cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4+ T cells - CEA research letter supplementary date
Creators: name: Arai, Hiroyuki
name: Kouzaki, Hideaki
name: Murao, Takuya
name: Nakamura, Keigo
name: Kawakita, Kento
name: Matsumoto, Koji
name: Kikuoka, Hirotaka
name: Yuta, Atsushi
name: Shimizu, Takeshi
Publisher: name: Zenodo
Year: 2022

description: Supplementary date (Methods, Tables S1-2, Figures S1-6)
Voluntary feed intake and growth performance of boars and barrows in dependence on lysine-to-energy ratio
Creators: name: Otten, Caroline
name: Berk, Andreas
name: Dänicke, Sven
Publisher: name: Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
Year: 2013
Subjects: subject: 570 Life sciences

description: Archiv Tierzucht 56 (2013) 39, 399-409; ISSN 0003-9438
Processing and recognition of document and GIS images
Creators: name: Yu, Donggang
Publisher: name: Swinburne
Year: 2024

description: In intelligent document processing system and geographical information systems (GIS), the image processing and recognition play an important role. This thesis deals with various problems in processing images in documents and GIS: image smoothing, filling, linearization and extraction of contour features, extraction of structural points, separation and recognition of spurious segments in handwritten digits, reconstruction and recognition of broken digits, and separation and recognition of colour document and GIS images. These approaches are also called Optical Character Recognition (OCR). A new smoothing technique is developed to smooth follow contours of image. With the new smoothing algorithms, spurious pixels (points) of contours are removed based on smooth patterns, and smooth followed contours are found. Also, skeletons of image can be smoothed between neighboring 'end' and 'junction' points. Smooth following makes linearization of smoothed contours possible based on Freeman codes. A new filling algorithm of contours, project filling, is described based on two kinds of structural patterns. By this method, any complicated contours of images can be filled correctly. Different from other linearization methods, linearization and feature extraction of smoothed contours are based on difference chain codes. Curvature and bend angles of linearized are found. The convexity and concavity of linearized are described. In this way, a series of description features of contours is formed. Structural points are new and useful features to describe morphological structures between neighboring linearized lines. Extraction of structural points is based on structural patterns which are determined by element chain codes. Also, extension Freeman codes are used in this thesis. Structural points make description and recognition of contours possible. In order to recognize handwritten digits in document processing systems, separation of spurious segments, reconstruction of broken digits and recognition of handwritten digits are investigated. Experiments with large number of testing data set show satisfactory results for these algorithms. Separation and recognition of colour document and GIS images are discussed. Object images of document and GIS images are extracted based on the description of shape structures, prior knowledge and color information, which are associated with each other. Color images can be described by a limited number of colors in color document and GIS images. Therefore, separation of color image is done by color reduction method, and recognition of object images is based on structure patterns, prior knowledge and colour information. It can be seen that specific information should be considered in many practical problems to achieve better processing results.
Estimation of Conditional Average Treatment Effects With High-Dimensional Data
Creators: name: Qingliang Fan
name: Hsu, Yu-Chin
name: Lieli, Robert P.
name: Yichong Zhang
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Given the unconfoundedness assumption, we propose new nonparametric estimators for the reduced dimensional conditional average treatment effect (CATE) function. In the first stage, the nuisance functions necessary for identifying CATE are estimated by machine learning methods, allowing the number of covariates to be comparable to or larger than the sample size. The second stage consists of a low-dimensional local linear regression, reducing CATE to a function of the covariate(s) of interest. We consider two variants of the estimator depending on whether the nuisance functions are estimated over the full sample or over a hold-out sample. Building on Belloni at al. and Chernozhukov et al., we derive functional limit theory for the estimators and provide an easy-to-implement procedure for uniform inference based on the multiplier bootstrap. The empirical application revisits the effect of maternal smoking on a baby’s birth weight as a function of the mother’s age.
Estimation of Conditional Average Treatment Effects with High-Dimensional Data
Creators: name: Qingliang Fan
name: Hsu, Yu-Chin
name: Lieli, Robert P.
name: Yichong Zhang
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Given the unconfoundedness assumption, we propose new nonparametric estimators for the reduced dimensional conditional average treatment effect (CATE) function. In the first stage, the nuisance functions necessary for identifying CATE are estimated by machine learning methods, allowing the number of covariates to be comparable to or larger than the sample size. The second stage consists of a low-dimensional local linear regression, reducing CATE to a function of the covariate(s) of interest. We consider two variants of the estimator depending on whether the nuisance functions are estimated over the full sample or over a hold-out sample. Building on Belloni at al. (2017) and Chernozhukov et al. (2018), we derive functional limit theory for the estimators and provide an easy-to-implement procedure for uniform inference based on the multiplier bootstrap. The empirical application revisits the effect of maternal smoking on a baby’s birth weight as a function of the mother’s age.
Addressing user needs in single-cell analysis; internship and obstacles
Creators: name: Howells, Morgan
name: Poterlowicz, Krzysztof
name: Jakiela, Julia
name: Bacon, Wendi
Publisher: name: F1000 Research Limited
Year: 2024

description: Galaxy is an indispensable resource for biologists, offering an accessible platform for bioinformatics knowledge, research, and analysis. Despite this, numerous user needs in the single cell community are yet unaddressed. First, manual cell annotation is difficult, time-consuming, and produces subjective results. Second, users struggle to ingest, understand, or reformat data, from a milieu of wildly different data types. How do we address these key user needs?



