cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
Creators: name: Heyder, Nicolas A.
name: Kleinau, Gunnar
name: Speck, David
name: Schmidt, Andrea
name: Paisdzior, Sarah
name: Szczepek, Michal
name: Bauer, Brian
name: Koch, Anja
name: Gallandi, Monique
name: Kwiatkowski, Dennis
name: Bürger, Jörg
name: Mielke, Thorsten
name: Beck-Sickinger, Annette G.
name: Hildebrand, Peter W.
name: Spahn, Christian M. T.
name: Hilger, Daniel
name: Schacherl, Magdalena
name: Biebermann, Heike
name: Hilal, Tarek
name: Kühnen, Peter
name: Kobilka, Brian K.
name: Scheerer, Patrick
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Cell signalling
subject: Cryoelectron microscopy
subject: setmelanotide
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity. Here, we present cryo-electron microscopy structures of MC4R–Gs-protein complexes with two drugs recently approved by the FDA, the peptide agonists NDP-α-MSH and setmelanotide, with 2.9 Å and 2.6 Å resolution. Together with signaling data from structure-derived MC4R mutants, the complex structures reveal the agonist-induced origin of transmembrane helix (TM) 6-regulated receptor activation. The ligand-binding modes of NDP-α-MSH, a high-affinity linear variant of the endogenous agonist α-MSH, and setmelanotide, a cyclic anti-obesity drug with biased signaling toward Gq/11, underline the key role of TM3 in ligand-specific interactions and of calcium ion as a ligand-adaptable cofactor. The agonist-specific TM3 interplay subsequently impacts receptor–Gs-protein interfaces at intracellular loop 2, which also regulates the G-protein coupling profile of this promiscuous receptor. Finally, our structures reveal mechanistic details of MC4R activation/inhibition, and provide important insights into the regulation of the receptor signaling profile which will facilitate the development of tailored anti-obesity drugs.
Liquid Democracy in DPoS Blockchains
Creators: name: Li, Chao
name: Xu, Runhua
name: Duan, Li
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Voting mechanisms play a crucial role in decentralized governance of blockchain systems. Liquid democracy, also known as delegative voting, allows voters to vote directly or delegate their voting power to others, thereby contributing to the resolution of problems such as low voter turnout. In recent years, liquid democracy has been widely adopted by Delegated-Proof-of-Stake (DPoS) blockchains and implemented successfully on platforms with millions of users. However, little is known regarding the characteristics and actual effectiveness of liquid democracy in decentralized governance. This paper explored for the first time the practical implementation of liquid democracy in DPoS blockchain systems. Using actual data collected from two major DPoS blockchains, EOS and Steem, our study compared and evaluated the participation of different types of users of DPoS blockchain systems in liquid democracy, as well as extracting and analyzing the delegation chains and networks formed during the process of liquid democracy within the systems. We believe that the findings of this paper will contribute to further studies on the design and implementation of liquid democracy and other voting mechanisms in decentralized governance.
The Supernova Progenitor Mass Distributions of M31 and M33: Further Evidence for an Upper Mass Limit
Creators: name: Jennings, Zachary G.
name: Williams, Benjamin F.
name: Murphy, Jeremiah W.
name: Dalcanton, Julianne J.
name: Gilbert, Karoline M.
name: Dolphin, Andrew E.
name: Weisz, Daniel R.
name: Fouesneau, Morgan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using Hubble Space Telescope (HST) photometry to measure star formation histories, we age-date the stellar populations surrounding supernova remnants (SNRs) in M31 and M33. We then apply stellar evolution models to the ages to infer the corresponding masses for their supernova progenitor stars. We analyze 33 M33 SNR progenitors and 29 M31 SNR progenitors in this work. We then combine these measurements with 53 previously published M31 SNR progenitor measurements to bring our total number of progenitor mass estimates to 115. To quantify the mass distributions, we fit power laws of the form $dN/dM \propto M^{-α}$. Our new, larger sample of M31 progenitors follows a distribution with $α= 4.4\pm 0.4$, and the M33 sample follows a distribution with $α= 3.8^{+0.4}_{-0.5}$. Thus both samples are consistent within the uncertainties, and the full sample across both galaxies gives $α= 4.2\pm 0.3$. Both the individual and full distributions display a paucity of massive stars when compared to a Salpeter initial mass function (IMF), which we would expect to observe if all massive stars exploded as SN that leave behind observable SNR. If we instead fix $α= 2.35$ and treat the maximum mass as a free parameter, we find $M_{max} \sim 35-45M_{sun}$, indicative of a potential maximum cutoff mass for SN production. Our results suggest that either SNR surveys are biased against finding objects in the youngest (<10 Myr old) regions, or the highest mass stars do not produce SNe.
