cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structure-inspired Ansatz and Warm Start of Variational Quantum Algorithms for Quadratic Unconstrained Binary Optimization Problems
Creators: name: Chai, Yahui
name: Jansen, Karl
name: Kühn, Stefan
name: Schwägerl, Tim
name: Stollenwerk, Tobias
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2024

description: This paper introduces a structure-inspired ansatz for addressing quadratic unconstrained binary optimization problems with the Variational Quantum Eigensolver. We propose a novel warm start technique that is based on imaginary time evolution, and allows for determining a set of initial parameters prioritizing lower energy states in a resource-efficient way. Using classical simulations, we demonstrate that this warm start method significantly improves the success rate and reduces the number of iterations required for the convergence of Variational Quantum Eigensolver. The numerical results also indicate that the warm start approach effectively mitigates statistical errors arising from a finite number of measurements, and to a certain extent alleviates the effect of barren plateaus.
Supplementary_file_1 - B-Lines Scores Derived From Lung Ultrasound Provide Accurate Prediction of Extravascular Lung Water Index: An Observational Study in Critically Ill Patients
Creators: name: Mayr, Ulrich
name: Lukas, Marina
name: Habenicht, Livia
name: Wiessner, Johannes
name: Heilmaier, Markus
name: Ulrich, Jörg
name: Rasch, Sebastian
name: Schmid, Roland M.
name: Lahmer, Tobias
name: Huber, Wolfgang
name: Herner, Alexander
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplementary_file_1 for B-Lines Scores Derived From Lung Ultrasound Provide Accurate Prediction of Extravascular Lung Water Index: An Observational Study in Critically Ill Patients by Ulrich Mayr, Marina Lukas, Livia Habenicht, Johannes Wiessner, Markus Heilmaier, Jörg Ulrich, Sebastian Rasch, Roland M. Schmid, Tobias Lahmer, Wolfgang Huber and Alexander Herner in Journal of Intensive Care Medicine
Arabidopsis plant natriuretic peptide is a novel interactor of rubisco activase
Creators: name: Turek, Ilona
name: C Gehring
name: Irving, Helen
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Plant natriuretic peptides (PNPs) are a group of systemically acting peptidic hormones affecting solute and solvent homeostasis and responses to biotrophic pathogens. Although an increasing body of evidence suggests PNPs modulate plant responses to biotic and abiotic stress, which could lead to their potential biotechnological application by conferring increased stress tolerance to plants, the exact mode of PNPs action is still elusive. In order to gain insight into PNP-dependent signalling, we set out to identify interactors of PNP present in the model plant Arabidopsis thaliana, termed AtPNP-A. Here, we report identification of rubisco activase (RCA), a central regulator of photosynthesis converting Rubisco catalytic sites from a closed to an open conformation, as an interactor of AtPNP-A through affinity isolation followed by mass spectrometric identification. Surface plasmon resonance (SPR) analyses reveals that the full-length recombinant AtPNP-A and the biologically active fragment of AtPNP-A bind specifically to RCA, whereas a biologically inactive scrambled peptide fails to bind. These results are considered in the light of known functions of PNPs, PNP-like proteins, and RCA in biotic and abiotic stress responses.
Separation of crude methanol extract of Plantago major root: identification of phytochemicals and assessment of biological activities
Creators: name: Rahamouz-Haghighi, Samaneh
name: Sharafi, Ali
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Plantago major root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichloromethane extract of P. major had the highest inhibitory effect against Salmonella paratyphi (18.00 ± 1.4 mm) at 100 mg/mL concentration. The lowest MIC was also achieved for S. paratyphi treated with dichloromethane extract of P. major (1.5 mg/mL). The minimum MBC (2 mg/mL) was observed for dichloromethane extract of P. major root against S. paratyphi. IC50 values of dichloromethane extracts of P. major root (184.84 μg/mL) against HCT116 were lower than the ethyl acetate and butanol extracts (212.41 μg/mL and 223.93 μg/mL) at 72h. The butanol extract exhibited the most IC50 value on HEK293 (748.19 μg/mL). The biological properties of P. major extracts may be assigned to the presence of numerous compounds detected in GC/MS analysis including n-Hexadecanoic acid, Linolenic acid, Palmitic acid, methyl ester, Stearic acid.
Additional file 1 of The use of sodium-glucose co-transporter-2 inhibitors or glucagon-like peptide-1 receptor agonists versus sulfonylureas and the risk of lower limb amputations: a nation-wide cohort study
Creators: name: Werkman, Nikki C. C.
name: Driessen, Johanna H. M.
name: Stehouwer, Coen D. A.
name: Vestergaard, Peter
name: Schaper, Nicolaas C.
name: van den Bergh, Joop P.
name: Nielen, Johannes T. H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Figure S1 Graphical depiction [23] of the analysis of the study cohort. Table S1 Risk of LLA, forefoot amputation and DFU in current use of different NIGLDs compared to DPP4-I use (sensitivity analysis 1). Table S2 Risk of LLA in current use of different NIGLDs compared to SU use excluding LLA history at baseline (sensitivity analysis 2).
