cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Differences in brain regions of three mice strains identified by label-free micro-Raman
Creators: name: Segura-Uribe, Julia Jeanett
name: Farfán-García, Eunice Dalet
name: Guerra-Araiza, Christian
name: Ciprés-Flores, Fabiola Jimena
name: Torre, Paola García-Dela
name: Soriano-Ursúa, Marvin Antonio
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified

description: The analysis of different central nervous system regions is interesting and necessary as each one is involved in specific physiological processes and pathologies. On that matter, differences in the chemical composition between the same brain regions in different mice strains have been reported. In this sense, the development of a simple method for the identification of these regions depending on their chemical composition becomes relevant. Raman microspectroscopy, a non-destructive analytical chemical approach for biological samples, is a widely used method for qualitative, quantitative, and structural analysis in biochemical research. Ten brain structures in three different mice strains (Triple transgenic for Alzheimer Disease, 3xTgAD; Cluster 57 black 6, C57BL/6; and the Swiss strain, CD1) were analyzed, and variations among samples from several brain regions were found. Particularly, the pattern of signals from the hippocampus, the prefrontal and temporal cortices, the basal forebrain, the striatum, the cerebellum, and the hypothalamus was discernable. Interestingly, notable signals regarding non-peptide small neurotransmitters were observed, including those related to acetylcholine. These bands were present in the Raman spectra of the basal forebrain and prefrontal cortex in the three mice strains, consistent with the relative abundance of this neurotransmitter in those regions. However, signals with lower intensities appeared in the basal forebrain of C57BL/6 in comparison with the same tissue of the other two strains. In addition, the Raman intensity of bands assigned to catecholamines in the striatum was lower in the 3xTgAD than those from both CD1 and C57BL/6 mice strains. This approach, as well as the reported differences, has potential application for designing analysis on specific murine models of brain diseases.
Fe II emission lines in the UV spectrum of Sirius-A and Vega
Creators: name: van Noort, M.
name: Lanz, T.
name: Lamers, H. J. G. L. M.
name: Kurucz, R. L.
name: Ferlet, R.
name: Hebrard, G.
name: Vidal-Madjar, A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present high-quality HST/GHRS spectra in the Hydrogen L alpha spectral region of Vega and Sirius-A. Thanks to the signal-to-noise ratio achieved in these observations and to the similarity of the two spectra, we found clear evidence of emission features in the low flux region, 1190-1222 A. These emission lines can be attributed unambiguously to Fe II and Cr II transitions. In this spectral range, silicon lines are observed in absorption. We built a series of non-LTE model atmospheres with different, prescribed temperature stratification in the upper atmosphere and treating Fe II with various degrees of sophistication in non-LTE. Emission lines are produced by the combined effect of the Schuster mechanism and radiative interlocking, and can be explained without the presence of a chromosphere. Silicon absorption lines and the L alpha profile set constraints on the presence of a chromosphere, excluding a strong temperature rise in layers deeper than tau_R ~ 10^{-4}.
description: 14 pages including 11 figures; accepted for publication in Astronomy & Astrophysics
An ultra-compact low temperature scanning probe microscope for magnetic fields above 30 T
Creators: name: Rossi, L.
name: Gerritsen, J. W.
name: Nelemans, L.
name: Khajetoorians, A. A.
name: Bryant, B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We present the design of a highly compact High Field Scanning Probe Microscope (HF-SPM) for operation at cryogenic temperatures in an extremely high magnetic field, provided by a water-cooled Bitter magnet able to reach 38 T. The HF-SPM is 14 mm in diameter: an Attocube nano-positioner controls the coarse approach of a piezo resistive AFM cantilever to a scanned sample. The Bitter magnet constitutes an extreme environment for SPM due to the high level of vibrational noise; the Bitter magnet noise at frequencies up to 300 kHz is characterized and noise mitigation methods are described. The performance of the HF-SPM is demonstrated by topographic imaging and noise measurements at up to 30 T. Additionally, the use of the SPM as a three-dimensional dilatometer for magnetostriction measurements is demonstrated via measurements on a magnetically frustrated spinel sample.
description: 6 pages, 5 figures
New Developments in Lattice QCD: Calculation of Flavor Singlet Nucleon Matrix Elements and Hadron Scattering Lengths
Creators: name: Okawa, Masanori
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Recent developments in lattice QCD calculation of flavor singlet nucleon matrix elements are reviewed. Substantial sea quark contributions are found in the $π$-$N\ σ$ term and the quark spin content of the nucleon such that the total magnitude including valence contributions is in reasonable agreement with experiments. Some problems with flavor non-singlet nucleon matrix elements are pointed out. Recent work on lattice QCD calculation of hadron scattering length is also discussed.
description: Plenary talk given at the International Symposium on Lattice Field Theory {\it LATTICE 95}, Melbourne, Australia, 11-15 July, 1995, 12pages, 15 Postscript figures
Functional annotation of dinoflagellate protein sequences and structural prediction by deep learning approach
Creators: name: Rousseau, Jérémy
name: Bittner, Lucie
name: Carpentier, Mathilde
Publisher: name: Zenodo
Year: 2023

