cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adverse events associated with inclisiran: a real-world disproportionality analysis based on the FAERS database
Creators: name: Cai, Xuyang
name: Peng, Shaopeng
name: Mu, Shangzhen
name: Lei, Song
name: Li, Juan
name: Tang, Xiaoxue
name: Qiu, Feng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Randomized clinical trials have reported some safety profiles in inclisiran, but adverse events in real-world remain insufficient. We aim to detect the safety of inclisiran in real-world by collecting the data from the FDA Adverse Event Reporting System database. Disproportionality analysis was performed by utilizing both Frequency method and Bayesian method to mine adverse event signals of inclisiran. A positive signal was deemed significant when adverse event met the criteria of the aforementioned methods simultaneously. We gathered a total of 2309 adverse event reports. Among these cases, adverse events were more common in females and ≥ 65 age group. After data analysis, 51 positive signals from 11 system organ classes were identified, involving ‘Musculoskeletal and connective tissue disorders,’ ‘General disorders and administration site conditions,’ ‘Gastrointestinal disorders,’ etc. At the preferred term level, the top three most frequent adverse events were arthralgia, injection site pain and myalgia. We also found some uncommon but significantly strong adverse event signals (bladder discomfort and sinus pain) which should be taken prudently. In this study, we analyzed the real-world adverse events of inclisiran more comprehensively and reported some new adverse events, hoping that can offer more safety information for clinical medication.
Additional file 3 of Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation
Creators: name: Luo, Chen
name: Yu, Yi
name: Zhu, Jinfeng
name: Chen, Leifeng
name: Li, Dan
name: Peng, Xingyu
name: Liu, Zitao
name: Li, Qing
name: Cao, Qing
name: Huang, Kai
name: Yuan, Rongfa
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 3
Nephrotoxicity risks of colistin-combination therapy: a USFDA adverse event reporting system analysis using disproportionality and interaction assessment
Creators: name: Sridharan, Kannan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Colistin, a last-resort antimicrobial, is often used in combination with other drugs to treat multidrug-resistant infections, but its nephrotoxic potential raises concerns, especially in combination therapies. A retrospective analysis was performed on 29,163,222 reports from the USFDA Adverse Event Reporting System (AERS), identifying 125 reports meeting inclusion criteria for acute renal failure (ARF) associated with colistin-antimicrobial combinations. Disproportionality analysis using frequentists and Bayesian techniques were employed to evaluate ARF risk. Drug interaction and clinical outcomes were assessed using the Interaction-Adjusted SignalScores (INTSS) and mortality data, respectively. The results showed significantly higher ARF risk for colistin combinations with ceftazidime, vancomycin, meropenem, and tigecycline, with particularly strong signals observed for colistin-ceftazidime combinations, corroborated by INTSS. Mortality rates were paradoxically higher in patients receiving colistin without nephrotoxic antimicrobials. Comprehensive signal detection metrics highlighted a consistent ARF risk for several other antimicrobial combinations. Clinical outcomes analysis revealed a complex relationship between combination therapy choices and patient mortality. Colistin combinations with certain antimicrobials, especially ceftazidime, vancomycin, and tigecycline, carry significantly higher nephrotoxicity risks, warranting careful clinical consideration. Rigorous renal monitoring protocols are essential in managing these therapies, particularly in critically ill patients.
Functionalized stober silica as a support in immobilization process of lipase from Candida Rugosa
Creators: name: Kolodziejczak-Radzimska, Agnieszka
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: Candida rugosa
functionalized Stober silica
immobilization process
hydrolytic activity

description: Physicochemical Problems of Mineral Processing; ISSN 2084-4735
Chloride leaching of silver and lead from a solid residue after atmospheric leaching of flotation copper concentrates
Creators: name: Chmielewski, Tomasz
name: Gibas, Krzysztof
name: Borowski, Kamil
name: Adamski, Zbigniew
name: Wozniak, Barbara
name: Muszer, Antoni
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: copper concentrate
atmospheric leaching
chloride leaching
silver
lead

description: Physicochemical Problems of Mineral Processing; ISSN 2084-4735
Daspos - Data And Software Preservation
Creators: name: Watts, Gordon
Publisher: name: Zenodo
Year: 2017
Subjects: DASPOS
Data Preservation
Software Preservation

description: A talk discussing the results of the DASPOS effort, a grant designed to explore data and software preservation in experimental particle physics. Given to an audience of experimental Nuclear physicists, as they are looking at how to approach software in the larger collaborations they are currently together for the next generation of experiments.

