cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Therapeutic effect of E-Lip-siRNA-sFlt1 on pre-eclampsia: targeted gene silencing and improved pregnancy outcomes
Creators: name: Dong, Jinhua
name: Zhang, Yingying
name: Zhou, Jingsheng
name: Mao, Shuhui
name: Tang, Jianfen
name: Li, Suping
name: Ma, Qiang
name: Ai, Ling
name: Wang, Wei
name: Zhu, Guanghao
name: Shao, Huijing
name: Meng, Yingdi
name: Chen, Huaiwen
name: Chen, Danqing
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Aim: To evaluate a liposome complex conjugated with anti-epidermal growth factor receptor (EGFR) antibodies for the treatment of pre-eclampsia (PE). Methods: In in vitro experiments, the transfection rate, silencing effect and cytotoxicity were determined. In the in vivo PE model, the siRNA distribution, mean arterial pressure, 24-h urine protein concentration, serum sFlt1 concentration, number of viable fetuses and placental weight were measured. Results: The nanomedicine effectively reduced the expression of sFIt1 and had a strong ability to target placental tissues. It could significantly reduce the symptoms of pre-eclampsia and improve pregnancy outcomes in PE model rats. Conclusion: The constructed nanomedicine can improve pregnancy outcomes in a rat model of pre-eclampsia and provides a new strategy for the treatment of pre-eclampsia. sFlt1 has been extensively studied and recognized as a key therapeutic target in pre-eclampsia. Treatment of pre-eclampsia using liposome-loaded siRNA-sFlt1 is a potential therapeutic approach that could complement existing treatment modalities. In this study, we evaluated the in-vivo and in-vitro efficacy of siRNA-sFlt1 nanoliposomes coupled with anti-EGFR antibodies for targeting the placenta in the treatment of pre-eclampsia. We used a Malvern particle sizer and TEM to determine that the size of the finished nanoliposomes was approximately 150 nm. After incubation with HTR-8/SVneo cells, the nanocarriers were assembled with fluorescently labeled siRNA-sFlt1, and a greater targeting efficiency of E-Lip-siRNA-sFlt1 was demonstrated by flow cytometry. Measurement of sFlt1 at the nucleic acid and protein levels was performed using qPCR and ELISA kits, respectively, and the results revealed a significant decrease in sFlt1 levels. Compared with the naked nucleic acid and nontargeted groups, the nanoliposome group encapsulating anti-EGFR antibodies showed more accumulation in the placenta. E-Lip-siRNA-sFlt1 improves pregnancy outcomes in a TNF-α-induced pre-eclampsia rat model. E-Lip-siRNA-sFlt1-treated rats in the pre-eclampsia model showed no signs of major organ damage. However, whether there are potential long-term effects on fetal rats that are delivered needs to be further studied. A rigorous evaluation is needed before conducting clinical studies.
Rhapsody-G simulations: galaxy clusters as baryonic closed boxes and the covariance between hot gas and galaxies
Creators: name: Wu, Hao-Yi
name: Evrard, August E.
name: Hahn, Oliver
name: Martizzi, Davide
name: Teyssier, Romain
name: Wechsler, Risa H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Within a sufficiently large cosmic volume, conservation of baryons implies a simple `closed box' view in which the sum of the baryonic components must equal a constant fraction of the total enclosed mass. We present evidence from Rhapsody-G hydrodynamic simulations of massive galaxy clusters that the closed-box expectation may hold to a surprising degree within the interior, non-linear regions of haloes. At a fixed halo mass, we find a significant anti-correlation between hot gas mass fraction and galaxy mass fraction (cold gas + stars), with a rank correlation coefficient of -0.69 within $R_{500c}$. Because of this anti-correlation, the total baryon mass serves as a low-scatter proxy for total cluster mass. The fractional scatter of total baryon fraction scales approximately as $0.02 (Δ_c/100)^{0.6}$, while the scatter of either gas mass or stellar mass is larger in magnitude and declines more slowly with increasing radius. We discuss potential observational tests using cluster samples selected by optical and hot gas properties; the simulations suggest that joint selection on stellar and hot gas has potential to achieve 5% scatter in total halo mass.
description: 10 pages, 6 figures, 3 tables; replaced to match published version
Plasmonics for microwave photonics in the THz range
Creators: name: Burla, Maurizio
name: Hoessbacher, Claudia
name: Heni, Wolfgang
name: Haffner, Christian
name: Salamin, Yannick
name: Fedoryshyn, Yuriy
name: Watanabe, Tatsuhiko
name: Massler, Hermann
name: Blatter, Tobias
name: Horst, Yannik
name: Elder, Delwin L.
name: Dalton, Larry R.
name: Leuthold, Juerg
Publisher: name: Technische Universität Berlin
Year: 2023
Subjects: subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik
subject: microwave photonics
subject: plasmonics
subject: modulators
subject: terahertz
subject: analog links
subject: wireless communications

