cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Open hip reduction using a novel transarticular suture stabilisation technique in 24 dogs: a retrospective study of technique, outcome and complications
Creators: name: Hybki, G
name: Robbins, M
name: Kwan, T
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Medical records of a single private practice (Illinois, USA) were retrospectively reviewed to identify dogs (n=24) that had an open hip reduction with a transarticular suture stabilisation technique after presenting with a traumatic coxofemoral luxation between April 2003 and December 2018. Dogs that met the inclusion criteria were of various breeds with a median body weight of 18.1 (min 4.2, max 54.5) kg and mean age at presentation of 6.5 (min 1, max 11) years. The surgical technique, short term outcome and complications were extracted from the medical records. Long-term (>2 years) follow-up data was obtained by a telephone interview with each owner. All dogs underwent open hip reduction using a novel transarticular suture stabilisation technique. The outcome was reported by owners to be excellent in (18/24) 75% dogs with full return of limb function. Sixty-six percent (16/24) of owners reported that no lameness was observed 2 months after surgery. No minor complications were noted in this study. The hips of 6/24 (25%) dogs reluxated after surgery (defined as a major complication), which required femoral head and neck excision surgery. Open coxofemoral joint reduction using a novel transarticular suture technique is a viable surgical option to consider in dogs that present with a traumatic coxofemoral luxation.
MOESM4 of Comprehensive genomic analysis of the DUF4228 gene family in land plants and expression profiling of ATDUF4228 under abiotic stresses
Creators: name: Yang, Qi
name: Niu, Xiaocui
name: Tian, Xiaona
name: Zhang, Xiujuan
name: Cong, Jingyu
name: Wang, Ruigang
name: Zhang, Guosheng
name: Li, Guojing
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 4: Figure S2. Distribution of the DUF4228 domain in the DUF4228 proteins of plants.
title: Frequency of microsatellite instability (MSI) in upper tract urothelial carcinoma: comparison of the Bethesda panel and the Idylla MSI assay in a consecutively collected, multi-institutional cohort
Creators: name: Kullmann, Friederike
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Häufigkeit der Mikrosatelliteninstabilität (MSI) bei Urothelkarzinomen des oberen Harntrakts: Vergleich des Bethesda- Panels und des Idylla MSI-Tests in einer konsekutiv erhobenen, institutionsübergreifenden Kohorte Ziel: Das Urothelkarzinom des oberen Trakts (UTUC) ist eine seltene bösartige Erkrankung mit einer schlechten Prognose, die sporadisch auftritt oder in wenigen Fällen auf eine genetische Störung, das so genannte Lynch-Syndrom, zurückzuführen ist. In letzter Zeit hat die Untersuchung der Mikrosatelliteninstabilität (MSI) als Biomarker an Bedeutung gewonnen: MSI-Tumore werden mit einem besseren Ansprechen auf immunmodulatorische Therapien in Verbindung gebracht. Über die Prävalenz von MSI bei UTUC sind bisher nur wenige Daten bekannt. Neue Nachweismethoden, wie die Verwendung des vollautomatisierten Idylla MSI-Assays, erleichtern die Analyse größerer Anzahl von Patientenproben. Methoden: Wir untersuchten die Häufigkeit von MSI in einer institutsübergreifenden Kohorte von 243 UTUC-Proben mit Hilfe der Standardmethode (Bethesda-Panel) sowie der Immunhistochemie von Mismatch-Reparatur-Proteinen (MMR). Dieselbe Tumorkohorte wurde mit dem Idylla MSI-Assay von Biocartis erneut getestet. Ergebnisse: Mithilfe der Standardmethodik wurden 230/243 (94,7%) Tumore als mikrosatellitenstabil (MSS) und 4/243 (1,6%) Tumore als MSI erkannt. 9/243 (3,7%) Proben waren nicht auswertbar. Im Vergleich dazu identifizierte der Idylla MSI Assay vier zusätzliche Tumore als MSS, was 234/243 (96,3%) Tumoren entspricht; 4/243 (1,6%) wurden als MSI und nur 5/243 (2,1%) Fälle als ungültig eingestuft. Auf immunhistochemischer Ebene wurden die MSI-Ergebnisse der Proben mit einem Verlust an MMR-Proteinen bestätigt. Die Gesamtübereinstimmung zwischen der Standardmethode und dem Idylla MSI Assay betrug 98,35 %. Die Arbeitszeit von Probenvorbereitung bis zum Ergebnis lag beim Idylla MSI Assay bei drei Stunden und bei der Standardmethode bei zwei Tagen. Schlussfolgerungen: Unsere Daten weisen auf eine sehr niedrige Inzidenzrate von MSI-Tumoren bei Patienten mit UTUC hin. Darüber hinaus unterstreichen unsere Ergebnisse, dass der Idylla MSI Assay hinsichtlich personellen und zeitlichen Aufwands höchst effektiv ist und als alternative Methode der MSI-Analyse für UTUC eingesetzt werden kann.
