cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supporting awareness in instant messaging: an empirical study and mechanism design
Creators: name: Tran, Minh Hong
name: Yang, Yun
name: Raikundalia, Gitesh K.
Publisher: name: Swinburne
Year: 2024

description: Supporting awareness plays a prominent role in facilitating natural and effective communication in Instant Messaging (IM). This paper reports our empirical study of awareness in IM, using an online survey and face-to-face interviews to identify user needs for awareness support. The study has identified three themes, including awareness of multiple concurrent conversations, presence awareness of a group conversation, and visibility of moment-to-moment listeners and viewers. The study showed that these three types of awareness are necessary but have been either ineffectively supported or ignored by current IM systems. Drawing on these findings, we have designed three awareness features to support these three categories of awareness. Conversation Dock provides awareness of multiple conversations; Group List provides presence awareness in a group chat by showing who are no longer in the group chat and who are going to join the chat; and Track View provides awareness of in-progress listeners in voice conversations and in-progress viewers in video conversations.
Comparing Standardized and Parent-Reported Motor Outcomes of Extremely Preterm Infants
Creators: name: Morgan-Feir, Maeve
name: Abbott, Andrea
name: Synnes, Anne
name: Creighton, Dianne
name: Pillay, Thevanisha
name: Zwicker, Jill G.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Extremely preterm infants are at increased risk of motor impairment. The Canadian Neonatal Follow-Up Network (CNFUN) afforded an opportunity to study the outcomes of extremely preterm children. The purpose of this study was to compare 18-month corrected age (CA) motor outcomes of extremely preterm infants with parent-reported functional outcomes at 3 years CA. CNFUN data of 1376 infants were used to conduct chi-square analyses to compare Bayley-III motor scores (composite, gross, and fine motor) at 18 months CA with parent-reported Ages and Stages Questionnaire motor scores (gross and fine motor) at 3 years CA. The correlation of motor scores at 18-months CA with parent-reported gross and fine motor scores at 3 years CA was also examined. We found that 1 in 5 infants scoring within or above the average range on the Bayley-III had parent-reported functional fine and gross motor difficulties at 3 years CA. Bayley-III scores were only moderately correlated with functional motor outcomes. Results of the study suggest that the Bayley-III at 18 months CA was able to detect the majority of infants with motor problems, but not all; therefore, ongoing follow-up of extremely preterm infants is required. The Bayley-III motor composite score has greater clinical utility compared to sub-scale scores.
Die Münsterberg-Täuschung
Creators: name: Kreiner, Welf A.
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Café wall illusion
subject: Kanizsa-Dreieck
subject: Münsterberg
subject: Size constancy
subject: Subjective contour
subject: Virtuelle Linie
subject: Visual illusion
subject: DDC 530 / Physics
subject: Cross talk
subject: Irradiation
subject: Optical illusions
subject: Größenkonstanz
subject: Visuelle Wahrnehmungstäuschung
subject: Optische Täuschung
subject: Kanizsa-artige Figur

description: Der Stimulus wird in seinen Elementen variiert und auf diese Weise deren Einfluss systematisch untersucht. Die Beobachtungen werden mit unterschiedlichen Erklärungsansätzen verglichen. Der Täuschungseffekt wird hier auf eine sich periodisch wiederholende Untereinheit des Stimulus zurückgeführt, in der eine Linie zwei aufeinander folgende Quadrate links und rechts der Achse verbindet. Deren Symmetrieeigenschaften begünstigen die Wahrnehmung einer virtuellen Linie, die in einem spitzen Winkel zur Figurenachse verläuft. Es wird angenommen, dass diese in Wechselwirkung tritt mit der realen vertikalen Verbindungslinie und so deren wahrgenommene Richtung ändert. Eine wechselseitige Beeinflussung bei der Signalverarbeitung gleichzeitig wahrgenommener Elemente wird in Zusammenhang gebracht mit einem Phänomenen in der Nachrichtentechnik, dem Übersprechen oder cross talk/XT. Durch eine Veränderung der geometrischen Konstellation wird auch ein vergleichbarer Neigungseffekt an einer von Kitaoka veröffentlichten zweidimensionalen Variante untersucht, bei der quadratische Elemente einzelnen Abschnitten von horizontal und vertikal verlaufenden Linien dieselben Symmetriemerkmale verleihen wie in der der Münsterberg-Figur. Es wird eine neue Variante der Münsterberg-Täuschung präsentiert.
La nature de la philosophie : le débat entre Alexandre Kojève et Leo Strauss.
Creators: name: Provencher-Gravel, Alexandre.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Philosophy.

