cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
64Cu-ATSM and 99mTc(CO)3-DCM20 potential in the early detection of rheumatoid arthritis
Creators: name: Dam, Trang Thuy
name: Hanaoka, Hirofumi
name: Nakajima, Takahito
name: Yamaguchi, Aiko
name: Okamura, Koichi
name: Chikuda, Hirotaka
name: Tsushima, Yoshito
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Molecular imaging constitutes a promising technique for the early detection of rheumatoid arthritis (RA). Macrophages and hypoxia play significant roles in inflamed synovium. In the present study, we evaluated the efficacy of radiopharmaceuticals that target macrophage mannose receptors (99mTc-labeled mannosylated dextran or 99mTc(CO)3-DCM20) and hypoxia (copper(II) diacetyl-di(N4-methylthiosemicarbazone) or Cu-ATSM) for the early detection of RA in collagen-induced arthritis (CIA) mice models. CIA model was developed in DBA/1 mice, and the clinical score for arthritis was visually assessed on a regular basis. Two biodistribution studies were performed in a paired-labeled format using 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG) as a reference: (1) 99mTc(CO)3-DCM20 with 18F-FDG and (2) 67Cu-ATSM with 18F-FDG. The accumulation levels of 99mTc(CO)3-DCM20 and 67Cu-ATSM in forepaws, hindpaws, and knee joints of CIA mice were significantly higher than that of control mice. In contrast, 18F-FDG uptake in hindpaws and knee joints showed no significant difference between CIA and control mice. The radioactivity levels of 99mTc(CO)3-DCM20 and 67Cu-ATSM were significantly correlated with the clinical scores for the paws. These results suggest the potential usefulness of 99mTc(CO)3-DCM20 and radiolabeled Cu-ATSM for the imaging and early detection of RA.
Ophthalmological abnormalities in Dubowitz Syndrome
Creators: name: Soares, Andreia
name: Ribeiro, Sara
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Introduction: Dubowitz syndrome is a rare autosomal recessive disorder characterized by several congenital abnormalities, which include a wide range of both external and intraocular ophthalmologic deformities. We present a case report of a patient with Dubowitz Syndrome. Case report: A 3-year-old boy with Dubowitz syndrome was referred for ophthalmology consultation. The external ophthalmological examination showed bilateral blepharophimosis/ptosis, telecanthus and epicanthic folds. Cycloplegic retinoscopy revealed high hyperopia (+ 8.00 diopters) and the patient had convergent strabismus. Biomicroscopy and fundus examination were normal. Discussion/Conclusion: Dubowitz syndrome should be considered in the differential diagnosis of syndromes that present with the described external ophthalmological malformations. The ophthalmologist has to refer these patients to a specialized group able to integrate these anomalies with other systemic deformities, allowing a correct diagnosis and proper treatment.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
Shearing or Compressing a Soft Glass in 2D: Time-concentration superposition
Creators: name: Cicuta, Pietro
name: Stancik, Edward J.
name: Fuller, Gerald G.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We report surface shear rheological measurements on dense insoluble monolayers of micron sized colloidal spheres at the oil/water interface and of the protein $β$-lactoglobulin at the air/water surface. As expected, the elastic modulus shows a changing character in the response, from a viscous liquid towards an elastic solid as the concentration is increased, and a change from elastic to viscous as the shear frequency is increased. Surprisingly, above a critical packing fraction, the complex elastic modulus curves measured at different concentrations can be superposed to form a master curve, by rescaling the frequency and the magnitude of the modulus. This provides a powerful tool for the extrapolation of the material response function outside the experimentally accessible frequency range. The results are discussed in relation to recent experiments on bulk systems, and indicate that these two dimensional monolayers should be regarded as being close to a soft glass state.
description: to appear in PRL
Proposal of the Creation of Resources for the Maintenance of the Production Capability of the Agricultural Land Fund by Way of Tax Savings
Creators: name: Gebeltova, Zdenka
name: Pletichova, D.
name: Gebeltova, Zdenka
name: Pletichova, D.
Publisher: name: Unknown
Year: 2012
Subjects: subject: Community/Rural/Urban Development
subject: Crop Production/Industries
subject: Farm Management
subject: Land Economics/Use
subject: Livestock Production/Industries
subject: Production Economics
subject: Agricultural land fund
subject: production capability
subject: estimated pedologic-ecological unit
subject: tax savings
subject: item deductible from the tax base
subject: official and market price of agricultural land
subject: costs.

description: The article contains a proposal of the methodology for the creation of resources, monetary funds into agriculture by way of tax savings. Those are created by way of the utilization of items deductible from the tax base. The average official price of agricultural land for the cadastral area and a proposed “land rate” (3.3%) were used for the calculation of deductible items. The land rate was calculated as the inverse value of the return time for investments in agricultural land. The calculated tax savings according to the relevant tax rate and the amount of the deductible item constitutes the amount of CZK 306 - 388/ha of agricultural land depending on the type of business entity. The arisen savings correspond, for example, to the compensation for the cancelled TOP-UP (2010) payments for agricultural land. Other reserves within the current economic system (untaxed agricultural subsidies) could also lead, for example, to the protection of the agricultural land fund in terms of quantity and quality. The said results can be important not only from an information standpoint, but primarily from a methodological standpoint. The article was drawn up as part of VZ MSM 6046070906 “Economy of Resources of Czech Agriculture and Their Effective Utilization within Multifunctional Agricultural-Food Systems”.
