cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors
Creators: name: Hassab, Mahmoud A. El
name: Eldehna, Wagdy M.
name: Al-Rashood, Sara T.
name: Alharbi, Amal
name: Eskandrani, Razan O.
name: Alkahtani, Hamad M.
name: Elkaeed, Eslam B.
name: Abou-Seri, Sahar M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme was exploited as a promising target to identify a novel potential inhibitor using multi-stage structure-based drug discovery approaches. Firstly, a 3D pharmacophore was generated based on the collected data from a protein-ligand interaction fingerprint (PLIF) study using key interactions between co-crystallised fragments and the NSP13 helicase active site. The ZINC database was screened through the generated 3D-pharmacophore retrieving 13 potential hits. All the retrieved hits exceeded the benchmark score of the co-crystallised fragments at the molecular docking step and the best five-hit compounds were selected for further analysis. Finally, a combination between molecular dynamics simulations and MM-PBSA based binding free energy calculations was conducted on the best hit (compound FWM-1) bound to NSP13 helicase enzyme, which identified FWM-1 as a potential potent NSP13 helicase inhibitor with binding free energy equals −328.6 ± 9.2 kcal/mol.
title: Grab- oder Weihrelief? Klassisch oder klassizistisch? Überlegungen zu einem Relief der Sammlung Odelschalchi in La Granja de San Ildefonso
title: Grab- oder Weihrelief? Klassisch oder klassizistisch? Überlegungen zu einem Relief der Sammlung Odelschalchi in La Granja de San Ildefonso
titleType: Subtitle
Creators: name: Trunk, Markus
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Sarkophage
subject: Reliefsarkophage

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
title: Why La Rasa was not a Camp of the Scipionic Siege of Numantia
title: Why La Rasa was not a Camp of the Scipionic Siege of Numantia
titleType: Subtitle
Creators: name: Morales Hernández, Fernando
name: Dobson, Mike
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Numantia
subject: La Rasa
subject: Numantia
subject: La Rasa
subject: Numancia
subject: La Rasa

description: Madrider Mitteilungen, Vol. 46 (2005)
description: In dieser kurzen Arbeit wird das Lager von La Rasa untersucht, einer der sieben Stützpunkte während der Belagerung Numantias, die Schulten 1909 entdeckt und teilweise ausgegraben hat. Die vielzähligen Aspekte, in denen es sich von den restlichen Lagern und Befestigungen unterscheidet, welche die scipionen-zeitliche Umwallung bildeten (Erscheinungsbild, wenig Fundmaterial, Fehlen der Innenbebauung, Fehlen von Resten des vallum), legen nahe, dass das Lager von La Rasa aus dem scipionen-zeitlichen Kontext ausgeschlossen werden muss und vielmehr in einen früheren Moment in Zusammenhang mit dem Krieg von Numatia zu setzen ist. Der kürzlich getätigte Fund von Materialien zwischen Peña Redonda und Molino, nahe des Flusslaufes des Río Merdancho, bestätigt zweifellos diese formulierte These.
Textos Juma / Juma texts
Creators: name: Juma, Borea
name: Juma, Mandei
name: Uru-Eu-Wau-Wau, Awip
name: Dos Santos, Wesley
Publisher: name: California Language Archive, University of California, Berkeley
Year: 2025
Subjects: subject: urz
subject: jua

description: 17 arquivos de áudio e 25 vídeos. A estrutura do rótulo do arquivo é jua_initial-falante_data_inicial-de-quem-gravou_número_tipo.wav. mju = Mandei Juma, bor = Boreá Juma, dur = Davi (Awip) Uru Eu Wau Wau, wns = Wesley dos Santos.

--------------------

17 audio and 25 video recordings. The file name structure consists of urz_consultant-initial_date_recorder's-initial_number_type.wav. mju = Mandei Juma, bor = Boreá Juma, dur = Davi (Awip) Uru Eu Wau Wau, wns = Wesley dos Santos.
Cable equation for general geometry
Creators: name: López-Sánchez, Erick J.
name: Romero, Juan M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: The cable equation describes the voltage in a straight cylindrical cable, this model has been employed to model electrical potential in dendrites and axons. However, sometimes this equation might give incorrect predictions for some realistic geometries, in particular when the radius of the cable changes significantly. Cables with a non constant radius are important for some phenomena, for example discrete swellings along the axons appear in neurodegenerative diseases such as Alzheimer, Parkinson, HIV-associated dementia and Multiple Sclerosis. In this paper, using the Frenet-Serret frame, we propose a generalized cable equation for a general cable geometry. This generalized equation depends on geometric quantities such as the curvature and torsion of the cable. We show that when the cable has a constant circular cross-section, the first fundamental form of the cable can be simplified and the generalized cable equation depends on neither the curvature nor the torsion of the cable. Additionally, we find an exact solution for an ideal cable which has a particular variable circular cross-section and zero curvature. For this case we show that when the cross-section of the cable increases the voltage decreases. Inspired in this ideal case, we rewrite the generalized cable equation as a diffusion equation with a source term generated by the cable geometry. This source term depends on the cable cross-section area and its derivates. In addition, we study different cables with swelling and provide their numerical solutions. The numerical solutions show that when the cross-section of the cable has abrupt changes, its voltage is smaller than the voltage in the cylindrical cable. Furthermore, these numerical solutions show that the voltage can be affected by geometrical inhomogeneities on the cable.
description: 13 page, 7 figures
title: Anse de simpulum (louche) à tête de canidé (Inv. 2006.39.120.1) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: louche

