cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regiones en el plano complejo, software Mathematica y habilidades matemáticas y digitales
Creators: name: Favieri, Adriana
Publisher: name: figshare
Year: 2019
Subjects: Education

description: El diseño de actividades de enseñanza aprendizaje en el cual se utiliza software matemático y enfocado al desarrollo de habilidades matemáticas y digitales, es una tarea docente esencial y necesita tanto de conocimientos matemáticos, del software y sobre las habilidades matemáticas. En este trabajo se presenta el diseño de actividades con estas características sobre el tema: regiones en el plano complejo. Se muestran las actividades, su relación con las habilidades matemáticas y digitales y las evidencias de las mismas en el software. Se concluye sobre la tarea docente necesaria para estos diseños, el conocimiento sobre el software y sobre las habilidades matemáticas y digitales.
Additional file 11 of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Creators: name: Ajnakina, Olesya
name: Agbedjro, Deborah
name: McCammon, Ryan
name: Faul, Jessica
name: Murray, Robin M.
name: Stahl, Daniel
name: Steptoe, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: Additional file 11. Histogram depicting distribution of prognostic index (PI) estimated based on 13 variables included in the model in the development cohort and external cohort.
Extent of atherosclerosis after 11-year prospective follow-up in patients with early rheumatoid arthritis was affected by disease severity at diagnosis
Creators: name: I Björsenius
name: S Rantapää-Dahlqvist
name: E Berglin
name: A Södergren
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: Cardiovascular disease (CVD) is increased among patients with rheumatoid arthritis (RA). The underlying cause is not clear. In this prospective study, patients with early RA were investigated for associations between subclinical atherosclerosis and CVD risk factors as well as inflammation. Method: At diagnosis, RA patients were recruited into a prospective study. A subgroup was included (n = 55) for ultrasound measurements of intima–media thickness (IMT) at inclusion (T0), and after 5 years (T5) and 11 years (T11). Thirty-one age and gender-matched controls were also included for comparison. Results: IMT increased significantly between T0 and T11 among patients and controls (p 0.05 for all). In simple regression models, IMT at T11 was significantly associated with age (p Conclusion: We found increased atherosclerotic development among patients with RA compared with controls 11 years after diagnosis. The atherosclerotic burden was associated with disease severity at baseline.
Additional file 12 of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Creators: name: Ajnakina, Olesya
name: Agbedjro, Deborah
name: McCammon, Ryan
name: Faul, Jessica
name: Murray, Robin M.
name: Stahl, Daniel
name: Steptoe, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: Additional file 12. The distribution of survival probabilities estimated based on 13 variables included in the model in the development and validation cohorts.
Neocollyris (Neocollyris)
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Neocollyris

description: 45. Neocollyris (Neocollyris) ru  fi palpis (Chaudoir, 1864) (Fig. 45, 242)
 Collyris (Neocollyris) rufipalpis: Horn 1902: 66; 1913: 363; 1924: 8.
 Neocollyris (Neocollyris) rufipalpis: Naviaux 1995a: 147, 148; Matalin 2015b: 618.
 Published data. NORTHEAST: Lang Son (Than Moi) (Horn 1902: 66; 1913: 363; 1924: 8).
 Distribution. Vietnam (Lang Son), China (Fujian, Guangdong, Hainan, Jiangxi, Yunnan, Zhejiang), Laos (Borikhamxay, Houaphanh, Luangnamtha, Luangprabang, Oudomxay, Xayabury), Cambodia, Thailand (Chiang Mai, Phitsanulok, Phrae, Ratchaburi), Myanmar, India (Assam), Nepal, Malaysia (Malacca, Borneo), Indonesia (Jawa).
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 20, DOI: 10.5281/zenodo.5169363
Additional file 13 of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Creators: name: Ajnakina, Olesya
name: Agbedjro, Deborah
name: McCammon, Ryan
name: Faul, Jessica
name: Murray, Robin M.
name: Stahl, Daniel
name: Steptoe, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: Additional file 13. Distributions of the variables included in the final all-cause mortality model in derivation cohort (ELSA) and validation cohort (HRS).
