cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
К ВОПРОСУ О ПРОБЛЕМАХ КВАЛИФИКАЦИИ ТАМОЖЕННЫХ ПРЕСТУПЛЕНИЙ, В ТОМ ЧИСЛЕ, СОВЕРШЕННЫХ ПОСРЕДСТВОМ ПОЧТОВЫХ ОТПРАВЛЕНИЙ
Creators: name: П. А. Антось
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: таможенный контроль
контрабанда
таможенное регулирование
проблемы квалификации
Постановление Пленума ВС РФ
уголовный закон
ТК ЕАЭС
УК РФ
КоАП РФ.

description: В настоящей работе рассматриваются актуальные вопросы, касающиеся проблем квалификации преступлений, совершенных в сфере таможенных правоотношений. Дается правовая оценка деятельности органов таможенного контроля по вопросам отграничения составов таможенных нарушений от преступлений, предусмотренных уголовным законом. Анализируются положения Постановления Пленума Верховного Суда РФ по вопросам, касающимся таможенных преступлений, совершенных, в том числе, посредством почтовых отправлений
TBCRC 002: A phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancer
Creators: name: Myers, R.M.
name: Carey, L.A.
name: Vaklavas, C.
name: Delossantos, J.F.
name: Roberts, B.S.
name: Storniolo, A.M.
name: Forero-Torres, A.
name: Saleh, M.N.
name: Grizzle, W.E.
name: Varley, K.E.
name: Puhalla, S.
name: Rugo, H.S.
name: Nanda, R.
name: Lin, N.U.
name: Li, Y.
name: Lobuglio, A.F.
name: Liu, M.C.
Publisher: name: BioMed Central Ltd.
Year: 2020

description: Background: In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with estrogen-independent tumor growth and resistance to endocrine therapies. This study investigated whether the addition of bevacizumab, a monoclonal antibody against VEGF, to letrozole enhanced the antitumor activity of the letrozole in the preoperative setting. Methods: Postmenopausal women with newly diagnosed stage 2 or 3 estrogen and/or progesterone receptor-positive, HER2-negative breast cancer were randomly assigned (2:1) between letrozole 2.5 mg PO daily plus bevacizumab 15 mg/kg IV every 3 weeks (Let/Bev) and letrozole 2.5 mg PO daily (Let) for 24 weeks prior to definitive surgery. Primary objective was within-arm pathologic complete remission (pCR) rate. Secondary objectives were safety, objective response, and downstaging rate. Results: Seventy-five patients were randomized (Let/Bev n = 50, Let n = 25). Of the 45 patients evaluable for pathological response in the Let/Bev arm, 5 (11%; 95% CI, 3.7-24.1%) achieved pCR and 4 (9%; 95% CI, 2.5-21.2%) had microscopic residual disease; no pCRs or microscopic residual disease was seen in the Let arm (0%; 95% CI, 0-14.2%). The rates of downstaging were 44.4% (95% CI, 29.6-60.0%) and 37.5% (95% CI, 18.8-59.4%) in the Let/Bev and Let arms, respectively. Adverse events typically associated with letrozole (hot flashes, arthralgias, fatigue, myalgias) occurred in similar frequencies in the two arms. Hypertension, headache, and proteinuria were seen exclusively in the Let/Bev arm. The rates of grade 3 and 4 adverse events and discontinuation due to adverse events were 18% vs 8% and 16% vs none in the Let/Bev and Let arms, respectively. A small RNA-based classifier predictive of response to preoperative Let/Bev was developed and confirmed on an independent cohort. Conclusion: In the preoperative setting, the addition of bevacizumab to letrozole was associated with a pCR rate of 11%; no pCR was seen with letrozole alone. There was additive toxicity with the incorporation of bevacizumab. Responses to Let/Bev can be predicted from the levels of 5 small RNAs in a pretreatment biopsy. Trial registration: This trial is registered with ClinicalTrials.gov (Identifier: NCT00161291), first posted on September 12, 2005, and is completed.
МАРКИРОВКА АЛКОГОЛЬНОЙ ПРОДУКЦИИ КАК СРЕДСТВО ЕЕ ИДЕНТИФИКАЦИИ ТАМОЖЕННЫМИ ОРГАНАМИ
Creators: name: Р. Р. Ахмедзянов
name: Д. А. Коротков
name: В. С. Карепанов
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: таможенный контроль
идентификация
маркировка
специальные марки
штрихкод

description: Создание системы маркировки специальными марками продукции дает возможность таможенным органам получения оперативной и достоверной информации о ее движении. Это дает возможность осуществления контроля за незаконным оборотом алкогольной продукции и предотвращения его на внутренний рынок страны. Маркировка продукции является средством идентификации, которое применяется в порядке, установленном Правительством Российской Федерации. В статье рассматриваются особенности идентификации каждой единицы алкогольной продукции путем маркировки специальными марками имеющими штрихкод
ПРОБЛЕМЫ ОРГАНИЗАЦИИ НАУЧНОГО ОБЕСПЕЧЕНИЯ ПРАВООХРАНИТЕЛЬНОЙ ДЕЯТЕЛЬНОСТИ ОРГАНОВ ВНУТРЕННИХ ДЕЛ РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: А. А. Бадин
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: научное обеспечение
положительный опыт
полиция
органы внутренних дел.

