cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Proteomic Analysis of the Differential Protein Expression Reveals Nuclear GAPDH in Activated T Lymphocytes
Creators: name: Wang, Tzu-Chien V.
name: Sheng, Wei-Yun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Despite the important role of T cell activation in the adaptive immunity, very little is known about the functions of proteins that are differentially expressed in the activated T cells. In this study, we have employed proteomic approach to study the differentially expressed proteins in activated T cells. A total of 25 proteins was characterized that displayed a decreased expression, while a total of 20 proteins was characterized that displayed an increased expression in the activated T cells. Among them, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified unexpectedly as one of the up-regulated proteins. Western blot analysis of proteins separated by 2-dimensional gel electrophoresis had identified several modified GAPDHs which were detectable only in the activated T cells, but not in resting T cells. These modified GAPDHs had higher molecular mass and more basic PI, and were present in the nucleus of activated T cells. Promoter occupancy studies by chromatin immunoprecipitation assay revealed that nuclear GAPDH could be detected in the promoter of genes that were up-regulated during T cell activation, but not in the promoter of genes that were not unaffected or down-regulated. Our results suggest that nuclear GAPDH may function as transcriptional regulator in activated T cells.
Rab11 Helps Maintain Apical Crumbs and Adherens Junctions in the Drosophila Embryonic Ectoderm
Creators: name: Peifer, Mark
name: Sawyer, Jessica K.
name: Roeth, Jeremiah F.
name: Wilner, Daniel A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundTissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this plasticity in cell adhesion involves regulated trafficking of junctional proteins.Methodology/Principal FindingsHere we explored trafficking of junctional proteins in two well-characterized model epithelia, the Drosophila embryonic ectoderm and amnioserosa. We find that DE-cadherin, the transmembrane protein of adherens junctions, is actively trafficked through putative vesicles, and appears to travel through both Rab5-positive and Rab11-positive structures. We manipulated the functions of Rab11 and Rab5 to examine the effects on junctional stability and morphogenesis. Reducing Rab11 function, either using a dominant negative construct or loss of function alleles, disrupts integrity of the ectoderm and leads to loss of adherens junctions. Strikingly, the apical junctional regulator Crumbs is lost before AJs are destabilized, while the basolateral protein Dlg remains cortical. Altering Rab5 function had less dramatic effects, not disrupting adherens junction integrity but affecting dorsal closure.Conclusions/SignificanceWe contrast our results with what others saw when disrupting other trafficking regulators, and when disrupting Rab function in other tissues; together these data suggest distinct mechanisms regulate junctional stability and plasticity in different tissues.
Bayesian Optimization For Multi-Objective Mixed-Variable Problems
Creators: name: Sheikh, Haris Moazam
name: Marcus, Philip S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Optimizing multiple, non-preferential objectives for mixed-variable, expensive black-box problems is important in many areas of engineering and science. The expensive, noisy, black-box nature of these problems makes them ideal candidates for Bayesian optimization (BO). Mixed-variable and multi-objective problems, however, are a challenge due to BO's underlying smooth Gaussian process surrogate model. Current multi-objective BO algorithms cannot deal with mixed-variable problems. We present MixMOBO, the first mixed-variable, multi-objective Bayesian optimization framework for such problems. Using MixMOBO, optimal Pareto-fronts for multi-objective, mixed-variable design spaces can be found efficiently while ensuring diverse solutions. The method is sufficiently flexible to incorporate different kernels and acquisition functions, including those that were developed for mixed-variable or multi-objective problems by other authors. We also present HedgeMO, a modified Hedge strategy that uses a portfolio of acquisition functions for multi-objective problems. We present a new acquisition function, SMC. Our results show that MixMOBO performs well against other mixed-variable algorithms on synthetic problems. We apply MixMOBO to the real-world design of an architected material and show that our optimal design, which was experimentally fabricated and validated, has a normalized strain energy density $10^4$ times greater than existing structures.
Recombinant Mouse PAP Has pH-Dependent Ectonucleotidase Activity and Acts through A1-Adenosine Receptors to Mediate Antinociception
Creators: name: Sowa, Nathaniel A.
name: Vadakkan, Kunjumon I.
