cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Broadband enabled healthcare: The role and contribution of Health and Biomedical Informatics
Creators: name: Martin Sanchez, Fernando
name: Gray, Kathleen
Publisher: name: Swinburne
Year: 2024

description: One way to think about broadband enabled healthcare is as a system where the use of health information is facilitated by ultra-high-speed, high-capacity, ubiquitous, ‘always-on’
connectivity. Broadband marks a radical departure from the way information can be used in healthcare currently, and is anticipated to transform healthcare outcomes in terms of access
and equity, safety and quality, sustainability and innovation. In Australia a national broadband network is recognised as a key to achieving a suite of national health system reforms collectively described as the national ehealth system. The information aspects of broadband enabled healthcare are clearly within the scope of health and biomedical informatics. The
fundamental place of health and biomedical informatics in broadband enabled health has also been recognised in a major broadband research centre (IBES), which has harnessed the
discipline of health and biomedical informatics to coordinate the health and wellbeing piece of its research program. This paper argues that the discipline of Health and Biomedical Informatics has a substantial role to play in ensuring that strategy, technology, accountability and usability are properly integrated in the design, implementation and evaluation of
broadband enabled healthcare.
The role of bone morphogenetic protein 7 in cortical neurogenesis
Creators: name: Chitty, David W
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Molecular.

description: The cortex is formed through a series of well-organized processes by which neural progenitor cells proliferate, commit to different cell fates and differentiate to neuronal and glial cell types. These complex processes are regulated by a wide range of intrinsic and extrinsic factors, which include members of the bone morphogenetic protein (BMP) family and their receptors. Accumulating evidence suggests that BMP7, a factor clinically used to repair bone fracture and kidney failure, is involved in brain development by contributing to both neural induction and cell differentiation. In this study, the role of BMP7 in cortical neurogenesis was examined during embryonic development in mice. Specifically, neuronal differentiation was enhanced in cortical cultures following treatment with low concentration recombinant human BMP7, whereas higher concentrations enhanced glial differentiation. Comparative analysis of BMP receptor expression during cortical development indicated that activin receptor type IIB (ActRIIB) expression is significantly higher than other BMP receptors during neurogenesis, whereas it is significantly down-regulated following the onset of gliogenesis. Furthermore, the neutralization of ActRIIB in cortical cultures reduced levels of neuronal differentiation, suggesting its involvement in BMP7-induced cortical neurogenesis. Lastly, to further the study of BMP7, its signaling pathway and the downstream nuclear targets, lentiviral systems were developed and optimized to allow BMP7 overexpression and ActRIIB knockdown in the cortex. Similar to the commercially available recombinant BMP7, cortical neurogenesis was enhanced in the presence of lentiviral-derived BMP7.
Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: Wirtschaftliche Bewertung
Methylquecksilber

description: ABSTRACT:
BACKGROUND: Due to global mercury pollution and the adverse health effects of prenatal exposure to methylmercury (MeHg), an assessment of the economic benefits of prevented developmental neurotoxicity is necessary for any cost-benefit analysis.METHODS:
Distributions of hair-Hg concentrations among women of reproductive age were obtained from the DEMOCOPHES project (1,875 subjects in 17 countries) and literature data (6,820 subjects from 8 countries). The exposures were assumed to comply with log-normal distributions. Neurotoxicity effects were estimated from a linear dose-response function with a slope of 0.465 Intelligence Quotient (IQ) point reduction per mug/g increase in the maternal hair-Hg concentration during pregnancy, assuming no deficits below a hair-Hg limit of 0.58 mug/g thought to be safe. A logarithmic IQ response was used in sensitivity analyses. The estimated IQ benefit cost was based on lifetime income, adjusted for purchasing power parity.RESULTS:
The hair-mercury concentrations were the highest in Southern Europe and lowest in Eastern Europe. The results suggest that, within the EU, more than 1.8 million children are born every year with MeHg exposures above the limit of 0.58 mug/g, and about 200,000 births exceed a higher limit of 2.5 mug/g proposed by the World Health Organization (WHO). The total annual benefits of exposure prevention within the EU were estimated at more than 600,000 IQ points per year, corresponding to a total economic benefit between [euro sign]8,000 million and [euro sign]9,000 million per year. About four-fold higher values were obtained when using the logarithmic response function, while adjustment for productivity resulted in slightly lower total benefits. These calculations do not include the less tangible advantages of protecting brain development against neurotoxicity or any other adverse effects.CONCLUSIONS:
These estimates document that efforts to combat mercury pollution and to reduce MeHg exposures will have very substantial economic benefits in Europe, mainly in southern countries. Some data may not be entirely representative, some countries were not covered, and anticipated changes in mercury pollution all suggest a need for extended biomonitoring of human MeHg exposure.
Quelle: http://www.ncbi.nlm.nih.gov/pubmed/23289875
Community and identity in nineteenth century Montreal: The founding of Saint Patrick's Church.
Creators: name: Leitch, Gillian Irene.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: History, Church.

