cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-Fluid Simulations of Upper Chromospheric Magnetic Reconnection with Helium-Hydrogen mixture
Creators: name: Wargnier, Q. M.
name: Martinez-Sykora, J.
name: Hansteen, V. H.
name: De Pontieu, B.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Our understanding of magnetic reconnection (MR) under chromospheric conditions remains limited. Recent observations have demonstrated the important role of ion-neutral interactions in the dynamics of the chromosphere. Furthermore, the comparison between spectral profiles and synthetic observations of reconnection events suggest that current MHD approaches appear to be inconsistent with observations. First, collisions and multi-thermal aspects of the plasma play a role in these regions. Second, hydrogen and helium ionization effects are relevant to the energy balance of the chromosphere. This work investigates multi-fluid multi-species (MFMS) effects on MR in conditions representative of the upper chromosphere using the multi-fluid Ebysus code. We compare an MFMS approach based on a helium-hydrogen mixture with a two-fluid MHD model based on hydrogen only. The simulations of MRs are performed in a Lundquist number regime high enough to develop plasmoids and instabilities. We study the evolution of the MR and compare the two approaches including the structure of the current sheet and plasmoids, the decoupling of the particles, the evolution of the heating mechanisms, and the composition. The presence of helium species leads to more efficient heating mechanisms than the two-fluid case. This scenario, which is out of reach of the two-fluid or single-fluid models, can reach transition region temperatures starting from upper chromospheric thermodynamic conditions, representative of a quiet Sun scenario. The different dynamics between helium and hydrogen species could lead to chemical fractionation and, under certain conditions, enrichment of helium in the strongest outflows. This could be of significance for recent observations of helium enrichment in the solar wind in switchbacks and CMEs.
Synthesis, structure elucidation, Hirshfeld surface analysis, DFT, and molecular docking of new 6-bromo-imidazo[4,5-b]pyridine derivatives as potential tyrosyl-tRNA synthetase inhibitors
Creators: name: Jabri, Zainab
name: Thiruvalluvar, Aravazhi Amalan
name: Sghyar, Riham
name: Mague, Joel T.
name: Sabir, Safia
name: Rodi, Youssef Kandri
name: Anouar, El Hassane
name: Misbahi, Khalid
name: Sebbar, Nada Kheira
name: Essassi, El Mokhtar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Novel 6-bromo-imidazo[4,5-b]pyridine derivatives (2-4, 5a-13a, and 6b, 8b-13b) have been synthesized based on a developed systematic approach involving the condensation of 5-Bromo-2,3-diaminopyridine with a suitable aromatic aldehyde in the presence of molecular iodine in water, followed by alkylation reactions using different alkyl dibromide agents. The synthesized compounds were characterized by the NMR spectroscopy technique. The structures of 8a, 9a, 12a, and 11b were confirmed using monocrystalline X-ray crystallography. Theoretical calculations have been carried out using DFT and TD-DFT methods at the B3LYP/6-31G++(d,p) level of theory. Intermolecular contacts between units of 8a, 9a, 12a, and 11b were determined through the Hirshfeld surface analysis. The molecular docking study has been performed to determine the binding affinity of 8a, 9a, 12a, and 11b into the binding site of S. aureus tyrosyl-tRNA synthetase as a target enzyme, and the results revealed that 9a is the most potent compound among the selected compounds with a binding affinity of −8.74 Kcal/mol. Communicated by Ramaswamy H. Sarma
Interactions Between Moderate- and Long-Period Giant Planets: Scattering Experiments for Systems in Isolation and with Stellar Flybys
Creators: name: Boley, Aaron C.
name: Payne, Matthew J.
name: Ford, Eric B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The chance that a planetary system will interact with another member of its host star's nascent cluster would be greatly increased if gas giant planets form in situ on wide orbits. In this paper, we explore the outcomes of planet-planet scattering for a distribution of multiplanet systems that all have one of the planets on an initial orbit of 100 AU. The scattering experiments are run with and without stellar flybys. We convolve the outcomes with distributions for protoplanetary disk and stellar cluster sizes to generalize the results where possible. We find that the frequencies of large mutual inclinations and high eccentricities are sensitive to the number of planets in a system, but not strongly to stellar flybys. However, flybys do play a role in changing the low and moderate portions of the mutual inclination distributions, and erase dynamically cold initial conditions on average. Wide-orbit planets can be mixed throughout the planetary system, and in some cases, can potentially become hot Jupiters, which we demonstrate using scattering experiments that include a tidal damping model. If planets form on wide orbits in situ, then there will be discernible differences in the proper motion distributions of a sample of wide-orbit planets compared with a pure scattering formation mechanism. Stellar flybys can enhance the frequency of ejections in planetary systems, but auto-ionization is likely to remain the dominant source of free-floating planets.
description: Accepted for publication by ApJ
Gambling and Problem Gambling in North Dakota: A Replication Study, 1992 to 2000. Report to the North Dakota Office of the Governor
Creators: name: Volberg, Rachel A.
