cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients
Creators: name: Räth, Ulrich
name: Mester, Patricia
name: Schwarz, Herbert
name: Schmid, Stephan
name: Müller, Martina
name: Buechler, Christa
name: Pavel, Vlad
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: sCD137; COVID-19; sepsis; bacterial infection; survival
subject: 610 Medizin

description: T cell depletion and functional impairment are characteristics of sepsis. CD137 is a costimulatory
receptor on activated T cells, while soluble CD137 (sCD137) inhibits CD137 signaling. This
study found elevated sCD137 levels in the plasma of patients with systemic inflammatory response
syndrome (SIRS), sepsis, or septic shock compared to healthy controls. The sCD137 levels negatively
correlated with the C-reactive protein and positively with procalcitonin and interleukin-6. There
was no difference in sCD137 levels based on ventilation, dialysis, or vasopressor treatment. Patients
with SARS-CoV-2, Gram-positive, or Gram-negative bacterial infections had similar sCD137 levels
as noninfected individuals. Notably, higher plasma sCD137 levels were observed in non-survivors
compared to survivors in both the SIRS/sepsis group and the SARS-CoV-2 subgroup. In conclusion,
plasma sCD137 levels are associated with severe illness and survival in critically ill patients.
Quanta fortuna? Machiavelli e il dilemma della contingenza
Creators: name: Magni, Beatrice
Publisher: name: Spazio Filosofico
Year: 2014

description: The register of political actions situates itself, for Machiavelli, in the relation between virtue and fortune. Fortune is that which escapes, it is the configuration given in a specific moment to the conflict that devastates the political space, namely the conflict between the many, who do not want to be dominated, and the great, who want to dominate. Fortune can be anticipated, used, but never ruled. This is a central idea in Machiavelli’s reflection. We can attribute to human existence an excellence that is such insofar as existence is frail, intrinsically and constitutively subject to fortune (and insofar as individuals will then be able to act on fortune and free themselves from its influences via virtue). Because human excellence is such precisely because of its fundamental exposure to fortune, the political theory sought by Machiavelli is one capable of sustaining political unpredictability, contingency, and human condition. Our exposure to fortune and our sense of values make us independent from that which lies outside us. Within the tension between politics and contingency, the general question is: With how much fortune can we humanly coexist? With how much fortune must we coexist so that our life can be the best and most valid?
description: Spazio Filosofico, 12. Fortuna
Fine-tuning the antigen sensitivity of CAR T cells: emerging strategies and current challenges
Creators: name: Harrer, Dennis Christoph
name: Li, Sin-Syue
name: Kaljanac, Marcell
name: Barden, Markus
name: Pan, Hong
name: Abken, Hinrich
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: CAR, antigen downregulation, antigen escape, antigen sensitivity, targeting selectivity
subject: 610 Medizin

description: Chimeric antigen receptor (CAR) T cells are “living drugs” that specifically
recognize their target antigen through an antibody-derived binding domain
resulting in T cell activation, expansion, and destruction of cognate target
cells. The FDA/EMA approval of CAR T cells for the treatment of B cell
malignancies established CAR T cell therapy as an emerging pillar of modern immunotherapy. However, nearly every second patient undergoing CAR T cell therapy is suffering from disease relapse within the first two years which is thought to be due to downregulation or loss of the CAR target antigen on cancer cells, along with decreased functional capacities known as T cell exhaustion.
Antigen downregulation below CAR activation threshold leaves the T cell silent, rendering CAR T cell therapy ineffective. With the application of CAR T cells for the treatment of a growing number of malignant diseases, particularly solid tumors, there is a need for augmenting CAR sensitivity to target antigen present at low densities on cancer cells. Here, we discuss upcoming strategies and current challenges in designing CARs for recognition of antigen low cancer cells, aiming at augmenting sensitivity and finally therapeutic efficacy while reducing the risk of tumor relapse.
Graomys domorum
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Graomys
Graomys domorum

description: Graomys domorum (Thomas 1902)
[Graomys] domorum (Thomas 1902), Ann. Mag. Nat. Hist., ser. 7, 9: 132.
Type Locality: Bolivia, Cochabamba Dept., Tapacari, 3000 m.
Vernacular Names: Pale Pericote.
Synonyms:.
Distribution: E slopes of Andes in SC Bolivia (600-3700 m) and NW Argentina.
Conservation: IUCN – Lower Risk (lc).
Discussion: Maintained as species by Cabrera (1961), but ranked as a subspecies of griseoflavus by Hershkovitz (1962). Chromosomal divergence reported by Pearson and Patton (1976), who reinstated domorum as a species (also see Olds et al., 1987). Reig (1978) followed Cabrera (1961) in allocating taterona to G. domorum, and Anderson (1997) maintained the latter as a definable subspecies.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1117, DOI: 10.5281/zenodo.7316535
Luck and Institutions: A Defense of Institutional Luck Egalitarianism
Creators: name: Tan, Kok-Chor
Publisher: name: Spazio Filosofico
Year: 2014

