cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Phrynobatrachus Gunther 1862
Creators: name: Badjedjea, Gabriel
name: Masudi, Franck M.
name: Akaibe, Benjamin Dudu
name: Gvoždík, Václav
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Phrynobatrachidae
Phrynobatrachus

description: Phrynobatrachus Günther, 1862
The systematics of Congolian Phrynobatrachus is poorly known. We have identified three morphologically similar species in our Kokolopori material, all belonging to the P. auritus species complex. The identification of these frogs is complicated by the high level of color polymorphism and variation in their color patterns. For example, light stripes may be missing or may occur medially or laterally, sometimes bright spots (e.g., green) are distributed in different places, etc. This species complex is currently in taxonomic revision (V. Gvoždík et al., in prep.).
description: Published as part of Badjedjea, Gabriel, Masudi, Franck M., Akaibe, Benjamin Dudu & Gvoždík, Václav, 2022, Amphibians of Kokolopori: an introduction to the amphibian fauna of the Central Congolian Lowland Forests, Democratic Republic of the Congo, pp. 35-70 in Amphibian & Reptile Conservation (e 301) (e 301) 16 (1) on page 57, DOI: 10.5281/zenodo.12761585
Additional file 1: of Estimating the value of point-of-care HPV testing in three low- and middle-income countries: a modeling study
Creators: name: Campos, Nicole
name: Tsu, Vivien
name: Jeronimo, Jose
name: Mercy Mvundura
name: Kim, Jane
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary model documentation, methods, and results. This file includes detailed descriptions of the model calibration process, cost data, and supplementary results on the incremental net monetary benefit considering an alternative willingness-to-pay threshold. (DOCX 113Â kb)
The binary of Rousseau
Creators: name: Weaver, Theodore
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation began as a study of the relatively conventional, 18th century method of literary composition by rewriting the sentences of other writers.  Rousseau imitated sentence structure to compose with diverting rhythms and appropriate ideas from the literary canon.  The term “the binary of Rousseau” broadly means two writers coming together to make a passage; and words being defined in a way that contradicts their common signification.  The dissertation is essentially comparative because classical and modern writers were compared to Rousseau’s works.  From this perspective, Rousseau is understood as an Enlightenment author:  his oeuvre encompasses the standard philosophy of empiricism, rationalism, materialism and sensationalism, political theory and history.    My theory of composition with archetypes and prototypes is technical in the context of criticism about 18th century literature.  The first chapter evaluates Rousseau’s translation of Tacitus’s Le premier livre, a Roman historian.  Principles from the posthumously published Essai sur l’origine des langues are applied to aesthetics and linguistics.  In Chapter Two, more sentences of Rousseau’s translation of Tacitus are compared to Les confessions.  The formulaic practice of prototypal composition mystifyingly resembles that of translation which entails the systematic substitution of French words for Latin ones.  These chapters relied upon Genette’s Palimpsestes, a critical explanation of literature having to do with authors erasing words of original writers to compose over them.  Aristotle’s Poetics was an influence on Rousseau’s binary procedures, we know, because of his response to D’Alembert.  The third chapter about Romanticism, the epistolary novel, and sentimentality again takes up copying of the literary canon.  It compares Julie ou La Nouvelle Heloïse to The Gallic Wars of Julius Caesar.  In the fourth chapter, I take Chomsky and other linguists into account with portions of Du contrat social and Rousseau’s translation of Seneca’s Apocolocyntosis.  The final chapter about Dom Joseph Cajot’s Les plagiats and L’Émile ou de l’éducation describes how Rousseau digested Plato, Plutarch, Locke, Defoe, Condillac, etcetera and provides perspective about Rousseauian criticism from the 18th century to the present.
Asymptotic behavior of solutions to the conformal quotient equation
Creators: name: Wang, Yunpeng
Publisher: name: No Publisher Supplied
Year: 2013

description: We classify all radial admissible solutions to the conformal quotient equation on the  punctured Euclidean space and prove that an admissible solution to the conformal  quotient equation with an isolated singular point is asymptotic to a radial solution. We  also provide an alternative proof to obtain higher order expansion of solutions using  analysis of the linearized operators. This dissertation is based on a preprint of the  author [89].
Austrobalanidae Newman & Ross 1976
Creators: name: Chan, Benny K. K.
name: Dreyer, Niklas
name: Gale, Andy S.
name: Glenner, Henrik
name: Ewers-Saucedo, Christine
name: Pérez-Losada, Marcos
name: Kolbasov, Gregory A.
name: Crandall, Keith A.
name: Høeg, Jens T.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Thecostraca
Balanomorpha
Austrobalanidae

