cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Repulsion and attraction in high Tc superconductors
Creators: name: LiMing, W.
name: Chen, Haibo
name: Hu, Liangbin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The influence of repulsion and attraction in high-Tc superconductors to the gap functions is studied. A systematic method is proposed to compute the gap functions using the irreducible representations of the point group. It is found that a pure s-wave superconductivity exists only at very low temperatures, and attractive potentials on the near shells significantly expand the gap functions and increase significantly the critical temperature of superconductivity. A strong on-site repulsion drives the $A_{1g}$ gap into a $B_{1g}$ gap. It is expected that superconductivity with the $A_{1g}$ symmetry reaches a high critical temperature due to the cooperation of the on-site and the next-nearest neighbor attractions.
description: 4 pages, 5figures
Ankylosing Spondylitis in a 33- years old man with Hypermobility Joints
Creators: name: Demirtzoglou, Georgios
name: Theodorou, Evangelos
name: Klagou, Anastasia
name: Zervos, Nikolaos
name: Ampatziadis, Efstathios
Publisher: name: Aristotle Biomedical Journal
Year: 2020
Subjects: Ankylosing Spondylitis, Ehlers Danlos Syndrome, Joint Hypermobility

description: Background: Ankylosing spondylitis, is a chronic inflammatory autoimmune disease that mainly affects spine joints. It can cause severe, chronic pain, spine fusion and chronic disability. Ehlers-Danlos syndrome is a rare heterogenous group of hereditary connective tissue disorders which are characterized by skin hyperextensibility, joint hypermobility and tissue fragility. Case report: A 33-year old man was admitted to the Rheumatology Department of 251 Airforce General Hospital in order to decide on his capability to serve his duty as an aircraftsman at Hellenic Airforce. He was diagnosed with ankylosing spondylitis twelve years ago. On physical examination joint hypermobility and skin hyperextensibility were observed and after further investigation, he was diagnosed with hypermobility type of Ehlers Danlos Syndrome. Laboratory investigation was normal. MRI radiologic investigation revealed bony sclerosis of the left sacroiliac joint and bone marrow oedema on right sacroiliac joint. No extraskeletal manifestations were detected. The patient was informed about both conditions and he was given medical advice about their proper management. Conclusion: Rare diseases sometimes manifest as atypical inflammatory arthritis syndromes. Careful medical history, thorough physical examination and use of diagnostic criteria are useful in such patients for disease identification and treatment.
description: Aristotle Biomedical Journal, Vol 2, No 2 (2020)
Following the song of k’aad ‘aww (Dogfish Mother) : adolescent perspectives on English 10 First Peoples, writing, and identity
Creators: name: Davidson, Sara Florence
Publisher: name: University of British Columbia
Year: 2016

description: The purpose of this study was to explore how identity texts and narrative writing could strengthen adolescents’ writing and support adolescents’ identity explorations. The study took place in an English 10 First Peoples class in a small, remote community in northern British Columbia. The context was highly unique; therefore, the study also includes findings regarding the students’ and community’s response to a compulsory course with Indigenous content, the struggles for educators teaching the course, and the perceived strengths of the course. This qualitative case study (Stake, 1995) was guided by the metaphor of the Haida dogfish mother. It drew upon Indigenous storywork principles (Archibald, 2008) to create an ethical framework that extended beyond institutional standards for ethical conduct in research. This merging of methodologies invited improvisation, dialogue, and inner reflection to explore the role of stories, ancestry, history, and lived experiences in this research. Indigenous and non-Indigenous students, teachers, administrators, community members, and a parent were interviewed and observations were conducted in the English 10 First Peoples classroom, and the data were analyzed using the iterations of the k’aad ‘aww dance. The findings from this study indicated that adolescents generally engage more with writing that is based on topics of their choice and personal experiences. The adolescents shared ways that writing transformed their lives and strengthened their relationships. They also appreciated the inclusion of non-writing activities in their English language arts class. In this study, the resistance to English 10 First Peoples as a required course resulted in racially discriminatory conversations. These suggest the need to further explore ways to ensure all students and educators have access to accurate and respectful Indigenous content and history and to ensure that educators are not engaging in a racism of low expectations (Auditor General of British Columbia, 2015). The educators offered suggestions for improved support for courses that are rich in Indigenous content and pedagogical practices; overall they expressed that the strengths of the course far outweighed the struggles. All of the participants in this study emphasized the importance of building strong relationships between students and educators.
Feasibility and early clinical impact of precision medicine for late-stage cancer patients in a regional public academic hospital
Creators: name: Ladekarl, Morten
name: Nøhr, Anne Krogh
name: Sønderkær, Mads
name: Dahl, Simon Christian
name: Sunde, Lone
name: Vesteghem, Charles
name: Mapendano, Christophe Kamungu
name: Haslund, Charlotte Aaquist
name: Pagh, Anja
name: Carus, Andreas
name: Lörincz, Tamás
name: Nowicka-Matus, Kinga
name: Poulsen, Laurids Ø.
name: Laursen, René Johannes
name: Dybkær, Karen
name: Poulsen, Birgitte Klindt
name: Frøkjær, Jens Brøndum
name: Brügmann, Anja Høegh
name: Ernst, Anja
name: Wanders, Alkwin
name: Bøgsted, Martin
name: Pedersen, Inge Søkilde
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Virology
subject: Computational Biology

