cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
PtSi Clustering In Silicon Probed by Transport Spectroscopy
Creators: name: Mongillo, Massimo
name: Spathis, Panayotis
name: Katsaros, Georgios
name: Rurali, Riccardo
name: Cartoixa, Xavier
name: Gentile, Pascal
name: de Franceschi, Silvano
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Metal silicides formed by means of thermal annealing processes are employed as contact materials in microelectronics. Control of the structure of silicide/silicon interfaces becomes a critical issue when the device characteristic size is reduced below a few tens of nanometers. Here we report on silicide clustering occurring within the channel of PtSi/Si/PtSi Schottky barrier transistors. This phenomenon is investigated through atomistic simulations and low-temperature resonant tunneling spectroscopy. Our results provide evidence for the segregation of a PtSi cluster with a diameter of a few nanometers from the silicide contact. The cluster acts as metallic quantum dot giving rise to distinct signatures of quantum transport through its discrete energy states.
Therapeutic Silencing of KRAS Using Systemically Delivered siRNAs
Creators: name: Sood, A. K.
name: Filant, J.
name: Dalton, H. J.
name: Ellis, L. M.
name: Kopetz, S.
name: Waugh, T. A.
name: Zand, B.
name: Bellister, S.
name: Nagaraja, A. S.
name: Morelli, M. P.
name: Gonzalez-Villasana, V.
name: Gharpure, K. M.
name: Pecot, C. V.
name: Azam, S.
name: Maharaj, A.
name: Bhattacharya, R.
name: Lopez-Berestein, G.
name: Rupaimoole, R.
name: Rodriguez-Aguayo, C.
name: Hisamatsu, T.
name: Wu, S. Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Despite being amongst the most common oncogenes in human cancer, to date there are no effective clinical options for inhibiting KRAS activity. We investigated whether systemically delivered KRAS siRNAs have therapeutic potential in KRAS mutated cancer models. We identified KRAS siRNA sequences with notable potency in knocking-down KRAS expression. Using lung and colon adenocarcinoma cell lines, we assessed anti-proliferative effects of KRAS silencing in vitro. For in vivo experiments, we used a nano-liposomal delivery platform, DOPC, for systemic delivery of siRNAs. Various lung and colon cancer models were utilized to determine efficacy of systemic KRAS siRNA based on tumor growth, development of metastasis and down-stream signaling. KRAS siRNA sequences induced >90% knock-down of KRAS expression, significantly reducing viability in mutant cell lines. In the lung cancer model, KRAS siRNA treatment demonstrated significant reductions in primary tumor growth and distant metastatic disease, while the addition of CDDP was not additive. Significant reductions in Ki-67 indices were seen in all treatment groups, while significant increases in caspase-3 activity was only seen in the CDDP treatment groups. In the colon cancer model, KRAS siRNA reduced tumor KRAS and pERK expression. KRAS siRNAs significantly reduced HCP1 subcutaneous tumor growth, as well as outgrowth of liver metastases. Our studies demonstrate a proof-of-concept approach to therapeutic KRAS targeting using nanoparticle delivery of siRNA. This study highlights the potential translational impact of therapeutic RNA interference, which may have broad applications in oncology, especially for traditional “undruggable” targets.
Extended bodies in a Kerr spacetime: exploring the role of a general quadrupole tensor
Creators: name: Bini, Donato
name: Geralico, Andrea
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The equatorial motion of extended bodies in a Kerr spacetime is investigated in the framework of the Mathisson-Papapetrou-Dixon model, including the full set of effective components of the quadrupole tensor. The numerical integration of the associated equations shows the specific role of the mass and current quadrupole moment components. While most of the literature on this topic is limited to spin-induced (purely electric) quadrupole tensor, the present analysis highlights the effect of a completely general quadrupole tensor on the dynamics. The contribution of the magnetic-type components is indeed related to a number of interesting features, e.g., enhanced inward/outward spiraling behavior of the orbit and spin-flip-like effects, which may have observational counterparts. Finally, the validity limit of the Mathisson-Papapetrou-Dixon model is also discussed through explicit examples.
description: 18 pages, 6 figures; published version. arXiv admin note: text overlap with arXiv:1311.7512
Quantum chaos and level dynamics
Creators: name: Zakrzewski, Jakub
Publisher: name: arXiv
Year: 2023
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We review application of level dynamics to spectra of quantally chaotic systems. We show that statistical mechanics approach gives us predictions about level statistics intermediate between integrable and chaotic dynamics. Then we discuss in detail different statistical measures involving level dynamics such as level avoided-crossing distributions, slope and curvature of level distributions showing both the postulate of unversality and its limitations. We mention shortly the experimental confirmations of these theories. We concentrate in some detail on measures imported from quantum information approach such as the fidelity susceptibility and more generally geometric tensor matrix elements. The possible open problems are suggested.
description: short review dedicated to prof. Giulio Casati on the occasion of his 80th birthday
Detecting event-related recurrences by symbolic analysis: Applications to human language processing
Creators: name: Graben, Peter beim
name: Hutt, Axel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Quasistationarity is ubiquitous in complex dynamical systems. In brain dynamics there is ample evidence that event-related potentials reflect such quasistationary states. In order to detect them from time series, several segmentation techniques have been proposed. In this study we elaborate a recent approach for detecting quasistationary states as recurrence domains by means of recurrence analysis and subsequent symbolisation methods. As a result, recurrence domains are obtained as partition cells that can be further aligned and unified for different realisations. We address two pertinent problems of contemporary recurrence analysis and present possible solutions for them.
description: 24 pages, 6 figures. Draft version to appear in Proc Royal Soc A
Dekanatsrechnung vom Juni 1589 bis Juni 1590
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1589

