cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cognitive biases and functional brain networks underlying delusions in schizophrenia
Creators: name: Lavigne, Katie M.
Publisher: name: University of British Columbia
Year: 2018

description: Integrating evidence that contradicts a belief is a fundamental aspect of belief revision and is closely linked to delusions in schizophrenia. In this research, we examined the cognitive and brain mechanisms underlying disconfirmatory evidence integration, their relation to delusions and the bias against disconfirmatory evidence (BADE) in schizophrenia, as well as associations between changes in delusion severity, BADE, and functional brain activity related to evidence integration. Across three neuroimaging studies, two functional brain networks emerged as central to disconfirmatory evidence integration: a visual attention network (VsAN) including dorsal anterior cingulate cortex and bilateral insula; and a cognitive evaluation network (CEN) involving rostrolateral/orbitofrontal cortex, inferior frontal gyrus, and inferior parietal lobule. In study 1, these networks showed sequential activation and increased activity during disconfirmatory evidence integration, suggesting they were involved in distinct evidence detection and integration processes. In study 2, we found that activity in these networks was differentially associated with delusions, with delusional schizophrenia patients showing VsAN hyperactivity and CEN hypoactivity relative to controls. Subsequent analyses examining associations between activity in these networks and behaviour revealed that BADE was positively associated with VsAN activity during confirmatory evidence integration, and negatively associated with CEN activity during disconfirmatory evidence integration. These findings indicate that VsAN hyperactivity underlies the focus on confirmatory evidence, and CEN hypoactivity the avoidance of disconfirmatory evidence, that contributes to impaired evidence integration and delusion maintenance in schizophrenia. Finally, in study 3, we demonstrated that poorer evidence integration over time was related to greater hyperactivity in the VsAN and hypoactivity in the CEN, from time 1 to time 2, and that improved positive symptoms (including delusions) were associated with normalization of activity in the CEN, showing that activity in these networks fluctuates as a function of changes in behavioural BADE evidence integration and symptoms. This research represents the first comprehensive study of the cognitive and brain mechanisms underlying disconfirmatory evidence integration and behavioural BADE in schizophrenia patients with delusions, and highlights brain networks underlying cognitive biases related to important aspects of delusion maintenance in schizophrenia: the focus on confirmatory evidence; and the avoidance of disconfirmatory evidence.
A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors
Creators: name: Llanos, Manuel A.
name: Sbaraglini, María L.
name: Villalba, María L.
name: Ruiz, María D.
name: Carrillo, Carolina
name: Soto, Catalina Alba
name: Talevi, Alan
name: Angeli, Andrea
name: Parkkila, Seppo
name: Supuran, Claudiu T.
name: Gavernet, Luciana
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel and selective TcCA inhibitors. The combination of properly validated computational methodologies such as comparative modelling, molecular dynamics and docking simulations allowed us to find high potency hits, with KI values in the nanomolar range. The compounds also showed trypanocidal effects against T. cruzi epimastigotes and trypomastigotes. All the candidates are selective for inhibiting TcCA over the human isoform CA II, which is encouraging in terms of possible therapeutic safety and efficacy.
Supplementary Information of Fully Textile Interdigitated Capacitive Strain Sensors for Monitoring Yoga Movements
Creators: name: Papaefstathiou, Maria
name: menon, carlo
name: Elgendi, Mohamed
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 329999
subject: Other biomedical and clinical sciences not elsewhere classified
classificationCode: 400303
subject: Biomechanical engineering
classificationCode: 400906
subject: Electronic sensors
classificationCode: 420799
subject: Sports science and exercise not elsewhere classified

description: In this Supplementary Information, all the additional information that may needed.
Between the conjectures of Pólya and Turán
Creators: name: Trudgian, T. S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: This paper is concerned with the constancy in the sign of $L(X, α) = \sum_{1}^{X} \frac{λ(n)}{n^α}$, where $λ(n)$ the Liouville function. The non-positivity of $L(X, 0)$ is the Pólya conjecture, and the non-negativity of $L(X, 1)$ is the Turán conjecture --- both of which are false. By constructing an auxiliary function, evidence is provided that $L(X, \frac{1}{2})$ is the best contender for constancy in sign. The core of this paper is the conjecture that $L(X, \frac{1}{2}) \leq 0$ for all $X\geq 17$: this has been verified for $X\leq 300,001$.
description: 5 pages
Increasing culturability of plant microbiome towards core microbiome manipulation and engineering
Creators: name: Sarhan, Mohamed Sabry Mohamed
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 570 Life science
subject: 580 Botanical sciences
subject: 630 Agriculture

