cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR -mutant gliomas
Creators: name: Noorani, Imran
name: De La Rosa, Jorge
name: Choi, Yoonha
name: Strong, Alexander
name: Ponstingl, Hannes
name: Vijayabaskar, M. S.
name: Lee, Jusung
name: Lee, Eunmin
name: Richard-Londt, Angela
name: Friedrich, Mathias
name: Furlanetto, Federica
name: Fuente, Rocio
name: Banerjee, Ruby
name: Yang, Fengtang
name: Law, Frances
name: Watts, Colin
name: Rad, Roland
name: Vassiliou, George
name: Kim, Jong Kyoung
name: Santarius, Thomas
name: Brandner, Sebastian
name: Bradley, Allan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research
Cancer Evolution and Metastasis

description: Funder: Wellcome Trust; doi: http://dx.doi.org/10.13039/100004440
description: Abstract: Background: Glioma is the most common intrinsic brain tumor and also occurs in the spinal cord. Activating EGFR mutations are common in IDH1 wild-type gliomas. However, the cooperative partners of EGFR driving gliomagenesis remain poorly understood. Results: We explore EGFR-mutant glioma evolution in conditional mutant mice by whole-exome sequencing, transposon mutagenesis forward genetic screening, and transcriptomics. We show mutant EGFR is sufficient to initiate gliomagenesis in vivo, both in the brain and spinal cord. We identify significantly recurrent somatic alterations in these gliomas including mutant EGFR amplifications and Sub1, Trp53, and Tead2 loss-of-function mutations. Comprehensive functional characterization of 96 gliomas by genome-wide piggyBac insertional mutagenesis in vivo identifies 281 known and novel EGFR-cooperating driver genes, including Cdkn2a, Nf1, Spred1, and Nav3. Transcriptomics confirms transposon-mediated effects on expression of these genes. We validate the clinical relevance of new putative tumor suppressors by showing these are frequently altered in patients’ gliomas, with prognostic implications. We discover shared and distinct driver mutations in brain and spinal gliomas and confirm in vivo differential tumor suppressive effects of Pten between these tumors. Functional validation with CRISPR-Cas9-induced mutations in novel genes Tead2, Spred1, and Nav3 demonstrates heightened EGFRvIII-glioma cell proliferation. Chemogenomic analysis of mutated glioma genes reveals potential drug targets, with several investigational drugs showing efficacy in vitro. Conclusion: Our work elucidates functional driver landscapes of EGFR-mutant gliomas, uncovering potential therapeutic strategies, and provides new tools for functional interrogation of gliomagenesis.
Comparative Transcriptome Analysis Q13 Demonstrates the Positive Effect of the Cyclic AMP Receptor Protein Crp on Daptomycin Biosynthesis in Streptomyces roseosporus
Creators: name: Jiequn Wu
name: Danqing Chen
name: Jinrong Wu
name: Xiaohe Chu
name: Yongmei Yang
name: Fang, Lina
name: Zhang, Wei
Publisher: name: figshare
Year: 2021
Subjects: Biological Engineering
Biological Techniques

description: Daptomycin, which is produced by Streptomyces roseosporus, has been characterized
as a novel cyclic lipopeptide antibiotic that is effective against Gram-positive bacteria.
The biosynthesis of daptomycin is regulated by various factors. In the present study,
we demonstrated that the cyclic AMP receptor protein (Crp) plays an important role in
producing daptomycin in the S. roseosporus industrial strain. We found that daptomycin
production from the crp deletion strain decreased drastically, whereas production from
the crp overexpression strain increased by 22.1%. Transcriptome and qPCR analyses
showed that some genes related to the daptomycin biosynthetic gene cluster (dpt) and
the pleiotropic regulator (adpA) were significantly upregulated. RNA-seq also shows
Crp to be a multifunctional regulator that modulates primary metabolism and enhances
precursor flux to secondary metabolite biosynthesis. These results provide guidance for
the development and improvement of potential natural products.
Teeth of Royalty from a burial in Jera Lompo’E, South Sulawesi, Indonesia
Creators: name: Universitas Gadjah Mada
Publisher: name: figshare
Year: 2019
Subjects: subject: Paleontology
subject: 160102 Biological (Physical) Anthropology
subject: FOS: Sociology

description: Teeth are one of the key to understand disease and cultural influence in the past. This research describes abnormalities and cultural influences found in teeth belongs to Addatuang Sidenreng which is a royalty buried in Jera Lompo'E, South Sulawesi, Indonesia (17th century). The material consists of 13 teeth which currently curated in Laboratory of Bioanthropology and Paleoanthropology, UGM, Indonesia. This research uses bioarchaeological method and macroscopical analysis. The results are the individual age estimation, health status and cultural influences, such as betel chewing and dental filing which still practiced even after Islam enters Sulawesi, Indonesia.
The Role of CDKs and CDKIs in Murine Development
Creators: name: Campbell, Grace Jean
name: Hands, Emma Langdale
name: Van De Pette, Mathew
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: cyclin-dependent kinase
CDK inhibitors
mouse
development
knock-out models

