cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Machine learning model demonstrates stunting at birth and systemic inflammatory biomarkers as predictors of subsequent infant growth – a four-year prospective study
Creators: name: Harrison, Elizabeth
name: Syed, Sana
name: Lubaina Ehsan
name: Najeeha T. Iqbal
name: Sadiq, Kamran
name: Fayyaz Umrani
name: Sheraz Ahmed
name: Najeeb Rahman
name: Jakhro, Sadaf
name: Ma, Jennie Z.
name: Hughes, Molly
name: S. Asad Ali
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file 1. Supplementary Methods.
On Nica-Pimsner algebras of C*-dynamical systems over $\mathbb{Z}_+^n$
Creators: name: Kakariadis, Evgenios T. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 46L05, 46L55, 46L30, 58B34

description: We examine Nica-Pimsner algebras associated with semigroup actions of $\mathbb{Z}_+^n$ on a C*-algebra $A$ by $*$-endomorphisms. We give necessary and sufficient conditions on the dynamics for exactness and nuclearity of the Nica-Pimsner algebras. Furthermore we parameterize the KMS states at finite temperature by the tracial states on $A$. A parametrization is also shown for KMS states at zero temperature (resp. ground states) by the tracial states on $A$ (resp. states on $A$). Finally we give a formula for obtaining tracial states on the Nica-Pimsner algebras.
description: 43 pages; minor corrections; close to publication
Shaping the uptake of cloud-to-edge based services to support industrial use cases
Creators: name: Giuffrida, Maria
name: Pourabdollahian, Golboo
name: Seifert, Inessa
name: Dietrich, Mark
name: de Block, Tom
name: Timmermann, Hauke
Publisher: name: Zenodo
Year: 2023
Subjects: cloud
edge
iot
industrial use cases
value-chain adopters

description: The second UNLOCK CEI webinar was the occasion to present the activities towards the creation of an engaged community of CEI adopters to help understand the requirements for the future uptake of such technologies and provide insights to guide future research and innovation in this field. The event opened the first wave of Value Chain Adopter workshops scheduled between February and March 2023. The attached slides were presented at the event Learn more on the initiative: wwww.eucloudedgeiot.eu
Associations between personal apparent temperature exposures and asthma symptoms in children with asthma
Creators: name: Zhang J.J.
name: Li Z.
name: Evans S.
name: Zhou X.
name: Li F.
name: He L.
name: Bergin M.H.
name: Norris C.
name: Cui X.
name: Zhang Y.
name: Black M.
name: Barkjohn K.
Publisher: name: Public Library of Science
Year: 2023

description: Ambient temperature and relative humidity can affect asthma symptoms. Apparent temperature is a measure of temperature perceived by humans that takes into account the effect of humidity. However, the potential link between personal exposures to apparent temperature and asthma symptoms has not been investigated. We conducted a panel study of 37 asthmatic children, aged 5–11 years, during an early spring season (average daily ambient temperature: 14C, range: 7–18C). Asthma symptoms were measured 4 times for each participant with a 2-week interval between consecutive measurements using the Childhood Asthma-Control Test (C-ACT). Average, minimum, and maximum personal apparent temperature exposures, apparent temperature exposure variability (TV), and average ambient temperature were calculated for the 12 hours, 24 hours, week, and 2 weeks prior to each visit. We found that a 10C lower in 1-week and 2-week average & minimum personal apparent temperature exposures, TV, and average ambient temperature exposures were significantly associated with lower total C-ACT scores by up to 2.2, 1.4, 3.3, and 1.4 points, respectively, indicating worsened asthma symptoms. Our results support that personal apparent temperature exposure is potentially a stronger driver than ambient temperature exposures for the variability in asthma symptom scores. Maintaining a proper personal apparent temperature exposure could be an effective strategy for personalized asthma management. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Classical Radiation Reaction in Particle-In-Cell Simulations
Creators: name: Vranic, Marija
name: Martins, Joana L.
name: Fonseca, Ricardo A.
name: Silva, Luis O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Under the presence of ultra high intensity lasers or other intense electromagnetic fields the motion of particles in the ultrarelativistic regime can be severely affected by radiation reaction. The standard particle-in-cell (PIC) algorithms do not include radiation reaction effects. Even though this is a well known mechanism, there is not yet a definite algorithm nor a standard technique to include radiation reaction in PIC codes. We have compared several models for the calculation of the radiation reaction force, with the goal of implementing an algorithm for classical radiation reaction in the Osiris framework, a state-of-the-art PIC code. The results of the different models are compared with standard analytical results, and the relevance/advantages of each model are discussed. Numerical issues relevant to PIC codes such as resolution requirements, application of radiation reaction to macro particles and computational cost are also addressed. The Landau and Lifshitz reduced model is chosen for implementation.
description: 12 pages, 8 figures
One-pot sequential diprop-2-ynylation and cycloaddition: An efficient synthesis of novel N,N-bis(1,2,3-triazol-4-yl) methylarylamines starting from primary amines
Creators: name: He, Zhu-Jun
name: Wei, Mei-Hong
name: Zhang, Xiao-Lan
name: Chen, Jun-Min
name: Shou-Ri Sheng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: A facile, one-pot synthesis strategy for the tertiary arylamines bearing N,N-bis(1,2,3-triazol-4-yl)methyl structure has been developed by sequential diprop-2-ynylation of primary amines with propargyl bromide in the presence of calcium hydride in DMF and [3 + 2] “click” cycloaddition with organic azides promoted by cupric acetate in the mixed DMF-H2O media. This protocol provides some features, such as high efficiency and regioselectivity, easy operation, and moderate to good product yield (56–84%) with a wide substrate scope under mild conditions.
Utaxatax gereckei Panesar 2004
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Anisitsiellidae
Utaxatax
Utaxatax gereckei

