cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Minimum Hellinger Distance Estimation of AFT Models with Right-Censored Data
Creators: name: Huang, Yifu
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Education--Mathematics

description: Accelerated Failure Time (AFT) models are popular models used in survival analysis. AFT models are also an important alternative to the Cox Proportional Hazards (PH) models as they have better interpretability and link the survival time (usually on the log scale) directly to the covariates. The unknown coefficient parameters in AFT models are often estimated by the maximum likelihood estimator (MLE). However, the performance of MLE would be severely affected by the presence of outliers. In this thesis, we proposed two estimators to estimate the parametric AFT models based on minimum Hellinger distance estimation (MHDE). A simulation study and a real data analysis were conducted to examine the performance of the proposed estimators under various scenarios for censoring rate and presence of outliers. Our numerical results demonstrated the excellent robustness of the proposed estimators which also retain good efficiency for many cases.
Engagement from the Community Perspective: Understanding the Role Community Associations Play in Planning and Development in Calgary
Creators: name: Poschmann, Rebecca Anne
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Community Engagement
subject: Public Participation
subject: Community Associations
subject: Redevelopment
subject: Urban Planning
subject: Development
subject: Volunteer Organizations
subject: Urban and Regional Planning
subject: FOS: Social and economic geography

description: Change, through urban planning, is inevitable and necessary because it responds to growth, community needs, and the ever-changing economy. To steer change, planning projects benefit when effective community engagement programs are applied. Community associations have long been advocating on behalf of their communities, however the level of influence they have on decision-making is unclear in part to their level of authority being unclear. Interviews helped answer two connected research questions. The first question focuses on community associations by asking: What is the role community associations play when an urban planning project is proposed within their community? The second question focuses on authority: Should the level of engagement vary based on the level of impact the planning project may have on the community, as identified by the community association? Community voices from Calgary, Alberta, Canada, shared their experiences with engagement on planning and development projects. Three overarching themes emerged through inductive and deductive analysis of the interview data: constraints community associations experience with community engagement; opportunities of community engagement; and frustrations felt by community associations in regard to community engagement opportunities. The study results suggest that community associations are limited to instill change through engagement, despite their perceived role. Based on the research data, three recommendations to support community associations are proposed: extending timelines and enforcing engagement on complex planning projects, redefining the role of a community association, and developing community engagement profiles. The impact of these recommendations presents three opportunities to evolve community engagement in planning at a community level.
The peculiar isolated neutron star in the Carina Nebula - Deep XMM-Newton and ESO-VLT observations of 2XMM J104608.7-594306
Creators: name: Pires, Adriana Mancini
name: Motch, Christian
name: Turolla, Roberto
name: Schwope, Axel
name: Pilia, Maura
name: Treves, Aldo
name: Popov, Sergei B.
name: Janot-Pacheco, Eduardo
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: While fewer in number than the dominant rotation-powered radio pulsar population, peculiar classes of isolated neutron stars (INSs) -- which include magnetars, the ROSAT-discovered "Magnificent Seven" (M7), rotating radio transients (RRATs), and central compact objects in supernova remnants (CCOs) -- represent a key element in understanding the neutron star phenomenology. We report the results of an observational campaign to study the properties of the source 2XMM J104608.7-594306. Its evolutionary state is investigated by means of deep dedicated observations obtained with XMM-Newton, the ESO Very Large Telescope, as well as publicly available gamma-ray data from the Fermi and AGILE missions. The observations confirm previous expectations and reveal a unique type of object. The source, which is likely within the Carina Nebula, has a soft spectrum with absorption features and no magnetospheric emission. The optical counterpart is fainter than V=27 and no gamma-ray emission is significantly detected. Very interestingly, while these characteristics are remarkably similar to those of the M7 or the only RRAT so far detected in X-rays, which all have spin periods of a few seconds, we found intriguing evidence of very rapid rotation, P=18.6 ms. We interpret these new results in the light of the observed properties of the currently known neutron star population, in particular those of standard rotation-powered pulsars, recycled objects, and CCOs. We find that none of these scenarios can satisfactorily explain the collective properties of 2XMM J104608.7-594306, although it may be related to the still poorly known class of Galactic anti-magnetars. Future XMM-Newton data, granted for the next cycle of observations (AO11), will help us to improve our current observational interpretation of the source, enabling us to significantly constrain the rate of pulsar spin down.
description: 17 pages, 8 figures, accepted for publication in A&A (revised version after language editing; results unchanged)
Mechanics and Energetics of Force Production in Muscle
Creators: name: Van Der Zee, Tim Jonathan
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: muscle energetics
subject: SERCA
subject: calcium transport
subject: biomechanics
subject: metabolic cost
subject: cross-bridge model
subject: musculoskeletal modelling
subject: muscle force production
subject: rate of muscle force development
subject: Engineering--Biomedical
subject: Physiology
subject: FOS: Biological sciences

