cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Budget impact analysis of Jivi (damoctocog alfa pegol, Bay 94-9027) in severe hemophilia A in Japan
Creators: name: Teruhisa Fujii
name: Kidoguchi, Yuko
name: Takahashi, Noriko
name: Yu, Eric
name: Dilinuer Ainiwaer
name: Byrne, Aidan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Hemophilia A (HA) is a genetic bleeding disorder characterized by a deficiency of clotting factor VIII (FVIII) requiring lifelong prophylactic treatment typically with conventional standard half-life recombinant FVIII (rFVIII). Lifelong prophylaxis impacts budget, patient adherence, and long-term outcomes. The consequent economic and treatment burden may be reduced by using novel extended half-life rFVIII. The objective of this analysis was to estimate the budget impact of introducing Jivi (damoctocog alfa pegol, BAY 94-9027), hereafter referred to as BAY 94-9027, as an on-demand and prophylactic treatment for severe HA from a Japanese payer’s perspective. A global budget impact model was adapted to the Japanese setting using data obtained via a targeted literature review of Japanese sources. The model considered a five-year time horizon for a market without and with BAY 94-9027. Using annual per-patient costs, the total cost of on-demand and prophylactic treatment of adolescent and adult patients with severe HA (without inhibitors) were analyzed. The model used summary of product characteristics (SmPC) and clinical trial dosing, and unit costs from the National Health Insurance (NHI) drug price database. Comparators considered in the model comprised of currently available products in Japan. Projected BAY 94-9027 uptake ranged from 4% to 9% over the five years (2020–2024). Introduction of BAY 94-9027 for the treatment of severe HA is estimated to decrease the overall budget by 1.5%, with a cost saving of approximately $67 million USD (¥7.4 billion JPY) over five years. Estimated cost savings associated with BAY 94-9027 ranged from $1.4 million USD (¥156 million JPY) in 2020 to $23 million USD (¥2.6 billion JPY) in 2024 for the Japanese healthcare system. There were limitations associated with the study. The Japanese guidelines consulted during the targeted literature review of national data sources in Japan were based on global data as reference sources. Also, studies reporting the bleeding rate, dosing guidelines, and economic burden in the Japanese population identified by the targeted literature review were limited hence global studies were used and may not have been representative of the Japanese population. BAY 94-9027 can reduce total severe HA treatment costs, driven by lower annual rFVIII utilization, and a narrow weekly dosing range compared to competitor products in the Japanese market.
Patterns that Grow
Creators: name: Bruno, William J.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Chemotactic bacteria have been observed to congregate into highly regular patterns. When the bacteria are placed in the center of a dish, a wave of bacteria can travel outward, leaving a regular pattern of spots or stripes in its wake. Although chemotaxis and excretion of an attractant can readily cause a pattern forming instability from a uniform state, they are not capable of generating patterns starting from a single spot. These patterns are apparently formed with the help of bacterial growth and depletion of nutrients in the growth medium.
description: Prominently-cited and requested but not previously available on-line article
Enhanced flotation of Pb(II)-activated wolframite using a novel collector
Creators: name: Qi, Jing
name: Liu, Sheng
name: Qiu, Xianyang
name: Liu, Guangyi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: The flotation enrichment of fine-particle wolframite played a crucial role in production of strategic key metal tungsten. In this paper, N-[(3-hydroxyamino)-propoxy]-N-hexyl dithiocarbamate (HAHD) was designed to strengthen the flotation recovery of wolframite. The in situ AFM images clearly exhibited that the pre-activation of wolframite with Pb2+ ions significantly enhanced the self-assemble and aggregation of HAHD on its surface, and its surface hydrophobicity and floatability dramatically improved. The FTIR and XPS results recommended a chemisorption of HAHD to the Pb(II)-activated wolframite, and in the surface HAHD-Pb(II) complexes, both dithiocarbamate and hydroxamate groups chelated Pb(II) to deliver the four-membered and five-membered ring configurations. The double-site adsorption rendered a closed loop anchor of HAHD on the Pb(II)-activated wolframite surface, which essentially weakened the hydration of OH- ions toward Pb2+, Fe2+ or Mn2+ ions in/on wolframite interface. In addition, the hexyl group exhibits a strong hydrophobization, and the dithiocarbamate displays a selective affinity against alkaline earth metal minerals. These encouraged HAHD to be a strong-power and selective collector for wolframite versus calcite at its low dose. N-[(3-hydroxyamino)-propoxy]-N-hexyl dithiocarbamate promotes wolframite flotation.In situ AFM showed the self-assemble of HAHD on Pb(II)-activated wolframite surface.Both dithiocarbamate and hydroxamate reacted with the Pb(II)-activated wolframite.The double-site adsorption rendered a closed loop anchor to weaken surface hydration.HAHD is a strong-power collector for selective flotation of wolframite against calcite. N-[(3-hydroxyamino)-propoxy]-N-hexyl dithiocarbamate promotes wolframite flotation. In situ AFM showed the self-assemble of HAHD on Pb(II)-activated wolframite surface. Both dithiocarbamate and hydroxamate reacted with the Pb(II)-activated wolframite. The double-site adsorption rendered a closed loop anchor to weaken surface hydration. HAHD is a strong-power collector for selective flotation of wolframite against calcite.