description: Utaxatax gereckei Panesar, 2004
Records from the study area: Himachal Pradesh—Panesar (2004).
Habitat: In cascades with mosses and second-order mountain streams.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 11, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
High-degree modes in the southern pole star: The δ Scuti star σ Octantis
Creators: name: Pollard, Karen
name: Rea, Bill
name: Gunn, Fraser
name: Luisi, Jaime
name: Zhou, Yixiao
Publisher: name: Zenodo
Year: 2024

description: We report on a spectroscopic and photometric study of the δ Scuti variable star σ Octantis, which has been reported to be a hybrid δ Scuti /γ Doradus star previously. A large set of 350 high-resolution spectra were obtained with the 1-metre McLellan Telescope and HERCULES spectrograph at the University of Canterbury Mt John Observatory and these have been supplemented by an analysis of an extensive data set of photometric observations obtained during four Antarctic winters, as well as several TESS sectors of observations. From the spectra, a value of 100 km/s was obtained for the vsini. For the spectra, frequency analysis and mode identfication were carried out with SigSpec and FAMIAS. Many of the dominant frequencies were also seen in the photometry, and variable amplitudes of some frequencies was noted. Notably, the dominant photometric frequency (10.49 c/d) was detected in the spectroscopy, but was not the strongest frequency. Spectroscopic mode identification showed that most modes were prograde high-degree (l ≥ 9) modes. No evidence for a radial mode was found. In order to gain further insights into the pulsation modes in this star, we have started to model this star using iSpec (to refine the fundamental stellar parameters) and MESA/GYRE (to identify and confirm the pulsation frequencies and mode identifications).
A study on Sustainable Water Management Systems in view of UN SDG 6 centering advanced ICTs
Creators: name: Afridi, Waqas
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Implementation of advanced Information and Communication Technologies (ICTs) in water-reliant process industry to effectively practice Sustainable Water Management (SWM) is a rising global issue mainly due to the population growth and ageing of infrastructures. Global manufacturers such as food & beverages, textile fabrics, and pharmaceuticals consumes high amount of raw water and energy in their production processes such as fabricating, washing, diluting, producing medicines, and more alike industrial operations. For this, a new generation of innovative analytical tools offer wide range of opportunities to address these challenges and to transform raw data into actionable intelligence at both the tactical and strategic levels. This research is focused towards addressing three core objectives. First, to critically review the potential of emerging advanced ICT tools in water-reliant manufacturing sector. Second, to strongly advocate the SWM efforts of leading global manufacturers in Pakistan. Third, to develop a computer-aided simulation model of a pilot water treatment plant using MATLAB/Simulink software. The results of the study reveal that, the performance and durability of RO treatment section is chiefly determined by the robust pretreatment organic filtration methods, where the main operational parameters such as volumetric flow rate, solute concentrations, and change in pressures across RO unit have been instrumental in optimization of plant performance and act as a driving force in enhancing system efficiency. In particular, the study is a contribution in the field of ICT sensor applications in process engineering.
Intervalos de referencia para 25-hidroxivitamina D en población autóctona y aparentemente sana de Yucatán
Creators: name: García-Gonzáleza, Lorena Aurora Ek-Macías, Roger Iván López-Díaz, Aurea Noemí Yerves Sosa, Adrián Alejandro Ceballos-López y María E. López-Novelo, Igrid
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320202
subject: Clinical chemistry (incl. diagnostics)

