cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Table S1 from Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats.
Creators: name: Rafie, Karim
name: Olawale Raimi
name: Ferenbach, Andrew T.
name: Borodkin, Vladimir S.
name: Vaibhav Kapuria
name: Aalten, Daan M. F. Van
Publisher: name: The Royal Society
Year: 2017
Subjects: Biochemistry
Structural Biology

description: O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-translational modification found on hundreds of nucleocytoplasmic proteins in metazoa. Although a single enzyme, O-GlcNAc transferase (OGT), generates the entire cytosolic O-GlcNAc proteome, it is not understood how it recognizes its protein substrates, targeting only a fraction of serines/threonines in the metazoan proteome for glycosylation. We describe a trapped complex of human OGT with the C-terminal domain of TAB1, a key innate immunity-signalling O-GlcNAc protein, revealing extensive interactions with the tetratricopeptide repeats of OGT. Confirmed by mutagenesis, this interaction suggests that glycosylation substrate specificity is achieved by recognition of a degenerate sequon in the active site combined with an extended conformation C-terminal of the O-GlcNAc target site.
Quadratic algebras as commutants of algebraic Hamiltonians in the enveloping algebra of Schrödinger algebras
Creators: name: Campoamor-Stursberg, Rutwig
name: Marquette, Ian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We discuss a procedure to determine finite sets $\mathcal{M}$ within the commutant of an algebraic Hamiltonian in the enveloping algebra of a Lie algebra $\mathfrak{g}$ such that their generators define a quadratic algebra. Although independent from any realization of Lie algebras by differential operators, the method is partially based on an analytical approach, and uses the coadjoint representation of the Lie algebra $\mathfrak{g}$. The procedure, valid for non-semisimple algebras, is tested for the centrally extended Schrödinger algebras $\widehat{S}(n)$ for various different choices of algebraic Hamiltonian. For the so-called extended Cartan solvable case, it is shown how the existence of minimal quadratic algebras can be inferred without explicitly manipulating the enveloping algebra.
[PDF/Kindle] Money Shackles: The Breakout Guide to Alternative Investing by Dutch Mendenhall
Creators: name: Chalk
Publisher: name: Zenodo
Year: 2024

description: Money Shackles: The Breakout Guide to Alternative Investing by Dutch Mendenhall

 

 

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Money Shackles: The Breakout Guide to Alternative Investing

Dutch Mendenhall

Page: 181

Format: pdf, ePub, mobi, fb2

ISBN: 9781954759282

Publisher: Michaels Press

 

Textbooks downloads free Money Shackles: The Breakout Guide to Alternative Investing by Dutch Mendenhall in English

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Table S1 from Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats
Creators: name: Rafie, Karim
name: Olawale Raimi
name: Ferenbach, Andrew T.
name: Borodkin, Vladimir S.
name: Vaibhav Kapuria
name: Aalten, Daan M. F. Van
Publisher: name: The Royal Society
Year: 2017
Subjects: Biochemistry
Structural Biology

description: O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-translational modification found on hundreds of nucleocytoplasmic proteins in metazoa. Although a single enzyme, O-GlcNAc transferase (OGT), generates the entire cytosolic O-GlcNAc proteome, it is not understood how it recognizes its protein substrates, targeting only a fraction of serines/threonines in the metazoan proteome for glycosylation. We describe a trapped complex of human OGT with the C-terminal domain of TAB1, a key innate immunity signalling O-GlcNAc protein, revealing extensive interactions with the tetratricopeptide repeats of OGT. Confirmed by mutagenesis, this interaction suggests that glycosylation substrate specificity is achieved by recognition of a degenerate sequon in the active site combined with an extended conformation C-terminal of the O-GlcNAc target site.
Charting the $q$-Askey scheme
Creators: name: Koornwinder, Tom H.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33D45

description: Following Verde-Star, Linear Algebra Appl. 627 (2021), we label families of orthogonal polynomials in the $q$-Askey scheme together with their $q$-hypergeometric representations by three sequences $x_k, h_k, g_k$ of Laurent polynomials in $q^k$, two of degree 1 and one of degree 2, satisfying certain constraints. This gives rise to a precise classification and parametrization of these families together with their limit transitions. This is displayed in a graphical scheme. We also describe the four-manifold structure underlying the scheme.
description: 17 pages, one figure; in v2 minor corrections, one remark and three references added; to appear in "Proceedings of the Conference on Hypergeometry, Integrability and Lie Theory", Contemporary Mathematics
TOXOSOURCES - Toxoplasma gondii sources quantified
Creators: name: Jokelainen, Pikka
name: Opsteegh, Marieke
name: Lalle, Marco
name: Spano, Furio
name: Schares, Gereon
name: Pires, Sara M.
name: Mayer-Scholl, Anne
name: Seeber, Frank
name: Cacciò, Simone M.
name: van der Giessen, Joke
name: TOXOSOURCES Consortium
Publisher: name: Zenodo
Year: 2020
Subjects: Toxoplasma gondii
TOXOSOURCES

description: TOXOSOURCES - Toxoplasma gondii sources quantified. Poster presented at 2nd Annual Scientific Meeting of the One Health EJP.
Download Pdf Icarus by K. Ancrum
Creators: name: Bray
Publisher: name: Zenodo
Year: 2024

description: Icarus by K. Ancrum

 