Burden of caring for Alzheimer’s disease or dementia patients in Japan, the US, and EU: results from the National Health and Wellness Survey: a cross-sectional survey
Creators: name: Ohno, Shinya
name: Yirong Chen
name: Sakamaki, Hiroyuki
name: Matsumaru, Naoki
name: Yoshino, Motoaki
name: Tsukamoto, Katsura
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The growing prevalence of Alzheimer’s disease (AD) worldwide has sparked the implementation of national policies to support the growing burden among caregivers of AD/dementia patients. This study aims to quantify and compare the burden of AD/dementia caregivers and evaluate how different living arrangements might impact health outcomes among caregivers in Japan, five European countries (5EU), and the United States (US). This is a cross-sectional study based on existing data from the 2018 National Health and Wellness Survey. Health outcome measures included health-related quality of life (HRQoL), health state utilities, work productivity and activity impairment (WPAI), and measurement of depression and anxiety amongst AD/dementia caregivers and non-caregivers. Pairwise comparisons between AD/dementia caregivers in Japan, 5EU, and the US were conducted. Multivariate analysis was used to compare across groups within each region, with adjustment for potential confounding effects. A higher proportion of caregivers of AD/dementia patients in Japan were 65 years or older as compared to 5EU and US. On the contrary, female caregivers were significantly higher in the US than Japan and 5EU. The HRQoL and health state utilities index scores amongst AD/dementia caregivers were highest in Japan and lowest in the US. Caregivers in Japan incurred the lowest WPAI among the three regions. The proportion of AD/dementia patients reportedly living in an institution was highest in Japan as compared to the US and EU. Notably, US caregivers whose patients lived in an institution experienced significantly less caregiving burden as compared to caregivers whose patients lived in the community. The caregiving burden among AD/dementia caregivers was substantial across the three regions, with similarities and differences between the West and Japan. The lower caregiving burden in Japan was potentially associated with national policies supporting long-term healthcare and institutionalized nursing care facilities for AD/dementia patients.
What to Do with “Prefer Not to Vote” Responses from Contingent Valuation Surveys?
Creators: name: Hwang, Joonghyun
name: Petrolia, Daniel R.
name: Interis, Matthew G.
name: Harri, Ardian
name: Hwang, Joonghyun
name: Petrolia, Daniel R.
name: Interis, Matthew G.
name: Harri, Ardian
Publisher: name: Unknown
Year: 2013
Subjects: subject: Environmental Economics and Policy
subject: Consequentiality
subject: Contingent Valuation
subject: Non-Market Valuation
subject: Non-Votes
subject: Wetlands

description: Arrow et al. (1993), the “Blue Ribbon” panel that issued guidelines for contingent valuation, recommended that respondents to contingent valuation surveys be explicitly allowed to give ‘no-answer’ responses such as ‘don’t know / not sure / prefer not to vote (PNV)’ in addition to the typical ‘yes / no’ responses. However, they do not provide any further guidelines on what to do with such responses. A nationwide contingent valuation (CV) survey in 2011 for the purpose of obtaining welfare estimates of coastal wetland restoration in Louisiana was conducted, and 27 percent of total respondents chose the PNV option. This study identified demographic variables that affect respondents to choose PNV. More interestingly, we found that as the level of offered bid for the proposed environmental project increases, the proportion of ‘yes’ responses decreases, and proportions of ‘no’ and PNV equally increase. We also found that when PNV is compared to ‘yes’, respondents who believe the survey is consequential are less likely to choose PNV than respondents who believe the survey is inconsequential, and respondents who have no clear opinion about the consequentiality of the survey are more likely to choose PNV in both cases in which PNV is compared to ‘yes’ and in which PNV is compared to ‘no’.
Coherent pulse implementations of quantum cryptography protocols resistant to photon number splitting attacks
Creators: name: Acin, Antonio
name: Gisin, Nicolas
name: Scarani, Valerio
Publisher: name: arXiv
Year: 2003
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A new class of quantum cryptography (QC) protocols that are robust against the most general photon number splitting attacks in a weak coherent pulse implementation has been recently proposed. In this article we give a quite exhaustive analysis of several eavesdropping attacks on these schemes. The eavesdropper (Eve) is supposed to have unlimited technological power while the honest parties (Alice and Bob) use present day technology, in particular an attenuated laser as an approximation of a single-photon source. They exploit the nonorthogonality of quantum states for decreasing the information accessible to Eve in the multi-photon pulses accidentally produced by the imperfect source. An implementation of some of these protocols using present day technology allow for a secure key distribution up to distances of $\sim$ 150 km. We also show that strong-pulse implementations, where a strong pulse is included as a reference, allow for key distribution robust against photon number splitting attacks.