description: Le simpulum est une louche romaine à long manche qui sert à puiser du vin dans un cratère. Il peut être suspendu sur les bords du cratère par son extrémité recourbée en crochet  dont nous avons ici un bel exemple avec cette tête de canidé finement travaillée dans les moindres détails : babines rehaussées de traits gravés  dents poinçonnées  pelage figuré par des stries incisées…
LSB Matching Steganalysis Based on Patterns of Pixel Differences and Random Embedding
Creators: name: Lerch-Hostalot, Daniel
name: Megías, David
Publisher: name: arXiv
Year: 2017
Subjects: subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: This paper presents a novel method for detection of LSB matching steganogra- phy in grayscale images. This method is based on the analysis of the differences between neighboring pixels before and after random data embedding. In natu- ral images, there is a strong correlation between adjacent pixels. This correla- tion is disturbed by LSB matching generating new types of correlations. The pre- sented method generates patterns from these correlations and analyzes their varia- tion when random data are hidden. The experiments performed for two different image databases show that the method yields better classification accuracy com- pared to prior art for both LSB matching and HUGO steganography. In addition, although the method is designed for the spatial domain, some experiments show its applicability also for detecting JPEG steganography.
Family Burden and Social Support in Mental Illness: A Comparative Study in Schizophrenia and Mood Disorders
Creators: name: JOSY KADAVIL THOMAS
Publisher: name: Monash University
Year: 2018
Subjects: subject: 160701 Clinical Social Work Practice
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The present study was an attempt to assess and compare the global functioning of individuals affected with two major mental illnesses i.e. schizophrenia and mood disorders , social support perceived by them, and family burden and social support perceived by their caregivers. The individuals affected with schizophrenia were found to be more severely ill with a longer duration of illness, and perceived less social support as compared to those with mood disorders. The caregivers’ perceived social support was similar in both diagnostic groups. Family burden was significantly higher in the schizophrenia group. Some significant correlations were found among the key study variables.
title: Anse de simpulum (louche) à tête de canidé (Inv. 2006.39.120.1)
Creators: name: Cauuet, Béatrice
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: louche
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
title: Una aproximación a las cuevas-santuario ibéricas en el País Valenciano
title: Una aproximación a las cuevas-santuario ibéricas en el País Valenciano
titleType: Subtitle
Creators: name: González Alcalde, Julio
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Valencia
subject: ibersiche Höhlenheiligtümer
subject: Valencia
subject: iberian cave santuaries
subject: Valencia
subject: cuevas-santuario ibéricas

