cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis of precursor maltose-binding protein with proline in the + 1 position of the cleavage site interferes with the activity of Escherichia coli signal peptidase I in vivo
Creators: name: BARKOCY-GALLAGHER, G.
name: BASSFORD, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The residues occupying the -3 and -1 positions relative to the cleavage site of secretory precursor proteins are usually amino acids with small, neutral side chains that are thought to constitute the recognition site for the processing enzyme, signal peptidase. No restrictions have been established for residues positioned +1 to the cleavage site, although there have been several indications that mutant precursor proteins with a proline at +1 cannot be processed by Escherichia coli signal peptidase I (also called leader peptidase). A maltose-binding protein (MBP) species with proline at +1, designated MBP27-P, was translocated efficiently but not processed when expressed in E. coli cells. Unexpectedly, induced expression of MBP27-P was found to have an adverse effect on the processing kinetics of five different nonlipoprotein precursors analyzed, but not precursor Lpp (the major outer membrane lipoprotein) processed by a different enzyme, signal peptidase II. Cell growth also was inhibited following induction of MBP27-P synthesis. Substitutions in the MBP27-P signal peptide that blocked MBP translocation across the cytoplasmic membrane and, hence, access to the processing enzyme or that altered the signal peptidase I recognition site at position -1 restored both normal growth and processing of other precursors. Since overproduction of signal peptidase I also restored normal growth and processing to cells expressing unaltered MBP27-P, it was concluded that precursor MBP27-P interferes with the activity of the processing enzyme, probably by competing as a noncleavable substrate for the enzyme's active site. Thus, although signal peptidase I, like many other proteases, is unable to cleave an X-Pro bond, a proline at +1 does not prevent the enzyme from recognizing the normal processing site. When the RBP signal peptide was substituted for the MBP signal peptide of MBP27-P, the resultant hybrid protein was processed somewhat inefficiently at an alternate cleavage site and elicited a much reduced effect on cell growth and signal peptidase I activity. Although the MBP signal peptide also has an alternate cleavage site, the different properties of the RBP and MBP signal peptides with regard to the substitution of proline at +1 may be related to their respective secondary structures in the processing site region.
title: Liste des projets amorces 2013_2014
Creators: name: LabexMed
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: 2013_2014
description: date: Liste et résumés des projets amorces des ATRI 2013_2014
The 30 S lobster skeletal muscle Ca2+ release channel (ryanodine receptor) has functional properties distinct from the mammalian channel proteins.
Creators: name: Kramarcy, NR
name: Seok, JH
name: Sealock, R
name: Xu, Le
name: Meissner, G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (Chaps)-solubilized ryanodine receptor (RyR) of lobster skeletal muscle has been isolated by rate density centrifugation as a 30 S protein complex. Sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of the purified 30 S receptor revealed a single high molecular weight protein band with a mobility intermediate between those of the mammalian skeletal and cardiac M(r) 565,000 RyR polypeptides. Immunoblot analysis showed no or only minimal cross-reactivity with the rabbit skeletal and canine cardiac RyR polypeptides. By immunofluorescence the lobster RyR was localized to the junctions of the A-I bands. Following planar lipid bilayer reconstitution of the purified 30 S lobster RyR, single channel K+ and Ca2+ currents were observed which were modified by ryanodine and optimally activated by millimolar concentrations of cis (cytoplasmic) Ca2+. Vesicle-45Ca2+ flux measurements also indicated an optimal activation of the lobster Ca2+ channel by millimolar Ca2+, whereas 45Ca2+ efflux from mammalian skeletal and cardiac muscle sarcoplasmic reticulum (SR) vesicles is optimally activated by micromolar Ca2+. Further, mammalian muscle SR Ca2+ release activity is modulated by Mg2+ and ATP, whereas neither ligand appreciably affected 45Ca2+ efflux from lobster SR vesicles. These results suggested that lobster and mammalian muscle express immunologically and functionally distinct SR Ca2+ release channel protein complexes.
