cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cell-specific targeting polymeric gene delivery carriers
Creators: name: Suh, Won-Hee
Publisher: name: University of Utah
Year: 2012
Subjects: Drug Delivery Systems
Polymeric Drugs

description: Cell-specific polymeric gene delivery carriers targeted to leukemia T cells and angiogenic endothelial cells, were designed and developed using anti-JL1 antibody and alpha-v-beta3/alpha-v-beta5 integrin-binding RCD-4C peptide as targeting moieties.  In the first part of this thesis, an angiogenic endothelial cell-targeting polymeric gene carrier was synthesized by conjugating RGD-4C peptide with the cationic polymer polyethyleneimine (PEI) using a heterobifunctional polyethylene glycol (PEG) linker. The incorporation of hydrophilic PEG into PEI improved poor physicochemical properties of DNA/PEI complexes; however, the extensive grafting of PEI with PEG was shown to inhibit DNA condensation process, significantly decreasing transfection efficiency. In in vitro transfection experiments, PEI-g-1PEG-RGD showed high specificity to angiogenic endothelial cells, compared to normal endothelial cells. Also PEI-g-1PEG-RGD exhibited approximately a five-fold increase in transfection with angiogenic endothelial cells over PEI homopolymer, probably due to an integrin-mediated internalization pathway.  In the second part of this thesis, a leukemia-specific polymeric gene delivery carrier was developed by carbohydrate site-directed modification of anti-JL1 antibody with the cationic polymer, polylysine (PLL). The composition and antigen binding affinity of anti-JL1 antibody-PLL conjugates were analyzed by amino acid analysis and flow cytometry respectively. In the experiments with Molt 4 (human leukemia T cells), anti-JL1 antibody-PLL/DNA complexes were efficiently internalized into the cytoplasm after a 4 hour incubation at 37°C and showed significantly higher in vitro transfection efficiency than PLL/DNA complexes and DNA/Lipofectin formulation. This high efficiency of anti-JL1 antibody-containing PLL might result from the targeting effect of receptor-mediated endocytosis induced by anti-JL1 antibody.
Economic Impact of COVID-19 on Michigan Agricultural Production Sectors
Creators: name: Miller, Steven R.
name: Malone, Trey
name: Schaefer, Aleks K.
name: Miller, Steven R.
name: Malone, Trey
name: Schaefer, Aleks K.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agricultural and Food Policy
subject: COVID19
subject: Agriculture
subject: Production
subject: Food
subject: Michigan

description: The COVID-19 pandemic caused dramatic shifts in the agricultural economy. This article estimates the economic impact of the pandemic on Michigan agricultural production. Our conceptual model focuses on differences in five aggregated agri-food supply chains: row crops, livestock, tree fruits, vegetables, and dairy. Assuming the COVID-19 economic impact is driven by commodity price changes and changes in the relative prices and volumes of food away from home and food at home, we estimate a model of costs to the Michigan economy. Our findings indicate that the pandemic decreased the overall economic output attributable to Michigan agriculture by 18.6%, with dairy and vegetable production being the hardest hit, experiencing 25.2% and 27.2% reductions in economic output, respectively. Results from our input-output analysis suggest that the Michigan economy experienced a decline of $2,186,268,000 of primary and secondary sales due to pandemic effects on agricultural producers.
Sonnenfleckenzeichnung Nr. 23404.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23441.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23409.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Low cost solution-based materials processing methods for large area OLEDs and OFETs
Creators: name: Jeong, Jonghwa
Publisher: name: University of Utah
Year: 2012
Subjects: Organic field effect transistor
Organic light emitting devices
Organic semiconductor
OLED
OFET

