title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐ¾Ð¼Ð±Ð° Ð² Ð¼Ð¸ÐºÑÐ¾ÑÐ¾ÑÑÐ´Ð°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Modeling and experimental investigation of the process of clot formation in microvessels
Creators: name: Ð¢ÐµÑÐµÑÐµÐ½ÐºÐ¾Ð²Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð¼Ð¸ÐºÑÐ¾ÑÐ»ÑÐ¸Ð´Ð¸ÐºÐ°
Ð¼Ð¸ÐºÑÐ¾ÑÐ»ÑÐ¸Ð´Ð½ÑÐ¹ ÑÐ¸Ð¿
Ð¾ÑÐ³Ð°Ð½-Ð½Ð°-ÑÐ¸Ð¿Ðµ
Ð³ÐµÐ¼Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ°
ÑÑÐ¾Ð¼Ð±Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ
ÑÑÐ½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
microfluidics
microfluidic chip
organ-on-a-chip
hemodynamics
clot formation
bypass grafting

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð¼Ð°ÑÑÐ¾Ð¿ÐµÑÐµÐ½Ð¾ÑÐ° Ð²ÐµÑÐµÑÑÐ²Ð° Ð² Ð¼Ð¸ÐºÑÐ¾ÐºÐ°Ð½Ð°Ð»Ð°Ñ Ð¿ÐµÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸Ð¸, Ð¸Ð¼Ð¸ÑÐ¸ÑÑÑÑÐ¸Ñ ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð¾ Â«ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÐ¹ ÑÐ¾ÑÑÐ´-Ð½Ð°-ÑÐ¸Ð¿ÐµÂ». ÐÐ»Ñ Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð¼Ð°ÑÑÐ¾Ð¿ÐµÑÐµÐ½Ð¾ÑÐ° Ð²ÐµÑÐµÑÑÐ²Ð° Ð² Ð¼Ð¸ÐºÑÐ¾ÐºÐ°Ð½Ð°Ð»Ðµ Ð±ÑÐ»Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð´Ð²Ðµ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸, Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½ÑÐµ Ð½Ð° Ð´Ð²ÑÑ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð³Ð¸Ð¿Ð¾ÑÐµÐ·Ð°Ñ: ÑÐ¿Ð»Ð¾ÑÐ½Ð¾Ð¹ ÑÑÐµÐ´Ñ Ð¸ Ð´Ð¸ÑÐºÑÐµÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐ¾ÐºÐ° ÑÐ°ÑÑÐ¸Ñ. Ð§Ð¸ÑÐ»ÐµÐ½Ð½ÑÐµ ÑÐ°ÑÑÑÑÑ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ÑÑ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¹ ÑÑÐµÐ´Ðµ COMSOL Multiphysics, Ð¾ÑÐ½Ð°ÑÐµÐ½Ð½Ð¾Ð¹ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼ÑÐ¼ Ð¼Ð¾Ð´ÑÐ»ÐµÐ¼ Ð¼Ð¸ÐºÑÐ¾Ð³Ð¸Ð´ÑÐ¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸. ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð°Ñ Ð¿ÑÐ¾Ð²ÐµÑÐºÐ° Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ñ Ð½Ð° Ð±Ð°Ð·Ðµ ÐÐ½ÑÑÐ¸ÑÑÑÐ° Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¸Ð±Ð¾ÑÐ¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ Ð ÐÐ, Ð³Ð´Ðµ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¼ÑÐ³ÐºÐ¾Ð¹ Ð»Ð¸ÑÐ¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð±ÑÐ»Ð¸ Â Ð¸Ð·Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ñ Ð¼Ð¸ÐºÑÐ¾ÑÐ»ÑÐ¸Ð´Ð½ÑÐµ ÑÐ¸Ð¿Ñ (Ð²ÑÐµÐ³Ð¾ 20 ÑÑÑÐº), Ð¸Ð¼Ð¸ÑÐ¸ÑÑÑÑÐ¸Ðµ ÐºÑÐ¾Ð²ÐµÐ½Ð¾ÑÐ½ÑÐµ ÑÐ¾ÑÑÐ´Ñ. ÐÐ²Ð¸Ð¶ÐµÐ½Ð¸Ðµ Ð¿Ð¾ÑÐ¾ÐºÐ¾Ð² Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸ Ð¿Ð¾ Ð¼Ð¸ÐºÑÐ¾ÐºÐ°Ð½Ð°Ð»Ð°Ð¼ ÑÐ¸Ð¿Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð¾ÑÑ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÐ¾Ð½ÑÐ¾ÐºÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð° Leica. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ, Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¾Ð±Ð¾Ð¸Ñ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð² Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¾, ÑÑÐ¾ ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸Ðµ ÑÐ³Ð»Ð° Ð°Ð½Ð°ÑÑÐ¾Ð¼Ð¾Ð·Ð° Ð¿Ð¾Ð²ÑÑÐ°ÐµÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÑÐ½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ. ÐÐ¾Ð»ÑÑÐµÐ½Ñ ÑÐ°ÑÑÑÑÐ½ÑÐµ Ð¾ÑÐµÐ½ÐºÐ¸ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ Ð²ÐµÐ»Ð¸ÑÐ¸Ð½ Ð¿Ð¾ÑÐ¾ÐºÐ¾Ð² Ð½Ð° Ð²ÑÑÐ¾Ð´Ðµ ÐºÐ°Ð½Ð°Ð»Ð¾Ð² Ð´Ð»Ñ ÑÐ°Ð·Ð½ÑÑ ÑÐ³Ð»Ð¾Ð² Ð°Ð½Ð°ÑÑÐ¾Ð¼Ð¾Ð·Ð°. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð°Ñ Ð¿ÑÐ¾Ð²ÐµÑÐºÐ° Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð»Ð°Ð¼Ð¸Ð½Ð°ÑÐ½Ð¾ÑÑÐ¸ ÑÐµÑÐµÐ½Ð¸Ñ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸ Ð² ÐºÐ°Ð½Ð°Ð»Ðµ Ð¸ ÑÐ°Ð²Ð½Ð¾Ð¼ÐµÑÐ½Ð¾ÑÑÐ¸ ÑÐ°ÑÑÐ¾Ð´Ð¾Ð² Ð² Ð¾ÑÐ²ÐµÑÐ²Ð»ÐµÐ½Ð¸ÑÑ Ð¾Ð´Ð¸Ð½Ð°ÐºÐ¾Ð²Ð¾Ð¹ Ð³ÐµÐ¾Ð¼ÐµÑÑÐ¸Ð¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð² Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ðµ Ð¼Ð¾Ð¶Ð½Ð¾ Ð±ÑÐ´ÐµÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¹ Ð´Ð»Ñ ÐºÐ°ÑÐ´Ð¸Ð¾ÑÐ¸ÑÑÑÐ³Ð¾Ð².Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐ±Ð»Ð¸ÐºÐ¾Ð²Ð°Ð½Ñ Ð² ÑÐµÐ·Ð¸ÑÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ð¸ Â«ÐÐµÐ´ÐµÐ»Ñ Ð½Ð°ÑÐºÐ¸ ÐÐ­ÐÐ¢ 2021Â», Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³, 15-19 Ð½Ð¾ÑÐ±ÑÑ Ð¸ Ð²ÐºÐ»ÑÑÐµÐ½Ñ Ð² Ð¾ÑÑÐµÑ ÐÐ°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð¼ÐµÑÐ¸ÑÐµÐ»ÑÐ½ÑÑ Ð±Ð¸Ð¾- Ð¸ ÑÐµÐ¼Ð¾ÑÐµÐ½ÑÐ¾ÑÐ½ÑÑ Ð¼Ð¸ÐºÑÐ¾ÑÐ¸ÑÑÐµÐ¼ ÐÐ½ÑÑÐ¸ÑÑÑÐ° Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¸Ð±Ð¾ÑÐ¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ (Ð²ÑÑÐ¾Ð´Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ Ð² ÑÐ°Ð±Ð». 1 Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ).
description: The given work is devoted to the study of the substance mass transfer process in the microchannels of variable geometry, imitating the device "blood-vessel-on-a-chip". In order to describe the processes of mass transfer of substance in the microchannel, two mathematical models based on two different hypotheses were proposed: a continuous medium and a discrete flow of particles. Numerical calculations were performed in the COMSOL Multiphysics software equipped with the necessary microfluidics module. Modeling and experimental verification of the models were undertaken at the Institute of Analytical Instrumentation of the Russian Academy of Sciences, where microfluidic chips that simulate blood vessels (20 units in total) were fabricated by soft lithography. The movement of fluid flows in the chip microchannels was studied with a Leica confocal microscope.As a result, simulations of both approaches showed that decreasing the angle of the anastomosis enhances the efficiency of bypass. Calculated values of the ratio of fluxes at the channel outlet for different angles of the anastomosis were obtained. Experimental verification of mathematical models for fluid flow laminarity in the channel and distribution of flow rates in junctions of the same geometry is performed. The obtained data can be used as recommendations for cardiovascular specialists in future.The results of the research were published in the theses of the conference "IEIT Science Week 2021", St. Petersburg, November 15-19 and included in the report of the Laboratory of Information-Measuring Bio- and Chemosensor Microsystems of the Institute of Analytical Instrumentation (the output data is given in table 1 of the appendix).