cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Part I. Conformational effects on the proton magnetic resonance spectra of six-membered ring compounds. Part II. A study of the effect of a 3-methoxy group on the stereochemical routes and the reactivities of a variety of 1,2-substituted cyclohexanes.
Creators: name: Kullnig, Rudolph K.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1958
Subjects: subject: Chemistry, Organic.

description: Part one. The NMR spectra of six-membered ring compounds show an approximately three times larger spin coupling constant for 1,2-diaxial hydrogen atoms than for 1,2-hydrogen atoms in other conformational relationship. Signals for equatorial hydrogen atoms are generally found at lower fields than those for the corresponding axial hydrogen atoms. The signals of equatorial acetoxy or methoxy groups, however, are usually observed at higher fields than their axial equivalent. The observations are applied to several determinations of configuration and conformation with emphasis on the acetylated aldopyranoses and some theoretical implications of the results are discussed. Part two. It was found possible to assign the structures and configurations to two of the diastereoisomeric 1,3-dimethoxy-2-acetoxycyclohexanes on the basis of their NMR spectra and thereby assign configurations to the parent diastereoisomeric 3-methoxycyclohexene oxides. The conclusions thus reached were substantiated by chemical means. Two new isomeric 3-methoxy-1,2-cyclohexanediols were isolated and their structures were established. The rates of the periodate oxidation of these compounds and of the other two previously known isomers were examined. Furthermore, the relative electrophoretic mobilities of the four isomers, on borate buffered filter paper, were determined. The structures and configurations of the epimeric 3-methoxy derivatives of trans-1-tosyloxy-2-acetoxycyclohexane were established and the rates of their acetolyses measured. The results of the rate studies and electrophoretic migration measurements are discussed in terms of interactions between the 3-methoxy groups and the 1,2-cyclic ions formed as reaction intermediates.
Are We Delivering Optimal Pulmonary Rehabilitation? : The Importance of Quality Indicators in Evaluating Clinical Practice
Creators: name: Camp, Pat
name: Cheung, Walden A.
Publisher: name: The University of British Columbia
Year: 2018

description: Pulmonary rehabilitation (PR) is a complex intervention that has been shown to improve exercise capacity and quality of life, reduce dyspnea, and decrease the risk of exacerbations and hospitalization. Although the evidence for PR is strong, the translation of this evidence into clinical practice remains a challenge, and important gaps in care exist. To date, most research in PR has focused on questions related to treatment efficacy. Less attention has been paid to confirming whether the strong evidence base of PR has been effectively translated to this complex clinical setting. Policy makers and other stakeholders in PR are calling for the establishment of core standards and quality indicators in PR to evaluate existing programs and improve patient care. However, what are quality indicators, and how are they used? This Perspective explores quality assurance in the context of PR and introduces the concepts and uses of quality indicators that can be used to evaluate and improve the quality of care.
Covid-19 vaccine safety in special populations
Creators: name: Soe, Phyu Mar
Publisher: name: University of British Columbia
Year: 2025

description: Post-marketing surveillance is important for COVID-19 vaccines following initial emergency approval, particularly for populations not included in pre-approval studies. This dissertation characterizes the safety of mRNA COVID-19 vaccines using post-approval surveillance data in three distinct groups: older adults (≥65 years), pediatric populations (<20 years), and individuals with autoimmune diseases. Additionally, it examines the impact of different recruitment methods on participation rates in vaccine safety surveys. Data were sourced from the Canadian National Vaccine Safety Network (CANVAS) during the pandemic and included both vaccinated and unvaccinated individuals from seven Canadian provinces and territories. The outcomes of interest were health events that prevented daily activities, resulted in school/work absenteeism, or required medical consultation. Analyses profiled adverse events and adverse events of special interest (AESIs) following each mRNA COVID-19 vaccine product and dose, and evaluated health events associated with vaccination. Among the different recruitment methods used in the CANVAS active surveillance study, technology-assisted recruitment through vaccine registries proved the most effective in reaching and retaining a large, diverse sample. Across all study populations, the most frequently reported symptoms following any dose of mRNA COVID vaccine were local and systemic symptoms, such as feeling unwell, fever, and headache, and most were self-limited and resolved within seven days. Vaccinated older adults and adolescents reported a higher frequency of health events within seven days after the second mRNA COVID-19 vaccine dose (limited to mRNA-1273 for older adults) compared to their unvaccinated counterparts. Emergency care utilization among vaccinated individuals within seven months after the first dose was similar to or lower than among unvaccinated individuals. Among individuals with autoimmune diseases, the frequency of health events was similar within a week following the co-administration of COVID-19 and influenza vaccines and the administration of the COVID-19 vaccine alone, indicating no additional risk from co-administration. This dissertation provides important evidence on the safety profiles of mRNA COVID-19 vaccines, offering valuable insights to inform vaccination policies in Canada and globally. These findings support effective communication about COVID-19 vaccine safety, helping vulnerable populations make informed decisions.
Comparison of distinctive models for calculating an interlobar emphysema heterogeneity index in patients prior to endoscopic lung volume reduction
Creators: name: Theilig, Dorothea
name: Doellinger, Felix
name: Poellinger, Alexander
name: Schreiter, Vera
name: Neumann, Konrad
name: Hubner, Ralf-Harto
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: CT-quantitative
subject: COPD
subject: emphysema heterogeneity
subject: endoscopic lung volume reduction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: The degree of interlobar emphysema heterogeneity is thought to play an important role in the outcome of endoscopic lung volume reduction (ELVR) therapy of patients with advanced COPD. There are multiple ways one could possibly define interlobar emphysema heterogeneity, and there is no standardized definition. Purpose: The aim of this study was to derive a formula for calculating an interlobar emphysema heterogeneity index (HI) when evaluating a patient for ELVR. Furthermore, an attempt was made to identify a threshold for relevant interlobar emphysema heterogeneity with regard to ELVR. Patients and methods: We retrospectively analyzed 50 patients who had undergone technically successful ELVR with placement of one-way valves at our institution and had received lung function tests and computed tomography scans before and after treatment. Predictive accuracy of the different methods for HI calculation was assessed with receiver-operating characteristic curve analysis, assuming a minimum difference in forced expiratory volume in 1 second of 100 mL to indicate a clinically important change. Results: The HI defined as emphysema score of the targeted lobe (TL) minus emphysema score of the ipsilateral nontargeted lobe disregarding the middle lobe yielded the best predicative accuracy (AUC =0.73, P=0.008). The HI defined as emphysema score of the TL minus emphysema score of the lung without the TL showed a similarly good predictive accuracy (AUC =0.72, P=0.009). Subgroup analysis suggests that the impact of interlobar emphysema heterogeneity is of greater importance in patients with upper lobe predominant emphysema than in patients with lower lobe predominant emphysema. Conclusion: This study reveals the most appropriate ways of calculating an interlobar emphysema heterogeneity with regard to ELVR.
Developmental regulation of the monoamine fear circuitry
Creators: name: Jacobsen, Kirsten
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Molecular.
subject: Biology, Neuroscience.

