cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors
Creators: name: Xie, Lan
name: Jiang, Shibo
name: Qin, Bingjie
name: Wang, Xiaofeng
name: Lee, Kuo-Hsiung
name: Chen, Chin Ho
name: Tian, Xingtao
name: Wu, Zhiyuan
name: Morris-Natschke, Susan L.
name: Lu, Hong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Based on the structures and activities of our previously identified non-nucleoside reverse transcriptase inhibitors (NNRTIs), we designed and synthesized two sets of derivatives, diarylpyridines (A) and diarylanilines (B), and tested their anti-HIV-1 activity against infection by HIV-1 NL4-3 and IIIB in TZM-bl and MT-2 cells, respectively. The results showed that most compounds exhibited potent anti-HIV-1 activity with low nanomolar EC50 values, and some of them, such as 13m, 14c, and 14e, displayed high potency with subnanomolar EC50 values, which were more potent than etravirine (TMC125, 1) in the same assays. Notably, these compounds were also highly effective against infection by multi-RTI-resistant strains, suggesting a high potential to further develop these compounds as a novel class of NNRTIs with improved antiviral efficacy and resistance profile.
title: REACT – Clinical Utility of a Free-Breathing, Non-Gated, Non-Contrast 3D Magnetic Resonance Angiography Technique
Creators: name: Chong, Le Roy
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Arteriovenous malformations
subject: Diagnostic procedure
subject: MR-Angiography
subject: Vascular
subject: Cardiovascular system

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - Describe REACT – a novel flow–independent non-contrast 3D MRA pulse sequence - Discuss differences between REACT and other non-contrast MRA techniques - Discuss advantages and limitations of REACT - Present clinical utility of REACT through...
title: What radiologist should know about ultrasound diagnosis of inguinal pathology in pediatrics
Creators: name: CASTRO GARCIA, ALEINY
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Image registration
subject: Education
subject: Ultrasound
subject: Abdomen
subject: Paediatric

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To know the anatomy of the inguinal canal and its embryological origin. To know the different pathologies that can involve the inguinal canal in pediatrics. To review some practical aspects about ultrasonography of the inguinal...
The Ĝ Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. I. Background and Justification
Creators: name: Wright, J. T.
name: Mullan, B.
name: Sigurðsson, S.
name: Povich, M. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Popular Physics (physics.pop-ph)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We motivate the Ĝ infrared search for extraterrestrial civilizations with large energy supplies. We discuss some philosophical difficulties of SETI, and how communication SETI circumvents them. We review "Dysonian SETI", the search for artifacts of alien civilizations, and find that it is highly complementary to traditional communication SETI; the two together might succeed where either one, alone, has not. We discuss the argument of Hart (1975) that spacefaring life in the Milky Way should be either galaxy-spanning or non-existent, and examine a portion of his argument that we dub the "monocultural fallacy". We discuss some rebuttals to Hart that invoke sustainability and predict long Galaxy colonization timescales. We find that the maximum Galaxy colonization timescale is actually much shorter than previous work has found ($< 10^9$ yr), and that many "sustainability" counter-arguments to Hart's thesis suffer from the monocultural fallacy. We extend Hart's argument to alien energy supplies, and argue that detectably large energy supplies can plausibly be expected to exist because life has potential for exponential growth until checked by resource or other limitations, and intelligence implies the ability to overcome such limitations. As such, if Hart's thesis is correct then searches for large alien civilizations in other galaxies may be fruitful; if it is incorrect, then searches for civilizations within the Milky Way are more likely to succeed than Hart argued. We review some past Dysonian SETI efforts, and discuss the promise of new mid-infrared surveys, such as that of WISE.
description: 18 pages, accepted for publication in the Astrophysical Journal
Additional file 1 of Brief Educational Workshops in Secondary Schools Trial (BESST): protocol for a school-based cluster randomised controlled trial of open-access psychological workshop programme for 16–18-year-olds
Creators: name: Lisk, Stephen
name: Carter, Ben
name: James, Kirsty
name: Stallard, Paul
name: Deighton, Jessica
name: Yarrum, Jynna
name: Fonagy, Peter
name: Day, Crispin
name: Byford, Sarah
name: Shearer, James
name: Weaver, Timothy
name: Sclare, Irene
name: Evans, Claire
name: Farrelly, Maria
name: Ho, Pin-Cheng
name: Brown, June
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Brief Educational workshops in Secondary Schools Trial (BESST).
title: Left adrenal vein CT anatomy and variants: if you know it, you report it!
Creators: name: Perugin, Giulia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Education and training
subject: Contrast agent-intravenous
subject: Computer Applications-Detection, diagnosis
subject: CT
subject: Veins / Vena cava
subject: Anatomy
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - Review the anatomical variants of the left adrenal vein (LAV) and its embryology. - Show CT findings of LAV anatomical variants. - Identify pitfalls in the depiction of LAV...