title: ADCO, Grènetier de Cîteaux : comptes (1499-1503) (11 H 1173), f. 00520
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1499-1503), Archives départementales de la Côte-d'Or, (11 H 1173), f. 00520, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Inhomogeneous Gaussian Free Field inside the interacting arctic curve
Creators: name: Granet, Etienne
name: Budzynski, Louise
name: Dubail, Jérôme
name: Jacobsen, Jesper Lykke
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The six-vertex model with domain-wall boundary conditions is one representative of a class of two-dimensional lattice statistical mechanics models that exhibit a phase separation known as the arctic curve phenomenon. In the thermodynamic limit, the degrees of freedom are completely frozen in a region near the boundary, while they are critically fluctuating in a central region. The arctic curve is the phase boundary that separates those two regions. Critical fluctuations inside the arctic curve have been studied extensively, both in physics and in mathematics, in free models (i.e., models that map to free fermions, or equivalently to determinantal point processes). Here we study those critical fluctuations in the interacting (i.e., not free, not determinantal) six-vertex model, and provide evidence for the following two claims: (i) the critical fluctuations are given by a Gaussian Free Field (GFF), as in the free case, but (ii) contrarily to the free case, the GFF is inhomogeneous, meaning that its coupling constant $K$ becomes position-dependent, $K \rightarrow K({\rm x})$. The evidence is mainly based on the numerical solution of appropriate Bethe ansatz equations with an imaginary extensive twist, and on transfer matrix computations, but the second claim is also supported by the analytic calculation of $K$ and its first two derivatives in selected points. Contrarily to the usual GFF, this inhomogeneous GFF is not defined in terms of the Green's function of the Laplacian $Δ= \nabla \cdot \nabla$ inside the critical domain, but instead, of the Green's function of a generalized Laplacian $Δ= \nabla \cdot \frac{1}{K} \nabla$ parametrized by the function $K$. Surprisingly, we also find that there is a change of regime when $Δ\leq -1/2$, with $K$ becoming singular at one point.
description: 27 pages, 13 figures
Relativistic mean-field description of light $Λ$ hypernuclei with large neutron excess
Creators: name: Vretenar, D.
name: Pöschl, W.
name: Lalazissis, G. A.
name: Ring, P.
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The Relativistic Hartree Bogoliubov model in coordinate space, with finite range pairing interaction, is applied to the description of $Λ$-hypernuclei with a large neutron excess. The addition of the $Λ$ hyperon to Ne isotopes with neutron halo can shift the neutron drip by stabilizing an otherwise unbound core nucleus. The additional binding of the halo neutrons to the core originates from the increase in magnitude of the spin-orbit term. Although the $Λ$ produces only a fractional change in the central mean-field potential, through a purely relativistic effect it increases the spin-orbit term which binds the outermost neutrons.
description: 8 pages, LATEX, 2 p.s. figures, submitted to Phys. Rev. C as a R.C
Pheidole dossena Wilson, 2003, new species
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole dossena

description: Pheidole dossena new species
Types Mus. Comp. Zool. Harvard.
etymology L dossena, clown, jester, referring to the odd head coloration.
diagnosis A member of the fallax group, similar to bergi in some traits, but easily distinguished from it and other group members as follows.
Major: brownish yellow with a conspicuous circular brown spot in center of vertex, and yellow appendages. Propodeal spines thin, one-third as long as the basal propodeal face and vertical to it; petiolar node very high, tapering in side view at the apex to form a blunt point; postpetiole from above elliptical, with subangulate lateral margins; rugoreticulum extending on each side of head from eye to antennal fossa; carinulae along midline reach from vertex to occiput, and flanked on occiput by short, feeble carinulae, with rest of posterior half of dorsal head surface smooth.
Minor: propodeal spines long and thin; occiput narrowed, with nuchal collar; carinulae cross border between mesopleuron and side of propodeum.
Measurements (mm) Holotype major. HW 1.14, HL 1.22, SL 0.64, EL 0.14, PW 0.56. Paratype minor: HW 0.52, HL 0.64, SL 0.68, EL 0.12, PW 0.34.
Color Major: body and mandibles light brownish yellow, verging to light brown in a circular spot in center of vertex; appendages clear yellow.
Minor: body brownish yellow, tending to clear yellow on mesosoma and waist, with a brownish tinge on head and gaster; appendages clear yellow.
Range I have seen material from numerous localities in lowland southern Mexico (Palenque, Chiapas), Belize, Guatemala, Honduras, Costa Rica, and Panama.
Biology Occurs on the floor of lowland forest, nesting in rotting wood.
figure Upper: holotype, major. Lower: paratype, minor. COSTA RICA: La Selva Biological Station, near Puerto Viejo, Heredia (Stefan Cover). Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 287
The B cell-specific nuclear factor OTF-2 positively regulates transcription of the human class II transplantation gene, DRA
Creators: name: Ting, J P
name: Itoh-Lindstrom, Y
name: Zeleznik-Le, N J
name: Clarke, J B
name: Moore, T L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The promoter of the major histocompatibility class II gene DRA contains an octamer element (ATTTGCAT) that is required for efficient DRA expression in B cells. Several DNA-binding proteins are known to bind this sequence. The best characterized are the B cell-specific OTF-2 and the ubiquitous OTF-1. This report directly demonstrates that OTF-2 but not OTF-1 regulates the DRA gene. In vitro transcription analysis using protein fractions enriched for the octamer-binding protein OTF-2 demonstrate a positive functional role for OTF-2 in DRA gene transcription. In contrast, OTF-1-enriched protein fractions did not affect DRA gene transcription although it functionally enhanced the transcription of another gene. Recombinant OTF-2 protein produced by in vitro transcription/translation could also enhance DRA gene transcription in vitro. In vivo transient transfection studies utilizing an OTF-2 expression vector resulted in similar findings: that OTF-2 protein enhanced DRA gene transcription, and that this effect requires an intact octamer element. Together these results constitute the first direct evidence of a positive role for the lymphoid-specific octamer-binding factor in DRA gene transcription.
