cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk stratification in prostate cancer using pH imaging
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The central goal of this application is to validate and optimize new method we have developed for imaging of tissue pH using magnetic resonance imaging (MRI) in preparation for future clinical studies. Prostate cancer presents with a broad clinical spectrum ranging from indolent to aggressive disease, and the development of biomarkers for improved discrimination between these phenotypes is an unmet clinical need and active area of research. One potential biomarker for aggressive disease is reduced interstitial (extracellular) pH, which is associated with local invasion, metastasis, and survival in murine models of cancer. We have recently developed a high resolution, clinically translatable method of imaging extracellular pH using hyperpolarized 13C magnetic resonance imaging using 13C sodium bicarbonate (HP-BiC-MRI). Briefly, this method relies on administration of a sodium bicarbonate contrast agent which can be imaged on a clinical MRI scanner, and provides millimeter scale resolution imaging of extracellular tissue pH in living animals. We have performed initial validation studies in vitro and in mouse models of prostate cancer, and have strong preliminary data suggesting that decreased pH measured using our HP-MRI method is correlated with aggressive disease as determined through standard histologic analysis. The goal of this application is to complete a preliminary analysis linking decreased tissue pH with high grade disease in the TRAMP mouse model, and to optimize the production and analysis of the hyperpolarized contrast agent in preparation for submission of an investigational new drug (IND) application to the United States Food and Drug Administration. Importantly, since our contrast agent is sodium bicarbonate, which is already routinely administered to patients as part of clinical care, it is highly unlikely that toxicity of the contrast agent will limit development. If accomplished, the experiments outlined in this proposal would validate our new HP-BiC-MRI imaging method as a predictive biomarker for the presence of aggressive, potentially lethal disease, and lay the groundwork for a subsequent first in man application of the technique.
Synbranchidae Bonaparte 1835
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Synbranchiformes
Synbranchidae

description: Family Synbranchidae Bonaparte 1835 (Fig. 3K). Swamp Eels; Anguilas de Pantano, Anguilas de Lodo, Anevilas, Anguilas Falsas
Description: Body elongate, eel-shaped, more or less rounded in cross section; up to 100 cm in length; scales absent; eyes small (some species functionally blind with eyes sunken below skin); anterior and posterior nostrils widely separated; pectoral and pelvic fins absent (pectorals present in early development of some species); dorsal and anal fins vestigial (reduced to a rayless ridge); caudal fin usually vestigial to absent (Nelson et al. 2016). Distribution: Tropical and subtropical freshwater, some species occasionally in brackish water (rarely marine); western Africa, Liberia, Asia, Indo-Australian Archipelago and from Mexico to South America (Nelson et al. 2016). Two genera and two species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 38, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
MOESM5 of Population structure and genomic inbreeding in nine Swiss dairy cattle populations
Creators: name: Signer-Hasler, Heidi
name: Burren, Alexander
name: Neuditschko, Markus
name: Frischknecht, Mirjam
name: Garrick, Dorian
name: Stricker, Christian
name: Gredler, Birgit
name: Bapst, Beat
name: Flury, Christine
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file 5: Figure S4. Distruct plot of the Admixture results for the nine Swiss cattle populations. Cross-validation error was lowest for k = 9 and 10, which indicates that k = 9 or 10 is the optimal number of clusters.
Dynamics of translational dysregulation in cancer.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Dysregulated translation is a hallmark of aberrant gene expression in cancer. Selective translation of oncogenes is promoted by hyper-efficient recognition of their mRNAs by the translation machinery. mRNA recognition is mediated by the eIF4F complex, which binds the mRNA 5' m7GpppN cap and facilitates loading of the mRNA onto the ribosome. eIF4F is a heterotrimer that scaffolds cap binding, mRNA structural remodeling, and ribosome recruitment; its activity is considered to limit the overall rate of translation for many mRNAs. Overexpression of eIF4E, the cap-binding subunit of eIF4F, by even two- to three-fold, leads to malignant transformation in a range of cells. Conversely, suppression of eIF4E expression to 60% of its initial level reverses malignant phenotypes. eIF4F is thus an attractive target of ongoing interest for therapeutics development. These efforts have been hindered by lack of key mechanistic information on translation: the eIF4F-mRNA complex and ribosome recruitment are highly dynamic, involving dramatic changes in molecular composition and conformation that resist analysis by most experimental techniques. We therefore still do not understand how eIF4F activities are kinetically coordinated on mRNA, or how differential coordination leads to differential ribosome recruitment and translation. Here we propose a biophysical and biochemical approach to define eIF4F dynamics that mediate oncogenesis. Our approach is focused on single-molecule fluorescence microscopy, which is uniquely suited to observing the real-time recognition of mRNA by human eIF4F, and key subsequent translation initiation steps. Building on preliminary studies with human eIF4E, we will first define and contrast eIF4F dynamics on oncogenic and non-oncogenic mRNAs. We will then establish the effects of molecular regulatory mechanisms on these dynamics, and how they are perturbed by eIF4F-targeted therapeutic leads. We will complement these data with biochemistry and enzymology to develop an integrated, quantitative mechanistic framework for regulated and dysregulated mRNA recognition. Our results will be a springboard toward our long-term goals of developing a detailed molecular model of translational (dys)regulation in cancer, bridging the gap between in vivo data and structural biology, and informing the design and characterization of therapeutics.