description: Our goal was to describe a precision medicine program in a regional academic hospital, characterize features of included patients and present early data on clinical impact. We prospectively included 163 eligible patients with late-stage cancer of any diagnosis from June 2020 to May 2022 in the Proseq Cancer trial. Molecular profiling of new or fresh frozen tumor biopsies was done by WES and RNAseq with parallel sequencing of non-tumoral DNA as individual reference. Cases were presented at a National Molecular Tumor Board (NMTB) for discussion of targeted treatment. Subsequently, patients were followed for at least 7 months. 80% (N = 131) of patients had a successful analysis done, disclosing at least one pathogenic or likely pathogenic variant in 96%. A strongly or potentially druggable variant was found in 19% and 73% of patients, respectively. A germline variant was identified in 2.5%. Median time from trial inclusion to NMTB decision was one month. One third (N = 44) of patients who underwent molecularly profiling were matched with a targeted treatment, however, only 16% were either treated (N = 16) or are waiting for treatment (N = 5), deteriorating performance status being the primary cause of failure. A history of cancer among 1st degree relatives, and a diagnosis of lung or prostate cancer correlated with greater chance of targeted treatment being available. The response rate of targeted treatments was 40%, the clinical benefit rate 53%, and the median time on treatment was 3.8 months. 23% of patients presented at NMTB were recommended clinical trial participation, not dependent on biomarkers. Precision medicine in end-stage cancer patients is feasible in a regional academic hospital but should continue within the frame of clinical protocols as few patients benefit. Close collaboration with comprehensive cancer centers ensures expert evaluations and equality in access to early clinical trials and modern treatment.
Verlauf der meteorologischen Elemente im oberen Donaugebiet im Zeitraum 1889-1928 und ihre Beziehungen zur Donauversinkung
Creators: name: Troßbach, Gustav
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1932

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 88, 1932
A simulation toolkit for electroluminescence assessment in rare event experiments
Creators: name: Oliveira, C. A. B.
name: Schindler, H.
name: Veenhof, R.
name: Biagi, S.
name: Monteiro, C. M. B.
name: Santos, J. M. F. dos
name: Ferreira, A. L.
name: Veloso, J. F. C. A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A good understanding of electroluminescence is a prerequisite when optimising double-phase noble gas detectors for Dark Matter searches and high-pressure xenon TPCs for neutrinoless double beta decay detection. A simulation toolkit for calculating the emission of light through electron impact on neon, argon, krypton and xenon has been developed using the Magboltz and Garfield programs. Calculated excitation and electroluminescence efficiencies, electroluminescence yield and associated statistical fluctuations are presented as a function of electric field. Good agreement with experiment and with Monte Carlo simulations has been obtained.
Venlafaxine’s effect on human genetic material: in vitro study
Creators: name: Demirtzoglou, Georgios
name: Chrysoglou, Sofia Ifigeneia
name: Goula, Maria
name: Iakovidou – Kritsi, Zafeiroula
name: Garyfallos, Alexandros
name: Lambropoulos, Alexandros
Publisher: name: Aristotle Biomedical Journal
Year: 2020
Subjects: Venlafaxine, Cytogenetic Activity, Sister Chromatid Exchanges, Proliferation Rate Index, Mitotic Index.

description: Introduction: Venlafaxine is a prescription drug approved for the treatment of major depressive disorder, generalized anxiety disorder, panic disorder and social anxiety disorder. It is a serotonin and norepinephrine reuptake inhibitor and a weak dopamine reuptake inhibitor. The aim of the present study is to investigate the in vitro effect of venlafaxine on human genetic material, by estimating sensitive cytogenetic indices. Methods: Five venlafaxine solutions (A=15μg/ml, B=30μg/ml, C=45μg/ml, D=60μg/ml, E=75μg/ml) were added to cultures of peripheral blood lymphocytes of six healthy donors. After 72 hours of incubation, the cultured lymphocytes were plated on glass slides, stained with the Fluorescence plus Giemsa method and Sister Chromatid Exchanges (SCEs), a sensitive marker of genotoxicity, Proliferation Rate Index (PRI), a reliable marker of cytostatic activity and Mitotic Index (MI), a marker which shows precisely the ability of a cell to proliferate were measured with the optical microscope. Results: Result analysis revealed t: a) a statistically significant (p=0.001) dose-dependent increase of SCEs and b) a statistically significant (p=0.001) reduction of PRI and MI in all concentrations. Furthermore, a correlation was observed between a) SCE and PRI index variations, b) MI and SCE index variations and c) PRI and MI index variations. Conclusions: Venlafaxine exhibited dose-dependent cytogenetic activity in vitro, increasing SCE frequencies and diminishing PRI and MI levels in healthy human cultured lymphocytes. Venlafaxine as other antidepressants seems to affect human T lymphocytes by modifying epigenetic and DNA replication procedures. This may provide additional information about the mechanism of action of the drug. Considering that the use of venlafaxine has rapidly increased with many off label indications, further studies in other cell lines and in vivo experimental settings are needed in order to evaluate its potential effects on human genetic material.
description: Aristotle Biomedical Journal, Vol 2, No 2 (2020)
Dehnrheologie verdünnter, halbkonzentrierter und konzentrierter Polymerlösungen untersucht mit Capillary Breakup Extensional Rheometry (CaBER)
Creators: name: Arnolds, Oliver
Publisher: name: Karlsruhe
Year: 2011
Subjects: Dehnviskosität
CaBER
Polymerlösungen
Acrylatverdicker

