cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An Informational Rationale for Political Parties
Creators: name: Ting, Michael M.
name: Snyder, James M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: This article studies a model of political parties as informative "brands" to voters. Voters across a large number of constituencies are assumed to be risk averse and incompletely informed about candidate ideal policies, and candidates are unable to commit to a declared policy platform. In this environment, parties can play a critical role by aggregating ideologically similar candidates and signaling their preferences to voters. This signaling is effective because party membership imposes costs, which screen out candidates whose preferences are not sufficiently close to the party's platform. We find that when party labels are very informative, the parties' platforms converge. When party labels are less informative, however, platforms diverge, because taking an extreme position allows a party to reduce the variance of its members' preferences. As parties become less able to impose costs on their members, or less able to screen out certain types of candidates, their platforms move further apart.
Scaled indium oxide transistors fabricated using atomic layer deposition
Creators: name: Si, Mengwei
name: Lin, Zehao
name: Chen, Zhizhong
name: Sun, Xing
name: Wang, Haiyan
name: Ye, Peide D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: In order to continue to improve integrated circuit performance and functionality, scaled transistors with short channel lengths and low thickness are needed. But the further scaling of silicon-based devices and the development of alternative semiconductor channel materials that are compatible with current fabrication processes is challenging. Here we report atomic-layer-deposited indium oxide transistors with channel lengths down to 8 nm, channel thicknesses down to 0.5 nm and equivalent dielectric oxide thickness down to 0.84 nm. Due to the scaled device dimensions and low contact resistance, the devices exhibit high on-state currents of 3.1 A/mm at a drain voltage of 0.5 V and a transconductance of 1.5 S/mm at a drain voltage 1 V. Our devices are a promising alternative channel material for scaled transistors with back-end-of-line processing compatibility.
description: 30 pages, 9 figures. Nat Electron (2022)
(3636) Isabella Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Comparing Competing Theories on the Causes of Mandate Perceptions
Creators: name: Peterson, David
name: Stimson, James
name: Grossback, Lawrence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The discussion of presidential mandates is as certain as a presidential election itself. Journalists inevitably discuss whether the president-elect has a popular mandate. Because they see elections as too complex to allow the public to send a unitary signal, political scientists are more skeptical of mandates. Mandates, however, have received new attention by scholars asking whether perceptions of mandate arise and lead representatives to act as if voters sent a policy directive. Two explanations have emerged to account for why elected officials might react to such perceptions. One focuses on the President’s strategic decision to declare a mandate, the second on how members of Congress read signals of changing preferences in the electorate from their own election results. We test these competing views to see which more accurately explains how members of Congress act in support of a perceived mandate. The results indicate that members respond more to messages about changing preferences than to the president’s mandate declaration.
Single Photon Level Study of Microwave Properties of Lithium Niobate at milli-Kelvin Temperatures
Creators: name: Goryachev, Maxim
name: Kostylev, Nikita
name: Tobar, Michael E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Properties of doped and natural impurities in Lithium Niobate single crystals are studied using the Whispering Gallery Mode method at low temperatures as a function of magnetic field. The study reveals considerable coupling of microwave photon modes to the Fe$^{3+}$ spin ensemble in iron-doped and non-doped crystals. The $S=5/2$ structure of the Fe$^{3+}$ impurities demonstrate Zero Field Splittings of $11.21$ and $20.96$ GHz, significant asymmetry of the Zeeman lines and additional lines with anomalous $\text{g}$-factors of $1.37$ and $3.95$. Also, interactions between different transitions of the Fe$^{3+}$ ion is observed. An additional ion impurity ensemble with a splitting of about $1.7$ GHz is shown to couple to the dominating Fe$^{3+}$ spins and the effect on $Q$-factors of microwave photon modes due to the Fe$^{3+}$ ion ensemble is also demonstrated. Measurements down to less than one photon level are made with a loss tangent of order $10^{-5}$ determined.
The Added Benefit of Bicycle Commuting on the Regular Amount of Physical Activity Performed
Creators: name: Garcia-Aymerich, Judith
name: de Nazelle, Audrey
name: Ambros, Albert
name: Cole-Hunter, Tom
name: Curto, Ariadna
name: Donaire-Gonzalez, David
name: Basagaña, Xavier
name: Jerrett, Michael
name: Nieuwenhuijsen, Mark
name: Mendez, Michelle
name: Rodriguez, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: INTRODUCTION: Physical inactivity is a leading cause of death and disability globally. Active transportation such as bicycling may increase physical activity levels. It is currently uncertain whether a shift from motorized transport modes to bicycle commuting leads to increased physical activity overall or substitutes other forms of physical activity. The study aims to disentangle whether bicycle commuting adds to or replaces other physical activities by comparing the physical activity performed by bicycle and motorized commuters.  METHODS: Physical activity, travel behavior, health status, sociodemographic, and built environment characteristics were assessed for 752 adults, between June 2011 and May 2012, in Barcelona, Spain. Statistical analyses, performed in 2013-2014, included linear, non-linear, and mixture models to estimate disparities and the dose-response relationship between physical activity duration and commute mode.  RESULTS: Regular bicycle commuters traveled by bicycle an average of 3.1 (SD=2.5) hours in the previous week. Bicycle commuting contributed positively to physical activity duration across participants (p<0.05). It amounted to 2.1 (95% CI=0.84, 3.55) hours/week extra of physical activity for bicycle commuters versus motorized commuters. Among bicycle travelers, there was a positive dose-response relationship between bicycle commuting and physical activity duration, with an average extra physical activity duration of 0.5 (95% CI=0.4, 0.6) hours/week for every additional 1 hour/week of bicycle commuting.  CONCLUSIONS: Bicycle commuting likely adds to overall physical activity. The extra physical activity performed by bicycle commuters is undertaken as moderate physical activity and follows a sigmoidal dose-response relationship with bicycle duration.
Beating non-linearities: improving the Baryon Acoustic Oscillations with the linear point
Creators: name: Anselmi, Stefano
name: Starkman, Glenn D.
name: Sheth, Ravi K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose a new way of looking at the Baryon Acoustic Oscillations in the Large Scale Structure clustering correlation function. We identify a scale s_LP that has two fundamental features: its position is insensitive to non-linear gravity, redshift space distortions, and scale-dependent bias at the 0.5% level; it is geometrical, i.e. independent of the power spectrum of the primordial density fluctuation parameters. These two properties together make s_LP, called the "linear point", an excellent cosmological standard ruler. The linear point is also appealing because it is easily identified irrespectively of how non-linearities distort the correlation function. Finally, the correlation function amplitude at s_LP is similarly insensitive to non-linear corrections to within a few percent. Hence, exploiting the particular Baryon features in the correlation function, we propose three new estimators for growth measurements. A preliminary analysis of s_LP in current data is encouraging.
description: 10 pages, 9 figures. Added discussion on the correlation function inflection point. This version matches the published MNRAS paper
(3637) Frances Marianne Goodall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ALGORITHMS, LEARNING, AND OPTIMIZATION
Creators: name: CESARI, TOMMASO RENATO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: This thesis covers some algorithmic aspects of online machine learning and optimization. In Chapter 1 we design algorithms with state-of-the-art regret guarantees for the problem dynamic pricing. In Chapter 2 we move on to an asynchronous online learning setting in which only some of the agents in the network are active at each time step. We show that when information is shared among neighbors, knowledge about the graph structure might have a significantly different impact on learning rates depending on how agents are activated. In Chapter 3 we investigate the online problem of multivariate non-concave maximization under weak assumptions on the regularity of the objective function. In Chapter 4 we introduce a new performance measure and design an efficient algorithm to learn optimal policies in repeated A/B testing.
When Reds are Redder and Blues are Bluer: Party Competition, Party Polarization, and the Changing Demand for Lobbying in the American States
Creators: name: Lowery, David
name: Shor, Boris
name: Cluverius, John
name: Gray, Virginia
name: Harden, Jeffrey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Interest system density influences internal dynamics within interest organizations, how they lobby, and policy conditions. But how do political conditions influence interest system density? How does politics create demand for interest representation? We examine these questions by assessing how legislative party competition and ideological distance between parties in state legislatures affect the number of lobby groups. After stating our theoretical expectations, we examine 1997 and 2007 data on legislative competition and party polarization to assess their influence on system density. We find mixed results: Whereas politics slightly influenced the structuring of nonprofit interest communities, they seem to have not affected the structuring of for-profit interest communities or interest communities as a whole.
title: Pollination Dynamics in Two Subalpine Flower Meadows
Creators: name: Beedlow, Peter Andrew
Publisher: name: Utah State University
Year: 1979

description: Plant-pollinator interactions were studied in two subalpine meadows to determine the role of pollination in structuring the herbaceous flower communities. The majority of the entomophilous plant species set significantly less seed when caged to prevent visitation than when exposed to flower visitors. Visitation rate was directly related to temperature and radiation. The number of animal species visiting flowers each week was directly related to the number of plant species in bloom. Most visitor species used ≤3 species of plants, while most plant species hosted ≤8 species of flower visitors. Floral niche breadth increased with increasing animal species diversity, but animal niche breadth was not related to flowering plant species diversity. The mean weekly visitation rate for each plant species was significantly related to floral relative density. Percent seed set was not related to visitation rate or flower density. Flowering period overlap and pollinator similarity varied for most species from one year to the next. There was no indication of competition for pollinators in either community. Supplementing the nectar of Geranium viscosissimum F.&M. resulted in a significant increase in the visitation rate and in the number of visiting species but did not affect either aspect of visitation to the other species in flower. The introduction of Penstemon cyananthus Hook. did not alter the visitation patterns of the other plant species.
Plant-pollinator interactions play an indirect role in the structuring of these floral communities. Cross pollination facilitates high genetic variability in subalpine plants, but does not appear to regulate the plant populations directly.
Environmental changes in the western Amazônia: morphological framework, geochemistry, palynology and radiocarbon dating data
Creators: name: Nogueira, Afonso
name: Horbe, Adriana
name: Behling, Hermann
name: Mapes, Russell
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The sediments from the Coari lake, a “terra firme” lake sculpted into Plio-Pleistocene deposits, and the Acará lake, a flooding-type lake developed on Quaternary sediments in the floodplain of the mid-Solimões river, in the western Amazônia, Brazil, were studied to investigate the environmental condition of their developing. This study includes mineral composition, geochemistry, Pb isotope, palinology, radiocarbon-age and morphological framework of the lakes obtained from SRTM satellite images. The geological and the environmental conditions in the two lakes are highly variable and suggest that their evolution reflect autogenic processes under humid rainforest condition. Although kaolinite, quartz, muscovite, illite, and smectite are the main minerals in both lakes, the geochemistry indicates distinct source, the Acará lake sediments have higher concentrations of Al2O3, Fe2O3, FeO, CaO, K2O, MgO, Na2O, P2O5, Ba, V, Cu, Ni, Zn, Pb, Sr, Li, Y and La and have more radiogenic Pb than the Coari lake sediments. The radiocarbon ages suggest that at 10160 yr BP the Coari lake started to be developed due to avulsion of the Solimões river, and the Acará lake was formed by the meander abandonment of Solimões river retaining its grass dominated shore at ca. 3710 yr BP.
The ALMA archive and its place in the astronomy of the future
Creators: name: Stoehr, Felix
name: Lacy, Mark
name: Leon, Stéphane
name: Muller, Erik
name: Manning, Alisdair
name: Moins, Christophe
name: Jenkins, Dustin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Atacama Large Millimeter/submillimeter Array (ALMA), an international partnership of Europe, North America and East Asia in cooperation with the Republic of Chile, is the largest astronomical project in existence. While ALMA's capabilities are ramping up, Early Science observations have started. The ALMA Archive is at the center of the operations of the telescope array and is designed to manage the 200 TB of data that will be taken each year, once the observatory is in full operations. We briefly describe design principles. The second part of this paper focuses on how astronomy is likely to evolve as the amount and complexity of data taken grows. We argue that in the future observatories will compete for astronomers to work with their data, that observatories will have to reorient themselves to from providing good data only to providing an excellent end-to-end user-experience with all its implications, that science-grade data-reduction pipelines will become an integral part of the design of a new observatory or instrument and that all this evolution will have a deep impact on how astronomers will do science. We show how ALMA's design principles are in line with this paradigm.
description: 9 pages, 5 figures, published in the Proceedings of SPIE, vol. 9149, 914902 (2014)
LO SCIOGLIMENTO DEI CONSIGLI COMUNALI PER INFILTRAZIONI E CONDIZIONAMENTO DI TIPO MAFIOSO. PROBLEMI E PROSPETTIVE.
Creators: name: OCCHIUZZI, FILOMENA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: The topic of this thesis is the dissolution of Italian Municipal Councils due to organized crime infiltration. It was introduced into Italian legislation in 1991 as a specific legal remedy, following serious episodes of subjugation of local councils to the pressure and interests of mafia organizations. The first section of the thesis will analyse the topic from a developmental perspective, placing it in its historical legal context. The law is currently laid down in Art. 143 d.lgs. n. 267/2000 ?Consolidated Law on the organization of local authorities? and was established to preserve fundamental values and constitutional principles such as public order and security, legality, good performance and impartiality of public administration. The procedure leads to the dissolution of the Municipal Council and has a profound effect on local democracy. Since its introduction in 1991, its interpretation and application has been controversial. The thesis will therefore analyze the debate about its constitutional legitimacy and legal framework by exploring juridical opinions and the constitutional and administrative caselaw on the subject. It also examines the typical causes leading up to the disbanding of Municipal Councils. The law is also aimed at administrative prevention, operating within the supervisory system for local authorities in order to preserve best practices in public administration. The thesis will explore the legal framework of the administrative prevention of corruption from the perspective of anti-mafia strategy, given that methods of corruption are frequently used by the mafia as a means of infiltrating local councils. The next section deals with the post-dissolution phase, particularly the management of the Special Commissions that replace local councils: there are many impediments to the successful and lasting impact of their work, such as the inadequate legal instruments at their disposal, as well as the complexity of the dissolved administrations. A crucial aspect of the thesis involves the way that organized crime has moved its operations outside traditional territories. In recent years, this has led to a radical increase in the number of local authorities being disbanded in the central and northern areas of Italy. The thesis will analyse these changes from a diachronic and territorial perspective. Overall, the thesis argues that the current debate on the legislative proposals about the revision of Art. 143 suggests that the law is still adequate but a more successful and definitive solution to the problem of mafia infiltration in local administration can only involve a much more profound cultural evolution of Italian society.
Direct Measurement of Time-Frequency Analogues of Sub-Planck Structures
Creators: name: Praxmeyer, Ludmila
name: Chen, Chih-Cheng
name: Yang, Popo
name: Yang, Shang-Da
name: Lee, Ray-Kuang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Exploiting the correspondence between Wigner distribution function and a frequency-resolved optical gating (FROG) measurement, we experimentally demonstrate existence of the chessboard-like interference patterns with a time-bandwidth product smaller than that of a transform-limited pulse in the phase space representation of compass states. Using superpositions of four electric pulses as realization of compass states, we have shown via direct measurements that displacements leading to orthogonal states can be smaller than limits set by uncertainty relations. In the experiment we observe an exactly chronocyclic correspondence to the sub-Planck structure in the interference pattern appearing for superposition of two Schödinger-cat-like states in a position-momentum phase space.
description: 5 pages, 5 figures
Optimal design of hyperelastic structures using topology optimization
Creators: name: Homberger, Stefanie
Publisher: name: Zenodo
Year: 2023
Subjects: Elastostatics
Hyperelasticity
Topology optimization
Optimal control
Nonlinear boundary value problem

description: We deal with an optimal control problem governed by a nonlinear boundary value problem in elastostatics. The corresponding semilinear form depends on a control as well as a state variable. In the elastostatic setting the control variable, also called design variable, describes the material distribution of the structure and the state variable its displacement. The task of the optimal design problem is to find an optimal material distribution of the structure in the sense of minimizing its mechanical compliance while the equilibrium and other constraints on the design variable are satisfied. The nonlinear boundary value problem stated in its weak form will be linearized by Newton's method and discretized with a finite element based Galerkin scheme. Most problems in topology design have non-unique solutions. Therefore, we solve a regularized optimal design problem. The sensitvity analysis is performed with the adjoint method. Some filtering techniques and optimality criteria will be presented and finally numerical simulations are performed.
description: Download: https://www.amazon.de/dp/B0CGPP16LV
(3638) Enid Frances Goodall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
IQTISOD VA MA'NAVIYAT UYG'UNLIGI
Creators: name: Tulayeva, Dilafruz
Publisher: name: Zenodo
Year: 2024

description: Insonning ishlab chiqarish faoliyati ham nafaqat iqtisodiy, shuningdek o’zining ma’naviy jihatlariga ega. Iqtisodiyot bilan ma’naviyatga katta ahamiyat bergan jamiyat o’zining yirik ijtimoiy ziddiyatlarsiz va qarama-qarshiliklarsiz barqaror taraqqiy etishi uchun zamin yaratadi. Gap iqtisodiyotning moddiy boyliklar, ma’naviyatning esa aqliy va hissiy boyliklar yaratishi, jamiyatga bu boyliklarning har ikkalasi ham kerakligi ustida ketayotgani yo’q, balki gap ma’naviyat va iqtisodiyotning o’zaro ta’siri ustida ketayapti.
title: Statistical Challenges and Methods for Missing and Imbalanced Data
Creators: name: Adjei, Rose
Publisher: name: Utah State University
Year: 2022

description: Missing data remains a prevalent issue in every area of research. The impact of missing data, if not carefully handled, can be detrimental to any statistical analysis. Some statistical challenges associated with missing data include, loss of information, reduced statistical power and non-generalizability of findings in a study. It is therefore crucial that researchers pay close and particular attention when dealing with missing data. This multi-paper dissertation provides insight into missing data across different fields of study and addresses some of the above mentioned challenges of missing data through simulation studies and application to real datasets. The first paper of this dissertation addresses the dropout phenomenon in single-cell RNA (scRNA) sequencing through a comparative analyses of some existing scRNA sequencing techniques. The second paper of this work focuses on using simulation studies to assess whether it is appropriate to address the issue of non-detects in data using a traditional substitution approach, imputation, or a non-imputation based approach. The final paper of this dissertation presents an efficient strategy to address the issue of imbalance in data at any degree (whether moderate or highly imbalanced) by combining random undersampling with different weighting strategies. We conclude generally, based on findings from this dissertation that, missingness is not always lack of information but interestingness that needs to investigated.
ROLE OF ALOG FAMILY GENES IN INFLORESCENCE PATTERNING IN ORYZA SATIVA AND ARABIDOPSIS THALIANA
Creators: name: FRANCHINI, EMANUELA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Inflorescence architecture is a key agronomical trait that determines fruit and seed yield. Understanding the genetic basis of inflorescence architecture will not only contribute to elucidate crop evolution/domestication mechanisms but also improve crop grain yield. Flowering plants develop different types of inflorescences, such as racemes in Arabidopsis and panicles in rice. The architecture is established during the early stages of reproductive development and it is determined by the activity of different meristem types and by the timing of the transition between indeterminate meristems to determinate ones. Inflorescence development is finely regulated by a genetic network that includes meristem identity genes and genes that regulate their expression; many genes are already known but others have still to be characterized to provide insight into how this complex process is controlled. Transcriptomic analysis performed in rice and in Arabidopsis through laser microdissection of different meristematic tissues highlighted differentially expressed genes belonging to the ALOG family suggesting their role in inflorescence patterning. We focus on G1L1, G1L2, and G1L5 of rice and on LSH1, LSH3, and LSH4 of Arabidopsis. G1L5 is already known to be a major regulator of inflorescence architecture, whereas LSH3 and LSH4 seem to have a role in meristem maintenance and organogenesis. Their expression profiles were analyzed by qRT-PCR and RNA in situ hybridization experiments using meristematic tissues from both species. We are also generating single and double/triple K.O mutants in different combinations by CRISPR-Cas9 genome editing technology to have a better understanding of their role in inflorescence patterning. The data so far obtained demonstrate the role of G1L1 and G1L2 in inflorescence branching and spikelet number determination and we also propose a role for G1L2 in root development. Furthermore, LSH1 seems to be involved in meristem maintenance and organ differentiation, and LSH3 in stem elongation. We propose the hypothesis that LSH1, LSH3, and LSH4 play a redundant function in inflorescence development.
REPETITIVE MEMBRANE POTENTIAL OSCILLATIONS ENHANCE METFORMIN�S ANTIPROLIFERATIVE EFFECT ON GLIOBLASTOMA CANCER STEM CELLS
Creators: name: VERDUCI, IVAN
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Glioblastoma (GB) is the most common brain tumor with an extremely poor prognosis. Although the current standard of care is a combination of surgery, chemo, and radiotherapy, their effectiveness remains extremely poor in terms of patients? survival. Recent publications highlight the presence of a functional subset of cells that may be responsible for tumor recurrence and resistance to conventional therapies. This subset is known as glioblastoma stem cells (GSCs). New strategies selectively targeting GSCs and/or their microenvironmental niche should be designed. The chloride intracellular channel 1 (CLIC1) represents a fruitful research topic to achieve this purpose since its functional activity was reported to be related to glioblastoma aggressiveness. CLIC1 is a peculiar protein that coexist in two isoforms. In normal condition it?s mostly cytoplasmic, while in response to persistent stress translocates to the plasma membrane (tmCLIC1) determining a chloride conductance. tmCLIC1 was found to be chronically expressed in GSCs sustaining their abnormal in vitro proliferation rate. Given this, tmCLIC1 could be considered a promising pharmacological target to counteract glioblastoma progression. Our laboratory has recently found tmCLIC1 protein as an extracellular target of the antidiabetic drug metformin. Despite it is well known the antineoplastic effect of metformin, the mechanism of action remains unclear. It was proposed that the binding between metformin and tmCLIC1 occurs at the level of Arg29 only when the channel is in the open state. However, metformin impairs GSCs proliferation at a millimolar range, a concentration unattainable in the brain upon metformin oral administration. The purpose is to decrease metformin?s working concentration, enhancing its action on tmCLIC1. tmCLIC1 is a voltage dependent channel and its open probability increases under depolarization. We propose to enhance CLIC1-metformin interaction using repetitive membrane potential oscillations provided by field potential, optogenetics and electromagnetic field stimulations. In this work, we confirm that metformin inhibits CLIC1 channel by binding to the R29 amino acid, which is localized inside the pore region. We show that by applying stimulation to GSCs the operative metformin concentration is reduced up to 10-fold. In addition, we demonstrate that the phenomenon is specifically confined to metformin. The combination of metformin treatment with repetitive membrane depolarizations produce an average 30% decrease of GB progression compared to metformin itself in vitro as well as in vivo. Taken together, we provide insights of a new possible therapeutic approach to face glioblastoma progression by specifically targeting GSCs.
(3633) Nora Harrison
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Simultaneous cooling of coupled mechanical oscillators using whispering gallery mode resonances
Creators: name: Li, Ying Lia
name: Millen, James
name: Barker, P. F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate simultaneous center-of-mass cooling of two coupled oscillators, consisting of a microsphere-cantilever and a tapered optical fiber. Excitation of a whispering gallery mode (WGM) of the microsphere, via the evanescent field of the taper, provides a transduction signal that continuously monitors the relative motion between these two microgram objects with a sensitivity of 3 pm. The cavity enhanced optical dipole force is used to provide feedback damping on the motion of the micron-diameter taper, whereas a piezo stack is used to damp the motion of the much larger (up to $180\,μ$m in diameter), heavier (up to $1.5\times 10^{-7}\,$kg) and stiffer microsphere-cantilever. In each feedback scheme multiple mechanical modes of each oscillator can be cooled, and mode temperatures below 10 K are reached for the dominant mode, consistent with limits determined by the measurement noise of our system. This represents stabilization on the picometer level and is the first demonstration of using WGM resonances to cool the mechanical modes of both the WGM resonator and its coupling waveguide.
description: 10 pages, 8 figures
(3630) Anne Garnett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Error modeling and confidence interval estimation for inductively coupled plasma calibration curves
Creators: name: Spiegelman, Clifford
name: Carroll, Raymond
name: Watters, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: A simple linear calibration function can be used over a wide concentration range for the Inductively Coupled Plasma (ICP) spectrometer due to its linear response. The random errors over wide concentration  ranges are not constant, and constant variance regression should not be used to estimate the calibration function. Weighted regression techniques are appropriate if the proper weights can be obtained. Use of the calibratio curve to estimate the concetration of one or more unknown samples is straightforward, but confidence interval estimatation for multiple use of the calibration curve is less obvious. We describe a method for modeling the error along the ICP calibration curve and using the estimated parameters from the fitted model to calculate weights for the calibration curve fit. Multiple and single-use confidence interval estimates are obtained and results along the calibration curve are compared.
Multiplexing strategy for simultaneous detection of redox-, phospho- and total proteome – understanding TOR regulating pathways in Chlamydomonas reinhardtii
Creators: name: Alvarez, Sophie
name: Rodrigues, Silas
name: Gau, Brian
name: Werth, Emily
name: Cahoon, Edgar
name: Slade, William
name: Hicks, Leslie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: New methods for studying the complexity of multiple PTMs in functional proteomics are required to
understand cell signaling processes. In this study, a multiplexing 2DE-based approach is introduced for
parallel analysis of the redox-, phospho-, and total-proteome. This triplexing approach uses spectrally
distinct fluorophores, is not matrix-specific and requires relatively low sample amounts with applicability
to any cell/tissue type. This methodology was applied for the study of Target of Rapamycin (TOR)
regulating pathways in Chlamydomonas reinhardtii. With emerging research demonstrating a complex
yet unclear relationship between TOR kinase, autophagy, and lipid metabolism, rapamycin treatment was
used to induce TOR inhibition in C. reinhardtii and redox-, phospho- and total proteome changes were
assessed using the triplexing approach. We identified a total of 68 spot abundance changes in response
to TOR inhibition which provide a basis for understanding this highly conserved, master regulator in algae.
(3632) Isabel Dutton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An “inescapable obligation” : the treatment of well decommissioning liability in recent oil and gas bankruptcies
Creators: name: Cook, Kristin Alexandra
Publisher: name: The University of Texas at Austin
Year: 2019
Subjects: Bankruptcy
Petroleum
Oil and gas
Decommissioning
Plugging and abandonment
Insolvency
Orphan well

description: Oil prices fell by fifty percent during the latter half of 2014, tumbling from a high of $105 per barrel in June to a mere $53 per barrel by year’s end. As a result of sustained depressed commodities prices, more than 350 North American oil and gas operators and service companies filed for bankruptcy between January 2015 and September 2019, representing more than $162 billion of debt. Despite the existence of federal and state statutes ensuring that operators decommission wells at the end of economic life, these environmental laws frequently lose efficacy in bankruptcy proceedings. This unresolved conflict, among other contributing factors, has led to the existence of tens of thousands of “orphaned wells” in the United States. This thesis paper examines the bankruptcies of American oil and gas operators after the precipitous decline in oil prices to determine whether operators successfully discharged decommissioning liability during bankruptcy. A survey of 2015 bankruptcies shows that 33% of oil and gas operating companies abandoned properties with unmet decommissioning liability and created 285 new orphan wells in eight states. This paper also estimates the cost to plug and abandon wells orphaned from bankruptcies between 2015 and 2019 at more than $200 million. The paper concludes with a discussion of the advantages and disadvantages of several possible solutions to the orphan well problem.
Combinatorics of Rational Functions and Poincar- Birchoff-Witt Expansions of the Canonical U $({\frak n}\_)$ -Valued Differential Form
Creators: name: Stevens, L.
name: Varchenko, A.
name: Rimanyi, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Abstract. We study the canonical U Formula Not Shown -valued differential form, whose projections to different Kac-Moody algebras are key ingredients of the hypergeometric integral solutions of KZ-type differential equations and Bethe ansatz constructions. We explicitly determine the coefficients of the projections in the simple Lie algebras Ar, Br, Cr, Dr in a conveniently chosen Poincaré- Birchoff-Witt basis.
Additional file 1 of Comparing two methods for deriving dietary patterns associated with risk of metabolic syndrome among middle-aged and elderly Taiwanese adults with impaired kidney function
Creators: name: Kurniawan, Adi Lukas
name: Chien-Yeh Hsu
name: Hsiu-An Lee
name: Hsiao-Hsien Rau
name: Rathi Paramastri
name: Syauqy, Ahmad
name: Chao, Jane C.-J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1: Table S1. Food groups used in the dietary pattern analysis.
All-Optical Depletion of Dark Excitons from a Semiconductor Quantum Dot
Creators: name: Schmidgall, E. R.
name: Schwartz, I.
name: Cogan, D.
name: Gantz, L.
name: Heindel, T.
name: Reitzenstein, S.
name: Gershoni, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Semiconductor quantum dots are considered to be the leading venue for fabricating on-demand sources of single photons. However, the generation of long-lived dark excitons imposes significant limits on the efficiency of these sources. We demonstrate a technique that optically pumps the dark exciton population and converts it to a bright exciton population, using intermediate excited biexciton states. We show experimentally that our method considerably reduces the DE population while doubling the triggered bright exciton emission, approaching thereby near-unit fidelity of quantum dot depletion.
description: 5 pages, 3 figures
CHARACTERIZATION OF THE LIPOPOLYSACCHARIDE TRANSPORT MACHINERY USING AN ESCHERICHIA COLI/PSEUDOMONAS AERUGINOSA HYBRID SYSTEMAND ESCHERICHIA COLI LPTC MUTANTS.
Creators: name: BENEDET, MATTIA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Characterization of the lipopolysaccharide transport machinery using an Escherichia coli/Pseudomonas aeruginosa hybrid system and Escherichia coli lptC mutants The lipopolysaccharide (LPS) transport (Lpt) is an essential process for the biogenesis of the outer membrane (OM) in Gram negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. OM, the first bacterial defense against harsh environment and antimicrobial compounds, is composed by an inner leaflet of phospholipids, an outer leaflet of LPS, and outer membrane proteins. Lpt system, originally identified in E. coli, is a protein machine responsible for LPS delivery from the inner membrane, where it is synthesized, to the outer membrane. It is composed of seven proteins, LptA through LptG, which form a complex spanning the IM and OM. LptBCFG are located at the IM, LptA in the periplasm, and LptDE at the OM. The lpt genes are evolutionarily conserved and appear to play an essential role in most Proteobacteria. To understand how LPS is delivered to the OM crossing the hydrophilic periplasmic space, we focused on the role of the periplasmic components LptC and LptA by two main approaches: i) comparison between E. coli and P. aeruginosa Lpt systems to search for conserved features shared by the Lpt machines of different Gram negative species. By plasmid shuffling technique we showed that P. aeruginosa lptCAB genes can complement E. coli ?lptCAB mutants, thus indicating that the Pseudomonas proteins can interact with both the other proteins of the Lpt machine and the LPS of E. coli. Although E. coli and P. aeruginosa LptC and LptA proteins exhibit limited sequence identity and similarity, their 3D conformation is conserved. This suggests that LptA and LptC overall structure rather than their amino acid sequence may play a major role in Lpt assembly and LPS recognition and transport; ii) analysis of E. coli lptC mutants in order to elucidate the role of LptC in the system. E. coli appears to tolerate several mutations in lptC, including deletion of the trans membrane domain; moreover the lethality of the lptC C-terminal region deletion can be suppressed by an appropriate expression of lptB. We thus tested whether E. coli could tolerate the lack of LptC, which was thought to be essential. By plasmid shuffling we obtained viable mutants missing lptC. Genome sequencing of such mutants revealed single amino acid substitutions at the R212 residue of the IM component LptF (lptFSupmutants); in complementation tests, lptFSup mutants suppress lethality of LptC conditional expression mutants. These data show that a specific mutation in LptF can compensate the lack of LptC and suggest that LptC may serve as a chaperon of the Lpt machine assembly and/or activity rather than an essential structural component.
title: Numerical Modeling and Simulating Thermal Performance of Printed Circuit Boards
Creators: name: Ziegenfelder, Paul R.
Publisher: name: Utah State University
Year: 2022

description: This research investigates how heat transfer theory can be applied to evaluate the thermal performance of printed circuit board (PCB) designs. A model was developed for correlating theory to the physical parameters relating to the construction of the PCB and a computer application was developed to perform the thermal analysis. The application allows the importation of common PCB design files for a straightforward and quick analysis of a PCB design’s thermal performance. The application is open-source to allows for further development and free access from the public.
Extended Conformal Symmetry in $d\neq 4$: Conformal Symmetry of Abelian Gauge Theory in the Physical Sector
Creators: name: Chiu, Kelly Yu-Ju
name: Brodsky, Stanley J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Abelian gauge theory in $d\neq 4$ spacetime dimensions is an example of a scale invariant theory which does not possess conformal symmetry -- the special conformal transformation(SCT) explicitly breaks the gauge invariance of the theory. In this work, we construct a non-local gauge-invariant extension of the SCT, which is compatible with the BRST formalism and defines a new symmetry of the physical Hilbert space of the Maxwell theory for any dimension $d\geqslant 3$. We prove the invariance of the Maxwell theory in $d\geqslant 3$ by explicitly showing that the gauge-invariant two-point correlation functions, the action, and the classical equation of motion are unchanged under such a transformation.
description: 23 pages
Additional file 1 of Out-of-hours workload among Norwegian general practitioners – an observational study
Creators: name: Rebnord, Ingrid Keilegavlen
name: Morken, Tone
name: Maartmann-Moe, Kjell
name: Hunskaar, Steinar
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Qualtrics Survey