cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Correlates of receiving recommended adolescent vaccines among adolescent females in North Carolina
Creators: name: McRee, Annie-Laurie
name: Gottlieb, Sami
name: Brewer, Noel
name: Reiter, Paul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Background: Immunization is a successful and cost-effective method for preventing disease, yet many adolescents do not receive recommended vaccines. We assessed correlates of uptake of three vaccines (tetanus booster, meningococcal and human papillomavirus [HPV] vaccines) recommended for adolescent females. Results: Only 17% of parents indicated their daughters had received all three vaccines. Eighty-seven percent of parents indicated their daughters had received tetanus booster vaccine, 36% reported vaccination against meningococcal disease and 36% reported HPV vaccine initiation. Daughters aged 13–15 years (OR = 1.70, 95% CI: 1.09–2.64) or 16–20 years (OR = 2.28, 95% CI: 1.51–3.44) had received a greater number of these vaccines compared to daughters aged 11–12 years. Daughters who had preventive care visits in the last year (OR = 4.81, 95% CI: 3.14–7.34) or whose parents had at least some college education (OR = 1.90, 95% CI: 1.29–2.80) had also received a greater number of these vaccines. Methods: We examined cross-sectional data from 647 parents of 11–20 year-old females from North Carolina who completed the Carolina HPV Immunization Measurement and Evaluation (CHIME) Project follow-up survey in late 2008. Analyses used ordinal and binary logistic regression. Conclusions: Few daughters, particularly 11–12 years olds, had received all three vaccines recommended for adolescent females. Ensuring annual preventive care visits and increasing concomitant administration of adolescent vaccines may help increase vaccine coverage.
Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes
Creators: name: Johnson, Mark
name: Wang, Bo
name: Tisch, Roland
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting in the destruction of the insulin-secreting β cells. Currently, there is no established clinical approach to effectively suppress long-term the diabetogenic response. Genetic-based vaccination offers a general strategy to reestablish β cell-specific tolerance within the T cell compartment. The transfer of genes encoding β cell autoantigens, anti-inflammatory cytokines and/or immunomodulatory proteins has proven to be effective at preventing and suppressing the diabetogenic response in animal models of T1D. The current review will discuss genetic approaches to prevent and treat T1D with an emphasis on plasmid DNA- and adeno-associated virus-based vaccines.
The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers
Creators: name: Solinga, R. M.
name: Moss, N. G.
name: Zimmer, D. P.
name: Riguera, D. A.
name: Currie, M. G.
name: Goy, M. F.
name: Kessler, M. M.
name: Arendshorst, W. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The peptide uroguanylin regulates electrolyte transport in the intestine and kidney. Human uroguanylin has two conformations that can be stably isolated, owing to their slow interconversion rate. The A isomer potently activates the guanylate cyclase-C receptor found primarily in the intestine. The B isomer, by contrast, is a very weak agonist of this receptor, leading to a widely-held assumption that it is physiologically irrelevant. We show here, however, that human uroguanylin B has potent natriuretic activity in the kidney. Interestingly, uroguanylin A and B both induce saliuretic responses, but the activity profiles for the two peptides differ markedly. The uroguanylin B dose-response curve is sigmoidal with a threshold dose near 10 nmol/kg body weight, whereas uroguanylin A has a comparable threshold, but a bell-shaped dose-response curve. Additionally, our study indicates a unique interplay between the A and B isoforms, such that the A form at high concentrations antagonizes the natriuretic action of the B form. These data show that the kidney contains a uroguanylin receptor whose pharmacological profile does not match that of the well-defined intestinal uroguanylin receptor (guanylate cyclase-C), an observation consistent with previous studies showing that the kidney of the guanylate cyclase-C knockout mouse remains responsive to uroguanylin. The results presented here also support the unconventional notion that distinct conformations of a single endocrine peptide can elicit different responses in different tissues.
MPEC 2023-F30 : DAILY ORBIT UPDATE (2023 March 18)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
(190) James Nisbet McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(187) Agnes Jane McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(191) Janet Frances McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Teilhabe in sozialen Netzwerken von Menschen mit psychischer Beeinträchtigung unter den Bedingungen der COVID-19-Pandemie
Creators: name: Sellmeyer, Judith
Publisher: name: Katholische Hochschule Nordrhein-Westfalen, Köln
Year: 2023
Subjects: subject: 300 Sozialwissenschaften

