cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Phenobarbital for the management of severe acute alcohol withdrawal (the PHENOMANAL trial): a pilot randomized controlled trial
Creators: name: Filewod, Niall
name: Hwang, Stephen
name: Turner, Christian J.
name: Rizvi, Leena
name: Gray, Sara
name: Klaiman, Michelle
name: Buell, Danielle
name: Ailon, Johnathan
name: Caudarella, Alexander
name: Ginocchio, Galo F.
name: Santos, Marlene
name: Sandhu, Gyan
name: Dewhurst, Norman
name: Sequeira, Kelly
name: Burns, Karen E. A.
Publisher: name: BioMed Central
Year: 2022

description: Background Benzodiazepines are considered first-line treatment for patients experiencing severe acute alcohol withdrawal syndrome (sAAWS). Although several medications have been evaluated as potential adjuvant treatments for sAAWS, barbiturates show particular promise. Objective In the PHENOMANAL trial, we will assess the feasibility of conducting an allocation-concealed, quadruple-blinded, randomized controlled trial (RCT) comparing symptom-triggered benzodiazepine therapy with either a single dose of adjuvant intravenous (IV) phenobarbital (7.5 mg/kg of ideal body weight) or a single dose of matching IV placebo for patients with sAAWS. Methods We will recruit adult patients from the Emergency Department, Intensive Care Unit, or hospital wards with a Clinical Institute of Withdrawal – Adult revised (CIWA-Ar) score of 16 or more after receipt of at least 60 mg of diazepam or equivalent within 16 h of diagnosis of sAAWS, and an anticipated need for hospitalization. We will randomize participants (n=39) in a 2:1 manner to treatment and placebo groups, respectively. The primary objective of the PHENOMANAL pilot trial will be to demonstrate our ability to recruit the desired population over the trial period. As secondary objectives, we will evaluate clinician compliance with the treatment protocols, assess crossover rates from the placebo arm to the treatment arm, and obtain preliminary estimates of treatment effect. All trial participants will be followed for 7 days or until hospital discharge. Relevance The PHENOMANAL trial is novel in investigating a new treatment for a common and understudied condition, repurposing an existing medication for a novel indication, and addressing an important evidence gap. Through conduct of the multidisciplinary pilot trial, we aim to advance methodology in acute care research through the use of a hybrid consent model and inform the design of a large-scale trial. Trial registration ClinicalTrials.gov Registration NCT03586089 ; first registered July 13, 2018.
Supplementary document for Microwave frequency measurement with high-accuracy and wide-bandwidth based on whispering-gallery mode barcode - 5439280.pdf
Creators: name: Wan, Yangyang
name: Fan, Xinyu
name: Xu, Bingxin
name: He, Zuyuan
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Detailed experiment description and more measurement results
Testing for the Existence of Small Nesting Males in a Natural Population of Bluebanded Gobies, Lythrypnus Dalli
Creators: name: Bush, Joseph
Publisher: name: Georgia State University
Year: 2016

description: In protogynous fishes, smaller individuals tend to be female and only the largest individuals are male. In Lythrypnus dalli the small population of mini-males that are found in the wild are typically alternative males that mimic females to gain access to the nest. However, recent work has shown that small juveniles can develop into mini-nesting males in a laboratory setting. We tested whether or not some of the small males in the wild are actually mini-nesting males by comparing the content of the accessory gonadal structure (AGS), a prostate-like gland that is known to have different functions in nesting and mini-males. Over half of the mini-males had AGS contents typical of nesting males as well as larger dorsal fins and longer genital papillae than the alternative males. These findings add to our understanding of the role of the environment in regulating sexual phenotype in L. dalli.
Behavioral Studies of Chemoreception by the Pacific White Shrimp Litopenaeus Vannamei: Testing Attractability and Palatability of Proprietary Chemical Mixtures that Augment Feed Pellets Used in Shrimp Aquaculture
Creators: name: Elsayed, Farida
Publisher: name: Georgia State University
Year: 2016

description: Litopenaeus vannamei or Pacific white shrimp is the most widely farmed crustacean in the world. Shrimp are commonly fed feed containing 30-40% soybean meal or other plant-based feeds that are more economically and environmentally sustainable than animal-based feed. However, plant-based pellets are less palatable and less chemically attractive compared to animal material. Based on that, current research and practice includes the addition of specific marine animal meals in order to enhance palatability and attractability of plant-based shrimp feed. Yet, it is not sustainable or economically achievable to continue relying on marine animal meal. In the herein study, the effect of proprietary chemical mixtures designed by our research group as feed additives was examined based on their attractability and palatability in comparison to krill meal, a highly attractive and palatable supplement for shrimp feed. In palatability assays, total amount of pellets was measured before and after one-hour and three-hour periods of feeding in group-housed animals. In attractability assays, responses of shrimp were measured based on the number of probes and grabs on the source (airstone) of the stimulus being released. Each diet-set used contained different concentrations of krill meal and synthetic chemical mixtures. Results demonstrated these chemical mixtures enhance attractability and palatability of soybean based feed in L. vannamei when compared to krill meal. Furthermore, the addition of a proprietary mixture (= ?premix?) improved responses in the attractability assays when compared to stimuli that did not contain the premix. Overall, results support the hypothesis that synthetic chemical mixtures can improve palatability and attractability of soybean meal based shrimp feed. This work could provide a reference for the development of synthetic chemoattractants and chemopallatants for the aquaculture of shrimp.
Sympathetic And Sensory Innervation And Activation Of Inguinal And Epididymal White Adipose Tissue
Creators: name: Mendez, Jennifer
Publisher: name: Georgia State University
Year: 2016