description: In Part 1, we demonstrate the fabrication of organic light-emitting devices (OLEDs) with precisely patterned pixels by the spin-casting of Alq3 and rubrene thin films with dimensions as small as 10　μm. The solution-based patterning technique produces pixels via the segregation of organic molecules into microfabricated channels or wells. Segregation is controlled by a combination of weak adsorbing characteristics of aliphatic terminated self-assembled monolayers (SAMs) and by centrifugal force, which directs the organic solution into the channel or well. This novel patterning technique may resolve the limitations of pixel resolution in the method of thermal evaporation using shadow masks, and is applicable to the fabrication of large area displays. Furthermore, the patterning technique has the potential to produce pixel sizes down to the limitation of photolithography and micromachining techniques, thereby enabling the fabrication of high-resolution microdisplays. The patterned OLEDs, based upon a confined structure with low refractive index of SiO2, exhibited higher current density than an unpatterned OLED, which results in higher electroluminescence intensity and eventually more efficient device operation at low applied voltages. We discuss the patterning method and device fabrication, and characterize the morphological, optical, and electrical properties of the organic pixels. In part 2, we demonstrate a new growth technique for organic single crystals based on solvent vapor assisted recrystallization. We show that, by controlling the polarity of the solvent vapor and the exposure time in a closed system, we obtain rubrene in orthorhombic to monoclinic crystal structures. This novel technique for growing single crystals can induce phase shifting and alteration of crystal structure and lattice parameters. The organic molecules showed structural change from orthorhombic to monoclinic, which also provided additional optical transition of hypsochromic shift from that of the orthorhombic form. An intermediate form of the crystal exhibits an optical transition to the lowest vibrational energy level that is otherwise disallowed in the single-crystal orthorhombic form. The monoclinic form exhibits entirely new optical transitions and showed a possible structural rearrangement for increasing charge carrier mobility, making it promising for organic devices. These phenomena can be explained and proved by the chemical structure and molecular packing of the monoclinic form, transformed from orthorhombic crystalline structure.
Sonnenfleckenzeichnung Nr. 23438.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Arriguttia Martinez 1960
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Arriguttia

description: ARRIGUTTIA Martínez, 1960
Arriguttia Martínez 1960: 97
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 158, DOI: 10.5281/zenodo.3678492
The Effectiveness of an intra-aortic balloon review class for nurses.
Creators: name: Phillips, Terry L
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: Critical Care

description: Evaluation of inservice education provided for nurses in a hospital setting is of concern to Nursing; educators.  This study evaluated an intra-aortic balloon review course provided for critical care nurses.  The three-hour course was designed according to â€œpropositions of learningâ€ suggested by a Nursing; educator-theorist.  The subjects consisted of fourteen registered nurses who attended an intro-aortic balloon review course.  A one-group pretest-posttest design was used.  There was a skills test and a written test.  Each test was a criterion-referenced evaluation of Nursing; competency in relation to the intra-aortic balloon pump.  The study demonstrated that the learning proposition could be operationalized in a Nursing; inservice program.  There was a significant increase in posttest scores over pretest scores, suggesting that learning was associated with the course.  Demographic variables did not significantly affect pretest scores, nor the amount of improvement in scores.
Hamartomas Hipotalâmicos: Correlação Clínico-Imagiológica Numa Série Pediátrica
Creators: name: Carvalho, Fábio Pires De
name: Pinto, Ana Rita
name: Cabral, Pedro
name: Ferreira, José Carlos
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Introdução: O hamartoma hipotalâmico é uma malformação não neoplásica benigna rara. É feita uma correlação entre os achados clínicos e imagiológicos em doentes pediátricos de um hospital terciário. Métodos: Análise retrospetiva de casos de hamartoma hipotalâmico diagnosticados em idade pediátrica, tendo como fonte o arquivo neuropatológico do serviço de pediatria de um hospital terciário de Lisboa. Resultados: Nos oito casos identificados, a idade média de apresentação inicial dos sintomas foi de 27 meses. Crises epiléticas foram a manifestação inicial em 50% dos casos, sendo as mais comuns as crises gelásticas. Puberdade precoce foi o sintoma inicial em apenas um caso. Em 25% dos casos, os hamartomas hipotalâmicos encontrados foram considerados do tipo para-hipotalâmico. Os restantes seis foram classificados como intra-hipotalâmicos. O eixo de maior diâmetro determinado tinha, em média, de 6 mm nos para-hipotalâmicos, sendo de cerca de 15,8 mm nos intra-hipotalâmicos. No segundo grupo, foram descritas em dois dos seis casos malformações da linha média encefálica, nomeadamente agenesia da comissura do corpo caloso. Discussão: Nesta série, pese embora a geral concordância com os dados disponíveis na bibliografia, a alta percentagem de crises epiléticas como forma de apresentação inicial, bem como a relação da influência dimensional do hamartoma hipotalâmico no desenvolvimento de puberdade precoce, são achados interessantes e a reter. Em crianças que se apresentam com puberdade precoce ou crises epiléticas, massas do terceiro ventrículo com características imagiológicas sugestivas devem suscitar um diagnóstico pré-operatório de hamartoma hipotalâmico.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Comparative studies of two-dimensional echocardiographic and 12-lead ECG findings in right heart enlargement.
Creators: name: Holmen, John Reynold
Publisher: name: University of Utah
Year: 2012
Subjects: Heart Hypertrophy
Ultrasound

