cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gene expression dysregulation in medication refractory depression
Creators: name: Iacob, Eli
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Clinical Psycholog

description: Depressive disorders (DD) are a leading cause of disability worldwide and display diverse symptoms including anhedonia, melancholia, decreased concentration, sleep and appetite disturbances, and suicidal thoughts and acts. Current available medications are still ineffective for more than 30% of patients, suggesting DD are multi-faceted heterogeneous disorders. Despite intense research, as yet there are no widely used biological diagnostic tests for DD. Since DD are likely a manifestation of both genetic and environmental factors, gene expression of peripheral blood leukocyte allows for a non-invasive means to evaluate trait- and state-dependent neurophysiological dysregulation. In this dissertation, we employed real-time quantitative polymerase chain reaction (qPCR) to evaluate differences between healthy controls and patients with medication-refractory depression, for a panel of candidate genes previously implicated in depression as well as novel genes implicated in related neurological disorders. Chapter 1 begins with an overview of the multiple domains involved in depression and of previous literature findings evaluating protein and gene expression. Chapter 2 describes one of our studies of gene expression of a small panel of 14 genes involved in the immune and stress response in 19 patients with medication-refractory depression, before and following symptom improvement, compared to 20 healthy controls. We found that patients displayed trait- and state-dependent dysregulation in immune cytokines IL-10 and IL-6, transcription factor NFkB1, the serotonin receptor HTR1D, GABAA modulator DBI, and the adrenergic receptors ADR2A and ADRB1. Furthermore, the dopamine receptor DRD4, the glucocorticoid receptor NR3C1, and SULT1A1 displayed acute changes following treatment, though no differences were observed Pretreatment. In Chapter 3, we describe another gene expression study with results using a larger sample size (42 patients and 38 controls) and an expanded gene panel (46 genes) that includes candidate genes from diverse biological pathways. In this study, we found upregulation of IL-10 and IL-6 as well as dysregulation in the amyloid precursor protein, neuregulin-1, and several ion channels that have roles in anxiety, pain, and fatigue. Finally, Chapter 4 summarizes results from both studies and discusses future research into promising biomarkers and novel mechanisms of depression.
The Case for Future Hadron Colliders From $B \to K^{(*)} μ^+ μ^-$ Decays
Creators: name: Allanach, B. C.
name: Gripaios, Ben
name: You, Tevong
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Recent measurements in $B \to K^{(*)} μ^+ μ^-$ decays are somewhat discrepant with Standard Model predictions. They may be harbingers of new physics at an energy scale potentially accessible to direct discovery. We estimate the sensitivity of future hadron colliders to the possible new particles that may be responsible for the anomalies: leptoquarks or $Z^\prime$s. We consider luminosity upgrades for a 14 TeV LHC, a 33 TeV LHC, and a 100 TeV $pp$ collider such as the FCC-hh. Coverage of $Z^\prime$ models is excellent: for narrow particles, with perturbative couplings that may explain the $b$-decay results for $Z^\prime$ masses up to 20 TeV, a 33 TeV 1 ab$^{-1}$ LHC is expected to cover most of the parameter space up to 8 TeV in mass, whereas the 100 TeV FCC-hh with 10 ab$^{-1}$ will cover all of it. A smaller portion of the leptoquark parameter space is covered by future colliders: for example, in a $μ^+μ^-jj$ di-leptoquark search, a 100 TeV 10 ab$^{-1}$ collider has a projected sensitivity up to leptoquark masses of 12 TeV (extendable to 21 TeV with a strong coupling for single leptoquark production), whereas leptoquark masses up to 41 TeV may in principle explain the anomalies.
description: 24 pages, 10 figures. v2: Improved discussion and references added, version submitted to JHEP
The elliptic genus of Calabi-Yau 3- and 4-folds, product formulae and generalized Kac-Moody algebras
Creators: name: Neumann, C. D. D.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper the elliptic genus for a general Calabi-Yau fourfold is derived. The recent work of Kawai calculating N=2 heterotic string one-loop threshold corrections with a Wilson line turned on is extended to a similar computation where K3 is replaced by a general Calabi-Yau 3- or 4-fold. In all cases there seems to be a generalized Kac-Moody algebra involved, whose denominator formula appears in the result.
