cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Oreonectes platycephalus Gnther
Creators: name: Du, Li-Na
name: Chen, Xiao-Yong
name: Yang, Jun-Xing
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Nemacheilidae
Oreonectes
Oreonectes platycephalus

description: Oreonectes platycephalus Gnther
Fig. 5
Oreonectes platycephalus Gnther, 1868, Catalog Fishes British Museum 7: 369 (small stream near top of Hongkong Moutains, China); Zheng, 1981, Freshwater Fishes of Guangxi: 162; Zheng, 1989, The Fishes of Pearl River: 46 (Jinxiu, Guangxi, China); Zhu, 1989, The Loaches of the Subfamily Nemacheilinae in China: 23 (Fuluo Mountain, Kwangtung, Jinxiu, Guangxi, China); Kottelat, 2001, Freshwater Fishes of Northern Vietnam: 46 (Quang Ninh Province, Vietnam).
Homaloptera rotundicauda Martens, 1868, Monatsb. Akad. Wiss. Berlin: 608 (Hong Kong, China)
Oreonectes yenlingi Lin, 1932, Lingnan Sci.J.Canton 11(3): 380 (White Cloud Mountain, Kwangtung, China)
Material examined: 25 ex. KIZ 200304597–600, 50.9–58.6 mm SL, 63.5–72.5 mm TL; KIZ 200304226, 49.2 mm SL, 60.7 mm TL; KIZ 200304009, 64.7 mm SL, 76.5 mm TL; KIZ 200304410–411, 59.8–67.8 mm SL, 75.3–83.6 mm TL; KIZ 200304434–440, 39.8–52.1 mm SL, 48.8–64.8 mm TL; KIZ 2003041136–1137, 66.7– 66.8 mm SL, 79.4–83.3 mm TL; KIZ 200510215034, 48.5 mm SL, 59.6 mm TL; KIZ 200510193741, 43.7 mm SL, 55.8 mm TL; KIZ 200510266401, 49.1 mm SL, 60.7 mm TL; KIZ 200510235472–5474, 57.4–70.6 mm SL, 69.3–86.8 mm TL; KIZ 20051016672–673, 54.4–60.6 mm SL, 66.9–73.8 mm TL, from Jinxiu County, Guangxi Zhuang Antonomous Region, China.
Diagnosis: Dorsum of head flat; eyes present; dorsal-fin origin posterior to pelvic-fin origin; dorsal-fin base and caudal-fin base with black pigment; caudal fin rounded; body covered with minute scales except for head; lateral line incomplete, with 16-18 pores; cephalic lateral-line system with 8 supraorbital, 3+10 infraorbital pores; sexual dimorphism, males have the genital papilla located immediately posterior to anus; gonad opens at end of fleshy prominence; vertebra 4+31~32 (3).
Distribution: Hong Kong, China; Fuluo Mountain and White Cloud Mountain, Kwangtung, China; Jinxiu County, Guangxi Zhuang Autonomous Region, China; Quang Ninh Province, Vietnam.
Remark: This species has a broad distribution, especially within Jinxiu County, Guangxi. For example, it can be found in Jinxiu River, Puquan River, Gufan River, Changdong River, Tongmu River, Jiajiang River and Guman River (Fig. 6).
description: Published as part of Du, Li-Na, Chen, Xiao-Yong & Yang, Jun-Xing, 2008, A review of the Nemacheilinae genus Oreonectes Günther with descriptions of two new species (Teleostei: Balitoridae), pp. 23-36 in Zootaxa 1729 on pages 29-30, DOI: 10.5281/zenodo.181269
Beyond dispute
Creators: name: Zuckerman, Emily Beth
Publisher: name: No Publisher Supplied
Year: 2008

description: In 1973 the federal government began investigating Sears, Roebuck & Co. for discrimination against women employees because, among other things, its commissioned sales force was predominantly male.  At trial, Sears argued that women were not interested in commissioned positions because they were too demanding.  The decision, which found Sears not liable for discrimination, sparked a great deal of debate among feminists and in the media over the expert witness testimony of two women's historians.  Employing oral histories, organizational records, court documents, and media accounts I use the case as a lens through which to view broader historical issues regarding women and work, social class, and national political changes during the 1970s and 1980s.  I give a detailed social history of the case, focusing on the players and events that affected the outcome, and a legal-political history of the time period as reflected through developments in the case.  This dissertation recovers cross-class organizing at the beginning of a case known only for its divisiveness.  It examines dynamics within second-wave feminism, including the implications of a shift in focus to the Equal Rights Amendment, the role of the equality/difference dilemma, and whether the loss in court to Sears was merely a defeat.  The company's corporate personality foreshadowed the lengths to which it would go to fight the EEOC.  I also reveal a significant amount of resistance within the first Reagan administration to changes in civil rights policy and show that the case continued with strong support despite ambivalence on the part of the government.  The long litigation process ensured a case that looked very different from its beginnings.  The feminist debate surrounding the trial highlights the end of a much longer story and distracts attention from critical issues.  I argue for de-centering this feminist dispute, and remembering the case instead for what it can tell us about debates over affirmative action, attempts by women activists alternatively to work within and challenge national policy, the limits of the law and second-wave feminism for improving the lives of working women, and the reasons why the workplace revolution for women stalled and remains so today.
Synthesis and evaluation of amphiphilic scorpion-like and star macromolecules for biomedical applications
Creators: name: Demirdirek, Bahar
Publisher: name: No Publisher Supplied
Year: 2009

