cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 19: Figure S7. of Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1
Creators: name: Adjalley, Sophie
name: Scanfeld, Daniel
name: Kozlowski, Elyse
name: Llinás, Manuel
name: Fidock, David
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Gene sets with significant enrichment (orange) or depletion (blue) in 7G8 in comparison to 7G8 pfcrt_CTL for three windows of the parasite IDC corresponding to rings (R, 12–16 h post-invasion), trophozoites (T, 24–28 h post-invasion) and schizonts (S, 32–36 h post-invasion). (PDF 110 kb)
Additional file 2: of Process evaluation for complex interventions in health services research: analysing context, text trajectories and disruptions
Creators: name: Murdoch, Jamie
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Patient interview guide. Description of data: Topic guide for interviews with patients participating in ESTEEM process evaluation (DOC 295 kb)
Additional file 3: Figure S2. of Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1
Creators: name: Adjalley, Sophie
name: Scanfeld, Daniel
name: Kozlowski, Elyse
name: LlinĂĄs, Manuel
name: Fidock, David
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: Heatmaps showing alignment of each profiled transcriptome to that of 3D7. FFT was used to impute expression levels from the 8 sampled time points across a data set of 384 time points spanning the 48-hour IDC. This allowed expression level to be extrapolated with close temporal resolution (7.5Â min) across the IDC. Dynamic time warping was used to align all 384 points to those of the published 3D7 time series [48, 70], using the PCC score computed between each pair of points. (PDF 2732 kb)
C2F-SemiCD: A Coarse-to-Fine Semi-Supervised Change Detection Method Based on Consistency Regularization in High-Resolution Remote Sensing Images
Creators: name: Han, Chengxi
name: Wu, Chen
name: Hu, Meiqi
name: Li, Jiepan
name: Chen, Hongruixuan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: A high-precision feature extraction model is crucial for change detection (CD). In the past, many deep learning-based supervised CD methods learned to recognize change feature patterns from a large number of labelled bi-temporal images, whereas labelling bi-temporal remote sensing images is very expensive and often time-consuming; therefore, we propose a coarse-to-fine semi-supervised CD method based on consistency regularization (C2F-SemiCD), which includes a coarse-to-fine CD network with a multiscale attention mechanism (C2FNet) and a semi-supervised update method. Among them, the C2FNet network gradually completes the extraction of change features from coarse-grained to fine-grained through multiscale feature fusion, channel attention mechanism, spatial attention mechanism, global context module, feature refine module, initial aggregation module, and final aggregation module. The semi-supervised update method uses the mean teacher method. The parameters of the student model are updated to the parameters of the teacher Model by using the exponential moving average (EMA) method. Through extensive experiments on three datasets and meticulous ablation studies, including crossover experiments across datasets, we verify the significant effectiveness and efficiency of the proposed C2F-SemiCD method. The code will be open at: https://github.com/ChengxiHAN/C2F-SemiCDand-C2FNet.
Euparixia mexicana Gordon & McCleve 2003
Creators: name: Minor, Pablo
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Euparixia
Euparixia mexicana

description: 195 Euparixia mexicana Gordon & McCleve, 2003 [E]
Distribution: Mexico (Colima, Jalisco, Nayarit, Sinaloa, Sonora).
description: Published as part of Minor, Pablo, 2017, New state records and updated checklist of Aphodiini and Eupariini (Coleoptera: Scarabaeidae: Aphodiinae) from Mexico, pp. 493-514 in Zootaxa 4244 (4) on page 511, DOI: 10.11646/zootaxa.4244.4.3, http://zenodo.org/record/437241
Additional file 1: of Process evaluation for complex interventions in health services research: analysing context, text trajectories and disruptions
Creators: name: Murdoch, Jamie
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Staff interview guide. Description of data: Topic guide for interviews with staff participating in ESTEEM process evaluation (DOC 31 kb)
Hypogastrura martiani Skarzynski
Creators: name: Kahrarian, Morteza
name: Vafaei-Shoushtari, Reza
name: Skarżyński, Dariusz
name: Konikiewicz, Marta
name: Soleymannezhadyan, Ebrahim
name: Mehr, Masoumeh Shayan
name: Shams, Bahman
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Hypogastruridae
Hypogastrura
Hypogastrura martiani

