cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Operative Behandlungsmöglichkeiten und anatomische Einflussfaktoren bei Patienten mit degenerativer Spinalkanalstenose
Creators: name: Bayerl, Simon Heinrich
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Claudiactio Spinalis
subject: Pelvic Incidence
subject: Pelvic Tilt
subject: Sacral Slope
subject: Lumbar Lordosis
subject: Myelopathy
subject: Sagittal Profile
subject: Sagittales Profil
subject: Spinal Stenosis
subject: Sagittale Balance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In dieser Habilitationsschrift wurden unterschiedliche operative Behandlungsmöglichkeiten und anatomische Einflussfaktoren bei Patient*innen mit degenerativer Spinakanalstenose untersucht. Es konnten die Chancen und Risiken unterschiedlicher ventraler Oprationstechniken an der Halswirbelsäule dargestellt werden. Hierbei konnte zunächst ein gutes operatives Resultat bei der ventralen Fusion durch intervertebrale Cages oder durch einen Wirbelkörperersatz bestätigt werden, es zeigte sich jedoch, dass bei der 2-Höhen-Korporektomie die postoperative Komplikationsrate durch eine sekundäre Instabilität sehr hoch war. Diese Komplikation konnte durch eine zusätzliche dorsale Instrumentierung verhindert werden. Die klinischen Ergebnisse nach einer mikrochirurgischen Dekompression bei Patient*innen mit lumbaler Spinalknalstenose waren wie in vorausgehenden Studien gut. Es konnte zudem gezeigt werden, dass durch eine operative Dekompression bei Patient*innen mit einer durch epidurale Lipomatose entstandenen Spinalkanalstenose ein gutes Langzeitergebnis erzielt werden kann. Wider Erwarten hatte die präoperative Sagittale Balance keinen signifikanten Einfluss auf den klinischen Verlauf von Patient*innen mit lumbaler Spinalknalstenose nach mikrochirurgischem Eingriff. Relevant für das postoperative Ergebnis war vielmehr das Sagittale Profil. Insbesondere Patient*innen mit einer ausgeprägten und kurzen lumbalen Lordose und vermehrter Belastung auf den dorsalen Strukturen der Lendenwirbelsäule durch eine langstreckige thorakolumbale Kyphose litten im postoperativen Verlauf unter starken Lumbalgien. Bei diesen Patient*innen sollte über alternative Behandlungsmöglichkeiten nachgedacht werden.
The functional and clinical outcomes of exercise training following a very low energy diet for severely obese women: Study protocol for a randomised controlled trial
Creators: name: Miller, Clint T.
name: Fraser, Steve F.
name: Selig, Steve E.
name: Rice, Toni
name: Grima, Mariee
name: Straznicky, Nora E.
name: Levinger, Itamar
name: Lambert, Elisabeth
name: van den Hoek, Daniel J.
name: Dixon, John B.
Publisher: name: Swinburne
Year: 2024

description: Background: Clinical practice guidelines globally recommend lifestyle modification including diet and exercise training as first-line treatment for obesity. The clinical benefits of exercise training in adults with obesity is well-documented; however, there is no strong evidence for the effectiveness of exercise training for weight loss in class II and class III obesity. The purpose of the randomised controlled trial described in this protocol article is to examine the effect of exercise training, in addition to a very low energy diet (VLED), in clinically severe obese women for changes in body composition, physical function, quality of life, and markers of cardiometabolic risk. Methods/Design: Sixty women, aged 18–50 years with a body mass index (BMI) greater than 34.9 kg.m2 and at least one obesity-related co-morbidity, will be recruited for this 12-month study. Participants will be randomised to either exercise plus energy restriction (n = 30), or energy restriction alone (n = 30). All participants will follow an energy-restricted individualised diet incorporating a VLED component. The exercise intervention group will also receive exercise by supervised aerobic and resistance training and a home-based exercise programme totalling 300 minutes per week. Primary outcome measures include body composition and aerobic fitness. Secondary outcome measures include: physical function, cardiometabolic risk factors, quality of life, physical activity, and mental health. All outcome measures will be conducted at baseline, 3, 6 and 12 months. Discussion: Previous research demonstrates various health benefits of including exercise training as part of a healthy lifestyle at all BMI ranges. Although clinical practice guidelines recommend exercise training as part of first-line treatment for overweight and obesity, there are few studies that demonstrate the effectiveness of exercise in class II and class III obesity. The study aims to determine whether the addition of exercise training to a VLED provides more favourable improvements in body composition, physical function, quality of life, and markers of cardiometabolic risk for women with clinically severe obesity, compared to VLED alone.
Sub specie aeterni: The mystical in the early writings of Ludwig Wittgenstein
Creators: name: Atkinson, James
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Philosophy.

