title: ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ ÐºÑÐ¸ÑÐµÑÐ¸ÐµÐ² Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ Ð½ÐµÑÐ²Ð½Ð¾-Ð¼ÑÑÐµÑÐ½Ð¾Ð¹ Ð¿ÐµÑÐµÐ´Ð°ÑÐ¸ Ð½Ð° ÑÐ¾Ð½Ðµ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐµÑÐ¸Ð»Ñ Ð¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ° Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 16.04.01 - Ð¢ÐµÑ Ð½Ð¸ÑÐµÑÐºÐ°Ñ ÑÐ¸Ð·Ð¸ÐºÐ° ; 16.04.01_13 - ÐÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ°Ñ ÑÐ¸Ð·Ð¸ÐºÐ°
titleType: Subtitle
Creators: name: ÐÐ°ÑÑÐ¾ÑÐ¾Ð²Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð°ÑÐµÑÐ¸Ð»Ñ Ð¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ
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description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ñ Ð½Ð° ÐºÑÑÑÐ°Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð¸Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ Ð½ÐµÑÐ²Ð½Ð¾-Ð¼ÑÑÐµÑÐ½Ð¾Ð¹ Ð¿ÐµÑÐµÐ´Ð°ÑÐ¸ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐµÑÐ¸Ð»ÑÐ¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð¹ ÑÑÐµÐ¿ÐµÐ½Ð¸. Ð£ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð°ÑÐµÑÐ¸Ð»ÑÐ¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ Ð½Ð° ÑÐ¾Ð½Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½ÐµÐ¾ÑÑÐ¸Ð³Ð¼Ð¸Ð½Ð° Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð²Ð°ÑÑÐ¸ÑÑÐµÑÑÑ Ð² ÑÐºÐµÐ»ÐµÑÐ½ÑÑ Ð¼ÑÑÑÐ°Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð°Ð½Ð°ÑÐ¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ Ð¾Ð±Ð»Ð°ÑÑÐµÐ¹ Ð¸ Ð¼Ð°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾ ÑÐ½Ð¸Ð¶Ð°ÐµÑÑÑ Ð² Ð¸ÐºÑÐ¾Ð½Ð¾Ð¶Ð½Ð¾Ð¹ Ð¼ÑÑÑÐµ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ½ÑÐµ Ð´Ð»Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð¹ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐµÑÐ¸Ð»ÑÐ¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ ÑÐ»ÐµÐºÑÑÐ¾Ð¼Ð¸Ð¾Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐµÐ½Ð¾Ð¼ÐµÐ½Ñ. Ð ÑÐµÑÑÐµ Ð¾Ð´Ð¸Ð½Ð¾ÑÐ½Ð¾Ð¹ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐµÑÐ¼ÐµÐ½ÑÐ° ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¾Ð²Ð°Ð»Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° Ð¿Ð¾Ð²ÑÐ¾ÑÐ½ÑÑ M-Ð¾ÑÐ²ÐµÑÐ¾Ð², Ð° Ð² ÑÐµÑÑÐµ ÑÐ¸ÑÐ¼Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ âÐ¿Ð¾ÑÐ²Ð»ÐµÐ½Ð¸Ðµ Ð´ÐµÐºÑÐµÐ¼ÐµÐ½Ñ-Ð¸Ð½ÐºÑÐµÐ¼ÐµÐ½ÑÐ½ÑÑ Ð¸ Ð´ÐµÐºÑÐµÐ¼ÐµÐ½ÑÐ½ÑÑ Ð¾ÑÐ²ÐµÑÐ¾Ð² Ð¿ÑÐ¸ ÑÐ°ÑÑÐ¾ÑÐµ 3-30 ÐÑ. ÐÑÑÐ²Ð»ÐµÐ½Ð½ÑÐµ Ð­ÐÐ-ÑÐµÐ½Ð¾Ð¼ÐµÐ½Ñ Ð¼Ð¾Ð³ÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ ÐºÑÐ¸ÑÐµÑÐ¸ÐµÐ² Ð¾ÑÐµÐ½ÐºÐ¸ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¹ Ð½ÐµÑÐ²Ð½Ð¾-Ð¼ÑÑÐµÑÐ½Ð¾Ð¹ Ð¿ÐµÑÐµÐ´Ð°ÑÐ¸ Ð¿ÑÐ¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ Ð¾Ð±ÑÐ°ÑÐ¸Ð¼ÑÑ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÐ¾ÑÐ¾Ð² Ð°ÑÐµÑÐ¸Ð»ÑÐ¾Ð»Ð¸Ð½ÑÑÑÐµÑÐ°Ð·Ñ Ð¸ Ð² Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµ Ð½ÐµÐ²ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹.
description: In work in experiments on rats using electromyography, disorders of neuromuscular transmission were studied under conditions of inhibition of acetylcholinesterase of various degrees. It is established that the activity of acetylcholinesterase on the background of the action of neostigmine varies considerably in skeletal muscles of various anatomical regions and decreases to the maximum in the gastrocnemius muscle. The study revealed electromyographic phenomena characteristic of various degrees of acetylcholinesterase inhibition. In the single stimulation test, an increase in the number of repeated M-responses corresponded to a decrease in the activity of the enzyme, and in the rhythmic stimulation test, the appearance of decrement-increment and decrement responses at a frequency of 3-30 Hz. Identified EMG phenomena can be used as criteria for assessing disorders of neuromuscular transmission in experimental studies of reversible acetylcholinesterase inhibitors and in the diagnosis of neurological diseases.