cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Disruption of human plasma cell differentiation by an environmental polycyclic aromatic hydrocarbon: a mechanistic immunotoxicological study
Creators: name: Allan, Lenka L
name: Sherr, David H
Publisher: name: BioMed Central
Year: 2015

description: Background: The AhR is a ligand-activated transcription factor that mediates immunosuppression induced by environmental PAH and HAH. Recently, a critical role for the AhR in development of T cells involved in autoimmunity (Th17 and Treg) has been demonstrated, supporting the hypothesis that the AhR plays a key role in immune regulation both in the presence and absence of environmental ligands. Despite these results with T cells systems, little is known of the role that the AhR plays in B cell development. We have demonstrated that B cell activation with CD40 ligand, a stimulus that models adaptive immunity, induces AhR expression in primary human B cells, suggesting that activation may increase human B cell sensitivity to AhR ligands and that the AhR may play a role in B cell development. Methods To test these possibilities, we developed an in vitro system in which activated human B cells expressing high AhR levels are induced to differentiate into plasma cells. Consequently, the effects of benzo [a]pyrene, a prototypic environmental AhR ligand, on plasma cell differentiation could be investigated and this chemical could be exploited essentially as drug probe to implicate the role of the AhR in plasma cell development. Results A previously unattainable level of B cell differentiation into plasma cells (up to 45% conversion) was observed. Benzo [a]pyrene significantly suppressed that differentiation. γ-Irradiation after an initial proliferation phase induced by CD40 ligand and immediately prior to initiation of the differentiation phase blocked cell growth but did not affect cell viability or plasma cell differentiation. B [a]P suppressed differentiation whether or not cell growth was inhibited by γ-irradiation. Conclusions 1) Extensive proliferation is not required during the differentiation phase per se for CD40L-activated human B cells to undergo plasma cell differentiation, and 2) an environmental PAH blocks both proliferation and differentiation of AhR expressing B cells. The results uncover a new mechanism by which environmentally ubiquitous PAHs may negatively impact human B cell-mediated immunity.
РАЗРАБОТКА КОНСТРУКЦИИ ПАССИВНОГО ДАТЧИКА ДАВЛЕНИЯ ДЛЯ БЕСПРОВОДНОЙ СИСТЕМЫ ДИСТАНЦИОННОГО КОНТРОЛЯ В ШИНАХ АВТОМОБИЛЯ
Creators: name: Сметанин Егор Александрович
Publisher: name: Colloquium-journal
Year: 2020
Subjects: датчик давления
емкостное преобразование
консольный чувствительный элемент.

description: Статья посвящена вопросам конструирования емкостного датчика давления. Дистанционный контроль является актуальной задачей. Разработана математическая модель основных элементов датчика давления. Получена зависимость емкости от перемещения электромеханического консольного чувствительного элемента. Рассмотрены конструкции электромеханического консольного чувствительного элемента.
АНАЛИЗ МЕТОДОВ АВТОМАТИЧЕСКОЙ ИДЕНТИФИКАЦИИ ОБОРУДОВАНИЯ В СИСТЕМАХ АВТОМАТИЧЕСКОГО УПРАВЛЕНИЯ
Creators: name: Словеснов Никита Александрович
name: Мирсаитов Сергей Фаритович
name: Светличный Владимир Викторович
name: Словеснов Егор Александрович
Publisher: name: Colloquium-journal
Year: 2020
Subjects: автоматическая система управления технологическим процессом
идентификация оборудования
RFID
NFC
штрих-код
ручной ввод.

description: Для обеспечения подготовки мобильных реакторов приготовления растворов к следующей серии препарата на фармацевтическом предприятии используются автоматизированные системы очистки и стерилизации. К данной системе подключается тот или иной мобильный реактор со своими индивидуальными входными параметрами: объем, количество пневматических клапанов, наличие/отсутствие технологических элементов (барботажная труба, пробоотборник и т.д.), количество датчиков температуры, электропроводности и давления. В связи с этим в системе управления необходимо предусмотреть возможность выбора этих параметров, а лучше возможность их автоматического определения при подключении того или иного реактора, что обеспечит возможность автоматического ввода индивидуальной конфигурации настроек параметров работы автоматизированной системы очистки и стерилизации, с целью оптимальной работы данного оборудования по критериям: надежности, точности, валидируемости процесса.
WAYS TO APPLY TECHNICAL METHODS OF PEDAGOGY OF SPECIAL PHYSICAL TRAINING IN THE EFFECTIVE TRAINING OF SPECIAL FORCES SOLDIERS
Creators: name: Iskhakov, Akmaljon
name: Melikuziev, Murodbek
name: Abdirizikov, Otabek
name: Melikuziev, Rustambek
Publisher: name: Zenodo
Year: 2024

