cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design and optimization of a shape memory alloy actuated pump with thermofluidic feedback
Creators: name: Pierce, Matthew D.
Publisher: name: University of Utah
Year: 2012
Subjects: Modeling
Pumps
Shape memory alloys
Artificial heart pumps

description: This thesis presents the design and optimization of a biologically inspired wet shape memory alloy (SMA) actuated pump that can provide thermal energy via fluidic  convection to actuate external wet SMA subsystems. Furthermore, the pump draws from its own fluidic output to assist in the actuation of its own internal SMA actuators. A thorough analysis of the previous wet SMA robotic heart is conducted by searching for opportunities for improvement. Methods of improving the pump's output-to-input ratio included modifying the pumping chambers, actuation cycle timing, implementing  electrical actuation, and continuously adding heat to the system.   Dynamic modeling was performed to provide a baseline indicator of what was to be expected during actual implementation and testing. The effects of changing various parameters were explored to determine optimal configurations. Key parameters affecting performance include mechanical advantage, actuator length, flow durations, and water temperature.  Implemented design changes and testing confirmed the modeling results. Continuous heating of the hot water within the pressurized accumulator greatly enhanced the pump's performance. Using only fluidic induced actuation, the output-to-input ratio peaked at 1.4. The pump reached an output-to-input ratio of 2.1 with the aid of electrical actuation. This is the first successful implementation of a self-sustaining thermofluidically powered SMA pump. Furthermore, unlike other SMA micropumps that typically output 1 mL/min or less, this pump is capable of a macroscale net output of 66 mL/min.  While the pump's output exceeds the required input, the power efficiency and power density of the pump do not compare to that of the human heart due to the amount of  power required to keep the hot water continuously heated. Viable options for improving efficiency and power density include minimizing pump mass, optimizing pumping chamber design, and reducing the amount of heat necessary to keep the hot water at an elevated temperature.
Sonnenfleckenzeichnung Nr. 23485.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Reduction-responsive PEtOz-SS-PCL micelle with tailored size to overcome blood–brain barrier and enhance doxorubicin antiglioma effect
Creators: name: Li, Yuling
name: Baiyang, Li
name: Leran, Bu
name: Zhen, Wang
name: Yandong, Xie
name: Baixiang, Du
name: Dandan, Zhu
name: Yufu, Zhu
name: Jun, Liang
name: Rutong, Yu
name: Hongmei, Liu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which were developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) and the micelle size could be regulated by designing the polymer structure. The DOX-loaded PEtOz-SS-PCL micelles had small size and rapid drug release in reductive intracellular environments. Biodistribution and in vivo imaging studies in C6 glioma mice tumor model showed that DOX loaded PEtOz-SS-PCL43 micelles with the smallest size had superior accumulation and fast drug release in tumor sites. In vivo antitumor activity demonstrated that DOX-loaded PEtOz-SS-PCL43 micelles improved antitumor efficacy in contrast to PEtOz-SS-PCL micelles with larger size toward the orthotopic C6-Luci cells-bearing mice. This study shows great potential in tailoring the micelle size and introducing the responsive bonds or compartment for intracellular drug delivery and release in glioma treatment by designing the architecture of the polymer.
Sonnenfleckenzeichnung Nr. 23406.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.07.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles
Creators: name: Zhong, Yinan
name: Meng, Fenghua
name: Deng, Chao
name: Mao, Xinliang
name: Zhong, Zhiyuan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: The chemotherapy of hematological cancers is challenged by its poor selectivity that leads to low therapeutic efficacy and pronounced adverse effects. Here, we report that doxorubicin encapsulated in lipoic acid-crosslinked hyaluronic acid nanoparticles (LACHA-DOX) mediate highly efficacious and targeted inhibition of human hematological cancers including LP-1 human multiple myeloma (MM) and AML-2 human acute myeloid leukemia xenografted in nude mice. LACHA-DOX had a size of ca. 183 nm and a DOX loading content of ca. 12.0 wt.%. MTT and flow cytometry assays showed that LACHA-DOX possessed a high targetability and antitumor activity toward CD44 receptor overexpressing LP-1 human MM cells and AML-2 human acute myeloid leukemia cells. The in vivo and ex vivo images revealed that LACHA-DOX achieved a significantly enhanced accumulation in LP-1 and AML-2 tumor xenografts. Notably, LACHA-DOX effectively suppressed LP-1 as well as AML-2 tumor growth and drastically increased mice survival rate as compared to control groups receiving free DOX or PBS. Histological analyses exhibited that LACHA-DOX caused little damage to the major organs like liver and heart. This study provides a proof-of-concept that lipoic acid-crosslinked hyaluronic acid nanoparticulate drugs may offer a more safe and effective treatment modality for CD44 positive hematological malignancies.
