title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Study of antimicrobial activity of pyrimidine derivatives
Creators: name: Ð§Ð¶Ð°Ð¾ Ð¤Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½
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ÑÑÐ½Ð³Ð¸ÑÐ¸Ð´Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
pyrimidine
pyrimidine derivatives
methyluracil
antimicrobial activity
fungicidal activity

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½Ð°, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ°ÑÑÐµÑÑ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¸Ð·ÑÑÐ°ÐµÐ¼ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð°ÐºÐµÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ PASS online, SwissADME, AntiFun Pred Ð¸ AntiBag Pred. Ð ÑÐ°Ð¼ÐºÐ°Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐµÑÐ°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: 1) ÐÑÐ±Ð¾Ñ Ð¾Ð±ÑÐµÐºÑÐ¾Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¿ÑÐ¸Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¿Ð¸ÑÐ°ÑÐµÐ»ÑÐ½ÑÑ ÑÑÐµÐ´ Ð´Ð»Ñ ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¼Ð¸ÐºÑÐ¾Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð¾Ð²; 2) ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½Ð°; 3) ÐÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ PASS online, SwissADME, AntiFun Pred Ð¸ AntiBag Pred. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ 6-Ð¼ÐµÑÐ¸Ð»ÑÑÐ°ÑÐ¸Ð» Ð±Ð¾Ð»ÐµÐµ Ð°ÐºÑÐ¸Ð²ÐµÐ½ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Escherichia coli. ÐÐ°Ð¸Ð±Ð¾Ð»ÑÑÑÑ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Bacillus subtilis, Saccharomyces boulardii, Rhodotorula rubra Ð¿ÑÐ¾ÑÐ²Ð¸Ð»Ð¾ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ðµ 2-Ð°Ð¼Ð¸Ð½Ð¾-4-Ð¼ÐµÑÐ¸Ð»-6-Ð¿ÐµÑÑÑÐ¾ÑÐ³ÐµÐºÑÐ¸Ð»Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½. Ð¡Ð¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ðµ 2-Ð¼ÐµÑÐ¸Ð»Ð¼ÐµÑÐºÐ°Ð¿ÑÐ¾-4-Ð¼ÐµÑÐ¸Ð»-6-Ð¿ÐµÑÑÑÐ¾ÑÐ³ÐµÐºÑÐ¸Ð»Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ¾ÐºÑÐ¸ÑÐ¸Ð½ÑÐ¼Ð¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÐºÐ»ÐµÑÐ¾Ðº Candida tropicalis. 2-Ð¼ÐµÑÐºÐ°Ð¿ÑÐ¾-4-Ð¼ÐµÑÐ¸Ð»-6-Ð¿ÐµÑÑÑÐ¾ÑÐ³ÐµÐºÑÐ¸Ð»- Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½ Ð¸ 2-Ð¼ÐµÑÐ¸Ð»Ð¼ÐµÑÐºÐ°Ð¿ÑÐ¾-4-Ð¼ÐµÑÐ¸Ð»-6-Ð¿ÐµÑÑÑÐ¾ÑÐ³ÐµÐºÑÐ¸Ð»Ð¿Ð¸ÑÐ¸Ð¼Ð¸Ð´Ð¸Ð½ Ð±Ð¾Ð»ÐµÐµ Ð°ÐºÑÐ¸Ð²Ð½Ñ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÐºÐ»ÐµÑÐ¾Ðº Aspergillus niger. ÐÑÐµ ÑÐµÑÑÑÐµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ Ð´ÐµÐ¹ÑÑÐ²ÑÑÑ Ð½Ð°Â  ÑÐ¾ÑÑ Ð¼Ð¸ÑÐµÐ»Ð¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð³ÑÐ¸Ð±Ð° Alternaria alternata. ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¹ ÐÐ¨ÐÐ¸ÐÐ. ÐÑÐ¸ Ð½Ð°Ð¿Ð¸ÑÐ°Ð½Ð¸Ð¸ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±Ð·Ð¾ÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð±Ð°Ð·Ñ Ð´Ð°Ð½Ð½ÑÑ: ÐÐºÐ°Ð´ÐµÐ¼Ð¸Ñ Google, eLIBRARY, PubMed. ÐÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ñ Adobe Photoshop Ð¸ Adobe Illustrator. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð°ÐºÐµÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Microsoft Excel. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð²ÐµÐ± ÑÐ°Ð¹ÑÐ¾Ð²: PASS online, SwissADME, AntiFun Pred Ð¸ AntiBag Pred.
description: This work is devoted to the study of antimicrobial properties of pyrimidine derivatives, as well as calculation of biological activity of the studied compounds using the package of programs PASS online, SwissADME, AntiFun Pred and AntiBag Pred. Within the framework of the graduate work the following tasks were solved: 1) Selection of research objects and preparation of nutrient media for cultivation of microorganisms. 2) Determination of antimicrobial properties of pyrimidine derivatives. 3) Prediction of biological activity using PASS online, SwissADME, AntiFun Pred and AntiBag Pred. The result of the study revealed that 6-methyluracil was more active against Escherichia coli. The compound 2-amino-4-methyl-6-perfluorohexylpyrimidine showed the highest antimicrobial activity against Bacillus subtilis, Saccharomyces boulardii, Rhodotorula rubra. The compound 2-methylmercapto-4-methyl-6-perfluorohexylpyrimidine is toxic to Candida tropicalis cells. 2-mercapto-4-methyl-6-perfluorohexyl-pyrimidine and 2-methylmercapto-4-methyl-6-perfluorohexylpyri-midine are more active against Aspergillus niger cells. All four compounds act on the growth of the mycelial fungus Alternaria alternata. This work was carried out on the basis of laboratories of VSBIPP. When writing the literature review, the following databases were used: Google Academy, eLIBRARY, PubMed. Qualitative processing of experimental data was performed using Adobe Photoshop and Adobe Illustrator program. Statistical processing of experimental data was carried out using Microsoft Excel program package. Prediction of properties and biological activity were studied using the following web sites: PASS online, SwissADME, AntiFun Pred and AntiBag Pred.