Additional file 6 of Diverse coping modes of maize in cool environment at early growth
Creators: name: Sowiński, Paweł
name: Wieliczko-Manowska, Katarzyna
name: Grzybowski, Marcin
name: Jończyk, Maciej
name: Sowiński, Jakub
name: Sobkowiak, Alicja
name: Kowalec, Piotr
name: Rogacki, Janusz
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 6. List of inbred lines used in Experiment I.
InSAR Phase Denoising: A Review of Current Technologies and Future Directions
Creators: name: Xu, Gang
name: Gao, Yandong
name: Li, Jinwei
name: Xing, Mengdao
Publisher: name: arXiv
Year: 2020
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Nowadays, interferometric synthetic aperture radar (InSAR) has been a powerful tool in remote sensing by enhancing the information acquisition. During the InSAR processing, phase denoising of interferogram is a mandatory step for topography mapping and deformation monitoring. Over the last three decades, a large number of effective algorithms have been developed to do efforts on this topic. In this paper, we give a comprehensive overview of InSAR phase denoising methods, classifying the established and emerging algorithms into four main categories. The first two parts refer to the categories of traditional local filters and transformed-domain filters, respectively. The third part focuses on the category of nonlocal (NL) filters, considering their outstanding performances. Latter, some advanced methods based on new concept of signal processing are also introduced to show their potentials in this field. Moreover, several popular phase denoising methods are illustrated and compared by performing the numerical experiments using both simulated and measured data. The purpose of this paper is intended to provide necessary guideline and inspiration to related researchers by promoting the architecture development of InSAR signal processing.
description: G. Xu, Y. Gao, J. Li and M. Xing, "InSAR Phase Denoising: A Review of Current Technologies and Future Directions," IEEE Geoscience and Remote Sensing Magazine, vol. 8, no. 2, pp. 64-82, June 2020. DOI 10.1109/MGRS.2019.2955120
Contributing factors of clinical outcomes at 1 year post-diagnosis in early rheumatoid arthritis patients with tightly controlled disease activity in clinical practice: a retrospective study
Creators: name: Shin-Ya Kawashiri
name: Yushiro Endo
name: Okamoto, Momoko
name: Tsuji, Sosuke
name: Shimizu, Toshimasa
name: Sumiyoshi, Remi
name: Koga, Tomohiro
name: Iwamoto, Naoki
name: Ichinose, Kunihiro
name: Tamai, Mami
name: Nakamura, Hideki
name: Origuchi, Tomoki
name: Kawakami, Atsushi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Computational Biology

description: To determine whether specific parameters contribute to clinical outcomes at 1 year post-diagnosis in early rheumatoid arthritis (RA) patients under the ‘treat-to-target’ strategy in clinical practice. We retrospectively analyzed 125 RA patients selected according to the following criteria; the patients’ symptom duration was ≤6 months, and none had experience with DMARDs. We evaluated the patients’ clinical disease activity at baseline and 1 year of treatment and the musculoskeletal ultrasound (MSUS)-detected synovitis activity at baseline. We performed an analysis to identify parameters that contribute to SDAI remission and the use of biologic/targeted synthetic (b/ts) DMARDs at 1 year post-diagnosis. Forty-seven patients received b/tsDMARDs therapy, and 58 patients achieved SDAI remission at 1 year post-diagnosis. Rheumatoid factor positivity, low patient’s/evaluator’s global assessment at baseline, and methotrexate use at 1 year post-diagnosis were associated with SDAI remission. The baseline clinical disease activity and MSUS scores were not associated with SDAI remission. Anti-cyclic citrullinated peptide antibody positivity/high titer and high swollen joint counts or the presence of severe synovial hypertrophy at baseline were associated with the use of b/tsDMARDs therapy. The value of the expected poor-prognosis factors may be diminished by intensive therapy within the ‘windows of opportunity’.
An Analysis of Research Publications of Central University of Gujarat: A Scientometric Review
Creators: name: Jangra, Rohit
name: Kumbar, Rashmi
name: Kotrayya Agadi
Publisher: name: figshare
Year: 2020
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: The main objective of this study is to find the authorship patterns and degree of collaboration of Central University of Gujarat with a total number of 301 publications during the period 2010 to 2017 derived from Scopus database. The research method of this study was scientometric analysis method. The main research area of Central University of Gujarat was Chemistry. The most preferred journal for publication was Journal of Molecular Liquids and the most prolific author was Prof. Man Singh. The present study revealed several numbers of scientometric indicators like citation pattern, collaborative institutions, most prolific authors etc.
Impact of the CAP ́s Second Pillar Budget Reform on the Czech Economy
Creators: name: Kristkova, Zuzana
name: Ratinger, Tomas
name: Kristkova, Zuzana
name: Ratinger, Tomas
Publisher: name: Unknown
Year: 2012
Subjects: subject: Environmental Economics and Policy
subject: Political Economy
subject: Common Agricultural Policy
subject: Second pillar
subject: budget
subject: investment subsidies
subject: CGE model
subject: simulation
subject: agriculture.