Diagnosing subclinical facial eczema in cattle: does combining liver enzyme tests increase the accuracy of diagnosis?
Creators: name: Laven, R. A.
name: Yang, D. A.
name: Cuttance, E. L.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: To assess whether adding glutamate dehydrogenase (GDH) activity measurements to measurements of gamma glutamyl transferase (GGT) activity appreciably increases the accuracy of diagnosis of subclinical facial eczema (FE) in cattle. As part of a larger study on the impact of FE on productivity, GGT and GDH activities were measured in serum samples collected from 426 cattle from one dairy farm in the Taranaki region in April 2018. Bayesian latent class analysis was then used to estimate herd prevalence of subclinical FE as well as the specificity and sensitivity of the activity in serum of GGT or GDH alone, and of GGT and GDH activities combined, as diagnostic tests for subclinical FE The latent class analysis estimated the true prevalence of subclinical FE in the study population as 47.5 (95% probability interval (PI) = 38.3–55.3)%. There was no evidence of any clinically relevant difference between GGT and GDH activities as predictors of subclinical FE; the difference between the areas under the receiver operating characteristic curves for the two measures was 0.005 (95% PI=–0.02 to –0.03). Using the two tests in parallel, with a threshold of 50 IU/L for GGT and 225 IU/L for GDH resulted in specificity and sensitivity of >95%, markedly increasing the accuracy of diagnosis of subclinical FE compared to using GGT or GDH alone at any threshold In this herd, combining the two tests resulted in a clinically relevant improvement in the accuracy of diagnosis of subclinical FE compared to using either test alone, which if used at the individual level will result in fewer cattle being assigned the wrong FE status. This will also apply at the herd level, with combined testing producing fewer false positive herd test results than using one enzyme alone. This is particularly important for monitoring the efficacy of FE control measures when the expectation should be that the proportion of cattle with FE is very low.
title: Arbeitsplatzbezogene Atemwegsbeschwerden – Auswertung einer Spezialsprechstunde
Creators: name: Kapp, Carolin
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: Berufskrankheit
subject: obstruktive Atemwegserkrankung
subject: Atemwegssprechstunde
subject: DDC Classification::5 Naturwissenschaften::50 Naturwissenschaften::500 Naturwissenschaften und Mathematik

description: Arbeitsplatzbezogene obstruktive Atemwegsbeschwerden gehören in Deutschland zu eher seltener angezeigten Berufskrankheiten (BKen, Nr. 4301 und Nr. 4302), obwohl sie im klinischen Alltag eine hohe differentialdiagnostische Relevanz hinsichtlich der Volkskrankheiten Asthma und der chronisch obstruktiven Lungenerkrankung (COPD) besitzen. Um jene BK-Anzeigen besser abzuklären und um eine adäquate therapeutische sowie präventive Versorgung zu ermöglichen, wurde 2012 in Kooperation mit der Berufsgenossenschaft für Gesundheitsdienst und Wohlfahrtspflege (BGW) am Institut und an der Poliklinik für Arbeits-, Sozial- und Umweltmedizin (IPASUM) eine spezielle arbeitsmedizinische Sprechstunde, die sog. Atemwegssprechstunde (AWS), eingeführt. Primäres Ziel der vorliegenden Arbeit ist die retrospektive Analyse jener Sprechstunde und ihres Patientenkollektivs aus den medizinischen Akten. Zusätzlich wurde im Rahmen eines größeren Forschungsprojekts eine aktuelle Verlaufsbefragung mittels Fragebogen durchgeführt; ausgewählte Aspekte hieraus sollen ebenfalls dargestellt werden.
description: Workplace-related obstructive respiratory symptoms are rarely reported as occupational diseases in Germany (BKs, No. 4301 and No. 4302), although they have a high differential diagnostic relevance in clinical practice with regard to the widespread diseases of asthma and chronic obstructive pulmonary disease (COPD). In order to better clarify these BK reports and to enable adequate therapeutic and preventive care, a special occupational medicine consultation, the so-called Atemwegssprechstunde (AWS), was introduced in 2012 at the Institute and outpatient clinic of occupational, social and environmental Medicine (IPASUM) in cooperation with the Employer's Liability Insurance Association for Health Services and Welfare Care (BGW). The primary aim of the present study is the retrospective analysis of this consultation and its patient base from the medical files. In addition, within the framework of a larger research project, an up-to-date follow-up survey was conducted by means of a questionnaire, from which selected aspects will also be presented.
