cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Teasing Apart Overclaiming, Overconfidence, and Socially Desirable Responding
Creators: name: Bensch, Doreen
name: Paulhus, Delroy
name: Stankov, Lazar
name: Ziegler, Matthias
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: overclaiming
subject: socially desirable responding
subject: overconfidence
subject: nomological network
subject: positivity bias
subject: faking
subject: 150 Psychologie
subject: 610 Medizin und Gesundheit

description: Contamination with positivity bias is a potential problem in virtually all areas of psychological assessment. To determine the impact of positivity bias, one common approach is to embed special indicators within one’s assessment battery. Such tools range from social desirability scales to overconfidence measures to the so-called overclaiming technique. Despite the large literature on these different approaches and underlying theoretical notions, little is known about the overall nomological network—in particular, the degree to which these constructs overlap. To this end, a broad spectrum of positivity bias detection tools was administered in low-stakes settings (N = 798) along with measures of the Big Five, grandiose narcissism, and cognitive ability. Exploratory factor analyses revealed six first-order and two second-order factors. Overclaiming was not loaded by any of the six first-order factors and overconfidence was not explained by either of the two second-order factors. All other measures were confounded with personality and/or cognitive ability. Based on our findings, overclaiming is the most distinct potential indicator of positivity bias and independent of known personality measures.
title: Rethinking battlefield archaeology: campaign landscapes and liminal journeys in fourteenth century Northern England and Southern Scotland
Creators: name: Widell, Beatrice
Publisher: name: University of Reading
Year: 2022

description: This thesis investigates medieval campaign landscapes by reconstructing the routes that soldiers used before battle, and then exploring how the soldiers perceived their journey by analysing the route from a phenomenological perspective. The thesis is built on the premise that the journey to battle was important to medieval soldiers in their liminal state, given previous research on medieval journeying and liminality, such as pilgrimage, which has demonstrated that the journey was an important spiritual preparation for the pilgrims. This study is thus a response to previous research on medieval battlefields, in the subdisciplines of battlefield archaeology and conflict archaeology, which often has failed to consider broader landscape contexts. In order to answer the research enquiry, a two-step methodology is developed which; 1) reconstructs the most likely route to battle by addressing interdisciplinary evidence and identifying route corridors in the landscape; and 2) explores the route and its landscape context from a medieval phenomenological perspective. The method is tested on three fourteenth century battlefields in England and Scotland that were part of the AngloScottish wars (c.1296-c.1550), listed on Historic England and Historic Environment Scotland’s Register and Inventory of historic battlefields. The results showed that the soldiers used both Roman roads, smaller paths and crossed the terrain, and passed places of spiritual, symbolic and folkloric meaning in the medieval imagination. It is argued that the journey was perceived by the soldiers as an interior and mental preparation for battle, which included engaging somatically with sites of spiritual, liminal, martial and chivalric values. The results also propose that regional and national differences shaped the soldiers’ experience, for instance in saints’ cults, the motivation of and conduct for war, and the regional sense of the area.
The Zapotec or Ben 'Zaa (The Cloud People)
Creators: name: Stoll, Marijke
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The Zapotecs or Ben 'Zaa are an Indigenous peoples of Mexico that live primarily in the modern state of Oaxaca. They practice a syncretic Catholicism merged with traditional Prehispanic practices and beliefs.
Resilience in IIoT Applications. Dependable Cloud Services for Industrial Robots
Creators: name: Drabek, Christian
name: Wörter, Florian
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2021
Subjects: resilience
industrial internet of things
IIoT
cloud
robot operating system
ROS
service orchestration
safety

description: Resilientes Verhalten von IoT Anwendungen gewinnt immer mehr an Bedeutung je flexibler Softwarekomponenten z.B. als Services oder Container eingesetzt werden, sei es in Embedded Systems, in der Edge oder in der Cloud. Werden darüber hinaus auch steuernde Komponenten über Cloud-Technologien bereitgestellt und in die Cloud ausgelagert, müssen Mechanismen zum Einsatz kommen, die einen zuverlässigen und Safety konformen Einsatz garantieren. Dieser Vortrag beleuchtet die Herausforderungen flexibler, resilienter IoT Anwendungen und präsentiert Lösungsansätze aus aktuellen Forschungsvorhaben. Auf Basis von ROS wird eine prototypische Umsetzung vorgestellt.
