cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Target prediction, computational identification, and network-based pharmacology of most potential phytoconstituent in medicinal leaves of Justicia adhatoda against SARS-CoV-2
Creators: name: Dagur, Pankaj
name: Rakshit, Gourav
name: Sheikh, Murtuja
name: Biswas, Abanish
name: Jha, Parineeta
name: Al-Khafaji, Khattab
name: Ghosh, Manik
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The current global epidemic of the novel coronavirus (SARS-CoV-2) has been labeled a global public health emergency since it is causing substantial morbidity and mortality on daily basis. We need to identify an effective medication against SARS-CoV-2 because of its fast dissemination and re-emergence. This research is being carried out as part of a larger strategy to identify the most promising therapeutic targets using protein-protein interactions analysis. Mpro has been identified as one of the most important therapeutic targets. In this study, we did in-silico investigations to identify the target and further molecular docking, ADME, and toxicity prediction were done to assess the potential phyto-active antiviral compounds from Justicia adhatoda as powerful inhibitors of the Mpro of SARS-COV-2. We also investigated the capacity of these molecules to create stable interactions with the Mpro using 100 ns molecular dynamics simulation. The highest scoring compounds (taraxerol, friedelanol, anisotine, and adhatodine) were also found to exhibit excellent solubility and pharmacodynamic characteristics. We employed MMPBSA simulations to assess the stability of docked molecules in the Mpro binding site, revealing that the above compounds form the most stable complex with the Mpro. Network-based Pharmacology suggested that the selected compounds have various modes of action against SARS-CoV-2 that include immunoreaction enrichment, inflammatory reaction suppression, and more. These findings point to a promising class of drugs that should be investigated further in biochemical and cell-based studies to see their effectiveness against nCOVID-19. Communicated by Ramaswamy H. Sarma
Statistically consistent coarse-grained simulations for critical phenomena in complex networks
Creators: name: Chen, Hanshuang
name: Hou, Zhonghuai
name: Xin, Houwen
name: Yan, YiJing
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Computational Physics (physics.comp-ph)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We propose a degree-based coarse graining approach that not just accelerates the evaluation of dynamics on complex networks, but also satisfies the consistency conditions for both equilibrium statistical distributions and nonequilibrium dynamical flows. For the Ising model and susceptible-infected-susceptible epidemic model, we introduce these required conditions explicitly and further prove that they are satisfied by our coarse-grained network construction within the annealed network approximation. Finally, we numerically show that the phase transitions and fluctuations on the coarse-grained network are all in good agreements with those on the original one.
description: 7 pages, 6 figures
Spurious predictions with random time series: The Lasso in the context of paleoclimatic reconstructions. Discussion of: A statistical analysis of multiple temperature proxies: Are reconstructions of surface temperatures over the last 1000 years reliable?
Creators: name: Tingley, Martin P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Discussion of "A statistical analysis of multiple temperature proxies: Are reconstructions of surface temperatures over the last 1000 years reliable?" by B.B. McShane and A.J. Wyner [arXiv:1104.4002]
description: Published in at http://dx.doi.org/10.1214/10-AOAS398E the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Di-neutron clustering and deuteron-like tensor correlation in nuclear structure focusing on 11Li
Creators: name: Ikeda, Kiyomi
name: Myo, Takayuki
name: Kato, Kiyoshi
name: Toki, Hiroshi
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: 11Li is a Borromean nucleus, where two out of three objects as 9Li + n and two neutrons independently do not form bound systems. Two neutrons should form a di-neutron cluster in the nuclear field generated by the 9Li core nucleus. We treat di-neutron clustering by solving the two neutron relative wave function precisely by using the bare nucleon-nucleon interaction so that the spatial clustering structure is obtained quantitatively within the whole 11Li nucleus. This di-neutron clustering is an essential dynamics to form the halo structure by making a compact di-neutron cluster, which distributes loosely around the 9Li core. The di-neutron clustering is a new concept and is a general phenomenon in neutron skin and neutron halo nuclei. This quantitative description of di-neutron clustering has made it necessary to consider another important deuteron-like tensor correlation, which is caused by strong tensor interaction in the nucleon-nucleon interaction. The tensor interaction originates from pion exchange and known to provide large attraction to form the 4He nucleus. The unique feature of the tensor correlation is to make highly correlated deuteron-like excitation, which interferes with shell model like structure in a unique way. This dynamical effect removes the magic number effect and makes easy the participation of the s-wave neutrons. Hence, there are pairing and deuteron-like tensor correlations in addition to the mean field structure in 9Li. The combined system of two additional neutrons with the correlated 9Li provides the halo phenomenon, in which the di-neutron clustering develops with the help of large s-wave component caused by the deuteron-like tensor correlation. In this lecture note, we would like to introduce these two new concepts in a systematic manner and fill a gap between the halo phenomenon and the microscopic reason for this interesting phenomenon.