 

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Icarus

K. Ancrum

Page: 400

Format: pdf, ePub, mobi, fb2

ISBN: 9780063285781

Publisher: HarperCollins

 

Ebook online download Icarus by K. Ancrum (English literature) 9780063285781

Overview

Perfect for fans of Adam Silvera and Aristotle and Dante Discover the Secrets of the Universe, this suspenseful queer YA romance from critically acclaimed author K. Ancrum reimagines the tale of Icarus as a star-crossed love story between a young art thief and the son of the man he’s been stealing from—think Portrait of a Thief for YA readers. Icarus Gallagher is a thief. He steals priceless art and replaces it with his father’s impeccable forgeries. For years, one man—the wealthy Mr. Black—has been their target in revenge for his role in the death of Icarus’s mother. To keep their secret, Icarus adheres to his own strict rules to keep people, and feelings, at bay: Don’t let anyone close. Don’t let anyone touch you. And, above all, don’t get caught. Until one night, he does. Not by Mr. Black but by his mysterious son, Helios, now living under house arrest in the Black mansion. Instead of turning Icarus in, Helios bargains for something even more dangerous—a friendship that breaks every single one of Icarus’s rules. As reluctance and distrust become closeness and something more, they uncover the gilded cage that has trapped both their families for years. One Icarus is determined to escape. But his father’s thirst for revenge shows no sign of fading, and soon it may force Icarus to choose: the escape he’s dreamed of, or the boy he’s come to love. Reaching for both could be his greatest triumph—or it could be his downfall.
Asymmetric Gold(I)- and Brønsted Acid-Catalysed Chemistry of Alcohols as Novel Strategies for Complex Molecule Synthesis
Creators: name: CARLI, LORENZO
Publisher: name: Monash University
Year: 2023
Subjects: Catalysis and mechanisms of reactions
Organic chemical synthesis
Organic green chemistry

description: Transition metal and organic catalysts were employed in the development of new reactions for the selective assembly of complex chiral molecules from common starting materials.
Stirring by Staring: Measurement Induced Chirality
Creators: name: Wampler, Matthew
name: Khor, Brian J. J.
name: Refael, Gil
name: Klich, Israel
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In quantum mechanics, the observer necessarily plays an active role in the dynamics of the system, making it difficult to probe a system without disturbing it. Here, we leverage this apparent difficulty as a tool for driving an initially trivial system into a chiral phase. In particular, we show that by utilizing a pattern of repeated occupation measurements we can produce chiral edge transport of fermions hopping on a Lieb lattice. The procedure is similar in spirit to the use of periodic driving to induce chiral edge transport in Floquet topological insulators, while also exhibiting novel phenomena due to the non-unitary nature of the quantum measurements. We study in detail the dependence of the procedure on measurement frequency, showing that in the Zeno limit the system can be described by a classical stochastic dynamics, yielding protected transport. As the frequency of measurements is reduced, the charge flow is reduced and vanishes when no measurements are done.
Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice.
Creators: name: Reynolds, John B.
name: Surles, L. Kester
name: Maeda, Nobuyo
name: Jones, Robert G.
name: Quarfordt, Steven H.
name: Zhang, Sunny H.
name: Avdievich, Elena
name: Reddick, Robert L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Dietary administration of probucol (0.5%, wt/wt) efficiently reduced total plasma cholesterol levels in apolipoprotein E-deficient mice (apoE-/-) by 40%, with decreases in high density lipoprotein (HDL) and apoAI by 70 and 50%, respectively. Paradoxically, however, aortic atherosclerotic plaques in the probucol-treated apoE-/- mice formed more rapidly than in the untreated apoE-/- mice, and the lesions were two to four times larger and more mature regardless of sex, age, and genetic background (P < 10(-)6). Histologically, lesions in probucol-treated mice contained increased fibrous materials and cells other than foam cells, and were commonly associated with focal inflammation and aneurysmal dilatation. Probucol treatment also accelerated lesion development in apoE+/- mice fed an atherogenic diet, indicating that the adverse effect is not dependent on the complete absence of apoE. Furthermore, mice lacking apoE and apoAI have plasma lipoprotein profiles very similar to the probucol-treated apoE-/- mice, but do not have accelerated plaque development. Thus, the enhanced atherosclerosis in the probucol-treated animals is unlikely to be caused by the reduction of HDL and apoAI levels. Our data indicate that a reduction in plasma cholesterol caused by probucol does not necessarily lead to an antiatherogenic effect.
Electronic Supplementary Material from Exposure to the leaf litter microbiome of healthy adults protects seedlings from pathogen damage.
Creators: name: Christian, Natalie
name: Herre, Edward Allen
name: Mejia, Luis C.
name: Clay, Keith
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology

description: Contains supplementary figures and tables
On the renormalization of quasi parton distribution
Creators: name: Ji, Xiangdong
name: Zhang, Jian-Hui
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent developments showed that light-cone parton distributions can be studied by investigating the large momentum limit of the hadronic matrix elements of spacelike correlators, which are known as quasi parton distributions. Like a light-cone parton distribution, a quasi parton distribution also contains ultraviolet divergences and therefore needs renormalization. The renormalization of non-local operators in general is not well understood. However, in the case of quasi quark distribution, the bilinear quark operator with a straight-line gauge link appears to be multiplicatively renormalizable by the quark wave function renormalization in the axial gauge. We first show that the renormalization of the self energy correction to the quasi quark distribution is equivalent to that of the heavy-light quark vector current in heavy quark effective theory at one-loop order. Assuming this equivalence at two-loop order, we then show that the multiplicative renormalizability of the quasi quark distribution is true at two-loop order.
description: 14 pages, 4 figures
Natural Supersymmetry and Unification in Five Dimensions
Creators: name: Abdalgabar, Ammar
name: Cornell, Alan S.
name: Deandrea, Aldo
name: McGarrie, Moritz
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore unification and natural supersymmetry in a five dimensional extension of the standard model in which the extra dimension may be large, of the order of 1-10 TeV. Power law running generates a TeV scale A_ term allowing for the observed 125 GeV Higgs and allowing for stop masses below 2 TeV, compatible with a natural SUSY spectrum. We supply the full one-loop RGEs for various models and use metastability to give a prediction that the gluino mass should be lighter than 3.5 TeV for A_t <= 2.5 TeV, for such a compactification scale, with brane localised 3rd generation matter. We discuss why models in which the 1st and 2nd generation of matter fields are located in the bulk are likely to be ruled out. We also look at electroweak symmetry breaking in these models.
description: 34 pages, 12 figures
Online Read Ebook La marche de Radetzky
Creators: name: Banning
Publisher: name: Zenodo
Year: 2024

description: La marche de Radetzky pan Joseph Roth

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La marche de Radetzky

Joseph Roth

Nb. de pages: 352

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782021114263

Editeur: Seuil

Date de parution: 2013

 

 

 

Téléchargez des livres epub pour ipad La marche de Radetzky

 

Overview

Plus qu’un roman historique, La Marche de Radetsky est avant tout celui d’une famille. Chroniqueur du quotidien par excellence, Roth s'attache à illustrer l’inéluctable désagrégation de l’Autriche-Hongrie à travers la destinée de trois générations de von Trotta, trois hommes distants et pourtant attachants. Le premier, héros de la bataille de Solferino où il sauva la vie du jeune empereur François-Joseph (ce qui lui valut l’anoblissement de sa lignée d’humble origine slovène et qui lia à jamais le destin de sa famille à celui de la Maison Habsbourg), son fils devenu préfet de l’Empire, et son petit-fils, officier de l'armée impériale qui vivra les derniers soubresauts du règne et les premiers jours de la Première Guerre mondiale. La lente décomposition de la société autrichienne et de l’ordre de cet empire cosmopolite qu’évoque avec mélancolie Joseph Roth, s’accompagne de la disparition d’un univers pluriculturel étonnant où mondes slave et germanique, judaïsme et catholicisme coexistaient. Ainsi, le leitmotiv musical du roman, la Marche de Radetsky, marche militaire aux accents joyeux composée par Johann Strauss père en l’honneur du maréchal Radetsky von Radetz entré triomphalement dans Milan en mars 1848 après l’écrasement de l’insurrection italienne en Lombardie-Vénétie, devient sous la plume de l’auteur autrichien une marche funèbre qui scande l’inexorable déclin de la monarchie austro-hongroise.
Electronic Supplementary Material from Exposure to the leaf litter microbiome of healthy adults protects seedlings from pathogen damage
Creators: name: Christian, Natalie
name: Herre, Edward Allen
name: Mejia, Luis C.
name: Clay, Keith
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology

description: Contains supplementary figures and tables
PDF [Download] Teaching the Mindful Self-Compassion Program: A Guide for Professionals by Christopher Germer PhD, Kristin Neff PhD
Creators: name: Byrd
Publisher: name: Zenodo
Year: 2024

description: Teaching the Mindful Self-Compassion Program: A Guide for Professionals by Christopher Germer PhD, Kristin Neff PhD

 

 

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Teaching the Mindful Self-Compassion Program: A Guide for Professionals

Christopher Germer PhD, Kristin Neff PhD

Page: 452

Format: pdf, ePub, mobi, fb2

ISBN: 9781462538898

Publisher: Guilford Publications, Inc.

