cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Future-year ozone prediction for the United States using updated models and inputs
Creators: name: Collet, Susan
name: Kidokoro, Toru
name: Karamchandani, Prakash
name: Tejas Shah
name: Jaegun Jung
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: The relationship between emission reductions and changes in ozone can be studied using photochemical grid models. These models are updated with new information as it becomes available. The primary objective of this study was to update the previous Collet et al. studies by using the most up-to-date (at the time the study was done) modeling emission tools, inventories, and meteorology available to conduct ozone source attribution and sensitivity studies. Results show future-year, 2030, design values for 8-hr ozone concentrations were lower than base-year values, 2011. The ozone source attribution results for selected cities showed that boundary conditions were the dominant contributors to ozone concentrations at the western U.S. locations, and were important for many of the eastern U.S. locations. Point sources were generally more important in the eastern United States than in the western United States. The contributions of on-road mobile emissions were less than 5 ppb at a majority of the cities selected for analysis. The higher-order decoupled direct method (HDDM) results showed that in most of the locations selected for analysis, NOx emission reductions were more effective than VOC emission reductions in reducing ozone levels. The source attribution results from this study provide useful information on the important source categories and provide some initial guidance on future emission reduction strategies. Implications: The relationship between emission reductions and changes in ozone can be studied using photochemical grid models, which are updated with new available information. This study was to update the previous Collet et al. studies by using the most current, at the time the study was done, models and inventory to conduct ozone source attribution and sensitivity studies. The source attribution results from this study provide useful information on the important source categories and provide some initial guidance on future emission reduction strategies.
One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin
Creators: name: Peng, Jianqing
name: Fumoto, Shintaro
name: Miyamoto, Hirotaka
name: Chen, Yi
name: Kuroda, Naotaka
name: Nishida, Koyo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Molecular Biology
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of the different water-solubility of these drugs. This study provides a strategy for the “one-step” formation of nanoparticles encapsulating both Dox and Cur. We took advantage of polyacrylic acid (PAA) and calcium carbonate (CaCO3) to realise a high drug entrapment efficiency (EE) and pH-sensitive drug release using a simplified preparation method. Optimisation of lipid ratios and concentrations of CaCO3 was conducted. Under optimal conditions, the mean diameter of PEGylated lipid/PAA/CaCO3 nanoparticles with encapsulated Cur and Dox (LPCCD) was less than 100 nm. An obvious pH-sensitive release of both drugs was observed, with different Dox and Cur release rates. Successful co-delivery of Cur and Dox was achieved via LPCCD on HepG2 cells. LPCCD altered the bio-distribution of Dox and Cur in vivo and decreased Dox-induced cardiotoxicity. The current investigation has developed an efficient ternary system for co-delivery of Dox and Cur to tumours, using a “one-step” formation resulting in nanoparticles possessing remarkable pH-sensitive drug release behaviour, which may be valuable for further clinical studies and eventual clinical application.
Coinage in Norway during the King Olav I Tryggvasonʼs reign (995 – 1000) / Возникновение денежного дела в Норвегии в эпоху викингов: пеннинги Улава I (995 – 1000)
Creators: name: Petrov, Alexander
Publisher: name: figshare
Year: 2017
Subjects: subject: History
subject: 140203 Economic History
subject: FOS: Economics and business
subject: Archaeology
subject: 150299 Banking, Finance and Investment not elsewhere classified

