cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Snapshot in Time: Adolescents' Communicative Preferences through Technology
Creators: name: Lai, Manfred
Publisher: name: The Australian National University
Year: 2019

description: Generation Z (Gen Z) is the new transitional generation in terms of technological exposure and usage. Members of Gen Z may be seated side by side, but it is their mobile digital devices that connect, thumbs tapping incessantly. What are their communicative preferences? How comfortable has this generation been in engaging online? This research seeks to provide benchmarking answers to these questions. This thesis analyses the digital technological engagement of 92 Australian and Singaporean high school and college students (aged 14-17 in 2011). Specifically, it examines communicative preferences, technology consumption habits and technological comfort zones through a survey, interviews and analysis of a series of mediated blogs. Examining the findings through the concept of visuacy and the theories of Goffman (1959) and Erikson (1968), the research suggests that Gen Z experience cognitive and affective dissonance between their acknowledged necessity for digital connectedness and their concurrent need for direct interaction (e.g., face-to-face verbal communication and direct hand/eye technologies such as drawing, painting, and photography). Facebook was the most popular social networking site (SNS) among the research subjects, and their online usage of it aligned with other research at the time. The findings suggest that the students were more likely to be spectators in the mediated online environment than active participants. There were also differences in engaging in mediated versus non-mediated environments (with Australia students preferring the latter and Singaporeans the former). These benchmark findings are compared to subsequent research, reaffirming that the cohort's need for face-to-face communication remains unchanged. This thesis contributes substantially to the body of knowledge as the timing of the data collection occurred during a pivotal period both in terms of technological exposure (availability, usage and the rise of several key SNS sites) and the burgeoning interest of Gen Z in participating online. Developments in this field occur very rapidly, and this research provides an important benchmark. The research outlines an understanding of the impacts of mediated academic/social technology environments on adolescent development and learning in the early 21st century, providing a reference point for future researchers, educators and information technology professionals seeking to design digital platforms and systems.
Non-Trivial Non-Canonical W-Algebras from Kac-Moody Reductions
Creators: name: da Costa, G. A. T. F.
name: O'Raifeartaigh, L.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: By reducing a split $G_2$ Kac-Moody algebra by a non-maximal set of first-class constraints we produce W-algebras which (i) contain fields of negative conformal spin and (ii) are not trivial extensions of canonical W-algebras.
description: 12 pages,Tex,DIAS-STP-94-19
Micro and Small Enterprises (MSEs) in Indonesia: Three Essays
Creators: name: Falentina, Anna
Publisher: name: The Australian National University
Year: 2019

description: This thesis presents three papers on issues related to the sustainable development of micro and small enterprises (MSEs) in Indonesia. The first paper examines the impact of electricity blackouts on the performance of manufacturing MSEs. The identification strategy involves first examining blackouts determinants, and then using these determinants as instruments in an instrumental variable (IV) dynamic panel fixed effects estimation while controlling for factors that potentially affect productivity and are correlated with blackouts. The findings show that the reasons why Indonesia has blackouts are under-investment in the power sector and poor Indonesian national electricity company (Perusahaan Listrik Negara or PLN) governance. The results show that electricity blackouts reduce average labour productivity and that the consequential loss for manufacturing MSEs amounts to approximately IDR 71.5 billion (USD 4.91 million) per year. Introducing a captive generator as a way to cope with power outages is positively associated with productivity and MSEs that have captive generators benefit when the power supply is poor. The second paper examines the effects of internet utilisation, as part of digitalisation, on the performance of MSEs in Yogyakarta. Relying on primary data collected from MSEs in Yogyakarta, the province with the densest MSE population in Indonesia, the identification is achieved through an IV strategy. The paper exploits the fact that the differences in geographic topography produce conceivably exogenous variations in the strength of cellular signal that MSEs in various areas can receive to connect to the internet. Once geographical proximity had been controlled for, the difference in cellular signal strength should be due to geographical happenstance and building development. The findings show that internet utilisation has enabled MSEs to engage in the digital economy and has improved labour productivity and exports. The associated monetary benefit due to internet utilisation is substantial for local people. The final paper evaluates the impact of targeted social assistance programs on MSEs performance as a proxy for the development of local economies. Exploiting variation in the timing of conditional cash transfer implementation in Indonesian subdistricts, the paper examines the effects of a key social assistance program on the performance of local MSEs in Indonesia. The analysis is based on a linear subdistrict fixed effects model, combining data from surveys of manufacturing MSEs with village census data. Results show that exposure to the program contributes to an increase in labour productivity in the medium term. The overall effect is driven by increased productivity in urban areas, in villages close to cities and in non-coastal areas. Women engaged in MSEs are also benefited from the program. No immediate impacts are observed. Relaxing credit constraints appears to be a mechanism through which the program affects MSEs in the local area.
title: Patrice Debré
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: En pièce jointe : présentation de la mission "Les Traitements des Infections aux Virus du SIDA : vers les super (tri) thérapies de troisième génération et la réduction des prises médicamenteuses". 1 fichier (7 pages).
