Additional file 1 of Using Mendelian randomization study to assess the renal effects of antihypertensive drugs
Creators: name: Zhao, Jie V.
name: C. Mary Schooling
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Additional file 1: Table S1. Summary of genome-wide association studies included in this study. Table S2. Genetic predictors for different classes of antihypertensives. Table S3. Associations of genetic proxies for antihypertensive drugs with eGFR in meta-analysis of UK Biobank and CKDGen incorporating correlated genetic variants. Table S4. Associations of genetic proxies for antihypertensive drugs with UACR in CKDGen incorporating correlated genetic variants. Table S5. Associations of genetic proxies for antihypertensive drugs with albuminuria incorporating correlated genetic variants. Table S6. Genetic predictors with potential pleiotropy. Table S7. Sensitivity analysis for the association with eGFR excluding potentially pleiotropic genetic predictors. Table S8. Sensitivity analysis for the association with UACR and albuminuria excluding potentially pleiotropic genetic predictors. Table S9. Sensitivity analysis on the associations of genetic proxies for antihypertensive drugs with eGFR using published genetic variants derived from UK Biobank in Mendelian randomization using different analysis methods. Table S10. Sensitivity analysis on the associations of genetic proxies for antihypertensive drugs with albuminuria and UACR using genetic variants derived from UK Biobank in Mendelian randomization using different analysis methods. Figure S1. Comparison using different sets of genetic proxies for ACE inhibitors, CCBs and BBs. (a) for eGFR, (b) for UACR, (c) for albuminuria. Black square refers to using genetic variants based on the study of Walker et al. [11] in UK Biobank, grey circle refers to using genetic variants based on the study of Gill et al. [12] and Georgakis and Gill et al. [16] in meta-analysis of UK Biobank and ICBP. Figure S2. Associations of genetic proxies for antihypertensive drugs with eGFR by drug target in each drug class, overall antihypertensives and systolic blood pressure. SBP, systolic blood pressure. ACE, Angiotensin-converting enzyme; ARB, Angiotensin II Receptor Blocker; BBs, beta-adrenoceptor blockers; CCBs, calcium channel blockers; PSDs, potassium-sparing diuretics; SBP, systolic blood pressure. Figure S3. Associations of genetic proxies for antihypertensive drugs with UACR by drug target in each drug class, overall antihypertensives and systolic blood pressure. ACE, Angiotensin-converting enzyme; ARB, Angiotensin II Receptor Blocker; BBs, beta-adrenoceptor blockers; CCBs, calcium channel blockers; PSDs, potassium-sparing diuretics; SBP, systolic blood pressure. Figure S4. Associations of genetic proxies for antihypertensive drugs with albuminuria by drug target in each drug class, overall antihypertensives and systolic blood pressure. BBs, beta-adrenoceptor blockers; CCBs, calcium channel blockers; PSDs, potassium-sparing diuretics; SBP, systolic blood pressure.