cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Generalized Penner models to all genera
Creators: name: Ambjorn, J.
name: Makeenko, Yu.
name: Kristjansen, C. F.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We give a complete description of the genus expansion of the one-cut solution to the generalized Penner model. The solution is presented in a form which allows us in a very straightforward manner to localize critical points and to investigate the scaling behaviour of the model in the vicinity of these points. We carry out an analysis of the critical behaviour to all genera addressing all types of multi-critical points. In certain regions of the coupling constant space the model must be defined via analytical continuation. We show in detail how this works for the Penner model. Using analytical continuation it is possible to reach the fermionic 1-matrix model. We show that the critical points of the fermionic 1-matrix model can be indexed by an integer, $m$, as it was the case for the ordinary hermitian 1-matrix model. Furthermore the $m$'th multi-critical fermionic model has to all genera the same value of $γ_{str}$ as the $m$'th multi-critical hermitian model. However, the coefficients of the topological expansion need not be the same in the two cases. We show explicitly how it is possible with a fermionic matrix model to reach a $m=2$ multi-critical point for which the topological expansion has alternating signs, but otherwise coincides with the usual Painlevé expansion.
description: 27 pages, PostScript
Nanoscale periodic domain patterns in tetragonal ferroelectrics: A phase-field study
Creators: name: Balakrishna, Ananya Renuka
name: Huber, John E.
name: Münch, Ingo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Ferroelectrics form domain patterns that minimize their energy subject to imposed boundary conditions. In a linear, constrained theory, that neglects domain wall energy, periodic domain patterns in the form of multi-rank laminates can be identified as minimum-energy states. However, when these laminates (formed in a macroscopic crystal) comprise domains that are a few nanometers in size, the domain-wall energy becomes significant, and the behaviour of laminate patterns at this scale is not known. Here, a phase-field model, which accounts for gradient energy and strain energy contributions, is employed to explore the stability and evolution of the nanoscale multi-rank laminates. The stress, electric field, and domain wall energies in the laminates are computed. The effect of scaling is also discussed. In the absence of external loading, stripe domain patterns are found to be lower energy states than the more complex, multi-rank laminates, which mostly collapse into simpler patterns. However, complex laminates can be stabilized by imposing external loads such as electric field, average strain and polarization. The study provides insight into the domain patterns that may form on a macroscopic single crystal but comprising of nanoscale periodic patterns, and on the effect of external loads on these patterns.
description: 13 pages, 14 figures, 2 tables
Solving the Strongly Coupled 2D Gravity: 2. Fractional-Spin Operators, and Topological Three-Point Functions
Creators: name: Gervais, Jean-Loup
name: Roussel, Jean-Francois
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Progress along the line of a previous article are reported. One main point is to include chiral operators with fractional quantum group spins (fourth or sixth of integers) which are needed to achieve modular invariance. We extend the study of the chiral bootstrap (recently completed by E. Cremmer, and the present authors) to the case of semi-infinite quantum-group representations which correspond to positive integral screening numbers. In particular, we prove the Bidenharn-Elliot and Racah identities for q-deformed 6-j symbols generalized to continuous spins. The decoupling of the family of physical chiral operators (with real conformal weights) at the special values C_{Liouville}= =7, 13, and 19, is shown to provide a full solution of Moore and Seiberg's equations, only involving operators with real conformal weights. Moreover, our study confirms the existence of the strongly coupled topological models. The three-point functions are shown to be given by a product of leg factors similar to the ones of the weakly coupled models. However, contrary to this latter case, the equality between the quantum group spins of the holomorphic and antiholomorphic components is not preserved by the local vertex operator. Thus the ``c=1'' barrier appears as connected with a deconfinement of chirality.
description: 45 pages Latex file, 14 figures (uuencoded)
МАРКЕТИНГОВЫЙ АНАЛИЗ КАРДИОТОНИЧЕСКИХ ПРЕПАРАТОВ В ФАРМАЦЕВТИЧЕСКОМ РЫНКЕ УЗБЕКИСТАНА
Creators: name: Эргашева, Ё.О.
name: Хасанова, Д.У.
name: Вахидова, Н.М.
name: Максудова, Ф.Х.