description: Studies have suggested the possibility that there is sensory (SS) afferent signaling from white adipose tissue (WAT) to the brain, which may play an important role in communication with the brain sympathetic nervous system (SNS) outflow to WAT. Therefore, we tested whether the SNS-SS feedback loop between the subcutaneous inguinal WAT (IWAT) and the epididymal WAT (EWAT) exists. These fat pads were chosen due to 1) their divergent role in manifestation of metabolic disorders with the IWAT being beneficial and the EWAT being detrimental, as well as 2) different lipolytic response to glucoprivic 2-deoxyglucose (2DG). By using retrograde tract tracers Fast Blue (FB) and Fluorogold (FG), we found that the IWAT is more innervated than EWAT by both the SS and SNS ganglia (T13-L3). Surprisingly, we found ~12-17% of double-labeled cells in the SNS and SS ganglia innervating fat depots, implying SNS-SS crosstalk loops between the IWAT and EWAT. Increased neuronal activation by 2DG was observed in the SNS ganglia to both IWAT and EWAT but not in the SS dorsal root ganglia. In addition, 2DG induced lipolysis in both fat pads with greater lipolytic properties in the IWAT as a result of higher density of the SNS-SS fibers. Collectively, our results show neuroanatomical reality of the IWAT and EWAT SNS-SS neural crosstalk with a coordinated control of lipolytic function.
Functional integrated photonic devices incorporating 2D graphene oxide films
Creators: name: Qu, Yang
Publisher: name: Swinburne
Year: 2024

description: All-optical signal processing is a promising technology that is thought to have the potential to overcome the inherent speed and bandwidth limitations of electronic signal processing. On-chip signal generation, which is a crucial part of all-optical signal processing, necessitates the use of integrated nonlinear optical components. However, existing integrated optical platforms all have limitations in their nonlinear optical performance. The aim of this thesis is to improve the linear and nonlinear optical performance of the CMOS compatible existing integrated optical platforms by incorporating them with two-dimensional layered graphene oxide films.
DEVELOP AN APPLICATION THAT CONVERTS VIDEOS INTO SLIDES UTILIZING BACKGROUND ESTIMATION AND FRAME DIFFERENCING IN OPENCV
Creators: name: Primbetov, Abbaz
name: Abdusalomov, Shaxbozbek
name: To'lqinov, Oybek
name: Rahmonova, Mahbuba
name: Pardaboyeva, Mohichexra
Publisher: name: Zenodo
Year: 2024

description: In this paper, we will guide you through the process of creating a user-friendly video-to-slides converter application. The goal is to extract slide images from slide or lecture videos using fundamental frame differencing and background subtraction techniques available in OpenCV. By following the instructions provided, you will be able to develop a straightforward and efficient solution for converting videos into slide images.
title: „Gender in der Schusslinie – Die einen sehen * – Die anderen sehen Rot“: Tagungsbericht zur Veranstaltungsreihe vom 25. Juni bis zum 05. Juli 2018 an der Universität Siegen
Creators: name: Austermann, Julia
name: Fenske, Uta
name: Rädcher, Tatjana
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 68
title: Genders & Sexualities: East Asia & Europe Network (GSN): Bericht zum Auftaktsymposium „Queerying Japan“
Creators: name: Germer, Andrea
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 71
A Comparative Analysis of Nicotinic Acetylcholine Receptor Subunits and Cholinergic Neurons in Nudipleura Molluscs
Creators: name: Tikir, Seydanur
Publisher: name: Georgia State University
Year: 2016

description: Acetylcholine (ACh) and nicotinic acetylcholine receptors (nAChR) play important roles in the transmission of electrical signals in the brain. The diversity of nAChR subunits contributes to differential regulation of signal transmission at synapses. Twenty types of nAChR subunits were previously identified in two gastropod molluscs, Aplysia californica and Lymnaea stagnalis (van Nierop et al., 2006; White et al., 2014). Here, they were identified in six nudipleura molluscs: Flabellina iodinea, Hermissenda crassicornis, Tritonia diomedea, Pleurobranchaea californica, Melibe leonina and Dendronotus iris. In addition, four novel nAChR subunits were predicted with an ortholog-based approach. Bioinformatically determined gene expression levels showed species differences. Whole-mount in situ hybridization using choline acetyltransferase gene probes localized cholinergic neurons in the brains of Dendronotus and Melibe. Investigation and comparison of nAChRs and cholinergic neurons in the brains of these animals will help to understand how neurochemistry relates to the organization and evolution of neural circuitry.
Arenostola phragmitidis
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Arenostola
Arenostola phragmitidis

