cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Caritas Dashboard: Prototype Insights, Dokumentation und Reporting
Creators: name: Glaus, Jeremy
name: Sutter, Rulla
name: Hümbelin, Oliver
Publisher: name: Berner Fachhochschule, Soziale Arbeit
Year: 2025

description: The counseling centers Social Welfare NGOs, such as Caritas, support people affected by poverty. In the course of these interactions, data is generated that has so far been scarcely used systematically. At the same time, there is great potential to make a significant contribution to more effective support processes through systematic data usage. A technically functional dashboard prototype illustrating the various activities within the Caritas Switzerland network can help spark discussions about how data from client interactions might be evaluated and used in day-to-day operations—both by Caritas Switzerland and especially by regional offices like Caritas Basel. A research team from the NRP 80 project of the Swiss National Science Foundation, supported by an “Innovation Cheque” (from Innosuisse – the Swiss Innovation Agency) and through participation in “Hack4Social Good 2024,” developed such a prototype. This design was further refined during a sprint in December 2024. Using this prototype, the opportunities and challenges of targeted data usage by Caritas can be highlighted—laying the foundation for further discussions on systematic data utilization.
title: DOC KEY NOTE LECTURE
Creators: name: Porzsolt, Franz
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Seit es die Evidenzbasierte Medizin gibt, ist die Randomisation die Ursache heftiger Diskussionen. Die Evidenzbasierte Medizin 2017 bietet dazu Lösungen an. Sie erklärt die Bedeutung der Effekte von efficacy und effectiveness. Erstere bestätigt, dass eine Intervention unter Ideal Study[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
title: Endothelzellverlust bei Kataraktchirurgie: Ist FLACS wirklich besser als Phaco-Chop?
Creators: name: Kleineberg, Lea
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Ziel: Vergleich zwischen FLACS und Phaco-Chop betreffend Endothelzellverlust    Methode: Wir haben retrospektiv 40 Patienten aus unserem Patientenkollektiv untersucht. 20 Patienten wurden mit der FLACS-Methode (LenSx, Fa. Alcon), 20 Patienten mit der Phaco-Chop-Methode (PentaSys, Fa. Ruck) operiert.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
Additional file 1 of Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Creators: name: Cui, Pin
name: Zhou, Xiaozhou
name: Xu, Shu
name: He, Weihuang
name: Huang, Guozeng
name: Xiong, Yong
name: Zhang, Chuxin
name: Chang, Tingmin
name: Feng, Mingji
name: Lai, Hanming
name: Pan, Yi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Figure S1. The GO directed acyclic graphs for the unique biomarker genes of HCC group.
Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development
Creators: name: Yilmazer, Acelya
name: Zevla, Dimitra Maria
name: Malmkvist, Rikke
name: Rodríguez, Carlos Alejandro Bello
name: Undurraga, Pablo
name: Kirgin, Emre
name: Boernert, Marie
name: Voehringer, David
name: Kershaw, Olivia
name: Schlenner, Susan
name: Kretschmer, Karsten
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: immune tolerance
subject: autoimmunity
subject: scurfy
subject: diabetes
subject: T cell development
subject: pTreg
subject: tTreg
subject: Foxp3
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Foxp3+ regulatory T (Treg) cells of thymic (tTreg) and peripheral (pTreg) developmental origin are thought to synergistically act to ensure immune homeostasis, with self-reactive tTreg cells primarily constraining autoimmune responses. Here we exploited a Foxp3-dependent reporter with thymus-specific GFP/Cre activity to selectively ablate either tTreg (ΔtTreg) or pTreg (ΔpTreg) cell development, while sparing the respective sister populations. We found that, in contrast to the tTreg cell behavior in ΔpTreg mice, pTreg cells acquired a highly activated suppressor phenotype and replenished the Treg cell pool of ΔtTreg mice on a non-autoimmune C57BL/6 background. Despite the absence of tTreg cells, pTreg cells prevented early mortality and fatal autoimmunity commonly observed in Foxp3-deficient models of complete Treg cell deficiency, and largely maintained immune tolerance even as the ΔtTreg mice aged. However, only two generations of backcrossing to the autoimmune-prone non-obese diabetic (NOD) background were sufficient to cause severe disease lethality associated with different, partially overlapping patterns of organ-specific autoimmunity. This included a particularly severe form of autoimmune diabetes characterized by an early onset and abrogation of the sex bias usually observed in the NOD mouse model of human type 1 diabetes. Genetic association studies further allowed us to define a small set of autoimmune risk loci sufficient to promote β cell autoimmunity, including genes known to impinge on Treg cell biology. Overall, these studies show an unexpectedly high functional adaptability of pTreg cells, emphasizing their important role as mediators of bystander effects to ensure self-tolerance.
Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters
Creators: name: Teixeira Alves, Luiz Gustavo
name: Baumgardt, Morris
name: Langner, Christine
name: Fischer, Mara
name: Maria Adler, Julia
name: Bushe, Judith
name: Firsching, Theresa Catharina
name: Mastrobuoni, Guido
name: Grobe, Jenny
name: Hoenzke, Katja
name: Kempa, Stefan
name: Gruber, Achim Dieter
name: Hocke, Andreas Christian
name: Trimpert, Jakob
name: Wyler, Emanuel
name: Landthaler, Markus
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: respiratory infection
subject: pneumonia
subject: inflammation
subject: COVID-19
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Introduction The emergence of new SARS-CoV-2 variants, capable of escaping the humoral immunity acquired by the available vaccines, together with waning immunity and vaccine hesitancy, challenges the efficacy of the vaccination strategy in fighting COVID-19. Improved therapeutic strategies are urgently needed to better intervene particularly in severe cases of the disease. They should aim at controlling the hyperinflammatory state generated on infection, reducing lung tissue pathology and inhibiting viral replication. Previous research has pointed to a possible role for the chaperone HSP90 in SARS-CoV-2 replication and COVID-19 pathogenesis. Pharmacological intervention through HSP90 inhibitors was shown to be beneficial in the treatment of inflammatory diseases, infections and reducing replication of diverse viruses. Methods In this study, we investigated the effects of the potent HSP90 inhibitor Ganetespib (STA-9090) in vitro on alveolar epithelial cells and alveolar macrophages to characterise its effects on cell activation and viral replication. Additionally, the Syrian hamster animal model was used to evaluate its efficacy in controlling systemic inflammation and viral burden after infection. Results In vitro, STA-9090 reduced viral replication on alveolar epithelial cells in a dose-dependent manner and lowered significantly the expression of proinflammatory genes, in both alveolar epithelial cells and alveolar macrophages. In vivo, although no reduction in viral load was observed, administration of STA-9090 led to an overall improvement of the clinical condition of infected animals, with reduced oedema formation and lung tissue pathology. Conclusion Altogether, we show that HSP90 inhibition could serve as a potential treatment option for moderate and severe cases of COVID-19.
KI-gestützte Protokollführung in der Sozialberatung
Creators: name: Sutter, Rulla
name: Hümbelin, Oliver
name: Bitumba-Bousfield, Marie-Paule
name: Witzthum, Harry
Year: 2025