description: In der Forschungsarbeit steht die Lebenssituation von Menschen mit psychischer Beeinträchtigung während der COVID-19-Pandemie im Jahr 2021 im Fokus. Die Forschungsarbeit bildet das subjektive Erleben in und den Umgang mit sozialen Netzwerken hinsichtlich der Teilhabechancen und -barrieren unter den Bedingungen der COVID-19-Pandemie ab. Mittels einer qualitativen Erhebung und dem zusätzlichen Einsatz von Netzwerkanalysen wird sich mit Teilhabemöglichkeiten in sozialen Netzwerken auseinandergesetzt.
description: Institut für Teilhabeforschung: Schriftenreihe; 2
การพัฒนาฟิล์มย่อยสลายได้จากแป้งมันแกวเพื่อประยุกต์ใช้เป็นถุงเพาะชำ
Creators: name: ภาวิณี เทียมดี
Publisher: name: มหาวิทยาลัยราชภัฏเทพสตรี
Year: 2020
Subjects: แป้งมันแกว
ฟิล์มย่อยสลายได้
กลีเซอรอล
พลาสติกไซเซอร์

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 14, 1, 1-14
Multi-Object Analysis of Volume, Pose, and Shape Using Statistical Discrimination
Creators: name: Gerig, G.
name: Marron, J.S.
name: Hazlett, H.C.
name: Piven, J.
name: Gorczowski, K.
name: Styner, M.
name: Jeong, J.Y.
name: Pizer, S.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: One goal of statistical shape analysis is the discrimination between two populations of objects. Whereas traditional shape analysis was mostly concerned with studying single objects, analysis of multi-object complexes presents new challenges related to alignment and relative object pose. In this paper, we present a methodology for discriminant analysis of sets multiple shapes. Shapes are represented by sampled medial manifolds including normals to the boundary. Non-Euclidean metrics that describe geodesic distance between sets of sampled representations are used for shape alignment and discrimination. Our choice of discriminant method is the distance weighted discriminant (DWD) because of its generalization ability in high dimensional, low sample size settings. Using an unbiased, soft discrimination score we can associate a statistical hypothesis test with the discrimination results. Furthermore, localization and nature significant differences between populations can be visualized via the average best discriminating axis.
(184) Arabella Cargill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(186) Louisa Stewart McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Phase transition in the exit boundary problem for random walks on groups
Creators: name: Vershik, A.
name: Malyutin, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 31C35, 60J50, 82B26

description: We describe the full exit boundary of random walks on homogeneous trees, in particular, on the free groups. This model exhibits a phase transition, namely, the family of Markov measures under study loses ergodicity as a parameter of the random walk changes. The problem under consideration is a special case of the problem of describing the invariant (central) measures on branching graphs, which covers a number of problems in combinatorics, representation theory, probability and was fully stated in a series of recent papers by the first author \cite{V1,V2,V3}. On the other hand, in the context of the theory of Markov processes, close problems were discussed as early as 1960s by E.~B.~Dynkin.
description: 15 pp.Ref.19
Relationship of complement to experimental arthritis induced in rats with streptococcal cell walls.
Creators: name: Anderle, S.K.
name: Allen, J.B.
name: Eisenberg, R.
name: Cromartie, W.J.
name: Schwab, J.H.
name: Dalldorf, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1982

description: Experimental arthritis developed in rats injected intraperitoneally with aqueous suspensions of peptidoglycan-polysaccharide complexes (PG-APS) isolated from group A streptococcal cell walls. Reduction of serum complement by pretreatment with cobra venom factor (COV) reduced acute joint inflammation over the first 3 days following injection of PG-APs. Thereafter, the course of the disease was not different in the COV-treated rats. The serum levels of complement were depressed below detectable levels by 24 hr in rats injected only with cell walls, but rebounded to normal levels or above 3 days after injection. In rats injected with COV before cell walls, the complement levels also increased 3 days after injection of cell walls, in contrast to sustained depressed levels in rat injected only with COV. The correlation between severity of joint inflammation and serum complement levels at day 3 was positive in COV-treated rats. The quantity of cell wall per joint at day 3 correlated with the severity of joint disease. However, COV treatment did not alter the amount of cell wall localized in joint tissue. Therefore, although complement does appear to have a role in early joint inflammation, its effect is not upon the transport of cell wall into joint tissue.
ความคาดหวังของผู้ประกอบการที่มีต่อคุณลักษณะของบัณฑิตที่พึงประสงค์ในยุคฐานวิถีชีวิตใหม่
Creators: name: เทพรัตน์ เอื้อธรรมถาวร
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: ความคาดหวัง
ผู้ประกอบการ
คุณลักษณะบัณฑิตที่พึงประสงค์

