cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title:  La pratica del counseling
Creators: name: Turco, Benedetta
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2024

description: La pratica del counseling, indagata tramite una ricerca sociologica, ci pone di fronte ad una professione che si basa sull’empatia, sull’accoglienza, sulla relazione d’aiuto nella quale sono coinvolti i counselor (61 intervistate/i) e i clienti, ovvero chi ha bisogno di sostegno, di ascolto (attivo), di accompagnamento verso un obiettivo da raggiungere tramite le proprie risorse individuali. Inoltre, nel percorso di counseling dei professionisti intervistati tra novembre 2023 e febbraio 2024 l’attenzione è volta sulla capacità del cliente di guardare alle proprie difficoltà e incertezze in modo nuovo, puntando sugli aspetti positivi e su quanto è in grado di fare. In questa relazione d’aiuto il cliente – che può essere una singola persona, una coppia, una famiglia, un gruppo, una organizzazione – cerca di prendere coscienza delle proprie emozioni e di ciò di cui ha bisogno per potersi incamminare verso il cambiamento. Per fare ciò, i counselor hanno utilizzato differenti approcci che possono variare in base al tipo di cliente che chiede aiuto cercando, quindi, di comprendere quali tecniche possono essere in grado di favorire il percorso di crescita. In tale scelta si inseriscono anche le attitudini e le abilità dei professionisti considerati che possono integrare ciò che hanno acquisito durante la sua formazione con le proprie esperienze che personalizzano la relazione d’aiuto.

The practice of counseling, investigated through sociological research, presents us with a profession that is based on empathy, on acceptance, on the helping relationship in which the counselors (61 interviewees) and the clients are involved, that is those who need support, (active) listening, accompaniment towards an objective to be achieved through their individual resources. Furthermore, in the counseling process of the professionals interviewed between November 2023 and February 2024, the focus is on the client's ability to look at their difficulties and uncertainties in a new way, focusing on the positive aspects and what they are able to do. In this helping relationship the client - who can be a single person, a couple, a family, a group, an organization - tries to become aware of his emotions and what he needs to be able to move towards change. To do this, counselors have used different approaches which can vary based on the type of client asking for help, therefore trying to understand which techniques may be able to promote the growth path. This choice also includes the attitudes and skills of the professionals considered who can integrate what they have acquired during their training with their own experiences that personalize the helping relationship.
description: La cultura del counseling e il counselor REICO. Una prima ricerca sociologica sul panorama italiano
Additional file 4 of Predominance of low pathogenic avian influenza virus H9N2 in the respiratory co-infections in broilers in Tunisia: a longitudinal field study, 2018–2020
Creators: name: Jbenyeni, Adam
name: Croville, Guillaume
name: Cazaban, Christophe
name: Guérin, Jean-Luc
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 4: GenBank accession numbers of nucleotide sequences generated during this study. Virus sequences generated in this study were submitted to GenBank database under the accession numbers listed in this additional file.
Additional file 1 of Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis
Creators: name: Zhou, Ting
name: lin, Lan
name: Zhan, Yawen
name: Zhang, Ziyao
name: Jiang, Ying
name: Wu, Mi
name: Xue, Dan
name: Chen, Limin
name: Weng, Xiufang
name: Huang, Zhenghui
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1: Figure S1: a Heatmap showing correlation between core enriched genes expression of chemokine signaling pathway and TGFB1 gene expression. b Plots showing Gating strategy of F4/80 + macrophages. c Plots showing Gating strategy of conventional T cells.
Supplementary Material - Supplemental material for Long-Term Multiple Center Experience in Treating Plaque Psoriasis With Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion
Creators: name: Abduelmula, Abrahim
name: Gooderham, Melinda J.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Medicine

description: Supplemental material, Supplementary Material, for Long-Term Multiple Center Experience in Treating Plaque Psoriasis With Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion by Abrahim Abduelmula and Melinda J. Gooderham in Journal of Cutaneous Medicine and Surgery
Sequential topological complexity of aspherical spaces and sectional categories of subgroup inclusions
Creators: name: Espinosa Baro, Arturo
name: Farber, Michael
name: Mescher, Stephan
name: Oprea, John
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 510

description: We generalize results from topological robotics on the topological complexity (TC) of aspherical spaces to sectional categories of fibrations inducing subgroup inclusions on the level of fundamental groups. In doing so, we establish new lower bounds on sequential TCs of aspherical spaces as well as the parametrized TC of epimorphisms. Moreover, we generalize the Costa–Farber canonical class for TC to classes for sequential TCs and explore their properties. We combine them with the results on sequential TCs of aspherical spaces to obtain results on spaces that are not necessarily aspherical.
Bt GENETICS EFFECT ON CORN HYBRID PERFORMANCE: A COMPARISON OF TWO NEAR ISOLINE CORN HYBRIDS
Creators: name: Thorne, Louis
Publisher: name: Digital Repository at the University of Maryland
Year: 2018
Subjects: subject: Agriculture
subject: Bt
subject: Corn Hybrid
subject: near isolines