name: Zylka, Mark J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Prostatic acid phosphatase (PAP) is expressed in nociceptive neurons and functions as an ectonucleotidase. When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A1-adenosine receptor (A1R) activation. In this study, we purified the secretory isoform of mouse (m)PAP using the baculovirus expression system to determine if recombinant mPAP also had antinociceptive properties. We found that mPAP dephosphorylated AMP, and to a much lesser extent, ADP at neutral pH (pH 7.0). In contrast, mPAP dephosphorylated all purine nucleotides (AMP, ADP, ATP) at an acidic pH (pH 5.6). The transmembrane isoform of mPAP had similar pH-dependent ectonucleotidase activity. A single intraspinal injection of mPAP protein had long-lasting (three day) antinociceptive properties, including antihyperalgesic and antiallodynic effects in the Complete Freund's Adjuvant (CFA) inflammatory pain model. These antinociceptive effects were transiently blocked by the A1R antagonist 8-cyclopentyl-1, 3-dipropylxanthine (CPX), suggesting mPAP dephosphorylates nucleotides to adenosine to mediate antinociception just like human and bovine PAP. Our studies indicate that PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity. The ability to metabolize nucleotides in a pH-dependent manner could be relevant to conditions like inflammation where tissue acidosis and nucleotide release occur. Lastly, our studies demonstrate that recombinant PAP protein can be used to treat chronic pain in animal models.
title: The structure of measurements and states in quantum theory
title: Struktur der Messungen und Zustände in der Quantenmechanik
titleType: AlternativeTitle
Creators: name: Kleinmann, Matthias
Publisher: name: Universitätsbibliothek Siegen
Year: 2019
Subjects: subject: 530 Physik
subject: foundations of quantum theory
subject: generalized probabilistic theories
subject: Quantenzustand
subject: Messprozess
subject: Quantenmechanik
subject: Wahrscheinlichkeitstheorie

description: Diese Arbeit behandelt die Struktur der Quantenmechanik mit Fokus darauf, was die Struktur von Zuständen und Messungen im Formalismus der Quantenmechanik auszeichnet. Ein sehr allgemeiner Formalismus um beide Begrifflichkeiten zu beschreiben ist durch den operationellen Formalismus der verallgemeinerten probabilistischen Theorien gegeben. Die Verallgemeinerung wird durch eine Abstraktion des reellen Vektorraums der hermiteschen Operatoren erreicht, sowie durch eine Abstraktion von positiv-Semidefinitheit. Beide Konzepte sind hinreichend um das Grundgerüst der Quantenmechanik zu erhalten, jedoch erweitern verallgemeinere probabilistische Theorien diese in einer solchen Weise, dass sie auf nahezu jede operationellen Theorie der Physik anwendbar sind. In dieser Arbeit wird die Rolle der Quantenmechanik innerhalb dieses Formalismus diskutiert, insbesondere bezüglich der Frage, welche Konzepte der Quantenmechanik eigen sind und welche Konzepte lediglich in der Tatsache gegründet sind, dass die Quantenmechanik ein Spezialfall der verallgemeinerten probabilistischen Theorien ist.
description: This thesis concerns the structure of quantum theory with a focus on what states and measurements are according to the formalism of quantum theory itself. A very general mathematical framework for a theory to capture both notions is the operational framework of general probabilistic theories. Hereby, the generalization is achieved by considering an abstraction of the real vector space of Hermitian operators and an abstraction of the concept of positive semidefiniteness. These two concepts are enough to recover the skeleton of quantum theory, but general probabilistic theories broaden these notions to be applicable to virtually any conceivable operational theory of physics. This thesis addresses the role of quantum theory within this framework, specifically addressing the question which concepts are native to quantum theory and which concepts are due to the fact that quantum theory is an instance of a general probabilistic theory.
Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector
Creators: name: Willard, Francis S.
name: Kimple, Randall J.
name: Li, Xiaoyan
name: Oestreich, Emily A.
name: Willard, Melinda D.
name: Zylka, Mark J.
name: Snider, William D.
name: Doyle, Declan A.
name: Siderovski, David P.
name: Sowa, Nathaniel A.
name: Kimple, Adam J.
name: Soundararajan, Meera
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundRegulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Gα-mediated GTP hydrolysis (“GTPase-accelerating proteins” or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Gα GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specific effector. However, more recent data from mammals and Drosophila imply that, in vivo, RGS14 may instead be an effector of Ras.Methodology/Principal FindingsFull-length and truncated forms of purified RGS14 protein were found to bind indiscriminately in vitro to both Rap- and Ras-family GTPases, consistent with prior literature reports. In stark contrast, however, we found that in a cellular context RGS14 selectively binds to activated H-Ras and not to Rap isoforms. Co-transfection / co-immunoprecipitation experiments demonstrated the ability of full-length RGS14 to assemble a multiprotein complex with components of the ERK MAPK pathway in a manner dependent on activated H-Ras. Small interfering RNA-mediated knockdown of RGS14 inhibited both nerve growth factor- and basic fibrobast growth factor-mediated neuronal differentiation of PC12 cells, a process which is known to be dependent on Ras-ERK signaling.Conclusions/SignificanceIn cells, RGS14 facilitates the formation of a selective Ras·GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate H-Ras-dependent neuritogenesis. This cellular function for RGS14 is similar but distinct from that recently described for its closely-related paralogue, RGS12, which shares the tandem Ras-binding domain architecture with RGS14.