description: 16 pages, 11 figures
Network Geometry
Creators: name: Boguna, Marian
name: Bonamassa, Ivan
name: De Domenico, Manlio
name: Havlin, Shlomo
name: Krioukov, Dmitri
name: Serrano, M. Angeles
Publisher: name: arXiv
Year: 2020
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Real networks are finite metric spaces. Yet the geometry induced by shortest path distances in a network is definitely not its only geometry. Other forms of network geometry are the geometry of latent spaces underlying many networks, and the effective geometry induced by dynamical processes in networks. These three approaches to network geometry are all intimately related, and all three of them have been found to be exceptionally efficient in discovering fractality, scale-invariance, self-similarity, and other forms of fundamental symmetries in networks. Network geometry is also of great utility in a variety of practical applications, ranging from the understanding how the brain works, to routing in the Internet. Here, we review the most important theoretical and practical developments dealing with these approaches to network geometry in the last two decades, and offer perspectives on future research directions and challenges in this novel frontier in the study of complexity.
A predator-prey model based on fully parallel cellular automata
Creators: name: He, Mingfeng
name: Ruan, Hongbo
name: Yu, Changliang
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We presented a predator-prey lattice model containing moveable wolves and sheep, which are characterized by Penna double bit strings. Sexual reproduction and child-care strategies are considered. To implement this model in an efficient way, we build a fully parallel Cellular Automata based on a new definition of the neighborhood. We show the roles played by the initial densities of the populations, the mutation rate and the linear size of the lattice in the evolution of this model.
description: 14 pages, including many figures, for Int. J. Mod. Phys. C 14, issue 9
A characterization of complex space forms via Laplace operators
Creators: name: Loi, Andrea
name: Salis, Filippo
name: Zuddas, Fabio
Publisher: name: arXiv
Year: 2019
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: Inspired by the work of Z. Lu and G. Tian \cite{lutian}, in this paper we address the problem of studying those \K\ manifolds satisfying the $Δ$-property, i.e. such that on a neighborhood of each of its points the $k$-th power of the \K Laplacian is a polynomial function of the complex Euclidean Laplacian, for all positive integer $k$ (see below for its definition). We prove two results: 1. if a \K\ manifold satisfies the $Δ$-property then its curvature tensor is parallel; 2. if an Hermitian symmetric space of classical type satisfies the $Δ$-property then it is a complex space form (namely it has constant holomorphic sectional curvature). In view of these results we believe that if a complete and simply-connected \K\ manifold satisfies the $Δ$-property then it is a complex space form.
description: 13 pages
Additional file 3 of Attitudes & behaviors toward the management of tobacco smoking patients: qualitative study with French primary care physicians
Creators: name: Coindard, Guillaume
name: Acquadro, Michaël
name: Chaumont, Raphaël
name: Arnould, Benoit
name: Boisnault, Philippe
name: Collignon-Portes, Rachel
name: Duhot, Didier
name: Raineri, François
name: Tugaut, Béatrice
name: Aubin, Henri-Jean
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Illustrative quotes.
Large angular scale fluctuations of near infrared extragalactic background light based on the IRTS observations
Creators: name: Kim, Min Gyu
name: Lee, Hyung Mok
name: Jeong, Woong-Seob
name: Tsumura, Kohji
name: Seo, Hyungjong
name: Tanaka, Masahiro
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We measure the spatial fluctuations of the Near-Infrared Extragalactic Background Light (NIREBL) from 2$^{\circ}$ to 20$^{\circ}$ in angular scale at the 1.6 and 2.2 $μ$m using data obtained with Near-Infrared Spectrometer (NIRS) on board the Infrared Telescope in Space (IRTS). The brightness of the NIREBL is estimated by subtracting foreground components such as zodiacal light, diffuse Galactic light, and integrated star light from the observed sky. The foreground components are estimated using well-established models and archive data. The NIREBL fluctuations for the 1.6 and 2.2 $μ$m connect well toward the sub-degree scale measurements from previous studies. Overall, the fluctuations show a wide bump with a center at around 1$^{\circ}$ and the power decreases toward larger angular scales with nearly a single power-law spectrum (i.e. \textit{F($\sqrt{l(l+1)C_l/2π}$)} $\sim$ $θ^{-1}$) indicating that the large scale power is dominated by the random spatial distribution of the sources. After examining several known sources, contributors such as normal galaxies, high redshift objects, intra-halo light, and far-IR cosmic background, we conclude that the excess fluctuation at around the 1$^{\circ}$ scale cannot be explained by any of them.
Cooperation among Asymmetric Countries: A Study for the Role of Side Payment in International Environmental Agreements
Creators: name: Dong, Da-Xin
name: Dong, Da-Xin
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: Asymmetry
subject: Coalition Stability
subject: Side Payment/Transfer
subject: Environmental Cooperation

description: By a survey of a range of existing literatures, this article makes a rough summary for previous theoretical findings about the role of side payment in international environmental agreements. If countries are symmetric, we can hardly exploit the transfer to enhance international cooperation. On the contrary, under asymmetric countries assumption, the side payment is often helpful to obtain better global outcome in environmental issues. Even though no general theoretical conclusion can be claimed so far, many meaningful implications will be revealed with the going on of this article.
