cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function
Creators: name: Schultz, D. E.
name: Yi, M.
name: Lemon, S. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a cellular enzyme involved in glycolysis, binds specifically to several viral RNAs, but the functional significance of this interaction is uncertain. Both GAPDH and polypyrimidine tract binding protein (PTB) bind to overlapping sites in stem-loop IIIa of the internal ribosome entry site (IRES) of Hepatitis A virus (HAV), a picornavirus. Since the binding of GAPDH destabilizes the RNA secondary structure, we reasoned that GAPDH may suppress the ability of the IRES to direct cap-independent translation, making its effects antagonistic to the translation-enhancing activity of PTB (D. E. Schultz, C. C. Hardin, and S. M. Lemon, J. Biol. Chem. 271:14134–14142, 1996). To test this hypothesis, we constructed plasmids containing a dicistronic transcriptional unit in which the HAV IRES was placed between an upstream GAPDH-coding sequence and a downstream Renilla luciferase (RLuc) sequence. Transfection with this plasmid results in overexpression of GAPDH and in RLuc production as a measure of IRES activity. RLuc activity was compared with that from a control, null-expression plasmid that was identical except for a frameshift mutation within the 5′ GAPDH coding sequence. In transfection experiments, GAPDH overexpression significantly suppressed HAV IRES activity in BSC-1 and FRhK-4 cells but not in Huh-7 cells, which have a significantly greater cytoplasmic abundance of PTB. GAPDH suppression of HAV translation was greater with the wild-type HAV IRES than with the IRES from a cell culture-adapted virus (HM175/P16) that has reproducibly higher basal translational activity in BSC-1 cells. Stem-loop IIIa RNA from the latter IRES had significantly lower affinity for GAPDH in filter binding experiments. Thus, the binding of GAPDH to the IRES of HAV suppresses cap-independent viral translation in vivo in African green monkey kidney cells. The enhanced replication capacity of cell culture-adapted HAV in such cells may be due in part to reduced affinity of the viral IRES for GAPDH.
An approach for minimal surface family passing a curve
Creators: name: Kahyaoğlu, Sedat
name: Kasap, Emin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We investigate minimal surfaces passing a given curve in $R^{3}$. Using the Frenet frame of a given curve and isothermal parameter, we derive the necessary and sufficient condition for minimal surface. Also we derive the parametric representation of two minimal surface families passing a circle and a helix as examples.
Strong effects of weak ac driving in short superconducting junctions
Creators: name: Riwar, Roman-Pascal
name: Houzet, Manuel
name: Meyer, Julia S.
name: Nazarov, Yuli V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study a short superconducting junction subject to a dc and ac phase bias. The ac modulation changes the occupation of the Andreev bound states formed at the constriction by transitions between bound states and the continuum. In a short junction, the non-equilibrium Andreev bound state population may relax through processes that conserve parity of the occupation number on the same bound state and processes that do not conserve it. We argue that the parity conserving processes occur on a much faster time scale. In this case, even a weak driving may lead to a large deviation of the supercurrent from its equilibrium value. We show that this effect is accompanied by a quasiparticle current which may lead to a measurable charge imbalance in the vicinity of the junction. Furthermore, we study the time evolution of the supercurrent after switching off the ac drive. On a time scale where parity relaxation is negligible, the supercurrent relaxes to a stationary non-equilibrium state. Finally, we briefly outline the regime of ultraweak driving where the ac-induced processes occur on a time scale comparable to parity relaxation.
description: 13 pages, 11 figures
Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors
Creators: name: Bartlett, J. S.
name: Samulski, R. J.
name: Wilcher, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: We have investigated the infectious entry pathway of adeno-associated virus (AAV) and recombinant AAV vectors by assessing AAV-mediated gene transfer and by covalently conjugating fluorophores to AAV and monitoring entry by fluorescence microscopy. We examined AAV entry in HeLa cells and in HeLa cell lines which inducibly expressed a dominant interfering mutant of dynamin. The data demonstrate that AAV internalizes rapidly by standard receptor-mediated endocytosis from clathrin-coated pits (half-time 1 prevent AAV-mediated gene transfer when present during the first 30 min after the onset of endocytosis, indicating that AAV escapes from early endosomes yet requires an acidic environment for penetration into the cytosol. Following release from the endosome, AAV rapidly moves to the cell nucleus and accumulates perinuclearly beginning within 30 min after the onset of endocytosis. We present data indicating that escape of AAV from the endosome and trafficking of viral particles to the nucleus are unaffected by the presence of adenovirus, the primary helper virus for a productive AAV infection. Within 2 h, viral particles could be detected within the cell nucleus, suggesting that AAV enters the nucleus prior to uncoating. Interestingly, the majority of the intracellular virus particles remain in a stable perinuclear compartment even though gene expression from nuclear AAV genomes can be detected. This suggests that the process of nuclear entry is rate limiting or that AAV entry involves multiple pathways. Nevertheless, these data establish specific points in the AAV infectious entry process and have allowed the generation of a model for future expansion to specific cell types and AAV vector analysis in vivo.
