cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Life in the hands of welfare bureaucracy: the impact of austerity on disabled people in Sweden
Creators: name: Norberg, Ida Maria Josefine
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: disability, Sweden, neoliberalism, austerity, welfare, the welfare state, the state, welfare state, social democracy, bureaucratic violence.

description: Sweden has often been seen as the epitome of a social democratic welfare state. These accounts, however, often fail to take into consideration the development of neoliberal thought in Sweden and the expansion of austerity. Reflections regarding Sweden’s welfare state also often neglect to include disabled people. This is partly to do with the fact that the Swedish welfare state conflates illness and disability, which is rarely explored in Swedish disability research. This thesis will address these lacunas by investigating how disabled people in Sweden have been impacted by austerity. By looking at a range of areas, such as the social consequences of being a disabled person, bureaucracy, the representation of disabled people in economic theory, and employment, it offers a holistic approach to understand the development of Sweden into a neoliberal country and how disabled people have been affected by this change. The data for this thesis was gathered by interviewing 24 disabled people, eight welfare professionals, and eight disability organisation representatives. Using thematic data analysis, it became clear that disabled people experience stigma and discrimination in Sweden and that welfare bureaucracy has significant an impact on their lives. This was particularly the case for those whom cannot access resources on the ‘free market’. The thesis argues that the decreased provision of welfare resources for disabled people require a broader reflection upon the normative nature of economic theory and the social position of disabled people in Sweden.
Additional file 1: of Insulin-like growth factor-1-mediated regulation of miR-193a expression promotes the migration and proliferation of c-kit-positive mouse cardiac stem cells
Creators: name: Sun, Yuning
name: Xu, Rongfeng
name: Huang, Jia
name: Yao, Yuyu
name: Pan, Xiaodong
name: Chen, Zhongpu
name: Ma, Genshan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary data. (DOCX 1754 kb)
title: The effect of 'becoming' on trans* legal recognition
Creators: name: Rodgers, Amy
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Law, trans, transgender, gender recognition act, gender, sexuality, becoming, feminism, queer.

description: This thesis focuses on law’s conception of trans* embodiment and explores how the treatment of trans* lives by law exposes the existentially limiting understandings of ‘sex’ and ‘gender’ that underpin legal thinking. The thesis considers these limits on understanding to be problematic and limiting for the trans* community and uses theory to explore and advance a more appropriate and fluid scheme for legal recognition. Chapter one pays particular attention to the Gender Recognition Act 2004. It will be argued that it is based on the idea of the ‘authentic transsexual’ which, in the case of the Act, is founded on the separation of ‘sex’ and ‘gender’ and the construction of sex as dimorphic biological fact. Chapter two introduces and explores the idea of ‘becoming’ which can be used to re-figure what it means to be trans*. ‘Becoming’ can de-essentialise trans* lives in law and path the way for a more transformatory and fluid politics of recognition. Chapter three introduces a model of recognition that could be introduced in Scotland that is responsive to the self understood in terms of ‘becoming’. It will be argued that the model of self-identification and multiple gender scheme proposed balances trans* need for rights and protection with the demand that their sense of being and right to self-determination be protected. Finally, it is argued that this model is a necessary intermediate step in the move toward a post-gender world.
title: Game-theoretical approaches to social interaction
Creators: name: Nie, Li
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Game-theoretical approaches, social interaction, online interaction, social network, social media, monopolist's pricing, coordination, cultural learning.

description: This thesis consists of three chapters of economic analyses on social interaction, which mainly cover the topics of users’ online interaction and cross-cultural interaction in multicultural societies.
Post-selection Inference of High-dimensional Logistic Regression Under Case–Control Design
Creators: name: Lin, Yuanyuan
name: Xie, Jinhan
name: Han, Ruijian
name: Tang, Niansheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Confidence sets are of key importance in high-dimensional statistical inference. Under case–control study, a popular response-selective sampling design in medical study or econometrics, we consider the confidence intervals and statistical tests for single or low-dimensional parameters in high-dimensional logistic regression model. The asymptotic properties of the resulting estimators are established under mild conditions. We also study statistical tests for testing more general and complex hypotheses of the high-dimensional parameters. The general testing procedures are proved to be asymptotically exact and have satisfactory power. Numerical studies including extensive simulations and a real data example confirm that the proposed method performs well in practical settings.
Additional file 1: of Controlling Hypertension After Severe Cerebrovascular Event (CHASE): study protocol for a randomized controlled trial
Creators: name: Yuan, Fang
name: Yang, Fang
name: Xue, Changhu
name: Wang, Kangjun
name: Liu, Qiuwu
name: Zhou, Jun
name: Fu, Feng
name: Wang, Xiaocheng
name: Zhang, Wei
name: Liu, Yi
name: Huo, Kang
name: Lv, Hua
name: Jiang, Wen
Publisher: name: figshare
Year: 2018
Subjects: Developmental Biology
Marine Biology
Science Policy