Control of cell growth in normal and transformed cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer cells show severe defects in control of cell growth and size, yet the underlying causes are unknown. The long-term goal of our work is to discover how control of cell growth and size works in normal cells, and how it goes wrong in cancer cells. With this knowledge, we hope to identify novel vulnerabilities of cancer cells that can be exploited to improve therapies. Our work thus far has focused on budding yeast, since it provides a simple and powerful system in which to discover fundamental mechanisms of cell size control. In our recent work, we discovered that a highly conserved signaling network that surrounds TOR kinase complex 2 (TORC2) controls both cell growth and cell size. The network includes tumor suppressors, as well as numerous kinases directly involved in critical oncogenic signaling pathways. Our discovery that cell growth and size are controlled by a conserved signaling network that is known to be disrupted in cancer suggests that we are close to solving the mystery of why cancer cells show such severe defects in control of cell growth and size. We are now poised to translate our discoveries into vertebrate cells. We will test the hypothesis that key functions of the TORC2 network that we have discovered in yeast are conserved in vertebrates, and that they play important roles in oncogenic signaling. Successful completion of the Aims will provide fundamental new insights into the functions of important oncogenic signaling proteins, as well as insights into the poorly understood functions of the vertebrate TORC2 network.
Guests at their own home
Creators: name: Sela-Levavi, Shirli
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation explores the differences in constructions of memory and of authorship in diasporic and national literature through a close reading of “A Guest for the Night” by S.Y. Agnon and the Yash novels by Jacob Glatstein. The reading is premised on a diasporic conception of Jewish literature as a cosmopolitan web of centers of production, interacting with each other. The two authors write in similar circumstances about visiting the Eastern European home in the interwar period. Both emigrated from Eastern Europe to Palestine and the United States respectively and their modernist homecoming narratives present the dilemmas of Jewish authorship on the cusp of modernity.  The discussion of memory reveals its interactions with place, language and peoplehood. The novels present a rupture in Jewish memory as a result of the upheavals of emmigration and the demise of traditional Jewish life. The authors ask questions about the continuity of Jewish narrative and life in face of changing relations to place and language. Agnon’s novel grapples with the transition from Diaspora to the ancient, historic homeland and explores the possibility of reconstructing Jewish life in it. At the same time Agnon interrogates the viability of Jewish life in a diasporic place. Agnon imiplicitly offers an alternative to the Zionist vision. His historical conception allows to mend the rupture in Jewish memory. Glatstein develops an alternative, highly flexible relation between memory and place and offers modes of commemoration that are not related to fixed locations and are based on language and culture.  The discussion of authorship looks at the way the authors see their own role in the transition from tradition to modernity. Agnon’s struggle with non traditional Jewish writing unfolds through his relations to different models of authorship. I explore his struggle with the romantic ideal of male authorship, and present this attempt as analogous to siring a new Jewish body in place of the dead and scattered exilic one. The discussion of Glatstein’s concept of authorship reveals a highly modernist, at times post modernist and performative conception of subjectivity. He presents the writer as performing a role, while using traditional themes of Yiddish theater as subcontext.