description: This study aimed to optimize the use of plant-based culture media for exploration of the plant-associated microbiota and extend the culturability borders to isolate novel bacterial taxa and meticulously characterize the culture-dependent and culture-independent microbiomes in view of the developed plant-based culture media. Throughout the study, we could prove that plant-based culture media are able to support the recovery of previously uncultured plant-associated bacteria, and also support the enrichment of bacterial lineages that belong to the candidate phyla radiation (CPR).
Asteroid Retrieval Technology Development From the Asteroid Return Mission Study
Creators: name: Dimotakis, Paul E.
name: Prince, Thomas A.
name: Brophy, John R.
name: Friedman, Louis
Publisher: name: Keck Institute for Space Studies
Year: 2018

description: The Keck Institute for Space Studies (KISS) workshops on the Asteroid Return Mission concept explored and established the feasibility of capturing and returning an entire near-Earth asteroid (NEA) to lunar orbit by the middle of the next decade, and identified the benefits that such an endeavor would provide to NASA, the
nation, and the world. The goal of this technology development program was to start the process of working select technical issues identified in the study to significantly enhance the prospects of making the asteroid capture and return mission a reality.

Key areas of accomplishment:

A) Mission architecture definition:
1. Trajectory design
2. SEP propulsion technology
3. Mission/System Design
4. Solar Thermal Power & Propulsion Technology Introduction
- Study beam-forming deployable reflector designs for
solar concentrators.
- Monitor progress in solar-electric power production
technologies.

B) Small Near Earth Asteroid (NEA) detection:
1. Modifications to the search/detection software employed in the Palomar Transient Factory (PTF).
2. Demonstration of the upgraded PTF as a useful tool for
detecting small NEAs.

C) In-Situ Resource Utilization (ISRU) for asteroids, specifically for power and propulsion.
Ultraviolet-shielding and water resistance properties of graphene quantum dots/ polyvinyl alcohol composite-based film
Creators: name: Sutthipoj Wongrerkdee
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Graphene quantum dots
UV?shielding
Optical transmittance
UV absorption
Water resistance

description: Journal of Metals, Materials and Minerals, 30, 4, 90-96
Untersuchungen zum Vorkommen von Microthrix parvicella in SBR-Anlagen
Creators: name: Mallouhi, Lana
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 624 Structural and Environmental Engineering

description: Die vorliegende Arbeit befasst sich mit dem Vorkommen von Microthrix parvicella in SBR-Anlagen. SBR-Anlagen bieten eine gute Umgebung für das Wachstum von M. parvicella. Untersuchungen über den Einfluss der sehr geringen Belastung < 0,05 kg BSB5/(kg TS∙d) sind bisher nur in begrenzter Anzahl vorhanden. Deswegen werden im Rahmen dieser Arbeit 13 SBR-Anlagen, davon einige mit simultaner aerober Schlammstabilisierung, in Deutschland mikroskopisch untersucht, um Microthrix parvicella zu bestimmen. Der Einfluss der Vorfällung mit AlCl3 auf das Wachstum von M. parvicella wurde auch ermittelt.
Spherically symmetric solutions to a model for phase transitions driven by configurational forces
Creators: name: Ou, Yaobin
name: Zhu, Peicheng
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 35K55, 74E15

description: We prove the global in time existence of spherically symmetric solutions to an initial-boundary value problem for a system of partial differential equations, which consists of the equations of linear elasticity and a nonlinear, non-uniformly parabolic equation of second order. The problem models the behavior in time of materials in which martensitic phase transitions, driven by configurational forces, take place, and can be considered to be a regularization of the corresponding sharp interface model. By assuming that the solutions are spherically symmetric, we reduce the original multidimensional problem to the one in one space dimension, then prove the existence of spherically symmetric solutions. Our proof is valid due to the essential feature that the reduced problem is one space dimensional.
description: 25 pages
Characterization and In-situ Monitoring of Sub-stoichiometric Adjustable T_c Titanium Nitride Growth
Creators: name: Vissers, Michael R.
name: Gao, Jiansong
name: Kline, Jeffrey S.
name: Sandberg, Martin
name: Weides, Martin P.
name: Wisbey, David S.
name: Pappas, David P.
Publisher: name: Keck Institute for Space Studies
Year: 2012