description: THz frequencies offer enormous amounts of bandwidth, which could solve the current speed bottleneck for next-generation wireless communications. Recent reports show sub-THz links offering capacities of hundreds of Gbit/s, finally approaching those of state-of-the-art optical transmission channels. Non-etheless, generation, transport, detection and processing of signals in the THz range is far from being a trivial task. Even though the recent evolution of integrated technology is starting to indicate that chip-scale THz technology could gradually close the so-called “THz gap,” much work still needs to be done to enable functional systems, in particular in terms of efficiency. Photonics can be of help, thanks to its extremely low loss and broad bandwidth. Yet, a particularly critical aspect hindering the deployment of THz technology is that state-of-the-art photonics devices generally do not offer sufficient electro-optical bandwidth to process THz signals. Plasmonics, by focusing electromagnetic surface waves at sub-wavelength scales, can play a key role in this quest, as it finally enables the realization of electro-optical devices such as modulators and detectors displaying sufficient compactness and speeds to reach the THz range. This paper overviews recent achievements on plasmonic-based modulators displaying characteristics of speed, efficiency and linearity that enable high-performance access to this much desired frequency range.
(502710) ____ [Shafto]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502234) Clementine Matilda [Dodd]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Weak-strong clustering transition in renewing compressible flows
Creators: name: Dhanagare, Ajinkya
name: Musacchio, Stefano
name: Vincenzi, Dario
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We investigate the statistical properties of Lagrangian tracers transported by a time-correlated compressible renewing flow. We show that the preferential sampling of the phase space performed by tracers yields significant differences between the Lagrangian statistics and its Eulerian counterpart. In particular, the effective compressibility experienced by tracers has a non-trivial dependence on the time correlation of the flow. We examine the consequence of this phenomenon on the clustering of tracers, focusing on the transition from the weak- to the strong-clustering regime. We find that the critical compressibility at which the transition occurs is minimum when the time correlation of the flow is of the order of the typical eddy turnover time. Further, we demonstrate that the clustering properties in time-correlated compressible flows are non-universal and are strongly influenced by the spatio-temporal structure of the velocity field.
description: 8 pages, J. Fluid Mech., in press
Archetypes of digital twins
Creators: name: Van Der Valk, Hendrik
name: Möller, Frederik
name: Otto, Boris
name: Haße, Hendrik
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Digital Twin
subject: Archetypes
subject: Dimensions
subject: Characteristics
subject: Cluster analysis
subject: 620
subject: Digitaler Zwilling
subject: Konfiguration
subject: Cluster-Analyse

description: Currently, Digital Twins receive considerable attention from practitioners and in research. A Digital Twin describes a concept that connects physical and virtual objects through a data linkage. However, Digital Twins are highly dependent on their individual use case, which leads to a plethora of Digital Twin configurations. Based on a thorough literature analysis and two interview series with experts from various electrical and mechanical engineering companies, this paper proposes a set of archetypes of Digital Twins for individual use cases. It delimits the Digital Twins from related concepts, e.g., Digital Threads. The paper delivers profound insights into the domain of Digital Twins and, thus, helps the reader to identify the different archetypical patterns.
description: Business & information systems engineering;Bd 64. 2022, 3, S. 375-391
Countering Hesitancy and Misinformation on Side Effects to Complete the Course of COVID Vaccination
Creators: name: Dasgupta, Nabarun
Publisher: name: SAGE Publications
Year: 2021

