cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Personality Dysfunction Manifest in Words: Understanding Personality Pathology Using Computational Language Analysis
Creators: name: Entwistle, Charlotte
Publisher: name: University of Liverpool Repository
Year: 2024

description: Personality disorders (PDs) are some of the most prevalent and high-risk mental health conditions, and yet remain poorly understood. Today, the development of new technologies means that there are advanced tools that can be used to improve our understanding and treatment of PD. One promising tool – indeed, the focus of this thesis – is computational language analysis. By looking at patterns in how people with personality pathology use words, it is possible to gain access into their constellation of thinking, feelings, and behaviours. To date, however, there has been little research at the intersection of verbal behaviour and personality pathology. Accordingly, the central goal of this thesis is to demonstrate how PD can be better understood through the analysis of natural language. This thesis presents three research articles, comprising four empirical studies, that each leverage computational language analysis to better understand personality pathology. Each paper focuses on a distinct core feature of PD, while incorporating language analysis methods: Paper 1 (Study 1) focuses on interpersonal dysfunction; Paper 2 (Studies 2 and 3) focuses on emotion dysregulation; and Paper 3 (Study 4) focuses on behavioural dysregulation (i.e., engagement in suicidality and deliberate self-harm). Findings from this research have generated better understanding of fundamental features of PD, including insight into characterising dimensions of social dysfunction (Paper 1), maladaptive emotion processes that may contribute to emotion dysregulation (Paper 2), and psychosocial dynamics relating to suicidality and deliberate self-harm (Paper 3) in PD. Such theoretical knowledge subsequently has important implications for clinical practice, particularly regarding the potential to inform psychological therapy. More broadly, this research highlights how language can provide implicit and unobtrusive insight into the personality and psychological processes that underlie personality pathology at a large-scale, using an individualised, naturalistic approach.
Canaceoides angulatus Wirth 1969
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Canaceoides
Canaceoides angulatus

description: angulatus Wirth
Canaceoides angulatus Wirth, 1969a: 556. Wirth 1975: 2 [catalogue]; Linsley 1977: 42 [checklist]; Arnaud 1979: 346 [type catalogue]; Mathis 1992: 7 [catalogue]; Munari & Mathis 2010: 19 [catalogue].
Distribution. Native. Nearctic, Neotropical, Hawaii; Galápagos: Española, Floreana, Pinta, Santa Cruz, Santa Fé, Seymour.
Remarks. Adults of this species were collected on intertidal rocks (Wirth 1969b).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on pages 67-68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Aegorhinus Erichson
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Aegorhinus

description: Aegorhinus Erichson
= Psuchocephalus Latreille 1828: 597 (type species: Curculio leprosus Olivier [non Gmelin] [= C. vitulus, Fabricius]).
Aegorhinus Erichson 1834: 261 (type species: A. phaleratus Erichson, by indication, monotypy).
= Lophotus Schoenherr 1834: 314 (type species: L. eschscholtzi Boheman [= A. superciliosus (Guérin-Méneville)] by original designation; preoccupied).
= Lophodes Dejean 1837: 284 (nomem nudum).
= Eublepharus Gay & Solier 1839: 11 (type species not designated, not available).
= Ceropsis Gay & Solier 1839: 19 (type species not designated, not available).
= Sublepharus Desbrochers 1910: 130 (nomem nudum).
= Aegorrhinus Bruch 1915: 416 (lapsus).
= Euplepharus Bruch 1915: 416 (lapsus).
= Micropolus Kuschel 1952b: 243 (type species: Lophotus delfini Germain, by original designation).
Aegorhinus delfini (Germain) (Fig. 13 A–B)
Lophotus delfini Germain 1893: 1031; Desbrochers 1910: 130 (Aterpus); Marshall 1946: 94 (Aegorhinus); Kuschel 1952b: 243 (Micropolus); Morrone & Roig-Juñent 2000 (Aegorhinus).
= Aegorhinus boniarde Cekalovic 1970: 56.
Geographic distribution as in figure 12.
Specimens examined: ARGENTINA: Tierra del Fuego, PN Tierra del Fuego, Arroyo Los Castores, II–26 / 28–1997, Posadas & Ocampo col. (4 specimens with same data MLP); Ushuaia, Valle Andorra, XI–18–1984, Sobral col. (MLP).
Temporal distribution: November to February.
Plant association: Several specimens associated with Nothofagus forests or collected on Nothofagus and Gunnera.
It had been considered that the distribution of A. delfini includes Maule and the Magellanic forest biogeographical provinces (Morrone & Roig-Juñent 1995, 2000). However, Elgueta (2000) considered that A. delfini is endemic to the Magellanic forest and that its records from Maulean areas are incorrect.
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on page 17, DOI: 10.5281/zenodo.213158
Tobacco-use by LGBTQ youth: prevalence and correlates
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed study will focus on an under-researched population, LGBTQ (Lesbian, Gay, Bisexual, Transgender, and Questioning) youth. Both youth and the LGBT community are priority groups specifically identified by the TRDRP. Currently, there are few studies that look specifically at LGBTQ youth rates of tobacco use and even fewer that examine the correlates for (factors associated with) tobacco use among this understudied population. The handful of studies that exist show that rates of tobacco use among lesbian, gay, and bisexual (LGB) youth are significantly higher than those of their heterosexual (H) peers and that factors often experienced by LGB youth such as lack of family acceptance, school bullying, harassment and victimization are related to observed higher engagement in tobacco use and other high-risk behaviors. Even less has been published on the patterns and potential correlates of tobacco use within the LGB adolescent community and nothing has been published on LGB youth of color. Furthermore, no research with adequate samples has been published on tobacco use by transgender (T) youth, who, along with LGB and questioning (Q) youth, make up the full range of sexual minority youth as defined by policy makers and health-promotion practitioners and stakeholders in California i.e., LGBTQ youth.

 The overall aim of the study is to utilize and examine existing data from San Francisco Unified School District’s (SFUSD) High School Youth Risk Behavior Survey (YRBS) from 2001-2011. The specific research questions the study will address are:

 1. What are the rates of tobacco use among males, females and race/ethnic groups of LGBTQ and H youth attending public high school in San Francisco during 2001-2011?

 2. Which demographic, contextual and health risk behavior variables were most associated with tobacco use in the subgroups of LGB and H students attending high school in SFUSD during 2001-2011?

 3. How do factors common to both groups differ in the strength of their relationship to tobacco use among H versus LGB students?

 The proposed work will yield some of the first findings on a significantly understudied, diverse, and hard to reach population LGBTQ youth. The proposed study will provide results that can be used with confidence by California’s tobacco control advocates (e.g., California’s Tobacco Control Program and the California Department of Education’s Healthy Kids Program) to more effectively target prevention and cessation programming for California’s LGBTQ youth. The results will also provide a foundation for further research into the patterns and predictors of tobacco use among this understudied population.
Liolaemus kolengh Abdala & Lobo 2006
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus kolengh

description: Liolaemus kolengh Abdala & Lobo
Liolaemus kolengh Abdala & Lobo 2006b: 2 (type locality: Ceballos Hill way, near to Río Ceballos [47°01.542’S, 71°48.475’W], 1485 m, Lago Buenos Aires Department, Santa Cruz Province, Argentina); Pincheira-Donoso & Scolaro 2007: 57.
Liolaemus lineomaculatus Boulenger
Proctotretus kingii Bell 1843: 13 (in part, fide Donoso-Barros 1966a); Gray 1845: 215 (in part, fide Donoso-Barros 1966a).
Liolaemus lineomaculatus Boulenger 1885a: 149 (type locality: “Patagonia”. Restricted to Puerto Deseado, Patagonia, Argentina, by Donoso-Barros 1966a); Koslowsky 1895: 363, 1896: 450; Andersson 1898: 461; Stejneger 1909: 217; Burt & Burt 1931: 275, 1933: 33; Liebermann 1939: 72; Donoso-Barros & Codoceo 1962: 28; Donoso-Barros 1966a: 275, 1970a: 185; 1970b: 93; Cei 1971b: 417, 1974c: 183, 1986: 264; Porter 1972: 401; Vanzolini 1986: 15; Veloso & Navarro 1988: 506; Núñez & Jaksic 1992: 74; Pereyra et al. 1992: 277; Scolaro 1992: 287; Etheridge 1995: 33; Videla & Cei 1998: 63; Etheridge & Espinoza 2000: 7; Schulte et al. 2000: 78; Lobo 2001: 139; Chebez et al. 2005: 32; Scolaro 2005: 41; Sura 2005: 429; Pincheira-Donoso & Scolaro 2007: 57.
Liolaemus hatcheri Stejneger 1909: 218 (see Scolaro & Cei 2002).
Vilcunia lineomaculatus Laurent 1985b: 7.
Liolaemus (Liolaemus) lineomaculatus Pincheira-Donoso & Núñez 2005: 293.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 38, DOI: 10.5281/zenodo.6789337
Role for fibroblasts in the chronic immune response in COPD
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic Obstructive Lung Disease (COPD) is caused by loss of the walls of air sacs and by narrowing of the airways due to scarring. Currently, there are no effective therapies to treat COPD. While the loss of alveoli is unlikely to be reversible, the narrowing of the airways represents a possible therapeutic target. TGF-B is a potent molecule that causes scarring and there is ample evidence that it plays a role in airway wall narrowing. However, TGF-B must be made active before it can function. Our published and preliminary data suggest that in COPD, enhanced TGF-B activation is cause by molecules, called integrins, located on the surface of airway cell types. Our published studies demonstrate that integrin-mediated TGF-B activation in airway cell types correlates with worsening airway obstruction. Our pilot experiments using genetic deletion of a particular integrin, avB8 blocks airway inflammation and fibrosis in a mouse COPD model. This data suggests that the integrin avB8 might be novel therapeutic targets in COPD.The roles of the various airway cell types (i.e. epithelium, immune cells and fibroblasts) that are implicated in airway narrowing in COPD are not completely understood. Our work proposed here is the first to directly implicate the fibroblast in contributing to the abnormal persistent inflammatory response that characterizes COPD. We propose experiments that characterize the mechanisms involved in fibroblast regulation of pathologic inflammation. This work identifies several unique targets to block both inflammation and fibrosis in COPD.This new work represents three entirely new directions for our laboratory 1) developing mouse models of airway disease; 2) studying pathologic immunity; 3) studying the in vivo effects of tobacco smoke. The successful completion of the proposed experiments will allow our laboratory to establish the facility, methodology and expertise to study tobacco related lung disease in mice.In this proposal we test the hypothesis that the integrin avB8 contributes pathologic inflammation and fibrosis in airway remodeling in COPD.We will use genetic deletion models combined with the use of biospecimens to maximize the application of our findings to human COPD. The successful completion of this project will be a crucial translation step in establishing the role and mechanism of integrin-mediated TGF-B activation in small airways disease in COPD.
Aegorhinus vitulus Fabricius
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Aegorhinus
Aegorhinus vitulus

description: Aegorhinus vitulus (Fabricius)
(Fig. 13 C–D)
Curculio vitulus Fabricius 1775: 152; Hope 1834: 16 (Lophotus); Blanchard 1851: 329 (Eublepharus); Marshall 1946: 94 (Aegorhinus).
= Curculio leprosus Olivier 1807: 395; Lacordaire 1863: 414 (Lophotus); Marshall 1946: 94 (Aegorhinus).
Geographic distribution as in figure 12.
Specimens examined: ARGENTINA: Tierra del Fuego, Río Olivia, I-20-1997, Amado col. (MLP); Bahía Thetys, II-20-1951, Torres col. (4 specimens with same data, MLP); Lago Fagnano (on Nothofagus), I-1939 (MLP). CHILE: Magallanes, Isla Navarino, Seno Grandi (55ºS, 20ft, Nothofagus forest), II-6-1959 (4 specimens with same data, BMNH); (BMNH); Puerto Williams (55ºS, 1200ft), I-12-1959 (BMNH); Isla Picton (55ºS, 25ft, Nothofagus forest), II-1-1959 (BMNH);
Temporal distribution: October to February.
Plant association: Several specimens associated with Nothofagus forests or collected on Nothofagus.
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on pages 18-19, DOI: 10.5281/zenodo.213158
Additional file 1: of A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission
Creators: name: Shepperd, Sasha
name: Cradduck-Bamford, Andrea
name: Butler, Chris
name: Ellis, Graham
name: Godfrey, Mary
name: Gray, Alastair
name: Hemsley, Anthony
name: Khanna, Pradeep
name: Langhorne, Peter
name: McCaffrey, Patricia
name: Lubena Mirza
name: Pushpangadan,
name: Ramsay, Scott
name: Schiff, Rebekah
name: Stott, David
name: Young, John
name: Ly-Mee Yu
Publisher: name: Figshare
Year: 2017
Subjects: Medicine
Cancer
Science Policy
Mental Health

description: Standard Protocol Items Recommendations for Interventional Trials (SPIRIT) 2013 checklist recommended items to address in a clinical trial protocol and related documents. (DOC 121Â kb)
Old coal power plants: Lost memory of electricity production in Asturias
Creators: name: Anes, Noe
name: Marques Sierra, Antonio Luis
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 330103
subject: Architectural heritage and conservation

description: Communication publish in the Book of Abstracts of the II JORNADAS INTERNACIONAIS “MEMÓRIAS DO CARVÃO”, organized in Rio Maior (Portugal), 17 a 19 de novembro de 2022
Nocticanace ashlocki Wirth 1969
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Nocticanace
Nocticanace ashlocki

description: ashlocki Wirth
Nocticanace ashlocki Wirth, 1969b: 589. Wirth 1975: 2 [catalogue]; Linsley 1977: 41 [checklist]; Arnaud 1979:
347 [type catalogue]; Mathis 1992: 8 [catalogue]; Munari & Mathis 2010: 21 [catalogue].
Distribution. Endemic. Galápagos: Santa Cruz.
Remarks. Adults of this species were collected on coastal rocks and beaches (Wirth 1969b). At CDRS, both N. ashlocki and N. galapagensis have been collected together with Paracanace cavagnaroi and Canaceoides angulatus among the intertidal rocks and sand (B.J. Sinclair unpub.).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Sirtuin deacetylase and RAS-dependent cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: SIRT1 is an enzyme that removes the acetyl group from acetylated lysine in a protein, i.e. deacetylation. The deacetylation reaction results in positive charges on lysine residues on a protein. SIRT1 plays important roles for promoting mammalian cell survival under many physical, metabolic and environmental stresses. SIRT1 protein is over-produced in many human cancers, but its roles in cancer are not well defined. By extensive work, my laboratory has recently identified crucial roles of SIRT1 gene expression activated by BCR-ABL, a cancer-causing gene for chronic myelogenous leukemia, for efficient BCR-ABL transformation of normal hematopoietic progenitor cells to leukemic cells and chemoresistance of chronic myelogenous leukemia. RAS oncogenes are among the most frequently mutated genes in human malignancies, especially in lung, pancreas, colon/intestine, biliary tract and skin cancers. Tobacco smoking increases or is associated with mutations of RAS oncogenes in lung cancer. Mutant RAS-driven cancers are highly chemoresistant and notoriously difficult to treat. RAS oncoproteins are localized onto cellular membranes for their biological functions through adding a fatty acid chain, a process termed farnesylation; however, pharmacological inhibition of farnesylation is largely ineffective for cancer treatment and molecular mechanism for this failure is not clear. We hypothesize that SIRT1 may have a broad role in oncoprotein-mediated chemoresistance. We have found that SIRT1 is crucial for RAS transformation of normal cells to cancer cells, and that RAS proteins are subjected to modification by lysine acetylation. We propose that SIRT1 may regulate RAS functions by deacetylation resulting in positive charges on RAS protein, which provides an alternative way for RAS activation when farnesylation is blocked. If it proves true, simultaneous blocking RAS deacetylation and farnesylation may dramatically inhibit RAS functions. Since SIRT1 can deacetylate many proteins working on large complexes or on the same networks, we also propose to examine roles of SIRT1 for regulating several mutant KRAS downstream effectors by protein deacetylation. These studies will significantly help us understand how SIRT1 may play specific roles in cancer and how deacetylation may contribute to mutant KRAS oncogenic signaling. Successful completion of proposed studies may have direct implication for improving treatment of RAS-dependent cancers including mutant RAS-bearing lung cancer by combinatory inhibition of SIRT1 deacetylation and RAS farnesylation or RAS downstream effectors.
Alastoropolus Kuschel
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Alastoropolus

description: Alastoropolus Kuschel
Alastoropolus Kuschel 1950: 15 (type species: Curculio strumosus Olivier, by original designation).
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on page 19, DOI: 10.5281/zenodo.213158
The Triple Helix Model of Innovation: An Analysis of Scientific Production Item
Creators: name: Gálvez, Carmen
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 470101
subject: Communication studies
classificationCode: 470106
subject: Media industry studies
classificationCode: 470107
subject: Media studies

description: This paper analyzes the scientific production on the Triple Helix model, based on the interaction between university-industry-government, which highlights the relevance of the role of universities in the transition from an industrial society to another based on knowledge. Bibliometric indicators and factor analysis techniques were used. A total of 593 publications indexed in the central collection of Web of Science (WoS) were retrieved, from 1993 to 2022. The most productive authors, countries, institutions and journals, the manuscripts with the greatest impact and the thematic and conceptual structure in the scientific field analyzed.
Nocticanace cancer Wirth 1969
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Nocticanace
Nocticanace cancer

description: cancer Wirth
Nocticanace cancer Wirth, 1969b: 586. Wirth 1975: 2 [catalogue]; Linsley 1977: 41 [checklist]; Mathis 1992: 8 [catalogue]; Munari & Mathis 2010: 21 [catalogue].
Distribution. Endemic. Galápagos: Pinta.
Remarks. Adults of this species were reported on crabs (Wirth 1969b).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Nocticanace curioi Wirth 1969
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Nocticanace
Nocticanace curioi

description: curioi Wirth
Nocticanace curioi Wirth, 1969b: 583. Wirth 1975: 2 [catalogue]; Linsley 1977: 41 [checklist]; Mathis 1992: 8 [catalogue]; Munari & Mathis 2010: 21 [catalogue].
Distribution. Endemic. Galápagos: Pinta, Wolf.
Remarks. In the evenings, adults of N. curioi rest on the backs of the crab Grapsus grapsus (L.), which rests in dry places. During the day, the flies feed on the thin organic film covering rocks of the intertidal zone (Curio 1964).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Alastoropolus strumosus Olivier
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Alastoropolus
Alastoropolus strumosus

description: Alastoropolus strumosus (Olivier)
Curculio strumosus Olivier 1807: 394; Lacordaire 1863: 414 (Lophotus); Marshall 1946: 94 (Aegorhinuss); Kuschel 1952b: 217 (Alastoropolus).
= Lophotus longipes Waterhouse 1840: 330; Blanchard 1851: 329 (Eublepharus); Marshall 1946: 94 (Aegorhinus). Geographic distribution as in figure 14.
Specimens examined: ARGENTINA: Tierra del Fuego, without more data, Bruch col. (2 specimens with same data MACN). CHILE: Llanquihue, Puerto Montt, 15-II-1971 (2 specimens with same data MHNS). Temporal distribution: February.
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on pages 19-20, DOI: 10.5281/zenodo.213158
Additional file 3: of Antipsychotics and dementia in Canada: a retrospective cross-sectional study of four health sectors
Creators: name: Rios, Sebastian
name: Perlman, Christopher
name: Costa, Andrew
name: Heckman, George
name: Hirdes, John
name: Mitchell, Lori
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Proportion of individuals 65Â years of age or older who used an antipsychotic by Province/Territory, Health Sector, and Symptom Status. (DOCX 16Â kb)
Valorisation of the stabilized organic fraction of mixed municipal waste as building materials within a circular economy
Creators: name: Mendes dos Santos, Michael
name: Marques Sierra, Antonio Luis
name: Amado-Fierro, Alvaro
name: Suárez, Marta
name: González La Fuente, José Manuel
name: Antonia Diez, María
name: A. Centeno, Teresa
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 330206
subject: Building science, technologies and systems

description: Communication publish in the Book of Abstracts of the 12th international conference of the International Ecological Engineering Society “Closed cycles and the Circular Society 2023: The power of ecological engineering”, organized in Chania, Greece between 1-5 October 2023.
Liolaemus silvanae
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus silvanae

description: Liolaemus silvanae (Donoso-Barros & Cei)
Vilcunia silvanae Donoso-Barros & Cei 1971: 91 (type locality: Puesto Lebrún, 1400 m, Meseta Lago Buenos Aires, Santa Cruz Province, Argentina); Cei 1973c: 1, 1982c: 213, 1986: 266; Cei & Scolaro 1982a: 360; Christie 1984b: 541.
Liolaemus sylvanae Etheridge 1995: 33; Etheridge & Espinoza 2000: 9; Sura 2005: 430.
Liolaemus silvanae Chebez et al. 2005: 35; Scolaro 2005: 49; Pincheira-Donoso & Scolaro 2007: 57.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 38, DOI: 10.5281/zenodo.6789337
Paratlantoscia rubromarginata
Creators: name: Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Philosciidae
Paratlantoscia
Paratlantoscia rubromarginata

description: 76. Paratlantoscia rubromarginata (Araujo and Leistikow, 1999)
Atlantoscia rubromarginata Araujo and Leistikow, 1999: 110, figs. 1–5. – Leistikow, 2001b: 6. – Schmalfuss, 2003: 49. – Campos-Filho et al., 2012: 141. – Campos-Filho et al., 2013b: 466, fig.12b. – Lisboa et al., 2013: 394. – Zimmermann et al., 2015b: 704, figs. 5, 6, Tabs. 1–3. – Zimmermann et al., 2015a: 3, Tab. 1.
Paratlantoscia rubromarginata – Zimmermann et al., 2018a: 474, Tabs. 1, 2, figs. 5, 6.
Distribution. Endemic to Brazil (states of Alagoas, Bahia, Pará, and Sergipe) (Campos-Filho et al., 2013b; 2017c).
description: Published as part of Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio, 2018, Catalogue of terrestrial isopods (Crustacea, Isopoda, Oniscidea) from Brazil: an update with some considerations, pp. 1-40 in Nauplius (e 2018038) (e 2018038) 26 on page 14, DOI: 10.1590/2358-2936e2018038, http://zenodo.org/record/14666839
MOESM2 of Integrated community case management by drug sellers influences appropriate treatment of paediatric febrile illness in South Western Uganda: a quasi-experimental study
Creators: name: Kitutu, Freddy
name: Kalyango, Joan
name: Chrispus Mayora
name: Selling, Katarina
name: Peterson, Stefan
name: Wamani, Henry
Publisher: name: Figshare
Year: 2017
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Table showing proportions: classification and treatment of children attending drug shops in Intervention arm in South Western Uganda from February 2014 to September 2015; comparison of different data sources.
Use of Abandoned Mines (USAMIN) a Mining Heritage Preservation Training Initiative
Creators: name: Marques Sierra, Antonio Luis
name: Iglesias Rodríguez, Francisco Javier
name: Riesgo Fernández, Pedro
name: Šancer, Jindřich
name: Zubíček, Václav
name: Kluzová, Eva
name: Klempa, Martin
name: Moellerherm, Stefan
name: Dogan, Tansel
name: Pach, Grzegorz
name: Niewiadomski, Adam
name: Różański, Zenek
name: Bennewitz, Evelyn
name: Konietzky, Heinz
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 330103
subject: Architectural heritage and conservation
classificationCode: 401905
subject: Mining engineering

description: Communication publish in the Book of Abstracts of the II JORNADAS INTERNACIONAIS “MEMÓRIAS DO CARVÃO”, organized in Rio Maior (Portugal), 17 a 19 de novembro de 2022
Nocticanace darwini Wirth 1969
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Nocticanace
Nocticanace darwini

description: darwini Wirth
Nocticanace darwini Wirth, 1969b: 585. Wirth 1975: 3 [catalogue]; Linsley 1977: 41 [checklist]; Mathis 1992: 9 [catalogue]; Munari & Mathis 2010: 22 [catalogue].
Distribution. Endemic. Galápagos: Fernandina, Genovesa.
Remarks. Adults of this species were reported nesting on the backs of crabs among intertidal rocks (Wirth 1969b).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Antarctobius Fairmaire
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Antarctobius

description: Antarctobius Fairmaire
Antarctobius Fairmaire 1885: 58 (type species: A. lacunosus Fairmaire, subsequent designation by Morrone 1992a).
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on page 20, DOI: 10.5281/zenodo.213158
Liohippelates galapagensis
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Liohippelates
Liohippelates galapagensis

description: galapagensis (Curran)
Procance galapagensis Curran, 1934: 160.
Nocticanace galapagensis: Wirth 1951: 274 [transferred to Nocticance]; Wirth 1969b: 581 [revision]; Linsley & Usinger 1966: 170 [checklist]; Wirth 1975: 3 [catalogue]; Linsley 1977: 41 [checklist]; Arnaud 1979: 348 [type catalogue]; Mathis 1992: 9 [catalogue]; Munari & Mathis 2010: 22 [catalogue].
Distribution. Endemic. Galápagos: Fernandina, Isabela, Pinta, San Cristóbal, Santa Cruz, Seymour, Wolf.
Remarks. Similar habits as N. curioi (Wirth 1969b).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Antarctobius germaini Kolbe
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Antarctobius
Antarctobius germaini

description: Antarctobius germaini (Kolbe)
= Listroderes griseus Germain 1896: 829 (preoccupied).
Listroderes germaini Kolbe 1907: 105 (replacement name for L. griseus Germain); Morrone 1992a: 12 (Antarctobius).
Geographic distribution as in figure 12.
Specimens examined: ARGENTINA: Tierra del Fuego, Bahía Thetys, II-20-1951, Torres col. (MLP); Ushuaia (costa) XI-5-1984, Sobral col. (MLP).
Temporal distribution: November to July.
Plant association: Senecio allocophyllus and Senecio candidans (Morrone 1992a)
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on page 20, DOI: 10.5281/zenodo.213158
Additional file 2: of Impact of a community health worker HIV treatment and prevention intervention in an HIV hotspot fishing community in Rakai, Uganda (mLAKE): study protocol for a randomized controlled trial
Creators: name: Chang, Larry
name: Mbabali, Ismail
name: Xiangrong Kong
name: Hutton, Heidi
name: K. Amico
name: Kennedy, Caitlin
name: Nalugoda, Fred
name: Serwadda, David
name: Bollinger, Robert
name: Quinn, Thomas
name: Reynolds, Steven
name: Gray, Ronald
name: Wawer, Maria
name: Nakigozi, Gertrude
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Rakai Health Sciences Program mLAKE (mHealth Lakefolk Actively Keeping Engaged) Application. (DOCX 92 kb)
Antarctobius hyadesii Fairmaire
Creators: name: Posadas, Paula
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Antarctobius
Antarctobius hyadesii

description: Antarctobius hyadesii Fairmaire
(Fig. 13 E–F)
Antarctobius hyadesii Fairmaire 1885: 58; Enderlein 1907: 39 (Listroderes). = Listroderes laevigatus Germain 1896: 801.
Geographic distribution as in figure 12.
Specimens examined: Tierra del Fuego, Bahía Thetys, II-20-1951, Torres col. (MLP). CHILE, Magallanes, Isla Navarino, Puerto Williams (55°S, 1900ft), I-21-1959 (BMNH). Temporal distribution: January to April.
Plant association: Senecio allocophyllus (Morrone 1992a)
description: Published as part of Posadas, Paula, 2012, Species composition and geographic distribution of Fuegian Curculionidae (Coleoptera: Curculionoidea), pp. 1-36 in Zootaxa 3303 on page 20, DOI: 10.5281/zenodo.213158
Eulaemus Girard. 1858
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Eulaemus

description: Subgenus Eulaemus Girard
Ptychodeira Fitzinger 1843: 78 (type species: Proctotretus Fitzingerii Duméril & Bibron 1837).
Ptygoderes Gray 1845: 216 (substitute name for Ptychodeira).
Eulaemus Girard 1858a: 198 (type species: Proctotretus fitzingerii Duméril & Bibron 1837).
Ortholaemus Girard 1858a: 198 (type species: Ortholaemus Beaglii Girard 1858a).
Helocephalus Philippi 1860: 167 (type species: Helocephalus nigriceps Philippi 1860).
Pelusaurus Donoso-Barros 1973a: 132 (type species: Pelusaurus cranwelli Donoso-Barros 1973a).
Ceiolaemus Laurent 1984a: 359 (type species: Liolaemus pseudoanomalus Cei 1981).
Abas Núñez & Yánez 1984b: 99 (type species: Liolaemus fabiani Yañez & Núñez 1983).
Velosaura Núñez & Yánez 1984b: 100 (type species: Liolaemus aymararum Veloso, Sallaberry, Navarro, Iturra, Valencia, Penna & Díaz 1982).
Mesolaemus Laurent 1985a: 3 (type species: Liolaemus cuyanus Cei & Scolaro 1980).
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on pages 38-39, DOI: 10.5281/zenodo.6789337
Targeted nanodelivery of anti-inflammatory drugs
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic obstructive pulmonary disease (COPD) is a major killer, accounted for more than 120,000 deaths per year in the United States and for more than 2.7 million deaths per year in the world. Though many factors can contribute to COPD, smoking tobacco is the leading cause of COPD. Smoking leads to inflammation in the lungs, which can lead to COPD and worsen other diseases like asthma. People affected with COPD have greatly restricted lung function, often cough and wheeze, are highly susceptible to lung infections, and have difficulty performing even minor, daily activities due to fatigue and shortness of breath. Tragically, there is no cure for COPD. Quitting smoking is vital to slow the progression of the disease, but current therapies are largely ineffective and can have severe side effects. New therapies are desperately needed. Because inflammation is an important of COPD, new therapies could also benefit other lung inflammatory diseases, such as asthma.

 When injected intravenously, most small drugs are diluted over the entire body. They are a very small drop in a large, human-sized bucket. If these therapies could instead be targeted to the lungs and concentrated in the lungs, efficacy could be greatly increased. Unfortunately, most of the ways to target antibodies to a single tissue involve large proteins, which can move easily out of the blood and into the tissue because the inner surface of blood vessels is lined with a tight barrier of cells.

 We have shown that there are active shuttles called caveolae that can move drugs across this barrier. We have identified protein markers that are concentrated within caveolae of the lung. These proteins can bind probes that are injected into the blood. Once within caveolae, the probe and any attached cargo is rapidly pumped out of the blood and concentrated in the underlying tissue. Here, we propose that this strategy could be used to target drug carriers to the lungs. Unlike drug alone, the targeted drug would rapidly accumulate only in the lungs. It would then have little to no side effects because the rest of the body never sees the drug. We will first explore anti-inflammatory drugs and determine if incorporation into targeted drug carriers really do make these drugs more effective than free drug against inflammation in the lung.

 This novel strategy has great potential for COPD and asthma. The delivery platform is modular, and different components can be assembled in a tinker toy fashion. Thus, different probes can be used to target different organs. Different drugs can be used to treat different diseases. And different drug carriers can be optimized to work best for each disease. This work, therefore, has a broad impact on many single-organ diseases.
Additional file 2: of Impact of a community health worker HIV treatment and prevention intervention in an HIV hotspot fishing community in Rakai, Uganda (mLAKE): study protocol for a randomized controlled trial
Creators: name: Chang, Larry
name: Mbabali, Ismail
name: Xiangrong Kong
name: Hutton, Heidi
name: K. Amico
name: Kennedy, Caitlin
name: Nalugoda, Fred
name: Serwadda, David
name: Bollinger, Robert
name: Quinn, Thomas
name: Reynolds, Steven
name: Gray, Ronald
name: Wawer, Maria
name: Nakigozi, Gertrude
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Rakai Health Sciences Program mLAKE (mHealth Lakefolk Actively Keeping Engaged) Application. (DOCX 92 kb)
Liolaemus andinus Koslowsky 1895
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus andinus

description: Liolaemus andinus Koslowsky
Liolaemus andinus Koslowsky 1895: 338 (type locality: Andes of Catamarca, between 3000 and 4000 m, Catamarca Province, Argentina); Laurent 1982b: 89; Vanzolini 1986: 12; Núñez 2004: 30; Chebez et al. 2005: 28; Sura 2005: 428.
Liolaemus signifer var. nigriceps Koslowsky 1898: 180 (see Cei 1993).
Ctenoblepharis schmidti Marx 1960: 407 (synonym fide Pincheira-Donoso & Núñez 2005); Donoso-Barros 1966a: 342, 1970a: 104 (in part); Yáñez & Núñez 1982: 12.
Liolaemus multiformis multiformis Donoso-Barros 1970a: 187 (in part).
Ctenoblepharys schmidti Donoso-Barros 1970b: 85 (in part).
Liolaemus multiformis multiformis Donoso-Barros 1970b: 94 (in part).
Liolaemus schmidti Vanzolini 1986: 16; Veloso & Navarro 1988: 511; Núñez & Jaksic 1992: 76; Sura 2005: 430 (in part).
Liolaemus poecilochromus Laurent 1986: 100 (synonym fide Pincheira-Donoso & Núñez 2005); Schulte et al. 2000: 78. (in part); Díaz 2007: 117.
Liolaemus andinus andinus Laurent 1992: 30; Cei 1993: 245; Etheridge 1995: 34; Etheridge & Espinoza 2000: 4.
Liolaemus andinus poecilochromus Halloy et al. 1991: 61; Laurent 1992: 30 (in part); Cei 1993: 248 (in part); Etheridge 1995: 34 (in part); Etheridge & Espinoza 2000: 4 (in part).
Liolaemus molinai Valladares et al. 2002: 477 (synonym fide Pincheira-Donoso & Núñez 2005); Sura 2005: 429 (in part).
Liolaemus (Eulaemus) andinus Pincheira-Donoso 2005: 126; Pincheira-Donoso & Núñez 2005: 152.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 39, DOI: 10.5281/zenodo.6789337
Nocticanace scapania Wirth 1969
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Canacidae
Nocticanace
Nocticanace scapania

description: scapania Wirth
Nocticanace scapanius Wirth, 1969b: 586. Wirth 1975: 3 [catalogue]; Linsley 1977: 41 [checklist]; Arnaud 1979: 348 [type catalogue].
Nocticanace scapania: Mathis 1992: 9 [catalogue]; Munari & Mathis 2010: 23 [catalogue].
Distribution. Endemic. Galápagos: Fernandina, San Cristóbal.
Remarks. Adults of this species were collected on intertidal rocks (Wirth 1969b). Larval trombidiid mites are parasitic on this species (Fain & Grootaert 1993).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 68, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Amazoniscus eleonorae Souza, Bezerra and Araujo 2006
Creators: name: Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Scleropactidae
Amazoniscus
Amazoniscus eleonorae

description: 87. Amazoniscus eleonorae Souza, Bezerra and Araújo, 2006
Amazoniscus eleonorae Souza, Bezerra and Araújo, 2006: 37, figs. 1–20. – Campos-Filho et al., 2014: 361, fig.40. – Pires et al., 2015: 69, Tab.1. – Campos-Filho et al., 2016: 2. – Angarten et al., 2017: 17. – Bastos-Pereira et al., 2017: 292. – Campos-Filho et al., 2017b: 70. – Cavalcanti, 2017: 49, Tab. 2. – Gallão and Bichuette, 2018: 7, Tab. 1.
Distribution. Troglobitic species endemic to Pedra da Cachoeira, Planaltina, and Limoeiro caves, Altamira karst region, state of Pará (Souza et al., 2006).
description: Published as part of Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio, 2018, Catalogue of terrestrial isopods (Crustacea, Isopoda, Oniscidea) from Brazil: an update with some considerations, pp. 1-40 in Nauplius (e 2018038) (e 2018038) 26 on page 16, DOI: 10.1590/2358-2936e2018038, http://zenodo.org/record/14666839
MOESM2 of Integrated community case management by drug sellers influences appropriate treatment of paediatric febrile illness in South Western Uganda: a quasi-experimental study
Creators: name: Kitutu, Freddy
name: Kalyango, Joan
name: Chrispus Mayora
name: Selling, Katarina
name: Peterson, Stefan
name: Wamani, Henry
Publisher: name: Figshare
Year: 2017
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Table showing proportions: classification and treatment of children attending drug shops in Intervention arm in South Western Uganda from February 2014 to September 2015; comparison of different data sources.
Liolaemus annectens Boulenger 1901
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus annectens

description: Liolaemus annectens Boulenger
Liolaemus annectens Boulenger 1901: 546 (type locality: Caylloma and Sumbay, Andes of Perú); Vanzolini 1986: 12; Carrillo de Espinoza & Icochea 1995: 9.
Liolaemus multiformis Hellmich 1962: 2.
Liolaemus multiformis multiformis Donoso-Barros 1970a: 187.
Liolaemus signifer annectens Laurent 1992: 31; Cei 1993: Lam 15, figs 1, 2, 3; Etheridge 1995: 34; Etheridge & Espinoza 2000: 9.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 39, DOI: 10.5281/zenodo.6789337
Dynamic Imaging of Sodium Channels in Metastatic Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer related mortality in the United States. Each year more patients die from lung cancer than from breast, colon, and prostate cancer combined. This alarming statistic is a result of both the frequency and poor prognosis of the disease, with roughly 237,000 new cases each year and only 14% survival of all patients five years after diagnosis. The invasiveness and rapid spread of cancerous cells, or metastasis, within the lung and to other organs is a primary factor linked to the high incidence of mortality. Patients diagnosed with non-metastatic stage IA and IB lung cancer have a five-year survival rate of 67% and 57%, respectively. In contrast, the survival rate for individuals with metastatic lung cancer, classified as stage IV, is only 1%. Our research aims to study a specific class of sodium ion channel proteins that is thought to facilitate metastasis in many cancer types, including small cell and non-small cell lung cancer. Very recent data demonstrates that sodium ion channels are present in certain cancerous cell lines, and that the concentration and cellular distribution of these proteins is linked to cell invasiveness. Efforts to reveal the specific roles of sodium ion channels in cell metastasis can guide the development of novel therapies that arrest the spread of lung cancer.

 Voltage-gated sodium ion channels (NaVs) are a class of integral membrane proteins most commonly associated with action potential propagation in excitable cells. Recent studies have revealed that members of this class are expressed in invasive cell types, such as macrophages and neoplastic cells. In small cell and non-small cell lung cancer, experiments using immunohistology and patch clamp electrophysiology provide evidence for a remarkable relationship between NaV distribution and metastatic potential. Using small molecule fluorophores patterned after the potent NaV inhibitor (+)-saxitoxin, we aim to make possible dynamic imaging of NaV trafficking in live lung cancer cell lines. This strategy will allow us to correlate NaV localization with extracellular matrix degradation and with subcellular structures, such as invadopodia, that are associated with increased cancer cell invasiveness. Through the addition of exogenous modifiers prior to imaging, we will probe specific biochemical pathways that regulate NaV distribution. Insights gained from these experiments could make possible the design of molecular therapeutics that alter NaV trafficking and thereby prevent lung cancer metastasis in vivo.