cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Addressing challenges in fitting bi-exponential DW-MRI data
Creators: name: Manikis, Georgios
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Computer applications
subject: Oncology
subject: MR-Diffusion/Perfusion
subject: Computer Applications-Detection, diagnosis
subject: Neoplasia
subject: Abscess
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: This study aims to elucidate aspects of IVIM fitting procedure that may obscure the true contribution of pseudo-diffusion to a multi-b-value DWI acquisition scheme.The vast majority concludes on the significance of D and f in aiding diagnosis, while...
Modulation of Ethanol Withdrawal???Induced Anxiety-Like Behavior During Later Withdrawals by Treatment of Early Withdrawals With Benzodiazepine/??-Aminobutyric Acid Ligands
Creators: name: Breese, George R.
name: Knapp, Darin J.
name: Overstreet, David H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Anxiety states, including those arising during acute or protracted withdrawal periods, may be precipitating factors in alcoholic relapse. Given the cyclical nature of ethanol withdrawal associated with repeated cycles of ethanol intake and abstinence in a pattern that often spans years, meaningful attempts to model ethanol withdrawal–associated anxiety should incorporate cycled ethanol treatments. The studies reported herein examined the effects of γ-aminobutyric acid–modulating drugs on social interaction behavior—an established model of anxiety—in rats exposed to repeated cycles of ethanol treatment and withdrawal.
title: MR-guided high intensity focused ultrasound (MRgFUS) for the treatment of oligometastatic prostate cancer bone disease
Creators: name: Napoli, Alessandro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Musculoskeletal bone
subject: Oncology
subject: MR
subject: MR-Functional imaging
subject: PET
subject: Ablation procedures
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Prostate cancer is the most common non-cutaneous malignant tumor diagnosed in men. As in other malignancies, the presence of metastasis is considered one of the most impactful factors on patient prognosis. Bone represent the most common site of...
(100955) Frances Daubeny
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Effectiveness of endovascular treatment in patients with Behçet's disease
Creators: name: Sahin, Can
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Vascular
subject: CT-Angiography
subject: Catheter arteriography
subject: CT
subject: Embolisation
subject: Stents
subject: Balloon occlusion
subject: Aneurysms

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Behçet’s disease is a chronic relapsing systemic vasculitis that can involve almost every organ and systems in the body with extremely different diverse manifestations. Vascular involvement in Behçet's disease can lead to life threatening...
Review—Emerging Portable Technologies for Gait Analysis in Neurological Disorders
Creators: name: Salchow-Hömmen, Christina
name: Skrobot, Matej
name: Jochner, Magdalena C. E.
name: Schauer, Thomas
name: Kühn, Andrea A.
name: Wenger, Nikolaus
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 610 Medizin und Gesundheit
subject: motion tracking
subject: human kinematics
subject: locomotion
subject: postural control
subject: wearables
subject: digital image processing
subject: Parkinson's disease
subject: multiple sclerosis

description: The understanding of locomotion in neurological disorders requires technologies for quantitative gait analysis. Numerous modalities are available today to objectively capture spatiotemporal gait and postural control features. Nevertheless, many obstacles prevent the application of these technologies to their full potential in neurological research and especially clinical practice. These include the required expert knowledge, time for data collection, and missing standards for data analysis and reporting. Here, we provide a technological review of wearable and vision-based portable motion analysis tools that emerged in the last decade with recent applications in neurological disorders such as Parkinson's disease and Multiple Sclerosis. The goal is to enable the reader to understand the available technologies with their individual strengths and limitations in order to make an informed decision for own investigations and clinical applications. We foresee that ongoing developments toward user-friendly automated devices will allow for closed-loop applications, long-term monitoring, and telemedical consulting in real-life environments.
title: Proof of principle: virtual simulation of operative procedures using open source 3D-rendering and CAD software
Creators: name: Haubold, Johannes
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Computer applications
subject: Bones
subject: Musculoskeletal system
subject: CAD
subject: CT-High Resolution
subject: CT
subject: CAD
subject: Computer Applications-3D
subject: Computer Applications-Virtual imaging
subject: Trauma
subject: Foreign bodies
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: 2015's annual statistic of medical errors in treatment in Germany showed that 43% of all errors in the medical sector were caused in surgical departments. 1 Meanwhile, preoperative planning is mainly based on 2D datasets ignoring the angle and the...