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Im Bereich der Iberischen Kultur wurden unterirdische Komplexe, sog. Höhlenheiligtümer aus der Zeit zwischen dem 6. Jh. v. Chr. und dem Beginn der Romanisierung dokumentiert. Der vorliegende Beitrag bezieht sich dabei auf Höhlen des ‘País Valenciano’. Die Höhlen liegen in bergigen Zonen. Ihre geologische Entstehung geht, von Ausnahmen abgesehen, auf karstische Prozesse zurück, wobei das Wasser gefährliche labyrinthische Gänge ausgewaschen hat. In diesen Höhlungen deponierte man im wesentlichen keramisches und metallisches Material und gelegentlich in den tiefsten Teilen, manchmal mit Wasser verbunden, in Stalagmiten oder in Löchern der felsigen Wände. Unter den Funden fallen die kelchförmigen Gefäße auf, die mit dem Kult verbunden werden – sie wurden absichtlich zerbrochen bzw. mit der Gefäßmündung zuunterst deponiert –, daneben Kalathoi, Schalen, Deckel, Becher, Krüge, Teller, Platten, Webgewichte, Metallgegenstände wie Ringe, Sigelringe, Armreifen, Fibeln, Schnallen, geschweifte Messer, Dolche und Münzen. Außerdem wird attische Keramik dokumentiert. Aus diesen Höhlen stammt zudem römisches Material, das deren Weiterbenutzung bis in römische Zeit belegt. Auf Grund der geographischen Lage und der Gestalt der Höhlen, der Fundkontexte und der mediterranen Vergleiche können diese Höhlenheiligtümer unter anderen mit Riten des Überganges und Initiationsriten kriegerischer Altenverbänden, priesterlicher und spiritueller Gemeinschaften verbunden werden.
LysR-type transcriptional regulator OvrB encoded in O island 9 drives enterohemorrhagic Escherichia coli O157:H7 virulence
Creators: name: Liu, Yutao
name: Liu, Bin
name: Yang, Pan
name: Wang, Ting
name: Chang, Zhanhe
name: Wang, Junyue
name: Wang, Qian
name: Li, Wendi
name: Wu, Jialin
name: Huang, Di
name: Jiang, Lingyan
name: Yang, Bin
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Enterohemorrhagic Escherichia coli (EHEC) O157:H7 (O157) is a major foodborne pathogen that causes severe illness in humans worldwide. The genome of O157 contains 177 genomic islands known as O islands (OIs), including Shiga toxin-converting phages (OI-45 and OI-93) and the locus for enterocyte effacement (LEE) pathogenicity island (OI-148). However, most genes in OIs are uncharacterized and code for unknown functions. In this study, we demonstrated, for the first time, that OI-9 encodes a novel transcriptional activator, Z0346 (named OvrB), which is required for bacterial adherence to host cells and LEE gene expression in O157. OvrB directly binds to the promoter region of LEE1 and activates the transcription of ler (encoding a master regulator of LEE genes), which in turn activates LEE1–5 genes to promote O157 adherence. Furthermore, mouse oral infection assays showed that OvrB promotes O157 colonization in the mouse intestine. Finally, OvrB is shown to be a widespread transcriptional activator of virulence genes in other enterohemorrhagic and enteropathogenic Escherichia coli serotypes. Our work significantly expands the understanding of bacterial virulence control and provides new evidence suggesting that horizontally transferred regulator genes mediate LEE gene expression.
Scalar-Fluid interacting dark energy: cosmological dynamics beyond the exponential potential
Creators: name: Dutta, Jibitesh
name: Khyllep, Wompherdeiki
name: Tamanini, Nicola
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We extend the dynamical systems analysis of Scalar-Fluid interacting dark energy models performed in C. G. Boehmer et al, Phys. Rev. D 91, 123002 (2015), by considering scalar field potentials beyond the exponential type. The properties and stability of critical points are examined using a combination of linear analysis, computational methods and advanced mathematical techniques, such as centre manifold theory. We show that the interesting results obtained with an exponential potential can generally be recovered also for more complicated scalar field potentials. In particular, employing power-law and hyperbolic potentials as examples, we find late time accelerated attractors, transitions from dark matter to dark energy domination with specific distinguishing features, and accelerated scaling solutions capable of solving the cosmic coincidence problem.
description: 20 pages, 9 figures, 3 tables; accepted by Phys. Rev. D
Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening
Creators: name: Benítez, Diego
name: Franco, Jaime
name: Sardi, Florencia
name: Leyva, Alejandro
name: Durán, Rosario
name: Choi, Gahee
name: Yang, Gyongseon
name: Kim, Taehee
name: Kim, Namyoul
name: Heo, Jinyeong
name: Kim, Kideok
name: Lee, Honggun
name: Choi, Inhee
name: Radu, Constantin
name: Shum, David
name: No, Joo Hwan
name: Comini, Marcelo A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular target for drug development against pathogens causing severe and fatal diseases in mammals. A drug discovery campaign aimed to identify and characterise new inhibitors of TryS with promising biological activity was conducted. A large compound library (n = 51,624), most of them bearing drug-like properties, was primarily screened against TryS from Trypanosoma brucei (TbTryS). With a true-hit rate of 0.056%, several of the TbTryS hits (IC50 from 1.2 to 36 µM) also targeted the homologue enzyme from Leishmania infantum and Trypanosoma cruzi (IC50 values from 2.6 to 40 µM). Calmidazolium chloride and Ebselen stand out for their multi-species anti-TryS activity at low µM concentrations (IC50 from 2.6 to 13.8 µM). The moieties carboxy piperidine amide and amide methyl thiazole phenyl were identified as novel TbTryS inhibitor scaffolds. Several of the TryS hits presented one-digit µM EC50 against T. cruzi and L. donovani amastigotes but proved cytotoxic against the human osteosarcoma and macrophage host cells (selectivity index ≤ 3). In contrast, seven hits showed a significantly higher selectivity against T. b. brucei (selectivity index from 11 to 182). Non-invasive redox assays confirmed that Ebselen, a multi-TryS inhibitor, induces an intracellular oxidative milieu in bloodstream T. b. brucei. Kinetic and mass spectrometry analysis revealed that Ebselen is a slow-binding inhibitor that modifies irreversible a highly conserved cysteine residue from the TryS’s synthetase domain. The most potent TbTryS inhibitor (a singleton containing an adamantine moiety) exerted a non-covalent, non-competitive (with any of the substrates) inhibition of the enzyme. These data feed the drug discovery pipeline for trypanosomatids with novel and valuable information on chemical entities with drug potential.
Role of α and β Transmembrane Domains in Integrin Clustering
Creators: name: Shamloo, Amir
name: Ashkan Golgoon
name: Zadeh, Ebrahim Ghafar
Publisher: name: figshare
Year: 2018
Subjects: subject: 30406 Proteins and Peptides
subject: FOS: Chemical sciences
subject: 10399 Numerical and Computational Mathematics not elsewhere classified
subject: FOS: Mathematics
subject: 10301 Numerical Analysis

