cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Heavy and light flavor jet quenching at RHIC and LHC energies
Creators: name: Cao, Shanshan
name: Luo, Tan
name: Qin, Guang-You
name: Wang, Xin-Nian
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The Linear Boltzmann Transport (LBT) model coupled to hydrodynamical background is extended to include transport of both light partons and heavy quarks through the quark-gluon plasma (QGP) in high-energy heavy-ion collisions. The LBT model includes both elastic and inelastic medium-interaction of both primary jet shower partons and thermal recoil partons within perturbative QCD (pQCD). It is shown to simultaneously describe the experimental data on heavy and light flavor hadron suppression in high-energy heavy-ion collisions for different centralities at RHIC and LHC energies. More detailed investigations within the LBT model illustrate the importance of both initial parton spectra and the shapes of fragmentation functions on the difference between the nuclear modifications of light and heavy flavor hadrons. The dependence of the jet quenching parameter $\hat{q}$ on medium temperature and jet flavor is quantitatively extracted.
description: 6 pages, 6 figures
title: Bericht über die Kampagnen der Jahre 2004/05 im Heiligtum des Vaelicus in Postoloboso (Candeleda, Prov. Ávila)
title: Bericht über die Kampagnen der Jahre 2004/05 im Heiligtum des Vaelicus in Postoloboso (Candeleda, Prov. Ávila)
titleType: Subtitle
Creators: name: Schattner, Thomas G.
name: Mariné Isidro, Maria
name: Koch, Michael
name: Geldmacher, Nicola
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Postoloboso
subject: Vaelicus
subject: Postoloboso
subject: Vaelicus
subject: Postoloboso
subject: Vaelicus

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
title: Monte do Facho. Bericht über die Ausgrabungen im Heiligtum des Berobreus
title: Monte do Facho. Bericht über die Ausgrabungen im Heiligtum des Berobreus
titleType: Subtitle
Creators: name: Schattner, Thomas G.
name: Suárez Otero, José
name: Koch, Michael
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Monte do Facho
subject: Heiligtum von Berobreo
subject: Monte do Facho
subject: sanctuary of Berobreo
subject: Monte do Facho
subject: santuario de Berobreo

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations
Creators: name: Elwan, Alaa
name: Sakr, Helmy
name: El-Helby, Abdel-Ghany A.
name: El-morsy, Ahmed
name: Abdelgawad, Mohamed A.
name: Ghoneim, Mohammed M.
name: El-Sherbiny, Mohamed
name: El-Adl, Khaled
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer
Virology

description: Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c and 7b exhibited the highest anticancer activities. Their activities were higher than that of doxorubicin. Molecular docking studies showed that the HBA present in the chromophore, the substituted distal phenyl moiety and the extended linkers enable our derivatives to act as DNA binders. Also, the pyrazoline moiety formed six H-bonds and improved affinities with DNA active site. Finally, 7e, 7c and 7b exhibited the highest DNA affinities and act as traditional intercalators of DNA. The most active derivatives 7e, 7c, 7b, 7g and 6e were subjected to evaluate their Topo II inhibition and DNA binding actions. Derivative 7e exhibited the highest binding affinity. It intercalates DNA at IC50 = 29.06 µM. Moreover, compound 7e potently intercalates DNA at an IC50 value of 31.24 µM. Finally, compound 7e demonstrated the most potent Topo II inhibitor at a value of 0.890 µM. Compound 7c exhibited an equipotent IC50 value (0.940 µM) to that of doxorubicin. Furthermore, derivatives 7b, 7c, 7e and 7g displayed a high ADMET profile.
Modeling and Simulation of Database Interactions
Creators: name: Melzer, Sylvia
name: Eichmann, Oliver C.
name: Hongxu Wang
name: God, Ralf
Publisher: name: Universität Hamburg
Year: 2021
Subjects: SysML
SQL
database interaction
modeling
simulation
opaque behavior
opaque action
small and medium-sized enterprises
SME
Cameo Systems Modeler
SysML Toolbox
Data Linking
CSMC
UWA

description: In this paper and presentation, we present a model-based best practice approach for the digitization and early validation of

enterprise processes that allows the integration of real databases into SysML simulations.

The paper was submitted for review and accepted for the Tag des Systems Engineering 2021 - digital.

 
description: This research work was supported by the LuFo V-3 project "Industrie 4.0-Fähigkeit der KMU bei der Herstellung, Lieferung und der Zulassung von Flugzeugausrüstung (KMUDigital)", funded by the Federal Ministry for Economic Affairs and Energy based on the decision by the German Bundestag.
title: Munigua – der Anfang vom Ende. Die Aussage der Bronzeskulpturen und anderer Funde
title: Munigua – der Anfang vom Ende. Die Aussage der Bronzeskulpturen und anderer Funde
titleType: Subtitle
Creators: name: Krug, Antje
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Munigua
subject: Bronzeskulpturen
subject: Munigua
subject: bronze sculpture
subject: Mulva
subject: escultura en bronce