description: †FAMILY AUSTROBALANIDAE NEWMAN & ROSS, 1976
Diagnosis: Four-plated shells with thin-walled parietes; paries smooth internally, lacking ‘an inflected basal margin’; scutum without adductor ridge, articular ridge moderately prominent, adductor pits for depressor muscles absent; tergum with articular furrow wide, spur confluent with basirostral angle.
Comment: Chan et al. (2017a) conducted a molecular analysis of pachylasmatids, bathylasmatids and tetraclitids. Austrobalanus formed a basal relationship with the clade containing bathylamatids and tetraclitids. Molecular evidence therefore supports the family status of Austrobalanidae.
† Austrobalanus Pilsbry, 1916 (Eocene–Recent) (three species)
description: Published as part of Chan, Benny K. K., Dreyer, Niklas, Gale, Andy S., Glenner, Henrik, Ewers-Saucedo, Christine, Pérez-Losada, Marcos, Kolbasov, Gregory A., Crandall, Keith A. & Høeg, Jens T., 2021, The evolutionary diversity of barnacles, with an updated classification of fossil and living forms, pp. 789-846 in Zoological Journal of the Linnean Society 193 on page 836, DOI: 10.1093/zoolinnean/zlaa160, http://zenodo.org/record/5637275
Optimal upper bound for the infinity norm of eigenvectors of random matrices
Creators: name: Wang, Ke
Publisher: name: No Publisher Supplied
Year: 2013

description: Let $M7n$ be a random Hermitian (or symmetric) matrix whose upper diagonal and diagonal entries are independent random variables with mean zero and variance one. It is well known that the empirical spectral distribution (ESD) converges in probability to the semicircle law supported on $[-2,2]$. In this thesis we study the local convergence of ESD to the semicircle law. One main result is that if the entries of $M7n$ are bounded, then the semicircle law holds on intervals of scale $log n/n$. As a consequence, we obtain the delocalization result for the eigenvectors, i.e., the upper bound for the infinity norm of unit eigenvectors corresponding to eigenvalues in the bulk of spectrum, is $O(sqrt{log n/n})$. The bound is the same as the infinity norm of a vector chosen uniformly on the unit sphere in $R;n$. We also study the local version of Marchenko-Pastur law for random covariance matrices and obtain the optimal upper bound for the infinity norm of singular vectors. This is joint work with V. Vu.     In the last chapter, we discuss the delocalization properties for the adjacency matrices of  ErdH{o}s-R'{e}nyi random graph. This is part of some earlier results joint with L. Tran and V. Vu.
Godiva quadricolor
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Facelinidae
Godiva
Godiva quadricolor

description: Godiva quadricolor (Barnard, 1927)
(Figure 35 D–E)
Material examined. Six specimens. MB28-004588 & MB28-004589, ZDRS, 21 Jun. 2012, 30m, 18 and 22mm, respectively; MB28-004630, BL, 12 Oct. 2012, 3m, 32mm; MHN-YT944, ZDTR, 0.3m, 12mm; MB28-004916 & MB28-004917, NKA, 5 and 14mm, respectively.
Habitats. Subtropical tidal reef, seagrass and rocky reefs and tropical coral reefs.
Occurrences. Zavora, Barra and Nuarro.
Geographic distribution. Indo-west, central Pacific. Introduced in the Mediterranean and Atlantic Oriental (Cervera et al. 2010). Marshall Islands, Southern Japan, Mariana Islands, Papua New Guinea (Cervera et al. 2010), South Africa (Barnard 1927), Tanzania (Gosliner et al. 2008) and Mozambique (Gosliner 1987; Fraser 2001).
Remarks. In the specimens found by us the intensity of the blue on the head varied. The type locality of G. quadricolor is St James, False Bay, South Africa, although the centre of natural dispersion is uncertain (Cervera et al. 2010). This species is likely to have spread to the Mediterranean and Atlantic most likely as a result of shipping movements (Cervera et al. 2010), although this needs to be verified using molecular techniques.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 113, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Two-stage winner designs for non-inferiority trials with two to three experimental treatments and an active control
Creators: name: Wang, Pin-Wen
Publisher: name: No Publisher Supplied
Year: 2013

