cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Buried topological edge state associated with interface between topological band insulator and Mott insulator
Creators: name: Ishida, H.
name: Liebsch, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The electronic structure at the interface between a topological band insulator and a Mott insulator is studied within layer dynamical mean field theory. To represent the bulk phases of these systems, we use the generalized Bernevig-Hughes-Zhang model that incorporates the Hubbard-like onsite Coulomb energy U in addition to the spin-orbit coupling term that causes band inversion. The topological and Mott insulating phases are realized by appropriately choosing smaller and larger values of U, respectively. As expected, the interface is found to be metallic because of the localized edge state. When the Coulomb energy in the Mott insulator is close to the critical value, however, this edge state exhibits its largest amplitude deep within the Mott insulator rather than at the interface. This finding corresponds to a new type of proximity effect induced by the neighboring topological band insulator and demonstrates that, as a result of spin-orbit coupling within the Mott insulator, several layers near the interface convert from the Mott insulating phase to a topological insulating phase. Moreover, we argue that the ordinary proximity effect, whereby a Kondo peak is induced in a Mott insulator by neighboring metallic states, is accompanied by an additional reverse proximity effect, by which the Kondo peak gives rise to an enhancement of the density of states in the neighboring metallic layer.
description: 11 pages; 9 figures
Women's Education Level, Maternal Health Facilities, Abortion Legislation and Maternal Deaths: A Natural Experiment in Chile from 1957 to 2007
Creators: name: Koch, Elard
name: Aguilera, Hernán
name: Thorp, John
name: Ahlers, Ivonne
name: Gatica, Sebastián
name: Romero, Camila X.
name: Bravo, Miguel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: BackgroundThe aim of this study was to assess the main factors related to maternal mortality reduction in large time series available in Chile in context of the United Nations' Millennium Development Goals (MDGs).MethodsTime series of maternal mortality ratio (MMR) from official data (National Institute of Statistics, 1957–2007) along with parallel time series of education years, income per capita, fertility rate (TFR), birth order, clean water, sanitary sewer, and delivery by skilled attendants were analysed using autoregressive models (ARIMA). Historical changes on the mortality trend including the effect of different educational and maternal health policies implemented in 1965, and legislation that prohibited abortion in 1989 were assessed utilizing segmented regression techniques.ResultsDuring the 50-year study period, the MMR decreased from 293.7 to 18.2/100,000 live births, a decrease of 93.8%. Women's education level modulated the effects of TFR, birth order, delivery by skilled attendants, clean water, and sanitary sewer access. In the fully adjusted model, for every additional year of maternal education there was a corresponding decrease in the MMR of 29.3/100,000 live births. A rapid phase of decline between 1965 and 1981 (−13.29/100,000 live births each year) and a slow phase between 1981 and 2007 (−1.59/100,000 live births each year) were identified. After abortion was prohibited, the MMR decreased from 41.3 to 12.7 per 100,000 live births (−69.2%). The slope of the MMR did not appear to be altered by the change in abortion law.ConclusionIncreasing education level appears to favourably impact the downward trend in the MMR, modulating other key factors such as access and utilization of maternal health facilities, changes in women's reproductive behaviour and improvements of the sanitary system. Consequently, different MDGs can act synergistically to improve maternal health. The reduction in the MMR is not related to the legal status of abortion.
Fannie Mae's National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators-September, 2015 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
Lower bound of the tensor-to-scalar ratio $r \mathop{}_{\textstyle \sim}^{\textstyle >} 0.1$ in a nearly quadratic chaotic inflation model in supergravity
Creators: name: Harigaya, Keisuke
name: Kawasaki, Masahiro
name: Yanagida, Tsutomu T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider an initial condition problem in a nearly quadratic chaotic inflation model in supergravity. We introduce shift symmetry breaking not only in the superpotential but also in the Kahler potential. In this model the inflaton potential is nearly quadratic for inflaton field values around the Planck scale, but deviates from the quadratic one for larger field values. As a result, the prediction on the tensor-to-scalar ratio can be smaller than that of a purely quadratic model. Due to the shift symmetry breaking in the Kahler potential, the inflaton potential becomes steep for large inflaton field values, which may prevent inflation from naturally taking place in a closed universe. We estimate an upper bound on the magnitude of the shift symmetry breaking so that inflation takes place before a closed universe with a Planck length size collapses, which yields a lower bound on the tensor-to-scalar ratio, $r \mathop{}_{\textstyle \sim}^{\textstyle >} 0.1$.