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
The Berezin form on symmetric $R$-spaces and reflection positivity
Creators: name: Möllers, Jan
name: Ólafsson, Gestur
name: Ørsted, Bent
Publisher: name: arXiv
Year: 2017
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 22E46

description: For a symmetric $R$-space $K/L=G/P$ the standard intertwining operators provide a canonical $G$-invariant pairing between sections of line bundles over $G/P$ and its opposite $G/\overline{P}$. Twisting this pairing with an involution of $G$ which defines a non-compactly causal symmetric space $G/H$ we obtain an $H$-invariant form on sections of line bundles over $G/P$. Restricting to the open $H$-orbits in $G/P$ constructs the Berezin forms studied previously by G. van Dijk, S. C. Hille and V. F. Molchanov. We determine for which $H$-orbits in $G/P$ and for which line bundles the Berezin form is positive semidefinite, and in this case identify the corresponding representations of the dual group $G^c$ as unitary highest weight representations. We further relate this procedure of passing from representations of $G$ to representations of $G^c$ to reflection positivity.
description: 42 pages
Line and Point Defects in Nonlinear Anisotropic Solids
Creators: name: Ashkan Golgoon
name: Yavari, Arash
Publisher: name: figshare
Year: 2018
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Mechanics
subject: 91308 Solid Mechanics
subject: 10207 Theoretical and Applied Mechanics
subject: FOS: Mathematics

description: In this paper, we present some analytical solutions for the stress fields of nonlinear anisotropic solids with distributed line and point defects. In particular, we determine the stress fields of i) a parallel cylindrically-symmetric distribution of screw dislocations in infinite orthotropic and monoclinic media, ii) a cylindrically-symmetric distribution of parallel wedge disclinations in an infinite orthotropic medium, iii) a distribution of edge dislocations in an orthotropic medium, and iv) a spherically-symmetric distribution of point defects in a transversely isotropic spherical ball.
Finite Eigenstrains in Nonlinear Elastic Solid Wedges
Creators: name: Ashkan Golgoon
name: Souhayl Sadik
name: Yavari, Arash
Publisher: name: figshare
Year: 2018
Subjects: subject: Geometry
subject: 10207 Theoretical and Applied Mechanics
subject: FOS: Mathematics
subject: 10112 Topology

description: Eigenstrains in nonlinear solids are created due to anelastic effects such as non-uniform temperature distributions, growth, remodeling, and defects. Eigenstrains understanding is indispensable, as they can generate residual stresses and strongly affect the overall response of solids. Here, we study the residual stress and deformation fields of an incompressible isotropic infinite wedge with a circumferentially-symmetric distribution of finite eigenstrains. We construct a material manifold, whose Riemannian metric explicitly depends on the eigenstrain distribution, thereby we turn the problem into a classical nonlinear elasticity problem, where we find an embedding of the Riemannian material manifold into the ambient Euclidean space. In particular, we find exact solutions for the residual stress and deformation fields of a neo-Hookean wedge having a symmetric inclusion with finite radial and circumferential eigenstrains. Moreover, we numerically solve a similar problem when a symmetric Mooney-Rivlin inhomogeneity with finite eigenstrains is placed in a neo-Hookean wedge. Generalization of the eigenstrain problem to other geometries are also discussed.
Additional file 1 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 1: Figure S1. AD and control brains have similar amounts of soluble protein. Amido black stained Western blot of control and AD cortex RIPA-soluble (supernatant) fractions. Each lane is a cortical sample from one individual, presented in the same order as the cases in Table S1 (1–16). The ratios reflecting the total protein in the various quadrants are presented along with tubulin. The 51 kDa protein (tubulin) was excluded from the analysis of each quadrant. P values are given. Data are presented as mean ± SEM (n = 8/group).
Design, synthesis and biological evaluation of novel diosgenin–benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells
Creators: name: Zhang, Jinling
name: Wang, Wenbao
name: Tian, Yanzhao
name: Ma, Liwei
name: Zhou, Lin
name: Sun, Hao
name: Ma, Yukun
name: Hou, Huiling
name: Wang, Xiaoli
name: Ye, Jin
name: Wang, Xiaobo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: To discover new lead compounds with anti-tumour activities, in the present study, natural diosgenin was hybridised with the reported benzoic acid mustard pharmacophore. The in vitro cytotoxicity of the resulting newly synthesised hybrids (8–10, 14a–14f, and 15a–15f) was then evaluated in three tumour cells (HepG2, MCF-7, and HeLa) as well as normal GES-1 cells. Among them, 14f possessed the most potential anti-proliferative activity against HepG2 cells, with an IC50 value of 2.26 µM, which was 14.4-fold higher than that of diosgenin (IC50 = 32.63 µM). Furthermore, it showed weak cytotoxicity against GES-1 cells (IC50 > 100 µM), thus exhibiting good antiproliferative selectivity between normal and tumour cells. Moreover, 14f could induce G0/G1 arrest and apoptosis of HepG2 cells. From a mechanistic perspective, 14f regulated cell cycle-related proteins (CDK2, CDK4, CDK6, cyclin D1 and cyclin E1) as well mitochondrial apoptosis pathway-related proteins (Bax, Bcl-2, caspase 9, and caspase 3). These findings suggested that hybrid 14f serves as a promising anti-hepatoma lead compound that deserves further research.
title: »Corriger la fortune«. Falschspiel in Munigua
title: »Corriger la fortune«. Falschspiel in Munigua
titleType: Subtitle
Creators: name: Krug, Antje
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Munigua
subject: Munigua
subject: Mulva