description: The structural and electrical properties of Ti-N films deposited by reactive sputtering depend on their growth parameters, in particular the Ar:N_2 gas ratio. We show that the nitrogen percentage changes the crystallographic phase of the film progressively from pure α-Ti, through an α-Ti phase with interstitial nitrogen, to stoichiometric Ti_2N, and through a substoichiometric TiN_X to stoichiometric TiN. These changes also affect the superconducting transition temperature, T_c, allowing, the superconducting properties to be tailored for specific applications. After decreasing from a T_c of 0.4 K for pure Ti down to below 50 mK at the Ti_2N point, the T_c then increases rapidly up to nearly 5 K over a narrow range of nitrogen incorporation. This very sharp increase of T_c makes it difficult to control the properties of the film from wafer-to-wafer as well as across a given wafer to within acceptable margins for device fabrication. Here we show that the nitrogen composition and hence the superconductive properties are related to, and can be determined by, spectroscopic ellipsometry. Therefore, this technique may be used for process control and wafer screening prior to investing time in processing devices.
Charmonium-nucleon interaction from lattice QCD with a relativistic heavy quark action
Creators: name: Kawanai, Taichi
name: Sasaki, Shoichi
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Detailed information of the low-energy interaction between the charmonia (ηc and J/ψ) and the nucleon is indispensable for exploring the formation of charmonium bound to nuclei. In order to investigate the charmonium-nucleon interactions at low energies, we adopt two essentially different approaches in lattice QCD simulations. The charmonium-nucleon potential can be calculated from the equal-time Bethe-Salpeter amplitude through the effective Schrödinger equation. This novel method is based on the same idea originally applied for the nucleon force by Aoki- Hatsuda-Ishii. Another approach is to utilize extended Lüscher's formula with partially twisted boundary conditions, which allows us to calculate the s-wave phase shift at any small value of the relative momentum even in a finite box. We then extract model independent information of the scattering length and the effective range from the phase shift through the effective-range expansion. Our simulations are carried out at a lattice cutoff of $1/a \approx$ 2 GeV in a spatial volume of (3 fm)^3 with the non-perturbatively O(a)-improved Wilson fermions for the light quarks and a relativistic heavy quark action for the charm quark. Although our main results are calculated in quenched lattice calculations, we also present a preliminary full QCD result by using the 2+1 flavor gauge configurations generated by PACS-CS Collaboration. We have found that the charmonium-nucleon potential is weakly attractive at short distances and exponentially screened at large distances. We have also successfully evaluated both the scattering length and effective range from the charmonium-nucleon scattering phase shift.
description: 13 pages, 9 figures; To appear in proceedings of 28th International Symposium on Lattice Field Theory, Lattice2010, June 14-19, 2010, Villasimius, Italy
Negation and Alternatives in Conditional Antecedents
Creators: name: McHugh, D.M.
name: Cremers, Alexandre
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2023
Subjects: subject: Humanities
subject: FOS: Humanities
subject: Information and Computing Sciences
subject: 20 Language, Communication and Culture
subject: Mathematics
subject: FOS: Mathematics

description: A number of authors, beginning with Alonso-Ovalle (2006), have used conditional antecedents to argue for the presence of alternatives in semantics. In this tradition, recent experimental work from Ciardelli et al. (2018b) and Schulz (2018) uses data from conditional antecedents to investigate the interaction between negation and alternatives. We contribute to this line of inquiry with an experiment to test a number of semantics of conditionals through their predictions on the relationship between alternatives and negation (namely, Fine, 2012; Alonso-Ovalle, 2006; Ciardelli et al., 2018b; Willer, 2018; Schulz, 2018). We find experimental support for a variant of Schulz’s theory and against all other accounts we consider.
Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs
Creators: name: Bellavita, Rosa
name: Falanga, Annarita
name: Buommino, Elisabetta
name: Merlino, Francesco
name: Casciaro, Bruno
name: Cappiello, Floriana
name: Mangoni, Maria Luisa
name: Novellino, Ettore
name: Catania, Maria Rosaria
name: Paolillo, Rossella
name: Grieco, Paolo
name: Galdieroa, Stefania
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: The rapid development of antimicrobial resistance is pushing the search in the discovering of novel antimicrobial molecules to prevent and treat bacterial infections. Self-assembling antimicrobial peptides, as the lipidated peptides, are a novel and promising class of molecules capable of meeting this need. Based on previous work on Temporin L analogs, several new molecules lipidated at the N- or and the C-terminus were synthesised. Our goal is to improve membrane interactions through finely tuning self-assembly to reduce oligomerisation in aqueous solution and enhance self-assembly in bacterial membranes while reducing toxicity against human cells. The results here reported show that the length of the aliphatic moiety is a key factor to control target cell specificity and the oligomeric state of peptides either in aqueous solution or in a membrane-mimicking environment. The results of this study pave the way for the design of novel molecules with enhanced activities.
Failed theories of superconductivity
Creators: name: Schmalian, Joerg
Publisher: name: arXiv
Year: 2010
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Almost half a century passed between the discovery of superconductivity by Kamerlingh Onnes and the theoretical explanation of the phenomenon by Bardeen, Cooper and Schrieffer. During the intervening years the brightest minds in theoretical physics tried and failed to develop a microscopic understanding of the effect. A summary of some of those unsuccessful attempts to understand superconductivity not only demonstrates the extraordinary achievement made by formulating the BCS theory, but also illustrates that mistakes are a natural and healthy part of the scientific discourse, and that inapplicable, even incorrect theories can turn out to be interesting and inspiring.
description: 14 pages, 3 figures (typos fixed), to appear in: Bardeen Cooper and Schrieffer: 50 YEARS, edited by Leon N Cooper and Dmitri Feldman
Coherent Detector Arrays for Millimeter and Submillimeter Astronomy
Creators: name: Goldsmith, Paul F.
name: Carpenter, John M.
name: Erickson, Neal
name: Fisher, Rick
name: Ford, John
name: Todd, Gaier
name: Groppi, Chris
name: Harris, Andy
name: Mark, Heyer
name: Kulesa, Craig
name: Lawrence, Charles
name: Morgan, Matt
name: Mundy, Lee
name: Narayanan, Gopal
name: O'Neil, Karen
name: Readhead, Tony
name: Samoska, Lorene
name: Schloerb, Peter
name: Snell, Ronald
name: Walker, Christopher C.
name: Ziurys, Lucy
Publisher: name: Keck Institute for Space Studies
Year: 2009