The Origin of Cosmic Magnetic Fields
Creators: name: Tornkvist, Ola
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this talk, I review a number of particle-physics models that lead to the creation of magnetic fields in the early universe and address the complex problem of evolving such primordial magnetic fields into the fields observed today. Implications for future observations of the Cosmic Microwave Background (CMB) are discussed. Focussing on first-order phase transitions in the early universe, I describe how magnetic fields arise in the collision of expanding true-vacuum bubbles both in Abelian and non-Abelian gauge theories.
description: 9 pages, 1 figure, talk presented at the 3rd International Conference on Particle Physics and the Early Universe (COSMO-99), Trieste, Italy, 27 Sept - 3 Oct, 1999, to be published in the proceedings. Added references
Carnet nº 22, commencé à Haiphong (p. 1)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 9-8-1931
The effect of fibrin structure on fibrinolysis
Creators: name: GABRIEL, D.
name: MUGA, K
name: BOOTHROYD, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Fibrin structure contributes to the regulation of the fibrinolytic rate. As the fibrin fiber size is decreased, the fibrinolytic rate also decreases. Fibrin structure was altered by either changing the ratio of thrombin to fibrinogen, i.e. altering the assembly rate or by adding a fibrin assembly inhibitor, iopamidol. Changes in the fibrinolytic rate were followed by measuring the time dependence of the decrease in the fiber mass/length ratio during fibrinolysis. A measure of the overall fibrinolytic rate was determined from the decrease in the mass/length ratio versus time. An 8-fold reduction in the fibrinolytic rate was seen on decreasing the mass/length ratio from 2.7 x 10(12) daltons/cm to 0.5 x 10(12) daltons/cm. It is shown that thin fibrin fibers have a decreased rate of conversion of plasminogen to plasmin by tissue plasminogen activator and that thin fibrin fibers are lysed more slowly than thick fibrin fibers.
Pheidole durionei Wilson, 2003, new status
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole durionei

description: Pheidole durionei Santschi, new status
Pheidole wolfringi st. durionei Santschi 1923d: 51.
Types Naturhist. Mus. Basel.
Etymology Eponymous.
Diagnosis A member of the " jujuyensis complex" of the larger fallax group, comprising araneoides, cuevasi, durionei, jujuyensis, kugleri, leonina, leptina, lucretii, lupus, paraensis, punctithorax, tijucana, wallacei, and wolfringi. P. durionei is distinguished as follows.
Major: antennal scape exceeding occipital corner by 2X its own maximum width; carinulae on dorsal surface of head reaching almost all the way to the occiput, which is foveolate and opaque; rugoreticulum on head stretches on each side from eye to antennal fossa and anteriorly almost to the anterior border of the head; margins of pronotal dorsum foveolate; propodeal spines equilaterally triangular; postpetiole from above diamond-shaped, with angular lateral margins.
Minor: propodeal spines reduced to barely discernible denticles; region mesad to and forward from eyes foveolate; occiput narrowed, with nuchal collar.
Measurements (mm) Lectotype major: HW 1.20, HL 1.34, SL 1.22, EL 0.24, PW 0.60. Paralectotype minor: HW 0.52, HL 0.74, SL 1.08, EL 0.16, PW 0.40.
color Major: body and appendages light reddish brown except for gaster, which is plain medium brown. Minor: concolorous brownish yellow.
Range Known only from the type locality.
Biology Unknown.
figure Upper: lectotype, major. Lower: paralectotype, minor. ARGENTINA: Tanti Viejo, Cordoba. Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 288
The mitochondrial F1ATPase alpha-subunit is necessary for efficient import of mitochondrial precursors.
