cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: of Pirfenidone as salvage treatment for refractory bleomycin-induced lung injury: a case report of seminoma
Creators: name: Sakamoto, Koji
name: Ito, Satoru
name: Naozumi Hashimoto
name: Hasegawa, Yoshinori
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Summary of the treatment experience of BILI with novel therapeutic regimens. PubMed search was conducted in June 2017 with query terms “bleomycin lung toxicity” and “bleomycin lung injury” and limited to clinical studies and case reports, which identified 29 literatures for the recent 15 years. Within them, only 3 reports fulfilled the following criteria; 1) containing treatment information and 2) using pharmacological intervention other than medium-dose corticosteroids for treating BILI. These cases along with our current case were summarized in supplemental table. (PDF 122 kb)
Additional file 10: Table S18. of Characterization of the peripheral blood transcriptome and adaptive evolution of the MHC I and TLR gene families in the wolf (Canis lupus)
Creators: name: Guangshuai Liu
name: Honghai Zhang
name: Guolei Sun
name: Zhao, Chao
name: Shuai Shang
name: Xiaodong Gao
name: Xia, Tian
name: Xiufeng Yang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Wolf MHC I primer sets. (DOCX 19Â kb)
Report on the observed climate, projected climate, and projected  biodiversity changes for Banff National Park Of Canada under  differing levels of warming
Creators: name: Price, Jeff
name: Forstenhäusler, Nicole
name: Graham, Erin
name: Osborn, Timothy J.
name: Warren, Rachel
Publisher: name: Zenodo
Year: 2024

description: Banff National Park is among the top 25% of all non-marine protected areas, globally. As a park with varying topography, the higher elevations are relatively resilient to climate change, even with higher levels of warming. However, the lower elevations, along the main watercourses are more exposed to climate change and face more adaptation challenges.  Averaged over the entire area, with 4°C warming (global, above pre-industrial), the area is projected to remain climatically suitable for 66.9% of its terrestrial biodiversity (fungi, plants, invertebrates, and vertebrates), with 30.5% of its area remaining an overall refugia (remaining climatically suitable for >75% of the species) for biodiversity. However, if warming levels were held to 2°C, 73.4% of the area would remain a climatic refugia and the area would remain climatically suitable for 86.6% of its terrestrial biodiversity.

Between 1961-1990 and 1991-2020 the average monthly temperature has increased by -0.5° (October) - +1.9°C (January). With warming levels of 2.0°C the new average monthly temperature is equivalent to that only seen 1 in 3 years in 1961-1990 for April-October (up to 1 in 20 years for July). Half of the months have seen increases in precipitation (March-June) with the rest seeing declines. Models project that most months will become wetter except for July-September. These changes in precipitation, accompanied by warmer weather, suggest a potential increase in overall fire risk.  The number of consecutive months classified as in severe drought has nearly doubled between 1961-1990 and 1986-2015.  With 2°C warming (global, relative to pre-industrial) the number of months in severe drought is projected to double. 

Biodiversity adaptation options generally allow for business-as-usual conservation, especially at higher elevations, taking into account changes in extreme events (heat and severe drought). However, lower elevation areas would need increasing levels of adaptation effort, especially with warming levels of 2°C and above.
BindingDB Entry 50020449: Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Beta-glucuronidase and Heparanase, Taisho Pharmaceutical, Affinity

description: Small molecule binding data for protein Beta-glucuronidase and Heparanase, Uniprot P08236 and Q9Y251
Additional file 1: of Evaluation and comparison of computational tools for RNA-seq isoform quantification
Creators: name: Zhang, Chi
name: Baohong Zhang
name: Lih-Ling Lin
name: Shanrong Zhao
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Supplementary Method. Detailed command line parameters. Figure S1. Comparisons of the overall performance among different methods using TPM measure. Figure S2. Comparisons of the overall performance among different methods using counts measure. Figure S3. The impact of the number of exons on the accuracy of isoform quantification. Figure S4. Inaccuracy of isoform quantification for short transcripts in RSEM simulated dataset. Figure S5. The distribution of the ratios of TPM values between the most abundant isoforms and their corresponding genes in the HBRR-C4 sample. (PDF 663Â kb)
BindingDB Entry 50020448: Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, and Bromodomain-containing protein 4, Maruho Co., Affinity

description: Small molecule binding data for protein Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, and Bromodomain-containing protein 4, Uniprot O60885, P25440, Q15059, and Q58F21
BindingDB Entry 50020443: Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: NAD-dependent protein deacetylase sirtuin-1, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, and NAD-dependent protein deacylase sirtuin-5, mitochondrial, Xihua University, Affinity