description: In 1817 Montreal's Catholic Church, under the direction of the Seminary of Saint Sulpice, granted English-language services to its Irish congregation. From that time on, the Irish of Montreal enjoyed services separate from the French Canadians. This separation was emphasized with the opening of Saint Patrick's Church in 1847, purpose-built for the Irish Catholics of Montreal. This thirty year period, understudied in relation to the city's Irish population, marks the time when the Irish of Montreal became a community, forging its identity within and without the Catholic Church. This identity was developed outside the Catholic Church through social organizations that attracted the ethnic Irish exclusively, such as the Hibernian Benevolent and Saint Patrick Societies, founded during this period. Cultural celebrations, notably those surrounding Saint Patrick's Day, were occasions where the community could share their traditions and celebrate their Irish heritage. These secular activities were not organized by the Roman Catholic Church in Montreal, but the Church was very involved. The Saint Patrick's Society included the clergy within its executive, while the cathedral of Notre Dame hosted the multi-denominational service held in honour of Saint Patrick. The interaction of the Irish Catholics and the Catholic Church is the primary focus of this thesis, as the community expressed itself within the institution often. (Abstract shortened by UMI.)
Dermatite atópica refratária: como conduzir?
Creators: name: Ranniery Caetano Sampaio Martins Frade
Publisher: name: Zenodo
Year: 2024

description: A dermatite atópica refratária é uma condição crônica e inflamatória da pele, caracterizada por um curso persistente e resposta inadequada aos tratamentos convencionais. Pacientes com esta forma de dermatite atópica enfrentam desafios significativos no manejo da doença, que impacta negativamente sua qualidade de vida. Este artigo revisa as abordagens mais eficazes para o tratamento de casos refratários, incluindo o uso de terapias imunomoduladoras avançadas, como os inibidores da JAK e biológicos. A revisão abrange as mais recentes evidências clínicas e diretrizes terapêuticas, oferecendo uma visão abrangente das estratégias disponíveis para otimizar o controle da doença e minimizar as exacerbações nesses pacientes.
Qualitative research with young men about sexual health
Creators: name: Knight, Rod E.
name: Chabot, Cathy
name: Shoveller, Jean
Publisher: name: The University of British Columbia
Year: 2018

description: Our Research Methods Case focuses on the topic of qualitative sexual health research with young men aged 15 to 30. We describe our experiences in designing and conducting qualitative research with young men, including how we choose and use methods and the challenges and benefits associated with these experiences. The methods and experiences we will describe include the process of attaining ethical approval from Human Subjects Committees to conduct research with young men (including young men under the age of majority) regarding: “controversial” issues such as sexual practices, sexuality, gendered power relations, and HIV criminalization; our experiences recruiting young men to participate in this type of research; how we designed and conducted semi-structured interviews about sexual health and young men; how we employed young men as peer-researchers in the research process; and our reflections on stereotypes regarding young men, including our own, and how we are using research to break down the stigma associated with ageism, hegemonic masculinity, and other forms of oppression.
Retocolite ulcerativa: etiologias e inovações terapêuticas
Creators: name: Ranniery Caetano Sampaio Martins Frade
Publisher: name: Zenodo
Year: 2024

description: A retocolite ulcerativa (RCU) é uma doença inflamatória intestinal crônica que afeta o cólon e o reto, caracterizada por inflamação contínua da mucosa. As etiologias da RCU são multifatoriais, envolvendo interações entre fatores genéticos, imunológicos e ambientais. O diagnóstico precoce é fundamental para o manejo eficaz, e as opções terapêuticas têm evoluído, incluindo novos agentes biológicos e terapias direcionadas, que oferecem esperança para o controle da doença. Este artigo revisa as principais causas da RCU, abordando também as inovações terapêuticas recentes. A conclusão destaca a importância de um tratamento personalizado para melhorar o prognóstico e a qualidade de vida dos pacientes.
The role of marital distress, parental and child depression, family functioning and health care behaviors in treatment adherence and metabolic control among adolescents with diabetes.
Creators: name: Champaigne, Lorraine Anne.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Health Sciences, Public Health.