Additional file 1 of A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) — a randomised feasibility study using the trial within a cohort (TwiC) methodology
Creators: name: Bibby, Anna C.
name: Zahan-Evans, Natalie
name: Keenan, Emma
name: Comins, Charles
name: Harvey, John E.
name: Day, Helen
name: Rahman, Najib M.
name: Fallon, Janet E.
name: Gooberman-Hill, Rachael
name: Maskell, Nick A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 1: Appendix A. TILT protocol.
Testing general relativity with TianQin: the prospect of using the inspiral signals of black hole binaries
Creators: name: Shi, Changfu
name: Ji, Mujie
name: Zhang, Jian-dong
name: Mei, Jianwei
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we carry out a systematic study of the prospect of testing general relativity with the inspiral signals of black hole binaries that could be detected with TianQin. The study is based on the parameterized post-Einsteinian (ppE) waveform, so that many modified gravity theories can be covered simultaneously. We consider black hole binaries with total masses ranging from $10\rm M_\odot\sim10^7 M_\odot$ and ppE corrections at post-Newtonian (PN) orders ranging from $-4$PN to $2$PN. Compared to the current ground-based detectors, TianQin can improve the constraints on the ppE phase parameter $β$ by orders of magnitude. For example, the improvement at the $-4$PN and $2$PN orders can be about $13$ and $3$ orders of magnitude (compared to the results from GW150914), respectively. Compared to future ground-based detectors, such as ET, TianQin is expected to be superior below the $-1$PN order, and for corrections above the $-0.5$PN order, TianQin is still competitive near the large mass end of the low mass range $[10 \rm M_\odot, \,10^3 \rm M_\odot]\,$. Compared to the future space-based detector LISA, TianQin can be competitive in the lower mass end as the PN order is increased. For example, at the $-4$PN order, LISA is always superior for sources more massive than about $30\rm M_\odot\,$, while at the $2$PN order, TianQin becomes competitive for sources less massive than about $10^4\rm M_\odot$. We also study the scientific potentials of detector networks involving TianQin, LISA and ET, and discuss the constraints on specific theories such as the dynamic Chern-Simons theory and the Einstein-dilaton Gauss-Bonnet theory.
title: Age estimation through post-mortem CT evaluation of metaphysis and pelvic ossification nuclei in migrants victim of ship sinking
Creators: name: Scopelliti, Laura
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Forensic / Necropsy studies
subject: Bones
subject: Extremities
subject: CT
subject: Image manipulation / Reconstruction
subject: Ethics
subject: Medico-legal issues

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: During spring of 2015 a ship sinking occurred in Mediterranean sea near Libyan waters. An overcrowded boat drowned killing the great majority of its passengers with 700 estimated victims. After preliminary analysis it was established that all of...
title: Treatment of intracranial aneurysms with flow-diverting stents: results of a monocentric study
Creators: name: Del Sette, Bruno
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: Vascular
subject: CNS
subject: CT-Angiography
subject: MR-Angiography
subject: Catheter arteriography
subject: Stents
subject: Embolisation
subject: Aneurysms
subject: Haemodynamics / Flow dynamics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Treatment of cerebral aneurysm represents a major challenge for specialists in the field; with the introduction of new techniques and materials, endovascular therapy isbeginning to have wider indications. The aim of our study was to evaluate the...
Neurotrophic Factor Signaling in Alcoholism
Creators: name: Crews, Fulton T.
name: Saito, Toshikazu
name: Ukai, Wataru
name: Pandey, Subhash C.
name: Nixon, Kim
name: Chandler, L. J.
name: Hensler, Julie G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: This article presents the proceedings of a symposium presented at the meeting of the International Society for the Biomedical Research on Alcoholism (ISBRA), held in Manheim, Germany, in September 2004. The organizers and chairpersons were Subhash C. Pandey and Toshikazu Saito. The presentations were (1) Ethanol and NMDA receptor coupling to ERK signaling, by L.J. Chandler;(2) Ethanol modulation of CREB: Role in neurogenesis, by Fulton Crews;(3) Serotonin dysfunction and alcohol preference in mice deficient in brain-derived neurotrophic factor (BDNF), by Julie G. Hensler; (4) BDNF gene and related signaling: role in anxiety and alcohol dependence and preference, by Subhash C. Pandey; (5) BDNF and CREB: role in ethanol induced neuronal damage, Wataru Ukai.
