cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: EVALUATION OF THE NEED FOR CLINICIAN INVOLVEMENT IN THE DELIVERY OF AN APP-BASED INTERVENTION FOR OLDER ADULTS
title: A RANDOMIZED CLINICAL TRIAL
titleType: Subtitle
Creators: name: Chilton, Reanne
Publisher: name: Washington State University
Year: 2024
Subjects: Mobile Health app
Aging
Neuropsychology

description: The aging population is increasing while the caregiver pool is not. Assistive technologies can play a role in mitigating the effects of this aging wave on the healthcare industry. However, we must not only design technologies alongside the end-users, but also ensure the delivery of the technology maximizes its utility. This project sought to better understanding the effect of a clinician providing structured motivational support in uptake and integration of a new health app, the Electronic Memory and Management Aid (EMMA). While the app and the training system integrated in the app were thoughtfully designed to meet the needs of older adults, to understand the most effective way to deliver the app, we wanted to understand if it is most meaningfully offered as a stand-alone, or with a clinician in the loop. Forty-nine older adults with self-reported cognitive complaints were recruited to complete an adaptive web-based training program to learn to use and integrate the EMMA app into their daily life. During the training month, half of the study participants were randomly assigned to receive a weekly motivation and goal setting focused phone call from a clinician (M+T condition), while the other half completed the training independently (T condition) after initial set up sessions. Between group comparisons in app usage for the two-weeks post-training found that there were no differences in engagement with the app between the conditions. Correlational analyses revealed that motivation at baseline and throughout the training were significantly related to outcomes. This study helps inform effective delivery structures for technology-based interventions to support older adults aging in place.
A Practical Guide to Implementing Responsible Research Assessment at Research Performing Organizations
Creators: name: Allen, Liz
name: Barbour, Virginia
name: Cobey, Kelly
name: Faulkes, Zen
name: Hazlett, Haley
name: Lawrence, Rebecca
name: Lima, Giovanna
name: Massah, Flora
name: Schmidt, Ruth
Publisher: name: Declaration on Research Assessment (DORA)
Year: 2025
Subjects: research assessment
responsible research assessment
research performing organization
research culture
DORA
RRA

description: "A Practical Guide to Implementing Responsible Research Assessment at Research Performing Organizations" provides action-oriented guidance, resources, and illustrative examples, for research performing organizations (RPOs) who are looking to shape and deliver responsible research assessment (RRA) practices. This includes RPOs who are looking to create an RRA strategy, organizations wanting to reform existing practices, and organizations simply wanting to take steps towards more holistic and inclusive approaches to research assessment.

One approach to research assessment certainly does not fit all, so the Guide is intended to be an inspirational tool. It is discipline-agnostic, flexible, and is intended to be adaptable to diverse organizational and disciplinary contexts by users. We envision the Practical Guide being modified and updated over time - and especially being enriched with real examples and through feedback from research performing organizations as they start to use it.

The Practical Guide has been co-developed especially with interest holders who met January 31, 2025 in Maryland, USA, whose valuable contributions we thank. We also thank the helpful feedback from DORA Steering Committee Members Sean Sapcariu and Bernd Pulverer. We are grateful to Janet Catterall for her help in compiling and organizing the references and supporting resources mentioned in the Guide.

The Practical Guide has been created as part of Project TARA and, alongside Reformscape, the Building Blocks for Impact, and the Debiasing Committee Composition, forms a suite of tools designed to help organizations who are seeking to reform research assessment practices. Project TARA is supported by Arcadia, a family charitable foundation that helps people to record cultural heritage, to conserve and restore nature, and to promote open access to knowledge, whom we thank. Since 2002 Arcadia has awarded more than $1.2 billion to organizations around the world.

This publication is licensed under the Creative Commons Attribution-Noncommercial CC BY-NC. This information may be freely used, copied and adapted for non-commercial purposes, provided that the source is acknowledged.

Authors are ordered alphabetically by surname.
Examining the Syntax and Semantics of ASL MORE- and BEAT-constructions
Creators: name: Kentner, Ashley M
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Linguistic structures (incl. phonology, morphology and syntax)

