cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dirac equation in some homogeneous$sqace-times, separation of variables and exact solutions
Creators: name: Villalba, Víctor M.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In the present article, using a further generalization of the algebraic method of separation of variables, the Dirac equation is separated in a family of space-times where it is not possible to find a complete set of first order commuting differential operators. After separating variables, the Dirac equation is reduced to a set of coupled ordinary differential equations and some exact solutions corresponding to cosmological backgrounds and gravitational waves are computed in terms of hypergeometric functions. By passing, the Klein Gordon equation in this background field is discussed.
description: 19p, Latex, IVIC-CFLE-93/1
Synthesis, characterization, X-ray, α-glucosidase inhibition and molecular docking study of new triazolic systems based on 1,5-benzodiazepine via 1,3-dipolar cycloaddition reactions
Creators: name: Lahcen, Marouane Ait
name: Adardour, Mohamed
name: Mortada, Salma
name: Oubahmane, Mehdi
name: Hmaimou, Samir
name: Loughzail, Mohamed
name: Hdoufane, Ismail
name: Lahmidi, Sanae
name: Faouzi, My El Abbes
name: Cherqaoui, Driss
name: Mague, Joel T.
name: Baouid, Abdesselam
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: We report in this work a synthesis of novel triazolo[1,5]benzodiazepine derivatives by the 1,3-dipolar cycloaddition reaction of N-aryl-C-ethoxycarbonylnitrilimines with 1,5-benzodiazepines. All the structures of the new compounds were determined from their NMR (1H and 13C) and HRMS. Then, X-ray crystallography analysis of compound 4d confirmed the stereochemistry of cycloadducts. The compounds 1, 4a–d, 5a–d, 6c, 7 and 8 were evaluated for their in vitro anti-diabetic activity against α-glucosidase. The compounds 1, 4d, 5a and 5b showed potential inhibitory activities compared to standard acarbose. Additionally, an in silico docking study was conducted to look into the active binding mode of the synthesized compounds within the target enzyme. Communicated by Ramaswamy H. Sarma
The Identification and Characterisation of Genetic Signals of Selection in High Altitude Populations
Creators: name: Cole, Amy
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Populations dwelling at high altitude (greater than 2500 meters above sea-level) are exposed to harsh environmental elements including, extreme cold, dietary acculturation, increased UV irradiance and hypobaric hypoxia. There is approximately 60% of the oxygen available to populations at high altitude compared to at sea-level. The ability to adapt to this reduction in oxygen availability is fundamental to the preservation of function, and of life. Identifying and characterising the genes involved in adaptation to hypoxia therefore offers an important and unique insight into hypoxia in general, and can in turn inform on a variety of human conditions and diseases of public health importance. We established a geographically diverse cohort of high altitude populations, from the Himalaya, the Andes and the East African plateau, through fieldwork, collaborations and publically available datasets. Using both dense genotype data and whole genome sequencing we describe the population structure of these populations and apply a number of selection scans to identify regions of the genome that have undergone selection, enabling these populations to adapt to high altitude. We show that genes mirror geography in the Himalayan region. We identified the Sherpa as a remarkably genetically isolated population relative to their neighbouring Nepali populations, characterised by varying proportions of Tibetan and ‘ancestral north Indian’ ancestry. The Andean Quechua were a relatively homogenous population, despite the complex demographic history of South America. We identified genetic signatures of selection that were both unique and common to geographically diverse high altitude populations, suggesting that these populations may be at different stages of convergent evolution. We identified a novel candidate hypoxic pathway containing the genes; ErBb4, GAB1 and ARHGEF7. To verify the robust application of our statistical tests of selection, and highlight the translational potential of this research we performed a preliminarily characterisation of these three candidate hypoxic genes. We measured the effects of each gene knockdown on HIF-1α (hypoxic inducible factor - 1α), a protein involved in the body’s most vital oxygen homeostasis pathway, in an in-vitro hypoxic environment.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 389
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 389, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 389, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 8: of Echocardiographic parameters and renal outcomes in patients with preserved renal function, and mild- moderate CKD
Creators: name: Mavrakanas, Thomas
name: Khattak, Aisha
name: Karandeep Singh
name: Charytan, David
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: Computational Biology

description: Table S8. Adjusted associations of echocardiographic parameters with composite renal outcomes and mortality in patients without known CHF at baseline (DOCX 16 kb)
Constraint on ion-neutral drift velocity in the Class 0 protostar B335 from ALMA observations
Creators: name: Yen, Hsi-Wei
name: Zhao, Bo
name: Koch, Patrick M.
