cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Suggested development plan Willingboro Township, New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1964

description: Some time ago the citizens and Township officials of Willingboro recognized the need for a plan to guide the future growth of the community into a harmonious and coordinated pattern of development. Consequently, the Planning Board undertook a program to prepare a comprehensive development plan. This plan is a compilation of written and graphic objectives for the future. Accordingly, it forms a basis for action both by citizens and officials of Willingboro.The plan attempts to shape a balanced community tied together by the inter-relationship of land uses, circulation and community facilities. Based upon this concept, certain areas of Willingboro have been designated for continued residential growth. It also recognizes the need for future commercial and industrial development with the retention of certain sites for recreational facilities. Community facilities have been strategically located to serve the Township in a convenient and economical manner. These have been inter-related with a circulation system to move traffic within and through Willingboro in a safe yet efficient manner.In order to arrive at this program, the development plan has formulated objectives which all citizens and officials of the Township should strive to achieve. Should these objectives change in the future, due to the constant review process necessary in such a long-range program, the plan should then be revised to keepcommunity objectives and proposals in proper perspective.Since the development plan is a guide for the future of Willingboro, and not a statutory document with legislative authority, its realization depends not only upon the Township Planning Board and local officials, but also upon all citizens of the Township. It is presented herewith in the form of a single document for review and evaluation by all concerned.
Megacera acuminata Galileo & Martins 2006
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Megacera
Megacera acuminata

description: Megacera acuminata Galileo & Martins, 2006
Galileo & Martins, 2006c:22, fig. 2.
Paratypes: ♂, ♀, BOLIVIA, Santa Cruz: Achira (Amboro, Campo 5-5), 9–11.X.2004, Wappes & Morris col. (MCNZ 234.874, 234.875).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 447, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Township of Willingboro Burlington County New Jersey, Willingboro development plan phase one: basic studies
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1963

description: This report represents the first phase of a development plan for Willingboro Township, covering existing development patterns, trends and evident problems. These studies should be helpful to the Township Council as well as the Planning Board in arriving at many of their day-to-day decisions, and will also be of assistance in determining a constructive and realistic program for the future development of the Township.
PARAMEDIAN FOREHEAD FLAP AS A RECONSTRUTIVE MODALITY: AN EXPERIENCE IN A TERTIARY CARE INSTITUTION
Creators: name: Priyanka Koushal
name: Rupal Sharma
name: Ratnakar Sharma
Publisher: name: Zenodo
Year: 2024
Subjects: Paramedian Forehead Flap, Nasal Defects, Eyelid Defects, Reconstruction.

description: Abstract

Forehead Flaps have been in use since ancient times as has been depicted in the classical paintings of  the great Susrutha at work repairing the nose of those unfortunate to have their noses cut off as a punishment. The Paramedian forehead flap is used not only for the reconstruction of  nasal defects, but it can be used for reconstruction of lid and cheek defects too. The flap is designed vertically and axially along the supratrochlear vessels.  A total of 25 patients undergoing reconstruction of nasal/ lid/cheek defects arising out of various reasons over a period of three years from June 2021 to May 2023  are presented.  All flaps survived and there were no complications encountered. The donor site in all the cases was closed primarily. Conclusion   The   paramedian forehead flap is a versatile flap for nasal and eyelid defects with an excellent colour match owing to proximity with the defect.
Exploring the Role of LINE-1 Retrotransposon Silencing in Cigarette-Related Lung Cancer Recurrence
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco smoking is associated with an increased risk of lung cancer recurrence. In fact, every pack year smoked translates to a roughly 1% increased risk of disease recurrence. Recurrence is a major clinical challenge in lung cancer, disproportionately affecting underserved California populations that exhibit increased tobacco smoking compared to the general population. However, the molecular mechanism responsible for tobacco smoking-induced lung cancer recurrence has not been elucidated. Recently it was shown that the transcriptional silencing of endogenous LINE-1 retrotransposons is essential for the generation of drug-tolerant persisters (DTPs), a subpopulation of tumor cells that survives chemotherapy treatment and initiates lung cancer recurrence. LINE-1 retrotransposons compose nearly 25% of the human genome and play crucial roles in maintaining the genomic integrity of cells. In preliminary studies, we found that the transcriptional silencing of LINE-1 retrotransposons in lung cancer cells is mediated by SUV39H1, an enzyme that promotes repressive H3K9me3 modifications on chromatin. Pharmacologic inhibition of SUV39H1 reactivated LINE-1 transcription in lung cancer cells, suggesting a potentially effective therapeutic approach to prevent DTP generation and disease recurrence. Importantly, we found that SUV39H1 is dispensable for LINE-1 transcriptional silencing in normal cells. We hypothesize that agents in tobacco smoke stimulate SUV39H1-mediated LINE-1 transcriptional silencing in lung cancer cells leading to increased DTP generation and disease recurrence. In this proposal, we will molecularly analyze lung cancer specimens from patients with known tobacco smoking histories and clinical outcomes to determine if tobacco smoke promotes SUV39H1-mediated LINE-1 transcriptional silencing and DTP generation. We will also determine if pharmacologic inhibition of SUV39H1 can prevent DTP generation and lung cancer recurrence caused by tobacco smoke by selectively inducing LINE-1 transcription in lung cancer cells. This research could identify SUV39H1-mediated LINE-1 transcriptional silencing as a driver of tobacco smoke-induced lung cancer recurrence and validate SUV39H1 inhibition as an effective therapeutic approach to prevent disease recurrence.
Lower Raritan/Middlesex County 208 water quality management planning program; DYLAM in the 208 process, report to the policy advisory committee
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1976