description: Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are essential for appropriate embryonic development. The twenty known mouse CDKs and eight CDKIs have been studied to varying degrees in the developing mouse, but only a handful of CDKs and a single CDKI have been shown to be absolutely required for murine embryonic development. What has become apparent, as more studies have shone light on these family members, is that in addition to their primary functional role in regulating the cell cycle, many of these genes are also controlling specific cell fates by directing differentiation in various tissues. Here we review the extensive mouse models that have been generated to study the functions of CDKs and CDKIs, and discuss their varying roles in murine embryonic development, with a particular focus on the brain, pancreas and fertility.
Additional file 1 of scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens
Creators: name: Yang, Lin
name: Zhu, Yuqing
name: Yu, Hua
name: Cheng, Xiaolong
name: Chen, Sitong
name: Chu, Yulan
name: Huang, He
name: Zhang, Jin
name: Li, Wei
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Supplementary figures, includingÂ Figure S1-S11 (PDF 3755 kb)
Distinct roles of Argonaute in the green alga Chlamydomonas reveal evolutionary conserved mode of miRNA-mediated gene expression
Creators: name: Chung, Betty Y.-W.
name: Valli, Adrian
name: Deery, Michael J.
name: Navarro, Francisco J.
name: Brown, Katherine
name: Hnatova, Silvia
name: Howard, Julie
name: Molnar, Attila
name: Baulcombe, David C.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/181
/631/337/384/331
/38/39
/45
/38
/45/43
article

description: Abstract: The unicellular green alga Chlamydomonas reinhardtii is evolutionarily divergent from higher plants, but has a fully functional silencing machinery including microRNA (miRNA)-mediated translation repression and mRNA turnover. However, distinct from the metazoan machinery, repression of gene expression is primarily associated with target sites within coding sequences instead of 3′UTRs. This feature indicates that the miRNA-Argonaute (AGO) machinery is ancient and the primary function is for post transcriptional gene repression and intermediate between the mechanisms in the rest of the plant and animal kingdoms. Here, we characterize AGO2 and 3 in Chlamydomonas, and show that cytoplasmically enriched Cr-AGO3 is responsible for endogenous miRNA-mediated gene repression. Under steady state, mid-log phase conditions, Cr-AGO3 binds predominantly miR-C89, which we previously identified as the predominant miRNA with effects on both translation repression and mRNA turnover. In contrast, the paralogue Cr-AGO2 is nuclear enriched and exclusively binds to 21-nt siRNAs. Further analysis of the highly similar Cr-AGO2 and Cr-AGO 3 sequences (90% amino acid identity) revealed a glycine-arginine rich N-terminal extension of ~100 amino acids that, given previous work on unicellular protists, may associate AGO with the translation machinery. Phylogenetic analysis revealed that this glycine-arginine rich N-terminal extension is present outside the animal kingdom and is highly conserved, consistent with our previous proposal that miRNA-mediated CDS-targeting operates in this green alga.
Conformal Invariance of Unitarity Corrections
Creators: name: Ewerz, Carlo
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study perturbative unitarity corrections in the generalized leading logarithmic approximation in high energy QCD. It is shown that the corresponding amplitudes with up to six gluons in the t-channel are conformally invariant in impact parameter space. In particular we give a new representation for the two-to-six reggeized gluon vertex in terms of conformally invariant functions. With the help of this representation an interesting regularity in the structure of the two-to-four and the two-to-six transition vertices is found.
description: 11 pages
Additional file 2 of scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens
Creators: name: Yang, Lin
name: Zhu, Yuqing
name: Yu, Hua
name: Cheng, Xiaolong
name: Chen, Sitong
name: Chu, Yulan
name: Huang, He
name: Zhang, Jin
name: Li, Wei
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Review history (DOCX 936 kb)
Estimating the Effect of Crop Insurance on Input Use When Insured Farmers are Monitored
Creators: name: He, Juan
name: Zheng, Xiaoyong
name: Rejesus, Roderick
name: Yorobe, Jose
name: He, Juan
name: Zheng, Xiaoyong
name: Rejesus, Roderick
name: Yorobe, Jose
Publisher: name: Unknown
Year: 2016
Subjects: subject: Crop Production/Industries
subject: Food Security and Poverty
subject: Industrial Organization
subject: Risk and Uncertainty
subject: Crop Insurance
subject: Monitoring
subject: Moral Hazard

description: Monitoring is one way to alleviate the moral hazard problem rampant in most crop insurance programs. Lacking explicit data on monitoring, we test the effectiveness of monitoring on reducing moral hazard behavior indirectly. We first propose a theoretical model that takes into account several features of the Philippines crop insurance program – the empirical setting of interest. Our model predicts that if monitoring is effective, then crop insurance should have a positive effect on the use of certain inputs. Our empirical analysis of a survey dataset of corn farmers in the Philippines confirms this theoretical prediction and lends empirical support to the hypothesis that monitoring is effective in reducing moral hazard behavior by the farmers.
Frame Dependence of Spin-One Angular Conditions in Light Front Dynamics
Creators: name: Bakker, B. L. G.
name: Ji, C. -R.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We elaborate the frame dependence of the angular conditions for spin-1 form factors. An extra angular condition is found in addition to the usual angular condition relating the four helicity amplitudes. Investigating the frame-dependence of the angular conditions, we find that the extra angular condition is in general as complicated as the usual one, although it becomes very simple in the $q^+ = 0$ frame involving only two helicity amplitudes. It is confirmed that the angular conditions are identical in frames that are connected by kinematical transformations. The high $Q^2$ behaviors of the physical form factors and the limiting behaviors in special reference frames are also discussed.
description: 29 pages RevTeX. submitted to Phys. Rev. D
One-body Properties of Nuclear Matter with Off-shell Propagation
Creators: name: Bozek, P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Symmetric nuclear matter is studied in the self-consistent, in-medium $T$-matrix approach. One-body spectral function, optical potential, and scattering width are calculated. Properties of quasi-particle excitations at the Fermi surface are discussed. Dispersive self-energies are dominated by contributions from the $^1S_0$, $3S_1-^3D_1$, and $^3P_1$ partial waves.
description: 10 pages, 9 figures
Auswirkung der Screeninguntersuchung auf die Prävalenz des Gestationsdiabetes mellitus und Überblick über die Qualität der Diabetesschwangerenbetreuung an der Universitätsfrauenklinik Rostock
Creators: name: Grünwald, Pavel
Publisher: name: Universität Rostock
Year: 2023
Subjects: subject: 610 Medical sciences Medicine

description: Es wurde der Einfluss der Screeninguntersuchung auf die Prävalenz des Gestationsdiabetes mellitus an der Universitätsfrauenklinik Rostock in einem retrospektiven Studiendesign untersucht. Ferner wurden zum Ziel der Qualitätssicherung von Diabetesschwangerschaften an der Klinik ausgewählte Parameter des maternalen und neonatalen Outcomes untersucht und mit aktuellen Behandlungsleitlinien und nationalen Perinatalerhebungen verglichen.
Curtonotum vulpinum Hendel 1913
Creators: name: Klymko, John
name: Marshall, Stephen A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Curtonotidae
Curtonotum
Curtonotum vulpinum

description: The Curtonotum vulpinum species complex
Figure 12
 Diagnosis. Species in the C. vulpinum species complex can be distinguished by the short lateral microtomentose strips on the frons that do not extend to the proclinate seta. The complex includes two described species (C. vulpinum Hendel and C. fumipenne Hendel) and at least seven new species.
 Comments. Many species in this complex appear indistinguishable without dissection. Several morphospecies closely resemble C. vulpinum, but without dissecting a C. vulpinum type specimen none could be identified as that species. No specimens of C. fumipenne were available for dissection, so it could not be included in the phylogenetic analysis although it does possess the shortened microtomentose frontal markings that define the complex.
 Species in the C. vulpinum species complex range from southern Mexico to northeastern Bolivia. This species complex is under study though a revision is in a preliminary stage.
description: Published as part of Klymko, John & Marshall, Stephen A., 2011, Systematics of New World Curtonotum Macquart (Diptera: Curtonotidae) 3079, pp. 1-110 in Zootaxa 3079 (1) on page 64, DOI: 10.11646/zootaxa.3079.1.1, http://zenodo.org/record/5243925
D-Brane Solutions from New Isometries of pp-Waves
Creators: name: Alishahiha, Mohsen
name: Kumar, Alok
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use recently proposed translations isometries of pp-waves to construct D4 and D3 brane solutions, using T-duality transformations, in exactly solvable pp-wave background originating from $AdS_3\times S^3$ geometry. A unique property of the new brane solutions is the breaking of SO(10-p-1) symmetry in the transverse direction of the branes due to the presence of constant NS-NS and R-R background fluxes. We verify that the our `localized' solutions satisfy the field equations and explicitly present the corresponding Killing spinors. We also show the connection of our results to certain M5-branes in pp-wave geometry.
description: 14 pages, references added, some typos corrected: minor corrections
Transcriptional activity and strain-specific history of mouse pseudogenes
Creators: name: Sisu, Cristina
name: Muir, Paul
name: Frankish, Adam
name: Fiddes, Ian
name: Diekhans, Mark
name: Thybert, David
name: Odom, Duncan T.
name: Flicek, Paul
name: Keane, Thomas M.
name: Hubbard, Tim
name: Harrow, Jennifer
name: Gerstein, Mark
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/114/2401
/631/114/2785
/631/136/334/1874/345
/631/208/212/2304
/45/91
/64/60
article

description: Abstract: Pseudogenes are ideal markers of genome remodelling. In turn, the mouse is an ideal platform for studying them, particularly with the recent availability of strain-sequencing and transcriptional data. Here, combining both manual curation and automatic pipelines, we present a genome-wide annotation of the pseudogenes in the mouse reference genome and 18 inbred mouse strains (available via the mouse.pseudogene.org resource). We also annotate 165 unitary pseudogenes in mouse, and 303, in human. The overall pseudogene repertoire in mouse is similar to that in human in terms of size, biotype distribution, and family composition (e.g. with GAPDH and ribosomal proteins being the largest families). Notable differences arise in the pseudogene age distribution, with multiple retro-transpositional bursts in mouse evolutionary history and only one in human. Furthermore, in each strain about a fifth of all pseudogenes are unique, reflecting strain-specific evolution. Finally, we find that ~15% of the mouse pseudogenes are transcribed, and that highly transcribed parent genes tend to give rise to many processed pseudogenes.
Does the Adoption of Weather Tolerant Variety Contribute to Reduction in Rice Yield Loss? Panel Data Survey from Chinese Rice Farmers
Creators: name: Tang, Liqun
name: Zhou, Jiehong
name: Yu, Xiaohua
name: Tang, Liqun
name: Zhou, Jiehong
name: Yu, Xiaohua
Publisher: name: Unknown
Year: 2016
Subjects: subject: Crop Production/Industries
subject: Food Security and Poverty
subject: Production Economics
subject: Climate extremes
subject: rice
subject: weather tolerant variety
subject: yield

