cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Saturn's fast spin determined from its gravitational field and oblateness
Creators: name: Helled, Ravit
name: Galanti, Eli
name: Kaspi, Yohai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The alignment of Saturn's magnetic pole with its rotation axis precludes the use of magnetic field measurements to determine its rotation period. The period was previously determined from radio measurements by the Voyager spacecraft to be 10h 39m 22.4s. When the Cassini spacecraft measured a period of 10h 47m 6s, which was additionally found to change between sequential measurements, it became clear that the radio period could not be used to determine the bulk planetary rotation period. Estimates based upon Saturn's measured wind fields have increased the uncertainty even more, giving numbers smaller than the Voyager rotation period, and at present Saturn's rotation period is thought to be between 10h 32m and 10h 47m, which is unsatisfactory for such a fundamental property. Here we report a period of 10h 32m 45s +- 46s, based upon an optimization approach using Saturn's measured gravitational field and limits on the observed shape and possible internal density profiles. Moreover, even when solely using the constraints from its gravitational field, the rotation period can be inferred with a precision of several minutes. To validate our method, we applied the same procedure to Jupiter and correctly recovered its well-known rotation period.
description: Accepted for publication in Nature, published online on March 25, 2015 Includes methods and supplementary figures
title: Axillary assesment in breast cancer: imaging features to improve detection of metastasis
Creators: name: Aggarwal, Reena
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Lymph nodes
subject: Ultrasound
subject: Staging
subject: Surgery
subject: Metastases
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The purpose of this study was: To determine the sensitivity/specificity for detecting axillary node metastases ( Fig. 1 ) on pre-operative ultrasound according to cortical thickness. To explore why some histologically confirmed metastatic lymph...
Understanding the Detection of View Fraud in Video Content Portals
Creators: name: Marciel, Miriam
name: Cuevas, Ruben
name: Banchs, Albert
name: Gonzalez, Roberto
name: Traverso, Stefano
name: Ahmed, Mohamed
name: Azcorra, Arturo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: While substantial effort has been devoted to understand fraudulent activity in traditional online advertising (search and banner), more recent forms such as video ads have received little attention. The understanding and identification of fraudulent activity (i.e., fake views) in video ads for advertisers, is complicated as they rely exclusively on the detection mechanisms deployed by video hosting portals. In this context, the development of independent tools able to monitor and audit the fidelity of these systems are missing today and needed by both industry and regulators. In this paper we present a first set of tools to serve this purpose. Using our tools, we evaluate the performance of the audit systems of five major online video portals. Our results reveal that YouTube's detection system significantly outperforms all the others. Despite this, a systematic evaluation indicates that it may still be susceptible to simple attacks. Furthermore, we find that YouTube penalizes its videos' public and monetized view counters differently, the former being more aggressive. This means that views identified as fake and discounted from the public view counter are still monetized. We speculate that even though YouTube's policy puts in lots of effort to compensate users after an attack is discovered, this practice places the burden of the risk on the advertisers, who pay to get their ads displayed.
description: To appear in WWW 2016, Montr\'eal, Qu\'ebec, Canada. Please cite the conference version of this paper
title: Acupoint-specific effect of acupuncture in Alzheimer's disease: a functional MRI study
Creators: name: Shan, Yi
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: CNS
subject: MR-Functional imaging
subject: Neural networks
subject: Treatment effects
subject: Efficacy studies
subject: Dementia