description: Ziel dieser Arbeit war es, die dehnrheologischen Eigenschaften von technisch relevanten, niederviskosen Polymerlösungen zu bestimmen. Die Messungen wurden am CaBER ? Gerät durchgeführt, das zu diesem Zweck um einen optischen Aufbau erweitert sowie um die Möglichkeit der Kraftmessung bei horizontaler Verstreckung ergänzt wurde. So war es möglich, an den untersuchten Systemen die absolute Dehnviskosität zu bestimmen und aus Referenzschermessungen das Trouton ? Verhältnis zu ermitteln.
Metastasis-associated C4.4A acts as a linker between membrane proteases and alpha6beta4
Creators: name: Ngora, Honoré
Publisher: name: Karlsruhe
Year: 2011
Subjects: Cancer
C4.4A
metastasis
membrane proteases
hypoxia

description: C4.4A is a metastasis-associated membrane proteins. Its expression is very restricted on normal tissue, but strongly upregulated during wound healing and progression in some tumors. The function of the molecule still remaining elusive, I aimed to shed some light on its transcriptional regulation and possible functions. Although C4.4A transcription is not promoted by HIF-1alpha, increase C4.4A expression under hypoxia supports motility, invasiveness and apoptosis resistance.
Die chemischen Bestandteile der Mineralquelle beim Mathildenhof in Ludwigsburg
Creators: name: Frank, Manfred
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1932

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 88, 1932
The role of values and emotions in patients’ health care decision-making
Creators: name: Voultsos, Polychronis
Publisher: name: Aristotle Biomedical Journal
Year: 2021
Subjects: Values; emotions; decision-making process; practical wisdom; narrative identity.

description: Aim: As the decision-making science progresses, in recent years, there has been an increasing discussion about non-cognitive components involved in decision-making process. This paper aims to provide an inclusive overview of current knowledge on the state of the science related to the role of values and emotions in decision making. In an effort to provide the most inclusive review possible, internal rationality, awareness of values, and practical wisdom will be considered. Method: It was conducted a comprehensive narrative review of literature on the topic of interest. Results: Sharp distinction between rational and emotional decisions would be a false dichotomy. Both values and emotions underpin every aspect of a decision-making process. Interpersonal comparisons of value judgments are thought of as being inherent in the very activity of interpretation. This is important when considering reasonableness of another’s decision. Moreover, as decision-makers has to be aware of and then navigate their own, feelings and values, it is noticeable that emotions may not only affect the development of the values of an individual, but also affect an individual’s introspective awareness of her values, beliefs and preferences. Finally, it is interesting to note that it has been suggested an alternative approach to decision-making competence based on decision-maker’s practical wisdom. Conclusion: The ways by which beliefs, values, and emotions affect decision-making processes seem to be unclear and overlapping, thus giving a boost to uncertainties. Further research into complexities related to the role of values and emotions in decision making seems to be necessary.
description: Aristotle Biomedical Journal, Vol 3, No 1 (2021)
Scaling Relations for Watersheds
Creators: name: Fehr, E.
name: Kadau, D.
name: Araújo, N. A. M.
name: Andrade, J. S.
name: Herrmann, H. J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computational Physics (physics.comp-ph)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: We study the morphology of watersheds in two and three dimensional systems subjected to different degrees of spatial correlations. The response of these objects to small, local perturbations is also investigated with extensive numerical simulations. We find the fractal dimension of the watersheds to generally decrease with the Hurst exponent, which quantifies the degree of spatial correlations. Moreover, in two dimensions, our results match the range of fractal dimensions $1.10 \leq d_f \leq 1.15$ observed for natural landscapes. We report that the watershed is strongly affected by local perturbations. For perturbed two and three dimensional systems, we observe a power-law scaling behavior for the distribution of areas (volumes) enclosed by the original and the displaced watershed, and for the distribution of distances between outlets. Finite-size effects are analyzed and the resulting scaling exponents are shown to depend significantly on the Hurst exponent. The intrinsic relation between watershed and invasion percolation, as well as relations between exponents conjectured in previous studies with two dimensional systems, are now confirmed by our results in three dimensions.
Perturbation Dynamics and Impact of Different Perturbation Methods in Tropical Cyclone Ensemble Forecasting
Creators: name: Lang, Simon
Publisher: name: Karlsruhe
Year: 2011
Subjects: Tropical Cyclones
Stochastis Physics
Ensemble Forecasting
Year of Tropical Convection
Singular Vectors