description: SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (PDF 115 kb)
Jean-Philippe-Eugène-Antoine le Comte de la Chaussée
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: Officier de justice d'Ancien Régime

description: Source: http://www.sudoc.fr/080675700
description: Coverage: Parlement de Flandre
Post-selection inference of high-dimensional logistic regression under case-control design
Creators: name: Lin, Yuanyuan
name: Xie, Jinhan
name: Han, Ruijian
name: Tang, Niansheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Confidence sets are of key importance in high dimensional statistical inference. Under case-control study, a popular response-selective sampling design in medical study or econometrics, we consider the confidence intervals and statistical tests for single or low-dimensional parameters in high-dimensional logistic regression model. The asymptotic properties of the resulting estimators are established under mild conditions. We also study statistical tests for testing more general and complex hypotheses of the high-dimensional parameters. The general testing procedures are proved to be asymptotically exact and have satisfactory power. Numerical studies including extensive simulations and a real data example confirm that the proposed method performs well in practical settings.
A COMPARATIVE STUDY ON BIOCHEMICAL PROFILE AMONG PRE AND POST-SOFOSBUVIR-TREATED IN HCV PATIENTS, PAKISTAN
Creators: name: ISMAT ZHAIRA
name: Dr. HAMZA
name: SUMAIRA KAUSAR
name: ZOBIA MALIK
name: SAMRA RASHID
name: NUDRATULLAH SAAD
name: DUA ZHAIRA
Publisher: name: Zenodo
Year: 2024
Subjects: Thyroid Stimulating Hormone, Alanine Amino Transferase, Hepatitis C Virus.

description: Abstract

The viral infection known as hepatitis C (HCV) is a significant threat to health in Pakistan. Although powerful antiviral therapies are readily available, the disease load in the general population as a whole continues to rise. This may be because the infection is non-symptomatic, and delaying diagnosis until the disease has progressed significantly. Objectives: The study aims to contrast the biochemical profiles of patients with HCV before and after treatment with Sofosbuvir. Material and Methods: This was a cohort type of study with a sample size of 106. Patients with hepatitis C who went to the Medical Unit at the District Head Quarters Hospital in Rawalpindi between May 2019 and January 2020 were enrolled. To learn more about the patients' personal and medical histories, a questionnaire was created. Venipuncture was used to draw blood, and the Beckman Coulter AU480 chemistry analyzer was used to calculate serum uric acid levels, total cholesterol levels, triglycerides levels, ALT levels, and TSH levels. Performa was used to log data, which was then transferred to SPSS for analysis.  Results: In total 106 patients were studied, 75% were from Rawalpindi and 25% were from other areas of Pakistan. The mean age of patients enrolled in this study was 43.5 ± 12.3 years, 66.04% of the HCV patients have a negative family history, and the highest percentage (94.34%) of the patients are married. Patients were divided into two groups based on the duration of anti-HCV therapy Sofosbuvir as Pre- therapy and Post therapy.  The Pre and Post Sofosbuvir therapy found non-significant results of uric acid levels Mean ± S.D of (4.79 ± 1.57) v/s (5.22 ± 1.51) with p-value (>0.05), total cholesterol levels Mean ± S.D of (164.2 ± 37.22) v/s (174.1 ± 43.27) with p-value (>0.05), triglycerides levels Mean ± S.D of (136.7 ± 37.9) v/s (110 ± 20.3) with p-value (>0.05) and TSH levels Mean ± SD (2.10 ± 1.97) v/s (2.93 ± 1.82) with p-value (>0.05). But the significant result was found for ALT levels (90.3 ± 104.1) v/s (43.6 ± 33.8) with p-value (<0.05). Conclusion: This study's findings support the use of Sofosbuvir in the treatment of chronic HCV due to its low risk and impressive effectiveness. Related to decreased alanine transaminase (ALT) levels and the suppression of viral replication.
title: Making key pattern in Insular art: AD 600-1100
Creators: name: Thickpenny, Cynthia Rose
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: art history, archaeology, ornament, design, Insular art, early medieval art, pattern, Celtic Studies, Celtic Revival, key pattern, abstract art.

