cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ТЕРМИНОСИСТЕМА РОДСТВА КАК ОДИН ИЗ БАЗОВЫХ ЭЛЕМЕНТОВ ЯЗЫКОВОЙ КАРТИНЫ МИРА
Creators: name: Убайдуллоева Наргиза учительница русского языка ПК №1 Ташкентского района
Publisher: name: Zenodo
Year: 2024

description: Исследование терминологии родства в современной лингвистике представляет собой интерес, так как в них находят свое отражение взаимоотношения между людьми в обществе. Говоря о русской культуре, стоит отметить, что термины родства хранят в себе многовековую историю русского народа, что обуславливает необходимость изучения терминов родства как одной из самых ранних форм выражений отношений в обществе. Но, к сожалению, на сегодня данная область исследований все еще остается недостаточно раскрытой.
Image contrast in mirror and low energy electron microscopy
Creators: name: Kennedy, Shane Michael
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: We develop several approaches to understand and interpret image contrast in mirror electron microscopy (MEM) and low energy electron microscopy (LEEM), with potential applications to photoemission electron microscopy (PEEM). We treat both the forward problem, of how surface features and properties create image contrast, and the inverse problem, of how we may infer quantitative information about surface features and properties from experimental MEM, LEEM and PEEM images. The thesis begins with the development of the Laplacian imaging theory of MEM, whereby image contrast is understood as the second derivative of the surface topography, blurred slightly to account for the interaction of the electron beam with the electric field above the specimen, rather than the specimen surface itself. This intuitive method includes the effects of lens aberrations and can be rapidly inverted to recover the surface topography from experimental MEM images. For specimen surface variations that are outside the regime of the Laplacian imaging theory and other models, we develop a caustic imaging theory for MEM. This involves solving the electric field above the specimen and tracing a family or envelope of rays through the immersion lens. Where initially adjacent rays cross, caustics are created, and these strong image features may be used to recover three dimensional surface topography. Both the Laplacian imaging theory and the caustic imaging theory are successfully applied to experimental MEM data to obtain the surface topography. As a complement to this ray-based treatment, we then develop a wave optical treatment of LEEM image contrast, adopting the complex transfer function methodology from transmission electron microscopy. This method includes spherical and chromatic aberration, and may be extended to include higher order aberrations for use in aberration corrected LEEM instruments. With knowledge of the complex transfer function, we then apply phase retrieval methods to simulated LEEM images, recovering the electron wave function and surface topography for a series of step terraces. Finally, we consider a wave optical treatment of MEM, investigating the behaviour of the electron wave in the vicinity of the turn around region. This is extended to explore the application of MEM beyond specimen surfaces, and the feasibility of imaging very weak potentials, such as the ponderomotive potential experienced by an electron in a light field.
ОБЩИЕ ЧЕРТЫ ОТЕЧЕСТВЕННОЙ И ЗАПАДНОЕВРОПЕЙСКОЙ ПОЛИТИКО-ПРАВОВОЙ МЫСЛИ XVIII – ПЕРВОЙ ПОЛОВИНЫ XIX ВЕКА О ПРАВОСУДИИ
Creators: name: Аниканов Артем Константинович
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: эпоха Просвещения
правосудие
суд
разделение властей
общественный договор
естественное право

description: Введение: актуальность тематики статьи подтверждается не теряющим своей остроты интересом к творчеству западноевропейских философов-просветителей; кроме того, в научном сообществе не утихают споры по поводу самостоятельности отечественных идеологем рассматриваемого периода. Цель: исследование воздействия политико-правовых воззрений западноевропейских просветителей Ш.Л. Монтескье, Ф.-М. Вольтера, Ж.-Ж. Руссо, П.А. Гольбаха и других на отечественную общественную мысль о правосудии. Методическая основа: использовались исторический, контекстный методы, а также метод сравнительного анализа. Результаты: анализ воззрений западноевропейских просветителей показал, что влияние последних на отечественную политико-правовую мысль о правосудии особенно ярко проявилось по трем направлениям: место и роль судебной власти в связи с теорией разделения властей, обоснование правосудия моделью общественного договора и соотношение правосудия как государственной функции с идеей естественного права. Вывод: воззрения на правосудие отечественных мыслителей и государственных деятелей XVIII – второй половины XIX вв., несмотря на безусловное влияние идей европейских философов-просветителей Европы, представляют собой не прямое заимствование политико-правовой мысли Европы, а являются ее органичной частью за счет творческой переработки просветительских идеологем исходя из российских реалий.
