cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Examining the class B-to-A shift of the 7.7 $μ$m PAH band with the NASA Ames PAH IR Spectroscopic Database
Creators: name: Shannon, M. J.
name: Boersma, C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present insights into the behavior of the astronomical 7.7 $μ$m polycyclic aromatic hydrocarbon (PAH) emission complex as gleaned from analyzing synthesized spectra, utilizing the data and tools from the NASA Ames PAH IR Spectroscopic Database. We specifically study the influence of PAH size, charge, aliphatic content and nitrogen substitution on the profile and peak position of the 7.7 $μ$m feature ($λ$7.7). The 7.7 $μ$m band is known to vary significantly from object-to-object in astronomical observations, but the origin of these variations remains highly speculative. Our results indicate that PAH size can accommodate the largest shift in $λ$7.7 (~0.4 $μ$m), where relatively small PAHs are consistent with class A spectra (fewer than 60 carbon atoms) while large PAHs are consistent with red/very red class B spectra. Aliphatic PAHs, of which our sample only contains a few, can produce redshifts typically around 0.15 $μ$m; changes in ionization fraction, depending on the species, produce shifts up to 0.1 $μ$m; and nitrogen substitution has no effect on $λ$7.7. Within the limits of our study, the class B-to-A transition is best explained with a changing PAH size distribution, with a relatively minor role assigned to aliphatic content and varying charge states. The resulting astronomical picture is that the photochemical evolution of PAHs moving from shielded class C/B environments into exposed ISM-like class A environments may be intrinsically different from the reverse class A-to-B transition of interstellar PAHs being incorporated into newly-forming star systems.
description: 21 pages, 12 figures; accepted for publication in The Astrophysical Journal
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
Creators: name: Singla, Shruti
name: Iwamoto-Stohl, Lisa K.
name: Zhu, Meng
name: Zernicka-Goetz, Magdalena
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/136
/631/136/2086
/631/136/1455
/14
/14/19
/64
/64/60
/38
/38/89
/38/77
article

description: Funder: Open Philanthropy grants to M.Z.G.
description: Abstract: The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dealing with aneuploidy is fundamental to normal development, the mechanisms responsible for eliminating aneuploid cells are unclear. Here, using a mouse model of chromosome mosaicism, we show that aneuploid cells are preferentially eliminated from the embryonic lineage in a p53-dependent process involving both autophagy and apoptosis before, during and after implantation. Moreover, we show that diploid cells in mosaic embryos undertake compensatory proliferation during the implantation stages to confer embryonic viability. Together, our results indicate a close link between aneuploidy, autophagy, and apoptosis to refine the embryonic cell population and ensure only chromosomally fit cells proceed through development of the fetus.
Romantic Fragmentation and Victorian Censorship: Rethinking Nineteenth-Century Authorship
Creators: name: Ioannidou, Elisavet
Publisher: name: Gramma: Journal of Theory and Criticism
Year: 2013

description: This essay examines how and to what extent the growth and professionalization of the publishing industry during the nineteenth century created in­consistencies between the text that was originally produced by an author and the text that eventually appeared as a published book. Drawing on con­temporary literary theory's conflicting views on the status and significance of the author, it attempts a reconciliatory approach that views the author and the literary text as social entities that interact with the reader. On this ground, the essay discusses examples drawn from the publishing industry's interference with Romantic fragments on the one hand, and Victorian cen­sored texts on the other in order to highlight the ways in which the pub­lishing industry has shaped the nineteenth-century author and his/ her work; subsequently, this analysis helps explore the implications that the mediation of the publishing industry has for the consumption of nineteenth-century literature nowadays.
description: Gramma: Journal of Theory and Criticism, Vol 21 (2013): The History and Future of the 19th-Century Book
Kinematics of Type II Cepheids of the Galactic Halo
Creators: name: Wallerstein, George
name: Farrell, Elizabeth M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In a step toward understanding the origin of the Galactic Halo, we have reexamined Type II Cepheids (T2C) in the field with new input from the second data release (DR2) of Gaia. For 45 T2C with periods from 1 to 20 days, parallaxes, proper motions, and [Fe/H] values are available for 25 stars. Only 5 show [Fe/H] < -1.5, while the remaining stars show thick disk kinematics and [Fe/H] > -0.90. We have compared the T2C stars of the field with their cousins in the globular clusters of the Halo and found that the globular clusters with T2C stars show metallicities and kinematics of a pure Halo population. The globulars may have formed during the overall collapse of the Galaxy while the individual thick disk T2C stars may have been captured from small systems that self-enriched prior to capture. The relationship of these two populations to the micro-galaxies currently recognized as surrounding the Galaxy is unclear.
description: 7 pages, 3 figures, 4 tables
Critical phenomena and a new class of self-similar spherically symmetric perfect-fluid solutions
Creators: name: Carr, B. J.
name: Coley, A. A.
name: Goliath, M.
name: Nilsson, U. S.
name: Uggla, C.
Publisher: name: arXiv
Year: 1999
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider the self-similar solutions associated with the critical behavior observed in the gravitational collapse of spherically symmetric perfect fluids with equation of state $p=αμ$. We identify for the first time the global nature of these solutions and show that it is sensitive to the value of $α$. In particular, for $α>0.28$, we show that the critical solution is associated with a new class of asymptotically Minkowski self-similar spacetimes. We discuss some of the implications of this for critical phenomena.
description: 5 pages RevTeX, 5 eps figures
Single-Cell Biochemical Multiplexing by Multidimensional Phasor Demixing and Spectral Fluorescence Lifetime Imaging Microscopy
Creators: name: Haas, Kalina T.
name: Fries, Maximilian W.
name: Venkitaraman, Ashok R.
name: Esposito, Alessandro
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Physics
sFLIM
FRET biosensors
TCSPC
spectral demixing
biochemical multiplexing

