cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 6 of Knockdown of TRPM7 prevents tumor growth, migration, and invasion through the Src, Akt, and JNK pathway in bladder cancer
Creators: name: Lee, Eun Hye
name: Chun, So Young
name: Bomi Kim
name: Yoon, Bo Hyun
name: Lee, Jun Nyung
name: Kim, Bum Soo
name: Yoo, Eun Sang
name: Sangkyu Lee
name: Song, Phil Hyun
name: Kwon, Tae Gyun
name: Ha, Yun-Sok
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 6. Fig. 1a beta-actin. Beta-actin of J82 and UMUC3 in Fig. 1a. Figure 1a TRPM7. TRPM7 of J82 and UMUC3 in Fig. 1a. Figure 1b beta-actin. Beta-actin of siRNA treated T24 in Fig. 1a. Fig. 1b, TRPM7_1. TRPM7 of siRNA treated T24 in Fig. 1b. Fig. 1b, TRPM7_2. TRPM7 of siRNA treated UMUC3 in Fig. 1b. Fig. 1b beta-actin. Beta-actin of siRNA treated UMUC3 in Fig. 1b. Figure 6a beta-actin-1. Beta-actin of siRNA treated T24 in Fig. 6a. Figure 6a p-Akt-1. p-Akt of siRNA treated T24 in Fig. 6a. Figure 6a p-JNK-1. p-JNK of siRNA treated T24 in Fig. 6a. Figure 6a p-Src-1. p-Src of siRNA treated T24 in Fig. 6a. Figure 6a t-Akt-1. t-Akt of siRNA treated T24 in Fig. 6a. Fig. 6a t-JNK-1. t-JNK of siRNA treated T24 in Fig. 6a. Fig. 6a t-Src-1. t-Src of siRNA treated T24 in Fig. 6a. Fig. 6a beta-actin-2. Beta-actin of siRNA treated UMUC3 in Fig. 6a. Fig. 6a p-Akt-2. p-Akt of siRNA treated UMUC3 in Fig. 6a. Fig. 6a p-JNK-2. p-JNK of siRNA treated UMUC3 in Fig. 6a. Fig. 6a p-Src. p-Src of siRNA treated UMUC3 in Fig. 6a. Fig. 6a t-Akt-2/ t-Akt of siRNA treated UMUC3 in Fig. 6a. Fig. 6a t-JNK-2/ t-JNK of siRNA treated UMUC3 in Fig. 6a. Fig. 6a t-Src. t-Src of siRNA treated UMUC3 in Fig. 6a.
Evaluation of jute leaf as substitute of fish meal in the diet of mrigal (Cirrhinus cirrhosus) fingerlings
Creators: name: Rana, K.M.S.
name: Biswas, P.
name: Salam, M.A.
name: Rana, K.M.S.
name: Biswas, P.
name: Salam, M.A.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agricultural and Food Policy
subject: Fish meal
subject: Isonitrogenous
subject: Jute leaf
subject: Mrigal

description: The study was conducted to identify jute leaf powder as an alternate to fish meal in diets of juvenile mrigal (Cirrhinus cirrhosus) for 60 days. Tossa jute (Corchorus olitorius) leaf was selected to utilize this unexplored nutritious resource rather leaving under water for potential pollution. Three isonitrogenous test diets were prepared and applied as treatments (T) in triplicates (R). In control (T0) dietary inclusion rate of fish meal was 30%, of which 10% was substituted with jute leaf powder in T10 and in T20 replacement was 20%. Mrigal fingerlings (9.38±0.13 cm and 7.94 ±0.26 g) were stocked in nine plastic half drums (0.26 m2 each) at 10 fish per drum and fed test diets. Although, growth parameters among the treatments were statistically similar, the highest mean length gain, weight gain, SGR and production were 1.51 (±0.18) cm, 2.96 (±0.13) g, 0.53 (±0.03) %/day and 4084.00 (±50.67) kg ha-1, respectively in T10. However, significantly higher (P<0.05) survival was found in T10 (93.33%) and T20 (90.00%) compared to T0 (83.33%). Juveniles in T10 and T20 showed better tolerance to low pH stress than T0. Water quality parameters were within acceptable range in all the treatments. Moreover, carcass composition of fish was statistically similar among the treatments. Importantly, feed formulation cost was reduced by 3.7% and 20.4% in T10 and T20, respectively compared to T0. Therefore, the results signify that jute leaf powder could be a promising substitute of fishmeal in mrigal diet without hampering growth along with improved survival and low feed cost.
Anomalously wide continuous tuning range of the emission frequency of an injection laser with an external selective resonator
Creators: name: Akulshin, A. M
name: Bazhenov, V. Yu
name: Velichanskii, V. L.
name: Zverkov, M. V.
name: Zibrov, A. S.
name: Nikitin, V. V.
name: Okhotnikov, O. G.
name: Sautenkov, V. A.
name: Senkov, N. V.
name: Yurkin, E. K.
Publisher: name: Swinburne
Year: 2024