description: 11 pages, 6 figures
4D Segmentation of Brain MR Images with Constrained Cortical Thickness Variation
Creators: name: Shi, Feng
name: Wang, Li
name: Shen, Dinggang
name: Li, Gang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Segmentation of brain MR images plays an important role in longitudinal investigation of developmental, aging, disease progression changes in the cerebral cortex. However, most existing brain segmentation methods consider multiple time-point images individually and thus cannot achieve longitudinal consistency. For example, cortical thickness measured from the segmented image will contain unnecessary temporal variations, which will affect the time related change pattern and eventually reduce the statistical power of analysis. In this paper, we propose a 4D segmentation framework for the adult brain MR images with the constraint of cortical thickness variations. Specifically, we utilize local intensity information to address the intensity inhomogeneity, spatial cortical thickness constraint to maintain the cortical thickness being within a reasonable range, and temporal cortical thickness variation constraint in neighboring time-points to suppress the artificial variations. The proposed method has been tested on BLSA dataset and ADNI dataset with promising results. Both qualitative and quantitative experimental results demonstrate the advantage of the proposed method, in comparison to other state-of-the-art 4D segmentation methods.
Collective impurity effects in the Heisenberg triangular antiferromagnet
Creators: name: Maryasin, V. S.
name: Zhitomirsky, M. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We theoretically investigate the Heisenberg antiferromagnet on a triangular lattice doped with nonmagnetic impurities. Two nontrivial effects resulting from collective impurity behavior are predicted. The first one is related to presence of uncompensated magnetic moments localized near vacancies as revealed by the low-temperature Curie tail in the magnetic susceptibility. These moments exhibit an anomalous growth with the impurity concentration, which we attribute to the clustering mechanism. In an external magnetic field, impurities lead to an even more peculiar phenomenon lifting the classical ground-state degeneracy in favor of the conical state. We analytically demonstrate that vacancies spontaneously generate a positive biquadratic exchange, which is responsible for the above degeneracy lifting.
description: 5 pages, as published
A Comparative Analysis of the Ubiquitination Kinetics of Multiple Degrons to Identify an Ideal Targeting Sequence for a Proteasome Reporter
Creators: name: Woss, Gregery S.
name: Park, Jessica H.
name: Dumberger, Lukas D.
name: Melvin, Adam T.
name: Allbritton, Nancy L.
name: Waters, Marcey L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The ubiquitin proteasome system (UPS) is the primary pathway responsible for the recognition and degradation of misfolded, damaged, or tightly regulated proteins. The conjugation of a polyubiquitin chain, or polyubiquitination, to a target protein requires an increasingly diverse cascade of enzymes culminating with the E3 ubiquitin ligases. Protein recognition by an E3 ligase occurs through a specific sequence of amino acids, termed a degradation sequence or degron. Recently, degrons have been incorporated into novel reporters to monitor proteasome activity; however only a limited few degrons have successfully been incorporated into such reporters. The goal of this work was to evaluate the ubiquitination kinetics of a small library of portable degrons that could eventually be incorporated into novel single cell reporters to assess proteasome activity. After an intensive literary search, eight degrons were identified from proteins recognized by a variety of E3 ubiquitin ligases and incorporated into a four component degron-based substrate to comparatively calculate ubiquitination kinetics. The mechanism of placement of multiple ubiquitins on the different degron-based substrates was assessed by comparing the data to computational models incorporating first order reaction kinetics using either multi-monoubiquitination or polyubiquitination of the degron-based substrates. A subset of three degrons was further characterized to determine the importance of the location and proximity of the ubiquitination site lysine with respect to the degron. Ultimately, this work identified three candidate portable degrons that exhibit a higher rate of ubiquitination compared to peptidase-dependent degradation, a desired trait for a proteasomal targeting motif.