description: In drug development, two-stage winner design can be cost-effective when the best treatment is to be determined from multiple experimental treatments. In this design, an interim analysis is devised to select the best treatment to avoid high cost, long-term trial conduction, and exposure to ineffective treatments. When an existing effective treatment is available, but new experimental treatments have advantages such as less cost, easier delivery, less invasive and fewer side effects, etc., including placebo in the trial may be considered unethical. It is desirable to conduct a non-inferiority trial that directly compares new treatments with the existing treatment (active control), and show that the new treatments are not less effective than the active control by a certain amount (so called non-inferiority margin).    In this dissertation, we extended the framework of the two-stage winner design of Shun et al. (2008) to conduct non-inferiority tests. Specifically, we considered designs of trials with two or three experimental treatments and an active control. Our methods include superiority hypotheses as a special case, but the hypothesis setting is more general than that studied by Shun et al.. We studied the distribution of test statistics, cut-off values, sample size and power calculations using exact distribution of the test statistics as well as using normal approximations.  Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods.
Identification of novel Clic1 inhibitors for the treatment of cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: CLIC1 is overexpressed in most tumors including prostate cancer, muscle-invasive bladder cancer, pancreatic adenocarcinoma, glioma. Elevated CLIC1 expression correlates with poor prognosis. The peculiarity of CLICs, in particular of CLIC1, is it is mainly present as a cytosolic protein under physiological conditions and transiently expressed in the cell membrane during stress conditions. In prolonged stress conditions, the functional expression and the membrane activity of CLIC1 is no longer transient but becomes chronic and thus represents a unique pharmacological target. The integral membrane form of Clic1 is an active ion channel and transports Cl– into the cell as well as stimulates increase reactive oxygen species (ROS) production. These changes in intracellular localization and channel function, uniquely associated with malignant transformation offers a unique target for cancer therapy, likely able to engender specificity with reduced side effects. Moreover, studies have shown Clic1 inhibition, by a specific inhibitor, IAA94 reduces ROS production, decreased intracellular chloride levels and lowers cell motility and invasiveness of cancer cells. From the standpoint of developing new anti-cancer agents for preclinical evaluation IAA94 provides the ideal starting point as it was initially developed in 1987 as a diuretic but was not optimized for specific chloride channel activity. It has a good toxicity profile and established ADME/PK attributes. With an abundance of high-resolution crystallographic structures computational modeling of Clic1 shows clear opportunities for improvements in potency and selectivity over other chloride channels though medicinal chemistry optimization of IAA94. These new IAA94 analogues will also be designed and tested for ADME/PK attributes allowing in vivo assessment for anti-cancer activity. Compounds will be tested in established models of prostate cancer to determine cellular localization and functional effects on proliferation. Following iterative cycles of model-build-test (in vitro) the assessment of improved Clic1 inhibitors in vivo will be used to validate our proposal that this structural class of compounds provides new lead compounds with anti-cancer activity and a good toxicological profile. In summary, Clic1 inhibition is an exciting therapeutic strategy with great potential in a broad spectrum of cancer types.
Illuminating the fluid connection between Wnt signaling and the centrosome in colorectal cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Colorectal adenocarcinoma (CAC) is a deadly cancer with few promising treatment modalities. The overwhelming majority of patient CACs stem from loss-of-function mutations that result in runaway activation of the canonical Wnt signaling pathway and proliferation of gut epithelium. In healthy gut tissue, Wnt pathway activation is tightly controlled by a protein condensate, the Destruction Complex (DC), which degrades the transcriptional co-activator β-catenin and prevents aberrant activation of proliferative genetic programs. Intriguingly, the most common CAC mutation is a large deletion that results in the loss of DC liquid-liquid phase separation (LLPS). While the precise mechanism through which the DC regulates β-catenin is unknown, it is clear that DC function is perfectly correlated with LLPS. Recent work in our lab has uncovered that the centrosome, the structure that orchestrates chromosomal segregation and cell-cycle progression during cell division, nucleates DC droplets consequently regulating droplet volume and localization as a function of the cell-cycle. This finding is the first evidence that DC structure and Wnt signal transduction are directly related to cell-cycle progression and provides a potential mechanism of CAC progression. The present proposal thus seeks to elucidate this novel relationship by addressing the following questions: 1) What role does centrosome nucleation of DC proteins play on Wnt signal transduction? 2) How do they change in response to cell cycle progression, and 3) How do the biophysical properties of the DC compare between healthy and CAC tissues? Using optogenetic tools that allow us to control the DC LLPS with light we will map the DC phase diagram and signaling output in live, single cells. We will then characterize DC dynamics and Wnt signaling function in cell cycle synchronized cell populations. These experiments will then be repeated in a patient-derived CAC epithelial cell line bearing the common loss-of-function mutation that inhibits condensate formation. By understanding the connection between the biophysical properties and signaling outcomes of the Wnt pathway and their connection to cell cycle progression, in wild-type and cancer cells, we will support the development of therapeutics that more precisely target the pathological mutations that lead to cancer.
Modal primitivism
Creators: name: Wang, Jennifer
Publisher: name: No Publisher Supplied
Year: 2013

description: Modal primitivism is the view that there are modal features of the world which cannot be reduced to the non-modal. Theories which embrace primitive modality are often rejected for reasons of ideological simplicity: the fewer primitive notions a theory invokes, the better. Furthermore, modal primitivism is often associated with the view that all modal features of the world are irreducibly modal, which appears unsystematic and unexplanatory. As a result, many prefer modal reductionism. This work is an articulation and defense of a modal primitivist theory of modality which requires minimal ideology and is systematic and explanatory. On this version of modal primitivism, only some modal features of the world are irreducibly modal—namely, incompatibilities between certain properties or relations. Other modal features of the world are reducible to a combination of primitive incompatibilities and the non-modal features of the world. In chapter 1, I introduce various issues in the metaphysics of modality, giving appropriate background for what follows. My modal primitivist theory of modality is introduced in chapters 2 and 3. In chapter 2, I argue that a well-known modal reductionist theory of modality is not as ideologically innocent as it’s thought to be: modal primitivism has the upper hand with respect to primitive notions. I then introduce the primitive notion of incompatibility and show how this notion can be used to account for de dicto modality, which concerns purely qualitative modal claims. In chapter 3, I present a theory of de re modality, that which concerns modal claims involving particular individuals. Since on this theory the de re is reducible to the de dicto, it requires no more primitive modality than that which appears at the level of the de dicto. I end in chapter 4 by arguing against a rival modal primitivist theory, showing that the primitive notion that it countenances, dispositionality, cannot account for all modal claims.
Moridilla brockii Bergh 1888
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Facelinidae
Moridilla
Moridilla brockii