description: In this paper we describe the aspects of mining collective action the arrest of criminals on the lessons of physical training. Offer some methodological techniques when working in «pairs of combat and combat threes», that allows to solve operatively-service problems quickly and with maximum efficiency without additional application of physical force and special means.
Unique Selectivity Reversal in the Complexation of Uranium(VI) and Plutonium(IV) with Two Novel C-Pivoted Tripodal Amide Ligands: Extraction and Liquid Membrane Transport Studies
Creators: name: Karak, Ananda
name: Mahanty, Bholanath
name: Mohapatra, Prasanta K.
name: Egberink, Richard J. M.
name: Valsala, Thisur P.
name: Sathe, Darshan B.
name: Bhatt, Raj B.
name: Huskens, Jurriaan
name: Verboom, Willem
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Two new carbon pivoted tripodal amide-containing ligands with different spacers (LI: -CH2- spacer; LII: -CH2-CH2- spacer) have been investigated for the liquid–liquid extraction of tetravalent plutonium and hexavalent uranium from nitric acid feed solutions. The studies were carried out using the ligand solutions prepared in 95% n-dodecane + 5% isodecanol. Pu(IV) extraction was higher than that of U(VI) at 3 M HNO3 for ligand LI which was just the opposite for ligand LII. Increase of the nitric acid concentration resulted in increasing extraction of both metal ions. Isodecanol variation studies exhibited decrease in the extraction of Pu(IV) and U(VI) with increasing isodecanol content in the organic phase. Greater that 98% stripping of Pu(IV) and U(VI) was obtained from the complexes of LI and LII using 0.5 M HNO3 + 0.1 M HEDTA and 1 M Na2CO3, respectively. The slope analysis study suggested the formation of 1:2 (ML2) species with Pu(IV) as well as U(VI) with both ligands at 3 M HNO3. Temperature variation studies showed that the extraction of U(VI) and Pu(IV) with both ligands is exothermic in nature. Supported liquid membrane transport experiments using 0.11 M ligands (LI and LII) in 95% n-dodecane + 5% isodecanol indicated poor transport (<10% after 2 h) of U(VI) and Pu(IV).
A randomized controlled trial of Human Papillomavirus (HPV) testing for cervical cancer screening: trial design and preliminary results (HPV FOCAL Trial)
Creators: name: Ogilvie, Gina
name: Van Niekerk, Dirk J.
name: Krajden, Mel
name: Martin, Ruth E.
name: Ehlen, Thomas G.
name: Ceballos, Kathy
name: Peacock, Stuart J.
name: Smith, Laurie W.
name: Kan, Lisa
name: Cook, Darrel A.
name: Mei, Wendy
name: Stuart, Gavin C.
name: Franco, Eduardo L.
name: Coldman, Andrew J.
Publisher: name: BioMed Central
Year: 2016

description: Background: In the HPV FOCAL trial, we will establish the efficacy of hr-HPV DNA testing as a stand-alone screening test followed by liquid based cytology (LBC) triage of hr-HPV-positive women compared to LBC followed by hr-HPV triage with ≥ CIN3 as the outcome. Methods/Design: HPV-FOCAL is a randomized, controlled, three-armed study over a four year period conducted in British Columbia. It will recruit 33,000 women aged 25-65 through the province's population based cervical cancer screening program. Control arm: LBC at entry and two years, and combined LBC and hr-HPV at four years among those with initial negative results and hr-HPV triage of ASCUS cases; Two Year Safety Check arm: hr-HPV at entry and LBC at two years in those with initial negative results with LBC triage of hr-HPV positives; Four Year Intervention Arm: hr-HPV at entry and combined hr-HPV and LBC at four years among those with initial negative results with LBC triage of hr-HPV positive cases Discussion: To date, 6150 participants have a completed sample and epidemiologic questionnaire. Of the 2019 women enrolled in the control arm, 1908 (94.5%) were cytology negative. Women aged 25-29 had the highest rates of HSIL (1.4%). In the safety arm 92.2% of women were hr-HPV negative, with the highest rate of hr-HPV positivity found in 25-29 year old women (23.5%). Similar results were obtained in the intervention arm HPV FOCAL is the first randomized trial in North America to examine hr-HPV testing as the primary screen for cervical cancer within a population-based cervical cancer screening program. Trial Registration: International Standard Randomised Controlled Trial Number Register, ISRCTN79347302
Application of Daily Air Pollutant Index Forecasting Model Based on Semi-Empirical Statistical Theory: Case Study in Hanoi, Vietnam
Creators: name: Pham Thi Thu Ha
name: Pham Thi Viet Anh
name: Dung, Do Manh
name: Bach, Duong Ngoc
name: Trang, Phan Thu
name: Nguyen The Hung
name: And Pham Ngoc Ho
Publisher: name: Thai Society of Higher Education Institutes on Environment
Year: 2020
Subjects: Modeling
Daily air pollution index
Model's efficiency

description: EnvironmentAsia, 13, 2, 15-30
title: Tableau d'assemblage Afrique Centrale 1:200000 1962
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Tableau d'assemblage Afrique ceentrale au 1:200000, 274 feuilles
Source Apportionment Analysis of Volatile Organic Compounds Using Positive Matrix Factorization Coupled with Conditional Bivariate Probability Function in the Industrial Areas
Creators: name: Kanisorn Jindamanee
name: Sarawut Thepanondh
name: Natchanon Aggapongpisit
name: Sirapong Sooktawee
Publisher: name: Thai Society of Higher Education Institutes on Environment
Year: 2020
Subjects: Benzene
Conditional bivariate probability function (CBPF)
Positive matrix factorization (PMF)
Source apportionment

description: EnvironmentAsia, 13, 2, 31-49
Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo
Creators: name: Geetha-Loganathan, Poongodi
name: Nimmagadda, Suresh
name: Christ, Bodo
name: Huang, Ruijin
name: Scaal, Martin
Publisher: name: BioMed Central
Year: 2016

description: Background: Pattern formation of the limb skeleton is regulated by a complex interplay of signaling centers located in the ectodermal sheath and mesenchymal core of the limb anlagen, which results, in the forelimb, in the coordinate array of humerus, radius, ulna, carpals, metacarpals and digits. Much less understood is why skeletal elements form only in the central mesenchyme of the limb, whereas muscle anlagen develop in the peripheral mesenchyme ensheathing the chondrogenic center. Classical studies have suggested a role of the limb ectoderm as a negative regulator of limb chondrogenesis. Results: In this paper, we investigated the molecular nature of the inhibitory influence of the ectoderm on limb chondrogenesis in the avian embryo in vivo. We show that ectoderm ablation in the early limb bud leads to increased and ectopic expression of early chondrogenic marker genes like Sox9 and Collagen II, indicating that the limb ectoderm inhibits limb chondrogenesis at an early stage of the chondrogenic cascade. To investigate the molecular nature of the inhibitory influence of the ectoderm, we ectopically expressed Wnt6, which is presently the only known Wnt expressed throughout the avian limb ectoderm, and found that Wnt6 overexpression leads to reduced expression of the early chondrogenic marker genes Sox9 and Collagen II. Conclusion: Our results suggest that the inhibitory influence of the ectoderm on limb chondrogenesis acts on an early stage of chondrogenesis upsteam of Sox9 and Collagen II. We identify Wnt6 as a candidate mediator of ectodermal chondrogenic inhibition in vivo. We propose a model of Wnt-mediated centripetal patterning of the limb by the surface ectoderm.
Ανάπτυξη διαλειτουργικής υπηρεσίας για δημόσιες προμήθειες βασιζομένη στις προδιαγραφές Peppol
Creators: name: Μπίνας, Νικόλαος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Peppol
subject: e-Procurement

description: Θέμα της διπλωματικής εργασίας είναι η ανάλυση, ανάπτυξη και αξιολόγηση της διαδικασίας ηλεκτρονικής υποβολής προσφοράς στην διαδικασία των δημοσίων προμηθειών βασιζόμενη στις προδιαγραφές που θέτει το PEPPOL. Το PEPPOL BIS είναι ένα σύνολο επιχειρησιακών, λειτουργικών, σημασιολογικών αλλά και τεχνικών προδιαγραφών για την υλοποίηση διασυνοριακών ηλεκτρονικών συναλλαγών στις δημόσιες προμήθειες. Σημαντικό κομμάτι των συναλλαγών αυτών αποτελεί και η ηλεκτρονική υποβολή προσφοράς σε διαγωνισμό προμήθειας που θα μελετηθεί στην παρούσα εργασία. Στόχος της παρούσας διπλωματικής εργασίας είναι η ανάπτυξη διαλειτουργικής υπηρεσίας που αφορά τις δημόσιες προμήθειες και βασίζεται στις προδιαγραφές PEPPOL. Μελετώντας τις προδιαγραφές που ορίζει το PEPPOL BIS Profile P003 υλοποιήθηκε διαδικτυακή εφαρμογή με σκοπό την υποστήριξη της ανταλλαγής ηλεκτρονικών μηνυμάτων μεταξύ οικονομικού φορέα και αναθέτουσας αρχής για την υποβολή προσφοράς η οποία ακολουθεί την πρόσκληση υποβολής προσφορών. Για την ανάπτυξη της συγκεκριμένης υπηρεσίας μελετήθηκαν σε βάθος οι προδιαγραφές που ορίζει το PEPPOL BIS αλλά και οι κανόνες συμμόρφωσης που απαιτούνται για την εύρυθμη αλλά και αποτελεσματική λειτουργία της εφαρμογής. Σαν αποτέλεσμα των παραπάνω σχεδιάστηκε διεπαφή η οποία θα έχει την δυνατότητα να δέχεται ηλεκτρονικά μηνύματα που αφορούν την πρόσκληση υποβολής προσφοράς και χρησιμοποιώντας τα να μπορεί να παράξει XML αρχείο που είναι απαραίτητο για την εκτέλεση της ηλεκτρονικής συναλλαγής που αφορά την υποβολή προσφορών σε διαγωνισμούς προμήθειας. Με την υλοποίηση του συγκεκριμένου λογισμικού επιτυγχάνεται η διαλειτουργικότητα, η αποφυγή λαθών κατά την σύνταξη της προσφοράς και συνεπώς η βελτιστοποίηση της ηλεκτρονικής συναλλαγής.
Requirements for Beneficial Electrochemical Restructuring: A Model Study on a Cobalt Oxide in Selected Electrolytes
Creators: name: Villalobos, Javier
name: González-Flores, Diego
name: Urcuyo, Roberto
name: Montero, Mavis L.
name: Schuck, Götz
name: Beyer, Paul
name: Risch, Marcel
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: catalyst activation
subject: Co-based electrocatalysts
subject: electrochemical reconstruction
subject: electrolyte
subject: oxygen evolution reaction
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: The requirements for beneficial materials restructuring into a higher performance oxygen evolution reaction (OER) electrocatalyst are still a largely open question. Here erythrite (Co3(AsO4)2·8H2O) is used as a Co-based OER electrocatalyst to evaluate its catalytic properties during in situ restructuring into an amorphous Co-based catalyst in four different electrolytes at pH 7. Using diffraction, microscopy, and spectroscopy, a strong effect in the restructuring behavior is observed depending of the anions in the electrolyte. Only carbonate electrolyte can activate the catalyst material, which is related to its slow restructuring process. While the catalyst turnover frequency (TOF) undesirably reduces by a factor of 28, the number of redox active sites continuously increases to a factor of 56, which results in an overall twofold increase in current of the restructured catalyst after 800 cycles. The activation is attributed to an adequate local order, a high Co oxidation state close to 3+, and a high number of redox-active Co ions. These three requirements for beneficial restructuring provide new insights into the rational design of high-performance OER catalysts by electrochemical restructuring.
title: Ανάλυση των στρατηγικών κυκλικής οικονομίας στη διαδικασία παραγωγής πλαστικών μιας χρήσης
title: Analyzing circular economy strategies in the production process of disposable plastic
titleType: AlternativeTitle
Creators: name: Λυμάκη, Μαρίνα
name: Lymaki, Marina
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Βιωσιμότητα
subject: Βιώσιμη παραγωγή
subject: Επιχειρηματικά μοντέλα βιωσιμότητας
subject: Στρατηγικές βιωσιμότητας
subject: Η οικονομία των πλαστικών
subject: Παραγωγή πλαστικών
subject: Μηδενικά απορρίμματα / απόβλητα

