cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In vivo characterization of carbon dots–bone interactions: toward the development of bone-specific nanocarriers for drug delivery
Creators: name: DuMez, Rachel
name: Miyanji, Esmail H.
name: Corado-Santiago, Lesly
name: Barrameda, Bryle
name: Zhou, Yiqun
name: Hettiarachchi, Sajini D.
name: Leblanc, Roger M.
name: Skromne, Isaac
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Current treatments for osteoporosis and other bone degenerative diseases predominately rely on preventing further bone erosion rather than restoring bone mass, as the latter treatments can unintentionally trigger cancer development by undiscriminatingly promoting cell proliferation. One approach to circumvent this problem is through the development of novel chemical carriers to deliver drug agents specifically to bones. We have recently shown that carbon nanodots (C-dots) synthesized from carbon nanopowder can bind with high affinity and specificity to developing bones in the larval zebrafish. Larval bones, however, are physiologically different from adult bones in their growth, repair, and regeneration properties. Here we report that C-dots can bind to adult zebrafish bones and that this binding is highly specific to areas of appositional growth. C-dots deposition occurred within 30 minutes after delivery and was highly selective, with bones undergoing regeneration and repair showing higher levels of C-dots deposition than bones undergoing normal homeostatic turnover. Importantly, C-dots deposition did not interfere with bone regeneration or the animal’s health. Together, our results establish C-dots as a potential novel vehicle for the targeted delivery of drugs to treat adult bone disease.
ACCESS I: An Optical Transmission Spectrum of GJ 1214b Reveals a Heterogeneous Stellar Photosphere
Creators: name: Rackham, Benjamin
name: Espinoza, Néstor
name: Apai, Dániel
name: López-Morales, Mercedes
name: Jordán, Andrés
name: Osip, David J.
name: Lewis, Nikole K.
name: Rodler, Florian
name: Fraine, Jonathan D.
name: Morley, Caroline V.
name: Fortney, Jonathan J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: GJ 1214b is the most studied sub-Neptune exoplanet to date. Recent measurements have shown its near-infrared transmission spectrum to be flat, pointing to a high-altitude opacity source in the exoplanet's atmosphere, either equilibrium condensate clouds or photochemical hazes. Many photometric observations have been reported in the optical by different groups, though simultaneous measurements spanning the entire optical regime are lacking. We present an optical transmission spectrum ($4,500-9,260$Å) of GJ 1214b in 14 bins measured with Magellan/IMACS repeatedly over three transits. We measure a mean planet-to-star radius ratio of ${R_{p}/R_{s} = 0.1146\pm{2\times10^{-4}}}$ and mean uncertainty of $σ(R_{p}/R_{s})=8.7\times10^{-4}$ in the spectral bins. The optical transit depths are shallower on average than observed in the near-infrared. We present a model for jointly incorporating the effects of a composite photosphere and atmospheric transmission (CPAT) through the exoplanet's limb, and use it to examine the cases of absorber and temperature heterogeneities in the stellar photosphere. We find the optical and near-infrared measurements are best explained by the combination of (1) photochemical haze in the exoplanetary atmosphere with a mode particle size $r=0.1~μ$m and haze-forming efficiency $f_{haze}=10 \%$ and (2) faculae in the unocculted stellar disk with a temperature contrast $ΔT=354^{+46}_{-46}$ K, assuming 3.2% surface coverage. The CPAT model can be used to assess potential contributions of heterogeneous stellar photospheres to observations of exoplanet transmission spectra, which will be important for searches for spectral features in the optical.
description: Accepted for publication in ApJ
Binary stars as the key to understanding planetary nebulae
Creators: name: Jones, David
name: Boffin, Henri M. J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Planetary nebulae are traditionally considered to represent the final evolutionary stage of all intermediate-mass stars ($\sim$0.7-8Msol). Recent evidence seems to contradict this picture. In particular, since the launch of the Hubble Space Telescope it has become clear that planetary nebulae display a wide range of striking morphologies which cannot be understood in a single star scenario, instead pointing towards a binary evolution in a majority of systems. Here, we summarise our current understanding of the importance of binarity in the formation and shaping of planetary nebulae, as well as the surprises that recent observational studies have revealed with respect to our understanding of binary evolution in general. These advances have critical implications, including for the understanding of mass transfer processes in binary stars - particularly the all-important but ever-so poorly understood `common envelope phase' - as well as the formation of cosmologically important type Ia supernovae.
