399. Evaluation of Upper Extremity Function, Strength and Endurance in Patients with Takayasu Arteritis
Creators: name: Yeşim Ağyol1
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: <strong>Objectives</strong>: Takayasu Arteritis (TAK) is a large-vessel vasculitis that can cause ischemic symptoms due to stenosis and occlusion of the aorta and its main branches. Arterial ischemia is thought to negatively affect muscle strength, endurance and function. However, functional consequences of arterial ischemia due to subclavian involvement (which is seen in up to 80% of the cases) is unsufficiently assessed. The aim of this study is to quantitatively evaluate upper extremity strength, endurance and function in these patients. <strong>Methods</strong>: Patients (n=40, mean age: 45.8±13.4 years) who were classified according to ACR 1990 Criteria for TAK, followed in the Rheumatology Clinics of Marmara University Hospital and age and gender matched healthy volunteers (HC, n=40) were studied. Right and left hand grip strength measurement, arm ergometry and unsupported upper limb exercise (UULEX) tests were performed in all study participants and Quick-DASH questionnaire in TAK group. The relationship between the parameters evaluating the disease activity and the functional tests were analyzed with Spearman correlation analysis. <strong>Results:</strong> The symptom duration was 119.2±66.9 and the follow-up period 99.8±59.0 months in patients with TAK. Both left (TAK: 21 (12-42) kg vs HC: 25.5 (19-41) kg, p=0.001) and right hand grip measurements (TAK: 23 (12-46) kg vs. HC: 27 (18-45) kg, p=0.004) were significantly lower in TAK patients. Mean UULEX test measurements were 127 (48-490) seconds in TAK and 204 (80- 622) seconds in HC (p=0.001). Arm ergometry also resulted in significantly lower duration in patients with TAK (TAK: 355 (33-2100) seconds vs. HC: 1212 (305-2760) seconds, p=&lt;0.001). A positive correlation was found between UULEX and right and left hand grip measurements (respectively r=0.61, p=&lt;0.001; r = 0.47, p=0.002). UULEX test negatively correlated with right and left pain-VAS in TAK patients (r=-0,40, p=0,01; r=-0,43, p=0,006, respectively). The correlation of UULEX with age, BMI, acute phase reactants, ITAS-2010 and TADS were not significant. A negative correlation was present with the Quick-DASH score and right (r=-0.52, p=&lt;0.001) and left (r=-0.42, p=0.006) hand grips, and arm ergometry (r=-0.70, p=&lt;0.001). Quick-DASH score had a positive correlation with disease activity assessed by ITAS2010 (r=0.35, p=0.02). Degree of left subclavian artery involvement also correlated with Quick-DASH score (r=0.35, p=0.02). <strong>Conclusion:</strong> In Takayasu’s Arteritis, upper extremity strength, endurance and function are shown to be impaired compared to healthy controls. Pain was found to be the most important factor affecting all tests. Functional upper extremity tests and Quick-DASH questionnaire might be useful to assess the impact of arterial ischemia on upper extremity disease-related quality-of-life in patients with TAK, in both clinical trials and daily practice. <strong>Disclosures:</strong> None