cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hymenogadus Gilbert & Hubbs 1920
Creators: name: Schwarzhans, Werner
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gadiformes
Macrouridae
Hymenogadus

description: Hymenogadus Gilbert & Hubbs, 1920
 Hymenogadus Gilbert & Hubbs, 1920: 521, as subgenus of Hymenocephalus Giglioli, 1884, type species by original designation Hymenocephalus gracilis Gilbert & Hubbs, 1920.
 Hymenogadus: Okamura, 1970: 58.
 Hymenocephalus: Marshall & Iwamoto, 1973: 602; Sazonov & Iwamoto, 1992: 55; Iwamoto & Merrett, 1997: 518.
 Diagnosis. Modified from Okamura (1970). First spine of dorsal fin serrated. Ventral striae consisting of fine parallel lines of dark, alternating with silvery pigment associated with a light-producing function on abdominal wall, parts of chest, and shoulder girdle, not joint at median line behind pelvic fin bases. Head cavernous, with moderately thin skin cover. Median and lateral processes of snout sharply pointed, not plate-like. Gill rakers 10–19. Additional diagnostic features from axial skeleton and head morphology are: 11–12 precaudal vertebrae (based on radiographs). Widening of sensory canal systems on head; development of incipient infranasal, infraorbital and preopercular supporters; Hymenocephalus -like snout with broad, blunt, soft tip. Additional diagnostic features from otolith morphology are: Moderately elongate shape of otoliths (OL:OH = 1.25–1.55); elevated, but short predorsal lobe; ventral sulcus margin at collum indented; pseudocolliculum indistinct, short.
 Comparison. Hymenogadus resembles Spicomacrurus in a number of aspects, such as body shape, extent of ventral striae not joined behind the pelvic fin bases, otolith with an indented ventral sulcus margin at the collum, and short, indistinct pseudocolliculum. Certain other characters remind of the status seen in Hymenocephalus, such as the widening of the sensory canal system on the head, albeit covered by a thicker more robust skin than in Hymenocephalus, the lack of the spatulate nasal bones, the incipient developments of infranasal, infraorbital and preopercular supporters and the expanded, though short predorsal lobe in the otoliths.
 Species. Two species, one nearly cosmopolitan (H. gracilis), except for Hawaii, where it is replaced by the second, probably endemic species (H. tenuis).
description: Published as part of Schwarzhans, Werner, 2014, Head and otolith morphology of the genera Hymenocephalus, Hymenogadus and Spicomacrurus (Macrouridae), with the description of three new species, pp. 1-73 in Zootaxa 3888 (1) on pages 23-24, DOI: 10.11646/zootaxa.3888.1.1, http://zenodo.org/record/10086415
The effect of FAD-associated mutations in amyloid-beta precursor protein and presenilin-1 genes on Alzheimer’s disease pathogenesis.
Creators: name: Zhang, Shuting
Publisher: name: University of British Columbia
Year: 2014

description: Pathogenic mutations in amyloid-β precursor protein (APP) and presenilins (PS) genes cause familial Alzheimer’s disease (FAD). FAD is an uncommon form of Alzheimer’s disease (AD) with early onset (before age 65) and a rapid progression but its neuropathology is indistinguishable from the sporadic AD. Amyloid plaque is the unique hallmark of AD, which consists primarily of 40- and 42-residue amyloid β protein (Aβ40 and Aβ42) with the more hydrophobic Aβ42 as its major component. Aβ is derived from APP through sequential cleavages by β-secretase and γ-secretase. According to the “Amyloid hypothesis”, Aβ accumulation initiates the pathogenic cascades leading to AD, including the formation of neurofibrillary tangles, activation of astrocytes and neuronal loss. It has been well established that pathogenic mutations in both APP and PS genes contribute to AD pathogenesis via impaired generation of Aβ. This powerful genetic discovery lends great credence to the “Amyloid hypothesis”, given that APP is the precursor of Aβ and PS acts as the enzyme to generate Aβ. The thorough understanding of the mechanism of these pathogenic mutations could lead to decipher the AD conundrum. Until now, all pathogenic APP mutations are autosomal dominant mutations except for APPA673V. We discovered that APPA673V structurally facilitates β-cleavage at Asp-1 site while inhibited the general APP processing including all α-/β-/γ-cleavages possibly due to the intensified lysosome-dependent degradation. The overall effect of APPA673V on the production of Aβ makes the homozygous state necessary for APPA673V to produce enough Aβ to initiate AD pathogenesis. Mutations in PS genes are another major cause of FAD. As another substrate of γ-secretase apart from APP, Notch plays a fundamental role in neurodevelopment and neurodegeneration. It has been well established that pathogenic PS mutations impaired Notch signaling. PS1ΔS169 is a recently discovered PS1 mutation in a Chinese FAD family. We extensively characterized the function of PS1ΔS169 in mammalian cells and transgenic mice and found that PS1ΔS169 promoted AD pathogenesis via altering γ-cleavage of APP without impairing Notch processing, excluding the contribution of Notch signaling to AD pathogenesis. Our study highlights the possibility of developing specific γ- secretase inhibitors, which may spare Notch signaling in AD therapy.
Serica MacLeay 1819
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Serica