description: 20 pages, 4 figures, Review accepted for publication in Nature Astronomy
L-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent
Creators: name: Li, Jiali
name: Jiang, Xue
name: Shang, Lihuan
name: Li, Zhen
name: Yang, Conglian
name: Luo, Yan
name: Hu, Daoyu
name: Shen, Yaqi
name: Zhang, Zhiping
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: This study aimed to synthesize and characterize L-epigallocatechin gallate (EGCG) complexed Mn2+ nanoparticle (L-EGCG-Mn), a proof-of-concept pH-sensitive manganese core nanoparticle (NP), and compare its magnetic resonance (MR) properties with those of Gd-DTPA, both in vitro and in vivo. Reverse microemulsion was used to obtain the L-EGCG-Mn NPs. The physicochemical properties of L-EGCG-Mn were characterized using dynamic light scattering, transmission electron microscopy, and near-infrared fluorescence small animal live imaging. The in vitro relaxivity of L-EGCG-Mn incubated with different pH buffer solutions (pH = 7.4, 6.8, 5.5) was evaluated. The T1-weighted MR imaging (MRI) properties were evaluated in vitro using hypoxic H22 cells as well as in H22 tumor-bearing mice. Cytotoxicity tests and histological analysis were performed to evaluate the safety of L-EGCG-Mn. L-EGCG-Mn showed good biocompatibility, stability, pH sensitivity, and tumor-targeting ability. Moreover, when the pH was decreased from 7.4 to 5.5, the r1 relaxivity of L-EGCG-Mn was shown to gradually increase from 1.79 to 6.43 mM−1·s−1. Furthermore, after incubation with L-EGCG-Mn for 4 h, the T1 relaxation time of hypoxic H22 cells was significantly lower than that of normoxic H22 cells (1788 ± 89 vs. 1982 ± 68 ms, p=.041). The in vivo analysis showed that after injection, L-EGCG-Mn exhibited a higher MRI signal compared to Gd-DTPA in H22 tumor-bearing mice (p < .05). Furthermore, L-EGCG-Mn was found to have a good safety profile via cytotoxicity tests and histological analysis. L-EGCG-Mn has a good safety profile and pH sensitivity and may thus serve as a potential MRI contrast agent.
The role of 14-3-3β in acute asthma in children and analysis of the risk factors for asthma exacerbation
Creators: name: Li, Shufang
name: Dong, Junjun
name: Li, Aijun
name: Yang, Qiuyan
name: Xiong, Xiaoman
name: Xie, Xueli
name: Zhang, Yanli
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: To investigate the role of 14-3-3β in acute asthma exacerbations in children and analyze the risk factors for asthma exacerbations. This study recruited 101 children with acute asthma exacerbations, 101 children with stable asthma, and 65 healthy children. Serum 14-3-3β was compared among the three groups. Factors such as asthma family history, skin prick test, serum-specific IgE test, coinfections, and clinical indicators (FeNO, FEV1, white blood cells, eosinophils, and serum IgE level) were compared between the asthma groups. Risk factors associated with acute asthma exacerbations were identified using multivariate logistic regression models. ROC curve was drawn to determine the diagnostic sensitivity and specificity of 14-3-3β. Serum 14-3-3β was significantly greater in the acute asthma group than in the stable asthma and control groups. Serum 14-3-3β was higher in severe acute asthma group than in mild-moderate asthma group. There were no significant differences in serum 14-3-3β levels between stable asthma and control groups (p > .05). Multivariate logistic regression analysis revealed that serum 14-3-3β level, FeNO, coinfection, and FEV1 z-score significantly increased the odds of acute asthma exacerbations in children. The optimal 14-3-3β cutoff value (39.79 ng/mL), had a sensitivity of 69.3% and specificity of 94.1% for predicting acute asthma exacerbations. 14-3-3β is elevated in children with acute exacerbations of asthma, and increases with exacerbation severity. 14-3-3β, FeNO, FEV1, and coinfection could be independent risk factors for predicting asthma exacerbations. The optimal 14-3-3β cutoff value for predicting asthma exacerbations was 39.79 ng/mL.
Efficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis
Creators: name: Fu, Wenhai
name: He, Wenjun
name: Li, Yuexin
name: Chen, Yangxiao
name: Liang, Jingyi
name: Lei, Hui
name: Fu, Lin
name: Chen, Yanghang
name: Ren, Ni
name: Jiang, Qian
name: Shen, Yi
name: Ma, Ran
name: Wang, Tao
name: Wang, Xinni
name: Zhang, Nuofu
name: Xiao, Dakai
name: Liu, Chunli
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Background: Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a poor prognosis. Although PAH medication made great advances in recent years, the efficacy and safety of the medication are unsatisfactory. Therefore, we aimed to update and expand previous studies to explore the efficacy and safety of PAH-targeted medications. Methods: Relevant articles were searched and selected from published or publicly available data in PubMed, Cochrane Library, CNKI, PsycInfo, and MEDLINE (from inception until October 1st, 2020). To assess the efficacy and safety of PAH therapies, five efficacy outcomes [6-minute walking distance (6MWD), mean pulmonary arterial pressure (mPAP), WHO functional class (WHO FC) improvement, clinical worsening, death] and two safety outcomes [adverse events (AEs), serious adverse events (SAEs)] were selected. And 6MWD was regarded as the primary efficacy outcome. Results: 50 trials included with 10 996participants were selected. In terms of efficacy, all targeted drugs were more effective than placebo. For 6MWD, Bosentan + Sildenafil, Sildenafil, Bosentan + Iloprost were better than others. Bosentan + Iloprost and Bosentan + Sildenafil were better for mPAP. Bosentan + Iloprost and Ambrisentan + Tadalafil were more effective in improving WHO FC. Bosentan + Tadalafil and Bosentan + Iloprost had the Ambrisentan probability to reduce the incidence of clinical worsening. It is demonstrated that Ambrisentan had clear benefits in reducing all-cause mortality. In terms of safety, no therapies had been shown to reduce the incidence of SAEs significantly, and Ambrisentan + Tadalafil significantly increased the incidence of AEs. Conclusions: Phosphodiesterase 5 inhibitor (PDE5i) + Endothelin Receptor Antagonists (ERA) seems to be better therapy for PAH. Prostacyclin analogs (ProsA) + ERA appear promising, though additional data is warranted. Registration PROSPERO CRD42020218818.
The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death
Creators: name: Duan, Xiao-Chuan
name: Peng, Li-Yuan
name: Yao, Xin
name: Xu, Mei-Qi
name: Li, Hui
name: Zhang, Shuai-Qiang
name: Li, Zhuo-Yue
name: Wang, Jing-Ru
name: Feng, Zhen-Han
name: Wang, Guang-Xue
name: Liao, Ai
name: Chen, Ying
name: Zhang, Xuan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD) inducers, stimulating an antitumor response which results in synergistic antitumor activity by combining anti-PD-L1 antibody (aPD-L1) in vivo. To investigate the antitumor immunity induced by NPPA-PTX NPs, the expression of both ICD marker calreticulin (CRT) and high mobility group box 1 (HMGB1) were analyzed. In addition, the antitumor activity of NPPA-PTX NPs combined with aPD-L1 in vivo was also investigated. The immune response was also measured through quantitation of the infiltration of T cells and the secretion of pro-inflammatory cytokines. The results demonstrate that NPPA-PTX NPs induce ICD of MDA-MB-231 and 4T1 cells through upregulation of CRT and HMGB1, reactivating the antitumor immunity via recruitment of infiltrating CD3+, CD4+, CD8+ T cells, secreting IFN-γ, TNF-α, and the enhanced antitumor activity by combining with aPD-L1. These data suggest that the combined therapy has a synergistic antitumor activity and has the potential to be developed into a novel therapeutic regimen for cancer patients.
Set of INVADE business models including classification framework simplified - D9.4 INVADE H2020
Creators: name: Wåge, Dagfinn
name: Fjeld, Per
name: Bremdal, Bernt
name: Puranik, Sanket
Publisher: name: Zenodo
Year: 2018

description: Our work has led to the conclusion that platform and ecosystem-based business models are disrupting all the industries they enter. We believe that the energy market will not be an exception, and that digitalisation inevitably will open the energy market for these business models. Our work has also revealed that Europe is lagging behind the US and Asia in numbers of companies exploiting platform-based business models. For this reason, we have chosen to focus our work in D9.4 on studying these new business models, trying to migrate them into the energy industry by developing a generic business model framework that can absorb the changes described above.