description: Comparisons provide an important tool for exploring the syntax and semantics of gradable properties. American Sign Language (ASL) appears to have several such constructions, but they have yet to receive much linguistic analysis. This study establishes basic empirical facts concerning clausal boundaries, constituency structure, compatibility with various indicators for the presence of degrees, and composition of the standard of comparison for the MORE- and BEAT-construction in ASL. Such facts are needed for any formal syntactic or semantic treatment of the constructions. Motivated by typological observations, this study proposes that a reasonable set of initial hypotheses is that the ASL MORE-construction is a comparison of degrees and that the BEAT-construction is a comparison of individuals (as both terms are defined in Kennedy 2007). Results from the tests conducted in this study are largely consistent with those analyses, but also show where there is room for further refinement. Results additionally demonstrate that both more and beat qualify as explicit rather than implicit comparatives, confirming previous work in Wilbur et al. (2018) concerning the latter. An incidental finding of this study involves the distributional patterns fortwo modifiers frequently used with gradable properties, intensive aspect and Y-OO, indicating both have a semantics distinct from that of the English very even thoughfrequently translated between English and ASL with that modifier. Finally, this study contributes to the discussion of comparison constructions cross-linguistically by illustratingthe need to conduct cross-linguistic work that looks beyond what is considered the default comparison of the languages under investigation.
Additional file 1 of Extrapyramidal adverse events and anticholinergics use after the long-term treatment of patients with schizophrenia with the new long-acting antipsychotic Risperidone ISM®: results from matching-adjusted indirect comparisons versus once-monthly formulations of Paliperidone palmitate and Aripiprazole monohydrate in 52-week studies
Creators: name: Sánchez, Pedro
name: Álamo, Cecilio
name: Almendros, Marcos
name: Schlueter, Max
name: Tasoulas, Anastasios
name: Martínez, Javier
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1: Key characteristics of clinical trials identified for potential inclusion in the matching-adjusted indirect comparison. Table S2: Key trial inclusion and exclusion criteria. Table S3: Prognostic variable likelihood ratio test results for safety and tolerability outcomes in PRISMA-3 subgroups. Table S4: Detailed results of extrapyramidal symptoms safety base case outcome comparisons. Table S5: Detailed results of extrapyramidal symptoms safety outcome comparisons in the sensitivity analysis against Kane 2012. Table S6: Detailed results of anticholinergic agent use tolerability base case outcome comparisons. Table S7: Characteristics matching in Risperidone ISM versus Aripiprazole monohydrate once-monthly comparison, for the tolerability sensitivity analysis. Table S8: Detailed results of anticholinergic agent use in the tolerability outcome sensitivity analysis. Figure S1: Individual patient weights – Base case tolerability comparison to Gopal 2010. Figure S2: Individual patient weights – Base case tolerability comparison to Kane 2012. Figure S3: Individual patient weights – Sensitivity analysis tolerability comparison to Kane 2012.
sj-pdf-1-njn-10.1177_20571585211032774 - Supplemental material for Nurses’ experiences of simulation-based learning, 12–18 months after the simulation: A qualitative study
Creators: name: Solheim, Elisabeth
name: Flo, Jill
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-pdf-1-njn-10.1177_20571585211032774 for Nurses’ experiences of simulation-based learning, 12–18 months after the simulation: A qualitative study by Elisabeth Solheim and Jill Flo in Nordic Journal of Nursing Research
Portable platforms for molecular-based detection of pathogens in complex sample matrices
Creators: name: Moehling, Taylor J
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Biomedical engineering not elsewhere classified

description: Pathogen identification at the point of use is critical in preventing disease transmission and enabling prompt treatment. Current rapid diagnostic tests suffer from high rates of false negatives because they are not capable of detecting the inherently low concentrations of pathogens found in early stages of infection or in environmental reservoirs. The gold standard method for timely pathogen identification is a nucleic acid amplification assay called polymerase chain reaction. Although polymerase chain reaction is extremely sensitive and specific, it requires expensive laboratory equipment and trained personnel to perform the sample preparation, cyclical heating, and amplicon analysis. Isothermal nucleic acid amplification assays are better suited for field use because they operate at a single temperature and are robust to common sample matrix inhibitors. Thus, there is a need to translate isothermal amplification assays to the point of use for rapid and sensitive detection of pathogens in complex samples.
Here, I outline an approach to bring laboratory-based sample preparation, assays, and analyses to the point of use via portable platforms. First, I characterize a loop-mediated isothermal amplification assay and combine it with lateral flow immunoassay for simple, colorimetric interpretation of results. Next, I optimize an ambient-temperature reagent storage method to eliminate cold-chain requirements and precision pipetting steps. I then incorporate loop-mediated isothermal amplification, lateral flow immunoassay, and reagent drying into two different integrated paperfluidic platforms and demonstrate their ability to separately detect bacteria and viruses in complex sample matrices. Finally, I couple loop-mediated isothermal amplification with particle diffusometry to optically determine pathogen presence by tracking the Brownian motion of particles added to an amplified sample. The combined loop-mediated isothermal amplification and particle diffusometry method is first characterized on a microscope and then translated to a smartphone-based platform. Each of these portable platforms are broadly applicable because they can be easily modified for identification of other pathogens at the point of use.
The Role of PGC-1a Overexperssion in Skeletal Muscle Exosome Biogenesis and Secretion
Creators: name: Middleton, Derek M
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Exercise physiology