description: Integrins are transmembrane proteins playing a crucial role in the mechanical signal transduction from the outside to the inside of a cell, and vice versa. Nevertheless, this signal transduction could not be implemented by a single protein. Rather, in order for integrins to be able to participate in signal transduction, they need to be activated and produce clusters first. As integrins consist of α- and β-subunits that are separate in the active state, studying both subunits separately is of a great importance, for, in the active state, the distance between α- and β-subunits is long enough that they do not influence one another significantly. Thus, this study aims to investigate the tendency of transmembrane domains of integrins to form homodimers. We used both Steered and MARTINI Coarse-grained molecular dynamics method to perform our simulations, mainly because of a better resolution and computational feasibility that each of these methods could provide to us. Using the Steered molecular dynamics method for α- and β-subunits, we found that the localized lipid packing prevented them from clustering. Nonetheless, the lipid packing phenomenon was found to be an artifact after investigating this process using a coarse grained (CG) model. Exploiting the coarse-grained molecular dynamics simulations, we found that α- and β-subunits tend to form a stable homo-dimer.
title: Una inscripción fenicia arcaica en el área de los templos de Lixus
title: Una inscripción fenicia arcaica en el área de los templos de Lixus
titleType: Subtitle
Creators: name: López Pardo, Fernando
name: Ruiz Cabrero, Luis Alberto
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Lixus
subject: Lixus

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Die Neubearbeitung der neunziger Jahre des unter dem Namen ‘Quartier de temples’ bekannten Gebäudekomplexes in Lixus stellten die hohe Datierung des Tempels H in Frage, was zu einem späten Zeitansatz des Gesamtkomplexes führte. Unser Beitrag behandelt zwei Amphorengraffiti der Zeit zwischen dem 8. und 1. Drittel des 7. Jhs. v. Chr. aus diesem Bezirk. Ursprünglich identifizierte man den Inschriftenträger mit anderer, späterer Keramik. Die Paläographie der Graffiti stimmt mit der frühen Datierung der Amphorenformen überein. Die neue Lesung der ersten Inschrift zeigt, dass es sich dabei um Gefäße handelt, die im Kontext des Heiligtums benutzt wurden. Zwei alternative Lesungen des ersten Graffito werden vorgeschlagen: 1. ... ]der Altar [für/des... ...wurde ge]geben Ger[... 2. -]hm Opfer/Opfernder[für/des ...hat ge]geben Ger[... Beide Graffiti gehörten zu einem chronologisch homogenen Material aus einer Sondage neben einer der Mauern des Gebäudes A des ‘Quartier des temples’. Es bestätigt, dass dieser Bezirk seit Anfang an bis in römische Zeit für kultische Zwecke bestimmt war. Außerdem behandeln wir die Frage, ob es eine unmittelbare Verbindung zwischen den archäologischen Materialien des 8. und Anfang des 7. Jhs. v. Chr., und dem Gebäude A bestanden. Diese Verbindungen konnten jedoch nicht bestätigt werden. Außerdem wird der Frage nach der Gottheit bzw. den Gottheiten nachgegangen, denen dieser Bezirk geweiht war, wofür in erster Linie Astarte und Baal Hammon in Frage kommen.
title: Zur spanischen Ausgabe von »Tarschisch und Hispanien«
title: Zur spanischen Ausgabe von »Tarschisch und Hispanien«
titleType: Subtitle
Creators: name: Koch, Michael
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
Circumferentially-Symmetric Finite Eigenstrains in Incompressible Isotropic Nonlinear Elastic Wedges
Creators: name: Ashkan Golgoon
name: Souhayl Sadik
name: Yavari, Arash
Publisher: name: figshare
Year: 2018
Subjects: subject: Mechanics
subject: 91308 Solid Mechanics
subject: FOS: Mechanical engineering
subject: 10207 Theoretical and Applied Mechanics
subject: FOS: Mathematics