Additional file 3 of N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions
Creators: name: Haimin Feng
name: Moriyama, Taiki
name: Ohuchida, Kenoki
name: Sheng, Nan
name: Iwamoto, Chika
name: Shindo, Koji
name: Shirahane, Kengo
name: Ikenaga, Naoki
name: Shuntaro Nagai
name: Nakata, Kohei
name: Mizumoto, Kazuhiro
name: Nakamura, Masafumi
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 3: Supplementary Figure S1. Analyses of α-SMA and CK19 immunofluorescence staining in SUIT-2 or PSCs isolated from PDAC patients. PSCs presented a fibroblast-like appearance and expressed α-SMA, but not CK19 (original magnification: × 200). Pancreatic cancer cell (PCCs) line SUIT-2 expressed CK19, but not α-SMA. Supplementary Figure S2. Toxicity effects of NAC to PSCs and PCCs. (A-B) IC50 values were measured in PSC1–3 and PCCs by determined by CellTiter-Glo luminescent cell viability assay after 72 h treatment with indicated NAC concentrations. (C) Representative microscopy time-lapse images of PSC1 and PSC2 cells treated with 6 mM NAC in which concentration toxic to PSCs. (D) (Left) PSC1 and PSC2 cells were treated with 2.5 mM NAC for 48 h, stained with annexin V-FITC/PI, and then analyzed by flow cytometry. (Right) Quantification of apoptotic cells induced by NAC treatment. (E) the expression of cleaved caspase-3, a marker of apoptosis, was determined by western blotting in PSCs. PSCs were treated with PBS (as control), 2.5 mM NAC, or 20μM H2O2 (positive control). (F) the expression of α-SMA, an active marker of PSC, was determined by western blotting in PSC2, which treated with different concertation of NAC with or without supernatant from SUIT-2 (SUIT-SN). (G) Migration of PSC2 after 1 mM NAC treatment with or without SUIT-SN was analyzed. Migrated cell numbers were normalized by total cell numbers. H&E staining; original magnification, × 100. Scale bar = 100 μm. (H-I) Migration and invasion assays of PSCs and PCCs from Fig. 1c-d. Graphs show numbers of cells calculated from five fields. The exact number of migrated cells was counted. Scale bar = 100 μm. H&E staining; original magnification, × 100. (J) Effects of NAC were performed in PCCs and PSCs on mRNA expression of Nrf2, HMOX-1, NQO1, and GCLC. PBS was used as Control. *P
Development Situations and Countermeasures of Low Carbon Ecological Circular Agriculture: A Case Study of Nantong City
Creators: name: Yang, Chun-He
name: Qiao, Qi-Cheng
name: Gu, Wei-Bing
name: Sun, Jia-Feng
name: Yang, Chun-He
name: Qiao, Qi-Cheng
name: Gu, Wei-Bing
name: Sun, Jia-Feng
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: Low carbon
subject: Ecological circular agriculture
subject: Nantong City
subject: Countermeasures

description: Developing the low carbon ecological circular agriculture is an effective approach to realizing low carbon development of agriculture. Through investigation on existing measures and performance of development of low carbon type ecological circular agriculture in Nantong City, we analyzed the potential and problems of Nantong City in developing low carbon type ecological circular agriculture. Finally, with reference to domestic and foreign research achievements and practical experience, we put forward countermeasures for developing low carbon type ecological circular agriculture in Nantong City from building technical system and government guidance.
Bedding-generated particulate matter: implications for rodent studies
Creators: name: Neelakshi Hudda
name: Durant, John L.
name: Nemeth, Alexandra
name: Mann, Phyllis
name: Petitto, Jocelyn
name: Brugge, Douglas
name: Nephew, Benjamin C.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Objectives: Rodents used in scientific research are typically housed in cages containing natural bedding materials. Despite extensive evidence of biological harm from inhaled particulate matter (PM), relatively little work has been performed to measure bedding-generated PM exposure in caged animals used in basic science research. Our objectives were to determine whether bedding-generated PM was present in significant concentrations in rodent cages and to identify the main factors affecting the accumulation and attenuation of bedding-generated PM inside cages. Materials and Methods: We measured PM2.5 concentrations in cages containing common bedding materials (pine, aspen, paper, and corncob) with filter top isolator absent or present on the cages. PM2.5 concentrations were monitored with rats inside cages as well as during artificial manipulation of the bedding (designed to simulate rodent activity). Results and Discussion: Upon rodent digging or mechanical/manual stirring, all four bedding materials produced significant increases in PM2.5 concentrations (as much as 100–200 µg/m3 PM2.5, 50- to 100-fold higher than during periods of no rodent activity), and concentrations in cages fitted with filter tops were an order of magnitude higher than in cages without filter tops. Elevated concentrations were sustained for longer durations in cages with filter tops (5–10 minutes) compared to cages with only bar lids (0–2 minutes). Conclusions: These results indicate that standard laboratory housing conditions can expose rodents to substantial levels of PM2.5. Bedding-generated PM has potential implications as an environmental agent in rodent studies.