description: Arenostola phragmitidis (Hübner, 1803) *
 Bionomics. FP: VIII. Hygrophilous species. River valleys.
 Known locality. P: Zhertumsyk.
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
The Genetic Characterization of Locomotive Neural Circuits in Caenorhabditis Elegans
Creators: name: Alcala, Aaron-Jay
Publisher: name: Georgia State University
Year: 2017

description: Cellular networks are required for a variety of processes in complex organisms. Caenorhabditis elegans is a useful model to gain insight into the gene regulatory networks that assemble cellular networks. Mutations in a variety of genes can affect the sinusoidal locomotive pattern of C. elegans. We isolated the mutant jd1500 from a standard genetic screen looking for mutants in C. elegans that exhibit asymmetric locomotive patterns. The two aims of this study were to: 1) identify the gene and characterize its role in the gene regulatory network and 2) characterize the cells affected by the mutation. We reasoned that jd1500 likely disrupts the proper balance between dorsal and ventral body wall muscle contractions. By using three-point genetic mapping, we predicted the locus of jd1500 between -9.42 and -11.73 centimorgans of the X chromosome. Our results implicate the embryonic, cholinergic DB motor neurons as likely cellular targets of the mutation.
Effect of Ketamine on Social Avoidance in Socially Defeated Male and Female Syrian Hamsters
Creators: name: Guzman Bambaren, Alejandro
Publisher: name: Georgia State University
Year: 2016

description: Social stress can cause or exacerbate neuropsychiatric illnesses such as depression. Unfortunately, currently available treatments for these disorders are slow to take effect and are often ineffective. One promising novel treatment option is the anesthetic ketamine, which may have rapid-acting antidepressant effects in humans and rodents. These rodent studies, however, have primarily used artificial stressors to produce depression-like responses. Our lab uses an ethologically relevant rodent model of social stress in Syrian hamsters. We tested whether a single, intraperitoneal dose of ketamine reduces social avoidance, a common symptom of mental disorders, in male and female Syrian hamsters that have experienced social stress. Social avoidance was tested one day after ketamine injection. Eight days later, subjects were defeated again, and tested for avoidance the following day. Ketamine reduced avoidance one day but not nine days post-injection. These data suggest that ketamine can act rapidly to prevent depressive-like responses to social stress.
Induction Of Arginase-1 In MDSC Requires Exposure to CD3/CD28 Activated T Cells
Creators: name: Abdelbaky Abdelaal, Ahmed
Publisher: name: Georgia State University
Year: 2017

description: Tumor-induced myeloid derived suppressive cells (MDSC) have been reported to inhibit T cell responses. In our study MDSC isolated from tumor bearing mice showed potent inhibition of T-cell proliferation. However, surprisingly we observed that freshly isolated MDSC from the bone marrow of tumor bearing mice do not constitutively express arginase-1 until after exposure to T-cell proliferation. The aim of this study is to determine the mechanism by which arginase-1 is induced in MDSC following exposure to a proliferative T cell environment. We showed that treatment of MDSC with culture supernatant isolated from T cells activated with CD3/CD28 antibodies successfully induced arginase-1 expression and this process is independent of IL-10 and IFN?. This suggested that arginase-1 induction in MDSC can occur independently of cell-cell contact. Interestingly IL-2, ConA or PMA activated T-cell supernatant as well as supernatant from multiple cancer cell lines failed to induce arginase-1 in MDSC. We also showed that M-MDSC expressed higher levels of arginase-1 than G-MDSC after co-culture with CD3/CD28 activated T cells as well as its supernatant. In addition, other bone marrow cells have shown the potential to express arginase-1 following exposure to the same conditions. For example, we observed that healthy Ly6C+ monocytes but not mature granulocytes successfully expressed arginase-1.These data demonstrated that T cells activated through stimulation of TCR but not other means of activation induced arginase-1 enzyme expression.
Novel Effects of Mibefradil, An Anti-Cancer Drug, on White Adipocytes
Creators: name: Thompson, Sonia
Publisher: name: Georgia State University
Year: 2017

description: The present study was undertaken to investigate the effects of the T-type calcium channel blocker, Mibefradil, on white adipocytes. Unexpected for a T-type channel blocker, Mibefradil was found to increase intracellular calcium levels, cause lipid droplet fusion, and result in cell death. Calcium imaging of white adipocytes showed an increase of calcium concentration by Mibefradil at concentrations ranging from10-50 æM. The elevation in calcium by Mibefradil was significantly reduced by pretreatment of cells with Thapsigargin, an endoplasmic reticulum (ER) specific Ca ATPase inhibitor. Additionally, lipid droplet fusion and cell death were also attenuated by Thapsigargin pretreatment in white adipocytes. We conclude that Mibefradil elevated intracellular calcium levels, induced lipid droplet fusion and cell death in white adipocytes via mobilizing intracellular calcium stores from the ER. These results describe novel effects of Mibefradil on white adipocytes and may provide new insight into how this drug might be repurposed in obesity research.
Flagellin-Mediated Irradiation Protection in Mice
Creators: name: Oyewole-Said, Damilola
Publisher: name: Georgia State University
Year: 2017

