cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stress-Stimulated Mitogen-Activated Protein Kinases Control the Stability and Activity of the Cdt1 DNA Replication Licensing Factor
Creators: name: Chandrasekaran, S.
name: Cook, J. G.
name: Hall, J. R.
name: Tan, T. X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: DNA replication is tightly coordinated both with cell cycle cues and with responses to extracellular signals to maintain genome stability. We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G1 phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G2 phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. Mutations that block normal cell cycle-regulated MAP kinase-mediated phosphorylation interfere with rapid Cdt1 reaccumulation at the end of S phase. Phosphomimetic mutations recapitulate the stabilizing effects of Cdt1 phosphorylation but also reduce the ability of Cdt1 to support origin licensing. Two other CRL4Cdt2 targets, the cyclin-dependent kinase (CDK) inhibitor p21 and the methyltransferase PR-Set7/Set8, are similarly stabilized by MAP kinase activity. These findings support a model in which MAP kinase activity in G2 promotes reaccumulation of a low-activity Cdt1 isoform after replication is complete.
Brief an Unbekannt
Creators: name: Metastasio, Pietro
Publisher: name: [s.n.]
Year: 1777

description: von Pietro Metastasio
description: Anrede "Illmo. [...] Sig. Sig.e [...]"
description: Italienisch
description: Den Brief erhielt Cäsar von Arx gemäss seinen beiliegenden eigenen Notizen im Dezember 1940 von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme hb
DAHe white dwarfs from the DESI survey
Creators: name: Manser, Christopher J.
name: Gänsicke, Boris T.
name: Inight, Keith
name: Robert, Akshay
name: Ahlen, S.
name: Prieto, C. Allende
name: Brooks, D.
name: Cooper, A. P.
name: de la Macorra, A.
name: Font-Ribera, A.
name: Honscheid, K.
name: Kisner, T.
name: Landriau, M.
name: Meisner, Aaron M.
name: Miquel, R.
name: Nie, Jundan
name: Poppett, C.
name: Tarlé, Gregory
name: Zhou, Zhimin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A new class of white dwarfs, dubbed DAHe, that present Zeeman-split Balmer lines in emission has recently emerged. However, the physical origin of these emission lines remains unclear. We present here a sample of 21 newly identified DAHe systems and determine magnetic field strengths and (for a subset) periods which span the ranges of ~ 6.5 -- 147 MG and ~ 0.4 -- 36 h respectively. All but four of these systems were identified from the Dark Energy Spectroscopic Instrument (DESI) survey sample of more than 47000 white dwarf candidates observed during its first year of observations. We present detailed analysis of the new DAHe WDJ161634.36+541011.51 with a spin period of 95.3 min, which exhibits an anti-correlation between broadband flux and Balmer line strength that is typically observed for this class of systems. All DAHe systems cluster closely on the Gaia Hertzsprung-Russell diagram where they represent ~ 1 per cent of white dwarfs within that region. This grouping further solidifies their unexplained emergence at relatively late cooling times and we discuss this in context of current formation theories. Nine of the new DAHe systems are identifiable from SDSS spectra of white dwarfs that had been previously classified as featureless DC-type systems. We suggest high S/N, unbiased observations of DCs as a possible route for discovering additional DAHe systems.
description: 19 pages, 10 Figures, accepted for publication in MNRAS
Computer and Information Literacy at the eighth grade: differences between boys and girls
Creators: name: Caponera, Elisa
name: Annunziata, Francesco
name: Palmerio, Laura
Publisher: name: Universita' degli Studi di Salerno
Year: 2022
Subjects: ICILS
Gender differences
Computer literacy

description: In recent decades, ICT has radically transformed our daily lives, work and social relationships, trying to understand how young people are prepared for this new challenge iscrucial.This study investigated the gender differences in International Computer and Information Literacy Study(ICILS) results. Italian students participating in ICILS 2018 (n=2810; mean age:13,3) were considered. The sample was representative of Italian students at the beginning of the eighth grade. Students answered the CIL (Computer and Information Literacy) international questionnaire including questions about students’ socio-economic and cultural background, future expectations about ICT usage for work and study, ICT skills to complete a range of different tasks, self-efficacy towards ICT.A structural equation model (SEM) was adopted to perform a path analysis to test a relationship between student characteristics and CIL performance.The results evidenced thatthe relationships between CIL, on one hand, and self-confidence andexpectations for the use of ICT for work and study, on the other hand, differ between boys and girls. Moreover, self-efficacy mediates the variables’ effects for the girls: a higher level of self-efficacy reinforces the relationship between ICT Learning and CIL.On the basis of the results, some possible implications for the Italian school system are discussed
I canovacci della Commedia dell'Arte: una prospettiva di catalogazione
Creators: name: CORPETTI, CECILIA
Publisher: name: Università degli studi di Genova
Year: 2023
Subjects: subject: Commedia dell'Art; canvases; improvisation; digital archive; users; usability; unpublished
subject: Commedia dell'Art
subject: canvases
subject: improvisation
subject: digital archive
subject: users
subject: usability
subject: unpublished

description: The Commedia dell'Arte made use of a so-called subject writing: the shows appeared staged in a "concentrated" way starting from synthesis writings, often final of previous setups. The dramaturgical archive of the history of the theater is therefore equipped with a rich corpus made up of "scenarios" or "diagnosis" and this immense heritage still escapes us today the possibility of counting on a platform that can guarantee consultation, comparison and a critical textual analysis. It is in the light of this aspect that the need to insert these arises materials within a study that presents them as they really are not (i.e. scriptures extended plays) thus preventing them from escaping a stricto sensu philological comparison. The object of this research is therefore the creation of an online platform in which to catalog i rare manuscripts from the heyday of the Commedia dell'Arte, on a range of subjects taken in examination from the works of Ludovico Zorzi and Annamaria Testaverde, taking into account the established dictates from the Central Institute of the Single Catalog and from the main digital archives present in the panorama of CD. The usability of the software, aimed at specialized and pertinent libraries but also at universities university students and individual scholars, is the basis of the project.
Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail
Creators: name: Heo, K.
name: Kim, H.
name: Choi, J.
name: Kim, K.
name: Xiong, Y.
name: An, W.
name: Jackson, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: HIV-1 Vpr-binding protein (VprBP) has been implicated in the regulation of both DNA replication and cell cycle progression, but its precise role remains unclear. Here we report that VprBP regulates the p53-induced transcription and apoptotic pathway. VprBP is recruited to p53-responsive promoters and suppresses p53 transactivation in the absence of stress stimuli. To maintain target promoters in an inactive state, VprBP stably binds to nucleosomes by recognizing unacetylated H3 tails. Promoter-localized deacetylation of H3 tails is a prerequisite for VprBP to tether and act as a bona fide inhibitor at p53 target genes. VprBP knockdown leads to activation of p53 target genes and causes an increase in DNA damage-induced apoptosis. Moreover, phosphorylation of VprBP at serine 895 impairs the ability of VprBP to bind H3 tails and to repress p53 transactivation. Our results thus reveal a new role for VprBP in regulation of the p53 signaling pathway, as well as molecular mechanisms of cancer development related to VprBP misregulation.
Limitations in timing precision due to single-pulse shape variability in millisecond pulsars
Creators: name: Shannon, R. M.
name: Osłowski, S.
name: Dai, S.
name: Bailes, M.
name: Hobbs, G.
name: Manchester, R. N.
name: van Straten, W.
name: Raithel, C. A.
name: Ravi, V.
name: Toomey, L.
name: Bhat, N. D. R.
name: Burke-Spolaor, S.
name: Coles, W. A.
name: Keith, M. J.
name: Kerr, M.
name: Levin, Y.
name: Sarkissian, J. M.
name: Wang, J. -B.
name: Wen, L.
name: Zhu, X. -J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: High-sensitivity radio-frequency observations of millisecond pulsars usually show stochastic, broadband, pulse-shape variations intrinsic to the pulsar emission process. These variations induce jitter noise in pulsar timing observations; understanding the properties of this noise is of particular importance for the effort to detect gravitational waves with pulsar timing arrays. We assess the short-term profile and timing stability of 22 millisecond pulsars that are part of the Parkes Pulsar Timing Array sample by examining intra-observation arrival time variability and single-pulse phenomenology. In 7 of the 22 pulsars, in the band centred at approximately 1400MHz, we find that the brightest observations are limited by intrinsic jitter. We find consistent results, either detections or upper limits, for jitter noise in other frequency bands. PSR J1909-3744 shows the lowest levels of jitter noise, which we estimate to contribute $\sim$10 ns root mean square error to the arrival times for hour-duration observations. Larger levels of jitter noise are found in pulsars with wider pulses and distributions of pulse intensities. The jitter noise in PSR J0437-4715 decorrelates over a bandwidth of $\sim$2 GHz. We show that the uncertainties associated with timing pulsar models can be improved by including physically motivated jitter uncertainties. Pulse-shape variations will limit the timing precision at future, more sensitive, telescopes; it is imperative to account for this noise when designing instrumentation and timing campaigns for these facilities.
description: 21 pages, 23 figures, accepted by MNRAS
A Complex Containing the CPSF73 Endonuclease and Other Polyadenylation Factors Associates with U7 snRNP and Is Recruited to Histone Pre-mRNA for 3'-End Processing
Creators: name: Marzluff, W. F.
name: Dadlez, M.
name: Debski, J.
name: Kaus-Drobek, M.
name: Sabath, I.
name: Yang, X.-C.