description: Moridilla brockii Bergh, 1888
(Figure 35 F)
Material examined. Five specimens. MB28-004500, ZRP, 21 Fev. 2012, 1m, 14mm. MHN-YT266, ZRP, 21 Feb. 2012, 2m, 31mm. MB28-004545, ZSC, 14 May 2012, 22m, 9mm. MB28-004559, ZRP, 0 4 Jun. 2012, 1m, 28mm. MB28-004925, ZRP, 19 Aug. 2014, 0.5m, 18mm.
Habitats. Subtropical tidal reefs and rocky reefs.
Occurrences. Zavora.
Geographic distribution. Indo-west Pacific. Solomon Islands, Papua New Guinea, Philippines, Malaysia (Gosliner et al. 2008), Australia (Nimbs & Smith 2016), India (Ramakrishna et al. 2010), Maldives, Seychelles (Yonow 1994), South Africa (Gosliner et al. 2008) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 114, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Design and fabrication of salicylic acid-based polyanhydride devices for wound healing and tissue regeneration
Creators: name: Snyder, Sabrina Sachiko
Publisher: name: No Publisher Supplied
Year: 2013

description: Wound healing and tissue regeneration after injury is regulated by inflammatory response degree and duration.   Localized, controlled release of anti-inflammatory drugs at the injury site can modulate inflammation, thereby, controlling the wound healing process.  This research uses salicylic acid-based poly(anhydride-esters) (SAPAEs) to release salicylic acid (SA), an anti-inflammatory drug, in a controlled manner for wound healing and tissue regeneration applications.   In the first studies, SAPAE-containing bone regeneration devices were developed.  SAPAEs were melt-cast as guided bone regeneration (GBR) caps onto osteoconductive scaffolds, then in vitro drug release was quantified.  In vivo inflammation and bone regeneration capacity were evaluated.  The SAPAE caps suppressed inflammation and had no effect on bone formation in a rabbit cranial trephine defect model.   Second, SAPAEs were blended with polycaprolactone (PCL) and electrospun to create flexible GBR mats.  Electrospun mat structure, mechanical properties, and in vitro drug release were determined.  Mats were assessed in vivo for their ability to prevent heterotopic ossification (HO) in a rat femoral defect model.  Initial studies indicate that the SAPAE:PCL blends prevent HO, but also inhibit bone regeneration in the defect site.   Third, SAPAE:poly(ethylene glycol) (PEG) copolymers at various ratios were developed for fibrous adhesion prevention.  These, copolymers behave as viscous liquids at room temperature.  Rheological properties, in vitro drug release profiles, cytotoxicity, and anti-inflammatory activity were assessed.  Shear viscosities are comparable with FDA-approved fibrous adhesion barriers and have the additional benefit of drug release to modulate the excessive inflammation that causes adhesion formation.   Fourthly, SAPAEs exhibit an initial lag period in drug release, which could be unfavorable in applications where immediate SA release is desired.  By varying the amounts of small molecules incorporated into an SAPAE matrix with an 11-day lag period, immediate and constant SA release profiles were achieved.   Overall, SAPAEs were utilized to create bone scaffolds and wraps to direct bone growth, as injectable adhesion barrier devices, and to control early SA release.  All these approaches were focused on controlling the wound healing process with biodegradable SAPAEs.
Small Molecule Targeting of GNAS for the Treatment of Mucinous Adenocarcinoma of the Appendix
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The Gα protein GNAS is the second most frequently mutated gene in mucinous adenocarcinoma of the appendix (~50% of tumors), an orphan disease with no FDA approved systemic therapy. Genetic studies have confirmed that mutations in the R201 codon of GNAS drive oncogenesis in appendiceal, colon, and gastric adenocarcinoma, as well as Intraductal Papillary Mucinous Neoplasms (IPMN) of the pancreas and Small Cell Lung Cancer (SCLC). Although classically druggable, no commercially available inhibitors of GNAS currently exist. Here, we propose an innovative approach to develop and characterize chemical inhibitors of GNAS. Given prior in vitro and in vivo data demonstrating that GNAS knockout is lethal to GNASR201 tumors, there is a high likelihood that chemical inhibition of GNAS will be an effective therapeutic strategy for GNASR201 tumors.
 Structure based approach to designing the needed modulators of GNAS mutant is a highly promising path to finding drug candidates to treat patients with GNAS mutations. With two of the most druggable pockets identified we will perform a screen against the largest chemical catalog of a billion compounds. The top hits characterized by the neural network force field-based docking score, as well as desirable ADME/Tox characteristics, will be obtained or synthesized and experimentally tested. In parallel, a de novo compounds based on docking predictions, will be synthetized and evaluated. The first hits will be derivatized, synthesized and tested through iterative cycles of model-build-test allowing continued refinement of our pocket targeting small molecules arriving at a set of compounds at the end of this study that will validate our targeting of these sites for selective chemotherapy.
 Our previous experience in discovering first in class compounds for newly identified pockets (e.g., recently published inhibitors of CK2 alpha/beta interface, HepC protease inhibitors) is a good illustration of our ability to find drug candidates for this important target. As well as our proven track record synthesizing target small molecules quickly and efficiently. The team is led by a synthetic chemist (Dr. Dionicio Siegel, UCSD) with full support from a computational chemist (Dr. Ruben Abagyan, UCSD) and cancer clinician (Dr. John Paul Shen, MD Anderson Cancer Center).
Using electrical chemical impedance spectroscopy to determine nanocapillary geometry and differential capacitance by developing a variable topology network circuit model
Creators: name: Vitarelli, Michael J.
Publisher: name: No Publisher Supplied
Year: 2013