title: Temperature influence on the propagation of liquid sprays in a crossflow
title: Einfluss der Temperatur auf die Ausbreitung von flüssigen Sprays in einer Querströmung
Creators: name: Weiß, Tatiana
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024
Subjects: subject: Spray
subject: Crossflow
subject: Injection
subject: Fuel
subject: Engine
subject: Combustion

description: Diese Arbeit befasst sich mit der Untersuchung des Temperatureinflusses auf die Ausbrei- tung von Sprays in einem ruhenden Medium und in einer Querströmung. Die zerstäubende Eindüsung von Flüssigkeiten ist in verschiedenen technischen Anlagen und Prozessen weit verbreitet. Zur Verbesserung und Optimierung des Betriebs technischer Geräte, bei denen die Ausbreitung des Sprays eine wichtige Rolle spielt, ist es notwendig, die Prinzipien und Muster der Spray-Ausbreitung bei verschiedenen Temperaturen sowohl in einem ruhenden Medium als auch in einer Querströmung zu verstehen. In dieser Arbeit werden die Ausbrei- tungsmuster von Ethanol- und Isooctan-Sprays bei verschiedenen Temperaturen vorgestellt, die experimentell ermittelt und mit Hilfe von CFD-Simulationen bestätigt wurden. Großes Augenmerk wird in dieser Arbeit auch auf die Analyse und Erklärung der erhaltenen Ergeb- nisse mit Hilfe der fundamentalen Gesetze der Physik gelegt. Die erhaltenen Muster können als Grundlage für künftige experimentelle Untersuchungen der sich unter üblichen Bedin- gungen ausbreitenden Sprays sowie für die Entwicklung mathematischer Modelle zur Be- schreibung und Optimierung verschiedener industrieller Prozesse mit der Ausbreitung von Flüssigkohlenwasserstoff-Sprays dienen.
description: This work is devoted to the investigation of the temperature influence on the spray propa- gation in a medium at rest and in a crossflow. Liquid sprays are widely used in various tech- nical installations and processes. To improve and optimize the operation of the technical devices where the spray propagation has a major role, it is necessary to understand the principles and patterns of the spray propagation at different temperatures both in a medi- um at rest and in a crossflow. This thesis presents the propagation patterns for ethanol and isooctane sprays of different temperatures which were experimentally obtained and con- firmed by means of CFD simulation. The thesis also pays great attention to analysis and explanation of the obtained results by means of fundamental laws of physics. The obtained patterns can serve as a basis for future experimental studies of the sprays propagating un- der common conditions, as well as for developing mathematical models for describing and optimising different industrial processes with the propagation of liquid hydrocarbon sprays.
Forecasting candidate states’ compliance with EU accession rules, 2017–2050
Creators: name: Böhmelt, Tobias
name: Freyburg, Tina
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The European Union (EU) is said to be tired of enlargement – but how likely is it that a candidate would be ready to join within 10, 15 or more years? This research forecasts how prospective members are likely able to perform in implementing EU law until 2050. Using compliance data of all states from the 2004, 2007 and 2013 accession rounds, as well as of five current/potential candidates, we construct an empirical model on candidates’ ability to comply with the acquis communautaire. We employ in-sample and out-of-sample techniques to ensure high model prediction accuracy and, ultimately, forecast the five candidates’ potential compliance levels in 2017–2050. Our research shows that only one candidate might sufficiently be able to comply with the accession criteria until 2023, while many are unlikely to be ready before the mid-2030s. Focusing on prediction and forecasting, our contribution is given by the research’s policy relevance and its methodological innovation.
Nozharov, Sht. (2014). Model of Effective Management of Bulgarian Public Administration Managing EU Funds, Economic Alternatives Journal, Issue 4, (64-77)
Creators: name: Nozharov, Sht.
Publisher: name: figshare
Year: 2017
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Abstract: The paper analyzes the possibilities of constructing a model for the effective management of the Bulgarian public administration responsible for managing the EU funds amid the global financial crisis by using McKinsey’s 7S model. The change of the management model of the public administration in charge of the absorption of EU funds in Bulgaria would increase the absorption rate of the funds while streamlining budgetary costs on the maintenance of the administration. The aim of the study is to identify the causes leading to the inadequate absorption of EU funds for Bulgaria and consider ways to address the problems. Such an analysis would be useful for countries applying for EU membership – Macedonia, Serbia, and Turkey to avoid repeating such mistakes. In addition, the analysis makes an attempt to identify some weaknesses of the structure in place in other EU member states such as Hungary and Slovenia.