 

Download free e books for blackberry Teaching the Mindful Self-Compassion Program: A Guide for Professionals by Christopher Germer PhD, Kristin Neff PhD

Synopsis PDF Teaching the Mindful Self-Compassion Program: A Guide for Professionals by Christopher Germer PhD, Kristin Neff PhD EPUB Download zip file. Facebook share full length digital edition EPUB Teaching the Mindful Self-Compassion Program: A Guide for Professionals By Christopher Germer PhD, Kristin Neff PhD PDF Download. Novels - upcoming Teaching the Mindful Self-Compassion Program: A Guide for Professionals EPUB PDF Download Read Christopher Germer PhD, Kristin Neff PhD. PDF Teaching the Mindful Self-Compassion Program: A Guide for Professionals by Christopher Germer PhD, Kristin Neff PhD EPUB Download Share link here and get free ebooks to read online. Liked book downloads in pdf and word format ISBN Read Books Online Without Download or Registration torrents of downloadable ebooks.

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Recent Advances in Bianisotropic Boundary Conditions: Theory, Capabilities, Realizations, and Applications
Creators: name: Budhu, Jordan
name: Grbic, Anthony
Publisher: name: arXiv
Year: 2021
Subjects: subject: Applied Physics (physics.app-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In recent years, new functionality and unprecedented wavefront control has been enabled by the introduction of bianisotropic metasurfaces. A bianisotropic metasurface is characterized by an electric response, a magnetic response, and an electromagnetic/magnetoelectric response. In general, these metasur-faces consists of an array of metallic or dielectric particles located within a subwavelength thick host medium, and are approximated and modelled as infinitely-thin, idealized sheet boundaries defined along a surface. An appropriate sheet boundary condition which effectively models the tangential field discontinuity due to the array of magnetoelectric inclusions is the Generalized Sheet Transition Condition or GSTC. Several forms of the GSTC appear in literature. Here, we present each interpretation and show how they are related. Synthesis approaches unique to each form are overviewed. By utilizing the GSTC in metasurface design, new possibilities emerge which are not possible with conventional design techniques incorporating only electric or only magnetic responses. Since the metasurfaces are designed using bianisotropic boundary conditions, they must be realized using particles which contain magnetoelectric responses. This review article discusses the design of metasurfaces using the GSTC, and the bianisotropic particles used to realize GSTCs. Further, it discusses new and recent applications that have emerged due to bianisotropy, and future prospects in metasurface design using bianisotropic boundary conditions. The intent is to provide a comprehensive overview of metasurface design involving bianisotropy and for this review article to serve as a starting point for engineers and scientist that wish to introduce bianisotropy into metasurface design.
description: Submitted to Nanophotonics as an invited review article
EL PEQUEÑO LIBRO DE VALENTINO leer pdf
Creators: name: Haynes
Publisher: name: Zenodo
Year: 2024

description: EL PEQUEÑO LIBRO DE VALENTINO de KAREN HOMER

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EL PEQUEÑO LIBRO DE VALENTINO

KAREN HOMER

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788419785244

Editorial: BLUME

Año de edición: 2023

 

 

 

 

 

E-libros deutsh descarga gratuita EL PEQUEÑO LIBRO DE VALENTINO de KAREN HOMER 9788419785244

 

Overview
Some aspects of the five-dimensional Lovelock black hole spacetime: strong homotopy retract, perihelion precession and quasistationary levels
Creators: name: Abu-Saleem, M.
name: Vieira, H. S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: Algebraic Topology (math.AT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this work we explore some mathematical physics aspects of the spherically symmetric Lovelock black hole in high dimensions. Intended for this aim, we thoroughly consider the metric corresponding to the five-dimensional Lovelock black hole spacetime. We construct the strong retractions by the geodesic equations on the background under consideration. As a result, from the topological point of view, we construct the theory of strong homotopy retract, which will allow us, in principle, to better understand some of its suitable applications on astrophysics and cosmology, in particular, in the analysis of the spacetime singularities. We find the solutions of the equation of motion for both radial and angular coordinates, and then we describe the outer ("exterior") and lower ("interior") apparent horizons. Indeed, the outer apparent horizon is the last surface from which the light waves could still escape from the black hole. Thus, it is meaningful to analyze some physical phenomena related to quantum particles propagating outside the exterior apparent horizon, in particular, we discuss the quasistationary levels of scalar fields and their radial wave functions, which are given in terms of the general Heun functions. We also calculate the perihelion precession in this background.
description: 14 pages, 4 figures
[PDF] The Surgeon by Leslie Wolfe
Creators: name: Bush
Publisher: name: Zenodo
Year: 2024

description: The Surgeon by Leslie Wolfe

 

 

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The Surgeon

Leslie Wolfe

Page: 288

Format: pdf, ePub, mobi, fb2

ISBN: 9781538767375

Publisher: Grand Central Publishing

 