Interferon Regulatory Factor 7 Is Induced by Epstein-Barr Virus Latent Membrane Protein 1
Creators: name: Zhang, L.
name: Pagano, J. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Infection by Epstein-Barr virus (EBV) generates several types of latency with different profiles of gene expression but with expression of Epstein-Barr nuclear antigen 1 (EBNA-1) in common. The BamHI Q promoter (Qp) is used for the transcription of EBNA-1 mRNA in type I latency, which is an EBV infection state exemplified by Burkitt's lymphoma (BL). However, Qp is inactive in type III latency, and other promoters (C/Wp) are used for transcription of EBNA-1, which raises the question of how usage of these promoters is governed. Interferon (IFN) regulatory factor 7 (IRF-7) was identified first as a negative regulator of Qp. Expression of IRF-7 is associated with EBV type III latency, where Qp is inactive, but not with type I latency, raising the possibility that a viral gene product(s) expressed in type III latency might induce IRF-7 and repress Qp. Here, detailed analysis of the expression of IRF-7 revealed that it is associated with the expression of EBV latent membrane protein 1 (LMP-1) and that LMP-1 stimulates the expression of IRF-7 in type III latency in which Qp is inactive. In contrast, LMP-1 is not expressed in type I latency cells in which Qp is active. LMP-1 represses the constitutive activity of Qp reporter constructs. Mutational analysis of Qp reporter constructs revealed that the Qp IFN-stimulated response element (ISRE) is essential for the repression by LMP-1. Furthermore, LMP-1 reduced EBNA-1 mRNA derived from Qp only in type I cells in which IRF-7 could be induced. Finally, IFN-α, but not IFN-γ, repressed endogenous Qp activity, which is consistent with the ability of IFN-α to induce IRF-7. Thus, IRF-7 may mediate repression of Qp by LMP-1. The induction of IRF-7 by LMP-1 may be relevant to the silencing of Qp in EBV type III latency.
Self-organisation and non-linear dynamics in driven magnetohydrodynamic turbulent flows
Creators: name: Dallas, Vassilios
name: Alexakis, Alexandros
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Magnetohydrodynamic turbulent flows driven by random mechanical and electromagnetic external forces of zero helicities are investigated by means of direct numerical simulations. It is shown that despite the absence of helicities in the forcing, the system is attracted to self-organized helical states that exhibit laminar behaviour despite the large value of the Reynolds numbers examined. We demonstrate that the correlation time of the external forces is controlling the time spent on these states, i.e. for short correlation times the system remains in the turbulent state while as the correlation time is increased the system spends more and more time in the self-organised states. As a result, time averaged statistics can significantly be affected by the time spent on these states. These results have important theoretical implications for the understanding of the suppression of non-linearities in plasma fusion devises as well as in astrophysical observations.
description: 7 pages, 6 figures
Latest heavy ion results from PHENIX at RHIC
Creators: name: Sakaguchi, Takao
Publisher: name: Zenodo
Year: 2023
Subjects: pic23
phenix
photon
direct photon
au+au
multiplicity
scaling
elliptic
flow
dielectron
charmonium
J/Ψ
nuclear
modification
raa
small systems
p+au
d+au
p+p
cu+au
u+u
φ
hadron
kaon
pion
π0
centrality
heavy flavor
zdc

description: Talk presented at the Physics in Collision 2023 conference
Kinetics of Recombinant Adeno-Associated Virus-Mediated Gene Transfer
Creators: name: Allen, D. L.
name: Chen, B.-G.
name: Kurachi, K.
name: Samulski, R. J.
name: Monahan, P. E.
name: Malik, A. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Recombinant adeno-associated virus (rAAV) vectors have been shown to be useful for efficient gene delivery to a variety of dividing and nondividing cells. Mechanisms responsible for the long-term, persistent expression of the rAAV transgene are not well understood. In this study we investigated the kinetics of rAAV-mediated human factor IX (hFIX) gene transfer into human primary myoblasts and myotubes. Transduction of both myoblasts and myotubes occured with a similar and high efficiency. After 3 to 4 weeks of transduction, rAAV with a cytomegalovirus (CMV) promoter showed 10- to 15-fold higher expression than that with a muscle-specific creatine kinase enhancer linked to β-actin promoter. Factor IX expression from transduced myoblasts as well as myotubes reached levels as high as approximately 2 μg of hFIX/106 cells/day. Southern blot analyses of high-molecular-weight (HMW) cellular genomic and Hirt DNAs isolated from rAAV/CMVhFIXm1-transduced cells showed that the conversion of single-stranded vector genomes to double-stranded DNA forms, but not the level of the integrated forms in HMW DNA, correlated with increasing expression of the transgene. Together, these results indicate that rAAV can transduce both proliferating and terminally differentiated muscle cells at about the same efficiency, that expression of transgenes increases linearly over their lifetime with no initial lag phase, and that increasing expression correlates with the appearance of double-stranded episomal rAAV genomes. Evidence showing that the rAAV virions can copackage hFIX, presumably nonspecifically, was also obtained.
title: Dal caos al caosmo attraverso l’arte
Creators: name: Angelucci , Daniela
Publisher: name: Roma Tre-Press
Year: 2012

description: L'articolo prende le mosse dall'ultimo libro pubblicato in vita da Gilles Deleuze insieme a Felix Guattari, Che cos'è la filosofia?, per indagare in che modo questi autori concepiscano la filosofia, la scienza e l'arte come mezzi per affrontare il caos.