description: Bone marrow (BM) transfer from flagellin-treated mice has been reported to improve the survival of lethally-irradiated mice. Although the mechanism for flagellin?s antiviral and antibacterial effects have been elucidated, there remains a gap in knowledge regarding its radioprotective effects.
Here, we report that flagellin treatment results in a 5-fold increase in the proliferation of Lin-Sca-1+C-Kit+(LSK) cells, a heterogeneous stem and multipotent cell population in BM, with the most striking increase within the ST-HSC, MPP2 and MPP3 subpopulations. Furthermore, the presence of TLR5 but not NLRC4 on radiosensitive, non-LSK cells in BM was both sufficient and necessary for the observed phenomenon. Finally, adoptive transfer of MPP3 cells along with an insufficient amount of whole bone marrow cells (WBM) to lethally-irradiated mice significantly improved their survival, recapitulating the effects of Whole bone marrow from flagellin-treated mice.
title: Queerying Japan: Transnational Perspectives on Politics, Society and Culture: Bericht zum internationalen Symposium am 06. und 07. Juli 2018 in Düsseldorf
Creators: name: Kobayashi, Ami
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 72
OpenAPI Interface Definition for the Communication of Study Regulations between SemaLogic and Answer Set Programming (ASP)
Creators: name: Goebel, Matthias
name: von der Heyde, Markus
Publisher: name: Zenodo
Year: 2024
Subjects: OpenAPI
SemaLogic
ASP
JSON
Semantics

description: The traditional way of feeding Answer Set Programming (ASP) is to define data in structured tables and feed these into the ASP solver to generate solutions. Formalizing the problem space is therefore left to the ASP programmers. The new approach to defining the logical structure in the formal specification language SemaLogic allows shifting part of the problem space definition towards the experts involved. In the case of study regulations, we proposed a first draft of the interface for the SemaLogic ASP communication protocol.

The resulting JSON interface is divided into three generic sections of information:
1.    Attributes: as symbols and their properties as attributed values
2.    Groups: to flexibly name the segmentation of all symbols
3.    Terms: to cover the logical relation between symbols as constraints

The OpenAPI interface definition is generic in the sense, that no assumptions about the structure of the coded knowledge are reflected in the data format.
description: Funding: German Federal Ministry of Education and Research, 16DHBKI024
What a home does
Creators: name: Jenkins, David
name: Brownlee, Kimberly
Publisher: name: The University of British Columbia
Year: 2023

description: Analytic philosophy has largely neglected the topic of homelessness. The few notable exceptions, including work by Jeremy Waldron and Christopher Essert, focus on our interests in shelter, housing, and property rights, but ignore the key social functions that a home performs as a place in which we are welcomed, accepted, and respected. This paper identifies a ladder of home-related concepts which begins with the minimal notion of temporary shelter, then moves to persistent shelter and housing, and finally to the rich notion of a home which focuses on meeting our social needs including, specifically, our needs to belong and to have meaningful control over our social environment. This concept-ladder enables us to distinguish the shelterless from the sheltered; the unhoused from the housed; and the unhomed from the homed. It also enables us to decouple the concept of a home from property rights, which reveals potential complications in people’s living arrangements. For instance, a person could be sheltered but unhoused, housed but homeless, or, indeed, unhoused but homed. We show that we should reserve the concept of home to capture the rich idea of a place of belonging in which our core social needs are met.
Transcriptional Regulation of the Caenorhabditis elegans GABAergic Terminal Selector, unc-30
Creators: name: Nunneley, Michael
Publisher: name: Georgia State University
Year: 2017

description: Understanding gene regulatory networks (GRN) that lead to the differentiation of individual neuron classes and the assembly of these neurons into functional cellular networks is critical to the development of the nervous system. In the nematode Caenorhabditis elegans, the 19 GABAergic motor neurons (MNs) are divided into two sub-classes that arise at different developmental stages with different lineages: the embryonic DD and post-embryonic VD MNs. The terminal selector gene unc-30, activates a battery of genes leading to the terminal differentiation of both sub-classes to give the DD and VD MNs the GABAergic fate. A candidate gene approach was used to identify transcriptional regulators of unc-30 and determine whether the DD and VD MNs share the same GRN. The identification of genes regulating unc- 30 in one sub-class but not the other is further evidence of differential GRNs between the DD and VD MNs, and suggests that unc-30 acts as a convergence point between the sub-classes.
title: Arbeitstagung der Konferenz der Einrichtungen für Frauen- und Geschlechterstudien im deutschsprachigen Raum (KEG) 2018: Bericht zur 16. Arbeitstagung am 26. bis 27. September 2018 in Wien
Creators: name: Wrede, Birgitta
name: Pache, Ilona
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 76
Effects of D-Delta Tocotrienol on High-Fat Diet-Induced Peripheral Inflammation
Creators: name: Sharma, Shaligram
Publisher: name: Georgia State University
Year: 2017