description: A study was made of an anomalously wide continuous tuning range of the emission frequency of an injection laser with an external resonator operating under conditions of self-stabilized single-frequency lasing. The self-stabilization was observed for a large number of lasers with different structures, both at room and liquid nitrogen temperatures. A study was made of the influence of the power, degree of coupling with the external part of the laser, resonator length, and pass band of a selective component on the continuous tuning range. In the self-stabilization regime this range was 10-30 times greater than the corresponding range for a laser operating under conventional conditions. A nontrivial feature of hopping between longitudinal laser modes at the limit of the tuning range was observed. This feature was explained on the basis of a theory proposed by Bogatov, Eliseev, Okhotnikov, Rakhval'skii, and Khairetdinov [Sov. J. Quantum Electron. 13 , 1221 (1983)].
Exploring lay public and dental professional knowledge around HPV transmission via oral sex and oral cancer development
Creators: name: Brondani, Mario
name: Siqueira, Adriana B
name: Alves, Claudia M C
Publisher: name: BioMed Central
Year: 2019

description: Background: Human papillomavirus (HPV) has been associated with certain types of oropharyngeal cancers and yet, the level of knowledge that dental professionals and the lay public have in terms of HPV transmission, oral sexual activities, and oral cancer development needs exploration. The aim of this study was to assess the knowledge held by practicing dental professionals as well as the lay public regarding Human Papillomavirus (HPV) transmission through oral sex and subsequent oropharyngeal cancer development. Methods: Textual data were collected from a public forum with dental professionals in. Vancouver, who discussed the HPV-oral sex-oral cancer triad, and from survey data gathered from 212 lay public participants (also in Vancouver) who answered a 13-item questionnaire on the perceived risks of oral sex in terms of HPV infection and oropharyngeal cancer development. The data were analyzed statistically by age group, gender, and sexual orientation using descriptive statistics, while an ANOVA test was used to compare variation in the responses to the survey (p-value = 0.05). Results: The forum engaged 46 health care professionals, many of whom were aware of the potential risks for head and neck cancer development due to HPV infection, while also questioning “how to effectively talk about HPV with patients.” The survey revealed that 34.5% of the participants believed that oral sex is an activity with no or low risk for the transmission of HPV, while 84% of participants believed the same sexual practices were of low or no-risk for HIV (Human Immunodeficiency Virus) transmission. Most participants (82%) never discussed oral sexual activities with their physicians or dentists/dental hygienists. Conclusions: The general public remains mostly unaware of the potential links between HPV infection and oropharyngeal cancer. Physicians and dental providers should discuss oral sexual practice with their patients to raise awareness.
The Zero Pollution Action Plan as a chance for a cross-regulatory approach to pollution prevention and reduction
Creators: name: Conrad, André
name: Hildebrandt, Sophia
name: Klauk, Anja
name: Langner, Marcel
name: Schubert, Tim
name: Schulte, Christoph
name: Schwan, Johannes
name: Suhr, Michael
name: Tietjen, Lars
name: Vierke, Lena
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Wasser
subject: Boden
subject: Luft
subject: Chemikalien
subject: Monitoring
subject: Digitalisierung
subject: Zero Pollution Ambition
subject: boden
subject: Chemikalien
subject: Luft
subject: Gesundheit
subject: Wasser
subject: Nachhaltigkeit | Strategien | Internationales
subject: Chemicals
subject: Air
subject: Health
subject: Water
subject: Sustainability | Strategies | International matters
subject: Boden | Fläche
subject: Soil | Land
subject: Verkehr
subject: Transport

description: To further prevent and reduce the pollution of air, water, and soil and to safeguard human health and well-being, the European regulatory framework needs to be improved to include a cross-regulatory approach. This scientific opinion paper presents such an approach for the systemic protection of air, water, soil and human health- the Zero Pollution Ambition Cycle developed by the German Environment Agency (UBA)- The implementation of the measures announced by the European Commission within the EU Action Plan 'Towards Zero Pollution for Air, Water and Soil' published in May 2021 is an excellent opportunity for the different stakeholders for further developing and applying this integrated approach. Source: www.umweltbundesamt.de
description: To further prevent and reduce the pollution of air, water, and soil and to safeguard human health and well-being, the European regulatory framework needs to be improved to include a cross-regulatory approach. This scientific opinion paper presents such an approach for the systemic protection of air, water, soil and human health – the Zero Pollution Ambition Cycle developed by the German Environment Agency (⁠UBA⁠). The implementation of the measures announced by the European Commission within the EU Action Plan ‘Towards Zero Pollution for Air, Water and Soil’ published in May 2021 is an excellent opportunity for the different stakeholders for further developing and applying this integrated approach.
Enfants policiers
Creators: name: Poisson, Caroline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Enfants policiers
Police
Enfant
Droit International
Droit international humanitaire

description: Peu d’information existe au sujet des enfants qui exercent le travail de policier. Cette thèse tente de définir le terme enfant policier avec l’aide de différentes sciences ayant étudié l’enfant ainsi que le métier de policier. Par ailleurs, l’étude de conventions internationales aide à déterminer le cadre juridique pouvant règlementer le travail des enfants comme policiers. Afin d’illustrer ces propos, plusieurs exemples de pays sont donnés dans le but de démontrer les diverses circonstances où des enfants sont policiers. Finalement, des recommandations sont émises pour mieux encadrer la situation pouvant être qualifiée de dangereuse pour l’enfant et la communauté dans laquelle se retrouve cet enfant.
Sanctuaries and Cults of Artemis in Post-liberation Messene: Spartan Mimeses?
Creators: name: Loube, Heather Maureen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Artemis
Lakonia
Messenia
Greece
Religion