description: The central thesis of these studies was to examine the regulatory mechanisms that govern the development of neurotransmitter systems of the mammalian monoamine fear circuitry. We first examined the central orchestrator of the monoamine fear circuitry, the extended amygdala, comprised of the amygdala proper, as well as its rostral extension along the bed nucleus of the stria terminalis to the shell of the nucleus accumbens. We identified a series of GABAergic gating structures along the entire rostro-caudal axis of the extended amygdala that are dopamine D1 receptor rich, but have variable dopamine-like terminal input. In addition, we identified a complimentary distribution of the micro-opioid receptor 1, which also receives variable opioid peptide terminal input. We proposed a model in which the regions lacking direct terminal input maintain a tonic inhibition of amygdaloid fear outputs, whereas the regions receiving direct dopaminergic input disinhibit amygdaloid behavioural outputs, enhancing fear response. Following on from these brain circuitry studies we turned our attention to the critical developmental regulators of the monoamine fear circuitry. We first examined how a Parkinson's disease mutation in the transcription factor NURR1, might lead to impairment in dopamine development that may also affect fear circuitry. We also investigated, in vivo and in vitro, two transcriptional regulators that control development of the serotonin system (Pet-1 and Hes1) and how they impact serotonergic modulation of receptor expression. In vitro we showed Pet-1 and Hes1 directly enhance or repress, respectively, the expression of serotonin-1A receptors. Using mouse models lacking Pet-1, which specifically promotes serotonergic differentiation, we found unexpected compensatory alterations in the regulation of pre- and post-synaptic serotonin-1A receptors. In mice lacking Hes1, which restricts neuronal differentiation, we observed striking up-regulation receptor expression. Taken together, these studies provide (1) an anatomical template for understanding how emotionally relevant stimuli, including the subjective experience of stress, are processed by the extended amygdala, the core of the monoamine fear circuitry and (2) a molecular explanation for how this processing machinery may be predisposed to certain emotional or behavioural responses via early developmental regulatory events.
A role for the Ste20-like kinase, SLK, in cell migration
Creators: name: Wagner, Simona M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Cell.

description: The Ste20-like kinase (SLK) is a conserved serine-threonine kinase that is involved in cytoskeletal reorganization and apoptosis (Sabourin and Rudnicki, 1999; Sabourin et al., 2000). Overexpression of SLK in various cell lines was shown to induce the rapid disassembly of actin stress fibres and cell death (Sabourin et al., 2000). To investigate the physiological role of SLK we used MEF-3T3 fibroblasts spreading and migrating on fibronectin coated substrates. Using immunofluorescence studies, we report that SLK is redistributed with adhesion components at podosome-like adhesion sites in fibronectin stimulated fibroblasts. Furthermore, we show that SLK is associated with the microtubule network and can be co-precipitated with alpha-tubulin. However, in vitro kinase assays demonstrate that its activity in not modulated following fibronectin stimulation. Using microinjection studies, we show that ectopic expression of activated SLK induces the disassembly of actin stress fibres, a process that can be inhibited by dominant negative Rac1. Furthermore, the overexpression of SLK by adenoviral infection inhibits cell spreading on fibronectin. As the signalling pathways activated during cell spreading also regulate cell motility we tested the possibility that SLK may play a role in cell migration (Mitra and Schlaepfer, 2006; Webb et al., 2002). We first investigated the localization of SLK and other cytoskeletal markers following scratch wounding of fibroblasts monolayers, and observed that SLK is recruited at the leading edge of migrating cells with paxillin, Rac1 and the microtubules. Using short interfering RNA and dominant negative approaches, we show that SLK is required for microtubule-dependent focal adhesion turnover and cell migration. Scratch wounding of confluent monolayers have been shown to induce polarization and migration (Etienne-Manneville and Hall, 2001). Therefore, we investigated SLK kinase activity following scratch wound induced migration and report that SLK is activated during migration. In addition, we report that SLK activation is dependent on a multitude of signalling pathways such as FAK/c-Src, MAPK, PI3K and RhoGTPases, whereas SLK recruitment to the leading edge is Src-dependent but FAK-independent. Overall, we have established a role for SLK in cell motility as a novel molecular link between the adhesion-destabilizing activity of the microtubule network and actin-based cytoskeletal remodelling events.
Economic attitudes of members in the Ottawa Sarang Presbyterian Church
Creators: name: Yoo, Kwangsuk
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Religion, General.