description: In this paper, three scenarios concerning different budget options of the reformed CAP are analysed based on the general equilibrium approach. The simulations consider a policy shock in 2014 and assess its impact until 2020. The results suggest that the changes in financing the second pillar CAP will produce only marginal effects on the economy. However, the reallocation of funds from the first to the second pillar has considerably larger negative effects on gross value added and employment in agriculture than the case of the second pillar budget reduction. On the other hand, the reallocation of funds will produce small but positive effects on the remaining sectors of the economy and the GDP. Research presented in this paper is the result of a research grant MSM 6046070906 “Economics of Czech agricultural resources and their efficient usage within the framework of multifunctional agri-food systems” and a Research Task of UZEI conducted for the Ministry of Agriculture TÚ 4241/2011”.
TUBERCULOSE OCULAR: A IMPORTÂNCIA DA CORTICOTERAPIA SISTÉMICA – CASO CLÍNICO
Creators: name: Gomes, Irina Ramos
name: Nogueira, Vanda Mesquita
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Objetivos: Relato de caso clínico de um doente com diagnóstico prévio de tuberculose e panuveíte no olho esquerdo (OE) e neurorretinite bilateral. Material e Métodos: Homem, 40 anos, origem africana, diagnóstico de tuberculose hepática e ganglionar sob tratamento com antibacilares há 3 meses com remissão completa da sintomatologia sistémica. Observado pela primeira vez com história de hiperémia conjuntival bilateral e diminuição da AV com metamorfopsias OE com 4 meses de evolução. À observação, MAVC OD: 10/10 e MAVC OE: 8/10; uveíte anterior granulomatosa OE com precipitados endoteliais, câmara anterior com flare e células 3+, nódulos de Koeppe e Busacca e sinéquia posterior; edema do disco ótico bilateral, vitrite e edema macular OE e lesões coroideias nos quadrantes inferiores ODE. Iniciou tratamento com corticosteróide e midriático/cicloplégico tópicos. Resultados: Uma semana depois, a MAVC OE melhorou para 10/10, com melhoria da inflamação no segmento anterior e remissão completa dos nódulos iridianos. A RM-CE excluiu lesão do sistema nervoso central e a perimetria estática computadorizada não revelou alterações ODE. A angiografia fluoresceínica mostrou difusão de contraste macular OE e difusão do disco ótico ODE. A tomografia de coerência ótica (OCT) confirmou edema macular OE. A angiografia com verde de indocianina revelou áreas com inflamação coroideia. Iniciou-se corticoterapia oral com remissão completa da inflamação do segmento posterior e do nervo ótico. Conclusões: Apesar da resposta sistémica completa com o tratamento antibacilar, a remissão da inflamação ocular só foi alcançada após implementação de corticoterapia sistémica, destacando a sua importância na terapêutica da tuberculose ocular.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
CORRELAÇÃO DA CLÍNICA NA RETINOPATIA PURTSCHER COM A TOMOGRAFIA DE COERÊNCIA ÓTICA - CASO CLÍNICO
Creators: name: Soares, Andreia
name: Freitas, Rui
name: Galvão-Santos, Gil
name: Sousa, Keissy
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Introdução: A retinopatia de Purtscher é uma vasculopatia oclusiva reportada inicialmente em doentes com traumatismo craneano severo. Posteriormente outras causas foram documentadas, mas a ausência de trauma ocular direto é uma condição para o estabelecimento diagnóstico. O seu aparecimento é variável, entre dias a meses após o evento inicial. O diagnóstico é clínico, podendo ser suportado com outros meios complementares de diagnóstico. Apresenta-se o caso clínico de um paciente com retinopatia de Purtscher. Caso clínico: Homem de 41 anos, politraumatizado, vítima de atropelamento com trauma pélvico e fratura mandibular. Seis dias após o internamento inicia queixas de diminuição da acuidade visual do OE(AV OE), com AV de conta dedos(CD). O segmento anterior não apresentava alterações. Na fundoscopia observavam-se múltiplas manchas algodonosas peripapilares, áreas de palidez retiniana(Purtschen fleckens), com hemorragia retrohialoideia e intrarretiniana foveal. Não foi realizada qualquer terapêutica. A tomografia de coerência ótica(OCT) mostrou uma hiperrefletividade peripapilar correspondente às áreas esbranquiçadas da retina e uma hiporrefletividade ao nível da retina interna na área perifoveal, correspondente à hemorragia macular observada. Aos dez meses após o diagnóstico a AV é de 2/10+, no fundo ocular observam-se reabsorção dos achados clínicos e no OCT observa-se atrofia difusa da camada neurossensorial da retina e diminuição da camada de fibras nervosas peripapilares. Conclusão: A retinopatia de Purtscher é uma condição rara cujo diagnóstico é clínico e suportado por outros meios complementares. O OCT mostra diminuição da retina neurossensorial e da camada de fibras nervosas, concordantes com o prognóstico visual do doente.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
Additional file 4 of Six polymorphisms in the lncRNA H19 gene and the risk of cancer: a systematic review and meta-analysis
Creators: name: Yang, Maoquan
name: Zhang, Mingwei
name: Wang, Qiong
name: Guo, Xiaojing
name: Geng, Peizhen
name: Gu, Jinhua
name: Ji, Wansheng
name: Zhang, Li
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Supplementary Material 4
Additional file 7 of Diverse coping modes of maize in cool environment at early growth
Creators: name: Sowiński, Paweł
name: Wieliczko-Manowska, Katarzyna
name: Grzybowski, Marcin
name: Jończyk, Maciej
name: Sowiński, Jakub
name: Sobkowiak, Alicja
name: Kowalec, Piotr
name: Rogacki, Janusz
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 7. List of inbred lines used in Experiment II.