description: Dinoflagellates are one of the most abundant and functionally diverse groups of microbial eukaryotes. They exhibit remarkable molecular features including gigabase-sized nuclear genomes, permanently condensed chromosomes, and a 10-fold lower ratio of protein to DNA than other eukaryotic species. Genomic and transcriptomic studies from the last decade based on cultivated dinoflagellates confirmed their remarkable sequence divergence and complexity. They revealed millions of « dark » proteins, i.e., proteins that have no significant similarity to any known sequences, and that are functionally unknown.

In this context, we developed a new methodology allowing the functional and structural analysis of protein sequences from dinoflagellate transcriptomes and genomes. We start with a classical functional annotation with InterProScan. We then build sequence similarity networks based on Diamond pairwise alignments in order to create sequence clusters that are connected components. The optimal parameters of e-value, sequence alignment overlap and sequences identity were determined based on maximising the number of large components while having a high functional homogeneity score depending on Pfam annotations. Our goal is to delineate components which share sequences with similar molecular function. Moreover, as structure is more conserved than sequence we predict the 3rd structure of the sequences using the last deep learning based programs, in order to also maximise structural homogeneity structure within each componentand to further functionally annotate sequences.

Our pipeline targets the functional exploration of a genomically hyperdiverse lineage of non model eukaryotes. It aims at providing the baselines for future investigations on the metabolism, the physiology, the ecology as well as the evolution of these successful micro-organisms. Moreover, we also hope to find new protein folds that are absent from the databases.
Is quantum steering spooky?
Creators: name: Pusey, Matthew Fairbairn
Publisher: name: Imperial College London
Year: 2013

description: In quantum mechanics, if one party performs a measurement on one system, different outcomes can lead to different states for another system. This phenomenon is known as quantum steering. The thesis begins with some general results about steering: a classification of which states permit the most powerful type of steering, and the implications of this for quantum correlations. The first main topic is steering in two-qubit systems. It turns out that steering provides an excellent way to visualize two-qubit states, leading to a novel criteria for entanglement and a better understanding of separable states. Oddly, the structure of steering can be more subtle in separable states than it can be in entangled ones. Returning to general quantum systems, I then turn to the EPR paradox, and its generalisation using Local Hidden State models. I show that the lack of such models can be used to quantify the amount of entanglement shared by two parties, even when one of them does not trust their measuring devices. Finally, the desire to understand steering without invoking "spooky action-at- a-distance" leads to the idea that quantum states are states of knowledge. I explore some de Finetti theorems that help to make sense of this idea, but then show a significant roadblock the most natural formalisation of it. The main results in chapters 3 and 4 appear in [JPJR13] and [Pus13] respectively. The result in chapter 6 was improved in collaboration with my supervisors and published in [PBR12].
Constraint On The Cosmological Constant From Gravitational Lenses In An Evolutionary Model Of Galaxies
Creators: name: Jain, Deepak
name: Panchapakesan, N.
name: Mahajan, S.
name: Bhatia, V. B.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the effect of the cosmological constant on the statistical properties of gravitational lenses in flat cosmologies (Omega_{0}+lambda_{0} = 1). It is shown that some of the lens observables are strongly affected by the cosmological constant, especially in a low--density universe, and its existence might be inferred by a statistical study of the lenses. In particular, the optical depth of the lens distribution may be used best for this purpose without depending much on the lens model. We calculate the optical depth (probabilty of a beam encountering with a lens event) for a source in a new picture of galaxy evolution based on number evolution in addition to pure luminosity evolution. It seems that present day galaxies result from the merging of a large number of building blocks. We have tried to put limit on the cosmological constant in this new picture of galaxy evolution. This evolutionary model of galaxies permits larger value of cosmological constant.
description: Latex file with two figures, 24 pages
Light meson decay constants beyond the quenched approximation
Creators: name: de Divitiis, G. M.
name: Frezzotti, R.
name: Guagnelli, M.
name: Masetti, M.
name: Petronzio, R.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We calculate the effects of including dynamical fermion loops in the lattice QCD estimates of meson decay constants, by extrapolating the results from negative flavour numbers after a suitable matching of the pion and rho mass. For moderately light quarks, the values of the decay constants not corrected for the renormalization constants increase with respect to their quenched values.
description: 9 pages, uuencoded PS file, 2 figures included
Additional file 1 of Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project
Creators: name: Moessnang, Carolin
name: Baumeister, Sarah
name: Tillmann, Julian
name: Goyard, David
name: Charman, Tony
name: Ambrosino, Sara
name: Baron-Cohen, Simon
name: Beckmann, Christian
name: Bölte, Sven
name: Bours, Carsten
name: Crawley, Daisy
name: Dell’Acqua, Flavio
name: Durston, Sarah
name: Ecker, Christine
name: Frouin, Vincent
name: Hayward, Hannah
name: Holt, Rosemary
name: Johnson, Mark
name: Jones, Emily
name: Lai, Meng-Chuan
name: Lombardo, Michael
name: Mason, Luke
name: Oldenhinkel, Marianne
name: Persico, Antonio
name: Cáceres, Antonia
name: Spooren, Will
name: Loth, Eva
name: Murphy, Declan
name: Buitelaar, Jan
name: Banaschewski, Tobias
name: Brandeis, Daniel
name: Tost, Heike
name: Meyer-Lindenberg, Andreas
Publisher: name: figshare
Year: 2020
Subjects: subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Additional file 1. Supplementary Material.
D3.1 - GreenSCENT platform design and integration
Creators: name: Pollini, Alessandro
name: Giacobone, Gian Andrea
Publisher: name: Zenodo
Year: 2024