description: B@belonline vol. 13 Chaos/Kosmos
High precision poverty maps
Creators: name: Esteve, A.
name: Permanyer, I.
name: Tzavidis, N.
name: Köksel, P.
name: Liu, C.
Publisher: name: Zenodo
Year: 2017
Subjects: poverty
maps

description: Abstract: Estimating economic indicators is crucial for achieving a targeted implementation of welfare policies. However, for such policies to be effective, policy makers must have access to a detailed picture of deprivation that goes beyond aggregate estimates at the country (national) level, extending to finer geographical levels and to other domains of interest, such as specific groups of individuals. In this context, we have estimated the regional distribution of poverty and inequality across several Euro­pean countries using the most recently available data from European censuses and the EU-SILC household surveys. The main goal of this exercise has been to generate poverty maps (via the so-called ‘Empirical Best Prediction’ (EBP) approach) with the highest geographical precision that the available data permitted, in as many countries as possible.
Quantitation of CD8+ T-Lymphocyte Responses to Multiple Epitopes from Simian Virus 40 (SV40) Large T Antigen in C57BL/6 Mice Immunized with SV40, SV40 T-Antigen-Transformed Cells, or Vaccinia Virus Recombinants Expressing Full-Length T Antigen or Epitope Minigenes
Creators: name: Collins, E. J.
name: Joyce, S.
name: Mylin, L. M.
name: Frelinger, J. A.
name: Boesteanu, A.
name: Schell, T. D.
name: Roberts, D.
name: Epler, M.
name: Tevethia, S. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The cytotoxic T-lymphocyte response to wild-type simian virus 40 large tumor antigen (Tag) in C57BL/6 (H2b) mice is directed against three H2-Db-restricted epitopes, I, II/III, and V, and one H2-Kb-restricted epitope, IV. Epitopes I, II/III, and IV are immunodominant, while epitope V is immunorecessive. We investigated whether this hierarchical response was established in vivo or was due to differential expansion in vitro by using direct enumeration of CD8+ T lymphocytes with Tag epitope/major histocompatibility complex class I tetramers and intracellular gamma interferon staining. The results demonstrate that epitope IV-specific CD8+ T cells dominated the Tag-specific response in vivo following immunization with full-length Tag while CD8+ T cells specific for epitopes I and II/III were detected at less than one-third of this level. The immunorecessive nature of epitope V was apparent in vivo, since epitope V-specific CD8+ T cells were undetectable following immunization with full-length Tag. In contrast, high levels of epitope V-specific CD8+ T lymphocytes were recruited in vivo following immunization and boosting with a Tag variant in which epitopes I, II/III, and IV had been inactivated. In addition, analysis of the T-cell receptor β (TCRβ) repertoire of Tag epitope-specific CD8+ cells revealed that multiple TCRβ variable regions were utilized for each epitope except Tag epitope II/III, which was limited to TCRβ10 usage. These results indicate that the hierarchy of Tag epitope-specific CD8+ T-cell responses is established in vivo.
Heavy flavor puzzle at RHIC: analysis of the underlying effects
Creators: name: Djordjevic, Magdalena
name: Djordjevic, Marko
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Suppressions of light and heavy flavor observables are considered to be excellent probes of QCD matter created in ultra-relativistic heavy ion collisions. Suppression predictions of quark and gluon jets appear to suggest a clear hierarchy according to which neutral pions should be more suppressed than D mesons, which in turn should be more suppressed than single electrons. However, joint comparison of neutral pion (light probe) and non-photonic single electron (heavy probe) suppression data at RHIC unexpectedly showed similar jet suppression for these two probes, which presents the well-known heavy flavor puzzle at RHIC. We here analyze which effects are responsible for this unexpected result, by using the dynamical energy loss formalism. We find that the main effect is a surprising reversal in the suppression hierarchy between neutral pions and D mesons, which is due to the deformation of the suppression patterns of light partons by fragmentation functions. Furthermore, we find that, due to the decay functions, the single electron suppression approaches the D meson suppression. Consequently, we propose that these two effects, taken together, provide a clear intuitive explanation of this longstanding puzzle.
description: 6 pages, 6 figures
Super-Gaussian conical refraction beam
Creators: name: Turpin, A.
name: Loiko, Yu. V.
name: Kalkandkiev, T. K.
name: Tomizawa, H.
name: Mompart, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate the transformation of Gaussian input beams into super-Gaussian beams with a quasi flat-top transverse profile by means of the conical refraction phenomenon by adjusting the ratio between the ring radius and the waist radius of the input beam to 0.445. We discuss the beam propagation of the super-Gaussian beam and show that it has a confocal parameter three times larger than the one that would be obtained from a Gaussian beam. The experiments performed with a KGd(WO4)2 biaxial crystal are in good agreement with the theoretical predictions.
