cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comprehensive Assessment of the Dynamics of Banana Chilling Injury by Advanced Optical Techniques
Creators: name: Herppich, Werner B.
name: Zsom, Tamás
Publisher: name: Basel : MDPI
Year: 2021
Subjects: subject: Chlorophyll‐fluorescence analysis
subject: Fluorescence imaging
subject: NDVI
subject: Photosynthesis
subject: Postharvest physiology
subject: Shelf‐life
subject: Spectral analyses
subject: Spectral indices
subject: 600
subject: 570
subject: 620

description: Green‐ripe banana fruit are sensitive to chilling injury (CI) and, thus, prone to postharvest quality losses. Early detection of CI facilitates quality maintenance and extends shelf life. CI affects all metabolic levels, with membranes and, consequently, photosynthesis being primary targets. Optical techniques such as chlorophyll a fluorescence analysis (CFA) and spectroscopy are promising tools to evaluate CI effects in photosynthetically active produce. Results obtained on bananas are, however, largely equivocal. This results from the lack of a rigorous evaluation of chilling impacts on the various aspects of photosynthesis. Continuous and modulated CFA and imaging (CFI), and VIS remission spectroscopy (VRS) were concomitantly applied to noninvasively and comprehensively monitor photosynthetically relevant effects of low temperatures (5 °C, 10 °C, 11.5 °C and 13 °C). Detailed analyses of chilling‐related variations in photosynthetic activity and photoprotection, and in contents of relevant pigments in green‐ripe bananas, helped to better understand the physiological changes occurring during CI, highlighting that distinct CFA and VRS parameters comprehensively reflect various effects of chilling on fruit photosynthesis. They revealed why not all CFA parameters can be applied meaningfully for early detection of chilling effects. This study provides relevant requisites for improving CI monitoring and prediction.
НЕОБХОДИМОСТЬ ПРИМЕНЕНИЯ НОВЫХ МОДЕЛЕЙ ОЦЕНКИ РИСКА ВЕРОЯТНОСТИ БАНКРОТСТВА КОМПАНИИ В СОВРЕМЕННЫХ УСЛОВИЯХ
Creators: name: БЖАССО А.А.
name: КУЗЬМИНОВА В.Г.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ВЕРОЯТНОСТЬ БАНКРОТСТВА
ОЦЕНКА
МОДЕЛИ
АНАЛИЗ ФИНАНСОВОГО СОСТОЯНИЯ
МЕТОДЫ ПРОГНОЗИРОВАНИЯ
НЕСОСТОЯТЕЛЬНОСТЬ
КРИЗИС
ДИАГНОСТИКА
PROBABILITY OF BANKRUPTCY
ASSESSMENT
MODELS
FINANCIAL CONDITION ANALYSIS
FORECASTING METHODS
INSOLVENCY
CRISIS
DIAGNOSTICS

description: В статье обоснованна необходимость прогнозирования вероятности банкротства компаний. Описаны отечественные и зарубежные модели оценки и прогнозирования вероятности банкротства. Рассмотрены преимущества, недостатки моделей оценки и прогнозирования вероятности банкротства зарубежных и отечественных авторов. Обоснована необходимость применения моделей оценки вероятности банкротства в России в современных условиях.
Sonnenfleckenzeichnung Nr. 176.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.07.1996, 10:45, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
On vanishing theorems for Higgs bundles
Creators: name: Cardona, S. A. H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We introduce the notion of Hermitian Higgs bundle as a natural generalization of the notion of Hermitian vector bundle and we study some vanishing theorems concerning Hermitian Higgs bundles when the base manifold is a compact complex manifold. We show that a first vanishing result, proved for these objects when the base manifold was Kähler, also holds when the manifold is compact complex. From this fact and some basic properties of Hermitian Higgs bundles, we conclude several results. In particular we show that, in analogy to the classical case, there are vanishing theorems for invariant sections of tensor products of Higgs bundles. Then, we prove that a Higgs bundle admits no nonzero invariant sections if there is a condition of negativity on the greatest eigenvalue of the Hitchin-Simpson mean curvature. Finally, we prove that invariant sections of certain tensor products of a weak Hermitian-Yang-Mills Higgs bundle are all parallel in the classical sense.
description: 10 Pages, some typos corrected and minor changes
title: Pathogenic paralogous variants can be used to apply the ACMG PS1 and PM5 variant interpretation criteria
Creators: name: Tobias
name: Ivaniuk, Alina
name: Pérez-Palma, Eduardo
name: MONTANUCCI, LUDOVICA
name: Cohen, Stacey
name: Smith, Lacey
name: Parthasarathy, Shridhar
name: Helbig, Ingo
name: Nothnagel, Michael
name: May, Patrick
name: Lal, Dennis
Publisher: name: LCSB
Year: 2023

