title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐµÐ·Ð¾Ð½Ð½ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ ÑÐ¾ÑÑÐ°Ð²Ð° Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð²ÐµÑÐµÑÑÐ² Ð¸Ð· Fucus vesiculosus ÐÐ°ÑÐµÐ½ÑÐµÐ²Ð° Ð¼Ð¾ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: A study of seasonal variations in the composition and biological activity of compounds extracted from Fucus vesiculosus collected in the Barents Sea
Creators: name: ÐÑÐ¼Ð¸Ð»Ð¾Ð², Ð¤Ð¸Ð»Ð¸Ð¿Ð¿
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: fucus vesiculosus
ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½
Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½ÑÐµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ
Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐµÐ·Ð¾Ð½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ
fucoidan
polyphenolic compounds
biological activity
seasonal variation

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¼ÐµÐ¶Ð´Ñ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐ¼ Ð¸ ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐ¼ ÑÐ¾ÑÑÐ°Ð²Ð¾Ð¼ Ð²ÐµÑÐµÑÑÐ², Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð½ÑÑ Ð¸Ð· Fucus vesiculosus ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼Ð¸ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸, Ð¸ Ð¸Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¾Ñ ÑÐµÐ·Ð¾Ð½Ð° ÑÐ±Ð¾ÑÐ° Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÑÐ°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: Ð¿Ð¾Ð´Ð±Ð¾Ñ Ð¼ÐµÑÐ¾Ð´Ð° ÑÐºÑÑÑÐ°ÐºÑÐ¸Ð¸ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ðµ ÑÑÐ°ÐºÑÐ¸Ð¹ Ð½ÐµÐ¾ÑÐ¸ÑÐµÐ½Ð½ÑÑ Ð¸ Ð¾ÑÐ¸ÑÐµÐ½Ð½ÑÑ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð¾Ð² Ð¸ ÑÑÐ°ÐºÑÐ¸Ð¸ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹; Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¸ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð½ÑÑ ÑÑÐ°ÐºÑÐ¸Ð¹ Ð¼ÐµÑÐ¾Ð´Ð°Ð¼Ð¸, Ð¾ÑÑÐ°Ð¶Ð°ÑÑÐ¸Ñ Ð¸Ñ ÑÐ¾ÑÑÐ°Ð² Ð¸ ÑÑÑÑÐºÑÑÑÑ ÑÐµÐ»ÐµÐ²ÑÑ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ¾Ð²; Ð¾ÑÐµÐ½ÐºÐ° Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ DPPH; Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð±Ð°ÐºÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÐºÑÐ»ÑÑÑÑ; Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ðµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐµÐ¹ Ð¼ÐµÐ¶Ð´Ñ ÑÐµÐ·Ð¾Ð½Ð¾Ð¼ ÑÐ±Ð¾ÑÐ° Ð¸ÑÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ ÑÑÑÑÑ, Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÑÐºÑÑÑÐ°ÐºÑÐ¸Ð¸ Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ñ ÑÐµÐ»ÑÑ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²ÑÐµÐ¼ÐµÐ½Ð¸ ÑÐ±Ð¾ÑÐ° Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ F. vesiculosus. ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»Ð¸ Ð²Ð¸Ð´Ð° Fucus vesiculosus, ÑÐ¾Ð±ÑÐ°Ð½Ð½ÑÐµ Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ ÑÐµÐ·Ð¾Ð½Ñ (Ð²ÐµÑÐ½Ð°, Ð»ÐµÑÐ¾ Ð¸ Ð¾ÑÐµÐ½Ñ) Ð½Ð° Ð¿Ð¾Ð±ÐµÑÐµÐ¶ÑÐµ ÐÐ°ÑÐµÐ½ÑÐµÐ²Ð° Ð¼Ð¾ÑÑ Ð² Ð¾ÐºÑÐµÑÑÐ½Ð¾ÑÑÑÑ Ð¢ÐµÑÐ¸Ð±ÐµÑÐºÐ¸, ÑÐµÐ»Ð° Ð² ÐÑÑÐ¼Ð°Ð½ÑÐºÐ¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸. Ð Ð°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð±Ð¸Ð¾ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¾ÑÐ´ÐµÐ»Ð° Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð¸ ÑÐ°Ð´Ð¸Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð±Ð¸Ð¾ÑÐ¸Ð·Ð¸ÐºÐ¸ ÐÐÐ¦ Â«ÐÑÑÑÐ°ÑÐ¾Ð²ÑÐºÐ¸Ð¹ Ð¸Ð½ÑÑÐ¸ÑÑÑÂ» â ÐÐÐ¯Ð¤. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¸Ð· Fucus vesiculosus Ð²ÑÐ´ÐµÐ»ÐµÐ½Ñ ÑÑÐ¸ ÑÑÐ°ÐºÑÐ¸Ð¸ ÐÐÐ: Ð½ÐµÐ¾ÑÐ¸ÑÐµÐ½Ð½ÑÐ¹ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½ (ÐÐ¤), Ð¾ÑÐ¸ÑÐµÐ½Ð½ÑÐ¹ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½ (ÐÐ¤) Ð¸ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½Ð°Ñ ÑÑÐ°ÐºÑÐ¸Ñ (ÐÐ¤). ÐÐ°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ðµ ÐÐ¤ Ð¸ ÐÐ¤ Ð½Ð°Ð±Ð»ÑÐ´Ð°ÐµÑÑÑ Ð² Ð¾ÑÐµÐ½Ð½ÐµÐ¼ ÑÐµÐ·Ð¾Ð½Ðµ (7,30% Ð¸ 54,71 % ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾), Ð° ÐÐ¤ Ð² Ð»ÐµÑÐ½ÐµÐ¼ (7,73 %). ÐÐ½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð²ÑÐ´ÐµÐ»ÐµÐ½Ð½ÑÑ ÑÑÐ°ÐºÑÐ¸Ð¹ Ð¾Ð±ÑÑÐ»Ð°Ð²Ð»Ð¸Ð²Ð°ÐµÑÑÑ Ð½Ð°Ð»Ð¸ÑÐ¸ÐµÐ¼ Ð² ÑÐ¾ÑÑÐ°Ð²Ðµ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹, Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÑÑÑÐ°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÑÐ°ÐºÑÐ¸Ð¸ ÐºÐ¾ÑÐ¾ÑÑÑ Ð¿ÑÐ¸Ð±Ð»Ð¸Ð¶Ð°ÐµÑÑÑ Ðº 90%. ÐÐ½ÑÐ¸Ð±Ð°ÐºÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½Ð¾Ð¹ ÑÑÐ°ÐºÑÐ¸Ð¸ Ð¿ÑÐ¸ÑÑÑÑÑÐ²ÑÐµÑ ÑÐ¾Ð»ÑÐºÐ¾ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð³ÑÐ°Ð¼Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð±Ð°ÐºÑÐµÑÐ¸Ð¹. ÐÐ¾Ð»Ð¸ÑÐ°ÑÐ°ÑÐ¸Ð´Ð½Ð°Ñ ÑÑÐ°ÐºÑÐ¸Ñ Ð¿ÑÐ¾ÑÐ²Ð»ÑÐµÑ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÑÑÑÐµÐµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð° Ð²ÑÐµ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÐµ Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÐµ ÐºÑÐ»ÑÑÑÑÑ. ÐÑÐ¸ÑÑÑÑÑÐ²Ð¸Ðµ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¾Ð»ÑÐ½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð² ÑÐ¾ÑÑÐ°Ð²Ðµ Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð²Ð»Ð¸ÑÐµÑ Ð½Ð° Ð°Ð½ÑÐ¸Ð±Ð°ÐºÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÐµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼ÑÑ ÑÑÐ°ÐºÑÐ¸Ð¹. ÐÐ°Ð¸Ð±Ð¾Ð»ÑÑÐµÐµ Ð°Ð½ÑÐ¸Ð±Ð°ÐºÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¾Ð±Ð½Ð°ÑÑÐ¶Ð¸Ð²Ð°Ð»Ð¾ÑÑ Ñ Ð½ÐµÐ¾ÑÐ¸ÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð¾ÑÐµÐ½Ð½ÐµÐ³Ð¾ Ð¸ Ð»ÐµÑÐ½ÐµÐ³Ð¾ ÑÐµÐ·Ð¾Ð½Ð°. ÐÐ°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐ¼ ÑÐµÐ·Ð¾Ð½Ð¾Ð¼ Ð´Ð»Ñ ÑÐ±Ð¾ÑÐ° Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ ÑÐ²Ð»ÑÐµÑÑÑ Ð¾ÑÐµÐ½Ñ, Ð¿Ð¾ÑÐºÐ¾Ð»ÑÐºÑ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½Ð°Ñ ÑÑÐ°ÐºÑÐ¸Ñ Ð½ÐµÐ¾ÑÐ¸ÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÐµÑÑÑ Ð¼Ð°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð¹ Ð°Ð½ÑÐ¸Ð±Ð°ÐºÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð¸ Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¾Ð±ÑÐµÐ´Ð¸Ð½ÑÐµÑ Ð² ÑÐµÐ±Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° ÐÐ¤ Ð¸ ÐÐ¤.Â  ÐÑÐ¸ Ð½Ð°Ð¿Ð¸ÑÐ°Ð½Ð¸Ð¸ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±Ð·Ð¾ÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð±Ð°Ð·Ñ Ð´Ð°Ð½Ð½ÑÑ: ÐÐºÐ°Ð´ÐµÐ¼Ð¸Ñ Google, eLIBRARY, PubMed. ÐÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð² Ð²Ð¸Ð´Ðµ ÑÐ¾ÑÐ¾Ð³ÑÐ°ÑÐ¸Ð¹ ÑÐ°ÑÐµÐº ÐÐµÑÑÐ¸, Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Adobe Photoshop Ð¸ Adobe Illustrator. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð°ÐºÐµÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Microsoft Excel Ð¸ OriginPro.