Additional file 2 of A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) — a randomised feasibility study using the trial within a cohort (TwiC) methodology
Creators: name: Bibby, Anna C.
name: Zahan-Evans, Natalie
name: Keenan, Emma
name: Comins, Charles
name: Harvey, John E.
name: Day, Helen
name: Rahman, Najib M.
name: Fallon, Janet E.
name: Gooberman-Hill, Rachael
name: Maskell, Nick A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 2: Appendix B. Trial Specific Procedure for IMP administration.
Stress Enhancement of Craving During Sobriety: A Risk for Relapse
Creators: name: Weiss, Friedbert
name: Chu, Kathleen
name: Roberts, Amanda J.
name: Overstreet, David H.
name: Dayas, Christopher V.
name: Valdez, Glenn R.
name: Lê, Dzung Anh
name: Funk, Douglas
name: O'Dell, Laura E.
name: Knapp, Darin J.
name: Sinha, Rajita
name: Koob, George F.
name: Breese, George R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: This report of the proceedings of a symposium presented at the 2004 Research Society on Alcoholism Meeting provides evidence linking stress during sobriety to craving that increases the risk for relapse. The initial presentation by Rajita Sinha summarized clinical evidence for the hypothesis that there is an increased sensitivity to stress-induced craving in alcoholics. During early abstinence, alcoholics who were confronted with stressful circumstances showed increased susceptibility for relapse. George Breese presented data demonstrating that stress could substitute for repeated withdrawals from chronic ethanol to induce anxiety-like behavior. This persistent adaptive change induced by multiple withdrawals allowed stress to induce an anxiety-like response that was absent in animals that were not previously exposed to chronic ethanol. Subsequently, Amanda Roberts reviewed evidence that increased drinking induced by stress was dependent on corticotropin-releasing factor (CRF). In addition, rats that were stressed during protracted abstinence exhibited anxiety-like behavior that was also dependent on CRF. Christopher Dayas indicated that stress increases the reinstatement of an alcohol-related cue. Moreover, this effect was enhanced by previous alcohol dependence. These interactive effects between stress and alcohol-related environmental stimuli depended on concurrent activation of endogenous opioid and CRF systems. A.D. Lê covered information that indicated that stress facilitated reinstatement to alcohol responding and summarized the influence of multiple deprivations on this interaction. David Overstreet provided evidence that restraint stress during repeated alcohol deprivations increases voluntary drinking in alcohol-preferring (P) rats that results in withdrawal-induced anxiety that is not observed in the absence of stress. Testing of drugs on the stress-induced voluntary drinking implicated serotonin and CRF involvement in the sensitized response. Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress.
Redundancy of Fusion frames in Hilbert Spaces
Creators: name: Rahimi, Asghar
name: Zandi, Golaleh
name: Daraby, Bayaz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 42C40, Secondary 41A58, 47A58

description: Upon improving and extending the concept of redundancy of frames, we introduce the notion of redundancy of fusion frames, which is concerned with the properties of lower and upper redundancies. These properties are achieved by considering the minimum and maximum values of the redundancy function which is defined from the unit sphere of the Hilbert space into the positive real numbers. In addition, we study the relationship between redundancy of frames (fusion frames) and dual frames (dual fusion frames). Moreover, we indicate some results about excess of fusion frames. We state the relationship between redundancy of local frames and fusion frames in a particular case. Furthermore, some examples are also given.