description: Purpose The majority of missense variants in clinical genetic tests are classified as variants of uncertain significance. Broadening the evidence of the PS1 and PM5 criteria has the potential to increase conclusive variant interpretation. Methods We hypothesized that incorporation of pathogenic missense variants in conserved residues across paralogous genes can increase the number of variants where ACMG PS1/PM5 criteria can be applied. We mapped over 2.5 million pathogenic and general population variants from ClinVar, HGMD, and gnomAD databases onto 9,990 genes and aligned these by gene families. Subsequently, we developed a novel framework to extend PS1/PM5 by incorporating pathogenic paralogous variants annotations (para-PS1/PM5). Results We demonstrate that para-PS1/PM5 criteria increase the number of classifiable amino acids 3.6-fold compared to PS1 and PM5. Across all gene families with at least two disease- associated genes, the calculated likelihood ratios suggest moderate evidence for pathogenicity. Moreover, for 36 genes, the extended para-PS1/PM5 criteria reach strong evidence level. Conclusion We show that single pathogenic paralogous variants incorporation at paralogous protein positions increases the applicability of the PS1 and PM5 criteria, likely leading to a reduction of variants of uncertain significance across many monogenic disorders. Future iterations of the ACMG guidelines may consider para-PS1 and para-PM5.
ОРГАНИЗАЦИЯ ВНУТРЕННЕГО КОНТРОЛЯ НА ПРЕДПРИЯТИЯХ
Creators: name: ЧЕРЕДНИКОВА А.А.
name: КУЗЬМИЩЕВ О.С.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ВНУТРЕННИЙ КОНТРОЛЬ
РЕВИЗИЯ
ПРЕДПРИЯТИЕ
СЛУЖБА ВНУТРЕННЕГО КОНТРОЛЯ
ЗАТРАТЫ
INTERNAL CONTROL
AUDIT
COMPANY
INTERNAL CONTROL SERVICE
COSTS

description: В данной статье раскрыто понятие внутреннего контроля, а также определена его роль в деятельности предприятия. При условиях современного существования каждого предприятия необходим внутренний контроль для того, чтобы проверять эффективность, производительность и результативность хозяйственной деятельности организации, а также проверять достоверность бухгалтерской финансовой и иной отчетности и соблюдение предприятием законодательства Российской Федерации.
title: Microglia: In Health and Disease
Creators: name: Shilauni Dadwal
name: Michael Heneka
Publisher: name: LCSB
Year: 2023

description: Microglia, the resident immune cells of the Central Nervous System (CNS), have received significant attention due to their critical roles in maintaining brain homeostasis and mediating cerebral immune responses. Understanding the origin of microglia has been a subject of great interest and emerging evidence suggests microglia consist of multiple subpopulations with unique molecular and functional characteristics. These subpopulations of microglia may exhibit specialized roles in response to different environmental cues as in disease conditions. The newfound understanding of microglial heterogeneity has significant implications for elucidating their roles in both physiological and pathological conditions. In the context of disease, microglia have been studied rigorously as it plays a very important role in neuroinflammation. Dysregulated microglial activation and function contribute to chronic inflammation. Further exploration of microglial heterogeneity and their interactions with other cell types in the CNS will undoubtedly pave the way to novel therapeutic strategies targeting microglia-mediated pathologies. In this review, we will discuss the latest advances in the field of microglia research, focusing specifically on their origin, subpopulations, the type of microglia population present in the neurodegenerative diseases brain, and how microglia get regulated in the healthy CNS.
ОПЫТ СОЗДАНИЯ КОМПЛЕКСНОЙ ЦИФРОВОЙ МОДЕЛИ СЕТИ МАГАЗИНОВ ОБЩЕСТВЕННОГО ПИТАНИЯ СРЕДСТВАМИ HIVEUP OBJECTS
Creators: name: КУЛИКОВ В.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ЦИФРОВОЕ МОДЕЛИРОВАНИЕ
РОЗНИЧНАЯ ТОРГОВЛЯ
ПРОДОВОЛЬСТВЕННЫЙ РИТЕЙЛ
СЕТЬ ОБЩЕСТВЕННОГО ПИТАНИЯ
ОПЫТ ОПТИМИЗАЦИИ УПРАВЛЕНИЯ
ДЕКОМПОЗИЦИЯ ПРОБЛЕМ БИЗНЕСА
ТАЙМ-МЕНЕДЖМЕНТ
БИЗНЕС-ПРОЦЕССЫ
DIGITAL MODELING
RETAIL TRADE
FOOD RETAIL
PUBLIC CATERING NETWORK
MANAGEMENT OPTIMIZATION EXPERIENCE
DECOMPOSITION OF BUSINESS PROBLEMS
TIME MANAGEMENT