description: 12 pages, 4 figures, 3 tables, accepted to ApJ
Usability and Acceptance of Exergames Using Different Types of Training among Older Hypertensive Patients in a Simulated Mixed Reality
Creators: name: Stamm, Oskar
name: Vorwerg, Susan
name: Haink, Michele
name: Hildebrand, Kristian
name: Buchem, Ilona
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: virtual reality
subject: hypertension
subject: rehabilitation
subject: UX
subject: presence
subject: immersion
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Virtual and augmented reality (VR/AR) exergames are promising tools for increasing training motivation. However, the use of exergames with mixed reality (MR) headsets remains under-researched. Older adults with hypertension could also benefit from the increased training adherence associated with MR. Endurance and strength endurance exercises are recommended for this group to lower blood pressure. The aim of the preliminary study (n = 22) was to compare the usability and acceptance of two exergames, which represent two different training types-strength endurance training (SET) and endurance training (ET). The developed exergame prototypes were applied in "simulated MR" using a VR head-mounted display. We examined the following outcomes: usability (TUI), intention to use (TUI), subjective task load (NASA-TLX), frustration (NASA-TLX), and presence (PQ). The results showed that frustration was significantly greater in the ET than in the SET (p = 0.038). Presence was significantly higher in the SET (p = 0.002). No significant differences in usability and acceptance were found in the exergames. The results indicate that usability and acceptance are not related to the type of training when utilizing MR exergames. Whether the results are transferable with a real MR headset must be determined in further research.
Peculiar Glitch of PSR J1119-6127 and Extension of the Vortex Creep Model
Creators: name: Akbal, O.
name: Gügercinoğlu, E.
name: Muş, S. Şaşmaz
name: Alpar, M. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Glitches are sudden changes in rotation frequency and spin-down rate, observed from pulsars of all ages. Standard glitches are characterized by a positive step in angular velocity ($ΔΩ$ $ > $ $0$) and a negative step in the spin-down rate ($Δ\dot Ω$ $ < $ $0$) of the pulsar. There are no glitch-associated changes in the electromagnetic signature of rotation-powered pulsars in all cases so far. For the first time, in the last glitch of PSR J1119-6127, there is clear evidence for changing emission properties coincident with the glitch. This glitch is also unusual in its signature. Further, the absolute value of the spin-down rate actually decreases in the long term. This is in contrast to usual glitch behaviour. In this paper we extend the vortex creep model in order to take into account these peculiarities. We propose that a starquake with crustal plate movement towards the rotational poles of the star induces inward vortex motion which causes the unusual glitch signature. The component of the magnetic field perpendicular to the rotation axis will decrease, giving rise to a permanent change in the pulsar external torque.
description: accepted by MNRAS, 10 pages, 2 figures
A bibliometric analysis of clinical research on fracture-related infection
Creators: name: Li, Cheng
name: Foster, Andrew L.
name: Han, Nicholas Hang Bao
name: Trampuz, Andrej
name: Schuetz, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: orthopaedic trauma surgery
subject: fracture-related infection (FRI)
subject: bibliometric analysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Infection following orthopaedic trauma surgery is increasingly recognized as one of the major research priorities with as primary goal, improving patient care. This increased interest has been anecdotally recognized through published research, research grants, and, finally, with the development of the fracture-related infection (FRI) consensus group. In 2017, the accepted consensus definition of FRI was published, which has been followed by consensus recommendations from both a surgical and medical perspective. A bibliometric analysis was performed to objectively describe the trends in published clinical research related to FRI. Methods: The terms related to FRI were searched in the Web of Science database between 2000 and 2020. The characteristics of clinical research on FRI regarding the author, country, journal, institution, scientific output, top 100 most cited articles, and trend topics were analyzed using Bibliometrix and WPS Office. Results: A total of 2597 records were eligible for inclusion in this bibliometric approach, with studies originating from 89 countries, including eight languages. The United States of America (USA) published the highest number of articles and citations. International collaborations were present between 72 countries, with the most active country being the USA. The most contributive institution was the University of California. The highest number of papers and citations were from the Injury-International Journal of the Care of the Injured and the Journal of Orthopaedic Trauma. The top 100 most cited articles were published in 27 different journals, with the number of citations ranging between 97 and 1004. The latest trend topics were related to the diagnosis of FRI. Conclusion: The present bibliometric analysis shows the research characteristics and trends of FRI from multiple perspectives. The fact that there is an increasing number of studies being published on FRI shows the agreement among scientists and clinicians that standardization with respect to this topic is very important.
