cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of in vitro Models for Delivery of the Anti-Viral Drug Acyclovir for Ocular HSV-I Infection Treatment
Creators: name: Bareiss, Bettina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biology, Molecular.

description: Herpes simplex virus 1 (HSV-1) infection is the main cause of vision loss in the developed world due to the fact that after initial infection, the virus establishes latency and can be reactivated; resulting in a very low success rate of treatment by transplantation (22%). We are developing corneal substitutes suitable for HSV-1 transplantation by incorporating anti-viral drugs such as acyclovir (ACV), into corneal substitutes that could potentially suppress the viral reactivation. Specifically, we examined the feasibility of preventing viral reactivation during surgery, by sustained delivery of ACV introduced during corneal transplantation surgery, through encapsulation of the drug within silica (SiO2) nanoparticles (NP) incorporated into biosynthetic alternatives to donor corneas. We show that incorporation of NPs did not affect optical clarity of the collagen-based corneal substitutes nor their biocompatibility. NP-encapsulation effectively sustained ACV release from the biosynthetic implants over 10 days, compared to free ACV incorporated directly into the hydrogel constructs. The NP-enabled sustained release resulted in effective prevention of virally-induced cell death, not observed with the free drug. This early model demonstrates the feasibility of using biomimetic corneal substitutes that incorporate a drug release system (e.g. silica nanoparticles encapsulating ACV) as future alternatives to human donor tissue grafts, for transplantation of HSV-infected corneas.
La participation des mouvements sociaux dans le système pénal: L'affaire Latimer
Creators: name: Lachambre, Sébastien
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Sociology, Criminology and Penology.

description: Dans cette recherche, nous explorons la participation des mouvements sociaux dans le systeme pénal. Nous voulons décrire l'échange de communications entre les mouvements sociaux et les tribunaux, dans l'affaire Latimer. Il s'agit de voir si ces mouvements sociaux mobilisent et actualisent ou non, dans leurs communications, les idées et les théories du système pénal, et d'explorer la réception de ces communications par les tribunaux. Notre recherche, qualitative, est une analyse documentaire et elle s'appuie sur deux axes théoriques: l'étude de la rationalité pénale moderne et un modèle alternatif d'observation des mouvements sociaux qui se fonde sur la théorie des systèmes sociaux de Luhmann. Nous avons déterminé que les intervenants dans l'affaire Latimer semblent avoir actualisé les principaux éléments constitutifs de la rationalité pénale moderne et nous avons observé l'autonomie des tribunaux face aux influences qu'ils subissent lorsque vient le temps de rendre une décision.
Supplementary document for Cr:ZnSe mid-IR, multi-mJ, few-cycle amplifier: a new platform for attosecond soft-X-ray physics - 4647502.pdf
Creators: name: Leshchenko, Vyacheslav
name: Talbert, Bradford Kent
name: Lai, Yu Hang
name: Li, Sha
name: Tang, Yaguo
name: Hageman, Stephen J.
name: Smith, Greg J.
name: Agostini, Pierre
name: DiMauro, Louis
name: Blaga, Cosmin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: additional technical details on the performed simulations and experiments
Hearing Screening Failure in Reading Impairment (Werfel et al., 2020)
Creators: name: Werfel, Krystal
name: Peek, Laura
name: Reynolds, Gabriella
name: Bassard, Sydney
Publisher: name: ASHA journals
Year: 2020
Subjects: subject: 200101 Communication Studies
subject: FOS: Media and communications

description: Background: The purpose of this preliminary study was to explore one potential underlying factor that may contribute to poor reading outcomes: minimal hearing loss. Additionally, we compared decoding and comprehension deficits in students who passed or failed the hearing screening.
Method: Forty-three school-age students completed a hearing screening and a literacy assessment.
Results: Fifty-four percent of children with reading impairments failed the hearing screening, compared to only 21% of children with typical reading. Additionally, students who failed the hearing screening were more likely to exhibit decoding deficits; comprehension skills between the hearing screening groups did not differ.
Conclusions: Thus, children with reading impairments are more likely to fail hearing screenings than children with typical reading, and the deficits of those who fail hearing screenings appear to center on decoding rather than comprehension skills.
Supplemental Material S1. Pattern of hearing screening fails across participants.

Werfel, K. L., Peek, L., Reynolds, G., Bassard, S. (2020). Hearing screening failure among students with reading impairment: Rate and Relation to specific reading deficits. Perspectives of the ASHA Special Interest Groups. Advance online publication. https://doi.org/10.1044/2020_PERSP-19-00163
Uncoiling the mysteries of DivIVA(Ef): The biological functioning of the Enterococcus faecalis cell development protein
Creators: name: Marthaler, Susan J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Microbiology.

