cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Contact resistance assessment and high-frequency performance projection of black phosphorus field-effect transistor technologies
Creators: name: Valdez-Sandoval, Leslie M.
name: Ramirez-Garcia, Eloy
name: Jiménez, David
name: Pacheco-Sanchez, Anibal
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this work, an evaluation of the contact quality of black phosphorus (BP) field-effect transistors (FETs) from different technologies previously reported is performed by means of an efficient and reliable contact resistance extraction methodology based on individual device practical characteristics. A good agreement is achieved between the extracted values with the Y-function method used here and reference values obtained with other methods considering internal values as well as with more expensive methods involving fabricated test structures. The method enables a direct evaluation of different steps in the same technology and it embraces the temperature dependence of the contact characteristics. Channel phenomena have no impact on the extracted contact resistance values. High-frequency performance projections are obtained for fabricated devices based on the extracted contact resistance.
Die menschliche Dimension der Konferenz für Sicherheit und Zusammenarbeit in Europa - ein Impuls für kirchliches Handeln
Creators: name: Müller, Peter
Publisher: name: Ökumenische Rundschau
Year: 2025

description: Ökumenische Rundschau, Bd. 38 Nr. 3 (1989): Ökumenische Rundschau, Band 38, Heft 3
Analysis of Dimensional Influence of Convolutional Neural Networks for Histopathological Cancer Classification
Creators: name: Labhsetwar, Shreyas Rajesh
name: Baretto, Alistair Michael
name: Salvi, Raj Sunil
name: Kolte, Piyush Arvind
name: Venkatesh, Veerasai Subramaniam
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Convolutional Neural Networks can be designed with different levels of complexity depending upon the task at hand. This paper analyzes the effect of dimensional changes to the CNN architecture on its performance on the task of Histopathological Cancer Classification. The research starts with a baseline 10-layer CNN model with (3 X 3) convolution filters. Thereafter, the baseline architecture is scaled in multiple dimensions including width, depth, resolution and a combination of all of these. Width scaling involves inculcating greater number of neurons per CNN layer, whereas depth scaling involves deepening the hierarchical layered structure. Resolution scaling is performed by increasing the dimensions of the input image, and compound scaling involves a hybrid combination of width, depth and resolution scaling. The results indicate that histopathological cancer scans are very complex in nature and hence require high resolution images fed to a large hierarchy of Convolution, MaxPooling, Dropout and Batch Normalization layers to extract all the intricacies and perform perfect classification. Since compound scaling the baseline model ensures that all the three dimensions: width, depth and resolution are scaled, the best performance is obtained with compound scaling. This research shows that better performance of CNN models is achieved by compound scaling of the baseline model for the task of Histopathological Cancer Classification.
description: conference
Dynamic fluctuations in the superconductivity of NbN films from microwave conductivity measurements
Creators: name: Ohashi, Takeyoshi
name: Kitano, Haruhisa
name: Maeda, Astutaka
name: Akaike, Hiroyuki
name: Fujimaki, Akira
Publisher: name: arXiv
Year: 2006
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We have measured the frequency and temperature dependences of complex ac conductivity, σ(ω)=σ_1(ω)-iσ_2(ω), of NbN films in zero magnetic field between 0.1 to 10 GHz using a microwave broadband technique. In the vicinity of superconducting critical temperature, Tc, both σ_1(ω) and σ_2(ω) showed a rapid increase in the low frequency limit owing to the fluctuation effect of superconductivity. For the films thinner than 300 nm, frequency and temperature dependences of fluctuation conductivity, σ(ω,T), were successfully scaled onto one scaling function, which was consistent with the Aslamazov and Larkin model for two dimensional (2D) cases. For thicker films, σ(ω,T) data could not be scaled, but indicated that the dimensional crossover from three dimensions (3D) to 2D occurred as the temperature approached Tc from above. This provides a good reference of ac fluctuation conductivity for more exotic superconductors of current interest.
description: 8 pages, 7 Figures, 1 Table, Accepted for publication in PRB
Geschlechtliche Vielfalt und Transgeschlechtlichkeit in der Kinder- und Jugendliteratur: Die Graphic Novel Nennt mich Nathan von Catherine Castro & Quentin Zuttion
Creators: name: Meyer, Liane
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: Graphic Novel
subject: Diversität
subject: Transgeschlechtlichkeit
subject: transgender
subject: 430
subject: Graphic Novel
subject: Vielfalt
subject: Transgender
subject: Kinderliteratur
subject: Jugendliteratur

description: DoLiMette;9. Jg. 2021, Heft 1
Assessment of Utilization Potential of Biomass Volatiles and Biochar as a Reducing Agent for Iron Ore Pellets
Creators: name: Das, Dipika
name: Anand, Amrit
name: Gautam, Shalini
name: Rajak, Vinay Kumar
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: India is an agricultural country and near about 500 MT of agricultural wastes are generated each year. India has huge reserves of low-grade iron ore fines. Therefore, considering the availability of these two, the present study mainly focuses on utilization of solid waste in iron and steel industry; also, biomass being carbon-neutral fuel, promotes mitigation of environmental issues. To carry out this study, agricultural wastes like groundnut shell and corn cob which contain more than 70% of volatile matter were considered. Hence, an attempt has been taken to utilize this volatiles as well as char (prepared at 350°C) of corn cob and groundnut shell as a reducing agent for reduction of iron ore pellets. Maximum reduction percentage was achieved at 1000°C and 75 min using corn cob as a reductant, i.e., 78.38% with its volatile and 92.01% using its char. Higher intensity of elemental iron is also reflected by X-ray Diffraction analysis of reduced pellets. Further, cost estimation of reduction of iron ore pellets was also done using both the reducing agents, which signifies that the reduction process using biomass volatiles is much more economical than biochar. The total cost of producing DRI from corn cob volatiles is 56% less than coal followed by groundnut shell volatiles 53.36% and minimum in the case of groundnut shell char 36.17%.