Luminosity function and jet structure of Gamma Ray Bursts
Creators: name: Pescalli, A.
name: Ghirlanda, G.
name: Salafia, O. S.
name: Ghisellini, G.
name: Nappo, F.
name: Salvaterra, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The structure of Gamma Ray Burst (GRB) jets impacts on their prompt and afterglow emission properties. The jet of GRBs could be uniform, with constant energy per unit solid angle within the jet aperture, or it could instead be structured, namely with energy and velocity that depend on the angular distance from the axis of the jet. We try to get some insight about the still unknown structure of GRBs by studying their luminosity function. We show that low (1e46-1e48 erg/s) and high (i.e. with L > 1e50 erg/s) luminosity GRBs can be described by a unique luminosity function, which is also consistent with current lower limits in the intermediate luminosity range (1e48-1e50} erg/s). We derive analytical expressions for the luminosity function of GRBs in uniform and structured jet models and compare them with the data. Uniform jets can reproduce the entire luminosity function with reasonable values of the free parameters. A structured jet can also fit adequately the current data, provided that the energy within the jet is relatively strongly structured, i.e. E propto theta^{-k} with k > 4. The classical E propto theta^{-2} structured jet model is excluded by the current data.
description: 11 pages, 2 tables, 7 figures, submitted to MNRAS
title: An analysis of the benefits of the new local modified NICE (National Institute for Health and Care excellence) guidelines of the deep venous thrombo-embolism (DVT) service at Barts Health Trust in an outpatient population – do risk factors matter?
Creators: name: Davendralingam, Natasha
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Acute
subject: Imaging sequences
subject: Ultrasound-Power Doppler
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Vascular
subject: Management
subject: Emergency

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: An initial audit on the outpatient DVT service at Barts Health performed in 2012 (n=526 patients) identified 9 risk factors (Figure 1) that were not included in the NICE guidelines [CG144] (Figure 2 and 3). If excluded, DVTs would have been...
Development, Validation, and Use of Quantitative Structure−Activity Relationship Models of 5-Hydroxytryptamine (2B) Receptor Ligands to Identify Novel Receptor Binders and Putative Valvulopathic Compounds among Common Drugs
Creators: name: Huang, Xi-Ping
name: Tropsha, Alexander
name: Roth, Bryan L.
name: Hajjo, Rima
name: Golbraikh, Alexander
name: Setola, Vincent
name: Grulke, Christopher M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Some antipsychotic drugs are known to cause valvular heart disease by activating serotonin 5-HT2B receptors. We have developed and validated binary classification QSAR models capable of predicting potential 5-HT2B binders. The classification accuracies of the models to discriminate 5-HT2B actives from the inactives were as high as 80% for the external test set. These models were used to screen in silico 59,000 compounds included in the World Drug Index and 122 compounds were predicted as actives with high confidence. Ten of them were tested in radioligand binding assays and nine were found active suggesting a success rate of 90%. All validated binders were then tested in functional assays and one compound was identified as a true 5-HT2B agonist. We suggest that the QSAR models developed in this study could be used as reliable predictors to flag drug candidates that are likely to cause valvulopathy.
HOSPITAL DE LA SANTA CREU I SANT PAU
Creators: name: Santafe, Angie
name: Rojas- Reyes, María
name: Bendersky, Josefina
name: Urrutia, Gerard
name: Santero, Marilina
name: Verdugo, Francisca
name: Jimenez, Elena
name: Vargas, Laura
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: capacity building
subject: Continuos update
subject: Epistemonikos L.OVE Platform
subject: Evidence-based medicine
subject: Evidence Synthesis
subject: Inform Health Decisions
subject: knowledge transfer
subject: Living Evidence

description: Esta carpeta contiene los documentos de los proyectos "Eficacia y Seguridad de Terapias de presión negativa para heridas" y "Efectividad y seguridad de la terapia dirigida en pacientes con cáncer avanzado de ovario: protocolo de revisión panorámica (overview)." como parte del proyecto LE-IHD
title: RCR iRefer and MedCurrent Clinical Decision Support for Appropriate Imaging: The NW London Pilot Project
Creators: name: Remedios, Denis
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Radioprotection / Radiation dose
subject: Management
subject: Computer applications
subject: RIS
subject: PACS
subject: Radiation safety
subject: Audit and standards
subject: Health policy and practice
subject: Workforce
subject: Economics

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Evaluation of innovations for justification and appropriate imaging must consider all stakeholders. Value based healthcare in the UK [1-4] looks for personalised, technical and allocative value. Only through demonstration of value to all parties...