Basis of the Gabamimetic Profile of Ethanol
Creators: name: Khisti, R. T.
name: Carta, M.
name: Siggins, G. R.
name: Wallner, M.
name: Valenzuela, C. F.
name: Hanchar, H. J.
name: Olsen, R. W.
name: Breese, G. R.
name: Morrow, A. L.
name: Mameli, M.
name: Roberto, M.
name: Ming, Z.
name: Penland, S. N.
name: Otis, T. S.
name: Parsons, L. H.
name: Dodson, P. D.
name: Criswell, H. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: This article summarizes the proceedings of a symposium held at the 2005 Research Society on Alcoholism meeting. The initial presentation by Dr. Wallner provided evidence that selected GABAA receptors containing the δ subunit display sensitivity to low intoxicating ethanol concentrations and this sensitivity is further increased by a mutation in the cerebellar α6 subunit, found in alcohol-hypersensitive rats. Dr. Mameli reported that ethanol affects γ-aminobutyric acid (GABA) function by affecting neural circuits that influence GABA release. Dr. Parsons presented data from electrophysiological and microdialysis investigations that ethanol is capable of releasing GABA from presynaptic terminals. Dr. Morrow demonstrated that systemic ethanol increases neuroactive steroids in brain, the absence of which alters various functional responses to ethanol. Dr. Criswell presented evidence that the ability of ethanol to increase GABA was apparent in some, but not all, brain regions indicative of regional specificity. Further, Dr. Criswell demonstrated that neurosteroids alone and when synthesized locally by ethanol act postsynaptically to enhance the effect of GABA released by ethanol in a region specific manner. Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABAA receptors.
title: CTA/CTP patient selection before mechanical thrombectomy by a direct aspiration, first pass technique (ADAPT): results of a monocentric study
Creators: name: Del Sette, Bruno
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: CNS
subject: Interventional vascular
subject: CT
subject: CT-Angiography
subject: Catheter arteriography
subject: Thrombolysis
subject: Recanalisation
subject: Acute
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Use of endovascular treatments for patients with ischemic stroke due to major vessel occlusionis increasingin therecent years, according to guidelines and due to the introduction of new aspiration devices which are leading to a reduction of...
Affine Algebras at Infinite Distance Limits in the Heterotic String
Creators: name: Collazuol, Veronica
name: Graña, Mariana
name: Herráez, Alvaro
name: De Freitas, Héctor Parra
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze the boundaries of the moduli spaces of compactifications of the heterotic string on $T^d$, making particular emphasis on $d=2$ and its F-theory dual. We compute the OPE algebras as we approach all the infinite distance limits that correspond to (possibly partial) decompactification limits in some dual frame. When decompactifying $k$ directions, we find infinite towers of states becoming light that enhance the algebra arising at a given point in the moduli space of the $T^{d-k}$ compactification to its $k$-loop version, where the central extensions are given by the $k$ KK vectors. For $T^2$ compactifications, we reproduce all the affine algebras that arise in the F-theory dual, and show all the towers explicitly, including some that are not manifest in the F-theory counterparts. Furthermore, we construct the affine $SO(32)$ algebra arising in the full decompactification limit, both in the heterotic and in the F-theory sides, showing that not only affine algebras of exceptional type arise in the latter.
description: 51 pages, 10 figures
Additional file 3 of A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) — a randomised feasibility study using the trial within a cohort (TwiC) methodology
Creators: name: Bibby, Anna C.
name: Zahan-Evans, Natalie
name: Keenan, Emma
name: Comins, Charles
name: Harvey, John E.
name: Day, Helen
name: Rahman, Najib M.
name: Fallon, Janet E.
name: Gooberman-Hill, Rachael
name: Maskell, Nick A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 3: Appendix C. Average IPC drainage volumes (mean & 95% confidence intervals) at each trial visit for participants randomised to receive OK432 or BCG (IMP group) and controls.
The game story space of professional sports: Australian Rules Football
Creators: name: Kiley, D. P.
name: Reagan, A. J.
name: Mitchell, L.
name: Danforth, C. M.
name: Dodds, P. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Sports are spontaneous generators of stories. Through skill and chance, the script of each game is dynamically written in real time by players acting out possible trajectories allowed by a sport's rules. By properly characterizing a given sport's ecology of `game stories', we are able to capture the sport's capacity for unfolding interesting narratives, in part by contrasting them with random walks. Here, we explore the game story space afforded by a data set of 1,310 Australian Football League (AFL) score lines. We find that AFL games exhibit a continuous spectrum of stories rather than distinct clusters. We show how coarse-graining reveals identifiable motifs ranging from last minute comeback wins to one-sided blowouts. Through an extensive comparison with biased random walks, we show that real AFL games deliver a broader array of motifs than null models, and we provide consequent insights into the narrative appeal of real games.