description: The Lower Raritan/Middlesex County 208 study team employed the Dynamic Land Use Allocation Model (DYLAM) as a tool in the planning process. DYLAM's function is to allocate future land use quantities within the study area. The actual areas to which land is allocated will depend on the region's characteristics and on public policies towards the direction and magnitude of future growth.Operation of DYLAM has begun and progress to date includes the compilation and coding of a land use inventory and the distribution of existing development types and attributes by grid square. Sample attributes maps and the 19&4 land use map are attached.
Come hug a tree with us; Big, interesting and historic trees, Boonton Township area
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2010

description: In 19&6, the Rockaway Valley Garden Club published a listing of Boonton Township’s significant trees. Over 30 years later, as part of the Rockaway Valley Garden Club’s ’Living Green' objectives, the Club has  updated and expanded this listing. The list includes: scenic trees, woodland trees, and prominent trees in alphabetical order by species.
Work plan for areawide waste treatment management planning under section 208 of PL 92-500
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1975

description: The proposed 208 Study represents an effort to approach several major water quality and supply related issues facing Lower Raritan/Middlesex County. The study covers a primary area including Middlesex County and certain contiguous watersheds for which full Section 208 planning would be accomplished.Specific research objectives of the work plan for both the basic and supplementary areas include:a. Acquisition of data as to point sources of pollution.b. Land use classification by watershed appropriate for water quality analysis.c. Data gathering as to runoff pollution from urban industrial areas and other nonpoint sources.d. Evaluation of aquifer/recharge area relationships relative to effect of land use on percolation rates and on ground water quality.e. Evaluation of possibilities of effluent disposal and urban runoff recharge relative to water quality effects on ground water.
Folsomia candida
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia candida

description: Folsomia candida (Willem, 1902)
– Isotoma candida Willem, 1902b: 280.
CE, TE, EA: Cox 1982; MAZ: Yahyapour 2012; Yoosefi Lafooraki et al. 2020b; GO: Yoosefi Lafooraki et al. 2020b; GI: Cox 1982; Yoosefi Lafooraki et al. 2020b; KU: Ahmadi et al. 2023.
Ecology and habitat in Iran: soil and leaf litter.
Remarks: Cox (1982) reported this species as Folsomia litsteri Bagnall, 1939 that is considered as a junior synonym of F. candida.
General distribution: cosmopolitan (Potapov 2001; Fjellberg 2007).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 42, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Hippopsis tuberculata Galileo & Martins 1988
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Hippopsis
Hippopsis tuberculata

description: Hippopsis tuberculata Galileo & Martins, 1988
Galileo & Martins, 1988a:181, figs 4–7.
Paratypes: ♂, BRAZIL, Minas Gerais: Viçosa, 12–15.II.1939, Martins & Colytocis col. (MCNZ 64.971); ♂, Espírito Santo: Barra do São Francisco (Córrego Itá), XI.1956, W. Zikán col. (MCNZ 64.972).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 447, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Reprogram nicotine exposed hematopoietic stem cells to inhibit stress induced megakaryopoiesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We want to know why tobacco smokers are more likely to get strokes or heart attacks due to blocked blood vessels. What happens in the blood of these people that is different from non-smokers?
 Platelets are small blood cells that help our bodies stop bleeding by forming clots. Platelets, like all other blood cells, are formed by blood stem cells. Our lab discovered that blood stem cells in older mice, whose body responds similarly to exposure to nicotine, make a set of unique platelets that may contribute to the likelihood of getting strokes and heart attacks. We want to understand what signals cause blood stem cells of nicotine-exposed mice to make these dysfunctional platelets. Then, we will use special mice we have in the lab to block these signals so that the nicotine-exposed blood stem cells stop making dysfunctional platelets. This will allow nicotine-exposed blood stem cells to start working as if they had never been exposed to nicotine, which will prevent strokes and heart attacks in these mice.
 If we understand how nicotine-exposed blood stem cells make dysfunctional platelets, scientists can develop new therapies that stop this from happening. Eventually, doctors can prescribe smokers these medicines to revert the damage caused by smoking so that they don’t have to be afraid to get strokes or heart attacks. And if they do get strokes or heart attacks, these medicines can help the patients feel and heal better.
Lower Raritan/Middlesex 208 water quality planning program; Summary: inventory of point sources
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1976

description: The inventory includes an alphabetic index of major and minor pollutant dischargers, a numerical index of major and minor pollutant dischargers, a treatment coding glossary, summary tabulation of major and minor dischargers by receiving stream and a location map.
Trichohippopsis exilis Galileo & Martins 2006
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Trichohippopsis
Trichohippopsis exilis

description: Trichohippopsis exilis Galileo & Martins, 2006 [current name: Trichohippopsis gilmouri (Breuning, 1962)].
Galileo & Martins, 2006c:22, fig. 1; Galileo & Santos-Silva, 2016:365 (syn.)
Paratype ♀, BOLIVIA, Santa Cruz: Achira (3,7 km SSE, Hotel Flora & Fauna, 430 m), 15–22.XI.2001, M. C. Thomas & D. K. Dozier col., “ blacklight trap, tropical transition forest” (MCNZ 234.873).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 447, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
MPEC 2024-J285 : 2024 JE15
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 JE15

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Folsomia diplophthalma
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia diplophthalma

description: Folsomia diplophthalma (Axelson, 1902)
– Isotoma diplophthalma Axelson, 1902: 106.
KE: Abdolalizadeh 2018; Abdolalizadeh et al. 2018, 2019.
Ecology and habitat in Iran: soil of cherry garden.
General distribution: Palaearctic (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 42, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Additional file 16: Table S5. of Sequence-based prediction of permissive stretches for internal protein tagging and knockdown
Creators: name: Oesterle, Sabine
name: Roberts, Tania
name: Widmer, Lukas
name: Mustafa, Harun
name: Panke, Sven
name: Billerbeck, Sonja
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Plasmids used in this study. (DOCX 136 kb)
Folsomia fimetaria
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia fimetaria

description: Folsomia fimetaria (Linnaeus, 1758)
– Podura fimetaria Linnaeus, 1758: 609.
CE, MAZ, TE, GI: Cox 1982.
Ecology and habitat in Iran: soil and leaf litter.
General distribution: Holarctic (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 42, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Women in social service
Creators: name: Campbell, Margaret
Publisher: name: No Publisher Supplied
Year: 1945

description: Focuses on three women in social service: Jane Addams, founder of Hill House, Evangeline Booth, general of the Salvation Army, and Mother D'Youville, founder of the Sisters of Charity, the Grey Nuns of Montreal.  Presented are biographical facts and extensive character description at several stages in each of their lives.
Additional file 17: Table S6. of Sequence-based prediction of permissive stretches for internal protein tagging and knockdown
Creators: name: Oesterle, Sabine
name: Roberts, Tania
name: Widmer, Lukas
name: Mustafa, Harun
name: Panke, Sven
name: Billerbeck, Sonja
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Primers used in this study. (DOCX 164 kb)
The deleterious effects of nicotine and e-cigarette flavorants on lung mesenchymal stem cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is a well-known risk factor for many lung diseases, affecting millions of people in California. How cigarette smoking causes lung diseases is not completely understood. It was assumed that electronic delivery (e-cigarette) of nicotine, a major component in tobacco, would be relatively safe compared to cigarette smoke that contains thousands of toxic chemicals. However, clinical and laboratory studies have confirmed that e-cigarette vaping also causes lung damage and diseases. In particular, a nationwide outbreak of e-cigarette or vaping product-use-associated lung injury was reported last year. Thus, a thorough investigation about the toxicity of nicotine and new flavoring chemicals added to e-cigarettes is urgently needed. As we know, normal lung structure and function are maintained by appropriately repairing damaged tissue, and stem cells play key roles in mediating tissue repair. One of the important stem cells in the lung are called mesenchymal stem cells (MSCs), which are essential to promoting lung growth and maintenance. In this project, we will first examine nicotine and flavoring agents to see if they have toxic effects on mouse lung MSCs in culture. Then, we will detect the changes in lung MSCs in mice exposed to cigarette smoke or e-cigarette vapor, a situation mimicking human cigarette smoking or e-cigarette vaping. The alterations of lung MSC number and activity will then be linked to lung structural damage. Using different experimental approaches, the results of this study will be the first to tell whether nicotine and/or flavoring chemicals are toxic to lung MSCs and the relationship of this toxicity to lung damage and diseases. This will help us to understand how tobacco products cause lung diseases, and provide scientific evidences to support new and stringent tobacco control policy.
Folsomia inoculata Stach 1947
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia inoculata

description: Folsomia inoculata Stach, 1947
– Folsomia inoculata Stach, 1947: 34.
MAZ: Yahyapour et al. 2020a.
Ecology and habitat in Iran: soil and leaf litter.
General distribution: Holarctic (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 42, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Caciomorpha robusta Galileo & Martins 1998
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Caciomorpha
Caciomorpha robusta

description: Caciomorpha robusta Galileo & Martins, 1998
Galileo & Martins, 1998b:21, figs 6, 7, 14, 24.
Paratype ♀, BRAZIL, Amazonas: Benjamin Constant (Rio Javari), XI.1960, Dirings col. (MCNZ 233.939).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 447, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Adetus cecamirim Martins & Galileo 2005
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Adetus
Adetus cecamirim

description: Adetus cecamirim Martins & Galileo, 2005
Martins & Galileo, 2005b:26, fig. 2.
Paratype ♀, BOLIVIA, Santa Cruz: Buena Vista, (4–6 km SEE Hotel Flora & Fauna), 08.XI.2002, J. E. Wappes col. (MCNZ 233.940).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Talking technology: exploring chatbots as a tool for cataract patient education
Creators: name: Yılmaz, İ̇brahim Edhem
name: Doğan, Levent
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Hematology

description: Worldwide, millions suffer from cataracts, which impair vision and quality of life. Cataract education improves outcomes, satisfaction, and treatment adherence. Lack of health literacy, language and cultural barriers, personal preferences, and limited resources may all impede effective communication. AI can improve patient education by providing personalised, interactive, and accessible information tailored to patient understanding, interest, and motivation. AI chatbots can have human-like conversations and give advice on numerous topics. This study investigated the efficacy of chatbots in cataract patient education relative to traditional resources like the AAO website, focusing on information accuracy,understandability, actionability, and readability. A descriptive comparative design was used to analyse quantitative data from frequently asked questions about cataracts answered by ChatGPT, Bard, Bing AI, and the AAO website. SOLO taxonomy, PEMAT, and the Flesch-Kincaid ease score were used to collect and analyse the data. Chatbots scored higher than AAO website on cataract-related questions in terms of accuracy (mean SOLO score ChatGPT: 3.1 ± 0.31, Bard: 2.9 ± 0.72, Bing AI: 2.65 ± 0.49, AAO website: 2.4 ± 0.6, (p < 0.001)). For understandability (mean PEMAT-U score AAO website: 0,89 ± 0,04, ChatGPT 0,84 ± 0,02, Bard: 0,84 ± 0,02, Bing AI: 0,81 ± 0,02, (p < 0.001)), and actionability (mean PEMAT-A score ChatGPT: 0.86 ± 0.03, Bard: 0.85 ± 0.06, Bing AI: 0.81 ± 0.05, AAO website: 0.81 ± 0.06, (p < 0.001)) AAO website scored better than chatbots. Flesch-Kincaid readability ease analysis showed that Bard (55,5 ± 8,48) had the highest mean score, followed by AAO website (51,96 ± 12,46), Bing AI (41,77 ± 9,53), and ChatGPT (34,38 ± 9,75, (p < 0.001)). Chatbots have the potential to provide more detailed and accurate data than the AAO website. On the other hand, the AAO website has the advantage of providing information that is more understandable and practical. When patient preferences are not taken into account, generalised or biased information can decrease reliability.
Elucidating the role of PEA3 transcription factors in progression of small cell lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Small cell lung cancer (SCLC) is an incredibly aggressive subtype of lung cancer that has a tendency to spread from the lungs to other, more distant sites of the body very early on in the course of disease. While the treatment that we use for this disease works extremely well for a large majority of patients, the disease almost invariably develops resistance. Because of this, the overall 5-year survival rate for patients with this disease is only 6%. Many studies have tried to identify mutations that might explain why SCLC becomes resistant so quickly, but these studies have not yet resulted in new therapies. We wanted to conduct a study to better understand the molecular changes that occur over time with the hopes of identifying genes or proteins that may promote survival of SCLC cells following chemotherapy. We grew these cells and treated them with chemotherapy used in human patients and saw extensive cell death over the course of a week. However, when we extended these cell cultures by an additional two to three weeks, we saw that cells were indeed growing out. We decided this might be an appropriate model to try an understand the molecular changes that happen across SCLC cells as they respond to chemotherapy and then recover. We applied state-of-the-art sequencing technologies to profile the genes that are expressed in SCLC cells over time and used a combination of analysis methods to identify genes that were enriched specifically in the persisting cell population that evaded cell death. We have found that a subgroup of transcription factors becomes highly enriched in these persisting cells and are interested in further studying whether these factors are important in allowing these persisting cells to survive and regrow. Furthermore, we have found evidence in the literature for these factors mediating cancer metastasis in other types of cancer and want to study whether these genes also play a role in mediating metastasis in SCLC.
Additional file 1: Table S1. of Sequence-based prediction of permissive stretches for internal protein tagging and knockdown
Creators: name: Oesterle, Sabine
name: Roberts, Tania
name: Widmer, Lukas
name: Mustafa, Harun
name: Panke, Sven
name: Billerbeck, Sonja
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Mapping of known permissive sites within TpiA and Bla. A known permissive site (first column, given as residue number) within TpiA and Bla [32] was assigned to a predicted stretch (PS) if it mapped directly within a PS (see Additional file 3: Figure S1 for illustration) or if it was shifted by few residues but at least mapped to the same secondary structural element (“scattered” permissive sites). The number of residues by which a given “scattered” site is shifted is given in column 5. Note that, due to the experimental approach, which selected for only functional protein variants, there are no known non-permissive sites for TpiA. (DOCX 90 kb)
My Irish roots
Creators: name: Campbell, Margaret
Publisher: name: No Publisher Supplied
Year: 1978

description: Early Irish history through reminiscences of a personal trip in 19&5 exploring megalithic tombs. Family history of the Dalys and the Mansfields from Ireland to New Brunswick, NJ. Memories of Irish in New Brunswick. Facts and anecdotes of Judge Daly through his New Brunswick and Middlesex County political career.
Adetus inca Martins & Galileo 2005
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Adetus
Adetus inca

description: Adetus inca Martins & Galileo, 2005
Martins & Galileo, 2005b:26, fig. 3.
Paratype ♀, BOLIVIA, Santa Cruz: Achira (5400–5800 pés), 20.XI.2003, Wappes, Morris & Nearns col. (MCNZ 233.941).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Investigating the potential for non-tobacco wraps to displace cigarillos for blunt smoking
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking marijuana from a cheap cigar, whose tobacco is replaced with marijuana, became a popular activity in the 1990s among young, urban African-Americans who had experienced the devastating effects of crack cocaine. This activity, referred to as blunt smoking, has expanded to other racial/ethnic groups in recent years. Tobacco companies have marketed the cheap cigars, mainly cigarillos, for blunt smoking as evidenced by references to cannabis (e.g., Cali Green). Furthermore, the availability of several flavors of cigarillos, small pack sizes, and low taxes have appealed to individuals who partake in blunt smoking. But, blunt smokers’ use of cigarillos may be displaced by a new line of products that are made from hemp, palm leaves, and other non-tobacco sources. The non-tobacco wraps might become more popular as cities and counties throughout California ban flavored tobacco because some brands of hemp wraps are sold in a variety of flavors. While various magazines promoting marijuana may tout the non-tobacco wrap as the “next big thing”, studies are needed to assess whether blunt smokers are receptive to using the non-tobacco product as a replacement for the cigarillo. The current project is intended to assess the likelihood of blunt smokers’ transition to non-tobacco wraps through an examination of informal conversations on Twitter, and actual conversations with groups of blunt smokers. These conversations will address blunt smokers’ thoughts about accessibility and product characteristics of non-tobacco wraps, including ease of rolling, burn quality, flavor/aroma, taste, and price. In addition, blunt smokers will be asked if they perceive the non-tobacco wraps as a less harmful alternative to the cigarillo. The broad goal of this project is to assess whether marijuana accessories, namely non-tobacco wraps, have the potential for breaking the connection between tobacco and marijuana. The findings from this project could lead to a larger investigation of how companies market the non-tobacco wraps to marijuana smokers.
Chemical Proteomics Manipulation of RNA Binding Proteins in Non-Small Cell Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking associated non-small cell lung cancer (NSCLC) is a leading cause of death worldwide but remains notoriously challenging to treat. The average survival rate of NSCLC remains below 20%. Therefore, there is a fundamental need for the identification of new disease-linked proteins and pathways that can be targeted therapeutically. One such exciting class of proteins are RNA binding proteins (RBPs). Recent studies have identified multiple RBPs that contribute to the initiation and progression of NSCLC. However, RBPs are considered "undruggable", and currently no small druglike molecules, often called chemical probes, are available to alter the functions of any RBP. My research will develop new methods to identify chemical probes targeting RBPs, as a novel strategy to guide the production of future therapies to treat NSCLC. In this study I will identify chemical probes that react with the amino acid cysteine in NSCLC-associated RBPS. Cysteine is an important amino acid to study because many drugs can be designed to specifically target it and combat cancer. Our previous data showed that many RBPs contain reactive and potentially druggable cysteines. In this study I will use our lab's cysteine mapping proteomic methodology to identify targetable cysteines in RBPs. Next, I will develop new chemical tools to capture and assay the functions of RBPs and will apply these new tools in combination with our cysteine-reactive probes to determine how chemical labeling alters RBP function. Finally, we will assay whether some of the cysteine residues that we identify contribute to NSCLC growth, migration, and invasion, which are indicators of metastatic activity. Taken together, our study will develop new tools for studying the functions of RBPs and will identify druggable pockets in RBPs, including RBPs that contribute to NSCLC.
Retinal vessel diameters in intermediate age-related macular degeneration using en face optical coherence tomography
Creators: name: Nivison-Smith, Lisa
name: Faiza, Alvia
name: Roy, Tithi
name: Trinh, Matt
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Clinical assessment of age-related macular degeneration (AMD) relies on biomarkers that do not necessarily reflect the contributions of vascular dysfunction. Validation of clinically accessible methods of measuring retinal vascular integrity could provide a more holistic understanding of AMD-related changes to facilitate appropriate care. There is conflicting evidence if retinal vessel calibre is significantly altered in the early stages of AMD. This study examined the outer and inner diameters of first order retinal vessels in intermediate AMD eyes using en face optical coherence tomography (OCT). Retinal en face (6 × 6 mm) OCT images were examined in a single eye of participants with intermediate AMD (n = 46) versus normal macula (n = 43) for arterioles (all identifiable) and venules (40/46 and 39/43 identifiable). All participants were aged ≥50 years without diabetes mellitus, hypertension, or other systemic vascular disease. Intra- and inter-grader agreement was good-to-excellent for all en face OCT measurements of arteriole and venule diameters (intraclass correlation coefficient = 0.87 to 0.99). Arteriolar outer diameters (82.3 ± 19.8 µm vs 73.8 ± 16.1 µm; p < 0.05) and inner diameters (35.1 ± 8.4 µm vs 31.5 ± 8.1 µm; p < 0.05) were significantly greater in AMD eyes compared to normal eyes. Venular inner diameter was significantly greater (43.1 ± 9.5 µm vs 39.2 ± 10.1 µm; p < 0.05), but outer diameter remained unchanged (p = 0.17) in AMD eyes compared to normal eyes. Arteriolar dilation and altered venular inner diameter were observed in intermediate AMD eyes. These results support further investigation of vascular contributions to AMD in the early stages of disease, possibly using the en face OCT imaging modality.
Wearable Sensors to Monitor Exacerbation Risk In Chronic Obstructive Pulmonary Disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic Obstructive Pulmonary Disease (COPD) affects 15.7 million Americans and is the 4th leading cause of death in the USA. COPD costs the US economy ~$50 billion per year. The main driver of these costs are exacerbations requiring hospitalization, caused by a lung infection and resulting in a worsening of symptoms.

 We desperately need improved strategies for early detection of an impending COPD exacerbation. Early detection would allow patients to be treated sooner, e.g. with steroids or antibiotics, and would reduce the number of COPD patients requiring hospitalization. Measurement of chemicals and proteins in the blood (“biomarkers”) that are related to infection and inflammation improves the ability to detect COPD exacerbations and predict poor outcomes. Frequent (e.g. daily) collection of patient blood samples is not practical, but sweat also contains these biomarkers. Therefore, this pilot study will establish the viability of a cost-effective sweat sensor to be worn on the wrist, which can assess COPD-related inflammatory biomarkers in sweat as a potential monitoring system to warn patients of impending COPD exacerbation and/or to seek physician consultation. Because these biomarkers also respond to physical activity, we propose to determine the reliability and validity of the developed sweat sensor in COPD patients hospitalized for a COPD exacerbation and in outpatient subjects with and without COPD during and following exercise. Five specific biomarkers have been chosen for their potential to allow specific identification of impending exacerbation. We will: 1) Develop a wearable sweat sensor that can induce sweat, measure biomarkers and send the information wirelessly to a phone or tablet; 2) Validate the ability of the sensor to measure biomarkers in patients hospitalized for COPD exacerbation by comparing blood and sweat values; and 3) Validate the sensor in stable COPD patients and controls during and following exercise.

 The ultimate aim of these studies is to develop a system to preempt COPD exacerbations, reduce patient mortality and hospitalization risk and healthcare utilization. As such, this sensor platform has the potential to not only revolutionize COPD management, but also to significantly impact the healthcare industry by incorporating the use of wearable electronics into chronic disease management.
Amphicnaeia armata Galileo & Martins 2001
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Amphicnaeia
Amphicnaeia armata

description: Amphicnaeia armata Galileo & Martins, 2001
Martins & Galileo, 2001:38, fig. 4nh.
Paratype: 1 specimen, BRAZIL, Paraná: Lapa (1300 m), 13.I.1967, E. Amante col. (MCNZ 233.943).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Safety of nuclear reactors, or, Is standing on a soapbox really safe?
Creators: name: Joyce, Ann
Publisher: name: No Publisher Supplied
Year: 1978