The government gazette. Vol. VIII
Creators: name: British Columbia
Publisher: name: Victoria, B.C. : Government Printing Office
Year: 2017

description: "weekly. Title varies: 3 January 1863--14 November 1871 as Government gazette--British Columbia (published by authority). Published in New Westminster 1863-68; in Victoria, 30 May 1868 to date. Government regulations published separately 1958 to date." -- Lowther, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 22.
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0783
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0783, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0783, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Needle Optimization Study for Equine BMSC Injections
Creators: name: Basha, Rozlan
name: Turner, Kayla
name: Barrett, Jennifer
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: Stem cell treatments are used to treat tissue and cartilage ailments in veterinary regenerative medicine. Three-dimensional spheroid equine bone marrow mesenchymal stem cells (eBMSC) can be used in clinical practice due to their increased anti-inflammatory and regenerative properties as opposed to 2D monolayer stem cells. The standard for veterinarians is to inject stem cells through 22G, 20G and 18G needles with respective diameters of 413μm, 603μm, and 838μm. Spheroid cells are injected with these needles while having an average size of 300-400μm. Smaller needles have the potential to shear stem cells which may lead to early-onset apoptosis and decreased viability. Here we show that 20G and 22G needles show decreased viability for spheroid injection. While not statistically significant, therefore inconclusive at this time, we found that spheroid eBMSC average viability decreased from 85% in the control group to 61% in the 22G treatment group. Interestingly, the 2D monolayer stem cell culture showed an opposite trend of increased viability with smaller needle sizes. A replication of the experiment will be helpful to identify if larger needle sizes reduce the viability of monolayer and spheroid eBMSC, and which needle gauge is optimal for clinical use. We anticipate our needle optimization study to be the basis on which clinicians begin to incorporate needle sizes that ensure the highest stem cell viability and start exploring the use of spheroid cell culture in treating osteoarthritis, and other like ailments in veterinary medicine.
description: Journal of Student-Scientists' Research, Vol. 1 (2019)
Additional file 1: of Frameworks for self-management support for chronic disease: a cross-country comparative document analysis
Creators: name: OâConnell, Selena
name: Carthy, Vera Mc
name: Savage, Eileen
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Electronic Search Strategy. This file depicts the search strategy used for different grey literature databases and search engines. (DOCX 16 kb)
Asymptotic level density in heterotic string theory and rotating black holes
Creators: name: Russo, J. G.
name: Susskind, L.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We calculate the density of states with given mass and spin in string theory and obtain asymptotic formulas. We also compute the tree-level gyromagnetic couplings for arbitrary physical states in the heterotic string theory. These results are then applied to study whether fundamental strings can consistently describe the microphysics of the black hole horizon in the case of a general classical solution characterized by mass, charge and angular momentum.
description: 15 pages, UTTG-9-94
Spiritualism : or modern necromancy. A sermon, with preface and notes
Creators: name: Cridge, Edward, 1817-1913
Publisher: name: Victoria : D. W. Higgins
Year: 2015

description: "Cover title. Not seen." -- Lowther, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 42.
Estimation of lactate threshold with machine learning techniques in recreational runners
Creators: name: Etxegarai, Urtats
name: Portillo, Eva
name: Irazusta, Jon
name: Arriandiaga, Ander
name: Cabanes, Itziar
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Lactate threshold is considered an essential parameter when assessing performance of elite and recreational runners and prescribing training intensities in endurance sports. However, the measurement of blood lactate concentration requires expensive equipment and the extraction of blood samples, which are inconvenient for frequent monitoring. Furthermore, most recreational runners do not have access to routine assessment of their physical fitness by the aforementioned equipment so they are not able to calculate the lactate threshold without resorting to an expensive and specialized centre. Therefore, the main objective of this study is to create an intelligent system capable of estimating the lactate threshold of recreational athletes participating in endurance running sports. The solution here proposed is based on a machine learning system which models the lactate evolution using recurrent neural networks and includes the proposal of standardization of the temporal axis as well as a modification of the stratified sampling method. The results show that the proposed system accurately estimates the lactate threshold of 89.52% of the athletes and its correlation with the experimentally measured lactate threshold is very high (R=0,89). Moreover, its behaviour with the test dataset is as good as with the training set, meaning that the generalization power of the model is high. Therefore, in this study a machine learning based system is proposed as alternative to the traditional invasive lactate threshold measurement tests for recreational runners.