description: Most corn (Zea mays L.) hybrids planted in the U.S. are the result of genetic modification that gives them a Bt gene or genes obtained from the bacterium, Bacillus thuringiensis (Berliner) (Bt), that express insecticidal proteins and enables these hybrids to be resistant to several insects. European corn borer (ECB) (Ostrinia nubilalis, Hübner) is the main Lepidopteran pest targeted by the Bt corn technology. All Bt events used in current corn hybrids provide 100% control of ECB. This has led to widespread use of Bt hybrids and has resulted in a drastic decrease in the ECB population. This raises the question whether it is still economically feasible to plant Bt hybrids that have higher seed costs in environments where the ECB pest level is low. The objectives of this study were: 1) compare the yield and agronomic performance of a pair of corn near-isoline hybrids with and without the ¬Bt traits; and 2) evaluate the agronomic and economic optimums for yield and nitrogen (N) rate for each near-isoline hybrids. A two-year study at three University of Maryland research farms in 2013-2014 examined each hybrid type for stalk damage due to ECB, yield performance, the optimum N rate for maximizing yield, and the economic returns the two hybrids provided. This study found minimal ECB stalk damage and no consistent agronomic or economic yield difference between the Bt and non-Bt hybrids. Neither hybrid type was determined to have a consistent nitrogen use efficiency (NUE) advantage.  The results of this study indicate that producers should not have concerns over hybrid type choice, now that there is significant regional suppression of ECB below economic levels.
Exact dimension reduction for rough differential equations
Creators: name: Redmann, Martin
name: Riedel, Sebastian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 510

description: In this paper, practically computable low-order approximations of potentially high-dimensional differential equations driven by geometric rough paths are proposed and investigated. In particular, equations are studied that cover the linear setting, but we allow for a certain type of dissipative nonlinearity in the drift as well. In a first step, a linear subspace is found that contains the solution space of the underlying rough differential equation (RDE). This subspace is associated to covariances of linear Ito-stochastic differential equations which is shown exploiting a Gronwall lemma for matrix differential equations. Orthogonal projections onto the identified subspace lead to a first exact reduced order system. Secondly, a linear map of the RDE solution (quantity of interest) is analyzed in terms of redundant information meaning that state variables are found that do not contribute to the quantity of interest. Once more, a link to Ito-stochastic differential equations is used. Removing such unnecessary information from the RDE provides a further dimension reduction without causing an error. The resulting reduced order rough equation can be solved numerically much faster than the original system. Therefore, our approach provides enormous savings in computing time and is hence beneficial from the practical point of view. Finally, we discretize a linear parabolic rough partial differential equation and a rough wave equation in space. The resulting large-order RDEs are subsequently tackled with the exact reduction techniques studied in this paper. We illustrate the enormous complexity reduction potential in the corresponding numerical experiments.
Jones, Dafydd Paul / Nimmo, Paul T. (Hrsg.), The Oxford Handbook of Karl Barth
Creators: name: Schroffner, Paul
Publisher: name: Theologie und Philosophie
Year: 1970

description: Theologie und Philosophie, Bd. 95 Nr. 4 (2020): Theologie und Philosophie, Band 95, Heft 4
Additional file 1 of Psychometric properties of the arabic translation of the Physical Appearance Comparison Scale-Revised (PACS-R) in adults
Creators: name: El Khoury, Marie Anne
name: Malaeb, Diana
name: Fawaz, Mirna
name: Chammas, Nancy
name: Soufia, Michel
name: Fekih-Romdhane, Feten
name: Obeid, Sahar
name: Hallit, Souheil
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Supplementary Material 1
sj-docx-1-sre-10.1177_23326492231162348 – Supplemental material for The Informal Safety Net: Social Network Activation among Hispanic Immigrants during COVID-19
Creators: name: Smith, Nicholas C.
name: Brooks, Caroline V.
name: Ekl, Emily A.
name: García, Melissa J.
name: Ambriz, Denise
name: Maupomé, Gerardo
name: Perry, Brea L.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 200299 Cultural Studies not elsewhere classified
subject: FOS: Other humanities
subject: Ethnic Studies
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-sre-10.1177_23326492231162348 for The Informal Safety Net: Social Network Activation among Hispanic Immigrants during COVID-19 by Nicholas C. Smith, Caroline V. Brooks, Emily A. Ekl, Melissa J. García, Denise Ambriz, Gerardo Maupomé and Brea L. Perry in Sociology of Race and Ethnicity
Harm reduction interventions for those residing in Housing First tenancies and other supported accommodation settings: A systematic scoping review protocol
Creators: name: Adams, Emily
name: Tweedlie, Leigh
name: Turner, Kieran
name: Malden, Stephen
name: Longmuir, Claire
name: Newman, Christian
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Public Health
subject: Medicine and Health Sciences

description: This project provides a protocol for a systematic scoping review investigating harm reduction practices taking place in Housing First and other supported accommodation settings.
Application of Machine Learning in Accelerating MPC for Chemical Processes
Creators: name: Klauco, Martin
name: Patrik, Valábek
Publisher: name: Zenodo
Year: 2024