On Consideration of Content Preference and Sharing Willingness in D2D Assisted Offloading
Creators: name: Pan, Yijin
name: Pan, Cunhua
name: Zhu, Huiling
name: Ahmed, Qasim Zeeshan
name: Chen, Ming
name: Wang, Jiangzhou
Publisher: name: arXiv
Year: 2017
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Device-to-device (D2D) assisted offloading heavily depends on the participation of human users. The content preference and sharing willingness of human users are two crucial factors in the D2D assisted offloading. In this paper, with consideration of these two factors, the optimal content pushing strategy is investigated by formulating an optimization problem to maximize the offloading gain measured by the offloaded traffic. Users are placed into groups according to their content preferences, and share content with intergroup and intragroup users at different sharing probabilities. Although the optimization problem is nonconvex, the closed-form optimal solution for a special case is obtained, when the sharing probabilities for intergroup and intragroup users are the same. Furthermore, an alternative group optimization (AGO) algorithm is proposed to solve the general case of the optimization problem. Finally, simulation results are provided to demonstrate the offloading performance achieved by the optimal pushing strategy for the special case and AGO algorithm. An interesting conclusion drawn is that the group with the largest number of interested users is not necessarily given the highest pushing probability. It is more important to give high pushing probability to users with high sharing willingness.
description: This work has been accepted by the IEEE JSAC Special Issue on Human-In-The-Loop Mobile Networks
Detailed characterization and impact of small airway dysfunction in school-age asthma
Creators: name: Kjellberg, Sanna
name: Olin, Anna-Carin
name: Schiöler, Linus
name: Robinson, Paul D.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Small airway dysfunction (SAD) is increasingly recognized as an important feature of pediatric asthma yet typically relies on spirometry-derived FEF25–75 to detect its presence. Multiple breath washout (MBW) and oscillometry potentially offer improved sensitivity for SAD detection, but their utility in comparison to FEF25–75, and correlations with clinical outcomes remains unclear for school-age asthma. We investigated SAD occurrence using these techniques, between-test correlation and links to clinical outcomes in 57 asthmatic children aged 8–18 years. MBW and spirometry abnormality were defined as z-scores above/below ± 1.96, generating MBW reference equations from contemporaneous controls (n = 69). Abnormal oscillometry was defined as > 97.5th percentile, also from contemporaneous controls (n = 146). Individuals with abnormal FEF25–75, MBW, or oscillometry were considered to have SAD. Using these limits of normal, SAD was present on oscillometry in 63% (resistance at 5–20 Hz; R5-R20; >97.5th percentile), on MBW in 54% (Scond; z-scores> +1.96) and in spirometry FEF25–75 in 44% of participants (z-scores< −1.96). SAD, defined by oscillometry and/or MBW abnormality, occurred in 77%. Among those with abnormal R5-R20, Scond was abnormal in 71%. Correlations indicated both R5-R20 and Scond were linked to asthma medication burden, baseline FEV1 and reversibility. Additionally, Scond correlated with FENO and magnitude of bronchial hyper-responsiveness. SAD, detected by oscillometry and/or MBW, occurred in almost 80% of school-aged asthmatic children, surpassing FEF25–75 detection rates. Discordant oscillometry and MBW abnormality suggests they reflect different aspects of SAD, serving as complementary tools. Key asthma clinical features, like reversibility, had stronger correlation with MBW-derived Scond than oscillometry-derived R5-R20.
Nonparametric Rotations for Sphere-Sphere Regression
Creators: name: Marzio, Marco Di
name: Panzera, Agnese
name: Taylor, Charles C.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Regression of data represented as points on a hypersphere has traditionally been treated using parametric families of transformations that include the simple rigid rotation as an important, special case. On the other hand, nonparametric methods have generally focused on modeling a scalar response through a spherical predictor by representing the regression function as a polynomial, leading to component-wise estimation of a spherical response. We propose a very flexible, simple regression model where for each location of the manifold a specific rotation matrix is to be estimated. To make this approach tractable, we assume continuity of the regression function that, in turn, allows for approximations of rotation matrices based on a series expansion. It is seen that the nonrigidity of our technique motivates an iterative estimation within a Newton–Raphson learning scheme, which exhibits bias reduction properties. Extensions to general shape matching are also outlined. Both simulations and real data are used to illustrate the results. Supplementary materials for this article are available online.
Nonparametric rotations for sphere-sphere regression
Creators: name: Marzio, Marco Di
name: Panzera, Agnese
name: Taylor, Charles C.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Regression of data represented as points on a hypersphere has traditionally been treated using parametric families of transformations that include the simple rigid rotation as an important, special case. On the other hand, nonparametric methods have generally focused on modelling a scalar response through a spherical predictor by representing the regression function as a polynomial, leading to component-wise estimation of a spherical response. We propose a very flexible, simple regression model where for each location of the manifold a specific rotation matrix is to be estimated. To make this approach tractable, we assume continuity of the regression function that, in turn, allows for approximations of rotation matrices based on a series expansion. It is seen that the non-rigidity of our technique motivates an iterative estimation within a Newton-Raphson learning scheme which exhibits bias reduction properties. Extensions to general shape matching are also outlined. Both simulations and real data are used to illustrate the results.
title: Testing soil nematode extraction efficiency using different variations of the Baermann-funnel method
Creators: name: Cesarz, Simone
name: Schulz, Annika Eva
name: Beugnon, Rémy
name: Eisenhauer, Nico
Publisher: name: SOIL ORGANISMS 91(2)
Year: 2019

description: soil organisms | comparability | reproducibility | extraction methods
CC2 oscillator strengths within the local framework for calculating excitation energies (LoFEx)
Creators: name: Baudin, Pablo
name: Kjærgaard, Thomas
name: Kristensen, Kasper
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: In a recent work [Baudin and Kristensen, J. Chem. Phys. 144, 224106 (2016)], we introduced a local framework for calculating excitation energies (LoFEx), based on second-order approximated coupled cluster (CC2) linear-response theory. LoFEx is a black-box method in which a reduced excitation orbital space (XOS) is optimized to provide coupled cluster (CC) excitation energies at a reduced computational cost. In this article, we present an extension of the LoFEx algorithm to the calculation of CC2 oscillator strengths. Two different strategies are suggested, in which the size of the XOS is determined based on the excitation energy or the oscillator strength of the targeted transitions. The two strategies are applied to a set of medium-sized organic molecules in order to assess both the accuracy and the computational cost of the methods. The results show that CC2 excitation energies and oscillator strengths can be calculated at a reduced computational cost, provided that the targeted transitions are local compared to the size of the molecule. To illustrate the potential of LoFEx for large molecules, both strategies have been successfully applied to the lowest transition of the bivalirudin molecule (4255 basis functions) and compared with time-dependent density functional theory.
description: 29 pages (preprint format), 3 figures
Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment
Creators: name: Wang, Yu
name: Wang, Qianmei
name: Feng, Wei
name: Yuan, Qian
name: Qi, Xiaowei
name: Chen, Sheng
name: Yao, Pu
name: Dai, Qing
name: Xia, Peiyuan
name: Zhang, Dinglin
name: Sun, Fengjun
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-αCD NPs) and FA-modified Lut/Oxi-αCD NPs (Lut/FA-Oxi-αCD NPs) is 210.5 ± 6.1 and 196.7 ± 1.8 nm, respectively. Both Lut/Oxi-αCD NPs and Lut/FA-Oxi-αCD NPs have high drug loading (14.83 ± 3.50 and 16.37 ± 1.47%, respectively). In vitro cellular assays verified that these NPs could be efficiently internalized by 4T1 cells and the released Lut from NPs could inhibit tumor cells proliferation significantly. Animal experiments demonstrated that Lut/Oxi-αCD NPs, especially Lut/FA-Oxi-αCD NPs obviously accumulated at tumor sites, and inhibited tumor growth ∼3 times compared to the Lut group. In conclusion, the antitumor efficacy of Lut was dramatically improved by targeting delivery with the ROS-responsive nanoplatforms.
Additional file 8 of Whole-genome resequencing of wild and cultivated cannabis reveals the genetic structure and adaptive selection of important traits
Creators: name: Chen, Xuan
name: Guo, Hong-Yan
name: Zhang, Qing-Ying
name: Wang, Lu
name: Guo, Rong
name: Zhan, Yi-Xun
name: Lv, Pin
name: Xu, Yan-Ping
name: Guo, Meng-Bi
name: Zhang, Yuan
name: Zhang, Kun
name: Liu, Yan-Hu
name: Yang, Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 8: Fig. S2. Summary of nucleotide diversity and correlations between latitude and diversity among cultivated cannabis accessions. A Nucleotide diversity calculated for each individual and plotted based on different groups interms of population structure. The boxes and inside lines represent quartile ranges and median values, respectively. B Scatterplot and linear fitting curve of the latitude and diversity of 13 cultivated cannabis varieties (C1-C6, C9-C12, YNN, GXI and SCN), with some admixed samples removed. C Correlations between latitude and diversity among the 13 cultivated cannabis accessions.
Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies
Creators: name: Albash, Rofida
name: Fahmy, Abdurrahman M.
name: Hamed, Mohammed I.A.
name: Darwish, Khaled M.
name: El-Dahmy, Rania Moataz
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Spironolactone (SP) is a potassium sparing diuretic with antiandrogenic properties. This study aimed at formulating SP into hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism. HAECs were prepared by ethanol injection method, according to D-optimal design, after a proper in silico study. HAECs were evaluated by measuring their entrapment efficiency (EE%), particle size (PS), and polydispersity index (PDI). Optimal hyaluronic acid enriched cerosomes (OHAECs) were subjected to further in vitro and ex-vivo and in-vivo studies. The in silico study concluded better interactions between SP and phosphatidyl choline in presence of hyaluronic acid (HA) and high stability of their binding in water. The prepared HAECs had acceptable EE%, PS, and PDI values. The statistical optimization process suggested OHAEC containing 10.5 mg ceramide III and 15 mg HA, utilizing Kolliphor® RH40. OHAEC had EE% and PS of 89.3 ± 0.3% and 261.8 ± 7.0 nm, respectively. OHAEC was stable for up to 3 months. It also showed a mixed tubular and vesicular appearance under transmission electron microscope. The ex vivo and in vivo studies concluded better skin deposition and accumulation of SP from OHAEC. The histopathological study demonstrated the safety of OHAEC for topical application. Therefore, OHAEC could be considered as effective system for topical application of SP to manage hirsutism, with prolonged action, coupled with minimized side effects.
Stochastic Quasi-likelihood for Case-Control Point Pattern Data
Creators: name: Ganggang Xu
name: Waagepetersen, Rasmus
name: Yongtao Guan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We propose a novel stochastic quasi-likelihood estimation procedure for case-control point processes. Quasi-likelihood for point processes depends on a certain optimal weight function and for the new method the weight function is stochastic since it depends on the control point pattern. The new procedure also provides a computationally efficient implementation of quasi-likelihood for univariate point processes in which case a synthetic control point process is simulated by the user. Under mild conditions, the proposed approach yields consistent and asymptotically normal parameter estimators. We further show that the estimators are optimal in the sense that the associated Godambe information is maximal within a wide class of estimating functions for case-control point processes. The effectiveness of the proposed method is further illustrated using extensive simulation studies and two data examples.
Foreign-language Reviews: Help or Hindrance?
Creators: name: Hale, Scott A.
name: Eleta, Irene
Publisher: name: arXiv
Year: 2017
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Computation and Language (cs.CL)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: H.5.m

description: The number and quality of user reviews greatly affects consumer purchasing decisions. While reviews in all languages are increasing, it is still often the case (especially for non-English speakers) that there are only a few reviews in a person's first language. Using an online experiment, we examine the value that potential purchasers receive from interfaces showing additional reviews in a second language. The results paint a complicated picture with both positive and negative reactions to the inclusion of foreign-language reviews. Roughly 26-28% of subjects clicked to see translations of the foreign-language content when given the opportunity, and those who did so were more likely to select the product with foreign-language reviews than those who did not.
“Detailed characterization and impact of small airway dysfunction in school-age asthma”
Creators: name: Kjellberg, Sanna
name: Olin, Anna-Carin
name: Schiöler, Linus
name: Paul, D Robinson
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Small airway dysfunction (SAD) is increasingly recognized as an important feature of pediatric asthma yet typically relies on spirometry-derived FEF25-75 to detect its presence. Multiple breath washout (MBW) and oscillometry potentially offer improved sensitivity for SAD detection, but their utility in comparison to FEF25-75, and correlations with clinical outcomes remains unclear for school-age asthma. We investigated SAD occurrence using these techniques, between-test correlation and links to clinical outcomes in 57 asthmatic children aged 8-18 years. MBW and spirometry abnormality were defined as z-scores above/below ± 1.96, generating MBW reference equations from contemporaneous controls (n = 69). Abnormal oscillometry was defined as > 97.5th percentile, also from contemporaneous controls (n = 146). Individuals with abnormal FEF25-75, MBW, or oscillometry were considered to have SAD. Using these limits of normal, SAD was present on oscillometry in 63% (resistance at 5-20 Hz; R5-R20; >97.5th percentile), on MBW in 54% (Scond; z-scores> +1.96) and in spirometry FEF25-75 in 44% of participants (z-scores<-1.96). SAD, defined by oscillometry and/or MBW abnormality, occurred in 77%. Among those with abnormal R5-R20, Scond was abnormal in 71%. Correlations indicated both R5-R20 and Scond were linked to asthma medication burden, baseline FEV1 and reversibility. Additionally, Scond correlated with FENO and magnitude of bronchial hyper-responsiveness. SAD, detected by oscillometry and/or MBW, occurred in almost 80% of school-aged asthmatic children, surpassing FEF25-75 detection rates. Discordant oscillometry and MBW abnormality suggests they reflect different aspects of SAD, serving as complementary tools. Key asthma clinical features, like reversibility, had stronger correlation with MBW-derived Scond than oscillometry-derived R5-R20.