description: Skeletal muscle functions as an endocrine organ. Exosomes, small vesicles containing mRNAs, miRNAs, and proteins, are secreted from muscle cells and facilitate cell-to-cell communication. Our recent work found greater exosome release from oxidative compared to glycolytic muscle. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a key driver of mitochondrial biogenesis, a characteristic of oxidative muscle. It was hypothesized that PGC1α regulates exosome biogenesis and secretion in skeletal muscle. The purpose of this study is to determine if PGC-1α regulates skeletal muscle exosome biogenesis and secretion. On day 4 of differentiation, human primary myotubes from vastus lateralis biopsies from lean donors (BMI < 25.0 kg/m2) were exposed to adenovirus encoding human PGC-1α or GFP control. On day 6 of differentiation, culture media was replaced with exosome-free media. On day 8, cells were collected for mRNA and protein analysis, and culture media was collected for exosome isolation. Overexpression of PGC-1α increases regulators of exosome biogenesis in the endosomal sorting complexes required for transport (ESCRT) pathway: Alix (CON: 1.0 ± 0.2 vs. PGC-1α: 7.6 ± 3.8), TSG-101 (CON: 1.0 ± 0.1 vs. PGC-1α: 7.3 ± 2.1), CD63 (CON: 1.0 ± 0.17 vs. PGC-1α: 3.7 ± 0.4), Clathrin (CON: 1.0 ± 0.2 vs. PGC-1α: 11.6 ± 2.5), and the secretion pathway: Rab27b (CON: 1.0 ± 0.3 vs. PGC-1α: 3.2 ± 0.3), STAM (CON: 1.0 ± 0.3 vs. PGC-1α: 7.3 ± 0.6), and VTA1 (CON: 1.0 ± 0.1 vs. PGC-1α: 7.3 ± 2.4). Exosome count and total extracellular vesicle count were not significantly different from control. Overexpression of PGC-1α increases gene 9 expression of regulators of exosome biogenesis and secretion in human primary myotubes. In the future, in vitro studies assessing exosomal content from PGC-1 OE cells as well as in vivo effects of PGC-1 OE on exosome production and release should be investigated to further understand the role PGC-1 plays in exosome secretion.
Additional file 2 of Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
Creators: name: Wang, Gang
name: Liu, Hua-yue
name: Meng, Xiao-wen
name: Chen, Ying
name: Zhao, Wei-ming
name: Li, Wen-ting
name: Xu, Han-bing
name: Peng, Ke
name: Ji, Fu-hai
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S1. Characteristics of weight, blood gas, and electrolytes of mice.
sj-pdf-1-trc-10.1177_19400829211032585 - Supplemental material for Understanding Drivers of Unsustainable Natural Resource Use in the Comoro Islands
Creators: name: Ibouroi, Mohamed Thani
name: Dhurham, Said Ali Ousseni
name: Besnard, Aurélien
name: Lescureux, Nicolas
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Geography
subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-1-trc-10.1177_19400829211032585 for Understanding Drivers of Unsustainable Natural Resource Use in the Comoro Islands by Mohamed Thani Ibouroi, Said Ali Ousseni Dhurham, Aurélien Besnard and Nicolas Lescureux in Tropical Conservation Science
EVOLUTION OF SMARTPHONES METAL CONTENT WITH ITS FAST-IMPROVING FUNCTIONALITIES
Creators: name: Tantawi, Omar N
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Environmental engineering not elsewhere classified