description: Впервые закрепленный в отечественной нормотворческой практике Федеральным законом от 07.02.2011 № 3-ФЗ «О полиции» [1] принцип использования достижений науки и техники, современных технологий и информационных систем обусловливает интерес к вопросам научного обеспечения деятельности органов внутренних дел Российской Федерации (далее – ОВД). Указанная новелла фактически придала императивный характер наметившейся в последние годы тенденции внедрения в правоохранительную деятельность новейших научно-технических разработок в области выявления, раскрытия и расследования преступлений, обеспечения общественного порядка, «цифровизации» государственных услуг, оказываемых МВД России (далее также – Министерство), широкого использования баз данных и автоматизированных систем обработки информации. Вместе c тем реализация этого принципа на практике требует надлежащей организации научного обеспечения деятельности ОВД, начиная, прежде всего, с определения соответствующего понятийного аппарата, устранения пробелов и коллизий в правовом регулировании. Цель настоящего исследования заключается в анализе правовых актов, регламентирующих организацию научного обеспечения правоохранительной деятельности ОВД, а также соответствующего понятийного аппарата. На его основе иллюстрируются пробелы и коллизии в правовом регулировании указанной сферы, обусловливающие необходимость комплексной переработки системы ведомственных нормативных правовых актов в этой области.
ПРОБЛЕМЫ БОРЬБЫ С НЕЗАКОННЫМ ОБОРОТОМ КОНТРАФАКТНОЙ ПРОДУКЦИИ
Creators: name: Е. А. Ботарева
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: контрафактная продукция
ЕАЭС
Международный формум «Антиконтрафакт»
товарный фирменный знак
исключительные права собственности

description: В данной статье рассматриваются проблемы борьбы с контрафактной продукцией. Борьба с контрафактной продукцией – одна из наиболее важных проблем в сфере защиты прав интеллектуальной собственности. Оборот контрафактной продукции наносит ущерб экономике страны и подрывает доверие к производителю. В рамках выполненного исследования, автор приходит к выводу, что усилением борьбы с оборотом контрафактной продукции является установление правовых и экономических основ поддержки добросовестных товаропроизводителей.
ЮРИДИЧЕСКАЯ ОТВЕТСТВЕННОСТЬ ФИЗИЧЕСКИХ ЛИЦ ЗА НЕСОБЛЮДЕНИЕ ЗАПРЕТОВ И ОГРАНИЧЕНИЙ ПРИ ПЕРЕМЕЩЕНИИ ТОВАРОВ ЧЕРЕЗ ТАМОЖЕННУЮ ГРАНИЦУ ЕАЭС
Creators: name: О. С. Дровнина
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: юридическая ответственность
физическое лицо
ограничения
экономическая безопасность
Евразийский экономический союз

description: Соблюдение запретов и ограничений физическими лицами при перемещении через таможенную границу евразийского Экономического Союза важная составляющая внешнеторговой деятельности. В данной статье рассматриваются основные виды нарушений и ответственность физических лиц за не соблюдение данных запретов и ограничений. А также описаны точные требования, соблюдение которых обеспечит законное перемещение товаров и транспортных средств через границу Союза
ПРОБЛЕМЫ КВАЛИФИКАЦИИ УКЛОНЕНИЯ ОТ УПЛАТЫ НАЛОГОВ И СТРАХОВЫХ ВЗНОСОВ
Creators: name: Ю. Илларионова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: налоги
страховые взносы
уклонение от уплаты
уголовная ответственность
квалификация преступления.

description: В статье автор характеризует налоговые преступления, освещает пробелы в законодательстве. Достаточно актуальна проблема терминов в уголовном законодательстве, которую автор предлагает устранить. Также исследуются спорные вопросы квалификации преступлений, связанных с уклонением от уплаты налогов и страховых сборов, отмечаются проблемы, существующие в правоприменительной практике в отношении полноты квалификации указанных преступлений, при определении признаков конкретного преступления и мер ответственности
Cultural Competence and Caring Behavior Among Inpatient Staff Nurses in Al Wakra Hospital, Qatar
Creators: name: Moratillo, Mary Grace P.
Publisher: name: Zenodo
Year: 2021
Subjects: subject: Cultural Anthropology
subject: Nursing
subject: FOS: Health sciences

description: Providing culturally competent and high-quality nursing care is a nurse's professional and moral responsibility and is one of the essential nursing attributes. Qatar has multicultural residents and a healthcare workforce. This highly multicultural society poses a challenge to modern healthcare to meet multicultural patient needs. However, a study correlating nurses' cultural competence and caring behavior lacks the current setting and literature that could help address this challenge. This descriptive correlational study understands the relationship between nurses' cultural competence and caring behavior. It also examines the influence of socio-demographic characteristics on nurses' cultural competence and caring behavior. A total of 239 nurses, recruited via stratified random sampling, participated among the adult inpatient nurses of Al Wakra Hospital in Al Wakra, Qatar. Cultural Capacity Scale (CCS) and Caring Behavior Inventory-24 (CBI-24) were used to collect the data. Data were analyzed using IBM SPSS Statistics 20.0 software. Majority of the nurses were from the 30 to 39 age group, Filipino, Christians, had a bachelor’s degree, and 6 – 10 years of nursing experience. Female nurses outnumbered the male nurses assigned in the Medical and Surgical Inpatient and Critical Care Unit. The result indicated a significant relationship but weak correlation between nurses' cultural competence and caring behavior (rs = 0.207, p=0.001). This finding suggests the higher the level of cultural competence, the higher the nurses' quality of caring attitude. It also revealed no salient relationship between the nurses' socio-demographic characteristics and cultural competency and caring attributes (p>0.05). The healthcare facility is recommended to establish cultural competency program/s to equip the nurses further in providing culturally sensitive and high-quality care.
МЕТОДОЛОГИЧЕСКИЕ ПОДХОДЫ К ИССЛЕДОВАНИЮ ПРАВОВЫХ ЦЕННОСТЕЙ
Creators: name: Е. М. Ковальчук
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: ценность
право
право как ценность
правовые ценности
методология.

