cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of Sox8 and Ndp as Novel Targets of the Hedgehog Signaling Pathway in the Retina
Creators: name: McNeill, Brian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: retina
development
Sonic hedgehog
proliferation

description: During embryonic development, the Hedgehog (Hh) signaling pathway plays an important role in the growth and patterning of numerous tissues and organs. In the developing retina, Hh signaling regulates the proliferation and differentiation of retinal progenitor cells (RPC) through mechanisms that are not completely understood. The principal downstream mediators of the Hh pathway are the Gli transcription factors (Gli1-3), which regulate the expression of target genes responsible for the effects of the Hh pathway on RPC. The network of genes targeted by this pathway in neural progenitor cells however, remains unknown. The objective of this thesis was to identify and characterize novel targets of Hh/Gli during retinal development. Using a computation approach, 390 genes were identified as having at least one conserved Gli binding motif within the vicinity of the coding sequence between humans and mice. During validation, I demonstrate that 30 of 46 selected targets were modulated in response to Hh pathway activation in either E14.5 and/or P0.5 retinal explants and that the induction of 25 of these were significantly different between the two developmental stages. Included in this list of Hh-modulated genes were Sox8 and Ndp, two highly inducible genes that are direct targets of Gli2. Functionally, I was unable to determine a role for Sox8 during retinal development which could reflect compensation by the closely related Sox9 and Sox10 genes. Ndp on the other hand was found to be sufficient and required for Hh mediated induction in progenitor cell proliferation and cell fate determination. Therefore, in this thesis Hh target genes have been identified which could provide some insight into the mechanisms that are responsible for the cellular outcome of a response to the pathway.
Les causes de l'abstentionnisme électoral
Creators: name: Souissi, Hamdi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Démocratie
Participation politique
Institutions
Rationalité
Sociologie politique

description: Cette thèse cherche à élucider le mystère de la désertion civique alors que la démocratie semble triompher un peu partout. Elle débute par un examen des institutions démocratiques modernes et leur conformité aux principes défendus par l'idéal démocratique. Face à ce décalage, le comportement individuel et les processus rationnels de décision seront analysés. Le champ d'analyse s'élargira à travers l'examen des déterminants sociaux et de leur impact sur la participation globale. Finalement, seront examinées les institutions et les systèmes afin de voir dans quelle mesure ils influent les comportements politiques. Cela mènera à une conclusion qui s'articulera autour de l'idée d'une rationalité "perçue" où les individus font des calculs stratégiques mais tout en demeurant restreints par des facteurs sociaux qu'ils ne contrôlent pas.
Student Discipline and Neoliberal Governance: A Critical Criminology of Education
Creators: name: Guebert, Karl
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Criminology of education
Critical criminology
Governance
Regulation

description: Prompted by the need to expand the criminological enterprise, I put forward a criminology of education that offers a deeper understanding of education’s purpose in contemporary society. In tracing the reconfiguration of social security and understandings of citizenship in Western capitalist societies, education is situated as a centrally important institution of social governance. Moving from ‘the social’ as the predominant category of governance to smaller, individualized units of governance such as the ‘community’ has produced a post-social state which involves significant implications for political institutions, including crime control and education. This is illustrated by the ‘criminalization of schools’ thesis, which posits that schools increasingly take on responsibilities for governing crime to the point that they are now governed through crime. Market preparation constitutes another governing principle of education, encapsulated in what can be termed the ‘marketization of schools’, which points to education’s role in producing lean, active citizens. I draw on the work of Michel Foucault and Pierre Bourdieu for explicating the features of governance and discipline, and their articulation. I then turn to explore the empirical referent found in recent efforts to rethink and reorganize student discipline policies in Ontario schools. The ‘discovery’ of bullying in Ontario is suggested to be a discursive reality that made possible the implementation of a program of regulation. From this, we see that education is conceptualized and represented as a ‘security apparatus’, and education policies as increasingly concerned with managing public safety and social order.
An exploratory study of recharging mechanisms in a shared service context
Creators: name: Lu, Ye
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business