description: Mehr als jede 6 Person ist in der Schweiz von Armut bedroht (15.6%). Doch ist die Dunkelziffer noch höher, da Armut in unserer Gesellschaft tabuisiert wird. Für Nonprofit-Organisationen wie die Caritas sind deshalb Angebote wie Sozial- und Schuldenberatung von zentraler Bedeutung, da sie konkrete Unterstützung für armutsbetroffene Menschen bieten. Im gegenwärtigen Umfeld von Spardruck auf öffentliche Mittel, Inflation, gestiegene Lebenshaltungskosten etc. sehen sich auch die Beratungsangebote ebenfalls grossem Effizienzdruck. Jede Stunde, die direkt in die Unterstützung von Klientinnen einfliesst, ist von Bedeutung. Es braucht innovative Ansätze zur Effizienzgewinnung.
title: Intraoperative Aberrometrie und Asphärizität von Intraokularlinsen – Vergleich verschiedener Intraokularlinsen aus der gleichen Plattform
Creators: name: Tandogan, Tamer
name: Cantagalli, Andrea
name: Tetz, Manfred
name: Khoramnia, Ramin
name: Auffarth, Gerd Uwe
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Vergleich der intraoperativen Aberrometrie an pseudophaken Augen mit der postoperativen Refraktion. Im Rahmen von Messungen der Abbott Tecnis® Intraokularlinsen (Ar40e®, AAB00®, ZCB00®, ZCT00® und ZMB00®) wurden Faktoren ermittelt, um systematische Abweichungen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
Hidden sodium in effervescent-tablet dietary supplements and over-the-counter drugs: a comparative cross-sectional study
Creators: name: Kunz, Michael
name: Götzinger, Felix
name: Jacobs, Cathy M
name: Lauder, Lucas
name: Ukena, Christian
name: Meyer, Markus R
name: Laufs, Ulrich
name: Schulz, Martin
name: Böhm, Michael
name: Mahfoud, Felix
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: hypertension
subject: heart failure
subject: cardiology
subject: preventive medicine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Objective Dietary sodium intake represents a risk factor for cardiovascular disease and mortality. The study sought to analyse the sodium content of effervescent dietary supplements and drugs in Germany and the USA. Design Comparative cross-sectional study. Setting and methods The sodium content of 39 dietary supplement effervescent tablets available in Germany was measured in May and June 2022 using optical emission spectrometry with inductively coupled argon plasma. The sodium content of 33 common pharmacy-only effervescent tablets (over-the-counter (OTC) drugs) in Germany was obtained from the summary of product characteristics. We compared the sodium content of the measured German dietary supplement effervescent tablets to that of 51 dietary supplement effervescent tablets available in the USA (data: National Institutes of Health’s Dietary Supplement Label Database). Results The measured sodium content in the German dietary supplements was 283.9±122.6 mg sodium/tablet, equivalent to 14±6% of the maximum recommended daily sodium intake (MRDSI). Vitamin products had the highest (378.3±112.8 mg, 19±6% of MRDSI), and calcium products had the lowest mean sodium content (170.4±113.2 mg, 9±6% of MRDSI). Vitamin products contained significantly more sodium than magnesium (378.3 mg vs 232.7 mg; p=0.004), calcium (378.3 mg vs 170.4 mg; p=0.006) and mineral products (378.3 mg vs 191.6 mg; p=0.048). The sodium content measured in products available in Germany was higher when compared with the declared sodium content on the label of the products sold in the USA (283.9 mg vs 190.0 mg; p<0.001). The median summary of product characteristics-declared sodium content of a single dose of the German OTC drugs was 157.0 mg (IQR: 98.9–417.3 mg); pain/common cold drugs contained the most sodium (median: 452.1 mg; IQR: 351.3–474.0 mg). Conclusion Effervescent tablets of nutritional supplements and OTC drugs contain high amounts of sodium, which often is not disclosed.
title: Mehrjährige Benchmarkuntersuchung zur Patientenzufriedenheit und objektiven Ergebnisqualität bei der ambulanten Katarakt-Chirurgie in Deutschland
Creators: name: Eloka, Owino
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Im Rahmen dieses Versorgungsforschungsprojektes werden medizinische Parameter und Daten zur Patientenzufriedenheit in der ambulanten Katarakt-Chirurgie in Deutschland erfasst, analysiert und ausgewertet. Mit Hilfe dieser Daten ist es möglich, Operateure umfänglich über objektive[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
title: Die Ergebnisse nach der Implantation der individualisierten Lentis Mplus toric in Augen mit Amblyopie
Creators: name: Rau, Magda
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Beurteilung der optischen und funktionellen Ergebnisse und der Patientenzufriedenheit nach der Implantation von Mplus toric in Augen mit anisometropischer Amblyopie     Methode: Nach der coaxialen Mikro Phako wurde Lentis Mplus toric in 10 Augen von 10 Patienten implantiert. Die präoperative,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
title: Refraktive und diffraktive optische Prinzipien bei Intraokularlinsen mit erweitertem Fokusbereich (EDOF IOL). Vergleich der visuellen Ergebnisse und Photopsien (P, B)
Creators: name: Hagen, Philipp
name: Breyer, Detlev
name: Kaymak, Hakan
name: Klabe, Karsten
name: Kretz, Florian
name: Auffarth, Gerd
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Diese retrospektive Analyse beinhaltet Ergebnisse nach bilateraler Implantation von EDOF IOL. Wir betrachteten die dabei Unterschiede zwischen refraktiven und diffraktiven Linsensystemen und zwar im Bezug auf binokulare Defokuskurven sowie das postoperative Auftreten von Photopsien.    [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
title: Augendrucksenkung nach Implantation von trabekulären Stents
Creators: name: Best, Ulrich-Peter
name: Domack, Harry
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: In dieser prospektiven einfach verblindeten Studie haben wir die Langzeitergebnisse nach trabekulärer Mikro-Bypass Stent Implantation in Augen mit Chronischem Offenwinkelglaukom untersucht.    Methode: In die Studie aufgenommen wurden 39 Augen mit einem Primär Chronischen Offenwinkelglaukom[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
Uterine scars after caesarean delivery: From histology to the molecular and ultrastructural level
Creators: name: Paping, Alexander
name: Basler, Clara
name: Ehrlich, Loreen
name: Fasting, Carlo
name: Melchior, Kerstin
name: Ziska, Thomas
name: Thiele, Mario
name: Duda, Georg N.
name: Timm, Sara
name: Ochs, Matthias
name: Rancourt, Rebecca C.
name: Henrich, Wolfgang
name: Braun, Thorsten
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: caesarean section
subject: collagen
subject: tissue remodelling
subject: uterine rupture
subject: uterine wound healing
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Uterine rupture during a trial of labor after caesarean delivery (CD) is a serious complication for mother and fetus. The lack of knowledge on histological features and molecular pathways of uterine wound healing has hindered research in this area from evolving over time. We analysed collagen content and turnover in uterine scars on a histological, molecular and ultrastructural level. Therefore, tissue samples from the lower uterine segment were obtained during CD from 16 pregnant women with at least one previous CD, from 16 pregnant women without previous CD, and from 16 non-pregnant premenopausal women after hysterectomy for a benign disease. Histomorphometrical collagen quantification showed, that the collagen content of the scar area in uterine wall specimens after previous CD was significantly higher than in the unscarred myometrium of the same women and the control groups. Quantitative real-time PCR of uterine scar tissue from FFPE samples delineated by laser microdissection yielded a significantly higher COL3A1 expression and a significantly lower COL1A2/COL3A1 ratio in scarred uteri than in samples from unscarred uteri. Histological collagen content and the expression of COL1A2 and COL3A1 were positively correlated, while COL1A2/COL3A1 ratio was negatively correlated with the histological collagen content. Transmission electron microscopy revealed a destroyed myometrial ultrastructure in uterine scars with increased collagen density. We conclude that the high collagen content in uterine scars results from an ongoing overexpression of collagen I and III. This is a proof of concept to enable further analyses of specific factors that mediate uterine wound healing.
Belastendes unterhaltsam thematisieren: Das Lebensende als Stadtrundgang
Creators: name: Michel, Claudia
name: Fraefel, Carmen
name: Marchand, Annabelle
name: Filippi, Andrea
Publisher: name: Berner Fachhochschule, Soziale Arbeit
Year: 2025
Subjects: Lebensende
Tod
Trauer
Sterben

description: Wie kann man die Bevölkerung für Fragen am Lebensende sensibilisieren? Schliesslich ist das Sterben für viele ein belastendes Thema, mit dem sie sich ungern auseinandersetzen. Diese Frage stellten sich auf Sterben, Tod und Trauer spezialisierte Fachorganisationen, die in Bern ein Stadtfestival zum Thema Endlichkeit organisierten. Als Resultat entstanden von BFH-Studierenden entwickelte Stadtrundgänge.
Additional file 2 of Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Creators: name: Cui, Pin
name: Zhou, Xiaozhou
name: Xu, Shu
name: He, Weihuang
name: Huang, Guozeng
name: Xiong, Yong
name: Zhang, Chuxin
name: Chang, Tingmin
name: Feng, Mingji
name: Lai, Hanming
name: Pan, Yi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 2. Figure S2. The GO directed acyclic graphs for the unique biomarker genes of Lung cancer group.
Use of mHealth to promote healthy ageing and support delivery of age-friendly health and long-term care services–A systematic review
Creators: name: Liaw, Siaw-Teng
name: Ansari, Sameera
name: Jonnagaddala, Jitendra
name: Narasimhan, Padmanesan
name: Ashraf, Md Mahfuz
name: Harris-Roxas, Ben
name: Harris, Mark
name: Liaw, Teng
Publisher: name: UNSW Sydney
Year: 2018

description: 2018 Primary Health Care Research Conference; Melbourne, Australia; 2018-08-01 - 2018-08-03
title: Kanaloplastik – Dortmunder Ergebnisse mithilfe des iTrack 250A und des Glaucolight Katheters
Creators: name: Kontopoulou, Kalliopi
name: Kohlhaas, Markus
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Die Kanaloplastik gehört zu den nichtpenetrierenden Operationen für die Behandlung des Glaukoms. Ziel ist die langfristige Effektivität der Kanaloplastik sowie der Kanaloplastik kombiniert mit der Katarakt-Operation mithilfe des iTrack 250A und des Glaucolight Katheters zu[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 30. Internationaler Kongress der Deutschen Ophthalmochirurgen
“They just won't listen”—The role of blame in narratives of past extreme weather events for anticipating future crisis
Creators: name: Jasmina, Schmidt
name: Nikola, Tietze
name: Lars, Gerhold
name: Thomas, Kox
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: anticipation
subject: blame
subject: forest fire control
subject: narratives
subject: road safety
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::551 Geologie, Hydrologie, Meteorologie

description: The phase before an extreme weather event is crucial for the actual reaction to the impacts of such an event. In this phase, professionals in the field of civil protection and emergency management anticipate the intensity and impact of the event and use these expectations for action. We argue that anticipation is—beyond others—shaped by the organizations’ shared narratives of past crisis that resulted from extreme weather events. The findings focus on the frame of ‘blame’ in the narration and are based on two fields of study, road maintenance services and forest fire control. Qualitative group discussions and semistructured interviews show two very different views on blame depending on the organization: human factors and fate. This contrast can be traced back to the character of the weather events itself, but also with the self-image of the organization and perceived external expectations. Depending on the narrative plot and threshold of the event, narratives can affect and alter practices of anticipation through narrations of renewal. Findings contribute to the understanding of organizational sensemaking through narratives of blame and consequences.
Evaluating the evidence: a systematic review of reviews of the effectiveness and safety of digital interventions for ADHD
Creators: name: Gabarron, Elia
name: Denecke, Kerstin
name: Lopez-Campos, Guillermo
Year: 2025
Subjects: ADHD
Attention-Deficit/Hyperactivity Disorder
Systematic Review
Digital Health
Adverse effects †

description: Background Attention-Deficit/Hyperactivity Disorder (ADHD) impacts academics, work and social relationships. Digital interventions, such as virtual reality, games, app and other, offer accessible therapeutic options, yet understanding their efficacy and potential adverse effects is crucial for safe use. The objective of this study is to identify and analyze the efficacy and adverse effects reported in systematic reviews of digital interventions for ADHD. Methods We conducted a systematic review of systematic reviews to assess the reported efficacy and safety of digital interventions for ADHD. We searched for relevant publications in Scopus, PubMed, PsycINFO and Cochrane Library. Both study selection and data extraction were performed in duplicate to ensure accuracy and reduce bias. This review followed PRISMA 2020 guidelines, PRISMA-harms checklist, and we used AMSTAR-2 to assess the quality and risk of bias of the included reviews. Results A total of 26 systematic reviews on digital interventions for ADHD were included. These reviews collectively involved 34,442 participants, with the majority focusing on children and adolescents. The digital interventions analyzed included video games, computerized cognitive training, virtual reality, apps, and others. The outcomes reported various positive effects, such as improvements in inattention and executive function, though evidence was generally low quality. Adverse effects were reported in 8 of the 26 included reviews (30,1%), and included physical discomfort, emotional reactions, and behavioral issues, such as video game addiction. Conclusions This systematic review of systematic reviews indicates that while digital interventions for ADHD show potential benefits, their effectiveness remains inconclusive due to low evidence quality. Adverse effects, particularly from video games, have been reported but are inconsistently documented. Future research should focus on rigorous safety assessments, standardized reporting, and long-term effectiveness. Trial registration This systematic review is registered in Prospero: CRD42024521084.
Use of mHealth to promote healthy ageing and support delivery of Heading age-friendly placement health and long-term care services: A systematic review
Creators: name: Liaw, Siaw-Teng
name: Ansari, Sameera
name: Jonnagaddala, Jitendra
name: Narasimhan, Padmanesan
name: Ashraf, Md Mahfuz
name: Harris-Roxas, Ben
name: Harris, Mark
Publisher: name: UNSW Sydney
Year: 2019

description: 19th International Conference on Integrated Care; San Sebastian, Basque Country; 2019-04-01 - 2019-04-03
Technostress : Stress durch Technologie
Creators: name: Eichenberger, Naíma
name: Golz, Christoph
Publisher: name: Schweizer Berufsverband der Pflegefachfrauen und Pflegefachmänner
Year: 2025

description: Der pflegerische Alltag wird zunehmend digitalisiert. Doch häufig erleben Pflegende bei der Nutzung von Technologien im Arbeitsalltag mehr Stress als Entlastung. Eine Studie ging der Frage nach, was dieser Technostress bei Pflegenden im Akutspital verursacht und wie dies mit der Arbeitszufriedenheit im Zusammenhang steht.
Additional file 3 of Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Creators: name: Cui, Pin
name: Zhou, Xiaozhou
name: Xu, Shu
name: He, Weihuang
name: Huang, Guozeng
name: Xiong, Yong
name: Zhang, Chuxin
name: Chang, Tingmin
name: Feng, Mingji
name: Lai, Hanming
name: Pan, Yi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 3. Figure S3. The GO directed acyclic graphs for the unique biomarker genes of Colorectal cancer group.
„... Jer dok smo mi ratovali ...“ – Pobuna dijela 1. krajiškog korpusa tzv. Vojske Republike Srpske
Creators: name: Omerčić, Edin
Publisher: name: Humanities Commons
Year: 2023

description: Based on the relevant archival material, press and literature, this text will discuss the rebellion of the part of the First Krajina Corps of the so-called Army of the Republika Srpska in Banja Luka. The uprising called action „September ‘93“ began on September 9, 1993 and ended in about ten days. In addition to the pronounced social dissatisfaction, it also had much deeper political reasons, which are revealed by transcripts from the sessions of the National Assembly of the Republika Srpska and the Supreme Defense Council of Federal Republic of Yugoslavia. The sessions showed the attitudes of the Serbian political elite and the military leadership in Republika Srpska towards this event. Based on exhaustively analyzed sources, the author raises the question of whether Radovan Karažić initiated and instigated the Rebelli- on, which was nominally directed against „war profiteers“, with the aim of consolidating his power by homogenizing the political structures of the SDS.
Controlling the interaction between CaMKII and Calmodulin with a photocrosslinking unnatural amino acid
Creators: name: Lučić, Iva
name: Jiang, Pin‐Lian
name: Franz, Andreas
name: Bursztyn, Yuval
name: Liu, Fan
name: Plested, Andrew J. R.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: calcium
subject: crosslinking
subject: kinase
subject: UV
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Using unnatural amino acid mutagenesis, we made a mutant of CaMKII that forms a covalent linkage to Calmodulin upon illumination by UV light. Like wild-type CaMKII, the L308BzF mutant stoichiometrically binds to Calmodulin, in a calcium-dependent manner. Using this construct, we demonstrate that Calmodulin binding to CaMKII, even under these stochiometric conditions, does not perturb the CaMKII oligomeric state. Furthermore, we were able to achieve activation of CaMKII L308BzF by UV-induced binding of Calmodulin, which, once established, is further insensitive to calcium depletion. In addition to the canonical auto-inhibitory role of the regulatory segment, inter-subunit crosslinking in the absence of CaM indicates that kinase domains and regulatory segments are substantially mobile in basal conditions. Characterization of CaMKIIL308BzF in vitro, and its expression in mammalian cells, suggests it could be a promising candidate for control of CaMKII activity in mammalian cells with light.
The K+ transporter NPF7.3/NRT1.5 and the proton pump AHA2 contribute to K+ transport in Arabidopsis thaliana under K+ and NO3 - deficiency
Creators: name: Sena, Florencia
name: Kunze, Reinhard
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Arabidopsis thaliana
subject: nitrate deficiency
subject: potassium deficiency
subject: potassium transport
subject: protein-protein interaction
subject: plasma membrane
subject: H+ -ATPase
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Nitrate (NO3-) and potassium (K+) are distributed in plants via short and long-distance transport. These two pathways jointly regulate NO3- and K+ levels in all higher plants. The Arabidopsis thaliana transporter NPF7.3/NRT1.5 is responsible for loading NO3- and K+ from root pericycle cells into the xylem vessels, facilitating the long-distance transport of NO3- and K+ to shoots. In this study, we demonstrate a protein-protein interaction of NPF7.3/NRT1.5 with the proton pump AHA2 in the plasma membrane by split ubiquitin and bimolecular complementation assays, and we show that a conserved glycine residue in a transmembrane domain of NPF7.3/NRT1.5 is crucial for the interaction. We demonstrate that AHA2 together with NRT1.5 affects the K+ level in shoots, modulates the root architecture, and alters extracellular pH and the plasma membrane potential. We hypothesize that NRT1.5 and AHA2 interaction plays a role in maintaining the pH gradient and membrane potential across the root pericycle cell plasma membrane during K+ and/or NO3- transport.
sj-pdf-1-ajs-10.1177_03635465211004946 – Supplemental material for Anterior Cruciate Ligament Reconstruction Alone Versus With Lateral Extra-articular Tenodesis With Minimum 2-Year Follow-up: A Meta-analysis and Systematic Review of Randomized Controlled Trials
Creators: name: Onggo, James Randolph
name: Rasaratnam, Hari Krishnan
name: Mithun Nambiar
name: Onggo, Jason Derry
name: Vishal Pai
name: Iswadi Damasena
name: Riazi, Arash
name: Babazadeh, Sina
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211004946 for Anterior Cruciate Ligament Reconstruction Alone Versus With Lateral Extra-articular Tenodesis With Minimum 2-Year Follow-up: A Meta-analysis and Systematic Review of Randomized Controlled Trials by James Randolph Onggo, Hari Krishnan Rasaratnam, Mithun Nambiar, Jason Derry Onggo, Vishal Pai, Iswadi Damasena, Arash Riazi and Sina Babazadeh in The American Journal of Sports Medicine
HKB Encore : CAS Werk- und Nachlass-Management
Creators: name: Horst, Maria
name: Bader, Eva
name: Pouly, Ursula
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2025

description: Im Interview mit der HKB-Zeitung erzählt die Historikerin und HKB-Alumna Ursula Pouly, warum und wie sie sich dem künstlerischen Nachlass-Management von Alois Lichtsteiner widmet.
Innovations in Artificial Intelligence Research Fueled by Big Data Analytics
Creators: name: Adams, Harper
name: Hall, Daniel
name: Hall, Daniel
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Artificial intelligence
subject: Big data

description: In recent years, the exponential growth of digital data has presented a remarkable opportunity and challenge for the field of artificial intelligence (AI). This paper provides a comprehensive examination of the profound influence of big data on AI advancements. With the advent of extensive data sources and improved data processing techniques, AI has made significant strides in various domains, including machine learning, natural language processing, computer vision, and more. This study reviews key developments in the intersection of big data and AI, offering insights into the ways in which big data has reshaped the landscape of AI research, applications, and industry. It assesses how AI-driven insights from massive datasets have not only improved decision-making processes but have also transformed entire industries by unlocking new opportunities and efficiencies. The synergy between artificial intelligence (AI) and big data analytics has ushered in a new era of innovation and transformative possibilities. This abstract presents a comprehensive overview of how big data analytics is driving breakthroughs in AI research, highlighting key advancements, applications, and implications.
A Comparative Analysis of Query Processing Techniques for Big Data
Creators: name: Lewis, Lily
name: Lewis, Lily
name: Scott, Christopher
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Big data

description: In the era of big data, efficient query processing is paramount for organizations seeking valuable insights from vast and diverse datasets. This paper presents a comprehensive comparative analysis of various query processing techniques tailored for big data environments. The study evaluates the performance, scalability, and adaptability of these techniques, shedding light on their strengths and weaknesses. Ultimately, this research serves as a valuable resource for data architects, engineers, and analysts faced with the task of selecting the most appropriate query processing technique for their big data projects. It provides insights into the trade-offs and considerations necessary to harness the full potential of big data analytics while optimizing resource utilization and query response times. The evaluation is conducted through a series of experiments on benchmark datasets and workloads that mimic real-world scenarios.
Understanding the protective effect of social support on depression symptomatology from a longitudinal network perspective
Creators: name: Li, Gen
name: Li, Yifan
name: Lam, Agnes Iok Fong
name: Tang, Weiming
name: Seedat, Soraya
name: Barbui, Corrado
name: Papola, Davide
name: Panter-Brick, Catherine
name: Waerden, Judith Van Der
name: Bryant, Richard
name: Mittendorfer-Rutz, Ellenor
name: Gémes, Katalin
name: Purba, Fredrick D
name: Setyowibowo, Hari
name: Pinucci, Irene
name: Palantza, Christina
name: Acarturk, Ceren
name: Kurt, Gülşah
name: Tarsitani, Lorenzo
name: Morina, Naser
name: Burchert, Sebastian
name: Patanè, Martina
name: Quero, Soledad
name: Campos, Daniel
name: Huizink, Anja C
name: Fuhr, Daniela C
name: Spiller, Tobias
name: Sijbrandij, Marit
name: Hall, Brian J
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: depression & mood disorders
subject: adult psychiatry
subject: COVID-19
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Background Higher social support protects people from developing mental disorders. Limited evidence is available on the mechanism through which social support plays this protective role. Objective To investigate the stress-buffering process of social support on depressive symptoms using a novel longitudinal dynamic symptom network approach. Methods A total of 4242 adult participants who completed the first two waves (from May to October 2020) of the International Covid Mental Health Survey were included in the study. Cross-lagged panel network modelling was used to estimate a longitudinal network of self-reported social support, loneliness and depressive symptoms. Standardised regression coefficients from regularised cross-lagged regressions were estimated as edge weights of the network. Findings The results support a unidirectional protective effect of social support on key depressive symptoms, partly mediated through loneliness: A higher number of close confidants and accessible practical help was associated with decreased anhedonia (weight=−0.033) and negative self-appraisal symptoms (weight=−0.038). Support from others was also negatively associated with loneliness, which in turn associated with decreased depressed mood (weight=0.086) and negative self-appraisal (weight=0.077). We identified a greater number of direct relationships from social support to depressive symptoms among men compared with women. Also, the edge weights from social support to depression were generally stronger in the men’s network. Conclusions Reductions in negative self-appraisal might function as a bridge between social support and other depressive symptoms, and, thus, it may have amplified the protective effect of social support. Men appear to benefit more from social support than women. Clinical implications Building community-based support networks to deliver practical support, and loneliness reduction components are critical for depression prevention interventions after stressful experiences.
Optimizing Query Processing for Big Data: A Comprehensive Review
Creators: name: Rodriguez, Sophia
name: Turner, Mason
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Big data

description: The proliferation of big data has reshaped the landscape of data management, necessitating innovative approaches to query processing. This research paper presents a comprehensive review of query processing techniques tailored to the unique challenges posed by big data environments. The paper incorporates real-world case studies that showcase successful implementations of advanced query processing techniques within organizations across various industries. These case studies underscore the practical impact of optimized query processing on data-driven decision-making and analytics.
Additional file 4 of Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED)
Creators: name: Cui, Pin
name: Zhou, Xiaozhou
name: Xu, Shu
name: He, Weihuang
name: Huang, Guozeng
name: Xiong, Yong
name: Zhang, Chuxin
name: Chang, Tingmin
name: Feng, Mingji
name: Lai, Hanming
name: Pan, Yi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Additional file 4. Figure S4. The GO directed acyclic graphs for the shared biomarker genes among three cancer groups.
sj-pdf-1-ajs-10.1177_03635465211000763 – Supplemental material for Treatment Strategies and Outcomes for Osteochondritis Dissecans of the Capitellum
Creators: name: Sayani, Junaid
name: Plotkin, Tobias
name: Burchette, Daniel Timothy
name: Phadnis, Joideep
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211000763 for Treatment Strategies and Outcomes for Osteochondritis Dissecans of the Capitellum by Junaid Sayani, Tobias Plotkin, Daniel Timothy Burchette and Joideep Phadnis in The American Journal of Sports Medicine
Sample‐based robust model reduction for non‐linear systems biology models
Creators: name: Falkenhagen, Undine
name: Himpe, Christian
name: Knöchel, Jane
name: Kloft, Charlotte
name: Huisinga, Wilhelm
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: non-linear systems biology models
subject: sample-based approach
subject: robust model order reduction
subject: 500 Naturwissenschaften und Mathematik::510 Mathematik::510 Mathematik

description: Complex non-linear systems biology models comprise relevant knowledge on processes of pharmacological interest. They are, however, too complex to be used in inferential settings, for example, to allow for the estimation of patient-specific parameters for individual dose optimisation. Thus, there is a need for simple models with interpretable components to infer the drug effect in a clinical setting. In particular, it is essential to accurately quantify and simulate the interindividual variability in the drug response in order to account for covariates like body weight, age and genetic disposition. To this end, non-linear model order reduction and simplification methods can be used if they maintain model interpretability during reduction and consider an entire population rather than just a single reference individual. We present a sample-based approach for robust model order reduction and propose two improvements for efficiency. In particular, we introduce a new sampling method to generate the virtual population based on transformed latin hypercube sampling. Thereby, the sample is stratified in the relevant parameter-space directions, which are identified using empirical observability Gramians. We illustrate our approach in application to a blood coagulation pathway model, where we reduce the complexity from a 62-dimensional highly non-linear to a six-dimensional and a nine-dimensional system of ordinary differential equations for two scenarios, respectively.
Bridging Bytes and Business: A Research Inquiry into Big Data's Strategic Significance
Creators: name: Brooks, Ava
name: Parker, Liam
name: Parker, Liam
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Big data
subject: Artificial intelligence

description: In the era of information-driven economies, "Bridging Bytes and Business: A Research Inquiry into Big Data's Strategic Significance" serves as a scholarly exploration into the transformative nexus of data analytics and strategic business endeavors. This research delves into the strategic role played by big data in contemporary business landscapes, examining its multifaceted influence on operational efficiencies, decision-making processes, and the overall competitive advantage of organizations. Employing a meticulous research methodology that encompasses literature reviews, case studies, and real-world applications, this paper seeks to bridge the gap between the intricacies of data analytics and the strategic imperatives of modern businesses. By synthesizing insights from diverse industries, ranging from technology and finance to healthcare and beyond, our analysis aims to provide a comprehensive understanding of how big data acts as a bridge, connecting the analytical prowess of bytes with the strategic imperatives of business success.
Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins
Creators: name: Sigrist, Stephan J
name: Haucke, Volker
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: intrinsically disordered proteins
subject: membrane contact sites
subject: neurotransmission
subject: synapse
subject: vesicular and nonvesicular transport
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Compartmentalization by membranes is a common feature of eukaryotic cells and serves to spatiotemporally confine biochemical reactions to control physiology. Membrane‐bound organelles such as the endoplasmic reticulum (ER), the Golgi complex, endosomes and lysosomes, and the plasma membrane, continuously exchange material via vesicular carriers. In addition to vesicular trafficking entailing budding, fission, and fusion processes, organelles can form membrane contact sites (MCSs) that enable the nonvesicular exchange of lipids, ions, and metabolites, or the secretion of neurotransmitters via subsequent membrane fusion. Recent data suggest that biomolecule and information transfer via vesicular carriers and via MCSs share common organizational principles and are often mediated by proteins with intrinsically disordered regions (IDRs). Intrinsically disordered proteins (IDPs) can assemble via low‐affinity, multivalent interactions to facilitate membrane tethering, deformation, fission, or fusion. Here, we review our current understanding of how IDPs drive the formation of multivalent protein assemblies and protein condensates to orchestrate vesicular and nonvesicular transport with a special focus on presynaptic neurotransmission. We further discuss how dysfunction of IDPs causes disease and outline perspectives for future research.
Wenn Wissen Kreise zieht
Creators: name: Allenbach, Daniel
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2025

description: Forschen heisst lesen, untersuchen, grübeln, suchen, planen, überlegen, werweissen, mutmassen, interpretieren, extrapolieren – vor allem aber heisst es auch: schreiben, kommunizieren und publizieren. Was nützt all die schöne Forschung, wenn das neu erworbene Wissen im eigenen Kopf bleibt und nicht geteilt wird?
Un supplément publicitaire
Creators: name: Bottinelli, Colin
name: Wohlfender, Bettina
name: Renken, Arno
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2023

description: L’anthologie annuelle et bilingue La Liesette Littéraire publie des textes d’ancien∙nexs et d’actuel∙lexs étudiant∙exs de l’Institut littéraire suisse. Une rencontre avec les rédacteurices et les enseignant∙exs de la HKB Bettina Wohlfender et Arno Renken.
Wo publiziert ihr?
Creators: name: Pauli, Christian
name: Tapis, Atalja
name: Kougias, Philolaos
name: Hostettler, Fabiola
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2025

description: Das Marketing ist Bestandteil der Kunstausbildung und der Kunstkarriere. Am Roundtable der HKB-Zeitung erläutern die HKB-Studierenden Atalja Tapis (Bachelor of Arts Visuelle Kommunikation), Philolaos Kougias (Master Music Composition – Contemporary Jazz) und Fabiola Hostettler (Master of Arts Multimedia Communication & Publishing), wie sie mit Social Media umgehen und ihre Kunst publizieren.