Male help-seeking behaviour : why men access and continue with mental health counselling treatment
Creators: name: Meister, Peter
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Men’s health is a national concern in Australia in part because men’s morbidity and mortality rates are higher than the women’s. Men’s health has entered public awareness in Australia as well as in US, UK and Europe in recent years because of growing concerns about male’s poor health compared to females. Mental health is the 3rd biggest disease burden in Australia behind the cancers and coronary diseases. Men experience mental health problems as frequently as women and have an almost four times higher rate of suicide in Australia and other developed countries. At the same time men seek help for their mental health problems much less often than women. Men usually delay help-seeking for a very long time and when they eventually access mental health counselling services they often leave treatment quickly. This study investigated the triggers for men to access a mental health service and the factors underpinning their adherence to treatment regimens. In a qualitative, exploratory study, twenty male clients of a mental health counselling service were interviewed, and a grounded theory method was used to analyse the participants’ experiences. Additionally a focus group of mental health counselling professionals from the same service were also interviewed. The reports of the 20 males were then compared with the recounted experiences of professionals with their clients. It emerged that the severity of the men’s mental health or the functional disability is the decisive factor for accessing mental health treatment. This applies independently of prior experiences with mental health issues or mental health services. The study found that men delay help-seeking for a prolonged period, often until they are in a severe crisis, and when they eventually do access a service they do so with great ambivalence. Hence it was concluded that men may benefit from more rapid access to mental health counselling services. Results suggest that if men were educated about mental health and treatment facilities, the stigma could be reduced and male help-seeking could be improved. To ensure their adherence to treatment, specific characteristics of men should be considered. Variables affecting continuation of treatment include influence of others, hope, and the relationship with the counsellor, the perception of progress, counselling methods and costs. The study confirmed that GPs are the most important gatekeepers in the help-seeking process for mental health issues. The study indicates that GPs and other referrers should consider male specific characteristics. The study suggests that men have difficulties in recognising their problems as mental health issues; they have difficulties in talking about their feelings, and underestimate their mental health issues. Therefore referrers ought to be able to detect and diagnose mental health problems even if they are not immediately apparent or acknowledged as such by the male client.
ЕВГЕНИЧЕСКИЕ ИДЕИ В УГОЛОВНОЙ АНТРОПОЛОГИИ РОССИИ В КОНЦЕ XIX – НАЧАЛЕ XX ВЕКА
Creators: name: Горячева Татьяна Сергеевна
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: евгеника
уголовная антропология
наследственность
профилактика преступности
криминология

description: Введение: рассматривается влияние медицинских и антропологических исследований на развитие уголовно-правовой науки. Раскрывается содержание криминальной антропологии, представленной в России такими учеными, как П.Н. Тарновская, В.Ф. Чиж, Д.А. Дриль и др. Цель: дать оценку воздействия евгеники на взгляды представителей уголовной антропологии в России в конце XIX – начале XX в. Методологическая основа: использовались как общенаучные, так и специальные методы исследования, среди которых анализ, синтез, формально-юридический, историко-правовой и др. Результаты: на основе работ дореволюционных и современных ученых, анализируются взгляды отечественных исследователей на взаимодействие генетических факторов и условий внешней среды и их влияние на преступное поведение человека. Вывод: евгенические идеи, связанные с возможностью улучшения природных качеств человека, были восприняты представителями антропологического направления в уголовном праве России, предлагавшими осуществлять профилактику преступности с помощью медицинских мероприятий, направленных на борьбу с алкоголизмом и уменьшение болезней, передающихся по наследству.
A piezoelectric ultrasonic micro-motor for In Vivo micro-robots
Creators: name: Watson, Brett
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: A need for improvement in minimally invasive surgical techniques is well documented. A method of achieving this improvement is through the development of a tetherless micro-robot capable of conducting medical procedures in vivo. Such a device could circumvent many of the problems associated with current minimally invasive procedures, and ultimately, may carry out procedures previously impossible and open up new areas of treatment. A key obstacle that must be overcome in the development of such a device is the realisation of a motor capable of acting as the drive system. Such a motor needs to be approximately 200 um in diameter, produce a start-up torque in excess of 15 nNm/mm^2, and produce an output power of more than 65 uW/mm^2. Existing micro-motors have separately met the geometric or performance requirements, but never both. In this thesis, we report a design methodology that results in a piezoelectric ultrasonic resonant micro-motor that, for the first time, effectively meets these requirements. The design methodology of the motor uses the piezoelectric element as a vibration generator, rather than as an integral part of the stator design. This simplifies the design, resulting in a reduction in size compared with existing micro-motor designs. The application of this methodology requires a stator design that can produce an elliptical stator tip motion from a single excitation source through resonant frequency matching. The design of such a stator is achieved through the development of three novel modelling techniques, which facilitate an understanding of how the system geometric parameters affect the resonant frequencies of interest, and affect the generation of the desired elliptical stator tip motion. The resulting motor has a stator dimension of 241 um and an overall diameter of 400 um, the larger dimension resulting from the commercial availability of magnetic elements. The peak measured start-up torque was 230.4 nNm/mm^2, with a peak output power of 72.4 uW/mm^2. This exceeded the requirements for torque and power to drive a tetherless micro-robot by 15-times and 10%, respectively. By overcoming the challenge of the drive system design, this work has opened up the opportunity to progress to the next stage of research in in vivo micro-robotics, full prototype development.