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 1, 1-8
Cell cycle control of a Burkitt lymphoma cell line: responsiveness to growth signals engaging the C3D/EBV receptor.
Creators: name: Böck, G.
name: Petzer, A.L.
name: Eigentler, A.
name: Hosp, M.
name: Myones, B.L.
name: Dierich, M.P.
name: Pernegger, G.
name: Wick, G.
name: Schulz, T.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: CR2, the receptor for the C3d fragment of the third complement component and for Epstein-Barr virus (EBV) has been shown, on mouse B cells, to be involved in the control of B-cell proliferation by acting as a receptor for macrophage-derived growth factors. We examined whether the growth of a Burkitt lymphoma cell line, RAJI, could be influenced by ligands of human CR2. In serum-free culture, purified human C3d, as well as three monoclonal antibodies to distinct epitopes on human CR2, were capable of enhancing the growth rate of RAJI cells two to five-fold. This effect could not be observed if even trace amounts of serum were present in the culture medium. Simultaneous addition of pairs of antibodies did not enhance the growth rate, suggesting that a particular engagement of CR2 may be critical in order to induce a stimulatory effect. These results indicate that in a homologous serum-free human B-cell system human C3d as well as monoclonal antibodies to human CR2 can induce B-cell proliferation and that CR2-mediated triggering of B cells can be induced via epitopes other than the C3d-binding site. In addition we conclude that--unlike normal human B cells--at least some human B-lymphoma cells respond to CR2-mediated stimuli in the absence of any T-cell derived factors. Therefore the control mechanisms exerted through CR2 must still be intact on these autonomously growing cells.
Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice.
Creators: name: Pisetsky, D.S.
name: Shores, E.W.
name: Cohen, P.L.
name: Eisenberg, R.A.
name: Grudier, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1988

description: The spontaneous occurrence of antibodies against the Sm nuclear antigen is a highly specific marker for the diagnosis of SLE. We have previously shown that anti-Sm can be elicited by immunization of SLE-prone mice with purified Sm antigen. In the present study, this autoantibody was induced in normal mice by a similar immunization protocol. Anti-Sm produced by normal strains was predominantly IgG1, which is similar to the isotype distribution in Sm-immunized MRL mice, but unlike the IgG2a-dominated response seen for spontaneous anti-Sm. Anti-Sm raised by immunization in most strains recognized epitopes not seen by spontaneous human and murine SLE anti-Sm; of the eleven normal strains tested, only C3H and AKR, strains from which MRL was partially derived, responded to these determinants. Further, immunoblot analysis of anti-Sm generated by immunization of MRL and normal mice revealed that the same proteins recognized by spontaneous human and murine anti-Sm were also seen by these sera. This study shows that an autoantibody highly characteristic of SLE can be produced in normal and MRL mice after appropriate immunization, and that the fine specificity of such experimentally induced antibody can be similar to that of spontaneous anti-Sm autoantibodies. The results imply a role for autoimmunization with Sm in the production of anti-Sm.
Energy, momentum and angular momentum conservations in de Sitter gravity
Creators: name: Lu, Jia-An
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In de Sitter (dS) gravity, where gravity is a gauge field introduced to realize the local dS invariance of the matter field, two kinds of conservation laws are derived. The first kind is a differential equation for a dS-covariant current, which unites the canonical energy-momentum (EM) and angular momentum (AM) tensors. The second kind presents a dS-invariant current which is conserved in the sense that its torsion-free divergence vanishes. The dS-invariant current unites the total (matter plus gravity) EM and AM currents. It is well known that the AM current contains an inherent part, called the spin current. Here it is shown that the EM tensor also contains an inherent part, which might be observed by its contribution to the deviation of the dust particle's world line from a geodesic. All the results are compared to the ordinary Lorentz gravity.
description: 13 pages, title changed
Generation of a T-cell hybridoma producing a contrasuppressor factor for contact sensitivity.
Creators: name: Reuter, P.A.
name: Flood, P.M.
name: Green, D.R.
name: Friedman, A.M.
name: Ptak, W.
name: Brewer, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: C3H/HeN mice were immunized to induce contrasuppressor T-cell (Tcs) activity, splenic T cells from these mice were fused with the BW5147 thymoma, and the resulting hybridomas were tested for their ability to produce a contrasuppressor T-cell factor (TcsF). Nine TcsF-producing hybridomas were preliminarily identified by their ability to inhibit the effect of antigen-specific suppressor T-cell factor (TsF) on the adoptive transfer of contact sensitivity. One of these hybrids, AF5.C6, was cloned, the production of a contrasuppressor factor confirmed, and the high-titred TcsF produced by this cloned hybrid characterized. Hybridoma-derived TcsF is antigen-specific and specifically binds its antigen, but does not bear immunoglobulin (Ig) determinants. Thus, hybridoma-derived TcsF is serologically and functionally identical to an antigen-specific contrasuppressor factor for contact sensitivity, whose production from splenocyte cell cultures has previously been described. The generation of a hybridoma secreting a contrasuppressor factor identical to that produced by spleen cells significantly strengthens the hypothesis that the phenomenon of T-cell contrasuppression is mediated by a specific subset of cells whose activity is contrasuppressive. The further advantages of employing T-cell hybridomas for functional, biochemical and molecular genetic analyses of contrasuppression are also discussed.
เมตาเวิร์สสำหรับการศึกษา: การเชื่อมต่อระหว่างจักรวาลนฤมิตกับโลกความจริงของการเรียนรู้ที่จะก่อให้เกิดการเรียนรู้แบบดื่มด่ำ
Creators: name: สุรพล บุญลือ
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: จักรวาลนฤมิต
เสมือนจริง
ห้องเรียนเสมือนจริง
การเรียนรู้แบบดื่มด่ำ

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 1, 9-16
Targeting of T-B interaction using heteroconjugate antibody.
Creators: name: Cohen, P.L.
name: Davignon, J.L.
name: Eisenberg, R.A.
name: Vallin-Davignon, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: We have deliberately targeted collaboration between T cells and certain B cells by using a heteroconjugate (HETCONJ) antibody. This specific reagent was created by cross-linking the F(ab')2 portions of anti-I-Ab and anti-CD3 monoclonal antibodies. Spleen cells from B6 (I-Ab) but not bm12 (I-Abm12) mice proliferated in vitro in the presence of the HETCONJ. Similarly, T-cell dependent IgM secretion was induced in B cells from B6, yet only weakly in B cells from bm 12 mice. Using B cells from Igh allotype double congenic (B6.C20 Igha/I-Ab and bm12, Ighb/I-Abm12) mice in co-culture experiments, we have used the HETCONJ to study linked versus bystander T-B interaction. B-cell activation, mediated by HETCONJ, was 10 times greater in unseparated than in resting splenic B cells. T-B interaction through T-B contact was more efficient than activation through bystander effects both for unseparated and resting splenic B cells. Large, already activated B cells, in contrast, did not show a preference for linked recognition. Our reagent has mimicked some of the events involved in T-B collaboration and may be useful in studying the molecular basis of cellular interactions.
(188) John McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Two-step build-up of a thermoreversible polymer network: From early local to late collective dynamics
Creators: name: Souguir, H.
name: Ronsin, O.
name: Caroli, C.
name: Baumberger, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We probe the mechanisms at work in the build-up of thermoreversible gel networks, with the help of hybrid gelatin gels containing a controlled density of irreversible, covalent crosslinks (CL), which we quench below the physical gelation temperature. The detailed analysis of the dependence on covalent crosslink density of both the shear modulus and optical activity evolutions with time after quench enables us to identify two stages of the physical gelation process, separated by a temperature dependent crossover modulus: (i) an early nucleation regime during which rearrangements of the triple-helix CL play a negligible role, (ii) a late, logarithmic aging one, which is preserved, though slowed down, in the presence of irreversible CL. We show that aging is fully controlled by rearrangements and discuss the implication of our results in terms of the switch from an early, local dynamics to a late, cooperative long-range one.
Model of THG and EFISH using the SBHM
Creators: name: Alejo-Molina, Adalberto
name: Hingerl., Kurt
name: Hardhienata, Hendradi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report for the first time a comprehensive study of the fourth rank tensor describing third harmonic generation (THG) and electric field induced second harmonic (EFISH) in centrosymmetric material from two different viewpoints: Group Theory (GT) and the Simplified Bond Hyperpolarizability Model (SBHM). We show that the fourth rank tensor related to THG and direct current (DC) EFISH can be reduced to two independent elements whereas SBHM always gives only one, reproducing perfectly well EFISH experimental results in Metal Oxyde Semiconductor (MOS). We argue that it is possible to reduce the fourth rank tensor describing EFISH to a third rank tensor and further deliver a classical explanation of EFISH regarding symmetry breaking where the term containing $r^3$ in the potential immediately leads to second harmonic generation (SHG).
description: 11 pages, 4 figures
การดูดซับสีย้อมเมทิลีนบลูของถ่านเปลือกส้มโอที่เตรียมจากการเผาแบบเตาลาน
Creators: name: พัชรนันท์ จันทร์พลอย
Publisher: name: มหาวิทยาลัยราชภัฏเชียงใหม่
Year: 2020
Subjects: ถ่านเปลือกส้มโอ
การเผาแบบเตาลาน
การดูดซับ
สีย้อมเมทิลบลู

