cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Methionine Oxidation Changes the Mechanism of Aβ Peptide Binding to the DMPC Bilayer
Creators: name: Lockhart, Christopher
name: Smith, Amy K.
name: Klimov, Dmitri K.
Publisher: name: Scientific Reports
Year: 2019

description: Using all-atom explicit solvent replica exchange molecular dynamics simulations with solute tempering, we study the efect of methionine oxidation on Aβ10–40 peptide binding to the zwitterionic DMPC bilayer. By comparing oxidized and reduced peptides, we identifed changes in the binding mechanism caused by this modifcation. First, Met35 oxidation unravels C-terminal helix in the bound peptides. Second, oxidation destabilizes intrapeptide interactions and expands bound peptides. We explain these outcomes by the loss of amphiphilic character of the C-terminal helix due to oxidation. Third, oxidation “polarizes” Aβ binding to the DMPC bilayer by strengthening the interactions of the C-terminus with lipids while largely releasing the rest of the peptide from bilayer. Fourth, in contrast to the wild-type peptide, oxidized Aβ induces signifcantly smaller bilayer thinning and drop in lipid density within the binding footprint. These observations are the consequence of mixing oxidized peptide amino acids with lipids promoted by enhanced Aβ conformational fuctuations. Fifth, methionine oxidation reduces the afnity of Aβ binding to the DMPC bilayer by disrupting favorable intrapeptide interactions upon binding, which ofset the gains from better hydration. Reduced binding afnity of the oxidized Aβ may represent the molecular basis for its reduced cytotoxicity.
Artificial neural networks for thermochemistry incorporating conservation laws
Creators: name: Readshaw, Thomas
Publisher: name: Imperial College London
Year: 2022

description: The real time integration of the chemical kinetics in reacting flows consumes the majority of the computational time required when using many simulation techniques. Tabulation of the chemical kinetics using artificial neural networks (ANNs) has the potential to alleviate this computational bottleneck. ANN approaches should have high prediction accuracy but remain as general as possible in order to increase the range of applications and so the potential speed-up. Additionally, it is desirable for ANNs to be physically consistent with the chemical kinetics they replace. In this thesis the generality of ANN approaches is advanced using a random data generation method, which takes data from canonical combustion problems and modifies it to expand the composition space covered. ANN accuracy is improved by using a quasi-second order training algorithm, an automatic approach to regularisation and by predicting the reaction behaviour of each species individually. The accuracy of the ANN tabulation method is demonstrated via its application to large eddy simulations using transported probability density function closure for the filtered reaction source terms, with numerical solution using stochastic fields. Statistics obtained from two such simulations of a non-premixed \ce{CH4}/air jet flame with a thirty one species mechanism using conventional real time integration and the ANN tabulation method respectively, show excellent agreement for major species and good agreement for minor species, while the time required for reaction source term calculations is reduced eighteen fold. The range of applications of ANN thermochemistry tabulation is then expanded by simulating turbulent swirl-stabilised bluff-body \ce{CH4}/air premixed jet flames with the same thirty one species mechanism. Recirculation zones near the bluff-body in these flames require very high prediction accuracy to prevent the accumulation of prediction errors affecting downstream predictions, particularly for minor species. The required prediction accuracy is therefore obtained by automatically dividing the output ranges for each species by their magnitudes and using separate ANNs for each. Excellent agreement is observed between statistics collected from simulations using the ANN method and those obtained when using conventional integration, with a reaction source term calculation speed-up of fourteen times. A method for ensuring physical consistency by enforcing the conservation laws when using ANN thermochemistry tabulation is then developed and applied to simulations of methane/air and propane/air flames. The results of these simulations show that enforcing the conservation laws positively impacts the accuracy of ANN predictions while incurring an insignificant extra computational cost. This conservation method can be readily appended to existing ANN architectures and also be applied to data generation and the prediction of reaction rates.
Development of a platform for automated, two-photon targeted quad patch-clamping of neurons
Creators: name: Vera Gonzalez, Gema
Publisher: name: Imperial College London
Year: 2023

description: Whole-cell patch-clamp allows for the study of ion channel biophysics, membrane properties, and synaptic responses in intact brains. Multi-patching promises to elucidate the functional and connectivity properties of neuronal microcircuits, but the high skill and labour required (and low throughput) hinders its widespread dissemination. Automated multi-patching may solve this problem, but current ‘blind’ autopatchers are impractical for targeting non-primary cell types or perform connectivity studies. We have developed an automated two-photon targeted quad-channel patch-clamping technology platform for ex vivo electrophysiology, extending the system of Annecchino et al. (Neuron 2017, 95:1048-55), as a promising step towards an in vivo targeted, quad-patching setup. The platform comprises a two-photon microscope, four micromanipulators (Sensapex/Scientifica) fitted with mechanical stability clamps (to improve pipette resistance against vibration, tissue deformation and pressure changes), custom-developed electronically-controlled pressure regulator, patch-clamp amplifier and DAQs. Control is via a custom-developed LabView program which acquires frames directly from the microscope. After each trial, pipettes are automatically cleaned and returned to their previous positions, allowing for their reuse. A ‘follow’ function is available to allow the user to move a single pipette and have the rest follow, both in the z and x/y coordinates, to facilitate patching in new, undisturbed brain regions. Temperature control for the perfusion system is also possible within the software. The output and cell information of each channel is automatically recorded for each trial. Basic injection and connectivity protocols are also available to run within the program, making the software a complete set for the basic needs of any experimenter, regardless of their skill set. Our targeted quad patch-clamp system allows scalable and reproducible electrophysiology studies to be conducted across a variety of laboratory settings, offering for the first time robotically automated recording of subthreshold signals from multiple genetically and optically targeted cells simultaneously.
Zhong fu tang xu xuan lin zheng zhi nan : si juan [volume 02]
種福堂續選臨證指南 : 四卷 [第二冊]
Creators: name: (:Null)
Publisher: name: [China] : [Ju yi tang]
Year: 2017

