cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterizing genetic basis of complex diseases by integrating data-bridge and genomics
Creators: name: He, Jingni
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Education--Health
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Genetics
subject: FOS: Biological sciences

description: With the advancement of high-throughput sequencing and genotyping technology, many multi-omics data are generated in the genomic projects. Such multi-omics data are in between of genotype and phenotype, therefore, may serve as data-bridges to help statistical genetic analyses. How to effectively integrate such data-bridges brings challenges and opportunities for statistical geneticists. For instances, the problem of statistical overfitting, the question of seamlessly integrating biological priors with high-dimensional data, and the interpretation of statistical results in the context of biology. The works in this thesis focus on integrating such data-bridges to characterize the genetic basis of complex diseases and addressing the aforementioned challenges. I have developed novel statistical models of analyzing multi-omics data from four perspectives: (Q1) How to integrate biological priors such as transcription factors with statistical models; (Q2) How to utilize trans- regulatory variants while keeping the model robust despite the large number of possible candidates; (Q3) How to utilize data-bridges to improve the modeling of rare genetic variants; and (Q4) How to utilize brain imaging data in genetic association mapping. These efforts led to four novel statistical models and their implementation: namely, (M1) sTF-TWAS, which integrates the prior knowledge of transcription factors (TF) with association study; (M2) transTF-TWAS, which utilizes Group Lasso to incorporate TF-linked trans-located variants; (M3) rvTWAS, which leverages transcriptome-directed feature selection towards rare variants; and (M4) IMAS, which uses borrowed brain images to conduct image-directed feature selection and aggregations. All these four methods are verified by comprehensive simulations based on known genetic architectures and heritability models. Utilizing the large-scale omics data accessed through dbGaP and UK Biobank, as well as the large cohorts from our collaborator, I have applied them to cancers and neuropsychiatric disorders, yielding the discovery of additional genes underlying complex traits. I have also thoroughly validated the methods by analyzing the discoveries using existing biological literature and databases. The development of these methods opens a door for integrating data-bridges such as transcriptomes and imaging data in genetic mapping. The novel findings provide additional insights into the genetic basis of cancers and brain disorders.
Additional file 7 of Predictive power of extubation failure diagnosed by cough strength: a systematic review and meta-analysis
Creators: name: Duan, Jun
name: Zhang, Xiaofang
name: Song, Jianping
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 7: Figure 7. Forest plot of the positive likelihood ratio (LR) and negative LR in the diagnosis of extubation failure tested by cough peak flow. CI = confidence interval.
Generalized dynamic average modeling of line-commutated converter systems in transient simulation programs
Creators: name: Chiniforoosh, Sina
Publisher: name: University of British Columbia
Year: 2012

description: Power electronic converters are used in a wide range of applications as well as being the enabling technology for interfacing the alternative energy resources and many loads in modern power systems. The methodology of developing the so-called dynamic average-value models (AVMs) for such converters is based on averaging the variables (currents and voltages) within a switching interval resulting in numerically efficient models that are much more suitable than the detailed switching models for system-level studies as well as numerical linearization and the respective small-signal analysis. However, the AVMs available in the literature for line-commutated converters have several limitations such as neglecting the effects of losses, being only valid in certain operational modes and under balanced excitation, as well as employing a simplified representation of the multi-phase transformer in high-pulse-count converters. Moreover, a unified AVM methodology for high-pulse-count converters has not yet been established. In this thesis, a generalized AVM methodology is developed for voltage-source- and rotating-machine-fed multi-pulse line-commutated converters for both classes of transient simulation software packages, i.e., state-variable-based and nodal-analysis-based electromagnetic transient program (EMTP) type. The previously-developed AVM approaches, i.e., analytical and parametric, are extended to the EMTP-type programs, and the indirect and direct methods of interfacing the models with external circuit-network are introduced and compared. For the machine-converter systems, the effects of machine and bridge losses are taken into account in the new AVM. Finally, a generalized dynamic AVM methodology is developed for high-pulse-count converters based on the parametric approach. An effective multi-phase transformer model is developed in transformed (qd0) and phase (abc) variables. An efficient transformer model is also developed, which accurately represents the multi-phase transformer using an equivalent three-phase formulation. The proposed generalized AVM remains valid for all operational modes under balanced and unbalanced excitation. This model is employed for AVM implementation in state-variable-based and EMTP-type programs. Extensive simulation and experimental studies are carried out on several example systems in order to compare the developed AVMs against the detailed and previously-developed average models in time- and frequency-domains. The results demonstrate the great accuracy of the proposed AVMs and a significant improvement compared to the previously-developed models.
Is this a good place to live? A queer narrative hermeneutics of geographies, homes, and bodies
Creators: name: Maine, Emilie Mariah
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: queer
subject: narrative hermeneutics
subject: Alberta
subject: Fort McMurray
subject: Education
subject: Gender Studies

