cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biometric and structural ocular manifestations of Marfan syndrome
Creators: name: Gehle, Petra
name: Goergen, Barbara
name: Pilger, Daniel
name: Ruokonen, Peter
name: Robinson, Peter N.
name: Salchow, Daniel J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background To study biometric and structural ocular manifestations of Marfan syndrome (MFS). Methods Observational, retrospective, comparative cohort study in a tertiary referral center on 285 MFS patients and 267 controls. Structural and biometric ocular characteristic were compared. Results MFS eyes were longer (axial length 24.25 ± 1.74 mm versus 23.89 ± 1.31 mm, p < 0.001) and had a flatter cornea than control eyes (mean keratometry 41.78 ± 1.80 diopters (D) versus 43.05 ± 1.51 D, p < 0.001). Corneal astigmatism was greater and the central cornea was thinner in MFS eyes (530.14 ± 41.31 μm versus 547.02 ± 39.18 μm, p < 0.001). MFS eyes were more myopic than control eyes (spherical equivalent -2.16 ± 3.75 D versus -1.17 ± 2.58 D, p < 0.001). Visual acuity was reduced (0.13 ± 0.25 logMAR versus 0.05 ± 0.18 logMAR, p < 0.001) and intraocular pressure was lower in MFS eyes (14.6 ± 3.4 mmHg versus 15.1 ± 3.2 mmHg, p = 0.01). Iris transillumination defects (ITD) were significantly more common in MFS eyes (odds ratio for MFS in the presence of ITD, 3.7). Ectopia lentis (EL) was only present in MFS eyes (33.4%). History of retinal detachment was significantly more common in MFS eyes. Glaucoma was equally common in both groups. Conclusions ITD and EL are most characteristic findings in MFS. ITD and corneal curvature should be studied as diagnostic criteria for MFS. Visual acuity is reduced in MFS. MFS patients need regular eye exams to identify serious ocular complications.
Structure and luminescence of sol-gel synthesized anatase nanoparticles
Creators: name: Hörmann, Ute
name: Kaiser, Ute
name: Albrecht, Martin
name: Geserick, Jasmin
name: Husing, Nicola
Publisher: name: Universität Ulm
Year: 2010
Subjects: subject: TIO2 NANOCRYSTALS
subject: RAMAN-SCATTERING
subject: DDC 540 / Chemistry & allied sciences
subject: Raman effect
subject: Semiconductors
subject: Halbleiter

description: Two samples of mesoporous anatase nanoparticles, prepared by the sol-gel method, were characterised by Cs-corrected high resolution transmission electron microscopy (HRTEM), X-ray powder diffraction (XRD) and Raman spectroscopy. Statistical evaluation of TEM data showed an average diameter of these crystallites of 8.8 nm and 11.1 nm, respectively. Optical spectroscopy by cathodoluminescence (CL) in a scanning electron microscope (SEM) showed free exciton transitions related to the direct and the indirect band gap of anatase TiO2. From the analysis of the excited states of the free excitons an exciton binding energy of 10 meV and a Bohr radius of 2.35 nm is obtained. The small Bohr radius could explain the absence of quantum confinement in the particles presented in this study.
Partial oxidation of methanol to formaldehyde over Sb-Mo oxide catalysts.
Creators: name: Díaz Real, Rafael Alfredo.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Chemical.

description: The kinetics of the vapor phase air oxidation of methanol to formaldehyde over molybdenum oxide catalysts, antimony oxide catalyst, and their mixtures (both supported and unsupported), at atmospheric pressure and different operating conditions, have been studied in a fixed-bed integral reactor heated by a fluidized sand bath. The effect of various process variables, namely the process temperature (T), the ratio of catalysts to feed flow rate or space time (W/F), and the ratio of methanol fed to air (R), on conversion and yield have been determined. A screening study at varying operating conditions was performed to determine the optimum composition of a Sb$\sb2\rm O\sb4$-MoO$\sb3$ mixture. On the basis of this study a catalyst containing 67% $\rm Sb\sb2O\sb4$-33% MoO$\sb3$ was selected for the detailed kinetic study of oxidation of methanol to formaldehyde. The operating conditions studied were as follows: temperature in the range 623 to 698 K, space times from 5 to 50 $\rm g\sb{cat}/mol\sb{CH\sb3OH}h\sp{-1},$ and methanol to air ratios in the range 0.04 to 0.10 mol$\rm\sb{CH\sb3OH}h\sp{-1}/mol\sb{air}h\sp{-1}.$ This catalyst proved to be highly active and selective to formaldehyde formation. Yields up to $\sim$100% were obtained. Best operating conditions found were obtained at a space time of 27.5 for a methanol/air ratio of 0.06 and a temperature of 698 K. The rate equation for the oxidation of methanol to formaldehyde was derived on the basis of a two-stage redox mechanism$$\eqalign{\rm CH\sb3OH\sb{(g)} + S\sb{ox}\ {\buildrel{k\sb1}\over{\to}}\ &\rm HCHO\sb{(g)} + H\sb2O\sb{(g)} + S\sb{red}\cr\rm O\sb{2\sb{(g)}} + &\rm S\sb{red}\ {\buildrel{k\sb2}\over{\to}}\ S\sb{ox}\cr}$$where S$\rm\sb{ox}$ represents an active site of lattice oxygen and S$\rm\sb{red}$ represents a reduced site of lattice oxygen. The rate equation for the temperature of 648 to 698 K which correlated the data was$$\rm r = {k\sb1P\sb{M}\over 1+{k\sb1P\sb{M}\over 2k\sb2P\sb{O\sb2}}}$$where k$\sb1$ and k$\sb2$ are the temperature dependent rate constants of steps one and two. The equations relating k$\sb1$ and k$\sb2$ with temperature were$$\eqalign{&\rm ln\ k\sb1 = -6.4039-{6.9153\times10\sp3\over T}\cr&\rm ln\ k\sb2 = -3.0154 + {1.8809\times10\sp3\over T}\cr}$$ Several spectroscopic and analytical techniques, viz, electron spin resonance (ESR), x-ray diffraction spectroscopy (XRD), scanning electron microscopy (SEM), and adsorption studies were used to characterize the catalysts. The surface are of the catalyst used in the kinetic study was 6.1 m$\sp2$/g as determined by the BET method. A preliminary study of the Sb-Mo oxide mixture (load of $\sim$5 wt%) supported on Y zeolite was also carried out. Maximum yield obtained was comparable to that obtained with pure MoO$\sb3.$ A new catalyst has been developed that gave nearly 100% conversion and 100% yield. The industrial potential of this catalyst is very promising.
Interrelationships between client strength of feeling, in-session client change events, and type of therapy.
Creators: name: Stalikas, Anastassios.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Psychology, Clinical.