description: Small molecule binding data for protein NAD-dependent protein deacetylase sirtuin-1, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, and NAD-dependent protein deacylase sirtuin-5, mitochondrial, Uniprot Q8IXJ6, Q96EB6, Q9NTG7, and Q9NXA8
Additional file 10: Table S18. of Characterization of the peripheral blood transcriptome and adaptive evolution of the MHC I and TLR gene families in the wolf (Canis lupus)
Creators: name: Guangshuai Liu
name: Honghai Zhang
name: Guolei Sun
name: Zhao, Chao
name: Shuai Shang
name: Xiaodong Gao
name: Xia, Tian
name: Xiufeng Yang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Wolf MHC I primer sets. (DOCX 19Â kb)
BindingDB Entry 50020442: Discovery and Characterization of Moracin C as an Anti-Gouty Arthritis/Hyperuricemia Candidate by Docking-Based Virtual Screening and Pharmacological Evaluation.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Solute carrier family 22 member 12 and Xanthine dehydrogenase/oxidase, Southern Medical University, Affinity

description: Small molecule binding data for protein Solute carrier family 22 member 12 and Xanthine dehydrogenase/oxidase, Uniprot P47989 and Q96S37
Proceraea bifidentata Ben-Eliahu 1977
Creators: name: Nygren, Arne
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Phyllodocida
Syllidae
Proceraea
Proceraea bifidentata

description: Proceraea bifidentata Ben­Eliahu, 1977 (Fig. 7A–D)
Procera bifidentata Ben­Eliahu, 1977: 87 –88, fig. 14A–C.
Material examined. Israel: holotype BMNH 1997.1076, Gulf of Elat, Dendropoma habitat, 30 Apr 1971.
Diagnosis. Proceraea with 9 large teeth alternating with 18 smaller in 2 rings, small teeth fused for half their length.
Description. Holotype mounted on slide, length 7.2 mm for 60–70 chaetigers, width 0.7 mm, but specimen compressed. Preserved material without colour markings. Ciliation not possible to assess.
Eyes confluent (Fig. 7A); eye spots present. Palps in dorsal view projecting 1/3 of prostomial length, fused. Nuchal epaulettes not possible to observe.
All antennae and tentacular cirri lost, first left dorsal cirri present, damaged. Dorsal cirri equal in length, 1/6–1/8 of body width. Absence/presence of cirrophores on tentacular cirri, and first dorsal cirri not possible to determine; cirrophores on dorsal cirri that are possible to inspect, absent (Fig. 7B). All appendages cylindrical.
Parapodial lobes rounded, small (Fig. 7B). Anterior chaetigers with 2 aciculae, 1 in median and posterior. Chaetal fascicle with 7–10 compounds. Chaetal blades with small distal tooth (Fig. 7C); serration present. Single thick bayonet chaetae (Fig. 7C), beginning at chaetiger 8.
Pharynx sinuated, lying outside body; position of trepan not known. Trepan with 27 teeth; 9 large and 18 smaller; 1 large alternating with 2 small, arranged in 2 rings (Fig. 7D); small teeth are fused for 1/2 their length. Basal ring present; infradental spines absent (Fig. 7D). Number of rows of muscle cells not possible to assess. Anal cirri lost.
Additional information. Ben­Eliahu described the nuchal epaulettes as covering the tentacular segment, and the proventricle as equal in length to 3 segments in chaetiger 6–8, with 50 rows of muscle cells.
Reproduction. Unknown.
Habitat. Dendropoma infauna.
Distribution. Indian Ocean, Gulf of Elat, only known from type specimen.
Remarks. Proceraea bifidentata is unique among Proceraea to have a trepan with 9 large and 18 smaller teeth. The trepan is very similar to the trepan found in Epigamia noroi Imajima & Hartman, 1964; P. bifidentata differs from E. noroi in e.g. the shape of bayonet chaetae.
description: Published as part of Nygren, Arne, 2004, Revision of Autolytinae (Syllidae: Polychaeta)., pp. 1-314 in Zootaxa 680 on pages 45-46, DOI: 10.5281/zenodo.157809
BindingDB Entry 50020441: HIV-1 Integrase Inhibitor, Dihydroobionin B, and the Investigation of Its Extraordinary Specific Rotation.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Integrase, Hirosaki University, Affinity