Development of photocathodes for incorporation into tandem dye sensitised solar cells
Creators: name: Nattestad, Andrew
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The widespread application of photovoltaics, directly converting of solar energy to electrical, has not been realised, in spite of being a favoured power source by many. In order to make them more economically viable new solar technologies are being developed, with an emphasis on low cost and simple production processes. The dye sensitised solar cell is part of this category, however the efficiency of this technology is relatively low. One approach to improve this efficiency is to create a tandem architecture, with two active layers (in this case a photoanode and photocathode). This concept was demonstrated a little over a decade ago, and to date the photocathode is the limiting element in the quest for a high efficiency tandem dye sensitised solar cell. This thesis aims to gain a better understanding into the photocathode, and to improve overall performance.
The Shakuhachi and the Didjeridu : two case studies of historical iconology, performance practice and their relation to avian respiration and song
Creators: name: Rubin, Lauren
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis provides case studies of two end-blown instruments: the didjeridu, an Australian Aboriginal horn, and the shakuhachi, a Japanese flute, focusing on the correlation between avian symbology, respiration and song and each instruments’ performance practices and history. Both instruments are depicted using avian iconology in the ancient art of their respective cultures: the rock art of the Northern Territory and the mandala art of Shingon Buddhism. Using a broad range of interdisciplinary data the thesis argues and concludes that the use of avian symbology was purposeful rather than coincidental, citing multiple analogies between avian respiration and song and each instruments’ playing methods and performance practices. Further, ancient avian iconology present in the Taizōkai mandala provides evidence of the early history of the shakuhachi as a hōki, or spiritual tool, of Shingon Buddhism. These findings provide an alternative to the specious legend used by the Fuke sect about the shakuhachi’s early history, and give new evidence that the shakuhachi was first a tool of Shingon Buddhism before it was a tool of Zen.
Additional file 1: of Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity
Creators: name: Elango, Tamilselvi
name: Sun, Jingying
name: Zhu, Caihong
name: Zhou, Fusheng
name: Zhang, Yaohua
name: Sun, Liangdan
name: Yang, Sen
name: Zhang, Xuejun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S1. Comparison of the identified K14 and K10 nucleotide sequences of mild psoriasis obtained in this study with those of respective NCBI CDS sequences using BioEdit software (version 7.2). The mutated sequences are indicated by red arrows. Figure S2. Comparison of the identified K14, K10, K16, and K17 nucleotide sequences of moderate psoriasis obtained in this study with those of respective NCBI CDS sequences using BioEdit software (version 7.2). The mutated sequences are indicated by red arrows. (PDF 11608Â kb)
A method for the characterisation of gold nano-rods
Creators: name: Katz-Boon, Hadas
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Interest in gold nanorods derives from their unique optical properties, which strongly depend on both the particle size and shape. Many questions remain as to the relationship between the shape and optical properties of the nanorods. In addition, the anisotropic growth mechanism, which drives a crystal structure with cubic symmetry to grow into a rod, remains a mystery. In order to address these issues, there is a need to characterize the shape of the nano-rods in three dimensions (3D). A challenge for transmission electron microscopy (TEM) is to determine 3D shapes of particles from 2D images. Established tomography methods for reconstructing the 3D morphology of materials require a large number of images which is a time-consuming task. In the specific case of Au nanorods, there is a need for a more rapid method that can survey the 3D shape of a large number of particles to obtain good statistics in the comparison with their properties. This work will describe the development of a novel method to measure the thickness of a nanorod in the direction parallel to the incident beam from high angle annular dark field scanning transmission electron microscope (HAADF-STEM) image intensities, providing a map of thickness versus position across the nanorod – a “thickness projection image”. This method requires measurement of absolute intensity scattered to a fully characterised HAADF detector, so that an appropriately normalized HAADF image is obtained by correlation with the incident beam intensity. The relationship between intensity and specimen thickness is provided by HAADF image simulations, where dynamical elastic scattering, followed by single thermal diffuse scattering is taken into account. The rapidity of this method makes it an attractive new tool for the characterization of many nano-scale structures. Furthermore, in principle a 3D reconstruction can be achieved from only two thickness projection images at different orientations. The algorithm required to achieve this, and the practical issues affecting its experimental execution, are described here. This novel method was applied here to the characterization of gold nanorods. The detailed shape and crystallographic orientation of the surface facets of these nanorods was determined and found to differ from popular hypotheses. This may provide new insights into the growth mechanism of these nanorods.
ЗАКОНОДАТЕЛЬНОЕ РЕГУЛИРОВАНИЕ ОХРАНЫ ПРАВ БЕРЕМЕННЫХ ЖЕНЩИН И ЖЕНЩИН-МАТЕРЕЙ В РОССИИ В СЕРЕДИНЕ XIX – НАЧАЛЕ XX ВЕКА
Creators: name: Мун Виктория Анатольевна
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: охрана материнства
охрана детства
внебрачные дети
денежное содержание детей
женщины-арестантки
уголовно-правовая охрана материнства и детства.

