cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular dynamics complemented by site-directed mutagenesis reveals significant difference between the interdomain salt bridge networks stabilizing oligopeptidases B from bacteria and protozoa in their active conformations
Creators: name: Petrenko, Dmitry E.
name: Mikhailova, Anna G.
name: Timofeev, Vladimir I.
name: Agapova, Yulia К.
name: Karlinsky, David M.
name: Komolov, Aleksandr S.
name: Korzhenevskiy, Dmitry A.
name: Vlaskina, Anna V.
name: Rumsh, Lev D.
name: Rakitina, Tatiana V.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Oligopeptidases B (OpdBs) are trypsin-like peptidases from protozoa and bacteria that belong to the prolyl oligopeptidase (POP) family. All POPs consist of C-terminal catalytic domain and N-terminal β-propeller domain and exist in two major conformations: closed (active), where the domains and residues of the catalytic triad are positioned close to each other, and open (non-active), where two domains and residues of the catalytic triad are separated. The interdomain interface, particularly, one of its salt bridges (SB1), plays a role in the transition between these two conformations. However, due to double amino acid substitution (E/R and R/Q), this functionally important SB1 is absent in γ-proteobacterial OpdBs including peptidase from Serratia proteamaculans (PSP). In this study, molecular dynamics was used to analyze inter- and intradomain interactions stabilizing PSP in the closed conformation, in which catalytic H652 is located close to other residues of the catalytic triad. The 3D models of either wild-type PSP or of mutant PSPs carrying activating mutations E125A and D649A in complexes with peptide-substrates were subjected to the analysis. The mechanism that regulates transition of H652 from active to non-active conformation upon domain separation in PSP and other γ-proteobacterial OpdB was proposed. The complex network of polar interactions within H652-loop/C-terminal α-helix and between these areas and β-propeller domain, established in silico, was in a good agreement with both previously published results on the effects of single-residue mutations and new data on the effects of the activating mutations on each other and on the low active mutant PSP-K655A. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 5887.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.08.1958, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Targeting the microRNA binding domain of argonaute 2: rational inhibitor design and study of mutation effects on protein-ligand interaction
Creators: name: Shabnam Mahernia
name: Malihe Hassanzadeh
name: Sajad Sarvari
name: Amanlou, Massoud
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Based on the accumulative evidences during recent decades, miRNAs have been found overexpressed in several human cancer types and also in Down syndrome patients, contributing to the neuropathology of Down syndrome. From this point of view, investigations on the structure and dynamic mechanisms related to the Argonaute 2 miRNAs binding in which silencing of the mRNA occurs, have inspired many clinical researchers to target this complex to inhibit the silencing process. In the current research, we have virtually screened the OTAVA_CNS_library to introduce new inhibitor compounds for the Ago2/miRNA complex. Ten hit compounds were obtained, with just one of them nominated as the best compound. Following the interaction analysis, by utilizing molecular dynamics (MD) simulations, effects of two mutations (Thr526 to isoleucine and Gln545 to alanine) on the dynamic properties of Ago2 in the complex with the best inhibitor compound were investigated. RMSD, RMSF and h-bond number beside other analyses, highlighted the importance of the Thr526 and Gln545 mutations for the stability and flexibility of the (Ago2)/ligand complex. Communicated by Ramaswamy H. Sarma
The sound-ring radiation of expanding vortex clusters
Creators: name: Geelmuyden, August
name: Erne, Sebastian
name: Patrick, Sam
name: Barenghi, Carlo
name: Weinfurtner, Silke
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We investigate wave-vortex interaction emerging from an expanding compact vortex cluster in a two-dimensional Bose-Einstein condensate. We adapt techniques developed for compact gravitational objects to derive the characteristic modes of the wave-vortex interaction perturbatively around an effective vortex flow field. We demonstrate the existence of orbits or sound-rings, in analogy to gravitational light-rings, and compute the characteristic spectrum for the out-of-equilibrium vortex cluster. The spectrum obtained from numerical simulations of a stochastic Gross-Pitaevskii equation exhibiting an expanding vortex cluster is in excellent agreement with analytical predictions. Our findings are relevant for 2d-quantum turbulence, the semi-classical limit around fluid flows, and rotating compact objects exhibiting discrete circulation.
description: 7 pages, 5 figures
Sonnenfleckenzeichnung Nr. 5909.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.09.1958, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Positional information as a universal predictor of freezing
Creators: name: Das, Tamoghna
name: Tlusty, Tsvi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Variation of positional information, measured by the two-body excess entropy $\mathsf{S}_\mathrm{2}$, is studied across the liquid-solid equilibrium transition in a simple two-dimensional system. Analysis reveals a master relation between $\mathsf{S}_\mathrm{2}$ and the freezing temperature $T_{\mathrm{f}}$, from which a scaling law is extracted: $-\mathsf{S}_\mathrm{2}\sim |T_{\mathrm{f}} - T| ^{-1/3}$. Theoretical and practical implications of the observed universality are discussed.
Molecular insight into adsorption affinities of Carmustine drug on boron and nitrogen doped functionalized single-walled carbon nanotubes using density functional theory including dispersion correction calculations and molecular dynamics simulation
Creators: name: Rabeeh Khorrampour
name: Heidar Raissi
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: Computational Biology

description: We report a quantum mechanics calculation and molecular dynamics simulation study of Carmustine drug (BNU) adsorption on the surface of nitrogen (N) and boron (B) doped-functionalized single-walled carbon nanotubes. The stability of the optimized complexes is determined on the basis of relative adsorption energy (ΔEads). The ΔEads results claim that drug molecule tends to adsorb on the nitrogen and boron doped functionalized tubes with the energy values in the range of −61.177 to −95.806 kJ/mol. Based on the obtained results, it is observed that N-doping compared with B-doping has improved more effectively drug absorption on the surface of functionalized nanotube. The results of Atoms in Molecule calculations indicate that drug adsorbs molecularly via hydrogen bonds interactions on the surface doped-functionalized carbon nanotubes. Moreover, molecular dynamics simulation is performed to investigate the dynamics behavior of the drug molecules on the nitrogen-doped functionalized carbon nanotube (f-NNT) and functionalized carbon nanotube (f-CNT). The higher average calculated electrostatic and van der Waals energies as well as higher number of intermolecular hydrogen bonds in BNU-f-NNT in comparison with BNU-f-CNT model suggest the more effectual interaction between drug molecules and nitrogen-doped functionalized carbon nanotube. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 5936.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.10.1958, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Evaluation of some genes and proteins involved in apoptosis on human chronic myeloid leukemia cells (K562 cells) by datura innoxia leaves aqueous extract
Creators: name: Chamani, Elham
name: Rezaei, Zohreh
name: Dastjerdi, Kazem
name: Javanshir, Setareh
name: Khatereh Khorsandi
name: Mohammadi, Gholam Abbas
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: Datura innoxia (D. innoxia) has an extensive usage in traditional medicine and can also be used for intervention therapy in order to treat cancer. Despite of accomplishing some researches on D. innoxia mechanism, still our knowledge is very little about exact D. innoxia apoptotic mechanism on human chronic myeloid leukemia cells (K562 cells). This study purpose was to clarify the molecular mechanism of apoptosis, which was mediated by D. innoxia leaves aqueous extract in K562 cells. MTT assay and flow cytometry was applied in order to assess the viability and apoptosis induction of K562 cells and normal human lymphoid B cells in the D. innoxia presence. Finally, the expression of the apoptotic related genes (p53, BAX, BCL2, Caspases 3, 6, 7 and 9) were evaluated using quantitative Real-Time PCR. Western blot analysis was applied for assessing the protein expression. MTT results indicated that D. innoxia could inhibit the viability of K562 cells in a dose- and time-dependent manner. In parallel, D. innoxia inhibitory effect on normal human lymphoid B cells was lower in comparison with its effect on K562 cells at the same concentrations and same incubation time. Apoptosis induction in K562 cells after D. innoxia exposure was determined by flow cytometry. Apoptosis was activated by D. innoxia in K562 cells throughout increasing the expression of P53, BAX/BCL2 ratio, caspase 9, 3, 6, 7. Western blot analysis demonstrated significant increase in cleaved PARP-1 and cleaved caspase 3 in treated K562 cells with high D. innoxia leaves aqueous extract concentration. D. innoxia leaves trigger apoptosis in K562 cells throughout intrinsic apoptotic pathway. Communicated by Ramaswamy H. Sarma
Far-from-equilibrium universality in the two-dimensional Heisenberg model
Creators: name: Rodriguez-Nieva, Joaquin F.
name: Orioli, Asier Piñeiro
name: Marino, Jamir
Publisher: name: arXiv
Year: 2021
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We characterize the universal far-from-equilibrium dynamics of the two-dimensional quantum Heisenberg magnet isolated from its environment. For a broad range of initial conditions, we find a long-lived universal prethermal regime characterized by self-similar behavior of spin-spin correlations. We analytically derive the spatial-temporal scaling exponents and find excellent agreement with numerics using phase space methods. The scaling exponents are insensitive to the choice of initial conditions, which include coherent and incoherent spin states with values of total magnetization and energy in a wide range. Compared to previously-studied self-similar dynamics in non-equilibrium $O(n)$ field theories and Bose gases, we find qualitatively distinct scaling behavior originating from the presence of spin modes which remain gapless at long times and which are protected by the global SU(2) symmetry. Our predictions, which suggest a new non-equilibrium universality class, are readily testable in ultra-cold atoms simulators of Heisenberg magnets.
description: 8+4 pages; 3+3 figures
Structural vaccinology approach to investigate the virulent and secretory proteins of Bacillus anthracis for devising anthrax next-generation vaccine
Creators: name: Gupta, Nidhi
name: Nazia Khatoon
name: Mishra, Amit
name: Verma, Vijay Kumar
name: Prajapati, Vijay Kumar
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 5929.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.10.1958, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Object solidity disambiguates ambiguous motion - exp 3b - addendum
Creators: name: Bai, Dawei
name: Strickland, Brent
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: One basic physical law of our world is “solidity”: objects do not run through each other. Is solidity embedded in the visual processing? More precisely, when viewing ambiguous motion displays, does our visual system automatically use solidity to compute motion? This is Experiments 3a, 3b and 3c of the “Object solidity disambiguates ambiguous motion” study with double ring, double stick and ball & bar displays.
Novel inhibitors of Rho-kinase mediated neuroinflammatory pathways and their potential application in recovery of injured spinal cord
Creators: name: Mallikarjuna Nimgampalle
name: Hemanth Naick Banavath
name: Harshini Chakravarthy
name: Ambrish Saxena
name: Vasudharani Devanathan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Spinal cord injury (SCI) involves damage to any part of the spinal cord which results in temporary or permanent changes in its function. Spinal cord secondary injury activates Rho-associated protein kinase 2 (ROCK2), which is involved in neuroinflammation and cell death by mediating secretion of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), interleukin-2 (IL-2), and CXC chemokines. Here we evaluated potential inhibitors of ROCK2, Caspase-1, and TNF-α from Cissus quadrangularis derived natural compounds and compared them with structural analogues of quadrangularin by molecular docking, followed by correlation using molecular dynamic simulations studies. The results clearly demonstrate that the naturally derived compounds, quadrangularin and luteolin potentially inhibit ROCK2 and Caspase-1 with high binding affinity, and showed stable conformation throughout simulation trajectory period. Interestingly, quadrangularin and its structural analogues demonstrate effective binding affinity against ROCK2, caspase-1, and TNF-α when compared to their respective known inhibitors. From our studies, we can infer that natural compounds derived from C. quadrangularis are potentially capable of inhibitory activity against ROCK2, Caspase-1, and TNF-α. These findings could help in identifying novel therapeutic drugs targeting SCI. Communicated by Ramaswamy H. Sarma
New Candidate Extreme T Subdwarfs from the Backyard Worlds: Planet 9 Citizen Science Project
Creators: name: Meisner, Aaron M.
name: Schneider, Adam C.
name: Burgasser, Adam J.
name: Marocco, Federico
name: Line, Michael R.
name: Faherty, Jacqueline K.
name: Kirkpatrick, J. Davy
name: Caselden, Dan
name: Kuchner, Marc J.
name: Gelino, Christopher R.
name: Gagne, Jonathan
name: Theissen, Christopher
name: Gerasimov, Roman
name: Aganze, Christian
name: Hsu, Chih-Chun
name: Wisniewski, John P.
name: Casewell, Sarah L.
name: Gagliuffi, Daniella C. Bardalez
name: Logsdon, Sarah E.
name: Eisenhardt, Peter R. M.
name: Allers, Katelyn
name: Debes, John H.
name: Allen, Michaela B.
name: Andersen, Nikolaj Stevnbak
name: Goodman, Sam
name: Gramaize, Leopold
name: Martin, David W.
name: Sainio, Arttu
name: Cushing, Michael C.
name: Worlds, The Backyard
name: :
name: Collaboration, Planet 9
Publisher: name: arXiv
Year: 2021
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Schneider et al. (2020) presented the discovery of WISEA J041451.67-585456.7 and WISEA J181006.18-101000.5, which appear to be the first examples of extreme T-type subdwarfs (esdTs; metallicity <= -1 dex, T_eff <= 1400 K). Here we present new discoveries and follow-up of three T-type subdwarf candidates, with an eye toward expanding the sample of such objects with very low metallicity and extraordinarily high kinematics, properties that suggest membership in the Galactic halo. Keck/NIRES near-infrared spectroscopy of WISEA J155349.96+693355.2, a fast-moving object discovered by the Backyard Worlds: Planet 9 citizen science project, confirms that it is a mid-T subdwarf. With H_W2 = 22.3 mag, WISEA J155349.96+693355.2 has the largest W2 reduced proper motion among all spectroscopically confirmed L and T subdwarfs, suggesting that it may be kinematically extreme. Nevertheless, our modeling of the WISEA J155349.96+693355.2 near-infrared spectrum indicates that its metallicity is only mildly subsolar. In analyzing the J155349.96+693355.2 spectrum, we present a new grid of low-temperature, low-metallicity model atmosphere spectra. We also present the discoveries of two new esdT candidates, CWISE J073844.52-664334.6 and CWISE J221706.28-145437.6, based on their large motions and colors similar to those of the two known esdT objects. Finding more esdT examples is a critical step toward mapping out the spectral sequence and observational properties of this newly identified population.
description: accepted for publication in ApJ; models available at https://doi.org/10.7910/DVN/SJRXUO
Sonnenfleckenzeichnung Nr. 5925.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.10.1958, erstellt von Araldo Pittini, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Sonnenfleckenzeichnung Nr. 5920.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.10.1958, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Paronella Schott 1893
Creators: name: Bellini, Bruno Cavalcante
name: Cipola, Nikolas Gioia
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Paronella

description: Genus Paronella Schött, 1893
Diagnosis. Specimens pigmented. Scales present, heavily ciliate, covering head, trunk, ventral face of manubrium and dentes. Th. III and Abd. I without mac. Antennae shorter than half body, Ant. IV not annulated or subdivided, without apical bulb. Ant. I shorter than head length. Eyes 8+8. Ungues normal, unguiculi lanceolate. Trochanteral organ well developed, with several spine-like chaetae. Collophore anterior face with 7+7 enlarged distal chaetae. Abd. II to IV bothriotricha formula as 2+2/3+3/2+2. Manubrium (Fig. 4) and dens with two rows of strong smooth dark spines; mucro short with 3–4 teeth (adapted from Mitra 1992, 1993a).
Remarks on Brazilian fauna. No nominal species of Paronella has been registered from Neotropical Region, only morphospecies (as sp.) from Mexico, Cuba, Paraguay and Brazil (Mari Mutt et al. 2016). Since Paronella is currently a restrict genus from Africa, it is quite possible that all Neotropical records are actually Trogolaphysa species (a related genus widely distributed in Neotropical Region) and at least some species present small spinelike chaetae on manubrium (see the description of T. ernesti sp. nov. and Fig. 84). The record by Bellini (2014) from Piauí State, Brazil reinforce such hypothesis since it is actually of a Trogolaphysa species with such morphology (material is insufficient to determine the species). The differential diagnosis of Paronella regarding Trogolaphysa is: presence of strong smooth conical manubrial spines (absent in Trogolaphysa) and 2+2 abdominal bothriotricha (3+ 3 in Trogolaphysa).
description: Published as part of Bellini, Bruno Cavalcante & Cipola, Nikolas Gioia, 2017, The Neotropical genera of Paronellinae (Collembola, Entomobryoidea, Paronellidae) with description of two new species and redescription of Campylothorax mitrai, pp. 151-179 in Zootaxa 4300 (2) on page 169, DOI: 10.11646/zootaxa.4300.2.1, http://zenodo.org/record/838040
A Computer Program for the Numerical Analysis of Economic Cycles Within the Framework of the Dubovsky Generalized Model
Creators: name: Makarov, Danil
name: Parovik, Roman
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: Symbolic Computation (cs.SC)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: G.1.7
subject: 37N30

description: The article proposes a computer program for calculating economic crises according to the generalized mathematical model of S.V. Dubovsky. This model is represented by a system of ordinary nonlinear differential equations with fractional derivatives in the sense of Gerasimov-Caputo with initial conditions. Furthermore, according to a numerical algorithm based on an explicit nonlocal finite-difference scheme, oscillograms and phase trajectories were constructed. It is shown that changing the orders of fractional derivatives in the model can give rise to various modes, for example, damped modes with a steady-state amplitude. It is concluded that the orders of fractional derivatives are responsible for the intensity of the process.
Jusanin, a New Flavonoid from Artemisia commutata with an In Silico Inhibitory Potential against the SARS-CoV-2 Main Protease
Creators: name: Suleimen, Yerlan
name: Jose, Rani A.
name: Suleimen, Raigul
name: Arenz, Christoph
name: Ishmuratova, Margarita
name: Toppet, Suzanne
name: Dehaen, Wim
name: Alsfouk, Bshra
name: Elkaeed, Eslam Basiouny
name: Eissa, Ibrahim
name: Metwaly, Ahmed
Publisher: name: Humboldt-Universität zu Berlin
Year: 2022
Subjects: subject: Artemisia commutata
subject: new flavonoid
subject: Jusanin
subject: COVID-19 main protease
subject: molecular similarity
subject: DFT
subject: molecular docking
subject: ADMET
subject: toxicity
subject: molecular dynamic simulations
subject: 540 Chemie und zugeordnete Wissenschaften

description: A new flavonoid, Jusanin, (1) has been isolated from the aerial parts of Artemisia commutata. The chemical structure of Jusanin has been elucidated using 1D, 2D NMR, and HR-Ms spectroscopic methods to be 5,2′,4′-trihydroxy-6,7,5′-trimethoxyflavone. Being new in nature, the inhibition potential of 1 has been estimated against SARS-CoV-2 using different in silico techniques. Firstly, molecular similarity and fingerprint studies have been conducted for Jusanin against co-crystallized ligands of eight different SARS-CoV-2 essential proteins. The studies indicated the similarity between 1 and X77, the co-crystallized ligand SARS-CoV-2 main protease (PDB ID: 6W63). To confirm the obtained results, a DFT study was carried out and indicated the similarity of (total energy, HOMO, LUMO, gap energy, and dipole moment) between 1 and X77. Accordingly, molecular docking studies of 1 against the target enzyme have been achieved and showed that 1 bonded correctly in the protein’s active site with a binding energy of −19.54 Kcal/mol. Additionally, in silico ADMET in addition to the toxicity evaluation of Jusanin against seven models have been preceded and indicated the general safety and the likeness of Jusanin to be a drug. Finally, molecular dynamics simulation studies were applied to investigate the dynamic behavior of the Mpro-Jusanin complex and confirmed the correct binding at 100 ns. In addition to 1, three other metabolites have been isolated and identified to be сapillartemisin A (2), methyl-3-[S-hydroxyprenyl]-cumarate (3), and β-sitosterol (4).
Relative, local and global dimension in complex networks
Creators: name: Peach, Robert L.
name: Arnaudon, Alexis
name: Barahona, Mauricio
Publisher: name: arXiv
Year: 2021
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Dimension is a fundamental property of objects and the space in which they are embedded. Yet ideal notions of dimension, as in Euclidean spaces, do not always translate to physical spaces, which can be constrained by boundaries and distorted by inhomogeneities, or to intrinsically discrete systems such as networks. To take into account locality, finiteness and discreteness, dynamical processes can be used to probe the space geometry and define its dimension. Here we show that each point in space can be assigned a relative dimension with respect to the source of a diffusive process, a concept that provides a scale-dependent definition for local and global dimension also applicable to networks. To showcase its application to physical systems, we demonstrate that the local dimension of structural protein graphs correlates with structural flexibility, and the relative dimension with respect to the active site uncovers regions involved in allosteric communication. In simple models of epidemics on networks, the relative dimension is predictive of the spreading capability of nodes, and identifies scales at which the graph structure is predictive of infectivity. We further apply our dimension measures to neuronal networks, economic trade, social networks, ocean flows, and to the comparison of random graphs.
Hagiografias seculares: metamorfose ou rotura?
Creators: name: Abreu, Luís Machado De
Publisher: name: Teografias
Year: 2024

description: O discurso sobre os santos e a santidade faz parte do campo semântico da religião. No Agiológio Rústico, livro publicado por Tomás da Fonseca em 1957, encontramos dez narrativas breves que traçam o perfil de homens e mulheres do mundo rural cujas vidas, simples e laboriosas, honradas e solidárias, fazem deles verdadeiros heróis do quotidiano. São os santos anónimos, dignos de verem as suas virtudes celebradas em hagiografias seculares. Com estas hagiografias, o autor não se limita a ampliar o número e a natureza dos tipos de santidade. Acima de tudo, quer subverter os pressupostos da hagiografia religiosa tradicional.
description: Teografias, n.º 3 (2013): Teografias 3: Metamorfoses da Santidade
Sonnenfleckenzeichnung Nr. 5898.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.09.1958, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Some Aspects of the Numerical Analysis of a Fractional Duffing Oscillator with a Fractional Variable Order Derivative of the Riemann-Liouville Type
Creators: name: Kim, Valentine
name: Parovik, Roman
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: Dynamical Systems (math.DS)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: G.1.7
subject: 26A33

description: In this paper, we consider some aspects of the numerical analysis of the mathematical model of fractional Duffing with a derivative of variable fractional order of the Riemann-Liouville type. Using numerical methods: an explicit finite-difference scheme based on the Grunwald-Letnikov and Adams-Bashford-Moulton approximations (predictor-corrector), the proposed numerical model is found. These methods have been verified with a test case. It is shown that the predictor-corrector method has a faster convergence than the method according to the explicit finite-difference scheme. For these schemes, using Runge's rule, estimates of the computational accuracy were made, which tended to unity with an increase in the number of calculated grid nodes.
On the R-matrix realization of quantum loop algebras
Creators: name: Liashyk, A.
name: Pakuliak, S. Z.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider $\rm R$-matrix realization of the quantum deformations of the loop algebras $\tilde{\mathfrak{g}}$ corresponding to non-exceptional affine Lie algebras of type $\hat{\mathfrak{g}}=A^{(1)}_{N-1}$, $B^{(1)}_n$, $C^{(1)}_n$, $D^{(1)}_n$, $A^{(2)}_{N-1}$. For each $U_q(\tilde{\mathfrak{g}})$ we investigate the commutation relations between Gauss coordinates of the fundamental $\mathbb{L}$-operators using embedding of the smaller algebra into bigger one. The new realization of these algebras in terms of the currents is given. The relations between all off-diagonal Gauss coordinates and certain projections from the ordered products of the currents are presented. These relations are important in applications to the quantum integrable models.
Trogolaphysa Mills 1938
Creators: name: Bellini, Bruno Cavalcante
name: Cipola, Nikolas Gioia
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Trogolaphysa

description: Genus Trogolaphysa Mills, 1938
Diagnosis. Pigmentation variable, specimens ranging from darkly pigmented to completely devoid of pigments (cave forms). Scales present, variably ciliated, covering at least Ant. I–II, dorsal and usually ventral head, dorsal trunk and ventral face of furcula; legs usually without scales. Dorsal-anterior cephalic bothriotricha present. Dorsal chaetotaxy reduced on Th. II, Th. III and Abd. I, chaetotaxy complete or almost complete in other segments, with few macrochaetae and several microchaetae. Ant. IV simple or annulated, never subdivided. 8+8 to 0+0 eyes. Labial chaeta L2 normal, never reduced. Th. II–Abd. V with ms and sens formula 10|10100 and 11|011–3, respectively. Abd. II to IV bothriotricha formula as 2+2/3+3/3+3. Manubrium lacking strong spines (at least as seen on dens), but with or without elongated thin ciliate spiniform chaetae. Dens with one or two rows of conical spines and/or elongated ciliate spiniform mac; mucro short, square or rectangular, with 3–5 teeth (adapted from Soto-Adames & Taylor 2013, Silva & Bellini 2015, Soto-Adames 2015).