The "forbidden" decays of hybrid mesons to $πρ$ can be large
Creators: name: Close, F. E.
name: Dudek, J. J.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The observation of $π_1(1600) \to πρ$ is shown in the flux-tube model to be compatible with this state being a hybrid meson with branching ratio to this channel $\sim 30%$. The $πρ$ widths of other hybrids are related by rather general arguments. These results enable cross sections for photoproduction of hybrids to be predicted.
description: Replaced with revised version correcting a technical mistake, conclusions remain unchanged. Accepted for publication in PRD
Neotrichaphodioides Dellacasa & Dellacasa & Skelley 2010, new genus
Creators: name: Dellacasa, Marco
name: Dellacasa, Giovanni
name: Skelley, Paul E.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Aphodiidae
Neotrichaphodioides

description: Neotrichaphodioides new genus
 Type species. Aphodius volxemi Harold, 1876, by present designation.
 Diagnosis. Small or medium size species (length 3.5-8.0 mm), oblong, moderately convex, few specimens are glossy, glabrous; rarely apical half of male elytra with short, dense pubescence. Piceous, brownish-red or brownish-yellow, sometimes elytra cloudy darkened on disc. Head with epistome almost flat, sparsely punctulate; clypeus almost semicircular or subtruncate anteriorly, widely rounded at sides, glabrous; genae acutely angulate or obtusely rounded, not to very shortly bristled, more or less strongly protruding; frontal suture finely impressed, mutic. Pronotum transverse, feebly convex, evenly or dually punctured; hind angles subtruncate; base not bordered. Scutellum small, triangularly elongate. Elytra oval, denticulate or not at shoulder, deeply finely striate; intervals flat or more or less strongly convex, microreticulate, sparsely punctured. Fore tibiae distally tridentate, proximally serrulate at outer margin; upper side sparsely distinctly punctured. Hind tibiae with feeble transverse carinae on outer face; apically fimbriate with spinules elongate and irregularly strongly unequal. Pygidium sparsely roughly punctured; each puncture with a short recumbent hair; apical margin with few, sparse and elongate straight setae. Sexual dimorphism shown in males mostly by wider head and pronotum, the short and widened segments of the labial palpi, elytral intervals sometimes with short dense pubescence, fore tibiae apical spur short, stout and abruptly bent downward, and metasternal plate deeply excavate, densely punctured and pubescent. Aedeagus with parameres short, with a preapical tuft of more or less elongate, sometimes exceptionally elongate hairs. Epipharynx with anterior margin deeply sinuate at middle, widely rounded at sides; epitorma shortly conical; corypha with two apical strong and elongate spiculae protruding beyond front margin; pedia densely pubescent, with few elongate, stout, antero-lateral spines subserially arranged; chaetopariae slender, moderately elongate and densely arranged.
 Distribution. Neotropical Region.
 Etymology. The generic name (gender masculine) is based on the first three letters of “Neotropical” followed by the generic name Trichaphodioides.
description: Published as part of Dellacasa, Marco, Dellacasa, Giovanni & Skelley, Paul E., 2010, Neotrichaphodioides, new genus of Neotropical Aphodiini, with description of a new species from Peru (Scarabaeoidea: Scarabaeidae: Aphodiinae), pp. 1-12 in Insecta Mundi 2010 (133) on pages 2-3, DOI: 10.5281/zenodo.5164776
PROLIFERAÇÃO EPIRRETINIANA ASSOCIADA A BURACOS LAMELARES: IMPLICAÇÕES CLÍNICAS E CIRÚRGICAS
Creators: name: Marques, Marco Frederico
name: Rodrigues, Sónia
name: Raimundo, Miguel
name: Marques, João Pedro
name: Alfaiate, Mário
name: Figueira, João
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: OBJETIVOS Descrever a prevalência de proliferação epirretiniana (PER) nos buracos maculares lamelares (BML), e correlacionar esta alteração com a morfologia do BML e prognóstico anatómico e funcional após abordagem cirúrgica ou conservadora. MÉTODOS Série de casos retrospetiva, multicêntrica, que incluiu doentes consecutivos diagnosticados com BML e seguidos por ≥6 meses. Observaram-se todas as tomografias de coerência ótica (OCT), onde se avaliaram: presença de membrana epirretiniana (MER) e PER, espessura do pavimento foveal, maior diâmetro e maior diâmetro da porção interna do BML. Nos doentes operados efetuou-se vitrectomia via pars plana com pelagem de MER e membrana limitante interna e tamponamento interno com SF6. RESULTADOS Foram incluídos 62 olhos (57 doentes), seguidos durante 27,1±19,8 meses, sendo objetivada PER em 33 (53,2%) deles. Comparativamente aos BML sem PER, naqueles com PER objetivou-se um diâmetro significativamente maior (p=0,001), menor espessura do leito (p=0,018), e uma menor razão do diâmetro das camadas internas pelo maior diâmetro (p=0,002). Vinte e sete (81,8%) dos BML com PER apresentaram conformação em tenda, com aproximação dos bordos internos, comparativamente a 23,3% dos BML sem PER. No subgrupo de 13 doentes operados, não se notaram diferenças na performance visual (p=0,687) ou taxa de encerramento (p=0,569) entre os dois grupos nos olhos operados. CONCLUSÕES As PER são entidades descritas recentemente que alteram a fisionomia do BML, com maiores diâmetros máximos nas camadas intermédias e menor espessura do leito. Não se encontraram diferenças na performance visual ou taxa de encerramento do BML nos olhos com PER operados ou seguidos conservadoramente.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
title: Toetsing kunstwerken in kusthavens: Deelrapport 2. Golfbelasting Visserijsluis
Creators: name: Vanneste, Dieter
name: Nguyen, Duc Anh
name: De Roo, Sieglien
name: Suzuki, Tomohiro
Publisher: name: Flanders Hydraulics Research
Year: 2022

description: Title : WL Rapporten. Waterbouwkundig Laboratorium: Antwerpen. Volume : 20_025_2 Issue : Pagination : VIII, 41 + 42 bijl.
Additional file 8 of Diverse coping modes of maize in cool environment at early growth
Creators: name: Sowiński, Paweł
name: Wieliczko-Manowska, Katarzyna
name: Grzybowski, Marcin
name: Jończyk, Maciej
name: Sowiński, Jakub
name: Sobkowiak, Alicja
name: Kowalec, Piotr
name: Rogacki, Janusz
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 8. List of inbred lines used in Experiment III.
ESPESSURA DA CORÓIDE NA DOENÇA DE ALZHEIMER VERSUS ENVELHECIMENTO
Creators: name: Proença, Rita Pinto
name: Cunha, João Paulo
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Introdução: Os fatores vasculares desempenham um papel importante na patogénese da doença de Alzheimer (DA). O estreitamento dos vasos da retina está amplamente descrito na literatura mas, no entanto, as alterações da coróide nesta doença estão ainda pouco descritas e ainda menos compreendidas. Os autores têm como objetivo medir a espessura da coróide em 13 localizações diferentes, centrifugas à fóvea, com recurso ao EDI-OCT (Enhanced Depth Imaging - Optical Coherence Tomography), e comparar a espessura da coróide em doentes com DA com a de indivíduos normais mais idosos. Métodos: Estudo observacional transversal que incluiu cinquenta olhos de 50 doentes com diagnóstico de DA, com uma idade média de 73 anos (DP±5,36) e 50 olhos de 50 indivíduos controlo muito idosos, com média de idade de 82,14 (DP±3,67). Todos os indivíduos foram submetidos a avaliação neuropsicológica e oftalmológica. As imagens da coróide foram obtidas por EDI-OCT. A espessura da coróide foi medida de forma manual, subfovealmente, e em intervalos de 500 µm até 1,5 mm temporal, nasal, superior e inferior à fóvea. A análise estatística foi realizada para avaliar variações de espessura da coróide em cada localização. Resultados: Observou-se uma tendência generalizada para a diminuição da espessura da coróide nos doentes com DA face aos doentes muito idosos (137,60 a 179,50µm versus 156,34 a 190,44µm, respetivamente). Esta tendência teve significância estatística em 3 localizações: subfoveal, 500 e 1000 µm temporais à fóvea (p <0,05). Conclusão: Os doentes com DA mostraram uma redução estatisticamente significativa da espessura da coroideia em 3 das localizações estudadas. Este adelgaçamento coróideu pode refletir a importância do factor vascular na patogénese desta doença, e representar mais um biomarcador para o diagnóstico da distinto do envelhecimento.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
Dimensional schemes for cross sections at NNLO
Creators: name: Gnendiger, Christoph
name: Signer, Adrian
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: So far, the use of different variants of dimensional regularization has been investigated extensively for two-loop virtual corrections. We extend these studies to real corrections that are also required for a complete computation of physical cross sections at next-to-next-to-leading order. As a case study we consider two-jet production in electron-positron annihilation and describe how to compute the various parts separately in different schemes. In particular, we verify that using dimensional reduction the double-real corrections are obtained simply by integrating the four-dimensional matrix element over the phase space. In addition, we confirm that the cross section is regularization-scheme independent.
description: 20 pages, 2 figures
Simplified disease activity index and clinical disease activity index before and during pregnancy correlate with those at postpartum in patients with rheumatoid arthritis
Creators: name: Nakamura, Eri
name: Kotani, Takuya
name: Hiramatsu, Yuri
name: Hata, Kenichiro
name: Yoshikawa, Ayaka
name: Matsumura, Yoko
name: Tokai, Nao
name: Wada, Yumiko
name: Fujita, Daisuke
name: Takeuchi, Tohru
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: We explored rheumatoid arthritis (RA) disease activity before, during, and after pregnancy in patients treated with tight control and investigated the association between disease activity in the postpartum period and those before and during pregnancy. We retrospectively reviewed disease activity and medications of 27 patients before pregnancy, at every trimester, and in the postpartum period. Prednisolone was administered to 33% of patients with a median dose of 0 (0–2.5) mg/day and biologic agents was 78% in the third trimester. The median remission rates during all periods were the Disease Activity Score-28-C-reactive Protein assessed with three variables (DAS28-CRP-3) 85%, Simplified Disease Activity Index (SDAI) 55%, and Clinical Disease Activity Index (CDAI) 54%. Although SDAI and CDAI decreased significantly from before pregnancy to the first trimester and increased from the third trimester to the postpartum period, DAS28-CRP-3 did not change during all periods. Although SDAI and CDAI before and during pregnancy were significantly correlated with those in the postpartum period, DAS28-CRP-3 was not. Tight control before pregnancy suppressed RA disease activity during pregnancy and in the postpartum period. SDAI/CDAI before and during pregnancy were predictive for disease activity in the postpartum period.
