cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Distinguishing Manduca sexta haemocyte types by cytometric methods
Creators: name: Von Bredow, C R
name: Trenczek, T E
Publisher: name: Invertebrate Survival Journal
Year: 2022

description: Manduca sexta larvae possess haemocytes which are classified according to their appearance into five distinct types typical for Lepidoptera: plasmatocytes (PLs), granular cells (GRs), spherule cells (SPs), oenocytoids (OEs), and prohaemocytes (ProHCs). Some haemocytes do not fit morphologically into either class, i.e. sharing morphological criteria of two cell types, obscuring their classification. We characterised larval haemocytes of M. sexta, whose identity was confirmed by specific markers, based on morphometric and cytometric methods by light microscopy and fluorescence microscopy. For each haemocyte class, the size, the length-to-width-ratio, the nuclear morphology, the relative DNA-content and the nucleus-to-cytoplasm-ratio were measured. PLs and GRs occur in either round or spread form, the latter resulting in a high length-to-width-ratio. The shape of the nuclei also differed between haemocyte types, with almost round nuclei in GRs, ProHCs and OEs, and oval to irregularly formed nuclei in SPs and PLs. The nucleus-to-cytoplasm-ratio was shown to differ significantly between each type. PLs and OEs exhibited polyploidy, while granular cells, spherule cells and putative prohaemocytes were presumably 2n (G0/G1) or 4n (G2/M). Finally, a dichotomous guide allowing determination of the haemocyte types by means of light microscopy and DNA labelling was created.
description: Invertebrate Survival Journal, Vol 19 No 1 (2022)
title:  A Tin of Shoe Polish Mostly Used Up
Creators: name: Gerard, Christian Anton
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2009

description: A Tin of Shoe Polish, Mostly Used Up is a collection of poems that explores the author's anxieties concerning his position as a young man, husband, and poet. The collection moves between the author's actual experience and the experience of a fictional older couple in an effort to better understand the human elements of personal growth, connection, and fulfillment.
"I see myself as part of the team" - family caregivers' contribution to safety in advanced home care
Creators: name: Schaepe, Christiane
name: Ewers, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Qualitative research
subject: Family caregivers
subject: Advanced home care
subject: Home mechanical ventilation
subject: Patient safety
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The use of medical technology and the various contributing and interdepending human factors in home care have implications for patient safety. Although family caregivers are often involved in the provision of advanced home care, there is little research on their contribution to safety. The study aims to explore family caregivers in Home Mechanical Ventilation (HMV) safety experiences and how safety is perceived by them in this context. Furthermore, it seeks to understand how family caregivers contribute to the patients' and their own safety in HMV and what kind of support they expect from their health care team. Methods: An explorative, qualitative study was applied using elements from grounded theory methodology. Data were collected through individual interviews with 15 family caregivers to patients receiving HMV in two regions in Germany. The audiotaped interviews were then subject to thematic analysis. Results: The findings shows that family caregivers contribute to safety in HMV by trying to foster mutual information sharing about the patient and his/her situation, coordinating informally health care services and undertaking compensation of shortcomings in HMV. Conclusion: Consequently, family caregivers take on considerable responsibility for patient safety in advanced home care by being actively and constantly committed to safety work. Nurses working in this setting should be clinically and technically skilled and focus on building partnership relations with family caregivers. This especially encompasses negotiation about their role in care and patient safety. Support and education should be offered if needed. Only skilled nurses, who can provide safe care and who can handle critical situations should be appointed to HMV. They should also serve as professional care coordinators and provide educational interventions to strengthen family caregivers' competence.
Feasibility of gadoxetate disodium enhanced 3D T1 MR cholangiography (MRC) with a specific inversion recovery prepulse for the assessment of the hepatobiliary system
Creators: name: Fahlenkamp, Ute Lina
name: Adams, Lisa Christine
name: Böker, Sarah Maria
name: Engel, Günther
name: Huynh Anh, Minh
name: Wagner, Moritz
name: Hamm, Bernd
name: Makowski, Marcus Richard
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: magnetic-resonance cholangiography (MRC)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aim: To compare the potential of a gadoxetate disodium enhanced navigator-triggered 3D T1 magnetic-resonance cholangiography (MRC) sequence with a specific inversion recovery prepulse to T2-weighted MRCP for assessment of the hepatobiliary system. Materials and methods: 30 patients (12 male, 18 female) prospectively underwent conventional navigator-triggered 3D turbo spin-echo T2-weighted MRCP and 3D T1 MRC with a specific inversion pulse to minimise signal from the liver 30 minutes after administration of gadoxetate disodium on a 1.5 T MRI system. For qualitative evaluation, biliary duct depiction was assessed segmentally following a 5-point Likert scale. Visualisation of hilar structures as well as image quality was recorded. Additionally, the extrahepatic bile ducts were assessed quantitatively by calculation of signal-to-noise ratios (SNR). Results: The advantages of T1 3D MRC include reduced affection of image quality by bowel movement and robust depiction of the relative position of the extrahepatic bile ducts in relation to the portal vein and the duodenum compared to T2 MRCP. However, overall T1 3D MRC did not significantly (p > 0.05) improve the biliary duct depiction compared to T2 MRCP in all segments: Common bile duct 4.1 vs. 4.4, right hepatic duct 3.6 vs. 4.2, left hepatic duct 3.5 vs. 4.1. Image quality did not differ significantly (p > 0.05) between both sequences (3.6 vs. 3.5). SNR measurements for the hepatobiliary system did not differ significantly (p > 0.05) between navigator-triggered T1 3D MRC and T2 MRCP. Conclusions: This preliminary study demonstrates that T1 3D MRC of a specific inversion recovery pre-pulse has potential to complement T2 MRCP, especially for the evaluation of liver structures close to the hilum in the diagnostic work-up of the biliary system in patients receiving gadoxetate disodium.