description: Revealing mechanisms underpinning cell function requires understanding the relationship between different biochemical reactions in living cells. However, our capabilities to monitor more than two biochemical reactions in living cells are limited. Therefore, the development of methods for real-time biochemical multiplexing is of fundamental importance. Here, we show that data acquired with multicolor (mcFLIM) or spectrally resolved (sFLIM) fluorescence lifetime imaging can be conveniently described with multidimensional phasor transforms. We demonstrate a computational framework capable of demixing three Forster resonance energy transfer (FRET) probes and quantifying multiplexed biochemical activities in single living cells. We provide a comparison between mcFLIM and sFLIM suggesting that sFLIM might be advantageous for the future development of heavily multiplexed assays. However, mcFLIM—more readily available with commercial systems—can be applied for the concomitant monitoring of three enzymes in living cells without significant losses.
Books in Pieces: Granger, History, and the Collection
Creators: name: Macovski, Michael
Publisher: name: Gramma: Journal of Theory and Criticism
Year: 2013

description: This article analyzes the influence of James Granger's Biographical His­tory of England (1769), a volume that spearheaded a remarkable praxis of collecting, interleaving, and rebinding during the eighteenth and nineteenth centuries. This praxis reflects not only radical changes in concepts of col­lecting during this period, but also three central dimensions of book his­tory. These include the era's passion for artefactual collections; its propen­sity for annotative forms, such as marginalia and prefaces; and its burgeon­ing publication of compilatory, systematized texts—such as catalogues, al­manacs, encyclopedias, and other compendium forms. The article goes on to suggest that grangerized texts extend beyond simple, stochastic gather­ings to reveal key precepts of historiographic continuity, serialized succes­sion, ekphrastic reproduction, and synoptic collectivity.
description: Gramma: Journal of Theory and Criticism, Vol 21 (2013): The History and Future of the 19th-Century Book
Observations of Spin-Down in Post-Mast-Transfer Stars and the Possibility for Blue Straggler Gyrochronology
Creators: name: Leiner, Emily
name: Mathieu, Robert
name: Gosnell, Natalie
name: Sills, Alison
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Blue stragglers and other mass transfer/collision products are likely born with rapid rotation rates due to angular momentum transfer during mass-transfer, merger or collisional formation. However, less is known about the angular momentum evolution of these stars as they age. Here we compare rotation rates and post-formation ages of mass-transfer products to models of angular momentum evolution for normal main-sequence stars and collisionally formed blue stragglers. In our sample, we include both F- and G-type blue stragglers in the cluster NGC 188 and post-mass-transfer GK main-sequence stars in the field, all binaries with WD companions. We compare ages derived from WD cooling models to photometric rotation periods and/or spectral vsini measurements. We demonstrate that these systems have rapid rotation rates soon after formation. They then spin down as they age much as standard solar-type main-sequence stars do. We discuss the physical implications of this result, which suggests that the spin-down of post-mass transfer stars can be described by standard magnetic-braking prescriptions. This opens up the possibility of using gyrochronology as a method to determine the time since formation of blue straggler stars and other post-mass-transfer binaries.
description: 7 Pages, 1 Figure, 1 Table, accepted to ApJ Letters
“Scarers in Print”: Media Literacy and Media Practice from Our Mutual Friend to Friend Me On Facebook
Creators: name: Mussell, James
Publisher: name: Gramma: Journal of Theory and Criticism
Year: 2013

