cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Medium-Term Variability of the Human Serum Metabolome in the Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: Yu, Bing
name: Zheng, Yan
name: Alexander, Danny
name: Boerwinkle, Eric
name: Couper, David J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Metabolomics is a systems biology tool providing small molecule signatures of disease etiology. In order to estimate the biologic variability of the human serum metabolome, this study calculated intraclass correlation coefficients (ICCs) for 178 stably-detected metabolites measured by untargeted chromatography/mass spectrometry. We studied a subsample of 60 participants (57% males, 70% Caucasians, aged 73.77±5.3 years) in the Atherosclerosis Risk in Communities (ARIC) Study who provided two fasting serum samples 4–6 weeks apart. The median ICC across all metabolites was 0.60, and 82% of metabolites had at least fair variability (i.e., ICC>= 0.40). There was variation in the medium-term variability among metabolites, with those in the pathways of amino acid and lipid metabolism showing relatively high ICCs, and those in the carbohydrate pathway showing relatively low ICCs. The results of this study provide a valuable resource for future study design and outcome interpretation of mass spectrometry-based metabolomic studies in epidemiology.
(401037) MISTAKE MISTAKE
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A neural network multi-task learning approach to biomedical named entity recognition
Creators: name: Crichton, Gamal
name: Pyysalo, S
name: Chiu, B
name: Korhonen, Anna-Leena
Publisher: name: Apollo - University of Cambridge Repository
Year: 2017
Subjects: multi-task learning
convolutional neural networks
named entity recognition
biomedical text mining

description: $\textbf{Background}$ Named Entity Recognition (NER) is a key task in biomedical text mining. Accurate NER systems require task-specific, manually-annotated datasets, which are expensive to develop and thus limited in size. Since such datasets contain related but different information, an interesting question is whether it might be possible to use them together to improve NER performance. To investigate this, we develop supervised, multi-task, convolutional neural network models and apply them to a large number of varied existing biomedical named entity datasets. Additionally, we investigated the effect of dataset size on performance in both single- and multi-task settings. $\textbf{Results}$ We present a single-task model for NER, a Multi-output multi-task model and a Dependent multi-task model. We apply the three models to 15 biomedical datasets containing multiple named entities including Anatomy, Chemical, Disease, Gene/Protein and Species. Each dataset represent a task. The results from the single-task model and the multi-task models are then compared for evidence of benefits from Multi-task Learning. With the Multi-output multi-task model we observed an average F-score improvement of 0.8% when compared to the single-task model from an average baseline of 78.4%. Although there was a significant drop in performance on one dataset, performance improves significantly for five datasets by up to 6.3%. For the Dependent multi-task model we observed an average improvement of 0.4% when compared to the single-task model. There were no significant drops in performance on any dataset, and performance improves significantly for six datasets by up to 1.1%. The dataset size experiments found that as dataset size decreased, the multi-output model’s performance increased compared to the single-task model’s. Using 50, 25 and 10% of the training data resulted in an average drop of approximately 3.4, 8 and 16.7% respectively for the single-task model but approximately 0.2, 3.0 and 9.8% for the multi-task model. $\textbf{Conclusions}$ Our results show that, on average, the multi-task models produced better NER results than the single-task models trained on a single NER dataset. We also found that Multi-task Learning is beneficial for small datasets. Across the various settings the improvements are significant, demonstrating the benefit of Multi-task Learning for this task.
description: This work was supported by Medical Research Council [grant number MR/M013049/1] and the Cambridge Commonwealth, European and International Trust.
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells
Creators: name: Kamholz, John
name: Fulkerson, Patricia C.
name: Cox, Adrienne D.
name: Huang, Yuan
name: Reed, Erin
name: Ratner, Nancy
name: Rangwala, Fatima
name: Ling, Bo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The neurofibromatosis type 1 tumor suppressor protein neurofibromin, is a GTPase activating protein for H-, N-, K-, R-Ras and TC21/R-Ras2 proteins. We demonstrate that Schwann cells derived from Nf1-null mice have enhanced chemokinetic and chemotactic migration in comparison to wild-type controls. Surprisingly, this migratory phenotype is not inhibited by a farnesyltransferase inhibitor or dominant-negative (dn) (N17)H-Ras (which inhibits H-, N-, and K-Ras activation). We postulated that increased activity of R-Ras and/or TC21/R-Ras2, due to loss of Nf1, contributes to increased migration. Mouse Schwann cells (MSCs) express R-Ras and TC21/R-Ras2 and their specific guanine exchange factors, C3G and AND-34. Infection of Nf1-null MSCs with a dn(43N)R-Ras adenovirus (to inhibit both R-Ras and TC21/R-Ras2 activation) decreases migration by approximately 50%. Conversely, expression of activated (72L)TC21/R-Ras2, but not activated (38V)R-Ras, increases migration, suggesting a role of TC21/R-Ras2 activation in the migration of neurofibromin-deficient Schwann cells. TC21/R-Ras2 preferentially couples to the phosphatidylinositol 3-kinase (PI3-kinase) and MAP kinase pathways. Treatment with a PI3-kinase or MAP kinase inhibitor reduces Nf1-null Schwann cell migration, implicating these TC21 effectors in Schwann cell migration. These data reveal a key role for neurofibromin regulation of TC21/R-Ras2 in Schwann cells, a cell type critical to NF1 tumor pathogenesis.