description: This thesis project was designed to evaluate certain EG criteria presently used in the diagnosis of right heart enlargement.  Using a relatively new diagnostic tool, two-dimensional echocardiography as the "gold standard" in cardiac dimension sizing, 3 cases were  studied.  In 37 normal adults, the analysis of six two-dimensional echo parameters resulted in the following measurements of mean and standard deviation: RV area = 19.8 Â± 5.1 cm2; RV area/BSA = 10.5 Â± 2.5 cm2/m2; RA area = 13.4 Â± 2.9 cm2; RA area/BSA = 7.1 Â± 1.3 cm2/m2; RV/LV area ratio = 0.68 Â± 0.14; RA/LA area ratio = 0.93 Â± 0.16.  From this data, a population of 36 patients was defined as having enlargement if one or more measurements exceeded these means plus two standard deviations.  Following this classification, a number of parameters were measured on all cases, both normal and abnormal.  Through the use of t-tests, significant differences were found between the following ECG parameters: R wave amplitude in V1-V2; S wave amplitude in V5-V6; R/S ration in V1-V2; R/S ration in V5-V6; QRS axis deflection; P wave amplitude.  Linear regression analysis was then used to evaluate correlations of chamber dimensions with ECG measurements.  Poor correlation was found with 0.0 < r < 0.52.  To increase the predictive value of the ECG measurements, a multivariate discriminant analysis was performed which resulted in a 60% sensitivity and 90% specificity using the following ECG parameters; R wave in V1-V2; S wave in V5-V6; R/S ratio in V1/V2; QRS axis.  The resulting discriminant function was: Y = 0.02(X1)  +  0.074(X2) + 0.006(X3) + 0.0006(X4) - 0.48, where X1 to X4 are the above respective parameter measurements.  Subjects with Y > .511 were then classified as having right heart enlargement with the confidence range previously mentioned.  From this project, it has been shown  that multivariate ECG analysis is a potentially powerful technique for diagnosing right heart enlargement.  Furthermore, through the use of 2-D echocardiography, the potential now exists for the rapid collection of large data bases of previously difficult to obtain cardiac structural information.
Distributive justice in obstetrical/gynecological health care : an application of Rawls and Daniels
Creators: name: Kapsa, Christine Wessel
Publisher: name: University of Utah
Year: 2012
Subjects: Economics

description: Many women are not able to obtain needed obstretrical/-gynecological (OB/GYN) care due to an unjust distribution of health care resources.  A principle of distributive justice based on the work of Rawls and Daniels is proposed to correct this inequity.  Daniels posits a right to health care based of Rawls's fair equality of opportunity principles.  He further maintains such a right could be fulfilled by a multitiered health care system.  Empirical data derived from current OB/GYN care are used to demonstrate the link between such care and the preservation of a woman's fair equality of opportunity.  Further data show why a multitiered market system leaves many women without OB/GYN care.  OB/GYN care is divided into functional categories according to the goal it serves, either medical or social.  A right to a reasonable median of care is proposed.  The reasonable median would fund care necessary to preserve a fair equality of opportunity for all persons.  It would be a strictly egalitarian, single tier system.
Sonnenfleckenzeichnung Nr. 23394.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Seasonal underground thermal energy storage using smart thermosiphon arrays
Creators: name: Jankovich, Philip Martin
Publisher: name: University of Utah
Year: 2012
Subjects: Air-conditioning
Heat transfer
Phase change
Thermal energy storage
Thermosiphon arrays