description: Climate extremes, characterized by droughts and floods, have become one of the major constraints to sustainable improvement of rice productivity. Variety choice, considered as one of the main adaptation measures, could help farmers reduce yield loss resulting from these extremes. Based on a three-year panel survey of 1,080 Chinese rice farms in major rice producing provinces, we study the effect of adopting weather tolerant variety rice as a main adaptation measure against climate extremes. Taking into account the endogeneity of adoption behavior, we employ an endogenous switching regression to separately estimate the treatment effects of adoption for adopters and non-adopters. We find that farmers who adopted the new variety increased yield by 537 kg/ha (about 7%), compared with the counterfactual case of no-adoption. In contrast, the farmers who did not adopt, would increase rice yield by 272 kg/ha (about 4 %) if they adopted, much smaller than the adopters. However, adoption of new variety demands more knowledge, better education, more intensive management, and higher seed costs. As a policy implication, expansion of public extension services could help relax these restrictions.
Additional file 4 of Improved bioethanol productivity through gas flow rate-driven self-cycling fermentation
Creators: name: Wang, Jie
name: Chae, Michael
name: Bressler, David
name: Sauvageau, Dominic
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Additional file 4: Table S1. Comparison between batch and SCF operation under similar conditions.
Material selection for optimum design of MEMS pressure sensors
Creators: name: Mehmood, Zahid
name: Haneef, Ibraheem
name: Udrea, Florin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Technical Paper

description: Abstract: Choice of the most suitable material out of the universe of engineering materials available to the designers is a complex task. It often requires a compromise, involving conflicts between different design objectives. Materials selection for optimum design of a Micro-Electro-Mechanical-Systems (MEMS) pressure sensor is one such case. For optimum performance, simultaneous maximization of deflection of a MEMS pressure sensor diaphragm and maximization of its resonance frequency are two key but totally conflicting requirements. Another limitation in material selection of MEMS/Microsystems is the lack of availability of data containing accurate micro-scale properties of MEMS materials. This paper therefore, presents a material selection case study addressing these two challenges in optimum design of MEMS pressure sensors, individually as well as simultaneously, using Ashby’s method. First, data pertaining to micro-scale properties of MEMS materials has been consolidated and then the Performance and Material Indices that address the MEMS pressure sensor’s conflicting design requirements are formulated. Subsequently, by using the micro-scale materials properties data, candidate materials for optimum performance of MEMS pressure sensors have been determined. Manufacturability of pressure sensor diaphragm using the candidate materials, pointed out by this study, has been discussed with reference to the reported devices. Supported by the previous literature, our analysis re-emphasizes that silicon with 110 crystal orientation [Si (110)], which has been extensively used in a number of micro-scale devices and applications, is also a promising material for MEMS pressure sensor diaphragm. This paper hence identifies an unexplored opportunity to use Si (110) diaphragm to improve the performance of diaphragm based MEMS pressure sensors.
DO EDUCATION LEVELS MATTER ON INDONESIAN ECONOMIC GROWTH?
Creators: name: Universitas Gadjah Mada
Publisher: name: figshare
Year: 2019
Subjects: subject: 140202 Economic Development and Growth
subject: FOS: Economics and business

description: Arising from the questions “Would all types of human capital affect economic growth identically? And which type of schooling - primary, secondary, or tertiary – should public policy promote?”, this study examines the nexus between different educational levels and Indonesia’s economic growth over a reference period 1984-2014. During this period, education expansion took place at all three levels of education reflecting structural changes tied within the policies under the Millennium Development Goals (MDG’s) as the key and powerful factor for sustainable economic development. The study applies the augmented Lucas endogenous growth model and employs the autoregressive distributed lag model. The empirical analysis reveals a long-run relation between education and economic growth. The estimated long-run and short-run elasticity of different education levels reveal that, overall, human capital structure in Indonesia is still at the stage of promoting economic growth and identifies tertiary education as the main level for development. The findings reveal that education level matters to economic growth. Further, the empirical evidence helps shed light on why empirical studies have failed to find a significant relationship between schooling and economic growth.
An Evaluation of Factors Influencing Consumer Purchase Decisions of Cut Flowers: A Study of Washington Consumers
Creators: name: Li, Zongyu
name: McCracken, Vicki
name: Connolly, Jenny
name: Li, Zongyu
name: McCracken, Vicki
name: Connolly, Jenny
Publisher: name: Unknown
Year: 2016
Subjects: Agribusiness