description: Serica MacLeay, 1819
[403 species and 13 additional subspecies].
Type species Scarabaeus brunneus Linnaeus, 1758 (as brunnus), by monotypy.
Melolontha (Stilbolemma) Harris, 1827.
Type species Melolontha vespertina Gyllenhal, 1817, by subsequent designation of Evans (2003).
Synonymy by Dalla Torre (1912a).
Camptorhina Kirby, 1837.
Type species Camptorhina atracapilla Kirby, 1837, by monotypy.
Synonymy by Harold (1869b).
Trichoserica Reitter, 1896.
Type species Trichoserica fulvopubens Reitter, 1896, by original designation.
Synonymy by Nomura (1972).
Serica (Odontoserica): Kolbe 1897.
Unavailable name.
Serica (Ophthalmoserica) Brenske, 1898c.
Type species Serica (Ophthalmoserica) thibetana Brenske, 1897, by subsequent designation of Ahrens (1999).
Synonymy by Arrow (1946b).
Podoserica Breit, 1912. Type species Podoserica reitteri Breit, 1912, by monotypy. Synonymy by Ahrens (2005).
Maladera (Paramaladera) Nikolajev, 1979 (not Paramaladera Nomura, 1974).
Type species Serica alternata LeConte, 1856, by original designation.
Synonymy by Harpootlian (2001).
Serica (Taiwanoserica) Nomura, 1974, as Taiwanoserica.
Type species Taiwanoserica elongata Nomura, 1974, by original designation.
Status revised to Serica (Taiwanoserica) by Ahrens (2007b).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 146, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
A reduction in the UHE neutrino flux due to neutrino spin precession
Creators: name: Barranco, J.
name: Miranda, O. G.
name: Moura, C. A.
name: Parada, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Motivated by the stringent flux limits for UHE neutrinos coming from gamma ray burst or active galactic nuclei, we explore the possibility that the active neutrinos generated in such astrophysical objects could oscillate to sterile right handed states due to a neutrino magnetic moment mu_nu. We find that a value as small as mu_nu ~1E-15 mu_B could produce such a transition thanks to the intense magnetic fields that are expected in these objects.
description: 5 pages, 1 figure, to appear in Physics Letters B
Aproximação inicial de descritores para realização de revisão de literatura: o termo professor editor.
Creators: name: Nolasco, Marcelo
name: Pinto Nunes, Claudio
Publisher: name: figshare
Year: 2021
Subjects: subject: 130304 Educational Administration, Management and Leadership
subject: FOS: Educational sciences

description: Trabalho apresentado durante o VIII Seminário Nacional e IV Seminário Internacional - Seminário Gepráxis: Políticas Públicas, Gestão e Práxis Educacional -25 a 28 de maio de 2021.
A Comparison of Surgical Outcome of Major Pancreatic Resections: Left Pancreatectomy Versus Pancreaticoduodenectomy
Creators: name: Ariotti, Riccardo
name: Pecorelli, Nicolò
name: Capretti, Giovanni
name: Carvello, Michele
name: Gilardini, Cristina
name: Castoldi, Renato F
name: Braga, Marco
name: Staudacher, Carlo
name: Balzano, Gianpaolo
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context Left pancreatectomy (LP) is considered a minor operation, when compared to pancreatico­duodenectomy (PD), due to a technically easier resection, without the burden of pancreatic anastomosis. Nonetheless LP is a demanding procedure with high blood loss and a high rate of postoperative pancreatic fistula. Objective To compare surgical outcome between patients undergoing PD and LP in a high volume institution. Methods Retrospective study on prospectively collected data on 981 consecutive patients undergoing PD (n=664) and LP (n=317), between 2004 and 2011. Postoperative complications were stratified according to Clavien-Dindo classifications (major complications III-V). Pancreatic fistula (PF) was defined according to ISGPF classifications. Results Mortality was higher in PD (3.6% vs. 0.3%, P<0.001), but overall morbidity was the same (63% in both groups). Postoperative major complications were more frequently in PD group (18.4% vs. 5.3%, P<0.001). PF was more frequent in LP (PD 30% vs. LP 46%, P<0.001); however, clinically significant grade B and C PF rate was higher in PD (16% vs. 6%, P<0.001).  Intraoperative blood loss was similar between groups (PD 568±388 mL, LP 619±685 mL, P=0.169), however the rate of patients who received a blood transfusion intraoperatively was higher in the PD group (35% vs. 22%, P<0.001). This was probably due to a higher number of patients presenting with preoperative anemia (mean hemoglobin: PD 12.4±2.2 g/dL vs. LP 13.2±1.7 g/dL, P<0.001). PD patients were transfused more postoperatively (20% vs. 11%, P<0.001) and had a higher mean volume of postoperative transfusion (232±811 mL vs. 79±281 mL, P<0.001). Conclusion As expected, mortality and major complications were higher after PD. Overall morbidity and intraoperative blood loss were similar between the two operations.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer.
Creators: name: Bentham, Robert
name: Jones, Thomas P
name: Black, James RM
name: Martinez-Ruiz, Carlos
name: Dietzen, Michelle
name: Litovchenko, Maria
name: Thol, Kerstin
name: Watkins, Thomas BK
name: Bailey, Chris
name: Pich, Oriol
name: Zhang, Zhihui
name: Van Loo, Peter
name: Consortium, TRACERx
name: Consortium, Genomics England
name: Swanton, Charles
name: McGranahan, Nicholas
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology

description: Recognition and elimination of pathogens and cancer cells depend on the adaptive immune system. Thus, accurate quantification of immune subsets is vital for precision medicine. We present immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell and B cell fractions, class switching and clonotype diversity from whole-genome sequencing data at depths as low as 5× coverage. By applying ImmuneLENS to the 100,000 Genomes Project, we identify genes enriched with somatic mutations in T cell-rich tumors, significant sex-based differences in circulating T cell fraction and demonstrated that the circulating T cell fraction in patients with cancer is significantly lower than in healthy individuals. Low circulating B cell fraction was linked to increased cancer incidence. Finally, circulating T cell abundance was more prognostic of 5-year cancer survival than infiltrating T cells.
p-adic congruences motivated by series
Creators: name: Sun, Zhi-Wei
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 11B65, 11A07, 11B68, 05A10, 05A19, 11S99

description: Let $p>5$ be a prime. Motivated by the known formulae $\sum_{k=1}^\infty(-1)^k/(k^3\binom{2k}{k})=-2ζ(3)/5$ and $\sum_{k=0}^\infty \binom{2k}{k}^2/((2k+1)16^k)=4G/π$$ (where $G=\sum_{k=0}^\infty(-1)^k/(2k+1)^2$ is the Catalan constant), we show that $$\sum_{k=1}^{(p-1)/2}\frac{(-1)^k}{k^3\binom{2k}{k}}\equiv-2B_{p-3}\pmod{p},$$ $$\sum_{k=(p+1)/2}^{p-1}\frac{\binom{2k}{k}^2}{(2k+1)16^k}\equiv-\frac 7{4}p^2B_{p-3}\pmod{p^3}$$, and $$\sum_{k=0}^{(p-3)/2}\frac{\binom{2k}{k}^2}{(2k+1)16^k} \equiv-2q_p(2)-pq_p(2)^2+\frac{5}{12}p^2B_{p-3}\pmod{p^3},$$ where $B_0,B_1,\ldots$ are Bernoulli numbers and $q_p(2)$ is the Fermat quotient $(2^{p-1}-1)/p$.
description: 15 pages, final published version
Sericania Motschulsky 1860
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Sericania

description: Sericania Motschulsky, 1860
[54 species and additional subspecies].
Type species Sericania fuscolineata Motschulsky, 1860, by monotypy.
Note: Motschulsky (1860) spelt the genus as Sericaria (p. 136) and Sericania (pp. 137, 256); the latter is in prevailing usage.
Sericania (Mesoserica) Matsumura, 1911 (not Mesoserica Brenske, 1897).
Type species Sericania (Mesoserica) sachalinensis Matsumura, 1911, by monotypy.
Synonymy by Kobayashi (1974).
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 147, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Constraints on general second-order scalar-tensor models from gravitational Cherenkov radiation
Creators: name: Kimura, Rampei
name: Yamamoto, Kazuhiro
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We demonstrate that the general second-order scalar-tensor theories, which have attracted attention as possible modified gravity models to explain the late time cosmic acceleration, could be strongly constrained from the argument of the gravitational Cherenkov radiation. To this end, we consider the purely kinetic coupled gravity and the extended galileon model. In these models, the propagation speed of tensor mode could be less than the speed of light, which puts very strong constraints from the gravitational Cherenkov radiation.
description: 9 pages, 2 figures, v2: published in JCAP
Setiserica Miyake 2002
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Setiserica

description: Setiserica Miyake in Miyake et al., 2002
[2 species].
Type species Setiserica pygmaea Miyake, Yamaguchi & Akiyama, 2002, by original designation.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 147, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
Post-Pancreatectomy Hemorrhage: Management, Outcome and Predicting Factors of a Life-Threatening Complication
Creators: name: Pecorelli, Nicolò
name: Ariotti, Riccardo
name: Capretti, Giovanni
name: Carvello, Michele
name: Gilardini, Cristina
name: Castoldi, Renato F
name: Braga, Marco
name: Staudacher, Carlo
name: Balzano, Gianpaolo
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context Hemorrhagic complications are life-threatening complications occurring after pancreatectomy. Objectives 1. To analyze incidence, management, and clinical outcome of post-pancreatectomy hemorrhage (PPH). 2. To identify factors associated with its occurrence. Methods Retrospective study on prospectively collected data about 981 consecutive patients undergoing a standard pancreatic resection (pancreaticoduodenectomy or left pancreatectomy) between 2004 and 2011. PPH was defined as postoperative clinical or radiological evidence of bleeding, requiring transfusion of packed red blood cells. PPH was stratified based on: time of onset (early: within 24 hr after surgery; late >24 hr); site (intraluminal: in the GI tract; or extraluminal); severity (mild: self-limiting with no need for radiologic or surgical intervention; severe: requiring intervention). Results A total of 65 patients (6.6%) experienced PPH. It was early in 17 (26%) and late in 48 (74%) patients. In 9 cases (14%) PPH was intraluminal, in 56 (86%) extraluminal. In 14 patients (21%) PPH was mild; angiography (with embolization or stenting) was used in 9 patients (14%), and it was successful in 5 patients; the remaining 4 patients needed further radiological or surgical treatment. Relaparotomy for PPH was necessary in overall 49 patients (75%). Mean volume of postoperative transfusion was 1,847±1,997 mL. Re-bleeding after radiological or surgical intervention occurred in 10 patients (15%). Overall mortality in patients with PPH was 45%. Factors predicting PPH were type of surgery (pancreaticoduodenectomy), soft pancreatic stump, and postoperative pancreatic fistula. Conclusion PPH can be a dramatic complication, frequently leading to relaparotomy, and carries a high risk of mortality.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
Video-Enhanced Dialogic Assessment: Online Vivas for teacher assessment
Creators: name: Hidson, Elizabeth
Publisher: name: Edge Hill University
Year: 2021
Subjects: subject: 130313 Teacher Education and Professional Development of Educators
subject: FOS: Educational sciences
subject: 130103 Higher Education

