cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Magnesium and zinc fertilisation improves rice yield and yield component responses to nitrogen, phosphorus, and potassium
Creators: name: Anago, Firmin N
name: Agbangba, Emile C
name: Oussou, Brice C T
name: Dagbénonbakin, Gustave D
name: Amadji, Lucien G
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: The aim of this study was to assess the effects of magnesium (Mg) and zinc (Zn) on the response of rice to nitrogen (N), phosphorus (P), and potassium (K) application. Two sets of field experiments were carried out in Benin. A Box Behnken Design with eight replications per year with treatments of N, P, potassium (K), Mg, and Zn was used for the first experiment, while a randomised complete block design with five treatments varying in Mg and Zn was used for the second experiment. Co-application of major nutrients with Mg and/or Zn significantly increased rice yield and nutrient use efficiencies. Co-application of N and Mg increased grain yield, filled grain rate, and 1 000 grains weight by 53.5, 7.10, and 7.34%, respectively. Likewise, the co-application of N with Zn increased rice yield, panicles per plant, and spikelets per panicle by 35.69, 14.78, and 6.06%, respectively. When P was co-applied with Zn, grain yield, spikelets per panicle, and the 1 000 grains weight increased by 27.21, 5.71, and 6.20%, respectively. The co-application of K with Mg led to an increase of grain yield and filling of grain by 24.28, and 5.71%, respectively. This study revealed the positive effects of Mg and Zn on rice yield response to the application of N, P, and K.
The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
Creators: name: Best, Lyle G.
name: MacCluer, Jean W.
name: Howard, Barbara V.
name: Franceschini, Nora
name: Umans, Jason G.
name: North, Kari E.
name: Laston, Sandy
name: Voruganti, V. Saroja
name: Göring, Harald H. H.
name: Haack, Karin
name: Almasy, Laura
name: Cole, Shelley A.
name: Fabsitz, Richard R.
name: Lee, Elisa T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Chronic kidney disease (CKD) is an important public health problem in American Indian populations. Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD in African-Americans. Whether these associations are also present among American Indian individuals is unknown. To evaluate the role of genetic polymorphisms in the MYH9 gene on kidney disease in American Indians, we genotyped 25 SNPs in the MYH9 gene region in 1,119 comparatively unrelated individuals. Four SNPs failed, and one SNP was monomorphic. We inferred haplotypes using seven SNPs within the region of the previously described E haplotype using Phase v2.1. We studied the association between 20 MYH9 SNPs with kidney function (estimated glomerular filtration rate, eGFR) and CKD (eGFR < 60 ml/min/1.73 m2 or renal replacement therapy or kidney transplant) using age-, sex- and center-adjusted models and measured genotyped within the variance component models. MYH9 SNPs were not significantly associated with kidney traits in additive or recessive genetic adjusted models. MYH9 haplotypes were also not significantly associated with kidney outcomes. In conclusion, common variants in MYH9 polymorphisms may not confer an increased risk of CKD in American Indian populations. Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians.
Using public control genotype data to increase power and decrease cost of case–control genetic association studies
Creators: name: Ho, Lindsey A.
name: Lange, Ethan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Genome-wide association (GWA) studies are a powerful approach for identifying novel genetic risk factors associated with human disease. A GWA study typically requires the inclusion of thousands of samples to have sufficient statistical power to detect single nucleotide polymorphisms (SNPs) that are associated with only modest increases in risk of disease given the heavy burden of a multiple test correction that is necessary to maintain valid statistical tests. Low statistical power and the high financial cost of performing a GWA study remains prohibitive for many scientific investigators anxious to perform such a study using their own samples. A number of remedies have been suggested to increase statistical power and decrease cost, including the utilization of free publicly available genotype data and multi-stage genotyping designs. Herein, we compare the statistical power and relative costs of alternative association study designs that use cases and screened controls to study designs that are based only on, or additionally include, free public control genotype data. We describe a novel replication-based two-stage study design, which uses free public control genotype data in the first stage and follow-up genotype data on case-matched controls in the second stage, that preserves many of the advantages inherent when using only an epidemiologically matched set of controls. Specifically, we show that our proposed two-stage design can substantially increase statistical power and decrease cost of performing a GWA study while controlling the type I error rate that can be inflated when using public controls due to differences in ancestry and batch genotype effects.
Segregation in spatially structured cities
Creators: name: Ortega, Diego
name: Rodríguez-Laguna, Javier
name: Korutcheva, Elka
Publisher: name: arXiv
Year: 2022
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Half of the world population resides in cities and urban segregation is becoming a global issue. One of the best known attempts to understand it is the Schelling model, which considers two types of agents that relocate whenever a transfer rule depending on the neighbor distribution is verified. The main aim of the present study is to broaden our understanding of segregated neighborhoods in the city, i.e. ghettos, extending the Schelling model to consider economic aspects and their spatial distribution. To this end we have considered a monetary gap between the two social groups and five types of urban structures, defined by the house pricing city map. The results show that ghetto sizes tend to follow a power law distribution in all the considered cases. For each city framework the interplay between economical aspects and the geometrical features determine the location where ghettos reach their maximum size. The system first steps shape greatly the city's final appearance. Moreover, the segregated population ratios depends largely on the monetary gap and not on the city type, implying that ghettos are able to adapt to different urban frameworks.
description: 16 pages, 8 figures
ความรู้ความเข้าใจในการปฏิบัติงานด้านการเงินและบัญชีของเจ้าหน้าที่การเงินและบัญชีในมหาวิทยาลัยมหาสารคาม
Creators: name: นภาพร อุดมลาภ
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Operation
Finance
Accounting Officer
Mahasarakham University

