cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
G Protein-regulated Inducer of Neurite Outgrowth (GRIN) Modulates Sprouty Protein Repression of Mitogen-activated Protein Kinase (MAPK) Activation by Growth Factor Stimulation
Creators: name: Premsrirut, Prem K.
name: Licht, Jonathan D.
name: Iyengar, Ravi
name: Jayamaran, Gomathi
name: Jordan, J. Dedrick
name: Hwangpo, Anh
name: Neves, Susana R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Gαo/i interacts directly with GRIN (G protein-regulated inducer of neurite outgrowth). Using the yeast two-hybrid system, we identified Sprouty2 as an interacting partner of GRIN. Gαo and Sprouty2 bind to overlapping regions of GRIN, thus competing for GRIN binding. Imaging experiments demonstrated that Gαo expression promoted GRIN translocation to the plasma membrane, whereas Sprouty2 expression failed to do so. Given the role of Sprouty2 in the regulation of growth factor-mediated MAPK activation, we examined the contribution of the GRIN-Sprouty2 interaction to CB1 cannabinoid receptor regulation of FGF receptor signaling. In Neuro-2A cells, a system that expresses all of the components endogenously, modulation of GRIN levels led to regulation of MAPK activation. Overexpression of GRIN potentiated FGF activation of MAPK and decreased tyrosine phosphorylation of Sprouty2. Pretreatment with Go/i-coupled CB1 receptor agonist attenuated subsequent FGF activation of MAPK. Decreased expression of GRIN both diminished FGF activation of MAPK and blocked CB1R attenuation of MAPK activation. These observations indicate that Gαo interacts with GRIN and outcompetes GRIN from bound Sprouty. Free Sprouty then in turn inhibits growth factor signaling. Thus, here we present a novel mechanism of how Go/i-coupled receptors can inhibit growth factor signaling to MAPK.
LES ÉPIBIONTES ANIMAUX DE LITTORINA OBTUSATA (L.) ET DE L. MARIAE SACCHI ET RAST. (GASTROPODA, PROSOBRANCHIA)
Creators: name: SACCHI, Cesare F.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: Twelve animal epibiotic species were found living upon living shells of Littorina obtusata (L.) and L. mariae Sacchi and Rast, (see table A).
The commonest of all is Elminius modestus Darwin, a barnacle widespread alongtheAtlanticcoasts of Europe. Elminius seems to prefer "dark" coloured shells (see table C).
Nosignificantdifferencecan be demonstrated between the sexes of Littorina concerning epibiosis (table D).
No living shell was found to support two or more different epibiotic species, while several individuals of the same species may often be found (table E).
Elminius modestus is more frequent on Littorina obtusata; Spirorbis pagenstecheri, the next species in frequency, is more common on L. mariae (table B). Such a difference is probably related mainly to bionomie and bathymetric distribution both of periwinkles and fouling species, as the latter only occur among the more invasive ones.
Living shells of L. obtusata and L. mariae do not offer convenient substrata for too many marine species: they are small, smooth, globose and lack good niches for a “rugophilic" settlement. Consequently, only animals endowed with the highest ecological valence can spread from more favourable surrounding substrata to L. obtusata and L. mariae.
This settlement takes place by means of the huge number of larvae and the great adaptability of juvenile forms : so the twelve epibionts of L. obtusata and L. mariae range themselves among the commonest fouling species occurring between the tidemarks.
ÉVOLUTIONS ET INTERACTIONS TISSULAIRES AU COURS DE LA RÉGÉNÉRATION DES LÈVRES DE BEROE OVATA (CHAM ISSO ET EYSENHARDT), CTÉNAIRE NUDICTÉNIDE
Creators: name: FRANC, Jean-Marie
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: An investigation on regeneration of the lips of Beroe ovata with light and electron microscopes, has allowed us to follow , both at the cellular and tissular levels, the events leading to re-edification of this structure, perfectly integrated to the whole organism.
In Ctenaria, ectodermal and endodermal epithelia are separated by mesenchymal tissue derivated from a true mesoderm. Moreover, the mouth ectoderm exhibits three annular areas differentiating respectively sensory, glandular and ciliated cells. Such structures form a suitable model for a survey of histogenetic
system s and their cell-differentiations. The course of regeneration points out the specificity of the three basic layers
(ecto-, endo-, and meso-derms), each of these ones show ing its own cellular transformations. These transformations are obvious for m uscular-cells. Their stability or changes are conditioned by fonctionnai state of the complex “cell-basal membrane-internal medium”. However, the restoration of buccal epithelium gives evidence for tissueinteraction. So, the differentiation of annular areas in this healed epithelium seems to result from an unspecific activation produced by differentiating tissues,
and from a specific inhibition provided by the already differentiated cells.
