cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The influence of rare variants in circulating metabolic biomarkers.
Creators: name: Riveros-Mckay, Fernando
name: Oliver-Williams, Clare
name: Karthikeyan, Savita
name: Walter, Klaudia
name: Kundu, Kousik
name: Ouwehand, Willem H
name: Roberts, David
name: Di Angelantonio, Emanuele
name: Soranzo, Nicole
name: Danesh, John
name: Wheeler, Eleanor
name: Zeggini, Eleftheria
name: Butterworth, Adam S
name: Barroso, Inês
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy participants. We leveraged the information from multiple metabolite measurements on the same participants to improve discovery in rare variant association analyses for gene-based and gene-set tests by incorporating correlated metabolites as covariates in the validation stage. Gene-based analysis corrected for the effective number of tests performed, confirmed established associations at APOB, APOC3, PAH, HAL and PCSK (p<1.32x10-7) and identified novel gene-trait associations at a lower stringency threshold with ACSL1, MYCN, FBXO36 and B4GALNT3 (p<2.5x10-6). Regulation of the pyruvate dehydrogenase (PDH) complex was associated for the first time, in gene-set analyses also corrected for effective number of tests, with IDL and LDL parameters, as well as circulating cholesterol (pMETASKAT<2.41x10-6). In conclusion, using an approach that leverages metabolite measurements obtained in the same participants, we identified novel loci and pathways involved in the regulation of these important metabolic biomarkers. As large-scale biobanks continue to amass sequencing and phenotypic information, analytical approaches such as ours will be useful to fully exploit the copious amounts of biological data generated in these efforts.
Young drivers' responses to anti-speeding advertisements: Comparison of self-report and objective measures of persuasive processing and outcomes
Creators: name: Sherrie-Anne Kaye
name: Ioni Lewis
name: Algie, Jennifer
name: White, Melanie J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: Self-report measures are typically used to assess the effectiveness of road safety advertisements. However, psychophysiological measures of persuasive processing (i.e., skin conductance response [SCR]) and objective driving measures of persuasive outcomes (i.e., in-vehicle Global Positioning System [GPS] devices) may provide further insights into the effectiveness of these advertisements. This study aimed to explore the persuasive processing and outcomes of 2 anti-speeding advertisements by incorporating both self-report and objective measures of speeding behavior. In addition, this study aimed to compare the findings derived from these different measurement approaches. Methods: Young drivers (N = 20, M age = 21.01 years) viewed either a positive or negative emotion–based anti-speeding television advertisement. While viewing the advertisement, SCR activity was measured to assess ad-evoked arousal responses. The RoadScout GPS device was then installed in participants' vehicles for 1 week to measure on-road speed-related driving behavior. Self-report measures assessed persuasive processing (emotional and arousal responses) and actual driving behavior. Results: There was general correspondence between the self-report measures of arousal and the SCR and between the self-report measure of actual driving behavior and the objective driving data (as assessed via the GPS devices). Conclusions: This study provides insights into how psychophysiological and GPS devices could be used as objective measures in conjunction with self-report measures to further understand the persuasive processes and outcomes of emotion-based anti-speeding advertisements.
Ferramenta da Terapia Gestalt: Trabalho com o Diálogo entre Partes Internas
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Gestalt
Trabalho com o Diálogo entre Partes Internas
Terapia Gestalt
Enciclopédia da Conscienciologia

description: Definologia: A Ferramenta da Terapia Gestalt denominada trabalho com o diálogo entre partes internas é uma técnica terapêutica que visa promover a integração e a harmonização dos diferentes aspectos da personalidade do indivíduo, através do reconhecimento e da comunicação entre as diferentes partes ou aspectos de si mesmo.
ИЧКИ ИШЛАР ОРГАНЛАРИ ПРОБАЦИЯ ХИЗМАТИНИНГ БОШҚА СОҲАВИЙ ХИЗМАТЛАР БИЛАН ҲАМКОРЛИГИ
Creators: name: Садуллоев, Ибрат
Publisher: name: Zenodo
Year: 2025

description: Ўзбекистон Республикасининг Конституцияси мамлакатимизда демократик ҳуқуқий давлатни барпо этишни эълон қилди. Демократик ҳуқуқий давлатни қуриш, қонунийлик ва ҳуқуқий-тартиботни амалга ошириш ва мустаҳкамлаш йўлида ҳуқуқни муҳофаза қилувчи органлар прокуратура, адлия, ички ишлар ва бошқа шу каби органлар фаолияти етакчи ўринни эгаллайди. Қонунийлик ҳуқуқий давлатда тўла амал қилади.
Pediatric Survivors of Retinoblastoma Are at Risk for Altered Bone Metabolism After Chemotherapy Treatment Early in Life
Creators: name: Schündeln, Michael M.
name: Hauffa, Pia K.
name: Bauer, Jens J.
name: Temming, Petra
name: Sauerwein, Wolfgang
name: Biewald, Eva
name: Bornfeld, Norbert
name: Hauffa, Berthold P.
name: Grasemann, Corinna
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Developmental Biology
Biological Sciences
Biotechnology
Cell Biology
Medicine