description: This dissertation asks a phenomenological question about the experiences of queer-identifying people, applying a narrative hermeneutic approach to interpret those experiences. This dissertation asks: How do queer people experience what it is like to live in Fort McMurray, Alberta in their homes and in their bodies? Through an embodied epistemology, narrative hermeneutic methodology, and queer theory, this dissertation queries into if Fort McMurray is a good place to live for queer people. Data collected from three collective interviews, and one final individual interview with three participants, provided new knowledge and understandings into how queer people in the northern Canadian urban service area of Fort McMurray learn to work and live in and across three nested systems – geography, home, and body.
DGMT: A Fully Dynamic Hash-Based Group Signature
Creators: name: Erfanian Azad Soltan, Aylar
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Post Quantum Group signature scheme
subject: Architecture
subject: FOS: Civil engineering

description: With the rapid development of quantum technologies, quantum-safe cryptographic schemes have found significant attention. Shor’s quantum algorithms for breaking discrete logarithm (DL) and integer factorization (IF) problems will bring depredation for currently used public key algorithms, including RSA (Rivest–Shamir–Adleman), DH (Diffie-Hellman) key agreement, DSA (Digital Signature Algorithm) and ECC (Elliptic Curve Cryptography), which their security depends on solving mathematical hard problems (IF and DL problem). Therefore, applications and protocols must evolve to be quantum secure in the presence of quantum computers. It is believed that symmetric encryptions and hash functions are resilient to attacks by a quantum adversary. Therefore, signature schemes have been modified so that their security relies on hash functions instead of the aforementioned mathematical hard problems. In this thesis, we consider post-quantum digital group signatures, whose security depends on one-way functions. In practice, these functions are replaced by cryptographic hash functions, which are expected to remain secure in the presence of quantum computers. A group signature is a signature scheme that allows a group member to anonymously sign messages on behalf of the group, while anonymity can be annulled by an opening authority or group manager. In fully dynamic group signature schemes, new members can be added to the group after the initialization phase and existing members can be revoked from the group. The primary aim of this thesis is twofold. Firstly, it aims to conduct a comprehensive analysis of various hash-based group signature schemes, taking into consideration their security models, properties, and limitations. Moreover, this thesis contributes to the development of a novel fully dynamic group signature scheme, named DGMT, which addresses the limitations of previous schemes, and we prove its security (unforgeability, anonymity, and traceability), and provide the complete implementation of the this scheme for the first time. Secondly, the thesis intends to review and evaluate various revocation methods with the objective of identifying potential ways to improve the revocation method utilized in the proposed scheme.
Co-optimization of Operational Unit Commitment and Reserve Power Scheduling for Modern Grid
Creators: name: Mishan, Ramkrishna
name: Egan, Matthew
name: Ben-Idris, Mohammed
name: Livani, Hanif
Publisher: name: arXiv
Year: 2023
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Modern power grids combine conventional generators with distributed energy resource (DER) generators in response to concerns over climate change and long-term energy security. Due to the intermittent nature of DERs, different types of energy storage devices (ESDs) must be installed to minimize unit commitment problems and accommodate spinning reserve power. ESDs have operational and resource constraints, such as charge and discharge rates or maximum and minimum state of charge (SoC). This paper proposes a linear programming (LP) optimization framework to maximize the unit-committed power for a specific optimum spinning reserve power for a particular power grid. Using this optimization framework, we also determine the total dispatchable power, non-dispatchable power, spinning reserve power, and arbitrage power using DER and ESD resource constraints. To describe the ESD and DER constraints, this paper evaluates several factors: availability, dispatchability, non-dispatchability, spinning reserve, and arbitrage factor. These factors are used as constraints in this LP optimization to determine the total optimal reserve power from the existing DERs. The proposed optimization framework maximizes the ratio of dispatchable to non-dispatchable power to minimize unit commitment problems within a specific range of spinning reserve power set to each DER. This optimization framework is implemented in the modified IEEE 34-bus distribution system, adding ten DERs in ten different buses to verify its efficacy.
Comparison of microscopic models for disorder in bilayer graphene: Implications for the density of states and the optical conductivity
Creators: name: Abergel, D. S. L.
name: Min, Hongki
name: Hwang, E. H.
name: Sarma, S. Das
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the effects of disorder on bilayer graphene using four different microscopic models and directly compare their results. We compute the self-energy, density of states, and optical conductivity in the presence of short-ranged scatterers and screened Coulomb impurities, using both the Born approximation and self-consistent Born approximation for the self-energy. We also include a finite interlayer potential asymmetry which generates a gap between the valence and conduction bands. We find that the qualitative behavior of the two scattering potentials are similar, but that the choice of approximation for the self-energy leads to important differences near the band edge in the gapped case. Finally, we describe how these differences manifest in the measurement of the band gap in optical and transport experimental techniques.
description: 11 pages, 6 figures
The Pacific Great Eastern Railway and British Columbia
Creators: name: Stephenson, Paul John
Publisher: name: University of British Columbia
Year: 2012