description: It is claimed that the transformation of business support services through some form of ‘externalization’ mechanism such as the shared service centre (SSC) model can drive down costs and enhance functionality. A key characteristic of the SSC’s rationale is its ability change by replicate the characteristics of third-party outsourcing, whilst also retaining overall management control within the boundaries of the organization. In such a market-oriented model, it should follow that a key feature of an SSC is the recharging of its costs to its customers, the business facing operational units. Yet, in offering a hybrid solution combining characteristics of market and hierarchy, it could be expected that the recharging for support services will seek to combine the tenets of both market-orientated transfer pricing with cost allocation methods traditionally associated with internal cost centres. The motivation of this study is the increasing prevalence of the SSC model amongst large organizations in the face of a relative paucity of contemporary literature on transfer pricing and cost allocation in new organizational forms, especially the SSC model. The central theme of this study is to explore the recharging mechanisms applied by different SSCs and their organizational effects in terms of balancing market coordination between the SSC and its customers and top management control. Three case studies were undertaken to explore how SSCs recharge the costs for the finance function as a business support services and the effects on managerial behaviours of both the SSC and business units. Drawing on theory of organizational structure, transaction cost economics (TCE) and agency theory, a conceptual framework was constructed to guide the analysis of the empirical evidence. The findings of this study include: 1) The choice of recharging method can be either transfer pricing approach (direct recharge) or cost allocation (indirect recharge), contingent upon; the governance orientation of each organization, asset specificity and extent of transactions, uncertainty and opportunism and bounded rationality. 2) Mandating the choice of recharging mechanism given the asymmetric bargaining power between the SSC and the head office could cause agency problems within the organizations, although this could be mitigated by transparency of information, appropriate coordination mechanisms, and performance measurement based on mutually agreed budget targets. 3) Recharging mechanism is fluid over time and in one of the cases (i.e. DHL Express) it is found that the transfer pricing can be used in the first stages of SSC implementation to drive change, but on maturity there is a reversion to broad brush cost allocation to better enable overall system optimization with reduced transaction costs.
E-government and the Transformation of Public Administration in Developing Countries: A Case Study of the Kenya Revenue Authority
Creators: name: Kerandi, Andrew Maranga
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: E-Government
Public Administration
Transformation

description: One question that continues to occupy the minds of scholars of e-government is whether information and communication technologies (ICT) can transform public administration. General opinion on the subject is sharply divided: some believe that e-government can shape public administration, while others doubt that it can have this effect. At the empirical level, the testing of the influence of e-government on public administration has been largely ignored. Consequently, the fundamental question remains unanswered, as do the further questions of precisely how and with what effects might information and communication technologies be reshaping public administration. These are the questions that motivated the research presented here, which examines and describes the transformative powers of e-government by focusing on the use of information and communication technologies to transform a particular public agency, the Kenya Revenue Authority. The research used two main methods of data collection and construction: interviewing senior management at the Kenya Revenue Authority (KRA) and reviewing documents obtained from the KRA and other public sources. A transformation change analytical framework was used to analyze the KRA before the implementation of ICT-enabled reforms as an organization needing change and after these reforms as a transformed organization. The results of the findings suggest that, although ICT has had some beneficial effects on the KRA, the changes produced to date fall short of being described as transformative. While the KRA has experienced significant improvements in performance in terms of revenue, it has yet to fully integrate its operations, change its organizational structure to achieve optimal efficiency, or transform the organizational behaviour and culture of its staff in ways that improve its operations or enhance its public image.
Person-centred care in practice: perspectives from a short-course regimen for multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan: A qualitative study
Creators: name: Horter, Shona
name: Stringer, Beverley
name: Gray, Nell
name: Parpieva, Nargiza
name: Khasan Safaev
name: Tigay, Zinaida
name: Singh, Jatinder
name: Achar, Jay
Publisher: name: F1000 Research Limited
Year: 2020

description: Person-centred care in practice: perspectives from a short-course regimen for multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan: qualitative study presented at MSF Scientific Days International (London) Medical Research Day, May 13, 2020 by Shona Horter
Regulation of Myoplasmic Ca2+ During Fatigue in KATP Channel Deficient FDB Muscle Fibres
Creators: name: Selvin, David
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: muscle
katp
katp channel
calcium
verapamil
nac
ros
reactive oxygen species
n-acetyl cysteine
glibenclamide
atp
sarcomere
physiology
fatigue
FDB
single fibre
fibre
fiber
tension
collagenase digestion
mem
dmem
fbs
fetal bovine serum

description: It is known that muscles that lack KATP channel activity generate much greater unstimulated [Ca2+]i and force than normal muscles during fatigue. The increase in unstimulated force in KATP channel deficient muscles is abolished by a partial inhibition of L-type Ca2+ channels, suggesting that it is due to a Ca2+ influx through L-type Ca2+ channels and a subsequent increased myoplasmic Ca2+. However, there is also evidence that the increase in resting force is abolished by NAC, a ROS scavenger. The objective of this study was to reconcile these observations by studying the hypothesis that “the increase in resting [Ca2+]i during fatigue in KATP channel deficient muscles starts with an excess Ca2+ influx through L-type Ca2+ channels, followed by an excess ROS production that causes a further increase in resting [Ca2+]i”. To test the hypothesis, single FDB fibres were fatigued with one tetanic contraction/sec for 180 sec. KATP channel deficient fibres were obtained i) by exposing wild type muscle fibers to glibenclamide, a KATP channel blocker and ii) by using fibres from Kir6.2-/- mice, which are null mice for the Kir6.2 gene that encodes for the protein forming the channel pore. Verapamil, a L-type Ca2+ channel blocker, applied at 1 μM, significantly reduced resting [Ca2+]i during fatigue in glibenclamide-exposed wild type fibres. NAC (1 mM) also reduced resting [Ca2+]i in glibenclamide-exposed muscles. The results suggest that the increase in resting [Ca2+]i during fatigue in KATP channel deficient FDB fibres is due to an influx through L-type Ca2+ channels, and an excess ROS production.
Atomizzata o connessa? L’agire politico nella società individualizzata tra de-politicizzazione e ri-politicizzazione
Creators: name: Raffini, Luca
name: Pirni, Andrea
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2019