description: Nanocapillaries  nd increasing use in a variety of applications including, protein translo-  cation dynamics, protein sequencing, and other nano  uidic studies. All of these appli-  cations are a ected by the geometry of the nanopore and the molecular species found  within. This dissertation develops a new equivalent circuit model to determine the  geometry of nanocapillaries. This model is derived to include the e ects of a varying  nanocapillary radius, along with the capacitive double layer within the nanocpaillary.  The model is tested by using electrochemical impedance spectroscopy on a nanocapil-  lary array membrane. The resulting values extracted from the model  t are consistent  with the manufacturer's speci ed geometry. The model is then further developed to  determine the impedance of proteins. This is accomplished by modeling the protein as  a cylinder and inserting this into our above mentioned model. By exploiting alternat-  ing regions of surface charge density on the protein this model will allow for the rapid  sequencing of proteins.
Iron Curtain, iron lungs
Creators: name: Vargha, Dora
Publisher: name: No Publisher Supplied
Year: 2013

description: Iron Curtain, Iron Lungs uses the series of polio epidemics in communist Hungary to study a global public health emergency in the midst of an international political crisis: the Cold War. Based on extensive, thus far unexplored archival material, medical and popular literature, newspapers, audiovisual sources, memoirs and oral history interviews, the dissertation argues that due to the particularities of polio, unique spaces of cooperation opened between antagonistic sides while Cold War concepts simultaneously influenced policies and practices of disease prevention and treatment. Polio became an issue that reached over Cold War divisions, due to four attributes of the disease: the new phenomenon of epidemic polio in the 20th century; the importance of children as the main age group of the disease; the debilitating effects of the virus; and that polio was a global disease.  The dissertation analyses the history of polio in Hungary at multiple registers. On an international level, it asks how Cold War divisions can be re-evaluated when viewed through the lens of a disease that disregarded borders and ideologies. On a national level, the dissertation investigates how post-war societies and nascent political systems dealt with an epidemic that worked against their modernist projects. On an individual level, it raises questions about definitions of treatment, authority of care and investigates the boundary between professional and lay knowledge.  Iron Curtain, Iron Lungs presents a new approach both to Cold War history and to the history of medicine. The dissertation shifts attention from the two superpowers to an Eastern European state and by doing so, throws new light on Cold War interactions and the effect of international politics on personal experiences. The unique geopolitical situation of Hungary on the boundary of the Iron Curtain and the construction of a new communist regime makes the country the ideal ground to understand the influence of Cold War in forming global health responses to epidemic crises. With vaccine first arriving from the West, followed by a new serum from the East, the Hungarian story highlights issues of international politics, experimentation and standardization in epidemic prevention. Furthermore, a focus on Hungary allows linking the intimate world of families with national and international agendas through the care for disabled children with polio.
Phrynobatrachus auritus Boulenger 1900
Creators: name: Badjedjea, Gabriel
name: Masudi, Franck M.
name: Akaibe, Benjamin Dudu
name: Gvoždík, Václav
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Phrynobatrachidae
Phrynobatrachus
Phrynobatrachus auritus

