cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Double-Q spin-density wave in iron arsenide superconductors
Creators: name: Allred, J. M.
name: Taddei, K. M.
name: Bugaris, D. E.
name: Krogstad, M. J.
name: Lapidus, S. H.
name: Chung, D. Y.
name: Claus, H.
name: Kanatzidis, M. G.
name: Brown, D. E.
name: Kang, J.
name: Fernandes, R. M.
name: Eremin, I.
name: Rosenkranz, S.
name: Chmaissem, O.
name: Osborn, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Elucidating the nature of the magnetic ground state of iron-based superconductors is of paramount importance in unveiling the mechanism behind their high temperature superconductivity. Until recently, it was thought that superconductivity emerges only from an orthorhombic antiferromagnetic stripe phase, which can in principle be described in terms of either localized or itinerant spins. However, we recently reported that tetragonal symmetry is restored inside the magnetically ordered state of a hole-doped BaFe2As2. This observation was interpreted as indirect evidence of a new double-Q magnetic structure, but alternative models of orbital order could not be ruled out. Here, we present Mossbauer data that show unambiguously that half of the iron sites in this tetragonal phase are non-magnetic, establishing conclusively the existence of a novel magnetic ground state with a non-uniform magnetization that is inconsistent with localized spins. We show that this state is naturally explained as the interference between two spin-density waves, demonstrating the itinerant character of the magnetism of these materials and the primary role played by magnetic over orbital degrees of freedom.
description: 7 pages, 3 figures
High-resolution crinoid phyletic inter-relationships derived from molecular data
Creators: name: HEMERY, Lenaïg G.
name: ROUX, Michel
name: AMEZIANE, Nadia
name: ELEAUME, Marc
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Different approaches to the significance of morphological characters have led to alternative opinions on the phyletic affinities within the class Crinoidea. The molecular approach developed in this work represents a new, extensive, independent dataset that allows the testing of alternative crinoid inter-relationship hypotheses. We sampled 105 specimens from 25 of the 32 extant crinoid families, sequenced four genes (COI, 16S, 28S, 18S) amounting to 3848-bp of sequence data and conducted maximum likelihood and Bayesian analyses. In this comprehensive preliminary approach of phylo - genetic inter-relationships within the class Crinoidea, a clade A is composed of stalked crinoids exclusively and a clade B comprises all the comatulids plus a number of stalked crinoids (i.e. Bourgueticrinina). The clade A comprises the genera Holopus and Neogymnocrinus, representatives of the families Hyocrinidae and Pentacrinitidae (sensu lato), and the species Caledocrinus vaubani Avocat & Roux, 1990. The clade B comprises all other crinoids but only a portion of the families represented are found monophyletic. Similarly antedonid sub-families and some genera (e.g. Florometra and Antedon) are found para- or polyphyletic. Molecular data are congruent with the few interpretations based on detailed ontogenetic analyses, but also often reveal numerous para- or polyphyletic taxa. The hierarchy of morphological characters and taxa definition among crinoids need to be substantially revised.
Anomalous pseudogap in population imbalanced Fermi superfluids
Creators: name: Karmakar, Madhuparna
name: Majumdar, Pinaki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In a Fermi superfluid increasing population imbalance leads initially to reduction of the transition temperature, then the appearance of modulated Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) states, and finally the suppression of pairing itself. For interaction strength such that the `balanced' system has a normal state pseudogap, increasing imbalance reveals anomalous spectral behavior. At a fixed weak imbalance (small polarization) the stable homogeneous superfluid occurs only above a certain temperature. The density of states has a minimum at the Fermi level, then a weak peak {\it within the gap}, and then the large, gap edge, coherence features. On heating, this non monotonic energy dependence changes to a more conventional fluctuation driven pseudogap, with a monotonic energy dependence. At large imbalance the ground state is FFLO and `pseudogapped' due to the modulated order. It changes to a gapless normal state on heating, and then shows a pseudogap again at a higher temperature. These weak imbalance and strong imbalance features both involve effects well beyond mean field theory. We establish them by using a Monte Carlo technique on large lattices, motivate the results in terms of the pairing field distribution, and compare them to spectroscopic results in the imbalanced unitary Fermi gas.
description: 7 pages, 5 figures. This version supercedes 1508.00398
(3753) Mary Baxter Chesser
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Involvement of Egr-1/RelA Synergy in Distinguishing T Cell Activation from Tumor Necrosis Factor-α–induced NF-κB1 Transcription
Creators: name: Mayo, Marty W.
name: Baldwin Jr., Albert S.
name: Cogswell, Paticia C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: NF-κB is an important transcription factor required for T cell proliferation and other immunological functions. The NF-κB1 gene encodes a 105-kD protein that is the precursor of the p50 component of NF-κB. Previously, we and others have demonstrated that NF-κB regulates the NF-κB1 gene. In this manuscript we have investigated the molecular mechanisms by which T cell lines stimulated with phorbol 12-myristate 13-acetate (PMA) and phytohemagglutin (PHA) display significantly higher levels of NF-κB1 encoding transcripts than cells stimulated with tumor necrosis factor-α, despite the fact that both stimuli activate NF-κB. Characterization of the NF-κB1 promoter identified an Egr-1 site which was found to be essential for both the PMA/ PHA-mediated induction as well as the synergistic activation observed after the expression of the RelA subunit of NF-κB and Egr-1. Furthermore, Egr-1 induction was required for endogenous NF-κB1 gene expression, since PMA/PHA-stimulated T cell lines expressing antisense Egr-1 RNA were inhibited in their ability to upregulate NF-κB1 transcription. Our studies indicate that transcriptional synergy mediated by activation of both Egr-1 and NF-κB may have important ramifications in T cell development by upregulating NF-κB1 gene expression.
Überlegungen zur ikonotopischen Diskursivität lebenslangen Lernens
Creators: name: Dörner, Olaf
Publisher: name: bildungsforschung
Year: 2011