Three loop HTL perturbation theory at finite temperature and chemical potential
Creators: name: Strickland, Michael
name: Andersen, Jens O.
name: Bandyopadhyay, Aritra
name: Haque, Najmul
name: Mustafa, Munshi G.
name: Su, Nan
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this proceedings contribution we present a recent three-loop hard-thermal-loop perturbation theory (HTLpt) calculation of the thermodynamic potential for a finite temperature and chemical potential system of quarks and gluons. We compare the resulting pressure, trace anomaly, and diagonal/off-diagonal quark susceptibilities with lattice data. We show that there is good agreement between the three-loop HTLpt analytic result and available lattice data.
description: 4 pages, 4 figures
In situ SANS analysis to investigate the electric field alignment of Silver-based Solvate Ionic Liquid (SIL) and Silver Nanoparticles (AgNPs) in nanocomposites
Creators: name: Al-Qatatsheh, Ahmed
name: Sokolova, Anna
name: Hameed, Nishar
Publisher: name: figshare
Year: 2022
Subjects: subject: 100708 Nanomaterials
subject: FOS: Nanotechnology

description: The structural design of composite matrices is necessary to optimize electrical, mechanical, and thermal properties for smart applications in various industries, including aerospace, defence, and MedTech. The induced electrical or magnetic field alignment of anisotropic fillers (e.g., Ag, Graphene) or SIL has drawn attention since they can boost composites’ performance. For example, the enhance- ment in bulk electrical conductivity of aligned Ag nanoparticles (AgNPs) in a composite matrix can be five orders of magnitude, converting the sample conductivity from polymer-dominated to silver- dominated. Our work presents a comprehensive study of the impact of alignment changes of Ag (I) and AgNPs in various composite matrices under the externally applied electric field and assess the alignment’s sta- bility after the electric field is permanently removed. We studied the effect of directional alignment on creating the high crosslinked density regionsin composite matrices. Furthermore, We evalu- ated the contributions of the high crosslinked density segments and the hierarchical structure of the aligned complexes and composite matrices’ properties and performance. In addition to the utilization of the Infrared macrospectroscopy beamline to evaluate the directional alignment using the four-angle approach, we used SANS to study the kinetic effects under external impulse influence since SANS data helped identify the clusters of Ag under an external electric field in various composite matrices. We also applied computational modeling based on quantum mechanics to validate investigation outcomes and reveal the uniqueness of the composite structure responsible forthe superior properties.
Retargeting the Coxsackievirus and Adenovirus Receptor to the Apical Surface of Polarized Epithelial Cells Reveals the Glycocalyx as a Barrier to Adenovirus-Mediated Gene Transfer
Creators: name: Bergelson, J. M.
name: Pickles, R. J.
name: Boucher, R. C.
name: Fahrner, J. A.
name: Petrella, J. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Lumenal delivery of adenovirus vectors (AdV) results in inefficient gene transfer to human airway epithelium. The human coxsackievirus and adenovirus receptor (hCAR) was detected by immunofluorescence selectively at the basolateral surfaces of freshly excised human airway epithelial cells, suggesting that the absence of apical hCAR constitutes a barrier to adenovirus-mediated gene delivery in vivo. In transfected polarized Madin-Darby canine kidney cells, wild-type hCAR was expressed selectively at the basolateral membrane, whereas hCAR lacking the transmembrane and/or cytoplasmic domains was expressed on both the basolateral and apical membranes. Cells expressing apical hCAR still were not efficiently transduced by AdV applied to the apical surface. However, after the cells were treated with agents that remove components of the apical surface glycocalyx, AdV transduction occurred. These results indicate that adenovirus can infect via receptors located at the apical cell membrane but that the glycocalyx impedes interaction of AdV with apical receptors.
Two gamma-ray bursts from dusty regions with little molecular gas
Creators: name: Hatsukade, B.
name: Ohta, K.
name: Endo, A.
name: Nakanishi, K.
name: Tamura, Y.
name: Hashimoto, T.
name: Kohno, K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Long-duration gamma-ray bursts are associated with the explosions of massive stars and are accordingly expected to reside in star-forming regions with molecular gas (the fuel for star formation). Previous searches for carbon monoxide (CO), a tracer of molecular gas, in burst host galaxies did not detect any emission. Molecules have been detected as absorption in the spectra of gamma-ray burst afterglows, and the molecular gas is similar to the translucent or diffuse molecular clouds of the Milky Way. Absorption lines probe the interstellar medium only along the line of sight, so it is not clear whether the molecular gas represents the general properties of the regions where the bursts occur. Here we report spatially resolved observations of CO line emission and millimetre-wavelength continuum emission in two galaxies hosting gamma-ray bursts. The bursts happened in regions rich in dust, but not particularly rich in molecular gas. The ratio of molecular gas to dust (<9-14) is significantly lower than in star-forming regions of the Milky Way and nearby star-forming galaxies, suggesting that much of the dense gas where stars form has been dissipated by other massive stars.