Enhancing adaptive sparse grid approximations and improving refinement strategies using adjoint-based a posteriori error estimates
Creators: name: Jakeman, John D.
name: Wildey, Timothy
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper we present an algorithm for adaptive sparse grid approximations of quantities of interest computed from discretized partial differential equations. We use adjoint-based a posteriori error estimates of the physical discretization error and the interpolation error in the sparse grid to enhance the sparse grid approximation and to drive adaptivity of the sparse grid. Utilizing these error estimates provides significantly more accurate functional values for random samples of the sparse grid approximation. We also demonstrate that alternative refinement strategies based upon a posteriori error estimates can lead to further increases in accuracy in the approximation over traditional hierarchical surplus based strategies. Throughout this paper we also provide and test a framework for balancing the physical discretization error with the stochastic interpolation error of the enhanced sparse grid approximation.
Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
Creators: name: Lee, Kuo-Hsiung
name: Qian, Keduo
name: Huang, Li
name: Xie, Lan
name: Huang, Rong
name: Jiang, Xingkai
name: Lu, Hong
name: Qin, Bingjie
name: Barbault, Florent
name: Chen, Chin-Ho
name: Jiang, Shibo
name: Tian, Xingtao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: By using structure-based drug design and isosteric replacement, diarylaniline and 1,5-diarylbenzene-1,2-diamine derivatives were synthesized and evaluated against wild type HIV-1 and drug-resistant viral strains, resulting in the discovery of diarylaniline derivatives as a distinct class of next-generation HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) agents. The most promising compound 37 showed significant EC50 values of 0.003-0.032 μM against HIV-1 wild-type strains and of 0.005-0.604 μM against several drug-resistant strains. Current results also revealed important structure-activity relationship (SAR) conclusions for diarylanilines and strongly support our hypothesis that an NH2 group on the central benzene ring ortho to the aniline moiety is crucial for interaction with K101 of the NNRTI binding site in HIV-1 RT, likely by forming H-bonds with K101. Furthermore, molecular modeling studies with molecular mechanism/general born surface area (MM/GBSA) technology demonstrated the rationality of our hypothesis.
Additional file 1 of Characteristics and recovery methods of studies falsely excluded during literature screening—a systematic review
Creators: name: Affengruber, Lisa
name: Dobrescu, Andreea
name: Persad, Emma
name: Klerings, Irma
name: Wagner, Gernot
name: Sommer, Isolde
name: Gartlehner, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. PRISMA checklist.
Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds
Creators: name: Wigle, Tim J.
name: Herold, J. Martin
name: Janzen, William P.
name: Frye, Stephen V.
name: Kireev, Dmitri
name: Norris-Drouin, Jacqueline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The Malignant Brain Tumor (MBT) repeat is an important epigenetic-code “reader” and is functionally associated with differentiation, gene silencing and tumor suppression1–3. Small molecule probes of MBT domains should enable a systematic study of MBT-containing proteins, and potentially reveal novel druggable targets. We designed and applied a virtual screening strategy, which identified potential MBT antagonists in a large database of commercially available compounds. A small set of virtual hits was purchased and submitted to experimental testing. Nineteen of the purchased compounds showed a specific dose-dependent protein binding and will provide critical structure-activity information for subsequent lead generation and optimization.
The role of loop stacking in the dynamics of DNA hairpin formation
Creators: name: Mosayebi, Majid
name: Romano, Flavio
name: Ouldridge, Thomas E.
name: Louis, Ard A.
name: Doye, Jonathan P. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We study the dynamics of DNA hairpin formation using oxDNA, a nucleotide-level coarse-grained model of DNA. In particular, we explore the effects of the loop stacking interactions and non-native base pairing on the hairpin closing times. We find a non-monotonic variation of the hairpin closing time with temperature, in agreement with the experimental work of Wallace et al. [Proc. Nat. Acad. Sci. USA 2001, 98, 5584-5589]. The hairpin closing process involves the formation of an initial nucleus of one or two bonds between the stems followed by a rapid zippering of the stem. At high temperatures, typically above the hairpin melting temperature, an effective negative activation enthalpy is observed because the nucleus has a lower enthalpy than the open state. By contrast, at low temperatures, the activation enthalpy becomes positive mainly due to the increasing energetic cost of bending a loop that becomes increasingly highly stacked as the temperature decreases. We show that stacking must be very strong to induce this experimentally observed behavior, and that the existence of just a few weak stacking points along the loop can substantially suppress it. Non-native base pairs are observed to have only a small effect, slightly accelerating hairpin formation.
description: 24 pages, 9 figures
Towards the rational design of new catalysts for organic transformations
Creators: name: Falivene, Laura
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: CHIM/04 CHIMICA INDUSTRIALE
subject: Catalysis
subject: Computational chemistry

description: 2012-2013
description: The main goal of this PhD thesis has been providing a computational support to the development of new or better performing catalysts, leading to the synthesis of new materials. In this context, it is worth remembering that catalysis is a topic of primary relevance in the academy as well as in the industry, due to the enormous impact of catalysis in every day life. In particular, within this PhD project, attention has focused on catalytic systems based on Nheterocyclic carbene (NHC) ligands, which have emerged as useful ligands in the last ten years. In the first part of this thesis, the development of new molecular descriptors for the quantification of steric and electronic effects in transition metal based catalysts has been pursued. The final goal of this approach consists in rationalizing the highly disorganized and chaotic catalytic space, to orientate experimental efforts towards possibly well performing catalysts, and away from the ineffective ones. This would allow to pursue a catalysis by design approach, in alternative to the “trial and error” classical approach. In particular, descriptors based on topographic steric maps have emerged as powerful tools that can be easily used and interpreted by the scientific community. A user friendly web server has been implemented in order to allow the scientific community to build steric maps for the systems of interest. The web server has already achieved great success with a number of visitors all around the world. In the second part of the thesis, attention was focused on developing and rationalizing new catalysts in strict collaboration with experimental groups. The systems investigated represent advanced application of N-heterocyclic carbenes as ligand in Ru-catalyzed olefin metathesis, Pd-catalyzed C-C cross coupling reactions, and as catalysts in the organopolymerization of polar olefins. The detailed mechanistic studies have offered a comprehensive understanding of the whole mechanisms, an achievement almost impossible to achieve with experimental techniques only. The studies described in this work demonstrated that computational techniques can be of enormous value to screen novel catalyst architectures more rapidly, and to obtain insights that could help in the design and experimental synthesis of novel and improved catalysts. [edited by Author]
The Ĝ Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. II. Framework, Strategy, and First Result
Creators: name: Wright, J. T.
name: Griffith, R.
name: Sigurðsson, S.
name: Povich, M. S.
name: Mullan, B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Popular Physics (physics.pop-ph)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We describe the framework and strategy of the Ĝ infrared search for extraterrestrial civilizations with large energy supplies, which will use the wide-field infrared surveys of WISE and Spitzer to search for these civilizations' waste heat. We develop a formalism for translating mid-infrared photometry into quantitative upper limits on extraterrestrial energy supplies. We discuss the likely sources of false positives, how dust can and will contaminate our search, and prospects for distinguishing dust from alien waste heat. We argue that galaxy-spanning civilizations may be easier to distinguish from natural sources than circumstellar civilizations (i.e., Dyson spheres), although Gaia will significantly improve our capability to identify the latter. We present a "zeroth order" null result of our search based on the WISE all-sky catalog: we show, for the first time, that Kardashev Type III civilizations (as Kardashev originally defined them) are very rare in the local universe. More sophisticated searches can extend our methodology to smaller waste heat luminosities, and potentially entirely rule out (or detect) both Kardashev Type III civilizations and new physics that allows for unlimited "free" energy generation.
description: 15 pages, 4 figures, accepted for publication in the Astrophysical Journal
title: Prenatal and postnatal imaging evaluation of Congenital Pulmonary Airway Malformation (CPAM) and Pulmonary Sequestration: what the radiologist needs to know
Creators: name: Giambelluca, Dario
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Cysts
subject: Arteriovenous malformations
subject: Intrauterine diagnosis
subject: MR
subject: CT-High Resolution
subject: Conventional radiography
subject: Respiratory system
subject: Lung
subject: Foetal imaging
subject: Foetus

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Congenital pulmonary airway malformation and pulmonary sequestration represent two entities of the spectrum of bronchopulmonary foregut malformation. These conditions may be detected incidentally on prenatal ultrasound examinations or postnatal...
Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
Creators: name: Hou, Jing
name: Wang, Huanchen
name: Luo, Xuan
name: Ke, Hengming
name: Ye, Mengchun
name: Robinson, Howard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: PDE9 inhibitors have been studied as therapeutics for treatment of cardiovascular diseases, diabetes, and neurodegenerative disorders. To illustrate the inhibitor selectivity, the crystal structures of the PDE9A catalytic domain in complex with the enantiomers of PDE9 inhibitor 1-(2-chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-one ((R)-BAY73-6691 or (S)-BAY73-6691, 1r or 1s) were determined and mutagenesis was performed. The structures showed that the fluoromethyl groups of 1r and 1s had different orientations while the other parts of the inhibitors commonly interacted with PDE9A. These differences may explain the slightly different affinity of 1r (IC50 = 22 nM) and 1s (IC50 = 88 nM). The mutagenesis experiments revealed that contribution of the binding residues to the inhibitor sensitivity varies dramatically, from a few of folds to three orders of magnitude. On the basis of the crystal structures, a hypothesized compound that simulates the recently published PDE9 inhibitors was modeled to provide insight into the inhibitor selectivity.
Τεχνικές εξόρυξης γνώσης με χρήση σημασιολογιών από δεδομένα πλοήγησης χρηστών (web usage log mining) με σκοπό την εξατομίκευση δικτυακών τόπων
Creators: name: Theodoridis, Yiannos
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460502
subject: Data mining and knowledge discovery
classificationCode: 460503
subject: Data models, storage and indexing
classificationCode: 460508
subject: Information retrieval and web search
classificationCode: 460510
subject: Recommender systems

description: Η παρούσα Διπλωματική Εργασία μελετά το θέμα της προσωποποίησης - εξατομίκευσης δικτυακών τόπων.
Αρχικά, παρουσιάζεται μια ανασκόπηση στη σχετική βιβλιογραφία όπου εντοπίζεται πληθώρα αναφορών και λύσεων -ακαδημαϊκών και εμπορικών- για το συγκεκριμένο θέμα. Στις περισσότερες από αυτές τις περιπτώσεις καταβάλλεται προσπάθεια για εξατομίκευση η οποία στηρίζεται σε δεδομένα που συλλέγονται από δηλώσεις ή ενέργειες του χρήστη, άμεσα ή έμμεσα. Όμως, η μελέτη των σχετικών άρθρων δείχνει ότι η μέχρι σήμερα επιτυχία των εγχειρημάτων αξιοποίησης δεδομένων χρήσης του ιστού (web usage data) είναι περιορισμένη. Το βασικό έλλειμμα που διαπιστώνεται είναι το γεγονός ότι η διαχείριση του περιεχομένου ενός δικτυακού τόπου συνήθως γίνεται με μηχανιστικό τρόπο, αποφεύγοντας τόσο την κατανόηση του περιεχομένου του όσο και της δομής του.Ακολούθως, στη Διπλωματική Εργασία γίνεται απόπειρα εξατομίκευσης δικτυακών τόπων με ημιαυτόματο τρόπο χρησιμοποιώντας τα αρχεία καταγραφής χρήσης ιστού ενώ ταυτόχρονα βασίζεται σε σημασιολογικές και εννοιολογικές αναλύσεις του περιεχομένου των δικτυακών τόπων. Με αυτήν τη μέθοδο υλοποιείται ένα εργαλείο που εξατομικεύει τον δικτυακό τόπο προτείνοντας στους χρήστες ιστοσελίδες με παραπλήσιο εννοιολογικό περιεχόμενο. Αυτό γίνεται δημιουργώντας την οντολογία του εκάστοτε δικτυακού τόπου και συνδυάζοντάς τη με τα δεδομένα πλοήγησης των χρηστών.
Il family brand nella comunicazione online: asset o liability?
Creators: name: Santulli, Rosalia
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: SECS-P/08 ECONOMIA E GESTIONE DELLE IMPRESE
subject: Family involument
subject: Branding strategies
subject: Performance

description: 2012 - 2013
description: The research fits in the international debate on the relationship between family involvement and performance, by introducing the branding strategies as moderating variable. Thus, the study approaches the problem by adopting a holistic perspective, encompassing both the structural and strategic aspects. In the first chapter, the thesis presents a systematic review of the literature about family involvement-performance relationship. Moreover, it presents the results of a meta-analysis applied to the empirical studies. In the second chapter, it outlines the issues of brand management in family firms, examining the aspects that influence the decision to adopt a family brand and the impact that this choice has on performance. Finally, in the third chapter it presents a longitudinal analysis (2005-2011), conducted on a sample of 102 family firms belonging to the Italian wine industry. The empirical investigation applies a hierarchical multivariate regression model and tests the moderating effect of branding strategies on the relationship between family involvement and performance. In particular, it analyzes the branding trough a content analysis to the textual content of websites. [edited by Author]
description: Il lavoro di ricerca si inserisce nel controverso dibattito internazionale sulla relazione tra family involvement e performance, introducendo, quale variabile moderatrice della relazione, le strategie di branding adottate dalle imprese familiari. In tal senso, lo studio approccia la problematica adottando una prospettiva olistica, che contempli tanto gli aspetti strutturali, quanto quelli strategici, distintivi delle imprese familiari e in grado di condizionarne i risultati. La tesi presenta, nel primo capitolo, una ricognizione della letteratura internazionale sulla relazione family involvement-performance, condotta attraverso la metodologia della systematic review, e i risultati di una meta-analisi applicata agli studi di natura empirica. Nel secondo, delinea le problematiche di brand management delle imprese familiari, valutando gli aspetti che influenzano la scelta di adottare o meno un family brand e l’impatto che tale opzione ha sulle performance aziendali. Infine, nel terzo capitolo, presenta un’analisi longitudinale (2005-2011), condotta su un campione di 102 imprese familiari italiane afferenti al settore vinicolo. L’indagine empirica testa, attraverso l’applicazione di un modello di regressione gerarchica multivariata, l’effetto moderatore delle strategie di branding sulla relazione tra family involvement e performance. In particolare, analizza le strategie di branding adottate dalle imprese, applicando la content analysis ai contenuti testuali dei siti web. [a cura dell'Autore]
Galaxy Zoo: CANDELS Barred Disks and Bar Fractions
Creators: name: Simmons, B. D.