This talk will cover the contributions and insights gained from a 10-week internship and resultant further opportunities working with Galaxy – as a computer scientist stepping to the world of biology.



First, a workflow and tutorial were built to perform automatic cell annotation using existing tools and single cell references. Users are now able to speed up this important step in analysing their single-cell data whilst enabling their work to be reproducible.



Second, the NCBI is a large repository of biotechnical information including numerous single cell datasets. Users frequently requested a bridge between this vast repository of data and the Galaxy

platform. A tutorial was developed to teach users how to import data from the NCBI and – critically – to convert it into the common AnnData format – From here, users can leverage the growing library of single-cell tutorials to further manipulate and analyse their data.



Coming into this project from a computer science background with little foundational biology knowledge, the Galaxy Training Network served as an indispensable resource in understanding the basics of single cell analysis and the Galaxy platform. Additionally, the vast array of tools and environments available in Galaxy facilitated the development of tutorials that allows users to customise their analysis.



During the development of these resources, various challenges were encountered. The development of the cell annotation tutorial revealed that the integrated cell annotation tools were broken in various ways. The process of resolving these issues is slow and cumbersome. The various channels of communication and a lack of documentation presents a barrier to many users and developers.



This initial venture into Galaxy revealed its robustness and educational value which were instrumental for integrating into bioinformatics. The obstacles encountered highlight opportunities for improvement to foster a more inclusive and supportive environment for developers and technically includes users, ultimately strengthening the platform’s role in the bioinformatics community.
Dynamical evolution of globular cluster systems in clusters of galaxies: the case of NGC 1404 in the Fornax Cluster
Creators: name: Bekki, Kenji
name: Couch, Warrick
name: Forbes, Duncan
name: Beasley, Michael
Publisher: name: Swinburne
Year: 2024

description: We investigate, via numerical simulations, the tidal stripping and accretion of globular clusters (GCs). In particular, we focus on creating models that simulate the situation for the GC systems of KGC 1404 and NGC 1399 in the Fornax cluster, which have poor (specific frequency SN~2) and rich (SN~10) GC systems respectively. vVe initially assign NGC 1404 in our simulation a typical SN (~5) for cluster ellipticals, and find that its GC system can only be reduced through stripping to the presently observed value, if its orbit is highly eccentric ( with orbital eccentricity of> 0.5) and if the initial scale length of the GCs system is about twice as large as the effective radius of NGC 1404 itself. These stripped GCs can be said to have formed a 'tidal stream' of intra-cluster globular clusters (ICGCs) orbiting the center of Fornax cluster (many of which would be assigned to NGC 1399 in an imaging study). The physical properties of these GCs (e.g., number, radial distribution, and kinematics) depend on the orbit and initial distribution of GCs in NGC 1404. Our simulations also predict a trend for SN to rise with increasing cluster-centric distance - a trend for which there is some observational support in the Fornax cluster. We demonstrate that since the kinematical properties of ICGCs formed by tidal stripping in the cluster tidal field depend strongly on the orbits of their previous host galaxies, observations of ICGC kinematics provides a new method for probing galaxy dynamics in a cluster.
Identifying conserved trajectories in clonal evolution trees
Creators: name: Sandmann, Sarah
name: Randau, Gerrit
name: Vrugt, Marcel Te
name: Beder, Thomas
name: Neumann, Martin
name: Brüggemann, Monika
name: Burkhardt, Birgit
name: Varghese, Julian
Publisher: name: F1000 Research Limited
Year: 2024

description: The analysis of clonal evolution allows to reconstruct tumor development over time, explore treatment response, and identify potential reasons for therapy failure. This allows for an in-depth analysis of a patient’s heterogeneous tumor cell composition. Furthermore, phylogenetic trees hold the promise of revealing common patterns conserved across different patients.

Several approaches exist, e.g. MASTRO or TreeMHN. However, these focus exclusively on mutated genes, neglecting copy number variants (CNVs). Additionally, TreeMHN requires mutations to be acquired successively. While MASTRO supports mutations of unknown order, the resulting high number of possible relations hinders the analysis of more complex phylogenetic trees due to substantial storage requirements.

We propose a novel approach for identifying conserved trajectories in clonal evolution trees: exact SNVs and indels are reduced to the gene they affect. CNVs are transformed to their smallest possible representation, e.g. del9 becomes del_in_9p and del_in_9q, to identify common elements of different CNVs affecting chromosome 9. For each patient, all observed patterns of 2 and 3 levels are determined, and their probabilities are calculated using Laplace-distribution. The total number of possible patterns is defined as n!/(n-k)! (n unique mutations, k levels). The number of observed patterns is considered the number of trials. The occurrence of each pattern across all patients is counted. Statistical significance is determined assuming Poisson binomial distribution.