description: Introducción: La 25-hidroxivitamina D [25(OH)D] se considera un marcador del estado general de salud y su deficiencia es un problema a nivel mundial. En la actualidad no existe un consenso para definir sus niveles óptimos, siendo necesario establecerlos para cada población de acuerdo con sus características étnicas y factores ambientales a los que está expuesta. Objetivo: Determinar los intervalos de referencia para 25(OH)D en población autóctona y aparentemente sana de Yucatán. Métodos: Se estudiaron 71 voluntarios aparentemente sanos, de uno u otro sexo, de uno a 65 a˜nos, originarios y residentes en Yucatán. Se determinaron los niveles séricos de 25(OH)D, así como los de calcio, fósforo y paratohormona por su relación con el metabolismo de la vitamina D. Los intervalos de referencia se calcularon con los métodos paramétrico y consistente. Se registró el fototipo de piel y se aplicó el test de Garabédian para determinar el consumo diario de calcio y vitamina D. Resultados: El valor medio de 25(OH)D fue de 23,49 ± 5,60 ng/mL. Los límites de referencia para 25(OH)D total y por sexos fueron más estrechos y significativamente diferentes a los propuestos por el fabricante. Se encontró correlación directa entre los niveles de 25(OH)D y el calcio sérico (r=0,36; p=0,003) e inversa con la paratohormona intacta (r=−0,44; p<0,001). Una dieta rica en calcio y vitamina D no es suficiente para mantener los requerimientos normales de 25(OH)D en esta población. Conclusiones: Los intervalos de referencia propuestos están adecuados a las peculiaridades de la población de Yucatán, y pudieran mejorar la exactitud de la medición del estado de salud con base en los niveles séricos de vitamina D.
Additional file 1 of The effects of human pregnancy-specific β1-glycoprotein preparation on Th17 polarization of CD4+ cells and their cytokine profile
Creators: name: Timganova, Valeria P.
name: Zamorina, Svetlana A.
name: Litvinova, Larisa S.
name: Todosenko, Natalia M.
name: Bochkova, Maria S.
name: Khramtsov, Pavel V.
name: Rayev, Mikhail B.
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Table S1. The effect of Th17 polarization on the RORγτ and Ki-67 expression in CD4+ T cells. Medians and interquartile ranges of cell percentages from all alive CD4+ T-cells are presented (Me (Q1–Q3)). Control – CD4 + cell culture with CM only, * - Significant differences (P
Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium
Creators: name: A. Piechulek
name: L. Berwanger
name: A. Von Mikecz
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Despite of the increasing application of silica nanoparticles and identification of oral exposure as a major entry portal we lack understanding of nano silica effects in the gut. Thus, we investigated bio-interactions of nano silica with single intestinal cells. The invertebrate nematode C. elegans was chosen as model organism with a tractable intestine and realistic target organism of nanomaterials in the environment. We found that nano silica impairs the intestinal uptake of oligopeptides. Downstream to absorption by the apical OPT-2/PEP-2 transporter dipeptides were trapped in aberrant vesicles that grow over time and reach diameters of ≥6 micrometers. The peptide vesicles do not correspond to known organelles such as gut granules and form independently of related gene products Glo-1 or Glo-3. Formation of aberrant peptide vesicles also occurred independently of insulin/IGF-I receptor (DAF-2) signaling and daf-2 loss of function mutants showed specific vesicle patterns including distinct localization along the apical membrane of single intestinal cells. Since malnutrition of exposed C. elegans manifested in reduced growth and a petite phenotype similar to OPT-2/PEP-2 transporter deficient mutants, we conclude that nano silica-induced peptide vesicles represent a new compartment of di- and tripeptide trapping which disrupts hydrolysis of nutrient peptides and metabolism.
Nonlocality of the Aharonov-Bohm Effect
Creators: name: Aharonov, Yakir
name: Cohen, Eliahu
name: Rohrlich, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Although the Aharonov-Bohm and related effects are familiar in solid state and high energy physics, the nonlocality of these effects has been questioned. Here we show, for the first time, that the Aharonov-Bohm effect has two very different aspects. One aspect is instantaneous and nonlocal; the other aspect, which depends on entanglement, unfolds continuously over time. While local, gauge-invariant variables may occasionally suffice for explaining the continuous aspect, we argue that they cannot explain the instantaneous aspect. Thus the Aharonov-Bohm effect is, in general, nonlocal.
description: 12 pages, 2 figures
Profiles of appraisal, motivation, and coping for positive emotions
Creators: name: Yih, Jennifer
name: Kirby, Leslie D.
name: Smith, Craig A.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: We used a retrospective survey (N = 346) to model the patterns of appraisal, motivation, and coping that uniquely correspond with 12 positive emotions (affection/love, amusement, awe, challenge/determination, compassion, gratitude, happiness/joy, hope, interest, pride, relief, and serenity/tranquillity). Generally, we conceptually replicated previously demonstrated appraisal profiles of positive emotion while also examining how additional appraisals differentiate among positive emotions. We then uncovered the motivational goals and coping processes associated with each positive emotion. We discuss the implications of our findings for future research on positive emotion.
title: Time-like reductions of supergravity and black string solutions
Creators: name: Dempster, Paul
Publisher: name: University of Liverpool Repository
Year: 2015