How to Search for Islands of Neutral Hydrogen in the $z \sim 5.5$ IGM
Creators: name: Malloy, Matthew
name: Lidz, Adam
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Observations of the Lyman-alpha (Ly-$α$) forest may allow reionization to complete as late as $z \sim 5.5$, provided the ionization state of the intergalactic medium (IGM) is sufficiently inhomogeneous at these redshifts. In this case, significantly neutral islands may remain amongst highly ionized gas with the ionized regions allowing some transmission through the Ly-$α$ forest. This possibility has the important virtue that it is eminently testable with existing Ly-$α$ forest data. In particular, we describe three observable signatures of significantly neutral gas in the $z \sim 5.5$ IGM. We use mock quasar spectra produced from numerical simulations of reionization to develop these tests. First, we quantify how the abundance and length of absorbed regions in the forest increase with the volume-averaged neutral fraction in our reionization model. Second, we consider stacking the transmission profile around highly absorbed regions in the forest. If and only if there is significantly neutral gas in the IGM, absorption in the damping wing of the Ly-$α$ line will cause the transmission to recover slowly as one moves from absorbed to transmitted portions of the spectrum. Third, the deuterium Ly-$β$ line should imprint a small but distinctive absorption feature slightly blueward of absorbed neutral regions in the Ly-$β$ forest. We show that these tests can be carried out with existing Keck HIRES spectra at $z \sim 5.5$, with the damping wing being observable for $< x_{\text{HI}} >\gtrsim 0.05$ and the deuterium feature observable with additional high-resolution spectra for $< x_{\text{HI}} >\gtrsim 0.2$.
description: 19 pages, 13 figures
Land Purchases and Acquisitions, 1975-77 -- A Report on a Landownership Follow-on Survey
Creators: name: Moyer, D. David.
name: Daugherty, Arthur B.
name: Moyer, D. David.
name: Daugherty, Arthur B.
Publisher: name: Unknown
Year: 1982
Subjects: subject: Agricultural Finance
subject: Farm Management
subject: Land Economics/Use
subject: Land purchases
subject: land acquisitions
subject: land transfers
subject: purchase price
subject: land financing
subject: loans
subject: land use

description: Of the estimated 34 million owners of land in the United States on January 1, 1978, 3.3 million purchased or acquired 5.2 million parcels containing 112.5 million acres between 1975 and 1977. About 18 percent of the acres were acquired from relatives, by purchase or inheritance. Buyers incurred transfer costs of $1.8 billion, or $1,464 per parcel acquired. An estimated one-sixth of the owners acquired the land in a cash deal, and another 43 percent said they obtained financing from a commercial bank or savings and loan. Mortgages averaged 22 years in length and carried an average interest rate of 8.3 percent. One percent of the land acquired was changed from cropland to noncropland, and 4 percent was changed from noncropland to cropland. Over one-third of the land acquired was to be operated as a separate farm and one-fourth was added to existing farms.
The Multiplicity of Massive Stars: A High Angular Resolution Survey with the HST Fine Guidance Sensor
Creators: name: Aldoretta, E. J.
name: Caballero-Nieves, S. M.
name: Gies, D. R.
name: Nelan, E. P.
name: Wallace, D. J.
name: Hartkopf, W. I.
name: Henry, T. J.
name: Jao, W. -C.
name: Apellániz, J. Maíz
name: Mason, B. D.
name: Moffat, A. F. J.
name: Norris, R. P.
name: Richardson, N. D.
name: Williams, S. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the results of an all-sky survey made with the Fine Guidance Sensor on Hubble Space Telescope to search for angularly resolved binary systems among the massive stars. The sample of 224 stars is comprised mainly of Galactic O- and B-type stars and Luminous Blue Variables, plus a few luminous stars in the Large Magellanic Cloud. The FGS TRANS mode observations are sensitive to detection of companions with an angular separation between 0."01 and 1."0 and brighter than $\triangle m = 5$. The FGS observations resolved 52 binary and 6 triple star systems and detected partially resolved binaries in 7 additional targets (43 of these are new detections). These numbers yield a companion detection frequency of 29% for the FGS survey. We also gathered literature results on the numbers of close spectroscopic binaries and wider astrometric binaries among the sample, and we present estimates of the frequency of multiple systems and the companion frequency for subsets of stars residing in clusters and associations, field stars, and runaway stars. These results confirm the high multiplicity fraction, especially among massive stars in clusters and associations. We show that the period distribution is approximately flat in increments of log P. We identify a number of systems of potential interest for long term orbital determinations, and we note the importance of some of these companions for the interpretation of the radial velocities and light curves of close binaries that have third companions.
description: 37 pages, 4 figures, 5 tables; AJ, in press; Full version with extended tables and large figure set can be found: http://www.astro.umontreal.ca/~emily/fgs.pdf
The First Neuropalliative Care Unit in Germany—Characteristics of Patients
Creators: name: Willert, Anna-Christin
name: Meyerling, Johanna
name: Ploner, Christoph J.
