cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A candidate gene study of tardive dyskinesia in the CATIE schizophrenia trial
Creators: name: Scott Stroup, T.
name: Miller, Del D.
name: North, Kari E.
name: Sullivan, Patrick F.
name: Caroff, Stanley N.
name: Lieberman, Jeffrey A.
name: McEvoy, Joseph
name: Tsai, Huei Ting
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Tardive dyskinesia (TD) is a movement disorder characterized by involuntary oro-facial, limb, and truncal movements. As a genetic basis for inter-individual variation is assumed, there have been a sizeable number of candidate gene studies. All subjects met diagnostic criteria for schizophrenia and were randomized to receive antipsychotic medications as participants in the Clinical Antipsychotic Trials of Intervention Effectiveness project (CATIE). TD was assessed via the Abnormal Involuntary Movement Scale at regular intervals. Probable TD was defined as meeting Schooler–Kane criteria at any scheduled CATIE visit (207/710 subjects, 29.2%). A total of 128 candidate genes were studied in 710 subjects—2,580 SNPs in 118 candidate genes selected from the literature (e.g., dopamine, serotonin, glutamate, and GABA pathways) and composite genotypes for 10 drug-metabolizing enzymes. No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature.
Searching for Vector Dark Matter by Higgs Portal at the LHC
Creators: name: Chen, Chuan-Hung
name: Nomura, Takaaki
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A Higgs portal dark matter model for explaining the gamma-ray excess from the galactic center can be realized with the extension of local $SU(2)_X$ gauge symmetry with one quadruplet. Due to the residual $Z_3$ discrete symmetry of $SU(2)_X$, the new gauge bosons are the stable dark matter candidates. Due to the mixture of the standard model Higgs doublet and the introduced quadruplet, dark matter could annihilate into the standard model particles through the Higgs portal and new scalar portal. We study the discovery significance of the vector dark matter at the Large Hadron Collider. The involved parameters are consistent with the constraints from relic density and direct detection and with the data of the galactic center gamma-ray excess. With $\sqrt{s}=14$ TeV and luminosities of $100$ and $300$ fb$^{-1}$, we find that a discovery significance of $S/\sqrt{B}=5$ can be easily reached if the production of dark matter is through the invisible decays of the Higgs boson and a new scalar boson.
description: 24 pages, 8 figures, References added, version published in PRD
Interspecies genetics of eating disorder traits
Creators: name: Bulik, Cynthia M.
name: Kas, Martien J.H.
name: Kaye, Walter H.
name: Mathes, Wendy Foulds
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Family and twin studies have indicated that genetic factors play a role in the development of eating disorders, such as anorexia and bulimia nervosa, but novel views and tools may enhance the identification of neurobiological mechanisms underlying these conditions. Here we propose an integrative genetic approach to reveal novel biological substrates of eating disorder traits analogous in mouse and human. For example, comparable to behavioral hyperactivity that is observed in 40-80% of anorexia nervosa patients, inbred strains of mice with different genetic backgrounds are differentially susceptible to develop behavioral hyperactivity when food restricted. In addition, a list of characteristics that are relevant to eating disorders and approaches to their measurement in humans together with potential analogous rodent models has been generated. Interspecies genetics of neurobehavioral characteristics of eating disorders has the potential to open new roads to identify and functionally test genetic pathways that influence neurocircuits relevant for these heterogeneous psychiatric disorders.
(100731) Alphonse Billiyard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study
Creators: name: Vieten, Cassandra
name: Ehlers, Cindy L.
name: Gizer, Ian R.
name: Wilhelmsen, Kirk C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Cannabis is the most widely used illicit drug in the United States. There is ample evidence that cannabis use has a heritable component, yet the genes underlying cannabis use disorders are yet to be completely identified. This study's aims were to map susceptibility loci for cannabis use and dependence and two narrower cannabis-related phenotypes of “craving” and “withdrawal” using a family study design. Participants were 2524 adults participating in the University of California San Francisco (UCSF) Family Alcoholism Study. DSM-IV diagnoses of cannabis dependence, as well as indices of cannabis craving and withdrawal, were obtained using a modified version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Genotypes were determined for a panel of 791 microsatellite polymorphisms. Multipoint variance component LOD scores were obtained using SOLAR. Genome-wide significance for linkage (LOD > 3.0) was not found for the DSM-IV cannabis dependence diagnosis, however, linkage analyses of cannabis “craving” and the cannabis withdrawal symptom of “nervous, tense, restless or irritable” revealed five sites with LOD scores over 3.0 on chromosomes 1, 3, 6, 7, 9. These results identify new regions of the genome associated with cannabis use phenotypes as well as corroborate the importance of several chromosome regions highlighted in previous linkage analyses for other substance dependence phenotypes.