description: Self-assembled and unimolecular amphiphilic macromolecules with pseudo-double branched and single tails were synthesized. Degradation behavior, drug loading efficiency, drug release rate and stability of macromolecules were investigated. The anti-tumor drug, Camptothecin and the anti-inflammatory drug, Indomethacin were used to evaluate drug loading and release efficiency. Unimolecular amphiphilic macromolecules were more stable in the presence of the enzyme, lipase and human serum albumin (HSA) compared to self-assembled macromolecules. Pseudo-branched macromolecules drug release rate was slower compared to linear macromolecules. Furthermore, self-assembled single tail amphiphilic macromolecule (AScMs) were modified to achieve active tumor targeting and to achieve high concentration of drug with cyclo(RGDfk) and Doxorubicin, respectively. Cyclo(RGDfk) conjugated AScMs showed higher uptake in tumor cells compared to AScMs alone. Furthermore, AScMs and Cyclo(RGDfk)-AScMs showed similar uptake profile with healthy cells. Higher loading efficiency was determined in Doxorubicin conjugated AScMs. On the other hand, lower IC50 value (high toxicity) was determined by AScMs-Dox conjugation.   Self-assembled pseudo branched macromolecules were modified with two carboxylate acids to achieve higher Low Density Lipoprotein (LDL) uptake. LDL uptake of branched macromolecules was compared with linear self-assembled macromolecules which are modified with carboxylic acid and sulfuric acid by our group members. Two carboxylate acid conjugated-AScMs (2CM branched) achieved the highest LDL uptake compared to other macromolecules.
Pharmacokinetics of chemopreventive compounds
Creators: name: Wu, Rachel Tsai-Han
Publisher: name: No Publisher Supplied
Year: 2008

description: Cancer claims millions of lives per year.  In an effort to find cures to cancer, scientists have turned to chemopreventive compounds that are ingested by humans on a daily basis.  Butylated hydroxyanisole (BHA) is a synthetic phenolic antioxidant that is commonly used as a food preservative.  Previous studies done on BHA have shown it to exhibit a wide range of biological activities that include protection against acute toxicity of chemicals, modulation of macromolecule synthesis and immune response, induction of phase II detoxifying enzymes, and its potential tumor-promoting activities.  Other studies have shown it to have chemopreventive effects.  However, little is known about the pharmacokinetics of BHA.  The first part of this thesis proposes a study to understand the pharmacokinetics of BHA better.  The data showed that BHA followed linear pharmacokinetics within the tested intravenous doses of 10 and 25 mg/kg.  The volume of distribution was found to be 1.8 L/kg with a plasma clearance of 60 mL/min/kg and a half-life of 0.7 hr. The bioavailability of BHA at oral doses of 25 mg/kg and 200 mg/kg was found to be 33% and 6%, respectively.  The second part of this thesis investigates the effect that Nuclear E2-factor related factor 2 (Nrf2) has on the pharmacokinetics of BHA.  Nrf2 belongs to the Cap'n'Collar family of basic region-leucine zipper transcription factors, has been shown to be an essential component of ARE-binding transcriptional machinery. Nrf2 is thought to facilitate the induction of many phase II detoxifying genes. The results of this study showed that Nrf2 deficient mouse had more extended and greater exposure to BHA when the compound is given orally than Nrf2 wild type mice.  This suggests that Nrf2 gene may be involved in the metabolism of BHA. The third part of this thesis investigates the usage of nanoparticle drug delivery systems. Previous pharmacokinetics studies done on chemopreventive compound, Dibenzoylmethane (DBM), which is a β-diketone structural analog of curcumin, is a minor constituent of licorice, yield unfavorable results.  The bioavailability of DBM when given orally was found to be only 7%.  This study was proposed in an effort to increase the bioavailability of DBM. The data showed promising results.  When DBM was administered orally to rats in a nanoparticle emulsion, all the pharmacokinetic parameter values increased significantly, compared to the pharmacokinetics parameter values yielded after oral administration of an equal dose in the previous delivery vehicle.  The bioavailability increased from 7% to 36% at an oral dose of 250 mg/kg.  Similar results were found in a test done on mice.
A Global Perspective on the Persistency and Mobility of Regulated Chemicals
Creators: name: Wolf, Raoul
name: Baskaran, Sivani
Publisher: name: Zenodo
Year: 2025

description: Slides that were presented at the ZeroPM webinar called

A Global Perspective on the Persistence and Mobility of Regulated Chemicals by Raoul Wolf and Sivani Baskaran from NGI. The webinar was held on the 4th of December 2024 and is found as a recording on the ZeroPM youtube channel
Prostate cancer chemoprevention by dietary phytochemicals
Creators: name: Barve, Avantika
Publisher: name: No Publisher Supplied
Year: 2009

