cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Classification of cat ventrolateral spinal axons and their response to an itch-producing stimulus (cowhage).
Creators: name: Wei, Jen Yu
Publisher: name: University of Utah
Year: 2012
Subjects: Neural Stimulation
Itching
Spinal Nerves
Cats

description: Unit activity was recorded from 92 ventrolateral spinal axons in seven anemically decerebrated spinal cat preparations, using a microdissection technique. Axons were classified into four categories according to their responsiveness to mechanical stimuli applied to skin and/or other tissues: (1) low threshold spinal axons (5%), (2) wide dynamic range spinal axons (57%), (3) high threshold spinal axons (23%), and (4) an "other" category which included axons responding to mechanical stimulation applied to visceral or deep tissue and axons responding to changes in limb or tail position.  Sixty-one of the 92 spinal axons had an ongoing resting discharge. Hence, they were divided into three types on the basis of their resting discharge pattern: (1) units with no resting activity (34%), (2) units with intermittent resting discharge (23%), and (3) units having continuous resting discharge (43%). Consequently, each category of mechanically sensitive ventrolateral spinal axons was further subgrouped on the basis of resting discharge.  In general, the fields of low threshold spinal axons were large and bilateral; the fields of wide dynamic range spinal axons were intermediate in size and ipsilateral; and the fields of high threshold spinal axons were small and contralateral.  The approximate location in the ventrolateral spinal white matter of different categories of spinal axons was mapped but no significant segregation was found. A comparison was made between different categories of mechanically sensitive ventrolateral spinal axons to determine their sensitivity to the itch-producing stimulus, cowhage. The wide dynamic range spinal axons were significantly affected. Of 34 wide dynamic range units which were tested, 23% demonstrated a relatively high sensitivity to cowhage and hence might be regarded as pruritogen-responsive spinal axons. Sixty percent of the pruritogen-responsive units had an intermittent resting discharge pattern.  Cowhage was applied on 14 high threshold and three low threshold ventrolateral spinal axons but no significant effect was demonstrated.
Sonnenfleckenzeichnung Nr. 23388.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Comparison of U-tube boreholes and a thermosiphon on heat pump performance in an aquifer
Creators: name: Workman, Christopher B.
Publisher: name: University of Utah
Year: 2012
Subjects: Borehole
Heat pump
Thermosiphon
U-tube
Geothermal systems

description: Reducing our energy consumption and dependence on fossil fuels has become a common social, political and engineering goal. Heating and cooling of buildings  account for a large percentage of the energy consumption in the United States. Improving HVAC efficiency in buildings can play a major role in reducing energy use.  Small scale geothermal systems that utilize low-grade heat have gained popu-larity as a way to reduce HVAC energy consumption. U-tubes and thermosiphons  are two di fferent technologies designed to transfer heat to and from the ground in order to provide building heating and cooling.  This thesis presents a short and long term experimental analysis. The short term analysis compares the performance of these technologies. The long term analysis focuses on the U-tubes, looking at the COP of the overall system during the course of a heating season and comparing temperatures for a theoretical air source heat pump system.
Sonnenfleckenzeichnung Nr. 23364.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23426.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.08.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23424.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.08.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Relationship between reported health status of Job Corpsmen and their use of health care service
Creators: name: Westenhaver, James Conway
Publisher: name: University of Utah
Year: 2012

