cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Process of diffusing cancer survivorship care into oncology practice
Creators: name: McCabe, Mary
name: Golden, Shannon
name: Ganz, Patricia A
name: Baker, Scott
name: Campbell, Marci K
name: Tessaro, Irene
name: Jacobs, Linda
name: Rosenstein, Donald L
name: Miller, Kenneth D
name: Syrjala, Karen
name: Gellin, Mindy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The LIVESTRONG Centers of Excellence were funded to increase the effectiveness of survivorship care in oncology practice. This study describes the ongoing process of adopting and implementing survivorship care using the framework of the diffusion of innovation theory of change. Primary data collection included telephone interviews with 39 members from the eight centers and site visits. Organizational characteristics, overall progress, and challenges for implementation were collected from proposals and annual reports. Creating an awareness of cancer survivorship care was a major accomplishment (relative advantage). Adoption depended on the fit within the cancer center (compatibility), and changed over time based on trial and error (trialability). Implementing survivorship care within the existing culture of oncology and breaking down resistance to change was a lengthy process (complexity). Survivorship care became sustainable as it became reimbursed, and more new patients were seen (observability). Innovators and early adopters were crucial to success. Diffusion of innovation theory can provide a strategy to evaluate adoption and implementation of cancer survivorship programs into clinical practice.
Additional file 4 of HIV awareness, pre-exposure prophylaxis perceptions and experiences among people who exchange sex: qualitative and community based participatory study
Creators: name: Kislovskiy, Yasaswi
name: Erpenbeck, Sarah
name: Martina, Jamie
name: Judkins, Courtney
name: Miller, Elizabeth
name: Chang, Judy C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 4.
A new approach on the stability analysis in ELKO cosmology
Creators: name: S., A. Pinho S.
name: Pereira, S. H.
name: Jesus, J. F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work it has been developed a new approach to study the stability of a system composed by an ELKO field interacting with dark matter, which could give some contribution in order to alleviate the cosmic coincidence problem. It is assumed that the potential which characterizes the ELKO field is not specified, but it is related to a constant parameter $δ$. The strength of the interaction between matter and ELKO field is characterized by a constant parameter $β$ and it is also assumed that both ELKO field as matter energy density are related to their pressures by equations of state parameters $ω_ϕ$ and $ω_m$, respectively. The system of equations is analysed by a dynamical system approach. It has been found the conditions of stability between the parameters $δ$ and $β$ in order to have stable fixed points for the system for different values of the equation of state parameters $ω_ϕ$ and $ω_m$, and the results are presented in form of tables. The possibility of decay of ELKO field into dark matter or vice versa can be read directly from the tables, since the parameters $δ$ and $β$ satisfy some inequalities. It allows us to constrain the potential assuming that we have a stable system for different interactions terms between the ELKO field and dark matter. The cosmic coincidence problem can be alleviated for some specific relations between the parameters of the model.
description: 16 pages, some new comments in the Introduction and at the begining of Section II
Magnetic anisotropy of FePt nanoparticles
Creators: name: Kabir, Alamgir
name: Hu, Jun
name: Turkowski, Volodymyr
name: Wu, Ruqian
name: Rahman, Talat S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We carry out a systematic theoretical investigation of Magneto Crystalline Anisotropy (MCA) of L10 FePt clusters with alternating Fe and Pt planes along the (001) direction. We calculate the structural relaxation and magnetic moment of each cluster by using ab initio spin-polarized density functional theory (DFT), and the MCA with both spin-polarized DFT (including spin-orbit coupling self-consistently) and the torque method. We find that the MCA of any composite structure of a given size is enhanced with respect to that of the same-sized pure Pt or pure Fe cluster as well as to that of any pair of Fe and Pt atoms in bulk L10 FePt. This enhancement results from the hybridization we observe between the 3d orbital of the Fe atoms and the 5d orbital of their Pt neighbors. This hybridization, however, affects the electronic properties of the component atoms in significantly different ways. While it somewhat increases the spin moment of the Fe atoms, it has little effect on their orbital moment; at the same time, it greatly increases both the spin and orbital moment of the Pt atoms. Given the fact that the spin-orbit coupling (SOC) constant of Pt is about 7 times greater than that of Fe, this Fe-induced jump in the orbital moment of the Pt atoms produces the increase in MCA of the composite structures over that of their pure counterparts. That any composite structure exhibits higher MCA than bulk L10 FePt results from the lower coordination of Pt atoms in the cluster, whether Fe or Pt predominates within it. We also find that bipyramidal clusters whose central layer is Pt have higher MCA than their same-sized counterparts whose central layer is Fe. This results from the fact that Pt atoms in such configurations are coordinated with more Fe atoms than in the latter. By thus participating in more instances of hybridization, they contribute higher orbital moments to the overall MCA of the unit.