description: Small molecule binding data for protein Integrase, Uniprot Q7ZJM1
Proceraea boreata Imajima 1966, comb. n.
Creators: name: Nygren, Arne
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Phyllodocida
Syllidae
Proceraea
Proceraea boreata

description: Proceraea boreata (Imajima, 1966) comb. n. (Fig. 8A–D)
Autolytus (Regulatus) boreatus Imajima, 1966: 75 –77, fig. 24A–H.
Material examined. Japan: 1 paratype NSMT­Pol P­ 3, Cape Shiriyazaki, 140 m. Diagnosis. Proceraea with 2 longitudinal lines; trepan with 18 large and 9 smaller teeth, arranged in 2 rings.
Description. Length 14 mm for 64 chaetigers, complete, width 0.4 mm. Preserved material yellowish with 2 longitudinal brownish lines (Fig. 8A, B); eyes brownish red. Ciliation not possible to assess.
Eyes large, almost confluent (Fig. 8A); eye spots absent. Palps in dorsal view projecting c. 1/3 of prostomial length, fused. Extension of nuchal epaulettes to end of tentacular segment (Fig. 8A).
Antennae and anterior appendages lost or broken. Alternation in direction of cirri not assessed. Dorsal cirri from chaetiger 3, of equal length, 1/4 of body width. Cirrophores on tentacular segment and first dorsal cirri present; cirrophores otherwise absent. All appendages cylindrical, including lost anterior appendages (Imajima 1966).
Parapodial lobes rounded conical, small. Anterior chaetigers with 2 aciculae, 1 in median and posterior. Chaetal fascicle with 10–12 compounds in anterior chaetigers, 6–10 in median and posterior. Compound chaetae with small distal tooth (Fig. 8C); serration present. Single thick bayonet chaetae, beginning at chaetiger 30.
Pharynx with sinuation anterior to proventricle. Trepan with 27 unequal teeth; 18 large and 9 smaller; 2 large alternating with 1 small, arranged in 2 rings. Basal ring present; infradental spines absent. Proventricle equal in length to 2 segments in chaetiger 6–7 with c. 37 rows of muscle cells (Fig. 8D). Anal cirri equal in length to dorsal cirri.
Reproduction. Anterior scissiparity (Fig. 8B).
Habitat. Unknown.
Distribution. North East Pacific. Northern Japan.
Remarks. Proceraea boreata is very similar to P. okadai Imajima, 1966; in external features they are inseparable, and differ only in the number of teeth in the trepan.
description: Published as part of Nygren, Arne, 2004, Revision of Autolytinae (Syllidae: Polychaeta)., pp. 1-314 in Zootaxa 680 on pages 46-47, DOI: 10.5281/zenodo.157809
BindingDB Entry 50020440: Flindissone, a Limonoid Isolated from
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta, University of Vienna, Affinity

description: Small molecule binding data for protein Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta, Uniprot P55055 and Q13133
Eomedina
Creators: name: Cerretti, Pierfilippo
name: Wyatt, Nigel
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tachinidae
Eomedina

description: Key to females of Eomedina species
1. One pair of proclinate orbital setae. Two pairs of reclinate upper orbital setae. Abdominal tergites 3–5 each with one pair of strong median discal setae, outer median marginal setae on tergite 4 strong, as long as median pair. Four well defined black vittae on scutum and dark hind marginal bands on abdominal tergites conspicuous, the latter shiny black, broadened medially and more than half the width of tergites when viewed from above .......................................................................................... apicalis (Curran)
­ No proclinate orbital setae. One reclinate upper orbital seta. Median discal setae on tergites 3–5 weak, those on tergite 3 sometimes absent, outer median marginals on tergite 4 weak or absent. Four dark vittae on scutum grey and rather inconspicuous, hind marginal bands of abdominal tergites dark grey and not obviously shiny when viewed from above, occupying only up to a quarter of tergite length and not broadened medially ........................................................................................... hamoyensis sp. nov.
description: Published as part of Cerretti, Pierfilippo & Wyatt, Nigel, 2006, A new species of Eomedina Mesnil (Diptera: Tachinidae) from Namibia, pp. 61-68 in Zootaxa 1147 on page 67, DOI: 10.5281/zenodo.172102
BindingDB Entry 50020439: Discovery of novel hybrids of mTOR inhibitor and NO donor as potential anti-tumor therapeutics.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Serine/threonine-protein kinase mTOR, Anhui University of Chinese Medicine, Affinity