description: The mechanics and energetics of skeletal muscle force production are important for many movements, including locomotion. But they have been characterized primarily for steady conditions such as constant shortening velocity and fixed muscle length, rather than dynamic or cyclic conditions that resemble daily movements. Although musculoskeletal models are intended to predict how muscles behave during movement, there have been few quantitative experiments to inform such models. In this thesis, I experimentally examine muscle mechanics and energetics for cyclic conditions, and then apply those data to develop a new computational model of muscle. The model reproduces activation and force development dynamics observed experimentally, is more mechanistic than current Hill-type models, and better matches energy expenditure for cyclic conditions. A simple summary of these effects is that muscle behaves like a low-pass filter with respect to excitatory input. A filter predicts a sharp increase in energetic cost with faster cyclic conditions, in agreement with empirical data (Chapter 2). To facilitate quantification of muscle mechanics in vivo, I developed an algorithm to track muscle fascicles in ultrasound images, named ‘TimTrack’ (Chapter 3). Much of the energetic cost of cyclic force production was not explained by traditional measures of work or force, but by rate of force development (termed ‘force-rate’). To expand on the low-pass filter, I proposed a model that combines muscle dynamics with steady relations and series elasticity. Unlike existing models, the proposed model predicts muscle force development across a broad range of conditions in a self-consistent manner (Chapter 4). An essential aspect is a set of dynamics intermediate to calcium activation and muscle cross-bridges, here termed force facilitation. These dynamics help explain the energetic cost of both steady and cyclic muscle contractions, in qualitative agreement with the simple low-pass filter (Chapter 5). Model simulations suggest that most of the force-rate cost is due to increased calcium transport at higher muscle excitation levels. The experiments and computational modeling presented here demonstrate energetic costs not previously identified or modeled and have potential to improve understanding of how muscles contribute to daily movements.
Additional file 1 of Canadian Women in Otolaryngology—Head and Neck Surgery part 1: the relationship of gender identity to career trajectory and experiences of harassment
Creators: name: Ioanidis, Khrystyna
name: Naismith, Kendra
name: Dzioba, Agnieszka
name: MacNeil, S. Danielle
name: Paradis, Josée
name: Nayan, Smriti
name: Strychowsky, Julie E.
name: Graham, M. Elise
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Survey material distributed to Canadian Society of Otolaryngology—Head and Neck Surgery membership.
Sunius cordiformis ASSING 2002
Creators: name: Assing, Volker
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Sunius
Sunius cordiformis

description: Sunius cordiformis ASSING, 2002 Material examined: China: 1 ex., Sichuan, 24 km SE Lucheng ["Tatsien"], "Wa-Su-Kou", 29°55', 102°13'E [" 29°30'N, 103°00'E "], Tung river, 1600 m, 5.X.1935, leg. Schäfer (NHMW); 1 ex., Yunnan, Lijiang, Hutiaoxia, stream bank litter, 14.IV.2003, leg. de Rougemont (cRou). The species was previously known only from the Chinese provinces Beijing and Shaanxi (ASSING 2002). It is here reported from Sichuan and Yunnan for the first time.
description: Published as part of Assing, Volker, 2008, Four new species and additional records of Palaearctic Sunius, with two new synonymies (Coleoptera: Staphylinidae: Paederinae), pp. 455-470 in Beiträge Zur Entomologie = Contributions to Entomology 58 (2) on page 469, DOI: 10.21248/contrib.entomol.58.2.455-470, http://zenodo.org/record/5364618
description: {"references": ["ASSING, V. 2002: New species of Sunius CURTIS from China and Iran (Coleoptera: Staphylinidae, Paederinae). - Linzer biologische Beitrage 34: 289 - 296."]}
A Multilevel Meta-Analytical Review of Job-Organizational Attraction during Recruitment
Creators: name: Davie, Christopher Aaron
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Recruitment
subject: Attraction
subject: Meta-analysis
subject: Employee recruitment
subject: Job applicants
subject: Systematic review
subject: Organizational behavior
subject: Psychological aspects
subject: Correlation analysis
subject: Career choice
subject: Studies
subject: Quantitative analysis
subject: Personnel psychology
subject: Personnel recruitment
subject: Occupational choice
subject: Occupational psychology
subject: Organization culture
subject: Person-environment fit
subject: Person-organization fit
subject: Job search
subject: Job choice
subject: Job application
subject: Human
subject: Human resources
subject: Employee selection
subject: Corporate culture
subject: Psychology--Industrial