Publisher: name: Zenodo
Year: 2024

description: Проведен анализ фармацевтического рынка препаратов с кардиотоническим действием. Объектом исследования выбран Государственный Реестр лекарственных средств и медицинских изделий, зарегистрированных в Республике Узбекистан в период с 2021 по 2023 год. Проведено анализ количество зарегистрированных препаратов данной фармакотерапевтической группы, определены доли по производителям, учитывая лекарственные формы и природу активных веществ.
Notes of a twenty-five years' service in the Hudson's Bay Territory. In two volumes
Creators: name: McLean, John, 1799-1890
Publisher: name: London : Richard Bentley, Publisher in Ordinary to Her Majesty
Year: 2016

description: "'Depicts with great fidelity and vivacity the manners and condition, the toils, privations and perils of the Indian hunters' : Sabin.
 Chapters 18, 20 and 21 of vol.1 concern McLean's service in New Caledonia from 1833 to 1837.
 'Vocabulary of the principal Indian dialects in use among the tribes in the Hudson's Bay Territory [Sauteu, Cree, Beaver and Chippewayan]':- Vol.2, pp.323-328."-- Strathern, G. M., & Edwards, M. H. (1970). Navigations, traffiques & discoveries, 1774-1848: A guide to publications relating to the area now British Columbia. Victoria, BC: University of Victoria, p.188.
Rapport sur les missions du diocèse de Québec, et autres qui en ont ci-devant fait partie. Avril 1849. No. 8 ; avec approbation des supérieurs
Creators: name: Society For The Propagation Of The Faith
name: Catholic Church. Archdiocese Of Québec
Publisher: name: Québec : Imprimé par A. Côte et Cie, près l'Archevèché
Year: 2018

description: "Title varies. Nos.1 and 4. 1842, entitled Notice sur les missions du diocese de Quebec. They contain numerous reports on the work of the Catholic Church in the Oregon. Continued by the Association's Annales de la Propagation de la Foi pour la province de Quebec combining the reports of the dioceses of Québec and Montreal."-- Strathern, G. M., & Edwards, M. H. (1970). Navigations, traffiques & discoveries, 1774-1848: A guide to publications relating to the area now British Columbia. Victoria, BC: University of Victoria, p. 30.
Cascade circuit architecture for RF-photonic frequency multiplication with minimum RF energy
Creators: name: Hasan, Mehedi
name: Hinzer, Karin
name: Hall, Trevor
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A general RF-photonic circuit design for implementing frequency multiplication is proposed. The circuit consists of N cascaded differentially-driven Mach-Zehnder modulators biased at the minimum transmission point with a progressive RF phase shift of 180/N applied to each stage. The frequency multiplication factor obtained is 2N. The novelty of the design is the reduced input RF energy required in comparison to the functionally equivalent parallel MZM configuration. Using transfer matrix method, a N=3 architecture is modeled to obtain frequency sextupling. An industry standard simulation tool is used to verify the architectural concepts and analysis. The proposed design requires no optical or electrical filtering nor careful adjustment of the modulation index for correct operation. In addition, the overall intrinsic conversion efficiency of the N=3 cascade circuit is improved by 5 dB over a parallel MZM circuit. Finite MZM extinction and/or phase errors and power imbalances in the electric drive signals are also taken into consideration and their impact on overall performance investigated. The circuit can be integrated in any material platform that offers electro-optic modulators.
description: 9 pages, 5 figures, 1 table
Additional file 1 of Sarcopenia in the foot on magnetic resonance imaging in patients with diabetes mellitus – a systematic review
Creators: name: Ahmad, Manal
name: Mohamed, Abdulla
name: Amiras, Dimitri
name: Siracusa, Francesca
name: Shalhoub, Joseph
name: Davies, Alun Huw
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1.
Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics study
Creators: name: M Ramya Chandar Charles
name: Hsing-Pang Hsieh
name: Mohane Selvaraj Coumar
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Mono- and di-methylation of the H3K9 residue in the histone tail by G9a lysine methyltransferase is associated with transcriptional suppression of genes. Here, we use molecular dynamics simulation and free energy calculations of five different modified/mutated G9a substrate peptides to elucidate the rationale behind the substrate binding to G9a. We also investigated the binding energy contribution based architecture of the active site of G9a to understand substrate and inhibitor binding. Wild-type peptide (H3K9) shows better binding affinity than mono- and di-methylated lysine (K9) and other modified peptides (K9A and R8A). Arg8 of the substrate peptide is crucial for determining the degree of conformational freedom/stability of the wild-type substrate peptide, as well as binding to G9a. Our results also suggest that the G9a active site is segregated into energy rich and low regions, and the energy rich region alone is used by the inhibitors for binding. These insights into the active site architecture should be taken into consideration in virtual screening experiments designed to discover novel inhibitors for G9a. In particular, compounds that could interact with the six residues of G9a – Asp1074, Asp1083, Leu1086, Asp1088, Tyr1154 and Phe1158 – should be preferentially tested in G9a inhibition biological assays. Communicated by Ramaswamy H. Sarma
Western America, including California and Oregon, with maps of those regions, and of "the Sacramento Valley
Creators: name: Wilkes, Charles, 1798-1877
Publisher: name: Philadelphia : Lea and Blanchard
Year: 2016

description: "'Written from material gathered by the author on his famous government exploring expedition of 1832-4 [!] but not included in his 'Narrative' as this region was not then in the U.S. public domain':- Howes." -- Strathern, G. M., & Edwards, M. H. (1970). Navigations, traffiques & discoveries, 1774-1848: A guide to publications relating to the area now British Columbia. Victoria, BC: University of Victoria, p. 321-322.
ПСИХОНЕВРОЛОГИЧЕСКИЕ И ВЕГЕТАТИВНЫЕ ИЗМЕНЕНИЯ У ДЕВУШЕК В ПЕРИОД ФОРМИРОВАНИЯ И МЕНСТРУАЛЬНОГО ЦИКЛА
Creators: name: Абдуллаева, Н.Н.
name: Кенжаева, Д. К.
name: Курбанова, З.Х.
Publisher: name: Zenodo
Year: 2024

description: Самая распространенная и широко обсуждаемая проблема среди заболеваний нервной системы, считается вегетативные нарушения. Это связано с масштабным распространением заболевания, затруднением диагностики, трансформацией и маскированием под различные симптомы заболеваний, частым переходом в хроническую форму. По данным ВОЗ, с каждым годом возрастает процент людей с нестойкостью и лабильностью вегетативных нервной системы, и самое большое количество контингента занимает уровень среди подросткового периода, а в сравнение между гендерными различиями, преобладают девочки. Данная особенность взаимосвязана с нарушениями стабильного менструального цикла на вегетативную нервную систему у девочек-подростков. Исследования специалистов показывают, что такие нарушения могут способствовать дисфункции вегетативной нервной системы, что выражается в различных симптомах, включая головокружение, усталость, боли и проблемы с регуляцией сердечного ритма.
Group Theoretical Hidden Structure of Supergravity Theories in Higher Dimensions
Creators: name: Ravera, L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The purpose of my PhD thesis is to investigate different group theoretical and geometrical aspects of supergravity theories. To this aim, several research topics are explored: On one side, the construction of supergravity models in diverse space-time dimensions, including the study of boundary contributions, and the disclosure of the hidden gauge structure of these theories; on the other side, the analysis of the algebraic links among different superalgebras related to supergravity theories. In the first three chapters, we give a general introduction and furnish the theoretical background necessary for a clearer understanding of the thesis. We then move to the original results of my PhD research activity: We start from the development of the so called $AdS$-Lorentz supergravity in $D=4$ by adopting the so called rheonomic approach and discuss on boundary contributions to the theory. Subsequently, we focus on the analysis of the hidden gauge structure of supersymmetric Free Differential Algebras. More precisely, we concentrate on the hidden superalgebras underlying $D=11$ and $D=7$ supergravities, exploring the symmetries hidden in the theories and the physical role of the nilpotent fermionic generators naturally appearing in the aforementioned superalgebras. After that, we move to the pure algebraic and group theoretical description of (super)algebras, focusing on new analytic formulations of the so called $S$-expansion method. The final chapter contains the summary of the results of my doctoral studies presented in the thesis and possible future developments. In the Appendices, we collect notation, useful formulas, and detailed calculations.