description: The aim of this thesis is to consider what reasonably follows from the hypothesis that the Tractatus Logico-Philosophicus can be interpreted from a mystical point of view. That is, if the final passages on the mystical are considered as the conclusion of the book, how does this end follow from Ludwig Wittgenstein's claim that the Tractatus deals with the problems of philosophy? First, I will attempt to show that Russell's method based on analysis is an inadequate means of understanding what cannot be put into words. Second, in contrast to analysis, I will consider the method Wittgenstein uses in light of the topics in the Tractatus that cannot be expressed in words. This second point is the focus of this project because, as I will show, while reality cannot be expressed in words, neither can it be considered nonsense. Next, the thesis will examine the question of showing in three parts. First, it will demonstrate that Wittgenstein's notion of showing forms the basis for his separation from Russell's theory of types; second, it will illustrate that there is no distinction between what is shown and what shows itself, and third, it will connect Wittgenstein's notion of showing to the mystical. Following this, the thesis is concerned with what sense we can grasp of what cannot be put into words. In dealing with the eternal and the mystical, this section will offer a view from outside language to satisfy both concerns (i.e. both reality and what cannot be expressed in words). Viewing the world in this way is the mystical. Finally, we will discuss sense and nonsense, and the mystical from the view of other philosophers in order to show that Wittgenstein's thoughts on nonsense and the mystical cannot be interpreted from either a metaphysical point of view or an anti-metaphysical perspective.
Persistent weight loss with a non-invasive novel medical device to change eating behaviour in obese individuals with high-risk cardiovascular risk profile
Creators: name: Seck, Peter Von
name: Sander, F. Martin
name: Lanzendorf, Leon
name: Seck, Sabine Von
name: Schmidt-Lucke, Andre
name: Zielonka, Mirja
name: Schmidt-Lucke, Caroline
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In evidence-based weight-loss programs weight regain is common after an initial weight reduction. Eating slowly significantly lowers meal energy intake and hunger ratings. Despite this knowledge, obese individuals do not implement this behaviour. We, thus tested the hypothesis of changing eating behaviour with an intra-oral medical device leading to constant weight reduction in overweight and obesity. Six obese patients (6 men, age 56 ± 14, BMI 29 ± 2 kg / m2) with increased CVRF profile were included in this prospective study. All patients had been treated for obesity during the last 10 years in a single centre and had at least 3 frustrate evidence-based diets. Patients received a novel non-invasive intra-oral medical device to slow eating time. Further advice included not to count calories, to avoid any other form of diet, to take their time with their meals, and to eat whatever they liked. This device was used only during meals for the first 4 to 8 weeks for a total of 88 [20–160] hours. Follow-up period was 23 [15–38] months. During this period, patients lost 11% [5–20%] (p<0.001) of their initial weight. At 12 months, all patients had lost >5%, and 67% (4/6) achieved a >10% bodyweight loss. In the course of the study, altered eating patterns were observed. There were no complications with the medical device. Of note, all patients continued to lose weight after the initial intervention period (p<0.001) and none of them had weight regain. With this medical device, overweight and obese patients with a history of previously frustrating attempts to lose weight achieved a significant and sustained weight loss over two years. These results warrant the ongoing prospective randomised controlled trial to prove concept and mechanism of action. Trial registration: German Clinical Trials Register DRKS0001135
Objektivierung von funktionellen und strukturellen Beeinträchtigungen sensorischer Afferenzen bei neuroimmunologischen Krankheitsbildern
Creators: name: Schmidt, Felix Alexander
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Olfactory Dysfunction
subject: Neuroimmunology
subject: Sensorische Afferenzstörungen
subject: Multiple Sklerose
subject: Neuromyelitis Optica
subject: Autoimmunenzephalitis
subject: relative afferent pupillary defect
subject: B-mode Ultrasound
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In dieser kumulativen Habilitationsschrift werden eigene Arbeiten zusammengefasst, die sich thematisch mit der Objektivierung sensorischer Afferenzstörungen bei neuroimmunologischen Krankheitsbildern befassen. B-mode Ultraschall, eine in der klinischen Routine weit verbreitete Methode, wurde als objektives Untersuchungsverfahren zur Beurteilung der Pupillenfunktion etabliert, Normwerte von Pupillendurchmessern und Pupillenkonstriktionszeiten wurden für verschiedene Altersgruppen publiziert. Das frühzeitige Erkennen und Behandeln einer ON ist entscheidend, um irreversible Schäden des N. opticus zu verhindern. Eine Funktionsstörung des afferenten visuellen Systems bei Patienten mit ON ließ sich gut mittels B-mode Ultraschall objektivieren und quantifizieren. B-mode Ultraschall könnte als bildgebender Biomarker für ein RAPD und als Surrogat-Parameter für eine Läsion des N. opticus in klinischen Studien und in der Routinediagnostik Anwendung finden. In einer weiteren Studie wurde die visuelle Lebensqualität bei NMOSD und MS Patienten mit Zustand nach ON untersucht. Die Einschränkung an visueller Lebensqualität korrelierte mit dem Ausmaß an funktioneller und struktureller Schädigung des afferenten visuellen Systems, gemessen mittels OCT und Visus. Die Integrität des afferenten olfaktorischen Systems wurde bei der NMOSD, PPMS und AE in eigenen Arbeiten erstmals untersucht. Zusammenfassend erwies sich das Riechvermögen bei diesen seltenen neuroimmunoloigschen Krankheitsbildern als deutlich eingeschränkt, wobei wir dabei von unterschiedlichen Pathomechanismen ausgehen. Riechstörungen sind möglicherweise ein weiteres Symptom dieser phänotypisch sehr heterogenen Krankheitsbilder. Eine niederschwellige Riechtestung im Rahmen der differentialdiagnostischen Zuordnung sollte bei den untersuchten Krankheitsbildern in Erwägung gezogen werden.
Low-dose Anti-thymocyte Globulin Inhibits Human B-cell Differentiation into Antibody-Secreting Cells
Creators: name: Klaus, Pascal
name: Heine, Guido
name: Rasche, Claudia
name: Worm, Margitta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Anti-thymocyte globulin (ATG) is used in the treatment of acute organ rejection. We studied in vitro the effect of low-dose ATG on B-cell activation and differentiation to antibody-secreting cells, as this may have an effect on B cell-driven autoimmune diseases, such as pemphigus vulgaris. Immunoglobulin production was analysed in the supernatants of peripheral blood mononuclear cells (PBMC) and CD19+ B cells from healthy donors and from patients with different autoimmune diseases. B-cell proliferation, viability and differentiation were analysed using flow cytometry. Differentiation of B cells to immunoglobulin G (IgG) secreting cells was significantly reduced by ATG, but not by control unspecific IgG from non-immunized rabbits (rIgG). B-cell viability was not altered by sub-depleting concentrations of ATG. In contrast, B-cell proliferation was enhanced by ATG. When PBMC from patients with autoimmune diseases were studied, specific autoantibodies could be detected in 1 out of 10 patients. In this patient, who had pemphigus vulgaris, ATG not only decreased total IgG, but decreased also specific anti-desmoglein-3. In conclusion, these data suggest that ATG at low concentrations inhibits B-cell differentiation and function.
Improving the Short-Range Perception of MIMO Radars with LO Feedthrough Topologies by Complex Sampling
Creators: name: Schwarz, Dominik
name: Riese, Nico
name: Dorsch, Ines
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Automotive Radar
subject: Chirp Sequence Modulation
subject: Direction-Of-Arrival Estimation
subject: Frequency Modulated Continuous Wave
subject: Imaging Radar
subject: Local Oscillator Feedthrough
subject: mm-Wave
subject: Multiple-Input Multiple-Output
subject: DDC 620 / Engineering & allied operations
subject: MIMO systems
subject: FMCW-Radar