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Acupuncture remains promising as an investigational therapy to treat neurological diseases including dementia. Recently, clarifying the intrinsic mechanisms of its clinical effects has become increasingly popular research. Alzheimer’s disease (AD)...
Social support and response to AIDS and severe acute respiratory syndrome
Creators: name: Aiello, A.
name: Galea, S.
name: Des Jarlais, D.C.
name: Tracy, M.
name: Nandi, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Negative public reactions to emerging infectious diseases can adversely affect population health. We assessed whether social support was associated with knowledge of, worry about, and attitudes towards AIDS and severe acute respiratory syndrome. Our findings suggest that social support may be central to our understanding of public responses to emerging infectious diseases.
Predictions Based on the Clustering of Heterogeneous Functions via Shape and Subject-Specific Covariates
Creators: name: Page, Garritt L.
name: Quintana, Fernando A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We consider a study of players employed by teams who are members of the National Basketball Association where units of observation are functional curves that are realizations of production measurements taken through the course of one's career. The observed functional output displays large amounts of between player heterogeneity in the sense that some individuals produce curves that are fairly smooth while others are (much) more erratic. We argue that this variability in curve shape is a feature that can be exploited to guide decision making, learn about processes under study and improve prediction. In this paper we develop a methodology that takes advantage of this feature when clustering functional curves. Individual curves are flexibly modeled using Bayesian penalized B-splines while a hierarchical structure allows the clustering to be guided by the smoothness of individual curves. In a sense, the hierarchical structure balances the desire to fit individual curves well while still producing meaningful clusters that are used to guide prediction. We seamlessly incorporate available covariate information to guide the clustering of curves non-parametrically through the use of a product partition model prior for a random partition of individuals. Clustering based on curve smoothness and subject-specific covariate information is particularly important in carrying out the two types of predictions that are of interest, those that complete a partially observed curve from an active player, and those that predict the entire career curve for a player yet to play in the National Basketball Association.
description: Published at http://dx.doi.org/10.1214/14-BA919 in the Bayesian Analysis (http://projecteuclid.org/euclid.ba) by the International Society of Bayesian Analysis (http://bayesian.org/)
(103395) Cuthbert Baring Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Adenosine and adenosine triphosphate (ATP) have a similar stress effect in patients undergoing stress/rest perfusion cardiac magnetic resonance examinations
Creators: name: Bartolomé, Pablo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: MR
subject: Diagnostic procedure
subject: Drugs / Reactions

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Most recent guidelines on myocardial revascularization recommend documentation of ischemia using functional non-invasive testing before elective invasive procedures in patients with suspected stable coronary artery disease. Vasodilator-induced...
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms
Creators: name: Kang, H.J.
name: Cherezov, V.
name: Savych, O.
name: Kenakin, T.
name: Shoichet, B.K.
name: Glatfelter, G.C.
name: Huang, X.-P.
name: Roth, B.L.
name: Johansson, L.C.
name: Stauch, B.
name: Slocum, S.
name: Dubocovich, M.L.
name: Moroz, Y.S.
name: Che, T.
name: Irwin, J.J.
name: Stein, R.M.
name: McCorvy, J.D.
name: Jones, A.J.
Publisher: name: Nature Research
Year: 2020

description: The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus, synchronizing the physiology and behaviour of animals to the light–dark cycle1–4. The two receptors are established drug targets for aligning circadian phase to this cycle in disorders of sleep5,6 and depression1–4,7–9. Despite their importance, few in vivo active MT1-selective ligands have been reported2,8,10–12, hampering both the understanding of circadian biology and the development of targeted therapeutics. Here we docked more than 150 million virtual molecules to an MT1 crystal structure, prioritizing structural fit and chemical novelty. Of these compounds, 38 high-ranking molecules were synthesized and tested, revealing ligands with potencies ranging from 470 picomolar to 6 micromolar. Structure-based optimization led to two selective MT1 inverse agonists—which were topologically unrelated to previously explored chemotypes—that acted as inverse agonists in a mouse model of circadian re-entrainment. Notably, we found that these MT1-selective inverse agonists advanced the phase of the mouse circadian clock by 1.3–1.5 h when given at subjective dusk, an agonist-like effect that was eliminated in MT1- but not in MT2-knockout mice. This study illustrates the opportunities for modulating melatonin receptor biology through MT1-selective ligands and for the discovery of previously undescribed, in vivo active chemotypes from structure-based screens of diverse, ultralarge libraries. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.
Finite-temperature quantum criticality in a complex-parameter plane
Creators: name: Li, Ci.
name: Song, Zhi.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A conventional quantum phase transition (QPT) occurs not only at zero temperature, but also exhibits finite-temperature quantum criticality. Motivated by the discovery of the pseudo-Hermiticity of non-Hermitian systems, we explore the finite-temperature quantum criticality in a non-Hermitian PT -symmetric Ising model. We present the complete set of exact eigenstates of the non-Hermitian Hamiltonian, based on which the mixed-state fidelity in the context of biorthogonal bases is calculated. Analytical and numerical results show that the fidelity approach to finite-temperature QPT can be extended to the non-Hermitian Ising model. This paves the way for experimental detection of quantum criticality in a complex-parameter plane.
description: 6 pages, 10 figures
Research Matters: How many people are LGBTIQ?
Creators: name: Carman, Marina
name: Farrugia, Claire
name: Bourne, Adam
name: Power, Jennifer
name: Rosenberg, Shoshana
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420305
subject: Health and community services