description: 204 pages, 5 figures. Thesis discussed on February 8, 2018 for the Ph.D title achievement in Physics, carried out in the Politecnico di Torino Ph.D program in Physics (cycle 30th). It contains results and material already published in arXiv:1511.06245, arXiv:1606.07328, arXiv:1607.00373, arXiv:1609.05042, arXiv:1611.05812, arXiv:1701.04234, arXiv:1705.06251, arXiv:1801.08860
title: ADCO, Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Cart. 175 (11 H 479), 115 folios, f. 0078
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0078, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0078, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The employment of the people and the capital of Great Britain in her own colonies, at the same time assisting emigration and penal arrangements by undertaking a great national work; and thus opening the shortest road to the most extensive regions of wealth ever before at the command of any nation in the world (not regions of gold, but for commerce and industry), so that at no future period (within at least the imagination of man) will Great Britain have to complain either of too great a population on her soil, or too small a market for her labour. All this fully explained in a letter from Major Robert Carmichael-Smyth to his friend the author of "The Clockmaker," containing thoughts on the subject of a British colonial railway communication between the Atlantic and the Pacific, from the magnificent harbour of Halifax, in Nova Scotia (north-eastern America), to the mouth of Frazer's River, in New Caledonia (north-western America), or such other port as may be determined upon
Creators: name: Carmichael-Smyth, Robert
Publisher: name: London : W. P. Metchim
Year: 2015

description: "All this fully explained in a letter from Major Robert Carmichael-Smyth to his friend the author of 'The Clockmaker,' containing thoughts on the subject of a British colonial railway communication between the Atlantic and the Pacific, from the magnificent harbour of Halifax, in Nova Scotia (North-Eastern America), to the mouth of Frazer's River in New Caledonia (North-Western America), or such other port as may be determined upon." -- Title page.
 "Peel lists another issue in 1849 which appeared under title: A letter to the author of the Clockmaker . .. In 59 pages, without the author's name. Second edition: London, Frome, W. C. & I. Penny, 1885. viii, 70 p. In the second edition the preliminary pages with title are reversed; title begins: A letter from Major Robert Carmichael-Smyth ..." <<</er, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 3.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Cart. 168 (11 H 66), f. 0019r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0019r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0019r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Determination of potential selective inhibitors for ROCKI and ROCKII isoforms with molecular modeling techniques: structure based docking, ADMET and molecular dynamics simulation
Creators: name: Secinti, Burcu Bayel
name: Tatar, Gizem
name: Tugba Taskin Tok
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Rho-associated protein kinases (ROCKs) are a member of the serine/threonine protein kinase family and potential therapeutic target for various diseases. This enzyme has two isoforms, Rho-associated protein kinase I (ROCKI) and Rho-associated protein kinase II (ROCKII). They share an overall 65% homology in all amino acid sequence and 92% homology in kinase domains. Since, the kinase domains of ROCKI and ROCKII are highly conserved and similar, the discovery and design of isoform-selective inhibitors are more challenging. Thus, most currently available agents that is against ROCKs exhibit low selectivity and severe side effects. Therefore, this study aimed to elucidate the interaction of compounds that indicated high potential in experimental studies against ROCKI and ROCKII enzymes in the molecular level with molecular modeling techniques. Firstly, we determined the interaction property of catalytic sites of the ROCKs by analyzing with molecular docking. Based on these results, the best ligands (50 compounds) corresponding to experimental studies were selected, and then absorption, distribution, metabolism and excretion – toxicity (ADMET) analysis of these compounds were implemented. According to these study results, the compound 40 for ROCKI and the compound 50 for ROCKII were identified as selective and highly potent inhibitors. And finally, molecular dynamics (MD) simulations were performed for the stability of ROCKs with identified compounds. In the light of this study, it will be possible to treat diseases that ROCKs have a role by developing more effective and specific ROCK inhibitors. Communicated by Ramaswamy H. Sarma
Australian snakebite myotoxicity (ASP-23)
Creators: name: Johnston, Christopher I.