description: Presentation about online vivas for teacher assessment - the Video-Enhanced Dialogic Assessment process at The University of Sunderland.
MALDI-TOF/MS Biomarkers Discovery for Pancreatic Cancer Diagnosis: Emerging Role of Apolipoprotein A1 and Complement C3
Creators: name: Padoan, Andrea
name: Seraglia, Roberta
name: Fogar, Paola
name: Sperti, Cosimo
name: Moz, Stefania
name: Greco, Eliana
name: Marchet, Alberto
name: Zambon, Carlo Federico
name: Navaglia, Filippo
name: Di Chiara, Alda
name: Nitti, Donato
name: Pedrazzoli, Sergio
name: Pavanello, Girolamo
name: Pasquali, Claudio
name: Plebani, Mario
name: Basso, Daniela
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context New serum biomarkers are needed for pancreatic cancer (PCa) diagnosis especially among patients with diabetes mellitus (DM), a risk factor for and a consequence of PCa. Objective To validate new serum biomarkers identified by MALDI-TOF/MS for PCa diagnosis. Methods MALDI-TOF/MS analysis was performed in sera from 22 controls, 51 PCa, 37 chronic pancreatitis (ChrPa), 24 DM, 29 gastric cancer (GC), and 24 chronic gastritis (CG). Results Eleven out of 160 selected features (m/z range 1,200-5,000) were highly correlated with pancreatic diseases (univariate and binary recursive partitioning tree analyses). By MALDI-TOF-TOF analysis three features (1,530, 1,550, 1,778 m/z) were found to be part of clusterin, human apolipoprotein A1 (Apo-A1), and human complement C3, respectively. Apo-A1 and C3 were measured in 172/187 sera and in an additional series of 69 new samples yielding 30 controls, 81 PCa, 26 ChrPa, 51 DM, 32 GC, 21 CG. Apo-A1 was reduced in PCa and in GC (F=10.49, P<0.0001). In 22/81 (27.2%) PCa and in 2/32 (6.2%) GC Apo-A1 values were below 0.6 g/L, while values in this order of magnitude were never found in the other groups (100% specificity). Apo-A1, C3 and CA 19-9 were correlated with PCa diagnosis at univariate logistic regression analysis; at multivariate logistic regression only Apo-A1 (OR=0.38, 95% CI=0.17-0.86, P=0.020) and C3 (OR=4.75, 95% CI=2.33-9.67, P<0.001) were confirmed to be strictly correlated with PCa. Conclusion Reduced serum levels of the anti-inflammatory and antioxidant protein Apo-A1, major protein in HDL, and increased serum levels of the inflammatory mediator C3 are potential biomarkers for PCa.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
S100A8 and S100A9 Target Akt, mTOR and NF-kB Signalling in Pancreatic Cancer Cells
Creators: name: Moz, Stefania
name: Bozzato, Dania
name: Padoan, Andrea
name: Zambon, Carlo Federico
name: Fogar, Paola
name: Sperti, Cosimo
name: Greco, Eliana
name: Navaglia, Filippo
name: Pelloso, Michela
name: Rossi, Elisa
name: Pasquali, Claudio
name: Pedrazzoli, Sergio
name: Plebani, Mario
name: Basso, Daniela
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context S100A8/S100A9 inflammatory proteins are suggested to be involved in pancreatic cancer (PaCa) progression. S100A8/A9 expression in the neoplastic pancreas correlate with SMAD4 mutational status suggesting possible interactions with TGF-b1. Objective To ascertain whether S100A8/S100A9 differently affect Akt, mTOR and NF-kB signalling in PaCa cells with different aggressiveness and whether these molecules interact with TGF-b1. Methods Western blotting analyses were used to assess the effects of S100A8, S100A9 and S100A8/A9 on Akt (Ser473, Thr308), mTOR (Ser2448) and NF-kB (p-IkB-a) in BxPC3, Capan1 and MiaPaCa2 PaCa cells lines. S100A8, S100A9, S100A8/A9 were incubated with equimolar concentrations of calcium and TGF-b1 for 24 h at 37°C. Following MALDI-TOF-MS analyses were performed. Results In BxPC3 Akt Thr308 was phosphorylated by S100A8/A9, while in Capan1 and MiaPaCa2 S100A8/A9, S100A8 and S100A9 phosphorylated both Akt sites. In Capan1 and MiaPaCa2, not in BxPC3, S100A8, S100A9 and S100A8/A9 caused significant Ser2448 phosphorylation. S6RP, downstream effector of mTORC1, was phosphorylated (Ser235/236) only in S100A8 treated MiaPaCa2. A strong NF-kB activation was induced by S100A8 in BxPC3, by S100A9 and S100A8/A9 in Capan1. NF-kB was inhibited by S100A8 and S100A8/A9, while it was activated by S100A9 in MiaPaCa2. In the presence of TGF-b1 S100A8/A9 effects on Akt Thr308 and Ser473 phosphorylation were significantly modified, sug­gesting the existence of interactions between TGF-b1 and S100A8/A9. In the presence of calcium ions S100A8 and S100A9 formed, as expected, homo- (21663 m/z and 28346 m/z) and hetero- (25153 m/z) dimers (MALDI-TOF-MS). An absolute new finding was the identification of hetero-complexes formed by S100A9 and TGF-b1 (39803 m/z). Conclusion S100A8/A9 proteins in pancreatic cancer might favour cancer cell growth by inducing Akt, mTOR and NF-kB. In the less invasive BxPC3 cells S100A8 activates NF-kB. In more aggressive Capan1 and MiaPaCa2 cells S100A8, S100A9 and S100A8/A9 activate mainly Akt and mTORC1, not NF-kB pathways. TGF-b1 was demonstrated to be a new binding partner of S100A9 and this will open new fields of investigation on these interesting and complex inflammatory proteins in the PaCa setting.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
L-infinity algebra actions
Creators: name: Mehta, Rajan
name: Zambon, Marco
Publisher: name: arXiv
Year: 2012
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 58A50, 17B66, 16W25, 53D17