description: Survivors of childhood cancer frequently suffer from endocrine late effects, which are, at least partly, attributed to toxic effects of chemotherapy. Treatment of retinoblastoma typically involves chemotherapy at a very young age. The authors conducted a cross-sectional study to assess bone health in a pediatric cohort of 33 survivors of retinoblastoma (mean age: 4.4 years) who had undergone chemotherapy treatment at an especially young age (mean age: 0.76 years). Of these patients, 14 had unilateral and 19 bilateral retinoblastoma. Polychemotherapy consisted of treatment with cyclophosphamide, etoposide, vincristine, and carboplatin. Ten patients had undergone external beam radiotherapy. Clinical and biochemical parameters of growth, pubertal development, and bone health were obtained. A vitamin D deficiency was found in 51.7% of the patients, and 13.7% of patients displayed severe vitamin D deficiency. Secondary hyperparathyroidism and altered readings for bone formation or resorption markers were present in 15%. Nine percent reported bone pain or experienced fractures of the long bones after primary diagnosis. No difference between children with bilateral and unilateral disease or irradiated versus nonirradiated children was observed. The parameters of thyroid function, growth, and pubertal development were within age-appropriate norms in almost all children. In conclusion, altered parameters of bone health can be present in survivors of retinoblastoma at a young age and warrant regular follow-up in these children. The endocrine hypothalamic-pituitary axes, however, were not impaired at this early age in this group of survivors of retinoblastoma.
Prosody and lemma selection
Creators: name: Perry, Conrad
name: Zhuang, Jie
Publisher: name: Swinburne
Year: 2024

description: In three picture-naming experiments, we examined the effect of prosodic context on the synonyms people use to name pictures in Mandarin Chinese. This was done without time pressure. The results showed that when monosyllabic and Disyllabic synonyms (e.g., hen/chicken) were embedded in a context of pictures with either bisyllabic or trisyllabic names, participants gave bisyllabic responses to the synonyms more often than they did in a condition without such a context. The difference was very similar in magnitude in both the bisyllabic and trisyllabic contextual conditions. These results suggest that people are biased toward using synonyms that have numbers of syllables equal or similar to those of the prosodic context. If it is assumed that prosodic effects originate at a stage of processing beyond the lemma level, then this suggests either that multiple phonological forms of synonyms can be activated or that there is feedback from prosodic processing that influences lemma selection.
Building Adaptive Capacity in this series of Beyond-Surge-Capacity Outbreaks
Creators: name: Woods, David D.
Publisher: name: Zenodo
Year: 2020
Subjects: Resilience Engineering
Adaptive capacity
Beyond surge capacity
Covid-19
pandemic
Anticipation

description: Covers 10 points about how Medical Systems are reconfiguring under pressure at multiple levels simultaneously. Many Resilience Engineering findings and concepts are exemplified in medical systems adaptations to manage the beyond surge capacity Covid-19 outbreaks. The rolling series of Covid-19 outbreaks highlight the basic capabilities for resilient performance such as anticipation, building a readiness to respond, synchronizing/coordination over multiple roles and levels, and proactive learning to extend adaptive capacity. The Covid-19 outbreaks highlight how the risk of saturating response capabilities leads to a series of adaptations from deploy to mobilize to generate to keep pace with the increasing patient load and realted pressures.
Quantifying annual variations in field scale element flows and balances is essential for sustainable nutrient management in farming systems
Creators: name: Öborn, Ingrid
name: Bengtsson, Helena
name: Watson, Christine A.
name: Jonsson, Simon
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology

description: Element (nutrient) balances have proven useful in evaluating the sustainability of farming systems. However, most studies have been carried out over 1 year for single nutrients; thus data on annual variations are scarce, and so is the information on the behaviour of different elements. In addition, most studies have been carried out as farm-gate balances that do not include internal flows such as home-produced fodder and manure, which is crucial to assess the sustainability of management practices, in particular in organic systems. In this study, field level flows were monitored during 3 years and input–output mass balances were calculated for macronutrients (K, P) and trace elements (Cd, Zn) in adjacent organic and conventional dairy systems in Sweden. In addition, nitrogen balances were established for the first year of the study. Variations in element concentrations and mass flows between systems and years were analysed statistically for selected inputs and outputs. The K balances were negative (−39 to −22 kg ha−1 yr−1) all years in both systems, except one year in the conventional system, with less K harvested in organic crops. The organic P balance fluctuated around zero all years, whereas it was slightly positive in the conventional. Cadmium and Zn balances were positive in all years for both systems with lower surplus in the organic (Cd 0.24–0.70; Zn 225–463 g ha−1 yr−1). The inter-annual variation in flows was 10–40% for most elements. Incorporating variations, in addition to mean values, in field (soil surface) balances is recommended in order to assess and combat risks for long-term soil depletion or accumulation of essential and potential toxic elements.
Speed of lexical and nonlexical processing in French: The case of the regularity effect
Creators: name: Ziegler, Johannes C.
name: Perry, Conrad
name: Coltheart, Max
Publisher: name: Swinburne
Year: 2024