Limitations for nonlinear observation over erasure channel
Creators: name: Diwadkar, Amit
name: Vaidya, Umesh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we study the problem of state observation of nonlinear systems over an erasure channel. The notion of mean square exponential stability is used to analyze the stability property of observer error dynamics. The main results of this paper prove, fundamental limitation arises for mean square exponential stabilization of the observer error dynamics, expressed in terms of probability of erasure, and positive Lyapunov exponents of the system. Positive Lyapunov exponents are a measure of average expansion of nearby trajectories on an attractor set for nonlinear systems. Hence, the dependence of limitation results on the Lyapunov exponents highlights the important role played by non-equilibrium dynamics in observation over an erasure channel. The limitation on observation is also related to measure-theoretic entropy of the system, which is another measure of dynamical complexity. The limitation result for the observation of linear systems is obtained as a special case, where Lyapunov exponents are shown to emerge as the natural generalization of eigenvalues from linear systems to nonlinear systems.
Canadian Gallup Poll # 389
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Federal election vote intent(1); past federal elections vote(1); traffic infractions(3); political parties(1); TV influence on family life(2); federal government job performance(1); eating out(2); current party preference(1); inflation(1). Note: Demographics(14).
Fokker-Planck Description of Wealth Dynamics and the Origin of Pareto's Law
Creators: name: Boghosian, Bruce M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Finance (q-fin.GN)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Economics and business
subject: FOS: Physical sciences

description: The so-called "Yard-Sale Model" of wealth distribution posits that wealth is transferred between economic agents as a result of transactions whose size is proportional to the wealth of the less wealthy agent. In recent work [B.M. Boghosian, "Kinetics of Wealth and the Pareto Law," {\it Phys. Rev. E} {\bf 89} (2014) 042804], it was shown that this results in a Fokker-Planck equation governing the distribution of wealth. With the addition of a mechanism for wealth redistribution, it was further shown that this model results in stationary wealth distributions that are very similar in form to Pareto's well known law. In this paper, a much simpler derivation of that Fokker-Planck equation is presented.
description: 6 pages
Improving Parametric Neural Networks for High-Energy Physics (and Beyond)
Creators: name: Anzalone, Luca
name: Diotalevi, Tommaso
name: Bonacorsi, Daniele
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Signal-background classification is a central problem in High-Energy Physics (HEP), that plays a major role for the discovery of new fundamental particles. A recent method -- the Parametric Neural Network (pNN) -- leverages multiple signal mass hypotheses as an additional input feature to effectively replace a whole set of individual classifiers, each providing (in principle) the best response for the corresponding mass hypothesis. In this work we aim at deepening the understanding of pNNs in light of real-world usage. We discovered several peculiarities of parametric networks, providing intuition, metrics, and guidelines to them. We further propose an alternative parametrization scheme, resulting in a new parametrized neural network architecture: the AffinePNN; along with many other generally applicable improvements, like the balanced training procedure. Finally, we extensively and empirically evaluate our models on the HEPMASS dataset, along its imbalanced version (called HEPMASS-IMB) we provide here for the first time, to further validate our approach. Provided results are in terms of the impact of the proposed design decisions, classification performance, and interpolation capability, as well.
description: Published at MLST. Code available at: https://github.com/Luca96/affine-parametric-networks
Skeletal Muscle Differentiation Evokes Endogenous XIAP to Restrict the Apoptotic Pathway
Creators: name: Smith, Michelle I.
name: Huang, Yolanda Y.
name: Deshmukh, Mohanish
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Myotube apoptosis occurs normally during muscle development and aging but it can lead to destruction of skeletal muscle in neuromuscular diseases. Therefore, understanding how myotube apoptosis is regulated is important for developing novel strategies for treatment of muscle loss. We investigated the regulation of apoptosis in skeletal muscle and report a striking increase in resistance to apoptosis following differentiation. We find mitotic C2C12 cells (myoblast-like cells) are sensitive to cytosolic cytochrome c microinjection. However, differentiated C2C12 cells (myotube-like cells) and primary myotubes are markedly resistant. This resistance is due to endogenous X-linked inhibitor of apoptotic protein (XIAP). Importantly, the selective difference in the ability of XIAP to block myotube but not myoblast apoptosis is not due to a change in XIAP but rather a decrease in Apaf-1 expression. This decrease in Apaf-1 links XIAP to caspase activation and death. Our findings suggest that in order for myotubes to die, they may degrade XIAP, functionally inactivate XIAP or upregulate Apaf-1. Importantly, we identify a role for endogenous Smac in overcoming XIAP to allow myotube death. However, in postmitotic cardiomyocytes, where XIAP also restricts apoptosis, endogenous Smac was not capable of overcoming XIAP to cause death. These results show that as skeletal muscle differentiate, they become resistant to apoptosis because of the ability of XIAP to regulate caspase activation. The increased restriction of apoptosis in myotubes is presumably important to ensure the long term survival of these postmitotic cells as they play a vital role in the physiology of organisms.