Creators: name: Yuan, H
name: Douglas, M G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The mitochondrial import and assembly of the F1ATPase subunits requires, respectively, the participation of the molecular chaperones hsp70SSA1 and hsp70SSC1 and other components operating on opposite sides of the mitochondrial membrane. In previous studies, both the homology and the assembly properties of the F1ATPase alpha-subunit (ATP1p) compared to the groEL homologue, hsp60, have led to the proposal that this subunit could exhibit chaperone-like activity. In this report the extent to which this subunit participates in protein transport has been determined by comparing import into mitochondria that lack the F1ATPase alpha-subunit (delta ATP1) versus mitochondria that lack the other major catalytic subunit, the F1ATPase beta-subunit (delta ATP2). Yeast mutants lacking the alpha-subunit but not the beta-subunit grow much more slowly than expected on fermentable carbon sources and exhibit delayed kinetics of protein import for several mitochondrial precursors such as the F1 beta subunit, hsp60MIF4 and subunits 4 and 5 of the cytochrome oxidase. In vitro and in vivo the F1 beta-subunit precursor accumulates as a translocation intermediate in absence of the F1 alpha-subunit. In the absence of both the ATPase subunits yeast grows at the same rate as a strain lacking only the beta-subunit, and import of mitochondrial precursors is restored to that of wild type. These data indicate that the F1 alpha-subunit likely functions as an "assembly partner" to influence protein import rather than functioning directly as a chaperone. These data are discussed in light of the relationship between the import and assembly of proteins in mitochondria.
Magnetotransport in phase-separated (Ga,Fe)N with $γ$'-Ga$_y$Fe$_{4-y}$N nanocrystals
Creators: name: Navarro-Quezada, A.
name: Aiglinger, M.
name: Faina, B.
name: Gas, K.
name: Matzer, M.
name: Li, Tian
name: Adhikari, R.
name: Sawicki, M.
name: Bonanni, A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The magnetotransport in phase-separated (Ga,Fe)N containing $γ$'-Ga$_y$Fe$_{4-y}$N (0\,$
description: 10 pages, 8 figures
Neutrinoless double beta decay in Supersymmetry with bilinear R-parity breaking
Creators: name: Hirsch, M.
name: Valle, J. W. F.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We reanalyze the contributions to neutrinoless double beta ($\znbb$) decay from supersymmetry with explicit breaking of R-parity. Although we keep both bilinear and trilinear terms, our emphasis is put on bilinear R-parity breaking terms, because these mimic more closely the models where the breaking of R-parity is spontaneous. Comparing the relevant Feynman diagrams we conclude that the usual mass mechanism of double beta decay is the dominant one. From the non-observation of $\znbb$ decay we set limits on the bilinear R-parity breaking parameters of typically a (few) 100 $keV$. Despite such stringent bounds, we stress that the magnitude of R-parity violating phenomena that can be expected at accelerator experiments can be very large, since they involve mainly the third generation, while $\znbb$ decay constrains only the first generation couplings.
description: revised after referee report, new figure 5, some typos corrected, accepted for publication in Nucl.Phys.B
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0204
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0204, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0204, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: abbaye de Cîteaux
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
Visualization of diagnostic heteroduplex DNAs from cystic fibrosis deletion heterozygotes provides an estimate of the kinking of DNA by bulged bases.
Creators: name: Barker, P
name: Wang, Y H
name: Griffith, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Previous studies (Hsieh, C.-H., and Griffith, J. D. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4833-4837) of DNAs containing extra or bulged bases on one of the two strands of a duplex showed that they exhibit slower electrophoretic mobility than non-bulged DNAs, indicating that bulges create stiff kinks in the DNA. Here we paired a 97-base single-stranded DNA from the intact cystic fibrosis (CF) gene with a complementary 94-base strand containing a central 3-base deletion (delta F508), common to many CF patients. This produced a 94-base pair DNA with a central 3-base bulge. Visualization of these DNAs by electron microscopy showed that twice as many bulge-containing DNAs had a central kink as compared with the non-bulged controls. Examination of the distribution of kinking angles showed that the bulged population contained 5-7-fold more molecules with a central kink of 80 +/- 10 degrees than did the control molecules. When the 3-base bulge was replaced by a 3-base gap, the resulting duplex DNA showed central kinks with a somewhat lower frequency but greater range of kinking angles.
Superconductivity from perturbative one-gluon exchange in high density quark matter
Creators: name: Schaefer, Thomas
name: Wilczek, Frank
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study color superconductivity in QCD at asymptotically large chemical potential. In this limit, pairing is dominated by perturbative one-gluon exchange. We derive the Eliashberg equation for the pairing gap and solve this equation numerically. Taking into account both magnetic and electric gluon exchanges, we find $Δ\sim g^{-5}\exp(-c/g)$ with $c=3π^2/\sqrt{2}$, verifying a recent result by Son. For chemical potentials that are of physical interest, $μ< 1$ GeV, the calculation ceases to be reliable quantitatively, but our results suggest that the gap can be as large as 100 MeV.
description: 19 pages, 6 figures. I accidentally replaced the paper with an outdated version. This version has typos corrected and will appear in PRD
Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily.