description: Progress in many areas of astronomy requires large-area surveys and observations of
extended objects. This includes the cosmic microwave background, nearby galaxies, the
Milky Way, and regions of star-forming regions within our galaxy. The ability to carry
out such studies is critically dependent on the development of affordable high-sensitivity
focal plane arrays, for both spectral line and continuum observations. We discuss a
program for the next decade to develop such technology for ground-based and spacebased
millimeter and submillimeter astronomy. Appropriate technologies exist, but
significant effort is required to make the transition from simply replicating individual
pixels to approaching focal plane array design in an integrated fashion from feeds to
spectrometers for spectral analysis. This advance is essential to realize the full potential
of major new ground-based, suborbital, and future space facilities, and is relevant to the
RMS and EOS panels. The recommended budget for this activity is $65M.
Einfluss der Implantation inverser Schulterendoprothesen bei einer proximalen Humerusfraktur auf die gesundheitsbezogene Lebensqualität
Creators: name: Willert, Thomas
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Diese prospektive Studie bestätigt den klinischen Eindruck, dass proximale Humerusfrakturen einen nachhaltigen Einfluss auf die Lebensqualität haben. Es konnte gezeigt werden, dass die Implantation einer inversen Frakturprothese einige der Dimensionen der HRQOL beeinflusst. Dies unterstützt die Hypothese, dass der Gesundheitszustand dieser Patienten über rein funktionelle Parameter hinaus beeinflusst wird. Sowohl anhand der eigenen Ergebnisse als auch nach der aktuellen Datenlage kann kein Verfahren zu Behandlung der proximalen Humerusfraktur als Verfahren der Wahl herausgearbeitet werden.
ИССЛЕДОВАНИЕ ЗНАЧЕНИЯ СЛОВА В ИНДИВИДУАЛЬНОМ ЯЗЫКОВОМ СОЗНАНИИ С ИСПОЛЬЗОВАНИЕМ МЕТОДА СЕМАНТИЧЕСКОЙ ПРОЕКЦИИ
Creators: name: Сообщество рецензентов Международного научно-исследовательского журнала
Publisher: name: ООО Цифра
Year: 2023
Subjects: word meaning
semantic differential
distributive semantics
distributive semantic models
associative experiment
значение слова
семантический дифференциал
дистрибутивная семантика
дистрибутивные семантические модели
ассоциативный эксперимент

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
The Effect of Intradialytic Exercise on Calcium, Phosphorus and Parathyroid Hormone: study protocol for a randomized controlled trial
Creators: name: Tabibi, Mohammad ali
name: Wilund, Kenneth R
name: Salimian, Nasrin
name: Nikbakht, Saghar
name: Sleymany, Mahsa
name: Roshanaeian, Zahra
name: Nazemi, Farzad
name: Ahmadi, Saghar
Publisher: name: figshare
Year: 2023
Subjects: Allied health and rehabilitation science not elsewhere classified