description: Ausgehend von einem bildhaften Diskurs lebenslangen Lernens soll hier die These vertreten werden, dass Bebilderungen lebenslangen Lernens eine diskursive Verortung von Bildern im Feld der Erwachsenen- und Weiterbildung darstellen. Erst über ihre Verwendung im Zusammenhang lebenslangen Lernens werden Bilder zu Bildern lebenslangen Lernen. Dem wird grundlegend vorangestellt, dass im Anschluss an eine ikonische Wendung (vgl. Böhm 1994) von sozialer Praxis als einer bildhaften auszugehen ist. Bilder stellen eine Möglichkeit dar, sich dieser Praxis zu vergewissern, etwa der Praxis derjenigen, die Bilder herstellen, auf ihnen abgebildet sind oder mit ihnen umgehen. Im folgenden Beitrag soll es um Fragen und Überlegungen zur Praxis einer diskursiven Verortung von Bildern im Feld der Erwachsenen- und Weiterbildung gehen. Dazu ist es notwendig, nicht nur die Bilder selbst, sondern auch ihre ikonotopische Dimension in den Blick zu nehmen. Die Berücksichtigung von Bild-Orten als Ausdruck sozialer Praxis eröffnet Möglichkeiten, erfahrungsgebundene Orientierungen verschiedener Akteure und Akteursgruppen als konstitutive Elemente einer ikonotopischen Diskursivität lebenslangen Lernens zu betrachten. Es folgen zunächst einige grundlagentheoretische Ausführungen zu Ikonotop als sinnkonstituierendes Element sozialer Praxis (1). Im Anschluss werden Bebilderungen lebenslangen Lernens als diskursive Verortung von Bildern im Feld Erwachsenenbildung näher bestimmt (2). Anhand empirischer Beispiele sollen Aspekte des bildhaften Umgangs mit lebenslangem Lernen in Weiterbildungskontexten skizziert werden. (3). Inwieweit von einer ikonotopischen Diskursivität lebenslangen Lernens die Rede sein kann, soll im Fazit resümiert werden (4).
description: bildungsforschung, Bd. 1 (2011): Bild, Bildung und Erziehung
Role of the 5-Lipoxygenase–activating Protein (FLAP) in Murine Acute Inflammatory Responses
Creators: name: Goulet, Jennifer L.
name: Griffiths, Richard J.
name: Byrum, Robert S.
name: Koller, Beverly H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Leukotrienes are potent inflammatory mediators synthesized from arachidonic acid (AA) predominately by cells of myeloid origin. The synthesis of these lipids is believed to be dependent not only on the expression of the enzyme 5-lipoxygenase (5-LO), which catalyzes the first steps in the synthesis of leukotrienes, but also on expression of a nuclear membrane protein termed the 5-LO–activating protein (FLAP). To study the relationship of these two proteins in mediating the production of leukotrienes in vivo and to determine whether the membrane protein FLAP has additional functions in various inflammatory processes, we have generated a mouse line deficient in this protein. FLAP-deficient mice develop normally and are healthy. However, an array of assays comparing inflammatory reactions in FLAP-deficient mice and in normal controls revealed that FLAP plays a role in a subset of these reactions. Although examination of DTH and IgE-mediated passive anaphylaxis showed no difference between wild-type and FLAP-deficient animals, mice without FLAP possessed a blunted inflammatory response to topical AA and had increased resistance to platelet-activating factor–induced shock compared to controls. Also, edema associated with Zymosan A–induced peritonitis was markedly reduced in animals lacking FLAP. To determine whether these differences relate solely to a deficit in leukotriene production, or whether they reflect an additional role for FLAP in inflammation, we compared the FLAP-deficient mice to 5-LO–deficient animals. Evaluation of mice lacking FLAP and 5-LO indicated that production of leukotrienes during inflammatory responses is dependent upon the availability of FLAP and did not support additional functions for FLAP beyond its role in leukotriene production.
Coherent spin mixing dynamics in thermal $^{87}$Rb spin-1 and spin-2 gases
Creators: name: He, Xiaodong
name: Zhu, Bing
name: Li, Xiaoke
name: Wang, Fudong
name: Xu, Zhifang
name: Wang, Dajun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We study the non-equilibrium coherent spin mixing dynamics in ferromagnetic spin-1 and antiferromagnetic spin-2 thermal gases of ultracold $^{87}$Rb atoms. Long lasting spin population oscillations with magnetic field dependent resonances are observed in both cases. Our observations are well reproduced by Boltzmann equations of the Wigner distribution function. Compared to the equation of motion of spinor Bose-Einstein condensates, the only difference here is a factor of two increase in the spin-dependent interaction, which is confirmed directly in the spin-2 case by measuring the relation between the oscillation amplitude and the sample's density.
description: 2 figures
Adhesion and material transfer between contacting Al and TiN surfaces from first principles
Creators: name: Feldbauer, Gregor
name: Wolloch, Michael
name: Bedolla, Pedro O.
name: Mohn, Peter
name: Redinger, Josef
name: Vernes, András
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A series of density functional theory (DFT) simulations was performed to investigate the approach, contact, and subsequent separation of two atomically flat surfaces consisting of different materials. Aluminum (Al) and titanium nitride (TiN) slabs were chosen as a model system representing a metal-ceramic interface and the interaction between soft and hard materials. The approach and separation were simulated by moving one slab in discrete steps normal to the surfaces allowing for electronic and atomic relaxations after each step. Various configurations were analyzed by considering (001), (011), and (111) surfaces as well as several lateral arrangements of these surfaces at the interface. Several tests were conducted on the computational setup, for example, by changing the system size or using different approximations for the exchange correlation functional. The performed simulations revealed the influences of these aspects on adhesion, equilibrium distance, and material transfer. These interfacial properties depend sensitively on the chosen configuration due to distinct bond situations. Material transfer, in particular, was observed if the absolute value of the adhesion energy for a given configuration is larger than the energy cost to remove surface layers. This result was found to be independent of the employed exchange correlation functional. Furthermore, it was shown that a simple comparison of the surface energies of the slabs is not sufficient to predict the occurrence of material transfer.
description: 14 pages, 11 figures
SYSTÈME NERVEUX DE LA TROMPE DE NOTOMASTUS LATERICEUS (SARS) (ANNÉLIDE POLYCHÈTE SÉDENTAIRE, CAPITELLIDAE)
Creators: name: MICHEL, Catherine
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: The proboscis of Notomastus latericeus (Sars) is provided with two pairs of nerves issuing from the circumoesophageal connectives. These four nerves ramify several times; they are connected by a rich subepithelial plexus with longitudinal and transversal varicose fibers in connection with the neurosensory cells of the papillae. To the oesophageal bound the longitudinal nerves join a nervous ring from which are issued bipolary neurons, nervous filaments providing oesophageal glands and retractor muscles of proboscis and the oesophageal nerves.
Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses
Creators: name: Famiglietti, Sara
name: Cambier, John C.
name: Lang, Paul
name: Nemazee, David
name: Kay, Brian K.
name: Lacaud, Georges
name: Rider, James E.
name: Kouskoff, Valerie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The B cell receptor (BCR) triggers a variety of biological responses that differ depending upon the properties of the antigen. A panel of M13 phage-displayed peptide ligands with varying affinity for the 3-83 antibody was generated to explore the role of antigen-BCR affinity in cell activation studies using primary 3-83 transgenic mouse B cells. Multiple parameters of activation were measured. T cell–independent B cell proliferation, antibody secretion, induction of germline immunoglobulin γ1 transcripts, and B cell production of interleukin (IL) 2 and interferon γ responses were better correlated with antigen-BCR affinity than with receptor occupancy. In contrast, other responses, such as upregulation of major histocompatibility complex class II and B7.2 (CD86), secretion of IL-6, and B cell proliferation in the context of CD40 signaling were only weakly dependent on antigen affinity. Biochemical analysis revealed that at saturating ligand concentrations the ability of phage to stimulate some early signaling responses, such as Ca++ mobilization and tyrosine phosphorylation of syk or Igα, was highly affinity dependent, whereas the ability to stimulate Lyn phosphorylation was less so. These data suggest that the BCR is capable of differential signaling. The possibility that differential BCR signaling by antigen determines whether an antibody response will be T independent or dependent is discussed.
Leistungseffekte des Zentralabiturs? Eine kritische Auseinandersetzung mit bildungsökonomischen Interpretationen zu den Effekten der Prüfungsorganisation auf der Basis von PISA-E-2003-Daten [Einzelbeitrag]
Creators: name: Block, Rainer
name: Klein, Esther Dominique
name: Van Ackeren, Isabell
name: Kühn, Svenja Mareike
Publisher: name: bildungsforschung
Year: 2011

