Metadata supporting the article: Adolescent alcohol, nuts and fiber: combined effects on benign breast disease risk in young women
Creators: name: Berkey, Catherine S.
name: Rulla M. Tamimi
name: Willett, Walter C.
name: Rosner, Bernard
name: Hickey, Martha
name: Adetunji T. Toriola
name: A. Lindsay Frazier
name: Colditz, Graham A.
Publisher: name: figshare
Year: 2020
Subjects: subject: Cancer
subject: 111712 Health Promotion
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine

description: In this study, the authors have investigated the combined effect of alcohol and nut/peanut butter consumption (and, separately, total dietary fiber), by girls aged 14- 17yr (in high school 1996-2001), on risk of biopsy-confirmed benign breast disease (BBD) in young women.<b><br></b><b>Data access: </b>The data that support the findings of this study are not publicly available, but can be made available to researchers on reasonable request. External investigators who are interested in collaborating and using the cohort data, are invited to fill out a form that asks about the details of the collaboration. Please visit <b>http://nhs2survey.org/gutswordpress/index.php/researchers/information-for-researchers/</b> for more information on data access. External collaborators (after being granted permission), will be provided a login and password to get access to the data, the Channing computing system and detailed documentation and training materials for where to find data, what analytic tools are available and examples of analyses.<br><b>Study approval and patient consent</b>: The study was approved by the Institutional Review Board at Brigham and Women’s Hospital, Boston. Mothers provided informed consent, and their 9-15year old daughters assented by completing baseline questionnaires in 1996.<br><b>Study aims and methodology</b>: Adolescent drinking is associated with higher risks of proliferative BBD and invasive breast cancer (BC). Furthermore, adolescent nut and fiber consumptions are associated with lower risks of benign lesions and premenopausal BC. The authors hypothesized that diet (nuts, fiber) may mitigate the elevated BBD risk associated with alcohol.The Growing Up Today Study (founding PI, Dr. Colditz) includes 9031 girls from all 50 states who are daughters of NHSII participants. A prospective cohort of 9031 females, 9-15yr at baseline, completed questionnaires in 1996, 1997, 1998, 1999, 2000, 2001, 2003, 2005, 2007, 2010, 2013 and 2014. Participants completed food frequency questionnaires between 1996 and 2001. In 2005, participants (18yr+) began reporting biopsy-confirmed BBD (N=173 cases). Multivariable logistic regression estimated associations between BBD and cross classified intakes (14-17yr) of alcohol and peanut butter/nuts (separately, total dietary fiber). For more details on the methodology, please read the related article.<br><b>Data supporting the tables in the published article</b>: The dataset supporting tables 1-3, is <b>bbd2005_2014.sas7bdat</b>, and it is in <b>SAS file format.</b><br><b>Software needed to access data</b>: The SAS statistical software is needed to access the datasets listed above.<br>