description: Ensemble forecasts are used to quantify the uncertatinty that is associated with a single weather forecast. In the ensemble prediction system of the European Centre for Medium-Range Weather Forecasts different perturbation methods are applied to account for uncertainties associated with the initial conditions and the forecast model. In this study, the impact of the different methods on tropical cyclone forecasts is analysed and the growth mechanisms of the perturbations are identified.
Sedimentdruck und seine Beziehung zum Fossil
Creators: name: Klähn, Hans
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1932

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 88, 1932
Performance Comparison of SVM and ANN for Handwritten Devnagari Character Recognition
Creators: name: Arora, Sandhya
name: Bhattacharjee, Debotosh
name: Nasipuri, Mita
name: Malik, L.
name: Kundu, M.
name: Basu, D. K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Classification methods based on learning from examples have been widely applied to character recognition from the 1990s and have brought forth significant improvements of recognition accuracies. This class of methods includes statistical methods, artificial neural networks, support vector machines (SVM), multiple classifier combination, etc. In this paper, we discuss the characteristics of the some classification methods that have been successfully applied to handwritten Devnagari character recognition and results of SVM and ANNs classification method, applied on Handwritten Devnagari characters. After preprocessing the character image, we extracted shadow features, chain code histogram features, view based features and longest run features. These features are then fed to Neural classifier and in support vector machine for classification. In neural classifier, we explored three ways of combining decisions of four MLP's designed for four different features.
Sarcopenia and loss of muscle mass in patients with lung cancer undergoing chemotherapy treatment: a systematic review and meta-analysis
Creators: name: Jensen, Sandra
name: Bloch, Zina
name: Quist, Morten
name: Hansen, Tobias Tuse Dunk
name: Johansen, Christoffer
name: Pappot, Helle
name: Suetta, Charlotte
name: Rafn, Bolette Skjødt
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: In patients with cancer, sarcopenia is associated with treatment related complications, treatment cessation, poor quality of life and reduced overall survival. Despite this, there is limited knowledge about changes in skeletal muscle mass during chemotherapy. The aim of this systematic review and meta-analysis was to investigate the change of skeletal muscle mass and sarcopenia during chemotherapy treatment among patients with lung cancer. A systematic literature search was conducted in three databases, PubMed, EMBASE and Web of Science. Observational studies with patients with lung cancer were eligible for inclusion if skeletal muscle mass was measured before and after receiving chemotherapy treatment. Ten cohort studies with a total of 867 participants met the inclusion criteria. During 5.2 ± 2.9 months of chemotherapy treatment, patients with lung cancer experienced a significant loss of skeletal muscle mass with a standardized mean difference (SMD) of: -0.25 (95% CI -0.47 to -0.03). The pretreatment prevalence of sarcopenia varied across studies from 35% to 74%. Only one study reported prevalence of sarcopenia both before and after chemotherapy treatment with an increase from 35% to 59%. The present data demonstrate a marked loss of skeletal muscle mass in patients with lung cancer undergoing chemotherapy treatment, as well as a high prevalence of sarcopenia. As sarcopenia is associated with poor clinical outcomes, it seems important to include and use assessments of skeletal muscle mass in clinical practice to identify patients in need for interventions. Moreover, interventional studies to hinder development of sarcopenia are needed.
Decision Maps for Distributed Scenario-Based Multi-Criteria Decision Support
Creators: name: Comes, Martina
Publisher: name: Karlsruhe
Year: 2011
Subjects: Robust Decision Support
Scenario-Based Reasoning
Multi-Criteria Decision Support
Distributed Scenario Generation

description: This thesis presents the Decision Map approach to support decision-makers facing complex uncertain problems that defy standardised solutions. First, scenarios are generated in a distributed manner: the reasoning processes can be adapted to the problem at hand whilst respecting constraints in time and availability of experts. Second, by integrating scenarios and MCDA, this approach facilitates robust decision-making respecting multiple criteria in a transparent well-structured manner.
Effects of Fermented Nano Chinese Herbal Medicines Replacing Antibiotics on Production Performance and Carcass Quality of Growing-Finishing Pigs
Creators: name: HU Yongling
name: NGUYEN, Thi Thanh Hai
name: CHEN Xi
name: ZOU Zhenxing
name: ZHONG Jinfeng
name: HU Yongling
name: NGUYEN, Thi Thanh Hai
name: CHEN Xi
name: ZOU Zhenxing
name: ZHONG Jinfeng
Publisher: name: Unknown
Year: 2021
Subjects: subject: Agribusiness
subject: Growing-finishing pigs, Fermented nano Chinese herbal medicine preparation, Production performance, Carcass quality