Butonese Muslims also known as “Orang Butung or Orang Butuni”
Creators: name: Neelakantan, Vivek
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The Butonese, also known as Orang Butung or Orang Butuni is a collective term that embraces diverse ethnic groups (such as the Tukang Besi, Muna* and Wolio) from the island of Buton and neighboring islands that constitute the Indonesian province of Sulawesi Tenggara (Southeast Sulawesi). The Butonese population (estimated at ~ 236,000) mostly professes Islam. Historically seafarers, the Butonese migrated from Johor (today's Malaysia) to the island of Buton and have subsequently immigrated to the Moluccas, the center of Indonesia's spice production in search of better economic opportunities. The Butonese Sultanate (founded ~ 1540), with the conversion of the Sixth Raja of Buton to Islam, occupied a strategic position in the coastal trade between Java and Makassar, on one hand and the Moluccas, on the other. The sovereignty of the Butonese Sultanate was challenged around the seventeenth century due to the power struggle between Makassar and Ternate for the control of the spice trade. By 1613, Butonese Sultan La Elangi liaised with the Dutch East India Company (VOC) to free the Sultanate from the power struggle between Makassar and Ternate. But by 1669, the Sultanate was placed under the suzerainty of Pax Neerlandica by principle although in practice, the principality was independent until 1906. Subsequent to Indonesian independence (1945) and the transfer of power to the Indonesian Republic (1949), Buton continued to remain a Sultanate until 1960 when the principality was merged into the Indonesian republic. * Muna do not consider themselves Butonese although the Muna-Buton languages belong to the Celebic sub-group of Austronesian family to which Wolio belongs. So, it would be safe to generalize that Butonese refers to the inhabitants of the former Sultanate of Buton (prior to 1960).
Twenty years on – has patient-centered care been equally well integrated among medical specialties?
Creators: name: Lim, Sarah Ashley
name: Khorrami, Amir
name: Wassersug, Richard J
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The concept of ‘patient-centered care’ was touted as a pillar of good clinical practice and endorsed by the US Institute of Medicine in a seminal 2001 publication. We explore the extent to which differing medical specialties have engaged with the concept over the last 20 years and how and why this attention has varied among a sample of medical specialties since 2001. Reference to patient-centered care in the medical literature for selected specialties was used as a proxy for clinical application of patient-centered care in those disciplines. We undertook a statistical analysis and historical review of the medical literature that references the concept of patient-centered care in pediatrics, obstetrics and gynecology (OB-GYN), orthopedics, radiology, dermatology, and neurosurgery. We analyzed the extent to which the literature referencing patient-centered care has changed for the six disciplines since first mentioned in the Institute of Medicine 2001 publication. We measured changes over time in reference to patient-centered care in the medical literature for the six diverse medical specialties. The six disciplines differed significantly in reference to patient-centered care when comparing publications between the disciplines (p Uptake, attention, and applicability of the principles of patient-centered care have varied over the last 20 years. Differences among specialties appear to reflect true differences in patient centricities in the disciplines, with higher uptake in specialties that are person-oriented rather than technique-oriented. Greater engagement with patient-centered care correlates strongly with the number of female physicians in each field.
Research Report: Mapping Policy Responses to the Covid-19 Misinfodemic
Creators: name: Redeker, Dennis
name: Bernardes, Mariana
name: Davidian, Georgi
name: Hammond, Esther
name: Baller, Martin
name: Cazacu, Loredana
name: Cirolini, Silvia
name: Josephson, Alina-Anna
name: Recknagel, Florian
Publisher: name: Universität Bremen
Year: 2022
Subjects: subject: Covid-19
subject: information and communication technology
subject: Fake News
subject: Comparative analysis
subject: 320

description: This research report is the output from a seminar on Global Governance of Digital Technologies, which focused on the problem of misinformation related to Covid-19. Students of the seminar have contributed country and company case studies in which they illustrate these entities' policy responses.
Carfilzomib as a potential inhibitor of NADH-dependent enoyl-acyl carrier protein reductases of Klebsiella pneumoniae and Mycobacterium tuberculosis as a drug target enzyme: insights from molecular docking and molecular dynamics
Creators: name: Mahfuz, A. M. U. B.
name: Opazo, Felipe Stambuk
name: Aguilar, Luis F.
name: Iqbal, Muhammad Nasir
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Multiple antibiotic-resistant strains of Klebsiella pneumoniae can cause life-threatening infections. Bacterial enoyl-acyl carrier protein (ACP) reductases (ENRs) are considered critical targets for developing antibiotics. Our current study aims to identify inhibitors of K. pneumoniae ENRs (FabI and FabV). Due to the unavailability of experimental structures, protein models of FabI and FabV were predicted and validated in this study. Virtual screening of the 1930 FDA-approved drug database was conducted against the active site of the FabI protein with the help of the LEA3D server, and carfilzomib was chosen among the screened drugs for further docking studies. Carfilzomib, a proteasome inhibitor used in the treatment of multiple myeloma, was among the best-suited compounds obtained from the virtual screening and was found to be bactericidal in the in vitro experiment. Carfilzomib was docked against the active sites of the FabI and FabV proteins, and the ENR of Mycobacterium tuberculosis, InhA. Carfilzomib showed a high binding affinity with all three proteins. Molecular dynamics (MD) simulations were conducted following the docking studies. MD simulations revealed that carfilzomib binds strongly to the active sites of the above mentioned ENRs. Our study found that carfilzomib is a potential inhibitor of the ENRs of K. pneumoniae and M. tuberculosis. This is a possible mechanism of its bactericidal property against M. tuberculosis observed in vitro in addition to its predicted actions on zinc-dependent metalloprotease-1 and peptide deformylase, two other drug target enzymes of M. tuberculosis. Our study suggests that this drug could be used as a lead compound to develop antibiotics that can selectively act against ENRs of bacteria, without interfering with the activities of human proteasome. Communicated by Ramaswamy H. Sarma