description: The aim of this workshop is to provide hands-on experience for applications of machine learning tools in connection with control theory. Specifically, we introduce several possibilities as to how the MPC can be accelerated. We will provide a general overview and introduction to machine learning case studies suggesting suitable architectures and data preparation. Next, the workshop will introduce traditional MPC-mimicking procedures to generate approximate explicit control laws and procedures to general controllers posed as neural networks with stability guarantees. Case studies and examples will be tailored to chemical processes and problems arising in this domain. The workshop is primarily intended for graduate students and early-stage researchers and, as well as for all community members interested in hands-on applications of machine learning tools in process control. Furthermore, the workshop will be organized in interactive mode; hence, participants will gain experience in experiment preparation and coding examples.
Additional file 1 of Experimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype
Creators: name: Lorenzini, Luca
name: Zanella, Lorenzo
name: Sannia, Michele
name: Baldassarro, Vito Antonio
name: Moretti, Marzia
name: Cescatti, Maura
name: Quadalti, Corinne
name: Baldi, Simone
name: Bartolucci, Gianluca
name: Di Gloria, Leandro
name: Ramazzotti, Matteo
name: Clavenzani, Paolo
name: Costanzini, Anna
name: De Giorgio, Roberto
name: Amedei, Amedeo
name: Calzà, Laura
name: Giardino, Luciana
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Supplementary Material 1
STUDIO DEL RUOLO DELLA PROTEINA PRIONICA NELLA REGOLAZIONE DEL SONNO MEDIANTE L'UTILIZZO DI MODELLI MURINI TRANSGENICI
Creators: name: FERRARI, LORIS LUCIO
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: Introduction: an inherited form of Creutzfeldt-Jakob disease (CJD) is linked to the D178N/V129 mutation in the prion protein (PrP) gene. CJD is usually characterized by motor disorders, cognitive impairment and electroencephalographic alterations but recently sleep modification have been described.
Moreover a role for PrP in sleep has been proposed on the basis of data collected in Knock-out mice.
We generated a new mouse model of CJD (Tg(CJD)) that express the murine homologue of the D178N/V129 human mutation. We used as control mice Knock-out (KO) for the PrP, mice that over-express the normal form of the PrP Tg(WT) and Wt mice.
Goals: 1) the characterization of Tg(CJD) mice 2) the study of the evolution during aging of sleep and EEG patterns in our CJD model and in KO and Tg(WT) mice 3) the study of response to sleep deprivation in all our strains.
Materials: mice were anesthetized and instrumented for chronic EEG recordings, using standard techniques. Body movements were detected by means of an infrared sensor. Mice were individually housed in soundproof rooms, and maintained on a 12 hours light:dark cycle, at an ambient temperature between 23 and 24 �C. The study of the evolution of sleep patterns over time was conducted using animals of 3 different ages for each strain (6, 12 and 18 months).
Sleep deprivation was carried out by means of gentle handling and lasted 6 hours starting from the beginning of light phase.
Results: 18 months old Tg(CJD) mice showed a striking reduction in the amount of REM sleep compared to control strains. They also showed abundance of EEG alterations that remind those described in humans and motor alterations typical of CJD. The decrease in REM sleep is already present at 12 months of age in Tg(CJD) mice. Tg(CJD) and KO mice showed a flattening of the circadianity of sleep/wake cycle at 12 and 18 months of age. Sleep deprivation analysis showed a loss of rebound of REM sleep in mice with alterations of PrP.
Conclusions: We propose that Tg(CJD) mice establish the first transgenic animal model of a genetic prion disease recapitulating cognitive, motor and neurophysiological abnormalities of the human disorder. We also propose that REM sleep decrease in Tg(CJD) mice is an early sign of CJD and could be a new tool for rapid diagnosis of this disease.
QUASI-OPTIMALITY IN THE BACKWARD EULER-GALERKIN METHOD FOR LINEAR PARABOLIC PROBLEMS
Creators: name: TANTARDINI, FRANCESCA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: We analyse the backward Euler-Galerkin method for linear parabolic problems, looking for quasi-optimality results in the sense of C�a's Lemma. We cast the problem into the framework given by the inf-sup theory, and we analyse the spatial discretization, the discretization in time and the topic of varying the spatial discretization separately.
Concerning the spatial discretization, we prove the the H1-stability of the L2-projection is also a necessary condition for quasi-optimality, both in the H1(H-1)?L2(H1)-norm and in the L2(H1)-norm.
Concerning the discretization in time, we prove that the error in a norm that mimics the H1(H-1)?L2(H1)-norm is equivalent to the sum of the best errors with piecewise constants for the exact solution and its time derivative, if the partition is locally quasi-uniform.
Turning to the topic of varying the spatial dicretization, we provide a bound for the error that includes the best error and an additional term, which vanishes if there are not modifications of the spatial dicretization and which is consistent with the example of non convergence in Dupont '82. We combine these elements in an analysis of the backward Euler-Galerkin method and derive error estimates in case the spatial discretization is based on finite elements.
INTRAUTERINE FETAL DEATH: A FORENSIC-PATHOLOGY STUDY ABOUT THE ESTIMATION OF TIME OF DEATH
Creators: name: BATTISTINI, ALESSIO
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: In forensic pathology is of fundamental importance the diagnosis of time of death. If such an investigation is often complex with a well-preserved corpse, it is even more difficult in the case of a fetus dead in-utero affected by macerative post-mortal phenomena. The criteria currently available in pathological and obstetrical literature date back to the '60s and '70s and focus on macro- and microscopic characteristics of fetus and placenta almost never scientifically validated. They can turn to be inappropriate or useless in clinical practice, where the medical examiner often experience a complete mismatch between morphological and clinical data. The present study therefore arises from the necessity to update these thanatological criteria.
The actual validity of thanatological criteria proposed in literature has been assessed through a retrospective review of a selected population of 55 fetuses spontaneously dead in utero. The analysis was conducted for each case by applying the criteria previously analyzed in the literature (photographic documentation; histological evaluation of organs and placenta). It was then verified the actual correspondence between the morphological data, clinical data and estimated time of death based on known criteria, identifying the main problems and the possible influence of intrinsic or extrinsic factors.
Thereafter it has been developed an experimental prospective phase, focus the to the most critical phases of death-birth time (death within 12-24 hours). A TEM analysis was then conducted on skin and muscle samples from voluntary interruptions of pregnancy underwent an experimental macerative protocol, in order to identify possible stages of cell organelles degeneration positively correlated to the time of death. The main novelty emerged from the TEM study was a progressive vacuolization of cell structures.
Emotion-relevant Representations of Music Extracted by Convolutional Neural Networks Are Encoded in Medial Prefrontal Cortex
Creators: name: Kim, Seung-Goo
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 360301
subject: Music cognition
classificationCode: 520203
subject: Cognitive neuroscience

