
name: Nikolaishvili-Feinberg, Nana
name: Prasad, Raju Y.
name: Smeester, Lisa
name: Kaufmann, William K.
name: Fry, Rebecca C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The use of nanoparticles in consumer products increases their prevalence in the environment and the potential risk to human health. Although recent studies have shown in vivo and in vitro toxicity of titanium dioxide nanoparticles (nano-TiO2), a more detailed view of the underlying mechanisms of this response needs to be established. Here the effects of nano-TiO2 on the DNA damage response and DNA replication dynamics were investigated in human dermal fibroblasts. Specifically, the relationship between nano-TiO2 and the DNA damage response pathways regulated by ATM/Chk2 and ATR/Chk1 were examined. The results show increased phosphorylation of H2AX, ATM, and Chk2 after exposure. In addition, nano-TiO2 inhibited the overall rate of DNA synthesis and frequency of replicon initiation events in DNA combed fibers. Taken together, these results demonstrate that exposure to nano-TiO2 activates the ATM/Chk2 DNA damage response pathway.
Assessing Technical Performance in Differential Gene Expression Experiments with External Spike-in RNA Control Ratio Mixtures
Creators: name: Munro, Sarah A.
name: Lund, Steve P.
name: Pine, P. Scott
name: Binder, Hans
name: Clevert, Djork-Arné
name: Conesa, Ana
name: Dopazo, Joaquin
name: Fasold, Mario
name: Hochreiter, Sepp
name: Hong, Huixiao
name: Jafari, Nederah
name: Kreil, David P.
name: Łabaj, Paweł P.
name: Li, Sheng
name: Liao, Yang
name: Lin, Simon
name: Meehan, Joseph
name: Mason, Christopher E.
name: Santoyo, Javier
name: Setterquist, Robert A.
name: Shi, Leming
name: Shi, Wei
name: Smyth, Gordon K.
name: Stralis-Pavese, Nancy
name: Su, Zhenqiang
name: Tong, Weida
name: Wang, Charles
name: Wang, Jian
name: Xu, Joshua
name: Ye, Zhan
name: Yang, Yong
name: Yu, Ying
name: Salit, Marc
Publisher: name: arXiv
Year: 2014
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: There is a critical need for standard approaches to assess, report, and compare the technical performance of genome-scale differential gene expression experiments. We assess technical performance with a proposed "standard" dashboard of metrics derived from analysis of external spike-in RNA control ratio mixtures. These control ratio mixtures with defined abundance ratios enable assessment of diagnostic performance of differentially expressed transcript lists, limit of detection of ratio (LODR) estimates, and expression ratio variability and measurement bias. The performance metrics suite is applicable to analysis of a typical experiment, and here we also apply these metrics to evaluate technical performance among laboratories. An interlaboratory study using identical samples shared amongst 12 laboratories with three different measurement processes demonstrated generally consistent diagnostic power across 11 laboratories. Ratio measurement variability and bias were also comparable amongst laboratories for the same measurement process. Different biases were observed for measurement processes using different mRNA enrichment protocols.
description: 65 pages, 6 Main Figures, 33 Supplementary Figures
Cross-View Visual Geo-Localization for Outdoor Augmented Reality
Creators: name: Mithun, Niluthpol Chowdhury
name: Minhas, Kshitij
name: Chiu, Han-Pang
name: Oskiper, Taragay
name: Sizintsev, Mikhail
name: Samarasekera, Supun
name: Kumar, Rakesh
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: Precise estimation of global orientation and location is critical to ensure a compelling outdoor Augmented Reality (AR) experience. We address the problem of geo-pose estimation by cross-view matching of query ground images to a geo-referenced aerial satellite image database. Recently, neural network-based methods have shown state-of-the-art performance in cross-view matching. However, most of the prior works focus only on location estimation, ignoring orientation, which cannot meet the requirements in outdoor AR applications. We propose a new transformer neural network-based model and a modified triplet ranking loss for joint location and orientation estimation. Experiments on several benchmark cross-view geo-localization datasets show that our model achieves state-of-the-art performance. Furthermore, we present an approach to extend the single image query-based geo-localization approach by utilizing temporal information from a navigation pipeline for robust continuous geo-localization. Experimentation on several large-scale real-world video sequences demonstrates that our approach enables high-precision and stable AR insertion.