description: 
It has been well-documented that concerns about side effects prevent many from soliciting immunization. And family medicine providers play a key role in addressing concerns about COVID vaccines. However, there are few documented examples of the decision-making process regarding second shots after the emergence of a concerning and previously unknown side effect. Therefore, we present a case where a primary care provider and patient worked together to analyze real-time adverse event data on post-vaccination shingles to decide whether to receive the second dose.
The 3-Loop Non-Singlet Heavy Flavor Contributions to the Structure Function g_1(x,Q^2) at Large Momentum Transfer
Creators: name: Behring, A.
name: Blümlein, J.
name: De Freitas, A.
name: von Manteuffel, A.
name: Schneider, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We calculate the massive flavor non-singlet Wilson coefficient for the heavy flavor contributions to the polarized structure function $g_1(x,Q^2)$ in the asymptotic region $Q^2 \gg m^2$ to 3-loop order in Quantum Chromodynamics at general values of the Mellin variable $N$ and the momentum fraction $x$, and derive heavy flavor corrections to the Bjorken sum-rule. Numerical results are presented for the charm quark contribution. Results on the structure function $g_2(x,Q^2)$ in the twist-2 approximation are also given.
description: 29 pages, 8 Figures
(502575) Catherine Turnbull
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Spin versus charge noise from Kondo traps
Creators: name: da Silva, Luis G. G. V. Dias
name: de Sousa, Rogerio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Magnetic and charge noise have common microscopic origin in solid state devices, as described by a universal electron trap model. In spite of this common origin, magnetic (spin) and charge noise spectral densities display remarkably different behaviours when many-particle correlations are taken into account, leading to the emergence of the Kondo effect. Our numerical renormalization group results indicate that while spin noise is a universal function of the Kondo temperature, charge noise remains well described by single-particle theory even when the trap is deep in the Kondo regime. This difference survives even in the presence of disorder, showing that noise can be more manageable in devices that are sensitive to magnetic (rather than charge) fluctuations and that the signature of the Kondo effect can be observed in spin noise spectroscopy experiments.
description: 9 pages, 6 figures; To appear in PRB. Revised version: includes derivation of exact sum rules, analytical approximation for the spin noise, and additional details of the NRG calculation
Production of codon-optimized Human papillomavirus type 52 L1 virus-like particles in Pichia pastoris BG10 expression system
Creators: name: Dewi, Kartika Sari
name: Chairunnisa, Sheila
name: Swasthikawati, Sri
name: Yuliawati
name: Agustiyanti, Dian Fitria
name: Mustopa, Apon Zainal
name: Kusharyoto, Wien
name: Ningrum, Ratih Asmana
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Cervical cancer caused by Human papillomavirus (HPV) is one of the most common causes of cancer death in women worldwide. Even though the disease can be avoided by immunization, the expensive price of HPV vaccines makes it hard to be accessed by women in middle-low-income countries. Thus, the development of generic HPV vaccines is needed to address inequalities in life-saving access. This study aimed to develop the HPV52 L1 VLP-based recombinant vaccine using Pichia pastoris expression system. The l1 gene was codon-optimized based on P. pastoris codon usage resulting CAI value of 0.804. The gene was inserted into the pD902 plasmid under the regulation of the AOX1 promoter. The linear plasmid was transformed into P. pastoris BG10 genome and screened in YPD medium containing zeocin antibiotic. Colony of transformant that grown on highest zeocin concentration was characterized by genomic PCR and sequencing. The positive clone was selected and expressed using BMGY/BMMY medium induced with various methanol concentrations. The SDS-PAGE and Western blot analyses showed that 55 kDa L1 protein was successfully expressed using an optimum concentration of 1% methanol. The self-assembly of HPV52 L1 protein was also proven using TEM analysis. Moreover, we also analyzed the B-cell epitope of HPV52 L1 protein based on several criteria, including antigenicity, surface accessibility, flexibility, and hydrophilicity. We assumed that epitope 476GLQARPKLKRPASSAPRTSTKKKKV500 could be developed as an epitope-based vaccine with a neutralizing antibody response toward HPV52 infection. Finally, our study provided the alternative for developing low-cost HPV vaccines, either VLP or epitope-based.
(502677) William Maslen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Relationships between nurses’ experiences of workplace violence, emotional exhaustion and patient safety
Creators: name: Mayer, Celeste
name: Kim, Sinhye
name: Jones, Cheryl B
Publisher: name: SAGE Publications
Year: 2021

description: 
Background
The rising rate of workplace violence in hospitals is a serious concern. While leading organisations recommend implementing interventions to address workplace violence, little is known about the workplace violence relationship between patients and visitors, and how it affects nurses’ emotional exhaustion and their perceptions of patient safety.

Aims
The study’s purpose was to understand the status of workplace violence in hospitals and the relationships between nurses’ experiences of workplace violence, emotional exhaustion, and perceptions of patient safety.

Methods
This cross-sectional analysis used data from a survey conducted at a large academic medical centre using the Agency for Healthcare Research and Quality Hospital Survey on Patient Safety Culture plus additional measures of workplace violence and emotional exhaustion.

Results
Nurses reported more occurrences of verbal violence than physical violence. Nurses’ experiences of workplace violence negatively affect nurses’ emotional exhaustion and patient-safety perceptions. Moreover, nurses’ emotional exhaustion mediated the relationship between verbal abuse and patient-safety perceptions.

Conclusions
Interventions to reduce nurses’ emotional exhaustion and strengthen resilience can mitigate the negative effects of verbal abuse and to some extent the effects of physical violence.
A novel kinetic model for a cocoa waste fermentation to ethanol reaction and its experimental validation
Creators: name: Alvarado-Santos, Eduardo
name: Aguilar-López, Ricardo
name: Neria-González, M. Isabel
name: Romero-Cortés, Teresa
name: Robles-Olvera, Víctor José
name: López-Pérez, Pablo A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: A non-segregated kinetic model is proposed to describe a fermentation process of agro-industrial residues derived via cocoa (mucilage juice) by Pichia kudriavzevii. The novel proposed hybrid model is based on a multiple coupling reaction mechanisms (structured) to describe the kinetics of substrate consumption, biomass, carbon dioxide, and ethanol, coupled to an unstructured model for the activity enzyme. The parameters of the kinetic model are estimated by non-linear least-squares curve fitting using the Marquardt-Levenberg algorithm. In addition, numerical simulations were compared with the experimental data via residual graphs. The effectiveness of the model was statistically evaluated using dimensionless efficiency coefficients under different initial conditions. A global sensitivity analysis was applied (Fisher's information matrix). The experimental results of the batch reactor showed a maximum ethanol concentration of 29 g/L, with a yield of 0.48 g-ethanol/g-glucose and a productivity of 0.30 g/L h. The method determined that the cell formation coefficient and the specific substrate consumption rate (θ1 and θ2) directly influence most of the states of our system. The proposed scheme is particularly suitable to assist in the rational design of cell factory properties or fermentation processes because it can represent the complex biochemistry in more detail and under different initial experimental conditions; the above reveals that the generated model is robust and can be considered for control and optimization purposes.
AI4Life Deliverable D5.3 - First stable BioImage Zoo Model format, software tools, libraries and reference examples
Creators: name: Ouyang, Wei
name: Hartley, Matthew
Publisher: name: Zenodo
Year: 2023
Subjects: AI
Machine learning
Imaging
Life Sciences

description: Horizon Europe funded AI4Life project Deliverable D5.3: First stable BioImage Zoo Model format, software tools, libraries and reference examples
Assessing Spiritual Development: Reflections on Building a Community Measure
Creators: name: Orthner, Dennis K.
Publisher: name: SAGE Publications
Year: 2021

description: Measuring a complex and theologically challenging concept like spiritual formation can be daunting. This article describes a multiyear process and methodology that was used in constructing a measure that demonstrated reasonably high levels of reliability, validity, and useability. The article also describes the many challenges in developing this type of measure and strategies for overcoming those challenges. Reflections on how a measure such as this might be helpful, as well as potentially challenging, to churches and pastors are provided in the closing.
Key findings from the EOSC Association Long Term Data Preservation Task Force
Creators: name: L'Hours, Hervé
name: Wyns, Roxanne
Publisher: name: Zenodo
Year: 2024
Subjects: Long Term Data Preservation
Long Term Data Retention
EOSC-A
EOSC-A Task Force
Open Science

