cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
"Césarine Dietrich" de George Sand: Edition critique
Creators: name: Richardson, Nicole
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Literature, Romance.

description: Depuis les années cinquante de nombreux ouvrages de George Sand ont fait l'objet d'éditions critiques. Dans la plupart des cas, la recherche s'est attachée aux romans de la première manière comme Lelia et Indiana, entre autres. Pendant les années soixante-dix s'effectue un retournement de situation. Les romans de la maturité de Sand attirent de plus en plus l'attention des éditeurs. Néanmoins, ses tout derniers romans n'ont pas fait l'objet d'éditions critiques au sens rigoureux du terme. Dans cette partie négligée de la production romanesque de George Sand figure Césarine Dietrich. Rédigé en 1870, ce roman, mentionne incidemment dans certains ouvrages, a été très peu étudié. Il nous a paru qu'il était temps de le faire connaître et de le rendre enfin accessible aux lecteurs.
Supplementary document for Observation of rogue events in non-Markovian light - 4662763.pdf
Creators: name: Frostig, Hadas
name: de Lima, Itamar Silva
name: Fischer, Robert
name: Sheinfux, Hanan Herzig
name: Silberberg, Yaron
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplementary information
Efficiency of quantum controlled non-Markovian thermalization
Creators: name: Mukherjee, V.
name: Giovannetti, V.
name: Fazio, R.
name: Huelga, Susana F.
name: Calarco, T.
name: Montangero, S.
Publisher: name: Universität Ulm
Year: 2015
Subjects: subject: optimal control of quantum systems
subject: open quantum systems
subject: non-Markovian dynamics
subject: quantum speed limit
subject: DDC 530 / Physics
subject: Quantum Systems
subject: Quantenmechanisches System

description: Abstract We study optimal control strategies to optimize the relaxation rate towards the fixed point of a quantum system in the presence of a non-Markovian (NM) dissipative bath. Contrary to naive expectations that suggest that memory effects might be exploited to improve optimal control effectiveness, NM effects influence the optimal strategy in a non trivial way: we present a necessary condition to be satisfied so that the effectiveness of optimal control is enhanced by NM subject to suitable unitary controls. For illustration, we specialize our findings for the case of the dynamics of single qubit amplitude damping channels. The optimal control strategy presented here can be used to implement optimal cooling processes in quantum technologies and may have implications in quantum thermodynamics when assessing the efficiency of thermal micro-machines.
Assisted reproductive medicine: Systematic reviews and randomized controlled trials
Creators: name: Kashyap, Sonya
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Health Sciences, Obstetrics and Gynecology.
subject: Health Sciences, Public Health.

description: The objective for this thesis was to propose a question in the area of reproductive medicine that could be addressed by a clinical trial. In preparation for such a trial we conducted a systematic review of the topic. Our first question was whether metformin is of benefit compared to clomiphene citrate for ovulation induction and achievement of pregnancy in women with polycystic ovarian syndrome (PCOS). We conducted a systematic review (SR) and meta-analysis of the subject before designing and implementing a randomized controlled trial (RCT). The RCT was terminated for recruitment issues. Our PCOS SR led us to develop a novel ovarian stimulation protocol for poor responders. We used the lessons learned from our failed RCT and another systematic review to design and conduct a feasibility randomized controlled trial on the use of aromatase inhibitors to improve pregnancy outcomes for in-vitro fertilization in poor responders. We successfully completed the pilot study and found a trend towards increased clinical pregnancy rates for patients who received the study versus the standard protocol. The pilot study provides recommendations for the definitive trial.
Electrodeposition of Metallic Molybdenum and its Alloys : A Review
Creators: name: Hasan, Siti Nur
name: Xu, Min
name: Asselin, Edouard
Publisher: name: Taylor & Francis
Year: 2021

description: Aqueous electrodeposition may represent a more economical and reliable technique to fabricate Mo coatings than the alternatives (electrodeposition from fused-salt baths and other available methods). However, studies on the aqueous electrodeposition of pure metallic Mo are rather limited due to its oxophilic nature, catalytic behaviour for the hydrogen evolution reaction and high tendency for polymerisation, especially in acidic media. To date, researchers have tended to focus on the aqueous electrodeposition of Mo alloys. These alloys usually contain <51% Mo. The factors that influence the quality of Mo deposits and the difficulties in the electrodeposition process are reviewed here. This review not only presents a survey of existing literature on the electrodeposition of metallic Mo coatings but also provides a basis for any future exploration.
title: Improving mental health in high school students shortly before their final exams — a pilot study of a stress management intervention
Creators: name: Kortsch, Timo
name: Wegener, Nico
name: Schwake, Manon Elisa
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: stress
subject: stress management program
subject: students
subject: intervention study
subject: study demands resources framework
subject: burnout
subject: wellbeing
subject: COVID-19 pandemic
classificationCode: 150
subject: Psychologie