description: The purpose of this study is to check if patients' exercise during their dialysis sessions can improve the blood parameters which affect the heart disease and osteoporosis, so that we can help patients live longer.
Einfluss von Azathioprin und Azacitidin auf den Methylierungsstatus und die transkriptionelle Aktivität humaner endogener Retroviren im kolorektalen Karzinom
Creators: name: Weber, Lorenz Konstantin
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Die Überexpression einer spezifischen Familie humaner endogener Retroviren (HERV-H) kann mit der Entstehung kolorektaler Karzinome (KRK) assoziiert sein. Gleichzeitig stellt sie eine mögliche immuntherapeutische Zielstruktur dar. Nach Messung der basalen HERV-H Expression in bis zu 26 KRK-Zelllinien ("Screening") wurden ausgewählte Vertreter in vitro mit potenziell demethylierenden Medikamenten behandelt, um somit eine Induktion der HERV-H herbeizuführen. Dies gelang mit dem DNA-Methyltransferaseinhibitor Azacitidin.
N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation
Creators: name: Li, Wei-Yi
name: Ni, Wei-Wei
name: Ye, Ya-Xi
name: Fang, Hai-Lian
name: Pan, Xing-Ming
name: He, Jie-Ling
name: Zhou, Tian-Li
name: Yi, Juan
name: Liu, Shan-Shan
name: Zhou, Mi
name: Xiao, Zhu-Ping
name: Zhu, Hai-Liang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which act as effective urease inhibitors with very low cytotoxicity. One compound (b19) was evaluated in detail and shows promising features for further development as an agent to treat H. pylori caused diseases. Excellent values for the inhibition of b19 against both extracted urease and urease in intact cell were observed, which shows IC50 values of 0.16 ± 0.05 and 3.86 ± 0.10 µM, being 170- and 44-fold more potent than the clinically used drug AHA, respectively. Docking simulations suggested that the monosubstituted thiourea moiety penetrates urea binding site. In addition, b19 is a rapid and reversible urease inhibitor, and displays nM affinity to urease with very slow dissociation (k off=1.60 × 10−3 s−1) from the catalytic domain.
High-Performance Algorithm for Calculating Non-Spurious Spin- and Parity-Dependent Nuclear Level Densities
Creators: name: Sen'kov, R. A.
name: Horoi, M.
name: Zelevinsky, V. G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A new high-performance algorithm for calculating the spin- and parity-dependent shell model nuclear level densities using methods of statistical spectroscopy in the proton-neutron formalism was recently proposed. When used in valence spaces that cover more than one major harmonic oscillator shell, this algorithm mixes the genuine intrinsic states with spurious center-of-mass excitations. In this paper we present an advanced algorithm, based on the recently proposed statistical moments method, that eliminates the spurious states. Results for unnatural parity states of several sd-shell nuclei are presented and compared with those of exact shell model calculations and experimental data.
description: 8 pages, 5 figures
Coherent Arrays for Astronomy and Remote Sensing - Final Report
Creators: name: Readhead, A. C. S.
name: Cleary, Kieran
name: Lawrence, Charles
Publisher: name: Keck Institute for Space Studies
Year: 2016

description: The Coherent Arrays for Astronomy and Remote Sensing Program sponsored by the
Keck Institute for Space Studies has had a profound impact on astronomy at Caltech –
both at JPL and on campus – and worldwide. It provided funds for the establishment of a
world-class coherent detector laboratory – the Cahill Radio Astronomy Laboratory
(CRAL) that, in collaboration with JPL and Northrop Grumman, now sets the global
standard in coherent detectors in the centimeter-millimeter wavelength range – as shown
by three key highlights: (i) NRAO’s recent selection of CRAL MMIC detectors over its
own in house MIC detectors for the upgrade of the ALMA Band 2 receivers; (ii) NSF’s
funding of a 16-element 85 GHz – 115 GHz focal plane array (ARGUS) for the Green
Bank Telescope ($1M); and (iii) NSF’s funding of the 26 GHz – 34 GHz CO Mapping
Array Pathfinder (COMAP $2.5M). The funding of COMAP was particularly important
since it demonstrated in the wake of the NSF decline of the CARMA proposal (2014) that
the US astronomy community and the NSF were prepared to fund large new projects at
the Owens Valley Radio Observatory (OVRO), enabling the OVRO to re-establish itself
as a world-class radio observatory and convincing Caltech to continue its funding of the
OVRO. It is no exaggeration that the KISS coherent detector program played THE major
role in saving the OVRO. The position of the CRAL and of the OVRO is now very
strong and the staff, decimated by the CARMA decline, is being rebuilt and is once more
at a robust strength. Two new multi-national partnerships – the Radio Astronomy
Partnership (RAP) and the MMIC Partnership (MMICP) have been established at Caltech
as a direct result of the KISS investment in creating the CRAL, and these are providing
independent funding to OVRO and the CRAL. There are now eight agency-funded
programs at the OVRO and we are optimistic about the prospects of having two more
programs funded in the next year, in view of important science breakthroughs at OVRO
over the last 6 months.
In Silico Synchronization of Cellular Populations Through Expression Data Deconvolution
Creators: name: Eisenberg, Marisa C.
name: Ash, Joshua N.
name: Siegal-Gaskins, Dan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: Cellular populations are typically heterogenous collections of cells at different points in their respective cell cycles, each with a cell cycle time that varies from individual to individual. As a result, true single-cell behavior, particularly that which is cell-cycle--dependent, is often obscured in population-level (averaged) measurements. We have developed a simple deconvolution method that can be used to remove the effects of asynchronous variability from population-level time-series data. In this paper, we summarize some recent progress in the development and application of our approach, and provide technical updates that result in increased biological fidelity. We also explore several preliminary validation results and discuss several ongoing applications that highlight the method's usefulness for estimating parameters in differential equation models of single-cell gene regulation.
description: accepted for the 48th ACM/IEEE Design Automation Conference
Adaptive Multi-Functional Space Systems for Micro-Climate Control
Creators: name: Quadrelli, Marco
name: Lyke, James E.
name: Pellegrino, Sergio
Publisher: name: Keck Institute for Space Studies
Year: 2015

description: This report summarizes the work done during the Adaptive Multifunctional Systems for Microclimate
Control Study held at the Caltech Keck Institute for Space Studies (KISS) in 2014-2015.
Dr. Marco Quadrelli (JPL), Dr. James Lyke (AFRL), and Prof. Sergio Pellegrino (Caltech) led
the Study, which included two workshops: the first in May of 2014, and another in February
of 2015. The Final Report of the Study presented here describes the potential relevance of
adaptive multifunctional systems for microclimate control to the missions outlined in the 2010
NRC Decadal Survey.