name: Krasnopolsky, Ruben
name: Li, Zhi-Yun
name: Ohashi, Nagayoshi
name: Takakuwa, Shigehisa
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Ambipolar diffusion can cause a velocity drift between ions and neutrals. This is one of the non-ideal MHD effects proposed to enable the formation of Keplerian disks with sizes of tens of au. To observationally study ambipolar diffusion in collapsing protostellar envelopes, we compare gas kinematics traced by the H13CO+ (3-2) and C18O (2-1) lines in the Class 0 protostar B335 obtained with our ALMA observations. A central compact (~1"-2") component that is elongated perpendicular to the outflow direction and exhibits a clear velocity gradient along the outflow direction is observed in both lines and most likely traces the infalling flattened envelope. We constructed kinematical models to fit the observed velocity structures and to measure the infalling velocities of the ionized and neutral gas on a 100 au scale in B335. The infalling velocities in the H13CO+ and C18O emission are both measured to be 0.85+/-0.2 km/s at a radius of 100 au, suggesting that the velocity drift between the ionized and neutral gas is at most 0.3 km/s at a radius of 100 au. The Hall parameter for H13CO+ is estimated to be >>1 on a 100 au scale in B335, so that H13CO+ is expected to be attached to the magnetic field. Our non-detection or upper limit of the velocity drift between ions and neutrals could suggest that the magnetic field remains rather well coupled to the bulk neutral material on a 100 au scale in this source, and that any significant field-matter decoupling, if present, likely occurs only on a smaller scale, leading to an accumulation of magnetic flux and thus efficient magnetic braking in the inner envelope. However, because of our limited angular resolution, we cannot rule out a significant ambipolar drift only in the midplane of the infalling envelope. Future observations with higher angular resolutions (~0.1") are needed to examine this possibility and ambipolar diffusion on a smaller scale.
description: Accepted by A&A
Additional file 1: of Do adolescents understand the items of the European Health Literacy Survey Questionnaire (HLS-EU-Q47) – German version? Findings from cognitive interviews of the project “Measurement of Health Literacy Among Adolescents” (MOHLAA) in Germany
Creators: name: Domanska, Olga
name: Firnges, Christiane
name: Bollweg, Torsten
name: Sørensen, Kristine
name: Holmberg, Christine
name: Jordan, Susanne
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: Table S1. German version of the European Health Literacy Survey Questionnaire tested in the MOHLAA study in Germany (12/2015–03/2016). (DOCX 53 kb)
Observable Majoron Emission in Neutrinoless Double Beta Decay
Creators: name: Berezhiani, Z
name: Smirnov, A Yu
name: Valle, J W F
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider a class of simplest Majoron models where neutrino- majoron couplings can be in the range $g \sim 10^{-5}-10^{-3}$ leading to the observability of neutrinoless double beta decay with majoron emission. The majoron is a singlet of the electroweak gauge symmetry, thus avoiding conflict with the LEP data on Z decay, which rules out the triplet and doublet majoron models.
description: (latex file, macro matex) 11pp (2 Figures that can be requested)
Radiative association and inverse predissociation of oxygen atoms
Creators: name: Babb, J. F.
name: Dalgarno, A.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The formation of $\mbox{O}_2$ by radiative association and by inverse predissociation of ground state oxygen atoms is studied using quantum-mechanical methods. Cross sections, emission spectra, and rate coefficients are presented and compared with prior experimental and theoretical results. At temperatures below 1000~K radiative association occurs by approach along the $1\,{}^3Π_u$ state of $\mbox{O}_2$ and above 1000~K inverse predissociation through the $\mbox{B}\,{}^3Σ_u^-$ state is the dominant mechanism. This conclusion is supported by a quantitative comparison between the calculations and data obtained from hot oxygen plasma spectroscopy.
description: submitted to Phys. Rev. A (Sept. 7., 1994), 19 pages, 4 figures, latex (revtex3.0 and epsf.sty)
Structural and functional characterization of 6-phosphogluconate dehydrogenase in Plasmodium falciparum (3D7) and identification of its potent inhibitors
Creators: name: Karthika, Alagesan
name: Hemavathy, Nagarajan
name: Amala, Mathimaran
name: Rajamanikandan, Sundaraj
name: Veerapandian, Malaisamy
name: Prabhu, Dhamodharan
name: Vetrivel, Umashankar
name: Chen, Chun Jung
name: Pandian, Chitra Jeyaraj
name: Jeyakanthan, Jeyaraman
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Computational Biology

description: The malarial parasite Plasmodium falciparum predominantly causes severe malaria and deaths worldwide. Moreover, resistance developed by P. falciparum to frontline drugs in recent years has markedly increased malaria-related deaths in South Asian Countries. Ribulose 5-phosphate and NADPH synthesized by Pentose Phosphate Pathway (PPP) act as a direct precursor for nucleotide synthesis and P. falciparum survival during oxidative challenges in the intra-erythrocytic growth phase . In the present study, we have elucidated the structure and functional characteristics of 6-phosphogluconate dehydrogenase (6PGD) in P. falciparum and have identified potent hits against 6PGD by pharmacophore-based virtual screening with ZINC and ChemBridge databases. Molecular docking and Molecular dynamics simulation, binding free energies (MMGBSA & MMPBSA), and Density Functional Theory (DFT) calculations were integratively employed to validate and prioritize the most potential hits. The 6PGD structure was found to have an open and closed conformation during MD simulation. The apo form of 6PGD was found to be in closed conformation, while a open conformation attributed to facilitating binding of cofactor. It was also inferred from the conformational analysis that the small domain of 6PGD has a high influence in altering the conformation that may aid in open/closed conformation of 6PGD. The top three hits identified using pharmacophore hypotheses were ChemBridge_11084819, ChemBridge_80178394, and ChemBridge_17912340. Though all three hits scored a high glide score, MMGBSA, and favorable ADMET properties, ChemBridge_11084819 and ChemBrdige_17912340 showed higher stability and binding free energy. Moreover, these hits also featured stable H-bond interactions with the active loop of 6PGD with binding free energy comparable to substrate-bound complex. Therefore, the ChemBridge_11084819 and ChemBridge_17912340 moieties demonstrate to have high therapeutic potential against 6PGD in P. falciparum. Communicated by Ramaswamy H. Sarma
The Pleiades apex and its kinematical structure
Creators: name: Elsanhoury, W. H.
name: Postnikova, E. S.
name: Chupina, N. V.
name: Vereshchagin, S. V.
name: Sariya, Devesh P.
name: Yadav, R. K. S.
name: Jiang, Ing-Guey
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A study of cluster characteristics and internal kinematical structure of the middle-aged Pleiades open star cluster is presented. The individual star apexes and various cluster kinematical parameters including the velocity ellipsoid parameters are determined using both Hipparcos and Gaia data. Modern astrometric parameters were taken from the Gaia Data Release 1 (DR1) in combination with the Radial Velocity Experiment Fifth Data Release (DR5). The necessary set of parameters including parallaxes, proper motions and radial velocities are used for n=17 stars from Gaia DR1+RAVE DR5 and for n=19 stars from the Hipparcos catalog using SIMBAD data base. Single stars are used to improve accuracy by eliminating orbital movements. RAVE DR5 measurements were taken only for the stars with the radial velocity errors not exceeding $2$~km/s. For the Pleiades stars taken from Gaia, we found mean heliocentric distance as $136.8 \pm 6.4$~pc, and the apex position is calculated as: $A_{CP}=92^\circ.52\pm1^\circ.72$, $D_{CP}=-42^\circ.28\pm2^\circ.56$ by the convergent point method and $A_0=95^\circ.59\pm2^\circ.30$ and $D_0=-50^\circ.90\pm2^\circ.04$ using AD-diagram method (n=17 in both cases). The results are compared with those obtained historically before the Gaia mission era.
description: 2 Figures, 4 Tables, Accepted for publication in Astrophysics and Space Science
The effects of kinetic instabilities on the electron cyclotron emission from runaway electrons
Creators: name: Liu, Chang
name: Shi, Lei
name: Hirvijoki, Eero
name: Brennan, Dylan P.
name: Bhattacharjee, Amitava
name: Paz-Soldan, Carlos
name: Austin, Max E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: In this paper we show that the kinetic instabilities associated with runaway electron beams play an essential role for the production of high-level non-thermal electron-cyclotron-emission (ECE) radiation. Most of the non-thermal ECE comes from runaway electrons in the low-energy regime with large pitch angle, which are strongly scattered by the excited whistler waves. The power of ECE from runaway electrons is obtained using a synthetic diagnostic model based on the reciprocity method. The electron distribution function is calculated using a kinetic simulation model including the whistler wave instabilities and the quasilinear diffusion effects. Simulations based on DIII-D low-density discharge reproduces the rapid growth of the ECE signals observed in DIII-D experiments. Unlike the thermal ECE where radiation for a certain frequency is strongly localized inside the resonance region, the non-thermal ECE radiation from runaway electrons is nonlocal, and the emission-absorption ratio is higher than that of thermal electrons. The runaway electron tail is more significant for ECE with higher frequencies, and the ECE spectrum becomes flatter as RE population grows. The nonlinear behavior of the kinetic instabilities is illustrated in the osculations of the ECE waves. The good agreement with the DIII-D experimental observations after including the kinetic instabilities clearly illustrate the significance of the scattering effects from wave-particle interactions, which can also be important for runaway electrons produced in disruptions.
Regulations for Dominion Forest Reserves
Creators: name: Canada--Department Of The Interior
name: Canada--Forest Research Branch
Publisher: name: The University of British Columbia
Year: 2017

description: Official government internal publication outlining the maintenance and management of all reserves set aside and established as Dominion Forest Reserves by the Dominion Forest Reserves and Parts Act, including outlins for the protection, care and utilization of the timber, minerals, animals, birds, fish and other natural resources of such reserves, and for the prevention of trespass therein.
A regularity theorem for solutions of the spherically symmetric Vlasov-Einstein system
Creators: name: Rein, Gerhard
name: Rendall, Alan D.
name: Schaeffer, Jack
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In a previous paper two of the authors (G. R. and A. D. R.) showed that there exist global, classical solutions of the spherically symmetric Vlasov-Einstein system for small initial data. The present paper continues this investigation and allows also large initial data. It is shown that if a solution of the spherically symmetric Vlasov-Einstein system develops a singularity at all then the first singularity has to appear at the center of symmetry. The result adds weight to the conjecture that cosmic censorship holds if one replaces dust as matter model for which naked singularities do form by a collisionless gas described by the Vlasov equation. The main tool is an estimate which shows that a solution is global if all the matter remains away from the center of symmetry.
description: 15 pages, Latex, report # 2
MOESM2 of Comparing 16S rDNA amplicon sequencing and hybridization capture for pea aphid microbiota diversity analysis
Creators: name: Cariou, Marie
name: Ribière, Céline
name: Morlière, Stéphanie
name: Gauthier, Jean-Pierre
name: Jean-Christophe Simon
name: Peyret, Pierre
name: Charlat, Sylvain
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 2. Details on sequence data processing.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 0190r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0190r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0190r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Multiple-Scattering Series For Color Transparency
Creators: name: Greenberg, W. R.
name: Miller, G. A.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Color transparency CT depends on the formation of a wavepacket of small spatial extent. It is useful to interpret experimental searches for CT with a multiple scattering scattering series based on wavepacket-nucleon scattering instead of the standard one using nucleon-nucleon scattering. We develop several new techniques which are valid for differing ranges of energy. These techniques are applied to verify some early approximations; study new forms of the wave-packet-nucleon interaction; examine effects of treating wave packets of non-zero size; and predict the production of $N^*$'s in electron scattering experiments.
description: 26 pages, U.Wa. preprint 40427-23-N92
Synthesis, characterization, X-ray, α-glucosidase inhibition and molecular docking study of new triazolic systems based on 1,5-benzodiazepine via 1,3-dipolar cycloaddition reactions
Creators: name: Lahcen, Marouane Ait
name: Adardour, Mohamed
name: Mortada, Salma
name: Oubahmane, Mehdi
name: Hmaimou, Samir
name: Loughzail, Mohamed
name: Hdoufane, Ismail
name: Lahmidi, Sanae
name: Faouzi, My El Abbes
name: Cherqaoui, Driss
name: Mague, Joel T.
name: Baouid, Abdesselam
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: We report in this work a synthesis of novel triazolo[1,5]benzodiazepine derivatives by the 1,3-dipolar cycloaddition reaction of N-aryl-C-ethoxycarbonylnitrilimines with 1,5-benzodiazepines. All the structures of the new compounds were determined from their NMR (1H and 13C) and HRMS. Then, X-ray crystallography analysis of compound 4d confirmed the stereochemistry of cycloadducts. The compounds 1, 4a–d, 5a–d, 6c, 7 and 8 were evaluated for their in vitro anti-diabetic activity against α-glucosidase. The compounds 1, 4d, 5a and 5b showed potential inhibitory activities compared to standard acarbose. Additionally, an in silico docking study was conducted to look into the active binding mode of the synthesized compounds within the target enzyme. Communicated by Ramaswamy H. Sarma
Global existence of classical solutions to the Vlasov-Poisson system in a three dimensional, cosmological setting
Creators: name: Rein, Gerhard
name: Rendall, Alan D.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The initial value problem for the Vlasov-Poisson system is by now well understood in the case of an isolated system where, by definition, the distribution function of the particles as well as the gravitational potential vanish at spatial infinity. Here we start with homogeneous solutions, which have a spatially constant, non-zero mass density and which describe the mass distribution in a Newtonian model of the universe. These homogeneous states can be constructed explicitly, and we consider deviations from such homogeneous states, which then satisfy a modified version of the Vlasov-Poisson system. We prove global existence and uniqueness of classical solutions to the corresponding initial value problem for initial data which represent spatially periodic deviations from homogeneous states.
description: 23 pages, Latex, report # 3
Platelet Function in Inflammatory Arthritis
Creators: name: MacMullan, Paul
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Patients with inflammatory arthritis (IA) are at increased risk of adverse cardiovascular events. While traditional risk factors are important, recent evidence highlights the key role of inflammation in cardiovascular disease (CVD). Platelets play a key patho-physiological role in the complex chain of events leading to the occlusion of a coronary artery. To date, platelet function in the IA population has been poorly investigated. We examined platelet function in patients with IA and assessed the influence of disease activity on platelet reactivity. Our data demonstrate an enhanced platelet response, unique to ADP stimulation, in patients with inflammatory arthritis whose disease is poorly controlled. Remarkably there was no difference in platelet reactivity noted in response to any of the other agonists tested (arachidonic acid, collagen, epinephrine, and TRAP). Using both ex vivo measures of platelet function and in vitro assays we then investigated the amplifying effect of several pro-inflammatory cytokines (IL-1b, IL-6, anti-TNFaand IL17a) on the platelet ADP pathway and also found a decreased platelet ADP response in patients with previously refractory disease who were treated with the IL-6 inhibitor tocilizumab. Following our observation of an, heretofore unknown, inhibitory effect of sulfasalazine therapy on platelet aggregation, we subsequently demonstrate that this is due to both the parent compound and its metabolites, and confined to the arachidonic acid pathway. Finally, we prospectively assessed the impact of improved disease control with anti-TNFaagents on platelet function, insulin metabolism, and cholesterol levels in patients with IA. We found patients who respond to anti-TNFatherapy also achievea normalization of platelet function and decreased insulin resistance, with no change in lipid profile. Taken together, these findings offer novel mechanistic insights into how inflammation and its treatment influences platelet function and CVD risk in this vulnerable patient population, for whom anti-platelet guidelines are currently lacking.
Molecular Dynamics Simulations of a Pressure-induced Glass Transition
Creators: name: Shumway, Shelly L.
name: Clarke, Andrew S.
name: Jónsson, Hannes
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We simulate the compression of a two-component Lennard-Jones liquid at a variety of constant temperatures using a molecular dynamics algorithm in an isobaric-isothermal ensemble. The viscosity of the liquid increases with pressure, undergoing a broadened transition into a structurally arrested, amorphous state. This transition, like the more familiar one induced by cooling, is correlated with a significant increase in icosahedral ordering. In fact, the structure of the final state, as measured by an analysis of the bonding, is essentially the same in the glassy, frozen state whether produced by squeezing or by cooling under pressure. We have computed an effective hard-sphere packing fraction at the transition, defining the transition pressure or temperature by a cutoff in the diffusion constant, analogous to the traditional laboratory definition of the glass transition by an arbitrary, low cutoff in viscosity. The packing fraction at this transition point is not constant, but is consistently higher for runs compressed at higher temperature. We show that this is because the transition point defined by a constant cutoff in the diffusion constant is not the same as the point of structural arrest, at which further changes in pressure induce no further structural changes, but that the two alternate descriptions may be reconciled by using a thermally activated cutoff for the diffusion constant. This enables estimation of the characteristic activation energy for diffusion at the point of structural arrest.
description: Latex using Revtex macros
Additional file 5: of Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir
Creators: name: Pavitra Roychoudhury
name: Harshana De Silva Feelixge
name: Reeves, Daniel
name: Mayer, Bryan
name: Stone, Daniel
name: Schiffer, Joshua
name: Jerome, Keith
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary methods: c reporter design. (DOCX 1641Â kb)
Optical Kerr spatiotemporal dark extreme waves
Creators: name: Wabnitz, Stefan
name: Kodama, Yuji
name: Baronio, Fabio
Publisher: name: arXiv
Year: 2018
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We study the existence and propagation of multidimensional dark non-diffractive and non-dispersive spatiotemporal optical wave-packets in nonlinear Kerr media. We report analytically and confirm numerically the properties of spatiotemporal dark lines, X solitary waves and lump solutions of the (2 + 1)D nonlinear Schrodinger equation (NLSE). Dark lines, X waves and lumps represent holes of light on a continuous wave background. These solitary waves are derived by exploiting the connection between the (2 + 1)D NLSE and a well-known equation of hydrodynamics, namely the (2+1)D Kadomtsev-Petviashvili (KP) equation. This finding opens a novel path for the excitation and control of spatiotemporal optical solitary and rogue waves, of hydrodynamic nature.
description: arXiv admin note: text overlap with arXiv:1608.08771, arXiv:1602.08464
Potential inhibitors of RPS6KB2 and NRF2 in head and neck squamous cell carcinoma
Creators: name: Madhukar, Geet
name: Subbarao, Naidu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Among the major altered pathways in head and neck squamous cell carcinoma, AKT/mTORC1/S6K and NRF2/KEAP1 pathway are quite significant. The overexpression and overstimulation of proteins from both these pathways makes them the promising candidates in cancer therapeutics. Inhibiting mTOR has been in research from past several decades but the tumour heterogeneity, and upregulation of several compensatory feed-back mechanisms, encourages to explore other downstream targets for inhibiting the pathway. One such downstream effectors of mTOR is S6K2. It is reported to be overexpressed in cancers such as head and neck cancer, breast cancer and prostate cancer. In case of NRF2/KEAP1 pathway, nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2) is overexpressed in ∼90% of head and neck squamous cell carcinoma (HNSCC) cases. It associates with poor survival rate and therapeutic resistance in HNSCC treatment. NRF2 pathway is the primary antioxidant pathway in the cell which also serves pro-tumorigenic functions, such as repression of apoptosis, cell proliferation support and chemoresistance. The aim of this work was to explore S6K2 and NRF2 and identify novel and potential inhibitors against them for treating head and neck squamous cell carcinoma. Since the crystal structure of S6K2 was not available at the time of this study, we modelled its structure using homology modelling and performed high throughput screening, molecular dynamics simulations, free energy calculations and protein-ligand interaction studies to identify the inhibitors. We identified natural compounds Crocin and Gypenoside XVII against S6K2 and Chebulinic acid and Sennoside A against NRF2. This study provides a significant in-depth understanding of the two studied pathways and therefore can be used in the development of potential therapeutics against HNSCC. Communicated by Ramaswamy H. Sarma
Realistic Hadronic Matrix Element Approach to Color Transparency
Creators: name: Jennings, B. K.
name: Miller, G. A.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Color transparency occurs if a small-sized wave packet, formed in a high momentum transfer process, escapes the nucleus before expanding. The time required for the expansion depends on the masses of the baryonic components of the wave packet. Measured proton diffractive dissociation and electron deep inelastic scattering cross sections are used to examine and severely constrain the relevant masses. These constraints allow significant color transparency effects to occur at experimentally accessible momentum transfers.
description: 12 pages, U.Wa. 40427-24-N92,TRIUMF TR-pp-92-48
A Higgs--Chern-Simons gravity model in 2+1 dimensions
Creators: name: Radu, Eugen
name: Tchrakian, D. H.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study a gravity model in 2+1 dimensions, arising from a generalized Chern-Simons (CS) density we call a Higgs-Chern-Simons (HCS) density. This generalizes the construction of gravitational systems resulting from non-Abelian CS densities in all odd dimensions. The new HCS densities employed here are arrived at by the usual one-step descent of new Higgs--Chern-Pontryagin (HCP) densities, the latter resulting from the dimensional reduction of Chern-Pontryagin (CP) densities in some even dimension, such that in any given dimension (including even) there is an infinite tower of such models. Here, we restrict our attention to the lowest dimension, 2+1, and to the simplest such model resulting from the dimensional reduction of the $3$-rd CP density. We construct a black hole (BH) solution in closed form, generalizing the familiar BTZ BH. We also study the electrically charged BH solution of the same model augmented with a Maxwell term, and contrast this solution with the electrically charged BTZ BH, specifically concering their respective thermodynamic properties.
description: 12 pages, 3 figures
Improving the Recognition and Management of Common Mental Disorders in Government-Operated Primary Care Settings in Penang, Malaysia: Feasibility of a Pilot Primary Care Consultation-Liaison Psychiatry Service and Impact on Undergraduate Medical Education
Creators: name: Russell, Vincent
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: International evidence suggests that the implementation of evidence-based interventions for common mental disorders (CMDs) in primary care settings is challenging, especially in low and middle-income countries. This thesis is based on a clinical and medical educational research initiative carried out by the author at Penang Medical College, Malaysia in collaboration with local academic colleagues and clinicians and support from academics in his home institution in RCSI, Dublin. The aims of the study were to explore challenges and opportunities in delivering enhanced care for CMDs in Malaysian government-operated primary care clinics and the potential added educational value of medical students learning psychiatry in primary care settings. Mixed qualitative and quantitative methods and a process evaluation framework were employed to evaluate current primary care services for CMDs and the operation and utilisation of an on-site pilot consultation-liaison psychiatry service at two primary care clinics in Penang. Semi-structured individual interviews with front-line clinicians and focus groups with medical students explored perceptions of CMDs and the experience of participation in the pilot intervention. The study found that barriers to the recognition and management of CMDs arose from weak structures and processes to support current primary care mental health policy implementation. Other challenges include competing service demands on frontline clinicians and limitations in clinicians’ understanding of the benefits of recognition and management of CMDs. The pilot consultation-liaison intervention, however, was broadly implemented and utilised as intended and participating front-line clinicians appeared to value holistic care and reported a change in their understanding of CMDs. Medical students rated their primary care experiences as providing considerable added value in comparison with other clinical placements in questionnaire survey responses and in focus group thematic findings. These results highlight the need for and potential benefits from investment in front-line clinician support from family medicine and mental health specialists in the future implementation of evidence-based programmes for CMDs in Malaysian primary care settings. In addition, the study suggests that primary care experiences should be considered as a regular component of the clinical clerkship in psychiatry for medical undergraduates.
Reversible Work Transiton State Theory: Application to Dissociative Adsorption of Hydrogen
Creators: name: Mills, Gregory
name: Jonsson, Hannes
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A practical method for finding free energy barriers for transitions in high-dimensional classical and quantum systems is presented and used to calculate the dissociative sticking probability of H2 on a metal surface within transition state theory (TST). The reversible work involved in shifting the system confined to a hyperplane from the reactant region towards products is evaluated directly. Quantum mechanical degrees of freedom are included by using Feynman Path Integrals with the hyperplane constraint applied to the centroid of the cyclic paths. An optimal dividing surface for the rate estimated by TST is identified naturally in the course of the reversible work evaluation. The free energy barrier is determined relative to the reactant state directly, so an estimate of the transition rate can be obtained without requiring a solvable reference model for the transition state. The method has been applied to calculations of the sticking probability of a thermalized hydrogen gas on a Cu(110) surface. The two hydrogen atoms were included quantum mechanically, and over two hundred atoms in the Cu crystal where included classically. The activation energy for adsorption and desorption was determined and found to be significantly lowered by tunneling at low temperature. The calculated values agree quite well with experimental estimates. Dynamical corrections to the classical TST rate estimate were evaluated and found to be small.
description: Surface Science (in press), 42 pages without figures, tex, 16 postscript figures available via WWW at http://www-theory.chem.washington.edu/~mills/h2cufigures.html
Bioassay-guided identification of antithrombotic compounds from Cnidoscolus aconitifolius (Mill.) I. M. Jhonst.: molecular docking, bioavailability, and toxicity prediction
Creators: name: Martínez, Juan Pablo Quintal
name: Ortiz, Irma Guadalupe Quintal
name: Salomón, Ligia Gabriela Alonso
name: García-Sosa, Karlina
name: Rodríguez, Luis Manuel Peña
name: Analco, José Antonio Guerrero
name: Villanueva, Juan Luis Monribot
name: Limón, Abraham Marcelino Vidal
name: Campos, Maira Rubi Segura
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Conventional antithrombotic therapy has reported hemorrhagic accidents. Ethnobotanical and scientific reports point to Cnidoscolus aconitifolius as an antithrombotic adjuvant. Previously, C. aconitifolius leaves ethanolic extract displayed antiplatelet, anticoagulant, and fibrinolytic activities. This work aimed to identify compounds from C. aconitifolius with in vitro antithrombotic activity through a bioassay-guided study. Antiplatelet, anticoagulant, and fibrinolytic tests guided the fractionation. Ethanolic extract was subjected to a liquid–liquid partitioning, followed by vacuum liquid, and size exclusion chromatography to obtain the bioactive JP10B fraction. The compounds were identified through UHPLC-QTOF-MS, and their molecular docking, bioavailability, and toxicological parameters were determined computationally. Kaempferol-3-O-glucorhamnoside and 15(S)-HPETE were identified; both showed affinity for antithrombotic targets, low absorption, and safety for human consumption. Further in vitro and in vivo evaluations will better understand their antithrombotic mechanism. This bioassay-guided fractionation demonstrated that C. aconitifolius ethanolic extract has antithrombotic compounds. Communicated by Ramaswamy H. Sarma
Additional file 1: of Do adolescents understand the items of the European Health Literacy Survey Questionnaire (HLS-EU-Q47) – German version? Findings from cognitive interviews of the project “Measurement of Health Literacy Among Adolescents” (MOHLAA) in Germany
Creators: name: Domanska, Olga
name: Firnges, Christiane
name: Bollweg, Torsten
name: Sørensen, Kristine
name: Holmberg, Christine
name: Jordan, Susanne
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: Table S1. German version of the European Health Literacy Survey Questionnaire tested in the MOHLAA study in Germany (12/2015–03/2016). (DOCX 54 kb)
Molecular interactions and binding dynamics of Alpelisib with serum albumins: insights from multi-spectroscopic techniques and molecular docking
Creators: name: Jalan, Ankita
name: Moyon, N. Shaemningwar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Alpelisib (ALP) is a potent anti-cancer drug showing promising activity against advanced breast cancers. Hence, profound understanding of its binding dynamics within the physiological system is vital. Herein, we have investigated interaction of ALP with human serum albumin (HSA) and bovine serum albumin (BSA) using spectroscopic techniques like absorption, fluorescence, time-resolved, synchronous and 3D-fluorescence, FRET, FT-IR, CD, and molecular docking studies. The intrinsic fluorescence of both BSA and HSA quenched significantly by ALP with an appreciable red shift in its emission maxima. Stern-Volmer analysis showed increase in Ksv with temperature indicating involvement of dynamic quenching process. This was further validated by no significant change in absorption spectrum of BSA and HSA (at 280 nm) upon ALP interaction, and by results of fluorescence time-resolved lifetime studies. ALP exhibited moderately strong binding affinity with BSA (of the order 106 M−1) and HSA (of the order 105 M−1), and the major forces accountable for stabilizing the interactions are hydrophobic forces. Competitive drug binding experiments and molecular docking suggested that ALP binds to site I in subdomain IIA of BSA and HSA. The Förster distance r was found to be less than 8 nm and 0.5 Ro < r < 1.5 Ro which suggests possible energy transfer between donors BSA/HSA and acceptor ALP. Synchronous and 3D-fluoresecnce, FT-IR and CD studies indicated that ALP induces conformational changes of BSA and HSA upon interaction. Communicated by Ramaswamy H. Sarma
The No-Hair Conjecture in 2D Dilaton Supergravity
Creators: name: Gamboa, J.
name: Georgelin, Y.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study two dimensional dilaton gravity and supergravity following hamiltonian methods. Firstly, we consider the structure of constraints of 2D dilaton gravity and then the 2D dilaton supergravity is obtained taking the squere root of the bosonic constraints. We integrate exactly the equations of motion in both cases and we show that the solutions of the equation of motion of 2D dilaton supergravity differs from the solutions of 2D dilaton gravity only by boundary conditions on the fermionic variables, i.e. the black holes of 2D dilaton supergravity theory are exactly the same black holes of 2D bosonic dilaton gravity modulo supersymmetry transformations. This result is the bidimensional analogue of the no-hair theorem for supergravity.
description: Plain Tex, 19pp, IPNO-TH 93/25