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
title: Der Kanal in der Thermengasse. Ein Beitrag zur Verfallsgeschichte der Bauten auf dem Stadthügel von Munigua
title: Der Kanal in der Thermengasse. Ein Beitrag zur Verfallsgeschichte der Bauten auf dem Stadthügel von Munigua
titleType: Subtitle
Creators: name: Schattner, Thomas G.
name: Basas Fauré, Carlos
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Munigua
subject: Munigua
subject: Mulva

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
Finite_Eigenstrains_in_Nonlinear_Elastic.pdf
Creators: name: Ashkan Golgoon
name: Souhayl Sadik
name: Yavari, Arash
Publisher: name: figshare
Year: 2018
Subjects: subject: Geometry
subject: 10207 Theoretical and Applied Mechanics
subject: FOS: Mathematics
subject: 10112 Topology

description: Eigenstrains in nonlinear solids are created due to anelastic effects such as non-uniform temperature distributions,growth, remodeling, and defects. Eigenstrains understanding is indispensable, as they can generate residual stresses andstrongly affect the overall response of solids. Here, we study the residual stress and deformation fields of an incompressibleisotropic infinite wedge with a circumferentially-symmetric distribution of finite eigenstrains. We construct a material manifold,whose Riemannian metric explicitly depends on the eigenstrain distribution, thereby we turn the problem into a classicalnonlinear elasticity problem, where we find an embedding of the Riemannian material manifold into the ambient Euclideanspace. In particular, we find exact solutions for the residual stress and deformation fields of a neo-Hookean wedge having asymmetric inclusion with finite radial and circumferential eigenstrains. Moreover, we numerically solve a similar problem whena symmetric Mooney-Rivlin inhomogeneity with finite eigenstrains is placed in a neo-Hookean wedge. Generalization of theeigenstrain problem to other geometries are also discussed.
title: Reflexiones sobre el relieve castreño de Formigueiro (Amoeiro, Ourense)
title: Reflexiones sobre el relieve castreño de Formigueiro (Amoeiro, Ourense)
titleType: Subtitle
Creators: name: Castro Pérez, Ladislao
name: Reboreda Morillo, Susana
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Zusammenfassung folgt.
Radial anisotropy in omega Cen limiting the room for an intermediate-mass black hole
Creators: name: Zocchi, Alice
name: Gieles, Mark
name: Hénault-Brunet, Vincent
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Finding an intermediate-mass black hole (IMBH) in a globular cluster (or proving its absence) would provide valuable insights into our understanding of galaxy formation and evolution. However, it is challenging to identify a unique signature of an IMBH that cannot be accounted for by other processes. Observational claims of IMBH detection are indeed often based on analyses of the kinematics of stars in the cluster core, the most common signature being a rise in the velocity dispersion profile towards the centre of the system. Unfortunately, this IMBH signal is degenerate with the presence of radially-biased pressure anisotropy in the globular cluster. To explore the role of anisotropy in shaping the observational kinematics of clusters, we analyse the case of omega Cen by comparing the observed profiles to those calculated from the family of LIMEPY models, that account for the presence of anisotropy in the system in a physically motivated way. The best-fit radially anisotropic models reproduce the observational profiles well, and describe the central kinematics as derived from Hubble Space Telescope proper motions without the need for an IMBH.
description: 14 pages, 7 figures. Accepted for publication in MNRAS
Discovery of a new class of triazole based inhibitors of acetyl transferase KAT2A
Creators: name: Pacifico, Roberta
name: Del Gaudio, Nunzio
name: Bove, Guglielmo
name: Altucci, Lucia
name: Siragusa, Lydia
name: Cruciani, Gabriele
name: Ruvo, Menotti
name: Bellavita, Rosa
name: Grieco, Paolo
name: Adamo, Mauro F. A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and validated for drug discovery and development. This study determined a number of potential structure target dyads of which N-pyridinium-4-carboxylic-5-alkyl triazole displayed the highest score specificity towards KAT2A. Binding affinity tests of abovementioned triazole and related analogs towards KAT2A confirmed the predictions of the in-silico assay. Finally, we have run in vitro inhibition assays of selected triazoles towards KAT2A; the ensemble of binding and inhibition assays delivered pyridyl-triazoles carboxylates as the prototype of a new class of inhibitors of KAT2A.
Unveiling the Greek phytodiversity: Dimitrios Zaganiaris and his legacy in TAU Herbarium
Creators: name: Karousou, Regina
name: Giourieva, Victoria
name: Choreftakis, Michalis
name: Siaraka, Konstantina
name: Hanlidou, Effie
name: Gkelis, Spyros
Publisher: name: Journal of Biological Research - Thessaloniki
Year: 2024
Subjects: TAU Herbarium; historical collections; Dimitrios Zaganiaris; Greek phytodiversity