description: On February 20, 1912, Premier Richard McBride announced the creation of the Pacific Great Eastern (PGE) railway. The line was to be built from Vancouver, 460 miles northeast to Prince George, passing through Squamish, Lillooet, Williams Lake, and Quesnel. McBride committed government guaranteed bonds of $35,000 per mile or $16,100,000 for construction. The construction contract was awarded, without contest, to Foley, Welch and Stewart (FW&S) with a contractual completion date of July 1, 1915. By November 30, 1915, however, FW&S had exhausted all the bond money but had only completed 164 miles of track between Squamish and Clinton. On February 22, 1918 the BC government assumed control of an insolvent PGE project and immediately became liable for interest charges of more than $900,000 annually plus repayment of the principal. This study examines a wide range of primary documents, including a Legislative Select Committee report, British Columbia statutes, Royal Commissions, financial audits, mortgage documents, reports commissioned by the Legislative Assembly, legal records, political debates and newspapers. Comparative, statistical, deductive and economic methodologies are used to support synthesized analysis establishing the culpability of Premier McBride in the mismanagement of the PGE. Statistical analysis of the private and social values of the railway demonstrate that it was not feasible as a private venture and the amount of necessary investment to realize its social value made it an irresponsible project for McBride to initiate given the limited financial capacities of BC in 1912. This study concludes that the failure and ultimate insolvency of the Pacific Great Eastern Railway by 1918 was the result of mismanagement by Premier McBride in letting contracts which were incentive-incompatible with public interests and acted in violation of sections of the Railway Act; opportunistic contractors who, in the interests of maximizing profit, exploited poorly-crafted contracts and provincial government ineptitude; and economic conditions which, prior to 1912, created optimism about the PGE but after 1912 indicated that the project was not viable.
Application of Machine Learning in Different Stages of Oil Reservoir Development
Creators: name: Wei, Liu
Publisher: name: Schulich School of Engineering
Year: 2023
Subjects: subject: Reservoir identification
subject: Production prediction
subject: Pipeline safety
subject: Machine learning
subject: Engineering--Petroleum
subject: Artificial Intelligence

description: Geological and oilfield big data is exponentially expanding. The traditional methods used to identify reservoirs and predict production cannot use historical information and new data effectively. The processes of well logging interpretation and pipeline non-destructive examination (NDE) are time consuming and subjective. Numerical flow simulation models do provide a relatively reliable and appropriate approach to conduct a reservoir analysis, but they are laborious and time consuming. In today’s big data environments, it is increasingly necessary to develop an effective and dependable technique to maximize the benefits of a growing data explosion and extract useful information within all the oilfield data. A machine learning method incorporates various algorithms that provide powerful functions in an oilfield. Massive static and dynamic data is put into training models to identify valuable features and learn nonlinear relationships between different variables and output targets. Advanced models using the benefits of machine learning (ML) will help operators to implement classification and/or prediction tasks. This study compares various ML methods applied to different stages from oil and gas exploration to transportation in oilfields: reservoir identification, prediction of production in new and old wells and non-destructive examination (NDE) of pipelines. These ML methods are proven useful and fast to resolve reservoir classification and production prediction challenges. This work provides a set of systematic ML methods and their respective pertinent predicting parameters providing useful experiences and references for industry and future relative research.
Pygmy dipole resonance: collective features and symmetry energy effects
Creators: name: Baran, V.
name: Frecus, B.
name: Colonna, M.
name: Di Toro, M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A very important open question related to the pygmy dipole resonance is about its quite elusive collective nature. In this paper, within a harmonic oscillator shell model, generalizing an approach introduced by Brink, we first identify the dipole normal modes in neutron rich nuclei and derive the energy weighted sum rule exhausted by the pygmy dipole resonance. Then solving numerically the self-consistent Landau-Vlasov kinetic equations for neutrons and protons with specific initial conditions, we explore the structure of the different dipole vibrations in the $^{132}Sn$ system and investigate their dependence on the symmetry energy. We evidence the existence of a distinctive collective isoscalar-like mode with an energy well below the Giant Dipole Resonance (GDR), very weakly dependent on the isovector part of the nuclear effective interaction. At variance the corresponding strength is rather sensitive to the behavior of the symmetry energy below saturation, which rules the number of excess neutrons in the nuclear surface.
description: 5 pages, 4 figures; an additional section on the role of the symmetry energy upon EWSR exhausted by the pygmy mode is included
Casearia obliqua Spreng.
Creators: name: Maia, Valéria Cid
name: Mascarenhas, Bernardo
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Salicaceae
Casearia
Casearia obliqua