G-protein Signaling Modulator-3 Regulates Heterotrimeric G-protein Dynamics through Dual Association with Gβ and Gα i Protein Subunits
Creators: name: Oestreich, Emily A.
name: Laroche, Geneviève
name: Giguère, Patrick M.
name: Siderovski, David P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Regulation of the assembly and function of G-protein heterotrimers (Gα·GDP/Gβγ) is a complex process involving the participation of many accessory proteins. One of these regulators, GPSM3, is a member of a family of proteins containing one or more copies of a small regulatory motif known as the GoLoco (or GPR) motif. Although GPSM3 is known to bind Gαi·GDP subunits via its GoLoco motifs, here we report that GPSM3 also interacts with the Gβ subunits Gβ1 to Gβ4, independent of Gγ or Gα·GDP subunit interactions. Bimolecular fluorescence complementation studies suggest that the Gβ-GPSM3 complex is formed at, and transits through, the Golgi apparatus and also exists as a soluble complex in the cytoplasm. GPSM3 and Gβ co-localize endogenously in THP-1 cells at the plasma membrane and in a juxtanuclear compartment. We provide evidence that GPSM3 increases Gβ stability until formation of the Gβγ dimer, including association of the Gβ-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gβ subunits. The Gβ interaction site within GPSM3 was mapped to a leucine-rich region proximal to the N-terminal side of its first GoLoco motif. Both Gβ and Gαi·GDP binding events are required for GPSM3 activity in inhibiting phospholipase-Cβ activation. GPSM3 is also shown in THP-1 cells to be important for Akt activation, a known Gβγ-dependent pathway. Discovery of a Gβ/GPSM3 interaction, independent of Gα·GDP and Gγ involvement, adds to the combinatorial complexity of the role of GPSM3 in heterotrimeric G-protein regulation.
Additional file 1 of Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation
Creators: name: Kunadt, Desiree
name: Stasik, Sebastian
name: Metzeler, Klaus H.
name: Röllig, Christoph
name: Schliemann, Christoph
name: Greif, Philipp A.
name: Spiekermann, Karsten
name: Rothenberg-Thurley, Maja
name: Krug, Utz
name: Braess, Jan
name: Krämer, Alwin
name: Hochhaus, Andreas
name: Scholl, Sebastian
name: Hilgendorf, Inken
name: Brümmendorf, Tim H.
name: Jost, Edgar
name: Steffen, Björn
name: Bug, Gesine
name: Einsele, Hermann
name: Görlich, Dennis
name: Sauerland, Cristina
name: Schäfer-Eckart, Kerstin
name: Krause, Stefan W.
name: Hänel, Mathias
name: Hanoun, Maher
name: Kaufmann, Martin
name: Wörmann, Bernhard
name: Kramer, Michael
name: Sockel, Katja
name: Egger-Heidrich, Katharina
name: Herold, Tobias
name: Ehninger, Gerhard
name: Burchert, Andreas
name: Platzbecker, Uwe
name: Berdel, Wolfgang E.
name: Müller-Tidow, Carsten
name: Hiddemann, Wolfgang
name: Serve, Hubert
name: Stelljes, Matthias
name: Baldus, Claudia D.
name: Neubauer, Andreas
name: Schetelig, Johannes
name: Thiede, Christian
name: Bornhäuser, Martin
name: Middeke, Jan M.
name: Stölzel, Friedrich
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Table S1 Overview of the clinical trials the study patients were selected from. Figure S1 Forrest Plot of variables evaluated in univariate analysis. Multivariate Cox proportional hazard regression for (A) overall survival and (B) relapse-free survival.
Headless Myo10 Is a Negative Regulator of Full-length Myo10 and Inhibits Axon Outgrowth in Cortical Neurons
Creators: name: Cheney, Richard E.
name: Kerber, Michael L.
name: Raines, Alexander N.