description: Prostate cancer is one of the most frequent diagnosed forms of cancer among men in the United States. It displays considerable clinical, morphological and biological heterogeneity. Integrated information regarding candidate genes, transcription factors and pathways implicated in prostate cancer development is crucial to help stall prostate cancer. Currently the number of patients suffering from this invasive disease is on the rise and given the fact that when clinically significant this disorder is associated with a high mortality rate, prevention may prove to be the best approach. Chemoprevention entails the use of preferably dietary agents to block or suppress the various stages of prostate carcinogenesis. Flavonoids, the essential components of fruits and vegetables can modulate transcription factor AP-1 and its upstream signaling cascades mainly ERK-MAPK and JNK-MAPK in human androgen insensitive prostate cancer (PC3) cells. Soy isoflavone concentrate can upregulate the expression of several phase II detoxifying and antioxidant genes in an NF-E2-related factor 2 (Nrf2) dependent manner. In addition to detoxifying genes, soy isoflavone concentrate can also modulate the expression of genes such as LATS2, GREB1, calpain and many more in an Nrf2 dependent manner. The expression of most of these genes has been shown to be altered in prostate cancer progression. Animal models that can mimick key events in prostate cancer progression provide a valuable tool in the development of anti cancer therapies. In one such transgenic model, curcumin or PEITC suppressed high grade PIN levels. However a combination of low doses of these agents worked remarkably well in suppressing tumors all together. A deeper insight at the process of cancer development in the same model revealed that indeed prostate carcinogenesis occurs by progressive suppression of Nrf2 and its related phase II detoxifying and antioxidant enzymes. Treatment with γ-tocopherol enriched mixed tocopherol diet, on the other hand, significantly increased expression of Nrf2 as well as phase II detoxifying and antioxidant enzymes. Likewise a mixed tocotrienol diet suppressed tumor incidence by modulating cell cycle control and pro-apoptotic proteins. Finally, the observed chemopreventive effects of the dietary agents were correlated with their and their metabolites' circulating plasma levels.
Neocypridella Hartmann & Puri 1974
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Neocypridella

description: Neocypridella Hartmann & Puri, 1974
Nom. nov. pro Cypridella Vávra, 1895 nec Koninck, 1841
Neocypridella dartevellei (Brehm, 1939) Martens & Savatenalinton 2011: AT
Cyprinotus dartevellei Brehm, 1939
Neocypridella devexa (Daday, 1910) Martens 1984: AT
Cypridella devexa Daday, 1910
Neocypridella fossulata (Daday, 1910) Martens 1984: AT
Cypridella fossulata Daday, 1910 (sensu Martens 1984)
Syn.: Cypretta reticulata Lowndes, 1932 (fide Martens 1984)
Syn.: Cyprinotus lowndesi Gauthier, 1939 (fide Martens 1984)
Syn.: Eucypris tumida Klie, 1939 (fide Martens 1984)
Syn.: Eucypris brevis Rome, 1962 (fide Martens 1984)
Syn.: Eucypris palustris Rome, 1962 (fide Martens 1984)
* Neocypridella lemurensis (Vávra, 1895) Martens 1984: AT
Cypridella lemurensis Vávra, 1895
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on pages 82-83, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Molecular regulation of insulin-like growth factor binding protein-5 by signaling molecules downstream of the IGF-I receptor in mammary epithelial cells
Creators: name: Brandimarto, Jeffrey Alan
Publisher: name: No Publisher Supplied
Year: 2009

description: The insulin-like growth factor binding proteins (IGFBP) are important regulators of mammary epithelial cell (MEC) growth and can either enhance or inhibit IGF-I action.   IGF-I activates the IGF-I receptor (IGF-IR) to initiate two well-characterized signaling pathways; the phosphoinositide 3-kinase pathway (PI3K) and the mitogen activated protein kinase (MAPK) pathway.  In the bovine MEC line MAC-T, the PI3K pathway is required for both basal and IGF-I stimulated IGFBP-5 expression.  In contrast, inhibition of the MAPK pathway with the chemical inhibitor PD98059 leads to an increase in IGFBP-5 expression in both basal and IGF-I treated conditions.  In the present study, we identified molecules downstream of the IGF-IR that might play a role in the inhibitory regulation of IGFBP-5 expression via the MAPK pathway.The MAPK pathway terminates with the activation of ERK1/2.  Activated ERK1/2 enters the nucleus where it affects numerous transcriptional factors.  ERK1/2 has been shown to inhibit activation of the peroxisome proliferator-activated receptor gamma (PPARγ).  Inhibition of PPARγ with the chemical inhibitor GW9662 led to a decrease in IGFBP-5 message in PD98059-treated MAC-T.  Activation of PPARγ and PPARβ/δ via the agonists Rosiglitazone and GW0742, respectively, was found to increase basal IGFBP-5 mRNA expression in murine MEC but not in MAC-T cells.While PPARγ contributed to the PD98059-stimulated increase in IGFBP-5 message, it was unable to account for the total increase.  We therefore examined the promoter region of IGFBP-5 to identify factors that could be affected by mitogens.  Both mouse and human IGFBP-5 promoters contain a consensus NFκB binding site.  In the present study, phenethyl caffeiate, an inhibitor of NFκB, almost completely inhibited the increase in IGFBP-5 observed with PD98059 and IGF-I + PD98059-stimulated IGFBP-5 mRNA and protein expression in MAC-T cells.  Interestingly, IGFBP-3 expression was inversely regulated by phenethyl caffeiate.In conclusion the synergistic increase in IGFBP-5 expression observed with IGF-I and inhibition of the MAPK pathway may be due to the formation of a PPARγ NFκB complex that binds to the promoter region of IGFBP-5.  Rapid ERK dephosphorylation has been reported in involution, therefore this regulation may be important in inducing IGFBP-5 during involution in the bovine mammary gland.
Diversity of chemosynthetic thiosulfate oxidizing bacteria from diffuse flow hydrothermal vents and their role in mercury detoxification
Creators: name: Crespo-Medina, Melitza
Publisher: name: No Publisher Supplied
Year: 2009

description: The mixing of hydrothermal fluids with seawater creates chemical, temperature, and pH gradients that support chemosynthetic primary production at deep-sea vents. These fluids are enriched with reduced sulfur compounds and their oxidation under aerobic conditions is considered the main chemosynthetic process at the vents. The main objective of my research was to gain a better understanding of the aerobic chemosynthetic thiosulfate oxidation processes at deep-sea hydrothermal vents, by studying the abundance and diversity of chemosynthetic thiosulfate oxidizing bacteria, and their role on the detoxification of heavy metals, with an emphasis on mercury detoxification. Fluids, sediments, and biomass from microbial colonization experiments were collected during several expeditions to the East Pacific Rise (EPR) at “9º50’N, 104º17’W”  and to the Guaymas Basin, Gulf of California. Microbial isolations were carried out from diluted and undiluted samples. Isolates were identified by 16S rRNA gene analysis. The isolates obtained in pure cultures were related to the genera Thiomicrospira, Halothiobacillus, Hydrogenovibrio, Thioclava, Thalassospira, and Pelagibaca, as well as a new isolate EPR 70, which was described as a new species, Salinisphaera hydrothermalis. The isolates were further characterized, and their functional genes encoding enzymes for carbon fixation (RubisCO) and thiosulfate oxidation (SoxB) were analyzed. The Most Probable Number (MPN) technique was carried out in order to determine the abundance of chemosynthetic thiosulfate oxidizing bacteria, and the values obtained were compared with the total number of microorganisms per sample, estimated from microscopic direct counts. Our data show that this group of microorganisms represented from 103 to 107 cells per ml of sample, which accounts for about 0.002% to 14.1% of the total cell counts per sample. The chemical composition of the fluids was analyzed, and results indicated that hydrothermal fluids were enriched in mercury with concentrations comparable to the concentrations found in contaminated surface waters. MPN counts were done with the addition of mercury in order to determine the percentage of chemosynthetic thiosulfate oxidizing bacteria that were mercury resistant. Results indicated that from 0.2 to 24.6% of the chemosynthetic bacteria were resistant, suggesting an adaptation to life in the presence of this toxic metal.
Neocypridopsis Klie 1940
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Neocypridopsis

description: Neocypridopsis Klie, 1940
Syn.: Cypridopsis (Candonella) (Claus, 1891) Vávra 1897 (partim) (fide G.W. Müller 1912)
Syn.: Notiocypridopsis De Deckker, 1981 (fide Martens & Behen 1994)
Neocypridopsis albida (Sars, 1901) Karanovic & Datry 2009: NT
Paracypridopsis albida Sars, 1901
Neocypridopsis costata (Daday, 1910) Klie 1940: AT
Oncocypris costata Daday, 1910
Syn.: Zonocypris dadayi Lowndes, 1932 nom. nov. pro Z. costata (Daday, 1910) nec Z. costata (Vávra, 1897) G.W. Müller, 1898
* Neocypridopsis debilis Klie, 1940: NT
Neocypridopsis frigogena (Graf, 1931) Martens & Behen 1994: ANT, NT
Cypridopsis frigogena Graf, 1931
Neocypridopsis granulosa (Daday, 1902) Martens & Behen 1994: NA, NT
Potamocypris granulosa Daday, 1902
Neocypridopsis inaudita (Furtos, 1936) Klie 1940: NT
Cypridopsis inaudita Furtos, 1936
Neocypridopsis mexicana (Furtos, 1938) Danielopol 1986: NT
Cypridopsis mexicana Furtos, 1938
Neocypridopsis montevidea (Vávra, 1898) Martens & Behen 1994: NT
Cypridopsis (Candonella) montevidea Vávra, 1898
Neocypridopsis nana (Sars, 1901) Klie 1940: NT
Cypridopsella nana Sars, 1901
Neocypridopsis paradisea (Vávra, 1898) Martens & Behen 1994: NT
Candonella paradisea Vávra, 1898
Neocypridopsis yucatanensis (Furtos, 1936) Klie 1940: NT
Cypridopsis yucatanensis Furtos, 1936
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 83, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Additional file 2: of Reliability, validity and responsiveness of the German self-reported foot and ankle score (SEFAS) in patients with foot or ankle surgery
Creators: name: Dariusch Arbab
name: Kuhlmann, Katharina
name: Schnurr, Christoph
name: Bouillon, Bertil
name: LĂźring, Christian
name: KĂśnig, Dietmar
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: English SEFAS Questionnaire. (PDF 32Â kb)
Physically interpretable machine learning methods for transcription factor binding site identification using principled energy thresholds and occupancy
Creators: name: Drawid, Amar Mohan
Publisher: name: No Publisher Supplied
Year: 2009