description: Words with irregular spelling-sound correspondences are read aloud more slowly than words with regular spelling-sound correspondences. This so-called regularity effect is modulated by word frequency, with low-frequency words showing larger costs than do high-frequency words. Because French has more regular spelling-to-sound correspondences than English, we expected a different pattern in French than in English. This was indeed the case, since regularity effects were obtained for both highand low-frequency words in French. We further showed that a French implementation of the dual-route cascaded model could not account for this pattern. In additional simulations, we investigated whether this failure was due to lexical processes being too fast (leaving little time for the nonlexical route to interfere) or nonlexical processes being too slow. The results showed that only speeding up the nonlexical route allowed the model to capture the data. This suggests that the delayed phonology assumption that characterizes nonlexical processing in the original model needs to be abandoned in a more regular orthography.
A phoneme-grapheme feedback consistency effect
Creators: name: Perry, Conrad
Publisher: name: Swinburne
Year: 2024

description: Recent studies examining the feedback consistency effect have been criticized for poor item selection (Peereman, Content, & Bonin, 1998). In the present study, an experiment was run with a new set of items, in which feedback consistency was manipulated at a phoneme-grapheme level. The results suggested that participants responded faster to feedback-consistent words than to feedback-inconsistent words. This was despite the feedback-consistent and feedback-inconsistent word groups' being matched on many other dimensions, including word frequency and subjective orthographic frequency. These results may differ from those of previous studies, since previous studies in English have measured feedback consistency at the rime-body level.
A dissociation between orthographic awareness and spelling production
Creators: name: Perry, Conrad
name: Ziegler, Johannes C.
name: Coltheart, Max
Publisher: name: Swinburne
Year: 2024

description: In this study, two nonword spelling and two orthographic awareness experiments were used to examine people's production and awareness of sound-spelling relationships. The results of the nonword spelling experiments suggest that, in general, people use phoneme-grapheme sized relationships when spelling nonwords. Alternatively, the results of the orthographic awareness experiments suggest that, under some circumstances, people can use larger sized sound-spelling relationships when judging how frequently subsyllabic relationships occur. Together the results suggest that there is a dissociation between sound-spelling production and sound-spelling awareness tasks, and the size of the sound-spelling relationships that people use varies under different tasks and task conditions.
Young drivers' responses to anti-speeding advertisements: Comparison of self-report and objective measures of persuasive processing and outcomes
Creators: name: Sherrie-Anne Kaye
name: Ioni Lewis
name: Algie, Jennifer
name: White, Melanie J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: Self-report measures are typically used to assess the effectiveness of road safety advertisements. However, psychophysiological measures of persuasive processing (i.e., skin conductance response [SCR]) and objective driving measures of persuasive outcomes (i.e., in-vehicle Global Positioning System [GPS] devices) may provide further insights into the effectiveness of these advertisements. This study aimed to explore the persuasive processing and outcomes of 2 anti-speeding advertisements by incorporating both self-report and objective measures of speeding behavior. In addition, this study aimed to compare the findings derived from these different measurement approaches. Methods: Young drivers (N = 20, M age = 21.01 years) viewed either a positive or negative emotion–based anti-speeding television advertisement. While viewing the advertisement, SCR activity was measured to assess ad-evoked arousal responses. The RoadScout GPS device was then installed in participants' vehicles for 1 week to measure on-road speed-related driving behavior. Self-report measures assessed persuasive processing (emotional and arousal responses) and actual driving behavior. Results: There was general correspondence between the self-report measures of arousal and the SCR and between the self-report measure of actual driving behavior and the objective driving data (as assessed via the GPS devices). Conclusions: This study provides insights into how psychophysiological and GPS devices could be used as objective measures in conjunction with self-report measures to further understand the persuasive processes and outcomes of emotion-based anti-speeding advertisements.
Are illness perception and coping style associated with the delay between symptom onset and the first general practitioner consultation in early rheumatoid arthritis management? An exploratory study within the CareRA trial
Creators: name: K Van Der Elst
name: D De Cock
name: E Vecoven
name: S Arat
name: S Meyfroidt
name: J Joly
name: P Moons
name: P Verschueren
name: R Westhovens
name: CareRA Study Group
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Objectives: Persons who are later diagnosed with early rheumatoid arthritis (ERA) often delay their first contact with a health professional after symptom onset. Besides initial symptoms, psychosocial characteristics of individuals may influence their help-seeking behaviour. We explored the role of disease characteristics, illness perception, and coping in patient-related delay before treatment initiation in recently diagnosed patients with ERA.Method: This exploratory, cross-sectional study included 112 patients with ERA from the Care for early RA (CareRA) trial for whom complete data on patient-related delay, coping, and illness perception were available. In addition to baseline sociodemographic and clinical data, the patients’ psychosocial profiles were assessed with the Utrecht Coping List (UCL) and the revised Illness Perception Questionnaire (IPQ-R). Correlations were measured by Spearman’s rho. Using regression analyses, we weighted the association of variables with patient-related delay.Results: Patient-related delay was positively correlated with perceptions of causality including psychological attributions (r = 0.301, p = 0.001), risk factors (r = 0.189, p = 0.045), immunity (r = 0.261, p = 0.005), and passive coping (r = 0.222, p = 0.018). It was negatively correlated with the 28 swollen joint count (SJC28; r = −0.194, p = 0.040), perceptions of treatment control (r = −0.271, p = 0.004), and illness coherence (r = −0.208, p = 0.028). Clinical and psychosocial variables explained 15% and 18%, respectively, of the variability in patient-related delay.Conclusions: Aside from a lower SJC, a longer patient-related delay was correlated with a passive coping style, a strong conviction of symptom causality, poor expected treatment control, and a feeling of limited illness coherence. Psychosocial aspects influence individuals’ help-seeking behaviour and are worth considering when aiming for a reduction in ERA treatment delay.
Linguistic difficulties in language and reading development constrain skilled adult reading
Creators: name: Perry, Conrad
name: Ziegler, J. C.
Publisher: name: Swinburne
Year: 2024