description: Luck egalitarianism is a picture of distributive equality which holds that a just distributive allocation of the goods or resources (that we take to matter) must reflect the choices of people and not their bad or good luck. Critics of luck egalitarianism have mounted powerful arguments in the form of a reductio ad absurdum against it. For example, one criticism charges that luck egalitarianism has an absurdly and untenably broad reach, such that it must be in the business of mitigating bad luck as it affects persons in all aspects of life. In response to this and other criticisms, I have proposed a restrictive view of luck egalitarianism, one of whose features is its limited institutional focus. On this institutional approach, luck egalitarianism is concerned primarily with how institutions handle good or bad luck, and not with all matters of luck per se. In this discussion, I further clarify this institutional approach to luck egalitarianism and defend its plausibility by replying to some objections.
description: Spazio Filosofico, 12. Fortuna
title: Activité du port de Saint-Malo – 1732 – Le Sud, non localisé
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: matériaux de construction
subject: produits agroalimentaires
subject: alcool
subject: minerais et métaux

description: Marchandises au départ de Saint-Malo : ardoises ; vin ; fer
description: Catégories de marchandises au départ de Saint-Malo : matériaux de construction ; produits agroalimentaires ; alcool ; minerais et métaux
description: Marchandises arrivées à Saint-Malo : cidre ; bois
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; alcool ; matériaux de construction
description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1732 avec le port "Le Sud"
description: Coverage: Petit cabotage
description: Bibliographic citation: PERSEHAIE, Claire. Le Commerce malouin en 1732. DES : Histoire : Rennes : s.d. (Bibliothèque François-Lebrun, MH 1028)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Chrysin and Lentinan Co-Treatment Induces Apoptosis and Ferroptosis by Regulating Metabolic, Apoptotic and Immune-System related Proteins in Human Glioblastoma
Creators: name: ATIQ, AYESHA
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310205
subject: Proteomics and metabolomics
classificationCode: 321108
subject: Molecular targets

description: The standard therapy for glioblastoma lead to fatalities, underscoring the need for more effective treatments. Natural products such as chrysin and lentinan, hold promise as anti-cancer agents. Their combined potential that may offer as a better anti-cancer agents remains unexplored. Current study evaluated the anti-cancer effects of chrysin and lentinan combination in A-172 and T98G GBM cells. The findings describe the synergistic cell death effects of chrysin and lentinan through activation of apoptosis which further leads to ferroptosis induction in GBM cells. Proteomics analysis reveals that the enhancement of metabolism and immune system contributes to apoptosis and ferroptosis-mediated cell death
Graomys edithae Thomas 1919
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Graomys
Graomys edithae

description: Graomys edithae Thomas 1919
Graomys edithae Thomas 1919, Ann. Mag. Nat. Hist., ser. 9, 3: 495.
Type Locality: Argentina, Catamarca Prov., Otro Cerro, 3000 m.
Vernacular Names: Otro Cerro Pericote.
Distribution: Known only from the type locality.
Conservation: IUCN – Lower Risk (lc).
Discussion: Status uncertain—placed as a full synonym of griseoflavus medius (Cabrera, 1961); retained as a nominal species of Phyllotis (Hershkovitz, 1962) or of Graomys (Gyldenstolpe, 1932; Mares et al., 1997; Myers, 1977; Williams and Mares, 1978); or considered a nomen dubium (Galliari et al., 1996). Thomas’ (1919) measurements certainly characterize G. edithae as a smaller form than cachinus and medius, taxa collected at lower elevations in the region of Otro Cerro and now regarded as examples of the larger G. griseoflavus. Reinvestigation of original type series, along with altitudinal transects across vegetation zones in the region, would shed much light. Using an old map (1893) of Catamarca Province, as cited by Cabrera (1961:487), Pardiñas (pers. com.) located the type locality Otro Cerro in the Sierra de Ambato, Capayán Dept., ca. 31.5 km W Huillapima and 16.5 km NNW Chumbicha; formal amendment should be effected in a revisionary context.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1117, DOI: 10.5281/zenodo.7316535
Phasmatodea Jacobson & Bianchi 1902
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Phasmatodea

description: ORDER PHASMATODEA
Tracheal architecture of stick insects has most recently been investigated by Strauss (2021), with an emphasis on the prothorax and possible adaptations for sound reception. Here, three specimens were scanned: the basal Timema cf. californicum, the popular Australian stick insect Extatsoma tiaratum, and the Vietnamese stick insect Medauroidea extra- dentata. Although many basal taxa exhibit synapo- morphies found in sister taxa of a given monophyletic group, Timema exhibits numerous apomorphies and its tracheal system is quite distinct from Extatosoma and Medauroidea. Medauroidea appears to be more representative of the larger phas- mids, with good scan quality and characters that appear to be common to Extatosoma (which is more complex and somewhat harder to homolo- gize). Timema and Medauroidea are described here in detail; Extatosoma is covered here in a more basic fashion due to the substantial complexity in the abdomen. Future studies should focus on the unique morphology of the abdominal tracheae—resem- bling the jumble of dried, packaged ramen noo- dles—of Extatosoma and its possible functions.
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
MODERN LESS INVASIVE METHODS IN THE TREATMENT OF ACUTE CHOLECYSTITIS AGAINST THE BACKGROUND OF CARDIOVASCULAR PATHOLOGIES
Creators: name: Ruziev, O'ktam
Publisher: name: Zenodo
Year: 2024