description: Stress - exacerbated by the COVID-19 pandemic - has become a major problem for students. Students who are about to graduate, are particularly affected, as they experience significant pressure from their final exams while simultaneously facing far-reaching decisions about their future. Stress management interventions can therefore be a valuable way to foster the development of more effective coping strategies. This study utilized a pre-post follow-up design to examine the effectiveness of the 2 days “Simply Less Stress” intervention - a structured program based on the Demands-Resources framework that encourages students to reflect on their individual stress emergence and equips them with practical stress management strategies - as a large group training in a group of high school graduates (N = 34). In addition, quasi-experimental effects on efficacy were examined in students who were undergoing parallel psychological supervision (or not). The results showed that the intervention significantly (p < 0.05) reduced burnout symptoms (dimension reduced feeling of efficacy: η2partial = 0.523) and increased overall study engagement (η2partial = 0.606). The exploratory analyses revealed that students currently receiving psychological support also benefited from the course, experiencing a significant increase in wellbeing. The results were supported by qualitative data from the questionnaires. This pilot study contributes to existing literature by providing preliminary evidence that a stress management intervention can achieve positive outcomes for students with and without parallel psychological support. The findings of this study emphasize the importance of implementing effective interventions, especially during particularly stressful episodes, to address stress among high school students and foster their wellbeing.
Moderated online social networking for young people who experience suicidal ideation: Ethics, acceptability, and potential clinical effectiveness
Creators: name: Bailey, Eleanor Claire Duffell
Publisher: name: Swinburne
Year: 2024

description: Suicide is leading cause of death in young people. Online interventions incorporating peer-to-peer social networking may be a potentially efficacious support for young people who experience suicidal thoughts and behaviours. However, due in part to feasibility and concerns, this had not been tested. The current thesis aimed to examine the potential for Internet-based interventions incorporating peer-to-peer social networking to support young people who experience suicidal ideation, and to explore the ethical and practical challenges associated with this research area. Findings pave the way for the development and evaluation of potentially helpful interventions for this vulnerable population.
Fractal analysis of myoelectric signals
Creators: name: Talebinejad, Mehran
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: In this thesis, we study fractal behavior of myoelectric signals (MESs). Mathematics and definitions behind fractal behavior is presented. Different methods of estimating the fractal dimension are discussed, including time domain-based methods (i.e. Katz method, Box-Counting method) and spectrum based methods (i.e. Power Spectrum Slope Method (PSSM) and General Power Spectrum Method (GPSM)). The GPSM is introduced in context of MESs for the first time. Using simulated MESs effects of its parameters (i.e. number of active motor units (MUs), firing rate and depth of active MUs) on estimated fractal dimension (eFD) and estimated fractal indicators (eFI) are analyzed. Spectrum based methods demonstrate characteristics that suggest superiority in discerning force effects (i.e. number of active MUs and firing rate) and geometric effects (i.e. depth of active MUs). Fractal behavior of MESs during Isometric Constant Force Contractions (ICFC) at different force and joint angles are analyzed. Results of the spectrum based methods suggest that they could possibly be used to estimate the joint angle independent of force. Fractal behavior of MESs during Isometric Voluntary Contractions (IVC) at different force and joint angles are analyzed as well. Results, although highly variable, remain consistent with the simulated results.
title: Measurement of Oro-Cecal Transit Time in LPS-Treated Pigs Fed High and Low Fiber Diets Using the Lactose-13C-Ureide Test in Breath and Saliva Samples
Creators: name: Cavalleri, Mariagrazia
name: Sciascia, Quentin L.
name: Görs, Solvig
name: Vernunft, Andreas
name: Reyer, Henry
name: Wimmers, Klaus
name: Zentek, Jürgen
name: Kluess, Jeannette
name: Dänicke, Sven
name: Metges, Cornelia C.
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: oro-cecal transit time
subject: dietary fiber
subject: lipopolysaccharide
subject: lactose-13C-ureide
subject: gut
subject: pig
classificationCode: 630
subject: Landwirtschaft und verwandte Bereiche

description: The lactose-13C-ureide (L13CU) test, used in humans to measure oro-cecal transit time (OCTT) in breath CO2, was assessed for its suitability in pigs as a noninvasive alternative to intestinal cannulation. The OCTT was determined with the L13CU test in breath and saliva samples when pigs were fed low or high dietary fiber (DF) (low fiber, 2.8% DF; high fiber 6.5% DF) diets, and 24 h after an i.m. injection with either lipopolysaccharide (LPS) or NaCl. The OCTT measured in breath was longer in LF-LPS than in LF-NaCl and HF-LPS groups (3.4 vs 2.9 h; p < 0.05). Additionally, LPS prolonged the OCTT of pigs, and DF prevented this effect. 90 % of OCTT estimates measured in saliva and breath CO2 did not differ. We conclude that the L13CU breath test is useful for determining OCTT in pigs; saliva is generally suitable as a sample matrix for OCTT, but its use requires further validation.
Supplementary document for Airy-beam Tomographic Microscopy - 4663449.pdf
Creators: name: Jia, Shu
name: Wang, Jian
name: Hua, Xuanwen
name: Guo, Changliang
name: Liu, Wenhao
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement
title: Mechanisms and functions of lysosomal lipid homeostasis
Creators: name: Ebner, Michael
name: Fröhlich, Florian
name: Haucke, Volker
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: lysosomes
subject: lipids
subject: phosphoinositides
subject: membrane homeostasis
subject: contact sites
subject: signalling
classificationCode: 570
subject: Biowissenschaften; Biologie