description: The relationship between the reported health status of 92 Job Corpsmen and their use of health care services at Clearfield Job Corps, Clearfield, Utah, was studied by interviewing each student using a thirty-one item questionnaire in regard to the following broad areas:  their present reported health status, whether or not they use the clinic after the initial medical examination, the reasons for their subsequent use of the clinic.  When on controls for sex and educational level, a statistically meaningful relationship between reported health status and the use of the clinic doe not exist.  However, when one control for ethnic background, there is a relationship, but only when American Indian, Southeast Asian, and Spanish-speaking student are grouped together and contrasted to whites and blacks.  Twenty-three percent of the representative sample of 1,450 students at Clearfield have one or more diseases.  Acute bronchitis represents 62% of the most common health problems (52% of the males; 73% pf the females).  Utilization levels are uneven ethnic categories.  Eighty-six percent of the student use the clinic, whereas only 58 of the Southeast Asian student go to the clinic after the initial examination.  The Southeast Asian student makes less than 2.0 visits per length of stay at Clearfield, in comparison to twice as many visits for any of the other cultures represented.  Possibly the utilization level of the Southeast Asian student is due to a concept of disease that is contrary to the Western biomedical concept employed by the clinic.  This possibility is further suggest by the Southeast Asian student's preference for staff who "speak their language," which would include an understanding of a Southeast Asian's concept of disease.  What has just been said also applies to the American Indian, and to a lesser extent to the Spanish-speaking male (but not the female).  Policies and procedures that are operational in the clinical may have a negative influence on the level of utilization by the students.  This suggested by a strong interest in changing the sick call hours, doing away with the referral system or modifying it, and providing services in a friendly and timely manner.
The relationship between psychiatric nurses' communication skills and patients' evaluations of their nursing care.
Creators: name: Simpson, Susan
Publisher: name: University of Utah
Year: 2012
Subjects: Communication
Nurse and Patient

description: The present study tested the assumption that an environment conducive to therapeutic experiences is largely determined by the nurse's ability to give understanding, helpful responses in the nurse-psychiatric patient interaction.  It was expected that there would be a significant correlation between the nurse's ability to give understanding.  Helpful responses and the patients' positive evaluation of the therapeutic care they were receiving from professional nurses during their hospitalization.  Ellsworth's Patients Opinion of the Ward Protocol (1966) was revised to apply to "nursing personnel" specifically rather than "ward Personnel" in general and administered to all available patients on the psychiatric divisions of seven Utah hospitals.  Patients participating in the study did so, on a voluntary basis.  One hundred ten patient protocols were obtained, of which thirteen were eliminated on basis of being unreliable and invalid.  Jensen's Nurse-Psychiatric Patient Interaction Inventory (1966) was administered to 44 professional nurses working on the 10 psychiatric divisions of the 7 hospitals.  Each of the patient protocols was scored individually on eight factor solution and the mean score for each factor was obtained for the ten psychiatric wards.  These means were used as measures of the patients' typical satisfaction with their psychiatric nursing care.  A mean score on the NPPII was obtained for each of the then psychiatric wards.  These means were used as the measures of the quality of the nurses' verbal responses to psychiatric patients.  Rho correlations were calculated between each of the POW factor scores and the NPPII scores for the ten wards.  None of these correlations were significant.  This failed to support the expectation that there would be a significant correlation between the nurses' ability to give understanding, helpful responses and the patients' positive evaluation of the therapeutic care they were receiving from professional nurses during their hospitalization.  Various possible reasons for the lack of correlations were discussed.
Potent 3-methylindole-mediated DNA damage, cytochrome P450 induction, and mutagenicity in human lung
Creators: name: Weems, Jessica Marie
Publisher: name: University of Utah
Year: 2012
Subjects: 3-methylindole
3MI
DNA damage
Mutagenesis
Carcinogen
Mutagenicity
Lung cancer
Pneumotoxicants
CYP450
Cytochrome P450 enzymes

description: 3-methylindole (3MI) is a preferential pneumotoxicant known to be present in cigarette smoke at  concentrations previously demonstrated to cause pulmonary damage in experimental animals. Human cytochrome P450 (CYP450) enzymes, including 1A1, 2A13, and 2F1 catalyze the dehydrogenation of 3MI to the reactive intermediate 3-methyleneindolenine (3MEIN). This metabolite alkylates DNA. Alkyl DNA adducts have previously been demonstrated to play a role in the induction of xenobiotic-mediated apoptosis, mutagenesis, and carcinogenesis. In addition, 3MI induces the expression of cytochrome P450 enzymes in experimental animals. owever, the ability of 3MI to  induce these effects in human lung has not been elucidated to date. The hypothesis for this work is that cytochrome P450-mediated metabolism of 3MI causes DNA damage, cytochrome P450 induction, and mutagenesis in human lung.
Sonnenfleckenzeichnung Nr. 23523.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.12.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Residual welding stress in medium and highly restrained weldments
Creators: name: Komlos, William A
Publisher: name: University of Utah
Year: 2012
Subjects: Residual stresses
Welded joints

description: Restrained welded structures hold significant residual strains that preload the  structural system, robbing the structural capacity expected by design. Shrinking weld  metal and thermal joint displacement combine to create residual stress in the welded  connections. Residual welding stress combines with other processing stresses remaining  in the individual members or preassembled components. Whether the combinations of all  residual stresses result in a compressive or tensile applied force depends upon the  geometry of the structural members and the direction of applied internal loads.  Regardless of magnitude, residual stresses become part of the forces applied during  service. Safety factors incorporated into structural design, typically 1.65, are thought to  address the impact of residual stress.  Residual welding stresses in heavy weldments are tensile in all three planes. The  reaction of the massive joint against displacement increases the magnitude of resultant  tension. Tension along all three axes, triaxiality, promotes a state of plane-strain stress in  the weldment. Steels at plane-strain stress, where metal cannot stretch or yield, can fail at  loads below those anticipated by design. Triaxial tension reduces the ductility of  structural systems.  The heat of the welding arc drives residual welding stress. The hottest spot is  located immediately beneath the arc and temperatures decrease to ambient temperatures  at some distance from the weld. Cooling rates are very fast under the arc but slow in the  regions surrounding the arc as the thermal gradient declines. The welding arc furnishes  the energy that causes the weld metal to shrink and the surrounding base metal to expand  at the same time.  Welding Codes identify three joint restraint conditions: low, medium, and high.  Production costs increase dramatically as joint restraint increases. No welding Code,  however, offers defining attributes for restraint conditions. This thesis evaluates residual  strain in a moment-frame while welding the beam-to-column connections. Data obtained  during three experiment series describe the welding effects on pinned and fixed joint  configurations. Experimental data will characterize joint restraint in medium and highly  restrained connections. A structural analysis of an actual large-span truss shows the effect  of numerous small displacements at each truss connection node.
A grounded legal study of the breakdown of modders' relationships with game companies or legal threats shake moral beds
Creators: name: Altizer, Roger Alan Jr.
Publisher: name: University of Utah
Year: 2013
Subjects: cease and desist
chilling effect
grounded theory
modding
participatory culture
video games

description: This dissertation utilizes law and society research, as well as communication advocacy, to frame analysis and offer an extra-legal solution to conflicts between modders, fans who create new content from existing videogames, and game companies. It utilizes grounded theory and the traditional legal adversarial documentary method to abstract and analyze conflict caused by a cease and desist (C&D) letter sent to Kajar Laboratories concerning Chrono Trigger: Crimson Echoes - Kajar's mod to Square Enix's Chrono Trigger. Through qualitative analysis of websites, forum posts, and blog comments about the C&D this dissertation discovers the grounded theory Legal Threats Break Moral Communities. Utilizing the grounded theory and legal argumentation a critique is made of proposed legal solutions. A nonlegal solution to ameliorate future conflict is then suggested as a means to satisfy both the needs of modders and game companies. In analyzing the conflict this dissertation illustrates how the threat of law stops modders, disrupts the community, and chills future mods. This dissertation reinforces a regulatory understanding of copyright law arguing limited monopolies on intellectual property serve to advance the arts and sciences. Modding, like many forms of participatory culture, promotes valuable science, technology, engineering, and math through self-learning. Mods promote the original games while also generating new art. The dissertation also shows that both regulatory and proprietary interpretations of copyright law benefit from modding. Through critique of status quo solutions and analysis of a Microsoft exemplar this dissertation suggests a generic game content usage guide as an extra-legal, feasible solution that advances the goals of all parties involved without requiring legal intervention.
Assessments of Nanoparticle Procoagulant Properties in Blood
Creators: name: Jones, Clinton F.
Publisher: name: University of Utah
Year: 2014

