cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ballognatha typica Caporiacco 1935
Creators: name: Prószyński, Jerzy
name: Lissner, Jørgen
name: Schäfer, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Ballognatha
Ballognatha typica

description: Ballognatha typica Caporiacco, 1935
 (as well as gen. Ballognatha Caporiacco, 1935 and group Ballognatheae (= Ballognathinae)) Figures 22-23
 Ballognatha typica Caporiacco, 1935: 215, pl. 6, f. 1 (Dj).
 Material studied. Ballognatha typica Caporiacco, 1935 - type specimen, coll. Museo Civico di Storia Naturale, Milano, Italy.
 Comments: Described on single immature specimen, in poor state of preservation, devoid of any significant diagnostic character. Original classification wrong because the only tangible structure - cheliceral dentition (Fig. 20 A) is rather "fissidentati" than "pluridentati" type, besides taxonomic significance of bicusp cheliceral tooth lost diagnostic value originally assigned to it by Simon (1901 -1903). The original description (see below, Fig. 31) does not contain any clue to eventual placement of the genus, and suggested therein partial similarities with genera Ballus, Euophrys, Pseudicius, Sobasina and Thiodina cannot be taken seriously. Quality of many other diagnostic drawings by di Caporiacco (Figs 17G 1, I1, N, O, Q) do not increase confidence in his identifications.
 After study of the type specimen I am positive that Ballognatha typica Caporiacco, 1935 is a nomen dubium. Since genus Ballognatha Caporiacco, 1935 was described as monotypic and the group Ballognatheae (= Ballognathine) Caporiacco, 1935 contained single genus anchored on species being nomen dubium, all these names should be considered nomina dubia.
 Therefore:
 Ballognatha typica Caporiacco, 1935 - nomen dubium,
 Ballognatha Caporiacco, 1935 - nomen dubium,
Ballognatheae (= Ballognathine) Caporiacco, 1935 - nomen dubium.
 SOURCES: A - Prószyński, unpublished, B - Caporiacco (1935) Memorie della Società Entomologica Italiana, 13: 214- 215, pl. 6, f. 1.
description: Published as part of Prószyński, Jerzy, Lissner, Jørgen & Schäfer, Michael, 2018, Taxonomic survey of the genera Euophrys, Pseudeuophrys and Talavera, with description of Euochin gen. n. (Araneae: Salticidae) and with proposals of a new research protocol *, pp. 26-74 in Ecologica Montenegrina 18 on page 70, DOI: 10.37828/em.2018.18.4, http://zenodo.org/record/13360279
Foil-based atom chip for Bose-Einstein condensates
Creators: name: Vale, Christopher
name: Upcroft, B.
name: Davis, M. J.
name: Heckenberg, N. R.
name: Rubinsztein-Dunlop, H.
Publisher: name: Swinburne
Year: 2024

description: We describe a novel method of fabricating atom chips that are well suited to the production and manipulation of atomic Bose-Einstein condensates. Our chip was created using a silver foil and simple micro-cutting techniques without the need for photolithography. It can sustain larger currents than conventional chips, and is compatible with the patterning of complex trapping potentials. A near pure Bose-Einstein condensate of 4 × 10 (487) Rb atoms has been created in a magnetic microtrap formed by currents through wires on the chip. We have observed the fragmentation of atom clouds in close proximity to the silver conductors. The fragmentation has different characteristic features to those seen with copper conductors.
Scène et philosophie : Théorie et pratique de la lecture philosophique pour un libre accès à la pensée
Creators: name: Molina, Vanessa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Théories de la lecture
Philosophie
Pensée
Scène
Sensation
Métaphore
Émancipation intellectuelle