description: This document presents the D3.1 - GreenSCENT platform design and integration by introducing the theoreticalframework of the Sustainable Interaction Design, its historical roots, its current methods and researchperspectives and, in particular, the designing for low resource scenarios approach developed in theGreenSCENT project. This deliverable describes the interaction and interface design activity developed withinTask 3.1 - Design concept and interaction design of the GreenScent Identity, including the description of theiterative, participatory and incremental design methodology implemented in the task and all the design cycles,regarded as internal to the design team as well as with the involvement of end users.

At the core of the deliverable there is the EXPLOR design concept that integrates the many perspectives ofGreenSCENT into an educational service and interaction design activity. EXPLOR suggests a unique journeythat integrates multiple users' perspectives, including the teachers, the students, the researchers, into asustainability education GreenSCENT scenario. The EXPLOR concept allows the reader to also put in relationthe different technologies of the GreenSCENT ecosystem, the way of interacting with these systems and thepossible adoption in sustainability education, meaning the GreenVERSE, the GreenSCENT mobile app, theGreenSCENT AR Mobile App and the GreenSCENT CleanAir App.
QCD for Coarse Lattices
Creators: name: Lepage, Peter
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: This is the Lattice '95 review of recent progress towards accurate QCD simulations using very coarse lattices. This development could have revolutionary implications for low energy (nonperturbative) QCD.
description: 14 pages
Mathematical modelling and systems analysis of intracellular signalling networks and the budding yeast cell cycle
Creators: name: Seaton, Daniel
Publisher: name: Imperial College London
Year: 2012

description: Cellular signalling networks are responsible for coordinating a cell’s response to internal and external perturbations. In order to do this, these networks make use of a wide variety of molecular mechanisms, including allostery, gene regulation, and post-translational modifications. Mathematical modelling and systems approaches have been useful in understanding the signal processing capabilities and potential behaviours of such networks. In this thesis, a series of mathematical modelling and systems investigations are presented into the potential regulation of a variety of cellular systems. These systems range from ubiquitously seen mechanisms and motifs, common to a wide variety of signalling pathways across many organisms, to the study of a particular process in a particular cell type - the cell cycle in Saccharomyces cerevisiae. The first part of the thesis involves the analysis of ubiquitous signalling mechanisms and behaviours. The potential behaviours of these systems are examined, with particular attention paid to properties such as adaptive and switch-like signalling. This series of investigations is followed by a study of the dynamic regulation of cell cycle oscillators by external signalling pathways. A methodology is developed for the study of mathematical models of the cell cycle, based on linear sensitivity analysis, and this methodology is then applied to a range of models of the cell cycle in Saccharomyces cerevisiae. This allows the description of some interesting generic behaviours, such as nonmonotonic approach of cell cycle characteristics to their eventual values, as well as allowing identification of potential principles of dynamic regulation of the cell cycle.
Quantitative analysis of the effect of foam morphology on the quasi-static and cyclic-dynamic tensile properties
Creators: name: Güzel, Kübra
name: Zarges, Jan-Christoph
name: Heim, Hans-Peter
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: Foam injection molding
subject: Fatigue testing
subject: Cyclic dynamic loading
subject: Digital image correlation
subject: Polycarbonate
subject: 600
subject: Polycarbonate
subject: Spritzgießen
subject: Materialermüdung
subject: Schaumkunststoff

description: Gefördert im Rahmen des Projekts DEAL
A Quest for Self Determination: Kashmir and Incomplete Decolonisation
Creators: name: Maqbool, Sahiba
Publisher: name: La Trobe
Year: 2025
Subjects: classificationCode: 480303
subject: Conflict of laws (incl. private international law)
classificationCode: 430301
subject: Asian history
classificationCode: 430304
subject: British history
classificationCode: 430313
subject: History of empires, imperialism and colonialism
classificationCode: 430312
subject: Histories of race