description: Fifty-five adolescents with Type 1 diabetes, who were receiving secondary care services from diabetes clinics and pediatricians, were followed for three months in this exploratory community study. Measures of parental depression, marital distress, general family functioning, and diabetes-specific family functioning were obtained during an assessment of both parents and adolescent. The 24-hour recall adherence interviews were conducted separately with both the parent and adolescent on six occasions over the three months, and metabolic control was measured by HbA1c levels at the onset and end of the study. Multiple regression analyses showed that adherence was not associated with control. Adolescents who had been diagnosed longer were in worse metabolic control. Family relations were not linked with glycemic control and their influence varied on the five dimensions of adherence. The family relations variables, as a model, was significant in predicting diet amount adherence, accounting for 32.8% of the variance, with parental depression and general family conflict accounting for most of it. The family relations model was significant in predicting exercise adherence, with diabetes-specific guidance-control, accounting for 37.2% of the variance. Controlling for chronological age and gender, adolescent depression, as a measure of child adaptation, was not a significant predictor of glycemic control or adherence. However, both gender and chronological age accounted for 39.2% of exercise adherence. Glycemic control was consistent, with 75% of the adolescents displaying stable controlled and non-controlled metabolic control throughout the study. Metabolic control, treatment adherence and frequency of insulin omissions were similar for those receiving treatment from a diabetes clinic versus a pediatrician, Using an insulin sliding scale improved metabolic control, whereas adherence was similar for the groups. Males and females omitted insulin injections equally across the three adolescent age groupings and metabolic control was worse for those who missed insulin injections. Neither adherence nor family relations differentiated between the adolescents who missed or did not miss insulin injections. Parental involvement in the diabetes regime differed by gender, with parents remaining involved with females for longer. Results were discussed in the context of adolescent development and the systems social/ecological model of adaptation and coping developed by Kazak (1989).
Laser Doppler Assessment of Vasomotor Axon Reflex Responsiveness to Evaluate Neurovascular Function
Creators: name: Kubasch, Marie Luise
name: Kubasch, Anne Sophie
name: Pacheco, Juliana Torres
name: Buchmann, Sylvia J.
name: Illigens, Ben Min-Woo
name: Barlinn, Kristian
name: Siepmann, Timo
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: laser Doppler
subject: imaging
subject: flowmetry
subject: skin
subject: neuropathy
subject: assessment
subject: axon
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The vasomotor axon reflex can be evoked in peripheral epidermal nociceptive C-fibers to induce local vasodilation. This neurogenic flare response is a measure of C-fiber functional integrity and therefore shows impairment in patients with small fiber neuropathy. Laser Doppler flowmetry (LDF) and laser Doppler imaging (LDI) are both techniques to analyze vasomotor small fiber function by quantifying the integrity of the vasomotor-mediated axon reflex. While LDF assesses the flare response following acetylcholine iontophoresis with temporal resolution at a single defined skin point, LDI records flare responses with spatial and temporal resolution, generating a two-dimensional map of superficial blood flow. LDF is characterized by a high intra- and interindividual measurement variability, which is smaller in LDI due to its spatial resolution. Nevertheless, LDI still lacks standardized methods for image analysis. Consequently, use of the technique currently remains on an experimental level. Here, we sought to review the current literature on laser Doppler assessment of vasomotor function and discuss potential future applications of established techniques as well as those that are still experimental.
La musique religieuse d'Alexis Contant et son apport à la vie musicale de Montréal.
Creators: name: Leclerc, Gilles Maurice.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Religion, General.

description: Dans l'essor d'activites musicales que connai t Montreal, c'est par ses messes et oratorios qu'Alexis Contant, de formation entierement canadienne, se distingue des musiciens de son epoque. Apres un bref resume biographique de sa vie et un survol des influences musicales qui l'ont marque, on se penchera sur le repertoire liturgique a Montreal au tournant du siecle afin de preciser les oeuvres qu'accompagne Contant, organiste a l'eglise Saint-Jean-Baptiste de Montreal. Les oratorios Cain (1905) et Les Deux Ames (1909) d'Alexis Contant sont situes dans le renouveau que connai t le genre au cours de la deuxieme moitie du XIXe siecle. Alexis Contant est, au tournant du siecle, une figure importante de la vie musicale de Montreal, car il introduit a la composition quebecoise l'oratorio et le poeme symphonique, devenant ainsi un catalyseur de la creation musicale dans un milieu ou les activites culturelles s'etablissent peu a peu. Comme ses oeuvres religieuses lui ont assure une certaine renommee a Montreal, ce memoire porte aussi sur l'apport de Contant, a la vie musicale de son milieu. L'augmentation considerable de la population, dans les anees 1881 a 1901, attire des artistes europeens et americains. Les concerts symphoniques et les presentations d'operas occupent le devant de la scene musicale. A la suite des auditions de Cain et Les Deux Ames a la radio d'Etat en 1980 et en 1988, les critiques soulignent la contribution notable de Contant. C'est, en effet, grace a ces diffusions que ses oeuvres gagnent a nouveau l'attention des melomanes et des musiciens en quete de revoire le patrimoine musical canadien. (Abstract shortened by UMI.)
Analyse sociologique des intentions de la réforme du système éducatif Haïtien : réforme Bernard: 1979-1980.
Creators: name: Rosembert, Jacques.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Education, Sociology of.

description: Nous orientons spécifiquement cette recherche vers une analyse sociologique des intentions sous-jacentes à la réforme du système éducatif haïtien de 1979-80. Il s'agit de déterminer la place de cette nouvelle structure éducative dans la société haïtienne. Autrement dit, examiner l'attitude (caractère), vérifier la réalité de ce changement en fonction de ses finalités, de ses principes de base, de ses objectifs sociaux, éducatifs fondamentaux. Telles sont nos principales préoccupations. Cinq étapes guideront la présente recherche: Dans le premier chapitre, nous définirons la notion de réforme de l'éducation et nous l'exposerons comme objet de cette étude Dans le deuxième chapitre, nous esquisserons une analyse historique, idéologicoculturelle sur la formation de la société haïtienne en dégageant certains traits caractéristiques et en illustrant certaines tendances. Dans le troisième chapitre sur la crise de l'éducation, nous aborderons les différents éléments qui ont déclenché la démarche réformatrice. Dans le quatrième chapitre, sur les fondements de l'idéologie de la réforme éducative, nous présenterons les finalités, les principes de base, les objectifs et orientations sociaux, linguistiques, pédagogiques et techniques fondamentaux et toutes les options qui en découlent. Dans le cinquième chapitre, nous procéderons à l'analyse des intentions sous-jacentes à la réforme en tant que processus de développement ou blocage au changement. (Abstract shortened by UMI.)
Consumers, ALRC Privacy Principles and the 2010 Healthcare Identifiers Act
Creators: name: Heath, Jennifer
Publisher: name: Swinburne
Year: 2024