Creators: name: Cidlowski, JA
name: Allgood, Victoria E
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Recent studies have shown that vitamin B6 modulates transcriptional activation by the human glucocorticoid receptor in HeLa S3 cells. We have now examined the possibility that vitamin B6 might similarly influence transcriptional activation by the glucocorticoid receptor in other cell types, as well as gene expression mediated by other members of the steroid hormone receptor superfamily. We show that elevated vitamin B6 concentrations suppress by 40-65% the level of transcription mediated through the endogenous murine L cell glucocorticoid receptor, as well as the human receptor transfected into E8.2 and T47D cells. In contrast, glucocorticoid receptor-mediated transcription was enhanced 60-110% in mild vitamin deficiency. The level of hormone-independent constitutive gene expression was not affected by these same alterations in vitamin B6 concentration. These studies indicated that the transcriptional modulatory effects of the vitamin were neither restricted to specific cell types nor limited to the human form of the glucocorticoid receptor. We next determined if hormone-induced transcription by several other steroid receptors (androgen, progesterone, and estrogen receptors) was analogously affected by alterations in vitamin B6 concentration. Analysis of gene expression mediated through the mouse mammary tumor virus promoter revealed that transcriptional activation of both the androgen and progesterone receptors was reduced by 35-40% under conditions of elevated vitamin B6 and enhanced by 60-90% in deficiency, again under conditions where constitutive expression was unaffected. Using a different promoter, the estrogen-regulated vitellogenin promoter, we found that transcriptional activation of the estrogen receptor was similarly affected. Estrogen-induced gene expression was reduced by 30% under conditions of elevated intracellular vitamin B6 and enhanced by 85% in vitamin deficiency. Thus, vitamin B6 modulates transcriptional activation by multiple classes of steroid hormone receptors. The similarities in vitamin B6 effects on transcription mediated through different promoters, the mouse mammary tumor virus and vitellogenin promoters, suggest that this vitamin may modulate the expression of a diverse array of hormonally responsive genes. These observations together support the hypothesis that vitamin B6 represents a physiological modulator of steroid hormone action.
Pheidole eidmanni Menozzi
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole eidmanni

description: Pheidole eidmanni Menozzi
Pheidole eidmanni Menozzi 1926c: 69.
Types Institute di Entomologia "Guido Grandi."
Etymology Named after the entomologist H. Eidmann.
Diagnosis A member of the fallax group, similar in different characters to bergi, cordiceps, nitidula, and pampana, and especially so with nitidula, with which it may be synonymous, and distinguished as follows.
Major: concavity of occipital border very broad in frontal view; rugoreticulum less extensive on genae (than in nitidula); in dorsaloblique view, humerus lower than convexity that follows it; pronotum completely smooth and shiny. Measurements (mm) Lectotype major: HW 1.06, HL 1.08, SL 0.64, EL 0.20, PW 0.56. Color Major: body concolorous medium reddish brown.
Range Known only from the type locality.
Biology Unknown.
Figure Lectotype, major. BRAZIL: Mogidas-Cruzes, Sao Paulo. Scale bar = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 289
Relativistic transport theory of N, Δand N^{*}(1440) interacting through $σ$, $ω$ and $π$ mesons
Creators: name: Mao, Guangjun
name: Neise, L.
name: Stöcker, H.
name: Li, W. Greiner Zhuxia
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A self-consistent relativistic integral-differential equation of the Boltzmann-Uehling-Uhlenbeck-type for the $N^{*}$(1440) resonance is developed based on an effective Lagrangian of baryons interacting through mesons. The closed time-path Green's function technique and semi-classical, quasi-particle and Born approximations are employed in the derivation. The non-equilibrium RBUU-type equation for the $N^{*}$(1440) is consistent with that of nucleon's and delta's which we derived before. Thus, we obtain a set of coupled equations for the $N$, $Δ$ and $N^{*}$(1440) distribution functions. All the $N^{*}$(1440)-relevant in-medium two-body scattering cross sections within the $N$, $Δ$ and $N^{*}$(1440) system are derived from the same effective Lagrangian in addition to the mean field and presented analytically, which can be directly used in the study of relativistic heavy-ion collisions. The theoretical prediction of the free $pp \to pp^{*}(1440)$ cross section is in good agreement with the experimental data. We calculate the in-medium $N + N \to N + N^{*}$, $N^{*} + N \to N + N$ and $N^{*} + N \to N^{*} + N$ cross sections in cold nuclear matter up to twice the nuclear matter density. The influence of different choices of the $N^{*}N^{*}$ coupling strengths, which can not be obtained through fitting certain experimental data, are discussed. The results show that the density dependence of predicted in-medium cross sections are sensitive to the $N^{*}N^{*}$ coupling strengths used. An evident density dependence will appear when a large scalar coupling strength of $g_{N^{*}N^{*}}^σ$ is assumed.