description: Casearia obliqua Spreng. (n = 1)
 Gall: on leaf midvein, fusiform, green, glabrous, two-chambered. Gall-inducer: not determined. Trail: Teresópolis: Barragem road (between Primavera entrances) (13.IX.2021).
First gall record on this plant species.
description: Published as part of Maia, Valéria Cid & Mascarenhas, Bernardo, 2023, Insect galls of Parque Nacional da Serra dos Órgãos (Rio de Janeiro State, Southeastern Brazil), pp. 1-56 in Papéis Avulsos de Zoologia 63 on page 45, DOI: 10.11606/1807-0205/2023.63.040, http://zenodo.org/record/10270483
Teachers Reflecting on Study Abroad
Creators: name: Beamer, Kate
name: Schnider, Raina
name: Dressler, Roswita
name: Kawalilak, Colleen
Publisher: name: Werklund School of Education
Year: 2022

description: This annotated bibliography provides a review of studies on the personal and professional learning that emerges for in-service teachers who took part in a pre-service sojourn. Specifically, these studies examined longitudinal outcomes from teachers who engaged in reflective practices. These studies inform study abroad research into the longitudinal outcomes of sojourns in professional programs.
Some examples of different descriptions of energy-momentum density in the context of Bianchi IX cosmological model
Creators: name: Nourinezhad, Z.
name: Mehdipour, S. Hamid
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Based on the Bianchi type IX metric, we calculate the energy and momentum density components of the gravitational field for the five different definitions of energy-momentum, namely, Tolman, Papapetrou, Landau-Lifshitz, Møller and Weinberg. The energy densities of Møller and Weinberg become zero for the spacetime under consideration. In the other prescriptions, i.e., Tolman, Papapetrou and Landau-Lifshitz complexes, we find different non-vanishing energy-momentum densities for the given spacetime, supporting the well-known argument in General Relativity that the different definitions may lead to different distributions even in the same spacetime background.
description: 11 pages, no figure, typos corrected, accepted for publication in Indian J. Phys
Completely bounded representations of convolution algebras of locally compact quantum groups
Creators: name: Brannan, Michael
name: Daws, Matthew
name: Samei, Ebrahim
Publisher: name: arXiv
Year: 2011
Subjects: subject: Operator Algebras (math.OA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 20G42, 22D12, 22D15, 43A30, 46L07, 46L51, 46L89, 81R50

description: Given a locally compact quantum group $\mathbb G$, we study the structure of completely bounded homomorphisms $π:L^1(\mathbb G)\rightarrow\mathcal B(H)$, and the question of when they are similar to $\ast$-homomorphisms. By analogy with the cocommutative case (representations of the Fourier algebra $A(G)$), we are led to consider the associated map $π^*:L^1_\sharp(\mathbb G) \rightarrow \mathcal B(H)$ given by $π^*(ω) = π(ω^\sharp)^*$. We show that the corepresentation $V_π$ of $L^\infty(\mathbb G)$ associated to $π$ is invertible if and only if both $π$ and $π^*$ are completely bounded. Moreover, we show that the co-efficient operators of such representations give rise to completely bounded multipliers of the dual convolution algebra $L^1(\hat \mathbb G)$. An application of these results is that any (co)isometric corepresentation is automatically unitary. An averaging argument then shows that when $\mathbb G$ is amenable, $π$ is similar to a *-homomorphism if and only if $π^*$ is completely bounded. For compact Kac algebras, and for certain cases of $A(G)$, we show that any completely bounded homomorphism $π$ is similar to a *-homomorphism, without further assumption on $π^*$. Using free product techniques, we construct new examples of compact quantum groups $\mathbb G$ such that $L^1(\mathbb G)$ admits bounded, but not completely bounded, representations.
description: 35 pages; some re-writing; new results added on (co)isometric corepresentations, free products and non-cb representations
A Multi-Epoch, Simultaneous Water and Methanol Maser Survey toward Intermediate-Mass Young Stellar Objects
Creators: name: Bae, Jae-Han
name: Kim, Kee-Tae
name: Youn, So-Young
name: Kim, Won-Ju
name: Byun, Do-Young
name: Kang, Hyunwoo
name: Oh, Chung Sik
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report a multi-epoch, simultaneous 22 GHz H2O and 44 GHz class I CH3OH maser line survey towards 180 intermediate-mass young stellar objects, including 14 Class 0, 19 Class I objects, and 147 Herbig Ae/Be stars. We detected H2O and CH3OH maser emission towards 16 (9%) and 10 (6%) sources with one new H2O and six new CH3OH maser sources. The detection rates of both masers rapidly decrease as the central (proto)stars evolve, which is contrary to the trends in high-mass star-forming regions. This suggests that the excitations of the two masers are closely related to the evolutionary stage of the central (proto)stars and the circumstellar environments. H2O maser velocities deviate on average 9 km s^-1 from the ambient gas velocities whereas CH3OH maser velocities match quite well with the ambient gas velocities. For both maser emissions, large velocity differences (|v_{H2O} - v_{sys} | > 10 km s^-1 and |v_{CH3OH} - v_{sys}| > 1 km s^-1) are mostly confined to Class 0 objects. The formation and disappearance of H2O masers is frequent and their integrated intensities change by up to two orders of magnitude. In contrast, CH3OH maser lines usually show no significant change in intensity, shape, or velocity. This is consistent with the previous suggestion that H2O maser emission originates from the base of an outflow while 44 GHz class I CH3OH maser emission arises from the interaction region of the outflow with the ambient gas. The isotropic maser luminosities are well correlated with the bolometric luminosities of the central objects. The fitted relations are L_{H2O} = 1.71 * 10^{-9} (L_{bol})^{0.97} and L_{CH3OH} = 1.71 * 10^{-10} (L_{bol})^{1.22}.
description: Accepted to ApJS, 40 pages, 9 figures, 9 tables
DEP Bulletin:Volume 38 Issue 9
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2014

description: The DEP bulletin is a semi-monthly publication of the New Jersey Department of Environmental Protection. It contains a list of construction permit applications recently filed or acted upon by the Department along with a calendar of events of interest, a schedule of public hearings, and Environmental Impact Statements acted upon during the period.
Sur la fidélité de certaines représentations de GL_2(F) sous une algèbre d'Iwasawa
Creators: name: Yongquan, Hu
name: Stéfano, Morra
name: Benjamin, Schraen
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: Let F be a finite extension of Qp, O_F its ring of integers and E a finite extension of Fp. The natural action of the unit group O_F* on O_F extends in a continuous action on the Iwasawa algebra E[[O_F]]. In this work, we show that non zero ideals of E[[O_F]] which are stable under O_F* are open. As a consequence, we deduce the fidelity of the action of E[[U]], with U the subgroup of upper unipotent matrices in GL2(O_F) on an irreducible admissible smooth E-representation of GL2(F). ----- Soit F une extension finie de Qp, d'anneau des entiers O_F et E une extension finie de Fp. L'action naturelle du groupes des unités O_F* sur O_F se prolonge alors en une action continue sur l'algèbre d'Iwasawa E[[O_F]]. Dans ce travail, on démontre que les idéaux non nuls de E[[O_F]] stables par O_F* sont ouverts. En particulier, on en déduit la fidélité de l'action de l'algèbre d'Iwasawa des matrices unipotentes supérieures de GL2(O_F) sur une représentation lisse irréductible admissible de GL2(F).
description: 13 pages, in french
Beheading Canada’s History: The Desecration of Sir John A. Macdonald’s image in the Canadian National Memory
Creators: name: Walker, Kelsie Lynn
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Canada
subject: Canadian History
subject: Political Science
subject: FOS: Political science
subject: Sir John A. Macdonald
subject: Confederation
subject: National Memory
subject: History--Modern
subject: History--Canadian
subject: Political Science
subject: History

description: The image of Canada’s first Prime Minister, Sir John A. Macdonald, has rapidly deteriorated. In the 1950s, Macdonald was regarded as one of Canada’s greatest statesmen, where both historiographical and public esteem for him was at its peak. However, in the 1970s the desecration of his image began both in the public square and in contemporary debates about his stature in historiography. No figure in Canadian history has seen as drastic and unforgiving of a decline as Macdonald. Fuelled by growing trends of revisionism, presentism, and “wokeism,” Macdonald’s legacy is being destroyed as Canadian history is increasingly studied through the lens of morality, condemning imperfections and ignoring historical context. As a result, the grievances of contemporary Canada are placed on Macdonald as a way to help Canadians come to terms with the elements of Canada’s foundation that do not fit into the narratives of “progressivism,” “tolerance,” and “multiculturalism.” Macdonald’s image has been inaccurately distorted, questioned, and actively diminished, rendering him guilty of committing many of the injustices in Canada’s history. Today’s Macdonald is often viewed as a racist, genocidal tyrant, reduced to a caricature of his shortcomings and diminished as a drunk. However, movements to reclaim the accurate image of Macdonald are being undertaken. This thesis explores the current debate surrounding Macdonald’s legacy and examines how his image has changed throughout Canada’s history. I ultimately argue that to properly understand Macdonald, the two images that dominate contemporary historiography, one of him as a heroic nation builder and the other of him as a genocidal tyrant, must be examined in historical context and in tandem with one another. While the new, distorted image of Macdonald is loudly and viciously proclaimed, it is not welcomed by many.
Additional file 7 of Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis
Creators: name: Ellul, Pierre
name: Rosenzwajg, Michelle
name: Peyre, Hugo
name: Fourcade, Gwladys
name: Mariotti-Ferrandiz, Encarnita
name: Trebossen, Vincent
name: Klatzmann, David
name: Delorme, Richard
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 7. Characteristics of Th17 studies.
Highly charged ions in Penning traps, a new tool for resolving low lying isomeric states
Creators: name: Gallant, A. T.
name: Brodeur, M.
name: Brunner, T.
name: Chowdhury, U.
name: Ettenauer, S.
name: Simon, V. V.
name: Mané, E.
name: Simon, M. C.
name: Andreoiu, C.
name: Delheij, P.
name: Gwinner, G.
name: Pearson, M. R.
name: Ringle, R.
name: Dilling, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The use of highly charged ions increases the precision and resolving power, in particular for short-lived species produced at on-line radio-isotope beam facilities, achievable with Penning trap mass spectrometers. This increase in resolving power provides a new and unique access to resolving low-lying long-lived ($T_{1/2} > 50$ ms) nuclear isomers. Recently, the $111.19(22)$ keV (determined from $γ$-ray spectroscopy) isomeric state in $^{78}$Rb has been resolved from the ground state, in a charge state of $q=8+$ with the TITAN Penning trap at the TRIUMF-ISAC facility. The excitation energy of the isomer was measured to be $108.7(6.4)$ keV above the ground state. The extracted masses for both the ground and isomeric states, and their difference, agree with the AME2003 and Nuclear Data Sheet values. This proof of principle measurement demonstrates the feasibility of using Penning trap mass spectrometers coupled to charge breeders to study nuclear isomers and opens a new route for isomer searches.
description: 8 pages, 6 figures
Sur la présentation des représentations supersingulières de $\mathrm{GL}_2(F)$
Creators: name: Schraen, Benjamin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Representation Theory (math.RT)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 22E50, 11F33

description: Let $F$ be a quadratic extension of $\mathbb{Q}_p$. We prove that smooth irreducible supersingular representations with central character of $\mathrm{GL}_2(F)$ are not of finite presentation.
description: 19 pages, minor mistakes corrected, minor changes of notation
Exploring Antimicrobial Resistance in Escherichia coli: A Scoping Review Protocol Comparing Antibiotic-free and Conventionally Raised Beef Cattle in North America
Creators: name: Sanguinetti, Verónica María
name: Davies, Willow-Bethany O.
name: Ganshorn, Heather
name: Checkley, Sylvia L.
Publisher: name: Veterinary Medicine
Year: 2023
Subjects: Escherichia coli
E. coli
antimicrobial resistance
beef cattle
antibiotic-free beef

description: Escherichia coli is a gram-negative bacterium commonly found in the human and animal gastrointestinal tract. Beef cattle are considered reservoirs, although some strains can trigger diarrhea in newborn calves. Certain strains, such as Shiga toxin-producing E. coli (STECs), pose health risks in humans and animals [2]. Antibiotic resistance in E. coli is a significant concern in human and veterinary medicine, as it can lead to treatment challenges and transmission to other bacteria [3]. Canada and the United States Drug-Resistant Index score lie among the lowest ten countries, and this can be associated with the wide use of narrow-spectrum penicillin [4]. Strains encode accessory resistance and are likely resistant to multiple antibiotic classes [5]. Evidence suggests that E. coli can be resistant to more than one antimicrobial drug, and the most common resistance phenotypes are older drugs such as tetracycline, sulfonamide, streptomycin, and ampicillin [6]. Antibiotic-free beef cattle certifications have been implemented to address antimicrobial resistance concerns in the food chain [7]. However, the evidence regarding the prevalence of resistant bacteria in antibiotic-free production systems is limited. Antimicrobial resistance in Escherichia coli represents a significant One Health issue, highlighting the urgent need to explore alternatives, such as limiting the use of antibiotics in beef cattle production to therapeutic treatments, to mitigate the spread of resistant strains and safeguard human and animal health [8]. Objectives The objective of this study is to lead a scoping review to define the range of existing research in the area, individualize research gaps and suggest areas important for future research studies about Antimicrobial Resistance in Escherichia coli of Antibiotic-free and Conventionally Raised Beef Cattle from North America. Methods This scoping review has been designed following the JBI Reviewer’s Manual [9] and the PRISMA ScR guidelines for scoping reviews [1] to report it and the search question was constructed using the PICO framework. We will search the literature for peer-reviewed articles using the following databases: CAB Abstracts, BIOSIS Previews, Environmental Complete, the Web of Science’s Science Citation Index and Emerging Sources Citation Index. The grey literature search will include a search of ProQuest Dissertations and the websites of relevant government departments, agencies, and industry groups. Two independent reviewers will screen the articles at the title, abstract, and full-text levels.
Quasi-likelihood for Spatial Point Processes
Creators: name: Guan, Yongtao
name: Jalilian, Abdollah
name: Waagepetersen, Rasmus
Publisher: name: arXiv
Year: 2013
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Fitting regression models for intensity functions of spatial point processes is of great interest in ecological and epidemiological studies of association between spatially referenced events and geographical or environmental covariates. When Cox or cluster process models are used to accommodate clustering not accounted for by the available covariates, likelihood based inference becomes computationally cumbersome due to the complicated nature of the likelihood function and the associated score function. It is therefore of interest to consider alternative more easily computable estimating functions. We derive the optimal estimating function in a class of first-order estimating functions. The optimal estimating function depends on the solution of a certain Fredholm integral equation which in practice is solved numerically. The approximate solution is equivalent to a quasi-likelihood for binary spatial data and we therefore use the term quasi-likelihood for our optimal estimating function approach. We demonstrate in a simulation study and a data example that our quasi-likelihood method for spatial point processes is both statistically and computationally efficient.
Unifying the social landscape with OpenMe
Creators: name: Tsao, Vincent
Publisher: name: University of British Columbia
Year: 2012

description: With the rapid rise of the popularity of online social networks (OSNs) in recent years, we have seen tremendous growth in the number of available OSNs. With newer OSNs attempting to draw users in by focussing on specific services or themes, it is becoming clearer that OSNs do not compete on the quality of their technology but rather the number of active users. This leads to vendor lock-in, which creates problems for users managing multiple OSNs or wanting to switch OSNs. Third party applications are often written to alleviate these problems but often find it difficult to deal with the differences between OSNs. These problems are made worse as we argue that a user will inevitably switch between many OSNs in his or her lifetime due to OSNs being incredibly fashionable things whose lifespan is dependent on social trends. Thus, these applications often only support a limited number of OSNs. This thesis examines how it is possible to help developers write apps that run against multiple OSNs. It describes the need for and presents a novel set of abstractions for apps to use to interface with OSNs. These abstractions are highly expressive, future proof, and removes the need for an app to know which OSNs it is running against. Two evaluations were done to determine the strength of these abstractions. The first evaluation analyzed the expressiveness of the abstractions while the latter analyzed the feasibility of the abstractions. The contributions of this thesis are a first step to better understanding how OSNs can be described at a high level.
Evading quantum mechanics
Creators: name: Tsang, Mankei
name: Caves, Carlton M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum mechanics is potentially advantageous for certain information-processing tasks, but its probabilistic nature and requirement of measurement back action often limit the precision of conventional classical information-processing devices, such as sensors and atomic clocks. Here we show that by engineering the dynamics of coupled quantum systems, it is possible to construct a subsystem that evades the measurement back action of quantum mechanics, at all times of interest, and obeys any classical dynamics, linear or nonlinear, that we choose. We call such a system a quantum-mechanics-free subsystem (QMFS). All of the observables of a QMFS are quantum-nondemolition (QND) observables; moreover, they are dynamical QND observables, thus demolishing the widely held belief that QND observables are constants of motion. QMFSs point to a new strategy for designing classical information-processing devices in regimes where quantum noise is detrimental, unifying previous approaches that employ QND observables, back-action evasion, and quantum noise cancellation. Potential applications include gravitational-wave detection, optomechanical force sensing, atomic magnetometry, and classical computing. Demonstrations of dynamical QMFSs include the generation of broad-band squeezed light for use in interferometric gravitational-wave detection, experiments using entangled atomic spin ensembles, and implementations of the quantum Toffoli gate.
description: v2: changed the title, added a figure, and made some minor updates
Continuous-Time Portfolio Choice Under Monotone Mean-Variance Preferences-Stochastic Factor Case
Creators: name: Trybuła, Jakub
name: Zawisza, Dariusz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Portfolio Management (q-fin.PM)
subject: Probability (math.PR)
subject: FOS: Economics and business
subject: FOS: Mathematics
subject: 91G10, 91A15, 91A23, 93E20

description: We consider an incomplete market with a nontradable stochastic factor and a continuous time investment problem with an optimality criterion based on monotone mean-variance preferences. We formulate it as a stochastic differential game problem and use Hamilton-Jacobi-Bellman-Isaacs equations to find an optimal investment strategy and the value function. What is more, we show that our solution is also optimal for the classical Markowitz problem and every optimal solution for the classical Markowitz problem is optimal also for the monotone mean-variance preferences. These results are interesting because the original Markowitz functional is not monotone, and it was observed that in the case of a static one-period optimization problem the solutions for those two functionals are different. In addition, we determine explicit Markowitz strategies in the square root factor models.
description: Major revision, the same model but the main result is strenghtened, the square root factor model added (Heston model)
Une interprétation modulaire de la variété trianguline
Creators: name: Breuil, Christophe
name: Hellmann, Eugen
name: Schraen, Benjamin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 11F85, 22E50

description: Using a patching module constructed in recent work of Caraiani, Emerton, Gee, Geraghty, Pa{š}k{ū}nas and Shin we construct some kind of analogue of an eigenvariety. We can show that this patched eigenvariety agrees with a union of irreducible components of a space of trianguline Galois representations. Building on this we discuss the relation with the modularity conjectures for the crystalline case, a conjecture of Breuil on the locally analytic socle of representations occurring in completed cohomology and with a conjecture of Bellaïche and Chenevier on the complete local ring at certain points of eigenvarieties.
description: in French
ХОТИН-ҚИЗЛАРГА НИСБАТАН ЗЎРАВОНЛИКЛАРНИ ОЛДИНИ ОЛИШДА ҲУҚУҚИЙ АСОСЛАРНИ ТАКОМИЛЛАШИШИГА ЗАРУРАТ
Creators: name: Қушбоқов, Шоҳрух
name: Раимқулов, Иззат
Publisher: name: Zenodo
Year: 2023

description: Мамлакатимизда сўнгги йилларда хотин қизлар ва уларнинг ҳақ ҳуқуқлари ва қонуний манфаатларини тўла  ҳимоя  қилиш ва  жамиятга  сингдириш билан  боғлиқ  амалга оширилаётган  ислоҳотлар диққатга  сазовордир.  Хусусан мамлакатда  хотин-қизларнинг  ҳуқуқ ва  қонуний  манфаатларини ҳимоя  қилиш,  уларнинг иқтисодий, ижтимоий  ва  сиёсий фаоллигини  ошириш,  соғлиғини сақлаш,  касбга  ўқитиш ва бандлигини таъминлаш, тадбиркорликка кенг жалб этиш, эҳтиёжманд хотин-қизларни ижтимоий қўллаб-қувватлаш,  гендер  тенгликни таъминлаш  борасида  олиб борилаётган  ислоҳотларни тизимли  давом  эттириш, ҳозири  давлат  сиёсатининг асосий мақсадига айланди
Laboratory Use in Individuals with Early-Onset versus Usual-Onset of Diabetes: A Retrospective Cohort Study
Creators: name: Sriskandarajah, Apishanthi
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Epidemiology

description: Background: The incidence and prevalence of diabetes is increasing in younger individuals and these individuals are at an increased risk of complications. Laboratory testing is used to screen and monitor for complications in people with diabetes, and there is concern that this is not being achieved as per clinical guidelines. The objective of this thesis was to describe the frequency and results of guideline recommended laboratory tests in individuals with early-onset (<40 years of age) and usual-onset diabetes (≥40 years of age), and to explore clinical and sociodemographic factors related to guideline concordance of frequency of testing and results. Methods: This observational, retrospective cohort study used population-based administrative and clinical databases in Alberta from 2018 to 2019. We included adults with incident diabetes (age ≥18 years) and stratified by age of onset (<40 years versus ≥40 years). Individuals were followed for a total of 365 days for glycated hemoglobin (A1C), low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), and albumin to creatinine ratio (ACR) tests. Descriptive statistics were used to compare laboratory testing between early-onset and usual-onset groups. Multivariable logistic regression was used to assess factors related to guideline concordant testing frequency and above-target results. Results: Overall, the cohort included 23,643 individuals with incident diabetes (mean age 54.1 ± SD 15.4 years, 42.1% female). The early-onset group represented 18.9% of the cohort. A higher proportion of the early-onset group had lower frequency of testing for A1C, LDL-C, eGFR, and ACR tests and above-target test results for A1C and LDL-C compared to the usual-onset group. After adjustment of covariates (sex, socioeconomic status, rural residence, medication use), the early-onset group was more likely to have lower frequency of testing for A1C, LDL-C, and eGFR tests and above-target A1C and LDL-C levels compared to the usual-onset group. Sociodemographic and clinical factors were also associated with testing frequency and above-target test results. Conclusions: Despite a universal health care system, the early-onset group was not meeting clinical guidelines for testing frequency or targets. Future work is needed to inform tools and strategies to improve guideline recommended laboratory use in this group.
Equations of state and compact stars in gauge/gravity duality
Creators: name: Kim, Kyung Kiu
name: Kim, Youngman
name: Shin, Ik Jae
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose a new doorway to study the interplay between equations of state of dense matter and compact stars in gauge/gravity correspondence. For this we construct a bulk geometry near the boundary of five-dimensional spacetime. By solving a constraint equation derived from the bulk equation of motion together with the Tolman-Oppenheimer-Volkoff equation, we determine the equations of state for compact stars. The input parameters in this study are the energy density and pressure at the center of the compact objects. We also study how the equation of state depends on the parameters.
description: 15 pages, 9 figures, v2: version accepted for publication in JHEP
From Community Networks to Community Data: The AppLea Farming Mobile App
Creators: name: Pilichos, Aris
name: Karaliopoulos, Merkouris
name: Koutsopoulos, Iordanis
Publisher: name: Zenodo
Year: 2019

description: We present AppLea, an open source farming Android application that aspires to become the online assistant of farmers and stock-farmers with their daily activities. The app has been developed in close cooperation with the farming community of fourteen villages in Thessaly, Greece, which have access to the Internet thanks to the Sarantaporo.gr community network. Its mission is threefold: (a) to serve as the online logbook of daily activities in the farm, easing their planning, recording and reporting to agronomists and cooperatives; (b) to foster the sharing of data about good (and bad) farming practices among the community; (c) to become an asset for the provision of advanced smart farming services to its members. We describe the main capabilities of the app, which aims to multiply the value of the local community network for the local economy and actively contribute to the sustainability of both