description: We consider various geometrical and physical aspects of the supergravity $q$-maps, which are induced by dimensional reduction to three dimensions of five-dimensional $\mathcal{N}=2$ supergravity theories coupled to vector multiplets. In this way, the $q$-maps can be thought of as a composition of the $r$-maps and $c$-maps. We treat in parallel the case of reduction over two space-like directions and over one space-like and one time-like direction. We observe that in the latter case, surprisingly, the order in which the time-like and space-like reductions are performed is relevant for some geometrical properties of the resulting reduced theories. For the simplest example of pure supergravity in five dimensions, we show indeed that the target manifolds obtained from the two reductions correspond to inequivalent open submanifolds in the pseudo-Riemannian symmetric space $G_{2(2)}/(SL_2\cdot SL_2)$. Moreover, each submanifold is endowed with a different integrable structure which makes one a complex manifold and the other a para-complex manifold. As an application we investigate how the $q$-map can be used to generate new non-extremal and extremal non-BPS static black string solutions in five dimensions. We also make progress towards constructing new stationary solutions. The generic nature of these constructions, which don't rely on the target manifolds being symmetric spaces, allow us to gain a more systematic understanding of various properties of black objects in supergravity.
Does money matter? An examination of government funding, school sectors, and student achievement
Creators: name: Ashton, Luke
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The achievement gap between advantaged and disadvantaged students in Australia is one of the largest in the OECD. Due to the litany of negative consequences arising from educational inequality, research has begun to look for policy interventions to improve the educational outcomes of disadvantaged students. A growing body of evidence suggests that modifying school funding policies to better assist disadvantaged students may be one potential solution. This research aims to provide the first systematic analysis of the impact of school funding upon student achievement in Australia. It proposes that government funding has a significant positive effect upon student achievement across all school sectors. Additionally, it proposes that funding has a differential effect upon student achievement based upon school sector and student year-level. The data used in this research was collected by the Australian Curriculum, Assessment and Reporting Authority (ACARA) from 2009-2016, and details school-level financial records and student achievement results for every primary school in Australia. This research finds that government funding has a significant positive impact upon student achievement in Australia in Years 3 and 5. It also finds that independent schools derive a greater increase in student achievement for every dollar spent than schools in the catholic or government sectors, and that government funding has a greater positive effect upon students in Year 3 than in Year 5. Analysis of funding trends also demonstrates that government funding to the independent and catholic sectors has risen substantially faster than government funding to the government sector. Given the lower achievement of the government sector and the reduced impact of every dollar of funding it receives compared to the independent sector, this research concludes that current government funding policies are exacerbating the achievement gap and reinforcing educational inequality in Australia. To reduce the achievement gap in Australia, funding should be redirected from the independent sector to the government sector.
New constraints on $f(R)$ gravity from clusters of galaxies
Creators: name: Cataneo, Matteo
name: Rapetti, David
name: Schmidt, Fabian
name: Mantz, Adam B.
name: Allen, Steven W.
name: Applegate, Douglas E.
name: Kelly, Patrick L.
name: von der Linden, Anja
name: Morris, R. Glenn
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The abundance of massive galaxy clusters is a powerful probe of departures from General Relativity (GR) on cosmic scales. Despite current stringent constraints placed by stellar and galactic tests, on larger scales alternative theories of gravity such as $f(R)$ can still work as effective theories. Here we present constraints on two popular models of $f(R)$, Hu-Sawicki and "designer", derived from a fully self-consistent analysis of current samples of X-ray selected clusters and accounting for all the covariances between cosmological and astrophysical parameters. Using cluster number counts in combination with recent data from the cosmic microwave background (CMB) and the CMB lensing potential generated by large scale structures, as well as with other cosmological constraints on the background expansion history and its mean matter density, we obtain the upper bounds $\log_{10}|f_{R0}| < 4.79$ and $\log_{10}B_0 < 3.75$ at the 95.4 per cent confidence level, for the Hu-Sawicki (with $n=1$) and designer models, respectively. The robustness of our results derives from high quality cluster growth data for the most massive clusters known out to redshifts $z \sim 0.5$, a tight control of systematic uncertainties including an accurate and precise mass calibration from weak gravitational lensing data, and the use of the full shape of the halo mass function over the mass range of our data.
description: 11 pages, 1 Table, 3 figures, matches published version on PRD
Difelikefalin in pruritus associated with chronic kidney disease: a profile of its use
Creators: name: Lamb, Yvette
Publisher: name: Adis Journals
Year: 2022
Subjects: Medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Y. N. Lamb is a salaried employee of Adis International Ltd/Springer Nature and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate and consent for publication, Availability of data and material, Code availability Not applicable. Additional information about this Adis Drug Review can be found here Abstract Difelikefalin (Kapruvia®; Korsuva™), a novel peripheral kappa opioid receptor (KOR) agonist, is a promising emerging treatment for moderate-to-severe pruritus associated with chronic kidney disease (CKD) in adults undergoing haemodialysis. Evidence thus far indicates that difelikefalin is effective and generally well tolerated in these patients. In randomized, double-blind, placebo-controlled, multicentre phase 3 trials, difelikefalin produced clinically meaningful improvements in the intensity of itch in patients with moderate-to-severe CKD-associated pruritus. Difelikefalin was also associated with improved itch-related quality of life relative to placebo. Limited data suggest that clinical benefits are maintained over longer-term treatment. The most common treatment-emergent adverse events in difelikefalin recipients are diarrhoea, dizziness and nausea, typically of mild or moderate severity. © Springer Nature Switzerland AG 2022
Additional file 2 of The effects of human pregnancy-specific β1-glycoprotein preparation on Th17 polarization of CD4+ cells and their cytokine profile
Creators: name: Timganova, Valeria P.
name: Zamorina, Svetlana A.
name: Litvinova, Larisa S.
name: Todosenko, Natalia M.
name: Bochkova, Maria S.
name: Khramtsov, Pavel V.
name: Rayev, Mikhail B.
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Fig. S1. Cytokine profile of Th17-polarized CD4+ cell culture. Medians of cytokine concentrations in control CD4+ culture (with TCR-activator, IL-1β, and IL-6) are presented; n = 11. The box shows the interquartile range (Q1-Q3), the band inside the box is the median (Me), and the ends of the whiskers represent the minimum and maximum of all the data.
AUM302, a novel triple kinase PIM/PI3K/ mTOR inhibitor, is a potent in vitro pancreatic cancer growth inhibitor
Creators: name: LaComb J.F.
name: Ingle K.
name: Graves L.M.
name: Baines A.T.
name: Bialkowska A.B.
Publisher: name: Public Library of Science
Year: 2023