description: [Objectives] To study the effects of fermented nano Chinese herbal medicines replacing antibiotics on the production performance and carcass quality of growing-finishing pigs. [Methods] 200 healthy and disease-free Duroc-Landrace-Yorkshire (DLY) growing-finishing pigs with similar birth time (45 ± 2 d) and body weight of about 31.5 kg were randomly divided into group A (fed with non-antibiotic basal diet), group B (fed with antibiotic basal diet), group C (fed with non-antibiotic basal diet + 0.1% fermented nano Chinese herbal medicine preparation), group D (fed with non-antibiotic basal diet + 0.3% fermented nano Chinese herbal medicine preparation) and group E (fed with non-antibiotic basal diet + 0.5% fermented nano Chinese herbal medicine preparation). The experiment lasted for 90 d. At the end of the experiment, the production performance and carcass indicators were measured. [Results] Compared with group A, the final weight, average daily gain (ADG) and average daily feed intake (ADFI) of groups B, C, D and E were extremely significantly increased (P＜ 0.01), while the feed-to-gain ratio (F/G) was extremely significantly decreased (P＜ 0.01). Compared with group B, the ADG of group E was significantly increased (P＜0.05), while the F/G was significantly decreased (P＜ 0.05). Compared with group A, the slaughter rate and carcass length of pigs in groups B, C, D and E were extremely significantly increased (P＜0.01); compared with group B, the slaughter rate of groups D and E was extremely significantly increased (P＜0.01). [Conclusions] The fermented nano Chinese herbal medicine preparation has better effects in promoting growth are better than that of antibiotic additives, and it can significantly improve the carcass quality of growing-finishing pigs.
Feasibility and early clinical impact of precision medicine for late-stage cancer patients in a regional public academic hospital
Creators: name: Ladekarl, Morten
name: Nøhr, Anne Krogh
name: Sønderkær, Mads
name: Dahl, Simon Christian
name: Sunde, Lone
name: Vestereghem, Charles
name: Mapendano, Christophe Kamungu
name: Haslund, Charlotte Aaquist
name: Pagh, Anja
name: Carus, Andreas
name: Lörincz, Tamás
name: Nowicka-Matus, Kinga
name: Poulsen, Laurids Ø.
name: Laursen, René Johannes
name: Dybkær, Karen
name: Poulsen, Birgitte Klindt
name: Frøkjær, Jens Brøndum
name: Brügmann, Anja Høegh
name: Ernst, Anja
name: Wanders, Alkwin
name: Bøgsted, Martin
name: Pedersen, Inge Søkilde
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Virology
subject: Computational Biology

description: Our goal was to describe a precision medicine program in a regional academic hospital, characterize features of included patients and present early data on clinical impact. We prospectively included 163 eligible patients with late-stage cancer of any diagnosis from June 2020 to May 2022 in the Proseq Cancer trial. Molecular profiling of new or fresh frozen tumor biopsies was done by WES and RNAseq with parallel sequencing of non-tumoral DNA as individual reference. Cases were presented at a National Molecular Tumor Board (NMTB) for discussion of targeted treatment. Subsequently, patients were followed for at least 7 months. 80% (N = 131) of patients had a successful analysis done, disclosing at least one pathogenic or likely pathogenic variant in 96%. A strongly or potentially druggable variant was found in 19% and 73% of patients, respectively. A germline variant was identified in 2.5%. Median time from trial inclusion to NMTB decision was one month. One third (N = 44) of patients who underwent molecularly profiling were matched with a targeted treatment, however, only 16% were either treated (N = 16) or are waiting for treatment (N = 5), deteriorating performance status being the primary cause of failure. A history of cancer among 1st degree relatives, and a diagnosis of lung or prostate cancer correlated with greater chance of targeted treatment being available. The response rate of targeted treatments was 40%, the clinical benefit rate 53%, and the median time on treatment was 3.8 months. 23% of patients presented at NMTB were recommended clinical trial participation, not dependent on biomarkers. Precision medicine in end-stage cancer patients is feasible in a regional academic hospital but should continue within the frame of clinical protocols as few patients benefit. Close collaboration with comprehensive cancer centers ensures expert evaluations and equality in access to early clinical trials and modern treatment.
Separable states to distribute entanglement
Creators: name: Park, Jeonghoon
name: Lee, Soojoon
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It was shown that two distant particles can be entangled by sending a third particle never entangled with the other two [T. S. Cubitt et al., Phys. Rev. Lett. 91, 037902 (2003)]. In this paper, we investigate a class of three-qubit separable states to distribute entanglement by the same way, and calculate the maximal amount of entanglement which two particles of separable states in the class can have after applying the way.
description: 4 pages, no figures, Revised argument
Influence of various assumptions for the individual TNM components on the TNM stage using Nordic cancer registry data
Creators: name: Engholm, Gerda
name: Lundberg, Frida E.
name: Kønig, Simon M.
name: Ólafsdóttir, Elínborg
name: Johannesen, Tom B.
name: Pettersson, David
name: Mørch, Lina S.
name: Johansson, Anna L. V.
name: Friis, Søren
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Statistics
subject: FOS: Mathematics