description: On double leaves, East Asian binding.
Edition: [Ke ben]
title: Contributions to ROC Curve and Likelihood Ratio Estimation for Forensic Evidence Interpretation
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2020

description: Biometric traits such as faces and fingerprints are critical in forensic evidence interpretation. There has been a growing interest to study the repeatability, reproducibility, and accuracy of modalities for forensic evidence interpretation since the 2009 National Research Council report and the more recent report from the 2016 President's Council of Advisors on Science and Technology. In this dissertation, we investigate two statistical methods for forensic evidence interpretation, which are score-based likelihood ratio (SLR) and receiver operating characteristic (ROC) curve. In the first part of this dissertation, we investigate the repeatability and reproducibility of three existing statistical methods for estimating the SLR including parametric estimation, kernel density estimation, and recently adopted logistic regression estimation. We perform extensive simulations and used different face and fingerprint biometric datasets to investigate the repeatability and reproducibility of the existing SLR estimation methods. We also provide a parametric way to estimate the variance of the SLR based on the ROC curves. Simulation studies and real studies are provided to indicate the usefulness of the variance estimation method. In the second part, we consider modeling of ROC curves using both the order constraint and covariates associated with each score given that the latter (e.g., demographic characteristics of the underlying subjects) often have a substantial impact on discriminative accuracy. The proposed method is based on the indirect ROC regression approach using a location-scale model, and quadratic optimization is used to implement the order constraint. The statistical properties of the proposed order-constrained least squares estimator are studied. Several situations are discussed in the simulation studies, including multiple covariates, non-Gaussian random samples, and heteroscedastic modeling. The results of the simulation studies corroborate the superior performance of the proposed approach. Its practical usefulness is demonstrated applying face recognition data from the “Good, Bad, and Ugly” face challenge, a domain in which accounting for covariates has hardly been studied.
Supplementary document for Passively CEP stable sub-2-cycle source in the mid-infrared by adiabatic difference frequency generation - 6307108.pdf
Creators: name: Ritzkowsky, Felix
name: Bebeti, Felix
name: Rossi, Giulio Maria
name: Mainz, Roland
name: Suchowski, Haim
name: Cankaya, Huseyin
name: Kaertner, Franz
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Qing hua tang shi gao : [san juan] [volume 02]
情話堂詩稿 : [三卷] [第二冊]
Creators: name: Min, Ding
name: 閔鼎
Publisher: name: The University of British Columbia
Year: 2018

description: Handwritten copy, on double leaves, East Asian binding.
Edition: [Chao ben]
title: Στάσεις της Σχολικής Ηγεσίας και των Εκπαιδευτικών στη Συμπεριληπτική Εκπαίδευση
title: Attitudes of School Leadership and Teachers το Inclusive Education
titleType: AlternativeTitle
Creators: name: Καστάνη, Καλλιόπη
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Συμπερίληψη
Μαθητές με Ε.ε.α./α.
Εκπαιδευτικοί
Συμπεριληπτική εκπαίδευση
Σχολική ηγεσία

description: Στην παρούσα εργασία γίνεται μια προσπάθεια προσέγγισης της έννοιας της Συμπερίληψης στην Εκπαίδευση (Inclusive Education), μιας έννοιας δύσκολης να συνοψιστεί σε έναν μόνο ορισμό. Ο αυξανόμενος αριθμός μαθητών με ειδικές εκπαιδευτικές ανάγκες ή και αναπηρία την ανάγουν σε πρωταρχική εκπαιδευτική πολιτική που εναρμονίζεται με την προάσπιση των ανθρωπίνων δικαιωμάτων. Για τη μετουσίωση της από όραμα σε πράξη είναι απαραίτητος ο ρόλος της σχολικής ηγεσίας και των εκπαιδευτικών. Οι στάσεις της σχολικής ηγεσίας και των εκπαιδευτικών αποτελούν σημαντικό παράγοντα για μια επιτυχημένη εφαρμογή της συνεκπαίδευσης των μαθητών με ή χωρίς εκπαιδευτικές ανάγκες ή και αναπηρία.
Biochemical Differentiation and Molecular Characterization of Biofield Treated Vibrio parahaemolyticus
Creators: name: Trivedi, Mahendra
Publisher: name: SMN - The ScienceMedia Network
Year: 2016
Subjects: Natural Sciences
Biology