Yagansia grandis Zicsi 1993
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Acanthodrilidae
Yagansia
Yagansia grandis

description: Yagansia grandis Zicsi, 1993
Yagansia grandis Zicsi, 1993b Mitt. Hamb. Zool. Mus. Inst. 90: 170.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 14, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
LISONIY SHAXS SHAKLLANISHIDA PSIXOLOGIK OMILNING TA'SIRI
Creators: name: Saatova, Surayyo
Publisher: name: Zenodo
Year: 2024

description: Antroposentrik tilshunoslikda lisoniy shaxs bir qator sohalarning ajralmas obyekti hisoblanadi. So‘zlovchi inson tadqiqotlar diqqat markazida bo‘lar ekan, bu holat zamonaviy tilshunoslikda kommunikatsiya jarayoni, muomala madaniyati muammolarini shakllantirish uchun alohida ahamiyatga ega. Jamiyatda inson nutqiga ijtimoiy omillar bilan birga madaniy va psixologik omillar ham o‘z ta’sirini o‘tkazadi. Insonning nutqi u haqida ma’lumot berib, uning individual-psixologik xarakter xususiyatlarini ham ifodalaydi. Chunki jamiyatda kommunikatsiya jarayonida shaxsning psixologik, ma’naviy va ijtimoiy holati nutqining semantikasida yaqqol namoyon bo‘ladi. Bu o‘rinda linvopersonologiyaning psixolingvistika, lingvokulturologiya, sotsiolingvistika, etnolingvistika va boshqa shu kabi sohalar bilan bir nuqtada kesishishini taqozo qiladi. Bugungi kunda tilni yaratuvchi insonga bo‘lgan yangicha yondashuvlar lisoniy shaxsni har tomonlama o‘rganish uning muloqot jarayonida nutqiy xatti-harakatlariga yangicha qarashga imkon bermoqda.
Acrididae MacLeay 1821
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae

description: Family Acrididae
Fourteen subfamilies of Acrididae were studied. As a result of extensive surveys in Pakistan including its two adjacent territories, a total of 1,242 specimens were collected. Of the 169 species (including subspecies) of Acrididae belonging to 14 subfamilies, 29 tribes and 66 genera with distinct species counts, the subfamily Oedipodinae stands out as the largest subfamily, including 56 species. Gomphocerinae follows closely with 30 species, while Acridinae and Calliptaminae include 15 species and 12 species, respectively. Eyprepocnemidinae comes next with 12 species, Hemiacridinae with 10 species, and Oxyinae is represented by 9 species. Cyrtacanthacridinae is represented by 8 species, followed by Catantopinae with 7 species while Tropidopolinae and Teratodinae each includes 3 species. Spathosterninae includes 2 species, and Coptacrinae and Melanoplinae are each represented by a single species (Table.1). Among them, three were endemic species, 11 rare species, and seven species, e.g., Hieroglyphus concolor, Oxyina javana, O. sinobidentata, Oxya nitidula, Sphodromerus undulatus pedestris, Scintharista notabilis cinctipes, and Oedipoda fedtschenki fedtschenki are new records in the inventory of Pakistan, including five expected species and 18 with a debatable taxonomic position that were also known while the 12 taxa are currently in the process of identification and are not presented here.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 11, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Ophisternon aenigmaticum Rosen & Greenwood 1976
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Synbranchiformes
Synbranchidae
Ophisternon
Ophisternon aenigmaticum

description: Ophisternon aenigmaticum Rosen & Greenwood 1976. Obscure Swamp Eel; Anguila, Anguila de Pantano, Anguila de Suampo, Anguila de Lodo, Anevila, Anguila Falsa, Culebra, Anguila de Pantano Oscura
Vouchers: Not available. Distribution: North and Central America; from southern Mexico to northern Costa Rica, including Cuba and Trinidad and Tobago, Atlantic drainages; (Nicaragua) SJ and RF (Atlantic); 28–43 masl; Sec, Pot. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Villa (1982: 156; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Angulo (2021: 40; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 38, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
The design and implementation of cloud-scale live migration
Creators: name: Shu, Longhao
Publisher: name: No Publisher Supplied
Year: 2014

description: Live migration, short for live virtual machine (VM) migration, enables a running virtual machine to move between two physical hosts without perceptible interruption in service. Live migration is an efficient tool for system administrators to perform system maintenance, load balancing, and fault management while allowing end-users to avoid costly service downtimes. Today, live migration between hosts connected by a local area network (LAN) has become a critical feature of enterprise class virtual infrastructure.      We also expect live wide area network (WAN) migration, e.g., Cloud-scale live migration, to extend the scope of provisioning compute resources from a single data center to multiple geographically disparate data centers. Currently, Cloud-scale live migration is possible only through ad-hoc solutions using network file systems, proprietary storage array replication or software replicated block devices used in concert with more well known approaches for migrating memory. But this loose aggregation of mechanisms makes migration architectures complex, inflexible, and unreliable and performs poorly compared with live LAN migration in general.      To overcome those deficiencies, we present a Cloud-scale live migration framework that integrates support for memory and storage migration over WAN and maintains much of the simplicity and reliability of live LAN migration. The main challenge for implementing Cloud-scale live migration is how to deal with the large VM data (especially VM storage data) transferring over WAN. To solve this problem, we propose a new “Migration over FedEx” solution to combine the benefits of both live LAN migration and transferring large amount of data via shipping portable storage devices containing the data. Our solution capped the  total migration time into a bounded time period without increasing the downtime compared with traditional live migration. In the meanwhile, the total migration cost is greatly reduced especially for migrating large number of VMs.