description: Eigenstrains are created as a result of anelastic effects such as defects, temperature changes, bulk growth, etc., and strongly affect the overall response of solids. In this paper, we study the residual stress and deformation fields of an incompressible, isotropic, infinite wedge due to a circumferentially-symmetric distribution of finite eigenstrains. In particular, we establish explicit exact solutions for the residual stresses and deformation of a neo-Hookean wedge containing a symmetric inclusion with finite radial and circumferential eigenstrains. In addition, we numerically solve for the residual stress field of a neo-Hookean wedge induced by a symmetric Mooney-Rivlin inhomogeneity with finite eigenstrains.
title: Un vaso con decoración cordada en Galicia y el problema de los orígenes de la cerámica campaniforme en el Occidente ibérico
title: Un vaso con decoración cordada en Galicia y el problema de los orígenes de la cerámica campaniforme en el Occidente ibérico
titleType: Subtitle
Creators: name: Suárez Otero, José
name: Lestón Gómez, Manuel
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Das aus dem zerstörten Tumulus vom Monte dos Marxos (Rodeiro, Pontevedra) stammende Gefäß erweitert unsere Kenntnis zur Zeitstellung und zur Werkstatt der schnurverzierten Glockenbecher der Iberischen Halbinsel. Es diente vermutlich als eine Grabbeigabe, die in den Dolmen im Zuge seiner Wiederbenutzung gelangte, nicht ganz ungewöhnlich auch bei anderen Varianten der Glockenbecher und durchaus in die Zeit der Mitte des 3. Jts. v. Chr. passend. Die Oberfläche des gesamten Gefäßes ist durch doppelte Schnurlinien in gleichmäßigen Abständen verziert, es weist einen tiefen Umbruch, einen flachen Boden und einen leicht eingeschwungenen Hals auf, insgesamt eine für die schnurverzierte Keramik des spanischen Nordwestens wie auch seiner Ausstrahlung nach Süden typische Gestaltung. Sie präsentiert sich als eine eigene Gruppe, die gleichzeitig mitteleuropäische Verbindungen und Unterschiede zu den mediterranen Glockenbechern aufweist. Dieses Beispiel belegt die besondere Bedeutung dieser Glockenbechervariante im spanischen Nordwesten, während sie sonst nur spärlich auf der Halbinsel belegt wird, wo sie in Umgebungen wie des Hauses, der Gräber und sowohl gleichzeitig wie auch vermutlich von gleicher Bedeutung wie anderer Zeugnisse der Glockenbecher vorkommen.
New method to study ion-molecule reactions at low temperatures and application to the H$_2^+$ + H$_2$ $\rightarrow$ H$_3^+$ + H reaction
Creators: name: Allmendinger, Pitt
name: Deiglmayr, Johannes
name: Schullian, Otto
name: Höveler, Katharina
name: Agner, Josef A.
name: Schmutz, Hansjürg
name: Merkt, Frédéric
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Studies of ion-molecule reactions at low temperatures are difficult because stray electric fields in the reaction volume affect the kinetic energy of charged reaction partners. We describe a new experimental approach to study ion-molecule reactions at low temperatures and present, as example, a measurement of the ${\rm H}_2^+ + {\rm H}_2\rightarrow {\rm H}_3^+ + {\rm H}$ reaction with the ${\rm H}_2^+$ ion prepared in a single rovibrational state at collision energies in the range $E_{\rm col}/k_{\rm B} = 5$-60 K. To reach such low collision energies, we use a merged-beam approach and observe the reaction within the orbit of a Rydberg electron, which shields the ions from stray fields. The first beam is a supersonic beam of pure ground-state H$_2$ molecules and the second is a supersonic beam of H$_2$ molecules excited to Rydberg-Stark states of principal quantum number $n$ selected in the range 20-40. Initially, the two beams propagate along axes separated by an angle of 10$^\circ$. To merge the two beams, the Rydberg molecules in the latter beam are deflected using a surface-electrode Rydberg-Stark deflector. The collision energies of the merged beams are determined by measuring the velocity distributions of the two beams and they are adjusted by changing the temperature of the pulsed valve used to generate the ground-state ${\rm H}_2$ beam and by adapting the electric-potential functions to the electrodes of the deflector. The collision energy is varied down to below $E_{\rm col}/k_{\rm B}= 10$ K, i.e., below $E_{\rm col}\approx 1$ meV, with an energy resolution of 100 $μ$eV. We demonstrate that the Rydberg electron acts as a spectator and does not affect the cross sections, which are found to closely follow a classical-Langevin-capture model in the collision-energy range investigated. Because all neutral atoms and molecules can be excited to Rydberg states, this method of studying
description: 39 pages, 10 figures
FW/CADIS-$Ω$: An angle-informed hybrid method for deep-penetration radiation transport
Creators: name: Munk, Madicken
name: Slaybaugh, R. N.
name: Pandya, Tara M.
name: Johnson, Seth R.
name: Evans, T. M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: A new method for generating variance reduction parameters for strongly anisotropic, deep-penetration radiation shielding studies is presented. This method generates an alternate form of the adjoint scalar flux quantity, $ϕ^{\dagger}_Ω$, which is used by both CADIS and FW-CADIS to generate variance reduction parameters for local and global response functions, respectively. The new method, called CADIS-$Ω$, was implemented in the Denovo/ADVANTG software suite, and results are presented for a concrete labyrinth test problem. Results indicate that the flux generated by CADIS-$Ω$ incorporates localized angular anisotropies in the flux effectively. CADIS-$Ω$ outperformed CADIS in the test problem while obtaining accurate results. This initial work indicates that CADIS-$Ω$ may be highly useful for shielding problems with strong angular anisotropies. A future test plan to fully characterize the new method is proposed, which should reveal more about the types of realistic problems for which the CADIS-$Ω$ will be suited.
title: In memoriam Volker Pingel (1941-2005)
title: In memoriam Volker Pingel (1941-2005)
titleType: Subtitle
Creators: name: Schubart, Hermanfrid
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Volker Pingel (1941-2005)
subject: Volker Pingel (1941-2005)

description: Madrider Mitteilungen, Vol. 47 (2006)
description: In memoriam Volker Pingel (1941-2005).
Additional file 2 of Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients
Creators: name: Wang, Yanqun
name: Wang, Daxi
name: Zhang, Lu
name: Sun, Wanying
name: Zhang, Zhaoyong
name: Chen, Weijun
name: Zhu, Airu
name: Huang, Yongbo
name: Xiao, Fei
name: Yao, Jinxiu
name: Gan, Mian
name: Li, Fang
name: Luo, Ling
name: Huang, Xiaofang
name: Zhang, Yanjun
name: Wong, Sook-san
name: Cheng, Xinyi
name: Ji, Jingkai
name: Ou, Zhihua
name: Xiao, Minfeng
name: Li, Min
name: Li, Jiandong
name: Ren, Peidi
name: Deng, Ziqing
name: Zhong, Huanzi
name: Xu, Xun
name: Song, Tie
name: Mok, Chris Ka Pun
name: Peiris, Malik
name: Zhong, Nanshan
name: Zhao, Jingxian
name: Li, Yimin
name: Li, Junhua
name: Zhao, Jincun
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Fig. S1. Correlation of estimated alternative allele frequencies between metatranscriptomic and hybrid capture data. Fig. S2. Correlation of estimated minor alternative allele frequencies between biological replicates. Fig. S3. Correlation between sequencing depth and detected iSNVs. Fig. S4. Number of iSNV among three codon positions. Fig. S5. Haplotype frequency of proximal iSNVs within the gastrointestinal tract of patient P01.
On the Stress Field of a Nonlinear Elastic Solid Torus with a Toroidal Inclusion
Creators: name: Ashkan Golgoon
name: Yavari, Arash
Publisher: name: figshare
Year: 2018
Subjects: subject: Mechanics
subject: 91308 Solid Mechanics
subject: FOS: Mechanical engineering
subject: 10207 Theoretical and Applied Mechanics
subject: FOS: Mathematics

description: In this paper we analyze the stress field of a solid torus made of an incompressible isotropic solid with a toroidal inclusion that is concentric with the solid torus and has a uniform distribution of pure dilatational finite eigenstrains. We use a perturbation analysis and calculate the residual stresses to the first order in the \emph{thinness} ratio (the ratio of the radius of the generating circle and the overall radius of the solid torus). In particular, we show that the stress field inside the inclusion is not uniform. This is in contrast with the corresponding results for infinitely-long and finite circular cylindrical bars and spherical balls with cylindrical and spherical inclusions, respectively. We also show that for a solid torus of any size made of an incompressible linear elastic solid with an inclusion with uniform (infinitesimal) pure dilatational eigenstrains the stress inside the inclusion is not uniform.
Pulsar striped winds
Creators: name: Mochol, Iwona
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: According to magnetohydrodynamic (MHD) models, the rotational energy of a rapidly spinning neutron star is carried away by a relativistic wind and deposited at a large distance, in the nebula, downstream of the wind termination shock. The energy transport in the outflow is mediated by Poynting flux, but it is not clear how the energy stored in the fields is transferred into the energized population of emitting particles. The most plausible dissipation mechanisms are thought to be related to the "striped" structure of the wind, in particular, to the existence of a current sheet, prone to reconnection events. In this model the current sheet is a natural place for internal dissipation and acceleration of particles responsible for pulsed, high-energy emission. Moreover, reconnection is a promising scenario for explaining annihilation of fields at the shock and conversion of their energy into the kinetic energy of particles. The shock structure, however, is likely to differ in the low-density plasmas, in which non-MHD effects intervene. In this regime, the striped wind can dissipate its energy via an electromagnetic precursor of the shock.
description: invited review at the Workshop on Modelling Nebulae, June 14-17, 2016, Sant Cugat, Spain; submitted book chapter
4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies
Creators: name: Nada, Hossam
name: Elkamhawy, Ahmed
name: Abdellattif, Magda H.
name: Angeli, Andrea
name: Lee, Chang Hoon
name: Supuran, Claudiu T.
name: Lee, Kyeong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Hematology

description: Human carbonic anhydrase inhibitors (hCAIs) are a key therapeutic class with a multitude of novel applications such as anticonvulsants, topically acting antiglaucoma, and anticancer drugs. Herein, a new series of 4-anilinoquinazoline-based benzenesulfonamides were designed, synthesised, and biologically assessed as potential hCAIs. The target compounds are based on the well-tolerated kinase scaffold (4-anilinoquinazoline). Compounds 3a (89.4 nM), 4e (91.2 nM), and 4f (60.9 nM) exhibited 2.8, 2.7, and 4 folds higher potency against hCA I when compared to the standard (AAZ, V), respectively. A single digit nanomolar activity was elicited by compounds 3a (8.7 nM), 4a (2.4 nM), and 4e (4.6 nM) with 1.4, 5, and 2.6 folds of potency compared to AAZ (12.1 nM) against isoform hCA II, respectively. Structure-activity relationship (SAR) and molecular docking studies validated our design approach that revealed highly potent hCAIs.
title: Die mittelalterliche und neuzeitliche Keramik aus den Grabungen des Deutschen Archäologischen Instituts in Évora
title: Die mittelalterliche und neuzeitliche Keramik aus den Grabungen des Deutschen Archäologischen Instituts in Évora
titleType: Subtitle
Creators: name: Teichner, Felix
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis
Creators: name: Siwach, Kiran
name: Kumar, Amit
name: Panchal, Harish
name: Kumar, Rajiv
name: Bhardwaj, Jitender Kumar
name: Angeli, Andrea
name: Supuran, Claudiu T.
name: Sharma, Pawan K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Virology