The analysis of 149 patients with T-ALL or T-LBL demonstrates the applicability of our new method even to cases of hypermutation. Common mutational patterns are successfully identified, including both SNVs/indels as well as CNVs.
Intermittent feeding program and addition of Bacillus subtilis based probiotics to the diet of growing broiler chickens: Influence on growth, hepatic enzymes and serum lipid metabolites profile
Creators: name: Aliakbarpour, Hamid Reza
name: Chamani, Mohammad
name: Rahimi, Godrat
name: Sadeghi, Ali Asghar
name: Qujeq, Durdi
Publisher: name: Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
Year: 2013
Subjects: subject: 570 Life sciences

description: Archiv Tierzucht 56 (2013) 40, 410-422; ISSN 0003-9438
Fortentwicklung der Abgasuntersuchung
Creators: name: Schneider, Frank
name: Hahn, Harald
name: Schulz, Wolfgang H.
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Abgasuntersuchung
subject: Abgasmessung
subject: Trübungsgrad
subject: CO2-Abgasgrenzwert
subject: Stickstoffoxid-Emissionen
subject: Dieselmotor
subject: Luftschadstoff
subject: Luft
subject: Verkehr

description: Das Umweltbundesamt hat in einem Forschungsprojekt untersuchen lassen, welche Messverfahren für Diesel-Pkw geeignet sind, um defekte Bauteile und Systeme zur Minderung von Stickstoffoxid-Emissionen (NOx) im Rahmen der regelmäßig durchzuführenden Abgasuntersuchung (AU) zu erkennen. Zentrales Ergebnis ist, dass die Ergänzung der AU um den Luftschadstoff NOx für Diesel-Pkw und leichte Nutzfahrzeuge mit Dieselmotor mit den betrachteten Prüf- und Testmethoden messtechnisch leistbar und gesamtwirtschaftlich sinnvoll ist. In einem nächsten Schritt sollten auf Basis dieser Empfehlungen ein konkreter Zeitplan für die Umsetzung erarbeitet und die dafür notwendigen Meilensteine festgelegt werden.
Genetic and phenotypic parameters for productive traits in the first three lactations of Khuzestan buffaloes in Iran
Creators: name: Madad, Mostafa
name: Ghavi Hossein-Zadeh, Navid
name: Shadparvar, Abdol Ahad
Publisher: name: Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany
Year: 2013
Subjects: subject: 570 Life sciences

description: Archiv Tierzucht 56 (2013) 41, 423-429; ISSN 0003-9438
NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Creators: name: Tsesmelis, Miltiadis
name: Büttner, Ulrike F. G.
name: Gerstenlauer, Melanie
name: Manfras, Uta
name: Tsesmelis, Konstantinos
name: Du, Ziwei
name: Sperb, Nadine
name: Weissinger, Stephanie Ellen
name: Möller, Peter
name: Barth, Thomas F. E.
name: Maier, Harald J.
name: Chan, Lap Kwan
name: Wirth, Thomas
Publisher: name: Universität Ulm
Year: 2024
Subjects: subject: PDAC
subject: PanINs
subject: NEMO
subject: NF-κB
subject: Senescence
subject: Cerulein
subject: Pancreatitis
subject: DDC 610 / Medicine & health

description: Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is marked by a dismal survival rate, lacking effective therapeutics due to its aggressive growth, late-stage diagnosis, and chemotherapy resistance. Despite debates on NF-κB targeting for PDAC treatment, no successful approach has emerged. Methods To elucidate the role of NF-κB, we ablated NF-κB essential modulator (NEMO), critical for conventional NF-κB signaling, in the pancreata of mice that develop precancerous lesions (KC mouse model). Secretagogue-induced pancreatitis by cerulein injections was utilized to promote inflammation and accelerate PDAC development. Results NEMO deletion reduced fibrosis and inflammation in young KC mice, resulting in fewer pancreatic intraepithelial neoplasias (PanINs) at later stages. Paradoxically, however, NEMO deletion accelerated the progression of these fewer PanINs to PDAC and reduced median lifespan. Further, analysis of tissue microarrays from human PDAC sections highlighted the correlation between reduced NEMO expression in neoplastic cells and poorer prognosis, supporting our observation in mice. Mechanistically, NEMO deletion impeded oncogene-induced senescence (OIS), which is normally active in low-grade PanINs. This blockage resulted in fewer senescence-associated secretory phenotype (SASP) factors, reducing inflammation. However, blocked OIS fostered replication stress and DNA damage accumulation which accelerated PanIN progression to PDAC. Finally, treatment with the DNA damage-inducing reagent etoposide resulted in elevated cell death in NEMO-ablated PDAC cells compared to their NEMO-competent counterparts, indicative of a synthetic lethality paradigm. Conclusions NEMO exhibited both oncogenic and tumor-suppressive properties during PDAC development. Caution is suggested in therapeutic interventions targeting NF-κB, which may be detrimental during PanIN progression but beneficial post-PDAC development. Graphical Abstract
Formal Specification and Verification of Hyperledger Fabric Chaincode
Creators: name: Beckert, Bernhard
name: Herda, Mihai
name: Kirsten, Michael
name: Schiffl, Jonas
Publisher: name: Institute for Integrated and Intelligent Systems
Year: 2018
Subjects: formal program verification
blockchain
smart contract
Hyperledger Fabric