description: 33 pages, 16 figures
Additional file 11: of A two-stage microbial association mapping framework with advanced FDR control
Creators: name: Jiyuan Hu
name: Hyunwook Koh
name: Linchen He
name: Menghan Liu
name: Blaser, Martin
name: Huilin Li
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S4. Candidate groups (at the family rank) associated with STAT exposure, detected by OMiAT or by the aggregated method, respectively, using data from a murine experiment [28] (FDRâ =â 0.05). (PDF 85Â kb)
Cryopreservation of Equine Platelet-rich Plasma
Creators: name: Varthese, Brightney
name: Barrett, Jennifer
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: Platelet-Rich Plasma (PRP) therapy harnesses the healing properties of platelets to treat injuries and wounds. PRP provides growth factors and fibrinogen which clots and forms a scaffold to promote healing. In PRP processing, the patient blood is separated into fractions, and the component with platelets (either with (LPRP) or without (PRP) white blood cells) is used for therapy. This project aims to determine if 10% DMSO cryopreserves blood cells in PRP and LPRP stored at -80C or -140C and to measure associated protein concentrations. Our hypotheses were: PRP blood cells in 10% DMSO at -140C and -80C would be >80% viable, protein levels in PRP without DMSO would be higher than in PRP with DMSO, and protein levels in LPRP without DMSO would be lower than in LPRP with DMSO. Whole blood was processed to generate PRP and LPRP. Samples were stored overnight in 4C, -80C, and -140C with or without 10% DMSO. They were thawed at room temperature, cell viability was measured by a Live/dead assay, and protein concentration was determined using a Bradford assay. 10% DMSO improved cell viability in -80C and -140C, offering a potential method for PRP and LPRP cryopreservation. There was no statistical correlation between percent viability and protein concentration. Data suggest that protein levels are lower after cryopreservation with DMSO than without DMSO. Future directions include quantification of specific proteins within PRP and LPRP and increased storage time to determine cell viability and protein stability under these conditions.
description: Journal of Student-Scientists' Research, Vol 1 (2019)
title: Schéma des densités d'habitation [Rabat-Salé]
title: Schéma des densités d'habitation [Rabat-Salé]
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Habitat

description: Cartographie
description: BESM-carto_1954-60-p158-01_60-02
description: 158
description: 60
description: Bulletin économique et social du Maroc
description: Source: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Source: Bulletin économique et social du Maroc
description: Source: Bulletin économique et social du Maroc (BESM) > BESM (Cartographie)
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/81614
description: Coverage: XXe siècle
description: Coverage: Maroc
description: Coverage: Salé
description: Coverage: Rabat
description: Temporal: XXe siècle
description: Bibliographic citation: « Schéma des densités d'habitation [Rabat-Salé] », In Bulletin économique et social du Maroc (BESM), n° 60, 1954
description: Provenance: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Provenance: https://cinumed.mmsh.univ-aix.fr/
Additional file 1 of DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex
Creators: name: Gasparoni, Gilles
name: Bultmann, Sebastian
name: Lutsik, Pavlo
name: Kraus, Theo F. J.
name: Sordon, Sabrina
name: Vlcek, Julia
name: Dietinger, Vanessa
name: Steinmaurer, Martina
name: Haider, Melanie
name: Mulholland, Christopher B.
name: Arzberger, Thomas
name: Roeber, Sigrun
name: Riemenschneider, Matthias
name: Kretzschmar, Hans A.
name: Giese, Armin
name: Leonhardt, Heinrich
name: Walter, Jörn
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary Figures.