description: This article discusses modern, less invasive methods for treating acute cholecystitis in patients with cardiovascular diseases. The presence of cardiovascular comorbidities in patients with acute cholecystitis complicates treatment, increasing the risk of postoperative complications and mortality. Minimally invasive interventions such as laparoscopic cholecystectomy and endoscopic techniques have been shown to reduce these risks while offering similar effectiveness to traditional surgical approaches. The article explores these modern methods, focusing on their safety, effectiveness, and improved recovery outcomes for patients with combined acute cholecystitis and cardiovascular diseases.
Serum Metabolomic Profiling of Patients with Lipedema
Creators: name: Kempa, Sally
name: Buechler, Christa
name: Föh, Bandik
name: Felthaus, Oliver
name: Prantl, Lukas
name: Günther, Ulrich L.
name: Müller, Martina
name: Derer-Petersen, Stefanie
name: Sina, Christian
name: Schmelter, Franziska
name: Tews, Hauke Christian
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: metabolomics; lipedema; 1H-nuclear magnetic resonance spectroscopy; 1H-NMR; adipose tissue
subject: 610 Medizin

description: Lipedema is a chronic condition characterized by disproportionate and symmetrical enlargement of adipose tissue, predominantly affecting the lower limbs of women. This study investigated the use of metabolomics in lipedema research, with the objective of identifying complex metabolic disturbances and potential biomarkers for early detection, prognosis, and treatment strategies. The study group (n = 25) comprised women diagnosed with lipedema. The controls were 25 lean women and 25 obese females, both matched for age. In the patients with lipedema, there were notable changes in the metabolite parameters. Specifically, lower levels of histidine and phenylalanine were observed, whereas pyruvic acid was elevated compared with the weight controls. The receiver operating characteristic (ROC) curves for the diagnostic accuracy of histidine, phenylalanine, and pyruvic acid concentrations in distinguishing between patients with lipedema and those with obesity but without lipedema revealed good diagnostic ability for all parameters, with pyruvic acid being the most promising (area under the curve (AUC): 0.9992). Subgroup analysis within matched body mass index (BMI) ranges (30.0 to 39.9 kg/m2) further revealed that differences in pyruvic acid, phenylalanine, and histidine levels are likely linked to lipedema pathology rather than BMI variations. Changes in low-density lipoprotein (LDL)-6 TG levels and significant reductions in various LDL-2-carried lipids of patients with lipedema, compared with the lean controls, were observed. However, these lipids were similar between the lipedema patients and the obese controls, suggesting that these alterations are related to adiposity. Metabolomics is a valuable tool for investigating lipedema, offering a comprehensive view of metabolic changes and insights into lipedema’s underlying mechanisms.
title: Activité du port de Saint-Malo – 1753 – Cowes, Île de Wight
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: céréales
subject: produits combustibles

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1753 avec le port "Ile de Wight Cowes"
description: Marchandises arrivées à Saint-Malo : froment ; farine ; charbon de terre
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; céréales ; produits combustibles
description: Coverage: Grand commerce
description: Bibliographic citation: LE GALL, Jacqueline. Activités du port de Saint-Malo en 1753. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1044)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Wenzel, Gerhard: Das Geheimnis der zwei Kronen ; Strzelecka, Kinga: Maksymilian M. Kolbe
Creators: name: Endres, G.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Magnetic Resonance Image Findings and Potential Anatomic Risk Factors for Chodromalacia in Children and Adolescents Suffering from Non-Overload Atraumatic Knee Pain in the Ambulant Setting
Creators: name: Bäumler, Wolf
name: Popp, Daniel
name: Ostheim, Patrick
name: Dollinger, Marco
name: Senk, Karin
name: Weber, Johannes
name: Stroszczynski, Christian
name: Schaible, Jan
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: MRI; knee pain; atraumatic; non overload; children; adolescents; chondromalacia patellae
subject: 610 Medizin

description: Purpose: To evaluate magnetic resonance image (MRI) findings in children and adolescents suffering from knee pain without traumatic or physical overload history and to identify potential anatomic risk factors. Material and Methods: A total of 507 MRIs of 6- to 20-year-old patients (251 males; 256 females) were evaluated with regard to detectable pathologies of the knee. The results were compared to a control group without pain (n = 73; 34 males; 39 females). A binary logistic regression model and t-tests for paired and unpaired samples were used to identify possible risk factors and significant anatomic differences of the study population. Results: In 348 patients (68.6%), at least one pathology was detected. The most commonly detected finding was chondromalacia of the patellofemoral (PF) joint (n = 205; 40.4%). Chondral lesions of the PF joint occurred significantly more often in knee pain patients than in the control group (40% vs. 11.0%; p = 0.001), especially in cases of a patella tilt angle > 5° (p ≤ 0.001), a bony sulcus angle > 150° (p = 0.002), a cartilaginous sulcus angle > 150° (p = 0.012), a lateral trochlear inclination < 11° (p ≤ 0.001), a lateralised patella (p = 0.023) and a Wiberg type II or III patella shape (p = 0.019). Moreover, a larger patella tilt angle (p = 0.021), a greater bony sulcus angle (p = 0.042), a larger cartilaginous sulcus angle (p = 0.038) and a lower value of the lateral trochlear inclination (p = 0.014) were detected in knee pain patients compared to the reference group. Conclusion: Chondromalacia of the PF joint is frequently observed in children and adolescents suffering from non-overload atraumatic knee pain, whereby a patella tilt angle > 5°, a bony sulcus angle > 150°, a cartilaginous sulcus angle > 150°, a lateral trochlear inclination < 11°, a lateralised patella and a Wiberg type II or III patella shape seem to represent anatomic risk factors.
Graomys griseoflavus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Graomys
Graomys griseoflavus