Auxetic tetrahex-carbon with ultrahigh strength and direct band gap
Creators: name: Wei, Qun
name: Yang, Guang
name: Peng, Xihong
Publisher: name: arXiv
Year: 2019
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Tetrahex-carbon is a recently predicted two dimensional (2D) carbon allotrope which is composed of tetragonal and hexagonal rings. Unlike flat graphene, this new 2D carbon structure is buckled, possesses a direct band gap ~ 2.6 eV and high carrier mobility with anisotropic feature. In this work, we employ first-principles density-functional theory calculations to explore mechanical properties of tetrahex-C under uniaxial tensile strain. We find that tetrahex-C demonstrates ultrahigh ideal strength, outperforming both graphene and penta-graphene. It shows superior ductility and sustains uniaxial tensile strain up to 20% (16%) till phonon instability occurs, and the corresponding maximal strength is 38.3 N/m (37.8 N/m) in the zigzag (armchair) direction. It shows intrinsic negative Poisson's ratio. This exotic in-plane Poisson's ratio takes place when axial strain reaches a threshold value of 7% (5%) in the zigzag (armchair) direction. We also find that tetrahex-C holds a direct band gap of 2.64 eV at the center of Brillouin zone. This direct-band-gap feature maintains intact upon strain application with no direction-indirect gap transition. The ultrahigh ideal strength, negative Poisson's ratio and integrity of direct-gap under strain in tetrahex-C suggest it may have potential applications in nanomechanics and nanoelectronics.
description: 14 pages, 7 figures
Ultrafast quasiparticle relaxation dynamics in normal metals and heavy fermion materials
Creators: name: Ahn, K. H.
name: Graf, M. J.
name: Trugman, S. A.
name: Demsar, J.
name: Averitt, R. D.
name: Sarrao, J. L.
name: Taylor, A. J.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a detailed theoretical study of the ultrafast quasiparticle relaxation dynamics observed in normal metals and heavy fermion materials with femtosecond time-resolved optical pump-probe spectroscopy. For normal metals, a nonthermal electron distribution gives rise to a temperature (T) independent electron-phonon relaxation time at low temperatures, in contrast to the T^{-3}-divergent behavior predicted by the two-temperature model. For heavy fermion compounds, we find that the blocking of electron-phonon scattering for heavy electrons within the density-of-states peak near the Fermi energy is crucial to explain the rapid increase of the electron-phonon relaxation time below the Kondo temperature. We propose the hypothesis that the slower Fermi velocity compared to the sound velocity provides a natural blocking mechanism due to energy and momentum conservation laws.
description: 10 pages, 11 figures
Asymptotically (anti)-de Sitter solutions in Gauss-Bonnet gravity without a cosmological constant
Creators: name: Dehghani, M. H.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we show that one can have asymptotically de Sitter (dS), anti-de Sitter (AdS) and flat solutions in Gauss-Bonnet gravity without any need to a cosmological constant term in field equations. First, we introduce static solutions whose 3-surfaces at fixed $r$ and $t$ have constant positive ($k=1$), negative ($k=-1$), or zero ($k=0$) curvature. We show that for $k=\pm1$, one can have asymptotically dS, AdS and flat spacetimes, while for the case of $k=0$, one has only asymptotically AdS solutions. Some of these solutions present naked singularities, while some others are black hole or topological black hole solutions. We also find that the geometrical mass of these 5-dimensional spacetimes is $m+2α| k| $, which is different from the geometrical mass, $m $, of the solutions of Einstein gravity. This feature occurs only for the 5-dimensional solutions, and is not repeated for the solutions of Gauss-Bonnet gravity in higher dimensions. We also add angular momentum to the static solutions with $k=0$, and introduce the asymptotically AdS charged rotating solutions of Gauss-Bonnet gravity. Finally, we introduce a class of solutions which yields an asymptotically AdS spacetime with a longitudinal magnetic field which presents a naked singularity, and generalize it to the case of magnetic rotating solutions with two rotation parameters.
description: 13 pages, no figure
1,3,4-oxadiazole derivatives: synthesis, characterization, antifungal activity, DNA binding investigations, TD-DFT calculations, and molecular modelling
Creators: name: Mehandi, Rabiya
name: Twala, Charmy
name: Ahmedi, Saiema
name: Fatima, Aysha
name: Islam, Khursheed ul
name: Rana, Manish
name: Sultana, Razia
name: Manzoor, Nikhat
name: Javed, Saleem
name: Haque, Mohammad Mahfuzul
name: Iqbal, Jawed
name: Rahisuddin
name: Nishat, Nahid
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Cell Biology
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: 1,3,4-Oxadiazole-based heterocyclic analogs (3a–3m) were synthesized via cyclization of Schiff bases with substituted aldehydes in the presence of bromine and acetic acid. The structural clarification of synthesized molecules was carried out with various spectroscopic techniques such as FT-IR,1H and 13C-NMR, UV–visible spectroscopy, and mass spectrometry. In-vitro antifungal activity was performed against C. albicans, C. glabrata and C. tropicalis and analogs 3g, 3i, and 3m showed potent MIC at 200 µg/ml and excellent ZOI measurements of 17–21 nm. The cell viability on Huh7 for lead molecules 3g, 3i, and 3m was found to be 99.5%, 92.3%, and 86.9% at 20, 10, and 20 μM, respectively. The antioxidant activity of molecules 3 g, 3i, and 3 m was estimated and exhibited great IC50 values of 0.104 ± 0.021, 0.145 ± 0.05, and 0.165 ± 0.018 μg/mL with DPPH and 0.107 ± 0.04, 0.191 ± 0.12, and 0.106 ± 0.08 with H2O2, respectively. The binding interaction mode for the lead molecules was also carried out with Ct-DNA using the absorption, emission, CV, CD, and Time resolve fluorescence techniques. The results showed good binding constant (Kb) values of 9.1 × 105, 9.94 × 105, and 9.32 × 105 M−1 for 3g, 3i, and 3m, respectively. TD-DFT study of compounds 3g, 3i, and 3m was done to find out HOMO/LUMO energy levels, surface study of the molecular electrostatic potential, Mulliken population analysis, and natural bond orbitals showing the linkages between the donors and acceptors.Molecular docking of three lead analogs with PDB ID: 1BNA and molecular modelling of compounds 3g, 3i, and 3m with C. albicans CYP51 protein (PDB ID: 5FSA) were carried out.
