cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Exploring the combinatorial effects of inflammatory stimuli and glucocorticoids on BIRC3 and BIRC2 expression: Differential regulation and functional investigations
Creators: name: Thorne, Andrew James
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Inflammation
subject: Glucocorticoids
subject: BIRC3
subject: BIRC2
subject: Airways
subject: NF-kB
subject: Biology--Cell
subject: Biology--Molecular
subject: Genetics
subject: FOS: Biological sciences

description: Inflammation serves as a crucial innate mechanism in response to injury, infection, or harmful stimuli that activates the immune system and aims to restore homeostasis. Chronic inflammatory disorders like asthma present with ongoing inflammation whereby pulmonary epithelial cells release inflammatory mediators, intensifying airway inflammation, and worsening disease. Synthetic glucocorticoids represent the primary treatment for asthma by utilizing the anti-inflammatory properties of their endogenous counterparts to reduce inflammatory mediators. Their mechanism of action involves binding to the glucocorticoid receptor (GR) in cells and interacting with DNA elements to enhance anti-inflammatory gene expression. However, certain inflammatory genes play protective roles by promoting tissue repair or self-regulatory feedback mechanisms to limit inflammatory signaling. Some of these genes are spared the repressive effects of glucocorticoids and are even augmented, presumably for protection. The BIRC3 gene, while being associated with the inflammatory NF-κB pathway, is a gene upregulated in models of the pulmonary epithelium and in vivo by glucocorticoids. BIRC3, along with its family member BIRC2, may contribute to regulating NF-κB pathways, but also inhibit apoptosis, although their specific roles remain unclear. Consequently, the rationale of glucocorticoid-enhanced BIRC3 remain ambiguous. Given their similarities, BIRC3 and BIRC2 were both investigated, focusing on their expression, regulation, and the interactions between the GR and NF-κB at the gene promoter. These analyses detailed robust expression patterns differentiating BIRC3 and BIRC2 by their response to inflammatory cytokines and glucocorticoids over time. Promoter analysis revealed insights into possible GR and NF-κB interactions to explain the regulation of BIRC3 expression, thus providing an example of GR-NF-κB positive interactions leading to inflammatory gene expression. Further, investigations into the NF-κB pathway as a platform for BIRC2/3 function revealed the established canonical NF-κB pathway may challenge established dogma. This exploratory research highlighted the significance of TAK1 as central kinase within the NF-κB pathway. Moreover, possible redundancy between IKK1 and IKK2, and the presence of additional regulators within canonical NF-κB signaling may exist. While this study provided no greater insights for redundant, or individual roles for BIRC2/3 in NF-κB signaling or apoptosis, it facilitated the development of tools for future investigations.
A Novel Scalable Approach to Solid Metal Microneedle Fabrication via an Automated Modified Wire Bonding Process
Creators: name: Haider, Syed Kazim
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Microneedles
subject: Microneedle array
subject: Wire bonding
subject: Ball bonding
subject: Additive fabrication process for microneedle arrays
subject: Microfabrication
subject: bioMEMS
subject: Microarray patch
subject: Solid metal microneedles
subject: Metal microneedles
subject: Engineering--Biomedical
subject: Engineering

description: Hypodermic needles have played a pivotal role in medical treatments; however, their use often incites fear due to pain and tissue trauma. Microneedle arrays present a promising alternative, with their smaller size resulting in reduced pain and trauma, however they have faced manufacturing scale-up challenges due to the complex microfabrication processes involved, precluding their widespread adoption into clinical practice. This research introduces a novel microneedle fabrication method utilizing a modified wire bonding process, enabling rapid iteration of designs on a single automated system. Key fabrication parameters, such as loop settings and wire bonding capillary shape, were explored to understand their impact on microneedle geometry. This study finds how specific wire bonding parameters can influence microneedle tip sharpness, crucial for efficient skin penetration. Additionally, the research delves into how these parameters affect microneedle length, a crucial factor for delivering drugs to a sufficient depth below skin. A significant aspect of this work involved investigating three different bonding wire diameters (25, 33, and 50 µm). The findings revealed that the largest diameter, 50 µm, exhibited optimal performance in terms of robustness, and had the least tendency to bend upon insertion into porcine skin tissue, and the lowest failure rate during microneedle fabrication. Initial tests on porcine skin validated the effective penetration ability of the wire bonded microneedles. A computational simulation was also developed to illustrate how the unique tip shapes, achievable through wire bonding, can enhance skin penetration. This iterative process, encompassing simulation, fabrication, and testing, underscores the potential of this novel fabrication method as a versatile platform technology. This research lays a solid foundation for broad applications, paving the way for future optimizations and adaptations tailored to specific microneedle requirements for different applications.
Thyreocephalus macrophallus Bordoni, 2013, nov.sp.
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Thyreocephalus
Thyreocephalus macrophallus

