Metadata supporting the published article: Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: results from a prospective cohort study
Creators: name: Wang, Kang
name: Sun, Jiazheng
name: Wu, Qianxue
name: Li, Zhuyue
name: Li, Daxue
name: Xiong, Yongfu
name: Zhong, Guochao
name: Shi, Yang
name: Li, Qing
name: Zheng, Jiali
name: Shivappa, Nitin
name: Hébert, James R.
name: Foukakis, Theodoros
name: Zhang, Xiang
name: Li, Hongyuan
name: Xiang, Tingxiu
name: Ren, Guosheng
Publisher: name: figshare
Year: 2020
Subjects: Cancer
Nutrition and Dietetics not elsewhere classified

description: This metadata record summarises the scope, availability and access conditions for data supporting the article <i>Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: results from a prospective cohort study</i>.<br>The study investigates the association between post-diagnosis dietary inflammatory index (DII®) and risks of all-cause and breast cancer-specific mortality. Data are derived from a cohort of 1064 breast cancer survivors, who had completed a diet history questionnaire (DHQ) after breast cancer diagnosis.<br>All data are available from the NIH Cancer Data Access System for the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: https://cdas.cancer.gov/plco/<br><b>Data access conditions: </b><br>To access data, prospective users must: Register at https://cdas.cancer.gov/learn/plco/instructions/Submit a project proposalAgree to data use policies - including protecting identities of patients and physicians within dataProvide a name and description of their projectList all users approved to access dataComplete and data transfer agreement (including deidentification - some of which is already carried out on available data)Proposals are reviewed by CDAS staff - in terms of whether sensitive data are necessary for project. Then by National Cancer Institute (NCI) - which addresses whether your project addresses a scientific question and whether this is appropriate for the data. There is no assessment for scientific merit or uniqueness.<br><b>Sample size</b><b><br></b>A cohort of 1064 breast cancer survivors who had completed the DHQ were reported in the related article. These are part of a wider trial cohort of 78,000 whose data are available via the CDAS link above.<br><b>Background and data</b><br><b><br></b>The study addresses the impact of diet on breast-cancer related mortality, specifically in terms of chronic inflammation implicated in breast cancer and nutrients that modulate inflammation.<br>PLCO was conducted in the United States to determine the effects of screening on cancer-related mortality and secondary endpoints. In total, 154,897 eligible participants (76,682 males and 78,215 females), aged 55-74 years were enrolled from November 1993 to July 2001. Participants were individually randomized to intervention or control groups in equal proportions. Data were collected on 17 cancer diagnoses and deaths from all causes that occurred through July 31, 2011.<br>In the DHQ, participants reported their frequency of intake and portion size of 124 food items and supplement use over the previous year.<br><br>The DII is a literature-derived, population-based index designed to estimate the overall inflammatory potential of an individual’s diet.<br><br>Energy-adjusted DII (E-DII) scores were calculated based on food and supplement intake. This is a composite measure which takes into account inflammatory effects of overall diet of an individual as opposed to looking at specific nutrients or food items.<br><br>Available data include 2 breast cancer-specific datasets in csv/SAS format and baseline questionnaires with 64 questions on individual and family medical history. <br>Data dictionaries and user guides are available from:https://cdas.cancer.gov/datasets/plco/ <br><br>Clinical trial registration numbers: NCT00002540 (Prostate), NCT01696968 (Lung), NCT01696981 (Colorectal), NCT01696994 (Ovarian), and NCT00339495 (EEMS).<br>