description: The stage at diagnosis is one of the most important predictors for cancer survival. TNM stage is constructed from T (tumor size), N (nodal spread), and M (distant metastasis) components. In many notifications to cancer registries, TNM information is incomplete with unknown N and/or M. We aimed to evaluate the influence of various assumptions for recoding missing N (NX) and M (MX) as N0 and M0 on the proportion with available TNM stage, stage-distribution, and stage-specific relative survival. We identified 140,201 patients diagnosed with incident cancer of the colon, rectum, lung, breast, or kidney during 2014–2016 in Denmark, Norway, Sweden, or Iceland. Information on TNM were obtained from cancer registry records used for an update of the Nordic cancer statistics database NORDCAN. Patients were followed for death or emigration through 2017. We calculated proportions of available TNM stage, stage distribution, and stage-specific relative survival under different approaches for each cancer site and country. Application of the assumptions yielded higher numbers of cases with available TNM stage for stages 0–I, II, and III. We observed only minor differences in stage-specific one-year relative survival when applying N0M0 for missing N and M, especially for high completeness of TNM registrations, whereas relative survival for remaining cases with missing TNM stage declined substantially. We found no major changes in stage-specific one-year relative survival applying N0M0 for NXMX. We conclude that complete TNM information is preferable to making assumptions, but it seems reasonable to consider assuming N0M0 for missing N and M in future studies based on the Nordic cancer registries. An automatic algorithm, though, is not recommended without considering potential area-specific reasons for frequent use of NX and MX. Clinicians should be urged to report complete TNM information to improve surveillance of the TNM stage.
Die Foraminiferen aus den Transversarius-Schichten und Impressa-Tonen der nordöstlichen Schwäbischen Alb
Creators: name: Paalzow, Richard
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1932

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 88, 1932
Radon induced background processes in the KATRIN pre-spectrometer
Creators: name: Fränkle, F. M.
name: Bornschein, L.
name: Drexlin, G.
name: Glück, F.
name: Görhardt, S.
name: Käfer, W.
name: Mertens, S.
name: Wandkowsky, N.
name: Wolf, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The KArlsruhe TRItium Neutrino (KATRIN) experiment is a next generation, model independent, large scale tritium beta-decay experiment to determine the effective electron anti-neutrino mass by investigating the kinematics of tritium beta-decay with a sensitivity of 200 meV/c2 using the MAC-E filter technique. In order to reach this sensitivity, a low background level of 0.01 counts per second (cps) is required. This paper describes how the decay of radon in a MAC-E filter generates background events, based on measurements performed at the KATRIN pre-spectrometer test setup. Radon (Rn) atoms, which emanate from materials inside the vacuum region of the KATRIN spectrometers, are able to penetrate deep into the magnetic flux tube so that the alpha-decay of Rn contributes to the background. Of particular importance are electrons emitted in processes accompanying the Rn alpha-decay, such as shake-off, internal conversion of excited levels in the Rn daughter atoms and Auger electrons. While low-energy electrons (< 100 eV) directly contribute to the background in the signal region, higher energy electrons can be stored magnetically inside the volume of the spectrometer. Depending on their initial energy, they are able to create thousands of secondary electrons via subsequent ionization processes with residual gas molecules and, since the detector is not able to distinguish these secondary electrons from the signal electrons, an increased background rate over an extended period of time is generated.
Emotions as parts of the inner lives of physicians in the modern clinical context
Creators: name: Voultsos, Polychronis
Publisher: name: Aristotle Biomedical Journal
Year: 2021
Subjects: Emotions; Physicians, Burnout; Decision making; Moral distress; Post-traumatic syndrome; Compassion fatigue