Hamiltonian 2-forms in Kahler geometry, IV Weakly Bochner-flat Kahler manifolds
Creators: name: Apostolov, Vestislav
name: Calderbank, David M. J.
name: Gauduchon, Paul
name: Tonnesen-Friedman, Christina W.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C55; 53C25

description: We study the construction and classification of weakly Bochner-flat (WBF) metrics (i.e., Kahler metrics with coclosed Bochner tensor) on compact complex manifolds. A Kahler metric is WBF if and only if its `normalized' Ricci form is a hamiltonian 2-form: such 2-forms were introduced and studied in previous papers in the series. It follows that WBF Kahler metrics are extremal. We construct many new examples of WBF metrics on projective bundles and obtain a classification of compact WBF Kahler 6-manifolds, extending work by the first three authors on weakly selfdual Kahler 4-manifolds. The constructions are independent of previous papers in the series, but the classification relies on the classification of compact Kahler manifolds with a hamiltonian 2-form in math.DG/0401320 as well as some of the results in math.DG/0511118.
description: 22 pages, 11 figures, sequel to math.DG/0511118, math.DG/0401320 and math.DG/0202280, but partly self-contained
Discovery of potential inhibitors for phosphodiesterase 5A, sodium-potassium pump and beta-adrenergic receptor from Terminalia arjuna: In silico approach
Creators: name: Dinanath T. Gaikwad
name: Namdeo R. Jadhav
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: The aim of this work was to perform in silico analysis of selected biomolecules from Terminalia arjuna (T. arjuna) by using virtual screening, molecular docking and pharmacophore modeling. Reported 30 biomolecules of T. arjuna were used as ligands. Grip-based docking was carried out to produce the target-specific complex model using vLife MDS 4.4 software. Docked conformations of the selected T. arjuna biomolecules resulted in 8 potential biomolecules namely Casuarinin, Luteolin, Pelargonidin, Arjunin, Castalagin, Punicalagin, Kaempferol, and Quercetin with major interactions and exhibited good affinity to the residues of protein targets. Developed pharmacophore models have suggested minimum pharmacophoric features required in the biomolecule so as to show standard like activity. Interestingly, Casuarinin showed multiple inhibitions on phosphodiesterase 5A and sodium-potassium pump whereas Pelargonidin on phosphodiesterase 5A and beta-adrenergic protein targets. Conclusively, this study provides a suitable platform for discovery of novel inhibitors from natural source for heart disorders.
Identification of Hot Spot Residues on Serine-Arginine Protein Kinase-1 by Molecular Dynamics Simulation Studies
Creators: name: Anshuman Chandra
name: Nainee Goyal
name: Imteyaz Qamar
name: Nagendra Singh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Serine-arginine protein kinase1 (SRPK1) is a highly specific kinase that recognizes serine-arginine dipeptide repeats and phosphorylates SR rich splicing factor ASF/SF2 in a cell-cycle regulated manner. SRPK1 processively phosphorylates serine residues on its substrate ASF/SF2. Elevated expression pattern of both SRPK1 and ASF/SF2 and their association with various carcinomas have established SRPK1 as a potent target for drug design against cancers. In order to develop specific inhibitors the binding of ASF/SF2 to SRPK1 is desired to be selectively intruppted. We have performed molecular dynamics simulation studies on crystal structure of SRPK1 complex with ASF/SF2. The ASF/SF2 acquired a stable binding on the surface of SRPK1 with strong attractive forces. Analysis revealed that there was no major position shifting of the core β-sheet region within the catalytic site of SRPK1 when present in the state of ASF/SF2 bound in comparison to apo form. Global motions of SRPK1 indicated that major stable structural changes occurred after the substrate binding. The interactions between SRPK1 and ASF/SF2 were examined and calculated during molecular dynamics simulation of 1µs. Molecular dynamics study indicated Arg84, Lys85, Leu86, Lys174, Tyr227 and Leu479 residues of SRPK1 as essential hot spots involved in the stable binding with substrate. Structural analysis of the binding affinity and hot spot investigation provided significant information on ASF/SF2 binding which may also be considered for designing of the novel specific inhibitors of SRPK1 for the applications in cancer therapy.