description: Проанализированы методологические основы исследования правовых ценностей. Использование различных концептуальных подходов и методов позволило исследовать правовые ценности всесторонне и комплексно. Сделан акцент на актуализации разработки специальной методологии, которая определяет концептуальные подходы, методы и другие инструменты их познания. Подчеркнуто, что наиболее полно специфику правовых ценностей раскрывают возможности аксиологической методологии.
GREAT D5.1 Evaluation Framework
Creators: name: Koller, Katharina
name: Kieslinger, Barbara
name: Fabian, Claudia
Publisher: name: Zenodo
Year: 2024
Subjects: Game-based methods
Political engagement
Social engagement
Climate crisis
Policy issues
Citizens and policymakers
Evaluation framework
Public engagement
Citizen science
Gamification
Impact assessment
Logic model
Scientific dimension
Individual actors' dimension
Economic dimension
Societal dimension
Indicators
Data collection
Qualitatice measures
Quantitative measures
Outcomes
Modular approach
Participatory processes
Formative evaluation
Drivers for engagement
Games for climate change
Evaluation instruments
Citizen science research
GREAT Project

description: The overall objective of GREAT is using game-based methods for the political and social engagement of citizens regarding the climate crisis, aiming to address current policy issues and closing the gap between citizens and policymakers. This document provides the basis for the evaluation and impact assessment performed during the course of the project. It discusses theoretical concepts that have been combined to define an evaluation framework specifically designed for GREAT. The framework builds on public engagement and participation concepts, such as Citizen Science, next to gamified approaches, all with a special view on Climate Change as the core topic of concern in GREAT. We focus our impact assessment on four dimensions following a logic model approach and for each of these dimensions we define a set of indicators and methods on data gathering: - Scientific dimension - Individual actors’ dimension - Economic dimension - Societal dimension The logic models for each of these dimensions allows us to present logical relationships between the project’s inputs, activities, outputs, outcomes, and impacts. For defining appropriate indicators for each of the dimension we relate them back to the theoretical concepts that we discuss in this document and match them with the two distinct game-based interventions (DIBL and Playmob). The data collection instruments that we plan to apply across the GREAT case studies include qualitative and quantitative measures, such as interviews and questionnaires. Within the constraints of the project time frame, we will most probably only be able to collect data at output and outcomes level. However, we will also try to identify indications of possible impact, which holds a long-term perspective. The evaluation and impact assessment approach presented in this document offers a comprehensive and modular approach, which will be tailored to the specific case studies in the course of the GREAT project.
ЖЕРТВА КРИМИНАЛЬНОГО КОРРУПЦИОННОГО ПОВЕДЕНИЯ
Creators: name: Н. С. Кожевникова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: жертва
преступление
коррупционное поведение
криминальная коррупция
коррупционное преступление

description: Коррупция является значимой угрозой интересам юридических и физических лиц. Статья посвящена анализу классификации жертв криминального коррупционного поведения. Исследован круг лиц, которых можно отнести к жертвам коррупционного криминального поведения, рассмотрены их признаки. Приведены аргументы исключения из числа жертв криминального коррупционного поведения государства, общества и широкого круга социальных институтов. Сформулирована дефиниция жертвы криминального коррупционного поведения.
Weight trajectories in women receiving systemic adjuvant therapy for breast cancer
Creators: name: Shachar, S.S.
name: Nyrop, K.A.
name: Deal, A.M.
name: Wheless, A.
name: Choi, S.K.
name: Lee, J.T.
name: O'Hare, E.A.
name: Muss, H.B.
name: Carey, L.A.
name: Park, J.
Publisher: name: Springer
Year: 2020

description: Background: Weight gain after breast cancer (BC) diagnosis is a well-known phenomenon; however, it is not a universal phenomenon and identification of patients at highest risk for weight gain is needed. This study investigates weight trajectories in early BC patients at 2 years post-primary treatment, examining potential contributing factors such as age, race, and receipt of chemotherapy, anti-HER-2 therapy, and endocrine treatment (ET). Methods: A single institution cohort of newly diagnosed women age 21 and older with early breast cancer patients (Stage 0–3) were identified by retrospective chart review (diagnosis year 1995 to 2016). Log-binomial regression models for net weight changes at 2 years post-primary treatment including patient demographic, clinical, and treatment characteristics. Results: The final sample of 625 patients included 29% who were non-White and 37% who were pre-menopausal at diagnosis. Body mass index (BMI) at diagnosis was calculated and found to be normal in 33% (BMI 18 to < 25), overweight in 27% (BMI 25 to < 30), and obese in 40% (BMI 30 and higher). At 2 years, compared to weight at diagnosis, 31% had lost > 2 kg, 34% had stable weight ± 2 kg, and 35% had gained > 2 kg. Factors associated with > 2 kg weight gain were menopausal status (pre-menopausal HR 1.65, 95% CI 1.34–2.04, p <.0001), receiving any chemotherapy (HR 1.36, 95% CI 1.04–1.77), and anthracycline-based chemotherapy followed by ET (HR 1.60, CI 1.01–2.45). Anti-HER-2 therapy and transition from pre- to post-menopausal during the 2-year study period were not significant factors in weight gain. In multivariate analysis, menopausal status remained the only significant variable related to weight gain when adjusted for treatment. For all treatment combinations, pre-menopausal women had significantly more weight gain. Conclusions and relevance: Weight gain, weight loss, and stable weight in women with early breast cancer vary greatly by treatment plan. However, pre-menopausal patients have the highest risk for weight gain.
Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications
Creators: name: Garcia-Recio, S.
name: Olshan, A.F.
name: Anderson, W.F.
name: Sun, X.
name: Troester, M.A.
name: Chen, M.
name: Pfeiffer, R.M.
name: Kirk, E.L.
name: Shan, Y.
name: Geradts, J.
name: Allott, E.H.
name: Perou, C.M.
name: Earp, H.S.
name: Carey, L.A.
Publisher: name: Springer
Year: 2020