description: Введение: в статье раскрывается процесс становления и развития законодательного регулирования охраны прав беременных женщин и женщин, имеющих малолетних детей в России в середине XIX – начале XX вв., выделяются основные направления государственно-правовой охраны в данной области. Цель: раскрыть характер законодательного регулирования охраны прав беременных женщин и женщин, имеющих малолетних детей, выделить основные направления государственно-правовой охраны материнства и детства в России в середине XIX – начале XX вв. Методологическая основа: диалектический метод научного познания, историко-правовой метод, сравнительный метод исследования. Результаты: показано, как происходил процесс эволюции законодательного регулирования в области охраны прав беременных женщин и женщин с малолетними детьми, выделены основные направления государственноправовой охраны материнства и детства в России в середине XIX – начале XX вв. Выводы: в основе российского законодательства о браке и семье конца XIX в. – начала XX в. лежали традиции патриархальной семьи, в силу которых материнская власть в семье была подчинена власти отцовской. Сообразно указанным представлениям выстраивались права беременных женщин и женщин, имеющих детей в законном, незаконном браке и браке, признанном недействительным. Значительное внимание к охране прав беременных женщин и женщин, имеющих малолетних детей в уголовном законодательстве России середины XIX – начала XX вв. обуславливалось физической слабостью женщин, особенно в периоды беременности и кормления ребенка.
К ВОПРОСУ О ФОРМИРОВАНИИ ПОНЯТИЯ «ЗАКОННЫЙ ИНТЕРЕС» В ЮРИДИЧЕСКОЙ НАУКЕ
Creators: name: Чернышов Андрей Викторович
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: законный интерес
субъективное право
свободы
правовая система
охраняемый законом интерес
юридически значимый интерес

description: Введение: отсутствие легально закрепленного определения законного интереса как на законодательном уровне, так и на уровне теоретическом подтверждает актуальность данной темы и порождает необходимость более тщательного изучения данного правового феномена. Цель: проведение общетеоретического исследования сложившихся в юридической науке позиций относительно определения законного интереса, а также формулирование на их основе собственного видения законных интересов, выявление признаков и особенностей, характерных для них. Методологическая основа: представлена диалектическим, сравнительно-правовым, формальноюридическим методами и логическим приемом анализа, которые дали возможность сопоставить имеющиеся позиции относительно определения и содержания законных интересов, а также выработать собственное видение данного правового явления. Результаты: аргументирована авторская позиция относительно представления законного интереса как самостоятельного персонифицированного объекта правовой защиты, а также выявлены основные признаки законного интереса, подтверждающие заявленное определение. Выводы: законный интерес в правовой системе Российского государства представлен в виде самостоятельного персонифицированного объекта правовой защиты, выраженного в правовой дозволенности совершать определенные действия, направленные на достижение необходимого результата.
MOESM1 of 2-Hydroxy-4-(3â ˛-oxo-3â ˛H-benzofuran-2â ˛-yliden)but-2-enoic acid biosynthesis from dibenzofuran using lateral dioxygenation in a Pseudomonas putida strain B6-2 (DSM 28064)
Creators: name: Liu, Xin
name: Wang, Weiwei
name: Hu, Haiyang
name: Lu, Xinyu
name: Zhang, Lige
name: Xu, Ping
name: Tang, Hongzhi
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1. Supplemrntary figures and table.
Analyses
Creators: name: Searston, Rachel A.
name: Byard, Graham
name: Hayes, Robert
name: Edmond, Gary
name: Raymond, Jennifer
name: Thompson, Matthew B
name: Eva, Kevin
name: Robson, Samuel G.
name: Osborn, Scott
name: Corbett, Brooklyn
name: Tangen, Jason M
name: Linzi Wilson-Wilde
name: McCarthy, Duncan
Publisher: name: OSF Registries
Year: 2019
Subjects: Fingerprint Examination
Forensic Decision-Making
Forensic Science
Perceptual Expertise
Visual Cognition

description: This component includes our complete data analytic pipeline: from raw individual .txt files to final R Markdown plots and analyses. The "analysis folder" contains data files (.txt) for 12 simulated novice participants and 12 simulated expert participants with pseudorandomly generated response data—these are used to test out the experimental analysis script, and model the null (e.g., what we'd expect to see in our data due to chance; see the simdata.jpeg plots as illustration). Also included is a LiveCode data extraction tool for aggregating raw data from the individual .txt files, an R Markdown folder with source code, and a fully documented html file documenting all code, notes, plots and results of statistical analyses. A 'final analysis' folder will be uploaded here once data collection is completed and the genuine human has data been thread through the data analytic pipeline.