Health outcomes and economic burden of hospitalized COVID-19 patients in the United States
Creators: name: Di Fusco, Manuela
name: Shea, Kimberly M
name: Lin, Jay
name: Nguyen, Jennifer L
name: Angulo, Frederick J
name: Benigno, Michael
name: Malhotra, Deepa
name: Emir, Birol
name: Sung, Anita H
name: Hammond, Jennifer L
name: Stoychev, Sophia
name: Charos, Apostolos
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: 60506 Virology
subject: Computational Biology

description: To evaluate health outcomes and the economic burden of hospitalized COVID-19 patients in the United States. Hospitalized patients with a primary or secondary discharge diagnosis code for COVID-19 (ICD-10 code U07.1) from April 1 - October 31, 2020 were identified in the Premier Healthcare COVID-19 Database. Patient demographics, hospitalization characteristics, and concomitant medical conditions were assessed. Hospital length of stay (LOS), in-hospital mortality, hospital charges, and hospital costs were evaluated overall and stratified by age groups, insurance types, and 4 COVID-19 disease progression states based on intensive care unit (ICU) and invasive mechanical ventilation (IMV) usage. Of the 173,942 hospitalized COVID-19 patients, median age was 63 years, 51.0% were male, and 48.5% were covered by Medicare. The most prevalent concomitant medical conditions were cardiovascular disease (73.5%), hypertension (64.8%), diabetes (40.7%), obesity (27.0%), and chronic kidney disease (24.2%). Approximately one-fifth (21.9%) of the hospitalized COVID-19 patients were admitted to the ICU and 16.9% received IMV; most patients (73.6%) did not require ICU admission or IMV, and 12.4% required both. The median hospital LOS was 5 days, in-hospital mortality was 13.6%, median hospital charges were $43,986, and median hospital costs were $12,046. Hospital LOS and in-hospital mortality increased with ICU and/or IMV usage and age; hospital charges and costs increased with ICU and/or IMV usage. Patients with both ICU and IMV usage had the longest median hospital LOS (15 days), highest in-hospital mortality (53.8%), and highest hospital charges ($198,394) and hospital costs ($54,402). This retrospective administrative database analysis relied on coding accuracy and a subset of admissions with validated/reconciled hospital costs. This study summarizes the severe health outcomes and substantial hospital costs of hospitalized COVID-19 patients in the US. The findings support the urgent need for rapid implementation of effective interventions, including safe and efficacious vaccines.
NGTS clusters survey. I. Rotation in the young benchmark open cluster Blanco 1
Creators: name: Gillen, Edward
name: Briegal, Joshua T.
name: Hodgkin, Simon T.
name: Foreman-Mackey, Daniel
name: Van Leeuwen, Floor
name: Jackman, James A. G.
name: McCormac, James
name: West, Richard G.
name: Queloz, Didier
name: Bayliss, Daniel
name: Goad, Michael R.
name: Watson, Christopher A.
name: Wheatley, Peter J.
name: Belardi, Claudia
name: Burleigh, Matthew R.
name: Casewell, Sarah L.
name: Jenkins, James S.
name: Raynard, Liam
name: Smith, Alexis M. S.
name: Tilbrook, Rosanna H.
name: Vines, Jose I.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We determine rotation periods for 127 stars in the ~115 Myr old Blanco 1 open cluster using ~200 days of photometric monitoring with the Next Generation Transit Survey (NGTS). These stars span F5-M3 spectral types (1.2 $\gtrsim M \gtrsim$ 0.3 M$_{\odot}$) and increase the number of known rotation periods in Blanco 1 by a factor of four. We determine rotation periods using three methods: Gaussian process (GP) regression, generalised autocorrelation (G-ACF) and Lomb-Scargle (LS) periodograms, and find that GPs and G-ACF are more applicable to evolving spot modulation patterns. Between mid-F and mid-K spectral types, single stars follow a well-defined rotation sequence from ~2 to 10 days, whereas stars in photometric multiple systems typically rotate faster. This may suggest that the presence of a moderate-to-high mass ratio companion inhibits angular momentum loss mechanisms during the early pre-main sequence, and this signature has not been erased at ~100 Myr. The majority of mid-F to mid-K stars display evolving modulation patterns, whereas most M stars show stable modulation signals. This morphological change coincides with the shift from a well-defined rotation sequence (mid-F to mid-K stars) to a broad rotation period distribution (late-K and M stars). Finally, we compare our rotation results for Blanco 1 to the similarly-aged Pleiades: the single star populations in both clusters possess consistent rotation period distributions, which suggests that the angular momentum evolution of stars follows a well-defined pathway that is, at least for mid-F to mid-K stars, strongly imprinted by ~100 Myr.