description: With oil prices high, and energy prices generally increasing, the pursuit of more economical and less polluting methods of climate control has led to the development of seasonal underground thermal energy storage (UTES) using pump-assisted smart thermosiphon arrays (STAs). With sufficient thermal storage capacity, it is feasible to meet all air-conditioning and heating requirements with a trivial fuel or electrical input in regions with hot summers and cold winters. In this dissertation, it is described how STAs can provide seasonal energy storage to meet all climate control needs. STAs are analyzed and compared with current similar technologies. The objective of this research was to create a methodology to design STA systems for any cooling load in any climate. Full year simulations were performed to model the charging and discharging processes to minimize total pipe length. The modeling results were validated with analytical solutions and some experimental data. The model developed was successfully able to simulate the heat transfer in and out of the soil through thermosiphon pipes over the course of one year using actual weather data and loads. Based on initial modeling results, a pilot-scale thermosiphon system was implemented. A description of this system and limited temperature data is put forth in Chapter 4.
Sonnenfleckenzeichnung Nr. 23363.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Hipertricose do Pavilhão Auricular Neonatal e Diabetes Gestacional: Coincidência ou Algo Mais?
Creators: name: Rúbio, Catarina Godinho
name: Carvalho, Tânia
name: Queirós, Gustavo
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Síndrome Sincinética Mandíbulo-Palpebral de Marcus Gunn: Relato de Dois Casos
Creators: name: Azurara, Laura
name: Marques, Nadine
name: Sanches, Bruno
name: Queiroz, Ana Margarida
name: Ferreira, Maria Gomes
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: A síndrome sincinética mandíbulo-palpebral de Marcus Gunn caracteriza-se, classicamente, pela presença de ptose palpebral congénita que reverte com a mobilização da mandíbula. Admite-se que exista um mau direcionamento neuronal congénito dos axónios motores do nervo trigémeo do músculo pterigoideo externo (responsável pela depressão e protusão da mandíbula) para o músculo levantador da pálpebra, que condiciona a retração da pálpebra quando o doente contrai o músculo pterigoideo homolateral, por exemplo, durante os movimentos de sucção e abertura ou lateralização da mandíbula. O espetro de manifestações clínicas é amplo, podendo cursar com movimentos de elevação da pálpebra superior desencadeados pela mobilização da mandíbula, sem ptose. Descrevem-se dois casos clínicos de lactentes que apresentavam, desde o nascimento, movimentos de elevação da pálpebra superior direita síncronos com os movimentos de sucção, sem ptose palpebral. Os casos alertam para os aspetos clínicos da síndrome sincinética mandíbulo-palpebral, que permanece pouco conhecida entre a comunidade pediátrica.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Sonnenfleckenzeichnung Nr. 23524.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.12.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
IT TEXNOLOGIYALARDAN FOYDALANGAN HOLDA TURIZMNI RIVOJLANTIRISHDA OLIB BORILAYOTGAN ISLOHOTLAR
Creators: name: Musirmanov, Shohboz
Publisher: name: Zenodo
Year: 2024

description: Turizmni rivojlantirishda axborot texnologiyalari (IT) islohotlari turizm industriyasi faoliyatida inqilob qildi. Raqamli vositalar va platformalardan foydalangan holda sayyohlik tashkilotlari mijozlar tajribasini yaxshilashi, operatsiyalarni soddalashtirishi va marketing strategiyalarini yaxshilashi mumkin. Ushbu maqola IT islohotlarining turizmni rivojlantirishga ta'sirini o'rganib, sanoatning raqamli transformatsiyasidagi asosiy tendentsiyalar, muammolar va imkoniyatlarni yoritadi.
Atitudes e Comportamentos Sexuais na Adolescência: Um Estudo Pioneiro em Portugal no Âmbito do Ensino Privado
Creators: name: Pinto, Luisa
name: Reis, Marta
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Introdução: A vivência da sexualidade na adolescência está frequentemente associada ao início da atividade sexual, condicionando elevadas taxas de gravidez, de infeções sexualmente transmissíveis e de consequências psicológicas nefastas, com implicações pessoais, familiares e sociais marcantes. Esta é uma questão prioritária no âmbito da saúde pública. Este trabalho pretendeu avaliar atitudes e comportamentos sexuais de adolescentes de um colégio privado de Lisboa, comparando diferenças de género nessas atitudes e comportamentos. Métodos: Aplicou-se um questionário a 385 jovens, entre os 14 e os 19 anos, a frequentarem do 9º ao 12º ano de escolaridade. Resultados: Referiram ter iniciado vida sexual 27%, em média aos 15,5 anos. A moda do número de parceiros foi de um. Na primeira relação sexual, 95,5% utilizaram contraceção, principalmente o preservativo (91,8%) e na última relação sexual 96% utilizaram contraceção (preservativo 80%, método hormonal 59%). Referiram ter tido relações sexuais sob efeito de álcool ou drogas 9%. Verificou-se um início mais precoce da vida sexual e maior número de relações sexuais ocasionais nos rapazes. Também nas atitudes se verificaram diferenças, com as raparigas evidenciando maior preocupação contracetiva e os rapazes mostrando atitudes de maior permissividade, valorização do sexo e instrumentalização do parceiro. Discussão: Este estudo reforça a necessidade de uma educação sexual tendo presente as diferenças de género, com vista a uma vivência mais igualitária, mais responsável e mais gratificante da sexualidade.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Computer-based alerts for drug dosing in renal impairment
Creators: name: Pestotnik, Stanley Louis
Publisher: name: University of Utah
Year: 2012