description: IEEE VR 2023
Point contact investigations of film and interface magnetoresistance of La$_{0.7}$Sr$_{0.3}$MnO$_3$ heterostructures on Nb:SrTiO$_{3}$
Creators: name: Monsen, Asmund
name: Boschker, Jos E.
name: Nordblad, Per
name: Mathieu, Roland
name: Tybell, Thomas
name: Wahlström, Erik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: STM based magnetotransport measurements of epitaxial La$_{0.7}$Sr$_{0.3}$MnO$_3$ 32 nm thick films with and without an internal LaMnO$_3$ layer (0-8 nm thick) grown on Nb doped SrTiO$_3$ are presented. The measurements reveal two types of low field magnetoresistance (LFMR) with a magnitude of $\sim 0.1-1.5\%$. One LFMR contribution is identified as a conventional grain boundary/domain wall scattering through the symmetric I-V characteristics, high dependence on tip placements and insensitivity to introduction of LaMnO$_3$ layers. The other contribution originates from the reverse biased Nb doped SrTiO$_3$ interface and the interface layer of La$_{0.7}$Sr$_{0.3}$MnO$_3$. Both LFMR contributions display a field dependence indicative of a higher coercivity ($\sim$200 Oe) than the bulk film. LaMnO$_3$ layers are found to reduce the rectifying properties of the junctions, and sub micron lateral patterning by electron beam lithography enhances the diodic properties, in accordance with a proposed transport model based on the locality of the injected current.
On the calibration of direct-current current transformers
Creators: name: Callegaro, Luca
name: Cassiago, Cristina
name: Gasparotto, Enrico
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Modern commercial direct-current current transformers (DCCT) can measure currents up to the kA range with accuracies better than 1E-5. We discuss here a DCCT calibration method and its implementation with commercial instruments typically employed in low resistance calibration laboratories. The primary current ranges up to 2 kA; in the current range below \SI{100}{\ampere} the calibration uncertainty is better than 3E-7. An example of calibration of a high-performance DCCT specified for primary currents measurement up to 900 A is discussed in detail.
description: Accepted for publication in IEEE Trans. Instr. Meas. Copyright IEEE
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1993
Subjects: Community/Rural/Urban Development

description: Overview: Rural Employment Recovering Slowly, Earnings Gap Widens; National Economic Conditions, Slow Growth Continues; Employment: Moderate, Uneven Gains For Rural Employment; Unemployment: Decline in Rural Unemployment Stalls in the Second Quarter of 1993; Industry: Rural Jobs Withstood the 1990-91 Recession Better Than Urban Jobs; Earnings: Effects of 1990-91 Recession on Rural Earnings Were Comparatively Mild; Appendix Data Sources and Definitions; Appendix Tables
Additional file 3 of Efficacy and safety of JAK inhibitors in the treatment of psoriasis and psoriatic arthritis: a systematic review and meta-analysis
Creators: name: Sarabia, Samantha
name: Ranjith, Brandan
name: Koppikar, Sahil
name: Wijeratne, Don Thiwanka
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file3: Fig. S1. Funnel plot for studies that include 75% improvement in the Psoriasis area and severilty index (PASI75) as an outcome
Cytotoxic and Anti-HIV Phenanthroindolizidine Alkaloids from Cryptocarya chinensis
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(−)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3–7), and four proaporphine alkaloids (8–11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 μg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.