description: In 2013, USDA statistics indicate that at the wholesale level, 80% of fresh flowers sold in the United States are not grown in North America, but imported from other countries. Shipping flowers from those countries to the United States incurs large transportation, energy, refrigeration, and storage costs, leaving an enormous carbon footprint. These floral materials may carry residue of chemical pesticides or fungicides. Washington State is among the top ten cut flower producing states in recent years. As competition with international growers has increased the structure of the WA industry has changed resulting in more small-scale producers growing specific flowers that aren’t easily imported. Small-scale cut flower producers are mostly selling their produce directly to consumers. Fresh fruits and vegetables tend to be the most important food categories for products sold at farmers’ markets, which is one of the most popular ways for direct sales to consumers. Cut flowers are also frequently sold directly to consumers, particularly at farmers’ markets. In this study we are using a WA consumer survey to identify factors influencing consumers’ purchase decisions for cut flowers, separating the analyses into flowers purchased for personal use and for a gift. By identifying differences between purchase decision for personal use and for gift can help producers better identify market opportunities and barriers. Results Preliminary results indicate that factors affecting purchases for personal use are not exactly same as those affecting purchases for gift use. Some factors (e.g. age, income and garden ownership) had similar impacts on both types of purchase decisions. Both purchase decisions were positively impacted by the information that the cut flower was grown in Washington. Looking at the differences between the two purchase decisions, we found consumer knowledge about cut flowers affected cut flower purchase decision for personal use but not for gift use. And factors important in the purchase decision for gift use only were gender and education. All else constant, consumers more likely to buy cut flowers for gift use were males, at higher education levels, and who valued variety in cut flowers. However, consumers more likely to buy cut flowers for personal were married, and had correct knowledge about how to keep cut flower last longer.
Response Surface Methodology to Optimize the Isolation of Dominant Volatile Compounds from Monofloral Greek Thyme Honey using SPME-GC-MS
Creators: name: Xagoraris, Marinos
name: Skouria, Alexandra
name: Panagiota-Kyriaki Revelou
name: Alissandrakis, Eleftherios
name: Tarantilis, Petros A.
name: Pappas, Christos S.
Publisher: name: Zenodo
Year: 2021

description: Figure S1: Box-cox plot of benzaldehyde. Figure S2: Box-cox plot of 2-phenylacetaldehyde. Figure S3: Box-cox plot of undecane. Figure S4: Box-cox plot of nonanal. Figure S5: Box-cox plot of 2-phenylethan-1-ol. Figure S6: Box-cox plot of 2-phenylacetonitrile. Figure S7: Box-cox plot of 1-phenylbutane-2.3dione. Figure S8: Box-cox plot of methyl nonanoate. Figure S9: Box-cox plot of 3-hydroxy-4-phenyl-2-butanone. Figure S10: Box-cox plot of (Z)-3-hydroxy-4-phenylbut-3-en-2-one. Table S1: Design layout runs.
How do bound star clusters form?
Creators: name: Krumholz, Mark R.
name: McKee, Christopher F.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Gravitationally-bound clusters that survive gas removal represent an unusual mode of star formation in the Milky Way and similar spiral galaxies. While forming, they can be distinguished observationally from unbound star formation by their high densities, virialised velocity structures, and star formation histories that accelerate toward the present, but extend multiple free-fall times into the past. In this paper we examine several proposed scenarios for how such structures might form and evolve, and carry out a Bayesian analysis to test these models against observed distributions of protostellar age, counts of young stellar objects relative to gas, and the overall star formation rate of the Milky Way. We show that models in which the acceleration of star formation is due either to a large-scale collapse or a time-dependent increase in star formation efficiency are unable to satisfy the combined set of observational constraints. In contrast, models in which clusters form in a "conveyor belt" mode where gas accretion and star formation occur simultaneously, but the star formation rate per free-fall time is low, can match the observations.
description: MNRAS in press; 20 pages, 7 figures in main text (36 pages, 21 figures including online-only appendix); source code available at https://bitbucket.org/krumholz/km19; compared to previous version, this version has some additional analysis and models, but the primary conclusions are unchanged
Characterization of Semi-Interpenetrated Network Alginate/Gelatin Wound Dressing Crosslinked at Sol Phase
Creators: name: Universitas Gadjah Mada
Publisher: name: figshare
Year: 2019
Subjects: Nuclear Chemistry
Nuclear Engineering

description: Gel contraction of alginate during ionic crosslinking at sol phase was reduced by blending with gelatin solution due to intermolecular interaction and chain entanglement. The semi-interpenetrated network (semi-IPN) of wound dressing hydrogels were prepared by overlaid alginate/gelatin blend with 1.0% (w/w) CaCl2 solution under ambient temperature for 2 h. Results showed that gel contraction was significantly reduced with increasing gelatin content i.e. from 40.5 ± 5.8% for pure alginate to as low as 5.8 ± 1.2% for alginate/gelatin of 1:7 (w/w). It seems that gelatin successfully inhibited alginate chains mobility during their network re-arrangement by a Ca2+ cation. The FTIR spectra of hydrogels showed a combination of characteristic vibration of alginate and gelatin. Increasing gelatin content also significantly improved elasticity and tensile strength at break of dried hydrogels. Swelling kinetics of dried hydrogels were fitted with Schott’s second-order power-law model. Increasing gelatin fraction increased the swelling rate while decreased the swelling at equilibrium. Their absorptive capacity was of the interval for management of moderate to heavily exudating wound.
title: Ansätze für die Mobilitäts- und Energiewende im städtischen Güterverkehr
Creators: name: Leerkamp, Bert
Publisher: name: TU Wien
Year: 2021
Subjects: Letzte Meile
gebietsbezogene Bündelung
Stadtlogistik
KEP
Stückgut

