cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Building polarization into protein-inhibitor binding dynamics in rational drug design for rheumatoid arthritis
Creators: name: Sandhu, Gurvisha
name: Agrawal, Praveen
name: Bose, Surojit
name: Thelma, B. K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Standard force field-based simulations to accomplish structure-based evaluations of lead molecules is a powerful tool. Combining protein fragmentation into tractable sub-systems with continuum solvation method is envisaged to enable quantum mechanics-based electronic structure calculations of macromolecules in their realistic environment. This along with incorporation of many-body polarization effect in molecular dynamics simulations may augment an accurate description of electrostatics of protein-inhibitor systems for effective drug design. Rheumatoid arthritis (RA) is a complex autoimmune disorder plagued by the ceiling effect of current targeted therapies, encouraging identification of new druggable targets and corresponding drug design to tackle the refractory form of disease. In this study, polarization-inclusive force field approach has been used to model protein solvation and ligand binding for ‘Mitogen-activated protein kinase’ (MAP3K8), a regulatory node of notable pharmacological relevance in RA synovial biology. For MAP3K8 inhibitors belonging to different scaffold series, the calculations illustrated differential electrostatic contribution to their relative binding affinities and successfully explained examples from available structure-activity relationship studies. Results from this study exemplified i) the advantage of this approach in reliably ranking inhibitors having close nanomolar range activities for the same target; and ii) its prospective application in lead molecule identification aiding drug discovery efforts in RA. Communicated by Ramaswamy H. Sarma
Geonoma pinnatifrons subsp. ramosissima Henderson
Creators: name: Henderson, Andrew
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Arecales
Arecaceae
Geonoma
Geonoma pinnatifrons
Geonoma pinnatifrons subsp. ramosissima (burret) henderson

description: 49h. Geonoma pinnatifrons subsp. ramosissima (Burret) Henderson, comb. & stat. nov.
Basionym: Geonoma ramosissima Burret (1930a: 249). Type: COLOMBIA. Antioquia: Cieneguetas, 27 July 1880, W. Kalbreyer 1892 (holotype B, destroyed). Neotype (selected by Bernal et al. 1989): COLOMBIA. Antioquia: Mun. Frontino, Corregimiento de Murrí, road from Nutibara to La Blanquita, Río Cuevas, 950 m, 23 March 1982, R. Bernal & G. Galeano 306 (neotype COL!, isoneotype NY!).
Leaf pinnae 15(12–17) per side of rachis. Inflorescences peduncular bracts inserted 1.3(1.0–1.5) cm above the prophyll; peduncles 19.3(16.5–22.0) cm long, 18.2(15.2–21.2) mm in diameter; rachillae 11.4(7.0–16.0) cm long, 1.6(1.1–2.3) mm in diameter; fruits 3.8(3.5–4.0) mm in diameter.
Distribution:— From 3°55’– 7°00’N and 75°54’– 77°37’W on the Pacific Coast and western slopes of the Western Cordillera in Colombia, at 427(0–1150) m elevation in lowland to montane rainforest (Fig. 32).
There is geographic discontinuity but too few specimens to test for differences, and too few to test for geographical variation. Three specimens (Bernal 306, Betancur 2818, Forero 7370) from higher elevations on the western slopes of the Western Cordillera appear intermediate between this subspecies and G. interrupta subsp. magnifica, and may represent hybrids. They have the flower pits densely hairy internally distally only, as in G. interrupta.
description: Published as part of Henderson, Andrew, 2011, A revision of Geonoma (Arecaceae), pp. 1-271 in Phytotaxa 17 on page 122, DOI: 10.11646/phytotaxa.17.1, http://zenodo.org/record/3538362
ABC News/Washington Post Poll # 1987-7307: Bork Vote Poll Bork Vote Poll
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2008

description: Robert Bork as Supreme Court nominee (4); Bork hearings (3); Senate's consideration on Bork nomination (2); pro/anti Bork activities (4); influence of certain groups and individuals on Bork nomination (8).
title: Who Cares?
Creators: name: Schweder, Verena
Year: 2020