description: Phrynobatrachus cf. auritus Boulenger, 1900
Fig. 10C.
Area: Yalokole.
Season/survey: Wet (May 2018).
Material: CSB:Herp: RNBK 066, 101.
Comments: The type locality of this species is far from the study site, in Equatorial Guinea (Sánchez-Vialas et al. 2020), thus this identification still needs to be tested by molecular methods. Individuals corresponding to this species were found only near the Eho stream, in the neighborhood of the Bandjangi swamp (used by local people to macerate cassava) at the edge of disturbed forest and farmbush, near Yalokole village. This record could indicate a higher level of tolerance to disturbed habitats, as the other two species were found only in primary forest. The general coloration of this species appears to be rather lighter, with a mostly pale, whitish venter.
description: Published as part of Badjedjea, Gabriel, Masudi, Franck M., Akaibe, Benjamin Dudu & Gvoždík, Václav, 2022, Amphibians of Kokolopori: an introduction to the amphibian fauna of the Central Congolian Lowland Forests, Democratic Republic of the Congo, pp. 35-70 in Amphibian & Reptile Conservation (e 301) (e 301) 16 (1) on page 57, DOI: 10.5281/zenodo.12761585
Balanoidea Leach 1817
Creators: name: Chan, Benny K. K.
name: Dreyer, Niklas
name: Gale, Andy S.
name: Glenner, Henrik
name: Ewers-Saucedo, Christine
name: Pérez-Losada, Marcos
name: Kolbasov, Gregory A.
name: Crandall, Keith A.
name: Høeg, Jens T.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Thecostraca
Balanomorpha

description: SUPERFAMILY BALANOIDEA LEACH, 1817
Diagnosis: Wall composed of rostrum, carina and one to two pairs of marginals, or wholly concrescent; parietes solid or tubiferous; radii solid or tubiferous; basis commonly calcareous, solid or permeated by tubes, rarely membranous; when basis calcareous, internal surfaces of compartments commonly with uniform ribs and interdigitations with wall; mandible quadri- or quinquidentate; caudal appendages absent; penis with basidorsal point; first three pairs of cirri are maxillipeds.
C o m m e n t s: T h e s p e c i e s a t p r e s e n t a n a l y s e d molecularly form two distinct clades that are here recognized as the Balanidae and Pyrgomatidae. Relationships of the many species within each of these are much less clear and clearly in need of future analysis by molecular methods.
description: Published as part of Chan, Benny K. K., Dreyer, Niklas, Gale, Andy S., Glenner, Henrik, Ewers-Saucedo, Christine, Pérez-Losada, Marcos, Kolbasov, Gregory A., Crandall, Keith A. & Høeg, Jens T., 2021, The evolutionary diversity of barnacles, with an updated classification of fossil and living forms, pp. 789-846 in Zoological Journal of the Linnean Society 193 on page 836, DOI: 10.1093/zoolinnean/zlaa160, http://zenodo.org/record/5637275
The Sala Bologna in the Vatican Palace
Creators: name: Urban, Emily
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation examines the ceiling fresco of the Sala Bologna in the Vatican Palace commissioned by Pope Gregory XIII in 15&5.  Portrayed on the vault is an uninterrupted view of the entire celestial sphere with each constellation represented in allegorical form and accurately placed with relation to one another.  Each aspect of the ceiling’s iconography is explored in detail, including the frieze of mythical gods and ancient astronomers painted in the curves of the vault below.   I also consider the relationship between this celestial fresco and the terrestrial maps of Bologna painted on the lower walls of the room.  Through an interpretation of the room as a single decorative program, I establish that the imagery of the Sala Bologna visually demonstrates Gregory XIII’s use of empiricism to further his Post-Tridentine goals of Catholic reform.  Moreover, it is my belief that this ceiling asserts the temporal and spiritual claims of the Church in a language that anticipates the increasingly important role of empirical science for the seventeenth-century papacy.       The second goal of this dissertation is to contextualize the astronomical ceiling of the Sala Bologna within the tradition of celestial iconography.  Although individual astrological frescoes have been explored in previous scholarship, there has been no explanation for the popularity of this imagery in the Renaissance and Baroque periods.  By discussing over thirty celestial murals, I highlight several major themes and provide insight into the motivation behind the commission of this type of decoration.
ROLE OF IMMUNOLOGICAL EXPERIENCE SHAPING T CELL REACTIVITY IN TUMORS
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Mice have been invaluable in discovering fundamental tumor immunology principles, model processes, and test anti-cancer immunotherapies at a pre-clinical stage. However, laboratory mice are usually kept in specific pathogen-free (SPF) conditions resulting in limited immune stimulation, while humans are exposed to natural pathogens and commensals throughout life. Such a different “immunological experience” has extreme consequences on the maturation of the immune system. SPF mice resemble newborn humans in that naïve T cells predominate, and tissue-resident adaptive immunity has not developed. Some of the immunomodulatory drug tests conducted in SPF mice have been dramatically misleading. For instance, SPF mice failed to predict the cytokine storm ensuing the administration of CD28 superagonist in humans, which could only be reproduced in immune-experienced mice after patients experienced life-threatening side effects. This application for a pilot grant through CRCC hypothesizes that immune experience increases CD8+ T cell reactivity within tumors. In contrast, modifications in T regulatory (Treg) cell reactivity may be absent or present. Tipping the balance towards CD8 reactivity would facilitate tumor rejection, especially after PD-1 immunotherapy. We will test this hypothesis by combining two state-of-the-art technologies. We have cutting-edge capabilities and experience in measuring TCR-mediated activation in tumor-associated CD8, CD4, and Treg cells in living mice using intravital multiphoton microscopy. We will combine this with C57BL/6 mice rederived to feral mice (wildling mice) to harbor the natural microbiome, mycobiome, and virome while being inbred and on a common genetic background. We collaborate with Prof. Rehermann of the NIH to import wildling mice to UCI and have an approved IACUC protocol to use them. We will first measure tumor-associated CD8+ and Treg cell reactivity in SPF as compared to wildling mice. We will then establish a correlation between tumor CD8+ and Treg cell reactivity in wildling mice and enhancement of their function and cancer rejection, either spontaneous or induced by PD-1 blockade. Our investigation will help identify the most suitable mouse model to study T cell immunology in cancer and shed light on the connection between immune experience and the quality of T cell responses to tumors.
Phrynobatrachus giorgii De Witte 1921
Creators: name: Badjedjea, Gabriel
name: Masudi, Franck M.
name: Akaibe, Benjamin Dudu
name: Gvoždík, Václav
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Phrynobatrachidae
Phrynobatrachus
Phrynobatrachus giorgii

description: Phrynobatrachus cf. giorgii De Witte, 1921
Fig. 10B.
Area: Bechuchuu, Yalokole.
Season/survey: Wet (May 2018, Nov 2018), dry (Aug 2019, Jul 2020).
Material: CSB:Herp: RNBK 254, 718, 737, 761, 762, 855, 856, 857, 858, 859, 860, 861; IVB-H-CD 18190, 18237, 18238, 18283, 18284, 18297, 18298, 18300; possible hybrids: IVB-H-CD 18186, 18188.
Comments: Individuals of this species morphologically correspond to the type material of P. giorgii. However, the type locality (Yambata) is north of the Congo River and therefore the identification must still be tested genetically. This species was found at several sites, always in primary forest and usually near small streams or swampy places in flooded forest. Some males were found calling from moist leaf-litter. Depending on the physiological conditions, this species may have smooth skin, but quite often has slightly warty skin. It is very variable in color tones (and patterns), but often has a lighter background (reddish to brown) suffused with black. One specimen (adult female) was very dark, almost black, on the dorsum and darkly marbled on a white venter. Adult males have black throats. This relatively small-sized species was found in syntopy with another Phrynobatrachus, a slightly larger and generally lighter species resembling P. auritus (P. sp. aff. auritus, see below). As some individuals had intergrading traits, it is possible that the two species hybridize, but this needs to be confirmed genetically.
description: Published as part of Badjedjea, Gabriel, Masudi, Franck M., Akaibe, Benjamin Dudu & Gvoždík, Václav, 2022, Amphibians of Kokolopori: an introduction to the amphibian fauna of the Central Congolian Lowland Forests, Democratic Republic of the Congo, pp. 35-70 in Amphibian & Reptile Conservation (e 301) (e 301) 16 (1) on page 57, DOI: 10.5281/zenodo.12761585
Multiparametric 18F-fluciclovine PET imaging in evaluation of recurrent glioblastomas
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Assessment of response to treatment in glioblastoma (GB) is a clinical dilemma. Residual/recurrent tumor could mimic pseudoprogression, radiation necrosis and other treatment-related changes. Although pathological confirmation is the most reliable method to differentiate progressive tumor from treatment effect, it is an invasive method and may not correctly target the viable part of the tumor; therefore, numerous noninvasive methods have been attempted, including several MRI tools , and various PET tracers(1).
 Yet, current imaging techniques are often inconclusive. 18F-fluciclovine (Axumin®; Blue Earth Diagnostics), a synthetic amino acid mostly used as a PET tracer in prostate cancer has recently shown value in differencing disease progression and treatment-related changes (2)(3). Its high tumor-to-brain contrast based on the relatively high specificity for neoplastic tissue and the low uptake in healthy brain tissue make 18F-fluciclovine an attractive agent with significantly higher image contrast compared to other amino acid PET tracers(4). Nevertheless, most studies focused on static imaging features, which provide a simple snapshot of radiopharmaceutical concentration within the neoplasms and do not provide sufficient information on tumor perfusion and tracer kinetics that may be important in differentiating active tumor from treatment changes. Dynamic PET imaging utilizing other tracers such as O-(2-[18F]fluoroethyl)-L-tyrosine, ¹¹C-methionine, and 3,4-dihydroxy-6-[¹⁸F]fluoro-L-phenylalanine have shown potential in assessment of response to therapy in brain tumors (5)(6)(7). 18F-fluciclovine has several advantages compared to these tracers, including it is already widely available, has appropriate half-life for usage in clinical practice, and FDA approved.
 To the best of our knowledge, no study has evaluated the usefulness of 18F-fluciclovine dynamic PET in assessing treatment response in GB, utilizing the world’s first EXPLORER total-body PET/CT scanner, which offers ultrahigh sensitivity and more accurate tracer kinetic analysis(8).
 The aims of this pilot study are (i) to investigate the feasibility of parametric 18F-fluciclovine brain PET imaging in differentiating progressive disease from treatment effect and (ii) to validate the feasibility of the 18F-fluciclovine cerebral perfusion using MRI perfusion imaging as the reference.
MOESM1 of Continuous seismic monitoring of Nishinoshima volcano, Izu-Ogasawara, by using long-term ocean bottom seismometers
Creators: name: Shinohara, Masanao
name: Ichihara, Mie
name: ShinâIchi Sakai
name: Yamada, Tomoaki
name: Takeo, Minoru
name: Sugioka, Hiroko
name: Nagaoka, Yutaka
name: Akimichi Takagi
name: Taisei Morishita
name: Tomozo Ono
name: Nishizawa, Azusa
Publisher: name: Figshare
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 1. Detection, location of characteristic events and comparison with aerial observations.
Targeting thermogenesis regulators in pancreatic cancer-associated cachexia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A majority of patients with advanced cancer develop a condition called cancer cachexia, leading to severe weight loss that cannot be treated by simply increasing food intake. Cancer cachexia diminishes physical function and quality of life and is estimated to directly account for 20% of cancer-related deaths. At present, there is no effective therapy. Cancer cachexia is especially prominent in pancreatic ductal adenocarcinoma (PDA), which carries a poor prognosis and is projected to become the second leading cause of cancer-related death in the U.S. by 2030. A vast majority (80%) of patients with PDA have lost more than 10% of body weight at the time of diagnosis and the more pronounced the degree of cachexia, the worse is the chance of survival. Recent research indicates that a major driver of weight loss in cancer cachexia is increased energy burning (also called thermogenesis) by specialized fat cells. These energy-burning fat cells become more numerous and active and so more calories are lost. At the same time, regular energy-storing fat cells and muscle shrink. Exactly why this happens and whether restoring fat cells to normal can be beneficial is not known. Our proposed research for this grant deals with two genes that we recently discovered to control the conversion of regular fat cells into energy-burning fat cells. One gene increases the conversion while the other gene blocks the conversion. We proved this by removing each gene to make genetic knockout mice and studying their fat cells. With these knockout mice, we can now test whether blocking the conversion of regular fat to energy-burning fat will reduce the severity of cachexia associated with pancreatic cancer. This could lead to new treatment strategies to combat cancer cachexia.
Balanidae Leach 1817
Creators: name: Chan, Benny K. K.
name: Dreyer, Niklas
name: Gale, Andy S.
name: Glenner, Henrik
name: Ewers-Saucedo, Christine
name: Pérez-Losada, Marcos
name: Kolbasov, Gregory A.
name: Crandall, Keith A.
name: Høeg, Jens T.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Thecostraca
Balanomorpha
Balanidae