description: Dimitrios Zaganiaris, a distinguished botanist who worked and published between 1932 and 1940, remains a relatively enigmatic figure within the botanical history of Greece, with scant information available about his life and work. His collections, exclusively kept in the Thessaloniki Aristotle University Herbarium (TAU Herbarium), remained neglected for several decades and have never been studied systematically as a whole. In this work his full biography, together with a list of 1695 specimens, cited in Zaganiaris “The flora of Mani” and “Herbarium Macedonicum” or hitherto unpublished, are presented for the first time. This material includes valuable data that are anticipated to shed new light to the Greek phytodiversity.
description: Journal of Biological Research - Thessaloniki, Vol 31 (2024)
Additional file 2 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 2: Figure S2. The MCI brain has increased amounts of insoluble protein. Amido black stained Western blot of control and MCI cortex RIPA-insoluble fractions (aggregates). Each lane is a cortical sample from one individual, presented in the same order as the cases in Table S2 (17–36). The ratios reflecting the total protein in the various quadrants are presented along with tubulin. The 51 kDa protein (tubulin) was excluded from the analysis of each quadrant. P values are given. Data are presented as mean ± SEM (n = 10/group).
title: Das tartessische Carmona. Eine Stadt mit Statuen. Zu dem Neufund einer Statuette
title: Das tartessische Carmona. Eine Stadt mit Statuen. Zu dem Neufund einer Statuette
titleType: Subtitle
Creators: name: Belén Deamos, María
name: García Morillo,  María Carmen
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
Development of newly synthesised quinazolinone-based CDK2 inhibitors with potent efficacy against melanoma
Creators: name: Mohammed, Eman R.
name: Elmasry, Ghada F.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: Inhibiting Cyclin-dependent kinase 2 (CDK2) has been established as a therapeutic strategy for the treatment of many cancers. Accordingly, this study aimed at developing a new set of quinazolinone-based derivatives as CDK2 inhibitors. The new compounds were evaluated for their anticancer activity against sixty tumour cell lines. Compounds 5c and 8a showed excellent growth inhibition against the melanoma cell line MDA-MB-435 with GI% of 94.53 and 94.15, respectively. Cell cycle analysis showed that compound 5c led to cell cycle cessation at S phase and G2/M phase revealing that CDK2 could be the plausible biological target. Thus, the most cytotoxic candidates 5c and 8a were evaluated in vitro for their CDK2 inhibitory activity and were able to display significant inhibitory action. The molecular docking study confirmed the obtained results. ADME study predicted that 5c had appropriate drug-likeness properties. These findings highlight a rationale for further development and optimisation of novel CDK2 inhibitors.
A Branch-and-Bound Algorithm for Checkerboard Extraction in Camera-Laser Calibration
Creators: name: Khosravian, Alireza
name: Chin, Tat-Jun
name: Reid, Ian
Publisher: name: arXiv
Year: 2017
Subjects: subject: Robotics (cs.RO)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: We address the problem of camera-to-laser-scanner calibration using a checkerboard and multiple image-laser scan pairs. Distinguishing which laser points measure the checkerboard and which lie on the background is essential to any such system. We formulate the checkerboard extraction as a combinatorial optimization problem with a clear cut objective function. We propose a branch-and-bound technique that deterministically and globally optimizes the objective. Unlike what is available in the literature, the proposed method is not heuristic and does not require assumptions such as constraints on the background or relying on discontinuity of the range measurements to partition the data into line segments. The proposed approach is generic and can be applied to both 3D or 2D laser scanners as well as the cases where multiple checkerboards are present. We demonstrate the effectiveness of the proposed approach by providing numerical simulations as well as experimental results.
description: To appear in IEEE Conference on Robotics and Automation 2017
Design and synthesis of new trimethoxylphenyl-linked combretastatin analogues loaded on diamond nanoparticles as a panel for ameliorated solubility and antiproliferative activity
Creators: name: Zaki, Islam
name: Moustafa, Amal M. Y.
name: Beshay, Botros Y.
name: Masoud, Reham E.
name: Elbastawesy, Mohammed A. I.
name: Abourehab, Mohammed A. S.
name: Zakaria, Mohamed Y.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: A new series of vinyl amide-, imidazolone-, and triazinone-linked combretastatin A-4 analogues have been designed and synthesised. These compounds have been evaluated for their cytotoxic activity against MDA-MB-231 breast cancer cells. The triazinone-linked combretastatin analogues (6 and 12) exhibited the most potent cytotoxic activity, in sub-micromolar concentration compared with combretastatin A-4 as a reference standard. The results of β-tubulin polymerisation inhibition assay appear to correlate well with the ability to inhibit β-tubulin polymerisation. Additionally, these compounds were subjected to biological assays relating to cell cycle aspects and apoptosis induction. In addition, the most potent compound 6 was loaded on PEG-PCL modified diamond nanoparticles (PEG-PCL-NDs) and F4 was picked as the optimum formula. F4 exhibited enhanced solubility and release over the drug suspension. In the comparative cytotoxic activity, PEG-PCL modified F4 was capable of diminishing the IC50 by around 2.89 times for nude F4, while by 3.48 times relative to non-formulated compound 6.
phd thesis neuroscience[1].pdf
Creators: name: Bheemaiah, Anil Kumar
Publisher: name: figshare
Year: 2018
Subjects: Neuroscience