description: В статье описан опыт формирования комплексной цифровой модели сети продовольственного ритейла при помощи инструментов, доступных в веб-приложении HiveUP Objects. Отражен выбранный нами порядок структурирования модели, описаны интегрированные структуры, уделено внимание значимым особенностям моделирования отдельных структур, в частности бизнес-процессов. В качестве примеров приведены некоторые финансовые, кадровые и организационные показатели, а также описаны принципы их создания и интеграции в модель. Также приведены данные сравнения, позволяющие оценить эффективность использования выбранного типа моделирования бизнес-процессов при создании нового торгового объекта по сравнению со стандартными средствами декомпозиции сложных проблем бизнеса, требующих анализа и учета большого количества (несколько десятков или сотен) факторов. В статье описано и аргументировано применение нескольких инструментов моделирования и уделено внимание методологии, применяемой для создания модели в веб приложении.
Data Management and the Role of Librarians
Creators: name: Smith, Plato
name: Gonzalez, Sara
Publisher: name: Zenodo
Year: 2019
Subjects: Data management librarian
Research collaborations
Socio-technical data management
The Carpentries at UF
UF Data science & informatics

description: ‘Research Data Science’ is defined by CODATA-RDA as an ensemble of (1) Open Science principles and practices (FAIR) and research data management and curation skills, (2) the use of a range of data platforms and infrastructures, (3) large scale analysis, (4) statistics, (5) visualization and modeling techniques, (6) software development and annotation, and (7) more.  Data management and the role of librarians must now include developing expertise with and training faculty, students, and staff on “research data science” directly and/or indirectly through collaborative library/faculty partnerships.  To meet this need, librarians at the University of Florida have developed a new research support service called Academic Research Consulting & Services (ARCS) to assist faculty, students, and staff with their data management and research needs.  The library-centered UF Data Management and Curation Working (DMCWG) and ARCS work in collaborative partnerships with the UF Informatics Institute, UF Data Carpentry Club (https://github.com/UF-Carpentry), and UF Data Science & Informatics (DSI) undergraduate student organization to provide support to pre- and post-grant research and teaching.  This new role of librarians is to facilitate library/faculty collaborations and broker resources that contribute to the facilitation of promulgating ‘research data science’ skills at scale for their respective institutions.  The paper will discuss the ongoing outreach activities, inter-departmental collaborations, and future goals or leveraging capacity, infrastructure, and resources to develop and teach research data science at scale within an institution’s current organizational culture. One of the main goals of this paper is to highlight the importance and significance of developing successful library/faculty collaborative relationships built on character, integrity, and humility as the cornerstones for the roles of librarians in promoting good data management and FAIR principles.
description: Members of the UF George A. Smathers Libraries Data Management and Curation Working Group, The Carpentries @ UF, UF DSI, UF Academic Research Consulting & Services, and GreyNet contributed to the development of this presentation.
Sonnenfleckenzeichnung Nr. 275.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.11.1996, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 2.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
title: ShinyTPs: Curating transformation products from text mining results
Creators: name: Palm, Emma Helena
name: CHIRSIR, PARVIEL
name: Krier, Jessy
name: Thiessen, Paul
name: Zhang, Jian
name: Bolton, Evan
name: Schymanski, Emma
Publisher: name: LCSB
Year: 2023

description: Transformation product (TP) information is essential to accurately evaluate the hazard compounds pose to human health and the environment. However, information about transformation products (TPs) is often limited, and existing data is often not fully Findable, Accessible, Interoperable and Reusable (FAIR). FAIRifying existing TP knowledge is a relatively easy path towards improving access to data for identification workflows and machine learning- based algorithms alike. ShinyTPs has been developed to curate existing transformation information derived from text mined data within the PubChem database. The app (available as an R package) visualizes the text-mined chemical names to facilitate user validation of the automatically extracted reactions. ShinyTPs was applied to a case study using 436 tentatively identified compounds to prioritize TP retrieval. This resulted in 645 (associated with 496 compounds), of which 319 were not previously available. in the same water sample using patron. In total 74 compounds from the library were identified The curated reactions were added to the PubChem transformations library which was used as a TP suspect list for identification of TP 25% of which were curated using ShinyTPs showing that the app can significantly improve TP identification in non-target analysis workflows.
Sonnenfleckenzeichnung Nr. 32.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.02.1996, 08:45, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Development of Biorefineries in the Bioeconomy: A Fuzzy-Set Qualitative Comparative Analysis among European Countries
Creators: name: Ding, Zhengqiu
name: Grundmann, Philipp
Publisher: name: Basel : MDPI
Year: 2021
Subjects: subject: Bioeconomy development
subject: Biorefineries
subject: Configurations of condi-tions
subject: Fuzzy-set
subject: Qualitative comparative analysis
subject: Transition framework
subject: 333.7
subject: 690