Effects of glycosaminoglycan supplementation in the chondrogenic differentiation of bone marrow- and synovial- derived mesenchymal stem/stromal cells on 3D-extruded poly (ε-caprolactone) scaffolds
Creators: name: Silva, João C.
name: Moura, Carla S.
name: Borrecho, Gonçalo
name: Matos, António P. Alves De
name: Cabral, Joaquim M. S.
name: Linhardt, Robert J.
name: Ferreira, Frederico Castelo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: The lack of effective and long-term treatments for articular cartilage defects has increased the interest for innovative tissue engineering strategies. Such approaches, combining cells, biomaterial matrices and external biochemical/physical cues, hold promise for generating fully functional cartilage tissue. Herein, this study aims at exploring the use of the major cartilage glycosaminoglycans (GAGs), chondroitin sulfate (CS) and hyaluronic acid (HA), as external biochemical cues to promote the chondrogenic differentiation of human bone marrow- and synovium-derived mesenchymal stem/stromal cells (hBMSC/hSMSC) on custom-made 3 D porous poly (ε-caprolactone) (PCL) scaffolds. The culture conditions, namely the chondrogenic medium and hypoxic environment (5% O2 tension), were firstly optimized by culturing hBMSCs on PCL scaffolds without GAG supplementation. For both MSC sources, GAG supplemented media, particularly with HA, promoted significantly cartilage-like extracellular matrix (ECM) production (higher sulfated GAG amounts) and chondrogenic gene expression. Remarkably, in contrast to tissues generated using hBMSCs, the hSMSC-based constructs showed decreased expression of hypertrophic marker COL X. Histological, immunohistochemical and transmission electron microscopy (TEM) analysis confirmed the presence of typical articular cartilage ECM components (GAGs, aggrecan, collagen fibers) in all the tissue constructs produced. Overall, our results highlight the potential of integrating GAG supplementation, hSMSCs and customizable 3 D scaffolds toward the fabrication of bioengineered cartilage tissue substitutes with reduced hypertrophy.
How to conduct cost and value analyses in health professions education: AMEE Guide No. 139
Creators: name: Foo, Jonathan
name: Cook, David A.
name: Tolsgaard, Martin
name: Rivers, George
name: Cleland, Jennifer
name: Walsh, Kieran
name: Abdalla, Mohamed Elhassan
name: You, You
name: Ilic, Dragan
name: Golub, Robert
name: Levin, Henry
name: Maloney, Stephen
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Growing demand for accountability, transparency, and efficiency in health professions education is expected to drive increased demand for, and use of, cost and value analyses. In this AMEE Guide, we introduce key concepts, methods, and literature that will enable novices in economics to conduct simple cost and value analyses, hold informed discussions with economic specialists, and undertake further learning on more advanced economic topics. The practical structure for conducting analyses provided in this guide will enable researchers to produce robust results that are meaningful and useful for improving educational practice. Key steps include defining the economic research question, identifying an appropriate economic study design, carefully identifying cost ingredients, quantifying, and pricing the ingredients consumed, and conducting sensitivity analyses to explore uncertainties in the results.
INDICAÇÕES E RESULTADOS DE COLÍRIO DE CICLOSPORINA A – ESTUDO RETROSPETIVO DE 6 ANOS
Creators: name: Pinto, Joana Medeiros
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Introdução: A ciclosporina A (CsA) tem sido utilizada com eficácia e segurança no tratamento de várias patologias da superfície ocular dependentes de corticoterapia tópica, evitando os seus efeitos indesejáveis. O objetivo deste trabalho foi descrever e analisar as indicações e resultados da utilização do colírio de CsA a 1% nos últimos 6 anos no Hospital de Santa Maria. Material e métodos: Análise retrospetiva dos processos clínicos de todos os doentes que iniciaram tratamento com colírio de CsA a 1% no Serviço de Oftalmologia do Hospital de Santa Maria entre 2009 e 2015. Resultados: Foram incluídos 104 olhos de 62 doentes, com idade média 36±24 anos. As indicações para utilização de CsA a 1% foram: queratoconjuntivite vernal (QCV) (36%), profilaxia ou tratamento de rejeição de enxerto querático (19%), olho seco (15%), queratite numular (11%), doença do enxerto contra hospedeiro (DECH) (6.5%) e outros (13%). Previamente à utilização de CsA, 84% dos doentes receberam tratamento com corticoide tópico. Nestes, foi possível a sua suspensão em 71% dos casos. Verificou-se maior eficácia na suspensão de corticoide tópico na QCV (91%) e na queratite numular (86%). A CsA foi suspensa por intolerância em 9 doentes (15%), 5 dos quais com olho seco. Conclusões: A CsA a 1% tópica mostrou-se sobretudo eficaz no tratamento de QCV. Pode ser também uma boa opção terapêutica na queratite numular, apesar de se ter verificado recorrência após descontinuação da CsA na maioria dos doentes. A tolerância foi baixa nos doentes com olho seco.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
Possible background reductions in double beta decay experiments
Creators: name: Arnold, R.
name: Augier, C.
name: Baker, J.