Two Studies in Representation of Signals
Creators: name: CECINI, ENRICO
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The thesis consists of two parts. In the first part deals with a multi-scale approach to vector quantization. An algorithm, dubbed reconstruction trees, is proposed and analyzed. Here the goal is parsimonious reconstruction of unsupervised data; the algorithm leverages a family of given partitions, to quickly explore the data in a coarse-to-fine multi-scale fashion. The main technical contribution is an analysis of the expected distortion achieved by the proposed algorithm, when the data are assumed to be sampled from a fixed unknown probability measure. Both asymptotic and finite sample results are provided, under suitable regularity assumptions on the probability measure. Special attention is devoted to the case in which the probability measure is supported on a smooth sub-manifold of the ambient space, and is absolutely continuous with respect to the Riemannian measure of it; in this case asymptotic optimal quantization is well understood and a benchmark for understanding the results is offered. The second part of the thesis deals with a novel approach to Graph Signal Processing which is based on Matroid Theory. Graph Signal Processing is the study of complex functions of the vertex set of a graph, based on the combinatorial Graph Laplacian operator of the underlying graph. This naturally gives raise to a linear operator, that to many regards resembles a Fourier transform, mirroring the graph domain into a frequency domain. On the one hand this structure asymptotically tends to mimic analysis on locally compact groups or manifolds, but on the other hand its discrete nature triggers a whole new scenario of algebraic phenomena. Hints towards making sense of this scenario are objects that already embody a discrete nature in continuous setting, such as measures with discrete support in time and frequency, also called Dirac combs. While these measures are key towards formulating sampling theorems and constructing wavelet frames in time-frequency Analysis, in the graph-frequency setting these boil down to distinguished combinatorial objects, the so called Circuits of a matroid, corresponding to the Fourier transform operator. In a particularly symmetric case, corresponding to Cayley graphs of finite abelian groups, the Dirac combs are proven to completely describe the so called lattice of cyclic flats, exhibiting the property of being atomistic, among other properties. This is a strikingly concise description of the matroid, that opens many questions concerning how this highly regular structure relaxes into more general instances. Lastly, a related problem concerning the combinatorial interplay between Fourier operator and its Spectrum is described, provided with some ideas towards its future development.
Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
Creators: name: Andrews, Gavin
name: Sullivan, Patrick F.
name: Montgomery, Grant W.
name: Middeldorp, Christel M.
name: Statham, Dixie J.
name: Van Berg, Mireille Den
name: Martin, Nicholas G.
name: Geus, Eco J.C.De
name: Wray, Naomi R.
name: Coventry, Will L.
name: Boomsma, Dorret I.
name: Hottenga, Jouke Jan
name: Slagboom, P. Eline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2.
Flexible Multi-layer Sparse Approximations of Matrices and Applications
Creators: name: Magoarou, Luc Le
name: Gribonval, Rémi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: The computational cost of many signal processing and machine learning techniques is often dominated by the cost of applying certain linear operators to high-dimensional vectors. This paper introduces an algorithm aimed at reducing the complexity of applying linear operators in high dimension by approximately factorizing the corresponding matrix into few sparse factors. The approach relies on recent advances in non-convex optimization. It is first explained and analyzed in details and then demonstrated experimentally on various problems including dictionary learning for image denoising, and the approximation of large matrices arising in inverse problems.
Searches for new physics with boosted top quarks in the MadAnalysis 5 and Rivet frameworks
Creators: name: Araz, Jack Y.
name: Buckley, Andy
name: Fuks, Benjamin
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: High-momentum top quarks are a natural physical system in collider experiments for testing models of new physics, and jet substructure methods are key both to exploiting their largest decay mode and to assuaging resolution difficulties as the boosted system becomes increasingly collimated in the detector. To be used in new-physics interpretation studies, it is crucial that related methods get implemented in analysis frameworks allowing for the reinterpretation of the results of the LHC such as MadAnalysis 5 and Rivet. We describe the implementation of the HEPTopTagger algorithm in these two frameworks, and we exemplify the usage of the resulting functionalities to explore the sensitivity of boosted top reconstruction performance to new physics contributions from the Standard Model Effective Field Theory. The results of this study lead to important conclusions about the implicit assumption of Standard-Model-like top-quark decays in associated collider analyses, and for the prospects to constrain the Standard Model Effective Field Theory via kinematic observables built from boosted semileptonic top-antitop events selected using HEPTopTagger.
description: 19 pages, 5 figures; version accepted by EPJC
title: Datenvielfalt im Data-Sharing - eine kooperative Aufgabe von Forschenden und Forschungsdatenzentrum
title: Diversity of Data and Data Sharing - A Cooperative Task for Researchers and Research Data Center
titleType: AlternativeTitle
Creators: name: Mozygemba, Kati
name: Kretzer, Susanne
Publisher: name: Universität Bremen
Year: 2020
Subjects: subject: Data Sharing
subject: Qualitative Daten
subject: qualitative research
subject: social sciences
subject: diversity of data
subject: Datenvielfalt
subject: Sekundärnutzung
subject: Nachnutzung
subject: Archivierung von Daten
subject: 50

description: Abstract: Im vorliegenden Beitrag widmen wir uns Aspekten der Datenvielfalt, die beim Teilen qualitativer Forschungsdaten (Data Sharing) von Bedeutung sind. Wir zeigen, dass die Vielfalt qualitativer Forschungsdaten eine professionelle Archivierung und Vorbereitung für das Data Sharing erfordert, welche angemessenen Standards folgt und gleichzeitig für die Spezifik des jeweiligen Primärprojektes offenbleibt. Der Beitrag gliedert sich in drei Teile. Im ersten Teil präsentieren wir Gründe für das steigende Interesse am Thema „Data Sharing“ und beschreiben die, wenn auch zögerliche, Entwicklung einer Kultur des Data Sharing qualitativer Daten in Deutschland mit ihren kritischen und befürwortenden Argumenten. Im zweiten Teil stellen wir das Forschungsdatenzentrum (FDZ) Qualiservice vor, um im dritten Teil an diesem Beispiel zu zeigen, welche Aspekte von Vielfalt bei der Archivierung und Vorbereitung für das Data Sharing von Bedeutung sind und wie sie in der Praxis berücksichtigt werden können, um die Nachnutzbarkeit qualitativer Forschungsdaten zu ermöglichen. Die Projektspezifik spielt dabei ebenso eine Rolle wie datenschutzrechtliche und forschungsethische Aspekte sowie Überlegungen zu einem FAIRen Data Sharing.
High sensitivity microwave detection using a magnetic tunnel junction in the absence of an external applied magnetic field
Creators: name: Gui, Y. S.
name: Xiao, Y.
name: Bai, L. H.
name: Hemour, S.
name: Zhao, Y. P.
name: Houssameddine, D.
name: Wu, K.
name: Guo, H.
name: Hu, C. -M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In the absence of any external applied magnetic field, we have found that a magnetic tunnel junction (MTJ) can produce a significant output direct voltage under microwave radiation at frequencies, which are far from the ferromagnetic resonance condition, and this voltage signal can be increase by at least an order of magnitude by applying a direct current bias. The enhancement of the microwave detection can be explained by the nonlinear resistance/conductance of the MTJs. Our estimation suggests that optimized MTJs should achieve sensitivities for non-resonant broadband microwave detection of about 5,000 mV/mW.
(100725) Grace Ethel Beedie Beck
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Erläuterungen zur Verwendung der von Qualiservice bereitgestellten Vorlagen für die informierte Einwilligung
title: Explanatory notes on the templates for informed consent provided by Qualiservice
titleType: AlternativeTitle
Creators: name: Kretzer, Susanne
name: Mozygemba, Kati
name: Heuer, Jan-Ocko
name: Huber, Elisabeth
Publisher: name: Universität Bremen
Year: 2020
Subjects: subject: Sozialforschung
subject: qualitative Forschungsdaten
subject: Datenverarbeitung
subject: Datenschutzrecht
subject: Informierte Einwilligung
subject: Einwilligungserklärung
subject: Mustervorlagen
subject: Handreichung
subject: 300

description: Das Forschungsdatenzentrum (FDZ) Qualiservice hat gemeinsam mit der Kanzlei MLS LEGAL GmbH – Rechtsanwalts- und Fachanwaltsgesellschaft (mls legal) rechtssichere Vorlagen für die informierte Einwilligung zur (qualitativen) sozialwissenschaftlichen Forschung erstellt, die auf der Qualiservice-Website (https://www.qualiservice.org/) heruntergeladen werden können. Mit diesen Vorlagen möchte Qualiservice Forschende in der Vorbereitung der unterschiedlichen Phasen der Datenverarbeitung in ihrem Forschungsprojekt, aber auch in der Vorbereitung einer geplanten Archivierung und Bereitstellung der Forschungsdaten für die wissenschaftliche Sekundärnutzung, unterstützen. Das vorliegende Arbeitspapier ergänzt diese Vorlagen für die informierte Einwilligung, indem sie grundlegende Bestimmungen für die Information und die Einwilligungserklärung der Forschungsteilnehmer*innen darstellt und die Qualiservice-Mustervorlagen erläutert, die Forschende an ihr konkretes Forschungsvorhaben anpassen können.
(100727) Mary Ann Bennett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bulk Landau Pole and Unitarity of Dual Conformal Field Theory
Creators: name: Sachs, Ivo
name: Vanhove, Pierre
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The singlet sector of the $O(N)$ $ϕ^4$-model in AdS$_4$ at large-$N$, gives rise to a dual conformal field theory on the conformal boundary of AdS$_4$, which is a deformation of the generalized free field. We identify and compute an AdS$_4$ three-point one-loop fish diagram that controls the exact large-$N$ dimensions and operator product coefficients (OPE) for all ``double trace'' operators as a function of the renormalized $ϕ^4$-couplings. We find that the space of $ϕ^4$-coupling is compact with a boundary at the bulk Landau pole. The dual CFT is unitary only in an interval of ${\it negative}$ couplings bounded by the Landau pole where the lowest OPE coefficient diverges.
description: 13 pages. 6 figures. v2: Expanded version: new title, expanded abstract, and details on the derivation of the main result. Results and conclusion unaltered. Version to appear in JHEP
Spectroscopic Studies of an Ultraluminous Supersoft X-Ray Source in M81
Creators: name: Bai, Yu
name: Liu, JiFeng
name: Wang, Song
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Ultraluminous supersoft X-ray sources (ULSs) exhibit supersoft X-ray spectra with blackbody temperatures below 0.1 keV and bolometric luminosities above 10$^{39}$ ergs s$^{-1}$. In this Letter, we report the first optical spectroscopic observations of a ULS in M81 using the LRIS spectrograph on the Keck I telescope. The detected Balmer emission lines show a mean intrinsic velocity dispersion of 400$\pm$80 km s$^{-1}$, which is consistent with that from an accretion disk. The spectral index of the continuum on the blue side is also consistent with the multi-color disk model. The H$_α$ emission line exhibits a velocity of $\sim$180 km s$^{-1}$ relative to the local stellar environment, suggesting that this ULS may be a halo system in M81 belonging to an old population. No significant shift is found for the H$_α$ emission line between two observations separated by four nights.
Association study of 182 candidate genes in anorexia nervosa
Creators: name: Via, Maria La
name: Mitchell, James E.
name: Kaplan, Allan S.
name: Berrettini, Wade H.
name: Bergen, Andrew W.
name: Sullivan, Patrick F.
name: Treasure, Janet
name: Klump, Kelly L.
name: Goldman, David
name: Root, Tammy L.
name: Crawford, Steve
name: Schork, Nicholas J.
name: Kaye, Walter H.
name: Johnson, Craig
name: Keel, Pamela K.
name: Magistretti, Pierre
name: Rotondo, Alessandro
name: Halmi, Katherine A.
name: Pinheiro, Andrea Poyastro
name: Crow, Scott
name: Bulik, Cynthia M.
name: Bloss, Cinnamon S.
name: Strober, Michael
name: Fichter, Manfred M.
name: Woodside, D. Blake
name: Brandt, Harry
name: Thornton, Laura M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results in the literature (182 candidate genes), brain expression, biological plausibility, and estrogen responsivity. We employed a case–control design that tested each SNP individually as well as haplotypes derived from these SNPs in 1,085 case individuals with AN diagnoses and 677 control individuals. We also performed separate association analyses using three increasingly restrictive case definitions for AN: all individuals with any subtype of AN (All AN: n = 1,085); individuals with AN with no binge eating behavior (AN with No Binge Eating: n = 687); and individuals with the restricting subtype of AN (Restricting AN: n = 421). After accounting for multiple comparisons, there were no statistically significant associations for any individual SNP or haplotype block with any definition of illness. These results underscore the importance of large samples to yield appropriate power to detect genotypic differences in individuals with AN and also motivate complementary approaches involving Genome-Wide Association (GWA) studies, Copy Number Variation (CNV) analyses, sequencing-based rare variant discovery assays, and pathway-based analysis in order to make up for deficiencies in traditional candidate gene approaches to AN.
L'anticorpo monoclonale Trastuzumab (Tz) modula il contenuto proteico delle Vescicole Extracellulari (EVs) rilasciate da cellule di carcinoma mammario ErbB2 positive
Creators: name: MARCONI, SILVIA
Publisher: name: Universit� degli studi di Genova
Year: 2021

description: Cancers overexpressing the ERBB2 oncogene are aggressive and associated with a poor prognosis. Trastuzumab is a ERBB2 specific recombinant antibody employed for the treatment of these diseases since it blocks ERBB2 signaling causing growth arrest and survival inhibition. While the effects of Trastuzumab on ERBB2 cancer cells are well known, those on the extracellular vesicles released from these cells are scarce. This study focused on ERBB2+ breast cancer cells and aimed to establish what type of EVs they release and whether Trastuzumab affects their morphology and molecular composition. To these aims, we performed immunoelectron microscopy, immunoblot, and high-resolution mass spectrometry analyses on EVs purified by differential centrifugation of culture supernatant. Here we show that EVs released from ERBB2+ breast cancer cells are polymorphic in size and appearance, and that ERBB2 is preferentially associated with large (120 nm) EVs. Moreover, we report that Tz induces the expression of a specific glycosylated 50 kDa isoform of the CD63 tetraspanin and modulates the expression of 51 EVs proteins, including TOP1. As these pro- teins are functionally associated with organelle organization, cytokinesis, and response to lipids, we suggest that Tz may influence these cellular processes in target cells at distant sites via modified EVs.
Bolli di fabbrica e iconografia della sigillata italica, tardo italica e delle lucerne romane come indicatori di rapporti commerciali tra il I ed il III sec.d.C.: il caso di Nora (CA).
Creators: name: PARODI, ANNA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Lo studio che si viene a presentare riguarda le classi ceramiche della TSI, TSTI e delle lucerne: per osservare ed avere una conferma riguardo i flussi commerciali che le vedono protagoniste di cambiamenti all?interno dell?economia romana ma al tempo stesso indicano una continuazione di forti rapporti economici instaurati e mantenuti fin dalle epoche precedenti. La Sardegna � sempre stata considerata tra le grandi isole del mare Mediterraneo, nota per i commerci che avvenivano lungo la costa e i numerosi approdi creando quindi condizioni favorevoli di navigazione anche durante il mare clausum. Ci� � dovuto all?esistenza di una corrente marina di superficie tutto intorno all?isola che agevola la navigazione; questa trova conferma nella localizzazione dei diversi centri portuali di cui si � osservata l?importanza tramite i ritrovamenti di TSI, TSTI e lucerne. Con la presenza dei navicularii sardi ad Ostia, dove nel Piazzale delle Corporazioni sono annoverati anche otto porti africani, si pu� affermare che i legami tra le zone del Mediterraneo di influenza punica siano state sempre molto forti facendo della Sardegna un approdo importante al centro delle rotte commerciali di antica e recente tradizione.
Coltivazione di Lactobacillus plantarum e Lactococcus lactis in mezzo a base di estratto di soia: studio della cinetica di acidificazione, della crescita cellulare, dell?attivit� antimicrobica e dello stress gastrointestinale in vitro = Cultivo de Lactobacillus plantarum e Lactococcus lactis em meio contendo extrato de soja: estudo da cin�tica de acidifica��o, do crescimento celular, da atividade antimicrobiana e do estresse gastrointestinal in vitro
Creators: name: MORETTI DE ALMEIDA, GABRIEL
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Currently, the idea of reducing dairy components as vehicles for probiotic agents has been promoted because of the high proportion of individuals who present lactose intolerance and allergy to milk protein components. Researchers suggest that lactose intolerance occurs in the sensitized intestinal mucosa, causing abdominal cramps, vomiting, intestinal constipation, fecal occult blood loss, and in more severe cases, intestinal obstruction and protein-losing enteropathy. Considering the pathologies related to food intolerance, new alternatives such as soy-based probiotic fermented beverages instead of dairy products have been emphasized in the diet, as they provide a beneficial modulation of the intestinal microbiota. The acidification kinetics was performed with the CINAC system of the different formulations at 42�C. The ternary co-culture composed of Lactococcus lactis (LL), Lactobacillus bulgaricus (LB), Streptococcus thermophilus (ST) was the highest acidification rate (Vmax 11.40 x 10-3 units pH / min) 10.12 hours to reach pH 4.5 (P <0.05), post acidification the Lactococcus lactis (LL) strain had the lowest significant acidification rate when compared to the others at 37�C p <0.05. And the ternary co-culture Lactobacillus plantarum Lactobacillus bulgaricus (LB) and Streptococcus thermophilus (ST) showed the highest acidification rate when compared to the other p <0.05, at 42�C, and the highest acidification rate was Lactococcus lactis (LL) with Lactobacillus plantarum (LP). In the microbiological count, all microorganisms at different temperatures and formulations maintained viability above 106 after 28 days of storage at 4�C. The thermodynamic parameters estimated for nisin irreversible thermal inactivation were energy, enthalpy and Gibbs free energy of activation of 155.1, 152.1-152.3 and 86.2-90.4 kJ/mol, respectively, and an activation entropy of 177.9-186.2 J mol-1 K-1.
Fine-mapping reveals novel alternative splicing of the dopamine transporter
Creators: name: Talkowski, Michael E.
name: Thomas, Pramod
name: Wood, Joel
name: Chen, Michael
name: Lopez, A. Javier
name: Watson, Annie
name: McCann, Kathleen L.
name: Owen, Michael
name: Lewis, David A.
name: Georgieva, Lyudmilla
name: Papasaikas, Panagiotis
name: Nimgaonkar, Vishwajit L.
name: O'Donovan, Michael
name: Kirov, George
name: Prasad, Konasale M.
name: Bamne, Mikhil
name: Yao, Jeffrey K.
name: Quinn, John
name: Ruderfer, Douglas
name: Leonard, Sherry
name: McClain, Lora
name: Sullivan, Patrick
name: Chowdari, Kodavali V.
name: Miyajima, Fabio
name: Mansour, Hader
name: Toncheva, Draga
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Center for Human Genetic Research, Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Harvard University, Boston, Massachusetts.Graduate Program in Biology and Biomedical Science, Yale University, New Haven, Connecticut.The dopamine transporter gene (, ) has been implicated in the pathogenesis of numerous psychiatric and neurodevelopmental disorders, including schizophrenia (SZ). We previously detected association between SZ and intronic variants that replicated in two independent Caucasian samples, but had no obvious function. In follow-up analyses, we sequenced the coding and intronic regions of to identify complete linkage disequilibrium patterns of common variations. We genotyped 78 polymorphisms, narrowing the potentially causal region to two correlated clusters of associated SNPs localized predominantly to introns 3 and 4. Our computational analysis of these intronic regions predicted a novel cassette exon within intron 3, designated E3b, which is conserved among primates. We confirmed alternative splicing of E3b in post-mortem human substantia nigra (SN). As E3b introduces multiple in-frame stop codons, the open reading frame is truncated and the spliced product may undergo nonsense mediated decay. Thus, factors that increase E3b splicing could reduce the amount of unspliced product available for translation. Observations consistent with this prediction were made using cellular assays and in post-mortem human SN. In mini-gene constructs, the extent of splicing is also influenced by at least two common haplotypes, so the alternative splicing was evaluated in relation to SZ risk. Meta-analyses across genome-wide association studies did not support the initial associations and further post-mortem studies did not suggest case-control differences in splicing. These studies do not provide a compelling link to schizophrenia. However, the impact of the alternative splicing on other neuropsychiatric disorders should be investigated. © 2010 Wiley-Liss, Inc.
title: Kontextualisierung qualitativer Forschungsdaten für die Nachnutzung: eine Handreichung für Forschende zur Erstellung eines Studienreports
title: Contextualizing qualitative research data for re-use: a guidance for researchers to prepare a study report
titleType: AlternativeTitle
Creators: name: Heuer, Jan-Ocko
name: Kretzer, Susanne
name: Mozygemba, Kati
name: Huber, Elisabeth
name: Hollstein, Betina
Publisher: name: Universität Bremen
Year: 2020
Subjects: subject: qualitative Forschungsdaten
subject: Forschungsdokumentation
subject: Kontextualisierung
subject: Data Sharing
subject: Archivierung
subject: Nachnutzung
subject: Sekundärnutzung
subject: Handreichung
subject: Studienreport
subject: 300

description: Die Kontextualisierung von qualitativen Forschungsdaten für weitere wissenschaftliche Nutzungen stellt eine der zentralen Herausforderungen im "Data Sharing" dar. Das Forschungsdatenzentrum Qualiservice möchte mit diesem Arbeitspapier Forschende bei der Kontextualisierung ihrer Forschungsmaterialien unterstützen. Die Handreichung enthält Empfehlungen für die Beschreibung und Dokumentation der Forschungsdaten. Im Mittelpunkt steht das Verfassen eines Studienreports, in dem das Forschungsprojekt, die Generierung der Daten und die Daten selbst beschrieben werden. Zur Einführung wird ein Überblick über die Bedeutung der Kontextualisierung und den Prozess der Kontextualisierung bei Qualiservice gegeben. Anschließend wird der Studienreport näher erläutert, mit dessen Hilfe sich Interessierte einen Überblick über die im Forschungsprojekt generierten Daten verschaffen können. Abschließend wird eine Vorlage für die Erstellung eines Studienreports präsentiert, die als Orientierung dienen soll und an die Erfordernisse des Forschungsprojekts angepasst werden kann.
Paper 1: The JWST PEARLS View of the El Gordo Galaxy Cluster and of the Structure It Magnifies
Creators: name: Frye, Brenda L.
name: Pascale, Massimo
name: Foo, Nicholas
name: Leimbach, Reagen
name: Garuda, Nikhil
name: Robles, Paulina Soto
name: Summers, Jake
name: Diaz, Carlos
name: Kamieneski, Patrick
name: Furtak, Lukas
name: Cohen, Seth
name: Diego, Jose
name: Beauchesne, Benjamin
name: Windhorst, Rogier
name: Willner, Steve
name: Koekemoer, Anton M.
name: Zitrin, Adi
name: Caminha, Gabriel
name: Caputi, Karina
name: Coe, Dan
name: Conselice, Christopher J.
name: Dai, Liang
name: Dole, Herve
name: Driver, Simon
name: Grogin, Norman
name: Harrington, Kevin
name: Jansen, Rolf A.
name: Kneib, Jean-Paul
name: Lehnert, Matt
name: Lowenthal, James
name: Marshall, Madeline A.
name: Menanteau, Felipe
name: Pampleiga, Belen Alcalde
name: Pirzkal, Nor
name: Polletta, Mari
name: Richard, Johan
name: Robotham, Aaron
name: Ryan, Russell E.
name: Rutkowski, Michael J.
name: Sifon, Christobal
name: Tompkins, Scott
name: Wang, Daniel
name: Yan, Haojing
name: Yun, Min S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The massive galaxy cluster El Gordo (z=0.87) imprints multitudes of gravitationally lensed arcs onto James Webb Space Telescope (JWST) Near-Infrared Camera (NIRCam) images. Eight bands of NIRCam imaging were obtained in the ``Prime Extragalactic Areas for Reionization and Lensing Science'' (``PEARLS'') program. PSF-matched photometry across Hubble Space Telescope (HST) and NIRCam filters supplies new photometric redshifts. A new light-traces-mass lens model based on 56 image multiplicities identifies the two mass peaks and yields a mass estimate within 500 kpc of ~(7.0 +/- 0.30) x 10^14 Msun. A search for substructure in the 140 cluster members with spectroscopic redshifts confirms the two main mass components. The southeastern mass peak that contains the BCG is more tightly bound than the northwestern one. The virial mass within 1.7 Mpc is (5.1 +/- 0.60) x 10^14 Msun, lower than the lensing mass. A significant transverse velocity component could mean the virial mass is underestimated. We contribute one new member to the previously known z=4.32 galaxy group. Intrinsic (delensed) positions of the five secure group members span a physical extent of ~60 kpc. Thirteen additional candidates selected by spectroscopic/photometric constraints are small and faint with a mean intrinsic luminosity ~2.2 mag fainter than L*. NIRCam imaging admits a fairly wide range of brightnesses and morphologies for the group members, suggesting a more diverse galaxy population in this galaxy overdensity.
description: 24 pages, accepted by ApJ
Measurements of the Higgs boson production and decay rates and coupling strengths using $pp$ collision data at $\sqrt{s}=7$ and $8$ TeV in the ATLAS experiment
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Combined analyses of the Higgs boson production and decay rates as well as its coupling strengths to vector bosons and fermions are presented. The combinations include the results of the analyses of the $H\toγγ,\, ZZ^*,\, WW^*,\, Zγ,\, b\bar{b},\, ττ$ and $μμ$ decay modes, and the constraints on the associated production with a pair of top quarks and on the off-shell coupling strengths of the Higgs boson. The results are based on the LHC proton-proton collision datasets, with integrated luminosities of up to 4.7 $\mathrm{fb}^{-1}$ at $\sqrt{s}=7$ TeV and 20.3 $\mathrm{fb}^{-1}$ at $\sqrt{s}=8$ TeV, recorded by the ATLAS detector in 2011 and 2012. Combining all production modes and decay channels, the measured signal yield, normalised to the Standard Model expectation, is $1.18^{+0.15}_{-0.14}$. The observed Higgs boson production and decay rates are interpreted in a leading-order coupling framework, exploring a wide range of benchmark coupling models both with and without assumptions on the Higgs boson width and on the Standard Model particle content in loop processes. The data are found to be compatible with the Standard Model expectations for a Higgs boson at a mass of 125.36 GeV for all models considered.
description: 69 pages plus author list + cover pages (85 pages total), 27 figures, 13 tables. Submitted to The European Physical Journal C. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2014-06/
Pluralism and Diversity: For the Sake of Equal Respect
Creators: name: BL�HOV�, SYLVIE
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: The dissertation addresses the issue of pluralism in liberal political theory and within a liberal political community. It challenges political liberalism?s focus solely on the essentially political level ? that is on the justification of the exercise of political power under the conditions of pluralism ?, as it overlooks other manifestations of pluralism equally important for a liberal political community. That concerns the so-called societal level as another formative level of a liberal political community characterized mainly by the differences among people due to their membership in diverse groups. One of the consequences of such a limited focus is that although political power is justified to citizens, still many them may feel being treated unfairly within a liberal political community. Since the author argues that the objective of the justification of political power is primarily to ensure equal respect, the possibility of having some people disrespected within a liberal political community is problematic for political liberalism. Accordingly, the objective of the dissertation is to find out the way to cover both spheres forming the public sphere of a liberal political community. By using the argumentation of political (public reason) liberalism, it aims to come to such an understanding of respect that would embrace both the essentially political and societal levels of a liberal political community. The author turns to the criterion of reciprocity ? as the basis of political legitimacy and the principle underlying the whole project of political liberalism ? and calls for its dual interpretation: the criterion of reciprocity is explained not only by means of the imperative of respect, but also by means of the idea of civic friendship. The role of the criterion of reciprocity interpreted by means of civic friendship is that it retrospectively influences the very character of respect. This is because civic friendship inherently shifts the understanding of the character of respect from the third-person imperative to the second-person act of recognition. This way, the argument from civic friendship allows to achieve respect both at the essentially political and societal levels of a liberal political community.
Informed consent in ethnographic research: A common practice facing new challenges
Creators: name: Huber, Elisabeth
name: Imeri, Sabine
Publisher: name: Universität Bremen
Year: 2021
Subjects: subject: research data management
subject: ethnographic research
subject: ethnographic fieldwork
subject: Informed consent
subject: research data archiving
subject: 300

description: In this article, we give some insight into the growing debate on informed consent among social and cultural anthropologists in Germany and beyond that takes as its current starting point the wider debate on the impacts of the General Data Protection Regulation (GDPR) as well as the requirements of research data management and archiving. This critical debate centres two aspects: the standardized written form and the time of consenting. We use examples from the broader field of qualitative social scientific research when they address similar problems. Subsequently we outline proceedings that could lead to non-written forms of consenting, which have proven more appropriate to ethnographic fieldwork.
No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition
Creators: name: Stroup, T. Scott
name: Keefe, Richard S.E.
name: Konneker, Thomas I.
name: Crowley, James J.
name: Van Den Oord, Edwin
name: Lieberman, Jeffrey A.
name: Perkins, Diana O.
name: Sullivan, Patrick F.
name: Quackenbush, Corey R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry-informative principal components as covariates, the effect of 5-HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868-1.172, P = 0.91). In cases only, 5-HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons.
Convergence of Estimated Option Price in a Regime switching Market
Creators: name: Goswami, Anindya
name: Nandan, Sanket
Publisher: name: arXiv
Year: 2015
Subjects: subject: Pricing of Securities (q-fin.PR)
subject: Probability (math.PR)
subject: Statistics Theory (math.ST)
subject: FOS: Economics and business
subject: FOS: Mathematics
subject: 60K15, 91B30, 91G20, 91G60

description: In an observed generalized semi-Markov regime, estimation of transition rate of regime switching leads towards calculation of locally risk minimizing option price. Despite the uniform convergence of estimated step function of transition rate, to meet the existence of classical solution of the modified price equation, the estimator is approximated in the class of smooth functions and furthermore, the convergence is established. Later, the existence of the solution of the modified price equation is verified and the point-wise convergence of such approximation of option price is proved to answer the tractability of its application in Finance. To demonstrate the consistency in result a numerical experiment has been reported.
description: 11 pages, 2 figures
THE IMPACT OF THE DEVELOPMENT OF MARKETING ACTIVITIES ON THE EFFICIENCY OF MANUFACTURING ENTERPRISES
Creators: name: Nishonova, Shakhnozakhon
Publisher: name: Zenodo
Year: 2023

description: This article analyzes the role of marketing in the development of the enterprise, the concept, essence and goals of marketing, the main elements of marketing activities, the concept and methods of profit management of the enterprise and the development of marketing activities in the enterprise.
Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes
Creators: name: Goldman, David
name: Thornton, Laura M.
name: Rotondo, Alessandro
name: Bloss, Cinnamon
name: Jonassaint, Charles R.
name: Szatkiewicz, Jin Peng
name: Kaye, Walter H.
name: Strober, Michael
name: Kaplan, Allan S.
name: Berrettini, Wade H.
name: Treasure, Janet
name: La Via, Maria
name: Bulik, Cynthia M.
name: Keel, Pamela K.
name: Woodside, D. Blake
name: Crawford, Steve
name: Crow, Scott
name: Mitchell, James E.
name: Fichter, Manfred M.
name: Johnson, Craig
name: Klump, Kelly L.
name: Bergen, Andrew W.
name: Magistretti, Pierre
name: Brandt, Harry
name: Halmi, Katherine A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.