description: Smartphones, one of the most common consumer electronic devices, are an essential part of daily activities in modern society. Smartphones provide faster communication, easier access to information and many other important services. However, with a compressed product life cycle and growing consumer demand, a significant number of smartphones reach End-of-Life (EoL) annually. At the same time, due to many special physical properties, rare earth, critical and other important metals are essential for the manufacturing of smartphones. Hence, from various economic, resources availability and environmental perspectives, it is crucial to understand how metal content of different smartphones generations change over time. To this end, a high production smartphone series, produced between 2010 and 2015 were considered in the scope of this study. The devices were disassembled, sorted into different components and size reduced. Printed circuit boards assembly, back cameras and NFC antenna/wireless charging chips were then digested using a novel microwave assisted acid digestion method. Inductively Coupled Plasma-Optical Emission Spectroscopy was used to detect and quantify 60 elements. Obtained results indicate that up to 70% of different smartphones components by weight are important recyclable metals. The highest concentration elements, Cu, Ni, Sn, Zn and Fe, accounted for 93.3% while REEs and PGMs collectively accounted for 0.53% of the total recoverable elements by weight. In 2019, the total addressable market value of metals reclamation from only three smartphone components at their end of life is estimated at 298.69 million USD in USA. Gold and Platinum were determined to be the most environmentally critical elements and efforts should made to reduce their use. Finally, and most importantly, smartphones manufacturers should design their products with an extended lifetime due to the high concentration of critical elements used to make them.
Additional file 1 of The impact of housing prices on residents’ health: a systematic review
Creators: name: Grewal, Ashmita
name: Hepburn, Kirk J.
name: Lear, Scott A.
name: Adshade, Marina
name: Card, Kiffer G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Supplementary Material 1.
Semantic Labeling of Large Geographic Areas Using Multi-Date and Multi-View Satellite Images and Noisy OpenStreetMap Labels
Creators: name: Comandur Jagannathan Raghunathan, Bharath Kumar
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Knowledge representation and reasoning
Computer vision
Photogrammetry and remote sensing
Artificial intelligence not elsewhere classified

description: This dissertation addresses the problem of how to design a convolutional neural network (CNN) for giving semantic labels to the points on the ground given the satellite image coverage over the area and, for the ground truth, given the noisy labels in OpenStreetMap (OSM). This problem is made challenging by the fact that -- (1) Most of the images are likely to have been recorded from off-nadir viewpoints for the area of interest on the ground; (2) The user-supplied labels in OSM are frequently inaccurate and, not uncommonly, entirely missing; and (3) The size of the area covered on the ground must be large enough to possess any engineering utility. As this dissertation demonstrates, solving this problem requires that we first construct a DSM (Digital Surface Model) from a stereo fusion of the available images, and subsequently use the DSM to map the individual pixels in the satellite images to points on the ground. That creates an association between the pixels in the images and the noisy labels in OSM. The CNN-based solution we present yields a 4-8% improvement in the per-class segmentation IoU (Intersection over Union) scores compared to the traditional approaches that use the views independently of one another. The system we present is end-to-end automated, which facilitates comparing the classifiers trained directly on true orthophotos vis-`a-vis first training them on the off-nadir images and subsequently translating the predicted labels to geographical coordinates. This work also presents, for arguably the first time, an in-depth discussion of large-area image alignment and DSM construction using tens of true multi-date and multi-view WorldView-3 satellite images on a distributed OpenStack cloud computing platform.
Exploring Culturally Informed AI Assistants: A Comparative Study of ChatBlackGPT and ChatGPT
Creators: name: Egede, Lisa
name: Haque, Ebtesam Al
name: Thompson, Gabriella
name: Boyd, Alicia
name: Smith, Angela D. R.
name: Johnson, Brittany
Publisher: name: arXiv
Year: 2025
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: In recent years, we have seen an influx in reliance on AI assistants for information seeking. Given this widespread use and the known challenges AI poses for Black users, recent efforts have emerged to identify key considerations needed to provide meaningful support. One notable effort is the development of ChatBlackGPT, a culturally informed AI assistant designed to provide culturally relevant responses. Despite the existence of ChatBlackGPT, there is no research on when and how Black communities might engage with culturally informed AI assistants and the distinctions between engagement with general purpose tools like ChatGPT. To fill this gap, we propose a research agenda grounded in results from a preliminary comparative analysis of outputs provided by ChatGPT and ChatBlackGPT for travel-related inquiries. Our efforts thus far emphasize the need to consider Black communities' values, perceptions, and experiences when designing AI assistants that acknowledge the Black lived experience.
description: 9 pages, 3 figures, Camera-ready Extended Abstract paper accepted into CHI 2025
EXPLORING PHISHING SUSCEPTIBILITY ATTRIBUTABLE TO AUTHORITY, URGENCY, RISK PERCEPTION AND HUMAN FACTORS
Creators: name: Tiwari, Priyanka
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Human-computer interaction
Social and community informatics

description: Security breaches nowadays are not limited to technological orientation. Research in the information security domain is gradually shifting towards human behavioral orientation toward breaches that target weaknesses arising from human behaviors (Workman et al., 2007). Currently, social engineering breaches are more effective than many technical attacks. In fact, the majority of cyber assaults have a social engineering component. Social Engineering is the art of manipulating human flaws towards a malicious objective (Breda et al., 2017). In the likely future, social engineering will be the most predominant attack vector within cyber security (Breda et al., 2017). Human failures, persuasion and social influences are key elements to understand when considering security behaviors. With the increasing concerns for social engineering and advancements in human factors-based technology, phishing emails are becoming more prevalent in exploiting human factors and external factors. Such factors have been researched upon in pairs, not overall. Till date, there is not much research done to identify the collaborative links between authority, urgency, risk perception and human factors such as personality traits, and knowledge. This study investigates about phishing email characters, external influences, human factors influences, and their collaborative effects.
Corpus Based Methods For Learning Models Of Metaphor In Modern Greek
Creators: name: Pechlivanis Konstantinos
Publisher: name: Zenodo
Year: 2017
Subjects: metaphor detection, natural language processing, information extraction, feature extraction, text mining, distributional semantics, machine learning, crawling, topic, categorization, annotation, term weighting, term frequency, inverse term frequency, document frequency, maximum likelihood, classification