description: Graomys griseoflavus (Waterhouse 1837)
[Mus] griseoflavus Waterhouse 1837, Proc. Zool. Soc. Lond., 1837: 28.
Type Locality: Argentina, Río Negro Prov., mouth of Río Negro.
Vernacular Names: Common Pericote.
Synonyms: Graomys cachinus (J. A. Allen 1901); Graomys chacoensis (J. A. Allen 1901); Graomys lockwoodi Thomas 1918; Graomys medius Thomas 1919.
Distribution: SC Bolivia, W Paraguay, and nearby Brazil, south through W Argentina to S Chubut Prov.
Conservation: IUCN – Lower Risk (lc).
Discussion: See remarks under G. centralis and G. domorum, taxa formerly included under G. griseoflavus as revised by Hershkovitz (1962). Pardiñas (1995) reallocated the late Pleistocene forms Bothriomys catenatus and Oxymicterus impexus, described by Ameghino (1889), as full synonyms of G. griseoflavus; these reallocations and other fossil sites in Buenos Aires establish the broader distribution of the species in the late Pleistocene.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1117, DOI: 10.5281/zenodo.7316535
Alterna fortuna. Sul dispendio del “più minuto popolo”
Creators: name: Dotti, Marco
Publisher: name: Spazio Filosofico
Year: 2014

description: Between the end of the nineteenth and the first years of the twentieth century, there have been various analyses (of a juridical, fiscal, psychological, social, empathic-literary, moralizing or more properly philosophical nature) concerning the pathological drifts of gambling. Gambling appears as a surrogate for fortune, but also for election and grace once they are inserted in a more modern context for the use of the masses. Balzac spoke of the lottery as “opium for misery” (“opium de la misère”), Karl Marx told of that very same misery defining it as typical of subjects with no possibility for redemption, the Lumpenproletariat. Perhaps more naively and yet not without its own depth, while addressing Naples as an experimentum crucis for a Europe that wished to be considered modern ahead of its times, Matilde Serao spoke of the lottery as a counterpart to the brandy that numbs the working class in Manchester and London. Raising the bar, Serao also spoke of the lottery as “spiritual cholera” and noted that not only paltry people, that is, the miserable or wretched proletariat despised by Marx was seduced by the ritualism and temporality of gambling; even the upper and idle classes (such as judges and notable people) and the hardworking members of the emerging financial capitalism (such as stockbrokers) were affected by it. This brings us back to the often unaddressed question that is central especially to George Bataille’s and Roger Caillois’ reflections, namely: gambling as “production of sacred things,” as sacrificial ritualism where fortune coincides with the very instant and space of such sacrifice.
description: Spazio Filosofico, 12. Fortuna
Exoprosopa fissicornis Bezzi 1924
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Exoprosopa
Exoprosopa fissicornis

description: Exoprosopa fissicornis Bezzi, 1924
(Fig. 24)
95. Exoprosopa (Exoprosopa) fissicornis 1Ψ Tanzania: Mto­ya­Kifaru, 5–10.xii.1904 (Katona). MS page [94].
Bezzi, 1924: 350 – key and diagnosis; 1ɗ Kenya: Serengeti Plains, Mbuyuni, 24.v.1916 (T.J. Anderson) in BMNH.
Greathead, 2001a: 141 – BMNH syntype examined; key to species group, diagnosis and figures from Kenya specimens.
Evenhuis & Greathead, 1999: 361 – listed one syntype in BMNH.
Types: The syntype in HNHM was destroyed. The syntype in BMNH from Kenya is the only surviving syntype and is here designated lectotype (Fig. 24).
Remarks: Exoprosopa fissicornis is readily recognised by the bifurcation at the apex of the antenna. Greathead (2001a) provided a detailed diagnosis that supplements the characters in Bezzi (1924).
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 39, DOI: 10.5281/zenodo.158466
Determination of glomerular filtration rate “en passant” after high doses of iohexol for computed tomography in intensive care medicine—a proof of concept
Creators: name: Dejaco, Alexander
name: Dorn, Christoph
name: Paal, Michael
name: Gruber, Michael
name: Graf, Bernhard M.
name: Kees, Martin G.
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: measured glomerular filtration rate (mGFR), estimated glomerular filtration rate (eGFR), intensive care medicine (ICM), contrast-enhanced computed tomography imaging, “en passant” iohexol clearance, pharmacokinetic studies
subject: 500 Naturwissenschaften
subject: 610 Medizin
subject: 615 Pharmazie