Chitosan nanoparticles loaded with epigallocatechin-3-gallate: synthesis, characterisation, and effects against Streptococcus mutans biofilm
Creators: name: Aragão, Maria Gerusa Brito
name: Tedesco, Antônio Cláudio
name: Borges, Hiago Salge
name: Aires, Carolina Patrícia
name: Corona, Silmara Aparecida Milori
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study evaluated the effects of chitosan nanoparticles loaded with epigallocatechin-3-gallate (EGCG) against Streptococcus mutans biofilm. EGCG-loaded chitosan (Nchi + EGCG) nanoparticles and Chitosan (Nchi) nanoparticles were prepared by ion gelation process and characterised regarding particle size, polydispersion index, zeta potential, and accelerated stability. S mutans biofilms were treated twice daily with NaCl 0.9% (negative control), Nchi, Nchi + EGCG, and chlorhexidine (CHX) 0.12% (positive control). After 67 h, the biofilms were evaluated for acidogenesis, bacterial viability and dry weight. Biofilm morphology and structure were analysed by scanning electron microscopy. The nanoformulations presented medium to short-term stability, size of 500 nm, and polydispersion index around 0.400. Treatments affected cell morphology and biofilm structure. However, no effects on microbial viability, biofilm dry weight, and acidogenesis were observed. Thus, the nanoformulations disassembled the biofilm matrix without affecting microbial viability, which makes them promising candidates for the development of dental caries preventive and therapeutic agents.
Poxviral strategies to overcome host cell apoptosis
Creators: name: Chathura Suraweera
name: MG Hinds
name: Kvansakul, Marc
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Li-censee MDPI, Basel, Switzerland. Apoptosis is a form of cellular suicide initiated either via extracellular (extrinsic apoptosis) or intracellular (intrinsic apoptosis) cues. This form of programmed cell death plays a crucial role in development and tissue homeostasis in multicellular organisms and its dysregulation is an underlying cause for many diseases. Intrinsic apoptosis is regulated by members of the evolutionarily conserved B-cell lymphoma-2 (Bcl-2) family, a family that consists of pro-and anti-apoptotic members. Bcl-2 genes have also been assimilated by numerous viruses including pox viruses, in particular the sub-family of chordopoxviridae, a group of viruses known to infect almost all vertebrates. The viral Bcl-2 proteins are virulence factors and aid the evasion of host immune defenses by mimicking the activity of their cellular counterparts. Viral Bcl-2 genes have proved essential for the survival of virus infected cells and structural studies have shown that though they often share very little sequence identity with their cellular counterparts, they have near-identical 3D structures. However, their mechanisms of action are varied. In this review, we examine the structural biology, molecular interactions, and detailed mechanism of action of poxvirus encoded apoptosis inhibitors and how they impact on host–virus interactions to ultimately enable successful infection and propagation of viral infections.
A method of assessing rework for implementing software requirements changes
Creators: name: Shalinka Jayatilleke
name: Lai, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Software development is often affected by user/system requirements changes. To implement requirements changes, a system which is being developed needs to be reworked. However, the term “Rework” has not been clearly defined in the literature. Depending on the complexity of the changes, the amount of rework required varies from some software module modifications to a non-trivial alteration to the software design of a system. The effort associated with such a rework obviously will vary too. To date, there has been scant research on rework assessment, and the relationship between it and change effort estimation is hardly understood. In this paper, we present a definition for rework, and describe a method of assessing rework for implementing software requirements changes. Our method consists of three stages: Namely (i) change identification; (ii) change analysis; and (iii) rework assessment. To demonstrate the practicality that it enables developers to compare the rework between the different options available for implementing a requirements change and to identify the one which is less invasive and requires lesser amount of modifications to the software system design, we explain our concept with the use of a running example.
Additional file 1 of Worldwide variation in cardiovascular magnetic resonance practice models
Creators: name: Sierra-Galan, Lilia M.
name: Estrada-Lopez, Edgar E. S.
name: Ferrari, Victor A.
name: Raman, Subha V.
name: Ferreira, Vanessa M.
name: Raj, Vimaj
name: Joseph, Elizabeth
name: Schulz-Menger, Jeanette
name: Chan, Carmen W. S.
name: Chen, Sylvia S. M.
name: Cheng, Yuchen
name: De Lara Fernandez, Juliano
name: Terashima, Masahiro
name: Albert, Timothy S. E.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Figure S1. World maps. Color coding only indicates different regions. Table S1. SCMR membership distribution. Table S2. Respondents’ background. Table S3. CMR logistics. Table S4. CMR indications and referrals. Table S5. CMR main barriers. Figure S2. CMR main referring physicians segregated by High vs. Low volume center analysis. Figure S3. Community size of CMR service area segregated by High vs. Low volume center analysis.