description: Die Sicherstellung der Pflege zählt zu den größten Herausforderungen unserer Zeit. Aufgrund der demographischen Entwicklung, die sich in sinkender Geburtenrate und steigender Lebenserwartung ausdrückt, werden in Österreich bis 2030 rund 75.000 zusätzliche Pflegekräfte benötigt. Doch die Pflegearbeit ist durch schwierige Arbeitsbedingungen sowie mangelnde gesellschaftliche und finanzielle Anerkennung ein unattraktiver Beruf. Experten sind sich einig, dass eine finanzielle Aufwertung ein wichtiger Schritt wäre, um den Pflegeberuf attraktiveren zu machen und die PflegerInnen im Beruf zu halten. Diverse Analysen belegen, dass Pflegekräfte in Österreich wenig verdienen. Hingegen existiert keine Studie, die prüft, ob Pflegekräfte im Verhältnis zu ihren Arbeitsbedingungen gerecht entlohnt werden. Vor diesem Hintergrund wird untersucht, ob Pflegekräfte bei einer geschlechtsneutralen Arbeitsbewertungsmethode gemäß ihrer Arbeitsanforderungen bzw. -belastungen entlohnt werden. Dafür wurde das Messinstrument Comparable Worth-Index verwendet, um die Anforderungen und Belastungen der österreichischen Pflegeberufe zu messen. Im nächsten Schritt wurden die Verdienste der Pflegeberufe mit jenen von anderen Berufen verglichen, die gleichwertige Arbeitsbedingungen verzeichnen. Die Ergebnisse zeigen, dass die österreichischen Pflegeberufe nicht entsprechend ihrer beruflichen Anforderungen und Belastungen entlohnt werden. Denn gemessen an einer geschlechtsneutralen Arbeitsbewertungsmethode müssten die Verdienste der Pflegeberufe deutlich höher ausfallen. Dabei ist die Verdienstlücke zu gleichwertigen Berufen in den höheren Pflegeausbildungsstufen besonders groß.
Professor Emil Julian Chibowski, Ph.D., D.Sc. A tribute on his 50th year of scientific activity
Creators: name: Holysz, Lucyna
name: Janusz, Wladyslaw
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2016
Subjects: Emil Julian Chibowski

description: Physicochemical Problems of Mineral Processing; ISSN 2084-4735
Additional file 1 of Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study
Creators: name: Wong, Kai On
name: Klarenbach, Scott W.
name: Martins, Karen J. B.
name: Chue, Pierre
name: Dursun, Serdar M.
name: Snaterse, Mark
name: Guigue, Alexis
name: So, Helen
name: Luu, Huong
name: Vu, Khanh
name: Richer, Lawrence
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Diagnostic codes used within the schizophrenia case finding algorithm.
Additional file 2 of Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study
Creators: name: Wong, Kai On
name: Klarenbach, Scott W.
name: Martins, Karen J. B.
name: Chue, Pierre
name: Dursun, Serdar M.
name: Snaterse, Mark
name: Guigue, Alexis
name: So, Helen
name: Luu, Huong
name: Vu, Khanh
name: Richer, Lawrence
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Identification of oral and long-acting injectable antipsychotics based on anatomical therapeutic chemical classification and/or drug identification number.
Gallup Special # 1988-88215: Changing Public Attitudes on Governments and Taxes, 1988
Creators: name: Relations, The Advisory Commission On Intergovernmental
Publisher: name: Roper Center for Public Opinion Research
Year: 1989

description: Taxes(3); opinion of local/state/federal government(3); use of public funds to promote foreign trade(3); public works services(4); state constitution/bill of rights(2).
title: Polyphonie des Ghettos
Creators: name: Faerber, Sigfrid
Year: 2020

description: Die "Cultur-Bilder aus dem jüdischen Leben in Galizien" gelten als einige der letzten Höhepunkte gegen Ende der deutsch-jüdischen Literaturperiode in Osteuropa, die von sogenannten Ghettogeschichten dominiert war. Nathan Samuely (1847–1921) versammelte in den beiden Bänden seiner Cultur-Bilder in den Jahren 1885 und 1892 insgesamt 45 solcher kurzen Erzählungen; einige davon waren zuvor schon mit Erfolg beim Leserpublikum und mit guter Kritik in jüdischen Zeitschriften auf deutsch erschienen. Seinen Namen hatte er sich schon während der Schulzeit gemacht mit Lyrik zu Figuren und Ereignissen aus der biblischen Geschichte. Aus dem südgalizischen Stryj stammend, arbeitete er nach der Schule als Lehrer an der Israelitischen Normalschule in Lemberg und danach als Schriftsteller und freier Journalist. Nach der Jahrhundertwende übersiedelte er nach Österreich und starb dann in Baden bei Wien, wo er auf dem jüdischen Friedhof begraben liegt. Einige seiner Texte sind verschollen und nur dem Titel nach bekannt. In den Texten seiner Cultur-Bilder wird Samuelys aufklärerische, liberal fortschrittliche und kritische Gesinnung deutlich, mit der er als Anhänger der Haskala damals in Opposition zur Mehrheit der zeitgenössischen orthodoxen und chassidischen Judenschaft Galiziens stand. Als Autor-Erzähler entwickelte er dabei eine nostalgisch affirmative, didaktische und kritische, oft auch ironische Erzählhaltung, mit der er die untergehende Schtetl-Kultur noch einmal aufleben ließ – manchmal mit warmem Humor und immer mit großer Empathie gegenüber ihren kleinen und größeren Helden. Umrahmt von knappen Schilderungen der wesentlichen sozialen, kulturellen und politischen Kontexte bieten auf diesen Seiten die kurzen Analysen von fünf ausgewählten Geschichten einen Aussschnitt aus der thematischen, narrativen und textlichen Vielfalt seiner Cultur-Bilder. Sie zeigen zugleich Beispiele für Samuelys autobiographisch gefärbte jüdische Memoria, mit der er seinen eigenen Ruf nach Selbstbestimmung dokumentierte.
Geonoma pinnatifrons subsp. vaga Henderson
Creators: name: Henderson, Andrew
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Arecales
Arecaceae
Geonoma
Geonoma pinnatifrons
Geonoma pinnatifrons subsp. vaga (grisebach & wendland in grisebach) henderson