description: An oral presentation at the ICMPC17-APSCOM7 meeting (August 24-28, 2023, Tokyo, Japan)ICMPC.talk.2023-08-26_v2.pdf: Presented slidesKim.icmpc.2023.4min.mp4: A short (3 min) introductory videoKim+.2023.icmpc.pdf: The conference abstract published in the proceedings
IN SILICO STUDY OF PROTEIN PROTEIN INTERACTION STABILIZATION AND MECHANICAL FORCE APPLICATION ON BIOMOLECULES
Creators: name: CHAURASIA, SHILPI
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Targeting protein-protein interactions is a challenging task in drug discovery process. Despite the challenges, several studies have provided evidences for the development of small molecules modulating protein-protein interactions. In Part I, it is demonstrated that how a small molecule can induce the formation of an otherwise unstable protein-protein complex. A study of the stabilization of a FKBP12-FRB complex by a small molecule rapamycin is presented. The stability of the complex is analyzed and its interactions are characterized at the atomic level by performing free energy calculations and computational alanine scanning. It is shown that rapamycin stabilizes the complex by acting as a bridge between the two proteins; and the complex is stable only in the presence of rapamycin. The reported results and the good performance of standard molecular modeling techniques in describing the model system can be interesting not only in the design and development of improved molecules acting as FKBP12?FRB protein interaction stabilizers, but also in the somehow neglected study of protein-protein interactions stabilizers in general.
In Part II, studies regarding computational modeling of the application of mechanical force to biomolecules is presented. This part is further divided into two chapters since the investigations have been performed on two biological systems. In the first chapter of Part II (chapter 6), it is described that how the osmolyte molecules affect the mechanical unfolding of a peptide. The mechanical unfolding of peptide has been performed by using Steered Molecular Dynamics. In this study, the effect of four different osmolytes on the free energy difference between the folded and the denatured state have been calculated. The observed trend mirrors the expected behavior of the studied osmolytes and unfolding pathways analysis allows an insight into the mechanism of action of osmolytes.
After the successful application of Steered molecular dynamics technique on the ?-hairpin peptide, the same is applied on tubulin heterodimers for the in-depth study of the lateral and longitudinal interactions which are responsible for the stability and dynamics of the microtubules. In the other chapter of Part II (chapter 7), these interactions are studied with the help of mechanical dissociation of the tubulin heterodimers. These studies have allowed the identification of the critical interactions responsible for the binding of tubulin heterodimers laterally as well as longitudinally. The observations obtained could be important for the design of compounds that target these interactions and acts as microtubule inhibitors or stabilizers.
EVOLUZIONE DEL TROPISMO DI HIV-1 IN RELAZIONE ALLE MODIFICAZIONI DI LINFOCITI CD4 E VIREMIA E AL TRATTAMENTO: STUDIO PROSPETTIVO DI COORTE IN PAZIENTI CON INFEZIONE ACUTA/RECENTE E PAZIENTI AIDS PRESENTERS
Creators: name: TAU, PAMELA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: BACKGROUND: Acute infection and AIDS are more extreme phases of the natural history of HIV infection and the evolution of the virus. The acute infection represents a boost in plasma viremia, even before the immune system is able to prepare a neutralizing response to contain the infection. AIDS represents a decrease in immune competence after a stage of clinical latency.
The sequence analyses from amplification of the V3 region of gp120 within the env gene and the correlation with the development of immuno-virological profile of patients in our study allowed us to draw conclusions after comparing the two different phases of the disease.
METHODS: We enrolled 36 patients with acute/recent infection (n=20) or AIDS presenters (n=16). V3 sequences were obtained and co-receptor tropism was predicted using the Geno2pheno[coreceptor] algorithm. We analyzed various immuno-virological parameters in relation to the initial tropism of the virus: HIV-RNA, T CD4+ cells, (count and percentage) at baseline, at 6 and 12 months; T CD8+ cells (count) and CD4+/CD8+ ratio at baseline; HIV-RNA zenith and T CD4+ cells nadir. Phylogenetic analysis was performed using bioinformatic tools.
RESULTS: Our results demonstrated that a reconstitution of the immune system, evaluated as absolute recovery of CD4+ T cells from baseline to six months in both patient groups, showed a more favorable trend in patients with R5 compared to X4. This was most evident in acute/recent infection (R5: 256.5 cells / ?L; X4: 114 cells / ?L) compared to the advanced stage of AIDS (R5: 81 cells / ?L; X4: 71 cells / ?L). Multivariate analysis performed to assess the independent determinants of immune reconstitution showed a correlation with the two variables of considerable interest in the group of acute/recent infections: a positive correlation between the R5 tropism and the number of CD4 cells in both arms, at 6 and 12 months after therapy. Moreover, this analysis showed that, notwithstanding viral tropism, the gain in the number of CD4+ cells in the course of therapy at six months had an inverse correlation with the level of CD4+ cells at baseline. The risk associated with the advanced stage of the disease (i.e. CD4 counts ? 200 cells/?L in the arm of AIDS presenters) in accordance with the genotypic tropism confirmed the association between low values of FPR and more advanced stages of the disease.
CONCLUSIONS: Evolution of the V3 hypervariable region of gp120 located within the env gene, determining the tropism of the virus, influences the immuno-virological trend in the two cohorts of patients with an acute/recent infection and with an AIDS presentation.
CONTRADDICIBILIT� DI NORME E APPLICABILIT� DEL PRINCIPIO DI NON-CONTRADDIZIONE
Creators: name: MARTEWICZ, JAKUB
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: This Ph. D. thesis is dedicated to two great problems of the logic of norms. The first problem is: Can norms be terms of the relation of logical contradiction? The second problem is: Is it possible to formulate a deontic principle of non-contradiction (i.e. a principle of contradiction valid for norms)?
 In chapter 1, I examine various philosophical presuppositions of the two questions.
 In chapter 2, I examine four ways of interpreting the two questions.
 In chapter 3, I propose my own hypothesis of the possibile formulation of deontic principle of non-contradiction.
Additional file 3 of Which contributes more to the relict flora distribution pattern in East Asia, geographical processes or climate change? New evidence from the phylogeography of Rehderodendron kwangtungense
Creators: name: Jin, Jiehao
name: Zhao, Wanyi
name: Chen, Sufang
name: Gu, Chao
name: Chen, Zhihui
name: Liu, Zhongcheng
name: Liao, Wenbo
name: Fan, Qiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 3
sj-docx-1-jei-10.1177_10538151231191757 – Supplemental material for Patterns and Correlates of Developmental Profiles Using the Battelle Developmental Inventory Among Children in Early Intervention
Creators: name: Troxel, Mary
name: Sheldrick, R. Christopher
name: Eisenhower, Abbey
name: Carter, Alice S.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Education
Psychology not elsewhere classified
Special Education and Disability