description: Hypogastrura martiani Skarżyński & Kaprus’, 2009
? H. tullbergi: Cox 1982: 41
Material examined. 13 females, 5 males, soil and litter, Zagros Mountains, walnut orchard near Aziz abad village (N34°31’ E47°59’ / 1500 m a.s.l.), Kangavar County, Kermanshah Province, Iran, 6.xii.2012, leg. M. Kahrarian; 3 females, 2 males, litter and soil, oak forest, Zagros Mountains, southern slope of the Koor Koor mountain, near Chahar zebar-e-oliya village (N34°13’ E46°40’ /1600 a.s.l.), Kermanshah County, Kermanshah Province, Iran, 16.i.2013, leg. M. Kahrarian; 3 females, 2 males, soil and litter, Zagros Mountains, walnut and plum orchard near Safi abad village (N34°47’ E46°31’ / 898 m a.s.l.), Javanrud County, Kermanshah Province, 20.xii.2012, leg. M. Kahrarian.
Note. H. martiani, a member of the viatica group, was recently described from Southern Ukraine (Skarżyński & Kaprus’ 2009) and until now it was known only from Crimea coast. Cox (1982) mentioned a related species H. tullbergi from Iran, but in the light of Najt et al. (1984) revision, this record seems to be erroneous as the range of distribution of this species is restricted to the Arctic. Consequently record of H. tullbergi from Iran can be referred to H. martiani or some other species of the viatica group. Unfortunately we had no occasion to study specimens collected by Cox and its taxonomic status remains unclear.
description: Published as part of Kahrarian, Morteza, Vafaei-Shoushtari, Reza, Skarżyński, Dariusz, Konikiewicz, Marta, Soleymannezhadyan, Ebrahim, Mehr, Masoumeh Shayan & Shams, Bahman, 2013, A new species and new records of the genus Hypogastrura Bourlet, 1839 (Collembola, Hypogastruridae) from Iran, pp. 89-94 in Zootaxa 3709 (1) on page 93, DOI: 10.11646/zootaxa.3709.1.4, http://zenodo.org/record/284652
Co-evolution of dust grains and protoplanetary disks II: structure and evolution of protoplanetary disks; an analytical approach
Creators: name: Tsukamoto, Yusuke
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In our previous study (Tsukamoto {\it et al.} 2023), we investigated formation and early evolution of protoplanetary disks with 3D non-ideal magnetohydrodynamics simulations considering dust growth, and found that the modified equations of the conventional steady accretion disk model which consider the magnetic braking, { dust growth} and ambipolar diffusion reproduce the disk structure obtained from simulations very well. In this paper, as a sequel of the our previous study, we analytically investigate the structure and evolution of protoplanetary disks corresponding to Class 0/I young stellar objects using the modified steady accretion disk model combining an analytical model of envelope accretion. We estimate that the disk radius is several AU at disk formation epoch and increases to several 100 AU at the end of the accretion phase. The disk mass is estimated to be $0.01 M_\odot \lesssim M_{\rm disk} \lesssim 0.1 M_\odot$ for a disk with radius of several 10 AU and mass accretion rate of $\dot{M}_{\rm disk} \sim 10^{-6} M_\odot {\rm yr^{-1}}$. We also found that, with typical disk ionization rates and moderate mass accretion rate ($\dot{M}_{\rm disk}\gtrsim10^{-8} M_\odot {\rm yr^{-1}}$), magneto-rotational instability is suppressed in the disk because of low plasma $β$ and efficient ambipolar diffusion. We argue that the radial profile of specific angular momentum (or rotational velocity) at the disk outer edge should be continuously connected to that of the envelope if the disk evolves by magnetic braking, and should be discontinuous if the disk evolves by internal angular momentum transport process such as gravitational instability or magneto-rotational instability. Future detailed observations of the specific angular momentum profile around the disk outer edge are important for understanding the angular momentum transport mechanism of protoplanetary disks.
description: 14 pages,11 figures, accepted for publication in PASJ
Additional file 8: of Genome-wide replication landscape of Candida glabrata
Creators: name: StĂŠphane Descorps-DeclĂ¨Re
name: Saguez, Cyril
name: Cournac, Axel
name: Marbouty, Martial
name: Rolland, Thomas
name: Ma, Laurence
name: Bouchier, Christiane
name: Moszer, Ivan
name: Dujon, Bernard
name: Koszul, Romain
name: Guy-Franck Richard
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 60506 Virology

description: Colocalization scores calculated from a second C. glabrata 3C matrix [ 77 ] for each genetic element studied. Using this data set, in addition to early origins, a set of 275 ARSs colocalize. See Fig.Â 7 for legend. Note that in this experiment, cells were cross-linked for 30 min (instead of 10 min) with fresh formaldehyde (3 % final concentration). (PDF 35 kb)
Additional file 11: Figure S7. of Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms
Creators: name: Nirmalya Saha
name: Mengying Liu
name: Ambikai Gajan
name: Pile, Lori
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology

description: RT-qPCR validation of Class D genes (PDF 357Â kb)
Hypogastrura purpurescens Lubbock 1867
Creators: name: Kahrarian, Morteza
name: Vafaei-Shoushtari, Reza
name: Skarżyński, Dariusz
name: Konikiewicz, Marta
name: Soleymannezhadyan, Ebrahim
name: Mehr, Masoumeh Shayan
name: Shams, Bahman
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Hypogastruridae
Hypogastrura
Hypogastrura purpurescens