description: Little is known about the ability of d-ë-tocotrienol to protect against obesity-induced inflammation. These studies were conducted to determine whether d-ë-tocotrienol inhibits highfat diet (HFD)-induced peripheral inflammation, and to explore potential mechanisms by which d-ë-tocotrienol affects inflammation. In two animal experiments, mice were fed a low-fat control diet, a high-fat control diet, or a HFD supplemented with d-ë-tocotrienol: 400 mg/kg diet (experiment #1) or 60 mg/kg body weight (experiment #2) for 14 weeks. Expression of inflammatory and anti-inflammatory markers was measured in liver and white adipose tissue, and phosphorylation of STAT3 was measured using western blot. d-ë-tocotrienol mitigate HFDinduced hepatic inflammation, despite having no effect on body weight, suggesting direct antiinflammatory effects of d-ë-tocotrienol independent of body weight loss. Mechanistic studies in 3T3-L1 adipocytes indicated that d-ë-tocotrienol suppresses LPS-induced inflammation through down-regulating STAT3 signaling. The potential for d-ë-tocotrienol as a treatment of obesity and related metabolic diseases requires further investigation.
Quantum Simulation of Grand Unified Theory Baryogenesis, A Proof-of-Concept Study Bridging Cosmology and Quantum Computing
Creators: name: Kumar, Mukul
Publisher: name: Zenodo
Year: 2025

description: We present the first quantum simulation of a baryogenesis model using real quantum hardware. Baryogenesisexplains the observed matter-antimatter asymmetry of our universe, a phenomenon that requires CP-violation amongSakharov’s conditions. We develop a novel quantum algorithm that directly encodes particle decay processes withCP-violation, implementing it on IBM’s superconducting quantum processors. Our approach provides a particle-levelperspective that complements classical Boltzmann equation methods, offering new insights into how microscopicCP-violating interactions propagate to macroscopic asymmetries. We demonstrate a proof-of-principle simulation ofa simplified SU(5) GUT-inspired model, comparing classical numerical solutions with both quantum simulator andhardware results. Despite current hardware limitations, our algorithm shows promising agreement with theoreticalpredictions and establishes a foundation for more complex quantum simulations of early universe processes as quantumhardware advances
Rhamnus prinoides (gesho) extract Inhibits Streptococcus mutans and Candida albicans Polymicrobial Biofilm Formation
Creators: name: Fathi, Raghda
Publisher: name: Georgia State University
Year: 2018

description: Polymicrobial biofilms contain multiple microbial species encased in an extracellular polymeric matrix. Synergistic interactions within polymicrobial biofilms contribute to elevated antibiotic resistance and chronic infections; furthermore, prevention and treatment is still an unresolved issue. The yeast Candida albicans and the Gram positive bacterium Streptococcus mutans are biofilm-forming oral pathogens that interact mutualistically, and were investigated in this work. Crystal violet-based biofilm formation assays were used to measure the effect of extracts from Rhamnus prinoides (gesho), an East African plant used in traditional medicine, on biofilm formation. The biomass of dual species biofilms was 70% greater than single-species biofilms, indicating a synergistic interaction. Treatment with gesho extracts reduced both single-species and polymicrobial biofilm biomass by more than 90% relative to controls. Imaging by epifluorescence microscopy supported the findings of the biofilm formation assays. In conclusion, gesho exhibited significant potential for use as an anti-biofilm agent and warrants further investigation.
Reappraisal of the sauropod dinosaur taxa from the Upper Cretaceous Winton Formation of Queensland, Australia, through 3D digitisation and description of new specimens
Creators: name: Rigby, Samantha L.
Publisher: name: Swinburne
Year: 2024

description: Sauropods were massive herbivorous quadrupedal dinosaurs with small heads, long necks, and long tails. I described and digitally scanned thirteen sauropod specimens from the Winton Formation. Of these, ten specimens were assigned to "Diamantinasaurus matildae" (including a juvenile specimen), and one to "Savannasaurus elliottorum". One of the remaining two specimens, possibly represents a distinct taxon, and is currently kept in open nomenclature as Somphospondyli indet.; the other cannot be classified beyond Sauropoda indet. Thus, the Winton Formation sauropod fauna has been reduced from four species to two, with 21 specimens assigned to "D. matildae" and two to "S. elliottorum".
title: #Betweenspaces – Nutzen digitaler Medien für die Geschlechter-forschung: Bericht zum Mittelbau-Workshop des Netzwerks am 22. Juni 2018
Creators: name: Mense, Lisa
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 80
Longalatedes elymi
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Longalatedes
Longalatedes elymi