Analysis of multi-hit crystals in serial synchrotron crystallography experiments using high-viscosity injectors
Creators: name: Jazi, Marjan Hadian
name: Berntsen, Peter
name: Marman, Hugh
name: Abbey, Brian
name: Darmanin, Connie
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Serial Synchrotron Crystallography (SSX) is rapidly emerging as a promising technique for collecting data for time-resolved structural studies or for performing room temperature microcrystallography measurements using micro-focused beamlines. SSX is often performed using high frame rate detectors in combination with continuous sample scanning or high-viscosity or liquid jet injectors. When performed using ultra-bright X-ray Free Electron Laser (XFEL) sources serial crystallography typically involves a process known as ’diffract-and-destroy’ where each crystal is measured just once before it is destroyed by the intense XFEL pulse. In SSX, however, particularly when using high-viscosity injectors (HVIs) such as Lipidico, the crystal can be intercepted multiple times by the X-ray beam prior to exiting the interaction region. This has a number of important consequences for SSX including whether these multiple-hits can be incorporated into the data analysis or whether they need to be excluded due to the potential impact of radiation damage. Here, we investigate the occurrence and characteristics of multiple hits on single crystals using SSX with lipidico. SSX data are collected from crystals as they tumble within a high viscous stream of silicone grease flowing through a micro-focused X-ray beam. We confirmed that, using the Eiger 16M, we are able to collect up to 42 frames of data from the same single crystal prior to it leaving the X-ray interaction region. The frequency and occurrence of multiple hits may be controlled by varying the sample flow rate and X-ray beam size. Calculations of the absorbed dose confirm that these crystals are likely to undergo radiation damage but that nonetheless incorporating multiple hits into damage-free data should lead to a significant reduction in the number of crystals required for structural analysis when compared to just looking at a single diffraction pattern from each crystal.
"One Specimen Many Stories", encouraging new visions and seldom heard voices about natural history specimens.
Creators: name: Marshall, Christopher
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on "One Specimen Many Stories", encouraging new visions and seldom heard voices about natural history specimens. by Curator, Oregon State Arthropod Collection Christopher Marshall of Curator, Oregon State Arthropod Collection Oregon State University, Dept. Integrative Biology Corvallis United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Two new compounds from biotransformation of glycyrrhetinic acid
Creators: name: Xie, Zehao
name: Gu, Xinxin
name: Dekebo, Aman
name: Wei, Shaozhong
name: Hu, Xuebo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology

description: Glycyrrhetinic acid may undergo biotransformation to obtain derivatives with stronger pharmacological activity and fewer side effects. This study used 19 fungi to biotransform glycyrrhetinic acid and yielded two compounds namely bicyclo(14.15.27)glycyrrhetinic acid (1) and 2-ene-glycyrrhetinic acid (2) from the glycyrrhetinic acid metabolites of two fungi, Botrytis cinerea B05.10 ATCC 11542 and Aspergillus ochraceopetaliformis ATCC 12066. Compound 1 inhibited HMEC-1 cell proliferation in a concentration-dependent manner (IC50=239.1 µ M), but showed no significant cytotoxicity to A549 cells.
Exercise-therapy and education for individuals one year after anterior cruciate ligament reconstruction: a pilot randomised controlled trial
Creators: name: Patterson, Brooke
name: Barton, Christian
name: Culvenor, Adam
name: RL Cooper
name: Crossley, Kay
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021, The Author(s). Background: Guided rehabilitation beyond 6-months is rare following anterior cruciate ligament reconstruction (ACLR), despite high prevalence of unacceptable symptoms and quality of life (QoL). Our primary aim was to determine the feasibility of a randomised controlled trial (RCT) evaluating a physiotherapist-guided intervention for individuals 1-year post-ACLR with persistent symptoms. Our secondary aim was to determine if a worthwhile treatment effect could be observed for the lower-limb focussed intervention (compared to the trunk-focussed intervention), for improvement in knee-related QoL, symptoms, and function. Design: Participant- and assessor-blinded, pilot feasibility RCT. Methods: Participant eligibility criteria: i) 12–15 months post-ACLR; ii) < 87.5/100 on the Knee injury and Osteoarthritis Outcome Score (KOOS) QoL subscale; and either a one-leg rise test < 22 repetitions, single-hop < 90% limb symmetry; or Anterior Knee Pain Scale < 87/100. Participants were randomised to lower-limb or trunk-focussed focussed exercise and education. Both interventions involved 8 face-to-face physiotherapy sessions over 16-weeks. Feasibility was assessed by eligibility rate (> 1 in 3 screened), recruitment rate (> 4 participants/month), retention (< 20% drop-out), physiotherapy attendance and unsupervised exercise adherence (> 80%). Between-group differences for knee-related QoL (KOOS-QoL, ACL-QoL), symptoms (KOOS-Pain, KOOS-Symptoms), and function (KOOS-Sport, functional performance tests) were used to verify that the worthwhile effect (greater than the minimal detectable change for each measure) was contained within the 95% confidence interval. Results: 47% of those screened were eligible, and 27 participants (3 participants/month; 48% men, 34±12 years) were randomised. Two did not commence treatment, and two were lost to follow-up (16% drop-out). Physiotherapy attendance was > 80% for both groups but reported adherence to unsupervised exercise was low (< 55%). Both interventions had potentially worthwhile effects for KOOS-QoL and ACL-QoL, while the lower-limb focussed intervention had potentially greater effects for KOOS-Sport, KOOS-Pain, and functional performance. Conclusions: A larger-scale RCT is warranted. All feasibility criteria were met, or reasonable recommendations could be made to achieve the criteria in future trials. Strategies to increase recruitment rate and exercise adherence are required. The potential worthwhile effects for knee-related QoL, symptoms, and function indicates a fully-powered RCT may detect a clinically meaningful effect. Trial registration: Prospectively registered (ACTRN12616000564459).