description: Cell division mechanisms involving native proteins MinCDE or MinCD and DivIVA have been explored using Esherichia coli (Ec) and Bacillus subtilis (Bs), respectively. My research examines the Gram-positive coccal-shaped Enterococcus faecalis (Ef) protein DivIVA, which functions without any Min proteins. To determine whether E. coli could be used as a suitable indicator system, DivIVAEf overexpression and morphological studies were undertaken. Constructs with unique mutations created along the 699-nucleotide length of the divIVAEf gene to abrogate specific coiled-coil domains at the N-terminal, C-terminal and two central regions were investigated in this model. The original mutations were previously used in different systems and therefore required PCR amplification, double digest with new restriction enzymes prior to subcloning in pUC18 for transformation in E. coli (Ramirez-Arcos et al., 2005; Rigden et al., 2005). (Abstract shortened by UMI.)
Investigation of two widely used nanomaterials (TiO2, Ag) for ecotoxicological long-term effects - adaption of test guidelines
Creators: name: Schäfer, Christoph
name: Weil, Mirco
Publisher: name: My University
Year: 2013
Subjects: subject: Prüfverfahren
subject: Nanomaterialien
subject: Langzeitwirkung
subject: Wasserorganismen
subject: Silber
subject: Sediment
subject: Standardmethode
subject: Titandioxid
subject: Nanosilber
subject: Ökotoxikologische Bewertung
subject: nanomaterials
subject: long-term effect
subject: test process
subject: titanium dioxide
subject: silver
subject: ecotoxicological assessment
subject: Chemikalien
subject: Chemicals

description: The nanoparticulate titanium dioxide NM-105 was investigated in two tests with Lumbriculus variegatus in a sediment-water system according to the ⁠OECD⁠ TG 225 [5]. The nominal test concentrations in the first test were 15; 23; 39; 63 and 100 mg/L NM-105 and 100 mg/L NM-105 in the second test. Chemical analysis of titanium concentrations in test media in the first test showed good agreement with nominal test concentrations.
Zločin iz mržnje prema pripadnicima srpske nacionalne manjine – Priručnik za žrtve
Creators: name: Čalić Jelić, Milena
name: Dabić, Tea
Publisher: name: Kuća ljudskih prava Zagreb
Year: 2021
Subjects: zločin iz mržnje
Srbi

description: Priručnik daje odgovor na pitanja što je zločin iz mržnje, kome i kako ga prijaviti, koja prava pripadaju žrtvama zločina iz mržnje te koje vrste zaštite stoje na raspolaganju žrtvama zločina iz mržnje u odnosu na njihov specifičan položaj. Priručnik stavlja naglasak na specifičan položaj pripadnika srpske nacionalne manjine, a namijenjen je osobama koje su same bile metom zločina iz mržnje ili su svjedočile zločinu iz mržnje, kao i stručnim djelatnicima, organizacijama civilnog društva i svim drugim dionicima koji rade ili se u okviru svog djelovanja susreću sa žrtvama zločina iz mržnje.
Model-Based Therapy Planning Allows Prediction of Haemodynamic Outcome after Aortic Valve Replacement
Creators: name: Kelm, M.
name: Goubergrits, L.
name: Bruening, J.
name: Yevtushenko, P.
name: Fernandes, J. F.
name: Sündermann, S. H.
name: Berger, F.
name: , Falk
name: Kuehne, T.
name: Nordmeyer, S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Experimental models of disease
subject: Translational research
subject: Valvular disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Optimizing treatment planning is essential for advances in patient care and outcomes. Precisely tailored therapy for each patient remains a yearned-for goal. Cardiovascular modelling has the potential to simulate and predict the functional response before the actual intervention is performed. The objective of this study was to proof the validity of model-based prediction of haemodynamic outcome after aortic valve replacement. In a prospective study design virtual (model-based) treatment of the valve and the surrounding vasculature were performed alongside the actual surgical procedure (control group). The resulting predictions of anatomic and haemodynamic outcome based on information from magnetic resonance imaging before the procedure were compared to post-operative imaging assessment of the surgical control group in ten patients. Predicted vs. post-operative peak velocities across the valve were comparable (2.97 ± 1.12 vs. 2.68 ± 0.67 m/s; p = 0.362). In wall shear stress (17.3 ± 12.3 Pa vs. 16.7 ± 16.84 Pa; p = 0.803) and secondary flow degree (0.44 ± 0.32 vs. 0.49 ± 0.23; p = 0.277) significant linear correlations (p
Perceptions of the family physician from adolescents and their caregivers preparing to transition to adult care
Creators: name: Han, Angela X.
name: Whitehouse, Sandy R.
name: Tsai, Steve
name: Hwang, Sandy
name: Thorne, Sally E. (Sally Elizabeth), 1951-
Publisher: name: BioMed Central
Year: 2018

description: Background: Adolescents with chronic health conditions and/or disabilities (CHC/D’s) often face challenges when transitioning to adult care, which leads to a higher risk of morbidity and mortality. Although it is recommended that establishing the medical home and family physician (FP) attachment prior to transfer will improve health outcomes, there is little evidence or policy surrounding the role of the FP during this transition. This study explores the described use of health services by adolescents with CHC/D’s, as well as the adolescent’s and caregiver’s perceptions of their FP. Methods: Participants were recruited from the British Columbia Children’s Hospital, Canada and a multi-method phased approach was used. In Phase 1, 84 adolescent and caregiver pairs completed questionnaires asking what medical services they accessed for specific health needs. In Phase 2, another cohort of 21 adolescent and caregiver pairs completed the same questionnaires and were interviewed regarding their perception of their FP. Results: 96% (n = 81) of adolescents with CHC/D’s in phase 1 had a FP. Thirty four percent (n = 34) of adolescents had not seen their FP in the last 6 months. While adolescents with CHC/D mostly accessed their FP for primary health issues, they frequently also accessed specialists for prescription refills (50%, n = 51), mental health (29%, n = 30) and sexual health (16%, n = 16). While most adolescent/caregiver participants reported positive communication and trust in their FP, some had a poor understanding of the FP’s role in coordinating care. Conclusion: As many adolescents with CHC/D may see their FP infrequently and may not clearly understand their role, opportunities exist for strengthening primary care home attachment as well as adolescent and caregiver literacy around the potential contribution of the FP during and after transfer to adult services. Responsibility for improving care coordination for this population should be ideally shared between FPs and pediatric specialists.
Evaluation of Insulin and Vanillylmandelic concentrations in hypertensive subjects undergoing care at Federal Teaching Hospital, Owerri
Creators: name: Nwanguma E.D
name: Nwanjo H.
name: Nwosu D.
name: Ude U.A
name: Nnodim J.
name: Edward U.
Publisher: name: gjrpublication
Year: 2024