description: Smart contracts are programs building on blockchain technology. They implement functionality that has been agreed on between the concerned parties on a network. However, their immutability and exposed position make them vulnerable to programming errors, leading to faulty behavior and possible exploits. Therefore, smart contracts demand a particularly thorough analysis, ideally using formal program verification. In this paper, we present an approach for the deductive verification of Hyperledger Fabric smart contracts using the KeY prover. We have extended KeY to handle Fabric ledger implementations; in particular, we have developed mechanisms for reasoning about serialization and object persistence. The feasibility of our approach is demonstrated with a small case study.
title: Quasi-homogenous photocatalysis of quantum-sized Fe-doped TiO₂ in optically transparent aqueous dispersions
Creators: name: Einert, Marcus
name: Hartmann, Pascal
name: Smarsly, Bernd
name: Brezesinski, Torsten
Publisher: name: Springer Nature
Year: 2022

description: In this study, the preparation of anatase TiO₂ nanocrystals via a facile non-aqueous sol–gel route and their characterization are reported. The 3–4 nm particles are readily dispersable in aqueous media and show excellent photoreactivity in terms of rhodamine B degradation. The catalytic performance can be further increased considerably by doping with iron and UV-light irradiation as a pre-treatment. The effect of surface ligands (blocked adsorption sites, surface defects etc.) on the photoreactivity was thoroughly probed using thermogravimetric analysis combined with mass spectrometry. Photoelectrochemical characterization of thin-film electrodes made from the same TiO₂ nanocrystals showed the opposite trend to the catalytic experiments, that is, a strong decrease in photocurrent and quantum efficiency upon doping due to introduction of shallow defect states.
title: Unsupervised Clustering Pipeline to Obtain Diversified Light Spectra for Subject Studies and Correlation Analyses
Creators: name: Klir, Stefan
name: Fathia, Reda
name: Babilon, Sebastian
name: Benkner, Simon
name: Khanh, Tran Quoc
Publisher: name: MDPI
Year: 2022

description: Featured Application: Selection of most diverse light spectra from a larger set of possible candidates to be used in subject studies or for machine learning to find correlations between photometric and other parameters such as psychological, physiological, or preference-based outcome measures. Abstract: Current subject studies and data-driven approaches in lighting research often use manually selected light spectra, which usually exhibit a large bias due to the applied selection criteria. This paper, therefore, presents a novel approach to minimize this bias by using a data-driven framework for selecting the most diverse candidates from a given larger set of possible light spectra. The spectral information per wavelength is first reduced by applying a convolutional autoencoder. The relevant features are then selected based on Laplacian Scores and transformed to a two-dimensional embedded space for subsequent clustering. The low dimensional embedding, from which the required diversity follows, is done with respect to the locality of the features. In a second step, photometric parameters are considered and a second clustering is performed. As a result of this algorithmic pipeline, the most diverse selection of light spectra complying with a given set of relevant photometric parameters can be extracted and used for further experiments or applications.
title: Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation
Creators: name: Nehls, Thomas
name: Heymann, Tim
name: Meyners, Christian
name: Hausch, Felix
name: Lermyte, Frederik
Publisher: name: MDPI
Year: 2022

description: In order to understand protein structure to a sufficient extent for, e.g., drug discovery, no single technique can provide satisfactory information on both the lowest-energy conformation and on dynamic changes over time (the ‘four-dimensional’ protein structure). Instead, a combination of complementary techniques is required. Mass spectrometry methods have shown promise in addressing protein dynamics, but often rely on the use of high-end commercial or custom instruments. Here, we apply well-established chemistry to conformation-sensitive oxidative protein labelling on a timescale of a few seconds, followed by analysis through a routine protein analysis workflow. For a set of model proteins, we show that site selectivity of labelling can indeed be rationalised in terms of known structural information, and that conformational changes induced by ligand binding are reflected in the modification pattern. In addition to conventional bottom-up analysis, further insights are obtained from intact mass measurement and native mass spectrometry. We believe that this method will provide a valuable and robust addition to the ‘toolbox’ of mass spectrometry researchers studying higher-order protein structure.
Polarity during migration and asymmetric cell division in fate determination of thymocytes
Creators: name: Pham, Kim
Publisher: name: Swinburne
Year: 2024

description: The thymus is the site that generates many of the T cell subsets for our adaptive immunity. The T cells that mediate immune responses are generated in the thymus from thymocytes. Elucidating the mechanisms for thymocyte fate determination has the potential for profound impact upon autoimmunity, vaccination, recovery from immunosuppression during chemotherapy and leukemogenesis. In solid tissues, fate determination is dictated by asymmetric cell division (ACD). ACD involves the induction and maintenance of polarity during division, resulting in two daughter cells with different molecular composition and fates. Recently, studies have shown that the fate of hematopoietic stem cells and T cells are influenced by ACD, and that the mechanisms of polarity are conserved. It is unknown whether ACD occurs in thymocytes to determine fate outcome. In this thesis I investigated whether ACD occurs in DN3 thymocytes. Using an in vitro system of T cell development, I established protocols for time lapse imaging of thymocytes, and co-developed a software platform to quantify polarisation in migrating and dividing DN3 thymocytes. A number of proteins previously implicated in ACD polarise in DN3 thymocytes, and excitingly, two of these, Numb and Ap2a2, polarise in DN3 thymocytes during division. These experiments provide the first quantified evidence that DN3 thymocytes undergo ACD. To investigate the molecular mechanisms and consequences of DN3 ACD, I used several in vitro approaches and a mouse model of T cell leukaemia driven by overexpression of Lmo2. Abrogation of Numb phosphorylation by the polarity protein aPKC prevents Numb polarisation during DN3 division, but not during migration. Disruption of chemokine signalling reduces Ap2a2 polarisation, providing a mechanism through which ACD may be controlled. Using Ap2a2 polarisation as a marker for ACD, I demonstrate that the altered fate of leukaemic DN3 thymocytes is associated with a reduction in ACD. Combinatorial effects of Lmo2 overexpression, inhibition of chemokine signalling and Ap2a2 overexpression correlate with effects on polarity and differentiation of DN3 thymocytes, suggesting that ACD of DN3 thymocytes impacts upon DN3 fate decisions. These results indicate for the first time that thymocytes undergo ACD, and suggest a novel molecular mechanism for control of fate in thymocytes. Furthermore, they suggest that disruption of ACD is associated with development of leukemia. My preliminary evidence, together with the technological platform that I developed provide a foundation for future experiments to investigate the impact of ACD with thymocyte fate outcome in normal development and leukaemogenesis.
title: On the Intergranular Corrosion Properties of Thin Ferritic Stainless Steel Sheets Welded by Fiber-Laser
Creators: name: Sommer, Niklas
name: Kryukov, Igor
name: Wolf, Christian
name: Wiegand, Michael
name: Kahlmeyer, Martin
name: Böhm, Stefan
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: intergranular corrosion
subject: ferritic stainless steel
subject: laser welding
subject: microstructure
subject: mechanical properties
subject: stabilization
subject: fiber-laser
subject: thin sheets
subject: butt joint
subject: 600
subject: Interkristalline Korrosion
subject: Ferritischer Stahl
subject: Laserschweißen
subject: Mikrostruktur
subject: Mechanische Eigenschaft
subject: Stabilisierung
subject: Faserlaser
subject: Feinblech
subject: Stumpfstoß

description: Gefördert durch den Publikationsfonds der Universität Kassel
title: Leitfaden 2020 für Deutschland mit vielen Praxisbeispielen
title: Leitfaden 2020 für Deutschland mit vielen Praxisbeispielen
titleType: AlternativeTitle
Creators: name: Kiso, Claudia
name: Zarske, Maja
Publisher: name: Umweltbundesamt
Year: 2020

description: Die EUROPÄISCHE MOBILITÄTSWOCHE (kurz EMW) ist eine Kampagne der Europäischen Kommission. Jedes Jahr vom 16. bis 22. September bietet sie Kommunen aus ganz Europa die perfekte Möglichkeit, ihren Bürgerinnen und Bürgern die komplette Bandbreite nachhaltiger Mobilität vor Ort näher zu bringen. Der neue EMW-Leitfaden 2020 für Deutschland fasst auf 34 Seiten alle wichtigen Informationen rund um die EMW zusammen und bietet außerdem durch 16 neue Praxisbeispiele aus Deutschland und dem europäischen Ausland Inspirationen für die eigene Teilnahme. Quelle: Umweltbundesamt
title: Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation
Creators: name: Langer, Kai
name: Müller-Längle, Adriana
name: Wempe, Jannik
name: Laube, Bodo
Publisher: name: Frontiers Media
Year: 2022

description: Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial role in excitatory synaptic transmission in the central nervous system. Each subunit contributes with three helical transmembrane segments (M1, M3, and M4) and a pore loop (M2) to form the channel pore. Recent studies suggest that the architecture of all eukaryotic iGluRs derives from a common prokaryotic ancestral receptor that lacks M4 and consists only of transmembrane segments M1 and M3. Although significant contribution has emerged in the last years, the role of this additionally evolved transmembrane segment in iGluR assembly and function remains unclear. Here, we have investigated how deletions and mutations of M4 in members of the NMDA receptor (NMDAR) subfamily, the conventional heteromeric GluN1/GluN2 and glycine-gated GluN1/GluN3 NMDARs, affect expression and function in Xenopus oocytes. We show that deletion of M4 in the GluN1, GluN2A, or GluN3A subunit, despite retained receptor assembly and cell surface expression, results in nonfunctional membrane receptors. Coexpression of the corresponding M4 as an isolated peptide in M4-deleted receptors rescued receptor function of GluN1/GluN2A NMDARs without altering the apparent affinity of glutamate or glycine. Electrophysiological analyses of agonist-induced receptor function and its modulation by the neurosteroid pregnenolone sulfate (PS) at mutations of the GluN1-M4/GluN2/3-transmembrane interfaces indicate a crucial role of position M813 in M4 of GluN1 for functional coupling to the core receptor and the negative modulatory effects of PS. Substitution of residues and insertion of interhelical disulfide bridges confirmed interhelical interactions of positions in M4 of GluN1 with residues of transmembrane segments of neighboring subunits. Our results show that although M4s in NMDARs are not important for receptor assembly and surface expression, the residues at the subunit interface are substantially involved in M4 recognition of the core receptor and regulation of PS efficacy. Because mutations in the M4 of GluN1 specifically resulted in loss of PS-induced inhibition of GluN1/GluN2A and GluN1/GluN3A NMDAR currents, our results point to distinct roles of M4s in NMDAR modulation and highlight the importance of the evolutionarily newly evolved M4 for selective in vivo modulation of glutamate- and glycine-activated NMDARs by steroids.
BIMBO-SEMINAR REPORT.docx
Creators: name: ADENUGA, ISRAEL
Publisher: name: figshare
Year: 2022
Subjects: subject: 190303 Technical Writing
subject: FOS: Media and communications
subject: 130108 Technical, Further and Workplace Education
subject: FOS: Educational sciences

description: Blockchains and cryptographic forms of money are presently subjects of generous effect that scholarly community, experts and the IT business need to examine, study, research, distribute, improve, take advantage of and embrace. This report named CRYPTOCURRENCY AND BLOCK CHAIN TECHNOLOGY expects to give data on the imaginative, insightful and proficient examination relating to the administration, association and innovative utilization of blockchains and digital currencies. The parts in this report will be fundamental for anybody keen on these spaces. This report is one of a handful of the committed altogether to blockchain innovations, applications and digital currencies.
Injury patterns and circumstances associated with electric scooter collisions : a scoping review
Creators: name: Toofany, Manish
name: Mohsenian, Sasha
name: Shum, Leona K.
name: Chan, Herbert
name: Brubacher, Jeffrey
Publisher: name: BMJ Journals
Year: 2022

description: Background Electric scooters are personal mobility devices that have risen in popularity worldwide since 2017. Emerging reports suggest that both riders and other road users, such as pedestrians and cyclists, have been injured in electric scooter-associated incidents. We undertook a scoping review of the current literature to evaluate the injury patterns and circumstances of electric scooter-associated injuries. Methods A scoping review of literature published from 2010 to 2020 was undertaken following accepted guidelines. Relevant articles were identified in Medline, Embase, SafetyLit and Transport Research International Documentation using terms related to electric scooters, injuries and incident circumstances. Supplemental searches were conducted to identify relevant grey literature (non-peer-reviewed reports). Results Twenty-eight peer-reviewed studies and nine grey literature records were included in the review. The current literature surrounding electric scooterassociated injuries mainly comprises retrospective case series reporting clinical variables. Factors relating to injury circumstances are inconsistently reported. Findings suggest that the head, upper extremities and lower extremities are particularly vulnerable in electric scooter falls or collisions, while injuries to the chest and abdomen are less common. Injury severity was inconsistently reported, but most reported injuries were minor. Low rates of helmet use among electric scooter users were noted in several studies. Conclusion Electric scooters leave riders vulnerable to traumatic injuries of varying severity. Future work should prospectively collect standardised data that include information on the context of the injury event and key clinical variables. Research on interventions to prevent electric scooter injuries is also needed to address this growing area of concern.
Comparative assessment of essential oil composition and yield in Cinnamomum tamala leaves upon application of different drying practices
Creators: name: Saha, Sulagna
name: Bhattacharya, Raktim
name: Dey, Pritam Kumar
name: Mitra, Adinpunya
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Cinnamomum tamala or Indian bay leaf is a widely used spice in the Asian subcontinent. The aim of this study was to assess the contents and composition of essential oils and volatiles internal pool in C. tamala leaves obtained from different drying practices such as, sun drying, freeze drying, shade drying and simultaneous oven drying at 60°C and 40°C, when compared with market-available dry leaves. Out of five different practices tested, leaves when oven dried at 60°C performed best in terms of free-radical scavenging capacities, internal pool of volatile contents (257.25 ± 37.57 μg/g of dried leaf tissue) and yields of essential oils (0.25%). This was followed by freeze-dried leaves, which showed 0.2% essential oils yield. Among the natural drying, sun dried leaves exhibited high yield of essential oils (0.16%). Performance of shade dried leaves was shown to be lowest i.e. 0.11% essential oils yield but was comparable with the yield of market-available leaves.
Bioassay-guided isolation and identification of antibacterial compounds from Piper betle leaf with inhibitory activity against the Vibrio species in shrimp
Creators: name: Ghosh, Alokesh Kumar
name: Panda, Sujogya Kumar
name: Hu, Haibo
name: Schoofs, Liliane
name: Luyten, Walter
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The present study examined the antimicrobial effects of betel leaf (Piper betle) extracts against Vibrio spp. along with the isolation of the most prevalent bioactive components using a bioassay-guided purification. Following a preliminary screening, the ethanolic extract proved the most effective and performed to silica gel chromatography, followed by reversed phase HPLC to isolate the active components. By means of subsequent UHPLC-orbitrap-ion trap mass spectrometry, two compounds were identified as (E)-3-phenylprop-2-enoic acid (cinnamic acid) and [4-(1-hydroxyprop-2-enyl)phenyl] acetate (1’−hydroxychavicol acetate). The compounds showed anti-microbial activity against Vibrio species including V. parahaemolyticus, V. harveyi, V. alginolyticus, V. vulnificus and V. anguillarum. Their antibacterial action was quantified by a microdilution assay showing that cinnamic acid displays more potent activity (IC50, 21–121 µg/mL) compared to 1’-hydroxychavicol acetate (IC50, 24–365 µg/mL). These findings propose the potential use of the betel leaf as a substitute for antibiotics to combat Vibrio infections in shrimp aquaculture.
Trapping of ultracold atoms in a magnetic lattice
Creators: name: Jose, Smitha
Publisher: name: Swinburne
Year: 2024

description: This dissertation presents the realization of a periodic array of Bose-Einstein condensates in a magnetic lattice consisting of an array of magnetic microtraps. Bose-Einstein condensation occurs when atoms confined in the magnetic microtraps are cooled to sufficiently low temperature that they all occupy the lowest quantum state of the traps. Evidence for the onset of Bose-Einstein condensation in multiple sites of the magnetic lattice is provided by radiofrequency spectroscopy. The realization of a periodic array of Bose-Einstein condensates in a magnetic lattice represents a major step towards the implementation of magnetic lattices to simulate exotic phenomena in lattices of complex geometry in materials science.
title: Light emission of radioactively doped crystals
Creators: name: Rudischer, Lukas
Publisher: name: TU Wien
Year: 2022
Subjects: subject: nuclear clock
subject: crystal doping

description: Th-229 has the lowest known first nuclear exited state, which makes it an ideal candidate for a prospective nuclear optical clock. Until now energy and lifetime of this isomer state are known with insufficient accuracy. For a direct (photonic) measurement of this state background effects are not neglectable. This thesis discusses light emissions occurring as background in different approaches of direct isomer energy measurements.
O'ZBEK TILI LEKSIKASINING BOYISH MANBASI BO'LGAN NEOLOGIZMLAR VA UNING TURLARI
Creators: name: Xudoynazarova, Nasibaxon
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqoladan ko’zlangan maqsad o’zbek tili leksikasining boyish manbasi bo’lgan neologizmlar va uning turlari haqida gap boradi.Bir qancha tilshunosh olimlarimiz tomonidan leksikologiyani tadbiq etish borasida bir qancha vazifalar belgilangan bo’lib, keying vazifa o’zbek tilining sistemaviy lug’atini tuzish etib belgilandi.Maqolada o’rganish obyekti etib o’zbek tili leksikasidagi o’zlashma so’zlar- neologizmlar olindi. Materiallar ,asosan ,eski va yangi nashrdagi “O’zbek tilining izohli lug’ati” dan hamda bir qancha lug’atlardan to’plandi.Ishga nazariy manba sifatida tilshunosligimizda bajarilgan monografiya va ilmiy maqolalardan foydalanildi.
Weiterentwicklung der integrierten Stickstoff-Bilanzierung als Grundlage für landwirtschaftliche Minderungsstrategien zur Unterstützung der deutschen Nachhaltigkeitsstrategie
Creators: name: Vandré, Robert
name: Häußermann, Uwe
name: Grebe, Sven
Publisher: name: My University
Year: 2016
Subjects: subject: Minderungspotenzial
subject: Ammoniumnitrat
subject: Treibhausgasemission
subject: Landwirtschaft
subject: Freisetzung von Treibhausgasen
subject: Minderungsmöglichkeit
subject: Stoffflussmodell
subject: Landwirtschaft
subject: Soil | Land

description: Die Landwirtschaft trägt zu den Emissionen klimawirksamer Gase und anderer Umwelt belastender Stickstoff-Komponenten, vor allem Ammoniak und Nitrat, bei. Um den Einfluss der Bewirtschaftung auf die Emissionen zu beurteilen, wurden vorhandene Modellansätze zur Abbildung von Stoffflüssen in landwirtschaftlichen Betrieben kombiniert und erweitert. Basierend auf Datenerhebungen auf landwirtschaftlichen Betrieben wurden Betriebsmodelle für den Marktfruchtanbau und die Milcherzeugung definiert, die ein großes Spektrum an produktionstechnischen und standörtlichen Kenngrößen aufweisen. Szenarien wurden berechnet, um den Effekt von Minderungsmaßnahmen innerhalb der Betriebe abschätzen zu können.
Strengthening policy response to protracted displacement - TRAFIG Policy Handbook
Creators: name: Wagner, Martin
name: Katsiaficas, Caitlin
name: Fogli, Camilla
Publisher: name: Zenodo
Year: 2022
Subjects: protracted displacement
durable solutions
policy recommendations
refugee protection
social networks
refugees
IDPs
internal displacement
humanitarian aid
development
participation
asylum
migration
host communities
mobility
livelihoods
entrepreneurship
Ethiopia
Jordan
Tanzania
Pakistan
Greece
Italy
Germany
DR Congo

description: Displacement is undoubtedly one of the greatest challenges facing the world today. At the end of 2020, more than 82 million people across the globe were categorised as forcibly displaced, whether remaining within their countries of origin or having crossed an international border. If this group were a country, it would rank 20th in the world in terms of population, right after Germany. An increasing number of refugees – 16 million in 2020, or 4 million more than in 2016 – find themselves in a long-term situation of vulnerability, dependency, and legal insecurity, lacking, or actively denied, opportunities to rebuild their lives. Such situations are termed ‘protracted displacement’. While not captured in these statistics, internally displaced persons (IDPs) may also find themselves in situations of protracted displacement. While the protracted nature of many conflicts is a critical contributing factor, there is considerable room for improvement in policies and practices to more effectively address protracted displacement. This is where the EU-funded Transnational Figurations of Displacement (TRAFIG) research project has aimed to contribute. Undertaking more than 2,700 interviews with displaced persons, policymakers, and practitioners in 11 countries across the Middle East, East Africa, and Europe, the TRAFIG project investigated the reasons why people end up in protracted displacement situations and what coping strategies they use, thus identifying possible courses of action for policymakers. This handbook shares 10 takeaways for strengthening policy responses to protracted displacement that have emerged from this endeavour, with empirical examples and policy recommendations, as well as a non-exhaustive list of promising practices for inspiration. These 10 points centre on the TRAFIG project goal of identifying solutions that are better tailored to the needs and capacities of displaced persons.
description: TRAFIG Policy Handbook
User-Conditional Content Decryption and Playback Control System: A Realistic Digital Rights Protection Mechanism in the Age of Deepfake
Creators: name: LEE, SI WOO
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Digital Technology/standards

description: This study proposes a novel system enabling users to embed playback conditions directly into digital content files such as video, image, or audio. These embedded conditions (e.g., device ID, expiration, online status, legal responsibility) ensure that content can only be decrypted or played when predefined rules are satisfied. It is especially applicable to AI-generated or deepfake content, helping to enforce ethical use and traceability.This paper expands on philosophical and technical foundations from a prior quantum-resistant security framework (Zenodo DOI: 10.5281/zenodo.15335044) and adapts those principles to the digital media domain.The work was ideated and completed within 5 hours using ChatGPT (OpenAI) as an AI writing assistant. All core concepts and structural logic were designed by the author, SI WOO LEE.
Precision Bragg spectroscopy of the density and spin response of a strongly interacting Fermi gas
Creators: name: Hoinka, Sascha
Publisher: name: Swinburne
Year: 2024

description: Gases of neutral atoms cooled to nanoKelvin temperatures exhibit remarkable behaviour such as superfluidity in which particles can flow indefinitely with zero friction. Superfluids made of fermionic particles are especially interesting as they occur in a variety of settings from neutron stars to superconductors; however, many of their physical properties are difficult to predict theoretically. This thesis presents experimental measurements of the universal contact parameter for a Fermi gas with strong interactions which characterizes the many-body properties of the system and secondly the spin susceptibility which describes how the system responds to magnetic fields. These results further our understandings of strongly interacting quantum systems.
title: فروسية الشيخ زايد بن سلطان آل نهيان/ عادل محمد العمودي.
Creators: name: العمودي، عادل محمد
Publisher: name: الأرشيف والمكتبة الوطنية
Year: 2023
Subjects: الفروسية - الإمارات العربية المتحدة - تاريخ
الخيل العربية - الإمارت العربية المتحدة - تراث

تعتبر رياضة الفروسية -ممثلة بركوب الخيل- إحدى هوايات الشيخ زايد بن سلطان آل نهيان مؤسس دولة الإمارت العربية المتحدة -طيب الله ثراه- إذ ارتبط بها منذ الصغر. وكان لوجود اسطيلات الخيل في الجاهلي، والمويجعي، ومِزْيدّ في مدينة العين أكبر الاثر في تعلّمه فنون هذه الرياضة، وتنمية مهاراته، وصقل مواهبة، وزيادة محبته للخيل وإكرامها. ولشدة شغفه بالخيل وعشقه لها ولِسباقاتها بنى -رحمه الله- إستطبلاته المتعددة، من فترة الستينات إلى الثمانينات، منتقيًا أجود سلالات الخيل العربية الأصيلة، ومربيًا ومنتجًا لها، وداعيًا للمحافضة عليها من الانقراض، وداعمًا لتربيتها والاهتمام بها.
N-K Model and Earth Pulse
Creators: name: Malik, Muhammad Usman
Publisher: name: Zenodo
Year: 2025

description: Description:

 

This research paper presents a groundbreaking analysis of Earth's 26-second pulse through the lens of the Noor-Kun (N-K) Model. By modeling the Earth as a resonant spherical oscillator, the study derives its fundamental frequency using two core parameters: N (structural constant) and K (field coupling constant), inspired by metaphysical foundations and Rosetta Stone constants. The results match the empirically observed ultra-low-frequency (ULF) wave of ~0.0385 Hz, known for its planetary and biological influence.

 

The paper explores the geophysical consequences of subtle frequency shifts, including tectonic stress accumulation, magnetic pole drift, and atmospheric instability. It also proposes that these oscillations may interact with biological systems, affecting animal behavior and human health. The model's precision opens new pathways to understanding Earth's deep internal processes and their synchronization with cosmic and energetic frameworks.

 

This work advances the Noor-Kun Model as a tool for planetary diagnostics, universal resonance theory, and the interface between physical and metaphysical do

mains.
Dynamical Gibbs variational principles for irreversible interacting particle systems with applications to attractor properties
Creators: name: Jahnel, Benedikt
name: Köppl, Jonas
Publisher: name: Weierstrass Institute
Year: 2022
Subjects: subject: Gibbs measures
subject: interacting Markov jump processes
subject: Gibbs variational principle
subject: time-reversed dynamics
subject: relative-entropy density
subject: relative-entropy production
subject: omega-limit set
subject: non-reversibility
subject: 82C20
subject: 60K35

description: We consider irreversible translation-invariant interacting particle systems on the d-dimensional cubic lattice with finite local state space, which admit at least one Gibbs measure as a time-stationary measure. Under some mild degeneracy conditions on the rates and the specification we prove, that zero relative entropy loss of a translation-invariant measure implies, that the measure is Gibbs w.r.t. the same specification as the time-stationary Gibbs measure. As an application, we obtain the attractor property for irreversible interacting particle systems, which says that any weak limit point of any trajectory of translation-invariant measures is a Gibbs measure w.r.t. the same specification as the time-stationary measure. This extends previously known results to fairly general irreversible interacting particle systems.