description: This dissertation is a comparative study of the relationship between the sanctuaries and cults of Artemis in Lakonian and Messenia, after the liberation of Messenia from Lakonia (370 BCE). Four hypotheses are explored in order to answer the central question of whether the sanctuaries and cults of Artemis in Messenia after the liberation were mimeses of those in Lakonia: essential religious similarity from the fourth century onwards, post-liberation Messenian revival of pre-conquest religious practices, conscious Messenian determination of religious difference from Lakonia and independent evolution of Messenian sanctuaries and cults of Artemis. From literary, archaeological, epigraphic and numismatic evidence as well as observations made during personal visits to sites and museums in Greece, relevant data on the physical and historical landscape, This dissertation is a comparative study of the relationship between the sanctuaries and cults of Artemis in Lakonia and Messenia, after the liberation of Messenia from Lakonia (370 BCE). Four hypotheses are explored in order to answer the central question of whether the sanctuaries and cults of Artemis in Messenia after the liberation were mimeses of those in Lakonia: essential religious similarity from the fourth century onwards, post-liberation Messenian revival of pre-conquest religious practices, conscious Messenian determination of religious difference from Lakonia and independent evolution of Messenian sanctuaries and cults of Artemis. From literary, archaeological, epigraphic and numismatic evidence as well as observations made during personal visits to sites and museums in Greece, relevant data on the physical and historical landscape, epicleseis, sanctuary components, relevant myths and cult practices of all Artemisia in the southern Peloponnese are assembled into two comprehensive catalogues, one for each polity. A synthesis and analysis of that data is then conducted to establish patterns for purposes of comparison. The emergent patterns demonstrate that sanctuaries and cults of Artemis in post-liberation Messene are not essentially Lakonian mimeses. This study advances our collective understanding of sanctuaries and cults of Artemis in Lakonia and Messenia. It points to unknowns which could provide fertile avenues for future research into the complexity and diversity of ancient Greek religion in the Peloponnese.
A novel fibroblast reporter cell line for in vitro studies of pulmonary fibrosis
Creators: name: Nemeth, Julia
name: Schundner, Annika
name: Quast, Karsten
name: Winkelmann, Veronika Eva
name: Frick, Manfred
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: TGF-b
subject: alpha smooth muscle actin
subject: DDC 610 / Medicine & health
subject: Idiopathic pulmonary fibrosis
subject: Myofibroblasts
subject: Lung
subject: Transforming Growth Factor beta
subject: Extracellular matrix
subject: Idiopathische pulmonale Fibrose
subject: Myofibroblast
subject: Lunge
subject: Extrazelluläre Matrix
subject: Transforming Growth Factor beta

description: Idiopathic pulmonary fibrosis (IPF) is a fatal disease of the lower respiratory tract with restricted therapeutic options. Repetitive injury of the bronchoalveolar epithelium leads to activation of pulmonary fibroblasts, differentiation into myofibroblasts and excessive extracellular matrix (ECM) deposition resulting in aberrant wound repair. However, detailed molecular and cellular mechanisms underlying initiation and progression of fibrotic changes are still elusive. Here, we report the generation of a representative fibroblast reporter cell line (10-4ABFP) to study pathophysiological mechanisms of IPF in high throughput or high resolution in vitro live cell assays. To this end, we immortalized primary fibroblasts isolated from the distal lung of Sprague-Dawley rats. Molecular and transcriptomic characterization identified clone 10-4A as a matrix fibroblast subpopulation. Mechanical or chemical stimulation induced a reversible fibrotic state comparable to effects observed in primary isolated fibroblasts. Finally, we generated a reporter cell line (10-4ABFP) to express nuclear blue fluorescent protein (BFP) under the promotor of the myofibroblast marker alpha smooth muscle actin (Acta2) using CRISPR/Cas9 technology. We evaluated the suitability of 10-4ABFP as reporter tool in plate reader assays. In summary, the 10-4ABFP cell line provides a novel tool to study fibrotic processes in vitro to gain new insights into the cellular and molecular processes involved in fibrosis formation and propagation.
Regulation of Neural Precursor Self-renewal via E2F3-dependent Transcriptional Control of EZH2
Creators: name: Pakenham, Catherine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: E2F3
EZH2
neural stem cells
neural precursor cells
p16
Sox2
Polycomb group proteins

