cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cardiac mitochondria alteration and peripheral vessel morphology in female diabetes
Creators: name: Solinas, P.
name: Isola, M.
name: Lilliu, M.A.
name: Loy, F.
name: Vargiu, R.
name: Isola, R.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Diabetes; heart mitochondria; OXPHOS; aorta; portal vein.

description: One of diabetes complications is chronic cardiomyopathty and fibrotic alteration of aorta and peripheral vessels. Diabetes has been correlated to ROS superproduction (Lashin et al., 2006) and an alteration of mitochondrial chain complexes function in the whole heart (Herelin et al., 2011). Despite diabetic cardiomyopathy is most frequent in women, to date studies on female experimental diabetic models are lacking. Our aim was to investigate on heart mitochondrial oxygen phosphorylation (OXPHOS), and on aorta and portal vein morphology in female Wistar rats, after 4 and half months of streptozotocin-induced (65 mg/kg) diabetes. Mitochondrial OXPHOS was assessed by means of a Clark-type electrode on the following isolated mitochondrial subpopulations: left and right ventricles subsarcolemmal (SSM) and interfibrillar (IFM) mitochondria. Morphology and extracellular matrix composition of aorta and portal vein were investigated in light microscopy on paraformaldehyde fixed samples, stained with Masson Trichrome method (for collagen fibers) and Weigert’s stain (for elastic fibers). Evaluation of OXPHOS revealed an impairment of complex II in mitochondrial diabetic female rats in left and right IFM, but not in SSM. Interestingly, administration of the substrate glutamate resulted in an improvement of complex I efficiency in left IFM only, while association of complex I and II substrates displayed a reduced efficiency both in left and right IFM. Neither administration of glucidic substrates on SSM or of lipidic substrates on both SSM and IFM resulted in any change of mitochondrial OXPHOS efficiency. The study of connective fibrous composition in aorta and vena porta revealed a slight more abundant collagen production in the aorta’s wall and a disorganized and fragmented aspect of elastic bundles in the portal vein. Taken together, these data suggest a peculiar unknown development of diabetic cardiopathy in female rats.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Crystallization of n-alkanes under anisotropic nanoconfinement in lipid bilayers
Creators: name: Wurl, Anika
name: Ott, Maria
name: Schwieger, Christian
name: Ferreira, Tiago M.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 540

description: Understanding crystallization behavior is integral to the design of pharmaceutical compounds for which the pharmacological properties depend on the crystal forms achieved. Very often, these crystals are based on hydrophobic molecules. One method for delivering crystal-forming hydrophobic drugs is by means of lipid nanoparticle carriers. However, so far, a characterization of the potential crystallization of fully hydrophobic molecules in a lipid environment has never been reported. In this work we investigate the crystallization behavior of two model hydrophobic chains, n-eicosane (C20) and n-triacontane (C30), in phospholipid bilayers. We combine static 2H nuclear magnetic resonance (NMR) spectroscopy and differential scanning calorimetry (DSC) and show that C30 molecules can indeed crystallize inside DMPC and POPC bilayers. The phase transition temperatures of C30 are slightly reduced inside DMPC, and rotator phase formation becomes a two-step process: Preorganized n-alkane chains assemble in rotator-phase crystallites just as fast as bulk C30, but further addition of molecules is notably slower. Under the same isothermal conditions, different crystal forms can be obtained by crystallization in the membrane and in bulk. In excess water conditions, homogeneous nucleation of C30 is observed. The initial anisotropic molecular arrangement of C30 molecules in the membrane is readily recovered upon reheating, showing reversibility. The shorter C20 molecules on the other hand become trapped in the DMPC membrane gel-phase upon cooling and do not crystallize. This work marks the first observation of the crystallization of hydrophobic chains inside a lipid bilayer environment. As such, it defines a fundamental starting point for studying the crystallization characteristics of various hydrophobic molecules in lipid membranes.
Strained graphene: tight-binding and density functional calculations
Creators: name: Ribeiro, R. M.
name: Pereira, Vitor M.
name: Peres, N. M. R.
name: Briddon, P. R.
name: Neto, A. H. Castro
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We determine the band structure of graphene under strain using density functional calculations. The ab-initio band strucure is then used to extract the best fit to the tight-binding hopping parameters used in a recent microscopic model of strained graphene. It is found that the hopping parameters may increase or decrease upon increasing strain, depending on the orientation of the applied stress. The fitted values are compared with an available parametrization for the dependence of the orbital overlap on the distance separating the two carbon atoms. It is also found that strain does not induce a gap in graphene, at least for deformations up to 10%.
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ ÐºÐ²Ð°Ð½ÑÐ¾Ð²Ð¾-ÐºÐ°ÑÐºÐ°Ð´Ð½ÑÑ Ð»Ð°Ð·ÐµÑÐ½ÑÑ ÑÑÑÑÐºÑÑÑ Ð½Ð° Ð´Ð»Ð¸Ð½Ñ Ð²Ð¾Ð»Ð½Ñ 4,8 Ð¼ÐºÐ¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð·Ð°Ð½ÑÐµÐ², ÐÐ°ÑÐº
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐºÐ²Ð°Ð½ÑÐ¾Ð²Ð¾-ÐºÐ°ÑÐºÐ°Ð´Ð½ÑÐµ Ð»Ð°Ð·ÐµÑÑ
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ÐºÐ°ÑÐºÐ°Ð´
ÑÐ¿ÐµÐºÑÑ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ

description: Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð° Ð³ÐµÐ½ÐµÑÐ°ÑÐ¸Ñ Ð¼Ð½Ð¾Ð³Ð¾Ð¿ÐµÑÐ¸Ð¾Ð´Ð½ÑÑ ÐºÐ²Ð°Ð½ÑÐ¾Ð²Ð¾-ÐºÐ°ÑÐºÐ°Ð´Ð½ÑÑ Ð»Ð°Ð·ÐµÑÐ¾Ð² Ð½Ð° Ð´Ð»Ð¸Ð½Ðµ Ð²Ð¾Ð»Ð½Ñ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ 4,8 Ð¼ÐºÐ¼ Ð² Ð¸Ð¼Ð¿ÑÐ»ÑÑÐ½Ð¾Ð¼ ÑÐµÐ¶Ð¸Ð¼Ðµ Ð² Ð´Ð¸Ð°Ð¿Ð°Ð·Ð¾Ð½Ðµ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑ 80-300 Ð, Ð¸Ð·Ð¼ÐµÑÐµÐ½Ñ Ð²Ð¾Ð»ÑÑ-Ð°Ð¼Ð¿ÐµÑÐ½ÑÐµ Ð¸ Ð²Ð°ÑÑ-Ð°Ð¼Ð¿ÐµÑÐ½ÑÐµ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸, ÑÐ¿ÐµÐºÑÑÑ ÑÐ¿Ð¾Ð½ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ Ð¸ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ð¹ Ð´Ð»Ñ ÑÐµÑÐ¸Ð¸ Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð², Ð¿ÑÐµÐ´Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÑ Ð¤Ð¢Ð Ð¸Ð¼. Ð. Ð¤. ÐÐ¾ÑÑÐµÐ ÐÐ.
Late glacial summer paleohydrology across Central Europe
Creators: name: Prochnow, Maximilian
name: Hepp, Johannes
name: Strobel, Paul
name: Zech, Roland
name: Acharya, Sudip
name: Szidat, Sönke
name: Rius, Damien
name: Millet, Laurent
name: Glaser, Bruno
name: Zech, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 554

description: It is generally accepted that a weakening of the North Atlantic thermohaline circulation caused the Younger Dryas cooling. Although the role of seasonality was emphasized previously, this aspect is rarely considered yet, and it remains elusive how this impacted hydroclimate during winters and summers across Central Europe. Here, we coupled biomarker-based δ18O and δ2H from Bergsee in southern Germany to reconstruct deuterium excess as a proxy for evaporation history from the Bølling-Allerød to the Preboreal. We compared this dataset with other biomarker isotope records in Central Europe. They are all lacking a strong isotopic depletion during the Younger Dryas, which is best explained by the summer sensitivity of the biomarker proxies: As Younger Dryas summers were relatively warm, there is an absence of the strong winter cooling signals recorded in annual water isotope records like Greenland or Lake Steißlingen. Lake evaporation at Bergsee together with other paleohydrological reconstructions draw a coherent picture of the Late Glacial hydroclimate, with strong evidence for warm and dry Younger Dryas summers. Rather than a southward shift of the Westerlies during winter, we suggest that a recently proposed feedback mechanism between North Atlantic sea ice extend, strong winter cooling and summer atmospheric blocking serves as a suitable explanation for summer dryness. Additional confidence to the robustness of these biomarker records is provided by the overall agreement of paleohydrological fluctuations during the Preboreal.
Spettri spaziali con lo specchio ultragelido
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2019

Costo stimato un miliardo di euro, da dividere grosso modo a metà fra Esa e Jaxa, lo Space Infrared telescope for Cosmology and Astrophysics è uno dei tre candidati in gara alla selezione per la selezione M5 della Cosmic Vision Esa. Ne parliamo con il responsabile italiano del progetto, Luigi Spinoglio dell’Inaf Iaps di Roma
Reconstruction of spatial qutrit states based on realistic measurement operators
Creators: name: Taguchi, Gen
name: Dougakiuchi, Tatsuo
name: Iinuma, Masataka
name: Hofmann, Holger F.
name: Kadoya, Yutaka
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Spatial qudit states can be realized by using multi-slits to discretize the transverse momentum of a photon. The merit of this kind of spatial qudit states is that the implementation of higher dimensional qudits is relatively easy. As we have recently shown, the quantum states of these spatial qudits can be analyzed by scanning a single interference pattern. This method of single scan tomography can also be applied at higher dimensions, but the reconstruction becomes more sensitive to smaller details of the scanned patterns as the dimensions increase. In this paper, we investigate the effect of finite measurement resolution on the single scan tomography of spatial qutrits. Realistic measurement operators describing the spatial resolution of the measurement are introduced and the corresponding pattern functions for quantum state reconstruction are derived. We use the pattern functions to analyze experimental results for entangled pairs of spatial qutrits generated by spontaneous parametric down-conversion (SPDC). It is shown that a reliable reconstruction of the quantum state can be achieved with finite measurement resolution if this limitation of the measurement is included in the pattern functions of single scan tomography.
description: 15 pages, including 8 figures
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÑÐ¾Ð±ÑÑÐ¸Ð¹ ÐºÐ°Ðº Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½Ñ PR-Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ¼Ñ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÐÐ Â«Ð®Ð½Ð¸ÐºÐ¾ÑÐ¼ÐµÑÐ¸ÐºÂ»)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: Ð¤ÑÐ½Ð¸ÐºÐ¾Ð²Ð°, Ð¡Ð²ÐµÑÐ»Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: SWOT-Ð°Ð½Ð°Ð»Ð¸Ð·
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ÑÐµÐ»ÐµÐ²Ð¸Ð·Ð¸Ð¾Ð½Ð½Ð°Ñ ÑÐµÐºÐ»Ð°Ð¼Ð°
PR-Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ðµ

description: ÐÐ°Ð½Ð½Ð°Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÑÐ¾Ð±ÑÑÐ¸Ð¹ ÐºÐ°Ðº Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÑ PR-Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ¼Ñ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÐÐ Â«Ð®Ð½Ð¸ÐºÐ¾ÑÐ¼ÐµÑÐ¸ÐºÂ»). Ð ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÐºÑÑÐ²Ð°ÑÑÑÑ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÑÐ¾Ð±ÑÑÐ¸Ð¹ Ð² beauty-ÑÑÐµÑÐµ Ð¸ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¸Ñ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ SWOT Ð¸ PEST Ð°Ð½Ð°Ð»Ð¸Ð·Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Estel Professional. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ ÑÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ñ PR-Ð¿ÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Ð¿ÑÑÐµÐ¼ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½ÑÑ ÑÐ¾Ð±ÑÑÐ¸Ð¹, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿ÑÐ¾ÐµÐºÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð¿ÑÐ¸Ð½ÑÑÑÐ¹ Ð½Ð° ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð¸Ðµ ÑÑÐºÐ¾Ð²Ð¾Ð´ÑÑÐ²Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸.
M17: quanti nomi per una sola nebulosa
Creators: Marco Galliani
Publisher: name: Media Inaf
Year: 2019

La nebulosa Messier 17 o M17 in breve solo è uno degli oggetti celesti che caratterizzano il cielo di questo mese. I consigli per osservarla, insieme a costellazioni, pianeti e fenomeni visibili in Italia a giugno
Asteroide doppio immortalato dal Vlt
Creators: Redazione Eso
Publisher: name: Media Inaf
Year: 2019

Le eccezionali capacità dello strumento Sphere installato sul Vlt dell’Eso hanno permesso di ottenere immagini nitidissime di 1999 KW4 di passaggio vicino alla Terra il 25 maggio. Mentre questo asteroide doppio non è di per sé un oggetto minaccioso, gli scienziati hanno colto l’occasione per collaudare la risposta a Near-Earth Object, dimostrando che la tecnologia di prima linea dell’Eso potrebbe rivelarsi fondamentale nella difesa planetaria
Astroglial networks in health and disease: New Frontiers
Creators: name: Verkhratsky, Alexei
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Neuroglia; astrocyte; astroglial networks; neuropathology; neurodegeneration

description: The common and prevailing point of view considers neurones as main substrates of pathological progression of neurological diseases. Today, however, we know that integration and information processing in the brain occurs though close interactions of two cellular circuits represented by neuronal networks embedded into internally connected astroglial syncytia. Our understanding of glial function changed dramati- cally over last two decades. This change concerns the whole concept of how the brain is organized, and how the development, life and death of neural circuits are controlled. There is compelling evidence demonstrating that these are the astrocytes that are creating the compartmentalisation in the CNS, and these are the astrocytes that are able to integrate neurones, synapses, and brain capillaries into individual and relatively independent units. Astroglial syncytia allow intercellular communica- tion routes, which permit translocation of ions, metabolic factors and second messen- gers. The resulting potential for parallel processing and integration is significant and might easily be larger, but also fuzzier, than the binary coded electrical communica- tion within the neuronal networks. The neuronal-glial circuitry endowed with distinct signalling cascades, form a “diffuse nervous net” suggested by Golgi, where millions of synapses belonging to very different neurones are integrated first into neuronal- glial-vascular units and then into more complex structures connected through glial syncytia. These many levels of integration, both morphological and functional, pre- sented by neuronal-glial circuitry ensure the spatial and temporal multiplication of brain cognitive power.
Neuroglial cells are intimately involved in all forms of neurological diseases and this are neuroglia, which, to a very large extent, determine the progression and outcome of neuropathological process. Astrocytes are specifically involved in vari- ous neurodegenerative diseases including Alzheimer’s disease, Amyotrophic lateral sclerosis, Parkinson’s disease and various forms of dementia. Recent evidence sug- gest that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotrans- mitter homeostasis and neuronal death through increased excitotoxicity. At the later stages astrocytes became activated and contribute to neuro-inflammatory component of neurodegeneration.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
title: ÐÐµÐ¾Ð±Ñ Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÑ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÐ¾Ð¿Ð»Ð¸Ð²Ð½Ð¾-ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° ÑÐµÑÐ¿ÑÐ±Ð»Ð¸ÐºÐ¸ ÐÑÐ°ÐºÐ°
title: The need for planning for the development of the fuel and power complex of the republic of Iraq
Creators: name: ÐÐ°ÐºÐ°ÑÐµÐ½Ñ, Ð¢Ð°ÑÑÑÐ½Ð°
name: ÐÐ»Ð¸ ÐÐ»Ñ-Ð£Ð±Ð°Ð¹Ð´Ð¸ ÐÑ Ð¼ÐµÐ´ ÐÐ±ÑÐ°Ð³Ð¸Ð¼ Ð¥ÑÑÐµÐ¹Ð½
name: "Ð¡Ð¸ÑÑÐµÐ¼Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð² Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¸", Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð°Ñ Ð½Ð°ÑÑÐ½Ð°Ñ Ð¸ ÑÑÐµÐ±Ð½Ð¾-Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ñ (25; 2021; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³)
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2021
Subjects: Ð¢Ð¾Ð¿Ð»Ð¸Ð²Ð½Ð¾-ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÑ
ÐÐµÑÑÐµÐ´Ð¾Ð±ÑÑÐ°
Ð ÐµÑÐ¿ÑÐ±Ð»Ð¸ÐºÐ° ÐÑÐ°Ðº
Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ

description: Ð ÑÑÐ°ÑÑÐµ Ð¸ÑÑÐ»ÐµÐ´ÑÐµÑÑÑ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð° ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÐ¾Ð¿Ð»Ð¸Ð²Ð½Ð¾-ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¾ÑÑÐ°ÑÐ»Ð¸ ÐºÐ°Ðº ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÐºÐ¾Ð½ÐºÑÑÐµÐ½ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð° Ð² ÐÑÐ°ÐºÐµ Ñ ÑÐ¾ÑÐºÐ¸ Ð·ÑÐµÐ½Ð¸Ñ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÑ ÑÐµÐ»ÐµÐ¹ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ. Ð¡Ð´ÐµÐ»Ð°Ð½Ñ Ð²ÑÐ²Ð¾Ð´Ñ Ð¾ ÑÐµÐ½Ð´ÐµÐ½ÑÐ¸ÑÑ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ, Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð°Ñ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð¸ Ð´Ð°Ð½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ Ð²ÐºÐ»Ð°Ð´Ñ Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¸ ÐÑÐ°ÐºÐ°.
description: The article examines the problem of the development of the fuel and energy of, as the strategic competitive approach in Iraq. This connection is in terms of promising development goals. Conclusions on the trends of economic development, problems of the energy complex are presented and recommendations of the Iraq economy are given.
Integral Menger curvature for surfaces
Creators: name: Strzelecki, Pawel
name: von der Mosel, Heiko
Publisher: name: arXiv
Year: 2009
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 28A75, 49Q10, 49Q20, 53A05, 53C21, 46E35

description: We develop the concept of integral Menger curvature for a large class of nonsmooth surfaces. We prove uniform Ahlfors regularity and a $C^{1,λ}$-a-priori bound for surfaces for which this functional is finite. In fact, it turns out that there is an explicit length scale $R>0$ which depends only on an upper bound $E$ for the integral Menger curvature $M_p(Σ)$ and the integrability exponent $p$, and \emph{not} on the surface $Σ$ itself; below that scale, each surface with energy smaller than $E$ looks like a nearly flat disc with the amount of bending controlled by the (local) $M_p$-energy. Moreover, integral Menger curvature can be defined a priori for surfaces with self-intersections or branch points; we prove that a posteriori all such singularities are excluded for surfaces with finite integral Menger curvature. By means of slicing and iterative arguments we bootstrap the Hölder exponent $λ$ up to the optimal one, $λ=1-(8/p)$, thus establishing a new geometric `Morrey-Sobolev' imbedding theorem. As two of the various possible variational applications we prove the existence of surfaces in given isotopy classes minimizing integral Menger curvature with a uniform bound on area, and of area minimizing surfaces subjected to a uniform bound on integral Menger curvature.
description: 64 pages, 7 figures. Submitted. Version 2: extended comments on the relation to Lerman's and Whitehouse's work on Menger curvatures
Tumor angiogenesis. From bench to bedside
Creators: name: Ribatti, Domenico
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015

description: Under physiological conditions, angiogenesis is regulated by the local balance between endogenous stimulators and inhibitors. In recent years, evidence has accu- mulated that, in addition to the classic factors, many other endogenous peptides play an important regulatory role in angiogenesis, especially under pathological con- ditions. In chronic inflammation and tumor growth, there is an imbalance between endogenous stimulator and inhibitor levels, leading to an “angiogenic switch”. Vari- ous regulatory elements control the switch to the vascular phase. Endothelial cell turnover in the healthy adult organism is low, the quiescence being maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stim- uli. In pathological situations angiogenesis may be triggered not only by the over- production of pro-angiogenic factors, but also by the down-regulation of inhibitory factors. The stromal microenvironment is essential for cell proliferation and angiogen- esis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. Tumor cells are surrounded by an infiltrate of inflammatory cells, namely lymphocytes, neutrophils, macrophages, and mast cells, which communicate via a complex network of intercellular signaling path- ways mediated by surface adhesion molecules, cytokines, and their receptors. Much research effort has been concentrated on the role of angiogenesis in cancer, and inhi- bition of angiogenesis is a major area of therapeutic development for the treatment of this disease. New pathophysiological concepts generated in the past few decades have given rise to the development of a large variety of new drugs to interfere with angiogenesis. Angiogenesis inhibitors are now being approved and introduced into medical practice throughout the world and inhibition of angiogenesis is a major area of therapeutic development for the treatment of cancer. However, even if the major- ity of pre-clinical studies have shown that the growth of all experimental tumors can be effectively inhibited by various anti-angiogenic agents, the clinical benefits of anti- angiogenic treatments are relatively modest, and in the majority of cases, the drugs merely slow down tumor progression and prolong survival by only a few more months.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Vita in condizioni estreme scoperta in Etiopia
Creators: Stefano Parisini
Publisher: name: Media Inaf
Year: 2019

Un gruppo internazionale di ricerca, a cui ha partecipato l’astrobiologa Barbara Cavalazzi dell’Università di Bologna, ha individuato la presenza di nanobatteri nelle sorgenti idrotermali del vulcano etiope Dallol, una delle aree più inospitali della Terra, simile a come potevano presentarsi in tempi antichi alcune zone della superficie di Marte
Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism
Creators: name: Mohib, Mohammad Mohabbulla
name: Rabe, Sindy
name: Nolze, Alexander
name: Rooney, Michael
name: Ain, Quratul
name: Zipprich, Alexander
name: Gekle, Michael
name: Scheier, Barabara
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background: Recent studies suggest a contribution of intrahepatic mineralocorticoid receptor (MR) activation to the development of cirrhosis. As MR blockade abrogates the development of cirrhosis and hypoxia, common during the development of cirrhosis, can activate MR in hepatocytes. But, the impact of non-physiological hepatic MR activation is unknown. In this study, we investigate the impact of hypoxia-induced hepatocyte MR activation as a relevant factor in cirrhosis. Methods: RNA sequencing followed by gene ontology term enrichment analysis was performed on liver samples from rats treated for 12 weeks with or without CCl4 and for the last four weeks with or without eplerenone (MR antagonist). We investigated if these changes can be mimicked by hypoxia in a human hepatocyte cell line (HepG2 cells) and in primary rat hepatocytes (pRH). In order to evaluate the functional cellular importance, hepatocyte lipid accumulation, glucose consumption, lactate production and mitochondrial function were analyzed. Results: In cirrhotic liver tissue genes annotated to the GOterm “Monocarboxylic acid metabolic process” (PPARα, PDK4, AMACR, ABCC2, Lipin1) are downregulated. This effect is reversed by the MR antagonist eplerenone in vivo. The alterations are partially mimicked by hypoxia in rat and human hepatocytes in tissue culture. Furthermore, the reduction of mRNA and protein expression of PPARα, PDK4, AMACR, ABCC2 and Lipin1 during hypoxia is prevented by eplerenone in rat and human hepatocytes. Aldosterone, the endogenous MR agonist, did not affect the expression of those proteins in hepatocytes. As those proteins are key regulators of hepatocyte energy homeostasis, we analyzed if hypoxia affected glucose consumption, lactate production and lipid accumulation in HepG2 cells in a MR-mediated manner. All three parameters were affected by hypoxia and were partially normalized by eplerenone. Conclusion: Our findings suggest that non-physiological MR activation plays a role in the dysregulation of glucose and lipid metabolism in hepatocytes. This leads to an increase in apoptosis, probably resulting in a proinflammatory micromilieu of the hepatic tissue. The enhanced deposition of extracellular matrix contributes to the development of cirrhosis. Therefore, MR antagonists may have therapeutic potential in the treatment of early stages of liver disease due to their direct action in the liver.
Alla scoperta dello Square Kilometre Array
Creators: Redazione Media Inaf
Publisher: name: Media Inaf
Year: 2019

Un intero pomeriggio dedicato a far conosce al pubblico Ska, il radiotelescopio più potente al mondo. Con laboratori per bambini, proiezioni, spettacoli al planetario, visite guidate ai radiotelescopi e conferenze. L’evento è in programma per sabato prossimo a Medicina, in provincia di Bologna
A Roma Tre c’è la Luna giù in giardino
Creators: Livia Giacomini
Publisher: name: Media Inaf
Year: 2019

Torna anche quest’anno a Roma la manifestazione “Occhi sulla Luna”. Appuntamento al Dipartimento di matematica e fisica dell’Università Roma Tre, con la collaborazione dell’Inaf Iaps. Nell’occasione verrà presentata “LunaGarden”, una mostra diffusa sul nostro satellite, e sarà possibile scattarsi un selfie dal panorama lunare
Structural and ultrastructural evaluation of the effects induced by IL-22 alone or in combination with psoriatic cytokines in an ex-vivo human skin model
Creators: name: Arnaboldi, Francesca
name: Mastroianni, Nicolino
name: Baruffaldi Preis, Franz W.
name: Prignano, Francesca
name: Donetti, Elena
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Psoriasis; TEM; cytokines

description: L-22 is a pro-inflammatory cytokine playing a crucial role in the pathogenesis of psoriasis, an autoimmune chronic inflammatory skin disease. The immunological acti- vation during the progression of the psoriatic lesion is driven by IL-22 together with other cytokines, such as (TNF)-alpha and interleukin (IL)-17 [1]. The aim of our study was to evaluate the early, direct, and specific effect of IL-22 alone or in combination with TNF-alpha and IL-17 by immunofluorescence on i) the molecular composition of intercellular junctions (desmocollin (DSC)1, E-cadherin, and occludin), ii) keratin(K) 10 and 17 expression, iii) keratinocyte proliferation, and, by transmission electron micros- copy (TEM), on the ultrastructural morphology of the skin. An innovative model of human skin culture standardized in our laboratory, in which a psoriatic microenviron- ment was reproduced, was used [2]. Skin explants obtained from plastic surgery of healthy 20-40 year-old women (n = 7) after informed consent were cultured overnight in Dulbecco’s modified Eagle’s medium, divided before adding IL-22 or a combination of the three cytokines, and harvested 24, 48, and 72 hours after cytokine incubation.
Interestingly, keratinocyte proliferation was inhibited after exposure to the combi- nation of cytokines while was not affected by IL-22 incubation. In both experimental groups, starting from T24, occludin immunostaining was non homogeneously distrib- uted, K10 immunostaining gradually decreased in scattered clusters in the spinous layer, while K17 expression was induced and progressively increased with time in the suprabasal layers of epidermis. By TEM, after IL-22 incubation we observed keratin aggregates in the perinuclear cytoplasm of cells, while the combination of the three cytokines induced an enlargement of intercellular spaces.
Altogether, our results suggest that IL-22 mainly affects keratinocyte terminal dif- ferentiation, whereas, for inducing an impairment in cell proliferation, a more com- plex psoriatic-like microenvironment is needed.
description: Italian Journal of Anatomy and Embryology, Vol. 120, No. 1 (Supplement) 2015
Detection of X-rays from the jet-driving Symbiotic Star MWC 560
Creators: name: Stute, Matthias
name: Sahai, Raghvendra
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the detection of X-ray emission from the jet-driving symbiotic star MWC 560. We observed MWC 560 with XMM-Newton for 36 ks. We fitted the spectra from the EPIC pn, MOS1 and MOS2 instruments with XSPEC and examined the light curves with the package XRONOS. The spectrum can be fitted with a highly absorbed hard X-ray component from an optically-thin hot plasma, a Gaussian emission line with an energy of 6.1 keV and a less absorbed soft thermal component. The best fit is obtained with a model in which the hot component is produced by optically thin thermal emission from an isobaric cooling flow with a maximum temperature of 61 keV, which might be created inside an optically-thin boundary layer on the surface of the accreting with dwarf. The derived parameters of the hard component detected in MWC 560 are in good agreement with similar objects as CH Cyg, SS7317, RT Cru and T CrB, which all form a new sub-class of symbiotic stars emitting hard X-rays. Our previous numerical simulations of the jet in MWC 560 showed that it should produce detectable soft X-ray emission. We infer a temperature of 0.17 keV for the observed soft component, i.e. less than expected from our models. The total soft X-ray flux (i.e. at < 3 keV) is more than a factor 100 less than predicted for the propagating jet soon after its birth (<0.3 yr), but consistent with the value expected due its decrease with age. The ROSAT upper limit is also consistent with such a decrease. We find aperiodic or quasi-periodic variability on timescales of minutes and hours, but no periodic rapid variability. All results are consistent with an accreting white dwarf powering the X-ray emission and the existence of an optically-thin boundary layer around it.
description: 8 pages, 5 figure, accepted for publication in A & A
Compassionate Othering: the construction of refugee patients in medical students' narratives : a qualitative study using story completion
Creators: name: Bauer, Lena
name: Wienke, Andreas
name: Führer, Amand-Gabriel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background: Refugees remain a marginalized population and are exposed to a variety of discriminatory processes, among them Othering which categorizes people as belonging or not-belonging according to certain ascribed characteristics. We explored how the narrative construction of refugee patients by medical students constitutes a form of Othering. Methods: Using story completion, 124 5th year medical students at the Martin- Luther- University Halle-Wittenberg in October 2019 wrote a fictional story in response to a story stem situated in a medical practice. In a comparative approach, one patient presenting with abdominal pain lacks further characterization (version A) and the other is a refugee (version B). The stories were coded using qualitative content analysis by Mayring with a focus on content and narrative strategies (plot structure and perspective). Results: We identified four themes: characters, medical condition, access to care and provision of substandard care. The stories were predominantly framed with a medical or an interaction-based plot structure and written from a process-oriented perspective. The themes in version B, supported by their use of narrative strategies, were largely contextualized within the patients’ history of migration. An empathic depiction of patient B and the students’ compassion for the patients facing substandard care were key motifs as well. Conclusion: The perception of the version B patients predominantly as refugees establishes their construction as an Other. The students’ compassion acts as a representation of societal inequalities and remains an inept response without the tools to counter underlying discriminatory structures. Based on a discourse of deservingness, compassion alone therefore perpetuates Othering and highlights the need for structural competency training in medical school.
The photolysis of potassium cobaltioxalate in dilute acid solution
Creators: name: Doering, Juergen Gerhard Walter
Publisher: name: University of British Columbia
Year: 2012

description: A new sensitive spectrophotometric method for the direct determination of Co²⁺ ion in the presence of excess Co(III) was developed. Using this method the primary quantum yields for the photochemical decomposition of potassium cobaltioxalate were determined at pH 3 and 0°C over a wide range of wavelengths. The values for the various mercury lines were found to be: 280 mu, .369; 302 mu, .329; 313 mu, .362; 334 mu, .279; 365 mu, .244; 405 mu, .108; 435 mu, .067; 578 mu, ≤ .00033. The quantum yield for cobaltous ion formation is twice the primary quantum yield. No dependence of the quantum yield on the cobaltioxalate concentration was detected. The results are expected to be essentially the same in neutral solution because the instability constant of cobaltioxalate is extremely small. Correlation of the quantum yields with the absorption spectrum showed that photoactivity is considerable both for the electron transfer peak (in the U.V.) and the first d - d band (in the blue spectral region). Gaussian extrapolation of the absorption bands shows that a constant level of photoactivity cannot be directly assigned to each band. Further treatment of the data indicates that the quantum yields can be represented as two different functions of the logarithm of the light energy which however cannot be directly related to the two different types of transitions. The results are finally explained on the basis of internal conversion between the d - d and charge transfer bands.
Melica uniflora Retz
Creators: name: Cardona, Àngel Manuel Hernández
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Melica
Melica uniflora

description: Melica uniflora Retz
(mèlica uniflora). Present a una gran part d’Europa i muntanyes del Magreb. Prospera en boscos d’arbres caducifolis i en paratges humits. Hi és bastant freqüent en canals, sots, torrents i proximitats de fonts.
description: Published as part of Cardona, Àngel Manuel Hernández, 2022, Catàleg actualitzat i claus d'identificació de les gramínies de Sant Llorenç del Munt i l'Obac (Barcelona), pp. 64-86 in Nemus 12 on page 72, DOI: 10.5281/zenodo.12170499
A mechanism underlying improved dual-task performance after practice : reviewing evidence for the memory hypothesis
Creators: name: Schubert, Torsten
name: Kübler, Sebastian
name: Strobach, Tilo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 150

description: Extensive practice can significantly reduce dual-task costs (i.e., impaired performance under dual-task conditions compared with single-task conditions) and, thus, improve dual-task performance. Among others, these practice effects are attributed to an optimization of executive function skills that are necessary for coordinating tasks that overlap in time. In detail, this optimization of dual-task coordination skills is associated with the efficient instantiation of component task information in working memory at the onset of a dual-task trial. In the present paper, we review empirical findings on three critical predictions of this memory hypothesis. These predictions concern (1) the preconditions for the acquisition and transfer of coordination skills due to practice, (2) the role of task complexity and difficulty, and (3) the impact of age-related decline in working memory capacity on dual-task optimization.
title: Ð§ÐµÐ»Ð¾Ð²ÐµÐºÐ¾-Ð¼Ð°ÑÐ¸Ð½Ð½ÑÐ¹ Ð¸Ð½ÑÐµÑÑÐµÐ¹Ñ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐµÑ Ð° Ð´ÑÐ¾Ð±Ð»ÐµÐ½Ð¸Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾Ð»Ð¾Ð´Ð¸Ð½, Ð ÑÑÐ»Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: "Ð§ÐµÐ»Ð¾Ð²ÐµÐº Ð¸ Ð¼Ð°ÑÐ¸Ð½Ð°", ÑÐ¸ÑÑÐµÐ¼Ð°
ÐÐ½ÑÐµÑÑÐµÐ¹ÑÑ
ÑÐµÐ»Ð¾Ð²ÐµÐºÐ¾-Ð¼Ð°ÑÐ¸Ð½Ð½ÑÐ¹ Ð¸Ð½ÑÐµÑÑÐµÐ¹Ñ
Ð¿Ð¸Ð²Ð¾Ð²Ð°ÑÐµÐ½Ð½ÑÐµ Ð·Ð°Ð²Ð¾Ð´Ñ
Ð´ÑÐ¾Ð±Ð»ÐµÐ½Ð¸Ðµ ÑÐ¾Ð»Ð¾Ð´Ð°
"Man and machine", the system
man-machine interface
brewing plants
malt crushing

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ» ÑÐµÐ°Ð»Ð¸Ð·Ð¾Ð²Ð°Ð½ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ¾-Ð¼Ð°ÑÐ¸Ð½Ð½ÑÐ¹ Ð¸Ð½ÑÐµÑÑÐµÐ¹Ñ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐµÑÐ° Ð´ÑÐ¾Ð±Ð»ÐµÐ½Ð¸Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð°Ñ ÑÐ¸ÑÑÐµÐ¼Ð° Â«ÑÐµÐ»Ð¾Ð²ÐµÐº-Ð¼Ð°ÑÐ¸Ð½Ð°Â» Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¾Ð¿ÐµÑÐ°ÑÐ¾ÑÑÐºÐ¾Ð¹ Ð¿Ð°Ð½ÐµÐ»Ð¸ Ð½Ð° Ð±Ð°Ð·Ðµ Ð¿ÑÐ¾Ð¼ÑÑÐ»ÐµÐ½Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ° Ñ ÑÐµÐ½ÑÐ¾ÑÐ½ÑÐ¼ ÑÐºÑÐ°Ð½Ð¾Ð¼. ÐÐ¾Ð½ÐµÑÐ½ÑÐ¹ Ð²Ð°ÑÐ¸Ð°Ð½Ñ Ð§ÐµÐ»Ð¾Ð²ÐµÐºÐ¾-Ð¼Ð°ÑÐ¸Ð½Ð½Ð¾Ð³Ð¾ Ð¸Ð½ÑÐµÑÑÐµÐ¹ÑÐ° ÑÐ¿Ð¾ÑÐ¾Ð±ÐµÐ½ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÑÑ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÑ Ð½ÐµÐ¿Ð¾Ð»Ð°Ð´Ð¾Ðº, Ð²ÐµÑÑÐ¸ ÑÑÐµÑ Ð²ÑÐµÑ Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð½ÑÑ Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð¹, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑ ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²ÐºÑ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð¸ Ð·Ð°ÑÐ¸ÑÑ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¸. Ð Ð¿ÑÐ¾ÑÐµÑÑÐµ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð±ÑÐ»Ð° Ð¸Ð·ÑÑÐµÐ½Ð° Ð¸ Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð° ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð°Ñ ÑÑÐµÐ¼Ð° ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð´ÑÐ¾Ð±Ð»ÐµÐ½Ð¸Ñ ÑÐ¾Ð»Ð¾Ð´Ð°, ÑÑÐ¾ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ð»Ð¾ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¾Ð²Ð°ÑÑ ÐºÐ¾Ð½ÑÑÑÑ ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº, Ð½Ð°Ð¿ÑÑÐ¼ÑÑ Ð²Ð»Ð¸ÑÑÑÐ¸Ñ Ð½Ð° ÐºÐ°ÑÐµÑÑÐ²Ð¾ ÐºÐ¾Ð½ÐµÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ°. Ð¢Ð°ÐºÐ¶Ðµ Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ Ð²ÑÐ±Ð¾Ñ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ, Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾Ð³Ð¾ Ð´Ð»Ñ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð² Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÑÐµÐ´Ñ. ÐÑÐ¾Ð³Ð¾Ð¼ ÑÐ°Ð±Ð¾ÑÑ ÑÑÐ°Ð»Ð¾ ÑÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¸Ð½ÑÑÑÑÐºÑÐ¸Ð¸ Ð¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÐµÐ»Ñ.
description: In this work, we have implemented the man-machine interface of an automated system of ragging. The system "man-machine" is intended to be used as operator panel on the basis of industrial PC with touch screen. The final version of the Human-machine interface is designed to diagnose problems, keep records of all the transactions, ensure the adjustment of parameters and protection information.In the process of design of control system was studied and analyzed the functional diagram of the technological process of crushing of the malt, which helped to organize the loop characteristics directly affecting the quality of the final product. Also made the selection of equipment needed to implement management systems in a production environment. The result was the development of the user manual.
Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease
Creators: name: Bagherpoor Helabad, Mahdi
name: Matlahov, Irina
name: Kumar, Raj
name: Daldrop, Jan
name: Jain, Greeshma
name: Weingarth, Markus
name: Van Der Wel, Patrick C. A.
name: Miettinen, Markus S.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 540

description: Neurodegeneration in Huntington’s disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. Unlike amyloid fibrils from Parkinson’s and Alzheimer’s diseases, the atomic-level structure of HTTex1 fibrils has remained unknown, limiting diagnostic and treatment efforts. We present and analyze the structure of fibrils formed by polyQ peptides and polyQ-expanded HTTex1 in vitro. Atomic-resolution perspectives are enabled by an integrative analysis and unrestrained all-atom molecular dynamics (MD) simulations incorporating experimental data from electron microscopy (EM), solid-state NMR, and other techniques. Alongside the use of prior data, we report magic angle spinning NMR studies of glutamine residues of the polyQ fibril core and surface, distinguished via hydrogen-deuterium exchange (HDX). Our study provides a molecular understanding of the structure of the core as well as surface of aggregated HTTex1, including the fuzzy coat and polyQ–water interface. The obtained data are discussed in context of their implications for understanding the detection of such aggregates (diagnostics) as well as known biological properties of the fibrils.
Open Access zu Open Educational Resources - ein Bericht aus Österreich
Creators: name: Hackl, Claudia
Publisher: name: Zenodo
Year: 2022
Subjects: Open Access
Open Educational Resources

description: Analog zu institutionell bereits verankerten Aktivitäten im Bereich Open Access in der Forschung, beginnen sich OER an Hochschulen zu etablieren und stoßen bei Lehrenden, Studierenden und Leitungsebenen auf zunehmendes Interesse. Diese „educational skills“ im Bereich der OER sind ebenso in der EU Open Science Policy als eine der zentralen „ambitions“, die Forscher*innen beim Praktizieren von Open Science benötigen, verankert (European Comission, 2019). Neben dem Kompetenzaufbau zur Verwendung und Erstellung von OER ist deren Verfügbarkeit und Auffindbarkeit von zentraler Bedeutung, um die Akzeptanz von OER nachhaltig zu sichern. Somit besteht die Anforderung seitens der Nachhaltigkeit neben Publikationen und Forschungsdaten, immer öfter auch Inhalte aus der Lehre langfristig verfügbar zu machen. In diesem Open Access Talk wurden Synergien zwischen Open Science und Open Education im Rahmen der aktuellen Open Educational Resources (OER)-Aktivitäten in Österreich vorgestellt - mit dem Fokus auf „Open Education Austria Advanced“, das als Projekt österreichischer Universitäten eine vielschichtige nationale Infrastruktur für OER als Gesamtprojektziel verfolgt. Ebenso wurden Anforderungen an die im Projekt verfolgte Schnittstellenarbeit zwischen E-Learning-Zentren, Zentralen IT-Services und Bibliotheken diskutiert. Die Präsentation wurde im Rahmen der Webinar-Reihe Open Access Talk des BMBF-geförderten Projektes open-access.network am 27.01.2022 gehalten.
Con Starlink internet per tutti. Ma a che prezzo?
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2019

SpaceX ha immesso in orbita i primi 60 satelliti di Starlink, una piccola parte dei 12mila programmati per la copertura internet a banda larga su scala planetaria, prevista per il 2027. Ma se da una parte questo sembra essere un beneficio per l’umanità, gli scienziati che studiano il cielo con i radiotelescopi hanno motivo di preoccuparsi
Ecco come strappare a forza ossigeno alla CO2
Creators: Eliana Lacorte
Publisher: name: Media Inaf
Year: 2019

La forza cinetica d’un impatto può essere sufficiente a estrarre ossigeno molecolare dall’anidride carbonica. Il processo, già osservato per le molecole d’acqua attorno alle comete, è ora stato replicato in laboratorio, ponendo le basi per future applicazioni per missioni spaziali o per la mitigazione dell’effetto serra
Effects of postoperative physical exercise rehabilitation on cardiorespiratory fitness, functional capacity and quality of life in patients with colorectal, breast, and prostate cancer : a systematic review and meta-analysis
Creators: name: Beyer, Mailin
name: Bischoff, Christian
name: Lässing, Johannes
name: Gockel, Ines
name: Falz, Roberto
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2025
Subjects: subject: 610

description: Purpose: The reduced cardiorespiratory fitness (CRF) and functional capacity following surgical procedures and during cancer treatments is a major risk factor for morbidity and mortality among patients with cancer. We aimed to assess the impact of endurance and combined resistance exercise interventions during the postoperative rehabilitation period for patients with colorectal, breast, and prostate cancer. Methods: A systematic search was conducted in MEDLINE Pubmed, Web of Science, and Cochrane Library until October 2023 for randomized controlled trials that assessed exercise interventions (aerobic/endurance; resistance or combined training) on postoperative patients with cancer. The trials evaluated the change in oxygen uptake (VO2max), six-minute walking distance (6MWD), quality of life (QoL), and fatigue. Results: Twelve studies, including 1298 patients, were part of this systematic review, and ten studies were included in the meta-analysis. Postoperative exercise interventions led to improvements in CRF and functional capacity (VO2max: MD 1.46 ml/kg/min; 95%-CI 0.33, 2.58; p  = 0.01; 6MWD: MD 63.47 m; 95%-CI 28.18, 98.76; p = 0.0004, respectively) as well as QoL (0.91; 95%-CI 0.06, 1.76; p = 0.04). The quality of evidence was moderate to low. Conclusion: Postoperative exercise interventions could effectively improve CRF, functional capacity and QoL as shown in this meta-analysis. However, there is a lack of high-quality trials with a higher number of participants examining the effects of postoperative exercise in patients with colorectal, breast, and prostate cancer. There is an obvious need for long-term, cancer-specific exercise therapies and their evaluation in cancer care.
Quark number susceptibility around the critical end point
Creators: name: He, Min
name: Li, Jian-Feng
name: Sun, Wei-Min
name: Zong, Hong-Shi
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The quark number susceptibility is expressed as an integral in terms of dressed quark propagator and dressed vector vertex. It is then investigated with the latter two- and three-point functions confronted with a Dyson-Schwinger equation model which accommodates both finite temperature and baryon chemical potential. The critical end point in the phase diagram is identified and the behavior of the quark number susceptibility around the critical end point is highlighted. The characteristic features found agree well with recent lattice QCD simulation results.
description: 14 pages, 4 figures, revtex4, A discussion on the sensitivity of the results with respect to the variation of parameters and a new figure added