description: A Cross-Sectional study to evaluate the levels of insulin and vanillylmandelic acid in hypertensives attending clinic at Federal University Teaching Hospital, Owerri was carried out. A total of subjects comprising 104 hypertensives (54 males, 50 females) on treatment, 52 hypertensives not on treatment and 52 normotensives who served as control and within the ages of 25 and 72 years were recruited for the study. The serum obtained was used for the determination of insulin and vanillylmandelic acid using Enzyme linked immunosorbent assay techniques. All kits were commercially purchased and the manufacturer’s standard operational procedures were strictly followed. Data was analyzed using the software statistical package for social sciences version 21, windows 9, values were expressed as mean ± standard deviation, student t-test and analysis of variance were used to analyze the difference in experimental variables. There were significant lower levels of insulin and vanillylmandelic acid in hypertensive on treatment compared to hypertensive not on treatment From the findings, the inclusion of insulin and vanillylmandelic acid in the routine laboratory investigations of conditions related to obesity, myocardial infarction, coronary heart disease, artherosclerotic disease, dyslipidaemia, vascular hypertrophy and other complications of hypertension in these patients will be useful in the prediction, management and risk assessment of this disease and may subsequently improve treatment outcome.
Effects of agroforestry on grain yield of maize (Zea mays L.) - A global meta-analysis
Creators: name: Baier, Clara
name: Gross, Arthur
name: Thevs, Niels
name: Glaser, Bruno
Publisher: name: My University
Year: 2023
Subjects: Agroforstwirtschaft
Mais

description: Maize cropping systems, the world's most important cropping systems in terms of production volume, are responsible for many environmental problems, such as soil degradation and erosion. This calls for sustainable practises that enable environment-friendly production while generating sufficient output, as farmers and consumers worldwide depend on adequate yields. Agroforestry can offer solutions to both of these pressing concerns - food insecurity and adverse environmental impacts of intensive maize cultivation. This meta-analysis investigated the effects of agroforestry on maize (Zea mays L.) grain yield under different environmental and management regimes on a global scale. It is based on 1,215 pairwise data entries from 95 peer-reviewed studies. Overall, agroforestry increased median maize yields by 0.24 Mg ha^-1 (7%) compared to tree/hedgerow-free maize monocultures. In subtropical and tropical regions, the median yield increment under agroforestry was 0.30 Mg ha^-1 (+16%), and the best results were achieved using broadleaved trees (+0.42 Mg ha^-1, +53%), especially N-fixing tree species (+0.56 Mg ha^-1, +60%). Maize yields responded very well to the addition of tree prunings to the soil of the maize crop (+0.48 Mg ha^-1, +24%). Rotating maize with other crops was beneficial if the intermediate crop is able to fix atmospheric N (+0.28 Mg ha^-1, +13%). We found that hedgerow planting densities of at least 5,000 woody perennials ha^-1 are required for the positive impacts of agroforestry on maize yields to take effect, and these effects increased with both tree age (+1.17 Mg ha^-1, +48% under trees 11-15 years of age) and time under agroforestry (+0.85 Mg ha^-1, 81% in response to >15 continuous maize seasons under agroforestry). In addition, they were particularly pronounced on sandy soils (+0.46 Mg ha^-1, +23%), moderately acidic soils of pH 5-6 (+0.67 Mg ha^-1, +35%), soils with <0.5 g kg^-1 N (+1.19 Mg ha^-1, +81%), soils with a plant-available water holding capacity <10 mm dm^-1 (+1.10 Mg ha^-1, +44%), and hyper-arid conditions (+0.60 Mg ha^-1, +35%). These findings prove that if designed with due regard for local conditions and crop/tree species characteristics, agroforestry can be a powerful tool to increase food security and the sustainability of maize production systems. © 2023 Baier, Gross, Thevs and Glaser
Different Achilles Tendon Pathologies Show Distinct Histological and Molecular Characteristics
Creators: name: Klatte-Schulz, Franka
name: Minkwitz, Susann
name: Schmock, Aysha
name: Bormann, Nicole
name: Kurtoglu, Alper
name: Tsitsilonis, Serafeim
name: Manegold, Sebastian
name: Wildemann, Britt
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: acute rupture
subject: chronic tendon pathologies
subject: fat
subject: human
subject: inflammation
subject: innervation
subject: matrix
subject: modeling/remodeling
subject: tendon structure
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Reasons for the development of chronic tendon pathologies are still under debate and more basic knowledge is needed about the different diseases. The aim of the present study was therefore to characterize different acute and chronic Achilles tendon disorders. Achilles tendon samples from patients with chronic tendinopathy (n = 7), chronic ruptures (n = 6), acute ruptures (n = 13), and intact tendons (n = 4) were analyzed. The histological score investigating pathological changes was significantly increased in tendinopathy and chronic ruptures compared to acute ruptures. Inflammatory infiltration was detected by immunohistochemistry in all tendon pathology groups, but was significantly lower in tendinopathy compared to chronic ruptures. Quantitative real-time PCR (qRT-PCR) analysis revealed significantly altered expression of genes related to collagens and matrix modeling/remodeling (matrix metalloproteinases, tissue inhibitors of metalloproteinases) in tendinopathy and chronic ruptures compared to intact tendons and/or acute ruptures. In all three tendon pathology groups markers of inflammation (interleukin (IL) 1beta, tumor necrosis factor alpha, IL6, IL10, IL33, soluble ST2, transforming growth factor beta1, cyclooxygenase 2), inflammatory cells (cluster of differentaition (CD) 3, CD68, CD80, CD206), fat metabolism (fatty acid binding protein 4, peroxisome proliferator-activated receptor gamma, CCAAT/enhancer- binding protein alpha, adiponectin), and innervation (protein gene product 9.5, growth associated protein 43, macrophage migration inhibitory factor) were detectable, but only in acute ruptures significantly regulated compared to intact tendons. The study gives an insight into structural and molecular changes of pathological processes in tendons and might be used to identify targets for future therapy of tendon pathologies.
Die weltweite Ausbreitung von Bettwanzen stellt auch in Deutschland ein Problem dar
Creators: name: Pan, Arlette Vander
Publisher: name: My University
Year: 2014
Subjects: Bettwanze