name: Kowski, Alexander B.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: neuropalliative care
subject: palliative care needs
subject: palliative care
subject: neurology
subject: brain tumor
subject: neurodegenerative disease
subject: cerebrovascular diseases
subject: palliative care unit
subject: neuropalliative care unit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: A unique structure of care for neurological inpatients with significant palliative care (PC) needs was established in the Department of Neurology at the Charite-Universitatsmedizin Berlin in 2021: a specialized neuropalliative care (NPC) unit. After one year, we provide an overview of the concept and the patients' characteristics. Methods: We retrospectively analyzed the characteristics of patients treated in our NPC unit between February 2021-February 2022. Data were extracted from medical records and PC assessment including diagnosis, mode of admission and discharge, length of stay, and palliative symptoms. Data are presented as averages with a 95% confidence interval [lower limit; upper limit] or percentage (absolute number). Results: We included 143 patients (52% (75) female, 67.9 years [65.6; 70.2]). Patients were admitted from general wards (48%; 68), their homes (22%; 32), intensive care units (16%; 23) or emergency departments (14%; 20). The main diagnoses were tumors of the nervous system (39%; 56), neurodegenerative diseases (30%; 43), neurologic complications (13%; 19) and cerebrovascular diseases (12%; 17). Complaints most frequently rated as severely to overwhelmingly burdensome were motor- or fatigue-associated problems, problems communicating, dysphagia and pain. The average length of stay was 13.7 days [12.2; 15.2]. Forty-five percent (64) of patients were discharged without further PC, 17% (24) were referred to a hospice and 13% (18) were discharged with outpatient PC. Five percent (7) were referred to neurorehabilitation and 21% (30) of patients died. Conclusions: Our NPC unit is a new model of care for neurological patients with substantial PC needs especially within the structures of a highly specialized and individualized medicine.
A clustering analysis of energy and water consumption in US states from 1985 to 2015
Creators: name: Kapousouz, Evgenia
name: Seyrfar, Abolfazl
name: Derrible, Sybil
name: Ataei, Hossein
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering
subject: 90509 Water Resources Engineering

description: Energy and water are critical resources, and virtually every activity that people engage in involves at least one of the two. The overall demand for energy and water in the United States has been increasing, partly as a result of population growth and changing climate conditions. In this study, we examine per capita water and energy consumption from 1985 to 2015 in all 50 states of the United States and the District of Columbia. The analysis is conducted first separately for water and energy consumption and then in a combined manner to identify the main trends and changes over the years. To further account for regional climate conditions, energy consumption data is also standardized using heating and cooling degree days. Line graphs, clustering analysis, and GIS mapping were used to analyze the data. Overall, we find that water use per capita has decreased over the years, while mixed results are found for energy consumption per capita. Moreover, some states do not show significant differences in water use or energy consumption, while others differ significantly. In general, we find that states can be clustered in five to six groups.
The effect of starspots on the ages of low-mass stars determined from the lithium depletion boundary
Creators: name: Jackson, R. J.
name: Jeffries, R. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In a coeval group of low-mass stars, the luminosity of the sharp transition between stars that retain their initial lithium and those at slightly higher masses in which Li has been depleted by nuclear reactions, the lithium depletion boundary (LDB), has been advanced as an almost model-independent means of establishing an age scale for young stars. Here we construct polytropic models of contracting pre-main sequence stars (PMS) that have cool, magnetic starspots blocking a fraction $β$ of their photospheric flux. Starspots slow the descent along Hayashi tracks, leading to lower core temperatures and less Li destruction at a given mass and age. The age, $τ_{\rm LDB}$, determined from the luminosity of the LDB, $L_{\rm LDB}$, is increased by a factor $(1-β)^{-E}$ compared to that inferred from unspotted models, where $E \simeq 1 + d\log τ_{\rm LDB}/d \log L_{\rm LDB}$ and has a value $\sim 0.5$ at ages $< 80$ Myr, decreasing to $\sim 0.3$ for older stars. Spotted stars have virtually the same relationship between K-band bolometric correction and colour as unspotted stars, so this relationship applies equally to ages inferred from the absolute K magnitude of the LDB. Low-mass PMS stars do have starspots, but the appropriate value of $β$ is highly uncertain with a probable range of $0.1 < β< 0.4$. For the smaller $β$ values our result suggests a modest systematic increase in LDB ages that is comparable with the maximum levels of theoretical uncertainty previously claimed for the technique. The largest $β$ values would however increase LDB ages by 20-30 per cent and demand a re-evaluation of other age estimation techniques calibrated using LDB ages.
description: 10 pages, MNRAS in press
Variable and value elimination in binary constraint satisfaction via forbidden patterns
Creators: name: Cohen, David A.
name: Cooper, Martin C.
name: Escamocher, Guillaume
name: Zivny, Stanislav
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Complexity (cs.CC)
subject: Artificial Intelligence (cs.AI)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences
subject: F.2.0

description: Variable or value elimination in a constraint satisfaction problem (CSP) can be used in preprocessing or during search to reduce search space size. A variable elimination rule (value elimination rule) allows the polynomial-time identification of certain variables (domain elements) whose elimination, without the introduction of extra compensatory constraints, does not affect the satisfiability of an instance. We show that there are essentially just four variable elimination rules and three value elimination rules defined by forbidding generic sub-instances, known as irreducible existential patterns, in arc-consistent CSP instances. One of the variable elimination rules is the already-known Broken Triangle Property, whereas the other three are novel. The three value elimination rules can all be seen as strict generalisations of neighbourhood substitution.