description: 64 pages, Latex, 13 PostScript figures included
$\bar{K}\bar{D} N$ molecular state as a "$u u d s \bar{c}$ pentaquark" in a three-body calculation
Creators: name: Yamagata-Sekihara, Junko
name: Sekihara, Takayasu
Publisher: name: arXiv
Year: 2018
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We predict a new three-body hadronic molecule composed of antikaon $\bar{K}$, anticharm meson $\bar{D}$, and nucleon $N$ with spin/parity $J^{P} = 1/2^{+}$ and isospin $I = 1/2$. This state behaves like an explicit pentaquark state because its minimal quark configuration is $u u d s \bar{c}$ or $u d d s \bar{c}$. Owing to the attraction between every pair of two hadrons, in particular the $\bar{K}\bar{D}$ attraction which dynamically generates $D_{s 0} (2317)^{-}$ and $\bar{K} N$ attraction which dynamically generates $Λ(1405)$, the $\bar{K}\bar{D} N$ system is bound, and its eigenenergy is calculated as $3244 - 17 i$ MeV in a nonrelativistic three-body potential model. We discuss properties of this $\bar{K} \bar{D} N$ quasibound state which emerge uniquely in three-body dynamics.
description: 12 pages, 5 figures
A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: The androgen-regulated 20-kDa protein gene consists of four exons that code for a major secretory protein of rat ventral prostate. Analysis of its potential cis-acting transcriptional regulatory elements revealed that a large intron 1 region (In-1) had stronger androgen response element (ARE) activity than did the 5'-flanking DNA. In cotransfected CV1 cells, In-1 and its most active subfragment In-1c functioned as AREs but not glucocorticoid response elements (GRE). Nevertheless several ARE/GRE-like partial palindromic sequences are present in In-1c, and it bound both androgen receptors and glucocorticoid receptors in mobility shift assays. A cluster of three ARE/GRE-like sequences contained within a 39-base pair sequence of In-1c had both ARE and GRE activities when analyzed as an isolated oligonucleotide, suggesting that other elements within In-1c determined its ARE specificity. In addition to ARE/GRE-like sequences, In-1c contains putative response elements for the transcription factors AP1, CREB, AP2, OCT-1, C/EBP, and a number of inverted and direct repeats. The ARE specificity of In-1c observed in CV1 cells was diminished in PC3 and HeLa cells transiently cotransfected with an androgen receptor or glucocorticoid receptor expression vector together with an In-1c reporter vector; however, the ARE activity of In-1c was greater than its GRE activity in these cell lines. Interestingly, a 131-base pair subfragment of In-1c retained ARE specificity in all three cell lines.
Cosmology of One Extra Dimension with Localized Gravity
Creators: name: Csaki, Csaba
name: Graesser, Michael
name: Kolda, Christopher
name: Terning, John
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine the cosmology of the two recently proposed scenarios for a five dimensional universe with localized gravity. We find that the scenario with a non-compact fifth dimension is potentially viable, while the scenario which might solve the hierarchy problem predicts a contracting universe, leading to a variety of cosmological problems.
description: 10 pages, LaTeX. Reference added
Topological quantum phase transition in magnetic topological insulator upon magnetization rotation
Creators: name: Kawamura, Minoru
name: Mogi, Masataka
name: Yoshimi, Ryutaro
name: Tsukazaki, Atsushi
name: Kozuka, Yusuke
name: Takahashi, Kei. S.
name: Kawasaki, Masashi
name: Tokura, Yoshinori
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report a continuous phase transition between quantum-anomalous-Hall and trivial-insulator phases in a magnetic topological insulator upon magnetization rotation. The Hall conductivity transits from one plateau of quantized Hall conductivity $e^2/h$ to the other plateau of zero Hall conductivity. The transition curves taken at various temperatures cross almost at a single point, exemplifying the critical behavior of the transition. The slope of the transition curves follows a power-law temperature dependence with a critical exponent of $-0.61$. This suggests a common underlying origin in the plateau transitions between the QAH and quantum Hall systems, which is a percolation of one-dimensional chiral edge channels.
description: 3 figures
ХУДОЖЕСТВЕННОЕ И ВОСПИТАТЕЛЬНОЕ ЗНАЧЕНИЕ ВОКАЛЬНОГО ЭСТРАДНОГО АНСАМБЛЯ
Creators: name: Рахмонова, Шахноза
Publisher: name: Zenodo
Year: 2024

description: В данной статье рассматриваются особенности и специфика работы с вокальным ансамблем. Рассматриваются вокальные особенности детского голоса, а также вокальные особенности голоса в подростковом возрасте, методики работы над музыкальным произведением с учетом возрастных особенностей и индивидуальных способностей исполняющего, основные этапы разучивания произведения.
A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation
Creators: name: CLEMMONS, D.
name: BUSBY, W.
name: JONES, S.
name: ROTWEIN, P
name: JAMES, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Insulin-like growth factor-binding proteins (IGFBPs) are a family of secreted proteins that bind insulin-like growth factors I and II (IGFs I and II) and are capable of modulating IGF actions on target cells. We have shown previously that C2 myoblasts secrete a single approximately 29-kDa IGFBP during their terminal differentiation (Tollefsen, S. E., Lajara, R., McCusker, R. H., Clemmons, D. R., and Rotwein, P. (1989) J. Biol. Chem. 264, 13810-13817). In this study, we have purified the protein from C2 cell-conditioned media by conventional and IGF-affinity chromatography, cloned its cDNA by PCR-based and traditional library screening, and identified it as mouse IGFBP-5. The resultant 5561 nucleotide cDNA encodes a 252-amino acid mature protein (predicted M(r) approximately 28,400) that is 97% identical to rat and human IGFBP-5. In differentiating C2 myoblasts and in F3 azamyoblasts the > 6-kilobase IGFBP-5 mRNA accumulates concomitantly with induction of myogen mRNA, an early marker of muscle differentiation. Ligand blot analysis shows that IGFBP-5 protein is secreted within 12 h of the onset of differentiation in these cells and that it is the only IGFBP produced in several fusing skeletal muscle cell lines. In vivo, IGFBP-5 transcripts are expressed in a variety of mouse tissues including striated muscle, but, unlike other IGFBPs, it is barely detectable in liver. IGFBP-5 is more conserved than other IGFBPs in mammals; its conserved structure and sequence also extends to non-mammalian vertebrates. Hybridization of a mouse BP5 coding region probe to RNA from several chicken and Xenopus tissues demonstrated similarly sized transcripts in these species. A partial Xenopus cDNA is identical in 38/45 deduced amino acids to the mammalian proteins. Identification of an IGF-binding protein that is produced during myoblast differentiation provides a model system in which to study the potential modulatory role of IGFBPs in development.
Extracting Sentiment Attitudes From Analytical Texts
Creators: name: Loukachevitch, Natalia
name: Rusnachenko, Nicolay
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: In this paper we present the RuSentRel corpus including analytical texts in the sphere of international relations. For each document we annotated sentiments from the author to mentioned named entities, and sentiments of relations between mentioned entities. In the current experiments, we considered the problem of extracting sentiment relations between entities for the whole documents as a three-class machine learning task. We experimented with conventional machine-learning methods (Naive Bayes, SVM, Random Forest).
Pheidole fallax Mayr
Creators: name: Wilson, E. O.
Publisher: name: Harvard University Press
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole fallax

description: Pheidole fallax Mayr
Pheidole fallax Mayr 1870b: 984. Syn.: Pheidole fallax r. columbica Forel 1886b: xliv, n. syn.; Pheidole jelskii var. fallacior Forel 1901j: 356, n. syn.; Pheidole fallax var. britoi Forel 1912g: 221, n. syn.; Pheidole fallax var. ovalis Forel 1912g: 221, n. syn. Raised to species level in this monograph: infraspecific variants jelskii, obscurithorax, puttemansi.
Types Naturhist. Mus. Wien.
Etymology L fallax, deceitful, false; allusion unknown.
diagnosis A member of the fallax group, similar to gigas, jelskii, obscurithorax, puttemansi, roushae, tobini, and valens, and especially the very abundant and widespread jelskii, with which it is easily confused.
Major: posterior half of dorsal surface of head primarily carinulate, with rugoreticulum extensive mesad of the eye most of the way to the occiput; pronotum transversely carinulate; anterior fourth to third of central strip of first gastral tergite shagreened; head tapered toward occiput in side view, as shown.
P. fallax differs from P. jelskii as follows and as depicted: in major, petiolar node higher and descending to peduncle by a much more concave curve, and scapes shorter (Scape Length/Head Width 0.50-0.59 as opposed to 0.60-0.70 in jelskii major); and in minor, occiput much broader and nuchal collar thinner than in jelskii.