description: Cette thèse cherche à identifier le véritable point de litige du débat entre Alexandre Kojève et Leo Strauss, tel qu'on le retrouve dans l'ouvrage De la Tyrannie . Ce débat naît en premier lieu de leur désaccord sur l'implication politique du philosophe, mais il dépasse largement les termes de ce problème, ce qui rend ardu l'identification du coeur du débat. Nous soutenons que le point de litige fondamental n'est pas telle ou telle question philosophique particulière (comme la question de la relation entre la philosophie et la tyrannie), mais la hiérarchie des problèmes philosophiques. Pour Kojève, le lieu où doit se tenir le débat philosophique est celui du problème de la connaissance. Pour Strauss, c'est la question de la nature de l'âme et de sa fin qui doit faire l'objet premier du débat philosophique.
The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model
Creators: name: Begum, Nusrat J.
name: Glatting, Gerhard
name: Wester, Hans-Juergen
name: Eiber, Matthias
name: Beer, Ambros
name: Kletting, Peter
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Small Molescules
subject: Tumor
subject: Binding
subject: DDC 610 / Medicine & health
subject: Pharmacokinetics
subject: Prostatic neoplasms; Therapy
subject: Models, Biological
subject: Drug design
subject: Pharmakokinetik
subject: Nanomedizin
subject: Modellierung
subject: Prostatakrebs

description: The aim of this work was to investigate the effect of ligand amount, affinity and internalization of prostate-specific membrane antigen (PSMA)-specific ligands on the activity concentrations for PET/ CT imaging and on the absorbed doses for therapy. A physiologically-based pharmacokinetic (PBPK) model for PSMA-specific ligands was implemented. Thirteen virtual patients with metastatic castrationresistant prostate cancer were analysed. Simulations were performed for different combinations of association rates kon (0.1–0.01 L/nmol/min), dissociation rates koff (0.1–0.0001 min−1), internalization rates λint (0.01–0.0001 min−1) and ligand amounts (1–1000 nmol). For imaging the activity was normalized to volume and injected activity (68Ga-PSMA at 1 h). For therapy the absorbed dose was calculated for 7.3 ± 0.3 GBq 177Lu-PSMA. The effect of the investigated parameters on therapy were larger compared to imaging. For imaging, the combination of properties leading to the highest tumour uptake was kon = 0.1 L/nmol/min, koff = 0.01 min−1 for typical ligand amounts (1–10 nmol). For therapy, the higher the internalization rate, the larger was the required ligand amount for optimal tumour-tokidney ratios. The higher the affinity, the more important was the choice of the optimal ligand amount. PBPK modelling provides insight into the pharmacokinetics of PSMA-specific ligands. Further in silico and in vivo studies are required to verify the influence of the analysed parameters.
L'écriture poétique au féminin en Afrique noire francophone (1965-1993) : spécificités et originalités.
Creators: name: Ouédraogo-Bassolé, Angèle.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Literature, African.

description: Longtemps considerees comme les grandes absentes de la scene litteraire africaine, les ecrivaines africaines s'imposent de plus en plus et veulent faire entendre leurs voix. Apres une presence-absence de trois decennies, elles revendiquent la place qui leur revient et s'insurgent contre le silence qui regne autour de leur travail de creation dans un contexte socio-culturel fait de tabous, de traditions et de pratiques hostiles. Nous nous proposons dans cette these d'examiner les voies qu'empruntent des poetesses de trois pays africains francophones au sud du Sahara et de faire ressortir les grandes tendances de leurs ecritures rebelles. La sociocritique, au moyen de la notion du discours social, est une methode tout indiquee pour apprehender une telle ecriture dont le fondement principal est une lutte permanente: lutte identitaire, lutte de reconnaissance de leur creation, lutte de survie dans un monde d'hommes. Comment le social s'articule-t-il dans !es textes de ces poetesses? Quelle est la portee sociale de ces textes? Telle est la double question a laquelle nous essaierons de repondre a travers l'etude de quelques uns de leurs recueils. Nous degagerons les caracteristiques essentielles de I'ecriture poetique de ces femmes africaines qui ont du briser des tabous considerables pour acceder a l'ecriture. L'ecriture apparai t aux yeux de ces femmes comme une veritable arme de combat. Elle leur permet de reduire un peu plus chaque fois l'espace infernal et sournois du silence. Leur parole se fait demiurgique et l'echo de leurs voix, percutant. C'est a la decouverte de ces Promethees nouvelles venues d'afrique que nous vous convions a travers cette these.
The GLASS-JWST Early Release Science Program. II. Stage I Release of NIRCam Imaging and Catalogs in the Abell 2744 Region
Creators: name: Paris, Diego
name: Merlin, Emiliano
name: Fontana, Adriano
name: Bonchi, Andrea
name: Brammer, Gabriel
name: Correnti, Matteo
name: Treu, Tommaso
name: Boyett, Kristan
name: Calabrò, Antonello
name: Castellano, Marco
name: Chen, Wenlei
name: Yang, Lilan
name: Glazebrook, Karl
name: Kelly, Patrick
name: Koekemoer, Anton M.
name: Leethochawalit, Nicha
name: Mascia, Sara
name: Mason, Charlotte
name: Morishita, Takahiro
name: Nonino, Mario
name: Pentericci, Laura
name: Polenta, Gianluca
name: Roberts-Borsani, Guido
name: Santini, Paola
name: Trenti, Michele
name: Vanzella, Eros
name: Vulcani, Benedetta
name: Windhorst, Rogier A.
name: Nanayakkara, Themiya
name: Wang, Xin
Publisher: name: Swinburne
Year: 2024