description: Purpose: Female breast cancer demonstrates bimodal age frequency distribution patterns at diagnosis, interpretable as two main etiologic subtypes or groupings of tumors with shared risk factors. While RNA-based methods including PAM50 have identified well-established clinical subtypes, age distribution patterns at diagnosis as a proxy for etiologic subtype are not established for molecular and genomic tumor classifications. Methods: We evaluated smoothed age frequency distributions at diagnosis for Carolina Breast Cancer Study cases within immunohistochemistry-based and RNA-based expression categories. Akaike information criterion (AIC) values compared the fit of single density versus two-component mixture models. Two-component mixture models estimated the proportion of early-onset and late-onset categories by immunohistochemistry-based ER (n = 2860), and by RNA-based ESR1 and PAM50 subtype (n = 1965). PAM50 findings were validated using pooled publicly available data (n = 8103). Results: Breast cancers were best characterized by bimodal age distribution at diagnosis with incidence peaks near 45 and 65 years, regardless of molecular characteristics. However, proportional composition of early-onset and late-onset age distributions varied by molecular and genomic characteristics. Higher ER-protein and ESR1-RNA categories showed a greater proportion of late age-at-onset. Similarly, PAM50 subtypes showed a shifting age-at-onset distribution, with most pronounced early-onset and late-onset peaks found in Basal-like and Luminal A, respectively. Conclusions: Bimodal age distribution at diagnosis was detected in the Carolina Breast Cancer Study, similar to national cancer registry data. Our data support two fundamental age-defined etiologic breast cancer subtypes that persist across molecular and genomic characteristics. Better criteria to distinguish etiologic subtypes could improve understanding of breast cancer etiology and contribute to prevention efforts.
Cat-scratch Disease: Human Health Concern
Creators: name: V.C. Ingle, Alka Galav, Kritika Dhial and Navin Mishra
Publisher: name: The Scientific Frontiers
Year: 2025
Subjects: Health and wellness, scratch fever, feline, deep bites, cat

description: Cat bites are increasingly reported in India, posing a significant public health concern. Cats (Felis catus), considered relatives of tigers, can transmit various zoonotic diseases, including Cat-Scratch Disease (CSD), rabies, and tetanus. CSD, caused by Bartonella henselae, is spread through cat bites, scratches, or flea vectors, leading to flu-like symptoms, lymph node swelling, and, in severe cases, systemic complications. Rabies, a fatal viral disease, can also be transmitted through cat bites, necessitating prompt post-exposure prophylaxis. Additionally, Clostridium tetani introduced through deep bites can result in tetanus, leading to muscle stiffness and neurological issues. Cats may bite due to territorial behavior, fear, pain, or irritation from medical conditions like hyperthyroidism or arthritis. Preventive measures include proper flea control, sterilization, secure housing, and timely vaccination. Understanding cat behavior, ensuring proper handling, and educating pet owners can reduce bite incidents. Immediate wound care with soap and water, along with medical intervention, including post-bite rabies and tetanus vaccination, is crucial to preventing complications. Increasing public awareness can help mitigate the risks associated with cat bites.
HER2-enriched subtype and pathological complete response in HER2-positive breast cancer: A systematic review and meta-analysis
Creators: name: Schiff, R.
name: Guarneri, V.
name: Perou, C.M.
name: Conte, P.F.
name: Osborne, C.K.
name: Chic, N.
name: Prat, A.
name: Schettini, F.
name: Fernández-Martinez, A.
name: Veeraraghavan, J.
name: Rognoni, C.
name: Villagrasa, P.
name: Vidal, M.
name: Carey, L.A.
name: Pascual, T.
name: Brase, J.C.
name: Gonzalez-Farre, B.
name: Galván, P.
name: De Placido, S.
name: Locci, M.
name: Rimawi, M.F.
name: Conte, B.
name: Muñoz, M.
name: Adamo, B.
name: Griguolo, G.
name: Pernas, S.
name: Martínez, O.
name: Brasó-Maristany, F.
Publisher: name: W.B. Saunders Ltd
Year: 2020