description: From 2022 to 2024 the Long Term Data Preservation Task Force (LTDP-TF) of the European Open Science Cloud (EOSC) Association brought together members, association experts and external contributors from diverse backgrounds across research infrastructures and the digital object management lifecycle to deliver a vision and recommendations for optimal preservation of FAIR digital objects. Through a sequence of meetings, engagements, a contextual overview paper, an open consultation and a final report with recommendations the group identified gaps and proposed actions. The key gap, which impacts the development of essential knowledge about roles and costs, is the uneven distribution of awareness within EOSC and beyond that active preservation requires a long term commitment to data management that must adjust to changing technologies and the changing needs of users. Progress on gap analysis issues included the recognition of the emerging need for more concrete and clearly defined sets of activities and functions for repositories, and the validation of the CoreTrustSeal proposed levels of curation and preservation care. Together these and the recommendations can support a move towards clearer typologies of repositories and their levels of speciality, responsibility, curation and preservation.

The resources provide bite-sized contextual assertions that can be reused by actors at all levels from researchers and practitioners to funders and policy makers. There are clear calls to action that are applicable to a range of actors and that guide a cascade of progress from European, to national to institutional level. The materials address FAIR data, trustworthy digital repositories (TDR), standards, assessment, certification, transparency, sustainability  and future project and network routes to collaboration and progress. Together these provide an insight to infrastructures and institutions seeking to deliver, mature and scale complex services with restrained resources.

Attendees will be provided with insight into the context of this EOSC-A task force and its key findings and about how they can engage with and contribute to follow up initiatives.
(502233) James Dodd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Heuristic for Network Coverage Optimization Applied in Finding Organizational Change Agents
Creators: name: Zak, Blazej
name: Zbieg, Anita
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Authors compare different ways of selecting change agents within network analysis paradigm and propose a new algorithm of doing so. All methods are evaluated against network coverage measure that calculates how many network members can be directly reached by selected nodes. Results from the analysis of organizational network show that compared to other methods the proposed algorithm provides better network coverage, at the same time selecting change agents that are well connected, influential opinion leaders.
description: The 2014 IEEE/ACM European Network Intelligence Conference. IEEE Computer Society, pp. 118-122
Artificial neural network modeling and statistical optimization of medium components to enhance production of exopolysaccharide by Bacillus sp. EPS003
Creators: name: Marimuthu, Sivasankari
name: J, Sharon Mano Pappu
name: Rajendran, Karthikeyan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Microbial Exopolysaccharides (EPS) have a wide range of applications in food, cosmetics, agriculture, pharmaceutical industries, and environmental bioremediation. The present study aims at enhancing the production of EPS from a soil-isolate Bacillus sp. EPS003. Effects of carbon and nitrogen sources and process conditions were evaluated one factor at a time. Box-Behnken design has been used and a 2.5-fold increase in yield is reported after optimizing the most influential parameters sucrose, yeast extract, and peptone as identified by the Plackett-Burman method. An artificial neural network (ANN) with two different topologies (EPS-NN1 and EPS-NN2) was developed. On comparing prediction accuracy, EPS-NN2 formulated as one input layer with four input variables (sucrose, yeast extract, peptone, biomass), a single hidden layer with seven neurons and EPS yield in the output layer showed a high coefficient of determination (R2—0.98) and low error (NRMSE—0.024). This study concludes that the consideration of biomass value has increased the prediction accuracy of the model.
Linking Emergency Medical Services and Emergency Department Data to Improve Overdose Surveillance in North Carolina
Creators: name: Falls, Dennis M.
name: Ising, Amy I.
name: Wolff, Catherine S.
name: Proescholdbell, Scott K.
name: Waller, Anna E.
name: Fernandez, Antonio R.
name: Fix, Jonathan
Publisher: name: SAGE Publications
Year: 2021

description: 

Introduction
Linking emergency medical services (EMS) data to emergency department (ED) data enables assessing the continuum of care and evaluating patient outcomes. We developed novel methods to enhance linkage performance and analysis of EMS and ED data for opioid overdose surveillance in North Carolina.


