title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾ÐµÐºÑÐ° Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° ÑÑÐ±ÑÑÐ°Ð½ÑÐ¸Ð¸ ÑÐµÐºÐ¾Ð¼Ð±Ð¸Ð½Ð°Ð½ÑÐ½Ð¾Ð³Ð¾ Ð°Ð½ÑÐ¸ÑÐµÐ»Ð° ÑÐºÑÐ»Ð¸Ð·ÑÐ¼Ð°Ð±
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The Development of the project of recombinant antibody eculizumab substance production
Creators: name: ÐÐ¾Ð¹Ð²Ð¸ÑÑÐ¾Ð¹Ð½ÐµÐ½, ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð±Ð¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð±Ð¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾
ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¼Ð¾Ð½Ð¾ÐºÐ»Ð¾Ð½Ð°Ð»ÑÐ½ÑÐµ Ð°Ð½ÑÐ¸ÑÐµÐ»Ð°
Ð¿Ð°ÑÐ¾ÐºÑÐ¸Ð·Ð¼Ð°Ð»ÑÐ½Ð°Ñ Ð½Ð¾ÑÐ½Ð°Ñ Ð³ÐµÐ¼Ð¾Ð³Ð»Ð¾Ð±Ð¸Ð½ÑÑÐ¸Ñ
Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð°
ÑÐºÑÐ»Ð¸Ð·ÑÐ¼Ð°Ð±
biotechnological equipment
biotechnological production
cultivation
monoclonal antibodies
paroxysmal nocturnal hemoglobinuria
production planning
eculizumab

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description: This work is dedicated to the projecting technological stages of cultivation of monoclonal antibody eculizumab production. The project describes the preparatory stages and the stages of getting seed material and product cultivation. Tasks that have been accomplished in the work: 1) To study one of the existing technologies of the production of recombinant monoclonal antibody eculizumab. 2) To develop and describe the technological schemes of the cultivation process, namely the stages of preparation of complete nutrient medium, obtaining seed material and cultivation in an axial bioreactor. 3) Calculate and select the appropriate main and auxiliary equipment. 4) Analyze the safety of the technological process of the stages developed by the project. The object of research - the project of the planning production area of biosynthesis of pharmaceutical preparations based on Pharmasintez-Nord JSC, St. Petersburg. The diploma project includes: characteristic of the final pharmaceutical preparation; characteristic and selection with justification; selection with justification of the production technology, short characteristic of the place of production; characteristic of raw materials and supplies; block scheme of the production process; technological schemes and description of the separate stages; material calculations of the stages; selection of the technological equipment, its description and justification; safety assessment of the projected production; layout solutions; economic substantiation of the project; calculation of the project efficiency indicators; evaluation of the economic efficiency of investments. The databases were used in review the literature: Google Academy, www.pravo.gov.ru, EBS Lan, RNB, eLIBRARY.RU, Scopus, www.pharmaceutical-technology.com, pubmed.ncbi.nlm.nih.gov. Statistical data was processed in Statistica and Microsoft Office software package.