description: The article is about a decisive moment in the history of Norway and Russia – the Viking Age – and the very begynning of coinage in Norway.
For the first time in Russian numismatic historiography a paper has got all silver pennings minted during the reign of Viking King Olav I Tryggvason, who is equality venerated in Norway and Russia. The author believes that Norwegian imitations of the Anglo-Saxon silver penny “Crux” were hammered in Nidaros (Trondheim) by local silversmiths. Scandinavia had a long tradition of minting imitative coins, such as bracteates, which were used as jewellery.
There is reason to assume that the begynning of Vikings’ imitative “Crux” coinage in Norway happened in 997 – 998: Olav I Tryggvason had chosen Nidaros as a royal residence in 997, imitations of the new Anglo-Saxon penny “Long Cross” appeared in Scandinavia in 998 making “Crux” obsolete.
Copyright following the coin catalogue number (1, 2, 3, 4)
Первая монета: ©2015 Nationalmuseet av Danmark, København, фотограф Т.Б. Кристенсен / Christensen, Tine Bonde (лицензия CC BY-SA 2.5 DK). За отснятую монету признателен Tine Bonde Christensen, museumsinspektør.
Вторая монета: ©2015 Historiska Museet, Lunds Universitet, Sverige, за предоставление изображения монеты и разрешение на ее публикацию признателен Gitte Ingvardson, antikvarie i Nordisk Numismatik ved Lunds Universitets Historiska Museet. All Rights Reserved.
Третья монета из Kungliga Myntkabinettet (Stockholm): ©2015 Kulturhistorisk museum, Universitetet i Oslo, фотограф Л.-А. Чепстов-Лусти / Chepstow-Lusty, Lill-Ann (лицензия CC BY-SA 4.0)
Четвертая монета: ©2015 Münzkabinett, Staatliche Museen zu Berlin (лицензия CC BY-NC-SA 3.0 DE)
Autophagy enhanced the radioresistance of non-small cell lung cancer by regulating ROS level under hypoxia condition
Creators: name: Chen, Xiaoyan
name: Wang, Ping
name: Guo, Fei
name: Wang, Xiangdong
name: Wang, Juan
name: Xu, Jinping
name: Yuan, Dexiao
name: Zhang, Jianghong
name: Shao, Chunlin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Purpose: Tumor resistance towards radiation has been a big obstacle in the poor prognosis of lung cancer. It has been reported that hypoxia and autophagy partly contribute to this resistance. However, there is controversy over whether autophagy plays a positive role in cancer therapy or not. We aim to find out the specific mechanism of radiation resistance. Materials and methods: A549 cells were treated with conditioned medium (CM) under 12 h hypoxia or normoxia before irradiation, followed by the measurement of clonogenic survival, reactive oxygen species (ROS), signal of mitochondria and autophagy flux. In some experiments, the A549 cells were respectively transfected with LC3 small interfering RNA (siRNA), or treated with Earle’s Balanced Salt Solution (EBSS). Results: We found that hypoxia enhanced cell radioresistance by increasing the induction of autophagy. And after hypoxia stress, the number of mitochondria was reduced but the cellular ROS level was enhanced. It was significant that autophagy may enhance cell radioresistance by reducing ROS during hypoxic treatment. Conclusions: We elucidated the possible mechanisms of autophagy in regulating cancer cell death or survival. These results supply a new opinion about the intrinsic factor of radioresistance of hypoxia tumors.
Autophagy enhanced the radioresistance of non-small cell lung cancer by regulating ROS level under hypoxia condition
Creators: name: Chen, Xiaoyan
name: Wang, Ping
name: Guo, Fei
name: Wang, Xiangdong
name: Wang, Juan
name: Xu, Jinping
name: Yuan, Dexiao
name: Zhang, Jianghong
name: Shao, Chunlin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Purpose: Tumor resistance towards radiation has been a big obstacle to patient’s poor prognosis of lung cancer. It has been reported that hypoxia and autophagy are contributing to this resistance partly. However, there is controversy over whether autophagy plays positive role in cancer therapy or not. We aim to find out the specific mechanism of radiation resistance. Materials and methods: A549 cells were treated with conditioned medium (CM) under 12h hypoxia or normoxia before irradiation. And followed by the measurement of Clonogenic survival, reactive oxygen species (ROS), signal of mitochondria and autophagy flux .In some experiments, the A549 cells were respectively transfected with LC3 small interfering RNA (siRNA), or treated with Earle's Balanced Salt Solution (EBSS). Results: We found that hypoxia enhanced cell radioresistance by increasing the induction of autophagy. And after hypoxia stress, the number of mitochondria was reduced but the cellular ROS level was enhanced. Meaningful, autophagy may enhanced cell radioresistance by reducing ROS during hypoxic treatment. Conclusions: We elucidated the possible mechanisms of autophagy in regulating cancer cell death or survival. These results supply a new opinion about the intrinsic factor of radioresistance of hypoxia tumors.
Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide
Creators: name: Han, Zhipeng
name: Chen, Congcong
name: Meng, Caicai
name: Gao, Tian
name: Peng, Peng
name: Chen, Xi
name: Wang, Fengshan
name: Cao, Hongzhi
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: A highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.
Complexity of quantum circuits via sensitivity, magic, and coherence
Creators: name: Bu, Kaifeng
name: Garcia, Roy J.
name: Jaffe, Arthur
name: Koh, Dax Enshan
name: Li, Lu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Computational Complexity (cs.CC)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Quantum circuit complexity-a measure of the minimum number of gates needed to implement a given unitary transformation-is a fundamental concept in quantum computation, with widespread applications ranging from determining the running time of quantum algorithms to understanding the physics of black holes. In this work, we study the complexity of quantum circuits using the notions of sensitivity, average sensitivity (also called influence), magic, and coherence. We characterize the set of unitaries with vanishing sensitivity and show that it coincides with the family of matchgates. Since matchgates are tractable quantum circuits, we have proved that sensitivity is necessary for a quantum speedup. As magic is another measure to quantify quantum advantage, it is interesting to understand the relation between magic and sensitivity. We do this by introducing a quantum version of the Fourier entropy-influence relation. Our results are pivotal for understanding the role of sensitivity, magic, and coherence in quantum computation.
description: 42 pages
Tests of Simple Slopes in Multiple Regression Models with an Interaction: Comparison of Four Approaches
Creators: name: Liu, Yu
name: West, Stephen G.
name: Levy, Roy
name: Aiken, Leona S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Evolutionary Biology
subject: Ecology
subject: Mathematical Sciences not elsewhere classified