description: Regulation of gene expression is pivotal to cell behavior. It is achieved predominantly by transcription factor proteins binding to specific DNA sequences (sites) in gene promoters. Identification of these short, degenerate sites is therefore an important problem in biology. The major drawbacks of the probabilistic machine learning methods in vogue are the use of arbitrary thresholds and the lack of biophysical interpretations of statistical quantities. We have developed two machine learning methods and linked them to the biophysics of transcription factor binding by incorporating simple physical interactions. These methods estimate site binding energy, recognizing that it determines a site's function and evolutionary fitness. They use the occupancy probability of a transcription factor on a DNA sequence as the discriminant function because it has a straightforward physical interpretation, forms a bridge between binding energy and evolutionary fitness, and has a natural threshold for classifying sequences into sites that allows establishing the threshold in a principled manner. Our methods incorporate additional characteristics of sites to enhance their identification. The first method, based on a hidden Markov model (HMM), identifies self-overlapping sites by combining the effects of their alternative binding modes. It learns the threshold by training emission probabilities using unaligned sequences containing known sites and estimating transition probabilities to reflect site density in all promoters in a genome. While identifying sites, it adjusts parameters to model site density changing with the distance from the transcription start site. Moreover, it provides guidance for designing padding sequences in experiments involving self-overlapping sites. Our second method, the Phylogeny-based Quadratic Programming Method of Energy Matrix Estimation (PhyloQPMEME), integrates evolutionary conservation to reduce false positives while identifying sites. It learns the threshold by solving an iterative quadratic programming problem to optimize the distribution of correlated binding energies of neutrally evolving orthologous sequences while restricting the values of binding energies of known sites and their orthologs. We have used the NF-κB transcription factor family as a case study for both methods and gained new insights into its biology.
Improving interactive multisensory simulation and rendering through focus on perceptual processes
Creators: name: Edmunds, Timothy
Publisher: name: No Publisher Supplied
Year: 2009

description: In this dissertation we present a novel approach to the design of multisensory interactive applications.  We develop methods that improve the effectiveness of this type of application by incorporating the existing understanding of the human perceptual system. We quantitatively demonstrate the validity of our techniques through user studies and laboratory measurement.Explicitly including the human user as a part of the model for interactive application design, we propose a design approach for training simulators that augments the dynamical simulation of an interactive task (e.g., a surgical procedure) with feedback that highlights the aspects of the interaction that are perceptually pertinent for the purposes of training. We show how this type of augmentation can improve the training effectiveness of a simulator without necessitating more expensive rendering hardware. To make our perceptually-based augmentation technique more useable by application designers, we propose a decomposition approach to simplify the general process of developing the appropriate augmentation for a training simulator. We validated our approach by applying it to the design of a training simulator for a haptic search task; we conducted a user study that found a statistically significant improvement in the training effectiveness of the augmented simulator vs. an unaugmented simulator. We propose specific guide-lines for how existing psychophysical experimental results can be used to build augmentations for training simulators. We also developed a novel rendering architecture for distributed interactive applications that is suitable for the type of perceptually augmented simulator described above. Our architecture uses prediction of perceptually pertinent interaction events to achieve application latency and asynchrony bounds that can be constrained to within psychophysically established thresholds.
Dietary lutein modulates expression of prostate cancer biomarker genes in human prostate cancer cell line
Creators: name: Gokarn, Sarita V.
Publisher: name: No Publisher Supplied
Year: 2009