description: Aim: As physicians often struggle with devastating illness and loss, they often experience more or less intense emotions arising from the care of patients. As yet, however, little attention has been given to physicians’ emotional reactions. This paper aims at exploring the emotional reactions of physicians in the workplace as well as the impact of their emotions on their professionality and personal well-being. Method: A comprehensive narrative review of the currently available literature related to the topic of interest has been conducted placing considerable emphasis on the recently published sources. Results: Grief, sense of failure, frustration, feelings of powerlessness, death anxiety, self-blame or guilt, and a feeling of obligation to save the patient are among the most common emotions that physicians experience in the workplace. Importantly, while the relationship between physicians’ emotions and burnout, moral distress, medical communication, empathy, shared decision making and compassion fatigue seems to be to a greater or lesser extent correlative, it remains unclear in details. It is not easy for physicians to be engaged in identifying and controlling their emotional reactions in the workplace. Emotion recognition and regulation is of great importance for protecting physician’s professionality as well as professional and personal well-being. Conclusion: The physicians’ emotional reactions and the consequences of their emotions in the workplace is a complex and multifactorial topic that requires further exploration. Physicians’ emotional state may profoundly impact on the quality of their well-being and care delivery. Further education should be designed and strategies should be developed to increase physicians' ability to recognize and manage to cope with their unexamined emotional reactions.
description: Aristotle Biomedical Journal, Vol 3, No 1 (2021)
Approximate null distribution of the largest root in multivariate analysis
Creators: name: Johnstone, Iain M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: The greatest root distribution occurs everywhere in classical multivariate analysis, but even under the null hypothesis the exact distribution has required extensive tables or special purpose software. We describe a simple approximation, based on the Tracy--Widom distribution, that in many cases can be used instead of tables or software, at least for initial screening. The quality of approximation is studied, and its use illustrated in a variety of setttings.
description: Published in at http://dx.doi.org/10.1214/08-AOAS220 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Die Fauna von Württemberg. Käfer. (3. Fortsetzung)
Creators: name: Trappen, Arthur von der
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1932

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 88, 1932
ZnO-based thermoelectrics : modelling, electrochemical thick film growth, and characterization
Creators: name: Sielmann, Christoph
Publisher: name: University of British Columbia
Year: 2016

description: The thermoelectric performance of electrodeposited, aluminum doped zinc oxide was assessed. In this work, wurtzite ZnO was first modelled using Mueller-Plathe to compare the effectiveness of different nanostructured configurations on reducing thermal conductivity. A new analysis technique, Local Vibrational Density of States Equilibrium Molecular Dynamics (LVDOS-EMD), was created to study localized lattice vibrations around nanostructural features of silicon and ZnO, and was used to predict thermal properties in materials of similar composition 17× faster than conventional thermal modelling methods. A 30% void density was determined to yield the best reduction in thermal conductivity by volume of voids in bulk Al:ZnO with a computed thermal conductivity of 0.77 W m-¹ K-¹ at room temperature, 3× below the threshold achieved through established experimental means with high electrical conductivity Al:ZnO. Thick film, electrodeposited Al:ZnO was grown using a nitrate system. Experiments on solution pH using various counter electrodes demonstrated that inert electrodes caused acidification of the growth solution, limiting film thickness. Chloride contamination from commonly used Ag/AgCl reference electrodes was also determined to affect thick film opacity, morphology, crystallinity, and electrical properties. Aluminum integration and activation was explored by adding Al(NO₃)₃ to the growth solution during film synthesis, yielding aluminum integration molar ratios of up to 1.72% (Al.₀₃₄Zn.₉₆₆₀). Partially doped films in excess of 95 µm thick, 4× the thickness reported elsewhere, were electrochemically grown and characterized. Sub-micron voids were integrated into the films using sacrificial material and annealing. A new electrochemical chromium etching methodology was developed and successfully used to free 20 films from their growth substrates for thermoelectric characterization. A new, reusable thermoelectric test apparatus for thin film thermoelectric testing was designed, implemented, calibrated, and successfully deployed to characterize ZnO and Al:ZnO thin films grown 79 – 95 µm in thickness. Extremely low thermal conductivity of 11 mW m-¹ K-¹ at room temperature was demonstrated concurrently with a Seebeck coefficient of -88 µV K-¹. Polycrystallinity and poor dopant activation yielded a low electrical conductivity of 0.75 mS/cm and corresponding low room temperature ZT of 1.3×10-⁵ for the Al:ZnO films.
Overview of very small embryonic like stem cells (VSELs) and their therapeutic potential
Creators: name: Kakavoulia, Maria-Anthi
Publisher: name: Aristotle Biomedical Journal
Year: 2021
Subjects: VSELs, stem cells, regenerative medicine, tissue repair, organ repair, aging

description: In recent years, the progress of stem cell research along with the need for stem cell-based therapy, has brought researchers to focus on finding new stem cell populations, which hold advantages over the already known. For that reason, the ethical, histocompatibility and technological issues have led scientists to discover a new stem cell population, namely, very small embryonic like stem cells (VSELs). These cells were characterized as small-seized, quiescent with high nuclei/cytoplasmic ratio and open type euchromatin. The most significant property is that they express several pluripotent stem cells markers and demonstrate the ability to differentiate into three germ-layer lineages. A lot of studies have already been performed for murine VSELs, only a few for human VSELs and all the results demonstrate that these stem cells can regenerate a lot of tissues and organs and maybe they play an important role in aging. However, further clinical and research studies on these cells need to be performed in the following years. In this paper, we will emphasize on the properties of VSELs and we will examine the therapeutic potential and the advantages they may hold.
description: Aristotle Biomedical Journal, Vol 3, No 1 (2021)
Sales of Fluid Milk Products, 1954-72
Creators: name: Manchester, Alden C.
name: Manchester, Alden C.
Publisher: name: Unknown
Year: 1973
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Research Methods/ Statistical Methods
subject: Milk
subject: consumption
subject: marketing