description: This study investigated whether the quality and specification of phonological representations in early language development would predict later skilled reading. Two perceptual identification experiments were performed with skilled readers. In Experiment 1, spelling difficulties in Grade 1 were used as a proxy measure for poorly specified representations in early language development. In Experiment 2, difficulties in perceiving and representing liquid and nasalized phonemes in final consonant clusters were used for the same purpose. Both experiments showed that words that were more likely to develop underspecified lexical representations in early language development remained more difficult in skilled reading. This finding suggests that early linguistic difficulties in speech perception and structuring of lexical representations may constrain the long-term organization and dynamics of the skilled adult reading system. The present data thus challenge the assumption that skilled reading can be fully understood without taking into account linguistic constraints acting upon the beginning reader.
Ferramenta da Terapia Familiar: Entrevista Familiar Inicial
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Familiar
Terapia Familiar
Entrevista Familiar Inicial
Enciclopédia da Conscienciologia

description: Definologia: A Entrevista Familiar Inicial é uma técnica utilizada na abordagem da Terapia Familiar para iniciar o processo terapêutico, compreender a dinâmica familiar e identificar as questões e preocupações dos membros da família.
title: Increasing the affinity of an O-Antigen polysaccharide binding site in Shigella flexneri bacteriophage Sf6 tailspike protein
Creators: name: Kunstmann, Ruth Sonja
name: Engström, Olof
name: Wehle, Marko
name: Widmalm, Göran
name: Santer, Mark
name: Barbirz, Stefanie
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften
subject: 570 Biowissenschaften; Biologie

description: Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted application. Bacteriophages contain a large repertoire of pathogen-binding proteins. These tailspike proteins (TSP) often bind surface glycans and represent a promising design platform for specific pathogen sensors. We analysed bacteriophage Sf6 TSP that recognizes the O-polysaccharide of dysentery-causing Shigella flexneri to develop variants with increased sensitivity for sensor applications. Ligand polyrhamnose backbone conformations were obtained from 2D H-1,H-1-trNOESY NMR utilizing methine-methine and methine-methyl correlations. They agreed well with conformations obtained from molecular dynamics (MD), validating the method for further predictions. In a set of mutants, MD predicted ligand flexibilities that were in good correlation with binding strength as confirmed on immobilized S. flexneri O-polysaccharide (PS) with surface plasmon resonance. In silico approaches combined with rapid screening on PS surfaces hence provide valuable strategies for TSP-based pathogen sensor design.
description: Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1417
Ethical pragmatism for innovative governance leadership The new role of humanistic health coaching
Creators: name: Patania, Stefano Luca
Publisher: name: Zenodo
Year: 2024