name: Nagdas, Sarbajeet
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Myo10 is an unconventional myosin that localizes to and induces filopodia, structures that are critical for growing axons. In addition to the ∼240-kDa full-length Myo10, brain expresses a ∼165 kDa isoform that lacks a functional motor domain and is known as headless Myo10. We and others have hypothesized that headless Myo10 acts as an endogenous dominant negative of full-length Myo10, but this hypothesis has not been tested, and the function of headless Myo10 remains unknown. We find that cortical neurons express both headless and full-length Myo10 and report the first isoform-specific localization of Myo10 in brain, which shows enrichment of headless Myo10 in regions of proliferating and migrating cells, including the embryonic ventricular zone and the postnatal rostral migratory stream. We also find that headless and full-length Myo10 are expressed in embryonic and neuronal stem cells. To directly test the function of headless and full-length Myo10, we used RNAi specific to each isoform in mouse cortical neuron cultures. Knockdown of full-length Myo10 reduces axon outgrowth, whereas knockdown of headless Myo10 increases axon outgrowth. To test whether headless Myo10 antagonizes full-length Myo10, we coexpressed both isoforms in COS-7 cells, which revealed that headless Myo10 suppresses the filopodia-inducing activity of full-length Myo10. Together, these results demonstrate that headless Myo10 can function as a negative regulator of full-length Myo10 and that the two isoforms of Myo10 have opposing roles in axon outgrowth.
Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Creators: name: Van Lancker, Kelly
name: Tarima, Sergey
name: Bartlett, Jonathan
name: Bauer, Madeline
name: Bharani-Dharan, Bharani
name: Bretz, Frank
name: Flournoy, Nancy
name: Michiels, Hege
name: Parra, Camila Olarte
name: Rosenberger, James L
name: Cro, Suzie
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: The COVID-19 pandemic continues to affect the conduct of clinical trials globally. Complications may arise from pandemic-related operational challenges such as site closures, travel limitations and interruptions to the supply chain for the investigational product, or from health-related challenges such as COVID-19 infections. Some of these complications lead to unforeseen intercurrent events in the sense that they affect either the interpretation or the existence of the measurements associated with the clinical question of interest. In this article, we demonstrate how the ICH E9(R1) Addendum on estimands and sensitivity analyses provides a rigorous basis to discuss potential pandemic-related trial disruptions and to embed these disruptions in the context of study objectives and design elements. We introduce several hypothetical estimand strategies and review various causal inference and missing data methods, as well as a statistical method that combines unbiased and possibly biased estimators for estimation. To illustrate, we describe the features of a stylized trial, and how it may have been impacted by the pandemic. This stylized trial will then be re-visited by discussing the changes to the estimand and the estimator to account for pandemic disruptions. Finally, we outline considerations for designing future trials in the context of unforeseen disruptions.
Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere
Creators: name: Griffith, Jack D.
name: Arat, N. Özlem
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The TRF2-Rap1 complex suppresses non-homologous end joining and interacts with DNAPK-C to prevent end joining. We previously demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and recognizes three- and four-way junctions independent of DNA sequence. How the DNA binding characteristics of hTRF2 to DNA is altered in the presence of hRap1 however is not known. Here we utilized EM and quantitative gel retardation to characterize the DNA binding properties of hRap1 and the TRF2-Rap1 complex. Both gel filtration chromatography and mass analysis from two-dimensional projections showed that the TRF2-Rap1 complex exists in solution and binds to DNA as a complex consisting of four monomers each of hRap1 and hTRF2. EM revealed for the first time that hRap1 binds to DNA templates in the absence of hTRF2 with a preference for double strand-single strand junctions in a sequence independent manner. When hTRF2 and hRap1 are in a complex, its affinity for ds telomeric sequences is 2-fold higher than TRF2 alone and more than 10-fold higher for telomeric 3′ ends. This suggests that as hTRF2 recruits hRap1 to telomeric sequences, hRap1 alters the affinity of hTRF2 and its binding preference on telomeric DNA. Moreover, the TRF2-Rap1 complex has higher ability to re-model telomeric DNA than either component alone. This finding underlies the importance of complex formation between hRap1 and hTRF2 for telomere function and end protection.
Weighted Approach for Estimating Effects in Principal Strata with Missing Data for a Categorical Post-Baseline Variable in Randomized Controlled Trials
Creators: name: Kong, Shengchun
name: Heinzmann, Dominik
name: Lauer, Sabine
name: Lu, Tian
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: This research was motivated by studying anti-drug antibody (ADA) formation and its potential impact on long-term benefit of a biologic treatment in a randomized controlled trial, in which ADA status was not only unobserved in the control arm but also in a subset of patients from the experimental treatment arm. Recent literature considers the principal stratum estimand strategy to estimate treatment effect in groups of patients defined by an intercurrent status, i.e. in groups defined by a post-randomization variable only observed in one arm and potentially associated with the outcome. However, status information might be missing even for a non-negligible number of patients in the experimental arm. For this setting, a novel weighted principal stratum approach, namely weighted imputation regression (WRI), is presented: Data from patients with missing intercurrent event status were re-weighted based on baseline covariates and additional longitudinal information. A theoretical justification of the WRI method is provided for different types of outcomes, and assumptions allowing for causal conclusions on treatment effect are specified and investigated. Simulations demonstrated that the WRI method yielded valid inference and was robust against certain violations of assumptions. The method was shown to perform well in a clinical study with ADA status as an intercurrent event.