description: In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides. All compounds were assayed for human carbonic anhydrase (hCA) isoforms I, II, IV, and IX inhibition. Isoforms hCA I and hCA IV were weakly inhibited by most of the synthesised compounds. Many four-substituted benzenesulphonamides displayed low nanomolar inhibition against isoform hCA II, unlike the three-substituted analogues. All target compounds exhibited good inhibition profile with KI values ranging from 16.4 to 66.0 nM against tumour-associated isoform hCA IX. Some selective and potent inhibitors of hCA IX were assayed for in vitro apoptotic induction in goat testicular cells. Compounds 10d and 10h showed interesting apoptotic induction potential. The present study may provide insights into a strategy for the design of novel anticancer agents based on hCA inhibitors endowed with apoptotic interference.
Additional file 4 of CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear cell renal cell carcinoma
Creators: name: Lv, Qi
name: Wang, Gangmin
name: Zhang, Yinan
name: Shen, Aijun
name: Tang, Junjun
name: Sun, Yi
name: Ma, Chunhui
name: Wang, Peijun
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 4: Supplemental Table 1. Clinicopathological variables of enrolled ccRCC patients. Supplemental Table 2. Association of circAGAP1 expression with clinicopathological variables in ccRCC.
title: A Study on Color Application and Perception in Urban Neighborhood Renewal Based on Simulation Comparison: Taking the Case of Kuangdaxuefu Street in Xuzhou, China
Creators: name: He, Fang
name: He, Yong
name: Sun, Liang
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/ Lodz University of Technology Press
Year: 2023
Subjects: Urban renewal, Urban color, Color perception, Color characteristic.

description: For the emotional needs of architectural color diversity in the renewal of urban micro-scale areas in China, this study intends to explore the trends in color perception which are influenced by changes in architectural color characteristics. In this study, the main color characteristics that influence the urban color renewal were determined through the preliminary basic investigation in China. The color psychological perception experiments were conducted by combining VR technology with questionnaire, so as to determine the correlation between architectural color characteristics and main color perceptions, as well as the correlation between different color perceptions.
title: Rudolf Schnyder y su articulo »La cerámica de paterna y la loza hispano-árabe del siglo XIV«
title: Rudolf Schnyder y su articulo »La cerámica de paterna y la loza hispano-árabe del siglo XIV«
titleType: Subtitle
Creators: name: Gómez Císcar, Reyes
name: Heidenreich, Anja
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Dieser Artikel entstand aus einer resümierenden Übersetzung eines forschungsgeschichtlich bedeutenden Beitrages zur Feinchronologie der spätmittelalterlichen Mudéjar-Keramik im Bereich der spanischen Levante. Durch den Autor, Prof. Dr. Rudolf Schnyder (Zürich) kürzlich kommentiert und aktualisiert, ermöglicht diese nun vorliegende spanische Version allen spanischen Kollegen unmittelbaren Zugang zu den ungewöhnlichen Methoden und Ergebnissen seiner Arbeit. Für die Beurteilung der charakteristischen 2-farbigen Waren auf weißem Grund (‘Verde-Manganeso- Keramik’) sowie ihrer nachfolgenden, kobaltblauen und lüsterverzierten Varianten, liegt hiermit ein Untersuchungsansatz vor, der gleichermaßen profunde kunstgeschichtliche Analysen der reichen Dekormotive und Stilnuancen wie auch Beobachtungen zur handwerklichen Produktionsweise der Töpfer liefert und diese in einem engen Chronologieschema zur Untergliederung dieser spätmittelalterlichen Prachtwaren umsetzt.
Nonlinear Elastic Inclusions in Anisotropic Solids
Creators: name: Ashkan Golgoon
name: Yavari, Arash
Publisher: name: figshare
Year: 2018
Subjects: subject: Mechanics
subject: 91308 Solid Mechanics
subject: FOS: Mechanical engineering
subject: 10207 Theoretical and Applied Mechanics
subject: FOS: Mathematics

description: In this paper we study the stress and deformation fields generated by nonlinear inclusions with finite eigenstrains in anisotropic solids. In particular, we consider finite eigenstrains in transversely isotropic spherical balls and orthotropic cylindrical bars made of both compressible and incompressible solids. We show that the stress field in a spherical inclusion with uniform pure dilatational eigenstrain in a spherical ball made of an incompressible transversely isotropic solid such that the material preferred direction is radial at any point is uniform and hydrostatic. Similarly, the stress in a cylindrical inclusion contained in an incompressible orthotropic cylindrical bar is uniform hydrostatic if the radial and circumferential eigenstrains are equal and the axial stretch is equal to a value determined by the axial eigenstrain. We also prove that for a compressible isotropic spherical ball and a cylindrical bar containing a spherical and a cylindrical inclusion, respectively, with uniform eigenstrains the stress in the inclusion is uniform (and hydrostatic for the spherical inclusion) if the radial and circumferential eigenstrains are equal. For compressible transversely isotropic and orthotropic solids, we show that the stress field in an inclusion with uniform eigenstrain is not uniform, in general. Nevertheless, in some special cases the material can be designed in order to maintain a uniform stress field in the inclusion. As particular examples to investigate such special cases, we consider compressible Mooney-Rivlin and Blatz-Ko reinforced models and find analytical expressions for the stress field in the inclusion.
Symmetries in superintegrable deformations of oscillator/Coulomb systems: "holomorphic factorization"
Creators: name: Hakobyan, Tigran
name: Nersessian, Armen
name: Shmavonyan, Hovhannes
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We propose a unified description for the constants of motion for superintegrable deformations of the oscillator and Coulomb systems on N-dimensional Euclidean space, sphere and hyperboloid. We also consider the duality between these generalized systems and present some example.
description: 12 pages
title: Die Ermita de Nuestra Señora de Peñalba bei Arnedillo (La Rioja)
title: Die Ermita de Nuestra Señora de Peñalba bei Arnedillo (La Rioja)
titleType: Subtitle
Creators: name: Schlimbach, Fedor
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Ermita de Nuestra Señora de Peñalba
subject: Arnedillo
subject: Ermita de Nuestra Señora de Peñalba
subject: Arnedillo
subject: Ermita de Nuestra Señora de Peñalba
subject: Arnedillo