description: Hypogastrura purpurescens (Lubbock, 1867)
Material examined. 1 female, 1 male, soil and litter, Zagros Mountains, walnut orchard in Shahu city (N34°56’ E46°27’ / 1663 m a.s.l.), Paveh County, Kermanshah Province, Iran, 13. xii. 2012, leg. M. Kahrarian; 1 female, 1 male, soil, pasture on southern slope of the hill near Sia khor village (N 34°06′ E46°31′), Zagros Mountains, Islamabad-e Gharb County, Kermanshah Province, Iran, 15. ii. 2013, leg. M. Kahrarian; 1 female, 1 male, litter and soil, oak forest, Zagros Mountains, southern slope of the Koor Koor mountain, near Chahar zebar-e-oliya village (N34°13’ E46°40’ /1600 a.s.l.), Kermanshah County, Kermanshah Province, Iran, 0 4. xii. 2012, leg. M. Kahrarian; 2 males, the same data as above, but 0 9. iii. 2013.
Note. Though this species is common and widely distributed (Babenko et al. 1994, Thibaud et al. 2004) it is now recorded from Iran for the first time. Studied populations generally fits the description of H. purpurescens, but it exhibits ecomorphic characters described by Cassagnau (1955) (Figs 8-10) and this makes exact identification difficult.
description: Published as part of Kahrarian, Morteza, Vafaei-Shoushtari, Reza, Skarżyński, Dariusz, Konikiewicz, Marta, Soleymannezhadyan, Ebrahim, Mehr, Masoumeh Shayan & Shams, Bahman, 2013, A new species and new records of the genus Hypogastrura Bourlet, 1839 (Collembola, Hypogastruridae) from Iran, pp. 89-94 in Zootaxa 3709 (1) on page 93, DOI: 10.11646/zootaxa.3709.1.4, http://zenodo.org/record/284652
Additional file 3: Table S1. of Process evaluation for complex interventions in health services research: analysing context, text trajectories and disruptions
Creators: name: Murdoch, Jamie
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Analysing disruptions in the implementation of primary care telephone triage. Description of data: Multi-modal transcript, including use of screenshot images (DOC 290 kb)
Haroldiataenius hintoni Saylor 1933
Creators: name: Minor, Pablo
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Haroldiataenius
Haroldiataenius hintoni

description: 196 Haroldiataenius hintoni (Saylor, 1933)
Distribution: Mexico (Chiapas, Distrito Federal, Jalisco, Sonora, Tamaulipas); Guatemala; Honduras.
description: Published as part of Minor, Pablo, 2017, New state records and updated checklist of Aphodiini and Eupariini (Coleoptera: Scarabaeidae: Aphodiinae) from Mexico, pp. 493-514 in Zootaxa 4244 (4) on page 511, DOI: 10.11646/zootaxa.4244.4.3, http://zenodo.org/record/437241
Highly sensitive interleukin 6 detection by employing commercially ready liposomes in an LFA format
Creators: name: Rink, Simone
name: Kaiser, Barbara
name: Steiner, Mark-Steven
name: Duerkop, Axel
name: Baeumner, Antje J.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: LATERAL FLOW ASSAY; DEHYDRATION; DYE; Lateral flow assay; Point-of-care diagnostics; Bioanalysis; Fluorescence liposomes; Colloidal gold; Interleukin 6
subject: 540 Chemie

description: Recent years have confirmed the ubiquitous applicability of lateral flow assays (LFA) in point-of-care testing (POCT). To make this technology available for low abundance analytes, strategies towards lower limits of detections (LOD), while maintaining the LFA's ease of use, are still being sought. Here, we demonstrate how liposomes can significantly improve the LOD of traditional gold nanoparticle (AuNP)-based assays while fully supporting a ready-to-use system for commercial application. We fine-tuned liposomes towards photometric and fluorescence performance on the synthesis level and applied them in an established interleukin 6 (IL-6) immunoassay normally using commercial AuNP labels. IL-6's low abundance (< 10 pg mL(-1)) and increasing relevance as prognostic marker for infections make it an ideal model analyte. It was found that liposomes with a high encapsulant load (150 mmol L-1 sulforhodamine B (SRB)) easily outperform AuNPs in photometric LFAs. Specifically, liposomes with 350 nm in diameter yield a lower LOD even in complex matrices such as human serum below the clinically relevant range (7 pg mL(-1)) beating AuNP by over an order of magnitude (81 pg mL(-1)). When dehydrated on the strip, liposomes maintained their signal performance for over a year even when stored at ambient temperature and indicate extraordinary stability of up to 8 years when stored as liquid. Whereas no LOD improvement was obtained by exploiting the liposomes' fluorescence, an extraordinary gain in signal intensity was achieved upon lysis which is a promising feature for high-resolution and low-cost detection devices. Minimizing the procedural steps by inherently fluorescent liposomes, however, is not feasible. Finally, liposomes are ready for commercial applications as they are easy to mass-produce and can simply be substituted for the ubiquitously used AuNPs in the POCT market.
Additional file 7: of Genome-wide replication landscape of Candida glabrata
Creators: name: StĂŠphane Descorps-DeclĂ¨Re
name: Saguez, Cyril
name: Cournac, Axel
name: Marbouty, Martial
name: Rolland, Thomas
name: Ma, Laurence
name: Bouchier, Christiane
name: Moszer, Ivan
name: Dujon, Bernard
name: Koszul, Romain
name: Guy-Franck Richard
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Positions, coverages, and fitnesses of ARSs. (XLS 69 kb)
Hypogastrura socialis Uzel 1891
Creators: name: Kahrarian, Morteza
name: Vafaei-Shoushtari, Reza
name: Skarżyński, Dariusz
name: Konikiewicz, Marta
name: Soleymannezhadyan, Ebrahim
name: Mehr, Masoumeh Shayan
name: Shams, Bahman
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Hypogastruridae
Hypogastrura
Hypogastrura socialis