Methods
We identified data on all EMS encounters in North Carolina during January 1–November 30, 2017, with documented naloxone administration and transportation to the ED. We linked these data with ED visit data in the North Carolina Disease Event Tracking and Epidemiologic Collection Tool. We manually reviewed a subset of data from 12 counties to create a gold standard that informed developing iterative linkage methods using demographic, time, and destination variables. We calculated the proportion of suspected opioid overdose EMS cases that received International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis codes for opioid overdose in the ED.


Results
We identified 12 088 EMS encounters of patients treated with naloxone and transported to the ED. The 12-county subset included 1781 linkage-eligible EMS encounters, with historical linkage of 65.4% (1165 of 1781) and 1.6% false linkages. Through iterative linkage methods, performance improved to 91.0% (1620 of 1781) with 0.1% false linkages. Among statewide EMS encounters with naloxone administration, the linkage improved from 47.1% to 91.1%. We found diagnosis codes for opioid overdose in the ED among 27.2% of statewide linked records.


Practice Implications
Through an iterative linkage approach, EMS–ED data linkage performance improved greatly while reducing the number of false linkages. Improved EMS–ED data linkage quality can enhance surveillance activities, inform emergency response practices, and improve quality of care through evaluating initial patient presentations, field interventions, and ultimate diagnoses.
Development and Application of an Interdisciplinary Rapid Message Testing Model for COVID-19 in North Carolina
Creators: name: Gora Combs, Katherine
name: Rothschild, Allison
name: Lazard, Allison J.
name: Ribisl, Kurt M.
name: Carpenter, Kathryn
name: Davis, C. Hunter
name: Hill, Lauren M.
name: Dasgupta, Nabarun
name: Shelus, Victoria
name: Goldblatt, Allison
name: Drewry, Maura
name: Newman, Emily
name: Bartels, Sophia M.
Publisher: name: SAGE Publications
Year: 2021

description: 

Introduction
From the onset of the COVID-19 pandemic, public health officials have sought to develop evidence-based messages to reduce COVID-19 transmission by communicating key information to media outlets and the public. We describe the development of an interdisciplinary rapid message testing model to quickly create, test, and share messages with public health officials for use in health campaigns and policy briefings.


Methods
An interdisciplinary research team from the University of North Carolina at Chapel Hill assembled in March 2020 to assist the state health department in developing evidence-based messages to influence social distancing behaviors in the state. We developed and iteratively executed a rapid message testing model; the components of the 4-step model were message creation, survey development, survey administration, and analysis and presentation to health department officials. The model was executed 4 times, each during a 7-day period in April and May, and each subsequent survey included new phrasing and/or messaging informed by the previous week’s survey. A total of 917 adults from North Carolina participated in the 4 surveys.


Results
Survey participants rated messages focused on protecting oneself and others higher than messages focused on norms and fear-based approaches. Pairing behaviors with motivations increased participants’ desire to social distance across all themes and subgroups. For example, adding “Protect your grandmother, your neighbor with cancer, and your best friend with asthma,” to messaging received a 0.9-point higher score than the base message, “Stay 6 feet apart from others when out in public.”


Practice Implications
Our model to promote social distancing in North Carolina during the COVID-19 pandemic can be used for rapid, iterative message testing during public health emergencies.
On the use of the theory of dynamical systems for transient problems
Creators: name: Galvanetto, Ugo
name: Magri, Luca
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: This paper is a preliminary work to address the problem of dynamical systems with parameters varying in time. An idea to predict their behaviour is proposed. These systems are called \emph{transient systems}, and are distinguished from \emph{steady systems}, in which parameters are constant. In particular, in steady systems the excitation is either constant (e.g. nought) or periodic with amplitude, frequency and phase angle which do not vary in time. We apply our method to systems which are subjected to a transient excitation, which is neither constant nor periodic. The effect of switching-off and full-transient forces is investigated. The former can be representative of switching-off procedures in machines; the latter can represent earthquake vibrations, wind gusts, etc. acting on a mechanical system. This class of transient systems can be seen as the evolution of an ordinary steady system into another ordinary steady system, for both of which the classical theory of dynamical systems holds. The evolution from a steady system to the other is driven by a transient force, which is regarded as a map between the two steady systems.
description: 7 pages, 9 figures
State-level Citizen Response to COVID-19 Containment Measures in Brazil and Mexico
Creators: name: Dunn, Claire
name: Laterzo, Isabel
Publisher: name: SAGE Publications
Year: 2021