A theoretical study on the role of stability of cytosine and its tautomers in DNA (deoxyribonucleic acid), and investigation of interactions of Na+, K+, Mg2+, Ca2+, Zn2+ metal ions and OH radical with cytosine tautomers
Creators: name: Sharafdini, Raziyeh
name: Ramazani, Shapour
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: 60506 Virology

description: In the present study, 21 cytosine tautomers were investigated so that some tautomers were reported for the first time in the gas phase and aqueous solution. C3 tautomer was the most stable tautomer in gas phase but C1 was the most stable structure in aqueous solution. The potential energy surface of all trajectories was determined for 21 tautomers and 22 transition states. Also, interactions of cytosine tautomers with Na+, K+, Mg2+, Ca2+ and Zn2+ metal ions were studied in gas phase and aqueous solution. Three types of interactions among metal ions and (N1 and O10), (N3 and O10) and (N3 and N9) of cytosine tautomers were investigated. The study of interaction energies of all complexes showed the stability of complexes in which interactions among Mg2+ and Zn2+ with tautomers were stronger than interactions among Ca2+, Na+ and K+ with tautomers, respectively. Some interactions of metal ions with cytosine tautomers made the most stable tautomers. So, the stability of rare tutomeric forms had a significant effect on stabilization of anomalous DNA (deoxyribonucleic acid) double helix and spontaneous mutations. Also, one of the most important causes of mutations in DNA (deoxyribonucleic acid) was the reaction of OH radical with nucleotide bases. So, interactions of OH radical with cytosine and its tautomers were investigated in gas phase and aqueous solution. Communicated by Ramaswamy H. Sarma
Statistical analysis/theoretical investigations of novel vascular endothelial growth factor of Davanoide from Scolymus grandifloras Desf as potent anti-angiogenic drug properties
Creators: name: Semaoui, Mohammed
name: Mesli, Fouzia
name: Dib, Mohammed El Amine
name: Tabti, Boufeldja
name: Achiri, Radja
name: Costa, Jean
name: Muselli, Alain
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Many pro-angiogenic factors acting directly or indirectly on the proliferation and differentiation of endothelial cells have been highlighted, in particular: VEGF (‘Vascular Endothelial Growth Factor’), FGF (‘Fibroblast Growth Factor’), PDGF (‘Platelet-Derived Growth Factor’), VEGF exerts its pro-angiogenic activity by binding to the surface of receptors with tyrosine kinase activity (VEGFR). The first objective of this study was to elucidate the composition of the essential oil of the roots of Scolymus grandifloras Desf. The second aim was to describe the intra-species variation in essential oil composition in natural populations of 21 oil samples from different Algerian locations using statistical analysis and bioinformatical study of VEGFR inhibition. The essential oil isolated from the root parts, was a really source of Davanoide compounds. The results of the docking simulation revealed that davanone (Ligand 13) has an affinity to interact with cDNA, VEGF and its receptors. The ADMET properties and BOILED-Egg plot validate the compound 13 pass the brain barrier and have high absorption in the intestines with good bioavailability. The findings of this study contribute to the pharmacological knowledge and the therapeutic efficacy of davanone and can initiate the development of new anti-angiogenic drugs. Results showed that essential oil of Scolymus grandiflorus presented a large level of percentage of davanone, davanol D1 and 2-hydroxy davanone. These components may be a new source of nontoxic anticancer agents. However, an additional in vitro and/or in vivo experimental study should make it possible to verify the theoretical results obtained in silico. Communicated by Ramaswamy H. Sarma
Tektonische Strukturen und tiefengeothermische Systeme des Münsterländer Kreidebeckens
Creators: name: Ackermann, Nicklas
name: Jüstel, Alexander
name: Kettermann, Michael
name: Ritzmann, Oliver
name: Lehrmann, Carsten
name: Bussmann, Gregor
name: Wellmann, Florian
name: :Unav
Publisher: name: Fraunhofer-Gesellschaft
Year: 2023

description: Das Münsterländer Kreidebecken im Norden Nordrhein-Westfalens (NRW) umfasst drei Karbonatgesteins-Formationen, welche potentielle, hydrothermale Systeme für die Entwicklung von Tiefengeothermie darstellen: der devonische Massenkalk als tiefstes Reservoir in ca. 5.000 m, der Kohlenkalk des Unterkarbons, sowie die karbonatischen Formationen des Cenomans und Turons der Kreide in bis zu 1.200 m Tiefe. Die vorliegende Studie fokussiert sich auf die Struktur und geothermischen Eigenschaften der Oberkreideschichten. Tiefreichende, tektonische Strukturelemente können zudem Fließwege für hydrothermale, korrosive Fluide darstellen und damit Verkarstung in den Karbonatreservoiren hervorrufen und sind im Gegensatz zu Randbereichen des Beckens und der Kohlenwasserstoffexploration im Zentrum des Beckens, relativ unbekannt. Für diese Studie wurden 2D-seismische Bestandsdaten, sowie Daten der Landesaufnahme des Geologischen Dienstes NRW mit Bohrungsdaten interpretiert. Das Kreide-Intervall zeigt mindestens zwei auffällige SW-NE streichende Zonen, in denen Transtensions/Transpressions-Strukturen (sog. Flower-Structures) identifiziert wurden. Diese können regional paläozoischen (d.h. variszischen) Antiklinalen zugeordnet, welche in ihren zentralen Bereichen Auf- bzw. Überschiebungen und extrem steiles Einfallen aufweisen. Es wird vermutet, dass diese Antiklinalen Schwächezonen darstellen, die während der Oberkreideinversion tektonisch reaktiviert wurden. Darüber hinaus geben erhöhte Impedanzkontraste im Bereich der Flower-Structures Hinweise auf erhöhte Porositäten und somit auch ggf. auf erhöhte Permeabilitäten, die notwendig für offene geothermische Systeme sind. Nachweise von Kohlenwasserstoffen (Gas) im Cenoman und Turon des Münsterländer Kreidebeckens durch Bohrungen unterstützen diese Beobachtung. Diese Strukturen stellen daher ein mögliches Ziel für mitteltiefe geothermische Projekte dar. Die prognostizierten höheren Permeabilitäten und Porositäten entlang dieser tektonischen Zonen in der Kreide begünstigt die Entwicklung von tiefengeothermischen Projekten im zentralen Bereich des Münsterländer Kreidebeckens.