The objective of the Study was to adapt the most recent advances in multifunctional reconfigurable
and adaptive structures to enable a microenvironment control to support space exploration in
extreme environments (EE). The technical goal was to identify the most efficient materials,
architectures, structures and means of deployment/reconfiguration, system autonomy and energy
management solutions needed to optimally project/generate a micro-environment around space
assets. For example, compact packed thin-layer reflective structures unfolding to large areas
can reflect solar energy, warming and illuminating assets such as exploration rovers on Mars or
human habitats on the Moon. This novel solution is called an energy-projecting multifunctional
system (EPMFS), which are composed of Multifunctional Systems (MFS) and Energy-Projecting
Systems (EPS).
Термины родства и свойства в удмуртских свадебных песнях
Creators: name: Закирова, Наталия
Publisher: name: ООО Цифра
Year: 2023
Subjects: Udmurt wedding
Udmurt language
kinship and property terms
wedding songs
archival materials
cultural semantics
удмуртская свадьба
удмуртский язык
термины родства и свойства
свадебные песни
архивные материалы
культурная семантика

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Effect of amorphous rice husk silica addition on the structure of asphalt composite
Creators: name: Sembiring, Simon
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Rice husk
Silica
Asphalt
Microstructure
Structure

description: Journal of Metals, Materials and Minerals, 30, 4, 113-118
Персонажный культурный код в хоронимах Лондона
Creators: name: Сообщество рецензентов Международного научно-исследовательского журнала
Publisher: name: ООО Цифра
Year: 2023
Subjects: linguoculturology
English language
cultural code
anthroponym
choronym
лингвокультурология
английский язык
культурный код
антропоним
хороним

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Influence of coconut shell powder organic reinforcement on chemical, microstructural and mechanical properties of spark plasma sintered Ti-Ni based metal matrix composite
Creators: name: Odetola, Peter
Publisher: name: Metallurgy and Materials Science Research Institute Chulalongkorn University
Year: 2020
Subjects: Titanium
Nickel
Spark plasma sintering
Coconut shell powder
Microhardness

description: Journal of Metals, Materials and Minerals, 30, 4, 119-127
Chronisch entzündliche und virale Vorerkrankungen sind Risikofaktoren der Streptokokken-induzierten septischen Arthritis
Creators: name: Volzke, Johann
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 500 Natural sciences
subject: 610 Medical sciences Medicine

description: Die septische Arthritis (SA) ist eine infektiöse Gelenkerkrankung, bei der Entzündungsreaktionen zu schweren Schäden des Bewegungsapparats führen. Bis heute ist nicht geklärt, inwieweit Gelenkzellen zur Entstehung der Pathologie der SA beitragen, und ob Verkrankungen das Auftreten und die Schwere der SA beeinflussen. In dieser Studie wurde demonstriert, dass synoviale Fibroblasten in der Lage sind, Entzündungsreaktionen zu initiieren. Des weiteren konnte gezeigt werden, dass sowohl eine chronisch entündliche Vorerkrankung der Gelenke als auch eine Influenza A Virus Infektion die SA exazerbierte.
The Effect of Intradialytic Exercise on Calcium, Phosphorus and Parathyroid Hormone: study protocol for a randomized controlled trialem
Creators: name: Tabibi, Mohammad ali
name: Wilund, Kenneth R
name: Salimian, Nasrin
name: Nikbakht, Saghar
name: Sleymany, Mahsa
name: Roshanaeian, Zahra
name: Nazemi, Farzad
name: Ahmadi, Saghar
Publisher: name: figshare
Year: 2023
Subjects: Allied health and rehabilitation science not elsewhere classified

description: The purpose of this study is to check if patients' exercise during their dialysis sessions can improve the blood parameters which affect the heart disease and osteoporosis, so that we can help patients live longer.
Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in colorectal cancer cells
Creators: name: Lu, Lili
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 500 Natural sciences
subject: 610 Medical sciences Medicine

description: The present study aimed at 1) testing the sensitivity of CRC cell lines with defined molecular alterations to curcumin; 2) mechanistically analyzing sensitive CRC cell lines in order to identify the mode-of-action; 3) identifying biomarkers associated with curcumin sensitivity; 4) establishing a predictive model using biomarkers to predict the sensitivity of additional CRC cell line to curcumin.
Planetary Magnetic Fields: Planetary Interiors and Habitability
Creators: name: Lazio, Joseph
name: Shkolnik, Evgenya
name: Hallinan, Gregg
Publisher: name: Keck Institute for Space Studies
Year: 2016