description: 15 pages, 19 figures
(100949) John E Davies
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 4 of A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) — a randomised feasibility study using the trial within a cohort (TwiC) methodology
Creators: name: Bibby, Anna C.
name: Zahan-Evans, Natalie
name: Keenan, Emma
name: Comins, Charles
name: Harvey, John E.
name: Day, Helen
name: Rahman, Najib M.
name: Fallon, Janet E.
name: Gooberman-Hill, Rachael
name: Maskell, Nick A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 4: Appendix D. Results for patient-reported outcome measures. Figure C1. Patient reported symptom scores (mean and 95% confidence intervals) for breathlessness in people randomised to receive an IMP compared with controls at each study visit. Figure C2. Patient reported symptom scores (mean and 95% confidence intervals) for chest pain for people randomised to receive an IMP compared with controls at each study visit. Figure C3. Patient reported symptom scores (mean and 95% confidence intervals) for sweats in people randomised to receive an IMP compared with controls at each study visit. Figure C4. 1 Patient reported symptom scores (mean and 95% confidence intervals) for quality of life in people randomised to receive OK432 or BCG compared with controls at each study visit.
Competing Presynaptic and Postsynaptic Effects of Ethanol on Cerebellar Purkinje Neurons
Creators: name: Yu, Guozhong
name: Criswell, Hugh E.
name: Ming, Zhen
name: Breese, George R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Ethanol has actions on cerebellar Purkinje neurons that can result either in a net excitation or in inhibition of neuronal activity. The present study examines the interplay of presynaptic and postsynaptic mechanisms to determine the net effect of ethanol on the neuronal firing rate of cerebellar Purkinje neurons.
Symmetry conserving configuration mixing method with cranked states
Creators: name: Borrajo, Marta
name: Rodríguez, Tomás R.
name: Egido, J. Luis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present the first calculations of a symmetry conserving configuration mixing method (SCCM) using time-reversal symmetry breaking Hartree-Fock-Bogoliubov (HFB) states with the Gogny D1S interaction. The method includes particle number and tridimensional angular momentum symmetry restorations as well as configuration mixing within the generator coordinate method (GCM) framework. The nucleus $^{32}$Mg is chosen to show the performance and reliability of the calculations. Additionally, $0^{+}_{1}$, $2^{+}_{1}$ and $4^{+}_{1}$ states are computed for the magnesium isotopic chain, where a noticeable compression of the spectrum is obtained by including cranked states, leading to a very good agreement with the known experimental data.
description: 7 pages, 5 figures, accepted in Physics Letters B
Increased Consumption but Not Operant Self-administration of Ethanol in Mice Lacking the RIIbeta Subunit of Protein Kinase A
Creators: name: Sparta, Dennis R.
name: Breese, George R.
name: Knapp, Darin J.
name: Ferraro III, Frank M.
name: Thiele, Todd E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Accumulating evidence indicates that cAMP-dependent protein kinase A (PKA) is involved in the neurobiological responses to ethanol. Previous reports indicate that mice lacking the RIIβ subunit of PKA (RIIβ−/−) voluntarily consume more ethanol than wild-type controls (RIIβ+/+) using two-bottle testing procedures. While such procedures primarily measure consummatory behavior, operant self-administration procedures allow analysis of consummatory as well as appetitive or “ethanol-seeking” behavior (i.e., lever pressing is required to gain access to the ethanol solution). Therefore, we determined if the high ethanol consumption characteristic of RIIβ−/− mice would be complimented by increased appetitive ethanol-seeking behavior in an operant paradigm.
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
Creators: name: Wilkie, Mary Beth
name: O'Buckley, Todd K.
name: Kelley, Stephen P.
name: Kumar, Sandeep
name: Besheer, Joyce
name: Morrow, A. Leslie
name: Hodge, Clyde W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
title: Minimally invasive treatment of vertebral osteoblastoma using CT-guided percutaneous radiofrequency ablation (RFA): an effective alternative to surgery?