description: 19 pages, 14 figures, 2 tables, accepted for publication in MNRAS
Burden of caring for Alzheimer’s disease or dementia patients in Japan, US, and EU: results from the National Health and Wellness Survey: a cross-sectional survey
Creators: name: Ohno, Shinya
name: Yirong Chen
name: Sakamaki, Hiroyuki
name: Matsumaru, Naoki
name: Yoshino, Motoaki
name: Tsukamoto, Katsura
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The growing prevalence of Alzheimer’s disease (AD) worldwide has sparked the implementation of national policies to support the growing burden among caregivers of AD/dementia patients. This study aims to quantify and compare the burden of AD/dementia caregivers and evaluate how different living arrangements might impact health outcomes among caregivers in Japan, five European countries (5EU) and the United States (US). This is a cross-sectional study based on existing data from the 2018 National Health and Wellness Survey. Health outcome measures included health-related quality of life (HRQoL), health state utilities, work productivity and activity impairment (WPAI), and measurement of depression and anxiety amongst AD/dementia caregivers and non-caregivers. Pairwise comparisons between AD/dementia caregivers in Japan, 5EU and the US were conducted. Multivariate analysis was used to compare across groups within each region, with adjustment for potential confounding effects. A higher proportion of caregivers of AD/dementia patients in Japan were 65 years or older as compared to 5EU and US. On the contrary, female caregivers were significantly higher in the US than Japan and 5EU. The HRQoL and health state utilities index scores amongst AD/dementia caregivers were highest in Japan and lowest in the US. Caregivers in Japan incurred the lowest WPAI among the three regions. The proportion of AD/dementia patients reportedly living in an institution was highest in Japan as compared to US and EU. Notably, US caregivers whose patients lived in an institution experienced significantly less caregiving burden as compared to caregivers whose patients lived in the community. The caregiving burden among AD/dementia caregivers were substantial across the three regions, with similarities and differences between the West and Japan. The lower caregiving burden in Japan was potentially associated with national policies supporting long-term healthcare and institutionalized nursing care facilities for AD/dementia patients.
The 2 - particle irreducible effective action in gauge theories
Creators: name: Calzetta, E.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The goal of this paper is to develop the formalism of the two-particle irreducible (2PI) \cite{LW61} (or Cornwall - Jackiw - Tomboulis (CJT) \cite {CJT}) effective action (EA) in a way appropiate to its application to non equilibrium gauge theories. We hope this review article will stimulate new work into this field.
description: 25 pages
Integrated Prevention and Control System for Soil Erosion in Typical Black Soil Region of Northeast China
Creators: name: Sun, Li-Ying
name: Cai, Qiang-Guo
name: Chen, Sheng-Yong
name: He, Ji-Jun
name: Sun, Li-Ying
name: Cai, Qiang-Guo
name: Chen, Sheng-Yong
name: He, Ji-Jun
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: Typical black soil region
subject: Small watershed
subject: Soil and water loss
subject: Comprehensive prevention and control system

description: The black soil region of Northeast China is one of the most important food production bases and commodity grain bases in China. However, the continual loss and degradation of precious black soil resources has led to direct threats to national food security and regional sustainable development. Therefore, it is necessary to summarize integrated prevention and control experience of small watersheds in black soil region of Northeast China. Tongshuang small watershed, a typical watershed in rolling hills of typical black soil areas in Northeast China, is selected as the study area. Based on nearly 50 years’ experience in prevention and control of soil and water loss, the structures and overall benefits of an integrated prevention and control system for soil and water loss are investigated. Then, the ‘three defense lines’ tri-dimensional protection system with reasonable allocation of different types of soil and water control measures from the hill top to gully is systematically analyzed. The first line on the top hill can weaken and block uphill runoff and sediment, hold water resources and improve soil property. The second line on the hill can truncate slope length, slow down the runoff velocity and reduce erosion energy. The third line in the gully is mainly composed of waterfall engineering, which can inhibit soil erosion and restore land resources. The ‘three defense lines’ system is feasible for soil and water loss control of small watersheds in the typical black soil region of Northeast China. Through the application of the in Tongshuang small watershed, There are effective improvements in ecological conditions in Tongshuang small watershed after the application of ‘three defense lines’ soil and water control system. Moreover, the integrated treatment paradigm for soil and water loss in typical black soil region is compared with that in loess region. The results of this study could offer references and experiences for other small watersheds in typical black soil region of Northeast China.
