cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bosons with long range interactions on two-leg ladders in artificial magnetic fields
Creators: name: Natu, Stefan S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Motivated by experiments exploring the physics of neutral atoms in artificial magnetic fields, we study the ground state of bosons interacting with long range dipolar interactions on a two-leg ladder. Using two complimentary variational approaches, valid for weak interactions, we find rich physics driven by the long range forces. Generically, long range interactions tend to destroy the Meissner phase in favor of modulated density wave phases. Nearest neighbor interactions produce a novel interleg charge density wave phase, where the total density remains uniform, but the density on each leg of the ladder is modulating in space, out-of-phase with one another. At weak magnetic fields, next nearest neighbor interactions lead to a fully modulated biased ladder phase, where all the particles are on one leg of the ladder, and the density is modulating in space. This state simultaneously breaks $Z_{2}$ reflection symmetry and $U(1)$ symmetry associated with translation in real space. For values of the flux near $ϕ= π$, we find that a switching effect occurs for arbitrarily weak interactions, where the density modulates in space, but the chiral current changes sign on every plaquette. Arbitrarily weak attractive interactions along the rungs destroy the Meissner phase completely, in favor of a modulated density wave phase. Varying magnetic field produces a cascade of first order transitions between modulated density wave states with different wave-vectors, which manifests itself as discrete jumps in the chiral current. Polarizing the dipoles along the ladder direction yields a region of phase space where a stable biased ladder phase occurs even at arbitrarily weak magnetic fields. We discuss the experimental consequences of our work, in particular, how the interleg charge density wave can manifest itself in recent experiments on bosons in synthetic dimensions.
description: 12 pages, 4 figures
title: Prospective follow-up of patients with B3 lesions over a 4-year period
Creators: name: Forester, Nerys
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Mammography
subject: Ultrasound
subject: Biopsy
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: B3 breast lesions are a group of diverse breast lesions. It is an umbrella term to describe a family of lesions, which include papilloma, radial scars, Atypical Ductal Hyperplasia (ADH and AIDP), Flat Epithelial Atypia (FEA) and Lobular Neoplasia...
title: Localisation of the epileptogenic neural network by the resting state fMRI in patients with temporal lobe epilepsy
Creators: name: Omelchenko, Oleksii
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: MR-Functional imaging
subject: Neural networks
subject: Physiological studies
subject: Seizure disorders

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Epilepsy is a chronic neurological disorder characterised by the recurrent seizures and it occurs in over 0.5% of the world population. Temporal lobe epilepsy (TLE) accounts for more than a half of cases in the epilepsy cohort. Usually, TLE exhibits...
title: Automatic exposure control systems with inappropriate topogram: a phantom study in chest ct on radiation dose and image quality.
Creators: name: Park, Guan Jung
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Radiation safety
subject: CT-High Resolution
subject: CT-Angiography
subject: CT
subject: Thorax
subject: Radioprotection / Radiation dose
subject: Biological effects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of this study is to investigate the change of radiation dose and image quality in outside topogram of scan range applying automatic exposure control (AEC) through phantom study in chest...
(103382) Gertrude Louisa Perham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Generation of Ultra-intense Gamma-ray Train by QED Harmonics
Creators: name: Liu, Chen
name: Shen, Baifei
name: Zhang, Xiaomei
name: Ji, Liangliang
name: Wang, Wenpeng
name: Xu, Jiancai
name: Zhao, Xueyan
name: Yi, Longqing
name: Shi, Yin
name: Zhang, Lingang
name: Xu, Tongjun
name: Pei, Zhikun
name: Xu, Zhizhan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: When laser intensity exceeds 10^22W/cm^2, photons with energy above MeV can be generated from high-order harmonics process in the laser-plasma interaction. We find that under such laser intensity, QED effect plays a dominating role in the radiation pattern. Contrast to the gas and relativistic HHG processes, both the occurrence and energy of gamma-ray emission produced by QED harmonics are random and QED harmonics are usually not coherent, while the property of high intensity and ultra-short duration is conserved. Our simulation shows that the period of gamma-ray train is half of the laser period and the peak intensity is 1.4e22W/cm^2. This new harmonic production with QED effects are crucial to light-matter interaction in strong field and can be verified in experiments by 10PW laser facilities in the near future.
description: 12 pages, 4 figures
title: Pancreatic masses: Does diffusion weighted MR imaging add to contrast enhanced CT in their diagnosis and staging?
Creators: name:  Abd El-Rahman, Lamiaa
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Cancer
subject: Efficacy studies
subject: MR-Diffusion/Perfusion
subject: CT
subject: Pancreas
subject: Gastrointestinal tract
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of our study is to compare between diffusion weighted MRI (as a relatively recent modality) & contrast enhanced CT (as the standard protocol) regarding detection of pancreatic masses & proper staging to allow early detection of...
Study of cluster reconstruction and track fitting algorithms for CGEM-IT at BESIII
Creators: name: Guo, Yue
name: Wang, Liang-Liang
name: Ju, Xu-Dong
name: Wu, Ling-Hui
name: Xiu, Qing-Lei
name: Wang, Hai-Xia
name: Dong, Ming-Yi
name: Hu, Jing-Ran
name: Li, Wei-Dong
name: Li, Wei-Guo
name: Liu, Huai-Min
name: Ou-Yang, Qun
name: Shen, Xiao-Yan
name: Yuan, Ye
name: Zhang, Yao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Considering the aging effects of existing Inner Drift Chamber (IDC) of BES\uppercase\expandafter{\romannumeral3}, a GEM based inner tracker is proposed to be designed and constructed as an upgrade candidate for IDC. This paper introduces a full simulation package of CGEM-IT with a simplified digitization model, describes the development of the softwares for cluster reconstruction and track fitting algorithm based on Kalman filter method for CGEM-IT. Preliminary results from the reconstruction algorithms are obtained using a Monte Carlo sample of single muon events in CGEM-IT.
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace
Creators: name: Pasternak, G.W.
name: Uprety, R.
name: Xu, J.
name: Hunkele, A.
name: Majumdar, S.
name: Pan, Y.-X.
name: Baumann, M.H.
name: Roth, B.L.
name: Huang, X.P.
name: Le Rouzic, V.
Publisher: name: Elsevier Ltd
Year: 2018

description: Novel synthetic opioids (NSO) are increasingly encountered in illicit heroin and counterfeit pain pills. Many NSO are resurrected from older biomedical literature or patent applications, so limited information is available about their biological effects. Here we examined the pharmacology of three structurally-distinct NSO found in the recreational drug market: N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylbutyramide (butyrylfentanyl), 3,4-dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (MT-45). Radioligand binding and GTPγS functional assays were carried out in cells transfected with murine mu- (MOR-1), delta- (DOR-1) or kappa-opioid receptors (KOR-1). Antinociceptive effects were determined using the radiant heat tail flick technique in mice, and opioid specificity was assessed with the mu-opioid antagonist naloxone. Butyrylfentanyl, U-47700 and MT-45 displayed nM affinities at MOR-1, but were less potent than morphine, and had much weaker effects at DOR-1 and KOR-1. All NSO exhibited agonist actions at MOR-1 in the GTPγS assay. Butyrylfentanyl and U-47700 were 31- and 12-fold more potent than morphine in the tail flick assay, whereas MT-45 was equipotent with morphine. Analgesic effects were reversed by naloxone and absent in genetically-engineered mice lacking MOR-1. Our findings confirm that butyrylfentanyl, U-47700 and MT-45 are selective MOR-1 agonists with in vitro affinities less than morphine. However, analgesic potencies vary more than 30-fold across the compounds, and in vitro binding affinity does not predict in vivo potency. Taken together, our findings highlight the risks to humans who may unknowingly be exposed to these and other NSO when taking adulterated heroin or counterfeit pain medications. This article is part of the Special Issue entitled ‘Designer Drugs and Legal Highs.’ © 2017
(103384) Ethel Mary Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
Creators: name: Jensen, A.A.
name: Popov, P.
name: Pu, M.
name: Hanson, M.A.
name: Huang, X.-P.
name: Zhao, S.
name: Gloriam, D.E.
name: Liu, Z.-J.
name: Qu, L.
name: Harpsøe, K.
name: Ding, K.
name: Lansu, K.
name: Roth, B.L.
name: Nikolajsen, L.F.
name: Bjørn-Yoshimoto, W.E.
name: Wu, Y.
name: McCorvy, J.D.
name: Yuan, S.
name: Stevens, R.C.
name: Han, G.W.
name: Shen, L.
name: Cheng, J.
name: Che, T.
name: Katritch, V.
name: Peng, Y.
name: Wacker, D.
Publisher: name: Cell Press
Year: 2018

description: Drugs frequently require interactions with multiple targets—via a process known as polypharmacology—to achieve their therapeutic actions. Currently, drugs targeting several serotonin receptors, including the 5-HT2C receptor, are useful for treating obesity, drug abuse, and schizophrenia. The competing challenges of developing selective 5-HT2C receptor ligands or creating drugs with a defined polypharmacological profile, especially aimed at G protein-coupled receptors (GPCRs), remain extremely difficult. Here, we solved two structures of the 5-HT2C receptor in complex with the highly promiscuous agonist ergotamine and the 5-HT2A-C receptor-selective inverse agonist ritanserin at resolutions of 3.0 Å and 2.7 Å, respectively. We analyzed their respective binding poses to provide mechanistic insights into their receptor recognition and opposing pharmacological actions. This study investigates the structural basis of polypharmacology at canonical GPCRs and illustrates how understanding characteristic patterns of ligand-receptor interaction and activation may ultimately facilitate drug design at multiple GPCRs. Understanding how one drug can bind to many similar targets and have different functional outcomes will inform drug design with desired efficacy profiles. © 2018 Elsevier Inc.
Examenul CT de craniu©Zaharia Tudorel ISSN 00000XXXXX.pdf
Creators: name: Zaharia, Tudorel
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 320222
subject: Radiology and organ imaging
classificationCode: 399999
subject: Other education not elsewhere classified

description: Acest eseu de imagistică se referă la o examinare prin tomografie computerizată a creierului și a structurilor craniene înconjurătoare .Acesta este cel mai frecvent efectuat ca un studiu non-contrast, dar adăugarea unei faze îmbunătățite cu contrast se efectuează pentru unele indicații. Materialul de față poate fi util atât elevilor cât și profesioniștilor .
Towards an ecocritical community music practice
Creators: name: McNally, Kevin
Publisher: name: University of Limerick
Year: 2023
Subjects: Music

description: This thesis documents my research journey to develop an ecocritical community music practice, combining an academic exploration of ecocriticism with an arts practice investigation of my work as the facilitator of a community gamelan ensemble in County Cork, Ireland. My focus is on the human experiences of interconnection that occur via musicking, and I link those experiences to the interconnection of all beings in the biosphere. The interconnection and interdependence of everything in an ecosystem or a biosphere can be known as a rational fact, but because modern human life insulates us from the consequences of our activities, we don’t feel like we are affecting and are affected by the nonhuman entities around us. Indeed, most of the time these nonhuman entities – microplastics, kelp forests, carbon atoms in the atmosphere – are effectively invisible to us. I always knew that musicking was an expression of interdependence with other musicians, and as I followed a path through ecocritical literature, I realised that that there is a much more profound and far-reaching form of interdependence happening between bodies, sounds and spaces than I first thought. That sonic interdependence is a model for feeling the truth of the evolutionary feedback loop that co-constructs organism and environment, and, therefore, musicking is way of generating an affective atmosphere in which we can learn to care – truly care – for the entities that surround and sustain us. The theoretical basis for my research links contemporary ecocriticism and affect theory with ethnomusicology, ecomusicology and community music studies, finding resonances across those disciplines. I use a mixed-methods approach to document the practice via autoethnography, audio-visual material, focus groups and questionnaires. Two major pillars in the research journey are the two doctoral performances that are both research outputs and intrinsic methods for interrogating the topic. The first is presented as a duet between a solo human performer and a gong, and it is an exploration of the agency of nonhuman material, inspired by posthuman and ecocritical literature. The second is a series of ‘field trips’ in which the gamelan orchestra uses sound to probe the affective atmospheres generated by playing in different performances spaces. This thesis lays bare the process of rebuilding my community music practice along ecocritical lines, and finds that much of it has to do with the curation of affective atmospheres, to which participants actively tune.
title: Ultrasound diagnostics of priapism
Creators: name: Gromov, Alexander
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Emergency
subject: Genital / Reproductive system male
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Power Doppler
subject: Intraoperative
subject: Arteriovenous malformations
subject: Fistula
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Introduction. Pathological condition characterized by persistent and painful erection lasting more than 4 hours and not related to sexual arousal and do not respond during intercourse is called priapism [1, 2]. In clinical practice, priapism is...
Comparison of renormalized interactions using one-dimensional few-body systems as a testbed
Creators: name: Brauneis, Fabian
name: Hammer, Hans-Werner
name: Reimann, Stephanie M.
name: Volosniev, Artem G.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Even though the one-dimensional contact interaction requires no regularization, renormalization methods have been shown to improve the convergence of numerical ab initio calculations considerably. In this work, we compare and contrast these methods: `the running coupling constant' where the two-body ground state energy is used as a renormalization condition, and two effective interaction approaches that include information about the ground as well as excited states. In particular, we calculate the energies and densities of few-fermion systems in a harmonic oscillator with the configuration interaction method, and compare the results based upon renormalized and bare interactions. We find that the use of the running coupling constant instead of the bare interaction improves convergence significantly. A comparison with an effective interaction, which is designed to reproduce the relative part of the energy spectrum of two particles, showed a similar improvement. The effective interaction provides an additional improvement if the center-of-mass excitations are included in the construction. Finally, we discuss the transformation of observables alongside the renormalization of the potential, and demonstrate that this might be an essential ingredient for accurate numerical calculations.
description: Version accepted for publication in Phys. Rev. A
MUDANÇA CULTURAL E O COMPORTAMENTO DE SAÚDE DAS MINORIAS ÉTNICAS: UMA TEORIA OPERANTE DE ACULTURAÇÃO
Creators: name: De Melo Queiroz, Ana Emilia
name: De Andrade, Luciana Dantas Farias
name: Silva, Susanne Pinheiro Costa E
Publisher: name: Zenodo
Year: 2023

description: Apresentação de disciplina
Associations between Antibiotic Use and Resistance in Mahasarakham Hospital
Creators: name: Chutimaporn Chaiyasong
Publisher: name: Faculty of Pharmaceutical Sciences KKU  MSU  UBU
Year: 2019
Subjects: antibiotics
antibiotic use
antibiotic resistance
antimicrobial resistance

description: Isan Journal of Pharmaceutical Sciences, 15, 2, 98-105
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Creators: name: Zaidi, S.A.
name: Krumm, B.E.
name: Uprety, R.
name: Pasternak, G.W.
name: McCorvy, J.D.
name: Han, G.W.
name: Wang, S.
name: Carroll, F.I.
name: Vardy, E.
name: Tribo, A.R.
name: Strachan, R.T.
name: Stevens, R.C.
name: Roth, B.L.
name: Lee, M.-Y.
name: Huang, X.-P.
name: Wacker, D.
name: Che, T.
name: Katritch, V.
name: Majumdar, S.
name: Ondachi, P.
name: Mosier, P.D.
name: Cherezov, V.
name: Pardon, E.
name: Steyaert, J.
Publisher: name: Cell Press
Year: 2018

description: The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric, and analgesic activities. The design of KOP analgesics devoid of hallucinatory and dysphoric effects has been hindered by an incomplete structural and mechanistic understanding of KOP agonist actions. Here, we provide a crystal structure of human KOP in complex with the potent epoxymorphinan opioid agonist MP1104 and an active-state-stabilizing nanobody. Comparisons between inactive- and active-state opioid receptor structures reveal substantial conformational changes in the binding pocket and intracellular and extracellular regions. Extensive structural analysis and experimental validation illuminate key residues that propagate larger-scale structural rearrangements and transducer binding that, collectively, elucidate the structural determinants of KOP pharmacology, function, and biased signaling. These molecular insights promise to accelerate the structure-guided design of safer and more effective κ-opioid receptor therapeutics. A crystal structure of the active κ-opioid receptor provides a guide for the development of safe and effective new analgesics. © 2017 Elsevier Inc.
(103385) Arthur Reginald Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Utilizing a Systematic Approach in Screening for Congenital Heart Defects
Creators: name: El Helou, Nabil
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Foetus
subject: Education and training
subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Foetal imaging
subject: Cardiac
subject: Anatomy
subject: Obstetrics

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recognize the normal sonographic appearance of the fetal heart. Review the five axial views recommended by the ISUOG to rapidly screen for congenital heart defects (CHD). Review the congenital heart defects most commonly encountered in daily...
Far away from the lamppost
Creators: name: Schürer, S.
name: Jan, L.
name: McManus, M.T.
name: Johnson, G.L.
name: Roth, B.L.
name: Ma’ayan, A.
name: Oprea, T.I.
name: Shoichet, B.K.
name: Sklar, L.A.
Publisher: name: Public Library of Science
Year: 2018

description: [No abstract available]
title: Evaluation of the role of Magnetic Resonance Imaging (MRI) in Spinal Trauma Patients.
Creators: name: Magu, Sarita
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Outcomes analysis
subject: MR
subject: Neuroradiology spine
subject: Emergency
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To Evaluate the role of Magnetic Resonance Imaging in Spinal Trauma Patients and to compare MR findings with clinical profile and neurological status of the patient. To correlate the MR findings with neurological recovery of the patient and...
Direct Visualization of Memory Effects in Artificial Spin Ice
Creators: name: Gilbert, Ian
name: Chern, Gia-Wei
name: Fore, Bryce
name: Lao, Yuyang
name: Zhang, Sheng
name: Nisoli, Cristiano
name: Schiffer, Peter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We experimentally demonstrate that arrays of interacting nanoscale ferromagnetic islands, known as artificial spin ice, develop reproducible microstates upon cycling an applied magnetic field. The onset of this memory effect is determined by the strength of the applied field relative to the array coercivity. Specifically, when the applied field strength is almost exactly equal to the array coercivity, several training cycles are required before the array achieves a nearly completely repeatable microstate, whereas when the applied field strength is stronger or weaker than the array coercivity, a repeatable microstate is achieved after the first minor loop. We show through experiment and simulation that this memory exhibited by artificial spin ice is due to a ratchet effect on interacting, magnetically-charged defects in the island moment configuration and to the complexity of the network of strings of reversed moments that forms during magnetization reversal.
description: 19 pages, 8 figures
A Study of Differences in Ease of Accusing Gender Stereotypes in Same- and Opposite-Gender Relationships
Creators: name: Majima, Yoshimasa
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social Psychology
subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: For the purposes of this study, we define "accusation" as the act of pointing out that the other party's statement is problematic and making it widely known when both men and women are exposed to hostile gender discrimination through statements based on gender stereotypes. Participants are then presented with scenario tasks in which they encounter gender stereotype-based statements in three different domains: the home/community domain, the workplace domain, and the school domain. Subsequently, we assess the extent to which these statements trigger negative emotions. Building upon previous research, our hypothesis is that exposure to hostile gender discrimination increases negative emotions and the inclination to engage in gender-related collective action, thereby rendering individuals more likely to "blow the whistle." Furthermore, participants are presented with a scenario in which they observe a third party subjected to discriminatory speech based on gender stereotyping. We will examine whether the intensity of negative emotions and the ease of making an "accusation" differ when the person in the scenario shares the same gender as the participant or has the opposite gender. We expect that people are more likely to accuse others of making gender-stereotypical statements to the same gender than to the opposite gender.
Beyond the Hubbard bands in strongly correlated lattice bosons
Creators: name: Strand, Hugo U. R.
name: Eckstein, Martin
name: Werner, Philipp
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate features in the single-particle spectral function beyond the Hubbard bands in the strongly correlated normal phase of the Bose-Hubbard model. There are two distinct classes of additional peaks generated by the bosonic statistics. The first type is thermally activated Hubbard "sidebands", with the same physical origin as the zero-temperature Hubbard bands, but generated by excitations from thermally activated local occupation number states. The second class are two-particle fluctuation resonances driven by the lattice dynamics. In the unity filling Mott insulator, this takes the form of a localized triplon combined with a dispersing holon. Both types of resonances also manifest themselves in the structure factor and the interaction modulation spectra obtained from nonequilibrium bosonic dynamical mean-field theory calculations. Our findings explain experimental lattice modulation and Bragg spectroscopy results, and they predict a strong temperature dependence of the first sideband, thereby opening the door to precise thermometry of strongly correlated lattice bosons.
description: 9 pages, 3 figures, including appendices
Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
Creators: name: Kormos, B.L.
name: Dror, R.O.
name: Shoichet, B.K.
name: Rechsteiner, K.
name: Kelly, B.
name: McCorvy, J.D.
name: Roth, B.L.
name: Jin, J.
name: Butler, K.V.
name: Betz, R.M.
name: Karpiak, J.
Publisher: name: Nature Publishing Group
Year: 2018

description: Development of biased ligands targeting G protein-coupled receptors (GPCRs) is a promising approach for current drug discovery. Although structure-based drug design of biased agonists remains challenging even with an abundance of GPCR crystal structures, we present an approach for translating GPCR structural data into β-arrestin-biased ligands for aminergic GPCRs. We identified specific amino acid-ligand contacts at transmembrane helix 5 (TM5) and extracellular loop 2 (EL2) responsible for Gi/o and β-arrestin signaling, respectively, and targeted those residues to develop biased ligands. For these ligands, we found that bias is conserved at other aminergic GPCRs that retain similar residues at TM5 and EL2. Our approach provides a template for generating arrestin-biased ligands by modifying predicted ligand interactions that block TM5 interactions and promote EL2 interactions. This strategy may facilitate the structure-guided design of arrestin-biased ligands at other GPCRs, including polypharmacological biased ligands.
title: Emergency Endovascular Treatment in Splenic Artery Pseudoaneurym
Creators: name: Aydın, Elçin
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Arteries / Aorta
subject: Interventional vascular
subject: Catheter arteriography
subject: Arterial access
subject: Stents
subject: Haemorrhage
subject: Trauma

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Although splenic artery pseudoaneuryms (SAPA) are rare cause of acute abdomen, when they rupture they have high mortality rates. Posttraumatic splenic artery injury and/or active bleeding have also high mortality rates and they require immediate...
Effectiveness of Promote Rational Use of Antibiotics in sub-district health promoting hospitals case Nakornrajsima province
Creators: name: Phisit Khongsaktrakun
Publisher: name: Faculty of Pharmaceutical Sciences KKU  MSU  UBU
Year: 2019
Subjects: antibiotics
rational use of drugs
acute gastroenteritis
upper respiratory tract infections

description: Isan Journal of Pharmaceutical Sciences, 15, 2, 106-117
Effects of rifampicin on the expressions of drug transporter OATP1B1, drug metabolizing enzymes CYP3A4 and CYP3A5, and nuclear receptors PXR and AhR in human HepG2 and BeWo cells
Creators: name: Thongtham Suksawat
Publisher: name: Faculty of Pharmaceutical Sciences KKU  MSU  UBU
Year: 2019
Subjects: rifampicin
hepatocellular carcinoma
choriocarcinoma
cytochrome P450
drug transporter
nuclear receptor

description: Isan Journal of Pharmaceutical Sciences, 15, 2, 118-128
High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening
Creators: name: Shui, W.
name: Lu, Y.
name: Zhou, Q.
name: Song, G.
name: McCorvy, J.D.
name: Meng, M.
name: Qin, S.
name: Hanson, M.A.
name: Cai, X.
name: Yang, D.
name: Stevens, R.C.
name: Wu, Y.
name: Peng, Y.
name: Huang, X.
name: Dai, A.
name: Bai, W.
name: Wang, M.-W.
name: Liu, Z.-J.
name: Zhao, S.
name: Roth, B.L.
Publisher: name: Royal Society of Chemistry
Year: 2018

description: G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins and thus constitute an important family of therapeutic targets. Therefore, significant effort has been put towards the identification of novel ligands that can modulate the activity of a GPCR target with high efficacy and selectivity. However, due to limitations inherent to the most common techniques for GPCR ligand discovery, there is a pressing need for more efficient and effective ligand screening methods especially for the identification of potential allosteric modulators. Here we present a high-throughput, label-free and unbiased screening approach for the identification of small molecule ligands towards GPCR targets based on affinity mass spectrometry. This new approach features the usage of target-expressing cell membranes rather than purified proteins for ligand screening and allows the detection of both orthosteric and allosteric ligands targeting specific GPCRs. Screening a small compound library with this approach led to the rapid discovery of an antagonist for the 5-HT receptor and four positive allosteric modulators for GLP-1 receptor that were not previously reported. © 2018 The Royal Society of Chemistry.
Stability of the Standard Model Vacuum with Vector-Like Leptons: A Critical Examination
Creators: name: Cingiloglu, Kivanc Y.
name: Frank, Mariana
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The stability of the Standard Model (SM) Higgs vacuum is a long-standing issue in particle physics. The SM Higgs quartic coupling parameter is expected to become negative at high scales, potentially generating an unstable vacuum well before reaching the Planck scale. We investigate whether the introduction of vector-like leptons (VLLs) in six distinct gauge anomaly-independent representations can stabilize the SM vacuum without introducing additional scalar fields. By analyzing the mass spectrum and mixing angles of these VLLs with the SM leptons, we identify conditions under which the Higgs potential remains stable. We demonstrate that there exists a set of allowed but narrowed VLL spectra that can indeed stabilize the SM vacuum. We also study the effect of these VLLs on electroweak precision observables, particularly the oblique parameters S and T to ensure fit within global experimental constraints. Finally, we perform a comprehensive analysis of the parameter space allowed by electroweak precision data and the parameter space required for stability, highlighting cases that accommodate both. This study opens up new avenues for understanding the role of vector-like leptons in extending the validity of the Standard Model up to the Planck scale.
description: 26 pages, 10 figures
title: MDCT in evaluation of additional volume of insufflated CO2 for preoperative progressive pneumoperitoneum in patients with large and giant ventral hernias.
Creators: name: Petrenko, Dmytro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Outcomes
subject: Hernia
subject: Contrast agent-oral
subject: Contrast agent-intravenous
subject: Catheters
subject: CT
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Large and giant ventral hernias (VH) still considered a problem both for surgeons and radiologists. Multidetector computed tomography (MDCT) remains a method of choice in diagnostics of large and giant ventral hernias in preoperative period before...
The American COVID-19 Vaccine Poll
Creators: name: African American Research Collaborative
name: Commonwealth Fund
name: Foundation, Robert Wood Johnson
name: W.K. Kellogg Foundation
Publisher: name: Roper Center for Public Opinion Research
Year: 2023

description: Flu vaccine (3); have gotten/intend to get coronavirus (COVID-19) vaccine (14); concerns about COVID-19 vaccine (1); safety of COVID-19 vaccines (8); racial disparities in COVID-19 outcomes (1); geographic healthcare inequity (1); racial/ethnic bias in healthcare (5); intended practice to reduce COVID-19 risk (5); self/family member/friend contracted COVID-19 (5); tested positive for COVID-19 with or without symptoms (4); medical care for COVID-19 (2); know someone who has died from COVID-19 (4); concern about contracting COVID-19 (1); annual COVOID-19 vaccination (1); combination COVID-19-Flu vaccine (1); effect of 2020 election on desire to be vaccinated for COVID-19 (1); effect of the COVID-19 pandemic on employment and health insurance (6); mental health over the past two weeks (4); access to COVID-19 vaccine (13); mandatory vaccinations (4); incentives to vaccination (2); preferred location for getting vaccinated (16); messaging effects on likelihood of getting COVID-19 vaccine (56); vaccination rate that reduces concern about getting vaccinated (6); COVID-19 booster shots (2); ease of getting COVID-19 vaccination (1); comfortable sharing vaccination status with friends/family (1); trust in government offices and officials/ health professionals/public figures/media about vaccine information (35); use of information/news channels (23); COVID-19 vaccinations for children (17); routine childhood vaccinations (2); support/oppose proposals to help students catch up academically after the pandemic (8); importance of racial identity (1); racial discrimination in the US today (1).
The Optimal Sample Complexity of PAC Learning
Creators: name: Hanneke, Steve
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: This work establishes a new upper bound on the number of samples sufficient for PAC learning in the realizable case. The bound matches known lower bounds up to numerical constant factors. This solves a long-standing open problem on the sample complexity of PAC learning. The technique and analysis build on a recent breakthrough by Hans Simon.
(103383) Helen Mary Scott
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Allergic contact dermatitis testing of resin of Dipterocarpus alatus Roxb. ex G. Don on human skin in healthy volunteers
Creators: name: Jutalak Phinit
Publisher: name: Faculty of Pharmaceutical Sciences KKU  MSU  UBU
Year: 2019
Subjects: patch test
contact dermatitis
irritation
Resin of Dipterocarpus alatus Roxb. ex G. Don
Yang Na

description: Isan Journal of Pharmaceutical Sciences, 15, 2, 129-134
title: Comparison of Apparent Diffusion Coefficient Values Obtained by Turbo Spin-echo and Echo-planar Imaging Techniques : A Phantom Study
Creators: name: Maruyama, Hirotoshi
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Image registration
subject: Imaging sequences
subject: MR-Diffusion/Perfusion
subject: Radiographers
subject: MR physics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Images acquired by turbo spin-echo diffusion-weight imaging technique (TSE-DWI) show lesser distortion and susceptibility artifacts compared to those acquired byecho-planar imagingdiffusion-weight imagingtechnique (EPI-DWI). In a previous...
title: Chronic recurrent multifocal osteomyelitis: a case series.
Creators: name: Cuocolo, Renato
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Oedema
subject: Treatment effects
subject: MR
subject: Paediatric
subject: Musculoskeletal bone

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To illustrate a series of chronic recurrent multifocal osteomyelitis (CRMO) cases before and after medical therapy, highliting our findings and the correct management of such...
title: Evaluation of the branching pattern of the intrahepatic bile ducts using 3D balanced turbo-field-echo (BTFE) MR sequence: comparison with drip infusion cholangiography with CT (DIC-CT)
Creators: name: Ogawa, Masaki
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Anatomy
subject: Biliary Tract / Gallbladder
subject: CT
subject: MR
subject: Imaging sequences
subject: Technology assessment
subject: Normal variants
subject: Congenital
subject: Image verification

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Few studies showed the utility of 3D BTFE sequence evaluating the branching patterns of the bile ducts and PV, though the sequence was developed several years ago and 2D BTFE sequence has been performed as a part of MRCP protocol in many clinics....
Presentation at the 'EU Space Week 2022' on the GoldenEye project
Creators: name: Gutierres, Francisco
name: Matselyukh, Taras
Publisher: name: Zenodo
Year: 2023
Subjects: (FOS) Earth and related environmental sciences
Earth Observation Data (EOD)
Analysis Ready Data (ARD)
Artificial Intelligence (AI)
GOLDENAI platform
OptOSS CLI (OCLI)
GOLDENAI GUI
AI Knowledge Pack (AI KP)

description: Presentation at the EU Space Week 2022 (Prague, Czech Republic |3–6 October 2022) in the session related to "Raw Materials". Url: https://www.euspaceweek.eu/programme/03-10-2022/eu-space-user-consultation-platform-raw-materials
description: Description of the 'EU Space User Consultation Platform - Raw Materials': With the depletion of 'easy deposits' that haven't been developed yet, mining exploration projects explore the most remote parts of the globe, making manual surveys expensive and time consuming. The transition to renewable energy furthermore poses significant pressure on the supply side for critical raw materials like copper and lithium. EO/GNSS data and services are key for raw material resource exploration, operations, and post-closure environmental management. This session will focus on user needs, sector trends, and the available Copernicus services. Coordinator: Escalona Zorita, Eduard (Space Downstream Market Officer at EUSPA - EU Agency for the Space Programme).
(103378) Hamlyn Horwood Perham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Precise Distances for Main-Belt Asteroids in Only Two Nights
Creators: name: Heinze, Aren N.
name: Metchev, Stanimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present a method for calculating precise distances to asteroids using only two nights of data from a single location --- far too little for an orbit --- by exploiting the angular reflex motion of the asteroids due to Earth's axial rotation. We refer to this as the rotational reflex velocity method. While the concept is simple and well-known, it has not been previously exploited for surveys of main-belt asteroids. We offer a mathematical development, estimates of the errors of the approximation, and a demonstration using a sample of 197 asteroids observed for two nights with a small, 0.9-meter telescope. This demonstration used digital tracking to enhance detection sensitivity for faint asteroids, but our distance determination works with any detection method. Forty-eight asteroids in our sample had known orbits prior to our observations, and for these we demonstrate a mean fractional error of only 1.6% between the distances we calculate and those given in ephemerides from the Minor Planet Center. In contrast to our two-night results, distance determination by fitting approximate orbits requires observations spanning 7--10 nights. Once an asteroid's distance is known, its absolute magnitude and size (given a statistically-estimated albedo) may immediately be calculated. Our method will therefore greatly enhance the efficiency with which 4-meter and larger telescopes can probe the size distribution of small (e.g. 100 meter) main belt asteroids. This distribution remains poorly known, yet encodes information about the collisional evolution of the asteroid belt --- and hence the history of the Solar System.
description: 24 pages, 5 figures, accepted by the Astronomical Journal
Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo
Creators: name: Mangano, T.J.
name: Che, T.
name: Roth, B.L.
name: Pasternak, G.W.
name: Pan, Y.-X.
name: Huang, X.-P.
name: Le Rouzic, V.
name: Majumdar, S.
name: Cameron, M.D.
name: Baumann, M.H.
Publisher: name: NLM (Medline)
Year: 2017

description: W-18 (4-chloro-N-[1-[2-(4-nitrophenyl)ethyl]-2-piperidinylidene]-benzenesulfonamide) and W-15 (4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]-benzenesulfonamide) represent two emerging drugs of abuse chemically related to the potent opioid agonist fentanyl (N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide). Here, we describe the comprehensive pharmacological profiles of W-18 and W-15, as examination of their structural features predicted that they might lack opioid activity. We found W-18 and W-15 to be without detectible activity at μ, δ, κ, and nociception opioid receptors in a variety of assays. We also tested W-18 and W-15 for activity as allosteric modulators at opioid receptors and found them devoid of significant positive or negative allosteric modulatory activity. Comprehensive profiling at essentially all the druggable GPCRs in the human genome using the PRESTO-Tango platform revealed no significant activity. Weak activity at the sigma receptors and the peripheral benzodiazepine receptor was found for W-18 (Ki = 271 nM). W-18 showed no activity in either the radiant heat tail-flick or the writhing assays and also did not induce classical opioid behaviors. W-18 is extensively metabolized, but its metabolites also lack opioid activity. Thus, although W-18 and W-15 have been suggested to be potent opioid agonists, our results reveal no significant activity at these or other known targets for psychoactive drugs.