description: The efficacy of genetic algorithms in the design of models that model specific and experimental aspects of action potentials in a wide variety of organisms is proven. A specific example of a plant action potential is used to illustrate the use of genetic algorithms in the search for parameters of models. The efficiency of the genetic algorithms as a search method is in the short generation span of the convergence of the algorithm
Driven Brownian particle as a paradigm for a nonequilibrium heat bath: Effective temperature and cyclic work extraction
Creators: name: Wulfert, Robert
name: Oechsle, Michael
name: Speck, Thomas
name: Seifert, Udo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We apply the concept of a frequency-dependent effective temperature based on the fluctuation-dissipation ratio to a driven Brownian particle in a nonequilibrium steady state. Using this system as a thermostat for a weakly coupled harmonic oscillator, the oscillator thermalizes according to a canonical distribution at the respective effective temperature across the entire frequency spectrum. By turning the oscillator from a passive "thermometer" into a heat engine, we realize the cyclic extraction of work from a single thermal reservoir, which is feasible only due to its nonequilibrium nature.
description: Phys. Rev. E (RC), in press
Structure-guided design and optimization of covalent VHL-targeted sulfonyl fluoride PROTACs.
Creators: name: Shah, Rishi R
name: De Vita, Elena
name: Sathyamurthi, Preethi S
name: Conole, Daniel
name: Zhang, Xinyue
name: Fellows, Elliot
name: Dickinson, Eleanor R
name: Fleites, Carlos M
name: Queisser, Markus A
name: Harling, John D
name: Tate, Edward W
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Model organisms
subject: Model organisms
classificationCode: Infectious Disease
subject: Infectious Disease

description: Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have emerged as a therapeutic modality to induce targeted protein degradation (TPD) by harnessing cellular proteolytic degradation machinery. PROTACs which ligand the E3 ligase in a covalent manner have attracted intense interest; however, covalent PROTACs with a broad protein of interest (POI) scope have proven challenging to discover by design. Here, we report the structure-guided design and optimization of Von Hippel-Lindau (VHL) protein-targeted sulfonyl fluorides which covalently bind Ser110 in the HIF1α binding site. We demonstrate that their incorporation in bifunctional degraders induces targeted protein degradation of BRD4 or the androgen receptor without further linker optimization. Our study discloses the first covalent VHL ligands which can be implemented directly in bifunctional degrader design, expanding the substrate scope of covalent E3 ligase PROTACs.
title: El final de la Edad del Bronce entre el Guadiana y el Guadalquivir. Síntesis histórico-arqueológica según las más recientes evidencias
title: El final de la Edad del Bronce entre el Guadiana y el Guadalquivir. Síntesis histórico-arqueológica según las más recientes evidencias
titleType: Subtitle
Creators: name:  Gómez Toscano, Francisco
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Die Forschungen zur Endbronzezeit im Südwesten der Iberischen Halbinsel postulierten eine kaum entwickelte Gesellschaft, eine Voraussetzung, die auf Strukturen der Besiedlung und der Siedlungsplätze gründet. Die archäologische Dokumentation spricht aber gegen das Modell einer vorphönizischen Gesellschaft in dieser Region zwischen den Mündungsgebieten des Guadiana und des Guadalquivirs, wie es von den Hüttensiedlungen nahe gelegt wurde.
A Discrete-Time Attitude Observer on SO(3) for Vision and GPS Fusion
Creators: name: Khosravian, Alireza
name: Chin, Tat-Jun
name: Reid, Ian
name: Mahony, Robert
Publisher: name: arXiv
Year: 2017
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper proposes a discrete-time geometric attitude observer for fusing monocular vision with GPS velocity measurements. The observer takes the relative transformations obtained from processing monocular images with any visual odometry algorithm and fuses them with GPS velocity measurements. The objectives of this sensor fusion are twofold; first to mitigate the inherent drift of the attitude estimates of the visual odometry, and second, to estimate the orientation directly with respect to the North-East-Down frame. A key contribution of the paper is to present a rigorous stability analysis showing that the attitude estimates of the observer converge exponentially to the true attitude and to provide a lower bound for the convergence rate of the observer. Through experimental studies, we demonstrate that the observer effectively compensates for the inherent drift of the pure monocular vision based attitude estimation and is able to recover the North-East-Down orientation even if it is initialized with a very large attitude error.
description: To appear in IEEE Conference on Robotics and Automation 2017
Approximation of Periodic PDE Solutions with Anisotropic Translation Invariant Spaces
Creators: name: Bergmann, Ronny
name: Merkert, Dennis
Publisher: name: arXiv
Year: 2017
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 42B35, 42B37, 65T40, 74B05, 74E30

description: We approximate the quasi-static equation of linear elasticity in translation invariant spaces on the torus. This unifies different FFT-based discretisation methods into a common framework and extends them to anisotropic lattices. We analyse the connection between the discrete solution spaces and demonstrate the numerical benefits. Finite element methods arise as a special case of periodised Box spline translates.
Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells
Creators: name: Liu, Jia
name: Zhu, Xingwang
name: Yu, Liu
name: Mao, Minghuan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Aim:A series of sulphonamide hybrids were designed, synthesised, and identified as potential lysine-specific demethylase 1 (LSD1) inhibitors. Materials and methods: Bladder cancer cell lines were cultured to evaluate the antiproliferative activity. Inhibitory evaluation of sulphonamide hybrids against LSD1 were performed. Conclusion: sulphonamide derivative L8 exhibited the antiproliferative activity against HTB5, HTB3, HT1376, and HTB1 cells with IC50 values of 1.87, 0.18, 0.09, and 0.93 μM, respectively. Compound L8 as a selective and reversible LSD1 inhibitor could inhibit LSD1 with the IC50 value of 60 nM. It effectively inhibited LSD1 by increasing the expression levels of H3K4me1, H3K4me2, and H3K9me2 in HT1376 cells. To the best of our knowledge, this was the first report which showed that sulphonamide–quinoline–dithiocarbamate hybrids potently inhibited LSD1 in bladder cancer cells. Our studies give the potential application of the sulphonamide-based scaffold for developing LSD1 inhibitors to treat bladder cancer. L8 exhibits the antiproliferative activity against bladder cancer cells. L8 is a selective and reversible LSD1 inhibitor. L8 increases the expression levels of H3K4me1, H3K4me2 and H3K9me2.
title: Zur Datierung der ältesten griechischen und phönizischen Importkeramik auf der Iberischen Halbinsel. Bemerkungen zum Beginn der Eisenzeit in Südwesteuropa
title: Zur Datierung der ältesten griechischen und phönizischen Importkeramik auf der Iberischen Halbinsel. Bemerkungen zum Beginn der Eisenzeit in Südwesteuropa
titleType: Subtitle
Creators: name: Brandherm, Dirk
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
title: In Memoriam Pedro de Palol Salellas (1923-2005)
title: In Memoriam Pedro de Palol Salellas (1923-2005)
titleType: Subtitle
Creators: name: Ulbert, Thilo
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Pedro de Palol Salellas (1923-2005)
subject: Pedro de Palol Salellas (1923-2005)

description: Madrider Mitteilungen, Vol. 48 (2007)
description: In Memoriam Pedro de Palol Salellas (1923-2005).
Peculiar double-periodic pulsation in RR Lyrae stars of the OGLE collection. II. Short-period stars with dominant radial fundamental mode
Creators: name: Prudil, Zdenek
name: Smolec, Radoslaw
name: Skarka, Marek
name: Netzel, Henryka
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the discovery of a new group of double-periodic stars in the OGLE Galactic bulge photometry. In 38 stars identified as fundamental mode RR~Lyrae and 4 classified as the first-overtone RR~Lyrae, we detected additional shorter periodicity. Periods of the dominant variability in the newly discovered group are $0.28
description: Accepted for publication in MNRAS
Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
Creators: name: Taghour, Mohammed S.
name: Elkady, Hazem
name: Eldehna, Wagdy M.
name: El-Deeb, Nehal M.
name: Kenawy, Ahmed M.
name: Elkaeed, Eslam B.
name: Alsfouk, Aisha A.
name: Alesawy, Mohamed S.
name: Metwaly, Ahmed M.
name: Eissa, Ibrahim. H.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids with potential activity against VEGFR-2. The cytotoxic effects of the synthesised derivatives against Caco-2, HepG-2, and MDA-MB-231 cell lines were investigated. Compound 12a was found to be the most potent candidate against the investigated cell lines with IC50 values of 2, 10, and 40 µM, respectively. Furthermore, the synthesised derivatives were tested in vitro for their VEGFR-2 inhibitory activity showing strong inhibition. Moreover, an in vitro viability study against Vero non-cancerous cell line was investigated and the results reflected a high safety profile of all tested compounds. Compound 12a was further investigated for its apoptotic behaviour by assessing the gene expression of four genes (Bcl2, Bcl-xl, TGF, and Survivin). Molecular dynamic simulations authenticated the high affinity, accurate binding, and perfect dynamics of compound 12a against VEGFR-2.
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies
Creators: name: Elkady, Hazem
name: Elwan, Alaa
name: El-Mahdy, Hesham A.
name: Doghish, Ahmed S.
name: Ismail, Ahmed
name: Taghour, Mohammed S.
name: Elkaeed, Eslam B.
name: Eissa, Ibrahim H.
name: Dahab, Mohammed A.
name: Mahdy, Hazem A.
name: Khalifa, Mohamed M.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology

description: A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and HepG2. Also, the effect of the most cytotoxic derivatives on VEGFR-2 protein concentration was assessed by ELISA. Compounds 14o, 14l, and 14b showed the highest activities with VEGFR-2 protein concentrations of 586.3, 636.2, and 705.7 pg/ml, respectively. Additionally, the anti-angiogenic property of compound 14b against human umbilical vascular endothelial cell (HUVEC) was performed using a wound healing migration assay. Compound 14b reduced proliferation and migratory potential of HUVEC cells. Furthermore, compound 14b was subjected to further biological investigations including cell cycle and apoptosis analyses. Compound 14b arrested the HepG2 cell growth at the Pre-G1 phase and induced apoptosis by 16.52%, compared to 0.67% in the control (HepG2) cells. The effect of apoptosis was buttressed by a 4.8-fold increase in caspase-3 level compared to the control cells. Besides, different in silico docking studies were also performed to get better insights into the possible binding mode of the target compounds with VEGFR-2 active sites.
title: Die Gewölbe der Großen Moschee von Córdoba und der islamische Osten. Ursprung, Verbreitung und Auflösung eines Wölbsystems
title: Die Gewölbe der Großen Moschee von Córdoba und der islamische Osten. Ursprung, Verbreitung und Auflösung eines Wölbsystems
titleType: Subtitle
Creators: name: Giese-Vögeli, Francine
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Große Moschee von Córdoba
subject: Rippengewölbe
subject: orientalischer Einfluss
subject: Great Mosque of Córdoba
subject: ribbed vaulting
subject: oriental influence
subject: Gran Mezquita de Córdoba
subject: bóveda nervada
subject: influencia oriental

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Die um 965 im Auftrag al-Hakams II. entstandenen Gewölbe der Großen Moschee von Córdoba sind die ältesten bislang bekannten Vertreter eines Wölbtypus, bei dem ein System sich kreuzender Rippen ein zentrales, von einer Kuppel oder einer Laterne besetztes Scheitelfeld umschreibt. Für diesen Wölbtypus wird hier der Begriff ›nonradiales Rippengewölbe‹ eingeführt. Die kontrovers diskutierte Frage nach der Herkunft besagter Wölbform konnte durch die Neubewertung der 1949 von André Godard vorgelegten Daten zum iranischen Wölbbau und die Untersuchung ostislamischer Beispiele entscheidend geklärt werden. Die dabei gewonnenen Erkenntnisse bekräftigen die bereits früher geäußerte These eines persischen Ursprungs. Zudem wird dargelegt, wie das nonradiale Rippengewölbe im Westen von Córdoba nach Nordafrika ausstrahlte, während es im Osten von Isfahan bis nach Samarkand Verbreitung fand. Im Verlaufe dieses Prozesses wurden die Cordobeser und Isfahaner Vorgaben verändert. Generell lässt sich die Tendenz von einer konstruktiven hin zu einer dekorativen Funktion beobachten. Während im ostislamischen Bereich das Rippensystem zusehends hinter einer ornamentalen Stuckschale verschwand, wurden die Rippen im islamischen Westen in den Stuck integriert und erhielten eine rein dekorative Bedeutung.
title: Guarrazar (Provinz Toledo). Bericht zu den Untersuchungen 2002 bis 2005
title: Guarrazar (Provinz Toledo). Bericht zu den Untersuchungen 2002 bis 2005
titleType: Subtitle
Creators: name: Eger, Christoph
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Guarrazar
subject: Schatzfund
subject: Survey
subject: geophysikalische Prospektion
subject: Westgotenzeit
subject: islamische Epoche
subject: ländliche Siedlung
subject: Guarrazar
subject: treasure
subject: survey
subject: geophysical survey
subject: Visigothic period
subject: Islamic period
subject: rural settlement
subject: Guarrazar
subject: tesoro
subject: prospección arqueológica
subject: prospección geofísica
subject: época visigoda
subject: época islámica
subject: yacimiento rural

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Der Fundplatz Guarrazar ist durch den westgotenzeitlichen Schatzfund von 1858 bekannt geworden, jedoch bald darauf aus dem Blick der Forschung geraten. Der Kontext des Schatzfundes und die Besiedlung Guarrazars in westgotischer und islamischer Zeit blieben im Dunkeln. Von 2002 bis 2005 führte das Deutsche Archäologische Institut Untersuchungen durch, die Surveys, geophysikalische Prospektionen und kleinere Ausgrabungen umfassten. Die bei den Surveys aufgesammelte Keramik gehört zum größten Teil in die islamische Zeit. Erstaunlich ist der ganz geringe Anfall westgotenzeitlicher Keramik. Fragmente westgotenzeitlicher Bauornamentik und große Steinquader, wie sie für die westgotische Architektur typisch sind, lassen an der Besiedlung und Bedeutung Guarrazars im 6. und 7. Jh. aber keinen Zweifel. Die geopyhsikalische Prospektion konnte auf der obersten Geländeterrasse (Terrasse 4) und ganz im Osten des Fundplatzes (Terrasse 3b und Umfeld) umfangreiche Gebäudestrukturen ausmachen. Ein genauer Grundriss der einzelnen Gebäude, ihre Funktion und Datierung sind allerdings ohne großflächige Ausgrabungen nicht zu bestimmen. Bei Ausgrabungen im Bereich der Terrasse 2 konnten 2004 in drei Schnitten gut erhaltene, bis zu 0,7 m hohe Mauerzüge dokumentiert werden, deren jüngste Nutzung in arabische Zeit (10./11. Jh.) fällt. Die Befunde weisen zu dieser Zeit auf eine ländliche Besiedlung. Obwohl weiterhin mit Unwägbarkeiten behaftet, lässt sich die Lokalisierung der Schatzfundstelle und der alten Grabung von de los Ríos nach den vorliegenden Ergebnissen im Gelände deutlich eingrenzen. Das seinerzeit angeschnittene Gräberfeld mit dem kleinen Grabbau und der Schatzfundstelle dürfte im Bereich von Terrasse 1 zu suchen sein.
title: Ein neues Fragment eines Reliefsarkophages aus Quinta de Marim (Olhão, Distrikt Faro, Portugal). Bemerkungen zur Sarkophagbestattung in der Lusitania
title: Ein neues Fragment eines Reliefsarkophages aus Quinta de Marim (Olhão, Distrikt Faro, Portugal). Bemerkungen zur Sarkophagbestattung in der Lusitania
titleType: Subtitle
Creators: name: Graen, Dennis
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Römische Reliefsarkophage
subject: Darstellungen der Weinlese
subject: cupae
subject: Roman relief-sarcophagi
subject: indimiarepresentations
subject: cupae
subject: sarcófagos romanos con representaciones en relieve
subject: escenas de vendimia
subject: cupae

description: Madrider Mitteilungen, Vol. 48 (2007)
description: Im Umfeld von zwei römischen Mausoleen auf dem Gelände einer Villa in Quinta de Marim konnte im Rahmen einer Ausgrabung ein Fragment von der Randleiste eines marmornen Sarkophagdeckels geborgen werden. Das Fragment zeigt zwei Beine, die vermutlich zu einem Eros/Putto bei der Weinlese gehören. Vindemia-Szenen finden sich häufig auf Kinder- und Frauensarkophagen zwischen dem späten 2. und frühen 4. Jh. n. Chr. und drücken als Symbole einer felicitas temporum die Hoffnung auf Üppigkeit und Wohlleben im Jenseits aus, wobei die Eroten und Putti auch auf die verstorbenen Kinder verweisen. Reliefsarkophage sind in der Provinz Lusitania nur punktuell verbreitet, was in dem generellen Fehlen von Sarkophagbestattungen in der frühen Kaiserzeit, der für die Romanisierung Hispaniens wichtigsten Phase, begründet sein mag. Als Reliefsarkophage im Laufe des 2. Jhs. in Rom in Mode kommen, sind in der Lusitania die Verbindungen mit Nordafrika bereits enger als mit Italien; so findet anstelle von Reliefsarkophagen die vermutlich aus Nordafrika übernommene cupa weite Verbreitung in der westlichsten Provinz.
Nutritional and Functional Properties of Two Dried Brown Seaweeds Sirophysalis trinodis and Polycladia myrica
Creators: name: Yasaman Etemadian
name: Shabanpour, Bahareh
name: Ramzanpour, Zohreh
name: Shaviklo, Amir Reza
name: Moazameh Kordjazi
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Sirophysalis trinodis and Polycladia myrica, two brown seaweeds present on the southeast coast of Iran, were evaluated for their nutritional and functional properties after drying. Fourier transform-infrared spectroscopy (FTIR) analysis of crude polysaccharides revealed the characteristic absorption bands of phenol, O–H, C–H, C–O–S, C–O, C=O, C–H groups, and β-glycosidic linkages from cellulose, with the sulfate contents estimated as 4.89 ± 0.11% and 6.96 ± 0.05% of SO4−2. Results of nutritional profiles revealed all of the essential amino acids, especially methionine, isoleucine, leucine, lysine, threonine, valine, phenyl alanine, and arginine. In addition, important fatty acids such as linolenic acid, palmitic acid, and oleic acid were found in high amounts. The other nutritional components present in high amounts were proline and minerals such as calcium, magnesium, iron, manganese, copper, and zinc. The antibacterial activity was weak, but the result of antioxidant activities (hydroxyl and superoxide radicals scavenging and ferrous-ion chelating ability) of crude polysaccharides was considerable. In general, the findings of this study recommend that S. trinodis and P. myrica dried seaweeds have a potent nutritional value and might be used as a valuable source of nutrient supplements for humans and animals.