description: Thyreocephalus macrophallus nov.sp.
M a t e r i a l s t u d i e d: Holotype: Yunnan, Nabanhe conv., Xishuangbanna, Hu & Tang 10.VII.2003 (SNUC).
D e s c r i p t i o n: Length of body about 12 mm; from anterior margin of head to posterior margin of elytra: 7 mm. Body black with reddish 6° visible abdominal segment and genital segment; antennae and legs brown. Head and pronotum and related puncturation as in Fig. 4. Labrum as in Fig. 5. Elytra sub-rectangular, narrow, longer that pronotum and as wide as the pronotum at the anterior angles, with sub-rectilinear and subparallel sides, and strictly marked humeral angles. Surface with well visible, dense puncturation, arranged in numerous series; the median serie oblique. Abdomen with very fine and dense, transverse micro-striation and well visible, not sparse puncturation, arranged in some series.
Tergite and sternite of the male genital segment as in Figs 6-7. Aedeagus (Fig. 8) very large, 2,6 mm long, of characteristic shape, with median lobe protruding and symmetrical parameres; inner sac tube-like, folded some time on itself, and enlarged in the proximal portion, covered by fine scales.
E t y m o l o g y: The specific epithet refers to the big size of the aedeagus.
G e o g r a p h i c a l d i s t r i b u t i o n: This species is known from the type locality only, in Yunnan.
 N o t e: The new species differs from T. yunnanus BORDONI 2007 by size, colouration, shape of the forebody, puncturation, and by the not flat body.
description: Published as part of Bordoni, A., 2013, New data on the Xantholinini from China. 24. New genus, new species and new records of the Shanghai Normal University collection (Coleoptera, Staphylinidae) 244 ° contribution to the knowledge of the Staphylinidae, pp. 1745-1797 in Linzer biologische Beiträge 45 (2) on pages 1748-1749, DOI: 10.5281/zenodo.10273196
Refractions: Queer History Cast Through Experimental Poetry
Creators: name: Meunier, Paul
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Poetry
subject: Queer
subject: Kinship
subject: Speculative Writing
subject: Experimental Writing
subject: Literature--English
subject: Language--Modern
subject: Anthropology--Cultural

description: Refractions, the creative manuscript in this dissertation, presents a long-form poetry narrative of the figurative being Thousand, born through refracted light in future Calgary, Alberta, that follows their search for family in an unfamiliar space. Divided into five “Movements” that emulate a symphony, Thousand’s search for their parentage reveals a familial fabric of queerness and kinship, beyond the nuclear family unit, as they slowly learn of the community network that surrounds them. In this future space, mothers and aunts create worlds like gods, characters forge bonds across thresholds of life and death, and queer parents represent a space for love, creation, and generative capacity, outside of traditional notions of progeny. Refractions is a story of queer kinship, chosen family, and ontological awakening. As Thousand learns where they come from, authorial memoirs are stored, illuminated, and shared within the site of the queer and future archive. By exploring multidirectional conduits between past and future, Thousand not only learns of where they come from and the formative powers of chosen family, but they discover their own language for queer identity, agency, and the capacity to pursue an undefined future. The critical exegesis presents a lineage of creative foundations and theoretical examinations that influence this manuscript. These include the short stories that weave antinarrative together in Wayde Compton’s The Outer Harbour, and the speculative fiction and mythmaking in Catherynne M. Valente’s Silently and Very Fast. Theoretical reflections underscore the importance of writing as community-situated, the politics of cultural appropriation, ethics and accountabilities. Refractions also considers the charge in José Esteban Muñoz’s pursuit for queer utopia, mindful of how Joan Retallack’s “The Poethical Wager” challenges writers to explore ethically and responsibly. In this way, Refractions considers how Thousand might hold their own space, agency, and limitless potential to pursue a Queer Poethics.
Machine learning reveals cyclic changes in seismic source spectra in Geysers geothermal field
Creators: name: Holtzman, Benjamin K.
name: Paté, Arthur
name: Paisley, John W.
name: Waldhauser, Felix
name: Repetto, Douglas I.
Publisher: name: Columbia University
Year: 2018
Subjects: Machine learning
Earthquake prediction--Statistical methods
Seismology