К ВОПРОСУ О ПРОФЕССИОНАЛЬНОЙ ПРАВОВОЙ КУЛЬТУРЕ НА ПРИМЕРЕ ВОЕННОСЛУЖАЩИХ ФЕДЕРАЛЬНОЙ СЛУЖБЫ ВОЙСК НАЦИОНАЛЬНОЙ ГВАРДИИ РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Яковлев Михаил Валерьевич
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: правовая культура
правосознание
профессиональная правовая культура
механизм формирования профессиональной правовой культуры

description: Введение: исключительность возложенных на войска задач по обеспечению государственной и общественной безопасности, охране прав и свобод человека и гражданина, что предполагает непосредственную включенность военнослужащих в социальное пространство, определяет актуальность исследования данной тематики. Росгвардия — самостоятельное мощное военизированное формирование, предназначенное прежде всего для обеспечения внутренней безопасности государства, общественной безопасности, защиты прав и свобод человека и гражданина от противоправных посягательств. Указанная специфика возложенных обязанностей и тесный, как правило, контакт с населением выводят вопрос о профессиональной правовой культуре военнослужащих Росгвардии на уровень особой актуальности. Цель: формирование авторского понимания природы и специфики профессиональной правовой культуры военнослужащих Росгвардии. Методологическая основа: основным методом исследования является формально-юридический. В дополнение к нему применяются системно-структурный и деятельностный подходы. Результаты: предложено авторское понимание природы и специфики профессиональной правовой культуры военнослужащих Росгвардии, а также выделяются основные условия и средства ее повышения. Выводы: в исследовании проблем профессиональной правовой культуры военнослужащих Росгвардии представляется необходимым обращение к понятийной конструкции «механизм формирования профессиональной правовой культуры». Профессиональная правовая культура военнослужащих войск Росгвардии формируется комплексно на установочно-идеологическом, целевом, потребностно-мотивационном, познавательно-воспитательном уровнях. Под профессиональной правовой культурой военнослужащих войск Росгвардии предлагается понимать их внутреннее отношение к праву и правовым ценностям, выражающееся в качественных формализованных знаниях законодательства, в понимании целей и средств механизма правового регулирования, заключающихся в оперативном и качественном исполнении предметнофактической служебной деятельности, в безупречном выполнении воинских обязанностей, достижении поставленных служебных задач, а в материальном аспекте — в правовых актах, регламентирующих несение службы, исторических памятниках военного дела, музейных экспонатах, архивных документах, печатных изданиях и др.
An exploration of personal values as antecedent of gift-giving behaviour
Creators: name: Lekkumporn, Peeraya
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Gift-Giving Behaviour (GGB) has received significant attention from academic researchers in the past decade. Gift-giving is a unique behaviour. When people select a gift, they incorporate a range of specific personal values related to the nature of the occasion and the relationship between giver and recipient. However, to date, very few academic studies have explored such behaviour in depth. Consequently, this study aims to develop and validate the construct of GGB. Specifically, this study focuses on GGB in the context of selecting an intangible gift –choosing a restaurant – to host dinner for a close friend or family member. Furthermore, this study aims to explore the extent to which personal value influences GGB. Drawing from the extensive literature on GGB and the Theory of Planned Behaviour, this study proposed nine dimensions of GGB: attitude toward behaviour, subjective norm, perceived behavioural control, anticipate emotion, self-identity, intensity of intention, motivation of GGB, information searching, and gift-selection effort. Through exploratory and confirmatory factor analysis, it was found that the GGB construct actually consisted of eight dimensions: attitude toward behaviour, subjective norm, perceived behavioural control, anticipate emotion, self-identity toward others, self-identity toward self, purchase-decision involvement, and symbolic of gift. Structural Equation Modelling was then utilised to test the relationship between personal values and GGB constructs. The finding confirmed that certain personal values determine particular dimensions of GGB. For example, people who hold excitement value as their main value tend to actively engage in GGB because they tend to consider more dimensions when performing GGB which is opposite to people who hold sense of accomplishment. This study contributes to theoretical and managerial perspectives on the selection and giving of gifts. The theoretical contribution of developing a multi-dimensional GGB construct assists researchers to better understand this behaviour. In addition, the findings from analysis of the complex relationships between personal values and GGB confirmed and extended the findings of previous studies. From a managerial perspective, this study provides the knowledge base to develop better marketing plans for gift products or services, including utilising personal values as a tool to segment their target market.