Free download ebooks for pda The Surgeon 9781538767375

Overview

A totally gripping psychological thriller that will have you racing through the pages, gasping for breath until the final jaw-dropping twist—perfect for fans of The Housemaid, Verity, and The Girl on the Train. Trusted surgeon. Loving wife. Murderer? Before my world came crashing down, I had it all. The successful career I dreamed of. The beautiful red-brick home where I could relax in front of the fire. The handsome, devoted husband whose blue eyes and charming smile always made me feel safe. As I call time of death, my voice is steady. My colleagues stand hushed around me, their eyes on me, confused, concerned. I have never lost a patient until today. My hands tremble inside their gloves. I slide down the cold tiled walls, my heart racing in my chest. I have never hated a patient until today. But what choice did I have, once I recognized him? And what will I do to protect myself, if someone learns the truth?
[Pdf/ePub] Kaizen  - La méthode japonaise du petit pas pour changer toutes ses habitudes by Sarah Harvey download ebook
Creators: name: Trafton
Publisher: name: Zenodo
Year: 2024

description: Kaizen - La méthode japonaise du petit pas pour changer toutes ses habitudes pan Sarah Harvey

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Kaizen - La méthode japonaise du petit pas pour changer toutes ses habitudes

Sarah Harvey

Nb. de pages: 253

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782755644722

Editeur: Hugo et Compagnie

Date de parution: 2020

 

 

 

Télécharger des ebooks google Kaizen - La méthode japonaise du petit pas pour changer toutes ses habitudes par Sarah Harvey 9782755644722 (Litterature Francaise)

 

Overview

Le Kaizen est la méthode douce japonaise pour changer ses habitudes. C'est la mise en oeuvre continue de petits changements qui conduit à des améliorations significatives sur le long terme ; en japonais, le mot kaizen veut, dire "amélioration continue" et est déjà éprouvé depuis longtemps par l'industrie japonaise. Cette conduite du changement peut se résumer en une phrase : "Mieux qu'hier, moins bien que demain". Le Kaizen présente l'avantage de s'appliquer dans tous les domaines de la vie quotidienne, travail, rangement de la maison, bien-être ou finances personnelles... Il suffit d'avancer d'un petit pas, jour après jour. Les efforts paraissent minimes, même quand l'objectif est important. Alors, oubliez tous les ouvrages qui vous promettent une vie meilleure. Dans la plupart des cas, ces solutions sont trop radicales : on finit par se faire rattraper par les réalités de la vie et par abandonner l'espoir de conserver de bonnes habitudes. Adoptez le Kaizen !
{pdf download} Knight Owl by Christopher Denise
Creators: name: Sanford
Publisher: name: Zenodo
Year: 2024

description: Knight Owl by Christopher Denise

 

 

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Knight Owl

Christopher Denise

Page: 48

Format: pdf, ePub, mobi, fb2

ISBN: 9780316310628

Publisher: Little, Brown Books for Young Readers

 