First records of three Paraprionospio species (Polychaeta: Spionidae) from Indian waters
Creators: name: YOKOYAMA, Hisashi
name: SUKUMARAN, Soniya
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The spionid polychaete Paraprionospio pinnata (Ehlers, 1901) has been widely reported from Indian waters. We examined 47 Paraprionospio specimens collected from the west and northwest coast of India, and identified them as Paraprionospio cordifolia Yokoyama, 2007, Paraprionospio cristata Zhou, Yokoyama and Li, 2008, and Paraprionospio patiens Yokoyama, 2007, which are new to the fauna of India. The present study suggests that Paraprionospio species inhabiting Indian waters have been misidentified as P. pinnata and that P. cordifolia, P. cristata, and P. patiens are wide- ly distributed in the Far East and south Asia.
An overview of species introduction and invasion processes in marine and coastal lagoon habitats
Creators: name: BOUDOURESQUE, Charles F.
name: VERLAQUE, Marc
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The species introduction process involves a donor region, a vector, a corridor, a recipient region, a candidate species and a variety of filters that hinder the process. All these parameters are of importance for understanding the success or the failure of a non-native species. Some characteristics of the recipient area, such as low species diversity, disturbances and climate warming, which are often said to facilitate the introduction process in the terrestrial realm, may be of far lesser importance in the marine environment. In contrast, the role of the vector and of the corridor might have been underestimated.
Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion
Creators: name: Arora, P.
name: Cuevas, B. D.
name: Johnson, G. L.
name: Trejo, J.
name: Russo, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Hyperactivation of ErbB signaling is implicated in metastatic breast cancer. However, the mechanisms that cause dysregulated ErbB signaling and promote breast carcinoma cell invasion remain poorly understood. One pathway leading to ErbB activation that remains unexplored in breast carcinoma cell invasion involves transactivation by G-protein-coupled receptors (GPCRs). Protease-activated receptor-1 (PAR1), a GPCR activated by extracellular proteases, is overexpressed in invasive breast cancer. PAR1 is also proposed to function in breast cancer invasion and metastasis, but how PAR1 contributes to these processes is not known. In this study, we report that proteolytic activation of PAR1 by thrombin induces persistent transactivation of EGFR and ErbB2/HER2 in invasive breast carcinoma, but not in normal mammary epithelial cells. PAR1-stimulated EGFR and ErbB2 transactivation leads to prolonged extracellular signal-regulated kinase-1 and −2 signaling and promotes breast carcinoma cell invasion. We also show that PAR1 signaling through Gαi/o and metalloprotease activity is critical for ErbB transactivation and cellular invasion. Finally, we demonstrate that PAR1 expression in invasive breast carcinoma is essential for tumor growth in vivo assessed by mammary fat pad xenografts. These studies reveal a critical role for PAR1, a receptor activated by tumor-generated proteases, in hyperactivation of ErbB signaling that promotes breast carcinoma cell invasion.
(401036) George Lewis Shiell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Recognizing a relatively hyperbolic group by its Dehn fillings
Creators: name: Dahmani, François
name: Guirardel, Vincent
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: Dehn fillings for relatively hyperbolic groups generalize the topological Dehn surgery on a non-compact hyperbolic $3$-manifold such as a hyperbolic knot complement. We prove a rigidity result saying that if two non-elementary relatively hyperbolic groups without suitable splittings have sufficiently many isomorphic Dehn fillings, then these groups are in fact isomorphic. Our main application is a solution to the isomorphism problem in the class of non-elementary relatively hyperbolic groups with residually finite parabolic groups and with no suitable splittings.
