cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stripe-like nanoscale structural phase separation and optimal inhomogeneity in superconducting BaPb$_{1-x}$Bi$_x$O$_3$
Creators: name: Giraldo-Gallo, P.
name: Zhang, Y.
name: Parra, C.
name: Manoharan, H. C.
name: Beasley, M. R.
name: Geballe, T. H.
name: Kramer, M. J.
name: Fisher, I. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Structural phase separation in the form of partially disordered stripes, with characteristic length scales in the nanometer range, is observed for superconducting BaPb$_{1-x}$Bi$_x$O$_3$. The evolution of the superconducting coherence length with composition relative to the size of these stripes suggests an important role of the nanostructure in determining the shape of the superconducting dome. It is proposed that the maximum $T_c$ is determined by a kind of "optimal inhomogeneity", characterized by a crossover from an inhomogeneous macroscopic superconductor to a granular superconductor for which phase fluctuations suppress $T_c$.
Orbital Nematic Order and Interplay with Magnetism in the Two-Orbital Hubbard Model
Creators: name: Wang, Zhentao
name: Nevidomskyy, Andriy H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Motivated by the recent angle-resolved photoemission spectroscopy (ARPES) on FeSe and iron pnictide families of iron-based superconductors, we have studied the orbital nematic order and its interplay with antiferromagnetism within the two-orbital Hubbard model. We used random phase approximation (RPA) to calculate the dependence of the orbital and magnetic susceptibilities on the strength of interactions and electron density (doping). To account for strong electron correlations not captured by RPA, we further employed non-perturbative variational cluster approximation (VCA) capable of capturing symmetry broken magnetic and orbitally ordered phases. Both approaches show that the electron and hole doping affect the two orders differently. While hole doping tends to suppress both magnetism and orbital ordering, the electron doping suppresses magnetism faster. Crucially, we find a realistic parameter regime for moderate electron doping that stabilizes orbital nematicity in the absence of long-range antiferromagnetic order. This is reminiscent of the non-magnetic orbital nematic phase observed recently in FeSe and a number of iron pnictide materials and raises the possibility that at least in some cases, the observed electronic nematicity may be primarily due to orbital rather than magnetic fluctuations.
description: 11 pages, 11 figures
Protein-protein interaction and novel biomarkers of bladder cancer
Creators: name: Iftikhar, Rehana
name: Silverman, Rosalind
name: Silverman, Lorelei
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 321101
subject: Cancer cell biology
classificationCode: 321102
subject: Cancer diagnosis
classificationCode: 321103
subject: Cancer genetics
classificationCode: 321108
subject: Molecular targets
classificationCode: 321109
subject: Predictive and prognostic markers
classificationCode: 321111
subject: Solid tumours
classificationCode: 321199
subject: Oncology and carcinogenesis not elsewhere classified

description: Bladder cancer is the 10th most common cancer in the world [1]. It is the 6th most common amongst men and the 17th most common amongst women, making men 4 times more likely to develop it [1]. Unfortunately, those who develop it once are at a high risk of the cancer reoccurring and thus need regular monitoring done by a specialist every 3-6 months [2]. Not only is it a challenging and expensive cancer to diagnose because it relies mainly on cystoscopy, an invasive and expensive procedure, but also to treat [3]. Through this research, we aim to use proteomics in an attempt to discover links between proteins that could be connected to bladder cancer, which may provide a better understanding of the disease. We were able to find 40 genes using PubMed that are connected to bladder cancer, which have been studied as potential biomarkers. Employing genomics, proteomics and bioinformatics tools such as PANTHER, STRING and Human Protein Atlas, protein-protein interactions were further analyzed and potential novel biomarkers were identified. Further studies of these proteins and their pathways may prove to play a vital role in the diagnosis, prognosis, treatment and better overall understanding of this disease.
A Genetic Programming Encoder for Increasing Autoencoder Interpretability
Creators: name: Schofield, Finn
name: Slyfield, Luis
name: Lensen, Andrew
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: Autoencoders are powerful models for non-linear dimensionality reduction. However, their neural network structure makes it difficult to interpret how the high dimensional features relate to the lowdimensional embedding, which is an issue in applications where explainability is important. There have been attempts to replace both the neural network components in autoencoders with interpretable genetic programming (GP) models. However, for the purposes of interpretable dimensionality reduction, we observe that replacing only the encoder with GP is sufficient. In this work, we propose the Genetic Programming Encoder for Autoencoding (GPE-AE). GPE-AE uses a multi-tree GP individual as an encoder, while retaining the neural network decoder. We demonstrate that GPE-AE is a competitive non-linear dimensionality reduction technique compared to conventional autoencoders and a GP based method that does not use an autoencoder structure. As visualisation is a common goal for dimensionality reduction, we also evaluate the quality of visualisations produced by our method, and highlight the value of functional mappings by demonstrating insights that can be gained from interpreting the GP encoders.
