cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles
Creators: name: Wang, Haipeng
name: Sun, Shuilin
name: Zhang, Yu
name: Wang, Jiayi
name: Zhang, Shouhua
name: Yao, Xuebing
name: Chen, Ling
name: Gao, Zhen
name: Xie, Baogang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Background: To prepare sorafenib-loaded folate-decorated bovine serum nanoparticles (FA-SRF-BSANPs) and investigate their effect on the tumor targeting. Methods: The nanoparticles were characterized and evaluated by in vivo and in vitro experiments. Results: SRF-loaded BSA nanoparticles (SRF-BSANPs) was first prepared and modified with folic acid by chemical coupling to obtain FA-SRF-BSANPs. The average particle size, zeta potential, entrapment efficiency, and drug loading of the optimized FA-SRF-BSANPs were 158.00 nm, −16.27 mV, 77.25%, and 7.73%, respectively. The stability test showed that FA-SRF-BSANPs remained stable for more than 1 month at room temperature. The TEM analysis showed that the surface of FA-SRF-BSANPs was nearly spherical. XRD analysis showed that the drug existed in. the nanoparticles in an amorphous state. FA-SRF-BSANPs can promote the intracellular uptake of hepatoma cells (SMMC-7721) with the strongest inhibitory effect compared with SRF-BSANPs and sorafenib solution. Furthermore, the tumor targeting of FA-SRF-BSANPs (Ctumor/Cblood, 0.666 ± 0.053) was significantly higher than those of SRF-BSANPs (Ctumor/Cblood, 0.560 ± 0.083) and sorafenib-solution (Ctumor/Cblood, 0.410 ± 0.038) in nude mice with liver cancer. Conclusion: FA-modified albumin nanoparticles are good carriers for delivering SRF to the tumor tissue, which can improve the therapeutic effect and reduce the side effects of the drug.
The Parallel Complexity of Growth Models
Creators: name: Machta, J.
name: Greenlaw, R.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: This paper investigates the parallel complexity of several non-equilibrium growth models. Invasion percolation, Eden growth, ballistic deposition and solid-on-solid growth are all seemingly highly sequential processes that yield self-similar or self-affine random clusters. Nonetheless, we present fast parallel randomized algorithms for generating these clusters. The running times of the algorithms scale as $O(\log^2 N)$, where $N$ is the system size, and the number of processors required scale as a polynomial in $N$. The algorithms are based on fast parallel procedures for finding minimum weight paths; they illuminate the close connection between growth models and self-avoiding paths in random environments. In addition to their potential practical value, our algorithms serve to classify these growth models as less complex than other growth models, such as diffusion-limited aggregation, for which fast parallel algorithms probably do not exist.
description: 20 pages, latex, submitted to J. Stat. Phys., UNH-TR94-05
Труды 57-й научной конференции МФТИ
Creators: name: МФТИ
Publisher: name: Zenodo
Year: 2020
Subjects: МФТИ

description: Труды 57-й научной конференции МФТИ с международным участием, посвященной 120-летию со дня рождения П. Л. Капицы
 «Актуальные проблемы фундаментальных и прикладных наук в области физики»
 24–29 ноября 2014 года В архиве содержатся тезисы работ, представленных в виде докладов на конференции студентами, аспирантами и преподавателями кафедр различных факультетов МФТИ.
Translated article: Wenn Geschlechtsverkehr nicht möglich ist: Vorstellung eines internetbasierten Behandlungsprogramms für Genito-Pelvine Schmerz-Penetrationsstörung mit Falldarstellung
Creators: name: Zarski, A.-C.
name: Berking, M.
name: Hannig, W.
name: Ebert, D.D.
Publisher: name: Karger Publishers
Year: 2018
Subjects: Medicine

description: Hintergrund: Schwierigkeiten, Geschlechtsverkehr zu haben trotz bestehenden Wunsches, stellen für Frauen mit Genito-Pelviner Schmerz-Penetrationsstörung (GPSPS) eine große Belastung dar. Die Verfügbarkeit spezifischer Therapieangebote für sexuelle Funktionsstörungen bei Frauen ist begrenzt und existierende Therapiemöglichkeiten werden oftmals aus Schamgefühlen nicht in Anspruch genommen. Internetbasierte Behandlungsansätze können einen niedrigschwelligen, anonymen, zeit- und ortsunabhängigen spezialisierten Therapiezugang ermöglichen. Bislang liegt noch kein wissenschaftlich evaluiertes Programm für die Behandlung von GPSPS vor. Das Ziel der vorliegenden Arbeit ist es deshalb, den Therapieleitfaden eines neu entwickelten internetbasierten, begleiteten Behandlungsprogramms für GPSPS (Paivina-Care) vorzustellen sowie exemplarisch die Akzeptanz und Zufriedenheit und den subjektiven Nutzen anhand eines Fallberichtes darzustellen. Methodik: Das Rational und der Therapieleitfaden des Behandlungsprogramms werden vorgestellt. Die Falldarstellung nach der Case Reporting (CARE)-Leitlinie präsentiert eine Patientin mit erfolgreichem Behandlungsverlauf sowie qualitative und quantitative Erfolgsmaße. Ergebnisse: Die Kasuistik zeigt, dass das kognitiv-verhaltenstherapeutische Programm basierend auf Schmerz- und Sexualtherapie unter Einbezug des Partners die GPSPS bei der vorgestellten Patientin erfolgreich behandeln konnte und mit hoher Therapiezufriedenheit Schmerzen und sexualitätsbezogene Ängste und negative Kognitionen reduzieren sowie Geschlechtsverkehr ermöglichen konnte. Derzeit erfolgt eine randomisiert-kontrollierte Wirksamkeitsuntersuchung an 200 Frauen mit GPSPS. Schlussfolgerung: Das internetbasierte Behandlungsprogramm bietet Frauen mit GPSPS eine flexible Behandlungsmöglichkeit, die sie anonym, zeit- und ortsunabhängig nutzen können.
Papilio daplidice Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Papilionidae
Papilio
Papilio daplidice

description: Papilio daplidice [spec. nov.]
P. D. alis integris rotundatis albis margine fuscis, subtus luteo-griseis albo maculatis.
Habitat in Europa australi & Africa.
Statura P. Napi. Alae apicibus primorum imprimis nigrae cum macula una alterave obsolete fusca; omnes subtus venis dilatatis luteo griseis albo maculatae; in Mare alae posticae supra albae immaculatae.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 468, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT
Creators: name: Kohlfaerber, Tabea
name: Ding, Shujun
name: Rahmanzadeh, Ramtin
name: Jüngst, Thomas
name: Groll, Jürgen
name: Schulz-Hildebrandt, Hinnerk
name: Hüttmann, Gereon
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2019

description: Optical coherence tomography is a non-invasive and label-free imaging modality based on the detection of backscattered light in samples. As microscopic OCT (mOCT) combines high axial and lateral resolution, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 1 (2019): Trans. AMMM
Additional file 6 of Cross-sectional study for the clinical application of extracorporeal membrane oxygenation in Mainland China, 2018
Creators: name: Cheng, Wei
name: Ma, Xu-Dong
name: Su, Long-Xiang
name: He, Huai-Wu
name: Wang, Lu
name: Tang, Bo
name: Du, Wei
name: Zhou, Yuan-kai
name: Wang, Hao
name: Cui, Na
name: Long, Yun
name: Liu, Da-Wei
name: Guo, Yan-Hong
name: Wang, Ye
name: Shan, Guang-Liang
name: Zhou, Xiang
name: Zhang, Shu-Yang
name: Zhao, Yu-Pei
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 6: eTable 6 The number and proportion of patients treated with prone position in the provinces with more than 25 cases of VV ECMO.
OVERVIIEW OF FUTURE IINTERNET ARCHIITECTURE PROJJECTS AND PROTOCOLS AND APPLIICATIIONS
Creators: name: HEZAM, TAMEEM
Publisher: name: figshare
Year: 2021
Subjects: subject: Computer Software
subject: FOS: Computer and information sciences
subject: Computer Engineering
subject: 100503 Computer Communications Networks
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: Applied Computer Science

description: The number of gadgets linked to the internet has expanded dramatically in recent years. Thesegadgets can interact with the outside world and with people via a variety of sensors that can offera massive amount of data by perceiving reality through the digitization of some key aspects. All ofthis information is then exchanged across the network with other devices, apps, and infrastructures.The Internet of Things (IoT) paradigm is based on this dynamic and ever-changing world. CountlessIoT-based applications have been developed to date; consider Smart Cities, smart highways, andsmart industries. The existing structures, technologies, protocols, and applications that describe theparadigm are examined in this report.also ,In many ways, the modern Internet, which was created more than 50 years ago, is confrontingunprecedented problems, particularly in the commercial context. Incremental adjustments throughad-hoc patches are difficult to meet the rising expectations for security, mobility, content distribution,and so on. These issues are predicted to be addressed by new clean-slate architecture designs basedon new design concepts. In this study, I look into some of the most important study areas in the fieldof future Internet architecture. Several ongoing research projects from China, the United States, theEuropean Union, Japan, and other countries are discussed. We want to get a sense of how far researchon future Internet architecture has progressed. In addition, I will discuss the MobilityFirst FutureInternet Architecture Project.
Bayeslands: A Bayesian inference approach for parameter uncertainty quantification in Badlands
Creators: name: Chandra, Rohitash
name: Azam, Danial
name: Müller, R. Dietmar
name: Salles, Tristan
name: Cripps, Sally
Publisher: name: arXiv
Year: 2018
Subjects: subject: Geophysics (physics.geo-ph)
subject: Artificial Intelligence (cs.AI)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Bayesian inference provides a rigorous methodology for estimation and uncertainty quantification of parameters in geophysical forward models. Badlands (basin and landscape dynamics model) is a landscape evolution model that simulates topography development at various space and time scales. Badlands consists of a number of geophysical parameters that needs estimation with appropriate uncertainty quantification; given the observed present-day ground truth such as surface topography and the stratigraphy of sediment deposition through time. The inference of unknown parameters is challenging due to the scarcity of data, sensitivity of the parameter setting and complexity of the Badlands model. In this paper, we take a Bayesian approach to provide inference using Markov chain Monte Carlo sampling (MCMC). We present \textit{Bayeslands}; a Bayesian framework for Badlands that fuses information obtained from complex forward models with observational data and prior knowledge. As a proof-of-concept, we consider a synthetic and real-world topography with two parameters for Bayeslands inference, namely precipitation and erodibility. The results of the experiments show that Bayeslands yields a promising distribution of the parameters. Moreover, we demonstrate the challenge in sampling irregular and multi-modal posterior distributions using a likelihood surface that has a range of sub-optimal modes.
Relaxation of Wobbling Asteroids and Comets. Theoretical Problems. Perspectives of Experimental Observation
Creators: name: Efroimsky, Michael
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: Dynamical Systems (math.DS)
subject: Chaotic Dynamics (nlin.CD)
subject: Geophysics (physics.geo-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: A body dissipates energy when it freely rotates about any axis different from principal. This entails relaxation, i.e., decrease of the rotational energy, with the angular momentum preserved. The spin about the major-inertia axis corresponds to the minimal kinetic energy, for a fixed angular momentum. Thence one may expect comets and asteroids (as well as spacecraft or cosmic-dust granules) stay in this, so-called principal, state of rotation, unless they are forced out of this state by a collision, or a tidal interaction, or cometary jetting, or by whatever other reason. As is well known, comet P/Halley, asteroid 4179 Toutatis, and some other small bodies exhibit very complex rotational motions attributed to these objects being in non-principal states of spin. Most probably, the asteroid and cometary wobble is quite a generic phenomenon. The theory of wobble with internal dissipation has not been fully developed as yet. In this article we demonstrate that in some spin states the effectiveness of the inelastic-dissipation process is several orders of magnitude higher than believed previously, and can be measured, by the presently available observational instruments, within approximately a year span. We also show that in some other spin states both the precession and precession-relaxation processes slow down considerably. (We call it near-separatrix lingering effect.) Such spin states may evolve so slowly that they can mimic the principal-rotation state.
description: 2 figures
Tame multiplicity and conductor for local Galois representations
Creators: name: Bushnell, Colin J.
name: Henniart, Guy
Publisher: name: arXiv
Year: 2018
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11S37, 11S15, 22E50

description: Let $F$ be a non-Archimedean locally compact field of residual characteristic $p$. Let $σ$ be an irreducible smooth representation of the absolute Weil group $\Cal W_F$ of $F$ and $\sw(σ)$ the Swan exponent of $σ$. Assume $\sw(σ) \ge1$. Let $\Cal I_F$ be the inertia subgroup of $\Cal W_F$ and $\Cal P_F$ the wild inertia subgroup. There is an essentially unique, finite, cyclic group $\varSigma$, of order prime to $p$, so that $σ(\Cal I_F) = σ(\Cal P_F)\varSigma$. In response to a query of Mark Reeder, we show that the multiplicity in $σ$ of any character of $\varSigma$ is bounded by $\sw(σ)$.
description: Revised version with further detail
Bruker Micro-CT User Meeting 2016 Abstract book
Creators: name: Bruker
Publisher: name: Zenodo
Year: 2020
Subjects: microCT

description: The Abstract Book from the "Bruker Micro-CT User Meeting 2016 Abstract book".
description: This file was previously available at http://bruker-microct.com/company/UM2016/AbstractBook2016.pdf .
Translated artikel: Wenn Geschlechtsverkehr nicht möglich ist: Vorstellung eines internetbasierten Behandlungsprogramms für Genito-Pelvine Schmerz-Penetrationsstörung mit Falldarstellung
Creators: name: Zarski, A.-C.
name: Berking, M.
name: Hannig, W.
name: Ebert, D.D.
Publisher: name: Karger Publishers
Year: 2018
Subjects: Medicine

description: Hintergrund: Schwierigkeiten, Geschlechtsverkehr zu haben trotz bestehenden Wunsches, stellen für Frauen mit Genito-Pelviner Schmerz-Penetrationsstörung (GPSPS) eine große Belastung dar. Die Verfügbarkeit spezifischer Therapieangebote für sexuelle Funktionsstörungen bei Frauen ist begrenzt und existierende Therapiemöglichkeiten werden oftmals aus Schamgefühlen nicht in Anspruch genommen. Internetbasierte Behandlungsansätze können einen niedrigschwelligen, anonymen, zeit- und ortsunabhängigen spezialisierten Therapiezugang ermöglichen. Bislang liegt noch kein wissenschaftlich evaluiertes Programm für die Behandlung von GPSPS vor. Das Ziel der vorliegenden Arbeit ist es deshalb, den Therapieleitfaden eines neu entwickelten internetbasierten, begleiteten Behandlungsprogramms für GPSPS (Paivina-Care) vorzustellen sowie exemplarisch die Akzeptanz und Zufriedenheit und den subjektiven Nutzen anhand eines Fallberichtes darzustellen. Methodik: Das Rational und der Therapieleitfaden des Behandlungsprogramms werden vorgestellt. Die Falldarstellung nach der Case Reporting (CARE)-Leitlinie präsentiert eine Patientin mit erfolgreichem Behandlungsverlauf sowie qualitative und quantitative Erfolgsmaße. Ergebnisse: Die Kasuistik zeigt, dass das kognitiv-verhaltenstherapeutische Programm basierend auf Schmerz- und Sexualtherapie unter Einbezug des Partners die GPSPS bei der vorgestellten Patientin erfolgreich behandeln konnte und mit hoher Therapiezufriedenheit Schmerzen und sexualitätsbezogene Ängste und negative Kognitionen reduzieren sowie Geschlechtsverkehr ermöglichen konnte. Derzeit erfolgt eine randomisiert-kontrollierte Wirksamkeitsuntersuchung an 200 Frauen mit GPSPS. Schlussfolgerung: Das internetbasierte Behandlungsprogramm bietet Frauen mit GPSPS eine flexible Behandlungsmöglichkeit, die sie anonym, zeit- und ortsunabhängig nutzen können.
Negative 4-Probe Conductances of Mesoscopic Superconducting Wires
Creators: name: Robinson, SJ
name: Lambert, CJ
name: Jeffery, M
Publisher: name: arXiv
Year: 1994
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We analyze the longitudinal 4-probe conductance of mesoscopic normal and superconducting wires and predict that in the superconducting case, large negative values can arise for both the weakly disordered and localized regimes. This contrasts sharply with the behaviour of the longitudinal 4-probe conductance of normal wires, which in the localized limit is always exponentially small and positive.
description: Latex, 3 figures available on request to pya055@cent1.lancs.ac.uk (Simon Robinson)
Anisotropic exciton transport in transition-metal dichalcogenides
Creators: name: Ghazaryan, Areg
name: Hafezi, Mohammad
name: Ghaemi, Pouyan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Due to the Coulomb interaction exciton eignestates in monolayer transitional metal dichalcogenides are coherent superposition of two valleys. The exciton band which couples to the transverse electric mode of light has parabolic dispersion for the center of mass momentum, whereas the one which couples to the transverse magnetic mode has both parabolic and linear components. In this work we present an experimental proposal to observe the signatures of linear component of the dispersion. In particular, it is demonstrated that by pumping the system with linearly polarized light the exciton transport is anisotropic compared to circularly polarized pump. We show that the results persist for moderate level of disorder present in realistic systems. Finally, we demonstrate that similar effects can be obtained for positively detuned exciton-polaritons, in less stringent experimental requirements compared to bare exciton case.
description: 7 pages, 5 figures
Feasibility of 3D printing for customized radiotherapeutic models to be used in superficial skin cancer therapy
Creators: name: Pashazadeh, Ali
name: Castro, Nathan
name: Morganti, Elena
name: Wille, Marie-Luise
name: Boese, Axel
name: Hutmacher, Dietmar
name: Friebe, Michael
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2019

description: Skin brachytherapy is an effective treatment for patients with skin cancers. It is based upon the use of an applicator containing a gamma-emitting source located near the tumor. For superficial and shallow skin tumors close to sensitive structures, we propose a new brachytherapy method using 3D printing technology employing beta-emitting isotopes. The beta-emitting patches would allow for directed, effective and controlled dose delivery to the skin tumors, thus mitigating exposure to sensitive structures.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 1 (2019): Trans. AMMM
title: Comptes de la Chartreuse de Champmol pour l'année 1402 - Archives départementales de la Côte-d'Or, B 11673 0002
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: LaMOP
subject: Laboratoire de médiévistique occidentale de Paris

description: Comptes de la Chartreuse de Champmol pour l’année 1402 [nouveau style]
Document transcrit dans le cadre des ateliers de paléographie du Chancelier Rolin des Archives départements des Côtes d’Or
Page : 2/2
description: Source: https://archives.cotedor.fr/v2/site/AD21/web/media/04_apprendre/02_ateliers_chancelier_rolin/paleographie/debutants/2015_2016/doc_03/document_03.pdf
description: Source: https://www.nakala.fr/10.34847/nkl.5ee67hf3
description: Comptes de la Chartreuse de Champmol pour l'année 1402 - Archives départementales de la Côte-d'Or, B 11673 0002
PROXIMITY RING FED MULTIBAND PRINTED MONOPOLE FRACTAL ANTENNA
Creators: name: Ofernandez, Ricard
Publisher: name: figshare
Year: 2018
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Small antennas satisfying bandwidth requirements in wideband, broadband and multichannel communication systems are of wide interest among researchers. This paper investigates the resonant behaviour of proximity coupled circular fractal planar monopole against circular fractal planar monopole without proximity coupling. The antennas are fed using microstripline and coplanar waveguide technique. These antennas are designed and printed on low cost FR4 substrate ( height h=1.56mm and εr =4.3) of size 110 mm by 115 mm with circular patch radius of 40 mm. The planar fractal monopole shows multiband characteristics under different configurations of feed. The monopole can be used for various compact applications in 482 MHz to 4 GHz band.
Universal Statistics of Transport in Disordered Conductors
Creators: name: Lee, Hyunwoo
name: Yakovetz, A. Yu.
name: Levitov, L. S.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: In low temperature limit, we study electron counting statistics of a disordered conductor. We derive an expression for the distribution of charge transmitted over a finite time interval by using a result from the random matrix theory of quasi one dimensional disordered conductors. In the metallic regime, we find that the peak of the distribution is Gaussian and shows negligible sample to sample variations. We also find that the tails of the distribution are neither Gaussian nor Poisson and exhibit strong sample to sample variations.
description: 11 pages, REVTEX3.0, MIT-CMT-HL9409
Permeation-enhancing effects and mechanisms of O-acylterpineol on isosorbide dinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images
Creators: name: Li, Yan
name: Wang, Chunyan
name: Wang, Jian
name: Chu, Tianzhe
name: Zhao, Linlin
name: Zhao, Ligang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: The present study aimed to evaluate the penetration activity of O-acylterpineol derivatives both in vitro and in vivo, and to investigate the enhancing mechanism of O-acylterpineol derivatives which were synthesized by α-terpineol and fatty acid. The promoting activities on the isosorbide dinitrate patch were tested across full thickness rabbit skin both in vitro and in vivo. In order to elucidate the permeation mechanism, attenuated total reflection Fourier transform infrared spectroscopy, molecular modeling, and confocal laser scanning microscopy were introduced to investigate the regulation of enhancers in the skin permeability and biophysical properties. With in vitro cytotoxicity test and in vivo erythema model, the skin irritation of enhancers was also evaluated. Permeation studies showed 2-(4-methylcyclohex-3-en-l-yl) propan-2-yl tetradecanoate produced the obvious enhancement activity for ISDN both in vitro and in vivo from patches. These results were supported by ATR-FTIR, molecular modeling, and CLSM studies which revealed that O-acylterpineol could decrease the order of the alkyl chains in the skin lipids. Additionally, it was found that TER-C14 produced a relatively low skin irritation, compared with the TER which was assumed to be a safe compound. The present research suggested that some newly designed acylterpineol derivatives are shown to be suitable permeation enhancers for transdermal drug delivery, and the chain length of C14 seem to be safe and more favorable for the penetration of ISDN from DIA patches.
Papilio cardamines Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Papilionidae
Papilio
Papilio cardamines

description: Papilio cardamines [spec. nov.]
P. D. alis integerrimis rotundatis albis: primoribus medio fulvis; posticis subtus viridi nebulosis.
Fn. svec. 801. P. Aurora.
Valent. herb. t. 183.
Habitat in Cardamine, Brassica campestri, Thlaspi.
Sexus alter caret macula fulva in alis primoribus.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on pages 468-469, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Search for an axion-induced oscillating electric dipole moment for electrons using atomic magnetometers
Creators: name: Chu, P. -H.
name: Kim, Y. J.
name: Savukov, I.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We propose an experimental search for an axion-induced oscillating electric dipole moment (OEDM) for electrons using state-of-the-art alkali vapor-cell atomic magnetometers. The axion is a hypothesized new fundamental particle which can resolve the strong charge-parity problem and be a prominent dark matter candidate. This experiment utilizes an atomic magnetometer as both a source of optically polarized electron spins and a magnetic-field sensor. The interaction of the axion field, oscillating at a frequency equal to the axion mass, with an electron spin induces a sizable OEDM of the electron at the same frequency as the axion field. When the alkali vapor is subjected to an electric field and a magnetic field, the electron OEDM interacts with the electric field, resulting in an electron spin precession at the spin's Larmor frequency in the magnetic field. The resulting precession signal can be sensitively detected with a probe laser beam of the atomic magnetometer. We estimate that the experiment is sensitive to the axion-photon interaction in ultralight axion masses from $10^{-15}$ to $10^{-10}$~eV. It is able to improve the current experimental limit up to 5 orders of magnitude, exploring new axion parameter spaces.
Additional file 1: of A role for actomyosin contractility in Notch signaling
Creators: name: Hunter, Ginger
name: He, Li
name: Perrimon, Norbert
name: Charras, Guillaume
name: Giniger, Edward
name: Baum, Buzz
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Figure S1. Contribution of Myosin II activity to Notch response. (A) RNAi against an activator of Myosin II activity, Rho kinase (ROK) in signal sending cells alone does not disrupt protrusion morphology. (B-C) Decreased ROK activity in signal sending cells alone (via neur-GAL4) leads to decreased Notch response in both (B) adjacent and (C) distant wildtype neighboring cells (non-linear regression, comparison of fit, Prism). (D) Decreased ROK activity in all cells (via pnr-GAL4) does not affect the rate of signaling between adjacent cells, but does decrease the total signal (1 N control vs RNAi elevations, p < 0.001 by linear regression). (E) The rate of Notch response in distant neighbors is significantly affected by ROK RNAi expression (linear regression, Prism). (F) S2R+ cells expressing synNotch in the absence of ligand expressing cells and cultured in the presence of Y27632 and/or Dynasore do not exhibit changes in their expression of synNotch in response to drug treatment. (G) Acute inhibition of ROK does not significantly alter the basal synNotch activity measured in S2R+ cells expressing synNotch in the absence of ligand expressing cells. (H) Basal synNotch activity is affected by transfection of zip and spaghetti squash siRNA, but not by acute treatment with Dynasore. However, because fold changes of synNotch activity in the presence of GFP-ligand is calculated based on each treatment respectively, the relative fold changes should still primarily reflect the efficiency of synNotch cleavage under different conditions. (PDF 1657 kb)
Supplementary Material for: EGFR T790M Mutation in TKI-Naïve Clinical Samples: Frequency, Tissue Mosaicism, Predictive Value and Awareness on Artifacts
Creators: name: Lavdovskaia, E.D.
name: Iyevleva, A.G.
name: Sokolenko, A.P.
name: Mitiushkina, N.V.
name: Preobrazhenskaya, E.V.
name: Tiurin, V.I.
name: Ivantsov, A.O.
name: Bizin, I.V.
name: Stelmakh, L.V.
name: Moiseyenko, F.V.
name: Karaseva, N.A.
name: Orlov, S.V.
name: Moiseyenko, V.M.
name: Korzhenevskaya, M.A.
name: Zaitsev, I.A.
name: Kozak, A.R.
name: Chistyakov, I.V.
name: Akopov, A.L.
name: Volkov, N.M.
name: Togo, A.V.
name: Imyanitov, E.N.
Publisher: name: Karger Publishers
Year: 2018
Subjects: Medicine

description: Background: This study evaluated the distribution of epidermal growth factor receptor (EGFR) T790M mutations in treatment-naïve tumor and normal samples obtained from cancer patients. Methods: We utilized allele-specific PCR (AS-PCR), digital droplet PCR (ddPCR) and next generation sequencing (NGS) to detect EGFR T790M allele in several collections of tumor and normal human tissues. Results: AS-PCR analysis of treatment-naïve tumor samples revealed somatic T790M mutation in 3/394 (1%) non-small cell lung carcinomas (NSCLC) carrying the tyrosine kinase inhibitor (TKI)-sensitizing EGFR mutation, but in none of 334 NSCLC lacking EGFR exon 19 deletions (ex19del) or L858R substitutions and in none of 235 non-lung tumors. Use of highly sensitive and quantitative assays, such as ddPCR and NGS, produced a high number of T790M-specific signals even in presumably T790M-negative DNA specimens. This background noise was evidently higher in degraded DNA isolated from formalin-fixed paraffin-embedded tissues as compared to high molecular weight DNA. A combination of AS-PCR, ddPCR and NGS revealed mosaic EGFR T790M allele in 2/68 (3%) NSCLC treated with the first-generation TKI. Both these tumors produced evident and durable response to gefitinib. Conclusion: Detection of mosaic EGFR T790M mutation in treatment-naïve samples may be compromised by yet unresolved technical issues and may have limited clinical value.
3D printing of hydrogel scaffolds based on poly(ethylene glycol) diacrylate
Creators: name: Klimaschewski, Sven Frank
name: Vehse, Mark
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2019

description: This is a case study for the development of a poly(ethylene glycol) diacrylate-based hydrogel for an additive manufacturing process. By introducing a photoinitiator and an UV absorber into the poly(ethylene glycol) diacrylate a spatially and temporally three-dimensional polymerization takes place. To demonstrate the possible printing resolution a scaffold is generated on a modified commercial stereolithography system.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 1 (2019): Trans. AMMM
Table S1 from Multiplex core–periphery organization of the human connectome
Creators: name: Battiston, Federico
name: Guillon, Jeremy
name: Chavez, Mario
name: Latora, Vito
name: Fallani, Fabrizio De Vico
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: What is the core of the human brain is a fundamental question that has been mainly addressed by studying the anatomical connections between differently specialized areas, thus neglecting the possible contributions from their functional interactions. While many methods are available to identify the core of a network when connections between nodes are all of the same type, a principled approach to define the core when multiple types of connectivity are allowed is still lacking. Here, we introduce a general framework to define and extract the core–periphery structure of multi-layer networks by explicitly taking into account the connectivity patterns at each layer. We first validate our algorithm on synthetic networks of different size and density, and with tunable overlap between the cores at different layers. We then use our method to merge information from structural and functional brain networks, obtaining in this way an integrated description of the core of the human connectome. Results confirm the role of the main known cortical and subcortical hubs, but also suggest the presence of new areas in the sensori-motor cortex that are crucial for the intrinsic brain functioning. Taken together these findings provide fresh evidence on a fundamental question in modern neuroscience and offer new opportunities to explore the mesoscale properties of multimodal brain networks.
Characterization of Gram matrices of multimode coherent states
Creators: name: Marwah, Ashutosh S
name: Lütkenhaus, Norbert
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum communication protocols are typically formulated in terms of abstract qudit states and operations, leaving the question of an experimental realization open. Direct translation of these protocols, say into single photons with some d-dimensional degree of freedom, are typically challenging to realize. Multi-mode coherent states, on the other hand, can be easily generated experimentally. Reformulation of protocols in terms of these states has been a successful strategy for implementation of quantum protocols. Quantum key distribution and the quantum fingerprinting protocol have both followed this route. In this paper, we characterize the Gram matrices of multi-mode coherent states in an attempt to understand the class of communication protocols, which can be implemented using these states. As a side product, we are able to use this characterization to show that the Hadamard exponential of a Euclidean distance matrix is positive semidefinite. We also derive the closure of the Gram matrices, which can be implemented in this way, so that we also characterize those matrices, which can be approximated arbitrarily well using multi-mode coherent states. Using this we show that Gram matrices of mutually unbiased bases cannot be approximated arbitrarily well using multi-mode coherent states.
description: For the convenience of the reader, this version (v3) incorporates the changes made in the erratum into the paper. Two new examples are added. For the published version of the article see v2
Looking at the Haldane Conjecture from a Grouptheoretical Point of View
Creators: name: Mütter, K. -H.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: Based on the Lieb-Schultz-Mattis construction we present a five parameter family of Spin-1 Hamiltonians with degenerate groundstate. Starting from the critical $SU(3)$ symmetric Hamiltonian, we look for those perturbations of the $SU(3)$ symmetry, which leave the groundstate degenerate. We also discuss the spin-3/2 $SU(4)$-case.
description: 9 pages RevTex 3.0
Additional file 6: of A role for actomyosin contractility in Notch signaling
Creators: name: Hunter, Ginger
name: He, Li
name: Perrimon, Norbert
name: Charras, Guillaume
name: Giniger, Edward
name: Baum, Buzz
Publisher: name: figshare
Year: 2019
Subjects: Biophysics
Physical Sciences not elsewhere classified
Cell Biology
Molecular Biology
Pharmacology
Information Systems not elsewhere classified
Developmental Biology

description: Figure S4. Data supporting main Fig. 6. (A) additional panels of the same genotype and treatment as in Fig. 6B-B”. Filamentous actin in red, phosphorylated myosin regulatory light chain in greyscale. Basal projection images are a maximum intensity projection over 2–4 μm to visualize protrusions. Single slice images are a single z-plane with in the projection images that show the pMRLC puncta. (B) Cartoon to clarify the genetics of the GRASP experiment in Fig. 6C-C”. (PDF 3497 kb)
Elastic Co--Tunneling in a 1D Quantum Hole Approach
Creators: name: Muller, Heinz-Olaf
name: Hadicke, Andreas
name: Krech, Wolfram
Publisher: name: arXiv
Year: 1994
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: The influence of the phases of tunneling matrix elements on the rate of the elastic co--tunneling at an ultrasmall normal--conducting double--junction is studied in a simple quantum--hole approach at zero temperature. The results are compared with experimental data.
description: 8 pages, REVTeX v3.0
Supplementary Materials from The atypically high modulus of pollen exine
Creators: name: Zihao Qu
name: J. Carson Meredith
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biophysics
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: This file contains expanded experimental details, morphology and modulus maps, a schematic of pollen and pollenkitt, and modulus and force-distance data for both AFM probes.
title: AN, Registre des écrous du Châtelet, Y5266, f. p1000831
Creators: name: Claustre, Julie
name: Nationales, Archives
name: Archives Nationales
name: Claustre, Julie
name: ArchivesNationales/J.CLAUSTRE/H.REGAZZI/2020
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Châtelet
subject: registre
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Registre des écrous du Châtelet, Archives Nationales, Y5266. Numérisation en mode image.
description: Bibliographic citation: Archives Nationales, Registre des écrous du Châtelet, Y5266, f. p1000831
Text S1 from Multiplex core–periphery organization of the human connectome
Creators: name: Battiston, Federico
name: Guillon, Jeremy
name: Chavez, Mario
name: Latora, Vito
name: Fallani, Fabrizio De Vico
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: What is the core of the human brain is a fundamental question that has been mainly addressed by studying the anatomical connections between differently specialized areas, thus neglecting the possible contributions from their functional interactions. While many methods are available to identify the core of a network when connections between nodes are all of the same type, a principled approach to define the core when multiple types of connectivity are allowed is still lacking. Here, we introduce a general framework to define and extract the core–periphery structure of multi-layer networks by explicitly taking into account the connectivity patterns at each layer. We first validate our algorithm on synthetic networks of different size and density, and with tunable overlap between the cores at different layers. We then use our method to merge information from structural and functional brain networks, obtaining in this way an integrated description of the core of the human connectome. Results confirm the role of the main known cortical and subcortical hubs, but also suggest the presence of new areas in the sensori-motor cortex that are crucial for the intrinsic brain functioning. Taken together these findings provide fresh evidence on a fundamental question in modern neuroscience and offer new opportunities to explore the mesoscale properties of multimodal brain networks.
Additional file 2: of A role for actomyosin contractility in Notch signaling
Creators: name: Hunter, Ginger
name: He, Li
name: Perrimon, Norbert
name: Charras, Guillaume
name: Giniger, Edward
name: Baum, Buzz
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology

description: Figure S2. Localization of Notch and Delta with decreased Myosin II activity. In tissues expressing control (LifeActRuby) or sqhAA constructs in SOP cells (tubGAL80ts; neur-GAL4, UAS-GMCA) we observe no differences in (A) Notch localization or (B) Delta localization at a single apical section and basal projection (over 2 μm). Scale bars, 10 μm and 5 μm (sqhAA anti-Delta panels). (PDF 4856 kb)
Utilization of cryogenic temperatures to reduce line width variability in 3D bioprinted hydrogel lattices
Creators: name: Warburton, Linnea
name: Liu, Catherine
name: Dharmadhikari, Kunal
name: Vemulakonda, Pavan
name: Cheema, Yahya
name: Kewelramani, Neal
name: Sidelnikov, Danielle
name: Aroom, Kevin
name: Schultheis, Lester
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2019

description: The 3D bioprinting of acellular hydrogel scaffolds holds enormous potential for wound healing and the regeneration of tissue. The precision of hydrogel scaffolds is limited by the diffusion and fusion of soft hydrogels during the printing process. The use of cryogenic temperatures may reduce the unequal diffusion of 3D printed hydrogel and thus protect pore morphology. Our results suggest that hydrogel lattices printed at cryogenic temperatures display less variation in line width along the length of the printed segments as well as sharper outer corners.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 1 (2019): Trans. AMMM
«Argilla Studium 2015» и «ГЛИНЫ-2015» - программа и материалы
Creators: name: ИГЕМ РАН
Publisher: name: Zenodo
Year: 2015

description: Материалы Третьего Российского Совещания по глинам и глинистым минералам
«ГЛИНЫ-2015», Москва, ИГЕМ РАН, 2015, 148 стр. с илл.

Материалы Четвертой Российской Школы по глинистым минералам
«Argilla Studium-2015» - Москва, ИГЕМ РАН, 2015, 58 стр. с илл.

 

Издание представляет собой материалы докладов по различным аспектам изучения глин и глинистых минералов. 

 

Подготовка издания:
В.В. Крупская.
RankDCG: Rank-Ordering Evaluation Measure
Creators: name: Katerenchuk, Denys
name: Rosenberg, Andrew
Publisher: name: arXiv
Year: 2018
Subjects: subject: Information Retrieval (cs.IR)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Ranking is used for a wide array of problems, most notably information retrieval (search). There are a number of popular approaches to the evaluation of ranking such as Kendall's $τ$, Average Precision, and nDCG. When dealing with problems such as user ranking or recommendation systems, all these measures suffer from various problems, including an inability to deal with elements of the same rank, inconsistent and ambiguous lower bound scores, and an inappropriate cost function. We propose a new measure, rankDCG, that addresses these problems. This is a modification of the popular nDCG algorithm. We provide a number of criteria for any effective ranking algorithm and show that only rankDCG satisfies all of them. Results are presented on constructed and real data sets. We release a publicly available rankDCG evaluation package.
PMMA and PVP based polymers for stereolitho-graphic manufacture of tailored drug release
Creators: name: Wulf, Katharina
name: Riess, Celine
name: Rekowska, Natalia Dominika
name: Eickner, Thomas
name: Seitz, Hermann
name: Grabow, Niels
name: Teske, Michael
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2019

description: Poly(methyl methacrylate) (PMMA) and polyvinylpyrrolidone (PVP) based polymers were tested for stereolithographic manufacture of tailored drug release systems. We adjusted the drug release by addition of the photopolymers pentaerythritoltriacrylate (PETA) and poly(ethylene glycol) diacrylate (PEGDA). As model drug high molecular bovine serum albumin labeled with fluorescein (BSA-FITC) was used. Changes in swelling behavior and drug release were observed. Higher concentrations of the crosslinker reduced the release and the swelling of PVP. PEGDA had a retarding effect on PVP only, whereas PETA affected both polymers. The stereolithographic designed drug depots could be applied in wound healings and dentistry.
description: Transactions on Additive Manufacturing Meets Medicine, Vol 1 (2019): Trans. AMMM
Nesting Mechanism for d-symmetry Superconductors
Creators: name: Ruvalds, J.
name: Rieck, C. T.
name: Tewari, S.
name: Thoma, J.
name: Virosztek, A.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: A nested Fermi surface with nearly parallel orbit segments is found to yield a singlet d-wave superconducting state at high temperatures for a restricted range of the on-site Coulomb repulsion that avoids the competing spin density wave instability. The computed superconducting transition temperature drops dramatically as the nesting vector is decreased, in accord with recent photo-emission data on the Bi2212 and Bi2201 cuprates.
description: 9 pages, 4 figures (available upon request), ReVTeX
Klimaschutz und Nachhaltigkeit: Ein Wandel muss her!
Creators: name: Gingrich, Simone
Publisher: name: Zenodo
Year: 2019

description: Klimaschutz und Nachhaltigkeit: Ein Wandel muss her!

Österreich hat sich wie alle UN-Mitgliedstaaten in der Agenda 2030 verpflichtet, auf die Erreichung der 17 UN-Nachhaltigkeitsziele hinzuarbeiten. Ein Blick auf die Energiegeschichte zeigt, wie groß der Wandel sein muss, der dafür notwendig ist