description: A full version of an IJCAI'13 paper to appear in Journal of Computer and System Sciences (JCSS)
Formular für ein Deckblatt für Zweitveröffentlichungen
Creators: name: Kobusch, Alexander
Publisher: name: Zenodo
Year: 2022
Subjects: Open Access
Zweitveröffentlichung
Workflow
Bibliothek
Formular

description: Dieses PDF-Formular wird als Deckblatt für Zweitveröffentlichungen auf dem Publikationsserver der FH Bielefeld verwendet. Mit Hilfe des beigefügten Beipackzettels (PDF und Markdown), der die einzelnen Formularfelder und Funktionen beschreibt, kann die Datei auf die eigenen Bedürfnisse angepasst werden. Lizenzhinweis: Die Wort-Bild-Marke der FH Bielefeld ist von der CC0-Lizenz ausgenommen.
description: Der eigentliche Text des Deckblatts, der später im druckfertigen Deckblatt vorliegt, ist in englischer Sprache. Die Arbeitsanweisungen und Formularbeschreibungen sowie der Beipackzettel sind in deutscher Sprache.
Periacetabular Osteotomy and Postoperative Pregnancy—Is There an Influence on the Mode of Birth?
Creators: name: Schömig, Friederike
name: Hipfl, Christian
name: Löchel, Jannis
name: Perka, Carsten
name: Hardt, Sebastian
name: Leopold, Vincent Justus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: developmental hip dysplasia
subject: periacetabular osteotomy
subject: cesarean section
subject: pregnancy complications
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: As a surgical treatment option in symptomatic developmental dysplasia of the hip, periacetabular osteotomy (PAO) is often performed in female patients of childbearing age. Yet, to date, little is known about the procedure's influence on postoperative pregnancies and the mode of delivery. Our study's aim therefore was to investigate patient and physician decision making in women after PAO. We invited all patients who had undergone PAO in our institution from January 2015 to June 2017 to participate in a paper-based survey. Of these, we included all female patients and performed a retrospective chart review as well as analysis of pre- and postoperative radiological imaging. A total of 87 patients were included, 20 of whom gave birth to 26 children after PAO. The mean overall follow-up was 5.3 +/- 0.8 years. Four (20.0%) patients reported that their obstetrician was concerned due to their history of PAO. The mean time before the first child's birth was 2.9 +/- 1.3 years. Eleven (55.0%) patients underwent cesarean section for the first delivery after PAO, three of whom reported their history of PAO as the reason for this type of delivery. Patients with a history of PAO have a higher risk of delivering a child by cesarean section compared with the general population, in which the rate of cesarean section is reported to be 29.7%. As cesarean sections are associated with increased morbidity and mortality compared with vaginal deliveries, evidence-based recommendations for pregnancies after pelvic osteotomy are needed.
Building Trustworthy Repositories: Introduction to CoreTrustSeal Certification
Creators: name: Parkoła, Tomasz
name: Horik, René Van
name: Jerlehag, Birger
name: Broeder, Daan
Publisher: name: Zenodo
Year: 2020
Subjects: CoreTrustSeal
Social Sciences and Humanities Open Cloud
SSHOC project

description: Introductory presentation for the "Building Trustworthy Repositories: Introduction to CoreTrustSeal Certification" workshop. It gives an overview of the SSHOC project, especially in the context of task 8.2 which deals with trustworthy repositories.
Proceedings of the 16th International Conference on Automata and Formal Languages
Creators: name: Gazdag, Zsolt
name: Iván, Szabolcs
name: Kovásznai, Gergely
Publisher: name: arXiv
Year: 2023
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences

description: The 16th International Conference on Automata and Formal Languages (AFL 2023) was held in Eger, September 5-7, 2023. It was organized by the Eszterházy Károly Catholic University of Eger, Hungary, and the University of Szeged, Hungary. Topics of interest covered the theory and applications of automata and formal languages and related areas. This volume contains the texts of the 3 invited presentations and the 18 papers selected by the International Program Committee from a total of 23 submissions. We would like to thank everybody who submitted a paper to the conference.
The star formation activity in cosmic voids
Creators: name: Ricciardelli, Elena
name: Cava, Antonio
name: Varela, Jesus
name: Quilis, Vicent
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using a sample of cosmic voids identified in the Sloan Digital Sky Survey Data Release 7, we study the star formation activity of void galaxies. The properties of galaxies living in voids are compared with those of galaxies living in the void shells and with a control sample, representing the general galaxy population. Void galaxies appear to form stars more efficiently than shell galaxies and the control sample. This result can not be interpreted as a consequence of the bias towards low masses in underdense regions, as void galaxy subsamples with the same mass distribution as the control sample also show statistically different specific star formation rates. This highlights the fact that galaxy evolution in voids is slower with respect to the evolution of the general population. Nevertheless, when only the star forming galaxies are considered, we find that the star formation rate is insensitive to the environment, as the main sequence is remarkably constant in the three samples under consideration. This fact implies that environmental effects manifest themselves as fast quenching mechanisms, while leaving the non-quenched galaxies almost unaffected, as their star formation activity is largely regulated by the mass of their halo. We also analyse galaxy properties as a function of void-centric distance and find that the enhancement in the star formation activity with respect to the control sample is observable up to a radial distance 1.5 Rvoid. This result can be used as a suitable definition of void shells. Finally, we find that larger voids show an enhanced star formation activity in the shells with respect to their smaller counterparts, that could be related to the different dynamical evolution experienced by voids of different sizes.