Particle energisation in a collapsing magnetic trap model: the relativistic regime
Creators: name: Oskoui, Solmaz Eradat
name: Neukirch, Thomas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In solar flares, a large number of charged particles is accelerated to high energies. By which physical processes this is achieved is one of the main open problems in solar physics. It has been suggested that during a flare, regions of the rapidly relaxing magnetic field can form a collapsing magnetic trap (CMT) and that this trap may contribute to particle energisation.} In this Research Note we focus on a particular analytical CMT model based on kinematic magnetohydrodynamics. Previous investigations of particle acceleration for this CMT model focused on the non-relativistic energy regime. It is the specific aim of this Research Note to extend the previous work to relativistic particle energies. Particle orbits were calculated numerically using the relativistic guiding centre equations. We also calculated particle orbits using the non-relativistic guiding centre equations for comparison. For mildly relativistic energies the relativistic and non-relativistic particle orbits mainly agree well, but clear deviations are seen for higher energies. In particular, the final particle energies obtained from the relativistic calculations are systematically lower than the energies reached from the corresponding non-relativistic calculations, and the mirror points of the relativistic orbits are systematically higher than for the corresponding non-relativistic orbits. While the overall behaviour of particle orbits in CMTs does not differ qualitatively when using the relativistic guiding centre equations, there are a few systematic quantitative differences between relativistic and non-relativistic particle dynamics.
description: 4 pages, 2 figures, accepted by Astronomy and Astrophysics
Robustness of Quantum Spin Hall Effect in an External Magnetic Field
Creators: name: Zhang, Song-Bo
name: Zhang, Yan-Yang
name: Shen, Shun-Qing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The edge states in the quantum spin Hall effect are expected to be protected by time reversal symmetry. The experimental observation of the quantized conductance was reported in the InAs/GaSb quantum well {[}Du et al, arXiv:1306.1925{]}, up to a large magnetic field, which raises a question on the robustness of the edge states in the quantum spin Hall effect under time reversal symmetry breaking. Here we present a theoretical calculation on topological invariants for the Benevig-Hughes-Zhang model in an external magnetic field, and find that the quantum spin Hall effect retains robust up to a large magnetic field. The critical value of the magnetic field breaking the quantum spin Hall effect is dominantly determined by the band gap at the $Γ$ point instead of the indirect band gap between the conduction and valence bands. This illustrates that the quantum spin Hall effect could persist even under time reversal symmetry breaking.
description: 9 pages, 5 figures, to appear in Phys. Rev. B
Reliable identification of protein-protein interactions by crosslinking mass spectrometry
Creators: name: Lenz, Swantje
name: Sinn, Ludwig
name: O'Reilly, Francis
name: Fischer, Lutz
name: Wegner, Fritz
name: Rappsilber, Juri
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 570 Biowissenschaften; Biologie
subject: protein-protein interactions
subject: crosslinking mass spectrometry
subject: statistical methods
subject: proteome informatics
subject: structural biology

description: Protein-protein interactions govern most cellular pathways and processes, and multiple technologies have emerged to systematically map them. Assessing the error of interaction networks has been a challenge. Crosslinking mass spectrometry is currently widening its scope from structural analyses of purified multi-protein complexes towards systems-wide analyses of protein-protein interactions (PPIs). Using a carefully controlled large-scale analysis of Escherichia coli cell lysate, we demonstrate that false-discovery rates (FDR) for PPIs identified by crosslinking mass spectrometry can be reliably estimated. We present an interaction network comprising 590 PPIs at 1% decoy-based PPI-FDR. The structural information included in this network localises the binding site of the hitherto uncharacterised protein YacL to near the DNA exit tunnel on the RNA polymerase.
R code used in meta-analysis of debris-covered glacier melt
Creators: name: Winter-Billington, A
Publisher: name: Zenodo
Year: 2019
Subjects: glacier
debris-cover
model
melt
empirical
temperature-index
validation

description: This is the R code used to generate the results in the paper Accuracy of Empirical Models of Debris-Covered Glacier Melt, by Winter-Billington A, Moore RD and Dadic R, which is currently in preparation for publication. The code processes the datasets coredata.csv and dokriani.csv which are also available on this account. It fits mixed-effects models and saves the estimated coefficients, then runs leave-one-out cross-validation on the fitted models and saves the performance metrics. It also computes the 95 % prediction limits for predictions.