description: My academic interest was and is in the problem of the interplay between religion and economy. Based purely on this academic interest, I visited the Ottawa Sarang Presbyterian Church (OSPC) established in 2004 and became its member. I decided to be baptized at this church, which I had intentionally delayed for a long time. During the survey of the OSPC members, I came to have a serious interest in the community of Korean immigrants that did not attract much attention in terms of the sociology of religion. After that, the subject of my Master thesis was going toward the relationship among religion, economy, and globalization. This thesis is just a beginning for deepening my understanding of the issue. I hope that this thesis may contribute to a better understanding of Korean immigrants in Canada, and I heartily appreciate the participation of the OSPC members in the survey. Further, I greatly owed the completion of this thesis to my wife and Dr. Peter Beyer. I thank all of them once again.
Measurement of inclusive radiative B-meson decays with a photon energy threshold of 1.7 GeV
Creators: name: Limosani, A.
name: Aihara, H.
name: Arinstein, K.
name: Aushev, T.
name: Bakich, A. M.
name: Balagura, V.
name: Barberio, E.
name: Bay, A.
name: Belous, K.
name: Bischofberger, M.
name: Bondar, A.
name: Bozek, A.
name: Bračko, M.
name: Browder, T. E.
name: Chang, P.
name: Chao, Y.
name: Chen, A.
name: Cheon, B. G.
name: Choi, Y.
name: Dalseno, J.
name: Danilov, M.
name: Drutskoy, A.
name: Dungel, W.
name: Eidelman, S.
name: Goldenzweig, P.
name: Golob, B.
name: Ha, H.
name: Hayashii, H.
name: Hoshi, Y.
name: Hou, W. S.
name: Hyun, H. J.
name: Inami, K.
name: Itoh, R.
name: Iwasaki, Y.
name: Julius, T'Mir
name: Kah, D. H.
name: Kim, H. O.
name: Kim, S. K.
name: Kim, Y. I.
name: Kim, Y. J.
name: Kinoshita, K.
name: Ko, B. R.
name: Korpar, S.
name: Kreps, M.
name: Križan, P.
name: Krokovny, P.
name: Kuhr, T.
name: Kumar, R.
name: Kwon, Y. J.
name: Kyeong, S. H.
name: Lesiak, T.
name: Li, J.
name: Liu, Chang
name: Liventsev, D.
name: Louvot, R.
name: Matyja, A.
name: Miyabayashi, K.
name: Miyata, H.
name: Miyazaki, Y.
name: Mizuk, R.
name: Mori, T.
name: Nakao, M.
name: Nakazawa, H.
name: Nishida, S.
name: Nishimura, K.
name: Nitoh, O.
name: Nozaki, T.
name: Ogawa, S.
name: Ohshima, T.
name: Okuno, S.
name: Ozaki, H.
name: Pakhlova, G.
name: Park, C. W.
name: Park, H.
name: Piilonen, L. E.
name: Rozanska, M.
name: Sahoo, H.
name: Sakai, Y.
name: Schneider, O.
name: Schümann, J.
name: Schwanda, C.
name: Schwartz, A. J.
name: Senyo, K.
name: Sevior, M. E.
name: Shapkin, M.
name: Shebalin, V.
name: Shen, C. P.
name: Shiu, J. G.
name: Singh, J. B.
name: Stanič, S.
name: Starič, M.
name: Sumisawa, K.
name: Sumiyoshi, T.
name: Suzuki, S.
name: Taylor, G. N.
name: Teramoto, Y.
name: Trabelsi, K.
name: Tsuboyama, T.
name: Uehara, S.
name: Unno, Y.
name: Uno, S.
name: Urquijo, P.
name: Ushiroda, Y.
name: Varner, G.
name: Varvell, K. E.
name: Vervink, K.
name: Wang, C. H.
name: Wang, M. Z.
name: Wang, P.
name: Watanabe, Y.
name: Wedd, R.
name: Wicht, J.
name: Won, E.
name: Yabsley, B. D.
name: Yamamoto, H.
name: Yamashita, Y.
name: Zhang, Z. P.
name: Zivko, T.
name: Zupanc, A.
Publisher: name: Swinburne
Year: 2024

description: Using 605fb-1 of data collected at the Υ(4S) resonance we present a measurement of the inclusive radiative B-meson decay channel, B→Xsγ. For the lower photon energy thresholds of 1.7, 1.8, 1.9, and 2.0 GeV, as defined in the rest frame of the B meson, we measure the partial branching fraction and the mean and variance of the photon energy spectrum. At the 1.7 GeV threshold we obtain the partial branching fraction BF(B→Xsγ)=(3.45±0. 15±0.40)×10-4, where the errors are statistical and systematic.
Ambient fine particulate matter (PM₂.₅) and depressive symptoms : a cross-sectional study of 21 countries
Creators: name: Zdero, Svetlana
Publisher: name: University of British Columbia
Year: 2025

description: Background: Emerging evidence suggests that long-term exposure to outdoor fine particulate matter (PM₂.₅) may increase the risk of major depressive disorder (MDD). However, few studies have explored this relationship in low- and middle-income countries, where individuals disproportionately experience higher disease burden from air pollution exposure and higher risk for poor mental health. This study aimed to characterize associations between ambient PM₂.₅ exposure and depressive symptoms within urban and rural communities in 21 high-, middle-, and low-income countries. Methods: This cross-sectional analysis used baseline data from the Prospective Urban Rural Epidemiology (PURE) cohort. Adults aged 35-70 completed the Short-Form Composite International Diagnostic Interview (CIDI-SF), where ⩾4 of 7 depressive symptoms was predictive of MDD. Participants were assigned community-level annual average PM₂.₅ estimates for the year before cohort entry. Multilevel logistic regression models estimated associations in each country, among urban and rural communities, and country-level odds ratios were pooled using random-effects meta-regression. Results: The analysis included 156,634 adults enrolled between 2001 and 2019, with complete data on relevant covariates. The prevalence of reporting ⩾4 symptoms of feeling sad, blue, or depressed for two weeks or longer in the past year was 13.3% in urban communities (from 0.7% in Bangladesh to 44.2% in Palestine), and 9.7% in rural communities (from 0.6% in Philippines to 32.3% in Zimbabwe). Annual average PM₂.₅ concentrations varied widely in urban areas, from 9.6 µg/m³ in Canada to 70.1 µg/m³ in Pakistan, with a similar range in rural areas. In adjusted models, the pooled association was moderately strong in rural populations (OR=1.60, 95% CI: 0.97-2.64 per average increase in 10 µg/m³ of ambient PM₂.₅ in a given country, 𝐼²=78.6%), and weaker in urban populations (OR=1.08, 95% CI: 0.69-1.70, 𝐼²=94.9%). Effect estimates were highly variable between countries, but statistically non-significant across the entire cohort. Conclusions: These findings suggest that the relationship between long-term ambient PM₂.₅ exposure and depressive symptoms is highly context-dependent, and further location-specific studies are warranted to address this heterogeneity. Given the well-documented health risks of ambient PM₂.₅, efforts to reduce air pollution levels could provide dual benefits for both physical and mental health.
Toward Generating More Diagnostic Features from Photoplethysmogram Waveforms
Creators: name: Elgendi, Mohamed
name: Liang, Yongbo
name: Ward, Rabab Kreidieh
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Photoplethysmogram (PPG) signals collected using a pulse oximeter are increasingly being used for screening and diagnosis purposes. Because of the non-invasive, cost-effective, and easy-to-use nature of the pulse oximeter, clinicians and biomedical engineers are investigating how PPG signals can help in the management of many medical conditions, especially for global health application. The study of PPG signal analysis is relatively new compared to research in electrocardiogram signals, for instance; however, we anticipate that in the near future blood pressure, cardiac output, and other clinical parameters will be measured from wearable devices that collect PPG signals, based on the signal’s vast potential. This article attempts to organize and standardize the names of PPG waveforms to ensure consistent terminologies, thereby helping the rapid developments in this research area, decreasing the disconnect within and among different disciplines, and increasing the number of features generated from PPG waveforms.
Dynamic call admission control under partial separation in ATM networks.
Creators: name: Liu, Hui.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Engineering, Electronics and Electrical.

description: A dynamic call admission control scheme is proposed for ATM networks to support multiple Quality of Service (QoS) requirements. The scheme is based on the notion of partial separation. It divides the overall traffic flows into classes, within which each traffic source has similar QoS requirements, but may have different traffic characteristics, and the bandwidth of a link is dynamically allocated among the classes. A dynamic bandwidth allocation strategy is introduced. It achieves the goal of bandwidth allocation by optimizing a cost function defined as an estimate of the overall cell loss rate that would be generated by the total offered load. It is dynamic in the sense that the bandwidth allocation is adjusted each time when a connection requires for an acceptance or a leave. While optimizing the overall cell loss rate across classes, cell level constraint is satisfied for each class by deploying the cell loss rate estimate algorithm, proposed by H. Esaki in Connection Admission Control in ATM Networks. A simulation program is developed to validate the accuracy of the algorithm. Extensive numerical and simulation results are presented. Numerical search method is deployed to locate the optimal bandwidth assignment set. Numerical results are presented to evaluate the efficiency and adequacy of the CAC scheme.
Central Nervous Activity upon Systemic Salicylate Application in Animals with Kanamycin-Induced Hearing Loss - A Manganese-Enhanced MRI (MEMRI) Study
Creators: name: Gröschel, Moritz
name: Götze, Romy
name: Müller, Susanne
name: Ernst, Arne
name: Basta, Dietmar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: This study investigated the effect of systemic salicylate on central auditory and non-auditory structures in mice. Since cochlear hair cells are known to be one major target of salicylate, cochlear effects were reduced by using kanamycin to remove or impair hair cells. Neuronal brain activity was measured using the non-invasive manganese-enhanced magnetic resonance imaging technique. For all brain structures investigated, calcium-related neuronal activity was increased following systemic application of a sodium salicylate solution: probably due to neuronal hyperactivity. In addition, it was shown that the central effect of salicylate was not limited to the auditory system. A general alteration of calcium-related activity was indicated by an increase in manganese accumulation in the preoptic area of the anterior hypothalamus, as well as in the amygdala. The present data suggest that salicylate-induced activity changes in the auditory system differ from those shown in studies of noise trauma. Since salicylate action is reversible, central pharmacological effects of salicylate compared to those of (permanent) noise-induced hearing impairment and tinnitus might induce different pathophysiologies. These should therefore, be treated as different causes with the same symptoms.
Systems analysis of decision support systems for water resource users and planners in Eastern Ontario.
Creators: name: Wilson, David John.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Environmental.

description: Following up on a body of research commencing with the Wastewater Allocation Study of the South Nation River [1992] in Eastern Ontario, the problems facing watershed managers are assessed. Following a systems engineering methodology, the WMDSS requirements are decomposed and ranked in order of priority. This yields a ranking for development of tool and information functional groups to support the following assessment types: surface water quality, surface levels and flows, integration, groundwater flows/levels, rainfall/runoff modelling and time series analysis. Functional analysis then provides the architecture and data flows necessary to meet system requirements: primary sub-systems for management of the database, knowledge base, model base, graphical user interface and output reporting are characterised. The current state of the science of watershed management is assessed with a view towards meeting the identified system functionality. With a comprehensive object-oriented analysis and design (OOA/D), the framework necessary for production of a contemporary Watershed Management Decision Support System (WMDSS) is outlined and assessed in light of current tools in use today. (Abstract shortened by UMI.)
Identification and characterization of the type 1 diabetes-related wheat storage globulin WP5212
Creators: name: MacFarlane, Amanda J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Chemistry, Biochemistry.
subject: Health Sciences, Pathology.
subject: Health Sciences, Immunology.

description: Type 1 diabetes (T1D) affects approximately 200,000 Canadians and is increasing at a rate of about 3.0% per year. The development of autoimmune diabetes requires genetic susceptibility and is influenced by environmental agents. Diets in which wheat protein is the sole amino acid source are associated with high diabetes frequency in diabetes-prone BioBreeding (BBdp) rats and non-obese diabetic (NOD) mice, two models of spontaneous autoimmune diabetes. We hypothesized that an abnormal immune response to wheat, as indicated by circulating IgG antibodies, could be used to identify T1D-related wheat proteins. Similar methods have been used to identify the diabetes-related autoantigens. A wheat cDNA expression library was immunoscreened with pooled IgG antibodies from wheat gluten-fed diabetic BBdp rats. Initially, three clones were isolated. When the proteins were screened with sera from individual rats at varying risk of disease, antibody reactivity to clone WP5212, a wheat storage globulin, was strongest in diabetic rats. This antibody reactivity was not only associated with disease but also closely correlated with islet damage. Additional studies revealed that WP5212 antibodies were linked to diabetes in NOD mice and, remarkably, in human T1D patients. Furthermore, patients with both T1D and the wheat sensitive enteropathy, celiac disease (CD), displayed high WP5212 antibody reactivity, possibly representing a marker of the predisposition of T1D patients to develop CD. WP5212 shared homology with a number of dietary proteins and allergens, suggesting that diabetes-promoting structures could exist in other food plants and that immunomodulatory molecules could interact with the immune system by a common mechanism. WP5212 also shared homology with self proteins, which could act as a means for the initiation or promotion of autoimmunity. WP5212 is the first candidate dietary wheat protein implicated in the development of diabetes. Thus, screening a cDNA expression library provides a novel approach that permits the identification of environmental antigens involved in autoimmune diseases. The evidence suggests that WP5212 is strongly antigenic in three separate species that develop spontaneous diabetes. The molecular identity of this immune-targeted dietary wheat protein will help elucidate the pathogenic mechanisms by which wheat-related diabetes occurs.
title: Protocolos de angioTC en patología aórtica: técnicas de supervivencia para el residente en apuros.
Creators: name: Marỉn Crespo, Patricia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Haemodynamics / Flow dynamics
subject: Artifacts
subject: Aneurysms
subject: Stents
subject: Technical aspects
subject: Contrast agent-intravenous
subject: CT-Angiography
subject: Image manipulation / Reconstruction
subject: Vascular
subject: Arteries / Aorta

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Se enseñará al residente de rayos a sobrevivir en las siguientes situaciones: síndrome aórtico agudo (SAA),
diagnóstico y seguimiento del aneurisma de aorta torácica-abdominal y estudio de aorta tratada mediante endoprótesis (EVAR y TVAR), 1-...
Gemini/GMOS spectroscopy of the spheroid and globular cluster system of NGC 3923
Creators: name: Norris, Mark A.
name: Sharples, Ray M.
name: Bridges, Terry
name: Gebhardt, Karl
name: Forbes, Duncan
name: Proctor, Robert N.
name: Raul Faifer, Favio
name: Carlos Forte, Juan
name: Beasley, Michael
name: Zepf, Stephen E.
name: Hanes, David A.
Publisher: name: Swinburne
Year: 2024

description: We present a technique to extract ultra-deep diffuse-light spectra from the standard multi-object spectroscopic observations used to investigate extragalactic globular cluster (GC) systems. This technique allows a clean extraction of the spectrum of the host galaxy diffuse light from the same slitlets as the GC targets. We show the utility of the method for investigating the kinematics and stellar populations of galaxies at radii much greater than usually probed in longslit studies, at no additional expense in terms of telescope time. To demonstrate this technique, we present Gemini South Multi-Object Spectrograph (GMOS) spectroscopy of 29 GCs associated with the elliptical galaxy NGC 3923. We compare the measured stellar population parameters of the GC system with those of the spheroid of NGC 3923 at the same projected radii, and find the GCs to have old ages >10 Gyr, [α/Fe]∼ 0.3 and a range of metallicities running from [Z/H]=−1.8 to +0.35. The diffuse light of the galaxy is found to have ages, metallicities and [α/Fe] abundance ratios indistinguishable from those of the red GCs.
Assessing the cause of irreversible permeate flux decline of reverse osmosis membranes during the treatment of wastewater.
Creators: name: Rimpelainen, Satu Julia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Engineering, Sanitary and Municipal.

description: This study was conducted to determine causes of irreversible permeate flux declines observed during the treatment of waste water. The resistance of reverse osmosis membranes to fouling during the processing of waste water at various crossflow velocities is evaluated. Tests were performed with a three weight percent NaCl solution and with batches of a waste stream that is treated at AECL's Chalk River Laboratories. With the NaCl tests, the mass transfer coefficient of NaCl was determined for crossflows ranging from 30 L/min to 60 L/min. Using the mass transfer coefficients calculated with the NaCl tests, the permeate flux was predicted for the waste stream based strictly on osmotic pressure considerations. A three-step cleaning procedure was developed to restore the permeate flux of the fouled reverse osmosis membranes to an acceptable level of 1 L/min. This level is required in order to prevent accumulation within the process. Tests were also conducted to determine if the three-step cleaning procedure had degraded the integrity of the membrane. (Abstract shortened by UMI.)
Inferring RNA sequence preferences for poorly studied RNA-binding proteins based on co-evolution
Creators: name: Yang, Shu
name: Wang, Junwen
name: Ng, Raymond T.
Publisher: name: BioMed Central
Year: 2018

description: Background: Characterizing the binding preference of RNA-binding proteins (RBP) is essential for us to understand the interaction between an RBP and its RNA targets, and to decipher the mechanism of post-transcriptional regulation. Experimental methods have been used to generate protein-RNA binding data for a number of RBPs in vivo and in vitro. Utilizing the binding data, a couple of computational methods have been developed to detect the RNA sequence or structure preferences of the RBPs. However, the majority of RBPs have not yet been experimentally characterized and lack RNA binding data. For these poorly studied RBPs, the identification of their binding preferences cannot be performed by most existing computational methods because the experimental binding data are prerequisite to these methods. Results: Here we propose a new method based on co-evolution to predict the sequence preferences for the poorly studied RBPs, waiving the requirement of their binding data. First, we demonstrate the co-evolutionary relationship between RBPs and their RNA partners. We then present a K-nearest neighbors (KNN) based algorithm to infer the sequence preference of an RBP using only the preference information from its homologous RBPs. By benchmarking against several in vitro and in vivo datasets, our proposed method outperforms the existing alternative which uses the closest neighbor’s preference on all the datasets. Moreover, it shows comparable performance with two state-of-the-art methods that require the presence of the experimental binding data. Finally, we demonstrate the usage of this method to infer sequence preferences for novel proteins which have no binding preference information available. Conclusion: For a poorly studied RBP, the current methods used to determine its binding preference need experimental data, which is expensive and time consuming. Therefore, determining RBP’s preference is not practical in many situations. This study provides an economic solution to infer the sequence preference of such protein based on the co-evolution. The source codes and related datasets are available at https://github.com/syang11/KNN .
The DEEP2 Galaxy Redshift Survey: The red sequence AGN fraction and its environment and redshift dependence
Creators: name: Montero-Dorta, A. D.
name: Croton, Darren
name: Yan, Renbin
name: Cooper, M. C.
name: Newman, Jeffrey A.
name: Georgakakis, Antonis
name: Prada, Francisco
name: Davis, M.
name: Nandra, Kirpal
name: Coil, Alison L.
Publisher: name: Swinburne
Year: 2024

description: We measure the dependence of the active galactic nuclei (AGN) fraction on local environment at z~ 1, using spectroscopic data taken from the DEEP2 Galaxy Redshift Survey, and Chandra X-ray data from the All-Wavelength Extended Groth Strip International Survey (AEGIS). To provide a clean sample of AGN, we restrict our analysis to the red sequence population; this also reduces additional colour-environment correlations. We find evidence that high-redshift LINERs in DEEP2 tend to favour higher density environments relative to the red population from which they are drawn. In contrast, Seyferts and X-ray selected AGN at z~ 1 show little (or no) environmental dependencies within the same underlying population. We compare these results with a sample of local AGN drawn from the Sloan Digital Sky Survey (SDSS). Contrary to the high-redshift behaviour, we find that both LINERs and Seyferts in the SDSS show a slowly declining red sequence AGN fraction towards high-density environments. Interestingly, at z~ 1 red sequence Seyferts and LINERs are approximately equally abundant. By z~ 0, however, the red Seyfert population has declined relative to the LINER population by over a factor of ~4.5. We speculate on possible interpretations of our results.
The Functional Characterization of Wdr68 Regulation of Pax7 Activity in Myogenesis
Creators: name: Jackson, Anna Francina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: In response to tissue trauma, quiescent satellite cells in adult skeletal muscle undergo proliferative activation and migrate to the site of injury where they differentiate and fuse to mend and replace damaged myofibers. The tightly synchronized expression of myogenic regulatory factors plays a critical role in orchestrating the regenerative process. In recent studies, we identified the transcription factor Pax7 as able to recruit the Wdr5-Ash2L-MLL2 histone methyltransferase complex to the -57.5kb Myf5 enhancer and to activate Myf5 transcription. We also identified Wdr68 as a putative Pax7 binding protein. Wdr68 is a scaffold protein thought to integrate Shh signaling but about which very little is known. Therefore, we set out to characterize a role for Wdr68 with Pax7 in early myogenesis. The interaction of endogenous Pax7 and exogenous Wdr68 was validated by reciprocal co-immunoprecipitation and western blot analysis. Manipulation of Wdr68 levels in primary myoblasts followed by real-time PCR analysis of Pax7 target genes suggests that Wdr68 acts as a negative regulator of Pax7. It has been determined by ChIP experiments that Wdr68 does not bind chromatin at some known genomic Pax7 binding sites. In addition, Wdr68 appears not to function by regulating Pax7 nuclear localization. These experiments provide new insights into the molecular control of Pax7 function during regenerative myogenesis and emphasize its complexity.
Glacier-ocean interactions in the Canadian Arctic and implications for freshwater dynamics
Creators: name: Parrott, Claire M.
Publisher: name: University of British Columbia
Year: 2025

description: The Arctic is facing rapid environmental change including increased melt of snow, glaciers, and sea ice. Glacier melt entering the ocean can alter regional freshwater dynamics by affecting freshwater content and stratification. Furthermore, tidewater glaciers can influence the coastal marine environment in important ways, such as enhancing biological productivity by increasing nutrient delivery to surface waters through subglacial plume-induced upwelling. The Canadian Arctic Archipelago (CAA) is a critical Arctic Ocean freshwater export pathway and the third most glacierized region in the world. However, the influence of tidewater glaciers on the regional-scale freshwater dynamics and the coastal ocean environment is not well characterized across this region. The goal of this thesis is to examine the influence of glaciers on a regional-scale freshwater budget, and on coastal water property variability in Jones Sound, a glacier-rich export pathway in the CAA and home to the Inuit community of Ausuittuq. To assess the role of glaciers in the changing freshwater system of Jones Sound, a freshwater budget is constructed using output from 2005–2022 from a coupled sea ice-ocean model; over the study period freshwater accumulates. The dominant freshwater sources and sink also change: the dominant source is initially oceanic freshwater import but changes to local sources of runoff, precipitation, and notably glacier melt; meanwhile the freshwater sink, sea ice refreeze, decreases. Glacier influence on the coastal marine environment is studied using in-situ physical and chemical water column observations collected across Jones Sound over 4 years in collaboration with the community of Ausuittuq. It is shown that sites with tidewater glaciers have enhanced nutrient concentrations above the nutricline, as well as increased turbidity in the upper water column. Freshwater and stratification are not systematically impacted by tidewater glacier presence, but are affected by the site’s coastline. This study demonstrates the increasingly prominent role of glaciers in freshwater dynamics in Jones Sound, and an important influence of tidewater glaciers on coastal ocean biogeochemistry. These findings aid in understanding ongoing change in the CAA, and may inform the community of Ausuittuq, who use Jones Sound for traditional practices and economic benefit, on best ways to adapt.
Bose-Einstein condensates on magnetic film microstructures
Creators: name: Singh, M.
name: Whitlock, S.
name: Anderson, R.
name: Ghanbari, Saeed
name: Hall, Brenton
name: Volk, M.
name: Akoulchine, Alexandre
name: McLean, Russell
name: Sidorov, Andrei
name: Hannaford, Peter
Publisher: name: Swinburne
Year: 2024

description: We report on recent experiments with BECs and ultracold atoms in magnetic microtraps created by magnetic film microstructures on an atom chip. We describe the use of RF spectroscopy plus absorption imaging of ultracold atoms as a sensitive high resolution technique to map the magnetic field topology of the magnetic film. We find that the distribution of condensate atoms between the wells of an asymmetric double-well potential on the magnetic film can provide a highly sensitive technique for determining potential gradients, such as gravitational gradients, using an atom chip. Finally, we report on the use of periodic magnetic film microstructures to generate a magnetic lattice for manipulating BECs and ultracold atoms.
Examining the cognitive effects of a special extract of Bacopa monniera (CDRI 08: KeenMind): A review of ten years of research at Swinburne University
Creators: name: Stough, Con
name: Scholey, Andrew
name: Cropley, Vanessa
name: Wesnes, Keith A.
name: Zangara, A.
name: Pase, Matthew
name: Savage, Karen
name: Nolidin, Karen
name: Lomas, Justine
name: Downey, Luke
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 520201
subject: Behavioural genetics
classificationCode: 520202
subject: Behavioural neuroscience
classificationCode: 520203
subject: Cognitive neuroscience
classificationCode: 520205
subject: Psychopharmacology
classificationCode: 520206
subject: Psychophysiology
classificationCode: 520207
subject: Social and affective neuroscience
classificationCode: 520301
subject: Clinical neuropsychology
classificationCode: 520401
subject: Cognition
classificationCode: 520403
subject: Learning, motivation and emotion

description: Bacopa monniera (EBm), an Indian aquatic herb, has been used in traditional Ayurvedic medicine for centuries for indications related to memory and inflammation. More recently specific extracts of EBm have emerged that have been subjected to rigorous in vitro, animal and now human clinical trials. In this paper we discuss some of these studies with special reference to mechanisms and efficacy of a special extract of Bacopa (CDRI08). Studies using this extract indicate that CDRI08 has several modes of action on the human brain. Promising indications for use in humans include improving cognition in the elderly and in patients with neurodegenerative disorders.
MASE: A new data-reduction pipeline for the Magellan Echellette Spectrograph
Creators: name: Bochanski, John J.
name: Hennawi, Joseph
name: Simcoe, Robert A.
name: Prochaska, J. Xavier
name: West, Andrew A.
name: Burgasser, Adam J.
name: Burles, Scott M.
name: Bernstein, Rebecca A.
name: Williams, C.
name: Murphy, Michael
Publisher: name: Swinburne
Year: 2024

description: We introduce a data-reduction package written in Interactive Data Language (IDL) for the Magellan Echellete Spectrograph (MAGE). MAGE is a medium-resolution (R ~ 4100), cross-dispersed, optical spectrograph, with coverage from ~3000â-10000 Ã…. The MAGE Spectral Extractor (MASE) incorporates the entire image reduction and calibration process, including bias subtraction, flat fielding, wavelength calibration, sky subtraction, object extraction, and flux calibration of point sources. We include examples of the user interface and reduced spectra. We show that the wavelength calibration is sufficient to achieve ~5 km s 1 rms accuracy and relative flux calibrations better than 10%. A lightweight version of the full reduction pipeline has been included for real-time source extraction and signal-to-noise estimation at the telescope.
No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation
Creators: name: Del Gobbo, Giulia F.
name: Price, E. Magda
name: Hanna, Courtney W.
name: Robinson, Wendy P.
Publisher: name: BioMed Central
Year: 2018

description: Background: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in the MTHFR gene, 677C>T and 1298A>C, result in a thermolabile enzyme with reduced function. These variants, in both the maternal and/or fetal genes, have been associated with pregnancy complications including miscarriage, neural tube defects (NTDs), and preeclampsia (PE), perhaps due to altered capacity for DNA methylation (DNAm). In this study, we assessed the association between MTHFR 677TT and 1298CC genotypes and risk of NTDs, PE, or normotensive intrauterine growth restriction (nIUGR). Additionally, we assessed whether these high-risk genotypes are associated with altered DNAm in the placenta. Results: In 303 placentas screened for this study, we observed no significant association between the occurrence of NTDs (N = 55), PE (early-onset: N = 28, late-onset: N = 20), or nIUGR (N = 21) and placental (fetal) MTHFR 677TT or 1298CC genotypes compared to healthy pregnancies (N = 179), though a trend of increased 677TT genotype in PE/IUGR together was observed (OR 2.53, p = 0.048). DNAm was profiled in 10 high-risk 677 (677TT + 1298AA), 10 high-risk 1298 (677CC + 1298CC), and 10 reference (677CC + 1298AA) genotype placentas. Linear modeling identified no significantly differentially methylated sites between high-risk 677 or 1298 and reference placentas at a false discovery rate < 0.05 and Δβ ≥ 0.05 using the Illumina Infinium HumanMethylation450 BeadChip. Using a differentially methylated region analysis or separating cytosine-guanine dinucleotides (CpGs) by CpG density to reduce multiple comparisons also did not identify differential methylation. Additionally, there was no consistent evidence for altered methylation of repetitive DNA between high-risk and reference placentas. Conclusions: We conclude that large-scale, genome-wide disruption in DNAm does not occur in placentas with the high-risk MTHFR 677TT or 1298CC genotypes. Furthermore, there was no evidence for an association of the 1298CC genotype and only a tendency to higher 677TT in pregnancy complications of PE/IUGR. This may be due to small sample sizes or folate repletion in our Canadian population attenuating effects of the high-risk MTHFR variants. However, given our results and the conflicting results in the literature, investigations into alternative mechanisms that may explain the link between MTHFR variants and pregnancy complications, or in populations at risk of folate deficiencies, are warranted.