Using Natural Language Relations between Answer Choices for Machine Comprehension
Creators: name: Pujari, Rajkumar
name: Goldwasser, Dan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: When evaluating an answer choice for Reading Comprehension task, other answer choices available for the question and the answers of related questions about the same paragraph often provide valuable information. In this paper, we propose a method to leverage the natural language relations between the answer choices, such as entailment and contradiction, to improve the performance of machine comprehension. We use a stand-alone question answering (QA) system to perform QA task and a Natural Language Inference (NLI) system to identify the relations between the choice pairs. Then we perform inference using an Integer Linear Programming (ILP)-based relational framework to re-evaluate the decisions made by the standalone QA system in light of the relations identified by the NLI system. We also propose a multitask learning model that learns both the tasks jointly.
description: Published at NAACL-HLT 2019. This version has link to code repository. 6 pages, 3 figures & 2 tables
A method of light reflectance measurement
Creators: name: Ke, Lun
Publisher: name: University of British Columbia
Year: 2009

description: The quality of light reflectance models in realistic image synthesis is directly related to the quality of computer generated images. In order to develop such models, actual light reflectance distribution data are required. One way to express the reflectance properties of a surface is called bidirectional reflectance distribution function, or BRDF. BRDF is a function with four degrees of freedom, two for the direction of incident light and two for the direction of reflected light. It requires acquiring large amount of data through measurements and the process is very time consuming. In this thesis, an automated measurement method is presented and implemented. A 3- channel CCD camera is calibrated and used as the light measuring device. The system used is called ACME (ACtive Measurement Facilities). Within ACME, all devices in the system are under robotics control. Experiments are written in Java, and can be loaded from any machine via Internet and run on the local server. Several material samples are measured by using this system including paper and silk, and reliable data were obtained. The overall error is estimated to be less than 8 % . It can be concluded that a CCD camera can be used to measure light reflectance properties for computer graphics, and it is relatively fast and convenient.
An Effective Operators Analysis of Leptonic CP Violation : Bridging High and Low Energy Processes
Creators: name: Chang, We-Fu
name: Ng, John N.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the leptonic CP violation by employing the complete set of dimension-six pure leptonic effective operators. Connection among the observable at different energy scales can be made by the running of the renormalization group equations. Explicitly, we study the charged lepton electric dipole moment, muon Michel decay, and the triple spin-momentum correlations at the Linear Collider. We found the electron electric dipole moment, which starts at 2-loop level, severely constrains the possibilities to detect the CP violating signatures in muon decay and at the linear colliders.
description: 16 pages, 9 figures, discussion on dipole operator and reference added
Prévenir et maîtriser le risque infectieux dans les résidences autonomie et les foyers hébergeant des adultes handicapés Retour d’expérience sur le plan d’accompagnement expérimental 2021-2022 en Bourgogne-Franche-Comté
Creators: name: Floret, Nathalie
name: Mainy, Nadia
name: Vandenhoecq, Hélène
name: Berjamy, Fatima
name: Tiv, Michel
name: Balluet, Patricia
name: Fèvre, Marlène
name: Hamelin, Isabelle
name: Poignet, Sylvie
name: Barthod, Valérie
name: Pacot, Jérôme
name: Sehier, Emmanuel
name: Rousseaux, Isabelle
Publisher: name: Health & Co
Year: 2024
Subjects: Prévention
Risque infectieux
Appui
Maîtrise
Retex
Résidences autonomie

description: À partir des enseignements tirés de la pandémie à SARS-CoV2, l’agence régionale de santé Bourgogne-Franche-Comté a mobilisé le centre d’appui pour la prévention des infections associées aux soins (CPias) et le Réseau qualité en santé (RéQua) pour proposer un plan d’accompagnement spécifique et complémentaire aux établissements peu ou pas médicalisés (résidences autonomie et foyers hébergeant des adultes handicapés) de la région. L’objectif général était d’accompagner les directeurs de ces établissements pour dynamiser leur démarche qualité et de gestion des risques (volet RéQua) et initier ou consolider les organisations pour prévenir et maîtriser le risque infectieux (volet CPias). Pour ce faire, des moyens humains et organisationnels ont été proposés. Le plan s’est déroulé entre le 1er septembre 2021 et le 31 décembre 2022. L’article présente l’organisation et le retour de cette expérience originale en région.
