cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Charge identification of fragments produced in ¹⁶O beam interactions at 200 MeV/n and 400 MeV/n on C and C₂H₄ targets
Creators: name: Galati, G.
name: Boccia, V.
name: Alexandrov, A.
name: Alpat, B.
name: Ambrosi, G.
name: Argirò, S.
name: Barbanera, M.
name: Bartosik, N.
name: Battistoni, G.
name: Bisogni, M. G.
name: Bruni, G.
name: Cavanna, F.
name: Cerello, P.
name: Ciarrocchi, E.
name: Colombi, S.
name: De Gregorio, A.
name: De Lellis, G.
name: Di Crescenzo, A.
name: Di Ruzza, B.
name: Donetti, M.
name: Dong, Y.
name: Durante, M.
name: Faccini, R.
name: Ferrero, V.
name: Finck, C.
name: Fiorina, E.
name: Francesconi, M.
name: Franchini, M.
name: Franciosini, G.
name: Galli, L.
name: Ionica, M.
name: Iuliano, A.
name: Kanxheri, K.
name: Kraan, A. C.
name: La Tessa, C.
name: Lauria, A.
name: Torres, E. Lopez
name: Magi, M.
name: Manna, A.
name: Marafini, M.
name: Massa, M.
name: Massimi, C.
name: Mattei, I.
name: Mengarelli, A.
name: Mereghetti, A.
name: Minniti, T.
name: Moggi, A.
name: Morone, M. C.
name: Morrocchi, M.
name: Muraro, S.
name: Pastrone, N.
name: Patera, V.
name: Pennazio, F.
name: Peverini, F.
name: Placidi, P.
name: Pullia, M.
name: Ramello, L.
name: Reidel, C.
name: Ridolfi, R.
name: Salvi, L.
name: Sanelli, C.
name: Sarti, A.
name: Sato, O.
name: Savazzi, S.
name: Scavarda, L.
name: Schiavi, A.
name: Schuy, C.
name: Scifoni, E.
name: Sciubba, A.
name: Servoli, L.
name: Silvestre, G.
name: Sitta, M.
name: Spighi, R.
name: Spiriti, E.
name: Tioukov, V.
name: Tomassini, S.
name: Tommasino, F.
name: Toppi, M.
name: Traini, G.
name: Trigilio, A.
name: Ubaldi, G.
name: Valetti, A.
name: Vanstalle, M.
name: Villa, M.
name: Weber, U.
name: Zarrella, R.
name: Zoccoli, A.
name: Montesi, M. C.
Publisher: name: Frontiers Media S.A.
Year: 2024

description: Introduction: Charged Particle Therapy plays a key role in the treatment of deep-seated tumours, because of the advantageous energy deposition culminating in the Bragg peak. However, knowledge of the dose delivered in the entrance channel is limited by the lack of data on the beam and fragmentation of the target.
 
Methods: The FOOT experiment has been designed to measure the cross sections of the nuclear fragmentation of projectile and target with two different detectors: an electronic setup for the identification of Z ≥ 3 fragments and a nuclear emulsion spectrometer for Z ≤ 3 fragments. In this paper, we analyze the data taken by exposing four nuclear emulsion spectrometers, with C and C₂H₄ targets, to 200 MeV/n and 400 MeV/n oxygen beams at GSI Helmholtzzentrum für Schwerionenforschung (Darmstadt, Germany), and we report the charge identification of produced fragments based on the controlled fading induced on nuclear emulsion films.
 
Results: The goal of identifying fragments as heavy as lithium has been achieved.
 
Discussion: The results will contribute to a better understanding of the nuclear fragmentation process in charged particle therapy and have implications for refining treatment planning in the presence of deep-seated tumors.
Efficacy, Safety and Pharmacokinetics of Once-Daily Saquinavir Soft-Gelatin Capsule/Ritonavir in Antiretroviral-Naive, HIV-Infected Patients
Creators: name: Julio, Montaner S
name: Schutz, Malte
name: Schwartz, Robert
name: Jayaweera, Dushyantha T
name: Burnside, Alfred F
name: Walmsley, Sharon
name: Saag, Michael S
Publisher: name: BioMed Central
Year: 2016