The influence of small mammals on succession and restoration of post-agricultural wetlands
Creators: name: Shenko, Alicia Nicole
Publisher: name: No Publisher Supplied
Year: 2014

description: Advancements in modern industry and technology are creating an abundance of post-agricultural lands that are in need of skilled restoration efforts to manage the confluence of factors involved with whole-ecosystem functioning. The influence of small mammals in succession and restoration has been undervalued in traditional restoration studies. This study uses post-agricultural cranberry farms to help answer questions surrounding the role of small mammals in their succession and restoration. The first chapter investigates those species inhabiting post-agricultural wetlands and how they compare to more natural species assemblages in reference locations. Meadow voles (Microtus pennsylvanicus) were the most abundant species present and had a strong correlation to post-agricultural sites with wet habitat characteristics; the second-most abundant species present, white-footed mice (Peromyscus leucopus), had a strong correlation to sites with dry characteristics. Post-agricultural wetlands were more similar to each other than to any more natural reference locations. The second chapter investigates the diet of the meadow vole through microhistological fecal analysis and discusses the impact diet has on vegetative characteristics of post-agricultural wetlands. Meadow voles were found to ingest significant amounts of vegetation (grasses, sedges, rushes, leaves of shrubs, mosses), as well as minimal quantities tree leaves, shrub stems, flowers, fungus, seeds, and insects. Meadow vole herbivory on specific vegetation is evidence that high numbers of this species can alter characteristics of post-agricultural wetlands. The third chapter investigates the potential for small mammals to influence post-agricultural wetlands by dispersing seeds through defecation. Greenhouse trials had low rates of seedling establishment from meadow voles, but evidence suggests that this species has the ability to participate in endozoochory. The fourth chapter additionally investigates small mammal diet by proposing genetic methodology for exploring insectivory using unique regions of 18S rRNA and gel electrophoresis to distinguish insect orders by size. The ability to process this level of diet composition data without more expensive techniques such as sequencing would allow for expanded investigations at multiple levels. Overall, this research highlights the significant difference in small mammal species assembly within post-agricultural wetlands and the impact that these species can have when they occur in abundance within post-agricultural wetlands.
Changing political field structure and modulations in democarcy consolidation
Creators: name: Singh, Sourabh
Publisher: name: No Publisher Supplied
Year: 2014

description: In my research, I have empirically developed a theory regarding the relations among political structure, elite agency and democratization processes that overcomes the political structure/elite agency duality currently plaguing democracy consolidation studies. Using Bourdieu’s insights on the structure/agency relation to empirically examine the Nehruvian (194&-&1) and Gandhian (19&1-&&) periods of Indian democracy, I show that the elite’s role in democratization processes is shaped by their political habitus, which in turn is structured by historically specific political structures. Furthermore, neither the elite’s political habitus nor the political structures that influence it are immune to change. Political structures are shaped by intraparty conflicts among the elite to establish their political authority. Since political structures change because of the changing state of conflict among the political elite, the milieu in which the elite’s political habitus is conditioned also changes. In the changing political milieu, the existent elite’s political sensibilities are reconfigured, and the sensibilities of the new generation of political elite, who have differing interests in democratization processes, become mature. I have developed my theory by extensively studying the writings (letters, articles, party reports, etc.) and biographies of late colonial and early postcolonial political elites, as well as by compiling an original dataset of all 4,000 parliamentarians elected to the seven parliamentary sessions held during the 194&-84 period. I personally computerized this dataset by drawing information from the Data Handbook on Elections in India and Who’s Who of the Indian Parliament. I have used network analysis methods and logistic regression modeling, as well as content analysis of the political elite’s writings and biographies, to illustrate the consequences for Indian democracy because of the changing relation between political structures and the political elite’s habitus.
18FDOPA PET for the early evaluation of treatment responses
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Early pharmacodynamic biomarkers of therapeutic responses in cancer are critical to limit the amount of time clinicians and patients waste on ineffective therapies. This is especially true for glioblastoma, where the median survival time is 16 months and repeat biopsies are not possible. The use of 18F-FDG PET as an early pharmacodynamic biomarker of treatment responses is remarkably effective across various cancers and therapies, including for Imantinib in GIST and Erlotinib in lung cancer. However, unlike in most cancers where 18F-FDG PET can selectively differentiate tumor from normal tissue, glioblastoma cannot be easily distinguished from surrounding brain tissue with 18F-FDG PET. Instead the radiotracer 18F-FDOPA is used to visualize glioblastoma. 18F-FDOPA is a fluorinated analogue of the amino acid L-DOPA, and 18F-FDOPA accumulation measures L-DOPA consumption. We hypothesize that early changes in tumor 18F-FDOPA consumption in response to a therapy can predict a therapeutic response. We will test this in patient-derived gliomasphere models in culture. There is no published protocol for imaging patient-derived orthotopic xenograft models in mice with 18F-FDOPA PET to use in testing in vitro results in vivo. We propose to develop such a protocol and to test it with patient-derived xenografts. Successful completion of the proposal would lay the groundwork for a new approach to treating glioblastoma patients. The response of a tumor to a therapy would be evaluated early in the course of that therapy and patients would no longer be forced to endure ineffective therapies. In preliminary studies, we have (1) measured 18F-FDOPA consumption in culture in patient-derived gliomasphere models, (2) evidence that effective EGFR inhibition increases 18F-FDOPA consumption, and (3) experience 18F-FDOPA PET imaging subcutaneous glioblastoma models. We propose: (I) To test in culture, across 16 genetically diverse patient-derived gliomasphere models, whether changes in 18F-FDOPA consumption 4 or 24 hours post-treatment with an EGFR or PI3K inhibitor (1) correlate with drug – target engagement at those time points or (2) can predict therapeutic efficacy 72 hours post-treatment. (II) To develop a protocol for imaging patient-derived orthotopic glioblastoma xenograft models with 18F-FDOPA and use it to quantify 18F-FDOPA consumption in 6 models.
Planned organizational change in higher education
Creators: name: Smulowitz, Stacy
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation examined the introduction and implementation of an organizational Dashboard as a planned organizational change within four educational support service departments and the senior leadership group within a large, Northeastern university.  General systems theory provides a theoretical framework for conceptualizing planned organizational change and the role of communication in these processes (Bertalanffy, 1950; Thayer, 1968; Ruben, 1983).  Similarly, the role communication plays in the organizational stakeholder model of change implementation (Lewis, 200&) is used to understand these phenomenon.  Interviews from 32 participants were used in this case study.  Findings suggest the following themes: accountability- the way participants provide evidence to internal and external constituents about the impact of higher education (Zumeta, 2011); organizational changes- how members perceive a result or consequence of the Dashboard effort (Outcome, n.d.);  leadership issues- members’ perception of the presence, or lack thereof, of leadership commitment to the Dashboard effort (Commitment, n.d.) ;  information exchange- how members perceive the focus on the exchange of information about the Dashboard effort; and the overarching theme of communication- the process through which sensemaking and negotiation occur through social interactions (Berger & Luckmann, 196&).    Findings suggest that communication is necessary to understand planned organizational change and change effort strategies because people negotiate meanings of the change effort through communication and as a result their perceptions of the effort based on communication can stall, promote or halt the change effort itself (Ruben, 2009a).  Many of the three organizational levels of employees studied had different perceptions about the change effort because of their different perceptions of reality which stem from their membership in different organizational levels (Gallivan, 2001; Ruben, 19&9; Thayer, 19&9).  Findings also suggest the importance of leadership and continuous facilitation of the change effort.  A perceived shift in focus by leaders from the effort may be viewed by others in the organization as a lack of commitment which can stall or halt the effort.  A change agent of the effort is imperative to keep the leader visibly engaged and others in the organization actively focused on results, especially in loosely coupled organizations such as institutions of higher education.
Oncogenic potential of an alternate mRNA cap-binding protein
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Dysregulated translation promotes tumorigenesis, cancer progression and metastasis. Key oncogenic pathways such as PI3K/Akt/mTOR and MAPK/Mnk control protein synthesis by regulating eukaryotic translation initiation factor 4E1 (eIF4E1). This protein is encoded by a potent oncogene that is misregulated in up to 30% of human tumors and malignancies (1), and heterozygous loss of Eif4e1 in mice (Eif4e1+/-) increases resistance to cancer (2,3). The eIF4E1 protein directly binds the 5'-methylguanosine cap found at the 5' end of all cellular mRNAs as a component of the eIF4F complex. While eIF4E1 is thought to bind all mRNAs, oncogenic transcripts with highly structured 5' UTRs such as c-myc, VEGF, and cyclin D1 are very sensitive to eIF4E1 activity. Taken together, these results argue strongly that eIF4E1 plays a key role in cancer. Vertebrate genomes also encode a poorly-understood eIF4E1 homologue, eIF4E3, which has been suggested to act a tumor suppressor by competing with eIF4E1 and inhibiting the translation of cancer specific transcripts (4,5). In other cell culture models, eIF4E3 has been reported to support tumor growth by virtue of being refractory to regulatory signals impinging on eIF4E1 (6). We propose to investigate how eIF4E3 impacts translation and cancer cell survival in vivo. We will address this in the context of a natural tumor microenvironment by xenografting tumors with increased or reduced eIF4E3 and monitoring the progression of those tumors as well as profiling the translation occurring in the xenograft. Our experiments will test the hypothesis that eIF4E3, like eIF4E1, may serve as an effective target for anti-cancer therapy. 1 Volpon, Laurent, et al. Cell Cycle. 12(8), 1159–1160 (2013).?2 Mamane Yaël, et al. Oncogene 23(18) 3172–3179 (2004) 3 Truitt, Morgan L., et al. Cell. 162, 59–71 (2015). 4 Osborne, Michael J., et al. PNAS. 110(10), 3877-3882 (2013). 5 Joshi, Bhavesh, et al Eur. J. Biochem. 271, 2189-2203 (2004) 6. Landon, Ari, et al. Nature Comm. 5, 5413 (2014).
Acridinae MacLeay 1821
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae

description: Acridinae
(Fig.1)
Geographical Distribution: Pakistan (Ahmad 1958, 1980; Moeed 1971; Wagan 1990; Malik 1993; Suhail 1999; Soomro & Wagan 2005; Wagan & Sultana 2013; Sultana & Wagan 2015)
Comments
In Pakistan, the subfamily is represented by a few tribes (Acridini, Truxalini, and Phlaeobini), which are widely distributed throughout the country (Moeed 1966, Wagan 1990, Yousuf 1996, Suhail et al. 1999), occurring along roadsides, in agricultural crops, and near water channels. The species of Duroniella are found in cultivated fields among thick grasses in dry meadows, damp areas, and near roadsides, exhibiting significant color dimorphism. Some specimens display double bands on the head and pronotum, while others have a single band. Variations were also recorded in the lateral carinae of the pronotum. However, a thorough revision of the genus Duroniella is essential for a more comprehensive understanding. Acrida exaltata was the most dominant species of the Acridinae in terms of the number of individuals, constituting 26.05% of the total individuals, followed by Truxalis eximia at 18.48% and Phlaeoba infumata at 16.80%. Azem & Reshi (2010) documented two subtribes, Acridina and Phlaeobina, in Kashmir, India. To the best of our knowledge, Gilgit Baltistan remained unexplored until now. However, during the present expedition, P. rotundata and D. laticornis, as well as T. nasuta, were recorded in Gilgit Baltistan. We believe this marks the first report of Acridinae for Gilgit-Baltistan. Green-brown polymorphism is peculiar to Acrida. Roonwal (1970) observed the occurrence or absence of green-brown polymorphism in A. exaltata.
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 19, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Yagansia hajeki Zicsi 1989
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Acanthodrilidae
Yagansia
Yagansia hajeki

description: Yagansia hajeki Zicsi, 1989
Yagansia hajeki Zicsi, 1989a Acta Zool. Hung. 35 (3/4): 425.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 14, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Domain composition method and its applications
Creators: name: Song, Wei
Publisher: name: No Publisher Supplied
Year: 2014

description: Topology optimization methods have been fully developed during the past two decades, and it has achieved great success in the structural design field. In topology optimization, design domain is predetermined, and it keeps unchanged in structural optimization process. However, fixed design domain is difficult to satisfy some design requirements such as domain sizing adjustment or boundaries change.  In this dissertation, Domain Composition Method (DCM) is proposed to meet this challenge. Instead of treating design domain as a whole, DCM divides domain into several subdomains at the beginning. It defines additional scaling factors and applies subdomain transformations to describe the change between different designs. Then it composites subdomains and solve it as an updated domain. Consequently, structural analysis and sensitivity analysis can be derived. Furthermore, domain and topology of the structure are optimized simultaneously. Using DCM, regional strain energy formulation is discussed in protective structures design problem. Since the protective structures always undergo dynamic loads in practice, but the transient analysis is too expensive to apply, inertia relief analysis is employed to analyze the structure deformation. Some applications of DCM using regional strain energy formulation and inertia relief analysis are presented and discussed.  The main contributions of this dissertation are listed as follows: (1) presenting the concept of Design Composition Method (DCM), (2) applying DCM in static analysis and inertia relief analysis, (3) deriving the sensitivity of total strain energy and regional strain energy with DCM, (4) discussing the protective structures design scheme employing DCM using regional strain energy formulation and inertia relief analysis.
Synbranchus marmoratus Bloch 1795
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Synbranchiformes
Synbranchidae
Synbranchus
Synbranchus marmoratus

description: Synbranchus marmoratus Bloch 1795. Marbled Swamp Eel; Anguila, Anguila de Pantano, Anguila de Suampo, Anguila de Lodo, Anevila, Anguila Falsa, Culebra, Anguila de Pantano Moteada
Vouchers: UCR 0184-008 (2), 0190-006 (1), 0268-005 (1), 0275-004 (1), 0461-012 (4), 0539-004 (1), 0543-001 (4), 1056-002 (1) and 3131-002 (1); FMNH 314 (1); LSUMZ 15391 (1); other collections: CUMV 53917 (1), IBUNAM 13851 (1), KU 21651 (1), LACM 9738-1 (2), UMMZ 180623 (1) and 199640 (1), MVZ 30587 (1), SIO 15-2552 and (1) TCWC 254701. Distribution: North, Central and South America; from southern Mexico to northern Argentina, Atlantic and Pacific drainages; (Nicaragua) Co, UI, WK, Pr, GM, KP, Es, BF, IM, To, Sa, SJ, RF, LN (Atlantic), Ch, Ne, ER, PN and Ni (Pacific); 0–711 masl; Sec, Pot. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Astorqui (1975: 151; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 157; detailed description, including illustrations and an identification key, and information on distribution and ecology), Carr & Giovannoli (1994: 113; brief description, including information on distribution and ecology), Bussing (1998: 260; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Gros & Miguel-Frithz (2010: 211; brief description, including illustrations, and information on distribution and ecology, plus indigenous science and ethnoichthyology), van den Berghe (2015: 39; listed, including an illustration and information on distribution and ecology) and Angulo (2021: 40; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 38, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Enzyme triggered drug delivery for colorectal cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Colorectal cancer is the third most common cancer diagnosed in the U.S. population. Chemotherapy is often prescribed to patients diagnosed with advanced stage colorectal cancers when aggressive and sustained treatment is required. Site-specific drug delivery to tumors improve the local drug concentration, increasing chemotherapy efficacy. We popose to create site specifc drug delivery by leveraging the distinctive biochemical flora create by the dense bacterial microflora in colon. Specifically, we propose to use the microflora secreted azo-reductase enzyme to trigger the drug release from a nanoparticle at the targeted tumor site in the colon. The clinical use of silicone-based implants has paved the path for silicone-based materials for their use in drug delivery. However, these materials have not been studied for stimuli-responsive drug delivery to cancerous tumors. We will synthesize stimuli-responsive silicone-containing block copolymers to form drug encapsulating nanoparticles. These nanoparticles will be designed to undergo reduction in the presence of azo-reductase enzyme to effectively deliver the entrapped drug in the colon. In this study we aim to - 1. Synthesize a stimuli-responsive amphiphilic block copolymer of PDMS- azobenzene - PMOXA which can be chemically reduced by azo-reductases, 2. Prepare the stimuli-responsive polymeric nanoparticles to encapsulate chemotherapeutic agent 5-fluorouracil, 3. Investigate the drug release profiles of these nanoparticles in the presence of colon specific bacterial flora, and 4. Test the viability of cancer cells after the treatment with these nanoparticles in presence of microbial flora. This study will evaluate the potential of silicone-based nanoparticles for future applications in oral drug delivery (by encapsulating in enteric-coated capsule) to colorectal tumors, and for implantable drug delivery devices for chemotherapy via rectal route of administrations. Such localized drug delivery is expected to improve the effectiveness of chemotherapy and reduce the treatment related side effects.
Additional file 1: Table S1. of Neurally Adjusted Ventilatory Assist (NAVA) or Pressure Support Ventilation (PSV) during spontaneous breathing trials in critically ill patients: a crossover trial
Creators: name: Ferreira, Juliana
name: Diniz-Silva, Fabia
name: Moriya, Henrique
name: Alencar, Adriano
name: Amato, Marcelo
name: Carvalho, Carlos
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Patientâ  s ventilatory parameters at baseline. Ventilatory parameters for each study participant immediately before entering the trial. (DOCX 19Â kb)
Linking and characterizing biologic scales of imaging data
Creators: name: Sparks, Rachel
Publisher: name: No Publisher Supplied
Year: 2014

description: Prostate cancer is the second most commonly diagnosed cancer of men, an estimated 192,000 men are diagnosed each year in the United States (source: American Cancer Society). The current gold standard for prostate cancer diagnosis is pathologist inspection of prostate needle biopsy samples obtained using transrectal ultrasound (TRUS). TRUS-guided biopsy is routine because TRUS is widely available and acquires real-time imagery. However, TRUS-guided biopsy has a low sensitivity, and initial biopsy misses approximately half of all men with prostate cancer. Multi-parametric Magnetic Resonance Imaging (MRI) has shown promise in detecting, localizing, and grading prostate cancer. MRI-TRUS fusion, whereby MRI is acquired pre-operatively then aligned to TRUS during biopsy, allows for both modalities to be leveraged. MRI-TRUS fusion will enable the construction of joint classifiers, which leverage imaging characteristics on both MRI and TRUS, to detect, localize, and grade prostate cancer. In order to train and validate these classifiers, ground truth spatial extent and aggressiveness of prostate cancer must be obtained. Manual pathologist inspection provides the ultimate definitive diagnosis of prostate cancer, with the Gleason grading system providing a measure of prostate cancer aggressiveness. Therefore whole mount histopathology (WMH) is aligned to fused MRI-TRUS imagery to provide ground truth of cancer location and aggressiveness. A drawback to this approach is that Gleason grade is subject to inter- and intra-observer variability. Hence there is a need for reproducible, computer assisted grading of pathology which can serve as a surrogate for ground truth prostate cancer aggressiveness. In Aim 1 we develop a novel registration algorithm, multi-attribute probabilistic elastic registration (MAPPER), to align MRI and TRUS prostate imagery. In Aim 2 we align WMH with fused MRI-TRUS imagery (Aim 1). In Aim 3 we develop novel morphologic features to distinguish between aggressive and non-aggressive prostate cancer on histopathology. This will enable WMH to serve as ground truth for prostate cancer aggressiveness in order to train a MRI-TRUS classifier. Future work will leverage the tools developed to combine signatures of prostate cancer appearance across MRI, TRUS, and WMH and enable the development of tools to target biopsy to aggressive prostate cancer.
Rapid, Label-free Detection of Kidney Cancer by Urinalysis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The incidence of renal cell carcinoma (RCC), the most lethal urologic malignancy, is increasing and has more than doubled since 1975. RCC is generally discovered by the incidental observation of renal masses in abdominal images – no urine test or other screening modality for RCC is currently in use. In 2010, Morrissey and coworkers at WashU St. Louis identified two proteins – aquaporin-1 (AQP1) and perilipin-2 (PLIN2) – that are reliable urine-borne markers for RCC. Subsequent work from this group revealed that these two markers provide redundant information on the presence of RCC, including a correlation of the marker concentration (in the low nM range) with size of the tumor mass. This one-year CRCC project has three goals: 1) Adapt an existing electrochemical biosensor to detect AQP1 and PLIN2 in urine, 2) Compare biosensor performance using two types of receptors: monoclonal antibodies (commercially available) and engineered M13 virus particles (prepared in the G. Weiss group at UCI), 3) Using the receptor deemed to be superior, optimize the biosensor to blanket the diagnostic range required to correlate AQP1 and PLIN2 in urine with RCC. A new biosensor architecture called the Impedance Transduced Bioresistor or ITBR will be exploited in this study. The ITBR is a chemiresistor that consists of an electronically conductive polymer channel, 200-300 nm in thickness and 2 mm in length, into which are embedded receptors that can be either antibodies or M13 virus particles. Two electrical contacts to this channel allow its electrical impedance to be measured across 4 orders of magnitude in frequency, from 1 Hz to 10 kHz. When these receptors recognize and bind a target protein, an increase in the electrical impedance of the ITBR channel is measured and this “signal” can be correlated with the concentration of target with a high degree of precision (< 10% CoV, sensor to sensor). ITBRs using virus receptors are capable of measuring human serum albumin (HSA) in buffer or urine across the concentration range from 7 nM to 900 nM. The ITBR requires no "sandwich assay" or other means of signal amplification in order to function. A stable impedance signal suitable for quantitative analysis of the target is produced within 1-2 min. of exposure to a urine sample.