name: Melvin, Thomas
name: Lintott, Chris
name: Masters, Karen L.
name: Willett, Kyle W.
name: Keel, William C.
name: Smethurst, R. J.
name: Cheung, Edmond
name: Nichol, Robert C.
name: Schawinski, Kevin
name: Rutkowski, Michael
name: Kartaltepe, Jeyhan S.
name: Bell, Eric F.
name: Casteels, Kevin R. V.
name: Conselice, Christopher J.
name: Almaini, Omar
name: Ferguson, Henry C.
name: Fortson, Lucy
name: Hartley, William
name: Kocevski, Dale
name: Koekemoer, Anton M.
name: McIntosh, Daniel H.
name: Mortlock, Alice
name: Newman, Jeffrey A.
name: Ownsworth, Jamie
name: Bamford, Steven
name: Dahlen, Tomas
name: Faber, Sandra M.
name: Finkelstein, Steven L.
name: Fontana, Adriano
name: Galametz, Audrey
name: Grogin, N. A.
name: Grutzbauch, Ruth
name: Guo, Yicheng
name: Haussler, Boris
name: Jek, Kian J.
name: Kaviraj, Sugata
name: Lucas, Ray A.
name: Peth, Michael
name: Salvato, Mara
name: Wiklind, Tommy
name: Wuyts, Stijn
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The formation of bars in disk galaxies is a tracer of the dynamical maturity of the population. Previous studies have found that the incidence of bars in disks decreases from the local Universe to z ~ 1, and by z > 1 simulations predict that bar features in dynamically mature disks should be extremely rare. Here we report the discovery of strong barred structures in massive disk galaxies at z ~ 1.5 in deep rest-frame optical images from CANDELS. From within a sample of 876 disk galaxies identified by visual classification in Galaxy Zoo, we identify 123 barred galaxies. Selecting a sub-sample within the same region of the evolving galaxy luminosity function (brighter than L*), we find that the bar fraction across the redshift range 0.5< z < 2 (f_bar = 10.7 +6.3 -3.5% after correcting for incompleteness) does not significantly evolve. We discuss the implications of this discovery in the context of existing simulations and our current understanding of the way disk galaxies have evolved over the last 11 billion years.
description: 11 pages, 6 figures; accepted for publication in MNRAS
title: Complications of bariatric surgery: what the radiologist needs to know
Creators: name: O'Brien, Amy
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Volvulus
subject: Acute
subject: Surgery
subject: Barium meal
subject: MR
subject: CT
subject: Anatomy
subject: Abdomen
subject: Ischaemia / Infarction
subject: Stomach (incl. Oesophagus)

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Radiological imaging is vital in postoperative evaluation and management of patients of bariatric surgery. This pictorial review will provide the reader with a guide to: 1. Postsurgical anatomy 2. Common complications of bariatric surgery The reader...
Dynamical, biological, and anthropic consequences of equal lunar and solar angular radii
Creators: name: Balbus, Steven A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The nearly equal lunar and solar angular sizes as subtended at the Earth is generally regarded as a coincidence. This is, however, an incidental consequence of the tidal forces from these bodies being comparable. Comparable magnitudes implies strong temporal modulation, as the forcing frequencies are nearly but not precisely equal. We suggest that on the basis of paleogeographic reconstructions, in the Devonian period, when the first tetrapods appeared on land, a large tidal range would accompany these modulated tides. This would have been conducive to the formation of a network of isolated tidal pools, lending support to A.S. Romer's classic idea that the evaporation of shallow pools was an evolutionary impetus for the development of chiridian limbs in aquatic tetrapodomorphs. Romer saw this as the reason for the existence of limbs, but strong selection pressure for terrestrial navigation would have been present even if the limbs were aquatic in origin. Since even a modest difference in the Moon's angular size relative to the Sun's would lead to a qualitatively different tidal modulation, the fact that we live on a planet with a Sun and Moon of close apparent size is not entirely coincidental: it may have an anthropic basis.
description: 12 Pages, 4 figures, To appear Proc Roy Soc (A)
title: Hepatocellular carcinoma in cirrhotic patients: Radiological imaging features and how to use the LIRADS score.
Creators: name: O'Brien, Amy
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Multidisciplinary cancer care
subject: Cancer
subject: Staging
subject: Localisation
subject: Imaging sequences
subject: MR
subject: CT-Angiography
subject: CT
subject: Oncology
subject: Liver
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To appreciate the most important imaging features of hepatocellular carcinoma in cirrhotic patients. To understand the method of using the LI-RADS (liver imaging reporting and data system) scoring system, and how it’s utilized in a major...