Effects of glycyrrhizic acid on peroxisome proliferator-activated receptor γ, lipoprotein lipase and 11β-hydroxysteroid dehydrogenase in rats
Creators: name: Chia, Yoke Yin
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The metabolic syndrome is a cluster of metabolic abnormalities comprising of dyslipidaemia and insulin resistance (IR). Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor with a pivotal role in adipocyte differentiation and insulin sensitization. Studies on the ligand binding potential of glycyrrhizic acid (GA), a potential agonist to PPARγ displayed encouraging results in the amelioration of metabolic syndrome. Two isoforms of 11β-hydroxysteroid dehydrogenases, namely 11β-HSD1 and 11β-HSD2, regulate intracellular glucocorticoid levels. Lipoprotein lipase (LPL), a regulator of lipoprotein metabolism, is a downstream gene of PPARγ and its expression is reduced with the occurrence of IR and increased activities of 11β-HSD. The effects of two different routes of GA administration (oral vs. intraperitoneal), different dosages of GA and treatment periods were studied in rats. It was found that oral administration of 100 mg/kg GA led to optimum improvements in all the studied parameters. GA treatment led to an overall significant decrease in blood glucose and HOMA-IR (P < 0.05) as well as serum insulin levels (P > 0.05) and improvements in the lipid profile with a decrease in serum TAG, total cholesterol and LDL-cholesterol accompanied by an increase in HDL-cholesterol (P > 0.05). Expression levels of total PPARγ, PPARγ1, PPARγ2 and LPL as well as 11β-HSD1 and 2 activities were measured in six different tissues, i.e., the subcutaneous and visceral adipose tissues, abdominal muscle, quadriceps femoris, liver and kidney. Oral administration of 100 mg/kg GA led to significant increases in the expression levels of total PPARγ, PPARγ1, PPARγ2 and LPL in the subcutaneous and visceral adipose tissues, abdominal muscle and quadriceps femoris (P < 0.05) while non-significant increases (i.e., P > 0.05) were observed in the liver and kidney. The increase in tissue LPL expression correlated with the improvement of lipid profile in the GA-administered rats. GA administration also led to significant decreases (P < 0.05) in 11β-HSD1 activity in all the studied tissues except for the subcutaneous adipose tissue while 11β-HSD2 activity was significantly decreased in all the six tissues examined (P < 0.05). Overall, this study has shown that GA can possibly be used to ameliorate metabolic syndrome and demonstrated the interlinking roles of PPARγ, 11β-HSD and LPL in glucose homeostasis and lipid metabolism.
Pharmacological profiling of G protein-coupled receptors using Saccharomyces cerevisiae
Creators: name: Stewart, Gregory David
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: It is commonly accepted that the nature of drug efficacy is not a linear concept, but rather a multi-dimensional signalling event. This gives rise to the potential for ligands to be functionally selective, which is preferential activation of a set of signalling cascades at the exclusion of others. This idea poses certain problems and provides new approaches for drug discovery programs with regard to choice of assay format and generation of pathway-selective compounds, respectively. In light of this, the majority of drug discovery programs that search for functionally selective ligands, combat this issue by using multiple endpoint assays, which vary depending on the targeted pathway. However, this approach is sometimes difficult to interpret for a number of reasons, such as the fact that many pathways are mediated by more than one upstream effector, the experimental conditions may vary between assay formats, for example, buffer composition and kinetics of activation. Moreover, using many functional endpoints is often expensive and inefficient. In this vein, this thesis discusses the development of a novel approach to screening for functional selective ligands, using a Saccharomyces cerevisiae expression system, which has been hitherto overlooked for this purpose. The ability of this system to detect functional selectivity of ligands within a Gα protein family (Gαi/o), and across multiple Gα proteins (Gαq, Gαi1/2, Gα12), was assessed. There was evidence that both orthosteric and allosteric ligands that bind M3 muscarinic acetylcholine receptors display functional selectivity, which was predicted using the yeast system; whilst the capability of the yeast system to predict selectivity between Gαi/o subunits was comparatively reduced. In addition, the capacity of the yeast system to predict ligand parameters such as affinity and efficacy was also investigated. It was found that from data obtained in yeast, accurate affinity estimates could be generated. Furthermore, a potential use for yeast in estimating conformation-specific affinity values for agonists was revealed. Taken together, the evidence in this thesis suggests that the yeast signalling assays is a valuable and tractable platform for detecting pharmacological characteristics of existing and novel ligands.
Additional file 1: of Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca2+ and activating the FAK/Rho GTPases signaling pathways in vitro
Creators: name: Zhang, Yingchi
name: Yan, Jiyuan
name: Xu, Haoran
name: Yang, Yong
name: Li, Wenkai
name: Wu, Hua
name: Liu, Chaoxu
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Human MSC culture and stimulation. (DOCX 4878Â kb)
Data
Creators: name: Linzi Wilson-Wilde
name: Searston, Rachel A.
name: Corbett, Brooklyn
name: Thompson, Matthew B
name: Osborn, Scott
name: Hayes, Robert
name: Robson, Samuel G.
name: Edmond, Gary
name: McCarthy, Duncan
name: Raymond, Jennifer
name: Tangen, Jason M
name: Byard, Graham
name: Eva, Kevin
Publisher: name: OSF Registries
Year: 2019
Subjects: Fingerprint Examination
Forensic Decision-Making
Forensic Science
Perceptual Expertise
Visual Cognition

description: This component contains the raw individual .txt files outputted and time stamped on completing the experiment.