Additional file 1 of Protective immunity induced by oral vaccination with a recombinant Lactococcus lactis vaccine against H5Nx in chickens
Creators: name: Ren, Yi
name: Lu, Xin
name: Yang, Zhonghe
name: Lei, Han
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Supplementary Figure 1. Full-length Western blots. M: Western blot marker; Lane 1: Cell culture supernatants of L. lactis/pNZ8149-HA1-M2; Lane 2: Cell lysates of L. lactis/pNZ8149-HA1-M2 (approximately 45 kDa); Lane 3: Cell lysates of L. lactis/pNZ8149; Lane 4: Cell culture supernatants of L. lactis/pNZ8149.
Nozharov, Sht. (2017). Efficiency of Public Administration Management in Cultural Heritage Protection. Economic Alternatives Journal, Issue 2, (307-316)
Creators: name: Nozharov, Sht.
Publisher: name: figshare
Year: 2017
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Abstract: The publication analyzes the possibilities of building a model for effective public administration management in the field of cultural heritage protection using McKinsey 7S model. Bulgaria is a country with rich cultural and archaeological heritage since Roman and Byzantine times. Significant number of cultural monuments are located on the territory of the country and are officially recognized as “world cultural heritage” by UNESCO. In this regard, the failures of Bulgarian cultural heritage protection will be a threat to the world cultural heritage protection. The main objective of the study is to propose measures for the development of management and control effectiveness of cultural heritage protection carried out by the public administration (the staff of the Bulgarian Ministry of Culture).
Optimising daytime deliveries when inducing labour using prostaglandin vaginal inserts
Creators: name: Miller, Hugh
name: Goetzl, Laura
name: Wing, Deborah A.
name: Powers, Barbara
name: Rugarn, Olof
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Objective: To determine induction start time(s) that would maximise daytime deliveries when using prostaglandin vaginal inserts. Methods: Women enrolled into the Phase III trial, EXPEDITE (clinical trial registration: NCT01127581), had labour induced with either a misoprostol or dinoprostone vaginal insert (MVI or DVI). A secondary analysis was conducted to determine the optimal start times for induction by identifying the 12-h period with the highest proportion of deliveries by parity and treatment. Results: Optimal start times for achieving daytime deliveries when using MVI appear to be 19:00 in nulliparae and 23:00 in multiparae. Applying these start times, the median time of onset of active labour would be approximately 08:30 for both parities and the median time of delivery would be the following day at approximately 16:30 for nulliparae and 12:00 (midday) for multiparae. Optimal start times when using DVI appear to be 07:00 for nulliparae and 23:00 for multiparae. Using these start times, the median time of onset of active labour would be the following day at approximately 04:00 and 11:50, and the median time of delivery would be approximately 13:40 and 16:10, respectively. Conclusions: When optimising daytime deliveries, different times to initiate induction of labour may be appropriate depending on parity and the type of retrievable prostaglandin vaginal insert used.
Nozharov, Shteryo. (2014). Model of Effective Management of Bulgarian Public Administration Managing EU Funds, Economic Alternatives Journal, Issue 4, (64-77)
Creators: name: Nozharov, Sht.
Publisher: name: figshare
Year: 2017
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Abstract: The paper analyzes the possibilities of constructing a model for the effective management of the Bulgarian public administration responsible for managing the EU funds amid the global financial crisis by using McKinsey’s 7S model. The change of the management model of the public administration in charge of the absorption of EU funds in Bulgaria would increase the absorption rate of the funds while streamlining budgetary costs on the maintenance of the administration. The aim of the study is to identify the causes leading to the inadequate absorption of EU funds for Bulgaria and consider ways to address the problems. Such an analysis would be useful for countries applying for EU membership – Macedonia, Serbia, and Turkey to avoid repeating such mistakes. In addition, the analysis makes an attempt to identify some weaknesses of the structure in place in other EU member states such as Hungary and Slovenia.
Nozharov, Shteryo. (2017). Efficiency of Public Administration Management in Cultural Heritage Protection. Economic Alternatives Journal, Issue 2, (307-316)
Creators: name: Nozharov, Sht.
Publisher: name: figshare
Year: 2017
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Abstract: The publication analyzes the possibilities of building a model for effective public administration management in the field of cultural heritage protection using McKinsey 7S model. Bulgaria is a country with rich cultural and archaeological heritage since Roman and Byzantine times. Significant number of cultural monuments are located on the territory of the country and are officially recognized as “world cultural heritage” by UNESCO. In this regard, the failures of Bulgarian cultural heritage protection will be a threat to the world cultural heritage protection. The main objective of the study is to propose measures for the development of management and control effectiveness of cultural heritage protection carried out by the public administration (the staff of the Bulgarian Ministry of Culture).