description: The recent emergence of the Vibrio parahaemolyticus (V. parahaemolyticus) is a pandemic. For the safety concern of seafood, consumer monitoring of this organism in seafood is very much essential. The current study was undertaken to evaluate the impact of Mr. Trivedi’s biofield energy treatment on [ATCC-17802] strain of V. parahaemolyticus for its biochemical characteristics, biotype and 16S rDNA analysis. The lyophilized strain of V. parahaemolyticus was divided into two parts, Group (Gr.) I: control and Gr. II: treated. Gr. II was further subdivided into two parts, Gr. IIA and Gr. IIB. Gr. IIA was analyzed on day 10, whereas, Gr. IIB was stored and analyzed on day 142 (Study I). After retreatment of Gr. IIB on day 142 (Study II), the sample was divided into three separate tubes. The tubes first, second and third were analyzed on day 5, 10, and 15, respectively. The biochemical reaction and biotyping were performed using automated MicroScan Walk-Away® system. The 16S rDNA sequencing was carried out to correlate the phylogenetic relationship of V. parahaemolyticus with other bacterial species after the treatment. The results of biochemical reactions were altered 24.24%, out of thirty-three in the treated groups with respect to the control. Moreover, negative (-) reaction of urea was changed to positive (+) in the revived treated Gr. IIB, Study II on day 15 as compared to the control. Besides, biotype number was substantially changed in all the treated groups as compared to the control. However, change in organisms were reported in Gr. IIA on day 10 and in Gr. IIB; Study II on day 5 as Shewanella putrefaciens and Moraxella/Psychrobacter spp., respectively with respect to the control i.e. Vibrio sp. SF. 16S rDNA analysis showed that the identified sample in this experiment was V. parahaemolyticus after biofield treatment, and the nearest homolog genus-species was observed as Vibrio natriegens with 98% gene identity. The results envisaged that the biofield energy treatment showed an alteration in biochemical reaction pattern and biotype number on the strain of V. parahaemolyticus.
title: Attenuation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus as a Vaccine Strategy
Creators: name: Lehman, Caitlin Woodson
Publisher: name: George Mason University
Year: 2020
Subjects: subject: VEEV
subject: Vaccine
subject: Alphavirus
subject: Programmed ribosomal frameshifting

description: This thesis has been embargoed for 2 years and will not be available until September 2020 at the earliest.
description: Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus that is capable of causing significant disease in equines and humans. Moreover, infection with VEEV can be fatal in up to 90% of cases for equines. In humans, while death is rare, infection with VEEV can result in debilitating neurological sequelae. The current vaccines for VEEV are a live-attenuated vaccine (TC-83) and an inactivated form of the vaccine (C-84). However, neither of these are approved by the FDA for human use and only at risk military personnel and laboratorians are vaccinated. We are studying the rational design of VEEV vaccines through mutation of the programmed -1 ribosomal frameshifting (-1 PRF) signal of VEEV. Use of the -1 PRF signal allows production of the viral trans-frame protein of VEEV, which is known to play a role in neuropathogenesis. Our lab recently characterized the -1 PRF signals for alphaviruses and results revealed novel -1 PRF stimulatory structures. While disruption of the -1 PRF signal mildly affected VEEV kinetics in cell culture, it significantly inhibited its pathogenesis in mice challenged subcutaneously or via aerosol. In addition to markedly increased survival, mice exposed to the -1 PRF mutant VEEV (VEEV TrDPRFm) displayed less severe clinical signs and weight loss over the course of infection compared to wild-type (WT) control mice. Serial sacrifice studies indicated mice exposed to VEEV TrDPRFm had either undetectable or reduced levels of virus in the brain, spleen, and serum at all timepoints assayed indicating that dissemination of VEEV TrDPRFm is altered in vivo, resulting in less viral replication and overall decreased pathogenesis. Finally, mice vaccinated with VEEV TrDPRFm developed strong neutralizing antibodies and were protected against lethal challenge with aerosolized VEEV TrD. These studies indicate that targeting translational recoding events such as frameshifting is a potential avenue of inquiry for rational vaccine development.
Yi tong pa guan ci chao
倚銅琶館詞鈔
Creators: name: Wen, Zihao, Active 19th Century
name: 温子顥, 活躍於19世纪
Publisher: name: The University of British Columbia
Year: 2016

description: A manuscript of Wen Zihao's poems.
On double leaves, East Asian binding.
Sealed by Pan Feisheng and Yao Junshi.
Edition: [Gao ben]
Examining structural, systemic, and enabling approaches to sustainable food system transformations
Creators: name: Gibson, Matt
Publisher: name: Imperial College London
Year: 2023