Rehabilitation Technology and Relapse-Detecting Software for Recovering Opioid Addiction Patients
Creators: name: Valencia, Diego
name: Kendall Johnson, Kendall Johnson
name: Matto, Holly
name: Seshaiyer, Padmanabhan
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: Opioid addiction rates in the United States have been on the rise for decades, but the expansion of rehabilitation programs cannot keep up. In 2013, an estimated 20.4 million people out of 22.7 million who required treatment for illicit drug addiction failed to receive proper treatment at specialty facilities. Without proper rehabilitation, patients can fall back into a cycle of substance abuse. Considering the societal stigma of addiction and seeking treatment therefor, technological rehabilitation provides a more conservative alternative for these patients in terms of cost, privacy, and convenience. The goal of this mathematical modeling project is to develop a discreet wearable device that will determine whether a patient is having a response to a stressor, which indicates the potential for a relapse event. In this project, we created a prototype with a heart rate sensor and Raspberry Pi Zero with the Python module scikit-learn to measure heart rate and implement machine learning algorithms. These algorithms were used to perform data analysis that would evaluate Heart Rate Variability (HRV) and make complex predictions. This project has helped us to provide insight into how technology can be used for opioid addiction treatment. In addition, it has helped to substantiate how heart rate values can be used to evaluate HRV, a more accurate determinant of emotional responses to stimuli. We hope to further develop and deploy our prototype with the user community to validate the mathematical model and computational algorithms.
description: Journal of Student-Scientists' Research, Vol 1 (2019)
Thermal ensemble of string gas in a magnetic field
Creators: name: Russo, J. G.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the thermal ensemble of a gas of free strings in presence of a magnetic field. We find that the thermodynamical partition function diverges when the magnetic field exceeds some critical value $B_{\rm cr}$, which depends on the temperature. We argue that there is a first-order phase transition with a large latent heat. At the critical value an infinite number of states -all states in a Regge trajectory- seem to become massless, which may be an indication of recuperation of spontaneously broken symmetries.
description: 9 pages, 1 figure (fig1.eps, included at the bottom), UTTG-10-94
Conditions of Access: Mapping the value of Australian novels in the twenty-first century global marketspace
Creators: name: Lawson, Airlie
Publisher: name: The Australian National University
Year: 2019

description: What is the value of Australian novels in the twenty-first century global marketspace? Competing accounts about the extent of the international circulation of contemporary Australian literature and the conditions under which works circulate have informed policy advice to the Australian Government about changes to territorial copyright laws, fuelled a public narrative in which Australian access to the world literary sphere is a case of exceptions, and structured industry practices related to circulation. Academic understanding has been determined by data availability and a focus on the evidence of circulation rather than the material processes of the export trade, the less visible aspect of which is the export of intellectual property, often referred to as 'selling rights'. With no comprehensive record of 'rights' activity available, these multiple accounts have led to many empirically untested theories about why the rights to Australian literature do 'sell'. Focusing on the novel -- and conceiving of the international rights as not 'sold' but licensed in a conditional cultural exchange -- provides the study with an indicator for 'literature' and 'the global'. This thesis conceptualises these rights as traded within a global marketspace from which works of sufficient value are offered entry onto an international licensing field. Integrating this rights-specific frame within a three-tiered sociology of translation exchange model, the value of a work can be shown to be determined by international power relations, national consecration, and local networks: not, as is often claimed, by the quality or the subject matter of a work. To build the two-part database this study uses to map circulation, measure value and demonstrate this process, it draws on the license itself to create a 'transaction' and an 'influence' data set. The license provides evidence of transactions, digitally linking the constellation of information surrounding the license as a way to measure 'influence'. By mapping circulation in this manner, this study creates a new data-driven account in which Australian literature has a different value in the domestic marketplace and global marketspace. Not only is there more international access during the first fifteen years of the twenty-first century, in this space women authors receive a high amount of critical attention, genre fiction is highly visible, and literary fiction is not in decline. Overall, the international value of Australian literature can be seen to have increased over the period.
Clear variation of spin splitting by changing electron distribution at non-magnetic metal/Bi2O3 interfaces
Creators: name: Tsai, Hanshen
name: Karube, Shutaro
name: Kondou, Kouta
name: Yamaguchi, Naoya
name: Ishii, Fumiyuki
name: Otani, Yoshichika
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Large spin splitting at Rashba interface, giving rise to strong spin-momentum locking, is essential for efficient spin-to-charge conversion. Recently, a Cu/Bismuth oxide (Bi2O3) interface has been found to exhibit an efficient spin-to-charge conversion similar to a Ag/Bi interface with large Rashba spin splitting. However, the guiding principle of designing the metal/oxide interface for the efficient conversion has not been clarified yet. Here we report strong non-magnetic (NM) material dependence of spin splitting at NM/Bi2O3 interfaces. We employed spin pumping technique to inject spin current into the interface and evaluated the magnitude of interfacial spin-to-charge conversion. We observed large modulation and sign change in conversion coefficient which corresponds to the variation of spin splitting. Our experimental results together with first-principles calculations indicate that such large variation is caused by material dependent electron distribution near the interface. The results suggest that control of interfacial electron distribution by tuning the difference in work function across the interface may be an effective way to tune the magnitude and sign of spin-to-charge conversion and Rashba parameter at interface.