description: Context: Once-daily HIV treatment regimens are being used in clinical practice with the objective of improving patient acceptance and adherence. Objective: To evaluate the efficacy and safety of saquinavir-soft-gelatin capsule (SGC)/ritonavir combination (1600 mg/100 mg) vs efavirenz (600 mg) both once daily and combined with 2 nucleoside analogs twice daily. Setting: Twenty-six centers in the United States, Canada, and Puerto Rico. Patients: A total of 171 antiretroviral naive HIV-infected individuals were enrolled in a 48-week, phase 3, open-label, randomized study. Main Outcome Measure: Proportion of patients with HIV-RNA levels < 50 copies/mL. The pharmacokinetic profile of saquinavir-SGC was analyzed in a subset of randomly selected patients. Results: In the primary intent-to-treat population at week 48, 51% (38/75) and 71% (55/77) of patients in the saquinavir-SGC/ritonavir and efavirenz groups, respectively, achieved HIV-RNA suppression < 50 copies/mL (P =.5392, 95% 1-sided confidence interval [CI] = -33.5%). In the on-treatment (OT) population, 73% (38/52) and 93% (54/58) of patients in the saquinavir-SGC/ritonavir and efavirenz groups, respectively, had effective viral suppression < 50 copies/mL (P =.5015, 95% 1-sided CI = -33.4%). Mean CD4+ cell counts increased by 239 and 204 cells/microliters (mcL), in the saquinavir-SGC/ritonavir and efavirenz groups, respectively, in the OT analysis (P =.058). Both regimens were reasonably well tolerated, although more gastrointestinal adverse events were reported with saquinavir-SGC/ritonavir. Pharmacokinetic profiles in 6 patients showed an observed median Cmin at 24 hours of 429 ng/mL (range, 68-1750 ng/mL). Conclusion: Once-daily efavirenz was statistically superior to once-daily saquinavir-SGC/ritonavir. Gastrointestinal adverse effects were commonly associated with treatment failure in the saquinavir-SGC/ritonavir arm of the study.
Additional file 3 of OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning
Creators: name: Schmied, Christopher
name: Ebner, Michael
name: Samsó, Paula
name: Van Der Veen, Rozemarijn
name: Haucke, Volker
name: Lehmann, Martin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Additional file 3. Figures S1-S6. Fig. S1: Measuring the distance of individual organelles from the nucleus is robust to changes in cell size regardless of cell shape but performs weakly with sheet-like organelles. Fig. S2: Segmentation and measurement versatility of OrgaMapper. Fig. S3: Impact of optical resolution, detection parameters, and organelle shape on spot detection quality. Fig. S4. Analysis modality selection based on organelle morphology and quantitative comparison of detection methods. Fig. S5: OrgaMapper analysis is robust to organelle swelling.Fig. S6: OrgaMapper workflow diagram of main modules.
Markers of exacerbation severity in chronic obstructive pulmonary disease
Creators: name: Franciosi, Luigi G
name: Page, Clive P
name: Celli, Bartolome R
name: Cazzola, Mario
name: Walker, Michael J
name: Danhof, Meindert
name: Rabe, Klaus F
name: Pasqua, E D O
Publisher: name: BioMed Central
Year: 2016

description: Background: Patients with chronic obstructive pulmonary disease (COPD) can experience 'exacerbations' of their conditions. An exacerbation is an event defined in terms of subjective descriptors or symptoms, namely dyspnoea, cough and sputum that worsen sufficiently to warrant a change in medical management. There is a need for reliable markers that reflect the pathological mechanisms that underlie exacerbation severity and that can be used as a surrogate to assess treatment effects in clinical studies. Little is known as to how existing study variables and suggested markers change in both the stable and exacerbation phases of COPD. In an attempt to find the best surrogates for exacerbations, we have reviewed the literature to identify which of these markers change in a consistent manner with the severity of the exacerbation event. Methods: We have searched standard databases between 1966 to July 2004 using major keywords and terms. Studies that provided demographics, spirometry, potential markers, and clear eligibility criteria were included in this study. Central tendencies and dispersions for all the variables and markers reported and collected by us were first tabulated according to sample size and ATS/ERS 2004 Exacerbation Severity Levels I to III criteria. Due to the possible similarity of patients in Levels II and III, the data was also redefined into categories of exacerbations, namely out-patient (Level I) and in-patient (Levels II & III combined). For both approaches, we performed a fixed effect meta-analysis on each of the reported variables. Results: We included a total of 268 studies reported between 1979 to July 2004. These studies investigated 142,407 patients with COPD. Arterial carbon dioxide tension and breathing rate were statistically different between all levels of exacerbation severity and between in out- and in-patient settings. Most other measures showed weak relationships with either level or setting, or they had insufficient data to permit meta-analysis. Conclusion: Arterial carbon dioxide and breathing rate varied in a consistent manner with exacerbation severity and patient setting. Many other measures showed weak correlations that should be further explored in future longitudinal studies or assessed using suggested mathematical modelling techniques.
Hans Martin Krämer, Tino Schölz, Sebastian Conrad (Hg.): Geschichtswissenschaft in Japan. Themen, Ansätze und Theorien
Creators: name: Vollmer, Klaus
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 106 (2008): ASIEN (Januar)
A strategy to achieve development through research based on local perceptions in Riberalta, Bolivia
Creators: name: Haffenden, Austin
Publisher: name: figshare
Year: 2012
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Anthropology

description: This investigation was realised over 9 weeks in Riberalta, Beni, in the Northern
Bolivian Amazon. Interviews and group exercises were carried out in local communities
(Palmira, 26 de Octubre, Warnes, 7 de Julio, Santa Maria, Berlin and Popechi) and with
local practitioners; primarily with the workers from the three teams (Agroforestry,
Forestry and Social) of IPHAE, but also with personnel from ForLive and PROMAB
the constituent parts of the Instituto de Investigaciones Forestales de la Amazonía
(IIFA).
An examination of recidivism in a population of Canadian sex offenders
Creators: name: Wexler, Audrey F
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Psychology, Behavioral.
subject: Sociology, Criminology and Penology.