description: Soon after its detection, radio emission from Jupiter was quickly identified as a product of its
planetary-scale magnetic field. Subsequent spacecraft investigations have revealed that many of
the planets—and even some moons—either currently have or have had in the past a planetaryscale
magnetic field. Generated by dynamo processes within the planet, planetary-scale magnetic
fields provide a means of constraining the properties of a planet’s interior through remote sensing,
and it may even be possible to measure the magnetic fields of extrasolar planets. If so, they will
offer one of the few means available of understanding the potential diversity of planetary interiors.
In the case of our own planet, the presence of Earth’s magnetic field has long been suspected to
be partially responsible for its habitability. Thus, knowledge of the magnetic field of an extrasolar
planet may be a valuable component to assess its habitability, or to understand an absence of life
on an otherwise potentially habitable planet.
This report summarizes the investigations and conclusions from a William M. Keck Institute for
Space Studies on planetary magnetic fields.
Behandlungsergebnisse bei therapierefraktären Epilepsien durch eine spezialisierte epileptologische Betreuung
Creators: name: Prasse, Theresa
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Trotz zahlreicher neuer AEDs sind weiterhin ca. 25% aller Patienten mit Epilepsie nach einer ersten antikonvulsiven Therapie nicht anfallsfrei. 70 Patienten der Spezialsprechstunde für Epilepsie in Rostock konnten zwischen 2009 und 2013 eingeschlossen und ausgewertet werden. Beim letzten Kontakt waren 15,7% der Patienten mindestens 1 Jahr anfallsfrei und weitere 45,6% hatten eine mind. 50%ige Reduktion der Anfallsfrequenz. Im Rahmen einer spezialisierten epileptologischen Betreuung lassen sich bei mind. 60% der Patienten substanzielle Verbesserungen in Bezug auf die Anfallsfrequenz erreichen.
Extracting scattering parameters using the isospin chemical potential
Creators: name: Buchoff, Michael I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Hadronic scattering mediated through the strong interaction has been an area of great interest for both theory and experiment. Recently, lattice QCD calculations of scattering processes from first principles have seen remarkable progress, including multiple calculations of two-pion scattering lengths that agree with experiment to within a few percent. However, there exists a certain class of scattering processes, such as pion-nucleon scattering, that contain annihilation diagrams, which are often prohibitively expensive to simulate on the lattice. In this talk, I will present a method to extract certain parameters from this class of scattering processes by employing an isospin chemical potential, which can be simulated on the lattice as a result of its positive-definite fermion determinant.
description: 7 pages, 3 figures, talk given at the XXVIII International Symposium on Lattice Field Theory (Lattice 2010), June 14-19 2010, Villasimius, Italy
Формирование общественных взглядов посредством медиадискурса
Creators: name: Труфанов, Глеб
Publisher: name: ООО Цифра
Year: 2023
Subjects: ideology
public opinion formation
mass media
media discourse
идеология
формирование общественного мнения
СМИ
медиадискурс

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Implications of Standard-Model flavor violation for new physics searches
Creators: name: Gardner, Susan
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: I discuss far-flung ramifications of light-quark flavor physics for searches for physics beyond the Standard Model and consider, particularly, its role in the interpretation of CP-violating observables in meson decays.
description: 6 pages, 2 figures
Bridging the Gap: Observations and Theory of Star Formation Meet on Large and Small Scales
Creators: name: Pineda, Jorge L.
name: Hopkins, Philip F.
Publisher: name: Keck Institute for Space Studies
Year: 2015

description: The drive to understand galaxy formation and evolution over the lifetime of the universe has justified vast space-based and ground-based telescope facilities, as well as the development of new technologies. The details of star formation, and the modes by which that activity couples to the broader galactic environment, occurs on small spatial scales. These scales can only be traced with great sophistication in the local universe, as witnessed by observations using the Spitzer Space Telescope, the Herschel Space Observatory, the Stratospheric Observatory for Infrared Astronomy (SOFIA), and the Atacama Large Millimeter Array (ALMA). A critical realization of the last decade, however, is that the large scales and small scales are strongly coupled, and cannot be treated in isolation. At the same time, the scales studied in the local universe are "sub-grid"
for the purpose of cosmological simulations that make valiant efforts to include the physics of star formation and its feedback to the local environment. The fundamental uncertainties in how this sub-grid physics is incorporated into the larger picture are by far the greatest limitation in understanding galaxy formation and evolution.

The main goal of cosmological simulations is to understand the formation and evolution of the universe over a wide range of scales going from the Hubble volume to sub-light-year scales within galaxies. However, due to computational limitations, the physics of star formation in galaxies and the effects this process has on the formation and evolution of galaxies are often greatly simplified.
For instance, accounting for the effect of stellar feedback in cosmological simulations is a crucial factor in galaxy formation and evolution. Without stellar feedback in galaxies, the gas would rapidly cool and collapse, converting all available gas into stars within a dynamical time. This consequence is in sharp conflict with observations—there are vastly fewer stars in our universe
than the models would predict. Until recently, numerical simulations have been unable to regulate star formation efficiently enough to reproduce observations, with many consequences: models with too many stars also predict they form at the wrong times in the universe’s history, that there are the wrong abundances of heavy elements, that galaxies look nothing like the Milky Way, and even that the observable properties of dark matter are (apparently) discordant with new
precision-cosmology measurements. All of these problems may, in fact, be due to the fundamental problem of understanding how small and large scales interact.
New insights into active transportation safety : a macro-level analysis framework
Creators: name: Amer, Ahmed Osama
Publisher: name: University of British Columbia
Year: 2018

description: City councils worldwide have shown an increasing interest in active transportation (AT) due to its health, environmental, and economical benefits. However, active commuters are vulnerable to severe crash risk, which is a deterrent to active travel. Therefore, there is a need for developing systematic approaches to improve AT safety. This dissertation introduces a comprehensive framework for identifying, diagnosing and remedying the macro-level AT safety issues. It provides original insights into AT networks, crash models (CM), crash hot zones identification (HZID), and policy recommendations. Data were collected from 134 traffic analysis zones (TAZs) in the City of Vancouver. Cyclist and pedestrian crash data, traffic exposure and large GIS data were incorporated in the analysis. The GIS data integrated various land use, built environment, socioeconomic, and road facility features. Moreover, bike and pedestrian network indicators, developed using graph-theory and representing connectivity, continuity, and topography of the networks, were incorporated. The state of the practice empirical Bayesian (EB) method and the state of the art full Bayesian (FB) methods were adopted for the CMs’ development and HZID. Various FB model forms were investigated, and the Spatial Poisson-Lognormal model performed the best. Cyclist and pedestrian crashes were found positively associated with various attributes of network-connectivity, socio-demographics, built environment, arterial-collector roads, and commercial areas. Conversely, the crashes were negatively associated with various attributes of network-directness, network-topography, residential areas, recreational areas, local roads, separated paths, and actuated signals. Most of the safety correlates had similar effects for the pedestrian and cyclist crashes. Accordingly, mixed multi-response FB CMs were developed and the correlation between pedestrian and cyclist crashes was found significant. The univariate/multivariate CMs with spatial effects consistently outperformed those without, and the multivariate CMs generally outperformed the univariate ones. AT crash hot-zones were then identified using the novel Mahalanobis distance and the conventional potential for safety improvement (PSI) methods, and consistency tests were applied to compare both. Afterwards, trigger variables were statistically identified for the crash hot and safe zones. Lastly, remedies regarding land use, traffic demand, and traffic supply management were proposed based on the trigger variables’ analysis, field studies, and literature consultation.
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors
Creators: name: Velnati, Suresh
name: Massarotti, Alberto
name: Antona, Annamaria
name: Talmon, Maria
name: Fresu, Luigia Grazia
name: Galetto, Alessandra Silvia
name: Capello, Daniela
name: Bertoni, Alessandra
name: Mercalli, Valentina
name: Graziani, Andrea
name: Tron, Gian Cesare
name: Baldanzi, Gianluca
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: A series of analogues of Amb639752, a novel diacylglycerol kinase (DGK) inhibitor recently discovered by us via virtual screening, have been tested. The compounds were evaluated as DGK inhibitors on α, θ, and ζ isoforms, and as antagonists on serotonin receptors. From these assays emerged two novel compounds, namely 11 and 20, which with an IC50 respectively of 1.6 and 1.8 µM are the most potent inhibitors of DGKα discovered to date. Both compounds demonstrated the ability to restore apoptosis in a cellular model of X-linked lymphoproliferative disease as well as the capacity to reduce the migration of cancer cells, suggesting their potential utility in preventing metastasis. Finally, relying on experimental biological data, molecular modelling studies allow us to set a three-point pharmacophore model for DGK inhibitors.
Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation
Creators: name: Abdelrahman, Mohamed A.
name: Eldehna, Wagdy M.
name: Nocentini, Alessio
name: Ibrahim, Hany S.
name: Almahli, Hadia
name: Abdel-Aziz, Hatem A.
name: Abou-Seri, Sahar M.
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfonamide moiety linked to a benzofuran tail via a hydrazine or hydrazide linker. All the target benzofurans were examined for their inhibitory activities toward isoforms hCA I, II, IX, and XII. The target tumour-associated hCA IX and XII isoforms were efficiently inhibited with K Is spanning in ranges 10.0–97.5 and 10.1–71.8 nM, respectively. Interestingly, arylsulfonehydrazones 9 displayed the best selectivity toward hCA IX and XII over hCA I (SIs: 39.4–250.3 and 26.0–149.9, respectively), and over hCA II (SIs: 19.6–57.1 and 13.0–34.2, respectively). Furthermore, the target benzofurans were assessed for their anti-proliferative activity, according to US-NCI protocol, toward a panel of sixty cancer cell lines. Only benzofurans 5b and 10b possessed selective and moderate growth inhibitory activity toward certain cancer cell lines.