description: 10 pages, latex, no figures
Superconductivity in unconventional metals
Creators: name: Yang, Zhilong
name: Sheng, Haohao
name: Guo, Zhaopeng
name: Zhang, Ruihan
name: Wu, Quansheng
name: Weng, Hongming
name: Fang, Zhong
name: Wang, Zhijun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Based on first-principles calculations, we demonstrate that 1H/2H-phase transition metal dichalcogenides MX2 (M=Nb,Ta; X=S,Se,Te) are unconventional metals, which have an empty-site band of $A_1'@1e$ elementary band representation at the Fermi level. The computed phonon dispersions indicate the stability of the system at high temperatures, while the presence of the soft phonon mode suggests a phase transition to the charge density wave state at low temperatures. Based on the Bardeen-Cooper-Schrieffer theory and computed electron-phonon coupling, our calculations show that the superconductivity (SC) in NbSe2 is mainly attributed to the soft phonon mode due to the half filling of the empty-site band. Accordingly, the SC has been predicted in unconventional metals TaNS monolayer and 2H-TaN2 bulk with computed $T_C=$ 10 K and 26 K respectively. These results demonstrate that the unconventional metals with partial filling of the empty-site band offer an attractive platform to search for superconductors.
description: 5 pages, 5 figures,42 references
Additional file 2: of Development of a computational promoter with highly efficient expression in tumors
Creators: name: Ho, Shu-Yi
name: Bo-Hau Chang
name: Chen-Han Chung
name: Lin, Yu-Ling
name: Cheng-Hsun Chuang
name: Pei-Jung Hsieh
name: Wei-Chih Huang
name: Nu-Man Tsai
name: Sheng-Chieh Huang
name: Yen-Ku Liu
name: Yu-Chih Lo
name: Kuang-Wen Liao
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: D5 mini-promoter primers. (PDF 101Â kb)
Genomics-Guided Personalized Medicine in the Treatment of Complex Cancer Phenotypes
Creators: name: El-Chaar, Nader N.
Publisher: name: University of Utah
Year: 2019

description: Complex cancer phenotypes are defined by their aggressive nature and lack of known or accessible therapeutic targets. My dissertation focuses on the use of a personalized medicine approach for the identification of novel therapies against two complex cancer phenotypes: Basal-like/Claudin-low breast cancer and RAS-active nonsmall cell lung cancer. RAS-active cancer is characterized by the activation of the complex signaling network of RAS, which lacks effective therapeutics capable of inhibiting the RAS protein itself or the overall pathway. Further complicating treatment is the ability of the RAS pathway to be activated independent of the presence of an activating mutation in the RAS protein. To broadly characterize pathway activation independent of RAS protein mutation, I used a gene-expression-based biomarker for RAS network activity in nonsmall cell lung cancer (NSCLC) cell lines, and identified RAS activation in both RAS-mutant and wild-type lines. I then screened for drugs whose efficacy significantly correlated to RAS network activity and showed that EGFR and MEK co-inhibition is an effective treatment personalized against RAS-active NSCLC. Finally, I demonstrated that EGFR and MEK co-inhibition induced apoptosis and blocked both EGFR-RAS-RAF-MEK-ERK and EGFR-PI3K-AKT-RPS6 nodes simultaneously in RAS-active, but not RAS-inactive NSCLC. Secondly, I identified a novel compound effective against Basal-like and Claudin-low breast cancer (BL-CL). BL-CL is a molecular subtype of breast cancer characterized by an aggressive, recurrent and nonluminal nature, epitomized by the lack of known therapeutic targets and poor patient prognosis. Using high- iv throughput screening of a marine invertebrate compound library and sequential purification of crude fractions, I identified a previously uncharacterized sulfated sterol, Topsentinol L Trisulfate (TLT), purified from a marine sponge, and showed that it inhibits AMPK and CHK1 but activates p38. Furthermore, I indentified the potential use of known AMPK and CHK1 inhibitors, alone or in combination, as an effective therapy against BL-CL. Lastly, sensitivity to TLT was projected against various human tumors by generating a gene-expression signature that predicted breast and bladder cancer as the cancer types most receptive to TLT therapy. This work describes the identification of novel treatments personalized against BL-CL and RAS-active NSCLC, providing a framework for future pre-clinical studies.
Radio mode feedback: Does relativity matter?
Creators: name: Perucho, Manel
name: Martí, José María
name: Quilis, Vicent
name: Borja-Lloret, Marina
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Radio mode feedback, associated with the propagation of powerful outflows in active galaxies, is a crucial ingredient in galaxy evolution. Extragalactic jets are well collimated and relativistic, both in terms of thermodynamics and kinematics. They generate strong shocks in the ambient medium, associated with observed hotspots, and carve cavities that are filled with the shocked jet flow. In this Letter, we compare the pressure evolution in the hotspot and the cavity generated by relativistic and classical jets. Our results show that the classical approach underestimates the cavity pressure by a factor larger or equal to 2 for a given shocked volume during the whole active phase. The tension between both approaches can only be alleviated by unrealistic jet flow densities or gigantic jet areas in the classical case. As a consequence, the efficiency of a relativistic jet heating the ambient is typically around 20% larger compared with a classical jet, and the heated volume is 2 to 10 times larger during the time evolution. This conflict translates into two substantially disparate manners, both spatially and temporal, of heating the ambient medium. These differences are expected to have relevant implications on the star formation rates of the host galaxies and their evolution.
description: Accepted for publication in MNRAS Letters
INFORMÁTICA, SEGURIDAD JURÍDICA  Y RESPONSABILIDAD DEL REGISTRADOR
Creators: name: Luis Moisset de Espanés
Publisher: name: Zenodo
Year: 2007

description:  SUMARIO: I.- Introducción. II.- El cambio social y el hombre de derecho. III.Los "ordenadores" y su función. IV.- La informática y la descentralización de los registros. V.- La "abundancia" de información. VI.- La "seguridad jurídica". VII.Seguridad jurídica, informática y decisión. VIII.- Decisión y "tópica". IX.Seguridad y Derecho Registral. X.- Responsabilidad del registrador e informática. a) Fallas del ordenador. b) Defectos del programa o "software". XI.Conclusión.
Genetic Dissection of Nonsense-Mediated mRNA Decay in Drosophila
Creators: name: Nelson, Jonathan Owen
Publisher: name: University of Utah
Year: 2019

description: The nonsense-mediated mRNA decay (NMD) pathway functions as a quality control mechanism and a feature of post-transcriptional gene regulation. NMD degrades mRNAs containing premature termination codons (PTCs) to prevent the production of potentially harmful truncated proteins, and it also destroys many error-free endogenous mRNAs to limit the expression of these genes. NMD is critical for viability in most complex organisms, highlighting the importance of this pathway; however, it is unknown which of the two NMD functions is the feature essential for viability. Understanding how NMD recognizes and degrades targets may provide insight to uncover the requirement of this pathway for viability, but the molecular mechanisms of NMD target recognition and destruction also remain unclear. Work presented in this dissertation describes genetic analysis in Drosophila to reveal the feature of the NMD pathway that is critical for viability, and refines the model describing the mechanism of NMD target degradation. We screened a collection of heterozygous deficiencies for suppression of the incomplete lethality of a hypomorphic allele of the core NMD factor Upf2. This screen identified three autosomal regions that partially suppress Upf2 mutant lethality when deleted. The endogenous NMD target Gadd45 is located within one suppressing region, and we found that elimination of Gadd45 restores viability to multiple null NMD mutants. Mekk1, a factor that acts downstream of Gadd45, resides in another suppressing region, and loss of Mekk1 also restores viability to NMD mutants. The third suppressing region contains ! ! iv! Arc2, and we found that Arc2 and the closely related Arc1 may also contribute to the lethality of Drosophila lacking NMD activity. In addition, this dissertation describes the first genetic analysis of Drosophila Smg5 mutants, and determines that Smg5 is a critical NMD factor required for viability and all NMD function. Further analysis of the first characterization of double mutants for multiple NMD factors reveals there are multiple mechanisms for NMD target degradation. These findings provide a new foundation for understanding the crucial NMD gene regulatory function and reshape the model of the NMD pathway.
A Review on Quantum Approximate Optimization Algorithm and its Variants
Creators: name: Blekos, Kostas
name: Brand, Dean
name: Ceschini, Andrea
name: Chou, Chiao-Hui
name: Li, Rui-Hao
name: Pandya, Komal
name: Summer, Alessandro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Quantum Approximate Optimization Algorithm (QAOA) is a highly promising variational quantum algorithm that aims to solve combinatorial optimization problems that are classically intractable. This comprehensive review offers an overview of the current state of QAOA, encompassing its performance analysis in diverse scenarios, its applicability across various problem instances, and considerations of hardware-specific challenges such as error susceptibility and noise resilience. Additionally, we conduct a comparative study of selected QAOA extensions and variants, while exploring future prospects and directions for the algorithm. We aim to provide insights into key questions about the algorithm, such as whether it can outperform classical algorithms and under what circumstances it should be used. Towards this goal, we offer specific practical points in a form of a short guide. Keywords: Quantum Approximate Optimization Algorithm (QAOA), Variational Quantum Algorithms (VQAs), Quantum Optimization, Combinatorial Optimization Problems, NISQ Algorithms
description: 67 pages, 9 figures, 9 tables; version 2 -- added more discussions and practical guides
On the Higher Spin Spectrum of Chern-Simons Theory coupled to Fermions in the Large Flavour Limit
Creators: name: Charan, V. Guru
name: Prakash, Shiroman
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this note, we compute the higher spin spectrum of $U(M)_k$ Chern-Simons theory coupled to $N$ flavours of fundamental fermions, in the limit $N\gg M$ with the 't Hooft coupling $λ_M =\frac{N}{k_m}$ held fixed, to order $M/N$. This theory possesses a slightly broken higher spin symmetry, and may be of interest from the perspective of higher-spin and non-supersymmetric holography. We find that anomalous dimensions of the higher spin currents achieve a finite value at strong coupling $λ_M \rightarrow \infty$, which grows with spin as $\log s$ for large $s$, as expected for gauge theories.
description: 20 pages, 8 figures, v2: added references
Genetic analysis of the ALP/Enigma family of cytoskeletal PDZ-LIM proteins in Caenorhabditis elegans
Creators: name: McKeown, Caroline Rose
Publisher: name: University of Utah
Year: 2019
Subjects: subject: Molecular biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cellular biology

description: The morphological integrity and coordinated functions of tissues depends on specialized cell junctions that serve as sites of cytoskeletal anchorage, cell-cell adhesion and communication. The ALP/Enigma family of PDZ-LIM proteins plays a role in cytoskeletal anchorage and mutations in at least one member of this family are associated with human cardiomyopathy. Here I describe the analysis of the C. elegans eat-1 gene that encodes the entire nematode ALP/Enigma protein family. Mutations in eat-1 result in pharyngeal pumping, egg-laying, and locomotory defects, phenotypes consistent with compromised muscle function. EAT-1 proteins are expressed in muscle cells, where they localize to actin anchorage and muscle attachment sites, and in epithelial cells where they localize to apical cell junctions. Consistent with this subcellular distribution, on an ultrastructural level, eat-1 mutants display defects in body wall muscle cell-cell adhesion. In the pharynx, EAT-1 is required for the accumulation of the apical junction component, AJM-1, that has an established role in junctional architecture and integrity. These data indicate that EAT-1 proteins are required for both body wall muscle cell-cell adhesion and pharyngeal apical junction integrity. The cellular defect responsible for these functional deficiencies occurs at the level of cell-cell junctions. I detect disturbances in both the molecular organization and adhesive capacity of these specialized regions of the cell surface in animals with mutations that compromise ALP/Enigma function. Thus these studies have revealed a critical and novel role for ALP/Enigma proteins for the integrity of cell junctions.
Perturbation hydrogen-atom spectrum in deformed space with minimal length
Creators: name: Stetsko, M. M.
name: Tkachuk, V. M.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study energy spectrum for hydrogen atom with deformed Heisenberg algebra leading to minimal length. We develop correct perturbation theory free of divergences. It gives a possibility to calculate analytically in the 3D case the corrections to $s$-levels of hydrogen atom caused by the minimal length. Comparing our result with experimental data from precision hydrogen spectroscopy an upper bound for the minimal length is obtained.
description: 9 pages, 3 figures
Supplementary document for Effect of Inactivating RNA Viruses by Coupled UVC and UVA LEDs Evaluated by a Viral Surrogate Commonly Used as A Genetic Vector - 5964624.pdf
Creators: name: Zhao, Yun
name: Dong, Jianfei
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplementary 1
Direct parametrisation of invariant manifolds for non-autonomous forced systems including superharmonic resonances
Creators: name: Vizzaccaro, Alessandra
name: Gobat, Giorgio
name: Frangi, Attilio
name: Touzé, Cyril
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The direct parametrisation method for invariant manifold is a model-order reduction technique that can be applied to nonlinear systems described by PDEs and discretised e.g. with a finite element procedure in order to derive efficient reduced-order models (ROMs). In nonlinear vibrations, it has already been applied to autonomous and non-autonomous problems to propose ROMs that can compute backbone and frequency-response curves of structures with geometric nonlinearity. While previous developments used a first-order expansion to cope with the non-autonomous term, this assumption is here relaxed by proposing a different treatment. The key idea is to enlarge the dimension of the parametrising coordinates with additional entries related to the forcing. A new algorithm is derived with this starting assumption and, as a key consequence, the resonance relationships appearing through the homological equations involve multiple occurrences of the forcing frequency, showing that with this new development, ROMs for systems exhibiting a superharmonic resonance, can be derived. The method is implemented and validated on academic test cases involving beams and arches. It is numerically demonstrated that the method generates efficient ROMs for problems involving 3:1 and 2:1 superharmonic resonances, as well as converged results for systems where the first-order truncation on the non-autonomous term showed a clear limitation.
The model of an anomaly detector for HiLumi LHC magnets based on Recurrent Neural Networks and adaptive quantization
Creators: name: Wielgosz, Maciej
name: Mertik, Matej
name: Skoczeń, Andrzej
name: De Matteis, Ernesto
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (cs.LG)
subject: Accelerator Physics (physics.acc-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: This paper focuses on an examination of an applicability of Recurrent Neural Network models for detecting anomalous behavior of the CERN superconducting magnets. In order to conduct the experiments, the authors designed and implemented an adaptive signal quantization algorithm and a custom GRU-based detector and developed a method for the detector parameters selection. Three different datasets were used for testing the detector. Two artificially generated datasets were used to assess the raw performance of the system whereas the 231 MB dataset composed of the signals acquired from HiLumi magnets was intended for real-life experiments and model training. Several different setups of the developed anomaly detection system were evaluated and compared with state-of-the-art OC-SVM reference model operating on the same data. The OC-SVM model was equipped with a rich set of feature extractors accounting for a range of the input signal properties. It was determined in the course of the experiments that the detector, along with its supporting design methodology, reaches F1 equal or very close to 1 for almost all test sets. Due to the profile of the data, the best_length setup of the detector turned out to perform the best among all five tested configuration schemes of the detection system. The quantization parameters have the biggest impact on the overall performance of the detector with the best values of input/output grid equal to 16 and 8, respectively. The proposed solution of the detection significantly outperformed OC-SVM-based detector in most of the cases, with much more stable performance across all the datasets.
description: Related to arXiv:1702.00833
Additional file 1 of Antimicrobial activity screening of rhizosphere soil bacteria from tomato and genome-based analysis of their antimicrobial biosynthetic potential
Creators: name: Zhou, Lu
name: Song, Chunxu
name: Li, Zhibo
name: Kuipers, Oscar P.
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Plant Biology

description: Additional file 1: Table S1. Digital DNA-DNA Hybridization (dDDH) values (in upper triangle) and Average Nucleotide Identity (ANI) values (in lower triangle) amongst different strains. Table S2. All BGCs (including known and unknown) found in each genome of selected strains.
Topological Flat Bands in Graphene Super-moiré Lattices
Creators: name: Ezzi, Mohammed M. Al
name: Hu, Junxiong
name: Ariando
name: Guinea, Francisco
name: Adam, Shaffique
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Moiré-pattern based potential engineering has become an important way to explore exotic physics in a variety of two-dimensional condensed matter systems. While these potentials have induced correlated phenomena in almost all commonly studied 2D materials, monolayer graphene has remained an exception. We demonstrate theoretically that a single layer of graphene, when placed between two bulk boron nitride crystal substrates with the appropriate twist angles can support a robust topological ultra-flat band emerging from the second hole band. This is one of the simplest platforms to design and exploit topological flat bands.
title: ADCO, Cartulaire de Cîteaux pour les possessions d'Aloxe (XVe siècle), Cart. 182 (11 H 233), 105 folios, f. 0040
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions d'Aloxe (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 182 (11 H 233), 105 folios, f. 0040, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions d'Aloxe (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 182 (11 H 233), 105 folios, f. 0040, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
title: 01_2932
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Frequency effects in Linear Discriminative Learning
Creators: name: Heitmeier, Maria
name: Chuang, Yu-Ying
name: Axen, Seth D.
name: Baayen, R. Harald
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Word frequency is a strong predictor in most lexical processing tasks. Thus, any model of word recognition needs to account for how word frequency effects arise. The Discriminative Lexicon Model (DLM; Baayen et al., 2018a, 2019) models lexical processing with linear mappings between words' forms and their meanings. So far, the mappings can either be obtained incrementally via error-driven learning, a computationally expensive process able to capture frequency effects, or in an efficient, but frequency-agnostic solution modelling the theoretical endstate of learning (EL) where all words are learned optimally. In this study we show how an efficient, yet frequency-informed mapping between form and meaning can be obtained (Frequency-informed learning; FIL). We find that FIL well approximates an incremental solution while being computationally much cheaper. FIL shows a relatively low type- and high token-accuracy, demonstrating that the model is able to process most word tokens encountered by speakers in daily life correctly. We use FIL to model reaction times in the Dutch Lexicon Project (Keuleers et al., 2010) and find that FIL predicts well the S-shaped relationship between frequency and the mean of reaction times but underestimates the variance of reaction times for low frequency words. FIL is also better able to account for priming effects in an auditory lexical decision task in Mandarin Chinese (Lee, 2007), compared to EL. Finally, we used ordered data from CHILDES (Brown, 1973; Demuth et al., 2006) to compare mappings obtained with FIL and incremental learning. The mappings are highly correlated, but with FIL some nuances based on word ordering effects are lost. Our results show how frequency effects in a learning model can be simulated efficiently, and raise questions about how to best account for low-frequency words in cognitive models.
description: 32 pages, 12 figures, 3 tables; revised version
Quantum Simulation of the First-Quantized Pauli-Fierz Hamiltonian
Creators: name: Mukhopadhyay, Priyanka
name: Stetina, Torin F.
name: Wiebe, Nathan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We provide an explicit recursive divide and conquer approach for simulating quantum dynamics and derive a discrete first quantized non-relativistic QED Hamiltonian based on the many-particle Pauli Fierz Hamiltonian. We apply this recursive divide and conquer algorithm to this Hamiltonian and compare it to a concrete simulation algorithm that uses qubitization. Our divide and conquer algorithm, using lowest order Trotterization, scales for fixed grid spacing as $\widetilde{O}(ΛN^2η^2 t^2 /ε)$ for grid size $N$, $η$ particles, simulation time $t$, field cutoff $Λ$ and error $ε$. Our qubitization algorithm scales as $\widetilde{O}(N(η+N)(η+Λ^2) t\log(1/ε)) $. This shows that even a naïve partitioning and low-order splitting formula can yield, through our divide and conquer formalism, superior scaling to qubitization for large $Λ$. We compare the relative costs of these two algorithms on systems that are relevant for applications such as the spontaneous emission of photons, and the photoionization of electrons. We observe that for different parameter regimes, one method can be favored over the other. Finally, we give new algorithmic and circuit level techniques for gate optimization including a new way of implementing a group of multi-controlled-X gates that can be used for better analysis of circuit cost.
description: Accepted in PRX Quantum
Additional file 8: of Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial
Creators: name: Presneill, Jeffrey
name: Dashiell Gantner
name: Nichol, Alistair
name: McArthur, Colin
name: Forbes, Andrew
name: Kasza, Jessica
name: Trapani, Tony
name: Murray, Lynnette
name: Bernard, Stephen
name: Cameron, Peter
name: Capellier, Gilles
name: Huet, Olivier
name: Newby, Lynette
name: Rashford, Stephen
name: Rosenfeld, Jeffrey
name: Smith, Tony
name: Stephenson, Michael
name: Varma, Dinesh
name: Vallance, Shirley
name: Walker, Tony
name: Webb, Steve
name: D. James Cooper
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: Responsible Ethics Committees. (DOCX 30Â kb)
Multiwavelength flaring activity of PKS1510-089
Creators: name: Beaklini, Pedro P. B.
name: Dominici, Tânia P.
name: Abraham, Zulema
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Aims: In this work, we analyse the multiwavelength brightness variations and flaring activity of FSRQ PKS1510-089, aiming to constrain the position of the emission sources. Methods: We report 7 mm (43 GHz) radio and R-band polarimetric observations of PKS1510-089. The radio observations were performed at the Itapetinga Radio Observatory, while the polarimetric data were obtained at the Pico dos Dias Observatory. The 7 mm observations cover the period between 2011 and 2013, while the optical polarimetric observations were made between 2009 and 2012. Results: At 7 mm, we detected a correlation between four radio and $γ$-ray flares with a delay of about 54 days between them; the higher frequency counterpart occurred first. Using optical polarimetry, we detected a large variation in polarization angle (PA) within two days associated with the beginning of a $γ$-ray flare. Complementing our data with other data obtained in the literature, we show that PA presented rotations associated with the occurrence of flares. Conclusions: Our results can be explained by a shock-in-jet model, in which a new component is formed in the compact core producing an optical and/or $γ$-ray flare, propagates along the jet, and after some time becomes optically thin and is detected as a flare at radio frequencies. The variability in the polarimetric parameters can also be reproduced; we can explain large variation in both PA and polarization degree (PD), in only one of them, or in neither, depending on the differences in PA and PD between the jet and the new component.
description: Accepted for publication in Astronomy & Astrophysics (A&A), 13 pages, 10 figures, 3 tables
Theoretical Color-Magnitude Diagrams and the Star Forming Histories of Interacting Open Multi-population Model Galaxies: Bursts and Busts
Creators: name: Valle, G.
name: Cignoni, M.
name: Shore, S. N.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: This note presents theoretical color-magnitude diagrams (CMDs) and metallicity evolution for Galactic multi-population models coupled to stellar evolution models for systems undergoing stripping and re-accretion of ambient material, called ``open'' systems in our recent studies (Valle, Galli, and Shore, 2005, A&A, 435, 551). We show that the observables for such systems, in particular those related to the recovered star formation as a function of time, are ambiguous -- systems with non-monotonic star formation rates can appear as either bursting systems or galaxies with a hiatus in the star formation.
description: 4 pages, 2 figs, uses aa.sty (2-column); Accepted for publication, A&A (2005, in press; Research Note) (pdf file only)
Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis
Creators: name: Che, Yuanmei
name: He, Jianglong
name: Li, Xiaopeng
name: Wu, Daxian
name: Zhang, Yi
name: Yuan, Guicai
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p’s influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD) was adopted to induce microglial activation and HT-22 neuron damage. Quantitative polymerase chain reaction (qRT-PCR) was taken to check miR-381-3p expression in OGD-elicited BV2 cells and HT-22 neurons. It transpired that miR-381-3p expression was lowered in BV2 cells and HT-22 cells elicited by OGD. miR-381-3p up-regulation remarkably hampered inflammatory mediator expression in BV2 cells induced by OGD and weakened HT22 neuron apoptosis. In vivo, miR-381-3p expression was abated in HI rats’ ischemic lesions, and miR-381-3p up-regulation could ameliorate inflammation and neuron apoptosis in their brain. C-C chemokine receptor type 2 (CCR2) was identified as the downstream target of miR-381-3p, and miR-381-3p suppressed the CCR2/NF-κB pathway to mitigate microglial activation and neurotoxicity. Therefore, we believed that miR-381-3p overexpression exerts anti-inflammation and anti-apoptosis in ischemic brain injury by targeting CCR2
Relaxation of monotone coupling conditions: Poisson approximation and beyond
Creators: name: Daly, Fraser
name: Johnson, Oliver
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary: 62E17, Secondary: 60E15, 60F05, 62E10

description: It is well-known that assumptions of monotonicity in size-bias couplings may be used to prove simple, yet powerful, Poisson approximation results. Here we show how these assumptions may be relaxed, establishing explicit Poisson approximation bounds (depending on the first two moments only) for random variables which satisfy an approximate version of these monotonicity conditions. These are shown to be effective for models where an underlying random variable of interest is contaminated with noise. We also give explicit Poisson approximation bounds for sums of associated or negatively associated random variables. Applications are given to epidemic models, extremes, and random sampling. Finally, we also show how similar techniques may be used to relax the assumptions needed in a Poincaré inequality and in a normal approximation result.
description: 19 pages
What is \textit{Quantum} in Probabilistic Explanations of the Sure Thing Principle Violation?
Creators: name: Mahalli, Nematollah Farhadi
name: Pusuluk, Onur
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Prisoner's Dilemma game (PDG) is one of the simple test-beds for the probabilistic nature of the human decision-making process. Behavioral experiments have been conducted on this game for decades and show a violation of the so-called \textit{sure thing principle}, a key principle in the rational theory of decision. Quantum probabilistic models can explain this violation as a second-order interference effect, which cannot be accounted for by classical probability theory. Here, we adopt the framework of generalized probabilistic theories and approach this explanation from the viewpoint of quantum information theory to identify the source of the interference. In particular, we reformulate one of the existing quantum probabilistic models using density matrix formalism and consider different amounts of classical and quantum uncertainties for one player's prediction about another player's action in PDG. This enables us to demonstrate that what makes possible the explanation of the violation is the presence of \textit{quantum coherence} in the player's initial prediction and its conversion to probabilities during the dynamics. Moreover, we discuss the role of other quantum information-theoretical quantities, such as quantum entanglement, in the decision-making process. Finally, we propose a three-choice extension of the PDG to compare the predictive powers of quantum probability theory and a more general probabilistic theory that includes it as a particular case and exhibits third-order interference.
description: 8 pages, 1 figure
Additional file 1 of A comparability study of natural and deglycosylated PD-L1 levels in lung cancer: evidence from immunohistochemical analysis
Creators: name: Mei, Jie
name: Xu, Junying
name: Yang, Xuejing
name: Gu, Dingyi
name: Zhou, Weijian
name: Wang, Huiyu
name: Liu, Chaoying
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1 Supplementary materials and methods
On the Hill Discriminant of Lamé's Differential Equation
Creators: name: Volkmer, Hans
Publisher: name: arXiv
Year: 2023
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33E10, 34D20

description: Lamé's differential equation is a linear differential equation of the second order with a periodic coefficient involving the Jacobian elliptic function ${\rm sn}$ depending on the modulus $k$, and two additional parameters $h$ and $ν$. This differential equation appears in several applications, for example, the motion of coupled particles in a periodic potential. Stability and existence of periodic solutions of Lamé's equations is determined by the value of its Hill discriminant $D(h,ν,k)$. The Hill discriminant is compared to an explicitly known quantity including explicit error bounds. This result is derived from the observation that Lamé's equation with $k=1$ can be solved by hypergeometric functions because then the elliptic function ${\rm sn}$ reduces to the hyperbolic tangent function. A connection relation between hypergeometric functions then allows the approximation of the Hill discriminant by a simple expression. In particular, one obtains an asymptotic approximation of $D(h,ν,k)$ when the modulus $k$ tends to $1$.
Creating Valid Adversarial Examples of Malware
Creators: name: Kozák, Matouš
name: Jureček, Martin
name: Stamp, Mark
name: Di Troia, Fabio
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Machine learning is becoming increasingly popular as a go-to approach for many tasks due to its world-class results. As a result, antivirus developers are incorporating machine learning models into their products. While these models improve malware detection capabilities, they also carry the disadvantage of being susceptible to adversarial attacks. Although this vulnerability has been demonstrated for many models in white-box settings, a black-box attack is more applicable in practice for the domain of malware detection. We present a generator of adversarial malware examples using reinforcement learning algorithms. The reinforcement learning agents utilize a set of functionality-preserving modifications, thus creating valid adversarial examples. Using the proximal policy optimization (PPO) algorithm, we achieved an evasion rate of 53.84% against the gradient-boosted decision tree (GBDT) model. The PPO agent previously trained against the GBDT classifier scored an evasion rate of 11.41% against the neural network-based classifier MalConv and an average evasion rate of 2.31% against top antivirus programs. Furthermore, we discovered that random application of our functionality-preserving portable executable modifications successfully evades leading antivirus engines, with an average evasion rate of 11.65%. These findings indicate that machine learning-based models used in malware detection systems are vulnerable to adversarial attacks and that better safeguards need to be taken to protect these systems.
description: 19 pages, 4 figures
Spontaneous N=2 --> N=1 local supersymmetry breaking with surviving local gauge group
Creators: name: Fre', P.
name: Girardello, L.
name: Pesando, I.
name: Trigiante, M.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Generic partial supersymmetry breaking of $N=2$ supergravity with zero vacuum energy and with surviving unbroken arbitrary gauge groups is exhibited. Specific examples are given.
description: 17 pages, 1 Textype, 2 Postscript figures
On the Near Horizon Canonical Quantum Microstates from $AdS_2/CFT_1$ and Conformal Weyl Gravity
Creators: name: Rodriguez, Leo
name: Rodriguez, Shanshan
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the full asymptotic symmetry group of black holes belonging to the same equivalence class of solutions within the Conformal Weyl Gravity formalism. We do this within an $AdS_2/CFT_1$ correspondence and by performing a Robinson-Wilczek two dimensional reduction, thus enabling the construction of an effective quantum theory of the remaining field content. The resulting energy momentum tensors generate asymptotic Virasoro algebras, to $s$-wave, with calculable central extensions. These centers in conjunction with their proper regularized lowest Virasoro eigen-modes yield the Bekenstein-Hawking black hole entropy via the statistical Cardy formula. We also analyze quantum holomorphic fluxes of the dual CFTs in the near horizon, giving rise to finite Hawking temperatures weighted by the central charges of the respective black hole spacetimes. We conclude with a discussion and outlook for future work.
description: 18 pages, no figures. Accepted version contributed to mdpi's Universe collection on open questions in black hole physics
Additional file 1: of Development of a computational promoter with highly efficient expression in tumors
Creators: name: Ho, Shu-Yi
name: Bo-Hau Chang
name: Chen-Han Chung
name: Lin, Yu-Ling
name: Cheng-Hsun Chuang
name: Pei-Jung Hsieh
name: Wei-Chih Huang
name: Nu-Man Tsai
name: Sheng-Chieh Huang
name: Yen-Ku Liu
name: Yu-Chih Lo
name: Kuang-Wen Liao
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Gene-specific primers for RT-PCR. (PDF 102Â kb)