description: To appear in Nature June 12, 2014. 17 pages, 4 figures and 1 table, including Methods section, Extended Data Figures, and Supplementary Information
The abstract quasilinear Cauchy problem for a MEMS model with two free boundaries
Creators: name: Kohlmann, Martin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35R35, 35M33, 35B30, 35Q74, 74M05

description: In this paper, we reformulate a mathematical model for the dynamics of an idealized electrostatically actuated MEMS device with two elastic membranes as an initial value problem for an abstract quasilinear evolution equation. Applying the Contraction Mapping Theorem, it is shown that the model is locally well-posed in time for any value of the source voltage of the device. In addition it is proven that the MEMS model considered here possesses global solutions for small source voltages whereas for large source voltages solutions of the model have a finite maximal existence time. Furthermore, we comment on the relationship of our model to its stationary version and to its small aspect ratio limit by showing that there exists a unique exponentially stable steady state and by proving convergence towards a solution of the narrow gap model in the vanishing aspect ratio limit. Our results extend the discussion of the elliptic-parabolic MEMS model presented in [Martin Kohlmann: On an elliptic-parabolic MEMS model with two free boundaries, 2014] leading to a Cauchy problem for a semilinear abstract evolution equation.
description: 27 pages; to appear in Acta Applicandae Mathematicae
Isolating electrons on superfluid helium
Creators: name: Takita, Maika
name: Lyon, S. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Electrons floating on the surface of superfluid helium have been suggested as promising mobile spin quantum bits (qubits). Transferring electrons extremely efficiently in a narrow channel structure with underlying gates has been demonstrated, showing no transfer error while clocking $10^9$ pixels in a 3-phase charge coupled device (CCD). While on average, one electron per channel was clocked, it is desirable to reliably obtain a single electron per channel. We have designed an electron turnstile consisting of a narrow (0.8$μ$m) channel and narrow underlying gates (0.5$μ$m) operating across seventy-eight parallel channels. Initially, we find that more than one electron can be held above the small gates. Underlying gates in the turnstile region allow us to repeatedly split these electron packets. Results show a plateau in the electron signal as a function of the applied gate voltages, indicating quantization of the number of electrons per pixel, simultaneously across the seventy-eight parallel channels.
MPEC 2023-U238 : 2023 UT8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 UT8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
APLICATIVO STORYBOARDTHAT NAS AULAS DE HISTÓRIA DOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Creators: name: Silva, Geovana Bezerra
name: Pereira, Suellen Raissa Alves
name: Carlos, Yasmine Alves De Melo
name: De Souza, Dayse Cristine Dantas Brito Neri
name: Souza, Francisle Neri
Publisher: name: Internet Latent Corpus Journal
Year: 2023

description: Considerando os avanços e mudanças na sociedade, principalmente no que se refere à integração da tecnologia, percebe-se como necessário a inserção dessas ferramentas no âmbito educacional de forma a beneficiar o processo de ensino e de aprendizagem. Tal necessidade tornou-se ainda mais evidente com a pandemia COVID-19, que acarretou o fechamento de escolas, fazendo com que o uso das TIC fosse indispensável. O objetivo deste trabalho é analisar os benefícios pedagógicos do uso do aplicativo storyboardthat nas aulas de História do 5º ano do Ensino Fundamental. Esta pesquisa contou com a colaboração de 15 participantes, sendo 14 alunos do 5º ano dos anos iniciais e uma professora de um colégio particular localizado no interior de São Paulo. Trata-se de uma pesquisa qualitativa com o paradigma interpretativista. A fim de verificar a eficácia da ferramenta, foi aplicado um questionário de sondagem (Google Forms) aos alunos para caracterizar o nível de letramento tecnológico, e uma entrevista com a professora da turma. Em seguida foi realizada uma atividade, na aula de História, com o uso da referida ferramenta a fim de verificar se ela de fato facilitava ou não a aprendizagem de determinado conteúdo. Logo após, foi requerido dos participantes que avaliassem a efetividade da estratégia pedagógica por meio de um questionário e entrevista à professora. Ao final, o estudo deixa evidente que tanto os alunos como a professora têm familiaridade com as tecnologias e utilizam em casa e no ambiente escolar. Afirmaram que o uso do computador e da internet podem melhorar o processo de ensino e aprendizagem e que, na disciplina de História, o apoio do aplicativo storyboardthat, proporcionou interesse aos alunos e colaborou na apreensão do conteúdo abordado por meio da criação de histórias em quadrinhos.
description: Internet Latent Corpus Journal, vol. 13 n.º 1 (2023): REPENSANDO A TECNOLOGIA NA EDUCAÇÃO
Strongly bound yet light bipolarons for double-well electron-phonon coupling
Creators: name: Adolphs, Clemens PJ
name: Berciu, Mona
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use the Momentum Average approximation (MA) to study the ground-state properties of strongly bound bipolarons in the double-well electron-phonon (el-ph) coupling model, which describes certain intercalated lattices where the linear term in the el-ph coupling vanishes due tosymmetry. We show that this model predicts the existence of strongly bound yet lightweight bipolarons in some regions of the parameter space. This provides a novel mechanism for the appearance of such bipolarons, in addition to long-range el-ph coupling and special lattice geometries.