description: Accurate assessment of renal function is of great clinical and scientific importance, as it is an important pharmacokinetic covariate of pivotal drugs. The iohexol clearance is nearly identical to the glomerular filtration rate, but its determination usually requires an intravenous injection and therefore bears intrinsic risks. This motivates to showcase an “en passant” approach to quantification of renal function without additional risk or blood sampling beyond routine care using real-world data. We enrolled 37 intensive care patients who received high doses of iohexol for computed tomography imaging, and quantified series of iohexol plasma concentrations by high-performance liquid chromatography (HPLC-UV). Iohexol clearance was derived by both log-linear regression and nonlinear least squares fitting and compared to glomerular filtration rate estimated by the CKD-EPI-2021 formulas. Nonlinear fitting not only turned out to be more accurate but also more robust in handling the irregularly timed data points. Concordance of iohexol clearance against estimations based on both creatinine and cystatin C showed a slightly higher bias (−3.44 mL/min/1.73 m2) compared to estimations based on creatinine alone (−0.76 mL/min/1.73 m2), but considerably narrower limits of agreement (±42.8 vs. 56 mL/min/1.73 m2) and higher Lin’s correlation (0.84 vs. 0.72). In summary, we have demonstrated the feasibility and performance of the “en passant” variant of the iohexol method in intensive care medicine and described a working protocol for its application in clinical practice and pharmacologic studies.
Both coiling and clipping induce the time-dependent release of endogenous neuropeptide Y into serum
Creators: name: Bründl, Elisabeth
name: Proescholdt, Martin A.
name: Schödel, Petra
name: Rosengarth, Katharina
name: Störr, Eva-Maria
name: Bele, Sylvia
name: Kieninger, Martin
name: Malsy, Manuela
name: Schmidt, Nils Ole
name: Schebesch, Karl-Michael
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: biomarker, cerebrovascular manipulation, clip, coil, cognition, neuropeptide Y (NPY), outcome, unruptured intracranial aneurysms (UIA)
subject: 610 Medizin

description: Background: 
The vaso- and psychoactive endogenous Neuropeptide
Y (NPY) has repeatedly been shown to be excessively released after
subarachnoid hemorrhage and in numerous psychiatric disorders. NPY is
stored in sympathetic perivascular nerve fibers around the major cerebral
arteries. This prospective study was designed to analyze the impact of
microsurgical and endovascular manipulation of the cerebral vasculature
versus cranio- and durotomy alone on the serum levels of NPY.
Methods: 
58 patients (drop-out n = 3; m:f = 26:29; mean age
52.0 ± 14.1 years) were prospectively enrolled. The vascular group
underwent repair for unruptured intracranial aneurysms (UIA) of the
anterior circulation [endovascular aneurysm occlusion (EV) n = 13;
microsurgical clipping (MS) n = 17]; in the non-vascular group, 14
patients received microsurgical resection of a small-sized convexity
meningioma (CM), and 11 patients with surgically treated degenerative
lumbar spine disease (LD) served as control. Plasma was drawn (1)
before treatment (t0), (2) periprocedurally (t1), (3) 6 h postprocedurally
(t2), (4) 72 h postprocedurally (t3), and (5) at the 6-week follow-up (FU;
t4) to determine the NPY levels via competitive enzyme immunoassay in
duplicate serum samples. We statistically evaluated differences between
groups by calculating one-way ANOVA and for changes along the time
points using repeated measure ANOVA.
Results: 
Except for time point t0, the serum concentrations of NPY
ranged significantly higher in the vascular than in the non-vascular
group (p < 0.001), with a slight decrease in both vascular subgroups 6 h
postprocedurally, followed by a gradual increase above baseline levels
until FU. At t3, the EV subgroup showed significantly higher NPY levels
(mean ± standard deviation) than the MS subgroup (0.569 ± 0.198 ng/
mL vs. 0.415 ± 0.192 ng/mL, p = 0.0217). The highest NPY concentrations
were measured in the EV subgroup at t1, t3, and t4, reaching a climax at
FU (0.551 ± 0.304 ng/mL).
Conclusion: 
Our study reveals a first insight into the short-term
dynamics of the serum levels of endogenous NPY in neurosurgical and
endovascular procedures, respectively: Direct manipulation within but also next to the major cerebral arteries induces an excessive release of NPY into the serum. Our findings raise the interesting question of the potential capacity of NPY in modulating the psycho-behavioral outcome of neurovascular patients
Transgene expression knock-down in recombinant Modified Vaccinia virus Ankara vectors improves genetic stability and sustained transgene maintenance across multiple passages
Creators: name: Neckermann, Patrick
name: Mohr, Madlen
name: Billmeier, Martina
name: Karlas, Alexander
name: Boilesen, Ditte R.
name: Thirion, Christian
name: Holst, Peter J.
name: Jordan, Ingo
name: Sandig, Volker
name: Asbach, Benedikt
name: Wagner, Ralf
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: MVA, poxviral vectors, Modified Vaccinia Ankara, transgene stability, transgene knockdown, viral vaccines, vaccine manufacturing, transgene maintenance
subject: 610 Medizin