description: The article analyzes the relationship between social change and political change. The basic thesis is that, behind the widespread diagnosis of a political crisis a silencing "re-elaboration of the political" is happening. It’s a qualitative transformation of the places, of the actors, of the meanings of participation and, by this way, of the very definition of what is "political" that is deeply rooted in the "reinvention of the social". Social change profoundly alters the relationship between the individual and the collective sphere and transforms the role and functioning of political institutions. As a result, the forms and aims of participation are profoundly transformed. The "reinvention of the social" is a process of radical redefinition of the modalities of sociability between individuals and of the relationship between the individual and the collective sphere. The re-elaboration of the political, which finds expression in innovative practices of participation, promotes a process of re-politicization, which goes hand in hand with the process of de-politicization. Individualization does not mean atomization. It does not equate with depoliticization and it does not necessarily translate into eclipses of the public dimension and political solitude. The contribution suggests that the re-elaboration of politics is rooted in a “connected individualism”, while political solitude is expression of a “atomized individualism”.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol 9 No 17 (2019): Political Solitude
Electrophysiological Investigations on the Role of Selected Serotonin Receptors and the Serotonin Transporter on Serotonin Transmission in the Rat Brain
Creators: name: Lecours, Maurice
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Depression
Vortioxetine
Hippocampus
Electrophysiology
Serotonin
Lu AA21004
Multimodal Antidepressant

description: This study assessed the in vivo effects of various serotonin (5-HT) receptor modulators on 5-HT neurotransmission in the rat hippocampus. Vortioxetine, humanized-vortioxetine, and escitalopram blocked the 5-HT transporter, but similar to ipsapirone did not dampen the sensitivity of postsynaptic 5-HT1A receptors. Long-term administration of all treatments increased the tonic activation of postsynaptic 5-HT1A heteroreceptors, an effect common to all antidepressants. Vortioxetine decreased the function of the terminal 5-HT1B autoreceptor under high but not a low degree of activation, thus showing that its partial agonism led to increased 5-HT release and that long-term administration results in the desensitization of terminal 5-HT1B autoreceptors. Vortioxetine overcame the effects of 5-HT1B and 5-HT3 receptor agonists. This study was unable to determine the involvement of 5-HT7 receptor antagonism exerted by vortioxetine affects 5-HT neurotransmission. Therefore, vortioxetine would appear to exert different actions, via transporter and receptor activity, on the serotonergic system in the hippocampus, consistent with its unique pharmacological profile.
A proactive approach for managing COVID-19 : The importance of understanding the motivational roots of vaccination hesitancy for SARS-CoV2
Creators: name: Taylor, Steven, 1960-
name: Landry, Caeleigh A.
name: Paluszek, Michelle M.
name: Groenewoud, Rosalind
name: Rachor, Geoffrey S.
name: Asmundson, Gordon J. G.
Publisher: name: Frontiers
Year: 2021

description: Importance: Vaccination hesitancy—the reluctance or refusal to be vaccinated—is a leading global health threat (World Health Organization, 2019). It is imperative to identify the prevalence of vaccination hesitancy for SARS-CoV2 in order to understand the scope of the problem and to identify its motivational roots in order to proactively prepare to address the problem when a vaccine eventually becomes available. Objective: To identify (1) the prevalence of vaccination hesitancy for a SARS-CoV2 vaccine, (2) the motivational roots of this hesitancy, and (3) the most promising incentives for improving the likelihood of vaccination uptake when a vaccine does become available. Design, Setting, and Participants: A cross-sectional sample of 3,674 American and Canadian adults assessed during the COVID-19 pandemic in May 2020. Main Outcomes: Measures of vaccination intention (i.e., “If a vaccine for COVID-19 was available, would you get vaccinated?”), attitudes toward vaccines in general and specific to SARS-CoV2 using the Vaccination Attitudes Examination Scale, and incentives for getting vaccinated for those who reported they would not get vaccinated. Results: Many American (25%) and Canadian (20%) respondents said that they would not get vaccinated against SARS-CoV2 if a vaccine was available. Nonadherence rates of this magnitude would make it difficult or impossible to achieve herd immunity. Vaccine rejection was most strongly correlated with mistrust of vaccine benefit, and also correlated with worry about unforeseen future effects, concerns about commercial profiteering from pharmaceutical companies, and preferences for natural immunity. When asked about incentives for getting vaccinated, respondents were most likely to report that evidence for rigorous testing and safety of the vaccine were of greatest importance. Conclusions and Relevance: Vaccination hesitancy is a major looming problem for COVID-19. To improve vaccine uptake, it is imperative that the vaccine is demonstrated to the public to be rigorously tested and not perceived as rushed or premature in its dissemination.
Accumulating Cares: Women, Whiteness, and the Affective Labour of Responsible Reproduction in Neoliberal Times
Creators: name: Watson, Amanda
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: care work
labour
reproduction
citizenship
responsibility
motherhood
gender
whiteness
feminist political theory
affect
representation