Additional file 5 of HIV awareness, pre-exposure prophylaxis perceptions and experiences among people who exchange sex: qualitative and community based participatory study
Creators: name: Kislovskiy, Yasaswi
name: Erpenbeck, Sarah
name: Martina, Jamie
name: Judkins, Courtney
name: Miller, Elizabeth
name: Chang, Judy C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 5.
Weight loss social support in 140 characters or less: use of an online social network in a remotely delivered weight loss intervention
Creators: name: Turner-McGrievy, Gabrielle M
name: Tate, Deborah F
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Little is known about how online social networking can help enhance weight loss. To examine the types of online social support utilized in a behavioral weight loss intervention and relationship of posting and weight loss. A sub-analysis of the content and number of posts to Twitter among participants (n = 47) randomized to a mobile, social network arm as part of a 6-month trial among overweight adults, examining weight loss, use of Twitter, and type of social support (informational, tangible assistance, esteem, network, and emotional support). A number of Twitter posts were related to % weight loss at 6 months (p < 0.001). Initial reported weight loss predicted engagement with Twitter (p < 0.01) but prior Twitter use or initial Twitter engagement did not. Most Twitter posts (total posts n = 2,630) were Informational support (n = 1,981; 75 %), with the predominant subtype of Teaching (n = 1,632; 62 %), mainly in the form of a status update (n = 1,319). Engagement with Twitter was related to weight loss and participants mainly used Twitter to provide Information support to one another through status updates.
Additional file 6 of HIV awareness, pre-exposure prophylaxis perceptions and experiences among people who exchange sex: qualitative and community based participatory study
Creators: name: Kislovskiy, Yasaswi
name: Erpenbeck, Sarah
name: Martina, Jamie
name: Judkins, Courtney
name: Miller, Elizabeth
name: Chang, Judy C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6.
Two-mode squeezed states as Schrodinger-cat-like states
Creators: name: Oudot, E.
name: Sekatski, P.
name: Fröwis, F.
name: Gisin, N.
name: Sangouard, N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In recent years, there has been an increased interest in the generation of superposition of coherent states with opposite phases, the so-called photonic Schrodinger-cat states. These experiments are very challenging and so far, cats involving small photon numbers only have been implemented. Here, we propose to consider two-mode squeezed states as examples of a Schrodinger-cat-like state. In particular, we are interested in several criteria aiming to identify quantum states that are macroscopic superpositions in a more general sense. We show how these criteria can be extended to continuous variable entangled states. We apply them to various squeezed states, argue that two-mode squeezed vacuum states belong to a class of general Schrodinger-cat states and compare the size of states obtained in several experiments. Our results not only promote two-mode squeezed states for exploring quantum effects at the macroscopic level but also provide direct measures to evaluate their usefulness for quantum metrology.
description: 5 pages + appendix, one figure
School factors as barriers to and facilitators of a preventive intervention for pediatric type 2 diabetes
Creators: name: Hall, William J.
name: Steckler, Allan
name: Hall, John M.
name: Fisher, M. Randall
name: Schneider, Margaret
name: Thompson, Deborah
name: Volpe, Stella L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: School-based interventions are essential to prevent pediatric obesity and type 2 diabetes. School environmental factors influence implementation of these interventions. This article examines how school factors acted as barriers to and facilitators of the HEALTHY intervention. The HEALTHY study was a cluster-randomized trial of a multicomponent intervention implemented in 21 schools. Interview data were analyzed to identify barriers and facilitators. Barriers included teacher frustration that intervention activities detracted from tested subjects, student resistance and misbehavior, classroom management problems, communication equipment problems, lack of teacher/staff engagement, high cost and limited availability of nutritious products, inadequate facility space, and large class sizes. Facilitators included teacher/staff engagement, effective classroom management, student engagement, schools with direct control over food service, support from school leaders, and adequate facilities and equipment. Contextual barriers and facilitators must be taken into account in the design and implementation of school-based health interventions.