description: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the La Trobe Law School, La Trobe University, Victoria, Australia.
A Three – tier bio-implantable sensor monitoring and communications platform
Creators: name: Sanni, Ayodele Adebayo
Publisher: name: Imperial College London
Year: 2012

description: One major hindrance to the advent of novel bio-implantable sensor technologies is the need for a reliable power source and data communications platform capable of continuously, remotely, and wirelessly monitoring deeply implantable biomedical devices. This research proposes the feasibility and potential of combining well established, ‘human-friendly' inductive and ultrasonic technologies to produce a proof-of-concept, generic, multi-tier power transfer and data communication platform suitable for low-power, periodically-activated implantable analogue bio-sensors. In the inductive sub-system presented, 5 W of power is transferred across a 10 mm gap between a single pair of 39 mm (primary) and 33 mm (secondary) circular printed spiral coils (PSCs). These are printed using an 8000 dpi resolution photoplotter and fabricated on PCB by wet-etching, to the maximum permissible density. Our ultrasonic sub-system, consisting of a single pair of Pz21 (transmitter) and Pz26 (receiver) piezoelectric PZT ceramic discs driven by low-frequency, radial/planar excitation (-31 mode), without acoustic matching layers, is also reported here for the first time. The discs are characterised by propagation tank test and directly driven by the inductively coupled power to deliver 29 μW to a receiver (implant) employing a low voltage start-up IC positioned 70 mm deep within a homogeneous liquid phantom. No batteries are used. The deep implant is thus intermittently powered every 800 ms to charge a capacitor which enables its microcontroller, operating with a 500 kHz clock, to transmit a single nibble (4 bits) of digitized sensed data over a period of ~18 ms from deep within the phantom, to the outside world. A power transfer efficiency of 83% using our prototype CMOS logic-gate IC driver is reported for the inductively coupled part of the system. Overall prototype system power consumption is 2.3 W with a total power transfer efficiency of 1% achieved across the tiers.
Deep radio observations of 3C324 and 3C368: evidence for jet-cloud interactions
Creators: name: Best, P. N.
name: Carilli, C.
name: Garrington, S. T.
name: Longair, M. S.
name: R"ottgering, H. J. A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: High resolution, deep radio images are presented for two distant radio galaxies, 3C324 (z=1.206) and 3C368 (z=1.132), which are both prime examples of the radio-optical alignment effect seen in powerful radio galaxies with redshifts z > 0.6. Radio observations were made using the Very Large Array in A-array configuration at 5 and 8 GHz, and using the MERLIN array at 1.4 and 1.65 GHz. Radio spectral index, radio polarisation, and rotation measure maps are presented for both sources. Radio core candidates are detected in each source, and by aligning these with the centroid of the infrared emission the radio and the optical/infrared images can be related astrometrically with 0.1 arcsec accuracy. In each source the radio core is located at a minimum of the optical emission, probably associated with a central dust lane. Both sources also exhibit radio jets which lie along the directions of the bright strings of optical knots seen in high resolution Hubble Space Telescope images. The northern arm of 3C368 shows a close correlation between the radio and optical emission, whilst along the jet direction of 3C324 the bright radio and optical knots are co-linear but not co-spatial. These indicate that interactions between the radio jet and its environment play a key role in producing the excess ultraviolet emission of these sources, but that the detailed mechanisms vary from source to source. 3C368 is strongly depolarised and has an average rest-frame rotation measure of a few hundred rad/m^2, reaching about 1000 rad/m^2 close to the most depolarised regions. 3C324 has weaker depolarisation, and an average rest-frame rotation measure of between 100 and 200 rad/m^2. Both sources show large gradients in their rotation measure structures, with variations of up to 1000 rad/m^2 over distances of about 10 kpc.
description: 15 pages including 4 figures. LaTeX. Accepted for publication in MNRAS
Examining the Mechanisms of How Surface Modification Alters the Flow of Fine Powders
Creators: name: TAN, GEOFFREY
Publisher: name: Monash University
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: This research aimed to improve our understanding of the mechanisms of how the application of a pharmaceutical lubricant coating onto the small particles of fine powders changes how the powder flows. Coated powders flowed better because the coating significantly reduced the strength of the naturally strong attractive forces between the particles. However, the thickness and extent of the coating was also influential on the flow behaviours of the powders. Powders with a partial coating only showed better flow under specific conditions, while powders with thick coatings flowed more poorly than powders with a thin coating.
Monte Carlo Simulations of Conformal Theory Predictions for the 3-state Potts and Ising Models
Creators: name: Barkema, Gerard
name: McCabe, John
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The critical properties of the 2D Ising and 3-state Potts models are investigated using Monte Carlo simulations. Special interest is given to measurement of 3-point correlation functions and associated universal objects, i.e. structure constants. The results agree well with predictions coming from conformal field theory confirming, for these examples, the correctness of the Coulomb gas formalism and the bootstrap method.
description: 11 pages, 6 Postscript figures, uses Revtex
title: CO₂ als Kohlenstoffquelle für Kunststoffprodukte
title: Vergleichende Analyse von CO₂- und fossilbasierten Wertschöpfungsketten. Emissionen und Kosten
Creators: name: Kaiser, Simon
name: Digulla, Finn-Erik
name: Bringezu, Stefan
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: 330
subject: 500
subject: 660
subject: Wertschöpfungskette
subject: Kunststoffverarbeitung
subject: Kohlenstoff
subject: Emission
subject: Kosten