description: Pancreatic cancer is one of the leading causes of cancer deaths, with pancreatic ductal adenocarcinoma (PDAC) being the most common subtype. Advanced stage diagnosis of PDAC is common, causing limited treatment opportunities. Gemcitabine is a frequently used chemotherapeutic agent which can be used as a monotherapy or in combination. However, tumors often develop resistance to gemcitabine. Previous studies show that the proto-oncogene PIM kinases (PIM1 and PIM3) are upregulated in PDAC compared to matched normal tissue and are related to chemoresistance and PDAC cell growth. The PIM kinases are also involved in the PI3K/AKT/mTOR pathway to promote cell survival. In this study, we evaluate the effect of the novel multikinase PIM/PI3K/mTOR inhibitor, AUM302, and commercially available PIM inhibitor, TP-3654. Using five human PDAC cell lines, we found AUM302 to be a potent inhibitor of cell proliferation, cell viability, cell cycle progression, and phosphoprotein expression, while TP-3654 was less effective. Significantly, AUM302 had a strong impact on the viability of gemcitabine-resistant PDAC cells. Taken together, these results demonstrate that AUM302 exhibits antitumor activity in human PDAC cells and thus has the potential to be an effective drug for PDAC therapy.
"My Way or the Highway": Construct Definition, Measure Development and Validation of the Micromanagement Scale
Creators: name: Deen, Catherine
Publisher: name: The Australian National University
Year: 2022

description: Micromanagement is a popular topic in management circles, where its negative reputation is palpable. Surprisingly, academics have not shared this interest, resulting in a deficient understanding of micromanagement, marred by disjointed definitions and paradoxical views. This dissertation research programme contributes to organisational behaviour literature by clarifying the construct and measure of micromanagement through a series of five converging studies aimed at addressing the following goals: (1) clarifying the construct of micromanagement, (2) developing a psychometrically reliable and valid measure for micromanagement and (3) verifying a preliminary nomological network of the antecedents and consequences of micromanagement. The studies spanned three phases: Phase 1 construct definition (Study 1), Phase 2 scale development (Studies 2 and 3), and Phase 3 construct validation (Studies 4 and 5). Through its theoretical, empirical, and practical contributions, this dissertation programme lays the foundation and paves the way for future scholarship on micromanagement in the context of work.
Glyphidocera corniculae ADAMSKI, 2005, new species
Creators: name: DAVID ADAMSKI
Publisher: name: Zenodo
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Symmocidae
Glyphidocera
Glyphidocera corniculae