Nonparametric causal effects based on incremental propensity score interventions
Creators: name: Kennedy, Edward H.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 60506 Virology

description: Most work in causal inference considers deterministic interventions that set each unit's treatment to some fixed value. However, under positivity violations these interventions can lead to non-identification, inefficiency, and effects with little practical relevance. Further, corresponding effects in longitudinal studies are highly sensitive to the curse of dimensionality, resulting in widespread use of unrealistic parametric models. We propose a novel solution to these problems: incremental interventions that shift propensity score values rather than set treatments to fixed values. Incremental interventions have several crucial advantages. First, they avoid positivity assumptions entirely. Second, they require no parametric assumptions and yet still admit a simple characterization of longitudinal effects, independent of the number of timepoints. For example, they allow longitudinal effects to be visualized with a single curve instead of lists of coefficients. After characterizing incremental interventions and giving identifying conditions for corresponding effects, we also develop general efficiency theory, propose efficient nonparametric estimators that can attain fast convergence rates even when incorporating flexible machine learning, and propose a bootstrap-based confidence band and simultaneous test of no treatment effect. Finally we explore finite-sample performance via simulation, and apply the methods to study time-varying sociological effects of incarceration on entry into marriage.
On the spectral curvature of VHE blazar 1ES\,1011+496: Effect of spatial particle diffusion
Creators: name: Sinha, Atreyee
name: Sahayanathan, S.
name: Acharya, B. S.
name: Anupama, G. C.
name: Chitnis, V. R.
name: Singh, B. B.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A detailed multi-epoch study of the broadband spectral behaviour of the very high energy (VHE) source, 1ES\,1011+496, provides us with valuable information regarding the underlying particle distribution. Simultaneous observations of the source at optical/ UV/ X-ray/ $γ$-ray during three different epochs, as obtained from Swift-UVOT/ Swift-XRT/ Fermi-LAT, are supplemented with the information available from the VHE telescope array, HAGAR. The longterm flux variability at the Fermi-LAT energies is clearly found to be lognormal. It is seen that the broadband spectral energy distribution (SED) of 1ES\,1011+496 can be successfully reproduced by synchrotron and synchrotron self Compton emission models. Notably, the observed curvature in the photon spectrum at X-ray energies demands a smooth transition of the underlying particle distribution from a simple power law to a power law with an exponential cutoff or a smooth broken power law distribution, which may possibly arise when the escape of the particles from the main emission region is energy dependent. Specifically, if the particle escape rate is related to its energy as $E^{0.5}$ then the observed photon spectrum is consistent with the ones observed during the various epochs.