Nanoparticle-based delivery enhances anti-inflammatory effect of low molecular weight heparin in experimental ulcerative colitis
Creators: name: Yazeji, Tawfek
name: Moulari, Brice
name: Beduneau, Arnaud
name: Stein, Valentin
name: Dietrich, Dirk
name: Pellequer, Yann
name: Lamprecht, Alf
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Epithelial administration of low molecular weight heparin (LMWH) has proven its therapeutic efficiency in ulcerative colitis (UC) but still lacks of a sufficiently selective drug delivery system. Polymeric nanoparticles were used here not only to protect LMWH from intestinal degradation but also to provide targeted delivery to inflamed tissue in experimental colitis mice. LMWH was associated with polymethacrylate nanoparticles (NP) type A (PEMT-A) or type B (PEMT-B) of a size: 150 nm resulting in a maximum drug loading: 0.1 mg/mg. In a lipopolysaccharide-stimulated macrophages both, free LMWH and LMWH-NP have significantly reduced the cytokines secretion independently from cellular uptake. The in-vivo therapeutic efficiency was dose dependent as at low doses (100 IU/kg) only minor differences between free LMWH and LMWH-NP were found and the superiority of LMWH-NP became prominent with dose increase (500 IU/kg). Administration of LMWH-NP at 500 IU/kg has markedly improved the clinical activity as compared to LMWH while similarly pathophysiological indicators revealed increased therapeutic outcome in presence of NP compared to LMWH alone: Myeloperoxidase (Colitis control: 10 480 ± 5335, LMWH-PEMT-A NP: 1507 ± 2165, LMWH-PEMT-B NP: 382 ± 143, LMWH: 8549 ± 5021 units/g) and tumor necrosis factor: (Colitis control: 1636 ± 544, LMWH-PEMT-A NP: 511 ± 506, LMWH-PEMT-B NP: 435 ± 473, LMWH: 1110 ± 309 pg/g). Associating LMWH with NP is improving the anti-inflammatory efficiency of LMWH in-vivo by its protection against degradation in luminal environment and selective drug delivery. Such a combination holds promise for a highly specific therapy by its double selectivity towards the inflamed intestinal tissue. LMWH-PEMT NP have significantly improved the clinical activity in-vivo in comparison to free LMWH.
High temperature NOx sensing enabled by indium oxide thin films
Creators: name: Kannan, Srinivasan
Publisher: name: University of Utah
Year: 2012
Subjects: Gas sensors
High temperature
Indium oxide
NOx
Thin films

description: Generation of power using fossil fuel combustion invariably results in formation of undesirable gas species (NOx, SOx, CO, CO2, etc.) at high-temperatures which are harmful to the environment. Thus, there is a continual need to develop sensitive, responsive, stable, selective, robust and low-cost sensor systems and sensor materials for combustion monitoring. This work investigates the viability of microfabricated NOx  sensors based on sputtered indium oxide (In2O3) utilizing microhotplate structures. The material becomes resistive when exposed to oxidizing gases like NOx, with its conductivity dependent upon the temperature, partial pressure of the test gas and morphological structure. We believe this device would help increase efficiency and  decrease emissions through improved combustion process control, leading to a comparably economic and responsive sensor.
Second-tier testing for homocystinuria and for maple syrup urine disease
Creators: name: Garn, Joshua Val
Publisher: name: University of Utah
Year: 2012
Subjects: Alloisoleucine
Homocysteine
Homocystinuria
Maple syrup urine disease
MSUD
Second-tier test

description: One difficulty that many laboratories face with expanded newborn screening is a  high number of false positive test results. Modifying cutoffs has been used to reduce the false positive rate, but this is done at the expense of increasing the number of false negative test results. In this research, second-tier tests-defined as alternative methods used to test the same blood spot as the primary screening with no additional patient contact-were developed for homocystinruia and for maple syrup urine disease. The test for homocystinuria is specific for total  homocysteine, and the test for maple syrup urine disease is specific for hydroxyproline, allo-isoleucine, isoleucine, and leucine.  Parameters, such as sensitivity, specificity, precision, accuracy, reportable range,  carryover, reference interval and ion suppression were analyzed for each second-tier test.  Results indicate that both of these tests are acceptable for clinical testing, and that these  tests should be helpful in differentiating true positives from false positives. It is thus  recommended that these second-tier tests for homocystinuria and maple syrup urine  disease be implemented in the clinical setting.