(3951) Muriel Georgina Stark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Screening algae strains of Chlorella sp. and Dunaliella salina with resistance to oil pollution and their lipid enrichment by using petroleum hydrocarbons
Creators: name: WANG, Tong
name: LIANG, Yizhi
name: WANG, Xuhao
name: NING, Shuxiang
name: LI, Tiesong
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: A plan was put in practice to screen algae strains of Chlorella sp. and Dunaliella salina with resistance to oil pollution and find out if they can enrich lipid in cells cultured in the seawater with petroleum hydrocarbons. The original algal strains were selected by single-cell separation technology and ultraviolet mutation breeding techniques. The growth- dominant algae strains were selected for biochemical components analysis. The biochemical components were analysed by biuret method, sulfuric acid anthrone method and spectrophotometer. The contents of the compounds with conjugated hydrocarbon and petroleum aromatic hydrocarbons were determined respectively by UV spectrophotometry and fluorescence spectrophotometry. The lipid contents of the microalgae cells were measured by the Soxhlet extraction method. As a result, Chlorella sp. A16 and Dunaliella salina A001 were the most vigorous growth predominant strains by biochemical analysis and growth curve. The two kinds of microalgae showed a significant increase (p < 0.5) at the oil concentration of 5 µg.mL-1. Both of the two microalgae can degrade and utilize hydrocarbons and petroleum aromatics effectively at lower oil concentrations. When the oil concentration was 1.5 µg.mL-1 or 3.5 µg.mL-1, the intracellular lipid content in two microalgae increased rapidly and reached the peak between 12-15 days.
(3953) Lois Stark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A4-based see-saw model for realistic neutrino masses and mixing
Creators: name: Pramanick, Soumita
name: Raychaudhuri, Amitava
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present an $A4$-based model where neutrino masses arise from a combination of see-saw mechanisms. The model is motivated by several small mixing and mass parameters indicated by the data. These are $θ_{13}$, the solar mass splitting, and the small deviation of $θ_{23}$ from maximal mixing (= $π/4$). We take the above as indications that at some level the small quantities are well-approximated by zero. In particular the mixing angles, to a zero order, should be either 0 or $π/4$. Accordingly, in this model the Type-II see-saw dominates and generates the larger atmospheric mass splitting and sets $θ_{23} = π/4$. The other mixing angles are vanishing as is the solar splitting. We show how the $A4$ assignment for the lepton doublets leads to this form. We also specify the $A4$ properties of the right-handed neutrinos which result in a smaller Type-I see-saw contribution that acts as a perturbation and shifts the angles $θ_{12}$ and $θ_{13}$ into the correct range and the desired value of $Δm^2_{solar}$ is produced. The $A4$ symmetry results in relationships between these quantities as well as with a small deviation of $θ_{23}$ from $π/4$. If the right-handed neutrino mass matrix, $M_R$, is chosen real then there is no leptonic CP-violation and only Normal Ordering is admissible. If $M_R$ is complex then Inverted Ordering is also allowed with the proviso that the CP-phase, $δ$, is large, i.e., $\sim π/2$ or $-π/2$. The preliminary results from NO$ν$A favouring Normal Ordering and $δ$ near $-π/2$ imply quasi-degenerate neutrino masses in this model.
description: v2: 23 pages, 3 figures, Appendix on scalar potential minimization added, Matches with the published version
Quantum Telescopes: feasibility and constrains
Creators: name: Kurek, A. R.
name: Pięta, T.
name: Stebel, Tomasz
name: Pollo, A.
name: Popowicz, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences
subject: 85-05

description: Quantum Telescope is a recent idea aimed at beating the diffraction limit of spaceborne telescopes and possibly also other distant target imaging systems. There is no agreement yet on the best setup of such devices, but some configurations have been already proposed. In this Letter we characterize the predicted performance of Quantum Telescopes and their possible limitations. Our extensive simulations confirm that the presented model of such instruments is feasible and the device can provide considerable gains in the angular resolution of imaging in the UV, optical and infrared bands. We argue that it is generally possible to construct and manufacture such instruments using the latest or soon to be available technology. We refer to the latest literature to discuss the feasibility of the proposed QT system design.
description: Optics Letters - published after major revision
The VLT-FLAMES Tarantula survey XX. The nature of the X-ray bright emission line star VFTS 399
Creators: name: Clark, J. S.
name: Bartlett, E. S.
name: Broos, P. S.
name: Townsley, L. K.
name: Taylor, W. D.
name: Walborn, N. R.
name: Bird, A. J.
name: Sana, H.
name: de Mink, S. E.
name: Dufton, P. L.
name: Evans, C. J.
name: Langer, N.
name: Apellániz, J. Maíz
name: Schneider, F. R. N.
name: Soszyński, I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The stellar population of the 30 Doradus star-forming region in the Large Magellanic Cloud contains a subset of apparently single, rapidly rotating O-type stars. The physical processes leading to the formation of this cohort are currently uncertain. One member of this group, the late O-type star VFTS 399, is found to be unexpectedly X-ray bright for its bolometric luminosity - in this study we aim to determine its physical nature and the cause of this behaviour. We find VFTS 399 to be an aperiodic photometric variable with an apparent near-IR excess. Its optical spectrum demonstrates complex emission profiles in the lower Balmer series and select HeI lines - taken together these suggest an OeBe classification. The highly variable X-ray luminosity is too great to be produced by a single star, while the hard, non-thermal nature suggests the presence of an accreting relativistic companion. Finally, the detection of periodic modulation of the X-ray lightcurve is most naturally explained under the assumption that the accretor is a neutron star. VFTS 399 appears to be the first high-mass X-ray binary identified within 30 Dor. Comparison of the current properties of VFTS 399 to binary-evolution models suggests a progenitor mass in excess of 25Msun for the putative neutron star, which may host a magnetic field comparable in strength to those of magnetars. VFTS 399 is now the second member of the cohort of rapidly rotating `single' O-type stars in 30 Dor to show evidence of binary interaction resulting in spin-up, suggesting that this may be a viable evolutionary pathway for the formation of a subset of this stellar population.
description: 12 pages, 8 figures, accepted for publication in Astronomy and Astrophysics
(3957) William Orr Leitch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Temperature gradients through building envelopes
Creators: name: Latta, J. K.
name: Garden, G. K.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1962
Subjects: subject: Building envelope
valueUri: urn:ircsubjects:IRC0300
subject: Enveloppe du bâtiment
valueUri: urn:ircsubjects:IRC0300
subject: temperature gradients
subject: gradient de température
subject: external envelopes
subject: enveloppe (bâtiment)
subject: calculations
subject: méthode de calcul

description: The purpose of this Digest is to show how the thermal gradient can be determined and to indicate why this knowledge is important and how it may be used by building designers.
DÉTERMINATIONS DE L'ABAISSEMENT CRYOSCOPIQUE DE L'HÉMOLYMPHE AVANT ET APRÈS ABLATION DES PÉDONCULES OCULAIRES CHEZ LE CRUSTACÉ BRACHYOURE ERIOCHEIR SINENSIS H. MILNE-EDWARDS
Creators: name: DE LEERSNYDER, Monique
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: During the same intermoult cycle removal of the eyestalks does not affect osmotic concentration in blood of Eriocheir sinensis.
Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms
Creators: name: Tie, Jian Ke
name: Stafford, Darrel W.
name: Jin, Da Yun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Vitamin K epoxide reductase (VKOR) is essential for the production of reduced vitamin K that is required for modification of vitamin K-dependent proteins. Three- and four-transmembrane domain (TMD) topology models have been proposed for VKOR. They are based on in vitro glycosylation mapping of the human enzyme and the crystal structure of a bacterial (Synechococcus) homologue, respectively. These two models place the functionally disputed conserved loop cysteines, Cys-43 and Cys-51, on different sides of the endoplasmic reticulum (ER) membrane. In this study, we fused green fluorescent protein to the N or C terminus of human VKOR, expressed these fusions in HEK293 cells, and examined their topologies by fluorescence protease protection assays. Our results show that the N terminus of VKOR resides in the ER lumen, whereas its C terminus is in the cytoplasm. Selective modification of cysteines by polyethylene glycol maleimide confirms the cytoplasmic location of the conserved loop cysteines. Both results support a three-TMD model of VKOR. Interestingly, human VKOR can be changed to a four-TMD molecule by mutating the charged residues flanking the first TMD. Cell-based activity assays show that this four-TMD molecule is fully active. Furthermore, the conserved loop cysteines, which are essential for intramolecular electron transfer in the bacterial VKOR homologue, are not required for human VKOR whether they are located in the cytoplasm (three-TMD molecule) or the ER lumen (four-TMD molecule). Our results confirm that human VKOR is a three-TMD protein. Moreover, the conserved loop cysteines apparently play different roles in human VKOR and in its bacterial homologues.
CCS: It's not Fair! Fair Schedulers cannot be implemented in CCS-like languages even under progress and certain fairness assumptions
Creators: name: van Glabbeek, Rob
name: Höfner, Peter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: F.1.2; F.3.2

description: In the process algebra community it is sometimes suggested that, on some level of abstraction, any distributed system can be modelled in standard process-algebraic specification formalisms like CCS. This sentiment is strengthened by results testifying that CCS, like many similar formalisms, is Turing powerful and provides a mechanism for interaction. This paper counters that sentiment by presenting a simple fair scheduler---one that in suitable variations occurs in many distributed systems---of which no implementation can be expressed in CCS, unless CCS is enriched with a fairness assumption. Since Dekker's and Peterson's mutual exclusion protocols implement fair schedulers, it follows that these protocols cannot be rendered correctly in CCS without imposing a fairness assumption. Peterson expressed this algorithm correctly in pseudocode without resorting to a fairness assumption, so it furthermore follows that CCS lacks the expressive power to accurately capture such pseudocode.
Fishes from the hydrothermal vents and cold seeps - An update
Creators: name: BISCOITO, Manuel
name: SEGONZAC, Michel
name: ALMEIDA, Armando J.
name: DESBRUYÈRES, Daniel
name: GEISTDOERFER, Patrick
name: TURNIPSEED, Mary
name: VAN DOVER, Cindy
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract
(3952) Angus McLeod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Study of $ψ(3770)$ decaying to Baryon anti-Baryon Pairs
Creators: name: Xia, Li-Gang
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: To study the decays of $ψ(3770)$ going to baryon anti-baryon pairs ($B\bar{B}$), all available experiments of measuring the cross sections of $e^+e^- \to B\bar{B}$ at center-of-mass energy ranging from 3.0 GeV to 3.9 GeV are combined. To relate the baryon octets, a model based on the SU(3) flavor symmetry is used and the SU(3) breaking effects are also considered. Assuming the elctric and magnetic form factors are equal ($|G_E|=|G_M|$), a global fit including the interference between the QED process and the resonant process is performed. The branching fraction of $ψ(3770) \to B\bar{B}$ is determined to be $(2.4\pm0.8\pm0.3)\times10^{-5}$, $(1.7\pm0.6\pm0.1)\times10^{-5}$, $(4.5\pm0.9\pm0.1)\times10^{-5}$, $(4.5\pm0.9\pm0.1)\times10^{-5}$, $(2.0\pm0.7\pm0.1)\times10^{-5}$, and $(2.0\pm0.7\pm0.1)\times10^{-5}$ for $B=p, Λ, Σ^+, Σ^0, Ξ^-$ and $Ξ^0$, respectively, where the first uncertainty is from the global fit and the second uncertainty is the systematic uncertainty due to the assumption $|G_E|=|G_M|$. They are at least one order of magnitude larger than a simple scaling of the branching fraction of $J/ψ\to B\bar{B}$.
description: version accepted by Physics Letters B, revised, discussed added, references added
LES POTENTIALITÉS GERMINALES INTRAGONADIQUES D'ASTERINA GIBBOSA P.
Creators: name: BRUSLÉ, Jacques
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: Study about 100 genital glands of Asterina gibbosa, with ultrastructural control in 25 of which, shows that a double germinal, ovogonial and spermatogonia! stock is present in every gonad.
Ovogonial cells present in gonads corresponding to different genital patterns, are interesting for normal sex-reversal interpretation and useful for understanding about ovogenetic inductions from experimental transplantations or organotypic cultures.
Morphogenetic potentialities from this cells, in situ, present wide variations, from one sexual race to another.
(3947) Thomas Steven Stark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
Creators: name: Reardon, Joyce T.
name: Lindsey-Boltz, Laura A.
name: Wold, Marc S.
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Replication protein A (RPA) plays essential roles in DNA metabolism, including replication, checkpoint, and repair. Recently, we described an in vitro system in which the phosphorylation of human Chk1 kinase by ATR (ataxia telangiectasia mutated and Rad3-related) is dependent on RPA bound to single-stranded DNA. Here, we report that phosphorylation of other ATR targets, p53 and Rad17, has the same requirements and that RPA is also phosphorylated in this system. At high p53 or Rad17 concentrations, RPA phosphorylation is inhibited and, in this system, RPA with phosphomimetic mutations cannot support ATR kinase function, whereas a non-phosphorylatable RPA mutant exhibits full activity. Phosphorylation of these ATR substrates depends on the recruitment of ATR and the substrates by RPA to the RPA-ssDNA complex. Finally, mutant RPAs lacking checkpoint function exhibit essentially normal activity in nucleotide excision repair, revealing RPA separation of function for checkpoint and excision repair.
(3948) William George Stark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Two-photon interference from a quantum dot--microcavity: Persistent pure-dephasing and suppression of time-jitter
Creators: name: Unsleber, Sebastian
name: McCutcheon, Dara P. S.
name: Dambach, Michael
name: Lermer, Matthias
name: Gregersen, Niels
name: Höfling, Sven
name: Mørk, Jesper
name: Schneider, Christian
name: Kamp, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate the emission of highly indistinguishable photons from a quasi-resonantly pumped coupled quantum dot--microcavity system operating in the regime of cavity quantum electrodynamics. Changing the sample temperature allows us to vary the quantum dot--cavity detuning, and on spectral resonance we observe a three-fold improvement in the Hong--Ou--Mandel interference visibility, reaching values in excess of 80\%. Our measurements off-resonance allow us to investigate varying Purcell enhancements, and to probe the dephasing environment at different temperatures and energy scales. By comparison with our microscopic model, we are able to identify pure-dephasing and not time-jitter as the dominating source of imperfections in our system.
description: Close to published version
Sensitivity to Z-prime and non-standard neutrino interactions from ultra-low threshold neutrino-nucleus coherent scattering
Creators: name: Dutta, Bhaskar
name: Mahapatra, Rupak
name: Strigari, Louis E.
name: Walker, Joel W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss prospects for probing Z-prime and non-standard neutrino interactions using neutrino-nucleus coherent scattering with ultra-low energy (~ 10 eV) threshold Si and Ge detectors. The analysis is performed in the context of a specific and contemporary reactor-based experimental proposal, developed in cooperation with the Nuclear Science Center at Texas A&M University, and referencing available technology based upon economical and scalable detector arrays. For expected exposures, we show that sensitivity to the Z-prime mass is on the order of several TeV, and is complementary to the LHC search with low mass detectors in the near term. This technology is also shown to provide sensitivity to the neutrino magnetic moment, at a level that surpasses terrestrial limits, and is competitive with more stringent astrophysical bounds. We demonstrate the benefits of combining silicon and germanium detectors for distinguishing between classes of models of new physics, and for suppressing correlated systematic uncertainties.
description: As published in PRD; 13 pages, 7 figures
FEDORA Policy brief - "A handbook from the FEDORA project: Pathways for future-oriented science education"- Deliverable 6.6
Creators: name: Conti, Francesca
name: Troncoso, Andrea
name: Tola, Elisabetta
name: Chen, Jessica
name: Erduran, Sibel
name: Laherto, Antti
name: Tasquier, Giulia
name: Barelli, Eleonora
name: Pucetaite, Raminta
name: Rasa, Tapio
name: Levrini, Olivia
Publisher: name: Zenodo
Year: 2023
Subjects: future-oriented science education
recommendations
frameworks
science education

description: Deliverable 6.6 “FEDORA Policy Brief” presents the process steps that led to creating the Policy brief that communicates the project’s main results and recommendations. The Policy brief has the structure and the form of “A handbook from the FEDORA project” with the Title: Pathways for future-oriented science education. It included, as well as the recommendations, a brief description of the research process and results on which the recommendations are based. Building upon the Policy Brief n. 1 and the results from WP1, WP2 and WP3 extracted from the final reports (FR1, FR2, FR3) (D1.2, D2.5, D3.3), it was revised based on the results of the Delphi study (T5.3). This version was disseminated at the final conference in Brussels (M33). This document is the sixth deliverable of Work Package 6, “Communication, Dissemination and Exploitation”, led by formicablu.
LES PÉRACARIDES DE L'HYPONEUSTON NOCTURNE DU GOLFE DE MARSEILLE
Creators: name: CHAMPALBERT, Gisèle
name: MACQUART-MOULIN, Claude
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1970

description: An important stratification of the bentho-planctonic Peracarida takes place in the first metre of water, just beneath the sea-surface. A number of species among Mysidacea, Cumacea, Amphipoda and Isopoda have a marked tendency to remain in the first ten centimetres during their night migration. Most of them are species which move upward quickly and temporarily and do not visit the middle layers.
Another group of species, especially among Mysidacea and Amphipoda, are regularly distributed in the whole surface layer, sometimes avoiding the part close to the surface; these are generally species the population density of which is practically the same in the whole water-mass.
title: Le béton
Creators: name: Hutcheon, N. B.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1962
Subjects: subject: Concrete
valueUri: urn:ircsubjects:IRC0740
subject: Béton
valueUri: urn:ircsubjects:IRC0740
subject: concrete (materials)
subject: béton (materiau)
subject: concrete mix design
subject: dosage du béton
subject: setting
subject: prise (hydratation)
subject: expansion contraction
subject: dilatation contraction
subject: durability
subject: durabilité
subject: lightweight concrete
subject: béton leger

description: Ce Digeste donne une idée de la nature générale du béton et de ses propriétés les plus importantes.
New alien Molluscs in the Mediterranean Sea
Creators: name: ÖZTÜRK, Bilal
name: RECEVIK, Murat
name: GEYRAN, Kemal
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: The present work deals with alien molluscs recorded at three stations along the Levantine coast of Turkey between the years 2010 and 2014. Out of 14 identified species, Lodderia novemcarinata, Eratoena sulcifera, Zafra obesula and Zafra pumila are new records for the Mediterranean Sea, whereas the other species, i. e., Finella pupoides, Cerithiopsis pulvis, Cerithiopsis tenthrenois, Rissoina ambigua, Rissoina bertholeti, Pseudorhaphitoma iodolabiata, Pyrgulina maiae, Cingulina isseli, Pyrunculus fourierii and Septifer cumingii, are alien molluscs previously reported from the area. In the investigated material have been also encountered two rarely distributed gastropod species: Colubraria reticulata and Vexillum hypatiae. The present study deals with the new record alien species, and herein are provided some data on the taxonomy, ecology and distribution of the species, with their colour photographs. The study also includes the photographs of Colubraria reticulata and Vexillum hypatiae.
Integrated Inference and Learning of Neural Factors in Structural Support Vector Machines
Creators: name: Houthooft, Rein
name: De Turck, Filip
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Tackling pattern recognition problems in areas such as computer vision, bioinformatics, speech or text recognition is often done best by taking into account task-specific statistical relations between output variables. In structured prediction, this internal structure is used to predict multiple outputs simultaneously, leading to more accurate and coherent predictions. Structural support vector machines (SSVMs) are nonprobabilistic models that optimize a joint input-output function through margin-based learning. Because SSVMs generally disregard the interplay between unary and interaction factors during the training phase, final parameters are suboptimal. Moreover, its factors are often restricted to linear combinations of input features, limiting its generalization power. To improve prediction accuracy, this paper proposes: (i) Joint inference and learning by integration of back-propagation and loss-augmented inference in SSVM subgradient descent; (ii) Extending SSVM factors to neural networks that form highly nonlinear functions of input features. Image segmentation benchmark results demonstrate improvements over conventional SSVM training methods in terms of accuracy, highlighting the feasibility of end-to-end SSVM training with neural factors.
The Limiting Speed of the Bacterial Flagellar Motor
Creators: name: Nirody, Jasmine A.
name: Berry, Richard M.
name: Oster, George
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Recent experiments on the bacterial flagellar motor have shown that the structure of this nanomachine, which drives locomotion in a wide range of bacterial species, is more dynamic than previously believed. Specifically, the number of active torque-generating units (stators) was shown to vary across applied loads. This finding invalidates the experimental evidence reporting that limiting (zero-torque) speed is independent of the number of active stators. Here, we propose that, contrary to previous assumptions, the maximum speed of the motor is not universal, but rather increases as additional torque-generators are recruited. This result arises from our assumption that stators disengage from the motor for a significant portion of their mechanochemical cycles at low loads. We show that this assumption is consistent with current experimental evidence and consolidate our predictions with arguments that a processive motor must have a high duty ratio at high loads.
description: 8 pages, 3 figures (main text); 7 pages, 3 figures (supplementary)
title: Control of condensation in curling rinks
Creators: name: Handegord, G. O.
name: Crocker, C. R.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1962
Subjects: subject: curling rinks
subject: salle de curling
subject: winter sports resorts
subject: station de sports d'hiver
subject: surface condensation
subject: condensation superficielle
subject: dehumidification
subject: déhumidification (traitement)
subject: ventilation
subject: thermal insulation
subject: isolation thermique
subject: drips
subject: larmier

description: This Digest attempts to outline the principles involved in approaching the problem of dripping in curling rinks, and to discuss some of the methods that might lead to a solution. The analysis suggests that some means of introducing heat into the building is probably the most generally applicable and effective condensation control, particularly in the colder areas in Canada. In conjunction with heating, a roof deck having some thermal insulation value should be used for reasons of heat economy and to provide maximum ceiling surface temperatures. Ceiling finishes having water- absorbing characteristics offer considerable advantages over finishes incapable of taking up moisture. Wood roof decking is an ideal ceiling finish as it not only provides thermal insulation but is also capable of absorbing water.