description: 29 pages, 8 figures; Accepted in ApJ
Targeted therapy of rheumatoid arthritis via macrophage repolarization
Creators: name: Zhou, Xu
name: Huang, Dandan
name: Wang, Runkong
name: Wu, Mingquan
name: Zhu, Liyang
name: Peng, Wei
name: Tu, He
name: Deng, Xuangeng
name: Zhu, He
name: Zhang, Zhong
name: Wang, Xinming
name: Cao, Xi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Science Policy

description: The polarization of macrophages plays a critical role in the physiological and pathological progression of rheumatoid arthritis (RA). Activated M1 macrophages overexpress folate receptors in arthritic joints. Hence, we developed folic acid (FA)-modified liposomes (FA-Lips) to encapsulate triptolide (TP) (FA-Lips/TP) for the targeted therapy of RA. FA-Lips exhibited significantly higher internalization efficiency in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells than liposomes (Lips) in the absence of folate. Next, an adjuvant-induced arthritis (AIA) rat model was established to explore the biodistribution profiles of FA-Lips which showed markedly selective accumulation in inflammatory paws. Moreover, FA-Lips/TP exhibited greatly improved therapeutic efficacy and low toxicity in AIA rats by targeting M1 macrophages and repolarizing macrophages from M1 to M2 subtypes. Overall, a safe FA-modified liposomal delivery system encapsulating TP was shown to achieve inflammation-targeted therapy against RA via macrophage repolarization.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0199v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0199v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0199v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
Optimisation of benefits from agriculture and wildlife land uses by wards in CAMPFIRE areas in Zimbabwe
Creators: name: Mwakiwa, Emmanuel
name: Mwakiwa, Emmanuel
Publisher: name: Unknown
Year: 2019
Subjects: subject: Environmental Economics and Policy
subject: agriculture
subject: hunting area
subject: Pontryagin’s maximum principle
subject: rural district council
subject: wildlife

description: To arrest the ongoing ecological disaster in the country, the government of Zimbabwe implemented the Communal Areas Management Programme for Indigenous Resources (CAMPFIRE). Through the CAMPFIRE programme, each ward could benefit from two land uses – agriculture and wildlife. The ward must make a choice on land uses, in other words how much land to allocate to wildlife and how much to agriculture. When a hunting area belongs to one ward, the outcome is desirable; whereas if it belongs to two wards, it becomes complicated. We modelled the two scenarios: Scenario 1 – hunting area belonging to one ward; and Scenario 2 – hunting area shared by two wards. We used Pontryagin’s maximum principle to solve the models analytically and to carry out comparative statics. We also applied the results to the study areas using secondary data. The results from the analysis suggest that there is a need to make it mandatory for communities who bear the cost of wildlife management to share in the revenue from wildlife.
Prediction of a Mobile Solid State in Dense Hydrogen under High Pressures
Creators: name: Geng, Hua Y.
name: Wu, Q.
name: Sun, Y.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Solid rigidity and liquid-scale mobility are thought incompatible in elemental substances. One cannot have an elemental solid that is long-range positionally ordered wherein the atoms flow like in a liquid simultaneously. The only exception might be the hypothetical supersolid state of 4He. In this work, we demonstrate that such exotic state could exist even in the classical regime. Using ab initio molecular dynamics (AIMD) and ab initio path integral molecular dynamics (AI-PIMD), a novel state of dense hydrogen which simultaneously has both long-range spatial ordering and liquid-scale atomic mobility is discovered at 1~1.5 TPa (1 TPa=10000000 atmospheric pressures). The features distinct from a normal solid and liquid are carefully characterized, with the stability and melting behavior are investigated. Extensive AI-PIMD simulations further revealed that this state might be (meta-)stable even at ultra-low temperatures, suggesting an emerging candidate for an alternative type of supersolid state in dense metallic hydrogen.
description: 26 pages, 9 figures
From Fixed-X to Random-X Regression: Bias-Variance Decompositions, Covariance Penalties, and Prediction Error Estimation
Creators: name: Saharon Rosset
name: Tibshirani, Ryan J.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: In statistical prediction, classical approaches for model selection and model evaluation based on covariance penalties are still widely used. Most of the literature on this topic is based on what we call the “Fixed-X” assumption, where covariate values are assumed to be nonrandom. By contrast, it is often more reasonable to take a “Random-X” view, where the covariate values are independently drawn for both training and prediction. To study the applicability of covariance penalties in this setting, we propose a decomposition of Random-X prediction error in which the randomness in the covariates contributes to both the bias and variance components. This decomposition is general, but we concentrate on the fundamental case of ordinary least squares (OLS) regression. We prove that in this setting the move from Fixed-X to Random-X prediction results in an increase in both bias and variance. When the covariates are normally distributed and the linear model is unbiased, all terms in this decomposition are explicitly computable, which yields an extension of Mallows' Cp that we call RCp. RCp also holds asymptotically for certain classes of nonnormal covariates. When the noise variance is unknown, plugging in the usual unbiased estimate leads to an approach that we call RCp ^, which is closely related to Sp (Tukey, 1967), and GCV (Craven and Wahba, 1978). For excess bias, we propose an estimate based on the “shortcut-formula” for ordinary cross-validation (OCV), resulting in an approach we call RCp+. Theoretical arguments and numerical simulations suggest that RCp+ is typically superior to OCV, though the difference is small. We further examine the Random-X error of other popular estimators. The surprising result we get for ridge regression is that, in the heavily-regularized regime, Random-X variance is smaller than Fixed-X variance, which can lead to smaller overall Random-X error.