Metadata record for the manuscript: Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation
Creators: name: Yoon, Sang-Ho
name: Seo-Won Choi
name: Nam, Suk Woo
name: Lee, Kyoung Bun
name: Nam, Jin-Wu
Publisher: name: figshare
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Cancer
subject: Biomarkers

description: <b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related manuscript: “Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation”. The related study explored how preestablished immune landscapes in premalignant and early hepatocellular carcinoma (HCC) stages impact the clinical outcomes of HCC patients. Type of data: RNA sequencing, immunohistochemistry Subject of data: <i>Homo sapiens</i> Sample size: 62 malignant tumor samples from a Korean HCC cohort in which 38 patients underwent total hepatectomy, as well as for 15 nontumor samples and 47 premalignant lesions. Population characteristics: Korean HCC patients who had surgical resection at Seoul National University Hospital between 2004 and 2009 were sequenced in pared or un-paired manner. Total of 62 tumor samples were collected. Nontumor samples were collected from patients with metastatic cancer, cholangiocarcinoma, or polycystic liver disease after histological confirmation. One nontumor sample was collected from a metastatic cancer patient who underwent partial hepatectomy, and other 14 nontumor samples were collected from patients with cholangiocarcinoma, or polycystic liver disease after histological confirmation. Additional 47 premalignant lesions were prepared in which 24 samples were paired with tumor samples. Recruitment: Patients who had surgical resection at Seoul National University Hospital between 2004 and 2009 were subjected for sequencing after receiving written informed consent from the patients according to the Declaration of Helsinki. <b>Data access</b> The normalised gene expression and raw data supporting the conclusions of the article are available in the NCBI <i>Gene Expression Omnibus</i> (GEO) database under accession number https://identifiers.org/geo:GSE148355. Raw Immunohistochemistry data underlying Figure 3 and Supplementary Figure 6 in the manuscript are available in <i>figshare </i>at https://doi.org/10.6084/m9.figshare.13729081.v1. A spreadsheet containing the 430 pooled genes related to the EMT process is available in <i>figshare </i>at https://doi.org/10.6084/m9.figshare.13729108.v1. Clinical metadata for the extended Korean HCC cohorts, liver transplantation (LT) and surgical resection (non-LT) data are available in <i>figshare </i>at https://doi.org/10.6084/m9.figshare.13883321.v1. <b> </b> <b>Corresponding author(s) for this study</b> Jin-Wu Nam, Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea, jwnam@hanyang.ac.kr. Kyoung Bun Lee, Department of Pathology, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea. kblee@snuh.org. <br> <b>Study approval </b> The Institutional Review Board of Seoul National University Hospital (H-1501-042-639).