description: In this thesis, we propose a method for detecting metaphorical usage of content terms

based on the hypothesis that metaphors can be detected by being characteristic of a

different domain than the one they appear in. We formulate the problem as one of

extracting knowledge from text classification models, where the latter have been created

using standard text classification techniques without any knowledge of metaphor. We

then extract from such models a measure of how characteristic of a domain a term is,

providing us with a reliable method of identifying terms that are surprising for the context

within which they are used.

In order to investigate our research proposal we started with compiling-crawling a

corpus of articles from three Greek newspapers that offer content on-line. In order to have

an initial classification, we mapped the sections of these three newspapers to domains from

the top level of the relevant taxonomy of the IPTC. The training set is only annotated

with the broad thematic categories assigned by the newspapers’ editors.

In order to evaluate our method, we have manually annotated 89 articles with metaphor-

ical term usage. The manual annotation was carried out by an initial annotator, with an

expert annotator resolving inconsistencies to create the golden corpus. The annotation

task was designed and elaborated using Ellogon platform.

In our experiment, we report results using Term Frequency - Inverse Document Fre-

quency (TF-IDF) to identify the literal (characteristic) domain of terms and we also

analyse the interaction between TF-IDF and other typical word features, such as Part of

Speech tags and Document Frequency. Term could be word or N-gram. The classification

of terms is applied using an adapted version of Maximum Likelihood Classifier.

Our method makes single-term binary decisions about metaphorical usage. We ap-

plied Precision, Recall and F 1 -score as evaluation metrics. We compared our system

with a naive baseline and the relevant work as well. Although, our model seems to be

over-general, producing many false positives, the overall F 1 -score outperforms both the

baseline and related previous work.
Gene epistasis influences metabolism of Saccharomyces Cerevisiae
Creators: name: Velasquez Zapata, Valeria
name: Bhandary, Priyanka
Publisher: name: Zenodo
Year: 2024

description: Epistasis, the interaction of genes in a non-additive manner is crucial for understanding changes in gene expression. By using public data from yeast metabolic mutants we explored the effect of epistasis in metabolism. By employing additive models as a null hypothesis, we analyzed differential gene expression in double mutants compared to single mutants and wild-type strains to isolate epistatic interactions. Specifically, we focused on genes differentially expressed in HL double mutants, which were not explained by single mutants H or L. Our analyses, which integrated metabolomics, proteomics, and transcriptomics data, identified a set of candidate genes affected by epistatic interactions. These genes were characterized through protein-protein interaction networks and gene regulatory networks, revealing notable correlations and structural differences at the proteomics level. Principal Component Analysis (PCA) and Partial Least Squares (PLS) indicated variable reproducibility in metabolomics data, but a strong explanatory power for epistatic genes relative to the transcriptome.
sj-pdf-1-crd-10.1177_14799731211035822 – Supplemental Material for Relationships between prolonged physical and social isolation during the COVID-19 pandemic, reduced physical activity and disability in activities of daily living among people with advanced respiratory disease
Creators: name: Fettes, Lucy
name: Bayly, Joanne
name: de Bruin, Leonora Michelle
name: Patel, Malini
name: Ashford, Stephen
name: Higginson, Irene J
name: Maddocks, Matthew
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-crd-10.1177_14799731211035822 for Relationships between prolonged physical and social isolation during the COVID-19 pandemic, reduced physical activity and disability in activities of daily living among people with advanced respiratory disease by Lucy Fettes, Joanne Bayly, Leonora Michelle de Bruin, Malini Patel, Stephen Ashford, Irene J Higginson and Matthew Maddocks in Chronic Respiratory Disease
Additional file 1 of A preliminary, quantitative study on the use of traditional and complementary medicine by cancer patients seen at the Senkatana oncology clinic, Maseru, Lesotho
Creators: name: Sooro, Mopa A.
name: Thoahlane, Thabo S.
name: Ramathebane, Maseabata V.
name: Mputsoe, Kabelo A.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer
Science Policy

description: Supplementary Material 1: Questionnaire on the use of complementary medicine by cancer patients in Lesotho
PLANT TAXA AND PYROLYSIS TEMPERATURE CONTROLS OF MICROBIAL AMINO SUGARS IN A NORTHERN FOREST SOIL
Creators: name: Kastenbauer, Jacob E
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Carbon sequestration science
Soil sciences not elsewhere classified
Soil biology

description: In fire-prone forests, tree taxa and burn temperature are the major controllers of the chemical and physical properties of pyrogenic organic matter (PyOM), the aromatic carbon-rich product of the incomplete combustion of plant biomass, that accumulates in soil in such settings. These controls also dictate how soil microbes can degrade plant C once it enters into soil as previous studies demonstrate that increased fire temperature results in low PyOM degradability but also impacts the decomposition of the original soil. However, we know little about how taxa and temperature of C-inputs impact the production and accumulation of cellular residues from soil microbes, which can be the dominant source of stabilized soil organic matter in many ecosystems. This work presents the results of the analysis of soil microbial amino sugars, as proxies for soil microbial necromass, from long-term soil incubation experiments, 180 and 600 days, that were amended with jack pine (JP) and red maple (RM) wood or their PyOM produced at 300°C or 450°C. Both wood taxa amendments resulted in an increase in microbial sugar residues compared to non-amended soils but RM, the taxa with the highest proportion of soluble sugars and low tannin content, exhibited the highest percentage increase. Soils amended with PyOM exhibited lower amino sugar content as compared to their wood but no difference compared to controls (non-amended soils). There was no difference in soil amino sugars observed between the PyOM derived from the two taxa nor between the temperature of pyrolysis, possibly due to only small amounts of bioavailable C and N in the PyOM. Total amino sugar concentrations varied significantly between PyOM and fresh wood treatments, with PyOM treatments yielding 659 – 730 μg/ g soil while wood treatments yielded 757 – 930 μg/ g soil early in incubations. While fungal-derived amino sugars were dominated in all treatments, longer soil incubation time, 600 days vs 180 days, resulted in a proportionately greater decrease bacterial-derived amino sugars. Overall, at 180 days, PyOM treatments exhibited 19-27% of soil N and 4-5% of soil C quantifiable as amino sugars while wood treatments exhibited 27-28% of total soil N and 6-7% of total soil C as amino sugars. This work shows, for the first time, that on a per C or per N basis, PyOM versus fresh wood addition to soils will result in a net depletion of microbial residues. The variable response in amino sugars between treatments and incubation time highlights the importance and dynamic nature of the physicochemical characteristics of organic matter input to soil in controlling the contribution of soil microbial residues to that soil.
Additional file 1 of Target trial emulation with multi-state model analysis to assess treatment effectiveness using clinical COVID-19 data
Creators: name: Martinuka, Oksana
name: Hazard, Derek
name: Marateb, Hamid Reza
name: Maringe, Camille
name: Mansourian, Marjan
name: Rubio-Rivas, Manuel
name: Wolkewitz, Martin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Table 1. A summary of protocol components for the target trial emulation. Table 2. Example of the structure of the data set used for multi-state analysis in the non-X-treated arm. Table 3. Baseline characteristics for eligible patients according to X-treatment receive within 5-days before cloning and censoring, complete dataset with missing value imputation, n=599. Table 4. Baseline characteristics for eligible patients according to categorization of 5-day grace period before cloning. Fig. 1. Example of target trial emulation with cloning and censoring for COVID-19 patients. Fig. 2. Multi-state model for COVID-19 progression, complete dataset with missing value imputation, n=599. Fig. 3. Covariate balance using standardised mean differences at five day grace period before and after applying inverse probability of artificial censoring weighting. Fig. 4. Covariate balance using standardised mean differences at five day grace period before and after applying inverse probability of artificial censoring weighting, complete dataset with missing value imputation, n=599. Fig. 5. Weighted estimated cause-specific cumulative hazards from the normal hospital ward using the Nelson-Aalen estimator, complete dataset with missing value imputation, n=599. Fig. 6. Weighted results for transition rates starting from hospital admission, complete dataset with missing value imputation, n=599.
YURAK ISHEMIK KASALIGI VA GIPERTONIYA
Creators: name: Maripjonov, Jasurbek
name: Mamatisaqova, Nilufarxon
name: Tursunova, Madinabonu
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada Yurak ishemik kasalligi va Gipertoniya kasaliglarining kelib chiqish sabablari to’liqroq yoritildi.  Hozrigi kunda aholimiz o’rtasida ayniqsa,  yoshi 40 yoshdan oshgan insonlarda ushbu kassaliklar ko’p uchramoqda. Yurak ishemik kasalligi va Gipertoniya kasaliklarining kelib chiqishi va rivojlanishiga kishilarning yoshi, kasallikka irsiy moyillik, qandli diabet, , spirtli ichimliklar istemol qilish, chekish, kamharakatlilik va ruhiy hamda jismoniy zo’riqish kabi holatlar sabab bo’lishi mumkin.
Additional file 1 of A methodological protocol for the development of a national guideline on perioperative management of gastrointestinal tumors in Germany
Creators: name: Willis, M. A.
name: Post, S.
name: Nothacker, M.
name: Follmann, M.
name: Langer, T.
name: Vilz, T. O.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. List of the working groups with the respective PICO questions
Strategies for Low-Thrust Transfer Design Based on Direct Collocation Techniques
Creators: name: Pritchett, Robert E
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Aerospace engineering not elsewhere classified

description: In recent decades the revolutionary possibilities of low-thrust electric propulsion have been demonstrated by the success of missions such as Dawn and Hayabusa 1 and 2. The efficiency of low-thrust engines reduces the propellant mass required to achieve mission objectives and this benefit is frequently worth the additional time of flight incurred, particularly for robotic spacecraft. However, low-thrust trajectory design poses a challenging optimal control problem. At each instant in time, spacecraft control parameters that minimize an objective, typically propellant consumption or time of flight, must be determined. The characteristics of low-thrust optimal solutions are often unintuitive, making it difficult to develop an a priori estimate for the state and control history of a spacecraft that can be used to initialize an optimization algorithm. This investigation seeks to develop a low-thrust trajectory design framework to address this challenge by combining the existing techniques of orbit chaining and direct collocation. Together, these two methods offer a novel approach for low-thrust trajectory design that is intuitive, flexible, and robust.
This investigation presents a framework for the construction of orbit chains and the convergence of these initial guesses to optimal low-thrust solutions via direct collocation. The general procedure is first demonstrated with simple trajectory design problems which show how dynamical structures, such as periodic orbits and invariant manifolds, are employed to assemble orbits chains. Following this, two practical mission design problems demonstrate the applicability of this framework to real world scenarios. An orbit chain and direct collocation approach is utilized to develop low-thrust transfers for the planned Gateway spacecraft between a variety of lunar and libration point orbits (LPOs). Additionally, the proposed framework is applied to create a systematic method for the construction of transfers for the Lunar IceCube spacecraft from deployment to insertion upon its destination orbit near the Moon. Three and four-body dynamical models are leveraged for preliminary trajectory design in the first and second mission design applications, respectively, before transfers are transitioned to an ephemeris model for validation. Together, these realistic sample applications, along with the early examples, demonstrate that orbit chaining and direct collocation constitute an intuitive, flexible, and robust framework for low-thrust trajectory design.
Genetic and biological architecture of pork quality, carcass, primal-cut and growth traits in Duroc pigs
Creators: name: Willson, Hannah E
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Animal reproduction and breeding

description: Within the last few decades, swine breeding programs have been refined to include pork quality and novel carcass traits alongside growth, feed efficiency, and carcass leanness in the selection programs for terminal sire lines with a goal to produce high quality and efficient pork product for consumers. In order to accurately select for multiple traits at once, it becomes imperative to explore their genetic and biological architecture. The genetic architecture of traits can be explored through the estimation of genetic parameters, genome-wide association studies (GWAS), gene networks and metabolic pathways. An alternative approach to explore the genetic and biological connection between traits is based on principal component analysis (PCA), which generates novel “pseudo-phenotypes” and biological types (biotypes). In this context, the main objective of this thesis was to understand the genetic and biological relationship between three growth, eight conventional carcass, 10 pork quality, and 18 novel carcass traits included in two studies. The phenotypic data set included 2,583 records from female Duroc pigs from a terminal sire line. The pedigree file contained 193,764 animals and the genotype file included 21,344 animals with 35,651 single nucleotide polymorphisms (SNPs). The results of the first study indicate that genetic progress can be achieved for all 39 traits. In general, the heritability estimates were moderate, while most genetic correlations were generally moderate to high and favorable. Some antagonisms were observed but those genetic correlations were low to moderate in nature. Thus, these relationships can be considered when developing selection indexes. The second study showed that there are strong links between traits through their principal components (PCs). The main PCs identified are linked to biotypes related to growth, muscle and fat deposition, pork color, and body composition. The PCs were also used as pseudo-phenotypes in the GWAS analysis, which identified important candidate genes and metabolic pathways linked to each biotype. All of this evidence links valuable variables such as belly, color, marbling, and leanness traits. Our findings greatly contribute to the optimization of genetic and genomic selection for the inclusion of valuable and novel traits to improve productive efficiency, novel carcass, and meat quality traits in terminal sire lines.
FEED-FORWARD NEURAL NETWORK (FFNN) BASED OPTIMIZATION OF AIR HANDLING UNITS: A STATE-OF-THE-ART DATA-DRIVEN DEMAND-CONTROLLED VENTILATION STRATEGY
Creators: name: MOMENI, SAYEDMOHAMMADMA VAEZ
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mechanical engineering not elsewhere classified
Electrical engineering not elsewhere classified