Blueprint CAD Files for Figures 2&3
Creators: name: Mehdipour, Melod
name: Amiri, Payam
name: Liu, Chao
name: DeCastro, Jonalyn
name: Kato, Cameron
name: Skinner, Colin M.
name: Conboy, Michael J.
name: Aran, Kiana
name: Conboy, Irina M.
Publisher: name: figshare
Year: 2022
Subjects: Biological Engineering
Biological Techniques

description: Blueprint files for Figures 2 and 3
Additional file 2 of PEPPRO: quality control and processing of nascent RNA profiling data
Creators: name: Smith, Jason P.
name: Dutta, Arun B.
name: Kizhakke Mattada Sathyan
name: Guertin, Michael J.
name: Sheffield, Nathan C.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 2 Review history.
Tunable quantum interference effect on magnetoconductivity in few-layer black phosphorus
Creators: name: Kim, Sunghoon
name: Min, Hongki
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this study, we develop a systematic weak localization/antilocalization theory fully considering the anisotropy and Berry phase of the system, and apply it to various phases of few-layer black phosphorus (BP), which has a highly anisotropic electronic structure with an electronic gap size tunable even to a negative value. The derivation of a Cooperon ansatz for the Bethe-Salpeter equation in a general anisotropic system is presented, revealing the existence of various quantum interference effects in different phases of few-layer BP, including a crossover from weak localization to antilocalization. We also predict that the magnetoconductivity at the semi-Dirac transition point will exhibit a nontrivial power-law dependence on the magnetic field, while following the conventional logarithmic field-dependence of 2D systems in the insulator and Dirac semimetal phases. Notably, the ratio between the magnetoconductivity and Boltzmann conductivity turns out to be independent of the direction, even in strongly anisotropic systems. Finally, we discuss the tunability of the quantum corrections of few-layer BP in terms of the symmetry class of the system.
description: 16 pages, 4 figures
3-Iodothyronamine activates a set of membrane proteins in murine hypothalamic cell lines
Creators: name: Bräunig, Julia
name: Mergler, Stefan
name: Jyrch, Sabine
name: Hoefig, Carolin S.
name: Rosowski, Mark
name: Mittag, Jens
name: Bieberrnann, Heike
name: Khajavi, Noushafarin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: 3-T(1)AM
subject: signaling
subject: hypothalamus
subject: GPCR
subject: TRP Channel
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: 3-Iodothyronamine (3-T(1)AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T(1)AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to metabolic regulation and thermogenesis. Previous studies identified G protein-coupled receptors (GPCRs) and transient receptor potential channels (TRPs) as targets of 3-T(1)AM in different cell types. These two superfamilies of membrane proteins are largely expressed in tissue which influences energy balance and metabolism. As the first indication that 3-T(1)AM virtually modulates the function of the neurons in hypothalamus, we observed that intraperitoneal administration of 50 mg/kg bodyweight of 3-T(1)AM significantly increased the c-FOS activation in the paraventricular nucleus (PVN) of C57BL/6 mice. To elucidate the underlying mechanism behind this 3-T(1)AM-induced signalosome, we used three different murine hypothalamic cell lines, which are all known to express PVN markers, GT1-7, mHypoE-N39 (N39) and mHypoE-N41 (N41). Various aminergic GPCRs, which are the known targets of 3-T(1)AM, as well as numerous members of TRP channel superfamily, are expressed in these cell lines. Effects of 3-T(1)AM on activation of GPCRs were tested for the two major signaling pathways, the action of G alpha(s)/adenylyl cyclase and G(i/o). Here, we demonstrated that this thyroid hormone metabolite has no significant effect on G(i/o) signaling and only a minor effect on the G alpha(s)/adenylyl cyclase pathway, despite the expression of known GPCR targets of 3-T(1)AM. Next, to test for other potential mechanisms involved in 3-T(1)AM-induced c-FOS activation in PVN, we evaluated the effect of 3-T(1)AM on the intracellular Ca2+ concentration and whole-cell currents. The fluorescence-optic measurements showed a significant increase of intracellular Ca2+ concentration in the three cell lines in the presence of 10 mu M 3-T(1)AM. Furthermore, this thyroid hormone metabolite led to an increase of whole-cell currents in N41 cells. Interestingly, the TRPM8 selective inhibitor (10 mu M AMTB) reduced the 3-T(1)AM stimulatory effects on cytosolic Ca2+ and whole-cell currents. Our results suggest that the profound pharmacological effects of 3-T(1)AM on selected brain nuclei of murine hypothalamus, which are known to be involved in energy metabolism and thermoregulation, might be partially attributable to TRP channel activation in hypothalamic cells.