Additional file 5 of A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys
Creators: name: Jia, Huanhuan
name: Chen, Meili
name: Cai, Yanzhen
name: Luo, Xiaoling
name: Hou, Gang
name: Li, Yongfeng
name: Cai, Chunmei
name: Chen, Jun
name: Li, Qingnan
name: Miu, Kai-Kei
name: Fung, Sin-Hang
name: Wang, Zhangting
name: Huang, Ren
name: Shen, Huiyong
name: Lu, Li
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Virology

description: Additional file 5: Supplementary Table 5. Consistency between Homo sapiens and Macaca fascicularis for SNPs within previously confirmed risk loci.
Recall and patient perceptions of hip precautions 6 weeks after total hip arthroplasty
Creators: name: Lee, George R H
name: Berstock, James R
name: Whitehouse, Michael R
name: Blom, Ashley W
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background and purpose — There is a lack of evidence to support the role of hip precautions in preventing dislocation following total hip arthroplasty (THA). We report an exploratory study which assesses recall, adherence, and the impact of precautions on activities of daily living in the first 6 weeks postoperatively. Patients and methods — We designed a new questionnaire based on the education patients receive and refined by professionals within our multidisciplinary team. 129 patients underwent primary elective THA during the study period and received the questionnaire at 6 weeks postoperatively. Results — 97 (75%) patients responded before the 8th week postoperatively. Most of these (83 patients) could remember all the precautions. Of the 97 who responded only 22 claimed to adhere to all of the precautions. 48 admitted to putting their own underwear on without the use of aids or assistance, and 38 had started walking without an aid. Due to the precautions 67 avoided leaving the house at some point and 63 were unable to perform desired activities. 84 stated that their sleep was affected. There were no dislocations among the 97 patients who responded; however, there was 1 dislocation among the 32 non-responders. Interpretation — We found that most patients did not adhere to hip precaution advice. Precautions have a detrimental effect on patient activity and sleep. In view of the limited efficacy in reducing dislocation rate, we question the use of precautions in the primary arthroplasty setting.
TeaComposition experiment results in Mukhrino field station
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: Short-term standard litter decomposition across three different ecosystems in middle taiga zone of West Siberia. The method of standard litter (tea) decomposition was implemented to compare decomposition rate constants (k) between different peatland ecosystems and coniferous forests in the middle taiga zone of West Siberia (near Khanty-Mansiysk). The standard protocol of TeaComposition initiative was used to make the data usable for comparisons among different sites and zonobiomes worldwide. This article sums up the results of short-term decomposition (3 months) on the local scale. The values of decomposition rate constants differed significantly between three ecosystem types: it was higher in forest compared to bogs, and treed bogs had lower decomposition constant compared to Sphagnum lawns. We speculate that dry weather conditions could make large influence on decomposition dynamics in short-term scale and the experiment should be repeated in ongoing years thereby. In general, the decomposition rate constants were close to reported earlier for similar climatic conditions and habitats.
ML-Miner: A Machine Learning Tool Used for Identification of Novel Biosynthetic Gene Clusters
Creators: name: Wambo, Paul A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2022
Subjects: Machine Learning
BGC
Biosynthetic Gene Clusters

description: Identifying biosynthetic gene clusters from genomic data is challenging, with many in-silico tools suffering from a high rediscovery rate due to their dependence on rule-based algorithms. Next generation sequencing has provided an abundance of genomic information, and it has been hypothesized that there are many undiscovered biosynthetic gene clusters within this dataset. Here, we aim to develop a machine learning tool, ML-Miner, that infers patterns that describe a biosynthetic gene cluster in an unbiased manner and, as such, enables the identification of new biosynthetic gene clusters from genomic data. To solve this challenging problem, we define a simpler one to predict the class of a known BGC. Specifically, ML-Miner receives as input the concatenation of sequences that are known or believed to be part of a biosynthetic gene cluster. Its task is to identify which class it belongs, i.e. NPRS, PKS terpene and RiPPs. ML-Miner is a machine learning tool that uses Natural Language Processing, dimensionality reduction, and supervised learning to identify novel biosynthetic gene clusters. BioVec is a biological word embedding that we use to transform protein sequences from the highly curated MIBiG database of characterized biosynthetic gene clusters into their respective continuous distributed vector representations. Because the resulting protein vectors are of high dimensionality, a supervised Uniform Manifold and Approximation algorithm was employed to transform the high dimensional vectors into a robust lower-dimensional representation, as evaluated by Silhouette analysis, Hopkins’ statistic, and trustworthiness analysis. The density-Based Spatial Clustering of Applications and Noise algorithm showed that the clusters identified from the low dimensional datasets mapped to biosynthetic gene cluster types, defined with high accuracy in the MIBiG database. A random forest classifier was then trained and evaluated using the low dimensional vectors. It was shown to classify each biosynthetic gene cluster from the MIBiG database with excellent performance metrics. Finally, the model's ability to generalize was evaluated using biosynthetic gene clusters from the antiSMASH dataset, an uncurated database containing uncharacterized biosynthetic gene clusters. The performance metrics were high, with a balanced accuracy of ~85%. After a hyperparameter search, the balanced accuracy rose to ~90%. This suggests that ML-Miner is a robust machine learning pipeline that can be used to identify novel biosynthetic gene clusters. Future development of a confidence score for classification and a workflow for processing bacterial genomes into gene clusters will significantly improve the utility of this tool.
MOESM5 of Comprehensive genomic analysis of the DUF4228 gene family in land plants and expression profiling of ATDUF4228 under abiotic stresses
Creators: name: Yang, Qi
name: Niu, Xiaocui
name: Tian, Xiaona
name: Zhang, Xiujuan
name: Cong, Jingyu
name: Wang, Ruigang
name: Zhang, Guosheng
name: Li, Guojing
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Additional file 5: Figure S3. The motif compositions of DUF4228 proteins in plants. Motifs conserved across DUF4228 proteins were identified through MEME analysis.
A Kinect-based movement assessment system: marker position comparison to Vicon
Creators: name: Nichols, Julia K.
name: Sena, Mark P.
name: Hu, Jennifer L.
name: O’Reilly, Oliver M.
name: Feeley, Brian T.
name: Lotz, Jeffrey C.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Accurate movement analysis systems are prohibitive in cost and size to be accessible to the general population, while commercially available, affordable systems lack the accuracy needed for clinical relevance. To address these limitations, we developed a Depth Camera Movement Assessment System (DCMAS) featuring an affordable, widely available depth camera (e.g. Microsoft Kinect). After examining 3D position data for markers adhered to participants and a flat surface, captured with both DCMAS and the industry standard Vicon system, we demonstrated DCMAS obtained measurements comparable, within soft tissue artifact, to the Vicon system, paving the way for a breakthrough technology in preventative medicine.
Metal-selective coordination and enhanced fluorescence of a self-assembling ligand scaffold
Creators: name: Bogie, Paul M.
name: Lyon, Yana
name: Holloway, Lauren R.
name: Julian, Ryan R.
name: Hooley, Richard J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: A fluorescent hydroxyiminonicotinonitile (HINT) coordinating group can be incorporated into self-assembling ligand scaffolds, and shows metal-selective assembly and enhanced fluorescence. The assembly process is dependent on ligand coordination angle, and coordination only occurs for oxophilic first row transition metal ions, with affinity enhanced by the supramolecular assembly process. The ligands are weakly emissive, and show strong enhancement in fluorescence upon Zn2+ coordination, whereas Co2+ or Fe2+ cause complete quenching.
Air temperature measured near Lake Santo Parmense and Lake Scuro Parmense (1994-2010)
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: Dataset provides monthly average air temperature measured from 1994 to 2010 at the Lagdei weather station, which is the closest weather station to Lake Santo Parmense and Lake Scuro Parmense (about 1 km from Lake Santo Parmense and 5 km from Lake Scuro Parmense).
UHPLC-MS/MS phenolic profiling and in vitro antioxidant activities of Inula graveolens (L.) Desf
Creators: name: Silinsin, Muzaffer
name: Bursal, Ercan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Inula graveolens (L.) Desf. is an annual aromatic herb which has various uses on alternative medicine in many region of the world. In this study, antioxidant activities of ethanol and water extracts of the plant leaves were determined by in vitro DPPH method and phenolic composition of the plant sample was determined by LC-MS/MS analysis. The results showed that chlorogenic acid, quinic acid, hyperoside, protocatechuic acid and quercetin were the major phenolic compounds among the 27 standard compounds. The significant antioxidant capacity of the plant might be related with the high abundance of phenolic compounds.
Phytochemical analysis of Saponaria officinalis L. shoots and flowers essential oils
Creators: name: Petrović, Goran M.
name: Ilić, Marija D.
name: Stankov-Jovanović, Vesna P.
name: Stojanović, Gordana S.
name: Snežana Č. Jovanović
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: Phytochemical analysis by GC and GC/MS of the essential oil samples obtained from fresh shoots and flowers of Saponaria officinalis L. allowed the identification of 96 components in total, comprising 94.7% and 86.0% of the total oils compositions, respectively. Regarding the shoots essential oil, the major of 87 identified volatile compounds were phytol (14.1%), tricosane-6,8-dione (13.4%), patchouli alcohol (7.9%) and tricosane (7.2%), whereas patchouli alcohol (20.0%), heneicosane (11.5%) and tricosane (8.4%) were dominant among the 66 volatiles in the flower oil. Nonterpenoid compounds had the highest contribution in S. officinalis shoots essential oil (53.7%), while in the flower oil, constituents were almost evenly distributed between the oxygenated sesquiterpenoid (41.2%) and nonterpenoid compounds (39.5%).
title: I Can See It in Your Face.
title: Affective Valuation of Exercise in More or Less Physically Active Individuals
titleType: Subtitle
Creators: name: Brand, Ralf
name: Ulrich, Lukas
Publisher: name: Universität Potsdam
Year: 2020

description: The purpose of this study was to illustrate that people’s affective valuation of exercise can be identified in their faces. The study was conducted with a software for automatic facial expression analysis and it involved testing the hypothesis that positive or negative affective valuation occurs spontaneously when people are reminded of exercise. We created a task similar to an emotional Stroop task, in which participants responded to exercise-related and control stimuli with a positive or negative facial expression (smile or frown) depending on whether the photo was presented upright or tilted. We further asked participants how much time they would normally spend for physical exercise, because we assumed that the affective valuation of those who exercise more would be more positive. Based on the data of 86 participants, regression analysis revealed that those who reported less exercise and a more negative reflective evaluation of exercise initiated negative facial expressions on exercise-related stimuli significantly faster than those who reported exercising more often. No significant effect was observed for smile responses. We suspect that responding with a smile to exercise-related stimuli was the congruent response for the majority of our participants, so that for them no Stroop interference occurred in the exercise-related condition. This study suggests that immediate negative affective reactions to exercise-related stimuli result from a postconscious automatic process and can be detected in the study participants’ faces. It furthermore illustrates how methodological paradigms from social–cognition research (here: the emotional Stroop paradigm) can be adapted to collect and analyze biometric data for the investigation of exercisers’ and non-exercisers’ automatic valuations of exercise.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 597
Approximate tests for the equality of two cumulative incidence functions of a competing risk
Creators: name: Dobler, Dennis
name: Pauly, Markus
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: In the context of a competing risks set-up, we discuss different inference procedures for testing equality of two cumulative incidence functions, where the data may be subject to independent right-censoring or left-truncation. To this end, we compare two-sample Kolmogorov–Smirnov- and Cramér–von Mises-type test statistics. Since, in general, their corresponding asymptotic limit distributions depend on unknown quantities, we utilize wild bootstrap resampling as well as approximation techniques to construct adequate test decisions. Here, the latter procedures are motivated from tests for heteroscedastic factorial designs but have not yet been proposed in the survival context. A simulation study shows the performance of all considered tests under various settings and finally a real data example about bloodstream infection during neutropenia is used to illustrate their application.
title: Gesundheitsmonitoring mit Gesundheits-Apps und Wearables
title: Eine empirische Analyse der Nutzerinnen- und Nutzerprofile und ihrer Auswirkungen auf Selbstbestimmung und Solidaritätseinstellungen
titleType: Subtitle
Creators: name: Maier-Rigaud, Remi
name: Böning, Sarah-Lena
Publisher: name: Verbraucherzentrale Nordrhein-Westfalen e.V.: Kompetenzzentrum Verbraucherforschung NRW
Year: 2020

description: Gesundheits-Apps und Wearables erfreuen sich zunehmender Beliebtheit und ermöglichen, persönliche Gesundheitsdaten zu erfassen und auszuwerten oder allgemeine Gesundheitsinformationen zu erhalten. Im Rahmen des vorliegenden Forschungsprojektes wurden Nutzende und Nicht-Nutzende mittels einer Onlineumfrage sowie problemzentrierten qualitativen Interviews zu ihrem Nutzungsverhalten befragt. Ziel war die Exploration der Einstellungen und Erfahrungen in Bezug auf diese Technologien sowie die Selbstbestimmung der Nutzenden und ihre Solidaritätsbereitschaft innerhalb der Krankenversicherung.
description: Working Paper des KFV NRW
Rainfall in Herdade da Ribeira Abaixo R&M LTsER Montado
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: Dataset provides information about rainfall collected in Herdade da Ribeira Abaixo from 21th February 2014 to 4th January 2015. The rainfall within this dataset was measured in intervals of 30 minutes.
Evaluating an Online Intervention to Enhance Knowledge, Confidence and Skills in Undergraduate Students’ Responses to Bereaved Peers
Creators: name: Hill, Erin
Publisher: name: Digital Repository at the University of Maryland
Year: 2019
Subjects: online intervention

description: The purpose of this study was to conduct a randomized controlled trial to assess the efficacy of CARES, an online intervention developed to educate undergraduate students about how to communicate in person and over text with friends who experienced the death of someone close to them. College students (N=231) were randomly assigned to one of three conditions: (1) the CARES intervention, (2) a website containing information about grief and loss, or (3) a control condition. Participants completed pre- and post-test quantitative and qualitative measures to assess (1) knowledge of grief, appropriate responses to grieving peers, and resources available for grieving college students, (2) confidence in ability to communicate effectively with grieving peers, and (3) skills in communicating effectively with bereaved friends. The results indicated that students who participated in the CARES intervention had the greatest knowledge regarding grief and appropriate communication with grieving peers when compared to participants in the website and control conditions (when controlling for pre-test scores). In addition, students receiving the intervention were more confident in their ability to help a grieving peer and had the greatest skill in communicating with a grieving peer, when compared to participants in the website and control conditions. No differences were found in knowledge of common signs of grief or knowledge of resources. Thus, the CARES intervention has potential for educating undergraduates about effective communication with their grieving peers.
Indigenous Knowledges and Perspectives in University Journalism Education: Exploring experiences, challenges, and opportunities
Creators: name: Thomson, T.J.
name: McLaughlin, Julie
name: King-Smith, Leah
name: Tsimpikas, Matt
name: Bell, Aaron
Publisher: name: figshare
Year: 2022
Subjects: subject: 200201 Aboriginal and Torres Strait Islander Cultural Studies
subject: FOS: Other humanities
subject: 200101 Communication Studies
subject: FOS: Media and communications
subject: 200209 Multicultural, Intercultural and Cross-cultural Studies
subject: 190301 Journalism Studies
subject: Education
subject: 130301 Aboriginal and Torres Strait Islander Education
subject: FOS: Educational sciences
subject: 130103 Higher Education

description: News media coverage of Indigenous Australian peoples and perspectives is often absent or, when present, unfair or shallow in context or understanding. This raises the question of how much—and what kind of—exposure to Indigenous knowledges and perspectives journalists-in-training receive in their university studies. To find out, this study analyses 30 unit outlines and assessment details of journalism subjects at three Australian universities. It follows this analysis with interviews of 17 undergraduate journalism students at these universities to explore their perceptions of if and how their journalism programmes paid attention to Aboriginal and Torres Strait Islander topics and perspectives in the classroom setting. The results reveal that the journalism students in this sample, even those from the same university, had an uneven experience related to Indigenous knowledges and perspectives in their university journalism subjects. This testifies to the generic nature of unit outlines and learning objectives and to the broad discretionary power that individual tutors and lecturers have to shape the flow of information that is engaged with during the learning opportunities they oversee. Student recommendations for how Indigenous knowledges and perspectives could be more usefully integrated into journalism education were also gathered and reported.
Synthesis and characterization of organic dyes containing 4,5-diazafluorene as efficient sensitizers for dye-sensitized solar cells
Creators: name: Erden, Ibrahim
name: Cebeci, Caner
name: Kilicarslan, Fatma Aytan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Two dyes which are 4,5-diazafluoren-9-one-derived diimine ligands and their corresponding Ru(II) bipyridine complexes were synthesized. The structures of all compounds were determined by FTIR, UV–Vis, 1H-NMR, 1C-NMR, and MS spectroscopic data. The photovoltaic and electrochemical properties of these compounds were investigated and the applicability in DSSCs as photosensitizers was studied. The photovoltaic cell efficiencies (PCE) of the devices were 0.36–1.26% under simulated AM 1.5 solar irradiation of 100 mW/cm2, and the highest open-circuit voltage (Voc) reached 0.34 V. When comparing the photovoltaic performance of DSSC devices, efficiency increases L2 2). DSSC based on L1-Ru produced efficiency of 1.26%, whereas DSSC-based L1 exhibited the device performance with efficiency of 0.84% under illumination. These results show that the availability of a π-conjugated bridge and a richer electron donor for photovoltaic performance of the DSSC provides increased efficiency.
Ammonia in Lake Santo Parmense (1953- 1954)
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: Dataset provides ammonia concentrations measured in Lake Santo Parmense during the period 1953-1954. Water samples were collected by means of a Ruttner bottle only from the surface layer at the point of maximum depth of the lake. No information on the analytical method used is available.
Implementing enhanced training, management and monitoring of South Africa's ward-based primary healthcare outreach teams
Creators: name: Zech, Jennifer
Publisher: name: figshare
Year: 2022
Subjects: subject: Health Care
subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111717 Primary Health Care

description: The zip file includes transcripts and datasets from the evaluation: Implementing enhanced training, management and monitoring of South Africa's ward-based primary healthcare outreach teams.