description: New data are presented on sales of fluid milk products in the United States from 1954 through 1972. The data pertain to quantity and value of sales by producer-distributors and commercial processors, sales of individual products, butterfat content of fluid milk products, home delivery sales, and sales to away-from-home eating establishments. The methods by which these data were developed are also discussed.
Very Small Embryonic-Like Stem Cells (VSELs)
Creators: name: Kopsacheili, Anna
Publisher: name: Aristotle Biomedical Journal
Year: 2021
Subjects: very small embryonic-like stem cells (VSELs), pluripotent stem cells, morphology, developmental origin, molecular characteristics, mobilization of VSELs, potential application of VSELs

description: VSELs are an innovative and promising candidate which currently earns increasing attention and further investigation due to their capability to express different pluripotent markers and to differentiate into three lineages. These stem cells are a backup pool which are mainly mobilized after stress conditions and focus on tissue and organ regeneration without causing the formation of teratoma. The aim of this paper is to integrate different strands of research findings related to VSELs. Researches have shown that VSELs have a regenerative role in several organs and they can also contribute to decelerate aging processes. Further studies are recommended to be done on huVSELs in order to check thoroughly their rejuvenational potentials because the use of these stem cells is one of the most important challenges in the regenerative medicine.
description: Aristotle Biomedical Journal, Vol 3, No 1 (2021)
Global regularity for ordinary differential operators with polynomial coefficients
Creators: name: Nicola, Fabio
name: Rodino, Luigi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Analysis of PDEs (math.AP)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 35H10, 47E05, 35S05, 14H05

description: For a class of ordinary differential operators $P$ with polynomial coefficients, we give a necessary and sufficient condition for $P$ to be globally regular in $\R$, i.e. $u\in\cS^\prime(\R)$ and $Pu\in\cS(\R)$ imply $u\in \cS(\R)$ (this can be regarded as a global version of the Schwartz' hypoellipticity notion). The condition involves the asymptotic behaviour, at infinity, of the roots $ξ=ξ_j(x)$ of the equation $p(x,ξ)=0$, where $p(x,ξ)$ is the (Weyl) symbol of $P$.
description: 23 pages
Alcian Blue Histological investigation of generated hyaline cartilage tissue from adipose mesenchymal stem cells, on Polycaprolactone scaffolds.
Creators: name: Ftergioti, Argyro
name: Theodoridis, K.
name: Angelidou, E.
name: Manthou, M.
name: Kritis, A.
Publisher: name: Aristotle Biomedical Journal
Year: 2021
Subjects: Alcian Blue, hyaline cartilage, adipose mesenchymal stem cells, Polycaprolactone, scaffold

description: Purpose: Cartilage has a low regenerative capacity and research has recently focused on regenerative medicine and the construction of three-dimensional scaffolds for cartilage production. The aim of the study was to compare three types of polycaprolactone scaffolds (PCLs) and to characterize the produced cells as chondrocytes, using Alcian blue, a widespread histochemical staining. Methods: We manufactured polycaprolactone scaffolds with three different geometry patterns, named PCL1, PCL2 and PCL3. Adipose mesenchymal stem cells ADMSCs were harvested and were cultivated on all scaffolds. After 26 days of culture, scaffolds were histologically examined. Results: Chondrocytes and extracellular material in scaffolds were revealed by alcian blue staining. In all three types of scaffolds extracellular matrix high in proteoglycans was produced. Small cells were usually found in three-dimensional, tight groups. Larger cells were often identified in flat groups with more extracellular material. In PCL2 scaffolds, cells were usually more rounded and often appeared to be inside lacunae. Perichondrium was detected. Conclusion: Chondrogenesis was achieved in all three types of scaffolds. In all cases we identified cells at various stages of maturation. In the PCL2 scaffold, cells appeared more mature, suggesting that this type of scaffold may be a little more favorable for chondrogenesis.
description: Aristotle Biomedical Journal, Vol 3, No 1 (2021)
Very small embryonic-like (VSEL) stem cells: recent knowledge
Creators: name: Niti, Argyri
Publisher: name: Aristotle Biomedical Journal
Year: 2021
Subjects: very small embryonic-like stem cells (VSELs), primordial germ cells PGC, regeneration potential, isolation methods

description: Very small embryonic-like stem cells (VSELs) are a unique and rare stem cell population, which have the same structural, genetic, biochemical, and functional characteristics as embryonic stem cells and they are able to differentiate to all three germ layers. In several emergency situations related to organ damage, VSELs can be activated and mobilized into peripheral blood, and in appropriate animal models they contribute to tissue organ/regeneration. Optimized methods for isolation and expansion of VSELs have aroused the scientific community's interest in use of this kind of cells for regenerative purposes. The properties of such pluripotent cells make them a potential candidate in regenerative medicine.
description: Aristotle Biomedical Journal, Vol 3, No 1 (2021)