description: Food systems must transform to address global social and ecological crises. However, the nature of this transformation is deeply contested. The effectiveness of research is hampered by the fragmentation of diverse conceptual approaches to food systems transformation. This thesis poses two research questions to contribute to addressing this challenge, employing Scoones et al.’s (2020) structural, systemic, and enabling approaches to transformation. Firstly (RQ1), how do different conceptualisations of transformation compare among food systems policy actors? Secondly (RQ2), what analytical insights can be derived from examining different approaches to food system transformation in isolation and as complementary lenses? RQ1 was addressed with a survey and document analysis of UK and global food systems actors. Mainstream actors (government, agribusiness) typically favoured systemic approaches, whereas alternative actors (civil society, small-scale producers, grassroots entities) had greater focus on structural and enabling approaches. The asymmetric use of certain transformation approaches in government and industry decision-making risks locking in some forms of knowledge at the expense of others. RQ2 was addressed with quantitative and qualitative methods through three case studies that looked at degrowth, food loss, and dietary change. The structural case study demonstrated the broad appeal of degrowth among alternative food system actors, the systemic case study successfully quantified the interaction between energy and nutrition for grain storage losses in India, while the enabling case study showed how the dynamics of individual bottom-up agency can lead to emergent dietary shifts. However, no single approach can adequately respond to the complex challenges of food systems transformation. This thesis supports the need to nurture integrated and pluralistic research by proposing an assessment framework for food systems transformation research. Food systems transformation requires the widest possible analytical and narrative lens with which to navigate pathways to sustainable, healthy, and just food for all.
title: Comparing Traditional Ecological Knowledge and Scientific Census Data on Primate Populations in the Sucusari Community, Peruvian Amazon
Creators: name: Mere, Carla
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Traditional ecological knowledge
subject: Maijuna indigenous people
subject: Primates
subject: Amazon rainforest

description: Similar to other ecosystems around the world, the Amazon rainforest is threatened by a wide variety of anthropogenic activities. The urgent need for conservation often requires arduous, long, and expensive fieldwork. Primates are one of the species most affected by human activities within tropical rainforests mainly due to habitat degradation and hunting pressure. Indigenous people possess valuable knowledge obtained through experience with the environment and passed down through generations, known as traditional ecological knowledge (TEK). The aim of this study was to compare the TEK of the community of Sucusari in the Peruvian Amazon to scientific primate census data, ultimately determining if TEK can be used to help enhance or even replace high cost conservation surveys of primates. Primate diversity, group size, and habitat use of all primate species found during field surveys were compared with data obtained through 50 semi-structured interviews. Transects were performed on a parallel trail system (22 trails that are approximately 4 km each) located within the Sucusari River basin. The results suggest that the reliability of TEK compared to scientific data improves with larger-sized and culturally important primates. In conclusion, TEK is an important tool to enhance high-cost and time-intensive scientific sampling methods, especially for large-bodied primate populations and those significant to local cultural traditions. It should be used cautiously and target local community experts.
Postoperative single-sequence (PoSSe) MRI: imaging work-up for CT-guided or endoscopic drainage indication of collections after hepatopancreaticobiliary surgery
Creators: name: Fehrenbach, Uli
name: Auer, Timo A.
name: Schöning, Wenzel
name: Schmelzle, Moritz
name: Jürgensen, Christian
name: Malinka, Thomas
name: Bahra, Marcus
name: Geisel, Dominik
name: Denecke, Timm
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Magnetic resonance imaging
subject: Abbreviated protocol
subject: Postoperative leakage
subject: Hepatopancreaticobiliary surgery
subject: Drainage
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Fluid collections due to anastomotic leakage are a common complication after hepatopancreaticobiliary (HPB) surgery and are usually treated with drainage. We conducted a study to evaluate imaging work-up with a postoperative single-sequence (PoSSe) MRI for the detection of collections and indication of drainage. Material and methods: Forty-six patients who developed signs of leakage (fever, pain, laboratory findings) after HPB surgery were prospectively enrolled. Each patient was examined by abdominal sonography and our PoSSe MRI protocol (axial T2-weighted HASTE only). PoSSe MRI examination time (from entering to leaving the MR scanner room) was measured. Sonography and MRI were evaluated regarding the detection and localization of fluid collections. Each examination was classified for diagnostic sufficiency and an imaging-based recommendation if CT-guided or endoscopic drainage is reasonable or not was proposed. Imaging work-up was evaluated in terms of feasibility and the possibility of drainage indication. Results: Sonography, as first-line modality, detected 21 focal fluid collections and allowed to decide about the need for drainage in 41% of patients. The average time in the scanning room for PoSSe MRI was 9:23 min [7:50-13:32 min]. PoSSe MRI detected 46 focal collections and allowed therapeutic decisions in all patients. Drainage was suggested based on PoSSe MRI in 25 patients (54%) and subsequently indicated and performed in 21 patients (100% sensitivity and 84% specificity). No patient needed further imaging to optimize the treatment. Conclusions: The PoSSe MRI approach is feasible in the early and intermediate postoperative setting after HPB surgery and shows a higher detection rate than sonography. Imaging work-up regarding drainage of collections was successful in all patients and our proposed PoSSe MRI algorithm provides an alternative to the standard work-up.
Supplementary document for Sidelobe-suppressed sub-diffraction-limit quasi-non-diffracting light sheets achieved by super-oscillatory lenses - 6307324.pdf
Creators: name: He, Pei
name: An, Chengxu
name: ji, haiyu
name: Li, Wenli
name: Yuan, Weizheng
name: Yu, Yiting
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement1
Augmented reality visualization in brain lesions: a prospective randomized controlled evaluation of its potential and current limitations in navigated microneurosurgery
Creators: name: Roethe, Anna L.
name: Rösler, Judith
name: Misch, Martin
name: Vajkoczy, Peter
name: Picht, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Augmented reality
subject: Brain tumors
subject: Intraoperative visualization
subject: Navigated microscope
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Augmented reality (AR) has the potential to support complex neurosurgical interventions by including visual information seamlessly. This study examines intraoperative visualization parameters and clinical impact of AR in brain tumor surgery. Methods: Fifty-five intracranial lesions, operated either with AR-navigated microscope (n = 39) or conventional neuronavigation (n = 16) after randomization, have been included prospectively. Surgical resection time, duration/type/mode of AR, displayed objects (n, type), pointer-based navigation checks (n), usability of control, quality indicators, and overall surgical usefulness of AR have been assessed. Results: AR display has been used in 44.4% of resection time. Predominant AR type was navigation view (75.7%), followed by target volumes (20.1%). Predominant AR mode was picture-in-picture (PiP) (72.5%), followed by 23.3% overlay display. In 43.6% of cases, vision of important anatomical structures has been partially or entirely blocked by AR information. A total of 7.7% of cases used MRI navigation only, 30.8% used one, 23.1% used two, and 38.5% used three or more object segmentations in AR navigation. A total of 66.7% of surgeons found AR visualization helpful in the individual surgical case. AR depth information and accuracy have been rated acceptable (median 3.0 vs. median 5.0 in conventional neuronavigation). The mean utilization of the navigation pointer was 2.6 x /resection hour (AR) vs. 9.7 x /resection hour (neuronavigation); navigation effort was significantly reduced in AR (P < 0.001). Conclusions: The main benefit of HUD-based AR visualization in brain tumor surgery is the integrated continuous display allowing for pointer-less navigation. Navigation view (PiP) provides the highest usability while blocking the operative field less frequently. Visualization quality will benefit from improvements in registration accuracy and depth impression.
title: Η παιδαγωγική διαχείριση της επιλεκτικής αλαλίας στην πρώιμη παιδική ηλικία
title: The pedagogical management of selective mutism in early childhood
titleType: AlternativeTitle
Creators: name: Ράντη, Δήμητρα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Ομιλία
Παιδαγωγός
Περιβάλλον
Άγχος
Στρατηγικές
Επιμόρφωση