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
Development of Praziquantel sulphonamide derivatives as antischistosomal drugs
Creators: name: Angeli, Andrea
name: Ferraroni, Marta
name: Carta, Fabrizio
name: Häberli, Cécile
name: Keiser, Jennifer
name: Costantino, Gabriele
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The almost empty armamentarium to treat schistosomiasis, a neglected parasitic disorder caused by trematode flatworms of the genus Schistosoma, except Praziquantel (PZQ), urged to find new alternatives to fight this infection. Carbonic Anhydrase from Schistosoma mansoni (SmCA) is a possible new target against this nematode. Here, we propose new PZQ derivatives bearing a primary sulphonamide group in order to obtain hybrid drugs. All compounds were evaluated for their inhibition profiles on both humans and Schistosoma CAs, X-ray crystal data of SmCA and hCA II in adduct with some inhibitors were obtained allowing the understanding of the main structural factors responsible of activity. The compounds showed in vitro inhibition of immature and adult S. mansoni, but further optimisation is required for improved activity.
title: Valdecebadar bei Olivenza (Badajoz). Neue Untersuchungen in der kreuzförmigen Kirche und ihrem Umfeld
title: Valdecebadar bei Olivenza (Badajoz). Neue Untersuchungen in der kreuzförmigen Kirche und ihrem Umfeld
titleType: Subtitle
Creators: name: Ulbert, Thilo
name: Eger, Christoph
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Valdecebadar
subject: Valdecebadar

description: Madrider Mitteilungen, Vol. 47 (2006)
description: Deutsche Zusammenfassung folgt.
Hidden population of Algols
Creators: name: Malkov, O. Yu.
name: Kovaleva, D. A.
name: Yungelson, L. R.
name: Avvakumova, E. A.
name: Chulkov, D. A.
name: Dluzhnevskaya, O. B.
name: Kniazev, A. Yu
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present results of Monte Carlo simulation aiming at the estimate of the frequency of semi-detached Algol-type binaries among the stars observed as single ones. When account is made for various detection biases (mostly due to inclination of orbits), the fraction of Algols among Galactic disk stars appears to be 0.1--0.2\%. However, this number should be regarded as a lower limit only, since there are still unaccounted selection effects and other types of photometrically unresolved binaries. Hidden binarity appears to be an important phenomenon that should be taken into account when considering stellar statistics and construction of fundamental relations between stellar parameters.
description: 9 pages, 8 figures
Gluino reach and mass extraction at the LHC in radiatively-driven natural SUSY
Creators: name: Baer, Howard
name: Barger, Vernon
name: Gainer, James S.
name: Huang, Peisi
name: Savoy, Michael
name: Sengupta, Dibyashree
name: Tata, Xerxes
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Radiatively-driven natural SUSY (RNS) models enjoy electroweak naturalness at the $10\%$ level while respecting LHC sparticle and Higgs mass constraints. Gluino and top squark masses can range up to several TeV (with other squarks even heavier) but a set of light Higgsinos are required with mass not too far above $m_h\sim 125$ GeV. Within the RNS framework, gluinos dominantly decay via ${\tilde g} \to t{\tilde t}_1^{*},\ \bar{t}{\tilde t}_1 \to t\bar{t}{\widetilde Z}_{1,2}$ or $t\bar{b}{\widetilde W}_1^-+c.c.$, where the decay products of the higgsino-like ${\widetilde W}_1$ and ${\widetilde Z}_2$ are very soft. Gluino pair production is, therefore, signalled by events with up to four hard $b$-jets and large ${\not\!\!{E_T}}$. We devise a set of cuts to isolate a relatively pure gluino sample at the (high luminosity) LHC and show that in the RNS model with very heavy squarks, the gluino signal will be accessible for $m_{\tilde g} < 2400 \ (2800)$ GeV for an integrated luminosity of 300 (3000) fb$^{-1}$. We also show that the measurement of the rate of gluino events in the clean sample mentioned above allows for a determination of $m_{\tilde g}$ with a statistical precision of $2.5-5\%$ (depending on the integrated luminosity and the gluino mass) over the range of gluino masses where a $5σ$ discovery is possible at the LHC.
description: 25 pages + frontpage. 13 figures consisting of 20 image files