description: Lysosomes are the central degradative organelle of mammalian cells and have emerged as major intersections of cellular metabolite flux. Macromolecules derived from dietary and intracellular sources are delivered to the acidic lysosomal lumen where they are subjected to degradation by acid hydrolases. Lipids derived from lipoproteins, autophagy cargo, or autophagosomal membranes themselves constitute major lysosomal substrates. Dysregulation of lysosomal lipid processing, defective export of lipid catabolites, and lysosomal membrane permeabilization underly diseases ranging from neurodegeneration to metabolic syndromes and lysosomal storage disorders. Mammalian cells are equipped with sophisticated homeostatic control mechanisms that protect the lysosomal limiting membrane from excessive damage, prevent the spillage of luminal hydrolases into the cytoplasm, and preserve the lysosomal membrane composition in the face of constant fusion with heterotypic organelles such as endosomes and autophagosomes. In this review we discuss the molecular mechanisms that govern lysosomal lipid homeostasis and, thereby, lysosome function in health and disease.
title: What issues need to be addressed in the RED II draft to ensure environmental integrity and net climate benefit of bioenergy use
title: What issues need to be addressed in the RED II draft to ensure environmental integrity and net climate benefit of bioenergy use
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2018
Subjects: subject: Grünwäsche
subject: LULUCF [Kyoto-Protokoll]
subject: Bioenergie
subject: Schadstoffemission
subject: Greenwashing
subject: LULUCF
subject: bioenergy
subject: GHG emission
subject: Klima | Energie
subject: Climate | Energy

description: With this scientific opinion paper, we aim to raise awareness for some issues leading to insufficient GHG savings and potentially causing a gap between two climate and energy legislative frameworks of the European Union: the recast of the Renewable Energy Directive (RED II) and the Land Use, Land Use Change and Forestry Regulation (LULUCF Regulation). Quelle: https://www.umweltbundesamt.de
description: With this scientific opinion paper, we aim to raise awareness for some issues leading to insufficient GHG savings and potentially causing a gap between two climate and energy legislative frameworks of the European Union: the recast of the Renewable Energy Directive (RED II) and the Land Use, Land Use Change and Forestry Regulation (⁠LULUCF⁠ Regulation).
Influence of aberrations and roughness on the chromatic confocal signal based on experiments and wave-optical modeling
Creators: name: Claus, Daniel
name: Nizami, Moaaz Rauf
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Optical metrology
subject: chromatic confocal microscopy
subject: wave optical modelling
subject: DDC 620 / Engineering & allied operations
subject: Color
subject: Numerische Apertur

description: Abstract This paper addresses the effect and influence of wave optical aberrations and surface roughness on the chromatic confocal signal and resulting measurement errors. Two possible approaches exist for implementing chromatic confocal imaging based on either refraction or diffraction. Both concepts are compared and an expression for the expected chromatic longitudinal aberrations when using a diffractive optical element is derived. Since most chromatic confocal sensors are point sensors, the discussion on wave-optical aberrations is focused on spherical aberrations. Against common belief, the effect of spherical aberrations cannot be eliminated in the calibration process using for instance a piezo mounted mirror. It will be shown in the following that even a diffraction limited system with peak to valley spherical aberration smaller than 0.25 wavelength suffers from measurement errors. Experimental results will be shown to highlight this important issue. In order to develop a deeper understanding of the underlying physics, a wave-optical simulation environment has been realized. This wave-optical model furthermore enables the investigation of the influence of roughness. Herethereto the correct choice of numerical aperture when investigating a rough surface is based on a heuristic approach. Using the wave-optical simulations an explanation for the increased noise when employing a low numerical aperture to examine rough surfaces will be derived. Furthermore, a formula is presented to support the selection of the correct numerical aperture with regards to the roughness parameters of the surface under investigation.
Impact of Multiple Factors on the Degree of Tinnitus Distress
Creators: name: Brueggemann, Petra
name: Szczepek, Agnieszka J.
name: Rose, Matthias
name: McKenna, Laurence
name: Olze, Heidi
name: Mazurek, Birgit
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: the grade of tinnitus-related distress
subject: the psychological distress
subject: physical or psychological discomfort
subject: social parameters
subject: multi-level analyses
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective: The primary cause of subjective tinnitus is a dysfunction of the auditory system; however, the degree of distress tinnitus causes depends largely on the psychological status of the patient. Our goal was to attempt to associate the grade of tinnitus-related distress with the psychological distress, physical, or psychological discomfort patients experienced, as well as potentially relevant social parameters, through a simultaneous analysis of these factors. Methods: We determined the level of tinnitus-related distress in 531 tinnitus patients using the German version of the tinnitus questionnaire (TQ). In addition, we used the Perceived Stress Questionnaire (PSQ); General Depression Scale Allgemeine Depression Skala (ADS), Berlin Mood Questionnaire (BSF); somatic symptoms inventory (BI), and SF-8 health survey as well as general information collected through a medical history. Results: The TQ score significantly correlated with a score obtained using PSQ, ADS, BSF, BI, and SF-8 alongside psychosocial factors such as age, gender, and marital status. The level of hearing loss and the auditory properties of the specific tinnitus combined with perceived stress and the degree of depressive mood and somatic discomfort of a patient were identified as medium-strong predictors of chronic tinnitus. Social factors such as gender, age, or marital status also had an impact on the degree of tinnitus distress. The results that were obtained were implemented in a specific cortical distress network model. Conclusions: Using a large representative sample of patients with chronic tinnitus permitted a simultaneous statistical measurement of psychometric and audiological parameters in predicting tinnitus distress. We demonstrate that single factors can be distinguished in a manner that explains their causative association and influence on the induction of tinnitus-related distress.
title: Babylonian Astronomy: Editing and Interpreting an Ancient Science
Creators: name: Ossendrijver, Mathieu
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: astral science
subject: babylonian astronomy
subject: Babylonian astral science
subject: astronomical tablets
classificationCode: 935
subject: Geschichte Mesopotamiens und der iranischen Hochebene bis 637

