Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Creators: name: Papadimitriou, Nikos
name: Dimou, Niki
name: Tsilidis, Konstantinos K.
name: Banbury, Barbara
name: Martin, Richard M.
name: Lewis, Sarah J.
name: Kazmi, Nabila
name: Robinson, Timothy M.
name: Albanes, Demetrius
name: Aleksandrova, Krasimira
name: Berndt, Sonja I.
name: Timothy Bishop, D.
name: Brenner, Hermann
name: Buchanan, Daniel D.
name: Bueno-De-Mesquita, Bas
name: Campbell, Peter T.
name: Castellví-Bel, Sergi
name: Chan, Andrew T.
name: Chang-Claude, Jenny
name: Ellingjord-Dale, Merete
name: Figueiredo, Jane C.
name: Gallinger, Steven J.
name: Giles, Graham G.
name: Giovannucci, Edward
name: Gruber, Stephen B.
name: Gsur, Andrea
name: Hampe, Jochen
name: Hampel, Heather
name: Harlid, Sophia
name: Harrison, Tabitha A.
name: Hoffmeister, Michael
name: Hopper, John L.
name: Hsu, Li
name: María Huerta, José
name: Huyghe, Jeroen R.
name: Jenkins, Mark A.
name: Keku, Temitope O.
name: Kühn, Tilman
name: La Vecchia, Carlo
name: Le Marchand, Loic
name: Li, Christopher I.
name: Li, Li
name: Lindblom, Annika
name: Lindor, Noralane M.
name: Lynch, Brigid
name: Markowitz, Sanford D.
name: Masala, Giovanna
name: May, Anne M.
name: Milne, Roger
name: Monninkhof, Evelyn
name: Moreno, Lorena
name: Moreno, Victor
name: Newcomb, Polly A.
name: Offit, Kenneth
name: Perduca, Vittorio
name: Pharoah, Paul D. P.
name: Platz, Elizabeth A.
name: Potter, John D.
name: Rennert, Gad
name: Riboli, Elio
name: Sánchez, Maria-Jose
name: Schmit, Stephanie L.
name: Schoen, Robert E.
name: Severi, Gianluca
name: Sieri, Sabina
name: Slattery, Martha L.
name: Song, Mingyang
name: Tangen, Catherine M.
name: Thibodeau, Stephen N.
name: Travis, Ruth C.
name: Trichopoulou, Antonia
name: Ulrich, Cornelia M.
name: Van Duijnhoven, Franzel J. B.
name: Van Guelpen, Bethany
name: Vodicka, Pavel
name: White, Emily
name: Wolk, Alicja
name: Woods, Michael O.
name: Wu, Anna H.
name: Peters, Ulrike
name: Gunter, Marc J.
name: Murphy, Neil
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/67
/631/67/1347
/631/67/2324
/631/67/68
/631/67/1504/1885
/45
/45/23
/141
article

description: Abstract: Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.