description: In radar systems with local oscillator feedthrough topology, range shifts occur due to the time delays between the radar transceivers. These shifts can be corrected efficiently in postprocessing, except for the short-range spectrum, as disturbing peaks, caused by range shifts of the transmit-to-receive leakage, prevent the use of such system in short-range applications like automated parking. In this contribution, the capabilities of complex sampling, compared to real sampling, are analyzed both in theory and by measurements, with respect to the effects in systems with feedthrough topology. The imaging performance at very short ranges is investigated with an exemplary scenario, representing a typical automated parking situation. The measurements show that with complex sampling, the image peaks vanish and the noise level is reduced by 2.8 dB. In this way, radar images suitable for automated parking and other short range applications can be obtained.
description: Bei Radarsystemen mit LO-Feedthrough Topologie kommt es aufgrund der Zeitverzögerungen zwi-schen den Radar-Transceivern zu Entfernungsverschiebungen. Diese Verschiebungen können im Post-processing effizient korrigiert werden – mit Ausnahme des Nahbereichsspektrums, da störende Spit-zen, die durch Entfernungsverschiebungen des Tx-Rx Leakage verursacht werden, den Einsatz eines solchen Systems in Nahbereichsanwendungen wie dem automatischen Parken verhindern. In diesem Beitrag werden die Möglichkeiten der komplexen Abtastung im Vergleich zur reellen Abtastung sowohl in der Theorie als auch durch Messungen analysiert, und zwar im Hinblick auf die Auswirkungen in Sys-temen mit LO-Feedthrough Topologie. Die Qualität der Bildgebung bei sehr kurzen Entfernungen wird anhand eines beispielhaften Szenarios untersucht, das eine typische Situation beim automatisierten Parken darstellt. Die Messungen zeigen, dass bei komplexer Abtastung die Geisterziele verschwinden und der Rauschpegel um 2,8 dB reduziert wird. Auf diese Weise können Radarbilder gewonnen wer-den, die für automatisiertes Parken und andere Anwendungen im Nahbereich geeignet sind.
Supplementary document for Structuring ray-wave vector vortex light in multiple degrees of freedom - 4607493.pdf
Creators: name: Shen, Yijie
name: Yang, Xilin
name: Naidoo, Darryl
name: Fu, Xing
name: Forbes, Andrew
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Lasers and Quantum Electronics
Classical and Physical Optics

description: Supplemental document
Interactions of malpighian tubules of the tobacco hornworm (Manduca sexta) with P-glycoprotein substrates.
Creators: name: Gaertner, Lorin S.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Entomology.