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 14, 1, 15-25
CD4+ cytolytic effectors are inefficient in the clearance of Listeria monocytogenes
Creators: name: WEINSTOCK, D.
name: KURLANDER, R. J.
name: SERODY, J. S.
name: POSTON, R. M.
name: FRELINGER, J. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Cytotoxic T lymphocytes (CTL) recognize and lyse target cells through the interaction of the T-cell receptor complex with the class I or class II major histocompatibility complex (MHC). The production of class I-restricted CTL has been shown to be critical to the elimination of specific pathogens including . However, the function of class II-restricted CTL in the clearance of intracellular pathogens is poorly understood. H-2β-microglobulin-deficient mice (βM−/−) are not able to produce CD8 CTL in response to infection with . We used this model to evaluate the efficacy of class II-restricted CTL, in the absence of a class I-restricted response, during a primary infection with . We demonstrate that, despite their effectiveness in adoptive transfer of protection, -specific CD4 class II-restricted cytotoxic lymphocytes are ineffective in decreasing titres of in the spleen after an established infection. In βM−/− mice, persistence of in the spleen was found preferentially in class II-negative cells. Surprisingly, class I-restricted CTL from C57BL/6 mice were capable of decreasing bacterial titres during an established infection even in the absence of detectable class I on the surface of cells from βM−/− mice. These data strongly suggest that, in the absence of a class I-restricted response, pathogens that elicit a class II-restricted cytotoxic response may escape prompt eradication by the immune system.
SSHOC Workshop: Sharing Datasets of Pathological Speech
Creators: name: Heuvel, Henk Van Den
name: Bessell, Nicola
name: Trilsbeek, Paul
name: Bishop, Libby
name: Klessa, Katarzyna
Publisher: name: Zenodo
Year: 2020
Subjects: SSHOC
Social Sciences and Humanities Open Cloud
European Open Science Cloud
EOSC
Sharing Datasets
Pathological Speech
Corpora

description: Corpora and datasets of pathological speech are hard to get simply because they are hard to share. In this webinar we will present and explore several alternatives for sharing such sensitive data. The webinar is interesting for all who struggle with sharing and obtaining similar types of data. Topics for discussion include: Progress achieved by the DELAD initiative for sharing corpora of speech disorders (CSD) and the role of the CLARIN Knowledge Centre on Atypical Communication Expertise GDPR and the ethics of special category data relevant for collecting and sharing CSD How storing and sharing CSD is arranged in a GDPR compliant way at the Language Archive of the Max Plank Institute for Psycholinguistics and the collaboration with the Talkbank at CMU Infrastructure requirements for secure remote access to sensitive research data with diverse legal (e.g. social media terms of service), ethical (e.g. children as subjects), and technical (e.g. audio and video) challenges, and assessment of several existing platforms The CAVA audio-visual human communication archive project - a digital video repository to support the work of the international human communication research community. This resource enhances the discoverability and re-usability of expensively-created, specialist video content The curation and disclosure of pathological speech corpora: how CSD can be found through one organisation and made accessible through another - includes a demonstration using the example of the Polish Cued Speech Corpus of Hearing-Impaired Children
Interfacial undercooling in the solidification of colloidal suspensions-analyses with quantitative measurements
Creators: name: You, Jiaxue
name: Wang, Lilin
name: Wang, Zhijun
name: Li, Junjie
name: Wang, Jincheng
name: Lin, Xin
name: Huang, Weidong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Interfacial undercooling is of significant importance on microscopic pattern formation in the solidification of colloidal suspensions. Two kinds of interfacial undercooling are supposed to be involved in freezing colloidal suspensions, i.e. solute constitutional supercooling (SCS) caused by additives in the solvent and particulate constitutional supercooling (PCS) caused by particles. However, quantitatively identification of the interfacial undercooling of freezing colloidal suspensions is still absent and it is still unknown which undercooling is dominant. The revealing of interfacial undercooling is closely related to the design of ice-templating porous materials. Based on quantitative experimental measurements, we show that the interfacial undercooling mainly comes from SCS caused by the additives in the solvent, while the PCS can be ignored. This finding implies that the PCS theory is not the fundamental physical mechanism for patterning in the solidification of colloidal suspensions. Instead, the patterns in ice-templating method can be controlled effectively by adjusting the additives.
description: 7 pages, 9 figures, 2 tables, 1 movie
ผลกระทบและส่วนผสมที่เหมาะสมของผงเปลือกมังคุดสำหรับแบบหล่อทรายชื้น
Creators: name: อนุวิทย์ สนศิริ
Publisher: name: มหาวิทยาลัยเทคโนโลยีราชมงคลกรุงเทพ
Year: 2020
Subjects: แบบหล่อทรายชื้น
ผงเปลือกมังคุด
ออกแบบการทดลอง
การผลิต