description: Supplemental material, sj-docx-1-jei-10.1177_10538151231191757 for Patterns and Correlates of Developmental Profiles Using the Battelle Developmental Inventory Among Children in Early Intervention by Mary Troxel, R. Christopher Sheldrick, Abbey Eisenhower and Alice S. Carter in Journal of Early Intervention
Μηχανοχημική σύνθεση συγκρυστάλλου ασπιρίνης καρβαμαζεπίνης
Creators: name: Ραχμάνη, Κωνσταντίνα Ευάγγελου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Συγκρύσταλλος
Ασπιρίνη
Καρβαμαζεπίνη
Cocrystal
Aspirin
Carbamazepine

description: Οι συγκρύσταλλοι αποτελούν ένα νέο πεδίο έρευνας στην φαρμακευτική επιστήμη, καθώς συνδυάζουν τα πολλά πλεονεκτήματα που προσδίδουν στις φαρμακομορφές οι κρύσταλλοι, με την δυνατότητα της συγχορήγησης δύο δραστικών ουσιών ή και την πιο βελτιωμένη σταθεροποίηση τους. Στην παρούσα εργασία παρουσιάζεται η μηχανοχημική σύνθεση του συγκρυστάλλου του αντιεπιληπτικού φαρμάκου καρβαμαζεπίνη με το αναλγητικό ασπιρίνη, για την πιο στοχευμένη θεραπευτική αντιμετώπιση της επιληψίας. Ακόμα, παρουσιάζεται και μοριακή προσομοίωση της δομής και της μορφολογίας του κρυστάλλου, χρήση του προγράμματος του Cambridge Crystallographic Data Centre, Mercury. Υπολογίζονται οι κρυσταλλικές σταθερές του πλέγματος και προβλέπονται μηχανοχημικές συμπεριφορές βάση της επιφανειακής του χημείας. Οι εργαστηριακοί μέθοδοι που χρησιμοποιούνται είναι οι εξής: ο συγκρύσταλλος ταυτοποιείται με τεχνικές που επιβεβαιώνουν το σημείο τήξης του και διάθλαση ακτινών Χ για να επιβεβαιώσουν την κρυσταλλικότητά του. Τέλος, γίνεται άλεσή του με πολυμερή για στοχευμένη αποδέσμευση σε σημεία του γαστρεντερικού σωλήνα.
description: Co-crystals are a new field of research in pharmaceutical science, as they combine the many advantages that crystals give to pharmaceutical forms, with the possibility of co-administration of two active substances or their more improved stabilization. This paper presents the mechanochemical synthesis of the co-crystal of the antiepileptic drug carbamazepine with the analgesic aspirin, for the more targeted treatment of epilepsy. Also, a molecular simulation of the structure and morphology of the crystal is presented, using the Cambridge Crystallographic Data Centre's program, Mercury. Crystalline constants of the lattice are calculated and mechanochemical behaviors are predicted based on its surface chemistry. The laboratory methods used are: the co-crystal is identified by techniques that confirm its melting point and X-ray diffraction to confirm its crystallinity. Finally, it is milled with polymers for targeted release at points in the gastrointestinal tract
Noller, Jörg / Sans, Georg (Hrsg.), Luther und Erasmus über Freiheit
Creators: name: Batlogg, Andreas R.
Publisher: name: Theologie und Philosophie
Year: 1970