description: 
In Brazil and Mexico, presidents failed to take swift, national action to stop the spread of COVID-19. Instead, the burden of imposing and enforcing public health measures has largely fallen to subnational leaders, resulting in varied approaches within each country and conflicting messaging from elites. We likewise see variation in compliance with social distancing across subnational units. To explain this variation, we contend that citizen responses are driven both by the comprehensiveness of state policies and whether they take cues from national or subnational elites. We hypothesize that support for national and subnational elites, and the nature of the state-level policy response, affect citizen compliance with public health guidelines. In both countries, we find that support for the governor has an interactive relationship with policy response. In Brazil, support for the president is associated with lower compliance. In Mexico, this effect is not present. We argue that these distinct relationships are due to the different cues emerging from each leader.
Supporting the Dynamic Careers of Licensed Practical Nurses: A Strategy to Bolster the Long-Term Care Nurse Workforce
Creators: name: Toles, Mark
name: Jones, Cheryl B.
name: McCollum, Meriel
name: Knafl, George J.
name: Tran, Alberta K.
Publisher: name: SAGE Publications
Year: 2021

description: 
As the U.S. population ages and the demand for long-term care increases, an insufficient number of licensed practical nurses (LPNs) is expected in the nursing workforce. Understanding the characteristics of LPN participation in the workforce is essential to address this challenge. Drawing on the theory of boundaryless careers, the authors examined longitudinal employment data from LPNs in North Carolina and described patterns in LPN licensure and career transitions. Two career patterns were identified: (a) the continuous career, in which LPNs were licensed in 75% or more of the years they were eligible to be licensed and (b) the intermittent career, in which lapses in licensure occurred. Findings indicated that LPNs who made job transitions were more likely to demonstrate continuous careers, as were Black LPNs. These findings suggest the importance of organizational support for LPN career transitions and support for diversity in the LPN workforce.
A Comprehensive Simulation Study of a Liquid-Xe Detector for Contraband Detection
Creators: name: Israelashvili, I.
name: Cortesi, M.
name: Vartsky, D.
name: Arazi, L.
name: Bar, D.
name: Caspi, E. N.
name: Breskin, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Recently, a new detector concept, for combined imaging and spectroscopy of fast-neutrons and gamma was presented. It encompasses a liquid-xenon (LXe) converter-scintillator coupled to a UV-sensitive gaseous Thick Gas Electron Multiplier (THGEM)-based imaging photomultiplier (GPM). In this work we present and discuss the results of a systematic computer-simulation study aiming at optimizing the type and performance of LXe converter. We have evaluated the detector spectral response, detection efficiency and spatial resolution for gamma-rays and neutrons in the energy range of 2-15 MeV for 50 mm thick converters consisting of plain LXe volume and LXe-filled capillaries, of Teflon, Polyethylene or hydrogen-containing Teflon (Tefzel). Neutron detection efficiencies for plain LXe, Teflon-capillaries and Tefzel-capillaries converters were about 20% over the entire energy range. In polyethylene capillaries converters the neutron detection efficiency was about 10% at 2 MeV and increased up to about 20% at 14 MeV. Detection efficiencies of gammas in Teflon, Tefzel and polyethylene converters were ~35%. The plain-LXe converter provided the highest gamma-ray detection efficiency, of ~40-50% for 2-15 MeV energy range. Optimization of LXe-filled Tefzel capillary dimensions resulted in spatial resolution of ~1.5mm (FWHM) for neutrons and up to 3.5 mm (FWHM) for gamma-rays. Simulations of radiographic images of various materials using two discrete energy gamma-rays (4.4 MeV and 15.1 MeV) and neutrons in broad energy range (2-10 MeV) were performed in order to evaluate the potential of elemental discrimination.
description: 29 pages, 17 figures
(500660) Benjamin Godwin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
การพยาบาลผู้ป่วยวัณโรคดื้อยารุนแรงหลายขนานชนิดรุนแรงมาก ในสถาบันบำราศนราดูร: กรณีศึกษา
Creators: name: ปิยะวดี สุมาลัย
Publisher: name: กองโรคเอดส์และโรคติดต่อทางเพศสัมพันธ์ กรมควบคุมโรค
Year: 2023
Subjects: วัณโรค
การพยาบาล
เชื้อดื้อยารุนแรงหลายขนาน