description: This work is devoted to the study of the dependence between the quantitative and qualitative composition of substances isolated from Fucus vesiculosus by various methods and their biological activity on the season of algae harvesting. The following tasks were solved in the study: selection of a method for extracting polyphenolic compounds and obtaining fractions of crude and purified fucoidans and fractions of polyphenolic compounds; investigation and characterization of the selected fractions by methods reflecting their composition and structure of the target components; assessment of antioxidant activity by DPPH method; study of antimicrobial activity against bacterial cultures; identification of dependencies between the harvesting season of the feedstock, the extraction method and biological activity in order to identify the optimal time for harvesting F. vesiculosus algae. The study focuses on algae of the Fucus vesiculosus species, which were collected in different seasons (spring, summer, and autumn) from the coast of the Barents Sea near Teriberka, a village located in the Murmansk Region. The work was conducted at the Laboratory of Biotechnology within the Department of Molecular and Radiation Biophysics at the Kurchatov Institute Research Center â PNPI. During the course of the study, three fractions of biologically active substances were isolated from Fucus vesiculosus: crude fucoidan (CF), purified fucoidan (OF), and polyphenolic fraction (PF). The highest content of CF and PF was observed in the autumn (7.30% and 54.71% respectively), while OF had the highest concentration in the summer season (7.73%). The antioxidant activity of the isolated fractions can be attributed to the presence of polyphenolic compounds, with an inhibitory activity approaching 90% for the fraction. The antibacterial activity of the polyphenolic fraction was only effective against Grampositive bacteria, while the polysaccharide fraction exhibited inhibitory effects on all microbial cultures studied. The presence of polyphenols significantly influences the antibacterial properties of fucoidans, with the greatest antibacterial effect being observed in crude fucoidan from the autumn and summer seasons. The most suitable time for algae harvesting is in autumn, as the resulting crude fucoidan fraction exhibits maximum antibacterial and antioxidant activity. This fraction also combines the characteristics of PF (polyphenolic fraction) and OF (purified fucoidan). When writing the literature review, the following databases were consulted: Google Scholar, eLIBRARY, and PubMed. Qualitative analysis of experimental data, obtained in the form of photos of Petri dishes, was carried out using Adobe Photoshop and Adobe Illustrator. Statistical analysis of the experimental data was performed using Microsoft Excel and the OriginPro software package.