name: Barabash, A.
name: Bing, O.
name: Brudanin, V.
name: Caffrey, A. J.
name: Caurier, E.
name: Errahmane, K.
name: Etienvre, A. -I.
name: Guyonnet, J. L.
name: Hubert, F.
name: Hubert, Ph.
name: Jollet, C.
name: Jullian, S.
name: Kochetov, O.
name: Kovalenko, V.
name: Lalanne, D.
name: Leccia, F.
name: Longuemare, C.
name: Marquet, Ch.
name: Mauger, F.
name: Nicholson, H. W.
name: Ohsumi, H.
name: Piquemal, F.
name: Reyss, J-L.
name: Sarazin, X.
name: Shitov, Yu.
name: Simard, L.
name: Stekl, I.
name: Suhonen, J.
name: Sutton, C. S.
name: Szklarz, G.
name: Timkin, V.
name: Tretyak, V.
name: Umatov, V.
name: Vala, L.
name: Vanyushin, I.
name: Vasilyev, V.
name: Vorobel, V.
name: Vylov, Ts.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The background induced by radioactive impurities of $^{208}\rm Tl$ and $^{214}\rm Bi$ in the source of the double beta experiment NEMO-3 has been investigated. New methods of data analysis which decrease the background from the above mentioned contamination are identified. The techniques can also be applied to other double beta decay experiments capable of measuring independently the energies of the two electrons.
description: 15 pages, 13 figures, accepted in the Nuclear Instruments and Methods A
Future Proofing a Building Design Using History Matching Inspired Level-Set Techniques
Creators: name: Baker, Evan
name: Challenor, Peter
name: Eames, Matt
Publisher: name: arXiv
Year: 2020
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: History Matching is a technique used to calibrate complex computer models, that is, finding the input settings which lead to the simulated output matching up with real world observations. Key to this technique is the construction of emulators, which provide fast probabilistic predictions of future simulations. In this work, we adapt the History Matching framework to tackle the problem of level set estimation, that is, finding input settings where the output is below (or above) some threshold. The developed methodology is heavily motivated by a specific case study: how can one design a building that will be sufficiently protected against overheating and sufficiently energy efficient, whilst considering the expected increases in temperature due to climate change? We successfully manage to address this - greatly reducing a large initial set of candidate building designs down to a small set of acceptable potential buildings.
description: 19 pages, 3 figures
Gaia DR2 distances to Collinder 419 and NGC 2264 and new astrometric orbits for HD 193 322 Aa,Ab and 15 Mon Aa,Ab
Creators: name: Apellániz, J. Maíz
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: [ABRIDGED] CONTEXT: Gaia DR2 has opened a trove of astrometric and photometric data for Galactic clusters close to the Sun. Lucky imaging has been an operational technique to measure the positions of visual binary systems for a decade and a half, enough to apply its results to the calculation of orbits of some massive multiple systems within ~1 kpc of the Sun. AIMS: We are measuring distances to Galactic stellar groups containing O stars and I start with two of them: Collinder 419 in Cygnus and NGC 2264 in Monoceros. I also aim to derive new astrometric orbits for the Aa,Ab components for the main ionizing sources for both clusters: HD 193 322 and 15 Mon, respectively. METHODS: First, I present a method that uses Gaia DR2 photometry, positions, proper motions, and parallaxes to obtain the membership and distance of a stellar group and apply it to Collinder 419 and NGC 2264. Second, I present a new code that calculates astrometric orbits by searching the whole 7-parameter orbit space and apply it to HD 193 322 Aa,Ab and 15 Mon Aa,Ab using as input literature data from the Washington Double Star Catalog (WDS) and the AstraLux measurements recently presented by Maíz Apellániz et al. (2019). RESULTS: I obtain Gaia DR2 distances of 1006+37-34 pc for Collinder 419 and 719+-16 pc for NGC 2264, with the main contribution to the uncertainties coming from the spatial covariance of the parallaxes. The two NGC 2264 subclusters are at the same distance (within the uncertainties) and they show a significant relative proper motion. The distances are shown to be robust. HD 193 322 Aa,Ab follows an eccentric (e = 0.58+0.03-0.04) orbit with a period of 44+-1 a and the three stars it contains have a total mass of 76.1+9.9-7.4 M_Sol. The orbit of 15 Mon Aa,Ab is even more eccentric (e = 0.770+0.023-0.030), with a period of 108+-12 a and a total mass of 45.1+3.6-3.3 M_Sol for its two stars.
description: Accepted for publication in A&A
AVALIAÇÃO DA CAMADA DE CÉLULAS GANGLIONARES DA RETINA: UM FACTOR A CONSIDERAR NO EDEMA MACULAR DIABÉTICO TRATADO
Creators: name: Loureiro, Monica
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Introdução: No edema macular diabético (EMD) tratado a resolução do EM com restauração do contorno foveal normal, nem sempre é acompanhada de melhoria da acuidade visual (AV). O objetivo do estudo é avaliar a camada de células ganglionares da retina (CCGR) no EMD tratado e correlacionar com a recuperação funcional. Métodos: Estudo caso-controlo entre doentes com EMD tratado (sem EM após tratamento, contorno foveal normal e espessura macular central (EMC) <321µm) e doentes diabéticos sem história de EMD (controlos). A avaliação da EMC e da espessura da CCGR foi feita com o volume scan de 19 linhas do SD-OCT e apresentada segundo a grelha ETDRS. A informação referente ao sexo, idade, valor da hemoglobina glicada, status do cristalino, classificação da retinopatia diabética, tratamentos oftalmológicos prévios e AV, também foi avaliada. Resultados: A EMC média no grupo de EMD tratado foi de 284.9±33.6µm, enquanto o valor correspondente no grupo controlo foi de 284.8±31.0µm (p=0.96). A MAVC no grupo do EMD tratado (0.57±0.2) mostrou ser inferior à do grupo controlo (0.81±0.16, p<0.001). De forma semelhante, a espessura da CCGR no EMD tratado (16.8±4.8µm) foi significativamente menor que a do controlo (21.3±7.6µm, p=0.008). No grupo de doentes com EMD tratado, a EMC teve uma correlação positiva moderada com a MAVC (r=0.5, p<0.001); enquanto a espessura da CCGR evidenciou uma correlação positiva forte (r=0.7, p<0.001). Conclusão: No EMD tratado apesar da normalização da EMC, a espessura da CCGR é significativamente menor que nos controlos e está fortemente correlacionada com a resposta funcional, sendo portanto um fator a considerar na avaliação clínica desses doentes.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
Additional file 11 of Diverse coping modes of maize in cool environment at early growth
Creators: name: Sowiński, Paweł
name: Wieliczko-Manowska, Katarzyna
name: Grzybowski, Marcin
name: Jończyk, Maciej
name: Sowiński, Jakub
name: Sobkowiak, Alicja
name: Kowalec, Piotr
name: Rogacki, Janusz
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 11. The mean and standard deviation calculated for morphological parameters, spectral parameters, and spectral vegetation indices for all the experimental data.
Why the quantum?
Creators: name: Bub, Jeffrey
Publisher: name: arXiv
Year: 2004
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper is a commentary on the foundational significance of the Clifton-Bub-Halvorson theorem characterizing quantum theory in terms of three information-theoretic constraints (Foundations of Physics 33, 1561-1591 (2003); quant-ph/0211089). I argue that: (1) a quantum theory is best understood as a theory about the possibilities and impossibilities of information transfer, as opposed to a theory about the mechanics of nonclassical waves or particles, (2) given the information-theoretic constraints, any mechanical theory of quantum phenomena that includes an account of the measuring instruments that reveal these phenomena must be empirically equivalent to a quantum theory, and (3) assuming the information-theoretic constraints are in fact satisfied in our world, no mechanical theory of quantum phenomena that includes an account of measurement interactions can be acceptable, and the appropriate aim of physics at the fundamental level then becomes the representation and manipulation of information.
description: 23 pages, LaTeX. Forthcoming in Studies in the History and Philosophy of Modern Physics, 2004
Variabilidade intra e inter-observador da determinação da espessura média da coroideia medida por enhanced depth imaging (EDI)- OCT
Creators: name: Leal, Inês
name: Pinto, Filomena
name: Gala, Telma
name: Monteiro-Grillo, Manuel
name: Marques-Neves, Carlos
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2017

description: Introdução: Atualmente é possível medir manualmente a espessura da coroideia com enhanced depth imaging (EDI) OCT. O objectivo foi determinar a variabilidade intra e inter-observador de medições manuais da espessura da coroideia em olhos saudáveis com EDI-OCT. Material e Métodos: Estudo prospectivo duplamente oculto com 38 indivíduos saudáveis (72 olhos). Realizou-se EDI-OCT e a espessura coroideia foi medida manualmente por dois operadores duas vezes com um mês de intervalo nas localizações subfoveal (SF) e a 1000 μm temporal (T) e nasal (N) à fóvea, olho esquerdo (e) e direito (d). Análise com STATA v.13.0. Resultados: 38 indivíduos com idade média de 61.68±14 anos; espessura média da coroideia SF: 291.27±81.17, N: 265.49±77.15 e T: 284.30±78.26 μm. Testes t (α=0.05) sem diferenças significativas da espessura coroideia nas localizações SFd, SFe, Nd, Ne, Td e Te intra-observador ou SFd, SFe, Ne, Td e Te inter-observador (p>0.05). Observou-se uma diferença significativa nas medições Nd inter-observador (p=0.04). A correlação de Pearson foi mais forte nas medições intra-observador (média=0.995) do que inter-observador (média=0.948), p<0.01. Nas localizações SFd, SFe, Nd, Ne, Td, Te os valores de ICC intra-observador foram 0.99 e os inter-observador ≥0.94. Nas localizações SFd, SFe, Nd, Ne, Td e Te os valores de CCC intra-observador foram ≥0.810 e os inter-observador ≥0.939. Conclusões: As medições manuais da coroideia com EDI-OCT são altamente reproduzíveis e repetíveis em olhos saudáveis, com menores diferenças em medições intra-observador do que inter-observador.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 41 N.º 2 (2017)
Developing Employees Innovation Competence Through Organizational Development Intervention: A Case Study of Logis Company in China
Creators: name: Ma, Jie
Publisher: name: Graduate School of Business and Advanced Technology Management Assumption University Thailand
Year: 2024
Subjects: employees innovation competence
perceived innovative organizational culture
affective commitment
self-efficacy
tacit knowledge sharing
action research
organization development intervention

description: ABAC ODI Journal Vision. Action. Outcome, 12, 1, o1-20