description: We define the notion of action of an L-infinity algebra $g$ on a graded manifold $M$, and show that such an action corresponds to a homological vector field on $g[1] \times M$ of a specific form. This generalizes the correspondence between Lie algebra actions on manifolds and transformation Lie algebroids. In particular, we consider actions of $g$ on a second L-infinity algebra, leading to a notion of "semidirect product" of L-infinity algebras more general than those we found in the literature.
description: v2: Final version, to appear in Diff. Geom. Appl
Exact completions and small sheaves
Creators: name: Shulman, Michael
Publisher: name: arXiv
Year: 2012
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 18B25

description: We prove a general theorem which includes most notions of "exact completion". The theorem is that "k-ary exact categories" are a reflective sub-2-category of "k-ary sites", for any regular cardinal k. A k-ary exact category is an exact category with disjoint and universal k-small coproducts, and a k-ary site is a site whose covering sieves are generated by k-small families and which satisfies a weak size condition. For different values of k, this includes the exact completions of a regular category or a category with (weak) finite limits; the pretopos completion of a coherent category; and the category of sheaves on a small site. For a large site with k the size of the universe, it gives a well-behaved "category of small sheaves". Along the way, we define a slightly generalized notion of "morphism of sites", and show that k-ary sites are equivalent to a type of "enhanced allegory".
description: v2: 77 pages; added discussion of postulated and lex colimits; final version, has appeared in TAC
Ellipsoidal billiards in pseudo-Euclidean spaces and relativistic quadrics
Creators: name: Dragovic, Vladimir
name: Radnovic, Milena
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study geometry of confocal quadrics in pseudo-Euclidean spaces of an arbitrary dimension $d$ and any signature, and related billiard dynamics. The goal is to give a complete description of periodic billiard trajectories within ellipsoids. The novelty of our approach is based on introduction of a new discrete combinatorial-geometric structure associated to a confocal pencil of quadrics, a colouring in $d$ colours, by which we decompose quadrics of $d+1$ geometric types of a pencil into new relativistic quadrics of $d$ relativistic types. Deep insight of related geometry and combinatorics comes from our study of what we call discriminat sets of tropical lines $Σ^+$ and $Σ^-$ and their singularities. All of that enable usto get an analytic criterion describing all periodic billiard trajectories, including the light-like ones as those of a special interest.
description: 29 pages, 7 figures
Somatoserica Brenske 1899
Creators: name: Allsopp, Peter G.
name: Schoolmeesters, Paul
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Somatoserica

description: Somatoserica Brenske, 1899c
[1 species].
Type species Somatoserica sikorae Brenske, 1899, by monotypy.
description: Published as part of Allsopp, Peter G. & Schoolmeesters, Paul, 2024, All genera of the world: Subfamilies Prototroginae, Cretoscarabaeinae, Dynamopodinae, Electrorubesopsinae, Phaenomeridinae, Orphninae, Allidiostomatinae, Aclopinae, Lichniinae, Melolonthinae, Oncerinae, Podolasiinae, Sericinae, Sericoidinae (Animalia: Arthropoda: Insecta: Coleoptera: Scarabaeidae), pp. 104-175 in Megataxa 12 (1) on page 147, DOI: 10.11646/megataxa.12.1.2, http://zenodo.org/record/14984437
$QD$-Learning: A Collaborative Distributed Strategy for Multi-Agent Reinforcement Learning Through Consensus + Innovations
Creators: name: Kar, Soummya
name: Moura, Jose' M. F.
name: Poor, H. Vincent
Publisher: name: arXiv
Year: 2012
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Multiagent Systems (cs.MA)
subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The paper considers a class of multi-agent Markov decision processes (MDPs), in which the network agents respond differently (as manifested by the instantaneous one-stage random costs) to a global controlled state and the control actions of a remote controller. The paper investigates a distributed reinforcement learning setup with no prior information on the global state transition and local agent cost statistics. Specifically, with the agents' objective consisting of minimizing a network-averaged infinite horizon discounted cost, the paper proposes a distributed version of $Q$-learning, $\mathcal{QD}$-learning, in which the network agents collaborate by means of local processing and mutual information exchange over a sparse (possibly stochastic) communication network to achieve the network goal. Under the assumption that each agent is only aware of its local online cost data and the inter-agent communication network is \emph{weakly} connected, the proposed distributed scheme is almost surely (a.s.) shown to yield asymptotically the desired value function and the optimal stationary control policy at each network agent. The analytical techniques developed in the paper to address the mixed time-scale stochastic dynamics of the \emph{consensus + innovations} form, which arise as a result of the proposed interactive distributed scheme, are of independent interest.
description: Submitted to the IEEE Transactions on Signal Processing, 33 pages
title: War Losses (Australia)
title: War Losses (Australia)
Creators: name: Noonan, David C.
Publisher: name: BSB - Bavarian State Library
Year: 2016
Subjects: subject: o.P. Australien
subject: Weltkrieg [1914-1918]
subject: Kriegsverlust
subject: o.P. World War, 1914-1918--Australia
subject: War casualties