description: Η παιδαγωγική διαχείριση της επιλεκτικής αλαλίας στην πρώιμη παιδική ηλικία αποτελεί σημαντικό θέμα στον τομέα της παιδαγωγικής και στην εξέλιξη της γλωσσικής ικανότητας των παιδιών. Η επιλεκτική αλαλία αναφέρεται στην τάση ορισμένων παιδιών να επικοινωνούν με λιγότερα λόγια, να παρουσιάζουν δυσκολίες στην έκφραση των σκέψεων τους ή να προτιμούν να μην εκφράζονται πλήρως σε συγκεκριμένες καταστάσεις. Είναι σημαντικό οι εκπαιδευτικοί να κατανοούν τους λόγους πίσω από την επιλεκτική αλαλία και να αναγνωρίζουν ότι κάθε παιδί είναι μοναδικό και μπορεί να έχει διαφορετικούς λόγους για να μην επικοινωνεί πλήρως. Με την κατάλληλη παιδαγωγική διαχείριση εκ μέρους των εκπαιδευτικών μπορεί να βοηθηθούν τα παιδιά να αναπτύξουν τις γλωσσικές τους ικανότητες και να αισθανθούν πιο άνετα στο να επικοινωνούν με το περιβάλλον τους.
Linear fits of ECA;Fits for PLSSVD from Emulator-based decomposition for structural sensitivity of core-level spectra
Creators: name: Niskanen, J.
name: Vladyka, A.
name: Niemi, J.
name: Sahle, Ch. J.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Computational Physics
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Linear fits to decide the orientation of the first ECA component vectors. Emulator-evaluated intensities on projected points are given together with the known intensity values for the corresponding data point.;Fits for the coefficients ck in the PLSSVD procedure. Scores of the standardized data are given for XES (a-c), for XAS (d-f) and for XPS (g-i) together with a linear fit. The intercept term in the fit equation is negligible.
Neuroendoscopic surgery in neonates — indication and results over a 10-year practice
Creators: name: Schaumann, Andreas
name: Bührer, Christoph
name: Schulz, Matthias
name: Thomale, Ulrich-Wilhelm
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Neuroendoscopy
subject: Neonates
subject: Neuroendoscopic lavage
subject: Posthemorrhagic hydrocephalus
subject: Postinfectious hydrocephalus
subject: Intraventricular hemorrhage
subject: Intraventricular infection
subject: Ventricle peritoneal shunt
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Neuroendoscopic procedures for treatment of term and preterm newborn infants, such as endoscopic lavage for posthemorrhagic hydrocephalus, are gaining popularity despite sparse data. This single-institution report compiles all neuroendoscopic surgical procedures performed in neonates during a 10-year period. Methods: Charts and electronic records were reviewed of all consecutive newborns who underwent a neuroendoscopic procedure before reaching a postmenstrual age of 44 weeks between 09/2010 and 09/2020. Available documentation was reviewed regarding the performed neuroendoscopic procedure, course of disease, complications, and all re-operations throughout the first year of life. Results: During the 10-year study period, 116 infants (median gestational age at birth: 29 (1)/7 weeks) underwent a total of 153 neuroendoscopic procedures (median postmenstrual age at surgery: 35 (0)/7 weeks). The most common indication at the time of the neuroendoscopic procedures (n = 153) was intraventricular hemorrhage (IVH, n = 119), intraventricular infection (n = 15), congenital malformation (n = 8), isolated 4th ventricle (n = 7), multiloculated hydrocephalus (n = 3), and tumor (n = 1). Thirty-eight of 116 children (32.8%) underwent 43 operative revisions after 153 neuroendoscopic procedure (28.1%). Observed complications requiring surgical revision were secondary infection (n = 11), CSF fistula (n = 9), shunt dysfunction (n = 8), failure of ETV (n = 6), among others. 72 children (62%) of 116 children required permanent CSF diversion via a shunt. The respective shunt rates per diagnosis were 47 of 80 (58.8%) for previously untreated IVH, 11 of 13 (84.6%) for intraventricular infection. Shunt survival rate for the first year of life was 74% for the whole cohort. Conclusion: The experience with this large cohort of neonates demonstrates the feasibility of neuroendoscopic technique for the treatment of posthemorrhagic or postinfectious hydrocephalus. Rate and type of complications after neuroendoscopic procedures were within the expected range. Assessing the potential long-term benefits of neuroendoscopic techniques has to await results of ongoing studies.
title: Some Reflections on the Role of Power in Track II Mediation
Creators: name: Hoffman, Evan A.
Publisher: name: Ottawa Dialogue
Year: 2021
Subjects: subject: Mediation
subject: Track II
subject: Diplomacy
subject: Power