description: Quel rapport y-a-t-il entre lire et penser? En empruntant à l'Éthique de Spinoza et au Plaisir du texte de Roland Barthes, nous postulons que pour penser, le lecteur a besoin d'être affecté par ce qu'il lit. En empruntant aux principes d'émancipation intellectuelle de Joseph Jacotot, nous considérons que tout le monde peut penser à la lecture du texte philosophique quand il est touché par celui-ci, à contre-courant d'un imaginaire hiérarchique très ancien et toujours ambiant. À partir de là, qu'est-ce qui fait que le lecteur pense par ses propres moyens, qu'il s'interroge à la lumière de ce qu’il a lu? Diverses théories de la lecture (Iser, Jauss, Eco, Picard, Thérien) ont intégré à leurs propos l'affection du lecteur, y voyant un élément important de la composition du sens. Cependant, ces théories tendent à associer la constitution du sens à l'harmonisation des tensions ressenties. Mais alors, si un retour au calme se produit en rendant le texte « sensé », c’est-à-dire cohérent, comment faire pour continuer à penser, avec ce que la lecture nous a fait ressentir? Notre apport repose sur une étude thématique montrant le lien intrinsèque entre les sensations et le phénomène scénique, ainsi que le rôle moteur de la scène dans les théories de la connaissance développées en Occident (chez Platon, Kant, Wittgenstein, Nietzsche). La scène permet ainsi de concevoir la pensée du lecteur au-delà de la composition du sens. En faisant comme si le texte philosophique qu’il lit était une scène – ce qui relève de la métaphore –, le lecteur élabore une cohérence d'ensemble. L’objectif de notre méthode est que, une fois la lecture achevée, sur la scène développée par le lecteur se déploient des sensations en tension. Ces tensions irrésolues donnent à penser, poussent à réfléchir, stimulent la capacité réflexive de chacun. L'approche élaborée est mise en pratique à la lecture du Banquet de Platon, du Maître ignorant de Rancière, de l’Ecce homo de Nietzsche et du Discours de la méthode de Descartes. Les « scènes de pensée » que nous construisons laissent des tensions insupportables. Elles donnent la matière et l'élan d'un questionnement sans réponse immédiate.
Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations
Creators: name: Gates, Allison
name: Pillay, Jennifer
name: Reynolds, Donna
name: Stirling, Rob
name: Traversy, Gregory
name: Korownyk, Christina
name: Moore, Ainsley
name: Thériault, Guylène
name: Thombs, Brett D
name: Little, Julian
name: Popadiuk, Catherine
name: Van Niekerk, Dirk
name: Keto-Lambert, Diana
name: Vandermeer, Ben
name: Hartling, Lisa
Publisher: name: BioMed Central
Year: 2021

description: Purpose: To inform recommendations by the Canadian Task Force on Preventive Health Care on screening in primary care for the prevention and early detection of cervical cancer by systematically reviewing evidence of (a) effectiveness; (b) test accuracy; (c) individuals’ values and preferences; and (d) strategies aimed at improving screening rates. Methods: De novo reviews will be conducted to evaluate effectiveness and to assess values and preferences. For test accuracy and strategies to improve screening rates, we will integrate studies from existing systematic reviews with search updates to the present. Two Cochrane reviews will provide evidence of adverse pregnancy outcomes from the conservative management of cervical intraepithelial neoplasia. We will search Medline, Embase, and Cochrane Central (except for individuals’ values and preferences, where Medline, Scopus, and EconLit will be searched) via peer-reviewed search strategies and the reference lists of included studies and reviews. We will search ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform for ongoing trials. Two reviewers will screen potentially eligible studies and agree on those to include. Data will be extracted by one reviewer with verification by another. Two reviewers will independently assess risk of bias and reach consensus. Where possible and suitable, we will pool studies via meta-analysis. We will compare accuracy data per outcome and per comparison using the Rutter and Gatsonis hierarchical summary receiver operating characteristic model and report relative sensitivities and specificities. Findings on values and preferences will be synthesized using a narrative synthesis approach and thematic analysis, depending on study designs. Two reviewers will appraise the certainty of evidence for all outcomes using GRADE (Grading of Recommendations Assessment, Development and Evaluation) and come to consensus. Discussion: The publication of guidance on screening in primary care for the prevention and early detection of cervical cancer by the Task Force in 2013 focused on cytology. Since 2013, new studies using human papillomavirus tests for cervical screening have been published that will improve our understanding of screening in primary care settings. This review will inform updated recommendations based on currently available studies and address key evidence gaps noted in our previous review.
MicroRNA-200b Signature in the Prevention of Skin Cancer Stem Cells by Polyphenol-Enriched Blueberry Preparation (PEBP)
Creators: name: Alsadi, Nawal
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Polyphenols, Skin cancer stem cells, Tumor, Metastasis, miR-200b, ZEB1

description: The incidence of melanoma and non‐melanoma skin cancer is continuing to increase worldwide. Melanoma is the sixth most common cancer in the United States, making skin cancer a significant public health issue. Photo chemoprevention with natural products is an effective strategy for the control of cutaneous neoplastic. Polyphenols from fruits have been shown to protect the skin from the adverse effects of solar UVR, cancer, and the growth of cancer stem cells. In particular, blueberries are known for their high concentration of phenolic compounds that have the high antioxidant capacity, and their effectiveness in reducing UV damage and, therefore, skin cancer. In Matar's lab, we have shown that Polyphenol-Enriched Blueberry Preparation (PEBP), derived from biotransformation of blueberry juice through fermentation, is effective for targeting skin cancer stem cell proliferation in different skin cancer cell lines. We predicted that PEBP affects melanoma skin cancer stem cells (MCSCs) epigenetically by targeting miRNA pathways. We observed the effects of PEBP on sphere growth and cell motility in vitro. We performed RT2-qPCR analyses to determine PEBP influence on miRNA in B16F10 spheres. We transfected B16F10 cells with miR-200b and performed western blotting analyses. Our results demonstrated that PEBP reduced sphere growth and cell migration, and up regulated miR-200b expression in different biological settings. Inhibition of miR-200b increased Zinc Finger E-Box Binding Homeobox 1 (ZEB1) expression. Consequently, PEBP may influence MCSCs through miRNA pathways. Elucidating the mechanisms by which PEBP modulates CSCs biological behavior by controlling miRNAs will enhance our understanding of the molecular mechanisms in skin cancer chemoprevention and might result in their use as natural photo-protectants in skin cancer.
Energy Efficient Secure Key Management Schemes for WSNs and IoT
Creators: name: Wen, Wen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Chinese Remainder Theorem
Secret Sharing
Secure
Energy Efficiency
Wireless Sensor Network
Internet of Things
Host Identity Protocol
Key Management
Key Exchange
Cryptography