Supplemental Material, supplemental_table1 - Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia
Creators: name: Basavaraju, Rakshathi
name: Feng, Xinyang
name: France, Jeanelle
name: Huey, Edward D.
name: Provenzano, Frank A.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental Material, supplemental_table1 for Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia by Rakshathi Basavaraju, Xinyang Feng, Jeanelle France, Edward D. Huey and Frank A. Provenzano in Journal of Geriatric Psychiatry and Neurology
Supplemental Material, visual_qc_01 - Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia
Creators: name: Basavaraju, Rakshathi
name: Feng, Xinyang
name: France, Jeanelle
name: Huey, Edward D.
name: Provenzano, Frank A.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental Material, visual_qc_01 for Depression Is Associated With Preserved Cortical Thickness Relative to Apathy in Frontotemporal Dementia by Rakshathi Basavaraju, Xinyang Feng, Jeanelle France, Edward D. Huey and Frank A. Provenzano in Journal of Geriatric Psychiatry and Neurology
Supplementary_Table_1 - Changes in Self- and Informant-Reported Frontal Behaviors in Parkinson’s Disease: A Longitudinal Study
Creators: name: Pluim, Celina F.
name: Nakhla, Marina Z.
name: Split, Molly
name: Filoteo, J. Vincent
name: Litvan, Irene
name: Moore, Raeanne C.
name: Lessig, Stephanie
name: Schiehser, Dawn M.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplementary_Table_1 for Changes in Self- and Informant-Reported Frontal Behaviors in Parkinson’s Disease: A Longitudinal Study by Celina F. Pluim, Marina Z. Nakhla, Molly Split, J. Vincent Filoteo, Irene Litvan, Raeanne C. Moore, Stephanie Lessig and Dawn M. Schiehser in Journal of Geriatric Psychiatry and Neurology
Shock damage analysis in serial femtosecond crystallography data collected at MHz X-ray free-electron lasers
Creators: name: A Gorel
name: ML Grünbein
name: R Bean
name: J Bielecki
name: M Hilpert
name: M Cascella
name: JP Colletier
name: H Fangohr
name: L Foucar
name: E Hartmann
name: MS Hunter
name: Kirkwood, Henry
name: M Kloos
name: R Letrun
name: T Michelat
name: RL Shoeman
name: J Sztuk-Dambietz
name: G Tetreau
name: H Zimmermann
name: Mancuso, Adrian
name: TRM Barends
name: RB Doak
name: CA Stan
name: I Schlichting
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Serial femtosecond crystallography (SFX) data were recorded at the European X-ray free-electron laser facility (EuXFEL) with protein microcrystals delivered via a microscopic liquid jet. An XFEL beam striking such a jet may launch supersonic shock waves up the jet, compromising the oncoming sample. To investigate this efficiently, we employed a novel XFEL pulse pattern to nominally expose the sample to between zero and four shock waves before being probed. Analyzing hit rate, indexing rate, and resolution for diffraction data recorded at MHz pulse rates, we found no evidence of damage. Notably, however, this conclusion could only be drawn after careful identification and assimilation of numerous interrelated experimental factors, which we describe in detail. Failure to do so would have led to an erroneous conclusion. Femtosecond photography of the sample-carrying jet revealed critically different jet behavior from that of all homogeneous liquid jets studied to date in this manner.