description: This study aims to identify the configurational conditions that characterize the establish-ment of biorefineries in 20 European countries. After determining the conditions which support a bioeconomy transition, secondary data from national sources are used to represent their existing conditions within respective countries. Then, a fuzzy-set qualitative comparative analysis is em-ployed to compare and contrast the effect of varying combinations of the selected conditions on the development of biorefineries. The conditions chosen include coherent bioeconomy strategies, network intensity of regional bioclusters, intellectual capital, and natural resource availability. Our results reveal that the configuration of a coherent bioeconomy strategy, sizable public spending on R&D, abundant biomass supply, and a high level of network intensity is sufficient to explain the pro-nounced biorefineries development among some European countries. We recommend that countries with fragmented approaches review and redesign the policy and regulatory framework to create a holistic and consistent bioeconomy strategy, taking into account the configurations of conditions as an important prerequisite. In particular, factors such as the lack of best practice examples, the low level of public spending on research and development, the economic capacities for a skilled workforce in addition to the sustainable supply of raw materials should be addressed as focal points.
title: Courage, compassion and connection, and the journey to healing: exploring cancer pre-diagnosis for Nunatsiavut Inuit
Creators: name: Bent, Jennifer E.
Publisher: name: Memorial University of Newfoundland
Year: 2023

description: Cancer is a chronic disease that has become increasingly prevalent in Indigenous populations within recent decades in Canada. Many risk factors contribute to the high rates of cancer for Indigenous peoples. Indigenous peoples have endured a history of colonialism, loss of culture, and dispossession of land. Indigenous peoples in the country present with later-stage cancers. This project was led by the Nunatsiavut Government in collaboration with the other Indigenous governments and organizations in Labrador: NunatuKavut Community Council, Mushuau Innu First Nation, and Sheshatshiu Innu First Nation, and explored the journey one must undergo to be diagnosed with cancer in Labrador, called the pre-diagnosis journey. Culturally safe approaches to data collection were used. We adopted a decolonizing approach with qualitative methods. This thesis will focus on findings from Nunatsiavut communities. Sharing circles and interviews were conducted with n= 32 participants. Thematic coding resulted in six themes: 1) Access and Supports; 2) Prolonged Investigation; 3) Travel; 4) Communication; 5) Fear and Anxiety; and 6) Being your own Health Advocate. Patients discussed challenges they encountered during their pre-diagnosis journey, and ways to improve their experience. There is a need for cultural-safety training for healthcare workers, a local cancer support group, accessible mental health services and educational materials about cancer. This thesis can be used to inform policy recommendations to enhance healthcare, and increase awareness of useful resources that can improve the pre-diagnosis journey.
Additional file 7 of Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells
Creators: name: Semina, Svetlana E.
name: Pal, Purab
name: Kansara, Nidhi S.
name: Huggins, Rosemary J.
name: Alarid, Elaine T.
name: Greene, Geoffrey L.
name: Frasor, Jonna
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 7: Supplemental Table 6 showing results of Functional Enrichment Analysis of NFκB gene signatures in integrated MCF-7 cell populations from different laboratories.
ТЕОРЕТИЧЕСКИЕ И ОРГАНИЗАЦИОННО-ПРАВОВЫЕ АСПЕКТЫ НАЛОГОВОГО КОНТРОЛЯ В ФОРМЕ ВЫЕЗДНЫХ НАЛОГОВЫХ ПРОВЕРОК
Creators: name: ИСАКОВ А.Х.
name: МИШАЕВА Т.С.-Х.
name: КУРБАНОВ С.А.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: НАЛОГОВЫЙ КОНТРОЛЬ
ВЫЕЗДНАЯ НАЛОГОВАЯ ПРОВЕРКА
НАЛОГОВЫЕ ОРГАНЫ
БЮДЖЕТ
НАЛОГОВЫЙ МОНИТОРИНГ
НАЛОГОВЫЕ РИСКИ
TAX CONTROL
ON-SITE TAX AUDIT
TAX AUTHORITIES
BUDGET
TAX MONITORING
TAX RISKS

description: В статье исследованы теоретические основы налогового контроля, дана авторская трактовка понятия «налоговый контроль», рассмотрены формы налогового контроля, такие как выездная налоговая проверка и налоговый мониторинг. Обозначены основные задачи и этапы проведения выездной налоговой проверки. Именно выездная налоговая проверка используется в роли ключевых инструментов налогового контроля, который является составляющей части налоговой системы.
Sonnenfleckenzeichnung Nr. 166.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.07.1996, 08:30, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
UAV Oblique Imagery with an Adaptive Micro-Terrain Model for Estimation of Leaf Area Index and Height of Maize Canopy from 3D Point Clouds
Creators: name: Li, Minhui
name: Shamshiri, Redmond R.
name: Schirrmann, Michael
name: Weltzien, Cornelia
name: Shafian, Sanaz
name: Laursen, Morten Stigaard
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: 3D point cloud from photogrammetry
subject: Crop phenotyping
subject: Decision making in crop production
subject: Leaf area index (LAI)
subject: Precision agriculture
subject: UAV remote sensing
subject: 630
subject: 640
subject: 570