description: In Charles Dickens's Our Mutual Friend, Noddy Boffin is surprised at what he finds in books, remarking that he didn't think "there was half so many Scarers in Print." This paper explores whether or not there are Scar­ers in Print. For Boffin, reading is unsettling as it turns books into con­tainers, from which content can be liberated by those in the know. How­ever, content is not contained within the book, but produced through an encounter with it. When readers read, the body of the book disappears in exchange for apparently resurrected content, packaged up and stored by the author. But what happens to the body of the book when it disappears? And under what conditions does it return? Taking in examples from nine­teenth-century literature to Facebook, this paper explores this gothic econ­omy of repression and return. Reading and writing are embodied practices: only a literacy that encompasses materiality—what readers do, rather than what they read—can account for the Scarers in Print.
description: Gramma: Journal of Theory and Criticism, Vol 21 (2013): The History and Future of the 19th-Century Book
McKitterick, David, ed. The Cambridge History of the Book in Britain. Volume VI: 1830-1914. Cambridge: Cambridge University Press, 2009 (pp 826). ISBN 9780521866248.
Creators: name: Bautz, Annika
Publisher: name: Gramma: Journal of Theory and Criticism
Year: 2013

description: Gramma: Journal of Theory and Criticism, Vol 21 (2013): The History and Future of the 19th-Century Book
Generic occurrence of rings in rotating systems
Creators: name: Benet, L.
name: Seligman, T. H.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: In rotating scattering systems, the generic saddle-center scenario leads to stable islands in phase space. Non-interacting particles whose initial conditions are defined in such islands will be trapped and form rotating rings. This result is generic and also holds for systems quite different from planetary rings.
description: 10 pages, 5 ps figures; uses elsart.sty and epsfig.sty Accepted in Phys. Lett. A
Aggregation dynamics of active cells on non-adhesive substrate
Creators: name: Mukhopadhyay, Debangana
name: De, Rumi
Publisher: name: arXiv
Year: 2019
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Cellular Automata and Lattice Gases (nlin.CG)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Cellular self-assembly and organization are fundamental steps for the development of biological tissues. In this paper, within the framework of a cellular automata model, we address how an ordered tissue pattern spontaneously emerges from a randomly migrating single cell population without the influence of any external cues. This model is based on the active motility of cells and their ability to reorganize due to cell-cell cohesivity as observed in experiments. Our model successfully emulates the formation of nascent clusters and also predicts the temporal evolution of aggregates that leads to the compact tissue structures. Moreover, the simulations also capture several dynamical properties of growing aggregates, such as, the rate of cell aggregation and non-monotonic growth of the aggregate area which show a good agreement with the existing experimental observations. We further investigate the time evolution of the cohesive strength, and the compactness of aggregates, and also study the ruggedness of the growing structures by evaluating the fractal dimension to get insights into the complexity of tumorous tissue growth which were hitherto unexplored.
Piper, Andrew. Dreaming in Books: The Making of the Bibliographic Imagination in the Romantic Age. Chicago and London: The University of Chicago Press, 2009 (pp xv+303). ISBN 9780226669724.
Creators: name: McCue, Maureen
Publisher: name: Gramma: Journal of Theory and Criticism
Year: 2013