description: Background: HER2-positive (HER2+) breast cancer (BC) comprises all the four PAM50 molecular subtypes. Among these, the HER2-Enriched (HER2-E) appear to be associated with higher pathological complete response (pCR) rates following anti-HER2-based regimens. Here, we present a meta-analysis to validate the association of the HER2-E subtype with pCR following anti-HER2-based neoadjuvant treatments with or without chemotherapy (CT). Methods: A systematic literature search was performed in February 2019. The primary objective was to compare the association between HER2-E subtype (versus others) and pCR. Selected secondary objectives were to compare the association between 1) HER2-E subtype and pCR in CT-free studies, 2) HER2-E subtype within hormone receptor (HR)-negative and HR+ disease and 3) HR-negative disease (versus HR+) and pCR in all patients and within HER2-E subtype. A random-effect model was applied. The Higgins’ I2 was used to quantify heterogeneity. Results: Sixteen studies were included, 5 of which tested CT-free regimens. HER2-E subtype was significantly associated with pCR in all patients (odds ratio [OR] = 3.50, p < 0.001, I2 = 33%), in HR+ (OR = 3.61, p < 0.001, I2 = 1%) and HR-negative tumors (OR = 2.28, p = 0.01, I2 = 47%). In CT-free studies, HER2-E subtype was associated with pCR in all patients (OR = 5.52, p < 0.001, I2 = 0%) and in HR + disease (OR = 4.08, p = 0.001, I2 = 0%). HR-negative status was significantly associated with pCR compared to HR + status in all patients (OR = 2.41, p < 0.001, I2 = 30%) and within the HER2-E subtype (OR = 1.76, p < 0.001, I2 = 0%). Conclusions: The HER2-E biomarker identifies patients with a higher likelihood of achieving a pCR following neoadjuvant anti-HER2-based therapy beyond HR status and CT use. Future trial designs to escalate or de-escalate systemic therapy in HER2+ disease should consider this genomic biomarker.
Post-stroke lateropulsion and rehabilitation outcomes: a retrospective analysis
Creators: name: Nolan, Jessica
name: Godecke, Erin
name: Spilsbury, Katrina
name: Singer, Barbara
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A person with post-stroke lateropulsion actively pushes themselves toward their hemiplegic side, or resists moving onto their non-hemiplegic side. This study aimed to determine the association of lateropulsion severity with: • Change in function (Functional Independence Measure – FIM) and lateropulsion severity (Four-Point Pusher Score – 4PPS) during inpatient rehabilitation; • Inpatient rehabilitation length of stay (LOS); • Discharge destination from inpatient rehabilitation. Retrospective data for 1,087 participants (aged ≥65 years) admitted to a stroke rehabilitation unit (2005–2018) were analysed using multivariable regression models. Complete resolution of lateropulsion was seen in 69.4% of those with mild lateropulsion on admission (n = 160), 49.3% of those with moderate lateropulsion (n = 142), and 18.8% of those with severe lateropulsion (n = 181). Average FIM change was lower in those with severe lateropulsion on admission than those with no lateropulsion (p < 0.001). Higher admission 4PPS was associated with reduced FIM efficiency (p < 0.001), longer LOS (p < 0.001), (adjusted mean LOS: 35.6 days for those with severe lateropulsion versus 27.0 days for those without), and reduced likelihood of discharge home (p < 0.001). Post-stroke lateropulsion is associated with reduced functional improvement and likelihood of discharge home. However, given a longer rehabilitation duration, most stroke survivors with moderate to severe lateropulsion can achieve important functional improvement.Implications for RehabilitationWhile people with post-stroke lateropulsion can be difficult to treat and require more resources than those without lateropulsion, the majority of those affected, even in severe cases, can make meaningful recovery with appropriate rehabilitation.Although those with moderate to severe post-stroke lateropulsion may have poorer outcomes (longer LOS and reduced likelihood of discharge home) it is still important to advocate for access to rehabilitation for this patient group to give them the opportunity for optimal functional recovery. While people with post-stroke lateropulsion can be difficult to treat and require more resources than those without lateropulsion, the majority of those affected, even in severe cases, can make meaningful recovery with appropriate rehabilitation. Although those with moderate to severe post-stroke lateropulsion may have poorer outcomes (longer LOS and reduced likelihood of discharge home) it is still important to advocate for access to rehabilitation for this patient group to give them the opportunity for optimal functional recovery.
Clinical Significance of Circulating Tumor Cells in Hormone Receptor–positive Metastatic Breast Cancer Patients who Received Letrozole with or without Bevacizumab
Creators: name: Asmus, E.J.
name: Partridge, A.
name: Rugo, H.S.
name: Scott, J.H.
name: Park, J.W.
name: Dickler, M.
name: Winer, E.P.
name: Magbanua, M.J.M.
name: Carey, L.A.
name: Ballman, K.V.
name: Savenkov, O.
Publisher: name: American Association for Cancer Research Inc.
Year: 2020

description: Purpose: We evaluated the prognostic and predictive value of circulating tumor cells (CTCs) hormone receptor–positive (HRþ) metastatic breast cancer (MBC) patients randomized to letrozole alone or letrozole plus bevacizumab in the first-line setting (CALGB 40503). Experimental Design: Blood samples were collected at pretreatment and three additional time points during therapy. The presence of ≥5 CTCs per 7.5 mL of blood was considered CTC positive. Association of CTCs with progression-free survival (PFS) and overall survival (OS) was assessed using Cox regression models. Results: Of 343 patients treated, 294 had CTC data and were included in this analysis. Median follow-up was 39 months. In multivariable analysis, CTC-positive patients at baseline (31%) had significantly reduced PFS [HR, 1.49; 95% confidence interval (CI), 1.12–1.97] and OS (HR, 2.08; 95% CI, 1.49–2.93) compared with CTC negative. Failure to clear CTCs during treatment was associated with significantly increased risk of progression (HR, 2.2; 95% CI, 1.58–3.07) and death (HR, 3.4; 95% CI, 2.36–4.88). CTC-positive patients who received only letrozole had the worse PFS (HR, 2.3; 95% CI, 1.54–3.47) and OS (HR, 2.6; 95% CI, 1.59–4.40). Median PFS in CTC-positive patients was significantly longer (18.0 vs. 7.0 months) in letrozole plus bevacizumab versus letrozole arm (P ¼ 0.0009). Restricted mean survival time analysis further revealed that addition of bevacizumab was associated with PFS benefit in both CTC-positive and CTC-negative patients, but OS benefit was only observed in CTC-positive patients. Conclusions: CTCs were highly prognostic for the addition of bevacizumab to first-line letrozole in patients with HRþ MBC in CALGB 40503. Further research to determine the potential predictive value of CTCs in this setting is warranted.
ЗАРУБЕЖНЫЙ ОПЫТ ПРАВОВОГО РЕГУЛИРОВАНИЯ НАКАЗАНИЙ В ВИДЕ ОБЯЗАТЕЛЬНЫХ, ИСПРАВИТЕЛЬНЫХ И ПРИНУДИТЕЛЬНЫХ РАБОТ
Creators: name: А. Коряк
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: зарубежный опыт
правовое регулирование
уголовное наказание
обязательные работы
общественные работы
исправительные работы
принудительные работы
каторжные работы