An Analysis of Factors Affecting Healthy Food Consumption Intention and Behavior: Focusing on Ginseng and Red Ginseng Products
Creators: name: Ju, Jongyun
name: Ju, Jongyun
Publisher: name: Unknown
Year: 2022
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Healthy Foods
subject: Ginseng·Red Ginseng Product
subject: Hybrid Choice Model

description: This study identifies factors influencing consumer preferences for healthy food with the 2021 Consumer Behavior Survey For Food. Among several foods in this category, we focus on ginseng and red ginseng products to solve the problem of their stagnated demand. The structural equation model and hybrid choice model are utilized to compare factors influencing consumer psychology on the intention to buy and the actual purchase. The results of our structural equation model show that convenience, safety, and health functionality are essential factors for consumers’ buying intentions on healthy food. However, the results of the hybrid choice model indicates that only functionality affects the actual purchase of ginseng and red ginseng products. In contrast, convenience and safety affect the buying of overall healthy food. Thus, it is necessary to promote the functionality of ginseng and red ginseng products, enhance R&D investment in the functionality of ginseng products, and strengthen safety and convenience to beat the intensifying competition with other healthy foods.
Additional file 7 of HIV awareness, pre-exposure prophylaxis perceptions and experiences among people who exchange sex: qualitative and community based participatory study
Creators: name: Kislovskiy, Yasaswi
name: Erpenbeck, Sarah
name: Martina, Jamie
name: Judkins, Courtney
name: Miller, Elizabeth
name: Chang, Judy C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 7.
Gold nanoparticles-based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo modelling of human eye
Creators: name: Asadi, Somayeh
name: Vaez-zade, Mehdi
name: Masoudi, S. Farhad
name: Rahmani, Faezeh
name: Knaup, Courtney
name: Meigooni, Ali S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Medical Physics (physics.med-ph)
subject: FOS: Physical sciences

description: The effects of gold nanoparticles in 125I brachytherapy dose enhancement on choroidal Melanoma are examined using the Monte Carlo simulation technique. Usually, Monte Carlo ophthalmic brachytherapy dosimetry is performed in a water phantom. However, here, the compositions of human eye have been considered instead of water. Both human eye and water phantoms have been simulated with MCNP5 code. These simulations were performed for a fully-loaded 16 mm COMS eye plaque containing 13 125I seeds. The dose delivered to the tumor and healthy tissues have been calculated in both phantoms, with and without GNPs. The results indicates that the dose to the tumor in an eye-ball implanted with COMS plaque increases with increasing GNPs concentration inside the target. Therefore, the required irradiation time for the tumors in the eye is decreased by adding the GNPs prior to treatment. As a result, the dose to healthy tissues decreases when the irradiation time is reduced. Furthermore, a comparison between the simulated data in an eye phantom made of water and eye phantom made of human-eye composition, in the presence of GNPs shows the significance of utilizing the composition of eye in ophthalmic brachytherapy dosimetry. Normally, the radiation therapy of cancer patients is designed to deliver a required dose to the tumor while sparing the surrounding healthy tissues. The results demonstrated that the use of GNPs enable us to overcome this challenge. Also, defining the eye composition instead of water will leads to more accurate calculations of GNPs radiation effects in ophthalmic brachytherapy dosimetry.
Social support for physical activity—role of Facebook with and without structured intervention
Creators: name: Cavallo, David N.
name: Thayer, Linden M.
name: Ammerman, Alice S.
name: Ward, Dianne S.
name: Tate, Deborah F.
name: DeVellis, Robert F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Despite their widespread use and extensive technical features, little is known about how to use online social networking sites to increase physical activity. This study aims to examine Facebook engagement among participants in the online social networking arm of a randomized controlled physical activity promotion trial (n = 67). Facebook communications were double coded and analyzed using ATLAS.ti. Regression procedures were used to determine predictors of Facebook use and associations between types of use and changes in perceived social support and physical activity. Changes in perceived social support and physical activity were more strongly associated with participants' individual Facebook use than use of the Facebook intervention group. The way social media sites are used in intervention design could have an impact on their effects. Including existing friends in interventions and using applications that incorporate intervention activities into a more naturalistic use of Facebook may improve the efficacy of future interventions.