description: 49i. Geonoma pinnatifrons subsp. vaga (Grisebach & Wendland in Grisebach) Henderson, comb. & stat. nov.
Basionym: Geonoma vaga Grisebach & Wendland in Grisebach (1864: 517). Geonoma saga Spruce (1871: 109), orth. var. Geonoma pinnatifrons Willdenow var. vaga (Grisebach. & Wendland) Burret (1930a: 246). Lectotype (here designated): TRINIDAD & TOBAGO. Trinidad: Mount Tamana, 28 April 1841, W. Purdie 23 (lectotype K!).
Leaf pinnae per side of rachis no data. Inflorescences peduncular bracts inserted 1.5(0.7–2.5) cm above the prophyll; peduncles 22.6(13.0–37.0) cm long, 5.8(4.0–11.0) mm in diameter; rachillae 12.4(8.4–18.9) cm long, 2.3(1.7–3.0) mm in diameter; fruits 5.5(5.0–6.0) mm in diameter.
Distribution and habitat:— From 10°38’– 11°18’N and 60°34’– 63°10’W on the Península de Paria, Venezuela, the Northern Range, Trinidad, and Tobago at 740(400–900) m elevation in lowland rainforest (Fig. 33).
Although there is geographic discontinuity there are too few specimens and too many missing data to test for differences amongst areas.
description: Published as part of Henderson, Andrew, 2011, A revision of Geonoma (Arecaceae), pp. 1-271 in Phytotaxa 17 on page 122, DOI: 10.11646/phytotaxa.17.1, http://zenodo.org/record/3538362
Additional file 3 of Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study
Creators: name: Wong, Kai On
name: Klarenbach, Scott W.
name: Martins, Karen J. B.
name: Chue, Pierre
name: Dursun, Serdar M.
name: Snaterse, Mark
name: Guigue, Alexis
name: So, Helen
name: Luu, Huong
name: Vu, Khanh
name: Richer, Lawrence
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Antipsychotic medication use and mean possession ratio among the CTO cohorts.
Associated Press/Ipsos Public Affairs: Presidential Election/Finances
Creators: name: Associated Press
Publisher: name: Roper Center for Public Opinion Research
Year: 2009

description: Direction of country (1); George W. Bush job performance (2); George W. Bush handling issues (8); presidential preference (4); party for Congress (1); economic conditions (2); financial situation (3); making purchases (2); job market (3); investing (1); describing George W. Bush (7); describing John Kerry (7); candidates inspiring optimism (1).
Additional file 1 of Association between lipid profiles and viral respiratory infections in human sputum samples
Creators: name: Humes, Sara T.
name: Iovine, Nicole
name: Prins, Cindy
name: Garrett, Timothy J.
name: Lednicky, John A.
name: Coker, Eric S.
name: Sabo-Attwood, Tara
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Table S1. Optimization of the BioFire FilmArray® platform for sputum samples. Table S2. Concordance of pathogen identification between nasalpharyngeal (NP) swab and sputum samples. Table S3. Number of lipids identified in each class and percent of total lipids for positive and negative mode. Figure S1. Causal diagram, also known as directed acyclic graph (DAG), that presents a visualization of the other variables that may play a role in the relationship between lung lipids (exposure) and viral respiratory infection (outcome). Figure S2. Intensity of all lipids identified in the positive (S1A) and negative (S1B) modes.
Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics
Creators: name: Bhasin, Sidharth
name: Das, Asmita
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: SHP1 is a protein tyrosine phosphatase playing a central role in immunity, cell growth, development, and survival. The inhibition of SHP1 can help in better prognosis in various disorders like breast and ovarian cancer, melanoma, atherosclerosis, hypoxia, hypoactive immune response, and familial dysautonomia. The currently available inhibitors of SHP1 have the side effect of inhibiting the activity of SHP2, which shares >60% sequence similarity with SHP1 but has distinct biological functions. Thus, there is a need to search for novel specific inhibitors of SHP1. The current study uses a combination of virtual screening and molecular dynamic simulations, followed by PCA and MM-GBSA analysis, to screen about 35000 compounds; to predict that two rigidin analogues can potentially selectively inhibit SHP1 but not SHP2. Our studies demonstrate that these rigidin analogues are more potent at inhibiting SHP1 than the commercially available inhibitor NSC-87877. Further, cross-binding studies with SHP2 exhibited poor binding efficiency and lower stability of the complex, thus indicating a specificity of the rigidin analogues for SHP1, which is crucial in preventing side effects due to the diverse physiological functions of SHP2 in cellular signaling, proliferation, and hematopoiesis. Additionally, SHP1 is essential in mediating the inhibitory signaling in antitumor immune cells like NK and T cells. Hence, the rigidin analogues that inhibit SHP1 will potentiate the anti-tumor immune response by the release of inhibitory function of NK cells, thus driving NK activating response, in addition to their intrinsic anti-tumor function. Thus, SHP1 inhibition is a novel double-blade approach towards anti-cancer immunotherapeutics. Communicated by Ramaswamy H. Sarma
Additional file 1 of miRglmm: a generalized linear mixed model of isomiR-level counts improves estimation of miRNA-level differential expression and uncovers variable differential expression between isomiRs
Creators: name: Baran, Andrea M.
name: Patil, Arun H.
name: Aparicio-Puerta, Ernesto
name: Jun, Seong-Hwan
name: Halushka, Marc K.
name: McCall, Matthew N.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional File 1: Supplemental figures and tables
Luntz Survey: Drug Attitudes: Teens and Adults
Creators: name: Addiction, The National Center On
Publisher: name: Roper Center for Public Opinion Research
Year: 2010