name: Dominski, Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Animal replication-dependent histone pre-mRNAs are processed at the 3′ end by endonucleolytic cleavage that is not followed by polyadenylation. The cleavage reaction is catalyzed by CPSF73 and depends on the U7 snRNP and its integral component, Lsm11. A critical role is also played by the 220-kDa protein FLASH, which interacts with Lsm11. Here we demonstrate that the N-terminal regions of these two proteins form a platform that tightly interacts with a unique combination of polyadenylation factors: symplekin, CstF64, and all CPSF subunits, including the endonuclease CPSF73. The interaction is inhibited by alterations in each component of the FLASH/Lsm11 complex, including point mutations in FLASH that are detrimental for processing. The same polyadenylation factors are associated with the endogenous U7 snRNP and are recruited in a U7-dependent manner to histone pre-mRNA. Collectively, our studies identify the molecular mechanism that recruits the CPSF73 endonuclease to histone pre-mRNAs, reveal an unexpected complexity of the U7 snRNP, and suggest that in animal cells polyadenylation factors assemble into two alternative complexes—one specifically crafted to generate polyadenylated mRNAs and the other to generate nonpolyadenylated histone mRNAs that end with the stem-loop.
Additional file 1 of Efficacy of a culturally tailored cognitive-behavioural intervention for Ethiopian children with haematological malignancies: study protocol for randomised controlled trial
Creators: name: Melesse, Tenaw Gualu
name: Chau, Janita Pak Chun
name: Li, William Ho Cheung
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1.
MODELING OF INNOVATIVE LIGHTER-THAN-AIR UAV FOR LOGISTICS, SURVEILLANCE AND RESCUE OPERATIONS
Creators: name: ROZHOK, ANASTASIIA
Publisher: name: Università degli studi di Genova
Year: 2023

description: An unmanned aerial vehicle (UAV) is an aircraft that can operate without the presence of pilots, either through remote control or automated systems. The first part of the dissertation provides an overview of the various types of UAVs and their design features. The second section delves into specific experiences using UAVs as part of an automated monitoring system to identify potential problems such as pipeline leaks or equipment damage by conducting airborne surveys.Lighter-than-air UAVs, such as airships, can be used for various applications, from aerial photography, including surveying terrain, monitoring an area for security purposes and gathering information about weather patterns to surveillance. The third part reveals the applications of UAVs for assisting in search and rescue operations in disaster situations and transporting natural gas. Using PowerSim software, a model of airship behaviour was created to analyze the sprint-and-drift concept and study methods of increasing the operational time of airships while having a lower environmental impact when compared to a constantly switched-on engine. The analysis provided a reliable percentage of finding the victim during patrolling operations, although it did not account for victim behaviour. The study has also shown that airships may serve as a viable alternative to pipeline transportation for natural gas. The technology has the potential to revolutionize natural gas transportation, optimizing efficiency and reducing environmental impact. Additionally, airships have a unique advantage in accessing remote and otherwise inaccessible areas, providing significant benefits in the energy sector. The employment of this technology was studied to be effective in specific scenarios, and it will be worth continuing to study it for a positive impact on society and the environment.
The IACOB project VIII. Searching for empirical signatures of binarity in fast-rotating O-type stars
Creators: name: Britavskiy, N.
name: Simón-Díaz, S.
name: Holgado, G.
name: Burssens, S.
name: Apellániz, J. Maíz
name: Eldridge, J. J.
name: Nazé, Y.
name: González, M. Pantaleoni
name: Herrero, A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The empirical distribution of projected rotational velocities (vsini) in massive O-type stars is characterized by a dominant slow velocity component and a tail of fast rotators. Binary interaction has been proposed to play a dominant role in the formation of this tail. We perform a complete and homogeneous search for empirical signatures of binarity in a sample of 54 fast-rotating stars with the aim of evaluating this hypothesis. This working sample has been extracted from a larger sample of 415 Galactic O-type stars which covers the full range of vsini values. We use new and archival multi-epoch spectra in order to detect spectroscopic binary systems. We complement this information with Gaia proper motions and TESS photometric data to aid in the identification of runaway stars and eclipsing binaries, respectively. The identified fraction of single-lined spectroscopic binary (SB1) systems and apparently single stars among the fast-rotating sample is $\sim$18% and $\sim$70%, respectively. When comparing these percentages with those corresponding to the slow-rotating sample we find that our sample of fast rotators is characterized by a slightly larger percentage of SB1 systems ($\sim$18% vs. $\sim$13%) and a considerably smaller fraction of clearly detected SB2 systems (8% vs. 33%). Overall, there seems to be a clear deficit of spectroscopic binaries (SB1+SB2) among fast-rotating O-type stars ($\sim$26% vs. $\sim$46%). On the contrary, the fraction of runaway stars is significantly higher in the fast-rotating domain ($\sim$33-50%) than among those stars with vsini < 200 km/s. Lastly, almost 65% of the apparently single fast-rotating stars are runaways. Our empirical results seem to be in good agreement with the idea that the tail of fast-rotating O-type stars (with vsini > 200 km/s) is mostly populated by post-interaction binary products.
