cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The effects of the Americans with Disabilities Act on the health coverage and post-secondary education of people with disabilities
Creators: name: Honeycutt, Todd C.
Publisher: name: No Publisher Supplied
Year: 2010

description: In 1990, Congress passed the ADA to address many of the larger issues related to discrimination and access that individuals with disabilities face. A rich and varied literature has emerged on the ADA's effects on employment, and this study builds on that literature by focusing on whether the ADA, as an environmental factor, affected the relationship between having an activity limitation and having a participation restriction in either health coverage or post-secondary education. The study uses a difference-in-differences modeling approach to compare outcomes for individuals with and without limitations before and after the ADA was implemented, and also capitalizes on a natural experiment resulting from differences in state laws protecting people with disabilities. The key results are as follows: 1) for the working-age population, individuals with limitations had a shift in their health coverage away from private health insurance (such as from an employer) and toward public coverage (such as Medicaid or Medicare) that was largely related to a rise in federal disability benefits rather than the ADA; 2) full-time workers with limitations (particularly those working for private for-profit firms) had a decline in their employer-based health insurance rates after the ADA was implemented, and the effect was larger in states where the ADA represented an addition to existing state law, which is consistent with the ADA having a perverse effect; and 3) the ADA did not improve post-secondary educational enrollment among individuals with limitations, though younger adults with a high school education had an increase in college enrollment after the ADA was implemented. While the ADA addressed barriers for people with disabilities regarding discrimination and access, it provided no supports to address additional barriers to participation, such as having less education and fewer resources. Future policies to promote the economic independence of people with disabilities should build on the ADA to address such barriers, particularly those regarding financial costs. Two such policies would be to implement broad health care reform (such as implemented in Massachusetts) and provide more post-secondary education funding.
Early identification of the nosocomial spread of vancomycin-resistant Enterococcus faecium by Fourier-transform infrared spectroscopy and performance comparison with PFGE and WGS
Creators: name: Pitart, Christina
name: Piquet, Maria
name: Burgwinkel, Tessa
name: Del Pino, Rocío Arazo
name: Rubio, Marc
name: Aguilar, Mereia
name: De Gea, Sergi
name: Pulgarín, Andrea
name: Campo, Irene
name: Torralbo, Blanca
name: Parejo, Romina
name: Valls, Silvia
name: Fortes, Isabel
name: Santana, Gemina
name: Rubio, Elisa
name: Vilella, Anna
name: Del Río, Ana
name: Martínez, José Antonio
name: Miró, Elisenda
name: Navarro, Ferran
name: Espasa, Mateu
name: Casals-Pascual, Climent
name: Vila, Jordi
name: Higgins, Paul G.
name: Roca, Ignasi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Early detection of disseminating vancomycin-resistant Enterococcus faecium (VREfm) in ICU wards is crucial for outbreak identification and the implementation of prompt infection control measures. Genotypic methods like pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS) are costly and time-consuming, hindering rapid response due to batch dependency. Fourier-transform infrared spectroscopy (FT-IR) offers potential for real-time outbreak detection and reliable strain typing. We utilized FT-IR to identify clonal VREfm dissemination and compared its performance to PFGE and WGS. Between February through October 2023, an unusually high number of VREfm were recovered at a tertiary hospital in Barcelona. Isolates were examined for antimicrobial susceptibility, carriage of vanA/vanB genes and clonality was also studied using FT-IR, PFGE, and WGS. Routine FT-IR inspections revealed recurring VREfm clustering during the outbreak's initial weeks. In total, 104 isolates were recovered from 75 patients and from multiple wards. However, only one isolate was recovered from an environmental sample, suggesting the absence of environmental reservoirs. An ST80 vancomycin-resistant (vanA) E. faecium strain was the main strain responsible for the outbreak, although a few additional VREfm strains were also identified, all belonging to CC17. PFGE and cgMLST (WGS) yielded identical clustering results to FT-IR, and WGS confirmed vanA/vanB gene carriage in all VREfm isolates. Infection control measures led to a rapid decline in VREfm isolates, with no isolates detected in November. FT-IR spectroscopy offers rapid turnaround times, sensitivity, and reproducibility, comparable to standard typing methods. It proved as an effective tool for monitoring VREfm dissemination and early outbreak detection.
Checkpoint-mediated regulations of meiotic double-strand-break repair and crossover formation in Drosophila melanogaster
Creators: name: Joyce, Eric F.
Publisher: name: No Publisher Supplied
Year: 2010

description: During meiotic prophase, programmed DNA double-strand breaks (DSBs) are required to initiate recombination between homologous chromosomes and are repaired as either crossovers or noncrossovers. Crossovers provide a link between the homologs and facilitate their orientation on the meiosis I spindle and segregation at anaphase. Although studies in a variety of experiment systems have identified and characterized numerous factors necessary for crossover formation, far less is known about how the distribution and number of crossovers are controlled. The process of repairing meiotic DSBs is monitored by at least two surveillance mechanisms: the canonical DSB repair checkpoint that responds to DNA damage and another that requires the widely conserved AAA+ ATPase Pch2, hereafter referred to as the "pachytene checkpoint." In Saccharomyces cerevisiae and Caenorhabditis elegans, pachytene checkpoint activity has been detected with mutations in genes encoding structural proteins required for crossing over; however, it remains unclear what the underlying process is that the pachytene checkpoint is monitoring. I identified the Drosophila pachytene checkpoint by conducting a phenotypic analysis of different classes of recombination-defective mutants.  Specifically, the Drosophila pachytene checkpoint delays prophase progression when genes necessary for DSB repair and crossover formation are defective, but surprisingly functions independently of DSB formation. In addition, I investigated the relationship between chromosome structure and the pachytene checkpoint and found that defects in chromosome axis components also cause pch2-dependent delays. These findings suggest the pachytene checkpoint monitors two genetically distinct events: an early function of DSB repair proteins and the organization of chromosome axes. In support of this model, heterozygous chromosome aberrations result in a pachytene delay and interchromosomal increase in crossovers that are both dependent on pch2. My studies have led to a model where the sites and/or conditions required to promote crossovers are established independent of DSB formation early in meiotic prophase. The pachytene checkpoint may function to promote an optimal number of crossovers by regulating the duration of PCH2 expression, which defines the crossover determination phase. These results have provided new insights into this highly conserved surveillance mechanism as well as its relationship to pachytene progression and crossover control.
Sinocyclocheilus donglanensis Zhao, Watanabe & Zhang 2006
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Sinocyclocheilus
Sinocyclocheilus donglanensis

description: Sinocyclocheilus donglanensis Zhao, Watanabe & Zhang, 2006 (Fig. 34)
Holotype. 94746 (CA139), Tunyu Cave, Tunchang, Gongping Village, Taiping Town, Donglan County, Guangxi Province, P. R. China, Oct. 7, 2002.
Paratypes. 74217-74218, 94747-94748 (CA141, CA143), collected with holotype.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 43, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Out of the blue: detection of a unique highly pathogenic avian influenza virus of subtype H7N5 in Germany
Creators: name: Ahrens, Ann Kathrin
name: Pohlmann, Anne
name: Grund, Christian
name: Beer, Martin
name: Harder, Timm C.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Out of the blue: detection of a unique highly pathogenic avian influenza virus of subtype H7N5 in Germany
Additional file 4: of Effectiveness of real-time polymerase chain reaction assay for the detection of Mycobacterium tuberculosis in pathological samples: a systematic review and meta-analysis
Creators: name: Babafemi, Emmanuel
name: Cherian, Benny
name: Banting, Lee
name: Mills, Graham
name: Kandala Ngianga
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Definition of statistical parameters. (DOC 39 kb)
MOESM10 of Infection of a tomato cell culture by Phytophthora infestans; a versatile tool to study Phytophthora-host interactions
Creators: name: Schoina, Charikleia
name: Bouwmeester, Klaas
name: Govers, Francine
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology
subject: 60506 Virology

description: Additional file 10: Table S4. qRT-PCR primers used in this study.
Disputed relocation and property development in Shanghai, 1990-2005
Creators: name: Shih, Mi
Publisher: name: No Publisher Supplied
Year: 2010

description: This dissertation research examines social conflicts over large-scale community displacement arising from capitalist property development beginning in the early 1990s in Shanghai, China. Using ethnographic, archival, and legal research methods, this research provides an in-depth analysis of residents' years-long opposition to forced relocation, through which they sought to assert claims of rights and interests in the context of China's still top-down property regime. It argues that two structural forces prevent a broader participatory movement from raising a fundamental challenge to the existing property development regime: the design and application of relocation law, and the state's power to exploit residents' fears of being accused as political subversives if they challenge the relocation process. These material and ideological forces act together to deflect residents' collective attempts to challenge the existing property regime and, instead, to channel opposition into a discussion of personal (i.e., individual) economic loss and its remediation through pecuniary compensation. This dissertation also examines how law and state supremacy serve to deter and deflect conflicts by providing a source of legitimation for the developmental forces driving disputed relocation. The research advances understanding of how urban China's spatial modernization policy has turned into a source of social unrest, which in turn has enhanced the development of a civil and rights-conscious society in China.
Xystonotus Wolcott 1900
Creators: name: Pešić, Vladimir
name: Cook, David
name: Gerecke, Reinhard
name: Smit, Harry
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Mideopsidae
Xystonotus

description: Genus Xystonotus Wolcott, 1900
description: Published as part of Pešić, Vladimir, Cook, David, Gerecke, Reinhard & Smit, Harry, 2013, The water mite family Mideopsidae (Acari: Hydrachnidia): a contribution to the diversity in the Afrotropical region and taxonomic changes above species level, pp. 1-75 in Zootaxa 3720 (1) on page 69, DOI: 10.11646/zootaxa.3720.1.1, http://zenodo.org/record/285029
Multi-objective stochastic models for electricity generation expansion planning problems considering risk
Creators: name: Tekiner, Hatice
Publisher: name: No Publisher Supplied
Year: 2010

description: This dissertation is focused on the development of mathematical models to solve electricity generation expansion planning problems where important problem objectives, such as cost, greenhouse gas and pollutant emissions and reliability are explicitly considered under an uncertain environment.  Generation expansion planning problems are solved to determine what, when and where to built the new technologies.  The main objective of the power grid is to provide an economic and reliable energy supply to consumers.  Due to the increasing awareness for clean air and global warming, the power grid should also be designed to be environmental friendly.  In this research, an approach is proposed to determine critical components for the grid with regard to reliability, cost and gas emissions, and an optimization approach is proposed to select a set of availability scenarios which represent the stochastic characteristics of the system and to determine the associated probabilities.  The problem is formulated as a two stage multi-objective stochastic optimization problem considering the generated scenarios. There are also some other technological developments, called "Smart Grid Technologies" which can affect the grid.  The impacts of "Smart Grid Technologies" on the grid are that (i) shift/reduce energy demand, (ii) increase the effective availability of the system components, and (iii) reduce the energy loss during transmission.  This research is the first comprehensive attempt to include the Smart Grid technologies, affecting the availabilities and transmission loss, into the generation expansion planning problem.  This research also leads to the contributions for developing models where risk aversion is incorporated into the model, improving solution efficiency by extending Benders decomposition and improving solution techniques for multi-objective optimization problems.
Transmission of blaNDM in Enterobacteriaceae among animals, food and human
Creators: name: Fu, Bo
name: Xu, Jian
name: Yin, Dandan
name: Sun, Chengtao
name: Liu, Dejun
name: Zhai, Weishuai
name: Bai, Rina
name: Cao, Yue
name: Zhang, Qin
name: Ma, Shizhen
name: Walsh, Timothy R.
name: Hu, Fupin
name: Wang, Yang
name: Wu, Congming
name: Shen, Jianzhong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Despite carbapenems not being used in animal, Carbapenem-Resistant-Enterobacterales (CRE), particularly New-Delhi-metallo-β-lactamase-producing-CRE (NDM-CRE), are prevalent in livestock. Concurrently, the incidence of human infections caused by NDM-CRE is rising, particularly in children. Although positive association between livestock production and human NDM-CRE infections at national level was identified, the evidence of direct transmission of NDM originating from livestock to humans remains largely unknown. Here we conducted a cross-sectional study in Chengdu, Sichuan Province to examine the prevalence of NDM-CRE in chickens and pigs along the breeding-slaughtering-retail chains, in pork in cafeterias of schools, and in colonisations and infections from a children's hospital, and examined the correlation of NDM-CRE among animals, foods and humans. Overall, the blaNDM increases gradually along the chicken and pig breeding (4.70%/2.0%) - slaughtering (7.60%/22.40%) - retail (65.56%/34.26%) chains. The slaughterhouse has become a hotspot for cross-contamination and amplifier of blaNDM. Notably, 63.11% pork from school cafeteria were positive for blaNDM. The prevalence of blaNDM in intestinal and infection samples from children's hospital was 21.68% and 19.80%, respectively. WGS analysis revealed the sporadic, not large-scale, clonal spread of NDM-CRE along the chicken and pig breeding-slaughtering-retail chain, with further spreading via IncX3-blaNDM plasmid within each stage of whole chains. Whist clonal transmission of NDM-CRE is predominant in children's hospital. The IncX3-blaNDM plasmid was highly prevalent among animals and humans and accounted for 57.7% in Escherichia coli and 91.3% in Klebsiella pneumoniae. Attention should be directed towards the IncX3 plasmid to control the transmission of blaNDM between animals and humans.
Additional file 2 of McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes
Creators: name: Hafez, Dina
name: Aslihan Karabacak
name: Krueger, Sabrina
name: Yih-Chii Hwang
name: Li-San Wang
name: Zinzen, Robert
name: Ohler, Uwe
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Computational Biology

description: Materials and methods supplement. This text explains McEnhancer in more details; phase I and II of McEnhancer, model selection parameters and cross validation. (PDF 236 kb)
Sinocyclocheilus guilinensis Zhao, Zhang & Zhou 2009
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Sinocyclocheilus
Sinocyclocheilus guilinensis

description: Sinocyclocheilus guilinensis Zhao, Zhang & Zhou, 2009 (Fig. 36)
Holotype. 113753 (82376), Guilin City, Guangxi Province, P. R. China, 1982. Paratype. 113754 (82377), collected with holotype.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 46, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Increasing women's aspirations and achievement in science
Creators: name: Phelan, Julie E.
Publisher: name: No Publisher Supplied
Year: 2010

description: This research investigated the role of implicit science beliefs in the gender gap in science aspirations and achievement, with the goal of testing identification with a female role model as a potential intervention strategy for increasing women's representation in science careers.  At Time 1, women's implicit science stereotyping (i.e., associating men more than women with science) was linked to more negative (implicit and explicit) attitudes towards science and less identification with science. For men, stereotypes were either non-significantly or positively related to science attitudes and identification. Time 2 examined the influence of implicit and explicit science cognitions on students' science aspirations and achievement, and found that implicit stereotyping, attitudes, and identification were all unique predictors of science aspirations, but not achievement. Of more importance, Time 2 examined the influence of science role models, and found that identification with a role model of either gender reduced women's implicit science stereotyping and increased their positive attitudes toward science.  Implications for decreasing the gender gap in advanced science achievement are discussed.
Amblyseius adhatodae Muma 1967
Creators: name: KamranK, Muhammad
name: AlatawiK, Fahad Jaber
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Phytoseiidae
Amblyseius
Amblyseius adhatodae

description: Amblyseius adhatodae Muma (Figures 5–6)
Amblyseius adhatodae Muma, 1967: 268 ; Moraes et al. 1989 b: 79; Chant and McMurtry 2004: 203 ; Moraes et al. 2004: 12 ; Gupta 1985: 336 ; Döker et al. 2022: 866.
description: Published as part of KamranK, Muhammad & AlatawiK, Fahad Jaber, 2024, Complementary description of three Amblyseius species (Acari: Mesostigmata ; Phytoseiidae) and keys to the world species of duncansoni and largoensis species subgroups, pp. 925-940 in Acarologia 64 (3) on page 931, DOI: 10.24349/hr32-1gg9, http://zenodo.org/record/14670336
Disulfide-stabilized Trimeric Hemagglutinin Ectodomains Provide Enhanced Heterologous Influenza Protection
Creators: name: Liu, De-Jian
name: Zhong, Xiu-Qin
name: Ru, Yan-Xia
name: Zhao, Shi-Long
name: Liu, Cui-Cui
name: Tang, Yi-Bo
name: Wu, Xuan
name: Zhang, Yi-Shuai
name: Zhang, Hui-Hui
name: She, Jia-Yue
name: Wan, Mu-Yang
name: Li, Yao-Wang
name: Zheng, He-Ping
name: Deng, Lei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Influenza virus infection poses a continual menace to public health. Here, we developed soluble trimeric HA ectodomain vaccines by establishing interprotomer disulfide bonds in the stem region, which effectively preserve the native antigenicity of stem epitopes. The stable trimeric H1 ectodomain proteins exhibited higher thermal stabilities in comparison with unmodified HAs and showed strong binding activities towards a panel of anti-stem cross-reactive antibodies that recognize either interprotomer or intraprotomer epitopes. Negative stain transmission electron microscopy (TEM) analysis revealed the stable trimer architecture of the interprotomer disulfide-stapled WA11#5, NC99#2, and FLD#1 proteins as well as the irregular aggregation of unmodified HA molecules. Immunizations of mice with those trimeric HA ectodomain vaccines formulated with incomplete Freund’s adjuvant elicited significantly more potent cross-neutralizing antibody responses and offered broader immuno-protection against lethal infections with heterologous influenza strains compared to unmodified HA proteins. Additionally, the findings of our study indicate that elevated levels of HA stem-specific antibody responses correlate with strengthened cross-protections. Our design strategy has proven effective in trimerizing HA ectodomains derived from both influenza A and B viruses, thereby providing a valuable reference for designing future influenza HA immunogens.
MOESM10 of Infection of a tomato cell culture by Phytophthora infestans; a versatile tool to study Phytophthora-host interactions
Creators: name: Schoina, Charikleia
name: Bouwmeester, Klaas
name: Govers, Francine
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology
subject: Virology

description: Additional file 10: Table S4. qRT-PCR primers used in this study.
Contract human capital human resource architecture
Creators: name: Castellano, William G.
Publisher: name: No Publisher Supplied
Year: 2010

description: As contract human capital continues to grow and become a powerful force in the economy contributing to the success of many organizations, it is vital for researchers to enhance their understanding of how organizations engage and manage this component of their workforce. Equally important, is to assess how individuals respond to and perform in a rapidly changing and flexible workplace. Indeed, the major findings of this study provide many helpful insights for understanding and managing this increasingly important segment of the labor force. While much of SHRM research has enhanced our understanding of how organizations differentiate managing their "traditional" workforce, this study enhances our understanding of how organizations differentiate  managing contract human capital based on the interdependency and criticality of the work. In support of contingency theory, the findings also demonstrate that the strategic reasons for engaging contract human capital impact the choice of HR configuration for managing them. A key strategic moderator is organizational flexibility. It seems organizations seeking functional flexibility do so by investing more in the employment relationship, whereas, those seeking coordination flexibility do so by investing less in the employment relationship. The findings of this study also shed more light on the determinants and relationship of contract human capital's perceptions of fairness (POF) and psychological contract breach (PCB). Though there is a large body of research that supports POF moderating the relationship between HR configurations and PCB, this study found support for POF mediating the relationship. Furthermore, it seems that some contract human capital who enter into these work arrangements to earn more money or develop a skill consider these as valuable outputs to be included in equity comparisons (Adams, 1965; Morrison & Robinson, 1997) when assessing fairness, whereas those whose work preference was flexibility or obtaining permanent employment consider these as promises to be evaluated when assessing psychological contract fulfillment. Lastly, the results show how contract human capital are managed matters to both the individual and the work group. Alignment of the type of work performed and HR configurations were significantly related to individual task performance and organizational citizenship behaviors.
Infernal retainers
Creators: name: Valterza, Loren Michael
Publisher: name: No Publisher Supplied
Year: 2010

description: This dissertation examines the doctrinal relationship between Dante and contemporary legal scholars, particularly Cino da Pistoia. The study positions Dante's work within ongoing debates between French (Orleanese) and Italian (Bolognese) jurists at the turn of the fourteenth century, arguing that Dante's representations of positive law and its practitioners arise out of his longstanding engagement with the Justinian Corpus.
DownscaleBench: A benchmark dataset for statisticaldownscaling of meteorological fields
Creators: name: Langguth, Michael
name: Lehner, Sebastian
name: Harder, Paula
name: Patnala, Ankit
name: Schicker, Irene
name: Dabernig, Markus
name: Schultz, Martin
Publisher: name: Forschungzentrum Jülich
Year: 2024

description: Workshop on Large-Scale Deep Learning for the Earth System, LSDL4ES 2024, Bonn, Germany, 29 Aug 2024 - 30 Aug 2024
description: Statistical downscaling with deep neural networks has recently gained a lot of momentum in the meteorological community. While several studies show promising results, direct comparison between different approaches is often impeded due to a large variety in the related downscaling task (target quantity), the deployed dataset and the evaluation framework. Furthermore, the performance of deep neural networks for statistical downscaling is barely compared to classical downscaling methods that have been established in the meteorological domain over the last decades. To enable fair comparison between different downscaling techniques, we suggest DownscaleBench, a benchmark dataset based on the coarse-grained ERA5 and the high-resolved COSMO REA6-dataset. DownscaleBench provides a standardized set of predictors for three (deterministic) downscaling tasks, that are downscaling of 2m temperature, 100m wind and solar irradiance. The ready-to-use datasets are complemented by a set of baseline models (standard deep neural networks and a classical method) whose performance is accessed in a task-specific, but standardized evaluation framework.
Sinocyclocheilus flexuosdorsalis Zhu & Zhu 2012
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Sinocyclocheilus
Sinocyclocheilus flexuosdorsalis

description: Sinocyclocheilus flexuosdorsalis Zhu & Zhu, 2012 (Fig. 35)
Holotype. 199011 (2011001), karst cave, Shengqiao Town, Longlin County, Guangxi Province, P. R. China, Jul., 2011. Paratype. 199012 (2011002), collected with holotype.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 44, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine
Creators: name: Yisimayi, Ayijiang
name: Song, Weiliang
name: Wang, Jing
name: Jian, Fanchong
name: Yu, Yuanling
name: Chen, Xiaosu
name: Xu, Yanli
name: An, Ran
name: Wang, Yao
name: Sun, Haiyan
name: Wang, Peng
name: Yu, Lingling
name: Shao, Fei
name: Jin, Ronghua
name: Shen, Zhongyang
name: Wang, Youchun
name: Cao, Yunlong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRNA vaccines, a disparity yet to be understood. Here, we analyzed the immune imprinting alleviation in inactivated vaccine (CoronaVac) cohorts after a long-term period following breakthrough infections (BTI). We observed in CoronaVac-vaccinated individuals who experienced BA.5/BF.7 BTI, the proportion of Omicron-specific memory B cells (MBCs) substantially increased after an extended period post-Omicron BTI, with their antibodies displaying enhanced somatic hypermutation and neutralizing potency. Consequently, the neutralizing antibody epitope distribution encoded by MBCs post-BA.5/BF.7 BTI after prolonged maturation closely mirrors that in BA.5/BF.7-infected unvaccinated individuals. Together, these results indicate the activation and expansion of Omicron-specific naïve B cells generated by first-time Omicron exposure helped to alleviate CoronaVac-induced immune imprinting, and the absence of this process should have caused the persistent immune imprinting seen in mRNA vaccine recipients.
Climate change and its ecological and socioeconomic impact
Creators: name: Wang, Yufei
Publisher: name: No Publisher Supplied
Year: 2010

description: Climate change is currently of great concern by scientist and public. However, the  ecological and socio-economic effects of long-term climate change remains largely  unknown. To study on the long-term climate change, and its impacts on the environmental  conditions, ecological and socio-economic consequences, the long time series of climate  related events from historical records are needed to fill the gap of the instrumental data. In  this study, a unique data source -- "The compendium of Chinese Meteorological records of  the Last 3,000 years (Zhang 2004) which contains invaluable information about climate  related events recorded in the China's historical documents were digitized for the last  Dynasty.  Pearson correlation test was conducted to test the relationship between crop harvest  and climate events in case study one. The results revealed that climate conditions affected  past agriculture harvest in China. Besides direct effect of cooling on the land carrying  capacity, periodic ecological stresses such as drought events can significantly reduce the  agricultural yield. The issue of stationarity of variables is the great concern in this study.  Local variations both in temporal and spatial scale analysis were considered in the  following case studies. Second case study applied continuous wavelet analysis for  analyzing the local variation in temporal scale. The result revealed that the periodicity of  fluctuations of locusts, temperature and drought series are consistently at around 100  year's band. The consistent associations between locust and temperature, temperature and  drought, locust and drought at same frequency and time space indicted the possible casual  interlinks of temperature-drought-locust plague. The finding suggests that drought events  driven by long term variation of temperature change explains locust dynamics better than  floods.  The last case study used Geographically Weighted Regression methods for  analyzing spatially varying relationships between determinate variable--famine and  explanatory variables such as floods, droughts, poor harvest and locust outbreaks. The  results implicated that all variables have significant effects on famine occurrence in last  Dynasty of China. Among the explanatory variables, drought shows strongest effect on  famine. The results also suggested that there are significant spatial variations across the  study area. Therefore, it's important to consider the local regression methods for analyzing  the relationships between famine and other climate conditions.
Sinocyclocheilus huangtianensis Zhu, Zhu & Lan 2011
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Sinocyclocheilus
Sinocyclocheilus huangtianensis

description: Sinocyclocheilus huangtianensis Zhu, Zhu & Lan, 2011 (Fig. 37)
Holotype. 200110 (2010003), Youmayan Viilage, Huangtian Town, Hezhou City, Guangxi Province, P. R. China, Jun., 2010. Paratypes. 200111 - 200115, collected with holotype.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 46, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Worker Protection Standard (WPS) Factsheet # 1: Organophosphates
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection (NJDEP) Pesticide Control Program (PCP)
Year: 1999

description: The New Jersey Department of Environmental Protection (NJDEP) Pesticide Control Program's Worker Protection Standard (WPS) Unit publishes fact sheets on various pesticides that are distributed to agricultural employers to have on file should their employees request them.  This is one component of the WPS program to inform agricultural workers of the pesticides to which they are exposed and the possible effects of the chemicals on their health.  This factsheet (#1 in the series) covers Organophosphates, containing information such as its chemical and common names, symptoms of poisoning, short- and long-term health hazards, protective equipment that should be worn when working with the pesticide and emergency treatment.
Mercury in the Environment
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 2001

description: This report is an update of the 1998 report.  It describes mercury and its effect on the environment. The report includes general information about the health effects and risks of  exposure to mercury.  Details are provided about state and federal regulations and protection against mercury.  There is also a list of phone numbers for well owners.
Imperiled Shorebirds on Delaware Bay: What You Can Do to Help
Creators: name: No Name Supplied
Publisher: name: Endangered and Nongames Species Program, New Jersey Department of Environmental Protection (NJDEP)
Year: 2003

description: This pamphlet highlights the dangers to New Jersey's shorebirds as a result of a decline crab eggs, the birds' food. The pamphlet suggests ways to help protect the shorebirds environment.
Out of the blue: Detection of a unique highly pathogenic avian influenza virus of subtype H7N5 in Germany.
Creators: name: Ahrens, Ann Kathrin
name: Pohlmann, Anne
name: Grund, Christian
name: Beer, Martin
name: Harder, Timm C.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Out of the blue: Detection of a unique highly pathogenic avian influenza virus of subtype H7N5 in Germany.
Ocean Resources Management in New Jersey
Creators: name: No Name Supplied
Publisher: name: Office of Coastal Planning, New Jersey Department of Environmental Protection (NJDEP)
Year: 2002

description: As part of its Section 309 Coastal Zone Enhancement Strategy, the New Jersey Department of Environmental Protection, Office of Coastal Planning, began an in-depth process to develop an Ocean Resources Management Plan. This fact sheet describes the importance of ocean resources and the future of the Ocean Resources Management Plan.
Filtration Testing for Arsenic Removal from Groundwater by TiO2 Adsorption Media: Final Report
Creators: name: No Name Supplied
Publisher: name: Division of Science, Research and Technology of the New Jersey Department of Environmental Protection
Year: 2003

description: Laboratory and field experiments were conducted to study the effectiveness of a novel titanium dioxide (TiO2) adsorbent and four commercial adsorption media for removal of arsenic.  The commercial media included granular ferric hydroxide (GFH), activated alumina (AA), modified AA, and granular ferric oxide (GFO).  Laboratory experiments were also carried out to investigate arsenic removal from challenge water.
Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus
Creators: name: Ren, Zuning
name: Li, Mengjun
name: Chen, Jiayin
name: Gong, Xiaohua
name: Song, Shuo
name: li, Delin
name: Yang, Minghui
name: Yu, Jianhai
name: Asghar, Sadia
name: Cui, Yanxin
name: Niu, Shiyu
name: Liao, Zhonghui
name: Jiang, Yushan
name: Liu, Jiahui
name: Li, Yuqing
name: Zhang, Bao
name: Zhao, Wei
name: Peng, Jie
name: Yang, Yang
name: Shen, Chenguang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions. Passive immunotherapy, such as the use of monoclonal antibodies (mAbs) and bispecific antibodies (bsAbs), has emerged as a promising option for antiviral regimens. Here, we generated several mAbs against M1R and B6R of MPXV, and subsequently characterized the antiviral activity of these antibodies both in vitro and in vivo. Two neutralizing mAbs, M1H11 and M3B2, targeting M1R, and one B6R-specific mAb, B7C9, were identified. They exhibited varying antiviral efficacy against MPXV and vaccinia virus (VACV) in vitro and orthopoxvirus infection in vivo. A cocktail comprising M1H11 and M3B2 demonstrated a superior protective effect in vivo. A bsAb, Bis-M1M3, was engineered by conjugating the fragment crystallizable (Fc) region of the human-mouse chimeric engineered M1H11 with the single-chain fragment variable (scFv) of M3B2. In mice challenged with MPXV, Bis-M1M3 showed a notable protective effects, including the absence of mortality. Analysis of neutralization mechanism showed that these mAbs and Bis-M1M3 exerted virus-neutralizing effects before the virus infects cells. In vivo pharmacokinetic experiments showed that Bis-M1M3 has a long half-life in rhesus macaques. This study provides crucial insights for further research on -broad-spectrum antiviral drugs against MPXV and other orthopoxviruses.
Prolonged Omicron-Specific B Cell Maturation Alleviates Immune Imprinting Induced by SARS-CoV-2 Inactivated Vaccine
Creators: name: Yisimayi, Ayijiang
name: Song, Weiliang
name: Wang, Jing
name: Jian, Fanchong
name: Yu, Yuanling
name: Chen, Xiaosu
name: Xu, Yanli
name: An, Ran
name: Wang, Yao
name: Sun, Haiyan
name: Wang, Peng
name: Yu, Lingling
name: Shao, Fei
name: Jin, Ronghua
name: Shen, Zhongyang
name: Wang, Youchun
name: Cao, Yunlong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRNA vaccines, a disparity yet to be understood. Here, we analyzed the immune imprinting alleviation in inactivated vaccine (CoronaVac) cohorts after a long-term period following breakthrough infections (BTI). We observed in CoronaVac-vaccinated individuals who experienced BA.5/BF.7 BTI, the proportion of Omicron-specific memory B cells (MBCs) substantially increased after an extended period post-Omicron BTI, with their antibodies displaying enhanced somatic hypermutation and neutralizing potency. Consequently, the neutralizing antibody epitope distribution encoded by MBCs post-BA.5/BF.7 BTI after prolonged maturation closely mirrors that in BA.5/BF.7-infected unvaccinated individuals. Together, these results indicate the activation and expansion of Omicron-specific naïve B cells generated by first-time Omicron exposure helped to alleviate CoronaVac-induced immune imprinting, and the absence of this process should have caused the persistent immune imprinting seen in mRNA vaccine recipients.
Cardiac dynamics of a human ventricular tissue model with focus on early afterdepolarizations
Creators: name: Erhardt, André
Publisher: name: Weierstrass Institute
Year: 2024
Subjects: subject: Cardiac dynamics
subject: bifurcations analysis
subject: early afterdepolarization
subject: monodomain equation
subject: pattern formation
subject: 92B25
subject: 92C05
subject: 37G15;37M05;
subject: 37N25

description: The paper is aimed to investigate computationally complex cardiac dynamics of the famous human ventricular model of ten Tusscher and Panfilov from 2006. The corresponding physical system is modeled by a set of nonlinear differential equations containing various of system pa- rameters. In case a specific physical parameter crosses a certain threshold, the system is forced to change dynamics, which might result in dangerous cardiac dynamics and can be precursors to cardiac death. For the performance of an efficient numerical analysis the original model is remod- eled and simplified in such a way that the modified models perfectly matches the trajectory of the original model. Moreover, it is demonstrated that the simplified models have the same dynamics. Furthermore, using the lowest dimensional model it is systematically shown by means of bifur- cation analysis that combinations of reduced slow and rapid potassium channels and enhanced sodium channel may lead to early afterdepolarizations. Finally, synchronization and the effect of EADs on larger scale (macro scale) is investigated numerically by studying the corresponding monodomain model. To this end we study the pattern formation of an one dimensional network of epi-, mid-myo- and endocardial cells and a two dimensional epicardial monodomain equation.
Bispecific antibodies provide broad neutralization of emerging beta-coronaviruses by targeting ACE2 and viral spikes
Creators: name: Li, Minghui
name: Zhao, Chaoyue
name: Shi, Jialu
name: Wang, Xun
name: Liu, Yuanchen
name: Zhao, Xiaoyu
name: Cai, Guonan
name: Chu, Hin
name: Wang, Pengfei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Human coronaviruses such as SARS-CoV, MERS-CoV, and SARS-CoV-2 have recurrently emerged as significant pathogens, causing severe respiratory illnesses and presenting challenges to monoclonal antibody therapeutics due to their rapid evolution, particularly the diverse variants of SARS-CoV-2. In this study, we utilized “Knob-into-Hole” and “IgG-scFv” technologies to engineer bispecific antibodies (bsAbs) that target both the viral receptor and spike protein, enhancing their neutralization breadth and potency. Our bsAbs, combining anti-SARS-CoV-2 or anti-MERS-CoV antibodies with an anti-ACE2 antibody, demonstrated effective neutralization across a range of SARS-CoV-2 variants, SARS-CoV and MERS-CoV in both pseudovirus and authentic virus assays. Notably, the “IgG-scFv” bsAbs format exhibited superior binding and neutralization capabilities compared to the “Knob-into-Hole” configurations. The most effective of these, “IgG-scFv” H11B11_m336, displayed exceptional neutralization potency against a panel of 24 pseudotyped Beta-Coronaviruses, with IC50 values ranging from 0.001–0.183 μg/mL. Overall, our findings underscore the potential of bsAbs as an effective strategy to meet the immediate challenges posed by existing and emerging pathogens, thereby enhancing global pandemic preparedness.