description: The earthquake rupture process comprises complex interactions of stress, fracture, and frictional properties. New machine learning methods demonstrate great potential to reveal patterns in time-dependent spectral properties of seismic signals and enable identification of changes in faulting processes. Clustering of 46,000 earthquakes of 0.3 < ML < 1.5 from the Geysers geothermal field (CA) yields groupings that have no reservoir-scale spatial patterns but clear temporal patterns. Events with similar spectral properties repeat on annual cycles within each cluster and track changes in the water injection rates into the Geysers reservoir, indicating that changes in acoustic properties and faulting processes accompany changes in thermomechanical state. The methods open new means to identify and characterize subtle changes in seismic source properties, with applications to tectonic and geothermal seismicity.
A Versatile Source of Single Photons for Quantum Information Processing
Creators: name: Förtsch, Michael
name: Fürst, Josef
name: Wittmann, Christoffer
name: Strekalov, Dmitry
name: Aiello, Andrea
name: Chekhova, Maria V.
name: Silberhorn, Christine
name: Leuchs, Gerd
name: Marquardt, Christoph
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The quantum state of a single photon stands among the most fundamental and intriguing manifestations of quantum physics. At the same time single photons and pairs of single photons are important building blocks in the fields of linear optical based quantum computation and quantum repeater infrastructure. These fields possess enormous potential and much scientific and technological progress has been made in developing individual components, like quantum memories and photon sources using various physical implementations. However, further progress suffers from the lack of compatibility between these different components. Ultimately, one aims for a versatile source of single photons and photon pairs in order to overcome this hurdle of incompatibility. Such a photon source should allow for tuning of the spectral properties (wide wavelength range and narrow bandwidth) to address different implementations while retaining high efficiency. In addition, it should be able to bridge different wavelength regimes to make implementations compatible. Here we introduce and experimentally demonstrate such a versatile single photon and photon pair source based on the physics of whispering gallery resonators. A disk-shaped, monolithic and intrinsically stable resonator is made of lithium niobate and supports a cavity-assisted triply-resonant spontaneous parametric down-conversion process. Measurements show that photon pairs are efficiently generated in two highly tunable resonator modes. We verify wavelength tuning over 100 nm between both modes with a controllable bandwidth between 7.2 and 13 MHz. Heralding of single photons yields anti-bunching with $g^{(2)}(0) < 0.2$. This compact source provides unprecedented possibilities to couple to different physical quantum systems and renders it ideal for the implementation of quantum repeaters and optical quantum information processing.
Speocera xuanson Li & Li 2019, sp. nov.
Creators: name: Tong, Yanfeng
name: Li, Fengyuan
name: Song, Yang
name: Chen, Haifeng
name: Li, Shuqiang
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Ochyroceratidae
Speocera
Speocera xuanson

description: Speocera xuanson Li & Li sp. nov. (Figs 51–52, 57I–J) Material examined. Holotype ♂ (IZCAS), Vietnam, Xuan Son National Park, Lun Cave (21º7.022′N, 104º57.443′E), elev. 398 m, 16.X.2012, leg. H. Zhao. Paratypes 2♂ 3♀ (IZCAS), same data as holotype. Etymology. The specific name is derived from the type locality; noun. Diagnosis. The new species is similar to S. bicornea Tong & Li, 2007, but males can be distinguished by the long associated sclerites of the embolus (Figs 51A–B) and females by the long afferent spermathecae extending to the upper sides of the abdomen (Figs 52B, D). S. bicornea males do not have the long associated sclerites of the embolus, and the females have short afferent spermathecae, not extending to upper sides of the abdomen (Tong & Li, 2007: fig. 7). Description. Male. Total length 1.10; carapace length 0.48; carapace width 0.43; abdomen length 0.58; abdomen width 0.40. Prosoma: carapace pyriform, narrowing gradually anteriorly; shiny, light yellow, suffused with brownish pattern (Fig. 52C); pars cephalica flat; fovea not visible. Sternum yellow, suffused with brown, as long as wide. Endites light yellow with serrula; labium light yellow. Clypeus nearly vertical; short. Chelicerae light yellow, laterally strongly excavated, with a small horn-shaped apophysis; promargin with a series of six teeth reaching the lamina; retromargin with two very small denticles (Figs 57I–J). Eyes: six contiguous eyes surrounded by black pigmentation; PME smallest; PLE largest (Fig. 52C). Opisthosoma oval; light brown. Legs missing. Genitalia (Fig. 51). Palpal femur long; palpal tibia as long as cymbium (Figs 51A–B). Cymbium conical, with large prolateral extension basally. Bulb spherical, wider than high. Embolus wide, dark and basally with one long associated sclerite; sperm duct initially very wide, gradually narrowing distally (Fig. 51D). Female. Total length 1.25; carapace length 0.51; carapace width 0.43; abdomen length 0.68; abdomen width 0.46. Similar to male in color and general features (Figs 52D–E) but larger. Chelicerae unmodified. Legs I, II, III missing; leg IV 2.06 (0.59, 0.15, 0.58, 0.42, 0.32). Genitalia. Internal genitalia with afferent spermathecae long, extending past the sides of the abdomen (Fig. 52B); spermathecae oval (Fig. 52A). Distribution. Known only from the type locality.
description: Published as part of Tong, Yanfeng, Li, Fengyuan, Song, Yang, Chen, Haifeng & Li, Shuqiang, 2019, Thirty-two new species of the genus Speocera Berland, 1914 (Araneae: Ochyroceratidae) from China, Madagascar and Southeast Asia, pp. 1-75 in Zoological Systematics 44 (1) on page 66, DOI: 10.11865/zs.201901, http://zenodo.org/record/5366923
Modeling and data analysis of emergent properties in different biological systems
Creators: name: Mandwal, Ayush Kumar
Publisher: name: Science
Year: 2024
Subjects: subject: Purkinje cells
subject: Memory
subject: Genetic divergent species
subject: Antibiotics
subject: Network visualization
subject: Microbiology
subject: FOS: Biological sciences
subject: Physics
subject: Biophysics
subject: Physics--Theory