Measurements (mm) Lectotype major: HW 1.72, HL 1.84, SL 0.90, EL 0.24, PW 0.80. Paralectotype minor: HW 0.60, HL 0.72, SL 0.92, EL 0.18, PW 0.40.
Color Major and minor: body medium reddish brown, with gaster sometimes dark reddish brown.
Range A circum-Caribbean species, which I have verified from the Greater Antilles (Cuba, Jamaica, Puerto Rico), Central America, Colombia, and Venezuela. No certain records exist from the Lesser Antilles, where the closely related jelskii abounds.
Biology Because fallax has a range enclosed by the more abundant jelskii and is so easily confused with it, natural history notes published in the past under the name of either species are generally unreliable.
Figure Upper: major (compared with lectotype); variation in hypostomal teeth shown is with specimens from Puerto Rico (4 teeth) and Cuba (3 teeth). Lower: minor (compared with paralectotype, which shares the long, thin propodeal spine depicted; the very short spine at the top is of a Panama specimen, and the medium-length spine in the middle is of a syntype of the synonymous " var. columbica "). CUBA: Soledad, Las Villas. (Type locality: Cuba.) Scale bars = 1 mm.
description: Published as part of Wilson, E. O., 2003, Pheidole in the New World. A dominant, hyperdiverse ant genus., Cambridge, MA :Harvard University Press on page 290
New approximate solutions of the Ginsparg-Wilson equation - tests in 2-d
Creators: name: Gattringer, Christof
name: Hip, Ivan
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A new method for finding approximate solutions of the Ginsparg-Wilson equation is tested in 2-d. The Dirac operator is first constructed and then used in a dynamical simulation of the 2-flavor Schwinger model. We find a very small mass of the pi-particle implying almost chirally symmetric fermions. The generalization of our method to 4-d is straightforward.
description: Revised version (to appear in Physics Letters B); references added and regrouped; new comment on finite size effects
About BIRDS project (Bioinformatics and Information Retrieval Data Structures Analysis and Design)
Creators: name: de Bernardo, Guillermo
name: Ladra, Susana
Publisher: name: arXiv
Year: 2018
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: 68

description: BIRDS stands for "Bioinformatics and Information Retrieval Data Structures analysis and design" and is a 4-year project (2016--2019) that has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 690941. The overall goal of BIRDS is to establish a long term international network involving leading researchers in the development of efficient data structures in the fields of Bioinformatics and Information Retrieval, to strengthen the partnership through the exchange of knowledge and expertise, and to develop integrated approaches to improve current approaches in both fields. The research will address challenges in storing, processing, indexing, searching and navigating genome-scale data by designing new algorithms and data structures for sequence analysis, networks representation or compressing and indexing repetitive data. BIRDS project is carried out by 7 research institutions from Australia (University of Melbourne), Chile (University of Chile and University of Concepción), Finland (University of Helsinki), Japan (Kyushu University), Portugal (Instituto de Engenharia de Sistemas e Computadores, Investigação e Desenvolvimento em Lisboa, INESC-ID), and Spain (University of A Coruña), and a Spanish SME (Enxenio S.L.). It is coordinated by the University of A Coruña (Spain).
description: This research has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Actions H2020-MSCA-RISE-2015 BIRDS GA No. 690941. CERI 2018
Variable Nature of Magnetically-Driven Ultra-Fast Outflows
Creators: name: Fukumura, Keigo
name: Kazanas, Demosthenes
name: Shrader, Chris
name: Behar, Ehud
name: Tombesi, Francesco
name: Contopoulos, Ioannis
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Among a number of active galactic nuclei (AGNs) that drive ionized outflows in X-rays, a low-redshift (z = 0.184) quasar, PDS 456, is long known to exhibit one of the exemplary ultra-fast outflows (UFOs). However, the physical process of acceleration mechanism is yet to be definitively constrained. In this work, we model the variations of the Fe K UFO properties in PDS 456 over many epochs in X-ray observations in the context of magnetohydrodynamic (MHD) accretion-disk winds employed in our earlier studies of similar X-ray absorbers. We applied the model to the 2013/2014 XMM-Newton/NuSTAR spectra to determine the UFO's condition; namely, velocity, ionization parameter, column density and equivalent width (EW). Under some provisions on the dependence of X-ray luminosity on the accretion rate applicable to near-Eddington state, our photoionization calculations, coupled to a 2.5-dimensional MHD-driven wind model, can further reproduce the observed correlations of the UFO velocity and the anti-correlation of its EW with X-ray strength of PDS 456. This work demonstrates that UFOs, even without radiative pressure, can be driven as an extreme case purely by magnetic interaction while also producing the observed spectrum and correlations.
description: accepted to ApJ Letter; 16 pages, 3 figures