description: A growing number of psychotherapy researchers are studying in-session events that signify therapeutic change, process or progress. Similarly, a number of psychotherapy theorists have suggested that client strength of feeling is related to therapeutic change, process and progress. The purpose of the present research was to: (a) examine the relationship between client change events and client strength of feeling, (b) identify what particular levels of client strength of feeling are related to given categories of client change events, and (c) examine the effects that type of therapy may have in the relationship between client change events and client strength of feeling. Judges assessed the occurrence of categories of client change events and the level of client strength of feeling in 982 statements in 10 sessions of client-centered, rational-emotive and experiential therapies. The findings indicated that: (a) there is an overall positive significant relationship between client change events and client strength of feeling; (b) given categories of client change events are significantly related to particular levels of client strength of feeling; and (c) type of therapy is a significant variable in the relationship between client change events and client strength of feeling. These findings have implications for psychotherapeutic practice and also for clinical theory, with especial relevance for the role and meaning of level of strength of feeling, in-session client change, and a practitioner relevant matrix of conducting sessions of therapy on the basis of the research variables. Possible directions for further research were outlined.
Supplementary document for Photonic hyperinterfaces for light manipulations - 4602717.pdf
Creators: name: xu, yadong
name: ZHANG, SHIBIN
name: Chen, Huanyang
name: Cao, Yanyan
name: Gao, Lei
name: HUANG, HAO
name: ZHOU, HONGYAN
name: Ou, Xin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1: the document provides supplementary information to Photonic hyperinterfaces for light manipulations.
Sociometric status and social behaviour of boys with learning disabilities in a special school in Zambia.
Creators: name: Mulenga, Morgan Chanda.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Education, Educational Psychology.

description: The purpose of this study was to compare the sociometric status and social behaviour of boys with different subtypes of learning disabilities in a self-contained special school in Zambia. Participants were 112 Zambian boys, who had previously been identified as having a learning disability. Sociometric status and social behaviour were determined by sociometric choice and sociometric behaviour assessments, respectively, whereas subtypes of LD and aggression and attention deficits were determined based on the scores obtained on the WRAT3 and the IOWA-CTRS, respectively. Results showed that there were no significant differences in sociometric status and social behaviour between boys with arithmetic disabilities (AD), reading disabilities (RD), and both arithmetic and reading disabilities (AD/RD). Many children with AD were actually indistinguishable from children with RD, on the basis of peer reports of social behaviour. The results also showed that children whose learning disabilities were accompanied by aggression and/or attention deficits received more negative nominations from their peers than boys without any of these problems. A number of possible explanations for the lack of AD-RD differences in sociometric status and social behaviour in this study are offered. The findings may have been attenuated because of the special school-setting in which all children displayed atypical patterns of development. It was, however, interesting to note that the behavioral correlates of sociometric status appeared to be the same in this setting as those found with normally-achieving children in Western cultures. Implications and limitations of the present study as well as suggestions for future research are discussed.
An investigation into the phonology-related processes associated with developmental dyslexia.
Creators: name: Kenney, Elaine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Language, Linguistics.

