cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims
Creators: name: Raghava Choudary Palacharla
name: Ramakrishna Nirogi
name: Venkatesham Uthukam
name: Arunkumar Manoharan
name: Ponnamaneni, Ranjith Kumar
name: Ilayaraja Kalaikadhiban
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: 1. Determination of fm, CYP for a compound is critical to assess the potential risk of a drug candidate as a victim of DDI. Several compounds are identified as CYP2B6 substrates, but the fm, CYP2B6 values are not determined quantitatively. 2. Two methods of reaction phenotyping, the chemical inhibition method and metabolism in rCYP enzymes, were used to determine the relative contributions of the enzymes. Chemical inhibition method was also conducted in the presence of BSA (0.5% w/v). 3. The results confirm with the earlier studies concerning the identity of the CYP2B6 enzyme. The fm, CYP2B6 values for artemisinin, bupropion, clopidogrel, ketamine, selegiline, sertraline and ticlopidine were 0.24, 0.28, 0.15, 0.45, 0.46, 0.42 and 0.54, respectively, in HLM determined by chemical inhibition method. The fm, CYP2B6 values for artemisinin, bupropion, clopidogrel, ketamine, selegiline, sertraline and ticlopidine were 0.46, 0.17, 0.15, 0.60, 0.51, 0.66 and 0.77, respectively, in HLM determined by chemical inhibition method in the presence of BSA (0.5% w/v). 4. Bupropion metabolism is majorly mediated by CYP2C19 (0.41) with a minor contribution from CYP2B6 (0.16) in the presence of BSA. Ticlopidine is a time-dependent inhibitor of both CYP2B6 and CYP2C19 that can inhibit the bupropion metabolism by 50–60%.
Access to Justice for Indigenous Peoples in Africa
Creators: Young, Laura A.
Sing'Oei, Abraham Korir
Publisher: name: Columbia University
Year: 2014
Subjects: Indigenous peoples--Politics and government
Indigenous peoples--Civil rights
International law

description: In preparation for the 2014 World Conference on Indigenous Peoples, Indigenous community representatives from across Africa traveled to Nairobi for a conference in December 2012. The participants identified access to justice as a primary concern for Indigenous Peoples in Africa—whether political recognition and participation, criminal justice, or land rights, Indigenous representatives were clear that their communities struggle to access remedies for violations of their rights. This paper provides a broad overview of the situation for access to justice on the continent—from national legal frameworks, to judicial decisions, to regional human rights bodies, to transitional justice mechanisms. While African Indigenous Peoples’ access to justice concerns are similar to those of Indigenous Peoples around the globe, some specific issues emerge in the African context, such as how to understand the very existence of Indigenous Peoples on the continent. Ultimately, the paper makes clear that access to justice for Indigenous Peoples is more a political than legal issue, and that State political will to implement positive decisions in favor of Indigenous rights is one of the primary challenges for Indigenous Peoples.
Access to Justice in Australia-Aboriginal and Torres Strait Islander People's Experience
Creators: Solonec, Tammy
Kiss, Katie
Publisher: name: Columbia University
Year: 2014
Subjects: Aboriginal Australians--Criminal justice system
Torres Strait Islanders--Civil rights
Human rights
Aboriginal Australians--Civil rights
International law

description: This article examines the challenges experienced by Aboriginal and Torres Strait Islander Peoples in accessing justice more broadly in Australia, and it proposes a way forward. It also considers two options that address the overrepresentation of Aboriginal and Torres Strait Islander Peoples within the criminal justice system and the high incarceration rates: justice reinvestment and the inclusion of national justice targets in the ‘Closing the Gap’ policy framework.
Access to Justice for Indigenous Persons with Disabilities: Key Issues and Opportunities
Creators: Pollack, Carol
Publisher: name: Columbia University
Year: 2014
Subjects: subject: People with disabilities
subject: Human rights
subject: Indigenous peoples--Civil rights
subject: Law
subject: FOS: Law
subject: Public health
subject: Indians
subject: Indians of North America