description: Prostate cancer is the second leading cause of death from malignancies in men and is the most commonly diagnosed cancer in the United States. Epidemiological studies have shown the inverse relationship between consumption of various carotenoids and the risk of prostate cancer. Lutein is a fat-soluble, oxycarotenoid present in human serum and is also present in the liver, colon, lung and prostate tissues. Lutein is not synthesized by the human body and is primarily consumed from dark-green leafy vegetables such as kale and spinach, as well as from egg yolks, avocado, corn and fruits like orange and kiwi. Lutein has gained popularity through its role in preventing age-related macular degeneration (AMD). Anti-inflammatory activity of lutein has also been the focus of a number of in vitro and in vivo studies. Recently much attention has focused on the role of lutein against various cancers including prostate cancer, however no mechanism of action was determined.  Our objective is to determine whether lutein modulates prostate cancer biomarker genes in hormone refractory prostate cancer (PC-3) cell lines using Oligo GEArray® DNA Microarray, which contains 263 genes involved in the progression and diagnosis of prostate cancer. PC-3 cells were treated with 10 μM non-toxic concentrations of lutein as determined by MTT cell viability assay. Isolated RNA was reverse-transcribed to cDNA, transcribed to cRNA and hybridized with microarrays. Microarray results demonstrated the down-regulation of epidermal growth factor receptor (EGFR), insulin-like growth factor 1 receptor (IGF1R), breast cancer gene 1 (BRCA1), cyclin dependant kinase 5 (CDK5), kallikrein 14 (KLK14) and prostate cancer antigen 3 (PCA3). Microarray results also showed the up-regulation of ras association domain family member 1 (RASSF1) and glutathione S-transferase pi 1 (GSTP1). Modulated genes were validated by Real-Time PCR and demonstrated down-regulation of IGF1R, EGFR, BRCA1, CDK5, KLK14 and PCA3 by 83%, 60%, 50%, 44%, 41% and 40% respectively. Similarly, up-regulated genes were also validated by Real-Time PCR and results showed GSTP1 and RASSF1 up-regulated by 82% and 70%. Modulated genes were further analyzed at the translational level using Western Blot. Among all the prostate cancer biomarker genes, IGF1R, EGFR and GSTP1 were most significantly modulated in Real-Time PCR analysis. Western blot analysis demonstrated that lutein treatment down-regulated the protein expression of IGF1R and EGFR by 40.4% and 33.1% while up-regulating GSTP1 by 30.0%. These results demonstrate the potential of lutein to modulate a number of key biomarker genes involved in human prostate cancer proliferation, differentiation, angiogenesis and apoptosis.
Shepherding in greener pastures
Creators: name: Fichter, Stephen Joseph
Publisher: name: No Publisher Supplied
Year: 2009

description: Since the late 1960s, roughly one-quarter of Roman Catholic priests in America have resigned, motivated mainly by a desire to marry. While several sociologists (e.g., Fichter, Greeley, Hoge, and Schoenherr) have studied the motivations and actions of resigned priests (who usually maintain their Catholic identity and take up some form of non-pastoral employment after their transition), this research seeks to describe a never-before-studied subgroup that chose to re-focus their lives towards Protestant ministry. The research offices of the five mainline Protestant Churches (Congregational, Episcopal, Lutheran, Methodist, Presbyterian) identified 414 such ministers, of whom 32 percent chose to participate. All 133 respondents completed a 12-page survey either by anonymous return mail or during a telephone or a face-to-face interview.The analysis plan, designed to answer the four research questions (outlined below), consisted of three parts: 1) a detailed reporting on the frequencies of the principal variables, 2) a series of cross-tabulations, and 3) several multivariate regression models.The first major finding confirmed that marriage was their main motivator. The distinction between those who followed their "heart" as opposed to those who followed their "head," highlighted the fact that both emotion and intellect had a role to play. Although one could get the impression (by listening to their retrospective narratives only) that both head and heart had equal "pull," analyzing their concrete actions revealed that most followed their hearts first by marrying before switching affiliation. Results from the second research question revealed a definite period effect that can be traced back to the conclusion of the Second Vatican Council.The third line of inquiry verified the link between parental support for the transition and current levels of satisfaction, with the added nuance that such a correlation is stronger among former diocesan priests than it is among religious priests. Finally, results from the fourth research question support the hypothesis that the obligations of marriage limit the number of hours that a minister can dedicate to his flock. These "greener pastures shepherds" follow a work schedule that is more similar to their current denomination's average than it is to the Catholic priest model.
INTERSECTING WORLD: RELIGION, POLITICS AND IDENTITY IN ORHAN PAMUK'S 'SNOW'
Creators: name: V. Marimuthu* & Dr. P. Ananthan**
Publisher: name: Zenodo
Year: 2024

description: In "Snow," Orhan Pamuk intricately weaves a narrative that explores the intersections of religion, politics and identity within a contemporary Turkish setting. The novel is set in the isolated town of Kars and follows the protagonist, Ka, a poet and political exile, as he navigates a landscape fraught with ideological conflict. Pamuk delves into the tensions between secularism and Islamism, the personal and collective struggles for identity, and the impact of political turbulence on individual lives. Through richly drawn characters and a suspenseful plot, "Snow" offers a profound commentary on the complexities of modern Turkey, reflecting broader global themes of cultural and political polarization. The novel ultimately raises questions about faith, freedom and the quest for meaning in a divided world.
Producing a 'space of dignity'
Creators: name: Villegas-Delgado, Claudia
Publisher: name: No Publisher Supplied
Year: 2008