Additional file 1: of GoActive: a protocol for the mixedÂ methods process evaluation of a school-based physical activity promotion programme for 13â 14year old adolescents
Creators: name: Jong, Stephanie
name: Brown, Helen
name: Croxson, Caroline
name: Wilkinson, Paul
name: Corder, Kirsten
name: van Sluijs, Esther
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SPIRIT check list. (DOC 145Â kb)
Development of neural tissue engineering scaffolds for guided neurite extension within the central nervous system
Creators: name: Nisbet, David Russell
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis reports on the development of two unique neural tissue engineering scaffolds for cellular support and guided neurite extension within the central nervous system (CNS). For this reason this work is presented in 3 Parts to allow for a thorough understanding to be obtained, in regard to the development and characterisation of each unique neural tissue engineering scaffold; Part I focuses on the development of nanoscale polymer fibres produced using electrospinning; Part II is concerned with the examination of smart xyloglucan hydrogels, which are injected into the body as a liquid and then assemble forming a hydrogel scaffold when the temperature is raised to 37 ºC. Part III contains the final chapter and links the preceding Parts so that ultimately the benefits of each can be incorporated into a 'composite' scaffold. Such a scaffold may generate individual cellular niche environments that are more permissible for cell differentiation and maintenance or for directed axonal regeneration through mimicking some of the neurochemical and neuroanatomical architecture of physiological tissue.
Awards: Winner of the Mollie Holman Doctoral Medal for Excellence, Faculty of Engineering, 2009.
Altruism in teaching : towards a critical ontoloty of altruism
Creators: name: Pollard, Vikki Ann
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Abstract Telling stories is integral to knowing the world and the constitution of a sense of self. Feminist film and cultural theorist Teresa de Lauretis (1984) reminds us that story telling ‘is the process by which, for all social beings, subjectivity is constructed’ (159). We make who we are by telling stories. Taking this as a guiding principle this thesis examines the possibility of developing a subversive style of story-telling in order to tell different stories about teaching (McWilliam, 1994, St. Pierre, 1997). A common story of teaching is used as a focus - the story of the altruistic teacher. I argue that stories about altruism as they occur in popular culture and in educational research tend to valourise altruism. This neglects the limits that the virtue of altruism places upon the possibilities for subjectivities. Using the work of Nietzsche and Foucault, this thesis attempts to position altruism as central to a genealogy that seeks to investigate the limits of altruism and strives towards the possibility of telling different stories of altruism. Reflective practice as a method of inquiry into teaching practices is taken as a case study for the possible implementation of this style of story-telling. In order to achieve a subversive and reflective practice, reflective writing is reconceived as a grotesque realm in which surprise prompts reflection. The main contribution of this thesis is the development of a playfully subversive form of reflective writing that draws from the work of Bakhtin (1981, 1984) and from critical reflective writing (Pillow, 2003, Bleakley, 2000) to generate different stories of altruism in teaching.
Additional file 2: of GoActive: a protocol for the mixedÂ methods process evaluation of a school-based physical activity promotion programme for 13â 14year old adolescents
Creators: name: Jong, Stephanie
name: Brown, Helen
name: Croxson, Caroline
name: Wilkinson, Paul
name: Corder, Kirsten
name: van Sluijs, Esther
Publisher: name: figshare
Year: 2018
Subjects: Biological Sciences not elsewhere classified
Computational Biology

description: Focus group interview guide (mentors). (DOCX 18Â kb)
Additional file 1 of Let’s talk about work: pilot study of an education program on discussing work participation with cancer patients for general practitioners in training
Creators: name: de Wit, Mariska
name: van Asselt, Kristel M.
name: Mak-van der Vossen, Marianne
name: de Boer, Angela G.E.M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Additional file 1 of gcplyr: an R package for microbial growth curve data analysis
Creators: name: Blazanin, Michael
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: Supplementary Material 1.
An investigation into polyglutamine aggregation mechanisms
Creators: name: Robertson, Amy Louise
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Protein aggregation is a key mechanism involved in neurodegeneration associated with Alzheimer’s, Parkinson’s and Huntington’s diseases. Nine diseases (including Huntington’s) arise from polyglutamine (polyQ) expansion above a repeat threshold of approximately 37 glutamines, and neuronal toxicity correlates with the process of protein aggregation. The similar toxic gain-of-function mechanism of the nine diseases supports the hypothesis that disease onset and progression is dependent upon polyQ expansion. However, there is an increasing body of literature demonstrating that the protein context of the polyQ tract plays an important modulating role in the disease process. The composition of regions flanking repeats can alter the biochemical and biophysical properties of the polyQ region. Interactions between flanking regions and other molecules can also influence aggregation and cellular localization, which are critical factors for toxicity. More recently, there is evidence that domains flanking the polyQ tract can also aggregate independently of the polyQ tract, and that this significantly alters the rate at which the polyQ regions form fibrillar aggregates and the properties of these aggregates. This thesis investigates the molecular mechanisms leading to polyQ aggregation and the role of protein context in modulating the aggregation pathway. A family of model polyQ proteins were engineered and produced. The proteins have a repeat-length dependent aggregation mechanism, recapitulating the relationship between repeat length and age of disease onset. The stability and structure of the flanking domain were unperturbed when fused to a pathological length polyQ tract, suggesting that protein misfolding within the polyQ tract is the driving force behind the key characteristics of the polyQ diseases. The repeat location and domain architecture affect the rate of polyQ-dependent aggregation, indicating that host protein factors can modulate aggregation. Furthermore, the small heat shock protein, αB-crystallin does not inhibit the aggregation of the model polyQ protein that aggregates by the polyQ-driven mechanism. αB-crystallin does, however, inhibit aggregation of the disease protein ataxin-3 by a mechanism involving interactions with the flanking domain. Together, the results within this thesis have provided insight into the molecular basis of polyQ disease and have shown that the propensity for polyQ aggregation is determined by a complex interplay between the polyQ region, host protein factors and the cellular environment.