description: Recent debates on new leadership models proposed an ethical switch in healthcare. The Italian Health Coaching Association, after philological research, produced a new methodology to support the ethical leadership professional development by applying the prerogatives of objective humanistic ethics in a pragmatic way. Based on this model, the management development was implemented in a broader and more powerful way, inserting all the elements needed for an optimal Healthcare Learning Organization Governance, according with Maccoby Leadership standards. This preliminary health coaching experience seems to confirm many of the ethical-based hypothesis, producing performance improvement and beneficial contemporary effects on personal wellbeing.
Testing a computational account of category-specific deficits
Creators: name: Perry, Conrad
Publisher: name: Swinburne
Year: 2024

description: Patients displaying mild symptoms of Alzheimer's disease sometimes have more difficulty naming items from an artifact than from a natural kind category; others displaying more severe symptoms almost always have more difficulty naming items from a natural kind than from an artifact category. This paper examined a computational model of this double dissociation (Devlin, Gonnerman, Andersen, & Seidenberg, 1998). Four basic tests of the model were proposed: The model should be able to generalize to new exemplars, the model should be expandable such that training sets of a realistic size can be used, the model's performance should not be unduly affected by small changes in architecture, and the learning algorithm should produce results that are not inconsistent with any major underlying factor of semantic organization. The model was found to be deficient in all four areas. Results reported from the model may therefore have been idiosyncratic to the model and not reflect general properties of a real semantic system.
Elemental bio-imaging using laser ablation-triple quadrupole-ICP-MS
Creators: name: Bishop, David P.
name: Clases, David
name: Fryer, Fred
name: Williams, Elizabeth
name: Wilkins, Simon
name: Hare, Dominic J.
name: Cole, Nerida
name: Karst, Uwe
name: Doble, Philip A.
Publisher: name: Swinburne
Year: 2024

description: Elemental bio-imaging (EBI) of trace metal distributions in tissue sections is typically performed by laser ablation-single quadrupole-inductively coupled plasma-mass spectrometry (LA-ICP-SQ-MS) in which the sensitivity of biologically relevant elements such as Fe may be inhibited by polyatomic interferences. The triple quadrupole ICP-MS (ICP-QQQ-MS) is designed to reduce interferences and was examined for its potential application to EBI. Three tune modes; a no-gas, an H2, and an O2/H2 tune were developed and investigated for their suitability. All three performed well with high signal to noise ratios and low limits of detection. The O2/H2 tune was applied to a prostate cancer biopsy sample, with high levels of Zn found in the area correlating with the cancer. The oxygen mass shift was applied to image P and Se in a mouse brain. The unique focussing properties of the ICP-QQQ-MS and the ability to use mixed cell gases provided sensitive analyses of all measured isotopes with the O2/H2 tune, including those unaffected by mass shift reactions.
Sustainable lignin precursors for tailored porous carbon-based supercapacitor electrodes
Creators: name: Beaucamp, Anne
name: Muddasar, Muhammad
name: Crawford, Tara
name: COLLINS, MAURICE
name: Culebras, Mario
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 40
subject: Engineering

description: Sustainable materials are attracting a lot of attention since they will be critical in the creation of the next  generation of products and devices. In this study, hydrogels were effectively synthesized utilizing lignin, a non-valorised biopolymer from the paper industry. This study proposes a method based on utilizing lignin to create  highly swollen hydrogels using poly(ethylene) glycol diglycidyl ether (PEGDGE) as a crosslinking agent. The  influence of different crosslinker ratios on the structural and chemical properties of the resultant hydrogels was  investigated. Pore size was observed to be lowered when the amount of crosslinker was increased. The inclusion  of additional hydrophilic groups in the hydrogel network decreased the swelling capacity of the hydrogels as the  crosslinking density increases. These precursor materials were carbonised and electrochemically tested for  application as electrodes for supercapacitors with capacitance characterized as a function of crosslinker ratio.
Step Change Policy Brief - Off-grid Renewable Energy in Agriculture in Uganda
Creators: name: Action for Rural Women's Empowerment
name: Step Change
Publisher: name: Zenodo
Year: 2023
Subjects: Citizen Science
Renewable Energy
Agriculture
Uganda