Sonnenfleckenzeichnung Nr. 23467.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.09.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23338.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.05.1970, erstellt von Fritz Riesen.
Zusätzlich ist vermerkt: Sonnenturm
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23483.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.10.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Synergistic dual-modified liposome improves targeting and therapeutic efficacy of bone metastasis from breast cancer
Creators: name: Ke, Xianzhu
name: Lin, Wen
name: Li, Xiaokang
name: Wang, Hailiang
name: Xiao, Xin
name: Guo, Zheng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Breast cancer frequently metastasizes to bone, where it leads to poor clinical prognosis. Due to the peculiarity of the bone microstructure, the uptake of drugs often happens at non-targeted sites, which produces a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both an octapeptide with eight repeating sequences of aspartate (Asp8) and folate to create a more selective and efficient drug delivery system to target cancer cells in bone tissue. Asp8 and folate were conjugated to the distal ends of DSPE-PEG2000-maleimide and DSPE-PEG2000-amine to create DSPE-PEG2000-Asp8 and DSPE-PEG2000-Folate, respectively, which were incorporated onto the surface of a doxorubicin (DOX)-loaded liposomes (A/F-LS). Asp8, similar to the hydroxyapatite-binding domains of osteopontin and osteocalcin, has been used as bone-targeting moieties for exclusive delivery of drugs to bone. The folate moiety binds selectively to folate receptor-positive tumors. The dual-targeting effects were evaluated by both in vitro and in vivo experiments. By taking advantages of dual-targeting drug delivery, the dual-modified liposomal drug system could relieve pain and improve survival. Inspired by its enhanced therapeutic efficacy and low toxicity, DOX-loaded A/F-LS could serve as an effective drug system for targeted therapy of bone metastases.
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles
Creators: name: Kadari, Amrita
name: Gudem, Sagarika
name: Kulhari, Hitesh
name: Bhandi, Murali Mohan
name: Borkar, Roshan M.
name: Kolapalli, Venkata Ramana Murthy
name: Sistla, Ramakrishna
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid nanoparticles) as a complex of HPβCD (hydroxyl propyl beta cyclodextrin) and to assess its anti-cancer activity against breast cancer cells. FST-HPβCD inclusion complex (FHIC) was prepared and the supramolecular complex formation was characterized by FTIR, DSC, PXRD and 1H NMR. FHIC encapsulated PLGA nanoparticles (FHIC-PNP) were prepared and were studied for in vitro anticancer activity, cellular uptake, apoptosis and reactive oxygen species generation in MCF-7 human breast cancer cells. Comparative bioavailability of FST was determined after oral administration in C57BL6 mice as pure FST and FHIC-PNP. The results revealed that FHIC-PNP not only enhanced the anti-cancer activity and apoptosis of FST against MCF-7 cells but also improved its oral bioavailability, as demonstrated by increased peak plasma concentration and total drug absorbed.
Relationship between duration of bedrest and occurrence of deep vein thrombosis in patients having undergone total hip replacement surgery
Creators: name: Westphal, Helga
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Nursing
subject: FOS: Health sciences

description: This ex post facto study examined the medical records of 100 patients who underwent total hip replacement surgery (THR) in order to ascertain the relationship between duration of bedrest and incidence of deep vein thrombosis (DVT) in a Salt Lake City hospital.  No case of DVT were documented in the charts reviewed.  Results indicated that ambulation following three day of bedrest after THR surgery appears to be sufficient to avoid complications of venous emboli.  However, limitations such as retrospective design and use of clinical signs to detect DVT, limited the validity of the results.  Five patients presented simultaneous risk facts of DVT and complications that suggested the need for a more objective test definitively rule out the disorder.  The use of more sophisticated technique to confirm the efficacy of early ambulation and anticoaqulant therapy in the prevention of DVT in THR surgery patients is recommended.  Nurses are urged to develop awareness of the risk factors and to maintain suspicion in the face of clinical sighs for DVT.