description: Journal of Politics and Governance, 10, 1, 238-252
Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
Creators: name: Lange, Leslie A.
name: Folsom, Aaron R.
name: Keating, Brendan J.
name: Mohler III, Emile R.
name: McCarroll, Steven A.
name: Reiner, Alexander P.
name: O’Donnell, Christopher J.
name: Tracy, Russell P.
name: Wilson, James G.
name: Grant, Struan F. A.
name: Palmas, Walter
name: Lettre, Guillaume
name: Lo, Ken Sin
name: Tang, Weihong
name: Galarneau, Geneviève
name: Ganesh, Santhi K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Red blood cell, white blood cell, and platelet measures, including their count, sub-type and volume, are important diagnostic and prognostic clinical parameters for several human diseases. To identify novel loci associated with hematological traits, and compare the architecture of these phenotypes between ethnic groups, the CARe Project genotyped 49,094 single nucleotide polymorphisms (SNPs) that capture variation in ~2,100 candidate genes in DNA of 23,439 Caucasians and 7,112 African Americans from five population-based cohorts. We found strong novel associations between erythrocyte phenotypes and the glucose-6 phosphate dehydrogenase (G6PD) A-allele in African Americans (rs1050828, P < 2.0 × 10−13, T-allele associated with lower red blood cell count, hemoglobin, and hematocrit, and higher mean corpuscular volume), and between platelet count and a SNP at the tropomyosin-4 (TPM4) locus (rs8109288, P = 3.0 × 10−7 in Caucasians; P = 3.0 × 10−7 in African Americans, T-allele associated with lower platelet count). We strongly replicated many genetic associations to blood cell phenotypes previously established in Caucasians. A common variant of the α-globin (HBA2-HBA1) locus was associated with red blood cell traits in African Americans, but not in Caucasians (rs1211375, P < 7 × 10−8, A-allele associated with lower hemoglobin, mean corpuscular hemoglobin, and mean corpuscular volume). Our results show similarities but also differences in the genetic regulation of hematological traits in European- and African-derived populations, and highlight the role of natural selection in shaping these differences.
Quantifying uncertainties on excursion sets under a Gaussian random field prior
Creators: name: Azzimonti, Dario
name: Bect, Julien
name: Chevalier, Clément
name: Ginsbourger, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: Computation (stat.CO)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We focus on the problem of estimating and quantifying uncertainties on the excursion set of a function under a limited evaluation budget. We adopt a Bayesian approach where the objective function is assumed to be a realization of a Gaussian random field. In this setting, the posterior distribution on the objective function gives rise to a posterior distribution on excursion sets. Several approaches exist to summarize the distribution of such sets based on random closed set theory. While the recently proposed Vorob'ev approach exploits analytical formulae, further notions of variability require Monte Carlo estimators relying on Gaussian random field conditional simulations. In the present work we propose a method to choose Monte Carlo simulation points and obtain quasi-realizations of the conditional field at fine designs through affine predictors. The points are chosen optimally in the sense that they minimize the posterior expected distance in measure between the excursion set and its reconstruction. The proposed method reduces the computational costs due to Monte Carlo simulations and enables the computation of quasi-realizations on fine designs in large dimensions. We apply this reconstruction approach to obtain realizations of an excursion set on a fine grid which allow us to give a new measure of uncertainty based on the distance transform of the excursion set. Finally we present a safety engineering test case where the simulation method is employed to compute a Monte Carlo estimate of a contour line.
Topological Polaritons in a Quantum Spin Hall Cavity
Creators: name: Janot, Alexander
name: Rosenow, Bernd
name: Refael, Gil
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the topological structure of matter-light excitations, so called polaritons, in a quantum spin Hall insulator coupled to photonic cavity modes. We identify a topological invariant in the presence of time reversal (TR) symmetry, and demonstrate the existence of a TR-invariant topological phase. We find protected helical edge states with energies below the lower polariton branch and characteristic uncoupled excitonic states, both detectable by optical techniques. Applying a Zeeman field allows us to relate the topological index to the double coverage of the Bloch sphere by the polaritonic pseudospin.
description: 5 pages + 4 pages supplemental material, 3 figures
ความแตกต่างระหว่างเพศ โค้งพัฒนาการตามอายุ และแนวโน้มของค่าใช้จ่ายประเภทผู้ป่วยในและผู้ป่วยนอกของสิทธิรักษาพยาบาลข้าราชการ
Creators: name: มัณฑนา จาดสอน
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Age Trajectories
Civil Servant Medical Benefit Scheme (CSMBS)
IPD and OPD Costs
Curve Fitting