description: Biological systems exhibit a wide array of rich and diverse emergent phenomena, resulting from the intricate modulation of interactions between their components. This modulation can involve changes in both the strength and nature of interactions, leading to complex behaviors and properties. To gain insights into these complex phenomena, various computational and modeling approaches are employed to decipher experimental observations and allow for a deeper understanding of the underlying mechanisms at play. This thesis aims to explore emergent properties in Neuroscience and Microbiology. In Neuroscience, connections between neurons are known to store memories, although it is not clear how. To investigate how memory forms and changes with learning locally between neurons, I proposed a novel molecular mechanism of temporal learning in the Cerebellum part of the brain and validated it using mathematical models. My investigations aimed to shed light on the fundamental processes that lie at the core of learning and cognitive function, providing a deeper understanding of how our brains acquire and learn from experiences. In Microbiology, the behavior of microbes is closely linked to their metabolism, which is often constructed from the genome sequence using algorithmic genetic annotation pipelines. However, these methods can leave gaps in the metabolic network, leading to incorrect interpretations of a pathogen’s metabolic capabilities and hindering therapeutic interventions. To address this, I developed the MINNO network analysis web application, which allows one to identify gaps and explore potential targets for drugs. As microorganisms continue to develop resistance to existing drugs, the need for novel drugs and therapeutic targets becomes increasingly pressing. Moreover, determining the targets of these novel drugs is crucial yet challenging. I addressed this issue using metabolic fingerprinting, which can classify known antibiotics based on the metabolic phenotype they induce in Escherichia coli. Additionally, I formulated an extension of kinetic flux profiling for perturbed cases to gain insights into cellular responses to antibiotics or other stresses in general. Due to their versatility and general applicability, both the MINNO and perturbed kinetic flux profiling are anticipated to enable novel insights into microbial metabolism and various complex biological phenomena observed in nature.
Single-epoch VLBI imaging study of bright active galactic nuclei at 2 and 8 GHz
Creators: name: Pushkarev, A. B.
name: Kovalev, Y. Y.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate statistical and individual astrophysical properties of active galactic nuclei (AGNs), such as parsec-scale flux density, core dominance, angular and linear sizes, maximum observed brightness temperatures of VLBI core components, spectral index distributions for core and jet components, and evolution of brightness temperature along the jets. Furthermore, we statistically compare core flux densities and brightness temperature as well as jet spectral indices of gamma-ray bright and weak sources. We used 19 very long baseline interferometry (VLBI) observing sessions carried out simultaneously at 2.3 and 8.6 GHz with the participation of 10 Very Long Baseline Array (VLBA) stations and up to 10 additional geodetic telescopes. The observations span the period 1998-2003. We present here single-epoch results from high-resolution radio observations of 370 AGNs. Our VLBI images at 2.3 and 8.6 GHz as well as Gaussian models are presented and analyzed. At least one-fourth of the cores are completely unresolved on the longest baselines of the global VLBI observations. The VLBI core components are partially opaque with the median value of spectral index of alpha_core=0.3, while the jet features are usually optically thin alpha_jet=-0.7. The spectral index typically decreases along the jet ridge line owing to the spectral aging, with a median value of -0.05 mas^-1. Brightness temperatures are found to be affected by Doppler boosting and reaching up to \sim10^13 K with a median of \sim2.5x10^11 K at both frequencies. The brightness temperature gradients along the jets typically follow a power law T_b\simr^-2.2 at both frequencies. 147 sources (40%) positionally associated with gamma-ray detections from the Fermi LAT Second Source Catalog have higher core flux densities and brightness temperatures, and are characterized by the less steep radio spectrum of the optically thin jet emission.
description: 15 pages, 21 figures, accepted by A&A on May 22, 2012, machine readable tables are available from the source of the paper
Learning Approaches in Post-Secondary Engineering Education – A Scoping Review
Creators: name: Raza, Kashif
name: Li, Simon
Publisher: name: Arts
Year: 2024

description: This scoping review is aimed at doing a survey of the learning approaches used by students in engineering education. These approaches could be directly employed by the students or impacted by the teaching strategies used by educators. There seem to be two dominant perspectives on student learning in the field: deep learning and surface learning. The former can be referred to as high-level learning and is highly supported and aimed by educators. The latter is perceived to be a less attractive approach and is often regarded as the opposite of deep learning where students do not necessarily understand a concept but can reproduce the target content during exams or other assessment tasks because they have memorized it. However, we believe that student learning can not always be categorized as deep or surface as there can be practices that fall in-between the two (pattern recognition, mental models, and free learning are some examples reported in the literature). What we intend to do in this scoping review is a survey of the existing approaches reported by the researchers so that we can 1) identify the types of learning approaches dominant in the field; 2) clarify how these approaches are understood and described in the literature; 3) identify and analyze knowledge gaps in the existing literature; and 4) propose a way forward for engineering education in the form of a theoretical framework that can guide future teaching and learning practices as well as research in the field of engineering education. Since there is scarcity of research on the learning approaches in the field of engineering education, a scoping review was considered appropriate to determine what evidence exists on the topic and what “more specific questions can be posed and valuably addressed by a more precise systemic review” (Munn et al., 2018, p. 2).
The Lyric West : reading the Vancouver Poetry Society, 1916-1974
Creators: name: Hurley, Grant
Publisher: name: University of British Columbia
Year: 2012