description: Bundesministerium für Bildung und Forschung Referat 726: Ressourcen, Kreislaufwirtschaft, Geoforschung Dr. Vera Grimm Fördermaßnahme: CO2WIN – CO2 als nachhaltige Kohlenstoffquelle – Wege zur industriellen Nutzung
Accurate Determination of the Solar Photospheric Radius
Creators: name: Brown, T. M.
name: Christensen-Dalsgaard, J.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Solar Diameter Monitor measured the duration of solar meridian transits during the 6 years 1981 to 1987, spanning the declining half of solar cycle 21. We have combined these photoelectric measurements with models of the solar limb-darkening function, deriving a mean value for the solar near-equatorial radius of 695.508 +- .026 Mm. Annual averages of the radius are identical within the measurement error of +- .037 Mm.
description: 6 pages, 2 figures Submitted to Astrophys. J. Lett., March 9 1998 Uses AASTeX Macro package aas2pp4
Excessive shift of the CMB acoustic peaks of the Cold Spot area
Creators: name: Chiang, Lung-Yih
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Measurement of the acoustic peaks of the cosmic microwave background (CMB) temperature anisotropies has been instrumental in deciding the geometry and content of the universe. Acoustic peak positions vary in different parts of the sky due to statistical fluctuation. We present the statistics of the peak positions of small patches from ESA Planck data. We found that the peak positions have significantly high variance compared to the 100 CMB simulations with best-fit LambdaCDM model with lensing and Doppler boosting effects included. Examining individual patches, we found the one containing the mysterious "Cold Spot", an area near the Eridanus constellation where the temperature is significantly lower than Gaussian theory predicts, displays large synchronous shift of peak positions towards smaller multipole numbers with significance lower than 1.11x 10^{-4}. The combination of large synchronous shifts in acoustic peaks and lower than usual temperature at the Cold Spot area results in a 4.73-sigma detection (significance p~ 1.11x 10^{-6}) against the LambdaCDM model. And it was already reported in Finelli et al. (2016) that in the WISE-2MASS galaxy catalog at z<0.3 the Cold Spot region is surrounded by surprisingly large underdense regions around 15 degs in radius, which are found to be in the same square patch. Thus we propose there is some extra localized unknown energy to stretch out the space in the transverse direction around the Cold Spot area to simultaneously account for the Cold Spot, excessive shift of the acoustic peaks, and the large underdense regions.
description: 8 pages, 7 figures, correction for typos
The Shape of the Renormalized Trajectory in the Two-dimensional O(N) Non-linear Sigma Model
Creators: name: Bock, Wolfgang
name: Kuti, Julius
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The renormalized trajectory in the multi-dimensional coupling parameter space of the two-dimensional O(3) non-linear sigma model is determined numerically under \linebreak $δ$-function block spin transformations using two different Monte Carlo renormalization group techniques. The renormalized trajectory is compared with the straight line of the fixed point trajectory (fixed point action) which leaves the asymptotically free ultraviolet fixed point of the critical surface in the orthogonal direction. Our results show that the renormalized trajectory breaks away from the fixed point trajectory in a range of the correlation length around $ξ\approx 3$-$7$, flowing into the high temperature fixed point at $ξ=0$. The analytic large $N$ calculation of the renormalized trajectory is also presented in the coupling parameter space of the most general bilinear Hamiltonians. The renormalized trajectory in the large $N$ approximation exhibits a similar shape as in the $N=3$ case, with the sharp break occurring at a smaller correlation length of $ξ\approx 2$-$3$.
description: 9 pages, compressed and uuencoded postscript file (compressed file is 434 Kbytes.) A reference is added with a minor modification of the text and fig.3b
An operational model for liquefied natural gas spot and arbitrage sales
Creators: name: Nikhalat-Jahromi, Hamed
Publisher: name: Imperial College London
Year: 2012