Free books to download for android phones Knight Owl

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Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl– cotransporter
Creators: name: Athirakul, Krairek
name: Pace, Amy J.
name: O'Brien, Deborah A.
name: Koller, Beverly H.
name: Coffman, Thomas M.
name: Lee, Eddie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The Na+-K+-2Cl– cotransporter (NKCC1) carries 1 molecule of Na+ and K+ along with 2 molecules of Cl– across the cell membrane. It is expressed in a broad spectrum of tissues and has been implicated in cell volume regulation and in ion transport by secretory epithelial tissue. However, the specific contribution of NKCC1 to the physiology of the various organ systems is largely undefined. We have generated mouse lines carrying either of 2 mutant alleles of the Slc12a2 gene, which encodes this cotransporter: a null allele and a mutation that results in deletion of 72 amino acids of the cytoplasmic domain. Both NKCC1-deficient mouse lines show behavioral abnormalities characteristic of mice with inner ear defects. Male NKCC1-deficient mice are infertile because of defective spermatogenesis, as shown by the absence of spermatozoa in histological sections of their epididymides and the small number of spermatids in their testes. Consistent with this observation, we show that Slc12a2 is expressed in Sertoli cells, pachytene spermatocytes, and round spermatids isolated from wild-type animals. Our results indicate a critical role for NKCC1-mediated ion transport in spermatogenesis and suggest that the cytoplasmic domain of NKCC1 is essential in the normal functioning of this protein.
Accretion Flow Properties of MAXI J1910-057/Swift J1910.2-0546 During Its 2012-13 Outburst
Creators: name: Nath, Sujoy Kumar
name: Debnath, Dipak
name: Chatterjee, Kaushik
name: Jana, Arghajit
name: Chatterjee, Debjit
name: Bhowmick, Riya
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Galactic black hole candidate MAXI J1910-057/Swift J1910.2-0546 was simultaneously discovered by MAXI/GSC and Swift/BAT satellites during its first outburst in 2012. We study the detailed spectral and temporal properties of the source in a broad energy range using archival data from Swift/XRT, MAXI/GSC and Swift/BAT satellites/instruments. Low frequency quasi periodic oscillations are observed during the outburst. The combined 1-50 keV spectra are analyzed using the transonic flow solution based Two Component Advective Flow (TCAF) model. Based on the variations of soft and hard X-ray fluxes, their hardness ratios and the variations of the spectral model fitted parameters, we find that the source has evolved through six spectral states. We interpret this spectral state evolution to be a result of two connected outbursts where the leftover matter from a primary outburst is released from the pile-up radius due to a sudden rise of viscosity causing a reflare/secondary outburst. We show a possible configuration of the evolution of accretion flow during the outburst. From the spectral analysis with TCAF model, we estimate the mass of the black hole to be $9.97^{+3.51}_{-3.24}$ $M_\odot$ , and the source distance is estimated to be $3.4-9.6$~kpc from transition luminosity considerations.
description: 15 Pages, 8 Figures, 3 Tables (accepted for publication in Advances in Space Research)
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
Creators: name: Maeda, Nobuyo
name: Hossain, Gazi S.
name: Werstuck, Geoff H.
name: Sood, Sudesh K.
name: Austin, Richard C.
name: Krisans, Skaidrite K.
name: Malinow, M. Rene
name: Lentz, Steven R.
name: Dayal, Sanjana
name: Shi, Yuan Y.
name: Zhou, Ji
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Hepatic steatosis is common in patients having severe hyperhomocysteinemia due to deficiency for cystathionine β-synthase. However, the mechanism by which homocysteine promotes the development and progression of hepatic steatosis is unknown. We report here that homocysteine-induced endoplasmic reticulum (ER) stress activates both the unfolded protein response and the sterol regulatory element–binding proteins (SREBPs) in cultured human hepatocytes as well as vascular endothelial and aortic smooth muscle cells. Activation of the SREBPs is associated with increased expression of genes responsible for cholesterol/triglyceride biosynthesis and uptake and with intracellular accumulation of cholesterol. Homocysteine-induced gene expression was inhibited by overexpression of the ER chaperone, GRP78/BiP, thus demonstrating a direct role of ER stress in the activation of cholesterol/triglyceride biosynthesis. Consistent with these in vitro findings, cholesterol and triglycerides were significantly elevated in the livers, but not plasmas, of mice having diet-induced hyperhomocysteinemia. This effect was not due to impaired hepatic export of lipids because secretion of VLDL-triglyceride was increased in hyperhomocysteinemic mice. These findings suggest a mechanism by which homocysteine-induced ER stress causes dysregulation of the endogenous sterol response pathway, leading to increased hepatic biosynthesis and uptake of cholesterol and triglycerides. Furthermore, this mechanism likely explains the development and progression of hepatic steatosis and possibly atherosclerotic lesions observed in hyperhomocysteinemia.
[PDF/Kindle] Dictionnaire de SVT  - Sciences de la Vie et de la Terre by Michel Breuil
Creators: name: Le
Publisher: name: Zenodo
Year: 2024

description: Dictionnaire de SVT - Sciences de la Vie et de la Terre pan Michel Breuil

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Dictionnaire de SVT - Sciences de la Vie et de la Terre

Michel Breuil

Nb. de pages: 605

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782091520155

Editeur: Nathan

Date de parution: 2018

 

 

 

Meilleures ventes eBook Dictionnaire de SVT - Sciences de la Vie et de la Terre CHM 9782091520155 par Michel Breuil

 

Overview

Une référence incontournable avec plus de 5 000 définitions pour comprendre la biologie, l'écologie, le développement durable, la géologie et leurs enjeux dans le monde contemporain. Ce dictionnaire est accessible et pratique grâce à son système de renvois efficaces et ses schémas descriptifs et explicatifs. Un véritable outil d'apprentissage et de révisions : pour le Bac avec des explications sur les thèmes du lycée ; pour les études supérieures avec une annexe spéciale BCPST. En annexe, 4 lexiques spécifiques et inédits : méthodologie et pédagogie, systématique phylogénétique, terminologie des Alpes occidentales, classes prépa BCPST.
Green function for gradient perturbation of unimodal Lévy processes
Creators: name: Grzywny, Tomasz
name: Jakubowski, Tomasz
name: Żurek, Grzegorz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 47A55, 60J35, 60J50, 60J75, 47G20

description: We prove that the Green function of a generator of isotropic unimodal Lévy processes with the weak lower scaling order bigger than one and the Green function of its gradient perturbations are comparable for bounded smooth open sets if the drift function is from an appropriate Kato class.
description: 22 pages
A Multi-Objective Particle Swarm Optimization for Mixed-Model Assembly Line Balancing with Different Skilled Workers
Creators: name: Fattahi, Parviz
Publisher: name: figshare
Year: 2020
Subjects: subject: 10303 Optimisation
subject: FOS: Mathematics