description: FAMILY BALANIDAE LEACH, 1817
Diagnosis: Monophyletic by molecular analysis. Wall of six or four plates; parietes tubiferous or solid; tubiferous shell, with tubes basically in a single uniform row formed between inner and outer laminate, although supplementary tubes may form basally; interlaminate figures complex, arborescent; radii either solid or tubiferous; basis commonly calcareous and tubiferous or membranous.
Comments: There are no clear morphologically based apomorphies for this family compared with the Pyrgomatidae. The genus Wanella is sister group to all remaining species as yet analysed by molecules, and this could argue for a separation within two subfamilies. Many genera are polyphyletic, and more low-level taxonomic revision is therefore needed.
description: Published as part of Chan, Benny K. K., Dreyer, Niklas, Gale, Andy S., Glenner, Henrik, Ewers-Saucedo, Christine, Pérez-Losada, Marcos, Kolbasov, Gregory A., Crandall, Keith A. & Høeg, Jens T., 2021, The evolutionary diversity of barnacles, with an updated classification of fossil and living forms, pp. 789-846 in Zoological Journal of the Linnean Society 193 on page 836, DOI: 10.1093/zoolinnean/zlaa160, http://zenodo.org/record/5637275
Phidiana bourailli
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Facelinidae
Phidiana
Phidiana bourailli

description: Phidiana bourailli (Risbec, 1928)
(Figure 35 G)
Material examined. Seven specimens. MB28-004494, ZRP, 21 Feb. 2012, 2mm, 12m; MHN-YT341, ZRP, 0 6 May 2012, 1m, 8mm; MB28-004563, ZRP, 0 6 Jun. 2012, 1m, 5mm; MB28-004576, ZRP, 18 Jun. 2012, 1m, 6mm; MB28-004966, ZRP, 21 Feb. 2015, 0.5m, 7mm; MB28-004992, 2 spcs., ZRP, 0 5 May 2015, 0.3m, 4mm.
Habitats. Subtropical tidal reefs.
Occurrences. Zavora.
Geographic distribution. Indo-west Pacific. New Caledonia, Papua New Guinea, Australia (Nimbs et al. 2015), Philippines, Madagascar (Gosliner et al. 2008), South Africa (Gosliner 1987) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 114, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168