description: Glyphidocera corniculae, new species (Figs. 36–38, 299, Map 7) Diagnosis.— Glyphidocera corniculae is most similar to G. t e r r a e but differs by having a digitate process of valva that is apically dilated, an apical furca of valval costa that is shorter and more acutely upturned, and a larger apical cornutus of the aedeagal vesica. Description.— Head: Vertex and frontoclypeus brownish orange; labial palpus with outer margin brownish orange intermixed with few dark­brown scales, inner surface pale brownish orange intermixed with few brownish­orange scales; scape of antenna brownish orange, flagellomeres pale brownish orange; male 4 th flagellomere dorsally protuberant and curved, forming a deep concavity opposite slightly excavated flagellomeres 5–6 [setiform scales on apex of protuberance of 4 th flagellomere missing]; proboscis pale brownish orange. Thorax: Tegula and mesonotum brownish orange. Legs pale brownish orange. Forewing (Fig. 299): Length 9.1 mm (n = 1), brownish orange with a brown spot near distal end of cell. Undersurface brownish orange. Hindwing: Brownish orange. Abdomen (Fig. 36): Male with 4 transverse, irregular rows of sex scales on intersegmental area between terga 2–3. Male Genitalia (Figs. 37–38): Uncus elongate, wide at base, parallelsided to midlength, gradually narrowing to an acuminate and setose apex; gnathos sparsely setose, protuberant, wide throughout length, upturned apically; tegumen slightly widened basally; dorsal strut of tegumen absent; costa of valva gradually sloped to an abruptly upturned apical furca; furca with slightly serrate outer margin; base of costa with a digitate process with a knoblike apical process; sacculus twisted apically, constricting valva slightly before midlength, widening distoventrally, forming an elongate and broadly rounded cucullus; cucullus membranous and setose; vesica of aedeagus denticulate, bearing a broad and elongate apical cornutus; cornutus with a slightly shortened side, exposing a hollow, basal cavity. Female Genitalia: Unknown. Holotype, ɗ, “Est[ación] La Carsona, 1520 m, Res[erva] Biol[ógica] Monteverde, Prov[incia] Puntarenas, COSTA RICA, N. Obando, Ene. 1992, L­N­ 253250, 449700 ”, INBio: COSTA RICA: CRI 000, 922216 ” [bar code label], “ INBio, ɗ Genitalia Slide by D. Adamski, No. 830 ” [yellow label]. Distribution (Map 7): Glyphidocera corniculae is known from one collecting site in the cloud forests of Monteverde in west­central Costa Rica along the southern part of the Cordillera de Tilarán. Etymology: The species name corniculae is from the Latin “cornicula” meaning a little cow.
description: Published as part of DAVID ADAMSKI, 2005, Review of Glyphidocera Walsingham of Costa Rica (Lepidoptera: Gelechioidea: Glyphidoceridae), pp. 1-158 in Zootaxa 858 on pages 30-32, DOI: 10.5281/zenodo.170793
Magma evolution and fertility of the supergiant porphyry Cu deposits from Central Chile: insights from PGE and zircon geochemistry
Creators: name: Cajal Contreras, Yamila
Publisher: name: The Australian National University
Year: 2023

description: Copper is used in every aspect of our society and its demand is increasing due to its critical role in the transition from fossil fuel to green energy. Porphyry copper deposits, which are the world's primary source of this metal, have been widely studied; however, it is still unclear why some porphyry systems are fertile (capable of producing ore deposits) while others are not. This work explores this question by studying igneous rocks associated with the world's largest and third-largest Cu deposits, the Rio Blanco and El Teniente deposits in Central Chile, with special emphasis on the role that sulphide saturation plays in determining magma fertility. New whole-rock, major and trace element data, including platinum group elements (PGE), as well as zircon O-Hf isotopes, trace elements and U-Pb ages from intrusions related to these deposits, are presented. The results show that the magmas that produced the regional and ore-related intrusions are co-magmatic, and that the magmatism was continuous for at least 4 Myr. The magmas that gave rise to these intrusions came from a mantle wedge modified by melts derived from greywackes at the top of the underlying subducted slab. The results show that the magmatic evolution was controlled by amphibole fractionation, with garnet playing a minor role, suggesting that the magma was water-rich and that it fractionated in a chamber located in the upper half of the lower crust. The PGE geochemistry shows that the Rio Blanco and Teniente magmatic systems reached sulphide saturation early in their evolution, in the deep, unexposed magma chamber. This depleted the magma in Au relative to Cu, leading to the formation of Cu-dominated deposits. Calculations of Ce4+/Ce3+, Eu/Eu* and delta FMQ values for the different intrusive units suggest that the fO2 and water content of the magma increased towards the later stages of the magmatic evolution. The increase in water content is attributed to extensive fractional crystallization and the increase in fO2 to the crystallization of olivine, pyroxene and, to a lesser extent, amphibole. It is concluded that the timing of sulphide saturation did not play a key role in the formation of these deposits because an early sulphide saturation did not prevent the formation of two of the world's largest copper deposits. Instead, it is argued that other factors such as the small amount of sulphide melt to precipitate from the magma, and the enormous size of the deep magma chamber, were responsible for the formation of these supergiant deposits.
A note on statistical properties for nonuniformly hyperbolic systems with slow contraction and expansion
Creators: name: Melbourne, Ian
name: Varandas, Paulo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37D25 (Primary), 37D50, 37A50, 60F17 (Secondary)