description: Theologie und Philosophie, Bd. 95 Nr. 4 (2020): Theologie und Philosophie, Band 95, Heft 4
CHEMICAL APPROACHES FOR IMPROVING DRUG DELIVERY OF KNOWN ANTICANCER COMPOUNDS
Creators: name: BORRELLI, STELLA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Different classes of squalene conjugates have been prepared: the first one containing a disulfide bond that, in the presence of glutathione, is able to trigger the release of a drug unit, the second one containing a tripepidyl sequence selectively cleaved by plasmin and also able to release a drug unit, the last one containinf a fluorescein 5(6)isothiocyanate unit. These compounds are able to self-assemble in water and can improve the delivery of active drugs to tumor tissues and can be helpful in the understanding of nanoparticle cellular uptake.
Additional file 2 of Improving selection decisions with mating information by accounting for Mendelian sampling variances looking two generations ahead
Creators: name: Niehoff, Tobias A. M.
name: ten Napel, Jan
name: Bijma, Piter
name: Pook, Torsten
name: Wientjes, Yvonne C. J.
name: Hegedűs, Bernadett
name: Calus, Mario P. L.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S1. Differences in the decisions made for selection based on the ProbSelOff and ExpBVSelOff criteria.
CYTOLOGIC EVALUATIONS OF CANINE INTESTINAL LYMPHOMA VIA ENDOSCOPIC BIOPSY
Creators: name: DIDIER, MARTINE
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Among the intestinal tumours of hematopoietic origin, lymphoma is the most common in the dog The multicentric lymphoma is more common than the intestinal form, while the .alimentary lymphoma usually accounts for 7% of all canine lymphomas and 5-7% of all gastrointestinal neoplasms. Recent studies have shown that canine intestinal lymphomas are to great extent of T-cell origin. Affected dogs most often present with a recent history of non-specific signs, like vomiting, diarrhea, anorexia and lethargy. The dogs involved are most commonly adult or old subjects, with an average age of 6,7 years. The most commonly involved breeds are Boxer, Shar-Pei and Golden Retriever. In light of the clinical and symptomatic overlap between IBD and enteropathy-type lym-phoma, patients are often submitted to endoscopic examination. The endoscopic examination of the small bowel in the lymphoma group showed an aspect referred by gastroenterologists as ?clobbedstone appearance? of the intestinal mucosa: the submucosal edema and the ulcerative disease with crisscrossing of the ulcers creates a pattern characterised by multiple, similarly-sized rounded densities that rise above a flattened plane, which has been likened to roads paved by multiple similarly-sized 'cobbled' stones. In dogs with this endoscopic aspect, the cytological examination alone has shown in our study a good diagnostic accuracy in the differential diagnosis between lymphoma and IBD. In fact, we argue that a cytological examination of squash-prep samples is a valuable method for the detection of a infiltrating enter-opahy. In our study, we evaluated the samples using an interpretative algorithm based on a reduced number of some selected cytomorphological clues. These criteria were: 1) presence of lymphoid blast cells, 2) fine structural change of the lymphoid blasts?s membrane, 3) presence of lympho-glandular bodies.
The most outstanding result, was the higher diagnostic accuracy of squash-prep cytology compared with endoscopic biopsy histology. Histopathology and immunohistochemistry are generally considered useful in the differential diagnosis between IBD and lymphoma. In our study however, although the evaluation of histopathologic results is not within the aims of the present work, the diagnostic performances of histopathology on endoscopic biopsies didn?t show a better accuracy better than those of cytology alone.
ROLE OF THE NOTCH LIGAND JAGGED1 IN ZEBRAFISH THYROID DEVELOPMENT
Creators: name: PORAZZI, PATRIZIA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: Notch signaling is the result of the complex interaction of various Delta and Jagged ligands and their Notch receptors. This signal is known to have a relevant and expanding role in cell fate determination, survival and proliferation during embryonic development. Though Notch pathway is known to have a fundamental role in different endocrine systems (i.e. anterior pituitary and pancreatic cell specification), its possible involvement in thyroid development has never been studied. Our previous gene expression analysis in a thyroid cell line revealed the presence of several transcripts belonging to the Jagged1-Notch pathway, thus suggesting its potential role in thyroid development. Then, we designed a series of experiments aimed at confirming these preliminary data in vitro and understand the role of Notch signaling in thyroid development. For this purpose, we took advantage of zebrafish, a versatile experimental model that has been shown to largely recapitulate the early events of mammalian thyroid gland organogenesis.
Gene expression analysis and experimental manipulations of zebrafish embryos were performed to identify the possible contribution of Jagged1 ligands to the thyroid development. Loss of Notch receptors activation in mind bomb (mib) mutants or DAPT-treated embryos led to an increased number of thyroid primordium cells. Conversely, Notch gain of function resulted in an impaired expression of the early thyroid marker genes (nkx2.1a; tg) in vivo.
Given that the entire pharyngeal architecture was seriously affected by these genetic conditions, the observed thyroid phenotypes could come from either cell-autonomous or non cell-autonomous activities of Notch signaling. In order to understand if Notch signaling plays a direct role in thyroid development, we then analyzed the co-expression pattern of the zebrafish jag1a and jag1b, orthologues of the mammalian Jagged1 ligand, and thyroid markers by double whole-mount in situ hybridization. These experiments show the co-expression of these ligands in the thyroid region, at different times. Next, to understand the biological role of these ligands, we took advantage of both morpholino knock-down strategy and specific zebrafish mutants. Thyroid development was impaired in several of these conditions, as shown by the altered expression of thyroid differentiation markers tg and slc5a5 and T4 production at different time points. As a consequence, a defective function of Jagged1 ligand might constitute a novel mechanism involved in the pathogenesis of congenital hypothyroidism.
APPROACHES TO THE TOTAL SYNTHESIS OF DICTYOSTATIN AND SYNTHESIS OF EPI-DICTYOSTATINS
Creators: name: ZANATO, CHIARA
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: The sponge-derived macrolide (-)-dictyostatin has been reported to exhibit paclitaxel-like effects on cellular microtubules and to inhibit human cancer cell proliferation at low nanomolar concentrations, with superior activity to that of the already very active discodermolide. Moreover, dictyostatin potently inhibits the binding of radiolabeled paclitaxel, discodermolide, and epothilone B to microtubules, and is also very active against paclitaxel-resistant cancer cell lines. Accordingly, (-)-dictyostatin is one of the most potent microtubule stabilizing agents discovered to date. In this PhD thesis, I report on a highly stereoselective total synthesis of (+)-9-epi-dictyostatin, whose key steps is the coupling reaction between two fragments, C1-C9 and C10-C26, followed by Yamaguchi macrolactonization and global deprotection. Eleven stereogenic centers and four stereogenic double bonds were obtained with a high level of stereocontrol. Surprisingly, the addition of vinylzincate C10-C26 to aldehyde C1-C9 led to a complete stereoselectivity in favor of the 9R-epimer, which is opposite to what reported by Ramachandran for a very similar coupling (P. V. Ramachandran, A. Srivastava, D. Hazra, Org. Lett. 2007, 9, 157-160). The synthesis of 12,13-bis-epi-dictyostatin, a non-natural analog of (-)-dictyostatin, has been also started and brought to its final steps. The development of dictyostatin analogs is an appealing goal from a pharmaceutical perspective, which provides interesting opportunities for structural simplification (whilst maintaining biological potency) and for better understanding the structure-activity relationships of this class of antitumor agents.
sj-docx-1-smo-10.1177_20503121231195416 – Supplemental material for Hygienic practice during complementary feeding and its associated factors among mothers/caregivers of children aged 6–24 months in Wolaita Sodo town, southern Ethiopia
Creators: name: Kassie, Gizachew Ambaw
name: Gebeyehu, Natnael Atnafu
name: Gesese, Molalegn Mesele
name: Chekol Abebe, Endeshaw
name: Mengstie, Misganaw Asmamaw
name: Seid, Mohammed Abdu
name: Alebachew Bayih, Wubet
name: Feleke, Sefineh Fenta
name: Amare Tesfa, Natnael
name: Dejenie, Tadesse Asmamaw
name: Bantie, Berihun
name: Solomon Kebede, Yenealem
name: Zemene, Melkamu Aderajew
name: Mengist Dessie, Anteneh
name: Anley, Denekew Tenaw
name: Asmare Adella, Getachew
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery
subject: Veterinary Medicine