description: Minor modification (including typesetting). 56 pages
Exploring scenario guided pathways for food assistance in Tuscany
Creators: name: Galli, Francesca
name: Arcuri, Sabrina
name: Bartolini, Fabio
name: Vervoort, Joost
name: Brunori, Gianluca
Publisher: name: Bio-based and Applied Economics
Year: 2017

description: A growing number of people in high income countries, also from the segments of population once considered secure, seek food assistance. Diverse food aid initiatives and practices are developed by a range of actors to tackle food poverty; alongside traditional difficulties, new challenges emerge from welfare expenditure cuts, the reorganization of EU Funds for the Most Deprived (FEAD) and from the spreading of surplus food recovery practices by private companies. Based on a preliminary analysis on food assistance practices in Tuscany (Italy), it emerged that operators involved in food assistance activities are reflecting upon future developments: how is food assistance re-thinking its role to deal with the challenges posed by the current context of change? This work adopts a participatory scenario approach to examine pathways that can be considered robust under uncertainties in the planning context of food assistance. We combine the strengths of back-casted planning, which develops desirable pathways for the future, and explorative scenarios that describe plausible future contexts. Results comprise the definition of shared priority themes and plans tested across a set of downscaled scenarios. The methodology provides a promising learning tool to engage with stakeholders and foster a creative future oriented thinking approach to food assistance system’s vulnerability and resilience.
description: Bio-based and Applied Economics, Vol 5 No 3 (2016)
Supplementary Information from Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers.
Creators: name: B. N. J. Watson
name: R. A. Easingwood
name: B. Tong
name: M. Wolf
name: G. P. C. Salmond
name: R. H. J. Staals
name: M. Bostina
name: P. C. Fineran
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Supplementary Figures S1-S4 and Supplementary Tables S1-S4
Accessing electronic correlations by half-cycle pulses and time-resolved spectroscopy
Creators: name: Pavlyukh, Y.
name: Berakdar, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Ultrashort non-resonant electromagnetic pulses applied to effective one-electron systems may operate on the electronic state as a position or momentum translation operator. As derived here, extension to many-body correlated systems exposes qualitatively new aspects. For instance, to the lowest order in the electric field intensity the action of the pulse is expressible in terms of the two-body reduced density matrix enabling thus to probe various facets of electronic correlations. As an experimental realization we propose a pump-probe scheme in which after a weak, swift "kick" by the non-resonant pulse the survival probability for remaining in the initial state is measured. This probability we correlate to the two-body reduced density matrix. Since the strength of electronic correlation is bond-length sensitive, measuring the survival probability may allow for a direct insight into the bond-dependent two-body correlation in the ground state. As an illustration, full numerical calculations for two molecular systems are provided and different measures of electronic correlations are analyzed.
description: 4 figures
In vitro and in vivo analysis of B-Myb in basal-like breast cancer
Creators: name: Winkel, S.
name: Parker, J. S.
name: Millikan, R. C.
name: Hoadley, K. A.
name: Perou, C. M.
name: Thorner, A. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: A defining feature of basal-like breast cancer, a breast cancer subtype with poor clinical prognosis, is the high expression of “proliferation signature” genes. We identified B-Myb, a MYB family transcription factor that is often amplified and overexpressed in many tumor types, as being highly expressed in the proliferation signature. However, the roles of B-Myb in disease progression, and its mammary-specific transcriptional targets, are poorly understood. Here, we demonstrated that B-Myb expression is a significant predictor of survival and pathological complete response to neoadjuvant chemotherapy in breast cancer patients. We also identified a significant association between the G/G genotype of a nonsynonymous B-Myb germline variant (rs2070235, S427G) and an increased risk of basal-like breast cancer [OR 2.0, 95% CI (1.1-3.8)]. In immortalized, human mammary epithelial cell lines, but not basal-like tumor lines, cells ectopically expressing wild-type B-Myb or the S427G variant showed increased sensitivity to two DNA topoisomerase IIα inhibitors, but not to other chemotherapeutics. In addition, microarray analyses identified many G2/M genes as being induced in B-Myb overexpressing cells. These results confirm that B-Myb is involved in cell cycle control, and that dysregulation of B-Myb may contribute to increased sensitivity to a specific class of chemotherapeutic agents. These data provide insight into the influence of B-Myb in human breast cancer, which is of potential clinical importance for determining disease risk and for guiding treatment.