Characteristics of patients with familial Mediterranean fever in Denmark: a retrospective nationwide register-based cohort study
Creators: name: SB Mortensen
name: AE Hansen
name: J Lundgren
name: TS Barfod
name: L Ambye
name: M Dunø
name: C Schade Larsen
name: DC Andersen
name: MA Jakobsen
name: IS Johansen
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Objectives: To investigate epidemiology, demography, and genetic and clinical characteristics of patients with familial Mediterranean fever (FMF) in Denmark. Method: In this population-based, cross-sectional cohort study, we identified FMF patients from discharge diagnoses using ICD-10 codes in the Danish National Patient Register, and linked data from the Danish Civil Registration System and laboratory databases for results of MEFV gene variant screening. Results: We identified 495 FMF patients (prevalence 1:11 680) with a median age of 29 years and a female ratio of 51%. The median age at diagnosis of FMF was 13 (IQR 7–22) years, with an estimated median diagnostic delay of 3 (IQR 0.7–6.9) years. The predominant ethnicities were Turkish (41.8%), Lebanese (15.8%), Syrian (6.5%), South-West Asian (7.9%), and South-East Asian (3.0%). The MEFV genotype distribution was 18.7% homozygous, 21.2% compound heterozygous, 32.0% heterozygous, 11.0% with complex alleles or unresolved zygosity, and 17.1% with no detected variants. M694V was the most prevalent variant in the overall cohort (32.5%). Homozygous or compound heterozygous MEFV exon 10 variants were associated with younger age at diagnosis (p Conclusions: FMF in Denmark is rare and patients are mainly of Eastern Mediterranean ethnicity. Diagnostic delay was long but patients with exon 10 MEFV variants were diagnosed at a younger age. Prolonged diagnostic delay is probably caused by lack of FMF awareness in the Danish healthcare system.
Investment in Ecotourism: Assessing its Economics
Creators: name: Tisdell, Clement A.
name: Tisdell, Clement A.
Publisher: name: Unknown
Year: 1995
Subjects: subject: Environmental Economics and Policy
subject: demand for ecotourism
subject: sustainable ecological development
subject: investment in ecotourism
subject: user-pays principle

description: After briefly defining ecotourism, factors affecting the demand for it, its relative growth and its value for nature conservation are discussed. There has been an upsurge in interest in ecotourism as a possible profitable means to ensure sustainable ecological development. However, investment in ecotourism does not always have the favourable consequences claimed for it. Investment in ecotourism may fail to give a favourable private return for reasons outlined. Factors to be taken into account in assessing private profitability of investment in ecotourism and the likely demands for it at a site are examined. Assessment of social returns from investment in ecotourism are made on a wider basis than the determination of private returns. All investment for the development of ecotourism, whether privately incurred or not, is taken into account along with any external benefits or costs generated. It may also be necessary in calculating social return to include an allowance for increased consumers' surplus obtained by ecotourists from investment in ecotourism. The user-pays principle is discusssed because social return is not necessarily dependent on payments. Nevertheless tourism development has to be financed and one source of finance is payments by tourists. The transaction costs involved in imposing fees affects the economics of charging and means to reduce such costs are considered. In conclusion, it is pointed out that investment in ecotourism is liable to cause damage to natural environments and offset policies are proposed as a way to compensate for this.
Temporal Talbot effect in interference of matter waves from arrays of Bose-Einstein condensates and transition to Fraunhofer diffraction
Creators: name: Gammal, A.
name: Kamchatnov, A. M.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We consider interference patterns produced by coherent arrays of Bose-Einstein condensates during their one-dimensional expansion. Several characteristic pattern structures are distinguished depending on value of the evolution time. Transformation of Talbot ``collapse-revival'' behavior to Fraunhofer interference fringes is studied in detail.
description: 11 pages, 4 figures; misprints corrected
Estimating dayside effective temperatures of hot Jupiters and associated uncertainties through Gaussian process regression
Creators: name: Pass, Emily K.
name: Cowan, Nicolas B.
name: Cubillos, Patricio E.
name: Sklar, Jack G.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: In this work, we outline a new method for estimating dayside effective temperatures of exoplanets and associated uncertainties using Gaussian process (GP) regression. By applying our method to simulated observations, we show that the GP method estimates uncertainty more robustly than other model-independent approaches. We find that unbiased estimates of effective temperatures can be made using as few as three broad-band measurements (white-light HST WFC3 and the two warm Spitzer IRAC channels), although we caution that estimates made using only IRAC can be significantly biased. We then apply our GP method to the twelve hot Jupiters in the literature whose secondary eclipse depths have been measured by WFC3 and IRAC channels 1 and 2: CoRoT-2 b; HAT-P-7 b; HD 189733 b; HD 209458 b; Kepler-13A b; TrES-3 b; WASP-4 b; WASP-12 b; WASP-18 b; WASP-33 b; WASP-43 b; and WASP-103 b. We present model-independent dayside effective temperatures for these planets, with uncertainty estimates that range from $\pm$66 K to $\pm$136 K.
description: 11 pages, 6 figures, accepted for publication in MNRAS
Neocollyris (Orthocollyris) crassicornis subsp. crassicornis crassicornis (Dejean 1825
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Neocollyris
Neocollyris crassicornis
Neocollyris (orthocollyris) crassicornis crassicornis (dejean, 1825)

description: 46. Neocollyris (Orthocollyris) crassicornis crassicornis (Dejean, 1825) (Fig. 46, 243)
 Collyris crassicornis subclavata: Horn 1914: 137; 1924: 9.
 Collyris crassicornis: Horn 1929: 18, 21.
 Neocollyris (Orthocollyris) crassicornis crassicornis: Naviaux 1995a: 149, 150; Matalin 2015b: 619.
 Published data. ? Dang-Trua (Horn 1914: 137; 1924: 9); NORTHEAST: Lao Cai (Sa Pa) (Horn 1929: 18); MEKONG DELTA: Tien Giang (Go Cong) (Horn 1929: 21).
 New records. NORTHEAST: Ha Giang, W of Bac Quang, mountains, 500m, leg. O. Kabakov, 13.vii.1963, 1 male (ZISP); NORTH CENTRAL COAST: Thanh Hoa, Bai Thuong, 300m, leg. O. Kabakov, 5.vii.1962, 1 female (ZISP).
 Distribution. Vietnam (Ha Giang, Lao Cai, Thanh Hoa, Tien Giang), China (Fujian, Guangdong, Guangxi, Hainan, Hong Kong, Jiangxi,?Xizang, Yunnan, Zehjiang), Taiwan, Laos (Borikhamxay, Luangnamtha, Luangprabang, Phongsaly, Vientiane, Xiengkhuang), Thailand (Khon Kaen, Mae Hong Son, Nakhon Ratchasima, Rayong), Myanmar (Shan), India (Anamalai, Madras, Kumaun, Uttar Pradesh, Arunachal Pradesh), Sri Lanka, Bangladesh, Nepal, Bhutan, Malaysia (Malacca), Indonesia (Sumatra, Jawa, Bali).
 Remarks. New provincial records for Ha Giang and Thanh Hoa.
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 20, DOI: 10.5281/zenodo.5169363
Additional file 14 of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Creators: name: Ajnakina, Olesya
name: Agbedjro, Deborah
name: McCammon, Ryan
name: Faul, Jessica
name: Murray, Robin M.
name: Stahl, Daniel
name: Steptoe, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: Additional file 14. The formula for the final model.
Social Capital and the Performance of Water User Associations: Evidence from the Republic of Macedonia
Creators: name: Sauer, Johannes
name: Gorton, Matthew
name: Peshevski, Mile
name: Bosev, Dane
name: Shekerinov, Darko
name: Sauer, Johannes
name: Gorton, Matthew
name: Peshevski, Mile
name: Bosev, Dane
name: Shekerinov, Darko
Publisher: name: Unknown
Year: 2010
Subjects: subject: Community/Rural/Urban Development
subject: Resource /Energy Economics and Policy
subject: Water User Association
subject: transition countries
subject: social capital
subject: microeconometrics
subject: Wassernutzervereinigung
subject: Transformationsländer
subject: Sozialkapital
subject: Mikroökonometrie

description: The paper assesses the performance of Water User Associations (WUAs) in the Republic of Macedonia. We assess performance in terms of membership rates, the satisfaction of members with their WUA and payment behaviour. Econometric analysis reveals that membership and satisfaction are positively related to farm size. Satisfaction and payment behaviour are strongly linked to structural and relational dimensions of social capital, particularly trust in senior managers of the WUA and the transparency with which resources are utilised. The conclusion highlights the importance of local factors in determining the success of WUAs. Dieser Beitrag fokussiert die Performanz von Water User Associations (WUAs) in Mazedonien. Diese wird bewertet anhand von Mitgliedschaftszahl, der Zufriedenheit der Mitglieder sowie Zahlungsverhalten. Die ökonometrische Analyse ergibt, dass Mitgliedschaft und Zufriedenheit positiv durch die Größe des Betriebes beeinflusst werden. Zufriedenheit und Zahlungsverhalten zeigen sich stark verbunden mit strukturellen und relationalen Charakteristiken von Sozialkapital, hier insbesondere dem Vertrauen in das Seniormanagement der WUA sowie der Transparenz der Ressourcenverwendung. Diese Ergebnisse betonen die Bedeutung lokaler Faktoren im Hinblick auf die Bestimmung des Erfolges von WUA.