Setup and Analysis of BetP µs-long simulations
Creators: name: Leone, Vanessa
name: Bradshaw, Richard T
name: Koshy, Caroline
name: Lee, Paul Suhwan
name: Forrest, Lucy R
Publisher: name: Zenodo
Year: 2021
Subjects: Secondary Transporter
Membrane protein
BetP
Molecular Dynamics Simulations

description: Equilibration information and analysis data of BetP simulations presented in XXX manuscript. equilibration-steps.docx - Equilibration steps of simulations derived from the crystal structure (inclined) and from the cryo-electron microscopy (EM) data (flat) embedded in an hydrated 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol bilayer. contact-prot-ions-inclined.xvg - Xmgrace file to plot the count of contacts between the BetP trimer derived from the crystal structure and sodium and potassium ions contact-prot-prot-inclined.xvg - Xmgrace file to plot the count of protein-protein contacts of the BetP trimer derived from the crystal structure contact-prot-ions-flat.xvg - Xmgrace file to plot the count of contacts between the BetP trimer derived from the EM data and sodium and potassium ions contact-prot-prot-flat.xvg - Xmgrace file to plot the count of protein-protein contacts of the BetP trimer derived from the EM data
Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents
Creators: name: Qian, Keduo
name: Lee, Kuo-Hsiung
name: Kuo, Reen-Yen
name: Morris-Natschke, Susan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: This article reviews the antitumor and anti-HIV activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane, lanostane, dammarane, and miscellaneous scaffolds. Structure–activity relationships of selected natural compounds and their synthetic derivatives are also discussed.
การพัฒนาแผนการจัดการเรียนรู้ เรื่อง หลักการนับเบื้องต้น โดยใช้เทคนิคเค ดับเบิ้ลยู ดี แอลร่วมกับแบบฝึกทักษะ ชั้นมัธยมศึกษาปีที่ 4
Creators: name: หัทยา สำนักบ้านโคก
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยกาฬสินธุ์
Year: 2023
Subjects: การพัฒนาแผนการจัดการเรียนรู้
เทคนิคเค ดับเบิ้ลยู ดี แอล
แบบฝึกทักษะ

description: วารสารมนุษยศาสตร์ สังคมศาสตร์ และนวัตกรรม มหาวิทยาลัยกาฬสินธุ์, 2, 1, 1-13
A microRNA polycistron as a potential human oncogene
Creators: name: Goodson, Summer
name: Powers, Scott
name: Cordon-Cardo, Carlos
name: He, Lin
name: Hernando-Monge, Eva
name: Mu, David
name: Hannon, Gregory J.
name: Hemann, Michael T.
name: Thomson, J. Michael
name: Hammond, Scott M.
name: Lowe, Scott W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17–92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas1. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in these cancers. Enforced expression of the mir-17–92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17–92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17–92 cluster as a potential human oncogene.
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70
Creators: name: Qian, Shu-Bing
name: Boellmann, Frank
name: McDonough, Holly
name: Patterson, Cam
name: Cyr, Douglas M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Exposure of cells to various stresses often leads to the induction of a group of proteins called heat shock proteins (HSPs, molecular chaperones)1,2. Hsp70 is one of the most highly inducible molecular chaperones, but its expression must be maintained at low levels under physiological conditions to permit constitutive cellular activities to proceed3,4. Heat shock transcription factor 1 (HSF1) is the transcriptional regulator of HSP gene expression5, but it remains poorly understood how newly synthesized HSPs return to basal levels when HSF1 activity is attenuated. CHIP (carboxy terminus of Hsp70-binding protein), a dual-function co-chaperone/ubiquitin ligase, targets a broad range of chaperone substrates for proteasomal degradation6–11. Here we show that CHIP not only enhances Hsp70 induction during acute stress but also mediates its turnover during the stress recovery process. Central to this dual-phase regulation is its substrate dependence: CHIP preferentially ubiquitinates chaperone-bound substrates, whereas degradation of Hsp70 by CHIP-dependent targeting to the ubiquitin–proteasome system occurs when misfolded substrates have been depleted. The sequential catalysis of the CHIP-associated chaperone adaptor and its bound substrate provides an elegant mechanism for maintaining homeostasis by tuning chaperone levels appropriately to reflect the status of protein folding within the cytoplasm.