Environmental Protection Legislation on China’s Energy Development and In-situ Conversion
Creators: name: Nan, Jing-Yu
name: Nan, Jing-Yu
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: Energy development and in-situ conversion
subject: Environmental protection
subject: Local legislation
subject: Basic environmental legal system
subject: Energy legislation

description: China's poor energy development and in-situ conversion legislation, environment laws and energy laws lead to a severe environmental issue in energy source. This paper uses comparison and logical methods to discuss Chapter 4 of Energy Law (Draft for Soliciting Opinions). Energy development is taken as a separate chapter; in-situ energy conversion is added to energy processing and conversion, common features are summarized to form general provisions and other provisions. According to respective characteristics of system for total amount control of energy development, performance guarantee system, environmental trust fund system, energy retaining system and environmental lien system, incorporate them into energy development, in-situ energy conversion and energy processing and conversion, in the hope of solving China’s shortage of supply for environmental protection laws on energy development and in-situ conversion, responding to times of environmental protection, and optimizing China’s Energy Law.
Additional file 1 of Serum rheumatoid factor IgA, anti-citrullinated peptide antibodies with secretory components, and anti-carbamylated protein antibodies associate with interstitial lung disease in rheumatoid arthritis
Creators: name: Oka, Shomi
name: Higuchi, Takashi
name: Furukawa, Hiroshi
name: Shimada, Kota
name: Okamoto, Akira
name: Hashimoto, Atsushi
name: Komiya, Akiko
name: Saisho, Koichiro
name: Yoshikawa, Norie
name: Katayama, Masao
name: Matsui, Toshihiro
name: Fukui, Naoshi
name: Migita, Kiyoshi
name: Tohma, Shigeto
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Additional file 1.
Supplementary Material from Managing flooding: from a problem to an opportunity
Creators: name: Ashley, Richard
name: Gersonius, Berry
name: Horton, Bruce
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The paper argues that the concept and practice of sustainability have proved too difficult to achieve within traditional water management, and there is a lack of political will to move towards truly sustainable water services. Instead, compromised concepts, including resistance, resilience, ecosystem services, natural capital and adaptation are defining approaches; each of which may contribute partially to sustainability. Pressures due to the changing climate, ecological degradation, human demands, urbanization and deteriorating assets are challenging sustainability and compelling changes to water management. Water is now seen less as a problem to be managed than as an opportunity, as wherever situated, water brings many opportunities to contribute to anthropogenic needs. New ideas are helping to frame the way in which water management is being approached: (i) waste is no longer waste, but a potential resource within a circular economy; (ii) the interconnectedness of infrastructure systems and services and circularity of the water cycle mean there is a need to integrate approaches; (iii) nature-based systems should be preferenced for water infrastructure. These issues and ideas are considered here, together with examples of schemes showing that managing flooding can lead to wider benefits, and potential longer-term sustainability.This article is part of the theme ‘Urban flood resilience’.
Additional file 1 of How context affects people’s willingness to register for the deceased organ donation programme
Creators: name: AlHajri, Lamia
name: Amna AlHebsi
name: AlSuwaidi, Maryam
Publisher: name: figshare
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Topic guide used during the in semi-structured interviews.
Additional file 1 of Multi-PLI: interpretable multi‐task deep learning model for unifying protein–ligand interaction datasets
Creators: name: Hu, Fan
name: Jiaxin Jiang
name: Dongqi Wang
name: Muchun Zhu
name: Yin, Peng
Publisher: name: figshare
Year: 2021
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1.
Budget impact analysis of Jivi® (damoctocog alfa pegol, BAY 94-9027) in severe Hemophilia A in Japan
Creators: name: Teruhisa Fujii
name: Kidoguchi, Yuko
name: Takahashi, Noriko
name: Yu, Eric
name: Dilinuer Ainiwaer
name: Byrne, Aidan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Hemophilia A (HA) is a genetic bleeding disorder characterized by a deficiency of clotting factor VIII (FVIII) requiring lifelong prophylactic treatment typically with conventional standard half-life recombinant FVIII (rFVIII). Lifelong prophylaxis impacts budget, patient adherence, and long-term outcomes. The consequent economic and treatment burden may be reduced by using novel extended half-life recombinant FVIII. The objective of this analysis was to estimate the budget impact of introducing Jivi® (damoctocog alfa pegol, BAY 94-9027), hereafter referred to as BAY 94-9027, as an on-demand and prophylactic treatment for severe HA from a Japanese payer’s perspective. A global budget impact model was adapted to the Japanese setting using data obtained via a targeted literature review of Japanese sources. The model considered a five-year time horizon for a market without and with BAY 94-9027. Using annual per-patient costs, the total cost of on-demand and prophylactic treatment of adolescent and adult patients with severe HA (without inhibitors) were analyzed. The model used summary of product characteristics (SmPC) and clinical trial dosing, and unit costs from the National Health Insurance (NHI) drug price database. Comparators considered in the model comprised of currently available products in Japan. Projected BAY 94-9027 uptake ranged from 4% to 9% over the five years (2020-2024). Introduction of BAY 94-9027 for the treatment of severe HA is estimated to decrease the overall budget by 1.5%, with a cost saving of approximately $67 million USD (¥7.4 billion JPY) over five years. Estimated cost savings associated with BAY 94-9027 ranged from $1.4 million USD (¥156 million JPY) in 2020 to $23 million USD (¥2.6 billion JPY) in 2024 for the Japanese healthcare system. There were limitations associated with the study. The Japanese guidelines consulted during the targeted literature review of national data sources in Japan were based on global data as reference sources. Also, studies reporting the bleeding rate, dosing guidelines and economic burden in the Japanese population identified by the targeted literature review were limited hence global studies were used and may not have been representative of the Japanese population. BAY 94-9027 can reduce total severe HA treatment costs, driven by lower annual rFVIII utilization, and a narrow weekly dosing range compared to competitor products in the Japanese market.