МЕЖДУНАРОДНО-ПРАВОВЫЕ СТАНДАРТЫ РЕГУЛИРОВАНИЯ ПРАВОВОГО СТАТУСА НЕПРАВИТЕЛЬСТВЕННЫХ ОРГАНИЗАЦИЙ И КОНСТИТУЦИОННО-ПРАВОВЫЕ ПРОБЛЕМЫ ИХ РЕАЛИЗАЦИИ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Хижняк Вероника Сергеевна
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: международное право
конституционное право России
международно-правовые стандарты
правовой статус
неправительственные организации
международные обязательства государств
права человека.

description: Введение: неправительственные организации (далее — НПО) являются институтами гражданского общества, деятельность которых необходима для реализации демократических принципов, создания условий для полноценного развития личности. Вопрос о правовом статусе этих образований является актуальным для науки как международного, так и для науки конституционного права. При этом международноправовое регулирование этого статуса оказывает влияние и на его конституционноправовое регулирование. Цель: на основе анализа международных документов выявить существующие в настоящее время международные стандарты регулирования правового статуса международных организаций, их содержание и особенности их применения в Российской Федерации. Методологическая основа: диалектический метод научного познания, системный, формально-юридический, сравнительно-правовой методы исследования. Результаты: на основе анализа международно-правовых документов было выявлено содержание международно-правовых стандартов в рассматриваемой сфере, а на основе анализа российского законодательства и правоприменительной практики освещены проблемы реализации международно-правовых стандартов в рассматриваемой сфере и предложены пути их решения. Выводы: в современном международном праве существуют довольно четкие международно-правовые стандарты правового статуса неправительственных организаций. В Российской Федерации существует ряд проблем, связанных с реализацией этих стандартов на ее территории.
КОНСТИТУЦИОННАЯ ОБЯЗАННОСТЬ ЗАБОТИТЬСЯ О РОДИТЕЛЯХ В СТРАНАХ ЕВРОПЫ, АЗИИ И РОССИИ: СРАВНИТЕЛЬНЫЙ АНАЛИЗ
Creators: name: Отставнова Елена Александровна
Publisher: name: Вестник Саратовской государственной юридической академии
Year: 2020
Subjects: родители
нетрудоспособные родители
конституционная обязанность
забота о родителях
Азия
Европа
Россия
традиции
религия
права человека.

description: Введение: в статье рассмотрены конституционно-правовые и моральнонравственные основы заботы трудоспособных детей о нетрудоспособных родителях в странах Европы, Азии и России. Анализируются Конституции и законодательство зарубежных государств и Российской Федерации в данной сфере общественных отношений. Цель: выявить истоки обязанности заботиться о родителях в странах с различными политическими режимами, установить виды факторов, влияющих на данный процесс; определить, какие из них оказывают наибольшее влияние на исполнение данной конституционной обязанности в России. Методологическая основа: выводы опираются на данные социологических и научных исследований, проводимых социологами, юристами, культурологами с применением диалектического, сравнительного и системного методов исследования. Результаты: аргументирована авторская позиция относительно факторов, влияющих на формирование и исполнение конституционной обязанности трудоспособных детей заботиться о нетрудоспособных родителях в странах с различными формами правления и политическими режимами, установлены правовые и нравственные основы исполнения данной обязанности в России. Выводы: в статье показано, что решение данного вопроса напрямую зависит от состояния института семьи в государстве. На данный момент в странах Европы интересы отдельного человека превалируют над интересами общества, в них происходит разрушение традиционной семьи, ее ценностей, что ведет к разрыву семейных связей, и связи поколений. В этих странах забота о нетрудоспособных родителях ложится в основном, на государство. В странах Азии на институт семьи значительное влияние оказывают традиции и религия, что ведет к сохранению традиционных семейных ценностей и преобладанию ответственности за достойную жизнь родителей детей. Россия как многонациональное государство, сочетает в себе некоторые западные ценности с традиционными и религиозными. Забота о нетрудоспособных родителях в России зависит от конфессиональной или национальной принадлежности человека.