description: 58 pages, to be published in Lecture Note in Physics Vol. 818 (Springer), "Clusters in Nuclei" Volume 1, corrected figures
Environmental justice and the enforcement of air pollution laws in Canada
Creators: name: Ewing, Claire
Publisher: name: University of British Columbia
Year: 2021

description: Ambient air pollution is one of the leading health and environmental concerns worldwide, including in Canada. To manage air pollution and its impacts, Canadian governments create and enforce various laws and regulations. Most areas in Canada usually experience good air quality, but some communities are disproportionately exposed to harmful air pollution, constituting an environmental injustice. While these concepts of ambient air pollution, environmental enforcement, and environmental justice have each been studied either in isolation or in pairs in Canada, no research has examined the three together. In particular, patterns of enforcement of air pollution laws are understudied, and it is not known whether enforcement varies according to the characteristics of different communities. This study seeks to address these gaps and investigate the nexus of air pollution, environmental law enforcement, and environmental justice in Canada by examining the following research questions: RQ1: How do enforcement data availability and quality vary between and within provinces? RQ2: What are the demonstrated models of enforcement? How do they vary across jurisdictions, time, or other factors? RQ3: What types of violations or offenders appear to be prioritized for enforcement action in Canada? RQ4: How are the sociodemographic characteristics of areas in which enforcement actions occur different from the provincial averages of those characteristics? I created a dataset of enforcement actions against air pollution law violations using data gathered from eight provinces and the federal government, which I then analyzed using descriptive statistics and geospatial techniques. I developed a rubric to evaluate and compare jurisdictions’ data availabilities and qualities and found that all were generally poor and incomplete, which violates the community right to know and the individual right to information. Through descriptive statistics, I observed that across provincial and federal jurisdictions, regulators appear to employ a cooperative approach to enforcement. Environmental priorities and enforcement outcomes do not seem to align on several levels, especially regarding large emitters and repeat offenders of air pollution laws. Finally, geospatial analyses revealed some environmental injustice patterns related to the location of enforcement actions. I offer several recommendations to improve enforcement strategies within and beyond existing policy systems.
Multi-strange baryon measurements at LHC energies, with the ALICE experiment
Creators: name: Maire, Antonin
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The status of the charged multi-strange baryon analysis (Xi-, anti-Xi+, Omega-, anti-Omega+) at LHC energies is presented. This report is based on the results obtained with ALICE (A Large Ion Collider Experiment), profiting from the characteristic cascade-decay topology. A special attention is drawn to the early pp data-taking period (2009-2010) and subsequently, on the uncorrected pT-spectra extracted at mid-rapidity for centre of mass energies of 0.9 TeV and 7 TeV.
description: 4 pages, 5 figures, Hot Quarks 2010 proceedings, La Londe Les Maures, France, June 2010 (to be published in Journal of Physics: Conference Series)
title: ÐÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ðµ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ðµ Ð°Ð³ÐµÐ½ÑÑÑÐ²Ð° Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²ÑÑ ÑÑÐ»ÑÐ³
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Communication promotion of marketing services agency
Creators: name: ÐÐ°Ð²Ð¸Ð´ÐµÐ½ÐºÐ¾, ÐÐ½Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ðµ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ðµ
ÐºÐ°Ð½Ð°Ð»Ñ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸
Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ðµ Ð°Ð³ÐµÐ½ÑÑÑÐ²Ð¾
ÑÑÐµÐ½Ð´Ñ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ
ÐºÐ¾Ð½ÐºÑÑÐµÐ½ÑÐ½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð·
Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÐ½ÐºÐ°
communication promotion
communication channels
marketing agency
promotion trends
competitive analysis
market research

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ñ ÑÐ¿ÐµÑÐ¸ÑÐ¸ÐºÐ¸ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ð³Ð¾ Ð°Ð³ÐµÐ½ÑÑÑÐ²Ð° Â«ÐÑÑÑÐ½Ð¸ÐºÐ°Â», Ð° ÑÐ°ÐºÐ¶Ðµ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ñ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÑ Ð¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÑ ÐºÐ°Ð½Ð°Ð»Ð¾Ð² ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÐºÐ°Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Ð² ÑÐ¾Ñ. ÑÐµÑÑÑ. Ð Ð°ÑÐºÑÑÐ²Ð°ÑÑÑÑ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ½Ð¾Ð²Ñ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð¸ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²ÑÑ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¹ Ð² ÑÐµÐ»Ð¾Ð¼. ÐÑÐ¾Ð±ÑÐ°Ð¶Ð°ÐµÑÑÑ ÑÐ¿ÐµÑÐ¸ÑÐ¸ÐºÐ° ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð½Ð° ÑÑÐ½ÐºÐµ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²ÑÑ ÑÑÐ»ÑÐ³. ÐÐ¿Ð¸ÑÐ°Ð½Ñ Ð¿Ð¾ÑÐ»ÐµÐ´Ð½Ð¸Ðµ ÑÑÐµÐ½Ð´Ñ Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð½Ð° ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¼ Ð¸ Ð·Ð°ÑÑÐ±ÐµÐ¶Ð½Ð¾Ð¼ ÑÑÐ½ÐºÐµ.
description: The work is devoted to the analysis of the specifics of the communication activities of the marketing agency "Brusnika", as well as the identification of the most relevant and effective channels of communication promotion for planning a communication campaign in the social networks. The theoretical foundations of communication promotion and marketing communications in general are revealed. The specificity of communication promotion in the marketing services market is displayed. The latest promotion trends in the Russian and foreign markets are described.
Assessing the effect of a series of mutations on the dynamic behavior of phosphite dehydrogenase using molecular docking, molecular dynamics and quantum mechanics/molecular mechanics simulations
Creators: name: Baammi, Soukayna
name: Daoud, Rachid
name: Allali, Achraf El
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Discovered in Pseudomonas stutzeri, phosphite dehydrogenase (PTDH) is an enzyme that catalyzes the oxidation of phosphite to phosphate while simultaneously reducing NAD+ to NADH. Despite several investigations into the mechanism of reaction and cofactor regeneration, only a few studies have focused on improving the activity and stability of PTDH. In this study, we combine molecular docking, molecular dynamics (MD) simulation, and Quantum Mechanics/Molecular Mechanics (QM/MM) to identify the impact of 30 mutations on the activity and stability of PTDH. Molecular docking results suggest that E266Q, K76A, K76M, K76R, K76C, and R237K can act on the NAD+ binding site through relatively weak bond development due to their high free binding energy. Moreover, Mulliken population analysis and potential energy barrier indicate that T101A, E175A, E175A/A176R, A176R, and E266Q act on phosphite oxidation. The mutants M53N, M53A, K76R, D79N, D79A, T101A, W134A, W134F Y139F, A146S, E175A, F198I, F198M, E266Q, H292K, S295A, R301K, and R301A were found to act on the structural dynamic of PTDH. The remaining mutants cause the loss of the nitrogen atom of R237 and H292, respectively, inactivating the enzyme. This study provides specific explanations of how mutations affect weak interactions of PTDH. The results should allow researchers to conduct experimental studies to improve PTDH activity and stability. Communicated by Ramaswamy H. Sarma
title: Ð ÑÑÑÐºÐ°Ñ ÐºÑÐ»ÑÑÑÑÐ° ÐºÐ°Ðº Ð¼ÑÐ³ÐºÐ°Ñ ÑÐ¸Ð»Ð° Ð Ð¾ÑÑÐ¸Ð¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÐÐ¸ÑÐ°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ° Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ 41.04.01 - ÐÐ°ÑÑÐ±ÐµÐ¶Ð½Ð¾Ðµ ÑÐµÐ³Ð¸Ð¾Ð½Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ; 41.04.01_03 - Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ°Ñ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ñ (Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð°Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð°Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð°)
titleType: Subtitle
Creators: name: Ð¯Ð½ Ð¤Ð°Ð½Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¼ÑÐ³ÐºÐ°Ñ ÑÐ¸Ð»Ð°
Ð³ÑÐ¼Ð°Ð½Ð¸ÑÐ°ÑÐ½Ð¾Ðµ ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÑÐµÑÑÐ²Ð¾
ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÑÐµÑÑÐ²Ð¾
Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ðµ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ
Ð½Ð°ÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÐµ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ
ÑÑÑÐ°ÑÐµÐ³Ð¸Ñ
Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÑ
Ð Ð¾ÑÑÐ¸Ñ
ÐÐ¸ÑÐ°Ð¹

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÑÐ°ÑÑÐµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ ÑÑÑÑÐºÐ°Ñ ÐºÑÐ»ÑÑÑÑÐ° ÐºÐ°Ðº Ð¼ÑÐ³ÐºÐ°Ñ ÑÐ¸Ð»Ð° Ð Ð¾ÑÑÐ¸Ð¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÐÐ¸ÑÐ°Ñ. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÑÐ°ÑÑÐµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ Â«Ð ÑÑÑÐºÐ°Ñ ÐºÑÐ»ÑÑÑÑÐ° ÐºÐ°Ðº Ð¼ÑÐ³ÐºÐ°Ñ ÑÐ¸Ð»Ð°Â», ÐµÐµ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÑ Ð¸ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸, Ð¿ÑÐ¸Ð²Ð¾Ð´ÑÑÑÑ Ð½ÐµÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿ÑÐ¸Ð¼ÐµÑÑ ÐµÐµ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð² Ð Ð¾ÑÑÐ¸Ð¸ Ð´Ð»Ñ ÐÐ¸ÑÐ°Ñ. Ð ÑÑÐ°ÑÑÐµ ÑÐ°ÐºÐ¶Ðµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÑÐµÑÑÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¼ÑÐ³ÐºÐ¾Ð¹ ÐºÑÐ»ÑÑÑÑÑ Ð½Ð° ÐºÐ¸ÑÐ°Ð¹ÑÐºÐ¾-ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¸Ðµ Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ. ÐÐµÑÐµÑÐ¸ÑÐ»Ð¸ÑÐµ Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¾Ð±ÑÑÐ¸Ñ Ð¸ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÑÐ¹ÑÐµ ÑÐ¾Ð»Ñ ÑÑÑÑÐºÐ¾Ð¹ ÐºÑÐ»ÑÑÑÑÑ Ð² ÑÑÐ¾Ð¼.
description: This article discusses Russian culture as the soft power of Russia in relation to China. This article dwells upon the concept of âRussian culture as the soft powerâ strategy and its tools and features, gives some examples of its implementation in Russia to China. The article also analyzes the influence of soft culture in China-Russian diplomatic relations. List the diplomatic events and analyze the role of Russian culture in it.
Efficient narrow-band light emission from a single carbon nanotube p-n diode
Creators: name: Mueller, Thomas
name: Kinoshita, Megumi
name: Steiner, Mathias
name: Perebeinos, Vasili
name: Bol, Ageeth A.
name: Farmer, Damon B.
name: Avouris, Phaedon
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Electrically-driven light emission from carbon nanotubes could be exploited in nano-scale lasers and single-photon sources, and has therefore been the focus of much research. However, to date, high electric fields and currents have been either required for electroluminescence, or have been an undesired side effect, leading to high power requirements and low efficiencies. In addition, electroluminescent linewidths have been broad enough to obscure the contributions of individual optical transitions. Here, we report electrically-induced light emission from individual carbon nanotube p-n diodes. A new level of control over electrical carrier injection is achieved, reducing power dissipation by a factor of up to 1000, and resulting in zero threshold current, negligible self-heating, and high carrier-to- photon conversion efficiencies. Moreover, the electroluminescent spectra are significantly narrower (ca. 35 meV) than in previous studies, allowing the identification of emission from free and localized excitons.
Identification of potential Staphylococcus aureus dihydrofolate reductase inhibitors using QSAR, molecular docking, dynamics simulations and free energy calculation
Creators: name: de Araujo Matos, Isaac
name: Pinto, Ana Carolina Goes
name: Ferraz, Matheus Vitor Ferreira
name: Adan, Wenny Camilla Santos
name: Rodrigues, Ricardo Pereira
name: dos Santos, Juliane Xavier
name: Kitagawa, Rodrigo Rezende
name: Lins, Roberto Dias
name: Oliveira, Tiago Branquinho
name: da Costa, Nivan Bezerra
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Herein we describe the use of molecular docking simulations, quantitative structure-activity relationships studies and ADMETox predictions to analyse the molecular recognition of a series of 7-aryl-2,4-diaminoquinazoline derivatives on the inhibition of Staphylococcus aureus dihydrofolate reductase and conducted a virtual screening to discover new potential inhibitors. A quantitative structure-activity relationship model was developed using 40 compounds and two selected descriptors. These descriptors indicated the importance of pKa and molar refractivity for the inhibitory activity against SaDHFR. The values of R2train, CVLOO and R2test generated by the model were 0.808, 0.766, and 0.785, respectively. The integration between QSAR, molecular docking, ADMETox analysis and molecular dynamics simulations with binding free energies calculation, yielded the compounds PC-124127620, PC-124127795 and PC-124127805 as promising candidates to SaDHFR inhibitors. These compounds presented high potency, good pharmacokinetics and toxicological profile. Thus, these molecules are good potential antimicrobial agent to treatment of infect disease caused by S. aureus. Communicated by Ramaswamy H. Sarma
Tunneling Mechanism in Kerr-Newman Black Hole and Dimensional Reduction near the Horizon
Creators: name: Umetsu, Koichiro
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is shown that the derivation of the Hawking radiation from a rotating black hole on the basis of the tunneling mechanism is greatly simplified by using the technique of the dimensional reduction near the horizon. This technique is illustrated for the original derivation by Parikh and Wilczek, but it is readily applied to a variant of the method such as suggested by Banerjee and Majhi.
description: 7 pages
title: Something there badly not wrong: the life and death of literary form in databases
Creators: name: tabbi, joseph
Publisher: name: Electronic Book Review
Year: 2020

description: Returning to his 2010 essay, “Electronic Literature as World Literature,” Tabbi extends those arguments in light of community built scholarly databases that have since emerged and in contrast to an uncritical tracking of “views, citations, downloads and occasional shared themes” (not to mention an increased precarity of authorship, where one’s scholarly work is basically given away). For digital practices to be literary, Tabbi argues, our selections need to circulate within various institutional, academic, curatorial, and cultural structures – each of which is devising its own set of relations to the digital. This essay aims to initiate those ongoing conversations and evaluations in the field of born digital, electronic literature. In so doing, Tabbi suggests how acts of close reading can bring scholars into closer contact with one another and also activate the databases where e-lit archives are presently stored, read, curated, and mined for verbal and perspectival patterns. (Which have been described, in broad outline as a kind of distant reading.)
Discussion of: A statistical analysis of multiple temperature proxies: Are reconstructions of surface temperatures over the last 1000 years reliable?
Creators: name: Craigmile, Peter
name: Rajaratnam, Bala
Publisher: name: arXiv
Year: 2011
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Discussion of "A statistical analysis of multiple temperature proxies: Are reconstructions of surface temperatures over the last 1000 years reliable?" by B.B. McShane and A.J. Wyner [arXiv:1104.4002]
description: Published in at http://dx.doi.org/10.1214/10-AOAS398F the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
A Minimal Inflation Scenario
Creators: name: Alvarez-Gaume, Luis
name: Gomez, Cesar
name: Jimenez, Raul
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We elaborate on a minimal inflation scenario based entirely on the general properties of supersymmetry breaking in supergravity models. We identify the inflaton as the scalar component of the Goldstino superfield. We write plausible candidates for the effective action describing this chiral superfield. In particular the theory depends (apart from parameters of O(1)) on a single free parameter: the scale of supersymmetry breaking. This can be fixed using the amplitude of CMB cosmological perturbations and we therefore obtain the scale of supersymmetry breaking to be 10^{12-14} GeV. The model also incorporates explicit R-symmetry breaking in order to satisfy the slow roll conditions. In our model the eta-problem is solved without extra fine-tuning. We try to obtain as much information as possible in a model independent way using general symmetry properties of the theory's effective action, this leads to a new proposal on how to exit the inflationary phase and reheat the Universe.
description: matches published version (typo corrected)
Molecular insights to the binding interactions of APNS containing HIV-protease inhibitors against SARS-CoV-2 Mpro: an in silico approach towards drug repurposing
Creators: name: Purohit, Priyanka
name: Dash, Jiban Jyoti
name: Muya, Jules Tshishimbi
name: Meher, Biswa Ranjan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: SARS-CoV-2 Mpro is one of the most vital enzymes of the new coronavirus-2 (SARS-CoV-2) and is a crucial target for drug discovery. Unfortunately, there is not any potential drugs available to combat the action of SARS-CoV-2 Mpro. Based on the reports HIV-protease inhibitors can be applied against the SARS by targeting the SARS-CoV-1 Mpro, we have chosen few clinically trialed experimental and allophenylnorstatine (APNS) containing HIV-protease inhibitors (JE-2147, JE-533, KNI-227, KNI-272 & KNI-1931), to examine their binding affinities with SARS-CoV-2 Mpro and to assess their potential to check for a possible drug candidate against the protease. Here, we have chosen a methodology to understand the binding mechanism of these five inhibitors to SARS-CoV-2 Mpro by merging molecular docking, molecular dynamics (MD) simulation and MM-PBSA based free energy calculations. Our estimations disclose that JE-2147 is highly effective (ΔGBind = −28.31 kcal/mol) due to an increased favorable van der Waals (ΔEvdw) interactions and decreased solvation (ΔGsolv) energies between the inhibitor and viral protease. JE-2147 shows a higher level of interactions as compared to JE-533 (−6.85 kcal/mol), KNI-227 (−18.36 kcal/mol), KNI-272 (−15.69 kcal/mol) and KNI-1931 (−21.59 kcal/mol) against SARS-CoV-2 Mpro. Binding contributions of important residues (His41, Met49, Cys145, His164, Met165, Glu166, Pro168, Gln189, etc.) from the active site or near the active site regions with ≥1.0 kcal/mol suggest a potent binding of the inhibitors. It is anticipated that the current study of binding interactions of these APNS containing inhibitors can pitch some valuable insights to design the significantly effective anti-SARS-CoV-2 Mpro drugs. Communicated by Ramaswamy H. Sarma
Chebulinic and chebulagic acid binding with serum proteins: biophysical and molecular docking approach
Creators: name: Yeggoni, Daniel Pushparaju
name: Meti, Manjunath
name: Subramanyam, Rajagopal
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Chebulinic acid (CHN) and chebulagic acid (CHG) have been known for centuries for their anti-cancer, anti-diabetes, HIV and anti-inflammatory properties. In this study, the interaction of these phytochemicals CHN/CHG, with the two major transport proteins for various drugs, human serum albumin (HSA) and α-1-acid glycoprotein (AGP), was unraveled by using several spectroscopic techniques and computational methods. The binding of CHN/CHG quenches the HSA/AGP fluorescence intensities, and also these phytochemicals are bound strongly to HSA/AGP proteins. An apparent decrease in fluorescence intensities of CHN/CHG-HSA and CHN/CHG-AGP complex showed the static mode of fluorescence quenching. Furthermore, the intrinsic fluorescence and using site-specific markers ibuprofen competing with these molecules, thereby replacing it in the binding site of subdomain IIIA. The computational methods substantiated the experimental findings, revealing that CHN interacted with Lys414A, Glu492A, Glu492A and Lys413A residues of subdomain IIIA of HSA and for CHG showed the interaction with Lys545A and Lys413A residues of subdomain IIIA of HSA. Fluorescence and surface plasmon resonance data unveiled a previously unreported binding event between CHN/CHG and HSA; the determined binding affinities of both compounds were slightly higher for HSA than AGP. A change in functionality of protein confirmed the esterase‐like activity of HSA in the presence of CHG/CHN upon binding with CHG/CHN. Displacement and circular dichroism (CD) experiments analysis showed that the two CHN/CHG and binding specifically to IIIA subdomain on HSA results in the conformational changes in the HSA. Thus, CD revealed a few conformational changes in HSA due to CHN/CHG. The binding of these two phytochemicals to the plasma proteins would give a path to develop new inspired drug molecules for chronic diseases. Communicated by Ramaswamy H. Sarma
Discussion of: A statistical analysis of multiple temperature proxies: Are reconstructions of surface temperatures over the last 1000 years reliable?
Creators: name: Wahl, Eugene R.
name: Ammann, Caspar M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Applications (stat.AP)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Discussion of "A statistical analysis of multiple temperature proxies: Are reconstructions of surface temperatures over the last 1000 years reliable?" by B.B. McShane and A.J. Wyner [arXiv:1104.4002]
description: Published in at http://dx.doi.org/10.1214/10-AOAS398J the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
High throughput in silico discovery of antimicrobial peptides in amphibian and insect transcriptomes
Creators: name: Lin, Diana
Publisher: name: University of British Columbia
Year: 2022

description: Antimicrobial peptides (AMPs) are a family of short defence proteins produced naturally by all multicellular organisms, varying from microorganisms to humans. Since resistance to AMPs is less frequent as to antibiotics, they may serve as a potential alternative. Past research has shown that amphibians have the richest known AMP diversity, specifically the North American bullfrog has demonstrated potential in aiding the discovery of novel putative AMPs. Antibiotic resistance is becoming more prevalent each day, requiring agricultural practices to reduce the use of antibiotics to protect human health, animal health, and food safety. To reduce the use of antibiotics, the goal of my thesis is to develop and execute an AMP discovery pipeline to discover AMPs suitable for pharmaceutical development. In this thesis, I have accomplished rAMPage: Rapid Antimicrobial Peptide Annotation and Gene Estimation. rAMPage is a scalable, high throughput bioinformatics-based discovery platform for mining AMP sequences in publicly available genomic resources. RNA-seq amphibian and insect reads from the Sequence Read Archive (SRA) are used. After trimming, reads are assembled with RNA-Bloom into transcripts, filtered, and translated in silico. Then, the translated protein sequences are compared to known AMP sequences from the NCBI protein database and specific AMP databases APD3 and DADP, via homology search. These sequences are cleaved into their mature/bioactive form. Next, machine learning algorithm AMPlify is employed to classify and prioritize the candidate AMPs based on their AMP probability score. Finally, these candidate AMPs are annotated and characterized. Across 84 datasets, rAMPage detected > 1,000 putative AMPs, where 90 sequences have been selected for downstream validation.
Kinks, extra dimensions, and gravitational waves
Creators: name: O'Callaghan, Eimear
name: Gregory, Ruth
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate in detail the gravitational wave signal from kinks on cosmic (super)strings, including the kinematical effects from the internal extra dimensions. We find that the signal is suppressed, however, the effect is less significant that that for cusps. Combined with the greater incidence of kinks on (super)strings, it is likely that the kink signal offers the better chance for detection of cosmic (super)strings.
description: 18 pages, 5 figures
The complexity of flood-filling games on graphs
Creators: name: Meeks, Kitty
name: Scott, Alexander
Publisher: name: arXiv
Year: 2011
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: We consider the complexity of problems related to the combinatorial game Free-Flood-It, in which players aim to make a coloured graph monochromatic with the minimum possible number of flooding operations. Although computing the minimum number of moves required to flood an arbitrary graph is known to be NP-hard, we demonstrate a polynomial time algorithm to compute the minimum number of moves required to link each pair of vertices. We apply this result to compute in polynomial time the minimum number of moves required to flood a path, and an additive approximation to this quantity for an arbitrary k x n board, coloured with a bounded number of colours, for any fixed k. On the other hand, we show that, for k>=3, determining the minimum number of moves required to flood a k x n board coloured with at least four colours remains NP-hard.
description: More typos corrected!
3β-Acetoxy-21α-H-hop-22(29)ene, a novel multitargeted phytocompound against SARS-CoV-2: in silico screening
Creators: name: Siddique, Simna
name: Kumar, R. Pradeep
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The present pandemic disease COVID-19 demands an urgent need for more efficient antiviral drugs against SARS-CoV-2. Computational drug designing and discovery enable us to explore ethnomedicinal plants as a source of various lead molecules that can be used against present and future pathogens. Adiantum latifolium Lam., a common fern, is resistant to pathogens mainly due to the presence of various phytochemicals having antimicrobial properties. In our previous study, 3β-acetoxy-21α-H-hop-22(29)ene, a terpenoid has been characterized from the methanol extract of leaves of A. latifolium. The manuscript evaluates the antiviral potency of the compound against SARS-CoV-2 through molecular docking method. Proteins essential for SARS-CoV-2 multiplication in host cells are the target sites. The study revealed strong binding affinity of the compound for all the ten proteins selected, including seven nonstructural proteins, two structural proteins and one receptor protein, with a binding energy of −4.67 to −8.76 kcal/mol. MDS and MMPBSA analysis of the best ranked complex further confirmed the results. The multitargeted compound can be considered as a natural lead molecule in drug designing against COVID-19, but requires wet-lab experimentation and clinical trials. Communicated by Ramaswamy H. Sarma
New observations concerning the Szeletian in Moravia
Creators: name: Škrdla, Petr
name: Nejman, Ladislav
name: Rychtaříková, Tereza
name: Nikolajev, Pavel
name: Lisá, Lenka
Publisher: name: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit
Year: 2021

description: Quartär – Internationales Jahrbuch zur Erforschung des Eiszeitalters und der Steinzeit, Bd. 61 (2014): Quartär. Internationales Jahrbuch zur Eiszeitalter- und Steinzeitforschung
Accretion onto black holes formed by direct collapse
Creators: name: Johnson, Jarrett L.
name: Khochfar, Sadegh
name: Greif, Thomas H.
name: Durier, Fabrice
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: One possible scenario for the formation of massive black holes (BHs) in the early Universe is from the direct collapse of primordial gas in atomic-cooling dark matter haloes in which the gas is unable to cool efficiently via molecular transitions. We study the formation of such BHs, as well as the accretion of gas onto these objects and the high energy radiation emitted in the accretion process, by carrying out cosmological radiation hydrodynamics simulations. In the absence of radiative feedback, we find an upper limit to the accretion rate onto the central object which forms from the initial collapse of hot (~ 10^4 K) gas of the order of 0.1 MSun per year. This is high enough for the formation of a supermassive star, the immediate precursor of a BH, with a mass of the order of 10^5 MSun. Assuming that a fraction of this mass goes into a BH, we track the subsequent accretion of gas onto the BH self-consistently with the high energy radiation emitted from the accretion disk. Using a ray-tracing algorithm to follow the propagation of ionizing radiation, we model in detail the evolution of the photoionized region which forms around the accreting BH. We find that BHs with masses of the order of 10^4 MSun initially accrete at close to the Eddington limit, but that the accretion rate drops to of order 1 percent of the Eddington limit after ~ 10^6 yr, due to the expansion of the gas near the BH in response to strong photoheating and radiation pressure. One signature of the accretion of gas onto BHs formed by direct collapse, as opposed to massive Pop III star formation, is an extremely high ratio of the luminosity emitted in He II 1640 to that emitted in H_alpha (or Ly_alpha); this could be detected by the James Webb Space Telescope. Finally, we briefly discuss implications for the coevolution of BHs and their host galaxies.
description: 16 pages; 17 figures, slightly reduced quality; MNRAS in press
Renormalized Vacuum Polarization and Stress Tensor on the Horizon of a Schwarzschild Black Hole Threaded by a Cosmic String
Creators: name: Ottewill, Adrian C.
name: Taylor, Peter
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We calculate the renormalized vacuum polarization and stress tensor for a massless, arbitrarily coupled scalar field in the Hartle-Hawking vacuum state on the horizon of a Schwarzschild black hole threaded by an infinte straight cosmic string. This calculation relies on a generalized Heine identity for non-integer Legendre functions which we derive without using specific properties of the Legendre functions themselves.
description: This is an expanded version of a previous submission, we have added the calculation of the stress tensor. 28 pages, 7 figures
Functional and biochemical characterization of novel genetic variants in IRAK4 and IRF4 causing human inborn errors of immunity
Creators: name: Jia, Alicia
Publisher: name: University of British Columbia
Year: 2023

description: Human inborn errors of immunity (IEIs) are a group of genetic disorders in which specific components of the human immune system are missing, dysfunctional, or poorly regulated. IEIs negatively impact the protective functions of the immune system, increasing susceptibility to infections, autoimmunity, inflammation, and malignancy. The investigation of monogenic IEIs enables the diagnosis and treatment of the affected individuals and provides unique opportunities to understand the role of the immune system and the functional roles of its constituents. Toll-like receptor (TLR) signaling is a key aspect of the innate immune response, and interleukin-1 receptor-associated kinase 4 (IRAK4) plays a vital role in the TLR signaling cascade which enables the production of protective inflammatory cytokines. Human IRAK4-deficiency is an autosomal recessive IEI which presents with a blunted inflammatory response to infection and susceptibility to certain bacteria. We demonstrate that the novel IRAK4 (c.1049delG, p.(Gly350Glufs*15)) variant abrogates IRAK4 protein expression and abolishes TLR signaling, expanding the knowledge of pathogenic variants causing human IRAK4-deficiency. We have also identified 3 unrelated individuals with a phenotype of combined immunodeficiency (agammaglobulinemia and infectious susceptibility) who carry a novel heterozygous de novo missense variant in Interferon Regulatory Factor 4 (IRF4) gene (c.284C>G, p.T95R). IRF4 is a transcription factor expressed in immune cells which plays a critical role in the differentiation of various immune cells. We demonstrate adaptive immune cell differentiation defects in proband primary cells, as well as decreased effector cytokine production in T cells. We also demonstrate that the IRF4 T95R variant is able to bind the canonical GAAA binding site as well as a novel GATA binding site. Therefore, we propose that the IRF4 T95R variant is defined as a neomorphic variant, as it has gained novel DNA-binding functions. This increase in DNA-binding sequence promiscuity may result in a dominant negative redistribution of the wild-type IRF4 and the combined immunodeficiency phenotype in the proband. We have characterized a novel neomorphic variant in the IRF4 gene and defined a novel human IEI which highlights the potential of IRF4 as an immunomodulatory therapeutic target.
Projective Limit Random Probabilities on Polish Spaces
Creators: name: Orbanz, Peter
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistics Theory (math.ST)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: A pivotal problem in Bayesian nonparametrics is the construction of prior distributions on the space M(V) of probability measures on a given domain V. In principle, such distributions on the infinite-dimensional space M(V) can be constructed from their finite-dimensional marginals---the most prominent example being the construction of the Dirichlet process from finite-dimensional Dirichlet distributions. This approach is both intuitive and applicable to the construction of arbitrary distributions on M(V), but also hamstrung by a number of technical difficulties. We show how these difficulties can be resolved if the domain V is a Polish topological space, and give a representation theorem directly applicable to the construction of any probability distribution on M(V) whose first moment measure is well-defined. The proof draws on a projective limit theorem of Bochner, and on properties of set functions on Polish spaces to establish countable additivity of the resulting random probabilities.
description: 20 pages, 3 figures. Published in the Electronic Journal of Statistics by the Institute of Mathematical Statistics
Additional file 1 of Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration
Creators: name: Wang, Jijing
name: Zhang, Ya-Ru
name: Shen, Xue-Ning
name: Han, Jinming
name: Cui, Mei
name: Tan, Lan
name: Dong, Qiang
name: Zubarev, Roman A.
name: Yu, Jin-Tai
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health

description: Additional file 1: Table S1. The regression coefficients (R) between deamidation biomarkers and other indicators.
title: ÐÐ¾Ð»Ð½Ð¾Ð¼Ð¾ÑÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð²Ð»Ð°ÑÑÐ¸ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐ¾Ð¼Ð½Ð¾Ð¹ ÑÐ½ÐµÑÐ³Ð¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Powers of authorities in the field of atomic energy use
Creators: name: ÐÐ°Ð²ÑÑÐ»Ð¾Ð²Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ð°ÑÐ¾Ð¼Ð½Ð°Ñ ÑÐ½ÐµÑÐ³Ð¸Ñ
Ð¿ÑÐ°Ð²Ð¾Ð²Ð¾Ðµ ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
Ð¿Ð¾Ð»Ð½Ð¾Ð¼Ð¾ÑÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð²Ð»Ð°ÑÑÐ¸
nuclear energy
legal regulation
authorities ' powers

description: ÐÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐµÐ¼Ðµ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¿Ð¾Ð»Ð½Ð¾Ð¼Ð¾ÑÐ¸Ð¹ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð²Ð»Ð°ÑÑÐ¸ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐ¾Ð¼Ð½Ð¾Ð¹ ÑÐ½ÐµÑÐ³Ð¸Ð¸. ÐÐ·ÑÑÐµÐ½Ñ Ð¸ÑÑÐ¾ÑÐ¸ÐºÐ¾-Ð¿ÑÐ°Ð²Ð¾Ð²ÑÐµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¿ÑÐ°Ð²Ð¾Ð²Ð¾Ð³Ð¾ ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐ¾Ð¼Ð½Ð¾Ð¹ ÑÐ½ÐµÑÐ³Ð¸Ð¸, ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ñ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¸ ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ, Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐµ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð°ÑÐ¾Ð¼Ð½Ð¾Ð¹ ÑÐ½ÐµÑÐ³Ð¸Ð¸ Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð¿ÑÑÐ¸ Ð¸Ñ ÑÐµÑÐµÐ½Ð¸Ñ.
description: The final qualification work is devoted to the topic of studying the powers of the authorities in the field of nuclear energy use. The historical and legal features of the development of the legal regulation of the use of atomic energy are studied, the fundamentals of state administration and regulation are considered, the actual problems in the field of the use of atomic energy are identified and the ways of their solution are proposed.