description: Accurately estimating the number of people who are lesbian, gay, bisexual, trans and gender diverse and intersex (LGBTIQ*) in Australia is a critical gap in research. The lack of current population-level data limits understanding of health and wellbeing needs of LGBTIQ people, and the development of policy and programs for LGBTIQ communities.
 A fact sheet by Rainbow Health Victoria.
 © La Trobe University 2020
title: Role of T1 mapping on the evaluation of cardiac perfusion during adenosine stress CMR in CAD patients
Creators: name: cannizzaro, ester
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Cardiac
subject: MR
subject: Diagnostic procedure

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Atherosclerosis is a systemic disease process characterized by the accumulation of lipids and fibrous elements often associated with inflammation in arterial walls, and underlying cause of the majority of clinical cardiovascular events 1 . Coronary...
Exotic Nuclei and Matter in a Chirally Effective Approach
Creators: name: Schramm, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A relativistic approach to describe nuclear and in general strongly interacting matter is introduced and discussed. Here, not only the nuclear forces but also the masses of the nucleons are generated through meson fields. Within this framework it is possible to calculate properties of finite nuclei at a level of accuracy similar to dedicated relativistic nuclear structure models. Due to the more general approach, a wider range of properties of hadronic states can be investigated. A number of results for heavy and neutron-rich nuclei toward the drip line are presented.
description: Contribution to the Proceedings of the VII International Symposium on EXOtic Nuclei (EXON-2014) in St. Petersburg, Russia
title: Quantitative assessment of salvaged myocardial zone and intramyocardial haemorrhage by 7T MRI
Creators: name: zhang, yan
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: Contrast agents
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Functional imaging
subject: Biopsy
subject: Dilation
subject: Safety
subject: Acute
subject: Outcomes
subject: Blood

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To determine the myocardial area at risk (AAR), infarction-core size (IS) and the salvaged myocardial zone (SMZ), and to evaluate the imaging and histological characteristics of intramyocardial hemorrhage (IMH) after myocardial infarction using...
Derivation of the linear Landau equation and linear Boltzmann equation from the Lorentz model with magnetic field
Creators: name: Marcozzi, Matteo
name: Nota, Alessia
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider a test particle moving in a random distribution of obstacles in the plane, under the action of a uniform magnetic field, orthogonal to the plane. We show that, in a weak coupling limit, the particle distribution behaves according to the linear Landau equation with a magnetic transport term. Moreover, we show that, in a low density regime, when each obstacle generates an inverse power law potential, the particle distribution behaves according to the linear Boltzmann equation with a magnetic transport term. We provide an explicit control of the error in the kinetic limit by estimating the contributions of the configurations which prevent the Markovianity. We compare these results with those ones obtained for a system of hard disks in \cite{BMHH}, which show instead that the memory effects are not negligible in the Boltzmann-Grad limit.
description: 22 pages, 4 figures in Journal of Statistical Physics 2016
(103396) Hilda Agnes Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Structural Understanding of Class B GPCR Selectivity and Activation Revealed
Creators: name: Krumm, B.
name:  Roth, B.L.
Publisher: name: Cell Press
Year: 2020

description: Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs. Ma et al. (2020) and Liang et al. (2020) describe the cryo-EM structures of three class B G protein-coupled receptors (GPCRs) in complex with native peptides and Gs. Their work establishes the structural basis of peptide specificity and a conserved mechanism of receptor activation and G protein coupling for class B GPCRs.
Nonlinear vortex dichroism in chiral molecules
Creators: name: Cheeseman, Luke
name: Forbes, Kayn A
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optics (physics.optics)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The recent discovery that linearly polarized light with a helical wavefront can exhibit vortex dichroism (also referred to as helical dichroism) has opened up new horizons in chiroptical spectroscopy with structured chiral light. Recent experiments have now pushed optical activity with vortex beams into the regime of nonlinear optics. Here we present the theory of two-photon absorption (TPA) of focused optical vortices by chiral molecules: nonlinear vortex dichroism (NVD). We discover that highly distinct features arise in the case of TPA with focused vortex beams, including the ability to probe chiral molecular structure not accessible to current methods and that the differential rate of TPA is significantly influenced by the orientation of the state of linear polarization. This work provides strong evidence that combining nonlinear optical activity with structured light provides new and improved routes to studying molecular chirality.
title: How to assess haemodynamic aspect of not-evaluable plaques by cardiac CT? Use of CCO and role of stress CMR
Creators: name: Palumbo, Pierpaolo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: CT
subject: MR
subject: Contrast agent-intravenous
subject: Diagnostic procedure

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Some study have demonstred how CCO changes across coronary stenoses are predictive of abnormal resting coronary blood flow 1 and how its use can help in detection of in-stent restenosis 2 . In particular, CCO is much useful in quantification of...
Heat as a witness of quantum properties
Creators: name: Junior, A. de Oliveira
name: Brask, Jonatan Bohr
name: Lipka-Bartosik, Patryk
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a new approach for witnessing quantum resources, such as entanglement and coherence, based on heat generation. Inspired by Maxwell's demon, we ask what the optimal heat exchange between a quantum system and a thermal environment is when the process is assisted by a quantum memory. We derive fundamental energy constraints in this scenario and show that quantum states can reveal non-classical signatures via heat exchange. This approach leads to a heat-based witness for quantum properties, offering an alternative to system-specific measurements, as it only relies on fixed energy measurements in a thermal ancilla. We illustrate our findings with the detection of entanglement in isotropic states and coherence in two-spin systems interacting with a single-mode electromagnetic field.
description: 11 pages, 4 figures. Published version
Explanation of a special color-magnitude diagram of star cluster NGC 1651 from different models
Creators: name: Li, Zhongmu
name: Mao, Caiyan
name: Chen, Li
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The color-magnitude diagram (CMD) of globular cluster NGC1651 has special structures including a broad main sequence, an extended main sequence turn-off and an extended red giant clump. The reason for such special CMDs remains unclear. In order to test how different the results from various stellar population assumptions are, we study a high-quality CMD of NGC1651 from the Hubble Space Telescope archive via eight kinds of models. Distance modulus, extinction, age ranges, star formation mode, fraction of binaries, and fraction of rotational stars are determined and then compared. The results show that stellar populations both with and without age spread can reproduce the special structure of the observed CMD. A composite population with extended star formation from 1.8\,Gyrs ago to 1.4\,Gyrs ago, which contains 50 per cent binaries and 70 per cent rotational stars, fits the observed CMD best. Meanwhile, a 1.5\,Gyr-old simple population that consists of rotational stars can also fit the observed CMD well. The results of CMD fitting are shown to depend strongly on stellar population type (simple or composite), and fraction of rotators. If the member stars of NGC1651 formed in a single star burst, the effect of stellar rotation should be very important for the explanation of observed CMDs. Otherwise, the effect may be small. It is also possible that the special observed CMD is a result of the combined effects of stellar binarity, rotation and age spread. Therefore, further work on stellar population type and fraction of rotational stars of intermediate-age clusters are necessary to understand their observed CMDs.
description: Published in ApJ
Bayesian binomial mixture models for estimating abundance in ecological monitoring studies
Creators: name: Wu, Guohui
name: Holan, Scott H.
name: Nilon, Charles H.
name: Wikle, Christopher K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Investigation of species abundance has become a vital component of many ecological monitoring studies. The primary objective of these studies is to understand how specific species are distributed across the study domain, as well as quantification of the sampling efficiency for detecting these species. To achieve these goals, preselected locations are sampled during scheduled visits, in which the number of species observed at each location is recorded. This results in spatially referenced replicated count data that are often unbalanced in structure and exhibit overdispersion. Motivated by the Baltimore Ecosystem Study, we propose Bayesian hierarchical binomial mixture models, including Binomial Conway-Maxwell Poisson (Bin-CMP) mixture models, that formally account for varying levels of spatial dispersion. Our proposed models also allow for variable selection of model covariates and grouping of dispersion parameters through the implementation of reversible jump Markov chain Monte Carlo methodology. Finally, using demographic covariates from the American Community Survey, we demonstrate the effectiveness of our approach through estimation of abundance for the American Robin (Turdus migratorius) in the Baltimore Ecosystem Study.
description: Published at http://dx.doi.org/10.1214/14-AOAS801 in the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
On Lovelock galileons and black holes
Creators: name: Charmousis, Christos
name: Tsoukalas, Minas
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study a scalar-tensor version of Lovelock theory with a non trivial higher order galileon term involving the coupling of the Lovelock two tensor with derivatives of the scalar galileon field. For a static and spherically symmetric spacetime we extend the Boulware-Deser solution to the presence of a Galileon field. The hairy solution has a regular scalar field on the black hole event horizon and presents certain self tuning properties for the bulk cosmological constant and the Gauss-Bonnet coupling. The combined time and radial dependence of the galileon field permits its horizon regularity. Furthermore in order to investigate the effects of linear time dependence we find spherically symmetric solutions in 4 and 5 spacetime dimensions. They are shown to have singular horizons. Afar from the Schwarzschild radius and for weak higher dimensional couplings the solutions are perturbratively close to GR representing GR like star solutions for scalar tensor theories.
description: 11 pages, minor corrections, references added, version accepted to PRD
title: Fragile Vaterschaft
title: Familienkonzepte zwischen Wandel und Beharrlichkeit
titleType: Subtitle
Creators: name: Fankhauser, Lilian
Publisher: name: Humboldt-Universität zu Berlin
Year: 2007
Subjects: subject: Familie
subject: Beruf
subject: Geschlechterrolle
subject: Arbeit
subject: Gleichstellungspolitik
subject: Vereinbarkeit
subject: Väter
subject: 300 Sozialwissenschaften

description: Öffentliche Debatten um Vereinbarkeit von Familie und Beruf drehen sich häufig um das Verhältnis von Mutter und Kind und um die Frage, wie sich mütterliche Erwerbstätigkeit auf die Kinder auswirke. Dieser einseitige Blick auf die Mütter verdeckt, welch zentrale Rolle Väter im Spannungsfeld von Persistenz und Wandel familialer Konzepte spielen.
title: Evaluating a new objective indicator of idiopathic intracranial hypertension (IIH) on routine paediatric brain CT scan
Creators: name: Bartsikhovsky, Tetiana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Paediatric
subject: Neuroradiology brain
subject: CT
subject: Diagnostic procedure
subject: Cerebrospinal fluid

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Idiopathic intracranial hypertension (IIH) is defined as elevated intracranial pressure (ICP) without evidence of a secondary cause and is well recognized in pediatric population. Both brain CT scan and ophthalmologic examination are part of...
(103392) Edith Harriet Josephine Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nanobody-enabled monitoring of kappa opioid receptor states
Creators: name:  Sciaky, N.
name:  Diberto, J.F.
name:  Steyaert, J.
name:  Carroll, F.I.
name:  Roth, B.L.
name:  Zhang, S.
name:  Pardon, E.
name:  English, J.
name:  Wang, S.
name:  Krumm, B.E.
name:  Kim, K.
name:  Olsen, R.H.J.
name: Che, T.
name:  Wacker, D.
Publisher: name: Nature Research
Year: 2020

description: Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a relative lack of suitable tools. We previously reported two nanobodies (Nb39 and Nb6) that stabilize distinct ligand- and efficacy-delimited conformations of the kappa opioid receptor. Here, we demonstrate via X-ray crystallography a nanobody-targeted allosteric binding site by which Nb6 stabilizes a ligand-dependent inactive state. As Nb39 stabilizes an active-like state, we show how these two state-dependent nanobodies can provide real-time reporting of ligand stabilized states in cells in situ. Significantly, we demonstrate that chimeric GPCRs can be created with engineered nanobody binding sites to report ligand-stabilized states. Our results provide both insights regarding potential mechanisms for allosterically modulating KOR with nanobodies and a tool for reporting the real-time, in situ dynamic range of GPCR activity.
title: Comparison of aortic root dimensions by multimodal measurement before transcatheter aortic valve implantation
Creators: name: Qi, Ruixiang
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: CT
subject: Echocardiography
subject: Echocardiography (transoesophageal)
subject: Catheters

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: We sought to compare 3 methods of measurements of the aortic root in patients of severe aortic stenosis (AS), transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and multislice computed tomography (MSCT), and to evaluate...
(103394) Winifred Zoe Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Optimal Frames for Polarisation State Reconstruction
Creators: name: Foreman, Matthew R.
name: Favaro, Alberto
name: Aiello, Andrea
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Complete determination of the polarisation state of light requires at least four distinct projective measurements of the associated Stokes vector. Stability of state reconstruction, however, hinges on the condition number $κ$ of the corresponding instrument matrix. Optimisation of redundant measurement frames with an arbitrary number of analysis states, $m$, is considered in this Letter in the sense of minimisation of $κ$. The minimum achievable $κ$ is analytically found and shown to be independent of $m$, except for $m=5$ where this minimum is unachievable. Distribution of the optimal analysis states over the Poincaré sphere is found to be described by spherical 2-designs, including the Platonic solids as special cases. Higher order polarisation properties also play a key role in nonlinear, stochastic and quantum processes. Optimal measurement schemes for nonlinear measurands of degree $t$ are hence also considered and found to correspond to spherical $2t$-designs, thereby constituting a generalisation of the concept of mutually unbiased bases.
title: Diagnostic accuracy of coronary CT angiography performed in 100 consecutive patients with coronary stents using a novel whole organ high-definition CT scanner
Creators: name: Andreini, Daniele
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Cardiac
subject: CT
subject: CT-Angiography
subject: CT-High Resolution
subject: CAD
subject: Arteriosclerosis
subject: Artifacts

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Coronary CT angiography (CCTA) has emerged as a reliable tool for the diagnosis of coronary artery disease and for the evaluation of patients after previous coronary artery intervention (PCI). However, visualization of stented segment lumen and...
Analyse der Wartezeiten in der Psychotherapie in Bayern
Creators: name: Ritter-Rupp, Claudia
name: Fett, Sandra
name: Pfeifer, Anne-Kathrin
name: Tauscher, Martin
Publisher: name: Zenodo
Year: 2023
Subjects: Psychotherapie
Wartezeiten
ambulante Versorgung
Versorgungsforschung
Bayern

description: Veröffentlichungen zu Wartezeiten für Patienten mit psychischen Erkrankungen auf den Beginn einer psychotherapeutischen Behandlung basieren auf verschiedenen Datenquellen (Befragungen von Patienten, Befragungen von Psychotherapeuten, Abrechnungsdaten einzelner Krankenkassen oder einer Stichprobe von Therapeuten u.a.) und kommen zu unterschiedlichen Ergebnissen. Die vorliegende Studie geht der Frage nach, welchen Umfang der Zeitraum zwischen der ersten dokumentierten psychotherapeutischen Sprechstunde und dem ersten dokumentierten Psychotherapie-Kontakt hat. Analysis of Waiting Times for Psychotherapy in Bavaria, Germany Publications investigating waiting times for psychotherapy have used a variety of data sources (patient surveys, surveys of psychotherapists, claims data from individual health insurance funds, or samples of psychotherapists). As a result, they have arrived at different conclusions. The present study uses claims data from the German federal state of Bavaria to estimate the time between the initial contact at a psychotherapist and the start of a treatment programme. The median waiting time is found to be 97 days, with considerable variation between age groups and regions.
title: Monochromatic imaging improving accuracy of coronary stenosis with heavy calcification compared with conventional imaging and invasive coronary angiography
Creators: name: Yi, Yan
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: Vascular
subject: CT
subject: CT-Angiography
subject: Image manipulation / Reconstruction
subject: Technology assessment

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To investigate the performance of monochromatic imaging[1-3] in assessing the stenosis with heavy calcification[4-5] by coronary CT angiography (CCTA)[6-7], compared with conventional 120 kVp image[8] and invasive coronary angiography (ICA) as...
Net on-chip Brillouin gain based on suspended silicon nanowires
Creators: name: Van Laer, Raphaël
name: Bazin, Alexandre
name: Kuyken, Bart
name: Baets, Roel
name: Van Thourhout, Dries
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The century-old study of photon-phonon coupling has seen a remarkable revival in the past decade. Driven by early observations of dynamical back-action, the field progressed to ground-state cooling and the counting of individual phonons. A recent branch investigates the potential of traveling-wave, optically broadband photon-phonon interaction in silicon circuits. Here, we report continuous-wave Brillouin gain exceeding the optical losses in a series of suspended silicon beams, a step towards selective on-chip amplifiers. We obtain efficiencies up to $10^{4} \, \text{W}^{-1}\text{m}^{-1}$, the highest to date in the phononic gigahertz range. We also find indications that geometric disorder poses a significant challenge towards nanoscale phonon-based technologies.
description: 14 pages, 8 figures
title: Comparison between the conventional Couinaud method vs a semiautomatic software (Syngo.CT. liver analysis, Siemens) in the precise localisation of liver metastases
Creators: name: Bartolomé, Pablo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Anatomy
subject: Computer applications
subject: CT
subject: Computer Applications-General
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Hepatic segmentation is usually performed following Couinaud's system whichdivides the liver into8 functionally independenthepatic segments. In the centre of each segment there is a branch of the portal vein, hepatic artery and bile duct. It uses...
title: Comprehensiveness of EHSRGE/ESGE classification of female genital tract anomalies: systematic review of cases by MRI
Creators: name: Yadav, Pratiksha
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genital / Reproductive system female
subject: MR
subject: Comparative studies
subject: Education
subject: Congenital
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Abstract: Uterine congenital anomalies are clinically relevant because these are associated with increased incidences of infertility and menstrual disorder Most widely used classification system by American fertility society made in 1988.It is based...
title: Contribution of diffusion-weighted MRI to conventional MRI in ovarian torsion: a prospective study for the detection of haemorrhagic infarction
Creators: name: OZDEMIR, OGUZHAN
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Emergency
subject: MR
subject: Imaging sequences

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: A delay in diagnosis ovary torsion may lead to significant morbidity and even mortality.Although detorsion with surgery may allow salvage of a viable ovary without critical complications, the salvage rate is reported to be below 10% in adults but as...
title: Correlation of diffusion-weighted apparent diffusion coefficient values with prognostic factors of invasive breast cancer
Creators: name: Úbeda Hernández, Belen
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: MR-Diffusion/Perfusion
subject: Molecular imaging
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Diffusion-weighted imaging (DWI) may identify biological heterogeneity of breast neoplasms. Apparent diffusion coefficient (ADC) values vary according to biological features of breast cancer. The purpose of this study was to correlate ADC values of...
title: Discrimination of malignant and benign breast masses using automatic segmentation and region of interest-based features extracted from MRI
Creators: name: Jiang, Xinhua
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: CAD
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: This study aimed to investigate whether combining morphology, texture features and kinetic features with diffusion-weighted imaging (DWI) using quantitative analysis improves the accuracy of discriminating malignant from benign breast...
Structure of Lambda(1405) and construction of KbarN local potential based on chiral SU(3) dynamics
Creators: name: Miyahara, Kenta
name: Hyodo, Tetsuo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We develop the single-channel local potential for the KbarN system, which is applicable to quantitative studies of Kbar bound states in nuclei. Because the high precision measurement of the kaonic hydrogen by SIDDHARTA reduces the uncertainty of the KbarN amplitude below the KbarN threshold, the local potential should be calibrated in a wide energy region. We establish a new method to construct the local potential focusing on the behavior of the scattering amplitude in the complex energy plane. Applying this method, we construct the KbarN potential based on the chiral coupled-channel approach with the SIDDHARTA constraint. The wave function from the new potential indicates the KbarN molecular structure of Lambda(1405).
description: 15 pages, 10 figures
title: Evaluation of neurovascular compression in trigeminal neuralgia using 3D-DRIVE MRI and correlation with surgical microvascular decompression
Creators: name: ElShafey, Mohamed
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: Imaging sequences