description: Longalatedes elymi (Treitschke, 1825)
 Bionomics. FP: VI–VII. Steppe river valleys and lake shores.
 Known localities. P: Pavlodarskoye, Sychevka, Baydala; S: Sofiyevka; AK: Borly; B: Kurkeli, Airtas; M: Koktobe, Koktas, Zmeinyi Yar; A: Kurkol.
 Literature: Shek (1975, as Arenostola); Titov et al. (2017b).
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
title: Komponistinnen und Interpretinnen – sie gewinnen mehr und mehr an Bedeutung: Bericht zur Schubertiade in Schwarzenberg 2018
Creators: name: Büchter-Römer, Ute
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 81
Elucidating Mechanisms of Gefitinib Resistance that Instigate Cancer Progression
Creators: name: Faisthalab, Raeesa
Publisher: name: Georgia State University
Year: 2018

description: In recent years, cancer treatments have progressed substantially. However, the tumor microenvironment is dynamic and continuously evolving thereby resulting in decreased efficacy to therapies, and resistant cancer cells. The development of drug resistance in cancer patients may potentially trigger or instigate disease progression in the presence of therapeutic interventions. In this study, we investigated effects of chronic Gefitinib treatments in a lung cancer cell line model. Gefitinib is a tyrosine kinase inhibitor targeting specific mutations within the epidermal growth factor receptor (EGFR). Lung cancer cells treated for extended periods of time with Gefitinib displayed resistant phenotypes, typically characterized by DNA damage, epithelial- mesenchymal transition (EMT) as well as heightened and sustained levels of reactive oxygen species (ROS). Furthermore, we uncovered novel cancer resistant phenotypes, namely dysregulated mitochondrial biogenesis, endoplasmic reticulum (ER) alterations, cellular calcium levels and propensity towards bypassing senescence.
ALZHEIMER'S DISEASE: A COMPREHENSIVE REVIEW OF PATHOLOGY, EPIDEMIOLOGY, AND THERAPEUTIC ADVANCES
Creators: name: Pavankumar P. Wankhade * Anand A Jadhav, Vedantika R. Salunkhe, Harsh P. Mane, Rushikesh B. Patil
Publisher: name: Zenodo
Year: 2024

description: Alzheimer’s disease (AD), the most common form of dementia, is characterized by neuritic plaques and neurofibrillary tangles resulting from the accumulation of amyloid-beta peptide in the brain. Since its first description by Alois Alzheimer in 1907, the disease has been associated with significant cognitive decline and loss of neurons. AD and other cerebral disorders can stem from various causes, including genetic factors, infections, cardiovascular issues, and more. With approximately 50 million AD patients worldwide, a number expected to triple by 2050, the disease imposes a substantial economic burden, with annual global costs estimated at $1 trillion. This review provides an overview of AD pathology, diagnosis, causes, and current treatments. It explores the historical background, epidemiology, neuropathology, and pathophysiology of AD. The review also highlights emerging therapies targeting multiple pathogenic mechanisms, such as tau and Aβ aggregation, inflammation, and oxidative damage. By synthesizing current research and trends, this article aims to offer valuable insights for researchers, practitioners, and policymakers involved in addressing the challenges of Alzheimer’s disease.

Keywords: Beta-amyloid plaques, Neurofibrillary tangles, Synaptic loss, Exercise intervention, Diagnosis and treatment
Hypoxia Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinoma
Creators: name: Choi, Da Hoon
Publisher: name: Georgia State University
Year: 2018

description: Human papillomavirus (HPV)-negative (-ve) oropharyngeal squamous cell carcinomas (OPSCCs) are associated with poorer overall survival (OS) compared to HPV-positive (+ve) OPSCCs. The major obstacle to improving outcomes of HPV -ve patients is the absence of good biomarkers. Herein, we investigated the role of centrosome amplification (CA) as a prognostic marker in HPV ?ve OPSCCs. We first quantitatively assessed CA in OPSCC tumor samples and found that HPV -ve OPSCCs exhibit higher CA compared to HPV +ve OPSCCs, and was associated with poor OS even after adjusting for potentially confounding variables. Further, the expression of genes associated with hypoxia and CA was significantly higher in HPV -ve OPSCCs than in HPV +ve OPSCCs. We further uncovered a mechanism by which hypoxia-induced HIF-1à downregulates miR-34a resulting in cyclin D1 overexpression and rampant CA in HPV -ve OPSCCs. Our findings demonstrate that assessment of CA may aid in therapeutic decision-making for these patients.
Lenisa geminipuncta
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Lenisa
Lenisa geminipuncta