description: Secret sharing is critical to most applications making use of security and remains one of the most challenging research areas in modern cryptography. In this thesis, we propose a novel efficient multi-secret sharing scheme based on the Chinese remainder theorem (CRT) with two verification methods, while the previous works are mostly based on the Lagrange polynomial. Key management schemes play an important role in communication security in Wireless Sensor Networks (WSNs). While the previous works mainly targeting on two different types of WSNs: distributed and hieratical, in this thesis, we propose our flexible WSN key management scheme, which is based on (n,t,n) multi-secret sharing technique, to provide a key management solution for heterogeneous architecture. The powerful key managers are responsible for most of the communicational and computational workload. They can provide Peer-to-Peer pair-wise keys for a pair of sensors to establish a secure communication session, and in the same time, they can also form communication clusters as cluster heads according to different application requirements. Internet of Things (IoT) becomes more and more popular and practical in recent years. Considering the diversity of the devices and the application scenarios, it is extremely hard to couple two devices or sub-networks with different communication and computation resources. In this thesis, we propose novel key agreement schemes based on (n,t,n) multi-secret sharing techniques for IoT in order to achieve light weighted key exchange while using Host Identity Protocol (HIP). We refer the new schemes as HIP-MEXs with different underlying multi-secret sharing techniques. We analyzed the computational and communication costs of the extremely resource constrained device which is referred to as Initiator, and CRT based HIP-MEX successfully outsource the heavy workload to the proxy, which are considered more powerful, when establishing new secret key.
Investigating the Effects of Physical Activity Counselling on Depressive Symptoms, Affect and Physical Activity in Female Undergraduate Students with Depression: A Multiple Baseline Single-Subject Design
Creators: name: McFadden, Taylor
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: exercise psychology
depression
physical activity
physical activity counselling
self-determination theory
motivational interviewing

description: Background: In Canada, women aged 15-24 report the highest rate of depression, an age group which represents a significant proportion of undergraduate students (Hanlon, 2012). Although pharmacology remains the primary treatment for depression, it may not be the most sufficient (Stanton et al., 2014). Physical activity has been demonstrated to have a large and significant antidepressant effect in individuals with depression (Schuch et al., 2016), though what remains challenging is identifying the most effective way to activate this population. Physical Activity Counselling (PAC) has been shown in research to effectively increase levels of physical activity (Fortier et al., 2011). However, the effects of PAC have not been considered in a population of female students with depression specifically. Purpose: To investigate the effects of PAC on depressive symptoms, affect and physical activity in female undergraduate students with depression. Methods: Five female undergraduate students with depression received two months of PAC from a registered Kinesiologist. The study followed a multiple baseline, single-subject design in which measures were taken during four study phases: baseline, intervention, end point and follow-up. Data was collected, including daily objective measures of physical activity, using accelerometers, and self-reported measures of depressive symptoms, positive affect, negative affect and physical activity, using online surveys administered every second day. Results: Visual analyses revealed that depressive symptoms decreased and self-reported physical activity increased from baseline throughout subsequent study phases in all five participants, as hypothesized. Statistical analyses supported these results. Estimated effect sizes of grouped averages indicated that decreases in depressive symptoms from baseline throughout each study phase ranged from small to large, while increases in self-reported physical activity were in the medium to large range. Conclusions: Findings of this study provide initial support for Physical Activity Counselling as a potential strategy to increase physical activity levels and reduce depression among female undergraduate students with depression. Future research is recommended on this important topic.
Statistical Analysis of Steady State Response in RF Circuits via Decoupled Generalized Polynomial Chaos
Creators: name: Nabavi, Seyed Ghavamoddin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Polynomial Chaos
Harmonic Balance
Decoupling Method
Intermodulation Distortion
Statistical Analysis
Galerkin Projection
RF Circuits
Steady State Analysis

