Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Creators: name: Ferrão, Ygor A.
name: Giusti‐Rodriguez, Paola
name: Vallejo‐Silva, Alexie
name: Lázaro‐Muñoz, Gabriel
name: Buxbaum, Joseph D.
name: Cepeda, Sandra L.
name: Miño, Tomás
name: Frederick, Renee M.
name: la Garza, Beatriz Treviño‐de
name: Morales‐Rivero, Alonso
name: Atkinson, Elizabeth G.
name: Irreño‐Sotomonte, Jonathan
name: Jensen, Matias
name: Quarantini, Lucas C.
name: Moya, Pablo R.
name: Ochoa‐Panaifo, Marcos E.
name: Rancourt, Diana
name: Zapata‐Restrepo, Lina M.
name: Goodman, Wayne K.
name: Huang, Hailiang
name: Wiese, Andrew D.
name: Janssen‐Aguilar, Reinhard
name: Borda, Tania
name: Pereira, Stacey
name: de Los Angeles Matos, Maria
name: Gadad, Bharathi S.
name: Guintivano, Jerry
name: Arnold, Paul D.
name: Guzick, Andrew G.
name: Martinez, David A. Lozada
name: Figueroa, Edith G.
name: McGuire, Joseph F.
name: Vásquez, María I.
name: Mallen, Mayra C. Martinez
name: Rosario, Maria C.
name: Rojas, Maria Corina Ochoa
name: Ruiz‐Chow, Angel A.
name: Fragoso, Daniele T. H.
name: Prieto, María Belén
name: Weinzimmer, Saira A.
name: Grice, Dorothy E.
name: Barbosa, Izabela G.
name: Lima, Monicke O.
name: Barrera, Cynthia N.
name: Crosbie, Jennifer
name: Fay, Lucila
name: Schachar, Russell J.
name: Bracho, Belinda E. Núñez
name: Stumpf, Bárbara Perdigão
name: Daza, Luisa F.
name: Mattheisen, Manuel
name: Gonzalez‐Barrios, Polaris
name: Bigdeli, Tim B.
name: Castaman, Luis A. Olavarria
name: Stewart, S. Evelyn
name: Ayton, Daphne M.
name: Menezes, Gabriela
name: Dreher, Carolina B.
name: Orellana, Jose L. Perales
name: Moyano, María Beatriz
name: Anderberg, Jacey L.
name: Shavitt, Roseli G.
name: Reynolds, Alexandra Z. Jimenez
name: Aguirre, Cinthia
name: Garrison, Sheldon R.
name: Gonzalez, Laura D.
name: Yanez, Mauricio A.
name: Cobite, Journa
name: Miguel, Euripedes C.
name: Adorno, Victor R.
name: Saraiva, Leonardo C.
name: Khalfe, Nasim
name: Forero, Diego A.
name: Morris, Olivia J.
name: Abramowitz, Jonathan S.
name: Alves, Gustavo S.
name: Quarantini‐Alvim, Yana
name: Ramos, Iaroslava C.
name: Mithani, Sara M.
name: Chire, Jessica M.
name: Ruiz‐Velasco, Alejandra
name: Quiroz, Pamela Claisse
name: Sampaio, Aline S.
name: Paz y Mino, Mariel
name: Ramsey, Kesley A.
name: Piacsek, Kelly L.
name: Brazilian Obsessive‐Compulsive Spectrum Disorder Working Group
name: Castano, Laura Marcela Barón
name: Richter, Margaret A.
name: Berrones, Dayan
name: Munoz, Macarena Churruca
name: Minaya, Charlene
name: Comer, Jonathan S.
name: Latin American Trans‐ancestry INitiative for OCD genomics
name: Ortega, Iliana
name: Naqqash, Zainab
name: Sagarnaga, Melisa N.
name: Berardo, María Celeste
name: Cappi, Carolina
name: de, Circe Montes
name: Best, John R.
name: Duarte, Tania Pérez
name: Maye, Caitlyn E.
name: Callahan, Jennifer L.
name: Crowley, James J.
name: Storch, Eric A.
name: Chazelle, Evelyn
name: Peregrina, Tamara
name: Kook, Minjee
name: Fontenelle, Leonardo F.
name: Patrick, Ainsley K.
name: Martinez, Guadalupe Vidal
name: Hovey, Joseph D.
name: Luna, Elba S.
name: Nicolini, Humberto
name: Zai, Gwyneth
name: Timpano, Kiara R.
name: Zappa, Luz M.
name: Lanzagorta, Nuria
name: Patel, Darpan I.
name: Pato, Michele T.
name: Guttfreund, Daniel G.
name: Longhurst, Melanie O.
name: Burton, Christie L.
name: Rodriguez, Carolyn I.
name: del Río, Daniela
name: Storch, Shaina B.
name: Ruggero, Camilo J.
name: Cuevas, Vissente Tapia
name: Lack, Caleb
name: Strouphauer, Emily R.
name: Halvorsen, Matthew W.
name: Schweissing, Ethan J.
name: Zepeda‐Burgos, Raquel M.
name: de la Rosa‐Gómez, Anabel
name: González, Andres
name: Delage, Fernanda Z.
name: Riemann, Bradley C.
name: Costa, Daniel L.
name: Schneider, Sophie C.
name: Cruz, Victor O.
name: Martinez, Molly S.
name: Zoghbi, Anthony W.
name: Bracho, Ambar A. Núñez
name: Ramos, Renato T.
name: Vargas‐Medrano, Javier
name: Placencia, Maritza
name: Soileau, Keaton J.
name: Lujambio, Joali Alexandra Juárez
name: Alves, Gilberto S.
name: Fazio, Tomas
name: Knutsen, Madison A.
name: González, Marco A.
name: Rivas, Juan C.
name: Espinosa, Alejandro A. Arellano
name: Moreira‐de‐Oliveira, Maria E.
name: Muñoz, Sandra I.
name: Carneiro, Maria Cecília B.
name: Ferreira, Gabriela M.
name: Ramos, Vanessa R.
name: Seligman, Laura D.
name: Ray, Elise V.
name: Martinez‐Gonzalez, Karen G.
name: Ancalade, NaEshia
name: Dager, Guillermo
name: Marques, Andrea H.
name: Balmaceda, Trinidad Olivos
Publisher: name: Wiley
Year: 2023

description: <p>Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but &gt;95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.</p>