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Probing the non-locality of Majorana fermions via quantum correlations
Creators: name: Li, Jun
name: Yu, Ting
name: Lin, Hai-Qing
name: You, J. Q.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Majorana fermions (MFs) are exotic particles that are their own anti-particles. Recently, the search for the MFs occurring as quasi-particle excitations in solid-state systems has attracted widespread interest, because of their fundamental importance in fundamental physics and potential applications in topological quantum computation based on solid-state devices. Here we study the quantum correlations between two spatially separate quantum dots induced by a pair of MFs emerging at the two ends of a semiconductor nanowire, in order to develop a new method for probing the MFs. We find that without the tunnel coupling between these paired MFs, quantum entanglement cannot be induced from an unentangled (i.e., product) state, but quantum discord is observed due to the intrinsic nonlocal correlations of the paired MFs. This finding reveals that quantum discord can indeed demonstrate the intrinsic non-locality of the MFs formed in the nanowire. Also, quantum discord can be employed to discriminate the MFs from the regular fermions. Furthermore, we propose an experimental setup to measure the onset of quantum discord due to the nonlocal correlations. Our approach provides a new, and experimentally accessible, method to study the Majorana bound states by probing their intrinsic non-locality signature.
description: 6 pages, 3 figures
OJ~287: a new BH mass estimate of the secondary
Creators: name: Titarchuk, Lev
name: Seifina, Elena
name: Shrader, Chris
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We presented a study of outburst activity in the BL Lacertae source OJ~287, observed extensively with the X-ray telescope (XRT) onboard Neil Gehrels Swift Observatory. We demonstrated that the results of our analysis of X-ray flaring activity using the Swift/XRT data allow to refine the key characteristics of the OJ~287 secondary (its nature and mass). We discovered that the energy spectra in all spectral states can be fitted using the XSPEC Bulk Motion Comptonization (BMC) model. As a result we found that the X-ray photon index of the BMC model, Gamma correlates with the mass accretion rate, dot. We established that Gamma increases monotonically with dot from the low-hard state, Gamma~ 1.5 to the high-soft state, Gamma~2.8 and finally saturates. The index behavior was similar to that in a number of black hole (BH) candidates in which we showed that its saturation was an observational evidence of the presence of a BH. Based on this correlation, we applied a scaling method and determined that a secondary BH mass in OJ~287 is about ~1.25x10^8 solar masses, using the well-studied X-ray BH binaries XTE~1550--564, H~1743--322, 4U~1630--47, GRS~1915+105 as well as extragalactic BHs ESO~243--49 and M101~ULX--1, as reference sources. Also using the power spectrum analysis we inferred the size of the Compton cloud L_{CC}~ 10^{13} cm where X-ray spectra were formed. Using this value of L_{CC} we confirmed that a BH mass of the secondary in OJ~287 was of order of 10^8 solar masses as we derived using the index, Gamma-correlation (the scaling method) with respect of the mass accretion rate.
description: 10 pages, 8 figures
Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer
Creators: name: Bazyar, S.
name: Miller, C. R.
name: Zamboni, W.
name: Lee, Y. Z.
name: O'Neal, S.
name: Sambade, M. J.
name: Nikolaishvili-Feinberg, N.
name: Adamo, B.
name: Anders, C. K.
name: Karginova, O.
name: Santos, C.
name: Darr, D.
name: Van Swearingen, A. E. D.
name: Deal, A. M.
name: Bash, R.
name: Parker, J. S.
name: Siegel, M. B.
name: Sandison, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently harbors BRCA mutations translating to platinum sensitivity potentially augmented by additional suppression of DNA repair mechanisms through poly(ADP-ribose)polymerase (PARP) inhibition. We evaluated brain penetrance and efficacy of Carboplatin +/− the PARP inhibitor ABT888, and investigated gene expression changes in murine intracranial (IC) TNBC models stratified by BRCA and molecular subtype status.
Aufstellung von Arztkosten und sonstigen Ausgaben von Basilius Amerbach
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1557

description: Entstanden vermutlich während des Studienaufenthalts von Basilius Amerbach in Bourges 1557-1559
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Consumption of cyanobacteria by freshwater zooplankton: implications for the success of 'top-down' control of cyanobacterial blooms in Australia
Creators: name: Boon, Paul I
name: Bunn, Stuart E
name: Green, John D
name: Shiel, Russell J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Two main approaches have been mooted for the management of fresh waters to prevent or control cyanobacterial blooms: a 'bottom-up' approach in which the supply of essential nutrients is restricted, and a 'top-down' or 'biomanipulation' approach in which attempts are made to restructure the food web to maximize consumption of noxious cyanobacteria by herbivorous zooplankton. In this review, the published literature is examined to gauge whether the common zooplankton of Australian fresh waters have the capacity to control cyanobacterial blooms, especially of toxic forms, and thus whether the biomanipulation approach might be applied successfully in Australia. As zooplankton assemblages in Australian inland waters are quite different in composition from those of the Northern Hemisphere, they are unlikely to respond to manipulations of trophic structure in a similar way. The most common zooplankters in Australian inland waters, calanoid copepods and rotifers, have less potential for controlling cyanobacterial blooms than do large cladocerans. The latter are common in the Northern Hemisphere and are considered requisite for the control of cyanobacterial blooms. Toxic cyanobacteria, which cause the most severe environmental problems, have well documented detrimental effects on zooplankton. The few reports of zooplankton grazing on cyanobacteria in Australian fresh waters do not indicate that native zooplankton can consume noxious cyanobacteria at the rates required for control of algal blooms. There may, therefore, be grounds for strong reservations about the likely success of programmes proposed to control cyanobacterial blooms by the manipulation of trophic structure in Australian fresh waters.
Rektoratsrechnung vom Juni 1563 bis Juni 1564
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1563

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status
Creators: name: Frye, S. V.
name: Earp, H. S.
name: Cummings, C. T.
name: Zhang, D.
name: Graham, D. K.
name: DeRyckere, D.
name: Wang, X.
name: Zhang, W.
name: Davies, K. D.
name: Kirkpatrick, G. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Treatment of non-small cell lung cancer (NSCLC) has been transformed by targeted therapies directed against molecular aberrations specifically activated within an individual patient’s tumor. However, such therapies are currently only available against a small number of such aberrations, and new targets and therapeutics are needed. Our laboratory has previously identified the MERTK receptor tyrosine kinase (RTK) as a potential drug target in multiple cancer types, including NSCLC. We have recently developed UNC2025 – the first-in-class small molecule inhibitor targeting MERTK with pharmacokinetic properties sufficient for clinical translation. Here we utilize this compound to further validate the important emerging biologic functions of MERTK in lung cancer pathogenesis, to establish that MERTK can be effectively targeted by a clinically translatable agent, and to demonstrate that inhibition of MERTK is a valid treatment strategy in a wide variety of non-small cell lung cancer cell lines independent of their driver oncogene status, including in lines with an EGFR mutation, a KRAS/NRAS mutation, an RTK fusion, or another or unknown driver oncogene. Biochemically, we report the selectivity of UNC2025 for MERTK, and its inhibition of oncogenic downstream signaling. Functionally, we demonstrate that UNC2025 induces apoptosis of MERTK-dependent NSCLC cell lines, while decreasing colony formation in vitro and tumor xenograft growth in vivo in murine models. These findings provide further evidence for the importance of MERTK in NSCLC, and demonstrate that MERTK inhibition by UNC2025 is a feasible, clinically relevant treatment strategy in a wide variety of NSCLC sub-types, which warrants further investigation in clinical trials.
Convective gas flow in Eleocharis sphacelata R. Br.: methane transport and release from wetlands
Creators: name: Sorrell, Brian K
name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

We investigated the importance of lacunar gas transport for the release of methane from beds of Eleocharis sphacelata R. Br. in a freshwater wetland in southeastern Australia. Gases were transported in the E. sphacelata lacunar system by pressurized convective flow, which was apparently driven by humidity induced pressurization. Internal culm temperatures were 1.9–4.2° C lower than at the external culm surface, suggesting that thermal transpiration was not responsible for lacunar pressurization. Some of the culms (influx culms) provide a net gas flux from the atmosphere into the plant, whereas others (efflux culms) act as conduits for flux from the rhizosphere to the atmosphere. The mean gas influx was 1.0±0.2 (SE) ml min−1 per culm, and the mean gas efflux was 0.2±0.0 (SE) ml min−1 per culm. The difference in influx and efflux flow rates is due to unequal numbers of the two culm types, and the total gas flux through three adjacent E. sphacelata beds was estimated from this flow ratio and the total culm density. It ranged from 1.1 to 2.5 1 m−2 h−1. The methane concentration in the efflux culms was 2–3%, resulting in a total methane efflux from E. sphacelata of 22–75 ml CH4 m−2 h−1. These rates represented 1–15 times the rate of methane release from the E. sphacelata beds by ebullition of methane in bubbles released from the sediment. Diffusive methane fluxes in the lacunar s system (< 300 μl m−2 h−1) were an insignificant mechanism of methane release compared with lacunar convective flow and ebullition fluxes from sediments. The interstitial methane concentration in sediments from E. sphacelata beds was approximately 0.6 times that of adjacent unvegetated sediment, highlighting the role of convective flow by E. sphacelata in accelerating methane release from sediments.
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms
Creators: name: Bang, Yung-Jue
name: Maddileti, Savitri
name: Shutes, Adam
name: Juliano, Rudolph L.
name: Der, Channing J.
name: Harden, T. Kendall
name: Healy, Kevin D.
name: Hodgson, Louis
name: Hahn, Klaus M.
name: Kim, Tai-Young
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multidomain protein that includes a Rho GTPase Activating Protein (RhoGAP) domain which has been hypothesized to be the basis of its tumor suppressive actions. To address the importance of the RhoGAP function of DLC-1 in tumor suppression, we performed biochemical and biological studies evaluating DLC-1 in NSCLC. Full length DLC-1 exhibited strong GAP activity for RhoA as well as RhoB and RhoC, but only very limited activity for Cdc42 in vitro. In contrast, the isolated RhoGAP domain showed 5- to 20-fold enhanced activity for RhoA, RhoB, RhoC and Cdc42. DLC-1 protein expression was absent in six of nine NSCLC cell lines. Restoration of DLC-1 expression in DLC-1-deficient NSCLC cell lines reduced RhoA activity, and experiments with a RhoA biosensor demonstrated that DLC-1 dramatically reduces RhoA activity at the leading edge of cellular protrusions. Furthermore, DLC-1 expression in NSCLC cell lines impaired both anchorage-dependent and -independent growth, as well as invasion in vitro. Surprisingly, we found that the anti-tumor activity of DLC-1 was due to both RhoGAP-dependent and -independent activities. Unlike the rat homologue p122RhoGAP, DLC-1 was not capable of activating the phospholipid hydrolysis activity of phospholipase C-δ1. Combined, these studies provide information on the mechanism of DLC-1 function and regulation, and further support the role of DLC-1 tumor suppression in NSCLC.
Aufstellung der Ausgaben von Basilius Amerbach für seine Sammlung in den Jahren 1562-1591
Creators: name: Iselin, Ludwig
Publisher: name: [s.n.]
Year: 1591
Subjects: Amerbach, Basilius1533-1591BasiliusAmerbach

description: Sammler
description: Ludwig Iselin
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Druck: Beiträge zu Basilius Amerbach / Elisabeth Landolt ... [et al.]. - Basel : Öffentliche Kunstsammlung, 1991 (Sammeln in der Renaissance. Das Amerbachkabinett ; Bd. 5). - S. 279-285
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Giant Dipole Resonance as a Fingerprint of $α$ Clustering Configurations in $^{12}$C and $^{16}$O
Creators: name: He, W. B.
name: Ma, Y. G.
name: Cao, X. G.
name: Cai, X. Z.
name: Zhang, G. Q.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: It is studied how the $α$ cluster degrees of freedom, such as $α$ clustering configurations close to the $α$ decay threshold in $^{12}$C and $^{16}$O, including the linear chain, triangle, square, kite, and tetrahedron, affect nuclear collective vibrations with a microscopic dynamical approach, which can describe properties of nuclear ground states well across the nuclide chart and reproduce the standard giant dipole resonance (GDR) of $^{16}$O quite nicely. It is found that the GDR spectrum is highly fragmented into several apparent peaks due to the $α$ structure. The different $α$ cluster configurations in $^{12}$C and $^{16}$O have corresponding characteristic spectra of GDR. The number and centroid energies of peaks in the GDR spectra can be reasonably explained by the geometrical and dynamical symmetries of $α$ clustering configurations. Therefore, the GDR can be regarded as a very effective probe to diagnose the different $α$ cluster configurations in light nuclei.
description: 6 pages, 3 figures
Unified statistical distribution of quantum particles and Symmetry
Creators: name: Abutaleb, Ahmad Adel
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: In this paper we propose a unified statistics of Bose-Einstein and Fermi-Dirac statistics by suggesting that every particle can be associated with matter or fundamental forces with certain probability. The main Justification for this proposal is the possibility of extension of the spin-statistics theory to include a hypothesis quantum particles have fractional spin. The concept of Supersymmetry can be related to this unified statistics.
description: 8 pages, 9 figures . Any scientific comments are so welcome
Polymorphisms in drug metabolism genes, smoking, andp53 mutations in breast cancer
Creators: name: Perrier, Nancy D.
name: Van Emburgh, Beth O.
name: Sawyer, Lynda R.
name: Knight, Sommer N.
name: Hu, Jennifer J.
name: Sherrill, Gary B.
name: Milikowski, Clara
name: Rubin, Peter
name: Carey, Lisa A.
name: Willingham, Mark C.
name: Shaw, Cindy S.
name: Levine, Edward A.
name: Mosley, Libyadda J.
name: Case, L. Douglas
name: Lin, Hui-Yi
name: Allen, Glenn O.
name: Miller, Mark Steven
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Polymorphisms in phase I and phase II enzymes may enhance the occurrence of mutations at critical tumor suppressor genes, such as p53, and increase breast cancer risk by either increasing the activation or detoxification of carcinogens and/or endogenous estrogens. We analyzed polymorphisms in CYP1B1, GSTM1, GSTT1, and GSTP1 and p53 mutations in 323 breast tumor samples. Approximately 11% of patients exhibited mutations in p53. Women with mutations had a significantly younger age of diagnosis (P = 0.01) and a greater incidence of tumors classified as stage II or higher (P = 0.002). More women with mutations had a history of smoking (55%) compared to women without mutations (39%). Although none of the genotypes alone were associated with p53 mutations, positive smoking history was associated with p53 mutations in women with the GSTM1 null allele [OR = 3.54; 95% CI = 0.97–12.90 P = 0.06] compared to women with the wild-type genotype and smoking history [OR = 0.62, 95% CI = 0.19–2.07], although this association did not reach statistical significance. To test for gene–gene interactions, our exploratory analysis in the Caucasian cases suggested that individuals with the combined GSTP1 105 VV, CYP1B1 432 LV/VV, and GSTM1 positive genotype were more likely to harbor mutations in p53 [OR = 4.94; 95% CI = 1.11–22.06]. Our results suggest that gene–smoking and gene–gene interactions may impact the prevalence of p53 mutations in breast tumors. Elucidating the etiology of breast cancer as a consequence of common genetic polymorphisms and the genotoxic effects of smoking will enable us to improve the design of prevention strategies, such as lifestyle modifications, in genetically susceptible subpopulations.
Zusammenstellung von Sehenswürdigkeiten in Oberitalien auf der Route über den Brenner
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1553

description: Gefaltetes Quartblatt
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Aus der Werkstatt der Amerbach-Edition / Ueli Dill, Beat Rudolf Jenny. - Basel : Schwabe, 2000. - S. 331
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Discrimination of algal and bacterial alkaline phosphatases with a differential-inhibition technique
Creators: name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Both phytoplankton and bacterioplankton produce alkaline phosphatases, but the techniques currently available for discriminating between the two sources are poor, especially when samples are from turbid waters. A novel approach, based on the differential inhibition of alkaline phosphatases by various physical and chemical treatments, was assessed as a rapid and inexpensive technique for determining whether phytoplankton or bacterioplankton were the more important producers of alkaline phosphatases in turbid rivers of south-eastern Australia. Eight phytoplankton strains and 14 bacterial strains (eight isolated from the Ovens River and six isolated as bacterial contaminants of the phytoplankton cultures) were grown in laboratory culture. Rates of alkaline phosphatase activity in the bacterial cultures varied from <1 to 21 fmol cell-1 day -1. Rates for phytoplankton were usually < 5µmol (µg chla) -1 day-1 but could reach 128 µmol (µ chla)-1 day-1, depending on whether inorganic or organic phosphorus was supplied. Differential-inhibition profiles were determined for the 22 isolates, using seven chemical treatments (L-cysteine, EDTA and L-levamisole, and Zn2+ and Cu2+ each at two concentrations) plus one physical treatment (thermal deactivation). The alkaline phosphatases of the three microbial groups (i.e. Ovens River bacteria, bacteria isolated as contaminants from algal cultures, and phytoplankton) could be classified with a predictive accuracy of better than 90% when these data were analysed with Discriminant Function Analysis. L-Cysteine, Zn2+ and Cu2+ were the best predictors of class membership; thermal deactivation and EDTA sometimes were also significant. Inhibition profiles were then determined for the alkaline phosphatases of various river-water samples. These environmental samples usually (>70% of cases) grouped separately from those of the laboratory cultures of bacteria and phytoplankton, perhaps because the microbes studied in laboratory culture were not representative of native assemblages or because the culture conditions did not mimic those in nature. Nevertheless, differential-inhibition techniques have much potential for determining the origin of the alkaline phosphatases found in natural waters, with the major factor limiting their application being the collection of valid inhibition profiles for native bacterial and algal communities.
Rechnung für Stoffe
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1624
Subjects: Burckhardt, Samuel
Iselin, Basilius1611-1648BasiliusIselein

description: Ausgestellt für den Tuchhändler Samuel Burckhardt, Vogt von Basilius Iselin
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Ratschlag zur Verhinderung des Wegzugs von Johannes Buxtorf d.Ä. nach Leiden
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1625
Subjects: Buxtorf, Johann1564-1629JohannBuxtorf

description: Universität
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
A Rallying Framework for Impact and Change: The UN Sustainable Development Goals in the Canadian Fundraising Landscape (November 2022)
Creators: name: Philanthropic Inc. (Canada), Global
name: Malcolm, Dionne
name: Osipov, Igor
Publisher: name: figshare
Year: 2022
Subjects: subject: 160605 Environmental Politics
subject: FOS: Political science
subject: 160507 Environment Policy
subject: 169901 Gender Specific Studies
subject: FOS: Sociology
subject: 220102 Business Ethics
subject: FOS: Philosophy, ethics and religion
subject: Environmental Humanities
subject: Gender studies
subject: Climate Science
subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences
subject: 50101 Ecological Impacts of Climate Change
subject: FOS: Earth and related environmental sciences
subject: 50203 Environmental Education and Extension
subject: 160506 Education Policy
subject: 160508 Health Policy

description: Using a variety of research methods, Global Philanthropic Inc. (Canada) set out to understand the role SDGs are playing within the Canadian fundraising landscape today, seven years after their creation. We wanted to hear the voice of the philanthropic community.
 Through survey data, interviews and research from organizations across the country, varying in size, scope and mission, we are able to paint a qualitative and quantitative picture of how SDGs have begun to permeate our work in philanthropic fundraising. We also gathered meaningful case studies and quotes on how fundraisers and fundraising organizations can meaningfully use the SDGs to benefit the work they do now, and in the future.
Extinction of Taurus, Orion, Perseus and California Molecular Clouds Based on the LAMOST, 2MASS and Gaia surveys I: Three-dimensional Extinction and Structure
Creators: name: Cao, Zhetai
name: Jiang, Biwei
name: Zhao, He
name: Sun, Mingxu
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The three-dimensional extinction and structure are studied for the Taurus, Orion, Perseus and California molecular clouds based on the LAMOST spectroscopy. Stellar color excess is calculated with the intrinsic color index derived from the atmospheric parameters in the LAMOST DR8 catalog and the observed color index in the Gaia EDR3 and the 2MASS PSC. In combination with the distance from the Gaia EDR3 parallax, the three-dimensional dust extinction maps are retrieved in the color excesses $E_{\rm{G_{BP},G_{RP}}}$ and $E_{\rm{J,K_{S}}}$ with an uncertainty of $\sim$0.03mag and $\sim$0.07mag respectively. The extinction maps successfully separate the clouds that overlap in the sky area and manifest the structure of the individual cloud. Meanwhile, a bow-like structure is found with a distance range from 175pc to 250pc, half of which is a part of the Per-Tau Shell in similar coordinates and distance while the other half is not. Three low-extinction rings are additionally discovered and briefly discussed.
description: 22 pages, 15 figures, 2 tables, accepted for publication in ApJ
Rektoratsrechnung vom Mai 1540 bis Mai 1541
Creators: name: Amerbach, Bonifacius
Publisher: name: [s.n.]
Year: 1540

description: Universität
description: Bonifacius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5 +/â ; p53 +/â mice
Creators: name: Roberts, Charles W.M.
name: DelBove, Jessica
name: Mora-Blanco, E. Lorena
name: Kuwahara, Yasumichi
name: Weissman, Bernard E.
name: Van Dyke, Terry
name: Funkhouser, William K.
name: Godfrey, Virginia
name: Fletcher, Christopher D.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Malignant rhabdoid tumors (MRTs) are poorly differentiated pediatric cancers that arise in various anatomical locations and have a very poor outcome. The large majority of these malignancies are caused by loss of function of the SNF5/INI1 component of the SWI/SNF chromatin remodeling complex. However, the mechanism of tumor development associated with SNF5 loss remains unclear. Multiple studies have demonstrated a role for SNF5 in the regulation of cyclin D1, p16INK4A and pRbf activities suggesting it functions through the SWI/SNF complex to affect transcription of genes involved in cell cycle control. Previous studies in genetically engineered mouse models (GEMM) have shown that loss of SNF5 on a p53 null background significantly accelerates tumor development. Here, we use established GEMM to further define the relationship between the SNF5 and p53 tumor suppressor pathways. Combined haploinsufficiency of p53 and Snf5 leads to decreased latency for MRTs arising in alternate anatomical locations but not for the standard facial MRTs. We also observed acceleration in the appearance of T-cell lymphomas in the p53+/-;Snf5+/- mice. Our studies suggest that loss of SNF5 activity does not bestow a selective advantage on the p53 spectrum of tumors in the p53+/-;Snf5+/- mice. However, reduced p53 expression specifically accelerated the growth of a subset of MRTs in these mice.
Brief an Johannes Buxtorf d.J
Creators: name: Spanheim, Friedrich
Publisher: name: [s.n.]
Year: 1646

description: Berufung von Johannes Buxtorf d.J. auf den Lehrstuhl für Hebraistik an der Universität Leiden
description: von Friedrich Spanheim
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Drosophila MUS312 Interacts with the Nucleotide Excision Repair Endonuclease MEI-9 to Generate Meiotic Crossovers
Creators: name: Majumder, Samarpan
name: Sekelsky, Jeff J
name: Yildiz, Özlem
name: Kramer, Benjamin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: AbstractMEI-9 is the Drosophila homolog of the human structure-specific DNA endonuclease XPF. Like XPF, MEI-9 functions in nucleotide excision repair and interstrand crosslink repair. MEI-9 is also required to generate meiotic crossovers, in a function thought to be associated with resolution of Holliday junction intermediates. We report here the identification of MUS312, a protein that physically interacts with MEI-9. We show that mutations in mus312 elicit a meiotic phenotype identical to that of mei-9 mutants. A missense mutation in mei-9 that disrupts the MEI-9–MUS312 interaction abolishes the meiotic function of mei-9 but does not affect the DNA repair functions of mei-9. We propose that MUS312 facilitates resolution of meiotic Holliday junction intermediates by MEI-9.
Height and the total mass of the forest of genealogical trees of a large population with general competition
Creators: name: Le, Vi
name: Pardoux, Etienne
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60J80, 60J85, 92D25

description: We consider branching processes with interaction in continuous time, both with values in the integers and in the reals (in the second case we restrict ourselves to continuous processes), which model the evolution of the size of a population. We assume that for large population size the interaction is of the type of a competition, which limits the size of the population. We discuss in which cases the interaction is strong enough so that the extinction time (or equivalently the height of the forest of genealogical trees) remains finite, as the number of ancestors tends to infinity, or even such that the length of the forest of genealogical trees (which in the case of continuous state is rather called its total mass) remains finite, as the ancestral population size tends to infinity.
description: ESAIM: Probability and Statistics, 2014
Vertebrate POLQ and POLβ Cooperate in Base Excision Repair of Oxidative DNA Damage
Creators: name: Nakamura, Jun
name: Arakawa, Hiroshi
name: Yasui, Akira
name: Seki, Mineaki
name: Hochegger, Helfrid
name: Hiraoka, Masahiro
name: Takeda, Shunichi
name: Buerstedde, Jean-Marie
name: Wilson, Samuel H.
name: Prasad, Rajendra
name: Hou, Esther
name: Kohzaki, Masaoki
name: Okada, Takashi
name: Lan, Li
name: Tano, Keizo
name: Yoshimura, Michio
name: Asagoshi, Kenjiro
name: Sonoda, Eiichiro
name: Wood, Richard D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Base excision repair (BER) plays an essential role in protecting cells from mutagenic base damage caused by oxidative stress, hydrolysis, and environmental factors. POLQ is a DNA polymerase, which appears to be involved in translesion DNA synthesis (TLS) past base damage. We disrupted POLQ, and its homologs HEL308 and POLN in chicken DT40 cells, and also created polq/hel308 and polq/poln double mutants. We found that POLQ-deficient mutants exhibit hypersensitivity to oxidative base damage induced by H2O2, but not to UV or cisplatin. Surprisingly, this phenotype was synergistically increased by concomitant deletion of the major BER polymerase, POLβ. Moreover, extracts from a polq null mutant cell line show reduced BER activity, and POLQ, like POLβ, accumulated rapidly at sites of base damage. Accordingly, POLQ and POLβ share an overlapping function in the repair of oxidative base damage. Taken together, these results suggest a role for vertebrate POLQ in BER.
Microstructural diversity, nucleation paths and phase behaviour in binary mixtures of charged colloidal spheres
Creators: name: Lorenz, Nina
name: Gupta, Ishan
name: Palberg, Thomas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study low-salt, binary aqueous suspensions of charged colloidal spheres of size ratio Phi = 0.57, number densities below the eutectic number density n_E, and number fractions of p = 1.00-0.40. The typical phase obtained by solidification from a homogeneous shear-melt is a substitutional alloy of body centred cubic structure. In strictly gas-tight vials, the polycrystalline solid is stable against melting and further phase transformation for extended times. For comparison, we prepare the same samples also by slow and mechanically undisturbed deionization in commercial slit cells. These cells feature a complex but well reproducible sequence of global and local gradients in salt concentration, number density and composition as induced by successive deionization, phoretic transport and differential settling of the components, respectively. Moreover, they provide an extended bottom surface suitable for heterogeneous nucleation of the beta-phase. We give a detailed qualitative characterization of the crystallization processes using imaging and optical microscopy. By contrast to the bulk samples, the initial alloy formation in slit cells is not volume-filling, and we now observe also alpha- and beta-phases with low solubility of the odd component. In addition to the initial homogeneous nucleation route, the interplay of gradients opens various further crystallization and transformation pathways leading to a great diversity of microstructures. Upon subsequent increase in salt concentration, crystals melt again. Wall-based, pebble-shaped beta-phase crystals and facetted alpha-crystals melt last. Our observations suggest that the substitutional alloys formed in bulk experiments by homogeneous nucleation and subsequent growth are mechanically stable in the absence of solid-fluid interfaces but thermodynamically metastable.
description: Submitted to J Chem Phys. Revised version after forst Referee round. 50p, 21 figures, mainly high res. micrographs
Abrechnung über den Aufbau einer Bibliothek der Juristischen Fakultät
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1589

description: Universität
description: Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
NIRwave: A wave-turbulence-driven solar wind model constrained by PSP observations
Creators: name: Schleich, Simon
name: Saikia, Sudeshna Boro
name: Ziegler, Udo
name: Güdel, Manuel
name: Bartel, Michael
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: We generate a model description of the solar wind based on an explicit wave-turbulence-driven heating mechanism, and constrain our model with observational data. We included an explicit coronal heating source term in the general 3D magnetohydrodynamic code NIRVANA to simulate the properties of the solar wind. The adapted heating mechanism is based on the interaction and subsequent dissipation of counter-propagating Alfvén waves in the solar corona, accounting for a turbulent heating rate Q_p. The solar magnetic field is assumed to be an axisymmetric dipole with a field strength of 1 G. Our model results are validated against observational data taken by the Parker Solar Probe (PSP). Our NIRwave solar wind model reconstructs the bimodal structure of the solar wind with slow and fast wind speeds of 410 km/s and 650 km/s respectively. The global mass-loss rate of our solar wind model is 2.6e-14 solar masses per year. Despite implementing simplified conditions to represent the solar magnetic field, the solar wind parameters characterising our steady-state solution are in reasonable agreement with previously established results and empirical constraints. The number density from our wind solution is in good agreement with the derived empirical constraints, with larger deviations for the radial velocity and temperature. In a comparison to a polytropic wind model generated with NIRVANA, we find that our NIRwave model is in better agreement with the observational constraints that we derive.
description: 14 pages, 12 figures, accepted for publication in A&A
Testament von Juliana Amerbach
Creators: name: Amerbach, Juliana
name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1560

description: verfasst von Basilius Amerbach
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Direct measurements of growing amorphous order and non-monotonic dynamic correlations in a colloidal glass-former
Creators: name: Nagamanasa, K. Hima
name: Gokhale, Shreyas
name: Sood, A. K.
name: Ganapathy, Rajesh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: While the transformation of flowing liquids into rigid glasses is omnipresent, a complete understanding of vitrification remains elusive. Of the numerous approaches aimed at solving the glass transition problem, the Random First-Order Theory (RFOT) is the most prominent. However, the existence of the underlying thermodynamic phase transition envisioned by RFOT remains debatable, since its key microscopic predictions concerning the growth of amorphous order and the nature of dynamic correlations lack experimental verification. Here, by using holographic optical tweezers, we freeze a wall of particles in an equilibrium configuration of a 2D colloidal glass-forming liquid and provide direct evidence for growing amorphous order in the form of a static point-to-set length. Most remarkably, we uncover the non-monotonic dependence of dynamic correlations on area fraction and show that this non-monotonicity follows directly from the change in morphology of cooperatively rearranging regions, as predicted by RFOT. Our findings suggest that the glass transition has a thermodynamic origin.
Polar molecule reactive collisions in quasi-1D systems
Creators: name: Simoni, Andrea
name: Srinivasan, Srihari
name: Launay, Jean-Michel
name: Jachymski, Krzysztof
name: Idziaszek, Zbigniew
name: Julienne, Paul S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We study polar molecule scattering in quasi-one-dimensional geometries. Elastic and reactive collision rates are computed as a function of collision energy and electric dipole moment for different confinement strengths. The numerical results are interpreted in terms of first order scattering and of adiabatic models. Universal dipolar scattering is also discussed. Our results are relevant to experiments where control of the collision dynamics through one dimensional confinement and an applied electric field is envisioned.
description: 25 pages, 13 figures
title: Did the Covid-19 pandemic create poverty in France? (LIEPP Policy Brief, n°65 bis)
Creators: name: Bouchet, Célia
name: Duvoux, Nicolas
Publisher: name: Sciences Po - LIEPP
Year: 2023
Subjects: classificationCode: 5
subject: FOS: Social sciences

description: The French Statistical Institute estimates that the monetary poverty rate was stable between 2019 and 2020, while several scientific and associative contributions note significant socioeconomic difficulties among some groups during the Covid­19 pandemic. Using a secondary analysis of nine quantitative and qualitative surveys collected by the National Council for Policies to Combat Poverty and Social Exclusion (CNLE) in 2021, we show that several social groups were exposed to precariousness of varying format, chronology and mechanisms. We develop implications for poverty measures, welfare inequalities, non­governmental solidarities and temporalities of poverty policies.