description: Modern-day recruitment activities have become a critical activity for organizations as they participate in the “war for talent” (Michaels, Handfield-Jones, & Axelrod, 2001). We used multilevel meta-analytic models to examine the relationship between eight categories of recruitment predictors and the job-organization attraction of applicants during the first stage of recruitment. Based on 318 independent studies, 330 independent samples, 1243 correlation coefficients, and a total of 109,057 participants, we identified the strength of the relationships of job characteristics, organization characteristics, recruiter characteristics, perceptions of the recruitment process, perceived fit, perceived alternatives, hiring expectancy, and recruitment information source. Perceived fit was the strongest predictor category, with the strongest individual predictor being person-job fit. Applicant-type, applicant gender, applicant age, applicant race, and year of publication were shown to moderate the relationships between recruitment predictors and job-organization attraction. Lab-samples were shown to be different from field samples when applicants were considering advancement opportunities, person-job fit, perceived hiring expectancy, and whether the recruitment process was job-related. Online samples were shown to be different from field samples when applicants were considering compensation and advancement, advancement opportunities, and whether the recruitment process was job-related. Sample-specific characteristics (i.e., age, gender, and race) were shown to moderate many of the predictor-criterion relationships. Year of publication was shown to moderate many relationships, most showing that present-day applicants are placing increased importance on corporate social responsibility. These findings' theoretical and practical implications are discussed with suggestions for future research.
Data assimilation in slow-fast systems using homogenized climate models
Creators: name: Mitchell, Lewis
name: Gottwald, Georg A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Chaotic Dynamics (nlin.CD)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences
subject: J.2

description: A deterministic multiscale toy model is studied in which a chaotic fast subsystem triggers rare transitions between slow regimes, akin to weather or climate regimes. Using homogenization techniques, a reduced stochastic parametrization model is derived for the slow dynamics. The reliability of this reduced climate model in reproducing the statistics of the slow dynamics of the full deterministic model for finite values of the time scale separation is numerically established. The statistics however is sensitive to uncertainties in the parameters of the stochastic model. It is investigated whether the stochastic climate model can be beneficial as a forecast model in an ensemble data assimilation setting, in particular in the realistic setting when observations are only available for the slow variables. The main result is that reduced stochastic models can indeed improve the analysis skill, when used as forecast models instead of the perfect full deterministic model. The stochastic climate model is far superior at detecting transitions between regimes. The observation intervals for which skill improvement can be obtained are related to the characteristic time scales involved. The reason why stochastic climate models are capable of producing superior skill in an ensemble setting is due to the finite ensemble size; ensembles obtained from the perfect deterministic forecast model lacks sufficient spread even for moderate ensemble sizes. Stochastic climate models provide a natural way to provide sufficient ensemble spread to detect transitions between regimes. This is corroborated with numerical simulations. The conclusion is that stochastic parametrizations are attractive for data assimilation despite their sensitivity to uncertainties in the parameters.
description: Accepted for publication in Journal of the Atmospheric Sciences
Frequency and Predictors of Manual Use and Evidence-Based Psychological Interventions Among Clinicians Treating Eating Disorders in British Columbia
Creators: name: Bajaj, Deepika
Publisher: name: Arts
Year: 2023
Subjects: subject: eating disorders
subject: evidence-based psychological interventions
subject: protocol-based approaches
subject: empirically supported treatments
subject: therapist drift
subject: Psychology--Clinical

description: Several evidence-based psychological interventions (EBPIs) exist for eating disorders (EDs). Yet, these interventions and manuals are underutilised in clinical practice. This study described psychological interventions British Columbia (BC) clinicians used to treat EDs and examined factors associated with manual and EBPI use. Participants were recruited from a list of 1,530 potential participants created for this study by identifying clinicians listing online that they treat EDs, as well as through social media advertisement and snowball recruitment. One hundred and twenty-six community counsellors and psychotherapists providing psychological intervention to individuals with EDs across BC described their ED clients, psychological interventions used, and their training. To examine predictors of EBPI and manual use, these participants provided demographic information and completed measures of affect, intolerance of uncertainty, and attitudes toward treatment manuals. Overall, 8% of respondents indicated that they often used manuals in their clinical work. Use of EBPIs by clinicians for treatment of anorexia nervosa, bulimia nervosa, and binge eating disorder ranged from 2%-15%. Logistic regression analyses identified two factors associated with manual use included: negative attitudes toward manuals were associated with infrequent use of manuals, whereas positive attitudes toward manuals were associated with increased likelihood of manual use. Unexpectedly, logistic regression analyses did not identify any factors that significantly predicted of EBPI use. The low uptake of EBPIs for the treatment of EDs suggests that ED client may be receiving suboptimal care, highlighting the need for future work to address barriers to EBPI use. Future research should explore beyond clinician characteristics and investigate how external and intervention factors may impact the adoption and implementation of EBPIs and manuals in ED treatment.
Link between serotonin neuron specific tau pathology and emotional dysregulation
Creators: name: Khan, Nazmus Sakib
Publisher: name: Arts
Year: 2023
Subjects: subject: Alzheimer's Disease
subject: Neurodegeneratie
subject: Tau
subject: Serotonin
subject: Dorsal Raphe Nucleus
subject: Neuroscience
subject: Psychology--Experimental