description: We present images and a multiwavelength photometric catalog based on all of the JWST NIRCam observations obtained to date in the region of the Abell 2744 galaxy cluster. These data come from three different programs, namely, the GLASS-JWST Early Release Science Program, UNCOVER, and the Director’s Discretionary Time program 2756. The observed area in the NIRCam wide-band filters—covering the central and extended regions of the cluster, as well as new parallel fields—is 46.5 arcmin2 in total. All images in eight bands (F090W, F115W, F150W, F200W, F277W, F356W, F410M, and F444W) have been reduced adopting the latest calibration and reference files available. Data reduction has been performed using an augmented version of the official JWST pipeline, with improvements aimed at removing or mitigating defects in the raw images and improving the background subtraction and photometric accuracy. We obtain an F444W-detected multiband catalog, including all NIRCam and available Hubble Space Telescope data, adopting forced-aperture photometry on point-spread-function-matched images. The catalog is intended to enable early scientific investigations and is optimized for the study of faint galaxies; it contains 24,389 sources, with a 5σ limiting magnitude in the F444W band ranging from 28.5 AB to 30.5 AB, as a result of the varying exposure times of the surveys that observed the field. We publicly release the reduced NIRCam images, associated multiwavelength catalog, and the code adopted for 1/f noise removal with the aim of aiding users in familiarizing themselves with JWST NIRCam data and identifying suitable targets for follow-up observations.
A feminist family agenda: putting the mother back into sole parenting
Creators: name: Branigan, Elizabeth
name: Keebaugh, Shannon
Publisher: name: Swinburne
Year: 2024

description: In this article a feminist approach is taken towards affirming the position of single mothers within policy debates concerning sole parents. The article examines the ways in which the interests of single mothers may be subsumed within the generic terms 'sole parent'. It points out that although women generally bear most of the costs of providing for children after relationship breakdowns, recent policy initiatives have resulted in tax benefits to single fathers who undertake 10 percent of the care of their children. The article suggests that the inequality of income support is one effect of the efforts of a vocal male minority of single fathers to vilify single mothers and misrepresent their motives. It argues that gender neutral policies in relation to sole parents fail to recognise that post separation poverty is intrinsically gendered.
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 256 (32. Jg.), Oktober 2002
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Uni Ulm intern
subject: Universities; Germany; Ulm
subject: Ulm / Universität

description: N/A
The evolution of land plants inferred using domains D-F of the largest subunit of RNA polymerase II.
Creators: name: Malik, Shehre-Banoo.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Botany.

description: The aim of this project has been to develop the use of the nucleotide and amino acid sequences of the largest subunit of RNA polymerase II (RPB1) to study the evolutionary relationships of diverse land plants. 1.3 kb of this gene, which includes 900bp of coding sequence corresponding to regions D-F of the protein, have been cloned and sequenced from genomic DNA of seven plant species, one from each of seven divisions. 900 bp of cDNA sequence of regions D-F of RPB1 from Zea mays revealed identity with the genomic sequence. Phylogenetic analysis of these nucleotide and corresponding amino acid sequences by parsimony, neighbor-joining and maximum likelihood methods revealed inconsistent results. The maximum-likelihood method presented the best resolved trees. It is unlikely that the inconsistencies are the result of compositional biases, multiple substitutions, or unequal substitution rates. Analysis of amino acid sequences of regions D-F and F-H of RPB1 in animals, plants and fungi showed that animals are more closely related to plants than to fungi, contrary to recent literature. In comparing regions D-F of the largest subunits of RNA polymerases I, II and III (RPA1, RPB1 and RPC1) of all eukaryotes, though, the evolutionary relationships of the major eukaryotic kingdoms were not resolved but RPA1 was found to be more closely related to RPB1 than to RPC1. Since analyses in the literature of longer RPB1 sequences from fewer taxa did clearly resolve relationships of major eukaryotic lineages, this study shows that region D-F of this gene is too short to be informative. Due to the conserved nature of this partial sequence, it appears that a longer sequence from this gene with more synapomorphic sites is required to better assess the evolutionary relationships of plants.
Submission under the United Nations Framework Convention on Climate Change and the Kyoto Protocol 2020
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Klimarahmenkonvention
subject: Emissionsinventar
subject: Treibhausgasemission
subject: UNFCCC
subject: emissions inventory
subject: greenhouse gas emission
subject: Climate | Energy

description: As a Party to the United Nations Framework on Climate Change (UNFCCC), since 1994 Germany has been obliged to prepare, publish and regularly update national emission inventories of greenhouse gases. Pursuant to Decision 24/CP.19, all Parties listed in ANNEX I of the UNFCCC are required to prepare and submit annual National Inventory Reports (NIRs) containing detailed and complete information on the entire process of preparation of such greenhouse-gas inventories. The purpose of such reports is to ensure the transparency, consistency and comparability of inventories and support the independent review process. Quelle: http://www.umweltbundesamt.de
description: As a Party to the United Nations Framework on Climate Change (⁠UNFCCC⁠), since 1994 Germany has been obliged to prepare, publish and regularly update national emission inventories of greenhouse gases. Pursuant to Decision 24/CP.19, all Parties listed in ANNEX I of the UNFCCC are required to prepare and submit annual National Inventory Reports (NIRs) containing detailed and complete information on the entire process of preparation of such greenhouse-gas inventories. The purpose of such reports is to ensure the transparency, consistency and comparability of inventories and support the independent review process.
The role of different scinderin domains in the control of actin filament dynamics and regulated exocytosis.
Creators: name: Pene-Dumitrescu, Teodora.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Pharmacology.