description: Leaf area index (LAI) and height are two critical measures of maize crops that are used in ecophysiological and morphological studies for growth evaluation, health assessment, and yield prediction. However, mapping spatial and temporal variability of LAI in fields using handheld tools and traditional techniques is a tedious and costly pointwise operation that provides information only within limited areas. The objective of this study was to evaluate the reliability of mapping LAI and height of maize canopy from 3D point clouds generated from UAV oblique imagery with the adaptive micro-terrain model. The experiment was carried out in a field planted with three cultivars having different canopy shapes and four replicates covering a total area of 48 × 36 m. RGB images in nadir and oblique view were acquired from the maize field at six different time slots during the growing season. Images were processed by Agisoft Metashape to generate 3D point clouds using the structure from motion method and were later processed by MATLAB to obtain clean canopy structure, including height and density. The LAI was estimated by a multivariate linear regression model using crop canopy descriptors derived from the 3D point cloud, which account for height and leaf density distribution along the canopy height. A simulation analysis based on the Sine function effectively demonstrated the micro-terrain model from point clouds. For the ground truth data, a randomized block design with 24 sample areas was used to manually measure LAI, height, N-pen data, and yield during the growing season. It was found that canopy height data from the 3D point clouds has a relatively strong correlation (R2 = 0.89, 0.86, 0.78) with the manual measurement for three cultivars with CH90 . The proposed methodology allows a cost-effective high-resolution mapping of in-field LAI index extraction through UAV 3D data to be used as an alternative to the conventional LAI assessments even in inaccessible regions.
ЛОКАЛЬНЫЕ ЕСТЕСТВЕННЫЕ МОНОПОЛИИ КАК ВАЖНЫЙ ЭЛЕМЕНТ РАЗВИТОЙ РЫНОЧНОЙ ЭКОНОМИКИ
Creators: name: МУСАЕВА Р.У.
name: КУРБАНОВ С.А.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ЦЕНА
ТАРИФ
РЕГУЛИРОВАНИЕ
ЭКОНОМИКА
АНАЛИЗ
СУБЪЕКТ
PRICE
TARIFF
REGULATION
ECONOMY
ANALYSIS
ENTITY

description: Важным атрибутом улучшения/снижения качества жизни населения, а также неотъемлемой частью развитой рыночной экономики региона, страны в целом, являются локальные естественные монополии. Проблемы регулирования в данной сфере со стороны государства в лице Федеральной антимонопольной службы заслуживают пристального внимания. В данном исследовании охарактеризованы локальные естественные монополии, проведен сравнительный анализ цен и тарифов на коммунальные услуги в регионах СКФО на 2020 г., приведены соответствующие предложения.
ТАРИФООБРАЗОВАНИЕ КАК МЕТОД РЕГУЛИРОВАНИЯ ЕСТЕСТВЕННЫХ МОНОПОЛИЙ
Creators: name: МУСАЕВА Р.У.
name: КУРБАНОВ С.А.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ТАРИФ
МЕТОД
АНАЛИЗ
ЕСТЕСТВЕННЫЕ МОНОПОЛИИ
СУБЪЕКТ
TARIFF
METHOD
ANALYSIS
NATURAL MONOPOLIES
SUBJECT

