cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Intraoperative Assessment of Surgical Lumpectomy Margins
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Approximately 20-30 percent of patients who undergo lumpectomy (removal of breast primary tumor), require re-operation because of tumor involvement at the edges of the removed tissue (tumor positive margins) indicating that some breast cancer was left within the breast itself. Lumpectomy, even with radiation, is less likely to be successful in controlling breast cancer when even small amounts of tumor cells are left at the margin of surgical removal compared to complete tumor removal. There currently is no good means to intraoperatively detect tumor at the margin of surgery. The emotional and financial cost of re-operation is great, and often mastectomy is performed for positive lumpectomy margins.

 A new beta probe, which has been shown to detect tumor cells after a FDG {imaging agent for PET (positron emission tomography imaging)} scan, may be able to identify tumor left behind at lumpectomy margins during operation. This handheld probe used during the operation could enable the surgeon to take slightly more tissue at the initial procedure, thereby avoiding positive margins and the need for subsequent surgery, thus preventing disease recurrence.

 Our study will include patients undergoing injection with FDG within 3 hours before lumpectomy. The tumor will be surgically removed and examined to determine whether the PET beta probe can detect tumor around the margins and in the breast cavity during the operation. The margins of the lumpectomy specimen will be examined and correlations made between probe detection and microscopic detection of tumor by the pathologist. In addition, sensitive molecular tumor marker tests will be performed to improve detection over current pathology. Subsequently, once the probe accuracy is demonstrated, it will be used to detect tumor during the operation and to alter the extent of surgery to avoid positive (tumor present) margins, avoid subsequent surgery, and render a patient breast tumor-free in one operation.

 Currently there is no accurate way to intraoperatively detect residual tumor cells at the surgical margins. This project is innovative in its application of a unique beta probe to identify tumor <1 mm away. Another novel aspect of the study is the applied combination of ultra-sensitive detection of cancer in the breast. Examination of lumpectomy margins with molecular assays has never been performed and could result in a more rational way to detect cancer and make decisions regarding surgical management.
Goniobranchus annulatus
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus annulatus

description: Goniobranchus annulatus (Eliot, 1904)
(Figure 6 A)
Material examined. Six specimens. MHN-YT290, ZDD, 23 Feb. 2012, 1 m, 9mm; MB28-004538, ZRP, 0 6 May 2012, 1m, 30mm, collected by S. Bruck; MB28-004549, ZRP, 20 May 2012, 2m, 30mm, collected by S. Bruck; MB28-004560, ZRP, 0 4 Jun. 2012, 1 m, 28mm, collected by A. Roseblum; MB28-004608, ZRP, 17 Aug. 2012, 1 m, 34mm, collected by A. Pouris; MB28-004681, BL, 14 May 2012, 0.5m, 14mm.
Habitats. Subtropical tidal reefs, rocky reefs and seagrass.
Occurrences. Zavora and Barra.
Geographic distribution. Indian Ocean. Introduced in the Mediterranean Sea (Mytilineou et al. 2016) Thailand (Debelius 1996), Gulf of Oman (Debelius 1996; Fatemi & Attaran-Fariman 2015), Madagascar (Gosliner et al. 2008), Tanzania (Eliot 1904c), South Africa (Gosliner 1987) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 25, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Additional file 15: of Applying systems biology to biomedical research and health care: a prĂŠcising definition of systems medicine
Creators: name: Schleidgen, Sebastian
name: Fernau, Sandra
name: Fleischer, Henrike
name: Schickhardt, Christoph
name: Ann-Kristin OĂA
name: Winkler, Eva
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Inductive derived categories from the remaining means (DOCX 37 kb)
Iaquira viridis Galileo & Martins 2001
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Iaquira
Iaquira viridis

description: 46. Iaquira viridis Galileo & Martins, 2001b: 102, fig. 5 Holotype, male
Type locality. Brazil, Espírito Santo: Linhares, 24-31.VII.1972, C. Elias
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
Goniobranchus cavae
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus cavae