description: The need for nanoparticle toxicity evaluations is well recognized as the number of applications for nanoparticles continues to grow. This dissertation seeks to reach beyond presently available assessments of nanoparticle-mediated toxicity and mortality to assess the consequences of intravenous nanoparticle injection upon the cellular and molecular participants in the hemostatic response. Based on published reports of severe in vivo coagulopathy, in vitro platelet aggregation and hemolysis for cationic poly(amido amine) (PAMAM) dendrimer nanoparticles, cationic generation-7 PAMAM dendrimers (G7-NH2) were hypothesized to possess strong and specific hemostatic properties and were utilized in the adaptation and development of assays evaluating nanoparticle procoagulant properties. The latter part of this dissertation utilizes the lipopolysaccharide (LPS)-sensitive limulus amoebocyte lysate (LAL) assay a surrogate to explore the hypothesis that intrinsically heightened nanoparticle properties of surface reactivity and specific surface area may disrupt endogenous biochemical cascades. The G7-NH2 were found to affect all key platelet functions, evidenced by severe morphological alteration, extensive aggregation and adhesion, release of alpha granule contents, and attenuation of thrombin generation. It was further demonstrated that extensive, direct, dendrimer-mediated aggregation of fibrinogen occurs via a thrombin-independent, electrostatic mechanism that also included G7-NH2 aggregation of bovine serum albumin and, by extension, the a majority of soluble plasma protein species due to their negative charge domains. Silica nanoparticles and two types of gold nanoparticles were demonstrated to increase the LAL assay response to LPS, while carboxy latex particles attenuated the LAL assay response. This apparent increase in the rate of production for the chromogenic LAL assay product for the gold and silica nanoparticles shows the potential for nanoparticles to exacerbate endogenous inflammatory responses to toxins co-presented in vivo. iv In summary, this dissertation demonstrates the potential for nanoparticle reactivity within or in concert with biological systems and specifically clarifies the mechanism of cationic dendrimer-induced hemostasis. Additionally, this work establishes additional models for the assessment of procoagulant properties of nanoparticles. The specific mechanistic findings presented herein represent an improvement upon the level of analysis usually performed for nanoparticles in the blood system and may guide rational design for safer nanoparticle-based, intravenous therapies.
Sonnenfleckenzeichnung Nr. 23416.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Development and application of micropatterned lipid bilayer arrays using fluorescence microscopy and sum-frequency vibrational imaging
Creators: name: Smith, Kathryn Alice
Publisher: name: University of Utah
Year: 2012

description: The importance of lipid bilayers to the structure and function of cellular membranes coupled with their inherent complexity has driven the development of analytical techniques capable of high-throughput investigation of these surfaces. This work describes a continuous flow microspotter (CFM) that was modified to create micropatterned lipid bilayer arrays (MLBAs). This dissertation is divided into four main parts, with the first chapter focusing on the characterization of MLBAs using fluorescence microscopy to ensure bilayer formation and integrity. The individually addressable nature of the CFM was also demonstrated using a multi-ligand array containing ganglioside GM1, dinitrophenyl (DNP) and biotin. A multiple protein-ligand assay was performed using the ligand array to detect three different fluorescently labeled proteins (cholera toxin b (CTb), anti-DNP antibody and NeutrAvidin) from solution simultaneously. The second part of this dissertation concentrates on creating stable MLBAs using a polymerizable lipid, poly(bis-SorbPC) in order to generate a more robust biosensing platform. The poly(lipid) arrays were compared directly to the MLBAs prepared without the polymerizable lipids using fluorescence microscopy to demonstrate their superior stability. A multiple protein-ligand assay was also performed to demonstrate the utility of these arrays and their potential application as a sensor substrate. iv Next, the MLBAs were used to investigate the impact of fifteen different lipid components on small molecule-membrane binding. The lipophilic dye merocyanine 540 (MC540) was used as a model small molecule and its binding was monitored by fluorescence microscopy. These studies demonstrate the potential of using MLBAs to investigate drug membrane interactions while preserving time and cost-effectiveness. Finally, sum-frequency vibrational imaging (SFVI) was developed to provide a surface specific noninvasive, analytical technique capable of monitoring lipid structure and dynamics in a high-throughput manner. The vibrational sensitivity of SFVI was investigated with an asymmetric lipid bilayer patterned by ultraviolet (UV) radiation lithographically. The phase behavior of three different binary mixtures in a MLBA was successfully investigated using SFVI. The SFVI setup had the sensitivity, resolution and field of view required for exploring lipid bilayer properties in an array format. This dissertation presents a new approach for assembling lipid bilayer arrays in combination with a powerful analytical technique to allow exploration of the physical properties of lipid membranes in a high-throughput and noninvasive manner.
Mechanical-tactile stimulation in a neonatal stress model alters depot-specific expression of proinflammatory cytokines, TNF-? and IL-6
Creators: name: Warner, Grace
Publisher: name: University of Utah
Year: 2012
Subjects: Mechanical-tactile stimulation
Neonatal stress
Premature infants
Proinflammatory cytokines

description: Premature infants are exposed to stressful events in the newborn intensive care unit (NICU). Neonatal stress is associated with increased adipose distribution to visceral depots (VAT). Adipose tissue, particularly VAT, produces two major cytokines associated with reducing insulin sensitivity, TNF-­?? and IL-­?6. Timed pregnant dams delivered at term (E21). Litters were culled to 10 pups (5 M, 5 F) and divided into three groups: control (CTL; maternal separation), neonatal stress (NS; maternal separation + injection + hypoxia/hyperoxia) and NS + MTS (10 min of stroking and limb movement). Treatments were given from D6-­?10 and tissue was harvested on D120. VAT and subcutaneous (SAT) depots measures were detected using MRI and DXA. Serum levels of insulin, TNF-­?? and IL-­?6 were measured with ELISA, and cytokine mRNA levels in VAT and SAT were measured by real-­?time PCR. Protein expression was determined through western blotting.
Sonnenfleckenzeichnung Nr. 23378.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Towards a Blockchain Contract-for-Difference Financial Instrument for Hedging Renewable Electricity Transactions
Creators: name: Olakunle Alao
name: Cuffe, Paul
Publisher: name: figshare
Year: 2020
Subjects: subject: 150201 Finance
subject: FOS: Economics and business

description: Presented at 2020 IEEE International Energy Conference (ENERGYCON)

Abstract:
Contract-for-Difference financial instruments are available to renewable electricity generators in day-ahead electricity markets to allow them to hedge against price and volume risk, together known as {\em revenue risk}. Traditional CfDs while designed to hedge revenue risk, introduce other new risks such as counterparty credit, margining and third-party risks. We therefore propose a novel financial instrument -- an Ethereum blockchain-based dual escrow smart contract, to serve as the mediator in a CfD agreement between a renewable electricity generator and supplier. This financial instrument addresses hedging related risks that result from traditional CfD agreements in day-ahead electricity markets. In this paper, we design the logic of the financial instrument, translate this logic to smart contract codes and demonstrate its expected performance. Overall, the proposed financial instrument has the benefits of reducing hedging related risks inherent in traditional CfDs. Likewise, it enables secure, efficient, cost-effective, consistent, reliable, transparent and frictionless transactions between contracting parties in a CfD agreement.
Sonnenfleckenzeichnung Nr. 23490.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.10.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Spectral complex conductivity inversion of airborne electromagnetic data
Creators: name: Goold, Jonathan W
Publisher: name: University of Utah
Year: 2012
Subjects: Prospecting
Induced polarization

description: The induced polarization (IP) phenomenon has been observed in numerous geologic structures, typically mineralized ore bodies. In polarizable structures a relationship exists between applied frequency and observed conductivity. In particular, conductivity can be observed to increase as applied frequency increases.  This relationship is readily identifiable in IP data; however, the relationship may be present in any frequency domain measurement. Additionally the relationship may be unique for different mineralized geologic structures and may provide information to identify the type of structure being surveyed.  The spectral IP method is a powerful tool for mineral exploration. Using the spectral IP method, variations in frequency-dependent complex conductivity, which correspond with different mineral targets, have been observed. Until recently, this method was applied as a ground based geophysical survey method only. However,  frequency-domain airborne electromagnetic (FDAEM) measurements may contain  information similar to that found in a ground-based IP survey, namely variations in  complex conductivity, i.e., conductivity with both real and imaginary value. In this  thesis, we examine the possibility of inverting for spectral resistivity in helicopter  electromagnetic data.  Our study is based both on forward modeling and inversion of synthetic FDAEM  data for models with both complex frequency-dependent conductivity and models  without. Comparison of electromagnetic synthetic data suggests a difference exists  between synthetic modeled data with frequency-dependent conductivity and  synthetic data with frequency-independent conductivity. Inversion of the synthetic  data suggests recovery of the frequency-dependent variations complex conductivity parameters in the synthetic models is possible. The differences in conductivity are  sensitive not only to the range of FDAEM measurements, but also to synthetic  ground-based measurements. A numerical modeling study demonstrates the possibility  of developing an airborne version of the spectral IP method.  The results of the synthetic model study suggest the technique of solving for complex conductivity within the inversion domain may be applied to field data.  In this thesis, we apply complex conductivity inversion to two different field collected  frequency domain helicopter electromagnetic (FDHEM) data sets. The data are collected over a kimberlite pipe and over an orogenic gold target. Both are conductive targets and therefore make excellent targets for conductivity inversion.  Variations in frequency-dependent complex conductivity behavior in both inversion  targets are observed. The inversion results for both targets suggest recovery  of frequency-dependent complex conductivity is possible in real, as opposed to  synthetic, data.  v
Ecosystem Responses to seasonal snowpack variation in the Western United States
Creators: name: Maurer, Gregory E.
Publisher: name: University of Utah
Year: 2014
Subjects: Carbon cycle
Climate
Ecohydrology
Snow hydrolog
Stable isotopes
Winter biogeochemistry

description: Snow cover directly influences soil temperature (Tsoil) and water content (θ), two primary drivers of ecosystem processes such as primary production and soil biogeochemical cycling. Variations in seasonal snowpack size, duration, and other characteristics therefore have the potential to significantly impact ecosystem structure and function. In the mountain ranges of the interior western United States, a region with abundant snowfall and complex topography, there is great temporal and spatial variability in snowpack characteristics. Interactions between snow and ecosystems are poorly quantified here, and with significant hydroclimatic (and snowpack) change occurring in the western U.S., it is increasingly critical to understand how this regional snowpack variability influences ecosystem structure and function. In three complementary research projects I tested the hypothesis that seasonal snowpack characteristics influence ecohydrological and biogeochemical processes in the montane ecosystems of this region. Using data from a large network of automated snowpack monitoring stations (252 sites), I quantified interannual and spatial patterns in Tsoil and θ, and their dependence on regional snowpack variation over an 11 year period. Below-snowpack and warm season Tsoil and θ were significantly related to snowpack size, melt date, and early season snow accumulation. In a 3-year manipulative experiment I compared the impacts of aeolian dust deposition, canopy structure, and interannual snowfall variability on snowpack ablation and ecosystem processes in a subalpine conifer forest. Canopy structure had a larger impact (through interception and shading) on snow accumulation and ablation than dust addition treatments. Dust and canopy structure effects on Tsoil, θ, and ecosystem processes were small compared to the effects of interannual variability in snowpack size and melt timing. In a study of 21 conifer forests in the Wasatch and Uinta ranges of Utah, I tested whether climatic drivers, including snowpack characteristics, explained spatial patterns in soil and detrital organic matter stock size and isotopic composition (13C and 15N). The climate of these sites explained only a small portion of variability in stock sizes and isotope ratios, suggesting that site-specific factors (disturbance, species, soil texture) are predominant controllers of the production and decomposition of forest organic matter stocks.
title: Community and commitment in the Church of England
Creators: name: Revell, Lynn
Publisher: name: University of Kent
Year: 2022

description: This thesis is a case study of two Church of England congregations in Kent. It describes and analyses the members’ understanding of their commitment to the church and the relationships forged within it. Members of the church congregations were found to be unwilling to participate in evangelism and were uncertain about sharing their commitment with either friends, family or a future generation. The most active core members of the church did not hold any shared religious or moral belief to be an essential aspect of their commitment to the church. Instead they celebrated diversity and difference within their own church and within the church more generally. The thesis examines the nature of the congregations’ religious commitment in the light of the decline of mainstream religion and the growth of New Age spirituality. It places the congregations’ understanding of community in the context both of the classical understanding of community and the contemporary debate between communitarianism and liberalism. The thesis argues that the members of the two congregations held in common a clear understanding of the importance of community. Moreover core members defined their community in terms of belonging rather than of a particular shared set of beliefs. The thesis concludes that although members use traditional language to describe the nature of their community, those communities have little in common with those imagined by classical sociology, and members’ commitment to the two churches could be characterised as an entirely contemporary expression of religiosity.
The Effect of strong, positive messages on personal transformation
Creators: name: Altschuler, Benjamin Joseph
Publisher: name: University of Utah
Year: 2012
Subjects: Life changes inventory
Peak-experience
Vivid information
Vividness

description: Mainstream tourism and recreation have long focused on two basic goals: customer satisfaction and economic viability. For most tourism and recreation providers, producing a satisfied customer leads to earning more money, allowing them to continue with their operations. Yet, there is a small, experimental, but growing part of the tourism industry that has begun to focus on different goals, mainly delightedness and personal transformation. Some of the most well known programs in this sector of tourism are study abroad programs, Birthright, and "voluntourism." Delightedness and personal transformation are strongly connected as indicated by Maslow?s concept of "peak-experiences." "Peak-experiences" are brief, unpredictable, and intense experiences that often produce important, long-lasting transformations within an individual. Without an experience producing delightedness within an individual, it is unlikely a "peak-experience" will occur.
Spinocerebellar ataxia with retinal degeneration: from phenotype to gene to protein.
Creators: name: Gouw, Launce G.
Publisher: name: University of Utah
Year: 2012
Subjects: DNA
Neuropathology

description: This dissertation describes a hereditary neurological disorder, autosomal dominant cerebellar ataxia with retinal degeneration, from initial clinical findings through analysis and isolation of the responsible gene, to study of the affected protein. The work described herein follows a research arc beginning with a patient presenting with worsening coordination and progressive blindness. A detailed clinicopathologic description of the signs, symptoms and autopsy findings occurring in affected related individuals ensued, creating strict criteria for the disease and establishing it as a distinct genetic entity. Subsequent linkage analysis allowed me to localize the gene responsible for the disease to chromosome 3p14-21.1. I named the disease spinocerebellar ataxia type 7 and the gene SCA7. I undertook experiments to isolate SCA7, which was eventually cloned. As I had hypothesized, SCA7 harbored a dynamic mutation due to an unstable region of DNA within the gene. This region, a trinucleotide repeat, is relatively short and stable in the general population, but expanded and unstable in affected individuals. I observed a direct correlation between repeat length and disease severity, and an inverse correlation with age-of-onset. I found allele instability and rate of disease transmission depended upon the sex of the parent transmitting the allele. The dissertation concludes with specific observations of SCA7's protein, ataxin-7. The SCA7 trinucleotide repeat generates a tract of glutamine amino acids within ataxin-7; I noted ataxin-7 had a nuclear distribution, forming subnuclear aggregates with a morphology that depended, in part, on glutamine tract length. My data infers ataxin-7s role in apoptosis, or programmed cell death. I demonstrated that ataxin-7 is specifically cleaved by caspase-7, an executioner of apoptosis. Furthermore, I noted longer glutamine tracts within ataxin-7 correlated with increased proapoptotic effects in cells expressing the protein. I modified ataxin-7 to confer caspase-7 cleavage resistance to prepare for further investigation into the protein's apoptotic role. The findings in this dissertation offer insights into the function and pathology of SCA7, the gene responsible for spinocerebellar ataxia with retinal degeneration. It is hoped that the information described in this manuscript may eventually lead to therapeutic modalities for what is currently an inexorable, often fatal disease.
The effect of body position upon pulmonary artery and pulmonary capillary wedge pressure in critically ill patients.
Creators: name: Burrage, Rebecca Lee
Publisher: name: University of Utah
Year: 2012
Subjects: Patients
Positioning
Blood Pressure

description: Critically ill subject, with a wide range of diagnoses and with pulmonary artery flow-directed balloon-tipped catheters in place, were studies to determine the effect of body position change on pulmonary artery and pulmonary capillary wedge pressure.  The head of the bed was raised from a supine flat position to 20 and 45 degrees, respectively.  The transducer was repositioned and zeroed at the phlebostatic level before each measurement was obtained.  Subjects were analyzed for pressure changes by four major approaches:  (1) The sample as a whole, (2) the sample divided according to presence and type of ventilatory support, (3) the sample divided according to degree of pulmonary artery mean pressure elevation in the supine flat position, and (4) the sample divided according to degree of pulmonary capillary wedge pressure elevation in the supine flat position.  Subjects with normal to mild elevation of pulmonary artery mean pressures in the supine flat position demonstrated a statistically significant change in pulmonary artery end-diastolic pressure (p < 0.03) when body position was adjusted from the 20 degree angle to the 45 degree angle of elevation.  No other statistically significant changes in pulmonary artery pressures were noted.  Relatively large standard deviations existed in many of the pressure differences.  The study finds that pulmonary artery pressures vary insignificantly when they are obtained in critically ill individuals with the head of the bed elevated.  Further study is recommended, however, before pressure are routinely obtained in a position other than he supine flat position.
Structure-function relationships of the Escherichia coli DnaJ molecular chaperone
Creators: name: Wall, Daniel Matthew
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Bacteria
subject: Genetics
subject: FOS: Biological sciences

description: This dissertation covers two separate research projects that are intellectually connected in that they both deal with studies on the heat shock response in Escherichia coli. The main project of this dissertation has focused on structure/function analysis of the DnaJ heat shock protein to help elucidate the molecular mechanisms by which the DnaJ and DnaK molecular chaperones function together. My results clearly show that the J-domain and G/F motif at the amino terminus of DnaJ interact with DnaK and regulate its function. Specifically, the J-domain stimulates the hydrolysis of ATP bound to DnaK and regulates DnaK's conformational state in an ATP-dependent fashion. In turn, the G/F motif is necessary to orchestrate effective substrate binding to DnaK, mediated by ATP hydrolysis. Hence both of these domains/modules of DnaJ are essential for DnaK's substrate binding activity in the presence of ATP. Thus, for at least some substrates, for example sigma32, DnaJ can catalytically activate" DnaK to form a stable complex, DnaK-sigma32. In addition, I have shown that this regulatory role of DnaJ is necessary and sufficient to elicit DnaJ chaperone function for lambda DNA replication and to negatively regulate the heat shock response.  The second project involved the characterization of an insertion mutation in the E. coli cydAB operon, which encodes cytochrome d, was isolated in a screen for new heat shock genes. Null alleles of the cydAB operon were found to exhibit very slow growth at elevated temperature, consistent with the finding that cydAB mRNA accumulates following a temperature upshift. Thus, cydAB is a heat shock operon. Interestingly, the cydAB operon was found to be under the novel heat shock regulation of the ArcA/ArcB two-component regulatory system. In related work, arcA and arcB null mutations were found as extragenic suppressers of cyd mutations. Most likely, such extragenic suppression of the Cyd defect is exerted through the derepression of cyo operon expression, which encodes an alternative cytochrome, o. Consistent with this interpretation, the cyo operon when cloned on a multicopy plasmid can suppress the various Cyd mutant phenotypes.
Relational query interface to the LDS Hospital patient database
Creators: name: Bennett, Douglas J.
Publisher: name: University of Utah
Year: 2012
Subjects: Patient Database
Optical Storage Media
Microcomputers
Software
Databases, Factual
Information Storage and Retrieval

description: Since 1970, the HELP hospital information system has been collecting data into a common integrated database at the LDS Hospital.  With the vast amount of stored information, there is a critical need for data extraction tools to use and verify these collected data.  The purpose of this thesis in to increase and improve the access to the HELP patient database so that physicians can utilize the wealth of stored information, in establishing new medical standards or verifying existing ones.  In order to increase the access to the patient database an information retrieval system will be created to acquire the data stored on the LDS Hospital TANDEM computer system and allow the transfer of that data to a variety of personal computers.  To improve access to the patient database, a new query interface of editor will generate and execute PAL (PTXT APPLICATION LANGUAGE) queries to extract information from the database.