description: 33 pages, 16 figures, accepted for publication in "Astronomy and Astrophysics"
Giovani musulmani italiani. Appartenenza religiosa, socializzazione e agenzie socializzative
Creators: name: Crescenti, Martini
Publisher: name: Universita' degli Studi di Salerno
Year: 2021
Subjects: Religious affiliation
Islamic socialisation
Islamic youth

description: In recent decades, the Islamic community has seen the emergence of new generations of Muslims who find themselves having to negotiate between their Islamic affiliation, their family ethnic culture and their Italian culture in order to be and feel fully included. This causes them doubts and second thoughts about their belonging to Islam, and they expe-rience challenges and conflicts in their relationships with their families, peers and ac-quaintances. On these considerations, we present a qualitative research, conducted in 2020, which analyses the relational and social dynamics through which young people con-struct their belonging to Islam. The analysis is based on ten interviews with young Mus-lims with roles of responsibility in some local and national Islamic associations, which can offer an overall and differentiated view of the phenomenon. The results analyse the young people's socialisation pathway in three agencies considered central in their lives: family, youth association, and social media. On the one hand, the family constitutes a sig-nificant space for building belonging to the religion, since it is the first agent that forms according to Islamic values; on the other hand, associations and social media represent spaces of autonomous choice in which the young person builds his relationship with Islam
Postkarte an [Gertrud] von Arx
Creators: name: Geigy-Hagenbach, Karl
Publisher: name: [s.n.]
Year: 1947

description: von K[arl] Geigy Hagenbach
description: Deutsch
description: Verzeichnung=Description=Inventaire Juni 2022 HAN-Katalogisierungsregeln HBr
Rapid assessment of biodiversity using 'biological diversity technicians'
Creators: name: Cranston, Peter
name: Hillman, Terry
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Faced with the decline in traditional taxonomy an enhanced role for ‘biological diversity technicians’ has been advocated to meet increasing demands for taxanomic services from biodiversity studies. We have identified several assumptions made in advocating the use of such a labour force in rapid assessment of biodiversity. When tested in selected aquatic ecosystems, effectiveness of sampling and accuracy of sorting to certain taxonomic levels was confirmed, but several problems with species segregation were identified. Faulty estimation of the number and identity of species has serious consequences for biodiversity studies.The concept of ‘indicator groups’ that allow inference of total community diversity is assessed and found to be poorly substantiated. The term should be replaced by ‘selected groups’, pending further study. Changes in the role of traditional taxonomists in diversity studies are suggested, particularly incorporation of taxonomists from the outset of biodiversity studies.
Three-Dimensional Nanoporous Graphene Substrate for Surface-Enhanced Raman Scattering
Creators: name: Tu, Zhiqiang
name: Wu, Shangfei
name: Yang, Fan
name: Li, Yongfeng
name: Zhang, Liqiang
name: Liu, Hongwen
name: Ding, Hong
name: Richard, Pierre
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We synthesized three-dimensional nanoporous graphene films by a chemical vapor deposition method with nanoporous copper as a catalytic substrate. The resulting nanoporous graphene has the same average pore size as the underlying copper substrate. Our surface-enhanced Raman scattering (SERS) investigation indicates that the nanoporosity of graphene significantly improves the SERS efficiency of graphene as a substrate as compared to planar graphene substrates.
description: 5 pages, 4 figures
title: Assessment of chimeric antigen receptors containing non-canonical signaling domains: Comparative evaluation in different immune cells
Creators: name: Albrecht, Leoni
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Background and objectives: The diagnosis of metastatic malignancy is in most cases associated with poor prognosis, because of limited treatment options available. Regarding hematological malignancies, CAR-cell therapies have added a potent option to the treatment offering, while such breakthroughs are still lacking in solid tumors. Characteristics as the physical and chemical barriers surrounding solid tumors and the hostile tumor micro-environment remain significant obstacles. Methods: To overcome these, two approaches were combined in this study: Six new developed CARs, employing less explored signaling domains (CD32A, Dap10 and NKG2D-short), targeting the melanoma antigen CSPG4 and the breast cancer antigen ErbB2, were tested in different, promising immune cell types, including PBMCs, CD8+ T cells, NK cells, and the NK cell line NK3.3. Furthermore, an established anti-CSPG4-CD28/CD3 CAR, was tested in these cell types too, and in addition in primary monocytes and the monocytic cell line THP-1. The method used for transfection was mRNA electroporation, which first had to be established for the primary monocytes and THP-1 cells, since they were not yet used for this purpose. Post-electroporation, cell yield was determined by cell counting, and expression of the different CARs was quantified via flow-cytometry. The functionality of the CAR-cells was tested by determining cytokine release after target-cell stimulation. Results and observations: As primary monocytes and the monocytic cell line THP-1 had not been used for this purpose before, an electroporation protocol was first established. In most cases, mRNA electroporation resulted in CAR expression on the different immune cell types with an overall good cell yield. The anti-CSPG4-CD28/CD3 CAR was also detected on cells where it would not have been expected, including primary NK cells, NK3.3 cells, primary monocytes and THP-1 cells. Only CARs with the NKG2D-short signaling domain were not detectable on any cell type. Antigen-specific cytokine release was only detectable in anti-CSPG4-CD28/CD3 CAR-expressing cells, but remarkably in almost all cell types examined. Conclusions and discussion: These results suggest that it is worthwhile to further investigate the anti-CSPG4-CD28/CD3 CAR in NK cells and primary monocytes, as these cells have unique properties in fighting solid tumors. In addition, the expression of CARs with new signaling domains is a promising result and warrants continued functional testing and further development and refinement of the CARs. In order to create a diverse repertoire of CAR formats/ immune cell combinations and thus expand the therapeutic arsenal against cancer, this approach should be further explored.
ARID1a-DNA Interactions Are Required for Promoter Occupancy by SWI/SNF
Creators: name: Schisler, J. C.
name: Magnuson, T.
name: Chandler, R. L.
name: Brennan, J.
name: Patterson, C.
name: Serber, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Every known SWI/SNF chromatin-remodeling complex incorporates an ARID DNA binding domain-containing subunit. Despite being a ubiquitous component of the complex, physiological roles for this domain remain undefined. Here, we show that disruption of ARID1a-DNA binding in mice results in embryonic lethality, with mutant embryos manifesting prominent defects in the heart and extraembryonic vasculature. The DNA binding-defective mutant ARID1a subunit is stably expressed and capable of assembling into a SWI/SNF complex with core catalytic properties, but nucleosome substrate binding and promoter occupancy by ARID1a-containing SWI/SNF complexes (BAF-A) are impaired. Depletion of ARID domain-dependent, BAF-A associations at THROMBOSPONDIN 1 (THBS1) led to the concomitant upregulation of this SWI/SNF target gene. Using a THBS1 promoter-reporter gene, we further show that BAF-A directly regulates THBS1 promoter activity in an ARID domain-dependent manner. Our data not only demonstrate that ARID1a-DNA interactions are physiologically relevant in higher eukaryotes but also indicate that these interactions facilitate SWI/SNF binding to target sites in vivo. These findings support the model wherein cooperative interactions among intrinsic subunit-chromatin interaction domains and sequence-specific transcription factors drive SWI/SNF recruitment.
Comparing charge transfer tuning effects by chemical substitution and uniaxial pressure in the organic charge transfer complex tetramethoxypyrene-tetracyanoquinodimethane
Creators: name: Rudloff, Milan
name: Ackermann, Kai
name: Huth, Michael
name: Jeschke, Harald O.
name: Tomic, Milan
name: Valenti, Roser
name: Wolfram, Benedikt
name: Bröring, Martin
name: Bolte, Michael
name: Chercka, Dennis
name: Baumgarten, Martin
name: Müllen, Klaus
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In the search for novel organic charge transfer salts with variable charge transfer degree we study the effects of two modifications to the recently synthesized donor-acceptor Tetramethoxypyrene (TMP)-Tetracyanoquinodimethane (TCNQ). One is of chemical nature by substituting the acceptor TCNQ molecules by F4TCNQ molecules. The second consists in simulating the application of uniaxial pressure along the stacking axis of the system. In order to test the chemical substitution, we have grown single crystals of TMP-F4TCNQ and analyzed its electronic structure via electronic transport measurements, ab initio density functional theory (DFT) calculations and UV/VIS/IR absorption spectroscopy. This system shows an almost ideal geometrical overlap of nearly planar molecules alternately stacked (mixed stack) and this arrangement is echoed by a semiconductor-like transport behavior with an increased conductivity along the stacking direction. This is in contrast to TMP-TCNQ which shows a less pronounced anisotropy and a smaller conductivity response. Our bandstructure calculations confirm the one-dimensional behavior of TMP-F4TCNQ with pro- nounced dispersion only along the stacking axis. Infrared measurements illustrating the CN vibration frequency shift in F4TCNQ suggest however no improvement on the degree of charge transfer in TMP-F4TCNQ with respect to TMP-TCNQ. In both complexes about 0.1 is transferred from TMP to the acceptor. Concerning the pressure effect, our DFT calculations on designed TMP-TCNQ and TMP-F4TCNQ structures under different pressure conditions show that application of uniaxial pressure along the stacking axis of TMP-TCNQ may be the route to follow in order to obtain a much more pronounced charge transfer.
Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice
Creators: name: Purushotham, A.
name: Kemper, J. K.
name: Xu, Q.
name: Foley, J. F.
name: Kim, D.-H.
name: Yan, X.
name: Lu, J.
name: Li, X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: SIRT1, a highly conserved NAD+-dependent protein deacetylase, is a key metabolic sensor that directly links nutrient signals to animal metabolic homeostasis. Although SIRT1 has been implicated in a number of hepatic metabolic processes, the mechanisms by which hepatic SIRT1 modulates bile acid metabolism are still not well understood. Here we report that deletion of hepatic SIRT1 reduces the expression of farnesoid X receptor (FXR), a nuclear receptor that regulates bile acid homeostasis. We provide evidence that SIRT1 regulates the expression of FXR through hepatocyte nuclear factor 1α (HNF1α). SIRT1 deficiency in hepatocytes leads to decreased binding of HNF1α to the FXR promoter. Furthermore, we show that hepatocyte-specific deletion of SIRT1 leads to derangements in bile acid metabolism, predisposing the mice to development of cholesterol gallstones on a lithogenic diet. Taken together, our findings indicate that SIRT1 plays a vital role in the regulation of hepatic bile acid homeostasis through the HNF1α/FXR signaling pathway.
Рейтинговая оценка зерноуборочных комбайнов по результатам хозяйственных испытаний в Амурской области
Creators: name: Лазарев Вадим Иванович
name: Лонцева Ирина Александровна
name: Чурилова Клавдия Семеновна
name: Овчинникова Ольга Фёдоровна
name: Никульчев Константин Анатольевич
Publisher: name: Дальневосточный аграрный вестник
Year: 2011
Subjects: ПЛОЩАДЬ ПАШНИ
ПЕРЕУВЛАЖНЕНИЕ ПОЧВЫ
ЗЕРНОУБОРОЧНЫЕ КОМБАЙНЫ
УРОЖАЙНОСТЬ
СЕРВИСНОЕ ОБСЛУЖИВАНИЕ
ПОЛЕВЫЕ ИСПЫТАНИЯ
РЕЙТИНГОВЫЕ ПОКАЗАТЕЛИ

description: В статье отражены результаты демонстрации работы зерноуборочных комбайнов и сравнительная экономическая оценка во время проведения семинара по уборке сои в Амурской области
Additional file 1 of Virulence genes distributed among Staphylococcus aureus causing wound infections and their correlation to antibiotic resistance
Creators: name: Rasmi, Asia Helmi
name: Ahmed, Eman Farouk
name: Darwish, Abdou Mohammed Abdullah
name: Gad, Gamal Fadl Mahmoud
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Figure S1. Detection of amplification product of hla gene by PCR; lane 1: negative control, lane 2: positive control and lanes 3 to 10: positive PCR products (209bp). Figure S2. Detection of amplification product of sea gene by PCR; lane 1: positive control, lane 2: negative control and lanes 3 to 11: positive PCR products (120bp). Figure S3. Detection of amplification product of icaA gene by PCR; lane 1: positive control, lane 2: negative control and lanes 3 to 10: positive PCR products (770bp). Figure S4. Detection of amplification product of fnbA gene by PCR; lanes 1 to 7: positive PCR products (1279bp), lane 8: positive control and lane 9: negative control
IB Kinase  Phosphorylation of TRAF4 Downregulates Innate Immune Signaling
Creators: name: Abbott, D. W.
name: Cantley, L. C.
name: Cobb, B. A.
name: Homer, C. R.
name: Marinis, J. M.
name: McDonald, C.
name: Hutti, J. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Despite their homology, IκB kinase α (IKKα) and IKKβ have divergent roles in NF-κB signaling. IKKβ strongly activates NF-κB while IKKα can downregulate NF-κB under certain circumstances. Given this, identifying independent substrates for these kinases could help delineate their divergent roles. Peptide substrate array technology followed by bioinformatic screening identified TRAF4 as a substrate for IKKα. Like IKKα, TRAF4 is atypical within its family because it is the only TRAF family member to negatively regulate innate immune signaling. IKKα's phosphorylation of serine-426 on TRAF4 was required for this negative regulation. Binding to the Crohn's disease susceptibility protein, NOD2, is required for TRAF4 phosphorylation and subsequent inhibition of NOD2 signaling. Structurally, serine-426 resides within an exaggerated β-bulge in TRAF4 that is not present in the other TRAF proteins, and phosphorylation of this site provides a structural basis for the atypical function of TRAF4 and its atypical role in NOD2 signaling.
The low density, hot Jupiter TOI-640 b is on a polar orbit
Creators: name: Knudstrup, Emil
name: Albrecht, Simon H.
name: Gandolfi, Davide
name: Marcussen, Marcus L.
name: Goffo, Elisa
name: Serrano, Luisa M.
name: Dai, Fei
name: Redfield, Seth
name: Hirano, Teruyuki
name: Csizmadia, Szilárd
name: Cochran, William D.
name: Deeg, Hans J.
name: Fridlund, Malcolm
name: Lam, Kristine W. F.
name: Livingston, John H.
name: Luque, Rafael
name: Narita, Norio
name: Palle, Enric
name: Persson, Carina M.
name: Van Eylen, Vincent
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: TOI-640 b is a hot, puffy Jupiter with a mass of $0.57 \pm 0.02$ M$_{\rm J}$ and radius of $1.72 \pm 0.05$ R$_{\rm J}$, orbiting a slightly evolved F-type star with a separation of $6.33^{+0.07}_{-0.06}$ R$_\star$. Through spectroscopic in-transit observations made with the HARPS spectrograph, we measured the Rossiter-McLaughlin effect, analysing both in-transit radial velocities and the distortion of the stellar spectral lines. From these observations, we find the host star to have a projected obliquity of $λ=184\pm3^\circ$. From the TESS light curve, we measured the stellar rotation period, allowing us to determine the stellar inclination, $i_\star=23^{+3\circ}_{-2}$, meaning we are viewing the star pole-on. Combining this with the orbital inclination allowed us to calculate the host star obliquity, $ψ=104\pm2^\circ$. TOI-640 b joins a group of planets orbiting over stellar poles within the range $80^\circ-125^\circ$. The origin of this orbital configuration is not well understood.
description: 15 pages, 12 figures, accepted for publication in A&A, in press
Non-commutativity from exact renormalization group dualities
Creators: name: Gangopadhyay, Sunandan
name: Scholtz, Frederik G
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Here we demonstrate, firstly, the construction of dualities using the exact renormalization group approach and, secondly, that spatial non-commutativity can emerge as such a duality. This is done in a simple quantum mechanical setting that establishes an exact duality between the commutative and non-commutative quantum Hall systems with harmonic interactions. It is also demonstrated that this link can be understood as a blocking (coarse graining) transformation in time that relates commutative and non-commutative degrees of freedom.
description: 6 pages Latex
Additional file 1 of Young people’s health and well-being during the school-to-work transition: a prospective cohort study comparing post-secondary pathways
Creators: name: Reuter, Marvin
name: Herke, Max
name: Richter, Matthias
name: Diehl, Katharina
name: Hoffmann, Stephanie
name: Pischke, Claudia R.
name: Dragano, Nico
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1: e-Table 1. Assessment for eligibility for study sample. e-Table 2. Criteria used to define nine mutually exclusive states during STWT. e-Table 3. Example for dividing the data set into multiple samples (S1-S6) for two participants. e-Figure 1. Proportion of states in each year after school-leave stratified by state entered in the first year out of school. e-Figure 2. Trajectories of self-rated health and subjective well-being after school-leave by gender. Data set: NEPS SC4, SUF 12.0.0. Regression coefficients and 95% confidence intervals of linear fixed-effect analysis with cluster-robust standard errors. Time-varying controls: Region of education or work, and household composition. Red horizontal line (0) represents average health and well-being during school.
“The bad girls of breast cancer”. Breast cancer and the U.S. grassroots group Breast Cancer Action, 1990-2010
Creators: name: DE MICHELE, GRAZIA
Publisher: name: Università degli studi di Genova
Year: 2023

description: This thesis focuses on the history of breast cancer in the United States at the turn of the twentieth-first century as seen through the eyes of the grassroots organization Breast Cancer Action (BCA). Since the middle 1990s, the alliance between corporations – from pharmaceutical giants to cosmetic companies - and non-profit entities turned breast cancer into a cause célèbre in whose name millions of dollars have been raised mostly through product sales and sports events. However, only a few years earlier, several grassroots patient-led organizations had started to leverage women’s lived experience of breast cancer with the aim of exposing the alleged lack of progress in the understanding and handling of the disease as well as its unprecedented rise in incidence, defined of epidemic proportions. BCA, founded in 1990 in San Francisco, was among the most prominent of these groups. In addition, as a result of the adoption of a pioneering policy of not accepting donations from corporations contributing to or profiting from cancer, the organization established itself as the watchdog of the breast cancer movement and its activists became known as the “bad girls of breast cancer”. The thesis is divided into five chapters, each covering one of the key aspects of breast cancer addressed by BCA since inception until 2010, when Barbara Brenner, its first full time Executive Director, retired. The first chapter discusses research politics; the second analyses BCA’s take on the two conflicting notions of prevention characterizing the history of cancer in the United States; the third covers issues related to treatment; the fourth focuses on the discovery in the 1990s of two genes – known as BRCA1 and BRCA2 - that, if mutated, can increase the risk of developing breast cancer and its consequences; the last chapter covers the transformation of breast cancer in a marketing tool allowing corporations – helped by breast cancer organizations – to increase their profits without having to innovate, by simply positioning themselves as supporters of the cause of breast cancer. During its first fifteen years of life, BCA vigorously opposed the idea that breast cancer could be the exclusive appanage of a biomedicine too focused on waging war to aberrant cells through molecular biology and genetics to look more broadly at the surrounding environment both inside and outside women’s bodies. In the view of the organization, breast cancer was a social justice matter requiring systemic change, a means to a much broader end concerning not only those living with the disease and their loved ones, but society as whole.