Creators: name: Quarchioni, Simone
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Musculoskeletal spine
subject: Oncology
subject: CT
subject: Ablation procedures
subject: Efficacy studies
subject: Experimental investigations
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Osteoblastoma (OBL) is a rare benign bone tumor, accounting for only 1% of all primary bone tumors (1, 2). It is more common in male (2:1 male to female ratio) in the 2nd or 3rd decades of life (3), four times less frequent than Osteoid Osteoma (OO)...
An unbiased method of measuring the ratio of two data sets
Creators: name: Sun, Zeyang
name: Zhang, Pengjie
name: Dong, Fuyu
name: Yao, Ji
name: Shan, Huanyuan
name: Jullo, Eric
name: Kneib, Jean-Paul
name: Yin, Boyan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In certain cases of astronomical data analysis, the meaningful physical quantity to extract is the ratio $R$ between two data sets. Examples include the lensing ratio, the interloper rate in spectroscopic redshift samples, the decay rate of gravitational potential and $E_G$ to test gravity. However, simply taking the ratio of the two data sets is biased, since it renders (even statistical) errors in the denominator into systematic errors in $R$. Furthermore, it is not optimal in minimizing statistical errors of $R$. Based on Bayesian analysis and the usual assumption of Gaussian error in the data, we derive an analytical expression of the posterior PDF $P(R)$. This result enables fast and unbiased $R$ measurement, with minimal statistical errors. Furthermore, it relies on no underlying model other than the proportionality relation between the two data sets. Even more generally, it applies to the cases where the proportionality relation holds for the underlying physics/statistics instead of the two data sets directly. It also applies to the case of multiple ratios ($R\rightarrow {\bf R}=(R_1,R_2,\cdots)$). We take the lensing ratio as an example to demonstrate our method. We take lenses as DESI imaging survey galaxies, and sources as DECaLS cosmic shear and \emph{Planck} CMB lensing. We restrict the analysis to the ratio between CMB lensing and cosmic shear. The resulting $P(R)$, for multiple lens-shear pairs, are all nearly Gaussian. The S/N of measured $R$ ranges from $4.9$ to $8.4$. We perform several tests to verify the robustness of the above result.
description: 13 pages, 9 figures. Codes available at https://github.com/Ze-yangSUN/Ratio_method
Baclofen Blocks Expression and Sensitization of Anxiety-Like Behavior in an Animal Model of Repeated Stress and Ethanol Withdrawal
Creators: name: Breese, George R.
name: Knapp, Darin J.
name: Overstreet, David H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Repeated exposures to forced ethanol diets (EDs) or restraint stress sensitize anxiety-like behavior during a future ethanol withdrawal. The present investigation assessed whether pretreatment of rats with agents targeting receptor systems thought to be important in treating relapse in alcoholic patients would prevent sensitization of anxiety-like behavior.
title: Quantitatively evaluate the efficacy of advanced diffusion weighted imaging (NODDI and DKI) in grading gliomas
Creators: name: Zhao, Jing
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: Oncology
subject: Head and neck
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Preoperative accurate brain tumor diagnosis plays an essential role in the selection of the optimum treatment strategy, as their management and prognosis are different. Advanced MRI techniques, such as DWI, PWI, MRS and DKI, have been wildly used to...
(100951) Sally Tombs
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Three-loop corrections to the soft anomalous dimension in multi-leg scattering
Creators: name: Almelid, Øyvind
name: Duhr, Claude
name: Gardi, Einan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present the three-loop result for the soft anomalous dimension governing long-distance singularities of multi-leg gauge-theory scattering amplitudes of massless partons. We compute all contributing webs involving semi-infinite Wilson lines at three loops and obtain the complete three-loop correction to the dipole formula. We find that non-dipole corrections appear already for three coloured partons, where the correction is a constant without kinematic dependence. Kinematic dependence appears only through conformally-invariant cross ratios for four coloured partons or more, and the result can be expressed in terms of single-valued harmonic polylogarithms of weight five. While the non-dipole three-loop term does not vanish in two-particle collinear limits, its contribution to the splitting amplitude anomalous dimension reduces to a constant, and it only depends on the colour charges of the collinear pair, thereby preserving strict collinear factorization properties. Finally we verify that our result is consistent with expectations from the Regge limit.
description: v2: remaining diagrams computed; colour conservation accounted for; strict collinear factorization shown to hold. Some references added. 6 pages, 2 figures
Additional file 5 of A trial of intra-pleural bacterial immunotherapy in malignant pleural mesothelioma (TILT) — a randomised feasibility study using the trial within a cohort (TwiC) methodology
Creators: name: Bibby, Anna C.
name: Zahan-Evans, Natalie
name: Keenan, Emma
name: Comins, Charles
name: Harvey, John E.
name: Day, Helen
name: Rahman, Najib M.
name: Fallon, Janet E.
name: Gooberman-Hill, Rachael
name: Maskell, Nick A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Additional file 5. PPI statement.
Drug Challenges Reveal Differences in Mediation of Stress Facilitation of Voluntary Alcohol Drinking and Withdrawal-Induced Anxiety in Alcohol-Preferring P Rats
Creators: name: Overstreet, David H.
name: Knapp, Darin J.
name: Breese, George R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: There is controversy over whether exposure to stress precipitates relapse and/or increases alcohol (ethanol) intake. Our laboratory has demonstrated that repeated stress prior to withdrawal from a brief forced exposure to alcohol results in withdrawal-induced anxiety-like behavior. Because anxiety is often regarded as a precipitating factor in relapsing alcoholics, we decided to examine the consequences of stressing alcohol-preferring P rats on both voluntary alcohol drinking and withdrawal-induced anxiety.
SYNTHESIS OF NEW SULFURATED DERIVATIVES OF NATURAL AND SYNTHETIC SYSTEMS AS MULTITARGET ANTICANCER AGENTS AND DEVELOPMENT OF NEW DRUG DISCOVERY METHODOLOGIES
Creators: name: GABRIELE, ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: This PhD thesis is divided in two parts. The former, entitled "Design and synthesis of new derivatives of natural and synthetic systems endowed with anticancer activity, through a multitarget mechanism", has been carried out at the Universit� degli Studi di Milano under the supervision of Professor Anna Sparatore. This project treats the synthesis of new sulfurated compounds with the aim of obtaining anticancer agents acting through a multitarget mechanism. On one hand, we explored the potentialities of new sulfurated chemical scaffolds, such as dithiolethiones, methanethiosulfonates and allyldisulfides to evaluate their antiproliferative activity, as well as their ability to inhibit STAT3 and NfkB, and to design new anticancer agents. On the other hand, we evaluated the possibility of creating hybrid molecules, combining moieties with different mechanism of action, which could carry out a synergistic antitumor effect. In particular, the sulfurated compounds synthetized have been combined with different STAT3 and/or NfkB inhibiting structures such as natural products (curcumin, phenolic acids and celastrol), semi-synthetic and synthetic systems (rosmaricine and heterocyclic compounds). Some of them exhibited very interesting inhibitory activity on both transcription factors in the micromolar range and antiproliferative activity. The second part, entitled "Optimized reaction conditions for amide bond formation in DNA-encoded combinatorial libraries", has been developed at Swiss Federal Institute of Technology in Zurich (ETH Zurich) in the research group of Professor Dario Neri. This project is focused on the advantages of using DNA-encoded chemical libraries (DECLs) in drug discovery process. In particular, since in the majority of cases DECLs require at least one-step of amide bond formation between amino modified DNA and a carboxylic acid, we optimized a new methodology of synthesis in order to facilitate the construction of single-pharmacophore libraries (DECLs).
(100952) William Hurle Clarke
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Three dental hybrid cone beam CT comparison: image quality, effective and organ doses
Creators: name: Loria, Alessandro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Head and neck
subject: Radioprotection / Radiation dose
subject: Radiation physics
subject: Cone beam CT
subject: Digital radiography
subject: Dosimetry
subject: Radiation safety
subject: Comparative studies

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Different dental CBCT are commercially available using different approaches in terms of field of view (FOV), exposure parameters and doses. Aim of this study is to provide a comparison between more widespread devices evaluating image quality and...