description: TEEN SURVEY: Most important problem (1); economic opportunities (1); smoke cigarettes (5); alcohol (9); marijuana (9); illegal drugs (18); tobacco/drug/alcohol addiction (4); drug selling (1); anti-drug program (1); legalization of marijuana/drugs (2); ,media encouraging illegal drug use (2); source of information (4); employment (1); hobbies (1); family (1); parents work (2); religion (2); grades in school (1). ADULT SURVEY: Most important problem (1); AIDS (1); illegal drugs (14); morality in US (1); smoke cigarettes (8); marijuana (9); alcohol (6); cigarette/drug/alcohol addictions (9); anti-drug program (4); legalization of marijuana/drugs (2); drug laws (1); media encouraging illegal drug use (3); community efforts in anti-drug program (1); children interaction with drugs (1); source of information (6).
Additional file 4 of Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study
Creators: name: Wong, Kai On
name: Klarenbach, Scott W.
name: Martins, Karen J. B.
name: Chue, Pierre
name: Dursun, Serdar M.
name: Snaterse, Mark
name: Guigue, Alexis
name: So, Helen
name: Luu, Huong
name: Vu, Khanh
name: Richer, Lawrence
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Healthcare resource utilization during the pre- and post-index periods among the CTO cohorts.
Insights into the dynamic interactions of RNase a and osmolytes through computational approaches
Creators: name: Ilyas, Ashal
name: Poddar, Nitesh Kumar
name: Borkotoky, Subhomoi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Molecular Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Computational Biology

description: Osmolytes are small organic molecules that are known to stabilize proteins and other biological macromolecules under various stressful conditions. They belong to various categories such as amino acids, methylamines, and polyols. These substances are commonly known as ‘compatible solutes’ because they do not disrupt cellular processes and help regulate the osmotic balance within cells. In the case of ribonuclease A (RNase A), which is prone to aggregation, the presence of osmolytes can help to maintain its structural stability and prevent unwanted interactions leading to protein aggregation. In this study, we investigated the interaction between RNase A and several osmolytes using molecular docking and molecular dynamics (MD) simulations. We performed molecular docking to predict the binding mode and binding affinity of each osmolyte with RNase A. MD simulations were then carried out to investigate the dynamics and stability of the RNase A-osmolyte complexes. Our results show that two osmolytes, glucosylglycerol and sucrose have favorable binding affinities with RNase A. The possible role of these osmolytes in stabilizing the RNase A and prevention of aggregation is also explored. By providing computational insights into the interaction between RNase A and osmolytes, the study offers valuable information that could aid in comprehending the mechanisms by which osmolytes protect proteins and help in designing therapeutics for protein-related disorders based on osmolytes. These findings may have significant implications for the development of novel strategies aimed at preventing protein misfolding and aggregation in diverse disease conditions. Communicated by Ramaswamy H. Sarma
Additional file 5 of Health resource utilization and cost before versus after initiation of second-generation long-acting injectable antipsychotics among adults with schizophrenia in Alberta, Canada: a retrospective, observational single-arm study
Creators: name: Wong, Kai On
name: Klarenbach, Scott W.
name: Martins, Karen J. B.
name: Chue, Pierre
name: Dursun, Serdar M.
name: Snaterse, Mark
name: Guigue, Alexis
name: So, Helen
name: Luu, Huong
name: Vu, Khanh
name: Richer, Lawrence
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5. Median healthcare costs during the pre- and post-index periods among the overall and CTO cohorts.
NBC/WSJ Poll # 2006-6063: Economy/Congress/Immigration/Iraq/Global Warming
Creators: name: NBC News
name: Wall Street Journal
Publisher: name: Roper Center for Public Opinion Research
Year: 2007

description: Direction of the country (1); George W. Bush job performance (4); Congress job performance (1); feelings towards public figures/organizations (9); 2006 Congressional elections (7); top priority issues for federal government to address (2); likeliness of voting for Congressional candidate taking certain positions (10); views/concerns on political parties' control of Congress (2); investigation of Bush administration actions (3); political party that would do a better job of handling issues (17); ethical problems of present Congress members (1); influence of political parties by special interest/lobbyists (1); concerns about the political parties (2); economy (4); immigration (4); war in Iraq (12); climate change/global warming (1); vote in 2004 Presidential elections (1).
title: Noblesse oblige?
Creators: name: Zettl, Joachim
Year: 2020

