title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð³Ð»ÑÐºÐ¾ÐºÐ¾ÑÑÐ¸ÐºÐ¾Ð¸Ð´Ð¾Ð² Ð½Ð° Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ Ð½ÐµÐ¹ÑÐ¾ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Influence of glucocorticoids on neurospecific proteins production
Creators: name: Ð¢ÑÑÑÐ½Ð½Ð¸Ðº, Ð¢Ð°ÑÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð³Ð»ÑÐºÐ¾ÐºÐ¾ÑÑÐ¸ÐºÐ¾Ð¸Ð´Ñ
GAP-43
ÑÐ¸ÑÐ¾Ð·Ð¸Ð½Ð³Ð¸Ð´ÑÐ¾ÐºÑÐ¸Ð»Ð°Ð·Ð°
Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½
glucocorticoids
tyrosine hydroxylase
dexamethasone

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð´Ð¾Ð·Ð¾Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾Ð³Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½Ð° Ð½Ð° ÑÑÐ¾Ð²ÐµÐ½Ñ Ð¼Ð ÐÐ, Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ GAP-43 Ð¸ ÑÐ¸ÑÐ¾Ð·Ð¸Ð½Ð³Ð¸Ð´ÑÐ¾ÐºÑÐ¸Ð»Ð°Ð·Ñ. ÐÐ¾Ð²ÑÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð¸ GAP-43 Ð¸ Ð¢Ð Ð² Ð¦ÐÐ¡ Ð¼Ð¾Ð³Ð»Ð¾ Ð±Ñ ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²Ð¾Ð²Ð°ÑÑ Ð¸Ð½ÑÐµÐ½ÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¿Ð»Ð°ÑÑÐ¸ÑÐµÑÐºÐ¸Ñ/ÑÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð² Ð¼Ð¾Ð·Ð³Ðµ, ÑÑÐ¾ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ Ð´Ð»Ñ Ð»ÐµÑÐµÐ½Ð¸Ñ ÑÑÐ´Ð° Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹. Ð ÑÐ²ÑÐ·Ð¸ Ñ ÑÑÐ¸Ð¼, ÑÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð° Ð¾ÑÐµÐ½ÐºÐ° Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð³Ð»ÑÐºÐ¾ÐºÐ¾ÑÑÐ¸ÐºÐ¾Ð¸Ð´Ð¾Ð² (Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½Ð°) Ð½Ð° Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ Ð½ÐµÐ¹ÑÐ¾ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð² (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÑÐ¸ÑÐ¾Ð·Ð¸Ð½Ð³Ð¸Ð´ÑÐ¾ÐºÑÐ¸Ð»Ð°Ð·Ñ Ð¸ Ð±ÐµÐ»ÐºÐ° GAP-43). ÐÐºÐ°Ð·Ð°Ð»Ð¾ÑÑ, ÑÑÐ¾ Ð² Ð¿ÑÐ¾Ð¼Ð¾ÑÐ¾ÑÐµ Ð³ÐµÐ½Ð° GAP-43 ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¸ ÐºÑÑÑÑ Ð¾ÑÑÑÑÑÑÐ²ÑÑÑ Ð¿Ð¾ÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸, ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ðµ Ð¸Ð·Ð²ÐµÑÑÐ½ÑÐ¼ ÑÐ°Ð¹ÑÐ°Ð¼ ÑÐ²ÑÐ·ÑÐ²Ð°Ð½Ð¸Ñ Ñ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð¼ Ð³Ð»ÑÐºÐ¾ÐºÐ¾ÑÑÐ¸ÐºÐ¾Ð¸Ð´Ð¾Ð². ÐÐ½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð¾Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½Ð° ÐºÑÑÑÐ°Ð¼ Ð²ÑÐ·ÑÐ²Ð°ÐµÑ Ð´Ð¾Ð·Ð¾Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾Ðµ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð¸ Ð¼Ð ÐÐ Ð¸ Ð±ÐµÐ»ÐºÐ° GAP-43 Ð² ÐºÐ»ÐµÑÐºÐ°Ñ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð°. ÐÐ½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð¾Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½Ð° ÐºÑÑÑÐ°Ð¼ Ð² Ð´Ð¾Ð·Ðµ 4 Ð¼Ð³/ÐºÐ³ Ð²ÑÐ·ÑÐ²Ð°ÐµÑ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð¸ Ð¼Ð ÐÐ Ð¸ Ð±ÐµÐ»ÐºÐ° ÑÐ¸ÑÐ¾Ð·Ð¸Ð½Ð³Ð¸Ð´ÑÐ¾ÐºÑÐ¸Ð»Ð°Ð·Ñ Ð² ÐºÐ»ÐµÑÐºÐ°Ñ ÑÑÑÐ¸Ð°ÑÑÐ¼Ð°; Ð¿ÑÐ¸ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ð¸ Ð´Ð¾Ð·Ñ Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½Ð° Ð´Ð°Ð½Ð½ÑÐ¹ ÑÑÑÐµÐºÑ Ð¾ÑÐ¼ÐµÐ½ÑÐµÑÑÑ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð´ÐµÐºÑÐ°Ð¼ÐµÑÐ°Ð·Ð¾Ð½ Ð¼Ð¾Ð¶ÐµÑ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°, ÑÑÐ¸Ð»Ð¸Ð²Ð°ÑÑÐµÐ³Ð¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ Ð½ÐµÐºÐ¾ÑÐ¾ÑÑÑ Ð½ÐµÐ¹ÑÐ¾ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð².
description: This paper is devoted to the study of dose-dependent dexamethasone influence on mRNA level and production of GAP-43 and tyrosine hydroxylase. The increase of GAP-43 and tyrosine hydroxylase production in CNS could contribute to the plastic/regenerative processes intensification in the brain, which is necessary for the treatment of a number of neurodegenerative diseases. Therefore, the aim of this work was to evaluate the effect of glucocorticoids (dexamethasone) on the production of neurospecific proteins (on the example of tyrosine hydroxylase and GAP-43 protein). The GAP-43 gene promoter in humans and rats appeared to lack sequences corresponding to known glucocorticoid receptor binding sites. Intraperitoneal administration of dexamethasone to rats causes dose-dependent mRNA and protein production increase of GAP-43 in hippocampal cells. Intraperitoneal administration of dexamethasone to rats at a dose of 4 mg/kg causes an increase in mRNA and protein production of tyrosine hydroxylase in the striatum cells; with increasing dose of dexamethasone this effect is canceled. Thus, dexamethasone can be considered as a drug that enhances the production of certain neurospecific proteins.