description: В статье проводится анализ зарубежного опыта правового регулирования наказаний, аналогичных наказаниям в виде обязательных, исправительных и принудительных работ российского уголовного законодательства. Осуществляется сравнение уголовных наказаний, связанных с привлечением к труду осуждённых в зарубежном и российском уголовном праве. Делается вывод о том, что применение общественных (в меньшей степени – исправительных работ) предусмотрено современным уголовным законодательством большинства стран; в то время как принудительные работы не нашли широкого применения как уголовно-правовая мера исправления осуждённого
Mott Physics in Correlated Nanosystems: Localization-Delocalization Transition of Electrons by Exact Diagonalization Ab Initio Method
Creators: name: Spałek, Józef
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: The electronic states of selected nanosystems are discussed within the Exact Diagonalization Ab Initio (EDABI) method. In particular, incipient Mott--Hubbard localization effects and associated with it properties analyzed in detail.
ОСОБЕННОСТИ НАЗНАЧЕНИЯ И ОРГАНИЗАЦИИ ПРОИЗВОДСТВА КОМПЛЕКСНЫХ СУДЕБНЫХ ЭКСПЕРТИЗ
Creators: name: И. К. Кудрявцев
name: Э. А. Аймуратова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: судебная экспертиза
комплексная экспертиза
методика комплексной судебной экспертизы
специальные знания
эксперт

description: Статья посвящена комплексной судебной экспертизе, которая является одной из форм использования специальных знаний в уголовном судопроизводстве. Сегодня назначение и производство комплексных судебных экспертиз является достаточно сложным, не до конца изученным и отрегулированным процессом, поэтому необходимо его всестороннее изучение, выявление проблем и путей их решения. В статье раскрываются признаки, отличающие комплексную экспертизу от иных разновидностей, анализируются спорные вопросы ее назначения и производства.
Perception of healthcare utilization among individuals with Sickle Cell Disease (SCD): A scoping review
Creators: name: Meda, Shreya
name: Sukruthi Thunga
name: Gyamfi, Joyce
name: Nousheen Inayat
name: Peprah, Emmanuel
name: Noble, Elizabeth
name: Ruan, Christina
name: Dorice Vieira
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Business
subject: Public Health
subject: Medicine and Health Sciences
subject: Life Sciences
subject: Communication Sciences and Disorders
subject: Medical Education
subject: Bioethics and Medical Ethics
subject: Genetics and Genomics
subject: #barriers
subject: #disparities
subject: #facilitators
subject: #health equity
subject: #healthcare utilization
subject: #perceptions
subject: #sicklecelldisease

description: Given that there is a decrease in the number of individuals seeking care under a physician, there is common agreemeent that those with chronic conditions subsequently shy away from seeking care. Black children who suffer from SCD have been found to be in the hospital for >40 days, bringing us to the conclusion that their symptoms are poorly managed and their avoidance towards the healthcare system stems from stigma, structural racism and etc. Therefore, this review will look what barriers and/or facilitators impact decrease utilization of healthcare among those affected by SCD in the United States
ПОНЯТИЕ И ЗНАЧЕНИЕ СУДЕБНОЙ ЭКСПЕРТИЗЫ ПРИ РАССЛЕДОВАНИИ УГОЛОВНЫХ ДЕЛ
Creators: name: И. К. Кудрявцев
name: А. А. Обыденнова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: судебная экспертиза
уголовное дело
расследование
административный процесс

description: В данной статье рассматривается понятие судебной экспертизы при расследовании уголовных дел. Описывается сущность судебных экспертиз, особенности проведения. Охарактеризованы цели и предмет, объекты судебных экспертиз. Обозначена необходимость проведения экспертиз, отражена важность их проведения в судебном и досудебном разбирательствах в уголовных процессах. Рассмотрены дискуссионные вопросы порядка проведения, назначения судебных экспертиз в уголовных делах
What Is the Real Impact of Estrogen Receptor Status on the Prognosis and Treatment of HER2-Positive Early Breast Cancer?
Creators: name: Carey, L.A.
name: Malorni, L.
name: Piccart, M.
name: Prat, A.
name: Caparica, R.
name: Brandão, M.
Publisher: name: American Association for Cancer Research Inc.
Year: 2020

description: HER2+ early breast cancer is a heterogeneous disease, comprising all the intrinsic breast cancer subtypes. The only biomarker available nowadays for anti-HER2 treatment selection is HER2 status itself, but estrogen receptor (ER) status is emerging as a robust predictive marker within HER2+ disease. In this Perspective, we discuss the biological and clinical differences between patients with HER2+/ER-positive (ER+) disease versus those with HER2+/ ER-negative (ER-neg) tumors, namely, short-term and long-term (>5 years after diagnosis) prognosis, response to neoadjuvant treatment and benefit from adjuvant anti-HER2–targeted therapies. We also address other possible biomarkers to be used for patient selection in future clinical trials, such as gene signatures, PAM50 subtypes, tumor-infiltrating lymphocytes, PIK3CA mutations, and changes in Ki67 score during treatment and discuss their limitations. Finally, we suggest new clinical trial designs that can have an impact on clinical practice, aiming to test treatment deescalation separately for patients with HER2+/ER+ and HER2+/ER-neg tumors. We also propose an integrated classification of HER2+ disease, comprising DNA, RNA, protein expression, and microenvironment characteristics, in order to identify those tumors that are truly “HER2-addicted” and may benefit the most from anti-HER2 treatment.
Integrating Biology and Access to Care in Addressing Breast Cancer Disparities: 25 Years’ Research Experience in the Carolina Breast Cancer Study
Creators: name: Sweeney, M.R.
name: Carey, L.A.
name: Emerson, M.A.
name: Earp, H.S.
name: Tipaldos, H.J.
name: Olshan, A.F.
name: Troester, M.A.
name: Bell, M.E.
name: Reeder-Hayes, K.E.
Publisher: name: Springer
Year: 2020