description: At present, half a million Canadians are suffering from dementia and dementia related disorders costing approximately $11 billion annually and putting additional strain on a struggling health care system. According to the World Health Organization, 70% of dementia diagnoses can be attributed to Alzheimer's Disease (AD) which is a progressive neurodegenerative disease. AD is detectable in elderly people, mainly over the age of 60, with two-thirds of diagnosed patients being women. Cognitive and memory dysfunctions are the most commonly recognized symptoms of AD, however, neuropsychiatric symptoms such as social withdrawal, anxiety and depression are observed decades prior to cognitive impairment. These behavioural changes are associated with increased conversion from mild cognitive impairment to AD. Evidence from post-mortem AD tissue indicates that the dorsal raphe nucleus (DRN), which contains the majority of serotonin neurons, is one of the initial sites to display tau pathology in the AD brain. Serotonin neurons are critical for emotional regulation and are degenerated in the AD brain. Here, using a viral approach, we developed a mouse model that expresses a tau isoform that is prone to hyperphosphorylation (hTauP301L) specifically in serotonin neurons. We performed a comprehensive behavioural analysis to determine the effects of pathological tau expression in serotonin neurons on anxiety-like, anhedonia-like behaviours, sociability, stress coping strategies and cognition. We found that about fifty percent of serotonin neurons in DRN expressed hTauP301L without changing serotonin density. The hTauP301L group mice showed increased anxiety-like behaviour, hyperactivity, sociability changes, and active stress coping strategy. Lastly, female hTauP301L mice showed slight impairment in contextual information processing and spatial working memory. Understanding the mechanisms underlying neuropsychiatric symptoms and teasing out any causal relationship has the potential to significantly facilitate our understanding of AD symptomatology and pathology.
Wage Earner
Creators: name: Alavijeh, Saeed Abdollahi
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Immigration
subject: Wage Earner
subject: Canada
subject: Identity
subject: Adaptation
subject: Environmental Portraits
subject: Diasporas
subject: Fine Arts

description: The complex process of economic and cultural displacement that newcomers to Canada experience is examined in this Master of Fine Arts thesis. This supplementary essay begins with a study of the difficulties faced by immigrants in Canada and how these difficulties affect their professional careers. Due to these difficulties, some of these groups of people find themselves stuck in blue-collar jobs for a while, though for some it may take longer depending on a number of factors. This paper places my method of visual story telling in the context of this artistic path and positions my work within the field of contemporary photography through a discussion of some contemporary photography works, both my own and those of my contemporaries. After that, I discuss how I try to portray an accurate and sympathetic representation of the immigrant experience in my photography by using my personal experiences and background to inform my approach. Furthermore, I go into detail about how I went about creating this project, how I built relationships with my subjects, and how our experiences are shared. I also explain why I'm using text, how it can help viewers connect with the narration, and how it can help viewers understand the characters' actual lives.
Additional file 1 of Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells
Creators: name: Huang, Le-Tian
name: Li, Tie-Jun
name: Li, Ming-Lin
name: Luo, Han-Yong
name: Wang, Yi-Bing
name: Wang, Jia-He
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. A. UHPLC-Obitrap MS BPC of quality control samples shows high precision. B. Pearson correlation analysis of QC samples shows good reproducibility. C. Principal component analysis (PCA) analysis shows a good experimental repeatability.
The Saito-Kurokawa lifting and Darmon points
Creators: name: Longo, Matteo
name: Nicole, Marc-Hubert
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11F30, 11F32, 11F46, 11F85

description: Let $E_{/_\Q}$ be an elliptic curve of conductor $Np$ with $p\nmid N$ and let $f$ be its associated newform of weight 2. Denote by $f_\infty$ the $p$-adic Hida family passing though $f$, and by $F_\infty$ its $Λ$-adic Saito-Kurokawa lift. The $p$-adic family $F_\infty$ of Siegel modular forms admits a formal Fourier expansion, from which we can define a family of normalized Fourier coefficients $\{\widetilde A_T(k)\}_T$ indexed by positive definite symmetric half-integral matrices $T$ of size $2\times 2$. We relate explicitly certain global points on $E$ (coming from the theory of Stark-Heegner points) with the values of these Fourier coefficients and of their $p$-adic derivatives, evaluated at weight $k=2$.
description: 14 pages. Title changed
The Structure of Intelligence in Youth with Specific Learning Disorders
Creators: name: Robinson, Nicolas M.
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Specific Learning Disorder
subject: Intelligence
subject: Cognitive Assessment
subject: Educational Psychology