description: Journal of Politics and Governance, 10, 1, 253-267
การจัดการปกครองแบบร่วมมือกัน (Collaborative Governance) ในโครงการอุตสาหกรรมเพื่อการสร้างงานที่ยั่งยืนในพื้นที่ 3 จังหวัดชายแดนภาคใต้
Creators: name: คอรี การีจิ
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Collaborative Governance
Industrial Project
Sustainable Job Creation
Southern Border Provinces in Thailand

description: Journal of Politics and Governance, 10, 2, 1-20
การสร้างอิทธิพลของผู้มีส่วนได้ส่วนเสียในกระบวนการนโยบายสาธารณะของไทย: กรณีโรงไฟฟ้าพลังความร้อน (ถ่านหิน) กระบี่
Creators: name: เขมภัฏ ห้วยลึก
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Policy Process
Stakeholder
Influencing
Coal Power Plant

description: Journal of Politics and Governance, 10, 2, 21-47
Neural Implementation of Probabilistic Models of Cognition
Creators: name: Kharratzadeh, Milad
name: Shultz, Thomas R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Bayesian models of cognition hypothesize that human brains make sense of data by representing probability distributions and applying Bayes' rule to find the best explanation for available data. Understanding the neural mechanisms underlying probabilistic models remains important because Bayesian models provide a computational framework, rather than specifying mechanistic processes. Here, we propose a deterministic neural-network model which estimates and represents probability distributions from observable events --- a phenomenon related to the concept of probability matching. Our model learns to represent probabilities without receiving any representation of them from the external world, but rather by experiencing the occurrence patterns of individual events. Our neural implementation of probability matching is paired with a neural module applying Bayes' rule, forming a comprehensive neural scheme to simulate human Bayesian learning and inference. Our model also provides novel explanations of base-rate neglect, a notable deviation from Bayes.
Line defects in the small elastic constant limit of a three-dimensional Landau-de Gennes model
Creators: name: Canevari, Giacomo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 76A15, 35J57, 35B40, 35A20

description: We consider the Landau-de Gennes variational model for nematic liquid crystals, in three-dimensional domains. More precisely, we study the asymptotic behaviour of minimizers as the elastic constant tends to zero, under the assumption that minimizers are uniformly bounded and their energy blows up as the logarithm of the elastic constant. We show that there exists a closed set S of finite length, such that minimizers converge to a locally harmonic map away from S. Moreover, S restricted to the interior of the domain is a locally finite union of straight line segments. We provide sufficient conditions, depending on the domain and the boundary data, under which our main results apply. We also discuss some examples.
description: 71 pages, 5 figures
XIX МЕЖДУНАРОДНАЯ НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ «Развитие науки и практики в глобально меняющемся мире в условиях рисков»
Creators: name: ООО "Институт развития образования и консалтинга"
Publisher: name: ООО "Институт развития образования и консалтинга"
Year: 2023

description: XIX МЕЖДУНАРОДНАЯ НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ «Развитие науки и практики в глобально меняющемся мире в условиях рисков»
ผลการดำเนินงานตามนโยบายเขตพัฒนาเศรษฐกิจพิเศษ: กรณีศึกษาจังหวัดสระแก้ว*
Creators: name: ชิตพล ชัยมะดัน
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Operation
Policy
Special Economic Zone

description: Journal of Politics and Governance, 10, 2, 48-66
บทเรียนการระงับข้อพิพาททางเลือกจากต่างประเทศและการนำมาใช้กับคดีสิ่งแวดล้อมของประเทศไทย
Creators: name: ศักดิ์ชาย สุนทรธนาภิรมย์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Environmental Cases
Dispute Resolution
Alternative Dispute Resolution

description: Journal of Politics and Governance, 10, 2, 67-86
ภาษาในรัฐธรรมนูญไทย: เปรียบเทียบรัฐธรรมนูญ พ.ศ. 2540 กับรัฐธรรมนูญ พ.ศ. 2560
Creators: name: อุไรวรรณ ธนสถิตย์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Constitution
2017 Thai Constitutions
Democracy

description: Journal of Politics and Governance, 10, 2, 87-103
มาตรการทางกฎหมายในการปราบปรามการลักลอบขนผู้โยกย้ายถิ่นฐานทางบก
Creators: name: กรวิไล เทพพันธ์กุลงาม
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Protocol against the Smuggling
Suppression of smuggling of migrants

description: Journal of Politics and Governance, 10, 2, 104-123
Scaling-up Empirical Risk Minimization: Optimization of Incomplete U-statistics
Creators: name: Clémençon, Stéphan
name: Bellet, Aurélien
name: Colin, Igor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: In a wide range of statistical learning problems such as ranking, clustering or metric learning among others, the risk is accurately estimated by $U$-statistics of degree $d\geq 1$, i.e. functionals of the training data with low variance that take the form of averages over $k$-tuples. From a computational perspective, the calculation of such statistics is highly expensive even for a moderate sample size $n$, as it requires averaging $O(n^d)$ terms. This makes learning procedures relying on the optimization of such data functionals hardly feasible in practice. It is the major goal of this paper to show that, strikingly, such empirical risks can be replaced by drastically computationally simpler Monte-Carlo estimates based on $O(n)$ terms only, usually referred to as incomplete $U$-statistics, without damaging the $O_{\mathbb{P}}(1/\sqrt{n})$ learning rate of Empirical Risk Minimization (ERM) procedures. For this purpose, we establish uniform deviation results describing the error made when approximating a $U$-process by its incomplete version under appropriate complexity assumptions. Extensions to model selection, fast rate situations and various sampling techniques are also considered, as well as an application to stochastic gradient descent for ERM. Finally, numerical examples are displayed in order to provide strong empirical evidence that the approach we promote largely surpasses more naive subsampling techniques.
description: To appear in Journal of Machine Learning Research. 34 pages. v2: minor correction to Theorem 4 and its proof, added 1 reference. v3: typo corrected in Proposition 3. v4: improved presentation, added experiments on model selection for clustering, fixed minor typos
Portfolio Optimization under Shortfall Risk Constraint
Creators: name: Janke, Oliver
name: Li, Qinghua
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Finance (q-fin.MF)
subject: Portfolio Management (q-fin.PM)
subject: FOS: Economics and business

description: This paper solves a utility maximization problem under utility-based shortfall risk constraint, by proposing an approach using Lagrange multiplier and convex duality. Under mild conditions on the asymptotic elasticity of the utility function and the loss function, we find an optimal wealth process for the constrained problem and characterize the bi-dual relation between the respective value functions of the constrained problem and its dual. This approach applies to both complete and incomplete markets. Moreover, the extension to more complicated cases is illustrated by solving the problem with a consumption process added. Finally, we give an example of utility and loss functions in the Black-Scholes market where the solutions have explicit forms.
description: 25 pages, Optimization, 2016
Operator Lipschitz functions on Banach spaces
Creators: name: Rozendaal, Jan
name: Sukochev, Fedor
name: Tomskova, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: Primary 47A55, 47A56, Secondary 47B47

description: Let $X$, $Y$ be Banach spaces and let $\mathcal{L}(X,Y)$ be the space of bounded linear operators from $X$ to $Y$. We develop the theory of double operator integrals on $\mathcal{L}(X,Y)$ and apply this theory to obtain commutator estimates of the form $\|f(B)S-Sf(A)\|_{\mathcal{L}(X,Y)}\leq \textrm{const} \|BS-SA\|_{\mathcal{L}(X,Y)}$ for a large class of functions $f$, where $A\in\mathcal{L}(X)$, $B\in \mathcal{L}(Y)$ are scalar type operators and $S\in \mathcal{L}(X,Y)$. In particular, we establish this estimate for $f(t):=|t|$ and for diagonalizable operators on $X=\ell_{p}$ and $Y=\ell_{q}$, for $p
description: Final version published in Studia Mathematica, with some minor changes
Experimental violation of Bell inequalities for multi-dimensional systems
Creators: name: Lo, Hsin-Pin
name: Li, Che-Ming
name: Yabushita, Atsushi
name: Chen, Yueh-Nan
name: Luo, Chih-Wei
name: Kobayashi, Takayoshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Quantum correlations between spatially separated parts of a $d$-dimensional bipartite system ($d\geq 2$) have no classical analog. Such correlations, also called entanglements, are not only conceptually important, but also have a profound impact on information science. In theory the violation of Bell inequalities based on local realistic theories for $d$-dimensional systems provides evidence of quantum nonlocality. Experimental verification is required to confirm whether a quantum system of extremely large dimension can possess this feature, however it has never been performed for large dimension (e.g., $d\geq 1000$). Here, we report that Bell inequalities are experimentally violated for bipartite quantum systems of extremely high dimensionality with the usual ensembles of polarization-entangled photon pairs. Our entanglement source violates Bell inequalities for extremely high dimensionality of $d>4000$. The designed scenario offers a possible new method to investigate the entanglement of multipartite systems of large dimensionality and their application in quantum information processing.
การใช้หลักพุทธธรรมในกระบวนการเจรจาไกล่เกลี่ยความขัดแย้งในชุมชนของผู้ใหญ่บ้านและคณะกรรมการหมู่บ้านศึกษากรณี บ้านเขวากลาง หมู่ 2 ตำบลเขวาใหญ่อำเภอกันทรวิชัย จังหวัดมหาสารคาม
Creators: name: วิศิษฏ์ เจนนานนท์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Mediation
Conflict
Buddhadhamma

description: Journal of Politics and Governance, 10, 2, 124-139
Genetic variants in TLR2 and TLR4 are associated with markers of monocyte activation: the Atherosclerosis Risk in Communities MRI Study
Creators: name: Boerwinkle, Eric
name: Pankow, James S.
name: Chambless, Lloyd
name: He, Max
name: Hall, Jennifer L.
name: Bielinski, Suzette J.
name: Folsom, Aaron R.
name: Matijevic-Aleksic, Nena
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Markers of monocyte activation play a critical role in atherosclerosis, but little is known about the genetic influences on cellular levels. Therefore, we investigated the influence of genetic variants in monocyte differentiation antigen (CD14), toll-like receptor-4 (TLR4), toll-like receptor-2 (TLR2), and myeloperoxidase (MPO) on monocyte surface receptor levels. The study sample consisted of 1,817 members of a biracial cohort of adults from the Atherosclerosis Risk in Communities Carotid MRI Study. Monocyte receptors were measured using flow cytometry on fasting whole blood samples. TLR2 rs1816702 genotype was significantly associated with CD14+/TLR2+ percent of positive cells (%) and median fluorescence intensity (MFI) in whites but not in blacks (p < 0.001). Specifically, the presence of the minor T-allele was associated with increased receptor levels. In blacks, TLR4 rs5030719 was significantly associated with CD14+/TLR4+ monocytes (MFI) with mean ± SE intensities of 16.7 ± 0.05 and 16.0 ± 0.14 for GG and GT/TT genotypes, respectively (p < 0.001). Variants in TLR2 and TLR4 were associated with monocyte receptor levels of TLR2 and TLR4, respectively, in a biracial cohort of adults. To our knowledge, this is the first study to look at associations between variants in the toll-like receptor family and toll-like receptor levels on monocytes.
Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16
Creators: name: Dawson, Geraldine
name: Chapman, Nicola H.
name: Schellenberg, Gerard D.
name: Estes, Annette
name: Webb, Sara J.
name: Bernier, Raphael
name: Wijsman, Ellen M.
name: Rothstein, Joseph H.
name: Minshew, Nancy J.
name: Munson, Jeff
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Performance IQ (PIQ) greater than verbal IQ (VIQ) is often observed in studies of the cognitive abilities of autistic individuals. This characteristic is correlated with social and communication impairments, key parts of the autism diagnosis. We present the first genetic analyses of IQ discrepancy (PIQ–VIQ) as an autism-related phenotype. We performed genome-wide joint linkage and segregation analyses on 287 multiplex families, using a Markov chain Monte Carlo approach. Genetic data included a genome-scan of 387 micro-satellite markers in 210 families augmented with additional markers added in a subset of families. Empirical P values were calculated for five interesting regions. Linkage analysis identified five chromosomal regions with substantial regional evidence of linkage; 10p12 [P = 0.001; genome-wide (gw) P = 0.05], 16q23 (P = 0.015; gw P = 0.53), 2p21 (P = 0.03, gw P = 0.78), 6q25 (P = 0.047, gw P = 0.91) and 15q23–25 (P = 0.053, gw P = 0.93). The location of the chromosome 10 linkage signal coincides with a region noted in a much earlier genome-scan for autism, and the chromosome 16 signal coincides exactly with a linkage signal for non-word repetition in specific language impairment. This study provides strong evidence for a QTL influencing IQ discrepancy in families with autistic individuals on chromosome 10, and suggestive evidence for a QTL on chromosome 16. The location of the chromosome 16 signal suggests a candidate gene, CDH13, a T-cadherin expressed in the brain, which has been implicated in previous SNP studies of autism and ADHD.
Bayesian Indirect Inference and the ABC of GMM
Creators: name: Creel, Michael
name: Gao, Jiti
name: Hong, Han
name: Kristensen, Dennis
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: We propose and study local linear and polynomial based nonparametric regression methods for implementing Approximate Bayesian Computation (ABC) style indirect inference and
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder
Creators: name: Shah, Naisha
name: Bolshakova, Nadia
name: Foley, Suzanne
name: Cali, Phil
name: Anney, Richard
name: Dawson, Geraldine
name: Conroy, Judith M.
name: Estes, Annette
name: Duketis, Eftichia
name: Casey, Jillian P.
name: Bourgeron, Thomas
name: Coutanche, Marc
name: Battaglia, Agatino
name: Bacchelli, Elena
name: Folstein, Susan E.
name: Delorme, Richard
name: Farrar, Penny
name: Correia, Catarina
name: Fernandez, Bridget A.
name: Abrahams, Brett S.
name: de Jonge, Maretha
name: Baird, Gillian
name: Almeida, Joana
name: Regan, Regina
name: Magalhaes, Tiago
name: Bolton, Patrick F.
name: Bailey, Anthony J.
name: Shields, Denis C.
name: Duque, Frederico
name: Brennan, Sean
name: Corsello, Christina
name: Berney, Tom
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.Electronic supplementary materialThe online version of this article (doi:10.1007/s00439-011-1094-6) contains supplementary material, which is available to authorized users.
Glueball Decay Rates in the Witten-Sakai-Sugimoto Model
Creators: name: Brünner, Frederic
name: Parganlija, Denis
name: Rebhan, Anton
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We revisit and extend previous calculations of glueball decay rates in the Sakai-Sugimoto model, a holographic top-down approach for QCD with chiral quarks based on D8 probe branes in Witten's holographic model of nonsupersymmetric Yang-Mills theory. The rates for decays into two pions, two vector mesons, four pions, and the strongly suppressed decay into four pi0 are worked out quantitatively, using a range of the 't Hooft coupling which closely reproduces the decay rate of rho and omega mesons and also leads to a gluon condensate consistent with QCD sum rule calculations. The lowest holographic glueball, which arises from a rather exotic polarization of gravitons in the supergravity background, turns out to have a significantly lower mass and larger width than the two widely discussed glueball candidates f0(1500) and f0(1710). The lowest nonexotic and predominantly dilatonic scalar mode, which has a mass of 1487 MeV in the Witten-Sakai-Sugimoto model, instead provides a narrow glueball state, and we conjecture that only this nonexotic mode should be identified with a scalar glueball component of f0(1500) or f0(1710). Moreover the decay pattern of the tensor glueball is determined, which is found to have a comparatively broad total width when its mass is adjusted to around or above 2 GeV.
description: 38 pages, 5 figures, 9 tables; v2: minor corrections (numerical data in tables 3, 5, and 7 on excited scalar glueballs), 2 footnotes and 2 references added; v3: corrections in table 9 (extrapolations of tensor glueball decay to masses above 2 GeV)
Recommendations for ethical approaches to genotype-driven research recruitment
Creators: name: Nelson, Daniel K.
name: Beskow, Laura M.
name: Wilfond, Benjamin S.
name: Davis, Arlene M.
name: Fullerton, Stephanie M.
name: Namey, Emily E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Recruiting research participants based on genetic information generated about them in a prior study is a potentially powerful way to study the functional significance of human genetic variation. However, it also presents significant ethical challenges that, to date, have received only minimal consideration. We convened a multi-disciplinary workshop to discuss key issues relevant to the conduct and oversight of genotype-driven recruitment and to translate those considerations into practical policy recommendations. Workshop participants were invited from around the U.S., and included genomic researchers and study coordinators, research participants, clinicians, bioethics scholars, experts in human research protections, and government representatives. Discussion was directed by experienced facilitators and informed by empirical data collected in a national survey of IRB chairs and in-depth interviews with research participants in studies where genotype-driven recontact occurred. A high degree of consensus was attained on the resulting 7 recommendations, which cover informed consent disclosures and choices, the process for how and by whom participants are recontacted, the disclosure of individual genetic research results, and the importance of tailoring approaches based on specific contextual factors. These recommendations are intended to represent a balanced approach—protecting research participants, yet avoiding overly restrictive policies that hinder advancement on important scientific questions.
A reexamination of the effective fine structure constant of graphene, as measured in graphite
Creators: name: Gan, Yu
name: Munoz, Gilberto de la Pena
name: Kogar, Anshul
name: Uchoa, Bruno
name: Casa, Diego
name: Gog, Thomas
name: Fradkin, Eduardo
name: Abbamonte, Peter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a refined and improved study of the influence of screening on the effective fine structure constant of graphene, $α^*$, as measured in graphite using inelastic x-ray scattering. This follow-up to our previous study [J. P. Reed, et al., Science 330, 805 (2010)] was carried out with two times better energy resolution, five times better momentum resolution, and improved experimental setup with lower background. We compare our results to RPA calculations and evaluate the relative importance of interlayer hopping, excitonic corrections, and screening from high energy excitations involving the $σ$ bands. We find that the static, limiting value of $α^*$ falls in the range 0.25 to 0.35, which is higher than our previous result of 0.14, but still below the value expected from RPA. We show the reduced value is not a consequence of interlayer hopping effects, which were ignored in our previous analysis, but of a combination of excitonic effects in the $π\rightarrow π^*$ particle-hole continuum, and background screening from the $σ$-bonded electrons. We find that $σ$-band screening is extremely strong at distances of the order of a few nm, and should be highly effective at screening out short-distance, Hubbard-like interactions in graphene, as well as other carbon allotropes.
description: 23 pages, 5 figures
Estimation of Technical Change and Price Elasticities: A Categorical Time-varying Coefficient Approach
Creators: name: Feng, Guohua
name: Gao, Jiti
name: Zhang, Xiaohui
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: In this paper we outline new procedure for estimating technical change and price elasticities. Specifically, we propose a categorical time-varying coefficient translog cost
Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)
Creators: name: Schaid, Daniel J.
name: Cancel-Tassin, Geraldine
name: Jin, Guangfu
name: Teerlink, Craig C.
name: FitzGerald, Liesel M.
name: Severi, Gianluca
name: Lange, Ethan M.
name: Walsh, Patrick C.
name: Camp, Nicola J.
name: Cannon-Albright, Lisa A.
name: Cooney, Kathleen A.
name: Hopper, John L.
name: Egrot, Christophe
name: Lu, Lingyi
name: Easton, Doug
name: Maier, Christiane
name: Wiley, Kathleen E.
name: Giles, Graham G.
name: Vogel, Walther
name: Foulkes, William D.
name: Kote-Jarai, Zsofia
name: Rinckleb, Antje
name: Stanford, Janet L.
name: Guy, Michelle
name: Ray, Anna M.
name: Zuhlke, Kimberly A.
name: Eeles, Ros
name: Thibodeau, Stephen N.
name: Isaacs, Sarah D.
name: Cussenot, Olivier
name: Wiklund, Fredrik
name: McDonnell, Shannon K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case–control designs. However, GWAS findings may be confounded by population stratification if cases and controls are inadvertently drawn from different genetic backgrounds. In addition, since these loci were identified in cases with predominantly sporadic disease, little is known about their relationships with hereditary prostate cancer (HPC). The association between seventeen reported PCa susceptibility loci was evaluated with a family-based association test using 1,979 hereditary PCa families of European descent collected by members of the International Consortium for Prostate Cancer Genetics, with a total of 5,730 affected men. The risk alleles for 8 of the 17 loci were significantly over-transmitted from parents to affected offspring, including SNPs residing in 8q24 (regions 1, 2 and 3), 10q11, 11q13, 17q12 (region 1), 17q24 and Xp11. In subgroup analyses, three loci, at 8q24 (regions 1 and 2) plus 17q12, were significantly over-transmitted in hereditary PCa families with five or more affected members, while loci at 3p12, 8q24 (region 2), 11q13, 17q12 (region 1), 17q24 and Xp11 were significantly over-transmitted in HPC families with an average age of diagnosis at 65 years or less. Our results indicate that at least a subset of PCa risk-related loci identified by case–control GWAS are also associated with disease risk in HPC families.
Long-term forecasts of age-specific participation rates with functional data models
Creators: name: Url, Thomas
name: Hyndman, Rob J
name: Dokumentov, Alexander
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: Many countries have implemented social programs providing long-term financial or in-kind entitlements. These programs often focus on specific age-groups and consequently their expenditure streams are subject to demographic change. Given the strains already existing on public budgets, long-term forecasts are an increasingly important instrument to monitor the budgetary consequences of social programs. The expected development of the labour force is a key input to these forecasts. We Produce forecasts of age-specific labour market participation rates, combining a functional data approach with information on education, marital status and other exogenous variables.
Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
Creators: name: Mursaleen, Leah
Publisher: name: University of Westminster
Year: 2021

description: In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in sustained oxidative stress and cellular damage. The blood‐brain barrier (BBB) prevents most pharmaceuticals from entering the brain, therefore, to enable the advancement of potential antioxidant and iron chelator therapies for PD, limiting factors such as brain penetrance and bioavailability need to be overcome. This study aimed to develop novel nanocarrier delivery systems of the antioxidants curcumin, n‐acetylcysteine (NAC) and hydroxytyrosol (HT), alone or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in sustained oxidative stress and cellular damage. The blood‐brain barrier (BBB) prevents most pharmaceuticals from entering the brain, therefore, to enable the advancement of potential antioxidant and iron chelator therapies for PD, limiting factors such as brain penetrance and bioavailability need to be overcome. This study aimed to develop novel nanocarrier delivery systems of the antioxidants curcumin, n‐acetylcysteine (NAC) and hydroxytyrosol (HT), alone or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model.
On small set of one-way LOCC indistinguishability of maximally entangled states
Creators: name: Wang, Yan-Ling
name: Zheng, Zhu-Jun
name: Fei, Shao-Ming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we study the one-way local operations and classical communication (LOCC) problem. In $\mathbb{C}^d\otimes\mathbb{C}^d$ with $d\geq4$, we construct a set of $3\lceil\sqrt{d}\rceil-1$ one-way LOCC indistinguishable maximally entangled states which are generalized Bell states. Moreover, we show that there are four maximally entangled states which cannot be perfectly distinguished by one-way LOCC measurements for any dimension $d\geq 4$.
description: 10 pages.Very recently, we became aware of related work \cite{Zhang2} in which the same $\lceil\frac{d}{2}\rceil+2$ states in $\mathbb{C}^d\otimes\mathbb{C}^d$ is proved to be one-way LOCC indistinguishable. arXiv admin note: text overlap with arXiv:1310.4220 by other author
A genome-wide association study of breast cancer in women of African ancestry
Creators: name: Ogundiran, Temidayo O.
name: Chen, Fang
name: John, Esther M.
name: Chanock, Stephen J.
name: Cox, Nancy J.
name: Palmer, Julie R.
name: Zheng, Wei
name: Bernstein, Leslie
name: Hu, Jennifer J.
name: Cai, Qiuyin
name: Nyante, Sarah
name: Ambrosone, Christine B.
name: Bandera, Elisa V.
name: Ruiz-Narvaez, Edward A.
name: Long, Jirong
name: Ziegler, Regina G.
name: Adebamowo, Clement
name: Rodriguez-Gil, Jorge L.
name: Huo, Dezheng
name: Chen, Gary K.
name: Blot, William
name: Stram, Daniel O.
name: DeMichele, Angela
name: Li, Guoliang
name: Millikan, Robert C.
name: Zheng, Yonglan
name: Signorello, Lisa
name: Rebbeck, Tim R.
name: Olopade, Olufunmilayo I.
name: Ingles, Sue A.
name: Deming, Sandra L.
name: Press, Michael F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ancestry, with genotyping of > 1,000,000 SNPs in 3,153 African American cases and 2,831 controls, and replication testing of the top 66 associations in an additional 3,607 breast cancer cases and 11,330 controls of African ancestry. Two of the 66 SNPs replicated (p < 0.05) in stage 2, which reached statistical significance levels of 10−6 and 10−5 in the stage 1 and 2 combined analysis (rs4322600 at chromosome 14q31: OR = 1.18, p = 4.3×10−6; rs10510333 at chromosome 3p26: OR = 1.15, p = 1.5×10−5). These suggestive risk loci have not been identified in previous GWAS in other populations and will need to be examined in additional samples. Identification of novel risk variants for breast cancer in women of African ancestry will demand testing of a substantially larger set of markers from stage 1 in a larger replication sample.
On conformal maps from multiply connected domains onto lemniscatic domains
Creators: name: Sète, Olivier
name: Liesen, Jörg
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30C35, 30C20

description: We study conformal maps from multiply connected domains in the extended complex plane onto lemniscatic domains. Walsh proved the existence of such maps in 1956 and thus obtained a direct generalization of the Riemann mapping theorem to multiply connected domains. For polynomial pre-images of simply connected sets we derive a construction principle for Walsh's conformal map in terms of the Riemann map for the simply connected set. Moreover, we explicitly construct examples of Walsh's conformal map for certain radial slit domains and circular domains.
description: Added a remark for a generalization of Theorem 4.2