Publisher: name: Gemini Research, Ltd.
Year: 2001
Subjects: subject: Compulsive gambling -- North Dakota
subject: Gambling -- North Dakota
subject: Gambling Literature

description: This report presents the findings of a state-wide survey of gambling participation and gambling-related problems in North Dakota. This study is a replication of a baseline study that was carried out in North Dakota in 1992. The main purpose of this study was to examine changes in the prevalence of gambling and problem gambling in the adult population in North Dakota between 1992 and 2000. An additional purpose of this study was to identify the types of gambling causing the greatest difficulties for the citizens of North Dakota. The results of this study will be useful in documenting the impacts of legal gambling on the citizens of North Dakota and in refining the services available to individuals in North Dakota with gambling-related difficulties.
The high-energy environment in the super-earth system CoRoT-7
Creators: name: Poppenhaeger, K.
name: Czesla, S.
name: Schröter, S.
name: Lalitha, S.
name: Kashyap, V.
name: Schmitt, J. H. M. M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: High-energy irradiation of exoplanets has been identified to be a key influence on the stability of these planets' atmospheres. So far, irradiation-driven mass-loss has been observed only in two Hot Jupiters, and the observational data remain even more sparse in the super-earth regime. We present an investigation of the high-energy emission in the CoRoT-7 system, which hosts the first known transiting super-earth. To characterize the high-energy XUV radiation field into which the rocky planets CoRoT-7b and CoRoT-7c are immersed, we analyzed a 25 ks XMM-Newton observation of the host star. Our analysis yields the first clear (3.5 sigma) X-ray detection of CoRoT-7. We determine a coronal temperature of ca. 3 MK and an X-ray luminosity of 3*10^28 erg/s. The level of XUV irradiation on CoRoT-7b amounts to ca. 37000 erg/cm^2/s. Current theories for planetary evaporation can only provide an order-of-magnitude estimate for the planetary mass loss; assuming that CoRoT-7b has formed as a rocky planet, we estimate that CoRoT-7b evaporates at a rate of about 1.3*10^11 g/s and has lost ca. 4-10 earth masses in total.
description: 5 pages, accepted for publication by Astronomy & Astrophysics
Grain Growth In Azimuthal Dust Traps: Cycle 2 Observations Of Hd142527
Creators: name: Casassus, Simon
Publisher: name: Zenodo
Year: 2016

description: We discuss techniques to extract spectral trends from ALMA data, and estimate biases in the inferred physical conditions by comparison with simulations on radiative transfer predictions. We apply our diagnostics to recent ALMA datasets, including the radial variations in the HLTau rings, and new Cycle2 low-frequency  continuum observations of the azimuthal dust trap in HD142527.
The environmental burden on endocrine neoplasia: a review on the documented impact of endocrine disrupting chemicals
Creators: name: Mangion, Jessica
name: Gruppetta, Mark
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Endocrine-disrupting chemicals (EDCs) have gained more importance in the past decade, mostly due to their role in the pathogenesis of disease, especially in carcinogenesis. However, there is limited literature on the environmental burden on some of the less common endocrine neoplasia. This review focuses on both observational and experimental studies linking exposure to EDCs and endocrine neoplasia specifically pituitary, thyroid, adrenal and neuroendocrine tumors. Following PRISMA guidelines, a search of English peer-reviewed literature was performed using Medline and Google Scholar, giving preference to recent publications. Exposure to EDC occurs not only in the household but also at work, whether it is in the office, factory, or farm and during transport from one location to another. Many studies have evaluated the effect of single environmental agents; however, humans are rarely exposed to only one EDC. Different EDCs and different levels of exposure may interact together to provide either a synergistic and/or an antagonistic disruption on human health, and hence a complex mechanism to elucidate. The ultimate adverse effect is difficult to predict, as it is not only influenced by the degree of exposure, but also by genetics, lifestyle, comorbidities, and other stressors.
Thermochromic Metal Halide Perovskite Windows with Ideal Transition Temperatures
Creators: name: Rosales, Bryan A.
name: Kim, Janghyun
name: Wheeler, Vincent M.
name: Crowe, Laura E.
name: Prince, Kevin J.
name: Mirzokarimov, Mirzo
name: Daligault, Tom
name: Duell, Adam
name: Wolden, Colin A.
name: Schelhas, Laura T.
name: Wheeler, Lance M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Urban centers across the globe are responsible for a significant fraction of energy consumption and CO2 emission. As urban centers continue to grow, the popularity of glass as cladding material in urban buildings is an alarming trend. Dynamic windows reduce heating and cooling loads in buildings by passive heating in cold seasons and mitigating solar heat gain in hot seasons. In this work, we develop a mesoscopic building energy model that demonstrates reduced building energy consumption when thermochromic windows are employed. Savings are realized across eight disparate climate zones of the United States. We use the model to determine the ideal critical transition temperature of 20 to 27.5 °C for thermochromic windows based on metal halide perovskite materials. Ideal transition temperatures are realized experimentally in composite metal halide perovskite film composed of perovskite crystals and an adjacent reservoir phase. The transition temperature is controlled by co-intercalating methanol, instead of water, with methylammonium iodide and tailoring the hydrogen-bonding chemistry of the reservoir phase. Thermochromic windows based on metal halide perovskites represent a clear opportunity to mitigate the effects of energy-hungry buildings.