description: Purpose of Review: To review research on breast cancer mortality disparities, emphasizing research conducted in the Carolina Breast Cancer Study, with a focus on challenges and opportunities for integration of tumor biology and access characteristics across the cancer care continuum. Recent Findings: Black women experience higher mortality following breast cancer diagnosis, despite lower incidence compared to white women. Biological factors, such as stage at diagnosis and breast cancer subtypes, play a role in these disparities. Simultaneously, social, behavioral, environmental, and access to care factors are important. However, integrated studies of biology and access are challenging and it is uncommon to have both data types available in the same study population. The central emphasis of phase 3 of the Carolina Breast Cancer Study, initiated in 2008, was to collect rich data on biology (including germline and tumor genomics and pathology) and health care access in a diverse study population, with the long-term goal of defining intervention opportunities to reduce disparities across the cancer care continuum. Summary: Early and ongoing research from CBCS has identified important interactions between biology and access, leading to opportunities to build greater equity. However, sample size, population-specific relationships among variables, and complexities of treatment paths along the care continuum pose important research challenges. Interdisciplinary teams, including experts in novel data integration and causal inference, are needed to address gaps in our understanding of breast cancer disparities.
Wideband saturable absorption in few-layer molybdenum diselenide (MoSe2) for Q-switching Yb-, Er- and Tm-doped fiber lasers
Creators: name: Woodward, R. I.
name: Howe, R. C. T.
name: Runcorn, T. H.
name: Hu, G.
name: Torrisi, F.
name: Kelleher, E. J. R.
name: Hasan, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We fabricate a free-standing molybdenum diselenide (MoSe2) saturable absorber by embedding liquid-phase exfoliated few-layer MoSe2 flakes into a polymer film. The MoSe2-polymer composite is used to Q-switch fiber lasers based on ytterbium (Yb), erbium (Er) and thulium (Tm) gain fiber, producing trains of microsecond-duration pulses with kilohertz repetition rates at 1060 nm, 1566 nm and 1924 nm, respectively. Such operating wavelengths correspond to sub-bandgap saturable absorption in MoSe2, which is explained in the context of edge-states, building upon studies of other semiconducting transition metal dichalcogenide (TMD)-based saturable absorbers. Our work adds few-layer MoSe2 to the growing catalog of TMDs with remarkable optical properties, which offer new opportunities for photonic devices.
ТАМОЖЕННОЕ РЕГУЛИРОВАНИЕ ПЕРЕСЫЛКИ ТОВАРОВ В МЕЖДУНАРОДНЫХ ПОЧТОВЫХ ОТПРАВЛЕНИЯХ
Creators: name: Е. А. Кузнецова
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: таможенные органы
почтовые органы
международные почтовые отправления
таможенное декларирование
таможенное оформление

description: В данной статье в связи с ростом количества заказов различных товаров посредством сети Интернет, рассматривается вопрос не только самой процедуры и порядка пересылки почтовых отправлений, органов, участвующих в данном процессе и их компетенции, но также вопрос законодательной регламентации таможенного регулирования пересылки международных в почтовых отправлениях, видов международных почтовых отправлений и необходимых документов при осуществлении пересылки.
TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes
Creators: name: Hughes, M.E.
name: Wulf, G.M.
name: Carey, L.A.
name: Brufsky, A.
name: Wagle, N.
name: DeMeo, M.
name: Nanda, R.
name: Wolff, A.C.
name: Marcom, P.K.
name: Domchek, S.
name: Garber, J.E.
name: Shah, P.D.
name: Krop, I.E.
name: Yang, E.S.
name: Santa-Maria, C.A.
name: Vinayak, S.
name: Robson, M.E.
name: Ballinger, T.J.
name: Lin, N.U.
name: Melisko, M.
name: Tung, N.M.
name: Ventz, S.
name: Winer, E.P.
name: Jenkins, C.
name: D'Andrea, A.
Publisher: name: American Society of Clinical Oncology
Year: 2020