description: The year 1881 marks the birth of Babylonian astronomy as a modern area of scholarship with the first publication about this topic. From the outset, its scholarly practices were based on a variety of methods rooted in Assyriology, astronomy, mathematics and the history of science. In this chapter, the editing practices that were applied to Babylonian astronomical texts and their relationship to research methods in the abovementioned disciplines are traced through the works of the main scholars who were active in the field of Babylonian astronomy between 1881 and 1955. In this period, two phases can be distinguished: a pioneering phase (1881–1935) in which mainly individual tablets were edited while editing practices remained fluid, and a subsequent phase characterized by the appearance of standard editions of complete and coherent corpora of texts. In both phases, the translations and interpretations were strongly shaped by modern mathematics and astronomy.
A new concept for the ecotoxicological assessment of plastics under consideration of aging processes
Creators: name: Kittner, Maria
name: Isernhinke, Lisa
name: Altmann, Korinna
name: Lukas, Marcus
name: Braun, Ulrike
Publisher: name: My University
Year: 2023
Subjects: Ökotoxikologie
Mikroplastikpartikel
Polystyrol
Verwitterung

description: Microplastics are widely distributed in aquatic and terrestrial environments, but up tonow less is known about (eco)toxicological impacts under realistic conditions. Researchso far has focused mainly on impacts on organisms by fresh, single-origin plasticfragments or beads. However, plastics found in the environment are complex incomposition, this means different polymer types and sources, with and withoutadditives and in all stages of age, and therefore, in a more or less advanced stage ofdegradation. For oxidized degradation products that might be released from plasticmaterials during aging, there is a lack of information on potentially adverse effects onaquatic biota. The latter is of particular interest as oxidized degradation products mightbecome more water soluble due to higher polarity and are more bioavailable, therefore.The present study focused on plastic leachates of polystyrene (PS) and polylactic acid(PLA), which were derived from alternating stress by hydrolysis and ultraviolet (UV)radiation-representing a realistic scenario in the environment. Test specimens of PS,PLA, or a PLA/PS layer (each 50%) were alternately exposed to UV radiation for 5 daysfollowed by hydrolysis for 2 days, for several weeks alternating. Ecotoxicological effectsof the storage water (artificial freshwater) of the test specimens and additionally, in asecond experimental setup, the effects of five potential polymer degradation productswere detected by 72 h algae growth inhibition tests withDesmodesmus subspicatus.Results clearly indicate inhibitory effects on algae growth by contaminants in thestorage water of stressed plastics with increasing growth inhibition of proceedinghydrolysis and UV stress times. Different polymers caused variable inhibitions of algaegrowth with stronger inhibitions by PS and less effects by PLA and the mixed layer ofboth. Moreover, not microplastic particles but the resulting dissolved degradationproducts after aging caused theecotoxicological effectsââą Ìwith strong effects by theoxidized degradation products. The existing data highlight the relevance of plastic agingas a framework for microplastic ecotoxicity evaluation and allow a proof of concept. © 2023 The Authors.
Conductivity and ion-pair formation in acetone solution as a function of pressure and temperature.
Creators: name: Adams, W. A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1967
Subjects: subject: Chemistry, Physical.