description: The objective of this project was to develop computerized methods to monitor and recommend dosage changes of patients treated with excessive dosages of imipenem/cilastatin (imipenem) and to determine the incidence if imipenem-associated seizers.  A prospective, observational, and interventional study design was chosen for this project.  The study population consisted of all patients admitted to LDS Hospital and treated with imipenem from May 1, 1987 through October 1, 1992.  LDS Hospital, Salt Lake City, Utah, is a 520-bed tertiary care center associated with the University of Utah School of Medicine, Salt Lake City, Utah.  Computerized algorithms (knows as frames) were developed, on the hospital information system that exists at LDS Hospital, to identify and monitor patients receiving imipenem.  These frames screened the computer-stored medical records of all inpatient admission for prescription orders for imipenem.  Computer-based frames estimated the renal function of each imipenem-treated patient and when does were determined to be excessive an imipenem dosing frame alerted the investigator.  Additional computer-generated surveillance alerts identified patients who were receiving anticonvulsants concomitantly with imipenem or whose therapy reflected dosage changes in the previous 24 hours.  Each day a list of all imipenem-treated patients with alerts was reviewed by a clinical pharmacist and prescribing physicians were contacted if the computer-generated suggestions were clinically relevant.  From May1, 1987 to October 1, 1992 all hospital admissions (135,890) at LDS Hospital were prospectively monitored. During the study period 2,615 patients were treated with imipenem.  The following risk factors for imipenem-associated seizures were observed in the imipenem-treated population: abnormal renal function (70%), stroke (5%), head trauma (1%), and seizure disorder (0.5%).  The observational and interventional methods employed in  this study resulted in 82.3% of the patients receiving imipenem doses appropriate for their corresponding renal function.  During the  study period six seizures (0.23%) were detected in the imipenem-treated patients.  All six patients were receiving imipenem doses that were excessive for their renal function.  In conclusion, the 0.23% seizure rate that was observed in this investigation in lower than the 1-2% rate reported in the literature despite the fact that 76.5% of the patients who received imipenem had risk factors for seizures.  Appropriate dosing of imipenem result in a low rate of associated seizures.  Computer-assisted monitoring of imipenem doses, in relation to renal function, resulted in a reduced risk of seizures in this study.
Sonnenfleckenzeichnung Nr. 23521.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.12.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: Developments in bone tissue bioceramics: Effects of preparation on properties
Creators: name: Samson, Jason
Publisher: name: URMSE
Year: 2020

description: Bone tissue is the second most transplanted tissue each year. A demand for synthesized bone substitutes has led the development of materials that are biocompatible, bioactive, and bioabsorbable while also mechanically similar to bone tissue. Hydroxyapatite and calcium phosphate-based bioceramics have been the gold standard for substitute bone tissue development. Techniques have been developed such as formulation manipulation, freeze-drying, and 3D-printing gels that show promise in changing particle size and porosity. Higher porosity has been found to increase bioactivity, but also reduces compressive strength. Simple statistical methods and novel 3D-printing techniques have been shown to improve ultimate compressive strength and optimize scaffold formulas.
Arriguttia brevissima
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Arriguttia
Arriguttia brevissima