name: Isbister, Geoffrey K.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Myotoxicity is a recognised but poorly characterised effect of snake envenoming worldwide. We aimed to describe the clinical effects, complications and effectiveness of antivenom in myotoxicity from Australian snake envenoming. Patients were recruited to the Australian Snakebite Project (ASP), a prospective, observational study of patients with suspected or proven snakebite countrywide. After informed consent data is collected and stored in a dedicated database and blood samples are taken and stored. We included patients with envenoming and biochemical evidence of myotoxicity (peak creatine kinase [CK] > 1000 U/L). Snake species was determined by expert identification or venom specific enzyme immunoassay. Analysis included patient demographics, clinical findings, pathology results, treatment and outcomes (length of hospital stay, complications). 1638 patients were recruited January 2003–December 2016, 935 (57%) were envenomed, 148 developed myotoxicity (16%). Snake species most commonly associated with myotoxicity were Notechis spp. (30%), Pseudechis porphyriacus (20%) and Pseudechis australis (13%). Bite site effects occurred in 19 patients. Non-specific systemic symptoms occurred in 135 patients (91%), specific signs and symptoms in 83. In 120 patients with early serial CK results, the median peak CK was 3323 U/L (IQR;1050–785100U/L), the median time to first CK >500 U/L was 11.1 h and median time to peak CK of 34.3 h. White cell count was elevated in 136 patients (93%; median time to elevation, 4.9 h). 37 patients had elevated creatinine, six were dialysed. Two patients died from complications of severe myotoxicity. Antivenom given before the first abnormal CK (>500 U/L) was associated with less severe myotoxicity (2976 versus 7590 U/L). Non-envenomed patients with elevated CK had rapid rise to abnormal CK (median 3.5 h) and less had elevated WCC (32%). Myotoxicity from Australian snakes is relatively common and has systemic effects, with significant associated morbidity and mortality. CK is not a good early biomarker of mytoxicity. Early antivenom may play a role in reducing severity.
Splittable and unsplittable graphs and configurations
Creators: name: Bašić, Nino
name: Grošelj, Jan
name: Grünbaum, Branko
name: Pisanski, Tomaž
Publisher: name: arXiv
Year: 2018
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 51A20, 05B30

description: We prove that there exist infinitely many splittable and also infinitely many unsplittable cyclic $(n_3)$ configurations. We also present a complete study of trivalent cyclic Haar graphs on at most 60 vertices with respect to splittability. Finally, we show that all cyclic flag-transitive configurations with the exception of the Fano plane and the Möbius-Kantor configuration are splittable.
description: 19 pages, 10 figures
Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics study
Creators: name: Ramya Chandar Charles M
name: Hsing-Pang Hsieh
name: Mohane Selvaraj Coumar
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Mono- and di-methylation of the H3K9 residue in the histone tail by G9a lysine methyltransferase is associated with transcriptional suppression of genes. Here, we use molecular dynamics simulation and free energy calculations of five different modified/mutated G9a substrate peptides to elucidate the rationale behind the substrate binding to G9a. We also investigated the binding energy contribution based architecture of the active site of G9a to understand substrate and inhibitor binding. Wild type peptide (H3K9) shows better binding affinity than mono- and di-methylated lysine (K9) and other modified peptides (K9A and R8A). Arg8 of the substrate peptide is crucial for determining the degree of conformational freedom/stability of the wild type substrate peptide, as well as binding to G9a. Our results also suggest that the G9a active site is segregated into energy rich and low regions, and the energy rich region alone is used by the inhibitors for binding. These insights into the active site architecture should be taken into consideration in virtual screening experiments designed to discover novel inhibitors for G9a. In particular, compounds that could interact with the six residues of G9a – Asp1074, Asp1083, Leu1086, Asp1088, Tyr1154 and Phe1158 – should be preferentially tested in G9a inhibition biological assays.
Properties of the single Jovian planet population and the pursuit of Solar system analogues
Creators: name: Agnew, Matthew T.
name: Maddison, Sarah T.
name: Horner, Jonathan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: While the number of exoplanets discovered continues to increase at a rapid rate, we are still to discover any system that truly resembles the Solar system. Existing and near future surveys will likely continue this trend of rapid discovery. To see if these systems are Solar system analogues, we will need to efficiently allocate resources to carry out intensive follow-up observations. We seek to uncover the properties and trends across systems that indicate how much of the habitable zone is stable in each system to provide focus for planet hunters. We study the dynamics of all known single Jovian planetary systems, to assess the dynamical stability of the habitable zone around their host stars. We perform a suite of simulations of all systems where the Jovian planet will interact gravitationally with the habitable zone, and broadly classify these systems. Besides the system's mass ratio (Mpl/Mstar), and the Jovian planet's semi-major axis (apl) and eccentricity (epl), we find that there are no underlying system properties which are observable that indicate the potential for planets to survive within the system's habitable zone. We use Mpl/Mstar, apl and epl to generate a parameter space over which the unstable systems cluster, thus allowing us to predict which systems to exclude from future observational or numerical searches for habitable exoplanets. We also provide a candidate list of 20 systems that have completely stable habitable zones and Jovian planets orbiting beyond the habitable zone as potential first order Solar system analogues.