The circular economy and agriculture: new opportunities for re-using Phosphorus as fertilizer
Creators: name: Vollaro, Michele
name: Galioto, Francesco
name: Viaggi, Davide
Publisher: name: Bio-based and Applied Economics
Year: 2017

description: The increasing demand of phosphorus (P) worldwide is posing important challenges on the market stability of fertilizers. Extracting more P would not guarantee high P quality and low prices. Globally, only the European Commission, in a recent document about the Circular Economy strategy, has begun to address the challenge of the dependence on phosphate rock. Based on a simple circular economy theoretical framework, this paper proposes an impact analysis of the use of recycled P as a substitute of chemical P fertilizers. Two new technologies applied to retrofit existing wastewater treatment plants (WWTP) are considered: Moving-Bed Bio-Reactors and Struvite Crystallization Modules. The analyses indicate that the introduction of these technologies prove to be economically sustainable for specific levels of inhabitant equivalent (IE) and that the profitability of struvite, as a substitute of chemical P, increases with increasing levels of P fertilizer prices and for increasing sizes of WWTPs.
description: Bio-based and Applied Economics, Vol 5 No 3 (2016)
The political economy of trade-related regulatory policy: environment and global value chain
Creators: name: Olper, Alessandro
Publisher: name: Bio-based and Applied Economics
Year: 2017

description: This paper proposes a selective review of the political and economics literature on non-tariff measures (NTMs), with special emphasis on the so-called behind-the-border measures, such as environmental and food standards. We focus on both theory and existing empirical evidence. The complex issue of international trading rules over domestic regulatory standards, as well as the emerging role of outsourcing and global value chains, is also considered.
description: Bio-based and Applied Economics, Vol 5 No 3 (2016)
The Bryozoan assemblages and their relationship with certain environmental factors along the shallow and subtidal Tunisian coasts
Creators: name: BEN ISMAIL, Dorsaf
name: RABAOUI, Lotfi
name: DIAWARA, Moktar
name: BEN HASSINE, Oum Kalthoum
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: In this study, bryozoan communities were investigated along the Tunisian coastline, using both univariate and multivariate analyses. Seven populations situated at different localities belonging to different geographic sectors, were sampled, and the communities were analysed and compared taking into account different environmental factors. The analysis of similarity (ANOSIM) showed that the population structure of Bryozoans seems to be influenced by "geographic location", "habitat type" and "substratum type" factors. The latter two factors seemed to be linked since each habitat type was characterized by a special type of substratum. The similarity percentage (SIMPER) analysis showed that each analysed community was dominated by some particular species. In fact, some bryozoan species were exclusive to marine sites, while others were exclusive to lagoons. In addition, bryozoan community was qualitatively richer in marine sites than that in lagoons. The species Electra posidoniae, Collarina balzaci and Microporella ciliata were found to be the most contributing to the dissimilarity between the two habitat types. The marine/lagoon discrimination obtained with univariate analyses was also confirmed by multivariate ones i.e. non metrical MDS and Bray-Curtis similarity. In terms of constancy index, the majority of assemblages was dominated by "not very common" species.
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities
Creators: name: Yang, X. Y.
name: Vigil, D.
name: Popescu, N. C.
name: Der, C. J.
name: Guan, M.
name: Lowy, D. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: DLC1, which encodes a Rho GTPase activating protein (Rho-GAP), is a potent tumor suppressor gene that is frequently inactivated in several human cancers. DLC-1 is a multidomain protein that has been shown previously to bind members of the tensin gene family. Here we show that p120Ras-GAP (Ras-GAP; also known as RASA1) interacts and extensively colocalizes with DLC1 in focal adhesions. The binding was mapped to the SH3 domain located in the N-terminus of Ras-GAP and to the RhoGAP catalytic domain, located in the C-terminus of the DLC1. In vitro analyses with purified proteins determined that the isolated Ras-GAP SH3 domain inhibits DLC1 RhoGAP activity, suggesting that Ras-GAP is a negative regulator of DLC1 RhoGAP activity. Consistent with this possibility, we found that ectopic overexpression of Ras-GAP in a Ras-GAP-insensitive tumor line impaired the growth suppressing activity of DLC1 and increased RhoA activity in vivo. Our observations expand the complexity of proteins that regulate DLC1 function and define a novel mechanism of the cross-talk between Ras and Rho GTPases.
Unusual shallow inshore records of Cornish blackfish Schedophilus medusophagus (Stromateoidei: Centrolophidae) from Galician waters (NW Spain)
Creators: name: BAÑÓN, Rafael
name: ALONSO-FERNÁNDEZ, Alexandre
name: QUIGLEY, Declan T.G.
name: MIRANDA, Ana
name: ARRONTE, Juan Carlos
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Three shallow inshore records of Cornish blackfish Schedophilus medusophagus from Galician waters (NW Spain) are reported. S. medusophagus is a relatively rare mesopelagic species in the NE Atlantic. Adult specimens are mainly found in medium-depth waters (300-900 m). Their presence in shallower coastal waters is very unusual. An historical review of North Atlantic shallow inshore records was made. Reproductive and stomach content analyses were investigated and related to two proposed inshore migration hypotheses. Resulting from these investigations, the first description of gametogenesis and gonadal development organization of this species is presented. Ovary development was found to be group-synchronous, with a highly synchronous population of larger follicles. Testicular tissue was found to be lobular type. Since no conclusive evidence was found to support either of the two proposed hypotheses an additional hypothesis related to increasing sea water temperatures was proposed.