Increasing p16INK4aexpression decreases forebrain progenitors and neurogenesis during ageing
Creators: name: Pardal, Ricardo
name: Slutsky, Shalom G.
name: He, Shenghui
name: Sharpless, Norman E.
name: Joseph, Nancy M.
name: Krishnamurthy, Janakiraman
name: Molofsky, Anna V.
name: Morrison, Sean J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells1,2. It has been proposed that this is at least partially caused by the senescence of progenitors with age3,4; however, it has not yet been tested whether genes associated with senescence functionally contribute to physiological declines in progenitor activity. Here we show that progenitor proliferation in the subventricular zone and neurogenesis in the olfactory bulb, as well as multipotent progenitor frequency and self-renewal potential, all decline with age in the mouse forebrain. These declines in progenitor frequency and function correlate with increased expression of p16INK4a, which encodes a cyclin-dependent kinase inhibitor linked to senescence5. Ageing p16INK4a-deficient mice showed a significantly smaller decline in subventricular zone proliferation, olfactory bulb neurogenesis, and the frequency and self-renewal potential of multipotent progenitors. p16INK4a deficiency did not detectably affect progenitor function in the dentate gyrus or enteric nervous system, indicating regional differences in the response of neural progenitors to increased p16INK4a expression during ageing. Declining subventricular zone progenitor function and olfactory bulb neurogenesis during ageing are thus caused partly by increasing p16INK4a expression.
LHC Tests of Light Neutralino Dark Matter without Light Sfermions
Creators: name: Calibbi, Lorenzo
name: Lindert, Jonas M.
name: Ota, Toshihiko
name: Takanishi, Yasutaka
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We address the question how light the lightest MSSM neutralino can be as dark matter candidate in a scenario where all supersymmetric scalar particles are heavy. The hypothesis that the neutralino accounts for the observed dark matter density sets strong requirements on the supersymmetric spectrum, thus providing an handle for collider tests. In particular for a lightest neutralino below 100 GeV the relic density constraint translates into an upper bound on the Higgsino mass parameter $μ$ in case all supersymmetric scalar particles are heavy. One can define a simplified model that highlights only the necessary features of the spectrum and their observable consequences at the LHC. Reinterpreting recent searches at the LHC we derive limits on the mass of the lightest neutralino that, in many cases, prove to be more constraining than dark matter experiments themselves.
description: 22 pages, 8 figures
Additional file 4 of Efficacy and safety of JAK inhibitors in the treatment of psoriasis and psoriatic arthritis: a systematic review and meta-analysis
Creators: name: Sarabia, Samantha
name: Ranjith, Brandan
name: Koppikar, Sahil
name: Wijeratne, Don Thiwanka
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file4: Fig.S2 Funnel plot for studies that included 20% improvement in the American college of Rheumatology composite score (ACR20) as an outcome
Early 56Ni decay γ-rays from SN2014J suggest an unusual explosion
Creators: name: Diehl, Roland
name: Siegert, Thomas
name: Hillebrandt, Wolfgang
name: Grebenev, Sergei A.
name: Greiner, Jochen
name: Krause, Martin
name: Kromer, Markus
name: Maeda, Keiichi
name: Roepke, Friedrich
name: Taubenberger, Stefan
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Type-Ia supernovae result from binary systems that include a carbon-oxygen white dwarf, and these thermonuclear explosions typically produce 0.5 M_solar of radioactive 56Ni. The 56Ni is commonly believed to be buried deeply in the expanding supernova cloud. Surprisingly, in SN2014J we detected the lines at 158 and 812 keV from 56Ni decay (τ~8.8 days) earlier than the expected several-week time scale, only ~20 days after the explosion, and with flux levels corresponding to roughly 10% of the total expected amount of 56Ni. Some mechanism must break the spherical symmetry of the supernova, and at the same time create a major amount of 56Ni at the outskirts. A plausible explanation is that a belt of helium from the companion star is accreted by the white dwarf, where this material explodes and then triggers the supernova event.
description: 7 pages, 3 figures; submitted 10 Apr 2014; accepted 21 Jul 2014 (www.sciencemag.org)
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Creators: name: Chen, Meng
name: Calakos, Nicole
name: Wetsel, William C.
name: Welch, Jeffrey M.
name: Adams, J. Paige
name: Trotta, Nicholas C.
name: Luo, Jianhong
name: Ding, Jin-Dong
name: Weinberg, Richard J.
name: Dudek, Serena M.
name: Feng, Guoping
name: Lu, Jing
name: Feliciano, Catia
name: Rodriguiz, Ramona M.
name: Peca, Joao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated in OCD, though the underlying pathogenic mechanisms are unknown. SAP90/PSD95-associated protein 3 (SAPAP3) is a postsynaptic scaffolding protein at excitatory synapses that is highly expressed in the striatum. Here we show that mice with genetic deletion of SAPAP3 exhibit increased anxiety and compulsive grooming behavior leading to facial hair loss and skin lesions; both behaviors are alleviated by a selective serotonin reuptake inhibitor. Electrophysiological, structural, and biochemical studies of SAPAP3 mutant mice reveal defects in cortico-striatal synapses. Furthermore, lentiviral-mediated selective expression of SAPAP3 in the striatum rescues the synaptic and behavioral defects of SAPAP3 mutant mice. These findings demonstrate a critical role for SAPAP3 at cortico-striatal synapses and emphasize the importance of cortico-striatal circuitry in OCD-like behaviors.
Additional file 1 of Barriers and facilitators for implementation of a digital referral algorithm for inflammatory arthritis - a qualitative assessment in patients and caregivers
Creators: name: van Delft, Elke
name: Bos, Ruben
name: Pennings, Patricia
name: Hazes, Mieke
name: Lopes Barreto, Deirisa
name: Weel-Koenders, Angelique
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Additional file 1.
Nonlocal correlations in the star-network configuration
Creators: name: Tavakoli, Armin
name: Skrzypczyk, Paul
name: Cavalcanti, Daniel
name: Acín, Antonio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The concept of bilocality was introduced to study the correlations which arise in an entanglement swapping scenario, where one has two sources which can naturally taken to be independent. This additional constraint leads to stricter requirements than simply imposing locality, in the form of bilocality inequalities. In this work we consider a natural generalisation of the bilocality scenario, namely the star-network consisting of a single central party surrounded by $n$ edge parties, each of which shares an independent source with the centre. We derive new inequalities which are satisfied by all local correlations in this scenario, for the cases when the central party performs (i) two dichotomic measurements (ii) a single Bell state measurement. We demonstrate quantum violations of these inequalities and study both the robustness to noise and to losses.
description: 12 pages, 2 figures
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
Creators: name: Clelland, Gayle K.
name: Taylor, Christopher M.
name: Asthana, Saurabh
name: Stamatoyannopoulos, John A.
name: Snyder, Michael
name: Birney, Ewan
name: Malhotra, Ankit
name: Dorschner, Michael O.
name: Day, Nathan
name: Kuehn, Michael S.
name: Stamatoyannopoulos, John A.
name: Gingeras, Thomas R.
name: Cao, Hua
name: Weng, Zhiping
name: Dhami, Pawandeep
name: Neph, Shane
name: Carter, Nigel P.
name: Dutta, Anindya
name: Davis, Sean
name: Flicek, Paul
name: Giresi, Paul G.
name: Guigó, Roderic
name: Dermitzakis, Emmanouil T.
name: Adzhubei, Ivan
name: Boyle, Patrick J.
name: Koch, Christoph M.
name: Greenbaum, Jason A.
name: Thurman, Robert E.
name: Dillon, Shane C.
name: Andrews, Robert M.
name: Fiegler, Heike
name: Margulies, Elliott H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view about chromatin structure has emerged, including its interrelationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded novel mechanistic and evolutionary insights about the functional landscape of the human genome. Together, these studies are defining a path forward to pursue a more-comprehensive characterisation of human genome function.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Nel presente articolo si traccia il profilo di Donata Doni, una poetessa romagnola di origini lucane, a distanza di cinquant’anni dalla sua scomparsa. Pur trattandosi di una figura esclusa dal canone letterario novecentesco, Donata Doni è autrice di una produzione poetica abbastanza copiosa, anche se in parte ancora inedita. L’articolo si sofferma sulla produzione poetica edita, registrandone la ricezione critica.
description: In the article it is drawn the profile of Donata Doni, a poet from Romagna with Lucanian origins, fifty years after her death. Although she is a figure excluded from the twentieth-century literary canon, Donata Doni is the author of a large enough poetic production, even though it is still partly unpublished. The article dwells on her published poetic production, recording its critical reception.