description: Our lab has recently found that E2F3, an essential cell cycle regulator, regulates the self-renewal capacity of neural precursor cells (NPCs) in the developing mouse brain. Chromatin immunoprecipitation (ChIP) and immunoblotting techniques revealed several E2F3 target genes, including the polycomb group (PcG) protein, EZH2. Further ChIP and immunoblotting techniques identified the neural stem cell self-renewal regulators p16INK4a and Sox2 as shared gene targets of E2F3 and PcG proteins, indicating that E2F3 and PcG proteins may co-regulate these target genes. E2f3-/- NPCs demonstrated dysregulated expression of EZH2, p16INK4a, and SOX2 and decreased enrichment of PcG proteins at target genes. Restoring EZH2 expression to E2f3+/+ levels restores p16INK4a and SOX2 expression levels to near E2f3+/+ levels, and also partially rescues NPC self-renewal capacity toward E2f3+/+ levels. Taken together, these results suggest that E2F3 controls NPC self-renewal by modulating expression of p16INK4a and SOX2 via regulation of PcG expression, and potentially PcG recruitment.
Antagonism Between Trastuzumab and Oncolytic VSV is Overcome by Conjugation to a Microtubule Destabilizer
Creators: name: Garcia, Vanessa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Cancer
VSV
oncolytic virus
trastuzumab
trastuzumab emtansine
Kadcyla
Herceptin
HER2
breast cancer
ovarian cancer
microtubule
microtubule destabilizer
antagonism

description: HER2overexpression is associated with poor breast cancer prognosis and increased risk of metastasis. Current HER2targeted therapies include monoclonal antibody based strategies which work by reducing HER2 levels at the cell surface (trastuzumab), by preventing HER2 dimerization (pertuzumab), or via targeted delivery of a cytotoxic payload (trastuzumab emtansine). Although these therapies are successful in some cases, acquired and inherent resistance to these therapeutics remain a treatment hurdle. Oncolytic viruses (OVs) specifically target and lyse cancer cells while leaving normal cells unharmed. One such OV, VSVΔ51, replicates in interferon (IFN) defective cells, a characteristic of approximately 70% of tumours. We hypothesized that the combination of HER2 targeting therapies with VSVΔ51 could improve therapeutic efficacy. We found that HER2 overexpression was associated with increased virus sensitivity and that modulation of HER2 signaling through a subset of activating ligands and inhibitory drugs could influence infection. We further established that the HER2 monoclonal antibodies trastuzumab and pertuzumab mediate an anti-viral effect on VSVΔ51 spread. Finally, we demonstrate that conjugation of a microtubule targeting agent to trastuzumab can overcome the induced anti-viral state and enhance VSVΔ51 spread specifically in cancer cells. Overall, this work highlights the importance of HER2 signaling and activation on VSVΔ51 spread and shows that conjugation of microtubule destabilizing agents to monoclonal antibodies can enhance VSVΔ51 efficacy.
Placing arbuscular mycorrhizal fungi on the risk assessment test battery of plant protection products (PPPs)
Creators: name: Mallmann, Gilvani Carla
name: Pieper, Silvia
name: Sousa, Jose Paulo
name: Sundh, Ingvar
Publisher: name: My University
Year: 2018
Subjects: Referenzmaterial

description: Arbuscular mycorrhizal fungi (AMF) are mutualistic symbionts considered a key group in soil systems involved in the provision of several ecosystem services. Recently they have been listed by EFSA as organisms to be included in the test battery for the risk assessment of plant protection product (PPPs). This study aimed to contribute to improve the ISO Protocol (ISO 10832: 2009) by assessing the feasibility of using other AMF species under different test conditions. Overall, results showed that AMF species Gigaspora albida and Rhizophagus clarus (selected out of five AMF species) are suitable to be used in spore germination tests using the ISO protocol (14 days incubation with sand or artificial soil as substrate) to test PPPs. However, several modifications to the protocol were made in order to accommodate the use of the tested isolates, namely the incubation temperature (28â€ ˚C instead of 24â€ ˚C) and the change of reference substance (boric acid instead of cadmium nitrate). The need for these changes, plus the results obtained with the three fungicides tested (chlorothalonil, mancozeb and metalaxyl-M) and comparisons made with literature on the relevance of the origin of AMF isolates in dictating the adequate test conditions, emphasize the importance of adjusting test conditions (AMF species/isolates and test temperature) when assessing effects for prospective risk assessment targeting different climatic zones. So, further studies should be conducted with different AMF species and isolates from different climatic regions, in order to better define which species/isolate and test conditions should be used to assess effects of a particular PPP targeting a given climatic zone. © Springer Science+Business Media, LLC, part of Springer Nature 2018
Long-term variations in the pulse emission from PSR J0737-3039B
Creators: name: Burgay, M.
name: Possenti, A.
name: Manchester, Richard N.
name: Kramer, Michael
name: McLaughlin, M. A.
name: Lorimer, D. R.
name: Stairs, I. H.
name: Joshi, B. C.
name: Lyne, Andrew G.
name: Camilo, F.
name: D'Amico, N.
name: Freire, P. C. C.
name: Sarkissian, John M.
name: Hotan, Aidan W.
name: Hobbs, G. B.
Publisher: name: Swinburne
Year: 2024

description: Abstract not available.
Subjective logic reasoning: an urn model intuition and application to connected automated driving
Creators: name: Müller, Johannes
name: Buchholz, Michael
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: subjective logic
subject: small sample reasoning
subject: connected automated driving
subject: motion planning
subject: DDC 600 / Technology (Applied sciences)
subject: Automated vehicles
subject: Autonomes Fahrzeug