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Introduction Microvascular compression of the trigeminal nerve is the most common cause of trigeminal neuralgia (TN) which presents by recurrent painful episodes along the trigeminal sensory supply areas of the face. This is referred as...
(103389) William Arthur Bridge
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(103391) John Balmer Frazer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dwarf Galaxy $γ$-excess and 3.55 keV X-ray Line In A Nonthermal Dark Matter Model
Creators: name: Biswas, Anirban
name: Majumdar, Debasish
name: Roy, Probir
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent data from Reticulum II (RetII) require the energy range of the FermiLAT $γ$-excess to be $\sim$ $2-10$ GeV. We adjust our unified nonthermal Dark Matter (DM) model to accommodate this. We have two extra scalars beyond the Standard Model to also explain 3.55 keV X-ray line. Now the mass of the heavier of them has to be increased to lie around 250 GeV, while that of the lighter one remains at 7.1 keV. This requires a new seed mechanism for the $γ$-excess and new Boltzmann equations for the generation of the DM relic density. All concerned data for RetII and the X-ray line can now be fitted well and consistency with other indirect limits attained.
description: 8 eps figures, 1 Table, 7 pages. The paper has been completely rewritten with additional references and discussions of indirect constraints from AMS-02 and ANTARES data. Basic results remain unchanged. Version accepted for publication in Europhysics Letters
Structure-based discovery of potent and selective melatonin receptor agonists
Creators: name: Katritch, V.
name: Grandner, J.M.
name: Johansson, L.C.
name: Patel, N.
name: Stauch, B.
name: Liu, Y.
name: Roth, B.
name: Huang, X.P.
name: McCorvy, J.D.
Publisher: name: eLife Sciences Publications Ltd
Year: 2020

description: Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new ligand chemotypes using recently solved high-resolution 3D crystal structures of agonist-bound MT receptors. Experimental testing of 62 screening candidates yielded the discovery of 10 new agonist chemotypes with sub-micromolar potency at MT receptors, with compound 21 reaching EC50 of 0.36 nM. Six of these molecules displayed selectivity for MT2 over MT1 . Moreover, two most potent agonists, including 21 and a close derivative of melatonin, 28, had dramatically reduced arrestin recruitment at MT2, while compound 37 was devoid of Gi signaling at MT1, implying biased signaling. This study validates the suitability of the agonist-bound orthosteric pocket in the MT receptor structures for the structure-based discovery of selective agonists. © Patel et al.
Investigating outer membrane vesicular structure and function in Klebsiella pneumoniae
Creators: name: OBrien, Oliver Michael Coombs
Publisher: name: The University of Edinburgh
Year: 2019
Subjects: outer membrane vesicular structure
outer membrane vesicular function
Klebsiella pneumoniae
Outer membrane vesicles
Gram-negative bacteria
Mla pathway
OmpK35
OmpK36
lipid A LPS modifications
RamA transcriptional control

description: [No Deposit Agreement]
title: Breast arterial calcification on screening mammography can predict clinically significant coronary artery disease (CAD) in the BreastCheck screening cohort
Creators: name: Scanlon, Emer
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Cardiovascular system
subject: Mammography
subject: CT-Angiography
subject: Staging
subject: Contrast agent-intravenous
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Normal.dotm 0 0 1 60 345 Willow Park 2 1 423 12.0 0 false 18 pt 18 pt 0 0 false false false Coronary artery disease is a leading cause of death(1), risk factors have been identified(2) but many patients' first presentation is a cardiac event(3). The...