description: PURPOSE Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi), is approved for the treatment of human epidermal growth factor receptor 2 (HER2)–negative metastatic breast cancer (MBC) in germline (g)BRCA1/2 mutation carriers. Olaparib Expanded, an investigator-initiated, phase II study, assessed olaparib response in patients with MBC with somatic (s)BRCA1/2 mutations or g/s mutations in homologous recombination (HR)–related genes other than BRCA1/2. METHODS Eligible patients had MBC with measurable disease and germline mutations in non-BRCA1/2 HR-related genes (cohort 1) or somatic mutations in these genes or BRCA1/2 (cohort 2). Prior PARPi, platinum-refractory disease, or progression on more than two chemotherapy regimens (metastatic setting) was not allowed. Patients received olaparib 300 mg orally twice a day until progression. A single-arm, two-stage design was used. The primary endpoint was objective response rate (ORR); the null hypothesis (# 5% ORR) would be rejected within each cohort if there were four or more responses in 27 patients. Secondary endpoints included clinical benefit rate and progression-free survival (PFS). RESULTS Fifty-four patients enrolled. Seventy-six percent had estrogen receptor–positive HER2-negative disease. Eighty-seven percent had mutations in PALB2, sBRCA1/2, ATM, or CHEK2. In cohort 1, ORR was 33% (90% CI, 19% to 51%) and in cohort 2, 31% (90% CI, 15% to 49%). Confirmed responses were seen only with gPALB2 (ORR, 82%) and sBRCA1/2 (ORR, 50%) mutations. Median PFS was 13.3 months (90% CI, 12 months to not available/computable [NA]) for gPALB2 and 6.3 months (90% CI, 4.4 months to NA) for sBRCA1/ 2 mutation carriers. No responses were observed with ATM or CHEK2 mutations alone. CONCLUSION PARP inhibition is an effective treatment for patients with MBC and gPALB2 or sBRCA1/2 mutations, significantly expanding the population of patients with breast cancer likely to benefit from PARPi beyond gBRCA1/2 mutation carriers. These results emphasize the value of molecular characterization for treatment decisions in MBC.
Intracranial efficacy and survival with tucatinib plus trastuzumab and capecitabine for previously treated HER2-positive breast cancer with brain metastases in the HER2CLIMB trial
Creators: name: Bedard, P.L.
name: Anders, C.
name: Lin, N.U.
name: Bachelot, T.
name: Gelmon, K.
name: Zelnak, A.
name: Hamilton, E.
name: Oliveira, M.
name: Murthy, R.K.
name: An, X.
name: Winer, E.P.
name: Okines, A.
name: Chien, A.J.
name: Curigliano, G.
name: Hurvitz, S.
name: Conlin, A.
name: O'Regan, R.
name: Abramson, V.
name: Mayor, J.
name: DiGiovanna, M.P.
name: Paplomata, E.
name: Loi, S.
name: Loibl, S.
name: Carey, L.
name: Borges, V.
name: Cameron, D.
name: Mueller, V.
name: Wardley, A.
name: McGoldrick, S.
Publisher: name: American Society of Clinical Oncology
Year: 2020

description: PURPOSE In the HER2CLIMB study, patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer with brain metastases (BMs) showed statistically significant improvement in progression-free survival (PFS) with tucatinib. We describe exploratory analyses of intracranial efficacy and survival in participants with BMs. PATIENTS AND METHODS Patients were randomly assigned 2:1 to tucatinib or placebo, in combination with trastuzumab and capecitabine. All patients underwent baseline brain magnetic resonance imaging; those with BMs were classified as active or stable. Efficacy analyses were performed by applying RECIST 1.1 criteria to CNS target lesions by investigator assessment. CNS-PFS (intracranial progression or death) and overall survival (OS) were evaluated in all patients with BMs. Confirmed intracranial objective response rate (ORR-IC) was evaluated in patients with measurable intracranial disease. RESULTS There were 291 patients with BMs: 198 (48%) in the tucatinib arm and 93 (46%) in the control arm. The risk of intracranial progression or death was reduced by 68% in the tucatinib arm (hazard ratio [HR], 0.32; 95% CI, 0.22 to 0.48; P, .0001). Median CNS-PFS was 9.9 months in the tucatinib arm versus 4.2 months in the control arm. Risk of death was reduced by 42% in the tucatinib arm (OS HR, 0.58; 95% CI, 0.40 to 0.85; P 5 .005). Median OS was 18.1 versus 12.0 months. ORR-IC was higher in the tucatinib arm (47.3%; 95% CI, 33.7% to 61.2%) versus the control arm (20.0%; 95% CI, 5.7% to 43.7%; P 5 .03). CONCLUSION In patients with HER2-positive breast cancer with BMs, the addition of tucatinib to trastuzumab and capecitabine doubled ORR-IC, reduced risk of intracranial progression or death by two thirds, and reduced risk of death by nearly half. To our knowledge, this is the first regimen to demonstrate improved antitumor activity against BMs in patients with HER2-positive breast cancer in a randomized, controlled trial.
Socio-environmental predictive factors for discharge destination after inpatient rehabilitation in patients with stroke: a systematic review and meta-analysis
Creators: name: Chevalley, Odile
name: Truijen, Steven
name: Saeys, Wim
name: Opsommer, Emmanuelle
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: To identify which of the socio-environmental factors of patients with stroke are predictive for discharge to their home after inpatient rehabilitation. Because discharge planning is a key component of rehabilitation, it is important to recognize the predictive factors for a discharge home. Other systematic reviews demonstrated the value of functional outcome measures. This review adds to the current literature by assessing the predictive value of socio-environmental factors, which shape the context in which a person lives. We performed a systematic search in seven databases. Two independent reviewers selected studies and assessed them for methodological quality. We extracted data to estimate pooled odds ratio for household situation, social support, ethnicity and socioeconomic status. Forty studies were included. Significant estimates were found for living with others (OR 2.60; 95%CI 1.84–3.68), having support at home (OR 11.48; 95%CI 6.52–20.21), being married (OR 2.05; 95%CI 1.80–2.33) and living at home before stroke (OR 31.01; 95%CI 7.38–130.18). Living at home and benefiting from social support, including living with others, are important factors to consider during discharge planning after stroke. Further research should consider the impact of socioeconomic status.IMPLICATIONS FOR REHABILITATIONEvaluating the social and environmental factors of patients with stroke plays an important role in discharge planning.Next to functional status, caregiver availability (support at home) is among the strongest predictive factors for discharge home.To assess caregiver availability, the presence of a willing and able caregiver should be surveyed at admission.Further predictive factors for discharge home are cohabitation and marital status. Evaluating the social and environmental factors of patients with stroke plays an important role in discharge planning. Next to functional status, caregiver availability (support at home) is among the strongest predictive factors for discharge home. To assess caregiver availability, the presence of a willing and able caregiver should be surveyed at admission. Further predictive factors for discharge home are cohabitation and marital status.