description: Bildungsökonomisch ausgerichtete Sekundäranalysen von PISA-Datensätzen kommen zu dem Schluss, dass mit dem Zentralabitur in der BRD ausgeprägte Leistungseffekte einhergehen. Sie sind Ausgangspunkt bildungspolitischer Empfehlungen zur Prüfungsorganisation. Die theoretischen und methodischen Grundlagen solcher Analysen erweisen sich gleichwohl als diskussionswürdig. Im Rahmen eigener Sekundäranalysen der PISA-E-2003-Daten konnten generelle und substanzielle Leistungseffekte des Zentralabiturs nicht repliziert werden.
description: bildungsforschung, Bd. 1 (2011): Bild, Bildung und Erziehung
Llojet autoktone të misrit në rajonin Pukë
Creators: name: PR-02-Albania Team
Publisher: name: ITPGRFA
Year: 2019
Subjects: PR-02
ALB
ITPGRFA-BSF
Maize
Conservation
Farmers
Crop diversity
Beans
Breeding
Production
Characterization and evaluation
Native varieties

description: This leaflet was produced in the framework of the project "Identification, evaluation and genetic improvement of some local crop varieties to face with impact of climate change, increase the productivity, food security and on-farm incomes, for poor farmers in remote mountainous areas in Albania" funded by the 4th cycle of the Benefit Sharing Fund (BSF) of the International Treaty on Plant Genetic Resources for Food and Agriculture ( ITPGRFA).