description: Η κυκλική οικονομία ολοένα και κερδίζει την προσοχή σε ότι αφορά την ανάπτυξη κοινωνικής και οικονομικής ευημερίας, μειώνοντας ταυτόχρονα την ζήτηση σε πεπερασμένες πρώτες ύλες και ελαχιστοποιώντας τις αρνητικές επιπτώσεις σε διαφορετικούς τομείς όπως περιβάλλον κλπ. Η μετάβαση αυτή απαιτεί μια συστημική προσέγγιση η οποία θα βοηθήσει σε βελτιώσεις του υπάρχοντος συστήματος καθώς επίσης θα δημιουργήσει και νέους μηχανισμούς συνεργασιών μεταξύ θεσμών. Στον ιδιωτικό τομέα οι επιχειρήσεις έρχονται αντιμέτωπες με την πρόκληση και ευκαιρία να επεκτείνουν τις δραστηριότητες τους και να δημιουργήσουν αξία μεταξύ αλυσίδων προμηθειών πρώτων υλών που παρουσιάζουν ελλείψεις και εγείρουν θέματα περιβαλλοντικών επιπτώσεων οδηγώντας κατά συνέπεια σε αύξηση τιμών και αβεβαιότητα. Το επιχειρηματικό μοντέλο κυκλικής οικονομίας θα συνεισφέρει στην απεξάρτηση ανάπτυξης από την εκμετάλλευση πόρων που τείνουν να εκλείψουν, και θα επιτρέψει την οικονομική ανάπτυξη μεταξύ ορίων φυσικών πόρων. Με τον τρόπο αυτό οι επιχειρήσεις θα έχουν την ευκαιρία να καινοτομήσουν επιτυγχάνοντας την βέλτιστη απόδοση προϊόντων και υπηρεσιών με τους ελάχιστους πόρους. Μια από τις κύριες προκλήσεις της μετάβασης στο οικονομικό μοντέλο κυκλικής οικονομίας είναι η εφαρμογή στρατηγικών κυκλικότητας στην βιομηχανία των πλαστικών. Η νέα οικονομία των πλαστικών σκοπεύει να ξεπεράσει τους περιορισμούς που θέτονται από μη οργανωμένες και σταδιακές πρωτοβουλίες μεταξύ ενδιαφερόμενων μερών. Σκοπός είναι να δημιουργήσει τις κατάλληλες κατευθυντήριες για την δημιουργία καινοτομίας και μετάβαση των αλυσίδων αξίας προς την μεγιστοποίηση οικονομικού κέρδους αλλά και βέλτιστων περιβαλλοντικών αποτελεσμάτων. Οι δυσκολίες αλλά και οι ευκαιρίες που προκύπτουν από τον σημερινό κύκλο ζωής των πλαστικών απαιτούν δραστικές αλλαγές στις οποίες η έρευνα και καινοτομία καθώς επίσης και η εφαρμογή των κατάλληλων θεσμικών πλαισίων, παίζουν καθοριστικό ρόλο. Ενώ τα πλαστικά αποτελούν ένα χρηστικό υλικό στο σημερινό σύστημα υπάρχουν σημαντικά μειονεκτήματα μεταξύ των οποίων οικονομικές απώλειες αξίας των υλικών, και περιβαλλοντικών επιπτώσεων. Είναι πλέον προφανές ότι η οικονομία των πλαστικών πρέπει να αλλάξει από ένα σύστημα που παράγει απορρίμματα βάση σχεδιασμού σε ένα σύστημα που διατηρεί στο μέγιστο την αξία και τα πλεονεκτήματα των πλαστικών. Η μακροπρόθεσμη λύση προς την επίτευξη της αλλαγής αυτής είναι μέσω πρωτοβουλιών καινοτομίας και έρευνας σε συνδυασμό με χάραξη πολιτικών που θα συνεισφέρουν αποτελεσματικά.
title: The Experiences of Staff Working with Vulnerable Populations
title: Racism, Power, and Psychological Impact: A Qualitative Analysis
titleType: Subtitle
Creators: name: Sandhu, Sharon Lilian
Publisher: name: Lancaster University
Year: 2024
Subjects: Domestic Violence
DV
Intimate Partner Violence
IPV
Staff experiences
Shelter
Racism
Homeless

description: This thesis is comprised of four sections: Section one: A systematic
 literature review that explored staff experiences of working in Domestic
 Violence (DV) shelters. With the use of thematic synthesis, nine papers
 were reviewed generating four analytical themes: emotional weight of the
 work, connecting with others, power versus empower, and making it through.
 Staff were found to face several challenges, including difficulties
 balancing resident wellbeing with their own, within a context of limited
 resources and wider systemic barriers. Findings highlighted a need for
 psychologically informed resources to reduce risk factors of burnout and
 Secondary Traumatic Stress (STS). Section two: An empirical research paper
 utilising a qualitative approach exploring staff experiences of racism
 within the homelessness sector. Seven female participants took part in the
 study and were interviewed using semi-structured interviews. Data was
 analysed using Reflexive Thematic Analysis (RTA) eliciting five themes:
 experiencing racism in blatant and subtle forms, powerlessness, feeling
 unheard and misunderstood, psychological impact, and perseverance and
 protection. The study highlighted the persistent nature of racism
 experienced by staff, including racial slurs, refusal to work with staff
 from ethnic minority communities, and a lack of acknowledgment of racism
 from those in senior positions. Findings illuminated a need for support
 for staff experiencing racism, along with raising awareness through
 interventions, such as training, for those without lived experience of
 racism. Section three: A critical appraisal offering an overview of
 findings, including bringing together the trauma impact staff experienced
 across both papers. Personal reflections discussed include the use of
 terminology selected, the impact of researcher insider status, along with
 discussion on clinical implications, strengths, and limitations of both
 studies. Section four: The empirical paper’s ethics application and
 supporting documents used in the process.
High rates of midazolam injection among drug users in Bangkok, Thailand
Creators: name: Kerr, Thomas
name: Kiatying-Angsulee, Niyada
name: Fairbairn, Nadia
name: Hayashi, Kanna
name: Suwannawong, Paisan
name: Kaplan, Karyn
name: Lai, Calvin
name: Wood, Evan
Publisher: name: BioMed Central
Year: 2015