description: Arriguttia brevissima (Arrow, 1911)
Cyclocephala brevissima Arrow 1911b: 175 (French Guiana, Brazil)
Distribution. Guyana: Endrödi 1966a: 58, 1985a: 26; Lachaume 1992: 16; Moore et al. 2018b: 120. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini, eastern bank Corantijn opposite Arapahu Resort, (3°27′N, 57°37.5′W). 14/ 21-II-2011. A. J. Hielkema. In FIT in forest.); RMNH. French Guiana: Arrow 1911b: 175 (as Cyclocephala brevissima); Endrödi 1966a: 58; Duranton 2011: 11 (as Arrigutia [sic] brevissima); Ponchel 2011: 60; Dupuis 2016b: 109 (as Ariguttia [sic] brevissima); Moore et al. 2018b: 120. “Guianas”: Arrow 1937b: 8 (as Cyclocephala brevissima); Blackwelder 1944: 251 (as Cyclocephala brevissima). Brazil (NA): Arrow 1911b: 175 (as Cyclocephala brevissima), 1937b: 8 (as Cyclocephala brevissima); Blackwelder 1944: 251 (as Cyclocephala brevissima); Martínez 1960: 98 (NA); Endrödi 1966a: 58, 1985a: 26; Lachaume 1992: 16; Moore et al. 2018b: 120.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 158, DOI: 10.5281/zenodo.3678492
Chemistry of oil production from tar sands
Creators: name: Hanks, Kevin Clair
Publisher: name: University of Utah
Year: 2012
Subjects: Oil sands, Utah

description: Tar sands from three Utah deposits were processed in a small-scale two-stage fluidized-bed reactor.  The oil products obtained were analyzed for several physical and chemical properties, including viscocity, refractive index, density, sulfur content, distillation data, and nmr spectra.  The effluent gas was analyzed for individual components, and coke was also analyzed for yeild values.
Hepatoesplenomegalia Neonatal: Para Além das Causas Comuns
Creators: name: Romão, Patrícia
name: Durão, Filipa
name: Janeiro, Patrícia
name: Saldanha, Joana
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: As causas de hepatoesplenomegalia no período neonatal são diversas e determinam diferentes abordagens, pelo que o seu diagnóstico diferencial é essencial. Apresenta-se o caso clínico de um recém-nascido com 2 dias de vida, internado por hepatoesplenomegalia e trombocitopenia. Na observação destacava-se icterícia, opistótonos, polipneia e marcada hepatoesplenomegalia. Após exclusão de causas comuns e tratáveis de hepatoesplenomegalia neonatal, a presença de citopenias e envolvimento neurológico conduziu à investigação da doença de Gaucher, confirmada pela identificação da mutação c.1448T>C em homozigotia no gene GBA. Aos 20 dias de vida teve alta clinicamente estável e com tratamento de suporte. Posteriormente verificou-se uma evolução rápida da doença, tendo vindo a falecer aos 2 meses. Com a descrição deste caso os autores pretendem salientar a importância de considerar a doença de Gaucher no diagnóstico diferencial de hepatoesplenomegalia neonatal.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Managing provenance for knowledge discovery and reuse
Creators: name: Koop, David Allen
Publisher: name: University of Utah
Year: 2012
Subjects: Provenance
VisTrails
Workflow

