cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Involving patients’ perspective in the development of an internet- and mobile-based CBT intervention for adolescents with chronic medical conditions: findings from a qualitative study
Creators: name: Geirhos, Agnes
name: Lunkenheimer, Frederike
name: Holl, Reinhard W.
name: Minden, Kirsten
name: Schmitt, Andreas
name: Temming, Svenja
name: Baumeister, Harald
name: Domhardt, Matthias
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Chronic medical condition
subject: Internet-based cognitive behavioral therapy
subject: User-centered approach
subject: DDC 150 / Psychology
subject: Telemedicine
subject: Cognitive behavioral therapy
subject: Internet
subject: Adolescent
subject: Mental health
subject: Mental disorders; Therapy
subject: Qualitative research
subject: Telemedizin
subject: Kognitive Verhaltenstherapie
subject: Psychotherapie
subject: Computerunterstützte Kommunikation

description: Objective: A user-centered approach is critical for increasing the adherence to and effectiveness of an internetand mobile-based intervention program. Therefore, potential future intervention users were involved in the development of an internet- and mobile-based cognitive behavioral therapy program (iCBT) for adolescents and young adults (AYA) with chronic medical conditions and comorbid symptoms of anxiety or depression. We aimed to identify challenges and coping strategies of the intended target group, as well as their needs and preferred intervention characteristics for an iCBT program. Methods: Twenty AYA (aged 14–20, 60% females) with either type 1 diabetes (55%), juvenile idiopathic arthritis (25%) or cystic fibrosis (20%) were interviewed in condition-specific focus groups (4–11 participants per group) either via videoconferencing or face-to-face. Transcript verbatim data was analyzed using content analysis. Results: Frequently reported disease-specific burdens were among others fear of disease progression, nonacceptance of disease and stressful incidents related to and aversions against medical therapy. Most frequently reported coping strategies included, seeking social support and accepting the disease. Recommendations for the content of an iCBT for comorbid symptoms of anxiety and depression comprised: dealing with disease-related fears and getting advice on health-promoting lifestyles. iCBT characteristics considered preferable by participants were: providing individual feedback by a real-person; implementation of a feature to monitor treatment progress; youthful and varied content presentation; time per session not exceeding 1 h; non-involvement of parents. A mobile-based reminder feature was considered useful, and individual tailoring and self-determination of iCBT content was considered desirable. Conclusions: The findings highlight important patient perspectives and age-specific recommendations which can help design more optimal iCBT interventions for AYA with chronic medical conditions.
The projective hinge: phylogeny and ontogeny for a new descriptive geometry
Il cardine proiettivo: filogenesi e ontogenesi per una nuova geometria descrittiva
Creators: name: De Rosa, Agostino
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
descriptive geometry; theory and history of representational methods; stereotomy; contemporary art
geometria descrittiva; teoria e storia dei metodi e delle forme di rappresentazione; stereotomia; arte contemporanea

description: The architect- draughtsman uses a theoretical–graphic code whose foundations - of obvious Platonic lineage - attempt to organize and make sense to the reality. Perhaps the most powerful tool that he has in his hands  to translate the existing world in a dense and polysemous model and to envisage the future one, in a compelling and creative way, becomes from descriptive geometry. Today, the context in which the architect works is violently changed and the "geometry", in the digital image, seems to have lost memory of its projective origins. Two loci - one related to the stonecutting’s tradition, the other to the experiences of contemporary art - seem to be able to bring out in a renewed way, "the figures of the demonstration" associated with descriptive geometry.
description: Come è noto, l’architetto rappresentatore utilizza un codice teorico-grafico le cui fondamenta, di evidente discendenza platonica, tentano di organizzare il e dare un senso al reale. Forse lo strumento più potente che gli è toccato in sorte per tradurre il mondo esistente in un modello denso e polisemico e per prefigurare quello a venire, in modo convincente e creativo, è proprio quello fornitogli dalla geometria descrittiva. Oggi il contesto in cui il disegnatore opera è violentemente cambiato e la "geometria", nell’immagine digitale, sembra aver perso memoria della sua origine proiettiva. Due loci – uno legato alla tradizione del taglio delle pietre, l’altro alle esperienze dell’arte contemporanea - sembrano poter far riemergere, in modo inedito, "le figure delle dimostrazione" associate alla geometria descrittiva.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 13 - 22
Additional file 2 of Antithrombin use and mortality in patients with stage IV solid tumor-associated disseminated intravascular coagulation: a nationwide observational study in Japan
Creators: name: Taniguchi, Kohei
name: Ohbe, Hiroyuki
name: Yamakawa, Kazuma
name: Matsui, Hiroki
name: Kiyohide Fushimi
name: Yasunaga, Hideo
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 2: Table S1. ICD-10 codes and Japanese procedure codes for organ failure scores.
Memetics of representation
Memetica della rappresentazione
Creators: name: De Rubertis, Roberto
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
representation; geometry; evolution; memetics
rappresentazione; geometria; evoluzione; memetica

description: This article will discuss about the physiological genesis of representation and then it will illustrate the developments, especially in evolutionary perspective, and it will show how these are mainly a result of accidental circumstances, rather than of deliberate intention of improvement. In particular, it will be argue that the representation has behaved like a meme that has arrived to its own progressive evolution coming into symbiosis with the different cultures in which it has spread, and using in this activity human work “unconsciously”. Finally it will be shown how in this action the geometry is an element key, linked to representation both to construct images using graphics operations and to erect buildings using concrete operations.
description: In questo articolo analizzerò la genesi fisiologica della rappresentazione per poi illustrarne gli sviluppi, soprattutto in un’ottica evoluzionistica, e mostrerò come questi siano prevalente esito di circostanze accidentali, piuttosto che di deliberate volontà di perfezionamento.In particolare sosterrò che la rappresentazione si è comportata come un meme e che è pervenuta alla propria progressiva evoluzione entrando in simbiosi con le diverse culture in cui si è diffusa e servendosi, “inconsapevolmente”, in tale attività, dell’opera umana.Mostrerò quindi come in questa operazione la geometria sia un elemento chiave, legata alla rappresentazione sia nel costruire immagini tramite operazioni grafiche sia nel costruire edifici tramite operazioni concrete.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 23 - 26
Traditional and digital representation as languages to analyse and design architecture
Rappresentazione tradizionale e digitale come linguaggi per l’analisi ed il progetto d’architettura
Creators: name: De Sanctis, Aldo
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
architectural representation as language; architectural survey
rappresentazione come linguaggio; rilievo dell’architettura

description: If we think to the relationship, or rather to the state of necessity, which unites the architectonic figuration with the survey and the project, we can easily explain the interests that have characterized the evolution of methods and geometric rules for representing: the architectonic forms and the frameworks that we know come up as a consequence of the operative necessities of representation and geometric rules, in the sense that those forms and frameworks properly belong to the universe of their possibilities. The computer language can have the same role that the traditional representation has had in the past, namely it can help the generation of architectonic forms, becoming an active factor both for the creation of new dispositions for the projects both for the definition of new research methodologies, or of methodologies, canonical for the digital representation.
description: Se pensiamo allo stato di necessità che unisce la figurazione architettonica col rilievo ed il progetto, facilmente riusciamo a spiegare gli interessi, che nel tempo hanno caratterizzato l’evoluzione dei metodi per rappresentare: le forme architettoniche ed i loro assetti nascono per l’operatività della rappresentazione, ne sono una conseguenza diretta, nel senso che quelle forme e quegli assetti appartengono precisamente all’universo delle sue possibilità.Il linguaggio informatico può svolgere lo stesso ruolo che la rappresentazione ha avuto in passato, può, cioè, favorire lo studio di nuove forme e diventare fattore attivo sia per l’analisi e l’ideazione delle disposizioni architettoniche, che per la messa a punto di inedite modalità espositive, o di modalità, per così dire, canoniche della rappresentazione digitale.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 27 - 36
Additional file 1 of Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies
Creators: name: Vuyolwethu Mxinwa
name: Phiwayinkosi V. Dludla
name: Nyambuya, Tawanda M.
name: Kabelo Mokgalaboni
name: Sithandiwe E. Mazibuko-Mbeje
name: Nkambule, Bongani B.
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table 1S. PUBMED search strategy. Search Strategy run on 13 November 2019. Table 2S. Sensitivity analysis of studies included in meta-analysis reporting on the levels NK cell in T2D adult patients compared to healthy controls. Table 3S. Risk of bias assessment.
Prioritizing Areas for Habitat Conservation in the Face of Climate and Land-Use Change
Creators: name: Robillard, Cassandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: conservation
climate change
agriculture
Marxan
habitat loss
cost optimization

description: The selection of sites for biodiversity conservation is best done if it anticipates future challenges and efficiently accomplishes targets, given limited funding for such efforts. The first chapter of this thesis discusses how conservation practitioners might manage and enhance long-term survival for species whose ranges must shift as climate changes, across regions that present significant mobility barriers. I describe recommendations highlighting connectivity, refugia from climate change, adaptation, and restoration within agricultural landscapes in North America, but these recommendations are transferable elsewhere. The second chapter examines patterns of change in agricultural intensity and land price within Canada’s species-rich farmland between 1986 and 2011, and creates sequential cost-efficient plans to conserve resident species-at-risk within that time period, to determine how environmental and cost changes erode the efficiency of conservation plans. While sites initially selected as cost-efficient remained so through time, total plan costs increased, decreasing each plan’s ability to represent all species for a given budget. This emphasizes the urgent need for conservation within Canada’s farmland.
Systematization of the order of the methods of graphic representation. The perspective as matrix of methods
Sistematizzazione dell’ordine dei metodi di rappresentazione grafica. La prospettiva come matrice dei metodi
Creators: name: Fasolo, Marco; Università La Sapienza Di Roma
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
descriptive geometry; perspective; representation
geometria descrittiva; prospettiva; rappresentazione

description: As regards the order of the methods of exhibition graphic representation is intended to propose a sequence reverse to that of traditional exposures but at the same time in harmony with both the chronological order, historical, in which the methods themselves are shaped both with what can be considered the order of their expressive potential, their capacity is representative of three dimensional space in relation to the visuality of their content from the common matrix derivategli perspective. The order most commonly followed is: double orthographic projection, isometric, quoted projections, perspective and are expected instead to place the methods in what is thought to be intrinsically natural order, which is both historical and functional perspective, axonometric, method of projections, contour map.
description: In merito all’ordine espositivo dei metodi di rappresentazione grafici si intende proporre una sequenza inversa a quella delle esposizioni tradizionali ma contemporaneamente in armonia sia con l’ordine cronologico, storico, nel quale i metodi stessi si sono conformati sia con quello che può essere considerato l’ordine del loro potenziale espressivo, della loro capacità rappresentativa dello spazio tridimensionale in rapporto alla visività del loro contenuto derivategli dalla comune matrice prospettica. L’ordine più comunemente seguito risulta essere: doppia proiezione ortogonale, assonometria, proiezioni quotate, prospettiva; si ritiene invece di collocare i metodi in quello che si pensa essere l’ordine intrensicamente naturale, che è insieme storico e funzionale: prospettiva, assonometria, doppie proiezioni ortogonali, proiezioni quotate.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 37 - 40
A new stellar chemo-kinematic relation reveals the merger history of the milky way disk
Creators: name: Minchev, I.
name: Chiappini, C.
name: Martig, M.
name: Steinmetz, M.
name: De Jong, R. S.
name: Boeche, C.
name: Scannapieco, C.
name: Zwitter, T.
name: Wyse, R. F. G.
name: Binney, J. J.
name: Bland-Hawthorn, J.
name: Bienayme, O.
name: Famaey, B.
name: Freeman, K. C.
name: Gibson, B. K.
name: Grebel, E. K.
name: Gilmore, G.
name: Helmi, A.
name: Kordopatis, G.
name: Lee, Y. S.
name: Munari, U.
name: Navarro, J. F.
name: Parker, Q. A.
name: Quillen, A. C.
name: Reid, W. A.
name: Siebert, A.
name: Siviero, A.
name: Seabroke, G.
name: Watson, F.
name: Williams, M.
Publisher: name: Swinburne
Year: 2024

description: The velocity dispersions of stars near the Sun are known to increase with stellar age, but age can be difficult to determine, so a proxy like the abundance of alpha elements (e.g., Mg) with respect to iron, [α/Fe], is used. Here we report an unexpected behavior found in the velocity dispersion of a sample of giant stars from the Radial Velocity Experiment survey with high-quality chemical and kinematic information, in that it decreases strongly for stars with [Mg/Fe] > 0.4 dex (i.e., those that formed in the first gigayear of the Galaxy's life). These findings can be explained by perturbations from massive mergers in the early universe, which have affected the outer parts of the disk more strongly, and the subsequent radial migration of stars with cooler kinematics from the inner disk. Similar reversed trends in velocity dispersion are also found for different metallicity subpopulations. Our results suggest that the Milky Way disk merger history can be recovered by relating the observed chemo-kinematic relations to the properties of past merger events.
Geometry, crystal of thought
Geometria, ovvero il cristallo del pensiero
Creators: name: Marotta, Anna; Politecnico Di Torino
name: De Bernardi, Mauro Luca
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
architecture; geometry; formal thought
architettura; geometria; pensiero formale

description: You do not speak as you think, but you think as you speak: this means that as the flow of thought follows our language syntax, so the formal thinking, whether purposeful or interpretational, follows the geometric layout. Geometry is an axiomatic system that, if modernly it is purely formal, in ordinary life remains material: a true Kantian "a priori". Geometry pervades the civilized people’s life; we can take into consideration two aspects: firstly, the Geometry justify formal choices through fixed relationships between entities; secondly, Geometry makes understandable and communicable ideas. Our contribution aims to demonstrate how Geometry, from tradition to modernity, is still useful in its various forms.
description: Non si parla come si pensa, ma si pensa come si parla: ciò induce a dire che come il flusso del pensiero segue la sintassi della lingua madre, così il pensiero formale, sia esso interpretativo o propositivo, segue l’impianto geometrico. La Geometria è di fatto un sistema assiomatico che, se modernamente lo si è compreso come puramente formale, nella realtà dei comuni mortali nasce e rimane materiale: un vero “a priori” kantiano. Ora, le ragioni del “volere geometrico” che pervade la vita delle civiltà può avere svariate ragioni che scomodano svariate discipline: a noi può bastare la duplice considerazione che vede la Geometria tanto come mezzo per giustificare scelte formali attraverso sicure relazioni tra entità, quanto il filo logico che rende comprensibile e comunicabile una idea anche di pura fantasia. Il nostro contributo intende dimostrare, quanto sia utile ancora e sempre, dalla tradizione alla contemporaneità, la conoscenza della Geometria nelle sue varie forme.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 41 - 46
Les dictionnaires dans les systèmes de traduction automatique.
Creators: name: Guilbault, Isabelle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Language, Linguistics.

description: Machine translation (MT) is a relatively new field combining linguistics and computer science. From a linguistic perspective, one of the most important components of MT systems is undoubtedly dictionaries. Until now, few studies have been carried out on the role played by dictionaries in such systems. The objective of this thesis is therefore to advance research in machine lexicography, or more precisely, in bilingual machine lexicography. This thesis examines MT dictionaries in a certain number of systems in order to gain a better understanding of the role played by MT bilingual dictionaries in relation to other parts of the system. This is important since, unlike human translators who can choose to consult bilingual dictionaries whenever they wish, according to their own particular needs, MT systems dictate when consultation takes place and the type of information sought. Furthermore, the type of MT system (direct, transfer or interlingual) has a direct impact on the content and use of bilingual dictionaries. Bilingual dictionaries in direct systems, which do not contain unilingual dictionaries, usually contain more information than those in transfer or interlingual systems. However, the linguistic analysis of bilingual dictionaries in direct systems is less sophisticated than that of unilingual dictionaries in transfer or interlingual systems. This thesis also compares traditional bilingual dictionaries with MT bilingual dictionaries in order to determine to what extent it is possible to adapt a traditional bilingual dictionary entry for use in MT systems.
Describing to compute
Descrivere per calcolare
Creators: name: Rossi, Adriana; Seconda Università Di Napoli
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
governing modification digital representation; 3D modelling; generative design; evolutive model
rappresentazione digitale e governo della modificazione; modellazione 3D; progettazione generativa; modello evolutivo

description: In this paper the advantages due to the possibility of generating complex surfaces starting from bi-dimensional geometries by means of CAD softwares are discussed. Two case studies are presented to show the hypothetical variation of three primary choice cycles. The study of basic geometries (a), paths where the geometries are swept along (b), places occupied by the sections lofting the paths (c). The strong innovation contained in the continuity of invention process is deeply appreciated. This is especially true when that process is not the result of habit and finds its roots in the principles and in the criteria of geometry. Nothing is left to improvisation in this discipline: every concept is based on mathematical calculus.
description: Si discute dei vantaggi derivanti dalla possibilità di modellare geometrie di base per generare superfici complesse con l’ausilio dei programmi di aiuto alla progettazione assistita. Due casi-studio sono il pretesto per accennare all’ipotetica variazione parametrica di tre cicli di scelte primarie: 1) lo studio delle geometrie di base; 2) lo studio delle traiettorie assegnate ai percorsi lungo i quali queste vengono trascinate; 3) lo studio delle posizioni occupate dai profili cuciti lungo i percorsi. Consegue un tacito elogio per quanto profondamente innovativo si nasconde nella continuità del processo d’invenzione quando questo è sottratto alla assuefazione e trova le sue radici nei principi e nei criteri geometrici: una disciplina che nulla lascia all’improvvisazione, insistendo sulla concettualizzazione delle figure e del calcolo matematico.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 47 - 54
The Dogana courtyard in Palazzo Vecchio, the detail that enlightens the rule
Il cortile della Dogana in Palazzo Vecchio,  il dettaglio che illumina la regola
Creators: name: Bartoli, Maria Teresa; Università Di Firenze
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
mathematics and gothic architecture, new knowledge from surveying and digital drawing
matematica e architettura gotica, conoscenza rinnovata dal rilievo e dal disegno vettoriale

description: The apparent irregularity in the trapezium of the Dogana courtyard in Palazzo Vecchio hides an uncommon precise geometrical rule. Such a rule requires the knowledge of the triangle which the trapezium belongs to. The search of that triangle throws new light on the length measures of  the elder Arnolfo Palace. A design method based on geometrical theorems becomes evident, in which plan length measures are achieved through first and second degree equations. The plan offers directions to the three-dimensional palace development and to the surrounding urban design. The presence of the same triangle in the coeval Santa Maria Novella square gives evidence both for similarity in design of these two Florentine Republic plans and for relevance of new science knowledge in Gothic architecture.
description: L'apparente irregolarità  del Cortile della Dogana di Palazzo Vecchio nasconde una regola geometrico-matematica precisa e non banale. Questa regola richiede che sia noto il triangolo cui appartiene il trapezio. La ricerca del triangolo dà una nuova evidenza alle misure del primo nucleo del palazzo, l'edificio di Arnolfo. Si svela un metodo di progetto basato su teoremi geometrici, in cui la definizione delle lunghezze planimetriche è data dalla soluzione di equazioni di primo e secondo grado. La pianta offre poi indicazioni sia  altimetriche che di disegno urbano.  La presenza dello stesso triangolo nella coeva piazza di Santa Maria Novella è prova sia della contiguità di progettazione di questi eventi urbani sia della rilevanza del metodo geometrico messo in luce.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 55 - 64
Simvastatin and fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage
Creators: name: Riegger, Jana
name: Maurer, Svenja
name: Pulasani, Sai
name: Brenner, Rolf E.
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Statin therapy
subject: Anti-catabolic
subject: Antioxidative
subject: Cell protective
subject: DDC 610 / Medicine & health
subject: Osteoarthritis; Drug therapy
subject: Hydroxymethylglutaryl-CoA reductase inhibitors; Therapeutic use
subject: Cartilage
subject: Simvastatin
subject: Fluvastatin
subject: Osteoarthritis
subject: Pharmakotherapie
subject: Statine
subject: Simvastatin
subject: Fluvastatin

description: Joint injuries are known to induce pathomechanisms that might lead to posttraumatic osteoarthritis (PTOA). In this regard, statins with their pleiotropic effects could represent potential therapeutic agents in preventing the development of PTOA. Therefore, we investigated the effects of simvastatin and fluvastatin in a drop-tower-based human ex vivo cartilage trauma model. After 7 days, a mechanical impact (0.59 J) resulted in a decrease of the cell viability and increased expression of catabolic enzymes in cartilage explants. Simvastatin and fluvastatin treatment of impacted cartilage demonstrated cell protective effects in a concentration dependent manner. Moreover, statin therapy exhibited chondroprotective effects as demonstrated by attenuated expression of MMP-2 and MMP-13 as well as subsequent breakdown of collagen type II (after impact). Further analysis indicated antioxidative properties of the statins by upregulating the gene expression of SOD2 and suppression that of NOX2 and NOX4. Despite its protective effects, simvastatin impaired the biosynthesis of collagen type II, which was confirmed during chondrogenic redifferentiation of high passage chondrocytes. However, while long-term administration of statins for 4 weeks impaired chondrogenic redifferentiation, addition of simvastatin at low concentrations for 1 week exhibited a slightly promoting effect. In conclusion, our data imply that simvastatin and fluvastatin are suitable in terms of initial harm reduction after cartilage trauma.
Novel signal processing approaches for characterization of transient two-phase gas-liquid flow.
Creators: name: Kirpalani, Deepak.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Chemical.

description: The flow pattern generated in pipes for two-phase gas-liquid horizontal flows can significantly affect the efficiency of chemical process equipment. Since the early 1900's, scientists and engineers have investigated various methods for characterizing the flow patterns generated for various two-phase chemical systems. A notable effort was made by Baker to quantify physical fluid properties and correlate them to observed flow patterns in pipe flow. The primary objective of this research was to develop a flow pattern recognition system, for industrial implementation, that is suitable for characterizing transient two-phase flow patterns. Since the advent of computer and system control equipment, researchers have focused on quantifying flow characteristics by analyzing pressure fluctuation because the natural tendency of multiphase flow is to pulse as the fluid phases mix while moving along the pipe length. Recent developments in digital signal processing provide new methods for characterizing transient signals. A novel approach using wavelet transform analysis to study pressure fluctuations in two-phase flow systems has been developed in this research. Experimental development includes the design of a baseline system and a flow pattern recognition system. (Abstract shortened by UMI.)
Additional file 1 of Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies
Creators: name: Balaguer, Victor
name: Albayaty, Muna
name: Jimenez, Eulalia
name: Wählby-Hamrén, Ulrika
name: Astbury, Carol
name: Seoane, Beatriz
name: Malice, Marie-Pierre
name: Alejhandra Lei
name: Aggarwal, Ajay
name: Psallidas, Ioannis
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1 : e-Appendix 1. Methods. e-Appendix 2. Results. E-Table 1 Assessment of Dose Proportionality of Navafenterol in Studies A and B. E-Table 2 Assessment of Time-Dependency of Navafenterol in Studies A and B.
Family money: an exploration of contradictions and coherence in wealth management advice literature
Creators: name: Bowman, Dina
Publisher: name: Swinburne
Year: 2024

description: In her analysis of relationship advice books Hochschild (2003) suggests that self-help books illuminate ideological contradictions confronting groups within society, while offering strategies to reconcile these contradictions. Studies of advice books tend to focus on women and personal, domestic, health or relationship advice, perhaps because the contradictions facing women are more obvious than those facing men. In this exploratory paper I focus on a different form of self-help literature: wealth management advice. These books are addressed to those with power, unlike many other self-books. Wealth management advice books provide an insight into the competing imperatives of individual fulfilment, accumulation of wealth, loyalty to family, and broader social obligation. Wealth management texts articulate the contradictions that are often obscured by the familiar idea of provider masculinity. In this paper, I highlight the intertwined nature of economic and intimate activities and relations by identifying and analysing elements of wealth management advice.
Ribbed vaults of late Gothic in Sardinia
Volte nervate del tardogotico sardo
Creators: name: Casu, Paola; Università Di Cagliari
name: Pisu, Claudia; Università Di Cagliari
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
late Gothic architecture; ribbed vaults; geometry; dimensional analysis; 3D modeling
architettura tardogotica; volte; geometria; analisi dimensionale; modellazione 3D

description: The late Gothic construction practice, settled in the Spanish Mediterranean area, is based on predetermined geometric rules and is shown in religious buildings with ribbed vaults.The proportion between the sides of the area to cover, tracing plan of the ribs as a succession of corner bisectors, stereotomy problems and volumetric aspects, are just some of the elements that can describe the complex construction of a ribbed vault . The aim of this paper is to analyze the dimensional information of the late gothic ribbed vaults of Sardinia, in order to define the geometric and proportional rules for a correct drawing, establishing a standard procedure for the collection of measures and the construction of the 3D model of vaults.
description: La prassi costruttiva tardogotica, consolidata nell'area mediterranea d’influenza spagnola, si basa su regole geometriche prefissate e si manifesta in modo caratterizzante negli edifici religiosi con coperture a volta nervata.La proporzione tra i lati dell’area da coprire, il tracciamento in pianta delle nervature come successione di bisettrici d’angolo, i problemi di stereotomia, gli aspetti volumetrici sono solo alcuni degli elementi che possono descrivere il complesso costruttivo di una volta a crociera nervata. Obiettivo del presente lavoro è analizzare le informazioni dimensionali delle volte tardogotiche della Sardegna, al fine di determinare l’esistenza di regole geometriche e proporzionali ricorrenti per un corretto disegno, stabilendo una procedura standard per la raccolta delle misure e la costruzione del modello 3D delle volte.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 65 - 74
Investigation of factors influencing the implementation of two shared decision-making interventions in contraceptive care: a qualitative interview study among clinical and administrative staff
Creators: name: Munro, Sarah
name: Manski, Ruth
name: Donnelly, Kyla Z
name: Agusti, Daniela
name: Stevens, Gabrielle
name: Banach, Michelle
name: Boardman, Maureen B
name: Brady, Pearl
name: Bradt, Chrissy C
name: Foster, Tina
name: Johnson, Deborah J
name: Norsigian, Judy
name: Nothnagle, Melissa
name: Shepherd, Heather L
name: Stern, Lisa
name: Trevena, Lyndal
name: Elwyn, Glyn
name: Thompson, Rachel
Publisher: name: BioMed Central
Year: 2019

description: Background: There is limited evidence on how to implement shared decision-making (SDM) interventions in routine practice. We conducted a qualitative study, embedded within a 2 × 2 factorial cluster randomized controlled trial, to assess the acceptability and feasibility of two interventions for facilitating SDM about contraceptive methods in primary care and family planning clinics. The two SDM interventions comprised a patient-targeted intervention (video and prompt card) and a provider-targeted intervention (encounter decision aids and training). Methods: Participants were clinical and administrative staff aged 18 years or older who worked in one of the 12 clinics in the intervention arm, had email access, and consented to being audio-recorded. Semi-structured telephone interviews were conducted upon completion of the trial. Audio recordings were transcribed verbatim. Data collection and thematic analysis were informed by the 14 domains of the Theoretical Domains Framework, which are relevant to the successful implementation of provider behaviour change interventions. Results: Interviews (n = 29) indicated that the interventions were not systematically implemented in the majority of clinics. Participants felt the interventions were aligned with their role and they had confidence in their skills to use the decision aids. However, the novelty of the interventions, especially a need to modify workflows and change behavior to use them with patients, were implementation challenges. The interventions were not deeply embedded in clinic routines and their use was threatened by lack of understanding of their purpose and effect, and staff absence or turnover. Participants from clinics that had an enthusiastic study champion or team-based organizational culture found these social supports had a positive role in implementing the interventions. Conclusions: Variation in capabilities and motivation among clinical and administrative staff, coupled with inconsistent use of the interventions in routine workflow contributed to suboptimal implementation of the interventions. Future trials may benefit by using implementation strategies that embed SDM in the organizational culture of clinical settings.
Geometry and project: the example of  Piazza della Vittoria in Genoa
Geometria e progetto: l’esempio di Piazza della Vittoria a Genova
Creators: name: Cogorno, Luisa; Università Di Genova
name: Falcidieno, Maria Linda; Università Di Genova
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: ICAR17 - Disegno
geometry; project; composition
geometria; progetto; composizione

description: The study on the Genoese architectures in the thirties of Piazza della Vittoria  highlights the paramount  role of geometry for the project. The square, created by architect Marcello Piacentini between 1927 and 1930, stands opposite the railway station Genoa Brignole, pursuing a very logical representation: a new, very wide square surrounded by arcades ... the new civic-wordly heart of the  city (M. Piacentini). The methodological tool applied for the critical reading  was the  integrated relief: perceptual and historical analysis, relief and graphic representation of the whole and of the details, reconstruction of the compositional logic, study of materials used; the different phases showed the trasversality of the role of geometry –verified by the metric survey and by the compositive reading of the proportions- and the presence of dimensional canons unusual for the city.
description: Lo studio sulle architetture genovesi degli anni Trenta di piazza della Vittoria evidenzia il ruolo fondamentale della geometria a livello progettuale.La piazza, realizzata tra il 1927 e il 1930 su progetto dell’architetto Marcello Piacentini, si colloca di fronte alla stazione ferroviaria di Genova Brignole, perseguendo logiche di grande rappresentanza: una nuova vastissima piazza, contornata da porticati … nuovo cuore civico-mondano della città (M. Piacentini).Lo strumento metodologico di lettura critica applicato è stato il rilievo integrato: analisi percettive e storiche, rilievo e restituzione grafica dell’insieme e dei dettagli, ricostruzione della logica compositiva, studio dei materiali impiegati; le diverse fasi hanno evidenziato la trasversalità del ruolo della geometria -verificata dal rilevamento metrico e dalla lettura compositiva delle proporzioni- e la presenza di canoni dimensionali inusuali per la città.
description: DISEGNARECON; Vol. 5, n. 9 (2012) - Geometria - Costruzione - Architettura, a cura di Riccardo Migliari; 75 - 84
Cognitive processes underlying the syllabification of French print.
Creators: name: Desmarais, Chantal.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Psychology, Cognitive.

description: This program of research sought an answer to the following question: What is the nature of the mechanism underlying French readers' ability to identify syllabic boundaries in print? Two complementary approaches were taken to shed some light on this problem: first, we examined how the structural properties of syllables influence syllabification decisions; and second, we explored the relationship between syllabic structure and the issue of syllabic mediation in visual word recognition (VWR). In the first study, university students were asked to syllabify a list of 248 words (Experiment 1) or pseudowords (Experiment 2), in a paper-and-pencil syllabification task. The data were coded and then analyzed according to a framework representing the realm of all possible environments in which syllabic boundaries can be identified, within any given letter string. In the second study, participants were asked to verify the proper location for a syllabic boundary marker, which was inserted between the letters of isolated words displayed at the center of a computer screen (e.g., 'ca/bane' [shack]). In the syllable boundary verification (SBV) task, trisyllabic stimuli that contained a single medial consonant or medial consonant pair were contrasted either at the first or second syllabic boundary (i.e., Experiments 1 and 3: CV.C&barbelow;V.CV vs. CV C.CV.CV; Experiment 2: CV.CV.C&barbelow;V vs. CV.CV C.CV). The results showed that lexicality was not a factor in the untimed syllabification task (Study 1), where participants relied on simple heuristics to parse letter strings (i.e., spelling-to-sound translation, prescribed rule for separating geminate consonants). In the timed verification task (Study 2), a location-specific effect of syllabic structure was observed in the critical marker position for all three experiments, in addition to a word-frequency effect. Moreover, a reliable effect of marker serial position revealed an increase in response times towards the end of words. The pattern of results for this series of experiments is most consistent with the idea of a lexically-derived syllabic structure effect and inconsistent with one form of the syllabic mediation hypothesis (i.e., syllable-as-access-code hypothesis). Overall, the findings of both studies converge towards the following conclusion: The mechanism underlying the ability to identify syllabic boundaries in French print relies on multiple sources of constraint that vary according to task demands.
Additional file 1 of Plasma proteins facilitates placental transfer of polystyrene particles
Creators: name: Gruber, Michael M.
name: Hirschmugl, Birgit
name: Berger, Natascha
name: Holter, Magdalena
name: Radulović, Snježana
name: Leitinger, Gerd
name: Liesinger, Laura
name: Berghold, Andrea
name: Roblegg, Eva
name: Birner-Gruenberger, Ruth
name: Bjelic-Radisic, Vesna
name: Wadsack, Christian
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 1: Figure S1. Size distribution of 80 nm polystyrene particles. Figure S2. Electron microscopic images. Figure S3. Venn Diagramm. Figure S4. Volcano plot. Figure S5. Relative intensity of isolated fetal corona proteins. Figure S6. Albumin corona particle concentration in fetal circulation. Table S1. Statistics maternal arteries. Table S2. Statistics fetal arteries. Table S3. Statistics maternal veins. Table S4. Statistics fetal veins. References
Conductor and discriminant of Picard curves
Creators: name: Bouw, Irene I.
name: Koutsianas, Angelos
name: Sijsling, Jerön
name: Wewers, Stefan
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: 14H10 (primary)
subject: 11G30
subject: 14H25
subject: 14H50 (secondary)
subject: HYPERELLIPTIC CURVES
subject: ELLIPTIC-CURVES
subject: REDUCTION
subject: DDC 510 / Mathematics
subject: Integrals, Hyperelliptic
subject: Curves, Elliptic
subject: Invariants
subject: Invariante
subject: Reduktion

description: Abstract We describe normal forms and minimal models of Picard curves, discussing various arithmetic aspects of these. We determine all so‐called special Picard curves over Q with good reduction outside 2 and 3, and use this to determine the smallest possible conductor a special Picard curve may have. We also collect a database of Picard curves over Q of small conductor.
Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains
Creators: name: Wasan, Ellen K.
name: Zhao, Jinying
name: Poteet, Joshua
name: Mohammed, Munawar A.
name: Syeda, Jaweria
name: Orlowski, Tatiana
name: Soulsbury, Kevin
name: Cawthray, Jacqueline
name: Bunyamin, Amanda
name: Zhang, Chi
name: Fahlman, Brian M.
name: Krol, Ed S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Raynaud’s Phenomenon is a vascular affliction resulting in pain and blanching of the skin caused by excessive and prolonged constriction of arterioles, usually due to cold exposure. Nifedipine is a vasodilatory calcium channel antagonist, which is used orally as the first-line pharmacological treatment to reduce the incidence and severity of attacks when other interventions fail to alleviate the condition and there is danger of tissue injury. Oral administration of nifedipine, however, is associated with systemic adverse effects, and thus topical administration with nifedipine locally to the extremities would be advantageous. However, nifedipine is subject to rapid photodegradation, which is problematic for exposed skin such as the hands. The goal of this project was to analyze the photostability of a novel topical nifedipine cream to UVA light. The effect of incorporating the photoprotectants rutin, quercetin, and/or avobenzone (BMDBM) into the nifedipine cream on the stability of nifedipine to UVA light exposure and the appearance of degradation products of nifedipine was determined. Rutin and quercetin are flavonoids with antioxidant activity. Both have the potential to improve the photostability of nifedipine by a number of mechanisms that either quench the intermolecular electron transfer of the singlet excited dihydropyridine to the nitrobenzene group or by preventing photoexcitation of nifedipine. Rutin at either 0.1% or 0.5% (w/w) did not improve the stability of nifedipine 2% (w/w) in the cream after UVA exposure up to 3 h. Incorporation of quercetin at 0.5% (w/w) did improve nifedipine stability from 40% (no quercetin) to 77% (with quercetin) of original drug concentration after 3 h UVA exposure. A combination of BMDBM and quercetin was the most effective photoprotectant for maintaining nifedipine concentration following up to 8 h UVA exposure.
Naip (the murine homologue of NAIP) expression during mouse embryogenesis.
Creators: name: Ingram-Crooks, Jennifer.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Molecular.

description: The childhood spinal muscular atrophies (SMAs) are autosomal recessive neurodegenerative conditions characterized by degeneration of lower motor neurons classified based on the age of onset and clinical severity. Type I is the most common and severe form of SMA with clinical presentation either in utero or immediately after birth. The gene encoding NAIP (Neuronal Apoptosis Inhibitory Protein) has been proposed to be a modulator of the severity of SMA and is frequently deleted in type I SMA. In this study I have assessed Naip (murine homologue of NAIP) transcript levels during mouse embryogenesis. Naip mRNA is present in the developing brain and spinal cord of E9.5 to E14.5 mouse embryos as detected by various in situ hybridization techniques. It is also found in the embryonic liver, the branchial arches, the nasal epithelium and in the future digits. At E16.5 Naip transcripts were found in the marginal zone of the lateral ventricle, the follicles of the vibrissae, in the retina and in the intestinal villi. These results are the first report of Naip gene transcript levels in embryogenesis. One model of SMA pathogenesis involves motor neuron attrition in the second and possibly third trimester of gestation. Our observation of Naip transcripts in the spinal cord between E9.5 and E14.5 (equivalent to the second trimester) is consistent with a role for Naip in modifying SMA severity.
БИТИМНИНГ ҚОНУН ТАЛАБ ҚИЛАДИГАН ШАКЛИГА РИОЯ ЭТМАСЛИКНИНГ ОҚИБАТЛАРИ
Creators: name: Саттаров, О.И.
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада битимнинг қонун талаб қиладиган шаклига риоя этмасликнинг ҳуқуқий оқибатлари таҳлил қилинади. Мақолада битимнинг шакли фуқаролик ҳуқуқий муносабатларда муҳим аҳамиятга эгалиги, у битимнинг ҳақиқийлигини таъминлаш ва ҳуқуқий низоларнинг олдини олишда катта рол ўйнаши таъкидланади. Қонун талаб қиладиган шаклга риоя этилмаган битимлар ҳақиқий эмас деб топилиши учун қонунчиликда тўғридан-тўғри кўрсатилган ҳолатлар келтириб ўтилади. Шунингдек, суд амалиётида бундай битимларнинг ҳуқуқий ҳолати ва уларнинг низоли битим сифатида баҳоланиши ҳам кўриб чиқилади.