description: In multiple regression researchers often follow up significant tests of the interaction between continuous predictors X and Z with tests of the simple slope of Y on X at different sample-estimated values of the moderator Z (e.g., ±1 SD from the mean of Z). We show analytically that when X and Z are randomly sampled from the population, the variance expression of the simple slope at sample-estimated values of Z differs from the traditional variance expression obtained when the values of X and Z are fixed. A simulation study using randomly sampled predictors compared four approaches: (a) the Aiken and West (1991) test of simple slopes at fixed population values of Z, (b) the Aiken and West test at sample-estimated values of Z, (c) a 95% percentile bootstrap confidence interval approach, and (d) a fully Bayesian approach with diffuse priors. The results showed that approach (b) led to inflated Type 1 error rates and 95% confidence intervals with inadequate coverage rates, whereas other approaches maintained acceptable Type 1 error rates and adequate coverage of confidence intervals. Approach (c) had asymmetric rejection rates at small sample sizes. We used an empirical data set to illustrate these approaches.
Нові публікації дослідників КПІ ім. Ігоря Сікорського у Wed of Science (І квартал 2017 р.)
Creators: name: Library KPI Igor Sikorsky Kyiv Polytechnic Institute
Publisher: name: figshare
Year: 2017
Subjects: Uncategorized

description: New publications of researchers of the Igor Sikorsky Kyiv Politechnic Institute
The Uncertainty Effect in Innovation Diffusion: An Agent-Based Market Model with Opposing Information Sources
Creators: name: Tolkmitt, Frederik Jan
name: Stummer, Christian
Publisher: name: Universität Bielefeld, Center for Uncertainty Studies (CeUS)
Year: 2024
Subjects: subject: 330
subject: multi-agent systems
subject: innovation adoption
subject: consumer uncertainty
subject: market diffusion
subject: simulation experiment

description: When consumers are uncertain whether they have sufficient and unambiguous information regarding
a new product, they might delay the adoption decision to a later point in time. This
“uncertainty effect” can have a major impact on the product’s market diffusion. Prior models
that account for consumers’ belief updating in such a setting usually capture that effect by resorting
to some form of Bayesian learning and, in so doing, typically assume that the distribution
of information with respect to the attributes of the new product is normal and that the information
points received by individual consumers are independent draws from this distribution.
Consequently, consumers’ uncertainty regarding their beliefs decreases with more information
(e.g., after talking with a peer). This strong assumption is convenient as it makes models of
opinion dynamics analytically tractable, and it works in most instances. However, when inconsistent
information is provided from two opposing sources and, thus, receiving additional
information potentially increases uncertainty of individual consumers, a different approach is required.
Corresponding markets, for example, can be found for radically new products for which
consumers have strong opinions or as a result of a disinformation campaign by some competitor.
We propose an approach that can deal with such a setting and we demonstrate the value added
of this novel approach (in contrast to the traditional Bayesian approach) through computational
simulation experiments with an agent-based market model of innovation diffusion.
Нові публікації дослідників КПІ ім. Ігоря Сікорського у Scopus (I квартал 2017 р.)
Creators: name: Library KPI Igor Sikorsky Kyiv Polytechnic Institute
Publisher: name: figshare
Year: 2017
Subjects: Uncategorized

description: New publications of reasearchers of the Igor Sikorsky Kyiv Politechnic Institute.
Future Year Ozone Prediction for the United States Using Updated Models and Inputs
Creators: name: Collet, Susan
name: Kidokoro, Toru
name: Karamchandani, Prakash
name: Tejas Shah
name: Jaegun Jung
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: The relationship between emission reductions and changes in ozone can be studied using photochemical grid models. These models are updated with new information as it becomes available. The primary objective of this study was to update the previous Collet et al. studies by using the most up-to-date (at the time the study was done) modeling emission tools, inventories, and meteorology available to conduct ozone source attribution and sensitivity studies. Results show future-year, 2030, design values for 8-hr ozone concentrations were lower than base-year values, 2011. The ozone source attribution results for selected cities showed that boundary conditions were the dominant contributors to ozone concentrations at the western U.S. locations, and were important for many of the eastern U.S. locations. Point sources were generally more important in the eastern United States than in the western United States. The contributions of on-road mobile emissions were less than 5 ppb at a majority of the cities selected for analysis. The higher-order decoupled direct method (HDDM) results showed that in most of the locations selected for analysis, NOx emission reductions were more effective than VOC emission reductions in reducing ozone levels. The source attribution results from this study provide useful information on the important source categories and provide some initial guidance on future emission reduction strategies. Implications: The relationship between emission reductions and changes in ozone can be studied using photochemical grid models, which are updated with new available information. This study was to update the previous Collet et al. studies by using the most current, at the time the study was done, models and inventory to conduct ozone source attribution and sensitivity studies. The source attribution results from this study provide useful information on the important source categories and provide some initial guidance on future emission reduction strategies.
Monte Carlo simulations of a low energy proton beamline for radiobiological experiments
Creators: name: Dahle, Tordis J.
name: Rykkelid, Anne Marit
name: H. Stokkevåg, Camilla
name: Mairani, Andrea
name: Görgen, Andreas
name: Edin, Nina J.
name: Rørvik, Eivind
name: Fjæra, Lars Fredrik
name: Malinen, Eirik
name: S. Ytre-Hauge, Kristian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Background: In order to determine the relative biological effectiveness (RBE) of protons with high accuracy, radiobiological experiments with detailed knowledge of the linear energy transfer (LET) are needed. Cell survival data from high LET protons are sparse and experiments with low energy protons to achieve high LET values are therefore required. The aim of this study was to quantify LET distributions from a low energy proton beam by using Monte Carlo (MC) simulations, and to further compare to a proton beam representing a typical minimum energy available at clinical facilities. Materials and methods: A Markus ionization chamber and Gafchromic films were employed in dose measurements in the proton beam at Oslo Cyclotron Laboratory. Dose profiles were also calculated using the FLUKA MC code, with the MC beam parameters optimized based on comparisons with the measurements. LET spectra and dose-averaged LET (LETd) were then estimated in FLUKA, and compared with LET calculated from an 80 MeV proton beam. Results: The initial proton energy was determined to be 15.5 MeV, with a Gaussian energy distribution of 0.2% full width at half maximum (FWHM) and a Gaussian lateral spread of 2 mm FWHM. The LETd increased with depth, from approximately 5 keV/μm in the entrance to approximately 40 keV/μm in the distal dose fall-off. The LETd values were considerably higher and the LET spectra were much narrower than the corresponding spectra from the 80 MeV beam. Conclusions: MC simulations accurately modeled the dose distribution from the proton beam and could be used to estimate the LET at any position in the setup. The setup can be used to study the RBE for protons at high LETd, which is not achievable in clinical proton therapy facilities.
Нові публікації дослідників КПІ ім. Ігоря Сікорського у Wed of Science (за І квіртал 2017 р.)
Creators: name: Library KPI Igor Sikorsky Kyiv Polytechnic Institute
Publisher: name: figshare
Year: 2017
Subjects: Uncategorized

description: New publications of researchers of the Igor Sikorsky Kyiv Politechnic Institute
Original materials
Creators: name: Rux, Paul
name: Kaiser, Manuel
name: Kunz, Isabelle
name: Kohler, Antonia
name: Himstedt, Yannik
name: Weissgerber, Sophia C.
Publisher: name: OSF Registries
Year: 2019

description: Materials from the original study of Feng et al. (2013) provided by the original authors.
PEDAGOGICAL POSSIBILITIES OF TUTORING IN HIGHER EDUCATION INSTITUTIONS
Creators: name: Karimova, Nozik
Publisher: name: Zenodo
Year: 2025

description: This thesis analyzes the pedagogical possibilities of introducing and developing the tutoring system in higher education institutions. The role and importance of tutoring activities in supporting the personal and professional development of students, forming their independent learning skills, increasing their motivation, and effectively organizing the processes of social adaptation are scientifically highlighted. Also, the pedagogical conditions of tutoring activities, its functions based on modern requirements, and the requirements for the professional competence of tutors are analyzed.
Comparison of adsorption equilibrium models and error functions for the study of sulfate removal by calcium hydroxyapatite microfibrillated cellulose composite
Creators: name: Hokkanen, Sanna
name: Bhatnagar, Amit
name: Koistinen, Ari
name: Kangas, Teija
name: Lassi, Ulla
name: Sillanpää, Mika
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: In the present study, the adsorption of sulfates of sodium sulfate (Na2SO4) and sodium lauryl sulfate (SLS) by calcium hydroxyapatite-modified microfibrillated cellulose was studied in the aqueous solution. The adsorbent was characterized using elemental analysis, Fourier transform infrared, scanning electron microscope and elemental analysis in order to gain the information on its structure and physico-chemical properties. The adsorption studies were conducted in batch mode. The effects of solution pH, contact time, the initial concentration of sulfate and the effect of competing anions were studied on the performance of synthesized adsorbent for sulfate removal. Adsorption kinetics indicated very fast adsorption rate for sulfate of both sources (Na2SO4 and SLS) and the adsorption process was well described by the pseudo-second-order kinetic model. Experimental maximum adsorption capacities were found to be 34.53 mg g−1 for sulfates of SLS and 7.35 mg g−1 for sulfates of Na2SO4. The equilibrium data were described by the Langmuir, Sips, Freundlich, Toth and Redlich–Peterson isotherm models using five different error functions.
title: A blackbox yield estimation workflow with Gaussian process regression applied to the design of electromagnetic devices
Creators: name: Fuhrländer, Mona
name: Schöps, Sebastian
Publisher: name: Springer Nature
Year: 2022

description: In this paper an efficient and reliable method for stochastic yield estimation is presented. Since one main challenge of uncertainty quantification is the computational feasibility, we propose a hybrid approach where most of the Monte Carlo sample points are evaluated with a surrogate model, and only a few sample points are reevaluated with the original high fidelity model. Gaussian process regression is a non-intrusive method which is used to build the surrogate model. Without many prerequisites, this gives us not only an approximation of the function value, but also an error indicator that we can use to decide whether a sample point should be reevaluated or not. For two benchmark problems, a dielectrical waveguide and a lowpass filter, the proposed methods outperform classic approaches.
Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study
Creators: name: Erdemli, Mehmet Erman
name: Salmas, Ramin Ekhteiari
name: Durdagi, Serdar
name: Akgul, Hasan
name: Demirkol, Mehmet
name: Aksungur, Zeynep
name: Selamoglu, Zeliha
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: In the present study, the changes that occur in rat liver tissue as a result of the use of grape seed extract (GSE) and low level laser therapy (LLLT) in intraoral wound (IW) healing are analyzed using biochemical parameters. Diode laser application groups received 8 J/cm2 dose LLLT once a day for 4 days (810 nm wavelength, continuous mode, 0.25 W, 9 s). As a result of the biological parameter analysis, it was determined that the oxidative damage caused by the IWs and recovery period on 7th and 14th days could be substantially removed with GSE applications that have antioxidant capacity especially in rat liver tissue. In addition, the active compound of grape seed, catechin is studied in the active site of glycogen synthase kinase 3 (GSK3) target using molecular modeling approaches. Post-processing molecular dynamics (MD) results for catechin is compared with a standard GSK3 inhibitor. MD simulations assisted for better understanding of inhibition mechanism and the crucial amino acids contributing in the ligand binding. These results along with a through free energy analysis of ligands using sophisticated simulations methods are quite striking and it suggests a greater future role for simulation in deciphering complex patterns of molecular mechanism in combination with methods for understanding drug-receptor interactions.
Нові публікації дослідників КПІ ім. Ігоря Сікорського у Scopus
Creators: name: Library KPI Igor Sikorsky Kyiv Polytechnic Institute
Publisher: name: figshare
Year: 2017
Subjects: Uncategorized

description: New publications of reasearchers of the Igor Sikorsky Kyiv Politechnic Institute.
Formation of W/O Microemulsions in the Extraction of the Lanthanide Series by Purified Cyanex 301
Creators: name: Sun, Taoxiang
name: Xu, Chao
name: Chen, Jing
name: Duan, Wuhua
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The formation of water-in-oil (W/O) microemulsions during the extraction of the series of trivalent lanthanides Ln(III) by bis(2,4,4-trimethylpentyl)dithiophosphinic acid (HC301, also known as purified Cyanex 301) was studied. The phenomena in the formation of W/O microemulsions were similar in the extraction of all Ln(III) by HC301 at a high neutralization degree (50%), according to the measurement of the distribution ratios of Ln(III) and the concentrations of Na+ and NO3- in the organic phase, IR spectroscopy, and dynamic light scattering (DLS). W/O microemulsions also formed at a low neutralization degree (15%) for the extraction of heavy Ln(III). The coordination environment of the representative heavy lanthanide Ho(III) in the extracted complexes was monitored by absorption spectroscopy and extended X-ray absorption fine structure (EXAFS). Unlike the light lanthanide, Nd(III) and Ho(III) in the organic phase did not directly coordinate with the HC301 anions regardless of whether W/O microemulsions formed, which further demonstrated the different extraction behavior of HC301 toward the light lanthanides and the heavy lanthanides.
Resting-State Functional Connectivity Within Medial Prefrontal Cortex Mediates Age Differences in Risk Taking
Creators: name: Yu, Jing
name: Li, Rui
name: Guo, Yuhua
name: Fang, Fang
name: Duan, Suhuan
name: Lei, Xu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: To investigate the association between age-related changes in risk taking and resting-state functional activity, we recorded resting-state scans from both young (n = 26) and older adults (n = 27). In addition, all participants completed two decision-making tasks: the Cambridge Gambling Task and the Balloon Analogue Risk Task. We found that older adults showed decreased functional connectivity within the medial prefrontal cortex, particularly between the ventromedial prefrontal cortex and the dorsal medial prefrontal cortex. Moreover, these changes in resting-state functional connectivity were associated with the individuals’ risk-taking behavior, and mediated the influence of age on risk taking.
Supplementary material from Phosphatase UBLCP1 controls proteasome assembly
Creators: name: Sun, Shuangwu
name: Liu, Sisi
name: Zhang, Zhengmao
name: Zeng, Wang
name: Sun, Chuang
name: Tao, Tao
name: Lin, Xia
name: Feng, Xin-Hua
Publisher: name: The Royal Society
Year: 2017

description: Supplementary material
Synthesis, crystal structure, and photo/electrocatalytic properties of a 1D chain based on monocobalt-substituted arsenotungstates
Creators: name: Wu, Chu
name: Lv, Jinghua
name: Yu, Kai
name: Zhang, He
name: Wang, Chunmei
name: Wang, Chunxiao
name: Zhou, Baibin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Computational Biology

description: A chain based on the Keggin polyoxoanions, (H2bipy)2(Hbipy) [AsW11CoO39]·H2O (bipy = 4,4′-bipyridine) (1) has been hydrothermally synthesized and characterized by elemental analysis, IR, UV, TG, and single-crystal X-ray diffraction. In 1, substituted cobalt atoms share half occupancy sites with two W atoms on two asymmetric positions of opposite W3O13 trimers forming mono-substituted Keggin arsenotungstate. The Keggin clusters of two different arrays are alternately connected to generate unique wave-like chains in –A–B–A–B– ways via Co–O–W bridge. Compound 1 exhibits bifunctional electrocatalytic behavior for oxidation of ascorbic acid (AA) and reduction of hydrogen peroxide (H2O2), and good degradation ability for three typical dyes under UV light.
Synthesis, crystal structure and photo/electrocatalytic properties of a 1D chain based on monocobalt-substituted arsenotungstates
Creators: name: Wu, Chu
name: Lv, Jinghua
name: Yu, Kai
name: Zhang, He
name: Wang, Chunmei
name: Wang, Chunxiao
name: Zhou, Baibin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Computational Biology

description: A chain based on the Keggin polyoxoanions, (H2bipy)2(Hbipy)[AsW11CoO39]·H2O (bipy = 4,4′-bipyridine) (1), has been hydrothermally synthesized and characterized by elemental analysis, IR, UV, TG, and single-crystal X-ray diffraction. In 1, substituted cobalt atoms share half occupancy sites with two W atoms on two asymmetric positions of opposite W3O13 trimers forming mono-substituted Keggin arsenotungstate. The Keggin clusters of two different arrays are alternately connected to generate unique wave-like chains in –A–B–A–B– ways via Co–O–W bridge. Compound 1 exhibits bifunctional electrocatalytic behavior for oxidation of ascorbic acid (AA) and reduction of hydrogen peroxide (H2O2), and good degradation ability for three typical dyes under UV light.
Nitrous and nitric oxide emissions from a cornfield and managed grassland: 11 years of continuous measurement with manure and fertilizer applications, and land-use change
Creators: name: Mukumbuta, Ikabongo
name: Shimizu, Mariko
name: Jin, Tao
name: Nagatake, Arata
name: Hata, Hiroshi
name: Kondo, Seiji
name: Kawai, Masahito
name: Hatano, Ryusuke
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Changes in weather and management practices such as manure and fertilizer applications have a major effect on nitrous oxide (N2O) and nitric oxide (NO) emissions from soils. N2O and NO emissions exhibit high intra- and inter-annual fluctuations, which are also highly influenced by land-use change. In this study we investigated how land-use change between grassland and cornfield affects soil N2O and NO emissions using long-term field measurements in a mollic andosol soil in Southern Hokkaido, Japan. Soil N2O and NO emissions were monitored for 5 years in a 30-year old grassland (OG), which was then plowed and converted to a cornfield for 3 years and then converted back to grassland (new grassland, NG) for another 3 years. We established four treatment plots: control, without any nitrogen (N) input (CT plot); chemical fertilizer only (F plot); chemical fertilizer and manure (MF plot); and manure only (M plot). Changing land use from OG to cornfield increased annual N2O emissions by 6–7 times, while the change from cornfield to NG resulted in a 0.3–0.6 times reduction in annual N2O emissions. N2O emissions in the newly established grassland were 2–5 times higher than those in the 30-year old grassland. Soil mineral N (NO3− and NH4+) was higher in cornfield, followed by NG and lowest in OG, while water extractable organic carbon (WEOC) did not significantly change with changing land use but tended to be higher in OG and NG than in cornfield. The ratio of WEOC to soil NO3− was the most important explanatory variable for differences in N2O emissions as land use changed. High N input, surplus soil N, and precipitation and low soil pH led to increased N2O emissions. N2O emissions in fertilizer- and/or manure-amended plots were 3–4, 2–5 and 1.4–2 times higher than those in the control treatment in OG, cornfield and NG, respectively. NO emissions were largely influenced by soil mineral N and N addition, and showed less response to changing land use. There were high inter-annual variations in both NO and N2O emissions in all plots, including the control treatment, highlighting the need for long-term measurements when determining local emission rates.
Metabolism studies on hydroxygenkwanin and genkwanin in human liver microsomes by UHPLC-Q-TOF-MS
Creators: name: Yuan, Lin
name: Liang, Caijuan
name: Diao, Xinpeng
name: Cheng, Xiaoye
name: Liao, Man
name: Zhang, Lantong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Hydroxygenkwanin (HYGN) and genkwanin (GN) are major constituents of Genkwa Flos for the treatment of edema, ascites, cough, asthma and cancer. This is a report about the investigation of the metabolic fate of HYGN and GN in human liver microsomes and the recombinant UDP-glucuronosyltransferase (UGT) enzymes by using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). An on-line data acquisition method multiple mass defect filter (MMDF) combined with dynamic background subtraction (DBS) was developed to trace all probable metabolites. Based on this analytical strategy, three phase I metabolites and seven glucuronide conjugation metabolites of HYGN, seven phase I metabolites and 12 glucuronide conjugation metabolites of GN were identified in the incubation samples of human liver microsomes. The results indicated that demethylation, hydroxylation and o-glucuronidation were main metabolic pathways of HYGN and GN. The specific UGT enzymes responsible for HYGN and GN glucuronidation metabolites were identified using recombinant UGT enzymes. The results indicated that UGT1A1, UGT1A3, UGT1A9, UGT1A10 and UGT2B7 might play major roles in the glucuronidation reactions. Overall, this study may be useful for the investigation of metabolic mechanism of HYGN and GN, and it can provide reference and evidence for further experiments.
When Generative AI Meets Workplace Learning: Creating A Realistic & Motivating Learning Experience With A Generative PCA
Creators: name: Bucher, Andreas
name: Schenk, Birgit
name: Dolata, Mateusz
name: Schwabe, Gerhard
Publisher: name: arXiv
Year: 2024
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Workplace learning is used to train employees systematically, e.g., via e-learning or in 1:1 training. However, this is often deemed ineffective and costly. Whereas pure e-learning lacks the possibility of conversational exercise and personal contact, 1:1 training with human instructors involves a high level of personnel and organizational costs. Hence, pedagogical conversational agents (PCAs), based on generative AI, seem to compensate for the disadvantages of both forms. Following Action Design Research, this paper describes an organizational communication training with a Generative PCA (GenPCA). The evaluation shows promising results: the agent was perceived positively among employees and contributed to an improvement in self-determined learning. However, the integration of such agent comes not without limitations. We conclude with suggestions concerning the didactical methods, which are supported by a GenPCA, and possible improvements of such an agent for workplace learning.
TA'LIMDA "EFFECTIVE PRACTICAL PROJECT" (SAMARALI AMALIY LOYIHA) TEXNOLOGIYASINI QO'LLASH USULLARI
Creators: name: Isakov, Jasurbek
Publisher: name: Zenodo
Year: 2024

description: Mamlakatimizda amalga oshirilayotgan islohotlar, tadbiq etilayotgan yangiliklar, ta‘lim tarbiya-borasida yaratilayotgan shart-sharoitlar, xalqimizning yashash va mehnat qilish sharoitlarning yahshilanishi, umuman olganda erishilgan moddiy va ma‘naviy salohiyat erkinligi hamda bularning huquqiy asoslarining yaratilishi yoshlarni mustaqil ishlash va zaruratini ob’ektiv baholashga o‘rgatish yo‘nalishida o‘ziga xos vazifalar yuklaydi.
Synthesis, characterization, and properties of four lanthanide-based coordination polymers with mixed ligands of 4-((4′-carboxybenzyl)oxy)benzoic acid and oxalic acid
Creators: name: Chen, Wen-Xian
name: Zhou, Xiang
name: Gao, Yi-Fen
name: Liu, Qiu-Ping
name: Zhuang, Gui-Lin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: A series of lanthanide-based coordination polymers (Ln2(CBOB)2(OX)·H2O, where Ln = Gd (1), Eu (2), Pr (3), and Tb (4); CBOB = 4-[(4′-carboxybenzyl)oxy]benzoate; OX = oxalate), were obtained from the reaction of H2OX, H2CBOB, and Ln(NO3)3 with the metal salts. Single-crystal measurements show that both 1 and 2 feature unique 3-D structures with the [Ln(COO)n(C2O4)m] layers connected by CBOB ligands. Moreover, 1, 3, and 4 are antiferromagnetic and 2 and 4 display obvious luminescence emission peaks. Furthermore, quantum Monte Carlo (QMC) simulations and the experimental results reveal that the magnetic coupling parameters of adjacent Gd(III) ions in 1 are −0.026(2) and −0.0069(3) cm─1.
Synthesis, characterization, and properties of four lanthanide-based coordination polymers with mixed ligands of 4-((4′-carboxybenzyl)oxy)benzoic acid and oxalic acid
Creators: name: Chen, Wen-Xian
name: Zhou, Xiang
name: Gao, Yi-Fen
name: Liu, Qiu-Ping
name: Zhuang, Gui-Lin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: A series of lanthanide-based coordination polymers (Ln2(CBOB)2(OX)·H2O, where Ln = Gd (1), Eu (2), Pr (3) and Tb (4); CBOB = 4-[(4′-carboxybenzyl)oxy]benzoate; OX = oxalate) were obtained from the reaction of H2OX, H2CBOB and Ln(NO3)3 with the metal salts. Single-crystal measurements show that both 1 and 2 feature unique three-dimensional structures with the [Ln(COO)n(C2O4)m] layers connected by CBOB ligands. Moreover, 1, 3 and 4 are antiferromagnetic and 2 and 4 display obvious luminescence emission peaks. Furthermore, quantum Monte Carlo (QMC) simulations and the experimental results reveal that the magnetic coupling parameters of adjacent Gd(III) ions in 1 are −0.026(2) and −0.0069(3) cm─1.
Two new kaurane-type diterpenoids from Wedelia chinensis (Osbeck.) Merr
Creators: name: Cai, Cancan
name: Zhang, Yu
name: Yang, Dongqiong
name: Hao, Xiaojiang
name: Li, Shunlin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Two new kaurane-type diterpenoids, 3α-(angeloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (1) and 3α-(tigloyloxy)-17-hydroxy-ent-kaur-15-en-19-oic acid (2), along with 10 known compounds (3–12) were isolated from the whole plant of Wedelia chinensis (Osbeck.) Merr. Their structures were elucidated on the basis of extensive spectroscopic analyses (UV, IR, MS and NMR) and comparison with literature data. Compounds 3 and 4 showed moderate inhibitory activity against the Staphylococcus aureus subsp. aureus ATCC29213 with MIC50 19.35 and 18.31 μg/mL, respectively.
APPA Marking Sheet
Creators: name: Tate, Adam
Publisher: name: figshare
Year: 2022
Subjects: subject: 130303 Education Assessment and Evaluation
subject: FOS: Educational sciences
subject: 130103 Higher Education

description: This formative marking sheet is intended to be used by those reviewing the APPA submission of the Academic Professional Apprenticeship. This is not a final marking sheet but is designed to help keep track of whether the submission is demonstrating the KSVBs.
Copper-catalyzed tandem reaction of 2-haloanilines with thiocarbamoyl chloride: Synthesis of 2-aminobenzothiazoles
Creators: name: Chang, Cai-Zhu
name: Xu, Wan
name: Zeng, Meng-Tian
name: Liu, Min
name: Liu, Xing
name: Zhu, Hui
name: Dong, Zhi-Bing
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: A simple and efficient protocol for the synthesis of 2-aminobenzothiazoles by a ligand-free copper-catalyzed tandem reaction has been developed. In the presence of CuBr and t-BuOK, a variety of 2-haloanilines (halogen = Br, I) underwent the reaction with thiocarbamoyl chloride efficiently to afford the corresponding 2-aminobenzothiazoles in good yields (83–94%). The features of this method include good yield, cheap catalyst, mild reaction conditions, and broad substrate scope, which make the protocol practical and attractive in the preparation of some potential pharmaceutically active compounds.
Copper-Catalyzed Tandem Reaction of 2-Haloanilines with Thiocarbamoyl Chloride: Synthesis of 2-Aminobenzothiazoles
Creators: name: Chang, Cai-Zhu
name: Xu, Wan
name: Zeng, Meng-Tian
name: Liu, Min
name: Liu, Xing
name: Zhu, Hui
name: Dong, Zhi-Bing
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: A simple and efficient protocol for the synthesis of 2-aminobenzothiazoles by a ligand free copper-catalyzed tandem reaction has been developed. In the presence of CuBr and t-BuOK, a variety of 2-haloanilines (halogen = Br, I) underwent the reaction with thiocarbamoyl chloride efficiently to afford the corresponding 2-aminobenzothiazoles in good yields (83-94%). The features of this method includes good yield, cheap catalyst, mild reaction conditions and broad substrate scope, which make the protocol practical and attractive in the preparation of some potential pharmaceutically active compounds.