description: 7 pages, 7 figures
Blondel et les oscillations auto-entretenues
Creators: name: Ginoux, Jean-Marc
name: Lozi, René
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In 1893, the "physicist-engineer" André Blondel invents the oscilloscope for displaying voltage and current variables. With this powerful means of investigation, he first studies the phenomena of the arc then used for the coastal and urban lighting and then, the singing arc used as a transmitter of radio waves in wireless telegraphy. In 1905, he highlights a new type of non-sinusoidal oscillations in the singing arc. Twenty years later, Balthasar van der Pol will recognize that such oscillations were in fact "relaxation oscillations". To explain this phenomenon, he uses a representation in the phase plane and shows that its evolution takes the form of small cycles. During World War I the triode gradually replaces the singing arc in transmission systems. At the end of the war, using analogy, Blondel transposes to the triode most of the results he had obtained for the singing arc. In April 1919, he publishes a long memoir in which he introduces the terminology "self-sustained oscillations" and proposes to illustrate this concept starting from the example of the Tantalus cup which is then picked up by Van der Pol and Philippe Le Corbeiller. He then provides the definition of a self sustained system which is quite similar to that given later by Aleksandr Andronov and Van der Pol. To study the stability of oscillations sustained by the triode and by the singing arc he uses, this time, a representation in the complex plane and he expresses the amplitude in polar coordinates. He then justifies the maintaining of oscillations by the existence cycles which nearly present all the features of Poincaré's limit cycles. Finally, in November 1919, Blondel performs, a year before Van der Pol, the setting in equation of the triode oscillations. In March 1926, Blondel establishes the differential equation characterizing the oscillations of the singing arc, completely similar to that obtained concomitantly by Van der Pol for the triode. Thus, throughout his career, Blondel, has made fundamental and relatively unknown contributions to the development of the theory of nonlinear oscillations. The purpose of this article is to analyze his main work in this area and to measure their importance or influence by placing them in the perspective of the development of this theory.
description: in French
Sequence Heterogeneity of TT Virus and Closely Related Viruses
Creators: name: Chang, J.
name: Viazov, S. O.
name: Dou, X.-G.
name: Fried, M. W.
name: Cong, M.-e.
name: Nichols, B.
name: Reed, D.
name: Lambert, S.
name: Khudyakov, Y. E.
name: Roggendorf, M.
name: Fields, H. A.
name: Bower, W.
name: Williams, I.
name: Purdy, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: TT virus (TTV) is a recently discovered infectious agent originally obtained from transfusion-related hepatitis. However, the causative link between the TTV infection and liver disease remains uncertain. Recent studies demonstrated that genome sequences of different TTV strains are significantly divergent. To assess genetic heterogeneity of the TTV genome in more detail, a sequence analysis of PCR fragments (271 bp) amplified from open reading frame 1 (ORF1) was performed. PCR fragments were amplified from 5 to 40% of serum specimens obtained from patients with different forms of hepatitis who reside in different countries (e.g., China, Egypt, Vietnam, and the United States) and from normal human specimens obtained from U.S. residents. A total of 170 PCR fragments were sequenced and compared to sequences derived from the corresponding TTV genome region deposited in GenBank. Genotypes 2 and 3 were found to be significantly more genetically related than any other TTV genotype. Moreover, three sequences were shown to be almost equally related to both genotypes 2 and 3. These observations suggest a merger of genotypes 2 and 3 into one genotype, 2/3. Additionally, five new groups of TTV sequences were identified. One group represents a new genotype, whereas the other four groups were shown to be more evolutionary distant from all known TTV sequences. The evolutionary distances between these four groups were also shown to be greater than between TTV genotypes. The phylogenetic analysis suggested that these four new genetic groups represent closely related yet different viral species. Thus, TTV exists as a “swarm” of at least five closely related but different viruses. These observations suggest a high degree of genetic complexity within the TTV population. The finding of the additional TTV-related species should be taken into consideration when the association between TTV infections and human diseases of unknown etiology is studied.
INTELIGÊNCIA ARTIFICIAL NA EDUCAÇÃO
Creators: name: Martins, Rodrigo Henrique
name: Viana, Helena Brandão
Publisher: name: Internet Latent Corpus Journal
Year: 2023

description: A Inteligência Artificial (IA) recebeu atenção substancial no século XXI de relevantes interesses comerciais, pesquisadores, governos e o público em geral. No entanto, pouca atenção pública tem sido dada a outras áreas da IA, na política social e, especialmente, na educação. Dado o rápido crescimento da IA, há uma necessidade de entender como os educadores podem utilizar suas técnicas para o sucesso acadêmico dos alunos dentro do ambiente acadêmico, onde muitas vezes não existem equipamento de apoio para uso de recursos tecnológicos nas salas de aulas, já que IA alcançou todas as camadas de nossas vidas, e a educação não está imune aos seus efeitos. Neste sentido, esta pesquisa teve como objetivo conduzir uma revisão integrativa da literatura para mostrar estudos sobre Inteligência Artificial na Educação, e para isso foram acessadas as bases de dados Education Resources Information Center (ERIC), Periódicos Capes e Scielo, utilizando método integrado com os seguintes descritores: Inteligência Artificial and educação (idioma em português para a base de dados periódicos capes e Artificial Intelligence and education para base de dados ERIC e Scielo), no período de 2018 a 2023, nos idiomas: inglês, português e espanhol. A partir da coleta de dados, foram encontrados 67 artigos, sendo 13 utilizados para estudo desse tema. Entretanto foi observado que ainda há poucos estudos sobre inteligência artificial na educação, principalmente no Brasil.
description: Internet Latent Corpus Journal, vol. 12 n.º 2 (2022): AUTOMAÇÃO DOS SERVIÇOS EDUCACIONAIS E O FUTURO DAS UNIVERSIDADES
An overview of jets and outflows in stellar mass black holes
Creators: name: Fender, Rob
name: Gallo, Elena
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this book chapter, we will briefly review the current empirical understanding of the relation between accretion state and and outflows in accreting stellar mass black holes. The focus will be on the empirical connections between X-ray states and relativistic (`radio') jets, although we are now also able to draw accretion disc winds into the picture in a systematic way. We will furthermore consider the latest attempts to measure/order jet power, and to compare it to other (potentially) measurable quantities, most importantly black hole spin.
description: Accepted for publication in Space Science Reviews. Also to appear in the Space Sciences Series of ISSI - The Physics of Accretion on to Black Holes (Springer Publisher)
title: Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
Creators: name: Graf, Monika
name: Interlandi, Marta
name: Moreno, Natalia
name: Holdhof, Dörthe
name: Göbel, Carolin
name: Melcher, Viktoria
name: Mertins, Julius
name: Albert, Thomas
name: Kastrati, Dennis
name: Alfert, Amelie
name: Holsten, Till
name: de Faria, Flavia W.
name: Meisterernst, Michael
name: Rössig, Claudia
name: Warmuth-Metz, Monika
name: Nowak, Johannes
name: Meyer zu Hörste, Gerd
name: Mayère, Chloe
name: Nef, Serge
name: Johann, Pascal-David
name: Frühwald, Michael
name: Dugas, Martin
name: Schüller, Ulrich
name: Kerl, Kornelius Tobias
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 610 Medicine and health

description: Rhabdoid tumors (RT) are rare and highly aggressive pediatric neoplasms. Their epigenetically-driven intertumoral heterogeneity is well described; however, the cellular origin of RT remains an enigma. Here, we establish and characterize different genetically engineered mouse models driven under the control of distinct promoters and being active in early progenitor cell types with diverse embryonic onsets. From all models only Sox2-positive progenitor cells give rise to murine RT. Using single-cell analyses, we identify distinct cells of origin for the SHH and MYC subgroups of RT, rooting in early stages of embryogenesis. Intra- and extracranial MYC tumors harbor common genetic programs and potentially originate from fetal primordial germ cells (PGCs). Using PGC specific Smarcb1 knockout mouse models we validate that MYC RT originate from these progenitor cells. We uncover an epigenetic imbalance in MYC tumors compared to PGCs being sustained by epigenetically-driven subpopulations. Importantly, treatments with the DNA demethylating agent decitabine successfully impair tumor growth in vitro and in vivo. In summary, our work sheds light on the origin of RT and supports the clinical relevance of DNA methyltransferase inhibitors against this disease.
description: Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022.
TECNOLOGIAS, EDUCAÇÃO E INOVAÇÃO PEDAGÓGICA
Creators: name: De Souza, Mariana Aranha
name: Dias, Vanessa Cristina
name: De Oliveira, Stenio Augusto
Publisher: name: Internet Latent Corpus Journal
Year: 2023

description: Este artigo tem por objetivo discutir a relação entre Tecnologia e Educação, no contexto das inovações pedagógicas. De natureza qualitativa, este estudo possui 125 participantes, professores de Ensino Fundamental e Médio de escolas particulares e públicas, que atuaram em aulas remoto durante o ano de 2020, em decorrência da pandemia do Covid-19 e que aceitaram participar desta pesquisa de forma voluntária. Todos responderam um questionário online, que teve por objetivo conhecer o perfil sociodemográfico dos docentes, sua formação acadêmica e atuação profissional, além de investigar qual a compreensão sobre inovações pedagógicas, como as veem em suas práticas educativas, na de seus colegas e/ou de outros professores a que tiveram conhecimento e como elas se relacionam (ou não) com tecnologias educacionais. Os resultados foram submetidos à técnica da análise de conteúdo e apontaram que, durante a pandemia os docentes utilizaram aplicativos e redes sociais como formas de comunicação com os alunos para um ensino remoto, sobretudo WhatsApp, Facebook, Instagram e e-mail. Parte significativa destes professores faz uso de mídias tecnológicas em suas aulas, com destaque para o uso de computador, projetor, celular e vídeo-aulas, privilegiando, ainda, aulas expositivas. Embora sinalizem que as ações voltadas para a inovação estejam voltadas à necessidade de usar recursos tecnológicos e mídias digitais, acreditam que inovação não é somente o uso de mídias, mas o desenvolvimento da criatividade e do estímulo ao aluno para seu aprendizado, além de um diálogo afetivo por parte do professor.
description: Internet Latent Corpus Journal, vol. 13 n.º 1 (2023): REPENSANDO A TECNOLOGIA NA EDUCAÇÃO
Strategy for Systematic Assembly of Large RNA and DNA Genomes: Transmissible Gastroenteritis Virus Model
Creators: name: Yount, B.
name: Baric, R. S.
name: Curtis, K. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: A systematic method was developed to assemble functional full-length genomes of large RNA and DNA viruses. Coronaviruses contain the largest single-stranded positive-polarity RNA genome in nature. The ∼30-kb genome, coupled with regions of genomic instability, has hindered the development of a full-length infectious cDNA construct. We have assembled a full-length infectious construct of transmissible gastroenteritis virus (TGEV), an important pathogen in swine. Using a novel approach, six adjoining cDNA subclones that span the entire TGEV genome were isolated. Each clone was engineered with unique flanking interconnecting junctions which determine a precise systematic assembly with only the adjacent cDNA subclones, resulting in an intact TGEV cDNA construct of ∼28.5 kb in length. Transcripts derived from the full-length TGEV construct were infectious, and progeny virions were serially passaged in permissive host cells. Viral antigen production and subgenomic mRNA synthesis were evident during infection and throughout passage. Plaque-purified virus derived from the infectious construct replicated efficiently and displayed similar plaque morphology in permissive host cells. Host range phenotypes of the molecularly cloned and wild-type viruses were similar in cells of swine and feline origin. The recombinant viruses were sequenced across the unique interconnecting junctions, conclusively demonstrating the marker mutations and restriction sites that were engineered into the component clones. Full-length infectious constructs of TGEV will permit the precise genetic modification of the coronavirus genome. The method that we have designed to generate an infectious cDNA construct of TGEV could theoretically be used to precisely reconstruct microbial or eukaryotic genomes approaching several million base pairs in length.
Continuous and inverse shadowing
Creators: name: Kloeden, Peter E.
name: Ombach, Jerzy
name: Pokrovskii, Alexei V.
Publisher: name: Weierstrass Institute
Year: 1997
Subjects: subject: shadowing lemma
subject: bishadowing
subject: semi-hyperbolicity
subject: 37C50
subject: 37D05

description: By the Shadowing Lemma we can shadow any sufficient accurate pseudo-trajectory of a hyperbolic system by a true trajectory of a hyperbolic system. If we are interested in finite trajectories, at least from one side, then a pseudo trajectory usually has many possible shadows. Here we show that we can choose a continuous single-valued selector from the corresponding multi-valued operator "pseudo-trajectory ↦ the totality of possible shadows". We do this in the context of Lipschitz mappings which are semi-hyperbolic on some compact subset, which need not be invariant. We also prove that semi-hyperbolicity implis inverse shadowing with respect to a very broad class of nonsmooth perturbations.
Subgenomic Negative-Strand RNA Function during Mouse Hepatitis Virus Infection
Creators: name: Baric, R. S.
name: Yount, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Mouse hepatitis virus (MHV)-infected cells contain full-length and subgenomic-length positive- and negative-strand RNAs. The origin and function of the subgenomic negative-strand RNAs is controversial. In this report we demonstrate that the synthesis and molar ratios of subgenomic negative strands are similar in alternative host cells, suggesting that these RNAs function as important mediators of positive-strand synthesis. Using kinetic labeling experiments, we show that the full-length and subgenomic-length replicative form RNAs rapidly accumulate and then saturate with label, suggesting that the subgenomic-length negative strands are the principal mediators of positive-strand synthesis. Using cycloheximide, which preferentially inhibits negative-strand and to a lesser extent positive-strand synthesis, we demonstrate that cycloheximide treatment equally inhibits full-length and subgenomic-length negative-strand synthesis. Importantly, following treatment, previously transcribed negative strands remain in transcriptionally active complexes even in the absence of new negative-strand synthesis. These findings indicate that the subgenomic-length negative strands are the principal templates of positive-strand synthesis during MHV infection.
A New Approach for Super resolution by Using Web Images and FFT Based Image Registration
Creators: name: Vijayan, Archana
name: Salam, Vincy
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Preserving accuracy is a challenging issue in super resolution images. In this paper, we propose a new FFT based image registration algorithm and a sparse based super resolution algorithm to improve the accuracy of super resolution image. Given a low resolution image, our approach initially extracts the local descriptors from the input and then the local descriptors from the whole correlated images using the SIFT algorithm. Once this is completed, it will compare the local descriptors on the basis of a threshold value. The retrieved images could be having different focal length, illumination, inclination and size. To overcome the above differences of the retrieved images, we propose a new FFT based image registration algorithm. After the registration stage, we apply a sparse based super resolution on the images for recreating images with better resolution compared to the input. Based on the PSSNR calculation and SSIM comparison, we can see that the new methodology creates a better image than the traditional methods.
description: 7 pages,4 figures,Published with International Journal of Engineering Trends and Technology (IJETT)