description: Modified vaccinia virus Ankara is a versatile vaccine vector, well suited for transgene delivery, with an excellent safety profile. However, certain transgenes render recombinant MVA (rMVA) genetically unstable, leading to the accumulation of mutated rMVA with impaired transgene expression. This represents a major challenge for upscaling and manufacturing of rMVA vaccines. To prevent transgene-mediated negative selection, the continuous avian cell line AGE1.CR pIX (CR pIX) was modified to suppress transgene expression during rMVA generation and amplification. This was achieved by constitutively expressing a tetracycline repressor (TetR) together with a rat-derived shRNA in engineered CR pIX PRO suppressor cells targeting an operator element (tetO) and 3’ untranslated sequence motif on a chimeric poxviral promoter and the transgene mRNA, respectively. This cell line was instrumental in generating two rMVA (isolate CR19) expressing a Macaca fascicularis papillomavirus type 3 (MfPV3) E1E2E6E7 artificially-fused polyprotein following recombination-mediated integration of the coding sequences into the DelIII (CR19 M-DelIII) or TK locus (CR19 M-TK), respectively. Characterization of rMVA on parental CR pIX or engineered CR pIX PRO suppressor cells revealed enhanced replication kinetics, higher virus titers and a focus morphology equaling wild-type MVA, when transgene expression was suppressed. Serially passaging both rMVA ten times on parental CR pIX cells and tracking E1E2E6E7 expression by flow cytometry revealed a rapid loss of transgene product after only few passages. PCR analysis and next-generation sequencing demonstrated that rMVA accumulated mutations within the E1E2E6E7 open reading frame (CR19 M-TK) or deletions of the whole transgene cassette (CR19 M-DelIII). In contrast, CR pIX PRO suppressor cells preserved robust transgene expression for up to 10 passages, however, rMVAs were more stable when E1E2E6E7 was integrated into the TK as compared to the DelIII locus. In conclusion, sustained knock-down of transgene expression in CR pIX PRO suppressor cells facilitates the generation, propagation and large-scale manufacturing of rMVA with transgenes hampering viral replication.
Sartory, Gertrude und Thomas: Benedikt von Nursia - Weisheit des Maßes ; Nigg, Walter: Lehrmeister der Christenheit in verwirrter Zeit
Creators: name: Gnandt, Georg
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Handleyomys Voss, Gómez-Laverde, and Pacheco 2002
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Handleyomys

description: Handleyomys Voss, Gómez-Laverde, and Pacheco 2002
Handleyomys Voss, Gómez-Laverde, and Pacheco 2002, Am. Mus. Novit., 3373: 5.
Type Species: Aepeomys fuscatus J. A. Allen 1912
Species and subspecies: 2 species:
Species Handleyomys fuscatus (J. A. Allen 1912)
Species Handleyomys intectus (Thomas 1921)
Discussion: Oryzomyini. The two species, fuscatus and intectus, composing this new genus had been recognized as problematic members within their genera of original description, Aepeomys and Oryzomys respectively (e.g., Gardner and Patton, 1976; Musser and Carleton, 1993; Ochoa et al., 2001). Discrimination from those genera, morphological description, distribution, and ecological information supplied by Voss et al. (2002). Females lack pectoral mammae as common to most oryzomyine species (see Voss and Carleton, 1993), but Handleyomys possesses other synapomorphies that cladistically affiliate it with that tribe, a relationship supported by molecular evaluation (Weksler, 2003). Nearest relatives remain uncertain (Voss et al., 2002); affiliated with certain Middle American Oryzomys according to nuclear DNA sequence data (Weksler, 2003).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1118, DOI: 10.5281/zenodo.7316535
Il concetto di fortuna (τύχη ed εὐτυχία) in Aristotele
Creators: name: Cardullo, R. Loredana
Publisher: name: Spazio Filosofico
Year: 2014