description: The first Canadian society formally devoted to poetry was founded in Vancouver, British Columbia by six local hobby poets on 21 October 1916. Over the course of nearly sixty years, the Vancouver Poetry Society (VPS) matured into a formidable cultural institution, hosting numerous readings, lectures, plays, gala nights, a radio programme and several publishing enterprises. These activities were supported by an exceptional membership of influential Canadian poets: romantics Charles G.D. Roberts and Bliss Carman in the early years of the Society, and later, modernist poets Dorothy Livesay, Al Purdy, and Pat Lowther, among a wide variety of poets, artists, publishers, and playwrights. I argue that the history of the Vancouver Poetry Society is framed by a constant struggle to generate and maintain cultural authority and distinction in the contested spaces of Canadian literature. Produced by the VPS through the mediation of local and national literary publics with its internal politics and aesthetics, its authority functioned only in conjunction with the vibrant, multivocal circulation of varied and often contradictory literary discourses within its ranks. I document Society efforts to establish authority through an examination of its early history and changes in institutional frameworks into the 1930s, including the appropriation of literary celebrities in the persons of Carman and Roberts, and the adherence to the spiritual and critical language of Theosophy as an ultimate guiding authority. Secondly, I narrate the Society’s accommodation and cautious encouragement of modernism. Finally, I briefly trace the Society’s loss of cultural capital after its increasingly consistent disavowal of modernism.
Thyreocephalus pseudolorquini Bordoni, 2013, nov.sp.
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Thyreocephalus
Thyreocephalus pseudolorquini

description: Thyreocephalus pseudolorquini nov.sp.
M a t e r i a l s t u d i e d: Holotype: Yunnan, Manfei, Nabanhe conv., Li & Tang 9.I.2004 (SNUC).
D e s c r i p t i o n: Length of body about 14 mm; from anterior margin of head to posterior margin of elytra: 7,5 mm. Body black with red elytra; scutellum black and small; 6° visible abdominal segment a little reddish; genital segment, antennae and legs reddish. Head and pronotum and related puncturation as in Fig. 14. Head and pronotum shiny. Labrum as in Fig. 15. Elytra sub-rectangular, a little longer and wider than pronotum, slightly dilated posteriad, with scarcely marked humeral angles. Surface with fine puncturation, arranged in three series, one near the suture, one median and one lateral. Abdomen with very fine and dense, transverse micro-striature and well visible puncturation, dense on the sides.
Tergite and sternite of the male genital segment as in Figs 16-17. Aedeagus (Fig. 18) 1,1 mm long; median lobe evident, with rounded apex; inner sac tube-like, extremely narrow and long.
 E t y m o l o g y: The specific epithet refers to the similar colouration of T. lorquini (FAUVEL 1877) from Moluccas, Sulawesi and Australia (BORDONI 2002, 2005a).
G e o g r a p h i c a l d i s t r i b u t i o n: This species is known from the type locality only, in Yunnan.
 N o t e: The new species differs from T. lorquini by more narrow body, smaller head, puncturation of head and elytra, and by the aedeagus.
description: Published as part of Bordoni, A., 2013, New data on the Xantholinini from China. 24. New genus, new species and new records of the Shanghai Normal University collection (Coleoptera, Staphylinidae) 244 ° contribution to the knowledge of the Staphylinidae, pp. 1745-1797 in Linzer biologische Beiträge 45 (2) on pages 1749-1750, DOI: 10.5281/zenodo.10273196
Rethinking Grand Strategy for an Era of Climate Change
Creators: name: Verklan, Christopher
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Climate change
subject: grand strategy
subject: Pakistan
subject: resources
subject: food security
subject: water security
subject: energy security
subject: History--Modern
subject: History--Military
subject: Military Studies
subject: Political Science--International Law and Relations