description: Subjective Logic (SL) is a powerful extend of classical probability theory that can handle small sample sizes and, with that, the resulting statistical uncertainty. However, SL is a quite abstract theory and has found limited attention in the field of automation so far. In this work, we present a new urn model intuition to SL that connects SL with the Pólya urn scheme. The application of SL-based reliability estimation in automation is demonstrated on two examples from the domain of connected automated driving: first to assess external information for motion planning on-board the vehicle and second to rate connected vehicles as agents within a large-scale multi-agent system.
Elderly Fall Detection with an Accelerometer Using Lightweight Neural Networks
Creators: name: Wang, Gaojing
name: Li, Qingquan
name: Wang, Lei
name: Zhang, Yuanshi
name: Liu, Zheng (Professor Of Engineering)
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Falls have been one of the main threats to people’s health, especially for the elderly. Detecting falls in time can prevent the long lying time, which is extremely fatal. This paper intends to show the efficacy of detecting falls using a wearable accelerometer. In the past decade, the fall detection problem has been extensively studied. However, since the hardware resources of wearable devices are limited, designing highly accurate embeddable models with feasible computational cost remains an open research problem. In this paper, different types of shallow and lightweight neural networks, including supervised and unsupervised models are explored to improve the fall detection results. Experiment results on a large open dataset show that the lightweight neural networks proposed have obtained much better results than machine learning methods used in previous work. Moreover, the storage and computation requirements of these lightweight models are only a few hundredths of deep neural networks in literature. In tested lightweight neural networks, the best one is proved to be the supervised convolutional neural network (CNN) that can achieve an accuracy beyond 99.9% with only 441 parameters. Its storage and computation requirements are only 1.2 KB and 0.008 MFLOPs, which make it more suitable to be implemented in wearable devices with restricted memory size and computation power.
Three-dimensional object recognition using pseudo-random color-encoded structured light.
Creators: name: Sakr, Ziad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Electronics and Electrical.

description: 3D surface detection and measurement is one of the primary tasks involved in machine vision. Visual sensing of 3D position parameters can be done passively or actively. A method for 3D surface detection and measurement using a projected grid of light is presented. A novel technique using color projected grids is also explained for the detection and extraction of 3D objects in any colored environment. The "point identification" problem is solved using colored pseudo-random multi-valued sequence encoding. A new technique of finding grid line edges instead of its skeleton is also proved to increase the resolution of the extracted object and obtain additional information on its depth from the camera.
Aberrant chloride transport contributes to anoxic injury in central myelinated axons
Creators: name: Malek, Sameh A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Neuroscience.
subject: Health Sciences, Pathology.

description: Rundown of ionic gradients is a central feature of white matter anoxic injury. However little is known about the contribution of anions such as Cl -. Previous studies have shown that Na+-blockade during anoxia was in adequate in preserving K+-loss. We hypothesized that run down of the K+-gradient during anoxia/Na+-channel inhibition proceeds in conjunction with an anion and more specifically Cl -. We used the in vitro rat optic nerve to study the role of aberrant Cl- transport in anoxia/ischemia. After 30 min of anoxia (NaN3 2mM), axonal membrane potential (V m) decreased to 42 +/- 11% of control, and to 73 +/- 11% in the presence of TTX (1 muM). TTX + DIDS 500muM (a broad spectrum anion transport blocker) abolished anoxic depolarization (95 +/- 8%). Inhibition of the K-Cl cotransporter (KCC) (furosemide 100muM) together with TTX was also more effective than TTX alone (84 +/- 14%). Compound action potential (CAP) area recovered to 26 +/- 6% of control after 1 h anoxia. KCC blockade (furosemide 10muM) improved outcome (40 +/- 4%) and TTX (100nM) was even more effective (74 +/- 12%). In contrast, the Cl- channel blocker niflumic acid (50 muM) worsened injury (6 +/- 1%). Co-application of TTX (100 nM) + furosemide (10 muM) was more effective than either agent alone (91 +/- 9%). Furosemide was also very effective at normalizing the shape of the CAPs. The KCC3a isoform was localized to astrocytes. KCC3 and weaker KCC3a was detected in myelin of larger axons. KCC2 was seen in oligodendrocytes and within axon cylinders. Cl- gradients contribute to resting optic nerve membrane potential, and transporter and channel-mediated Cl- fluxes of during anoxia contribute to injury, possibly due cellular volume changes and disruption of axo-glial integrity, leading to propagation failure and distortion of fiber conduction velocities.
Unravelling information and crocheting meaning: designing complex information for museum audiences
Creators: name: Kocsis, Anita
Publisher: name: Swinburne
Year: 2024