description: Small molecule binding data for protein Serine/threonine-protein kinase mTOR, Uniprot P42345
BindingDB Entry 50020438: Synthesis and evaluation of Fmoc-amino esters and amides bearing a substrate like quaternary ammonium group as selective butyrylcholinesterase inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cholinesterase, California State University, Affinity

description: Small molecule binding data for protein Cholinesterase, Uniprot P81908
BindingDB Entry 50020437: Isolation of Anti-SARS-CoV-2 Natural Products Extracted from
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Replicase polyprotein 1ab, National Taiwan University, Affinity

description: Small molecule binding data for protein Replicase polyprotein 1ab, Uniprot A0A679G4D8, A0A6B9V049, A0A6B9VP19, A0A6V7ALW7, and P0DTD1
Schiodtella Signoret 1882
Creators: name: Imura, Jimpei
name: Ishikawa, Tadashi
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cydnidae
Schiodtella

description: The genus Schiodtella Signoret, 1882
Schiodtella Signoret, 1882: 218, type species by subsequent designation (Lis 1994: 25): Stibaropus tabulatus Schiødte (syn. by Lis 1994: 24, with Stibaropus Dallas, 1851; restored by Lis 1999: 128).
Neostibaropus Takano and Yanagihara, 1939: 135, type species by monotypy: Neostibaropus formosanus Takano and Yanagihara (syn. by Esaki & Ishihara 1951: 30, with Stibaropus Dallas, 1851; by Lis 1991a: 169, with Schiodtella Signoret, 1882).
Lis (1991a) synonymized Neostibaropus with Schiodtella chiefly on the basis of having the four-segmented antennae, and afterwards, diagnosed the latter as “Head narrowed anteriorly, crenulated on margins; paraclypei with peg-like setae; clypeus parallel-sided or narrowed apically, shorter than paraclypei; antennae 4-segmented, second segment as long as or longer than the third; second rostral segment simple, without foliaceous lobe; apex of peritreme with small tooth-like process; margin of abdominal sternites straight in lateral parts; tarsi of all leg present” (Lis 1999). In addition to these characters, the 1+1 abdominal trichobothrial formula on the sternites III to VII is of taxonomic value for Schiodtella as documented by Lis and Hohol-Kilinkiewicz (2001). As Neostibaropus is clearly ascertained to have no tarsi, although it has almost all characters above, it is tempting to restitute Neostibaropus from the synonymy as a valid genus. However, we believe that maintainance of Neostibaropus as a synonym of Schiodtella, based on a careful survey on the comprehensive morphology among the species of Schiodtella and its allies (see below for the detailed discussion), should be kept. Herein we provide a modified diagnosis for Schiodtella, and add some characters that are important to define it.
Diagnosis. Head narrowed anteriorly, crenulated by fringe of peg-bearing tubercles on paraclypeal margin; clypeus parallel-sided or narrowed apically, shorter than paraclypei, with 2 subapical pegs. Antennae 4-segmented; segment II as long as or longer than segment III. Rostral segment II simple, without foliaceous lobe. Apical process of peritreme usually tooth-like, variable in length, but sometimes lacking. Tarsi present or absent. Posterior margin of abdominal sterna not insinuated; trichobothrial formula 1+1 on sternites III to VII (Fig. 21). Penis with conjunctival appendage of various lengths; spermathecal duct with large, globate, distinctly pigmented dilation.
description: Published as part of Imura, Jimpei & Ishikawa, Tadashi, 2009, A review of Schiodtella formosana, with some remarks on the genus Schiodtella and description of a Japanese new species (Hemiptera: Heteroptera: Cydnidae), pp. 19-30 in Zootaxa 2315 on pages 20-21, DOI: 10.5281/zenodo.192017
Leptotrombidium (Leptotrombidium) linjeromae Vercammen-Grandjean and Langston 1976
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium linjeromae

description: Leptotrombidium (Leptotrombidium) linjeromae Vercammen-Grandjean and Langston, 1976:
ORI
Leptotrombidium linjeromae, Stekolnikov 2013 [linjeromae group], 2021
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 133, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
BindingDB Entry 50020432: Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Heat shock protein HSP 90-alpha, Adam Mickiewicz University, Affinity

description: Small molecule binding data for protein Heat shock protein HSP 90-alpha, Uniprot P07900
BindingDB Entry 50020431: Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Isocitrate dehydrogenase [NADP] cytoplasmic and Isocitrate dehydrogenase [NADP], mitochondrial, Chinese Academy of Sciences, Affinity

description: Small molecule binding data for protein Isocitrate dehydrogenase [NADP] cytoplasmic and Isocitrate dehydrogenase [NADP], mitochondrial, Uniprot O75874 and P48735
BindingDB Entry 50020430: Optimization, and biological evaluation of 3-O-β-chacotriosyl betulinic acid amide derivatives as novel small-molecule Omicron.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Spike glycoprotein, South China Agricultural University, Affinity

description: Small molecule binding data for protein Spike glycoprotein, Uniprot P0DTC2
BindingDB Entry 50020425: Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta, Uniprot P05622 and P26618
Report on the observed climate, projected climate, and projected biodiversity changes for Big Bend National Park, Texas under differing levels of warming
Creators: name: Price, Jeff
name: Forstenhäusler, Nicole
name: Graham, Erin
name: Osborn, Timothy J.
name: Warren, Rachel
Publisher: name: Zenodo
Year: 2024

description: Big Bend National Park, Texas, is among the top 26% of all non-marine protected areas, globally. Big Bend is projected to be largely resilient to climate change to 2°C warming. As such, business as usual conservation, taking into account changes in the likelihood of extreme events (heat and drought), should largely be adequate. Beyond that, only the higher elevations are expected to remain resilient with the lower elevations requiring increasing adaptation effort. Individual species will be expected to shift upward in elevation, if they are able and those at the very top of the mountains may be extirpated. Averaged over the entire area, with 4°C warming (global, above pre-industrial), the area is projected to remain climatically suitable for 65.1% of its terrestrial biodiversity (fungi, plants, invertebrates, and vertebrates), with only 4% of its area remaining an overall refugia (remaining climatically suitable for >75% of the species) for biodiversity. If warming levels were held to 2°C, 54.4% of the area would remain a climatic refugia and the area would remain climatically suitable for 81.7% of its terrestrial biodiversity.

Between 1961-1990 and 1991-2020 the average monthly temperature has increased by 0.4° – 1.4°C (February). With warming levels of 2°C the new average monthly temperature is equivalent to that currently seen 1 in 3 years in 1961-1990 for all months except May and June (new average equal to that seen in 1 in 20 years). Eight months have seen decreases in precipitation (especially September), and the rest wetter, especially July. Models project that all months except July and August will become drier. The number of months with severe drought has more than quadrupled between 1961-1990 and 1986-2015.  With 2°C warming, more than half of the months in a 30-year period are projected to be in severe drought, with severe drought lengths of more than three years possible.

Biodiversity adaptation options generally only allow for business-as-usual conservation to 2.0°C, but this would only be possible if changes in extreme events (especially summer heat and severe drought) were taken into consideration.  Even with warming of 2°C and less, water may become increasingly scarce so water holes or guzzlers may be required to maintain existing biodiversity.  With warming above 2°C adaptation will become increasingly difficult as lengths of severe drought increase.  Only the highest elevations in the park would be able to potentially get by with business-as-usual conservation.
BindingDB Entry 50020423: Small-molecule LRRK2 inhibitors for PD therapy: Current achievements and future perspectives.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Dual specificity protein kinase CLK2 and Leucine-rich repeat serine/threonine-protein kinase 2, Sichuan University, Affinity

description: Small molecule binding data for protein Dual specificity protein kinase CLK2 and Leucine-rich repeat serine/threonine-protein kinase 2, Uniprot P49760, Q5S006, and Q5S007
BindingDB Entry 50020421: Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: 2-5A-dependent ribonuclease, Max Planck Institute of Molecular Physiology, Affinity

description: Small molecule binding data for protein 2-5A-dependent ribonuclease, Uniprot Q05823
BindingDB Entry 50020418: Inside PD-1/PD-L1,2 with their inhibitors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, Nantes University, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, Uniprot P05622, P26618, and Q9NZQ7
BindingDB Entry 50020417: Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Replicase polyprotein 1ab and mRNA cap guanine-N7 methyltransferase, University of Montpellier, Affinity

description: Small molecule binding data for protein Replicase polyprotein 1ab and mRNA cap guanine-N7 methyltransferase, Uniprot A0A679G4D8, A0A6B9V049, A0A6B9VP19, A0A6V7ALW7, O43148, P0C6X7, and P0DTD1
MOESM2 of Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Creators: name: Waller, Jessica
name: Nygaard, Sara
name: Li, Yan
name: Jardin, Kristian
name: Tamm, Joseph
name: Abdourahman, Aicha
name: Elfving, Betina
name: Pehrson, Alan
name: SĂĄnchez, Connie
name: Wernersson, Rasmus
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Figure S1. Merged mouse and rat network (mapped to human proteins) and summary of biological functions of each sub-network. Biological functions were manually extracted from the Function and Gene Ontology fields of the UniProt protein entries. The genes with dark, bold borders were used to build the network of proteinâ  protein interaction partners. Squares with bold borders represent upregulated targets from the rat network, and circles with bold borders indicate differentially-regulated targets from the mouse network. The arrowheads indicate the common targets found in mouse and rat networks. This network of physically-interacting proteins containing clusters related to synaptic plasticity, synaptic transmission, neurodevelopment, cell growth, metabolism, and apoptosis, was significantly modulated in both mouse and rat.
BindingDB Entry 50020415: Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Nuclear factor erythroid 2-related factor 2, Korea Institute of Science and Technology (KIST), Affinity

description: Small molecule binding data for protein Nuclear factor erythroid 2-related factor 2, Uniprot Q16236
MOESM2 of Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Creators: name: Waller, Jessica
name: Nygaard, Sara
name: Li, Yan
name: Jardin, Kristian
name: Tamm, Joseph
name: Abdourahman, Aicha
name: Elfving, Betina
name: Pehrson, Alan
name: SĂĄnchez, Connie
name: Wernersson, Rasmus
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Mental Health

description: Additional file 2: Figure S1. Merged mouse and rat network (mapped to human proteins) and summary of biological functions of each sub-network. Biological functions were manually extracted from the Function and Gene Ontology fields of the UniProt protein entries. The genes with dark, bold borders were used to build the network of proteinâ  protein interaction partners. Squares with bold borders represent upregulated targets from the rat network, and circles with bold borders indicate differentially-regulated targets from the mouse network. The arrowheads indicate the common targets found in mouse and rat networks. This network of physically-interacting proteins containing clusters related to synaptic plasticity, synaptic transmission, neurodevelopment, cell growth, metabolism, and apoptosis, was significantly modulated in both mouse and rat.
BindingDB Entry 50020414: NSD3: Advances in cancer therapeutic potential and inhibitors research.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase NSD2, Histone-lysine N-methyltransferase NSD3, and Histone-lysine N-methyltransferase, H3 lysine-36 specific, Peking University, Affinity

description: Small molecule binding data for protein Histone-lysine N-methyltransferase EHMT1, Histone-lysine N-methyltransferase EHMT2, Histone-lysine N-methyltransferase NSD2, Histone-lysine N-methyltransferase NSD3, and Histone-lysine N-methyltransferase, H3 lysine-36 specific, Uniprot O96028, Q96KQ7, Q96L73, Q9BZ95, and Q9H9B1
Leptotrombidium (Leptotrombidium) linji Wen and Sun 1984
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium linji

description: Leptotrombidium (Leptotrombidium) linji Wen and Sun, 1984 a:
PAL
Leptotrombidium linji, Stekolnikov 2013 [4 group]
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 133, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
BindingDB Entry 50020412: Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Polyunsaturated fatty acid lipoxygenase ALOX15, Prostaglandin G/H synthase 1, and Prostaglandin G/H synthase 2, Zagazig University, Affinity

description: Small molecule binding data for protein Polyunsaturated fatty acid lipoxygenase ALOX15, Prostaglandin G/H synthase 1, and Prostaglandin G/H synthase 2, Uniprot P05979, P16050, and P35354
Additional file 1: Figures S1-S8. of The first succinylome profile of Trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes
Creators: name: Xingye Xu
name: Liu, Tao
name: Yang, Jian
name: Lihong Chen
name: Liu, Bo
name: Candong Wei
name: Lingling Wang
name: Jin, Qi
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: All supplementary figures. (PDF 8848Â kb)
BindingDB Entry 50020410: A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAF
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Serine/threonine-protein kinase B-raf, University of Pisa, Affinity

description: Small molecule binding data for protein Serine/threonine-protein kinase B-raf, Uniprot P15056
BindingDB Entry 50020409: Current advances of small molecule E3 ligands for proteolysis-targeting chimeras design.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Bromodomain-containing protein 4, E3 ubiquitin-protein ligase RNF114, E3 ubiquitin-protein ligase RNF4, Elongin-C, Folliculin-interacting protein 1, Lethal(3)malignant brain tumor-like protein 3, and von Hippel-Lindau disease tumor suppressor, East China Normal University, Affinity

description: Small molecule binding data for protein Bromodomain-containing protein 4, E3 ubiquitin-protein ligase RNF114, E3 ubiquitin-protein ligase RNF4, Elongin-C, Folliculin-interacting protein 1, Lethal(3)malignant brain tumor-like protein 3, and von Hippel-Lindau disease tumor suppressor, Uniprot O60885, P40337, P78317, Q15369, Q96JM7, Q9UK73, and Q9Y508
BindingDB Entry 50020407: Targeting VPS34 in autophagy: An update on pharmacological small-molecule compounds.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, and Platelet-derived growth factor receptor alpha/beta, Southwest Jiaotong University, Affinity

description: Small molecule binding data for protein Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, and Platelet-derived growth factor receptor alpha/beta, Uniprot O00329, P05622, P26618, and Q8NEB9
Rapisma McLachlan 1866
Creators: name: Liu, Xingyue
name: Li, Di
name: Yang, Zizhong
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Ithonidae
Rapisma

description: Genus Rapisma McLachlan, 1866
Rapisma McLachlan, 1866: 353. Type species: Hemerobius viridipennis Walker, 1853: 276 (original designation).
Generic characters. See Liu (2018). Distribution. China, India, Indonesia, Malaysia, Myanmar, Nepal, Thailand.
description: Published as part of Liu, Xingyue, Li, Di & Yang, Zizhong, 2018, A new species of the montane lacewing genus Rapisma McLachlan (Neuroptera, Ithonidae) from China, pp. 266-270 in Zootaxa 4531 (2) on page 267, DOI: 10.11646/zootaxa.4531.2.7, http://zenodo.org/record/2614628
Additional file 1: Figures S1-S8. of The first succinylome profile of Trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes
Creators: name: Xingye Xu
name: Liu, Tao
name: Yang, Jian
name: Lihong Chen
name: Liu, Bo
name: Candong Wei
name: Lingling Wang
name: Jin, Qi
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: All supplementary figures. (PDF 8848Â kb)
BindingDB Entry 50020406: Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, and Serine/threonine-protein kinase SIK3, Sichuan University, Affinity

description: Small molecule binding data for protein Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, and Serine/threonine-protein kinase SIK3, Uniprot P57059, Q9H0K1, and Q9Y2K2
BindingDB Entry 50020405: Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3β inhibitory and neuroprotective activities against Alzheimer's disease.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Glycogen synthase kinase-3 beta, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein Glycogen synthase kinase-3 beta, Uniprot P49841
BindingDB Entry 50020404: Aporphines: A privileged scaffold in CNS drug discovery.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 7, Acetylcholinesterase, Cholinesterase, and Prolyl endopeptidase, Soochow University, Affinity

description: Small molecule binding data for protein 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 7, Acetylcholinesterase, Cholinesterase, and Prolyl endopeptidase, Uniprot O42275, P08908, P28223, P28335, P32305, P41595, P48147, and P81908
BindingDB Entry 50020402: Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Amine oxidase [flavin-containing] A and Heat shock protein HSP 90-alpha, University of Southern California, Affinity

description: Small molecule binding data for protein Amine oxidase [flavin-containing] A and Heat shock protein HSP 90-alpha, Uniprot P07900 and Q64133
MOESM2 of Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma
Creators: name: Cao, Chao
name: Li, Wen
name: Hua, Wen
name: Fugui Yan
name: Zhang, Hao
name: Huaqiong Huang
name: Yinghua Ying
name: Li, Na
name: Lan, Fen
name: Shaobin Wang
name: Chen, Xiao
name: Li, Jing
name: Jinkai Liu
name: Tianwen Lai
name: Zhengqiang Bao
name: Cao, Yuan
name: Zhao, Yun
name: Huang, Gang
name: Huang, Lili
name: Yaqing Huang
name: Wu, Ping
name: Peng, Chao
name: Zhihua Chen
name: Chung, Kian
name: Nanshan Zhong
name: Songmin Ying
name: Huahao Shen
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Figure S1. High expression of secreted protein in CA, CVA, or CTVA patients. AGT (A), ANXA1 (B), APOA1 (C), B2M (D), C5 (E), CHI3L1 (F), CTSB (G), FGA (H), FGB (I), FN1 (J), HPX (K), IL1RN (L), ITIH4 (M), ORM1 (N), PRG2 (O), and SERPINF (P). Mean values are represented as horizontal bars. *P < 0.05, **P < 0.01, ***P < 0.001; CA, classic asthma; CVA, cough-variant asthma; CTVA, chest tightness variant asthma.
BindingDB Entry 50020401: Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Nuclear receptor ROR-gamma, Fudan University, Affinity