Performance Analysis of Optimizers for Plant Disease Classification with Convolutional Neural Networks
Creators: name: Labhsetwar, Shreyas Rajesh
name: Haridas, Soumya
name: Panmand, Riyali
name: Deshpande, Rutuja
name: Kolte, Piyush Arvind
name: Pati, Sandhya
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Crop failure owing to pests & diseases are inherent within Indian agriculture, leading to annual losses of 15 to 25% of productivity, resulting in a huge economic loss. This research analyzes the performance of various optimizers for predictive analysis of plant diseases with deep learning approach. The research uses Convolutional Neural Networks for classification of farm or plant leaf samples of 3 crops into 15 classes. The various optimizers used in this research include RMSprop, Adam and AMSgrad. Optimizers Performance is visualised by plotting the Training and Validation Accuracy and Loss curves, ROC curves and Confusion Matrix. The best performance is achieved using Adam optimizer, with the maximum validation accuracy being 98%. This paper focuses on the research analysis proving that plant diseases can be predicted and pre-empted using deep learning methodology with the help of satellite, drone based or mobile based images that result in reducing crop failure and agricultural losses.
description: conference
Understanding the mechanism of Amygdalin's multifunctional anti-cancer action using computational approach
Creators: name: Khattab Al-Khafaji
name: Tugba Taskin Tok
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Amygdalin possesses anticancer properties and induces apoptosis. Based on experimental studies the presence of amygdalin with cancer cells led to activate the caspase-3 and BAX and inhibits Bcl-2 and Poly (ADP-ribose) polymerase-1 (PARP-1) but without deep information on action mode of these activities. Herein, we leaped forward to examine the molecular dynamics of the bound amygdalin and free ligand proteins, to identify precise action (conformation changes in targeted proteins) of amygdalin through using double docking and molecular dynamics (MD) simulations for 50 ns time scale. The MD simulations revealed that the binding of amygdalin led to disrupting the interaction between the Bcl-2/BAX complex. We furthermore conducted MD simulation for Bcl-2/amygdalin to investigate the stability of the complex which is responsible for inhibition of Bcl-2. It has been obtained a stable Bcl-2/amygdalin complex during the 50 ns. The results give a detail explanation of how amygdalin activates BAX and inhibits Bcl-2. For caspase-3, the matter is different, we found that amygdalin led to disrupting the interaction of caspase-3's two chains for intervals during 50 ns and then bind together repeatedly. The mechanism of caspase-3's activation through switching by disrupt the interacts for periodic intervals manner. For PARP-1, the dynamics simulations results indicated amygdalin interacts with PARP-1’s binding site and forms stable interaction during simulation to render it inactive. Hence, amygdalin revealed a supernatural behavior through the MD simulations: it revealed a further clarification of the mystery amygdalin's experimental action which can act as a multifunctional drug in the cancer therapeutics.
Meta-analysis of the cultural context
Creators: name: Balzani, Roberto
name: Musiani, Elena
Publisher: name: Zenodo
Year: 2023
Subjects: Project CHANGES
PNRR
Partenariato Esteso 5
Project deliverable
Work Package 2

description: In this deliverable, we present the approach we have developed for analysing the literature of the last few years (2019-2023), aiming at answering two specific research questions, i.e. (1) How have digital applications enriched museum narratives and which areas have they influenced in the last 5 years? (2) How has public fruition been enhanced in the process? We identified 245 relevant bibliographic resources, and the results of a preliminary empirical analysis conducted on them resulted in the identification of three large macro-areas of discussion – i.e. narratives, new museums, and objects. Further results, obtained by applying the PRISMA method for Meta-Analysis of bibliographic literature will be presented in the next deliverable of the Work Package 2, i.e. D7 - Guidelines and best practices for technology-aided narratives for museums and art collections.
3D/4D ultrasound registration of bone
Creators: name: Schers, Jonathan
name: Troccaz, Jocelyne
name: Daanen, Vincent
name: Fouard, Céline
name: Plaskos, Christopher
name: Kilian, Pascal
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Computer Science (cs.OH)
subject: Medical Physics (physics.med-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: This paper presents a method to reduce the invasiveness of Computer Assisted Orthopaedic Surgery (CAOS) using ultrasound. In this goal, we need to develop a method for 3D/4D ultrasound registration. The premilinary results of this study suggest that the development of a robust and ``realtime'' 3D/4D ultrasound registration is feasible.
The Colours of Elliptical galaxies
Creators: name: Chang, Ruixiang
name: Gallazzi, Anna
name: Kauffmann, Guinevere
name: Charlot, Stéphane
name: Ivezić, Željko
name: Brinchmann, Jarle
name: Heckman, Timothy M.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have compiled a sample of 2728 nearby ($z<0.08$) elliptical galaxies with photometry in the $g,r,i,z$ bands from the Sloan Digital Sky Survey (SDSS) and $J,H,K$ photometry from the Two Micron All Sky Survey (2MASS). Stellar masses, stellar velocity dispersions and structural parameters such as sizes and surface mass densities are also available for these objects. In order to correct the aperture mismatch between SDSS and 2MASS, we correct the SDSS magnitudes to the isophotal circular radius where the 2MASS magnitudes are measured. We compare the correlations between optical, optical-infrared and infrared colours and galaxy luminosity, stellar mass, velocity dispersion and surface mass density. We find that all galaxy colours correlate more strongly with stellar mass and velocity dispersion than with any other structural parameter. The dispersion about these two relations is also smaller. We also study the correlations between a variety of stellar absorption line indices and the same set of galaxy parameters and we reach very similar conclusions. Finally, we analyze correlations between absorption line indices and colour. Our results suggest that the optical colours of elliptical galaxies are sensitive to a combination of age, metallicity and $α$-enhancement, while the optical-infrared colours are sensitive to metallicity and to $α$-enhancement, but are somewhat less sensitive to age.