description: I examined transport characteristics of isolated Malpighian (excretory) tubules from the tobacco hornworm (Manduca sexta), a Lepidopteran which tolerates high levels of dietary nicotine, to test the hypothesis that alkaloid (e.g. nicotine) transport in the tubules is the consequence of a multidrug transport system similar to that mediated by P-glycoprotein in multidrug resistant cancer cells. P-glycoprotein substrates were applied to the basal (blood) side of the tubule and their subsequent distribution monitored. First, using cannulated tubules in a modification of the Ramsay assay, [3H]-vinblastine levels were measured in samples of bathing and luminal solutions. After 1 h, the tubules had concentrated vinblastine in the lumen 3-fold (from 1 muM). This accumulation was independent of a transepithelial potential, and was inhibited by verapamil, a P-glycoprotein inhibitor, and by nicotine. Second, fluorescent drugs, including daunomycin, rhodamine 123 and acridine orange, were applied to living tubules in a well of saline on a coverslip and examined by confocal microscopy. All of these drugs stained the cells of the tubule within 1 min, but, contrary to expectation, none of the drugs appeared in the lumen even after 1--2 h of incubation. Neither verapamil nor nicotine altered the pattern of daunomycin staining. The fast and intense Malpighian tubule staining was in sharp contrast to that of other tissues, which (for most drugs) stained lightly and only after prolonged exposures. Fluid-phase markers appeared to penetrate the tissue, but more slowly, and remained largely extracellular. The results suggest that the Malpighian tubule clears hemolymph of xenobiotics by passive filtration, active transepithelial transport involving a P-glycoprotein-like pump which handles alkaloids, and a scavenger-like absorption of compounds.
LPS promotes resistance to TRAIL-induced apoptosis in pancreatic cancer
Creators: name: Beyer, Katharina
name: Partecke, Lars Ivo
name: Roetz, Felicitas
name: Fluhr, Herbert
name: Weiss, Frank Ulrich
name: Heidecke, Claus-Dieter
name: Von Bernstorff, Wolfram
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: TRAIL
subject: LPS
subject: Pancreas cancer
subject: Apoptosis
subject: Cell lines
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Though TRAIL has been hailed as a promising drug for tumour treatment, it has been observed that many tumour cells have developed escape mechanisms against TRAIL-induced apoptosis. As a receptor of LPS, TLR 4, which is expressed on a variety of cancer cells, can be associated with TRAIL- resistance of tumour cells and tumour progression as well as with the generation of an anti-tumour immune response. Methods In this study, the sensitivity to TRAIL-induced apoptosis as well as the influence of LPS-co- stimulation on the cell viability of the pancreatic cancer cell lines PANC-1, BxPC-3 and COLO 357 was examined by FACS analyses and a cell viability assay. Subsequently, the expression of TRAIL-receptors was detected via FACS analyses. Levels of osteoprotegerin (OPG) were also determined using an enzyme-linked immunosorbent assay. Results PANC-1 cells were shown to be resistant to TRAIL-induced apoptosis. This was accompanied by significantly increased osteoprotegerin levels and a significantly decreased expression of DR4. In contrast, TRAIL significantly induced apoptosis in COLO 357 cells and to a lesser degree in BxPC-3 cells. Co-stimulation of COLO 357 as well as BxPC-3 cells combining TRAIL and LPS resulted in a significant decrease in TRAIL-induced apoptosis. In COLO 357 cells TRAIL-stimulation decreased the levels of OPG thereby not altering the expression of the TRAIL-receptors 1–4 resulting in a high susceptibility to TRAIL-induced apoptosis. Co-stimulation with LPS and TRAIL completely reversed the effect of TRAIL on OPG levels reaching a 2-fold increase beyond the level of non-stimulated cells resulting in a lower susceptibility to apoptosis. In BxPC-3, TRAIL stimulation decreased the expression of DR4 and significantly increased the decoy receptors TRAIL-R3 and TRAIL-R4 leading to a decrease in TRAIL-induced apoptosis. OPG levels remained unchanged. Co-stimulation with TRAIL and LPS further enhanced the changes in TRAIL-receptor-expression promoting apoptosis resistance. Conclusions Here it has been shown that TRAIL-resistance in pancreatic cancer cells can be mediated by the inflammatory molecule LPS as well as by different expression patterns of functional and non-functional TRAIL-receptors.
High-Gain Holographic Multi-Feed Antenna
Creators: name: Döring, Maximilian
name: Frey, Thomas
name: Waldschmidt, Christian
name: Chaloun, Tobias
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: holographic antenna
subject: multi-feed antenna
subject: high gain
subject: DDC 620 / Engineering & allied operations
subject: Leaky-wave antennas
subject: Antenne

description: In this work, a novel multi-feed synthesis for holographic leaky-wave (LW) antennas is presented that considers the angular dependence of each pixel structure. This approach of combining multiple single-beam holograms minimizes the impedance error w.r.t. each individual impedance hologram. A multi-feed antenna with two feeding points at 20GHz is fabricated and measured using this new design methodology. The simulation and measurement results show a good agreement. The fabricated LW antenna has a gain of 21.7 dBi and 22.1 dBi and a side lobe level (SLL) of 9.0 dB and 9.6 dB for both feeds.
Research report 2017 part I
Creators: name: Korth, Martin
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Universities; Germany; Ulm
subject: Research Ulm
subject: DDC 540 / Chemistry & allied sciences
subject: Universities and colleges; Germany
subject: Theoretical chemistry; Research
subject: Universität Ulm
subject: Theoretische Chemie
subject: Forschung