description: 14 pages, 10 figures
Probing the “fingers” domain binding pocket of Hepatitis C virus NS5B RdRp and D559G resistance mutation via molecular docking, molecular dynamics simulation and binding free energy calculations
Creators: name: Saravanan Manjula
name: Magudeeswaran Sivanandam
name: Poomani Kumaradhas
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 60506 Virology

description: The NS5B RdRp polymerase is a prominent enzyme for the replication of Hepatitis C virus (HCV). During the HCV replication, the template RNA binding takes place in the “fingers” sub-domain of NS5B. The “fingers” domain is a new emerging allosteric site for the HCV drug development. The inhibitors of the “fingers” sub-domain adopt a new antiviral mechanism called RNA intervention. The details of essential amino acid residues, binding mode of the ligand, and the active site intermolecular interactions of RNA intervention reflect that this mechanism is ambiguous in the experimental study. To elucidate these details, we performed molecular docking analysis of the fingers domain inhibitor quercetagetin (QGN) with NS5B polymerase. The detailed analysis of QGN-NS5B intermolecular interactions was carried out and found that QGN interacts with the binding pocket amino acid residues Ala97, Ala140, Ile160, Phe162, Gly283, Gly557, and Asp559; and also forms π⋯π stacking interaction with Phe162 and hydrogen bonding interaction with Gly283. These are found to be the essential interactions for the RNA intervention mechanism. Among the strong hydrogen bonding interactions, the QGN⋯Ala140 is a newly identified important hydrogen bonding interaction by the present work and this interaction was not resolved by the previously reported crystal structure. Since D559G mutation at the fingers domain was reported for reducing the inhibition percentage of QGN to sevenfold, we carried out molecular dynamics (MD) simulation for wild and D559G mutated complexes to study the stability of protein conformation and intermolecular interactions. At the end of 50 ns MD simulation, the π⋯π stacking interaction of Phe162 with QGN found in the wild-type complex is altered into T-shaped π stacking interaction, which reduces the inhibition strength. The origin of the D559G resistance mutation was studied using combined MD simulation, binding free energy calculations and principal component analysis. The results were compared with the wild-type complex. The mutation D559G reduces the binding affinity of the QGN molecule to the fingers domain. The free energy decomposition analysis of each residue of wild-type and mutated complexes revealed that the loss of non-polar energy contribution is the origin of the resistance. Communicated by Ramaswamy H. Sarma
There are No Causality Problems for Fermi's Two Atom System
Creators: name: Buchholz, Detlev
name: Yngvason, Jakob
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A repeatedly discussed gedanken experiment, proposed by Fermi to check Einstein causality, is reconsidered. It is shown that, contrary to a recent statement made by Hegerfeldt, there appears no causality paradoxon in a proper theoretical description of the experiment.
description: 6 pages, latex, DESY 94-027
Britain redeemed and Canada preserved
Creators: name: Wilson, F. A.
name: Richards, Alfred Bate, 1820-1876
Publisher: name: London : Longman, Brown, Green and Longmans
Year: 2015

description: "Proposes elaborate details for the construction of a railway to the Pacific as part of a scheme to decrease the criminal population of the United Kingdom and relieve pauperism." -- Lowther, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 3.
The ethnology of the British colonies and dependencies
Creators: name: Latham, R. G. (Robert Gordon), 1812-1888
Publisher: name: London : John Van Voorst
Year: 2015

description: "Has several pages on Pacific Northwest Indians." -- Lowther, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 4.

"Course of Six Lectures delivered at the Royal Institution, Manchester, in the months of February and March" -- Preface.
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00264
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00264, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
A Helium-Surface Interaction Potential of Bi$_2$Te$_3$(111) from Ultrahigh-Resolution Spin-Echo Measurements
Creators: name: Tamtögl, Anton
name: Pusterhofer, Michael
name: Bremholm, Martin
name: Hedegaard, Ellen M. J.
name: Iversen, Bo B.
name: Hofmann, Philip
name: Ellis, John
name: Allison, William
name: Miret-Artés, S.
name: Ernst, Wolfgang E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have determined an atom-surface interaction potential for the He$-$Bi$_2$Te$_3$(111) system by analysing ultrahigh resolution measurements of selective adsorption resonances. The experimental measurements were obtained using $^3$He spin-echo spectrometry. Following an initial free-particle model analysis, we use elastic close-coupling calculations to obtain a three-dimensional potential. The three-dimensional potential is then further refined based on the experimental data set, giving rise to an optimised potential which fully reproduces the experimental data. Based on this analysis, the He$-$Bi$_2$Te$_3$(111) interaction potential can be described by a corrugated Morse potential with a well depth $D=(6.22\pm0.05)~\mathrm{meV}$, a stiffness $κ=(0.92\pm0.01)~\mathrmÅ^{-1}$ and a surface electronic corrugation of $(9.6\pm0.2)$% of the lattice constant. The improved uncertainties of the atom-surface interaction potential should also enable the use in inelastic close-coupled calculations in order to eventually study the temperature dependence and the line width of selective adsorption resonances.
title: Translating twenty-first-century orchestral scores for the piano: transcription, reduction and performability
Creators: name: Štšura, M.
Publisher: name: Royal College of Music
Year: 2021

description: This research focusses on the technical and aesthetic issues surrounding the creation of piano reductions of the orchestral scores of two twenty-first-century piano concertos. It sets out a number of principles that might be applied more generally when producing comprehensive and musically convincing piano reductions of a range of contemporary orchestral scores. Two-piano versions of piano concertos enable performers to learn the content of the work before they have a chance to rehearse it with a full orchestra and thus to gain a better understanding of the solo piano’s position within the overall texture. At their best, these arrangements can provide a satisfying alternative to the full orchestral performance. Since the early nineteenth century, piano arrangements of orchestral works have been instrumental in the process of studying and disseminating not only symphonic music but also other orchestral genres such as operas and concertos. In the first half of the twentieth century composers including Stravinsky, Ravel and Bartók produced their own piano reductions, of their instrumental concertos and symphonic works. By the late twentieth century, major changes in both musical language and orchestration complicated the straightforward ‘reduction’ of melodic, harmonic and rhythmic elements for piano. For example, percussion has become a far more prominent element of the musical fabric, and the use of extended techniques on string, woodwind and brass instruments is now practised widely. It is thus becoming increasingly challenging and time-consuming to transcribe orchestral scores of contemporary works for piano in such a way that convincingly captures their essential aural features. Inevitably, fundamental properties of the original, such as timbral and dynamic variety, are easily lost in the process of transcription. In my research, I investigate the possibilities of overcoming the acoustic and technical limitations of the piano as a vehicle for representing the modern orchestra and of creating practicable reductions that are both playable and faithful to the original acoustic impression. General observations and principles are demonstrated through the two case studies: full transcriptions of two stylistically contrasting twenty-first century piano concertos, by Mark-Anthony Turnage and James Dillon.
Classical Functional Bethe Ansatz for $SL(N)$: separation of variables for the magnetic chain
Creators: name: Scott, D. R. D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Functional Bethe Ansatz (FBA) proposed by Sklyanin is a method which gives separation variables for systems for which an $R$-matrix is known. Previously the FBA was only known for $SL(2)$ and $SL(3)$ (and associated) $R$-matrices. In this paper I advance Sklyanin's program by giving the FBA for certain systems with $SL(N)$ $R$-matrices. This is achieved by constructing rational functions $\A(u)$ and $\B(u)$ of the matrix elements of $T(u)$, so that, in the generic case, the zeros $x_i$ of $\B(u)$ are the separation coordinates and the $P_i=\A(x_i)$ provide their conjugate momenta. The method is illustrated with the magnetic chain and the Gaudin model, and its wider applicability is discussed.
description: 14pp LaTex,DAMTP 94-17
On-Demand Generation of Neutral and Negatively-Charged Silicon-Vacancy Centers in Diamond
Creators: name: Dhomkar, Siddharth
name: Zangara, Pablo R.
name: Henshaw, Jacob
name: Meriles, Carlos A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Point defects in wide-bandgap semiconductors are emerging as versatile resources for nanoscale sensing and quantum information science but our understanding of the photo-ionization dynamics is presently incomplete. Here we use two-color confocal microscopy to investigate the dynamics of charge in Type 1b diamond hosting nitrogen-vacancy (NV) and silicon-vacancy (SiV) centers. By examining the non-local fluorescence patterns emerging from local laser excitation, we show that in the simultaneous presence of photo-generated electrons and holes, SiV (NV) centers selectively transform into the negative (neutral) charge state. Unlike NVs, 532 nm illumination ionizes SiV- via a single photon process thus hinting at a comparatively shallower ground state. In particular, slower ionization rates at longer wavelengths suggest the latter lies approximately ~1.9 eV below the conduction band minimum. Building on the above observations we demonstrate on-demand SiV and NV charge initialization over large areas via green laser illumination of variable intensity.
A directory for the navigation of the Pacific Ocean; with descriptions of its coasts, islands, etc., from the Strait of Magalhaens to the Arctic Sea, and those of Asia and Australia; its winds, currents, and other phenomena. In two parts. Part II. The islands, etc., of the Pacific Ocean
Creators: name: Findlay, Alexander George, 1812-1875
Publisher: name: London : R. H. Laurie
Year: 2015

Abstract
The Wu-Yang Ambiguity Revisited
Creators: name: Freedman, Daniel Z.
name: Khuri, Ramzi R.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Several examples are given of continuous families of SU(2) vector potentials $A_i^a(x)$ in 3 space dimensions which generate the same magnetic field $B^{ai}(x)$ (with det $B\neq 0$). These Wu-Yang families are obtained from the Einstein equation $R_{ij}=-2G_{ij}$ derived recently via a local map of the gauge field system into a spatial geometry with $2$-tensor $G_{ij}=B^a{}_i B^a{}_j\det B$ and connection $Γ_{jk}^i$ with torsion defined from gauge covariant derivatives of $B$.
description: 12 pages, CERN-TH.7187/94, CTP#2282 (previous version missing acknowledgements)
Additional file 1 of Irisin deletion induces a decrease in growth and fertility in mice
Creators: name: Luo, Yunyao
name: Qiao, Xiaoyong
name: Ma, Yaxian
name: Deng, Hongxia
name: Xu, Charles C.
name: Xu, Liangzhi
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. The different MS/MS spectra of Akr1c18, Mamld1 and Cyp19a1 in Fndc5 mutant and WT mice are shown GH, IGF-1, IGFBP-2, IGFBP-3 and IGFBP-4 in Fndc5 mutant and WT mice are shown.
Smart Conversational Agents for Reminiscence
Creators: name: Nikitina, Svetlana
name: Callaioli, Sara
name: Baez, Marcos
Publisher: name: arXiv
Year: 2018
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: In this paper we describe the requirements and early system design for a smart conversational agent that can assist older adults in the reminiscence process. The practice of reminiscence has well documented benefits for the mental, social and emotional well-being of older adults. However, the technology support, valuable in many different ways, is still limited in terms of need of co-located human presence, data collection capabilities, and ability to support sustained engagement, thus missing key opportunities to improve care practices, facilitate social interactions, and bring the reminiscence practice closer to those with less opportunities to engage in co-located sessions with a (trained) companion. We discuss conversational agents and cognitive services as the platform for building the next generation of reminiscence applications, and introduce the concept application of a smart reminiscence agent.
Fairleigh Dickinson University's PublicMind: New Jersey November 2015 Poll
Creators: name: Fairleigh Dickinson University's PublicMind
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Reside in New Jersey (1); registered to vote (1); President Barack Obama job approval (1); country right direction/wrong track (1); New Jersey Governor Chris Christie job approval (1); New Jersey right direction/wrong track (1); trust which major political party in New Jersey more (1); pay inequity between men and women (2); presidential candidate matchups (4); favorability of New Jersey political figures (8); increase in state gasoline tax (4); purchase Jersey Fresh or locally grown fruits and vegetables (3); Canada geese (2); funds for preserving open spaces used for other environmental causes (1); favor raising amount of money not touched by estate tax (1); have a tattoo (1); body piercings other than ears (1); acceptable to wear facial jewelry at work (1); vote for Republican presidential candidates (1); vote for Democratic presidential candidates (1); miles driven each day (1); public employee pension system membership (1); Fairleigh Dickinson University (2).
Local Quantum Criticality of a One-Dimensional Kondo Insulator Model
Creators: name: Zhu, W.
name: Zhu, Jian-xin
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The continuous quantum phase transition and the nature of quantum critical point (QCP) in a modified Kondo lattice model with Ising anisotropic exchange interactions is studied within the density-matrix renormalization group algorithm. We investigate the effect of quantum fluctuations on critical Kondo destruction QCP, by probing static and dynamic properties of the magnetic order and the Kondo effect. In particular, we identify that local Kondo physics itself becomes critical at the magnetic phase transition point, providing unbiased evidences for local quantum criticality between two insulators without resorting to the change of Fermi surface.