Zee Model Confronts SNO Data
Creators: name: Frampton, Paul H.
name: Oh, Myoung C.
name: Yoshikawa, Tadashi
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We reexamine the solution of the minimal Zee model by comparing with the data of the SNO experiment, and conclude that the model is strongly disfavored but not yet excluded by the observations. Two extensions of the Zee model are briefly discussed both of which introduce additional freedom and can accommodate the data.
description: 16 pages LaTeX including 7 figures
Aspects of Born-Infeld Theory and String/M-Theory
Creators: name: Gibbons, G W
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: These notes provide a hopefully pedagogic introduction to Born-Infeld theory and some of its uses in String/M-Theory from the perspective of some-one interested in spacetime geometry. Causality and the consequences of having both the open string and closed string metric are stressed. This leads to some new insighst into old problems, such as strings at finite temperature. Various strong coupling limits of both Born-Infeld and the M5-brane theories are described and their relevance for tachyon condensations are mentioned.
description: 29 pages plain Latex. Written version of lectures delivered, amongst other places, at the 37th Karpacz School on Theoretical Physics and the 4th Mexican School on Gravitation and Mathematical Physics
Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus
Creators: name: Munz, Matthias
name: Richter, Gesa M.
name: Loos, Bruno G.
name: Jepsen, Søren
name: Divaris, Kimon
name: Offenbacher, Steven
name: Teumer, Alexander
name: Holtfreter, Birte
name: Kocher, Thomas
name: Bruckmann, Corinna
name: Jockel-Schneider, Yvonne
name: Graetz, Christian
name: Munoz, Loreto
name: Bhandari, Anita
name: Tennstedt, Stephanie
name: Staufenbiel, Ingmar
name: Velde, Nathalie Van Der
name: Uitterlinden, André G.
name: Groot, Lisette C. P. G. M. De
name: Wellmann, Jürgen
name: Berger, Klaus
name: Krone, Bastian
name: Hoffmann, Per
name: Laudes, Matthias
name: Lieb, Wolfgang
name: Franke, Andre
name: Dommisch, Henrik
name: Erdmann, Jeanette
name: Schaefer, Arne S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: coronary artery disease (CAD)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (PAgP-Ger
Mass of the dilaton and the cosmological constant
Creators: name: Fujii, Yasunori
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: One might raise a question if the gravitational scalar field (dilaton) mediates a finite-range force between local objects still behaving globally as being massless to implement the scenario of a decaying cosmological constant. We offer a non-negative reply by a detailed analysis of the field-theoretical quantization procedure in relation to the observationally required suppression of the vacuum-energy.
description: 9 pages LaTeX 1 figure; an added reference and partial revisions
Additional file 1 of Examining primary care physician rationale for not following geriatric choosing wisely recommendations
Creators: name: Rowe, Theresa A.
name: Brown, Tiffany
name: Doctor, Jason N.
name: Linder, Jeffrey A.
name: Persell, Stephen D.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1
Muscle Atrophy Due to Nerve Damage Is Accompanied by Elevated Myofibrillar Protein Synthesis Rates
Creators: name: Langer, Henning T.
name: Senden, Joan M. G.
name: Gijsen, Annemie P.
name: Kempa, Stefan
name: Van Loon, Luc J. C.
name: Spuler, Simone
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: skeletal muscle
subject: atrophy
subject: muscle loss
subject: myofibrillar
subject: protein synthesis
subject: nerve damage
subject: stable isotope
subject: deuterium oxide
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Muscle loss is a severe complication of many medical conditions such as cancer, cardiac failure, muscular dystrophies, and nerve damage. The contribution of myofibrillar protein synthesis (MPS) to the loss of muscle mass after nerve damage is not clear. Using deuterium oxide (D2O) labeling, we demonstrate that MPS is significantly increased in rat m. tibialis anterior (TA) compared to control (3.23 +/- 0.72 [damaged] to 2.09 +/- 0.26%*day(-1) [control]) after 4 weeks of nerve constriction injury. This is the case despite substantial loss of mass of the TA (350 +/- 96 mg [damaged] to 946 +/- 361 mg [control]). We also show that expression of regulatory proteins involved with MPS (p70s6k1: 2.4 +/- 0.3 AU [damaged] to 1.8 +/- 0.2 AU [control]) and muscle protein breakdown (MPB) (MAFbx: 5.3 +/- 1.2 AU [damaged] to 1.4 +/- 0.4 AU [control]) are increased in nerve damaged muscle. Furthermore, the expression of p70s6k1 correlates with MPS rates (r(2) = 0.57). In conclusion, this study shows that severe muscle wasting following nerve damage is accompanied by increased as opposed to decreased MPS.