Crowd Microservices Hackathon: Utilizing Crowdsourcing for Microtask Programming on a Large-Scale
Creators: name: Dubey, Aarushi
name: LaToza, Thomas
name: Emad Aghayi, Emad Aghayi
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: Developers in the working community often face the difficulty of training quickly into a new project, especially with new software. Building software through microtask programming offers new opportunities for enabling software developers to more easily join software projects as well as reduce the time to market. In microtask programming, all software development work occurs through microtasks, short self-contained 10 minute tasks. Microtask programming offers new opportunities for software projects by reducing the amount of project knowledge developers must learn to contribute and enabling more work to be done in parallel. To better explore the scalability of microtask programming to realistic software projects, we are currently planning a large-scale virtual ‘hackathon’. Participants will work to build a microservice for “Where”, a map web app for the Mason campus which helps students with finding the way to their classes, finding study spots, and which buses to catch. In the hackathon, participants will use microtask programming to work together on a single software project, offering new insight into the scalability of software projects to more simultaneous contributors.
description: Journal of Student-Scientists' Research, Vol 1 (2019)
A General Account of Argumentation with Preferences
Creators: name: Modgil, Sanjay
name: Prakken, Henry
Publisher: name: arXiv
Year: 2018
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: This paper builds on the recent ASPIC+ formalism, to develop a general framework for argumentation with preferences. We motivate a revised definition of conflict free sets of arguments, adapt ASPIC+ to accommodate a broader range of instantiating logics, and show that under some assumptions, the resulting framework satisfies key properties and rationality postulates. We then show that the generalised framework accommodates Tarskian logic instantiations extended with preferences, and then study instantiations of the framework by classical logic approaches to argumentation. We conclude by arguing that ASPIC+'s modelling of defeasible inference rules further testifies to the generality of the framework, and then examine and counter recent critiques of Dung's framework and its extensions to accommodate preferences.
description: This paper contains correction to errors in the original paper which appears in the journal Artificial Intelligence
Additional file 1 of Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects
Creators: name: Xie, Xue
name: Gao, Wei
name: Hao, Junnian
name: Wu, Jianrong
name: Cai, Xiaojun
name: Zheng, Yuanyi
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Fig. S1.TEM images of PBs with different magnification. Fig. S2. FTIR spectra of PBs. Fig. S3. Photothermal-heating curves of PBs at elevated concentrations under 808 nm laser irradiation. Fig. S4. Photothermal-heating curves of PBs dispersed in aqueous solution irradiated at different power intensity (0.2, 0.4, 0.8 and 1.0 W cm−2). Fig. S5. In vitro photothermal performance of PBs. Fig. S6. Digital photographs and the UV–vis-NIR absorbance of PBs dispersed in pure water and saline. Fig. S7. UV–vis-NIR absorbance spectra of PBs dispersions before and after irradiation for 10 min and 30 min by 808 nm Laser, respectively. Fig. S8. Viability of 4T1 cells incubated with different concentrations of PBs (0, 25, 50, 100, 200, and 400 µg mL−1) for 12, 24, and 48 h. Fig. S9. a Viability of 4T1 cells after different treatments. b Viability of 4T1 cells after photothermal therapy with different PBs concentrations upon laser irradiation. c Viability of 4T1 cells treated with PBs (100 μg mL−1) upon laser irradiation at varied power densities for 10 min. Fig. S10. CLSM images of 4T1 cells stained by calcein-AM and propidium iodide after different treatments. Fig. S11. a UV–vis-NIR and b fluorescence spectra of PBs and FITC-labeled PBs. Fig. S12. CLSM images of 4T1 cells incubated with FITC-labeled PBs (100 μg mL−1) for 0, 1, 2 and 4 h. Fig. S13. Viability of RAW 264.7 macrophages incubated with different treatments. Fig. S14. Levels of inflammatory cytokines in RAW 264.7 macrophages incubated with different treatments. Fig. S15. Flow cytometry analysis of CD3+, CD3+CD8+, and CD3+CD4+ T cells in the blood. Fig. S16. Flow cytometry analysis of CD3+, CD3+CD8+, and CD3+CD4+ T cells in the liver. Fig. S17. Flow cytometry analysis of CD3+, CD3+CD8+, and CD3+CD4+ T cells in the spleen. Fig. S18. The hematoxylin and eosin staining of liver in various groups. Fig. S19. Temperature curves at the tumor region of 4T1-tumor-bearing nude mice in different groups under 808 nm laser irradiation for 10 min. Fig. S20. Time-dependent body-weight curves of 4T1 tumor-bearing nude mice. Fig. S21. H&E-staining tissue of major organs.
Strategies to Overcome Multi-Drug Resistance in Cancer
Creators: name: Muthiah, Divya
Publisher: name: The Australian National University
Year: 2018
Subjects: Cancer
Multi-Drug Resistance
ABC Transporters
ABCB1
ABCG2
Chemotherapy
Noscapine
ZSTK474

description: Multidrug resistance (MDR) is a common cause of chemotherapy treatment failure and can be a significant obstacle in cancer therapy. A key contributor to MDR is the overexpression of ABC transporters such as ABCB1 and ABCG2. Over the last 30 years researchers have identified three generations of inhibitors to overcome drug resistance caused by ABCB1 and ABCG2. Despite intensive efforts, a clinically usable inhibitor is yet to be identified. All three generations of inhibitors have failed due to poor cytotoxic potency, off target effects or adverse reactions. An alternative strategy to overcome MDR could be to use compounds that not only inhibit the transporter but also indirectly overcome resistance by down regulating expression of the relevant transporter through signal transduction pathways. This investigation aimed to overcome ABCB1- and ABCG2- mediated drug resistance and inhibit cancer cell proliferation using novel noscapine derivatives or the kinase inhibitor ZSTK474, in combination with existing anticancer agents such as vinblastine or mitoxantrone. It also aimed to elucidate the mechanism of action of these compounds and determine if these compounds directly or indirectly inhibited the function of ABCB1 and ABCG2. Noscapine and its derivatives were anti-proliferative in control wildtype cells (MCF7WT), and cancer cells overexpressing ABCB1 (NCI/ADRRES) or ABCG2 (MFC7FLV1000). The activity of compounds were also unaffected by the expression of ABCB1 and ABCG2. The combination of noscapine or selected noscapine derivatives with currently used anti-cancer agents potentiated anti-proliferative 11 effects in all three cell lines. Noscapine and it derivatives achieved potentiation by a) using inherent anti-cancer activity that is unaltered in the presence of ABCB1 and ABCG2 and b) increasing intracellular drug accumulation by directly inhibiting the efflux by the pump. ZSTK474 was anti-proliferative and its activity was unaffected by the ABCB1 and ABCG2 expression. The combination of ZSTK474 with anti-cancer agents in sensitive and resistant cells produced synergistic anti-proliferative effects. ZSTK474 achieved synergy by a) being unaffected by the resistance phenotype and inhibiting cancer cell proliferation, b) reducing ABCB1 and ABCG2 expression by inhibition of protein synthesis, and c) by increasing intracellular substrate accumulation via inhibition of efflux mediated by ABCB1 and ABCG2. In summary, ZSTK474 and selected noscapine derivatives overcame the resistance phenotype via multiple modes of action. The use of ZSTK474 or noscapine derivatives with anti-cancer agents used in the clinic could overcome ABCB1- or ABCG2-mediated MDR to reduce side effects for cancer patients and warrants further investigation.
W_{1+\infty} and W(gl_N) with central charge N
Creators: name: Frenkel, E.
name: Kac, V.
name: Radul, A.
name: Wang, W.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study representations of the central extension of the Lie algebra of differential operators on the circle, the W-infinity algebra. We obtain complete and specialized character formulas for a large class of representations, which we call primitive; these include all quasi-finite irreducible unitary representations. We show that any primitive representation with central charge N has a canonical structure of an irreducible representation of the W-algebra W(gl_N) with the same central charge and that all irreducible representations of W(gl_N) with central charge N arise in this way. We also establish a duality between "integral" modules of W(gl_N) and finite-dimensional irreducible modules of gl_N, and conjecture their fusion rules.
description: 29 pages, Latex, uses file amssym.def (a few remarks added, typos corrected)
Department of State. Correspondence concerning questions pending between Great Britain and the United States
Creators: name: United States. Department Of State
Publisher: name: Washington : Government Printing Office
Year: 2016

description: "At head of title: Department of State. Relates in part to the San Juan Island dispute." -- Lowther, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 43.

"Transmitted to the Senate in obedience to a resolution." -- Title page.
Machine Learning Based Facial Recognition
Creators: name: Singh, Taaren
name: Ikonomidou, Vasiliki
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: Humans have an innate ability to recognize faces in nearly any situation, allowing us to differentiate one person from another, regardless of the environment. Local binary patterns (LBP) utilize depth perception to quantify the pixels of a subject’s face depending on the person’s unique facial structure. Through machine learning methodology, multiple faces can be stored in a system over time (known as training the system). As a system encounters more faces, its database expands and correspondingly grows artificially “smarter”, being able to identify more individuals. Using Python, a facial classifier was coded utilizing LBP to collect and store subjects’ faces with their corresponding names. Afterward, a live feed recognizer was coded, which also utilized LBP to convert live frames into grayscale images that could be compared and paired with those stored from the facial classifier. It was expected that the classifier would be about 80% accurate due to the camera quality used during the development phase. Ultimately, exploring recognition systems driven by machine learning can help further research in facial feature detection for analytical purposes.
description: Journal of Student-Scientists' Research, Vol 1 (2019)
Assisted immigration
Creators: name: Pearse, B. W. (Benjamin William), 1832-1902
Publisher: name: Victoria : Office of the Immigration Board
Year: 2015

description: "States terms of assistance for those wishing to emigrate to British Columbia." -- Lowther, B. J., & Laing, M. (1968). A bibliography of British Columbia: Laying the foundations, 1849-1899. Victoria, BC: University of Victoria, p. 41.
Additional file 4 of Multi-omics profiling reveals microRNA-mediated insulin signaling networks
Creators: name: Lin, Yang-Chi-Dung
name: Huang, Hsi-Yuan
name: Shrestha, Sirjana
name: Chou, Chih-Hung
name: Chen, Yen-Hua
name: Chen, Chi-Ru
name: Hong, Hsiao-Chin
name: Li, Jing
name: Chang, Yi-An
name: Chiew, Men-Yee
name: Huang, Ya-Rong
name: Tu, Siang-Jyun
name: Sun, Ting-Hsuan
name: Weng, Shun-Long
name: Tseng, Ching-Ping
name: Huang, Hsien-Da
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4. Supplementary Information.
Zenith angle distribution of cosmic ray showers measured with the Yakutsk array and its application to analysis of arrival directions in equatorial coordinates
Creators: name: Ivanov, A. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Yakutsk array dataset in the energy interval $(10^{17},10^{19})$ eV is revisited in order to interpret the zenith angle distribution of an extensive air shower event rate of ultra-high energy cosmic rays. The close relation of the distribution to the attenuation of the main measurable parameter of showers, $S_{600}$, is examined. Measured and expected distributions are used to analyze the arrival directions of cosmic rays on an equatorial map including the energy range below $10^{18}$ eV, which was previously avoided due to the reduced trigger efficiency of the array in the range. While the null hypothesis cannot be rejected with data from the Yakutsk array, an upper limit on the fraction of cosmic rays from a separable source in the uniform background is derived as a function of declination and energy.
description: 9 pages, 9 figures, 3 tables, submitted to PRD
Reliability of Color-Based Pulse Detection Heart Rate Variability Analysis Software
Creators: name: Song, Karen
name: Ikonomidou, Vasiliki
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: When a human heart pumps blood, there are slight color changes in the forehead. These changes are unobservable by the naked eye but are detectable through cameras. Color-based pulse detection records the color change of a video subject’s forehead and outputs the RR intervals (time intervals between subsequent heartbeats); however, video quality can interfere with this process. One aspect that affects video quality is file compression. To test the reliability of color-based pulse detection and its dependence on the file format chosen, I examined 5 file compressions (.avi, .mov, .mpg, .wmv, and .mp4) on 5 videos of a light-complexioned subject and a dark-complexioned subject and compared the mean heart rate computed using color-based pulse detection with RR intervals generated from the Pan-Tompkins algorithm of electrocardiogram (ECG) signals on the subjects. For the light-complexioned subject, the .mpg compression yielded the highest correlation with the ECG data (r squared = 0.953). For the dark-complexioned subject, it was found that .avi yielded the highest correlation (r squared = 0.812), a significantly lower coefficient than that of the light-complexioned subject. This indicates that while compression seems to have a minimal effect when starting with a high signal-to-noise ratio (light-skinned subject), it does deteriorate algorithm performance at a lower signal-to-noise ratio (dark-skinned subject). It is important to know the consistency of this method at different levels of video quality and compression. However, this research points to the fact that compression may challenge video-based heart rate detection in darker complexioned people.
description: Journal of Student-Scientists' Research, Vol 1 (2019)
MOESM1 of DNA methylation analysis on purified neurons and glia dissects age and Alzheimerâ s disease-specific changes in the human cortex
Creators: name: Gasparoni, Gilles
name: Bultmann, Sebastian
name: Lutsik, Pavlo
name: Kraus, Theo
name: Sordon, Sabrina
name: Vlcek, Julia
name: Dietinger, Vanessa
name: Steinmaurer, Martina
name: Haider, Melanie
name: Mulholland, Christopher
name: Arzberger, Thomas
name: Roeber, Sigrun
name: Riemenschneider, Matthias
name: Kretzschmar, Hans
name: Giese, Armin
name: Leonhardt, Heinrich
name: JĂśrn Walter
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Additional file 1. Supplementary Figures.