description: This essay analyzes the concept of “luck” in Aristotle on the basis of the two Greek words around which the Aristotelian doctrine in question gravitates, namely: tuche and eutuchia. The proposal here advanced is to translate tuche with “fate” and eutuchia with “good luck” or “prosperity” because the Italian “fortuna” (in English, luck or fortune), as tuche is normally translated, does not reflect the exact semantic value of the Greek notion. In fact, whereas tuche denotes a qualitatively neutral phenomenon, which is in itself neither good nor bad but is rather potentially declinable favorably (eutuchia) or unfavorably (atuchia), “luck” or “fortune” has a very positive meaning indicating prosperity, success, and, in short, a favorable fate. In Aristotle, the concepts of “luck” and “good luck” find their highest expression in the moral sphere. Here they are connected to the theme of happiness, but they denote the events and things that happen to people quite randomly in everyday life. An important and preliminary discussion of such concepts is in the second book of Physics, where Aristotle presents the four causes of reality, or the explanatory methods for everything that happens. Here, tuche and automaton (fate and case) are included under the etiological forms of Aristotelian causality as accidental (kata sumbebekos) causes. In the Ethics, Aristotle addresses the problem of “luck” and “good luck” and distances himself from the intellectual position of Plato, for whom wisdom and virtue are necessary and sufficient conditions of happiness and make human beings happy even when they are faced with the most adverse situations. On the opposite, for Aristotle, insofar as happiness is activity in accordance with virtue, it takes practice and commitment. The burden of fate within human existence, especially when it is negative, is able to disrupt the existence of even the happier human being. Yet, despite the recognition of the fragility of the acquired good and of human nature as they hang on the unpredictable vicissitudes of fate, in Aristotle’s ethics good character and virtues, once established, will allow the good and happy human being to face and withstand even the worst misfortunes with courage and intelligence.
description: Spazio Filosofico, 12. Fortuna
D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells
Creators: name: Hammon, Kathrin
name: Renner, Kathrin
name: Althammer, Michael
name: Voll, Florian
name: Babl, Nathalie
name: Decking, Sonja-Maria
name: Siska, Peter J.
name: Matos, Carina
name: Conejo, Zugey Elizabeth Cárdenas
name: Mendes, Karina
name: Einwag, Friederike
name: Siegmund, Heiko
name: Iberl, Sabine
name: Berger, Raffaela S.
name: Dettmer, Katja
name: Schoenmehl, Rebecca
name: Brochhausen, Christoph
name: Herr, Wolfgang
name: Oefner, Peter J.
name: Rehli, Michael
name: Thomas, Simone
name: Kreutz, Marina
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: 610 Medizin

description: D-2-hydroxyglutarate (D-2-HG) accumulates in primary acute myeloid leukemia (AML) patients with mutated isocitrate dehydrogenase (IDH) and other malignancies. D-2-HG suppresses antitumor T cell immunity but little is known about potential effects on non-malignant myeloid cells. Here we show that D-2-HG impairs human but not murine dendritic cell (DC) differentiation, resulting in a tolerogenic phenotype with low major histocompatibility (MHC) class II expression. In line, IDH-mutated AML blasts exhibited lower expression of HLA-DP and were less susceptible to lysis by HLA-DP-specific T cells. Interestingly, D-2-HG reprogrammed metabolism towards increased lactate production in DCs and AML besides its expected impact on DNA demethylation. Vitamin C accelerated DNA demethylation, but only the combination of vitamin C and glycolytic inhibition lowered lactate levels and supported MHC class II expression. Our results indicate an unexpected link between the immunosuppressive metabolites 2-HG and lactic acid and suggest a potentially novel therapeutic strategy with combinations of anti-glycolytic drugs and epigenetic modulators (hypomethylating agents) or other therapeutics for the treatment of AML.
Correspondence from Vienna: Chartae Latinae Antiquiores
Creators: name: Brückner, Albert
name: Fackelmann, Michael
name: Herrauer, Hermann
name: Lebenstein, Helene
name: Zelzer, Michaela
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 13
description: "Letters to Marichal from Austria (A. Brückner from Finkenberg; Österreichische Nationalbibliothek in Vienna), dated between 1975 and 1983, concerning Chartae Latinae Antiquiores (esp. vols. X -XII, Germany; XIII-XV France; references to the preparation of the miscellaneous vol. XLVI, and on the Austria volums); title by Marichal on the cover page of the folder: 'VIENNE. Correspondence' - 3 Letters (17-06-1975; 29-11-1976; 14-12-1976) by H. Herrauer informing Marichal on the publication of some Latin papyri of the Papyrussamlung of the Österreichische Nationalbibliothek.- Letter from A. Brückner (20-02-1976) on the availability showed by the Österreichische Nationalbibliothek for the study of papyri held in Viennanad their publication in the series Chartae Latinae Antiquiores. - 2 Letters from A. Brückner (16-05-1978, 26-07-1978) concerning the preparation of the Germany volumes (X-XII, 1978-79). - Letter from A. Brückner (28-08-1978) and letter from. H. Löbenstein (28-07-1978) concerning the work on the papyri of the collection of Vienna; Letter from A. Brückner (31-08-1978) informing Marichal on the work of classification and photographical reproduction of the papyri held in Vienna. - Letter from M. Fackelmann (18-09-1978) about the photographic reproduction of some Latin papyri of the Vienna collection. - Letter from A. Brückner (14-11-1978) joined to a letter from Michaela Zelzer (09-11-1978) on Zelzer's refuse of collaborating with Marichal and Brückner for the publication in the Chartae Latinae Antiquiores of Ambrosius' letters; additional remarks on the preparation of the miscellaneus vol. XLVI, with annotations by Marichal. - 2 Letters from A. Brückner (08-12-1978; 15-02-1979) on the prepaparation of the vols. XIII-XIV (France) and of the miscellaneous vol. XLVI. - Letter from Deutsches Historisches Institut of Paris (10-03-1983) informing Marichal on the publication of H. Herrauer et P.J. Sijpestejn, Drei Wiener Papyri zur antiken Buchfürung, Aegyptus 62 (1982), pp. 62-64. - Letter from A. Brückner on the preparation of the Austra volumes in the series Chartae Latinae Antiquiores"
description: Source: 4MAR_22_4_7-2
description: created: 1975-1983
Handleyomys fuscatus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Handleyomys
Handleyomys fuscatus