Complete eigenstates of identical qubits arranged in regular polygons
Creators: name: Rudolph, Terry
name: Yavin, Itay
name: Freedhoff, Helen
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We calculate the energy eigenvalues and eigenstates corresponding to coherent single and multiple excitations of an array of N identical qubits or two-level atoms (TLA's) arranged on the vertices of a regular polygon. We assume only that the coupling occurs via an exchange interaction which depends on the separation between the qubits. We include the interactions between all pairs of qubits, and our results are valid for arbitrary distances relative to the radiation wavelength. To illustrate the usefulness of these states, we plot the distance dependence of the decay rates of the n=2 (biexciton) eigenstates of an array of 4 qubits, and tabulate the biexciton eigenvalues and eigenstates, and absorption frequencies, line widths, and relative intensities for polygons consisting of N=2,...,9 qubits in the long-wavelength limit.
description: Added a figure showing how these results can be used to compute deviations from "equal collective decoherence" approximations
Oral propranolol for prevention of threshold retinopathy of prematurity (ROPROP): protocol of a randomised controlled trial
Creators: name: Bührer, Christoph
name: Erdeve, Ömer
name: Bassler, Dirk
name: Bar-Oz, Benjamin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Propranolol
subject: Retinopathy Of Prematurity
subject: Repurposing
subject: Randomized Controlled Trial
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction Retinopathy of prematurity (ROP) is a disease observed in extremely premature infants characterised by visioning-threatening retinal vessel proliferation. Propranolol, a drug used for decades in newborn infants with heart diseases, hypertension and thyrotoxicosis and licenced for infantile haemangiomas, may be effective in halting progression of ROP to severe stages, as suggested by preliminary data from small studies. Methods and analysis ROPROP is an investigator-initiated, multicentre, placebo-controlled double-blind, randomised controlled trial aiming to assess the safety and efficacy of orally administered propranolol to reduce the risk of threshold ROP (stage 3) in extremely preterm infants at 48 weeks postmenstrual age (primary objective) and the rate of infants requiring local interventions for severe ROP (secondary objective). Key inclusion criteria: gestational age <28 weeks, birth weight <1250g, postmenstrual age >= 31 and <37 weeks, incipient ROP (stage 1 or 2, with or without plus disease) and written informed consent by parents or legal guardian. Key exclusion criteria: requirement for open-label propranolol treatment, major congenital malformations (including those with cerebrovascular malformations), known chromosomal anomalies, colobomas and other eye malformations, atrioventricular block grade 2 or 3 and comedication with antiarrhythmics, clonidine, insulin (pharmacodynamic interaction), phenobarbital or rifampicin (pharmacokinetic interaction). The intervention consists of oral propranolol-hydrochloride (1.6 mg/kg/day in three to four divided dosages) or placebo until discharge, for a maximum of 10 weeks. Analysis is by intention to treat. Ethics and dissemination The protocol has received ethical and regulatory approval. Results will be published after peer review irrespective of the study outcome.
Immigration, integration and ghetto formation
Creators: name: Meyer-Ortmanns, Hildegard
Publisher: name: arXiv
Year: 2002
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We study ghetto formation in a population with natives and immigrants in the framework of the two-dimensional Ising-model with Kawasaki-exchange dynamics. It is the phase structure of the Ising model, the integration speed and the immigration rate which determine whether ghetto formation between natives and immigrants can be avoided or not. Our simulations are performed in and out-of equilibrium.
description: 10 pages, LaTeX2e, 16 postscript figures, to be published in Int.J.Mod.Phys.C14,no.3,2003
miR-9-5p in Nephrectomy Specimens is a Potential Predictor of Primary Resistance to First-Line Treatment with Tyrosine Kinase Inhibitors in Patients with Metastatic Renal Cell Carcinoma
Creators: name: Ralla, Bernhard
name: Busch, Jonas
name: Flörcken, Anne
name: Westermann, Jörg
name: Zhao, Zhongwei
name: Kilic, Ergin
name: Weickmann, Sabine
name: Jung, Monika
name: Fendler, Annika
name: Jung, Klaus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: renal cell carcinoma
subject: metastasis
subject: tyrosine kinase inhibitors
subject: sunitinib
subject: primary resistance
subject: microRNAs
subject: prognostic indicator
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Approximately 20-30% of patients with metastatic renal cell carcinoma (mRCC) in first-line treatment with tyrosine kinase inhibitors (TKIs) do not respond due to primary resistance to this drug. At present, suitable robust biomarkers for prediction of a response are not available. Therefore, the aim of this study was to evaluate a panel of microRNAs (miRNAs) in nephrectomy specimens for use as predictive biomarkers for TKI resistance. Archived formalin-fixed, paraffin embedded nephrectomy samples from 60 mRCC patients treated with first-line TKIs (sunitinib, n = 51; pazopanib, n = 6; sorafenib, n = 3) were categorized into responders and non-responders. Using the standard Response Evaluation Criteria in Solid Tumors, patients with progressive disease within 3 months after the start of treatment with TKI were considered as non-responders and those patients with stable disease and complete or partial response under the TKI treatment for at least 6 months as responders. Based on a miRNA microarray expression profile in the two stratified groups of patients, seven differentially expressed miRNAs were validated using droplet digital reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) assays in the two groups. Receiver operating characteristic curve analysis and binary logistic regression of response prediction were performed. MiR-9-5p and miR-489-3p were able to discriminate between the two groups. MiR-9-5p, as the most significant miRNA, improved the correct prediction of primary resistance against TKIs in comparison to that of conventional clinicopathological variables. The results of the decision curve analyses, Kaplan-Meier analyses and Cox regression analyses confirmed the potential of miR-9-5p in the prediction of response to TKIs and the prediction of progression-free survival after the initiation of TKI treatment.
Effect of water temperature on the behavior of Neptunea cumingii and the histology, immune enzyme activity, and transcriptome of its gills and kidneys
Creators: name: Zhang, D
name: Dong, X
name: Zhu, J
name: Yang, J
name: Tian, Y
name: Wang, L
name: Mao, J
name: Wang, X
name: Chang, Y
name: Hao, Z
Publisher: name: Invertebrate Survival Journal
Year: 2022

description: The behavior of the marine snail Neptunea cumingii cultured at different temperatures (0, 4, 8, 12, 16 (control), 20, 24, and 28 °C) and the histology, immune enzyme activity, and transcriptome of its gills and kidneys were studied using ecological and molecular methods. At 0 °C, most of the snails shrank in size and did not eat during the first 6 h. At 28 °C, snails also did not eat, death began to occur at 24 h. The histology of the gills and kidneys differed among test temperatures. At 0 °C, the morphology of the gill pieces was difficult to judge. At 24 °C, edema was present in the gill lamella, and at 28 °C the gill lamella were severely deformed. Temperature increase or decrease from 16 °C caused the columnar cells of the kidney to become shorter and more numerous. The total antioxidant capacity (T-AOC), catalase (CAT) and superoxide dismutase activities (SOD) of the gill and kidney differed significantly among the temperature conditions (p < 0.05). The DEGs were subject to GO and KEGG enrichment analysis, and which showed that most of the DEGs in gill were involved in protein folding, defolding, translation, ribosome, and most of the DEGs in kidney were involved in DNA recombination, nuclear euchromatin, RNA-directed DNA polymerase activity. Finally, the results from this study showed that N. cumingii prefers the temperature range was 8 to 16 °C.
description: Invertebrate Survival Journal, Vol 19 No 1 (2022)
Causal Poisson Brackets of the SL(2,R) WZNW Model and its Coset Theories
Creators: name: Ford, C.
name: Jorjadze, G.
name: Weigt, G.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: From the basic chiral and anti-chiral Poisson bracket algebra of the SL(2,R) WZNW model, non-equal time Poisson brackets are derived. Through Hamiltonian reduction we deduce the corresponding brackets for its coset theories.
description: 7 pages, LaTeX, no figures
Do statins improve outcomes for patients with non-small cell lung cancer? A systematic review and meta-analysis protocol
Creators: name: Li, Feng
name: Liu, Guangyu
name: Roudi, Raheleh
name: Huang, Qi
name: Swierzy, Marc
name: Ismail, Mahmoud
name: Zhao, Song
name: Rueckert, Jens-Carsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: non-small-cell lung cancer
subject: prognostic effects
subject: statins
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction Lung cancer is the most common neoplasm and the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC), accounting for 85% of all lung cancer cases, is frequently diagnosed at an advanced and metastatic stage. In addition, survival of patients with NSCLC has not improved significantly over the recent decades. Statins are used as a cholesterol-lowering agent, but recently preclinical and clinical studies have revealed their anticancer effects. Thus, this systematic review and meta-analysis aims to clarify whether statins improve the prognosis of patients with NSCLC. Methods and analysis We will search MEDLINE (PubMed), EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials and ClinicalTrials.gov with no restriction on language. Both randomised controlled trials (RCTs) and observational cohort studies evaluating the prognostic role of statins in patients with NSCLC will be included. The primary outcome will be overall survival, and the secondary outcomes will include cancer-specific survival, disease-free survival and cancer recurrence. Two assessors will assess the RCTs using the Cochrane Collaboration's risk of bias tool and the observational cohort studies according to ROBINS-I. Publication bias will be assessed by funnel plot using the STATA software v.13.1. Ethics and dissemination No ethical issues are predicted. This systematic review and meta-analysis aims to describe the prognostic effects of statins in patients with NSCLC, which would help clinicians to optimise treatment for patients with NSCLC. These findings will be published in a peer-reviewed journal and presented at national and international conferences. PROSPERO registration number CRD42016047524.
Social Entrepreneurship: Gender, Family and Social Relationships in India
Creators: name: Khurshid, Sadaf
Publisher: name: University of Wollongong
Year: 2025
Subjects: classificationCode: 3503
subject: Business systems in context
classificationCode: 4405
subject: Gender studies
classificationCode: 4702
subject: Cultural studies

description: This thesis explores the familial dynamics that shape the experiences of female social entrepreneurs in Delhi, India. It explores the enabling and inhibiting relationships within their families and examines how familial capital transformations influence their entrepreneurial journey.Employing a qualitative approach, this study delves into the familial relations that serve as pivotal factors in the lives of female social entrepreneurs. Through semi-structured interviews with fifteen female social entrepreneurs, critical discourse analysis is utilised to analyse the data.Female social entrepreneurs leverage familial capital to attain cultural, economic, and social capital, fostering their personal growth. The study indicates the transfer of social capital and its critical role in human capital development. With enhanced social capital, female social entrepreneurs pursue financial independence, benefiting both themselves and their communities. Interestingly, many married female entrepreneurs receive support from their mothers-in-law, possibly due to augmented symbolic capital. Despite their financial autonomy, female entrepreneurs seek financial advice from fathers or husbands.Patriarchal traditions exhibit signs of weakening, with female entrepreneurs actively participating in household decision-making and challenging societal expectations. Elderly parents find acceptance in daughters' households, while women prioritise education over societal norms, recognizing its significance in elevating social status and achieving financial security.This thesis sheds light on the transformative role of familial relationships in empowering female social entrepreneurs and underscores the evolving cultural landscape propelling their success in India. This research contributes to expanding the body of knowledge pertaining to female social entrepreneurs in India. It also gives an understanding of the weakening of patriarchy pertaining to the middle class households in Delhi, India.
The physical graviton two-point function in de Sitter spacetime with S^3 spatial sections
Creators: name: Higuchi, Atsushi
name: Weeks, Richard H.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the physical graviton two-point function in de Sitter spacetime with three-sphere spatial sections. We demonstrate that the large-distance growth present in the corresponding two-point function in spatially flat de Sitter spacetime is absent. We verify that our two-point function agrees with that in Minkowski spacetime in the zero cosmological constant limit.
description: 21 pages, LaTeX, minor errors concerning factors of H corrected
Limb skin temperature as a tool to predict orthostatic instability
Creators: name: Opatz, Oliver
name: Nordine, Michael
name: Habazettl, Helmut
name: Ganse, Bergita
name: Petricek, Jan
name: Dosel, Petr
name: Stahn, Alexander
name: Steinach, Mathias
name: Gunga, Hanns-Christian
name: Maggioni, Martina A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: lower body negative pressure
subject: skin temperature
subject: blood pooling
subject: acceleration
subject: orthostatic hypotension
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Orthostatic instability is one of the main consequences of weightlessness or gravity challenge and plays as well a crucial role in public health, being one of the most frequent disease of aging. Therefore, the assessment of effective countermeasures, or even the possibility to predict, and thus prevent orthostatic instability is of great importance. Heat stress affects orthostatic stability and may lead to impaired consciousness and decrease in cerebral perfusion, specifically during the exposure to G-forces. Conversely, peripheral cooling can prevent orthostatic intolerance - even in normothermic healthy subjects. Indicators of peripheral vasodilation, as elevated skin surface temperatures, may mirror blood decentralization and an increased risk of orthostatic instability. Therefore, the aim of this study was to quantify orthostatic instability risk, by assessing in 20 fighter jet pilot candidates' cutaneous limb temperatures, with respect to the occurrence of G-force-induced almost loss of consciousness (ALOC), before and during exposure to a push-pull maneuver, i.e., head-down tilt, combined with lower body negative pressure. Peripheral skin temperatures from the upper and lower (both proximal and distal) extremities and core body temperature via heat-flux approach (i.e., the Double Sensor), were continuously measured before and during the maneuver. The 55% of subjects that suffered an ALOC during the procedure had higher upper arm and thigh temperatures at baseline compared to the 45% that remained stable. No difference in baseline core body temperature and distal limbs (both upper and lower) skin temperatures were found between the two groups. Therefore, peripheral skin temperature data could be considered a predicting factor for ALOC, prior to rapid onset acceleration. Moreover, these findings could also find applications in patient care settings such as in intensive care units.
Prediction is a balancing act: importance of sampling methods to balance sensitivity and specificity of predictive models based on imbalanced chemical data sets
Creators: name: Banerjee, Priyanka
name: Dehnbostel, Frederic O.
name: Preissner, Robert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: machine learning
subject: DILI
subject: sampling methods
subject: Tox21
subject: imbalanced data
subject: molecular fingerprints
subject: sensitivity-specificity balance
subject: SMOTE
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Increase in the number of new chemicals synthesized in past decades has resulted in constant growth in the development and application of computational models for prediction of activity as well as safety profiles of the chemicals. Most of the time, such computational models and its application must deal with imbalanced chemical data. It is indeed a challenge to construct a classifier using imbalanced data set. In this study, we analyzed and validated the importance of different sampling methods over non-sampling method, to achieve a well-balanced sensitivity and specificity of a machine learning model trained on imbalanced chemical data. Additionally, this study has achieved an accuracy of 93.00%, an AUC of 0.94, F1 measure of 0.90, sensitivity of 96.00% and specificity of 91.00% using SMOTE sampling and Random Forest classifier for the prediction of Drug Induced Liver Injury (DILI). Our results suggest that, irrespective of data set used, sampling methods can have major influence on reducing the gap between sensitivity and specificity of a model. This study demonstrates the efficacy of different sampling methods for class imbalanced problem using binary chemical data sets.
Topological damping Rashba spin orbit torque in ballistic magnetic domain walls
Creators: name: Wang, D.
name: Zhou, Yan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Rashba spin orbit torque derived from the broken inversion symmetry at ferromagnet/heavy metal interfaces has potential application in spintronic devices. In conventional description of the precessional and damping components of the Rashba spin orbit torque in magnetization textures, the decomposition coefficients are assumed to be independent of the topology of the underlying structure. Contrary to this common wisdom, for Schrödinger electrons trespassing ballistically across a magnetic domain wall, we found that the decomposition coefficient of the damping component is determined by the topology of the domain wall. The resultant damping Rashba spin orbit torque is protected by the topology of the underlying magnetic domain wall and robust against small deviations from the ideal domain wall profile. Our identification of a topological damping Rashba spin orbit torque component in magnetic domain walls will help to understand experiments on current driven domain wall motion in ferromagnet/heavy metal systems with broken inversion symmetry and to facilitate its utilization in innovative device designs.
description: 12 pages, 3 figures
Theory of CP Violation in the B-Meson System
Creators: name: Neubert, Matthias
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent developments in the theory of CP violation in the B-meson system are reviewed, with focus on the determination of sin(2beta) from B-> J/psi K decays, its implications for tests of the Standard Model and searches for New Physics, and the determination of gamma and alpha from charmless hadronic B decays.
description: Invited plenary talk given at the 10th International Symposium on Lepton and Photon Interactions at High Energies (Rome, Italy, 23-28 July 2001), 15 pages, 8 figures
Numerical relativity simulation of GW150914 beyond general relativity
Creators: name: Okounkova, Maria
name: Stein, Leo C.
name: Moxon, Jordan
name: Scheel, Mark A.
name: Teukolsky, Saul A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We produce the first astrophysically-relevant numerical binary black hole gravitational waveform in a higher-curvature theory of gravity beyond general relativity. We simulate a system with parameters consistent with GW150914, the first LIGO detection, in order-reduced dynamical Chern-Simons gravity, a theory with motivations in string theory and loop quantum gravity. We present results for the leading-order corrections to the merger and ringdown waveforms, as well as the ringdown quasi-normal mode spectrum. We estimate that such corrections may be discriminated in detections with signal to noise ratio $\gtrsim 180-240$, with the precise value depending on the dimension of the GR waveform family used in data analysis.
description: 7 pages + appendices, 8 figures, Updated to match Phys. D. Rev article
Additional file 2 of Examining primary care physician rationale for not following geriatric choosing wisely recommendations
Creators: name: Rowe, Theresa A.
name: Brown, Tiffany
name: Doctor, Jason N.
name: Linder, Jeffrey A.
name: Persell, Stephen D.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2
RXFP1 receptor activation by relaxin-2 induces vascular relaxation in mice via a Gαi2-protein/PI3Kß/γ/nitric oxide-coupled pathway
Creators: name: Lian, Xiaoming
name: Beer-Hammer, Sandra
name: König, Gabriele M.
name: Kostenis, Evi
name: Nürnberg, Bernd
name: Gollasch, Maik
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: serelaxin
subject: relaxin-2
subject: endothelial G alpha(i2)
subject: NO
subject: RXFP1 receptor
subject: perivascular-adipose tissue
subject: ADRF
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Relaxins are small peptide hormones, which are novel candidate molecules that play important roles in cardiometablic syndrome. Relaxins are structurally related to the insulin hormone superfamily, which provide vasodilatory effects by activation of G-protein-coupled relaxin receptors (RXFPs) and stimulation of endogenous nitric oxide (NO) generation. Recently, relaxin could be demonstrated to activate G(i) proteins and phosphoinositide 3-kinase (PI3K) pathways in cultured endothelial cells in vitro. However, the contribution of the G(i)-PI3K pathway and their individual components in relaxin-dependent relaxation of intact arteries remains elusive. Methods: We used G alpha(i2)- (Gnai2(-/-)) and G alpha(i3)-deficient (Gnai3(-/-)) mice, pharmacological tools and wire myography to study G-protein-coupled signaling pathways involved in relaxation of mouse isolated mesenteric arteries by relaxins. Human relaxin-1, relaxin-2, and relaxin-3 were tested. Results: Relaxin-2 (similar to 50% relaxation at 10(-11) M) was the most potent vasodilatory relaxin in mouse mesenteric arteries, compared to relaxin-1 and relaxin-3. The vasodilatory effects of relaxin-2 were inhibited by removal of the endothelium or treatment of the vessels with N (G)-nitro-L-arginine methyl ester (L-NAME, endothelial nitric oxide synthase (eNOS) inhibitor) or simazine (RXFP1 inhibitor). The vasodilatory effects of relaxin-2 were absent in arteries of mice treated with pertussis toxin (PTX). They were also absent in arteries isolated from Gnai2(-/-) mice, but not from Gnai3(-/-) mice. The effects were not affected by FR900359 (G alpha(q) protein inhibitor) or PI-103 (PI3K alpha inhibitor), but inhibited by TGX-221 (PI3K beta inhibitor) or AS-252424 (PI3K gamma inhibitor). Simazine did not influence the anti-contractile effect of perivascular adipose tissue. Conclusion: Our data indicate that relaxin-2 produces endothelium- and NO-dependent relaxation of mouse mesenteric arteries by activation of RXFP1 coupled to G(i2)-PI3K-eNOS pathway. Targeting vasodilatory G(i)-protein-coupled RXFP1 pathways may provide promising opportunities for drug discovery in endothelial dysfunction and cardiometabolic disease.
Adaptive Organoid Intelligence System for Ethical AI Decision-Making
Creators: name: Assenza, Nicole
Publisher: name: Zenodo
Year: 2025

description: Description:This document establishes prior art for an Adaptive Organoid Intelligence System, integrating biologically inspired computational networks with artificial intelligence (AI) for ethical decision-making applications. This system combines neuronal organoid networks, multi-electrode arrays (MEAs), reinforcement learning models, and ethical decision frameworks to create an AI architecture capable of self-modifying and evolving its decision-making processes in real time.

The purpose of this publication is to prevent unauthorized patenting of this concept by publicly disclosing key methodologies while maintaining non-enabling descriptions to avoid easy replication. This research is relevant to AI ethics, neuromorphic computing, autonomous decision-making, brain-computer interfaces (BCIs), and cybersecurity.

Keywords:Prior Art, AI Ethics, Organoid Computing, Defensive Publication, Neuromorphic AI, Ethical Decision-Making
D-instanton probes of N=2 non-conformal geometries
Creators: name: Fucito, Francesco
name: Morales, Jose F.
name: Tanzini, Alessandro
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: D-instanton calculus has proved to be able to probe the AdS near horizon geometry for $N$ D-branes systems which, when decoupled from gravity, yield four dimensional superconformal gauge theories with various matter content. In this work we extend previous analysis to encompass fractional brane models which give rise to non conformal N=2 Super Yang-Mills theories. Via D-instanton calculus we study the geometry of such models for finite $N$ and recover the $β$ function of the gauge coupling constants which is expected in non conformal gauge theories. We also give a topological matrix theory formulation for the D-instanton action of these theories. Finally, we revisit the related system where the D3-branes wrap a ${\real}^4/{\zet}_p$ orbifold singularity and the D(-1) branes are associated to instanton solutions of four-dimensional gauge theories in the blown down ALE space.
description: latex file, 26 pages no figures
Two-dimensional magnetic semiconductors with room Curie temperatures
Creators: name: You, Jing-Yang
name: Zhang, Zhen
name: Dong, Xue-Juan
name: Gu, Bo
name: Su, Gang
Publisher: name: arXiv
Year: 2019
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We propose two-dimensional (2D) Ising-type ferromagnetic semiconductors TcSiTe3, TcGeSe3, and TcGeTe3 with high Curie temperatures around 200-0500 K. Owing to large spin-orbit couplings, the large magnetocrystalline anisotropy energy (MAE), large anomalous Hall conductivity, and large magneto-optical Kerr effect were discovered in these intriguing 2D materials. By comparing all possible 2D MGeTe3 materials (M = 3d, 4d, 5d transition metals), we found a large orbital moment around 0.5 $μ$B per atom and a large MAE for TcGeTe3. The large orbital moments are revealed to be from the comparable crystal fields and electron correlations in these Tc-based 2D materials. The microscopic mechanism of the high Curie temperature is also addressed. Our findings reveal the unique magnetic behaviors of 2D Tc-based materials and present a family of 2D ferromagnetic semiconductors with large MAE and Kerr rotation angles that would have wide applications in designing spintronic devices.