description: วารสารโรคเอดส์, 35, 2, 60-68
(502203) _____? [Riddell]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
VITALISE D5.3 Summary of the performed activities for JRA1
Creators: name: Benito, Begoña
name: GARATEA, JOKIN
name: Helsen, Kim
name: Van der Auwera, Vicky
name: Almeida, Rosa
name: Ballesteros, Sofía
name: Nagy, Eniko
name: Azevedo, Nancy
name: Petronikolou, Vasileia
name: Plomariti, Christina
Publisher: name: Zenodo
Year: 2024

description: Although Living Labs have emerged as resilient research and innovation infrastructures and have proved to be a “key” to the integration of research and innovation processes in real-life settings, they still fail to provide and function according to unified and harmonized processes that are easily accessible and exploitable by academic and industrial researchers. VITALISE brings together Living Labs across Europe (and 1 outside Europe in Canada) to create a Thematic ecosystem of Living Labs in the Health and Wellbeing domain, aiming at creating synergies and transnational collaboration opportunities through innovative Joint Research Activities. 

During VITALISE project three Joint Research Activities (JRAs) were implemented among the consortium Living Lab partners. These JRAs included state-of-the-art use cases that investigated AHA and chronic conditions in three important domains for the Health and Wellbeing Research. They were selected based on the consortium’s existing research studies and expertise: Rehabilitation, Transitional care and Everyday living environments (respectively JRA1, JRA2, JRA3).  

The JRA of WP5 focused on the use of supportive technology for rehabilitation interventions and data collection in a rehabilitation context. We primarily aimed to gain insight in each living lab’s infrastructure and procedures in order to harmonise health and wellbeing living lab procedures and infrastructures in Europe and beyond, in particular in the context of rehabilitation. Secondly, we aimed to investigate the potential of innovative technologies for rehabilitation through living lab methodologies. Six small-scale pilot studies were preceded by co-creation sessions. This document presents an overview of the case studies performed in different countries.
Innovations and Collaboration to Influence Policy and Practice: Global Deans Speak
Creators: name: McDiarmid, G. Williamson
Publisher: name: SAGE Publications
Year: 2020

description: For the second consecutive year, education deans and other institutional leaders from around the
globe gathered on the campus of East China Normal University (ECNU) for the Global Education
Deans Forum (GEDF), October 24–25, 2019. Participants came from 10 countries/regions across 5
continents for 2 days of conversations, which included Australia (2), Canada (2), Chinese mainland
(8), Hong Kong SAR (2), Ireland (1), Korea (1), Singapore (1), South Africa (1), Spain (2), the
United Kingdom (3), and the United States (11). Based on suggestions from 2018 GEDF participants,
the focus for conversations was: Increasing the influence of university research on educational
policy and practice. Last year’s participants also requested that deans have time to describe
promising innovations from their institutions.
Vibronic resonances facilitate excited state coherence in light harvesting proteins at room temperature
Creators: name: Novelli, Fabio
name: Nazir, Ahsan
name: Richards, Gethin H.
name: Roozbeh, Ashkan
name: Wilk, Krystyna E.
name: Curmi, Paul M. G.
name: Davis, Jeffrey A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Until recently it was believed that photosynthesis, a fundamental process for life on earth, could be fully understood with semi-classical models. However, puzzling quantum phenomena have been observed in several photosynthetic pigment-protein complexes, prompting questions regarding the nature and role of these effects. Recent attention has focused on discrete vibrational modes that are resonant or quasi-resonant with excitonic energy splittings and strongly coupled to these excitonic states. Here we unambiguously identify excited state coherent superpositions in photosynthetic light-harvesting complexes using a new experimental approach. Decoherence on the timescale of the excited state lifetime allows low energy (56 cm-1) oscillations on the signal intensity to be observed. In conjunction with an appropriate model, these oscillations provide clear and direct experimental evidence that the persistent coherences observed require strong vibronic mixing among excited states.