description: Handleyomys fuscatus (J. A. Allen 1912)
[Aepeomys] fuscatus J. A. Allen 1912, Bull. Am. Mus. Nat. Hist., 31: 89.
Type Locality: Colombia, Valle del Cauca Dept., San Antonio, near Cali, 7000 ft (2134 m).
Vernacular Names: Dusky-footed Handley's Mouse.
Distribution: Cordillera Occidental, 1700-2580 m, W Colombia.
Conservation: IUCN – Lower Risk (lc) as Aepomys fuscatus.
Discussion: Formerly ranked as a species of Thomasomys (Ellerman, 1941), subspecies of Aepeomys lugens (Cabrera, 1961), or usually a species of Aepeomys (Gardner and Patton, 1976; Musser and Carleton, 1993). Karyotype highly divergent among oryzomyines and thomasomyines reported by Gardner and Patton (1976). Specific status reinforced by Voss et al. (2002), who morphologically and morphometrically contrasted it to H. intectus.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1118, DOI: 10.5281/zenodo.7316535
Rethinking Franchise Contracts: The Impact of Transactional and Relational Governance Mechanisms on Franchisor Performance
Creators: name: ALSHAMRANI, AREEJ SAAD S
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 350604
subject: Marketing communications
classificationCode: 350699
subject: Marketing not elsewhere classified

description: This research explores how contract design influences growth in franchise systems. Franchising is a vital part of our economy, where a business grants others the right to operate under its brand. This study focuses on two key aspects within franchise contracts: 'contingency adaptability' which prepares for unforeseen changes, and 'franchisees' roles and responsibilities' which outline their duties. Additionally, it examines how relational aspects like information sharing and flexibility within contracts affect franchise growth. By analysing over 200,000 clauses from 332 franchisor contracts using advanced machine learning techniques, the research uncovers how different contract elements can either help or hinder the expansion of a franchise. This offers valuable insights for better contract design in franchising.
Peroxisome proliferator-activated receptorα/γ agonist pioglitazone for rescuing relapsed or refractory neoplasias by unlocking phenotypic plasticity
Creators: name: Harrer, Dennis Christoph
name: Lüke, Florian
name: Pukrop, Tobias
name: Ghibelli, Lina
name: Gerner, Christopher
name: Reichle, Albrecht
name: Heudobler, Daniel
Publisher: name: Universität Regensburg
Year: 2024
Subjects: subject: pioglitazone, interferon-a, dexamethasone, all-trans retinoic acid, tumor tissue editing, anakoinosis, transcriptional modulation, phenotypic plasticity
subject: 610 Medizin

description: A series of seven clinical trials on relapsed or refractory (r/r) metastatic neoplasias followed the question: Are networks of ligand-receptor cross-talks that support tumor-specific cancer hallmarks, druggable with tumor tissue editing approaches therapeutically exploiting tumor plasticity? Differential recombinations of pioglitazone, a dual peroxisome-proliferator activated receptorα/γ (PPARα/γ) agonist, with transcriptional modulators, i.e., all-trans retinoic acid, interferon-α, or dexamethasone plus metronomic low-dose chemotherapy (MCT) or epigenetic modeling with azacitidine plus/minus cyclooxygenase-2 inhibition initiated tumor-specific reprogramming of cancer hallmarks, as exemplified by inflammation control in r/r melanoma, renal clear cell carcinoma (RCCC), Hodgkin’s lymphoma (HL) and multisystem Langerhans cell histiocytosis (mLCH) or differentiation induction in non-promyelocytic acute myeloid leukemia (non-PML AML). Pioglitazone, integrated in differentially designed editing schedules, facilitated induction of tumor cell death as indicated by complete remission (CR) in r/r non-PML AML, continuous CR in r/r RCCC, mLCH, and in HL by addition of everolimus, or long-term disease control in melanoma by efficaciously controlling metastasis, post-therapy cancer repopulation and acquired cell-resistance and genetic/molecular-genetic tumor cell heterogeneity (M-CRAC). PPARα/γ agonists provided tumor-type agnostic biomodulatory efficacy across different histologic neoplasias. Tissue editing techniques disclose that wide-ranging functions of PPARα/γ agonists may be on-topic focused for differentially unlocking tumor phenotypes. Low-dose MCT facilitates targeted reprogramming of cancer hallmarks with transcriptional modulators, induction of tumor cell death, M-CRAC control and editing of non-oncogene addiction. Thus, pioglitazone, integrated in tumor tissue editing protocols, is an important biomodulatory drug for addressing urgent therapeutic problems, such as M-CRAC in relapsed or refractory tumor disease.
Tiefenpsychologie und Moraltheologie - ein unüberwindbarer Konflikt?
Creators: name: Endres, Joseph
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24