description: In chromaffin cells, cortical F-actin disassembly in response to stimulation allows the movement of secretory vesicles towards exocytotic sites. Scinderin (Sc), a Ca2+-dependent F-actin severing protein, controls F-actin dynamics. The Sc gene has previously been cloned in our laboratory. Sc has six domains with three actin-binding sites in domains 1, 2 and 5, two PIP2 in domains 1 and 2 and two Ca2+-binding sites. In order to obtain additional data on the role of Sc domains in secretion, we performed experiments with a human growth hormone reporter gene (hGH) system for regulated exocytosis, and different GFP-fusion Sc constructs: Sc1--6, Sc1--2 (the first two domains of Sc), Sc5 (5th domain of Sc), ScL5 (5th domain lacking the third actin binding site of Sc), and ScABS3. Cortical F-actin distribution evaluated by rhodamine-phalloidine staining, in resting and stimulated cells (56 mM K+), showed that cells overexpressing Sc1--6 or Sc1--2 had an increased F-actin disassembly upon stimulation, whereas cells overexpressing Sc5 or ScABS3 had a decreased F-actin disassembly. No significant difference in F-actin assembly/disassembly was obtained for cells overexpressing ScL5. Increased hGH release in response to stimulus was found for cells overexpressing Sc1--6 or Sc1--2 when compared to cells transfected with vector alone. Cells overexpressing Sc5 or ScABS3 showed decreased hGH release in response to stimulus. These results suggest that during secretion the N-terminal half of the protein involved in F-actin severing and the C-terminal domains of Sc are responsible for actin polymerization. Thus, it appears that Sc functions as a molecular switch in the control of actin dynamics during secretion.
Supplementary document for Acousto-optic modulation of a wavelength-scale waveguide - 5045600.pdf
Creators: name: Sarabalis, Christopher
name: Van Laer, Raphaël
name: Patel, Rishi
name: Dahmani, Yanni
name: Jiang, Wentao
name: Mayor, Felix
name: Safavi-Naeini, Amir
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Appendices including a derivation of the dynamics and additional data characterizing the device.
A wider road: A case study of a chief education officer.
Creators: name: Fedrau-Ens, Carol.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Education, Administration.

description: Chief Education Officers must understand and work within and beyond the complexities of their school systems. They must balance public policy functions with the administration of system business with the advancement of educational programs. They have responsibilities for forging and communicating shared values, goals, and meanings. CEOs work in dynamic, interactive contexts. The purpose of this study was to explore, through the investigation of a CEO in action, political and cultural aspects of leadership, their interconnections, and the personal lens through which a CEO filtered these aspects. The study undertook the investigation of two critical incidents. One explored the development, among four school districts, of the shared delivery of special education services. A second examined the establishment of an alternate, church-affiliated school within a public education system. CEO leadership in these incidents revealed interrelated themes of practice. One was the development of shared vision, out of the CEO's personal vision in one case and out of a CEO group vision in the other. Also important was the CEO's knowledge of the contexts in which he worked, that is, groups, events, and relationships among groups and events, and his use of this contextual knowledge. In both incidents, the CEO used similar interpersonal processes to bring about satisfactory resolutions. Interwoven through these themes was the CEO's attention to political and cultural aspects of leadership. Findings suggested that CEO leadership occurred within interactive contexts of internal and external forces which, at any given point, operated in supportive or constraintive ways. The study concluded that the concept of a personal aspect of leadership underlies a CEO's choices and ways in which political and cultural aspects were processed. The study supported the importance of context as part of what enabled the CEO to exercise leadership in the way he did during the incidents of the study.
An exploratory study on the operation videoconferencing in bi-national tutorials
Creators: name: Meulenberg, Paul
name: Rees, Murray
Publisher: name: Swinburne
Year: 2024

description: Research in the area of using newer technologies such as videoconferencing via the Internet in tutorials is limited with even less covering the issue of effectiveness as a learning device. This technology enables expansion of the international marketing tutorial to include other countries/cultures. This study uses a case study methodology to investigate the conduct of binational tutorials to see if videoconferencing adds value to the learning experience of students. Two tutorials were conducted between students in two universities in Australia and Hong Kong. The students involved were positive with regards to interaction, engagement, motivation, interest in learning and felt comfortable with videoconferencing their tutorials. Issues involved with this project included: time differences (project length, semester timing, timetabling), role of champions, and common curricula. The authors derive human and pedagogical recommendations for running bi-national tutorials using videoconferencing.
Characterization of a haemolymph storage protein and its relationship to insect weight and development in the European corn borer, Ostrinia nubilalis Hubner (Lepidoptera:Pyralidae).
Creators: name: McKee, Susan Elaine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Entomology.