description: 11 pages, 10 figures, 1 table. Accepted for publication in MNRAS
Die Familien mögen in den Gefahren des heutigen Fortschrittes durch die Glaubenslehre und durch häufigeren Sakramentsempfang gestärkt werden
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 15 Nr. 5 (1960): Herder Korrespondenz, Band 15, Heft 5
Detailed chemical composition of wide FGK+M binary systems
Creators: name: Duque-Arribas, C.
name: Tabernero, H. M.
name: Montes, D.
name: Caballero, J. A.
Publisher: name: Zenodo
Year: 2023
Subjects: Stars: abundances
Stars: fundamental parameters
Binaries: visual

description: Detailed chemical composition of stars is of prime interest for a range of topics in modern stellar astrophysics, such as the chemical evolution of the Galaxy or the formation, composition, and structure of exoplanets. In this work, we derive the C and O abundances and update Sc, V, Mn, and Co abundances considering HFS effects for the primary stars in FGK+M wide binary systems by means of the equivalent width (EW) method and high-resolution spectroscopic data, complementing the previous study of several elements (Fe, Mg, Si, Ca, Ti, Cr, Ni, Na, and Al). These individual abundances can be extrapolated to the secondary M dwarfs, whose spectra are complex and notoriously difficult to model due to the presence of prominent molecular features. Lastly, we provide abundance calibrationswhich allow us to estimate individual abundances for M dwarfs using spectral indices computed from low-resolution spectra. In conclusion, this work covers the study of chemical abundances in FGK stars and expands it to the M dwarfs, providing a new method to estimate their chemical composition.
description: {"references": ["Alonso-Floriano, F. J. et al. 2015, A&A, 577, A128", "Battistini, C. & Bensby, T. 2015, A&A, 577, A9", "Delgado Mena, E. et al. 2021, A&A, 655, A99", "Montes, D. et al 2018, MNRAS, 479, 1332"]}
Should we build more large dams? The actual costs of hydropower megaproject development
Creators: name: Ansar, Atif
name: Flyvbjerg, Bent
name: Budzier, Alexander
name: Lunn, Daniel
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: A brisk building boom of hydropower mega-dams is underway from China to Brazil. Whether benefits of new dams will outweigh costs remains unresolved despite contentious debates. We investigate this question with the "outside view" or "reference class forecasting" based on literature on decision-making under uncertainty in psychology. We find overwhelming evidence that budgets are systematically biased below actual costs of large hydropower dams - excluding inflation, substantial debt servicing, environmental, and social costs. Using the largest and most reliable reference data of its kind and multilevel statistical techniques applied to large dams for the first time, we were successful in fitting parsimonious models to predict cost and schedule overruns. The outside view suggests that in most countries large hydropower dams will be too costly in absolute terms and take too long to build to deliver a positive risk-adjusted return unless suitable risk management measures outlined in this paper can be affordably provided. Policymakers, particularly in developing countries, are advised to prefer agile energy alternatives that can be built over shorter time horizons to energy megaprojects.
title: Impact de la pollution sonore urbaine sur la santé de la population
title: Impact de la pollution sonore urbaine sur la santé de la population
titleType: AlternativeTitle
Creators: name: Forestier, Léandrine Alicia
name: Niclass, Oriana
Publisher: name: Unknown
Year: 0
Subjects: subject: Santé environnementale
subject: Pollution sonore
subject: Santé communautaire

description: Le domaine de la santé environnementale est un sujet d’actualité qui semble pertinent à traiter en raison de l’urbanisation grandissante. La pollution sonore est une nuisance qui parait anodine mais qui a en réalité de multiples conséquences sur la santé. Le but de ce travail est de répondre à la problématique suivante : Quelles interventions infirmières de prévention pouvons-nous développer auprès des personnes particulièrement exposées à la pollution sonore ? L'objectif est, dans un premier temps, de comprendre comment la pollution sonore en milieu urbain affecte notre santé, pour ensuite, trouver des interventions que les infirmier-ères pourraient mettre en place dans leur pratique professionnelle.
Co-spatial Long-slit UV/Optical Spectra of Ten Galactic Planetary Nebulae with HST/STIS I. Description of the Observations, Global Emission-line Measurements, and CNO Abundances
Creators: name: Dufour, Reginald J.
name: Kwitter, Karen B.
name: Shaw, Richard A.
name: Henry, Richard B. C.
name: Balick, Bruce
name: Corradi, Romano L. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present observations and initial analysis from an HST/STIS program to obtain the first co-spatial, UV-optical spectra of ten Galactic planetary nebulae (PNe). Our primary objective was to measure the critical emission lines of carbon and nitrogen with unprecedented S/N and spatial resolution over UV-optical range, with the ultimate goal of quantifying the production of these elements in low- and intermediate-mass stars. Our sample was selected from PNe with a near-solar metallicity, but spanning a broad range in N/O. This study, the first of a series, concentrates on the observations and emission-line measurements obtained by integrating along the entire spatial extent of the slit. We derived ionic and total elemental abundances for the seven PNe with the strongest UV line detections (IC~2165, IC~3568, NGC~2440, NGC~3242, NGC~5315, NGC~5882, and NGC~7662). We compare these new results with other recent studies of the nebulae, and discuss the relative merits of deriving the total elemental abundances of C, N, and O using ionization correction factors (ICFs) versus summed abundances. For the seven PNe with the best UV line detections, we conclude that summed abundances from direct diagnostics of ions with measurable UV lines gives the most accurate values for the total elemental abundances of C and N. In some cases where significant discrepancies exist between our abundances and those from other studies, we show that the differences can often be attributed to their use of fluxes that are not co-spatial. Finally, we examined C/O and N/O versus O/H and He/H in well-observed Galactic, LMC, and SMC PNe, and found that highly accurate abundances are essential for properly inferring elemental yields from their progenitor stars.
description: 46 pages, 7 figures, 9 tables; to be published in the Astrophysical Journal
A Survey of Irradiated Pillars, Globules, and Jets in the Carina Nebul
Creators: name: Hartigan, P.
name: Reiter, M.
name: Smith, N.
name: Bally, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present wide-field, deep narrowband H$_2$, Br$γ$, H$α$, [S II], [O III], and broadband I and K-band images of the Carina star formation region. The new images provide a large-scale overview of all the H$_2$ and Br$γ$ emission present in over a square degree centered on this signature star forming complex. By comparing these images with archival HST and Spitzer images we observe how intense UV radiation from O and B stars affects star formation in molecular clouds. We use the images to locate new candidate outflows and identify the principal shock waves and irradiated interfaces within dozens of distinct areas of star-forming activity. Shocked molecular gas in jets traces the parts of the flow that are most shielded from the intense UV radiation. Combining the H$_2$ and optical images gives a more complete view of the jets, which are sometimes only visible in H$_2$. The Carina region hosts several compact young clusters, and the gas within these clusters is affected by radiation from both the cluster stars and the massive stars nearby. The Carina Nebula is ideal for studying the physics of young H II regions and PDR's, as it contains multiple examples of walls and irradiated pillars at various stages of development. Some of the pillars have detached from their host molecular clouds to form proplyds. Fluorescent H$_2$ outlines the interfaces between the ionized and molecular gas, and after removing continuum, we detect spatial offsets between the Br$γ$ and H$_2$ emission along the irradiated interfaces. These spatial offsets can be used to test current models of PDRs once synthetic maps of these lines become available.
description: Accepted in the Astronomical Journal
OʻZBEKISTONDA TURIZM INFRATUZILMASI VA UNING TASNIFI
Creators: name: Ismoilova, Farangiz
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada Oʻzbekistonda turizm infratuzilmasining holati, uning rivojlanish yoʻnalishlari va turistik xizmatlar tizimidagi ahamiyati tahlil qilinadi. Turizm infratuzilmasi turli elementlar – transport, mehmonxona, ko'ngilochar va axborot texnologiyalari infratuzilmasi – bilan chambarchas bog'liqdir. Maqolada shuningdek, ekologik turizm infratuzilmasi va uning Oʻzbekiston turizmidagi oʻrni ham koʻrib chiqiladi. Turizm infratuzilmasining rivojlanishi mamlakatning xalqaro turizm maydonida raqobatbardoshligini oshirishga va iqtisodiyotning o'sishiga xizmat qiluvchi omil sifatida baholanadi.
The impact of COVID-19 and associated shocks on agri-food SMEs along the poultry and fish value chains in Abuja (FCT), Nigeria
Creators: name: Muhammad, Aisha
name: Tasie, Saweda
name: Belton, Ben
name: Tasie, Oyinkan
name: Reardon, Thomas
name: Wellington, Osawe
name: Muhammad, Aisha
name: Tasie, Saweda
name: Belton, Ben
name: Tasie, Oyinkan
name: Reardon, Thomas
name: Wellington, Osawe
Publisher: name: Unknown
Year: 2021
Subjects: subject: Agricultural and Food Policy
subject: Policy
subject: Economics
subject: Agriculture
subject: Covid
subject: Nigeria

description: This policy research note summarizes the key findings from a study on the impact of COVID-19 and associated policies on SMEs along the poultry and fish value chains in Abuja (FCT).
Verification of a Novel Minimally Invasive Device for the Isolation of Rare Circulating Tumor Cells (CTC) in Cancer Patients’ Blood
Creators: name: Geus, Paul Friedrich
name: Hehnen, Felix
name: Krakowski, Sophia
name: Lücke, Klaus
name: Hoon, Dave S. B.
name: Frost, Nikolaj
name: Kertzscher, Ulrich
name: Wendt, Gabi
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: circulating tumor cells (CTCs)
subject: minimally invasive
subject: liquid biopsy
subject: non-small-cell lung carcinoma
subject: cancer diagnosis
subject: medical device
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Simple Summary: Detection of circulating tumor cells (CTCs) in blood can be used to diagnose cancer or monitor treatment response for various cancers. However, these cells are rare in the bloodstream in the early stages of cancers, and it, therefore, remains a technical challenge to isolate them. To overcome the limitations of a blood draw, we introduce a minimally invasive device, called the BMProbe (TM), for the isolation of CTCs directly from the bloodstream. Thereby a large volume of blood is screened. This study first shows how the geometry of the in vivo BMProbe (TM) causes improved cell deposition conditions. We then performed a verification of the in vivo device using blood samples from lung cancer patients. The results indicate the functionality of the BMProbe (TM) to isolate CTCs in blood samples. The future step is to use the BMProbe (TM) in various types of cancer patients to detect CTCs. Abstract: Circulating tumor cells (CTCs) exist in low quantities in the bloodstream in the early stages of cancers. It, therefore, remains a technical challenge to isolate them in large enough quantities for a precise diagnosis and downstream analysis. We introduce the BMProbe (TM), a minimally invasive device that isolates CTCs during a 30-minute incubation in the median cubital vein. The optimized geometry of the device creates flow conditions for improved cell deposition. The CTCs are isolated using antibodies that are bound to the surface of the BMProbe (TM). In this study, flow experiments using cell culture cells were conducted. They indicate a 31 times greater cell binding efficiency of the BMProbe (TM) compared to a flat geometry. Further, the functionality of isolating CTCs from patient blood was verified in a small ex vivo study that compared the cell count from seven non-small-cell lung carcinoma (NSCLC) patients compared to nine healthy controls with 10 mL blood samples. The median cell count was 1 in NSCLC patients and 0 in healthy controls. In conclusion, the BMProbe (TM) is a promising method to isolate CTCs in large quantities directly from the venous bloodstream without removing blood from a patient. The future step is to verify the functionality in vivo.
What You Should Know About Megaprojects, and Why: An Overview
Creators: name: Flyvbjerg, Bent
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: This paper takes stock of megaproject management, an emerging and hugely costly field of study. First, it answers the question of how large megaprojects are by measuring them in the units mega, giga, and tera, concluding we are presently entering a new "tera era" of trillion-dollar projects. Second, total global megaproject spending is assessed, at USD 6-9 trillion annually, or 8 percent of total global GDP, which denotes the biggest investment boom in human history. Third, four "sublimes" - political, technological, economic, and aesthetic - are identified to explain the increased size and frequency of megaprojects. Fourth, the "iron law of megaprojects" is laid out and documented: Over budget, over time, over and over again. Moreover, the "break-fix model" of megaproject management is introduced as an explanation of the iron law. Fifth, Albert O. Hirschman's theory of the Hiding Hand is revisited and critiqued as unfounded and corrupting for megaproject thinking in both the academy and policy. Sixth, it is shown how megaprojects are systematically subject to "survival of the unfittest," explaining why the worst projects get built instead of the best. Finally, it is argued that the conventional way of managing megaprojects has reached a "tension point," where tradition is challenged and reform is emerging.
An Iterative Approach for Collision Feee Routing and Scheduling in Multirobot Stations
Creators: name: Spensieri, Domenico
name: Carlson, Johan S.
name: Ekstedt, Fredrik
name: Bohlin, Robert
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This work is inspired by the problem of planning sequences of operations, as welding, in car manufacturing stations where multiple industrial robots cooperate. The goal is to minimize the station cycle time, \emph{i.e.} the time it takes for the last robot to finish its cycle. This is done by dispatching the tasks among the robots, and by routing and scheduling the robots in a collision-free way, such that they perform all predefined tasks. We propose an iterative and decoupled approach in order to cope with the high complexity of the problem. First, collisions among robots are neglected, leading to a min-max Multiple Generalized Traveling Salesman Problem (MGTSP). Then, when the sets of robot loads have been obtained and fixed, we sequence and schedule their tasks, with the aim to avoid conflicts. The first problem (min-max MGTSP) is solved by an exact branch and bound method, where different lower bounds are presented by combining the solutions of a min-max set partitioning problem and of a Generalized Traveling Salesman Problem (GTSP). The second problem is approached by assuming that robots move synchronously: a novel transformation of this synchronous problem into a GTSP is presented. Eventually, in order to provide complete robot solutions, we include path planning functionalities, allowing the robots to avoid collisions with the static environment and among themselves. These steps are iterated until a satisfying solution is obtained. Experimental results are shown for both problems and for their combination. We even show the results of the iterative method, applied to an industrial test case adapted from a stud welding station in a car manufacturing line.