description: The official numbers of casualties suffered by the Australian Imperial Force (AIF) in the First World War are underestimated in multiple categories. These official figures comprise the limited statistics of 60,000 dead and 155,000 woundings, impacting upon a purported 331,000, mainly civilian volunteers, who went to war. These statistics are significantly limited because, contrary to international convention, they omit hospitalisations for all injury and any for illness and substantially understate admissions for shell shock. However, ground-breaking statistical analysis, completed in the centennial 2014, has now revealed the extent of premature post-war death, and that the total hospital admissions for wounding, injury and illness suffered by the men of the AIF exceeded 750,000.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
title: McAdoo, William Gibbs
title: McAdoo, William Gibbs
Creators: name: Huibregtse, Jon
Publisher: name: BSB - Bavarian State Library
Year: 2016
Subjects: subject: o.P. McAdoo, William Gibbs
subject: o.P. McAdoo, W. G. (William Gibbs), 1863-1941

description: William G. McAdoo was an American politician and businessman. During World War I, he served as Secretary of the Treasury and director of the US Railroad Administration. In these positions he was the architect of the USA's wartime financial planning and responsible for keeping its largest railroads operating efficiently.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Charged-Particle Decay at Finite Temperature
Creators: name: Czarnecki, Andrzej
name: Kamionkowski, Marc
name: Lee, Samuel K.
name: Melnikov, Kirill
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Radiative corrections to the decay rate of charged fermions caused by the presence of a thermal bath of photons are calculated in the limit when temperatures are below the masses of all charged particles involved. The cancellation of finite-temperature infrared divergences in the decay rate is described in detail. Temperature-dependent radiative corrections to a two-body decay of a hypothetical charged fermion and to electroweak decays of a muon are given. We touch upon possible implications of these results for charged particles in the early Universe.
description: 18 pages, 6 figures. v2: typos corrected, bibliography revised, content matches published version
Microtubules immuno-labeled with Alexa 647 with widefield images 76-80
Creators: name: SINGH, Manish
Publisher: name: Zenodo
Year: 2021
Subjects: shareloc.xyz
shareloc.xyz:dataset
dstorm
u373
microtubules
alexa-647
indirect-immuno-labeling
alpha-tubulin
2d
em-ccd
thunderstorm
gluox
pfa+gluta
smlm

description: Open in Shareloc.XYZ

description: dSTORM images of microtubules with widefield images, Alpha-tubulin immuno-labeled with Alexa 647 in U373 cells, reconstructed by ThunderSTORM plugin (Uploaded via https://shareloc.xyz)
Mechanisms for XIST RNA cis-localisation
Creators: name: Kelsey, Angela
Publisher: name: University of British Columbia
Year: 2013

description: X inactivation is the process of silencing one of the two X chromosomes in mammalian female cells in order to equalise the dosage of X-linked genes with males. The process is initiated by the long noncoding RNA XIST, which is transcribed from the future inactive X and localises to it in cis. How XIST RNA is able to localise to the X chromosome is not well defined. The aim of the current study was to deduce mechanisms of XIST RNA localisation. This was addressed in various ways, including 1) testing the ability of an XIST transgene integrated into a variety of autosomes to localise to those autosomes, as opposed to the X chromosome; 2) assessing the ability of XIST transgenes with different regions deleted to localise, in order to identify sequences required for localisation; and 3) knocking down various proteins implicated in X inactivation in order to assess any effect on the ability of XIST to localise. We find that the XIST transgene is able to localise to a wide variety of different autosomes and furthermore, is able to direct the enrichment of the histone variant macroH2A on an autosome and the deposition of a repressive histone modification, H3K27me3, onto an autosome. We also find that a region of XIST encompassing repeats B and C, and sequences downstream of exon 1 are involved in localising XIST RNA, and that they do so in a redundant fashion. Lastly, we show that the knockdown of five proteins - YY1, hnRNP-U, SPOP, CUL3 and ASH2L - prevent the formation of an intact XIST focus. The results presented here add to the limited knowledge of how XIST RNA is able to localise, an essential step in the process of X chromosome inactivation.
Hymenogadus tenuis
Creators: name: Schwarzhans, Werner
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gadiformes
Macrouridae
Hymenogadus
Hymenogadus tenuis

description: Hymenogadus tenuis (Gilbert & Hubbs, 1917)
Figs. 6J–L, 7
 Hymenocephalus tenuis Gilbert & Hubbs, 1917: 173 (type locality: Hawaii, off southern Oahu).
 Material examined. The unique holotype: USNM 78177, 75 mm TL, south coast of Oahu, Hawaii, 485–512 m, Albatross, 5 June 1902.
 Diagnosis. Pelvic fin rays 8; pectoral fin rays 12; barbel short, 12% HL, reaching vertical through anterior edge of orbit; gill rakers 10; OL:OH = 1.3, from x-ray.
 Comparison. See H. gracilis.
 Description. Head morphology (Fig. 6J–K): Head slender with projecting, broad, soft-tipped snout. No scale pockets visible on head, but present on nape. Snout length 20% HL, orbit diameter 38% HL, interorbital width 40% HW. Barbel 12% HL, reaching vertical through anterior edge of orbit. Frontal, infraorbital, supraorbital and postorbital canals widened (infraorbital, supraorbital and postorbital widths 5–12% HL), covered by thin, but mostly preserved skin; preopercular and supratemporal canals fully skin covered and indistinct. Infranasal supporter small; infraorbital supporter narrow, not expanded below rear part of orbit; preopercular supporter narrow, pointed, short, 4% HL. No pores visible.
 Otolith morphology (Fig. 6L): No otolith was extracted from the unique holotype, but a high quality x-ray shows an otolith with a very similar outline and similar proportions (OL:OH = 1.3) to those of H. gracilis, but seemingly with a more symmetrical and not-inclined predorsal lobe.
 Distribution (Fig. 7). Apparently endemic to Hawaii.
description: Published as part of Schwarzhans, Werner, 2014, Head and otolith morphology of the genera Hymenocephalus, Hymenogadus and Spicomacrurus (Macrouridae), with the description of three new species, pp. 1-73 in Zootaxa 3888 (1) on page 26, DOI: 10.11646/zootaxa.3888.1.1, http://zenodo.org/record/10086415
title: Robertson, William Robert
title: Robertson, William Robert
Creators: name: Woodward, David R.
Publisher: name: BSB - Bavarian State Library
Year: 2016
Subjects: subject: o.P. Robertson, William Robert
subject: o.P. Robertson, W. R. (William Robert), 1860-1933

description: William Robert Robertson was the first British soldier to advance from private to field marshal. During the Great War, he initially served as the British Expeditionary Force’s quartermaster-general before becoming its Chief of staff in January 1915. In December 1915, he became the government’s designated military adviser as chief of the Imperial General Staff, holding that position until February 1918 when he was forced out, primarily because of his unyielding support of Sir Douglas Haig in concentrating British forces in the killing fields of France and Belgium.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
title: Intimate Relations between Occupiers and Occupied (Belgium and France)
title: Intimate Relations between Occupiers and Occupied (Belgium and France)
Creators: name: Debruyne, Emmanuel
Publisher: name: BSB - Bavarian State Library
Year: 2016
Subjects: subject: o.P. Weltkrieg [1914-1918]
subject: Sexualverhalten
subject: o.P. World War, 1914-1918
subject: Sexual behavior

description: During the invasion and occupation of 1914-1918, German soldiers had sexual relations with local women in Belgium and France. There were many cases of rape during the invasion, but the occupation itself was more characterized by a rise in prostitution. Other forms of intimate relations also emerged, but they generally did not outlast the war itself.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
NMR and MRCP After Secretin Infusion in a Long-Term Comparison Study of Pancreogastro- vs. Pancreojejuno-Duodenopancreatectomy
Creators: name: Cristofori, Chiara
name: Amodio, Antonio
name: Sozzi, Carlo
name: Cardobi, Nicolò
name: Rostello, Anna
name: Ruffini, Martina
name: Butturini, Giovanni
name: Salvia, Roberto
name: Campagnola, Pietro
name: Gabbrielli, Armando
name: Manfredi, Riccardo
name: Frulloni, Luca
name: Bassi, Claudio
name: Vantini, Italo
name: Benini, Luigi
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context After pylorus-preserving pancreaticoduodenectomy the anastomosis of pancreatic remnant may be done with the stomach (pancreogastric, PGA) or the jejunum (pancreojejunum, PJA). Recently, we have found that, in the long-term, PGA is associated with a more severe impairment of the residual pancreatic function. No data are available on the RNM ability to demonstrate an impairment of the residual pancreatic secretion or morphological changes after surgery. Methods Patients who 6 years ago entered a controlled short term comparison of PGA and PJA were studied by RNM and MRCP after secretin infusion (quantification of residual pancreatic volume, pancreatic duct diameter immediately proximal to the anastomosis, qualitative impairment of secretion), and tests of exocrine (fecal elastase-1, fecal fat balance) function. Two radiologists, blinded to the results of functional parameters, independently scored the residual pancreatic volume, duct diameter and secretin-stimulated secretion. Mean±SEM are shown. The Student’s t test was used. Results We studied 34 patients (16 PGA, 18 PJA; age 56.6±2.7 vs. 57.5±2.5 years; time from surgery 81±5 vs. 80±3 months). PGA was associated with a more severe impairment of steatorrhea than PJA (26.6±4.1 vs. 18.2±3.6 g/day; reference range: 0-7; P<0.01) and of fecal elastase-1 (70.2±25.5 vs. 121.4±6.7 µg/g; P<0.001). RNM showed in PGA a more marked dilatation of the pancreatic duct (diameter 4.63±0.91 vs. 2.50±0.18 mm, P<0.05) and non significant tendency to a smaller residual pancreas (26.3±3.0 vs. 35.9±4.1 mL; P=0.069). There is a power correlation between residual pancreas and steatorrhea. After secretin infusion, the secretion was consistently considered by two different radiologists to be more frequently impaired in PGA (42%) than in PJA (18%; P=0.05, Fisher test). Conclusion The pancreo-gastric anastomosis is associated, in the long run, with more severe morphological and functional impairment of exocrine function than the pancreo-jejunal one.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650
title: Weddigen, Otto Eduard
title: Weddigen, Otto Eduard
Creators: name: Jones, Mark
Publisher: name: BSB - Bavarian State Library
Year: 2016
Subjects: subject: o.P. Weddigen, Otto