description: A Multi-Objective Particle Swarm Optimization for Mixed-Model
Assembly Line Balancing with Different Skilled Workers
Length matters: keeping atomic wires in check
Creators: name: Cunningham, Brian
name: Todorov, Tchavdar N.
name: Dundas, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Dynamical effects of non-conservative forces in long, defect free atomic wires are investigated. Current flow through these wires is simulated and we find that during the initial transient, the kinetic energies of the ions are contained in a small number of phonon modes, closely clustered in frequency. These phonon modes correspond to the waterwheel modes determined from preliminary static calculations. The static calculations allow one to predict the appearance of non-conservative effects in advance of the more expensive real-time simulations. The ion kinetic energy redistributes across the band as non-conservative forces reach a steady state with electronic frictional forces. The typical ion kinetic energy is found to decrease with system length, increase with atomic mass, and its dependence on bias, mass and length is supported with a pen and paper model. This paper highlights the importance of non-conservative forces in current carrying devices and provides criteria for the design of stable atomic wires.
description: 6 pages, 5 figures, conference proceedings from 2014 MRS fall meeting
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
Creators: name: Senior, Robert M.
name: Shipley, J. Michael
name: Diaz, Luis A.
name: Liu, Zhi
name: Werb, Zena
name: Li, Ning
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Extracellular proteolysis by the plasminogen/plasmin (Plg/plasmin) system and MMPs is required for tissue injury in autoimmune and inflammatory diseases. We demonstrate that a Plg cascade synergizes with MMP-9/gelatinase B in vivo during dermal-epidermal separation in an experimental model of bullous pemphigoid (BP), an autoimmune disease. BP was induced in mice by antibodies to the hemidesmosomal antigen BP180. Mice deficient in MMP-9 were resistant to experimental BP, while mice deficient in Plg and both tissue Plg activator (tPA) and urokinase Plg activator (uPA) showed delayed and less intense blister formation induced by antibodies to BP180. Plg-deficient mice reconstituted locally with Plg or the active form of MMP-9 (actMMP-9), but not the proenzyme form of MMP-9 (proMMP-9), developed BP. In contrast, proMMP-9 or actMMP-9, but not Plg, reconstituted susceptibility of MMP-9–deficient mice to the skin disease. In addition, MMP-3–deficient mice injected with pathogenic IgG developed the same degree of BP and expressed levels of actMMP-9 in the skin similar to those of WT controls. Thus, the Plg/plasmin system is epistatic to MMP-9 activation and subsequent dermal-epidermal separation in BP.
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca2+ release channel
Creators: name: Smithies, Oliver
name: Yamaguchi, Naohiro
name: Xu, Le
name: Takahashi, Nobuyuki
name: Meissner, Gerhard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Studies with isolated membrane fractions have shown that calmodulin (CaM) inhibits the activity of cardiac muscle cell Ca2+ release channel ryanodine receptor 2 (RyR2). To determine the physiological importance of CaM regulation of RyR2, we generated a mouse with 3 amino acid substitutions (RyR2-W3587A/L3591D/F3603A) in exon 75 of the Ryr2 gene, which encodes the CaM-binding site of RyR2. Homozygous mutant mice showed an increased ratio of heart weight to body weight, greatly reduced fractional shortening of the left ventricle, and lethality at 9–16 days of age. Biochemical analysis of hearts of 7- and 10-day-old homozygous mutant mice indicated an impaired CaM inhibition of RyR2 at micromolar Ca2+ concentrations, reduction in RyR2 protein levels and sarcoplasmic reticulum Ca2+ sequestration, and upregulation of genes and/or proteins associated with class II histone deacetylase/myocyte enhancer factor-2 and calcineurin signaling pathways. Sustained Ca2+ transients, often displaying repeated periods of incomplete Ca2+ removal, were observed in homozygous cardiomyocytes. Taken together, the data indicate that impaired CaM inhibition of RyR2, associated with defective sarcoplasmic reticulum Ca2+ release and altered gene expression, leads to cardiac hypertrophy and early death.
Modelling Time-Varying First and Second-Order Structure of Time Series via Wavelets and Differencing
Creators: name: McGonigle, Euan T.
name: Killick, Rebecca
name: Nunes, Matthew A.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Most time series observed in practice exhibit time-varying trend (first-order) and autocovariance (second-order) behaviour. Differencing is a commonly-used technique to remove the trend in such series, in order to estimate the time-varying second-order structure (of the differenced series). However, often we require inference on the second-order behaviour of the original series, for example, when performing trend estimation. In this article, we propose a method, using differencing, to jointly estimate the time-varying trend and second-order structure of a nonstationary time series, within the locally stationary wavelet modelling framework. We develop a wavelet-based estimator of the second-order structure of the original time series based on the differenced estimate, and show how this can be incorporated into the estimation of the trend of the time series. We perform a simulation study to investigate the performance of the methodology, and demonstrate the utility of the method by analysing data examples from environmental and biomedical science.
A matrix product algorithm for stochastic dynamics on networks, applied to non-equilibrium Glauber dynamics
Creators: name: Barthel, Thomas
name: De Bacco, Caterina
name: Franz, Silvio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: We introduce and apply a novel efficient method for the precise simulation of stochastic dynamical processes on locally tree-like graphs. Networks with cycles are treated in the framework of the cavity method. Such models correspond, for example, to spin-glass systems, Boolean networks, neural networks, or other technological, biological, and social networks. Building upon ideas from quantum many-body theory, the new approach is based on a matrix product approximation of the so-called edge messages -- conditional probabilities of vertex variable trajectories. Computation costs and accuracy can be tuned by controlling the matrix dimensions of the matrix product edge messages (MPEM) in truncations. In contrast to Monte Carlo simulations, the algorithm has a better error scaling and works for both, single instances as well as the thermodynamic limit. We employ it to examine prototypical non-equilibrium Glauber dynamics in the kinetic Ising model. Because of the absence of cancellation effects, observables with small expectation values can be evaluated accurately, allowing for the study of decay processes and temporal correlations.
description: 5 pages, 3 figures; minor improvements, published version
{pdf download} Ma vie sans gravité
Creators: name: Rubin
Publisher: name: Zenodo
Year: 2024

description: Ma vie sans gravité pan Thomas Pesquet

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Ma vie sans gravité

Thomas Pesquet

Nb. de pages: 560

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782379323089

Editeur: Libra Diffusio

Date de parution: 2024

 

 

 

Ebook télécharger deutsch free Ma vie sans gravité par Thomas Pesquet CHM iBook MOBI en francais

 

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[Kindle] UNA CORTE DE ROSAS Y ESPINAS. EDICIÓN ESPECIAL descargar gratis
Creators: name: Arnold
Publisher: name: Zenodo
Year: 2024

description: UNA CORTE DE ROSAS Y ESPINAS. EDICIÓN ESPECIAL de SARAH J. MAAS

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UNA CORTE DE ROSAS Y ESPINAS. EDICIÓN ESPECIAL

SARAH J. MAAS

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408285298

Editorial: PLANETA

Año de edición: 2024

 

 

 

 

 

Ebooks descargables para encender UNA CORTE DE ROSAS Y ESPINAS. EDICIÓN ESPECIAL in Spanish FB2 RTF 9788408285298

 

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¡Llévate el éxito de ventas de Sarah J. Maas en una cuidadísima edición especial! Un cuento de hadas nunca había sido tan sexy. ¡Déjate seducir por la saga del momento! (Libro 1) Cuando la cazadora Feyre mata a un lobo en el bosque, una criatura bestial irrumpe en su casa para exigir una compensación. Así, es trasladada a una tierra mágica y engañosa de la que solo había oído hablar en las leyendas, donde Feyre descubre que su captor no es un animal sino Tamlin: una divinidad inmortal y letal que alguna vez reinó en su mundo. Mientras Feyre vive en su castillo, lo que siente por Tamlin muta de una hostilidad helada a una pasión ardiente y feroz, a pesar de todas las mentiras y advertencias a las que queda expuesta en ese mundo fantástico, bello y peligroso. Además, una vil sombra ancestral crece sobre la tierra de las hadas día a día, y Feyre debe encontrar la forma de detenerla... o condenar a Tamlin –y a su mundo– para siempre.
PAR-1 contributes to the innate immune response during viral infection
Creators: name: Lee, Rebecca D.
name: Baunacke, Martin
name: Beck, Melinda A.
name: Sheridan, Patricia A.
name: Owens III, A. Phillip
name: Pawlinski, Rafal
name: Williams, Julie C.
name: Luyendyk, James P.
name: Mackman, Nigel
name: Kirchhofer, Daniel
name: Esserman, Denise A.
name: Rauch, Ursula
name: Blaxall, Burns C.
name: Antoniak, Silvio
name: Malz, Ronny
name: Trejo, Jo Ann
name: Weithäuser, Alice
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1–/– mice expressed reduced levels of IFN-β and CXCL10 during the early phase of infection compared with Par1+/+ mice that resulted in higher viral loads and cardiac injury at day 8 after infection. Inhibition of either tissue factor or thrombin in WT mice also significantly increased CVB3 levels in the heart and cardiac injury compared with controls. BM transplantation experiments demonstrated that PAR-1 in nonhematopoietic cells protected mice from CVB3 infection. Transgenic mice overexpressing PAR-1 in cardiomyocytes had reduced CVB3-induced myocarditis. We found that cooperative signaling between PAR-1 and TLR3 in mouse cardiac fibroblasts enhanced activation of p38 and induction of IFN-β and CXCL10 expression. Par1–/– mice also had decreased CXCL10 expression and increased viral levels in the lung after influenza A infection compared with Par1+/+ mice. Our results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection.