Additional file 1 of Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
Creators: name: Katrinli, Seyma
name: Wani, Agaz H.
name: Maihofer, Adam X.
name: Ratanatharathorn, Andrew
name: Daskalakis, Nikolaos P.
name: Montalvo-Ortiz, Janitza
name: Núñez-Ríos, Diana L.
name: Zannas, Anthony S.
name: Zhao, Xiang
name: Aiello, Allison E.
name: Ashley-Koch, Allison E.
name: Avetyan, Diana
name: Baker, Dewleen G.
name: Beckham, Jean C.
name: Boks, Marco P.
name: Brick, Leslie A.
name: Bromet, Evelyn
name: Champagne, Frances A.
name: Chen, Chia-Yen
name: Dalvie, Shareefa
name: Dennis, Michelle F.
name: Fatumo, Segun
name: Fortier, Catherine
name: Galea, Sandro
name: Garrett, Melanie E.
name: Geuze, Elbert
name: Grant, Gerald
name: Hauser, Michael A.
name: Hayes, Jasmeet P.
name: Hemmings, Sian M. J.
name: Huber, Bertrand Russel
name: Jajoo, Aarti
name: Jansen, Stefan
name: Kessler, Ronald C.
name: Kimbrel, Nathan A.
name: King, Anthony P.
name: Kleinman, Joel E.
name: Koen, Nastassja
name: Koenen, Karestan C.
name: Kuan, Pei-Fen
name: Liberzon, Israel
name: Linnstaedt, Sarah D.
name: Lori, Adriana
name: Luft, Benjamin J.
name: Luykx, Jurjen J.
name: Marx, Christine E.
name: McLean, Samuel A.
name: Mehta, Divya
name: Milberg, William
name: Miller, Mark W.
name: Mufford, Mary S.
name: Musanabaganwa, Clarisse
name: Mutabaruka, Jean
name: Mutesa, Leon
name: Nemeroff, Charles B.
name: Nugent, Nicole R.
name: Orcutt, Holly K.
name: Qin, Xue-Jun
name: Rauch, Sheila A. M.
name: Ressler, Kerry J.
name: Risbrough, Victoria B.
name: Rutembesa, Eugène
name: Rutten, Bart P. F.
name: Seedat, Soraya
name: Stein, Dan J.
name: Stein, Murray B.
name: Toikumo, Sylvanus
name: Ursano, Robert J.
name: Uwineza, Annette
name: Verfaellie, Mieke H.
name: Vermetten, Eric
name: Vinkers, Christiaan H.
name: Ware, Erin B.
name: Wildman, Derek E.
name: Wolf, Erika J.
name: Young, Ross McD
name: Zhao, Ying
name: van den Heuvel, Leigh L.
name: Uddin, Monica
name: Nievergelt, Caroline M.
name: Smith, Alicia K.
name: Logue, Mark W.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. PTSD-associated CpGs from the primary analysis in the sensitivity analysis adjusted for smoking score. Table S2. DNA methylation and cis-gene expression (RNAseq) correlations. Table S3. Correlation values of methylation between blood and brain regions from Blood Brain DNA Methylation Comparison Tool. Table S4. Results of PTSD-associated CpGs from blood in fibroblasts. Table S5. Significant SNPs from cis-meQTL analysis and their association with PTSD. Table S6. Genetic associations of the identified PTSD-associated genes from gene-based tests. Table S7. Results of hypergeometric tests in postmortem brain tissues. Table S8. Results of PTSD-associated CpGs from blood in the brain. Table S9. Results of PTSD-associated CpGs from blood in neuronal nuclei. Table S10. PTSD-associated CpGs from the primary analysis in the stratified analysis for sex, ancestry, and trauma type. Table S11. Gene Ontology Enrichment results in females. Fig S1. Forest Plots of PTSD-associated CpGs in each cohort. Fig S2. Manhattan plots of the stratified analyses. Fig S3. Correlation of effect sizes based on stratified analyses for ancestry and sex. Fig S4. Forest Plots of CpGs associated with PTSD in the stratified analysis for females. Fig S5. Forest Plots of CpGs associated with PTSD in the stratified analysis for males. Fig S6. Forest Plots of CpGs associated with PTSD in the stratified analysis for European ancestry. Fig S7. Forest Plots of CpGs associated with PTSD in the stratified analysis for African ancestry. Fig S8. Forest Plots of CpGs associated with PTSD in the stratified analysis for civilian trauma. Fig S9. Forest Plots of CpGs associated with PTSD in the stratified analysis for military trauma.