description: Otto Weddigen was among the best-known German submarine commanders in the First World War. He died in March 1915 after HMS Dreadnought rammed and sank his submarine as it undertook a failed attack on the British military harbour at Scapa Flow. He remained an important German war hero for the duration of the conflict.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Growth from Below: Bilayer Graphene on Copper by Chemical Vapor Deposition
Creators: name: Nie, Shu
name: Wu, Wei
name: Xing, Shirui
name: Yu, Qingkai
name: Bao, Jiming
name: Pei, Shin-shem
name: McCarty, Kevin F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We evaluate how a second graphene layer forms and grows on Cu foils during chemical vapor deposition (CVD). Low-energy electron diffraction and microscopy is used to reveal that the second layer nucleates and grows next to the substrate, i.e., under a graphene layer. This underlayer mechanism can facilitate the synthesis of uniform single-layer films but presents challenges for growing uniform bilayer films by CVD. We also show that the buried and overlying layers have the same edge termination.
description: Revised after review. Accepted for publication in New Journal of Physics
title: Interventionism (Italy)
title: Interventionism (Italy)
Creators: name: Prezioso, Stéfanie
Publisher: name: BSB - Bavarian State Library
Year: 2016
Subjects: subject: o.P. Italien
subject: Interventionismus
subject: Weltkrieg [1914-1918]
subject: o.P. Italy--Politics and government--1870-1914

description: Italy entered the First World War in May 1915, roughly ten months after it began. During those ten months, the battle of opinions for and against intervention raged on. Public meetings, demonstrations, and street clashes that occasionally left partisans of neutrality (socialists, Catholics and liberals close to Giovanni Giolitti) wounded put the debate in the public eye.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Massively Parallel Sequencing Analysis of Genetic Alterations Carried by Pancreatic Adenocarcinoma
Creators: name: Macchini, Marina
name: Astolfi, Annalisa
name: Casadei, Riccardo
name: Indio, Valentina
name: Vecchiarelli, Silvia
name: Ricci, Claudio
name: D’Ambra, Marielda
name: Grassi, Elisa
name: Santini, Donatella
name: Serra, Carla
name: Pezzilli, Raffaele
name: Minni, Francesco
name: Biasco, Guido
name: Di Marco, Mariacristina
Publisher: name: JOP. Journal of the Pancreas
Year: 2012
Subjects: Meeting Abstracts; Pancreas

description: Context Pancreatic cancer (PC) is characterized by a 5-year survival rate of 4%. The molecular mechanisms involved in the high tumorigenicity of PC are not yet well-known. Methods PC samples from 7 localized and advanced cases of pancreatic adenocarcinomas were collected by ultrasound-guided biopsy. Whole transcriptome RNA libraries were sequenced at 75x2 bp on a HiScanSQ Illumina platform. An average of 4.5x107 reads per sample were generated, with a mean read depth of 40. Sequences were mapped to the human genome (build hg19) and the single nucleotide variants (SNVs) were detected with SNVMix2 tool. The SNVs were compared with genetic variations databanks (dbSNP, 1000genomes, Cosmic) in order to highlight the novel variants. The non-synonimous SNVs were considered at the protein level and analyzed with SNPs&GO, in order to predict whether a variation is disease-related or neutral. Results Pancreatic adenocarcinomas exhibited a mean of 139 (range: 65-252) non-synonimous SNVs, of which 12 on average are potentially disease-related. We found mutations in oncogenes and tumor suppressor genes known to be related to pancreatic tumors, as 4/7 patients exhibited KRAS oncogenic variants (p.G12D, R or V) two of which carried also mutations either in SMAD4 or PIK3CA, one patient showed both TP53 and CDKN2A inactivating mutations and one a mutation in SMARCA4. Novel disease-related SNVs were found in genes regulating cell cycle progression and proliferation, apoptosis, TGFbeta and integrin-signaling, epithelial to mesenchymal transition and nucleotide excision repair. Of interest some genes were mutated in multiple patients, as CBLC that regulates intracellular signalling by multiple tyrosine kinase genes. Conclusions Next generation sequencing analysis, through the identification of the oncogenic alterations carried by tumor cells, can improve the understanding of pancreatic carcinogenesis and highlight new biomarkers for early diagnosis and potential therapeutic targets in pancreatic cancer.
description: JOP. Journal of the Pancreas, Vol 13, N° 5S (2012): September (Suppl.) - p. 548-650