Structural analysis and ensemble docking revealed the binding modes of selected progesterone receptor modulators
Creators: name: Saritha, F.
name: Aiswarya, N.
name: Kumar, R. Aswath
name: Dileep, K.V.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Uterine fibroids (UF) are benign smooth muscle neoplasm of uterus that have a significant impact on a woman’s quality of life as they perturb hormonal homeostasis resulting in heavy menstrual bleeding, impaired fertility, pregnancy complications and loss. UF can be surgically removed through invasive procedures, but their recurrence rate is often high. Progesterone receptor (PR) has an imperative role in UF management. Mifepristone, ulipristal acetate (UPA) and asoprisnil (ASO) are some selective progesterone receptor modulators (SPRMs), acts on PR, but due to their side effects in long term use, they were withdrawn from the market. Hence, there is a dire need for novel, highly efficient with least side effects, therapeutics for the treatment of UF. To contribute toward the drug discovery for UF, we made an extensive structural comparison of reported PR crystal structures, also elucidated the binding modes of four existing SPRMs against human PR through ensemble docking approach. Our studies revealed the presence of 5 highly repeating water molecules that has an important role in ligand binding and structural stability. Our ensemble docking and MD simulation revealed that studied ligands have preferential selectivity toward the specific conformation of PR. It is anticipated that our study will be a useful resource to all the drug discovery scientists who are engaged in the identification of lead molecules against UF. Communicated by Ramaswamy H. Sarma
High-Resolution Observations In T Cha: The Atca And Alma View
Creators: name: De Gregorio-Monsalvo, Itziar
Publisher: name: Zenodo
Year: 2016

description: We present high-resolution observations with the ATCA interferometer at 7 mm and 1.7 cm, as well as with ALMA at 870 microns to characterize the physical parameters of the outer disk and gap in the transitional disk T Cha, as well as the

thermal dust emission at submillimeter and centimeter wavelengths.  We also compare our results with models predictions.
Base promoted coupling of α-ketoacids and 2-substituted aromatic amines: Green synthesis of diverse benzoxazoles, benzothiazoles, quinoxalinones and benzoxazinones and its practical application
Creators: name: Mathavan, Sivagami
name: Ramesh, Subburethinam
name: Yamajala, Rajesh B. R. D.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Synthesis of 2-aryl substituted benzoxazoles, benzothiazoles, and quinoxalinones via decarboxylative coupling of α-keto acids with 2-aminophenol, 2-aminothiophenol, and OPD (o-phenylenediamine), using K2CO3 as a base in water at room temperature, and as well as solvent-free grinding and the synthesis of benzoxazinones from the reaction of α-keto acids with 2-aminophenol at 60 °C have been reported. Both the protocols afforded a wide range of desired products with excellent functional group tolerance in yields of 87–99%. The major advantages of these approaches are catalyst-free protocol, short reaction times, straightforward workup, and chromatography-free processing of the products. Additionally, to test the translational demand of this methodology, the synthesis of 2-(3,5-dichlorophenyl)-6-methylbenzo[d]oxazole was carried out which is a key structure of tafamidis, a commercially available drug.
Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids
Creators: name: Hasan, Aso Hameed
name: Shakya, Sonam
name: Hussain, Faiq H.S.
name: Murugesan, Sankaranarayanan
name: Chander, Subhash
name: Pratama, Mohammad Rizki Fadhil
name: Jamil, Shajarahtunnur
name: Das, Basundhara
name: Biswas, Subhrajit
name: Jamalis, Joazaizulfazli
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified

description: The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors (AChEIs) are the most prescribed class of medications for the treatment of Alzheimer’s disease (AD) and dementia. The limitations of available therapy, like side effects, drug tolerance, and inefficacy in halting disease progression, drive the need for better, more efficacious, and safer drugs. In this study, a series of fourteen novel chalcone-coumarin derivatives (8a-n) were designed, synthesized and characterized by spectral techniques like FT-IR, NMR, and HR-MS. Subsequently, the synthesized compounds were tested for their ability to inhibit acetylcholinesterase (AChE) activity by Ellman’s method. All tested compounds showed AChE inhibition with IC50 value ranging from 0.201 ± 0.008 to 1.047 ± 0.043 μM. Hybrid 8d having chloro substitution on ring-B of the chalcone scaffold showed relatively better potency, with IC50 value of 0.201 ± 0.008 μM compared to other members of the series. The reference drug, galantamine, exhibited an IC50 at 1.142 ± 0.027 μM. Computational studies revealed that designed compounds bind to the peripheral anionic site (PAS), the catalytic active site (CAS), and the mid-gorge site of AChE. Putative binding modes, ligand-enzyme interactions, and stability of the best active compound are studied using molecular docking, followed by molecular dynamics (MD) simulations. The cytotoxicity of the synthesised derivatives was determined using the MTT test at three concentrations (100 g/mL, 500 g/mL, and 1 mg/mL). None of the chemicals had a significant effect on the body at the highest dose of 1 mg/mL. Communicated by Ramaswamy H. Sarma
Comparison of complication and conversion rates between robotic-assisted and laparoscopic rectal resection for rectal cancer: which patients and providers could benefit most from robotic-assisted surgery?
Creators: name: Ackerman, Stacey J.
name: Daniel, Shoshana
name: Baik, Rebecca
name: Emelline Liu
name: Mehendale, Shilpa
name: Tackett, Scott
name: Minia Hellan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer

description: Aims: To compare (1) complication and (2) conversion rates to open surgery (OS) from laparoscopic surgery (LS) and robotic-assisted surgery (RA) for rectal cancer patients who underwent rectal resection. (3) To identify patient, physician, and hospital predictors of conversion. Materials and methods: A US-based database study was conducted utilizing the 2012–2014 Premier Healthcare Data, including rectal cancer patients ≥18 with rectal resection. ICD-9-CM diagnosis and procedural codes were utilized to identify surgical approaches, conversions to OS, and surgical complications. Propensity score matching on patient, surgeon, and hospital level characteristics was used to create comparable groups of RA\LS patients (n = 533 per group). Predictors of conversion from LS and RA to OS were identified with stepwise logistic regression in the unmatched sample. Results: Post-match results suggested comparable perioperative complication rates (RA 29% vs LS 29%; p = .7784); whereas conversion rates to OS were 12% for RA vs 29% for LS (p p Limitations: Retrospective observational study limitations apply. Analysis of the hospital administrative database was subject to the data captured in the database and the accuracy of coding. Propensity score matching limitations apply. RA and LS groups were balanced with respect to measured patient, surgeon, and hospital characteristics. Conclusions: Compared to LS, RA offers a higher probability of completing a successful minimally invasive surgery for rectal cancer patients undergoing rectal resection without exacerbating complications. Male, obese, or moderately-to-severely ill patients had higher conversion rates. While colorectal surgeons had lower conversion rates from RA than LS, the reduction was magnified for general surgeons and smaller bed-size hospitals.
Data Processing Techniques for Ion and Electron Energy Distribution Functions
Creators: name: Caldarelli, Antonella
name: Filleul, Félicien
name: Boswell, Rod
name: Charles, Christine
name: Rattenbury, Nicholas
name: Cater, John
Publisher: name: arXiv
Year: 2022
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Retarding field energy analyzers and Langmuir probes are routinely used to obtain ion and electron energy distribution functions (IEDF, EEDF). These typically require knowledge of the first and second derivatives of the I-V characteristics, both of which can be obtained in various ways. This poses challenges inherent to differentiating noisy signals, a frequent problem with electric-probe plasma diagnostics. A brief review of commonly used analog and numerical filtering and differentiation techniques is presented, together with their application on experimental data collected in a radio-frequency plasma. The application of each method is detailed with regards to the obtained IEDF and EEDF, the deduced plasma parameters, dynamic range, energy resolution and signal distortion.
description: A.C. and F.F. are co-first authors. The following article has been submitted to Physics of Plasmas. After it is published, it will be found at https://aip.scitation.org/journal/php
Cost-effectiveness of TYRX absorbable antibacterial envelope for prevention of cardiovascular implantable electronic device infection
Creators: name: Kay, Gemma
name: Eby, Elizabeth L.
name: Brown, Benedict
name: Lyon, Julie
name: Eggington, Simon
name: Gayathri Kumar
name: Fenwick, Elisabeth
name: M. Rizwan Sohail
name: Wright, David Jay
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Aims: Infection is a major complication of cardiovascular implantable electronic device (CIED) therapy that usually requires device extraction and is associated with increased morbidity and mortality. The TYRX Antibacterial Envelope is a polypropylene mesh that stabilizes the CIED and elutes minocycline and rifampin to reduce the risk of post-operative infection. Methods: A decision tree was developed to assess the cost-effectiveness of TYRX vs standard of care (SOC) following implantation of four CIED device types. The model was parameterized for a UK National Health Service perspective. Probabilities were derived from the literature. Resource use included drug acquisition and administration, hospitalization, adverse events, device extraction, and replacement. Incremental cost-effectiveness ratios (ICERs) were calculated from costs and quality-adjusted life-years (QALYs). Results: Over a 12-month time horizon, TYRX was less costly and more effective than SOC when utilized in patients with an ICD or CRT-D. TYRX was associated with ICERs of £46,548 and £21,768 per QALY gained in patients with an IPG or CRT-P, respectively. TYRX was cost-effective at a £30,000 threshold at baseline probabilities of infection exceeding 1.65% (CRT-D), 1.95% (CRT-P), 1.87% (IPG), and 1.38% (ICD). Limitations and conclusions: Device-specific infection rates for high-risk patients were not available in the literature and not used in this analysis, potentially under-estimating the impact of TYRX in certain devices. Nevertheless, TYRX is associated with a reduction in post-operative infection risk relative to SOC, resulting in reduced healthcare resource utilization at an initial cost. The ICERs are below the accepted willingness-to-pay thresholds used by UK decision-makers. TYRX, therefore, represents a cost-effective prevention option for CIED patients at high-risk of post-operative infection.
White abalone at San Clemente Island : population estimates and management recommendations
Creators: name: Stierhoff, Kevin L.
name: Mau, Scott A.
name: Murfin, David W.
name: Neumann, Melissa
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Southwest Fisheries Science Center
Year: 2014
Subjects: subject: White abalone--Counting--California--San Clemente Island

description: White abalone (Haliotis sorenseni), a marine mollusk indigenous to southern California, was listed as endangered in 2001. In 2004, underwater surveys using a remotely operated vehicle (ROV) identified several remnant populations of white abalone, including one along the west and south shores of San Clemente Island (SCI). In 2012, another survey of white abalone habitats was conducted at SCI to examine potential changes in that population. White abalone are sparse at SCI; only five white abalone (mean shell length of 17.2 cm (standard deviation (SD) = 2.2 cm and 17.7 cm (SD = 1.8 cm) in 2004 and 2012, respectively) were observed in each of the two surveys. Average densities were 0-1.24 abalone per hectare (ha-1) in 2004 and 0.27-1.44 abalone ha-1 in 2012, which resulted in a slight increase in the population from 353 (standard error (SE) = 62) to 565 (SE = 136) white abalone during that time. However, the low density and patchy distribution of white abalone at SCI resulted in high coefficients of variation (CVs) for population estimates in all years and depths (CV = 0.70-0.96). In order to slow down or halt the progression towards local extinction at SCI, NMFS recommends the following steps be taken: 1) the U.S. Navy (Navy) should continue to support research and monitoring efforts that focus on learning more about the movements, growth and spawning behavior of its small but persistent population; 2) the Navy should continue its outreach and education mission in order to discourage illegal take of all abalone species at SCI; and 3) the Navy should consider the locations of the observed animals when planning operations that may impact white abalone or its habitat at SCI. These recommendations are provided at the request of the Navy as stipulated in the funding agreement.
Gambling and problem gambling among adolescents in Washington State : a replication study, 1993 to 1999, report to the Washington State Lottery
Creators: name: Volberg, Rachel A.
name: Moore, W. Lamar
Publisher: name: Gemini Research, Ltd.
Year: 1999
Subjects: subject: Gambling -- Washington (State)
subject: Compulsive gambling -- Washington (State)
subject: Teenagers -- Washington (State) -- Economic conditions
subject: Teenagers -- Washington (State) -- Social conditions
subject: Gambling Literature

description: This report presents the results of a replication survey of adolescent gambling and problem gambling in Washington State. The main purpose of this study was to examine changes in gambling participation and the prevalence of gambling-related problems among adolescents in Washington State between 1993 and 1999. Another purpose of this study was to identify the types of gambling causing the greatest difficulties for the youth of Washington State. A sample of Washington State residents aged 13 to 17 (N=1,000) were interviewed in January and February, 1999, about the types of gambling they have tried, the amounts of money they spend on gambling and about gambling-related difficulties. The results of this study are intended to assist in refining the services available to youth with gambling problems as well as their families in Washington State.
Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,4-oxadiazole incorporated indazole-isoxazole derivatives
Creators: name: Lingam, Jesse
name: Sahoo, Bijaya Ketan
name: Mallavarapu, Bala Divya
name: Sreenivasulu, Reddymasu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Cell Biology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer

description: A new series of 1,2,4-oxadiazole incorporated indazole-isoxazole (12a–j) derivatives were designed, synthesized and confirmed their structures by 1HNMR, 13CNMR and mass spectral analysis. Further, all compounds were evaluated for their anticancer activity against a panel of human cell lines like breast cancer (MCF-7), lung cancer (A549), prostate cancer (DU-145) and breast cancer (MDA MB-231) by using MTT assay. The etoposide used as a reference drug and the results were expressed with IC50 (µM). Most of the compounds were showed good to moderate activity with respective cell lines. Among them, compounds 12b, 12e, 12 g, 12h and 12i have exhibited more potent activity as compared with the reference drug etoposide. In which one of the compound 12i has showed most significant activity. Molecular docking studies were carried out using PyRx tool and visualized through Chimera and Pymol visualization tools, revealed that the interactions between the active site of the tubulin with the selected compound 12i exhibited good interactions with the active site amino acids. These findings suggested that the 12i compound acts as a potential binder to the tubulin complex. These results revealed that the selected synthesized compounds were used in anticancer therapies.
Physical properties of dense molecular gas in centres of Seyfert galaxies
Creators: name: Sani, E.
name: Davies, R. I.
name: Sternberg, A.
name: Gracia-Carpio, J.
name: Hicks, E. K. S.
name: Krips, M.
name: Tacconi, L. J.
name: Genzel, R.
name: Vollmer, B.
name: Schinnerer, E.
name: Garcia-Burillo, S.
name: Usero, A.
name: de Xivry, G. Orban
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present new ~1" resolution data of the dense molecular gas in the central 50-100 pc of four nearby Seyfert galaxies. PdBI observations of HCN and, in 2 of the 4 sources, simultaneously HCO+ allow us to carefully constrain the dynamical state of the dense gas surrounding the AGN. Analysis of the kinematics shows large line widths of 100-200 km/s FWHM that can only partially arise from beam smearing of the velocity gradient. The observed morphological and kinematic parameters (dimensions, major axis position angle, red and blue channel separation, and integrated line width) are well reproduced by a thick disk, where the emitting dense gas has a large intrinsic dispersion (20-40 km/s), implying that it exists at significant scale heights (25-30% of the disk radius). To put the observed kinematics in the context of the starburst and AGN evolution, we estimate the Toomre Q parameter. We find this is always greater than the critical value, i.e. Q is above the limit such that the gas is stable against rapid star formation. This is supported by the lack of direct evidence, in these 4 Seyfert galaxies, for on-going star formation close around the AGN. Instead, any current star formation tends to be located in a circumnuclear ring. We conclude that the physical conditions are indeed not suited to star formation within the central ~100 pc.
description: 15 pages, 13 figures, 7 tables. Accepted for pubblication in MNRAS
Gambling Behaviors and Problem Gambling Among Adolescents in New York State: Initial Findings from the 2006 OASAS School Survey
Creators: name: Rainone, Gregory
name: Gallati, Robert J.
Publisher: name: New York State Office of Alcoholism and Substance Abuse Servic
Year: 2007
Subjects: subject: Teenage gamblers -- New York State
subject: Gambling -- New York State
subject: Compulsive gambling -- New York State
subject: Gambling Literature

description: The most recent OASAS School Survey was conducted in the spring of 2006. The focus of the survey was on gambling behavior and problems. Questionnaire items addressed the frequency of engaging in 14 different gambling activities during the past year, the frequency of gambling in the past 30 days, diagnostic criteria and risk and protective factors affecting gambling behavior. This brief report describes initial findings regarding gambling behavior and problems.
Rymosia pseudocretensis Burghele-Balacesco 1967
Creators: name: El Mouden, Mohamed Amin
name: Chandler, Peter J.
name: Saidoun, Imane
name: Driauach, Ouafaa
name: Belqat, Boutaïna
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Mycetophilidae
Rymosia
Rymosia pseudocretensis

description: Rymosia pseudocretensis Burghele-Balacesco, 1967
Material examined.
Morocco – Middle Atlas Region • 2 ♂♂; Gouffre Izora; 19/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24124.
North African distribution.
Algeria (Burghele-Balacesco 1967); Morocco (Chandler 1994; Chandler et al. 2006; Banamar et al. 2020).
description: Published as part of El Mouden, Mohamed Amin, Chandler, Peter J., Saidoun, Imane, Driauach, Ouafaa & Belqat, Boutaïna, 2025, A new species of Docosia Winnertz, 1864 and new records of fungus gnats (Diptera, Bolitophilidae, Keroplatidae and Mycetophilidae) from North Africa, pp. 349-379 in ZooKeys 1233 on pages 349-379, DOI: 10.3897/zookeys.1233.130502
Determination of sub-resolution structure of jet by solar magnetoseismology
Creators: name: Morton, R. J.
name: Verth, G.
name: McLaughlin, J. A.
name: Erdélyi, R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A thin dark thread is observed in a UV/EUV solar jet in the 171A, 193A and 211A and partially in 304A. The dark thread appears to originate in the chromosphere but its temperature does not appear to lie within the passbands of the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO). We therefore implement solar magnetoseismology to estimate the plasma parameters of the dark thread. A propagating fast kink (transverse) wave is observed to travel along the dark thread. The wave is tracked over a range of ~7000km by placing multiple slits along the axis of the dark thread. The phase speed and amplitude of the wave are estimated and magnetoseismological theory is employed to determine the plasma parameters. We are able to estimate the plasma temperature, density gradient, magnetic field gradient and sub-resolution expansion of the dark thread. The dark thread is found to be cool, T~3x10^4$ with both strong density and magnetic field gradients. The expansion of the flux tube along its length is ~300-400km.
description: Accepted ApJ, Publication expected Novemember 2011
Boundary conditions and the dynamics of a dissipative granular gas: slightly dense case
Creators: name: Evesque, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The effect of different possible kinds of motion of the exciting walls (cyclic, random, ...) is investigated on the dynamics of a granular dissipative gas. It is shown that the real distribution of speed of the wall which interact with the balls depend strongly on the real ball speed, due to a screening effect, so that the transfer of excitation from the walls to the cloud of particles may drastically depend on the ball speed itself. This makes the excitation quite non linear, with a change of efficiency law. This may explain the observation of a biphasic cloud when the mean free path of balls is slightly smaller than the cell size L, or may predict that the particles in the cloud is merely at rest as soon as the mean free path is smaller than L/10. It is obvious that the vibrating cell cannot be considered as a thermostat.
Design, synthesis, and antimicrobial evaluation of new antipyrine derivatives bearing thiazolopyridazine and pyrazolothiazole scaffolds
Creators: name: Alamshany, Zahra M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: In the current research, a new set of antipyrine–thiazole hybrids were designed and synthesized and screened for their antimicrobial activities against Gram-positive and Gram-negative bacteria and fungal strains using ciprofloxacin and nystatin as reference drugs. The antipyrine derivatives 3a, 5a, 7c, and 11a revealed promising and broad antibacterial activity especially against S. aureus, followed by in vitro enzyme inhibitory assay against S. aureus DNA gyrase to predict the mechanism of action. The thiazole 3a and pyrazolo[4,3-d]thiazole 7c afforded superior inhibitory activity against S. aureus DNA gyrase (IC50 = 0.292 ± 0.15 and 0.255 ± 0.10 µM, respectively) in comparison with ciprofloxacin (IC50 = 0.331 ± 0.20 µM). Finally, the in silico molecular docking and ADME studies were established to give better rationalization and optimization of efficient new antimicrobial leads.
Real-world comparison of all-cause hospitalizations, hospitalizations due to stroke and major bleeding, and costs for non-valvular atrial fibrillation patients prescribed oral anticoagulants in a US health plan
Creators: name: Alpesh Amin
name: Keshishian, Allison
name: Vo, Lien
name: Qisu Zhang
name: Oluwaseyi Dina
name: Patel, Chad
name: Odell, Kevin
name: Trocio, Jeffrey
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Aims: To compare the risk of all-cause hospitalization and hospitalizations due to stroke/systemic embolism (SE) and major bleeding, as well as associated healthcare costs for non-valvular atrial fibrillation (NVAF) patients initiating apixaban, dabigatran, rivaroxaban, or warfarin. Materials and methods: NVAF patients initiating apixaban, dabigatran, rivaroxaban, or warfarin were selected from the OptumInsight Research Database from January 1, 2013–September 30, 2015. Propensity score matching (PSM) was performed between apixaban and each oral anticoagulant. Cox models were used to estimate the risk of stroke/SE and major bleeding. Generalized linear and 2-part models were used to compare healthcare costs. Results: Of the 47,634 eligible patients, 8,328 warfarin-apixaban pairs, 3,557 dabigatran-apixaban pairs, and 8,440 rivaroxaban-apixaban pairs were matched. Compared to apixaban, warfarin patients were associated with a significantly higher risk of all-cause (hazard ratio [HR] = 1.30; 95% confidence interval [CI] = 1.21–1.40) as well as stroke/SE-related (HR = 1.60; 95% CI = 1.23–2.07) and major bleeding-related (HR = 1.95; 95% CI = 1.60–2.39) hospitalization; rivaroxaban patients were associated with a higher risk of all-cause (HR = 1.15; 95% CI = 1.07–1.24) and major bleeding-related hospitalization (HR = 1.71; 95% CI = 1.39–2.10); and dabigatran patients were associated with a higher risk of major bleeding hospitalization (HR = 1.46, 95% CI = 1.02–2.10). Warfarin patients had significantly higher major bleeding-related and total all-cause healthcare costs compared to apixaban patients. Rivaroxaban patients had significantly higher major bleeding-related costs compared to apixaban patients. No significant results were found for the remaining comparisons. Limitations: No causal relationships can be concluded, and unobserved confounders may exist in this retrospective database analysis. Conclusions: This study demonstrated a significantly higher risk of hospitalization (all-cause, stroke/SE, and major bleeding) associated with warfarin, a significantly higher risk of major bleeding hospitalization associated with dabigatran or rivaroxaban, and a significantly higher risk of all-cause hospitalization associated with rivaroxaban compared to apixaban. Lower major bleeding-related costs were observed for apixaban patients compared to warfarin and rivaroxaban patients.