description: Gramma: Journal of Theory and Criticism, Vol 21 (2013): The History and Future of the 19th-Century Book
Topological free volume and quasi-glassy dynamics in melt of ring polymers
Creators: name: Sakaue, Takahiro
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Motivated by recent observations that non-concatenated ring polymers in their dense solution exhibit a glass-like dynamics, we propose a free volume description of the motion of such rings based on the notion of topological volume. We first construct a phenomenological free energy which enables one to qnaitify the degree of topological crowding measured by the coordination number. Then we pinpoint a key role of the cooperative dynamics of neighboring rings, which is responsible for an anomalous dependence of the global structural relaxation (diffusion) time on ring length. Predictions on molecular weight dependence of both static (ring size, coordination number) and dynamic (relaxation time, diffusion coefficient) quantities are in very good agreement with reported numerical simulations. Throughout the discussion, the entanglement length $N_e$ is assumed to be a unique characteristic length for the topological constraint, hence, all the physical quantities are universally described in terms of the rescaled chain length $N/N_e$. Finally, we discuss how the dense solution of rings is analogous yet different from ordinary glassy systems.
description: 10 pages, 5 figures
Classification of spherical fusion categories of Frobenius-Schur exponent 2
Creators: name: Wan, Zheyan
name: Wang, Yilong
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: In this paper, we propose a new approach towards the classification of spherical fusion categories by their Frobenius-Schur exponents. We classify spherical fusion categories of Frobenius-Schur exponent 2 up to monoidal equivalence. We also classify modular categories of Frobenius-Schur exponent 2 up to braided monoidal equivalence. It turns out that the Gauss sum is a complete invariant for modular categories of Frobenius-Schur exponent 2. This result can be viewed as a categorical analog of Arf's theorem on the classification of non-degenerate quadratic forms over fields of characteristic 2.
description: 11 pages. Comments are welcome
Additional file 4: of Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study
Creators: name: Solini, Anna
name: Penno, Giuseppe
name: Orsi, Emanuela
name: Bonora, Enzo
name: Fondelli, Cecilia
name: Trevisan, Roberto
name: Vedovato, Monica
name: Cavalot, Franco
name: Lamacchia, Olga
name: Baroni, Marco
name: Nicolucci, Antonio
name: Pugliese, Giuseppe
Publisher: name: figshare
Year: 2019
Subjects: subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Figure S2. Cox proportional hazards regression, unadjusted (A) and adjusted for age and gender (B) plus CVD risk factors (C) plus complications/comorbidities (D), according to BP status (based on the 140/90â mmHg BP targets). HRs (95% CI) for mortality are shown for each group. NT = normotension; UTHT = untreated hypertension; CHT = controlled hypertension; UCHT = uncontrolled hypertension; RHT = resistant hypertension. (DOC 809 kb)
Additional file 1 of Exploring the novel duo of Reticulocalbin, and Sideroflexin as future biomarker candidates for Exacerbated Chronic Obstructive Pulmonary Disease
Creators: name: Das, Sonu
name: Adiody, Supriya
name: Varghese, Jinsu
name: Vanditha, M
name: Maria, Evelyn
name: John, Mathew
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Supplementary Material 1
Statistical properties of the energy release in emerging and evolving active region
Creators: name: Vlahos, L.
name: Fragos, T.
name: Isliker, H.
name: Georgoulis, M.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The formation and evolution of active regions is an inherently complex phenomenon. Magnetic fields generated at the base of the convection zone follow a chaotic evolution before reaching the solar surface. In this article, we use a 2-D probabilistic Cellular Automaton (CA) to model the statistical properties of the magnetic patterns formed on the solar surface and to estimate the magnetic energy released in the interaction of opposite polarities. We assume that newly emerged magnetic flux tubes stimulate the emergence of new magnetic flux in their neighborhood. The flux-tubes move randomly on the surface of the sun, and they cancel and release their magnetic energy when they collide with magnetic flux of opposite polarity, or diffuse into the ``empty'' photosphere. We assume that cancellation of magnetic flux in collisions causes "flares" and determine the released energy as the difference in the square of the magnetic field flux. The statistics of the simulated "flares" follow a power-law distribution in energy, with power-law index a=2.2 +/- 0.1. The size distribution function of the simulated active regions exhibits a power law behavior with index k = 1.93 +/- 0.08, and the fractal dimension of the magnetized areas on the simulated solar surface is close to D = 1.42 +/- 0.12. Both quantities, D and k, are inside the range of the observed values.
description: in press at Astrophysical Journal Letters (2002) 4 figures
Additional file 2: of Postponed or immediate drainage of infected necrotizing pancreatitis (POINTER trial): study protocol for a randomized controlled trial
Creators: name: Grinsven, Janneke
name: Dijk, Sven
name: Dijkgraaf, Marcel
name: Boermeester, Marja
name: Bollen, Thomas
name: Bruno, Marco
name: Brunschot, Sandra
name: Dejong, Cornelis
name: Eijck, Casper
name: Lienden, Krijn
name: Boerma, Djamila
name: Duijvendijk, Peter
name: Hadithi, Muhammed
name: Haveman, Jan
name: RenĂŠ Hulst
name: Jansen, Jeroen
name: Lips, Daan
name: Manusama, Eric
name: I. Molenaar
name: Peet, Donald
name: Poen, Alexander
name: Quispel, Rutger
name: Schaapherder, Alexander
name: Schoon, Erik
name: Schwartz, Matthijs
name: Seerden, Tom
name: B. Spanier
name: Straathof, Jan
name: Venneman, Niels
name: Vrie, Wim
name: Witteman, Ben
name: Goor, Harry
name: Fockens, Paul
name: Santvoort, Hjalmar
name: Besselink, Marc
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Inclusion and exclusion criteria. (DOCX 14 kb)
Risk factors for the development of neonatal sepsis in a neonatal intensive care unit of a tertiary care hospital of Nepal
Creators: name: Manandhar, Sulochana
name: Amatya, Puja
name: Ansari, Imran
name: Joshi, Niva
name: Maharjan, Nhukesh
name: Dongol, Sabina
name: Basnyat, Buddha
name: Dixit, Sameer M.
name: Baker, Stephen
name: Karkey, Abhilasha
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research
Neonatal sepsis
NICU
Nepal
Risk factors
MDR
ESBL
Etiology
Epidemiology