description: Supplemental material, sj-docx-1-smo-10.1177_20503121231195416 for Hygienic practice during complementary feeding and its associated factors among mothers/caregivers of children aged 6–24 months in Wolaita Sodo town, southern Ethiopia by Gizachew Ambaw Kassie, Natnael Atnafu Gebeyehu, Molalegn Mesele Gesese, Endeshaw Chekol Abebe, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Wubet Alebachew Bayih, Sefineh Fenta Feleke, Natnael Amare Tesfa, Tadesse Asmamaw Dejenie, Berihun Bantie, Yenealem Solomon Kebede, Melkamu Aderajew Zemene, Anteneh Mengist Dessie, Denekew Tenaw Anley and Getachew Asmare Adella in SAGE Open Medicine
sj-docx-1-psx-10.1177_00323217231191399 – Supplemental material for The Paradox of Information Control Under Authoritarianism: Explaining Trust in Competing Messages in China
Creators: name: Wang, Chengli
name: Zhu, Jiangnan
name: Zhang, Dong
Publisher: name: SAGE Journals
Year: 2023
Subjects: International Relations

description: Supplemental material, sj-docx-1-psx-10.1177_00323217231191399 for The Paradox of Information Control Under Authoritarianism: Explaining Trust in Competing Messages in China by Chengli Wang, Jiangnan Zhu and Dong Zhang in Political Studies
Additional file 6 of Clinical epidemiology of Epstein-Barr virus-associated Lymphoproliferative Disorders (EBV-LPDs) in hospitalized children: A six-year multi-institutional study in China
Creators: name: Dilmurat, Dilara
name: Wang, Xinyu
name: Gao, Liwei
name: Tian, Jiao
name: Ai, Junhong
name: Zhang, Linlin
name: Liu, Mengjia
name: Feng, Guoshuang
name: Zeng, Yueping
name: Wang, Ran
name: Xie, Zhengde
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Marine Biology
Cancer
Hematology
Virology
Computational Biology

description: Supplementary Material 6.
Enders, Markus / Goebel, Bernd (Hrsg.), Die Philosophie der monotheistischen Weltreligionen im frühen und hohen Mittelalter
Creators: name: Fischer, N.
Publisher: name: Theologie und Philosophie
Year: 1970

description: Theologie und Philosophie, Bd. 95 Nr. 4 (2020): Theologie und Philosophie, Band 95, Heft 4
Infeção tardia por streptococcus agalactiae  – um caso de artrite séptica neonatal
Creators: name: Santos, Ângela
name: Sousa, Beatriz
name: Gama, Ana Paula
Publisher: name: NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL
Year: 2016
Subjects: Artrite séptica; gravidez; infeção tardia por Estreptococo grupo B; recém-nascido; rastreio pré-natal de Estreptococo grupo B

description: Introdução: A incidência da infeção neonatal precoce por Estreptococo do grupo B (EGB) tem diminuído substancialmente devido ao rastreio da colonização por EGB nas grávidas entre as 35 e as 37 semanas de gestação e à instituição da quimio-profilaxia intraparto. No entanto, a incidência da infeção tardia tem-se mantido constante na última década, não sendo afetada pela quimioprofilaxia materna intraparto. A infeção tardia afeta lactentes sem intercorrências obstétricas e com uma evolução neonatal precoce favorável. Outras vias de transmissão além da via vertical, tais como a via horizontal através dos contatos hospitalares ou familiares, poderão justificar a infeção tardia.
Caso clínico: Este caso clínico relata uma infeção tardia por EGB que se manifestou como um artrite séptica num lactente caucasiano de termo, com via de transmissão desconhecida. A morbilidade associada é descrita.
Discussão: Investigações adicionais sobre o mecanismo de transmissão da infeção tardia por EGB são imperativas para o desenvolvimento de medidas preventivas adequadas.
description: NASCER E CRESCER - BIRTH AND GROWTH MEDICAL JOURNAL, Vol 22, No 4 (2013)
Ανάπτυξη εφαρμογής επαυξημένης πραγματικότητας για την εξοικείωση με την Επιγραφική στην Τριτοβάθμια Εκπαίδευση
Creators: name: Ρωσίδου, Δήμητρα Φωτίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Επαυξημένη Πραγματικότητα
Αρχαία ελληνική επιγραφική
Τριτοβάθμια Εκπαίδευση
Augmented Reality (AR)
Ancient Greek epigraphy
Higher Education

description: Σκοπός της παρούσας εργασίας είναι η παρουσίαση μιας εφαρμογής επαυξημένης πραγματικότητας που αναπτύχθηκε για την εξοικείωση των προπτυχιακών φοιτητών του Τμήματος Φιλολογίας (Ειδίκευση Κλασικών Σπουδών) του Αριστοτελείου Πανεπιστημίου Θεσσαλονίκης με την Επιγραφική, η οποία, βέβαια, κατά έναν μεγάλο βαθμό μπορεί να χρησιμοποιηθεί και από οποιονδήποτε θέλει να αποκτήσει βασικές γνώσεις σχετικά με την αρχαία ελληνική επιγραφική. Στο θεωρητικό μέρος της εργασίας δίνονται βασικά στοιχεία τόσο για το αντικείμενο της Επιγραφικής όσο και για τις δυνατότητες που προσφέρει η τεχνολογία στην εκπαίδευση και ιδιαίτερα στον τομέα της Επιγραφικής, ενώ ταυτόχρονα όροι όπως Ψηφιακές Ανθρωπιστικές Επιστήμες, Επαυξημένη Πραγματικότητα, Ψηφιακά Εκπαιδευτικά Παιχνίδια και Φορητή Μάθηση παρουσιάζονται με συντομία. Στο πρακτικό μέρος της εργασίας περιγράφεται βήμα-βήμα ο τρόπος με τον οποίο σχεδιάστηκε η «εμπειρία» με επαυξημένη πραγματικότητα για τους φοιτητές και σχολιάζονται κριτικά οι απαντήσεις που έδωσαν στα ερωτηματολόγια που συλλέχθηκαν σχετικά με τις απόψεις τους έπειτα από τη χρήση της συγκεκριμένης εφαρμογής.
description: The purpose of this paper is the presentation of an augmented reality application- experience, which was developed for the familiarization of the undergraduate students of the Department of Philology (Classics) of the Aristotle University of Thessaloniki with Epigraphy. Of course, to a large extent it can be used by anyone who wants to acquire basic knowledge about ancient Greek epigraphy. In the theoretical part of the paper, basic elements are given both for the subject of Epigraphy and for the possibilities offered by technology in education and especially in the field of Epigraphy, while at the same time terms as Digital Humanities, Augmented Reality (AR), Digital Games and Mobile Learning are briefly presented. In the practical part of the paper, I explain step by step the way in which this "experience" with augmented reality was designed for the students and I critically comment on the answers, which the students gave in the questionnaires regarding the use of the proposed application.