The EARLY trials: a consortium of studies targeting weight control in young adults
Creators: name: Svetkey, Laura P
name: Patrick, Kevin
name: Jakicic, John M
name: Fernandez, I Diana
name: Wing, Rena
name: Belle, Steven H
name: Lytle, Leslie A
name: Olson, Christine M
name: Loria, Catherine M
name: Johnson, Karen C
name: Tate, Deborah F
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Young adulthood has been identified as a high-risk period for the development of obesity but few interventions have been tested in this population. One way to escalate our learning about effective interventions is to test a number of interventions simultaneously as a consortium of research trials. This paper describes the Early Adult Reduction of weight through LifestYle intervention (EARLY) trials. Seven research sites were funded to conduct intervention trials, agreeing to test similar primary outcomes and cooperating to use a set of common measurement tools. The EARLY consortium was able to work cooperatively using an executive committee, a steering committee, workgroups and subcommittees to help direct the common work and implement a set of common protocol and measurement tools for seven independent but coordinated weight-related intervention trials. Using a consortium of studies to help young adults reach or maintain a healthy weight will result in increased efficiency and speed in understanding the most effective intervention strategies.
Translating a health behavior change intervention for delivery to 2-year college students: the importance of formative research
Creators: name: Sevcik, Sarah M
name: Linde, Jennifer A
name: Gardner, Jolynn K
name: Lytle, Leslie A
name: Petrich, Christine A
name: Lozano, Paula
name: Laska, Melissa N
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Young adults are at risk for weight gain in the transition to independent adulthood; 2-year college students are at greater risk and understudied relative to 4-year students. This project conducted formative research for a randomized controlled weight gain prevention trial among 2-year college students, to ensure appropriateness of content and delivery of a curriculum originally developed for 4-year college students. Data were collected from community college students, faculty, and staff from October 2009 to August 2011. Work included focus groups and key informant interviews, curriculum pilot testing, and social network and support website beta testing. Based on focus groups and interviews, program content, course delivery modes, and communication channels were adjusted to meet population interests and preferences. The course was delivered successfully in pilot testing, and the website was received well by beta testers. Formative work successfully guided program adaptations to address population needs.
Background and rationale for the Society of Behavioral Medicine’s position statement: expand United States health plan coverage for diabetes self-management education and support
Creators: name: Gerber, Ben S.
name: Fisher, Edwin B.
name: Sharp, Lisa K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The Society of Behavioral Medicine (SBM) recognizes that diabetes self-management (DSM) education and support are fundamental to teaching people how to manage their diabetes and decrease disease-related complications. Implementation of the Patient Protection and Affordable Care Act provides an opportunity to expand DSM education and support to many people who are currently excluded from such services due to lack of insurance coverage, current policy barriers, or simple failure of healthcare systems to provide them. Extending the range and provision of such services could translate into reduced diabetic complications, a reduction in unnecessary healthcare utilization, and significant health-related cost savings on a national level. SBM recommends that public and private insurers be required to reimburse for 12 h of DSM education and support annually for anyone with diabetes. Further, SBM recognizes that a range of modes and providers of DSM education and support have been shown effective, and that patient preferences and resources may influence choice. To address this, SBM urges health organizations to increase and diversify approaches toward DSM education and support they offer.
Society of Behavioral Medicine position statement: early care and education (ECE) policies can impact obesity prevention among preschool-aged children
Creators: name: Fitzgibbon, Marian L.
name: Ward, Dianne S.
name: Becker, Adam B.
name: Buscemi, Joanna
name: Kanwischer, Katelyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The Society of Behavioral Medicine (SBM) urges policymakers to help prevent childhood obesity by improving state regulations for Early Care and Education (ECE) settings related to child nutrition,...
Improving chemoradiotherapy with nanoparticle therapeutics
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation. Recent development of nanoparticle (NP)-based chemotherapeutics offers a unique opportunity to improve the delivery of chemotherapy, which can in turn improve chemoradiotherapy’s efficacy while lowering toxicity. NP-based chemotherapeutics also possess several characteristics that are well suited for chemoradiotherapy. Therefore, NP chemotherapeutics hold high potential in improving the therapeutic index of chemoradiotherapy. This manuscript reviews the NP properties that are favorable for chemoradiation and the rationale to utilize nanotherapeutics in chemoradiation. This review also discusses the preclinical and clinical data on using NP therapeutics in chemoradiotherapy.
Additional file 1 of Prevalence of S. aureus and/or MRSA from seafood products from Indian seafood products
Creators: name: Sivaraman, Gopalan Krishnan
name: Gupta, Sobin Sonu
name: Visnuvinayagam, S
name: Muthulakshmi, T
name: Elangovan, Ravikrishnan
name: Perumal, Vivekanandan
name: Balasubramanium, Ganesh
name: Lodha, Tushar
name: Yadav, Amit
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1:
Asymptotic Structure of Constrained Exponential Random Graph Models
Creators: name: Zhu, Lingjiong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: In this paper, we study exponential random graph models subject to certain constraints. We obtain some general results about the asymptotic structure of the model. We show that there exists non-trivial regions in the phase plane where the asymptotic structure is uniform and there also exists non-trivial regions in the phase plane where the asymptotic structure is non-uniform. We will get more refined results for the star model and in particular the two-star model for which a sharp transition from uniform to non-uniform structure, a stationary point and phase transitions will be obtained.
description: 19 pages, 1 figure
title: Untersuchung des Gehalts und der Qualität von ätherischem Öl in verschiedenen Produkten
Creators: name: Abdul-Ghafor, Saly
Year: 2022

description: Diese Studie wurde durchgeführt, um die flüchtigen Bestandteile von Mentha X piperita und Lavendula angustifolia in Tees und in reinen ätherischen Ölen zu untersuchen. Die verschiedenen Produkte wurden in einer Apotheke und einem Supermarkt gekauft.
description: This study was conducted to investigate the volatile components of Mentha X piperita and Lavendula angustifolia in teas and in pure essential oils. The different products were purchased from a pharmacy and a supermarket.
Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate Cancer
Creators: name: Mehedint, Diana C.
name: Wrzosek, Carol S.
name: Mohler, James L.
name: Li, Yun
name: Singh, Swaroop S.
name: Titus, Mark A.
name: Ford, Oscar Harris
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors but not in regressed tumors. The objectives of this study were to develop an immunostaining method to dual-label foci of proliferating tumor cells [the origin of castration-recurrent CaP (CR-CaP)], to determine which of the nine candidate proteins were differentially expressed in proliferating versus nonproliferating cells at the onset of growth after castration, and to test preclinical findings using clinical specimens of androgen-stimulated benign prostate (AS-BP) and CaP (AS-CaP) and CR-CaP.
Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo
Creators: name: Setola, V
name: Roth, B L
name: Allen, J A
name: Farrell, M
name: Yadav, P N
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Caveolin-1 (Cav-1) is a scaffolding protein important for regulating receptor signaling cascades by partitioning signaling molecules into membrane microdomains. Disruption of the CAV1 gene has recently been identified as a rare structural variant associated with schizophrenia. Although Cav-1 knockout (KO) mice displayed no baseline behavioral disruptions, Cav-1 KO mice, similar to schizophrenic individuals, exhibited increased sensitivity to the psychotomimetic N-methyl--aspartate receptor antagonist phencyclidine (PCP). Thus, PCP disruption of prepulse inhibition (PPI) and PCP-induced mouse locomotor activity were both enhanced by genetic deletion of Cav-1. Interestingly, genetic deletion of Cav-1 rendered the atypical antipsychotics clozapine and olanzapine and the 5-HT2A-selective antagonist M100907 ineffective at normalizing PCP-induced disruption of PPI. We also discovered that genetic deletion of Cav-1 attenuated 5-HT2A-induced c-Fos and egr-1 expression in mouse frontal cortex and also reduced 5-HT2A-mediated Ca2+ mobilization in primary cortical neuronal cultures. The behavioral effects of the 5-HT2A agonist (2,5-dimethoxy-4-iodoamphetamine) including head twitch responses and disruption of PPI were also attenuated by genetic deletion of Cav-1, indicating that Cav-1 is required for both inverse agonist (that is, atypical antipsychotic drug) and agonist actions at 5-HT2A receptors. This study demonstrates that disruption of the CAV1 gene—a rare structural variant associated with schizophrenia—is not only pro-psychotic but also attenuates atypical antipsychotic drug actions.
Weyl Superfluidity in a Three-dimensional Dipolar Fermi Gas
Creators: name: Liu, Bo
name: Li, Xiaopeng
name: Yin, Lan
name: Liu, W. Vincent
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Weyl superconductivity or superfluidity, a fascinating topological state of matter, features novel phenomena such as emergent Weyl fermionic excitations and anomalies. Here we report that an anisotropic Weyl superfluid state can arise as a low temperature stable phase in a 3D dipolar Fermi gas. A crucial ingredient of our model is a rotating external field that generates a direction-dependent two-body effective attraction. Experimental signatures are predicted for cold gases in radio-frequency spectroscopy. The finite temperature phase diagram of this system is studied and the transition temperature of the Weyl superfluidity is found to be within the experimental scope for atomic dipolar Fermi gases.
description: 6 pages, 5 figures, presentation improved, version as accepted by Phys. Rev. Lett
Analysis of Asymmetric Price Transmission and Market Power of the U.S. Grain Export Market: Focused on Korea and Japan
Creators: name: Seung, Junho
name: Seung, Junho
Publisher: name: Unknown
Year: 2022
Subjects: subject: International Relations/Trade
subject: Marketing
subject: FOS: Economics and business
subject: asymmetric price transmission
subject: nonlinear autoregressive distributed lag model
subject: market power

description: Korea and Japan rely on imports for most of the grain except rice, and the U.S. has maintained the highest shares of wheat, corn, and soybean import markets in both countries. This study aims to analyze the existence of asymmetric price transmission and market power that could occur in the U.S. grain export process targeting Korea and Japan. The results of asymmetric price transmission analysis using a nonlinear ARDL model show that, in the long run, when domestic prices (received by farmers) of wheat, corn, and soybeans in the U.S. increase, the impact on export prices to Korea and Japan is greater than when they decrease. Through the long-run asymmetry test, it was confirmed that there was statistically significant positive asymmetry in the domestic and export price transmissions of wheat, corn, and soybeans in the U.S. Also, in the short run, it was found that there is a positive asymmetry in the domestic and export prices of wheat and corn. Therefore, it is necessary to strengthen the monitoring of domestic and export prices of the U.S. to eliminate asymmetric price transmission. According to the result of the residual demand model estimation, residual demand elasticity was negative and statistically significant only in the case of corn and soybeans of Japan. In other words, it was found that the U.S. has market power in the corn and soybean import market of Japan, which is highly dependent on imports compared to Korea, but does not have market power in the Korean market. This suggests that, unlike Japan, in Korea's grain import market, there is a competitive structure between the U.S. and other exporting countries.
The thermodynamics of creating correlations: Limitations and optimal protocols
Creators: name: Bruschi, David Edward
name: Perarnau-Llobet, Martí
name: Friis, Nicolai
name: Hovhannisyan, Karen V.
name: Huber, Marcus
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We establish a rigorous connection between fundamental resource theories at the quantum scale. Correlations and entanglement constitute indispensable resources for numerous quantum information tasks. However, their establishment comes at the cost of energy, the resource of thermodynamics, and is limited by the initial entropy. Here, the optimal conversion of energy into correlations is investigated. Assuming the presence of a thermal bath, we establish general bounds for arbitrary systems and construct a protocol saturating them. The amount of correlations, quantified by the mutual information, can increase at most linearly with the available energy, and we determine where the linear regime breaks down. We further consider the generation of genuine quantum correlations, focusing on the fundamental constituents of our universe: fermions and bosons. For fermionic modes, we find the optimal entangling protocol. For bosonic modes, we show that while Gaussian operations can be outperformed in creating entanglement, their performance is optimal for high energies.
description: 12 pages, 6 figures
The Subsurface Drainage Facility Project: Performance Evaluation and Economic Feasibility
Creators: name: Lee, Jungmin
name: Lee, Jungmin
Publisher: name: Unknown
Year: 2022
Subjects: subject: Public Economics
subject: drainage improvement project
subject: subsurface drainage facilities
subject: project evaluation

description: This study aimed to find an effective and efficient direction for future projects through the performance evaluation of the drainage improvement project. To achieve the goal, it analyzed the effects on rice production and welfare after the drainage improvement project was administered by the Korea Rural Community Corporation (KRC) by applying the difference in differences (DID) estimation method and an equilibrium displacement model (EDM). Primarily, this study focused on subsurface drainage facilities’ effects on production, which consisted of an increase in yields and a decrease in the time of operating agricultural machines. The analysis result showed that the amount of yields increased by 18.75kg/10a, while machine operation decreased by 6.61 min./10a after the implementation of the project. We found that these effects were reduced when the slope of a field increased or a drainage grade deteriorated. We also discovered that the producer surplus increased by 3,129.9 million won due to a change in the equilibrium of regional rice market affected by the project for 30 years. We calculated the net benefit to be 279.9 million won. The net profit increased when project target areas were selected in consideration of a drainage class and a slope degree. The level of increase in net profit was higher when considering the drainage class than the slope. The results implied that the drainage class is relatively more significant than the slope among the criteria for selecting project target areas to improve project effectiveness.
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
Creators: name: Middeldorp, C M
name: Lin, P
name: Terracciano, A
name: Nyholt, D R
name: Realo, A
name: Gordon, S D
name: Sullivan, P F
name: Ripke, S
name: Grucza, R A
name: Krueger, R F
name: Amin, N
name: de Geus, E J C
name: Esko, T
name: Costa, P T
name: Tanaka, T
name: Heath, A C
name: Spinhoven, P
name: Uda, M
name: Derringer, J
name: Madden, P A F
name: de Moor, M H M
name: Allik, J
name: Agrawal, A
name: Hottenga, J-J
name: Sanna, S
name: Willemsen, G
name: Widen, E
name: Distel, M A
name: Pergadia, M L
name: McGrath, L M
name: Blackwood, D H
name: Hartman, C A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13 835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case–Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ∼0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other.
Indización de documentos según Metodología LILACS 2017: 09 - Indización de estudios en Epidemiología
Creators: name: BIREME/OPS/OMS
name: Conceição, Maria Anália da
name: Suga, Sueli Mitiko Yano
Publisher: name: Zenodo
Year: 2017
Subjects: subject: Indizacion de documentos
subject: Metodologia LILACS
subject: https://decs.bvsalud.org/ths/resource/?id=56243
subject: https://decs.bvsalud.org/ths/resource/?id=46

description: Sesión 9 | 30 de Noviembre de 2017 Tema: Estudios de Epidemiología Grupo Red BVS: https://groups.google.com/forum/#!topic/red-bvs/
Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome
Creators: name: Schoch, K
name: Hooper, S R
name: Ip, E H
name: Shashi, V
name: Howard, T D
name: Keshavan, M S
name: Bernal, A J
name: Jirtle, R L
name: Chakraborty, D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Chromosome 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion syndrome in humans. It is typified by highly variable symptoms, which might be explained by epigenetic regulation of genes in the interval. Using computational algorithms, our laboratory previously predicted that DiGeorge critical region 6 (DGCR6), which lies within the deletion interval, is imprinted in humans. Expression and epigenetic regulation of this gene have not, however, been examined in 22q11DS subjects. The purpose of this study was to determine if the expression levels of DGCR6 and its duplicate copy DGCR6L in 22q11DS subjects are associated with the parent-of-origin of the deletion and childhood psychopathologies. Our investigation showed no evidence of parent-of-origin-related differences in expression of both DGCR6 and DGCR6L. However, we found that the variability in DGCR6 expression was significantly greater in 22q11DS children than in age and gender-matched control individuals. Children with 22q11DS who had anxiety disorders had significantly lower DGCR6 expression, especially in subjects with the deletion on the maternal chromosome, despite the lack of imprinting. Our findings indicate that epigenetic mechanisms other than imprinting contribute to the dysregulation of these genes and the associated childhood psychopathologies observed in individuals with 22q11DS. Further studies are now needed to test the usefulness of DGCR6 and DGCR6L expression and alterations in the epigenome at these loci in predicting childhood anxiety and associated adult-onset pathologies in 22q11DS subjects.
Nanoscale Electrostatic Control of Oxide Interfaces
Creators: name: Goswami, Srijit
name: Mulazimoglu, Emre
name: Vandersypen, Lieven M. K.
name: Caviglia, Andrea D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We develop a robust and versatile platform to define nanostructures at oxide interfaces via patterned top gates. Using LaAlO$_3$/SrTiO$_3$ as a model system, we demonstrate controllable electrostatic confinement of electrons to nanoscale regions in the conducting interface. The excellent gate response, ultra-low leakage currents, and long term stability of these gates allow us to perform a variety of studies in different device geometries from room temperature down to 50 mK. Using a split-gate device we demonstrate the formation of a narrow conducting channel whose width can be controllably reduced via the application of appropriate gate voltages. We also show that a single narrow gate can be used to induce locally a superconducting to insulating transition. Furthermore, in the superconducting regime we see indications of a gate-voltage controlled Josephson effect.
description: Version after peer review; includes additional data on superconductivity
Genome-wide meta-analyses of smoking behaviors in African Americans
Creators: name: Chen, G K
name: Bandera, E V
name: Chanock, S J
name: Blot, W J
name: Wessel, J
name: Deming, S L
name: Eaton, C B
name: Hamidovic, A
name: Buxbaum, S G
name: Nalls, M A
name: Bernstein, L
name: Diver, W R
name: Kasberger, J L
name: Ambrosone, C B
name: Thacker, E L
name: Becker, L
name: Broeckel, U
name: Tranah, G J
name: Sung, Y J
name: Bergen, A W
name: Brown, W M
name: Caporaso, N
name: Kim, Y
name: Evans, M K
name: Arnett, D
name: Berndt, S I
name: Fornage, M
name: Petruzella, S
name: Becker, D M
name: Casey, G
name: David, S P
name: Evans, D S
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n=32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (β=0.040, s.e.=0.007, P=1.84 × 10−8). This variant is present in the 5′-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans.
A meta-analysis of gene expression quantitative trait loci in brain
Creators: name: van den Oord, E
name: Kim, Y
name: Tao, R
name: Vladimirov, V
name: Sullivan, P F
name: Xia, K
name: Giusti-Rodriguez, P
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Current catalogs of brain expression quantitative trait loci (eQTL) are incomplete and the findings do not replicate well across studies. All existing cortical eQTL studies are small and emphasize the need for a meta-analysis. We performed a meta-analysis of 424 brain samples across five studies to identify regulatory variants influencing gene expression in human cortex. We identified 3584 genes in autosomes and chromosome X with false discovery rate q<0.05 whose expression was significantly associated with DNA sequence variation. Consistent with previous eQTL studies, local regulatory variants tended to occur symmetrically around transcription start sites and the effect was more evident in studies with large sample sizes. In contrast to random SNPs, we observed that significant eQTLs were more likely to be near 5'-untranslated regions and intersect with regulatory features. Permutation-based enrichment analysis revealed that SNPs associated with schizophrenia and bipolar disorder were enriched among brain eQTLs. Genes with significant eQTL evidence were also strongly associated with diseases from OMIM (Online Mendelian Inheritance in Man) and the NHGRI (National Human Genome Research Institute) genome-wide association study catalog. Surprisingly, we found that a large proportion (28%) of ~1000 autosomal genes encoding proteins needed for mitochondrial structure or function were eQTLs (enrichment P-value=1.3 × 10−9), suggesting a potential role for common genetic variation influencing the robustness of energy supply in brain and a possible role in the etiology of some psychiatric disorders. These systematically generated eQTL information should be a valuable resource in determining the functional mechanisms of brain gene expression and the underlying biology of associations with psychiatric disorders.