description: Abstract: Background: Sepsis is an overwhelming and life-threatening response to bacteria in bloodstream and a major cause of neonatal morbidity and mortality. Understanding the etiology and potential risk factors for neonatal sepsis is urgently required, particularly in low-income countries where burden of infection is high and its epidemiology is poorly understood. Methods: A prospective observational cohort study was conducted between April 2016 and October 2017 in a level three NICU at a tertiary care hospital in Nepal to determine the bacterial etiology and potential risk factors for neonatal sepsis. Results: Among 142 NICU admitted neonates, 15% (21/142) and 32% (46/142) developed blood culture-positive and -negative neonatal sepsis respectively. Klebsiella pneumoniae (34%, 15/44) and Enterobacter spp. (25%, 11/44) were the most common isolates. The antimicrobial resistance of isolates to ampicillin (100%, 43/43), cefotaxime (74%, 31/42) and ampicillin-sulbactam (55%, 21/38) were the highest. BlaTEM (53%, 18/34) and blaKPC (46%, 13/28) were the commonest ESBL and carbapenemase genes respectively. In univariate logistic regression, the odds of sepsis increased with each additional day of use of invasive procedures such as mechanical ventilation (OR 1.086, 95% CI 1.008–1.170), umbilical artery catheter (OR 1.375, 95% CI 1.049–1.803), intravenous cannula (OR 1.140, 95% CI 1.062–1.225); blood transfusion events (OR 3.084, 95% CI 1.407–6.760); NICU stay (OR 1.109, 95% CI 1.040–1.182) and failure to breast feed (OR 1.130, 95% CI 1.060–1.205). Sepsis odds also increased with leukopenia (OR 1.790, 95% CI 1.04–3.082), increase in C-reactive protein (OR 1.028, 95% CI 1.016–1.040) and decrease in platelets count (OR 0.992, 95% CI 0.989–0.994). In multivariate analysis, increase in IV cannula insertion days (OR 1.147, 95% CI 1.039–1.267) and CRP level (OR 1.028, 95% CI 1.008–1.049) increased the odds of sepsis. Conclusions: Our study indicated various nosocomial risk factors and underscored the need to improve local infection control measures so as to reduce the existing burden of sepsis. We have highlighted certain sepsis associated laboratory parameters along with identification of antimicrobial resistance genes, which can guide for early and better therapeutic management of sepsis. These findings could be extrapolated to other low-income settings within the region.
title: Das Längsschnittcurriculum Kommunikation an der Medizinischen Fakultät Leipzig – Ergebnisse der ersten Kohorte
Creators: name: Zimmermann, Anja
name: Baerwald, Christoph
name: Fuchs, Michael
name: Götze, Heide
name: Girbardt, Christian
name: Hempel, Gunther
name: von Klitzing, Kai
name: Rotzoll, Daisy
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: An der Medizinischen Fakultät der Universität Leipzig wird seit dem Wintersemester 2016/17 die Vermittlung kommunikativer Kompetenzen in das bestehende Curriculum integriert und mit klinisch-praktischen Inhalten verknüpft. Neben der Arzt-Patient-Kommunikation werden Teamkommunikation[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)
Initial Conditions in String Cosmology
Creators: name: Clancy, Dominic
name: Lidsey, James E.
name: Tavakol, Reza
Publisher: name: arXiv
Year: 1998
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We take a critical look at a recent conjecture concerning the past attractor in the pre-big-bang scenario. We argue that the Milne universe is unlikely to be a general past attractor for such models and support this with a number of examples.
description: 10 pages standard Latex format, no figures. Submitted to Phys. Rev. D
title: Kommunikative Kompetenzen: Welche gesprächsanalytischen Fertigkeiten weisen Studierende im ersten Semester Humanmedizin auf?
Creators: name: Bachmann, Cadja
name: Romeike, Bernd F. M.
name: Simmenroth, Anne
name: Kumbier, Ekkehardt
name: Lüpke, Johanna
name: Schötter, Susanne
name: Hake, Karsten
name: Siems, Ronald
name: Matthes, Erzsebet
name: Boy, Diana
name: Rebentisch, Franziska
name: Altiner, Attila
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: An der medizinischen Fakultät Rostock wurde im WS 2018/19 erstmalig ein longitudinales, interdisziplinäres Curriculum „Kommunikation“ implementiert und pilotiert. Studierende des ersten Semesters wurden zufällig in das neue Curriculum eingeteilt. Die Lehrveranstaltungen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)
Slowly Driven Sandpile Formation with Granular Mixtures
Creators: name: Head, D. A.
name: Rodgers, G. J.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We introduce a one-dimensional sandpile model with $N$ different particle types and an infinitesimal driving rate. The parameters for the model are the N^2 critical slopes for one type of particle on top of another. The model is trivial when N=1, but for N=2 we observe four broad classes of sandpile structure in different regions of the parameter space. We describe and explain the behaviour of each of these classes, giving quantitative analysis wherever possible. The behaviour of sandpiles with N>2 essentially consists of combinations of these four classes. We investigate the model's robustness and highlight the key areas that any experiment designed to reproduce these results should focus on.
description: 6 pages, RevTEX, 7 postscript figures and psfig.sty included
title: Der Einfluss extra- und intra-curricularer Vorerfahrungen auf den simulationsbasierten Gesprächsführungsunterricht
Creators: name: Koller, Desiree
name: Bäwert, Andjela
name: Wagner-Menghin, Michaela
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Mehrere Studien zeigen auf, dass eine bessere Arzt/Ärztin-Patient/inn/en-Kommunikation den Prozess der Gesundheitsförderung bis zur Erstellung einer Diagnose und Therapie verbessert und die Qualität der Gesundheitsversorgung erhöht [ref:1]. An[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)
The Coherence of Primordial Fluctuations Produced During Inflation
Creators: name: Kiefer, Claus
name: Lesgourgues, Julien
name: Polarski, David
name: Starobinsky, Alexei A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The behaviour of quantum metric perturbations produced during inflation is considered at the stage after the second Hubble radius crossing. It is shown that the classical correlation between amplitude and momentum of a perturbation mode, previously shown to emerge in the course of an effective quantum-to-classical transition, is maintained for a sufficiently long time, and we present the explicit form in which it takes place using the Wigner function. We further show with a simple diffraction experiment that quantum interference, non-expressible in terms of a classical stochastic description of the perturbations, is essentially suppressed. Rescattering of the perturbations leads to a comparatively slow decay of this correlation and to a complete stochastization of the system.
description: LaTeX (7 pages)
title: Der Einfluss von Simulationspatienten auf den Lernerfolg bei kommunikationsbasierenden Prüfungen
Creators: name: Koch, Yannic
name: Sterz, Jasmina
name: Stefanescu, Maria-Christina
name: Germanyuk, Aleksandra
name: Rüsseler, Miriam
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Ärztliche Kommunikation ist für die Berufsausübung essentiell. Die Vermittlung kommunikativer Fertigkeiten ist in den Curricula der deutschen Universitäten fest verankert. Dabei kann der Einsatz von Simulationspatienten sinnvoll sein, um den Studenten den realistischen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)
A Toolbox For Property Checking From Simulation Using Incremental SAT (Extended Abstract)
Creators: name: Sumners, Rob
Publisher: name: arXiv
Year: 2018
Subjects: subject: Software Engineering (cs.SE)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We present a tool that primarily supports the ability to check bounded properties starting from a sequence of states in a run. The target design is compiled into an AIGNET which is then selectively and iteratively translated into an incremental SAT instance in which clauses are added for new terms and simplified by the assignment of existing literals. Additional applications of the tool can be derived by the user providing alternative attachments of constrained functions which guide the iterations and SAT checks performed. Some Verilog RTL examples are included for reference.
description: In Proceedings ACL2 2018, arXiv:1810.03762
Reference Genes for Expression Studies in Human CD8 + Naïve and Effector Memory T Cells under Resting and Activating Conditions
Creators: name: Geigges, Marco
name: Gubser, Patrick M.
name: Unterstab, Gunhild
name: Lecoultre, Yannic
name: Paro, Renato
name: Hess, Christoph
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/1647/2017/2003
/631/208/199
/631/250/1619/554/1834
/38/77
/38/90
/13
/38
article