description: This study examined estimates and predictors of recidivism of 587 convicted male sex offenders who had been assessed at the Sexual Behaviors Clinic (SBC) and who were followed over a 20 year period. Subjects were grouped into three broad categories based on the index offense: (1) 85 offenders against female adults (rapists); (2) 206 extrafamilial child molesters (CM); and (3) 295 incest offenders. Demographic information, historical variables, characteristics of the index offence, and clinical information were collected from medical records. Offense data were collected from Canadian Police Information Center (CPIC) records. The percentage of rapists, CM, and incest offenders who re-offended sexually over the 20 year period was 24.4, 22.8, and 9.8, respectively. The percentage of rapist, CM, and incest offenders that recidivated violently was 37.2, 34.0, and, 20.0, respectively. The percentage of rapists, CM, and incest offenders that committed any new offense was 56.4, and 46.1, 27.5, respectively. The CM group appeared to take the longest to re-offend sexually and violently, and seemed to be at greatest risk to reoffend 10 to 15 years following release. Offenders who committed a new sexual offence, new violent offence, or any new offence were differentiated by means of univariate analyses. Age of offender, historical criminal factors (e.g., age at first offense, history of prior offenses), and scores on the Psychopathy Checklist-Revised repeatedly differentiated between recidivists and non-recidivists. Stepwise logistic regression analysis assessed which factors were useful in predicting sexual recidivism and violent recidivism. Sexual recidivism among rapists was best predicted by never being married at time of assessment and the presence of historical charges, whereas violent recidivism was best predicted by marital status, childhood history, historical criminal charges, and psychopathy. Sexual recidivism among CM was predicted by the number of years of education, high level of force during the initial offence, arousal to deviant and violent activities with children, historical offences, and psychopathy. Violent recidivism was predicted by the age of the offender at the time of assessment, years of education, historical offences, and psychopathy. Sexual recidivism among the incest group was predicted by the offender's age, an index of his alcohol use during his index offence, and the degree of psychopathy. Violent recidivism was predicted by the combination of the offender's age, family history of alcoholism, alcohol use at time of index offence, age when criminal history began, general alcohol use, and psychopathy. Implications of findings and suggestions for future directions of sex offender research are presented.
Methods for quantitative assessment of seismic risk of linear structures (on the example of the Angren-Pop trnsport artery)
Creators: name: Mansurov Azizjon Farkhod ugli . Oripov Nozimjon Komilovich
Publisher: name: Zenodo
Year: 2024

description: Annotation

The article provides information on the methods of quantitative assessment of the seismic risk of the area where the Angren-Pop transport artery is located, and based on the results of the conducted scientific research, the last 10 years of data on the area under study is collected. Therefore, the engineering-geodynamic (dangerous-geological) processes associated with the Pamir-Hindukush earthquakes between 2012-2022 and the economic damage caused by them were assessed.

Keywords: Seismic risk, seismic vulnerability, tectonic disturbances, grunts.
Pioneer species ecology: co-existence and ecological differences amongst contrasting species
Creators: name: Haffenden, Austin
Publisher: name: figshare
Year: 2012
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Ecological differences were investigated for two co-existing pioneer species from the Cecropia family for variation of first branch height and canopy width across old field and old-growth forest habitats and within habitat variation between species. Forest enumeration data was collected, on all trees >5 cm DBH, from 4 study sites, each containing 9 old-growth forest and 4 old field plots, within the Los Cedros reserve, Ecuador. Cecropia species 1 was not locally more abundant but was found to be more spatially distributed at 32 of the 52 plots; Cecropia sp. 2 was only present at 7 of the 52 plots. Coefficients of variation and allometric relationships were investigated within species and between habitats. No significant variation was found for either species between habitats. For investigations of first branch height Cecropia species 1 was significantly lower than Cecropia sp. 2 in comparisons of actual first branch height (old-growth forest, p
"A better place to live": National mythologies, Canadian history textbooks, and the reproduction of white supremacy
Creators: name: Montgomery, Kenneth Edward
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Black Studies.
subject: Canadian Studies.
subject: Education, Social Sciences.

description: This thesis examines how high school Canadian history textbooks authorized for use in Ontario from 1945 to the present have represented knowledge about race, racism, and opposition to racism in relation to the nation and national identity. Through a Foucault-informed critical discourse analysis, the thesis documents how racism permeates the taken-for-granted structures of schooling, how the imagined community of Canada is reproduced, and how ideas about the nation, race, racism, and opposition to racism are put into cultural circulation as normalized regimes of truth. My findings can be summarized briefly as follows: (1) Canadian history textbooks continue to circulate the 18th century idea that humanity is divided into sets of biological or naturally occurring races, in spite of it having been recognized for some time that races are social constructions, not facts of nature; (2) Racism has consistently been reduced to irrational, abnormal, extreme, and individualized problems of psychological or moral deficit and represented as either foreign to Canada, isolated incidents within Canada, or part of a distant past and with consequences solely for the racially subjugated; and (3) Opposition to racism has been represented in these textbooks as a state-driven enterprise stressing tolerance of the Other and privileging the idea that racism can be eradicated or stopped wherever it is seen to start. I argue, moreover, that the circulation of this knowledge about race, racism, and opposition to racism helps to prop up particular nationalist mythologies, most notably the myth of Canada as a uniquely tolerant and pluralistic nation-state which has effectively resolved the problem of racism. The effect is to depict Canada as a 'better place to live,' a model for other nations to emulate, and a place with a moral responsibility to uplift apparently inferior places in the world. I conclude by discussing how the institutionalized arrogance necessary to represent Canada as a space of vanquished racism or as a place of antiracist achievement perpetuates mythologies of white settler benevolence as it at once obscures the banal racisms upon which the modern nation-state is built and re-built.
Additional file 1 of Weighted metrics are required when evaluating the performance of prediction models in nested case–control studies
Creators: name: Rentroia-Pacheco, Barbara
name: Bellomo, Domenico
name: Lakeman, Inge M. M.
name: Wakkee, Marlies
name: Hollestein, Loes M.
name: van Klaveren, David
Publisher: name: figshare
Year: 2024
Subjects: Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy

description: Supplementary Material 1.
Points quantiques sur substrat d'indium phosphure: Plate-forme pour des composantes optoélectroniques accordables
Creators: name: Allen, Claudine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Physics, Condensed Matter.

description: InAs/InGaAsP quantum dots were embedded in laser diode structures grown on (100) InP and tunable lasing has been observed between 1.5 mum and 1.7 mum. We first investigated the dynamics of charge carriers and photons in these laser diodes. It was found that the carriers confined in the quantum dots have discrete energy states like those of a bidimensional harmonic oscillator. The interaction between charge carriers and electromagnetic waves was analyzed through the electrical susceptibility. This has confirmed the possibility of wave amplification if the charge carrier population in the quantum dots is inverted, eventually leading to lasing if enough current is injected. Next, we have studied experimentally three different laser diode structures; their spectral properties and their super linear relation between emitted optical power and injected current demonstrate lasing characteristics. The best optoelectronic performance was obtained for the structure with the deepest charge carrier confinement potential and largest density of quantum dots, but an increase of this second parameter doesn't guarantee an improvement of the performance. At room temperature, a laser threshold current density of 1.1 kA/cm 2 and an external quantum differential efficiency of 9.4% have been measured for this laser diode structure as well as a good internal quantum efficiency of 25% approximately. This efficiency decrease from internal to external was attributed to high internal photon losses with a coefficient of 28 cm-1. Typical increase of the threshold current density with temperature was verified with characteristic temperatures between 52 K and 121 K, but this characteristic temperature abnormally increased above 180 K for two of the three laser diode structures. Spectral tuning potential was assessed by studying the effect of temperature and length of the laser diodes on their lasing wavelength. Promising results incited us to set up an external cavity tunable laser based on our quantum dot laser diodes. A tuning range of 110 nm centered at 1580 nm was reached in a spectral region important for applications of optoelectronic devices in the field of telecommunications.
Additional file 1 of Natural plant polyphenols contribute to the ecological and healthy swine production
Creators: name: Mei, Huadi
name: Li, Yuanfei
name: Wu, Shusong
name: He, Jianhua
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1 Applications of polyphenols in swine production.
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
Creators: name: Wallace, Alison M
name: He, Jian-Qing
name: Burkett, Kelly M
name: Ruan, Jian
name: Connett, John E
name: Anthonisen, Nicholas R
name: Paré, Peter D
name: Sandford, Andrew J
Publisher: name: BioMed Central
Year: 2015

description: Background. Alpha-defensins, which are major constituents of neutrophil azurophilic granules, and beta-defensins, which are expressed in airway epithelial cells, could contribute to the pathogenesis of chronic obstructive pulmonary disease by amplifying cigarette smoke-induced and infection-induced inflammatory reactions leading to lung injury. In Japanese and Chinese populations, two different beta-defensin-1 polymorphisms have been associated with chronic obstructive pulmonary disease phenotypes. We conducted population-based association studies to test whether alpha-defensin and beta-defensin polymorphisms influenced smokers' susceptibility to lung function decline and susceptibility to lower respiratory infection in two groups of white participants in the Lung Health Study (275 = fast decline in lung function and 304 = no decline in lung function). Methods Subjects were genotyped for the alpha-defensin-1/alpha-defensin-3 copy number polymorphism and four beta-defensin-1 polymorphisms (G-20A, C-44G, G-52A and Val38Ile). Results There were no associations between individual polymorphisms or imputed haplotypes and rate of decline in lung function or susceptibility to infection. Conclusion These findings suggest that, in a white population, the defensin polymorphisms tested may not be of importance in determining who develops abnormally rapid lung function decline or is susceptible to developing lower respiratory infections.
Additional file 1 of Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Creators: name: Barone, Ludovica
name: Cucchiara, Martina
name: Palano, Maria Teresa
name: Bassani, Barbara
name: Gallazzi, Matteo
name: Rossi, Federica
name: Raspanti, Mario
name: Zecca, Piero Antonio
name: De Antoni, Gianluca
name: Pagiatakis, Christina
name: Papait, Roberto
name: Bernardini, Giovanni
name: Bruno, Antonino
name: Gornati, Rosalba
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Additional file 1: Table S1: Sequences of primers used for qPCR analysis. List of the primers and related gene sequences, used in the manuscript.
Esther Heidbüchel, Johannes Herrmann: The West Papua Conflict in Indonesia: Actors, Issues and Approaches
Creators: name: Werner, Jenni
name: Ziegenhain, Patrick
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 106 (2008): ASIEN (Januar)
Stochastic simulation of HIV epidemic
Creators: name: Landtsheer, Sébastien De
Publisher: name: figshare
Year: 2012
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: This is my masters thesis report, in which I model the HIV epidemic in Luxembourg with a high-level, realistic, stochastic simulation and make predictions for the future under different assumptions.
title: ÐÐ»ÑÐ±Ð¾Ð¼ Ð¿ÑÐµÐ·ÐµÐ½ÑÐ°ÑÐ¸Ð¹ Ðº Ð»ÐµÐºÑÐ¸ÑÐ¼ Ð¿Ð¾ ÐºÑÑÑÑ Â«ÐÐ·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð»ÐµÐ¹ Ñ Ð¶Ð¸Ð²ÑÐ¼Ð¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð°Ð¼Ð¸Â». Ð§Ð°ÑÑÑ 1: ÐÐ¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐ¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸ Ð¸Ñ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð½Ð° Ð±Ð¸Ð¾Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ Ð¸ ÐºÐ»ÐµÑÐºÐ¸. Ð§. 1, ÐÐ¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐ¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸ Ð¸Ñ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð½Ð° Ð±Ð¸Ð¾Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ Ð¸ ÐºÐ»ÐµÑÐºÐ¸
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÑÑÐ¸Ð¿Ð¾Ð², ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐÐ¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐ¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ
Ð­Ð»ÐµÐºÑÑÐ¾Ð¼Ð°Ð³Ð½Ð¸ÑÐ½Ð¾Ðµ Ð¿Ð¾Ð»Ðµ
ÑÐ°Ð´Ð¸Ð¾Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð¿ÑÑÐ¼Ð¾Ðµ Ð¸ Ð½ÐµÐ¿ÑÑÐ¼Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ð¹
ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ·Ð¾Ð²

description: Ð ÑÑÐµÐ±Ð½Ð¾Ð¼ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð¿Ð¾Ð½ÑÑÐ¸Ñ, ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ð¸ Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð», Ð¾ÑÐ½Ð¾ÑÑÑÐ¸ÐµÑÑ Ðº Ð¿ÐµÑÐ²Ð¾Ð¹ ÑÐ°ÑÑÐ¸ ÐºÑÑÑÐ° Â«ÐÐ·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð¾Ð»ÐµÐ¹ Ñ Ð¶Ð¸Ð²ÑÐ¼Ð¸ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð°Ð¼Ð¸Â», ÑÐ°Ð·Ð´ÐµÐ» Â«ÐÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¸Ð¾Ð½Ð¸Ð·Ð¸ÑÑÑÑÐ¸Ñ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ð¹ Ð½Ð° Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾Ð±ÑÐµÐºÑÑÂ», Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÐµ Ð² ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ð¸ Ñ Ð´ÐµÐ¹ÑÑÐ²ÑÑÑÐ¸Ð¼Ð¸ Ð² Ð¡ÐÐ±ÐÐ£ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½ÑÐ¼Ð¸ ÑÑÐ°Ð½Ð´Ð°ÑÑÐ°Ð¼Ð¸. Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð¸Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð», ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¼Ð¾Ð¶ÐµÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑÑÑ ÑÑÑÐ´ÐµÐ½ÑÐ°Ð¼Ð¸ Ð¿ÑÐ¸ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐµ Ðº Ð·Ð°ÑÐµÑÑ Ð¿Ð¾ ÑÐºÐ°Ð·Ð°Ð½Ð½Ð¾Ð¼Ñ ÐºÑÑÑÑ.
Molecular mechanisms in the regulation of B7-1 and B7-2 co-stimulatory molecules in human monocytic cells
Creators: name: Lim, Wilfred Tan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Molecular.

description: The engagement of CD28 receptor with the B7-1 or B7-2 ligands on antigen presenting cells, provide the critical second co-stimulatory signal for the immune activation of T lymphocytes. The molecular mechanisms by' which B7-1 or B7-2 expressions are regulated are not well understood. I investigated the role of mitogen-activated protein (MAPKs) in the regulation of lipopolysaccharide (LPS)-induced B7-1 expression in human monocytes and the promonocytic THP-1 cells. My results show that LPS-induced B7-1 expression in monocytic cells did not involve the activation of either p38 or ERK kinases. By employing JNK inhibitors SP600125, dexamethasone and curcumin that inhibit JNK activation, LPS-induced B7-1 expression was determined to be regulated by JNK MAPKs in both monocytes and THP-1 cells. Also, I identified a distinct B7-1 regulatory element corresponding to the interferon regulatory factor-7 (IRF-7) binding site on the B7-1 promoter, responsible for the regulation of LPS-induced B7-1 transcription. Furthermore, SP600125 and dexamethasone inhibited LPS-induced IRF-7 activity as determined by the luciferase reporter and gel shift assays. Taken together, the results suggest that LPS-induced B7-1 transcription in human monocytic cells may be regulated by IRF-7 transcription factor through JNK MAPKs activation. I also studied the role of MAP kinases in the regulation of B7-2 expression in LPS stimulated human monocytic cells. LPS stimulation of human monocytes resulted in the down-regulation of B7-2 expression that could be abrogated by anti-IL-10 antibodies. My results reveal the distinct involvement of p38 in IL-10 dependent, and JNK in 1L-10independent regulation of B7-2 expression in LPS-stimulated monocytic cells. In addition, by deletion and mutant B7-2 promoter/luciferase gene analysis I identified 3 positive regulatory elements on the B7-2 promoter, NF-kappaB, IRF-2, and an unidentified binding site region that operate cooperatively to control B7-2 expression. Elucidating the signal pathway and molecular mechanisms in the regulation of B7-1 and B7-2 in antigen presenting cells is important as it could provide us with a better understanding of the molecular basis for CD28/B7 co-stimulation. This in turn, may lead to the development of strategies in treating autoimmune diseases, organ transplantation rejections, graft-versus-host disease, infections, and cancer.
Relationship between muscle strength, physical performance, quality of life and bone mineral density among postmenopausal women at risk of osteoporotic fractures
Creators: name: Siew Kuan Chua
name: Singh, Devinder Kaur Ajit
name: Khairunisa Zubir
name: Chua, Yin Yian
name: Rajaratnam, Bala S
name: Sabarul Afian Mokhtar
Publisher: name: Silpakorn University Research, Innovation and Creativity Administration Office
Year: 2020
Subjects: muscle strength
osteoporotic fracture
physical performance
postmenopausal women
quality of life

description: Science, Engineering and Health Studies, 14, 1, 8-21
Predicting outbreaks: a spatial risk assessment of West Nile virus in British Columbia
Creators: name: Tachiiri, Kaoru
name: Klinkenberg, Brian, 1954-
name: Mak, Sunny
name: Kazmi, Jamil
Publisher: name: BioMed Central
Year: 2016

description: Background: West Nile virus (WNv) has recently emerged as a health threat to the North American population. After the initial disease outbreak in New York City in 1999, WNv has spread widely and quickly across North America to every contiguous American state and Canadian province, with the exceptions of British Columbia (BC), Prince Edward Island and Newfoundland. In this study we develop models of mosquito population dynamics for Culex tarsalis and C. pipiens, and create a spatial risk assessment of WNv prior to its arrival in BC by creating a raster-based mosquito abundance model using basic geographic and temperature data. Among the parameters included in the model are spatial factors determined from the locations of BC Centre for Disease Control mosquito traps (e.g., distance of the trap from the closest wetland or lake), while other parameters were obtained from the literature. Factors not considered in the current assessment but which could influence the results are also discussed. Results: Since the model performs much better for C. tarsalis than for C. pipiens, the risk assessment is carried out using the output of C. tarsalis model. The result of the spatially-explicit mosquito abundance model indicates that the Okanagan Valley, the Thompson Region, Greater Vancouver, the Fraser Valley and southeastern Vancouver Island have the highest potential abundance of the mosquitoes. After including human population data, Greater Vancouver, due to its high population density, increases in significance relative to the other areas. Conclusion: Creating a raster-based mosquito abundance map enabled us to quantitatively evaluate WNv risk throughout BC and to identify the areas of greatest potential risk, prior to WNv introduction. In producing the map important gaps in our knowledge related to mosquito ecology in BC were identified, as well, it became evident that increased efforts in bird and mosquito surveillance are required if more accurate models and maps are to be produced. Access to real time climatic data is the key for developing a real time early warning system for forecasting vector borne disease outbreaks, while including social factors is important when producing a detailed assessment in urban areas.
Income inequality and its effects on access to ecological services in a western US city (IGC2012, abstract PDF)
Creators: name: Katti, Madhusudan
name: Jones, Andrew Rhys
name: Kaberi Kar Gupta
Publisher: name: figshare
Year: 2012
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Geography
subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: This is the abstract of a talk in a symposium on "Urban dynamics and environmental conflicts" held on 28 Aug 2012 in the International Geographical Congress 2012 in Köln, Germany. Slides from the full presentation are also available here in PDF form.
Selenium nanoparticles biosynthesized by garlic extract as antimicrobial agent
Creators: name: Pinprapha Sribenjarat
name: Nuananong Jirakanjanakit
name: Kalyanee Jirasripongpun
Publisher: name: Silpakorn University Research, Innovation and Creativity Administration Office
Year: 2020
Subjects: selenium nanoparticles
garlic
antibacterial
Staphylococcus aureus
cytotoxicit

description: Science, Engineering and Health Studies, 14, 1, 22-31
Application of density functional theory to large systems: Implementation of the continuous fast multipole method and investigation of models of pentacoordinate phosphorus
Creators: name: Shaw, Michelle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Chemistry, General.