description: This paper discusses the designer’s role in presenting scientific knowledge to museum audiences using the Universe in a Virtual Room: Realising Einstein’s Universe, a stereoscopic 3D animation project at the Museum of Victoria, Australia, as a case study. The exhibition’s development by an interdisciplinary team shows knowledge differences between scientists, designers and audiences to be a fundamental problem for those philosophies of user-centred design that argue that the messages that resonate with audiences should be the basis for design. Other accounts of design see visualisation as more than the simple reproduction of content in the service of audiences, considering it to involve important dimensions of conceptualization on the part of the designer. Hence the questions: What is the scope for user-centred design when neither designer nor audience has sufficient grounding to master scientific knowledge? Can design processes and designers’ distance from science bring new perspectives to science-based information?
Entscheidungsprozesse zur Anpassung an den Klimawandel in Kommunen
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: Anpassung an den Klimawandel
subject: Klimalotse
subject: klimafolgenmanagement
subject: Kommunen
subject: Städte
subject: Gemeinde
subject: Stadtplanung
subject: Kommunaler Klimaschutz
subject: Klima | Energie
subject: Climate | Energy

description: Die vorliegende Untersuchung bildet die wissenschaftliche Grundlage für die Weiterentwicklung des Klimalotsen, einem online-Leitfaden zur Unterstützung von Organisationen bei derAnpassung an den Klimawandel in Deutschland. Zentrale Bausteine des Berichts sind eine Literaturauswertung und eine empirische Untersuchung zu Anpassungsprozessen in Kommunen und kommunalen Einrich-tungen. Der Fokus der Analyse liegt dabei auf den Anstößen und Hindernissen zur Auseinanderset-zung mit der Thematik sowie auf den verschiedenen kommunalen Ansätzen zur Umsetzung von An-passungsmaßnahmen. Die Untersuchungen zeigen, dass unter anderem die eigene Betroffenheit durch Extremwetterereignisse, Teilnahme an Forschungsprojekten und Förderprogrammen sowie passende Schnittstellen mit demKlimaschutzhäufige Einstiegspunkte zur Auseinandersetzung mitKlimafolgenin Kommunen darstellen.
Quelle: www.umweltbundesamt.de

description: Die vorliegende Untersuchung bildet die wissenschaftliche Grundlage für die Weiterentwicklung des Klimalotsen, einem online-Leitfaden zur Unterstützung von Organisationen bei der ⁠Anpassung an den Klimawandel⁠ in Deutschland. Zentrale Bausteine des Berichts sind eine Literaturauswertung und eine empirische Untersuchung zu Anpassungsprozessen in Kommunen und kommunalen Einrich-tungen. Der Fokus der Analyse liegt dabei auf den Anstößen und Hindernissen zur Auseinanderset-zung mit der Thematik sowie auf den verschiedenen kommunalen Ansätzen zur Umsetzung von An-passungsmaßnahmen. Die Untersuchungen zeigen, dass unter anderem die eigene Betroffenheit durch Extremwetterereignisse, Teilnahme an Forschungsprojekten und Förderprogrammen sowie passende Schnittstellen mit dem ⁠Klimaschutz⁠ häufige Einstiegspunkte zur Auseinandersetzung mit ⁠Klimafolgen⁠ in Kommunen darstellen.
Finding violated cut constraints for the STSP using a decomposition approach
Creators: name: Benoit, Genevieve
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Computer Science.

description: The Symmetric Travelling Salesman Problem (STSP) is to find a minimum cost Hainiltonian cycle in the weighted complete graph on n nodes. A well known relaxation (of this problem is the Subtour Elimination Problem (SEP) which provides very good lower bounds for the STSP. In this thesis, we develop a new parallel cutting plane approach for solving the SEP. In this approach, many violated cuts are found at each stage by decomposing the current solution into a set of nicely structured points, and then searching for violations in these points in parallel by using an algorithm which exploits this nice structure. Many ideas presented in this thesis could be adapted to other separation problems in combinatorial optimization. We also discuss several enhancements and heuristics which help speed up our implementation of this new parallel cutting plane framework for solving the SEP. We test our implementation and provide results that we believe demonstrate the usefulness of this new parallel algorithm for finding violated cut constraints each stage of the cutting plane process.
Optical tuning of three-dimensional photonic crystal fabricated by femtosecond direct writing
Creators: name: McPhail, Dennis
name: Straub, Martin
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: In this letter, we report on an optically tunable three-dimensional photonic crystal that exhibits main gaps in the 3–4 µm range. The photonic crystal is manufactured via a femtosecond direct writing technique. Optical tuning is achieved by a luminary polling technique with a low-power polarized laser beam. The refractive index variation resulting from liquid-crystal rotation causes a shift in the photonic band gap of up to 65 nm with an extinction of transmission of up to 70% in the stacking direction. Unlike other liquid-crystal tuning techniques where a pregenerated structure is infiltrated, this optical tuning method is a one-step process that allows arbitrary structures to be written into a solid liquid-crystal-polymer composite and leads to a high dielectric contrast.
Design and implementation of a broadband multimedia TeleLearning system.
Creators: name: Wang, Ruiping.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Engineering, Electronics and Electrical.