description: 13 pages, 8 figures, accepted by MNRAS
Precision test of statistical dynamics with state-to-state ultracold chemistry
Creators: name: Liu, Yu
name: Hu, Ming-Guang
name: Nichols, Matthew A.
name: Yang, Dongzheng
name: Xie, Daiqian
name: Guo, Hua
name: Ni, Kang-Kuen
Publisher: name: arXiv
Year: 2020
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Chemical reactions represent a class of quantum problems that challenge both the current theoretical understanding and computational capabilities. Reactions that occur at ultralow temperatures provide an ideal testing ground for quantum chemistry and scattering theories, as they can be experimentally studied with unprecedented control, yet display dynamics that are highly complex. Here, we report the full product state distribution for the reaction 2KRb $\rightarrow$ K$_2$ + Rb$_2$. Ultracold preparation of the reactants grants complete control over their initial quantum degrees of freedom, while state-resolved, coincident detection of both products enables the measurement of scattering probabilities into all 57 allowed rotational state-pairs. Our results show an overall agreement with a state-counting model based on statistical theory, but also reveal several deviating state-pairs. In particular, we observe a strong suppression of population in the state-pair closest to the exoergicity limit, which we precisely determine to be $9.7711^{+0.0007}_{-0.0005}$ cm$^{-1}$, as a result of the long-range potential inhibiting the escape of products. The completeness of our measurements provides a valuable benchmark for quantum dynamics calculations beyond the current state-of-the-art.
description: 31 pages, 6 figures
Homology modeling, structural insights and in-silico screening for selective inhibitors of Mycobacterial CysE
Creators: name: Gupta, Sunita
name: Gupta, Vibha
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Tuberculosis posses a major threat for health practitioners due to lengthy treatment regimen, increase in the drug-resistant strains of Mycobacterium tuberculosis (M. tb) and unavailability of drugs for its persistent form. Therefore, there is an urgent need for discovery of new and improved anti-tubercular drugs. In M. tb, the two step de novo biosynthesis of L-cysteine, an essential metabolic pathway is reported to be up-regulated in the persistent phase of the organism, involves two enzymes CysE and CysK. Although, structural insights for rational drug discovery are available for the later, not much information is known for the former. This study proposes a 3-dimensional model of M. tb CysE followed by in-silico screening of 67,030 anti-tuberculosis bioactive compounds. Subsequently, post-processing of 1000 best hits was carried out and top 200 compounds thus obtained were docked into the active site cleft of E. coli homologue as a control, but revealed unexpected results. Differences in the active site architectures and comparative analysis of molecular electrostatic potentials between the two CysEs provide molecular basis for the compounds C1, C3, C4 and C7 exhibiting preferential binding for M. tb CysE. In addition, shorter N-terminus along with positive and irregular trimeric base of M. tb CysE indicates its biological assembly as trimer. Based on mapping of residues involved in cysteine sensitivity on to the model structure of M. tb CysE, it is hypothesized that feedback inhibition of this homologue by cysteine may be affected.
Thin Domain Walls in Lyra Geometry
Creators: name: Rahaman, F.
name: Kalam, M.
name: Mondal, R.
Publisher: name: arXiv
Year: 2006
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: This paper studies thin domain walls within the frame work of Lyra Geometry. We have considered two models. First one is the thin domain wall with negligible pressures perpendicular and transverse direction to the wall and secondly, we take a particular type of thin domain wall where the pressure in the perpendicular direction is negligible but transverse pressures are existed. It is shown that the thin domain walls have no particle horizon and the gravitational force due to them is attractive.
description: 8 pages, typos are corrected, published Astrophysics and Space Sciences 305, 337 (2006)
title: Traffic Accident Rates in Kentucky
title: (1984)
titleType: Subtitle
Creators: name: Agent, Kenneth R.
Publisher: name: Kentucky Transportation Center, University of Kentucky
Year: 1986
Subjects: subject: Transportation Engineering

description: Average accident rates, using 1984 accident data only as well as combined 1980 through 1984 data, were calculated for Kentucky highways. Comparison of 1984 to combined 1980 through 1983 rates show the rates have remained stable. There was an increase in total accidents and total accident rate in 1984 compared to 1980 through 1983 data while there was a decrease in the fatal accident rate. Several methods of classifying highways were used when calculating average rates. Those rates may be used in the high-accident location identification program. Average and critical numbers of accidents also were determined for use in the high-accident location program.