Remarks on Brazilian fauna. The Brazilian species of Trogolaphysa are: T. aelleni Yoshii, 1988, T. formosensis Silva & Bellini, 2015, T. hauseri Yoshii, 1988, T. hirtipes (Handschin, 1924), T. millsi, Arlé 1939, T. tijucana (Arlé & Guimarães, 1979) and T. ernesti sp. nov. (Abrantes et al. 2012, Silva & Bellini, 2015). Most of these species present incomplete descriptions following current taxonomy of Entomobryoidea. Descriptions of ventral head, dorsal body and manubrial chaetotaxy of T. aelleni, T. hauseri, T. hirtipes, T. millsi and T. tijucana are needed to further understand such fauna. We could only compare these species with T. ernesti sp. nov. using color patterns, number of eyes, empodial and distal furcula morphology, among other few aspects.
The most dissimilar Neotropical species of Trogolaphysa is possibly T. formosensis. The species present scales on legs, enlarged Th. III and an unusual disposition of Abd. IV bothriotricha (Silva & Bellini 2015). Such characters suggest the species present a close relationship with Campylothorax (and for that, possibly Trogolaphysa as well), or even an intermediate position between both genera, hypotheses which should be tested under a phylogenetical approach.
description: Published as part of Bellini, Bruno Cavalcante & Cipola, Nikolas Gioia, 2017, The Neotropical genera of Paronellinae (Collembola, Entomobryoidea, Paronellidae) with description of two new species and redescription of Campylothorax mitrai, pp. 151-179 in Zootaxa 4300 (2) on pages 169-170, DOI: 10.11646/zootaxa.4300.2.1, http://zenodo.org/record/838040
Sonnenfleckenzeichnung Nr. 5981.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.12.1958, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
Single-chip photonic deep neural network for instantaneous image classification
Creators: name: Ashtiani, Farshid
name: Geers, Alexander J.
name: Aflatouni, Firooz
Publisher: name: arXiv
Year: 2021
Subjects: subject: Emerging Technologies (cs.ET)
subject: Optics (physics.optics)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Deep neural networks with applications from computer vision and image processing to medical diagnosis are commonly implemented using clock-based processors, where computation speed is limited by the clock frequency and the memory access time. Advances in photonic integrated circuits have enabled research in photonic computation, where, despite excellent features such as fast linear computation, no integrated photonic deep network has been demonstrated to date due to the lack of scalable nonlinear functionality and the loss of photonic devices, making scalability to a large number of layers challenging. Here we report the first integrated end-to-end photonic deep neural network (PDNN) that performs instantaneous image classification through direct processing of optical waves. Images are formed on the input pixels and optical waves are coupled into nanophotonic waveguides and processed as the light propagates through layers of neurons on-chip. Each neuron generates an optical output from input optical signals, where linear computation is performed optically and the nonlinear activation function is realised opto-electronically. The output of a laser coupled into the chip is uniformly distributed among all neurons within the network providing the same per-neuron supply light. Thus, all neurons have the same optical output range enabling scalability to deep networks with large number of layers. The PDNN chip is used for 2- and 4-class classification of handwritten letters achieving accuracies of higher than 93.7% and 90.3%, respectively, with a computation time less than one clock cycle of state-of-the-art digital computation platforms. Direct clock-less processing of optical data eliminates photo-detection, A/D conversion, and the requirement for a large memory module, enabling significantly faster and more energy-efficient neural networks for the next generations of deep learning systems.