Supplementary Information from Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers
Creators: name: B. N. J. Watson
name: R. A. Easingwood
name: B. Tong
name: M. Wolf
name: G. P. C. Salmond
name: R. H. J. Staals
name: M. Bostina
name: P. C. Fineran
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Supplementary Figures S1-S4 and Supplementary Tables S1-S4
Gamma Lines from Majorana Dark Matter
Creators: name: Duerr, Michael
name: Perez, Pavel Fileviez
name: Smirnov, Juri
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss simple models which predict the existence of significant gamma-ray fluxes from dark matter annihilation. In this context the dark matter candidate is a Majorana fermion with velocity-suppressed tree-level annihilation into Standard Model fermions but unsuppressed annihilation into photons. These gamma lines can easily be distinguished from the continuum and provide a possibility to test these models.
description: 6 pages, 4 figures, version to appear in PRD
Supplemental Materials from The unified rule of phyllotaxis explaining both spiral and non-spiral arrangements.
Creators: name: Okabe, Takuya
name: Ishida, Atsushi
name: Yoshimura, Jin
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Biophysics
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Supplementary Text and Supplementary Figures S1-3
Palladin contributes to invasive motility in human breast cancer cells
Creators: name: Goicoechea, S. M.
name: Prentice-Dunn, H.
name: García-Mata, R.
name: Kim, H. J.
name: Bednarski, B.
name: Otey, C. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: SUMMARYCancer metastasis involves multiple steps including detachment of the metastatic cells from neighboring cells, the acquisition of motility and invasion to other tissue. All of these steps require the reorganization of the actin cytoskeleton. In this study, we found that the protein palladin, a molecular scaffold with an important function in actin organization, is expressed at higher overall levels in tumors compared to benign breast tissue, and also significantly higher in four invasive breast cancer cell lines when compared to four non-invasive cell lines. In addition, we found that palladin plays a key role in the formation of podosomes. Podosomes are actin-rich structures that function in adhesion and matrix degradation and have been found in many invasive cell types. Our results show that phorbol ester treatment stimulated the formation of palladin-containing podosomes in invasive, but not in non-invasive cell lines. More importantly, palladin knockdown resulted in decreased podosome formation and a significant reduction in transwell migration and invasive motility. Palladin overexpression induced podosome formation in the non-invasive MCF7 cells, which are otherwise unable to form podosomes, suggesting that palladin plays a critical role in the assembly of podosomes. Overall, these results indicate that palladin overexpression contributes to the invasive behavior of metastatic cells.
(401035) John Shiell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Generalized robust toric ideals
Creators: name: Tatakis, Christos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 14M25, 05E40, 13P25

description: An ideal I is robust if its universal Gröbner basis is a minimal generating set for this ideal. In this paper, we generalize the meaning of robust ideals. An ideal is defined as generalized robust if its universal Gröbner basis is equal to its universal Markov basis. This article consists of two parts. In the first one, we study the generalized robustness on toric ideals of a graph G. We prove that a toric graph ideal is generalized robust if and only if its universal Markov basis is equal to the Graver basis of the ideal. Furthermore, we give a graph theoretical characterization of generalized robust graph ideals, which is based on terms of graph theoretical properties of the circuits of the graph G. In the second part, we go on to describe the general case of toric ideals, in which we prove that a robust toric ideal has a unique minimal system of generators, or in other words, all of its minimal generators are indispensable.
description: 17 pages, 5 figures
Upright Erythropeltidales (Rhodophyta) in Brittany, France and description of a new species, Erythrotrichia longistipitata
Creators: name: WEST, John A.
name: LOISEAUX-DE-GOËR, Susan
name: ZUCARELLO, Giuseppe C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The Erythropeltidales are a ubiquitous group of red algae in the class Compsopogonophyceae. While their presence in the wild is often evident their taxonomy is frequently problematic. We approached the diversity of the group in northern Brittany, France by establishing unialgal cultures to find consistent characters and molecular methods to support the taxonomic conclusions. Erythrotrichia longistipitata sp. nov. is distinguished from other Erythrotrichia species by the elongate basal cell of erect filaments that is about 1.5-2.0 times longer than other intercalary cells. This species is molecularly distinct from all other genetic lineages of Erythrotrichia we have investigated. Erythrotrichia welwitschii is considered an obligate epiphyte of Ralfsia in the field, but in culture it grows well on glass. Monospores have bipolar germination, forming a lobed basal cell and an upper cell that becomes an upright filament. The basal cell in E. welwitschii becomes a multicellular disc from which secondary erect filaments can arise. Porphyrostromium boryanum has flat mono- stromatic upright blades and probable spermatia, carpogonia, and syngamy were observed. The complete sexual life history was not observed. Porphyrostromium ciliare with uniseriate and terete multiseriate upright shoots also produced probable spermatia and carpogonia but again the complete sexual life history was not observed. Observations of sex in the Erythropeltidales have never been completely resolved with the site of meiosis and the ploidy of various stages never fully explained.