Engineering Decentralized Markets – A Blockchain Approach
Creators: name: Notheisen, Benedikt
Publisher: name: Karlsruhe
Year: 2019

description: In der Dissertation wird die Eignung der Distributed Ledger oder Blockchain-Technologie als Infrastruktur für dezentrale Marktplattformen untersucht. Dies beinhaltet die Schaffung eines konzeptionellen Rahmens, die technische Umsetzung durch Prototypen und die Analyse ökonomischer Auswirkungen. Im ersten Schritt kombiniert die vorliegende Arbeit die Ergebnisse einer strukturierten Literaturrecherche mit dem Market Engineering-Ansatz von Weinhardt und Gimpel (2007). Das resultierende „Blockchain Engineering Framework“ beschreibt den Aufbau und die Kernelemente blockchainbasierter Marktplattformen, zeigt Grenzen der Technologie auf und bietet einen Rahmen zur Strukturierung und Kommunikation von Forschungsvorhaben und -ergebnissen. Aus technologischer Sicht veranschaulichen zwei Prototypen die Implementierung und den Betrieb dezentraler Märkte. Der erste Prototyp betrachtet die Anwendung in Märkten mit Qualitätsunterschieden und Informationsasymmetrien anhand des Gebrauchtwagenmarktes. Der zweite Prototyp konzentriert sich auf Mikrostrukturaspekte und stellt einen Ansatz zum Handel von Aktien vor. Durch die Prototypen wird deutlich, wie die verteilte Datenbank Transparenz schafft und wie die diskrete Funktionsweise des Konsensmechanismus Interaktionen beeinflusst. Der dritte Teil greift diese Erkenntnisse auf und untersucht ökonomische Auswirkungen. In einem zweiperiodigen Spiel mit unvollständiger Information wird gezeigt, dass die öffentliche Verfügbarkeit von Qualitätsinformation zu opportunistischem Verhalten einzelner Marktteilnehmer und Marktversagen führen kann. Um den Einfluss der Kapazität und Frequenz neuer Datenblöcke auf die Qualität dezentraler Märkte zu analysieren, werden die entsprechenden Marktergebnisse mit Hilfe von Orderdaten der Börse Stuttgart nachgebildet. Die Auswertung der resultierenden Datengrundlage legt nahe, dass größere und schnellere Blöcke die Aktivität und Liquidität steigern. Gleichzeitig begrenzt eine Zunahme von Preisschwankungen die Skalierbarkeit dezentraler Märkte. Insgesamt stellt diese Dissertation einen ersten Schritt in der Analyse und Gestaltung dezentraler Marktplattformen dar. Sie skizziert wesentliche Elemente, demonstriert die technische Machbarkeit, beleuchtet ökonomische Konsequenzen und hebt zukünftigen Forschungsbedarf hervor.
Winter by the Sea
Creators: name: Ochurte, Rufino
name: Mixco, Mauricio J.
Publisher: name: California Language Archive, University of California, Berkeley
Year: 2021
Subjects: subject: klb

description: See Kiliwa Texts: "When I have Donned My Crest of Stars" (University of Utah Press, 1983), p. 186 for transcription, segmentation, glossing, and translation of this story.
1986 Safety Belt and Child Safety Seat Usage Rates in Kentucky
Creators: name: Agent, Kenneth R.
Publisher: name: Kentucky Transportation Center, University of Kentucky
Year: 1986
Subjects: subject: Transportation Engineering

description: The objective of the survey summarized in this report is to establish 1986 safety belt and child safety seat usage rates in Kentucky to compare to those determined from previous surveys. Also included in this report is an analysis of accident records evaluating the effectiveness of safety belts.  Statewide usage rages in the 19 cities previously surveyed in 1982, 1983, 1984, and 1985 showed that driver safety belt usage increased in 1986 while child safety seat and safety belt usage remained at the 1984 and 1985 levels. The statewide usage rate of safety belts by drivers was 13.0 percent in 1986 compared to 9.2 percent in 1985, 6.9 percent in 1984, 5.8 percent in 1983, and 4.2 percent in 1982. The percentage of children in either a safety seat or belt was 30.2 percent in 1986 compared to 29.1 percent in 1985, 30.3 percent in 1984, 24.2 percent in 1983, and 15.4 percent in 1982. Usage rates for front-seat passengers in 1986 were higher than those determined in 1985 for each age category.  Benefits in the reduction of injuries for occupants wearing a safety belt or in a safety seat were shown through the analysis of accident records. For example, a 41 percent reduction in fatal or incapacitating injuries was determined for drivers wearing a safety belt compared to those who were not restrained.
New galactic open cluster candidates from DSS and 2MASS imagery
Creators: name: Kronberger, M.
name: Teutsch, P.
name: Alessi, B.
name: Steine, M.
name: Ferrero, L.
name: Graczewski, K.
name: Juchert, M.
name: Patchick, D.
name: Riddle, D.
name: Saloranta, J.
name: Schoenball, M.
name: Watson, C.