description: Developmental Dyslexia (DD) is a phenomenon which refers to otherwise normal children who experience significant difficulty in reading acquisition. Many studies investigating DD commonly find the same characteristics associated with DD: (1) readers who are reading significantly below age level but whose IQ does not predict this (2) abnormalities associated with speech which may include speech delay or articulation problems (3) a larger number of males are afflicted than females. The present research involves an examination of the phonology-related processes hypothesized to be deficient in a certain sub-group of DDs. These phonological processes include: (1) the storing or encoding of phonological codes (2) the retrieval of phonological codes from long term memory (3) the ability to maintain phonological codes in working memory while blending or synthesizing is ongoing. A deficiency at any one level or at a combination of these levels could disrupt the acquisition of the reading process. (Abstract shortened by UMI.)
Préservation des éléments mélo-théoriques anciens dans la tradition musicale contemporaine de la sevdalinka -- chanson traditionnelle bosniaque
Creators: name: Medinic, Milada
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Education, Music.

description: La sevdalinka, chanson traditionnelle bosniaque, est une représentation simultanément artistique et historique de la Bosnie-Herzégovine. Plus spécifiquement, son contenu musico-littéraire expose précisement le développement culturel et sociopolitique, ancien et actuel, des territoires en question. Ce développement se reflète au niveau des éléments théoriques spécifiques, notamment la constitution tonale et l'instrumentation, la métrique, et les embellissements et l'interprétation, regroupant respectivement 1) les modes grecques, les gammes occidentales et les modes orientaux --- makamlar, 2) le texte, les melostrophes et le rythme et 3) les ornementations, les melismes, la liberté rythmique et l'improvisation. Une analyse musicale, prenant en considération ces éléments, clarifié l'interaction artistique et historique mentionnée initialement. Cette clarification, à un niveau théorique approfondi, provient d'une possible perception de la préservation des éléments mélo-théoriques anciens dans la tradition musicale contemporaine de la sevdalinka. Mots clés : Analyse théorique; Bosnie-Herzégovine; Brada Moriei; Embellissements; Instrumentation; Interprétation; Métrique; Modalité; Sevdah; Sevdalinka; Tonalité
Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies
Creators: name: Juriloff, Diana M.
name: Harris, Muriel J.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis, originate from a failure of the embryonic neural tube to close. Human NTD are relatively common and both complex and heterogeneous in genetic origin, but the genetic variants and developmental mechanisms are largely unknown. Here we review the numerous studies, mainly in mice, of normal neural tube closure, the mechanisms of failure caused by specific gene mutations, and the evolution of the vertebrate cranial neural tube and its genetic processes, seeking insights into the etiology of human NTD. We find evidence of many regions along the anterior–posterior axis each differing in some aspect of neural tube closure—morphology, cell behavior, specific genes required—and conclude that the etiology of NTD is likely to be partly specific to the anterior–posterior location of the defect and also genetically heterogeneous. We revisit the hypotheses explaining the excess of females among cranial NTD cases in mice and humans and new developments in understanding the role of the folate pathway in NTD. Finally, we demonstrate that evidence from mouse mutants strongly supports the search for digenic or oligogenic etiology in human NTD of all types.
Academic Engagement of First Year Student Athletes: University Football as a Serious Leisure Community of Practice
Creators: name: Rothschild-Checroune, Ezechiel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Recreation.

description: Students must engage in communities supportive of academia to achieve success at university. Academic engagement is crucial for success, given that low levels of engagement have been shown to develop risks for a variety of adverse consequences, including absenteeism and dropping out of school. Students with a supportive environment have been shown to have higher levels of academic engagement. The purpose of this research was to use a phenomenological approach to explore how participation in a Serious Leisure (Stebbins, 1992) Community of Practice (Wenger, 1999) affects academic engagement. This research may be practical for coaches, educators, student athletes and researchers aiming to promote student athletes' academic engagement. Semi-structured interviews were conducted with twelve first year student athletes in the University of Ottawa's Gee Gees varsity football program. Results showed that football participation is so demanding that it may inhibit academic engagement. Conversely, football participation has helped individuals enter university, create a new home, integrate into a brotherhood/pseudo-family, develop an identity, time manage wisely, and become academically motivated. Although athletic pressure may be detrimental, the social support from the football program has proven helpful towards academic engagement.
Press release: Annual Meeting of the BrightSpace project, November 5-6, Seville, Spain
Creators: name: Planslab Kft.
name: Wageningen University & Research
Publisher: name: BrightSpace Horizon Europe project GA Nr. 101060075
Year: 2024

description: Press release: Annual Meeting of the BrightSpace project, November 5-6, Seville, Spain

BrightSpace: Designing effective and sustainable strategies for assessing and addressing the challenges of EU agriculture to navigate within a safe and just operating space

05 November 2024

The BrightSpace Project funded under Horizon Europe, a key initiative for operationalizing the concept of Safe and Just Operational Space in EU agriculture, is set to host its Annual Meeting from November 5-6, 2024, at the Torre Sevilla in Seville, Spain. This gathering brings together experts, policymakers, and stakeholders to discuss the project’s progress in promoting sustainable agriculture within the framework of the Safe and Just Operating Space (SJOS). Over two days, the event will address the significant challenges and innovations shaping the future of European agriculture, offering critical insights into how environmental and social sustainability goals can be integrated into EU policies.