description: Small molecule binding data for protein Nuclear receptor ROR-gamma, Uniprot P51449
Additional file 1: of Temperature-dependent Crystallization of MoS2 Nanoflakes on Graphene Nanosheets for Electrocatalysis
Creators: name: Xiaoru Guo
name: Hou, Yang
name: Ren, Ren
name: Junhong Chen
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Supporting Information for Temperature-dependent Crystallization of MoS2 Nanoflakes on Graphene Nanosheets for Electrocatalysis. (DOCX 1160 kb)
BindingDB Entry 50020400: Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cyclin-dependent kinase 2, Cyclin-dependent kinase 6, and Receptor-type tyrosine-protein kinase FLT3, Henan University of Chinese Medicine, Affinity

description: Small molecule binding data for protein Cyclin-dependent kinase 2, Cyclin-dependent kinase 6, and Receptor-type tyrosine-protein kinase FLT3, Uniprot P24941, P36888, and Q00534
MOESM2 of Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma
Creators: name: Cao, Chao
name: Li, Wen
name: Hua, Wen
name: Fugui Yan
name: Zhang, Hao
name: Huaqiong Huang
name: Yinghua Ying
name: Li, Na
name: Lan, Fen
name: Shaobin Wang
name: Chen, Xiao
name: Li, Jing
name: Jinkai Liu
name: Tianwen Lai
name: Zhengqiang Bao
name: Cao, Yuan
name: Zhao, Yun
name: Huang, Gang
name: Huang, Lili
name: Yaqing Huang
name: Wu, Ping
name: Peng, Chao
name: Zhihua Chen
name: Chung, Kian
name: Nanshan Zhong
name: Songmin Ying
name: Huahao Shen
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 2: Figure S1. High expression of secreted protein in CA, CVA, or CTVA patients. AGT (A), ANXA1 (B), APOA1 (C), B2M (D), C5 (E), CHI3L1 (F), CTSB (G), FGA (H), FGB (I), FN1 (J), HPX (K), IL1RN (L), ITIH4 (M), ORM1 (N), PRG2 (O), and SERPINF (P). Mean values are represented as horizontal bars. *P < 0.05, **P < 0.01, ***P < 0.001; CA, classic asthma; CVA, cough-variant asthma; CTVA, chest tightness variant asthma.
THE SCIENTIFIC SIGNIFICANCE OF TRAVEL REPORTS
Creators: name: Tabisxanov, Nursultan
Publisher: name: Zenodo
Year: 2024

description: Nursultan Tabisxanov's article discusses the scientific importance of travelogues, which document the observations and findings of explorers studying different regions. These reports combine adventure with scientific research, expanding knowledge in various fields. Travelogues provide valuable data on geography, flora, fauna, and culture, contributing to science and education. The article highlights the influence of explorers like Humboldt, Darwin, Wallace, and Merian, whose work in biology, geography, and ethnography shaped scientific thought. Despite modern technology, traditional methods of documenting observations remain essential for research.
MOESM1 of Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents
Creators: name: Waller, Jessica
name: Nygaard, Sara
name: Li, Yan
name: Jardin, Kristian
name: Tamm, Joseph
name: Abdourahman, Aicha
name: Elfving, Betina
name: Pehrson, Alan
name: SĂĄnchez, Connie
name: Wernersson, Rasmus
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. Differential expression analysis of mouse hippocampal qPCR data. A panel of 73 biomarkers was examined in a chronic vortioxetine study in aged mice and subject to differential analysis for identification of significantly-regulated targets to generate proteinâ  protein interaction networks. Table S2. Differential expression analysis of rat frontal cortex qPCR data. A panel of 80 biomarkers was evaluated in an acute vortioxetine study in adult rats and subject to differential analysis for identification of differentially-regulated targets to build proteinâ  protein interaction networks. Table S3. List of targets examined in OpenArray study. Gene expression levels of biomarkers related to transcriptional regulation, signal transduction, synaptic plasticity, neurotransmitter release, neurodevelopment, and degradation, and of receptors and channels were evaluated in a chronic vortioxetine study in adult rats. The targets outlined in red indicate additional genes identified in the network and pre-defined complex analyses.