description: The advance of the networking and the multimedia technologies are making possible a wide range of interactive applications and services to be built which may eventually change the way that people live. TeleLearning is one prospective area among them which has obtained lots of attentions from both the educators and the researchers. In this thesis we discuss a Multimedia Interactive TeleLearning System under development in the Multimedia Information Research Laboratory at the University of Ottawa. The system aims at providing a seamlessly integrated environment for TeleLearning using the latest telecommunication and multimedia information processing technologies. It provides a new type of learning service--Course On Demand, which makes learning more accessible, more flexible, and with more proper help. The system basically consists of a media production center, a courseware author site, a courseware database, a courseware user site, and an on-line facilitator site. All these components are distributed over an ATM network and work together to offer a multimedia interactive courseware service. An MHEG-based model is exploited as the system architecture to achieve the real-time, reusable information interchange through heterogeneous platforms. The system architecture, courseware-processing strategies, courseware authoring issues. as well as the implementation of the first prototype are presented in this thesis.
Stress, subjective appraisals and anticipation in the context of breast cancer screening.
Creators: name: Sweet, Lisa.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Women's Studies.

description: The study of stress related to real-life potential future events is sparse. Evidence suggests that future events can be meaningfully appraised and generate consequential levels of psychological stress as they are anticipated. The goals of this study were to investigate changes in stress and appraisals over time in a prospective way and to test a novel formulation of anticipation, within the context of a true stressor. Participants were women undergoing routine breast cancer screening as part of a provincially funded program. From the original sample (n = 606), women were divided into normal (negative, n = 541) and abnormal (false-positive, n = 65) groups and completed measures of stress and cognitive appraisals at four critical time points: (1) prior to the screening, (2) one day after the screening, (3) 20 days after screening and (4) at a three-months post-screen follow-up. A comparison group (n = 119) of women not currently undergoing screening was also included in the study. Anovas revealed a significant decrease in stress for negatives and false-positives reported more stress than negatives at Time 2. As for appraisals, manovas showed that for negatives perceived impact and perceived uncertainty decreased while perceived mastery increased throughout the process. For false-positives, there was an increase in perceived impact from Time 1 to Time 2, then a decrease from Time 3 to Time 4. False-positives reported more perceived impact and perceived uncertainty than negatives at Time 2 and Time 3. In terms of anticipation, we showed that women seemed to appraise the potential event more negatively at the outset and then experienced a decrease in stress. Additional analyses also revealed that the Clinical Breast Exam results can have a profound impact on women's experience of screening. The research and clinical implications of these findings, as well as the strengths and limitations of the present study are reviewed in the discussion.
Queering Dixie: The challenging of social norms in contemporary gay fiction
Creators: name: Evans, Richard
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Literature, American.

description: This thesis inquires into how three contemporary gay and lesbian Southern authors under the age of 35 challenge and question the established notions of gender, class, sexuality, and religion in the American South. The three authors under consideration are Christopher Rice ( A Density of Souls), Poppy Z. Brite (Drawing Blood), and Julia Watts (Finding H. F.). By examining the works of a gay man from New Orleans (an urban area), a bisexual woman originally from Georgia now living in New Orleans (urban/rural spheres), and a lesbian from small-town Kentucky (rural space), respectively, the notion of the security and power of an established urban "queer" community reaching out to positively influence the rural space is explored. The traditional expectation within gay and lesbian writing of the necessity to flee the repressive rural space for the liberation of the urban Mecca is thus both explored and challenged by these three young authors.
title: An Evaluation of Care Coordination in Reducing Depression Symptoms and Emergency Room Visits
Creators: name: Sumpter, Stacy
Publisher: name: University of Nevada, Las Vegas
Year: 2021

description: Background: Individuals living with multiple chronic conditions (MCC) account for 26% of the population; however, they consume 84% of healthcare resources, are three times more likely to have depression than healthy individuals, and have increase emergency room (ER) visits and healthcare resource use. This population requires coordinated health care to reduce unnecessary spending and the misappropriation of healthcare resources. The purpose of this project was to evaluate the efficacy of care coordination (CC) and the support system it provides in lowering depression symptoms and ER visit frequency as a viable measure to reduce overall healthcare costs.

Methods: The healthcare providers, care coordinators, and office staff were informed of the project and provided weekly briefings to acknowledge milestones and answer questions. The healthcare provider identified CC candidates and referred them to the care coordinator. The participant completed a PHQ-9 tool, and the results were recorded in the patient's medical record and given to the healthcare provider and the student investigator. Participants began using CC services, and care coordinators developed care plans approved by the PCP. CC services supported care transition, education services, and healthcare resource coordination between PCPs and specialists; promoted self-care and treatment adherence; and streamlined access to the PCP through telephone and face-to-face communication. The coordinator contacted the patient every two weeks if no contact had occurred within that time. Participants were encouraged to call their care coordinator with any health changes, medication or treatment questions, or health-related concerns. The care coordinator approached the PCP with any patient concerns or problems identified, which were promptly addressed. The number of contacts between care coordinators and each patient ranged from 7 to 44 during this study. Patients completed a follow-up PHQ-9 three months after initiating CC services. These were recorded in the medical record and given to the PCP and student investigator. The billing manager populated reports from the CMS claims data on the ER visit frequency for the three months before and during enrollment in CC services.

Results: The paired t-test showed a statistically significant reduction in PHQ-9 scores (p= 0.008) and ER visit frequency (p= 0.005) with the intervention.