description: We provide a systematic approach for deducing statistical limit laws via martingale-coboundary decomposition, for nonuniformly hyperbolic systems with slowly contracting and expanding directions. In particular, if the associated return time function is square-integrable, then we obtain the central limit theorem, the weak invariance principle, and an iterated version of the weak invariance principle.
description: Final version
Additional file 10 of Electroencephalographic features in patients undergoing extracorporeal membrane oxygenation
Creators: name: Peluso, Lorenzo
name: Rechichi, Serena
name: Franchi, Federico
name: Pozzebon, Selene
name: Scolletta, Sabino
name: Brasseur, Alexandre
name: Legros, Benjamin
name: Jean-Louis Vincent
name: Creteur, Jacques
name: Gaspard, Nicolas
name: Taccone, Fabio Silvio
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 10 Description of a case of early diagnose of stroke.
title: Evaluation von Random Forest und Oblique Forest für einen Vergleich in Bezug auf ihre Performance
Creators: name: Dubberstein, Dario
Publisher: name: Friedrich-Schiller-Universität Jena
Year: 2021
Subjects: subject: Data Mining
subject: Random Forest
subject: Oblique Random Forest
subject: 330

description: Mit dem aktuell steigendem Internetverkehr und der damit einhergehenden Speicherung und Verarbeitung von Daten, wird dem Data Mining mehr an Bedeutung zugeordnet. Unternehmen setzen vermehrt auf Prognoseverfahren, um Sicherheitsrisiken zu identifizieren oder kaufverhalten vorherzusagen. Durch dieses steigende Interesse gilt es zunehmen die Forschung an aktuellen und die Analyse vorhandener Klassifikationsverfahren voran-zutreiben. In seiner ursprünglichen Arbeit über Random Forests schlug Breiman zwei verschiedene Entscheidungsbaum-Ensembles vor. Eines aus orthogonalen Bäumen mit Schwellenwerten für einzelne Features in jedem Split, und eines aus schrägen Bäumen, die den Feature-Raum durch zufällig orientierte Hyperebenen trennen. Die vorliegende Arbeit untersucht jeweils ein Verfahren mit diesen Eigenschaften, namentlich Random Forest und Oblique Forest, auf ihre Performance. Unter Verwendung von Standardparameter überzeugte der Oblique Forest auf einem Großteil der getesteten Datensätze, wobei die Rechenzeit in vielen Fällen, über dem des Random Forest lag. Bei der Erstellung der Klassifikationsmodelle konnte zudem eine größere Varianz der Ergebnisse bei dem Random Forest beobachtet werden. Im Vergleich konnte der Random Forest mit einem deutlich geringeren zeitlichen Aufwand implementiert werden. Zudem stellen aktuelle Bibliotheken für den Random Forest viele Optimierungs-möglichkeiten zu Verfügung, wodurch sich die Genauigkeit mit einem hohen Maß an Rechenzeit zum Teil anpassen lässt.
Additional file 11 of Electroencephalographic features in patients undergoing extracorporeal membrane oxygenation
Creators: name: Peluso, Lorenzo
name: Rechichi, Serena
name: Franchi, Federico
name: Pozzebon, Selene
name: Scolletta, Sabino
name: Brasseur, Alexandre
name: Legros, Benjamin
name: Jean-Louis Vincent
name: Creteur, Jacques
name: Gaspard, Nicolas
name: Taccone, Fabio Silvio
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 11 Description of a case of Nonconvulsive Status Epilepticus treated with success.
CK2 Chemical Probes: Past, Present, and Future
Creators: name: Ong, Han Wee
name: Axtman, Alison D.
name: Drewry, David H.
Publisher: name: MDPI
Year: 2023

description: Protein kinase casein kinase 2 (CK2/CSNK2) is a pleiotropic kinase involved in many cellular processes and, accordingly, has been identified as a potential target for therapeutic intervention for multiple indications. Significant research effort has been invested into identifying CK2 inhibitors as potential drug candidates and potent and selective CK2 chemical probes to interrogate CK2 function. Here, we review the small molecule inhibitors reported for CK2 and discuss various orthosteric, allosteric, and bivalent inhibitors of CK2. We focus on the pyrazolo[1,5-a]pyrimidines and naphthyridines, two chemotypes that have been extensively explored for chemical probe development. We highlight the uptake and demonstrated utility of the pyrazolo[1,5-a]pyrimidine chemical probe SGC-CK2-1 by the scientific community in cellular studies. Finally, we propose criteria for an ideal in vivo chemical probe for investigating CK2 function in a living organism. While no compound currently meets these metrics, we discuss ongoing and future directions in the development of in vivo chemical probes for CK2.
Revisiting Hartle's model using perturbed matching theory to second order: amending the change in mass
Creators: name: Reina, Borja
name: Vera, Raül
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Hartle's model describes the equilibrium configuration of a rotating isolated compact body in perturbation theory up to second order in General Relativity. The interior of the body is a perfect fluid with a barotropic equation of state, no convective motions and rigid rotation. That interior is matched across its surface to an asymptotically flat vacuum exterior. Perturbations are taken to second order around a static and spherically symmetric background configuration. Apart from the explicit assumptions, the perturbed configuration is constructed upon some implicit premises, in particular the continuity of the functions describing the perturbation in terms of some background radial coordinate. In this work we revisit the model within a modern general and consistent theory of perturbative matchings to second order, which is independent of the coordinates and gauges used to describe the two regions to be joined. We explore the matching conditions up to second order in full. The main particular result we present is that the radial function $m_0$ (in the setting of the original work) of the second order perturbation tensor, contrary to the original assumption, presents a jump at the surface of the star, which is proportional to the value of the energy density of the background configuration there. As a consequence, the change in mass needed by the perturbed configuration to keep the value of the central energy density unchanged must be amended. We also discuss some subtleties that arise when studying the deformation of the star.
description: 38 pages, two figures; two paragraphs improved with a clearer statement, typos corrected, added two references, updated one; matches published version
Additional file 5 of Electroencephalographic features in patients undergoing extracorporeal membrane oxygenation
Creators: name: Peluso, Lorenzo
name: Rechichi, Serena
name: Franchi, Federico
name: Pozzebon, Selene
name: Scolletta, Sabino
name: Brasseur, Alexandre
name: Legros, Benjamin
name: Jean-Louis Vincent
name: Creteur, Jacques
name: Gaspard, Nicolas
name: Taccone, Fabio Silvio
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 5 Univariate and multivariate analyses to predict favorable neurological outcome at 3 months, according to EEG reactivity.
Competing risks modeling of length of hospital stay enhances risk-stratification of patient care: application to under-five children hospitalized in Malawi
Creators: name: Zulu, Madalitso
name: Chinkhumba, Jobiba
name: Mvalo, Tisungane
name: Stanley, Christopher C.
name: Phiri, Vincent S.
name: Msuku, Harrison
name: Mathanga, Don P.
name: Kazembe, Lawrence N.
Publisher: name: Frontiers Media SA
Year: 2023

description: Introduction Length of hospital stay (LOS), defined as the time from inpatient admission to discharge, death, referral, or abscondment, is one of the key indicators of quality in patient care. Reduced LOS lowers health care expenditure and minimizes the chance of in-hospital acquired infections. Conventional methods for estimating LOS such as the Kaplan-Meier survival curve and the Cox proportional hazards regression for time to discharge cannot account for competing risks such as death, referral, and abscondment. This study applied competing risk methods to investigate factors important for risk-stratifying patients based on LOS in order to enhance patient care. Methods This study analyzed data from ongoing safety surveillance of the malaria vaccine implementation program in Malawi's four district hospitals of Balaka, Machinga, Mchinji, and Ntchisi. Children aged 1–59 months who were hospitalized (spending at least one night in hospital) with a medical illness were consecutively enrolled between 1 November 2019 and 31 July 2021. Sub-distribution-hazard (SDH) ratios for the cumulative incidence of discharge were estimated using the Fine-Gray competing risk model. Results Among the 15,463 children hospitalized, 8,607 (55.7%) were male and 6,856 (44.3%) were female. The median age was 22 months [interquartile range (IQR): 12–33 months]. The cumulative incidence of discharge was 40% lower among HIV-positive children compared to HIV-negative (sub-distribution-hazard ratio [SDHR]: 0.60; [95% CI: 0.46–0.76]; P < 0.001); lower among children with severe and cerebral malaria [SDHR: 0.94; (95% CI: 0.86–0.97); P = 0.04], sepsis or septicemia [SDHR: 0.90; (95% CI: 0.82–0.98); P = 0.027], severe anemia related to malaria [SDHR: 0.54; (95% CI: 0.48–0.61); P < 0.001], and meningitis [SDHR: 0.18; (95% CI: 0.09–0.37); P < 0.001] when compared to non-severe malaria; and also 39% lower among malnourished children compared to those that were well-nourished [SDHR: 0.61; (95% CI: 0.55–0.68); P < 0.001]. Conclusions This study applied the Fine-Gray competing risk approach to more accurately model LOS as the time to discharge when there were significant rates of in-hospital mortality, referrals, and abscondment. Patient care can be enhanced by risk-stratifying by LOS based on children's age, HIV status, diagnosis, and nutritional status.