description: История государственного регулирования рынков естественных монополий нашла широкое отражение в работах представителей отечественной и зарубежной экономической науки. Главной задачей на таких рынках является поиск баланса объема выпуска товара (оказания услуги) и его цены. Настоящее исследование посвящено анализу различных методов тарифообразования; определению соотношения понятий «тариф» и «цена».
Sonnenfleckenzeichnung Nr. 123.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.06.1996, 07:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Physical properties of EuPd2As2 single crystals
Creators: name: Anand, V. K.
name: Johnston, D. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The physical properties of self-flux grown EuPd2As2 single crystals have been investigated by magnetization M, magnetic susceptibility chi, specific heat Cp, and electrical resistivity rho measurements versus temperature T and magnetic field H. The crystal structure was determined by powder x-ray diffraction measurements, which confirmed the ThCr2Si2-type body-centered tetragonal structure (space group I4/mmm) reported previously. The rho(T) data indicate that state of EuPd2As2 is metallic. Long-range antiferromagnetic (AFM) ordering is apparent from the chi(T), Cp(T), and rho(T) measurements. For H \parallel c the chi(T) indicates two transitions at TN1 = 11.0 K and TN2 = 5.5 K, whereas for H \perp c only one transition is observed at TN1 = 11.0 K. Between TN1 and TN2 the anisotropic chi(T) data suggest a planar noncollinear AFM structure, whereas at T < TN2 the chi(T) and M(H,T) data suggest a spin reorientation transition in which equal numbers of spins cant in opposite directions out of the ab plane. We estimate the critical field at 2 K at which all Eu moments become aligned with the field to be about 22 T. The magnetic entropy at 25 K estimated from the Cp(T) measurements is about $11\%$ smaller than expected, possibly due to an inaccuracy in the lattice heat capacity contribution. An upturn in rho at T < TN1 suggests superzone energy gap formation below TN1. This behavior of rho(T < TN1) is not sensitive to applied magnetic fields up to H = 12 T.
description: 11 pages, 10 figures, 2 tables and 52 references; To appear in J. Phys.: Condens. Matter
title: An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
Creators: name: Kaya, Pelin
name: Schaffner-Reckinger, Elisabeth
name: Manoharan, Ganesh babu
name: Vukic, Vladimir
name: Kiriazis, Alexandros
name: Ledda, Mirko
name: VICARIO PÉREZ, ANA MARIA
name: Pavic, Karolina
name: Gaigneaux, Anthoula
name: Glaab, Enrico
name: Abankwa, Daniel
Publisher: name: LCSB
Year: 2023

description: The activity of inhibitors against the trafficking chaperone PDE6D (or PDE𝛿) in KRAS-mutant cancer cells has remained below expectations. We here developed new nanomolar PDE6D-inhibitors (PDE6Di) with improved on-target profiles, as assessed by a dedicated analysis in PDE6D-knockout MEFs and in an assay testing for the intracellular engagement of the PDE6D-related UNC119A. Our results demonstrate that a higher affinity to the hydrophobic pocket of PDE6D creates both solubility and off-target issues. In order to further improve the K-Ras selectivity of our highly soluble compound, Deltaflexin3, we combined it with Sildenafil. Sildenafil stimulates Ser181-phophorylation and thus loss of PDE6D-affinity of K-Ras. Thus, the combination robustly reduces Ras-signaling, and synergistically inhibits the proliferation of cancer cells and ex vivo tumor growth. Our work provides the currently most selective and highly soluble PDE6Di and suggests synergistic combinations to focus the inhibition on K-Ras.
Estimation of Vegetative Growth in Strawberry Plants Using Mobile LiDAR Laser Scanner
Creators: name: Saha, Kowshik Kumar
name: Tsoulias, Nikos
name: Weltzien, Cornelia
name: Zude-Sasse, Manuela
Publisher: name: Basel : MDPI
Year: 2022
Subjects: subject: Canopy volume
subject: Fragaria × ananassa
subject: Non-destructive
subject: Point cloud
subject: Volume profile
subject: 630
subject: 640

description: Monitoring of plant vegetative growth can provide the basis for precise crop manage-ment. In this study, a 2D light detection and ranging (LiDAR) laser scanner, mounted on a linear conveyor, was used to acquire multi-temporal three-dimensional (3D) data from strawberry plants (‘Honeoye’ and ‘Malling Centenary’) 14–77 days after planting (DAP). Canopy geometrical variables, i.e., points per plant, height, ground projected area, and canopy volume profile, were extracted from 3D point cloud. The manually measured leaf area exhibited a linear relationship with LiDAR-derived parameters (R2 = 0.98, 0.90, 0.93, and 0.96 with number of points per plant, volume, height, and projected canopy area, respectively). However, the measuring uncertainty was high in the dense canopies. Particularly, the canopy volume estimation was adapted to the plant habitus to remove gaps and empty spaces in the canopy point cloud. The parametric values for maximum point to point distance (Dmax) = 0.15 cm and slice height (S) = 0.10 cm resulted in R2 = 0.80 and RMSPE = 26.93% for strawberry plant volume estimation considering actual volume measured by water displacement. The vertical volume profiling provided growth data for cultivars ‘Honeoye’ and ‘Malling Centenary’ being 51.36 cm3 at 77 DAP and 42.18 cm3 at 70 DAP, respectively. The results contribute an approach for estimating plant geometrical features and particularly strawberry canopy volume profile based on LiDAR point cloud for tracking plant growth.
ОРГАНИЗАЦИЯ И ПРОДВИЖЕНИЕ КНИЖНОЙ ТОРГОВЛИ В УСЛОВИЯХ ЦИФРОВИЗАЦИИ
Creators: name: ИЗОТОВА А.Г.
name: ЛИТВИНОВА Н.А.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: КНИЖНАЯ ТОРГОВЛЯ
ЦИФРОВИЗАЦИЯ
РЫНОК КНИГОТОРГОВЛИ
МАРКЕТПЛЕЙС
МАРКЕТИНГ
ИНТЕРНЕТ-МАГАЗИН
BOOK TRADE
DIGITALIZATION
BOOKSELLING MARKET
MARKETPLACE
MARKETING
ONLINE STORE

description: В данной статье рассматривается организация книжной торговли в сети Интернет и способы ее продвижения. В результате проведенного анализа данной отрасли выявлена тенденция стабильного роста продаж печатной книги в Интернет-канале, роста продаж электронных и аудиокниг. Сделан вывод о значимости интернет-канала, как одного из перспективных направлений сбытовой политики книжной торговли, в частности маркетплейсов - как крупнейших торговых площадок. В работе даны рекомендации по продвижению интернет-магазина книжной продукции.
Sonnenfleckenzeichnung Nr. 76.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.04.1996, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
БИЗНЕС В УСЛОВИЯХ ПАНДЕМИИ: ОРГАНИЗАЦИЯ УДАЛЕННОЙ РАБОТЫ И ОЦЕНКА ЭФФЕКТИВНОСТИ «УДАЛЕННОГО» УПРАВЛЕНИЯ
Creators: name: ПИВЕНЬ И.Г.
name: ЛИТВИНОВА А.С.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: УПРАВЛЕНИЕ
ОЦЕНКА ЭФФЕКТИВНОСТИ
УДАЛЕННАЯ РАБОТА
ГОСУДАРСТВЕННО-ЧАСТНОЕ ПАРТНЕРСТВО
РИСК-МЕНЕДЖМЕНТ
MANAGEMENT
PERFORMANCE EVALUATION
REMOTE WORK
PUBLIC-PRIVATE PARTNERSHIP
RISK MANAGEMENT

description: В статье рассмотрены и определены основные проблемы организации удаленной работы в период пандемии. Выделены положительные и отрицательные аспекты удаленной работы. Определены риски управления и необходимость формирования новой корпоративной культуры. Определена необходимость изменения подходов к оценке эффективности управления бизнес-структурами в новых условиях. Выделены особенности оценки эффективности управления в новых условиях бизнес-структурами, которые являются участниками государственно-частного партнерства.
Sonnenfleckenzeichnung Nr. 94.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.04.1996, 13:15, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Additional file 8 of Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells
Creators: name: Semina, Svetlana E.
name: Pal, Purab
name: Kansara, Nidhi S.
name: Huggins, Rosemary J.
name: Alarid, Elaine T.
name: Greene, Geoffrey L.
name: Frasor, Jonna
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 8: Supplemental Table 7 showing results of Functional Enrichment Analysis of NFκB gene signatures in integrated LTED (GSE122743) and 4OHT-treated MCF-7 cell populations.
ПЯТЬ СПОСОБОВ ПОВЫШЕНИЯ МОТИВАЦИИ СОТРУДНИКОВ К ПРОВЕДЕНИЮ СТРАТЕГИЧЕСКОГО АНАЛИЗА
Creators: name: ЧУЛАНОВА Д.Д.
name: ЛИФШИЦ А.С.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: МОТИВАЦИЯ
СТРАТЕГИЧЕСКИЙ АНАЛИЗ
ЭФФЕКТИВНОСТЬ
ИНСТРУМЕНТАЛЬНЫЙ ТИП МОТИВАЦИИ
ХОЗЯЙСКИЙ ТИП МОТИВАЦИИ
ПРОФЕССИОНАЛЬНЫЙ ТИП МОТИВАЦИИ
ПАТРИОТИЧЕСКИЙ ТИП МОТИВАЦИИ
MOTIVATION
STRATEGIC ANALYSIS
EFFICIENCY
INSTRUMENTAL TYPE OF MOTIVATION
MASTER'S TYPE OF MOTIVATION
PROFESSIONAL TYPE OF MOTIVATION
PATRIOTIC TYPE OF MOTIVATION

description: В статье разработаны и предложены 5 эффективных способов повышения мотивации сотрудников к проведению стратегического анализа. При разработке данных способов учитываются основные типы мотивации по классификации В.И. Герчикова. Комплекс способов усиления мотивации сотрудников к проведению квалифицированного и добросовестного стратегического анализа позволяет сочетать инициативность и сознательную дисциплину внутренних аналитиков на предприятии.
Sonnenfleckenzeichnung Nr. 230.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.09.1996, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 147.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.06.1996, 07:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
ОСОБЕННОСТИ ИНСТРУМЕНТОВ МАРКЕТИНГА ПЕРСОНАЛА В СИСТЕМЕ ГОСУДАРСТВЕННОЙ СЛУЖБЫ
Creators: name: ХУАЖЕВА Б.Р.
name: ЛОБАНОВА В.В.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ГОСУДАРСТВЕННАЯ СЛУЖБА
МАРКЕТИНГ ПЕРСОНАЛА
КОМПЛЕКС МАРКЕТИНГА
ИНСТРУМЕНТЫ МАРКЕТИНГА ПЕРСОНАЛА
PUBLIC SERVICE
STAFF MARKETING
COMPLEX MARKETING
PERSONNEL MARKETING TOOLS

description: В статье рассматривается понятие маркетинга персонала и целесообразность применения данной концепции в государственном и муниципальном управлении. Выделены особенности управления персоналом в ГМУ, которые влияют на элементы комплекса маркетинга органов государственной власти. Описываются преимущества применения маркетингового подхода в формировании кадрового состава государственной службы.
Sonnenfleckenzeichnung Nr. 20.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.02.1996, 13:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
A systematic review of disease prevalence, health-related quality of life, and economic outcomes associated with Friedreich’s Ataxia
Creators: name: Buesch, Katharina
name: Zhang, Rongrong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Friedreich ataxia (FA) is a rare, inherited neuromuscular disease characterized by an early onset and progressive limb and gait ataxia. Currently, there are no approved treatments for FA. It is important to understand the burden of FA, including its extent and the most salient elements. The objective of this study is therefore to systematically review the literature regarding the aspects of prevalence, health-related quality of life (HRQoL), and economic outcomes that are associated with FA, and to subsequently identify relevant knowledge gaps. Three systematic literature reviews were conducted to assess publications regarding FA prevalence, HRQoL, and economic outcomes. Search strategies were implemented in MEDLINE (Ovid) and EMBASE databases; study selection and quality assessment were conducted using current best practices. For each review, study characteristics and findings were summarized. A total of 36 studies were included. Review of prevalence studies (n = 22) indicated variation in the number of cases by region, and many regions were not represented at all. Regarding HRQoL (n = 12 studies), physical domains were consistently impacted, although findings regarding other domains and overall HRQoL were less clear. Cost studies (n = 2) encompassed 4 regions and revealed that costs related to the provision of care, including non-medical direct costs and indirect costs, accounted for the majority of FA-related costs. Findings from this systematic review revealed several knowledge gaps that would preclude the conduct of a robust assessment of the benefits and outcomes associated with a disease-modifying FA therapy. Additional understanding regarding patient and caregiver HRQoL and costs is required.
Sonnenfleckenzeichnung Nr. 186.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.08.1996, 10:00, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1996

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
A coding problem for pairs of subsets
Creators: name: Bollobas, Bela
name: Furedi, Zoltan
name: Kantor, Ida
name: Katona, G. O. H.
name: Leader, Imre
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05B40, 94B60

description: Let $X$ be an $n$--element finite set, $0
description: 11 pages (minor changes, and new citations added)
Extemporaneous combination therapy with nebivolol/zofenopril in hypertensive patients: usage in Italy
Creators: name: Volpe, Massimo
name: Pegoraro, Valeria
name: Peduto, Ilaria
name: Heiman, Franca
name: Meto, Suada
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Clinically describing hypertensive patients initiating nebivolol/zofenopril extemporaneous combination (NZ-EXC) and estimating the number of patients currently receiving NZ-EXC and of those potentially eligible for the fixed-dose combination of the two molecules (NZ-FDC) in Italy. This retrospective observational study used data from IQVIA Italian Longitudinal Patient Database (LPD). Adult hypertensive patients firstly prescribed NZ-EXC between 1 July 2011 and 30 June 2020 were identified and their demographic and clinical characteristics were extracted. Treatment adherence was evaluated as proportion of days covered (PDC) and classified as low (PDC <40%), intermediate (PDC ≥40% and <80%) or high (PDC ≥80%). Two additional cohorts were identified in 2019 to provide the national-level yearly estimates of patients prescribed NZ-EXC and of patients eligible for NZ-FDC. In total 1745 patients were prescribed NZ-EXC: 60% were women; mean age was 65 years. The most frequent comorbidities were dyslipidemia (19.0%), diabetes (15.5%) and thyroid diseases (13.1%); the most common co-prescribed treatments were antithrombotics (29.1%), lipid-lowering agents (28.8%), nonsteroidal anti-inflammatory drugs (26.1%) and antihyperglycemic agents (13.5%). Mean PDC was 39%, and 57% of the patients had a PDC < 40%. The yearly estimate of patients prescribed NZ-EXC in 2019 was 59,000, while potential users of NZ-FDC were estimated to be 29,000. NZ-EXC in hypertensive patients is a common practice in Italy and the development of a NZ-FDC can be a viable treatment option for hypertensive patients who are already receiving nebivolol and zofenopril through the concomitant assumption of two distinct pills. As supported by scientific literature, FDCs of antihypertensive drugs could simplify treatment, improve adherence and potentially reduce health-care costs as related to a better control of blood pressure.