description: Key pattern is a type of abstract ornament characterised by spiral shapes which are angular rather than curved. It has been used to decorate objects and architecture around the world from prehistory onward, but flourished in a unique form in Insular art (the art of early medieval Britain and Ireland, c. AD 600-1100). Ornament of many kinds was the dominant mode in Insular art, however, key pattern has remained the least studied and most misunderstood. From the 19th century, specialists mainly have relied on simplified, line-drawn reproductions rather than original artworks. These ‘correct’ hand-made details, isolate patterns from their contexts, and in the case of Insular key pattern, de-emphasise its important physical structures. This resulted in misunderstandings of key pattern’s structure and an inability to recognise evidence for medieval artists’ working processes. Postwar art historians and archaeologists then largely abandoned study of ornament structure altogether, in critical reaction to this earlier method. For two centuries, academics have overlooked the artists’ role in pattern-making, and how their creative agency is reflected in patterns’ internal structures. In response, this thesis presents a new, artist-centred method for the study of Insular key pattern, which adapts Michael Brennan’s pioneering approach to Insular interlace (a different pattern), to suit key pattern’s distinct structure. Close examination of objects and monuments, rather than idealised ‘types’, has revealed how Insular artists themselves understood key pattern and handled it in the moment of creation. The core of the thesis is an analysis of key pattern’s structural properties, i.e. its physical parts and the abstract, often mathematical concepts that Insular makers used to arrange and manipulate these parts, in order to fix mistakes, fulfill specific design goals, or invent anew. Case studies of individual artworks support this analysis and demonstrate how key pattern is a vehicle for accessing Insular artists’ thought processes, as they improvised with the pattern’s basic structures for maximum creative effect. For the first time, this thesis also places Insular key pattern in its global context, via comparative analyses of key patterns from other world art traditions. This investigation has confirmed key pattern’s origin in prehistoric basketry and weaving technologies and explains why Insular key pattern’s geometric complexity remains unparalleled. The adaptation and expansion of this new analytical method for key pattern also proves its applicability to any type of ornament from any culture, making it immediately useful to art historians and archaeologists. This thesis therefore represents a larger paradigm shift that brings ornament study into the 21st century.
title: Making worlds with raven in rural Iceland: entangled memoir for the Anthropocene
Creators: name: Thomas, Sarah Elizabeth Annie
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Anthropocene, Iceland, Arctic, The North, creative non-fiction, memoir, The Raven's Nest, carrier bag theory of fiction, multi-species, entanglements, women's writing of The North, ethics of memoir.

description: The Anthropocene epoch calls for new narratives which accurately relate the experiences of our times from a diversity of perspectives. As humans make an irreversible impact on the geological record, I suggest that such narratives should engender more democratic and generative sharing of earth with other life forms – on the page as in life. Drawing upon my own transformative experiences of reciprocal living with human and non-human Others in the remote Westfjords of Iceland, I present a memoir, The Raven’s Nest, as my experiment towards such de-centred and ‘entangled’ writing (Haraway 2016). Covering the period of 2008 – 2014 it includes a variety of instabilities characteristic of the Anthropocene – economic, social, geological, and ecological – in the context of the everyday concerns of a sheep farming and fishing community at sixty-six degrees North. I argue that Anthropocenic narratives should resist a linear trajectory of beginning – middle – end, which is often wrongly conflated with the shape of ‘progress’, and instead find a new shape which can contain the ‘ongoingness’ of life, broken as it is. Drawing on Donna Haraway‘s concept of ‘entanglements’ (2016), and applying Ursula Le Guin’s ‘Carrier Bag Theory of Fiction’ (1989) to memoir, pulled together by Ingold’s ideas about ‘weaving’ as a way of being in the world (2000), I propose a woven, many threaded, container-shape composed of plant, animal and man-made materials: a ‘raven’s nest’. I highlight that the North as an idea – which includes Iceland – has been shaped by masculinist cultural representations which are a legacy of the era of polar exploration and remain dominant. This representation of North as an empty space; a wilderness; an extreme to be conquered or pentrated is in need of revision in our times. In search of an ‘ancestry’ that reflects my own experience of being a woman dwelling in the North and dependent on others for my survival, I find a number of women. From them, I focus on a canon of writers and a film-maker, identifying the tropes they share with my memoir and with each other which might be usefully incorporated into Anthropocenic narratives. Finally, I discuss the ethical implications of entanglement as it manifests in living, and in writing a memoir in the context of the academy. Acknowledging human ‘entanglements’ with other-than-human agents involves acknowledging the impact writing about them might have. This is true for places as much as for people. This thesis explores what happens when place speaks through human stories.
title: Fishery-induced evolution: understanding selection on physiology and behaviour using simulated fishery approaches
Creators: name: Thambithurai, Davide
Publisher: name: University of Glasgow
Year: 2019

description: Human predators are reshaping the evolutionary trajectories of wild animal populations. We are quickly changing the evolutionary landscape around us, through either active selection of desirable phenotypes, or by passive selection as a result of specific harvesting methods. Commercial fishing, with its global reach and enormous exploitation rates far in excess of natural predators, represents one of the strongest drivers of such anthropogenically-driven evolution. Our understanding of fisheries-induced evolution (FIE) is however fragmentary, historically reflecting a focus on size-selection and age at maturation. In addition, until now the vast majority of studies have investigated responses to selection on individual traits, as opposed to trying to understand the nexus of traits making up fishery vulnerability. In an effort to elucidate the evolutionary effect of commercial fishing on fish populations, and to understand some of the selective mechanisms that might operate in real fisheries, I conducted a number of laboratory simulations of commercial fishing on zebrafish Danio rerio. These experiments tested the importance of morphology, group behaviour and environmental stochasticity on fishery selection, as well as yielding an insight into the multigenerational effect of fishery selection.
title: Novel cyclopropane-based β-turn mimetics: evaluation within simple and complex peptide systems
Creators: name: Neckebroeck, Albane
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: peptides, synthesis, beta-turn, beta-hairpin, cyclopropane, TrpZip, Leu-enkephalin, peptidomimetic, turn mimic, NMR, CD, IR.

description: Peptides are crucial in biological processes: depending on their structure and location in the body they play different important roles. In vivo, peptides can be cleaved by proteases that degrade and reduce their activity. Studies have shown that peptide bonds can be mimicked in order to prevent cleavage in vivo while retaining bioactivity and increasing the solubility as well as the ability to control the folding of the peptide. Furthermore, synthetic targets that mimic conformational features of biologically active protein’ domains have raised an intense interest for organic and medicinal chemists. The target in peptidomimetics nowadays is to get a better biological activity than natural occurring peptides by mimicking their structure. This project focuses on the synthesis of peptidomimetics containing a cyclopropane as an amide bond isostere. Incorporation of a cyclopropane allows the molecule to be constrained conformationally, bringing hydrogen bond donor and acceptor groups together and facilitating reverse turn formation. To demonstrate this concept, the racemic and enantioenriched {GlyΔGly} dipeptide replacement units were synthesised and then incorporated at the centre of different short peptide chains. Optimisation and development of a new strategy is described in this thesis along with spectroscopic analyses to identify the secondary structure adopted by the peptides. IR, concentration-dependant NMR, 2D NOESY NMR and circular dichroism (CD) analyses were conducted to prove the formation of this secondary structure. The studies were performed on peptides with different lengths, in order to demonstrate the propensity of bêta-turn formation depending on number of residues (from two to five) but also depending on the solvent. Intramolecular hydrogen bond formation was determined by NMR and IR spectroscopy, which allowed identification of the conformation. 2D NMR and CD spectroscopy allowed to isolate precisely the conformation adopted by the mimics. Promising results from these model systems were obtained and applied to the synthesis of novel cyclopropane-based Leu-enkephalin and TrpZip peptide analogues. Those peptides are known to form bêta-turn and bêta-hairpin respectively, so controlling hydrogen bonding and the folding properties is particularly important. Herein is described the synthesis of the longer analogues using the Gly-Gly surrogate designed and their full conformational analysis. CD and 2D NMR conformational analysis were conducted in order to identify the folding pattern of the analogues designed.
title: Modulation of novel drug targets in neurotransmitter signalling to eradicate leukaemic stem cells in chronic myeloid leukaemia
Creators: name: Ritchie, Jake Thomas Shirley
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Chronic myeloid leukaemia, CML, leukaemic stem cell, novel therapy, dopamine.

description: The most significant obstacle in developing a cure for chronic myeloid leukaemia (CML) is the existence of TKI-insensitive leukaemic stem cells (LSCs) in patients with residual disease. Previous transcriptomics analysis pointed to neurotransmitter pathways as being active in LSC and normal haematopoietic stem cells (HSCs), but significantly deregulated between them. It was therefore hypothesised that these pathways may also have critical roles in LSC survival. To identify drug-able targets in these pathways, compound screens were performed in CML primary CD34+ cells and cell lines with 658 neurotransmitter-modulating compounds. These screens identified 120 significant hits and revealed that compounds targeting the dopaminergic signalling pathway were significantly over-represented (p<0.0001). A secondary screen of primary CML CD34+ versus non-CML CD34+ cells with these compounds, complemented with additional phenotypic assays (CFC and LTC-IC), revealed a number of compounds targeting the dopaminergic pathway with significant therapeutic windows. The D2-like dopamine receptor (DR) antagonist fluphenazine was identified as among those as having the greatest therapeutic potential. While fluphenazine had very little effect on the bulk CD34+ leukaemic cells, long term colony assays revealed that it selectively eradicates LSCs, reducing LTC-IC output to 5% compared to untreated control (p<0.001) whilst having very little effect on the LTC-IC output of HSCs. This is perhaps due to that fluphenazine +/- TKI inhibits a number of known LSC survival factors including PRKCH, FOXO3a and c-Myc in CML cell lines. Flow cytometry has revealed that LSCs express D2-like dopamine receptors at significantly higher levels compared to HSCs suggesting that fluphenazine’s mechanism of action in CML cells is likely through specific D2-like receptors. Furthermore, fluphenazine when combined with the TKI nilotinib is highly effective at eradicating LSCs compared to nilotinib alone in in vivo mouse models of CML. These results indicate that antagonising dopaminergic signalling could provide a novel mechanism to selectively eliminate the LSC population in CML whilst sparing HSCs.
Additional file 1: of Early-life exposure to PM2.5 and risk of acute asthma clinical encounters among children in Massachusetts: a case-crossover analysis
Creators: name: Khalili, Roxana
name: Bartell, Scott
name: Hu, Xuefei
name: Liu, Yang
name: Chang, Howard
name: Belanoff, Candice
name: Strickland, Matthew
name: Vieira, Verónica
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health
subject: Virology
subject: Computational Biology

description: Table S1. Selected demographic characteristics among children 5–9 years of age with asthma clinical encounters. Table S2. Odds ratios for a 5 μg/m3 increase in PM2.5 and asthma clinical encounters. Table S3. Odds ratios for a 5 μg/m3 increase in PM2.5 and asthma clinical encounters with stratified analysis. (DOCX 43 kb)
Comparison and optimization of CRISPR/dCas9/gRNA genome labeling systems for live cell imaging Additional file 1
Creators: name: Hong, Yu
name: Lu, Guangqing
name: Duan, Jinzhi
name: Liu, Wenjing
name: Zhang, Yu
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 310509
subject: Genomics

description: Comparison and optimization of CRISPR/dCas9/gRNA genome labeling systems for live cell imaging Additional file 1
title: Cardiovascular renal axis disorder and inflammatory response in feline congestive heart failure due to primary cardiomyopathy
Creators: name: Liu, Mengmeng
Publisher: name: University of Glasgow
Year: 2019

description: Congestive heart failure (CHF) is a common cardiac condition in cats, which usually results from primary cardiomyopathy (CM). It is a complex syndrome with many pathophysiological processes involved. The aim of this study was to investigate two aspects i.e. cardiovascular renal axis disorder (CvRD) and systemic inflammatory response in feline CHF due to primary CM. The study population included 25 CHF cats, 12 asymptomatic CM cats and 20 healthy control cats. Two panels of biomarkers were tested as reflections of CvRD (cardiac biomarker NTproBNP, renal biomarker SDMA and creatinine) and inflammatory response (7 acute phase proteins) respectively. The biomarker expressions in the three cat groups, correlations between the biomarkers and selected clinical variables, and risk factors in the CHF cats were analysed. Following the baseline studies, pilot longitudinal studies were carried out to investigate biomarker changes in 12 CHF cats over 12 months. The results showed both CvRD and systemic inflammatory response occurred in feline CHF. Considering the high prevalence of CvRD, it is recommended that the novel renal biomarker SDMA should be used as a renal function monitor in CHF management. Moreover, similar to NT-proBNP, it potentially carries prognostic value for feline CHF. Three acute phase proteins (APPs) showed significant changes in CHF (i.e. LRG1, ceruloplasmin and SAA) and may help to better understand the pathogenesis of feline CHF as well as predict the disease outcome. Positive correlations between APPs and cardiac variables suggested their intrinsic involvement in cardiac disease. In addition, serum AGP appeared to carry independent prognostic value for feline CHF. In combination with other clinical information, the APPs may be promising novel clinical biomarkers for feline CHF. Additionally, some clinical parameters were found to have the ability to stage CM and provide prognostic information. Preliminary results from longitudinal measurements showed that NT-proBNP measurements persistently higher than 1500 pmol/l, or a single SDMA measurement higher than 20 ug/dl appeared to be associated with a poorer outcome. Most APP expressions appeared to decrease over time. Future work will be needed to consolidate these findings. This study has identified novel CvRD and inflammatory biomarkers involved in a feline CHF study population. Current findings can be potentially implemented in future research and in clinical management of feline CHF and CM.
title: Beam-, target- and double-spin asymmetry measurements in deeply virtual π0, π+ and π- meson production
Creators: name: Murdoch, Gavin William
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Hadron physics, Deeply Virtual Meson Production, Generalised Parton Distributions, pion, nucleon, electroproduction, polarisation, spin asymmetry, JLab, EG1-DVCS.

description: This thesis presents measurements of spin asymmetries in single pion electroproduction from the EG1-DVCS experiment carried out at the Thomas Jefferson National Accelerator Facility in 2009 with use of the CEBAF Large Acceptance Spectrometer. The experiment made use of a 6 GeV longitudinally polarised electron beam and (dynamically) longitudinally polarised targets of 14NH3 and 14ND3 (giving access to protons and deuterons), providing the means to measure three spin asymmetries: beam-, target-, and double-spin. Deeply Virtual Meson Production for the π0, π+ and π- channels were studied for the kinematic range of Q^2 > 1 GeV^2 and W > 2 GeV. The collection of measurements includes the analysis of numerous reconstruction topologies, as well as making use of different target materials. These are the world’s first charged pion spin asymmetry measurements in this kinematic regime. The sPlot maximum likelihood fit-based background subtraction technique was implemented in the data analysis, showing strong agreement with a traditional and commonly used cuts-based approach. This novel technique was thoroughly tested to develop implementation and execution. The results obtained will provide a reference point for future analyses at the upgraded experimental facility and motivate the use of the sPlot technique. These measurements will provide insight into the structure of nucleons through their interpretation in relation to Generalised Parton Distributions which describe substructure correlations between longitudinal momentum and transverse position of partons. In particular, here the spin asymmetries dependence on t, the squared four-momentum transfer to the target nucleon, carries information on the spatial parton distributions in the transverse plane.
title: Transition trauma: a case-study of coping with becoming Neolithic
Creators: name: Telford, Denise Ann
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Neolithic, medical humanities, polished stone axe, Scotland, Trauma.

description: Change and transition are an inexorable and often emotionally painful part of being human. Despite this, British Neolithic grand narrative transitional models continue to focus upon ‘faceless’ top-down narratives of impersonal Neolithicisation (immigration vs indigenism). In contrast, this thesis explores a regional case-study of the human element of transition and its repercussions, so offering an alternative voice within Neolithic studies. In order to provide a reading of Early Neolithic society, a holistic line of investigation has been adopted. This encompasses several interdisciplinary methods and theoretical approaches including prehistoric archaeology, human geography, ethnography, and the Medical Humanities. The premise of this research is that becoming Neolithic was not a utopian outcome. Rather, Mesolithic-Neolithic social transformation has been defined as a period of ‘Transition Trauma’. Within this framework, the key aim of this thesis is to produce an emotional account of Neolithicisation by identifying human responses to an increasingly unstable world. More specifically, this research explores themes of nurture and ethical community care, as a way of coping with becoming Neolithic. In order to write an empathetic narrative of lived experience, the broken Group VI axehead assemblages of Early Neolithic Luce Sands (Dumfries and Galloway), their specialised chaîne opératoire, and their healing arctic/alpine source landscape in the Central Cumbrian Massif were chosen as case-studies. Group VI axe assemblages from Luce Sands are identified as the material culture of Neolithic Transition Trauma Response. Various connections are also drawn between these materials and the health giving properties of their high altitude source landscape across the Solway Firth. The analysis of the minutiae of these micronarratives allows for a bottom-up agent based reading of the psychological and physiological impact of Neolithic upheaval. New ideas and areas of research around the therapeutics of Neolithic axe polishing, plant pharmacology/medicinal geologies, and medical pilgrimage to healing landscapes are also suggested. Within this context, human behaviours of coping, the importance of shared ethics of care, and the advantages of female oriented responses to trauma are written. By re-centring people in this narrative, Neolithic care-giving responses are significant to the archaeology of emotion and to Neolithic discourse. Moreover, it is hoped that the potential therapeutic benefits of the ‘Transition Trauma Responses’ identified in this thesis might begin to contribute to cultural heritage therapy programmes for wellness in the future.
Additional file 1: of Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
Creators: name: Liu, Bowen
name: Wang, Tianjiao
name: Wang, Huawei
name: Zhang, Lu
name: Xu, Feifei
name: Fang, Runping
name: Li, Leilei
name: Cai, Xiaoli
name: Wu, Yue
name: Zhang, Weiying
name: Ye, Lihong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Table S1. List of primers and siRNA sequences used in this paper. (DOCX 22 kb)
Additional file 2: of Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
Creators: name: Liu, Bowen
name: Wang, Tianjiao
name: Wang, Huawei
name: Zhang, Lu
name: Xu, Feifei
name: Fang, Runping
name: Li, Leilei
name: Cai, Xiaoli
name: Wu, Yue
name: Zhang, Weiying
name: Ye, Lihong
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Cancer
subject: Plant Biology
subject: Virology

description: Table S2. Clinical characteristics of breast tissue microarray. (DOC 165 kb)
Additional file 3: of Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
Creators: name: Liu, Bowen
name: Wang, Tianjiao
name: Wang, Huawei
name: Zhang, Lu
name: Xu, Feifei
name: Fang, Runping
name: Li, Leilei
name: Cai, Xiaoli
name: Wu, Yue
name: Zhang, Weiying
name: Ye, Lihong
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Table S3. Clinical characteristics of 34 ER+ breast cancer tissue samples. (DOCX 19 kb)
Additional file 5: of Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
Creators: name: Liu, Bowen
name: Wang, Tianjiao
name: Wang, Huawei
name: Zhang, Lu
name: Xu, Feifei
name: Fang, Runping
name: Li, Leilei
name: Cai, Xiaoli
name: Wu, Yue
name: Zhang, Weiying
name: Ye, Lihong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional methods. (DOCX 27 kb)
title: R. B. Cunninghame Graham’s contribution to the political and literary life of Scotland: party, prose, and the political aesthetic
Creators: name: Munro, Lachlan Gow
Publisher: name: University of Glasgow
Year: 2019

description: This thesis examines the substantive and verifiable political and cultural legacy of the social reformer and author, Robert Bontine Cunninghame Graham (1852-1936), one of the most famous and controversial Scots of his generation. Much has been written about Graham before and after his death, in biographies, memoirs, and analyses of his large canon of essays, but there has been little analysis of his political beliefs and the influences that shaped them, and how these directed his efforts into the creation of the first party of labour in Britain, and his later involvement in the first nationalist party in Scotland. The thesis therefore seeks to uncover Graham’s philosophies through his political statements, and to extrapolate them, where possible, into the themes of his political campaigns and in his later literary works. It is thus the intention to transcend previous perspectives by looking at Graham not solely as a politician, nor an author, but as an eloquent, disquieted, principled, fervid moralist and contrarian, for whom politics and writing were fundamentally the same thing, the means by which his deeply felt moral anger could be expressed.
title: Dressing Eve and other reparative acts in women’s autobiographical comics
Creators: name: Lightman, Sarah
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: graphic novel, comics, autobiography, Jewish studies, feminism, memoir, feminist theology.

description: “Dressing Eve and Other Reparative Acts in Women’s Autobiographical Comics” asks why Jewish and Christian women comics artists incorporate biblical narratives and images in their autobiographical works. How do these comics artists highlight and challenge androcentric biblical references, narratives and images, and can these comics be considered feminist reparative acts, as they critique patriarchal religion? My hypothesis is that Sharon Rudahl’s four-page comic “The Star Sapphire”, Miriam Katin’s graphic novel We Are On Our Own, Bobby Baker’s diary drawings and pre-diary drawings, and my own graphic novel The Book of Sarah participate in the process of transforming biblical narratives and images into feminist responses. These artists highlight the androcentric ideology at work in biblical texts, and challenge the representation of the female body and women’s roles within the narratives. J. Cheryl Exum asks in Plotted, Shot, and Painted: Cultural Representations of Biblical Women, “Can women ever win, either in the biblical text or in its literary, musical or artistic afterlife?” (2012:14). Rudahl dresses Eve, Baker undresses the Virgin Mary, Katin distresses Queen Esther and I re-address the Matriarch Sarah to ensure that women in the Bible do, indeed, win in their biblical visual/verbal afterlives. “Dressing Eve” is an extension of the feminist project that celebrates the personal within the academic, and I adopt a direct and personal tone of writing as well as focus in my fourth chapter on my own graphic novel in progress. The methodology for my thesis is innovative as I frequently apply fine art examples and feminist art historical analysis in my study of autobiographical comics. I have coined the phrase “art-com-text” to describe my unique theoretical methodology: constructing relationships between significant images within comics in a wider visual cultural context, and making associations with other salient and relevant examples in fine art history. I also interviewed Rudahl, Katin and Baker, as well as other women artists and comics artists: Helène Aylon, Aline Kominsky-Crumb, Julie Held and Joanne Leonard.
title: Molecular probes for understanding disease using PET and fluorescence imaging
Creators: name: Morgan, Timaeus Edmund Francis
Publisher: name: University of Glasgow
Year: 2019
Subjects: subject: Organic chemistry, radiochemistry, positron emission tomography.

description: During the course of this PhD, several libraries of potential PET imaging agents were synthesised for testing their affinity and selectivity for sphingosine-1-phosphate 5 receptors (S1P5). These receptors are located within oligodendrocytes and are proposed to have a major role in the re-myelination of neurons. Imaging of these receptors could lead to new treatments and diagnostic tools for the management of demyelinating disorders, such as multiple sclerosis (MS). The libraries of compounds were subject to biological evaluation and two lead compounds, fluorobenzamides 89 and 94, were identified as being the most potent and selective for S1P5 receptors. The synthesis of a further compound that was described in the literature as having high affinity for S1P5 was adapted to allow for the preparation of precursor 124 for 11C-labelling. The radiosynthesis of compound [11C]33 was then optimised. An improved synthesis of AB5186, an imaging agent for the translocator protein (TSPO),was developed. TSPO has been shown to be involved in inflammatory processes and is a biomarker for many inflammatory diseases. Evaluation of AB5186 led to the synthesis of a higher affinity compound LW223 (155), which was not sensitive to the single nucleotide polymorphism present in TSPO. A synthesis of LW223 (155) was developed that allowed for the production of two potential precursors for radiofluorination. Investigation of the radiochemistry showed a chloro-precursor was the most efficient for 18F-labelling. Finally, an investigation into a polymer-supported nitrite reagent approach for the synthesis of benzotriazole derived α-amino acids allowed the preparation of a variety of functionalised compounds in relatively few steps. Further derivatisation of these compounds led to the discovery of a benzotriazole derived α-amino acid 212 with strong fluorescence in the visible region.
Duration of labor and severe PPH
Creators: name: Nyfløt, Lill
Publisher: name: figshare
Year: 2017
Subjects: subject: 111402 Obstetrics and Gynaecology
subject: FOS: Clinical medicine

description: Dataset from a case-control study on the association between duration of active labor and severe postpartum hemorrhage. Tha data was analyzed i STATA. The data collection was approved by the Regional Ethics Comittee in the South-East Health Region of Norway.
Additional file 1: of Quantitative cardiovascular magnetic resonance perfusion imaging identifies reduced flow reserve in microvascular coronary artery disease
Creators: name: Zorach, Benjamin
name: Shaw, Peter
name: Bourque, Jamieson
name: Kuruvilla, Sujith
name: Balfour, Pelbreton
name: Yang, Yang
name: Mathew, Roshin
name: Pan, Jonathan
name: Gonzalez, Jorge
name: Taylor, Angela
name: Meyer, Craig
name: Epstein, Frederick
name: Kramer, Christopher
name: Salerno, Michael
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified

description: Quantitative CMR perfusion imaging identifies reduced flow reserve in microvascular CAD. (DOCX 19Â kb)
MOESM1 of Directly mining a fungal thermostable Îą-amylase from Chinese Nong-flavor liquor starter
Creators: name: Yi, Zhuolin
name: Fang, Yang
name: He, Kaize
name: Liu, Dayu
name: Luo, Huibo
name: Zhao, Dong
name: He, Hui
name: Jin, Yanling
name: Zhao, Hai
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1. Additional tables.
Additional file 1: of Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer
Creators: name: Liu, Mingshan
name: Liu, Yang
name: Deng, Lu
name: Wang, Dong
name: He, Xueyan
name: Zhou, Lei
name: Wicha, Max
name: Bai, Fan
name: Liu, Suling
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary informationÂ including Materials and Methods, Figure S1-5Â and Table S1 S5. (DOCX 1332 kb)
title: 02_0234
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/