description: Background: Reports from Thailand suggest that a growing number of people who inject drugs (IDU) are now injecting midazolam, a legal benzodiazepine with potent amnestic and ventilatory depressant effects. We therefore sought to examine midazolam injection among a community-recruited sample of Thai IDU. Methods We examined the prevalence and correlates of midazolam injection among 252 IDU participating in the Mitsampan Community Research Project, Bangkok, using multivariate logistic regression. We also examined the use of midazolam in combination with other drugs. Results 252 IDU participated in this study, including 66 (26.2%) women. In total, 170 (67.5%) participants reported ever having injected midazolam, and 144 (57.1%) reported daily midazolam injection in the past six months. In multivariate analyses, a history of midazolam injection was independently associated with using drugs in combination (adjusted odds ratio [AOR] = 5.86; 95% confidence interval [CI]: 2.96-11.60), younger age (AOR = 0.43; 95%CI: 0.22-0.83), having a history of methadone treatment (AOR = 3.12, 95%CI: 1.55-6.90), and binge drug use (AOR = 2.25, 95%CI: 1.09-4.63). The drugs most commonly used in combination with midazolam were heroin (72.3%) and yaba (methamphetamine) (30.5%). Conclusion We observed a high rate of midazolam injection among Thai IDU. Midazolam injection was strongly associated with polysubstance use and binge drug use, and was most commonly used in combination with both opiates and methamphetamines. Our findings suggest that midazolam injection has become increasingly common within Thailand. Evidence-based approaches for reducing harms associated with midazolam injection are needed.
Bedeutung der Lebensqualität und der Fragilität in der operativen Behandlung gynäkologischer Malignome
Creators: name: Inci, Melisa Gülhan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Frailty
subject: QoL
subject: gynecological cancer
subject: ovarian cancer
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Multidimensionale Aspekte wie Komorbiditäten, Lebensqualität, Ernährungszustand sowie anästhesiologische, perioperative und chirurgische Daten waren Bestandteil unserer bisherigen Forschungsarbeit. Der Ernährungszustand und die funktionelle Lebensqualität stellten sich als die wichtigsten Risikofaktoren für die erhöhte Morbidität und Mortalität heraus. In unseren Arbeiten konnten wir zeigen, dass neben dem FIGO-Stadium und dem ECOG-Status der präoperative Ernährungsstatus, einschließlich BMI und Phasenwinkel in der Bioimpedanzmessung, wichtige Indikatoren für schwere postoperative Komplikationen sind. Lebensqualität mit eingeschränkter körperlichen Funktion, Symptome wie Übelkeit und Erbrechen und reduzierte kognitive Funktion zeigten sich ebenfalls als signifikante Prädiktoren für schwere postoperative Komplikationen. Außerdem haben wir versucht die Gebrechlichkeit der Patientinnen evident zu quantifizieren und mögliche verbundene Risiken zu erkennen. Zur Quantifizierung der Gebrechlichkeit haben wir zwei neue Modelle, das physikalische phänotypische Modell und das kumulative Defizitmodell bei unseren Patientinnen untersucht. Den Frailty Index haben wir modifiziert für unsere gynäkologischen Patientinnen und konnten zeigen, dass gebrechliche Patientinnen mit einem Frailty Index> 0,26 5-fach höheres Risiko für schwere postoperative Komplikationen hatten. Das physikalische Phänotyp Model nach Fried zeigte hingegen keine signifikante Korrelation mit den schweren postoperativen Komplikationen in unserer Kohorte. Die Herausforderung besteht darin, ein zuverlässiges und praktisches Vorhersagemodell für schwere postoperative Komplikationen zu entwickeln, das eine umfassende präoperative Beurteilung mit einem mehrdimensionalen Ansatz für die Patientin umfasst.
Unified Wave Integration Theory (UWIT): A Framework for Consciousness and Emergent Properties in Organic and Non-Organic Systems
Creators: name: Sambey, Stanley Everett
Publisher: name: Zenodo
Year: 2025

description: The Unified Wave Integration Theory (UWIT) proposes that all measurable phenomena—acoustic,electromagnetic, gravitational, and neural—are wave-based systems governed by a unified mathematicalstructure. This paper extends UWIT to explain the emergence of consciousness and other properties in**organic systems** (e.g., cells, organisms) compared to **non-organic systems** (e.g., rocks, metals).By analyzing wave dynamics, nonlinear feedback, and binding mechanisms, UWIT provides a quan-titative framework for understanding the transition from non-living to living systems. The theory issupported by testable predictions and has implications for biology, artificial intelligence, and philosophy.
Kolloquium der Südostasien-Stipendiaten der Stiftung Volkswagenwerk vom 13. und 14. Mai 1982 in Hannover
Creators: name: Gura, Susanne
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: ASIEN: The German Journal on Contemporary Asia, Nr. 5 (1982): ASIEN (Oktober)
Cyclic Cohomology and Geometric Invariants ofGroupoid C*-Algebras
Creators: name: Polozov, Andrei
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 490107
subject: Mathematical methods and special functions

description: We study the cyclic cohomology of geometric C*-algebras associated with smoothgroupoids, foliated manifolds, and noncommutative spaces arising from dynamicsand arithmetic. Cyclic cohomology, developed by Connes, generalizes de Rham co-homology and provides tools to extract invariants from noncommutative algebras,particularly when classical geometry breaks down.We begin with explicit cocycles on the smooth circle algebra C∞(S1), connectingthem to K-theoretic winding numbers.
Unified Wave Integration Theory (UWIT): A Framework for Consciousness and Emergent Properties in Organic and Non-Organic Systems
Creators: name: Sambey, Stanley Everett
Publisher: name: Zenodo
Year: 2025

description: The Unified Wave Integration Theory (UWIT) proposes that all mea-surable phenomena—acoustic, electromagnetic, gravitational, and neu-ral—are wave-based systems governed by a unified mathematical struc-ture. This paper extends UWIT to explain the emergence of consciousnessand other properties in organic systems (e.g., cells, organisms) com-pared to non-organic systems (e.g., rocks, metals). By analyzing wavedynamics, nonlinear feedback, and binding mechanisms, UWIT providesa quantitative framework for understanding the transition from non-livingto living systems. The theory is supported by testable predictions and hasimplications for biology, artificial intelligence, and philosophy.
THE BENEFITS OF PSYCHEDELIC THERAPY FOR MENTAL HEALTH: EXPLORING PSYCHEDELICS
Creators: name: Irizabal, Liliana
Publisher: name: Zenodo
Year: 2022
Subjects: systematic review
psychedelics
therapy
mental health
mental disorders

description: This project is a systematic review that highlights how beneficial psychedelic psychotherapy can be to those suffering with mental illness. The three mental illnesses chosen to be analyzed in the literature were depression, post-traumatic stress disorder (PTSD), and anxiety. The drugs used in the specific articles included Psilocybin, Ayahuasca(DMT), and MDMA (3,4-methylenedioxymethamphetamine; ecstasy or molly). The analyzed literature discussed trials regarding psychotherapy and how these specific psychedelics affected specific mood disorders, including anxiety, depression, and PTSD. Significant data showed positive effects of these psychedelics with specific mood disorders. Psilocybin and DMT were seen to be helpful with anxiety and depression, and those levels were decreased when these two psychedelics were administered in specific doses. MDMA was seen to have positive effects on PTSD by decreasing the symptoms of the disorder. Although research is limited and more studies on the topic must be conducted, the published research show promising results, and it is important to further research the impact of psychedelic psychotherapy.
Ανάλυση δεδομένων COVID-19 με Συστήματα Γεωγραφικών Πληροφοριών
Creators: name: Χατζηδιάκου, Ελένη
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Μεγάλα δεδομένα
subject: COVID-19
subject: Συστήματα Γεωγραφικών Πληροφοριών

description: Σε αυτή την εργασία θα μελετήσουμε τη γεωγραφική εξάπλωση του κορονοϊού. Ως πηγή δεδομένων για τον κορονοϊό είναι οι περιπτώσεις μολύνσεων και θάνατοι ανά ημέρα. Έχουν χρησιμοποιηθεί δεδομένα που περιέχουν αυτή τη στιγμή περίπου 60000 εγγραφές, οπότε είναι κατάλληλα για εφαρμογή τεχνικών ανάλυσης μεγάλων δεδομένων. Ακόμα μελετήθηκαν χωρικά δεδομένα όπως για παράδειγμα κάποια βασικά γεωγραφικά και οικονομικά δεδομένα ανά χώρα (τύπου πληθυσμός, πυκνότητα, ΑΕΠ κλπ) και δημογραφικά δεδομένα (πληθυσμός, πυκνότητα, ηλικία κλπ) για το 2020. Επιπλέον, αναλύονται χωρικά δεδομένα διαφορετικού τύπου, όπως για παράδειγμα σχετικά με τον καιρό (π.χ. θερμοκρασία, βροχή). Τα μετεωρολογικά δεδομένα είναι για το 2020. Τα παραπάνω δεδομένα θα συνδυαστούν και θα αποτελέσουν χαρακτηριστικά προς ταξινόμηση. Η μεταβλητή στόχος θα είναι η ημερήσια αύξηση του κορονοϊού. Θα χωρίσουμε την αύξηση σε διακριτές κατηγορίες. Στη συνέχεια θα εκπαιδεύσουμε διάφορους αλγορίθμους, για παράδειγμα K-nearest-neighbors, SVM (support vector machines), δέντρα αποφάσεων (Decision Tree) και Τυχαίο Δάσος (Random Forest). Θα γίνει 10-fold cross-validation, ώστε να χωρίσουμε τα δεδομένα σε υποσύνολα εκπαίδευσης και δοκιμής. Επίσης, θα δοκιμάσουμε διάφορες παραμέτρους, ώστε να βελτιστοποιήσουμε τα αποτελέσματα του κάθε αλγορίθμου. Με βάση τα δεδομένα δοκιμής θα αξιολογήσουμε τους ταξινομητές με διάφορες μετρικές, όπως η ακρίβεια, η ευαισθησία και η εξειδίκευση για να δούμε ποιος αλγόριθμος δίνει το καλύτερο αποτέλεσμα. Tα γεωγραφικά δεδομένα για τον κορονοϊό που συγκεντρώθηκαν προηγουμένως θα γίνει απεικόνισή τους σε χάρτη. Επίσης, μπορεί να γίνει απεικόνιση σε χάρτη της συσχέτισης των οικονομικών, δημογραφικών και μετεωρολογικών δεδομένων με την εξάπλωση του ιού. Λαμβάνοντας υπόψη τη φύση των δεδομένων, η ανάλυση και η απεικόνιση θα γίνει ανά χώρα.
Kampuchea: Patterns of Factional Conflict and International Confrontation
Creators: name: Kroef, Justus M. Van Der
Publisher: name: Asien
Year: 2020

description: On December 5, 1981, the Central Committee of the Kampuchean People's Revolutionary Party (KPRP), the organizational matrix of the Hanoi-imposed and -supported People’s Republic of Kampuchea (PRK) headed by President Heng Samrin, announced at the close of its "second ordinary meeting" held in Phnom Penh, that Pen Sovan, the KPRP's secretary general and chairman (i.e. premier) of the Republic's Council of Ministers, had "been permitted to take a long rest in order to cure himself from illness." Though subsequently PRK diplomats affirmed that Sovan really was "seriously ill," allegedly suffering from heart and nervous system ailments, informed sources agreed that Sovan's resignation had been forced and reflected a power struggle within the KPRP and PRK leadership. Indeed, by March, 1982, diplomatic observers in Bangkok believed Sovan to be in Hanoi, being held under house arrest. Sovan was said to have run afoul of his avowedly pro-Moscow political orientation which increasingly had begun to irk the Vietnamese. The latter maintain a 200,000-man military force in that part of Kampuchean territory that is under the PRK's control, and an estimated 5,000 civilian Vietnamese officials and party cadres "assist" and "advise" in the day-to-day operations of the PRK government.
description: Asien, Nr. 5 (1982): ASIEN (Oktober)
V. Parteitag der Kommunistischen Partei Vietnams im Zeichen der Spaltung innerhalb der Führung
Creators: name: The, Au Duong
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Vor über fünf Jahren versprach die Führung der kommunistischen Partei Vietnams (hinfort KPV) auf dem IV. Parteitag im Dezember 1976 einen schnellen Wiederaufbau des Landes. Vietnam genoß damals großes Ansehen bei seinen Freunden und Respekt bei seinen Feinden. Jetzt steht das Land vor dem wirtschaftlichen Chaos und der außenpolitischen Isolierung. Es befindet sich in einem Zustand zunehmender Unregierbarkeit. Die Parteizentrale ist gespalten wie nie zuvor.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 5 (1982): ASIEN (Oktober)
Indian Ocean: The ’’Peace Zone" Paradox and Chances for Areas of Peace
Creators: name: Braun, Dieter
Publisher: name: Asien
Year: 2020

description: The term ’zone of peace' is sufficiently vague and imprecise to serve the most divergent political purposes. As ’peace’, moreover, signifies a supreme moral/political value, neither individual nor state could straight-away oppose something that is being proclaimed in its name. The Soviet Union has made early and frequent political use of this quality. Thus Khrushchev, while taking up an old guide-line by Lenin about "the peoples of the East”, demanded at the XX. party congress (1956) the creation of a peace zone, consisting of both the socialist camp and the newly emerging Asian and African states; this was the fore runner to later Soviet claims of being the partner in a 'natural alliance’ with the Third World. Even earlier (in 1955), Nehru had equalled an 'area of peace’ with the non-aligned countries between East and West; they should, by their equidistance, limit the dangers of war between the competing blocs. This was the year of Bandung.
description: Asien, Nr. 5 (1982): ASIEN (Oktober)
Paradigmenwechsel in der Klassifikation und Diagnostik neuropathologischer Tumoren durch neue molekulare Methoden
Creators: name: Schweizer, Leonille
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: methylation analysis
subject: cauda equina paraganglioma
subject: subependymoma
subject: solitary fibrous tumor
subject: BRAF mutation
subject: next-generation sequencing
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die methylierungsbasierte Klassifikation von Hirntumoren hat zu einer tiefgreifenden Veränderung unserer Betrachtungsweise neuropathologischer Tumoren geführt, die sich auch in der kommenden, neuen WHO Klassifikation in Form integrierter, molekularer Diagnosen niederschlägt. Der Paradigmenwechsel durch neue molekulare Methoden hat sich jedoch auch essentiell auf den Arbeitsalltag und die Routineabläufe in neuropathologischen Instituten ausgewirkt, ebenso wie auf die Art der Befundung, das Selbstverständnis als Diagnostiker und die Ausbildung junger Neuropathologen. Die Arbeit zeigt anhand ausgewählter, konkreter Beispiele wie sich wissenschaftliche Fragestellungen und Herangehensweisen, aber auch Verständnis und Implementierung von Ergebnissen vor, während und nach der epigenetischen Revolution im Bereich der Hirntumordiagnostik verändert haben. Während vor Einführung der Methylierungsanalysen histologisch definierte Hirntumorentitäten Ausgangpunkt für explorative, genetische Untersuchungen waren, wie dies in der ersten Arbeit anhand der papillären Kraniopharyngeome und in der zweiten Arbeit anhand der solitär fibrösen Tumoren und Hämangioperizytomen gezeigt wird, repräsentiert die dritte Arbeit einen diagnostischen Meilenstein in der Hirntumordiagnostik und weist auf das transformierende Potential einer morphologie-unabhängigen, auf epigenetischen Signaturen beruhenden und durch bioinformatische Analysen erst nutzbaren Klassifikation von ZNS Tumoren für die Routinediagnostik und Forschung hin. Die vierte Arbeit zeigt am Beispiel der ZNS Paragangliome, wie sich durch die Anwendung der epigenetischen Analysen neue, molekular definierte Entitäten abgrenzen lassen. In der fünften Arbeit wird am Beispiel ependymaler Tumoren mit dem epigenetischen Profil der Methylierungsklasse „Subependymom, posterior fossa“ gezeigt, dass sich innerhalb einer nun epigenetisch definierter Tumorentität molekulare Risikogruppen identifizieren lassen, die charakteristische, genetische Veränderungen aufweisen, deren routinemäßige Bestimmung möglicherweise zu einer verbesserten Patienten-Stratifizierung in zukünftigen Studien beitragen könnte.
Piloting maDMPs for Streamlined Research Data Management Workflows
Creators: name: Praetzellis, Maria
name: Grady, Becky
name: Taylor, Shawna
Publisher: name: Zenodo
Year: 2025
Subjects: Curation infrastructure: Tools, systems and services that are in development
Curation infrastructure: Proposals for new approaches to large-scale service delivery
Curation infrastructure: Innovative research and exploration into new curation methods
RDM
Machine-actionable DMP
Data sharing
IDCC25
Lightning Talks

description: In response to the growing federal mandates for data management and sharing, the California Digital Library (CDL) and the Association of Research Libraries (ARL) have launched a pilot project to test new workflows at 10 U.S. universities. The project utilizes machine-actionable DMPs (maDMPs) to streamline processes, improve communication, and ensure compliance with federal requirements. This lightning talk will discuss the pilot by exploring three case studies that showcase the use of generative AI for crafting compliant data management plans, maDMPs for deploying computing and storage resources, and tracking research outputs through integration with internal data management platforms.
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus
Creators: name: Kim, Yun B
name: Ryu, Jae K
name: Lee, Hong J
name: Lim, In J
name: Park, Dongsun
name: Lee, Min C
name: Kim, Seung U
Publisher: name: BioMed Central
Year: 2016

description: Background: Midkine (MK), a member of the heparin-binding growth factor family, which includes MK and pleiotrophin, is known to possess neurotrophic and neuroprotective properties in the central nervous system. Previous studies have shown that MK is an effective neuroprotective agent in reducing retinal degeneration caused by excessive light and decreasing hippocampal neuronal death in ischemic gerbil brain. The present study was undertaken to investigate whether MK acts as an anticonvulsant in kainic acid (KA)-induced seizure in mouse and blocks KA-mediated neuronal cell death in hippocampus. Results: Increased expression of MK was found in hippocampus of mouse following seizures induced by intracerebroventricular injection of KA, and MK expression was found in glial fibrillary acidic protein (GFAP)-positive astrocytes. Concurrent injection of MK and KA attenuated KA-induced seizure activity and cell death of hippocampal neurons including pyramidal cells and glutamic acid decarboxylase 67 (GAD67)-positive GABAergic interneurons in the CA3 and hilar area. Conclusion: The results of the present study indicate that MK functions as an anticonvulsant and neuroprotective agent in hippocampus during KA-induced seizures.
Twenty Years Back, Five Years Forward: The Past, Present and Future of DANS
Creators: name: Dillo, Ingrid
Publisher: name: Zenodo
Year: 2025
Subjects: IDCC25
Curation infrastructure: Tools, systems and services that are in development
Digitisation
Data infrastructure
FAIR
Open Science
Trustworthy repository
Lightning Talks

description: The first IDCC took place in 2005. In that same year, the Dutch national research funder and the Royal Academy of Arts and Sciences created a new organization called DANS with a mission to preserve and guarantee continued access to research data in the humanities and social sciences.

Twenty years later DANS has become the Dutch national centre of expertise and repository for research data, with a mission to enhance the reusability of research data and thus the quality of scientific research. And what will the future bring for DANS? We are currently working on our strategy for the coming years.

In this presentation I will give a concise overview of the DANS organization and services as well as the main developments in its environment, in the past (2005), present (2025) and future (2030). This will show that the environment in which DANS is positioned changed dramatically over the last twenty years, with the rapid development of the digital world, the arrival of the Open Science and FAIR concepts and the unprecedented impact of AI. On the other hand we will see that a lot of the challenges that were identified in 2005 still exist.
Strategy for Open Science Development at Berdyansk State Pedagogical University
Creators: name: Suchikova, Yana
name: Nazarovets, Serhii
Publisher: name: Zenodo
Year: 2025
Subjects: subject: open science
subject: Open Access Publishing
subject: Open Access Publishing/ethics
subject: Open Access Publishing/standards
subject: Open Access Publishing/organization & administration
subject: research data
subject: research data management
subject: FAIR
subject: CARE
subject: scholarly communication
subject: open science policy

description: This document defines the key approaches to implementing open science at Berdyansk State Pedagogical University (BSPU). It outlines strategic goals, core principles, and mechanisms for open science implementation, including support for open access, research data management, integration of FAIR and CARE principles, responsible research assessment, and the development of digital infrastructure.

This strategy is part of BSPU’s Open Science Policy, which includes three key components:

Open Science Development Strategy – defines the mission, vision, strategic goals, and principles of open science implementation.

Policy Implementation Roadmap – describes implementation stages, tasks, key performance indicators (KPIs), resources, and monitoring mechanisms.

Action Plan – details short-term measures necessary to achieve the defined goals.

The strategy aligns with national and international initiatives, including Ukraine’s National Open Science Plan, the European Open Science Cloud (EOSC) principles, the Barcelona Declaration, the San Francisco Declaration on Research Assessment (DORA), and the Hong Kong Principles for Assessing Researchers.

This document is a pilot version designed for a one-year period, after which its implementation results will be analyzed to develop a long-term open science policy for the university.
Neubelebung der Pancasila
Creators: name: Schweizer, Peter A.
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2020

description: Als sich im Frühling 1945 der japanische Rückzug aus Südostasien mit zunehmender Deutlichkeit ankündigte, setzte die Okkupationsmacht in Indonesien noch rasch ein Komitee ein, das die Entlassung der ehemals niederländischen Kolonie in die Unabhängigkeit im Rahmen einer japanischen "Prosperitätszone" allerdings vorbereiten sollte. Doch den fremden Herren war bereits der Atem so sehr ausgegangen, daß die von ihnen einberufenen Staatsgründer nicht der vorgelegten Traktandenliste, sondern eigenem Gutdünken zu folgen wagten. "Wie soll denn unsere zukünftige Staatsgrundlage aussehen?" so formulierte am 29. Mai 1945 der Vorsitzende die Kernfrage der künftigen Debatte, die auf japanische Hegemoniewünsche herzlich wenig Bezug nehmen sollte.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 14 (1985): ASIEN (Januar)
Highly Efficient Stable Expression of Indoleamine 2,3 Dioxygenase Gene in Primary Fibroblasts
Creators: name: Moeen Rezakhanlou, Alireza
name: Habibi, Darya
name: Lai, Amy
name: B. Jalili, Reza
name: Ong, Christopher J.
name: Ghahary, Aziz
Publisher: name: BioMed Central
Year: 2015

description: Indoleamine 2,3 dioxygenase (IDO) is a potent immunomodulatory enzyme that has recently attracted significant attention for its potential application as an inducer of immunotolerance in transplantation. We have previously demonstrated that a collagen matrix populated with IDO-expressing fibroblasts can be applied successfully in suppressing islet allogeneic immune response. Meanwhile, a critical aspect of such immunological intervention relies largely on effective long-term expression of the IDO gene. Moreover, gene manipulation of primary cells is known to be challenging due to unsatisfactory expression of the exogenous gene. In this study, a lentiviral gene delivery system has been employed to transduce primary fibroblasts. We used polybrene to efficiently deliver the IDO gene into primary fibroblasts and showed a significant increase (about tenfold) in the rate of gene transfection. In addition, by the use of fluorescence-activated cell sorting, a 95% pure population of IDO-expressing fibroblasts was successfully obtained. The efficiency of the IDO expression and the activity of the enzyme have been confirmed by Western blotting, fluorescence-activated cell sorting analysis, and Kynurenine assay, respectively. The findings of this study revealed simple and effective strategies through which an efficient and stable expression of IDO can be achieved for primary cells which, in turn, significantly improves its potential as a tool for achieving immunotolerance in different types of transplantation.