description: The strategic security environment has changed drastically over the last decade, with the passing of the American unipolar moment leading to the beginnings of a new era of strategic inter-state competition. However, unlike past eras of competition, this iteration will see states compete within an increasingly destabilized climate system because of climate change. This thesis explores how the impacts of climate change will shape the upcoming era of competition, focusing on its effects on grand strategy, given the latter’s important role as a ‘bridge’ that links the means and ways of a state to its ends. In particular, the central question addressed by this thesis is as follows: Do the observed global environmental changes because of climate change necessitate the broadening of the geographic understanding of grand strategy? This thesis argues that climate change has and will continue to impact the conduct of strategy in the future. It also argues that climate change must be explicitly incorporated into modern understandings of grand strategy given its ability to undermine the economic underpinnings of states that enable the pursuit of their goals in a feasible and sustainable manner. In making this argument, this thesis develops a conceptual framework linking climate change through to the implementation of grand strategy, using the case of the 2022 Pakistani floods as a demonstrative case study to show how climate change can generate significant impacts on the grand strategies of states.
Additional file 1 of Personalized analysis of minimal residual cancer cells in peritoneal lavage fluid predicts peritoneal dissemination of gastric cancer
Creators: name: Zhao, Dongbing
name: Yue, Pinli
name: Wang, Tongbo
name: Wang, Pei
name: Song, Qianqian
name: Wang, Jingjing
name: Jiao, Yuchen
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Materials and Methods.
On Delta resonance contribution to two-photon exchange amplitude
Creators: name: Borisyuk, Dmitry
name: Kobushkin, Alexander
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We consider two-photon exchange (TPE) in the elastic electron-proton scattering and study the contribution arising from the production of Delta(1232) resonance in the intermediate state. We calculate all three TPE amplitudes (generalized form factors), and find that the Delta contribution mainly influences generalized electric form factor (contrary to the elastic contribution, which affects magnetic form factor), and the effect grows with Q^2. If the corresponding correction is applied to the recent polarization transfer measurements of proton form factors, their results will change markedly. Thus we suggest that TPE corrections due to inelastic intermediate states are important to polarization experiments at high Q^2, and should not be neglected.
description: 6 pages, 7 figures; Eq.(13) corrected, Fig. 5 changed, other minor changes; to be published in Phys.Rev.C
Controlling the Conversation: The Ethics of Social Platforms and Content Moderation
Creators: name: Bengani, Priyanjana
name: Ananny, Mike
name: Bell, Emily J.
Publisher: name: Columbia University
Year: 2018
Subjects: Journalism
Online journalism
Journalistic ethics
Social media

description: With social platforms’ prevailing dominance, there are numerous debates around who owns information, content, and the audience itself: the publisher, or the platform where the content is discovered—or not discovered, as the case may be. Platforms rely heavily on algorithms to decide what to surface to their users across the globe, and they also rely on algorithms to decide what content is taken down. Meanwhile, publishers are making similar decisions on a significantly smaller scale, and not necessarily algorithmically or quite as generically. But how are any of these decisions made? And what are the various factors taken into account to ensure that the decision-making is fair and ethical? On February 23, 2018, the Tow Center for Digital Journalism at Columbia University and the Annenberg Innovation Lab at USC Annenberg School for Communication and Journalism hosted a Policy Exchange Forum followed by a conference on the topic of “Controlling the Conversation: The Ethics of Social Platforms and Content.” The Policy Exchange Forum was a closed-group discussion that followed the Chatham House Rule. The discussion broadly focused on three topics: “Ethics of Moderation”, “Moderation Tools”, and “Technological Challenges.”
Proteomic and transcriptomic analysis of clinical and in vitro flow-exposed breast cancer samples reveals pathways and markers relevant to postpartum breast cancer.
Creators: name: Stibbards-Lyle, Maya
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Breast cancer
subject: Postpartum health
subject: Proteomics
subject: Transcriptomics
subject: Fluid shear stress
subject: Bioreactor
subject: Engineering--Biomedical

description: Mechanical forces are an important, yet poorly understood, influence on the metastatic capability of breast cancer cells. They exist in a dynamic interplay with the structural and immune aspects of the cancer microenvironment. Mammary gland involution is a remodeling process that occurs post-lactation and is believed to be responsible for poor outcomes observed in postpartum breast cancer. Fluid shear stress is well-linked to tissue remodeling and is likely increased during this stage of the postpartum period. In this thesis, a bioreactor system was combined with hormonal treatment to expose breast cancer cells to some of the conditions relevant to postpartum involution. We initially validated the model by studying the morphology and viability of cells upon exposure to fluid shear stress and involution and confirming the presence of relevant protein markers. Using machine learning-based analysis of publicly available RNA-seq datasets, we identified numerous genes and pathways upregulated in both postpartum and flow-exposed conditions. We further validated these findings using proteomic analysis of flow-exposed MDA-MB-231 breast cancer cells, which identified similar proteins and pathways to the initial transcriptomic analysis. These included pathways linked to inflammation, wound healing, cell migration, and extracellular matrix organization, which are all pathways critically involved in the action of mammary gland involution. Further investigation revealed that matrix metalloproteinases, a key promoter of the remodeling activities and tumorigenic effect of involution, are significantly upregulated upon exposure to fluid flow. Proteomic analysis of MCF-7 cells treated with hormones associated with lactation revealed markers and pathways related to immune-mediated progression of breast cancer. Finally, we established the utility of our model by validating that the protein expression of chemokine C-X-C motif ligand 13 (CXCL13), which was upregulated in our transcriptomics analysis and is a well-established marker of breast cancer metastasis in young patients, is upregulated in response to flow-exposure. This suggests that our model serves as an efficient method to identify relevant breast cancer biomarkers related to the mechanism of mammary gland involution. To our knowledge, these studies are the first to integrate hormonal and fluid shear stress influences in the context of breast cancer, and to suggest a link between fluid shear stress and mammary gland involution. They serve as an initial proof of concept, indicating that fluid shear stress could serve as a powerful tool in furthering our understanding of postpartum breast cancer and identification of relevant biomarkers for this unique cohort.
Spin Hall effect in iron-based superconductors: A Dirac-point effect
Creators: name: Pandey, Sudhakar
name: Kontani, Hiroshi
name: Hirashima, Dai S.
name: Arita, Ryotaro
name: Aoki, Hideo
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We have theoretically explored the intrinsic spin Hall effect (SHE) in the iron-based superconductor family with a variety of materials. The study is motivated by an observation that, in addition to an appreciable spin-orbit coupling in the Fe 3d states, a character of the band structure in which Dirac cones appear below the Fermi energy may play a crucial role in producing a large SHE. Our investigation does indeed predict a substantially large spin Hall conductivity in the heavily hole-doped regime such as KFe$_2$As$_2$. The magnitude of the SHE has turned out to be comparable with that for Pt despite a relatively small spin-orbit coupling, which we identify to come from a huge contribution from the gap opening induced by the spin-orbit coupling at the Dirac point, which can become close to the Fermi energy for the heavy hole doping.
description: 5 pages, 4 figures
Achmonia nigra
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Achmonia
Achmonia nigra