description: One of the major factors in RF circuit design is the ability to predict the performance of these circuits in the presence of uncertainty in the key design parameters. This is referred to as uncertainty quantification in the mathematical literature. Uncertainty about the key design parameters arises mainly from the difficulty of controlling the physical or geometrical features of the underlying design, especially at the nanometer level. With the constant trend to scale down the process feature size, uncertainty quantification becomes crucial in shortening the design time. This thesis presents a new approach to statistically characterize the variability of the Harmonic Balance analysis and its application to Intermodulation distortion analysis in the presence of uncertainty in the design parameters. The new approach is based on the concept of Polynomial Chaos (PC) and Stochastic Galerkin (SG) methods. However, unlike the traditional PC, the proposed approach adopts a new mathematical formulation that decouples the Polynomial Chaos problem into several problems whose sizes are equal to the size of the original Harmonic Balance problem. The proposed algorithm produces significant CPU savings with equivalent accuracy to traditional Monte Carlo and standard PC approaches.
Mémoire blessée et patrimoine local : Le cas de la Basse-Ville d'Ottawa
Creators: name: Ramirez, Caroline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: géographie du patrimoine
mémoire
minorité
justice spatiale
patrimoine
densification
rénovation urbaine
Basse-Ville
Ottawa
justice patrimoniale

description: La géographie du patrimoine a eu tendance à distinguer assez radicalement l’étude des mécanismes locaux de la désignation patrimoniale de celle très symbolique des revendications commémoratives en lien avec des épisodes traumatiques, délaissant de fait la recherche, dans les conflits patrimoniaux locaux, sur l’une des sources essentielles de l’attachement territorial : la mémoire locale. Alors que la flambée des mémoires blessées et minoritaires ainsi que les processus de la construction de la mémoire nationale concentraient les chercheurs, l’échelle locale du phénomène était en effet largement délaissée. Proposant une exploration de cette piste, cette thèse s’intéresse à la mémoire entretenue et mobilisée par certains membres d’une communauté minoritaire autour de son quartier, considérablement transformé par une opération de redéveloppement et dont les dernières traces sont menacées par la densification urbaine. Selon une méthode inductive et grâce à l’analyse de différents discours portant sur le territoire, nous nous intéressons dans un premier temps à la résistance des citoyens contre la rénovation urbaine de la Basse-Ville d’Ottawa dans les années 1960 et 1970 et, dans un second temps, à la réactivation dans le cadre de conflits patrimoniaux contemporains de la mémoire de ce quartier et de sa rénovation urbaine. Le manque de reconnaissance dont fait l’objet le patrimoine du quartier est vécue aujourd’hui par certains acteurs locaux comme un double traumatisme : au souvenir réactivé de la rénovation urbaine vient s’ajouter celui de la destruction des derniers bâtiments porteurs de leur mémoire du lieu, dans un contexte de densification urbaine. Notre thèse, en apportant un nouvel éclairage sur les espaces d’expression de la mémoire du lieu en géographie du patrimoine urbain, permet d’accéder à un autre niveau de compréhension des revendications patrimoniales et d’illustrer, à l’échelle locale, la lutte pour la reconnaissance du lieu de vie fragilisé d’une communauté minoritaire. Réclamant la désignation de ses édifices porteurs de mémoire, cette lutte s’inscrit dans les grands changements observés aux échelles nationales et internationales pour une politique patrimoniale et commémorative plus inclusive de la diversité des populations : une demande de justice patrimoniale.
Micro and Nanostructuring of Polymers by Femtosecond Laser Pulses
Creators: name: Alshehri, Ali
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Material processing
Femtosecond laser
Nonlinear absorption
Selective cell growth
Alteration of wetting
Localized nanoclusters
femtosecond pulses in polymers
interaction with polymers
fs-microstructured polymers
properties by fs-pulses
fs-pulses

description: Micro/Nanostructuring of polymers by femtosecond pulses is of extreme importance because it drives applications in photonics and biomedicine. A femtosecond pulse, with an intensity of ∼ 10^13 W/cm^2, is capable of causing an optical breakdown and inducing permanent modification in the material. With such high intensity, and considering the fact that polymers possess high band gaps, the interaction nature is completely nonlinear, and the material can be modified locally on the surface and in bulk. The irradiated regions exhibit fluorescence, and they display new wetting properties as a consequence of the optical breakdown of a material. The optical breakdown can be investigated by studying the nonlinear absorption. In this thesis, we discuss the nonlinear absorption of fs-laser pulses inside polymers using transmission measurements. We show a step– function–like behaviour of the transmission, dropping abruptly to ∼ 20% at the optical breakdown threshold with a ∼ 40 % reduction in the band gap. Utilizing spectroscopy, we show that the laser-modified regions contain randomly distributed nanoclusters. The presence of localized nanoclusters is responsible for exhibiting fluorescence, within ∼ 10 µm3 for a single pulse. This feature was exploited to demonstrate high-density data storage in Polymethyl methacrylate (PMMA) without any special material preparation. We demonstrate up to 20 layers of embedded data that can be stored in a standard 120 mm disc. Storage capacity of 0.2 TBytes/disc can be achieved by adjusting read laser parameters. Besides the fluorescence capability induced in the bulk of polymers, the hydrophilicity shown by the fs–laser modified surface is utilized to study selective cell growth on the micro-structured Polydimethylsiloxane (PDMS) surface. We show that the C2C12 cells and rabbit anti-mouse protein attach preferentially to the modified regions when the surface is modified with low pulse energies. However, in the high pulse energy regime, the laser-modified regions exhibit superhydrophobicity inhibiting cell adhesion.
Barriers, Access, Resources and Knowledge: An Analysis of HIV Testing vis Women's Voices in Ottawa
Creators: name: Vannice, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: HIV

description: Women within African, Caribbean, and Black (ACB) communities are experiencing a higher burden of the HIV epidemic than other groups of women in Canada and a low uptake of HIV testing and counseling. As HIV testing is a well recognized HIV prevention strategy, increasing HIV testing within those most affected by HIV in Canada is a high priority. Therefore, this study gathers and describes the perceptions, experiences, and knowledge of HIV and HIV testing and counseling among women within ACB communities in Ottawa. These perceptions and experiences provide rich context to current barriers to HIV testing and counseling access among these groups of women; context that is utilized to ground recommendations to improve experiences of HIV testing and counseling and to increase the uptake of HIV testing and counseling among ACB women. In essence, this study provides recommendations by ACB women for ACB Women.
Additional file 1 of The impact of death and dying on surgeons in a tertiary cancer centre in Singapore
Creators: name: Tan, Si Ying
name: Tan, Jun Rong
name: Ong, Yun Ting
name: Ng, Yaoyi
name: Sinnathamby, Annushkha
name: Abdul Hamid, Nur Amira Binte
name: Ong, Simon Yew Kuang
name: Krishna, Lalit Kumar Radha
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1: Additional File 1. COREQ Checklist
Prevalence and Determinants of Food Insecurity and Its Impact on Diet Quality in African and Caribbean School-Aged Children in Ottawa
Creators: name: Tarraf, Diana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Food security
Canada
Immigrant
Socioeconomic status
Diet quality
Children

description: Purpose: Food insecurity is an important social determinant of health and is linked with higher health care costs. There is a high prevalence of food insecurity among recent immigrant households in Canada. The aim of the present project was to evaluate the prevalence of food insecurity in immigrant and non-immigrant households in Ottawa, to explore determinants of food insecurity in that population and to evaluate the link between food insecurity, diet quality and weight status. Methodology: A cross-sectional study was conducted with a convenience sample of 258 Ottawa households having a child between 6 and 12 years old, with a mother born in Sub-Saharan Africa, the Caribbean or Canada. Health Canada’s Household Food Security Survey Module was used to evaluate participants’ food access in the past 12 months. Children’s dietary intake was evaluated with the use of a 24-hour recall and a modified Healthy Eating Index diet quality score was calculated. Chi-square and logistic and linear regression analyses were used to determine correlates of food insecurity and its link with diet quality and weight status (n=249). Results: A high rate of food insecurity (39%) was found among participants. Household food insecurity was associated with low education attainment, lone motherhood, mother’s visible minority status, recent arrival to Canada, limited English fluency, reliance on social assistance, and subsidized/temporary/COOP housing. Food insecurity was associated with consumption of sweetened beverages, lower consumption of saturated fat among children, and with obesity among mothers. Conclusion: These findings suggest that food insecurity is associated with certain indicators of poor diet quality among children and with obesity among mothers. The findings also highlight the need for food insecurity to be explicitly addressed in immigrant integration strategies in order to improve the financial power of new immigrants to purchase sufficient, nutritious, and culturally acceptable foods. Enhancing immigrants’ access to affordable child care and well-paid jobs, improving social assistance programs, and providing more subsidized housing programs would be beneficial to help reduce food insecurity and increase diet quality.
Role of Mitochondrial Dynamics and Cell Death in a Dihydrotestosterone-induced Rat Model of Polycystic Ovarian Syndrome, and its Regulation by Gonadotropin
Creators: name: Mazier, Hannah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: subject: Reproduction
subject: FOS: Medical biotechnology
subject: Mitochondria

description: Polycystic ovarian syndrome (PCOS) is a multi-factorial infertility disorder whose etiology and pathogenesis is not completely understood. Although there is an association between dysregulation of mitochondrial fission and fusion to cell death (apoptotic and autophagic) and the pathogenesis of various diseases, this had not been reported in the context of granulosa cell death, follicular growth arrest and PCOS. Follicle-stimulating hormone (FSH), a granulosa cell survival factor, is used during gonadotropin therapy to assist in follicular maturation and ovulation in women with PCOS. Whether FSH can modulate the possible dysregulation of granulosa cell mitochondrial dynamics and cell death in PCOS had not been elucidated. Chemerin is an adipokine that has been associated with PCOS and granulosa cell apoptosis in follicle cultures. Its role in cell death (apoptotic and autophagic) of primary granulosa cells had not been confirmed. In this thesis, we investigated the dysregulation of granulosa cell mitochondrial dynamics in PCOS pathogenesis by using an androgenized rat model, and its modulation by exogenous gonadotropin. The mechanisms involved in gonadotropic regulation were investigated using primary granulosa cells. Our data suggest that increased mitochondrial fission leads to early antral granulosa cell death, follicular growth arrest and anovulation in women with PCOS. FSH can regulate the phosphorylation of mitochondrial fission protein Drp1, which may lead to its suppression of mitochondrial fission and apoptosis in PCOS. Finally, chemerin had no effect on cell death in granulosa cell cultures. These findings provide a greater understanding of the processes involved in PCOS pathogenesis and the regulatory role of FSH in granulosa cells, laying the foundation for future study into the development of potential biomarkers and new treatment strategies.
Somatostatin Ameliorates β-Amyloid-Induced Cytotoxicity via the Regulation of CRMP2 Phosphorylation and Calcium Homeostasis in SH-SY5Y Cells
Creators: name: Paik, Seungil
name: Somvanshi, Rishi
name: Oliveira, Helen A.
name: Zou, Shenglong
name: Kumar, Ujendra
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Somatostatin is involved in the regulation of multiple signaling pathways and affords neuroprotection in response to neurotoxins. In the present study, we investigated the role of Somatostatin-14 (SST) in cell viability and the regulation of phosphorylation of Collapsin Response Mediator Protein 2 (CRMP2) (Ser522) via the blockade of Ca²⁺ accumulation, along with the inhibition of cyclin-dependent kinase 5 (CDK5) and Calpain activation in differentiated SH-SY5Y cells. Cell Viability and Caspase 3/7 assays suggest that the presence of SST ameliorates mitochondrial stability and cell survival pathways while augmenting pro-apoptotic pathways activated by Aβ. SST inhibits the phosphorylation of CRMP2 at Ser522 site, which is primarily activated by CDK5. Furthermore, SST effectively regulates Ca²⁺ influx in the presence of Aβ, directly affecting the activity of calpain in differentiated SH-SY5Y cells. We also demonstrated that SSTR2 mediates the protective effects of SST. In conclusion, our results highlight the regulatory role of SST in intracellular Ca²⁺ homeostasis. The neuroprotective role of SST via axonal regeneration and synaptic integrity is corroborated by regulating changes in CRMP2; however, SST-mediated changes in the blockade of Ca²⁺ influx, calpain expression, and toxicity did not correlate with CDK5 expression and p35/25 accumulation. To summarize, our findings suggest two independent mechanisms by which SST mediates neuroprotection and confirms the therapeutic implications of SST in AD as well as in other neurodegenerative diseases where the effective regulation of calcium homeostasis is required for a better prognosis.
How a Collaboration Agreement Mediates the Daily Practices of Frontline Violence Against Women Workers: An Institutional Ethnography
Creators: name: Sapozhnikov, Francesca
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: collaboration
child protection
VAW agencies
institutional ethnography
listening guide approach
Ontario
domestic violence

description: While interagency collaboration among Children’s Aid Societies and violence against women (VAW) agencies have been mandated by the Ontario Ministry of Community and Social Service, little is known about these local collaboration agreements. This study seeks to explore how the Ottawa CAS/VAW Collaboration Agreement mediates the work of VAW agencies to protect women and children. Using a purposive sample, a total of eight VAW informants were interviewed. Smith (1999) argued that people’s everyday experiences are organized, often unknowingly, by the actions of people located outside the local setting and that this organization is textually-mediated. This study used institutional ethnography and the listening guide approach to critically examine the collaboration process. The results explore the narratives and standpoints as they relate to the informants’ understanding of the agreement and their descriptions of doing collaboration. This study also adopts the mapping technique developed by institutional ethnographers to map social relations. The findings indicate that informants differed in their familiarity and knowledge of the contents of the collaboration agreement – only two informants indicated that they have reviewed and read the document. The findings also show that although most informants were able to describe positive experiences of collaboration, most also described negative experiences. This study concludes that the collaboration agreement has made VAW workers’ work with women more focused and specific to helping women address Children Aid Society’s concerns. The findings demonstrate that the collaboration agreement requires an update and further research is required to evaluate these collaborations and whether they improve outcomes for women and their children.
Things Kids Think With: The Role of the Physical Properties of Mathematical Tools in Children's Learning in the Context of Addition of Fractions
Creators: name: Abtahi, Yasaman
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Zone of Proximal Development
Tools
Affordances
Fraction

description: This research was designed to examine the role of the physical properties of the mathematical tools, in children’s learning in the context of adding two fractions. My two research questions were: (1) How does the feedback from the mathematical tools play a mediating role between the physical actions of the child with respect to the mathematical affordances of the tools and the child’s thinking about and learning and knowing of solving addition of fractions problems? And (2) What role is played by mathematical tools in the emergence of a Zone of Proximal Development during the child’s solving of addition of fractions problems? To address these questions, I interviewed 13 grade 7 students in Ottawa, Ontario, in groups of two and in three rounds of 30-minute interviews per group. The results showed that the physical properties of the tools play a role in how children perceived the mathematical affordances of the tool, attached mathematical meaning to the tools, created mathematical artefacts and solved the addition of fractions problems. Moreover, the findings show that in children’s interactions with mathematical tools, at times, the Zone of Proximal Development (ZPD) emerged, with the guidance provided by the tools. I conclude that children’s interaction with the tools provided them the possibility of learning newer forms of reflections, expressions and actions in relation to adding two fractions. This learning was a result of a complex and intertwined relationship between the immediate physical properties and affordances of the tool, the traces of the thoughts of the designer of the tools, as well as the children’s previous knowing of fractions. With this study, I extend the Vygotskian notion of the more knowledgeable other within the ZPD to include not only agents (children and adults) but also tools.
Additional file 2 of The impact of death and dying on surgeons in a tertiary cancer centre in Singapore
Creators: name: Tan, Si Ying
name: Tan, Jun Rong
name: Ong, Yun Ting
name: Ng, Yaoyi
name: Sinnathamby, Annushkha
name: Abdul Hamid, Nur Amira Binte
name: Ong, Simon Yew Kuang
name: Krishna, Lalit Kumar Radha
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 2: Additional File 2. Interview Guide
Rational Points and Zeta Functions of Humbert Surfaces with Square Discriminant
Creators: name: Shaska, Elira
name: Mello, Jorge
name: Salami, Sajad
name: Shaska, Tony
Publisher: name: arXiv
Year: 2025
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: This paper examines the arithmetic of the loci \(\cL_n\), parameterizing genus 2 curves with \((n, n)\)-split Jacobians over finite fields \(\F_q\). We compute rational points \(|\cL_n(\F_q)|\) over \(\F_3\), \(\F_9\), \(\F_{27}\), \(\F_{81}\), and \(\F_5\), \(\F_{25}\), \(\F_{125}\), derive zeta functions \(Z(\cL_n, t)\) for \(n = 2, 3\). Utilizing these findings, we explore isogeny-based cryptography, introducing an efficient detection method for split Jacobians via explicit equations, enhanced by endomorphism ring analysis and machine learning optimizations. This advances curve selection, security analysis, and protocol design in post-quantum genus 2 systems, addressing efficiency and vulnerabilities across characteristics.
STATISTICAL BASED MEDIA OPTIMIZATION AND PRODUCTION OF CLAVULANIC ACID BY SOLID STATE FERMENTATION IN JACKFRUIT SEED POWDER AS NOVEL SUBSTRATE USING STREPTOMYCES CLAVULIGERUS MTCC 1142
Creators: name: Basavaraj .M. Vastrad
Publisher: name: Zenodo
Year: 2024

description: Statistics based optimization, Plackett–Burman design (PBD) and response surface methodology(RSM) were employed to screen and optimize the media components for the production ofclavulanic acid from Streptomyces clavuligerus MTCC 1142, using solid state fermentation. jackfruitseed powder was used as both the solid support and carbon source for the growth of Streptomycesclavuligerus MTCC 1142. Based on the positive influence of the Pareto chart obtained from PBD onclavulanic acid production, five media components – yeast extract, beef extract, sucrose, malt extractand ferric chloride were screened. Central composite design (CCD) was employed using these fivemedia components- yeast extract 2.5%, beef extract 0.5%, sucrose 2.5%, malt extract 0.25% and ferricchloride nutritional factors at three levels, for further optimization, and the second order polynomialequation was derived, based on the experimental data. Response surface methodology showed thatthe concentrations of yeast extract 2.5%, beef extract 0.5%, sucrose 2.5%, malt extract 0.25% and ferricchloride 2.5% were the optimal levels for maximal clavulanic acid production (19.37 mg /gds) whichwere validated through experiments.
Examining Parkinson’s Disease Linked DJ-1 and its Interaction with Autophagy Related ATG5 and ATG12 & Understanding PINK1’s Functional Interaction with Mitochondrial m-AAA Protease AFG3L2
Creators: name: Seegobin, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017

description: Mutations in DJ-1 and PTEN-induced putative kinase 1 (PINK1) have been linked to familial early-onset Parkinson’s disease. However, their functional role is not well understood. Through a mass-spectrometry screen we identified protein interaction candidates ATG5 and ATG12 for DJ-1 and AFG3-like AAA ATPase 2 (AFG3L2) for PINK1. Examination of ATG5, ATG12, and DJ-1 by co-immunoprecipitation through multiple methods, did not validate the interaction. In contrast, the interaction between m-AAA protease AFG3L2 and PINK1 was validated. AFG3L2 selectively stabilized and can differentially cleave PINK1 in-vitro. We observed endogenous mitophagy in AFG3L2 null cells. Furthermore, we elucidated a novel function of mitochondrially-targeted PINK1 fragments in rescuing endogenous mitochondrial fragmentation, increasing both mitochondrial length and networking. Although further examination is needed, these studies provide a greater understanding of the functional interaction between PINK1 and AFG3L2 and provide evidence that DJ-1, ATG5 and ATG12 may not interact.
Additional file 1 of “We’re living in a world that wasn’t built for us”: A qualitative exploration of young New Zealander’s perspectives on socio-ecological determinants of declining youth mental health
Creators: name: Stubbing, Jessica
name: Gibson, Kerry
name: Bardsley, Anne
name: Gluckman, Peter
Publisher: name: figshare
Year: 2025
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 1
Guiding Students to Pursue French: The Guidance Counsellor’s Perspective in the Decision to Continue FSL
Creators: name: McGregor, Jessica
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: guidance counsellor
course selection
French as a second language
retention
attrition

description: This exploratory case study investigated the role secondary school guidance counsellors believed they played in the course selection process, especially regarding the continuation of French as a second language (FSL). As new initiatives have been recently introduced to increase retention in all FSL programs throughout Ontario (OME, 2013a), this study also sought to identify the factors guidance counsellors believed contributed to students continuing (or not continuing) the study of FSL past the mandatory Grade 9 credit. The following research questions guided this study: (1) How do guidance counsellors describe the process of course selection, with regards to FSL in particular?; (2) How do guidance counsellors view their role in the course selection process?; and (3) What do guidance counsellors identify as factors that contribute to students continuing (or not continuing) the study of FSL past Grade 9? Individual semi-structured interviews were conducted with 14 guidance counsellors from 12 schools across one school board in Ontario. Analysis of the insights shared by guidance counsellors highlight the complexities of the course selection process, as well as the strategies and tools they each used to prepare students to make the most informed decisions regarding their course selection. When counselling students about continuing optional FSL courses after Grade 9, participants expressed that they would encourage the pursuit of FSL courses, if the topic was student initiated. Emerging evidence showed that core French and French immersion students were counselled differently, with the latter receiving more attention if they expressed a desire to leave the program. Finally, guidance counsellors identified a wide variety of reasons they believed affected retention and attrition rates at their schools, with the most common being for future employment purposes and not seeing the value in learning French.
Female Identity and Agency in the Cult of the Martyrs in Late Antique North Africa
Creators: name: Barkman, Heather
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Women
Martyrs
Late Antiquity
North Africa

description: This thesis investigates the dual roles that women played in the cult of the martyrs in Christianity in Late Antiquity: as martyrs worthy of admiration and as venerators engaged in acts of celebration. The investigation is driven by questions regarding the identity, agency, and power of women in the cult of martyrs, focusing on late antique (second- to fifth-century) North Africa. Late antique Christians expressed their veneration of the martyrs in a variety of ways, including (but not limited to) special church services, praying for the martyrs, visiting martyrs’ shrines to ask for miracles (often healing in nature), and partaking in commemorative feasts at the martyrs’ graves on the anniversaries of their deaths. In all of these modes of veneration, women took on various roles that were analogous with other roles outside of the cult of the martyrs, such as wife, mother, patron, or client. Female martyrs are also identified using these roles, and thus this provides a useful area of comparison. By exploring these roles, this thesis arrives at a more nuanced understanding of women’s agency and power in traditional contexts and how such agency and power were transferred, continued, and challenged within the cult of the martyrs. The thesis engages in textual and discourse analysis of the relevant primary sources, particularly the martyr texts, sermons, letters, and treatises by North African writers. In the secondary literature, this study engages with the diverse works of classicists, historians, archaeologists, religious studies scholars, and feminist theorists. The interdisciplinary approach of the thesis is further nuanced by an examination of the concepts of identity, agency, and power. Applying these analyses to the context of women’s participation in the cult of the martyrs provides new insights into how we can uncover women’s experiences in ancient sources, where women’s voices are almost always obscured by male discourses.
Educational Park Planning in Berkeley, California, 1965-1968
Creators: name: Brillinger, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Educational Parks
Desegregation
Berkeley, California

description: Promoted as state-of-the-art desegregation devices, educational parks were large campus-like schools designed and sited to draw students from many neighborhoods. In the mid-1960s, the educational park movement featured prominently in debates about race and education in the United States, winning the support of numerous influential individuals and organizations, yet today the educational park movement is nearly forgotten, akin to a wave that swelled, crested, and crashed, leaving only a muddy wash. How could so many thoughtful and energetic people—1960s educational park advocates—work so hard yet achieve so little? This question can only be answered by reference to a wide-ranging 1960s debate about the appropriate role of the federal government in public education, a debate during which educational parks became emblematic of a federal government intent on remaking public schools to advance its own socially progressive ends. Whereas advocates for an expanded federal role in public education portrayed educational parks as cutting-edge alternatives to outdated and inequitable neighborhood schools, opponents of federalism in education presented the parks as staging areas for federal invasions of old-line school districts. In the end it was the latter vision—with its scenes of federal officials revising textbooks and drawing up lesson plans—that won the day, transforming educational parks into menacing symbols of federal overreach.