description: Research indicates that youth with specific learning disorders (SLDs) exhibit a pattern of cognitive strengths and weaknesses that is distinct from that of typically developing children. The WISC is a standardized measure of cognitive ability that is widely used in the assessment of SLD, and updates from the WISC-IV to WISC-V allow for an enhanced measurement of the processing strengths and weaknesses in this population. The primary goal of the current study was to investigate the pattern of cognitive performance unique to each SLD subtype on the WISC-V. The WISC-V scores of individuals diagnosed with SLD were compared across subtypes and relative to a non-SLD control group at the composite, index, and subtest levels. The results showed that compared to their non-SLD peers (n = 184), youth with SLD (n = 245) exhibited deficits across all WISC-V domains except visual-spatial reasoning. Analyses between SLD subtypes in writing (n = 36), reading (n = 17), and math (n = 25) revealed differential patterns of performance in verbal, fluid, and visual-spatial reasoning, but consistent performance with respect to working memory and processing speed. Results from this study have the potential to contribute to practitioners' understanding of the cognitive processes that lead to impairments in specific academic domains. It is anticipated that these patterns hold relevance for both assessment and intervention.
符以载道：北美图书馆拼音转换廿周年口述访谈及文献资料汇辑Celebrating 20th Anniversary of the Pinyin Conversion Project in North American Libraries: A Collection of Interviews, Documents, and Publications
Creators: name: Chen, Yao
name: Gan, Lucy
name: Li, Xiang
name: Wang, Chengzhi
Publisher: name: Unknown
Year: 2023
Subjects: subject: Romanization rules
subject: Pinyin
subject: Wade-Giles
subject: Chinese
subject: East Asian Libraries
subject: North America

description: 2020年，本书编者开展了回顾和纪念北美图书馆汉语拼音转换项目二十周年活动，对当年参与拼音转换工作的部分图书馆员进行了线上口述访谈。这里，我们将完整的口述访谈录及拼音转换相关代表性文献编辑成这本《符以载道：北美图书馆拼音转换廿周年口述访谈及文献资料汇辑》。我们旨在以此书纪念汉语拼音转换完成二十周年，并向参与转换的前辈同仁们致敬；并真诚地希望本书能促进我们回顾、学习和重新思考世纪之交北美东亚图书馆界的拼音转换历史，并在信息技术迅速发展、图书编目规则和系统不断变化的新环境中，不辍传承，勇于创新，继往开来。 In 2020, we initiated an oral history project to commemorate the 20th anniversary of the Pinyin Conversion Project, a collaborative effort to standardize the Romanization of Chinese characters in North American libraries. We interviewed librarians who actively participated in and contributed to the project and compiled their stories and diverse documents into this volume. This book serves as a tribute to our colleagues and a valuable resource for understanding the challenges, opportunities, and implications of the Pinyin conversion project. We aspire for it to inspire librarians to reflect on the past and future of Chinese cataloging and Chinese Studies librarianship amid the evolving digital age and complexities of national and international dynamics.
Additional file 9: of Genome-wide analysis of genes encoding core components of the ubiquitin system in soybean (Glycine max) reveals a potential role for ubiquitination in host immunity against soybean cyst nematode
Creators: name: Zhang, Chunyu
name: Song, Li
name: Choudhary, Mani
name: Zhou, Bangjun
name: Sun, Guangchao
name: Broderick, Kyle
name: Giesler, Loren
name: Zeng, Lirong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Figure S6. Multiple sequence alignments of the F-box domain from the soybean F-box domain-containing proteins. (PDF 52 kb)
Plasticity of Reproductive Traits in Response to Pollen-Limited Fruit Initiation in an Annual Plant
Creators: name: Mount, Nathaniel James Hamnett
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Pollen-Limitation
subject: Ecology
subject: FOS: Biological sciences
subject: Botany

description: Pollination is a highly uncertain and variable process, and insufficient pollination commonly limits seed production and siring success by flowering plants. Due to this unpredictability, plants, particularly those with annual or otherwise semelparous life-histories, could benefit from phenotypic plasticity in their reproductive growth and function that enhances the overall likelihood of pollination and provides some compensation for pollen limitation. To test this hypothesis, three hand-pollination experiments were conducted using a rapid-cycling variety of Brassica rapa to determine whether limited pollination stimulated plastic responses that could increase seed production relative to the fecundity that would be realized in the absence of plasticity. Plants on which a limited fraction of flowers had been pollinated exhibited many differences from well-pollinated plants. Compared to well-pollinated plants, pollination of 25% of a plant’s flowers reduced fruit production, indicating pollen limitation. In contrast, fruit number did not vary with pollination if at least 50% of flowers were pollinated, indicating resource limitation. In response to pollen limitation, poorly pollinated plants produced more flowers than well-pollinated plants, which should increase their overall pollination success. Neither pollen number per flower on terminal racemes nor its siring ability varied with pollination success. However, plants with few developing fruits produced more ovules in distal flowers of their axillary racemes and more seeds per distal fruit on all racemes compared to plants with many developing fruits. Pollen-limited plants with relatively few seeds overall produced larger seeds, which should enhance seed germination and seedling establishment. Overall, pollen-limited plants also opened fewer flowers per day, extending their total flowering period and exposure to pollinators. Nevertheless, pollen-limited plants opened more flowers per day during late flowering, which increased the number of flowers displayed simultaneously and should enhance pollinator attraction. These results indicate that, rather than being helpless against pollen limitation, plasticity of reproductive characteristics allows annual plants to compensate, at least partially, for low per-flower pollination probability.
Report on the exchange visits learnings in the six SmartCulTour Living Labs
Creators: name: Mandić, Ante
name: Petrić, Lidija
name: Vrgoč, Monika
name: Kerst, Iris
name: Koens, Ko
name: Ferdinandus, Joël
name: Lioce, Raffaella
name: Bettin, Michel
name: Shomali, Kalid W.
name: Maltauro, Manuela
name: Alhonsuo, Mira
name: Björn, Ella
name: Juste, Rocio
name: Lozano, Diego
name: Geudens, Griet
name: Neuts, Bart
Publisher: name: Zenodo
Year: 2022
Subjects: Living Labs
Exchange visits
Innovation networks