Antimicrobial, cytotoxicity, molecular modeling and DNA cleavage/binding studies of zinc-naproxen complex: switching DNA binding mode of naproxen by coordination to zinc ion
Creators: name: Khandar, Ali Akbar
name: Mirzaei-Kalar, Zeinab
name: Shahabadi, Nahid
name: Hadidi, Saba
name: Abolhasani, Hoda
name: Hosseini-Yazdi, Seyed Abolfazl
name: Jouyban, Abolghasem
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: The intercalation DNA binding mode of the naproxen, a non-steroidal anti-inflammatory drug, has been reported previously. In this study, calf thymus deoxyribonucleic acid (CT-DNA) binding of zinc-naproxen complex, [Zn(naproxen)2(MeOH)2], at physiological pH has been investigated by multi-spectroscopic techniques and molecular docking. Zinc-naproxen complex displays significant binding property to the CT-DNA (Kb = 0.2 × 105 L.mol−1). All of the experimental results; relative increasing in viscosity of CT-DNA and fluorimetric studies using ethidium bromide (EB) and Hoechst 33258 probes, are indicative of groove binding mode of zinc-naproxen complex to CT-DNA. These results show that the coordination of naproxen to zinc metal switches the mode of binding from intercalation to groove. The molecular modeling also shows that the complex binds to the AT-rich region of minor groove of DNA. Structural and topography changes of DNA in interaction with the complex by atomic force microscopy (AFM) indicated that CT-DNA becomes swollen after interaction. The pUC18 plasmid DNA cleavage ability of zinc-naproxen complex by gel electrophoresis experiments revealed that zinc-naproxen complex cleaved supercoiled pUC18 plasmid DNA to nicked DNA. The cytotoxicity of the zinc complex performed by MTT method on HT29 and MCF7 cancer cell lines and on HEK 293 normal cell lines indicates that zinc complex has no cytotoxic effect on both HT29 and MCF7 cell lines but has better cytotoxicity effect on HEK 293 cell lines compared to cisplatin standard drug. The antimicrobial activity of the complex against Staphylococcus aureus and Escherichia coli bacteria revealed the high antimicrobial activity of the complex. Communicated by Ramaswamy H. Sarma
Multitarget in silico studies of Ocimum menthiifolium, family Lamiaceae against SARS-CoV-2 supported by molecular dynamics simulation
Creators: name: Albohy, Amgad
name: Zahran, Eman Maher
name: Abdelmohsen, Usama Ramadan
name: Salem, M. Alaraby
name: Al-Warhi, Tarfah
name: Al-Sanea, Mohammad M.
name: Abelyan, Narek
name: Khalil, Hany Ezzat
name: Desoukey, Samar Yehia
name: Fouad, Mostafa Ahmed
name: Kamel, Mohamed Salah
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The novel strain of human coronavirus, emerged in December 2019, which has been designated as SARS-CoV-2, causes a severe acute respiratory syndrome. Since then, it has arisen as a serious threat to the world public health. Since no approved vaccines or drugs has been found to efficiently stop the virulent spread of the virus, progressive inquiries targeting these viruses are urgently needed, especially those from plant sources. Metabolic profiling using LC-HR-ESI-MS of the butanol extract of Ocimum menthiifolium (Lamiaceae) aerial parts yielded 10 compounds including flavonoids, iridoids and phenolics. As it has been previously reported that some flavonoids can be used as anti-SARS drugs by targeting SARS-CoV-1 3CLpro, we chose to examine 14 flavonoids (detected by metabolomics and other compounds isolated via several chromatographic techniques). We investigated their potential binding interactions with the 4 main SARS-CoV-2 targets: Mpro, nsp16/nsp10 complex, ACE2-PD and RBD-S-protein via molecular docking. Docking results indicated that the nsp16/nsp10 complex has the best binding affinities where the strongest binding was detected with apigenin-7-O-rutinoside, prunin and acaciin with −9.4, −9.3 and −9.3 kcal/mol binding energy, respectively, compared to the control (SAM) with −8.2 kcal/mol. Furthermore, the stability of these complexes was studied using molecular dynamics of 150 ns, which were then compared to their complexes in the other three targets. MM-PBSA calculations suggested the high stability of acaciin-nsp16 complex with binding energy of −110 kJ/mol. This study sheds light on the structure-based design of natural flavonoids as anti-SARS-CoV-2 drugs targeting the nsp16/10 complex. Communicated by Ramaswamy H. Sarma
Donatism
Creators: name: Hoover, Jesse
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The Donatist controversy erupted in early fourth century Roman North Africa in the immediate aftermath of the Diocletianic persecution. The North African church was heir to the legacy of Cyprian of Carthage, whose belief that lapsed bishops were ineligible to administer the sacraments would prove crucial in the events that followed. During the Diocletianic persecution, a rift developed within the church over the status of bishops who had complied with the authorities and handed over their copies of the scriptures to be burned, an action referred to as traditio. In response to rumors that the newly-elected bishop of Carthage, a man named Caecilian, had been ordained by such a compromised bishop, a group of seventy bishops from Numidia denounced his ordination as illegitimate and elevated an alternate candidate to the Carthaginian bishopric. After their candidate was rejected at the councils of Rome in 313 and Arles in 314, the dissidents, called “Donatists” by their opponents after their charismatic second leader, Donatus of Carthage, were considered schismatic by the wider Christian church. Within Roman North Africa proper (modern Tunisia, Algeria, and parts of Morocco), congregations that viewed Donatus and his successors as the legitimate bishops of Carthage seem to have been in the majority throughout the fourth century. Failed repressions by the emperors Constantine in the 320s and Constans in the late 340s created a strong self-narrative among the dissidents that theirs was the church that “suffers persecution but does not cause it” (Gesta Carth. 3.258), though violent reprisals by Donatist partisans known as Circumcellions against their Caecilianist opponents tarnished this claim. Despite their “schismatic” status, Donatist writers were influential among Latin Christian communities outside of North Africa, especially the maverick theologian Tyconius, whose Book of Rules and Commentary on the Apocalypse dominated Western Christian approaches to exegesis and eschatology well into the Carolingian era. The Cyprianic position that schismatic bishops could not legitimately perform the sacraments led many Donatist communities to require converts from the rival church to be baptized upon entry, a practice their opponents decried as “rebaptism.” The decline of the dissident communion can be attributed in large part to the efforts of Caecilianist opponents like Augustine of Hippo and Aurelius of Carthage in the 390s, which culminated in an imperial edict in 405 imposing heavy fines and confiscation of property on adherents. This edict was reified in 411 at an imperially-sanctioned debate between the two sides at Carthage. Donatism survived as a coherent movement long after the Vandal invasion of the 430s, and was last referenced as a contemporary phenomenon in the letters of Pope Gregory I late in the sixth century.
กลยุทธ์ในการสรรหาและคัดเลือกทรัพยากรมนุษย์เมื่อองค์การก้าวสู่ความเป็นนานาชาติ ด้วยการควบรวมกิจการระหว่างประเทศ : กรณีศึกษาของทีซีซีกรุ๊ป
Creators: name: จตุรงค์ นภาธร
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016
Subjects: การบริหารทรัพยากรมนุษย์, บรรษัทข้ามชาติ, บรรษัทข้ามชาติจากประเทศกำลังพัฒนาหรือประเทศที่เป็นตลาดเกิดใหม่, การควบรวมกิจการระหว่างประเทศ, ตลาดแรงงานภายนอกองค์การ

description: 150 (เม.ย.-มิ.ย. 59), 39, วารสารบริหารธุรกิจ JBA
ประเด็นร่วมสมัยของการจัดการธุรกิจระหว่างประเทศ
Creators: name: ชัยวัฒน์ ใบไม้
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016
Subjects: การจัดการธุรกิจระหว่างประเทศ, การวิเคราะห์เนื้อหา

description: 150 (เม.ย.-มิ.ย. 59), 39, วารสารบริหารธุรกิจ JBA
Identification of naphthyridine and quinoline derivatives as potential Nsp16-Nsp10 inhibitors: a pharmacoinformatics study
Creators: name: Aldahham, Bilal J. M.
name: Al-Khafaji, Khattab
name: Saleh, Mohanad Yakdhan
name: Abdelhakem, Adel Mohamed
name: Alanazi, Amer M.
name: Islam, Md Ataul
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: This research is a recent effort to explore some new heterocyclic compounds as novel and potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibition. The SARS-CoV-2 is causative agent of coronavirus disease 2019 (COVID-19) pandemic. A set of 58 molecules belongs to the naphthyridine and quinoline derivatives have been recently synthesized and considered for structure-based virtual screening against Nsp16-Nsp10. Molecular docking was virtually performed to screen for anti-SARS-CoV-2 activity against Nsp16-Nsp10. Fourteen out of fifty-eight compounds were exhibited binding affinity higher than co-crystal bound ligand s-adenosylmethionine (SAM) toward Nsp16-Nsp10. Further, the in silico pharmacokinetics assessment was carried out and it was found that two molecules possess the acceptable pharmacokinetic profile, hence considered promising Nsp16-Nsp10 inhibitors. The binding interaction analysis was revealed some crucial binding interactions between the final selected two molecules and ligand-binding amino acid residues of Nsp16-Nsp10 protein. In order to explore the characteristics of the protein–ligand complex and how selected small molecules retained inside the receptor cavity in dynamic states, all-atoms conventional molecular dynamics (MD) simulation was performed. Several factors were obtained from the MD simulation trajectory evidently suggested the potentiality of the molecules and stability of the protein–ligand complex. Finally, the binding affinity of both molecules and SAM was explored through the MM-GBSA approach which explained that both molecules possess strong affection towards the Nsp16-Nsp10. Hence, from the pharmacoinformatics assessment, it can be concluded that both heterocyclic compounds might be crucial for SARS-CoV-2 inhibition, subjected to experimental validation. Communicated by Ramaswamy H. Sarma
STRESSNING TALABALAR HAYOTIDAGI O'RNI VA ROLI
Creators: name: Imonova, Maftuna
name: O'ralova, Dinora
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada stress va stresni keltirib chiqarivchi omillar,hamda uni talabalar hayotidagi o'ri va roli haqida sõz boradi.
Heme-iron ligand (M80-Fe) in cytochrome c is destabilizing: combined in vitro and in silico approaches to monitor changes in structure, stability and dynamics of the protein on mutation
Creators: name: Naiyer, Abdullah
name: Khan, Bushra
name: Islam, Asimul
name: Hassan, Md. Imtaiyaz
name: Sundd, Monica
name: Ahmad, Faizan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Structure, stability and dynamics properties of horse cytochrome c (cyt c) and its genetically engineered M80G mutant have been investigated. The nature of the Met80 axial ligation to heme iron is believed to be the major determinant of the oxidation-reduction reactions inside and outside the cell of a particular cytochrome. This ligation has played an important role in the studies of protein structure, stability and protein folding/unfolding. To understand this ligation better, Met80 of horse cyt c has been mutated to Gly that is unable to bind to the heme iron. We have examined the effect of the M80G mutation on the structure and stability of the WT (wild type) protein by using absorbance spectroscopy, far-UV, near-UV and Soret circular dichroism, fluorescence spectroscopy and differential scanning calorimetry. We have observed that mutation caused a partial loss of secondary and tertiary structure with slightly increased overall stability of the protein. We have also measured the dynamic behavior of WT cyt c and its M80G mutant in the oxidized form (Fe3+) using the essential dynamics (ED) method. A 400 ns MD simulations were run for WT cyt c and its mutant M80G in water using GROMOS96 force field. MD results revealed that the stability and flexibility increased in mutant M80G (Fe…S (Met80) bond removed). Essential dynamics analysis revealed that the first five eigenvectors were mainly involved in overall motions of WT cyt c and its M80G mutant but the amplitude of concerted motions decreased in M80G mutant relative to WT cyt c. Communicated by Ramaswamy H. Sarma
Lean Analytics: Use Data to Build a Better Startup Faster
Creators: name: นภดล ร่มโพธิ์
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016

description: 150 (เม.ย.-มิ.ย. 59), 39, วารสารบริหารธุรกิจ JBA
รัฐบาลควรจัดเก็บภาษีสรรพสามิตจากโทรศัพท์เคลื่อนที่อีกครั้ง?
Creators: name: ธำรงศักดิ์ เศวตเลข
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016
Subjects: ภาษีจากโทรศัพท์เคลื่อนที่, ภาษีจากกิจการโทรคมนาคม, ภาษีสรรพสามิต

description: 150 (เม.ย.-มิ.ย. 59), 39, วารสารบริหารธุรกิจ JBA
The Association Between Firm Characteristics and Growth Opportunities: Empirical Evidence from the Emerging Market of Thailand
Creators: name: Sirada Nuanpradit
Publisher: name: คณะพาณิชยศาสตร์และการบัญชี มหาวิทยาลัยธรรมศาสตร์
Year: 2016
Subjects: Growth Opportunities, Emerging Market

description: 150 (เม.ย.-มิ.ย. 59), 39, วารสารบริหารธุรกิจ JBA
Examining interlanguage pragmatics from a relevance-theoretic perspective: Challenges in L2 production
Creators: name: Marcet, Erika
name: Sawamoto, Ryoko
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 47
subject: Language, communication and culture

description: This paper explores three pragmatic challenges that learners of Japanese as L2 encountered during their study abroad programs and work placements in Japan. These challenges are examined within the framework of Relevance Theory. Research on interlanguage pragmatics of L2 Japanese is limited in scope, as studies mostly focus on speech acts and other sociolinguistic and interactional strategies. As a result, researchers have yet to formally establish how learners of Japanese have difficulties in regard to their production of meaning. This study draws on open-ended questionnaires, semi-structured interviews and focus group discussions to determine the pragmatic competence of L2 students across two Irish universities. The study demonstrates that learners have difficulties with processing both linguistic encoding and phenomena that involve inference. That is, learners’ inability to activate their pragmatic competence hinders their ability to produce communicative acts. Findings lend support to the need to enhance pragmatic competence among L2 learners through specific cognitive processes. This paper also contributes to the need for interlanguage pragmatics to be pursued in conjunction with current developments in Relevance Theory. It is argued that ideas developed within Relevance Theory can be particularly beneficial to the teaching and learning of pragmatic competence in the L2 classroom.
High-throughput virtual screening of novel potent inhibitor(s) for Human Vanin-1 enzyme
Creators: name: Gurung, Arun Bahadur
name: Bhutia, Jigmi Tshering
name: Bhattacharjee, Atanu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Vanin-1 (VNN1) is a glycosylphosphatidylinositol (GPI)-anchored ectoenzyme which hydrolyzes pantetheine to pantothenic acid and cysteamine. It has emerged as a promising drug target for many human diseases associated with oxidative stress and inflammatory pathways. In the present study we used structure-based virtual screening approach for the identification of small molecule inhibitors of vanin-1. A chemical library consisting of natural compounds, synthetic compounds and RRV analogs were screened for drug-like molecules. The filtered molecules were subjected to molecular docking studies. Three potential hits—ZINC04073864 (Natural compound), CID227017 (synthetic compound) and CID129558381 (RRV analog)—were identified for the target enzyme. The molecules form good number of hydrogen bonds with the catalytic residues such as Glu79, Lys178 and Cys211. The apo-VNN1 and VNN1-ligand complexes were subjected to molecular dynamics (MD) simulation for 30 ns. The geometric properties such as root mean square deviation, radius of gyration, solvent accessible surface area, number of hydrogen bonds and the distance between the catalytic triad residues-Glu79, Lys178 and Cys211 were altered upon binding of the compounds. Essential dynamics and entropic studies further confirmed that the fluctuations in VNN1 decrease upon binding of the compounds. The lead molecules were stable throughout the simulation time period. Molecular Mechanics Poisson–Boltzmann Surface Area (MM/PBSA) studies showed that Van der Waals interaction energy contributes significantly to the total binding free energy. Thus, our study reveals three lead molecules—ZINC04073864, CID227017 and CID129558381 as potential inhibitors of Vanin-1 which can be validated through further studies. Communicated by Ramaswamy H. Sarma
Interaction of indole-3-acetic acid with horseradish peroxidase as a potential anticancer agent: from docking to molecular dynamics simulation
Creators: name: Zarei, Mahboubeh
name: Rahbar, Mohammad Reza
name: Negahdaripour, Manica
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: The oxidation process, catalyzed by the peroxidase enzymes, occurs in all domains of life to detoxify the hydrogen peroxide toxicity. The most well-known, applicable and vastly studied member of the peroxidases family is horseradish peroxidase (HRP), especially the isoenzyme C (HRP C). HRP (primarily HRP C) is commercially available and applicable in biotechnology and diagnosis. Recently, a novel application of HRP has been introduced in cancer therapy as the combination of HRP with indole-3-acetic acid (IAA). The anticancer activity of HRP/IAA complex is through oxidation of IAA by HRP in hypoxic tumor condition, which leads to apoptosis and cancerous cell death. However, the molecular interaction of HRP/IAA has not been elucidated. Identifying the interaction of IAA with HRP would provide a better insight into its function and applications. In this study, molecular docking and molecular dynamics (MD) simulation were applied to determine the molecular interaction of the IAA/HRP complex. The docking study represented that IAA bound at the ‘exposed’ heme edge of the HRP enzyme, and the IAA entrance to the enzyme was situated at the carboxymethyl side-chain of the selected structure. Our computational results showed the HRP/IAA complex structure stability. While hydrogen bond formation with ARG38 and HIS42 stabilized the substrate, hydrophobic interactions with Phe68, Gly69, Leu138, Pro139, Pro141 and Phe179 contributed to IAA/HRP complex stability. The results can help to better understand peroxidase enzyme activity and would pave the way for future development of new therapeutics with improved anticancer efficacy. Communicated by Ramaswamy H. Sarma
Qasr al-Bint
Creators: name: Plekhov, Daniel
Publisher: name: Database of Religious History (DRH)
Year: 2022

description: The Qasr al-Bint is a free-standing temple structure built at Petra by the Nabataeans, likely sometime around the first century BCE. The structure is one of the most prominent and centrally located at Petra, standing at the western end of the main colonnaded street and nearby to other notable buildings, such as the Great Temple. Even so, the Qasr al-Bint is structurally set apart from these other buildings, both in terms of its unique alignment as well as by a temenos enclosure and gate structure that separates it from the rest of Petra's city center. Within this sanctuary enclosure are other associated structures, most notably an altar directly across from the entrance to the Qasr al-Bint. This altar was dedicated to the principal Nabataean deity Dushara, and it has been proposed that the Qasr al-Bint itself was also dedicated to this deity (alternatives include Al-Uzza/Aphrodite). With the Roman annexation of the Nabataean kingdom in 106 CE, remodeling took place of much of Petra's principal monuments, including the Qasr al-Bint, and it is possible that the temple was rededicated to other deities at this time. Little else is known about the use or functions of the Qasr al-Bint during the Nabataean and Roman periods. Given its prominent location and size, it likely functioned as one of the principal religious structures of Petra and the Nabataeans, but little else can be said about what kinds of rituals or activities took place at the temple, who participated in them, or how frequently they occurred. We do not even know what name the temple originally had. The modern Arabic name today is translated as "the palace of (Pharaoh’s) daughter," in reference to local folklore. By the third century CE, the structure seems to have been largely abandoned and in disrepair, perhaps as a result of earthquakes, the Palmyrene revolt, or general lack of maintenance.
Finding ∀∃ Hyperbugs using Symbolic Execution
Creators: name: Correnson, Arthur
name: Nießen, Tobias
name: Finkbeiner, Bernd
name: Weissenbacher, Georg
Publisher: name: CISPA
Year: 2024

description: Many important hyperproperties, such as refinement and generalized non-interference, fall into the class of ∀∃ hyperproperties and require, for each execution trace of a system, the existence of another trace relating to the first one in a certain way. The alternation of quantifiers renders ∀∃ hyperproperties extremely difficult to verify, or even just to test. Indeed, contrary to trace properties, where it suffices to find a single counterexample trace, refuting a ∀∃ hyperproperty requires not only to find a trace, but also a proof that no second trace satisfies the specified relation with the first trace. As a consequence, automated testing of ∀∃ hyperproperties falls out of the scope of existing automated testing tools. In this paper, we present a fully automated approach to detect violations of ∀∃ hyperproperties in software systems. Our approach extends bug-finding techniques based on symbolic execution with support for trace quantification. We provide a prototype implementation of our approach, and demonstrate its effectiveness on a set of challenging examples.
Synthesis, characterization, antiproliferative of pyrimidine based ligand and its Ni(II) and Pd(II) complexes and effectiveness of electroporation
Creators: name: Alkış, Mehmet Eşref
name: Buldurun, Kenan
name: Turan, Nevin
name: Alan, Yusuf
name: Yılmaz, Ünzile Keleştemur
name: Mantarcı, Asim
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: In the study, a new Schiff base (ligand) was obtained using 4-aminopyrimidine-2(1H)-one, the starting material, and 2,3,4-trimethoxy benzaldehyde. Ni(II) and Pd(II) complexes were obtained from the reaction of the ligand and NiCl2·6H2O, PdCl2(CH3CN)2 (1:1 ratio). These compounds were characterized using the elemental and mass analysis, 1H, 13C-NMR, FT-IR, UV-Vis, magnetic susceptibility, thermal analysis, and the X-ray diffraction analyses. The antiproliferative activities of the synthesized ligand, Ni(II) and Pd(II) complexes were identified on the HepG2 (human liver cancer cells) cell line and their biocompatibility was tested on the L-929 (fibroblast cells) cell line by the MTT analysis method. Furthermore, the effects of electroporation (EP) on the cytotoxic activities of synthesized compounds were investigated in HepG2 cancer cells. According to the MTT findings of the study, the ligand did not exhibit an antiproliferative activity while its Ni(II) and Pd(II) complexes exhibited an antiproliferative activity. Moreover, it was observed that the antiproliferative activity of the Pd(II) complex was stronger than that of the Ni(II) complex. The combined application of EP + compounds is much more effective than the usage of the compounds alone in the treatment of HepG2 cancer cells. The EP increased the cytotoxicity of the Ni(II) and Pd(II) complexes by 1.66, and 2.54 times, respectively. It was concluded that Ni(II) and Pd(II) complexes may contribute as potential anti-cancer agents for the treatment of hepatocellular carcinoma and yield promising results in the case of being used in ECT. Communicated by Ramaswamy H. Sarma
Secondary structural analysis of non-mulberry silk fibroin nanoparticles synthesized by using microwave and acetone method
Creators: name: Asapur, Prithvi
name: Mahapatra, Santosh Kumar
name: Banerjee, Indrani
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: The 3D structure analysis for Muga silk protein was predicted through homology modeling and Ramachandran plot with the determination of quality index for Stereo/packing and 3D quality index. Silk Nanoparticles were synthesized using conventional desolvation and microwave-assisted radiolysis method from Muga silk fibroin. The secondary structure evolution due to two different synthesis methods was investigated using FTIR and Circular Dichroism (CD) spectroscopy. The microwave synthesized nanoparticles showed enhanced β-sheet content than desolvation synthesized nanoparticles. The conformational changes of Muga silk fibroin protein to nanoparticle followed an ordered transition from random coil to α-helix then from α-helix to β-turn and from β-turn to β-sheets where α-helix and β-turn are the intermediate forms before getting stabilized to the metastable β-sheets structure. The thermodynamics involved in secondary structure evolution was studied from CD analysis and activation energy involved in the formation of the secondary structure was determined. Communicated by Ramaswamy H. Sarma