description: Hypogastrura socialis (Uzel, 1891)
Material examined. 3 females, 3 males, soil and litter, oak forest, Zagros Mountains, southern slope of the Koor Koor mountain, near Chahar zebar-e-oliya village (N34°13’ E46°40’ /1600 a.s.l.), Kermanshah County, Kermanshah Province, Iran, 4.xii.2012, leg. M. Kahrarian; 3 females, 5 males, the same data as above, but 16.i.2013.
Note. H. socialis is cyclomorphic, mass occuring and active on snow. The species is widely distributed in the Palaearctic (Babenko et al. 1994, Thibaud et al. 2004). Studied material comprised a winter form of the species with typically tooth-like granules and prominent apical swelling on the dens and large subapical tooth of the mucro (Fig. 7). This species has been recorded from Iran for the first time.
description: Published as part of Kahrarian, Morteza, Vafaei-Shoushtari, Reza, Skarżyński, Dariusz, Konikiewicz, Marta, Soleymannezhadyan, Ebrahim, Mehr, Masoumeh Shayan & Shams, Bahman, 2013, A new species and new records of the genus Hypogastrura Bourlet, 1839 (Collembola, Hypogastruridae) from Iran, pp. 89-94 in Zootaxa 3709 (1) on page 93, DOI: 10.11646/zootaxa.3709.1.4, http://zenodo.org/record/284652
Additional file 9: Figure S5. of Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1
Creators: name: Adjalley, Sophie
name: Scanfeld, Daniel
name: Kozlowski, Elyse
name: LlinĂĄs, Manuel
name: Fidock, David
Publisher: name: Figshare
Year: 2015
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Venn diagrams depicting the number of genes that were found differentially expressed between FCB and (A) FCB pfmdr1_3â ˛KD or (B) 7G8 pfcrt_CTL and 7G8 pfcrt_T76K during one or more developmental stages. Fold changes greater than 1.5 and normalized fold changes two standard deviations above the median value were used for the analyses. (PDF 82 kb)
Haroldiataenius limbatus Bates 1887
Creators: name: Minor, Pablo
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Haroldiataenius
Haroldiataenius limbatus

description: 197 Haroldiataenius limbatus (Bates, 1887)
Distribution: Mexico (Campeche, Chiapas, Hidalgo, Jalisco, Morelos, Nuevo León, Oaxaca, Puebla, Sinaloa, Sonora);
El Salvador; Guatemala; Honduras.
description: Published as part of Minor, Pablo, 2017, New state records and updated checklist of Aphodiini and Eupariini (Coleoptera: Scarabaeidae: Aphodiinae) from Mexico, pp. 493-514 in Zootaxa 4244 (4) on page 511, DOI: 10.11646/zootaxa.4244.4.3, http://zenodo.org/record/437241
Di ‐tert ‐butyldiphosphatetrahedrane as a Source of 1,2‐Diphosphacyclobutadiene Ligands
Creators: name: Hierlmeier, Gabriele
name: Coburger, Peter
name: Scott, Daniel J.
name: Maier, Thomas M.
name: Pelties, Stefan
name: Wolf, Robert
name: Pividori, Daniel M.
name: Meyer, Karsten
name: Leest, Nicolaas P.
name: de Bruin, Bas
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: POST TRANSITION-METALS; HETEROPOLYATOMIC ANIONS; PHOSPHAALKYNE COMPLEXES; INTERMETALLOID CLUSTERS; CRYSTAL-STRUCTURES; RING CONTRACTION; COVALENT RADII; BUILDING-BLOCK; ZINTL IONS; PHOSPHORUS; phosphatetrahedranes; phosphaalkyne oligomers; phosphorus; iron; cobalt
subject: 540 Chemie

description: Reactions of di-tert-butyldiphosphatetrahedrane (1) with cycloocta-1,5-diene- or anthracene-stabilised metalate anions of iron and cobalt consistently afford complexes of the rarely encountered 1,2-diphosphacyclobutadiene ligand, which have previously been very challenging synthetic targets. The subsequent reactivity of 1,2-diphosphacyclobutadiene cobaltates toward various electrophiles has also been investigated and is compared to reactions of related 1,3-diphosphacyclobutadiene complexes. The results highlight the distinct reactivity of such isomeric species, showing that the 1,2-isomers can act as precursors for previously unknown triphospholium ligands. The electronic structures of the new complexes were investigated by several methods, including NMR, EPR and Mossbauer spectroscopies as well as quantum chemical calculations.
Additional file 2: of Phylodynamic reconstruction of the spatiotemporal transmission and demographic history of coxsackievirus B2
Creators: name: Huang, Hui-Wen
name: Chen, Yao-Shen
name: Chen, Jeff
name: Po-Liang Lu
name: Yung-Cheng Lin
name: Chen, Bao-Chen
name: Li-Chiu Chou
name: Chu-Feng Wang
name: Su, Hui-Ju
name: Yi-Chien Huang
name: Yong-Ying Shi
name: Hsiu-Lin Chen
name: Bintou Sanno-Duanda
name: Tsi-Shu Huang
name: Kuei-Hsiang Lin
name: Tyan, Yu-Chang
name: Chu, Pei-Yu
Publisher: name: Figshare
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Global surveillance of coxsackievirus B2. (PDF 6 kb)
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3
Creators: name: Wachholz, Vanessa
name: Mustafa, Al-Hassan M.
name: Zeyn, Yanira
name: Henninger, Sven J.
name: Beyer, Mandy
name: Dzulko, Melanie
name: Piée-Staffa, Andrea
name: Brachetti, Christina
name: Haehnel, Patricia S.
name: Sellmer, Andreas
name: Mahboobi, Siavosh
name: Kindler, Thomas
name: Brenner, Walburgis
name: Nikolova, Teodora
name: Krämer, Oliver H.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: HISTONE DEACETYLASE INHIBITOR; ACUTE MYELOID-LEUKEMIA; ANTILEUKEMIC INTERACTIONS; RESISTANCE; CHK1; APOPTOSIS; TARGET; REPAIR; CYCLE; DIFFERENTIATION; AML; Drug interaction; FLT3-ITD; HDAC; HDACi; TKi
subject: 615 Pharmazie