Development and Application of Image-Based High-Throughput Phenotyping Methodology for Salt Tolerance in Lentils
Creators: name: Dissanayake, Ruwani
name: Kahrood, Hossein V
name: Dimech, Adam M
name: Noy, Dianne M
name: Rosewarne, Garry M
name: Smith, Kevin F
name: Cogan, Noel
name: Kaur, Sukhjiwan
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3002
subject: Agriculture, land and farm management
classificationCode: 3004
subject: Crop and pasture production

description: No description supplied
Development and Application of Image-Based High-Throughput Phenotyping Methodology for Salt Tolerance in Lentils
Creators: name: Ruwani Dissanayake
name: Kahrood, Hossein V
name: Dimech, Adam M
name: Noy, Dianne M
name: Rosewarne, Garry M
name: Smith, Kevin F
name: Cogan, Noel
name: Sukhjiwan Kaur
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: No description supplied
sj-pdf-2-lup-10.1177_0961203320959716 - Supplemental material for A comparison and review of three sets of classification criteria for systemic lupus erythematosus for distinguishing systemic lupus erythematosus from pure mucocutaneous manifestations in the lupus disease spectrum
Creators: name: Jin, Hui
name: Huang, Tao
name: Wu, Ruifang
name: Zhao, Ming
name: Wu, Haijing
name: Long, Hai
name: Yin, Heng
name: Liao, Jieyue
name: Luo, Shuangyan
name: Liu, Yu
name: Zhang, Qing
name: Zhang, Peng
name: Tan, Yixin
name: Luo, Shuaihantian
name: Huang, Xin
name: Deng, Yaxiong
name: Liao, Wei
name: Duan, Liu
name: Chen, Jianbo
name: Zhou, Yin
name: Yin, Jinghua
name: Qiu, Hong
name: Yuan, Jin
name: Wang, Zijun
name: Li, Mengying
name: Wu, Xiaoqi
name: Chen, Lina
name: Cai, Liangmin
name: Huang, Cancan
name: Li, Qianwen
name: Tang, Bingsi
name: Yu, Bihui
name: Li, Xin
name: Gao, Xiaofei
name: Hu, Yixi
name: Ren, Xiaolei
name: Xue, Haofan
name: Wei, Zhangming
name: Chen, Jinwei
name: Li, Fen
name: Ling, Guanghui
name: Luo, Hui
name: Zhao, Hongjun
name: Yang, Sen
name: Cui, Yong
name: Lin, Youkun
name: Yao, Xu
name: Sun, Lingyun
name: Guo, Qing
name: Fang, Hong
name: Zeng, Kang
name: Deng, Danqi
name: Zhang, Jianzhong
name: Li, Yuzhen
name: Pu, Xiongming
name: Liao, Xiangping
name: Dang, Xiqiang
name: Huang, Danlin
name: Liang, Yumei
name: Sun, Qing
name: Xie, Hongju
name: Zeng, Li
name: Huang, Cibo
name: Diao, Qingchun
name: Tao, Juan
name: Yu, Jianbin
name: Li, Zhenlu
name: Xu, Hanshi
name: Li, Hui
name: Lai, Wei
name: Liu, Xiguang
name: Wu, Jingjing
name: Li, Tienan
name: Lei, Tiechi
name: Sun, Qiuning
name: Li, Yanjia
name: Zhang, Guoqiang
name: Lu, Qianjin
Publisher: name: SAGE Journals
Year: 2020
Subjects: Aged Health Care

description: Supplemental material, sj-pdf-2-lup-10.1177_0961203320959716 for A comparison and review of three sets of classification criteria for systemic lupus erythematosus for distinguishing systemic lupus erythematosus from pure mucocutaneous manifestations in the lupus disease spectrum by Hui Jin, Tao Huang, Ruifang Wu, Ming Zhao, Haijing Wu, Hai Long, Heng Yin, Jieyue Liao, Shuangyan Luo, Yu Liu, Qing Zhang, Peng Zhang, Yixin Tan, Shuaihantian Luo, Xin Huang, Yaxiong Deng, Wei Liao, Liu Duan, Jianbo Chen, Yin Zhou, Jinghua Yin, Hong Qiu, Jin Yuan, Zijun Wang, Mengying Li, Xiaoqi Wu, Lina Chen, Liangmin Cai, Cancan Huang, Qianwen Li, Bingsi Tang, Bihui Yu, Xin Li, Xiaofei Gao, Yixi Hu, Xiaolei Ren, Haofan Xue, Zhangming Wei, Jinwei Chen, Fen Li, Guanghui Ling, Hui Luo, Hongjun Zhao, Sen Yang, Yong Cui, Youkun Lin, Xu Yao, Lingyun Sun, Qing Guo, Hong Fang, Kang Zeng, Danqi Deng, Jianzhong Zhang, Yuzhen Li, Xiongming Pu, Xiangping Liao, Xiqiang Dang, Danlin Huang, Yumei Liang, Qing Sun, Hongju Xie, Li Zeng, Cibo Huang, Qingchun Diao, Juan Tao, Jianbin Yu, Zhenlu Li, Hanshi Xu, Hui Li, Wei Lai, Xiguang Liu, Jingjing Wu, Tienan Li, Tiechi Lei, Qiuning Sun, Yanjia Li, Guoqiang Zhang, Xin Huang and Qianjin Lu in Lupus
sj-pdf-4-tra-10.1177_1460408620968341 - Supplemental material for Chronic physical health conditions and associated factors among people with serious orthopaedic injuries: A systematic review
Creators: name: Asmare Yitayeh Gelaw
name: Gabbe, Belinda J
name: Braaf, Sandra C
name: McPhail, Steven
name: Ekegren, Christina L
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-4-tra-10.1177_1460408620968341 for Chronic physical health conditions and associated factors among people with serious orthopaedic injuries: A systematic review by Asmare Yitayeh Gelaw, Belinda J Gabbe, Sandra C Braaf, Steven McPhail and Christina L Ekegren in Trauma
Characterisation of an anticomplement polysaccharide BP-S1 from seeds of Brucea javanica
Creators: name: He, Xiao
name: Tan, Ting
name: Yang, Shilin
name: Feng, Yulin
name: Wen, Quan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Bioactivity-guided purification obtained polysaccharide BP-S1 from seeds of Brucea javanica. The results showed that BP-S1 was a homogenous polysaccharide with molecular weight of 45.7 kDa, mainly composed of arabinose and glucose in the ratio of 1.0:1.0 and the backbone of BP-S1 was deduced to be →3,4)-α-Glup-(1→ with branches of →2)-α-Arap-(1→and α-Arap-(1→, and the possible repetitive units were speculated according to result of methylation and 2D-NMR. Moreover, BP-S1 is a periodic rope-like structure. Functional analysis revealed that BP-S1 inhibited complement activation on the classic and alternative pathways with values of CH50 0.073 ± 0.012 mg/mL and AP50 0.097 ± 0.004 mg/mL, respectively. In mechanism study, using complement component depleted-sera methods indicated that BP-S1 selectively interacted with C3 and C4 components.
Effectiveness and cost-effectiveness of TeleStroke consultations to support the care of patients who had a stroke presenting to regional emergency departments in Western Australia: an economic evaluation case study protocol
Creators: name: C Tsou
name: S Robinson
name: Boyd, James
name: S Kamath
name: J Yeung
name: S Waters
name: K Gifford
name: A Jamieson
name: D Hendrie
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021 American Society of Civil Engineers (ASCE). All rights reserved. Introduction The Western Australia (WA) Acute TeleStroke Programme commenced incrementally across regional WA during 2016-2017. Since the introduction of the TeleStroke Programme, there has been monitoring of service outputs, including regional patient access to tertiary stroke specialist advice and reperfusion treatment; however, the impact of consultation with a stroke specialist via telehealth (videoconferencing or telephone) on the effectiveness and cost-effectiveness of stroke care and the drivers of cost-effectiveness has not been systematically evaluated. Methods and analysis The aim of the case study was to examine the impact of consultation with a stroke specialist via telehealth on the effectiveness and cost-effectiveness of stroke and transient ischaemic attack care using a mixed methods approach. A categorical decision tree model will be constructed in collaboration with clinicians and programme managers. A before and after comparison using state-wide administrative datasets will be used to run the base model. If sample size and statistical power permits, the cases and comparators will be matched by stroke type and presence of CT scan at the initial site of presentation, age category and presenting hospital. The drivers of cost-effectiveness will be explored through stakeholder interviews. Data from the qualitative analysis will be cross-referenced with trends emerging from the quantitative dataset and used to guide the factors to be involved in subgroup and sensitivity analysis. Ethics and dissemination Ethics approval for this case study has been granted from the Western Australian Country Health Service Human Research and Ethics Committee (RGS3076). Reciprocal approval has been granted from Curtin University Human Research Ethics Office (HRE2019-0740). Findings will be disseminated publicly through conference presentation and peer-review publications. Interim findings will be released as internal reports to inform the service development.
Two novel alkaloids from Portulaca oleracea L. and their anti-inflammatory bioactivities
Creators: name: Wang, Chengyu
name: Guo, Shengnan
name: Zhao, Yingdai
name: Wang, Jinhuan
name: Yang, Ying
name: Ying, Xixiang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Two novel alkaloids were identified as (E)-N-(4-3,4-dihydroxy-6-(hydroxymethyl)-5–3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxyphenyl)-3-(4-hydroxyphenyl)acrylamide (1), named Oleracrylimide D, (E)-N-(4-3,4-dihydroxy-6-(hydroxymethyl)-5-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (2), named Oleracrylimide E, isolated from Portulaca oleracea L. The structures were identified by spectroscopic methods, including 1D NMR, 2D NMR, and UHPLC-ESI-QTOF/MS methods, also, the anti-inflammatory bioactivities of the compounds were studied by ELISA method.