description: In addressing access to justice issues experienced by Indigenous Peoples, the rights and concerns of Indigenous persons with disabilities must be taken into consideration. This is critical both because of the magnitude of the barriers to justice faced by many Indigenous persons with disabilities and because of the number of people impacted. Over 1 billion people, or approximately 15 percent of the world’s population, have disabilities.2 While no global data exists regarding Indigenous persons with disabilities, available statistics show that Indigenous persons are often disproportionately likely to live with a disability in comparison to the general population. Indigenous persons with disabilities frequently experience multiple forms of discrimination and face barriers to the full enjoyment of their rights, based on their Indigenous status and also on disability.
Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims
Creators: name: Raghava Choudary Palacharla
name: Ramakrishna Nirogi
name: Venkatesham Uthukam
name: Arunkumar Manoharan
name: Ponnamaneni, Ranjith Kumar
name: Ilayaraja Kalaikadhiban
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: 1. Determination of fm, CYP for a compound is critical to assess the potential risk of a drug candidate as a victim of DDI. Several compounds are identified as CYP2B6 substrates but the fm, CYP2B6 values are not determined quantitatively 2. Two methods of reaction phenotyping, the chemical inhibition method, and metabolism in rCYP enzymes, were used to determine the relative contributions of the enzymes. Chemical inhibition method was also conducted in the presence of BSA (0.5% w/v) 3. The results confirm with the earlier studies concerning the identity of the CYP2B6 enzyme. The fm, CYP2B6 values for artemisinin, bupropion, clopidogrel, ketamine, selegiline, sertraline, and ticlopidine were 0.24, 0.28, 0.15, 0.45, 0.46, 0.42, and 0.54 respectively in HLM determined by chemical inhibition method. The fm, CYP2B6 values for artemisinin, bupropion, clopidogrel, ketamine, selegiline, sertraline, and ticlopidine were 0.46, 0.17, 0.15, 0.60, 0.51, 0.66, and 0.77 respectively in HLM determined by chemical inhibition method in the presence of BSA (0.5% w/v) 4. Bupropion metabolism is majorly mediated by CYP2C19 (0.41) with a minor contribution from CYP2B6 (0.16) in the presence of BSA. Ticlopidine is a time-dependent inhibitor of both CYP2B6 and CYP2C19 that can inhibit the bupropion metabolism by 50 – 60%
After the August War: A New Strategy for U.S. Engagement with Georgia
Creators: Mitchell, Lincoln A.
Cooley, Alexander A.
Publisher: name: Columbia University
Year: 2010
Subjects: International relations
Diplomatic relations

description: In the coming years, determining and properly structuring the relationship with Georgia will be critical to U.S. interests in the region, as well as to U.S. relations with Russia and Europe. Moreover, the nature of the relationship between Washington and Tbilisi will play a major role in Georgia's future development, which, in turn, will have a significant impact both within Georgia and beyond its borders. This report focuses on neither the origins of the 2008 conflict nor the role of the United States in the run-up to war; instead, it examines possible ways to get the U.S.-Georgia relationship back on track so that shared goals can be achieved. In a healthy U.S.-Georgian relationship, the United States not only would help Georgia develop peacefully and democratically, but would clearly articulate and pursue its own interests in the region.
Contestable Camera Cars: A Speculative Design Exploration of Public AI That Is Open and Responsive to Dispute
Creators: name: Alfrink, Kars
name: Keller, Ianus
name: Doorn, Neelke
name: Kortuem, Gerd
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Artificial Intelligence (cs.AI)
subject: Computers and Society (cs.CY)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Local governments increasingly use artificial intelligence (AI) for automated decision-making. Contestability, making systems responsive to dispute, is a way to ensure they respect human rights to autonomy and dignity. We investigate the design of public urban AI systems for contestability through the example of camera cars: human-driven vehicles equipped with image sensors. Applying a provisional framework for contestable AI, we use speculative design to create a concept video of a contestable camera car. Using this concept video, we then conduct semi-structured interviews with 17 civil servants who work with AI employed by a large northwestern European city. The resulting data is analyzed using reflexive thematic analysis to identify the main challenges facing the implementation of contestability in public AI. We describe how civic participation faces issues of representation, public AI systems should integrate with existing democratic practices, and cities must expand capacities for responsible AI development and operation.
description: Conditionally accepted to CHI 2023
Additional file 4 of Identification of universal and cell-type specific p53 DNA binding
Creators: name: Hafner, Antonina
name: Kublo, Lyubov
name: Tsabar, Michael
name: Lahav, Galit
name: Stewart-Ornstein, Jacob
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Figure S1. Comparison of p53 DNA binding across cell lines and published p53 ChIP-seq datasets. Heatmap showing p53 binding intensity in 8742 locations in the genome in 12 IR treated cell lines (our data, same as Fig. 1c) as well as published datasets (listed in Methods and Table S1). Figure S2. Comparison of p53 levels between IR and Nutlin3A treatments. p53 levels were detected by western blot in MCF7 and UACC257 cells. Cells were either untreated, treated with 5 μM Nutlin3A or 4Gy IR for 2 h. Figure S3. Reproducibility of in vitro measurements of p53 DNA binding and comparison with in vivo binding. (A) Quantitative agreement in binding strength at p53 binding sites between two replicate p53 in vitro IP datasets using different p53 protein preps. (B) UCSC browser shots of three key binding sites for p53 showing agreement between in vitro binding datasets and divergence with in vivo data. Figure S4. Basal gene expression, but not DNA damage induced gene expression, correlates with cell-type specific p53 DNA binding. (A) Boxplots showing the distribution of Pearson’s correlation coefficients of either basal or DNA damage induced fold change of gene expression with p53 binding at the p53 target or variable p53 binding gene sets. (B) Box plots of the fold change of three canonical p53 target genes 3 h after IR. Each dot represents a cell line. CDKN1A/p21 is induced in all cell lines, while MDM2 and BBC3/Puma are cell line dependent. Figure S5. p53 binds to IL1A and IL1B in mesenchymal cell lines. UCSC browser screen shot of the p53 ChIP signal. In A549 cells, p53 binds in the proximity of IL1A/IL1B only after TGFβ treatment. Binding of p53 in this region can also be observed in another mesenchymal, CAL51, but not epithelial, HCT116, cell line. Figure S6. Knockdown of p53 in LOXIMVI cells reduces expression of inflammatory genes. Expression of p53, IL1A, IL1B, and CXCL1 by qPCR in cells treated with p53 siRNA compared to control siRNA (N = 4).
Table 4 from Humans recognize emotional arousal in vocalizations across all classes of terrestrial vertebrates: evidence for acoustic universals
Creators: name: Filippi, Piera
name: Congdon, Jenna V.
name: Hoang, John
name: Bowling, Daniel L.
name: Reber, Stephan A.
name: Pašukonis, Andrius
name: Hoeschele, Marisa
name: Ocklenburg, Sebastian
name: Boer, Bart De
name: Sturdy, Christopher B.
name: Newen, Albert
name: Güntürkün, Onur
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: (A) Values of the GLMMs computed separately for each animal species. For each species included in our stimuli set, we assessed acoustic predictors of humans’ ability to identify the vocalizations expressing higher levels of arousal. Bold type indicate p ≤0.05; degrees of freedom = 1 for all fixed factors. (B) Outcome of AICc ranking for GLMMs computed within each animal species. ∆AICc is the difference in AICc between each model and the best model. The Akaike's weights indicates the relative support that a given model has from the data, compared to other candidate models. Bold type indicates models with the highest power to explain variation in the dependent variable, based on lowest AICc.
Table 1 from Humans recognize emotional arousal in vocalizations across all classes of terrestrial vertebrates: evidence for acoustic universals
Creators: name: Filippi, Piera
name: Congdon, Jenna V.
name: Hoang, John
name: Bowling, Daniel L.
name: Reber, Stephan A.
name: Pašukonis, Andrius
name: Hoeschele, Marisa
name: Ocklenburg, Sebastian
name: Boer, Bart De
name: Sturdy, Christopher B.
name: Newen, Albert
name: Güntürkün, Onur
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Description of the vocalization sample used in our study and, when applicable, of the published studies in which they are described. In column “Non-vocal indicator/s of arousal” we provide references for studies assessing the link between the observed behavior, and physiological or neural response as indicator of arousal state.; * See references for details on methods for acoustic recordings; ** In the hourglass treefrog, aggressive calls are longer than advertisement calls in duration. Leading males produce aggressive calls in order to increase the chance of being heard by the female (19, 20).; *** Medium arousal calls were classified as expressing a relatively higher level of arousal when paired with a call classified as low arousal (suckling context). When paired with a call classified as high arousal (separation context) medium calls were classified as expressing a lower level of arousal.; **** Reported behavioral indicators of high arousal in elephants: lifted ears, raised head, lifted tail, temporin secretion (56-58).
Additional file 1 of A comparison between drug-eluting stent implantation and drug-coated balloon angioplasty in patients with left main bifurcation in-stent restenotic lesions
Creators: name: Hyungdon Kook
name: Joo, Hyung
name: Park, Jae
name: Hong, Soon
name: Yu, Cheol
name: Do-Sun Lim
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 1:Supplemental table 1. Baseline clinical and angiographic characteristics and procedural details after the propensity score matching. Supplemental table 2. Quantitative coronary angiography analysis after the propensity score matching.
Table 3 from Humans recognize emotional arousal in vocalizations across all classes of terrestrial vertebrates: evidence for acoustic universals
Creators: name: Filippi, Piera
name: Congdon, Jenna V.
name: Hoang, John
name: Bowling, Daniel L.
name: Reber, Stephan A.
name: Pašukonis, Andrius
name: Hoeschele, Marisa
name: Ocklenburg, Sebastian
name: Boer, Bart De
name: Sturdy, Christopher B.
name: Newen, Albert
name: Güntürkün, Onur
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: (A) Values of the GLMMs computed across animal species. We assessed acoustic predictors of humans’ ability to identify vocalizations expressing higher levels of arousal across terrestrial tetrapods. Bold type indicate p ≤0.05; degrees of freedom = 1 for all fixed factors. (B) Outcome of AICc ranking for GLMMs computed across animal species. ∆AICc is the difference in AICc between each model and the best model. The Akaike's weights indicates the relative support that a given model has from the data, compared to other candidate models. Bold type indicates models with the highest power to explain variation in the dependent variable, based on lowest AICc.
Web Development Company
Creators: name: Mark, John
Publisher: name: Zenodo
Year: 2020
Subjects: web development
custom website development
web design and development
web app developer
web developers

description: 4 Ace Technologies is an interactive technology, strategy and design consulting company that builds effective web and mobile applications. We make the web and mobile work for business & bring digital experiences to life.We are your full-service digital solutions partner. Our services include web design, web development, custom software development, mobile app development, internet marketing, SEO & more. We are building bridges in web technology in order to connect the client’s goal to reality
 www.4acetech.com
Table 2 from Humans recognize emotional arousal in vocalizations across all classes of terrestrial vertebrates: evidence for acoustic universals
Creators: name: Filippi, Piera
name: Congdon, Jenna V.
name: Hoang, John
name: Bowling, Daniel L.
name: Reber, Stephan A.
name: Pašukonis, Andrius
name: Hoeschele, Marisa
name: Ocklenburg, Sebastian
name: Boer, Bart De
name: Sturdy, Christopher B.
name: Newen, Albert
name: Güntürkün, Onur
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Descriptive table of acoustic values of the low and high arousal vocalizations of each species. For each of the acoustic parameters, namely duration, HNR (Harmonic-to-noise-ratio), F0 (mean fundamental frequency) and SCG (spectral center of gravity) the following values are provided: minimum and maximum, mean, and standard error of the mean. For each parameter we included mean ratio and standard error of the mean for high vs low arousal vocalizations within each trial.
Age-based differences in task switching are moderated by executive control demands
Creators: Eich, Teal S.
MacKay-Brandt, Anna
Stern, Yaakov
Gopher, Daniel
Publisher: name: Columbia University
Year: 2018
Subjects: Brain--Aging
Cognition
Neurology
Perceptual-motor processes

description: Objectives: Recent work has identified different aspects of executive function that may underlie cognitive changes associated with age. The current study used a multifactorial design to investigate age sensitivity in the ability to shift between different task sets and the interaction of this ability with several specific aspects of executive control. Method: A large, well-characterized sample of younger (n = 40) and clinically healthy older (n = 51) adults completed a task switching paradigm in which 3 aspects of executive control were manipulated between subjects: a) sensorimotor demand (the number of distinct stimulus-response options); b) stimulus-level interference (i.e., flanker effects); and c) updating/monitoring (the frequency of task switches). Results: Unique age-related deficits were observed for different aspects of local task switching performance costs and updating/monitoring, but not for interference. Sensorimotor demand was also an important additional factor that interacted with task switching performance. Discussion: Our findings suggest that task switching, coupled with infrequent and unexpected transitions from one task set to another, in the context of high motoric demands, is particularly difficult for older adults.
Age-Based Differences in Task Switching Are Moderated by Executive Control Demands
Creators: Eich, Teal S.
Mackay-Brandt, Anna
Stern, Yaakov
Gopher, Daniel
Publisher: name: Columbia University
Year: 2016
Subjects: Neurology
Aging
Executive functions (Neuropsychology)
Gerontology

description: OBJECTIVES: Recent work has identified different aspects of executive function that may underlie cognitive changes associated with age. The current study used a multifactorial design to investigate age sensitivity in the ability to shift between different task sets and the interaction of this ability with several specific aspects of executive control. METHOD: A large, well-characterized sample of younger (n = 40) and clinically healthy older (n = 51) adults completed a task switching paradigm in which 3 aspects of executive control were manipulated between subjects: a) sensorimotor demand (the number of distinct stimulus-response options); b) stimulus-level interference (i.e., flanker effects); and c) updating/monitoring (the frequency of task switches). RESULTS: Unique age-related deficits were observed for different aspects of local task switching performance costs and updating/monitoring, but not for interference. Sensorimotor demand was also an important additional factor that interacted with task switching performance. DISCUSSION: Our findings suggest that task switching, coupled with infrequent and unexpected transitions from one task set to another, in the context of high motoric demands, is particularly difficult for older adults.
Agrippino Manteo (1884-1947)
Creators: Cavallo, Jo Ann
Publisher: name: Columbia University
Year: 2012
Subjects: Europeans
Biography
Art

description: Agrippino Manteo was initially one of a number of puppeteers who carried on the popular Sicilian tradition of puppetry in the New World beginning with the large wave of Italian immigrants in the 1880s and ’90s. Susan Kalcik points to the existence of puppet theaters in Brooklyn, the Bronx, Manhattan, New Jersey, Chicago, San Francisco,and Cleveland, as well as Rio de Janeiro and Buenos Aires.
America’s Forgotten Minority: Indigenous Youth Perspectives on the Challenges Related to Healthcare Access, Widespread Poverty and Public Misinformation Regarding Native Americans
Creators: Moreno, Marcos A.
Publisher: name: Columbia University
Year: 2019
Subjects: Human rights
Indigenous peoples
Indigenous youth
Indigenous peoples--Health and hygiene
Indigenous peoples--Social conditions

description: Contrary to the beliefs of many Americans, Indigenous Peoples within the United States of America are not a relic confined to the colonial past or Western films. A look at recent history tells us that quite the opposite is true, as Native American populations have seen steady growth into the 21st century, with the most recent data accounting for over 3.7 million Indigenous Peoples, spread out among 567 federally recognized tribes in the United States. Every one of these federally recognized tribes operates as a Nation unto itself, sovereign groups that bear the rights of self-governance and self-determination. It is important to note that, though they share a common identity as Indigenous Peoples, each of these Nations is unique, all with their own histories, customs, cultures, and a wide variety of experiences both past and present. Native Americans are the youngest racial demographic in the United States, with a median age of 28 years old; additionally, 34% of the total population of Indigenous Peoples in the United States are under the age of 18. Education opportunities have only recently become accessible to larger proportions of Native Americans. This suggests that younger generations are those more likely to be college-educated, allowing them to attain useful skills that they can then bring back to Native communities. While Native Americans are still vastly underrepresented in the world of higher education, there have been significant increases over the years in the number of these students at the undergraduate college level and beyond. As a result, many have used their education as a platform to raise awareness for Indigenous causes, as well as helping improve their Native communities.
American Indian Boarding Schools in the United States: A Brief History and Legacy
Creators: Lajimodiere, Denise K.
Publisher: name: Columbia University
Year: 2014
Subjects: Indians of North America--Cultural assimilation
Off-reservation boarding schools
Indians
Indians of North America
History, Modern

description: My interest in American Indian boarding school survivors’ stories evolved from recording my father, and other family members, speaking of their experiences. Stories I never knew existed, because they had all maintained silence on their experiences until I began asking questions. My qualitative interview research study of twenty American Indian boarding school survivors “Stringing Rosaries: A Qualitative Study of Sixteen Northern Plains American Indian Boarding School Survivors,” revealed four major themes, including: a) The participants attending boarding school experienced loss in the form of: loss of identity, language, culture, ceremonies and traditions; loss of self esteem; loneliness due to loss of parents and extended family; feeling of abandonment by parents; feeling lost and out of place when they returned home. b) The participants attending boarding school experienced abuse in the form of: corporal punishment; forced child labor; the Outing program; hunger/malnourished; and sexual and mental abuse. c) The participants experienced unresolved grief: maintaining silence; mental health issues, relationship issues and alcohol abuse. d) The participants expressed ways for healing in the form of: a return to Native spirituality and forgiveness.
Entretien de Yazan Muhammad al-Aytan auprès de Muflih al-Nimr al-Fayez à propos du diwan Methqal à Um al-Amad
Creators: name: al-Aytan, Yazan Muhammad
name: al-Nimr al-Fayez, Muflih
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/FileId-3139
description: Coverage: Um al-Amad, Jordanie
An index to examine the sexual HIV risk of psychiatric service users based on sexual partners
Creators: Norcini Pala, Andrea
McKinnon, Karen
Wall, Melanie M.
Cournos, Francine
Guimaraes, Mark D.
Wainberg, Milton L.
Publisher: name: Columbia University
Year: 2017
Subjects: HIV infections
Psychotherapy patients

description: Numerous studies report higher HIV infection rates among psychiatric patients than in the general population.1 Relative to other HIV-affected populations, they have higher rates of HIV-related risk behaviors in fewer sexual occasions, including multiple partners, partners of unknown or positive HIV status, sex in exchange for money, shelter or goods, and low condom use rates.2 We present a new HIV risk index (RI)3 that takes into account differential risk associated with these factors.
Appointment in Dauria: George Kennan, George Frost, and the Architectural Context
Creators: Brumfield, William Craft
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Voyages and travels

description: In the fall of 1885 George Kennan, together with the artist George Frost, traversed the vast territory of the Transbaikal region as part of a project to collect information on the tsarist penal and exile system in Siberia. This material would form the basis of Kennan's fundamental work, Siberia and the Exile System, published in 1891. Although Kennan was a devoted student of Russian history and culture, the shattering impact of Kennan's descriptions, as well as his active lecture campaigns in support of Russian exiles, would have a significant effect on American perceptions of the tsarist regime. Nonetheless, Siberia and the Exile System is not solely a determined study of the Siberian penal system. In tandem with Kennan's primary purpose, the book has passages that cross into the realm of the travel account, albeit under extreme conditions. It is not my purpose to give commentary on the details of Kennan's trip. That commentary has been provided by other specialists. Rather, my intention is to present a view of the architecture and historical background of the settlements through which Kennan and Frost pass.
Molecular mechanism study of EGFR allosteric inhibitors using molecular dynamics simulations and free energy calculations
Creators: name: Wu, Xiaoyun
name: Guo, Qian
name: Li, Qinlan
name: Wan, Shanhe
name: Li, Zhonghuang
name: Zhang, Jiajie
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology

description: The epidermal growth factor receptor (EGFR) kinase inhibitors Gefitinib, Erlotinib, Afatinib and Osimertinib have been approved for the treatments of non-small cell lung cancer patients harboring sensitive EGFR mutations, but resistance arises rapidly. To date all approved EGFR inhibitors are ATP-competitive inhibitors, highlighting the need for therapeutic agents with alternative mechanisms of action. Allosteric kinase inhibitors offer a promising new therapeutic strategy to ATP-competitive inhibitors. The mutant-selective allosteric EGFR inhibitors EAI045 exhibited higher potency for EGFRL858R&T790M compared to WT, which was also effective in EGFR-mutant models including those harboring the C797S mutation. However, it was not effective as a single-agent inhibitor, and require the co-administration of the anti-EGFR antibody Cetuximab. Further efforts produced a more potent analog JBJ-04-125-02, which can inhibit cell proliferation as a single-agent inhibitor. In the present study, molecular dynamics simulations and free energy calculations were performed and revealed the detailed inhibitory mechanism of JBJ-04-125-02 as more potent EGFR inhibitor. Moreover, the energy difference between HOMO and LUMO calculated by DFT implied the higher interaction of JBJ-04-125-02 than EAI045 in the active site of the EGFR. The identified key features obtained from the molecular modeling enabled us to design novel EGFR allosteric inhibitors. Communicated by Ramaswamy H. Sarma
Asian Motifs in Eighteenth-Century Siberian Church Architecture
Creators: Brumfield, William Craft
Publisher: name: Columbia University
Year: 2009
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Church architecture

description: Russia's engagement with Asian peoples and cultures forms a topic whose boundaries have yet to be thoroughly explored, particularly in the relationship between Russian and Asian architecture. As an artifact demanding significant resources as well as building skills, architecture involves numerous factors related to social, economic, and cultural history. The present article will not attempt to give a detailed examination of this broader topic of Russo-Asian relations, but will point to specific instances, primarily in Siberian church architecture of the eighteenth century, that suggest a Russian receptivity to East Asian ornamentation. It is plausible that the growth of trade between Russia and East Asia (especially China) would have created the possibilities for borrowing in architecture, particularly of decorative motifs that could be disseminated in printed form.
Risk of bleeding associated with BTK inhibitor monotherapy: a systematic review and meta-analysis of randomized controlled trials
Creators: name: Jiang, Dan
name: Song, Zaiwei
name: Hu, Yang
name: Dong, Fei
name: Zhao, Rongsheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health

description: The bleeding risk associated with Bruton’s tyrosine kinase inhibitor (BTKi) monotherapy remains to be understood. This systematic review aims to evaluate BTKi monotherapy related bleeding risk. PubMed, Embase, and CENTRAL were searched up to 5 December 2021. We included randomized controlled trials (RCTs) comparing BTKi monotherapy with control drugs, or comparing different BTKi monotherapies. 10 studies with 3139 patients were included. Ibrutinib (vs. control drugs) significantly increased the risk of overall bleeding and major bleeding (RR = 2.22, 95% CI 1.80–2.75, P < 0.00001; RR = 1.80, 95% CI 1.02–3.18, P = 0.04, respectively). Acalabrutinib (vs. control drugs) had a significantly increased overall bleeding risk (RR = 3.45, 95% CI 2.39–4.99, p < 0.00001). A significant difference was found in overall bleeding between ibrutinib and acalabrutinib (RR = 1.35, 95% CI 1.11–1.64, P = 0.002). Compared to zanubrutinib, ibrutinib tended to increase the risk of major bleeding (RR = 1.55, 95% CI 0.57–4.18, P = 0.39). Ibrutinib and acalabrutinib (vs. control drugs) have a higher risk of bleeding and overall bleeding, respectively. Limited evidence suggests that ibrutinib (vs. acalabrutinib) significantly increases overall bleeding risk, but the differences are not observed in other comparisons.
Assessing ENSO summer teleconnections,  impacts, and predictability in North America
Creators: Jong, Bor-Ting
Ting, Mingfang
Seager, Richard
Publisher: name: Columbia University
Year: 2021
Subjects: Teleconnections (Climatology)
Seasons
Forecasting
Mathematical models--Evaluation

description: During the summer when an El Niño event is transitioning to a La Niña event, the extratropical teleconnections exert robust warming anomalies over the U.S. Midwest threatening agricultural production. This study assesses the performance of current climate models in capturing the prominent observed extratropical responses over North America during the transitioning La Niña summer, based on atmospheric general circulation model experiments and coupled models from the North American Multimodel Ensemble (NMME). The ensemble mean of the SST-forced experiments across the transitioning La Niña summers does not capture the robust warming in the Midwest. The SST-forced experiments do not produce consistent subtropical western Pacific (WP) negative precipitation anomalies and this leads to the poor simulations of extratropical teleconnections over North America. In the NMME models, with active air–sea interaction, the negative WP precipitation anomalies show better agreement across the models and with observations. However, the downstream wave train pattern and the resulting extratropical responses over North America exhibit large disagreement across the models and are consistently weaker than in observations. Furthermore, in these climate models, an anomalous anticyclone does not robustly translate into a warm anomaly over the Midwest, in disagreement with observations. This work suggests that, during the El Niño to La Niña transitioning summer, active air–sea interaction is important in simulating tropical precipitation over the WP. Nevertheless, skillful representations of the Rossby wave propagation and land–atmosphere processes in climate models are also essential for skillful simulations of extratropical responses over North America.
Supplementary Figures and tables Legends from Rapid functional and evolutionary changes follow gene duplication in yeast
Creators: name: Naseeb, Samina
name: Ames, Ryan M.
name: Delneri, Daniela
name: Lovell, Simon C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Duplication of genes or genomes provides the raw material for evolutionary innovation. After duplication a gene may be lost, recombine with another gene, have its function modified, or be retained in an unaltered state. The fate of duplication is usually studied by comparing extant genomes and reconstructing the most likely ancestral states. Valuable as this approach is, it may miss the most rapid evolutionary events. Here, we engineered strains of Saccharomyces cerevisiae carrying tandem and non-tandem duplications of the singleton gene IFA38 to monitor (i) the fate of the duplicates in different conditions, including timescale and asymmetry of gene loss and (ii) the changes in fitness and transcriptome of the strains immediately after duplication and after experimental evolution. We found that the duplication brings widespread transcriptional changes but a fitness advantage is only present in fermentable media. In respiratory conditions, the yeast strains consistently lose the non-tandem IFA38 gene copy in a surprisingly short time, within only few generations. This gene loss appears to be asymmetric and dependent on genome location since the original IFA38 copy and the tandem duplicate are retained. Overall, this work shows for the first time that gene loss can be extremely rapid and context dependent.
Additional file 1 of Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies
Creators: name: Liu, Ke
name: Chen, Weiwei
name: Zhou, Yi
name: Xu, Liuhong
name: Sun, Xiaohui
name: Mao, Yingying
name: Ye, Ding
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Supplementary Material 1
At the Harriman Institute: The Foreign Policy of Azerbaijan: Affecting Factors and Priorities
Creators: Udensiva-Brenner, Masha
Publisher: name: Columbia University
Year: 2010
Subjects: International relations

description: At a forum cosponsored by Columbia University's Harriman Institute, and the Center for Energy, Marine Transportation and Public Policy, Elmar Mammadyarov stressed that the resolution of the Armenian-Azeri conflict was his first, second, and third priority as Foreign Minister of Azerbaijan, “You can imagine that when you have almost 20 percent of your territory under occupation, and when you have almost a million of your people internally displaced by refuges from Armenia, it will have a very serious impact on determining foreign policy priorities,” Mr. Mammadyarov remarked.
At the Harriman Institute: Overcoming Warlords and State Failure: Lessons from Post-Soviet Georgia
Creators: Udensiva-Brenner, Masha
Publisher: name: Columbia University
Year: 2010
Subjects: subject: Warlordism
subject: Political science
subject: FOS: Political science

description: On Wednesday, November 11, 2009, Kimberly Marten, Professor of Political Science at Barnard College, Columbia University, spoke at the Harriman Institute about two Georgian warlords—Aslan Abashidze and Emzar Kvitsiani. Marten discussed their influence in Georgia, and the divergent approaches towards warlordism taken by the administrations of Georgian leaders Eduard Shevardnadze (1992-03) and Mikheil Saakashvili (2003-present).
At the Harriman Institute: An Overview of U.S.-Russia Relations
Creators: Udensiva-Brenner, Masha
Publisher: name: Columbia University
Year: 2010
Subjects: International relations
Diplomatic relations

description: “Let me say that it's nice to be home,” pronounced Mr. Ian C. Kelly, Department Spokesman and former Director of the Office of Russian Affairs at the U.S. Department of State, and an alumnus of Columbia University. “For me, the Harriman Institute was kind of a home away from home,” he expressed, recalling how he had written his Ph.D. dissertation in the basement of the library, coming up to the Institute whenever he wanted “a sense of community, and a place to unwind and have stimulating discussions.” Kelly discussed the relationship between Russia and the United States at a Harriman-sponsored lecture on September 29, 2009. “I would like to break my remarks into three sections,” Kelly began. “Why it is that the Obama administration thinks that Russia matters; in what areas do we have good cooperation with Russia; and on what areas don't we agree?” Kelly stressed Russia's position as the largest country in the world, which, “sits on top of three regions vital to our interests: Europe, the Middle East, and Northeast Asia. Areas from which the Obama administration faces some of its biggest challenges,” he remarked.
Table S1 from Rapid functional and evolutionary changes follow gene duplication in yeast
Creators: name: Naseeb, Samina
name: Ames, Ryan M.
name: Delneri, Daniela
name: Lovell, Simon C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Duplication of genes or genomes provides the raw material for evolutionary innovation. After duplication a gene may be lost, recombine with another gene, have its function modified, or be retained in an unaltered state. The fate of duplication is usually studied by comparing extant genomes and reconstructing the most likely ancestral states. Valuable as this approach is, it may miss the most rapid evolutionary events. Here, we engineered strains of Saccharomyces cerevisiae carrying tandem and non-tandem duplications of the singleton gene IFA38 to monitor (i) the fate of the duplicates in different conditions, including timescale and asymmetry of gene loss and (ii) the changes in fitness and transcriptome of the strains immediately after duplication and after experimental evolution. We found that the duplication brings widespread transcriptional changes but a fitness advantage is only present in fermentable media. In respiratory conditions, the yeast strains consistently lose the non-tandem IFA38 gene copy in a surprisingly short time, within only few generations. This gene loss appears to be asymmetric and dependent on genome location since the original IFA38 copy and the tandem duplicate are retained. Overall, this work shows for the first time that gene loss can be extremely rapid and context dependent.
A semiparametric type II Tobit model for time-to-event data with application to a merger and acquisition study
Creators: name: Li, Yilin
name: Zheng, Ming
name: Yu, Wen
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Medicine
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy

description: Merger and acquisition is an important corporate strategy. We collect recent merger and acquisition data for companies on the China A-share stock market to explore the relationship between corporate ownership structure and speed of merger success. When studying merger success, selection bias occurs if only completed mergers are analyzed. There is also a censoring problem when duration time is used to measure the speed. In this article, for time-to-event outcomes, we propose a semiparametric version of the type II Tobit model that can simultaneously handle selection bias and right censoring. The proposed model can also easily incorporate time-dependent covariates. A nonparametric maximum likelihood estimator is proposed. The resulting estimators are shown to be consistent, asymptotically normal, and semiparametrically efficient. Some Monte Carlo studies are carried out to assess the finite-sample performance of the proposed approach. Using the proposed model, we find that higher power balance of a company is associated with faster merger success.
title: ITO-Free Transparent Organic Solar Cell with Distributed Bragg Reflector for Solar Harvesting Windows
Creators: name: Peng, Yuelin
name: Zhang, Lushuai
name: Cheng, Nongyi
name: Andrew, Trisha L.
Publisher: name: University of Massachusetts Amherst
Year: 2017
Subjects: subject: transparent electrode
subject: organic photovoltaic
subject: distributed Bragg reflector

description: We demonstrated an indium tin oxide (ITO)-free, highly transparent organic solar cell with the potential to be integrated into window panes for energy harvesting purposes. A transparent, conductive ZnO/Ag/ZnO multilayer electrode and a Ag:Ca thin film electrode were used in this transparent device as the bottom and top electrode, respectively. To further improve the transmittance of the solar cell, the thickness of the top ZnO layer was investigated both experimentally and with simulations. An average visible transmittance of >60% was reached, with a maximum transmittance of 73% at 556 nm. Both top and bottom illumination of the solar cell generated comparable power conversion efficiencies, which indicates the wide application of this solar cell structure. In addition, we fabricated distributed Bragg reflector mirrors with sputtered SiO2 and TiO2, which efficiently increased the power conversion efficiency over 20% for the solar cells on glass and poly(ethylene terephthalate) (PET) substrates.
Atlantic Multidecadal Variability as a modulator of the precipitation variability in the continental US
Creators: Lee, Dong Eun
Ting, Mingfang
Vigaud, Nicolas
Kushnir, Yochanan
Barnston, Anthony G.
Publisher: name: Columbia University
Year: 2018
Subjects: Ocean-atmosphere interaction
Precipitation (Meteorology)
Climatic changes--Mathematical models
Climatology

description: Two independent atmospheric general circulation models reveal that the positive (negative) phase of Atlantic multidecadal variability (AMV) can reduce (amplify) the variance of the shorter time-scale (e.g., ENSO related) precipitation fluctuations in the United States, especially in the Southwest, as well as decrease (increase) the long-term seasonal mean precipitation for the cold season. The variance is modulated because of changes in 1) dry day frequency and 2) maximum daily rainfall intensity. With positive AMV forcing, the upper-level warming originating from the increased precipitation over the tropical Atlantic Ocean changes the mean vertical thermal structure over the United States continent to a profile less favorable for rain-inducing upward motions. In addition, a northerly low-level dry advection associated with the local overturning leaves less available column moisture for condensation and precipitation. The opposite conditions occur during cold AMV periods.