cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-docx-1-tej-10.1177_20417314231155114 – Supplemental material for A survey to evaluate parameters governing the selection and application of extracellular vesicle isolation methods
Creators: name: Williams, Soraya
name: Jalal, Aveen R
name: Lewis, Mark P
name: Davies, Owen G
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-docx-1-tej-10.1177_20417314231155114 for A survey to evaluate parameters governing the selection and application of extracellular vesicle isolation methods by Soraya Williams, Aveen R Jalal, Mark P Lewis and Owen G Davies in Journal of Tissue Engineering
Fremde in der Nekropole von S. Paolo fuori le mura im Licht der epigraphischen Quellen
Creators: name: Nieddu, Anna Maria
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 98 Nr. 1/2 (2003): Römische Quartalschrift, Band 98, Heft 1/2
sj-docx-1-jtw-10.1177_00472816231161062 - Supplemental material for Emojination Facilitates Inclusive Emoji Design Through Technical Writing: Fitting Tactical Technical Communication Inside Institutional Structures
Creators: name: Gallagher, John R.
name: Avgoustopoulos, Rebecca E.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, sj-docx-1-jtw-10.1177_00472816231161062 for Emojination Facilitates Inclusive Emoji Design Through Technical Writing: Fitting Tactical Technical Communication Inside Institutional Structures by John R. Gallagher and Rebecca E. Avgoustopoulos in Journal of Technical Writing and Communication
Zur heidnisch-christlichen Auseinandersetzung in Rom um die Wende vom 4. zum 5. Jahrhundert
Creators: name: Klein, Richard
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 98 Nr. 1/2 (2003): Römische Quartalschrift, Band 98, Heft 1/2
Additional file 1 of The prognostic value of a combined immune score in tumor and immune cells assessed by immunohistochemistry in triple-negative breast cancer
Creators: name: Choi, Ji Eun
name: Lee, Jae Seok
name: Jin, Min-Sun
name: Nikas, Ilias P.
name: Kim, Kwangsoo
name: Yang, Sunah
name: Park, Soo Young
name: Koh, Jiwon
name: Yang, Sohyeon
name: Im, Seock-Ah
name: Ryu, Han Suk
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Table S1. Expression of the tested immune-related markers in both tumor and immune cells, and its clinicopathological significance.
sj-docx-2-cos-10.1177_00207152231156436 – Supplemental material for Low-wage mobility in Central Europe
Creators: name: Gerbery, Daniel
name: Miklošovič, Tomáš
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-2-cos-10.1177_00207152231156436 for Low-wage mobility in Central Europe by Daniel Gerbery and Tomáš Miklošovič in International Journal of Comparative Sociology
sj-docx-1-pie-10.1177_09544089231159777 - Supplemental material for Experimental investigation on the mechanical performance of the Al2O3 and ZrO2 added Al-Mg-Si alloy for structural applications
Creators: name: Ogunsanya, Olusegun Adebayo
name: Adewale Akinwande, Abayomi
name: Raj Mohan, R
name: Talabi, Henry
name: Saravana Kumar, M
name: Vignesh, M
name: Bhowmik, Abhijit
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-pie-10.1177_09544089231159777 for Experimental investigation on the mechanical performance of the Al2O3 and ZrO2 added Al-Mg-Si alloy for structural applications by Olusegun Adebayo Ogunsanya, Abayomi Adewale Akinwande, R Raj Mohan, Henry Talabi, M Saravana Kumar, M Vignesh and Abhijit Bhowmik in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
sj-docx-1-aut-10.1177_13623613231158959 – Supplemental material for Factors influencing the mental health of autistic children and teenagers: Parents’ observations and experiences
Creators: name: Mukherjee, Suzanne
name: Beresford, Bryony
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-1-aut-10.1177_13623613231158959 for Factors influencing the mental health of autistic children and teenagers: Parents’ observations and experiences by Suzanne Mukherjee and Bryony Beresford in Autism
sj-docx-3-aut-10.1177_13623613231158959 – Supplemental material for Factors influencing the mental health of autistic children and teenagers: Parents’ observations and experiences
Creators: name: Mukherjee, Suzanne
name: Beresford, Bryony
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-3-aut-10.1177_13623613231158959 for Factors influencing the mental health of autistic children and teenagers: Parents’ observations and experiences by Suzanne Mukherjee and Bryony Beresford in Autism
Additional file 3 of MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner
Creators: name: Deng, Shenghe
name: Cheng, Denglong
name: Wang, Jun
name: Gu, Junnan
name: Xue, Yifan
name: Jiang, Zhenxing
name: Qin, Le
name: Mao, Fuwei
name: Cao, Yinghao
name: Cai, Kailin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 3: Figure S1. MYL9 pan-carcinoma analysis. A: Prognostic analysis of MYL9 and tumor. B: The expression level and clinical staging of MYL9 in tumor and normal tissues. C: Correlation analysis between the expression level of MYL9 and the TMB and MSI of tumors. D: Analysis of differences between MYL9 expression and tumor immunoinhibitor, immunostimulator and MHC molecule. E: Analysis of MYL9 expression and tumor drug sensitivity. TMB, tumor mutation burden; MSI, microsatellite instability; MHC, major histocompatibility complex.
Nordafrikanische Märtyrer in der frühen römischen Heiligenverehrung
Creators: name: Baumeister, Theofried
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 98 Nr. 1/2 (2003): Römische Quartalschrift, Band 98, Heft 1/2
Additional file 5 of MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner
Creators: name: Deng, Shenghe
name: Cheng, Denglong
name: Wang, Jun
name: Gu, Junnan
name: Xue, Yifan
name: Jiang, Zhenxing
name: Qin, Le
name: Mao, Fuwei
name: Cao, Yinghao
name: Cai, Kailin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 5: Figure S3. High expression of MYL9 was associated with M2 macrophage infiltration. A: Correlation of MYL9 with stromalScore and immuneScore in colon cancer (COAD) and CRC (READ). B-D: Analysis of the difference and correlation between MYL9 expression and CRC immune cell infiltration in three CRC transcriptome cohorts, B: TCGA cohort, C: GEO cohort, B: Validation cohort from our own transcriptome data. E: Immunohistochemistry indicated that the positive rate of M2 macrophages in the region with high MYL9 expression was significantly higher than that of M0 and M1 macrophages (Scale Bar = 500μm and 50μm). CRC, colorectal cancer.
UrbanHistory4D - e22_XynSJ4qMYi_saalstr_1
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building.The following files are available:Models: saalstr_1.glb | saalstr_1.obj | saalstr_1_ne.glbMetadata: e22_XynSJ4qMYi_saalstr_1.jsonThumbnails: saalstr_1_perspective_1.png | saalstr_1_perspective_2.png | saalstr_1_perspective_3.png | saalstr_1_perspective_4.pngEDM-XMLs: e22_XynSJ4qMYi_saalstr_1_edm.xmlMets/Mods-XMLs: e22_XynSJ4qMYi_saalstr_1_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Fremde in der Bevölkerung des kaiserzeitlichen Rom
Creators: name: Dresken-Weiland, Jutta
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 98 Nr. 1/2 (2003): Römische Quartalschrift, Band 98, Heft 1/2
Additional file 6 of MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner
Creators: name: Deng, Shenghe
name: Cheng, Denglong
name: Wang, Jun
name: Gu, Junnan
name: Xue, Yifan
name: Jiang, Zhenxing
name: Qin, Le
name: Mao, Fuwei
name: Cao, Yinghao
name: Cai, Kailin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 6: Figure S4. CCL2 combined with TGF-β1 promoted the proliferation, migration, and invasion of CRC cells. A: qRT-PCR was used to verify the cytokine changes after MYL9 silencing. B-C: CCK-8 assay showed CCL2 and TGF-β1 promoted the proliferation of LoVo (B) and SW480 (C) cells. D: Transwell assays showed CCL2 and TGF-β1 promoted the migration and invasion of LoVo and SW480 cells (Scale Bar = 100μm). E: A mouse model of subcutaneous tumor. Each bar represents the mean ± SD of the three independent experiments. CRC, colorectal cancer; qRT-PCR, quantitative real-time polymerase chain reaction; CCK-8, cell counting kit-8; SD, standard deviation.
title: Gründervision
title: Arbeitshilfe zur Definition der Gründervision
titleType: Subtitle
Creators: name: Goers, Jana
name: Horton, Graham
name: Kaemmerer, Nance
name: Knoll, Stefan Werner
Publisher: name: Otto von Guericke University Library, Magdeburg, Germany
Year: 2017
Subjects: Founders Playbook
Founders Vision
Gründervision
Arbeitshilfe

description: Diese Arbeitshilfe richtet sich an Gründungsinteressierte in der Anfangsphase, die auf der Suche nach einer Vision für sich und das zukünftige Unternehmen sind. Das Ergebnis dieser Arbeitshilfe ist eine erste Beschreibung der Gründervision, die den Gründern als Motivation und Orientierung dienen kann. Die Arbeitshilfe baut auf dem Kapitel 2.4 Founders Vsion des Founder‘s Playbook (www.founders-playbook.de) auf.
UrbanHistory4D - e22_8En7jXLpdC_johannis_friedhof_1
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building.The following files are available:Models: johannis_friedhof_1.glb | johannis_friedhof_1.obj | johannis_friedhof_1_ne.glbMetadata: e22_8En7jXLpdC_johannis_friedhof_1.jsonThumbnails: johannis_friedhof_1_perspective_1.png | johannis_friedhof_1_perspective_2.png | johannis_friedhof_1_perspective_3.png | johannis_friedhof_1_perspective_4.pngEDM-XMLs: e22_8En7jXLpdC_johannis_friedhof_1_edm.xmlMets/Mods-XMLs: e22_8En7jXLpdC_johannis_friedhof_1_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Employing comparative QSAR techniques for the recognition of dibenzofuran and dibenzothiophene derivatives toward MMP-12 inhibition
Creators: name: Tamang, Jigme Sangay Dorjay
name: Banerjee, Suvankar
name: Baidya, Sandip Kumar
name: Ghosh, Balaram
name: Adhikari, Nilanjan
name: Jha, Tarun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Among various matrix metalloproteinases (MMPs), MMP-12 is one of the potential targets for cancer and other diseases. However, none of the MMP-12 inhibitors has passed the clinical trials to date. Therefore, designing potential MMP-12 inhibitors as new drug molecules can provide effective therapeutic strategies for several diseases. In this study, a series of dibenzofuran and dibenzothiophene derivatives were subjected to different 2D and 3D-QSAR techniques to point out the crucial structural contributions highly influential toward the MMP-12 inhibitory activity. These techniques identified some structural attributes of these compounds that are responsible for influencing their MMP-12 inhibition. The carboxylic group may enhance proper binding with catalytic Zn2+ ion at the MMP-12 active site. Again, the i-propyl sulfonamido carboxylic acid function contributed positively toward MMP-12 inhibition. Moreover, the dibenzofuran moiety conferred stable binding at the S1′ pocket for higher MMP-12 inhibition. The steric and hydrophobic groups were found favourable near the furan ring substituted at the dibenzofuran moiety. Besides these ligand-based approaches, molecular docking and molecular dynamic (MD) simulation studies not only elucidated the importance of several aspects of these MMP-12 inhibitors while disclosing the significance of the finding of these QSAR studies and their influences toward MMP-12 inhibition. The MD simulation study also revealed stable and compact binding between such compounds at the MMP-12 active site. Therefore, the findings of these validated ligand-based and structure-based molecular modeling studies can aid the development of selective and potent lead molecules that can be used for the treatment of MMP-12-associated diseases. Communicated by Ramaswamy H. Sarma
Exploring the chemical space for potential inhibitors against cell surface binding protein of Mpox virus using molecular fingerprint based screening approach
Creators: name: Chaudhuri, Dwaipayan
name: Majumder, Satyabrata
name: Datta, Joyeeta
name: Giri, Kalyan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Mpox virus is the latest member of the Poxviridae family of which small pox virus is a member. Monekypox virus has led to thousands of infections across the globe. Poxvirus gains entry into the cell making use of glycosaminoglycans like chondroitin sulphate and heparan sulphate. The interaction of the Mpox virus protein E8L also called cell surface binding protein is crucial for host cell attachment, membrane fusion and viral entry into the host cell leading to establishment of infection thus making this protein a very attractive therapeutic target. In this study we have tried to utilize the chondroitin sulphate binding groove present in the protein and identify molecules which are structurally similar to chondroitin sulphate. These molecules can thus occupy the same pocket but with a better binding affinity than chondroitin sulphate in order to outcompete the latter molecule from binding to the E8L protein and thus prevent it from performing its function. This study may pave the way for development of highly efficient therapeutics against the Mpox virus and further curb its infective potential. Communicated by Ramaswamy H. Sarma
[Rezension von: Sörries, Reiner, Josef Wilpert, (1857 - 1944), ein Leben im Dienste der christlichen Archäologie]
Creators: name: Gatz, Erwin
name: Sörries, Reiner
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
[Rezension von: Römische Katakombenmalereien im Spiegel des Photoarchivs Parker, Dokumentation von Zustand und Erhaltung, 1864 - 1994, Klaus-Dieter Dorsch; Hans Reinhard Seeliger. Mit einem einf. Beitr. von Fabrizio Bisconti]
Creators: name: Heid, Stefan
name: Seeliger, Hans Reinhard
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
In silico screening-based discovery of benzamide derivatives as inhibitors of Rho-associated kinase-1 (ROCK1)
Creators: name: Xu, Qi-Xuan
name: Guo, Liang
name: Li, Yuan
name: Wang, Zhao-Wei
name: Hu, Po
name: Yang, Guang-Ming
name: Pan, Yang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: As a pivotal node in modulating various cell behaviors, Rho-associated kinase-1 (ROCK1) has attracted significant attention as a promising therapeutic target in a variety of diseases. Benzamide has been widely reported as a ROCK1 inhibitors in recent years. To better understand its pharmacological properties and to explore its potential inhibitors, a series of ROCK1 inhibitors derived from N-methyl-4-(4-pyrazolidinyl) benzamides (MPBs) were investigated by using three-dimensional quantitative structure-activity relationship (3D-QSAR) models, pharmacophore models, molecular docking, and molecular dynamics (MD) simulation. The comparative Molecular Field Analysis (CoMFA) model (q2 = 0.616, R2 = 0.972, ONC = 4, and r2pred = 0.983) and the best Comparative Molecular Similarity Indices Analysis (CoMSIA) model (q2= 0.740, R2 = 0.982, ONC = 6, and r2pred = 0.824) exhibited reliable predictability with satisfactory validation parameters. In the subsequent virtual screening, VS03 and VS05 were identified to have superior predicted activities and higher docking scores, meanwhile they demonstrated to be reasonably stable in the binding pocket through MD simulations. These results provide a significant theoretical direction for the rational design and development of novel ROCK1 inhibitors. Communicated by Ramaswamy H. Sarma
54669: A woman war worker activating the filter press in a Lancashire glucose factory
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: No description available.
[Rezension von: Groblewski, Michael, Thron und Altar, der Wiederaufbau der Basilika St. Paul vor den Mauern (1823 - 1854)]
Creators: name: Gatz, Erwin
name: Groblewski, Michael
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
Supplemental Material - Randomized Controlled Trial Aversion among Public Sector Leadership: A Survey Experiment
Creators: name: Cardon, Emily
name: Lopoo, Leonard
Publisher: name: SAGE Journals
Year: 2023
Subjects: Sociological Methodology and Research Methods

description: Supplemental Material for Randomized Controlled Trial Aversion among Public Sector Leadership: A Survey Experiment by Emily Cardon, and Leonard Lopoo in Evaluation Review
[Rezension von: Tewes, Götz-Rüdiger, Die römische Kurie und die europäischen Länder am Vorabend der Reformation]
Creators: name: Gatz, Erwin
name: Tewes, Götz-Rüdiger
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
[Rezension von: Geschichte des christlichen Lebens im schlesischen Raum, Joachim Köhler; Rainer Bendel (Hrsg.)]
Creators: name: Gatz, Erwin
name: Köhler, Joachim
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
Additional file 1 of The ongoing risk of Leishmania donovani transmission in eastern Nepal: an entomological investigation during the elimination era
Creators: name: Roy, Lalita
name: Cloots, Kristien
name: Uranw, Surendra
name: Rai, Keshav
name: Bhattarai, Narayan R.
name: Smekens, Tom
name: Hendrickx, Rik
name: Caljon, Guy
name: Hasker, Epco
name: Das, Murari L.
name: Van Bortel, Wim
Publisher: name: figshare
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Table S1. The cumulative caseload in VL endemic and non-endemic districts in the past 3 years, 2014–16, prior to the inception of the sand fly collection.
Caso clínico: malrotación intestinal con vólvulo intestinal
Creators: name: Sanmartín Bermeo, Magaly Mishelle
name: Ortega Larrea, Daniel Esteban
name: Engel Arrieta, Karla Patricia
Publisher: name: Zenodo-HGOIA
Year: 2024
Subjects: subject: neonatology
subject: pediatrics
subject: Surgery

description: Las Malrotaciones Intestinales son un conjunto de anomalías congénitas durante la embriogénesis del intestino, las que pueden conllevar a complicaciones en el periodo Neonatal y la Infancia, entre la cuales se destaca la obstrucción intestinal, vólvulo Intestinal, intususcepción, entre otras (1). A nivel Global afecta a 1/500 neonatos, predominando en hombres. Es una emergencia quirúrgica potencialmente fatal. Es causada por alteraciones en la fijación del duodeno y colon durante el desarrollo embrionario, generando un mesenterio estrecho con alto riesgo de vólvulo intestinal. La rotación y fijación del intestino medio, que ocurre entre la 5ª y 10ª semana de gestación, puede interrumpirse, originando síntomas como vómito bilioso, distensión abdominal y dolor. Complicaciones como vólvulo (vómito bilioso, heces sanguinolentas) o intususcepción (invaginación intestinal, "signo de dona" en ecografía) requieren intervención quirúrgica inmediata para evitar desenlaces fatales.
Halogen substituted aurones as potential apoptotic agents: synthesis, anticancer evaluation, molecular docking, ADMET and DFT study
Creators: name: Nabi, Syed Ayaz
name: Ramzan, Farhat
name: Lone, Mehak Saba
name: Nainwal, Lalit Mohan
name: Hamid, Aabid
name: Batool, Faiqah
name: Husain, Mohammad
name: Samim, Mohammed
name: Shafi, Syed
name: Sharma, Kalicharan
name: Bano, Sameena
name: Javed, Kalim
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Cell Biology
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology
Virology

description: A series of halogen-substituted aurone derivatives (2a-k) were synthesized and evaluated for an anti-proliferative study against NCI 60 cancer cell line panel and showed that most of the compounds predominantly exhibited promising activity against MCF-7. Compound 2e exhibited promising anticancer activity against the MCF-7 cancer cell line with 84.98% percentage growth inhibition in a single dose assay of 10 μM with an IC50 value of 8.157 ± 0.713 μM. In apoptotic assay, the effect of compound 2e on the cell cycle progression indicated that exposure of MCF-7 cells to compound 2e induced a significant disruption in the cell cycle profile including a time-dependent decrease in the cell population at G0/G1 and G2/M phase and arrests the cell cycle at the S phase. In silico, molecular docking ADME and toxicity studies of all compounds were also carried out. The docking study revealed that all the aurone derivatives displayed good docking scores ranging from −7.066 to −8.573. The results of Molecular Electrostatic Potential Mapping (MESP) and Density Functional Theory (DFT) studies of the most active compound 2e and least active compound 2k also favoured the experimental results. Communicated by Ramaswamy H. Sarma
[Rezension von: Wallraff, Martin, Christus verus sol, Sonnenverehrung und Christentum in der Spätantike]
Creators: name: Heid, Stefan
name: Wallraff, Martin
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
55601: Pozieres Memorial and Cemetery
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Graves and central aisle.
Design, synthesis, evaluation of biological activities and molecular docking and dynamic studies of novel acetazolamide analog compounds
Creators: name: Osmaniye, Derya
name: Yuva, Onur
name: Sağlık, Begüm Nurpelin
name: Levent, Serkan
name: Ozkay, Yusuf
name: Kaplancıklı, Zafer Asım
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Modification of drugs used in the clinic is a frequently used method with regards to medicinal chemistry in the development of new drugs. Acetazolamide is a drug in clinical use as a CA inhibitor. Within the scope of this study, the 'N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl) acetamide’ structure, which is acetazolamide residue, was kept constant; various mercaptan substitutions were made from methylene adjacent to the carbonyl group in the structure. Compounds 4c, 4d, 4e, 4 g, 4h, 4i, and 4j exhibited inhibitor activity against CA enzyme with IC50=0.238 ± 0.010, 0.161 ± 0.007, 0.067 ± 0.002, 0.084 ± 0.003, 0.033 ± 0.001, 0.049 ± 0.002 and 0.187 ± 0.008 µM, respectively. The intermolecular interactions of the promising compounds with aromatase enzyme were investigated through the SP docking approach, which revealed significant binding interaction energies associated with these compounds. To measure the stability of the compounds in the enzyme active site, dynamic studies were performed at 100 ns. In addition to the RMSD, RMSF parameters, the interaction ratios of compound 4h with amino acids in the enzyme active site and the interaction histograms were also investigated. The results obtained are quite promising. Continuous interactions were exhibited with Thr199, Glu106, His96, His94 and His119, which are important for the CA enzyme. Communicated by Ramaswamy H. Sarma
[Rezension von: La geografia della Città di Roma e lo spazio del sacro, l'esempio delle trasformazioni territoriali lungo il percorso della visita alle sette chiese privilegiate, contr. di Barbara Falco ... Coord. a cura di Claudio Cerreti]
Creators: name: Heid, Stefan
name: Falco, Barbara
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
Supplemental Material - Acrylamide-induced meiotic arrest of spermatocytes in adolescent mice by triggering excessive DNA strand breaks: Potential therapeutic effects of resveratrol
Creators: name: Gao, Y
name: Zhang, D
name: Wang, P
name: Qu, X
name: Xu, J
name: Yu, Y
name: Zhou, X
Publisher: name: SAGE Journals
Year: 2023
Subjects: Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental Material for Acrylamide-induced meiotic arrest of spermatocytes in adolescent mice by triggering excessive DNA strand breaks: Potential therapeutic effects of resveratrol by Y Gao, D Zhang, P Wang, X Qu, J Xu, Y Yu and X Zhou in Human & Experimental Toxicology.
[Rezension von: Spätantike Zentralbauten in Rom und Latium, Bd. 3, Das Mausoleum der Kaiserin Helena in Rom und der "Tempio della Tosse" in Tivoli, Institut für Baugeschichte der Universität Karlsruhe und Deutsches Archäologisches Institut. Begr. von Arnold Tschira ... Hrsg. in Verbindung mit Friedrich Wilhelm Deichmann von Wulf Schirmer]
Creators: name: Dresken-Weiland, Jutta
name: Rasch, Jürgen J.
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
UrbanHistory4D - e22_VUxZV7zn2_fuerstengraben_30
Creators: name: Digital Humanities Jena
Publisher: name: Zenodo
Year: 2024

description: This Record contains files related to the building models that were created by the Project UrbanHistory4D, specifically referring to this building.The following files are available:Models: fuerstengraben_30.glb | fuerstengraben_30.obj | fuerstengraben_30_ne.glbMetadata: e22_VUxZV7zn2_fuerstengraben_30.jsonThumbnails: fuerstengraben_30_perspective_1.png | fuerstengraben_30_perspective_2.png | fuerstengraben_30_perspective_3.png | fuerstengraben_30_perspective_4.pngEDM-XMLs: e22_VUxZV7zn2_fuerstengraben_30_edm.xmlMets/Mods-XMLs: e22_VUxZV7zn2_fuerstengraben_30_metsmods.xmlThese are the suffix-codes for the model files:_lr = Low Resolution. Converted 3D model including textures with a maximum resolution of 512px. Null, if there aren't any textures._ne = No Edges. Converted 3D model without generated edges._nelr = No Edges + Low Resolution. Converted 3D model without edges including textures with a maximum resolution of 512px. Null, if there aren't any textures.Please refer to the UH4D API Documentation for further Information.
Zum Stand der Diözesangeschichtsschreibung im deutschsprachigen Mitteleuropa
Creators: name: Gatz, Erwin
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
Structural and dynamic properties of urinary human serum albumin fragments: a molecular dynamics study
Creators: name: Archapraditkul, Chanya
name: Janon, Kanokwan
name: Japrung, Deanpen
name: Pongprayoon, Prapasiri
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Computational Biology

description: A microalbuminuria level acts as a good index to screen and monitor diabetes and renal failure. However, the urinary albumin loss after sample preservation and storage is the major bottleneck to obtain the accurate microalbuminuria test. Such loss is due to the rapid albumin fragmentation by urinary proteases. Some fragments were suggested to be bioactive biomarkers of diabetes and renal disease, but no structural and dynamical properties of albumin fragments are available. Thus, in this work, the structural and dynamical properties of reported albumin fragments are revealed using molecular dynamics simulations. The properties of nine fragments (F1–F9) discovered recently were studied at the real pH conditions of urine samples (pH 4.5, 7 and 8). The complete loss of secondary structure is found in short fragments (F1–F6), while large-sized polypeptides (F7–F9) can somehow maintain their folds. Especially, F8 (subdomain IIIB) is the most stable fragment. The difference in histidine protonation states has no impact on the structural stability of albumin fragments. The ability of F8 (subdomain IIIB) to maintain its stability and folds suggests it as an alternative albumin biomarker in urine. An insight obtained here will become the fundamental importance for understanding clinical assays for albumin detection, sample stability and peptidomics analysis of urine. Communicated by Ramaswamy H. Sarma
title: Begrenzing van het marien gebied: drie studiegebieden in Vlaanderen
Creators: name: De Buyser, Silke
name: Devriese, Lisa
name: Lonneville, Britt
name: Verleye, Thomas
Publisher: name: Flanders Marine Institute
Year: 2024

description: Title :
Volume :
Issue :
Pagination : 26
Worldwide evidence of a unimodal relationship between productivity and plant species richness
Creators: name: Fraser, Lauchlan H.
name: Pither, Jason
name: Jentsch, Anke
name: Sternberg, Marcelo
name: Zobel, Martin
name: Askarizadeh, Diana
name: Bartha, Sandor
name: Beierkuhnlein, Carl
name: Bennett, Jonathan A.
name: Bittel, Alex
name: Boldgiv, Bazartseren
name: Boldrini, Ilsi I.
name: Bork, Edward
name: Brown, Leslie
name: Cabido, Marcelo
name: Cahill, James
name: Carlyle, Cameron N.
name: Campetella, Giandiego
name: Chelli, Stefano
name: Cohen, Ofer
name: Csergo, Anna-Maria
name: Diaz, Sandra
name: Enrico, Lucas
name: Ensing, David
name: Fidelis, Alessandra
name: Fridley, Jason D.
name: Foster, Bryan
name: Garris, Heath
name: Goheen, Jacob R.
name: Henry, Hugh A. L.
name: Hohn, Maria
name: Jouri, Mohammad Hassan
name: Klironomos, John
name: Koorem, Kadri
name: Lawrence-Lodge, Rachael
name: Long, Ruijun
name: Manning, Peter
name: Mitchell, Randall
name: Moora, Mari
name: Muller, Sandra C.
name: Nabinger, Carlos
name: Naseri, Kamal
name: Overbeck, Gerhard E.
name: Palmer, Todd M.
name: Parsons, Sheena
name: Pesek, Mari
name: Pillar, Valerio D.
name: Pringle, Robert M.
name: Roccaforte, Kathy
name: Schmidt, Amanda
name: Shang, Zhanhuan
name: Stahlmann, Reinhold
name: Stotz, Gisela C.
name: Sugiyama, Shu-ichi
name: Szentes, Szilard
name: Thompson, Don
name: Tungalag, Radnaakhand
name: Undrakhbold, Sainbileg
name: van Rooyen, Margaretha
name: Wellstein, Camilla
name: Wilson, J. Bastow
name: Zupo, Talita
name: Díaz, Sandra
name: Manning, Pete
name: Müller, Sandra C.
name: Pillar, Valério D.
name: Szentes, Szilárd
Publisher: name: Zenodo
Year: 2021
Subjects: productivity-diversity relationship
coordinated distributed experiment
Humped-back model

description: The search for predictions of species diversity across environmental gradients has challenged ecologists for decades. The humped-back model (HBM) suggests that plant diversity peaks at intermediate productivity; at low productivity few species can tolerate the environmental stresses, and at high productivity a few highly competitive species dominate. Over time the HBM has become increasingly controversial, and recent studies claim to have refuted it. Here, by using data from coordinated surveys conducted throughout grasslands worldwide and comprising a wide range of site productivities, we provide evidence in support of the HBM pattern at both global and regional extents. The relationships described here provide a foundation for further research into the local, landscape, and historical factors that maintain biodiversity.
description: raw plot data from globally distributed sitesfraser_plotdata.csv
R script for within_site_GLMs_Fig2A_TableS2within_site_GLMs_Fig2A_TableS2.R
R script for Table_1_analyses_FigS1Table_1_analyses_FigS1.R
R script for varied_grain_analyses_FigS2varied_grain_analyses_FigS2.R
R script for HBmodels_FigS3HBmodels_FigS3.R
R script for max_richness_FigS4max_richness_FigS4.R
R script for within_site_GLMs_reduced_data_Figs_S5_2B_S6within_site_GLMs_reduced_data_Figs_S5_2B_S6.R
Structure-based drug designing against Leishmania donovani using docking and molecular dynamics simulation studies: exploring glutathione synthetase as a drug target
Creators: name: Sarma, Manash
name: Borkotoky, Subhomoi
name: Dubey, Vikash Kumar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: In the pursuit of developing novel anti-leishmanial agents, we conducted an extensive computational study to screen inhibitors from the FDA-approved ZINC database against Leishmania donovani glutathione synthetase. The three-dimensional structure of Leishmania donovani glutathione synthetase was constructed by homology modeling, using the crystallographic structure of Trypanosoma brucei glutathione synthetase as a template. Subsequently, molecular docking studies were carried out for a large number of compounds using AutoDock Vina. Among the screened compounds, we selected the top five with strong binding affinity to Leishmania donovani glutathione synthetase but having a very low affinity to its human homolog. Further investigations on protein-ligand complexes were done by conducting molecular dynamics (MD) simulation and MM/PBSA analysis. The results revealed that Olysio (Simeprevir) exhibited the lowest binding energy (-89.21 kcal/mol), followed by Telithromycin (-45.34 kcal/mol). These findings showed that these compounds have the potential to act as inhibitors of glutathione synthetase. Hence, our study provides valuable insights for the development of a novel therapeutic strategy against Leishmania donovani by targeting the glutathione synthetase enzyme. Communicated by Ramaswamy H. Sarma
sj-pdf-1-imr-10.1177_03000605231184046 - Supplemental material for Association with controlling nutritional status score and disease activity of ulcerative colitis
Creators: name: Lian, Ziyu
name: Hu, Jingyi
name: Cheng, Cheng
name: Liu, Yajun
name: Zhu, Lei
name: Shen, Hong
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605231184046 for Association with controlling nutritional status score and disease activity of ulcerative colitis by Ziyu Lian, Jingyi Hu, Cheng Cheng, Yajun Liu, Lei Zhu and Hong Shen in Journal of International Medical Research
Bischofsamt und Hofdienst in der Kirchenprovinz Salzburg am Ausgang des Mittelalters
Creators: name: Schmid, Alois
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 97 Nr. 3/4 (2002): Römische Quartalschrift, Band 97, Heft 3/4
51049: Trench life and guard duty. Difficulties of sleeping.
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: British private served with Hampshire Regt in GB, 1917-1918; served with Worcestershire Regt on Western Front, 1917-1918
ATTITUDE ESTIMATION USING LIGHT CURVES
Creators: name: Burton, Alexander
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 400199
subject: Aerospace engineering not elsewhere classified
classificationCode: 510901
subject: Astrodynamics and space situational awareness

description: Tracking and characterizing the space debris population in Earth orbit is necessary to ensure that space can continue to be used safely. However, because space objects are affected by non-conservative forces like drag and solar radiation pressure, predicting the long-term evolution of their orbits is impossible without knowledge of their attitude profiles. Such knowledge may be unavailable for inactive satellites or objects of which the observer is not the owner or operator. In many cases, attitude cannot be measured directly because resolved images of space objects are unavailable due to the distance between the object and the observer, and the effects of atmospheric seeing. However, the total brightness of objects can still be measured. A set of brightness measurements over time is referred to as a "light curve.'' An object's observed brightness is influenced by its attitude and other factors such as its orbit, shape, and reflective properties. If some of these other factors are known, attitude information may be extracted from a light curve. Existing methods of solving this attitude inversion problem either require a good initial guess for an object's rotational states or do not provide a full state estimate. The work in this thesis avoids both problems and provides a full state estimate without requiring an initial state guess.
The attitude estimation process assumes that the observation geometry and the observed object's shape, reflection properties, and inertia tensor are known. In this thesis, an initial method of searching for attitudes that could correspond to each measurement using the viewing sphere is described. These possible attitudes or "pseudo-measurements'' are then used to initialize a probability hypothesis density filter that is theoretically capable of representing the multi-modal nature of the attitude estimate using a Gaussian mixture model. However, the probability hypothesis density filter is found to often diverge from the truth because it is necessary to merge and prune components of the Gaussian mixture model to avoid computational intractability. In its place, a particle swarm optimizer method for performing an attitude inversion has been developed. This method uses analytic attitude solutions to quickly propagate a large number of attitude time histories simultaneously. The particle swarm optimizer method is validated using simulated light curves for several objects. A preliminary attempt is made to estimate the attitude of an object using real light curve measurements.
51308: Tanks and barbed wire
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Mark 1 'Female' tank crossing a low barbed wire entaglement. Tank is numbered 'A17' and named 'Oh I Say!'. A staged photograph showing the ability of tanks to cross barbed wire.
Discovery of novel and highly potential inhibitors of glycogen synthase kinase 3-beta (GSK-3β) through structure-based pharmacophore modeling, virtual computational screening, docking and in silico ADMET analysis
Creators: name: Benghanem, Soumia
name: Mesli, Fouzia
name: Zohra, Hadjadj Aoul Fatima
name: Nacereddine, Chaida
name: Hadjer, Chenaffa
name: Abdellatif, Merzoug
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: The protein Glycogen Synthase Kinase 3-Beta (GSK-3β), is a promising therapeutic target for treating various diseases such as neurodegenerative disorders, diabetes, inflammation and cancer. This study aims to investigate the potential of compounds targeting inflammation or carbohydrate metabolism to selectively inhibit GSK3β by binding to its ATP site. To achieve this goal, we filtered a database of 49367 molecules involved in carbohydrate metabolism or targeting inflammation using various computational analyses, including pharmacophore modeling, molecular docking, dynamic simulation, prime MM-GBSA calculation, and in silico ADME studies. We generated a pharmacophore model (hypo S: AADDHRR) using two different crystallographic complexes of GSK3β and evaluated the model’s performance in identifying hits using various parameters, including EF, GH, ROC, AUC and BEDROC. Subsequently, we performed various dockings (HTVS, SP, XP and IFD) for the retrieved hits and found that, 5 out of the top 10 ranked compounds had the scaffold of pyrazolidine 3,5-dione, which has never been reported to inhibit kinases. We also conducted ADMET studies to and concluded that compound N6 exhibited the best pharmacokinetic profile passing the blood-brain barrier, possessing high lipophilicity and a high coefficient of skin permeability in the intestines, along with good bioavailability and low toxicity risk assessment. Dynamic simulation were also performed indicating that compounds N6 derived from pyrazolidine 3,5-dione demonstrated better binding potential for GSK3β during the simulation period. Therefore, we propose that compounds derived from pyrazolidine-3,5-dione, which modulate the activity of lysosomal alpha-glucosidase could serve as a novel scaffold for the selective inhibition of GSK-3β. Communicated by Ramaswamy H. Sarma