Effects of Lumbar Spine Abnormality and Serve Types on Lumbar Kinematics in Elite Adolescent Tennis Players
Creators: name: Connolly, Molly
name: Middleton, Kane
name: G Spence
name: O Cant
name: M Reid
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2021, The Author(s). Background: Low back pain (LBP) is pervasive among elite junior tennis players. Previous research has explored the relationship between serving mechanics and LBP, though the participants in these studies had already experienced LBP. Therefore, it is unclear whether their serving mechanics caused the LBP or are a result of having LBP. Thus, the purpose of this study was to compare the flat and kick serve kinematics of asymptomatic elite adolescent male and female tennis players with and without lumbar spine abnormalities. Twenty-four players (nine of which had confirmed lumbar spine abnormalities) carried out a series of flat and kick serves, while marker trajectories were recorded by a 3D motion capture system. Pelvis and lumbar spine kinematics (anterior/posterior tilt, lateral tilt, axial rotation and flexion/extension, lateral flexion and axial rotation respectively) were compared between players with and without lumbar spine abnormalities, genders, and serve types using a mixed-effects model. Exploratory data pertaining to the order and timing of key serve events was also collected. Results: Males had significantly greater posterior pelvis tilt than females during the drive phase of both flat (M, − 7.1 ± 5°; F, 4 ± 5.5°) and kick serves (M, − 8.6 ± 5.1°; F, 2.1 ± 5.8°). Independent of serve type, males also impacted the ball ~ 15 cm further into the court than females, while all players contacted flat serves significantly further forward (~ 17 cm). There were no effects for abnormality in the magnitude of pelvis and trunk kinematics. The order and timing of key serve events, however, did tend to differ between those with and without lumbar spine abnormalities. Players with abnormalities entered peak front knee flexion and initiated pelvis rotation earlier than players without abnormalities. Lastly, the timing of pelvis rotation was highly variable among females though not males. Conclusion: Pelvis and ball toss kinematics vary with gender and serve type but not necessarily abnormality in the elite adolescent serve. There is evidence to suggest that the order and timing of key serve events might help to identify those at risk of lumbar spine abnormalities; however, further research is needed to investigate the statistical significance of the timing of these events.
Incidence of HIV and HCV in people who inject drugs: A systematic and meta-analysis review protocol
Creators: name: A Sharhani
name: Z Jorjoran Shushtari
name: A Rahmani
name: B Armoon
name: M Noroozi
name: E Ahounbar
name: SE Karimi
name: Higgs, Peter
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Introduction HIV and hepatitis C virus (HCV) are major health concerns globally. This systematic review and meta-analysis protocol study aims to estimate the incidence of HIV and HCV among people who inject drugs (PWIDs) by reviewing studies that have applied mathematical modelling. The primary purpose of this systematic review is to identify and review mathematical modelling studies of HIV and HCV incidence in PWIDs. Methods and analysis cohort, cross-sectional and clinical trial studies conducted to estimate the incidence of HIV and HCV based on mathematical models or have evaluated the effectiveness of mathematical models will be considered for inclusion in the review. A comprehensive search applying a Cochrane approach will be used to identify relevant primary studies, published between January 2000 and July 2020, and indexed in PubMed, EMBASE, Opengrey, WOS, SCOPUS and Cochrane Library with no restriction on language. This protocol was prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Study selection and data extraction will be performed by two independent reviewers. Assessment of risk of bias will be implemented using forms of the Critical Appraisal Skills Programme. Publication bias will be assessed by funnel plots, Begg's and Egger's tests. A meta-analysis will be conducted to answer the first research question, 'What is the incidence of HIV and HCV when applying mathematical model in PWID?'. Clinical heterogeneity will be assessed by looking at the characteristics of participants, method of diagnosis and case definitions in the included primary studies. In addition, subgroup analyses will be conducted for population and secondary outcomes. Ethics and dissemination There are no ethical issues related to this study. The findings will be published in peer-reviewed scientific journals and presented at international and national conferences. PROSPERO registration number CRD42019126476.
Three new compounds from the seeds of Sinapis alba L
Creators: name: Kong, Degang
name: Li, Chuanhou
name: Ding, Liang
name: Tian, Zhenhua
name: Wang, Lu
name: Liu, Xue
name: Kong, Qinghe
name: Zhou, Honglei
name: Liao, Lin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Three undescribed compounds, 1-(4-hydroxyphenyl)-3-((4-hydroxyphenyl)thio) −2-propanone (I), 4′-hydroxybenzyl 4-(4′′- hydroxybenzyloxy) benzyl thioether (II) and 3-(4′-hydroxybenzyl)-6-hydroxy-quinazolinone (III) were isolated from the seeds of Sinapis alba L. The structures of all compounds were elucidated based on NMR and MS analysis, along with the comparison with published data. The potential targets of compounds I-III were identified by virtual screening. The potential inhibitory effects of these compounds on protein kinase C theta type were compared by molecular docking. The docking score of compound III was the highest.
Two new sesquiterpene glycosides from the stems of Dendrobium henanense and their anti-inflammatory activity
Creators: name: Wu, Si-Yu
name: Jie, Hui-Yang
name: Wu, De-Ling
name: Qin, Shi-Hui
name: Tang, Xu
name: Wang, Ren-Zhong
name: Xu, Feng-Qing
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Two new sesquiterpene glycosides, 8α,12,15β-trihydroxycopacamphan-15-O-β-D-glucopyranoside (1) and dendrobiumane C-11-O-β-D-glucopyranoside (2), along with three known terpenoids (3-5) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated based on NMR-spectroscopic and HR-MS analyses. All compounds could reduce the levels of NO, TNF-α and IL-1β in LPS-induced RAW264.7 cells with IC50 values ranging from 10.37 to 34.55 µΜ.
The Development of Empirically Derived Australian Low-Risk Gambling Limits
Creators: name: Dowling, Nicki A
name: Youssef, George J
name: Greenwood, Christopher
name: Merkouris, Stephanie S
name: Suomi, Aino
name: Room, Robin
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: This study derived a set of Australian low-risk gambling limits and explored the relative and absolute risk associated with exceeding these limits. Secondary analysis of population-representative Tasmanian and Australian Capital Territory (ACT) cross-sectional (11,597 respondents) and longitudinal studies (2027 respondents) was conducted. Balancing sensitivity and specificity, the limits were: gambling frequency of 20–30 times per year; gambling expenditure of AUD $380–$615 per year (USD $240–$388 per year); gambling expenditure comprising 0.83–1.68% of gross personal income; and two types of gambling activities per year. All limits, except number of activities, predicted subsequent harm, with limits related to gambling expenditure consistently the best-performing. Exceeding the limits generally conferred a higher degree of relative and absolute risk, with gamblers exceeding the limits being 3–20 times more likely to experience harm than those who do not, and having a 5–17% risk of experiencing harm. Only 7–12% of gamblers exceeding the limits actually experienced harm. Gambling consumption lower than the limits also conferred a considerable amount of harm. Using a relative risk method, this study derived similar limits from disparate Australian states and territories. These limits can serve as working guidelines for the consideration of researchers, clinicians, and policy makers, but need to be subject to further rigorous empirical investigation.
Additional file 1 of Educational training to improve opioid overdose response among health center staff: a quality improvement initiative
Creators: name: Stephenson, Audrey
name: Calvo-Friedman, Alessandra
name: Altshuler, Lisa
name: Zabar, Sondra
name: Hanley, Kathleen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Additional file 1. Pre- and post-test.
Comparisons of leisure-Time physical activity participation by adults with and without a disability: Results of an Australian cross-sectional national survey
Creators: name: L Hassett
name: Shields, Nora
name: J Cole
name: K Owen
name: C Sherrington
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Objectives The objective of this study was to describe and compare the amount and type of leisure-Time physical activity, and motivations and barriers to participation among adults with and without a disability. Methods Analysis of deidentified data from an Australian cross-sectional national telephone-based survey (October 2015 to June 2018) of sport and physical recreation participation over the previous 12 months, and barriers and motivations to participation. Descriptive statistics (incorporating weighted proportions), χ 2 tests and regression analyses were conducted to describe aspects of participation and compare those with and without self-reported disability. Results Of the 54 343 adults surveyed, 15% reported a disability. Adults with a disability were half as likely to meet physical activity guidelines through sport and/or physical recreation than adults without a disability (OR 0.53, 95% CI 0.51 to 0.57). A greater proportion of adults with a disability participated in physical recreation only (40% vs 31%; χ 2 =187; p<0.001), whereas a greater proportion of adults without a disability participated in sport only (20% vs 12%; χ 2 =188; p<0.001). Adults with a disability were more motivated than adults without a disability to try a new activity for physical health or fitness benefits (55% vs 46%; χ 2 =36; p<0.001). The most reported barrier to participation for adults with a disability not currently participating in sport and/or physical recreation was poor health or injury (62%), whereas for adults without a disability it was lack of time/too many other commitments (43%). Conclusion Adults with a disability are less physically active and report different physical activity profiles and barriers to being active than adults without a disability. Urgent action is required to address this discrepancy.
JOM_SOM_R4 – Supplemental material for The Consequences of Participating in the Sharing Economy: A Transparency-Based Sharing Framework
Creators: name: Köbis, Nils C.
name: Soraperra, Ivan
name: Shalvi, Shaul
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, JOM_SOM_R4 for The Consequences of Participating in the Sharing Economy: A Transparency-Based Sharing Framework by Nils C. Köbis, Ivan Soraperra and Shaul Shalvi in Journal of Management