The project aimed at introducing improved local varieties of maize and beans and worked towards the identification of local varieties of maize and beans, their collection, characterization, selection and pre-breeding including on-farm multiplication of  improved varieties of maize and bean.

This leaflet is a summary description of the indigenous maize varieties identified by project staff in the Pukë region of Albania. It highlights the morphological characteristics of different maize varieties, their growing period and ideal growing conditions, including farming technologies.
B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M + B Cell Precursor in B-1 Cell Differentiation
Creators: name: Clarke, Stephen H.
name: Arnold, Larry W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subset. Analysis of anti-PtC (VH12 and VH12/Vκ4) transgenic (Tg) mice indicates that exclusion from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement. This predicts that PtC-specific B-0 cells are generated, but subsequently eliminated by either apoptosis or differentiation to B-1. To investigate the mechanism of exclusion, PtC-specific B cell differentiation was examined in mice expressing the X-linked immunodeficiency (xid) mutation. xid mice lack functional Bruton's tyrosine kinase (Btk), a component of the B cell receptor signal transduction pathway, and are deficient in B-1 cell development. We find in C57BL/ 6.xid mice that VH12 pre-BII cell selection is normal and that PtC-specific B cells undergo modest clonal expansion. However, the majority of splenic PtC-specific B cells in anti-PtC Tg/xid mice are B-0, rather than B-1 as in their non-xid counterparts. These data indicate that PtC-specific B-0 cell generation precedes segregation as predicted, and that Btk function is required for efficient segregation to B-1. Since xid mice exhibit defective B cell differentiation, not programmed cell death, these data are most consistent with an inability of PtC-specific B-0 cells to convert to B-1 and a single B cell lineage.
Binding of Complement Factor H to Loop 5 of Porin Protein 1A: A Molecular Mechanism of Serum Resistance of Nonsialylated Neisseria gonorrhoeae
Creators: name: Ram, Sanjay
name: Pangburn, Michael K.
name: Gulati, Sunita
name: Rice, Peter A.
name: Elkins, Christopher
name: McQuillen, Daniel P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Neisseria gonorrhoeae isolated from patients with disseminated infection are often of the porin (Por1A) serotype and resist killing by nonimmune normal human serum. The molecular basis of this resistance (termed stable serum resistance) in these strains has not been fully defined but is not related to sialylation of lipooligosaccharide. Here we demonstrate that Por1A bearing gonococcal strains bind more factor H, a critical downregulator of the alternative complement pathway, than their Por1B counterparts. This results in a sevenfold reduction in C3b, which is >75% converted to iC3b. Factor H binding to isogenic gonococcal strains that differed only in their porin serotype, confirmed that Por1A was the acceptor molecule for factor H. We identified a surface exposed region on the Por1A molecule that served as the binding site for factor H. We used gonococcal strains with hybrid Por1A/B molecules that differed in their surface exposed domains to localize the factor H binding site to loop 5 of Por1A. This was confirmed by inhibition of factor H binding using synthetic peptides corresponding to the putative exposed regions of the porin loops. The addition of Por1A loop 5 peptide in a serum bactericidal assay, which inhibited binding of factor H to the bacterial surface, permitted 50% killing of an otherwise completely serum resistant gonococcal strain. Collectively, these data provide a molecular basis to explain serum resistance of Por1A strains of N. gonorrhoeae.
Les nématodes libres, organismes-sentinelles de l'évolution des concentrations d'hydrocarbures dans la baie de Bizerte (Tunisie)
Creators: name: BEYREM, Hamouda
name: AISSA, Patricia
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: Free-living nematodes, bio-indicators of the evolution of hydrocarbon concentrations in the bay of Bizerta
 (Tunisia). A first monitoring in the bay of Bizerta during July 1992, based upon seven sampling stations, indicated a refinery
 and tankers, berthing at proximity, to be the cause of high amounts of hydrocarbon noted in the region. The nematodes,
 omnipresent, show a statistically significant decrease in densities, biomasses and specific diversity, in relation to
 concentrations of hydrocarbon deposited in sediments. After an apparent improvement of the quality of waste waters
 discharged by the refinery, a similar study was repeated in July 1996. The results indicate an increasing amount of
 hydrocarbons in the sediments in 1996 to which the nematodes have responded by a quantitative and qualitative
 impoverishment of their community.
(1884) Grace Reid
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Compensatory Prostaglandin E 2 Biosynthesis in Cyclooxygenase 1 or 2 Null Cells
Creators: name: Ballou, Leslie R.
name: Kanekura, Takuro
name: Goorha, Sarita
name: Laulederkind, Stanley J.F.
name: Morham, Scott G.
name: Raghow, Rajendra
name: Kirtikara, Kanyawim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Prostaglandin E2 (PGE2) production in immortalized, nontransformed cells derived from wild-type, cyclooxygenase 1–deficient (COX-1−/−) or cyclooxygenase 2–deficient (COX-2−/−) mice was examined after treatment with interleukin (IL)-1β, tumor necrosis factor α, acidic fibroblast growth factor, and phorbol ester (phorbol myristate acetate). Compared with their wild-type counterparts, COX-1−/− or COX-2−/− cells exhibited substantially enhanced expression of the remaining functional COX gene. Furthermore, both basal and IL-1–induced expression of cytosolic phospholipase A2 (cPLA2), a key enzyme-regulating substrate mobilization for PGE2 biosynthesis, was also more pronounced in both COX-1−/− and COX-2−/− cells. Thus, COX-1−/− and COX-2−/− cells have the ability to coordinate the upregulation of the alternate COX isozyme as well as cPLA2 genes to overcome defects in prostaglandin biosynthetic machinery. The potential for cells to alter and thereby compensate for defects in the expression of specific genes such as COX has significant clinical implications given the central role of COX in a variety of disease processes and the widespread use of COX inhibitors as therapeutic agents.
The Specificity of Peptides Bound to Human Histocompatibility Leukocyte Antigen (HLA)-B27 Influences the Prevalence of Arthritis in HLA-B27 Transgenic Rats
Creators: name: Maika, Shanna D.
name: Bordoli, Robert S.
name: Gaskell, Simon J.
name: Taurog, Joel D.
name: Sayad, Alain
name: Slaughter, Clive A.
name: Satumtira, Nimman
name: Jones, Richard C.
name: Zhou, By Ming
name: Dorris, Martha L.
name: Simmons, William A.
name: Sartor, R. Balfour
name: Richardson, James A.
name: Hammer, Robert E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Human histocompatibility leukocyte antigen B27 is highly associated with the rheumatic diseases termed spondyloarthropathies, but the mechanism is not known. B27 transgenic rats develop a spontaneous disease resembling the human spondyloarthropathies that includes arthritis and colitis. To investigate whether this disease requires the binding of specific peptides to B27, we made a minigene construct in which a peptide from influenza nucleoprotein, NP383-391 (SRYWAIRTR), which binds B27 with high affinity, is targeted directly to the ER by the signal peptide of the adenovirus E3/gp19 protein. Rats transgenic for this minigene, NP1, were made and bred with B27 rats. The production of the NP383-391 peptide in B27+NP1+ rats was confirmed immunologically and by mass spectrometry. The NP1 product displaced ∼90% of the 3H-Arg-labeled endogenous peptide fraction in B27+NP1+ spleen cells. Male B27+NP1+ rats had a significantly reduced prevalence of arthritis, compared with B27+NP− males or B27+ males with a control construct, NP2, whereas colitis was not significantly affected by the NP1 transgene. These findings support the hypothesis that B27-related arthritis requires binding of a specific peptide or set of peptides to B27, and they demonstrate a method for efficient transgenic targeting of peptides to the ER.
Lehren und Lernen neu: digitale Geo-Medien im Schulunterricht
Creators: name: Lindner-Fally, Michaela
Publisher: name: bildungsforschung
Year: 2012

description: Dieser Beitrag diskutiert didaktische Potentiale und Herausforderungen, die neue digitale Geo-Medien für den Schulunterricht bieten. Neben der Präsentation von Kompetenzstufen-Modellen und Lehrplan-Ansätzen werden sowohl die historische Entwicklung, der aktuelle Forschungsstand bzw. die gegenwärtige Umsetzung der skizzierten Lernprozesse in Ã–sterreich und Europa dargestellt. Zum Schluss werden die aus den aktuellen Entwicklungen abgeleiteten Ziele und Herausforderungen im Rahmen des Netzwerks „digital-earth.eu“ vorgestellt.
description: bildungsforschung, Bd. 1 (2012): Wandel von Lern- und Lehrmaterialien
Selection at Multiple Checkpoints Focuses V H 12 B Cell Differentiation toward a Single B-1 Cell Specificity
Creators: name: Ye, Jian
name: Arnold, Larry W.
name: Clarke, Stephen H.
name: Tatu, Calin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 10% of the B-1 repertoire. About half express VH12 and Vκ4/5H and are restricted in VHCDR3. We have previously reported that anti-PtC VHCDR3 is enriched among VH12-expressing cells by selective elimination of pre-B cells. We report here a bias for Vκ4/5H expression among VH12-expressing B cells, even among those that do not bind PtC and are not B-1. This is due in part to an inability of VH12 to associate with many light (L) chains but must also be due to a selective advantage in survival or clonal expansion in the periphery for Vκ4/5H-expressing cells. Thus, the bias for Vκ4/5H expression is independent of PtC binding, and, as segregation to B-1 occurs after Ig gene expression, it precedes segregation to the B-1 subset. In 6-1 mice, splenic B-1 cells reside in follicles but segregate to follicles distinct from those that contain B-2 cells. These data indicate that selection at multiple developmental checkpoints ensures the co-expression of an anti-PtC VHCDR3 and L chain in a high frequency of VH12 B cells. This focus toward specificity for PtC facilitates the development of a large anti-PtC B-1 repertoire.
(2657) Mary [Clark]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
E-Books in der Schule: Eine Evaluierung von E-Book-Formaten und E-Book-Readern hinsichtlich ihrer Eignung für Schulbücher
Creators: name: König, Monika
name: Ebner, Martin
Publisher: name: bildungsforschung
Year: 2012

description: Das Schulbuch ist als Lehrmittel unserer Zeit kaum mehr wegzudenken, obwohl es noch gar nicht so lange her war, dass man auch ohne auskam. Seit der Jahrtausendwende halten die digitalen Technologien im Sog des World Wide Web immer mehr Einzug im Klassenzimmer und spätestens seit der Einführung des iPads der Firma Apple bzw. des Kindle von Amazon.com nimmt die Diskussion rund um E-Books immer mehr zu. In diesem Beitrag soll versucht werden die derzeitigen Möglichkeiten zu beleuchten und der Frage nach zu gehen, ob aus technischer Sicht Schulbücher als E-Book denkbar sind. Neben der Frage „Was denn ein gutes Schulbuch ist“, werden E-Book-Formate und E-Book-Endgeräte dargestellt und anhand von praktischen Tests gezeigt, wo die Grenzen der Technik sind. Es kann zusammengefasst werden, dass es aus Sicht der Autoren völlig klar ist, dass die Digitalisierung von Büchern weiter voranschreitet, aber dass es bis zum Einsatz in der Praxis noch ein großer Schritt ist.
description: bildungsforschung, Bd. 1 (2012): Wandel von Lern- und Lehrmaterialien
Additional file 1 of Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA
Creators: name: Peruzzo, Paolo
name: Bergamin, Natascha
name: Bon, Martina
name: Cappelli, Sara
name: Longo, Alessandra
name: Goina, Elisa
name: Stuani, Cristiana
name: Buratti, Emanuele
name: Dardis, Andrea
Publisher: name: figshare
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biological Sciences not elsewhere classified

description: Additional file 1.
E-Schulbücher, iPads und Interpassivität: Reflexionen über neue schulische Bildungsmedien und deren Subjektivationspotential
Creators: name: Macgilchrist, Felicitas
Publisher: name: bildungsforschung
Year: 2012

description: Ziel dieses Beitrags ist, eine medien- und diskurstheoretisch gestützte explorative Reflexion der neuen digitalen Schulbücher zu entfalten. Mithilfe des Konzepts des Angebots werden drei (zusammenhängende) Aspekte der neuen E-Schulbücher betrachtet: die Materialität; die angebotenen sozialen Relationen; und die Interaktivität bzw. Interpassivität dieser E-Schulbüchern. Inwieweit sind E-Schulbücher im „Medienleben“ von jungen Menschen verankert bzw. welches neue Schüler-Subjekt wird potentiell von ihnen entworfen? Ein zentraler Aspekt des Medienlebens, Produsage, wird von heutigen E-Schulbüchern nicht angeboten. Der Beitrag diskutiert auch die Potentiale der von Aktivist/innen, Lehrenden, NGOs usw. produzierten E-Schulbücher für die Verbreitung von nicht-hegemonialen Wissens- und Subjektivationsformen.
description: bildungsforschung, Bd. 1 (2012): Wandel von Lern- und Lehrmaterialien
Thermal metamorphism of the mantle peridotites from Paleozoic accretionary prism by the Eocene pluton (NE of Anarak, Kal-e-Kafi area, Central Iran)
Creators: name: Zakipour, Zahraalsadat
name: Torabi, Ghodrat
name: Kazuo, Nakashima
name: Morishita, Tomoaki
Publisher: name: Periodico di Mineralogia
Year: 2022

description: The Eocene pluton cross cut the Paleozoic accretionary wedge in the Kal-e-Kafi area (NE of Anarak, Isfahan province, Central Iran). Metaperidotites of this Paleotethys- related accretionary prism are consist of metalherzolite, metaharzburgite and metadunite and are associated with the listwaenites and metasediments (schist and marble). Rock-forming minerals of the Kal-e-Kafi metaperidotites are olivine (forsterite and chrysolite, Mg#= 0.86-0.92 with CaO<0.02 wt%), orthopyroxene (enstatite, Mg#= 0.84-0.86), clinopyroxene (Mg#= 0.90-0.94, Al2O3 0.03-2.08 wt%), tremolite, tremolitic-hornblende and magnesio-hornblende, anthophyllite, serpentine (antigorite with Mg#= 0.82-0.95), talc, chlorite (clinochlore, Mg#= 0.94-0.95), chromian spinel (Cr#= 0.58-0.72), magnetite and plagioclase (Anorthite An0.91-0.95). All these minerals are metamorphic products and are not relicts of the primary igneous mineralogy, except the inner parts of Cr-spinels. The main textures of these rocks are porphyroblastic, granoblastic, nematoblastic, poikiloblastic, jack-straw and mesh texture. Chemical composition of core of Cr-spinels reveal that the protolith of the studied rocks were mantle peridotites which belong to the depleted and moderately depleted peridotite series. Mineral chemistry of clinopyroxenes (Cr2O3= 0-0.06 wt%, Al2O3= 0.03-2.08 wt%, average TiO2 value of 0.036 wt%, and trace element patterns in the normalization diagrams) indicate their metamorphic nature The results of the field study (association of metaperidotites with Paleozoic schist and marbles), petrography evidences (the presence of metamorphic mineral assemblages of tremolite + olivine and olivine + orthopyroxene + anthophyllite), chemical characteristics of minerals (the average forsterite content of olivine neoblasts is ~90; extensive variation in MnO content of olivines; the high value of Al2O3 in chlorite; low Cr2O3, Al2O3 and TiO2 contents of clinopyroxenes, and presence of anorthite plagioclase) and thermobarometry calculations, show that the peridotites of the Kal-e-Kafi area have suffered a regional metamorphism in P-T condition of greenschist facies in the Paleozoic, then intrusion of the Kal-e-Kafi pluton, caused to a progressive contact metamorphism in 630 to 750 °C and at a pressure less than 1 kbar (pyroxene hornfels facies) in the Eocene. In the next stage, a retrograde metamorphism led to the formation of chlorite from tremolite and partial serpentinization of metamorphic olivines and orthopyroxenes.
description: Periodico di Mineralogia, Vol. 91 No. 2 (2022)
Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase
Creators: name: Reap, Elizabeth A.
name: Shelton Earp, H.
name: Cohen, Philip L.
name: Charles Jennette, J.
name: Matsushima, Glenn
name: Camenisch, Todd D.
name: Roubey, Robert A.S.
name: Caricchio, Roberto
name: Abraham, Valsamma
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Mice lacking the membrane tyrosine kinase c-mer have been shown to have altered macro-phage cytokine production and defective phagocytosis of apoptotic cells despite normal phagocytosis of other particles. We show here that c-mer–deficient mice have impaired clearance of infused apoptotic cells and that they develop progressive lupus-like autoimmunity, with antibodies to chromatin, DNA, and IgG. The autoimmunity appears to be driven by endogenous antigens, with little polyclonal B cell activation. These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity.
Use of Monosodium Glutamate (MSG) for Green Leaching Process: An Overview
Creators: name: Bahfie, Fathan
name: Supriadi, Muhammad Rafli
name: Oediyani, Soesaptri
name: Nurjaman, Fajar
name: Astuti, Widi
name: Prasetyo, Erik
name: Susanti, Diah
Publisher: name: Periodico di Mineralogia
Year: 2022

description: Monosodium glutamate (MSG) is a sodium salt derived from amino acids and glutamic acids. These acids can be found naturally in the body and in the variation of other foods. MSG has the chemical formula C5H8NO4Na-NH2 with the percentage of the main elements contained in MSG including glutamate of 78.2%; Na by 12.2%; and 9.6% H2O and 1 g of monosodium glutamate contains 0.122 Na. MSG also functions as a reagent in extraction processes such as the leaching process under alkaline conditions causing the glutamate to be strongly bound to metal ions and can selectively enrich unwanted elements such as Fe, Al, Mg, and Ca in residual solids. The use of MSG is not currently the optimal which can be an opportunity to develop research on extraction from the leachate process and as an additive in the selective reduction process in the future owing to the sodium content.
description: Periodico di Mineralogia, Vol. 91 No. 2 (2022)
Happy Moral Racists- Black Participants
Creators: name: King, Laura A.
name: Rose, Hope
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Personality and Social Contexts
subject: Social Psychology
subject: Psychology
subject: FOS: Psychology

description: Are happy racists viewed as morally good, compared to unhappy racists? Black participants will be randomly assigned to 1 of 4 cells in which they see fabricated responses ostensibly provided by a previous participant in another study. They will be asked to review the participant’s responses and rate the target on a series of traits relevant to moral goodness.
Application for promotion as Professor (Textile Engineering) and/or right adjustment of my designation under consideration of my Curriculum Vitae (CV), publications and teaching experiences under the promotion act of City University, Dhaka, Bangladesh; supported by the act of University Grants Commission of Bangladesh, Dhaka, Bangladesh.
Creators: name: Hossain, Anowar
Publisher: name: Zenodo
Year: 2023
Subjects: Promotion Letter; City University, Dhaka, Bangladesh

description: Application for promotion as Associate Professor (Textile Engineering) and/or right adjustment of my designation under consideration of my Curriculum Vitae (CV), publications and teaching experiences under the promotion act of City University, Dhaka, Bangladesh; supported by the act of University Grants Commission of Bangladesh, Dhaka, Bangladesh.
Evaluation of the effect of shopping centers architectural typologies on customer behavior : Erbil case studies
Creators: name: Khawola F. Mahmoud
Publisher: name: figshare
Year: 2020
Subjects: subject: 120101 Architectural Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Evaluation of the effect of shopping centers architectural typologies on customer behavior : Erbil case studies
The moduli space of twisted canonical divisors
Creators: name: Farkas, Gavril
name: Pandharipande, Rahul
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: The moduli space of canonical divisors (with prescribed zeros and poles) on nonsingular curves is not compact since the curve may degenerate. We define a proper moduli space of twisted canonical divisors in the moduli space of Deligne-Mumford stable pointed curves which includes the space of canonical divisors as an open subset. The theory leads to geometric/combinatorial constraints on the closures of the moduli spaces of canonical divisors. In case the differentials have at least one pole (the strictly meromorphic case), the moduli spaces of twisted canonical divisors on genus g curves are of pure codimension g in the moduli spaces of stable pointed curves. In addition to the closure of the canonical divisors on nonsingular curves, the moduli spaces have virtual components. In the Appendix, a complete proposal relating the sum of the fundamental classes of all components (with intrinsic multiplicities) to a formula of Pixton is proposed. The result is a precise and explicit conjecture in the tautological ring for the weighted fundamental class of the moduli spaces of twisted canonical divisors. As a consequence of the conjecture, the classes of the closures of the moduli spaces of canonical divisors on nonsingular curves are determined (both in the holomorphic and meromorphic cases).
description: Appendix on the weighted fundamental class by F. Janda, R. Pandharipande, A. Pixton, and D.Zvonkine [J. Institute Math. Jussieu, to appear]
Distribution of Luidia clathrata and Luidia lawrencei (Echinodermata: Asteroidea) along the coast of the western Atlantic Ocean, the Gulf of Mexico and the Caribbean Sea
Creators: name: LAWRENCE, John M.
name: DURÁN-GONZÁLEZ, Alicia
name: SOLÍS-MARÍN, Francisco A.
name: HERRERA, Joan
name: VENTURA, Carlos Renato R.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Clark and Downey (1992) stated the distribution of Luidia clathrata (Say, 1825) is from Virginia, USA to southern Brazil, including the Gulf of Mexico. Hopkins & Knott (2010) erected a new species, Luidia lawrencei, from L. clathrata.We examined collections to establish the identity of specimens and their distribution. Luidia clathrata is found in the Gulf of Mexico in bays and near shore off the coasts of Florida, Texas and Campeche, Mexico. It also occurs near shore in the Caribbean Sea and along the coast of the United States from Virginia to Florida and northeastern South America to southern Brazil. In contrast, L. lawrencei is not found in the Caribbean or along the coast of South America. It is found in the Gulf of Mexico off the coasts of the United States and Mexico and along the Atlantic coast of the United States from North Carolina to Florida. Luidia clathrata is found on fine substrata and L. lawrencei is found on coarse substrata.
(3750) Elizabeth Davison
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Chemical and structural characterization of UICC amosite fibres from Penge mine (South Africa)
Creators: name: Ballirano, Paolo
name: Skogby, Henrik
name: Gianchiglia, Flaminia
name: Di Carlo, Maria Cristina
name: Campopiano, Antonella
name: Cannizzaro, Annapaola
name: Olori, Angelo
name: Pacella, Alessandro
Publisher: name: Periodico di Mineralogia
Year: 2022

description: In the present work we report the full structural and spectroscopic characterization of an UICC amosite (fibrous grunerite) standard sample from Penge mine (South Africa). The chemical composition was obtained by SEM-EDS and cation site partition was retrieved by complementing chemical, Mössbauer and X-ray powder diffraction data. Cell parameters, fractional coordinates, and site scattering for M(1), M(2), M(3), M(4) were refined using the Rietveld method. The retrieved crystal chemical formula A[Na0.02]Σ0.02 B(Fe2+1.54Mn0.29Na0.10Ca0.07)Σ2.00 C(Fe2+2.92Mg1.93Fe3+0.15)Σ5.00 T(Si7.93Al0.07)Σ8.00 O22.00 W(OH2.00)Σ2.00 is in reasonable agreement with reference data. Rietveld refinement results evidenced that Fe2+ is allocated in the octahedral layer following the site preferences M(1) » M(3) > M(2), whereas Mg preferentially is ordered at M(2). Refined cell parameters are: a = 9.55264(17) Å, b = 18.3069(3) Å, c = 5.33487(8) Å, β = 101.840(3)°, V = 913.11(3) Å3. Quantitative Phase Analysis indicates about 10 wt.% of accessory phases including quartz, ankerite and minor stilpnomelane and biotite/annite. Obtained results are the basis for further studies aimed at investigating possible correlation between physico-chemical features of the fibres and their chemical reactivity and toxicity.
description: Periodico di Mineralogia, Vol. 91 No. 2 (2022)
Editorial zum Schwerpunktthema „NichtpaÌˆdagogisches Personal in Bildungseinrichtungen – Bedeutung fuÌˆr Sozialisations-, Erziehungs- und Bildungsprozesse“
Creators: name: Schmidt-Hertha, Bernhard
name: Müller, Margaretha
Publisher: name: bildungsforschung
Year: 2013

description: In diesem Beitrag wird ein kurzer Überblick über die Artikel der Ausgabe 1 (2013) zum Themenschwerpunkt „Nichtpädagogisches Personal in Bildungseinrichtungen – Bedeutung für Sozialisations-, Erziehungs- und Bildungsprozesse“ gegeben.
description: bildungsforschung, Bd. 1 (2013): Nicht-pädagogisches Personal in Bildungseinrichtungen