description: As more buyers become interested in the spot purchase of liquefied natural gas (LNG), the share of spot trade in LNG business increases. This means that the cash flowing into the upstream of LNG projects is a combination of that generated by deliveries to long-term contract (LTC) customers and uncommitted product and arbitrage spot sales. LTC cash flows are more predictable while uncommitted product and arbitrage cash flows, affected by the dynamics of supply and demand, are more volatile and therefore less predictable. In this research, we formulate an inventory routing problem (IRP) which maximizes the profit of an LNG producer with respect to uncommitted product and arbitrage spot sales, and also LTC deliveries at an operational level. Using the model, the importance of arbitrage, interest rates and compounding frequency in profit maximization, and also the significance of interest rates and fluctuation in spot prices in decision-making for spot sales of uncommitted product are studied. It is proven that writing traditional LTCs with relaxed destination clauses which assist in arbitrage is beneficial to the LNG producer. However, in contrast to what was predicted neither the interest rate nor the compounding frequency has any importance in profit maximization when no change of selling strategy is observed. Apart from these, it is shown that there is a trade-off between the expectation of higher spot prices and the inventory and shipping costs in decision-making for spot sales of uncommitted product in the LNG industry. Finally, it is observed that the interest rate can affect the set of decisions on spot sales of uncommitted product, although the importance of such changes in profit remains to be further explored.
$B_c$ and $Υ$ Spectra from Lattice NRQCD - Results at $β$ = 5.7
Creators: name: Davies, C. T. H.
name: Lidsey, A. J.
name: Hornbostel, K.
name: Lepage, G. P.
name: Shigemitsu, J.
name: Sloan, J.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We update our results for the heavy-heavy spectrum at $β$ = 5.7, using NRQCD. This includes a scaling comparison with the $Υ$ spectrum at $β$ = 6.0 and first lattice predictions for the $B_c$ spectrum.
description: 4 pages of uuencoded latex. Uses espcrc2.sty. Contribution to LAT95
An effective, simple and low-cost pretreatment for culture clarification in tetanus toxoid production
Creators: name: Avila, Lucía
name: Cascone, Osvaldo
name: Biscoglio, Mirtha
name: Fingermann, Matías
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Biology

description: Chemically inactivated tetanus toxin (tetanus toxoid, TT), purified from cultures of a virulent Clostridium tetani strain, is the active pharmaceutical ingredient of anti-tetanus vaccines. Culture clarification for TT production and is usually performed by filtration-based techniques. Final clarification of the culture supernatant is achieved by passage through 0.2 µm pore size filtering membranes. Large particles removal (primary clarification) before final filtration (secondary clarification) reduces costs of the overall clarification process. With this aim, chitosan-induced particle aggregation was assessed as an alternative for primary clarification. Three chitosan variants were tested with similar results. Optimal clarification of culture supernatant was achieved by the addition of 8 mg chitosan per l of culture. Extrapolation analysis of filter sizing results indicate that 100 l of chitosan-treated supernatant can be finally filtered with a 0.6 m2 normal filtration cartridge of 0.45 + 0.2 µm pore size. The clarified material is compatible with current standard downstream processing techniques for TT purification. Thus, chitosan-induced particle aggregation is a suitable operation for primary clarification.
Oral history interview with Zachary Scott, 1959
Publisher: name: Columbia University
Year: 2020
Subjects: Actors
Theater
Motion pictures
Motion picture actors and actresses

description: Early life in Texas; travels in England; English repertory company during 1930s; early career on Broadway and in Hollywood: "The Southerner," 1944, and "Mildred Pierce," 1946; production of "Requiem for a Nun," 1959; comparison of English and American theater; image as an actor; impressions of William Faulkner and Jean Renoir. Audio is comprised of narrator's excerpts from the Westinghouse Broadcasting Company's radio program series "Memoirs of the Movies"
Towards synthetic mutagenesis of aromatic residues in peptides for disrupting protein-protein interactions
Creators: name: Mo, Bingli
Publisher: name: Imperial College London
Year: 2011