description: Aspects of the 2010 Healthcare Identifiers Act (HIA) are compared to the Australian Law Reform Commission (ALRC) Unified Privacy Principles. The opportunity for improved healthcare delivery through the enabling healthcare identifiers is acknowledged and discussion moves beyond such justifications to consideration of broader implications for Australian society. Law Academic Roger Magnusson's three broad, sequential conceptual shifts in health privacy provide a framework for the discussion. Lost opportunities for Australian consumers are also highlighted.
Evaporation of biomass pyrolysis oil as single droplets
Creators: name: Sari, Azra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Mechanical.

description: Biomass pyrolysis oil is an organic liquid produced by the pyrolysis of biomass materials. The fuel is known as a clean, cost-effective, renewable resource and a potential replacement for petroleum fuels in boiler, gas turbine, and diesel engine applications. The fuel oils are usually introduced into the burner as sprays of droplets; therefore, the evaporation behaviour of individual fuel droplet has an important role in understanding of the combustion characteristics of the droplets in spray combustion and in the burner performance. Single droplet evaporation/combustion experiments have been performed by several researchers in the past years with different kind of fuels by using two main techniques: Suspended droplet/moving furnace technique and freely falling droplet technique. In this research, the suspended droplet technique has been preferred because of its advantages that the droplet is stationary and easily observed. The mathematical model presented in this thesis is based on a model developed by Hallett and Clark (2006) to describe the evaporation of a pyrolysis oil droplet and its pyrolysis to gas and char. A well-mixed liquid phase is assumed in the previous model, which is reasonable owing to the vigorous bubbling during much of the evaporation process. However, this assumption is questionable during the pre-bubbling period. In order to gain some insight into this period, and into the onset and the location of bubbling, a diffusion-limited model, developed by Law and Law (1981) and extended by Hallett (2000) to a continuous mixture form, is used with some modifications to extend the earlier model. The results are compared to the experimental results, and conclusions for evaporation modelling are drawn.
An experimental study of wireless LANs
Creators: name: Sattari, Afsaneh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, System Science.

description: Wireless equipment based on IEEE 802.11 standard has been increasingly successful during the recent years. The popularity of wireless LAN hardware, and increasing use of different applications has brought challenges and competition among different vendors of IEEE 802.11 standards. Traditionally, such equipment has mainly been used indoors to allow users to wirelessly connect to the Internet or to a LAN. In this thesis we evaluate wireless equipment of the 802.11b standard. We consider typical scenarios and also consider typical transport protocols (i.e. TCP and UDP) in order to observe the performance of the system in real settings. Although the performance of a system mainly depends on the following metrics: throughput, packet loss, delay and jitter, in this thesis we take into consideration a large number of metrics of performance in order to obtain a better understanding of the way diverse factors impact performance in real wireless LANs. Indeed, we perform a large set of tests and measurements with different hardware. This let us obtain a more complete view of the performance of the system. Such parameters are important in real networks since its interrelation affect the quality of service perceived by various services carried by the network. We observe that real throughput of WLANs is sensibly lower than the raw amount usually advertised by the manufacturers. From the obtained results we conclude that in addition to the lack of efficiency of the MAC layer, this situation is also due to the combination of other factors that are detailed in the thesis. We found that one of the most important factor affecting the performance is a corner in the signal path between the sender and the receiver, which significantly affects the performance. We also describe some different hardware and software tools that are useful to carry out the tasks required for a performance study in a wireless LAN.
Filipina Caregivers and Domestic Workers in Southern Taiwan: Communities and Human Rights
Creators: name: O'Brian, Katie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Sociology, Ethnic and Racial Studies.
subject: Sociology, Social Structure and Development.

description: This thesis is an ethnographic explorative case study of Filipina caregivers and domestic workers in Taiwan, based on seven months of field research. It combines participant observation, interviews with Filipina household workers and migrant worker NGO representatives and church workers, and a review of written materials from these NGOs. Using Arjun Appadurai's (1996) theoretical framework on landscapes and the production of locality, it explores how Filipina household workers create locality in the production of transnational ethnoscapes, as well as how they demand the recognition of their rights within the transnational ideoscapes of human rights. I found that Filipinas create locality through the creation and use of Filipino spaces, including the Catholic Church, Filipino restaurants and shops, and public spaces likes parks. With respect to human rights, I found that Filipina household workers demand the recognition of their human rights through the assistance of the Church and migrant workers NGOs, but with limited success.
Initiation of delayed hydride cracking in zirconium-2.5 niobium.
Creators: name: Rodgers, Douglas Keith.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Mechanical.

description: Delayed Hydride Cracking (DHC) occurs in Zr-2.5Nb when certain requirements are met. The mechanism of DHC consists of diffusion of hydrogen to a stress concentrator, such as a crack-tip, precipitation then fracture of a hydride at the crack-tip, and repetition of the process; the crack advances in steps. Incubation times, to the start of cracking and crack-tip hydride morphologies have been measured in pre-cracked cantilever beam specimens tested at applied K$\rm\sb I$'s up to 20 MPam$\sp{1/2}$ and temperatures ranging from 100 to 250$\sp\circ$C. The incubation time for DHC was found to vary inversely with DHC velocity. Contrary to previous research, the incubation time is highly variable, even for a given temperature and applied K$\rm\sb I,$ and the crack-tip hydride morphology is much more complicated than the simple model of a single hydride at a crack-tip.
Negotiating violence in the context of transphobia and criminalization : the experience of trans sex workers in Vancouver, Canada
Creators: name: Lyons, Tara
name: Krüsi, Andrea
name: Pierre, Leslie
name: Kerr, Thomas
name: Small, Will
name: Shannon, K.
Publisher: name: Qualitative Health Research
Year: 2018

description: A growing body of international evidence suggests that sex workers face a disproportionate burden of violence, with significant variations across social, cultural, and economic contexts. Research on trans sex workers has documented high incidents of violence; however, investigations into the relationships between violence and social-structural contexts are limited. Therefore, the objective of this study was to qualitatively examine how social-structural contexts shape trans sex workers’ experiences of violence. In-depth semistructured interviews were conducted with 33 trans sex workers in Vancouver, Canada, between June 2012 and May 2013. Three themes emerged that illustrated how social-structural contexts of transphobia and criminalization shaped violent experiences: (a) transphobic violence, (b) clients’ discovery of participants’ gender identity, and (c) negative police responses to experiences of violence. The findings demonstrate the need for shifts in sex work laws and culturally relevant antistigma programs and policies to address transphobia.
Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells
Creators: name: Deiser, Katrin
name: Stoycheva, Diana
name: Bank, Ute
name: Blankenstein, Thomas
name: Schueler, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The adoptive transfer of antigen-specific CD8+ T cells is a promising approach for the treatment of chronic viral and malignant diseases. In order to improve adoptive T cell therapy (ATT) of cancer, recent strategies aim at the antibody-based blockade of immunosuppressive signaling pathways in CD8+ T cells. Alternatively, adjuvant effects of immunostimulatory cytokines might be exploited to improve therapeutic CD8+ T cell responses. For example, Interleukin-7 (IL-7) is a potent growth, activation and survival factor for CD8+ T cells that can be used to improve virus- and tumor-specific CD8+ T cell responses. Although direct IL-7 effects on CD8+ T cells were studied extensively in numerous models, the contribution of IL-7 receptor-competent (IL-7R+) host cells remained unclear. In the current study we provide evidence that CD8+ T cell-mediated tumor rejection in response to recombinant IL-7 (rIL-7) therapy is strictly dependent on IL-7R+ host cells. On the contrary, CD8+ T cell expansion is independent of host IL-7R expression. If, however, rIL-7 therapy and peptide vaccination are combined, host IL-7R signaling is crucial for CD8+ T cell expansion. Unexpectedly, maximum CD8+ T cell expansion relies mainly on IL-7R signaling in non-hematopoietic host cells, similar to the massive accumulation of dendritic cells and granulocytes. In summary, we provide evidence that IL-7R+ host cells are major targets of rIL-7 that modulate therapeutic CD8+ T cell responses and the outcome of rIL-7-assisted ATT. This knowledge may have important implications for the design and optimization of clinical ATT protocols.
Bestandsaufnahme zu den Auswirkungen von Fernbusreisen auf Verkehrsentwicklung und Emissionen in Deutschland
Creators: name: Bruns, Frank
name: Haan, Peter De
name: Bianchetti, Roberto
Publisher: name: My University
Year: 2018
Subjects: subject: Fernverkehr
subject: Fernlinienbus
subject: Fernbusverkehr
subject: Fernbus
subject: Fernlinienbusverkehr
subject: Fahrzeug-Emissionsklassifizierung
subject: Reisende
subject: Flottenzusammensetzung
subject: Verkehr

description: Durch die Liberalisierung des Fernbusverkehrs ist eine neue Verkehrsart in den Fernverkehrsmarkt der Personenbeförderung vorgedrungen. Die verkehrlichen Auswirkungen des Fernbusverkehrs und dessen Emissionsbilanz sind bislang noch weitgehend unbekannt. Ziel der Untersuchung ist es, Hinweise aufdas Verhalten der Fahrgäste,eine Einschätzung zur durchschnittlichen Schadstoffklasse der eingesetzten Fahrzeuge undzur Auslastung der Fernbusse zu erhalten.Die Untersuchung schließt mit einer Emissionsbilanz der Fernbusse unter Berücksichtigung des Verhaltens der Fahrgäste.
L'impact de la force numérique des femmes cadres sur le changement des attitudes à leur endroit.
Creators: name: Rinfret, Natalie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Women's Studies.

description: La situation minoritaire des femmes cadres de niveaux intermediaire et superieur dans les organismes publics et prives souleve de nombreux problemes auxquels on tente d'apporter remede par des mesures volontaires ou des programmes concertes. Dans la foulee des travaux de Kanter (1977), cette etude vise a verifier si les attitudes a l'egard des femmes cadres seraient d'autant plus favorables que leur nombre augmente. Par ailleurs, en tenant compte de l'etude de Harlan et Weiss (1981), les attitudes seraient moins favorables lorsque le nombre des cadres feminines atteindrait 20%. Deux etudes ont mis ces hypotheses a l'epreuve: une premiere en laboratoire et une seconde en milieu naturel. Des etudiant-e-s en administration (N = 187) ont reagi a des simulations faisant varier la force numerique des cadres feminines (9%, 20%, 35%, 50%). Les etudiant-e-s ont fait valoir, dans l'ensemble, des attitudes tres favorables a leur endroit, quelque soit leur nombre. Les attitudes de 354 gestionnaires federaux des deux sexes ont ete mesurees en fonction de quatre pourcentages: 9% et 20%, effectifs reels, 35% et 50%, effectifs hypothetiques. Pour cette etude, l'impact de la force numerique n'est conforme aux hypotheses qu'a 9% et 35%. A 20%, les attitudes sont plus favorables qu'a 9%, mais a 50%, elles sont semblables a celles obtenues a 9%. Les resultats suggerent que la proportion ideale serait de 35% et que les attitudes les plus favorables se retrouvent chez les femmes, les gestionnaires diplome-e-s dans les humanites et en administration, les plus jeunes et ceux-celles qui ont moins d'anciennete a la FPF. L'evaluation du statut des femmes cadres, de leur contribution a la culture organisationnelle et les attributions faites a leur endroit ne fluctuent pas parallelement a ces attitudes, ce qui fait ressortir des dimensions multiples du phenomene etudie. L'examen des processus psychologiques sous-jacents au changement des attitudes, a l'aide d'analyses des structures de causalite, ont revele des processus differentiels en fonction du sexe.
CR TKA UHMWPE Wear Tested after Artificial Aging of the Vitamin E Treated Gliding Component by Simulating Daily Patient Activities
Creators: name: Schwiesau, Jens
name: Fritz, Bernhard
name: Kutzner, Ines
name: Bergmann, Georg
name: Grupp, Thomas M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The wear behaviour of total knee arthroplasty (TKA) is dominated by two wear mechanisms: the abrasive wear and the delamination of the gliding components, where the second is strongly linked to aging processes and stress concentration in the material. The addition of vitamin E to the bulk material is a potential way to reduce the aging processes. This study evaluates the wear behaviour and delamination susceptibility of the gliding components of a vitamin E blended, ultra-high molecular weight polyethylene (UHMWPE) cruciate retaining (CR) total knee arthroplasty. Daily activities such as level walking, ascending and descending stairs, bending of the knee, and sitting and rising from a chair were simulated with a data set received from an instrumented knee prosthesis. After 5 million test cycles no structural failure of the gliding components was observed. The wear rate was with mg/million cycles falling within the limit of previous reports for established wear test methods.
Design, specification, and validation of telephony systems in LOTOS.
Creators: name: Boumezbeur, Rezki.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Computer Science.

description: LOTOS (Language Of Temporal Ordering Specification) is a Formal Description Technique (FDT) based on the temporal ordering of observational behaviour. It was developed by ISO (International Organization for Standardization) for the specification of OSI (Open Systems Interconnection) services and protocols. The topic of this thesis is first to present a Sample Telephone System, then formalize it using the FDT language LOTOS. The resulting LOTOS specification is then validated using an interpreter. Testing the design of the specification is also discussed. The thesis is structured as follows: in Chapter 1, we present an introduction to formal description techniques along with a review of some relevant existing work and the objective of this thesis. The next Chapter gives an overview of the LOTOS language. In Chapter 3, we discuss concepts of design of telecommunication systems. The Chapter includes an overview of telecommunication systems along with an informal description of a Sample Telephone System. In Chapter 4, we discuss the formal description in LOTOS of the Sample Telephone System presented in Chapter 3. Validation and testing of the specification are also part of Chapter 3. The conclusions of the thesis along with a discussion of possible future work follow in Chapter 5. Appendix A presents some technical abbreviations, and the Sample Telephone Specification is presented in Appendix B. In Appendix C, we present a set of test processes used to test the Sample Telephone Specification. Finally, some important symbolic trees of processes are presented in Appendix D.
Primäre und sekundäre Resistenzmechanismen der EGFR Blockade
Creators: name: Klinghammer, Konrad
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Cetuximab
subject: epidermal growth factor receptor
subject: cetuximab-docetaxel treatment
subject: squamous cell carcinoma of the head and neck
subject: head and neck cancer
subject: patient-derived xenograft models
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die Blockade des EGF Rezeptors ist fester Bestandteil in der Therapie von Kopf-Hals Plattenepithelkarzinomen. Trotz zahlreicher klinisch, translationaler und präklinischer Forschungen konnte bis zum heutigen Tag kein prädiktiver Biomarker für die Behandlung von Kopf-Hals Karzinomen validiert werden. Die dargestellten Arbeiten zeigen sehr gut die Chancen und gleichzeitig die Limitationen von translationaler Forschung mit dem Ziel der Definition prädiktiver Biomarker auf. Patientenproben sind in der Regel FFPE fixiert, bergen den Nachteil der z.T. langen Lagerung einhergehend mit Nukleinsäuredegradierung und sind nur für einen Teil interessanter Fragestellungen zu gebrauchen. Weiterhin findet in der Regel eine multimodale Behandlung statt, die den Stellenwert eines einzelnen biologischen Charakteristikums, wie in den Arbeiten beispielhaft an Amphiregulin oder EGFRvIII Expression gezeigt, in der Interpretation erschweren. Präklinische Modelle, die die Erkrankungssituation 1:1 widerspiegeln, gibt es nicht. Ein präklinisches Modell, dass nah am Ausgangstumor bleibt, ist das PDX Modell. Es konnte gezeigt werden, dass eine grosse Zahl von Kopf-Hals Tumor Xenograftmodellen sehr gut geeignet sind, Hypothesen zu generieren.
SURXON VOHASİDA XOTİN-QİZLAR SPORTİNİ RİVOJLANİSH TARİXİ VA İSTIQBOLLARİ
Creators: name: Muhammadıyeva, Nilufar
Publisher: name: Zenodo
Year: 2024

description: Ushbu tezisda Surxon vohasida xotin-qizlar sportining shakllanishi, voha xotin-qizlar sportining respublika miqyosidagi o’rni, xalqaro musobaqalarda voha qizlarining qo’lga kiritayotgan yutug’lari, Prezidentimizning xotin-qizlar sportiga berayotgan ulkan etiborlari, vohada o’tkazilayotgan xotin-qizlar o’rtasidagi musobaqalar ilmiy jihatdan tahlil etilgan. Surxondaryo viloyati xotin-qizlar sportiga berilayotgan etibor, voha sport majmualari ahvoli, xotin-qizlarni sport musobaqalariga jalb qilishdagi muammolarini hayotiy misollar bilan tushuntirishga harakat qilgan.
Stadtentwicklung in der Umweltforschung
Creators: name: Pipke, Larissa
Publisher: name: My University
Year: 2014
Subjects: subject: Stadtentwicklung
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Die Datenbank UFORDAT dokumentiert sowohl öffentlich geförderte Forschungsprojekte (Bund, Länder, Kommunen und EU) als auch privat finanzierte Forschung von Firmen, Stiftungen, Vereinen, Verbänden usw. Inzwischen geben über 100.000 Projektbeschreibungen von mehr als 10.000 forschenden Institutionen einen umfassenden Überblick auf das Forschungsgeschehen im Umweltbereich. Die Projektbeschreibungen umfassen u. a. Projekttitel, Kurzbeschreibung, Laufzeit, Institutionen, Projektleiter, Literatur, Internetlinks.
Person-centric integrated eHealth records: Reliable, secure, confidential and safe
Creators: name: Bennett, Janette
Publisher: name: Swinburne
Year: 2024

description: This article discusses two of the many eHealth implementations done by BT: the English National Programme for IT (NPfIT) and Hungary IKIR. BT has found that the interaction between patient and clinician and the needs and pressures of operational managers and policy makers are very similar in any country and setting. Any supporting technical solution, however, always requires contextualisation to the country's legal, financial, economic, demographic, geographic, technological and cultural landscape. There is no 'one size fits all' solution, but experience and lessons learnt are always reusable, especially in the areas of reliability, security, confidentiality and safety of information.
Clausal and verbal structure in Farsi.
Creators: name: Vahedi-Langrudi, Mohammad Mehdi.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Language, Linguistics.

description: This thesis intend to study very broadly and generally the verbal and clausal structure of the Farsi, the official language of the Islamic Republic of Iran. It tries to bring the clausal and verbal structure of Farsi language into the recent amendments of X-bar theory, i.e. the introduction of two different sets of categories, namely functional and lexical ones. We will use the principle and parameter model of generative grammar as our theoretical model of analysis. The verbal structure of the language will be analyzed based on the proposal of Pollock (1989), Chomsky (1989), and Ouhalla (1990), where it is argued that Infl constitutes of two sets of functional projections, namely AgrP and T(ense)P. Further separate projections are proposed for Negation and Auxiliaries. As far as X-bar theory is concerned, we will adopt a theory of X-bar which is least sophisticated and assumed to be more natural. We will adopt the theory of X-bar as proposed in Fukui and Speas (1986), Fukui (1986), and Speas (1990) among others which suggests that lexical items as well as functional ones project to a head, X0, and Xmax, and any number of intermediate iterable bars. The other constraints on the structure of phrases and clauses are imposed by other modules and subtheories of grammar. We will show that the phrasal structure of Farsi does in fact match this system. Word order in main and subordinate clauses will be studied and shown that it is constrained with Specificity of the elements as discussed in Karimi (1989), as well as case theory and directionality of head placement. The Ezafe Construction will be studied in Chapter III. I will argue that Ezafe, which is a clitic-like suffix similar to English of and French de has three different functions in the language. In chapter IV the structure of verb Phrases will be analyzed. We will see that the future auxiliary in Farsi is not a true auxiliary but a modal-like element which acts as a verb and subcategorizes for a subordinate main, lexical verb which causes the latter to incorporate into it at a higher level. Based on the function of negation in the language, we will also show that auxiliaries are base generated outside the projection of the verb. For the passives, we will argue that there are no real verbal passives in the language, rather passive constructions are adjectival formed in the lexicon. This is accounted for by the types of verb movements/raisings involved in the verbal structure, and the function and position of negation. Finally morphological causatives in Farsi will be brought in line with the "Incorporation" analysis of Baker (1988) and Li (1991).
Effects of subthalamic nucleus deep brain stimulation on emotional working memory capacity and mood in patients with Parkinson's disease
Creators: name: Merkl, Angela
name: Röck, Eva
name: Schmitz-Hübsch, Tanja
name: Schneider, Gerd-Helge
name: Kühn, Andrea A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: deep brain stimulation
subject: Parkinson’s disease
subject: working memory
subject: neuropsychiatric
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background: In Parkinson’s disease (PD), cognitive symptoms and mood changes may be even more distressing for the patient than motor symptoms. Objective: Our aim was to determine the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on working memory (WM) and mood. Methods: Sixteen patients with PD were assessed with STN-DBS switched on (DBS-ON) and with dopaminergic treatment (Med-ON) compared to switched off (DBS-OFF) and without dopaminergic treatment (Med-OFF). The primary outcome measures were a Visual Analog Mood Scale (VAMS) and an emotional 2-back WM task at 12 months after DBS in the optimal DBS-ON/Med-ON setting compared to DBS-OFF/Med-OFF. Results: Comparison of DBS-OFF/Med-OFF to DBS-ON/Med-ON revealed a significant increase in alertness (meanoff/off =51.59±24.54; meanon/on =72.75; P=0.016) and contentedness (meanoff/off =38.73±24.41; meanon/on =79.01±17.66; P=0.001, n=16), and a trend for reduction in sedation (P=0.060), which was related to stimulation as shown in a subgroup of seven patients. The N-back task revealed a significant increase in accuracy with DBS-ON/Med-ON compared to DBS-OFF/Med- OFF (82.0% vs 76.0%, respectively) (P=0.044), regardless of stimulus valence. Conclusion: In line with previous studies, we found that patients rated themselves subjectively as more alert, content, and less sedated during short- term DBS-ON. Accuracy in the WM task increased with the combination of DBS and medication, possibly related to higher alertness of the patients. Our results add to the currently mixed results described for DBS on WM and suggest that there are no deleterious DBS effects on this specific cognitive domain.
Aktivierung nichtnaturschutzrechtlicher Fachplanungsinstrumente und der räumlichen Gesamtplanung zur Umsetzung der Nationalen Biodiversitätsstrategie
Creators: name: Schütte, Peter
name: Kattau, Sandra
name: Koch, Annkatrin
Publisher: name: My University
Year: 2018
Subjects: subject: Ökologischer Korridor
subject: Raumplanung
subject: Fachplanung
subject: Umweltqualität
subject: Schutz der biologischen Vielfalt
subject: Lebensraumkorridor
subject: Umweltfachplanung
subject: Biodiversitätserhalt
subject: Planungsinstrumente
subject: Nachhaltigkeit | Strategien | Internationales

description: In dem Forschungsvorhaben wurde untersucht, wie nichtnaturschutzrechtliche Planungsinstrumente aus den Bereichen der Umweltfachplanungen, Fachplanungen anderer Sektoren sowie der räumlichen Gesamtplanung zur Sicherung, Verbesserung der Umweltqualität und angepassten Nutzung von Flächen der Lebensraumkorridore beitragen können. In der Studie werden sowohl akteursbezogene Potenziale als auch regelungsbezogene Verbesserungsmöglichkeiten aus Sicht der Bundesebene aufgezeigt.
A study of the river redhorse, Moxostoma carinatum (Pisces; Catostomidae), in the tributaries of the Ottawa River, near Canada's National Capital and in a tributary of Lake Ontario, the Grand River, near Cayuga, Ontario.
Creators: name: Campbell, Brent Gordon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Zoology.

description: This study provides baseline data on the River Redhorse (Moxostoma carinatum; Moxostomatini: Catostomidae) in Canada. Sampling focussed on the Mississippi and Gatineau Rivers, in the National Capital Region, in 1998 and 1999. Spawning occurred in rocky, shallow (<2m) fast-water sections in May and June when the temperature reached 17°C. In the Mississippi River, post-spawn specimens were captured on a variety of substrates in deeper waters. Both opercular bones and scales (n = 19) recorded accurate age until age XII after which only the opercular bone provided clear annuli. Growth for both sexes was defined by the following equation: total length at age (mm) = 0.0905 (age)3 - 5.1452 (age)2 + 95.94 (age) + 0.367. Population sizes were assessed through capture-recapture methods. The population size in the Mississippi River was estimated at 622 (+/-6.3 s.d.). The spawning population of the Gatineau River was estimated at 1216 (+/-915 s.d.). It is suggested that the species remains a species of "special concern" in Canada.