description: Achmonia nigra (BORDONI 2009)
M a t e r i a l s t u d i e d: Zhejiang, Longwang-shan N. P., Dongguan, 1250 m, Feng, Liu, Yuan & Yin 26.V.2009, 1 (SNUC).
G e o g r a p h i c a l d i s t r i b u t i o n The species, described from Zhejiang (Tianmu Shan) (BORDONI 2009d), is known from this county only. This is the first subsequent record of the species since it was described.
 N o t e: The genus Achmonia BORDONI 2004 (= Daolus BORDONI 2004) was described for a species from Java.
 By studying species of Thyreocephalus, I realized that some of them should be transferred to the genus Achmonia. The genus Achmonia seems to have a distribution similar to that of Thyreocephalus, even if the currently known species are still few. This genus is kown until now from NE India, Nepal, Sikkim, Bhutan, Burma, Thailand, Laos, Malaysia, Java, Taiwan, Australia, and China: Zhejiang (BORDONI 2012c). In these pages the genus Achmonia is cited also from Yunnan, Hainan and Jiangxi.
description: Published as part of Bordoni, A., 2013, New data on the Xantholinini from China. 24. New genus, new species and new records of the Shanghai Normal University collection (Coleoptera, Staphylinidae) 244 ° contribution to the knowledge of the Staphylinidae, pp. 1745-1797 in Linzer biologische Beiträge 45 (2) on page 1750, DOI: 10.5281/zenodo.10273196
Radar and INS Integration for Enhancing Land Vehicle Navigation in GNSS-Denied Environment
Creators: name: Elkholy, Mohamed
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Autonomous Navigation
subject: INS
subject: Radar
subject: Radar/INS Integration
subject: EKF
subject: Tightly Coupled Integration
subject: Loosely Coupled Integration
subject: Engineering--Automotive

description: Nowadays, recent research is interested in autonomous navigation applications. GNSS/INS integration is the most common integration technique to estimate the vehicle navigation state with high accuracy. However, the GNSS/INS fusion technique is not reliable in different environments since the GNSS signal suffers from multipath errors in the downtown area, or the GNSS signal could be blocked in underground parking or indoors. In case of a GNSS signal outage, the navigation system will rely on INS as a standalone solution. INS can estimate the vehicle’s navigation states (position, velocity, and attitude) with high accuracy. However, the INS solution deteriorates with time because of the INS drift. Therefore, other sensors are used to aid IMU in correcting the IMU drift and estimate the vehicle’s navigation states with high accuracy. Vision, Light Detection and Range (LIDAR), odometer can be used to aid INS. However, each sensor has some limitations since these sensors cannot work in different light and weather conditions. Motion constraints, e.g., non-holonomic constraints (NHC), Zero velocity Update (ZUPT), and zero integrating heating rate (ZIHR), can improve the vehicle’s position and limit the IMU drifts. Radio Detection and Ranging (Radar) is known as an all-weather sensor since it can work in different light and weather conditions. Radar is mainly used as Adaptive Cruise Control (ACC) to estimate the range and relative speed of the front vehicle. In terms of continuity, radar, and IMU are the only two sensors that can work in different weather and light conditions to estimate the vehicle’s position. Therefore, this research is focused on the integration between radar and IMU for land vehicle navigation applications. A 360-degree radar was utilized to detect the surrounding objects. Oriented Fast and Rotated Brief (ORB) was adopted to detect and match the features between radar frames. The matched features were exploited to estimate the transition and rotation between radar frames. Then, the radar solution is integrated with INS to improve the navigation solution. Another technique applied in this research to find the corresponding features between radar frames was developed. With the help of the corresponding points, the vehicle’s ego-motion can be estimated. Frequency Modulated Continuous Wave (FMCW) radar was used in this research to estimate the vehicle’s forward speed using the Doppler frequency information. Finally, tightly coupled integration between FMCW radar and IMU was applied to improve the vehicle’s navigation states.
Radial mode dependence of optical beam shifts
Creators: name: Hermosa, N.
name: Aiello, Andrea
name: Woerdman, J. P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: It is known that orbital angular momentum (OAM) couples the Goos-Hanchen and Imbert-Fedorov shifts. Here, we present the first study of these shifts when the OAM-endowed LG(l,p) beams have higher-order radial mode index (p>0). We show theoretically and experimentally that the angular shifts are enhanced by p while the positional shifts are not. Since LG(l,p) modes form a complete basis set for paraxial beams, our results can be used to predict beam shifts of arbitrary modes of light.
description: Accepted for publication in Optics Letters
NOTARY IN CIVIL PROCEEDINGS IN UZBEKISTAN
Creators: name: Karimova, Madina
name: Khurramov, Oybek
Publisher: name: Zenodo
Year: 2023

description: The notary, as one of the important institutions that ensures the rights of individuals and legal entities, performing the functions of preventive justice and the prevention of legal disputes, became one of the first legal institutions of the Republic of Uzbekistan that underwent optimization. In particular, we are talking about the difference between cross-border and national legal requirements regarding the execution of documents, the need or absence of the need to certify individual documents, the procedure for their execution and other differences
The Influence of Co-teaching on Marginalized Elementary Students’ Mathematics Performance
Creators: name: Papoff, L R Ruth
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Co-Teaching
subject: Marginalized Students
subject: Assessment
subject: Cultural Historical Activity Theory (CHAT)
subject: Education--Mathematics
subject: Education--Elementary
subject: Education--Curriculum and Instruction

description: This single case study explores the influence of co-teaching on marginalized elementary student performance in mathematics. Marginalized communities historically perform poorly on standardized tests. There is a need for an intervention model that responds to the diverse needs of marginalized populated classrooms. Co-teaching is a model of teaching that supports a greater ability to personalize learning and support complex diverse classrooms. Whilst co-teaching has been shown to be effective, there is little research on how co-teaching influences students’ learning. When assessing students, authentic assessment has been shown to support the learning and sensemaking process for learners, as opposed to a standardized test. Thus, it is important that this study integrated understanding student success within a co-taught classroom by incorporating authentic assessment compared to a standardized test. The study explored the instructional processes that linked co-teaching to students’ mathematics performance using qualitative and quantitative data. To gain an in-depth understanding of the complex dynamics of a co-taught classroom, the Cultural Historical Activity Theory (CHAT) was utilized to guide data analyses. The CHAT framework encapsulates a sociocultural constructivist understanding which corresponds to the diverse marginalized population within the co-taught classroom. The analysis established from these methods offered a comprehensive insight of co-teaching mathematics processes that directly influenced students’ mathematics learning and performance. The findings from this exploratory case study highlight three major themes. The first thematic finding was that co-teaching allowed for flexible group work to personalize learning. The second thematic finding was that time and space were shared between co-teaching and assessment, allowing for more formative assessment that was in real-time and ongoing. This led to the co-teachers’ perceived professional learning in assessment practices. The final thematic finding was that although there were low expectations from the co-teachers, student participants achieved a higher level of mathematics performance. The higher level of mathematics performance amongst marginalized students compared to the low expectations of their teachers may attribute to the co-taught environment that enabled flexible group work and formative assessment.
Dwarfs Gobbling Dwarfs: A Stellar Tidal Stream Around NGC 4449 and Hierarchical Galaxy Formation on Small Scales
Creators: name: Martinez-Delgado, David
name: Romanowsky, Aaron J.
name: GaBany, R. Jay
name: Annibali, Francesca
name: Arnold, Jacob A.
name: Fliri, Juergen
name: Zibetti, Stefano
name: van der Marel, Roeland P.
name: Rix, Hans-Walter
name: Chonis, Taylor S.
name: Carballo-Bello, Julio A.
name: Aloisi, Alessandra
name: Maccio, Andrea V.
name: Gallego-Laborda, J.
name: Brodie, Jean P.
name: Merrifield, Michael R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: A candidate diffuse stellar substructure was previously reported in the halo of the nearby dwarf starburst galaxy NGC 4449 by Karachentsev et al. We map and analyze this feature using a unique combination of deep integrated-light images from the Black Bird 0.5-meter telescope, and high-resolution wide-field images from the 8-meter Subaru telescope, which resolve the nebulosity into a stream of red giant branch stars, and confirm its physical association with NGC 4449. The properties of the stream imply a massive dwarf spheroidal progenitor, which after complete disruption will deposit an amount of stellar mass that is comparable to the existing stellar halo of the main galaxy. The ratio between luminosity or stellar-mass between the two galaxies is ~1:50, while the indirectly measured dynamical mass-ratio, when including dark matter, may be ~1:10-1:5. This system may thus represent a "stealth" merger, where an infalling satellite galaxy is nearly undetectable by conventional means, yet has a substantial dynamical influence on its host galaxy. This singular discovery also suggests that satellite accretion can play a significant role in building up the stellar halos of low-mass galaxies, and possibly in triggering their starbursts.
description: ApJ Letters, in press. Minor changes. 6 pages, 3 figures. A high resolution version of the paper and Subaru image are available at http://www.cosmotography.com/images/small_ngc4449.html