description: Heating, ventilation and air conditioning systems (HVAC) are the single largest consumer of energy in commercial and residential sectors. Minimizing its energy consumption without compromising indoor air quality (IAQ) and thermal comfort would result in environmental and financial benefits. Currently, most buildings still utilize constant air volume (CAV) systems with on/off control to meet the thermal loads. Such systems, without any consideration of occupancy, may ventilate a zone excessively and result in energy waste. Previous studies showed that CO2-based demand-controlled ventilation (DCV) methods are the most widely used strategies to determine the optimal level of supply air volume. However, conventional CO2 mass balanced models do not yield an optimal estimation accuracy. In this study, feed-forward neural network algorithm (FFNN) was proposed to estimate the zone occupancy using CO2 concentrations, observed occupancy data and the zone schedule. The occupancy prediction result was then utilized to optimize supply fan operation of the air handling unit (AHU) associated with the zone. IAQ and thermal comfort standards were also taken into consideration as the active constraints of this optimization. As for the validation, the experiment was carried out in an auditorium located on a university campus. The results revealed that utilizing neural network occupancy estimation model can reduce the daily ventilation energy by 74.2% when compared to the current on/off control.
sj-pdf-3-jah-10.1177_08982643211037200 – Supplemental Material for Socioeconomic Position and Late-Onset Dementia: A Nationwide Register-Based Study
Creators: name: Appel, Andreas M.
name: Brønnum-Hansen, Henrik
name: Garde, Anne H.
name: Hansen, Åse Marie
name: Ishtiak-Ahmed, Kazi
name: Islamoska, Sabrina
name: Mortensen, Erik L.
name: Osler, Merete
name: Nabe-Nielsen, Kirsten
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-3-jah-10.1177_08982643211037200 for Socioeconomic Position and Late-Onset Dementia: A Nationwide Register-Based Study by Andreas M. Appel, Henrik Brønnum-Hansen, Anne H. Garde, Åse Marie Hansen, Kazi Ishtiak-Ahmed, Sabrina Islamoska, Erik L. Mortensen and Kirsten Nabe-Nielsen in Journal of Aging and Health
Additional file 1 of A scoping review of risk factors for urinary incontinence in older men
Creators: name: Olagundoye, Olawunmi
name: Odusanya, Benjamin
name: Kung, Janice Y.
name: Gibson, William
name: Wagg, Adrian
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Additional file 1: APPENDICES: Search strategies, data extraction form and PRISMA-ScR checklist.
Additional file 1 of A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease
Creators: name: Choi, Alexander H.
name: Delgado, Melanie
name: Chen, Kong Y.
name: Chung, Stephanie T.
name: Courville, Amber
name: Turner, Sara A.
name: Yang, Shanna
name: Airaghi, Kayla
name: Dustin, Irene
name: McGurrin, Patrick
name: Wu, Tianxia
name: Hallett, Mark
name: Ehrlich, Debra J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Supplementary Material 1.
sj-pdf-3-pss-10.1177_0956797620903113 – Supplemental material for Bilingualism Affords No General Cognitive Advantages: A Population Study of Executive Function in 11,000 People
Creators: name: Nichols, Emily S.
name: Wild, Conor J.
name: Stojanoski, Bobby
name: Battista, Michael E.
name: Owen, Adrian M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-pdf-3-pss-10.1177_0956797620903113 for Bilingualism Affords No General Cognitive Advantages: A Population Study of Executive Function in 11,000 People by Emily S. Nichols, Conor J. Wild, Bobby Stojanoski, Michael E. Battista and Adrian M. Owen in Psychological Science
Additional file 1 of Measuring time in buprenorphine treatment stages among people with HIV and opioid use disorder by retention definition and its association with cocaine and hazardous alcohol use
Creators: name: Pytell, Jarratt D.
name: Fojo, Anthony T.
name: Keruly, Jeanne C.
name: Snow, LaQuita N.
name: Falade-Nwulia, Oluwaseun
name: Moore, Richard D.
name: Chander, Geetanjali
name: Lesko, Catherine R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Figure S1. Depiction of treatment buprenorphine treatment states for each of the retention definitions.