Publisher: name: arXiv
Year: 2005
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: An inspection of the DSS and 2MASS images of selected Milky Way regions has led to the discovery of 66 stellar groupings whose morphologies, color-magnitude diagrams, and stellar density distributions suggest that these objects are possible open clusters that do not yet appear to be listed in any catalogue. For 24 of these groupings, which we consider to be the most likely to be candidates, we provide extensive descriptions on the basis of 2MASS photometry and their visual impression on DSS and 2MASS. Of these cluster candidates, 9 have fundamental parameters determined by fitting the color-magnitude diagrams with solar metallicity Padova isochrones. An additional 10 cluster candidates have distance moduli and reddenings derived from K magnitudes and (J-K) color indices of helium-burning red clump stars. As an addendum, we also provide a list of a number of apparently unknown galactic and extragalactic objects that were also discovered during the survey.
description: 32 pages, 11 figures. Accepted for publication in A&A
Johnius plagiostoma
Creators: name: Hanafi, Norhafiz
name: Chen, Meng-Hsien
name: Chang, Chih-Wei
name: Chao, Ning Labbish
name: Seah, Ying Giat
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Sciaenidae
Johnius
Johnius plagiostoma

description: Johnius plagiostoma (Bleeker, 1849)
(Common name: Big-eye croaker)
(Fig. 12, Table 7)
Corvina plagiostoma Bleeker, 1849: 10 (type locality: Madura Straits near Surabaya and Kammal, Java, Indonesia.) Syntypes: RMNH 5984 (2)
Johnius plagiostoma (Bleeker, 1850): Sasaki, 1999: 276; Sasaki, 2000: 621; Sasaki, 2001: 3157; Mohamad Faisal, 2009: 98; Atan et al., 2010: 195
Material examined. Non-types: NMMB-P37100 (3, 90.97 to 95.43 mm SL), Sarikei, Sarawak, Malaysia, 14 March 2017; NMMB-P37101 (10, 80.93 to 103.56 mm SL), Goebilt, Sarawak, Malaysia, 17 March 2017; NMMB-P31389 (2, 87.72 to 103.64 mm SL), Muar, Johor, Malaysia, 19 March 2019: NMMB-P21525 (3, 81.16 to 94.65 mm SL), Tanjung Piandang, Perak, Malaysia, 6 June 2014; NMMB-P26489 (3, 91.15 to 110.23 mm SL), Kuala Kurau, Perak, Malaysia, 1 June 2014; NMMB-P26500 (3, 87.39 to 105.49 mm SL), Kuala Kurau, Perak, Malaysia, 23 November 2019.
Diagnosis. A species of Johnius with the following combination of characters: snout rounded, never pointed; mouth large, strongly oblique; large eye, 22 to 32% of head length; gill rakers long, slender, equal or slightly shorter than length of gill filaments at angle of arch, 15 on lower limb of first gill arch; second anal spine length long, stiff, about 24 to 40% of HL; and scales moderately small, 8 scale rows above lateral line.
Distribution. Eastern Indian Ocean, western Pacific: Bangladesh and Myanmar east to Java, Borneo and Vietnam.
Remarks. Johnius plagiostoma can be easily differentiated from the rest of other Johnius species in the East Malaysian waters by the oblique mouth and obviously large eye. Johnius plagiostoma is abundant and was available collected only from Sarawak states, specifically in Goebilt and Sarikei collection sites, which mainly segregated in the large mouth and delta riverine system. This might be due to the ecological factor of freshwater and marine waters mainly mixed up, suitable for the species habitat and availability of food resources.
description: Published as part of Hanafi, Norhafiz, Chen, Meng-Hsien, Chang, Chih-Wei, Chao, Ning Labbish & Seah, Ying Giat, 2024, Taxonomic review of the genus Johnius (Perciformes: Sciaenidae) from East Malaysian waters, with comments on newly recorded Johnius species, pp. 85-117 in Zootaxa 5550 (1) on page 106, DOI: 10.11646/zootaxa.5550.1.11, http://zenodo.org/record/14388193
Deep correction of breathing-related artifacts in real-time MR-thermometry
Creators: name: de Senneville, Baudouin Denis
name: Coupé, Pierrick
name: Ries, Mario
name: Facq, Laurent
name: Moonen, Chrit
Publisher: name: arXiv
Year: 2020
Subjects: subject: Medical Physics (physics.med-ph)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Real-time MR-imaging has been clinically adapted for monitoring thermal therapies since it can provide on-the-fly temperature maps simultaneously with anatomical information. However, proton resonance frequency based thermometry of moving targets remains challenging since temperature artifacts are induced by the respiratory as well as physiological motion. If left uncorrected, these artifacts lead to severe errors in temperature estimates and impair therapy guidance. In this study, we evaluated deep learning for on-line correction of motion related errors in abdominal MR-thermometry. For this, a convolutional neural network (CNN) was designed to learn the apparent temperature perturbation from images acquired during a preparative learning stage prior to hyperthermia. The input of the designed CNN is the most recent magnitude image and no surrogate of motion is needed. During the subsequent hyperthermia procedure, the recent magnitude image is used as an input for the CNN-model in order to generate an on-line correction for the current temperature map. The method's artifact suppression performance was evaluated on 12 free breathing volunteers and was found robust and artifact-free in all examined cases. Furthermore, thermometric precision and accuracy was assessed for in vivo ablation using high intensity focused ultrasound. All calculations involved at the different stages of the proposed workflow were designed to be compatible with the clinical time constraints of a therapeutic procedure.