description: This thesis examines contemporary popular and news media representation of motherhood and labour in Canada and the United States. I explore what texts about motherhood and maternal labour suggest about gendered responsibilities to citizenship in neoliberal conditions. Building on important feminist research in the fields of citizenship, care, and the welfare state, I ask how are mothers being socially responsibilized toward multiple forms of labour simultaneously and to what effect? By engaging feminist theories of citizenship and bridging this field with feminist theories of science, media, and affect, I demonstrate how, under neoliberal conditions and in precarious circumstances, the ways in which women appear to juggle their commitments to paid and unpaid labour, determines how mainstream discourses reflect their value as citizens. This dissertation uses feminist critical discourse analysis to assess how, as women are responsibilized toward unpaid intimate work in newly empirical ways at the same time that they are encouraged to pursue career success in full-time paid employment, contemporary women in Canada and the United States are encouraged to rise above welfare retrenchment and inadequate provision by juggling “it all.” My thesis is an intersectional feminist project that interrogates questions of gendered citizenship and maternal affect, and I join feminist political theorists in applying pressure to the field of citizenship studies to centre reproduction in discussion of gendered welfare.
Lärmbilanz 2015
Creators: name: Heinrichs, Eckhart
name: Kumsteller, Falk
name: Rath, Sibylle
Publisher: name: My University
Year: 2016
Subjects: subject: Lärm
subject: EU-Umgebungslärmrichtlinie
subject: Lärmaktionsplan
subject: Information der Öffentlichkeit
subject: Öffentlichkeitsbeteiligung
subject: Lärmkarten
subject: ruhige Gebiete
subject: Beteiligung der Öffentlichkeit
subject: Lärm
subject: Transport

description: Das Vorhaben analysiert die Meldungen der Bundesländer zur Lärmkartierung und zur Lärmaktionsplanung. Zu diesem Zweck wurden zunächst die beim Umweltbundesamt vorliegenden Daten übernommen, gesichtet und auf Plausibilität, Doppelungen usw. geprüft. Im vorliegenden Bericht werden die Ergebnisse mittels deskriptiver Statistik beschrieben und hinsichtlich möglicher Zusammenhänge zwischen einzelnen Aspekten analysiert. Im Ergebnis wird ein aktueller Überblick über die Lärmaktionsplanung der zweiten Stufe in Deutschland gegeben. Ausgewählte Daten werden mit denen der ersten Stufe (Lärmbilanz 2010) verglichen.
Exploring Elite Soccer Players' Attentional Focus in Performance Tasks and Game Situations
Creators: name: Alves Ballón Tedesqui, Rafael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Soccer
Attentional focus
Elite athletes
Performance tasks

description: The purpose of this study was to investigate elite soccer players' attentional focus during their best performances, better understand the strategies they use to enter or re-enter optimal attentional states, and explore potential attentional differences according to soccer positions, performance tasks, and game situations. No previous studies have explored elite soccer players' attentional skills from a naturalistic and qualitative perspective in such detail. The growing interest in soccer among Canadians provided further justification for this study. Data collection consisted of individual semi-structured interviews with eight elite soccer players from five main soccer positions, namely goalkeeper, defender, wing, midfielder, and forward. Cross-case thematic analysis indicated positive thinking and pre-performance routines as important sources of optimal focus. Attentional focus varied according to soccer positions and performance tasks. Information processing, sport expertise, and attentional systems theoretical frameworks informed the discussion of results. Applied and theoretical implications were drawn and future studies were recommended.
Dependence of drag coefficient on the directional spreading of ocean waves
Creators: name: Ting, Chia-Huan
name: Babanin, Alexander
name: Chalikov, Dmitry
Publisher: name: Swinburne
Year: 2024

description: Drag coefficient Cd is one of the most important properties used in modelling the air-sea interactions. Most of the dependences employ the sea drag as a function of wind speed U10. Coupling between the atmospheric boundary layer and the ocean surface is usually parameterised in terms of the drag coefficient Cd , T=Pau2=paC10U210 (1) , where where T is the wind stress at the ocean surface, Pa is the air density, U10 is the wind speed measured at standard 10m height and u is the friction velocity. Routinely, C10 is parameterized as a function of mean wind speed U10, but the scatter of experimental data around such parametric dependences is very significant and has not improved noticeably over some 30 years. This scatter imposes a serious limitation on predictions that make use of seasurface-drag parameterisations. Babanin and Makin (2008) suggested that, apart from the wind speed, C10 depends on a number of other physical properties and phenomena, whose effect on the sea drag should be investigated and incorporated in the final parameterisation in order to reduce the scatter. These properties include, among possible others, the directional spreading of the surface waves. The aim of the present study is to investigate the drag coefficient as a function of such angular spreading. This will be first done by means of numerical modelling with WBLM (Wave Boundary Layer Model, Chalikov and Rainchik, 2010). 1-D equations derived by Chalikov and Rainchik are used here for extensive calculations of WBL structure in order to investigate dependence of the drag coefficient on wind speed for different directional wave spectra. The results will then be compared with the field measurements conducted during the Lake George experiment (Young et al., 2005, Babanin and Makin, 2008). In the Conclusion, we should say that the wind speed is not the only a parameter which can influence the sea drag coefficient. In particular, in this paper dependence of C10 on directional spreading of surface waves was investigated. It is shown that this coefficient increases with higher directional widths and stronger wind forcing. Influence of the wave directional spectrum on the sea drag was analysed for the first time, and it is very essential. Comparisons show that the WBL Model and Lake George field experimental data agree, where available, and this fact supports the model and the analysis of sea-drag dependences and asymptotic behaviours. Account for the directional spread is therefore essential to predict the sea drag accurately and to improve parameterisations of C10. It is apparent that scatter of existing parameterisations cannot be reduced by increasing measurement accuracy; it needs understanding and parameterising multiple physical influences, including the wave directionality.
Two-way Approach to Spinal Muscular Atrophy Therapy Development
Creators: name: Goulet, Benoit
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Spinal Muscular Atrophy
Gene Therapy
Adenovirus

description: Spinal muscular atrophy (SMA) is the most commonly inherited neurodegenerative disease that leads to infant mortality worldwide. There are no known cures for SMA, but small increase in protein levels of SMN can be beneficial. We have developed adenoviral (Ad) vectors that express a human transgene of SMN and have tested their safety in vitro. We have demonstrated that these viruses can effectively express the transgene following cell entry and that the levels are relative to the virus dose. The viruses do not appear to impact the health and function of the cells, and are capable of increasing the number of Gems. We also attempted to change the tropism of the viruses through fiber protein modifications in order to target muscles and motor neurons. Our results suggest that a therapy based on an Ad-SMN fiber-modified vector may ultimately be successful in treating patients of SMA.
An Examination of the Prostitution Debate in Action: ‘Unpacking’ the Discourses, Convergences, and Divergences in Bedford
Creators: name: Ruthven, Brittany
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Bedford
Prostitution
Sex Work
Prostitutes
Sex Workers
Supreme Court of Canada
Customers
Third parties
Risk
Choice

description: Prostitution, sex in exchange for consideration, has never been illegal in Canada; however, activities surrounding prostitution have been criminalized in the Criminal Code. These prohibited activities include: working indoors (s. 210 keeping a common bawdy house), providing services to sex workers (s. 212(1)(j) living off of the avails of prostitution), and communicating in public for the purposes of prostitution (s. 213). In 2007 two former and one current sex worker, Terri Jean Bedford, Valerie Scott and Amy Lebovitch challenged the constitutionality of the above laws, arguing that they increased sex workers’ vulnerability to harm. Six years later on June 13th, 2013 the Supreme Court of Canada heard the landmark case Canada (Attorney General) v. Bedford. Prior to hearing the case, the Supreme Court Justices read the submitted factums outlining the arguments of the appellants, respondents, and their interveners. The final decision was released on December 22nd, 2013 and the unanimous decision to strike down all three laws was made. Using a discourse analysis inspired by Michel Foucault, this study ‘unpacks’ the meanings that are constituted within the factums submitted to the Supreme Court regarding the people who engage in sex work and the institution of prostitution. The convergences and divergences within the discourses are presented. Drawing on these findings, while applying the work of Wedeking’s (2010) strategic legal framing alongside the governmentality perspective of risk, the tensions surrounding risk and choice are further explored. In doing so, the relationship between risk (taking/avoiding) and choice (making) is teased out. In this thesis I argue that risk and choice are strategically framed in the submitted factums to demonstrate the (un)constitutionality of Canada’s prostitution laws. Furthermore, I argue that both the appellants and respondents agree that risk avoidance is an acceptable self-governance strategy for sex workers, however they diverge on what they consider to be acceptable risk avoidance measures. The conclusion of this study discusses the decision of Canada (Attorney General) v. Bedford to strike down the three prostitution laws and the subsequent introduction of the Protection of Communities and Exploited Persons Act.
Transformed Random Walks
Creators: name: Forghani, Behrang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Poisson boundary
Random walks on groups
Stopping times
Entropy
Drift

description: We consider transformations of a given random walk on a countable group determined by Markov stopping times. We prove that these transformations preserve the Poisson boundary. Moreover, under some mild conditions, the asymptotic entropy (resp., rate of escape) of the transformed random walks is equal to the asymptotic entropy (resp., rate of escape) of the original random walk multiplied by the expectation of the corresponding stopping time. This is an analogue of the well-known Abramov's formula from ergodic theory.
Unveiling The Secrets of Hindgut Fermentation: Alternative Sites of Microbial Digestion
Creators: name: Dr. Arumbaka Sudheer babu1, Dr. N. Prathith2
Publisher: name: The Science World a monthly e magazine
Year: 2024

description: Hindgut fermentation, a microbial digestive process occurring in the large intestine, has emerged as a vital component of nutrient extraction and energy production in various animal species. This review explores the mechanisms, benefits, and significance of hindgut fermentation in alternative sites of microbial digestion, including the cecum, colon, and distal small intestine. Our analysis reveals that hindgut fermentation enhances nutrient extraction, produces short-chain fatty acids, and modulates the immune system, contributing to improved gut health and animal productivity. We examine the importance of hindgut fermentation in different animals, including horses, pigs, and humans, highlighting its role in maintaining a healthy gut microbiome. This review provides new insights into the complex interactions between the host animal and its microbiome, underscoring the need for further research into the applications of hindgut fermentation in animal nutrition and health. By recognizing the significance of alternative sites of microbial digestion, we can unlock new strategies for improving animal health, productivity, and sustainability.
Supplementary document for Fundamental Challenges and Optimization Guidelines of Geometric Phase Metasurfaces with Broken Rotation Symmetry - 5414793.pdf
Creators: name: Zhang, Jinrun
name: Zeng, Jinwei
name: Liu, Yangjie
name: Dong, Yajuan
name: Wang, Jian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: All the supplementray informationa are in this filed
Construction and Characterization of Gene Regulatory Networks in Yeast
Creators: name: Jedrysiak, Daniel K.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: gene
regulatory
network
synthetic biology
yeast
DNA
cloning
BrickMason
GRN
CYC8
TUP1
SSN6

description: Two major roadblocks in synthetic biology are the difficulties associated with the physical assembly of gene regulatory networks (GRNs) and the lack of characterized biological parts. In this work we aimed to address both of these issues. We developed a novel method for the assembly of GRNs called Brick- Mason assembly. We have shown that the method can assemble a 6 part network in a single day and provides significant advancements over traditional cloning methods. We used BrickMason to assemble GRNs that would allow us to compare natural yeast mechanisms of repression to the steric hindrance based mechanisms that are commonly used in synthetic GRNs in yeast. Our results show that the two mechansisms of repression are not equivalent. This finding opens possibilities for using a new class of repressor in a synthetic context in yeast.
Étude des déterminants des transferts de fonds de la diaspora indo-canadienne : variables et indicateurs pertinents
Creators: name: Laurin-Gordon, Mathieu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Inde
Diaspora
Indo-canadien
Transferts de fonds

description: Chaque année, des milliers d’Indo-Canadiens envoient des sommes considérables du Canada vers l’Inde. Ces flux, mieux connus sous le nom de transferts de fonds (TDF), ont connu une croissance soutenue et ce, même depuis la crise économique mondiale de 2008. Or, que savons-nous des raisons qui motivent ces transferts de fonds du pays d’accueil vers le pays d’origine, et plus spécifiquement en ce qui concerne la diaspora indo-canadienne (DIC)? L’objectif de la présente recherche est de proposer un cadre opératoire et des pistes de recherche qui permettent de jeter les bases d’une étude qualitative de plus grande ampleur sur le sujet. Pour développer notre grille, nous recensons et analysons de façon critique la littérature portant sur les déterminants des TDF. Nous élaborons ensuite un profil socioéconomique, socioprofessionnel et historique de la DIC. Nous arrivons à la conclusion que quatre variables importantes doivent être étudiées et proposons un certain nombre d’indicateurs afin d’y arriver. Il s’agit des variables migration, famille, attachement familial et attachement au lieu d’origine.
Omissions and additions: ethics and the epistolary writer
Creators: name: Whitting, Glenice Joy
Publisher: name: Swinburne
Year: 2024

description: Contemporary creative epistolary writers can become confused when confronted with ethical issues relating to genre naming such as creative nonfiction; faction; autobiofiction, the nonfictional novel, ethnographic fiction and true fiction. These hybrid forms often do not require a human research ethics formal clearance, however, these stories must still show strong evidence of ethical interrogation. During the writing of the epistolary novel, Hens lay, people lie, many ethical issu·es emerged. The main four being: ethical treatment of people, my responsibility to myself as a writer, the contract between writer and reader and my responsibility to the novel. The connection between the ethical issues of women's writing and informal, creative forms of writing, such as diaries, journals and personal letters, will be the focus of this paper.
Inner Ensembles: Using Ensemble Methods in Learning Step
Creators: name: Abbasian, Houman
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Inner Ensemble Bayesian Network
Inner Ensembles
Bayesian Network
K-Means
Inner K-Means

description: A pivotal moment in machine learning research was the creation of an important new research area, known as Ensemble Learning. In this work, we argue that ensembles are a very general concept, and though they have been widely used, they can be applied in more situations than they have been to date. Rather than using them only to combine the output of an algorithm, we can apply them to decisions made inside the algorithm itself, during the learning step. We call this approach Inner Ensembles. The motivation to develop Inner Ensembles was the opportunity to produce models with the similar advantages as regular ensembles, accuracy and stability for example, plus additional advantages such as comprehensibility, simplicity, rapid classification and small memory footprint. The main contribution of this work is to demonstrate how broadly this idea can be applied, and highlight its potential impact on all types of algorithms. To support our claim, we first provide a general guideline for applying Inner Ensembles to different algorithms. Then, using this framework, we apply them to two categories of learning methods: supervised and un-supervised. For the former we chose Bayesian network, and for the latter K-Means clustering. Our results show that 1) the overall performance of Inner Ensembles is significantly better than the original methods, and 2) Inner Ensembles provide similar performance improvements as regular ensembles.
Physiological Response of Populus balsamifera and Salix eriocephala to Salinity and Hydraulic Fracturing Wastewater: Potential for Phytoremediation Applications
Creators: name: Bilek, Michael
name: Soolanayakanahally, Raju Y.
name: Guy, Robert D.
name: Mansfield, Shawn D., 1969-
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Natural and anthropogenic soil degradation is resulting in a substantial rise in the extension of saline and industrially-polluted soils. Phytoremediation offers an environmentally and economically advantageous solution to soil contamination. Three growth trials were conducted to assess the stress tolerance of native Canadian genotypes of Populus balsamifera L., Salix eriocephala Michx., and one hybrid willow (S. discolor × S. dasyclados) to salinity and hydraulic fracturing (fracking) wastewater. Thirty-three genotypes were grown in NaCl or fracking wastewater solutions between 0 and 7 mS⁻¹ over a period of 3–4 months. P. balsamifera was observed to be relatively salt-intolerant compared to S. eriocephala and hybrid willow, which is likely caused by an inability of P. balsamifera to restrict Na+ translocation. Photosynthesis and transpiration decreased with salinity treatments, and severe reductions occurred with exposure to fracking solutions. Raffinose and stachyose content was tripled in leaf and root tissues. In willows, Na+ was primarily confined to root tissues, Cl⁻ accumulated up to 5% dry weight in leaves, and K⁺ was translocated from roots to leaves. Willow genotypes CAM-2 and STL-2 displayed the greatest maintenance of growth and resistance to necrotic symptoms in all trials, suggesting that these genotypes may be useful for practical application and further field study.
The Canadianisation of the Holocaust: Debating Canada's National Holocaust Monument
Creators: name: Chalmers, Jason
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Holocaust memory
Holocaust monuments
collective memory
Canadian identity
Jewish identity
Canadian Jews
minorities in Canada
nationalization

description: Holocaust monuments are often catalysts in the ‘nationalization’ of the Holocaust – the process by which Holocaust memory is shaped by its national milieu. Between 2009 and 2011, the Parliament of Canada debated a bill which set out the guidelines for the establishment of a National Holocaust Monument (NHM), which ultimately became a federal Act of Parliament in early 2011. I examine the discourse generated by this bill to understand how the memory of the Holocaust is being integrated into the Canadian identity, and argue that the debate surrounding the NHM has been instrumental in the ‘Canadianisation’ of the Holocaust. I summarise my findings by placing them into dialogue with other national memories of the Holocaust, and identify three distinct features of Holocaust memory in Canada: a centrifugal trajectory originating in the Jewish community, a particular-universal tension rooted in multiculturalism, and a multifaceted memory comprising several conflicting – though not competing – narratives. Monuments de l’Holocauste sont souvent des catalyseurs de la «nationalisation» de l'Holocauste – le processus par lequel mémoire de l'Holocauste est formé par son milieu national. Entre 2009 et 2011, le Parlement du Canada a débattre un projet de loi qui crée les lignes directrices pour la mise en place d'un Monument national de l'Holocauste (MNH), qui est finalement devenu une loi fédérale du Parlement au début de 2011. J'examine le discours généré par ce projet de loi pour comprendre comment la mémoire de l'Holocauste est intégrée dans l'identité canadienne, et soutien que le débat entourant le MNH a joué un rôle déterminant dans la «canadianisation» de l'Holocauste. Je résume mes conclusions en les plaçant dans le dialogue avec d'autres mémoires nationales de l'Holocauste, et d'identifier trois caractéristiques distinctes de mémoire de l'Holocauste au Canada: une trajectoire centrifuge d’origine dans la communauté juive, une tension particulière-universelle enracinée dans le multiculturalisme, et une mémoire à multiples facettes comprenant plusieurs récits contradictories – mais pas compétitifs.
The Role of Cdx in Primitive Hematopoiesis
Creators: name: Brooke-Bisschop, Travis
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014

description: Functional overlap and peri-implantation lethality have made the study of the Cdx family of transcription factors a challenging pursuit. Our research group has generated a conditional genetic knockout model that renders the murine embryo effectively Cdx null, allowing us to explore unknown developmental roles of Cdx. Previously uncharacterized hematopoietic defects are evident in these embryos, and with the use of ChIP-seq technology, a number of hematopoietic genes were identified as putative Cdx targets, including Scl, Lyl1, Lmo2, and Meis1. In addition, the chromatin remodeling protein Brg1 was identified from a SILAC-MS screen of potential Cdx2 interactors, and was studied in the context of direct interaction with Cdx2. My studies suggest a critical role for Cdx in primitive hematopoiesis in mice, and indicate that Cdx2 may recruit Brg1 to specific targets to induce transcription of these genes. // L'étude des facteurs de transcription Cdx est difficile principalement à cause de la létalité péri-implantation de la perte de Cdx, ainsi que ces facteurs partagent plusieurs fonctions. Notre groupe a généré un modèle de KO génétique conditionnel qui rend l'embryon murin efficacement Cdx nul, ce qui nous permet d'explorer les rôles de développement inconnus de Cdx. Précisément, on a vu des défaits hématopoïétiques dans ces embryons, et avec l'utilisation de la technologie « ChIP-seq », un certain nombre de gènes hématopoïétiques ont été identifiés comme gènes cibles de Cdx putatifs, dont Scl, Lyl1, Lmo2, et Meis1. En outre, on a identifié Brg1, un protéine de remodelage de la chromatine, à partir d'un écran SILAC-MS de interacteurs Cdx2 potentiels. Dans ce regard, on a étudié interaction directe entre Cdx2 et Brg1. Mes études suggèrent un rôle critique pour Cdx dans l'hématopoïèse primitive chez la souris, et indiquent que Cdx2 peut recruter Brg1 à des cibles spécifiques pour induire la transcription de ces gènes.
title: To evaluate association of breast arterial calcification with coronary CTcalcium score to see if breast arterial calcification correlates with increased cardiovascular risk factors
Creators: name: Sandhu, Manavjit
Publisher: name: European Society of Thoracic Imaging
Year: 2014
Subjects: subject: Calcifications / Calculi
subject: Arteriosclerosis
subject: Computer Applications-3D
subject: Comparative studies
subject: Mammography
subject: CT
subject: Cardiovascular system
subject: Cardiac
subject: Breast

description: Purpose Materials and Methods Results Conclusions References Personal Information
description: Purpose: Atherosclerosis leading to cardiovascular diseases is a major cause of mortality and premature morbidity in the world. In the coming future its role will be increased significantly as compared to other causes of mortality. Our aim, therefore was to...
UN LASCIAPASSARE PER L’ITALIA.  LA LEGGE MARONI E L’OBBLIGO DEL TEST DI ITALIANO PER STRANIERI
Creators: name: Sergio, Giuseppe
Publisher: name: Italiano LinguaDue
Year: 2011

description: Per legge, dalla fine del 2010, gli stranieri già residenti nel nostro Paese e intenzionati a richiedere il “permesso CE per soggiornanti di lungo periodo” devono dimostrare di possedere un livello minimo di conoscenza dell’italiano. L’articolo ripercorre il contenuto di questa normativa, soffermandosi sui suoi aspetti operativi e sulle procedure per la somministrazione del test volto all’elicitazione e verifica del profilo di competenza richiesto (corrispondente all’A2 del QCER). Se la legge dimostra di considerare la lingua come irrinunciabile fattore coesivo, allineandosi peraltro a quanto già stabilito in numerosi Paesi europei, diversamente da questi ultimi in Italia il settore formativo versa in condizioni deficitarie. Anche in questa prospettiva critica, l’articolo svolge una rassegna sulla recezione della legge: sostanzialmente positiva da parte dell’opinione pubblica, più circostanziata e criticata da parte dagli addetti ai lavori e, per ragioni diverse, dagli stessi stranieri. Si propone infine un’analisi del test di italiano, così come è stato finora somministrato, cioè sulla base del Vademecum diffuso dal  Miur, ma anche tenendo contrastivamente d’occhio le linee guida precedentemente indicate dagli Enti certificatori.     A pass for Italy. The Maroni law and the obligatory Italian test for foreigners   By law, since 2010, foreign residents in Italy who wish to appy for the “EC long term stay permit” have to demonstrate a minimal knowledge of Italian. The article covers the content of this law, considering the operative aspects and the test procedures aimed at eliciting and verifying the competence profile requested (A2 level of the QCER). Although the law demonstrates that language is a necessary cohesive factor, in line with what other European countries have already established, training in Italy is not up to par with the other countries. In this critival perspective, the article discusses the impact of the law: which has been substantially positive in terms of public opinion, more circumstantial amd criticized by workers and for different reasons, by foreigners. The Italian test is also analyzed, as well as how it has been administered up to now, based on the vademecum made available by Muir, with an eye on the guidelines previously set out by the certification bodies.
description: Italiano LinguaDue, Vol 3, N° 1 (2011)