description: Power is a central feature of both Track I (formal) and Track II (informal) mediation. Power intersects the mediation process at every stage and is deeply embedded in the process, its design and structure, as well as who facilitates it. This paper addresses the question of how to manage these and other power dynamics and what can be done to alter them. Four key insights are presented based on the author’s personal experience undertaking peacemaking and mediation in Canada and overseas over the last twenty years. The four insights are that: (1) Convening power is shaped by the type of process and who is running it; (2) The mediator has procedural power but exercising it might create a reputational cost; (3) Power imbalances are likely to occur and the mediator needs to make a conscious effort to address them; (4) Power, which is often deeply embedded in the social institutions where the conflict is occurring, can be used for either constructive (peaceful) or destructive (violent) purposes and that decision is influenced by leaders from different sectors (political, military, etc.). Based on these four key insights, several recommendations for mediation and peacemaking actors to address power dynamics are developed.
IMPROVING THE DURABILITY OF MACHINE-BUILDING COMPOSITE POLYMERIC AND PAINT-AND-LACQUER MATERIALS AND COATINGS BY LOWERING INTERNAL STRESSES AND DEVELOPING A TECHNOLOGY FOR THEIR PRODUCTION
Creators: name: Ulmasov, Ahadjon
name: Sayfiyev, Behzod
Publisher: name: Zenodo
Year: 2024

description: The proposed organomineral additives are novel, eco- friendly components for polystyrene paints. A light brown-red loam was used as a filler for polystyrene paints. Rheological, technological and physico-mechanical properties of paints and coatings based on them were studied by a series of standard tests. Characteristics of frost and water resistance, hiding power and holding capacity of polystyrene paint confirmed the creation of durable paints with high performance properties. Comprehensive studies have shown that the addition of organic additives in the composition of polystyrene paint increases the critical volume concentration of pigment 1.2 times, increases the degree of grinding paint, reduces dispersion time (2 times) and reduces the speed of shelter from 160 to 112 g / m2. Analysis of the results of experiments showed that the addition of organic additives contributes to increased resistance to external influences, as well as the strength of adhesion to the substrate by 22 %. Using the obtained results will allow you to create polystyrene paints with a low content of volatile compounds and increased crack resistance.
title: Changes in Snowmelt Runoff Timing in the Contiguous United States, 1957-2016
Creators: name: Uzun, Şükrü
Publisher: name: George Mason University
Year: 2021
Subjects: subject: Snowmelt
subject: Trends
subject: Temperature
subject: Runoff
subject: Climate change
subject: Precipitation

description: Changes in timing and quantity of snowmelt-fed streamflow have great importance for water supply, flood management, and ecological processes, as well as, being a common indicator of climate change. Within this scope, a snowmelt runoff timing analysis covering the contiguous United States with the most recent data is needed. In this study, these changes were investigated by analyzing relatively undisturbed streamflow observations in 97 streamflow gauges for the period between 1957 and 2016. The proposed approach was applied to 6 zones (A, B, C, D, E, and F) from the northeast to southwest of the conterminous US. The annual snowmelt runoff timing shift was identified using ‘Center Time (CT)’ and ‘Spring Pulse Onset (SPO)’ methods, jointly with the analysis of monthly average and fractional streamflow from January to June, which is the time period covering later snow accumulation and snow melting. Since snowmelt-derived streamflow timing change is mainly induced by regional meteorological factors, such as air temperature and precipitation, their trends and relationship with CT were examined. Shifts toward earlier snowmelt runoff timing were found by both methods, CT (85.6% of the stations) and SPO (59.8% of the stations). Widespread average trends in CT and SPO were 8.3 and 8.5 days toward earlier, respectively. Although the results of CT change are stronger than SPO change, both outcomes are mostly correlated, particularly in the central and northwestern parts of the country. Monthly average streamflow and monthly fractional streamflow trends support the outcomes of CT and SPO. In January, February, and especially March, a higher number of the stations indicated increasing trends in monthly fractional streamflow. In April, May, and June, their number decreased and the number of gages with diminishing trends rose sharply. The timing difference is highly related to temperature change. Annual average temperature and temperature in the melting period increases considerably. The annual average temperature is significantly negatively correlated with CT in the vast majority of the regions. Although precipitation is not as effective as the temperature, its trends have impacts on snowmelt runoff timing change depending on the region and elevation. These results demonstrate the importance of the impacts of the changes in snowmelt runoff timing due to global warming on the regional and large-scale hydrology in the contiguous United States.
Di-Gozd Digital Forest Inventory - Mobile app
Creators: name: Gačo, Amina
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity and nature managment
Supply chain
Marketing and consumption
Wood mobilization