Analysing the Evolution of Community-Driven (Sub-)Schemas within Wikidata
Creators: name: Baroncini, Sofia
name: Martorana, Margherita
name: Scrocca, Mario
name: Śmiech, Zuzanna
name: Polleres, Axel
Publisher: name: Zenodo
Year: 2022
Subjects: Ontology Evolution
Empirical Semantics
Domain-specific Communities
Wikidata

description: Supplementary material for the position paper "Analysing the Evolution of Community-Driven (Sub-)Schemas within Wikidata" accepted at the Wikidata Workshop 2022 approach-overview.png - Diagram providing an overview of the approach slides.pdf - Slides of the presentation at the Wikidata Workshop video.mp4 - Pre-recorded video presentation for the Wikidata Workshop
Supplemental Materials from The unified rule of phyllotaxis explaining both spiral and non-spiral arrangements
Creators: name: Okabe, Takuya
name: Ishida, Atsushi
name: Yoshimura, Jin
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Biophysics
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Supplementary Text and Supplementary Figures S1-3
Trace metals in molluscs Patella caerulea (Linnaeus, 1758) from Tunisian North Coasts, Mediterranean Sea
Creators: name: BELKHODJA, Hela
name: MISSAOUI, Hechmi
name: ROMDHANE, Mohamed Salah
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The limpets Patella caerulea was evaluated as possible biomonitor of heavy metal contamination in marine coastal areas. Water samples and specimens of the limpet were sampled seasonally during 2006-2007, from three different stations in the North coasts of Tunisia (Bizerta Channel: CB, La Goulette: LG and Sidi Rais: SR) to measure their accumulated heavy metal concentrations. The concentrations of Fe, Mn, Cu, Cd, Cr, Ni, Al and Pb were determined by ICP- OES methods. In water samples, only 3 metals (Mn, Cu and Al) were detected at different stations while in the limpet all the investigated metals were found. Iron and Aluminium concentrations in soft tissues of P. caerulea were significantly higher (ANOVA, p < 0.05) than the concentration of the other metals in all the stations while the lowest one was cadmium concentration. The order of metal accumulation in the animal at different stations was: Fe >> Al >> Mn - Cu > Ni - Pb > Cr > Cd. The highest mean values of the heavy metals in soft tissues of P. caerulea were found at CB station, for Cd, Cr and Fe. We also noticed at the same station relatively high mean values for Ni, Al and Pb; at LG station, for Mn, Cu and Pb and at SR station for Al.
Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration
Creators: name: Zen, Y.
name: Endo, K.
name: Horikawa, T.
name: Shackleford, J.
name: Kitagawa, N.
name: Pagano, J. S.
name: Yoshizaki, T.
name: Kondo, S.
name: Furukawa, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Tumor metastasis is a complex phenomenon that is the culmination of effects of numerous cellular factors. We have shown that the EBV oncoprotein, latent membrane protein 1 (LMP1), is capable of inducing a wide range of such factors in cell culture, expression of which is also elevated in the LMP1-expressing tumor, nasopharyngeal carcinoma (NPC), a highly invasive neoplasm. Recently, the membrane-crosslinker protein ezrin has been implicated in tumor cell metastasis and malignant progression. In this study, we evaluated the possible role of LMP1 and ezrin in the pathophysiology of NPC. We show that C-terminal phosphorylation of ezrin is increased by expression of LMP1 in nasopharyngeal (NP) cells through a Protein Kinase C (PKC) pathway. LMP1 enhances organization of a ternary complex of CD44, ezrin and F-actin which is a prerequisite for ezrin phosphorylation. In NPC tissues, expression of phosphoezrin and LMP1 is directly correlated. Silencing of endogenously expressed ezrin suppresses LMP1-induced cell motility and invasiveness. Moreover inhibition of ezrin phosphorylation by PKC inhibitor suppresses migration and invasion of NP cells. These data demonstrate that phosphorylation of ezrin and its recruitment to the cell membrane linked to F-actin and CD44 is a process required for LMP1-stimulated cell motility and invasion of NP cells.
(401034) Anthony George Shiell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Ultrasensitive magnetometry using quantum-based sensor technology
Creators: name: Trahms, Lutz
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2020
Subjects: Qantenmagnetometrie
SQUID
OPM

description: Enthalten in PTB-Mitteilungen. Band 130 (2020), Heft 3. ISSN 0030-834X
(401033) Gertrude Minna M Shiell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The question of intrinsic origin of the metal-insulator transition in i-AlPdRe quasicrystal
Creators: name: Delahaye, Julien
name: Berger, Claire
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The icosahedral (i-) AlPdRe is the most resistive quasicrystalline alloy discovered so far. Resistivities ($ρ$) of $1Ωcm$ at 4K and correlated resistance ratios ($RRR = ρ_{4K}/ρ_{300K}$) of more than 200 are observed in polycrystalline samples. These values are two orders of magnitude larger than for the isomorphous i-AlPdMn phase. We discuss here the controversial microscopic origin of the i-AlPdRe alloy electrical specificity. It has been proposed that the high resistivity values are due to extrinsic parameters, such as secondary phases or oxygen contamination. From comprehensive measurements and data from the literature including electronic transport correlated with micro structural and micro chemical analysis, we show that on the contrary there is mounting evidence in support of an origin intrinsic to the i-phase. Similarly to the other quasicrystalline alloys, the electrical resistivity of the i-AlPdRe samples depends critically on minute changes in the structural quality and chemical composition. The low resistivity in i-AlPdRe single-grains compared to polycrystaline samples can be explained by difference in chemical composition, heterogeneity and thermal treatment.
description: 19 pages, 17 figures
Cendrillon
Creators: name: Isouard, Nicolò
Publisher: name: chez Nicolo, auteur, rue des Colonnes, no. 4
Year: 1810

description: Description du matériel pour harmonie : 1 partie de flûte, 1 partie de clarinette I, 1 partie de clarinette II, 1 partie de cor I, 1 partie de cor II, 1 partie de basson I, 1 partie de basson II, 1 partie de serpent
description: musique de Nicolo de Malte ; arrangée en harmonie pour deux clarinettes, deux cors, deux bassons et flûte par F. R. Gebauer
Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma
Creators: name: Brannon, A. R.
name: Chen, S.
name: Rathmell, W. K.
name: Mitchell, C.
name: Espinosa, I.
name: Edwards, L.
name: Pruthi, R.
name: Wright, T. M.
name: Wallen, E.
name: Nusse, R.
name: Van De Rijn, M.
name: Gordan, J. D.
name: Mikels, A. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Inappropriate kinase expression and subsequent promiscuous activity defines the transformation of many solid tumors including renal cell carcinoma (RCC). Thus, the expression of novel tumor-associated kinases has the potential to dramatically shape tumor cell behavior. Further, identifying tumor-associated kinases can lend insight into patterns of tumor growth and characteristics. Here, we report the identification of Ror2, a new tumor-associated kinase in RCC cell lines and primary tumors. Ror2 is an orphan receptor tyrosine kinase with physiological expression normally seen in the embryonic kidney. However, in RCC, Ror2 expression correlated with expression of genes involved at the extracellular matrix, including Twist and matrix metalloprotease-2 (MMP2). Expression of MMP2 in RCC cells was suppressed by Ror2 knockdown, placing Ror2 as a mediator of MMP2 regulation in RCC and a potential regulator of extracellular matrix remodeling. The suppression of Ror2 not only inhibited cell migration, but also inhibited anchorage independent growth in soft agar and growth in an orthotopic xenograft model. These findings suggest a novel pathway of tumor-promoting activity by Ror2 within a subset of renal carcinomas, with significant implications for unraveling the tumorigenesis of RCC.
Synergies (of ESO Facilities) with Space Missions
Creators: name: Sozzetti, Alessandro
Publisher: name: Zenodo
Year: 2022

description: This invited review explores aspects of the synergies provided by ESO’s current and future facilities (ALMA/ELT/VLT/VLTI/La Silla telescopes) with other space observatories (Gaia, JWST, PLATO, Roman observatory, LRIOUV) in the field of exoplanet demographics. The prospects in this field in the next decade are also discussed.
Supplementary Information from Diurnal variation in the production of vocal information about food supports a model of social adjustment in wild songbirds.
Creators: name: F. Hillemann
name: E. F. Cole
name: S. C. Keen
name: B. C. Sheldon
name: D. R. Farine
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Diurnal variation in the production of vocal information about food supports a model of social adjustment in wild songbirds
Differences in phytoplankton accumulation between Mediterranean mussel Mytilus galloprovincialis Lamarck, 1819 and European flat oyster Ostrea edulis Linneaus, 1758 after natural exposure to toxic Dinophysis bloom
Creators: name: SKEJIĆ, Sanda
name: NINČEVIĆ GLADAN, Živana
name: EZGETA-BALIĆ, Daria
name: PEHARDA, Melita
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: In the aim to better understand the dynamics of diarrhetic shellfish poisoning (DSP) contamination in Mali Ston Bay, the most important bivalve aquaculture area in the eastern Adriatic Sea, a field study was carried out to detect differences in phytoplankton cells accumulation in two commercially cultured shellfish species; the mussel Mytilus galloprovincialis Lamarck, 1819 and the oyster Ostrea edulis Linnaeus, 1758. The study was conducted following a bloom of Dinophysis (Ehrenberg, 1839) at the end of March 2010. Analyses of stomach content showed considerable differences in phytoplankton consumption between the two investigated shellfish species. In M. galloprovincialis, a higher number of phytoplankton species was found than in O. edulis. The most pronounced differences were induced by different accumulation and retention of toxic Dinophysis species. The most abundant species in the mussels' stomach content was Dinophysis fortii Pavilard, 1923, as opposed to oysters where D. fortii occurred sporadically and in small numbers. Concentrations of both Dinophysis caudata Saville-Kent, 1881 and Dinophysis rotundata Claparède & Lachmann, 1859 in mussels were very low with percentage contribution ranging from 0-1.0% and 0-1.2%, respectively, in total phytoplankton community, whereas the occurrence of these species in oysters has not been registered at all.
(401032) Alexandrine Ursula Wilhelmine Korn
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo
Creators: name: Lee, C. M.
name: Sanford, C. A.
name: Cowey, C. L.
name: Simon, M. C.
name: Hickey, M. M.
name: Rathmell, W. K.
name: McGuire, C. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Von Hippel-Lindau (VHL) disease is caused by germline mutations in the VHL tumor suppressor gene, with Type 2B missense VHL mutations predisposing to renal cell carcinoma, hemangioblastoma, and pheochromocytoma. Type 2B mutant pVHL is predicted to be defective in hypoxia inducible factor (HIF)-α regulation. Murine embryonic stem (ES) cells in which the endogenous wild-type Vhl gene was replaced with the representative Type 2B VHL hotspot mutation R167Q (Vhl2B/2B) displayed preserved physiologic regulation of both HIF factors with slightly more normoxic dysregulation of HIF-2α. Differentiated Vhl2B/2B-derived teratomas over-expressed the joint HIF targets Vegf and EglN3 but not the HIF-1α-specific target Pfk1 and displayed a growth advantage over Vhl-/--derived teratomas, suggestive of a tight connection between perturbations in the degree and ratio of HIF-1α and HIF-2α stabilization and cell growth. Vhl2B/2B mice displayed mid-gestational embryonic lethality, while adult Vhl2B/+ mice exhibited susceptibility to carcinogen-promoted renal neoplasia compared with wild-type littermates at twelve months. Our experiments support a model in which the representative Type 2B R167Q mutant pVhl produces a unique profile of HIF dysregulation, thereby promoting tissue-specific effects on cell growth, development, and tumor predisposition.
Gametogenic cycle and monthly variations of oocyte size in the invasive cockle Fulvia fragilis (Bivalvia: Cardiidae) from the Bay of Tunis (northern Tunisia, central Mediterranean)
Creators: name: RIFI, Mouna
name: BEN SOUISSI, Jamila
name: ZEKRI, Sami
name: JAAFOURA, Mohamed Habib
name: LE PENNEC, Gaël
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: This is the first study on the gametogenic cycle of the cockle Fulvia fragilis, lessepsian successfully established species throughout the Tunisian coast and especially, in northern areas, such as the Bay of Tunis. 6437 oocytes were measured from 73 specimens of F. fragilis collected from April 2006 to April 2007. The recorded data allowed us to show that F. fragilis had a continuous gonadal activity with significant gametogenic regeneration. Significant differences were found between the mean oocyte diameter for the various stages of sexual maturity (ANOVA, P < 0.05). Throughout the study period, all categories of oocytes (previtellogenic oocyte, vitellogenic oocyte and mature oocyte) were observed during all gametogenesis stages, except during the early stages. This continuous gametogenic production was related to the successive spawns observed. These latter could explain the successful establishment of F. fragilis in its new areas and as a consequence, of its fast geographical expansion, not only in the Tunisian waters, but also, throughout the Mediterranean Sea.