description: Serving as a record of what happened during a scientific process, often computational, provenance has become an important piece of computing. The importance of archiving not only data and results but also the lineage of these entities has led to a variety of systems that capture provenance as well as models and schemas for this information. Despite significant work focused on obtaining and modeling provenance, there has been little work on managing and using this information. Using the provenance from past work, it is possible to mine common computational structure or determine differences between executions. Such information can be used to suggest possible completions for partial workflows, summarize a set of approaches, or extend past work in new directions. These applications require infrastructure to support efficient queries and accessible reuse. In order to support knowledge discovery and reuse from provenance information, the management of those data is important. One component of provenance is the specification of the computations; workflows provide structured abstractions of code and are commonly used for complex tasks. Using change-based provenance, it is possible to store large numbers of similar workflows compactly. This storage also allows efficient computation of differences between specifications. However, querying for specific structure across a large collection of workflows is difficult because comparing graphs depends on computing subgraph isomorphism which is NP-Complete. Graph indexing methods identify features that help distinguish graphs of a collection to filter results for a subgraph containment query and reduce the number of subgraph isomorphism computations. For provenance, this work extends these methods to work for more exploratory queries and collections with significant overlap. However, comparing workflow or provenance graphs may not require exact equality; a match between two graphs may allow paired nodes to be similar yet not equivalent. This work presents techniques to better correlate graphs to help summarize collections. Using this infrastructure, provenance can be reused so that users can learn from their own and others' history. Just as textual search has been augmented with suggested completions based on past or common queries, provenance can be used to suggest how computations can be completed or which steps might connect to a given subworkflow. In addition, provenance can help further science by accelerating publication and reuse. By incorporating provenance into publications, authors can more easily integrate their results, and readers can more easily verify and repeat results. However, reusing past computations requires maintaining stronger associations with any input data and underlying code as well as providing paths for migrating old work to new hardware or algorithms. This work presents a framework for maintaining data and code as well as supporting upgrades for workflow computations.
Olfactory display for the treadport active wind tunnel
Creators: name: Lefler, Price
Publisher: name: University of Utah
Year: 2012
Subjects: Olfactory display
TreadPort
Wind tunnel
Utah TreadPort Virtual Environment
UUTVE

description: This thesis discusses the development of an olfactory display for the University of Utah TreadPort Virtual Environment (UUTVE). The goal of the UUTVE is to create a virtual environment that is as life like as possible by communicating to the user as many of the sensations felt in moving around in real the world as possible, while staying within the confines of the virtual environment's workspace. The UUTVE has a visual display, auditory display, a locomotion interface and wind display. With the wind display, it is possible to create an effective olfactory display that does not have some of the limitations associated with many of the current olfactory displays. The inclusion of olfactory information in virtual environments is becoming increasingly common as the effects of including an olfactory display show an increase in user presence. The development of the olfactory display for the UUTVE includes the following components: the physical apparatus for injecting scent particles into the air stream, the development of a Computational Fluid Dynamics (CFD) model with which to control the concentration of scent being sensed by the user, and user studies to verify the model and show as proof of concept that the wind tunnel can be used to create an olfactory display. The physical apparatus of the display consists of air atomizing nozzles, solenoids for controlling when the scents are released, containers for holding the scents and a pressurized air tank used to provide the required air to make the nozzles work. CFD is used model the wind flow through the TPAWT. The model of the wind flow is used to simulate how particles advect in the wind tunnel. These particle dispersion simulations are then used to create a piecewise model that is able to predict the scent's concentration behavior as the odor flows through the wind tunnel. The user studies show that the scent delivery system is able to display an odor to a person standing in the TPAWT. The studies also provided a way to measure the time it takes for a person to recognize an odor after it has been released into the air stream, and also the time it takes for a user to recognize that the odor is no longer present.
Síndrome Induzida por Fármacos com Eosinofilia e Sintomas Sistémicos (DRESS) Associada aos Antituberculosos: O Papel da Imunoglobulina Endovenosa
Creators: name: Rangel, Maria Adriana
name: Moreira, Diana
name: Duarte, Raquel
name: Costa, Herculano
name: Carvalho, Isabel
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: A síndrome induzida por fármacos com eosinofilia e sintomas sistémicos é uma forma rara de hipersensibilidade a fármacos com desfecho potencialmente fatal. Descreve-se o caso clínico de uma adolescente sob tratamento para tuberculose ativa, que iniciou quadro de vómitos, diarreia, astenia e exantema maculopapular pruriginoso à sexta semana de tratamento. Ao sexto dia de doença, iniciou febre elevada e agravamento do exantema. Apresentava linfócitos atípicos circulantes e hepatite, sendo suspenso o tratamento com antituberculosos. A investigação etiológica autoimune, infeciosa viral e bacteriana foi negativa. Ao décimo sétimo dia de doença, pela persistência da febre, eritema morbiliforme com áreas vasculíticas, compromisso da função hepática, derrame pleural bilateral e eosinofilia (1690 células/μL) foi diagnosticada síndrome induzida por fármacos com eosinofilia e sintomas sistémicos e instituído tratamento com imunoglobulina endovenosa, com melhoria clínico-analítica progressiva. Esta síndrome é uma complicação rara do tratamento com antituberculosos, sendo a imunoglobulina endovenosa uma terapêutica eficaz em alternativa aos corticosteroides.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 3 (2017)
Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model
Creators: name: Meola, Stacy D.
Publisher: name: University of Utah
Year: 2012
Subjects: Heparin
Thrombus

description: Anticoagulant and antiplatelet agents are currently being used clinically during episodes of unstable angina and non-Q-wave myocardial infarctions to stop thrombus formation to decrease morbidly and mortality.  In vitro and ex vivo stent models were developed to assess thrombus formation, platelet incorporation and emboli development utilizing combinations of anticoagulant (heparin) and antiplatelet (Aggrastat ®) agents.  The ex vivo model assessed thrombus and emboli formation in an ovine shunt model for nine drug combinations using gravimetric analysis and an unique light scattering microemboli detector (LSMS) to assess emboli in flowing blood.  The in vitro model compared five therapy relationships using a one-pass bovine blood model using gravimetric analysis, radio-labeled platelets, and the LSMD.  The results confirm that a combination therapy utilizing an anticoagulant and antiplatelet drug therapy the total thrombus weight and emboli produced can be decreased as compared to using an anticoagulant alone.
Detection and characterization of antibodies against mouse melanoma MB-16 by immunofluorescence
Creators: name: Kato, Kenneth Hayami
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Mice
subject: Microbiology
subject: FOS: Biological sciences

description: Tumor-specific antibodies to mouse melanoma MB-16 were detected by Immunofluorescence in the sera of C57BL/6J mice, the inbred host strain.  Fixed tumor cells grown in tissue culture on cover-slips were employed as target cells for immunofluorescent tests.  Fluorescence of the cytoplasm of tumor cells was an indication of a positive reaction.  Antibody was detectable on the 5th post-challenge day in mice injected (6 x 10[5]) s.c. with MB-16 cells isolated from subcutaneous transplants. The antibody reached a maximum titer of 1:4 on day 10 and this titer persisted until the 21st day following the initial injection.  Tumors formed on tails of mice injected s.c. with 6 x 10[5] viable tumor cells were removed by tail amputation 35 days post-challenge.  Prior to tumor removal, titers gradually increased from 1:4 to 1:16.  The incidence of antibody also increased from 80% after 1 week to 100% in the 5th week after the challenge dose.  Following tumor removal, titers fell to 1:4 and then gradually declined.  Antibody was still detectable in the serum of mice 19 weeks following removal of the tumor.  The antibody persisted in the presence of overt metastatic lesions as well as in apparent absence of tumor.  Five of nine (56%) of sera from human patients with malignant melanoma were reactive at low titers (1:2) on MB-16 target cells.  Six of nine (78%) melanoma sera were positive on human melanoma cells.  The antibody reached titers of 1:8.  With on exception, the serum from a patient with choriocarcinoma, 26 sera from patients with disorders unrelated to malignant melanoma, and 20 blood bank sera were either non-reactive or non-specific for human melanoma target cells.  The specificity of the fluorescent staining reaction was determined by absorption as sera with heterologous antigens (normal and neoplastic cells), one-step inhibition procedures, and test target cells from different tissue culture cell lines.  Absorption of sera with surface membrane preparations from MB-16 cells indicated the absence of antibodies to surface antigens.
Sonnenfleckenzeichnung Nr. 23366.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Carta ao Editor
Creators: name: Pinto, Armando
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Venho por este meio comentar o artigo publicado na Acta Pediátrica Portuguesa com o título “Oncologia Pediátrica.... Futuro ou Regresso ao Passado....”, da autoria da Dra. Filomena Pereira
description: Portuguese Journal of Pediatrics, Vol. 48 No. 3 (2017)
Sonnenfleckenzeichnung Nr. 23361.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sigelschlüssel der archäologischen Literatur SAL
Creators: name: Müller, Otto Von
name: Nagel, Wolfram
name: Strommenger, Eva
Publisher: name: Acta Praehistorica et Archaeologica
Year: 2022

description: Acta Praehistorica et Archaeologica, Bd. 9/10 1978/1979(1979)