title: ÐÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¼Ð¾Ð»ÐµÐºÑÐ» Ð¿ÐµÐ¿ÑÐ¸Ð´Ð½Ð¾Ð¹ Ð¸ Ð½ÐµÐ¿ÐµÐ¿ÑÐ¸Ð´Ð½Ð¾Ð¹ Ð¿ÑÐ¸ÑÐ¾Ð´Ñ Ñ ÑÐµÐ»ÑÑ Ð¿Ð¾Ð¸ÑÐºÐ° Ð½Ð¾Ð²ÑÑ Ð°Ð½Ð°Ð»ÑÐ³ÐµÑÐ¸ÐºÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Conformational analysis of peptide and non-peptide molecules in order to find new analgetics
Creators: name: ÐÐ¾Ð¼Ð°ÑÐ¾Ð², ÐÐ²Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð½Ð¾ÑÐ¸ÑÐµÐ¿ÑÐ¸Ñ
Ð½Ð°ÑÑÐ¸ÐµÐ²ÑÐµ ÐºÐ°Ð½Ð°Ð»Ñ
Ð°Ð½Ð°Ð»ÑÐ³ÐµÑÐ¸ÐºÐ¸
Na/K-ÐÐ¢Ð¤Ð°Ð·Ð°
ÐÐÐÐ
ÑÐµÐ½Ð¸Ð±ÑÑ
Ð¼ÐµÑÐµÐ±ÑÑ
ÐºÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð·
Ð´Ð¾ÐºÐ¸Ð½Ð³
nociception
sodium channels
analgetics
Na/K-ATPase
GABA
phenibut
mephebut
conformational analysis
docking

description: ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð½ÑÑ ÑÑÑÑÐºÑÑÑ Ð½Ð° ÐºÐ°Ð½Ð°Ð» Nav1.8 Ð¸ Na,K-ÐÐ¢Ð¤Ð°Ð·Ñ Ð½Ð¾ÑÐ¸ÑÐµÐ¿ÑÐ¾ÑÐ°, Ð²ÑÐ·ÑÐ²Ð°ÑÑÐ¸Ñ Ð°Ð½Ð°Ð»ÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÑÐµÐºÑ. ÐÑÐ±ÑÐ°Ð½ Ð¼ÐµÑÐ¾Ð´ Ð¿Ð¾Ð»Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼Ð¾Ð»ÐµÐºÑÐ». ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð¿Ð¾Ð»Ð½ÑÐ¹ ÐºÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÐ´Ð° Ð¼Ð¾Ð»ÐµÐºÑÐ»-Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¾ÑÐ¾Ð² ÐÐÐÐ-ÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ (ÐÐÐÐ, ÑÐµÐ½Ð¸Ð±ÑÑ, Ð¼ÐµÑÐµÐ±ÑÑ) Ñ ÑÐµÐ»ÑÑ Ð¾Ð±ÑÑÑÐ½ÐµÐ½Ð¸Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾Ð± Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ð¸ Ð½Ð° ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¼ÐµÐ´Ð»ÐµÐ½Ð½ÑÑ Ð½Ð°ÑÑÐ¸ÐµÐ²ÑÑ ÐºÐ°Ð½Ð°Ð»Ð¾Ð² Nav1.8 Ð² Ð¼ÐµÐ¼Ð±ÑÐ°Ð½Ðµ Ð½Ð¾ÑÐ¸ÑÐµÐ¿ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð½ÐµÐ¹ÑÐ¾Ð½Ð°. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾ÑÐµÐ½ÐºÐ° Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½Ð¾ÑÑÐ¸ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¼ÐµÑÐ¾Ð´Ð°. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð´Ð¾ÐºÐ¸Ð½Ð³ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ ÑÐµÐ»Ð°ÑÐ½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° ÑÐ°Ð±Ð°Ð¸Ð½âCa2+ Ð² Ð°Ð»ÑÑÐ°1-ÑÑÐ±ÑÐµÐ´Ð¸Ð½Ð¸ÑÑ Na,K-ÐÐ¢Ð¤Ð°Ð·Ñ Ð¸ Ð¾ÑÐµÐ½ÐµÐ½Ð° Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ ÑÐ¾Ð³Ð¾, ÑÑÐ¾ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐ¹ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼ Ð»Ð¸Ð³Ð°Ð½Ð´-ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐ²ÑÐ·ÑÐ²Ð°Ð½Ð¸Ñ ÑÐºÐ°Ð·Ð°Ð½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð¾ÑÐ»Ð¸ÑÐ°ÐµÑÑÑ Ð¾Ñ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð° ÑÐ²ÑÐ·ÑÐ²Ð°Ð½Ð¸Ñ ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾Ð¹ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ ÑÐ°Ð±Ð°Ð¸Ð½Ð°. ÐÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´Ð°ÐµÑ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¾Ð± Ð¾ÑÑÑÑÑÑÐ²Ð¸Ð¸ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¾ÑÐ¾Ð² ÐÐÐÐ- ÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð½Ð° ÐºÐ°Ð½Ð°Ð» Nav1.8. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð´Ð¾ÐºÐ¸Ð½Ð³Ð° Ð³Ð¾Ð²Ð¾ÑÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ ÑÑÑÐµÐºÑ ÑÐ°Ð±Ð°Ð¸Ð½âCa2+ Ð¾ÑÐ»Ð¸ÑÐ°ÐµÑÑÑ Ð¾Ñ ÑÑÑÐµÐºÑÐ° ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾Ð³Ð¾ ÑÐ°Ð±Ð°Ð¸Ð½Ð°, ÑÑÐ¾ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´Ð°ÐµÑ Ð³Ð¸Ð¿Ð¾ÑÐµÐ·Ñ.
description: Researching of molecular mechanism of actions of several structures on Nav1.8 channel and Na,K-ATPase was performed. Method of full conformational molecule analysis was established. A full conformational analysis of several GABA-ergic system activators (GABA, phenibut, mephebut) was performed in order to explain the experimental data on their effect on the functioning of slow sodium channels Nav1.8 in the nociceptive neuron membrane. Reliability of established method was estimated. Docking of the chelate complex ouabainâCa2+ molecule to the alpha1- subunit of Na,K-ATPase was carried out, and a possibility that the molecular mechanism of ligand-receptor binding of this complex could be different from that of the free ouabain molecule was considered. Conformational analysis approves actual experimental data. Results of docking lead to supposing that ouabainâCa2+ varies from one of free ouabain, which approves hypothesis.