Fannie Mae National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators- February, 2016 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
TURISTIK DESTINATSIYALARNING IJTIMOIY MEDIA FAOLIYATIDA KONTENT TAQSIMOTI
Creators: name: Xalimova, Nigina
Publisher: name: Zenodo
Year: 2024

description: Ijtimoiy mediada targ‘ibot – bu foydalanuvchi e’tiborini jalb qilish, auditoriyaning sodiqligini shakllantirish va uzoq vaqt davomida kompaniya yoki shaxsiy brendga qiziqishni saqlab qolish uchun foydalaniladigan istiqbolli va progressiv harakatlar jamlanmasi hisoblanadi. Muvaffaqiyatli tuzilgan kontent reja esa ushbu jamlanmaning kalitidir. Kontent – bu ijtimoiy mediada o‘z faoliyatini olib borayotgan shaxs, korxona, tashkilot, brend, destinatsiya olib chiqadigan mavzu. “Kontent marketingi esa – auditoriyani jalb qilish hamda e’tiborini tortish uchun yuqori darajada saviyali va zamonaviy kontentni yaratish hisoblanadi”
Organization capital and carbon performance
Creators: name: Provaty, Sagira Sultana
Publisher: name: Macquarie University
Year: 2023
Subjects: classificationCode: 350107
subject: Sustainability accounting and reporting

description: This study examines the impact of organization capital on carbon performance. Utilizing a sample of 3,817 firm-year observations of US publicly listed companies over the period from 2002 to 2019, I find that firms with higher organization capital are associated with lower carbon emission, signifying that high-organization capital firms are better-placed to utilize inimitable resources and competencies which in turn lead to improve firms’ carbon performance. In addition, I find that the magnitude of the negative relation between organization capital and carbon emission is more pronounced for firms with stronger corporate governance structures and lower financing constraints. Additionally, this relationship is more evident for firms operating in carbon sensitive industries and regions with an established ETS (Emissions Trading Scheme). This result survives after applying a range of robustness tests, including alternative specifications of carbon performance and organization capital, and the main finding is not driven by endogeneity concerns resulting from omitted variable bias, selection bias and reverse causality. To provide additional insights, I partition total carbon emissions into segments of direct and indirect emissions and find that high-organization capital firms tend to reduce both direct and indirect carbon emissions. Taken together, my analysis suggests that organization capital has considerable implications for corporate carbon performance.
A scalable method for molecular network reconstruction identifies properties of targets and mutations in acute myeloid leukemia
Creators: name: Ong, Edison
name: Szedlak, Anthony
name: Kang, Yunyi
name: Smith, Peyton
name: Smith, Nicholas
name: McBride, Madison
name: Finlay, Darren
name: Vuori, Kristiina
name: Mason, James
name: Ball, Edward D.
name: Piermarocchi, Carlo
name: Paternostro, Giovanni
Publisher: name: arXiv
Year: 2014
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: A key aim of systems biology is the reconstruction of molecular networks, however we do not yet have networks that integrate information from all datasets available for a particular clinical condition. This is in part due to the limited scalability, in terms of required computational time and power, of existing algorithms. Network reconstruction methods should also be scalable in the sense of allowing scientists from different backgrounds to efficiently integrate additional data. We present a network model of acute myeloid leukemia (AML). In the current version (AML 2.1) we have used gene expression data (both microarray and RNA-seq) from five different studies comprising a total of 771 AML samples and a protein-protein interactions dataset. Our scalable network reconstruction method is in part based on the well-known property of gene expression correlation among interacting molecules. The difficulty of distinguishing between direct and indirect interactions is addressed optimizing the coefficient of variation of gene expression, using a validated gold standard dataset of direct interactions. Computational time is much reduced compared to other network reconstruction methods. A key feature is the study of the reproducibility of interactions found in independent clinical datasets. An analysis of the most significant clusters, and of the network properties (intraset efficiency, degree, betweenness centrality and PageRank) of common AML mutations demonstrated the biological significance of the network. A statistical analysis of the response of blast cells from eleven AML patients to a library of kinase inhibitors provided an experimental validation of the network. A combination of network and experimental data identified CDK1, CDK2, CDK4 and CDK6 and other kinases as potential therapeutic targets in AML.
Fannie Mae National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators- March, 2016 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
A Genome-Wide Scan for Breast Cancer Risk Haplotypes among African American Women
Creators: name: Kolonel, Laurence N.
name: Ziegler, Regina G.
name: Haiman, Chris A.
name: Zheng, Wei
name: Deming, Sandra L.
name: Millikan, Robert C.
name: Van Den Berg, David J.
name: Bernstein, Leslie
name: Sheng, Xin
name: Nyante, Sarah
name: Bandera, Elisa V.
name: Stram, Daniel O.
name: Ingles, Sue A.
name: Chanock, Stephen J.
name: Song, Chi
name: Pooler, Loreall C.
name: Henderson, Brian E.
name: Chen, Gary K.
name: John, Esther M.
name: Le Marchand, Loic
name: Ambrosone, Christine B.
name: Hu, Jennifer J.
name: Rodriguez-Gil, Jorge L.
name: Wan, Peggy
name: Press, Michael F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Genome-wide association studies (GWAS) simultaneously investigating hundreds of thousands of single nucleotide polymorphisms (SNP) have become a powerful tool in the investigation of new disease susceptibility loci. Haplotypes are sometimes thought to be superior to SNPs and are promising in genetic association analyses. The application of genome-wide haplotype analysis, however, is hindered by the complexity of haplotypes themselves and sophistication in computation. We systematically analyzed the haplotype effects for breast cancer risk among 5,761 African American women (3,016 cases and 2,745 controls) using a sliding window approach on the genome-wide scale. Three regions on chromosomes 1, 4 and 18 exhibited moderate haplotype effects. Furthermore, among 21 breast cancer susceptibility loci previously established in European populations, 10p15 and 14q24 are likely to harbor novel haplotype effects. We also proposed a heuristic of determining the significance level and the effective number of independent tests by the permutation analysis on chromosome 22 data. It suggests that the effective number was approximately half of the total (7,794 out of 15,645), thus the half number could serve as a quick reference to evaluating genome-wide significance if a similar sliding window approach of haplotype analysis is adopted in similar populations using similar genotype density.
Fannie Mae National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators- April, 2016 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
On the formation of planetary systems via oligarchic growth in thermally evolving viscous discs
Creators: name: Coleman, Gavin A. L.
name: Nelson, Richard P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present N-body simulations of planetary system formation in thermally-evolving, viscous disc models. The simulations incorporate type I migration (including corotation torques and their saturation), gap formation, type II migration, gas accretion onto planetary cores, and gas disc dispersal through photoevaporation. The aim is to examine whether or not the oligarchic growth scenario, when combined with self-consistent disc models and up-to-date prescriptions for disc-driven migration, can produce planetary systems similar to those that have been observed. The results correlate with the initial disc mass. Low mass discs form close-packed systems of terrestrial-mass planets and super-Earths. Higher mass discs form multiple generations of planets, with masses in the range 10 < mp < 45M_Earth. These planets generally type I migrate into the inner disc, because of corotation torque saturation, where they open gaps and type II migrate into the central star. Occasionally, a final generation of low-to-intermediate mass planets forms and survives due to gas disc dispersal. No surviving gas giants were formed in our simulations. Analysis shows that these planets can only survive migration if a core forms and experiences runaway gas accretion at orbital radii r > 10 au prior to the onset of type II migration. We conclude that planet growth above masses mp > 10M_Earth during the gas disc life time leads to corotation torque saturation and rapid inward migration, preventing the formation and survival of gas giants. This result is in contrast to the success in forming gas giant planets displayed by some population synthesis models. This discrepancy arises, in part, because the type II migration prescription adopted in the population synthesis models causes too large a reduction in the migration speed when in the planet dominated regime.
description: 23 Pages, 21 Figures, accepted for publication in MNRAS
A Host Transcriptional Signature for Presymptomatic Detection of Infection in Humans Exposed to Influenza H1N1 or H3N2
Creators: name: Carin, Lawrence
name: Chen, Minhua
name: Woods, Christopher W.
name: Glickman, Seth
name: Ramsburg, Elizabeth
name: Gilbert, Anthony G.
name: Varkey, Jay
name: Huang, Yongsheng
name: Ginsburg, Geoffrey S.
name: McClain, Micah T.
name: Veldman, Timothy
name: Zaas, Aimee K.
name: Hero, Alfred O.
name: Nicholson, Bradly P.
name: Lucas, Joseph E.
name: Kingsmore, Stephen F.
name: Lambkin-Williams, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional pathogen-based testing for suspected upper respiratory viral infection. We inoculated human volunteers with either influenza A (A/Brisbane/59/2007 (H1N1) or A/Wisconsin/67/2005 (H3N2)), and assayed the peripheral blood transcriptome every 8 hours for 7 days. Of 41 inoculated volunteers, 18 (44%) developed symptomatic infection. Using unbiased sparse latent factor regression analysis, we generated a gene signature (or factor) for symptomatic influenza capable of detecting 94% of infected cases. This gene signature is detectable as early as 29 hours post-exposure and achieves maximal accuracy on average 43 hours (p = 0.003, H1N1) and 38 hours (p-value = 0.005, H3N2) before peak clinical symptoms. In order to test the relevance of these findings in naturally acquired disease, a composite influenza A signature built from these challenge studies was applied to Emergency Department patients where it discriminates between swine-origin influenza A/H1N1 (2009) infected and non-infected individuals with 92% accuracy. The host genomic response to Influenza infection is robust and may provide the means for detection before typical clinical symptoms are apparent.
A Novel Selection Marker for Efficient DNA Cloning and Recombineering in E. coli
Creators: name: Jang, Chuan-Wei
name: Magnuson, Terry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Production of recombinant DNA in bacterial cells is an essential technique in molecular biology. Plasmids are usually maintained in an E. coli host by antibiotic selection. However, there are only a few antibiotic-resistance markers available in common use. Here we report the adoption of a novel selection marker, mfabI (mutant fabI) for plasmid propagation in E. coli. mfabI expands the limited repertoire of selection markers and allows for more efficient molecular manipulation and plasmid propagation in E. coli. We show that mfabI is not only an efficient plasmid selection marker, but it also possesses unique activity that may facilitate molecular manipulation of unstable sequences. Furthermore, we have incorporated mfabI in the recombineering tool kit for generating mouse gene targeting vectors and demonstrate the advantage of using mfabI-containing recombineering vectors.
Directional Bilateral Filters
Creators: name: Venkatesh, Manasij
name: Seelamantula, Chandra Sekhar
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: We propose a bilateral filter with a locally controlled domain kernel for directional edge-preserving smoothing. Traditional bilateral filters use a range kernel, which is responsible for edge preservation, and a fixed domain kernel that performs smoothing. Our intuition is that orientation and anisotropy of image structures should be incorporated into the domain kernel while smoothing. For this purpose, we employ an oriented Gaussian domain kernel locally controlled by a structure tensor. The oriented domain kernel combined with a range kernel forms the directional bilateral filter. The two kernels assist each other in effectively suppressing the influence of the outliers while smoothing. To find the optimal parameters of the directional bilateral filter, we propose the use of Stein's unbiased risk estimate (SURE). We test the capabilities of the kernels separately as well as together, first on synthetic images, and then on real endoscopic images. The directional bilateral filter has better denoising performance than the Gaussian bilateral filter at various noise levels in terms of peak signal-to-noise ratio (PSNR).
MUTAXASSISLIK TILIDA TERMIN TUSHUNCHASINING QOʻLLANISH XUSUSIYATLARI
Creators: name: Begimov, Odil
Publisher: name: Zenodo
Year: 2024

description: Maqolada termin tushunchasi mutaxassislik tili uchun lingvistik tavsif obyekti sifatida oʻrganilgan. Terminning yuzaga kelishi jarayoni, uning xususiyatlari, hozirgi holati, xususan, ushbu tushunchaning lingvistik mohiyati koʻrsatilgan, shuningdek, terminning terminologik tizimida tushuncha sifatida belgilovchi mezonlarga aniqlik kiritilgan.
Fannie Mae National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators- May, 2016 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
A Quantitative System for Discriminating Induced Pluripotent Stem Cells, Embryonic Stem Cells and Somatic Cells
Creators: name: He, Qianchuan
name: Du, Ying
name: Wang, Anyou
name: Zhou, Chunxiao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Induced pluripotent stem cells (iPSCs) derived from somatic cells (SCs) and embryonic stem cells (ESCs) provide promising resources for regenerative medicine and medical research, leading to a daily identification of new cell lines. However, an efficient system to discriminate the different types of cell lines is lacking. Here, we develop a quantitative system to discriminate the three cell types, iPSCs, ESCs, and SCs. The system consists of DNA-methylation biomarkers and mathematical models, including an artificial neural network and support vector machines. All biomarkers were unbiasedly selected by calculating an eigengene score derived from analysis of genome-wide DNA methylations. With 30 biomarkers, or even with as few as 3 top biomarkers, this system can discriminate SCs from pluripotent cells (PCs, including ESCs and iPSCs) with almost 100% accuracy. With approximately 100 biomarkers, the system can distinguish ESCs from iPSCs with an accuracy of 95%. This robust system performs precisely with raw data without normalization as well as with converted data in which the continuous methylation levels are accounted. Strikingly, this system can even accurately predict new samples generated from different microarray platforms and the next-generation sequencing. The subtypes of cells, such as female and male iPSCs and fetal and adult SCs, can also be discriminated with this method. Thus, this novel quantitative system works as an accurate framework for discriminating the three cell types, iPSCs, ESCs, and SCs. This strategy also supports the notion that DNA-methylation generally varies among the three cell types.
A RhoC Biosensor Reveals Differences in the Activation Kinetics of RhoA and RhoC in Migrating Cells
Creators: name: Zawistowski, Jon S.
name: Hodgson, Louis
name: Danuser, Gaudenz
name: Hahn, Klaus M.
name: Sabouri-Ghomi, Mohsen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: RhoA and RhoC GTPases share 92% amino acid sequence identity, yet play different roles in regulating cell motility and morphology. To understand these differences, we developed and validated a biosensor of RhoC activation (RhoC FLARE). This was used together with a RhoA biosensor to compare the spatio-temporal dynamics of RhoA and RhoC activity during cell protrusion/retraction and macropinocytosis. Both GTPases were activated similarly at the cell edge, but in regions more distal from the edge RhoC showed higher activation during protrusion. The two isoforms differed markedly in the kinetics of activation. RhoC was activated concomitantly with RhoA at the cell edge, but distally, RhoC activation preceded RhoA activation, occurring before edge protrusion. During macropinocytosis, differences were observed during vesicle closure and in the area surrounding vesicle formation.
Fannie Mae National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators- June, 2016 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
Supplementary material from Size is relative: use of relational concepts by wild hummingbirds
Creators: name: Brown, Theo
name: Hurly, T. Andrew
name: Healy, Susan D.
name: Tello-Ramos, Maria C.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Further analyses and raw data
Determination of glucosinolates and isothiocyanates in glucosinolate-rich vegetables and oilseeds using infrared spectroscopy: A systematic review
Creators: name: Redha, Ali Ali
name: Torquati, Luciana
name: Langston, Faye
name: Nash, Geoffrey R.
name: Gidley, Michael J.
name: Cozzolino, Daniel
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Cruciferous vegetables and oilseeds are rich in glucosinolates that can transform into isothiocyanates upon enzymic hydrolysis during post-harvest handling, food preparation and/or digestion. Vegetables contain glucosinolates that have beneficial bioactivities, while glucosinolates in oilseeds might have anti-nutritional properties. It is therefore important to monitor and assess glucosinolates and isothiocyanates content through the food value chain as well as for optimized crop production. Vibrational spectroscopy methods, such as infrared (IR) spectroscopy, are used as a nondestructive, rapid and low-cost alternative to the current and common costly, destructive, and time-consuming techniques. This systematic review discusses and evaluates the recent literature available on the use of IR spectroscopy to determine glucosinolates and isothiocyanates in vegetables and oilseeds. NIR spectroscopy was used to predict glucosinolates in broccoli, kale, rocket, cabbage, Brussels sprouts, brown mustard, rapeseed, pennycress, and a combination of Brassicaceae family seeds. Only one study reported the use of NIR spectroscopy to predict broccoli isothiocyanates. The major limitations of these studies were the absence of the critical evaluation of errors associated with the reference method used to develop the calibration models and the lack of interpretation of loadings or regression coefficients used to predict glucosinolates.
Fannie Mae's National Housing Survey Monthly Home Purchase Sentiment Index (HPSI) and Key Indicators - July, 2016 (a subset of the complete monthly Fannie Mae National Housing Survey)
Creators: name: Foundation, Fannie Mae
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Economy on right/wrong track (1); personal financial situation (1); good/bad time to buy a house (1); good/bad time to sell a house (1); home price changes (3); rental price changes (3); mortgage interest rate changes (1); ability to obtain a home mortgage today (1); current homeownership status (1); renting vs. buying a home in the future (1); concern about unemployment (1); change in income (1).
High intake of cruciferous vegetables reduces the risk of gastrointestinal cancers: results from observational studies
Creators: name: Ren, Hong-Gang
name: Luu, Hung Nguyen
name: Liu, Ying
name: Wang, Dao Wen
name: Guo, Xingyi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The relationship between cruciferous vegetables (CV) and the risk of gastrointestinal (GI) cancers has been extensively investigated. However, epidemiologic investigations have produced inconsistent results. This meta-analysis investigated the association between CV intake and the risk of GI cancers. Due to the heterogeneity, fixed- or random-effects models were used for the analyses. The final analysis included 81 articles covering 89 studies. In comparison to the lowest consumption categories, the highest consumption categories of CV were associated with a lower risk for all GI cancers [rate ratio (RR): 0.81, 95% confidence interval (95% CI) 0.76–0.87]. Compared to a CV intake of 75 g/day, subjects with CV intake <75 g/day experienced a 7% reduction in risk (RR: 0.93; 95% CI: 0.84–0.96) for each 50 g increase in consumption. A negative correlation was identified between CV intake and the risk of esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer (CRC), but not gallbladder cancer (RR: 0.70; 95% CI: 0.38–1.27). High intake of broccoli and cabbage was associated with a decreased risk of gastric cancer (RR: 0.64; 95% CI: 0.47–0.87) and gallbladder cancer (RR: 0.46; 95% CI: 0.29–0.75). These results confirm the association between high intake of CV with a reduced risk of GI cancers.
Survey on Access to Archives. Questionnaires for Archives, Academics and NGOs
Creators: name: Friedewald, Michael
name: Szekely, Ivan
name: Karaboga, Murat
Publisher: name: Zenodo
Year: 2023
Subjects: access
archives
survey
questionnaire

description: These questionnaires were used for a survey undertaken in order to assess the current state of implementation of Recommendation R(2000)13 of the Committee of Ministers of Council of Europe to the member states on a European Policy on Access to Archives, adopted on 13 July 2000 and to identify current and future challenges regarding Access to Archives. It is a follow-up to the study "Access to Archives - A handbook of guidelines for implementing Recommendation No R(2000)13 on a European policy on access to archives" by Charles Kecskeméti and Iván Székely and published by the Council of Europe in 2005.
aBEAT: A Toolbox for Consistent Analysis of Longitudinal Adult Brain MRI
Creators: name: Wang, Yaping
name: Wu, Guorong
name: Shen, Dinggang
name: Wang, Li
name: Shi, Feng
name: Dai, Yakang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Longitudinal brain image analysis is critical for revealing subtle but complex structural and functional changes of brain during aging or in neurodevelopmental disease. However, even with the rapid increase of clinical research and trials, a software toolbox dedicated for longitudinal image analysis is still lacking publicly. To cater for this increasing need, we have developed a dedicated 4D Adult Brain Extraction and Analysis Toolbox (aBEAT) to provide robust and accurate analysis of the longitudinal adult brain MR images. Specially, a group of image processing tools were integrated into aBEAT, including 4D brain extraction, 4D tissue segmentation, and 4D brain labeling. First, a 4D deformable-surface-based brain extraction algorithm, which can deform serial brain surfaces simultaneously under temporal smoothness constraint, was developed for consistent brain extraction. Second, a level-sets-based 4D tissue segmentation algorithm that incorporates local intensity distribution, spatial cortical-thickness constraint, and temporal cortical-thickness consistency was also included in aBEAT for consistent brain tissue segmentation. Third, a longitudinal groupwise image registration framework was further integrated into aBEAT for consistent ROI labeling by simultaneously warping a pre-labeled brain atlas to the longitudinal brain images. The performance of aBEAT has been extensively evaluated on a large number of longitudinal MR T1 images which include normal and dementia subjects, achieving very promising results. A Linux-based standalone package of aBEAT is now freely available at http://www.nitrc.org/projects/abeat.
Abnormal MEG Oscillatory Activity during Visual Processing in the Prefrontal Cortices and Frontal Eye-Fields of the Aging HIV Brain
Creators: name: Knott, Nichole L.
name: Robertson, Kevin R.
name: Fox, Howard S.
name: Wilson, Tony W.
name: Heinrichs-Graham, Elizabeth
name: Swindells, Susan
name: Sandkovsky, Uriel
name: O’Neill, Jennifer
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: ObjectiveShortly after infection, HIV enters the brain and causes widespread inflammation and neuronal damage, which ultimately leads to neuropsychological impairments. Despite a large body of neuroscience and imaging studies, the pathophysiology of these HIV-associated neurocognitive disorders (HAND) remains unresolved. Previous neuroimaging studies have shown greater activation in HIV-infected patients during strenuous tasks in frontal and parietal cortices, and less activation in the primary sensory cortices during rest and sensory stimulation.MethodsHigh-density magnetoencephalography (MEG) was utilized to evaluate the basic neurophysiology underlying attentive, visual processing in older HIV-infected adults and a matched non-infected control group. Unlike other neuroimaging methods, MEG is a direct measure of neural activity that is not tied to brain metabolism or hemodynamic responses. During MEG, participants fixated on a centrally-presented crosshair while intermittent visual stimulation appeared in their top-right visual-field quadrant. All MEG data was imaged in the time-frequency domain using beamforming.ResultsUninfected controls had increased neuronal synchronization in the 6–12 Hz range within the right dorsolateral prefrontal cortex, right frontal eye-fields, and the posterior cingulate. Conversely, HIV-infected patients exhibited decreased synchrony in these same neural regions, and the magnitude of these decreases was correlated with neuropsychological performance in several cortical association regions.ConclusionsMEG-based imaging holds potential as a noninvasive biomarker for HIV-related neuronal dysfunction, and may help identify patients who have or may develop HAND. Reduced synchronization of neural populations in the association cortices was strongly linked to cognitive dysfunction, and likely reflects the impact of HIV on neuronal and neuropsychological health.
Morocco's Agricultural Economy in Brief
Creators: name: Santmyer, Carolee
name: Santmyer, Carolee
Publisher: name: Unknown
Year: 1968
Subjects: Agricultural and Food Policy
Crop Production/Industries
International Relations/Trade
Land Economics/Use
Livestock Production/Industries
Research and Development/Tech Change/Emerging Technologies

description: In 1956, the former French and Spanish protectorates, as well as the Free Zone of Tangier, were united to form the Kingdom of Morocco. Its capital is Rabat and its leading seaport is Casablanca. Morocco produces about one-fifth of the world's phosphates and is one of the world's leading citrus exporters. In 1965, agricultural products accounted for roughly 42 percent of its total exports by value. France is Morocco's leading trading partner, but Moroccan trade has recently tended to shift away from France toward other world markets. The United States normally supplies substantial amounts of grains and vegetable oils under the U.S. Food for Peace Program.
Accessory Gland as a Site for Prothoracicotropic Hormone Controlled Ecdysone Synthesis in Adult Male Insects
Creators: name: Jørgensen, Anne F.
name: Warren, James T.
name: Moeller, Morten E.
name: Andersen, Ole
name: Gilbert, Lawrence I.
name: Bengtsson, Meghan S.
name: Bordoy, Anna M.
name: Rewitz, Kim F.
name: Hentze, Julie L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Insect steroid hormones (ecdysteroids) are important for female reproduction in many insect species and are required for the initiation and coordination of vital developmental processes. Ecdysteroids are also important for adult male physiology and behavior, but their exact function and site of synthesis remains unclear, although previous studies suggest that the reproductive system may be their source. We have examined expression profiles of the ecdysteroidogenic Halloween genes, during development and in adults of the flour beetle Tribolium castaneum. Genes required for the biosynthesis of ecdysone (E), the precursor of the molting hormone 20-hydroxyecdysone (20E), are expressed in the tubular accessory glands (TAGs) of adult males. In contrast, expression of the gene encoding the enzyme mediating 20E synthesis was detected in the ovaries of females. Further, Spookiest (Spot), an enzyme presumably required for endowing tissues with competence to produce ecdysteroids, is male specific and predominantly expressed in the TAGs. We also show that prothoracicotropic hormone (PTTH), a regulator of E synthesis during larval development, regulates ecdysteroid levels in the adult stage in Drosophila melanogaster and the gene for its receptor Torso seems to be expressed specifically in the accessory glands of males. The composite results suggest strongly that the accessory glands of adult male insects are the main source of E, but not 20E. The finding of a possible male-specific source of E raises the possibility that E and 20E have sex-specific roles analogous to the vertebrate sex steroids, where males produce primarily testosterone, the precursor of estradiol. Furthermore this study provides the first evidence that PTTH regulates ecdysteroid synthesis in the adult stage and could explain the original finding that some adult insects are a rich source of PTTH.
Listening Boxes
Creators: name: Ferguson, John
name: Tomlinson, Vanessa
name: Nezovic, Sulja
Publisher: name: Griffith University
Year: 2022
Subjects: subject: 190499 Performing Arts and Creative Writing not elsewhere classified
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Sounds from the local environment are captured and presented in antiquated library drawers, which function as instruments for sonic exploration. The upcycled library catalogue houses the sounds of place, and provides a tangible visual metaphor for memories, triggers, and sonic transformations of the immediate environment. The ephemeral nature of sound is maintained, but the performative action of listening is highlighted. Listening Boxes is an open-ended work that is re-programmed to capture its environment whenever it is exhibited. (By Vanessa Tomlinson, John Ferguson, Sulja Raam Nezovic). This site-specific interactive installation suggests that sound and listening play an important role in how we understand the world. This project also celebrates technological minituraisation and embedded computing. The digital heart of Listening Boxes is a Bela cape and a single-board computer (Beaglebone Black), this runs bespoke software written in Pure data. Photoresistors sense the amount of light in each drawer as it is opened and closed, this is used to manipulate sound file playback. An additional breakout board provides multi-channel output, which is piped to loudspeakers via an amplification system that allows eight of the drawers to have unique sounds individually located within them. The remaining drawers contain acoustic-mechanical sound-making objects and visual stimuli relating to the local environment. Listening Boxes was created as part of Hidden Sounds 2018, a series of 7 sound installations curated by Clocked Out with funding from the Australia Council for the Arts. The installations were collaboratively developed by Erik Griswold, Vanessa Tomlinson, John Ferguson, Sulja Nezovic, Leah Barclay and Erkki Veltheim, in partnership with the Queensland Conservatorium Research Centre. Hidden Sounds have appeared as part of National Science Week and the Eco-Acoustics International Conference, installed at Tyalgum Music Festival, and presented at The Listening Museum III in association with Clocked Out and Urban Arts Project. Electronic, interactive, art installation using acoustic-mechanical sound-making objects. Included in event held at - 18/08/2018 and 19/08/2018 at QCGU as part of National Science Week and Eco-Acoustics International Conference. 07/09/2018-09/09/2018 at Tyalgum Music Festival. 21/09/2018 at the Listening Museum III.