description: The present Deliverable 6.3 - “Report on the exchange visits learnings in the six SmartCulTour Living Labs” focuses on the hosting and travelling exchange experiences that have been undertaken among the six SmartCulTour Living Laboratories between May and October 2022. The main objective of such activities was to strengthen international cooperation between researchers, advisors and local stakeholders participating in the network of the Labs, develop opportunities for further international cooperation and learning, and support the transfer of knowledge on practical initiatives that could positively influence sustainable cultural tourism development at destination level. In order to boost the relevance of the learning experience, the Living Labs were divided into two groups, based on their typological and geographical coverage: the Split, Rotterdam and Vicenza Living Labs were gathered in an “urban cluster”, while the Utsjoki, Scheldeland and Huesca Living Lab were combined in a “rural cluster”. The exchange reports herein presented are divided per cluster and according to the chronological order of the visits. From a content-wise perspective, the exchange programmes of the Labs within the same cluster - urban or rural - have been designed with a view to maximising overall coherence and complementarity between the different strands of the activity. This report aims at presenting the objectives and results of the exchange programme hosted by each Living Lab, in light of its linkages with the experiences offered by the other two Labs of the same group, as well as the key persons met and potential opportunities for future development and cooperation. Overall, the exchange visit learnings were considered successful from both hosting and travelling Living Labs’ participants, as they proved to be helpful for LLs to test pilot and prototype interventions, exchange good practices on common challenges, and further delve into the potential for cultural tourism development linked to territorial resources, by also relying upon the feedback and inputs of other Labs’ academics and professionals from the cultural and tourism sector.
On the inverse Klain map
Creators: name: Parapatits, Lukas
name: Wannerer, Thomas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 52A20 (Primary) 52B45, 52A40 (Secondary)

description: The continuity of the inverse Klain map is investigated and the class of centrally symmetric convex bodies at which every valuation depends continuously on its Klain function is characterized. Among several applications, it is shown that McMullen's decomposition is not possible in the class of translation-invariant, continuous, positive valuations. This implies that there exists no McMullen decomposition for translation-invariant, continuous Minkowski valuations, which solves a problem first posed by Schneider and Schuster.
description: 21 pages; typos fixed
MITOCHONDRIAL SKELETAL DISORDERS PROVIDE INSIGHT INTO THE EFFECT OF MITOCHONDRIAL PROTEOSTATIC STRESS ON STEROIDOGENESIS
Creators: name: Zhao, Tian Rui
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: mitochondria
subject: mitochondrial diseases
subject: PISD
subject: STARD1
subject: LONP1
subject: steroidogenesis
subject: mitochondrial skeletal disorders
subject: mitochondrial protein homeostasis
subject: stress
subject: Genetics
subject: FOS: Biological sciences
subject: Biology--Molecular
subject: Biochemistry

description: Mitochondria are best known for their role in energy production, and impairments in this essential function are generally thought to cause mitochondrial disease, which typically affects organs and tissues with high energy demand. However, increasing evidence shows that impairments to other critical mitochondrial functions such as lipid metabolism, and steroidogenesis can also contribute to mitochondrial diseases. In this thesis, we identified a group of mitochondrial diseases where mitochondrial protein homeostasis is disrupted, which we termed mitochondrial skeletal disorders, as the patients exhibited phenotypes such as skeletal dysplasia, short stature, and cataracts. In addition, further investigation identified a potential mechanism by which altered mitochondrial protein homeostasis and increased steroidogenesis may contribute to these patient phenotypes. First, we identified novel pathogenic variants in phosphatidylserine decarboxylase (PISD) gene from patients with short stature, neurodevelopmental issues, and cataracts. We demonstrated that the variants impair function and stability of PISD and are likely causative of their disease. We also identified evidence for impaired activity of inner mitochondrial membrane (IMM) proteases, suggesting dysfunctions in mitochondrial protein homeostasis. To further investigate the mechanism by which impaired mitochondrial proteostasis may lead to these phenotypes, we tested the hypothesis that impaired mitochondrial proteostasis can lead to overproduction of the stress hormone cortisol, as this could potentially explain the patients’ phenotypes described above. Using both pharmacological and genetic stresses to impair mitochondrial proteostasis, we showed impaired mitochondrial protein import activates STARD1, a mitochondrial protein crucial in steroidogenesis. We then showed that increased cortisol production is STARD1 dependent and follows a biphasic response to mitochondrial stress. Overall, these findings expand our current understanding of mitochondrial disease and link mitochondrial quality control and steroidogenesis as potential disease mechanisms.
Development of anti-counterfeiting program in East Africa
Creators: name: Boef, Walter De
name: Hasson, Orin
name: Mennel, John
name: Prabhala, Pradeep
name: Bryce, Joel
name: Bumb, Nikhil
name: Adachi, Michie
name: Anderson, Kelsey
Publisher: name: Gates Open Research
Year: 2019

description: Development of anti-counterfeiting program in East Africa
Perception and Production of a Quantity-Sensitive Stress System in Adults and Children: The case of Levantine Arabic in Canada
Creators: name: Abdalla, Summer Mohamed
Publisher: name: Arts
Year: 2023
Subjects: subject: Arabic
subject: Linguistics
subject: FOS: Languages and literature
subject: Development
subject: Psycholinguistics
subject: Prosody
subject: Word Stress
subject: Linguistics

description: In this Master’s thesis, I explored the aspects of stress in the Levantine Arabic dialects and the developmental trajectory of stress among L1 speakers. Arabic exhibits a bimoraic trochaic structure, with primary word stress assigned to the rightmost foot in a word. Previous research on the Arabic stress system has focused mainly on phonetic cues of stress in production or the effects on L2 acquisition. There is little information on the perceptual abilities of L1 Arabic speakers, but findings from fixed, quantity-insensitive systems like French suggest that Arabic speakers might also be stress insensitive. However, there is a possibility that the language’s quantity-sensitive nature supports speakers in stress perception since the location of stress is not fixed to one syllable location. It is also important to understand how such a system is developed in children, who need to be sensitive to acquire the phonological structures related to stress. The main research questions addressed in this thesis are twofold: (i) whether adult L1 Arabic speakers demonstrate stress insensitivity, and (ii) whether sensitivity to stress changes during the developmental stages of L1 Arabic acquisition. To explore these questions, three studies were conducted to assess stress production, perception, and acquisition. The first experiment was a combined production and perception task in which adult participants heard real and nonce Arabic words and had to determine if the stress pattern was correct or incorrect. In the second experiment, I developed a perception-only task where adult participants heard real and nonce words and had to select the correctly stressed version based on the Arabic stress system. The final experiment was an acquisition study testing 3 – 5-year old’s production and perceptual abilities of Arabic stress with the combined production and perception task. The findings reveal that L1 Arabic adult speakers do apply the phonological knowledge of the stress patterns in their productions, but their perceptual sensitivity to stress is limited. In terms of acquisition, L1 Arabic learning children as young as 3 years exhibit perceptual sensitivity and produce stress according to the stress structures of the Arabic system. Therefore, the findings suggest the development of this stress system is in line with other linguistic stress systems.
Matrix powers algorithms for trust evaluation in PKI architectures
Creators: name: Dumas, Jean-Guillaume
name: Hossayni, Hicham
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: This paper deals with the evaluation of trust in public-key infrastructures. Different trust models have been proposed to interconnect the various PKI components in order to propagate the trust between them. In this paper we provide a new polynomial algorithm using linear algebra to assess trust relationships in a network using different trust evaluation schemes. The advantages are twofold: first the use of matrix computations instead of graph algorithms provides an optimized computational solution; second, our algorithm can be used for generic graphs, even in the presence of cycles. Our algorithm is designed to evaluate the trust using all existing (finite) trust paths between entities as a preliminary to any exchanges between PKIs. This can give a precise evaluation of trust, and accelerate for instance cross-certificate validation.
Ambivalent ambulation : fan pilgrimage and the itinerantextual cult film
Creators: name: Cannon, Jonathan Ambrose
Publisher: name: University of British Columbia
Year: 2012

description: Peripatetic by nature yet polymorphous in form, the topic of fan pilgrimage expresses a significant dearth in cult film and media scholarship. Whilst the concept of pilgrimage has been classically linked to religious duty and moral obligation, its ability to straddle both traditionalist and secularist rationales amidst increased globalisation makes such ambiguous mobility ripe for closer analysis. In this thesis, I will theorise fan pilgrimage using a series of itinerant fan taxonomies to recontextualise the role of the pilgrim and its function within select fan groups. Utilising the critical literature of Zygmunt Bauman, Victor Turner, and Roger C. Aden, respectively, Chapter 1 reevaluates ideas of community and reconfigures the spatiotemporal theories of performance articulated by Richard Schechner through fan pilgrimage and performative communitas. Chapter 2 explores how theories of play and everyday life create my first fan taxonomy: the ludic pilgrim. Via the play theory of Johan Huizinga and Roger Caillois as well as the theories of everyday life held by Erving Goffman, I argue for a correlation between play and costume through the case study of the otaku – i.e. fans of Japanese anime and manga. Chapter 3 employs fashion theory to subcultural style and reconsiders the value of the goth subculture and female vampire fandom by way of my second fan taxonomy: the subsartorial pilgrim. In Chapter 4, The Rocky Horror Picture Show serves as my main case study to theorise subcultural liveness during screenings of Rocky Horror and highlight my third fan taxonomy: the performative pilgrim. Examining the pilgrim as tourist through concepts such as fan tourism and flâneurism and by way of case studies such as Blade Runner, Disney theme parks, and The Lord of the Rings blockbuster trilogy, Chapter 5 unpacks my fourth fan taxonomy: the postmodern pilgrim. Finally, Chapter 6 recasts The Big Lebowski as a cult film that is primarily consumed by fans via Lebowski Fest. This chapter will elucidate how narrative, replay culture, and the documentary film The Achievers: The Story of the Lebowski Fans all reshape the meaning of Lebowski and spotlight its classification as an itinerantextual cult film.
Using prior-data conflict to tune Bayesian regularized regression models
Creators: name: Biziaev, Timofei
Publisher: name: Arts
Year: 2023
Subjects: subject: Biostatistics
subject: Bayesian statistics
subject: Biostatistics

description: In high-dimensional regression models, variable selection becomes challenging from a computational and theoretical perspective. Bayesian regularized regression via shrinkage priors like the Laplace or spike-and-slab prior are effective methods for variable selection in p > n scenarios provided the shrinkage priors are configured adequately. We propose configuring shrinkage priors using checks for prior-data conflict: tests that assess whether there is disagreement in parameter information provided by the prior and data. We apply our proposed method to the Bayesian LASSO and spike-and-slab shrinkage priors and assess variable selection performance of our prior configurations against competing models through a linear and logistic high-dimensional simulation study. Additionally, we apply our method to proteomic data collected from patients admitted to the Albany Medical Center in Albany NY in April of 2020 with COVID-like respiratory issues. Simulation results suggest our proposed configurations may outperform competing models when the true regression effects are small.
Additional file 2 of Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells
Creators: name: Huang, Le-Tian
name: Li, Tie-Jun
name: Li, Ming-Lin
name: Luo, Han-Yong
name: Wang, Yi-Bing
name: Wang, Jia-He
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2. Lipid profiling of papillary thyroid carcinoma cell between two groups.
Neural Basis of Arousal Signaling for Non-Photic Resetting of the Circadian Clock
Creators: name: Moshirpour, Mahtab
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Circadian Rhythms
subject: Circadian Clock
subject: Neuroscience
subject: Orexin
subject: Glutamate
subject: Acetylcholine
subject: Adenosine
subject: Neuroscience
subject: Psychology--Experimental

description: Input to the suprachiasmatic nucleus (SCN) from the intergeniculate leaflet (IGL) is necessary for non-photic entrainment. However, the underlying mechanisms of IGL activation remain unknown. There are several arousal centers in the brain that could be involved in bringing about non-photic entrainment. These include the lateral hypothalamus (LH) which contains clock-projecting orexin cells, and the cholinergic basal forebrain that directly communicates with the SCN. Even though arousal is the key component of non-photic entrainment, the relationship between the IGL and these arousal areas is unclear. We investigated the neural basis of arousal signaling by first studying the potential inputs to the IGL from the LH and the basal forebrain of Syrian hamsters. Projections to the IGL, from both the LH and the basal forebrain cholinergic cells were found. Next, we examined whether orexin is necessary and sufficient for non-photic phase shifting by both blocking orexin prior to an arousal-inducing protocol such as sleep deprivation and administering orexin in the IGL. It was found that orexin alone is not necessary or sufficient to cause shifts. Instead, it was found that dual administration of a glutamate receptor agonist with orexin is sufficient to cause significant shifts, suggesting an additive effect at the IGL. We next examined whether acetylcholine is necessary for non-photic entrainment. No attenuation of the arousal-induced response was observed by blocking acetylcholine at the IGL, suggesting that it is not necessary for non-photic entrainment, though it has been reported to be critical at the SCN level. Finally, accumulation of the sleep factor adenosine in the basal forebrain was mimicked as a potential signal for activating the basal forebrain. No significant phase shifts or cellular activation of the basal forebrain was observed after blocking adenosine at the basal forebrain. Taken together, the results present the first report of a dual role for orexin and glutamate in potentially gating the IGL’s non-photic inputs to the SCN.
Additional file 3 of Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells
Creators: name: Huang, Le-Tian
name: Li, Tie-Jun
name: Li, Ming-Lin
name: Luo, Han-Yong
name: Wang, Yi-Bing
name: Wang, Jia-He
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3. Lipid class analysis between two groups.