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 14, 1, 26-36
Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis
Creators: name: Qian, Bi-Feng
name: Sartor, R. Balfour
name: Hoentjen, Frank
name: Tonkonogy, Susan
name: Dieleman, Levinus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: HLA-B27/β2 microglobulin transgenic (TG) rats spontaneously develop T-cell-mediated colitis when colonized with normal commensal bacteria, but remain disease-free under germ-free conditions. We investigated regulation of in vitro T-cell responses to enteric bacterial components. Bacterial lysates prepared from the caecal contents of specific pathogen-free (SPF) rats stimulated interferon-γ (IFN-γ) production by TG but not non-TG mesenteric lymph node (MLN) cells. In contrast, essentially equivalent amounts of interleukin-10 (IL-10) were produced by TG and non-TG cells. However, when cells from MLNs of non-TG rats were cocultured with TG MLN cells, no suppression of IFN-γ production was noted. Both non-TG and TG antigen-presenting cells (APC) pulsed with caecal bacterial lysate were able to induce IFN-γ production by TG CD4+ cells, although non-TG APC were more efficient than TG APC. Interestingly, the addition of exogenous IL-10 inhibited non-TG APC but not TG APC stimulation of IFN-γ production by cocultured TG CD4+ lymphocytes. Conversely, in the presence of exogenous IFN-γ, production of IL-10 was significantly lower in the supernatants of TG compared to non-TG APC cultures. We conclude that commensal luminal bacterial components induce exaggerated in vitro IFN-γ responses in HLA-B27 TG T cells, which may in turn inhibit the production of regulatory molecules, such as IL-10. Alterations in the production of IFN-γ, and in responses to this cytokine, as well as possible resistance of TG cells to suppressive regulation could together contribute to the development of chronic colitis in TG rats.
Whittaker S, Arguing for Adaptation, Routledge Green Finance Handbook, Supplementary Files
Creators: name: Whittaker, Stella
Publisher: name: Zenodo
Year: 2023
Subjects: climate adaptation
climate change
climate resilience
urban adaptation
climate finance
green finance
adaptation gap

description: These Supplementary Files support the analysis described in the published paper: Arguing for climate change adaptation finance – A bibliometric study in the Routledge Green Finance Handbook. They contain items S1 to S7 which are referenced in the main paper. The analysis is the author’s own work and originates from the literature extracted for the Systematic Literature Review and bibliometric analysis undertaken by the author in 2021. The analysis supplements the findings presented in the paper. Original data can be made available upon request to the author.
Memory CD8+ T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production
Creators: name: Maile, Robert
name: Kerry, Samantha
name: Frelinger, Jeffrey
name: Collins, Edward
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Memory T-cell responses are faster and more robust than those of their naïve counterparts. The mechanisms by which memory T cells respond better to subsequent antigenic exposure remain unresolved. A portion of the more rapid response is undoubtedly the result of the increased frequency of antigen-specific cells. In addition, there are also differences in the cells themselves with respect to their requirements for costimulation and the apparent avidity of the T cells. We used major histocompatibility complex (MHC) class I tetramers to stimulate T cells to focus on the interaction of T-cell receptor (TCR)/MHC and CD8 in the absence of other molecules that are present on cell surfaces and so contribute to the activation of T cells by undefined mechanisms. Mutated MHC class I tetramers that are unable to engage CD8 were used to investigate the role of CD8 engagement in memory cell activation. Either wild-type tetramers or tetramers carrying the mutation were used to stimulate both memory and naïve TCR transgenic T cells in vitro. Surprisingly, like naïve cells, memory CD8+ T cells required CD8 engagement for calcium mobilization and optimum proliferation. In contrast, the requirements for cytokine production differed. Unlike naive cells, memory cells were able to produce cytokine in the absence of CD8 engagement. This suggests both a CD8-dependent pathway for early events and a CD8-independent pathway for cytokine production in memory cells.
(185) Robert Cargill McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells
Creators: name: Jobin, Christian
name: Kim, Joo Sung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The nuclear factor (NF)-κB transcriptional system is a major effector pathway involved in inflammation and innate immune responses. The flavonoid luteolin is found in various herbal extracts and has shown anti-inflammatory properties. However, the mechanism of action and impact of luteolin on innate immunity is still unknown. We report that luteolin significantly blocks lipopolysaccharide (LPS)-induced IκB phosphorylation/degradation, NF-κB transcriptional activity and intercellular adhesion molecule-1 (ICAM-1) gene expression in rat IEC-18 cells. Using chromatin immunoprecipitation, we demonstrate that LPS-induced RelA recruitment to the ICAM-1 gene promoter is significantly reduced in luteolin-treated cells. Moreover, in vitro kinase assays show that luteolin directly inhibits LPS-induced IκB kinase (IKK) activity in IEC-18 cells. Using bone-marrow derived dendritic cells (BMDCs) isolated from interleukin (IL)-10−/− mice or from recently engineered transgenic mice expressing the enhanced green fluorescent protein (EGFP) under the transcriptional control of NF-κB cis-elements (cis-NF-κBEGFP), we found that luteolin blocks LPS-induced IκB phosphorylation and IKK activity, and decreases EGFP, IL-12 and tumour necrosis factor-α gene expression. Moreover, intraperitoneal administration of luteolin significantly inhibited LPS-induced EGFP expression in both peripheral blood mononuclear cells and splenocytes isolated from cis-NF-κBEGFP mice. These results indicate that luteolin blocks LPS-induced NF-κB signalling and proinflammatory gene expression in intestinal epithelial cells and dendritic cells. Modulation of innate immunity by natural plant products may represent an attractive strategy to prevent intestinal inflammation associated with dysregulated innate immune responses.
การพัฒนาคุณภาพการบริการของโรงแรมในกลุ่มจังหวัดร้อยเอ็ดเพื่อรองรับนักท่องเที่ยว
Creators: name: กนกวรรณกรณ์ หลวงวังโพธิ์
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: คุณภาพการบริการ
คุณภาพการบริการที่คาดหวัง
นักท่องเที่ยว
โรงแรม