description: The research described in this thesis covers two fields of investigation: 1) Development of Peptidic Inhibitors of the IgE-FcєRI Protein-Protein Interaction in Allergy. When Immunoglobulin E (IgE) binds to its high affinity receptor protein FcєRI on the surface of mast cells or blood basophiles, it can cause an immediate allergic reaction by triggering the release of toxic inflammatory agents. Inhibition of the protein-protein interactions (PPIs) between IgE and FcєRI is known to prevent the release of inflammatory agents; thereby effectively targeting allergic disorders. In this thesis, the development of a retro-αFcєRI C-region mimic peptidic inhibitor (named BM1149-Am; IC50 = 77±11 μM av.) from the study of literature peptidic inhibitors is described. Structure-activity relationship (SAR) studies of BM1149-Am using alanine-scan and truncation techniques identified the key structural epitope along the sequence to be Tyr-Tyr-Ile-Val. One of the alanine-scan analogues, [Y8A] BM1149-Am showed a 10-fold improved IC50 value in ELISA assay compared to that of BM1149-Am. 2) Towards Aryl Germane-Based Synthetic Mutagenesis of Peptides Synthetic mutagenesis of aromatic amino acids (AAAs), in particular phenylalanine (Phe) and tyrosine (Tyr), to give biaryl derivatives are of great interest. Such biaryl units are important structural elements in protein-protein interactions (PPI). Biaryls are generally prepared by cross-coupling between aryl metals and aryl halides. In this thesis, fluorous-tagged silyl germanes were studied as the precursor towards a new generation of aryl metals. Silyl germanes were successfully synthesised from commercially available germanium(IV) chloride in eight steps. Literature conditions reported for coupling of both metal hydride and bimetallo group 14 compounds with aryl halides as well as modified variants were screened. Conditions where a CuI-6- methyl-2-(hydroxymethyl)pyridine complex was used as an additive to a Pd(OAc)2- dppf catalyst system was found to be the best, although even these conditions had limited substrate scope.
The formation and assembly history of the Milky Way revealed by its globular cluster population
Creators: name: Kruijssen, J. M. Diederik
name: Pfeffer, Joel L.
name: Reina-Campos, Marta
name: Crain, Robert A.
name: Bastian, Nate
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use the age-metallicity distribution of 96 Galactic globular clusters (GCs) to infer the formation and assembly history of the Milky Way (MW), culminating in the reconstruction of its merger tree. Based on a quantitative comparison of the Galactic GC population to the 25 cosmological zoom-in simulations of MW-mass galaxies in the E-MOSAICS project, which self-consistently model the formation and evolution of GC populations in a cosmological context, we find that the MW assembled quickly for its mass, reaching $\{25,50\}\%$ of its present-day halo mass already at $z=\{3,1.5\}$ and half of its present-day stellar mass at $z=1.2$. We reconstruct the MW's merger tree from its GC age-metallicity distribution, inferring the number of mergers as a function of mass ratio and redshift. These statistics place the MW's assembly $\textit{rate}$ among the 72th-94th percentile of the E-MOSAICS galaxies, whereas its $\textit{integrated}$ properties (e.g. number of mergers, halo concentration) match the median of the simulations. We conclude that the MW has experienced no major mergers (mass ratios $>$1:4) since $z\sim4$, sharpening previous limits of $z\sim2$. We identify three massive satellite progenitors and constrain their mass growth and enrichment histories. Two are proposed to correspond to Sagittarius (few $10^8~{\rm M}_\odot$) and the GCs formerly associated with Canis Major ($\sim10^9~{\rm M}_\odot$). The third satellite has no known associated relic and was likely accreted between $z=0.6$-$1.3$. We name this enigmatic galaxy $\textit{Kraken}$ and propose that it is the most massive satellite ($M_*\sim2\times10^9~{\rm M}_\odot$) ever accreted by the MW. We predict that $\sim40\%$ of the Galactic GCs formed ex-situ (in galaxies with masses $M_*=2\times10^7$-$2\times10^9~{\rm M}_\odot$), with $6\pm1$ being former nuclear clusters.
description: 24 pages (including appendices), 6 figures, 5 tables; accepted by MNRAS (June 12, 2018), originally submitted on March 25, 2018; Figures 4 and 6 show the main results of the paper. Updated with published version, clarifying the intended historical use of "Canis Major" as referring to a group of GCs rather than a galaxy
Investigating the neuroprotective effects of histone deacetylase inhibitors in Parkinson's Disease
Creators: name: Harrison, Ian
Publisher: name: Imperial College London
Year: 2014

description: Parkinson’s disease (PD) is the most common movement disorder and the second most common neurodegenerative disease affecting around 4 million people worldwide. Movement symptoms in PD are primarily due to degeneration of dopaminergic nigrostriatal neurons. These symptoms can be partially controlled by dopamine replacement therapies, however long term use of these drugs lead to debilitating side-effects and more importantly do not protect degenerating dopaminergic neurons from death. Hence novel neuroprotective strategies are sought. Recent evidence implicates αSynuclein accumulation, the hallmark of degenerating neurons in PD, with perturbed epigenetic acetylation of histone proteins around which DNA is coiled. A misbalance between the activities of the two enzyme classes responsible for control of histone acetylation, histone acetyltransferases and histone deacetylases (HDACs), have been linked to cell death in animal models of neurodegeneration. It is therefore hypothesised that if this pathogenic imbalance can be rectified with the use of HDAC inhibitors (HDACIs) then neurodegeneration observed in PD can be avoided. Here, the first evidence of altered histone acetylation and perturbed HDAC isoform expression in degenerating regions of the human Parkinsonian brain are demonstrated. Cell culture studies using dopaminergic neuronal and microglial cell lines demonstrate that dependent on the HDAC class(s) or isoform(s) inhibited, HDACIs are capable of inducing neuroprotection and reduction of microglial activation in vitro. Study of two broad-spectrum HDACIs in vivo, in the lactacystin rat model of PD demonstrate that, also dependent on isoform inhibition, HDACIs cause dose-dependent histone acetylation and upregulated expression of neurotrophic and neuroprotective factors, resulting in dopaminergic nigrostriatal neuroprotection and reduction of morphological changes and motor behavioural deficits detected through magnetic resonance imaging and behavioural testing respectively. Taken together the data herein provide compelling evidence to support the concept that dependent on isoform specificity, HDACIs represent a novel class of neuroprotective therapeutics for the treatment of PD.
The poor cluster of galaxies S639
Creators: name: Jorgensen, Inger
name: Jonch-Sorensen, Helge
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have studied the poor southern cluster of galaxies S639. Based on new Stromgren photometry of stars in the direction of the cluster we confirm that the galactic extinction affecting the cluster is large. We find the extinction in Johnson B to be A_B = 0.75+-0.03. We have obtained new photometry in Gunn r for E and S0 galaxies in the cluster. If the Fundamental Plane is used for determination of the relative distance and the peculiar velocity of the cluster we find a distance, in velocity units, of 5706+-350 km/s, and a substantial peculiar velocity, 839+-350 km/s. However, the colors and the absorption line indices of the E and S0 galaxies indicate that the stellar populations in these galaxies are different from those in similar galaxies in the two rich clusters Coma and HydraI. This difference may severely affect the distance determination and the derived peculiar velocity. The data are consistent with a non-significant peculiar velocity for S639 and the galaxies in the cluster being on average 0.2 dex younger than similar galaxies in Coma and HydraI. The results for S639 caution that some large peculiar velocities may be spurious and caused by unusual stellar populations.
description: 9 pages, 5 figures and 3 tables included, LaTeX MN style. Accepted for publication in MNRAS
Excited states in the full QCD hadron spectrum on a $16^3 \times 40$ lattice
Creators: name: Chen, Dong
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We report the hadron mass spectrum obtained on a $16^3 \times 40$ lattice at $β= 5.7$ using two flavors of staggered fermions with $m a = 0.01$. We calculate the masses of excited states that have the same quantum numbers as the $π$, $ρ$ and $N$. They are obtained by a combined analysis of the hadron correlators from sources of size $16^3$ and $8^3$. We also report on the hadron spectrum for a wide range of valence quark masses.
description: Contribution to Lattice 95. 4 pages. Compressed, uuencoded postscript file. Send questions to dch@cuphyf.columbia.edu
Analysis of saddle-point configurations in 3-dimensional SU(2) gauge theory
Creators: name: Jung, Chulwoo
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We discuss the properties of a class of saddle point solutions in SU(2) in three dimensions (SU$(2)_3$), exhibiting localized peaks in the action. These configurations are generated by deterministic cooling and extremizing algorithms from analytic configurations. They share some characteristics with cooled and extremized Monte Carlo generated lattices. We have investigated physical behavior such as the string tension by averaging over this class of saddle point configurations. We have also measured the eigenvalues for harmonic fluctuations around these configurations.
description: Contribution to Lattice 95. 4 pages. Compressed, uuencoded postscript file. Send questions to chulwoo@cuphyb.phys.columbia.edu
Ground-State Cooling in Cavity Optomechanics with Unresolved Sidebands
Creators: name: Al-Awfi, Saud
name: Al-Hmoud, Mohannad
name: Bougouffa, Smail
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider a simple cavity optomechanics and study the ground-state cooling of mechanical resonator in the quantum regime. Using the effective master equations in the linear regime, the equations of motion can be obtained for the second order moments. The steady state solutions are derived in the case where the antiresonant terms are ignored. The final mean value of phonon number is compared to the case where the antiresonant terms are included. We find that the ground-state cooling in the last case is improved. Indeed, the inclusion of the antiresonant terms makes the system able to generate a squeezed field, which is required for enhancing cooling. The variances of the resultant field are presented. Analytic calculations are presented in some appropriate regimes. Then our analytic predictions are confirmed with numerical calculations.
description: 7 pages, 7 figures
Examining the association between psychological distress and alcohol use in Australian adolescents over a period of declining consumption
Creators: name: Cerocchi, Natalie
name: Mojica Perez, Yvette
name: Livingston, Michael
name: Arunogiri, Shalini
name: Pennay, Amy
name: Callinan, Sarah
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 44
subject: Human society

description: Introduction: Youth drinking rates have declined over the past 15 years while self-reported psychological distress has increased, despite a well-recognised positive relationship between the two. The current study aimed to identify changes in the relationship between psychological distress and alcohol use in adolescents from 2007 to 2019. Methods: This study used survey responses from 6543 Australians aged 14–19 years who completed the National Drug Strategy Household Survey in 2007, 2010, 2013, 2016 or 2019. Logistic and multivariable linear regressions with interactions (psychological distress × survey wave) predicted any alcohol consumption, short-term risk and average quantity of standard drinks consumed per day. Results: Psychological distress was a positive predictor of alcohol use and this association remained stable across survey waves as alcohol consumption decreased. Discussion and Conclusions: The relationship between distress and alcohol consumption remained relatively steady, even as youth drinking declined and distress increased. The proportion of drinkers experiencing distress did not increase as consumption rates dropped, suggesting that the decline in youth drinking is occurring independently of the increase in self-reported and diagnosed mental health issues.