description: I explore the production of new political, cultural and economic spaces (including the Zapatista Rebel Territory, Rebel Autonomous Municipalities, Caracoles and Juntas) constructed by the Zapatista National Liberation Army (EZLN), an indigenous rebellion in the Mexican state of Chiapas that rose up against the government on January 1, 1994. These spaces are articulated as a symbol of and material basis for sustaining the long-term resistance begun by the EZLN to demand a 'space of dignity' for the indigenous peoples. Based on the major stages in the EZLN's political practice from 1994 to 2003 --the Declarations of the Lacandona Jungle, the declaration of the Zapatista Rebel Territory, and current phase of Good Government--I discuss further how a 'space of dignity' can be conceptually defined, how it can be socially produced, and how it can be a means for social transformation.My approach to the Zapatista struggle sheds a light not only on the resulting relationships between space, dignity and resistance, but it looks forward to the meaning these concepts and relationships have for understanding the nature of the Zapatista rebellion and the contribution of this experience within the larger context of the production of space in capitalism.I conclude that the notion of a 'space of dignity' can provide an abstract framework to reflect on the possibilities for thinking of space as a means for revolutionary transformation, namely for organized resistance against neoliberal globalization. And that for the Zapatista rebellion, the practical meaning of this ultimate goal has resulted in the re-signification of the notion of dignity--both as a cultural and geographical framework--from which to think and construct spaces for defending autonomy and territory for the indigenous peoples of Mexico.This research is focused around a case study using qualitative research methodologies, combining ethnographic and archival sources with extensive fieldwork, conducted in 2002 and 2004 in the EZLN rebel territories.
Carrageenan effect on the water retention and texture in processes turkey breast
Creators: name: Lamarco-Fisher, Gail
Publisher: name: No Publisher Supplied
Year: 2009

description: A wide range of comminuted meat products are produced in the food industry for deli meats and sandwich products.  A major problem in processing these meats, particularly low fat poultry products, is the loss of water (syneresis) and toughening of texture during cooking, accompanied by crumbling during slicing.  To overcome these problems, carrageenan is often added to meats to bind water and entrap muscle tissue particles, providing a more cohesive product.  Up to 1.5% carrageenan is permitted by law and early applications typically used these levels.  However, high levels of carrageenan contribute distinctive off-flavors, textures uncharacteristic of meat, and decreased freeze-thaw stability. Consequently, the lowest levels feasible to maintain meat qualities should be used.This study investigated stabilizing effects of low carrageenan levels (0.2, 0.4, and 0.6%) in processed turkey breast formulated with moisture: protein ratios of 4:1, 5:1, and 6:1.  Ground turkey breast was tumbled with brine, packaged in bags, baked at 180° F, and cooled.  Traditional meat properties of cook yield, refrigerator purge, freeze thaw stability, and textural characteristics were measured. Hydration and swelling vs. full solubilization and gelation of carrageenan were visualized microscopically.At the lowest moisture level, protein and component salts controlled water binding; carrageenan added no extra stability and had little effect on cohesiveness or other textural attributes.  In turkey breast formulations with higher moisture, carrageenan increased cook yields. Microscopy revealed hydrated, swollen, and intact carrageenan granules, as well as release and gelation of carrageenan polymers.  A mechanism to explain carrageenan action in meats was proposed.  In low water systems, muscle proteins control water binding and carrageenan has no influence on product qualities.  As added water increases, carrageenan binds excess water not bound by the proteins, and particles begin to swell, contributing to water retention and firmness in meat products.  At the highest water levels, carrageenan binds sufficient water to burst some particles and release carrageenan polymers, which then gel in regions surrounding proteins. Some hydrated, swollen particles also remain intact and contribute to solidity.  Carrageenan gelation contributes to softening of textures and freeze thaw stabilization in high moisture systems.
Neolimnocythere Delachaux 1928
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Limnocytheridae
Neolimnocythere

description: Neolimnocythere Delachaux, 1928
Neolimnocythere erinacea Delachaux, 1928: NT
* Neolimnocythere hexaceros Delachaux, 1928: NT
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 83, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
A defense of Cartesian certainty
Creators: name: Wykstra, Stephanie Larsen
Publisher: name: No Publisher Supplied
Year: 2008

description: This dissertation examines Rene Descartes' view of certainty and defends the view that Cartesian certainty is possible. The first half of the dissertation includes an interpretation of Descartes'  epistemology as well as an examination of other interpreters' readings. The second half of the dissertation is a defense of the claim that Cartesian certainty of a particular kind is possible; it includes a variety of contemporary objections and replies in defense of the possibility of certainty.
MOESM1 of Longitudinal study of influenza A virus circulation in a nursery swine barn
Creators: name: Ferreira, Juliana
name: Grgić, Helena
name: Friendship, Robert
name: Wideman, Greg
name: Nagy, Éva
name: Poljak, Zvonimir
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1. Spearman correlation coefficients with statistical significance adjusted for multiple comparisons using Šidák approach.
title: Living the Vision: A Seminar in Art Education for Research and Curriculum Development, 1965 to 2016
Creators: name: Diket, Read
Publisher: name: The Pennsylvania State University Libraries
Year: 2019

description: Published in Transdisciplinary Inquiry, Practice, and Possibilities in Art Education: Proceedings from The Penn State Seminar @50; https://doi.org/10.26209/arted50
Neostrandesia Ferreira 2019
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Neostrandesia

description: Neostrandesia Ferreira et al., 2019
* Neostrandesia striata Ferreira et al., 2019: NT
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 83, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Neozonocypris Klie 1944
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Notodromadidae
Neozonocypris

description: Neozonocypris Klie, 1944
* Neozonocypris congensis Klie, 1944: AT
Neozonocypris globosa Rome, 1962: AT
Neozonocypris mirabilis Rome, 1962: AT
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 83, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Newnhamia King 1855
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Notodromadidae
Newnhamia

description: Newnhamia King, 1855
Newnhamia dumonti George & Martens, 2003: OL
* Newnhamia fenestrata King, 1855: AU, OL
Syn.: Newnhamia gulielmi King, 1855 (fide De Deckker 1979a)
Newnhamia fuscata (Brady, 1886) G.W. Müller 1912: AU
Notodromas fuscata Brady, 1886
Newnhamia insolita De Deckker, 1979: AU
Newnhamia patagonica (Vávra, 1898) Vávra 1901: NT
Notodromas patagonica Vávra, 1898
Newnhamia petiola De Deckker, 1979: AU
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 84, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Additional file 6: Figures S1â  S7. of The nuclear receptor ERÎ˛ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading
Creators: name: Tarallo, Roberta
name: Giurato, Giorgio
name: Bruno, Giuseppina
name: Ravo, Maria
name: Rizzo, Francesca
name: Salvati, Annamaria
name: Ricciardi, Luca
name: Marchese, Giovanna
name: Cordella, Angela
name: Rocco, Teresa
name: Gigantino, Valerio
name: Biancamaria Pierri
name: Cimmino, Giovanni
name: Milanesi, Luciano
name: Ambrosino, Concetta
name: Nyman, Tuula
name: Nassa, Giovanni
name: Weisz, Alessandro
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary figures with legends. (DOCX 3897 kb)
Additional file 1: Table S1. of Lifestyle, gene gain and loss, and transcriptional remodeling cause divergence in the transcriptomes of Phytophthora infestans and Pythium ultimum during potato tuber colonization
Creators: name: Ah-Fong, Audrey
name: Shrivastava, Jolly
name: Judelson, Howard
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: RNA-seq statistics. (PDF 39Â kb)
Ngarawa De Deckker 1979
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Cyprididae
Ngarawa

description: Ngarawa De Deckker, 1979
* Ngarawa dirga De Deckker, 1979: AU
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 84, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Additional file 1: of Current practice in methodology and reporting of the sample size calculation in randomised trials of hip and knee osteoarthritis: a protocol for a systematic review
Creators: name: Copsey, Bethan
name: Dutton, Susan
name: Fitzpatrick, Ray
name: Lamb, Sarah
name: Cook, Jonathan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Computational Biology

description: This includes the PRISMA Checklist. The line numbers relate to the original manuscript submission. (DOCX 29 kb)
Notacandona Karanovic & Marmonier 2003
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Candonidae
Notacandona

description: Notacandona Karanovic & Marmonier, 2003
Notacandona boultoni Karanovic & Marmonier, 2003: AU
Notacandona gratia (Karanovic, 2005) Karanovic 2007: AU
Origocandona gratia Karanovic, 2005
* Notacandona modesta Karanovic & Marmonier, 2003: AU
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 84, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383
Additional file 2: of Current practice in methodology and reporting of the sample size calculation in randomised trials of hip and knee osteoarthritis: a protocol for a systematic review
Creators: name: Copsey, Bethan
name: Dutton, Susan
name: Fitzpatrick, Ray
name: Lamb, Sarah
name: Cook, Jonathan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This details the search terms used for the MEDLine database. (DOCX 13 kb)
MOESM5 of Increased lipid production by heterologous expression of AtWRI1 transcription factor in Nannochloropsis salina
Creators: name: Kang, Nam
name: Kim, Eun
name: Kim, Young
name: Bongsoo Lee
name: Won-Joong Jeong
name: Byeong-Ryool Jeong
name: Chang, Yong
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Computational Biology

description: Additional file 5: Table S3. Specific growth rate and biomass yield of WT and NsAtWRI1 transformants.
Notocythere Hart & Hart 1967
Creators: name: Meisch, Claude
name: Smith, Robin J.
name: Martens, Koen
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Ostracoda
Podocopida
Entocytheridae
Notocythere

description: Notocythere Hart & Hart, 1967
Notocythere antichthon Hart & Hart, 1967: AU
Notocythere blundelli Hart & Hart, 1967: AU
Notocythere erica Hart & Hart, 1967: AU
Notocythere grampians Hart & Hart, 1967: AU
Notocythere mirranatwa Hart & Hart, 1967: AU
Notocythere rieki Hart & Hart, 1967: AU
Notocythere synomodites Hart & Hart, 1967: AU
* Notocythere syssitos Hart & Hart, 1967: AU
Notocythere tasmanica Hart & Hart, 1967: AU
description: Published as part of Meisch, Claude, Smith, Robin J. & Martens, Koen, 2024, An updated subjective global checklist of the extant non-marine Ostracoda (Crustacea), pp. 1-144 in European Journal of Taxonomy 974 on page 84, DOI: 10.5852/ejt.2024.974.2767, http://zenodo.org/record/14500383