description: The density functional package DeFT is used for systems with a large number of charge distributions, and the bottleneck of the computation is the evaluation of two-electron integrals. Previously, it scaled quadratically with system size. A particular strategy, called the continuous fast multipole method, has been implemented in DeFT and combined with traditional methods for evaluating the two-electron integrals. The result is a code which scales linearly with system size and is able to treat larger systems. The Continuous Fast Multipole Method (CFMM) uses the divide-and-conquer strategy to approximate the pairwise potentials between continuous charge distributions. Pairwise potentials are computed using the direct method if they are within a defined distance of one another; and are approximated by a multipolar expansion if they are not. The algorithm involves successive subdivisions of the simulation space until the desired precision is reached, which reduces the number of pairwise potentials evaluated. For large systems, this algorithm scales linearly with the number of charge distributions. Enzyme-catalyzed phosphoryl transfer reactions have many applications in biological systems. It has been shown in previous investigations that phosphoryl transfer in enzymes proceeds via a pentacoordinate phosphorus intermediate. Few theoretical investigations have been conducted on this class of enzymes due to the large number of atoms treated quantum mechanically. In this investigation, models of the pentacoordinate phosphorus intermediate are investigated with density functional methods. Comparison of the results of calculations using the VSXC functional with experiment and perturbation theory are employed to validate its use in investigations of phosphoryl transfer reactions.
Qualified youth workers for Europe - A manual for the recognition of competences
Creators: name: Krämer-Erklavec, Hanna
name: Schreiner, Klaus
name: Strutzenberger-Reiter, Edda
name: Riechert, Theresa
name: Brauckmann, Anna
name: Nick, Peter
name: Jung, Micha
Publisher: name: Zenodo
Year: 2020
Subjects: Youth Work
recognition of competences
competences
formal learning
informal learning
non-formal learning
National Qualifications Framework
NQF
European Qualifications Framework
EQF
learning outcome

description: This guide deals with the issue of the recognition of competences of youth workers in the political and european context and presents two concrete practical examples: the aufZAQ Competence Framework for Youth Work and the Qualifications Profile for Youth Work developed at the JumP project at University of Applied Sciences Kempten. The guide thus works as a quality development tool for training and further education for youth workers. In this sense, it contributes to the transparency of their competences and their recognition and provides an overview of the relevant expert discourse. For this purpose, the findings of formal academic qualification for youth work are linked to those from the non-formal sector. Valuable perspectives for future qualifications and recognition projects can thus be developed.

 This guide consists of three parts:
 Part 1 "Qualified youth workers for Europe - A manual for the recognition of competences:
 The information section shows the relevance of recognition and transparency of competences of youth workers. It provides an insight into the discourse that forms the background for this guide. This part defines basic terms. It addresses the constitution of recognition and the political developments that go along with it. An overview of existing options for recognition of competences then leads to the two competence models.

 Part 2 "aufZAQ Competence Framework for Youth Work - An Overview":
 The second part provides an overview of the model aufZAQ Competence Framework for Youth Work. This enables the classification of competences in youth work at levels II to VI of the European Qualifications Framework (EQF). In addition, this section describes the scientific approach for the development of the aufZAQ Competence Framework.

 Part 3 "Qualifications Profile for Youth Work Competence Requirements of full-time Professionals in Youth Work":
 The third part presents the Qualifications Profile for Youth Work. It is a competence model for full-time professionals in youth work. It is also based on the European Qualifications Framework (EQF) and makes acquired competences available for the higher education sector – and thus for formal education. It also encourages reflection and discussion of the professional self-understanding of fulltime professionals in youth work.

 www.aufZAQ.at
 www.hs-kempten.de/JumP
Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure
Creators: name: Singhera, Gurpreet K
name: Chan, Tiffany S
name: Cheng, Jenny Y
name: Vitalis, Timothy Z
name: Hamann, Kimm J
name: Dorscheid, Delbert R
Publisher: name: BioMed Central
Year: 2015

description: Background: Effects of respiratory viral infection on airway epithelium include airway hyper-responsiveness and inflammation. Both features may contribute to the development of asthma. Excessive damage and loss of epithelial cells are characteristic in asthma and may result from viral infection. Objective: To investigate apoptosis in Adenoviral-infected Guinea pigs and determine the role of death receptor and ligand expression in the airway epithelial response to limit viral infection. Methods: Animal models included both an Acute and a Chronic Adeno-infection with ovalbumin-induced airway inflammation with/without corticosteroid treatment. Isolated airway epithelial cells were cultured to study viral production after infection under similar conditions. Immunohistochemistry, western blots and viral DNA detection were used to assess apoptosis, death receptor and TRAIL expression and viral release. Results: In vivo and in vitro Adeno-infection demonstrated different apoptotic and death receptors (DR) 4 and 5 expression in response to corticosteroid exposure. In the Acute Adeno-infection model, apoptosis and DR4/5 expression was coordinated and were time-dependent. However, in vitro Acute viral infection in the presence of corticosteroids demonstrated delayed apoptosis and prolonged viral particle production. This reduction in apoptosis in Adeno-infected epithelial cells by corticosteroids exposure induced a prolonged virus production via both DR4 and TRAIL protein suppression. In the Chronic model where animals were ovalbumin-sensitized/challenged and were treated with corticosteroids, apoptosis was reduced relative to adenovirus-infected or corticosteroid alone. Conclusion: Our data suggests that apoptosis of infected cells limits viral production and may be mediated by DR4/5 and TRAIL expression. In the Acute model of Adeno-infection, corticosteroid exposure may prolong viral particle production by altering this apoptotic response of the infected cells. This results from decreased DR4 and TRAIL expression. In the Chronic model treated with corticosteroids, a similar decreased apoptosis was observed. This data suggests that DR and TRAIL modulation by corticosteroids may be important in viral infection of airway epithelium. The prolonged virus release in the setting of corticosteroids may result from reduced apoptosis and suppressed DR4/TRAIL expression by the infected cells.
Fate and function of soluble CD14 at ocular and gastrointestinal surfaces and in transgenic tobacco seeds
Creators: name: Blais, David R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Microbiology.
subject: Chemistry, Biochemistry.
subject: Health Sciences, Immunology.

description: Mucosal surfaces are constantly challenged with a variety of microorganisms. The pathogen invasion of mucosal surfaces is initially countered by the innate immune system via recognition of microbe-specific motifs. Of these microbial motifs, lipopolysaccharide (LPS) is known to be one of the most powerful bacterial virulence factors. This thesis is an attempt to understand the roles of the LPS receptor complex at mucosal surfaces and the ways by which it discriminates between commensal and pathogenic Gram-negative bacteria. The LPS receptor components studied were the LPS binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR4) and myeloid differentiation protein 2 (MD-2). In the first section of this thesis, biological analyses of the LPS receptor complex at the tear-corneal interface suggested that the LPS receptor components are strategically and spatially expressed to fine-tune and even restrain their LPS response to invasive pathogenic Gram-negative bacteria. To study its function in the developing gastrointestinal mucosal surface, soluble CD14 in breast milk was tracked in human neonates. The lack of detection of CD14 in stools of breast-fed neonates and the in vitro proteolysis assays suggested that CD14 is likely to survive its gastrointestinal passage in the low bacteria density lumen of the upper digestive system, but is likely to be absent from the LPS-rich environment of the distal gastrointestinal tract. This controlled and limited spatial distribution could be a strategy to prevent an overzealous immune response against the commensal flora of the distal bowel. The results obtained from these two studies concluded that the function and fate of CD14 at mucosal surfaces was dynamic enough to merit further investigations on a much larger scale. For this to happen, recombinant expression systems needed to be first explored. The successful production of human CD14 in transgenic tobacco proved to be a promising source of a stable and active CD14 to further elucidate the mechanisms of the mucosal LPS response system.
Special Economic Zones in India - An Introduction
Creators: name: Dohrmann, Jona Aravind
Publisher: name: Asien
Year: 2021

description: This introductory article describes the salient features of the Indian embodiment of the model Chinese SEZ, how it evolved and what the various steps are in making an Indian SEZ function: from submitting an application and receiving a Letter of Approval for the establishment of an SEZ to getting the authorised operations and particular units sanctioned. The SEZs are tax-free enclaves for investors from India and abroad. As the Prime Minister of India, Dr. Manmohan Singh, said: “SEZs are here to stay”. The Indian government and the state governments are now finding that it is not enough to promulgate modern laws luring foreign direct investment into India, but that they also have to provide for the concerns and the livelihoods of those affected by the establishment of SEZs.
description: Asien, Nr. 106 (2008): ASIEN (Januar)
Labidus Jurine 1807
Creators: name: The, In
name: Esteves, Flávia A.
name: Brandão, Carlos Roberto F.
name: Prado, Lívia P.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Labidus

description: Genus Labidus Jurine
 Labidus nero subsp. denticulatus Borgmeier, 1955: 129. Type [holotype]: 1 m. Type [paratype]: 1 male [Brazil], PA[rá], Serra do Cachimbo, [09°22’S, 54°54’W, 420 m.], ix.1953, H. Sick leg. Holotype: Genitalia dissociated, disarticulated left forewing.
 Eciton (Labidus) caecum st. servillei var. hostilis Santschi, 1920: 368. Cotype [syntype]: 1 m. French Guiana, Nouveau Chantier, coll. Le Moult. Missing head, genitalia dissociated [Unavailable name, material referred to Labidus coecus Latreille, 1802 by Borgmeier, 1953: 14 (Bolton, 1995)].
 Eciton (Labidus) coecum st. nero Santschi, 1930: 82. Syntype: 1 m. [Brazil, Rio de Janeiro,] Itatiaya [Itatiaia], 15.x.[19]28, J.F. Zikán [original description says Reichensperger leg.]. Combination in Labidus and raised to species: Borgmeier, 1953: 14. See also: Borgmeier, 1955: 127. Junior synonym of Labidus mars Forel: Nascimento et al. 2004: 618.
 Eciton (Labidus) serpentis Weber, 1938: 209. Cotype [syntype]: 1 w. B[ritish] Guiana, Oronoque R [iver], 02°42’, N.A., [1.viii.1936], Weber col., [#] 620. Junior synonym of Labidus coecus Latreille: Borgmeier, 1955: 86.
description: Published as part of The, In, Esteves, Flávia A., Brandão, Carlos Roberto F. & Prado, Lívia P., 2011, The Type Specimens Of " Dorylomorph " Ants (Hymenoptera, Formicidae: Aenictinae, Ecitoninae, Cerapachyinae, Leptanilloidinae) Deposited In The Museu De Zoologia Da Universidade De São Paulo, Brazil, pp. 341-357 in Papéis Avulsos de Zoologia 51 (22) on pages 341-357, DOI: 10.1590/S0031-10492011002200001, http://zenodo.org/record/13222746
More Norfolk palimpsest brasses in the churches of St Mary, Shelton, St Andrew, Honingham, St Mary, Holm-next-the-Sea, All Saints' Woodton, Reedham, and Swardeston
Creators: name: Clark, H O
name: Johnson, Feenagh
name: Rudd, W R
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 22 (1), 59-74