Canadian Gallup Poll # 302
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Upcoming federal election: interest, vote intent(5); past federal elections vote(1); Canada's flag and anthem(2); relations between French and English speaking Canadians(1); Canada's dependence on US, defense policies(3); strikes in public utilities(2); banning sale of alcoholic beverages in the province(1). Note: Demographics(14). Dropped: driver's license; country of origin. Added: voting eligibility, number of people over 21 in the household.
Double Fu-teleportation and anomalous Coulomb blockade in a Majorana-hosted superconducting island
Creators: name: Hao, Yiru
name: Zhang, Gu
name: Liu, Donghao
name: Liu, Dong E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the temperature dependence of Coulomb Blockade peak conductance based on a Majorana-hosted superconducting island. In the low-temperature regime, we discover a coherent double Fu-teleportation (FT) process, where any independent tunneling process always involves two coherent FTs; and we also find an anomalous universal scaling behavior, which shows a transition from a [max(T,eV)]^6 to a [max(T,eV)]^3 conductance behavior as increasing energy scale. In the high-temperature regime, using the familiar rate equation method, we find that the conductance is proportional to the reciprocal of the temperature and shows a non-monotonic temperature-dependence. Both the anomalous power-law behavior and non-monotonic temperature-dependence can be distinguished from the conductance peak in the traditional Coulomb block, and therefore, serve as a hallmark for the non-local transport in the topological superconducting island.
description: 11 pages 3 figures, minor changes of the main text and references
Somatic LKB1 Mutations Promote Cervical Cancer Progression
Creators: name: Bardeesy, Nabeel
name: Akbay, Esra A.
name: Kwiatkowski, David J.
name: Shimamura, Takeshi
name: Wingo, Shana N.
name: Boren, Todd
name: Schorge, John O.
name: Miller, David S.
name: Sharpless, Norman E.
name: Liang, Mei-Chi
name: Wong, Kwok-Kin
name: Contreras, Cristina M.
name: Castrillon, Diego H.
name: Gallardo, Teresa D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Human Papilloma Virus (HPV) is the etiologic agent for cervical cancer. Yet, infection with HPV is not sufficient to cause cervical cancer, because most infected women develop transient epithelial dysplasias that spontaneously regress. Progression to invasive cancer has been attributed to diverse host factors such as immune or hormonal status, as no recurrent genetic alterations have been identified in cervical cancers. Thus, the pressing question as to the biological basis of cervical cancer progression has remained unresolved, hampering the development of novel therapies and prognostic tests. Here we show that at least 20% of cervical cancers harbor somatically-acquired mutations in the LKB1 tumor suppressor. Approximately one-half of tumors with mutations harbored single nucleotide substitutions or microdeletions identifiable by exon sequencing, while the other half harbored larger monoallelic or biallelic deletions detectable by multiplex ligation probe amplification (MLPA). Biallelic mutations were identified in most cervical cancer cell lines; HeLa, the first human cell line, harbors a homozygous 25 kb deletion that occurred in vivo. LKB1 inactivation in primary tumors was associated with accelerated disease progression. Median survival was only 13 months for patients with LKB1-deficient tumors, but >100 months for patients with LKB1-wild type tumors (P = 0.015, log rank test; hazard ratio = 0.25, 95% CI = 0.083 to 0.77). LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers. Furthermore, LKB1 status can be exploited clinically to predict disease recurrence.
Automated Detection of Doxing on Twitter
Creators: name: Karimi, Younes
name: Squicciarini, Anna
name: Wilson, Shomir
Publisher: name: arXiv
Year: 2022
Subjects: subject: Social and Information Networks (cs.SI)
subject: Artificial Intelligence (cs.AI)
subject: Computation and Language (cs.CL)
subject: Cryptography and Security (cs.CR)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: H.4.3; I.7.0; J.4; K.4.2
subject: 68T01, 68T50, 91F20

description: Doxing refers to the practice of disclosing sensitive personal information about a person without their consent. This form of cyberbullying is an unpleasant and sometimes dangerous phenomenon for online social networks. Although prior work exists on automated identification of other types of cyberbullying, a need exists for methods capable of detecting doxing on Twitter specifically. We propose and evaluate a set of approaches for automatically detecting second- and third-party disclosures on Twitter of sensitive private information, a subset of which constitutes doxing. We summarize our findings of common intentions behind doxing episodes and compare nine different approaches for automated detection based on string-matching and one-hot encoded heuristics, as well as word and contextualized string embedding representations of tweets. We identify an approach providing 96.86% accuracy and 97.37% recall using contextualized string embeddings and conclude by discussing the practicality of our proposed methods.
description: 24 pages, 1 figure. Accepted in the 25th ACM Conference on Computer-Supported Cooperative Work and Social Computing (ACM CSCW 2022)
Canadian Gallup Poll # 323
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); economic conditions(1); national lottery(1); labor unions and employment(1); birth control pills(1); image of political leaders(3); Canada and socialism(1); US capital investment in Canada(2). Note: Demographics(11).