Further information

BrightSpace Project coordination: Wageningen Economic Research, The Hague, NLContact: brightspace.wecr@wur.nl | Website: www.brightspace-project.eu

Project duration: 1 November 2022 – 31 October 2027

Funded by the European Union. Horizon Europe Grant Agreement No. 101060075. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the granting authority can be held responsible for them.

UKRI Project code: 10047415
A population of faint low surface brightness galaxies in the Perseus cluster core
Creators: name: Wittmann, Carolin
name: Lisker, Thorsten
name: Tilahun, Liyualem Ambachew
name: Grebel, Eva K.
name: Conselice, Christopher J.
name: Penny, Samantha
name: Janz, Joachim
name: Gallagher, John S.
name: Kotulla, Ralf
name: McCormac, James
Publisher: name: Swinburne
Year: 2024

description: We present the detection of 89 low surface brightness (LSB), and thus low stellar density galaxy candidates in the Perseus cluster core, of the kind named 'ultra-diffuse galaxies', with mean effective V-band surface brightnesses 24.8-27.1 mag arcsec -2 , total V-band magnitudes -11.8 to -15.5 mag, and half-light radii 0.7-4.1 kpc. The candidates have been identified in a deep mosaic covering 0.3 deg 2 , based on wide-field imaging data obtained with the William Herschel Telescope. We find that the LSB galaxy population is depleted in the cluster centre and only very few LSB candidates have half-light radii larger than 3 kpc. This appears consistent with an estimate of their tidal radius, which does not reach beyond the stellar extent even if we assume a high dark matter content (M/L = 100). In fact, three of our candidates seem to be associated with tidal streams, which points to their current disruption. Given that published data on faint LSB candidates in the Coma cluster - with its comparable central density to Perseus - show the same dearth of large objects in the core region, we conclude that these cannot survive the strong tides in the centres of massive clusters.
Supplementary document for Photonic hyperinterfaces for light manipulations - 4602717.pdf
Creators: name: xu, yadong
name: ZHANG, SHIBIN
name: Chen, Huanyang
name: Cao, Yanyan
name: Gao, Lei
name: HUANG, HAO
name: ZHOU, HONGYAN
name: Ou, Xin
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplement 1: the document provides supplementary information to Photonic hyperinterfaces for light manipulations.
Viral and cellular factors contributing to the hematogenous dissemination of human cytomegalovirus via polymorphonuclear leukocytes
Creators: name: Braun, Berenike
name: Laib Sampaio, Kerstin
name: Kuderna, Anna K.
name: Widmann, Miriam
name: Sinzger, Christian
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: human cytomegalovirus
subject: clinical isolates
subject: hematogenous dissemination
subject: herpesvirus entry
subject: entry inhibitors
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Cytomegalovirus
subject: Viral fusion protein inhibitors
subject: Neutrophils
subject: Cytomegalie-Virus

description: Polymorphonuclear leukocytes (PMNs) presumably transmit human cytomegalovirus (HCMV) between endothelial cells in blood vessels and thereby facilitate spread to peripheral organs. We aimed to identify viral components that contribute to PMN-mediated transmission and test the hypothesis that cellular adhesion molecules shield transmission sites from entry inhibitors. Stop codons were introduced into the genome of HCMV strain Merlin to delete pUL74 of the trimeric and pUL128 of the pentameric glycoprotein complex and the tegument proteins pp65 and pp71. Mutants were analyzed regarding virus uptake by PMNs and transfer of infection to endothelial cells. Cellular adhesion molecules were evaluated for their contribution to virus transmission using function-blocking antibodies, and hits were further analyzed regarding shielding against inhibitors of virus entry. The viral proteins pUL128, pp65, and pp71 were required for efficient PMN-mediated transmission, whereas pUL74 was dispensable. On the cellular side, the blocking of the αLβ2-integrin LFA-1 reduced virus transfer by 50% and allowed entry inhibitors to reduce it further by 30%. In conclusion, these data show that PMN-mediated transmission depends on the pentameric complex and an intact tegument and supports the idea of a virological synapse that promotes this dissemination mode both directly and via immune evasion.
Res pretiosa as the church's cultural property: The origin and development of ecclesiastical legislation
Creators: name: Galles, Duane L. C. M
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Religion, History of.

description: Among the rights proclaimed by the Universal Declaration of Human Rights and by article 60 of the Second Vatican Council's pastoral constitution on the Church in the modern world is the right to culture. Implicit in this right is the duty imposed on the public authority to preserve the tangible evidences of culture, cultural property. This study aims at exploring the origins and development of the notion of res pretiosa and asks if res pretiosa has become the cultural property of the Church in the 1983 Code of Canon Law. The term cultural property comes from the civil law. It seems first to have appeared in the 1954 Hague Convention and it has become well developed in international law and, more recently, in Anglo-American common law. Chapter 1 traces the development of this law and summarizes the legislation for the preservation of cultural property internationally and in Britain and the United States. Chapter 2 follows the notion res pretiosa from its locus classicus in the 1468 papal bull Ambitiosae back to its cradle in the Roman law of tutor and ward, where it meant "valuable chattels," and then forward through its adoption in canon law. It also looks at its elaboration there, and its codification in the 1917 Code of Canon Law where it has been narrowed to include only chattels valuable for their artistic, historical or intrinsic worth character and the effects of Vatican II on it. Chapter 3 looks at the notion of res pretiosa as found in the 1983 Code, the 1990 Eastern Code and in the suppletive documents, especially those of the Pontifical Commission for the Preservation of the Church's Cultural Heritage. The chapter concludes with a look at that agency and the other agencies of the Roman Curia having care of the Church's cultural heritage. In the conclusion section the author answers the question whether in the 1983 Code res pretiosa has become the cultural property of the Church. He concludes that, while res pretiosa includes cultural property, the term res pretiosa remains broader than the term "cultural property." He also concludes that it would be desirable for the Supreme Legislator to amend the 1983 Latin Code and 1990 Eastern Code so that the terms res pretiosa might be used identically on both and that term and "cultural property" might become coterminous. He also suggests that the Historic Churches Committees developed by the Bishops of England and Wales and their procedures might usefully be adopted in North America to deal with cases of changes proposed to historic churches.
Requirement for YAP1 signaling in myxoid liposarcoma
Creators: name: Trautmann, Marcel
name: Cheng, Ya‐Yun
name: Jensen, Patrizia
name: Azoitei, Ninel
name: Brunner, Ines
name: Hüllein, Jennifer
name: Slabicki, Mikolaj
name: Isfort, Ilka
name: Cyra, Magdalene
name: Berthold, Ruth
name: Wardelmann, Eva
name: Huss, Sebastian
name: Altvater, Bianca
name: Rossig, Claudia
name: Hafner, Susanne
name: Simmet, Thomas
name: Ståhlberg, Anders
name: Åman, Pierre
name: Zenz, Thorsten
name: Lange, Undine
name: Kindler, Thomas
name: Scholl, Claudia
name: Hartmann, Wolfgang
name: Fröhling, Stefan
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: FUS‐DDIT3
subject: YAP1
subject: DDC 610 / Medicine & health
subject: Liposarcoma, Myxoid
subject: Hippo signaling pathway
subject: Verteporfin
subject: Liposarkom

description: Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin,are driven by theFUS-DDIT3fusion gene encoding an aberrant tran-scription factor. The mechanisms whereby FUS-DDIT3mediatessarcomagenesis are incompletely understood, and strategies toselectively target MLS cells remain elusive. Here we show, using anunbiased functional genomic approach, that FUS-DDIT3-expressingmesenchymal stem cells and MLS cell lines are dependent on YAP1,atranscriptional co-activator and central effector of the Hippo path-way involved in tissue growth and tumorigenesis, and that increasedYAP1activity is a hallmark of human MLS. Mechanistically, FUS-DDIT3promotes YAP1expression, nuclear localization, and transcrip-tional activity and physically associates with YAP1in the nucleus ofMLS cells. Pharmacologic inhibition of YAP1activity impairs thegrowth of MLS cellsin vitroandin vivo. These findings identifyoveractive YAP1signaling as unifying feature of MLS developmentthat could represent a novel target for therapeutic intervention.
PeptiCKDdb—peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease
Creators: name: Krochmal, Magdalena
name: Fernandes, Marco
name: Filip, Szymon
name: Pontillo, Claudia
name: Husi, Holger
name: Zoidakis, Jerome
name: Mischak, Harald
name: Vlahou, Antonia
name: Jankowski, Joachim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The peptiCKDdb is a publicly available database platform dedicated to support research in the field of chronic kidney disease (CKD) through identification of novel biomarkers and molecular features of this complex pathology. PeptiCKDdb collects peptidomics and proteomics datasets manually extracted from published studies related to CKD. Datasets from peptidomics or proteomics, human case/control studies on CKD and kidney or urine profiling were included. Data from 114 publications (studies of body fluids and kidney tissue: 26 peptidomics and 76 proteomics manuscripts on human CKD, and 12 focusing on healthy proteome profiling) are currently deposited and the content is quarterly updated. Extracted datasets include information about the experimental setup, clinical study design, discovery-validation sample sizes and list of differentially expressed proteins (P-value
Predictors and outcomes of interest of continuity of care decisions for older inpatients in acute care settings: a scoping review.
Creators: name: Leinert, Christoph
name: Fotteler, Marina
name: Kocar, Thomas
name: Dhayana.Dallmeier
name: Denkinger, Michael
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Geriatrics
subject: Public Health
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Health Services Research
subject: aged
subject: case management
subject: continuity of care
subject: discharge planning
subject: geriatrics
subject: older adults
subject: outcome measures
subject: predictor
subject: scoping review

description: This is a registration of a protocol for a scoping review that investigates existing research concerning different predictors and outcome measures for appropriateness of continuity of care decisions made in older adult inpatients in acute care settings.
Cytogenetic and FMS-Like Tyrosine Kinase 3 Mutation Analyses in Acute Promyelocytic Leukemia Patients
Creators: name: Yaghmaie, Marjan
name: Alimoghaddam, Kamran
name: Mozdarani, Hossein
name: Ardeshir Ghavamzadeh
name: Hajhashemi, Marjan
name: Mozaffar Aznab
name: Ghaffari, Seyed H.
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
title: Análisis de las características radiológicas de los pacientes ingresados con neumonía y sospecha de gripe a. Comparación entre los casos positivos y negativos
Creators: name: Gómez Estern Aguilar, Carola
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Thorax
subject: Infection

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
El objetivo de este trabajo es determinar si existen diferencias en la radiografía de tórax entre pacientes ingresados con neumonía por gripe A (H1N1) y en los que se sospechó pero tuvieron resultado negativo (NEG) tras la realización de PCR y...
Efficient processing of geospatial mHealth data using a scalable crowdsensing platform
Creators: name: Kraft, Robin
name: Birk, Ferdinand
name: Reichert, Manfred
name: Deshpande, Aniruddha
name: Schlee, Winfried
name: Langguth, Berthold
name: Baumeister, Harald
name: Probst, Thomas
name: Spiliopoulou, Myra
name: Pryss, Rüdiger
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: mHealth
subject: Crowdsensing
subject: Cloud-native
subject: Stream processing
subject: Scalability
subject: DDC 004 / Data processing & computer science
subject: Wireless communication systems in medical care
subject: Tinnitus
subject: Geospatial data
subject: Computer networks Scalability
subject: Architectural design
subject: Ohrgeräusch
subject: Skalierbarkeit

description: Smart sensors and smartphones are becoming increasingly prevalent. Both can be used to gather environmental data (e.g., noise). Importantly, these devices can be connected to each other as well as to the Internet to collect large amounts of sensor data, which leads to many new opportunities. In particular, mobile crowdsensing techniques can be used to capture phenomena of common interest. Especially valuable insights can be gained if the collected data are additionally related to the time and place of the measurements. However, many technical solutions still use monolithic backends that are not capable of processing crowdsensing data in a flexible, efficient, and scalable manner. In this work, an architectural design was conceived with the goal to manage geospatial data in challenging crowdsensing healthcare scenarios. It will be shown how the proposed approach can be used to provide users with an interactive map of environmental noise, allowing tinnitus patients and other health-conscious people to avoid locations with harmful sound levels. Technically, the shown approach combines cloud-native applications with Big Data and stream processing concepts. In general, the presented architectural design shall serve as a foundation to implement practical and scalable crowdsensing platforms for various healthcare scenarios beyond the addressed use case.
title: Impacto del método para contracepción permanente tipo Essure en un Servicio de Diagnóstico por la Imagen
Creators: name: Ruiz Macarrilla, Sonia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Obstruction / Occlusion
subject: Hysterosalpingography
subject: Conventional radiography
subject: Genital / Reproductive system female

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Los objetivos de nuestra revisión de pacientes a las cuales se le ha implantado el método para contracepción permanente tipo Essure®, son: 1) Conocer la naturaleza del dispositivo Essure®. 2) Conocer las indicaciones y técnica de la...
title: Termoablación con microondas, nuestra experiencia desde 2009 (HURH)
Creators: name: BARRAGAN, JOSE IGNACIO
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Metastases
subject: Intraoperative
subject: Ultrasound
subject: Percutaneous
subject: Interventional non-vascular
subject: Abdomen
subject: Liver

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Describir la técnica y principios físicos de la termoablación con microondas (fig.1) Valorar la eficacia,
seguridad,
tolerancia y posibles complicaciones de esta...
Comparing clinical characteristics of pediatric patients with pancreatic diabetes to patients with type 1 diabetes: A matched case-control study
Creators: name: Lanzinger, Stefanie
name: Welters, Alena
name: Thon, Angelika
name: Konrad, Katja
name: Kapellen, Thomas
name: Grulich-Henn, Jürgen
name: Raddatz, Dirk
name: Holl, Reinhard W.
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: pancreatic diabetes
subject: propensity score matching
subject: type 1 diabetes
subject: EXOCRINE PANCREAS
subject: ADOLESCENTS
subject: CHILDREN
subject: MANAGEMENT
subject: GERMANY
subject: 3C
subject: DDC 610 / Medicine & health
subject: Cystic fibrosis
subject: Diabetes mellitus, Type 1
subject: Child
subject: Adolescent
subject: Diabetes mellitus Typ 1
subject: Bauchspeicheldrüse
subject: Mukoviszidose
subject: Kind
subject: Jugend

description: Background: Only few studies have been conducted on pancreatic diabetes and data from large epidemiological studies are missing. Our main objective was to study the most important differences and similarities between pediatric individuals with pancreatic diabetes and type 1 diabetes (T1D). Methods: Patients <20 years of age were identified from the diabetes patient followup registry (DPV). Data of the most recent treatment year between January 2000 and March 2018 were aggregated. Propensity score was used to match individuals with pancreatic diabetes to individuals with T1D. Matching was conducted one-toone by sex, age, diabetes duration, body mass index SD score (BMI-SDS), and migration background. Results: We studied 731 individuals with pancreatic diabetes and 74 460 with T1D. In the matched cohort of 631 pairs, HbA1c was significantly lower in pancreatic diabetes (7.4% [95% confidence interval: 7.2; 7.5%]) compared to T1D patients (8.7% [8.5; 8.8%]). Daily insulin dose (0.80 IU/kg [0.77; 0.84] vs 0.86 IU/kg [0.82; 0.90]) and insulin pump use (13.3% [10.7; 16.4] vs 22.1% [19.0; 25.6%]) were lower in patients with pancreatic diabetes. However, event rates of severe hypoglycemia were similar between pancreatic and T1D patients (8.8 [5.4; 14.2] vs 9.6 [5.9; 15.6] events per 100 patient years). Conclusions: With the use of robust epidemiological data, our study improves the knowledge on clinical characteristics in pediatric individuals with pancreatic diabetes. Moreover, our results serve as a basis to reconsider treatment options and for discussing clinical practice guidelines for patients with this rare medical condition.
Développement de la fonctionnalité QMMM dans DeFT: Application aux calculs des énergies libres
Creators: name: Paradis, Étienne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Chemistry, Physical.

description: Depuis le début des années 1990, il y a eu beaucoup d'articles publiés sur le développement de la méthodologie QM/MM. Ces potentiels hybrides ont permis l'étude de la formation ou de la rupture de liaison pour des réactions en solution et pour des réactions enzymatiques. Dans cette thèse, nous avons interface le programme DeFT, utilisant la fonctionnelle de la densité, avec le module Roar de la suite AMBER. Dans notre fonctionnalité QM/MM, nous avons utilisé une contrainte sur l'atôme connecté (link atom) pour pouvoir redistribuer le gradient de l'atôme connecté sur les atômes réels du système. Ainsi, nous sommes moins affectés par les degrés de liberté additionnels qui sont présent dans le système, lors de l'optimisation de géometrie et de simulation de dynamique moléculaire, que lorsqu'il n'y a aucune contrainte sur les atômes connectés. Pour valider cette fonctionnalité, nous avons optimisé une serie de molécules pour examiner l'effet de la présence d'un atôme connecté sur la distance C-C. Nous avons démontré que l'utilisation de l'atôme connecté apportait une déviation moyenne de 0.020 A. Nous avons également évalue l'affinité de proton pour une série de bases organiques. Ces mesures montrent bien qu'il soit important d'avoir plus qu'un groupement methyle après le groupement fonctionnel pour obtenir une bonne comparaison avec des calculs complètement quantiques. Par la suite, nous avons regardé la stabilité de cinq conformères de la dipeptide Alanine auxquelles nous avons ajouté une hélice alpha de 20 glycines. Dans la deuxième partie de cette thèse, nous avons implémenté dans DeFT la possibilité de faire des trajectoires de dynamique moléculaire qui sont contraintes à suivre un chemin réactionnel prédéfini. Ceci nous a permis d'obtenir le profil d'énergie libre le long du chemin réactionnel en utilisant la méthode de croissance lente. Cette fonctionnalité a été validée avec une série de réactions électrocycliques. Ces différentes simulations ont montré que l'on pouvait obtenir un profil d'énergie libre très lisse mais avec un coût de calcul très élevé. Dans la dernière partie, nous avons optimisé une méthode hybride (AM1/DFT) pour obtenir le profil d'énergie libre d'une réaction. En utilisant la méthode de perturbation thermodynamique non-Boltzmann, il est possible d'obtenir un profil d'énergie libre de niveau de la fonctionnel de la densité en diminuant le temps de calcul par un facteur d'environ 12.
Neo-Domestication of an Interspecific Tetraploid Helianthus annuus × Helianthus tuberous Population That Segregates for Perennial Habit
Creators: name: Kantar, Michael B.
name: Hüber, Sariel
name: Herman, Adam
name: Bock, Dan G.
name: Baute, Greg
name: Betts, Kevin
name: Ott, Matthew
name: Brandvain, Yaniv
name: Wyse, Donald
name: Stupar, Robert M.
name: Rieseberg, Loren H.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Perennial agriculture has been proposed as an option to improve the sustainability of cropping systems, by increasing the efficiency of resource use, while also providing ecosystem services. Neo-domestication, the contemporary domestication of plants that have not previously been used in agriculture, can be used to generate new crops for these systems. Here we explore the potential of a tetraploid (2n = 4x = 68) interspecific hybrid sunflower as a perennial oilseed for use in multifunctional agricultural systems. A population of this novel tetraploid was obtained from crosses between the annual diploid oilseed crop Helianthus annuus (2n = 2x = 34) and the perennial hexaploid tuber crop Helianthus tuberosus (2n = 6x = 102). We selected for classic domestication syndrome traits for three generations. Substantial phenotypic gains were made, in some cases approaching 320%. We also analyzed the genetic basis of tuber production (i.e., perenniality), with the goal of obtaining molecular markers that could be used to facilitate future breeding in this system. Results from quantitative trait locus (QTL) mapping suggest that tuber production has an oligogenic genetic basis. Overall, this study indicates that substantial gains towards domestication goals can be achieved over contemporary time scales.
title: Angio TC de doble energía en extremidades inferiores
Creators: name: Peña Baranda, Borja
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Computer Applications-3D
subject: CT-Angiography
subject: Vascular
subject: Extremities
subject: Arteries / Aorta

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Conocer la técnica del TC-doble energía (o de doble tubo) en el estudio vascular de extremidades inferiores,
así como sus aplicaciones clínicas y sus...
The drama considered as a dynamic program : an analogous comparison and the development of a metamodel to structurize story lines
Creators: name: Schneider, Rolf
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Dramatic theory
subject: Screenplay writing
subject: Communication science
subject: Media theory
subject: Media science
subject: Theater studies
subject: DDC 510 / Mathematics
subject: DDC 700 / Arts
subject: Motion picture authorship
subject: Drama; Technique
subject: Operations research
subject: Bellman, Richard 1920-1984
subject: Dynamic programming
subject: Motion picture plays
subject: Dramaturgie
subject: Drehbuch
subject: Kommunikationswissenschaft
subject: Medientheorie
subject: Medienwissenschaft

description: This paper shall be understood, as an interdisciplinary attempt to combine mathematics, especially the field of Operations Research with the dramatic theory and media science. The approach is, to draw an analogy between a storyline and a dynamic program, described by Richard Bellman with all the needful restriction to draw the comparison. The intention of this approach is, to obtain schemata, to describe and controll the process of script development in the dramatic arts. This paper is the english translation of the german paper: Das Drama in Analogie zu einem dynamischen Programm. Entwicklung eines Metamodells zur Strukturierung szenischer Handlung. DOI: 10.18725/OPARU-2410 https://oparu.uni-ulm.de/xmlui/handle/123456789/2437 First published in: 2009-12-16
Implementation of double immune checkpoint blockade increases response rate to induction chemotherapy in head and neck cancer
Creators: name: Semrau, Sabine
name: Gostian, Antoniu-Oreste
name: Traxdorf, Maximilian
name: Eckstein, Markus
name: Rutzner, Sandra
name: Von Der Grün, Jens
name: Illmer, Thomas
name: Hautmann, Matthias
name: Klautke, Gunther
name: Laban, Simon
name: Brunner, Thomas
name: Tamaskovics, Bálint
name: Frey, Benjamin
name: Zhou, Jian-Guo
name: Geppert, Carol-Immanuel
name: Hartmann, Arndt
name: Balermpas, Panagiotis
name: Budach, Wilfried
name: Gaipl, Udo
name: Iro, Heinrich
name: Fietkau, Rainer
name: Hecht, Markus
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: combined modality therapy
subject: induction therapy
subject: double immune checkpoint inhibition
subject: HPV-positive OPSCC
subject: DDC 610 / Medicine & health
subject: Head and neck neoplasms
subject: Immunotherapy
subject: Antineoplastic agents; Therapeutic use
subject: Organ preservation
subject: Hals-Nasen-Ohren-Tumor
subject: Induktionstherapie
subject: Immuntherapie

description: To determine whether a single dose of double immune checkpoint blockade (induction chemoimmunotherapy (ICIT)) adds benefit to induction single-cycle platinum doublet (induction chemotherapy (IC)) in locally advanced head and neck squamous cell carcinoma (HNSCC), patients treated with cisplatin 30 mg/m2 d1-3 and docetaxel 75 mg/m2 d1 combined with durvalumab 1500 mg fixed dose d5 and tremelimumab 75 mg fixed dose d5 (ICIT) within the CheckRad-CD8 trial were compared with a retrospective cohort receiving the same chemotherapy (IC) without immunotherapy. The endpoint of this analysis was the complete response rate (CR). A total of 53 patients were treated with ICIT and 104 patients with IC only. CR rates were 60.3% for ICIT and 40.3% for IC (p = 0.018). In the total population (n = 157), the most important predictor to achieve a CR was treatment type (OR: 2.21 for ICIT vs. IC; p = 0.038, multivariate analysis). The most diverse effects in CR rates between ICIT and IC were observed in younger (age ≤ 60) patients with HPV-positive OPSCCs (82% vs. 33%, p = 0.176), while there was no difference in older patients without HPV-positive OPSCCs (53% vs. 48%). The analysis provides initial evidence that ICIT could result in higher CR rates than IC. Young patients with HPV-positive OPSCCs may have the greatest benefit from additional immune checkpoint inhibitors.
title: Tumor filodes de mama. Hallazgos en imagen
Creators: name: Barceló Obregón, Joaquim
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: MR-Spectroscopy
subject: MR-Diffusion/Perfusion
subject: Mammography
subject: Breast

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
El tumor Phyllodes (TP) es una lesión fibroepitelial poco frecuente que representa del 0.3 al 1% de los tumores mamarios.
Habitualmente es benigno pero un 15% de los mismos son malignos con invasión local,
recidivas o metástasis hematógenas. La...
title: Carcinoma primario de glándula suprarrenal. Una rara neoplasia abdominal
Creators: name: Awad Breval, Fadia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Presentar los hallazgos radiológicos de los casos de carcinomas adrenales diagnosticados mediante Anatomía Patológica en nuestro...