description: Weltweit mehren sich die Berichte über die Ausbreitung der Bettwanzen Cimex lectulariusund C. hemipterus(in Australien). Unabhängig von den hygienischen Bedingungen sind die Insekten insbesondere in Hotels und Hostels sowie in anderen Ferienunterkünften, Gesundheitseinrichtungen, Transportmitteln und im Gebrauchtwarenhandel zu finden und breiten sich von dort in Privathaushalte aus. Ein Bettwanzenbefall kann durchaus gesundheitliche Auswirkungen haben und stellt für die Betroffenen eine starke Belastung dar. Bei der weltweiten Ausbreitung der Insekten scheint es sich um ein multifaktorielles Geschehen zu handeln, dessen Ursachen kontrovers diskutiert werden. Diese werden u. a. in einer Zunahme der internationalen Reisetätigkeit und des Gebrauchtwarenhandels gesucht. Eine entscheidende Rolle könnten die eingeschränkte Verfügbarkeit wirksamer Insektizide mit Langzeitwirkung und die Entwicklung von Resistenzen gegen die verfügbaren Wirkstoffe spielen. Mangels offizieller Daten ist eine Quantifizierung des Auftretens von Bettwanzen in Deutschland nicht möglich, aber Schädlingsbekämpfer und öffentliche Behörden berichten von zunehmenden Fallzahlen und Problemen bei der Bekämpfung. Letztere scheinen hier - wie auch in anderen Ländern - u. a. durch die Ausbildung von Wirkstoffresistenzen (insbesondere Pyrethroide) bedingt zu sein. Vor diesem Hintergrund ist die Prävention und damit die Aufklärung der Bevölkerung über die Lebensweise und Ausbreitungswege der Insekten von entscheidender Bedeutung, um ihrer Ausbreitung entgegenwirken zu können.
© www.link.springer.com
D2.1 Stakeholders' board structure, communication tools and rules
Creators: name: Claudia Iasillo
Publisher: name: Zenodo
Year: 2022
Subjects: Stakeholders engagement
Blue Bioeconomy
Local communities

description: The current document, titled Stakeholders' board structure, communication tools and rules, has been developed within the framework of the BlueRev project which is funded by the European Union’s Horizon Europe Research and Innovation Programme under Grant Agreement No 101060537.

The document contains the description of the set-up procedures of BlueRev Stakeholders’ Board (SB). The set-up of the SB is foreseen by M3 (November 2022) as basis for BlueRev stakeholder engagement activities rooted in the whole project since its early phases.

The main activities of the SB will include providing input on governance, business models and social innovation at regional and local scale; participation in workshops; evaluation of Governance/business models/KPIs/models for social innovations developed within the project.

This document provides an overview of the role of the SB within the project and how the engagement of stakeholders will contribute to project objectives and impacts. Both the structure of the board and how it will be used in the project, in compliance with General Data Protection Regulation (GDPR), are described in the first sections of this report.
Thymic epithelial cell alterations and defective thymopoiesis lead to central and peripheral tolerance perturbation in MHCII deficiency
Creators: name: Ferrua, Francesca
name: Bortolomai, Ileana
name: Fontana, Elena
name: Di Silvestre, Dario
name: Rigoni, Rosita
name: Marcovecchio, Genni Enza
name: Draghici, Elena
name: Brambilla, Francesca
name: Castiello, Maria Carmina
name: Delfanti, Gloria
name: Moshous, Despina
name: Picard, Capucine
name: Taghon, Tom
name: Bordon, Victoria
name: Schulz, Ansgar S.
name: Schuetz, Catharina
name: Giliani, Silvia
name: Soresina, Annarosa
name: Gennery, Andrew R.
name: Signa, Sara
name: Dávila Saldaña, Blachy J.
name: Delmonte, Ottavia M.
name: Notarangelo, Luigi D.
name: Roifman, Chaim M.
name: Poliani, Pietro Luigi
name: Uva, Paolo
name: Mauri, Pier Luigi
name: Villa, Anna
name: Bosticardo, Marita
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: thymus
subject: thymic epithelial cells
subject: primary immunodeficiency
subject: MHCII
subject: central tolerance
subject: DDC 610 / Medicine & health
subject: Severe combined immunodeficiency
subject: Thymus gland
subject: Epithelial cells
subject: Major histocompatibility complex
subject: MHC
subject: Immundefekt

description: Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules. MHCII deficiency results in impaired cellular and humoral immune responses, leading to severe infections and autoimmunity. Abnormal cross-talk with developing T cells due to the absence of MHCII expression likely leads to defects in thymic epithelial cells (TEC). However, the contribution of TEC alterations to the pathogenesis of this primary immunodeficiency has not been well characterized to date, in particular in regard to immune dysregulation. To this aim, we have performed an in-depth cellular and molecular characterization of TEC in this disease. We observed an overall perturbation of thymic structure and function in both MHCII−/− mice and patients. Transcriptomic and proteomic profiling of murine TEC revealed several alterations. In particular, we demonstrated that impairment of lymphostromal cross-talk in the thymus of MHCII−/− mice affects mTEC maturation and promiscuous gene expression and causes defects of central tolerance. Furthermore, we observed peripheral tolerance impairment, likely due to defective Treg cell generation and/or function and B cell tolerance breakdown. Overall, our findings reveal disease-specific TEC defects resulting in perturbation of central tolerance and limiting the potential benefits of hematopoietic stem cell transplantation in MHCII deficiency.
Investigating grain growth in disks around southern T Tauri stars at millimetre wavelengths
Creators: name: Lommen, D.
name: Wright, C. M.
name: Maddison, Sarah
name: Jørgensen, J. K.
name: Bourke, T. L.
name: Van Dishoeck, E. F.
name: Hughes, A.
name: Wilner, D. J.
name: Burton, M.
name: Van Langevelde, H. J.
Publisher: name: Swinburne
Year: 2024

description: CONTEXT - Low-mass stars form with disks in which the coagulation of grains may eventually lead to the formation of planets. It is not known when and where grain growth occurs, as models that explain the observations are often degenerate. A way to break this degeneracy is to resolve the sources under study. AIMS - To find evidence for the existence of grains of millimetre sizes in disks around in T Tauri stars, implying grain growth. METHODS - The Australia Telescope Compact Array (ATCA) was used to observe 15 southern T Tauri stars, five in the constellation Lupus and ten in Chamaeleon, at 3.3 millimetre. The five Lupus sources were also observed with the Submillimeter Array (SMA) at 1.4 millimetre. Our new data are complemented with data from the literature to determine the slopes of the spectral energy distributions in the millimetre regime. RESULTS - Ten sources were detected at better than 3sigma with the ATCA, with sigma ~1-2 mJy, and all sources that were observed with the SMA were detected at better than 15sigma, with sigma ~4 mJy. Six of the sources in our sample are resolved to physical radii of ~100 AU. Assuming that the emission from such large disks is predominantly optically thin, the millimetre slope can be related directly to the opacity index. For the other sources, the opacity indices are lower limits. Four out of six resolved sources have opacity indices <~1, indicating grain growth to millimetre sizes and larger. The masses of the disks range from < 0.01 to 0.08 MSun, which is comparable to the minimum mass solar nebula. A tentative correlation is found between the millimetre slope and the strength and shape of the 10-micron silicate feature, indicating that grain growth occurs on similar (short) timescales in both the inner and outer disk.
title: Checklisten für die Untersuchung und Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen
title: Anlagenbezogener Gewässerschutz: Übersicht
titleType: AlternativeTitle
Creators: name: Winkelmann-Oei, Gerhard
name: Platkowski, Jörg
Publisher: name: My University
Year: 2016
Subjects: subject: Gewässerschutz
subject: Risikomanagement
subject: Leitfaden
subject: anlagenbezogen
subject: Wasserverschmutzung
subject: Wasserschadstoffe
subject: Checkliste
subject: Chemikalien
subject: Chemicals

description: Basierend auf den Empfehlungen der internationalen Flussgebiets- und Gewässerkommissionen wurde ein Checklisten-Konzept entwickelt, welches eine effiziente Beurteilung des Zustandes von Anlagen mit wassergefährdenden Stoffen und Zubereitungen ermöglicht. Es enthält eine Übersicht  über potentielle Handlungsfelder sowie spezielle Checklisten, welche nach Funktionseinheiten, Branchen und Risikobereichen aufgeteilt sind.
Understanding the Role of Graphic Design in Communication Campaigns: An Indonesian Case Study
Creators: name: Suhendra, Fanny
Publisher: name: Swinburne
Year: 2024

description: Through the provision of two Indonesian case studies: Revolusi Mental and Jokowi-Tintin, The thesis makes an original contribution to the fields of graphic design, social marketing, health promotion and political advertising by examining the presence and operation of graphic design within its campaigns, revealing graphic design to be a formative element of a campaign rather than simply playing an ancillary role. The thesis shows how the increasing presence of audience-generated content in the Jokowi-Tintin campaign highlights the potential of graphic design to drive the evolution of a campaign system to the extent where creative agency is shared between campaign creators and audience members.
Supplementary document for Tunable SIM: observation at varying spatiotemporal resolutions across the FOV - 4650567.pdf
Creators: name: WOO, TAESEONG
name: Jeong, Soohyun
name: ahn, cheolwoo
name: Hwang, Byungjae
name: kim, hyunggee
name: Kang, JooHun
name: Park, Jung-Hoon
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplementary Material
Self-assembled quantum dot semiconductor nanostructures modeling: Photonic device applications
Creators: name: Benhsaien, Abdessamad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: A microscopic analysis of a vertical stack of self-assembled InAs/GaAs lens-shaped quantum dot nanostructures is presented. The analysis revolves around a rigorous Hamiltonian formulation of an eight-band k.p. perturbation to account for the lattice-mismatch strain endured by the islands. The numerical implementation yields the effective bandgap energy and electronic structure of an InAs/GaAs quantum dot. Within the framework of a resonant two-level energy system, material gain and absorption spectra are calculated up to a third-order susceptibility to include nonlinearity. The material gain polarization dependence is expressed in the dipole transition strength. Polarization-dependent anisotropy factors corresponding to different interband transitions are derived and shown to satisfy a momentum conservation rule. Modal analysis of a rectangular core waveguide realized by imbedding the active quantum dot layer(s) into a cladding medium with lower refractive index is presented. Polarization-independent modal gain is achieved by optimizing the width of the rectangular core waveguide. In illustration of a quantum dot device, a realistic semiconductor optical amplifier model accounting for both stimulated and spontaneous emission is considered. The calculated carrier density longitudinal profile yields other parameters characterizing the amplifier performance.
Demonstrating the effectiveness of process improvement patterns with mining results
Creators: name: Lohrmann, Matthias
name: Reichert, Manfred
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Business process design
subject: Business process governance
subject: Business process optimization
subject: Process intelligence
subject: Process mining
subject: DDC 004 / Data processing & computer science
subject: Reengineering (Management)
subject: Prozessmanagement
subject: Prozessoptimierung

description: Improving the operational efficiency of processes is an important goal of business process management (BPM). There exist many proposals with regard to process improvement patterns (PIPs) as practices that aim at supporting this task. Nevertheless, there is still a gap with respect to validating PIPs in terms of their actual business value for a specific organization. Based on empirical research and experience from consulting projects, this paper proposes a method to tackle this challenge. Our approach towards a-priori validation of process improvement patterns considers real-world constraints such as the role of senior stakeholders and opportunities such as process mining techniques. In the sense of an experience report, our approach as well as results are illustrated on the basis of a real-world business process from human resources management, covering a transactional volume of about 29,000 process instances over the period of one year. Overall, our proposal enables practitioners and researchers to subject PIPs to a sound validation procedure before taking any process implementation decision.
The computer-oriented Kantorovich - finite difference method and its application on bridge engineering.
Creators: name: Zhao, Junqing.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Engineering, Civil.

description: The Kantorovich-finite difference method has been developed and applied for analysis and design of bridge structures in this thesis. Firstly, the bridge deck is mapped into an unit square in the $\xi$-$\eta$ plane. Secondly, the governing partial differential equation of the deck is reduced to the ordinary differential equation in the longitudinal direction of the bridge by the routine Kantorovich method. Finally, the finite difference method is employed to solve the above-derived ordinary differential equation to get the displacements and internal forces. The present method has been examined on right, skewed or general slab bridge decks and box-girder bridges. Mindlin plate theory and Kirchhoff plate theory are incorporated into the differential equation and, as a result, the designer has the option of either including or excluding the effect of shear deformation of the plate in the analysis. Possible shear locking is avoided by the reduced integration technique. Numerical examples show that the proposed new numerical model is versatile, efficient and reliable.
The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models
Creators: name: Noelting, Svenja
name: Rentsch, Jakob
name: Freitag, Helma
name: Detjen, Katharina
name: Briest, Franziska
name: Moebs, Markus
name: Weissmann, Victoria
name: Exner, Samantha [U.A.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017

description: Background/Aims The therapeutic options for metastatic neuroendocrine tumors (NETs) are limited. As PI3K signaling is often activated in NETs, we have assessed the effects of selective PI3Kp110α inhibition by the novel agent BYL719 on cell viability, colony formation, apoptosis, cell cycle, signaling pathways, differentiation and secretion in pancreatic (BON-1, QGP-1) and pulmonary (H727) NET cell lines. Methods Cell viability was investigated by WST-1 assay, colony formation by clonogenic assay, apoptosis by caspase3/7 assay, the cell cycle by FACS, cell signaling by Western blot analysis, expression of chromogranin A and somatostatin receptors 1/2/5 by RT-qPCR, and chromogranin A secretion by ELISA. Results BYL719 dose-dependently decreased cell viability and colony formation with the highest sensitivity in BON-1, followed by H727, and lowest sensitivity in QGP-1 cells. BYL719 induced apoptosis and G0/G1 cell cycle arrest associated with increased p27 expression. Western blots showed inhibition of PI3K downstream targets to a varying degree in the different cell lines, but IGF1R activation. The most sensitive BON-1 cells displayed a significant, and H727 cells a non- significant, GSK3 inhibition after BYL719 treatment, but these effects do not appear to be mediated through the IGF1R. In contrast, the most resistant QGP-1 cells showed no GSK3 inhibition, but a modest activation, which would partially counteract the other anti-proliferative effects. Accordingly, BYL719 enhanced neuroendocrine differentiation with the strongest effect in BON-1, followed by H727 cells indicated by induction of chromogranin A and somatostatin receptor 1/2 mRNA-synthesis, but not in QGP-1 cells. In BON-1 and QGP-1 cells, the BYL719/everolimus combination was synergistic through simultaneous AKT/mTORC1 inhibition, and significantly increased somatostatin receptor 2 transcription compared to each drug separately. Conclusion Our results suggest that the agent BYL719 could be a novel therapeutic approach to the treatment of NETs that may sensitize NET cells to somatostatin analogs, and that if there is resistance to its action this may be overcome by combination with everolimus.
The obligation to observe the constitutions and decrees of Church authorities: An analysis of Canon 754.
Creators: name: Medina Balam, Mario.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Law.

description: To what extent does c. 754 give power to the ecclesiastical magisterium to require juridically from Christ's faithful the reception of its pronouncements? What is the meaning and purpose of the canon? The Author examines canon 754 in its historical, ecclesiological and juridical context. He divides his study into five chapters: the first offers a brief overview of the underlying ecclesiologies relating to the teaching office of the Church; the second deals with the sources of c. 754. The next two chapters approach the canon directly: its process of formulation and its interpretation (ch. 3), and a doctrinal and juridical analysis of it (ch. 4). The last chapter attempts to apply the canon to the life of the Church today. Two visions on the role of the ecclesiastical magisterium were present during the process of formulation of c. 754: one is represented by the principal sources of the canon, the epilogue of the Dogmatic constitution Dei filius of Vatican I and c. 1324 of the 1917 Code of Canon Law; both reflected, in some way, a juridical approach to the exercising of the office of the magisterium, whose particular office of teaching was marked by an apologetic attitude. The other was the vision of Vatican II, which rediscovered the role of the magisterium as a service. Thus, while c. 754 is more positive than its counterpart c. 1324 of the 1917 Code, it retains a voluntaristic juridical approach to the magisterial authority of pastors. Its present form seems to endow the ecclesiastical magisterium with the power to require juridically from the faithful an internal assent to its teachings. Therefore, the Author suggests that the appropriateness of maintaining the canon in the Code should be reconsidered in the future, or at least be transformed in the line that the Code of Canons of the Eastern Churches did. He also offers some guiding points to help Christ's faithful discern the nature of ecclesiastical documents to have an adequate response to them; he gives an overview of each legitimate authority referred to in c. 754. He thinks that not all doctrinal pronouncements fall under c. 754, instead, he divides into two categories the specific documents which the proper ecclesiastical authority enacts to propose doctrine and to proscribe erroneous opinions. Finally, he suggests that c. 754 must be interpreted in the light of some of the fundamental rights and duties of all the Christ's faithful regarding their participation in the teaching office of the Church, such as the right, and at times the duty to express their opinion publicly in the Church (c. 212 S 3), or their just freedom to research and express their findings in the field of sacred disciplines (c. 218). This might reduce the juridical significance of c. 754 on the magisterial authority of ecclesiastical pronouncements.
Mechanical Properties of Novel Auxetic Structures
Creators: name: Alomarah, Amer
Publisher: name: Swinburne
Year: 2024

description: Auxetic structures are an innovative class of cellular structures that have negative Poisson’s ratios (NPRs) and can be engineered in creative ways. The work that has been conducted in this thesis involved developing novel 2D and 3D auxetic cellular structures and investigating their mechanical performances. The developed auxetic structures showed promising mechanical properties compared with those popular structures.
The outcomes of this thesis could contribute towards using the developed structures in a wide range of potential applications. Therefore, this work paves the way to use the developed auxetic structures in the future as potential alternatives as cores for sandwich panels, medical stents, smart filters, sound absorbers, vibration-dampers, and human protection equipment.
Zwischen Erhalten und Erneuern - Entwicklung der "Alten Stadt" am Beispiel Freiburg im Breisgau
Creators: name: Bert, Paul
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 300 / Social sciences
subject: Cities and towns; Planning
subject: Freiburg im Breisgau
subject: Online-Publikation
subject: Ringvorlesung
subject: Stadtbild

description: Die Stadtentwicklung Freiburgs in der Nachkriegszeit war geprägt durch die Auseinandersetzung zwischen den "Modernisten und Konservativen", sowohl bei Stadtplanern als auch auf politischer Ebene. Im Gegensatz zu anderen Städten wächst die Bevölkerung Freiburgs nach wie vor. Bauen im Bestand, Stadtökologie und Nachhaltigkeit sind hier die Themen.
Zločin iz mržnje prema pripadnicima romske nacionalne manjine – Priručnik za žrtve
Creators: name: Musić, Siniša-Senad
name: Dabić, Tea
Publisher: name: Kuća ljudskih prava Zagreb
Year: 2021
Subjects: zločin iz mržnje
Romi

description: Priručnik daje odgovor na pitanja što je zločin iz mržnje, kome i kako ga prijaviti, koja prava pripadaju žrtvama zločina iz mržnje te koje vrste zaštite stoje na raspolaganju žrtvama zločina iz mržnje u odnosu na njihov specifičan položaj.

Priručnik stavlja naglasak na specifičan položaj pripadnika romske nacionalne manjine, a namijenjen je osobama koje su same bile metom zločina iz mržnje ili su svjedočile zločinu iz mržnje, kao i stručnim djelatnicima, organizacijama civilnog društva i svim drugim dionicima koji rade ili se u okviru svog djelovanja susreću sa žrtvama zločina iz mržnje.
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 265 (33. Jg.), November 2003
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Uni Ulm intern
subject: Universities; Germany; Ulm
subject: Ulm / Universität

description: N/A
Feasibility and Effectiveness of a Wearable Technology-Based Physical Activity Intervention in Preschoolers: A Pilot Study
Creators: name: Byun, Wonwoo
name: Lau, Erica
name: Brusseau, Timothy A.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The purpose of this pilot study was to evaluate the feasibility and the effectiveness of an intervention that employed a technology-based physical activity (PA) monitoring system and teacher-regulated strategies to promote PA in preschoolers. A total of 93 preschoolers (53% girls, 4.7 years) from 5 child care centers were recruited for a one-week intervention and randomly assigned into control (2 centers, n = 45) or intervention (3 centers, n = 48) group. Key intervention components included: (1) wearable device-based, real-time monitoring of children’s PA by classroom teachers and (2) teacher-regulated strategies for providing more opportunities for PA. Sedentary behavior (SED) and PA were measured using accelerometers. Overall, children in the intervention group showed significantly lower level of SED (31.6 vs. 33.6 min/h) and higher level of total PA (28.4 vs. 26.4 min/h) than children in the control group, after adjusting for age, sex, race, parent education level, parent perception of their child’s PA, BMI, and childcare centers. Teachers in the intervention group reported that the intervention was highly feasible to be implemented in their current classroom settings. In conclusion, we observed high acceptability and initial effectiveness of the current intervention. Subsequent research at larger-scale is warranted to fully evaluate the effectiveness of the intervention strategies tested in this study.
Les fondements normatifs de la théorie de l'agir communicationnel : le désaccord entre Jurgen Habermas et Karl-Otto Apel.
Creators: name: Simard, Sébastien.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Philosophy.

description: L'opposition entre Jurgen Habermas et Karl-Otto Apel quant aux fondements normatifs de la Theorie de l'Agir communicationnel suggere une divergence importante en ce qui concerne le rapport entre le Theoricien critique et la vie quotidienne. De sorte a situer cet enjeu theorique, nous prenons pour point de depart la question apelienne: la moralite factuelle du monde vecu peut-elle assurer un fondement normatif suffisant pour la Theorie de l'agir communicationnel? Cette question nous permet a la fois de delimiter les difficultes theoriques du projet habermassien, ainsi que la coherence interne du cheminement apelien. Nous poursuivons en renversant la question apelienne ainsi: l'argumentation transcendantale permet-elle une prise en consideration de l'intersubjectivite factuelle du monde vecu? L'approche apelienne, en quete de certitude morale, ecrase sous le poids de l'argumentation transcendantale la liberte des discussions pratiques. L'approche habermassienne, malgre certaines difficultes theoriques, delimite une sphere autonome des discussions pratiques ou le philosophe ne peut anticiper aucune presupposition morale ou transcendantale.
Investigating of LSPR spectra on a hybrid Fe3O4-Au within core-shell structure
Creators: name: Sujak, M
name: Putra, M H
name: Djuhana, D
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: DDC 540 / Chemistry & allied sciences
subject: Magnetochemistry
subject: Photocatalysis
subject: Fotokatalyse
subject: Magnetochemie

description: Abstract In this study, we have investigated the tunability of localized surface plasmon resonance (LSPR) spectra of the magneto-plasmonic system composed of Au-coated Fe3O4 (Fe3O4@Au) by public optical simulation, MNPBEM based on boundary element method calculation. The magneto-plasmonic system is modeled nanorod core-shell structure with three different core’s aspect ratio: 2.3, 4.3, and 6.3. The nanoparticle was immersed in water (1.33+0i). Then, we applied the electromagnetic field in parallel and perpendicular to the long axis of nanorod. Interestingly, the peak of LSPR spectra Fe3O4@Au shows blue-shifted at gold thickness toward around ∼50 nm and as the gold-shell keep growing, a red-shifted can be occurred on greater than ∼50 nm of thick gold-shell. The peak of LSPR spectra shows to shift to lower wavelength or blue-shift and produce narrow width spectra. Based on the result, we believe our observation can be utilized for tuning LSPR spectra from visible range to near-infrared such as photocatalysis application and biosensing with well-controlled of thicknesses.
title: Hemorragia Gastrointestinal
Creators: name: Lacoma Latre, Eva María
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Interventional vascular
subject: Gastrointestinal tract
subject: CT-Angiography
subject: Catheter arteriography
subject: Diagnostic procedure
subject: Haemorrhage

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
INTRODUCCIÓN: La Hemorragia Gastrointestinal es un problema clínico importante.
Con una mortalidad de un 14%. Involucra a diversos especialistas médicos; gastroenterólogos,
cirujanos y radiólogos intervencionistas. El papel del radiólogo es: -...