description: Goniobranchus cavae (Eliot, 1904) species complex
(Figures 6 B–G)
Material examined. Eleven specimens. MB28-004546, ZRP, 20 May 2012, 2m, 26mm; MB28-004562, ZRP, 0 4 Jun. 2012; MB28-004946, ZJS, 13 Dec. 2014, 14m, 32mm; MB28-0 0 4869, VAL, 23 May 2014, 3m, 78mm; MB28-004871, VAL, 24 May 2014, 3m, 72mm; MHN-YT1266, VAL, 23 May 2014, 3m, 81mm; MB28-004873, VAL, 23 May 2014, 3m, 82mm; MB28-004924, ZRP, 19 Aug. 2014, 0.5m, 28mm. MB28-004612, ZWH, 22 Aug. 2012, 18m, 32mm; ZMBN117046, ZGWS, 13 Sep. 2013, 21m, 47mm; MB28-00 4969, ZY, 27 Feb. 2015 60m, 60mm.
Habitats. Subtropical tidal reefs, rocky reefs, seagrass and artificial reefs.
Occurrences. Zavora and Vilanculos.
Geographic distribution. Indian Ocean. Gulf of Oman (Fatemi & Attaran-Fariman 2015), Tanzania (Eliot 1904c), South Africa (Gosliner 1987; Coleman 2008), Réunion (Yonow 2012) and Mozambique (King & Fraser 2014).
Remarks. Goniobranchus cavae is highly variable in colour and at least three species have similar colour pattern: G. tennentanus, G. cavae and G. leopardus. Yonow (2012) provides morphological differences between them and gives details on G. cavae colour variations. Both morphotypes illustrated by Yonow (2012; pg. 105, plate 37 and pg.106, plate 38) were found in Mozambique. Gosliner et al. (2015) show a third morphotype of G. cavae (pag. 228, bottom right), which is also similar to one of the specimens collected by us (Fig. 6 D). Contradictorily, Gosliner et al. (2015) consider one of the morphotypes illustrated in Yonow under the name G. cavae (2012, pg. 105, plate 37) as an undescribed species (Goniobranchus sp. 19, pg. 220, bottom left). This last morphotype differs from others by the orange background instead of orange spots and is potentially a different species.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 25-26, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
“It’s just me on my own.”
Creators: name: Fuld, Jennifer Pesha
Publisher: name: No Publisher Supplied
Year: 2014

description: The concept of social support has played an important role in public health research.  Past research suggests that when individuals receive help, mental and physical stress is lessened, health outcomes are improved and even the possibility of negative health is warded off.  However, research on social support among persons who use drugs at risk for HIV is mixed in regards to the positive benefits of social support given that structural, institutional and interpersonal factors may complicate whether and how support is sought or received. To develop more effective interventions to decrease drug use and risk for HIV, it is important to better understand the role of social support in women’s lives. This dissertation explores the conditions that affect support seeking, receiving, and providing among women who use drugs.  Using qualitative life-history interview data drawn from 25 drug-involved women in New York City, 15 of women are mothers, I investigate two main areas of women’s lives:  recovery efforts – trying to become or stay drug-free and relationships with their children.  Using grounded theory, interview data were coded and analyzed using Atlas.ti.  Findings from this dissertation suggest that the social context in which individuals invoke support transactions or avoid seeking support are critical to understand.  Social support may not be available for women who continue to use drugs, particularly from family members, while in contrast, women may have no supportive relationships separate from drug-involved relationships.  Policy implications from this dissertation suggest a holistic, family-based approach may be more successful to address patterns of drug involvement and risk for HIV.  This dissertation also highlights the importance of qualitative research for the study of social support more broadly.
Effects of Cigarette Smoking & Vaping on Heart Attack
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The effects of cigarette products on heart attack (HA) size and microvascular (small blood vessel) obstruction that occurs after the large obstructed coronary artery has been reopened (no-reflow, NR) and heart function restored following heart attack are controversial. Because the magnitude of HA, NR and cardiac function are important independent predictors of long-term clinical outcome after HA, it is essential to determine whether prior exposure to cigarette smoke or electronic-cigarette vapor, with or without nicotine, has a detrimental effect on these parameters. There is a perception that e-cigarette vapors are safer than standard cigarette smoke, but there are no head-to-head comparisons in experimental HA models. Experimental studies examining the effect of standard cigarette products on HA size are controversial. However, initial recent pilot studies from our group showed that prior nicotine exposure increases the extent of NR. An increase in NR in both experimental and clinical studies is a poor prognosticator, associated with dilated and poorly functioning left ventricles, heart failure and death. Our pilot data also showed that after only 3 days of inhalation exposure to e-cigarette vapors that both systolic and diastolic blood pressure increased in an animal model, which could have a major impact on outcome during a HA. Well-established animal models of inhalation exposure and standard analyses of rodent HA and NR will be used. We will test exposure (8 weeks) to standard cigarette smoke or e-cigarette vapor, with and without nicotine, and control (air) in protocols of HA. Our objectives are to determine whether subjects exposed to e-cigarette vapors have exacerbated heart muscle cell damage, worsened microvascular injury, and/or worsened heart function in the setting of HA and to establish whether e-cigarette vapors (with and without nicotine) are safer than standard cigarette smoke.
Ischiosioma albata Martins & Galileo 1990
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Ischiosioma
Ischiosioma albata

description: 47. Ischiosioma albata Martins & Galileo, 1990: 82, fig. 44 Holotype, female
Type locality. Brazil, Espírito Santo: Santa Teresa, 15.X.1966, C.T. & C. Elias
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
Electrochemical biochip technologies for clinical sample analysis in molecular oncology
Creators: name: Bartošík, Martin
name: Moráňová, Ludmila
name: Izadi, Nasim
name: Sebuyoya, Ravery
name: Strmisková, Johana
name: Anton, Milan
name: Hrstka, Roman
Publisher: name: Zenodo
Year: 2024

description: Electrochemical (EC) detection of nucleic acids presents a promising approach for identifying these biomolecules as important cancer biomarkers. Primary benefits include affordability, rapidity, simplicity,minimal sample requirements, and potential for miniaturization, making it ideal for personalized, decentralized medicine at point-ofcare or in limited resource settings. By integrating the EC detection with with novel, PCR-free isothermal amplification techniques (IAT) like loop-mediated amplification (LAMP), rolling circle amplification (RCA), or recombinase polymerase amplification (RPA), high sensitivity and selectivity can be achieved. Application of these technologies in analyzing clinical samples from cancer patients, targeting avariety of DNA/RNA biomarkers, is demonstrated. Examples include the development of bioassays for detecting HPV oncoviruses in cervical cancer, long non-coding RNAs in prostate cancer, and DNA point mutations in BRAF or KRAS oncogenes in colorectal cancer. Consequently, EC methods coupled with IATs could serve as a valuable alternative in contemporary molecular cancer diagnostics.
Deductible insurance and the transfer of risk
Creators: name: Gaffney, Christopher
Publisher: name: No Publisher Supplied
Year: 2014

description: This thesis develops a deepened understanding of insurance and its benefits, focusing on practical aspects of insurance coverage and risk reduction. It is easy to see that the purchase of insurance increases the expected loss suffered by the insured, otherwise the insurer’s expected profit would be negative. In view of  this, we show that insurance is a variance-reducing mechanism. We first prove that the customer’s variance is less than the variance that would be experienced if insurance was not purchased, and further show that the variance of an insured loss X is equal to the sum of the covariances of the insured and insurer losses  with X.    As insurance increases the insured’s expected loss and decreases the variance, we develop a mean-variance model of insurance demand, showing how the relationship between the premium and the insured’s risk preference defines the demand for insurance. We verify Arrow’s classical (utility-based) result that the  optimal policy has full coverage above a non-zero deductible and consider the insurer’s perspective, showing that the customer can be induced to purchase the insurer’s optimal policy.    Next, we consider different forms of coinsurance. We show that the optimal straight coinsurance policy is inferior to the optimal deductible policy, while coinsurance combined with either a stop-loss limit or a deductible is equivalent to a deductible policy (in the optimum). We also show that, in each of the coinsurance cases, the optimal policy involves partial coverage if the premium exceeds the expected reimbursement.    Finally, we consider the system composed of the insured and insurer, discussing how certain customers may receive discounted premiums that are subsidized by other customers and showing how the customer and the company share in the variance. We then discuss a benefit of insurance; in the case of a single insurer and a single customer, the sum of their individual variances is less than the variance in the uninsured case, and in the case of a single insurer and multiple insured, the variance of this system is smaller than the sum of the individual uninsured variances if the insurer reimbursements are sufficiently uncorrelated.
ROLE OF CHROMATIN REMODELING IN HIV TRANSCRIPTION
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: To date, there is not a 100% effective therapy for HIV patients. Patients undergoing retroviral therapy still have roughly 1 million cells that contain the HIV virus that is silent. If therapy is stopped, these “silent’ cells can be reactivated, and these cells can be “turned on” to produce infectious virus. It would require roughly 70 years of uninterrupted therapy to get rid of these “silent” cells. We are in dire need of a more rationally effective therapy. My work intends to molecularly understand how certain factors (protein complexes) are involved in rendering these cells silent as well as being able to activate it again. The silence and activation of HIV occurs at the level of DNA and these protein complexes that govern the silence and activation of HIV DNA are DNA associated factors. My work intends to analyze how the combination of different protein complexes (all of which belong to the same family) can either silence HIV DNA or activate it depending on the biological context. Molecular insight gathered from this work will hopefully provide answers into the timely eradication of these cells that are silent in patients undergoing retroviral therapy thus giving hope for more effective therapy.
Revealing and dealing with the “messy stuff”
Creators: name: Gamble, Kedra N.
Publisher: name: No Publisher Supplied
Year: 2014

description: Excellent teaching is key to improving schools (Haycock, 1998; Darling-Hammond, 2000; Taylor & Pearson, 2002), and effective professional development can have a positive impact on teaching practice (Borko, 2004). In order for it to be effective, professional development should be grounded in what we know about adult learners (Drago-Severson, 2011). In particular, adults need learning experiences that are relevant and based on their accurately-defined needs (Knowles, Holton, & Swanson, 2005). Identifying and addressing those needs can be a complicated social endeavor that is shaped by contextual influences and competing interests. While researchers agree that conducting a systematic needs assessment can significantly impact the overall effectiveness and quality of professional development (Goldstein & Ford, 2002; Kraiger & Auginis, 2001; McGehee & Thayer, 1961), effective needs assessments are rarely conducted as part of the planning process (Clarke, 2003; Taylor, 1998). If school leaders are to see needs assessment as a critically important tool for planning PD, and if they are to be prepared to deal with the layered and diverse learner needs and interests that emerge during the process, there is a need for research that describes how others have done so. The  REVEALING AND DEALING: NEEDS ASSESSMENT AND PD  Gamble, K. (2014)  iii  purpose of this dissertation was to examine how one district used needs assessment to identify, negotiate, and plan for complex learner needs, and to examine the impact of contextual factors on the needs assessment and planning processes.  This case study used data originally collected by a K-12 school district as part of a needs assessment designed to inform its PD plan. Multiple data collection methods, including observations, document review, and interviews, were utilized by the district as part of the needs assessment and were later analyzed for this study using a systems thinking framework.  Findings showed that although the needs assessment was conducted without much incident and revealed a range of learning needs, leaders were constrained by contextual factors in their ability to address all needs. A systems thinking model for needs assessment in schools is proposed as a resource for dealing with the complexities of needs assessment and PD planning.
Goniobranchus conchyliatus
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus conchyliatus

description: Goniobranchus conchyliatus (Yonow, 1984)
(Figure 6 H)
Material examined. Nine specimens. MHN-YT11, ZWH, 24 May 2010, 16m, 20mm; MB28-00 4469, ZRP, 0 7 Feb. 2012, 2m, 17mm; MB28-004507, ZRP, 21 Feb. 2012, 1m, 27mm, collected by L. Robisson; MB28-004529, ZRP, 22 Apr. 2012, ZRP, 2, 11mm; MB28-004541, ZRP, 0 6 May 2012, 2m, 9mm, collected by S. Bruck; MB28- 0 0 4586, ZDRS, 21 Jun. 2012, 30m, 5mm; ZMBN117041, ZGWS, 25 Jun. 2013, 20m, 24mm; ZMBN117042, ZRP, 12 Jul. 2013, 0.5m, 18mm; ZMBN117043, ZGWS, 0 3 Aug. 2013, 16m, 24mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Ponta do Ouro and Zavora.
Geographic distribution. Indian Ocean. Sri Lanka (Yonow 1984), Thailand, Maldives (Gosliner et al. 2008), South Africa (Gosliner 1987) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 26, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Bertiera acutiflora A. C. Berger 2025, comb. nov.
Creators: name: Berger, Andreas
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Gentianales
Rubiaceae
Bertiera
Bertiera acutiflora

description: Bertiera acutiflora (DC.) A. C. Berger comb. nov.
Fig. 1 A – C
= Bertiera procumbens K. Schum. & K. Krause, Bot. Jahrb. Syst. 40 (3): 328. 1908, syn. nov. Type: Ecuador. Guayas, Balao: “ prope Bulao in silvis ”, January 1892, H. F. A. von Eggers 14282 (B †; lectotype, here designated: BR 0000005305544 image!; isolectotypes: US 00138193 image!, F 0068504 F fragm. image!, M 0187082 image!, M 0187083 image!).
Basionym.
Psychotria acutiflora DC., Prodr. 4: 506. 1830. ≡ Uragoga acutiflora (DC.) Kuntze, Revis. Gen. Pl. 2: 959. 1891. Type: Ecuador. Guayas, Guayaquil: “ Guayaquil ”, 1790, T. Haenke s. n. (lectotype, here designated: PR 612078 image!; isolectotype: G-DC 00667379!).
Distribution.
Ecuador: Cañar (J. H. Vargas López et al. 512, MO- 1562740 image!), Chimborazo, Esmeraldas, Guayas, Los Ríos, Manabí, Pichincha. Colombia: Island Gorgona (Andersson and Ståhl 1999).
description: Published as part of Berger, Andreas, 2025, Bertiera acutiflora (Rubiaceae, Bertiereae), a new combination based on the overlooked Psychotria acutiflora, pp. 161-166 in PhytoKeys 251 on pages 161-166, DOI: 10.3897/phytokeys.251.140272
TAʻLIM JARAYONINI TASHKIL ETISHDA INTERNET XIZMATLARIDAN FOYDALANISH
Creators: name: Odilova, Nigina
name: Nurullayeva, Malika
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: Bu maqola “Taʻlim jarayonini tashkil etishda internet xizmatlaridan foydalanish” mavzusiga bagʻishlanadi. Bugungi kunda zamonaviy texnologiyalar va internet resurslari taʻlim sohasida katta oʻzgarishlarni keltirib chiqarmoqda. Taʻlim jarayonini yanada samarali va qulay tashkil etish uchun turli xil internet xizmatlari, masalan, onlayn taʻlim platformalari, elektron darsliklar, video-konferensiyalar, va virtual laboratoriyalar keng qoʻllanilmoqda. Ushbu xizmatlar nafaqat oʻquvchilarga malaka va bilim olishda yordam beradi, balki oʻqituvchilarga oʻz pedagogik faoliyatlarini mustahkamlash, innovatsion metodlarni qoʻllash, va oʻquv materiallarini masofaviy tarzda taqdim etish imkonini yaratadi. Maqolada, internet xizmatlarining taʻlim jarayonidagi roli, uning oʻqitish va oʻrganish jarayonini qanday yaxshilashga yordam berishi va shu bilan birga, onlayn taʻlimning samaradorligi va cheklovlari haqida soʻz boradi. Shuningdek, oʻquvchilarga moʻljallangan yangi metodlar va texnologiyalarni oʻrganish, ular orqali interaktiv oʻqitish usullarini yaratish masalalari muhokama qilinadi. Maqola taʻlim tizimining rivojlanishida internet xizmatlaridan foydalanishning ahamiyatini yoritib, bugungi kunda bu texnologiyalarning taʻlim sohasida qanday rol oʻynashini koʻrsatib beradi.
Psylotoxus melanospidus Giacomel 1991
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Psylotoxus
Psylotoxus melanospidus

description: 48. Psylotoxus [sic] melanospidus Giacomel, 1991: 1
Holotype, male
Type locality. Brazil, Mato Grosso: Chapada dos Guimarães (Veu da Noiva), II.1984, F. Giacomel Current name. Psyllotoxus inexpectatus Martins & Galileo, 1990
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
On the mechanics of contact and reattachment in layered aerospace and ocular structures
Creators: name: Ge, Peinan
Publisher: name: No Publisher Supplied
Year: 2014

description: Contact and reattachment of two types of layered structures are examined. In the first part of the dissertation, a constrained patched structure subjected to uniform temperature change with edge damage is studied. Geometric nonlinearities and shear deformation are included in the mathematical model, and the effects of shear deformation are examined. The formulation is based on the calculus of variations with propagating boundaries, and yields the governing equations, boundary conditions, matching conditions and transversality condition. Results are compared with previously published results with transverse shear deformation neglected. The effects of shear deformation on the recently discovered instabilities referred to as 'sling-shot buckling' and 'buckle trapping' are demonstrated and discussed. The influence of the relative size of the detached region and of the difference between the material properties of the base plate and of the patch (in particular, the shear moduli) on the afforementioned thermo-mechanical instabilities are elucidated.   In the second part, a representative mathematical model of the eye encircled by a scleral buckle in the vicinity of the equator is developed. The effects of the buckle on the mechanical behavior of the eye, and then on closing posterior retinal detachment are both studied. Both  problems are formulated using variational methods. Closed form analytical solutions of the coupled differential equations are obtained. Results of numerical  simulations are presented and critical phenomena are unveiled. The effects of material and geometric parameters (radius, width, thickness and Young’s modulus) of the scleral buckle, as well as of the ocular pressure, on the deformation of the eye are studied. Volume changes for each case are evaluated as well. It is seen that the radius of the buckle is the dominant parameter with regard to mechanical behavior of the eye. In the final major chapter, the effect of the scleral buckle on closure and reattachment of posterior retinal detachment is studied. It is seen that as the radius of the scleral buckle reduces, the distance between the detached segment of retina and the retinal pigment epithelium decreases, thus encouraging reattachment between the two surfaces. This, evidently, has ramifications with regard to treatment of posterior retinal detachment.
Embedding smoking cessation programs into community clinics
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is a major risk factor for cardiovascular disease, chronic obstructive pulmonary disease and lung cancer. Patients seen by the health departments within the Los Angeles County Health Agency smoke more than other Californians, and there is less services to help them to stop smoking than in other health systems. In this grant, we will set up a comprehensive smoking cessation program in clinics serving Los Angeles County patients with physical and mental disorders that will offer group counseling as well as medications for smoking cessation. This study would determine the effectiveness of these clinics and, if effective, we are planning to continue them when the grant ends.
Cardiac reconstruction and analysis from high resolution CT images
Creators: name: Gao, Mingchen
Publisher: name: No Publisher Supplied
Year: 2014

description: Heart disease is a major cause of mortality worldwide. Detecting/diagnosing such diseases in their early stages is critical, and heavily depends on non-invasive imaging methods, e.g., computed tomography (CT) and magnetic resonance imaging (MRI). High resolution cardiac CT imaging technology has the resolution to reveal the complex endocardial structures of the left ventricle, such as the trabeculae and the papillary muscles. However, the development of suitable methods for the quantitative analysis of these dense data sources has lagged greatly behind the development of the imaging methods themselves. As a result, in clinical practice, and in much of the research that uses these imaging data, the quantitative analysis of cardiac function has largely been confined to the calculation of simple measures of global function, such as the ejection fraction, while local function being just qualitatively assessed. Therefore there is a large amount of the functional information potentially available from cardiac images essentially untouched.    In this thesis, for the first time, we extract clinical meaningful endocardial information of the left ventricle (LV) from high resolution CT images. The reconstructed result captured the fine detailed structures, which are extremely challenging to segment due to their delicate and complex nature in both geometry and topology. Our algorithm is especially designed to segment those structures, by calculating the potential missing topological structures. Using techniques from computational topology, e.g. persistent homology, our algorithm finds topological handles which are likely to be the true signal. Each handle is evaluated independently based in its saliency, rather than absolute intensities. The final segmentation with handles restored, leads to high quality segmentation of the complex structures. The initialized model was then deformed to other frames to reconstruct the 4D motion. Based on the reconstructed results, we study both the morphology and motion of the trabeculae and the papillary muscles. Proposed measurements have been clinically evaluated.
Trestoncideres laterialba Martins & Galileo 1990
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Trestoncideres
Trestoncideres laterialba

description: 49. Trestoncideres laterialba Martins & Galileo, 1990: 88, figs. 14, 48 Holotype, male
Type locality. Costa Rica, Cartago: Turrialba, 30.VIII.1971, V.O. Becker
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
Goniobranchus decorus
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus decorus

description: Goniobranchus decorus (Pease, 1860)
(Figure 6 I)
Material examined. One specimen. MB28-004594, ZDRS, 21 Jun. 2012, 30m, 9mm.
Habitats. Subtropical rocky reef.
Occurrences. Zavora.
Geographic distribution. Indo-west, central Pacific. Marshall Islands, Papua New Guinea, Australia, Philippines, Christmas Island (Gosliner et al. 2008), Réunion, Mayotte (Bidgrain 2005b), and Mozambique.
Remarks. This species is very similar to G. setoensis (Baba, 1938) but has purple spots on the white midline, which is not mentioned in Baba’s description (1938). Gosliner et al. (2015) cite that G. setoensis and G. decorus might (or not) represent the same specie.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 26, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Additional file 2: of Applying systems biology to biomedical research and health care: a prĂŠcising definition of systems medicine
Creators: name: Schleidgen, Sebastian
name: Fernau, Sandra
name: Fleischer, Henrike
name: Schickhardt, Christoph
name: Ann-Kristin OĂA
name: Winkler, Eva
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Annual number of papers with reference to specific disease (DOCX 15 kb)
Tobacco and Cannabis Intervention for Young Black MSM
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Young black men who have sex with men (YBMSM) are at high risk for cannabis use, and prolonged cannabis use can lead to adverse health outcomes. Young cannabis users are also at higher risk for tobacco use and eventual nicotine dependence. Additionally, mixing of tobacco with cannabis may lead to worse physical health outcomes than using cannabis alone. Mixing of tobacco and cannabis is used to enhance sexual experiences and is associated with sexual behaviors that result in increased HIV risk for YBMSM. The lack of data on patterns of tobacco and cannabis experimentation and initiation, and how these behaviors relate to sexual risk behavior, warrants more research to improve health among YBMSM. The goal of this project is to develop and test a peer-led, tobacco/nicotine and cannabis intervention tailored to YBMSM in Long Beach, California. Young men who report nonuse or infrequent use of tobacco/nicotine and cannabis will be engaged and supported to avoid initiation and transitioning into frequent users. The project involves developing individual- and community-level intervention approaches, and pilot testing the intervention by using a comparison group taken from surrounding communities similar in demographics to the intervention community.
Tulcoides pura Martins & Galileo 1990
Creators: name: Monné, Miguel A.
name: Almeida, Lucia M.
name: Oliveira, Marcio L.
name: Viana, Jéssica Herzog
name: Monné, Marcela L.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Tulcoides
Tulcoides pura

description: 50. Tulcoides pura Martins & Galileo, 1990: 64, figs. 16, 25 Holotype, male
Type locality. Brazil, Espírito Santo: Linhares (Parque Sooretama), 27.XI.1967, F. Oliveira
description: Published as part of Monné, Miguel A., Almeida, Lucia M., Oliveira, Marcio L., Viana, Jéssica Herzog & Monné, Marcela L., 2017, Checklist of Cerambycidae (Coleoptera) primary types of the Coleção Entomológica Pe. Jesus Santiago Moure, Departamento de Zoologia, Universidade Federal do Paraná, Curitiba, Paraná, Brazil, Instituto Nacional de Pesquisas da Amazônia, Amazonas, Manaus, Brazil, and of the Museu Paraense, pp. 341-365 in Zootaxa 4221 (3) on page 347, DOI: 10.5281/zenodo.250291
Goniobranchus fidelis
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus fidelis

description: Goniobranchus fidelis (Kelaart, 1858)
(Figure 6 J)
Material examined. One specimen. MB28-005039, NGF, 21 Jul. 2016, 15m, 10mm, collected by J. Wright. Habitats. Subtropical rocky reef and tropical coral reefs.
Occurrences. Ponta do Ouro and Nuarro.
Geographic distribution. Indo-west Pacific. Guam (Carlson & Hoff 2003), Japan, New Caledonia, Australia (Gosliner et al. 2008), Thailand (Mehrotra & Scott 2015), Philippines, Maldives (Gosliner et al. 2008), India (Remakrishna et al. 2010), Red Sea, Madagascar (Gosliner et al. 2008) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 26-28, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Fan, inc.
Creators: name: Gilbert, Anne
Publisher: name: No Publisher Supplied
Year: 2014

description: Interactivity has become a hyped notion in industry and academic rhetoric, often as an idealized concept in which new pathways of feedback and non-professional production have the potential to reconfigure the relationship between industry and audience. While the implications of interactivity are widely discussed, its nuances are less so; this project, therefore, articulates a more complex perspective of how interactivity structures the experience of popular media. Interactivity frames how industry and audience construct the other’s identity and their own, guides limitations and affordances for users, and provides models, restrictions, and incentives that function as protocols of behavior. In other words, interactivity is a means by which participants move beyond individual practices of production and consumption to become constituents in larger systems of meaning.    This dissertation considers four sites at which industry interests and audience goals come into contact, which provide case studies of different modes of interactivity. Television Without Pity, a user-generated online viewing community turned corporate venture, illustrates interactivity as appropriation. Co-option is the dominant narrative of interactivity, presuming industry takeover of authentic audience engagement, and it is in contrast to this somewhat reductive narrative that other modes are situated. Social TV check-in apps represent interactivity as motivator, rewards and incentives designed to promote particular user viewing behaviors; San Diego Comic-Con is interactivity as incorporation, as an increasingly broad range of attendees are interpellated into an identity of "fan"; and Pottermore, an online Harry Potter experience, introduces interactivity as constraint, meant to model appropriate levels of participation and contain transgressive fan behavior.    Through these cases, this project considers how sociality, community, work, and engagement operate through interactivity. Interactivity is not all "good," effective, or sustainable, and so these cases offer a lens through which social rewards, affective benefits, and meaning have the potential to be align with economic goals, agency, and power structures – or to fall all together out of balance. This project considers the self-valuations made by participants of interactivity, and those left out of its structures; further, it critically analyzes how those systems of value engage with one another in order to construct spaces of significance.
Synthesis and characterization of silica nanoparticles functionalized with titanocene derivatives
Creators: name: Voňka, Petr
name: Díaz-García, Diana
name: Kolářová, Tamara
name: Kubicová, Romana
name: Hrstka, Roman
name: Gómez-Ruiz, Santiago
Publisher: name: Zenodo
Year: 2024

description: Introduction: Titanocene dichloride is a well-known organometallic compound that has been tested in Phase II clinical trials in patients with metastatic breast carcinoma and advanced renal cell carcinoma. However, its activity was not very good due to the low solubility and stability of the compound in physiological medium. Therefore, the incorporation of this complex in nanoparticles could be an alternative to improve its pharmacokinetics. In this work, the design of systems based on mesoporous silica nanoparticles (MSNs) was carried out, as well as biological assays in order to compare the biological activity with the isolated complex and the influence of the chlorine atoms. Materials & Methods: MSNs were synthesized by the sol-gelmethod when tetraethyl orthosilicate was used as silica precursor and hexadecyltrimethylammonium bromide was applied as surfactant. Titanocene derivatives were covalently incorporated on the surface of MSNs through grafting reactions trough mercapto ligand. Synthesized MSNs were characterized by analytical techniques such as FTIR spectroscopy (analysis of chemical bonds), TEM analysis (morphology of MSNs), BET analysis (texturalproperties), and ICP-MS analysis (content of functionalized metal). The biological effects of synthesized MSNs were tested on MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cell lines by metabolic assay, CM-H2DCFDA assay, immunochemical analysis, and cell cycle analysis. Results: Treatment of MSNs functionalized with titanocene derivatives caused a decrease in the viability, mainly in MDA-MB-468 cells. Further, the application of synthesized MSNs introduced ROS production with influenced cell cycle progression manifested by significant increase of the sub-G1 population after treatment with functionalized MSNs. Subsequent analysis of proteins involved in key signalling pathways revealed increased level of LC3B, the protein associated with the induction of autophagy. Conclusion: MSNs were synthesized to determine how theappearance, or absence, of the chlorine atom influences the activity of titanocene derivatives and to compare the biological activity with respect to the isolated complex. The biological experiments showed that the chlorine atom is not necessary for titanocene dichloride activity, but its occurrence contributes to it. This information could be applied in future research focused on the development of novel and more efficient derivatives of titanocene dichloride supported on nanomaterials.
Space, time, and bodies: the dimensions of difference in women's cinema and continental philosophy
Creators: name: Godart, Caroline M.
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation examines the question of difference, and especially of sexual difference, in women’s cinema and continental philosophy. I analyze four movies by three of today’s most influential women filmmakers: Jane Campion (The Piano, New Zealand), Claire Denis (Beau Travail and Trouble Every Day, France), and Lucrecia Martel (La niña santa/The Holy Girl, Argentina), as well as philosophical texts by Luce Irigaray, Henri Bergson, Gilles Deleuze, and Friedrich Nietzsche. I argue that these films represent difference not only through characterization, but more essentially by emphasizing one of cinema’s core devices: space (e.g. camerawork), time (narration and editing), and bodies. Through these, the films articulate relations that go beyond hierarchies of power to portray and enact movements toward others who are acknowledged in their singularity.     Each chapter is devoted to a film, and opens with a close reading of its aesthetics with a focus on space, time, or bodies. My study of the filmic elements is set in a dialogue with analyses of the corresponding concepts in the philosophical texts. In particular, I explore the relevance for cinema studies of the concept of the interval, which is a central, yet until recently often-overlooked notion in Irigaray’s work. The interval can be defined as the force of difference as it constitutes two subjects (as opposed to a subject and an object) through the distance that both separates and brings them together. It lends itself well to cinematic analysis for it concerns bodies, and it is at once spatial and temporal. The interval itself is brought to bear on other concepts: Bergson’s duration and intuition, Deleuze’s interstice, and Nietzsche’s theory of violence. Through these theoretical and filmic networks, this dissertation sketches out new perspectives for feminist film criticism.
Goniobranchus geminus
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Chromodorididae
Goniobranchus
Goniobranchus geminus

description: Goniobranchus geminus (Rudman, 1987)
(Figure 6 K)
Material examined. Eight specimens. MB28-004711, ZT, 11 Aug. 2013, 45m, 50mm; MB28-004718, ZT, 11 Aug. 2013, 45m, 49mm; MB28-004742, ZA51, 26 Sep. 2013, 12m, 28mm; MB28-0 0 4829, 4 spcs., POA, 0 8 May 2014, 40m, 28–50mmm; MHN-YT1606, NW, 11 Apr 2016, 20m, 32mm.
Habitats. Subtropical rocky reefs and tropical coral reefs.
Occurrences. Ponta do Ouro, Zavora and Nuarro.
Geographic distribution. Indian Ocean. Thailand (Gosliner et al. 2008), Christmas Island (Rudman 1987), India (Remakrishna et al. 2010), Red Sea (Debelius 1996), Tanzania, Réunion Island (Rudman 1987), Madagascar (Gosliner et al. 2008), South Africa (Gosliner 1987) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 28, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168