cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The dual roles of apoptosis-inducing factor (AIF) in neuronal life and death
Creators: name: Cheung, Eric Chi Ching
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.

description: Development of drugs to rescue neuronal cell death during acute neuronal injury such as stroke is challenging because of the multiple neuronal death pathways. Apart from the caspase pathway, neurons can also die in the absence of caspases. One of the key factors in the caspase independent pathway is the mitochondrial protein Apoptosis-inducing factor (AIF) which is released and translocated to the nucleus during cell death. In this thesis, I have first demonstrated that AIF is a critical factor in both DNA damage induced Bax dependent neuronal cell death and Bax independent excitotoxic cell death using the Hq mice that have reduced AIF expression. These results are the first to directly show the role of AIF in acute neuronal injury using both in vivo and in vitro models. Recent studies have also revealed an unexpected role of AIF in the mitochondria to maintain survival. It is therefore possible that after cell death induction, the release and subsequent loss of AIF from the mitochondria alone, but not its pro-apoptotic activity, is enough to kill the cell. To resolve this controversy, I have designed an AIF mutant construct that is mitochondrially anchored and cannot be released during cell death. The expression of this construct cannot protect cells from dying in the presence of the wildtype AIF that is able to translocate to the nucleus. This indicates that even when AIF is preserved in the mitochondria, the apoptotic activity of AIF can still kill the cell. This is the first definitive evidence that AIF is indeed pro-apoptotic during cell death, in addition to its survival role in healthy cells. AIF has suggested to be a reactive oxygen species (ROS) scavenger or to stabilize mitochondrial complex I, however, the exact role is still unclear. Using the forebrain specific AIF knockout animals, I have showed that rather than scavenging ROS, AIF may instead regulate mitochondrial structure and function through the mitochondrial fusion protein Opal. Taken together, this thesis illustrates the mechanisms of AIF in neuronal cell life and death, which are essential for the design of AIF as a drug target for acute neuronal injury such as stroke.
title: Detección de invasión del nervio óptico en el retinoblastoma mediante RM. Correlación con hallazgos histopatológicos.
Creators: name: Arias Medina, Ana
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Eyes
subject: MR

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
INTRODUCCIÓN El retinoblastoma es el tumor intraocular más frecuente en niños (1 cada 17.000 RN).
Pueden ser unilateral,
bilateral o trilateral,
es decir,
retinoblastoma bilateral asociado a un tumor neuroectodermico primitivo,
normalmente...
Surface concentration dependent structures of iodine on Pd(110)
Creators: name: Göthelid, Mats
name: Tymczenko, Michael
name: Chow, Winnie
name: Ahmadi, Sareh
name: Yu, Shun
name: Bruhn, Benjamin
name: Stoltz, Dunja
name: Von Schenck, Henrik
name: Weissenrieder, Jonas
name: Sun, Chenghua
Publisher: name: Swinburne
Year: 2024

description: We use photoelectron spectroscopy, low energy electron diffraction, scanning tunneling microscopy, and density functional theory to investigate coverage dependent iodine structures on Pd(110). At 0.5 ML (monolayer), a c(2 × 2) structure is formed with iodine occupying the four-fold hollow site. At increasing coverage, the iodine layer compresses into a quasihexagonal structure at 2/3 ML, with iodine occupying both hollow and long bridge positions. There is a substantial difference in electronic structure between these two iodine sites, with a higher electron density on the bridge bonded iodine. In addition, numerous positively charged iodine near vacancies are found along the domain walls. These different electronic structures will have an impact on the chemical properties of these iodine atoms within the layer.
Copyright Law and Performers' Rights in the Entertainment Industry: A Case Study Analysis of India and Australia
Creators: name: Bansal, Karnika
Publisher: name: Swinburne
Year: 2024

description: This thesis investigates the relationship between copyright law and performers' rights in the entertainment industries of India and Australia. It explores the current statutory relationship between the two, as well as the rights of performers versus those of authors. By conducting 19 semi-structured interviews with actors, singers, and lawyers in the music and film industries, the study highlights the inadequacies of the existing performers' rights regime and evaluates the possibility of extending property rights to performers using theoretical frameworks. The research aims to promote equitable copyright laws by expanding performers' rights, and its findings are relevant to policymakers and copyright legal scholars worldwide. of authors. The study sheds light on the perspectives of actors, singers, and lawyers in the music and film industries about the inadequacies of the existing performer rights regime and evaluate the viability of extending similar property rights to performers. The research's potential benefits to society include the expansion of performers' rights and the promotion of an equitable copyright regime.
Supplementary document for Ultralow light level color image reconstruction using high- efficiency plasmonic metasurface mosaic filters - 4446030.pdf
Creators: name: Shah, Yash
name: Connolly, Peter
name: Grant, James
name: Hao, Danni
name: Accarino, Claudio
name: Ren, Ximing
name: Kenney, Mitchell
name: Annese, valerio
name: Rew, Kirsty
name: Greener, Zoe
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplementary information
Supplementary document for Mid-infrared laser diodes epitaxially grown on on-axis (001) silicon - 4461838.pdf
Creators: name: Calvo, Marta Rio
name: Bartolomé, Laura Monge
name: Bahriz, Michael
name: Boissier, Guilhem
name: Cerutti, Laurent
name: Rodriguez, Jean-Baptiste
name: Tournie, Eric
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
The impact of chronic airway disease on symptom severity and global suffering in Canadian rhinosinusitis patients
Creators: name: Luu, Kimberly
name: Sutherland, Jason M.
name: Crump, Trafford
name: Liu, Giuping
name: Janjua, Arif
Publisher: name: BioMed Central
Year: 2018

description: Background: Patients with Chronic Rhinosinusitis (CRS) can suffer from a significant decline in their quality of life. CRS patients have a high prevalence of comorbid conditions and it is important to understand the impact of these conditions on their CRS-related quality of life. This study measures the impacts of chronic pulmonary comorbidities on quality of life, pain, and depression scores among patients with CRS awaiting Endoscopic Sinus Surgery (ESS). Methods: This study is based on cross-sectional analysis of prospectively collected patient-reported outcome data collected pre-operatively from patients waiting for ESS. Surveys were administered to patients to assess sino-nasal morbidity (SNOT-22), depression and pain. The impact of pulmonary comorbidity on SNOT-22 scores, pain and depression was measured. Results: Two hundred fifthy-three patients were included in the study, 91 with chronic pulmonary comorbidity. The mean SNOT-22 scores were significantly higher among patients with chronic pulmonary comorbidities than among patients without (37 and 48, respectively). This difference is large enough to be clinically significant. Patients with chronic pulmonary comorbidities reported slightly higher depression scores than those without. Conclusions: This study found that among CRS patients waiting for ESS, chronic pulmonary comorbidities are strongly associated with significantly higher symptom burden.
title: RM pelvica dinámica (RM defecografía). Evaluacion de los trastornos de funcion anorectal.
Creators: name: González Humara, Beatriz
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Pelvis
subject: MR
subject: Defecography

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
La RM pelvica dinamica RM defecografía es en la actualizada el método por imagen que más informacion nos da sobre la patología pelvica funcional Repasamos,
ilustramos con claves diagnóstica las principales patologías . Un conocimiento de la...
The impact of human disturbance on nest predation patterns in freshwater marshes.
Creators: name: Jobin, Benoît.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Ecology.

description: Although predation is the major factor responsible for nest losses in birds, predation patterns in marshes and adjacent uplands are poorly known. This study examined the factors affecting nest predation on marsh-nesting birds found in areas affected by different intensities of human disturbance (urban, agricultural, natural). Artificial nests simulating waterfowl and passerine nests were used for that purpose. The nests, located along transects running from the center of the marshes to the adjacent upland habitats, were set up in the months of May, June and July 1989 and 1990. Eggshell remains were used to identify the predators. Predation was higher on passerine than on waterfowl nests and on nests located in upland habitats. Deep water prevented mammalian predators from foraging deep in the marsh. Predation rates in urban and natural areas were high while nests located in agricultural areas suffered lower predation. Nest camouflage was generally unimportant in reducing chances of predation. Mammals were responsible for most of the predation events. Differences in density and/or diversity of predators in urban, agricultural and natural areas were the main causes of different predation patterns observed in the three areas.
Supplementary document for Mid-infrared laser diodes epitaxially grown on on-axis (001) silicon - 4461838.pdf
Creators: name: Calvo, Marta Rio
name: Bartolomé, Laura Monge
name: Bahriz, Michael
name: Boissier, Guilhem
name: Cerutti, Laurent
name: Rodriguez, Jean-Baptiste
name: Tournie, Eric
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplement 1
title: El paciente politraumatizado: ¿hay evidencia en lo que hacemos?
Creators: name: Valdes Solis, Pablo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Trauma
subject: Conventional radiography
subject: CT
subject: Ultrasound
subject: Emergency

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Objetivos: Revisar los conceptos de Medicina Basada en la Evidencia y Radiología Basada en la Evidencia . Valorar la aplicabilidad de la Radiología Basada en la Evidencia en el paciente politraumatizado . Discutir si las escalas de adecuación...
Cross-cultural adaptation of the delphi definitions of low back pain prevalence (German DOLBaPP)
Creators: name: Leonhardt, Marja
name: Liebers, Falk
name: Dionne, Clermont E.
name: Latza, Ute
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Assessed dimensions of low back pain (LBP) vary in prevalence studies. This may explain the heterogeneity in frequency estimates. To standardize definitions of LBP, an English consensus with 28 experts from 12 countries developed the “Delphi Definitions of Low Back Pain Prevalence” (DOLBaPP). The optimal definition and the shorter minimal definition with the related questionnaires for online, paper, and face-to-face use and telephone surveys are suitable for population-based studies. The definitions have to be adapted to different languages and cultures to provide comparable frequency estimates. The objective was to culturally adapt and pre-test the English definitions and corresponding Delphi DOLBaPP questionnaire forms into German. Methods The German DOLBaPP adaptation was conducted using the systematic approach suggested by Beaton et al. A pre-test of the Delphi DOLBaPP optimal paper questionnaire including an additional evaluation form was conducted in a sample of 121 employees (mainly office workers). In order to evaluate the comprehensibility, usability, applicability, and completeness of the adapted questionnaire, response to the questionnaire and 6 closed evaluation questions were analyzed descriptively. Qualitative methods were used for the 3 open questions of the evaluation form. Results The cultural adaptation of the DOLBaPP for a German-speaking audience required little linguistic adaptation. Conceptual equivalence was difficult for the expression “low back pain”. The expert committee considered the face validity of the pre-final version of the related Delphi DOLBaPP questionnaires as good. In the pre-test, most participants (95%) needed less than 5 minutes to fill in the optimal Delphi DOLBaPP questionnaire. They were generally positive regarding length, wording, diagram, and composition. All subjects with LBP (n = 61 out of 121 – 50.4%) answered the questions on functional limitation, sciatic pain, frequency and duration of symptoms as well as pain severity. Conclusion The results indicate that the cross-cultural German adaptation of the DOLBaPP Definitions and the corresponding questionnaires was successful. The definitions can be used in epidemiological studies to measure the prevalence of LBP. Some critical issues were raised regarding the general features of the Delphi DOLBaPP questionnaires. Future research is needed to evaluate these instruments.
title: TCE grave: correlación entre afectación del tronco cerebral y evolución clínica de los pacientes
Creators: name: Hilario Barrio, Amaya
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Neuroradiology brain

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
La detección en RM de lesiones en el tronco cerebral se ha asociado a un mal pronóstico.
Sin embargo,
esta generalización puede no ser acertada dada la buena evolución de algunos enfermos con afectación traumática del tronco.
El objetivo de...
Ökonomische Instrumente in der Luftreinhaltung
Creators: name: Oehlmann, Malte
name: Linsenmeier, Manuel
name: Klaas, Katharina
Publisher: name: My University
Year: 2019
Subjects: subject: Luftreinhaltung
subject: Luftschadstoff
subject: Luftverunreinigung
subject: Stickstoffoxid
subject: Stickstoffüberschuss
subject: Luftverschmutzung
subject: Stickoxid
subject: NOx-Minderung
subject: Umweltsteuern
subject: Wirtschaft | Konsum
subject: Luft

description: Das Forschungsvorhaben hat untersucht, welche ökonomischen Instrumente neben den in Deutschland bestehenden ordnungs- und planungsrechtlichen Instrumenten eine ökonomisch effiziente und ökologisch effektive Minderung der Luftschadstoffbelastung bewirken können. In einer Literaturstudie wurden zahlreiche ökonomische Instrumente recherchiert, die sich in Deutschland zur Minderung der Luftschadstoffbelastung einsetzen ließen. Einige Instrumente wurden dann für eine Detailanalyse ausgewählt. Der Abschlussbericht fasst die Vor- und Nachteile der analysierten Instrumente zusammen und benennt mögliche Probleme bei der Implementierung in Deutschland.
Supplementary document for Distribution of high-dimensional orbital angular momentum entanglement at telecom wavelength over 1km of optical fibre - 4462350.pdf
Creators: name: Cao, Huan
name: Gao, shecheng
name: zhang, chao
name: wang, jian
name: He, De-Yong
name: Liu, Bi-Heng
name: Wei, Zhou Zheng
name: Chen, Yujie
name: Zhaohui, Li
name: Yu, Siyuan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Material
New secondary metabolites produced by an engineered strain Streptomyces sp. XZQH13OEΔastC
Creators: name: Li, Xiaomei
name: Zhao, Shengliang
name: Lu, Chunhua
name: Shen, Yuemao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Two previously undescribed alkaloids (1–2), five known alkaloids (3–7) and five cyclodipeptides (8–12) were obtained from an ansatrienin-producing mutant strain Streptomyces sp. XZQH13OEΔ astC. Their structures were elucidated by analysis of the 1D, 2D NMR and ESI HRMS data and by comparison with the reported data. The antibacterial activities of compounds 1–12 were evaluated.
Harm reduction from the perspective of the illicit drug user: A study
Creators: name: Lishchynski, Marc A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Sociology, Criminology and Penology.

description: The notion of harm reduction has existed in many fields of study for a considerable period of time, but it has recently resurfaced primarily in the field of public health policy since the discovery of HIV and the ensuing AIDS pandemic. Harm reduction has been identified by various authorities in health care as a policy that may help reduce the spread of HIV/AIDS among users of illicit, injectable drugs. This focus on health matters makes the development of a more holistic approach towards harm reduction for users of injectable drugs difficult. This study seeks the perspective of users of illicit, injectable drugs in the greater Ottawa-Carleton region on existing harm reduction policies and practices, using a qualitative research design, and employing a literature review and interviews with users to gather the required data. The goal is to determine how they perceive the actual implementation of these policies and practices, what they would like to see implemented, and to see if there is a gap between the user's needs and what is currently being offered.
Supplementary document for Distribution of high-dimensional orbital angular momentum entanglement at telecom wavelength over 1km of optical fibre - 4462350.pdf
Creators: name: Cao, Huan
name: Gao, shecheng
name: zhang, chao
name: wang, jian
name: He, De-Yong
name: Liu, Bi-Heng
name: Wei, Zhou Zheng
name: Chen, Yujie
name: Zhaohui, Li
name: Yu, Siyuan
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplementary Material
Aktualisierte EMAS-Umwelterklärung 2013 des Umweltbundesamtes
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: EMAS Umwelterklärung
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: Die vorliegende, aktualisierte Umwelterklärung enthält die wichtigsten Umweltkennzahlen für das Jahr 2012 und fasst die wichtigsten Entwicklungen in unserem Umweltmanagement seit der Veröffentlichung der validierten ⁠EMAS⁠-Umwelterklärung 2011 zusammen.
title: Hallazgos en cardio-resonancia en pacientes con displasia arritmogénica del ventrículo derecho
Creators: name: Salinas Yeregui, Teresa
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Dysplasias
subject: MR
subject: Cardiac

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
DISPLASIA ARRITMOGÉNICA DE VENTRÍCULO DERECHO: La DAVD es una cardiomiopatía caracterizada por una serie de anomalías estructurales y funcionales secundarias a un remplazamiento progresivo del miocardio por tejido fibrograso.
Este remplazamiento...
Exploring the Impact of New and Emerging Training Technologies on the Institution of Commercial Flight Training in Australia
Creators: name: Power, Tony
Publisher: name: Swinburne
Year: 2024

description: This research investigates how the commercial flight training system in Australia is impacted by new and emerging training technologies. The research examined historically and presently how the system is shaped by technological change, how the stakeholders in the system both drive and react to this process, and implications for the future. Findings suggest that technological change creates pressure for regulatory change to allow greater use of technologies. However, this increasing use was accompanied by more extensive regulatory control. At present prescriptive regulatory control means only a major airline has the institutional legitimacy to enact substantive change in the training system.
Commercial propolis extracts from Apis mellifera, Scaptotrigona bipunctata and Melipona quadrifasciata: quality control, antioxidant and antiglycemic potential
Creators: name: dos Anjos, Renata Tulio Küster Bernardo
name: Engracia, Maria Julia Gracioli
name: Etgeton, Schaina Andriela Pontarollo
name: Di Paula Silva Rodrigues, Aline Danielle
name: Silva, Anne Caroline Rodrigues
name: Krüger, Cláudia Carneiro Hecke
name: Deolindo, Carolina Turnes Pasini
name: Hoff, Rodrigo Barcellos
name: Barreto, Fabiano
name: Moresco, Karla Suzana
name: Ávila, Suelen
name: Ferreira, Sila Mary Rodrigues
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Quality control of propolis plays a pivotal role in ensuring the appropriate concentrations of active compounds, limiting unwanted substances, verifying authenticity, and adhering to regulatory standards. This study aimed to assess the identity and quality standards, the individual phenolic composition (LC-ESI-MS/MS), and the antioxidant and antiglycemic potential of commercial propolis extracts (CPEs) from Apis mellifera, Scaptotrigona bipunctata, and Melipona quadrifasciata bees. CPEs met wax content and oxidation activity criteria, surpassing minimum thresholds for total phenolic content (TPC) and flavonoid content (TFC), although stingless bee CPE did not test positive for 10% lead acetate. CPEs exhibited antioxidant and potential antiglycemic activities. Epicatechin among the thirty-three identified phenolics, showed significant correlation with TPC, DPPH, ABTS, and EC50 values of α-amylase enzyme. These promising attributes underscore the potential health benefits of commercial propolis extracts from Apis mellifera and stingless bees for further medicinal and nutritional applications.
title: Radiología de las complicaciones intra y extracraneales en el uso de derivaciones ventriculoperitoneales
Creators: name: ROMERO FLOREZ, NICOLAS
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Cerebrospinal fluid
subject: Foreign bodies
subject: Shunts
subject: Ultrasound
subject: CT
subject: MR
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Reconocer los diferentes dispositivos valvulares utilizados en las derivaciones ventrículo-peritoneales (VP) para el manejo de las hidrocefalias,
comprendiendo su función y las diferentes complicaciones asociadas a su uso. Aprender a evaluar...
Innovatives, hochpräzises Lackiersystem zur Vermeidung des Oversprays
Creators: name: Hertfelder, Walter
name: Pichler, Hans-Peter
Publisher: name: My University
Year: 2018
Subjects: Oberflächenbehandlung
Lackierung
Vorbelastung
Lack
Materialeffizienz

description: Im Rahmen des Investitionsvorhabens wurde ein hochpräzises Lackiersystem realisiert, welches unter ökologischen und funktionalen Gesichtspunkten einen maßgeblichen Entwicklungsschritt für die gesamte Branche darstellt. Aufgrund der erreichten Präzision des Lackierverfahrens und des Applikationssystems erfolgt der Lackauftrag definiert und oberflächenkonturnah. Das heißt, dass infolgedessen der benötigte Lackbedarf sowie die durch fehlerhafte Beschichtungen bedingte Ausschussware erheblich reduziert werden konnten. Darüber hinaus ermöglicht das Lackiersystem den Einsatz des InkJet-Verfahrens sowie der piezobasierten Mikrodosiertechnik, was im Bereich der Industrielackierung neue Möglichkeiten für die Realisierung von mehrfarbigen Lackierungen, Schriftzügen oder Verzierungen eröffnet. Quelle: Forschungsbericht
description: As a part of the investment plans, a highly precise coating system was implemented. This system represents a major evolution for the entire industry in terms of its ecological and functional aspects. Due to the precision achieved in the coating process and by the application system, the application of the paint occurs in a precise fashion, close to the contour of the surface. This means that, as a result, the required amount of paint as well as the number of goods rejected due to faulty coating have been reduced significantly. In addition, the coating system allows for the use of inkjet processes as well as piezo-based microdosing technology, which opens up new opportunities for realizing multi-color coatings, logos and lettering or decorations in the field of industrial coating. Quelle: Forschungsbericht
Multiple effects of KCNQ1 activators on the delayed cardiac rectifier potassium channel molecular complex
Creators: name: Chan, Magnus
Publisher: name: University of British Columbia
Year: 2025

description: The cardiac delayed rectifier potassium current, IKs, formed by the co-assembly of KCNQ1 and KCNE1 subunits, plays a critical role in cardiac repolarization, acting as a reserve to adapt to higher heart rates and compensating when other repolarization currents are impaired, thereby preventing arrhythmias. Loss of function mutations in these subunits impair cardiac repolarization and are associated with inherited long QT syndrome, increasing the risk of developing a polymorphic ventricular tachycardia known as Torsades de Pointes, which can result in syncope and sudden death. Therapeutic interventions targeting the IKs channel directly to reverse the malignant effects of long QT syndrome hold significant potential but have historically been challenging due to the previously unknown binding sites for IKs activators. In this thesis, I delved into the binding mechanisms of two well-known IKs activators, mefenamic acid and 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS), and successfully elucidated their binding sites using electrophysiological and structural biology techniques. These activators potentiate the IKs current by inducing and stabilizing a conformational change in an otherwise hidden binding pocket within the S1/KCNE1/pore complex, slowing channel deactivation. Furthermore, I uncovered a dual mechanism of action for mefenamic acid on the IKs channel. At high concentrations (300 µM), mefenamic acid inhibits wild-type IKs current amplitude while preserving the delay in channel deactivation. Moreover, KCNE1 and KCNQ1 mutations in the previously elucidated binding pocket unmasked the inhibitory actions at lower drug concentrations. I propose that a lower affinity, secondary binding site near the primary binding site is responsible for inhibition, and specific mutations reveal the site. Finally, I demonstrated the graded stoichiometric effects of mefenamic acid on the wild-type IKs channel complex. The K41C mutation in KCNE1, which disrupts the primary binding site, abolishes the effects of mefenamic acid. My findings further quantified this graded loss of effect, showing that the response to mefenamic acid diminishes as the proportion of K41C-mutated subunits increases. Using mefenamic acid as an archetype for designing therapeutically useful IKs agonists, results from this thesis provide critical insights into the molecular mechanisms of IKs modulation and offers future directions for developing targeted therapies.
title: Dirty deeds and dirty bodies
title: Embodiment of the Macbeth effect is mapped topographically onto the somatosensory cortex
titleType: Subtitle
Creators: name: Schaefer, Michael
name: Rotte, Michael
name: Heinze, Hans-Jochen
name: Denke, Claudia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The theory of embodied cognition claims that knowledge is represented in modal systems derived from perception. Recent behavioral studies found evidence for this hypothesis, for example, by linking moral purity with physical cleansing (the Macbeth effect). Neurophysiological approaches provided further support by showing an involvement of sensorimotor cortices for embodied metaphors. However, the exact role of this brain region for embodied cognitions remains to be cleared. Here we demonstrate that the involvement of the sensorimotor cortex for the embodied metaphor of moral-purity is somatotopically organized. Participants enacted in scenarios where they had to perform immoral or moral acts either with their mouths or their hands. Results showed that mouthwash products were particularly desirable after lying in a voice mail and hand wash products were particularly desirable after writing a lie, thus demonstrating that the moral-purity metaphor is specific to the sensorimotor modality involved in earlier immoral behavior. FMRI results of this interaction showed activation in sensorimotor cortices during the evaluation phase that was somatotopically organized with respect to preceding lying in a voice mail (mouth-area) or in a written note (hand-area). Thus, the results provide evidence for a central role of the sensorimotor cortices for embodied metaphors.
Assessing the representativeness of physician and patient respondents to a primary care survey using administrative data
Creators: name: Li, Allanah
name: Cronin, Shawna
name: Bai, Yu Q.
name: Walker, Kevin
name: Ammi, Mehdi
name: Hogg, William
name: Wong, Sabrina T.
name: Wodchis, Walter P.
Publisher: name: BioMed Central
Year: 2018

description: Background: QUALICOPC is an international survey of primary care performance. QUALICOPC data have been used in several studies, yet the representativeness of the Canadian QUALICOPC survey is unknown, potentially limiting the generalizability of findings. This study examined the representativeness of QUALICOPC physician and patient respondents in Ontario using health administrative data. Methods: This representativeness study linked QUALICOPC physician and patient respondents in Ontario to health administrative databases at the Institute for Clinical Evaluative Sciences. Physician respondents were compared to other physicians in their practice group and all Ontario primary care physicians on demographic and practice characteristics. Patient respondents were compared to other patients rostered to their primary care physicians, patients rostered to their physicians’ practice groups, and a random sample of Ontario residents on sociodemographic characteristics, morbidity, and health care utilization. Standardized differences were calculated to compare the distribution of characteristics across cohorts. Results: QUALICOPC physician respondents included a higher proportion of younger, female physicians and Canadian medical graduates compared to other Ontario primary care physicians. A higher proportion of physician respondents practiced in Family Health Team models, compared to the provincial proportion for primary care physicians. QUALICOPC patient respondents were more likely to be older and female, with significantly higher levels of morbidity and health care utilization, compared with the other patient groups examined. However, when looking at the QUALICOPC physicians’ whole rosters, rather than just the patient survey respondents, the practice profiles were similar to those of the other physicians in their practice groups and Ontario patients in general. Conclusions: Comparisons revealed some differences in responding physicians’ demographic and practice characteristics, as well as differences in responding patients’ characteristics compared to the other patient groups tested, which may have resulted from the visit-based sampling strategy. Ontario QUALICOPC physicians had similar practice profiles as compared to non-participating physicians, providing some evidence that the participating practices are representative of other non-participating practices, and patients selected by visit-based sampling may also be representative of visiting patients in other practices. Those using QUALICOPC data should understand this limited representativeness when generalizing results, and consider the potential for bias in their analyses.
Methodische Grundlagen für sozio-ökonomische Analysen sowie Folgenabschätzungen von Maßnahmen einschließlich Kosten-Nutzen Analysen nach EG-Meeresstrategie-Rahmenrichtlinie (MSRL)
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: EG-Meeresstrategie-Rahmenrichtlinie
subject: Monetäre Bewertung
subject: Ökonomischer Gewinn
subject: Monetarisierung
subject: Kosten-Nutzen-Analyse
subject: Wirtschaft | Konsum
subject: Wasser
subject: Economy | Consumption
subject: Water

description: Die Meeresstrategie-Rahmenrichtlinie (MSRL) will durch gezielte Maßnahmen bis 2021 den guten Umweltzustand in den europäischen Meeren erreichen. Dazu sind die Kosten und die Nutzen derartiger Schutzmaßnahmen zu ermitteln und abzuwägen. Die Ziele des Forschungsprojektes waren deshalb zweierlei: zum einen der Frage nachzugehen, welche ökonomischen Nutzen durch Maßnahmen zur Belastungsreduktion entstehen, und zum anderen zu untersuchen, wie die Nutzen einer Maßnahme zur Verbesserung der Meeresumwelt nach heutigem Wissensstand quantifiziert werden können. Mit der Kostenseiten befasst sich das Vorhaben nicht.
Direct current resistance measurement structure for determining line width and metal thickness variations in surface acoustic wave devices.
Creators: name: Calder, Bruce.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Electronics and Electrical.

description: SAW devices are often designed to act as bandpass filters. The electrical properties of surface acoustic wave (SAW) devices are difficult to measure prior to being wirebonded into packages. Matching difference in SAW devices cause difficulties in obtaining accurate measurement of the centre frequency of the bandpass reponse of unpackaged SAW devices. The variation in centre frequency of SAW devices due to fabrication variation is dependent on the variation of the width and thickness of the metal fingers of the SAW device. The width and thickness of aluminum lines of a surface acoustic wave device can be determined by direct current resistance measurement of a single thickness, two part aluminum structure. The first component is based on the van der Pauw sheet resistance structure. The second component is a direct current line width measurement structure. The direct current resistance structure presented here provides a method for determining the width and thickness of the fingers of the interdigital transducer of a SAW device. From the width and thickness information, the centre frequency and bandwidth of a SAW device can be extrapolated. Both direct current and radio frequency measurements can be made rapidly and reproducibly with the aid of computer automation. An automated system for each type of measurement (direct current and radio frequency) will also be described here.
title: Ecografía endovaginal y Resonancia Magnética en Endometriosis Pélvica Profunda.
Creators: name: Blay Beltran, Jordi
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ultrasound
subject: MR
subject: Pelvis
subject: Genital / Reproductive system female
subject: Abdomen

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
La endometriosis consiste en la presencia de epitelio endometrial y estroma de localización ectópica (fuera de la cavidad uterina y el miometrio). Las localizaciones más frecuentes de la endometriosis son los ovarios y el peritoneo...
title: Hipertensión intracraneal idiopatica:  Hallazgos en TC y RM
Creators: name: Cárdenas Valencia, Cristina
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neuroradiology brain
subject: Education
subject: Head and neck
subject: MR
subject: CT
subject: Ultrasound
subject: Cerebrospinal fluid

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisión general del síndrome de hipertensión intracraneal idiopática (HII). Comentar las técnicas de imagen disponibles,
protocolo recomendado y su utilidad en el diagnóstico de la HII,
según la bibliografía actualizada. Mostrar los signos...
Determinants and Resultant Impacts of the Composition of the Boards of Australian Partners of Humanitarian International Non-Government Organisations
Creators: name: Curtis, Ian Sidney
Publisher: name: Swinburne
Year: 2024

description: This qualitative analysis of seven case-study organisations explored the factors determining the board composition of Australian partners of Humanitarian International NGOs. The desire for compliance skills, gender equality and diversity drives recruitment more than the need for sector expertise, resulting in significant governance gaps. This gap is amplified when a CEO external to the sector is hired. There is little debate as to whether the framework of super-majority independent, non-executive directors should be followed unquestioningly. The two main recommendations are that sectoral- and firm-expertise should be seen of equal importance, and that CEOs should be appointed as executive directors.
title: Nefrostomía percutánea TC-guiada con técnica de trocar: experiencia en un hospital comarcal.
Creators: name: Campos Álvarez, Carmen
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: Interventional non-vascular

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
- Describir el procedimiento de nefrostomía percutánea en un hospital comarcal,
mediante técnica de trocar guiada por TC. - Conocer sus indicaciones así como las complicaciones de esta...
Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers
Creators: name: Fuchs, Hendrik
name: Weng, Alexander
name: Gilabert-Oriol, Roger
Publisher: name: Freie Universität Berlin
Year: 2016
Subjects: subject: endosomal escape
subject: efficacy enhancers
subject: targeted toxins
subject: immunotoxins
subject: cytosolic drug delivery
subject: controlled drug release
subject: cancer treatment
subject: endocytosis
subject: 500 Naturwissenschaften und Mathematik::540 Chemie

description: The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the target cell to mediate its fatal effect. Although more than 500 targeted toxins have been investigated in the past decades, no antibody- targeted protein toxin has been approved for tumor therapeutic applications by the authorities to date. Missing efficacy can be attributed in many cases to insufficient endosomal escape and therefore subsequent lysosomal degradation of the endocytosed toxins. To overcome this drawback, many strategies have been described to weaken the membrane integrity of endosomes. This comprises the use of lysosomotropic amines, carboxylic ionophores, calcium channel antagonists, various cell-penetrating peptides of viral, bacterial, plant, animal, human and synthetic origin, other organic molecules and light-induced techniques. Although the efficacy of the targeted toxins was typically augmented in cell culture hundred or thousand fold, in exceptional cases more than million fold, the combination of several substances harbors new problems including additional side effects, loss of target specificity, difficulties to determine the therapeutic window and cell type-dependent variations. This review critically scrutinizes the chances and challenges of endosomal escape enhancers and their potential role in future developments.
Kommunen befähigen, die Herausforderungen der Anpassung an den Klimawandel systematisch anzugehen (KoBe)
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Anpassung an den Klimawandel
subject: Anpassungsfähigkeit
subject: Klimafolgenanpassung
subject: Kommunen befähigen
subject: Anpassungskapazität
subject: Schlüsselfaktoren
subject: institutionelle Faktoren
subject: Klima | Energie
subject: Climate | Energy

description: Das Forschungsvorhaben befasst sich mit der Fragestellung, welche Faktoren und Bedingungen dieAnpassungskapazitätvon Kommunen in Deutschland maßgeblich beeinflussen. Dazu wurden im Projekt empirische Befragungen mit kleineren und mittleren Kommunen wie auch eine Fachworkshopreihe mit insgesamt elf Kommunen durchgeführt. Vor diesem Hintergrund erarbeitete das Projekt Vorschläge und Unterstützungsangebote zum systematischen Aufbau von Kapazitäten zurAnpassung an den Klimawandelauf lokaler Ebene. Insbesondere die Stärkung institutioneller Faktoren, die die Fähigkeit einer Kommune beeinflussen, sich organisatorisch, prozedural und fachlich-strategisch auf neue Herausforderungen wie den Folgewirkungen des Klimawandels adäquat einzustellen, erweisen sich hier als ein wichtiger Baustein für Unterstützungsansätze.Quelle: https://www.umweltbundesamt.de
description: Das Forschungsvorhaben befasst sich mit der Fragestellung, welche Faktoren und Bedingungen die ⁠Anpassungskapazität⁠ von Kommunen in Deutschland maßgeblich beeinflussen. Dazu wurden im Projekt empirische Befragungen mit kleineren und mittleren Kommunen wie auch eine Fachworkshopreihe mit insgesamt elf Kommunen durchgeführt. Vor diesem Hintergrund erarbeitete das Projekt Vorschläge und Unterstützungsangebote zum systematischen Aufbau von Kapazitäten zur ⁠Anpassung an den Klimawandel⁠ auf lokaler Ebene. Insbesondere die Stärkung institutioneller Faktoren, die die Fähigkeit einer Kommune beeinflussen, sich organisatorisch, prozedural und fachlich-strategisch auf neue Herausforderungen wie den Folgewirkungen des Klimawandels adäquat einzustellen, erweisen sich hier als ein wichtiger Baustein für Unterstützungsansätze.
Projektstruktur und Begriffe
Creators: name: Puchan, Joerg
name: Gann, Thomas
name: Konrad, Thomas
name: Seifert, Lena
name: Nagel, Christian
name: Jaeck, David
Publisher: name: e-Journal of Practical Business Research
Year: 2012
Subjects: managementScience

description: e-Journal of Practical Business Research, Business Process Benchmarking - Band I Grundlagen, S. 1-39
The role of fibre size in highly alkaline peroxide treatment of thermomechanical pulp
Creators: name: Noki, Gloria
Publisher: name: University of British Columbia
Year: 2025

description: Peroxide brightening of thermomechanical pulp (TMP) in high alkali conditions, has been proven to develop the brightness and tensile properties of the treated pulp. Previous studies have generated a robust understanding of the effects the process has on the optical and strength properties of pulps. The rise in demand for pulps with low bulk and high tensile (better suited to board and packaging grades) has motivated this study on the contributions TMP fines (< 76 μm) make to the development of pulp properties using highly alkaline peroxide treatment (HAPT). When TMP fibres and fines are separately treated with high alkali peroxide, the peroxide reacts more rapidly with the fines, during the initial stages of the treatment. Likewise, weak acid groups are generated more rapidly in fines compared to fibres. Weak acid groups increase the surface charge, promoting fibre swelling and increasing the bonded area between adjacent fibres, which results in sheet densification. Thus, a correlation has emerged between the development of tensile strength and the generation of weak acid groups during HAPT. Due to their smaller size and larger specific surface area, fines are more accessible to the peroxide. Furthermore, fines consume peroxide more rapidly due to their higher lignin content; hence, weak acid groups form more readily on the surfaces of fines. Consequently, it is hypothesized that preferential formation of acid groups on the external surface of fines and fibres makes a significant contribution to tensile strength development. In this investigation, the effect of HAPT on pulp properties is evaluated by varying pulp compositions (fibres and fines % w/w) and treatment time. A better understanding of the correlation between acid group generation and tensile strength development during HAPT will lead to the cost-effective production of customizable pulp grades.
Lärmsituation in Deutschland unter Berücksichtigung der EU -Rahmenbedingungen zum Lärmschutz
Creators: name: Hintzsche, Matthias
Publisher: name: My University
Year: 2013

description: Zwei Drittel der Einwohner Deutschlands fühlen sich durch Lärm belästigt. Die Situation ist in anderen Ländern Europas vergleichbar.Mitder EU-Umgebungslärmrichtlinie gibt es erstmals einen gemeinsamen europäischen Ansatz zur Verminderung der Lärmbelastung der Bevölkerung. Dabei werden nach vergleichbaren Verfahren Lärmschwerpunkte durch eine umfassende, strategische Lärmkartierung ermittelt. Auf der Grundlage der Lärmkarten werden unter aktiver Mitwirkung der Öffentlichkeit Lärmaktionspläne aufgestellt. Durch die Lärmaktionsplanung konnte vielerorts die Lärmsituation verbessert werden. Dennoch sind auch in Zukunft auf allen Handlungsebenen noch große Anstrengungen erforderlich, um spürbare Verbesserungen fürdie vom Lärm betroffene Bevölkerung zu erreichen.Hierzu leistet die Lärmschutzpolitik auf europäischer Ebene einen wesentlichen Beitrag.Quelle:Informationen zur Raumentwicklung, 2013 H. 3
Do we know how psychotherapies for Bipolar Disorder work? A mixed methods investigation of active components and mechanisms of action
Creators: name: Serbetci, Duygu
Publisher: name: Swinburne
Year: 2024

description: While there is reliable evidence for the effectiveness of psychological interventions for bipolar disorder, there is a dearth of research examining how these interventions work. This project investigated two constructs central to understanding how psychotherapies work: Active components (i.e., therapy components that bring about changes in patients), and mechanisms of action (i.e., changes that happen in patients). This project involved two studies. Findings and insights from both studies contribute to the understanding of how psychotherapies work in bipolar disorder, and provides recommendations for future research such as standardised terminology and shared assessment protocols.