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 1, 24-38
title:  I: International Co-operative Law
Creators: name: Fajardo-García  , Gemma
Publisher: name: Roma TrE-Press
Year: 2016

description: Co-operative Law has a long tradition in European countries, like the Industrial and Provident Act in the United Kingdom in1852 or the Prussian Co-operatives Act in 1867. The European Union was no born to create a common law but to remove restrictions on the freedom of establishment. In 2003 the Statute for a European Co-operative Society was approved, but harmonization of European co-operative legislation was never carried out, not even for its most importante distinctive elements. In 2012 the European Commission presented a report about the application of the SCE Statute showing that the SCE Regulation has had relatively little success. The differences between the different legal systems are considerable, both in forma and in content. European Commission expressed its intention not to carry out the harmonization of the European co-operative legislation directly, but to support the harmonization proposals that the co-operative sector presented to it.

El derecho cooperativo tiene una larga tradición en los países europeos, desde la Industrial and Provident Act de 1952 en Reino Unido o la Ley prusiana de cooperativas de 1867. La Unión Europea no nació para crear un derecho común sino para surprimir las restricciones a la libertad de establecimiento. In 2003 se aprobó el Estatuto de la Sociedad Cooperativa Europea, pero nunca se ha llevado a cabo una armonización de la legislación cooperativa en Europa, ni siquiera en relación con sus elementos más característicos. En 2012, la Comisión Europea presentó un informe sobre la aplicación del Estatuto de la SCE que mostraba que esta regulación había tenido relativamente poco éxito. Las diferencias entre los diferentes sistemas legales son considerables, tanto formalmente como por su contenido. La Comisión Europea ya manifestó su intención de no llevar a cabo la armonización de la legislación cooperativa europea directamente, pero sí apoyar las propuestas de armonización presentadas por el sector cooperativo.
description: The co-operative firm. Keywords
A meta-analysis on the effectiveness of anthropomorphism in human-robot interaction
Creators: name: Roesler, Eileen
name: Manzey, Dietrich
name: Onnasch, Linda
Publisher: name: Technische Universität Berlin
Year: 2021
Subjects: subject: 600 Technik, Technologie
subject: anthropomorphism
subject: human-robot interaction
subject: design

description: The application of anthropomorphic design features is widely assumed to facilitate human-robot interaction (HRI). However, a considerable number of study results point in the opposite direction. There is currently no comprehensive common ground on the circumstances under which anthropomorphism promotes interaction with robots. Our meta-analysis aims to close this gap. A total of 4856 abstracts were scanned. After an extensive evaluation, 78 studies involving around 6000 participants and 187 effect sizes were included in this meta-analysis. The majority of the studies addressed effects on perceptual aspects of robots. In addition, effects on attitudinal, affective, and behavioral aspects were also investigated. Overall, a medium positive effect size was found, indicating a beneficial effect of anthropomorphic design features on human-related outcomes. However, closer scrutiny of the lowest variable level revealed no positive effect for perceived safety, empathy, and task performance. Moreover, the analysis suggests that positive effects of anthropomorphism depend heavily on various moderators. For example, anthropomorphism was in contrast to other fields of application, constantly facilitating social HRI. The results of this analysis provide insights into how design features can be used to improve the quality of HRI. Moreover, they reveal areas in which more research is needed before any clear conclusions about the effects of anthropomorphic robot design can be drawn.
Luminal bacterial antigen-specific CD4+ T-cell responses in HLA-B27 transgenic rats with chronic colitis are mediated by both major histocompatibility class II and HLA-B27 molecules
Creators: name: Tonkonogy, Susan
name: Balfour Sartor, R.
name: Qian, Bi-Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Rats transgenic (TG) for the human major histocompatibility complex (MHC) class I HLA-B27 and β2-microglobulin genes develop chronic colitis under specific pathogen-free (SPF) but not sterile (germ-free, GF) conditions. We investigated the role of antigen-presenting molecules involved in generating immune responses by CD4+ mesenteric lymph node (MLN) cells from colitic HLA-B27 TG rats to commensal enteric micro-organisms. All TG MLN cells expressed HLA-B27. A higher level of MHC class II was expressed on cells from TG rats, both SPF and GF, compared to non-TG littermates. In contrast, rat MHC class I expression was lower on TG than non-TG cells. Both TG and non-TG antigen presenting cells (APC) pulsed with caecal bacterial antigens induced a marked interferon-γ (IFN-γ) response in TG CD4+ T lymphocytes but failed to stimulate non-TG cells. Blocking MHC class II on both TG and non-TG APC dramatically inhibited their ability to induce TG CD4+ T cells to produce IFN-γ. Blocking HLA-B27 on TG APC similarly inhibited IFN-γ responses. When the antibodies against MHC class II and HLA-B27 were combined, no APC-dependent IFN-γ response was detected. These data implicate both native rat MHC class II and TG HLA-B27 in CD4+ MLN T-cell IFN-γ responses to commensal enteric microflora in this colitis model.
ผลการใช้ชุดกิจกรรมแนะแนวแบบออนไลน์ตามแนวทฤษฎีพิจารณาเหตุผล อารมณ์ และพฤติกรรมเพื่อพัฒนากรอบความคิดแบบเติบโตด้านการเรียนของนักเรียนระดับชั้นมัธยมศึกษาปีที่ 1 - 3 ในจังหวัดพระนครศรีอยุธยา
Creators: name: กัญญาวีร์ พิมพิสนธิ์
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: ชุดกิจกรรมแนะแนวแบบออนไลน์
กรอบความคิดแบบเติบโต
ทฤษฎีพิจารณาเหตุผล อารมณ์และพฤติกรรม
สำนักงานเขตพื้นที่การศึกษามัธยมศึกษา เขต 31

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 1, 39-49
Single-Cell Proteomics using Ultrahigh-Resolution Mass Spectrometry to Unravel Cellular Heterogeneity in Complex Tissues
Creators: name: Olukotun, Ibukunoluwa Fikayo
Publisher: name: Zenodo
Year: 2025

description: Understanding cellular heterogeneity is critical for deciphering the complexity of biological systems, disease mechanisms, and therapeutic responses. Traditional bulk proteomics, while valuable, masks the diversity among individual cells by averaging protein expression profiles across heterogeneous populations. This limitation impedes insights into rare cell types, transient cell states, and functional subpopulations within complex tissues such as tumors, the brain, and the immune system. The emergence of single-cell proteomics (SCP) offers a transformative approach to profile proteins at single-cell resolution, thereby enabling high-definition molecular phenotyping. Ultrahigh-resolution mass spectrometry (UHR-MS) has emerged as a pivotal technology in advancing SCP by allowing the detection of low-abundance proteins, resolving isobaric species, and improving the dynamic range of quantification. Recent innovations in sample preparation, including nanodroplet processing, ultra-low-flow liquid chromatography, and ion mobility spectrometry, have significantly enhanced proteome coverage and reproducibility in single-cell analyses. These advances now permit the quantification of thousands of proteins per cell, shedding light on functional diversity that underpins tissue organization and disease progression. This study highlights the integration of UHR-MS in SCP workflows to dissect cellular heterogeneity in complex tissues. We explore its application in profiling immune cell subtypes in inflamed tissues, mapping cancer cell plasticity, and tracking lineage-specific proteomic signatures in neurodevelopment. The review also discusses current challenges such as throughput, sensitivity, and data interpretation, and presents future directions, including machine learning-assisted analysis and multiplexed approaches. Single-cell proteomics powered by UHR-MS stands poised to redefine our understanding of cell biology in health and disease.