description: Argues that nuclear energy plants are necessary for America and that the safety of these plants will be assured by future developments. The paper's author, Ann Joyce, is the daughter of the man who developed the atomic submarine; her husband was chief engineer at Princeton's fusion experiment. Ralph Nader's concerns in the mid 1920s are addressed, point by point. The author asks how many nuclear accidents could you name in 19&8, when the paper was written. Note: The paper was written shortly before Three Mile Island.
Repurposing GPCR-targeted drugs for the treatment of pancreatic cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco smoking is a major risk factor for Pancreatic Ductal AdenoCarcinoma (PDAC), the most frequent and lethal type of pancreatic cancer. PDAC arises from the tube (duct) that carries fluids and proteins from the pancreas to the intestine as part of the digestion of foods. Currently, over 90% of PDAC patients die within 5 years of diagnosis; it is estimated that more than 47,000 people will die in 2020 from PDAC. New, effective treatments for PDAC patients are thus an important, unmet medical need. We seek to address this need by determining if drugs already approved by the Food and Drug Administration (FDA) for other conditions might be re-purposed for the treatment of PDAC. Because such drugs have already been tested in people, features of their actions, including their side-effects, are well-understood. As a result, health providers are familiar with their use and such drugs can enter clinical trials much faster than newly discovered drugs/ If effective and safe, such drugs could be new ways to treat PDAC. We have recently found that PDAC tumors express much higher levels than the normal pancreas of certain binding sites (known as receptors) on the surface of PDAC cells. These receptors detect particular chemicals found in the blood and tissues. Moreover, FDA-approved drugs (inhibitors) of these receptors blunt their activity and are used to treat other conditions. We will test if such FDA-approved inhibitors might be re-purposed to treat PDAC. First, we will confirm that the receptor proteins are present on PDAC cells and test if the chemicals that activate the receptors alter the function (such as growth and movement) of PDAC cells. Then, we will test if the FDA- approved inhibitors blunt those altered functions of PDAC cells. Next, we will determine if the FDA-approved inhibitors can promote the killing of PDAC cells, including when tested with drugs that are currently used to treat PDAC patients. In other studies, we will test if the FDA-approved inhibitors shrink PDAC tumors in mice. Success in the proposed studies would set the stage for further efforts, including what we believe could be the rapid initiation of clinical trials of the re-purposed FDA-approved drugs for the treatment of PDAC--a tobacco-related, highly lethal disease with a strong need for new therapeutics.
Folsomia ksenemani Stach 1947
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia ksenemani

description: Folsomia ksenemani Stach, 1947
– Folsomia ksenemani Stach, 1947: 134.
MAZ: Yoosefi Lafooraki 2014; Yoosefi Lafooraki & Shayanmehr 2014a, b; TE: Qazi & Shayanmehr 2016b.
Ecology and habitat in Iran: soil and leaf litter under plum, acacia and oak trees.
General distribution: Europe, West Caucasus, Lebanon (Potapov 2001) and Iran.
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 42, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Predicting Environmental Waste from Tobacco, Electronic Cigarette, and Marijuana Products
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Litter from the use of tobacco (T), electronic smoking/vaping devices (E), and marijuana (M) contributes large amounts of hazardous waste to the environment. This waste includes biohazards and electronic hazards such as plastic filters, unsmoked and charred tobacco and marijuana, batteries, electronic components, pods, cartridges, and parts of vape pens, as well as packaging. From streets, parking lots, and neighborhood parks, this waste ends up in landfills or flows into storm drains, and eventually reaches rivers, lakes, marshes, and beaches. Research has shown that harmful chemicals leach from discarded cigarette butts, batteries, and vape pods that are harmful to the environment and may enter the human food chain. Cleanup costs associated with TEM waste are borne by local communities, taxpayers, and voluntary groups. But cleanup efforts provide only a temporary remedy and more effective strategies are needed. The proposed study will (1) create map of TEM waste in in eight communities of San Diego County based on neighborhoods TEM waste surveys, (2) develop a predictive model of TEM waste based on socioeconomic, land-use, and health risk behavior, and (3) work with communities to share findings, identify the reasons for, and explore remedies to eliminate TEM waste. To achieve these goals, we will examine N=120 city blocks in select census tracts of San Diego County. For Aim 1, research assistants and community volunteers will conduct standardized surveys to collect and measure TEM waste. For Aim 2, we will examine if the amount and type of waste found in neighborhoods is associated with demographic (e.g., income), land-use (density, restaurants, tobacco resale businesses), and health risk behaviors (e.g., smoking). For Aim 3, we will share findings with local communities to explore reasons for TEM waste and potential remedies. If successful, findings from this study could be tested and applied in other urban areas of California. This study will engage local communities and governments to address TEM waste and help protect local neighborhoods and California’s aquatic environments from the toxic legacy of TEM use.
Cults
Creators: name: Stuart, Betty
Publisher: name: No Publisher Supplied
Year: 1979

description: Covers the basic outline for recruiting and financing of several cult organizations: the Children of God) active in California), the New Testament Missionary Fellowship (focus on Yale University students), the Church of Armageddon in Seattle, Washington, the Hara Krishnas, and the Unification Church of Rev. Sun Myung Moon. Also has accounts of deprogramming undertaken by Ted Patrick in the early 19&0s.