Additional file 1 of Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts
Creators: name: Lowry, Estelle
name: Rautio, Nina
name: Wasenius, Niko
name: Bond, Tom A.
name: Lahti, Jari
name: Tzoulaki, Ioanna
name: Dehghan, Abbas
name: Heiskala, Anni
name: Ala-Mursula, Leena
name: Miettunen, Jouko
name: Eriksson, Johan
name: Marjo-Riitta Järvelin
name: Sebert, Sylvain
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table 1A. Variable selection in Helsinki Birth Cohort Study 1934–1944 (✓ included, ✗ excluded). Table 1B. Variable selection in Northern Finland Birth Cohort 1966 (✓ included, ✗ excluded). Table 1C. Variable selection in Northern Finland Birth Cohort 1986 (✓ included, ✗ excluded). Table 2. Social disadvantage variables with their original categorizations and coding used within confirmatory factor analysis in early life in Helsinki Birth Cohort Study 1934–1944 (HBCS1934–1944), Northern Finland Birth Cohort 1966 (NFBC1966), and Northern Finland Birth Cohort Study 1986 (NFBC1986) and at age of 44-years in HBCS1934–1944 and 46-years in NFBC1966. Text 1. Genotype quality control for NFBC1966 and more detailed information concerning calculation of polygenic risk score for body mass index (BMI). Table 3. Association of early social disadvantage with visceral fat area (cm2), waist circumference (cm) and body fat (%) at 46-years in Northern Finland Birth Cohort 1966 (NFBC1966). Table 4. Association between early social disadvantage with visceral fat area (cm2) at age of 46-years in Northern Finland Birth Cohort 1966 (NFBC1966, n = 3294). Low social disadvantage was set as a reference group. Table 5. Associations between early social disadvantage with waist circumference (cm) and body fat (%) at age of 46-years in men and in women in Northern Finland Birth Cohort 1966 (NFBC1966). Low social disadvantage was set as a reference group. Table 6. Association of change in social disadvantage during the life-course with visceral fat area (cm2) at age of 46-years in Northern Finland Birth Cohort (NFBC1966, n = 3293). Increased social disadvantage was set as a reference group. Table 7. Association of change in social disadvantage during the lifecourse with waist circumference (cm) and body fat (%) at age of 46-years in men and women in Northern Finland Birth Cohort 1966 (NFBC1966). Increased social disadvantage was set as a reference group. Figure 1. Directed acyclic diagram (DAG) for the tested association. We may hypothesise the association between exposure to early social disadvantage to be the result of co-existing pathways. This includes the possible interplay with the child polygenic risk score for BMI that might in part proxy some confounding effects of his/her parents’ BMI.