Conclusion: The project concluded that CC services and their support statistically reduced depression symptoms, evidenced by PHQ-9 scores and ER visit frequency. These positive, quantifiable results may provide evidence-based outcomes to support the benefits of incorporating CC into overall patient care and influence private health insurance companies to reimburse CC services.
Adoption of improved processing technology among African locust bean processors in south-west, Nigeria
Creators: name: Kolapo, A.
name: Omopariola, O.E.
name: Adeoye, A.O.
name: Kolapo, A.J.
name: Kolapo, A.
name: Omopariola, O.E.
name: Adeoye, A.O.
name: Kolapo, A.J.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agricultural and Food Policy
subject: African locust bean
subject: Improved processing technology
subject: Adoption
subject: Processors
subject: South-West

description: The paper investigated the effect of socio-economic and institutional factors on the adoption of improved locust bean processing technology in South-West, Nigeria. Specifically, the study described the socio-economic characteristics of the locust bean processors, examines the level of awareness and adoption of the improved locust bean processing technology in the study area and determines the effect of socio-economic and institutional factors on the adoption and intensity of use of improved locust bean processing technology in the study area. A multi-stage sampling procedure was used to select 360 respondents used for the study. The data were analyzed using descriptive statistics and the Cragg’s (double-hurdle) model. The result of the study showed that majority (84%) of the locust bean processors were female with an average age of 48 (±11.36) years. Majority (97%) of the respondents were married with an average household size of 8.25 (±4.32) persons. The result showed that 44.2% were aware while 55.8% were not aware of the technology in the study area. The results from the Cragg’s double hurdle model show that in the first hurdle, age, experience, access to credit and awareness positively influenced the decision to adopt the improved locust bean processing technology while in the second hurdle, education and income positively influenced the intensity of the use of the improved locust bean processing technology. It is therefore recommended that Relevant stakeholders, agencies and government should made available credit facilities which will enable the locust bean processors acquired the technology in no distant time.
Experiences of university women at risk for developing eating disorders
Creators: name: Mathias, Michelle D
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Women's Studies.
subject: Psychology, Clinical.

description: Studies within the field of eating disorders often address pathology, prevalence/risk factors, body image, beliefs/perceptions (not specific to body image), treatment programs and psychometry. The main theoretical frameworks may be classified as developmental, sociocultural and perceptual. Most research, however, has been conducted using quantitative methodologies with clinical populations. Of the few qualitative studies (Blok, 2002; Budd, 2002; Pearson, 1998), none of them investigate the experience of being at risk for developing eating disorders. This was the aim of this study, which used a mixed methodology and a health perspective. In phase one, Quantitative questionnaires were administered to university women in order to identify four who were at risk for developing an eating disorder. In the second phase, qualitative interviews, using a phenomenological approach, were then conducted with the four consenting participants in order to appreciate their daily experiences of being at-risk. Gathered data was then analysed using two strategies. The first entailed regrouping data according to Integrator Themes. Results reveal a deeper, richer understanding of the experiences, as they were revealed phenomenologically. The second analysis strategy used the Wellness Model (Donatelle, Davis, Munroe, & Munroe, 2001), which describes health as having six dimensions: physical/physiological, psychological, social, environmental, intellectual and spiritual. Results of this analysis reveal that all six dimensions are impacted when a woman is at-risk of developing an eating disorder. While her specific experiences may be unique, one from the other, all aspects of her life are affected. Discussion emphasises the importance of qualitative methodologies and the use of a health perspective in this domain of study.
Assessing the role of collective efficacy beliefs during participative occupational health interventions
Creators: name: Kuchenbaur, Marco
name: Peter, Richard
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: participative intervention
subject: collective efficacy beliefs
subject: process evaluation
subject: questionnaire
subject: DDC 610 / Medicine & health
subject: Occupational health
subject: Surveys and questionnaires
subject: Arbeitsmedizin
subject: Umfrage
subject: Fragebogen

description: Background: For group-based participatory interventions in the context of occupational health, no questionnaires exist to assess the participants' active engagement in the interventions. On the basis of the construct of collective efficacy beliefs, this study has developed a questionnaire with which the group-related efficacy beliefs can be assessed as a precondition for participants actively engaging in participative interventions. Methods: Participants were drawn from a two-arm cluster-randomized intervention study to fill out the questionnaire. A Factor analysis and an initial psychometric calibration were performed. In a second step, the group-related properties of the questionnaire were validated using a Multilevel analysis. Results: The factorial structure of the questionnaire is consistent with the theory of efficacy beliefs according to A. Bandura. Furthermore, the collective efficacy expectations of the interventions' participants are lowered in the absence of appreciation and support in the psychosocial environment of the worksite. Conclusions: Assessing participant's quality of interventional activity in participatory interventions by collective efficacy can be valuable in understanding the amount of interventional activity. In addition, it is recommended to consider the influence of the worksite's psychosocial environment on collective efficacy beliefs when implementing participatory interventions. Clinical Trial Registration: Registration trial DRKS00021138 on the German Registry of Clinical Studies (DRKS), retrospectively registered on 25 March, 2020.