Merging the Structural Motifs of Functionalized Amino Acids and α-Aminoamides: Compounds with Significant Anticonvulsant Activities
Creators: name: Kohn, Harold
name: Salomé, Christophe
name: Stables, James P.
name: Salomé-Grosjean, Elise
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Functional amino acids (FAAs) and α-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs) that exhibit pronounced anticonvulsant activities. We combined key structural pharmacophores present in FAAs and AAAs to generate a new series of compounds and document that select compounds exhibit activity superior to either the prototypical FAA (lacosamide) or the prototypical AAA (safinamide) in the maximal electroshock (MES) seizure model in rats. A representative compound, (R)-N-4′-((3″-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide ((R)-10), was tested in the MES (mice, ip), MES (rat, po), psychomotor 6 Hz (32 mA) (mice, ip), and hippocampal kindled (rat, ip) seizure tests providing excellent protection with ED50 values of 13, 14, ~10 mg/kg, and 12 mg/kg, respectively. In the rat sciatic nerve ligation model (ip), (R)-10 (12 mg/kg) provided an 11.2-fold attenuation of mechanical allodynia. In the mouse biphasic formalin pain model (ip), (R)-10 (15 mg/kg) reduced pain responses in the acute and the chronic inflammatory phases.
Evolution of the galaxy luminosity function in progenitors of fossil groups
Creators: name: Gozaliasl, G.
name: Khosroshahi, H. G.
name: Dariush, A. A.
name: Finoguenov, A.
name: Jassur, D. M. Z.
name: Molaeinajad, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Using the semi-analytic models based on the Millennium simulation, we trace back the evolution of the luminosity function of galaxies residing in progenitors of groups classified by the magnitude gap at redshift zero. We determine the luminosity function of galaxies within $ 0.25R_{200}, 0.5R_{200} $, and $R_{200}$ for galaxy groups/clusters. The bright end of the galaxy luminosity function of fossil groups shows a significant evolution with redshift, with changes in $M^*$ by $\sim$ 1-2 mag between $z\sim0.5$ and $z=0$ (for the central $0.5R_{200}$), suggesting that the formation of the most luminous galaxy in a fossil group has had a significant impact on the $M^{*}$ galaxies e.g. it is formed as a result of multiple mergers of the $ M^{*} $ galaxies within the last $\sim5$ Gyr. In contrast, the slope of the faint end, $α$, of the luminosity function shows no considerable redshift evolution and the number of dwarf galaxies in the fossil groups exhibits no evolution, unlike in non-fossil groups where it grows by $\sim25-42\%$ towards low redshifts. In agreement with previous studies, we also show that fossil groups accumulate most of their halo mass earlier than non-fossil groups. Selecting the fossils at a redshift of 1 and tracing them to a redshift 0, we show that $80\%$ of the fossil groups ($10^{13} M_{\odot} h^{-1}10^{14} M_{\odot} h^{-1}$) will retain their large gaps.
description: Accepted for publication in A&A. 13 pages, 15 figures
Nonconventional magnetic order in frustrated diamond lattice antiferromagnet CoAl2O4 studied by neutron diffraction and classical Monte-Carlo simulation
Creators: name: Zaharko, O.
name: Tóth, S.
name: Sendetskyi, O.
name: Cervellino, A.
name: Wolter-Giraud, A.
name: Dey, T.
name: Maljuk, A.
name: Tsurkan, V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: CoAl2O4 spinel with magnetic Co2+ ions on the diamond A-lattice is known to be magnetically frustrated. We compare neutron single crystal diffraction patterns measured in zero and applied magnetic fields with the ones obtained from classical Monte-Carlo models. In simulations we test the influence of various parameters on diffraction patterns: the ratio of nearest-, J1, and next-nearest, J2, neighbor interactions, magnetic field applied along the principal crystallographic directions, and random disorder on the A(Co2+)- and B(Al3+)- sites. We conclude that the models considered so far explain the broadening of magnetic Bragg peaks in zero magnetic field and their anisotropic response to applied magnetic field only partly. As bulk properties of our single crystal are isotropic, we suggest that its microstructure, specifically <111>-twin boundaries, could be a reason of the nonconventional magnetic order in CoAl2O4.
description: 9 pages, 8 figures
title: Information systems development and the analysis of urban change.
Creators: name: Worrall, Les.
Publisher: name: University of Liverpool Repository
Year: 2023

description: The two main aims of the thesis are, first, to improve our understanding of how urban systems adjust and, second, to explain how the social costs of adjustment are distributed among sub-groups within the urban system. The main stimuli to the project were the realisation that the social costs of urban adjustment tend to be concentrated upon those with the least power in the markets which operate within urban areas and the concern that much urban analysis has been undertaken without an adequate information base. Design criteria for urban information systems are developed and the thesis makes use of a unique suite of information systems, which were created to monitor the development of Telford New Town, to achieve the above aims and objectives. The period under study (1978 to 1983) was one of intense demographic, economic and social change in Telford and it is argued that the findings developed from an analysis urban problems in Telford are more generally applicable. Within the thesis, an attempt has been made to integrate theoretical and methodological developments in several areas and to apply them to the analysis of urban change. In particular, recent developments in segmented labour market theory are used as a foundation for a conceptual model of the urban labour market and a behavioural theory of the firm. Recent changes in industrial structure, employment and unemployment are examined in order to test if these changes were consistent with the expectations derived from the theoretical base. The structure of the thesis is straightforward: in Chapter Two a rationale for intervention in the urban system is developed prior to outlining a framework for urban planning and analysis. In Chapters Three, Four and Five, the objectives are to review relevant labour market theory, to develop a conceptual model of an urban labour market and to discuss the urban significance of unemployment. In Chapter Six, recent social, economic and 5lemographic change in Telford is described as a context for subsequent analysis. In Chapter Seven, a suite of local information is described. In Chapters Eight and Nine, recent change in industrial structure, employment and unemployment are analysed to test the validity of the conceptual model of the urban labour market and the related concepts developed in earlier chapters.
Additional file 2 of Characteristics and recovery methods of studies falsely excluded during literature screening—a systematic review
Creators: name: Affengruber, Lisa
name: Dobrescu, Andreea
name: Persad, Emma
name: Klerings, Irma
name: Wagner, Gernot
name: Sommer, Isolde
name: Gartlehner, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Search strategy for Medline, Science Citation Index Expanded, Social Sciences Citation Index, Current Contents Connect, Embase, Epistemonikos.org, and Information Science & Technology Abstracts.
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.
Creators: name: Janzen, William P.
name: Arrowsmith, Cheryl H.
name: Chau, Irene
name: Senisterra, Guillermo
name: Vedadi, Masoud
name: Jin, Jian
name: Simeonov, Anton
name: Kireev, Dmitri B.
name: Quinn, Amy M.
name: Norris, Jacqueline L.
name: Liu, Feng
name: Wasney, Gregory A.
name: Jadhav, Ajit
name: Herold, J. Martin
name: Dong, Aiping
name: Siarheyeva, Alena
name: Chen, Xin
name: Brown, Peter J.
name: Frye, Stephen V.
name: Allali-Hassani, Abdellah
name: Wigle, Tim J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is over expressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth and the di-methylation of p53 K373 results in the inactivation of p53. Initial SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template represented by 3a (BIX01294), a selective small molecule inhibitor of G9a and GLP, led to the discovery of 10 (UNC0224) as a potent G9a inhibitor with excellent selectivity. A high resolution X-ray crystal structure of the G9a-10 complex, the first co-crystal structure of G9a with a small molecule inhibitor, was obtained. Based on the structural insights revealed by this co-crystal structure, optimization of the 7-dimethylaminopropoxy side chain of 10 resulted in the discovery of 29 (UNC0321) (Morrison Ki = 63 pM), which is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date.
Anticipation and Apprehension in Fiji’s 2022 General Election
Creators: name: Singh, Shailendra
Publisher: name: Canberra, ACT: Dept. of Pacific Affairs, Coral Bell School of Asia Pacific Affairs, The Australian National University
Year: 2022
Subjects: Pacific
Fiji
Elections
Democracy
Politics
Military Coup
Nature of the State

description: In Fiji’s politically charged context, national elections are historically a risky period. Since the 2022 campaign period was declared open on 26 April, the intensity has been increasing. With three governments toppled by coups after the 1987, 1999 and 2006 elections, concerns about a smooth transfer of power in 2022 are part of the national discourse.
title: Preoperative sentinel lymph node identification and biopsy using intradermal microbubbles and contrast enhanced ultrasound (CEUS)
Creators: name: Sharma, Nisha
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: Ultrasound
subject: Biopsy
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Axillary lymph node status is an important prognostic factor for recurrence and survival in patients with breast cancer and guides adjuvant treatment decisions.(1) The less invasive surgical sentinel lymph node biopsy (SLNB) for patients with...
It is hard to see a needle in a haystack: Modeling contrast masking effect in a numerical observer
Creators: name: Avanaki, Ali R. N.
name: Espig, Kathryn S.
name: Xthona, Albert
name: Kimpe, Tom R. L.
name: Bakic, Predrag R.
name: Maidment, Andrew D. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Within the framework of a virtual clinical trial for breast imaging, we aim to develop numerical observers that follow the same detection performance trends as those of a typical human observer. In our prior work, we showed that by including spatiotemporal contrast sensitivity function (stCSF) of human visual system (HVS) in a multi-slice channelized Hotelling observer (msCHO), we can correctly predict trends of a typical human observer performance with the viewing parameters of browsing speed, viewing distance and contrast. In this work we further improve our numerical observer by modeling contrast masking. After stCSF, contrast masking is the second most prominent property of HVS and it refers to the fact that the presence of one signal affects the visibility threshold for another signal. Our results indicate that the improved numerical observer better predicts changes in detection performance with background complexity.