description: The equivalent conductivities of tetramethylammonium iodide, tetraethylammonium iodide, and tetra-n-propylammonium iodide in acetone solution were determined at temperatures of 25° to 55°C, and at pressures from atmospheric to 1.1 kbar. The results have been analysed by the Shedlovsky method. The limiting equivalent conductivities have been interpreted in terms of activated complex theory; the energies of activation for conductivity at constant pressure and at constant volume, and the volumes of activation for conductivity, were calculated, The hole free-volume theory of liquids has been discussed for different solvent systems and found to give a satisfactory explanation for the observed pressure and temperature coefficients of conductivity, viscosity, and self-diffusion in several solvents. The magnitude of the limiting ionic equivalent conductivity has been shown to depend in a critical way on the ionic radius and on the relative strengths of the ion-solvent and the solvent-solvent interactions. The ion-pair dissociation constants determined from the Shedlovsky analysis were used to calculate the enthalpy, the internal energy at constant volume, the entropy, the volume, and the Gibbs free energy of dissociation. The sign and magnitude of these parameters over the range of conditions of temperature and pressure investigated indicated that the free ions in acetone solution are extensively solvated and that, depending on the conditions, solvent-shared or solvent-separated ion pairs are formed. The compressibility of acetone has been redetermined at temperatures of 25° to 55°C, and at pressures from atmospheric to 1.1 kbar. The results have been fitted to the Tait equation, and values of (deltaP/deltaT) V and of the internal pressure have been calculated. The heat capacity at constant volume has also been deduced as a function of pressure and temperature. The variation of these a-rid other derived quantities has been shown to lead to conclusions about structural changes in the liquid.
Double-flow focused liquid injector for efficient serial femtosecond crystallography
Creators: name: Oberthuer, Dominik
name: Knoska, Juraj
name: Wiedorn, Max O.
name: Beyerlein, Kenneth R.
name: Bushnell, David A.
name: Kovaleva, Elena G. [U.V.M.]
name: Szczepek, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Fluid dynamics
subject: Nanocrystallography
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Serial femtosecond crystallography requires reliable and efficient delivery of fresh crystals across the beam of an X-ray free-electron laser over the course of an experiment. We introduce a double-flow focusing nozzle to meet this challenge, with significantly reduced sample consumption, while improving jet stability over previous generations of nozzles. We demonstrate its use to determine the first room-temperature structure of RNA polymerase II at high resolution, revealing new structural details. Moreover, the double flow- focusing nozzles were successfully tested with three other protein samples and the first room temperature structure of an extradiol ring-cleaving dioxygenase was solved by utilizing the improved operation and characteristics of these devices.
Modellierung von komplexen Systemen mit AutomationML
Creators: name: Hirner, Martin
name: Neff, Felix
name: Thiel, Yannick
Publisher: name: Technische Hochschule Ulm
Year: 2023
Subjects: subject: DDC 004 / Data processing & computer science
subject: DDC 330 / Economics
subject: DDC 600 / Technology (Applied sciences)
subject: AutomationML
subject: Fischertechnik
subject: Logistiksystem
subject: Produktionssystem
subject: Datenmodellierung

description: Die vorliegende Masterprojektarbeit befasst sich mit der Modellierung komplexer Systeme mit AutomationML (AML), einer umfassenden, XML-basierten, objektorientierten Datenmodellierungssprache. Diese Modellierungssprache ermöglicht die Modellierung, Speicherung und den Austausch von technischen Modellen, was im Zuge dieser Projektarbeit am didaktischen automatischen Kleinteilelager (AKL) und dem fischertechnik Industrie 4.0 Demonstrator des Instituts für Betriebsorganisation und Logistik (IBL) der Technischen Hochschule Ulm (THU) dargestellt wird.
title: Tutorial de ecografía escrotal
Creators: name: Navarro-Sanchis, Eugenio
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Genital / Reproductive system male
subject: Ultrasound

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1.
Dar a conocer una herramienta multimedia realizada con PowerPoint®,
cuyo contenido incluye la técnica de la ecografía escrotal,
la anatomía y patología. 2.
Mostrar la utilidad del tutorial en la formación de residentes en ecografía...
Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans
Creators: name: Houtepen, Lotte C.
name: Vinkers, Christiaan H.
name: Carrillo-Roa, Tania
name: Hiemstra, Marieke
name: Lier, Pol A. Van
name: Meeus, Wim
name: Branje, Susan
name: Heim, Christine M.
name: Nemeroff, Charles B.
name: Mill, Jonathan
name: Schalkwyk, Leonard C.
name: Creyghton, Menno P.
name: Kahn, Rene S.
name: Joels, Marian
name: Binder, Elisabeth B.
name: Boks, Marco P. M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Biological sciences
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular biology
subject: Neuroscience
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: DNA methylation likely plays a role in the regulation of human stress reactivity. Here we show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a locus in the Kit ligand gene (KITLG; cg27512205) showed the strongest association with cortisol stress reactivity (P=5.8 × 10−6). Replication was obtained in two independent samples using either blood (N=45, P=0.001) or buccal cells (N=255, P=0.004). KITLG methylation strongly mediates the relationship between childhood trauma and cortisol stress reactivity in the discovery sample (32% mediation). Its genomic location, a CpG island shore within an H3K27ac enhancer mark, and the correlation between methylation in the blood and prefrontal cortex provide further evidence that KITLG methylation is functionally relevant for the programming of stress reactivity in the human brain. Our results extend preclinical evidence for epigenetic regulation of stress reactivity to humans and provide leads to enhance our understanding of the neurobiological pathways underlying stress vulnerability.
Advanced Use of Recycled Plastic in Pavement Construction: Whole of Life Cycle Analysis
Creators: name: SALEHI, SAFOURA
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 401102
subject: Environmentally sustainable engineering
classificationCode: 401105
subject: Life cycle assessment and industrial ecology
classificationCode: 400502
subject: Civil geotechnical engineering

description: This thesis explores the potential of Recycled Plastic-Modified Asphalt (RPMA) as a sustainable alternative in pavement construction. It introduces a Life Cycle Assessment (LCA) framework to evaluate RPMA's environmental impact, focusing on its production phase and recycling processes. Additionally, machine learning models are employed to predict RPMA's performance, including viscoelastic properties and susceptibility to cracking and rutting under various conditions. The study highlights RPMA's environmental benefits, especially in reducing carbon emissions and resource depletion, and underscores the efficacy of machine learning in optimizing pavement design. Overall, the research offers valuable insights for promoting sustainable pavement engineering practices and informed decision-making in infrastructure development.
Systematic evaluation of isoform function in literature reports of alternative splicing
Creators: name: Bhuiyan, Shamsuddin A
name: Ly, Sophia
name: Phan, Minh
name: Huntington, Brandon
name: Hogan, Ellie
name: Liu, Chao C
name: Liu, James
name: Pavlidis, Paul
Publisher: name: BioMed Central
Year: 2018

description: Background: Although most genes in mammalian genomes have multiple isoforms, an ongoing debate is whether these isoforms are all functional as well as the extent to which they increase the functional repertoire of the genome. To ground this debate in data, it would be helpful to have a corpus of experimentally-verified cases of genes which have functionally distinct splice isoforms (FDSIs). Results: We established a curation framework for evaluating experimental evidence of FDSIs, and analyzed over 700 human and mouse genes, strongly biased towards genes that are prominent in the alternative splicing literature. Despite this bias, we found experimental evidence meeting the classical definition for functionally distinct isoforms for ~ 5% of the curated genes. If we relax our criteria for inclusion to include weaker forms of evidence, the fraction of genes with evidence of FDSIs remains low (~ 13%). We provide evidence that this picture will not change substantially with further curation and conclude there is a large gap between the presumed impact of splicing on gene function and the experimental evidence. Furthermore, many functionally distinct isoforms were not traceable to a specific isoform in Ensembl, a database that forms the basis for much computational research. Conclusions: We conclude that the claim that alternative splicing vastly increases the functional repertoire of the genome is an extrapolation from a limited number of empirically supported cases. We also conclude that more work is needed to integrate experimental evidence and genome annotation databases. Our work should help shape research around the role of splicing on gene function from presuming large general effects to acknowledging the need for stronger experimental evidence.
title: Heizen mit Holz
title: Heizen mit Holz
titleType: AlternativeTitle
Creators: name: Behnke, Anja
name: Kemper, Bernd-Michael
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Heizung
subject: Brennholz
subject: Ressourcenerhaltung
subject: Feuerungstechnik
subject: Bioenergieträger
subject: Kamin
subject: Kleinfeuerungsanlage
subject: Feuerung
subject: Holzkessel
subject: Heizen mit Holz
subject: Holzofen
subject: Kaminofen
subject: Öfen
subject: Einzelraumfeuerung
subject: Festbrennstoffkessel
subject: Feuerungsanlage
subject: Feinstaub aus Holzöfen
subject: Klima | Energie
subject: Luft

description: Die Verbrennung von Holz, gerade bei Scheitholz in kleinen Holzfeue-rungsanlagen ohne automatische Regelung, läuft nie vollständig ab und es entstehen neben gesundheitsgefährdenden Luftschadstoffen auch klima-schädliches Methan, Lachgasund Ruß. Sollte Holz dennoch in Kleinfeuerungsanlagen verbrannt werden, sollte dies möglichst emissionsarm, mit einem möglichst hohen Wirkungsgrad erfolgen. Voraussetzung ist, dass man gut aufbereitetes und getrocknetes Holz aus nachhaltiger regionaler Forstwirtschaft in einer modernen, effizienten und emissionsarmen Feuerstätte verbrennt. Diese Broschüre stellt umfangreiche Hintergrundinformationen zur energetischen Holznutzung bereit und gibt Ihnen Tipps, was Sie beim Umgang mit einer Holzheizung â€Ì im Fachausdruck: Kleinfeuerungsanlage - beachten müssen. Quelle: www.umweltbundesamt.de
description: Die Verbrennung von Holz, gerade bei Scheitholz in kleinen Holzfeue­rungsanlagen ohne automatische Regelung, läuft nie vollständig ab und es entstehen neben gesundheitsgefährdenden Luftschadstoffen auch klima­schädliches Methan, Lachgasund Ruß. Sollte Holz dennoch in Kleinfeuerungsanlagen verbrannt werden, sollte dies möglichst emissionsarm, mit einem möglichst hohen Wirkungsgrad erfolgen. Voraussetzung ist, dass man gut aufbereitetes und getrocknetes Holz aus nachhaltiger regionaler Forstwirtschaft in einer modernen, effizienten und emissionsarmen Feuerstätte verbrennt. Diese Broschüre stellt umfangreiche Hintergrundinformationen zur energetischen Holznutzung bereit und gibt Ihnen Tipps, was Sie beim Umgang mit einer Holzheizung – im Fachausdruck: Kleinfeuerungsanlage – beachten müssen.
Thermodynamik : Hauptsätze, reine Stoffe, Mischungen und Reaktionen
Creators: name: Kleiser, Georg
Publisher: name: Technische Hochschule Ulm
Year: 2021
Subjects: subject: DDC 600 / Technology (Applied sciences)
subject: DDC 620 / Engineering & allied operations
subject: Thermodynamik
subject: Energietechnik
subject: Wärmetechnik

description: Thermodynamik ist die Wissenschaft über Energiewandlungen. Da Energiewandlungsvorgänge bei den meisten technischen Vorgänge eine zentrale Rolle spielen, werden in vielen Ingenieursdisziplinen - mehr oder weniger tief - thermodynamische Kompetenzen vorausgesetzt. Themodynamische Kompetenzen erlauben den Ingenieuren, Systeme, Maschinen und Geräte hinsichtlich ihres Energieumsatzes auszulegen sowie Aussagen zur Energieeffizienz abzuleiten. Die hierfür erforderlichen Kenntnisse benötigen vor allem Ingenieure in der Energietechnik und der Verfahrenstechnik, da dort Prozesse mit besonders hohen Energieumsätzen zu gestalten sind. Sie sind jedoch auch ein zentraler Bestandteil ingenieurwissenschaftlicher Überlegungen im Maschinenbau, der Produktionstechnik, Gebäudetechnik, Fahrzeugtechnik, Medizintechnik, Elektrotechnik und vielen anderen Ingenieursdisziplinen. Dieses Buch behandelt zunächst die Grundlagen, wie Energiebilanzen aufzustellen und zu bewerten sind. Hierzu werden insbesondere der erste und der zweite Hauptsatz vorgestellt und zur Bilanzierung verschiedener Systemkategorien angewendet. Das Buch orientiert sich hierbei an der praktischen Anwendung für Ingenieure. Es beschränkt sich in der Regel auf einfache Modelle und Annahmen, wie sie in der tatsächlichen Ingenieurspraxis am häufigsten Anwendung finden. Komplexe Stoffmodelle sowie die physikalisch-chemischen Erklärungen der Ursachen für das Verhalten von Materie werden nur dann ausgeführt, wenn es zum Verständnis der technischen Prozesse wirklich notwendig ist.
title: Evaluación  con TC multicorte de las apófisis pterigoides tras cirugía ortognática (osteotomía  LeFort I)
Creators: name: Utrilla Contreras, Cristina
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: Head and neck

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1.
Evaluar las apófisis pterigoides mediante TC multicorte (TCMD) tras realizar osteotomía de LeFort I como procedimiento de cirugía ortognática. 2.
Valorar las discrepancias entre la percepción quirúrgica de integridad y los hallazgos de...
title: TC craneal  urgente  ... ¿ cuándo  ? y  ¿ por qué ?
Creators: name: Díez García, Luis Javier
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: Emergency

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
El propósito de está comunicación es doble : por una parte repasamos las indicaciones de TC craneal urgente ,
que recoge la literatura médica ( fig 1 ) ,
ilustrando las mismas con casos de nuestro archivo y por otra incluimos una serie de "...
title: Varicocele como presentación clínica inicial de neoplasias retroperitoneales.
Creators: name: Pérez Sánchez, Pablo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Evaluar en aquellos pacientes con presentación clínica inicial de varicocele,
la necesidad de completar el estudio con una técnica de imagen complementaria,
con la finalidad de descartar etiología abdominal (tumoraciones renales o...
Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival
Creators: name: Braunholz, Diana
name: Saki, Mohammad
name: Niehr, Franziska
name: Oeztuerk, Merve
name: Puertolas, Berta Borras
name: Konschak, Rober
name: Budach, Volker
name: Tinhofer, Ingeborg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In solid tumours millions of cells are shed into the blood circulation each day. Only a subset of these circulating tumour cells (CTCs) survive, many of them presumable because of their potential to form multi-cellular clusters also named spheroids. Tumour cells within these spheroids are protected from anoikis, which allows them to metastasize to distant organs or re-seed at the primary site. We used spheroid cultures of head and neck squamous cell carcinoma (HNSCC) cell lines as a model for such CTC clusters for determining the role of the epidermal growth factor receptor (EGFR) in cluster formation ability and cell survival after detachment from the extra-cellular matrix. The HNSCC cell lines FaDu, SCC-9 and UT-SCC-9 (UT-SCC-9P) as well as its cetuximab (CTX)-resistant sub-clone (UT-SCC-9R) were forced to grow in an anchorage- independent manner by coating culture dishes with the anti-adhesive polymer poly-2-hydroxyethylmethacrylate (poly-HEMA). The extent of apoptosis, clonogenic survival and EGFR signalling under such culture conditions was evaluated. The potential of spheroid formation in suspension culture was found to be positively correlated with the proliferation rate of HNSCC cell lines as well as their basal EGFR expression levels. CTX and gefitinib blocked, whereas the addition of EGFR ligands promoted anchorage-independent cell survival and spheroid formation. Increased spheroid formation and growth were associated with persistent activation of EGFR and its downstream signalling component (MAPK/ERK). Importantly, HNSCC cells derived from spheroid cultures retained their clonogenic potential in the absence of cell-matrix contact. Addition of CTX under these conditions strongly inhibited colony formation in CTX- sensitive cell lines but not their resistant subclones. Altogether, EGFR activation was identified as crucial factor for anchorage-independent survival of HNSCC cells. Targeting EGFR in CTC cluster formation might represent an attractive anti-metastatic treatment approach in HNSCC.
KiDS-450: Tomographic cross-correlation of galaxy shear with Planck lensing
Creators: name: Harnois-Déraps, Joachim
name: Tröster, Tilman
name: Chisari, Nora Elisa
name: Heymans, Catherine
name: van Waerbeke, Ludovic
name: Asgari, Marika
name: Bilicki, Maciej
name: Choi, Ami
name: Erben, Thomas
name: Hildebrandt, Hendrik
name: Hoekstra, Henk
name: Joudaki, Shahab
name: Kuijken, Konrad
name: Merten, Julian
name: Miller, Lance
name: Robertson, Naomi
name: Schneider, Peter
name: Viola, Massimo
Publisher: name: Swinburne
Year: 2024

description: We present the tomographic cross-correlation between galaxy lensing measured in the Kilo Degree Survey (KiDS-450) with overlapping lensing measurements of the cosmic microwave background (CMB), as detected by Planck 2015.We compare our joint probe measurement to the theoretical expectation for a flat Λ cold dark matter cosmology, assuming the best-fitting cosmological parameters from the KiDS-450 cosmic shear and Planck CMB analyses. We find that our results are consistent within 1s with the KiDS-450 cosmology, with an amplitude re-scaling parameter A KiDS = 0.86 ± 0.19. Adopting a Planck cosmology, we find our results are consistent within 2s, with A Planck = 0.68±0.15.We show that the agreement is improved in both cases when the contamination to the signal by intrinsic galaxy alignments is accounted for, increasing A by ~0.1. This is the first tomographic analysis of the galaxy lensing - CMB lensing cross-correlation signal, and is based on five photometric redshift bins. We use this measurement as an independent validation of the multiplicative shear calibration and of the calibrated source redshift distribution at high redshifts. We find that constraints on these two quantities are strongly correlated when obtained from this technique, which should therefore not be considered as a stand-alone competitive calibration tool.
title: Las diferentes caras de la aspergilosis pulmonar
Creators: name: Koren, Laura
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Infection
subject: CT
subject: Thorax

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar el espectro de los hallazgos radiológicos de la aspergilosis pulmonar y correlacionarlos con la respuesta inmune del paciente y las manifestaciones clínicas. Discutir brevemente los principales diagnósticos...
Supplementary document for Transparent electrode employing deep subwavelength monolithic high-contrast grating integrated with metal - 4665243.pdf
Creators: name: Czyszanowski, Tomasz
name: Sokół, Adam
name: Dems, Maciej
name: Wasiak, Michal
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement
Chronically ill patients' view of health, illness and the healing relationships in integrative medicine
Creators: name: Richard, Nathalie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Alternative Medicine.
subject: Health Sciences, Medicine and Surgery.

description: The increasing popularity of integrative medicine requires that we understand the meaning that patients attribute to their treatment experience. This project was a phenomenological study that sought to understand how nine chronically ill patients perceived their experience of living with illnesses and the treatment process at the integrative clinic. My findings reveal that their illnesses disrupted their life and were a threat to their self. An impetus combined with the influence of the social sphere led patients to join the clinic. The relationship with caregivers at the clinic was an important component of the treatment process and provided participants with the knowledge necessary to manage their illnesses. The positive interaction with caregivers enhanced patient empowerment and improved patient participation. Following treatments at the clinic, the majority of participants felt that their health had improved and that they had returned to their old self. Many had set future goals.
Supplementary document for Transparent electrode employing deep subwavelength monolithic high-contrast grating integrated with metal - 4665243.pdf
Creators: name: Czyszanowski, Tomasz
name: Sokół, Adam
name: Dems, Maciej
name: Wasiak, Michal
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplement
Can the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) Program Be Provided Online? Voices from the Youth
Creators: name: Chadi, Nicholas
name: Weisbaum, Elli
name: Malboeuf-Hurtubise, Catherine
name: Ahola Kohut, Sara
name: Viner, Christine
name: Kaufman, Miriam
name: Locke, Jake
name: Vo, Dzung X.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Mindfulness-based interventions (MBIs) have been shown to improve health and well-being in adolescents with chronic illnesses. Because they are most often delivered in person in a group setting, there are several barriers that limit access to MBIs for youth with limited mobility or who cannot access in-person MBIs in their communities. The objective of this study was to determine if eHealth is a viable platform to increase accessibility to MBIs for teens with chronic illnesses. This study reports the qualitative results of a mixed method randomized trial describing the experience of the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) program, an eight-week MBI, delivered either in person or via eHealth. Participants were adolescents between the ages of 13 and 18 with a chronic illness recruited at a tertiary pediatric hospital in Toronto, Canada. Individual semi-structured post-participation audio-video interviews were conducted by a research assistant. A multiple-pass inductive process was used to review interview transcripts and interpret emergent themes from the participants’ lived experiences. Fifteen participants (8 online and 7 in person) completed post-participation interviews. Four distinct themes emerged from participants in both groups: Creation of a safe space, fostering peer support and connection, integration of mindfulness skills into daily life, and improved well-being through the application of mindfulness. Direct quotations representative of those four themes are reported. Results from this study suggest that eHealth delivery of an adapted MBI for adolescents with chronic illnesses may be an acceptable and feasible mode of delivery for MBIs in this population. EHealth should be considered in future studies of MBIs for adolescents with chronic illnesses as a promising avenue to increase access to MBIs for youth who might not be able to access in-person programs.