cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter
Creators: name: Cyr, Douglas M.
name: Shuto, Tsuyoshi
name: Kaneko, Masayuki
name: Suico, Mary Ann
name: Kai, Hirofumi
name: Suzuki, Hiroshi
name: Sato, Takashi
name: Suzuki, Shingo
name: Takada, Tappei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: N-glycosylation of proteins in endoplasmic reticulum is critical for protein quality control. We showed here a post-translational N-glycosylation affected by the HRD1 E3 ubiquitin ligase. Both WT- and E3-defective C329S-HRD1 decreased the level of high mannose form of ABCG8, a protein that heterodimerizes with ABCG5 to control sterol balance. Meanwhile, HRD1 increased the non-glycosylated ABCG8 regardless of its E3 activity, thereby suppressing full maturation of ABCG5/8 transporter. Pulse chase and mutational analysis indicated that HRD1 inhibits STT3B-dependent post-translational N-glycosylation of ABCG8. Whereas, HRD1 had only slight effect on the N-glycosylation status of ABCG5; rather it accelerated ABCG5 degradation in an E3 activity-dependent manner. Finally, RMA1, another E3 ubiquitin ligase, accelerated the degradation of both ABCG5 and ABCG8 via E3 activity-dependent manner. HRD1 and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5/ABCG8. The findings also highlight the unexpected E3 activity-independent role of HRD1 in the regulation of N-glycosylation.
ПРАВОВЫЕ ОСНОВЫ ОБЕСПЕЧЕНИЯ УЕЗДНОЙ ПОЛИЦЕЙСКОЙ СТРАЖИ РОССИЙСКОЙ ИМПЕРИИ КОННЫМ СОСТАВОМ (НА ПРИМЕРЕ ВОРОНЕЖСКОЙ ГУБЕРНИИ)
Creators: name: Ситников К.А.
Publisher: name: Образование и право
Year: 2022
Subjects: уездная полиция
полицейская стража
урядник
стражник
конный состав
материальное обеспечение
Воронежская губерния.

description: В статье анализируется нормативно-правовая база приобретения, поддержания в должном состоянии и обновления конного состава уездной полицейской стражи Российской империи. Автор уделяет особое внимание роли Комиссии под председательством командующего Отдельным корпусом жандармов В. А. Дедюлина 1906 года в упорядочивании указанного круга общественных отношений.
ПРАВОВЫЕ ОСНОВЫ ФОРМИРОВАНИЯ ДВУХПОЛЮСНОЙ ПАРТИЙНОЙ СИСТЕМЫ В ПОСЛЕВОЕННЫЙ ПЕРИОД В СТРАНАХ ЕВРОПЫ
Creators: name: Зайцев И.И.
Publisher: name: Образование и право
Year: 2022
Subjects: Европа
партия
партийная система
двухпартийная система
многопартийная система.

description: В данной статье автор рассматривает внешние и внутренние причины формирования в ряде европейских государств двухполюсной политической системы. Противостояние между левыми и правыми политическими силами отразилось на структуре партийных систем ряда европейских государств. Это привело к формированию двух идеологически противоборствующих полюсов, где остальные политические партии оказались маргинальны и не могли играть значимой роли в партийной системе. Важное значение этой статьи автор усматривает в связи с кризисом двухпартийной системы, наблюдаемой сегодня в странах Европы.
The Radiated Energy Budget of Chromospheric Plasma in a Major Solar Flare Deduced From Multi-Wavelength Observations
Creators: name: Milligan, Ryan O.
name: Kerr, Graham S.
name: Dennis, Brian R.
name: Hudson, Hugh S.
name: Fletcher, Lyndsay
name: Allred, Joel C.
name: Chamberlin, Phillip C.
name: Ireland, Jack
name: Mathioudakis, Mihalis
name: Keenan, Francis P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: This paper presents measurements of the energy radiated by the lower solar atmosphere, at optical, UV, and EUV wavelengths, during an X-class solar flare (SOL2011-02-15T01:56) in response to an injection of energy assumed to be in the form of nonthermal electrons. Hard X-ray observations from RHESSI were used to track the evolution of the parameters of the nonthermal electron distribution to reveal the total power contained in flare accelerated electrons. By integrating over the duration of the impulsive phase, the total energy contained in the nonthermal electrons was found to be $>2\times10^{31}$ erg. The response of the lower solar atmosphere was measured in the free-bound EUV continua of H I (Lyman), He I, and He II, plus the emission lines of He II at 304Å and H I (Ly$α$) at 1216Å by SDO/EVE, the UV continua at 1600Å and 1700Å by SDO/AIA, and the WL continuum at 4504Å, 5550Å, and 6684Å, along with the Ca II H line at 3968Å using Hinode/SOT. The summed energy detected by these instruments amounted to $\sim3\times10^{30}$ erg; about 15% of the total nonthermal energy. The Ly$α$ line was found to dominate the measured radiative losses. Parameters of both the driving electron distribution and the resulting chromospheric response are presented in detail to encourage the numerical modelling of flare heating for this event, to determine the depth of the solar atmosphere at which these line and continuum processes originate, and the mechanism(s) responsible for their generation.
description: 14 pages, 18 figures. Accepted for publication in Astrophysics Journal
Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms
Creators: name: Chen, Gang
name: Qin, F. Xiao-Feng
name: Wang, Shanshan
name: Liu, Ping
name: Yi, Zhaohong
name: Tian, Huabin
name: Su, Lishan
name: Cheng, Genhong
name: Chen, Xinwen
name: Zhong, Jin
name: Deng, Hongyu
name: Li, Yanhua
name: Chen, Yongzhi
name: Du, Peishuang
name: Aliyari, Roghiyh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol (25HC), which is believed to inhibit the virus-cell membrane fusion during viral entry. However, little is known about the function of CH25H on HCV infection and replication and whether antiviral function of CH25H is exclusively mediated by 25HC. In the present study, we have found that although 25HC produced by CH25H can inhibit HCV replication, CH25H mutants lacking the hydroxylase activity still carry the antiviral activity against HCV but not other viruses such as MHV-68. Further studies have revealed that CH25H can interact with the NS5A protein of HCV and inhibit its dimer formation, which is essential for HCV replication. Thus, our work has uncovered a novel mechanism by which CH25H restricts HCV replication, suggesting that CH25H inhibits viral infection through both 25HC-dependent and independent events.
Additional file 3 of The usefulness of the total metabolic tumor volume for predicting the postoperative recurrence of thoracic esophageal squamous cell carcinoma
Creators: name: Kaida, Hayato
name: Yasuda, Takushi
name: Shiraishi, Osamu
name: Kato, Hiroaki
name: Kimura, Yutaka
name: Hanaoka, Kohei
name: Yamada, Minoru
name: Matsukubo, Yuko
name: Tsurusaki, Masakatsu
name: Kitajima, Kazuhiro
name: Hattori, Satoshi
name: Ishii, Kazunari
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 3.
Maximizing oyster-reef growth supports green infrastructure with accelerating sea-level rise
Creators: name: Brodeur, Michelle C.
name: Rodriguez, Antonio B.
name: Theuerkauf, Ethan J.
name: Joel Fodrie, F.
name: Lindquist, Niels L.
name: Grabowski, Jonathan H.
name: Ridge, Justin T.
name: Coleman, Sara E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Within intertidal communities, aerial exposure (emergence during the tidal cycle) generates strong vertical zonation patterns with distinct growth boundaries regulated by physiological and external stressors. Forecasted accelerations in sea-level rise (SLR) will shift the position of these critical boundaries in ways we cannot yet fully predict, but landward migration will be impaired by coastal development, amplifying the importance of foundation species’ ability to maintain their position relative to rising sea levels via vertical growth. Here we show the effects of emergence on vertical oyster-reef growth by determining the conditions at which intertidal reefs thrive and the sharp boundaries where reefs fail, which shift with changes in sea level. We found that oyster reef growth is unimodal relative to emergence, with greatest growth rates occurring between 20–40% exposure, and zero-growth boundaries at 10% and 55% exposures. Notably, along the lower growth boundary (10%), increased rates of SLR would outpace reef accretion, thereby reducing the depth range of substrate suitable for reef maintenance and formation, and exacerbating habitat loss along developed shorelines. Our results identify where, within intertidal areas, constructed or natural oyster reefs will persist and function best as green infrastructure to enhance coastal resiliency under conditions of accelerating SLR.
ПРИКЛАДНЫЕ ЗАКОНОДАТЕЛЬНЫЕ ИНИЦИАТИВЫ РОССИЙСКИХ ОМБУДСМЕНОВ В РЕШЕНИИ ПРОБЛЕМ РОССИЙСКОГО БИЗНЕСА
Creators: name: Катунина М.В.
Publisher: name: Образование и право
Year: 2022
Subjects: Уполномоченный по защите прав предпринимателей
системные проблемы российского бизнеса
законодательные инициативы
Стратегия развития малого и среднего предпринимательства в Российской Федерации
малое и среднее предпринимательство
предпринимательское сообщество.

description: В статье впервые сделан аналитический обзор 37 направлений системных проблем российского бизнеса, которые обозначены межрегиональным экспертным сообществом при Уполномоченном при Президенте Российской Федерации по защите прав предпринимателей. Благодаря работе межрегиональных экспертных групп появилось более 300 законодательных инициатив по 37 тематическим направлениям. Предпринимательское сообщество надеется, что федеральный Уполномоченный по защите прав предпринимателей доведет каждую законодательную инициативу до рассмотрения в Государственной Думе Федерального Собрания Российской Федерации.
Minimally destructive sampling of type specimens of Pyropia (Bangiales, Rhodophyta) recovers complete plastid and mitochondrial genomes
Creators: name: Ruediger, Erik
name: Tortolani, Jacquie
name: Miller, Kathy Ann
name: Young, Joel D.
name: Hughey, Jeffery R.
name: Silva, Mayra
name: Gabrielson, Paul W.
name: Martell, Craig
name: Rohmer, Laurence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Plant species, including algae and fungi, are based on type specimens to which the name of a taxon is permanently attached. Applying a scientific name to any specimen therefore requires demonstrating correspondence between the type and that specimen. Traditionally, identifications are based on morpho-anatomical characters, but recently systematists are using DNA sequence data. These studies are flawed if the DNA is isolated from misidentified modern specimens. We propose a genome-based solution. Using 4 × 4 mm2 of material from type specimens, we assembled 14 plastid and 15 mitochondrial genomes attributed to the red algae Pyropia perforata, Py. fucicola, and Py. kanakaensis. The chloroplast genomes were fairly conserved, but the mitochondrial genomes differed significantly among populations in content and length. Complete genomes are attainable from 19th and early 20th century type specimens; this validates the effort and cost of their curation as well as supports the practice of the type method.
Dynamical holographic QCD model
Creators: name: Li, Danning
name: Huang, Mei
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We develop a dynamical holographic QCD model, which resembles the renormalization group from ultraviolet (UV) to infrared (IR). The dynamical holographic model is constructed in the graviton-dilaton-scalar framework with the dilaton background field $Φ$ and scalar field $X$ responsible for the gluodynamics and chiral dynamics, respectively. We summarize our results on hadron spectra, QCD phase transition and transport properties including the jet quenching parameter and the shear/bulk viscosity in the framework of the dynamical holographic QCD model.
description: 8 pages, 5 figures, proceedings for QCD@Work2014, June 16-19,2014, Bari, Italy
ПРОБЛЕМЫ ДЕЛЕНИЯ ВЕЩЕЙ НА ДВИЖИМЫЕ И НЕДВИЖИМЫЕ В СВЕТЕ ИЗМЕНЕНИЙ НОРМ ГК РФ О НЕДВИЖИМОСТИ, ВНЕСЕННЫХ ФЕДЕРАЛЬНЫМ ЗАКОНОМ № 430-ФЗ ОТ 21.12.2021
Creators: name: Кондратюк Д.Л.
name: Лахин Д.Н.
name: Меерович Н.А.
Publisher: name: Образование и право
Year: 2022
Subjects: деление вещей на движимые и недвижимые
признаки недвижимости
критерии разграничения движимых и недвижимых вещей
функциональная возможность вещи
сооружения
прочная связь с землей
несоразмерный ущерб назначению.

description: Cтатья посвящена проблемам деления вещей на движимые и недвижимые. В юридической литературе отмечена недостаточность указанных в законе критериев разграничения движимых и недвижимых вещей. Вследствие такой недостаточности неоднозначно формировалась судебная практика по спорам о признании права собственности на недвижимое имущество. В результате нарушался общеправовой принцип определенности правовых норм. Тем не менее, в судебной практике сложились дополнительные критерии разграничения движимых и недвижимых вещей, один из которых с 01 сентября 2022 года получил свое закрепление в Гражданском кодексе Российской Федерации. В статье обосновывается целесообразность закрепления в ГК РФ еще одного признака недвижимой вещи, ее самостоятельного назначения; условий для отнесения сооружения к недвижимым вещам; а также обосновывается целесообразность формализации категории «прочная связь с землей», «несоразмерный ущерб назначению» в подзаконных нормативно-правовых актах.
Additional file 3 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 3: Additional Figure 2. Differences in bacterial abundance between metagenomic (MTG) and metatranscriptomic (MTT) data. The percentage of reads annotated to the top-20 most abundant genera is presented for both datasets in caries-active (CA) and caries-free (CF) samples. Baseline samples were collected after the washout period.
Single-boson exchange functional renormalization group application to the two-dimensional Hubbard model at weak coupling
Creators: name: Fraboulet, Kilian
name: Heinzelmann, Sarah
name: Bonetti, Pietro M.
name: Al-Eryani, Aiman
name: Vilardi, Demetrio
name: Toschi, Alessandro
name: Andergassen, Sabine
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We illustrate the algorithmic advantages of the recently introduced single-boson exchange (SBE) formulation for the one-loop functional renormalization group (fRG), by applying it to the two-dimensional Hubbard model on a square lattice. We present a detailed analysis of the fermion-boson Yukawa couplings and of the corresponding physical susceptibilities by studying their evolution with temperature and interaction strength, both at half filling and finite doping. The comparison with the conventional fermionic fRG decomposition shows that the rest functions of the SBE algorithm, which describe correlation effects beyond the SBE processes, play a negligible role in the weak-coupling regime above the pseudo-critical temperature, in contrast to the rest functions of the conventional fRG. Remarkably, they remain finite also at the pseudo-critical transition, whereas the corresponding rest functions of the conventional fRG implementation diverge. As a result, the SBE formulation of the fRG flow allows for a substantial reduction of the numerical effort in the treatment of the two-particle vertex function, paving a promising route for future multiboson and multiloop extensions.
Type Variability and Completeness of Interfaces in Java Applications
Creators: name: Abdeen, Hani
name: Shata, Osama
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Interfaces are widely used as central design elements of Java applications. Although interfaces are abstract types similar to abstract classes, the usage of interfaces in Java applications may considerably differ from the usage of abstract classes. Unlike abstract classes, interfaces are meant to enable multiple inheritance in Java programs. Hence, interfaces are meant to encode shared similarities between classes belonging to different class-type hierarchies. Therefore, it is frequent to use interfaces as partial types, where an interface specifies one specific aspect or usage of its implementing classes. In this paper, we investigate interfaces' usage in Java applications from two perspectives. First, we investigate the usage of interfaces as types of classes belonging to different class-type hierarchies (i.e., interface's type variability). Second, we investigate the usage of interfaces as partial types of implementing classes (i.e., interface's type completeness).
Additional file 4 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 4: Additional Figure 3. Differences in bacterial composition at genus level between datasets. (A) Bar graphs show the proportion (%) of the top-20 most abundant members of supragingival plaque microbiota at Baseline (post-washout period) and after Fluoride and Fluoride + Arginine treatments. At each time point, data are shown for the three available datasets (16S rRNA sequencing, shotgun metagenomics [MTG] and RNA sequencing [MTT]). CA and CF individuals are also differentiated. (B) PCA plot of samples from the CA and CF individuals at the three time points using 16S rRNA sequencing or MTG.
ПРОБЛЕМНЫЕ ВОПРОСЫ ТЕРМИНОЛОГИИ ИНСТИТУТА ПРОФИЛАКТИКИ ПРАВОНАРУШЕНИЙ ОБЯЗАТЕЛЬНЫХ ТРЕБОВАНИЙ – ТЕОРИЯ И ПРАКТИКА
Creators: name: Вотченко И.А.
Publisher: name: Образование и право
Year: 2022
Subjects: правонарушение
профилактика правонарушений
деликт
причины
условия
факторы.

description: В статье изложены взгляды автора на некорректное использование в действующем законодательстве терминов, не являющихся активно употребляемыми практическими работниками системы МЧС России. Также, автор считает, что система профилактики правонарушений в РФ делает «первые шаги» и на данном отрезке времени крайне важно обозначить единый понятийный аппарат. Отечественная юриспруденция под термином «правонарушение» подразумевает широкий спектр наказуемых в порядке юридической ответственности деяний и включает все виды проступков и преступлений. Приоритетным направлением деятельности государства в сфере борьбы с преступностью, сокращением числа административных, дисциплинарных и гражданско-правовых деликтов, было, есть и остается профилактическая работа компетентных органов.
Fully solvable finite simplex lattices with open boundaries in arbitrary dimensions
Creators: name: Arkhipov, Ievgen I.
name: Miranowicz, Adam
name: Nori, Franco
name: Özdemir, Şahin K.
name: Minganti, Fabrizio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Finite simplex lattice models are used in different branches of science, e.g., in condensed matter physics, when studying frustrated magnetic systems and non-Hermitian localization phenomena; or in chemistry, when describing experiments with mixtures. An $n$-simplex represents the simplest possible polytope in $n$ dimensions, e.g., a line segment, a triangle, and a tetrahedron in one, two, and three dimensions, respectively. In this work, we show that various fully solvable, in general non-Hermitian, $n$-simplex lattice models {with open boundaries} can be constructed from the high-order field-moments space of quadratic bosonic systems. Namely, we demonstrate that such $n$-simplex lattices can be formed by a dimensional reduction of highly-degenerate iterated polytope chains in $(k>n)$-dimensions, which naturally emerge in the field-moments space. Our findings indicate that the field-moments space of bosonic systems provides a versatile platform for simulating real-space $n$-simplex lattices exhibiting non-Hermitian phenomena, and yield valuable insights into the structure of many-body systems exhibiting similar complexity. Amongst a variety of practical applications, these simplex structures can offer a physical setting for implementing the discrete fractional Fourier transform, an indispensable tool for both quantum and classical signal processing.
description: 16 pages
Minimal surfaces and entanglement entropy in anti-de Sitter space
Creators: name: Krtous, Pavel
name: Zelnikov, Andrei
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: According to Ryu and Takayanagi, the entanglement entropy in conformal field theory (CFT) is related through the AdS/CFT correspondence to the area of a minimal surface in the bulk. We study this holographic geometrical method of calculating the entanglement entropy in the vacuum case of a CFT which is holographically dual to empty anti-de Sitter (AdS) spacetime. Namely, we investigate the minimal surfaces spanned on boundaries of spherical domains at infinity of hyperbolic space, which represents a time-slice of AdS spacetime. We consider a generic position of two spherical domains: two disjoint domains, overlapping domains, and touching domains. In all these cases we find the explicit expressions for the minimal surfaces and the renormalized expression for the area. We study also the embedding of the minimal surfaces into full AdS spacetime and we find that for a proper choice of the static Killing vector we can model a dynamical situation of "tearing" of the minimal surface when the domains on which it is spanned are moved away from each other.
description: 36 pages, 21 figures, for version with high-resolution figures see http://utf.mff.cuni.cz/~krtous/papers/
Additional file 5 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 5: Additional Figure 4. Number of species and genes detected (N), Chao1 and ACE richness indexes and Shannon diversity index for each study group. Data are shown for all three available datasets (16S rRNA sequencing, shotgun metagenomics [MTG] and RNA sequencing [MTT]). Baseline samples were collected after the washout period. Those comparisons which were significant (p<0,05) according to Wilcoxon test are indicated with *.
Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo
Creators: name: Morgan, Kaye S.
name: Siu, Karen K. W.
name: Parsons, David W.
name: Boucher, Richard C.
name: Stahr, Charlene S.
name: Fouras, Andreas
name: Donnelley, Martin
name: Farrow, Nigel R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray imaging (PCXI) to non-invasively measure the transit rate of individual micron-sized particles deposited into the airways of live mice. The aim of this study was to image changes in MCT produced by a rehydrating treatment based on hypertonic saline (HS), a current CF clinical treatment. Live mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic saline; or no treatment, using a nebuliser integrated within a small-animal ventilator circuit. Marker particle motion was tracked for 20 minutes using PCXI. There were statistically significant increases in MCT in the isotonic and HS-P308 groups. The ability to quantify in vivo changes in MCT may have utility in pre-clinical research studies designed to bring new genetic and pharmaceutical treatments for respiratory diseases into clinical trials.
Oral iron acutely elevates bacterial growth in human serum
Creators: name: Cerami, Carla
name: Fulford, Anthony J.
name: Wegmüller, Rita
name: Cross, James H.
name: Prentice, Andrew M.
name: Jallow, Amadou T.
name: Bradbury, Richard S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Iron deficiency is the most common nutrient deficiency worldwide and routine supplementation is standard policy for pregnant mothers and children in most low-income countries. However, iron lies at the center of host-pathogen competition for nutritional resources and recent trials of iron administration in African and Asian children have resulted in significant excesses of serious adverse events including hospitalizations and deaths. Increased rates of malaria, respiratory infections, severe diarrhea and febrile illnesses of unknown origin have all been reported, but the mechanisms are unclear. We here investigated the ex vivo growth characteristics of exemplar sentinel bacteria in adult sera collected before and 4 h after oral supplementation with 2 mg/kg iron as ferrous sulfate. Escherichia coli, Yersinia enterocolitica and Salmonella enterica serovar Typhimurium (all gram-negative bacteria) and Staphylococcus epidermidis (gram-positive) showed markedly elevated growth in serum collected after iron supplementation. Growth rates were very strongly correlated with transferrin saturation (p < 0.0001 in all cases). Growth of Staphylococcus aureus, which preferentially scavenges heme iron, was unaffected. These data suggest that even modest oral supplements with highly soluble (non-physiological) iron, as typically used in low-income settings, could promote bacteremia by accelerating early phase bacterial growth prior to the induction of immune defenses.
ПРОБЛЕМЫ КВАЛИФИКАЦИИ ПРЕСТУПЛЕНИЯ ПРИ ДАЧЕ ВЗЯТКИ В КРИПТОВАЛЮТЕ
Creators: name: Тарновский А.А.
name: Коваленко Е.В.
name: Мазняк В.К.
Publisher: name: Образование и право
Year: 2022
Subjects: уголовное право
криптовалюта
взятка
правовой статус
суды
размер взятки.

description: В данной статье рассмотрены вопросы, касающиеся определения правового статуса криптовалюты в российском праве, возможность криптовалюты выступать в качестве предмета преступления, способы определения размера взятки, полученной в криптовалюте. Затрагивается вопрос необходимости внедрения положений, регламентирующих использование цифровой валюты, в частности, криптовалюты.
ПРОБЛЕМЫ ПРАВОВОГО РЕГУЛИРОВАНИЯ РАДИОЧАСТОТНОГО СПЕКТРА НА ТЕРРИТОРИИ КЫРГЫЗСКОЙ РЕСПУБЛИКИ
Creators: name: Муслимов Ш.Р.
Publisher: name: Образование и право
Year: 2022
Subjects: радиочастотный спектр
радиочастотный ресурс
закон
сотовая связь
использование радиочастотного ресурса.

description: В представленной статье освещаются существующие проблемы правового регулирования радиочастотного спектра на территории Кыргызской Республики Отмечается, что все проблемные аспекты в заявленной области связаны с неполнотой правового регулирования, так как в действующем законодательстве КР не дается определений основных понятий, что преимущественно не характерно для законодательства иных стран, в которых дается более широкое и полное толкование. На основе анализа законодательства предложено принять и ввести в действие закон «О радиочастотном спектре», так как только указанный нормативно-правовой акт восполнит существующие пробелы и, как следствие, надлежащим образом урегулирует использование радиочастотного спектра в Республике. Оценивается значение радиочастотного спектра для цифровизации и развития страны, формулируется вывод о том, что он необходим для развития сетей сотовой связи, а также для цифрового телевидения, однако программы по развитию данных направлений едва ли будут обладать эффективностью в том случае, если не будет обеспечено надлежащее правовое регулирование заявленной сферы. Основным выводом, к которому приходит автор статьи, состоит в необходимости принятия соответствующего закона.
Pilot Beam Sequence Design for Channel Estimation in Millimeter-Wave MIMO Systems: A POMDP Framework
Creators: name: Seo, Junyeong
name: Sung, Youngchul
name: Lee, Gilwon
name: Kim, Donggun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, adaptive pilot beam sequence design for channel estimation in large millimeter-wave (mmWave) MIMO systems is considered. By exploiting the sparsity of mmWave MIMO channels with the virtual channel representation and imposing a Markovian random walk assumption on the physical movement of the line-of-sight (LOS) and reflection clusters, it is shown that the sparse channel estimation problem in large mmWave MIMO systems reduces to a sequential detection problem that finds the locations and values of the non-zero-valued bins in a two-dimensional rectangular grid, and the optimal adaptive pilot design problem can be cast into the framework of a partially observable Markov decision process (POMDP). Under the POMDP framework, an optimal adaptive pilot beam sequence design method is obtained to maximize the accumulated transmission data rate for a given period of time. Numerical results are provided to validate our pilot signal design method and they show that the proposed method yields good performance.
description: 6 pages, 6 figures, submitted to IEEE ICC 2015
Additional file 6 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 6: Additional Figure 5. Changes in the levels of total and transcriptionally active species caused by toothbrushing with a fluoride toothpaste. Each dot represents a bacterial species that was significantly under- or over-represented in the 16S rRNA sequencing, metagenomic (MTG) or metatranscriptomic (MTT) datasets after 3 months of using a fluoride dentifrice. The abundance (y-axis) and the fold change (x-axis, �fore/�ter) is shown for each bacterial species. Dots corresponding to species over-represented at Baseline are colored in blue and those over-represented after treatment with fluoride are colored in orange. Species differentially represented in caries-active sites (CA) are at the left panels while those for caries-free individuals (CF) are at the right panels.
ПРОБЛЕМЫ ПРАВОГО ПОЛОЖЕНИЯ МАЛЫХ И СРЕДНИХ ИННОВАЦИОННЫХ ПРЕДПРИЯТИЙ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Алексеев Н.С.
Publisher: name: Образование и право
Year: 2022
Subjects: инновационная деятельность
малые и средние инновационные предприятия
инновации
предпринимательская деятельность
модернизация экономики
научно-исследовательские и опытно-конструкторские работы
интеграция в сфере инноватики.

description: Целью настоящей работы является анализ специфики правового регулирования инновационной деятельности малых и средних инновационных предприятиях. Обозначена роль малых и средних инновационных предприятий как одного из ключевых факторов развития и роста экономики Российской Федерации. Описаны проблемы, сдерживающие их развитие, с которыми сталкиваются малые и средние инновационные предприятия во время осуществления своей деятельности. Сформулированы предложения по совершенствованию организационно-правовых мероприятий для решения данных проблем, а также проанализированы действия, предпринимаемые со стороны государства по развитию малого и среднего предпринимательства, занимающихся инновационной деятельностью.
Palladin is Upregulated in Kidney Disease and Contributes to Epithelial Cell Migration After Injury
Creators: name: Jennette, J. Charles
name: Gasim, Adil H.
name: Glaubiger, Samuel A.
name: Otey, Carol A.
name: Chang, Emily H.
name: Kerber, Michael L.
name: Patel, Julie B.
name: Falk, Ronald J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Recovery from acute kidney injury involving tubular epithelial cells requires proliferation and migration of healthy cells to the area of injury. In this study, we show that palladin, a previously characterized cytoskeletal protein, is upregulated in injured tubules and suggest that one of its functions during repair is to facilitate migration of remaining cells to the affected site. In a mouse model of anti-neutrophilic cytoplasmic antibody involving both tubular and glomerular disease, palladin is upregulated in injured tubular cells, crescents and capillary cells with angiitis. In human biopsies of kidneys from patients with other kidney diseases, palladin is also upregulated in crescents and injured tubules. In LLC-PK1 cells, a porcine proximal tubule cell line, stress induced by transforming growth factor-β1 (TGF-β1) leads to palladin upregulation. Knockdown of palladin in LLC-PK1 does not disrupt cell morphology but does lead to a defect in cell migration. Furthermore, TGF-β1 induced increase in the 75 kDa palladin isoform occurs in both the nucleus and the cytoplasm. These data suggest that palladin expression is induced in injured cells and contributes to proper migration of cells in proximal tubules, possibly by regulation of gene expression as part of the healing process after acute injury.
ПРОБЛЕМЫ ПРАВОВОГО РЕГУЛИРОВАНИЯ СОЦИАЛЬНОГО ОБЕСПЕЧЕНИЯ САМОЗАНЯТЫХ
Creators: name: Мироненко Е.И.
Publisher: name: Образование и право
Year: 2022
Subjects: самозанятые
правовой статус
налог на профессиональный доход
социальное обеспечение самозанятых
пенсионное страхование
обязательное медицинское страхование.

description: В статье рассматривается нормативно-правовое регулирование деятельности самозанятых, обращается внимание на трудности правовой регламентации статуса самозанятого. Также поднимается вопрос о недостаточности проработанности проблемы социального обеспечения самозанятых, в том числе в части обязательного пенсионного страхования, обязательного медицинского страхования и других видов социального обеспечения.
Age structure and window collision mortality rate of migratory birds in urban green spaces
Creators: name: Xu, Shang
Publisher: name: No Publisher Supplied
Year: 2024

description: Collision with windows is a major factor of mortality for birds in populated areas. Among bird collision cases, most of them are migratory birds, and we hypothesize that especially inexperienced young birds are affected. To test this prediction, we compared data from an inner-urban migratory bird stopover site located on the Rutgers-Newark Campus in Newark, NJ, and compared the age structure and fitness parameters of mist-netted birds with bird specimens collected as bird-window collision fatalities. In coastal sites, most passerines at stopover during the fall are expected to be juveniles and this study confirms this pattern for an inner-urban stopover site. We found that birds caught in mist-nets and/or collected as mortalities after window collisions are predominantly younger birds. This trend is particularly pronounced in the fall, while in spring, the ratio between younger, first-time returning birds, and older birds is more balanced. We found only slight differences in average fitness conditions between young and old birds. However, as expected, older birds on average were larger (as measured by wing chord length) than younger birds, and birds tended to be heavier and larger in spring than in the fall. When comparing the age structure between the mist-nested birds and the birds obtained in the window collision survey, we observed that the proportion of young birds is higher among birds obtained as bird-window collisions compared to birds caught in mist nets. This supports our hypothesis that overall younger birds are disproportionately more likely to collide with windows than older birds. Our data highlight the vulnerability of juveniles which is an additional threat to the ones also faced by adult birds during stopover in human-dominated landscapes. The higher rate of bird-window collision in younger birds likely is due to the lack of experience compared to older birds which have already completed previous seasonal migrations. However, the mechanisms behind gaining experience and the apparent higher ability of older birds to recognize and avoid glass surfaces are not yet known.
Multiple solutions of steady-state Poisson-Nernst-Planck equations with steric effects
Creators: name: Lin, Tai-Chia
name: Eisenberg, Bob
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Experiments measuring currents through single protein channels show unstable currents. Channels switch between 'open' or 'closed' states in a spontaneous stochastic process called gating. Currents are either (nearly) zero or at a definite level, characteristic of each type of protein, independent of time, once the channel is open. The steady state Poisson-Nernst-Planck equations with steric effects (PNP-steric equations) describe steady current through the open channel quite well, in a wide variety of conditions. Here we study the existence of multiple solutions of steady state PNP-steric equations to see if they themselves, without modification or augmentation, can describe two levels of current. We prove that there are two steady state solutions of PNP-steric equations for (a) three types of ion species (two types of cations and one type of anion) with a positive constant permanent charge, and (b) four types of ion species (two types of cations and their counter-ions) with a constant permanent charge but no sign condition. The excess currents (due to steric effects) associated with these two steady state solutions are derived and expressed as two distinct formulas. Our results indicate that PNP-steric equations may become a useful model to study spontaneous gating of ion channels. Spontaneous gating is thought to involve small structural changes in the channel protein that perhaps produce large changes in the profiles of free energy that determine ion flow. Gating is known to be modulated by external structures. Both can be included in future extensions of our present analysis.
description: 27 pages, 5 figures
Additional file 7 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 7: Additional Figure 6. Presence of arginolytic and non-arginolytic bacteria at the different sample collection times. Bacterial species were separated into argynolytic and non-argynolytic (Non-arcA) according to the presence of the arcA gene. The abundance of each group was calculated at each time point. Data are separately shown for Caries-Active (A) and Caries-Free (B) individuals. Species abundance was normalized by the number of reads (R), by the length (L, in bp) of the gene and by the size of the dataset (in Megabasepairs).
Dimension reduction of noisy interacting systems
Creators: name: Zagli, Niccolò
name: Pavliotis, Grigorios A.
name: Lucarini, Valerio
name: Alecio, Alexander
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We consider a class of models describing an ensemble of identical interacting agents subject to multiplicative noise. In the thermodynamic limit, these systems exhibit continuous and discontinuous phase transitions in a, generally, nonequilibrium setting. We provide a systematic dimension reduction methodology for constructing low dimensional, reduced-order dynamics based on the cumulants of the probability distribution of the infinite system. We show that the low dimensional dynamics returns the correct diagnostic properties since it produces a quantitatively accurate representation of the stationary phase diagram of the system that we compare with exact analytical results and numerical simulations. Moreover, we prove that the reduced order dynamics yields also the prognostic, i.e., time dependent properties, as it provides the correct response of the system to external perturbations. On the one hand, this validates the use of our complexity reduction methodology since it retains information not only of the invariant measure of the system but also of the transition probabilities and time dependent correlation properties of the stochastic dynamics. On the other hand, the breakdown of linear response properties is a key signature of the occurrence of a phase transition. We show that the reduced response operators capture the correct diverging resonant behaviour by quantitatively assessing the singular nature of the susceptibility of the system and the appearance of a pole for real value of frequencies. Hence, this methodology can be interpreted as a low dimensional, reduced order approach to the investigation and detection of critical phenomena in high dimensional interacting systems in settings where order parameters are not known.
description: Accepted Version of the manuscript
Additional file 4 of The usefulness of the total metabolic tumor volume for predicting the postoperative recurrence of thoracic esophageal squamous cell carcinoma
Creators: name: Kaida, Hayato
name: Yasuda, Takushi
name: Shiraishi, Osamu
name: Kato, Hiroaki
name: Kimura, Yutaka
name: Hanaoka, Kohei
name: Yamada, Minoru
name: Matsukubo, Yuko
name: Tsurusaki, Masakatsu
name: Kitajima, Kazuhiro
name: Hattori, Satoshi
name: Ishii, Kazunari
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 4.
Newton-Anderson at Singular Points
Creators: name: Dallas, Matt
name: Pollock, Sara
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65J15

description: In this paper we develop convergence and acceleration theory for Anderson acceleration applied to Newton's method for nonlinear systems in which the Jacobian is singular at a solution. For these problems, the standard Newton algorithm converges linearly in a region about the solution; and, it has been previously observed that Anderson acceleration can substantially improve convergence without additional a priori knowledge, and with little additional computation cost. We present an analysis of the Newton-Anderson algorithm in this context, and introduce a novel and theoretically supported safeguarding strategy. The convergence results are demonstrated with the Chandrasekhar H-equation and some standard benchmark examples.
description: 28 pages, 8 figures; fixed typos, added journal reference
ПРОФОРИЕНТАЦИОННАЯ РАБОТА В РАМКАХ РАННЕЙ ПРОФИЛИЗАЦИИ НА ПРИМЕРЕ ФГБОУ ВО ПРИМОРСКАЯ ГСХА
Creators: name: Костырко А.Н.
name: Семиженова С.Ф.
name: Лосевская О.В.
name: Ландык В.М.
name: Кольцова Л.А.
Publisher: name: Образование и право
Year: 2022
Subjects: обучающиеся
экологическое образование
экологическое воспитание
культура
Приморская государственная сельскохозяйственная академия.

description: В статье проведен анализ основных мероприятий ранней профилизации обучающихся на примере взаимодействия ФГБО ВО Приморская ГСХА и ВДЦ «Океан» в период с 2017 года по настоящее время.
ПУТИ ПРЕОДОЛЕНИЯ ПРАВОВОГО НИГИЛИЗМА В СОВРЕМЕННОЙ РОССИИ
Creators: name: Федоринова Е.А.
Publisher: name: Образование и право
Year: 2022
Subjects: правовое государство
общество
правовая культура
правовой нигилизм
правовая информированность
правовая защищенность.

description: Статья посвящена актуальной на сегодняшний день проблеме распространению идей правового нигилизма в сознании российского общества, которая является препятствием к развитию правового государства в современной России. В статье анализируются причины правового нигилизма, дается характеристика форм его проявления. Подчеркивается важная роль правового воспитания и правового просвещения граждан в целях повышения их правовой культуры. Констатируется, что преодоление правового нигилизма достижимо при создании эффективных гарантий реализации прав и свобод человека, утверждении господства права во всех сферах общественной жизни. Автор в работе предлагает способы преодоления правового нигилизма в современной России.
NTR Synthesised Model of Reflection - Workshops
Creators: name: Wilson, Iain
Publisher: name: Edge Hill University
Year: 2023
Subjects: Higher education
Industrial and organisational psychology (incl. human factors)

description: The Synthesised Model of Reflection (SMoR) is a new model of assessing reflection, which has been piloted at NTU Psychology.
 These are a set of workshops which were used during the pilot to introduce students to the SMoR and guide them through the process. The first workshop is an introduction and discusses how learning from research methods can be applied to reflection to make it a systematic and robust process. The second workshop focuses on identifying appropriate experiences to engage with. The third workshop supports the evaluation and analyses of the experiences. The final workshop provides an opportunity to make sense of the learning in the context of the students' overall development.
 These workshops were piloted with the MSc Occupational Psychology students at NTU Psychology. This pilot was part of a Scholarship sabbatical funded by NTU Psychology.
РОЛЬ ВОСПИТАТЕЛЬНОЙ СРЕДЫ ОБРАЗОВАТЕЛЬНОЙ ОРГАНИЗАЦИИ МВД РОССИИ В СТАНОВЛЕНИИ СПЕЦИАЛИСТА ДЛЯ ОРГАНОВ ВНУТРЕННИХ ДЕЛ
Creators: name: Нимировская Ю.К.
Publisher: name: Образование и право
Year: 2022
Subjects: Воспитание
воспитательная среда
методы
индивидуальный подход.

description: В статье сделан акцент на методах, которые являются условием в решении воспитательных задач, стоящими при профессиональной подготовке специалистов для системы органов внутренних дел. Обосновывается необходимость индивидуального подхода в процессе организации воспитательной работы в университете МВД России.