description: 21 pages, 9 figures, 1 table
A study of bandwidth allocation mechanisms on sonet-ring-based transport networks
Creators: name: Zhang, Dingliang
Publisher: name: University of British Columbia
Year: 2009

description: A new SONET-based network simulator was designed and implemented to study the performance of different routing mechanisms on transport networks based on the SONET ring architecture. The simulator incorporates some unique features of the SONET technology. Three static routing schemes were evaluated on the simulator at different levels of traffic load. The hop-by-hop routing (HHR) scheme uses the physical network as a fat bit pipe to transport the data traffic from one node to its neighboring node. Utilizing the Digital Cross-connect System in the SONET technology, virtual topology routing (VTR) schemes establish the multiple-hop point-to-point links across a SONET ring in order to reduce overall nodal processing time. The simulation results show that virtual topology routing schemes have advantage of low network latency over the hop-by-hop routing scheme only when the bursty traffic load is well below the network capacity. In medium to high traffic load conditions, increased queuing delay counteracts the reduced overall nodal processing time in the VTR schemes, resulting in high network latency, while the HHR scheme have the advantage of high bandwidth utilization and low packet-drop rates. To overcome the drawbacks of the static routing schemes, dynamic bandwidth-allocation mechanisms combining VTR and HHR principles were suggested. The mechanisms allocate bandwidth dynamically between VTR and HHR regions in response to the changes in traffic patterns on a SONET ring. Both centralized model and distributed model were proposed. For the centralized model, the problem of optimal effective bandwidth allocation on the Unidirectional Path Switched Ring (UPSR) architecture was formulated and a solution based on a Greedy algorithm with cost of 0(n²m + mlogm) was provided for UPSR architecture with n nodes and m flows. A heuristic bandwidth optimization algorithm based on the solution for UPSR was developed and evaluated numerically for Bidirectional Path Switched Ring (BPSR) architecture. The possibilities of extending the heuristic algorithms to other SONET-ring-based architectures were also explored. For the distributed model, a mechanism was proposed to maintain the tension between bandwidth utilization and network latency in local scope rather than in global scope. By resolving problem early and locally, intensive computation of global bandwidth optimization and synchronization of global reconfiguration may be avoided.
Firimg PbO - free glass enamels using the CW - CO₂ laser
Creators: name: Hahn, Karlheinz
name: Buerhop, Claudia
name: Weißmann, Rudolf
Publisher: name: Offenbach : Verlag der Deutschen Glastechnischen Gesellschaft
Year: 1996
Subjects: subject: 660

description: The firing of glass enamels, which are applied to decorate glass products, is usually done in a furnace. Α new and suitable technique for firing glass enamels is to make use of the high-power CW-CO₂ laser. Its be am (wavelength 10.6 μm) induces a very fast heating of the enamelled glass within a small surface layer. This makes it possible to fire glass enamels at temperatures above 1000°C, without any deformation of the Substrate glass body In this temperature ränge an amount of the harmful component PbO in t he glass enamel is n o longer necessary The PbO-free glass flux of the enamel is made easily by milhng the Substrate glass (float glass). The gloss and smoothness of the laser-fired enamel are comparable to the conventionally fired enamel. The absence of PbO and the high firing temperatures are very advantageous to the chemical resistance of the enamels, meaning excellent dishwasher durability.
Altered inhibition and excitation in neocortical circuits in congenital microcephaly
Creators: name: Zaqout, Sami
name: Blaesius, Kathrin
name: Wu, Yuan-Ju
name: Ott, Stefanie
name: Kraemer, Nadine
name: Becker, Lena-Luise
name: Rosário, Marta
name: Rosenmund, Christian
name: Strauss, Ulf
name: Kaindl, Angela M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Cdk5rap2
subject: Dendritic morphogenesis
subject: Microcephaly
subject: Neuronal differentiation
subject: Synaptic transmission
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Congenital microcephaly is highly associated with intellectual disability. Features of autosomal recessive primary microcephaly subtype 3 (MCPH3) also include hyperactivity and seizures. The disease is caused by biallelic mutations in the Cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2. In the mouse, Cdk5rap2 mutations similar to the human condition result in reduced brain size and a strikingly thin neocortex already at early stages of neurogenesis that persists through adulthood. The microcephaly phenotype in MCPH arises from a neural stem cell proliferation defect. Here, we report a novel role for Cdk5rap2 in the regulation of dendritic development and synaptogenesis of neocortical layer 2/3 pyramidal neurons. Cdk5rap2-deficient murine neurons show poorly branched dendritic arbors and an increased density of immature thin spines and glutamatergic synapses in vivo. Moreover, the excitatory drive is enhanced in ex vivo brain slice preparations of Cdk5rap2 mutant mice. Concurrently, we show that pyramidal neurons receive fewer inhibitory inputs. Together, these findings point towards a shift in the excitation - inhibition balance towards excitation in Cdk5rap2 mutant mice. Thus, MCPH3 is associated not only with a neural progenitor proliferation defect but also with altered function of postmitotic neurons and hence with altered connectivity.