Proteome-wide screening for designing a multi-epitope vaccine against emerging pathogen Elizabethkingia anophelis using immunoinformatic approaches
Creators: name: Zulkar Nain
name: Faruq Abdulla
name: M. Mizanur Rahman
name: Karim, Mohammad Minnatul
name: Md. Shakil Ahmed Khan
name: Sifat Bin Sayed
name: Shafi Mahmud
name: S. M. Raihan Rahman
name: Md. Moinuddin Sheam
name: Zahurul Haque
name: Adhikari, Utpal Kumar
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Elizabethkingia anophelis is an emerging human pathogen causing neonatal meningitis, catheter-associated infections and nosocomial outbreaks with high mortality rates. Besides, they are resistant to most antibiotics used in empirical therapy. In this study, therefore, we used immunoinformatic approaches to design a prophylactic peptide vaccine against E. anophelis as an alternative preventive measure. Initially, cytotoxic T-lymphocyte (CTL), helper T-lymphocyte (HTL), and linear B-lymphocyte (LBL) epitopes were predicted from the highest antigenic protein. The CTL and HTL epitopes together had a population coverage of 99.97% around the world. Eventually, six CTL, seven HTL, and two LBL epitopes were selected and used to construct a multi-epitope vaccine. The vaccine protein was found to be highly immunogenic, non-allergenic, and non-toxic. Codon adaptation and in silico cloning were performed to ensure better expression within E. coli K12 host system. The stability of the vaccine structure was also improved by disulphide bridging. In addition, molecular docking and dynamics simulation revealed strong and stable binding affinity between the vaccine and toll-like receptor 4 (TLR4) molecule. The immune simulation showed higher levels of T-cell and B-cell activities which was in coherence with actual immune response. Repeated exposure simulation resulted in higher clonal selection and faster antigen clearance. Nevertheless, experimental validation is required to ensure the immunogenic potency and safety of this vaccine to control E. anophelis infection in the future. Communicated by Ramaswamy H. Sarma
High-throughput Investigations of Topological and Nodal Superconductors
Creators: name: Tang, Feng
name: Ono, Seishiro
name: Wan, Xiangang
name: Watanabe, Haruki
Publisher: name: arXiv
Year: 2021
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The theory of symmetry indicators has enabled database searches for topological materials in normal conducting phases, which has led to several encyclopedic topological material databases. To date, such a database for topological superconductors is yet to be achieved because of the lack of information about pairing symmetries of realistic materials. In this work, sidestepping this issue, we tackle an alternative problem: the predictions of topological and nodal superconductivity in materials for each single-valued representation of point groups. Based on recently developed symmetry indicators for superconductors, we provide comprehensive mappings from pairing symmetries to topological or nodal superconducting nature for nonmagnetic materials listed in Inorganic Crystal Structure Database. We quantitatively show that around 90\% of computed materials are topological or nodal superconductors when a pairing that belongs to a one-dimensional nontrivial irrep of point groups is assumed. When materials are representation-enforced nodal superconductors, positions and shapes of the nodes are also identified. These data are aggregated at \textit{Database of Topological and Nodal Supercoductors}. We also provide a subroutine \textit{Topological Supercon}, which allows users to examine the topological nature in the superconducting phase of any material themselves by uploading the result of first-principles calculations as an input. Our database and subroutine, when combined with experiments, will help us understand the pairing mechanism and facilitate realizations of the long-sought Majorana fermions promising for topological quantum computations.
description: 7 pages. See "Ancillary files" for Supplemental Materials. Update the database to include pairings of multi-dimensional irreps
Sonnenfleckenzeichnung Nr. 5976.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.12.1958, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1958

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf dem Vordruck der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert
description: ETH-Bibliothek
A sagração da luxúria, segundo Raul Leal
Creators: name: Silva, Manuela Parreira Da
Publisher: name: Teografias
Year: 2024

description: Para Raul Leal, o sacrifício do corpo e a luxúria são duas formas vertígicas e complementares de libertar o Espírito, vivenciando Deus-Satã. Este é o desígnio humano, assente na ideia de que a Imensidade (Deus) existe em cada um de nós, do mesmo modo que cada um de nós existe na Imensidade (em Deus).
description: Teografias, n.º 3 (2013): Teografias 3: Metamorfoses da Santidade
São Paulo, “Poeta da Loucura”, na visão de Teixeira de Pascoaes
Creators: name: Santos, Margarida
Publisher: name: Teografias
Year: 2024

description: Afirma Pascoaes que o pecado e o remorso são mais fecundos do que a virtude e é a partir desta convicção que ele constrói a biografia do jovem judeu Paulo de Tarso, implacável perseguidor dos cristãos, que, na sequência da morte de Estêvão, primeiro mártir, teve uma visão na qual Deus o interpelava. Convertendo-se, tornou-se no apóstolo Paulo, o divino Poeta da Loucura, na expressão de Pascoaes e, com a mesma loucura apaixonada com que antes O combatia, passou a defender Cristo e a levar a Sua palavra a judeus e pagãos, vencendo cansaços, humilhações, maus tratos e a prisão, até sofrer ele próprio o martírio. Na primeira Epístola aos Coríntios, Paulo recomenda: “se algum de entre vós se julga sábio à maneira deste mundo, torne-se louco para ser sábio” (1 Cor 3, 16-23).
description: Teografias, n.º 3 (2013): Teografias 3: Metamorfoses da Santidade