Uncompensated polyuria in a mouse model of Bartter's syndrome
Creators: name: Igarashi, P.
name: Gomez, R. A.
name: Smithies, O.
name: Gitelman, H. J.
name: Takahashi, N.
name: Chernavvsky, D. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: We have used homologous recombination to disrupt the mouse gene coding for the NaK2Cl cotransporter (NKCC2) expressed in kidney epithelial cells of the thick ascending limb and macula densa. This gene is one of several that when mutated causes Bartter's syndrome in humans, a syndrome characterized by severe polyuria and electrolyte imbalance. Homozygous NKCC2−/− pups were born in expected numbers and appeared normal. However, by day 1 they showed signs of extracellular volume depletion (hematocrit 51%; wild type 37%). They subsequently failed to thrive. By day 7, they were small and markedly dehydrated and exhibited renal insufficiency, high plasma potassium, metabolic acidosis, hydronephrosis of varying severity, and high plasma renin concentrations. None survived to weaning. Treatment of −/− pups with indomethacin from day 1 prevented growth retardation and 10% treated for 3 weeks survived, although as adults they exhibited severe polyuria (10 ml/day), extreme hydronephrosis, low plasma potassium, high blood pH, hypercalciuria, and proteinuria. Wild-type mice treated with furosemide, an inhibitor of NaK2Cl cotransporters, have a phenotype similar to the indomethacin-rescued −/− adults except that hydronephrosis was mild. The polyuria, hypercalciuria, and proteinuria of the −/− adults and furosemide-treated wild-type mice were unresponsive to inhibitors of the renin angiotensin system, vasopressin, and further indomethacin. Thus absence of NKCC2 in the mouse causes polyuria that is not compensated elsewhere in the nephron. The NKCC2 mutant animals should be valuable for uncovering new pathophysiologic and therapeutic aspects of genetic disturbances in water and electrolyte recovery by the kidney.
title: The 14th Kilbrandon Lecture (University of Strathclyde, 23 November 2016) : 'Every man, every woman, every child should have a basic income as a right'
Creators: name: Standing, Guy
Publisher: name: Strathprints - University of Strathclyde
Year: 2017

description: On page 1 of my book The Precariat: The New Dangerous Class, published in 2011, it was stated that unless the insecurities and needs and aspirations of the precariat were addressed as a matter of urgency, a political monster would emerge. Following the election of Donald Trump in November, a number of readers have written to say the monster has arrived. Unfortunately for us, he is not going to be the only political monster. We have the prospect of Marine Le Pen. We have disgusting people running Turkey and Hungary, and we have our own types in the wings, waiting to take over. We are on red. Not amber. We are on red.
How the psychological effects of the Black Death may foreshadow our futures living with COVID-19
Creators: name: Smith, Auralee
Publisher: name: No Publisher Supplied
Year: 2022

description: When looking at history through a wide lens, acknowledging pandemics as frequent and unavoidable is not difficult to do. Since the origin of organic life, disease has been a prominent feature. Therefore, it is also not much trouble to imagine that humanity will experience additional pandemics in the future. Knowing this, it is clearly important to investigate past pandemics and modern pandemics in order to garner information that will affect our response to future pandemics: medically, legislatively, socially, physically, emotionally, and psychologically. Conveniently, investigating the psychological effects of past and modern pandemics can lead to information on how to cope with future pandemics in all other potential areas of life as well. Psychology dictates the majority of what non-sentient aspects of life cannot, and therefore deserves to be delved into. Through my research, I studied and compared how those living during both the Black Death Pandemic and the COVID-19 Pandemic handled subjects such as quarantines, religious influences, prejudice, scapegoating, economic changes, governmental decisions, and much more. I discovered that 14th century Europeans had much more in common with 21st century Americans and Europeans than one might originally think. For example, both groups of people found quarantine policies and enforcements to have an incredible psychological weight to them. The strain of isolation and changes in daily routine weighed on everyone involved. Another example of similarity between time periods can be seen in terms of workers’ rights movements. The Black Death Pandemic led to an end of serfdom and feudalism just as the COVID-19 Pandemic led to immense demand from employees for higher wages and increased respect. One similarity between the effects of both pandemics that desperately requires changing, however, is preparation for the future. 14th century Europe did little to nothing to truly prepare themselves for the inevitable next pandemic to come, just as the modern United States has done. Most importantly, in order to prepare for our next pandemic we need to increase public knowledge of how mass disease works, and how they can influence the future as to avoid issues society encountered with COVID-19, such as understaffing nearly everywhere, a lack of adequate medical equipment, distrust in leaders and policies, and an ignorance about what a pandemic really entails in all aspects of life.
The Welfare Impacts of the Egg Pesticide Contamination Incident in Korea
Creators: name: Cho, Hyunkyoung
name: Cho, Hyunkyoung
Publisher: name: Unknown
Year: 2019
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: fipronil eggs
subject: food safety
subject: consumer welfare

description: This study analyzes the impact of the 2017 egg contamination incident in South Korea on consumers’ welfare. We estimate two types of single equation demand systems for eggs, and those equations incorporate consumers' subjective perception of eggs’ quality. The estimation is based on a survey on agri-food expenditure designed and implemented by the Rural Development Administration, and the aggregated household data from the survey are used to represent national price and consumption of eggs as well as agri-food expenditure. Our results show that the total consumer welfare loss was 811.8~854.9 billion won, and the cost caused by ignorance about the incident accounted for 12.0~12.9% (102.7~104.9 billion won) of the total loss. These results suggest that dissemination of accurate information and prompt action after a contamination incident along with efforts to secure safety of goods' quality are important in order to alleviate consumers' welfare loss.
Von der Enttäuschung der Unmittelbarkeit zur von Hoffnung genährten Utopie
Creators: name: Casaldáliga, Pedro
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 41 Nr. 3 (2005): Concilium: Internationale Zeitschrift für Theologie, Band 41, Heft 3
The evolution of the mantle source beneath Mt. Etna (Sicily, Italy): from the 600 ka tholeiites to the recent trachybasaltic magmas
Creators: name: Casetta, Federico
name: Giacomoni, Pier Paolo
name: Ferlito, Carmelo
name: Bonadiman, Costanza
name: Coltorti, Massimo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The spatial/temporal proximity of Mt. Etna to the Hyblean Plateau and the Aeolian slab makes the discussion on the nature of its mantle source/s extremely controversial. In this study, a detailed geochemical overview of the entire Mt. Etna evolutionary sequence and a comparison with the magmatism of the Hyblean Plateau was proposed to: (i) simulate the composition of Mt. Etna tholeiitic to alkaline primitive magmas in equilibrium with a fertile mantle source; (ii) model the nature, composition and evolution of the mantle source from the tholeiitic stage (600 ka) to present magmatism. According to our simulations, two amphibole + phlogopite-bearing spinel lherzolite sources are able to explain the wide range of Etnean primary magmas. The enrichment in LILE, 87Sr/86Sr, Rb and H2O of the magmas emitted after 1971 (but also discontinuously generated in both historic and prehistoric times) are caused by different melting proportions of amphibole and phlogopite in a modally and compositionally homogeneous mantle domain, with melting degrees analogous to those required to produce magmas erupted prior to 1971. The behaviour of the hydrous phases during melting could be ascribed to a variable H2O/CO2 activity in the mantle source, in turn related to the heat/fluxes supply from the asthenospheric upwelling beneath Mt. Etna. All these considerations, strengthened by numerical models, are then merged to review the complex Pliocene/Lower Pleistocene to present day’s geodynamic evolution of eastern Sicily.
The YNEV stellar evolution and oscillation code
Creators: name: Zhang, Q. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have developed a new stellar evolution and oscillation code YNEV, which calculates the structures and evolutions of stars, taking into account hydrogen and helium burning. A nonlocal turbulent convection theory and an updated overshoot mixing model are optional in this code. The YNEV code can evolve low- and intermediate-mass stars from pre-main sequence (PMS) to thermal pulsing asymptotic branch giant (TP-AGB) or white dwarf. The YNEV oscillation code calculates the eigenfrequencies and eigenfunctions of the adiabatic oscillations of given stellar structure. The input physics and the numerical scheme adopted in the code are introduced in this paper. The examples of solar models, stellar evolutionary tracks of low- and intermediate-mass stars with different convection theory (i.e., mixing-length theory (MLT) and the nonlocal turbulent convection theory), and stellar oscillations are shown.
description: 18 pages, 14 figures, accepted for publication in the Research in Astronomy and Astrophysics (RAA)
A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics
Creators: name: Resch, W.
name: Watkins, T.
name: Swanstrom, R.
name: Stuelke, E. L.
name: Parkin, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Rapidly evolving entities, such as viruses, can undergo complex genetic changes in the face of strong selective pressure. We have developed a modified heteroduplex tracking assay (HTA) capable of detecting the presence of single, specific mutations or sets of linked mutations. The initial application of this approach, termed multiple-site-specific (MSS) HTA, was directed toward the detection of mutations in the HIV-1 pro gene at positions 46, 48, 54, 82, 84, and 90, which are associated with resistance to multiple protease inhibitors. We demonstrate that MSS HTA is sensitive and largely specific to all targeted mutations. The assay allows the accurate and reproducible quantitation of viral subpopulations comprising 3% or more of the total population. Furthermore, we used MSS HTA in longitudinal studies of pro gene evolution in vitro and in vivo. In the examples shown here, populations turned over rapidly and more than one population was present frequently. To demonstrate the versatility of MSS HTA, we also constructed a probe sensitive to changes at positions 181 and 184 of the RT coding domain. Changes at these positions are involved in resistance to nevirapine and 2′,3′-dideoxy-3′-thiacytidine (3TC), respectively. This assay easily detected the evolution of resistance to 3TC. MSS HTA provides a rapid and sensitive approach for detecting the presence of and quantifying complex mixtures of distinct genotypes, including genetically linked mutations, and, as one example, represents a useful tool for following the evolution of drug resistance during failure of HIV-1 antiviral therapy.
Ermutigt von den Gerüchten eines zarten Schweigens
Creators: name: Vitoria Cormenzana, F. Javier
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 41 Nr. 3 (2005): Concilium: Internationale Zeitschrift für Theologie, Band 41, Heft 3
Thermochronology and exhumation rates of granitic intrusions at Mesa Central, Mexico
Creators: name: Nieto-Samaniego, Angel F.
name: de Jesús Paulina Olmos-Moya, María
name: Levresse, Gilles
name: Alaniz-Alvarez, Susana A.
name: Abdullin, Fanis
name: del Pilar-Martínez, Alexis
name: Xu, Shunshan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mental Health

description: The Mesa Central of Mexico (MC) is an elevated plateau located 2000 m above sea level in central Mexico, where intrusions outcrop that register the history of exhumation-erosion occurring during the Late Cretaceous-Paleogene. The tectonic history of the region records formation of the Late Cretaceous-Paleogene ‘Mexican orogen’; this was followed by extension of the entire region and several plutons were then exhumed. The age and magnitude of the crustal uplift and erosion occurring during exhumation has not been addressed to date. Therefore, this study reports the crystallization and cooling ages of two plutons, the Tesorera Granodiorite and the Comanja Granite, and estimates their emplacement depths. Based on these data, the exhumation age of the Tesorera Granodiorite is estimated to be between ~73 Ma and ~63 Ma at an exhumation rate of ~528 m/m. y. and that of the Comanja Granite is 52 Ma and 48 Ma at an exhumation rate of ~2500 m/m. y. Exhumation-erosion event of the Tesorera Granodiorite was located on the trace of the San Luis-Tepehuanes Fault System and that of the Comanja Granite on the a trace of the El Bajío Fault System. Furthermore, the high exhumation rate in the Comanja Granite suggests that gravitational collapse played an important role during exhumation.
title: IL CONTRATTO. Corso di diritto privato svolto secondo il metodo comparativo e casistico. Volume II
Creators: name: Gorla, Gino
Publisher: name: Roma TrE-Press
Year: 2023

description:

Quando, nel 1954, furono pubblicati i due volumi di Gino Gorla dedicati a “Il Contratto” la dottrina italiana del diritto civile, imbevuta di concettualismo pandettistico, quasi non se ne accorse. D’altronde era difficile che potesse accettare una visione realista e funzionale del diritto che metteva in dubbio le sue certezze e offriva una lettura non dogmatica di un istituto, il contratto, che vive e si sviluppa nel quotidiano agire sociale ed economico. Che, poi, un accademico si cimentasse nella analisi della prosaica giurisprudenza era, se non una eresia, quantomeno una bizzarria. Ben diversa fu l’attenzione – pur ostacolata dalla barriera linguistica – con la quale l’opera fu accolta all’estero, sia per la profondità del pensiero che per il metodo casistico proposto ed applicato alla comparazione giuridica. A distanza di settant’anni  “Il Contratto” di Gorla conserva ancora la freschezza di pensiero non convenzionale e costituisce un punto di riferimento essenziale   per il giurista che voglia studiare l’istituto sia nella dimensione domestica che in quella comparata. E troverà nel secondo volume una messe di casi che tuttora costituiscono validi esempi delle ratio decidendi inespresse sulle quali poggia la giurisprudenza del presente.
Vun Aam vun Driwe! oder: Oerünnerungen eines Sachsenhäusers an die Märzdäg' und das Vorparlement 1848; [1849]
Creators: name: R., J. ¬von
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel
Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat
Creators: name: Samulski, R. J.
name: Young, S. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Adeno-associated virus (AAV) is the only known eukaryotic virus capable of targeted integration in human cells. An AAV Rep binding element (RBE) and terminal resolution site (trs) identical to the viral terminal repeats required for AAV DNA replication are located on chromosome (ch) 19. Both ch-19 RBE and trs elements have been shown to be essential for viral targeting to this locus. To characterize the role of the AAV inverted terminal repeat (ITR) cis-acting sequences in targeted integration an AAV trs mutant incapable of supporting viral replication was tested. Wild-type and mutant substrates were assayed for targeted integration after cotransfection in the presence or absence of Rep. Our results demonstrated that, in the presence of Rep78, both ITR substrates targeted to ch-19 with similar frequency. Molecular characterization of the mutant ITR integrants confirmed the presence of the trs mutation in the majority of samples tested. Complementation analysis confirmed that the mutant targeted viral genomes were unable to rescue and replicate. In addition, Rep78 induced extensive rearrangement and amplification of ch-19 sequences independent of wild-type or mutant targeting substrate. These studies demonstrate that Rep-dependent nicking of the viral cis-acting trs sequence is not a prerequisite for site-specific recombination and suggests AAV targeting is mediated by Rep78/68-dependent replication from the ch-19 origin of replication (ori). These studies have significant impact toward the understanding of AAV site-specific recombination and the development of targeting vectors.
Aplicações Computacionais em Humanidades na Pesquisa de Gestão de Políticas Públicas com Relação a Mobilidade Urbana
Creators: name: , Otavio
Publisher: name: Zenodo
Year: 2021
Subjects: Humanidades Digitais
Mobilidade Urbana
Computação em Políticas Públicas

description: Esta é a apresentação do dia 08 de Outubro de 2021, na XI SEMANA ACADÊMICA - IFRJ – CEPF “A transversalidade da ciência, tecnologia e inovações para o planeta”. Onde apresentarei minha linha de pesquisa no mestrado na UFRRJ em Humanidades Digitais.
description: Minha estrutura de pesquisa usa a mobilidade como pano de fundo para exemplificar desigualdades sociais em diversos âmbitos como: renda, empregabilidade, saúde, educação, cultura e lazer, do ponto de vista comparativo com relação ao acesso através de transportes públicos, a fim de que possam ser criadas ou melhoradas políticas públicas nesse segmento. Minha hipótese é que há uma relação diretamente proporcional entre mobilidade, acesso e melhor desempenho social.
Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
Creators: name: Piesman, J.
name: Ohnishi, J.
name: de Silva, A. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The genome of Borrelia burgdorferi encodes a large number of lipoproteins, many of which are expressed only at certain stages of the spirochete's life cycle. In the current study we describe the B. burgdorferi population structure with respect to the production of two lipoproteins [outer surface protein A (OspA) and outer surface protein C (OspC)] during transmission from the tick vector to the mammalian host. Before the blood meal, the bacteria in the tick were a homogeneous population that mainly produced OspA only. During the blood meal, the population became more heterogeneous; many bacteria produced both OspA and OspC, whereas others produced only a single Osp and a few produced neither Osp. From the heterogeneous spirochetal population in the gut, a subset depleted of OspA entered the salivary glands and stably infected the host at time points >53 hr into the blood meal. We also examined genetic heterogeneity at the B. burgdorferi vlsE locus before and during the blood meal. In unfed ticks, the vlsE locus was stable and one predominant and two minor alleles were detected. During the blood meal, multiple vlsE alleles were observed in the tick. Tick feeding may increase recombination at the vlsE locus or selectively amplify rare vlsE alleles present in unfed ticks. On the basis of our data we propose a model, which is different from the established model for B. burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host.
Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells
Creators: name: Milgram, S. L.
name: Boucher, R. C.
name: Lazarowski, E. R.
name: Huang, P.
name: Tarran, R.
name: Stutts, M. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Physical stimulation of airway surfaces evokes liquid secretion, but the events that mediate this vital protective function are not understood. When cystic fibrosis transmembrane conductance regulator (CFTR) channel activity was used as a functional readout, we found signaling elements compartmentalized at both extracellular and intracellular surfaces of the apical cell membrane that activate apical Cl− conductance in Calu-3 cells. At the outer surface, ATP was released by physical stimuli, locally converted to adenosine, and sensed by A2B adenosine receptors. These receptors couple to G proteins, adenylyl cyclase, and protein kinase A, at the intracellular face of the apical membrane to activate colocalized CFTR. Thus, airways have evolved highly efficient mechanisms to “flush” noxious stimuli from airway surfaces by selective activation of apical membrane signal transduction and effector systems.
Thermochronology and exhumation rates of granitic intrusions at Mesa Central, Mexico
Creators: name: F. Nieto-Samaniego, Angel
name: de Jesús Paulina Olmos-Moya, María
name: Levresse, Gilles
name: Alaniz-Alvarez, Susana A.
name: Abdullin, Fanis
name: del Pilar-Martínez, Alexis
name: Xu, Shunshan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: The Mesa Central of Mexico (MC) is an elevated plateau located 2000 m above sea level in central Mexico, where intrusions outcrop that register the history of exhumation-erosion occurring during the Late Cretaceous-Paleogene. The tectonic history of the region records formation of the Late Cretaceous-Paleogene ‘Mexican orogen’; this was followed by extension of the entire region and several plutons were then exhumed. The age and magnitude of the crustal uplift and erosion occurring during exhumation has not been addressed to date. Therefore, this study reports the crystallization and cooling ages of two plutons, the Tesorera Granodiorite and the Comanja Granite, and estimates their emplacement depths. Based on these data, the exhumation age of the Tesorera Granodiorite is estimated to be between ~73 Ma and ~63 Ma at an exhumation rate of ~528 m/m. y. and that of the Comanja Granite is 52 Ma and 48 Ma at an exhumation rate of ~2500 m/m. y. Exhumation-erosion event of the Tesorera Granodiorite was located on the trace of the San Luis-Tepehuanes Fault System and that of the Comanja Granite on the a trace of the El Bajío Fault System. Furthermore, the high exhumation rate in the Comanja Granite suggests that gravitational collapse played an important role during exhumation.
Ein Feuer entzündet das andere: Krisen und die Führerschaft heiliger Männer und Frauen
Creators: name: Johnson, Elizabeth A.
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 41 Nr. 3 (2005): Concilium: Internationale Zeitschrift für Theologie, Band 41, Heft 3
Communicating Beyond the Information Given Can Make the Communicator’s Attitudes Toward a Social Group More Extreme
Creators: name: Decker, Kaleigh
name: Lord, Charles
name: Holland, Christopher
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences

description: Three experiments tested how communicating attributes of initially liked or disliked groups might create more extreme attitudes. We gave non-neutral participants information about previously unknown groups and asked them to write social media posts describing the group to others. Participants who wrote social media posts to friends (Experiment 1, n = 332) or undecided strangers (Experiments 2 and 3, ns = 113 and 816) exaggerated and elaborated on initial information, subsequently reporting more extreme attitudes. These effects, mediated by extremity of associations to the target group, were interpreted as consistent with theory and research on going beyond the information given.
Novel Digital Media Software Teaching and Performance Evaluation on Adobe Illustrator CC 2022
Creators: name: Semwaiko, Godfrey
Publisher: name: figshare
Year: 2023
Subjects: Fine arts
Visual arts not elsewhere classified
Educational technology and computing
Creative arts, media and communication curriculum and pedagogy

description: Digital drawing and the use of digital tools have been a challenge to many students in their artistic development,although it is important to use computers to support learners to explore, understand, and practice their creativityin the virtual world. Challenges to them in the digital drawing, have been either not knowing how to use the tools,or distraction from several items in the software interface. This paper aimed to study the impact of using Shapeand Shape Builder Tools in Adobe Illustrator CC 2022, to draw a simple human figure for middle school students.At first, a class sample of 19 students drew simple human figures without a demonstration of how to usegeometrical shapes. Then, students got a demonstration on how to use the shape tool and shape builder tool indrawing a simple balanced human figure. Afterward, students practiced what they have learned from thedemonstration. Results indicated that 17 out of 19 students understood the practice of drawing a simple humanfigure in Adobe Illustrator CC 2022. With the significant use of digital tools and specific assessment methods, wecan now fully see that there is an impact to manifest on digital drawing and education development
Methane, Carbon Monoxide, and Ammonia in Brown Dwarfs and Self-Luminous Giant Planets
Creators: name: Zahnle, Kevin J.
name: Marley, Mark S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We address disequilibrum abundances of some simple molecules in the atmospheres of solar composition brown dwarfs and self-luminous extrasolar giant planets using a kinetics-based 1D atmospheric chemistry model. Our approach is to use the full kinetics model to survey the parameter space with effective temperatures between 500 K and 1100 K. In all of these worlds equilibrium chemistry favors CH4 over CO in the parts of the atmosphere that can be seen from Earth, but in most disequilibrium favors CO. The small surface gravity of a planet strongly discriminates against CH4 when compared to an otherwise comparable brown dwarf. If vertical mixing is like Jupiter's, the transition from methane to CO occurs at 500 K in a planet. Sluggish vertical mixing can raise this to 600 K; but clouds or more vigorous vertical mixing could lower this to 400 K. The comparable thresholds in brown dwarfs are $1100\pm100$ K. Ammonia is also sensitive to gravity, but unlike CH4/CO, the NH3/N2 ratio is insensitive to mixing, which makes NH3 a potential proxy for gravity. HCN may become interesting in high gravity brown dwarfs with very strong vertical mixing. Detailed analysis of the CO-CH4 reaction network reveals that the bottleneck to CO hydrogenation goes through methanol, in partial agreement with previous work. Simple, easy to use quenching relations are derived by fitting to the complete chemistry of the full ensemble of models. These relations are valid for determining CO, CH4, NH3, HCN, and CO2 abundances in the range of self-luminous worlds we have studied but may not apply if atmospheres are strongly heated at high altitudes by processes not considered here (e.g., wave breaking).
description: Astrophysical Journal, in press. Clarity improvements throughout and one new figure. 17 figures, 20 pages
Vector Parallel architecture for graphics acceleration in FPGA
Creators: name: Sathyanarayanan, Karthik
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400903
subject: Digital processor architectures
classificationCode: 400902
subject: Digital electronic devices
classificationCode: 400904
subject: Electronic device and system performance evaluation, testing and simulation

description: This project designs a ARM System on Chip which displays a jagged Christmas tree using both, just the included processor of the system on chip as well as a dedicated hardware accelerator module which accelerates the rasterisation of triangles. This is displayed on a 640x480 VGA screen connected to an Intel DE-1 FPGA
Conformational coupling in the chemotaxis response regulator CheY
Creators: name: Silversmith, R. E.
name: Bourret, R. B.
name: Schuster, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: CheY, a response regulator protein in bacterial chemotaxis, serves as a prototype for the analysis of response regulator function in two-component signal transduction. Phosphorylation of a conserved aspartate at the active site mediates a conformational change at a distal signaling surface that modulates interactions with the flagellar motor component FliM, the sensor kinase CheA, and the phosphatase CheZ. The objective of this study was to probe the conformational coupling between the phosphorylation site and the signaling surface of CheY in the reverse direction by quantifying phosphorylation activity in the presence and absence of peptides of CheA, CheZ, and FliM that specifically interact with CheY. Binding of these peptides dramatically impacted autophosphorylation of CheY by small molecule phosphodonors, which is indicative of reverse signal propagation in CheY. Autodephosphorylation and substrate affinity, however, were not significantly affected. Kinetic characterization of several CheY mutants suggested that conserved residues Thr-87, Tyr-106, and Lys-109, implicated in the activation mechanism, are not essential for conformational coupling. These findings provide structural and conceptual insights into the mechanism of CheY activation. Our results are consistent with a multistate thermodynamic model of response regulator activation.
Does the Internet Search Index Precede the Purchase of Agro-food Products?
Creators: name: Rho, Hoyoung
name: Rho, Hoyoung
Publisher: name: Unknown
Year: 2019
Subjects: subject: Consumer/Household Economics
subject: Internet Search Index
subject: Agri-food products purchases
subject: Vector Autoregressive

description: The purpose of this paper is to demonstrate the usefulness of Internet search data in the rapid prediction of food consumption at the retail stage. For 30 agricultural food products, which are the very topics in the KREI's Agricultural Outlook, we collected the internet search index provided by Naver Data Lab and the consumers' daily purchasing costs obtained from the Agri-Food Consumers Panel Survey conducted by the Korea RDA. We utilized time-series analysis such as VAR model, Granger Causality test and Impulse Response Function, and verified whether the Internet search index of each item preceded its purchases. According to the empirical results, 24 out of the total 30 items showed that their search index and purchase amounts were inter-influential or that the search index influenced only their costs of purchasing items. It was also found that the more they searched the Internet for information on an item, the higher the probability was of buying the item in about 5 to 6 days. For 80% of the items, past Internet search activities had positive and negative effects on its current purchases. Considering that the data in the consumption outlook was is not sufficient to identify and predict real-time food consumption trends, the Internet search index can be an effective alternative at low cost.
Intermodulation electrostatic force microscopy for imaging surface photo-voltage
Creators: name: Borgani, Riccardo
name: Forchheimer, Daniel
name: Bergqvist, Jonas
name: Thorén, Per-Anders
name: Inganäs, Olle
name: Haviland, David B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate an alternative to Kelvin Probe Force Microscopy for imaging surface potential. The open-loop, single-pass technique applies a low-frequency AC voltage to the atomic force microscopy tip while driving the cantilever near its resonance frequency. Frequency mixing due to the nonlinear capacitance gives intermodulation products of the two drive frequencies near the cantilever resonance, where they are measured with high signal to noise ratio. Analysis of this intermodulation response allows for quantitative reconstruction of the contact potential difference. We derive the theory of the method, validate it with numerical simulation and a control experiment, and we demonstrate its utility for fast imaging of the surface photo-voltage on an organic photo-voltaic material.
description: 4 pages, 3 figures, peer-reviewed, preprint
(Dis)Honoured Bodies: The Impact of the “Ideal” Victim on Redress for South Korea’s Sex Slaves
Creators: name: Mills, Charlotte E.
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: The sexual enslavement of Korean women has been an ongoing human rights issue in South Korea since WW2, with sexual slavery also occurring during the Korean War, within the US military camp-towns, and in contemporary Korean society. Consequently, women have been marginalised and silenced, with victim-survivors struggling to receive full legal redress from their perpetrators. This is despite a redress movement that appeared alongside the first public testimony of WW2 sex slave survivor, Kim Hak-sun, in 1991. Since Kim Hak-sun’s testimony, the experiences of South Korean sex slaves have been contested. This has resulted in the Korean state “fighting” to control survivors’ narratives, victimhood, and the wider victimhood of the nation. Whilst this approach has led to WW2 sex slave survivors and their redress movement receiving support, the effect has been a creation of a hierarchy of victimhood that seemingly values one collective experience of sexual slavery (WW2) over others, further marginalising Korean women. This thesis examines the silencing of South Korean victim-survivors of sexual slavery from WW2 to the present day. It analyses the provision of redress for Korean sexual slaves through the lens of an “ideal” victim, one used to separate “legitimate” victims from perceived “willing prostitutes”. It unravels this “ideal” victim construct – how it came about and for what purpose - and assesses its impact upon the survivors’ pursuit of redress. It argues that this construct is the result of a combination of socio-cultural norms and the state’s desire to build national identity after decades of colonialism, war, and authoritarianism. Combined, these factors influence the development of Korean law and determine whether redress is provided to female victims. Ultimately, this thesis contends that analysing the “ideal” victim provides an explanation as to why all Korean sexual slavery victim-survivors remain marginalised and have yet to receive truth and justice.
Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO
Creators: name: Eu, J. P.
name: Xin, C.
name: Meissner, G.
name: Stamler, J. S.
name: Sun, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: We have shown previously that at physiologically relevant oxygen tension (pO2 ≈ 10 mmHg), NO S-nitrosylates 1 of ≈50 free cysteines per ryanodine receptor 1 (RyR1) subunit and transduces a calcium-sensitizing effect on the channel by means of calmodulin (CaM). It has been suggested that cysteine-3635 is part of a CaM-binding domain, and its reactivity is attenuated by CaM [Porter Moore, C., Zhang, J. Z., Hamilton, S. L. (1999) J. Biol. Chem. 274, 36831–36834]. Therefore, we tested the hypothesis that the effect of NO was mediated by C3635. The full-length RyR1 single-site C3635A mutant was generated and expressed in HEK293 cells. The mutation resulted in the loss of CaM-dependent NO modulation of channel activity and reduced S-nitrosylation by NO to background levels but did not affect NO-independent channel modulation by CaM or the redox sensitivity of the channel to O2 and glutathione. Our results reveal that different cysteines within the channel have been adapted to serve in nitrosative and oxidative responses, and that S-nitrosylation of the cysteine-containing CaM-binding domain underlies the mechanism of CaM-dependent regulation of RyR1 by NO.
Ecosystem impacts of three sequential hurricanes (Dennis, Floyd, and Irene) on the United States' largest lagoonal estuary, Pamlico Sound, NC
Creators: name: Crowder, L. B.
name: Eby, L. A.
name: Ramus, J. S.
name: Bales, J. D.
name: Go, M.
name: Buzzelli, C. P.
name: Fear, J. M.
name: Peierls, B. L.
name: Richardson, T. L.
name: Paerl, H. W.
name: Ausley, L. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Three sequential hurricanes, Dennis, Floyd, and Irene, affected coastal North Carolina in September and October 1999. These hurricanes inundated the region with up to 1 m of rainfall, causing 50- to 500-year flooding in the watershed of the Pamlico Sound, the largest lagoonal estuary in the United States and a key West Atlantic fisheries nursery. We investigated the ecosystem-level impacts on and responses of the Sound to the floodwater discharge. Floodwaters displaced three-fourths of the volume of the Sound, depressed salinity by a similar amount, and delivered at least half of the typical annual nitrogen load to this nitrogen-sensitive ecosystem. Organic carbon concentrations in floodwaters entering Pamlico Sound via a major tributary (the Neuse River Estuary) were at least 2-fold higher than concentrations under prefloodwater conditions. A cascading set of physical, chemical, and ecological impacts followed, including strong vertical stratification, bottom water hypoxia, a sustained increase in algal biomass, displacement of many marine organisms, and a rise in fish disease. Because of the Sound's long residence time (≈1 year), we hypothesize that the effects of the short-term nutrient enrichment could prove to be multiannual. A predicted increase in the frequency of hurricane activity over the next few decades may cause longer-term biogeochemical and trophic changes in this and other estuarine and coastal habitats.
Root growth of forests on peatlands with a high pH subsoil or marl layer
Creators: name: Pitcher Farrell, Jill
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Inhibited growth is observed in many forest stands planted on marl and other calcareous soils. Currently in Ireland, state grant aid for afforestation is refused on sites which contain marl or other material which audibly or visibly reacts when dilute Hydrochloric acid (Hcl) is applied (reactive layer), within 70 cm of the soil surface. This known as acid testing or fizz testing and the reaction occurs to due carbon dioxide evolution when dilture Hcl contacts carbonate soil material. The aims of this study were to investigate siites where forests have been established on marl or other calacareous soils, investigate if these subsoils are root limiting environments comparing both soil physical and soil checmical properties with root numbers and to investigate the validity of the field ‘Acid Test’ as utilised in Irish Forest Policy. Initial analysis was completed on 50 forest stands of which 19 were selected for further investigation. Tree species included; alder, sycamore, Sitka spruce, Norway spruce, Scots pine and birch. These sites were located in the midlands of Ireland. An investigation was conducted into the presence of reactive layers composed of marl or other high pH material in the soil, the soil properties, and the penetration of the tree roots into the calcareous layer. Tree growth above ground was assessed in a separate study. A soil-coring survey sampled the boundary between the calcareous layer and the overlying soil to distinguish between root penetrating and root-restricting environments. Split-tube undisturbed root cores of 40 cm length and 7 cm diameter were collected, three methods of root analysis were utilised; the core break method, X-Ray Computed Tomography (CT) and WinRHIZOTM 2D scanning and software. Analysis of root scanning images showed roots penetrating all reactive layers. Soil samples were collected at each site and pH, acidneutralising capacity (ANC) andsoil organic matter content were analysed. Soil properties were then compared to root numbers. Soil physical properties: porosity and penetration resistance (PR) were seen to have a statistically significant relationship with root count whilst soil chemical properties; pH and Effervescence Class (EC) did not. The use of the three methods of root analysis was also analysed and the combination of method utilised was beneficial to provide a variety of both quantitative and qualitative data. These results indicate that the use of the ‘acid test’ may not be the most efficient method to indicate a soil’s suitability for forestry and a pocket penetrometer may be a better in field test for a root-restricting environment.