description: Lenisa geminipuncta (Haworth, 1809) * (Fig. 15)
 Bionomics. FP: VIII. Hygrophilous species. River valleys.
 Known locality. P: Zhertumsyk.
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
title: 10th European Feminist Research Conference. Difference, Diversity, Diffraction: Confronting Hegemonies and Dispossessions: Bericht zur Konferenz vom 12. bis zum 15. September 2018 an der Universität Göttingen
Creators: name: Beaufaÿs, Sandra
name: Herrmann, Jeremia
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 83
Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells
Creators: name: Sreenivasan, Lakshana
name: Li, Ling Vicky
name: Leclair, Pascal
name: Lim, Chinten James
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Of the four molecular subgroups, Group 3 MB is the most aggressive and has the worst prognosis. To understand the origins of chemoresistance involving IL-6/STAT3 signaling, we used in vitro co-culture systems to investigate the contribution of microglia as a brain tumor microenvironment cellular source of paracrine cytokines that promotes acquired drug resistance in Group 3 MB. MB cells subjected to co-culture with microglia exhibited increased expression of phosphorylated JAK1 and STAT3, which was correlated with enhanced resistance to vincristine. We found that both microglia and MB cells co-cultured with microglia secreted significant quantities of IL-6, indicating that IL-6 is a paracrine and autocrine cytokine able to initiate and sustain STAT3 activity in MB cells. Surprisingly, IL-6R−/− MB cells, which cannot respond to exogenous IL-6 stimuli, were responsive to microglia co-culture induced activation of STAT3 and chemoresistance. Subsequently, we found that MB cells conditioned in vitro with the IL-6 family cytokines, IL-6, OSM, LIF, or IL-11, exhibited enhanced JAK1/STAT3 activity and chemoresistance. Intriguingly, MB cells conditioned with any one of the IL-6 family cytokine secreted multiple IL-6 family cytokines, implicating a feedback network involving multiple cytokines. The IL-6 family cytokine receptors share a common signal transducing β-subunit, gp130, which may be targeted to mitigate tumor chemoresistance. We showed that microglia co-culture failed to induce chemoresistance of gp130−/− MB cells, and that combination treatment using gp130 inhibitors, or with the JAK inhibitor ruxolitinib, effectively overcame the observed resistance to vincristine in gp130 expressing MB cells. Our in vitro studies highlight the gp130/JAK/STAT pathway as a therapeutic target in combating acquired treatment resistance in Group 3 MB.
Archanara dissoluta
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Archanara
Archanara dissoluta

description: Archanara dissoluta (Treitschke, 1825)
 Bionomics. FP: VIII–IX. Hygrophilous species. River valleys and lake shores.
 Known localities. Z: Urlyutyub, Shipichka; T: Terenkol, Baykonis, Ay-Sary, Alash; P: Pavlodarskoye, Zhertumsyk, Baydala, Ken-Aral; B: Airtas; M: Koktobe, Koktas, Zmeinyi Yar; E: Zhartas, Karazhar, Ulken Ak-Zhar.
 Literature: Titov et al. (2017b).
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
Factors Influencing Consumers Repurchase Intention Green Cosmetics in Vietnam: A Qualitative Study
Creators: name: Tran Thi Song Lam
Publisher: name: Zenodo
Year: 2024

description: The objective of this article is to evaluate factors impacting on consumers’ repurchase intention green cosmetics of Vietnamese consumers based on qualitative research. The article conducted in-depth interviews with consumers who have purchased green cosmetics in the last 12 months. A total of 40 individuals are regular customers of green cosmetics and spa stores in Vietnam. In addition, the study conducted interviews with 5 experts in the Vietnam Natural Products Science Association. The data was compiled using Nvivo software and has summarized the factors affecting consumers’ repurchase intention green cosmetics in Vietnam.
title: Plädoyer für einen ‚reflektierten Universalismus‘: Bericht zum Vortrag „Feminismen und Geschlechterkonflikte in postkolonialen Welten“ von Ilse Lenz am 20. Juni 2018 in Bochum
Creators: name: Mauer, Heike
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 88
title: RINGS conference „The State of the Art of Feminist and Gender Studies: Convergences, Divergences and Plurality of Views”
Creators: name: Thym, Anika
name: Alemann, Annette
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 90
title: Preisverleihung der Stiftung „Aufmüpfige Frauen“: Bericht zur Veranstaltung am 12. Oktober 2018 in Dortmund
Creators: name: Metz-Göckel, Sigrid
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2018
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2018, no. 43, p. 94
Denticucullus pygmina
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Denticucullus
Denticucullus pygmina

description: Denticucullus pygmina (Haworth, 1809)
 Bionomics. FP: IX. Hygrophilous species. River valleys and lake shores.
 Known localities. P: Pavlodarskoye; B: Zhumbak; E: Ulken-Koyandy; M: Koktas.
 Literature: Titov et al. (2017b).
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
Using Biomarkers to Optimize the Rehabilitation of Wild Raptors
Creators: name: Haman, Molly
Publisher: name: Georgia State University
Year: 2018

description: The purpose of this study is to explore the use of stress physiology biomarkers in wildlife rehabilitation. We examined collection, extraction and enzyme immunoassay protocols in order to identify the optimal methods for testing corticosterone levels in injured raptors at a wildlife rehabilitation center. Corticosterone levels were measured periodically during the raptors' rehabilitation using noninvasive techniques. This study focuses on three species: Red-Tailed Hawks (Buteo jamaicensis), Red-Shouldered Hawks (Buteo lineatus), and Barred Owls (Strix varia). Fecal samples were collected from patients from all three species from May 2017 to March 2018. This information will contribute to our understanding of the stress profile of raptors in rehabilitation, and will allow for future studies to employ the methods validated by this project.
Characterizing a Novel Forward Locomotion Mutant in Caenorhabditis Elegans
Creators: name: Randall, Christian
Publisher: name: Georgia State University
Year: 2018