Anomalously localized states and multifractal correlations of critical wavefunctions in two-dimensional electron systems with spin-orbital interactions
Creators: name: Obuse, H.
name: Yakubo, K.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Anomalously localized states (ALS) at the critical point of the Anderson transition are studied for the SU(2) model belonging to the two-dimensional symplectic class. Giving a quantitative definition of ALS to clarify statistical properties of them, the system-size dependence of a probability to find ALS at criticality is presented. It is found that the probability increases with the system size and ALS exist with a finite probability even in an infinite critical system, though the typical critical states are kept to be multifractal. This fact implies that ALS should be eliminated from an ensemble of critical states when studying critical properties from distributions of critical quantities. As a demonstration of the effect of ALS to critical properties, we show that the distribution function of the correlation dimension of critical wavefunctions becomes a delta function in the thermodynamic limit only if ALS are eliminated.
description: 7 pages, 6 figures
A faithful analytical effective one body waveform model for spin-aligned, moderately eccentric, coalescing black hole binaries
Creators: name: Chiaramello, Danilo
name: Nagar, Alessandro
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a new effective-one-body (EOB) model for eccentric binary coalescences. The model stems from the state-of-the-art model TEOBResumS$\_$SM for circularized coalescing black-hole binaries, that is modified to explicitly incorporate eccentricity effects both in the radiation reaction and in the waveform. Using Regge-Wheeler-Zerilli type calculations of the gravitational wave losses as benchmarks, we find that a rather accurate ($\sim 1\%$) expression for the radiation reaction along mildly eccentric orbits ($e \sim 0.3$) is given by dressing the current, EOB-resummed, circularized angular momentum flux, with a leading-order (Newtonian-like) prefactor valid along general orbits. An analogous approach is implemented for the waveform multipoles. The model is then completed by the usual merger-ringdown part informed by circularized numerical relativity (NR) simulations. The model is validated against the 22, publicly available, NR simulations calculated by the Simulating eXtreme Spacetime (SXS) collaboration, with mild eccentricities, mass ratios between 1 and 3 and up to rather large dimensionless spin values ($\pm 0.7$). The maximum maximum EOB/NR unfaithfulness, calculated with Advanced LIGO noise, is at most of order $3\%$. The analytical framework presented here should be seen as a promising starting point for developing highly-faithful waveform templates driven by eccentric dynamics for present, and possibly future, gravitational wave detectors.
description: 6 pages, 5 figures. This version (v5) matches published version
Stenaelurillus mirabilis Wesolowska & Russell-Smith 2000
Creators: name: Wesołowska, Wanda
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Stenaelurillus
Stenaelurillus mirabilis

description: Stenaelurillus mirabilis Wesołowska & Russell-Smith, 2000
 Stenaelurillus mirabilis Wesołowska & Russell-Smith, 2000: 102, figs 281-289.
MATERIAL EXAMINED. — Kenya,Tsavo National Park East, Aruba Lodge, 3°21’S, 38°49’E in litter, 15.VIII.1965, leg. V. Mahnert, 1 ♂ (MHN).
DISTRIBUTION. — Hitherto known only from Mkomazi Game Reserve in NE Tanzania. For the first time recorded in the neighbouring Tsavo N.P. in Kenya.
description: Published as part of Wesołowska, Wanda, 2014, Further notes on the genus Stenaelurillus Simon, 1885 (Araneae, Salticidae) in Africa with descriptions of eight new species, pp. 595-622 in Zoosystema 36 (3) on page 608, DOI: 10.5252/z2014n3a3, http://zenodo.org/record/5159326
Para una soberanía digital en equidad: un derecho a reivindicar
Creators: name: Arroyo Prieto, Lídia
Publisher: name: Zenodo
Year: 2024
Subjects: Digital skills
Equity
Gender inequalities
Intersectionality
Digital rights
Digital sovereignty

description: Recurso educativo sobre soberanía digital en equidad y empoderamiento digital con perspectiva de género interseccional, dirigido a profesorado de educación secundaria.

La publicación se ha elaborado en el marco del proyecto Reto. El proyecto de investigación ha sido impulsado por EduAlter con el apoyo financiero de la Agencia Catalana de Cooperación al Desarrollo (ACCD) y ha estado coordinado por Milagros Sáinz, directora del grupo Género y TIC del IN3 en la Universitat Oberta de Catalunya, como investigadora principal.