Sonnenfleckenzeichnung Nr. 23348.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: An examination of improvements in OLED quality and fabrication
Creators: name: Passannante, Anthony
Publisher: name: URMSE
Year: 2020

description: This paper will discuss recent advancements in the fabrication and applications of OLED. As it stands now, OLED has revealed itself as having highly desirable qualities, applicable in a broad range of fields, from cutting edge computer technology, to improvements in medical diagnosis. Despite these advantages, OLED still lacks greatly in efficiency and reliability in comparison to other similar electro-optical materials systems such as LCD. This paper will cover the disadvantages of OLED as well as recent attempts and breakthroughs made in order to improve upon and negate these disadvantages. In particular, recent publications detailing methods to reduce the cost of fabrication of OLED through the novel use metal oxides, improvements in reliability through different surface treatments, and a new method of water protection are examined.
Aberrant RNA splicing of the phytic acid synthesis gene inositol-1,3,4 trisphosphate 5/6-kinase in a low phytic acid soybean line
Creators: name: Qin, Dong
name: Nishida, Sho
name: Tominaga, Rumi
name: Ueda, Akihiro
name: Raboy, Victor
name: Saneoka, Hirofumi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Most phosphorus is stored as phytic acid in plant seed, although it is considered an anti-nutrient compound that reduces the bioavailability of minerals in monogastric animals. Low-phytic acid (LP) crops improve mineral bioavailability in monogastric animals, which can decrease environmental pollution due to phosphorus. Recently, we reported a newly developed LP soybean line by crossing the LP line CX1834 and Japanese normal phytic acid cultivar Natto-kotsubu (Natto), which showed superior traits in seedling emergence, growth, and yield compared with CX1834. The molecular mechanism underlying the LP trait in the LP line remains unclear. The LP line was used for a de novo RNA-Seq analysis, and we illustrated the aberrant RNA splicing of the phytic acid synthase gene inositol-1,3,4 trisphosphate 5/6-kinase 3 (GmITPK3) in the LP line. The expression level of phytic acid biosynthesis-related genes and inositol phosphate isomer concentrations were investigated. A de novo RNA-Seq analysis revealed that the intron retention (IR) transcript of GmITPK3 is highly expressed in the leaves of the LP line. Although expressed in both, the relative abundances of multiple IR transcripts were significantly higher in the LP line than that in the Natto cultivar. The IR transcripts of GmITPK3 encoding truncated proteins were missing an essential domain for their activity, while one possibly contained an abnormal ligand binding site. The relative abundance of IR transcripts was 1.9- to 5.4-times higher in the LP line than that in the Natto cultivar during seed development; accordingly, the production of phytic acid and its precursors in the developing seeds was lower in the LP line than that in the Natto cultivar. No mutation was detected at the exon–intron junction, where a splicing error occurs in GmITPK3 of the LP line, implying that a splicing error is attributed to unknown splicing factor genes involved in the splicing regulation of GmITPK3. Our results provide insights into the possible involvement of splicing errors in GmITPK3 for the trait of low phytic acid production in the LP line.
Relationship between soil phosphorus dynamics and low-phosphorus responses at specific root locations of white lupine
Creators: name: Kan, Ayane
name: Maruyama, Hayato
name: Aoyama, Nao
name: Wasaki, Jun
name: Tateishi, Yoshiko
name: Watanabe, Toshihiro
name: Shinano, Takuro
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Phosphorus (P) is an essential element for crop production; however, availability tends to be low due to slow diffusion and high fixation in soils. To cope with phosphate deficiency, white lupines (Lupinus albus L.) form unique root structures called cluster roots. The objective of this study was to elucidate detailed spatial differences of the mechanisms under low-P condition in the root system using rhizoboxes. We cultivated plants in rhizoboxes with P-deficient soil for 33 days. We then harvested roots and the adjacent soil from 128 compartments by dividing 2 × 2 cm squares in the rhizoboxes. We investigated relative expression levels of several genes that encode proteins assumed to be involved in P solubilization or translocation. Additionally, we analyzed fractionated P, soluble metal cations (Fe, Al, and Mn), and enzyme activities in the soil of each compartment. We observed a significant positive correlation between one of the MATE (multidrug and toxic compound extrusion/detoxification) genes, LaMATE6, and soluble metal cations, suggesting the secretion of citric acid into the rhizosphere via MATE proteins increased soluble metal cation concentrations. Furthermore, we demonstrated that roots in the same developmental stages were likely to have different influences on the mobilization of fractionated P in the rhizosphere soil. Our findings highlight the importance of investigating the relationship between soil chemical properties and root functions at a high spatial resolution to elucidate the detailed mechanisms of P mobilization by plants.
Sonnenfleckenzeichnung Nr. 23387.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Heterogenity of fiscal year-end choice: exploring influences and effects by examining fiscal year-end changes
Creators: name: Solheim, Perry Warren
Publisher: name: University of Utah
Year: 2012
Subjects: Fiscal-year
Heterogeneity

description: In my dissertation I explore motivations and effects of the accounting choice of fiscal year-end (FYE). I demonstrate that the choice is neither static nor uniform. A nontrivial number of firms initially choose an FYE that differs from that of the majority of their industry. The majority and nonmajority firms differ along the dimensions of performance, strategy, administrative costs and information environment. I further explore whether these differences are evident in firms that changed their FYE. I find some evidence that firms may select an initial FYE or subsequently change their FYE in  an effort to influence their subindustry group membership. I find evidence that firms may make their FYE choice to take advantage of potential savings in administrative costs. I find evidence that the choice may be influenced by information environment factors.
Sonnenfleckenzeichnung Nr. 23537.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.12.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: Advances in lead-free perovskite phototransistors
Creators: name: Huynh, Vivian
Publisher: name: URMSE
Year: 2020

description: Perovskites have been a popular research focus in the solar cell industry for the previous two decades for its high efficiency and low cost. Recently, the interest in perovskites have expanded into other electrical devices that include phototransistors. With increasing environmental concern regarding perovskite toxicity, lead-free perovskites have become a large focus in research. This review highlights recent research of different lead-free perovskites and gives insight into their effectiveness as phototransistors
N-Butyl-2-cyanoacrylate-based injectable and in situ-forming implants for efficient intratumoral chemotherapy
Creators: name: Wu, Yanpu
name: Wang, Luming
name: Zhang, Kaili
name: Zhou, Lixiao
name: Zhang, Xiaobing
name: Jiang, Xuecheng
name: Zhu, Chenggang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: The local delivery of chemotherapeutic drugs to tumor sites is an effective approach for achieving therapeutic drug concentrations in solid tumors. Injectable implants with the ability to form in situ represent one of the most promising technologies for intratumoral chemotherapy. However, many issues must be resolved before these implants can be applied in clinical practice. Herein, we report a novel injectable in situ-forming implant system composed of n-butyl-2-cyanoacrylate (NBCA) and ethyl oleate, and the sol–gel phase transition is activated by anions in body fluids or blood. This newly developed injectable NBCA ethyl oleate implant (INEI) is biodegradable, biocompatible, and non-toxic. INEI solidifies in several seconds after exposure to body fluids or blood, and the implant’s in vivo degradation time can be controlled. In addition, the pore sizes formed by the polymerization of NBCA can be decreased by increasing the NBCA concentration in the implants. Therefore, the drug retention/release time can be adjusted from a few weeks to several months by changing the concentration of NBCA in the implant formulation. Anti-tumor experiments in animal models showed that the average growth inhibition rate of xenografted human breast cancer cells by the paclitaxel-loaded INEI (40% NBCA) was 80%, and they also indicated that tumors in some of the mice were completely eliminated by just a single dosage injection. For the epirubicin-loaded INEI (50% NBCA), the average growth inhibition rate of xenografted human liver cancer cells was 58%. Thus, the chemotherapeutic drug-loaded INEIs exhibited excellent therapeutic efficacy for local chemotherapy.
Hydrophobic binding peptide-conjugated hybrid lipid-mesoporous silica nanoparticles for effective chemo-photothermal therapy of pancreatic cancer
Creators: name: Thapa, Raj Kumar
name: Nguyen, Hanh Thuy
name: Gautam, Milan
name: Shrestha, Aarajana
name: Lee, Eung Seok
name: Ku, Sae Kwang
name: Choi, Han-Gon
name: Yong, Chul Soon
name: Kim, Jong Oh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Nanoparticle-based drug delivery systems are designed to reach tumor sites based on their enhanced permeation and retention effects. However, a lack of interaction of these nanoparticles with cancer cells might lead to reduced uptake in the tumors, which might compromise the therapeutic efficacy of the system. Therefore, we developed bortezomib and IR-820-loaded hybrid-lipid mesoporous silica nanoparticles conjugated with the hydrophobic-binding peptide, cyclosporine A (CsA), and referred to them as CLMSN/BIR. Upon reaching the tumor site, CsA interacts hydrophobically with the cancer cell membranes to allow effective uptake of the nanoparticles. Nanoparticles ∼160 nm in size were prepared and the stability of IR-820 significantly improved. High cellular uptake of the nanoparticles was evident with pronounced apoptotic effects in PANC-1 and MIA PaCa-2 cells that were mediated by the chemotherapeutic effect of bortezomib and the photothermal and reactive oxygen species generation effects of IR-820. An in vivo biodistribution study indicated there was high accumulation in the tumor with an enhanced photothermal effect in PANC-1 xenograft mouse tumors. Furthermore, enhanced antitumor effects in PANC-1 xenograft tumors were observed with minimal toxicity induction in the organs of mice. Cumulatively, these results indicated the promising effects of CLMSN/BIR for effective chemo-phototherapy of pancreatic cancers.
Structural studies on the psi-conotoxins and the secondary metabolites of a marine tunicate
Creators: name: Van Wagoner, Ryan Michael
Publisher: name: University of Utah
Year: 2012
Subjects: Deoxyribonucleic Acid
Tetrahydropentoxoyline

description: Each project described in this dissertation explores the three-dimensional structure of the psi-conotoxins, the structural and neurotoxicological impact of each loop region of the psi-conotoxins, or the chemical structure of metabolites isolated from a marine ascidian. One of the characteristic features of the conotoxins is a high density of disulfide bridges in each peptide. The conformational properties of the disulfide bridges in previously determined conotoxin structures are reviewed in the first chapter. The second chapter describes the use of selective 13C-labeling of cysteine residues as a means of resolving resonance overlap problems in NMR for conotoxins through the use of 13C-filtering and 13C-editing. This chapter also describes the determination of a revised structure for psi-conotoxin PIIIE. Interproton distance restraints were derived from NOESY correlations through relaxation matrix calculations. A new set of structures were produced that were more precise, less strained, and better correlated with the experimental data. The revised structures differed from the original structures in the distribution of positive charges. The third chapter describes the structure determination of psi-conotoxin PIIIF using the same methodologies applied to psi-PIIIE. The structure of psi-PIIIF is very similar to that of psi-PIIIE. The two toxins differ in the degree of convergence of the chain termini, the distribution of polarity on the peptide surfaces, and in the degree of conformational freedom of the disulfide bridges. The fourth and fifth chapters explore the structure and activity of a series of chimeric mutant psi-conotoxins incorporating loop regions of both psi-PIIE and psi-PIIIF. The second loop region of the psi-conotoxins is the prime determinant of the degree of conformational freedom in the disulfide bridges. The binding of the psi-conotoxins and chimeric mutants to nAChR from the electric organ of Torpedo californica expressed on Xenopus oocytes was explored through electrophysiology. The third loop region had the largest impact on inhibitory potency. The first loop also affected potency. The sixth chapter describes studies exploring the secondary metabolites produced by a previously undescribed Eudistoma> species of ascidian. A series of guanidinium-containing beta-carbolines were discovered. Other metabolites isolated include a polyhydroxylated ?-carboline, a brominated tyramine, and a methylated isoxanthopterin.
Sonnenfleckenzeichnung Nr. 23528.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.12.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Doing family: communicating memories of the Japanese American incarceration
Creators: name: Kashiwase, Laura M.
Publisher: name: University of Utah
Year: 2014
Subjects: Identity
Incarceration
Japanese American
Memory
Oral history
World War II

description: While official government photographs from the Incarceration of Japanese Americans during World War II has received scholarly attention, private photographs from the Incarceration are also valuable to the reconstruction of personal Camp memories. Using my family's photographs, I conducted oral history interviews with 5 family members who were incarcerated at Topaz or Amache Camps. My thesis employs a performance studies lens in order to better understand the relationship between memory, identity, agency, and photographs. My approach recognizes that memory, identity, and agency are complex ongoing processes, which are informed by, and inform, one another. In all, through purposeful acts of forgetting in the oral history interviews, my relatives were able to (re)conceive their Camp experiences in ways that fit their present needs. For example, in remembering to forget, the Nisei are able to construct a memory of the Camp experience that supports their identities as Japanese Americans by reinforcing their identity as an American through the depoliticization of Camp memories. Additionally, in order to better make sense of the relationship between photographs and the memory construction process, I provided a binder of family photographs from the Camps for the interviewees to view. My analysis suggests that photographs in the oral history performance are used as a prop that allows for acts of both remembering and forgetting while embracing the fragmented nature of memories. Overall, this study reveals the relationship between identity and memory with implications on how this interaction allows us to remember, forget, or remain silent. In my attempt to understand how my relatives' constructed memories of their Incarceration, I was able to reflect on my own experiences as a Japanese Chinese American. To this end, memories are not only about what is remembered, they are also about how what is forgotten and what is remembered reinforce and are reinforced by identity.
Sonnenfleckenzeichnung Nr. 23440.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Effects of angled stitch reinforcement on foam core sandwich structures
Creators: name: Sok, Thien
Publisher: name: University of Utah
Year: 2012
Subjects: Composite
Creep
Foam
Reinforcement
Sandwich
Angled stitch

description: The mechanical effects of varying stitch angles in stitched sandwich structures were investigated. A repeatable fabrication method was developed for stitching Kevlar yarn through sandwich panels of polyurethane foam and dry woven carbon fiber  facesheets. Unstitched, 30o, 45o, 60o, and 90o stitch orientations, measured from the horizontal, were used throughout the study. Mechanical tests of flatwise tension, flatwise compression, and core shear were performed to observe the stiffness and strength effects  of the different stitch configurations. With only a easured areal density increase of 2-7%, stitches oriented at 90o were found to nearly double out-of-plane tensile stiffness and strength while compressive stiffness and strength increased only modestly.
Steroid regulation of programmed cell death during Drosophila metamorphosis
Creators: name: Jiang, Changan
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Steroids

description: During Drosophila metamorphosis, pulses of the steroid hormone ecdysone trigger the histolysis of larval tissues in a stage-specific manner, but the mechanism of this developmental response remains unclear. In these studies, we show that histolysis of both the larval midgut and salivary glands is accompanied by increased nuclei permeability, DNA fragmentation and caspase activation, indicative of apoptotic cell death. Two Drosophila cell death activators, reaper (rpr) and head involution defective (hid), are induced by ecdysone in the larval midgut and salivary glands immediately preceding their histolysis, suggesting that the larval tissues are destroyed through the activation of the same apoptotic pathway that is employed during Drosophila embryogenesis. In addition, the cell death inhibitor diap2 is transiently induced in mid-prepupal salivary glands, but repressed in late prepupae, as rpr and hid are induced. These expression patterns suggest that ecdysone directs salivary gland cell death by simultaneously repressing diap2 and inducing  rpr and hid. This hypothesis is supported by the results of our molecular genetic analysis which indicates that ecdysone triggers the switch in death gene expression through the ecdysone receptor and ecdysone-regulated transcription factors. Two ecdysone-inducible orphan nuclear receptors, E75A and E75B, are sufficient to repress diap2. In addition, ecdysone induces the Broad-Complex (BR-C) and E74A, which function together with the ecdysone receptor to induce rpr and hid. Our preliminary studies also show that two stress-activated transcription factors, AP-1 and NF-kappa-B, may function as stage-specific activators of rpr and hid in larval salivary glands. Based on these studies, we propose that the ecdysone receptor, ecdysone-induced transcription factors and the stress-response pathways cooperate to precisely regulate larval salivary gland cell death.
title: Material characterization in the identification of unknowns
Creators: name: Song, Henry
Publisher: name: URMSE
Year: 2020

description: Materials characterization methods are widely used in many fields, such as in determining material properties when selecting materials to be used for a wide variety of purposes, such as building construction; aircrafts; and machines; or being used in application such as failure analysis to determine how a part failed and how it can be prevented in the future. Another application of materials characterization techniques that is less mentioned, however, is their use in identifying the identity and history of a material. This review seeks to explore this application of characterization methods, describing both how the methods are used, and the results obtained, with special focus on optical microscopy, used to examine the surfaces of structures, and various spectroscopies, used in examining various properties such as composition, crystal structure, etc.