The minimally anisotropic metric operator in quasi-Hermitian quantum mechanics
Creators: name: Krejcirik, David
name: Lotoreichik, Vladimir
name: Znojil, Miloslav
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: Spectral Theory (math.SP)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We propose a unique way how to choose a new inner product in a Hilbert space with respect to which an originally non-self-adjoint operator similar to a self-adjoint operator becomes self-adjoint. Our construction is based on minimising a 'Hilbert-Schmidt distance' to the original inner product among the entire class of admissible inner products. We prove that either the minimiser exists and is unique, or it does not exist at all. In the former case we derive a system of Euler-Lagrange equations by which the optimal inner product is determined. A sufficient condition for the existence of the unique minimally anisotropic metric is obtained. The abstract results are supplied by examples in which the optimal inner product does not coincide with the most popular choice fixed through a charge-like symmetry.
description: 14 pages
Reconstructions of Digitally Uploaded Neurons
Creators: name: Dasari, Akhila
name: Wingate, Helen
name: Plaxe, Daniel
name: Ascoli, Giorgio
Publisher: name: Journal of Student-Scientists' Research
Year: 2019

description: NeuroMorpho.Org is an online, centrally curated repository of reconstructed neuronal morphologies containing contributions from over 500 labs of more than 50 animal species. Version 7.8 contains 112,244 downloadable digital reconstructions. Pooling data together provide increased research opportunities. The curation process involves three stages. First, potential journal articles are sourced by a search program that feeds into a database for expert review. Articles are manually labeled as positive or negative based on the presence of neuronal reconstructions and positive data are requested from the authors. Next, new neurons received are prepared for upload through visual inspection: custom-built and commercial research software are used to manually edit the morphologies before post-processing with automated programs that scan the files for residual errors. Once approved, the neurons are grouped by and carefully annotated for experimental condition and other essential biological details, including brain region and microscopic imaging modality. As an ever-growing repository, NeuroMorpho.Org tallies 13,720,290 downloads (corresponding to more than 2.5 million hours of manual reconstructions) from over 160 countries.
description: Journal of Student-Scientists' Research, Vol. 1 (2019)
Corporate political activity agents: Understanding how firms use expert consultants to transmit information to regulators of risky products
Creators: name: Buffinton, Lisa
Publisher: name: The Australian National University
Year: 2019

description: This thesis contributes to understanding how firms use expert consultants to transmit information with regulators of risky products. This topic has been extensively investigated regarding the tobacco industry but is not as well-understood in relation to the alcohol industry. Alcohol shares similarities with tobacco as a legal, widely-consumed yet disease-bearing product that is regulated to influence the incidence of harms. Submissions to Australian government regulators reveal that liquor retailers have used expert consultants to resist harm prevention policies that restrict alcohol availability and promotion. Three analyses were performed to explore this topic. First, an extensive literature review examines current knowledge on the corporate political activities (CPA) of industries who are specially regulated to mitigate health risks. Second, a taxonomy was developed to define how the tobacco industry used expert consultants for CPA purposes. Third, this taxonomy was applied to three cases where an Australian alcohol retailer used CPA expert consultants. This thesis found that firms use expert consultants as CPA agents when there is an "information threat" that may pose an existential threat to the firm. CPA expert consultants were used to transmit information in a manner that achieves special perlocutionary speech effects in the policy arena. This thesis found 23 characteristics of how expert consultants are used by firms as CPA agents; of which, 15 were newly-identified, distinct characteristics of this practice. The 23 characteristics can be grouped among four thematic dimensions: distinct motivating factors (motivators), strategic and tactical CPA approaches to using expert consultants, and the distinct attributes of CPA expert consultants. Each characteristic is supported by between six and 22 of the 24 source articles. This thesis also found significant parallels between the tobacco and alcohol industries in their use of CPA expert consultants. This thesis concludes that Industrial expert consultants are not disinterested authorities on the subjects for which their services are commissioned. Rather, they are agents of their industrial sponsor's political interests. Consequently, any information they produce and submit to regulators should be understood in the context of pursuing the industries interests and made publicly-available to support transparent policy-making.