Stable Patterns of Gene Expression Regulating Carbohydrate Metabolism Determined by Geographic Ancestry
Creators: name: Mapara, Sabeen
name: Alder, Brian D.
name: Wu, Samuel S.
name: Parker, Joel S.
name: Stouffer, George A.
name: Lineberger, Robert E.
name: Schisler, Jonathan C.
name: Charles, Peter C.
name: Meredith, Dane
name: Patterson, Cam
name: Hilliard, Eleanor G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundIndividuals of African descent in the United States suffer disproportionately from diseases with a metabolic etiology (obesity, metabolic syndrome, and diabetes), and from the pathological consequences of these disorders (hypertension and cardiovascular disease).Methodology/Principal FindingsUsing a combination of genetic/genomic and bioinformatics approaches, we identified a large number of genes that were both differentially expressed between American subjects self-identified to be of either African or European ancestry and that also contained single nucleotide polymorphisms that distinguish distantly related ancestral populations. Several of these genes control the metabolism of simple carbohydrates and are direct targets for the SREBP1, a metabolic transcription factor also differentially expressed between our study populations.Conclusions/SignificanceThese data support the concept of stable patterns of gene transcription unique to a geographic ancestral lineage. Differences in expression of several carbohydrate metabolism genes suggest both genetic and transcriptional mechanisms contribute to these patterns and may play a role in exacerbating the disproportionate levels of obesity, diabetes, and cardiovascular disease observed in Americans with African ancestry.
Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells
Creators: name: Ting, Jenny P.
name: McElvania-TeKippe, Erin
name: Allen, Irving C.
name: Wardenburg, Juliane Bubeck
name: Craven, Robin R.
name: Duncan, Joseph A.
name: Gao, Xi
name: Gris, Denis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Community Acquired Methicillin Resistant Staphylococcus aureus (CA-MRSA) causes severe necrotizing infections of the skin, soft tissues, and lungs. Staphylococcal α-hemolysin is an essential virulence factor in mouse models of CA-MRSA necrotizing pneumonia. S. aureus α-hemolysin has long been known to induce inflammatory signaling and cell death in host organisms, however the mechanism underlying these signaling events were not well understood. Using highly purified recombinant α-hemolysin, we now demonstrate that α-hemolysin activates the Nucleotide-binding domain and leucine-rich repeat containing gene family, pyrin domain containing 3 protein (NLRP3)-inflammasome, a host inflammatory signaling complex involved in responses to pathogens and endogenous danger signals. Non-cytolytic mutant α-hemolysin molecules fail to elicit NLRP3-inflammasome signaling, demonstrating that the responses are not due to non-specific activation of this innate immune signaling system by bacterially derived proteins. In monocyte-derived cells from humans and mice, inflammasome assembly in response to α-hemolysin results in activation of the cysteine proteinase, caspase-1. We also show that inflammasome activation by α-hemolysin works in conjunction with signaling by other CA-MRSA-derived Pathogen Associated Molecular Patterns (PAMPs) to induce secretion of pro-inflammatory cytokines IL-1β and IL-18. Additionally, α-hemolysin induces cell death in these cells through an NLRP3-dependent program of cellular necrosis, resulting in the release of endogenous pro-inflammatory molecules, like the chromatin-associated protein, High-mobility group box 1 (HMGB1). These studies link the activity of a major S. aureus virulence factor to a specific host signaling pathway. The cellular events linked to inflammasome activity have clear relevance to the disease processes associated with CA-MRSA including tissue necrosis and inflammation.
Canadian Gallup Poll # 324
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); family life(2); economic status: city dweller vs. man on the farm(1); Canada in the coming decades(2); chances of world war(2); Canada's Centennial(3); UN job performance(2); common worries(6); general government job performance(1). Note: Demographics(11).
Long Time Tails in Quantum Brownian Motion of a charged particle in a magnetic field
Creators: name: Bhattacharjee, Suraka
name: Satpathi, Urbashi
name: Sinha, Supurna
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We analyse the long time tails of a charged quantum Brownian particle in a harmonic potential in the presence of a magnetic field using the Quantum Langevin Equation as a starting point. We analyse the long time tails in the position autocorrelation function, position-velocity correlation function and velocity autocorrelation function. We study these correlations for a Brownian particle coupled to the Ohmic and Drude baths, via position coordinate coupling. At finite temperatures we notice a crossover from a power-law to an exponentially decaying behaviour around the thermal time scale \frac{\hbar}{K_B T} . We analyse how the appearance of the cyclotron frequency in our study of a charged quantum Brownian particle affects the behaviour of the long time tails and contrast it with the case of a neutral quantum Brownian particle.
description: 10 pages, 3 figures
Canadian Gallup Poll # 325
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); inflation(1); labor leaders taking orders from abroad(1); Prime Minister job performance(1); conservative party(3); 'two nations' policy for Canada(4); war in Vietnam(2). Note: Demographics(11).