description: In this study I identified and characterized a storage protein in the European corn borer, Ostrinia nubilalis. The protein was identified as a storage protein by its native molecular weight of approximately 500 kDa and the observation that it increased in abundance throughout larval development and diminished with adult development. The protein had the characteristics of an arylphorin-like storage protein because it is a heterohexamer and is the most abundant protein in the haemolymph, increasing to the intermoult period with a decline just prior to pupation. Larval weight accounts for much of the variation in storage protein levels in the fat body (90%) and intact larvae (80%). Similar results were found with larval age and storage protein levels (80% for both fat body and intact larvae). Since nutrition has been proposed as a regulator of storage protein levels, I examined the relationship between storage protein levels, protein quality in the diet and larval weight. There was no significant effect of protein quality in the diet on storage protein levels after correcting for the weight of the larvae. Finally, I examined how development was affected by protein quality in the insect's diet. Corn borers fed poorer diets could compensate by consuming more and increasing their larval duration, however, they did so at lower pupal weights than those corn borers on the standard diet. Logistic regression analysis showed that pupal weight had a significant effect on survival, suggesting that heavier pupae are more likely to survive to the adult stage than lighter pupae. (Abstract shortened by UMI.)
Driving force and nonequilibrium vibronic dynamics in charge separation of strongly bound electron–hole pairs
Creators: name: Somoza, Alejandro D.
name: Lorenzoni, Nicola
name: Lim, James
name: Huelga, Susana F.
name: Plenio, Martin B.
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Computational methods
subject: Devices for energy harvesting
subject: Electron transfer
subject: Nanoscale biophysics
subject: DDC 530 / Physics
subject: Charge exchange
subject: Biophysics
subject: Elektronentransfer

description: Electron-hole pairs in organic photovoltaics efficiently dissociate although their Coulomb-binding energy exceeds thermal energy at room temperature. The vibronic coupling of electronic states to structured vibrational environments containing multiple underdamped modes is thought to assist charge separation. However, non-perturbative simulations of such large, spatially extended, electronic-vibrational (vibronic) systems remain an unmet challenge which current methods bypass by considering effective one-dimensional Coulomb potentials or unstructured environments where the effect of underdamped modes is ignored. Here we address this challenge with a non-perturbative simulation tool and investigate the charge separation dynamics in one, two and three-dimensional donor-acceptor networks to identify under what conditions underdamped vibrational motion induces efficient long-range charge separation. The resulting comprehensive picture of ultrafast charge separation differentiates electronic or vibronic couplings mechanisms for a wide range of driving forces and identifies the role of entropic effects in extended systems. This provides a toolbox for the design of efficient charge separation pathways in artificial nanostructures.
Generation of anti-human apolipoprotein E isoform-specific monoclonal antibodies.
Creators: name: Ejtehadian, Tahereh.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Molecular.

description: The objectives of the present study were: (i) to establish an immunization protocol for the preparation of monoclonal antibodies (mAbs) specific for epitopes that are polymorphic in humans, (ii) to use this protocol to prepare anti-apoE mAbs that are either apoE isoform-specific or are antibody mimetics of the lipoprotein (LDL) receptor. We immunized mice that carry a transgene encoding apoE of one isoform with a second isoform of human apoE. Two immunization protocols were used. In protocol 1, mice that carried an apoE3 transgene were immunized with either apoE4), a natural apoE variant apoE that is defective in binding to the LDL receptor, or both. We hoped to obtain anti-apoE4-specific mAbs. In protocol 2, apoE transgenic mice were immunized with apoE3 and apoE4. We anticipated that we would generate mAbs that recognize apoE3 but not apoE4 and mAbs that recognize the same conformational apoE epitope that is recognized by the LDL receptor. Mice showed a weak anti-apoE immune response that had the predicted isoform specificity. Only one of the nine fusions generated stable, apoE-specific hybridomas. Of the 7 anti-apoE mAbs obtained, none possessed the isoform-specificity predicted from protocol 1. Two of the mAbs, 9F3 and 7D4 reacted well with apoE3 and apoE4 but failed to react with apoE2. The epitopes for both mAbs were mapped to a region that coincides with the apoE LDL receptor-binding site. Other anti-apoE mAbs could effectively compete with 7D4 and 9F3 for binding to immobilized apoE. (Abstract shortened by UMI.)
Wie gut können wir vergangene und zukünftige Veränderungen des Wasserhaushalts quantifizieren?
Creators: name: Merz, Bruno
Publisher: name: Bundesanstalt für Gewässerkunde, Koblenz
Year: 2012
Subjects: subject: Water resources research

description: Hydrologie und Wasserbewirtschaftung / BfG – Jahrgang: 56.2012,5 - ISSN 1439-1783
Supplementary document for Acousto-optic modulation of a wavelength-scale waveguide - 5045600.pdf
Creators: name: Sarabalis, Christopher
name: Van Laer, Raphaël
name: Patel, Rishi
name: Dahmani, Yanni
name: Jiang, Wentao
name: Mayor, Felix
name: Safavi-Naeini, Amir
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Appendices including a derivation of the dynamics and additional data characterizing the device.
The host galaxy of FRB 20171020A revisited
Creators: name: Lee-Waddell, Karen
name: James, Clancy W.
name: Ryder, Stuart D.
name: Mahony, Elizabeth K.
name: Bahramian, Arash
name: Koribalski, Bärbel S.
name: Kumar, Pravir
name: Marnoch, Lachlan
name: North-Hickey, Freya O.
name: Sadler, Elaine M.
name: Shannon, Ryan
name: Tejos, Nicolas
name: Thorne, Jessica E.
name: Wang, Jing
name: Wayth, Randall
Publisher: name: Swinburne
Year: 2024

description: The putative host galaxy of FRB 20171020A was first identified as ESO 601-G036 in 2018, but as no repeat bursts have been detected, direct confirmation of the host remains elusive. In light of recent developments in the field, we re-examine this host and determine a new association confidence level of 98%. At 37 Mpc, this makes ESO 601-G036 the third closest FRB host galaxy to be identified to date and the closest to host an apparently non-repeating FRB (with an estimated repetition rate limit of
Geodätische Aspekte von Höhen und Höhenänderungen der Pegel und Pegelfestpunkte im Küstenbereich
Creators: name: Weiß, Robert
Publisher: name: Bundesanstalt für Gewässerkunde, Koblenz
Year: 2012
Subjects: subject: Water resources research

description: Hydrologie und Wasserbewirtschaftung / BfG – Jahrgang: 56.2012,5 - ISSN 1439-1783
Lateral Torsional Buckling of Wooden Beam-deck Systems
Creators: name: Du, Yang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Lateral torsional buckling
Wooden beam-deck system
Closed-form solution
Energy-based solution
Finite element formulation

description: A theoretical study is conducted for the lateral torsional buckling of wooden beam-deck assemblies consisting of twin beams braced by tongue-and-groove decking at the top. Two models are developed, each with a series of analytical and numerical solutions formulated. The first model targets twin-beam-deck assemblies where deck boards and other components are detailed to provide full continuous lateral restraint while the second model is built for situations where the beams are allowed to sway laterally and the relative lateral movement between the beams is partially restrained by the deck boards. In the first model, focus is on wind uplift while in the second model, both gravity and uplift loading scenarios are investigated. In the first model, an energy method is adopted and the principle of stationary potential energy is evoked to formulate closed-form solutions, energy-based solutions and a finite element solution. The validity of the present solutions is verified against a finite element based ABAQUS model. Similarly, a family of solutions is developed under the sway model and verified against the ABAQUS. Parametric studies are conducted for both models to examine the effects of various variables on the buckling capacity. A comparative investigation on the behavioral difference between the two models under ABAQUS is also presented. Overall, the restraining effects of deck boards bracing either on the beam compression or tension side is observed to have a significant influence on the lateral torsional buckling capacity of the twin-beam-deck assemblies.
The Scanpaths of Subjects with Developmental Prosopagnosia during a Face Memory Task
Creators: name: Lee, Dong-Ho
name: Corrow, Sherryse L.
name: Pancaroglu, Raika
name: Barton, Jason J. S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The scanpaths of healthy subjects show biases towards the upper face, the eyes and the center of the face, which suggests that their fixations are guided by a feature hierarchy towards the regions most informative for face identification. However, subjects with developmental prosopagnosia have a lifelong impairment in face processing. Whether this is reflected in the loss of normal face-scanning strategies is not known. The goal of this study was to determine if subjects with developmental prosopagnosia showed anomalous scanning biases as they processed the identity of faces. We recorded the fixations of 10 subjects with developmental prosopagnosia as they performed a face memorization and recognition task, for comparison with 8 subjects with acquired prosopagnosia (four with anterior temporal lesions and four with occipitotemporal lesions) and 20 control subjects. The scanning of healthy subjects confirmed a bias to fixate the upper over the lower face, the eyes over the mouth, and the central over the peripheral face. Subjects with acquired prosopagnosia from occipitotemporal lesions had more dispersed fixations and a trend to fixate less informative facial regions. Subjects with developmental prosopagnosia did not differ from the controls. At a single-subject level, some developmental subjects performed abnormally, but none consistently across all metrics. Scanning distributions were not related to scores on perceptual or memory tests for faces. We conclude that despite lifelong difficulty with faces, subjects with developmental prosopagnosia still have an internal facial schema that guides their scanning behavior.
Depression - die unterschätzte Volkskrankheit
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2022

description: Das Krankheitsbild Depression galt lange Zeit als Tabu. Auch wenn sich dieses Tabu langsam löst, ist es noch immer nicht für alle Betroffenen selbstverständlich, sich Hilfe zu holen. Über die unterschätzte Volkskrankheit spricht Harald Asel mit seinen Gästen. Quelle: www.inforadio.de
A mutagenesis study of the chicken low density lipoprotein receptor-related protein.
Creators: name: Kohen Avramoglu, Rita.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Biology, Molecular.

description: The low density lipoprotein receptor-related protein (LRP) is a 600 kDa endocytic plasma membrane receptor. LRP is involved in the uptake of numerous structurally and functionally unrelated ligands, including alpha2-macroglobulin:protease complexes (alpha2M*), apolipoprotein E-enriched remnant lipoproteins, Pseudomonas exotoxin A (PEA), and receptor associated protein (RAP). To date, analysis of LRP ligand-binding regions has proven challenging due to its large size and repeating modular structure. Using a recombinant DNA approach, full-length somatic chicken LRP, as well as several deletion mutants, were stably expressed in a mutant CHO-derived cell line deficient in endogenous LRP expression. LRP100, LRP67 and LRP25 encode 100%, 67% and 25% of the protein respectively, with LRP67 and LRP25 encoding large internal deletions but retaining an N-terminal portion, transmembrane region, and cytoplasmic tail. These three mutants were found to possess varying degrees of ligand-binding activity toward alpha 2M*, RAP, and PEA. Generation of this expression system has allowed the mapping of several LRP ligands to the N-terminal portion of the receptor and should allow further study of domains within LRP responsible for its multifunctionality. It was recently postulated that eight spacer regions within LRP containing repeating YWTD motifs adopt beta-propeller conformations. While developing cell, lines expressing refined mutants encoding deletions of putative ligand-binding regions, disruption of the naturally occurring, ordered arrangement of beta-propeller domains was found to have an effect on intracellular trafficking and plasma membrane presentation of mutant receptors. Although highly expressed, several mutants possessing crippled beta-propellers were not detected at the plasma membrane by biotin labeling. These mutants also exhibited delayed or no resistance to endoglycosidase H (endo H) suggesting ER exit was delayed or impaired. Restoration of integral beta-propellers and flanking EGF modules restored ER exit and plasma membrane presentation to a transport incompetent mutant. The beta-propeller domains may play an important role in conferring structural stability to LRP. Caution should therefore be exercised in the mutagenesis of this enormous receptor.
Supplementary document for Enhanced Radiative and Thermal Properties from Surface Encapsulation of InAs Nanowires - 5045724.pdf
Creators: name: Li, Xinxin
name: Walhof, Alexander
name: Dai, Weitao
name: Arslan, Ilke
name: Liu, Yuzi
name: Toor, Fatima
name: Prineas, John
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Information
On the origin of radio emission in the x-ray states of XTE J1650-500 during the 2001-2002 outburst
Creators: name: Corbel, Stéphane
name: Fender, Robert P.
name: Tomsick, J. A.
name: Tzioumis, Anastasios K.
name: Tingay, Steven J.
Publisher: name: Swinburne
Year: 2024

description: We report on simultaneous radio and X-ray observations of the black hole candidate XTE J1650-500 during the course of its 2001-2002 outburst. The scheduling of the observations allowed us to sample the properties of XTE J1650-500 in different X-ray spectral states, namely, the hard state, the steep power-law state, and the thermal dominant state, according to the recent spectral classification of McClintock & Remillard. The hard state is consistent with a compact jet dominating the spectral energy distribution at radio frequencies; however, the current data suggest that its contribution as direct synchrotron emission at higher energies may not be significant. In that case, XTE J1650-500 may be dominated by Compton processes (either inverse Comptonization of thermal disk photons and/or synchrotron self-Compton radiation from the base of the compact jet) in the X-ray regime. We surprisingly detect a faint level of radio emission in the thermal dominant state that may be consistent with the emission of previously ejected material interacting with the interstellar medium, similar (but on a smaller angular scale) to what was observed in XTE J1550-564 by Corbel and coworkers. Based on the properties of radio emission in the steep power-law state of XTE J1650-500 and taking into account the behavior of other black hole candidates (namely, GX 339-4, XTE J1550-564, and XTE J1859+226) while in the intermediate and steep power-law states, we are able to present a general pattern of behavior for the origin of radio emission in these two states that could be important for understanding the accretion-ejection coupling very close to the black hole event horizon.
Comparative Evaluation of Top-Down GOSAT XCO2 vs. Bottom-Up National Reports in the European Countries
Creators: name: Hwang, Youngseok
name: Schlüter, Stephan
name: Choudhury, Tanupriya
name: Um, Jung-Sup
Publisher: name: Technische Hochschule Ulm
Year: 2021
Subjects: subject: top–down
subject: bottom–up
subject: GOSAT XCO2
subject: national inventory report
subject: carbon footprint
subject: MRV
subject: DDC 620 / Engineering & allied operations

description: Submitting national inventory reports (NIRs) on emissions of greenhouse gases (GHGs) is obligatory for parties of the United Nations Framework Convention on Climate Change (UNFCCC). The NIR forms the basis for monitoring individual countries’ progress on mitigating climate change. Countries prepare NIRs using the default bottom–up methodology of the Intergovernmental Panel on Climate Change (IPCC), as approved by the Kyoto protocol. We provide tangible evidence of the discrepancy between official bottom–up NIR reporting (unit: tons) versus top–down XCO2 reporting (unit: ppm) within the European continent, as measured by the Greenhouse Gases Observing Satellite (GOSAT). Bottom–up NIR (annual growth rate of CO2 emission from 2010 to 2016: −1.55%) does not show meaningful correlation (geographically weighted regression coefficient = −0.001, R2 = 0.024) to top–down GOSAT XCO2 (annual growth rate: 0.59%) in the European countries. The top five countries within the European continent on carbon emissions in NIR do not match the top five countries on GOSAT XCO2 concentrations. NIR exhibits anthropogenic carbon-generating activity within country boundaries, whereas satellite signals reveal the trans-boundary movement of natural and anthropogenic carbon. Although bottom–up NIR reporting has already gained worldwide recognition as a method to track national follow-up for treaty obligations, the single approach based on bottom–up did not present background atmospheric CO2 density derived from the air mass movement between the countries. In conclusion, we suggest an integrated measuring, reporting, and verification (MRV) approach using top–down observation in combination with bottom–up NIR that can provide sufficient countrywide objective evidence for national follow-up activities.
FIGSHARE-PROTOCOL OF A SYSTEMATIC REVIEW.docx
Creators: name: Chambergo-Michilot, Diego
name: Tauma-Arrué, Astrid
name: Loli-Guevara, Silvana
Publisher: name: figshare
Year: 2020
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: We are uploading the protocol of a systematic review entitled: "Effectiveness and safety of sodium–glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis". The format of this protocol is as PROSPERO states.
Speaking the unspoken: the ontology of writing a novel
Creators: name: Colbert, Elizabeth Dianne
Publisher: name: Swinburne
Year: 2024

description: Creative practitioners, undertaking practice-led research, theorise their practice within an academic domain. Within a three-tiered, performative research paradigm, this project researched writerly identity during the writing of a novel and exegesis. Firstly, based on the writer's experience with creative and academic writing, the differences were explored through two first-person narratives in a frametale novel, The Fragility Papers, a process documented by critical and reflective journaling. Secondly, the insights gained during the writing of the novel were theorised within the domain of creative writers. Thirdly, the understandings embedded in the novel were considered in the light of these insights and those gained during writing of the exegesis and further theorised within the areas of voice, the writing process and ontological change. Novel writing, it was found, drew not only on the imagination, research, in-flow stream of consciousness writing and serendipitous occurrences but also on personal embodied inscriptions, linguistic play, logic and reason in the development of narrative coherence, forward planning, previously unidentified editing values based in the sonority of language, and a knowledge of the expectations associated with the literary genre. Acknowledging this breadth of experience led to changes in the writer's creative-writing process, a questioning of the theorised sole influence of language based texts as proposed in intertextual theory, and the proposal to italicise 'text' within intertextual to accommodate this breadth. The theorising of insights and emerging, experiential knowledge during the writing of the exegesis was realised in a series of evolving drafts in which interiorised knowledge was increasingly drawn upon in stream of consciousness writing. Further, in both genres, the dialogic engagement of the writer in conscious and unconscious activity at different stages of the writing process was found, suggesting that unconscious activity has a larger than envisaged role to play in academic writing.
Is climate change responsible for local changes in passerine abundance in North America?
Creators: name: Sendel, Tania Teresa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Ecology.

description: Human impacts such as habitat loss, species invasions and climate change are thought to be leading to biodiversity losses. However. little is known about the relative magnitudes of these effects. The purpose of this study is to determine to what extent climate change may have been responsible for observed changes in avian species' abundances. I investigated this question using data from the North American Breeding Bird Survey, one of the largest and most comprehensive biodiversity databases available. I found that 40% of the bird populations studied show significant linear changes in abundance from 1970 to 1999. Over the same period, temperature shows significant linear chances at 13% of the survey routes studied, whereas precipitation does not show significant trends. I analyzed the spatial relationships between abundance and climate and found that they are not strong (median R 2 = 0.119) but are generally consistent through time. Temporal trends in abundance were only very weakly related to trends in either temperature or temperature sub-optimality from 1970 to 1999. I found that temperature change is spatially autocorrelated over very long distances, whereas abundance change is autocorrelated over much shorter distances. Observed abundance changes in bird abundance are more likely to reflect local processes such as habitat modification.
Multiplexed Quantitative Proteomics Provides Mechanistic Cues for Malaria Severity and Complexity
Creators: name: Vipin Kumar
Publisher: name: Zenodo
Year: 2020

description: Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients. We identified a few parasite proteins in severe malaria patients, which could be promising from a diagnostic perspective. Further, from host proteome analysis we observed substantial modulations in many crucial physiological pathways, including lipid metabolism, cytokine signaling, complement, and coagulation cascades in severe malaria. We propose that severe manifestations of malaria are possibly underpinned by modulations of the host physiology and defense machinery, which is evidently reflected in the plasma proteome alterations. Importantly, we identified multiple blood markers that can effectively define different complications of severe falciparum malaria, including cerebral syndromes and severe anemia. The ability of our identified blood markers to distinguish different severe complications of malaria may aid in developing new clinical tests for monitoring malaria severity. 