description: Derzeit verfolgte Bündelungsstrategien im städtischen Wirtschaftsverkehr schöpfen das Potenzial ei-ner gebietsbezogenen Fahrleistungseinsparung und der damit verbundenen Reduktion negativer Umweltwirkungen nicht aus. Die aktive Mitwirkung des Handels und der privaten Endverbraucher kann eine weitgehende gebietsbezogene Bündelung von KEP- und Stückgutsendungen bewirken. Das kooperative Logistikkonzept ABC Incharge in Düsseldorf zeigt beispielhaft, dass ein solcher Ansatz unter den derzeitigen Rahmenbedingungen wirtschaftlich tragfähig sein kann. Den Kommunen stehen demgegenüber nur wenige Instrumente zur Verfügung, um Bündelungskonzepte zu initiieren. Von starken Markteingriffen durch die Vergabe von Gebietskonzessionen in Anlehnung an die Abfallwirtschaft wird dennoch abgeraten. Die Beschleunigung der Energiewende im städtischen Güterverkehr wird damit umso dringlicher. Die Kommunen sollten Niedrig- und Nullemissionszonen planen und mit angemessener Vorlaufzeit umsetzen, um die Flottenerneuerung im Nutzfahrzeugsektor zu forcieren. Ein ausreichendes Logistikflächenangebot in den Kernstädten ist ein Beitrag, um gebietsbezogene Bündelung wirtschaftlich zu ermöglichen und steigenden Reichweitenanforderungen der Lieferfahrzeuge zu begegnen. Komplementär dazu muss das kommunale Mittelspannungsstromnetz schnell ausgebaut werden.
description: Current Sustainable Urban Logistic Plans (SULP) focus on reorganising last mile delivery by using micro depots and cargo bikes. Consolidation ist a key for successful concepts both in economic and ecologic terms. Local planning authorities often focus on area-based consolidation for the inner city and densely populated urban areas while logistic service providers (LSP) focus on optimising delivery in their indi-vidual catchment area. While only few governmental instruments are available to force area-based consolidation strategies, cooperation between LSP and local commerce is an option to generate sub-stantial effects on reduction of distance driven, emissions and retention time of light and heavy trucks in the inner city. An ongoing project in Düsseldorf shows, how the segments general cargo and parcel (CEP) can be consolidated. Zero Emission Zones and comparable measures can support cooperation between the economic agents.
Inter-generational Effects of Early Childhood Shocks on Human Capital: Evidence from Ethiopia
Creators: name: Tafere, Kibrom
name: Tafere, Kibrom
Publisher: name: Unknown
Year: 2016
Subjects: subject: International Development
subject: Labor and Human Capital
subject: Childhood shocks
subject: Inter-generational transmission of shocks
subject: famine
subject: human capital
subject: Ethiopia

description: In this paper I investigate the impacts of parental early childhood shocks on the human capital of children using various measures of health capabilities, schooling achievements, and standardized math and Peabody Picture Vocabulary Test (PPVT) test scores. I use parents' age during the 1983-85 Ethiopian famine, geographic variation of the famine, and the duration of exposure to identify effects. This paper uses the Ethiopia Young Lives panel survey of children who were tracked from the age of 6-18 months over an 11 year period. I find that children born to mothers who were exposed to the famine in their first 3 years have poor health endowments, lower schooling achievement and perform poorly in standardized tests.
description: This is a preliminary work. Please do not cite.
HIV and syphilis testing behaviors among heterosexual male and female sex workers in Uganda
Creators: name: Muhindo, Richard
name: Mujugira, Andrew
name: Castelnuovo, Barbara
name: Sewankambo, Nelson K.
name: Parkes-Ratanshi, Rosalind
name: Kiguli, Juliet
name: Tumwesigye, Nazarius Mbona
name: Nakku-Joloba, Edith
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research
HIV
Syphilis
Testing
Male sex workers
Uganda

description: Funder: Janssen Pharmaceuticals (US)
description: Abstract: Background: In Sub-Saharan Africa where HIV disproportionately affects women, heterosexual male sex workers (HMSW) and their female clients are at risk of acquiring or transmitting HIV and other STIs. However, few studies have described HIV and STI risk among HMSW. We aimed to assess and compare recent HIV and syphilis screening practices among HMSW and female sex workers (FSW) in Uganda. Methods: Between August and December 2019, we conducted a cross-sectional study among 100 HMSW and 240 female sex workers (FSW). Participants were enrolled through snowball sampling, and an interviewer-administered questionnaire used to collect data on HIV and syphilis testing in the prior 12 and 6 months respectively. Integrated change model constructs were used to assess intentions, attitudes, social influences, norms and self-efficacy of 3-monthly Syphilis and 6-monthly HIV testing. Predictors of HIV and syphilis recent testing behaviors were estimated using negative binomial regression. Results: We enrolled 340 sex workers of whom 100 (29%) were HMSW. The median age was 27 years [interquartile range (IQR) 25–30] for HMSW and 26 years [IQR], (23–29) for FSW. The median duration of sex work was 36 and 30 months for HMSW and FSW, respectively. HMSW were significantly less likely than FSW to have tested for HIV in the prior 12 months (50% vs. 86%; p = 0.001). For MSW, non-testing for HIV was associated with higher education [adjusted prevalence ratio (aPR) 1.66; 95% confidence interval (CI) 1.09–2.50], poor intention to seek HIV testing (aPR 1.64; 95% CI 1.35–2.04), perception that 6-monthly HIV testing was not normative (aPR 1.33; 95% CI 1.09–1.67) and low self-efficacy (aPR 1.41; 95% CI 1.12–1.79). Not testing for syphilis was associated with low intention to seek testing (aPR 3.13; 95% CI 2.13–4.55), low self-efficacy (aPR 2.56; 95% CI 1.35–4.76), negative testing attitudes (aPR 2.33; 95% CI 1.64–3.33), and perception that regular testing was not normative (aPR 1.59; 95% CI 1.14–2.22). Conclusions: Non-testing for HIV and syphilis was common among HMSW relative to FSW. Future studies should evaluate strategies to increase testing uptake for this neglected sub-population of sex workers.
Supplementary document for Real time and high-precision online determination of main components in iron ore using spectral refinement algorithm based LIBS - 6665293.pdf
Creators: name: liu, ruibin
name: an, li
name: Zhang, Xinyu
name: Liu, Xiaodong
name: He, Yage
name: Shan, Yuheng
name: sun, Haohan
name: Yi, Wen
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Optical Physics not elsewhere classified

description: Supplemental 1
The Role of Sauropus androgynus (L.) Merr. Leaf Powder in the Broiler Chickens Fed a Diet Naturally Contaminated with Aflatoxin
Creators: name: Universitas Gadjah Mada
Publisher: name: figshare
Year: 2019
Subjects: subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Aflatoxin (AF) is the secondary metabolite of Aspergillus flavus and commonly contaminates feed during storage.AF causes lowered growth rate, stress, and increased mortality in the poultry, especially for broiler industries.The aims of this study are to determine the effects of Sauropus androgynus (L.) Merr. leaf powder (SAP) in the chickens fed a diet naturally contaminated with AF. A total of 108 chickens are divided into 6 group: group I fed with basal diet (AF not detectable); group II fed with basal diet (AF not detectable) + 5%SAP; group III with AF (>1 ppb <50 ppb); group IVwithAF (>1 ppb <50ppb) + 5% SAP; groupVwithAF (>51 ppb <100 ppb) + 5%SAP; group VI with AF (>101 ppb <150 ppb) + 5% SAP.The data of the body weight, feed intake and efficiency, the relative weight of liver, kidney, spleen, bursa of Fabricius (BF), histopathology, haematological profile, haemagglutination inhibition (HI) titer, AF residue, and immunohistochemistry are collected on days 7, 14, and 21. All the data were analysed using SPSS 16. The supplementation of 5%SAPin the chickens fed a diet naturally contaminated withAFshowed the potential effects of the bodyweight performance, haematological profile protection, increase in the cellular and humoral immune responses, reduction of AF residue in the organ, protection of liver, kidney, spleen, and BF histopathology, and increase in the immune-expression of CD4+/CD8+ lymphocytes ratio (P < 0.05). It shows that 5% SAP can be used as the alternative herbal supplementation to depress the impacts of aflatoxicosis in the broiler chickens.
Tracking Kidnappings in London: Offenders, Victims and Motives
Creators: name: Surtees, Keith
name: Tankebe, Justice
name: Bland, Matthew
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Original Article
Kidnap
Targeting
Tracking
Evidence-based policing

description: Funder: University of Cambridge
description: Abstract: Research Question: What was the nature of kidnappings in London during a fairly recent 5-year period in the kinds of victims, offenders, motives, types of violence used and levels of injury? Data: We analyse 924 reports of kidnap crimes recorded by the Metropolitan Police Service between 1 April 2006 and 31 March 2011. These data included free text information drawn from case notes. Methods: We establish mutually exclusive categories of kidnappings by codifying all crime records, after examining case notes and populated fields from the Metropolitan Police’s crime recording system. Descriptive statistics are used to portray the patterns and nature of these crimes. Findings: The application of a typology of mutually exclusive categories for these kidnappings shows that gangland/criminal/drugs-related cases comprised 40.5% of all kidnappings. Another 21% of all kidnaps were domestic or familial, including honour killings. Just over 10% were incidental to ‘acquisitive’ crimes such as car-jacking, whilst 8% were sexually motivated. Only 6% were categorised as traditional ransom kidnappings. About 4% were categorised into a purely violent category, whilst 3% were categorised as international/political. Conclusions: The investigative and preventive implications of these many social worlds mapped out by this typology are substantial. Each social context may require investigators to possess expertise in the specific social world of kidnapping, as distinct from what might be called expertise in ‘kidnaps’ per se. Investigations and prevention might be re-engineered around targeted intelligence from these diverse social contexts.
How Does Time Use Differ between Individuals Who Do More versus Less Foodwork? A Compositional Data Analysis of Time Use in the United Kingdom Time Use Survey 2014–2015
Creators: name: Clifford Astbury, Chloe
name: Foley, Louise
name: Penney, Tarra L.
name: Adams, Jean
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: foodwork
home food preparation
compositional data analysis
time-use data

description: Background: Increased time spent on home food preparation is associated with higher diet quality, but a lack of time is often reported as a barrier to this practice. We compared time use in individuals who do more versus less foodwork (tasks required to feed ourselves and our households, including home food preparation). Methods: Cross-sectional analysis of the UK Time Use Survey 2014−15, participants aged 16+ (N = 6143). Time use over 24 h was attributed to seven compositional parts: personal care; sleep; eating; physical activity; leisure screen time; work (paid and unpaid); and socialising and hobbies. Participants were categorised as doing no, ‘some’ (70 min), or ‘more’ foodwork (≥70 min). We used compositional data analysis to test whether time-use composition varied between these participant groups, determine which of the parts varied between groups, and test for differences across population subgroups. Results: Participants who spent more time on foodwork spent less time on sleep, eating, and personal care and more time on work. Women who did more foodwork spent less time on personal care, socialising, and hobbies, which was not the case for men. Conclusion: Those who seek to encourage home food preparation should be aware of the associations between foodwork and other activities and design their interventions to guard against unintended consequences.
Glauber versus Kawasaki for spectral gap and logarithmic Sobolev inequalities of some unbounded conservative spin systems
Creators: name: Chafai, Djalil
Publisher: name: arXiv
Year: 2002
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 60K35; 82B44; 82B20; 46-99; 60J60; 26D10

description: Inspired by the recent results of C. Landim, G. Panizo and H.-T. Yau [LPY] on spectral gap and logarithmic Sobolev inequalities for unbounded conservative spin systems, we study uniform bounds in these inequalities for Glauber dynamics of Hamiltonian of the form V(x_1) + ... + V(x_n) + V(M-x_1 -...-x_n), (x_1,...,x_n) in R^n Specifically, we examine the case V is strictly convex (or small perturbation of strictly convex) and, following [LPY], the case V is a bounded perturbation of a quadratic potential. By a simple path counting argument for the standard random walk, uniform bounds for the Glauber dynamics yields, in a transparent way, the classical L^{-2} decay for the Kawasaki dynamics on d-dimensional cubes of length L. The arguments of proofs however closely follow and make heavy use of the conservative approach and estimates of [LPY], relying in particular on the Lu-Yau martingale decomposition and clever partitionings of the conditional measure.
description: 20 pages. Accepted for publication in ``Markov Processes and Related Fields''
title: Strategien der Dekommodifizierung
title: Zum transformativen Potenzial lokaler marktferner Eigentumsmodelle
titleType: AlternativeTitle
Creators: name: Horlitz, Sabine
Publisher: name: TU Wien
Year: 2021
Subjects: gemeinschaftliches Wohnen

description: Gegenwärtig kann von einer Renaissance der Eigentumsfrage in der kritischen Stadtforschung gesprochen werden. Die vielfältigen Debatten – von der Boden- und Immobilienspekulation in urbanen Zentren über das Landgrabbing im Agrarsektor bis zur fortgesetzten Privatisierung und Inwertsetzung vormals öffentlicher Dienstleistungen und Güter – schärfen den Blick auf Eigentum als gesellschaftlich treibende Kraft (Nuss: 2019, Zeller: 2004). Die damit verbundenen Fragen des Ein- bzw. Ausschlusses, der Verteilungsungerechtigkeiten und Verknappung von Ressourcen, aber auch die demokratietheoretischen Probleme, die eine Konzentration von Eigentum und ökonomischer Macht hervorrufen, sind zentrale Themen gegenwärtiger stadtpolitischer Debatten. Das vermeintlich dingliche Eigentum zeigt sich hier, anders als im Alltagsverständnis, nicht als Sache oder Objekt, sondern als soziales Verhältnis, als – in den Worten des Rechtswissenschaftlers David Friedmann (2000) – ein Bündel von Rechten und Berechtigungen, das die Beziehungen und das Handeln zwischen Menschen, Institutionen und Gütern regelt. Das im Eigentumsrecht formalisierte soziale Verhältnis besteht jedoch nicht per se, sondern ist durch die Dynamiken von Politik, Wirtschaft, Gesellschaft und Kultur bestimmt und als grundsätzlich veränderbar zu denken. Im Kontext der gegenwärtigen Eigentumsdebatten gibt es eine Reihe verschiedener Ansätze der Konzeptualisierung von Alternativen. Diese reichen von der Analyse neuer Möglichkeiten der Profitbegrenzungen (beispielsweise durch eine neue Wohnungsgemeinnützigkeit), der Forderung nach der Besteuerung (und damit der Umverteilung) sogenannter leistungsloser Gewinne aus der Schaffung von Planungs- und Baurecht über die Bestrebungen zur Rekommunalisierung vormals privatisierter Dienste und Liegenschaften bis zur Suche nach einem anderen theoretischen Rechts- und Eigentumsverständnis, beispielsweise in der Commonsforschung. Zu dieser Suchbewegung möchte dieser Text mit der Analyse verschiedener nicht gewinnorientierter Eigentumsmodelle einen Beitrag leisten. Ihm liegt die Annahme zugrunde, dass eine dauerhafte soziale Orientierung von Grund und Boden sowie der darauf befindlichen Nutzungen nicht auf individueller Ebene möglich ist, sondern nur durch die Schaffung kollektiver marktferner Strukturen und entsprechender Sicherungs- bzw. Kontrollmechanismen erreicht werden kann.
Indirect Search for Neutralino Dark Matter with High Energy Neutrinos
Creators: name: Barger, Vernon
name: Halzen, Francis
name: Hooper, Dan
name: Kao, Chung
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the prospects of indirect searches for supersymmetric neutralino dark matter. Relic neutralinos gravitationally accumulate in the Sun and their annihilations produce high energy neutrinos. Muon neutrinos of this origin can be seen in large detectors like AMANDA, IceCube and ANTARES. We evaluate the relic density and the detection rate in several models---the minimal supersymmetric model, minimal supergravity, and supergravity with non-universal Higgs boson masses at the grand unification scale. We make realistic estimates for the indirect detection rates including effects of the muon detection threshold, quark hadronization, and solar absorption. We find good prospects for detection of neutralinos with mass above 200 GeV.
description: 36 pages in REVTEX, 18 figures