description: The mobile app complements the web application, allowing users to register a plot and make five different records. Tree count can be done automatically or manually using augmented reality. It helps estimate wood supply, track felled trees, and manage felling paths for better control.
Dose-dependent effects of insoluble fibre on glucose metabolism: a stratified post hoc analysis of the Optimal Fibre Trial (OptiFiT)
Creators: name: Kabisch, Stefan
name: Honsek, Caroline
name: Kemper, Margrit
name: Gerbracht, Christiana
name: Arafat, Ayman M.
name: Birkenfeld, Andreas L.
name: Dambeck, Ulrike
name: Osterhoff, Martin A.
name: Weickert, Martin O.
name: Pfeiffer, Andreas F. H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Diabetes mellitus type 2
subject: Prediabetes
subject: Diabetes prevention
subject: Impaired fasting glucose
subject: Stratification
subject: Impaired glucose tolerance
subject: Insoluble dietary fibre
subject: Insulin sensitivity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aims: As the first long-term RCT on insoluble cereal fibre, the optimal fibre trial demonstrated glycometabolic benefits, confirming cohort studies. The combined study intervention of lifestyle recommendations and supplementation with insoluble oat hulls fibre allows to clarify, which amount of fibre is required for a beneficial effect. Methods: One hundred and eighty participants with impaired glucose tolerance underwent the one-year PREDIAS lifestyle programme and received a blinded, randomized fibre or placebo supplement for two years. We conducted a regression analyses and cut-off-based tertile comparisons in subjects with full data on dietary compliance (food records and accounted supplement; n = 120) after one year, investigating effects on fasting blood parameters, oral glucose tolerance test and anthropometry. Results: We found a nonlinear inverse relation between fibre intake and change in postprandial 2-h glucose levels, showing a metabolic benefit beyond 14 g and a plateau beyond 25 g of total insoluble fibre per day. 2-h glucose levels improved significantly stronger in both upper tertiles (-0.9 [-1.6;-0.2] mmol/l, p = 0.047, and -0.6 [-1.6;0.3] mmol/l, p = 0.010) compared to the lowest tertile (0.1 [-1.2;1.1] mmol/l), also when adjusted for changes in bodyweight. Subjects with the highest fibre intake showed superior effects on fasting and postprandial insulin resistance, hepatic insulin clearance, leucocyte count and fatty liver index. Conclusions:578000912362 578000912362 578000912362 Extending the knowledge on the benefits of insoluble oat hulls fibre, our post hoc analysis demonstrates a dose effect for glycaemia and associated metabolic markers. Further research is needed in order to replicate our findings in larger trials.
title: Adaptive Anchoring Discretization for Learnable Evolution Model: The ANCHOR Method
Creators: name: Michalski, Ryszard S.
name: Cervone, Guido
Publisher: name: George Mason University
Year: 2001

description: To apply a symbolic learning method to learning in a continuous representation space, the variables spanning the space need to be discretized. When the space is very large, a problem arises as to how to determine a discretization scheme for each variable that is both efficient and effective. This task is particularly important when applying Learnable Evolution Model to optimization problems with very large number of continuous variables. The presented method, called ANCHOR, starts with a low discretization precision of the variables, and then increases the discretization precision in the subranges indicated by the analysis of the descriptions learned using a lower precision. The method has been incorporated in the LEM2 system implementing the Learnable Evolution Model. Experiments with ANCHOR have demonstrated a significant advantage of the method over a fixed discretization method, and enabled LEM2 to optimize functions of large number of continuous variables very effectively.
Physical, Atomic and Thermal Properties of Biofield Treated Lithium Powder
Creators: name: Trivedi, Mahendra
Publisher: name: SMN - The ScienceMedia Network
Year: 2016
Subjects: Natural Sciences
Chemistry

description: Lithium has gained extensive attention in medical science due to mood stabilizing activity. The objective of the present study was to evaluate the impact of biofield treatment on physical, atomic, and thermal properties of lithium powder. The lithium powder was divided into two parts i.e., control and treatment. Control part was remained as untreated and treatment part received Mr. Trivedi’s biofield treatment. Subsequently, control and treated lithium powder samples were characterized using X-ray diffraction (XRD), Differential scanning calorimetry (DSC), Thermogravimetric analysis-differential thermal analysis (TGA-DTA), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). XRD data showed that lattice parameter, unit cell volume, density, atomic weight, and nuclear charge per unit volume of lithium were altered after biofield treatment. The crystallite size of treated lithium was increased by 75% as compared to control. DSC analysis exhibited an increase in melting temperature of treated lithium powder upto 11.2% as compared to control. TGA-DTA analysis result showed that oxidation temperature, which found after melting point, was reduced upto 285.21°C in treated lithium as compared to control (358.96°C). Besides, SEM images of control and treated lithium samples showed the agglomerated micro particles. Moreover, FT-IR analysis data showed an alteration in absorption band (416→449 cm-1) in treated lithium sample after biofield treatment as compared to control. Overall, data suggested that biofield treatment has significantly altered the physical, atomic, and thermal properties of lithium powder.
2D Patterned Ion-Exchange Membranes Induce Electroconvection
Creators: name: Wessling, Matthias
Publisher: name: figshare
Year: 2022
Subjects: subject: 90404 Membrane and Separation Technologies
subject: FOS: Chemical engineering

description: Concentration polarization is a diffusion-limited phenomenon for ion transport in electrodialysis based desalination processes. Once a so-called limiting current is reached, the resistance of the system rises notably manifested as a plateau region in the current-voltage curves. For long it is hypothesized that altering the surface properties of the membrane can overcome the diffusional transport limitation by the induction of electroconvective vortices mixing up the laminar boundary layer. To systematically investigate the influence of geometrical and chemical membrane surface topology on the evolution of electroconvection, circular patterns of polystyrene, poly (2-vinylpyridine) and P2VP-microgels were inkjet printed on cation-exchange membranes. All types of patterns cause an insignificant increase in membrane resistance but they reduce the plateau lengths indicating the desired accelerated onset of electroconvection. In case of PS patterns, the drop in plateau length results in a small reduction in transport resistance for overlimiting currents. However, membranes modified with linear P2VP and P2VP microgel patterns do exhibit significantly decreased resistance in this region at a simultaneous increase of the limiting current density. Direct numerical simulations support our interpretation that the surface charge of the printed patterns influences the direction of the vortices being advantageous during ion transport towards the membrane.
title: Practical handling of allergic reactions to COVID-19 vaccines
title: A position paper from German and Austrian Allergy Societies AeDA, DGAKI, GPA and ÖGAI
titleType: Subtitle
Creators: name: Klimek, Ludger
name: Bergmann, Karl-Christian
name: Brehler, Randolf
name: Pfützner, Wolfgang
name: Zuberbier, Torsten
name: Hartmann, Karin
name: Jakob, Thilo
name: Novak, Natalija
name: Ring, Johannes
name: Merk, Hans
name: Hamelmann, Eckard
name: Ankermann, Tobias
name: Schmidt, Sebastian
name: Untersmayr, Eva
name: Hötzenecker, Wolfram
name: Jensen-Jarolim, Erika
name: Brockow, Knut
name: Mahler, Vera
name: Worm, Margitta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Allergic reaction
subject: Anaphylactic reaction
subject: Corona virus
subject: Safety
subject: Vaccination
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: For the preventive treatment of the 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied the safety and efficacy of new vaccine platforms that have not been previously used in humans. Less than one year after the discovery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral sequence, these vaccines were approved for use in the European Union (EU) as well as in numerous other countries and mass vaccination efforts began. The so far in the EU approved mRNA vaccines BNT162b2 and mRNA-1273 are based on similar lipid-based nanoparticle carrier technologies; however, the lipid components differ. Severe allergic reactions and anaphylaxis after COVID-19 vaccination are very rare adverse events but have drawn attention due to potentially lethal outcomes and have triggered a high degree of uncertainty. Methods: Current knowledge on anaphylactic reactions to vaccines and specifically the new mRNA COVID-19 vaccines was compiled using a literature search in Medline, PubMed, as well as the national and international study and guideline registries, the Cochrane Library, and the Internet, with special reference to official websites of the World Health Organization (WHO), US Centers for Disease Control and Prevention (CDC), Robert Koch Institute (RKI), and Paul Ehrlich Institute (PEI). Results: Based on the international literature and previous experience, recommendations for prophylaxis, diagnosis and therapy of these allergic reactions are given by a panel of experts. Conclusion: Allergy testing is not necessary for the vast majority of allergic patients prior to COVID-19 vaccination with currently licensed vaccines. In case of allergic/anaphylactic reactions after vaccination, allergy workup is recommended, as it is for a small potential risk population prior to the first vaccination. Evaluation and approval of diagnostic tests should be done for this purpose.
Supplementary document for Spectral properties of intermediate to high refractive index nanocubes - 6307515.pdf
Creators: name: Madeleine, Tristan
name: D'Alessandro, Giampaolo
name: Kaczmarek, Malgosia
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1 contains the emission efficiency of generic NPA and the influence of the gap thickness
title: Supporting and Preparing Future Decision-makers with the Needed Tools
Creators: name: Wolf-Branigin, Michael
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Non-parametric
subject: Small samples
subject: Decision-making
subject: Complexity
subject: Repeated measures

description: Educational and social service researchers and evaluators continue to develop advanced statistical methods. To ensure that our students have the essential skills as they enter direct service, the focus must be on assuring that they learn readily understandable methods that are appropriate for small samples and use repeated measures.