description: Acute myeloid leukemia (AML) with mutations in the FMS-like tyrosine kinase (FLT3) is a clinically unresolved problem. AML cells frequently have a dysregulated expression and activity of epigenetic modulators of the histone deacetylase (HDAC) family. Therefore, we tested whether a combined inhibition of mutant FLT3 and class I HDACs is effective against AML cells. Low nanomolar doses of the FLT3 inhibitor (FLT3i) AC220 and an inhibition of class I HDACs with nanomolar concentrations of FK228 or micromolar doses of the HDAC3 specific agent RGFP966 synergistically induce apoptosis of AML cells that carry hyperactive FLT3 with an internal tandem duplication (FLT3-ITD). This does not occur in leukemic cells with wild-type FLT3 and without FLT3, suggesting a preferential toxicity of this combination against cells with mutant FLT3. Moreover, nanomolar doses of the new FLT3i marbotinib combine favorably with FK228 against leukemic cells with FLT3-ITD. The combinatorial treatments potentiated their suppressive effects on the tyrosine phosphorylation and stability of FLT3-ITD and its downstream signaling to the kinases ERK1/ERK2 and the inducible transcription factor STAT5. The beneficial pro-apoptotic effects of FLT3i and HDACi against leukemic cells with mutant FLT3 are associated with dose- and drug-dependent alterations of cell cycle distribution and DNA damage. This is linked to a modulation of the tumor-suppressive transcription factor p53 and its target cyclin-dependent kinase inhibitor p21. While HDACi induce p21, AC220 suppresses the expression of p53 and p21. Furthermore, we show that both FLT3-ITD and class I HDAC activity promote the expression of the checkpoint kinases CHK1 and WEE1, thymidylate synthase, and the DNA repair protein RAD51 in leukemic cells. A genetic depletion of HDAC3 attenuates the expression of such proteins. Thus, class I HDACs and hyperactive FLT3 appear to be valid targets in AML cells with mutant FLT3.
Additional file 1: of A randomized controlled trial of hospital versus home based therapy with oral amoxicillin for severe pneumonia in children aged 3 â   59Â months: The IndiaCLEN Severe Pneumonia Oral Therapy (ISPOT) Study
Creators: name: Patel, Archana
name: Bang, Akash
name: Singh, Meenu
name: Dhande, Leena
name: Chelliah, Luke
name: Malik, Ashraf
name: Khadse, Sandhya
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Standard operating procedures that were used to train the physicians in assessing clinical signs. (PDF 240Â kb)
Pentaphosphaferrocene-mediated synthesis of asymmetric organo-phosphines starting from white phosphorus
Creators: name: Reichl, Stephan
name: Mädl, Eric
name: Riedlberger, Felix
name: Piesch, Martin
name: Balázs, Gábor
name: Seidl, Michael
name: Scheer, Manfred
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: BOND COVALENT RADII; LIGANDS; CHEMISTRY; ROUTE
subject: 540 Chemie

description: The synthesis of phosphines is based on white phosphorus, which is usually converted to PCl3, to be afterwards substituted step by step in a non-atomic efficient manner. Herein, we describe an alternative efficient transition metal-mediated process to form asymmetrically substituted phosphines directly from white phosphorus (P-4). Thereby, P-4 is converted to [Cp*Fe(eta(5)-P-5)] (1) (Cp* = eta(5)-C-5(CH3)(5)) in which one of the phosphorus atoms is selectively functionalized to the 1,1-diorgano-substituted complex [Cp*Fe(eta(4)-P5R ' R '')] (3). In a subsequent step, the phosphine PR ' R '' R"' (R ' not equal R '' not equal R"' = alky, aryl) (4) is released by reacting it with a nucleophile R"'M (M = alkali metal) as racemates. The starting material 1 can be regenerated with P-4 and can be reused in multiple reaction cycles without isolation of the intermediates, and only the phosphine is distilled off. Asymmetrically substituted phosphine ligands play a decisive role in catalysis, but their synthesis is rather challenging and often involves hazardous chemicals such as PCl3 or PH3. Here, the authors report the one-pot preparation of asymmetric phosphines from white phosphorus via a pentaphosphaferrocene based modular system, in which the transition metal complex can be reused.
Additional file 1: of Seeking and sharing: why the pulmonary fibrosis community engages the web 2.0 environment
Creators: name: Albright, Karen
name: Walker, Tarik
name: Baird, Susan
name: Eres, Linda
name: Farnsworth, Tara
name: Fier, Kaitlin
name: Kervitsky, Dolly
name: Korn, Marjorie
name: Lederer, David
name: McCormick, Mark
name: Steiner, John
name: Vierzba, Thomas
name: Wamboldt, Frederick
name: Swigris, Jeffrey
Publisher: name: Figshare
Year: 2016
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology

description: Online Supplement. (DOCX 28Â kb)
Additional file 1: of Localization, quantification and interaction with host factors of endogenous HTLV-1 HBZ protein in infected cells and ATL
Creators: name: Goutham Raval
name: Bidoia, Carlo
name: Forlani, Greta
name: Tosi, Giovanna
name: Gessain, Antoine
name: Accolla, Roberto
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: Figure S1. Specificity of the 4D4 parental and its cloned 4D4-F3 hybridoma for HBZ molecule. Cell lysates of Cos cells transfected with myc-tagged HBZ (HBZmyc) or non transfectd (mock) were migrated on SDS-PAGE gels, blotted on nitrocellulose membranes and probed with supernatant from the 4D4 parental hybridoma or its cloned product 4D4-F3, raised against a GST-tagged HBZ protein. As negative control, the supernatant of the P3U1 myeloma cells used for somatic cell fusion was used.
Haroldiataenius semipilosus Van Dyke 1928
Creators: name: Minor, Pablo
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Haroldiataenius
Haroldiataenius semipilosus

description: 200 Haroldiataenius semipilosus (Van Dyke, 1928)
Distribution: Mexico (Sonora); United States of America.
description: Published as part of Minor, Pablo, 2017, New state records and updated checklist of Aphodiini and Eupariini (Coleoptera: Scarabaeidae: Aphodiinae) from Mexico, pp. 493-514 in Zootaxa 4244 (4) on page 511, DOI: 10.11646/zootaxa.4244.4.3, http://zenodo.org/record/437241
Siphonorhinus undetermined
Creators: name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Siphonophorida
Siphonorhinidae
Siphonorhinus
Siphonorhinus undetermined

description: Siphonorhinus sp.
Fig. 1
MATERIAL EXAMINED: MHNG Mad 89/21; 3 ♂, 2 ♀; Madagascar, Province Antananarivo, Ankaratra massif, Station Forestière Manjakatompo, près du sommet du Anosirivo, forêt primaire, prélèvement de sol dans une vieille souche, 1980 m; 26.xi.1989, leg. B. Hauser, extraction Berlese à Genève.
HABITAT: The forest of Manjakatompo is one of the three last (99% has been destroyed) indigenous high plateau forests on Madagascar. It was planted by humans a few centuries ago, when it was still connected to now no longer existing fragments of pristine highland vegetation. It harbours rare and endemic genera and species of mammals, but lacks other faunal elements (such as lemurs) most likely due to the artificial origin of the forest and the lack of any fruit-bearing trees (Goodman et al., 1996).
REMARKS: Largest specimen (male) about 11 mm long, 0.7 mm wide, with 61+1 segments. Colouration whitish orange (Fig. 1A). Only specimens of this species could be studied in more detail. While the author refrains from a formal description, the illustrated characters can be compared with those of properly revised species (Shelley & Hoffman, 2004; Marek et al., 2012) to allow a revision of the family in the future. This species is only tentatively placed in the genus Siphonorhinus Pocock, 1894, whose eight species occur in Indonesia, Vietnam, Cambodia, Laos and India (Jeekel, 2001). Siphonorhinus is characterized by an unmodified first leg in males where the coxa is fused to the sternite or stigmatic plate (Fig. 1B), by a pear-shaped head (Fig. 1C), and by the apical podomere of the posterior gonopod being divided into two branches lacking spines (Fig. 1D). In the South African genus Nematozonium Verhoeff, 1939 the posterior gonopods are different, with one of the branches wrapped around the second branch and with each of the branches carrying a spine (Shelley & Hoffman, 2004). The species of the other Asian genus, Kleruchus Attems, 1938 (originally assigned to the order Platydesmida), are much larger and wider, and feature thick modified first legs in males. The fourth genus, Illacme Cook & Loomis 1928, is known only from California, USA. It resembles the shorter species presented here, and features different, apically serrated posterior gonopods (compare Fig. 1D to Marek et al., 2012: fig. 6a).
description: Published as part of Wesener, Thomas, 2014, First records of the order Siphonophorida from Madagascar and Mauritius (Diplopoda), pp. 415-423 in Revue suisse de Zoologie 121 (3) on page 417, DOI: 10.5281/zenodo.5823062
Additional file 1: Table S1. of Association between markers of glycemia and carotid intima-media thickness: the MARK study
Creators: name: Gomez-Marcos, Manuel
name: Gomez-Sanchez, Leticia
name: Patino-Alonso, Maria
name: Recio-Rodriguez, Jose
name: Regalado, Natividad
name: Ramos, Rafel
name: Marti, Ruth
name: Agudo-Conde, Cristina
name: Rodriguez-Sanchez, Emiliano
name: Maderuelo-Fernandez, Jose
name: Garcia-Ortiz, Luis
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: Parameters of vascular structure by tertiles of markers of glycemia. (DOCX 17 kb)
Evaluating the efficacy of Connexin 43 mimetics Tonabersat and Peptide 5 in blocking inflammatory cytokine induced changes in markers of injury in human proximal tubule cells
Creators: name: Manton, Thomas
Publisher: name: University of Lincoln
Year: 2024
Subjects: C910 - Applied biological sciences

description: A thesis submitted in fulfilment of the examination requirements for the award of a Master of Science by Research in Biochemistry and Molecular Biology, awarded by the University of Lincoln, School of Life Sciences, January 2023, supervised by Prof. Claire Hills and Prof. Paul Squires.
Noncovalent CH‐π and π‐π Interactions in Phosphoramidite Palladium(II) Complexes with Strong Conformational Preference
Creators: name: Žabka, Matej
name: Naviri, Lavakumar
name: Gschwind, Ruth M.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: ENANTIOSELECTIVE CONJUGATE ADDITION; FACE AROMATIC INTERACTIONS; MONODENTATE PHOSPHORAMIDITE; MOLECULAR RECOGNITION; LONDON DISPERSION; LIGANDS; BALANCE; HYDROGENATION; FORCES; CHEMISTRY; conformational analysis; NMR spectroscopy; noncovalent interactions; phosphoramidites; supramolecular balance
subject: 540 Chemie

description: The weak noncovalent interactions and flexibility of ligands play a key role in enantioselective metal-catalyzed reactions. In transition metal complexes and their catalytic applications, the experimental assessment and the design of key interactions is as difficult as the prediction of the enantioselectivities, especially for flexible, privileged ligands such as chiral phosphoramidites. Therefore, the interligand interactions in cis-(PdL2Cl2)-L-II phosphoramidite complexes were investigated by NMR spectroscopy and computations. We were able to induce a strong conformational preference by breaking the symmetry of the C-2-symmetric side chain of one of the ligands, and shift the equilibrium between hetero- and homocomplexes towards heterocomplexes because of interligand interactions in the cis-complexes. The modulation of aryl substituents was exploited, along with the solvent effect. The combined CH-pi and pi-pi interactions reveal design patterns for binding and folding of chiral ligands and catalysts.
Additional file 1: of A simple method for identifying parameter correlations in partially observed linear dynamic models
Creators: name: Li, Pu
name: Vu, Quoc
Publisher: name: Figshare
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Derivation of the sensitivity matrix and solutions of the homogeneous linear equations in example 1, 2 and 4. This file contains detailed derivations and descriptions of the methods and associated results of the examples. (PDF 190 kb)
Siphonorhinidae Cook 1895
Creators: name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Siphonophorida
Siphonorhinidae

description: Siphonorhinidae Cook, 1895
The family Siphonorhinidae is characterized by a pyriform, subtriangular head that is not extended into a rostrum, devoid of macrosetae (Fig. 1C). Head with discernable mouthparts, especially mandibles (Attems, 1938). Antennae bent between antennomeres 3 and 4, pits of sensory cones on articles 5 and 6 absent, only a field of sensilla basiconica present (Fig. 1C). Containing 11 species grouped in four genera (Siphonorhinus, Illacme, Nematozonium and Kleruchus), distributed in California, South Africa and southeastern Asia (Jeekel, 2001).
MATERIAL EXAMINED: FMNH-INS 4000; 1 ♀, 1 immature; Madagascar, Province Fianarantsoa, R. S. Ivohibe, 8 km east of Ivohibe, camp II, 22.4833°S, 46.9683°E, 1200 m, montane rainforest; coll. B. L. Fisher, 15.-21.x.1997, Winkler extraction. Remarks: Colouration light brownish white. Body densely pilose with long setae. – FMNH-INS 8012; 1 ♀; Madagascar, Province Toliara, Réserve Naturelle Intégrale d’Andohahela, parcelle 1, 20.0 km SE Andranondambo, 24.5617°S, 46.7217°E, 1875 m, montane rainforest; coll. S. M. Goodman, 27.xi.-05.xii.1995. Remarks: Colouration whitish, densely pilose, with short setae. – FMNH-INS 8036; 1 immature; same data as for FMNH-INS 8012. Remarks: Probably same species as FMNH-INS 8012. – FMNH-INS 8068; 5 ♀; same data as for FMNH-INS 8012. Remarks: 1 ♀ with eggs. Probably same species as FMNH-INS 8012. – FMNH-INS 8125; 1 ♂; Madagascar, Province Fianarantsoa, 40 km S Ambalavao, Rés. Andringitra, 22.2167°S, 46.9667°E, montane rainforest; coll. B. L. Fisher, 15.x.1993, Winkler extraction. Remarks: Colouration brown, with patches of white. Densely pilose with short setae.
description: Published as part of Wesener, Thomas, 2014, First records of the order Siphonophorida from Madagascar and Mauritius (Diplopoda), pp. 415-423 in Revue suisse de Zoologie 121 (3) on pages 417-418, DOI: 10.5281/zenodo.5823062
Martinezia excavaticollis Blanchard 1847
Creators: name: Minor, Pablo
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Martinezia
Martinezia excavaticollis

description: 201 Martinezia excavaticollis (Blanchard, 1847)
Distribution: Mexico (Nayarit); Argentina; Bolivia; southeastern Brazil; Paraguay.
description: Published as part of Minor, Pablo, 2017, New state records and updated checklist of Aphodiini and Eupariini (Coleoptera: Scarabaeidae: Aphodiinae) from Mexico, pp. 493-514 in Zootaxa 4244 (4) on page 511, DOI: 10.11646/zootaxa.4244.4.3, http://zenodo.org/record/437241
Additional file 4: of Phylodynamic reconstruction of the spatiotemporal transmission and demographic history of coxsackievirus B2
Creators: name: Huang, Hui-Wen
name: Chen, Yao-Shen
name: Chen, Jeff
name: Po-Liang Lu
name: Yung-Cheng Lin
name: Chen, Bao-Chen
name: Li-Chiu Chou
name: Chu-Feng Wang
name: Su, Hui-Ju
name: Yi-Chien Huang
name: Yong-Ying Shi
name: Hsiu-Lin Chen
name: Bintou Sanno-Duanda
name: Tsi-Shu Huang
name: Kuei-Hsiang Lin
name: Tyan, Yu-Chang
name: Chu, Pei-Yu
Publisher: name: Figshare
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Models compared by an extension of air carrier investment model (ACIM). (PDF 10 kb)
Additional file 2: of A randomized controlled trial of hospital versus home based therapy with oral amoxicillin for severe pneumonia in children aged 3 â   59Â months: The IndiaCLEN Severe Pneumonia Oral Therapy (ISPOT) Study
Creators: name: Patel, Archana
name: Bang, Akash
name: Singh, Meenu
name: Dhande, Leena
name: Chelliah, Luke
name: Malik, Ashraf
name: Khadse, Sandhya
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Details of contributorship of the ISPOT study group. (PDF 288Â kb)
Siphonophoridae Newport 1844
Creators: name: Wesener, Thomas
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Siphonophorida
Siphonophoridae

description: Siphonophoridae Newport, 1844
Siphonophorida characterized by a head extended into a sharply acuminate ‘beak’ or rostrum, lower half of it formed by gnathochilarium. Head with four macrosetae. Antennae straight, not elbowed, antennomeres 5 and 6 with large, conspicuous pit containing numerous sensory cones (Hoffman, 1982). Antennomere 2 of normal length. 104 species in ten genera distributed in America, SE Asia and the Indian subcontinent (including N Pakistan), Australia and New Zealand (Jeekel, 2001).
MATERIAL EXAMINED: FMNH-INS 3978; 1 ♀; Madagascar, Province Antsiranana, R.S. Manongarivo, 20.4 km SW Antanambao, 14.0467°S, 48.4017°E, 1860 m, montane rainforest; coll. B. L. Fisher, 03.xi.1998, Winkler extraction. Remarks: Colouration marbled greyish, body short and densely pilose. – FMNH-INS 4089; 1 ♂; Madagascar, Province Antsiranana, Befingotra (9.2 km WSW), Rés. Anjanaharibe-Sud, 14.7500°S, 49.4667°E, 1280 m, montane rainforest; coll. B. L. Fisher, 05.xi.1994, Winkler extraction. Remarks: Colour similar to FMNH- INS 3978.
description: Published as part of Wesener, Thomas, 2014, First records of the order Siphonophorida from Madagascar and Mauritius (Diplopoda), pp. 415-423 in Revue suisse de Zoologie 121 (3) on page 418, DOI: 10.5281/zenodo.5823062
Additional file 1: of Evaluating the effectiveness of selected community-level interventions on key maternal, child health, and prevention of mother-to-child transmission of HIV outcomes in three countries (the ACCLAIM Project): a study protocol for a randomized controlled trial
Creators: name: Woelk, Godfrey
name: Kieffer, Mary
name: Damilola Walker
name: Mpofu, Daphne
name: Rhoderick Machekano
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 122 kb)
Martinezia vandykei Hinton 1936
Creators: name: Minor, Pablo
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Martinezia
Martinezia vandykei

description: 202 Martinezia vandykei (Hinton, 1936) [E]
description: Published as part of Minor, Pablo, 2017, New state records and updated checklist of Aphodiini and Eupariini (Coleoptera: Scarabaeidae: Aphodiinae) from Mexico, pp. 493-514 in Zootaxa 4244 (4) on page 512, DOI: 10.11646/zootaxa.4244.4.3, http://zenodo.org/record/437241
Photocatalytic Arylation of P4 and PH3: Reaction Development Through Mechanistic Insight
Creators: name: Rothfelder, Robin
name: Streitferdt, Verena
name: Lennert, Ulrich
name: Cammarata, Jose
name: Scott, Daniel J.
name: Zeitler, Kirsten
name: Gschwind, Ruth M.
name: Wolf, Robert
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: WHITE PHOSPHORUS; ACTIVATION; FUNCTIONALIZATION; DEPROTONATION; ROUTE; arylation; NMR spectroscopy; phosphine; photoredox catalysis; white phosphorus
subject: 540 Chemie

description: Detailed P-31{H-1} NMR spectroscopic investigations provide deeper insight into the complex, multi-step mechanisms involved in the recently reported photocatalytic arylation of white phosphorus (P-4). Specifically, these studies have identified a number of previously unrecognized side products, which arise from an unexpected non-innocent behavior of the commonly employed terminal reductant Et3N. The different rate of formation of these products explains discrepancies in the performance of the two most effective catalysts, [Ir(dtbbpy)(ppy)(2)][PF6] (dtbbpy=4,4 '-di-tert-butyl-2,2 '-bipyridine) and 3DPAFIPN. Inspired by the observation of PH3 as a minor intermediate, we have developed the first catalytic procedure for the arylation of this key industrial compound. Similar to P-4 arylation, this method affords valuable triarylphosphines or tetraarylphosphonium salts depending on the steric profile of the aryl substituents.