description: Action for Rural Women's Empowerment (ARUWE) is one of the partners implementing the Science Transformation in Europe through Citizens involvement in Health, conservation and Energy Research (STEPCHANGE). The project focuses on establishing the evidence of, and bolster Off-grid Renewable Energy (RE) in agricultural production in rural Uganda, with particular focus on solar, charcoal briquettes and biogas renewable energy technologies. The main objective of the study is to provide evidence of the economic, environmental and societal potential of adopting off-grid renewable energy in agricultural production in rural Uganda. The study pursued four specific objectives, namely: a) Identify the impact achieved by ongoing projects in Kyankwanzi, Kiboga and Luwero districts where agricultural cooperatives have been trained and mobilized to use renewable energy technologies to promote agricultural productivity; b) Identify the impact achieved due to adoption of renewable energy technologies in agriculture production in other districts in Uganda; c) Provide evidence on the potential of up-scaling of the technology transfer experiences to the whole region and provides an estimate of the up-scaling potential at national level; and d) Analyze the current policy and institutional framework on the use of RE technologies in agricultural production in Uganda.
Based on the collected results, a policy brief was presented to the decision makers in a multi- stakeholders and fact-based dialogue conducted on the potential upscaling at regional and National levels of the process of technology transfer and adoption. Advised by the stakeholder, three separate policy briefs were prepared for systematic implementation advocacy and monitoring
Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS
Creators: name: Bishop, David P.
name: Hare, Dominic J.
name: Fryer, Fred
name: Taudte, Regina V.
name: Cardoso, Barbara R.
name: Cole, Nerida
name: Doble, Philip A.
Publisher: name: Swinburne
Year: 2024

description: Gadolinium (Gd)-based magnetic resonance imaging (MRI) contrasting agents interfere with the determination of selenium (Se) when analysed by single quadrupole inductively coupled plasma-mass spectrometry (ICP-MS). This paper demonstrates that an ICP-triple quadrupole-MS (ICP-QQQ-MS) with oxygen mass shift overcomes Gd++ interference on Se+ and mitigates typically encountered matrix and spectral based interferences. Normal human serum was diluted in a solution containing isopropanol, EDTA, NH4OH and Triton X-100. Samples were unspiked (control) serum; serum spiked with 0.127 μmol L-1 Se or 127 μmol L-1 Gd; and serum spiked with both 0.127 μmol L-1 Se and 127 μmol L-1 Gd. Consideration of collision/reaction gases and conditions for interference mitigation included helium (He); a 'low' and 'high' hydrogen (H2) flow, and oxygen (O2). The instrument tune for O2 was optimised for effective elimination of interferences via a mass shift reaction of Se+ to SeO+. The ICP-QQQ-MS was capable of detecting trace (>9.34 nmol L-1) levels of Se in serum in the presence of Gd in our simulated post-MRI serum sample. The multi-tune capabilities of the ICP-QQQ-MS may be adapted to eliminate other specific isobaric interferences that cause false positive results in other analyses where the analyte is confounded by doubly charged and/or polyatomic species.
Detection of gunshot residues using mass spectrometry
Creators: name: Taudte, Regina Verena
name: Beavis, Alison
name: Blanes, Lucas
name: Cole, Nerida
name: Doble, Philip
name: Roux, Claude
Publisher: name: Swinburne
Year: 2024

description: In recent years, forensic scientists have become increasingly interested in the detection and interpretation of organic gunshot residues (OGSR) due to the increasing use of lead- and heavy metal-free ammunition. This has also been prompted by the identification of gunshot residue- (GSR-) like particles in environmental and occupational samples. Various techniques have been investigated for their ability to detect OGSR. Mass spectrometry (MS) coupled to a chromatographic system is a powerful tool due to its high selectivity and sensitivity. Further, modern MS instruments can detect and identify a number of explosives and additives which may require different ionization techniques. Finally, MS has been applied to the analysis of both OGSR and inorganic gunshot residue (IGSR), although the "gold standard" for analysis is scanning electron microscopy with energy dispersive X-ray microscopy (SEM-EDX). This review presents an overview of the technical attributes of currently available MS and ionization techniques and their reported applications to GSR analysis.
Synthesis of Some Selectively N-Protected (1S,2S)-p-Nitrophenylserinol–Based Diamino-1,3-dioxanes and Tripodands
Creators: name: Nagy, Iulia
name: Moldovan, Oana
name: Popa, Flavia
name: Lameiras, Pedro
name: Morar, Cristina
name: Sacalis, Carmen
name: Darabantu, Mircea
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry

description: The unconventional methodology for the non-epimerisable cycloacetalization of optically active (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (p-nitrophenylserinol) (concd. H2SO4 96% as solvent and catalyst, i.e., sulphuric transacetalization) producing (2R,4S,5S) diamino-1,3-dioxanes, was enlarged by the use of N-protected forms of 2,2-DiMethoxyEthylAmine (DMEA, aminoacetaldehyde dimethylacetal). Conversely, N-protected derivatives of p-nitrophenylserinol were successfully cyclocondensed with DMEA in the same sulphuric conditions. N-functionalization of DMEA upon treatment with trimesic acid trichloride and cyanuric chloride yielded the corresponding triple amide and melamine respectively. Their adapted sulphuric transacetalization in triplicate in reaction with arylserinols (aryl: phenyl, p-nitrophenyl) afforded a new series of optically active tripodands.
Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents
Creators: name: López, Patricia
name: Iñiguez, Germán
name: Villarroel, Claudio
name: Merino, Paulina M.
name: Sir-Petermann, Teresa
name: Codner, Ethel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Biotechnology
subject: Cell Biology

description: We evaluated the association of hirsutism and oligomenorrhea (persistent menstrual cycles > 45 days) as screening criteria for the detection of biochemical hyperandrogenism (BH) and polycystic ovaries (PCOM) during adolescence and determined which androgens, granulosa cell hormone, ultrasonographic parameters have the best association with polycystic ovary syndrome (PCOS). Hirsute girls with oligomenorrhea (N = 26 Hirs/Oligo group) and non-hirsute girls with regular cycles (N = 63, C group) were studied. Prevalence of BH and PCOM, diagnostic performance of androgens and ultrasound parameters for PCOS diagnosis were analyzed. BH and PCOM prevalence were higher in the Hirs/Oligo girls than in the C girls (76.9% versus 25.5%; 92.3% versus 33.3%, respectively; p
Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia.
Creators: name: Hung, Christy
name: Patani, Rickie
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Stem Cells
subject: Stem Cells
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Cell Biology
subject: Cell Biology

description: FTD and ALS are two untreatable neurodegenerative diseases that exist on a clinical, genetic, and pathological spectrum. The VCP gene is highly relevant, being directly implicated in both FTD and ALS. Here, we investigate the effects of VCP mutations on the cellular homoeostasis of hiPSC-derived cortical neurons, focusing on endo-lysosomal biology and tau pathology. We find that VCP mutations cause abnormal accumulation of enlarged endo-lysosomes accompanied with impaired interaction between nuclear FUS and SFPQ in human cortical neurons. The spatial dissociation of intra-nuclear FUS and SFPQ correlates with alternative splicing of the MAPT pre-mRNA and increased tau phosphorylation. Importantly, we show that increased 4R tau using antisense oligonucleotide technology is sufficient to drive toxic changes in control human neurons, which phenocopy VCP-mutant neurons. In summary, our findings demonstrate that tau hyperphosphorylation, endolysosomal dysfunction, lysosomal membrane rupture, endoplasmic reticulum stress and apoptosis are driven by a pathogenic increase in 4R tau.
Post-challenge glycemia during pregnancy as a marker of future risk of type 2 diabetes: a prospective cohort study
Creators: name: Cederberg, Henna
name: Heinonen, Seppo
name: Hakkarainen, Heidi
name: Huopio, Hanna
name: Pääkkönen, Mirja
name: Voutilainen, Raimo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine

description: The aim of this study was to evaluate the glycemic measures from an oral glucose tolerance test (OGTT) during pregnancy as predictors of incident type 2 diabetes mellitus (T2DM). Patients diagnosed with gestational diabetes mellitus (GDM) were divided into two groups according to the results of OGTT: one abnormal value = GDM1 (n = 338) and two abnormal values = GDM2 (n = 151), while women with normal glucose tolerance served as controls (n = 385). Glucose tolerance was re-evaluated with an OGTT in a follow-up study (average follow-up time 7.3 ± 5.1 years). The incidence of T2DM after 10 years follow-up increased progressively by the degree of the glycemic abnormality during pregnancy: 0.8% in controls, 3.8% in GDM1 (adjusted HR 17.6, 95% CI 1.9–162.3) and 25.0% in GDM2 (adjusted HR 72.9, 95% CI 9.6–553.7), respectively (p = <0.0001). The risk of T2DM is significantly increased in women with two or more abnormal values in OGTT during pregnancy. Post-challenge glucose levels in OGTT were the best predictors of the incident T2DM in ROC analysis and they therefore identify the greatest risk group for targeted prevention of T2DM after GDM.
Methodology and Real-World Applications of Dynamic Uncertain Causality Graph for Clinical Diagnosis with Explainability and Invariance
Creators: name: Zhang, Zhan
name: Zhang, Qin
name: Jiao, Yang
name: Lu, Lin
name: Ma, Lin
name: Liu, Aihua
name: Liu, Xiao
name: Zhao, Juan
name: Xue, Yajun
name: Wei, Bing
name: Zhang, Mingxia
name: Gao, Ru
name: Zhao, Hong
name: Lu, Jie
name: Li, Fan
name: Zhang, Yang
name: Wang, Yiming
name: Zhang, Lei
name: Tian, Fengwei
name: Hu, Jie
name: Gou, Xin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Human-Computer Interaction (cs.HC)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: AI-aided clinical diagnosis is desired in medical care. Existing deep learning models lack explainability and mainly focus on image analysis. The recently developed Dynamic Uncertain Causality Graph (DUCG) approach is causality-driven, explainable, and invariant across different application scenarios, without problems of data collection, labeling, fitting, privacy, bias, generalization, high cost and high energy consumption. Through close collaboration between clinical experts and DUCG technicians, 46 DUCG models covering 54 chief complaints were constructed. Over 1,000 diseases can be diagnosed without triage. Before being applied in real-world, the 46 DUCG models were retrospectively verified by third-party hospitals. The verified diagnostic precisions were no less than 95%, in which the diagnostic precision for every disease including uncommon ones was no less than 80%. After verifications, the 46 DUCG models were applied in the real-world in China. Over one million real diagnosis cases have been performed, with only 17 incorrect diagnoses identified. Due to DUCG's transparency, the mistakes causing the incorrect diagnoses were found and corrected. The diagnostic abilities of the clinicians who applied DUCG frequently were improved significantly. Following the introduction to the earlier presented DUCG methodology, the recommendation algorithm for potential medical checks is presented and the key idea of DUCG is extracted.
Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood
Creators: name: R C Huang
name: E S Garratt
name: H Pan
name: Y Wu
name: E A Davis
name: S J Barton
name: G C Burdge
name: K M Godfrey
name: J D Holbrook
name: K A Lillycrop
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Cancer

description: Childhood obesity is a major public health issue. Here we investigated whether differential DNA methylation was associated with childhood obesity. We studied DNA methylation profiles in whole blood from 78 obese children (mean BMI Z-score: 2.6) and 71 age- and sex-matched controls (mean BMI Z-score: 0.1). DNA samples from obese and control groups were pooled and analyzed using the Infinium HumanMethylation450 BeadChip array. Comparison of the methylation profiles between obese and control subjects revealed 129 differentially methylated CpG (DMCpG) loci associated with 80 unique genes that had a greater than 10% difference in methylation (P-value < 0.05). The top pathways enriched among the DMCpGs included developmental processes, immune system regulation, regulation of cell signaling, and small GTPase-mediated signal transduction. The associations between the methylation of selected DMCpGs with childhood obesity were validated using sodium bisulfite pyrosequencing across loci within the FYN, PIWIL4, and TAOK3 genes in individual subjects. Three CpG loci within FYN were hypermethylated in obese individuals (all P < 0.01), while obesity was associated with lower methylation of CpG loci within PIWIL4 (P = 0.003) and TAOK3 (P = 0.001). After building logistic regression models, we determined that a 1% increase in methylation in TAOK3, multiplicatively decreased the odds of being obese by 0.91 (95% CI: 0.86 – 0.97), and an increase of 1% methylation in FYN CpG3, multiplicatively increased the odds of being obese by 1.03 (95% CI: 0.99 – 1.07). In conclusion, these findings provide evidence that childhood obesity is associated with specific DNA methylation changes in whole blood, which may have utility as biomarkers of obesity risk.
Sustainable supplier management – a review of models supporting sustainable supplier selection, monitoring and development
Creators: name: Zimmer, Konrad
name: Fröhling, Magnus
name: Schultmann, Frank
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: In the last two decades, pressure from various stakeholders has forced many companies to establish environmental and social improvements both in their company and their supply chains. The growing number of journal publications and conference proceedings confirms this change also in academia. The aim of this paper is to analyse and review scientific literature on sustainable supplier management (SSM) with a focus on formal models supporting decision-making in sustainable supplier selection, monitoring and development. For this purpose, a framework on SSM is proposed and a comprehensive content analysis including a criteria analysis is carried out. Beyond this, in total 143 peer-reviewed publications between 1997 and 2014 have been analysed to identify both established and overlooked research fields. Major findings are the rapidly growing interest of this topic in academia in recent years, the predominance of Analytic Hierarchy Process, Analytic Network Process and fuzzy-based approaches, the focus on the final evaluation and selection process step and the rare investigation of social and quantitative metrics. This review may be useful for practitioners and scientists as it outlines major characteristics in this field, which can serve as a basis for further research.
Sustainable supplier management – a review of models supporting sustainable supplier selection, monitoring and development
Creators: name: Zimmer, Konrad
name: Fröhling, Magnus
name: Schultmann, Frank
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: In the last two decades, pressure from various stakeholders has forced many companies to establish environmental and social improvements both in their company and their supply chains. The growing number of journal publications and conference proceedings confirms this change also in academia. The aim of this paper is to analyse and review scientific literature on sustainable supplier management (SSM) with a focus on formal models supporting decision-making in sustainable supplier selection, monitoring and development. For this purpose, a framework on SSM is proposed and a comprehensive content analysis including a criteria analysis is carried out. Beyond this, in total 143 peer-reviewed publications between 1997 and 2014 have been analysed to identify both established and overlooked research fields. Major findings are the rapidly growing interest of this topic in academia in recent years, the predominance of Analytic Hierarchy Process, Analytic Network Process and fuzzy-based approaches, the focus on the final evaluation and selection process step and the rare investigation of social and quantitative metrics. This review may be useful for practitioners and scientists as it outlines major characteristics in this field, which can serve as a basis for further research.