description: Abstract: Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is widely used for mRNA quantification. To accurately measure changing gene transcript levels under different experimental conditions, the use of appropriate reference gene transcripts is instrumental. In T cell immunology, suitable reference genes have been reported for bulk CD4+ and CD8+ T cells. However, many CD4+ and CD8+ T cell subsets have been described in the past. Although they respond differently to given activation stimuli, proper validation of suitable reference genes in these subsets is lacking. In this study, we evaluated twelve commonly used reference gene products in human naïve (NV) and effector memory (EM) CD8+ T cells under non-activated and activated (2 h, 10 h and 20 h) conditions. We used five different statistical approaches for data analysis. Our results show that a number of widely used reference transcripts become differentially expressed under activating conditions. Using them as references markedly alters results as exemplified with IFNG mRNA expression. The only candidate reference gene products that remained stable during the activation process were 18S rRNA and SDHA mRNA, encouraging their usage as reference gene products for RT-qPCR experiments, when quantifying mRNA levels in human NV and EM CD8+ T cells.
Brain training using cognitive apps can improve cognitive performance and processing speed in older adults
Creators: name: Bonnechère, Bruno
name: Klass, Malgorzata
name: Langley, Christelle
name: Sahakian, Barbara Jacquelyn
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/692/700/1518
/692/617/375/132
article

description: Funder: Fondation Philippe Wiener - Maurice Anspach; doi: http://dx.doi.org/10.13039/501100003138
description: Funder: Wallit Foundation
description: Funder: Eton College
description: Funder: NIHR MedTech and in vitro diagnostic Co-operative (MIC)
description: Funder: NIHR Cambridge Biomedical Research Centre (BRC) Mental Health and Neurodegeneration Themes
description: Abstract: Managing age-related decrease of cognitive function is an important public health challenge, especially in the context of the global aging of the population. Over the last years several Cognitive Mobile Games (CMG) have been developed to train and challenge the brain. However, currently the level of evidence supporting the benefits of using CMG in real-life use is limited in older adults, especially at a late age. In this study we analyzed game scores and the processing speed obtained over the course of 100 sessions in 12,000 subjects aged 60 to over 80 years. Users who trained with the games improved regardless of age in terms of scores and processing speed throughout the 100 sessions, suggesting that old and very old adults can improve their cognitive performance using CMG in real-life use.
title: Diagnosekompetenzmessung mit standardisierten Patienten und interaktiven Videosimulationen: Ergebnisse aus einer Studie zum Anamnesegespräch
Creators: name: Fink, Maximilian Christian
name: Reitmeier, Victoria
name: Siebeck, Matthias
name: Fischer, Frank
name: Fischer, Martin R.
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Diagnosekompetenzmessung von Medizinstudierenden mit standardisierten Patienten ist im Medizinstudium fest etabliert aber aufwendig. Die Diagnosekompetenzmessung mithilfe von interaktiven Videosimulationen bietet sich als hochverfügbare Alternative oder Ergänzung an und gewinnt[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)
Additional file 3: of Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study
Creators: name: Solini, Anna
name: Penno, Giuseppe
name: Orsi, Emanuela
name: Bonora, Enzo
name: Fondelli, Cecilia
name: Trevisan, Roberto
name: Vedovato, Monica
name: Cavalot, Franco
name: Lamacchia, Olga
name: Baroni, Marco
name: Nicolucci, Antonio
name: Pugliese, Giuseppe
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology

description: Table S2. Baseline clinical features in the RIACE participants with valid information on vital status and resistant hypertension on-target with >â 4 drugs or not on-target with >â 3 drugs according to the 140/90â mmHg BP targets. (DOCX 16 kb)
Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films
Creators: name: Kamada, Ayaka
name: Rodriguez-Garcia, Marc
name: Ruggeri, Francesco Simone
name: Shen, Yi
name: Levin, Aviad
name: Knowles, Tuomas P. J.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/639/638/298/54/1754
/639/301/923/966
/639/925/350/2251
/639/925/350/2093
/128
/147
/142/126
article

description: Funder: University of Cambridge | Darwin College, University of Cambridge (Darwin); doi: https://doi.org/10.13039/501100000595
description: Funder: Federation of European Biochemical Societies (FEBS); doi: https://doi.org/10.13039/100012623
description: Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 337969
description: Funder: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC); doi: https://doi.org/10.13039/501100000268
description: Abstract: The abundance of plant-derived proteins, as well as their biodegradability and low environmental impact make them attractive polymeric feedstocks for next-generation functional materials to replace current petroleum-based systems. However, efforts to generate functional materials from plant-based proteins in a scalable manner have been hampered by the lack of efficient methods to induce and control their micro and nanoscale structure, key requirements for achieving advantageous material properties and tailoring their functionality. Here, we demonstrate a scalable approach for generating mechanically robust plant-based films on a metre-scale through controlled nanometre-scale self-assembly of water-insoluble plant proteins. The films produced using this method exhibit high optical transmittance, as well as robust mechanical properties comparable to engineering plastics. Furthermore, we demonstrate the ability to impart nano- and microscale patterning into such films through templating, leading to the formation of hydrophobic surfaces as well as structural colour by controlling the size of the patterned features.
title: When and how do medical students achieve their concept of the ideal doctor!
Creators: name: Szalai, Cynthia
name: Herbstreit, Stephanie
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Germany is presently experiencing a movement towards competence-based medical training. A significant component of this training is self-reflection and student autonomy. To achieve their objective students must have a concept of what skills they think are relevant to their training, i.e.[for full text, please go to the a.m. URL]
description: Gemeinsame Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA), des Arbeitskreises zur Weiterentwicklung der Lehre in der Zahnmedizin (AKWLZ) und der Chirurgischen Arbeitsgemeinschaft Lehre (CAL)
Comment on entropy bounds and the generalized second law
Creators: name: Pelath, M. A.
name: Wald, Robert M.
Publisher: name: arXiv
Year: 1999
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In a gedanken experiment in which a box initially containing energy $E$ and entropy $S$ is lowered toward a black hole and then dropped in, it was shown by Unruh and Wald that the generalized second law of black hole thermodynamics holds, without the need to assume any bounds on $S$ other than the bound that arises from the fact that entropy at a given energy and volume is bounded by that of unconstrained thermal matter. The original analysis by Unruh and Wald made the approximation that the box was ``thin'', but they later generalized their analysis to thick boxes (in the context of a slightly different process). Nevertheless, Bekenstein has argued that, for a certain class of thick boxes, the buoyancy force of the ``thermal atmosphere'' of the black hole is negligible, and that his previously postulated bound on $S/E$ is necessary for the validity of the generalized second law. In arguing for these conclusions, Bekenstein made some assumptions about the nature of unconstrained thermal matter and the location of the ``floating point'' of the box. We show here that under these assumptions, Bekenstein's bound on $S/E$ follows automatically from the fact that $S$ is bounded by the entropy of unconstrained thermal matter. Thus, a box of matter which violates Bekenstein's bound would violate the assumptions made in his analysis, rather than violate the generalized second law. Indeed, we prove here that no universal entropy bound need be hypothesized in order to ensure the validity of the generalized second law in this process.
description: 12 pages, revtex
La transizione interna ed esterna della Cina
Creators: name: Marazzi, Marco
Publisher: name: OrizzonteCina
Year: 2024

description: Abstract


This paper examines the transformation of the Chinese economy and its impact on China's global interactions, as well as the reciprocal effects. China is now taking a more proactive role on the world stage, exemplified by initiatives like the Belt and Road Initiative and its participation in the RCEP. Additionally, China is upgrading its production capabilities, shifting from low-value-added to more sophisticated products, positioning itself as a leader in industries such as ICT. This evolving role of China is perceived as a threat, especially by the United States. However, complete decoupling from the Chinese economy proves exceedingly challenging due to the interconnectedness of global supply chains. Many countries still view China as a significant opportunity rather than solely a threat.
description: OrizzonteCina, Anteprime
Turbulent power spectrum in warm and cold neutral medium using the Galactic HI 21 cm emission
Creators: name: Choudhuri, Samir
name: Roy, Nirupam
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Small-scale fluctuations of different tracers of the interstellar the medium can be used to study the nature of turbulence in astrophysical scales. Of these, the `continuum' emission traces the fluctuations integrated along the line of sight whereas, the spectral line tracers give the information along different velocity channels as well. Recently, Miville-Deschênes et al. (2016) have measured the intensity fluctuation power spectrum of the continuum dust emission, and found a power law behaviour with a power law index of $-2.9 \pm 0.1$ for a region of our Galaxy. Here, we study the same region using high-velocity resolution 21-cm emission from the diffuse neutral medium, and estimate the power spectrum at different spectral channels. The measured 21-cm power spectrum also follows a power law, however, we see a significant variation in the power law index with velocity. The value of the power-law index estimated from the integrated map for different components are quite different which is indicative of the different nature of turbulence depending on temperature, density and ionization fraction. We also measure the power spectra after smoothing the 21 cm emission to velocity resolution ranging from $1.03$ to $13.39~{\rm km~s^{-1}}$, but the power spectrum remains unchanged within the error bar. This indicates that the observed fluctuations are dominantly due to density fluctuations, and we can only constrain the power-law index of velocity structure function of $0.0 \pm 1.1$ which is consistent with the predicted Kolmogorov turbulence $(γ=2/3)$ and also with a shock-dominated medium $(γ=1.0)$.
description: 8 pages, 7 figures. Accepted for publication in MNRAS. The definitive version will be available at http://mnrasl.oxfordjournals.org/
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
Creators: name: Ecker, Veronika
name: Stumpf, Martina
name: Brandmeier, Lisa
name: Neumayer, Tanja
name: Pfeuffer, Lisa
name: Engleitner, Thomas
name: Ringshausen, Ingo
name: Nelson, Nina
name: Jücker, Manfred
name: Wanninger, Stefan
name: Zenz, Thorsten
name: Wendtner, Clemens
name: Manske, Katrin
name: Steiger, Katja
name: Rad, Roland
name: Müschen, Markus
name: Ruland, Jürgen
name: Buchner, Maike
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/67/1990/283/1895
/692/4028/67/1059
/13
/13/1
/13/31
/13/51
/13/89
/13/95
/38
/64
/64/110
article

description: Abstract: Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may be leveraged to trigger CLL cell death. Though counterintuitive, our data show that genetic hyperactivation of PI3K/AKT-signaling or blocking the activity of the inhibitory phosphatase SH2-containing-inositol-5′-phosphatase-1 (SHIP1) induces acute cell death in CLL cells. Our mechanistic studies reveal that increased AKT activity upon inhibition of SHIP1 leads to increased mitochondrial respiration and causes excessive accumulation of reactive oxygen species (ROS), resulting in cell death in CLL with immunogenic features. Our results demonstrate that CLL cells critically depend on mechanisms to fine-tune PI3K/AKT activity, allowing sustained proliferation and survival but avoid ROS-induced cell death and suggest transient SHIP1-inhibition as an unexpectedly promising concept for CLL therapy.