Linear Response Theory of Evolved Metabolic Systems
Creators: name: Yamagishi, Jumpei F.
name: Hatakeyama, Tetsuhiro S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Biological Physics (physics.bio-ph)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Predicting cellular metabolic states is a central problem in biophysics. Conventional approaches, however, sensitively depend on the microscopic details of individual metabolic systems. In this Letter, we derived a universal linear relationship between the metabolic responses against nutrient conditions and metabolic inhibition, with the aid of a microeconomic theory. The relationship holds in arbitrary metabolic systems as long as the law of mass conservation stands, as supported by extensive numerical calculations. It offers quantitative predictions without prior knowledge of systems.
description: 6+6 pages, 3+4 figures, 1 table
The Amygdala Regulates the Antianxiety Sensitization Effect of Flumazenil During Repeated Chronic Ethanol or Repeated Stress
Creators: name: Angel, Robert A.
name: Overstreet, David H.
name: Knapp, Darin J.
name: Navarro, Montserrat
name: Breese, George R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The benzodiazepine receptor antagonist flumazenil reduces anxiety-like behavior and sensitization of anxiety-like behavior in various models of ethanol withdrawal in rodents. The mechanism and brain region(s) that account for this action of flumazenil remain unknown. This investigation explored the potential role of several brain regions (amygdala, raphe, inferior colliculus, nucleus accumbens, and paraventricular hypothalamus) for these actions of flumazenil.
(100948) Elizabeth Daniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Comparison of knowledge-based iterative model reconstruction with filtered back projection in detection of small liver metastases (≤10mm) on thin-slice (1mm) non-contrast CT images
Creators: name: Yang, Lin
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Cardiac
subject: Liver
subject: CAD
subject: CT
subject: MR
subject: CAD
subject: Computer Applications-Detection, diagnosis
subject: Computer Applications-3D
subject: Cancer
subject: Cirrhosis
subject: Congenital

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: It is reported that the use of knowledge-based iterative model reconstruction (IMR) can significantly reduce image noise and improve low-contrast resolution in abdominal CT images compared with iDose4 or FBP[1-4]. The aim of the study is to compare...
(100950) John Davies
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Volume-based 3-dimensional CT breast - a new paradigm in breast imaging?
Creators: name: Yang, James
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Computer applications
subject: CT
subject: Computer Applications-3D

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast cancer is the most common cancer in women, with a lifetime risk of 1 in 8 [1]. In Singaporean women, breast cancer accounts for 29.2% of all cancers and 17.6% of all cancer deaths [2]. The current gold standard for breast cancer screening is...
Dominant couplings in qubit networks with controlled interactions
Creators: name: Maryška, Jiří
name: Novotný, Jaroslav
name: Jex, Igor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Systems evolving under the influence of competing two-body and three-body interactions, are of particular interest in exploring the stability of equilibrium states of strongly interacting many-body system. We present a solvable model based on qubit networks, which allows us to investigate the intricate influence of these couplings on the possible asymptotic equilibrium states. We study the asymptotic evolution of finite qubit networks under two and three-qubit interactions. As representatives of three-qubit interactions we choose controlled unitary interactions (cu-interactions) with one and two control qubits. It is shown that networks with purely three-qubit interactions exhibit different asymptotic dynamics depending on whether we deal with interactions controlled by one or two qubits. However, when we allow three-qubit interactions next to two-qubit interactions, the asymptotics is dictated by two-qubit interactions only. Finally, we prove that the simultaneous presence of two types of three-qubit interactions results in the asymptotic dynamics characteristic for two-qubit cu-interactions.
description: 12 pages, 9 figures
Association of ADH and ALDH Genes With Alcohol Dependence in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) Sample
Creators: name: Jiang, Cizhong
name: Sullivan, Patrick F.
name: Riley, Brien P.
name: Patterson, Diana G.
name: Alexander, Jeffry
name: Hodgkinson, Colin A.
name: Walsh, Dermot
name: Van Den Oord, Edwin J.
name: Kendler, Kenneth S.
name: Kalsi, Gursharan
name: Goldman, David
name: Kuo, Po Hsiu
name: Prescott, Carol A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The genes coding for ethanol metabolism enzymes [alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)] have been widely studied for their influence on the risk to develop alcohol dependence (AD). However, the relation between polymorphisms of these metabolism genes and AD in Caucasian subjects has not been clearly established. The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence.