cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms
Creators: name: Ren, Huiyang
name: Wang, Zhen
name: Zhang, Lei
name: Zhu, Guolian
name: Li, Feng
name: Chen, Bo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1
Can Videos as a By-Product of GUI Testing Help Developers Understand GUI Tests?
Creators: name: Shi, Jianwei
name: Karras, Oliver
name: Obaidi, Martin
name: Tandun, Malvin
Publisher: name: Piscataway, NJ : IEEE
Year: 2023
Subjects: subject: by-product
subject: GUI test
subject: video
subject: Konferenzschrift
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: [Context] Software with graphical user interfaces (GUIs) is used in everyday life. Users expect working software when they interact with a software product. For this reason, testing and defect corrections are required. However, understanding GUI tests is challenging, as the generated textual test reports lack the dynamic details about interaction steps to reproduce a GUI defect. [Objective] We want to revise the practice of GUI testing and use videos as a by-product to capture and convey these dynamic details. [Method] Based on the video as a by-product approach, we propose to generate videos as a by-product of GUI testing, integrating annotations and test outputs directly into the videos. These videos serve as supplementary material for documenting dynamic test executions in addition to static test reports (e.g., texts, screenshots). In an experiment, we asked 11 participants to distinguish between true and false defects in watching videos and screenshots of four test cases. We also conducted structured interviews to ask the participants about their opinions for these two documentation options. [Results & Conclusion] Our results show visible differences between the video and the screenshots in effectiveness and efficiency in defect analysis, but cannot prove the differences statistically. The listed advantages and disadvantages of both documentations are complemental. Both documentations are helpful and thus videos as a by-product of GUI testing can foster the understanding of GUI tests.© 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Long-slit Spectroscopy of Edge-on Low Surface Brightness Galaxies
Creators: name: Du, Wei
name: Wu, Hong
name: Zhu, Yinan
name: Zheng, Weikang
name: Filippenko, Alexei V.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present long-slit optical spectra of 12 edge-on low surface brightness galaxies (LSBGs) positioned along their major axes. After performing reddening corrections for the emission-line fluxes measured from the extracted integrated spectra, we measured the gas-phase metallicities of our LSBG sample using both the [NII]/Ha and the R_23 diagnostics. Both sets of oxygen abundances show good agreement with each other, giving a median value of 12 + log(O/H) = 8.26 dex. In the luminosity-metallicity plot, our LSBG sample is consistent with the behavior of normal galaxies. In the mass-metallicity diagram, our LSBG sample has lower metallicities for lower stellar mass, similar to normal galaxies. The stellar masses estimated from z-band luminosities are comparable to those of prominent spirals. In a plot of the gas mass fraction versus metallicity, our LSBG sample generally agrees with other samples in the high gas mass fraction space. Additionally, we have studied stellar populations of 3 LSBGs which have relatively reliable spectral continua and high signal-to-noise ratios, and qualitatively conclude that they have a potential dearth of stars with ages <1 Gyr instead of being dominated by stellar populations with ages >1Gyr. Regarding the chemical evolution of our sample, the LSBG data appear to allow for up to 30 % metal loss, but we cannot completely rule out the closed-box model. Additionally, we find evidence that our galaxies retain up to about 3 times as much of their metals compared with dwarfs, consistent with metal retention being related to galaxy mass. In conclusion, our data support the view that LSBGs are probably just normal disk galaxies continuously extending to the low end of surface brightness.
description: 48 pages in AAS format, 7 figures, 5 tables, accepted for publication in the ApJ
СЫПИ ПРИ АЛЛЕРГИЧЕСКИХ И НЕАЛЛЕРГИЧЕСКИХ БОЛЕЗНЯХ: АЛГОРИТМ ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКИ
Creators: name: Тарасова Ирина Викторовна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: экзантемы
энантемы
первичные и вторичные морфологические элементы сыпи
инфекционные болезни
аллергические болезни
системные болезни
дифференциальная диагностика

description: Сыпи являются одной из наиболее частых причин обращаемости к врачу. Они представляют собой клинико-морфологические изменения кожи (экзантемы) и слизистых оболочек (энантемы), развивающиеся под влиянием разнообразных эндогенных и экзогенных факторов. Морфологическими элементами сыпи являются высыпания различного характера, подразделяющиеся на первичные (пятно, волдырь, пузырь, гнойничок, узелок, бугорок) и вторичные (гипои гиперпигментации, трещина, чешуйка, эрозия, язва, корочка, рубец). В статье приведены причины и клинические особенности некоторых аллергических и неаллергических болезней, сопровождающихся сыпью, предложен алгоритм их дифференциальной диагностики на основе клинической оценки морфологических элементов, результатов лабораторных исследований и данных эпидемиологического анамнеза.
Enhancing Interpretability of Machine Learning Models for Survival Analysis using Knowledge Graphs
Creators: name: Arnous, Abdulrahman
Publisher: name: Hannover : Gottfried Wilhelm Leibniz Universität
Year: 2024
Subjects: subject: Knowledge Graphs
subject: Survival Analysis
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: [no abstract available]
Cardiovascular mortality trends in non-Hodgkin’s lymphoma: a population-based cohort study
Creators: name: Kamel, Mohamed Gomaa
name: El-Qushayri, Amr Ehab
name: Thach, Tran Quang
name: Nguyen Tien Huy
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Background: Non-Hodgkin’s lymphoma (NHL) survivors are at a higher risk of cardiovascular diseases (CVDs). Methods: A population-based study was conducted to investigate the cardiovascular mortality trends to identify NHL survivors at the highest risk. Results: The CVDs mortality was the second most common cause of death (13.07%) after NHL. There were more patients ≥ 60 years old in the cardiovascular group (87.2%), P Conclusions: Although the CVSS improved over time, the mortality from the CVDs is still the second most common cause of death after NHL. Older age, not married, black, male patients, not recently diagnosed with NHL, with an advanced stage and not receiving radiation and/or surgery were associated with a worse survival. Risk factor modification along with CVDs screening should be intensified in NHL patients with these mortality predictors.
Transitions in Cooperative Labour and the Constraints to the Adoption and Scaling-Up of Labour Intensive Agricultural Technologies
Creators: name: Natcher, David
name: Bachmann, Erika
name: Baco, Mohamed Nasser
name: Kulshreshtha, Suren
name: Pittman, Jeremy
name: Peak, Derek
name: Natcher, David
name: Bachmann, Erika
name: Baco, Mohamed Nasser
name: Kulshreshtha, Suren
name: Pittman, Jeremy
name: Peak, Derek
Publisher: name: Unknown
Year: 2018
Subjects: subject: Labor and Human Capital
subject: Benin
subject: labour exchange
subject: micro-dosing
subject: socio-economic inequality

description: The research presented in this paper stems from a collaboration between researchers in the Benin Republic, Nigeria and Canada who are examining the opportunities to enhance the sustainable production of under-utilized indigenous vegetables through the micro-dosage of synthetic fertilizer. Because micro-dosing is a labour intensive technology, and is time sensitive in application, we sought to better understand how the availability of labour, as affected by changes in cooperative networks, might affect adoption and scaling up opportunities. The systems of cooperative labour described in this paper reflect the culture and traditions of the Betammaribe people, residing in the village of Koumagou B in northwest Benin. Our results indicate that cooperative labour systems among the Betammaribe are in transition and are being influenced by seasonal migration, the financial demands of formal education, the use of oxen by those with relative wealth, and off-farm employment. These pressures have led to the atomizing of Koumagou B households and a concomitant decline in the availability of cooperative labour. Interventions designed to improve the livelihoods of smallholder farmers must not inadvertently perpetuate social and economic inequalities or disadvantage those most vulnerable. It is this possibility that warrants careful consideration as we contemplate the benefits of adopting and scaling-up new agricultural technologies in the future.
УРОВНИ ИНТЕРЛЕЙКИНА-5 В ЗАВИСИМОСТИ ОТ СТЕПЕНИ ТЯЖЕСТИ АТОПИЧЕСКОГО ДЕРМАТИТА
Creators: name: Прилуцкий Александр Сергеевич
name: Ткаченко Ксения Евгеньевна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: атопический дерматит
пищевая аллергия
степень тяжести
корреляция
SCORAD
интерлейкин-5
ИЛ-5

description: Атопический дерматит является одним из наиболее распространенных аллергических заболеваний детского возраста. В ряде исследований сообщается о роли Т-хелперов 2-го типа и синтезируемых ими цитокинов в патогенезе атопического дерматита. Настоящее исследование посвящено изучению возможных связей интерлейкина-5 и тяжести клинических проявлений атопического дерматита. Нами проанкетировано и обследовано 84 пациента, страдающих атопическим дерматитом. Контрольную группу составили 68 здоровых лиц. У всех обследованных произведен подсчет индекса тяжести атопического дерматита SCORAD, определены уровни интерлейкина-5 в сыворотке крови. Проведены сравнения значений интерлейкина-5 в зависимости от степени тяжести атопического дерматита, рассчитан показатель ранговой корреляции Кендалла уровня интерлейкина-5 с индексом SCORAD. Установлено, что уровень вышеуказанного цитокина существенно выше (р<0,001) у обследованных больных атопическим дерматитом по сравнению с аналогичным показателем контрольной группы. Установлено, что уровни интерлейкина-5 достоверно (р=0,014) выше у больных с тяжелым атопическим дерматитом по сравнению с больными, имеющими легкое и среднетяжелое течение заболевания. Также выявлена прямая корреляционная зависимость между индексами тяжести атопического дерматита SCORAD и показателями интерлейкина-5 (р=0,02). Данные нашего исследования подтверждают важность влияния интерлейкина-5 на тяжесть клинических проявлений атопического дерматита.
ОСОБЕННОСТИ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ДЕТЕЙ ГРУПП ЭКОЛОГИЧЕСКОГО РИСКА, АСПЕКТЫ ИХ ИММУННОГО СТАТУСА И ВОЗМОЖНОСТИ ВОССТАНОВИТЕЛЬНОЙ ТЕРАПИИ
Creators: name: Кожин Александр Алексеевич
name: Попова Виктория Александровна
name: Пузикова Олеся Зиновьевна
name: Чурюкина Элла Витальевна
name: Голошубова Елена Александровна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: экологический риск
микроэлементы
иммунный статус
иммуноглобулины
неспецифическая резистентность
восстановительная терапия

description: В работе приводятся результаты исследования содержания ряда химических элементов, гормональных и иммунологических показателей функционального состояния детей из групп экологического риска. Показаны значительные снижения ряда иммунологических и биохимических показателей у детей, имеющих более высокий уровень свинца и сниженное содержание эссенциальных химических элементов в утренней моче. Дети со сниженными концентрациями кортизола и иммуноглобулинов отличались повышенной частотой заболеваемости респираторной системы, что указывало на сниженную неспецифическую резистентность. Установлена перспективность применения комплекса оздоровительных фармакологических и физиотерапевтических методов с целью повышения неспецифической резистентности у детей со сниженным адаптационным ресурсом. Эффективность восстановительной терапии была наилучшей у детей 1-й группы (детей, семьи которых проживали в техногенно загрязненном районе города), что, очевидно, связано с этиологическими особенностями возникновения дисфункций их адаптационных механизмов.
Cardiovascular mortality trends in non-Hodgkin’s lymphoma: a population-based cohort study
Creators: name: Kamel, Mohamed Gomaa
name: El-Qushayri, Amr Ehab
name: Thach, Tran Quang
name: Nguyen Tien Huy
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Background: Non-Hodgkin’s lymphoma (NHL) survivors are at a higher risk of cardiovascular diseases (CVDs). Methods: A population-based study was conducted to investigate the cardiovascular mortality trends to identify NHL survivors at the highest risk. Results: The CVDs mortality was the second most common cause of death (13.07%) after NHL. There were more patients ≥ 60 years old in the cardiovascular group (87.2%), P < 0.001. Patients who died from CVDs had the best survival while patients who died from NHL had a significantly lower mean survival. The overall survival rate was 92.4%. Consistently, older age, unmarried, male patients, not recently diagnosed with NHL and not receiving radiation and/or surgery were associated with a worse survival across all models. The black race and stage IV only had a worse cardiovascular specific survival (CVSS). Conclusions: Although the CVSS improved over time, the mortality from the CVDs is still the second most common cause of death after NHL. Older age, not married, black, male patients, not recently diagnosed with NHL, with an advanced stage and not receiving radiation and/or surgery were associated with a worse survival. Risk factor modification along with CVDs screening should be intensified in NHL patients with these mortality predictors.
ФИЗИЧЕСКИЕ ФАКТОРЫ ПРИ БРОНХООБСТРУКТИВНОМ СИНДРОМЕ У ДЕТЕЙ РАННЕГО ВОЗРАСТА
Creators: name: Конова Ольга Михайловна
name: Давыдова Ирина Владимировна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: бронхообструктивный синдром
дети
физические факторы

description: Бронхообструктивный синдром (БОС) достаточно часто встречается у детей первых трех лет жизни. Длительная медикаментозная терапия БОС может вызывать побочные реакции и способствовать аллергизации организма ребенка. В связи с этим немедикаментозная терапия, оказывая воздействие на различные патогенетические звенья БОС, является важной частью комплексного лечения и реабилитации таких пациентов.
Cost-effectiveness analysis of infliximab, adalimumab, golimumab and vedolizumab for moderate to severe ulcerative colitis in Spain
Creators: name: Trigo-Vicente, Cristina
name: Gimeno-Ballester, Vicente
name: Montoiro-Allué, Raquel
name: Val, Alejandro López-Del
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Objectives: Assess the efficiency of biologic treatment for moderate to severe ulcerative colitis (UC) which are indicated and financed for this pathology by Spain. Methods: A Markov model was constructed to simulate the progression in a cohort of patients with moderate to severe UC. The perspective chosen was National Health Service with an over 10 years of time horizon, with a discount rate of 3%, and established threshold of €30,000/quality-adjusted life-year (QALY). Results: The comparison between infliximab versus adalimumab achieved an incremental cost-effectiveness ratio (ICER) of €45,582/QALY, with a 0.900 QALYs difference of efficacy and an incremental cost of €41,036. Golimumab versus adalimumab reached an ICER of €2,175,992/QALY, with a difference of 0.001 QALY in efficacy and a raising cost to €2,611. The comparison between vedolizumab with adalimumab achieved an ICER of €90,532/QALY, 0.930 QALYs of difference and an increasing cost of €84,218. The probabilistic sensitivity analysis shows that adalimumab would be cost-effective in the 65.2% of the simulations, infliximab in the 18.4%, golimumab in the 16.4% and vedulizumab for the 0%. Conclusions: Among all these drugs studied, adalimumab is the most cost-effective drug for the treatment of moderate to severe UC for a threshold of €30,000/QALY in Spain.
Cost-effectiveness analysis of infliximab, adalimumab, golimumab and vedolizumab for moderate to severe ulcerative colitis in Spain
Creators: name: Trigo-Vicente, Cristina
name: Gimeno-Ballester, Vicente
name: Montoiro-Allué, Raquel
name: Val, Alejandro López-Del
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Objectives: Assess the efficiency of biologic treatment for moderate to severe ulcerative colitis (UC) which are indicated and financed for this pathology by Spain. Methods: A Markov model was constructed to simulate the progression in a cohort of patients with moderate to severe UC. The perspective chosen was National Health Service with an over 10 years of time horizon, with a discount rate of 3%, and established threshold of €30,000/quality-adjusted life-year (QALY). Results: The comparison between infliximab versus adalimumab achieved an incremental cost-effectiveness ratio (ICER) of €45,582/QALY, with a 0.900 QALYs difference of efficacy and an incremental cost of €41,036. Golimumab versus adalimumab reached an ICER of €2,175,992/QALY, with a difference of 0.001 QALY in efficacy and a raising cost to €2,611. The comparison between vedolizumab with adalimumab achieved an ICER of €90,532/QALY, 0.930 QALYs of difference and an increasing cost of €84,218. The probabilistic sensitivity analysis shows that adalimumab would be cost-effective in the 65.2% of the simulations, infliximab in the 18.4%, golimumab in the 16.4% and vedulizumab for the 0%. Conclusions: Among all these drugs studied, adalimumab is the most cost-effective drug for the treatment of moderate to severe UC for a threshold of €30,000/QALY in Spain.
Thermal conductance of a two-level atom coupled to two quantum harmonic oscillators
Creators: name: Guimarães, Pedro H.
name: Landi, Gabriel T.
name: de Oliveira, Mário J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We have determined the thermal conductance of a system consisting of a two-level atom coupled to two quantum harmonic oscillators in contact with heat reservoirs at distinct temperatures. The calculation of the heat flux as well as the atomic population and the rate of entropy production are obtained by the use of a quantum Fokker-Planck-Kramers equation and by a Lindblad master equation. The calculations are performed for small values of the coupling constant. The results coming from both approaches show that the conductance is proportional to the coupling constant squared and that, at high temperatures, it is proportional to the inverse of temperature.
Additional file 1 of RNA-seq analysis reveals changes in mRNA expression during development in Daphnia mitsukuri
Creators: name: Zhang, Xiuping
name: Yang, Wenwu
name: Blair, David
name: Hu, Wei
name: Yin, Mingbo
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1.
РЕПАРАТИВНАЯ ТЕРАПИЯ «МАЛЫХ» РАН С ПОЗИЦИИ ДЕРМАТОЛОГА И КОСМЕТОЛОГА
Creators: name: Тамразова Ольга Борисовна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: раны
повреждения кожи
регенерация
фазы раневого процесса
Дермалибур

description: Важной проблемой в практической деятельности врачей дерматовенерологов и косметологов является восстановление дефектов кожного покрова (малых ран), которые возникают вследствие повреждений различного генеза. Трещины, эрозии, язвы, экскориации могут стать «входными воротами» для инфекции, сопровождаться повышенной кровоточивостью, болевыми ощущениями. Процесс заживления проходит три стадии: воспаление, регенерация и рубцевание. Сокращение времени длительности фаз заживления приводит к быстрой репарации дефектов кожного покрова. Современная терапия повреждений кожи включает в себя основные направления: профилактика и лечение инфицирования, максимально быстрое заживление кожного дефекта, профилактика патологического заживления и косметических дефектов. Современным репарантом является препарат Дермалибур+ (восстанавливающий крем), который сокращает время заживления ран и препятствует развитию на месте повреждения косметических дефектов.
Custom-tailored spatial mode sorting by controlled random scattering
Creators: name: Fickler, Robert
name: Ginoya, Manit
name: Boyd, Robert W.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The need to increase data transfer rates constitutes a key challenge in modern information-driven societies. Taking advantage of the transverse spatial modes of light to encode more information is a promising avenue for both classical and quantum photonics. However, to ease access to the encoded information, it is essential to be able to sort spatial modes into different output channels. Here, we introduce a novel way to customize the sorting of arbitrary spatial light modes. Our method relies on the high degree of control over random scattering processes by preshaping of the phase structure of the incident light. We demonstrate experimentally that various sets of modes, irrespective of their specific modal structure, can be transformed to any output channel arrangement. Thus, our method enables full access to all of the information encoded in the transverse structure of the field, for example, azimuthal and radial modes. We also demonstrate that coherence is retained in this complex mode transformation, which opens up applications in quantum and classical information science.
description: 5 pages, 5 figures
АТОПИЧЕСКИЙ ДЕРМАТИТ У ДЕТЕЙ: СОВРЕМЕННЫЕ ПРИНЦИПЫ ПРОТИВОВОСПАЛИТЕЛЬНОЙ ТЕРАПИИ
Creators: name: Зайнуллина Олеся Николаевна
name: Печкуров Дмитрий Владимирович
name: Хисматуллина Зарема Римовна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: атопический дерматит
дети
наружное лечение
топические глюкокортикостероиды
блокаторы кальциневрина

description: Основой лечения атопического дерматита (АтД) у детей является наружная терапия, направленная на купирование воспаления, зуда, повышения барьерной функции кожи, что должно обеспечить профилактику обострений и присоединения вторичной гнойной инфекции. Цель – изучение эффективности и безопасности комплексного этапного применения негалогенизированного топического глюкокортикостероида и ингибитора кальциневрина в лечении АтД у детей. Материал и методы. Под наблюдением находились 30 детей в возрасте от 2 до 12 лет с АтД среднетяжелой и тяжелой степени в стадии обострения. Всем больным назначалась стандартная системная терапия и местно – комбинированная последовательная терапия: негалогенизированный топический глюкокортикостероид в течении семи дней и далее ингибитор кальциневрина в течение двух недель. Проводилась оценка терапии до лечения, через неделю и через три недели от его начала с помощью индекса SCORAD, опросника ДДИКЖ, уровня увлажненности кожи в очагах поражения, методом оптической когерентной томографии. Основные результаты. Комплексное лечение, включающее последовательное применение препаратов негалогенизированного топического глюкокортикостероида и ингибитора кальциневрина у детей с АтД, является высокоэффективным методом, что подтверждается редукцией индексов SCORAD в 2,9 раза (р<0,05) (41,7 и 14,2 балла), ДДИКЖ – в 2,9 раза (21,1 и 7,3 балла) (р<0,05) , увеличением показателя корнеометрии в 2,6 раза (18,2 и 47,1 ед.) (р<0,05). Заключение. Результатом комплексного лечения АтД среднетяжелой и тяжелой степени в виде последовательного применения негалогенизированного топического глюкокортикостероида и ингибитора кальциневрина явилась положительная динамика состояния кожи.
BrightSpace Project Newsletter / Edition 1 / May 2023
Creators: name: Balazs, Katalin
Publisher: name: BrightSpace Horizon Europe project GA Nr. 101060075
Year: 2023

description: BrightSpace Project Newsletter / Edition 1 / May 2023

This is the first issue of the BrightSpace project newsletter, from which one can get to know:

What BrightSpace is all about?

Which organisations are in the project team?

How is the project structured?

What are the latest developments in our project?

Where and how are we networking and cooperate with other Horizon Europe Projects?

What are the upcoming international events where you can meet us? 

Further information

BrightSpace Project coordination: Wageningen Economic Research, The Hague, NLContact: brightspace.wecr@wur.nl | Website: www.brightspace-project.eu

Project duration: 1 November 2022 – 31 October 2027

Funded by the European Union. Horizon Europe Grant Agreement No. 101060075. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the granting authority can be held responsible for them.

UKRI Project code: 10047415
A critical analysis of literature reviews on conversational AI in language learning (CoALL)
Creators: name: Fryer, Luke K.
name: Huang, Weijiao
name: Yang, Xinyuan
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Education
subject: Artificial Intelligent
subject: CALL
subject: Conversational AI

description: This is a registration of a protocol for a meta-review that aims to provide a consolidated overview regarding how current reviews discuss conversational AI in language learning, from which we summarize the findings across various reviews to highlight overarching trends and implications in this field.
ОСОБЕННОСТИ ТЕРАПИИ АЛЛЕРГИЧЕСКОГО РИНИТА У ДЕТЕЙ, ПРОТЕКАЮЩЕГО В УСЛОВИЯХ КОЛОНИЗАЦИИ ГРИБАМИ РОДА CANDIDA
Creators: name: Маланичева Татьяна Геннадьевна
name: Агафонова Елена Валентиновна
name: Зиатдинова Нелли Валентиновна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: аллергический ринит
грибы рода Candida
местная антимикотическая и иммуномодулирующая терапия

description: Цель работы – совершенствование методов лечения аллергического ринита (АР), протекающего в условиях колонизации грибами рода Candida, у детей. Обследовано 80 детей в возрасте от 3 до 18 лет с АР с бытовой и эпидермальной сенсибилизацией, протекающим в условиях колонизации грибами Candida. Основную группу составили 40 детей, получавшие в составе комлексной противоаллергической терапии местно препарат Октенисепт, обладаюший фунгицидной активностью и иммуномодятор Полиоксидоний. В группу сравнения вошли 40 детей, которым была назначена только традиционная противоаллергическая терапия в зависимости от тяжести течения заболевания, которая не имела различий в сравниваемых группах. Установлено, что у детей основной группы отмечался выраженный положительный краткосрочный и отсроченный клинический эффект. Это выражалось в сокращении периода обострения в 1,6 раза и продления длительности ремиссии в 2,4 раза. Проводимая терапия способствовала не только снижению активности аллергического воспаления в слизистой оболочке носовой полости, что потвержалось уменьшением маркеров атопического типа реагирования: числа эозинофилов и уровней секреторного IgE и IL-4 в назальном секрете, но и активации показателей местой противоинфекционной защиты с усилением выработки IFNγ, секреторного IgА и повышением функциональной активности нейтрофилов.
The late Pleistocene origin of the Italian and Maltese populations of Potamon fluviatile (Malacostraca: Decapoda): insights from an expanded sampling of molecular data
Creators: name: L. Vecchioni
name: A. Deidun
name: J. Sciberras
name: A. Sciberras
name: F. Marrone
name: M. Arculeo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology

description: Evidence available for most inland water and terrestrial organisms highlights the significant role played by southern Italy, Sicily and the Maltese islands as refuges during Pleistocene climatic fluctuations. However, to date, the hypothesis that these areas may have acted as Pleistocene refugia for the freshwater crab Potamon fluviatile has not been explicitly tested, and a recent origin of local P. fluviatile populations was proposed on the basis of a small set of analysed molecular data. We have thus expanded the currently available data set on the population genetic structure of P. fluviatile through dedicated samplings in Sicily (Italy, 18 specimens), the Maltese Islands (Malta, 15 specimens) and the island of Corfu (Greece, seven specimens), with the explicit aim of testing the role of southern Italy, Sicily and the Maltese archipelago as refugia where early Pleistocene or pre-Quaternary populations of the freshwater crab could have persisted to date. Based on the analysis of both novel and published cytochrome c oxidase subunit I (COI) sequence data, we gathered evidence supporting a recent origin of the southern Italian, Sicilian and Maltese populations of Potamon fluviatile from the Balkans, thus rejecting the hypothesised Pleistocene persistence in the area of pre-existing local populations of the same species.
Bayesian regression of piecewise homogeneous Poisson processes
Creators: name: Sevilla, Diego
Publisher: name: arXiv
Year: 2017
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: In this paper, a Bayesian method for piecewise regression is adapted to handle counting processes data distributed as Poisson. A numerical code in Mathematica is developed and tested analyzing simulated data. The resulting method is valuable for detecting breaking points in the count rate of time series for Poisson processes.
description: 6 pages, 4 figures
ОСОБЕННОСТИ ТЕЧЕНИЯ ВТОРИЧНЫХ ЗАБОЛЕВАНИЙ ПРИ ВИЧ-ИНФЕКЦИИ У ДЕТЕЙ
Creators: name: Борисова Ольга Вячеславовна
name: Бородулина Елена Александровна
name: Еременко Екатерина Павловна
name: Аристова Дарья Николаевна
name: Теряева Мария Алексеевна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: ВИЧ-инфекция
вторичные заболевания
дети

description: Изучены вторичные заболевания (вирусные, паразитарные и грибковые инфекции) у 124 детей с ВИЧинфекцией. Определена частота их встречаемости в зависимости от стадии ВИЧ-инфекции, наличия или отсутствия иммунодефицита; основные клинические особенности течения. Выявлено преобладание герпетических инфекций, чаще протекающих латентно с бессимптомным носительством вируса.
Measuring re-election prospects across electoral systems: a general approach applied to Germany
Creators: name: Stoffel, Michael F.
name: Sieberer, Ulrich
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Science Policy

description: This research note presents a general approach for measuring the electoral safety of individual MPs across electoral systems that is based on predicted re-election probabilities estimated from multilevel logistic regression models. In contrast to existing measures, this method yields estimates on an intuitive and readily comparable probability scale, captures the higher sensitivity of re-election prospects to electoral change in the range of close races, and can accommodate regional differences in context conditions such as volatility. The paper implements the approach for two archetypical electoral systems – first-past-the-post (FPTP) systems and closed-list proportional representation (PR) – and estimates re-election prospects for the FPTP and PR tiers of the German mixed electoral system in all Bundestag elections since 1957. While the empirical data presented here is mainly illustrative, the concluding section highlights various questions that future research can address with the new measure.
Direct Evidence of Two Superconducting Gaps in FeSe$_{0.5}$Te$_{0.5}$: SnS-Andreev Spectroscopy and Lower Critical Field
Creators: name: Kuzmicheva, T. E.
name: Kuzmichev, S. A.
name: Sadakov, A. V.
name: Muratov, A. V.
name: Usoltsev, A. S.
name: Martovitsky, V. P.
name: Shipilov, A. R.
name: Chareev, D. A.
name: Mitrofanova, E. S.
name: Pudalov, V. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present direct measurements of the superconducting order parameter in nearly optimal FeSe$_{0.5}$Te$_{0.5}$ single crystals with critical temperature $T_C \approx 14$ K. Using intrinsic multiple Andreev reflection effect (IMARE) spectroscopy and measurements of lower critical field, we directly determined two superconducting gaps, $Δ_L \approx 3.3 - 3.4$ meV and $Δ_S \approx 1$ meV, and their temperature dependences. We show that a two-band model fits well the experimental data. The estimated electron-boson coupling constants indicate a strong intraband and a moderate interband interaction.
ТЯЖEЛАЯ БРОНХИАЛЬНАЯ АСТМА У ДЕТЕЙ
Creators: name: Зайцева Светлана Владимировна
name: Зайцева Ольга Витальевна
name: Локшина Эвелина Эдуардовна
name: Застрожина Анастасия Константиновна
name: Муртазаева Ольга Анатольевна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: тяжелая бронхиальная астма
дети

description: Тяжелая, трудно контролируемая бронхиальная астма у детей до настоящего времени остается серьезной проблемой в педиатрии и детской аллергологии. Заболевание существенно снижает качество жизни пациентов, членов их семей и значительно увеличивает фармако-экономические затраты здравоохранения на лечение заболевания. По данным GINA-2019, 24% пациентов используют объем терапии, соответствующий тяжелой БА, из них у 17% пациентов удается установить факторы, определяющие низкую контролируемость симптомов заболевания. Среди этих факторов основными являются: низкая приверженность терапии, плохой комплаенс, ошибки техники использования препаратов, сопутствующих заболеваниям, а в некоторых случаях – неправильная диагностика заболевания. Однако у 3,7% пациентов диагностируется тяжелая рефрактерная к терапии астма. В статье представлены особенности клиники, диагностики и терапии тяжелой бронхиальной астмы у детей.
ОСОБЕННОСТИ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ, ПРОЖИВАЮЩИХ В ГОРОДСКИХ И СЕЛЬСКИХ РАЙОНАХ САМАРСКОЙ ОБЛАСТИ
Creators: name: Кулагина Вера Викторовна
name: Козлова Ольга Сергеевна
name: Сухова Елена Викторовна
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2019
Subjects: бронхиальная астма
дети
клиническое исследование
уровень контроля

description: Цель работы: сравнительный анализ клинических проявлений и течения бронхиальной астмы у детей, проживающих в городской и сельской местности Самарской области. Материалы и методы. Нами было проанализировано течение заболевания у 106 городских и 80 сельских детей с диагнозом бронхиальная астма (БА). Оценивались следующие данные: возраст дебюта астмы, степень тяжести и ее динамика, причины обострений и приступов, характер сенсибилизации и сопутствующая патология. Постановка кожных тестов проводилась с использованием серии бытовых, эпидермальных, грибковых и пыльцевых аллергенов. Статистическую обработку данных проводили при помощи пакета программ Statistica 7,0. Значимость различий между группами рассчитана с помощью критерия Манна-Уитни. Результаты. У детей с БА, проживающих в сельских районах, легкое течение заболевания встречалось достоверно чаще, чем у городских детей: 82,5 и 54,8%, соответственно. Обострения БА с различной частотой встречались у всех городских пациентов, у 25,0% сельских детей за прошедший год обострений не было. У детей, проживающих в городе, на возникновение приступов БА достоверно чаще оказывают влияние физическая нагрузка, эмоции, резкие запахи и метеофакторы. Заключение. Обострения БА у городских детей возникают достоверно чаще на фоне респираторных заболеваний по сравнению с сельскими детьми. Актуальной является профилактика респираторных заболеваний как триггеров обострений БА у городских детей. У городских детей достоверно чаще, чем у сельских детей, встречались аллергический ринит, пищевая аллергия и сенсибилизация к грибковым и бытовым аллергенам. У всех сельских детей выявлена неправильная техника ингаляции, у 10% детей не было базисной терапии, что требует увеличения времени приема для них.
Additional file 1 of Long-term nitrogen deposition enhances microbial capacities in soil carbon stabilization but reduces network complexity
Creators: name: Ma, Xingyu
name: Wang, Tengxu
name: Shi, Zhou
name: Chiariello, Nona R.
name: Docherty, Kathryn
name: Field, Christopher B.
name: Gutknecht, Jessica
name: Gao, Qun
name: Gu, Yunfu
name: Guo, Xue
name: Hungate, Bruce A.
name: Lei, Jiesi
name: Niboyet, Audrey
name: Le Roux, Xavier
name: Yuan, Mengting
name: Yuan, Tong
name: Zhou, Jizhong
name: Yang, Yunfeng
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Comparison of taxonomic and functional β-diversity between and within treatments. Table S2. Effects of N deposition on microbial taxonomic and functional diversity, as assessed by Shannon index. Table S3. Significantly changed representative OTUs calculated by difference analyses. Table S4. Topological properties of microbial functional gene networks. Table S5. Summary of soil and vegetation attributes in control and N deposited samples. Table S6. Mantel tests for correlations between a range of environmental attributes and quantitative measures of microbial community dissimilarity. Fig. S1. Comparison of the percentage change by N deposition for (a) microbial phyla; (b) N cycling genes; and (c) C cycling genes between using 32 and 4 samples as biological replicates. Fig. S2. The percentage change in relative abundances of microbial class induced by long-term N deposition. Asterisks indicate significant differences. *, P < 0.050; **, P < 0.010. Fig. S3. The percentage change in the relative abundance of major microbial genera induced by long-term N deposition treatment. All selected genera are significantly changed by N deposition treatment as calculated by the response ratio analysis. Fig. S4. The percentage change in the relative abundance of genes associated with C fixation induced by N deposition, calculated as 100*(( mean value in N deposited samples/mean value in control samples) – 1). Mean values and standard deviations are presented. Asterisks indicate significant differences. *, P < 0.050; **, P < 0.010. The numbers in the figure represent the pathways of C fixation. (i) 3-hydroxypropionate bicycle, (ii) Bacterial microcompartments, (iii) Calvin cycle, and (iv) Reductive tricarboxylic acid cycle. Fig. S5. The percentage change in the relative abundance of genes associated with methane and phosphorus cycling genes induced by N deposition, calculated as 100*((mean value in N deposited samples/mean value in control samples) – 1). Mean values and standard deviations are presented. Asterisks indicate significant differences. *, P < 0.050; **, P < 0.010. Fig. S6. N deposition effects on amoA gene. The relative abundance of amoA is presented as the signal intensity difference between control and N deposited samples. Error bars represent standard errors. Blue bars represent genes derived from archaea (AOA), and pink bars represent genes derived from bacteria (AOB). Asterisks indicate significant differences. *, P < 0.050; **, P < 0.010.
Additional file 1 of Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease
Creators: name: Chen, Zhaoting
name: Jiang, Xinying
name: Wu, Jingcan
name: Lin, Lin
name: Zhou, Zhengping
name: Li, Man
name: Wang, Cheng
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Molecular Biology
Biotechnology
Marine Biology
Science Policy

description: Supplementary Material 1.
Observations of Binary Stars with the Differential Speckle Survey Instrument. VII. Measures from 2010 September to 2012 February at the WIYN Telescope
Creators: name: Horch, Elliott P.
name: Casetti-Dinescu, Dana I.
name: Camarata, Matthew A.
name: Bidarian, Akbar
name: van Altena, William F.
name: Sherry, William H.
name: Everett, Mark E.
name: Howell, Steve B.
name: Ciardi, David R.
name: Henry, Todd J.
name: Nusdeo, Daniel A.
name: Winters, Jennifer G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report on speckle observations of binary stars carried out at the WIYN Telescope over the period from September 2010 through February 2012, providing relative astrometry for 2521 observations of 883 objects, 856 of which are double stars and 27 of which are triples. The separations measured span a range of 0.01 to 1.75 arc seconds. Wavelengths of 562 nm, 692 nm, and 880 nm were used, and differential photometry at one or more of these wavelengths is presented in most cases. Sixty-six components were resolved for the first time. We also estimate detection limits at 0.2 and 1.0 arc seconds for high-quality observations in cases where no companion was seen, a total of 176 additional objects. Detection limits vary based on observing conditions and signal-to-noise ratio, but are approximately 4 magnitudes at 0.2 arc seconds and 6 magnitudes at 1.0 arc seconds on average. Analyzing the measurement precision of the data set, we find that the individual separations obtained have linear measurement uncertainties of approximately 2 mas, and photometry is uncertain to approximately 0.1 magnitudes in general. This work provides fundamental, well-calibrated data for future orbit and mass determinations, and we present three first orbits and total mass estimates of nearby K-dwarf systems as examples of this potential.
Reconstructing networks of pulse-coupled oscillators from spike trains
Creators: name: Cestnik, Rok
name: Rosenblum, Michael
Publisher: name: arXiv
Year: 2017
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: We present an approach for reconstructing networks of pulse-coupled neuron-like oscillators from passive observation of pulse trains of all nodes. It is assumed that units are described by their phase response curves and that their phases are instantaneously reset by incoming pulses. Using an iterative procedure, we recover the properties of all nodes, namely their phase response curves and natural frequencies, as well as strengths of all directed connections.
description: 7 pages, 7 figures
INNOVASION MENEJMENT ASOSIDA OLIY TA'LIM MUASSASALARIDA BOSHQARUV XODIMLARINI TAYYORLANING  SHART-SHAROITLARI
Creators: name: Sadullayev, Dilmurod
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada innovasion menejment asosida oliy ta’lim muassasalarida boshqaruv xodimlarini tayyorlashning  shart-sharoitlari yoritilgan. Bilimlarni rivojlantirish va tarqatish shaxslararo muloqot, yuzma-yuz hamkorlik va ijtimoiy faollikni talab qiladi. Bu faoliyatlar odatda o‘rganish, jarayonlarning rivojlanishini kuzatish (bajarish orqali o‘rganish), mashq qilish va boshqalar bilan muloqot qilishni o‘z ichiga oladi. Bunday vaziyatda «bilimlarni boshqarish» (KM) va «uzluksiz o‘rganish», «innovasiya», «muloqot», «hamkorlik» va «almashish madaniyati» atamalari bir-biri bilan chambarchas bog‘liq. Son Kimga ko‘ra, KM texnikasi odatda ochiq ifodalanganidan farqli o‘laroq, odamlarning yashirin bilimlarini, ya’ni ular o‘zlari bilan olib yuradigan, nimalarni ko‘rganlari va tajriba orqali qo‘lga kiritadigan narsalarni olishga intilishlar yoritilgan.
A regional model of endogenous growth without scale assumptions
Creators: name: Bond-Smith, Steven
name: McCann, Philip
name: Oxley, Les
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: In this paper we model growth using a scale-neutral approach to innovation allowing differences between regions to emerge due to regional mechanisms. In this model, agglomeration is growth enhancing as the scale effect for innovation arises from greater access to knowledge rather than any assumed scale effects in growth-modelling techniques. Furthermore, entrepreneurs are assumed to choose the location of firms endogenously so as to minimize the costs of innovation, transport and living. The effects of such mechanisms are such that any policies that increase knowledge spillovers between locations will enhance growth and equality, but may be destabilizing for agglomeration.
Gravitational waves from remnant massive neutron stars of binary neutron star merger: Viscous hydrodynamics effects
Creators: name: Shibata, Masaru
name: Kiuchi, Kenta
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Employing a simplified version of the Israel-Stewart formalism of general-relativistic shear-viscous hydrodynamics, we explore the evolution of a remnant massive neutron star of binary neutron star merger and pay special attention to the resulting gravitational waveforms. We find that for the plausible values of the so-called viscous alpha parameter of the order $10^{-2}$, the degree of the differential rotation in the remnant massive neutron star is significantly reduced in the viscous timescale, $\alt 5$\,ms. Associated with this, the degree of non-axisymmetric deformation is also reduced quickly, and as a consequence, the amplitude of quasi-periodic gravitational waves emitted also decays in the viscous timescale. Our results indicate that for modeling the evolution of the merger remnants of binary neutron stars, we would have to take into account magnetohydrodynamics effects, which in nature could provide the viscous effects.
description: 9 pages, 7 figures, PRD accepted. arXiv admin note: text overlap with arXiv:1703.10303