description: This report gives an overview of research in the Korth group at Ulm University in 2017.
The SAMI Galaxy Survey: Mass as the Driver of the Kinematic Morphology-Density Relation in Clusters
Creators: name: Brough, Sarah
name: Van De Sande, Jesse
name: Owers, Matt S.
name: D'Eugenio, Francesco
name: Sharp, Rob
name: Cortese, Luca
name: Scott, Nicholas
name: Croom, Scott M.
name: Bassett, Robert
name: Bekki, Kenji
name: Bland-Hawthorn, Joss
name: Bryant, Julia J.
name: Davies, Roger
name: Drinkwater, Michael J.
name: Driver, Simon P.
name: Foster, Caroline
name: Goldstein, Gregory
name: López-Sánchez, R.
name: Medling, Anne M.
name: Sweet, Sarah
name: Taranu, Dan S.
name: Tonini, Chiara
name: Yi, Sukyoung K.
name: Goodwin, Michael
name: Lawrence, J. S.
name: Richards, Samuel N.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We examine the kinematic morphology of early-type galaxies (ETGs) in eight galaxy clusters in the Sydney-AAO Multi-object Integral field spectrograph (SAMI) Galaxy Survey. The clusters cover a mass range of 14.2〈log(M_200/M_sun)〈15.2 and we measure spatially-resolved stellar kinematics for 293 cluster members within 1R_200 of the cluster centers. We calculate the spin parameter, lambda_R for these galaxies and use that to classify the kinematic morphology of the galaxies as fast (high spin parameter) or slow (low spin parameter) rotators. The total fraction of slow rotators in the early-type galaxy population, F_SR=0.14+/-0.02 and does not depend on host cluster mass. Across the eight clusters, the fraction of slow rotators increases with increasing local environmental overdensity. We also find that the slow-rotator fraction increases at small clustercentric radii (R_cl〈0.3R_200), and note that there is also an enhancement in slow-rotator fraction at R_cl~0.6R_200 in cluster substructure. We find the strongest increase in slow-rotator fraction occurs with increasing stellar mass. After accounting for the strong correlation with stellar mass, we find no significant relationship between spin parameter and local overdensity in the cluster environment. We therefore conclude that the primary driver for the kinematic morphology--density relationship in galaxy clusters is the changing distribution of galaxy stellar mass with local environment. The presence of slow rotators in cluster substructure suggests that the cluster kinematic morphology--density relationship is a result of mass segregation of slow-rotating galaxies forming in galaxy groups that later merge with clusters and sink to the cluster center via dynamical friction.
title: Diagnóstico diferencial de lesiones benignas maxilares y mandibulares.
Creators: name: Ubeda Morant, Nuria
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Head and neck
subject: CT
subject: Conventional radiography

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir que lesiones benignas pueden afectar al maxilar y a la mandíbula explicando su origen,
hallazgos por imagen y claves para el diagnóstico diferencial.
Recordar qué información debe aportar nuestro informe radiológico al especialista en...
Supplementary document for Structuring ray-wave vector vortex light in multiple degrees of freedom - 4607493.pdf
Creators: name: Shen, Yijie
name: Yang, Xilin
name: Naidoo, Darryl
name: Fu, Xing
name: Forbes, Andrew
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Lasers and Quantum Electronics
Classical and Physical Optics

description: Supplemental document
Identifizierung und Validierung von Biomarkern für postoperative Komplikationen nach Nierentransplantation
Creators: name: Matz, Mareen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: T-cell-mediated rejection
subject: Kidney Transplantation
subject: MicroRNA
subject: Next Generation Sequencing
subject: Biomarker
subject: antibody-mediated rejection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die Transplantation einer gesunden Spenderniere ist die etablierte Behandlungsmethode der Wahl bei terminaler Niereninsuffizienz. Trotz hervorragender Kurzzeit-Überlebensraten des Transplantats, die durch Weiter- und Neuentwicklungen immunsuppressiver Therapieschemata sowie eine gute Typisierungsqualität und Patientenversorgung erreicht werden konnten, gefährdet doch jede Rejektionsepisode den Transplantationserfolg. Neben der T-Lymphozyten-vermittelten Rejektion sowie der Interstitiellen Fibrose/Tubulären Atrophie ist besonders die durch Antikörper mediierte Rejektion als Hauptrisikofaktor für Transplantatschädigung und –Verlust zu nennen. Eine möglichst frühe spezifische, sensitive und wenig invasive Diagnose dieser Komplikationen nach einer Nierentransplantation wäre folglich von großem Interesse für die Klinik. Die Identifizierung kodierender RNAs und ihrer Translationsprodukte, aber auch nichtkodierender RNAs, die in Rejektionsmechanismen involviert und infolgedessen reguliert sind, könnte zur Entwicklung neuer Monitoringstrategien und Möglichkeiten zur Diagnostik beitragen. Basierend auf Genchip-Experimenten sowie Hochdurchsatzsequenzierungen konnten in Studien mit großen Kohorten von Patienten mit verschiedenen Pathologien nach Nierentransplantation Kandidatenmarker in Zellen des peripheren Blutes identifiziert und validiert werden, deren Expressionsregulierung hinweisend für Antikörper-vermittelte Rejektion, T-Lymphozyten-vermittelte Rejektion und Interstitielle Fibrose/Tubuläre Atrophie sein kann. Hierbei wurden sowohl kodierende RNAs als auch nicht-kodierende MicroRNAs analysiert. Weiterhin wurde die Expression der MicroRNA-Kandidaten in freier Form sowie die Translationsprodukte der mRNA-Kandidaten in Serum bzw. Plasma und auch im Urin untersucht. Der besondere Fokus lag dabei auf dem Vergleich von differierenden Komplikationen nach einer Nierentransplantation mit entsprechend voneinander abweichenden Therapieschemata, um eine spezifische und sensitive Diagnosestellung zu erlauben. Um die Möglichkeiten zur Translation der Ergebnisse in die Klinik zu bewerten, sind Folgestudien unter Einbindung mehrerer Transplantationszentren und damit einer hohen Patientenzahl zwingend notwendig. Wünschenswert sind weiterhin mechanistische Studien, die über die Identifizierung von Biomarkern für Komplikationen nach Nierentransplantation hinausgehen. Ein tieferes Verständnis der Pathologien von Antikörper-vermittelten Rejektion, T-Lymphozytenvermittelten Rejektion und Interstitieller Fibrose/Tubulärer Atrophie könnte die Weiterentwicklung von individualisierten Behandlungsmöglichkeiten der nierentransplantierten Patienten fördern.
title: Malformación Adenomatoidea Quística Pulmonar.
Creators: name: Ruiz Guerrero, Clara
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Thorax