Insulin-Like Growth Factor (IGF) Binding Protein 2 Functions Coordinately with Receptor Protein Tyrosine Phosphatase  and the IGF-I Receptor To Regulate IGF-I-Stimulated Signaling
Creators: name: Shen, X.
name: Clemmons, D. R.
name: Xi, G.
name: Rosen, C. J.
name: Wai, C.
name: Maile, L. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Insulin-like growth factor I (IGF-I) is a mitogen for vascular smooth muscle cells (VSMC) and has been implicated in the development and progression of atherosclerosis. IGF binding proteins (IGFBPs) modify IGF-I actions independently of IGF binding, but a receptor-based mechanism by which they function has not been elucidated. We investigated the role of IGFBP-2 and receptor protein tyrosine phosphatase β (RPTPβ) in regulating IGF-I signaling and cellular proliferation. IGFBP-2 bound RPTPβ, which led to its dimerization and inactivation. This enhanced PTEN tyrosine phosphorylation and inhibited PTEN activity. Utilization of substrate trapping and phosphatase-dead mutants showed that RPTPβ bound specifically to PTEN and dephosphorylated it. IGFBP-2 knockdown led to decreased PTEN tyrosine phosphorylation and decreased AKT Ser473 activation. IGFBP-2 enhanced IGF-I-stimulated VSMC migration and proliferation. Analysis of aortas obtained from IGFBP-2−/− mice showed that RPTPβ was activated, and this was associated with inhibition of IGF-I stimulated AKT Ser473 phosphorylation and VSMC proliferation. These changes were rescued following administration of IGFBP-2. These findings present a novel mechanism for coordinate regulation of IGFBP-2 and IGF-I signaling functions that lead to stimulation of VSMC proliferation. The results have important implications for understanding how IGFBPs modulate the cellular response to IGF-I.
Rotifer from Australian inland waters VIII. Trichocercidae (Monogononta)
Creators: name: Shiel, R. J
name: Koste, W
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Diagnostic keys are given to the genera and species of the Australian representatives of Rotifera: Monogononta in the family Trichocercidae (Ascomorphella (1sp.), Elosa (1sp.) and Trichocerca (43 sp.)). All species known from Australian waters are described and figured. Distribution data and ecological information are also given.
Intelligence for automated manoeuvres; docking of a feeder vessel
Creators: name: De Kruif, Bas J.
Publisher: name: Zenodo
Year: 2022

description: MARIN R&D seminar 2022, took place on Wednesday 02 November 2022, in Wageningen. During this day MARIN’s new research programs on Zero Emission Shipping, Safe Operations & Human Factors, Autonomy & Decision Support and Blue Growth were presented. Within these programs, MARIN works on its mission to make ships cleaner, smarter and safer, and to contribute to a sustainable use of the sea. MOSES project was presented by Mr. Bas J. de Kruif, who delivered a presentation on “Intelligence for automated manoeuvres; docking of a feeder vessel”.
Conditional entropy of ordinal patterns
Creators: name: Unakafov, Anton M.
name: Keller, Karsten
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper we investigate a quantity called conditional entropy of ordinal patterns, akin to the permutation entropy. The conditional entropy of ordinal patterns describes the average diversity of the ordinal patterns succeeding a given ordinal pattern. We observe that this quantity provides a good estimation of the Kolmogorov-Sinai entropy in many cases. In particular, the conditional entropy of ordinal patterns of a finite order coincides with the Kolmogorov-Sinai entropy for periodic dynamics and for Markov shifts over a binary alphabet. Finally, the conditional entropy of ordinal patterns is computationally simple and thus can be well applied to real-world data.
Dashing through the cluster: An X-ray to radio view of UGC 10420 undergoing ram-pressure stripping
Creators: name: Mahajan, Smriti
name: Singh, Kulinder Pal
name: Tiwari, Juhi
name: Raychaudhury, Somak
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: We present multi-wavelength data and analysis, including new FUV AstroSat/UVIT observations of the spiral galaxy UGC 10420 (z=0.032), a member of the cluster Abell 2199. UGC 10420 is present on the edge of the X-ray emitting region of the cluster at a distance of ~ 680 kpc from the centre. The FUV data shows intense knots of star formation on the leading edge of the galaxy, accompanied by a tail of the same on the diametrically opposite side. Our analysis shows that the images of the galaxy disk in the optical and mid-infrared are much smaller in size than that in the FUV. While the broadband optical colours of UGC 10420 are typical of a post-starburst galaxy, the SFR derived from a UV-to-IR spectral energy distribution is at least a factor of nine higher than that expected for a star-forming field galaxy of similar mass at its redshift. A careful removal of the contribution of the diffuse intracluster gas shows that the significant diffuse X-ray emission associated with the inter-stellar medium of UGC 10420 has a temperature, T_X = 0.24^{+0.09}_{-0.06} keV (0.4-2.0 keV) and luminosity, L_X = 1.8+/-0.9 x 10^{40} erg/s, which are typical of the X-ray emission from late-type spiral galaxies. Our analysis favours a scenario where the interaction of a galaxy with the hot intra-cluster medium of the cluster, perturbs the gas in the galaxy causing starburst in the leading edge of the disk. On the other hand, the turbulence thus developed may also push some of the gas out of the disk. Interactions between the gas ejected from the galaxy and the intracluster medium can then locally trigger star formation in the wake of the galaxy experiencing ram-pressure stripping. Our data however does not rule out the possibility of a flyby encounter with a neighbouring galaxy, although no relevant candidates are observed in the vicinity of UGC 10420. (abridged)
description: Accepted for publication in the Publication of the Astronomical Society of Australia (PASA). 16 pages, 11 figures