Integrating network pharmacology, molecular docking and simulation approaches with machine learning reveals the multi-target pharmacological mechanism of Berberis integerrima against diabetic nephropathy
Creators: name: Zhang, Xueqin
name: Chao, Peng
name: Zhang, Lei
name: Lu, Jinyu
name: Yang, Aiping
name: Jiang, Hong
name: Lu, Chen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology

description: Diabetic nephropathy (DN) is one of the most feared complications of diabetes and key cause of end-stage renal disease (ESRD). Berberis integerrima has been widely used to treat diabetic complications, but exact molecular mechanism is yet to be discovered. Data on active ingredients of B. integerrima and target genes of both diabetic nephropathy and B.integerrima were obtained from public databases. Common results between B. integerrima and DN targets were used to create protein-protein interaction (PPI) network using STRING database and exported to Cytoscape software for the selection of hub genes based on degree of connectivity. Future, PPI network between constituents and overlapping targets was created using Cytoscape to investigate the network pharmacological effects of B. integerrima on DN. KEGG pathway analysis of core genes exposed their involvement in excess glucose-activated signaling pathway. Then, expression of core genes was validated through machine learning classifiers. Finally, PyRx and AMBER18 software was used for molecular docking and simulation. We found that Armepavine, Berberine, Glaucine, Magnoflorine, Reticuline, Quercetin inhibits the growth of diabetic nephropathy by affecting ICAM1, PRKCB, IKBKB, KDR, ALOX5, VCAM1, SYK, TBXA2R, LCK, and F3 genes. Machine learning revealed SYK and PRKCB as potential genes that could use as diagnostic biomarkers against DN. Furthermore, docking and simulation analysis showed the binding affinity and stability of the active compound with target genes. Our study revealed that B. integerrima has preventive effect on DN by acting on glucose-activated signaling pathways. However, experimental studies are needed to reveal biosafety profiles of B. integerrima in DN.
Data paper on soccer-logs
Creators: name: Pappalardo, Luca
name: Rossi, Alessio
name: Cintia, Paolo
Publisher: name: figshare
Year: 2019
Subjects: subject: 110699 Human Movement and Sports Science not elsewhere classified
subject: FOS: Health sciences
subject: 80109 Pattern Recognition and Data Mining
subject: FOS: Computer and information sciences
subject: Data Format

description: Soccer analytics is attracting increasing interest in academia and industry, thanks to the availability of sensing technologies that provide high-fidelity data streams for every match. Unfortunately, these detailed data are owned by specialized companies and hence are rarely publicly available for scientificresearch.
To fill this gap, this paper describes the largest open collection of soccer-logs ever released, containing all the spatio-temporal events (passes, shots, fouls, etc.) that occured during each match for an entire season of seven prominent soccer competitions.
Each match event contains information about its position, time, outcome, player and characteristics. The nature of team sports like soccer, halfway between the abstraction of a game and the reality of complex social systems, combined with the unique size and composition of this dataset, provide an ideal ground for tackling a wide range of data science problems, including the measurement and evaluation of performance, both at individual and at collective level, and the determinants of success and failure.
Cite this article: Pappalardo, L., Cintia, P., Rossi, A. et al. A public data set of spatio-temporal match events in soccer competitions. Sci Data 6, 236 (2019) doi:10.1038/s41597-019-0247-7
Link to paper online: https://www.nature.com/articles/s41597-019-0247-7.pdf
Elevated adiponectin predicts the development of rheumatoid arthritis in subjects with obesity
Creators: name: Y Zhang
name: M Peltonen
name: JC Andersson-Assarsson
name: P-A Svensson
name: C Herder
name: A Rudin
name: LMS Carlsson
name: C Maglio
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective The aim of the current study is to determine whether baseline serum adiponectin levels predict the development of rheumatoid arthritis (RA). Method The current report includes 3693 individuals from the Swedish Obese Subjects (SOS) study. The original SOS study is a longitudinal non-randomized controlled study aiming to assess the effect of bariatric surgery on obesity-related mortality and morbidity. Participants included in the present report had adiponectin measurement available at baseline and no prevalent RA. The diagnosis of RA was retrieved through the Swedish National Patient Register. Results During a follow-up for up to 29 years, 82 study participants developed RA. Elevated baseline adiponectin levels were associated with a higher risk of developing RA independently of other factors, including C-reactive protein (CRP) and smoking [hazard ratio (HR) 1.70, 95% confidence interval (CI) 1.12–2.60 for an increase in adiponectin of 10 mg/L, p = 0.01]. After stratifying the population according to adiponectin and CRP median at baseline, study participants with both adiponectin and CRP above the median had a higher risk of developing RA compared to subjects with adiponectin and CRP below the median (HR 2.80, 95% CI 1.25–6.31, p = 0.01). Conclusions In this cohort of subjects with obesity followed up for up to 29 years, high serum adiponectin levels at baseline were associated with an increased risk for RA. Moreover, subjects with both high adiponectin and CRP levels at baseline were at particular risk of developing RA. ClinicalTrials.gov Identifier: NCT01479452.
A medium deep Chandra and Subaru survey of the 13hr XMM/ROSAT deep survey area
Creators: name: McHardy, I. M.
name: Gunn, K. F.
name: Newsam, A. M.
name: Mason, K. O.
name: Page, M. J.
name: Takata, T.
name: Sekiguchi, K.
name: Sasseen, T.
name: Cordova, F.
name: Jones, L. R.
name: Loaring, N.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of a Chandra ACIS-I survey of a high latitude region at 13h +38 which was earlier observed with ROSAT (McHardy et al. 1998) and which has recently been observed by XMM-Newton for 200ksec. XMM-Newton will provide good quality X-ray spectra for over 200 sources with fluxes around the knee of the logN/logS, which are responsible for the bulk of the X-ray background (XRB). The main aim of the Chandra observations is to provide arcsecond, or better, positions, and hence reliable identifications, for the XMM-Newton sources. The ACIS-I observations were arranged in a mosaic of four 30ksec pointings, covering almost all of the 15' radius XMM-Newton/ROSAT field. We detect 214 Chandra sources above 5 sigma significance, to a limiting flux of \~1.3e-15 erg/cm2/s (0.5-7 keV). Optical counterparts are derived from a Subaru SuprimeCam image reaching to R~27. The very large majority of the Chandra sources have an optical counterpart, with the distribution peaking at 23
description: 22 pages, MNRAS in press. A full resolution version is available at http://www.astro.soton.ac.uk/~kfg/catalogue.ps.gz
title: Theory of Growth-Limiting Processes and their Coordination in Proliferating Cells: Quantitative Physiology of the Global Effects on Growth by Transcription, Translation, Protein Degradation and Water Content Increase across E. Coli, S. Cerevisiae, and HeLa Cells
Creators: name: Calabrese, Ludovico
Publisher: name: The Open University
Year: 2025

description: Understanding the determinants of cell growth is a fundamental question in biology. The concept of a growth-limiting factor aids tremendously this goal by positing that growth is constrained by only few molecular components, despite the presence of thousands macromolecules that are essential for growth. Yet, limiting factors change across different environments and inferring what is limiting can be challenging. This challenge arises partly because growth involves coordination of multiple processes, as different biomass components increase simultaneously. Importantly, cells grow both in dry mass and volume, but what ensures coordination remains unanswered. Concurrent dry-mass and volume growth also determine homeostasis of density, an important physiological parameter. Here, leveraging mathematical models and data across different organisms, we investigate how multiple processes affect growth, including protein degradation, translation and transcription, and how dry mass and volume coordinate their growth. First, we find that protein degradation affects growth by requiring a fraction of 'maintenance' ribosomes, revising the estimates of the active-ribosome fraction at slow growth. Second, we explore theoretically how protein degradation helps cell adapt to starvation and find that the degradation rate sets the speed of proteome readjustment, but only up to a threshold. Next, we systematically explore how translation and transcription influence cell growth and find three growth-limitation regimes, two of which include mRNA as a growth-limiting factor. Our model predicts and clarifies important experimental observations, including total mRNA increase across growth conditions and how the growth cost of protein over-expression can be affected by mRNA levels. Finally, using novel joint dry-mass and volume measurements in HeLa cells provided by our collaborators, we show that dry mass and volume are independent at short timescales and coupled at longer timescales and that two independent mechanisms are able to bring back dry-mass density to a desired range, within which cells maintain a strong heterogeneity.
Perceived influence of health status on sexual activity in patients with psoriatic arthritis
Creators: name: G Haugeberg
name: B Michelsen
name: M Østensen
name: A Kavanaugh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To examine the prevalence of self-reported problems with sexual activity among psoriatic arthritis (PsA) patients, and to explore potential associations of such problems with various demographic, musculoskeletal, and dermatological disease variables. Method: Consecutive PsA patients were recruited from an outpatient clinic. Data collected included demographics, measures of musculoskeletal and skin disease activity, and treatments. Perceived effect of health status on sexual activity was assessed using question number 15 from the health-related quality of life instrument 15D; this was explored in univariate and multivariate logistic regression analyses. Results: The study assessed 135 patients (mean age 52.1 years, disease duration 8.7 years, 51.1% male). Mean scores included Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) 2.9, Disease Activity index for PSoriatic Arthritis (DAPSA) 18.2, patient global assessment (PGA) 36.0 mm, pain 33.7 mm, fatigue 45.1 mm, modified Health Assessment Questionnaire (mHAQ) 0.42, Psoriasis Area Severity Index (PASI) 2.5, and Dermatology Life Quality Index (DLQI) 3.4. Twenty-four patients (17.8%) reported that their health status had a large negative effect and 111 (82.2%) that it had no or little effect on their sexual activity. In univariate analyses, a statistically significant association with impaired sexual activity was found for longer disease duration and higher MASES, DAPSA, PGA, fatigue, and mHAQ scores, but not for demographic variables or variables reflecting skin psoriasis involvement (PASI, DLQI). In adjusted analyses, only PsA disease duration remained independently associated with impaired sexual activity. Conclusion: One in five PsA patients perceived that their health status had a negative impact on sexual activity. Disease duration and measures reflecting musculoskeletal involvement, but not measures reflecting skin psoriasis involvement, appeared to be associated with impaired sexual activity.
Additional file of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Creators: name: Ajnakina, Olesya
name: Agbedjro, Deborah
name: McCammon, Ryan
name: Faul, Jessica
name: Murray, Robin M.
name: Stahl, Daniel
name: Steptoe, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: Additional file of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Natural disease progression in finger osteoarthritis: results from a 10 year follow-up cohort
Creators: name: T Vanhaverbeke
name: L Pardaens
name: R Wittoek
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Statistics
subject: FOS: Mathematics

description: Objective: Limited evidence is available about long-term natural disease progression in hand osteoarthritis (HOA). The objective is to study natural radiographic and clinical disease progression in HOA after longer follow-up (i.e. 10 years) and to identify predictors for progression. Method: At baseline (T0), 270 patients with HOA were included in the Belgian HOA register. The majority (84.8%) was female and the mean age was 62.9 years. In total, 154 (57%) and 106 (39.3%) patients consented to follow-up after approximately 5 (T1) and 10 years (T2), respectively. Clinical and functional outcome measures were collected. Hand radiographs were taken and scored according to the anatomical phase scoring system. Results: At T2, most of the patients (73.3%) showed any radiographic progression compared to T0. Remodelling was most frequently seen and new erosive joints rather rarely. Functional Index for Hand Osteoarthritis (0–30) and Australian/Canadian Osteoarthritis Hand Index function (0–90) increased over time, from 8.8 to 9.9 (p = 0.017) and 39.3 to 41.9 (p = 0.035), respectively, after T2. Visual analogue scale pain (0–100) did not change (40.2 to 38.6 from T0 to T2, p = 0.656). Univariate and multivariate logistic regression retained baseline soft-tissue swelling [odds ratio (OR) 8.20 and 8.76, respectively], higher levels of pain (OR 4.08 and 4.30), and number of baseline erosive joints (OR 31.82 and 30.02) as significant predictors for radiographic progression. Conclusions: Significant radiographic progression is seen over time in HOA. While pain remains similar after 10 years, functional status declines. Patients with soft-tissue swelling, high levels of pain, and already erosive disease at baseline are prone to progression over time.
Mono-Stixels: Monocular depth reconstruction of dynamic street scenes
Creators: name: Brickwedde, Fabian
name: Abraham, Steffen
name: Mester, Rudolf
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this paper we present mono-stixels, a compact environment representation specially designed for dynamic street scenes. Mono-stixels are a novel approach to estimate stixels from a monocular camera sequence instead of the traditionally used stereo depth measurements. Our approach jointly infers the depth, motion and semantic information of the dynamic scene as a 1D energy minimization problem based on optical flow estimates, pixel-wise semantic segmentation and camera motion. The optical flow of a stixel is described by a homography. By applying the mono-stixel model the degrees of freedom of a stixel-homography are reduced to only up to two degrees of freedom. Furthermore, we exploit a scene model and semantic information to handle moving objects. In our experiments we use the public available DeepFlow for optical flow estimation and FCN8s for the semantic information as inputs and show on the KITTI 2015 dataset that mono-stixels provide a compact and reliable depth reconstruction of both the static and moving parts of the scene. Thereby, mono-stixels overcome the limitation to static scenes of previous structure-from-motion approaches.
description: 2018 IEEE International Conference on Robotics and Automation (ICRA 2018)
Anti-cyclic citrullinated peptide antibodies are associated with radiographic damage but not disease activity in early rheumatoid arthritis diagnosed in 2006–2011
Creators: name: M Ziegelasch
name: A Boman
name: K Martinsson
name: I Thyberg
name: C Jacobs
name: BM Nyhäll-Wåhlin
name: A Svärd
name: E Berglin
name: S Rantapää-Dahlqvist
name: T Skogh
name: A Kastbom
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Objective: The discovery of anti-citrullinated protein antibodies (ACPAs) and the introduction of new therapeutic options have had profound impacts on early rheumatoid arthritis (RA) care. Since ACPA status, most widely assessed as reactivity to cyclic citrullinated peptides (CCPs), influences treatment decisions in early RA, we aimed to determine whether anti-CCP remains a predictor of disease activity and radiographic joint damage in more recent ‘real-world’ early RA. Method: Two observational early RA cohorts from Sweden enrolled patients in 1996–1999 (TIRA-1, n = 239) and 2006–2009 (TIRA-2, n = 444). Clinical and radiographic data and ongoing treatment were prospectively collected up to 3 years. Two other cohorts served as confirmation cohorts (TRAM-1, with enrolment 1996–2000, n = 249; and TRAM-2, 2006–2011, n = 528). Baseline anti-CCP status was related to disease activity, pharmacotherapy, and radiographic joint damage according to Larsen score. Results: In the TIRA-1 cohort, anti-CCP-positive patients had significantly higher 28-joint Disease Activity Score, swollen joint count, C-reactive protein level, and erythrocyte sedimentation rate during follow-up compared with anti-CCP-negative patients. In TIRA-2, no such differences were found, but baseline anti-CCP positivity was associated with higher 3 year Larsen score (5.4 vs 3.5, p = 0.039). In TRAM-2, anti-CCP also predicted radiographic damage (8.9 vs 6.7, p = 0.027), with no significant differences in disease activity. Conclusion: In the early RA cohorts recruiting patients in 2006–2011, baseline anti-CCP positivity was not associated with disease activity over time, but was associated with increased radiographic damage at follow-up. Hence, close radiographic monitoring is warranted in early anti-CCP-positive RA regardless of disease activity.
Spin Hall magnetoresistance sensor using Au$_x$Pt$_{1-x}$ as the spin-orbit torque biasing layer
Creators: name: Xu, Yanjun
name: Yang, Yumeng
name: Xie, Hang
name: Wu, Yihong
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on investigation of spin Hall magnetoresistance sensor based on NiFe/AuxPt1-x bilayers. Compared to NiFe/Pt, the NiFe/AuxPt1-x sensor exhibits a much lower power consumption (reduced by about 57%), due to 80% enhancement of spin-orbit torque efficiency of AuxPt1-x at an optimum composition of x = 0.19 as compared to pure Pt. The enhanced spin-orbit torque efficiency allows to increase the thickness of NiFe from 1.8 nm to 2.5 nm without significantly increasing the power consumption. We show that, by increasing the NiFe thickness, we were able to improve the working field range (0.86 Oe), operation temperature range (150 degree C) and detectivity (0.71 nT/sqrt(Hz) at 1 Hz) of the sensor, which is important for practical applications.
description: 15 pages, 4 figures
High-Level Networking With Mobile Code And First Order AND-Continuations
Creators: name: Tarau, Paul
name: Dahl, Veronica
Publisher: name: arXiv
Year: 2004
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D.1.6; D.3.2

description: We describe a scheme for moving living code between a set of distributed processes coordinated with unification based Linda operations, and its application to building a comprehensive Logic programming based Internet programming framework. Mobile threads are implemented by capturing first order continuations in a compact data structure sent over the network. Code is fetched lazily from its original base turned into a server as the continuation executes at the remote site. Our code migration techniques, in combination with a dynamic recompilation scheme, ensure that heavily used code moves up smoothly on a speed hierarchy while volatile dynamic code is kept in a quickly updatable form. Among the examples, we describe how to build programmable client and server components (Web servers, in particular) and mobile agents.
description: Appeared in Theory and Practice of Logic Programming, vol. 1, no. 3, 2001
Additional file 1 of Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation
Creators: name: Ajnakina, Olesya
name: Agbedjro, Deborah
name: McCammon, Ryan
name: Faul, Jessica
name: Murray, Robin M.
name: Stahl, Daniel
name: Steptoe, Andrew
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: Additional file 1. Outlines a list of all variables considered in the analyses and whether they have been included or excluded from the model building.