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Presentar nuestra experiencia en este tipo de patología congénita y destacar las principales entidades que plantean el Diagnóstico...
Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker
Creators: name: Burock, Susen
name: Herrmann, Pia
name: Wendler, Ina
name: Niederstrasser, Markus
name: Wernecke, Klaus-Dieter
name: Stein, Ulrike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: METHODS: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient plasma. MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers. We conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients, either newly diagnosed with gastric cancer, newly diagnosed with metachronous metastasis of gastric cancer, as well as follow-up patients. Findings were controlled by using plasma samples from 54 tumor-free volunteers. Plasma was separated, RNA was isolated, and levels of MACC1 as well as S100A4 transcripts were determined by quantitative RT-PCR. RESULTS: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumor-free volunteers and gastric cancer patients (P < 0.001). Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage, compared to tumor-free volunteers: patients with tumors without metastasis (P = 0.005), with synchronous metastasis (P = 0.002), with metachronous metastasis (P = 0.005), and patients during follow-up (P = 0.021). Sensitivity was 0.68 (95%CI: 0.45-0.85) and specificity was 0.89 (95%CI: 0.77-0.95), respectively. Importantly, gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival when compared with patients demonstrating low MACC1 levels (P = 0.0015). Furthermore, gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated (P = 0.001). CONCLUSION: Levels of circulating MACC1 transcripts in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival in a prospective study.
title: La TC multicorte en la valoración del traumatismo esquelético de las extremidades. Una aproximación práctica.
Creators: name: Ríos Reboredo, Angel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Musculoskeletal bone
subject: CT
subject: Trauma

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar las aplicaciones de la TC multicorte (TCMC) en la valoración de las fracturas de extremidades. Mostrar los aspectos clave que influyen en el tratamiento de estas lesiones y que los radiólogos debemos de tener en cuenta en la elaboración...
Biosystematics of the Ionaspis-Hymenelia complex (lichenized Ascomycotina) in North America: A study at the generic level.
Creators: name: Lutzoni, François M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Botany.

description: The aim of the study was to circumscribe natural entities within the Ionaspis-Hymenelia complex and to assess the degree of similarity of these entities along with related genera, Eiglera and Aspicilia. A total of six species groups ("alba", epulotica, haematina, lacustris, melanocarpa, and odora) were recognized within the Ionaspis-Hymenelia complex; Eiglera and Aspicilia were maintained as distinct genera. For the most part, the cluster analysis of the electrophoretic data concurred with that of the anatomical-morphological study, except to suggest that the odora group was more closely affiliated with the "alba" and lacustris groups, and that the genus Eiglera and the epulotica group each were more closely affiliated with the melanocarpa and haematina groups. The specimens cited in the original description of the type species of Hymenelia (H. prevostii) were found to be associated with either one or the other photobiont. Three genera are recognized within the Ionaspis-Hymenelia complex. As newly circumscribed genera based on North American species, Hymenelia includes the haematina, melanocarpa and epulotica species groups, and Ionaspis includes only the odora species group. A new genus is recognized, "Hymeneliella", which includes the lacustris and "alba" species groups. (Abstract shortened by UMI.)
Dynix Horizon und IBM Digital Library - Vergleich und Abgrenzung der beiden Systeme
Creators: name: Hölting, Guido
name: Hänisch, Till
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Digital Library
subject: Digitale Bibliothek
subject: Horizon
subject: Elektronische Bibliothek
subject: IBM

description: Das Land Baden-Württemberg hat sich für ein landeseinheitliches Lokal- und Verbundsystem in seinen öffentlichen Bibliotheken entschieden, das auf der Basis modernster EDV-Technologie (Datenbank, Netzwerk, Betriebssysteme etc.) die Bibliotheken für die Herausforderungen der Informationsgesellschaft in angemessener Weise vorbereiten soll. Die Wahl ist dabei auf das Bibliothekssystem HORIZON der Firma Dynix gefallen. In Anbetracht einer Reihe ähnlich titulierter Produkte anderer Anbieter, die sich ebenfalls im Rahmen von Projekten um Fördermittel des Landes bewerben - insbesondere steht im folgenden die Digital Library der IBM exemplarisch im Vordergrund - ist eine begriffliche Abgrenzung und funktionale Analyse erforderlich. HORIZON ist danach ein integriertes Bibliothekssystem, das zur effizienteren Abwicklung der bibliothekarischen Arbeiten von den Möglichkeiten der modernen Informationstechnologie Gebrauch macht und daher zunächst auch nur einen den klassischen Arbeiten innerhalb einer Bibliothek entsprechenden Funktionsumfang aufweist (Katalogisierung, Erwerbung, Ausleihe, OPAC etc.). Es handelt sich also um ein System, das die Bestände lediglich erwirbt, erfaßt, nachweist und verwaltet. Die Digital Library der IBM repräsentiert dagegen den Typ einer elektronischen bzw. digitalen Bibliothek, deren Aufgabe es vornehmlich ist, Inhalte eines multimedialen Charakters (Text, Bild, Ton, Video etc.) zu speichern und zu distribuieren. Dazu gehört sicher auch ein Katalogsystem, das jedoch in den meisten verfügbaren Produkten dieser Kategorie nur einen minimalen Funktionsumfang aufweist und insbesondere durch das Fehlen von Modulen zur Bewältigung der nach wie vor erforderlichen klassischen Bibliotheksarbeit nur für die digitale Bibliothek selbst brauchbar ist. Die Zielsetzung ist eine andere. Im Idealfall könnten Systeme beiden Typs sich in einer modernen, zukunftsorientierten Bibliothek bzw. einem Verbund sinnvoll ergänzen und von ihren besonderen Leistungsfähigkeiten gegenseitig profitieren.
A study of a symbol-rate timing recovery algorithm for a digital ISDN U-transceiver.
Creators: name: Hage, Mirna.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Electronics and Electrical.

description: A symbol rate timing recovery scheme suitable for ISDN transmission on digital subscriber loops is investigated. Four timing estimates based on this scheme are studied for steady-state and convergence behavior. Theoretical analysis and simulation results are included. The effect of the various system parameters such as channel distortion, noise and dead-zone threshold is examined for the four timing estimates. Their performance on realistic loops in a practical U-transceiver using 2B1Q line code is characterized and compared. The performance will be evaluated principally by the receiver convergence, steady-state timing jitter and noise margin allowed before convergence is lost.
Supplementary document for Photonic realization of quantum resetting - 4614837.pdf
Creators: name: Xu, Feihu
name: Li, Zheng-Da
name: Yin, Xu-Fei
name: Wang, Zizhu
name: Liu, Li-Zheng
name: Zhang, Rui
name: Zhang, Yu-Zhe
name: Jiang, Xiao
name: Zhang, Jun
name: Li, Li
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: The details of experimental setup and more experimental results.
Immunoadsorption and plasma exchange in seropositive and seronegative immune-mediated neuropathies
Creators: name: Davies, Alexander J.
name: Fehmi, Janev
name: Senel, Makbule
name: Tumani, Hayrettin
name: Dorst, Johannes
name: Rinaldi, Simon
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Inflammatory neuropathy
subject: chronic inflammatory demyelinating polyneuropathy
subject: paranodal antibodies
subject: DDC 610 / Medicine & health
subject: Guillain-Barré syndrome
subject: Multiple sclerosis
subject: Plasmapheresis
subject: Plasma exchange (Therapeutics)
subject: Immunoadsorption
subject: Multiple Sklerose
subject: Plasmapherese
subject: Immunadsorption

description: The inflammatory neuropathies are disabling conditions with diverse immunological mechanisms. In some, a pathogenic role for immunoglobulin G (IgG)-class autoantibodies is increasingly appreciated, and immunoadsorption (IA) may therefore be a useful therapeutic option. We reviewed the use of and response to IA or plasma exchange (PLEx) in a cohort of 41 patients with nodal/paranodal antibodies identified from a total of 573 individuals with suspected inflammatory neuropathies during the course of routine diagnostic testing (PNAb cohort). 20 patients had been treated with PLEx and 4 with IA. Following a global but subjective evaluation by their treating clinicians, none of these patients were judged to have had a good response to either of these treatment modalities. Sequential serology of one PNAb+ case suggests prolonged suppression of antibody levels with frequent apheresis cycles or adjuvant therapies, may be required for effective treatment. We further retrospectively evaluated the serological status of 40 patients with either Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP), and a control group of 20 patients with clinically-isolated syndrome/multiple sclerosis (CIS/MS), who had all been treated with IgG-depleting IA (IA cohort). 32 of these patients (8/20 with CIDP, 13/20 with GBS, 11/20 with MS) were judged responsive to apheresis despite none of the serum samples from this cohort testing positive for IgG antibodies against glycolipids or nodal/paranodal cell-adhesion molecules. Although negative on antigen specific assays, three patients’ pre-treatment sera and eluates were reactive against different components of myelinating co-cultures. In summary, preliminary evidence suggests that GBS/CIDP patients without detectable IgG antibodies on routine diagnostic tests may nevertheless benefit from IA, and that an unbiased screening approach using myelinating co-cultures may assist in the detection of further autoantibodies which remain to be identified in such patients.
The effects of intranasal esketamine (84 mg) and oral mirtazapine (30 mg) on on-road driving performance: a double-blind, placebo-controlled study
Creators: name: van de Loo, Aurora J.A.E.
name: Bervoets, Adriana C.
name: Mooren, Loes
name: Bouwmeester, Noor H.
name: Garssen, Johan
name: Zuiker, Rob
name: van Amerongen, Guido
name: van Gerven, Joop
name: Singh, Jaskaran
name: der Ark, Peter Van
name: Fedgchin, Maggie
name: Morrison, Randall
name: Wajs, Ewa
name: Verster, Joris
Publisher: name: Swinburne
Year: 2024

description: Rationale: The purpose of this study is to evaluate the single dose effect of intranasal esketamine (84 mg) compared to placebo on on-road driving performance. Mirtazapine (oral, 30 mg) was used as a positive control, as this antidepressant drug is known to negatively affect driving performance. Methods: Twenty-six healthy volunteers aged 21 to 60 years were enrolled in this study. In the evening, 8 h after treatment administration, participants conducted the standardized 100-km on-road driving test. Primary outcome measure was the standard deviation of lateral position (SDLP), i.e., the weaving of the car. Mean lateral position, mean speed, and standard deviation of speed were secondary outcome measures. For SDLP, non-inferiority analyses were conducted, using +2.4 cm (relative to placebo) as a predefined non-inferiority margin for clinical relevant impairment. Results: Twenty-four participants completed the study. No significant SDLP difference was found between esketamine and placebo (p = 0.7638), whereas the SDLP after mirtazapine was significantly higher when compared to placebo (p = 0.0001). The upper limit of the two-sided 95% confidence interval (CI) of the mean difference between esketamine and placebo was +0.86 cm, i.e., < +2.4 cm, thus demonstrating that esketamine was non-inferior to placebo. Non-inferiority could not be concluded for mirtazapine (+3.15 cm SDLP relative to placebo). No significant differences in mean speed, standard deviation of speed, and mean lateral position were observed between the active treatments and placebo. Conclusions: No significant difference in driving performance was observed 8 h after administering intranasal esketamine (84 mg) or placebo. In contrast, oral mirtazapine (30 mg) significantly impaired on road driving performance.
Biomedical applications of DNA‐based hydrogels
Creators: name: Gačanin, Jasmina
name: Synatschke, Christopher V.
name: Weil, Tanja
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: biomedicine
subject: biosensors
subject: cell scaffolds
subject: DNA hydrogels
subject: drug delivery
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Biosensors
subject: Drug delivery systems
subject: Biomedizin
subject: Biosensor

description: Nucleic acids are gaining significant attention as versatile building blocks for the next generation of soft materials. Due to significant advances in the chemical synthesis and biotechnological production, DNA becomes more widely available enabling its usage as bulk material in various applications. This has prompted researchers to actively explore the unique features offered by DNA-containing materials like hydrogels. In this review article, recent developments in the field of hydrogels that feature DNA as a component either in the construction of the material or as functional unit within the construct and their biomedical applications are discussed in detail. First, different synthetic approaches for obtaining DNA hydrogels are summarized, which allows classification of DNA materials according to their structure. Then, new concepts, properties, and applications are highlighted such as DNA-based biosensor devices, drug delivery platforms, and cell scaffolds. With the 2018 Nobel Prize in Physiology or Medicine being awarded to cancer immunotherapy underscoring the importance of this therapy, DNA hydrogel systems designed to modulate the immune system are introduced. This review aims to give the reader a timely overview of the most important and recent developments in this emerging class of therapeutically useful materials of DNA-based hydrogels.
Supplementary document for Phonon counting thermometry of an ultracoherent membrane resonator near its motional ground state - 4618560.pdf
Creators: name: Galinskiy, Ivan
name: Parniak, Michal
name: Tsaturyan, Yeghishe
name: Polzik, Eugene
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental material
Model-based retrieval of phase-related quantities for two-port microwave devices
Creators: name: Fang, Wei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.

description: In this thesis a new method is proposed for the retrieval of phase-related quantities from magnitude-only measurements on two-port microwave systems. The method is applicable when a microwave system is manufactured in relatively large quantities. A reduced-order model is developed using the prototype of such a system. Such a reduced-order model will include a number of quantities or "coefficients" (other than frequency) whose value is determined using a full vector data set on the prototype. Establishing the form required for the reduce-order model acts as the additional constraints that are needed to provide a unique relationship between the transfer function magnitude and its phase. When later production models are tested using magnitude-only measurements, optimization is used (with the above-mentioned "coefficients" as the optimization variables, for which only small adjustments are needed from one device to another) to match the measured and modeled magnitude responses. The retrieved "coefficients" are then used to predict the phase response using the model. The use of the model-based retrieval technique is demonstrated through its application to three different types of device.
Supplementary document for Phonon counting thermometry of an ultracoherent membrane resonator near its motional ground state - 4618560.pdf
Creators: name: Galinskiy, Ivan
name: Parniak, Michal
name: Tsaturyan, Yeghishe
name: Polzik, Eugene
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemental material