cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sustained release gel (polymer-free) of itraconazole-loaded microemulsion for oral candidiasis treatment: time-kill kinetics and cellular uptake
Creators: name: Tubtimsri, Sukannika
name: Weerapol, Yotsanan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified

description: Itraconazole (ICZ) was prepared in a self-microemulsifying (SM) gel. This gel was intended for use in the oral mucosa, where low volume and flow of saliva result in limited solubility and absorption of drugs that are poorly water-soluble. The drug-loaded gel formulation (ICZ-SM) was selected as a clear solution in the ternary phase diagram to improve the solubility of ICZ. Seven ratios (S1–S7) were prepared by mixing polyoxyl 35 castor oils (P35), a medium chain with a blend of mono-, di-, and triglycerides (MCT), and water. Phase separation of large-sized emulsions by countering with artificial saliva were observed in dilution tests for the formulation contained MCT, P35, and water at the ratios of 70:20:10 (S1), 10:80:10 (S3), and 20:60:20 (S4). Formulations in the ratios of 15:50:35 (S5) and 19:43:38 (S6) produced strong ICZ-SM gels, as shown by rheology tests, whereas the formulations at the ratios of 30:60:10 (S2) and 10:43:47 (S7) exhibited no elasticity. A model of zero-order kinetic (S5) and first-order kinetic (S6) were found to best fit the release kinetics of ICZ from the gels. Time-killing assays revealed that S5 and S6 required less time compared with S2 and the ICZ solution. Furthermore, S5 exhibited the highest increase in cell uptake compared with S2, S6, and the ICZ solution. These findings suggest that the ICZ-SM gel was a free polymer capable of delivering an ICZ for the treatment of oral candidiasis, and that ICZ-SM gels applied locally exhibit enhanced absorption into cells.
title: Investigation of Nickle as a Matrix Modifier in the Atomic Absorption Analysis of Tin
Creators: name: Saunders, Charles William
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1986

description: Nickel has been widely used as a matrix modifier in the flameless atomic absorption analysis of arsenic and selenium. Its utility as a modifier for tin has been investigated using Polarized Zeeman effect Graphite Furnace Atomic Absorption Spectroscopy. Peak area, peak shape, and appearance times were compared in modified and nonmodified standards using the system computer's internal integration and a detector/readout system with 18 msec resolution.

The addition of nickel at 600 mg/L increased the tin absorbance signal five-fold. The improved signal to noise ratio resulted in a two-fold increase in the sensitivity and a lower limit of detection. The appearance time of the signal, defined as generation of ten percent of the peak height, was delayed by 30 percent, and the peaks were more symmetric. The appearance temperature of the nickel modified signal was 700 K higher than when no nickel was present. The precision of the analysis, both within a run and between runs, is improved by the addition of nickel. A mechanism to account for the altered atomization profile is proposed using the aid of Arrhenius plots.

The effect of the modifier in the presence of interfering salts was examined. Sodium and potassium sulfates exhibited severe depression of the tin signal when present at low ppm concentrations, an effect which was eliminated by the addition of nickel at 600 mg/L. Ferric chloride exhibited a progressive enhancement of the signal, an effect also eliminated by the addition of nickel. Aluminum nitrate and aluminum chloride each exhibited a more erratic and less reproducible enhancement which was reduced but not eliminated by the addition of nickel. Sulfuric acid had a mild depressive effect on the signal which was unaffected by the presence of nickel. The relative standard deviations of the measurements in these matrices was improved at virtually every level tested.
Preparation and in vivo evaluation of an intravenous emulsion loaded with an aprepitant-phospholipid complex
Creators: name: Li, Yan
name: Yin, Hong
name: Wu, Chensi
name: He, Jia
name: Wang, Chunyan
name: Ren, Bo
name: Wang, Heping
name: Geng, Dandan
name: Zhang, Yirong
name: Zhao, Ligang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences

description: In present, there was no detailed report on the formulation optimization and quality evaluation of aprepitant (APT) injectable lipid emulsion (APT-IE). The aim of the present investigation was to prepare and evaluate its properties of APT-IE loaded with an APT phospholipid complex (APT-PC) in vitro and in vivo. APT-PC was obtained by solvent evaporation with APT and phospholipids, then analyzed by X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. Lipid emulsions are a new formulation that can reduce side effects and improve drug loading. APT-IE prepared by High-pressure homogenization and optimized by response surface methodology (RSM). The proportion of sodium oleate, poloxamer 188 and soybean oil were selected as variables for the optimization. The optimal formulation of ATP-IE had the following characteristics: particle size, 82.83 ± 1.89 nm; polydispersity index, 0.243 ± 0.008; zeta potential, −59.0 ± 2.54 mV; encapsulation efficiency, 98.84%±1.43%; drug loading, 7.08 ± 0.16 mg/mL; and osmotic pressure, 301 ± 2.15 mOsmol/kg. Transmission electron microscopy images indicated that the particle diameter of APT-IE was approximately 100 nm, with a morphology of spheroidal or spherical. APT-IE exhibited sufficient stability after storage at 4 ± 2 °C for more than 6 months. The results of the pharmacokinetic study demonstrated that APT-IE had the advantages of better safety, higher bioavailability, and obvious liver targeting than APT solution (APT-SL). The area under the curve (AUC) of APT-IE was 3-fold enhanced compared with APT-SL. The targeted enhancement multiple of APT-IE to liver tissue was greater than that of APT-SL. These results suggested that APT-IE has broad clinical application and industrial production potential.
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy
Creators: name: Tu, Yaqin
name: Zhang, Wei
name: Fan, Guorun
name: Zou, Chenming
name: Zhang, Jie
name: Wu, Nan
name: Ding, Jiahui
name: Zou, Wen Qing
name: Xiao, Hongjun
name: Tan, Songwei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Cancer

description: High intracellular reactive oxygen species (ROS) level is characteristic of cancer cells and could act as a target for the efficient targeted drug delivery for cancer treatment. Consequently, biomaterials that react to excessive levels of ROS are essential for biomedical applications. In this study, a novel ROS-responsive polymer based on D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and poly (β-thioester) (TPGS-PBTE) was synthesized for targeted delivery of the first-line antineoplastic drug, paclitaxel (PTX). The resultant TPGS-PBTE NPs showed good ROS-responsive capability in size change and drug release. Compared to PTX, PTX-loaded nanoparticles (PTX@TPGS-PBTE NPs) showed enhanced cytotoxicity and higher level of apoptosis toward squamous cell carcinoma (SCC-7) cells. Tumor-targeted delivery of the NPs was also observed, especially after being modified with a tumor-targeting peptide, cRGD. Enhanced tumor growth inhibition was also observed in head and neck cancer SCC-7 murine models. In summary, PTX@TPGS-PBTE NPs can achieve good therapeutic effects of PTX against head and neck cancer both in vitro and in vivo, especially when modified by cRGD for active targeting, which enriched the application of ROS responsive system utilized in the delivery of anticancer drugs.
Impact of the Cambridge Zero-Cambridge Colleges (CZ-CC) Sustainable Food Initiative on food policies and practices across the 31 Colleges of the University of Cambridge: protocol for an observational study
Creators: name: Reisch, Lucia A.
name: Ball, Tom
name: White, Nick
name: Munro-Faure, Amy
name: Alberti, Caroline
name: Higney, Ivan
name: Marteau, Theresa Mary
name: Balmford, Andrew
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Environmental Studies
subject: Social and Behavioral Sciences
subject: Food Studies

description: Aim To assess the extent to which four actions are implemented in all 31 Colleges by October 2026: i. Increasing the proportion of plant-based (vegan) meals offered within Colleges with a view to these being at least 50% of meals offered. ii. Reducing ruminant meats (beef, lamb, venison) offered with a view to phasing them out. iii. Serving only sustainably sourced seafood. iv. Reducing food waste by 50%. These four actions have been prioritised by the Cambridge Zero-Cambridge Colleges (CZ-CC) Sustainable Food Initiative based on evidence that together they could achieve the largest reductions in greenhouse gas emissions and other harmful environmental impacts generated by the food system across the University. Method Phase I of the study comprises a survey to be sent to all 31 Colleges of the University of Cambridge with three aims: a) to describe current practices and policies relating to food sustainability in Colleges b) to assess the acceptability and feasibility of the four evidence-based priority actions to increase the sustainability of food practices in Cambridge Colleges c) to ascertain data availability on outcome measures planned for the evaluation of the CZ-CC Initiative in Phase II of the study. The results will inform the intervention and outcome measures for Phase II of the study. Phase II is an observational study assessing: a. the extent to which the four priority actions identified by the Cambridge Zero-Cambridge Colleges Initiative on Sustainable Food are implemented; b. the emissions reductions achieved. Colleges will be supported to implement these actions through the provision of an evidence-based guidance document together with a programme of events, organized by the CZ-CC Initiative, and bespoke support, as needed. The main outcomes are: 1. Proportion of plant-based (vegan) meals offered 2. Use of ruminant meat 3. Proportion of seafood offered from a sustainable source 4. Reduction in proportion of food wasted 5. Greenhouse gas emissions from food purchased Contribution The results from Phases I and II of the study can inform the design of other sustainable food strategies in higher education institutions and other organisations. The mode of working could also inform models for change on other topics in similar settings.
Additional file 12 of DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
Creators: name: Zhou, Jing-dong
name: Zhao, Yang-jing
name: Leng, Jia-yan
name: Gu, Yu
name: Xu, Zi-jun
name: Ma, Ji-chun
name: Wen, Xiang-mei
name: Lin, Jiang
name: Zhang, Ting-juan
name: Qian, Jun
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12. Confirmation of BP1 overexpression after BP1 transfection in K562 cells detected by western blot (original figure).
The probability of multidimensional poverty in the European Union
Creators: name: Liberati, Paolo
name: Resce, Giuliano
name: Tosi, Francesca
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2020
Subjects: SECS-P/03 Scienza delle finanze
SECS-S/05 Statistica sociale

description: This paper evaluates multidimensional poverty in European countries introducing two main novelties compared with the previous literature: first, the dimensions of poverty are selected on the basis of the shared values included in the Charter of Fundamental Rights of the European Union; second, the whole space of feasible weights is used to summarise the multidimensional information, in order to remain agnostic about the importance given to the different deprivations. Using data from four waves of EU-SILC, the methodological innovations introduced here have allowed to produce a family of measures that capture the individual probability of being multidimensionally poor. Individual probabilities are then used to analyse the within and between distribution of multidimensional poverty in ten countries. Finally, they get combined with the generalised Lorenz dominance techniques in order to derive socially preferred distributions with the minimum load of value judgments. The novel methods proposed in this analysis allow to move from a dual definition of poverty, where poor and non-poor individuals are classified in a mutually exclusive context, to a continuous measure of deprivation, which allows to capture both the extensive and intensive margin of multidimensional poverty.
Additional file 10: of Negative correlation between rates of molecular evolution and flowering cycles in temperate woody bamboos revealed by plastid phylogenomics
Creators: name: Ma, Peng-Fei
name: Vorontsova, Maria
name: Olinirina Nanjarisoa
name: Razanatsoa, Jacqueline
name: Guo, Zhen-Hua
name: Haevermans, Thomas
name: Li, De-Zhu
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Relative plastid rate of molecular evolution among the lineages of Arundinarieae from Bayesian analysis under the lognormal uncorrelated relaxed clock (LURC) model. Branch thickness is proportional to the inferred median rate for the branch with detail numbers. (PDF 372Â kb)
PERSPECTIVA FUNCIONALISTA DO CRIME NA ATIVIDADE MÉDICA
Creators: name: Márcio José Calaça da Silva Junior
name: Isadora Dar'c Davi de Souza
name: Katyane Tabosa Mendes da Silva
name: Antonio de Pádua Vieira Cavalcanti
name: Adriana Conrado de Almeida
Publisher: name: Zenodo
Year: 2022

description: RESUMO

 

O presente artigo teve como objetivo abordar o direito penal médico sob a ótica do nexo causal apresentado pelas teorias funcionalistas do crime. Para tanto, foi realizado um estudo aprofundado do Nexo Causal do Tipo Penal segundo as teorias Causalistas e Finalista, cotejando seus resultados com os das teorias Funcionalistas baseadas na Imputação Penal Objetiva. No mais, para situar o leitor sobre os principais conceitos que orbitam sobre o tema, exploramos diversos conceitos relacionados à atividade médica. Cotejadas as teorias tradicionais aplicáveis à teoria geral do crime com Teoria da Imputação Penal Objetiva, verificamos que, de fato, elas encontram-se defasadas e não conseguem se adequar ao fenômeno moderno de uma sociedade “de riscos”. Uma das principais deficiências dessas teorias tradicionais foi não conseguir explicar de forma satisfatória a relação de causalidade nos crimes culposos. Em conclusão, reconhece-se que a Teoria da Imputação Objetivo não está atualmente apta para substituir tradicionais teorias do crime como uma “Teoria Geral do Delito” no Brasil. Porém, há uma diversificada gama de soluções trazidas pela imputação objetiva e que já vêm sendo aplicadas por nossos tribunais de forma exitosa. Na seara médica, com sua predominância de crimes culposos, são verificados os exemplos mais bem sucedidos de repercussão positiva da Teoria da Imputação Objetiva.

 

Palavras-Chave: teoria da imputação penal objetiva, direito penal médico, nexo causal.
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Creators: name: Nousheen, Kainat
name: Din, Fakhar Ud
name: Jamshaid, Humzah
name: Afza, Rabia
name: Khan, Saif Ullah
name: Malik, Maimoona
name: Ali, Zakir
name: Batool, Sibgha
name: Zeb, Alam
name: Yousaf, Abid Mehmood
name: Almari, Ali H.
name: Alqahtani, Saud
name: Khan, Salman
name: Khan, Gul Majid
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Herein we designed, optimized, and characterized the Metformin Hydrochloride Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin Hydrochloride loaded Transethosomal gel (MTF-TES gel) that provides a sustained release, improved transdermal flux and improved antidiabetic response of MTF. Design Expert® software (Ver. 12, Stat-Ease, USA) was applied for the statistical optimization of MTF-TES. The formulation with Mean Particle Size Distribution (MPSD) of 165.4 ± 2.3 nm, Zeta Potential (ZP) of −21.2 ± 1.9 mV, Polydispersity Index (PDI) of 0.169 ± 0.033, and MTF percent Entrapment Efficiency (�) of 89.76 ± 4.12 was considered to be optimized. To check the chemical incompatibility among the MTF and other formulation components, Fourier Transform Infrared (FTIR) spectroscopy was performed and demonstrated with no chemical interaction. Surface morphology, uniformity, and segregation were evaluated through Transmission Electron Microscopy (TEM). It was revealed that the nanoparticles were spherical and round in form with intact borders. The fabricated MTF-TES has shown sustained release followed by a more pronounced effect in MTF-TES gel as compared to the plain MTF solution (MTFS) at a pH of 7.4. The MTF-TES has shown enhanced permeation followed by MTF-TES gel as compared to the MTFS at a pH of 7.4. In vivo antidiabetic assay was performed and results have shown improved antidiabetic potential of the MTF-TES gel, in contrast to MTF-gel. Conclusively, MTF-TES is a promising anti-diabetic candidate for transdermal drug delivery that can provide sustained MTF release and enhanced antidiabetic effect.
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation
Creators: name: Adin, Syeda Nashvia
name: Gupta, Isha
name: Rashid, Md Abdur
name: Alhamhoom, Yahya
name: Aqil, Mohd
name: Mujeeb, Mohd
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: The present research study limns the preparation of MNF loaded transethosomes (MNF-TE) to improve MNF solubility, bioavailability and permeation through skin layers for transdermal delivery. MNF-TE was formulated using thin-film hydration method and optimization was done using Box-Behnken design (BBD). MNF-TEopt was characterized for Polydispersity index (PDI), vesicle size, entrapment efficiency, zeta potential and in vitro MNF release. For further evaluation, Pharmacokinetic study, Transmission electron microscopy (TEM), Skin permeation study and Confocal scanning laser microscopy (CLSM) were performed withal. The MNF-TEopt presented spherical and sealed shape vesicles with small vesicle size of 148.6 nm, entrapment efficiency of 74.23%, PDI of 0.1139 and in vitro release of 65.32%. The CLSM study unveiled that the developed formulation has greater permeation of MNF across the skin layers in comparison with the MNF suspension gel. The pharmacokinetic study demonstrated Cmax and AUC0-24 h of 6.94 ± 0.51 μg/ml and 43.92 ± 7.90 μg.h/ml via transdermal route in comparison to Cmax and AUC0-24 h of 3.74 ± 1.91 μg/ml and 22.96 ± 9.76 μg.h/ml presented by MNF-TE oral administration. The in vivo study revealed that the MNF-TE gel has good anti-arthritic potential in comparison with the standard diclofenac gel which was evinced by radiographic analysis and histopathological studies. Further, skin irritation study on Wistar albino rats confirm that the developed MNF-TE formulation is safer for skin application. The current investigation corroborated that the prepared TE vesicle formulation is a treasured carrier for the MNF transdermal delivery for the management of rheumatoid arthritis.
‘Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity’: in-vitro and insilico studies
Creators: name: Zakaria, Mohamed Y.
name: El-Halim, Shady M. Abd
name: Beshay, Botros Y.
name: Zaki, Islam
name: Abourehab, Mohammed A.S
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) predisposed to the emergence of worldwide catastrophe that impels the evolution of safe and effective therapeutic system. Polyphenols as resveratrol (RSV) exhibit a well evidenced antiviral activity. Unfortunately, like most phenolic nutraceuticals, RSV suffers from restrained solubility and massive degradation in GIT and liver which in turn prohibit its clinical use. Herein, PEGylated bilosomes (PBs) contain PEGylated edge activator along with the traditional components as (Span 60, cholesterol and bile salts) were proposed to boost both permeability and bioavailability of RSV. The investigation of the prominent effect of the diverse variables on the characteristics of the vesicles and picking of the optimum formula were conducted via construction of 23 factorial experiment. The appraisal of the formulae was conducted on the basis of entrapment efficiency percent (EE%), particle size (PS) and zeta potential (ZP). In addition, the spherical shaped optimal formula (F5) exhibited EE% of 86.1 ± 2.9%, PS of 228.9 ± 8.5 nm, and ZP of −39.8 ± 1.3 mV. The sorted optimum formula (F5) exhibited superior dissolution behaviors, and boosted Caco-2 cells cellular uptake by a round 4.7 folds relative to RSV dispersion. In addition, F5 demonstrated a complete in vitro suppression of SARS-CoV-2 at a concentration 0.48 μg/ml with 6.6 times enhancement in antiviral activity relative to RSV dispersion. The accomplished molecular modeling heavily provided proof for the possible interactions of resveratrol with the key residues of the SARS-CoV2 Mpro enzyme. Finally, F5 could be proposed as a promising oral panel of RSV for curation from SARS-CoV-2 infection.
M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver
Creators: name: Tan, Xiaochuan
name: Hao, Yumei
name: Ma, Nai
name: Yang, Yige
name: Jin, Wenzhen
name: Meng, Ya
name: Zhou, Chuchu
name: Zheng, Wensheng
name: Zhang, Yujia
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Virology

description: Liver fibrosis is a key pathological process shared by the progression of various chronic liver diseases. Treatment of liver fibrosis can effectively block the occurrence and development of hepatic cirrhosis or even carcinoma. Currently, there is no effective drug delivery vehicle for curing liver fibrosis. In this study, we designed matrine (MT)-loaded mannose 6-phosphate (M6P) modified human serum albumin (HSA) conjugated solid lipid nanoparticles (SLN), named M6P-HSA-MT-SLN for treatment of hepatic fibrosis. We demonstrated that M6P-HSA-MT-SLN exhibited controlled and sustained release properties and good stability over 7 days. The drug release experiments showed that M6P-HSA-MT-SLN exhibited slow and controlled drug release characteristics. In addition, M6P-HSA-MT-SLN showed a significant targeted ability to fibrotic liver. Importantly, in vivo studies indicated that M6P-HSA-MT-SLN could significantly improve histopathological morphology and inhibit the fibrotic phenotype. In addition, in vivo experiments demonstrate that M6P-HSA-MT-SLN could reduce the expression of fibrosis markers and alleviate the damage of liver structure. Hence, the M6P-HSA-MT-SLN provide a promising strategy to deliver therapeutic agents to fibrotic liver to prevent liver fibrosis.
MS effects of Pandemics
Creators: name: Submission, EJSP
Publisher: name: OSF Registries
Year: 2021
Subjects: subject: Theory and Philosophy
subject: Health Psychology
subject: Diseases
subject: Medicine and Health Sciences
subject: Social Psychology
subject: Virus Diseases
subject: Mental and Social Health
subject: Community Health
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Assessment of MS effects of pandemic of varying severity through death thoughts accessibility and death anxiety
title: Hydrothermal Synthesis of Low Layer Charge Trioctahedral Smectite
Creators: name:  Yi-Yu ,  Liu
name:  Schewe ,  Nils
name:  Thissen ,  Peter
name:  Emmerich ,  Katja
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Smectites are widely used in (geo-) technical applications and are important components of soils. A definition gap exists between the uncharged non-swellable pyrophyllite and talc (ξ = 0) and the low charged swellable clay minerals (smectites) with 0.2 ≤ ξ ≤ 0.6. Furthermore, no reliable measurement method exists for ξ < 0.2. A recent theoretical study on the hydration of smectites (Emmerich et al. 2018) based on the density functional theory (DFT) indicates the existence of stable dioctahedral 2:1 layer silicates with ξ < 0.2 and substitutions either in the tetrahedral or octahedral sheet that are swellable. Therefore, our focus is to synthesize low charged smectites. The Na2O-MgO-Al2O3-SiO2-H2O system was reacted for triocthedral smectite synthesis at 200℃, for 72 h, and with stoichiometric composition corresponding to ideal layer charge of 0.18. The XRD results showed that the synthesis of trioctahedral smectite was successful with a small particle size. Particle size will be confirmed by AFM measurements. The CEC indicates a low charge in the envisaged range. According to the principle of AAM method (Lagaly. 1981), under ideal assumptions, when the layer charge value is less than 0.2, the long-chain alkylammonium ions will only form a monolayer structure (basal spacing <17.7 Å) after being intercalated into the smectite layer, which can also be proved by measuring the d001 value of synthetic smectite. Similar results obtained through our experiments. References: Emmerich et al. (2018) The Journal of Physical Chemistry C 122, 7484−7493. Lagaly. (1981) Clay Minerals. 16, 1-21.
The even exciton series in Cu$_2$O
Creators: name: Schweiner, Frank
name: Main, Jörg
name: Wunner, Günter
name: Uihlein, Christoph
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In $\mathrm{Cu_{2}O}$ parity is a good quantum number and thus the exciton spectrum falls into two parts: The dipole-active exciton states of negative parity and odd angular momentum, which can be observed in one-photon absorption ($Γ_4^-$ symmetry) and the exciton states of positive parity and even angular momentum, which can be observed in two-photon absorption ($Γ_5^+$ symmetry). The unexpected observation of $D$ excitons in two-photon absorption and of $F$ excitons in one-photon absorption has given evidence that the dispersion properties of the $Γ_5^+$ orbital valence band is giving rise to a coupling of the yellow and green exciton series. In this paper we show that the even and odd parity exciton system can be consistently described within the same theoretical approach. However, the Hamiltonian of the even parity system needs, in comparison to the odd exciton case, modifications to account for the very small radius of the $1S$ exciton. In the presented treatment we take special care of the central-cell corrections, which comprise a reduced screening of the Coulomb potential at distances comparable to the polaron radius, the exchange interaction being responsible for the exciton splitting into ortho and para states, and the inclusion of terms in the fourth power of $p$ in the kinetic energy. Since the yellow $1S$ exciton state is coupled to all other states of positive parity, we show how the central-cell corrections affect the whole even exciton series. The close resonance of the $1S$ green exciton with states of the yellow exciton series has a strong impact on the energies and oscillator strengths of all implied states. The consistency between theory and experiment with respect to energies and oscillator strengths for the even and odd exciton system in $\mathrm{Cu_{2}O}$ is a convincing proof for the validity of the applied theory.
Application of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells
Creators: name: Xu, Xiaoyan
name: Zhou, Tianhao
name: Wei, Xudong
name: Jiang, Xuelian
name: Cao, Jiyan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Although surgery-based comprehensive therapy is becoming the main approach to treat laryngeal cancer, recurrence, metastasis, radiotherapy resistance and chemotherapy tolerance are still the main causes of death in patients. Targeted inhibition of laryngeal cancer stem cells has been considered as the consensus to cure laryngeal cancer. Our previous study has confirmed proto-oncogene Bmi-1 as a key regulator for self-renewal of laryngeal cancer stem cells. Targeted knockdown of Bmi-1 gene effectively inhibited the self-renewal and differentiation of laryngeal cancer stem cells, leading to the promoted sensitivity to chemotherapy including paclitaxel. However, due to off-target effects and quick degradation of the naked Bmi-1-RNAi small RNA oligo by nuclease in body fluids, it is urgently needed to develop a tumor-targeted delivery system with a protective shell. In this study, we designed and synthesized cRGD peptide-modified chitosan-polyethylene glycol slow-release nanoparticles (mPEG-CS-cRGD/Bmi-1RNAi-PTX) containing Bmi-1RNAi siRNA oligo and paclitaxel, which showed spherical in shape, 200 nm diameter in size, low cytotoxicity, strong DNA wrapping, resistance to nuclease degradation and high transfection efficiency to cells. Functional analysis indicated significant suppression of cell proliferation and migration and induction of apoptosis by the nanocomplex in laryngeal cancer cells in vitro. By application to the mouse model with laryngeal cancer, the nanocomplex inhibited tumor growth significantly in vivo. In addition, cRGD peptide, paclitaxel and Bmi-1 siRNA in the nanoparticles showed synergistic effects to suppress laryngeal cancer stem cells. In conclusion, this study not only developed a laryngeal tumor-targeted chemotherapeutic system, but also demonstrated a Bmi-1 RNAi-based chemotherapeutic strategy to inhibit cancer stem cells, having strong potential to treat laryngeal cancer patients suffering therapy resistance and/or tumor recurrence.
Additional file 3 of ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis
Creators: name: Zheng, Lei
name: Xu, Hongmei
name: Di, Ya
name: Chen, Lanlan
name: Liu, Jiao
name: Kang, Liying
name: Gao, Liming
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Table S3. The correlation between ELK4 mRNA expression with M1 and M2 markers.
An analytical model of crater count equilibrium
Creators: name: Hirabayashi, Masatoshi
name: Minton, David A.
name: Fassett, Caleb I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Crater count equilibrium occurs when new craters form at the same rate that old craters are erased, such that the total number of observable impacts remains constant. Despite substantial efforts to understand this process, there remain many unsolved problems. Here, we propose an analytical model that describes how a heavily cratered surface reaches a state of crater count equilibrium. The proposed model formulates three physical processes contributing to crater count equilibrium: cookie-cutting (simple, geometric overlap), ejecta-blanketing, and sandblasting (diffusive erosion). These three processes are modeled using a degradation parameter that describes the efficiency for a new crater to erase old craters. The flexibility of our newly developed model allows us to represent the processes that underlie crater count equilibrium problems. The results show that when the slope of the production function is steeper than that of the equilibrium state, the power law of the equilibrium slope is independent of that of the production function slope. We apply our model to the cratering conditions in the Sinus Medii region and at the Apollo 15 landing site on the Moon and demonstrate that a consistent degradation parameterization can successfully be determined based on the empirical results of these regions. Further developments of this model will enable us to better understand the surface evolution of airless bodies due to impact bombardment.
description: 24 pages, 9 figures, accepted for publication in Icarus
title: Collecting, sharing, and visualising harmonised data on European raw materials occurrences and mines – success or failure?
Creators: name:  Kumelj ,  Špela
name:  Jørgensen ,  Lisbeth Flindt
name:  Schjøth ,  Frands
name:  Vihtelič ,  Andrej
name:  Bahar ,  Blaž
name:  Hribernik,  Katarina
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Geological Survey of Slovenia, Slovenia(1);Geological Survey of Denmark and Greenland, Denmark(2);Easy web access to useful and reliable mineral information for the whole of Europe is the main objective of the extension of the M4EU base in the GeoERA project Mineral Intelligence for Europe (MINTELL4EU). The foundation has been laid by previous projects such as Minerals4EU, ProSUM, SCRREEN, EuRare, ORAMA, and new ones have been added in collaboration with ongoing projects such as RESEERVE. Europe's geological survey organizations play an important role as they are the main contributors in collecting and storing information on raw materials at national or regional level and making it available to end users as policy and decision makers. The information includes, among other things, the location of individual mineral deposits (occurrences) and mines, etc., which are stored in a central database, now called MIN4EU. However, national datasets are typically organized differently from country to country, based on different geological traditions and legal obligations. Our goal was to maximize harmonization, achieve higher quality of collected data, achieve higher interoperability by following the INSPIRE directive, include data from a larger number of countries, and visualize these data on the European Geological Data Infrastructure (EGDI) in a harmonized, sometimes targeted way. The methods for collecting (harvesting) data and several error detections tools to help data providers check the status of their national data reported in MIN4EU DB will be discussed. Examples of successful and less successful harmonized visualizations, data sharing with other information systems and future challenges are also presented.
Charge diffusion in the one-dimensional Hubbard model
Creators: name: Steinigeweg, R.
name: Jin, F.
name: De Raedt, H.
name: Michielsen, K.
name: Gemmer, J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the real-time and real-space dynamics of charge in the one-dimensional Hubbard model in the limit of high temperatures. To this end, we prepare pure initial states with sharply peaked density profiles and calculate the time evolution of these nonequilibrium states, by using numerical forward-propagation approaches to chains as long as 20 sites. For a class of typical states, we find excellent agreement with linear-response theory and unveil the existence of remarkably clean charge diffusion in the regime of strong particle-particle interactions. Moreover, we demonstrate that this diffusive behavior does not depend on certain details of our initial conditions, i.e., it occurs for five different realizations with random and nonrandom internal degrees of freedom, single and double occupation of the central site, and displacement of spin-up and spin-down particles.
description: 5 pages, 4 figures (+ 3 pages, 5 figures)
Additional file 4: Table S3. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-Î˛1 activation model
Creators: name: Huipeng Li
name: Venkatraman, Lakshmi
name: Balakrishnan Narmada
name: White, Jacob
name: Hanry Yu
name: Tucker-Kellogg, Lisa
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology

description: List of primer sequences for genes probed on quantitative real time PCR. (PDF 26 kb)
Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives
Creators: name: Sugimoto, Yuri
name: Suga, Tadaharu
name: Umino, Mizuki
name: Yamayoshi, Asako
name: Mukai, Hidefumi
name: Kawakami, Shigeru
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology
Computational Biology

description: Functionalized drug delivery systems have been investigated to improve the targetability and intracellular translocation of therapeutic drugs. We developed high functionality and quality lipids that met unique requirements, focusing on the quality of functional lipids for the preparation of targeted nanoparticles using microfluidic devices. While searching for a lipid with high solubility and dispersibility in solvents, which is one of the requirements, we noted that KK-(EK)4-lipid imparts nonspecific cellular association to polyethylene glycol (PEG)-modified (PEGylated) liposomes, such as cell-penetrating peptides (CPPs). We investigated whether KK-(EK)4-lipid, which has a near-neutral charge, is a novel CPP-modified lipid that enhances the intracellular translocation of nanoparticles. However, the cellular association mechanism of KK-(EK)4-lipid is unknown. Therefore, we synthesized (EK)n-lipid derivatives based on the sequence of KK-(EK)4-lipid and determined the sequence sites involved in cellular association. In addition, KK-(EK)4-lipid was applied to extracellular vesicles (EVs) and mRNA encapsulated lipid nanoparticles (mRNA-LNPs). KK-(EK)4-lipid-modified EVs and mRNA-LNPs showed higher cellular association and in vitro protein expression, respectively, compared to unmodified ones. We elucidated KK-(EK)4-lipid to have potential for applicability in the intracellular delivery of liposomes, EVs, and mRNA-LNPs.
Additional file 3: Table S2. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-Î˛1 activation model
Creators: name: Huipeng Li
name: Venkatraman, Lakshmi
name: Balakrishnan Narmada
name: White, Jacob
name: Hanry Yu
name: Tucker-Kellogg, Lisa
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Parameters settings for different models. (PDF 47 kb)
Additional file 2: Table S1. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-Î˛1 activation model
Creators: name: Huipeng Li
name: Venkatraman, Lakshmi
name: Balakrishnan Narmada
name: White, Jacob
name: Hanry Yu
name: Tucker-Kellogg, Lisa
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: List of equations and parameters used for model construction. (PDF 280 kb)
Feeding and feedback in the powerful radio galaxy 3C 120
Creators: name: Tombesi, F.
name: Mushotzky, R. F.
name: Reynolds, C. S.
name: Kallman, T.
name: Reeves, J. N.
name: Braito, V.
name: Ueda, Y.
name: Leutenegger, M. A.
name: Williams, B. J.
name: Stawarz, L.
name: Cappi, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the spectral analysis of a 200~ks observation of the broad-line radio galaxy 3C~120 performed with the high energy transmission grating (HETG) spectrometer on board the \emph{Chandra} X-ray Observatory. We find (i) a neutral absorption component intrinsic to the source with column density of $\text{log}N_H = 20.67\pm0.05$~cm$^{-2}$, (ii) no evidence for a warm absorber with an upper limit on the column density of just $\text{log}N_H < 19.7$~cm$^{-2}$ assuming the typical ionization parameter log$ξ$$\simeq$2.5~erg~s$^{-1}$~cm, the warm absorber may instead be replaced by (iii) a hot emitting gas with temperature $kT \simeq 0.7$~keV observed as soft X-ray emission from ionized Fe L-shell lines which may originate from a kpc scale shocked bubble inflated by the AGN wind or jet with a shock velocity of about 1,000~km~s$^{-1}$ determined by the emission line width, (iv) a neutral Fe K$α$ line and accompanying emission lines indicative of a Compton-thick cold reflector with low reflection fraction $R\simeq0.2$, suggesting a large opening angle of the torus, (v) a highly ionized Fe~XXV emission feature indicative of photoionized gas with ionization parameter log$ξ$$=$$3.75^{+0.27}_{-0.38}$~erg~s$^{-1}$~cm and a column density of $\text{log}N_H > 22$~cm$^{-2}$ localized within $\sim$2~pc from the X-ray source, and (vi) possible signatures for a highly ionized disk wind. Together with previous evidence for intense molecular line emission, these results indicate that 3C~120 is likely a late state merger undergoing strong AGN feedback.
description: Accepted for publication in ApJ
Additional file 1: of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-Î˛1 activation model
Creators: name: Huipeng Li
name: Venkatraman, Lakshmi
name: Balakrishnan Narmada
name: White, Jacob
name: Hanry Yu
name: Tucker-Kellogg, Lisa
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Supplementary Notes. (PDF 107 kb)
Additional file 12: of Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme
Creators: name: Li, Qi
name: Dong, Chengya
name: Cui, Jiayue
name: Wang, Yubo
name: Hong, Xinyu
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Figure S6. Knockdown of HOTAIRM1 increased H3K9me2 and H3K27me3 modifications in the promoter region of the HOXA1 gene in established and primary GBM cells. (DOCX 758 kb)
Topography of the nuclei and distribution of Acetylcholinesterase activity in the septum of the telencephalon in man
Creators: name: Bialowas, Jacek
Publisher: name: arXiv
Year: 2017
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Distribution of acetylcholinesterase (AChE) activity in the septum of the telencephalon in man was studied in 15 human brains using the acetylthiocholine method. Highest activity of AChE was found in the nucleus of the diagonal band and nucleus accumbens, and lowest in the Lateral nucleus. Comparison of histochemical results with cellular structure and wi.th the course of fibers showed absence in man of some of the nuclei described in animals such as the anterior medial nucleus, triangular nucleus, and marked reduction of the septo-hippocampal nucleus and fimbriate nucleus. Areas of the septum showing AChE activity were divided into an anterior and posterior system. The applicability to man of some neurophysiologic findings in animals is discussed.
description: 12 pages, 4 figures