Given for the DASPOS collaboration.
sj-pdf-1-bbi-10.1177_11779322211030364 – Supplemental material for DEELIG: A Deep Learning Approach to Predict Protein-Ligand Binding Affinity
Creators: name: Ahmed, Asad
name: Mam, Bhavika
name: Sowdhamini, Ramanathan
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-pdf-1-bbi-10.1177_11779322211030364 for DEELIG: A Deep Learning Approach to Predict Protein-Ligand Binding Affinity by Asad Ahmed, Bhavika Mam and Ramanathan Sowdhamini in Bioinformatics and Biology Insights
Concomitant use of sodium-glucose co-transporter 2 inhibitors and metformin and the risk of osteomyelitis reporting: a disproportionality analysis based on FAERS database
Creators: name: Wu, Jiangfan
name: Wang, Xin
name: Zhao, Xiaofang
name: Zhu, Shenyin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Recent clinical case reports have generated controversy concerning the adverse events (AEs) of amputation linked to sodium-glucose co-transporter 2 inhibitors (SGLT2i). We assessed the risk of osteomyelitis AE reporting linked to SGLT2i or SGLT2i-metformin co-medication. Investigated the FDA Adverse Event Reporting System for osteomyelitis-related AEs associated with SGLT2i or SGLT2i-metformin co-medication from 2013q2 to 2023q1. Comprehensive disproportionality analysis and Bayesian confidence propagation methods were used to detect safe signals. The additive interaction model, multiplicative interaction model, and Ω shrinkage measure were employed to explore the latent interactions between SGLT2i and metformin. A Venn diagram was utilized to estimate the coincidence of related osteomyelitis and amputation. Among 2,569 SGLT2i-associated osteomyelitis reports, we identified 2,509 related to canagliflozin (ROR 104.47; PRR 99.70, χ2 = 214840.90; EBGM05 = 84.38; IC025 = 4.78) and 103 related to the SGLT2i-metformin compound. Drug-drug interaction detection revealed a negative correlation RERI = −21.73, eβ3 = 0.699, Ω025=−1.370). The coincidence of osteomyelitis and amputation linked to SGLT2i (2,672 vs. 3,548) was 2,150(80%) by Venn diagram. This study showed an increased risk of SGLT2i-associated osteomyelitis, focusing on canagliflozin, and presented a potential association between amputation and osteomyelitis, providing a reference for the clinical practice of diabetes with SGLT2i medication.
The Grit-to-Graduate: Pedagogical Ideas for Fostering College Persistence, Academic Success, and Career Readiness in Freshmen Through the Basic Communication Course
Creators: name: Bleed, Lynette J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Higher education

description: Students who achieve their long-term goal of graduating from college are models of persistence and grit. Grit is the self-regulatory construct defined as “passion and perseverance for long-term goals despite setbacks, failures, and competing pursuits” (Eskreis-Winkler, Gross, Duckworth, 2016) and has been associated with both academic and workplace success (Eskreis-Winkler, Duckworth, Shulman, & Beal, 2014). Unfortunately, 37% of freshmen drop out of college by the end of their freshmen year (Almeida, 2016; Snyder, de Brey, & Dillow, 2018). The college classroom provides an optimal environment for institutions of higher learning to foster the grit-to-graduate in college freshmen, to enhance learning and academic success, and to increase goal commitment to graduation, degree achievement, and career readiness. The purpose of this study was to investigate whether six pedagogical interventions and project adaptations would increase student grit in an entry-level communication class heavily comprised of freshmen. Four class sections were administered the 12-item grit scale (Duckworth, 2019) during the first and last week of first semester at a Midwestern University (N=79). The experimental group received the pedagogical grit interventions throughout the semester; the control group did not. A repeated measures ANOVA computed the variance of grit scores between the groups. Students in the experimental group also provided quantitative and qualitative data about which pedagogical instruments they found most effective. While the hypothesis was not supported, student feedback on the six grit interventions was largely positive. Ideas for improving the interventions and for fostering grit and college persistence in freshmen are included.
Die Gesundheit arbeitsloser Frauen und Männer - Erste Auswertungen des telefonischen Gesundheitssurveys 2003
Creators: name: Lange, Cornelia
name: Lampert, Thomas
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2005
Subjects: subject: Arbeitslosigkeit
subject: Telefonischer Gesundheitssurvey 2003
subject: Subjektive Gesundheit
subject: Geschlechtsspezifische Gesundheitsunterschiede
subject: Subjective health
subject: Telephone Health Survey 2003
subject: Unemployment
subject: Gender-specific health differences
subject: 610 Medizin

description: Arbeitslosigkeit geht mit materiellen und psychosozialen Folgen einher, die sich auch auf die Gesundheit auswirken können. Nach den Daten des telefonischen Gesundheitssurveys 2003 (GSTel03) sind arbeitslose Frauen und Männer von vielen Krankheiten und Beschwerden häufiger betroffen, sie schätzen ihre eigene Gesundheit schlechter ein und geben vermehrt an, in der gesundheitsbezogenen Lebensqualität eingeschränkt zu sein. Bei Männern lassen sich Gesundheitsprobleme vor allem bei Langzeitarbeitslosigkeit (>1 Jahr) beobachten, während bei Frauen kurzzeitige Arbeitslosigkeitserfahrungen ebenso oder sogar noch weitreichendere Konsequenzen für die Gesundheit haben. Andererseits liefert die Analyse deutliche Hinweise darauf, dass eine beeinträchtigte Gesundheit ein Risiko für Arbeitslosigkeit darstellt. Abschließend beantworten lässt sich die Frage nach der Kausalrichtung zwischen Arbeitslosigkeit und Gesundheit allerdings nicht, da hierzu Längsschnittdaten erforderlich sind.
description: Unemployment has material and psychosocial consequences that can also have an adverse effect on health. According to the Telephone Health Survey 2003, unemployed women and men suffer more frequently from many diseases and complaints. Their assessment of their own state of health is also more negative, and they say more often that their quality of life is restricted by their health. In the case of men, health problems are especially common among the long-term unemployed (>1 year), whereas women can suffer equally (or even more) serious effects on their health as a result of short-term unemployment. On the other hand, the analysis clearly indicates that poor health heightens a personrsquos risk of becoming unemployed. However, no conclusive statement can be made on the direction of causality between unemployment and health, since this requires more longitudinal data.
Additional file 7 of DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation
Creators: name: Gómez, Rodolfo
name: Barter, Matt J.
name: Alonso-Pérez, Ana
name: Skelton, Andrew J.
name: Proctor, Carole
name: Herrero-Beaumont, Gabriel
name: Young, David A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7: Figure S2. Output of ingenuity pathway analysis. Representation of the significant enrichment on ‘inhibition of MMPs’ as well as ‘WNT pathway activation’.
title: Zum Adelsstudium an der Universität Jena in der frühen Neuzeit, 1548-1699. Frequenz, regionaler Einzugsbereich und soziale Zusammensetzung
Creators: name: Mutschler, Thomas
Publisher: name: Friedrich-Schiller-Universität
Year: 2025
Subjects: subject: Adel
subject: 943

description: Untersucht wird die Bedeutung des Adelsstudiums für die Universität Jena im Zeitraum von 1548 bis 1699. Die Arbeit basiert auf einer Analyse der Jenaer Universitätsmatrikel. Der Anteil des Adels an der Universität Jena betrug im Durchschnitt 6,3 Prozent. Die Adelsfrequenz schwankte im Laufe der Zeit erheblich. Ihre erste Hochphase erreichte das Adelsstudium an der Universität Jena zu Beginn des 17. Jahrhunderts, als der Anteil adeliger Studenten am gesamten Besucheraufkommen in Jena auf über 11 Prozent kletterte. Ab 1620 ging die Zahl der Immatrikulationen aufgrund des Dreißigjährigen Krieges stark zurück. Analysiert werden ferner der regionale Einzugsbereich sowie der Sozialstatus der an der Universität Jena eingeschriebenen Adelsstudenten. Die meisten adeligen Studenten kamen aus dem thüringisch-sächsischen Raum. Der Anteil auswärtiger Adeliger stieg im Laufe der Zeit an. Am Ende des 17. Jahrhunderts kamen mehr als die Hälfte der adeligen Studenten aus anderen Regionen. Die meisten adeligen Studenten stammten aus dem niederen Adel. Der Anteil des Hochadels an der adeligen Besucherschaft der Universität Jena betrug im Untersuchungszeitraum durchschnittlich 6,2 Prozent. Die Universität Jena war im 16. und 17. Jahrhundert ein attraktiver Studienort für Adelige aus verschiedenen Regionen.
Additional file 1 of An analysis of published study designs in PubMed prisoner health abstracts from 1963 to 2023: a text mining study
Creators: name: Karystianis, George
name: Lukmanjaya, Wilson
name: Buchan, Iain
name: Simpson, Paul
name: Ginnivan, Natasha
name: Nenadic, Goran
name: Butler, Tony
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Moral Challenge and Narrative Structure: Fairy Chaos in Middle English Romance
Creators: name: McKee, Arielle C
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: British and Irish literature

description: Medieval fairies are chaotic and perplexing narrative agents—neither humans nor monsters—and their actions are defined only by a characteristic unpredictability. My dissertation investigates this fairy chaos, focusing on those moments in a premodern romance when a fairy or group of fairies intrudes on a human community and, to be blunt, makes a mess. I argue that fairy disruption of human ways of thinking and being—everything from human corporeality to the definition of chivalry—is often productive or generative. Each chapter examines how narrative fairies upset medieval English culture’s operations and rules (including, frequently, the rules of the narrative itself) in order to question those conventions in the extra-narrative world of the tale’s audience. Fairy romances, I contend, puzzle and engage their audiences, encouraging readers and hearers to think about and even challenge the processes of their own society. In this way, my research explores the interaction between a text and its audience—between fiction and reality—illuminating the ways in which premodern narratives of chaos and disruption encourage readers and headers to engage in a sustained, ethical consideration of the world.
Is low birth weight in the causal pathway of the association between maternal smoking in pregnancy and higher BMI in the offspring?
Creators: name: Beyerlein, Andreas
name: Rückinger, Simon
name: Toschke, André Michael
name: Rosario, Angelika Schaffrath
name: Kries, Rüdiger Von
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2011
Subjects: subject: Obesity
subject: Smoking
subject: Body mass index
subject: Overweight
subject: KiGGS
subject: Birth weight
subject: 610 Medizin

description: A number of cross-sectional and prospective studies suggested a priming effect of maternal smoking in pregnancy on offspring’s obesity. It has been hypothesized that this association might be explained by low birth weight and subsequent catch-up growth in the causal pathway. We therefore examined the role of birth weight in children exposed versus not exposed to cigarette smoking in utero on later body mass index (BMI). Using data of 12,383 children and adolescents (3–17 years of age) recorded in a German population-based survey (KiGGS), we assessed mean body mass index standard deviation scores (BMI-SDS) in different birth weight SDS categories, stratified for children with smoking and non-smoking mothers. We calculated spline regression models with BMI-SDS as outcome variable, cubic splines of birth weight SDS, and potential confounding factors. Children whose mothers had been smoking during pregnancy had lower birth weight SDS and higher BMI-SDS at interview compared to children of non-smoking mothers. However, we observed a linear association between birth weight SDS and BMI-SDS in crude analyses for both groups. Similarly, almost linear effects were observed in adjusted spline regression analyses, except for children with very low birth weight. The respective 95% confidence bands did not preclude a linear effect for the whole birth weight SDS distribution. Our findings suggest that low birth weight is unlikely to be the main cause for the association between intrauterine nicotine exposure and higher BMI in later life. Alternative mechanisms, such as alterations in the noradrenergic system or increased food efficiency, have to be considered.
Cardiovascular adverse events associated with PARP inhibitors for ovarian cancer: a real world study (RWS) with Bayesian disproportional analysis based on the FDA adverse event reporting system (FAERS)
Creators: name: Yang, Chenguang
name: Song, Xuan
name: Sun, Hongmei
name: Chen, Xi
name: Liu, Chengjiang
name: Chen, Min
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: To investigate the pharmacovigilance (PV) and make pairwise comparisons on reporting proportion, seriousness, and severity of outcomes of major adverse cardiovascular events (MACE) among poly(ADP-ribose) polymerase-inhibitors (PARPis) in treating ovarian cancer, fallopian tube carcinoma, and primary peritoneal cancer (collectively named EOC) from the US Food and Drug Administration Adverse Event Reporting System (FAERS). Data on adverse cardiovascular events reports related to EOC treatment submitted to FAERS from the first quarter of 2015 to the second quarter of 2023 were harvested. Three PARPis were identified: olaparib, niraparib, and rucaparib. Eventually, a total of 258,596 eligible records were enrolled with 12,331 reports including 5,292 reports of MACE and 7,039 reports of other cardiovascular events. For the primary composite endpoint, a PV signal associated with MACE was detected in niraparib (ROR = 1.12; IC025 = 0.03), whereas it was not detected in olaparib and rucaparib; For the secondary endpoint, PV signals associated with other cardiovascular events were detected in niraparib (ROR = 1.17;IC025 = 0.04), but not in olaparib and rucaparib. For EOC patients, close monitoring of blood pressure, heart rate, and coagulation function should be conducted when selecting niraparib for treatment.
Comparison of adverse events of poly adenosine diphosphate ribose polymerase inhibitors in patients with ovarian cancer using the United States Food and Drug Administration Adverse Event Reporting System
Creators: name: Ogura, Toru
name: Shiraishi, Chihiro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Olaparib, niraparib, and rucaparib are the three primary poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors that are currently available in the market. Previous studies indicate different incidences of adverse events based on the PARP inhibitor or country. This study used data from the United States Food and Drug Administration Adverse Event Reporting System collected between January 2018 and December 2023. The data analyzed in this study involved patients receiving PARP inhibitors for treating ovarian cancer. A comparative analysis of the three PARP inhibitors was conducted using the reporting odds ratio (ROR) and the adjusted ROR (aROR) controlling for patient background differences. The aROR for niraparib was significant at > 1.000, including platelet count decreased (p < 0.001) and thrombocytopenia (p < 0.001) when olaparib was set as the reference. Conversely, the aROR for niraparib was significant at < 1.000, including anemia (p < 0.001). Additionally, significant differences were observed in various adverse events for rucaparib. Moreover, significant differences were observed when comparing between countries. This study indicates that the types of adverse events may vary by PARP inhibitor and by country. These results will be beneficial in clinical practice. Read the transcript Watch the video on Vimeo
sj-pdf-1-jir-10.1177_00221856211025574 - Supplemental material for Bargaining for gender equality in Aotearoa New Zealand: Flexible work arrangements in collective agreements, 2007–2019
Creators: name: Proctor-Thomson, Sarah
name: Donnelly, Noelle
name: Parker, Jane
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-jir-10.1177_00221856211025574 for Bargaining for gender equality in Aotearoa New Zealand: Flexible work arrangements in collective agreements, 2007–2019 by Sarah Proctor-Thomson, Noelle Donnelly and Jane Parker in Journal of Industrial Relations
Additional file 2 of An analysis of published study designs in PubMed prisoner health abstracts from 1963 to 2023: a text mining study
Creators: name: Karystianis, George
name: Lukmanjaya, Wilson
name: Buchan, Iain
name: Simpson, Paul
name: Ginnivan, Natasha
name: Nenadic, Goran
name: Butler, Tony
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 2
Concomitant use of sodium-glucose co-transporter 2 inhibitors and metformin and the risk of osteomyelitis reporting: a disproportionality analysis based on FAERS database
Creators: name: Wu, Jiangfan
name: Wang, Xin
name: Zhao, Xiaofang
name: Zhu, Shenyin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Recent clinical case reports have generated controversy concerning the adverse events (AEs) of amputation linked to sodium-glucose co-transporter 2 inhibitors (SGLT2i). We assessed the risk of osteomyelitis AE reporting linked to SGLT2i or SGLT2i-metformin co-medication. Investigated the FDA Adverse Event Reporting System for osteomyelitis-related AEs associated with SGLT2i or SGLT2i-metformin co-medication from 2013q2 to 2023q1. Comprehensive disproportionality analysis and Bayesian confidence propagation methods were used to detect safe signals. The additive interaction model, multiplicative interaction model, and Ω shrinkage measure were employed to explore the latent interactions between SGLT2i and metformin. A Venn diagram was utilized to estimate the coincidence of related osteomyelitis and amputation. Among 2,569 SGLT2i-associated osteomyelitis reports, we identified 2,509 related to canagliflozin (ROR 104.47; PRR 99.70, χ2 = 214840.90; EBGM05 = 84.38; IC025 = 4.78) and 103 related to the SGLT2i-metformin compound. Drug-drug interaction detection revealed a negative correlation (RERI=-21.73, eβ3 = 0.699, Ω025=-1.370). The coincidence of osteomyelitis and amputation linked to SGLT2i（2,672 vs. 3,548）was 2,150(80%) by Venn diagram. This study showed an increased risk of SGLT2i-associated osteomyelitis, focusing on canagliflozin, and presented a potential association between amputation and osteomyelitis, providing a reference for the clinical practice of diabetes with SGLT2i medication.
Incidence and risk of treatment-related fatal adverse events in cancer patients treated with antibody conjugated drugs: a systematic review and meta-analysis of randomized controlled trials
Creators: name: Huang, Zhaohui
name: Li, Xinyu
name: Zhou, Xin
name: Yang, Ziwen
name: Huo, Xiaotong
name: Zhu, Jianhong
name: Li, Sha
name: Jiang, Jie
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Antibody-drug conjugates (ADCs) have radically transformed the therapeutic landscape for cancer treatment, but little is known about the treatment-related fatal adverse events (FAEs). We aimed to comprehensively investigate the safety of ADCs regarding treatment-related FAEs. We conducted a systematic search of PubMed, Embase, and the Cochrane database for randomized controlled trials (RCTs) of ADCs. The meta-analysis assessed the incidence of treatment-related FAEs and the odds ratio (OR) in the ADCs group compared with the control group. A total of 49 RCTs involving 13,052 patients treated with ADCs were included. The incidence of treatment-related FAEs in the ADCs group was 0.62% (95% CI = 0.36–1.08), while the control group was 0.52% (95% CI = 0.29–0.95), with an OR of 1.41 (95% CI = 1.12–1.79; p < 0.05). In the subgroup analysis by drug and cancer type, gemtuzumab ozogamicin, which for acute myeloid leukemia were associated with a higher risk of treatment-related FAEs compared to controls (OR = 1.63; 95% CI = 1.12–2.36; p < 0.05). There was no evidence of publication bias observed. The meta-analysis of RCTs found that ADCs were associated with an increased risk of treatment-related FAEs compared with the control group. Moreover, the occurrence of treatment-related FAEs was associated with specific types of ADCs.
Incidence and risk of treatment-related fatal adverse events in cancer patients treated with antibody conjugated drugs: a systematic review and meta-analysis of randomized controlled trails
Creators: name: Huang, Zhaohui
name: Li, Xinyu
name: Zhou, Xin
name: Yang, Ziwen
name: Huo, Xiaotong
name: Zhu, Jianhong
name: Li, Sha
name: Jiang, Jie
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Antibody-drug conjugates (ADCs) have radically transformed the therapeutic landscape for cancer treatment, but little is known about the treatment-related fatal adverse events (FAEs). We aimed to comprehensively investigate the safety of ADCs regarding treatment-related FAEs. We conducted a systematic search of PubMed, Embase, and the Cochrane database for randomized controlled trials (RCTs) of ADCs. The meta-analysis assessed the incidence of treatment-related FAEs and the odds ratio (OR) in the ADCs group compared with the control group. A total of 49 RCTs involving 13,052 patients treated with ADCs were included. The incidence of treatment-related FAEs in the ADCs group was 0.62% (95% CI = 0.36-1.08), while the control group was 0.52% (95% CI = 0.29-0.95)，with an OR of 1.41 (95% CI = 1.12-1.79; p < 0.05). In the subgroup analysis by drug and cancer type, gemtuzumab ozogamicin, which for acute myeloid leukemia were associated with a higher risk of treatment-related FAEs compared to controls (OR = 1.63; 95% CI = 1.12-2.36; p < 0.05). There was no evidence of publication bias observed. The meta-analysis of RCTs found that ADCs were associated with an increased risk of treatment-related FAEs compared with the control group. Moreover, the occurrence of treatment-related FAEs was associated with specific types of ADCs.
THE INFLUENCE OF PATIENT RACE, PATIENT GENDER, AND PROVIDER PAIN-RELATED ATTITUDES ON PAIN ASSESSMENT AND TREATMENT RECOMMENDATIONS FOR CHILDREN WITH PAIN
Creators: name: Miller, Megan Marie
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Clinical psychology

description: Chronic pain is a common and costly health condition for children. Previous studies have documented racial and gender disparities in pain care for adults, with women and racial minorities receiving poorer pain assessment and treatment. Providers contribute to these disparities when their pain-related decision-making systematically varies across patient demographic groups. Little is known about racial and gender disparities in children with chronic pain, or the extent to which providers contribute to these disparities. In a sample of 129 medical students (henceforth referred to as ‘providers’), Virtual Human (VH) methodology and a pain-related version of the Implicit Association Test (IAT) were used to assess the effects of patient race/gender and provider implicit racial/gender attitudes on providers’ pain assessment and treatment decisions for children with chronic pain. Findings indicated that, in the context of abdominal pain, providers rated Black patients as more distressed (mean difference [MD]=2.33, p.05). The sample reported implicit attitudes that men and Black Americans were more pain-tolerant than their demographic counterparts; however, pain assessment and treatment decisions were not related to these implicit attitudes. This study represents a critical step in research on pain-related disparities in pediatric pain. Future studies are needed to further elucidate specific paths through which the pain experience and consequent treatment differ across racial and gender groups.
Under-recognition and reporting of dengue in Cambodia: a capture–recapture analysis of the National Dengue Surveillance System
Creators: name: Vong, S.
name: Goyet, S.
name: Ngan, C.
name: Huy, R.
name: Ly, S.
name: Wichmann, Ole
name: Letson, G. W.
name: Margolis, H. S.
name: Buchy, P.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2011
Subjects: subject: Active surveillance
subject: Cambodia
subject: capture–recapture
subject: cohort
subject: dengue
subject: national surveillance
subject: underreporting
subject: 610 Medizin

description: Robust disease burden estimates are important for decision-making concerning introduction of new vaccines. Dengue is a major public health problem in the tropics but robust disease burden estimates are lacking. We conducted a two-sample, capture–recapture study in the largest province in Cambodia to determine disease under-recognition to the National Dengue Surveillance System (NDSS). During 2006–2008, community-based active surveillance for acute febrile illness was conducted in 0- to 19-year-olds in rural and urban areas combined with testing for dengue virus infection. Of 14 354 individuals under active surveillance (22 498 person-seasons), the annual incidence ranged from 13·4 to 57·8/1000 person-seasons. During the same period, NDSS incidence rates ranged from 1·1/1000 to 5·7/1000, which was 3·9- to 29·0-fold lower than found in the capture–recapture study. In hospitalized cases, the rate of under-recognition was 1·1- to 2·4-fold. This study shows the substantial degree of under-recognition/reporting of dengue and that reported hospitalized cases are not a good surrogate for estimating dengue disease burden.
Additional file 2 of Barriers and facilitators of older adults for professional mental health help-seeking: a systematic review
Creators: name: Elshaikh, Usra
name: Sheik, Rayan
name: Saeed, Raghad Khaled Mohammad
name: Chivese, Tawanda
name: Alsayed Hassan, Diana
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Additional file 2. Detailed search strategy used to identify relevant studies.
Hypogammaglobulinemia in patients with multiple sclerosis receiving disease modifying therapies: disproportionality analysis using the EudraVigilance database
Creators: name: Di Napoli, Raffaella
name: Balzano, Nunzia
name: Rafaniello, Concetta
name: Della Monica, Paola
name: Di Domenico, Marina
name: Di Giulio Cesare, Daniele
name: Maniscalco, Giorgia Teresa
name: Scavone, Cristina
name: Trama, Ugo
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Monoclonal antibodies targeting CD20, such as rituximab, ocrelizumab, and ofatumumab, are crucial in managing multiple sclerosis (MS). However, they can cause hypogammaglobulinemia, increasing the risk of infections and autoimmune disorders. This study describes cases of hypogammaglobulinemia in MS patients receiving anti-CD20 monoclonal antibodies, using data from the European spontaneous reporting system database, EudraVigilance. A total of 135 individual case safety reports (ICSRs), covering 469 adverse drug reactions (ADRs), were retrieved. The majority of ICSRs were related to ocrelizumab (N = 93) and involved cases of hypogammaglobulinemia occurring in adult females. Almost 20% of ICSRs reported concomitant medications, mainly represented by antibiotics, vitamins and antiepileptics. Among the 469 ADRs, 36.8% were serious, and 66% had an unknown outcome. The most commonly reported ADRs belonged to the SOC ‘Infections and infestations’ and included cases of COVID-19 and respiratory tract infection. Lastly, disproportionality analysis did not show a statistically significant probability of gamma globulin reduction comparing each drug. The study highlights the importance of monitoring for the occurrence of hypogammaglobulinemia and infections in patients receiving ocrelizumab, ofatumumab and rituximab for MS. These ADRs can be extremely serious and highlight the need for ongoing research to optimize their safety profiles.
Molecular genotyping and epidemiology of measles virus transmission in the World Health Organization European Region, 2007-2009
Creators: name: Mankertz, Annette
name: Mulders, Mick N.
name: Shulga, Sergey
name: Kremer, Jacques R.
name: Brown, Kevin E.
name: Santibanez, Sabine
name: Muller, Claude P.
name: Tikhonova, Nina
name: Lipskaya, Galina
name: Jankovic, Dragan
name: Khetsuriani, Nino
name: Martin, Rebecca
name: Gavrilin, Eugene
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2011
Subjects: subject: Humans
subject: Phylogeny
subject: Genotype
subject: Population Surveillance
subject: Europe/epidemiology
subject: Measles/epidemiology
subject: Measles virus/genetics
subject: Molecular Epidemiology
subject: Measles/transmission
subject: Measles/virology
subject: Measles virus/classification
subject: World Health Organization/organization & administration
subject: 610 Medizin

description: Background: In 2002, the World Health Organization (WHO) adopted a goal to eliminate measles in the European Region by 2010. Measles elimination is defined as the interruption of indigenous measles virus (MV) transmission. The molecular epidemiology of MV transmission in the WHO European Region was studied through the investigation of reported cases and outbreaks to monitor the region's progress toward its measles elimination goal. Methods: National and regional laboratories performed molecular characterization of MV detected between 2007 and 2009 in the WHO European Region. To document indigenous transmission and importations into the region, we analyzed genotyping results and epidemiological data on measles outbreaks reported by the member states. Results: Since 2007, MV genotype D6 has not been reported in the WHO European Region, suggesting that its chains of transmission have been interrupted, whereas several other MV genotypes are still circulating. Although several European countries have already interrupted indigenous MV transmission, genotyping showed that 3 endemic MV transmission chains have been reestablished in other countries. Conclusions: The WHO European Region 2010 goal will not be met, as indigenous transmission of MV has not been interrupted. As the region begins to document its process of elimination verification to monitor progress toward the goal, countries will need to ensure that genotyping is performed in all measles outbreaks.
Investigation on the particle size and shape of iron ore pellet feed using ball mill and HPGR grinding methods
Creators: name: Abazarpoor, Armin
name: Halali, Mohammad
Publisher: name: Faculty of Geoengineering, Mining and Geology, Wrocław University of Technology, Wrocław
Year: 2017
Subjects: HPGR
ball mill
particle size
particle shape
image analysis
SEM

description: Physicochemical Problems of Mineral Processing; ISSN 2084-4735
Neurotoxicity associated with chimeric antigen receptor T-cell therapy: a real-world study leveraging the FDA Adverse Event Reporting System
Creators: name: Zhai, Yinghong
name: Yuan, Lei
name: Fang, Shihua
name: Liu, Shenglian
name: Ye, Xiaofei
name: Shi, Wentao
name: Cao, Yang
name: He, Jia
name: Hu, Fangyuan
name: Xu, Feng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: CAR-T-associated neurotoxicity is extremely frequent with highly variable clinical presentation. Disproportionality analysis was conducted leveraging the FDA Adverse Event Reporting System (FAERS), covering the period from 1 January 2017, through 31 March 2023. The reporting odds ratio (ROR) and the information component (IC) were utilized to assess the adverse signals in total/individual CAR-T product. The lower limit of the ROR and IC 95% confidence interval (ROR025 and IC025) both exceeding threshold value (1 and 0, respectively) was considered a significant signal. Of the 60, 730 records associated with CAR-T, 11, 037 (18.17%) pertained to neurological events. Tisagenlecleucel exhibited the highest percentage of death (38.02%) and life‐threatening (12.90%) outcomes. Notably, it also displayed the broadest distribution of neurotoxicity. Additionally, distinct adverse signals unique to individual CAR-T products were identified. For instance, paraparesis, cerebral hemorrhage, impaired pupillary reflex, Guillain-Barre syndrome, brain death following tisagenlecleucel; dysarthria, orthostatic hypotension, and spinal cord edema after axicabtagene; parkinsonism, Bell’s palsy, and cranial nerve paralysis post ciltacabtagene. Axicabtagene ciloleucel, tisagenlecleucel, brexucabtagene autoleucel, lisocabtagene maraleucel, idecabtagene vicleucel, and ciltacabtagene autoleucel exhibited increased odds of neurotoxicity, with some discrepancies in their characteristics, profiles, and severity.
The Impact of Medication Regimen Complexity Score on Multi-Organ Dysfunction and Clinical Outcomes in Critically Ill Patients: A Cohort Study
Creators: name: Al Aamer, Kholoud
name: Al Sulaiman, Khalid
name: Aljuhani, Ohoud
name: Alshehri, Sarah
name: Alshehri, Abdulmajeed M.
name: Aldawood, Lina
name: AlQurashi, Asmahan
name: Aloufi, Khuld
name: Kassem, Lamyaa
name: Nazel, Shahad
name: Albarqi, Khalid
name: Alsaeedi, Alawi S
name: Alonazi, Shaden
name: Alqahtani, Afnan
name: Alhmoud, Munirah
name: Aljohani, Majidah
name: Bahri, Qasem A.
name: Alanazi, Abdulaziz
name: Jassar, Saud
name: Alnasser, Bader
name: Alqadi, Razan
name: Alqumia, Amal
name: Al-Dorzi, Hasan M
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Evidence is limited on the utilization of the Medication Regimen Complexity – Intensive Care Unit (MRC-ICU) scores for predicting clinical outcomes in critically ill patients. Therefore, this study aims to examine the impact of the MRC-ICU score on clinical outcomes for critically ill patients. A single-center retrospective cohort study included adult ICU patients admitted for >72 hours between January and December 2021. Patients were categorized into two groups based on MRC-ICU scores assessed within 24 hours of ICU admission. The primary endpoint was the Multiorgan Dysfunction (MOD) score at 72 hours of ICU admission. Other clinical outcomes were considered secondary. Of the 1406 patients included, 718 had an MRC-ICU score of nine or higher. Patients with MRC-ICU scores ≥9 had significantly higher MOD scores at 72 hours (median 5 vs 3, p < 0.001), longer hospital LOS, and higher mortality rates in crude analyses. Regression analysis showed a significant association between MRC-ICU score and MOD score at day 3 of ICU admission (coefficient: 0.49, 95% CI 0.07 to 0.92, p = 0.02). However, no significant differences were observed with ICU-LOS, vasopressor-free days, or mortality. Higher MRC-ICU scores might be linked to worse clinical outcomes, including greater organ dysfunction, and longer hospital stay.
EVALUATION OF PYRIPROXYFEN APPLIED IN BARRIER SPRAYS FOR MOSQUITO SUPPRESSION
Creators: name: Skiles, Andrea Glenn
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Entomology
subject: Environmental Public Health
subject: Veterinary Infectious Diseases
subject: Veterinary Preventive Medicine, Epidemiology, and Public Health

description: Despite advances in mosquito management, mosquito-borne disease in the United States is still of relevant public health concern and vector control is a top priority in preventing transmission of pathogens. Insecticide barrier sprays have become a common tool for suppression of mosquitoes in single-homeowner backyards. The application of the synthetic pyrethroid, lambda-cyhalothrin to perimeter vegetation with a backpack sprayer has been shown to significantly suppress mosquito levels for around 6 weeks. In an attempt to lengthen the effective duration of treatment, the IGR, pyriproxyfen, was added to a backpack mist blower with lambda-cyhalothrin, as adult mosquitoes exposed to pyriproxyfen have been shown to disseminate it to oviposition sites and to experience lowered fecundity. This treatment was compared to lambda-cyhalothrin alone and to a water control. Mosquito populations were sampled using CO2-baited CDC light traps, CDC gravid traps, human landing rates, and ovitraps. Leaf bioassays were performed. The following summer, the same treatments were applied with a truck-mounted mist blower to tree lines in Central Kentucky, to test the efficacy of an application method that could be used on large properties. Finally, bioassays were performed with water sampled from pyriproxyfen-treated containers, exposed to field conditions to test for residual efficacy.
Review of Rethinking Theatrical Documents in Shakespeare’s England edited by T. Stern (Bloomsbury 2020) and Loss and the Literary Culture of Shakespeare’s Time edited by R. Knutson, D. McInnis, and M. Steggle  (Palgrave 2020)
Creators: name: Tavares, Elizabeth
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: European drama--Renaissance
subject: Shakespeare, William, 1564-1616
subject: English drama
subject: Sixteenth century
subject: Seventeenth century
subject: Theater
subject: History

description: Elizabeth Tavares's double of review of Rethinking Theatrical Documents in Shakespeare’s England, edited by Tiffany Stern and Loss and the Literary Culture of Shakespeare’s Time, edited by Roslyn L. Knutson, David McInnis, and Matthew Steggle.
sj-pdf-1-sci-10.1177_00368504211029775 – Supplemental material for Euthanasia in adults with psychiatric conditions: A descriptive study of the experiences of Belgian psychiatrists
Creators: name: Verhofstadt, Monica
name: Audenaert, Kurt
name: Van den Broeck, Kris
name: Deliens, Luc
name: Mortier, Freddy
name: Titeca, Koen
name: De Bacquer, Dirk
name: Chambaere, Kenneth
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-pdf-1-sci-10.1177_00368504211029775 for Euthanasia in adults with psychiatric conditions: A descriptive study of the experiences of Belgian psychiatrists by Monica Verhofstadt, Kurt Audenaert, Kris Van den Broeck, Luc Deliens, Freddy Mortier, Koen Titeca, Dirk De Bacquer and Kenneth Chambaere in Science Progress