Canadian Gallup Poll # 314
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Upcoming federal election: interest, vote intent, electoral behavior(7); past federal elections vote(1); greatest problem facing Canada(2); current party preference(2); inflation(1); government's treatment of farmers(1); majority government(1). Note: Demographics(15). Added: voting eligibility, people over 21 in the household, staying home.
Simple approach to current-induced effects -- bond weakening in metal chains
Creators: name: Papior, Nick
name: Leitherer, Susanne
name: Brandbyge, Mads
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a simple, first principles scheme for calculating mechanical properties of nonequilibrium bulk systems assuming an ideal ballistic distribution function for the electronic states described by the external voltage bias. This allows for fast calculations of estimates of the current-induced stresses inside bulk systems carrying a ballistic current. The stress is calculated using the Hellmann-Feynman theorem, and is in agreement with the derivative of the nonequilibrium free energy. We illustrate the theory and present results for one-dimensional (1D) metal chains. We find that the susceptibility of the yield stress to the applied voltage agrees with the ordering of break voltages among the metals found in experiments. In particular, gold is seen to be the most stable under strong current, while aluminum is the least stable.
Solid argon as a possible substrate for quasi-freestanding silicene
Creators: name: Sattar, S.
name: Hoffmann, R.
name: Schwingenschlögl, U.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the structural and electronic properties of silicene on solid Ar(111) substrate using ab-initio calculations. We demonstrate that due to weak interaction quasi-freestanding silicene is realized in this system. The small binding energy of only $-32$ meV per Si atom also indicates the possibility to separate silicene from the solid Ar(111) substrate. In addition, a band gap of $11$ meV and a significant splitting of the energy levels due to spin-orbit coupling are observed.
Precoding and Decoding Schemes for Downlink MIMO-RSMA with Simultaneous Diagonalization and User Exclusion
Creators: name: Diab, Rouaa
name: Krishnamoorthy, Aravindh
name: Schober, Robert
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we consider the precoder design for downlink multiple-input multiple-output (MIMO) rate-splitting multiple access (RSMA) systems. The proposed scheme with simultaneous diagonalization (SD) decomposes the MIMO channel matrices of the users into scalar channels via higher-order generalized singular value decomposition for the common message (CM) and block diagonalization (BD) for the private messages, thereby enabling low-complexity element-by-element successive interference cancellation (SIC) and decoding at the receivers. Furthermore, the proposed SD MIMO-RSMA overcomes a critical limitation in RSMA systems, whereby the achievable rate of the CM is restricted by the users with weak effective MIMO channel for the CM, by excluding a subset of users from decoding the CM. We formulate a non-convex weighted sum rate (WSR) optimization problem for SD MIMO-RSMA and solve it via successive convex approximation to obtain a locally optimal solution. Our simulation results reveal that, for both perfect and imperfect CSI, the proposed SD MIMO-RSMA with user exclusion outperforms baseline MIMO-RSMA schemes and linear BD precoding.
description: 7pp, 2 figures, accepted to the Workshop on Rate-Splitting Multiple Access for 6G at the IEEE Intl. Commun. Conf. (ICC) 2022
The Set2/Rpd3S Pathway Suppresses Cryptic Transcription without Regard to Gene Length or Transcription Frequency
Creators: name: Nobel, Andrew B.
name: Lieb, Jason D.
name: Shabalin, Andrey A.
name: Strahl, Brian D.
name: Lickwar, Colin R.
name: Rao, Bhargavi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. It was previously reported that this “cryptic” transcription occurs preferentially in long genes, and in genes that are infrequently transcribed. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set2, and applied rigorous statistical methods to identify sites of cryptic transcription at high resolution. We find that suppression of cryptic transcription occurs independent of gene length or transcriptional frequency. Our conclusions differ with those reported previously because we obtained a higher-resolution dataset, we accounted for the fact that gene length and transcriptional frequency are not independent variables, and we accounted for several ascertainment biases that make cryptic transcription easier to detect in long, infrequently transcribed genes. These new results and conclusions have implications for many commonly used genomic analysis approaches, and for the evolution of high-fidelity RNA polymerase II transcriptional initiation in eukaryotes.
NGC 6309, a Planetary Nebula that Shifted from Round to Multipolar
Creators: name: Rubio, Gabriel
name: Vazquez, Roberto
name: Ramos-Larios, Gerardo
name: Guerrero, Martin A.
name: Olguin, Lorenzo
name: Guillen, Pedro F.
name: Mata, Hector
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present new narrow-band Ha, [N II], and [O III] high-resolution images of the quadrupolar planetary nebula (PN) NGC 6309 that show in great detail its bipolar lobes and reveal new morphological features. New high- and low-dispersion long-slit spectra have been obtained to help in the investigation of the new nebular components. The images and spectra unveil two diffuse blobs, one of them located at 55 arcsec from the central star along the NE direction (PA= +71) and the other at 78 arcsec in the SW direction (PA= -151). Therefore, these structures do not share the symmetry axes of the inner bipolar outflows. Their radial velocities relative to the system are quite low: +3 and -4 km/s, respectively. Spectroscopic data confirm a high [O III] to Ha ratio, indicating that the blobs are being excited by the UV flux from the central star. Our images convincingly show a spherical halo 60 arcsec in diameter encircling the quadrupolar nebula. The expansion velocity of this shell is low, 66 km/s. The software SHAPE has been used to construct a morpho-kinematic model for the ring and the bipolar flows that implies an age of 4,000 yrs, the expansion of the halo sets a lower limit for its age 46,000 yrs, and the very low expansion of the blobs suggests they are part of a large structure corresponding to a mass ejection that took place 150,000 yrs ago. In NGC 6309 we have direct evidence of a change in the geometry of mass-loss, from spherical in the halo to axially-symmetric in the two pairs of bipolar lobes.
description: 8 pages, 7 figures, Accepted for publication in MNRAS
Canadian Gallup Poll # 331
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); church/synagogue attendance(1); Quebec's separatism(2); caps on political campaign spendings(1); beliefs(6); Prime Minister job performance(1); higher taxes to help developing countries(1); decriminalizing homosexual behavior(1); labor unions(3). Note: Demographics:(11).
EKO: Evolution Kernel Operators
Creators: name: Candido, Alessandro
name: Hekhorn, Felix
name: Magni, Giacomo
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a new QCD evolution library for unpolarized parton distribution functions: EKO. The program solves DGLAP equations up to next-to-next-to-leading order. The unique feature of EKO is the computation of solution operators, which are independent of the boundary condition, can be stored and quickly applied to evolve several initial PDFs. The EKO approach combines the power of $N$-space solutions with the flexibility of a $x$-space delivery, that allows for an easy interface with existing codes. The code is fully open source and written in Python, with a modular structure in order to facilitate usage, readability and possible extensions. We provide a set of benchmarks with similar available tools, finding good agreement.
description: 24 pages, 10 figures; v2: match to published version
Memoria de investigación 2021: Hospital Universitario Virgen de las Nieves
Creators: name: Flores, Encarnación González
name: Ruiz, Rubén Alba
name: Porcel, María Del Carmen Olvera
name: Ortega, Juan Pérez
name: Mª Del Mar Rodríguez Del Águila
Publisher: name: Zenodo
Year: 2022
Subjects: Investigación
Memoria
Indicadores bibliométricos
Financiación
Ensayos clínicos

description: El HUVN se encuentra dotado de una Cartera de Servicios de alta complejidad, lo que constituye una fortaleza para la investigación de primer nivel, unido a un considerable número de profesionales y grupos investigadores orientados a la investigación e innovación traslacional, epidemiológica y clínica. Los resultados en Investigación en los últimos años (2018-2021) observamos que la evolución ha sido positiva en muchos aspectos, incremento en el número de publicaciones y alto porcentaje de las mismas en revistas Q1. En 2021 el aumento del sumatorio del Factor de impacto del HUVN con respecto 2020 y años anteriores es considerable; el impacto que ha tenido la pandemia de la COVID-19 en las publicaciones científicas, ha aumentado notablemente las citas de las revistas de medicina, cuidados intensivos, salud pública, enfermedades infecciosas, inmunología, etc... con el correspondiente aumento del valor de este indicador a la hora de calcularlo.
description: Memoria de Actividades Científicas del Hospital Universitario Virgen de las Nieves en 2021
A Didactic Model of Macromolecular Crowding Effects on Protein Folding
Creators: name: Tsao, Douglas
name: Dokholyan, Nikolay V.
name: Minton, Allen P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A didactic model is presented to illustrate how the effect of macromolecular crowding on protein folding and association is modeled using current analytical theory and discrete molecular dynamics. While analytical treatments of crowding may consider the effect as a potential of average force acting to compress a polypeptide chain into a compact state, the use of simulations enables the presence of crowding reagents to be treated explicitly. Using an analytically solvable toy model for protein folding, an approximate statistical thermodynamic method is directly compared to simulation in order to gauge the effectiveness of current analytical crowding descriptions. Both methodologies are in quantitative agreement under most conditions, indication that both current theory and simulation methods are capable of recapitulating aspects of protein folding even by utilizing a simplistic protein model.