description: Die Armee des Hauses Habsburg war im 18. Jahrhundert noch Teil der Streitkräfte des Heiligen Römischen Reiches Deutscher Nation. Dementsprechend war sie weit davon entfernt, eine rein „österreichische Armee“ zu sein. Die Soldaten kamen aus verschiedensten Teilen Europas und die Kriegsführung in diesem Jahrhundert stellte die Heeresleitung vor immer neue Herausforderungen. Ein Schlüsselelement in jeder Armee zur Bewältigung dieser Herausforderungen waren die Offiziere, die eine gewisse Schnittmenge mit dem europäischen Adel aufwiesen. Diese Arbeit geht der Frage nach wie der Adel sich in die militärischen Strukturen, spezifisch in das Offizierskorps der österreichischen Infanterie, in der Mitte des Jahrhunderts, um genau zu sein in der Übergangszeit von Karl VI zu Maria Theresia einfügte, also aus welchen Regionen und Adelsschichten sie stammten, welche Aufgaben und Vorraussetzungen sie zu erfüllen hatten und wie sie sich in die Gesellschaft, wie auch das Militär des Reiches einfügten. Zu diesem Zweck sollen statistische Erkenntnisse die aus Musterlisten gewonnen werden mit dem gegenwärtigen militär- und adelsgeschichtlichen Forschungsstand abgeglichen und daraus eine Analyse des Adels im österreichischen Offizierskorps erstellt werden.
description: The army of house Habsburg in the 18th century still has been part of the Holy Roman Empire. According to that, it wasn’t yet a pure “Austrian” army. The soldiers came from different regions of Europe and warfare in this century contained multiple challenges for the military command. Key elements, to overcome these challenges, were the officers, which showed a certain overlap with European nobility. This Thesis is intended, to focus on the question, how nobility fit into the military structures, specifically into the officer-corps of the Austrian infantry, in the middle of the century, more specifically in the transition period from Charles VI to Mary-Therese, from which regions and noble classes they originated and how they fit into the society and also into the military of the empire. To this end, statistic cognitions, gained from specimen lists, shall be compared to the current state of research about military- and noble-history and from that an analysis about nobility in the Austrian officer-corps shall be compiled.
VRS State Primary Exit Poll: Massachusetts Republican Primary
Creators: name: ABC News
name: CBS News
name: CNN
name: NBC News
Publisher: name: Roper Center for Public Opinion Research
Year: 1993

description: Voting record(2); most important issue(1); candidates issues(6); voting intentions(2); national issues(1); government performance(1); ideology (1); party ID(1); economic situation(2); president job approval(1).
USIA Poll # 1994-I94057: Economic Health/Government Policies/Drug Trafficking/EEUU
Creators: name: USIA
Publisher: name: Roper Center for Public Opinion Research
Year: 2007

description: Employment (6); most important problems (2); economy (1); media (4); consumerism/trade (4); illegal drugs (6); politics (5); institutions/organizations job performance (8); corruption (1); foreign relations (2); EEUU (7).
Additional file 1 of Willingness to pay for a second pair of near-vision glasses: a cross-sectional study in a rural North Indian population
Creators: name: Sabherwal, Shalinder
name: Nayab, Javed
name: Mazumdar, Atanu
name: Thaker, Nam
name: Javed, Mohd
name: Nathawat, Rakhi
name: Bastawrous, Andrew
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1.
Additional file 2 of Effect of introducing interprofessional education concepts on students of various healthcare disciplines: a pre-post study in the United Arab Emirates
Creators: name: Zaher, Shroque
name: Otaki, Farah
name: Zary, Nabil
name: Al Marzouqi, Amina
name: Radhakrishnan, Rajan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2.
ABC News/The Washington Post Poll # 1981-875602: Race Relations
Creators: name: ABC News
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 1986

description: most important problem of country (1); neighborhoods (5); personal friend (1); children in household (2); public schools (1); anti-Black feeling (2); anti-Jewish feeling (2); violent protests (2); general housing issue (1); Ku Klux Klan (2); lifestyle of Blacks (3); different issues to agree or disagree with (1); Reagan administration vs. Carter administration for Blacks (1); Black people victims (2); Black discrimination (1); immigration (1); immigrants from Vietnam (1); immigrants from Cuba (1); working immigrants (1); sex education in school (1); being a victim (2); guns (3); nation's economy (2); religion (2).
Imaging of Aneurysmal bone Cyst (ABC) of the tibia with brief review of literature
Creators: name: Mathew, Rishi
Publisher: name: EURORAD
Year: 2016
Subjects: subject: Abdomen
subject: Musculoskeletal bone
subject: Catheter arteriography
subject: Conventional radiography
subject: MR
subject: Plain radiographic studies
subject: Diagnostic procedure
subject: Neoplasia

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 21 years
description: Clinical History: A 21 year old female patient presented with swelling near the right knee and associated mild pain for 2 months. She was treated in another hospital one year previously for trauma in the same region. No previous images were available for comparison. Final Diagnosis: Aneurysmal Bone Cyst of the Right Tibia
Umbelliferone modulates the quorum sensing and biofilm of Gram − ve bacteria: in vitro and in silico investigations
Creators: name: Qais, Faizan Abul
name: Ahmad, Iqbal
name: Husain, Fohad Mabood
name: Arshad, Mohammed
name: Khan, Altaf
name: Adil, Mohd
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: In last two decades, the world has seen an exponential increase in the antimicrobial resistance (AMR), making the issue a serious threat to human health. The mortality caused by AMR is one of the leading causes of human death worldwide. Till the end of the twentieth century, a tremendous success in the discovery of new antibiotics was seen, but in last two decades, there is negligible progress in this direction. The increase in AMR combined with slow progress of antibiotic drug discovery has created an urgent demand to search for newer methods of intervention to combat infectious diseases. One of such approach is to look for biofilm and quorum sensing (QS) inhibitors. Plants are excellent source of wide class compounds that can be harnessed to look for the compounds with such properties. This study proves a broad-spectrum biofilm and QS inhibitory potential of umbelliferone. More than 85% reduction in violacein production Chromobacterium violaceum 12472 was found. All tested virulent traits of Pseudomonas aeruginosa PAO1 and Serratia marcescens MTCC 97 were remarkably inhibited that ranged from 56.62% to 86.24%. Umbelliferone also successfully prevented the biofilm of test bacteria at least by 67.68%. Umbelliferone interacted at the active site of many proteins of QS circuit, which led to the mitigation of virulent traits. The stable nature of complexes of umbelliferone with proteins further strengthens in vitro results. After examining the toxicological profile and other drug-like properties, umbelliferone could be potentially developed as new drug to target the infections caused by Gram − ve bacteria. Communicated by Ramaswamy H. Sarma
Additional file 2 of miRglmm: a generalized linear mixed model of isomiR-level counts improves estimation of miRNA-level differential expression and uncovers variable differential expression between isomiRs
Creators: name: Baran, Andrea M.
name: Patil, Arun H.
name: Aparicio-Puerta, Ernesto
name: Jun, Seong-Hwan
name: Halushka, Marc K.
name: McCall, Matthew N.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional File 2: miRglmm software package vignette
Design, synthesis and docking studies of novel 4-aminophenol-1,2,4-oxadiazole hybrids as apoptosis inducers against triple negative breast cancer cells targeting MAP kinase
Creators: name: Dhanalakshmi, Boregowda
name: Kumar, Belagal Motatis Anil
name: Murthy, Venkatappan Srinivasa
name: Srinivasa, Sudhanva Muddenahalli
name: Vivek, Hamse Kameshwar
name: Sennappan, Madhappan
name: Rangappa, Shobith
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: In our study, a series of novel 4-aminophenol benzamide-1,2,4-oxadiazole hybrid analogues have been designed and synthesized by condensing 4-hydroxyphenyl arylamides (3a–c) and 5-chloromethyl-3-aryl-1,2,4-oxadiazoles (6a–d). The structure of the synthesised compounds was verified by various spectroscopic techniques (1H NMR, 13C NMR, IR and LC-MS). All the prepared compounds were subjected to in silico and in vitro antiproliferative study against TNBC cell lines MDA-MB-468 and MDA-MB-231. The investigations revealed that compound 7k significantly promoted apoptosis against MDA-MB-468 and MDA-MB-231 cells with IC50 values of 22.31 µM and 26.27 µM, respectively. Compound 7k interacted with crucial active sites of MAPK and exhibited the highest docking score of −7.06 kcal/mol. Docking was validated with molecular dynamic studies with simulation for 100 ns, depicting various stable interactions with MAPK. Consequently, 7k forms stable H-Bonds and π-π stacking with amino acid residues along with π-cation. Our investigations reveal that the in vitro antiproliferative study of 7k was in good correlation with the in silico studies. Hence, 7k serves as a potential novel lead for the inhibition of TNBCs by downregulating MAPK P38. Communicated by Ramaswamy H. Sarma Novel 4-aminophenol benzamide-1,2,4 oxadiazole library of small molecules displayed potent antiproliferative activity.Compound 7k induces apoptosis significantly against triple-negative breast cancer cells.Compound 7k potentiates apoptosis by targeting MAPK P38 and altering mitochondrial membrane potential.Molecular docking and molecular dynamic simulations confirm the efficient binding of compound 7k with MAPK (Docking score of –7.06 kcal/mol). Novel 4-aminophenol benzamide-1,2,4 oxadiazole library of small molecules displayed potent antiproliferative activity. Compound 7k induces apoptosis significantly against triple-negative breast cancer cells. Compound 7k potentiates apoptosis by targeting MAPK P38 and altering mitochondrial membrane potential. Molecular docking and molecular dynamic simulations confirm the efficient binding of compound 7k with MAPK (Docking score of –7.06 kcal/mol).
FLASHForward‣‣ into the Future - Challenges and Prospects for Plasma-Wave Acceleration
Creators: name: Osterhoff, Jens
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017

description: SFB 676 Colloquium, Hamburg, University Hamburg, Germany, 25 Jan 2017 - 25 Jan 2017
ASQC/Gallup Poll # 1988-88064: Public Opinion on the Quality of American Products
Creators: name: American Society For Quality Control
Publisher: name: Roper Center for Public Opinion Research
Year: 2013

description: Concerns about government (3); quality of some government services (2); determination of product quality (10); companies associated with quality (1); American quality rating, now and in the future (2); handling poor quality and contact with the manufacturer (10); determination of the quality of services (1); quality of specific service industries (7); responsiveness of companies (3).
Supplementary Figures 1-8 and Tables 1-7 from A personal cost of cheating can stabilize reproductive altruism during the early evolution of clonal multicellularity
Creators: name: Cameron-Pack, Marybelle E.
name: König, Stephan G.
name: Reyes-Guevara, Anajose
name: Reyes-Prieto, Adrian
name: Nedelcu, Aurora M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Additional images, tables and information regarding the mutants and their sensitivity to stress
Additional file 1 of Effect of introducing interprofessional education concepts on students of various healthcare disciplines: a pre-post study in the United Arab Emirates
Creators: name: Zaher, Shroque
name: Otaki, Farah
name: Zary, Nabil
name: Al Marzouqi, Amina
name: Radhakrishnan, Rajan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Electron Beam Characterization for Generating THz Radiation with PITZ
Creators: name: Boonpornprasert, P.
name: Chen, Ye Lining
name: Good, J.
name: Huck, H.
name: Isaev, I.
name: Kalantaryan, D.
name: Krasilnikov, M.
name: Li, Xin
name: Lishilin, O.
name: Loisch, G.
name: Melkumyan, D.
name: Oppelt, A.
name: Qian, H.
name: Renier, Y.
name: Rublack, T.
name: Stephan, F.
name: Zhao, Quantang
name: Asova, G.
name: Saisa-Ard, C.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017

description: 3nd Annual MT Meeting, Darmstadt, Germany, 31 Jan 2017 - 2 Feb 2017
Bioactive compounds derived from marine source: a potential immunotherapy treatment
Creators: name: Jabeen, Yaruq
name: Yousaf, Numan
name: Sarjadi, Mohd Sani
name: Gansau, Jualang Azlan
name: Goh, Lucky Poh Wah
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Immunotherapy using checkpoint inhibitors blocks the checkpoint proteins (programmed cell death receptor-1; PD-1) from binding with their corresponding ligands (programmed cell death receptor ligand-1; PD-L1) to regulate cell signaling pathways. The marine environment holds a huge source of small molecules that are understudied which can be developed as an inhibitor. Hence, this study investigated the inhibitory effect of 19 algae-derived small molecules against PD-L1 by using molecular docking, absorption, distribution, metabolism, and elimination (ADME) properties and molecular dynamics simulations (MDS). The molecular docking revealed that the binding energy of the six best compounds ranges from −11.1 to −9.1 kcal/mol. Fucoxanthinol, in particular, has the strongest binding energy at −11.1 kcal/mol with three hydrogen bonds (ASN:63A, GLN:66A, and ASP:122A). Meanwhile, the MDS demonstrated that the ligands were strongly bound to the protein, indicating the stability of the complexes. In summary, the identified compounds are potential PD-L1 inhibitors in immunotherapy. Communicated by Ramaswamy H. Sarma
Gallup Special # 1988-GIVE: Survey on Giving and Volunteering
Creators: name: Sector, The Independent
Publisher: name: Roper Center for Public Opinion Research
Year: 1989

description: Importance of various personal goals(10); personal financial situation (3); role of government(7); role of charities(5); confidence in various institutions(12); volunteer work performed in last year(7); volunteer work performed in past month(2); current volunteer activities(3); change in volunteer activities(4); involvement in community(2); contributions of money/property(5); reasons for giving to charity(2); timing of religious charitable contributions(6); change in contributions(6); means of soliciting charitable contributions(8); income tax deductions (5); method of contributing to charitable causes(2); GIVE FIVE campaign (2).
Determination of antioxidant, DNA protection, enzyme inhibition potential and molecular docking studies of a biomarker ursolic acid in Nepeta species
Creators: name: Yenigün, Semiha
name: Başar, Yunus
name: İpek, Yaşar
name: Behçet, Lütfi
name: Özen, Tevfik
name: Demirtaş, İbrahim
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Ursolic acid (UA), which has many biological properties such as anti-cancer, anti-inflammatory and antioxidant, and regulates some pharmacological processes, has been isolated from the flowers, leaves, berries and fruits of many plant species. In this work, UA was purified from the methanol-chloroform crude extract of Nepeta species (N. aristata, N. baytopii, N. italica, N. trachonitica, N. stenantha) using a silica gel column with chloroform or ethyl acetate solvents via bioactivity-guided isolation. The most active sub-fractions were determined under bioactivities using antioxidant and DNA protection activities and enzyme inhibitions. UA was purified from these fractions and its structure was elucidated by NMR spectroscopy techniques. The highest amount of UA was found in N. stenantha (8.53 mg UA/g), while the lowest amount of UA was found in N. trachonitica (1.92 mg UA/g). The bioactivities of UA were evaluated with antioxidant and DNA protection activities, enzyme inhibitions, kinetics and interactions. The inhibition values (IC50) of α-amylase, α-glucosidase, urease, CA, tyrosinase, lipase, AChE, and BChE were determined between 5.08 and 181.96 µM. In contrast, Ki values of enzyme inhibition kinetics were observed between 0.04 and 0.20 mM. In addition, Ki values of these enzymes for enzyme-UA interactions were calculated as 0.38, 0.86, 0.45, 1.01, 0.23, 0.41, 0.01 and 2.24 µM, respectively. It is supported that UA can be widely used as a good antioxidant against oxidative damage, an effective DNA protector against genetic diseases, and a suitable inhibitor for metabolizing enzymes. Communicated by Ramaswamy H. Sarma
Project Safeshore: "Drone-Vs-Bird Detection Challenge"
Creators: name: Coluccia, Angelo
Publisher: name: Zenodo
Year: 2017

description: The SafeShore Consortium promoted a dedicated international workshop called “WOSDETC” (http://wosdetc.wordpress.com) within the 14th edition of the IEEE International Conference on Advanced Video and Signal based Surveillance (AVSS, http://www.avss2017.org), held in Lecce, Italy, from August 29th to September 1st, 2017. In particular, about 20 different groups from all over the world joined the “Drone-vs-Bird Detection Challenge”, a competition launched by the SafeShore Consortium to award the most effective algorithm able to automatically discriminate between RPAS and their much look-alike natural counterpart, that is, birds, under change of light conditions, moving camera, weak contrast, and other unfavorable factors found in real environments.

The different results haven been presented at WOSDETC. The winner has been awarded with a high-performance platform for video analytics offered by Nvidia, sponsor of WOSDETC and AVSS.
Targeting α-amylase enzyme through multi-fold structure-based virtual screening and molecular dynamic simulation
Creators: name: Halim, Sobia Ahsan
name: Lodhi, Hamayal Wajid
name: Waqas, Muhammad
name: Khalid, Asaad
name: Abdalla, Ashraf N.
name: Khan, Ajmal
name: Al-Harrasi, Ahmed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: α-Amylase play important role in hydrolyses of α-bonds of large α-linked polysaccharides; thus, it is a potential drug target in diabetes mellites (DM) and its inhibition is one of the therapeutic strategies in DM. With the aim to discover novel and safer therapeutic molecules to combat diabetes, a huge dataset of ∼0.69 billion compounds from ZINC20 database were screened against α-amylase using multi-fold structure-based virtual screening protocol. Based on receptor-based pharmacophore model, docking results, pharmacokinetic profile, molecular interactions with α-amylase, several compounds were retrieved as lead candidates to be further scrutinized in the in vitro assay and in vivo animal testing. Among the selected hits, CP26 exhibited the highest binding free energy in MMGB-SA analysis, followed by CP7 and CP9, which is higher than the binding free energy of acarbose. While CP20 and CP21 showed comparative binding free energy to acarbose. All the selected ligands showed acceptable binding energy range, therefore, several molecules with enhanced efficacy can be designed by derivatizing these molecules. The in-silico results indicates that the selected molecules could serve as potential selective α-amylase inhibitors and can be used for the treatment of diabetes. Communicated by Ramaswamy H. Sarma
Los Angeles Times/Bloomberg News Poll: Politics and the Economy
Creators: name: Bloomberg News
Publisher: name: Roper Center for Public Opinion Research
Year: 2008

description: Direction of country (1); voter registration (1); presidential primary (3); Democratic candidates (5); super delegates (1); votes of Michigan and Florida (1); John McCain (4); 2008 presidential election (3); priorities for candidates (1); leadership (2); handling economy (2); handling healthcare (2); handling taxes (2); experience to be president (2); honesty and integrity (2); change Washington (2); handling illegal immigration situation (2); handling Iraq (2); protecting country from terrorism (2); handling economy (1); Hillary Clinton (1); Barack Obama (1); age of president (1); country readiness for woman president (1); country readiness for black president (1); George W. Bush (1); national economy (2); economic recession (1); start economic growth (1); economic stimulus package (2); Bush administration aid to housing industry (1); sub-prime mortgages (1); healthcare reform (1); increase taxes to provide health insurance (1); situation in Iraq (1).
Additional file 2 of Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model
Creators: name: Freitag, Kiara
name: Sterczyk, Nele
name: Wendlinger, Sarah
name: Obermayer, Benedikt
name: Schulz, Julia
name: Farztdinov, Vadim
name: Mülleder, Michael
name: Ralser, Markus
name: Houtman, Judith
name: Fleck, Lara
name: Braeuning, Caroline
name: Sansevrino, Roberto
name: Hoffmann, Christian
name: Milovanovic, Dragomir
name: Sigrist, Stephan J.
name: Conrad, Thomas
name: Beule, Dieter
name: Heppner, Frank L.
name: Jendrach, Marina
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 2. Supplementary methods.