Gambling and problem gambling among adolescents in Washington State : report to the Washington State Lottery
Creators: name: Volberg, Rachel A.
name: Washington State Lottery
Publisher: name: Gemini Research
Year: 1993
Subjects: subject: Gambling -- Washington (State)
subject: Compulsive gambling -- Washington (State)
subject: Teenagers -- Washington (State) -- Economic conditions
subject: Teenagers -- Washington (State) -- Social conditions
subject: Gambling Literature

description: This report presents the findings of a state-wide survey of gambling involvement and problem gambling among adolescents in Washington State. This is the first adolescent study initiated and funded by a state lottery and the first study that allows comparisons of adolescent and adult gambling involvement in the same jurisdiction. A random sample of 1,054 Washington State adolescents aged 13 to 17 was interviewed in January and February of 1993 about the types of gambling in which they had ever participated, the amounts of money they spend on gambling, the problems related to their gambling and about other risky behaviors including alcohol and drug use.
Photoacoustic characterization of TiO2 thin-films deposited on Silicon substrate using neural networks
Creators: name: Djordjevic, Katarina Lj
name: Markushev, Dragana K
name: Popovic, Marica N
name: Nesic, Mioljub V
name: Galovic, Slobodanka P
name: Lukic, Dragan V
name: Markushev, Dragan D
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this paper, the possibility of determining the thermal, elastic and geometric characteristics of a thin TiO2 film deposited on a silicon substrate, thickness 30 mikrons, in the frequency range of 20 to 20 kHz with neural networks was analyzed. For this purpose, the substrate parameters remained the known and constant in the two-layer model and nano layer thin-film parameters were changed: thickness, expansion and thermal diffusivity. Prediction of these three parameters was analyzed separately with three neural networks and all of these together by fourth neural network. It was shown that neural network, which analyzed all three parameters at the same time, achieved the highest accuracy, so the use of networks that provide predictions for only one parameter is less reliable.
description: 21 pages, 5 figures
Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies
Creators: name: Taghour, Mohammed S.
name: Elkady, Hazem
name: Eldehna, Wagdy M.
name: El-Deeb, Nehal
name: Kenawy, Ahmed M.
name: El-Wahab, Abeer E Abd
name: Elkaeed, Eslam B.
name: Alsfouk, Bshra A.
name: Metwaly, Ahmed M.
name: Eissa, Ibrahim H.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2 inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit VEGFR-2 was found to be strong with IC50 values in the range of 76.64–175.50 nM. To investigate the cytotoxicity and safety, all compounds were tested against a panel of four cancer cell lines (A549, Caco2, HepG2 and MDA) as well as two normal cell lines (Vero and WI-38). Interestingly, compound 12 exhibited noticeable cytotoxicity against A549, Caco2 and MDA with IC50 values of 5.40, 0.58 and 0.94 µM, respectively. These results were better and comparable to that of doxorubicin (0.70, 0.82 and 0.90 µM, respectively) with more than three folds higher selectivity index against the Caco2 cell lines. Compound 9 prevented the healing of the cancer cells at a low concentration. Also, the compound’s potential to induce programmed cell death in Caco-2 was proved through the significant down regulating of the expression of Bcl2, Bcl-xl and Survivin in addition to the slight upregulation of the TGF-β gene. The cell cycle analysis indicated that compound 9 arrested the Caco-2 cells in the G2/M phase. Interestingly, the molecular docking studies against VEGFR-2 revealed the correct binding of the targeted compounds similar to sorafenib. Furthermore, MD experiments validated the binding of compound 12 with VEGFR-2 over 100 ns, as well as MM-PBSA analysis that confirmed the precise binding with optimum energy. Finally, ADMET analysis showed the general drug-likeness and confirmed the safety of the tested compounds. Communicated by Ramaswamy H. Sarma
Comparing Accretion Disks and Dark Matter Spikes in Intermediate Mass Ratio Inspirals
Creators: name: Becker, Niklas
name: Sagunski, Laura
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Intermediate Mass Ratio Inspirals (IMRIs) will be observable with space-based gravitational wave detectors such as the Laser Interferometer Space Antenna (LISA). To this end, the environmental effects in such systems have to be modeled and understood. These effects can include (baryonic) accretion disks and dark matter (DM) overdensities, so called spikes. For the first time, we model an IMRI system with both an accretion disk and a DM spike present and compare their effects on the inspiral and the emitted gravitational wave signal. We study the eccentricity evolution, employ the braking index and derive the dephasing index, which turn out to be complementary observational signatures. They allow us to disentangle the accretion disk and DM spike effects in the IMRI system.
description: 16 pages, 8 figures. Submitted to PRD. Code available online at http://github.com/DMGW-Goethe/imripy