description: C. elegans provides a number of tools for understanding cellular networks and neural connections. We identified jd1500 in previous reports as a mutation that affects forward locomotion, which is unusual. Our aims were to: 1) identify the gene responsible for the phenotype that jd1500 exhibits and 2) distinguish the basis for the locomotive asymmetries. Using next-gen whole genome sequencing, we were able to identify specific genes that are likely responsible for the phenotype it shows. Our results suggest that gap junction mutations mask jd1500 activity, but also suggest that jd1500 masks acr-2 activity.
Effect of Monoethanolamine on the Lipid Metabolism of Prostate Cancer Cells
Creators: name: McFaline-Figueroa, Jennifer
Publisher: name: Georgia State University
Year: 2018

description: The ability of cancer cells to synthesize and store lipids in the form of lipid droplets (LDs) gives them a proliferative advantage over normal cells. Here, we elucidate the effect of monoethanolamine (Etn) on the lipid metabolism of LD-rich prostate carcinoma (PC3) cells. Etn is a ubiquitous molecule that serves as a phospholipid precursor and has been shown to have anticancer activity, although its mechanism of action is not fully understood. PC3 cells were treated with Etn and evaluated with a combination of biochemical and cell biology techniques. Treatment with Etn caused a decrease in cytosolic LD abundance induced by Ca2+-stimulated lipolysis. Our study effectively implicates the disruption of lipid metabolism as a contributor to Etn-induced cell death. This finding opens new avenues for the development of LD-targeted anticancer therapy.
Hypocoena stigmatica
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Hypocoena
Hypocoena stigmatica

description: Hypocoena stigmatica (Eversmann, 1855)
 Bionomics. FP: VI. Hygrophilous species. River valleys and lake shores.
 Known localities. T: Terenkol; A: Belaya.
 Literature: Titov et al. (2017b).
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
Photedes fluxa
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Photedes
Photedes fluxa

description: Photedes fluxa (Hübner, 1809)
 Bionomics. FP: VII–VIII. Mesophilous species. Open woodlands, meadows, steppes.
 Known localities. P: Pavlodarskoye; A: Kurkol; B: Kurkeli, Shonai.
 Literature: Titov et al. (2017b).
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 337, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
Ogilia leuconephra
Creators: name: Titov, Sergey V.
name: Volynkin, Anton V.
name: Morozov, Pavel S.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ogilia
Ogilia leuconephra

description: Ogilia leuconephra (Hampson, 1908)
 Bionomics. FP: VIII. Meso-hygrophilous species. Forests and woodlands, meadows.
 Known locality. S: Sharbakty.
 Literature: Titov et al. (2017b).
description: Published as part of Titov, Sergey V., Volynkin, Anton V. & Morozov, Pavel S., 2024, Revised checklist of the superfamily Noctuoidea (Lepidoptera) of Northeast Kazakhstan (Pavlodar Region), pp. 288-376 in Ecologica Montenegrina 73 on page 338, DOI: 10.37828/em.2024.73.22, http://zenodo.org/record/13248329
Calcium Release from the Endoplasmic Reticulum Is Required for the Anticancer Action of Mibefradil
Creators: name: Ghareeb, Ahmed
Publisher: name: Georgia State University
Year: 2018

description: Cancer is the modern, most persistent serial killer. Cancer cells intelligently recruit and utilize all the biological functions to support their survival, proliferation, and invasion, which require altering and reprogramming a lot of the normal signals and pathways. Calcium (Ca2+) is a fundamental secondary messenger involved in most of the regular cellular functions, not only the survival processes but also, the apoptotic death. Cancer cells exhibit unique expression levels of T-type Ca2+ channels (TTCC) that vary according to the tumor type, stage, and the channel isoform. The aberrant expression of the TTCC family (Cav3.1, Cav3.2, and Cav3.3) genes in cancer cells significantly contribute in the remodeled Ca2+ signaling that mediates many cancer cell functions including mitochondrial energy production, proliferation, angiogenesis, metastasis, and sensitivity to cell death. Accordingly, the TTCC blockers were proposed for their anti-cancer effect. Mibefradil (MBF) (Posicor?) is a TTCC blocker initially introduced into the pharmaceutical market in 1997 as an FDA-approved antihypertensive drug but voluntarily withdrawn due to drug-drug interactions. 10 years later, MBF was qualified for drug orphan designation by the FDA for the treatment of pancreatic, ovary, and brain cancers. Herein, we investigate the anti-cancer effect of MBF on different cell lines by determining its IC50 and indicate MBF-induced endoplasmic reticulum Ca2+ release as a key for the anticancer effect of MBF. Moreover, we identify the effect of MBF on important cytoplasmic organelles such as mitochondria and lipid droplets (LDs). Further, we demonstrate that MBF reduces the number of the lipid droplets and affects the cellular lipid storage by inducing lipolysis in cancer cells.