title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð»ÐµÑÐµÐ±Ð½Ð¾-Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð½Ð°Ð¿Ð¸ÑÐºÐ° Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development and experimental substantiation of the effectiveness of the therapeutic and prophylactic properties of a herbal drink with the addition of fucoidan
Creators: name: ÐÐ¸Ð½ÑÐµÐ½ÐºÐ¾, Ð®Ð»Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð»ÐµÑÐµÐ±Ð½Ð¾-Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ
Ð½Ð°Ð¿Ð¸ÑÐ¾Ðº Ð½Ð° ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¾ÑÐ½Ð¾Ð²Ðµ
ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½
Ð±ÑÑÑÐµ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»Ð¸
ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð¼Ð¾Ð´ÐµÐ»Ð¸
Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²ÑÐ¹ ÑÑÑÐµÐºÑ
therapeutic and preventive nutrition
plant-based drink
fucoidan
brown algae
experimental models
anti-tumor effect

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð»ÐµÑÐµÐ±Ð½Ð¾-Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð½Ð°Ð¿Ð¸ÑÐºÐ° Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð°Â». Ð Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·ÑÑÐµÐ½Ñ Ð»ÐµÑÐµÐ±Ð½Ð¾-Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ Fucus Vesiculosus Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ñ in vivo Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½ÑÐ¹ Ð½Ð°Ð¿Ð¸ÑÐ¾Ðº Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð°. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ F. Vesiculosus Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÐµÑÐ¾ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ F. Vesiculosus Ð² Ð´Ð¾Ð·Ðµ 10 Ð¼Ð³/ÐºÐ³ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ ÑÐ¼ÐµÑÐµÐ½Ð½ÑÐ¹ Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÑÑÑÐ¸Ð¹ ÑÑÑÐµÐºÑ Ð½Ð° ÑÐ¾ÑÑ ÑÐ¾Ð»Ð¸Ð´Ð½Ð¾Ð¹ Ð°Ð´ÐµÐ½Ð¾ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ Ð­ÑÐ»Ð¸ÑÐ° Ñ Ð¼ÑÑÐµÐ¹ Ð»Ð¸Ð½Ð¸Ð¸ BALB/c Ð¸ ÑÐ¿Ð¾Ð½ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ HER2 Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÐ°ÐºÐ° Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ Ñ Ð¼ÑÑÐµÐ¹ Ð»Ð¸Ð½Ð¸Ð¸ FVB/N, ÑÑÐ°Ð½ÑÐ³ÐµÐ½Ð½ÑÑ Ð¿Ð¾ Ð¾Ð½ÐºÐ¾Ð³ÐµÐ½Ñ HER2. ÐÑÐ¸ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ð¸ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±Ð·Ð¾ÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ Ð±Ð°Ð·Ñ Ð´Ð°Ð½Ð½ÑÑ eLibrary, PubChem, PubMed. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð°ÐºÐµÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Microsoft Excel, GraphPad Prism Ð²ÐµÑÑÐ¸Ð¸ 8.0. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ in vivo Ð±ÑÐ»Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÐµÑÐµÐ¿ÑÑÑÐ° Ð¸ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ñ Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ° - ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð½Ð°Ð¿Ð¸ÑÐºÐ° Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ F. Vesiculosus, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð°Ñ Ð¾ÑÐµÐ½ÐºÐ° ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÑÐ¾Ð´ÑÐºÑÐ° Ð¿Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÑÐ¼ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ (ÐÐÐÐ¤ÐÐ½Ð, ÐÐÐÐ, Proteus, S.aureus, Salmonella), Ð¾ÑÐ³Ð°Ð½Ð¾Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¸ ÑÐ¸Ð·Ð¸ÐºÐ¾-ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÑÐ¼, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ°ÑÑÑÐ¸ÑÐ°Ð½Ð° ÐµÐ³Ð¾ Ð¿Ð¸ÑÐµÐ²Ð°Ñ Ð¸ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐµÐ½Ð½Ð¾ÑÑÑ. ÐÑÐ¸ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ð¼ Ð°Ð½Ð°Ð»Ð¸Ð·Ðµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ Ð½Ð°Ð¿Ð¸ÑÐºÐ° Ð½Ð° ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¾ÑÐ½Ð¾Ð²Ðµ Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¾Ð½ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸ÑÐ¼ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ ÑÑÐ°Ð½Ð´Ð°ÑÑÐ° Ð¢Ð  Ð¢Ð¡ 021/2011 Ð¸ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸ÑÐ¼ ÐÐÐ¡Ð¢ Ð Â  70650-2023 Â«ÐÐ°Ð¿Ð¸ÑÐºÐ¸ Ð½Ð° ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¾ÑÐ½Ð¾Ð²Ðµ (Ð¸Ð· Ð·ÐµÑÐ½Ð°, Ð¾ÑÐµÑÐ¾Ð², ÐºÐ¾ÐºÐ¾ÑÐ°). ÐÐ±ÑÐ¸Ðµ ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÑÐ»Ð¾Ð²Ð¸ÑÂ». ÐÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ð¹ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÐ°ÑÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð½Ð°Ð¿Ð¸ÑÐºÐ° Ñ Ð´Ð¾Ð±Ð°Ð²Ð»ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð°, Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑÐµÐ³Ð¾ Ð»ÐµÑÐµÐ±Ð½Ð¾-Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°Ð¼Ð¸. ÐÑÐ¾Ð´ÑÐºÑÐ¸Ñ Ð±ÑÐ´ÐµÑ ÑÐ´Ð¾Ð²Ð»ÐµÑÐ²Ð¾ÑÑÑÑ Ð¿Ð¾ÑÑÐµÐ±Ð½Ð¾ÑÑÑ Ð² Ð²Ð¾ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ð¸ Ð´Ð½ÐµÐ²Ð½Ð¾Ð³Ð¾ ÑÐ°ÑÐ¸Ð¾Ð½Ð° Ð¿Ð¸ÑÐµÐ²ÑÐ¼Ð¸ Ð²Ð¾Ð»Ð¾ÐºÐ½Ð°Ð¼Ð¸ Ð¸ Ð²Ð¸ÑÐ°Ð¼Ð¸Ð½Ð°Ð¼Ð¸, Ð¸Ð¼ÐµÑÑ Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÑÐµÐºÑ Ð·Ð° ÑÑÐµÑ Ð½Ð°Ð»Ð¸ÑÐ¸Ñ ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð½Ð° Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ³Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÑÑÐºÐ¾Ð¸Ð´Ð°Ð½Ð° Ð±ÑÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ Fucus Vesiculosus.
description: Topic of the final qualifying work is Â«Development and experimental substantia-tion of the effectiveness of the therapeutic and prophylactic properties of a herbal drink with the addition of fucoidanÂ». In the final qualifying were studied in vivo experiments and a herbal drink with the addition of fucoidan was developed. As a result of experimental studies, it was shown that oral administration of fucoidan from the brown algae F. Vesiculosus at a dose of 10 mg/kg has a moderate inhibitory effect on the growth of solid Ehrlich ade-nocarcinoma in BALB/c mice and spontaneous HER2 positive breast cancer glands in FVB/N mice transgenic for the HER2 oncogene. The databases eLibrary, PubChem, PubMed were used to perform the literary review. Statistical processing of experi-mental data was carried out using the Microsoft Excel software package, GraphPad Prism version 8.0. Based on the in vivo studies obtained, a formulation and manufacturing technology for a new product was developed - a herbal drink with the addition of fucoidan from brown algae F. Vesiculosus, a comprehensive assessment of the product quality was carried out in terms of safety indicators (KMAFAnM, coliform, Proteus, S. aureus, Salmonella), organoleptic and physical and chemical indicators, and also calculated its nutritional and energy value. A comprehensive analysis of the developed plant-based drink with the addition of fucoidan showed that it complies with the safety requirements of the TR CU 021/2011 standard and the requirements of GOST R 70650-2023 âPlant-based drinks (from grains, nuts, coconut). General technical conditions". A marketing strategy for the development of a herbal drink with the addition of fucoidan, which has therapeutic and prophylactic properties, was developed. The products will satisfy the need to replenish the daily diet with dietary fiber and vita-mins, and have a preventive effect due to the presence of fucoidan from brown algae. The obtained experimental results indicate the importance for further study fucoidan properties in the brown algae Fucus Vesiculosus.