cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A novel apparatus/protocol designed for optogenetic manipulation and recording of individual neurons during a motivation and working memory task in the rodent
Creators: name: Cooper, Don
name: Dolzani, Samuel D.
name: Nakamura, Shinya
Publisher: name: figshare
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Neuroscience

description: Innovative molecular tools allow neuroscientists to study neural circuitry associated with specific behaviors. Consequently, behavioral methods must be developed to interface with these new molecular tools in order for neuroscientists to identify the causal elements underlying behavior and decision-making processes. Here we present an apparatus and protocol for a novel Go/No-Go behavioral paradigm to study the brain attention and motivation/reward circuitry in awake, head-restrained rodents. This experimental setup allows: (1) Painless and stable restraint of the head and body; (2) Rapid acquisition to simple or complex operant tasks; (3) Repeated electrophysiological single and multiple unit recordings during ongoing behavior; (4) Pharmacological and viral manipulation of various brain regions via targeted guide cannula, and; (5) Optogenetic cell-type specific activation and silencing with simultaneous electrophysiological recording. In addition to the experimental advantages, the head-restraint system is relatively inexpensive and training parameters can be easily modulated to the specifications of the experimenter. The system runs on custom LabView software. In summary, our novel apparatus and protocol allows researchers to study and manipulate components of behavior, such as motivation, impulsivity, and reward-related working memory during an ongoing operant behavioral task without interference from non task-related behaviors. For more information on the custom apparatus, software or to collaborate please visit www.neuro-cloud.net/nature-precedings/dolzani.
Control over stress induces plasticity of individual prefrontal cortical neurons: A conductance-based neural simulation
Creators: name: Cooper, Don
name: Varela, Juan
name: Varnell, Andrew
name: Jungang Wang
Publisher: name: figshare
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Behavioral control over stressful stimuli induces resilience to future conditions when control is lacking. The medial prefrontal cortex(mPFC) is a critically important brain region required for plasticity of stress resilience. We found that control over stress induces plasticity of the intrinsic voltage-gated conductances of pyramidal neurons in the PFC. To gain insight into the underlying biophysical mechanisms of this plasticity we used the conductance- based neural simulation software tool, NEURON, to model the increase in membrane excitability associated with resilience to stress. A ball and stick multicompartment conductance-based model was used to realistically fit passive and active data traces from prototypical pyramidal neurons in neurons in rats with control over tail shock stress and those lacking control. The results indicate that the plasticity of membrane excitability associated with control over stress can be attributed to an increase in Na+ and Ca2+ T-type conductances and an increase in the leak conductance. Using simulated dendritic synaptic inputs we observed an increase in excitatory postsynaptic summation and amplification resulting in elevated action potential output. This realistic simulation suggests that control over stress enhances the output of the PFC and offers specific testable hypotheses to guide future electrophysiological mechanistic studies in animal models of resilience and vulnerability to stress.
The statistical analysis of generalized adjacency and GA-clusters
Creators: name: Xu, Ximing
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Mathematics.
subject: Statistics.

description: In this thesis I study a parametrized definition of gene clusters that permits control over the trade-off between increasing gene content versus conserving gene order within a cluster. This is based on the notion of generalized adjacency, which is the property shared by any two genes no farther apart, in the linear order of a chromosome, than a fixed threshold parameter theta. We discuss the the statistical properties of generalized adjacency ( GA) and derive the limiting probability distribution of the number of GA for random genomes. We also propose a test for gene clusters satisfying the generalized adjacency criterion under the null hypothesis that the genes are ordered randomly along the genomes.
Supplementary material to "Robust 3D gravity gradient inversion by planting anomalous densities" by Leonardo Uieda and Valéria C. F. Barbosa
Creators: name: Uieda, Leonardo
name: Barbosa, Valeria C. F.
Publisher: name: figshare
Year: 2012
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences

description: We provide supplementary material to Uieda and Barbosa (2012). The material included are: (1) plots of the predicted and synthetic gyy and gyz components from the section "Application to synthetic data", (2) plots of the results of the sensitivity analysis to uncertainties in the density-contrast value of the seeds, (3) the contour maps of the synthetic and predicted data for the synthetic tests in the "Sensitivity analysis" section, and (4) a synthetic test ilustrating the use of the L2-norm of the residual vector in the data-misfit function. References Uieda, L., and V. C. F. Barbosa (2012), Robust 3D gravity gradient inversion by planting anomalous densities, Geophysics, 77(4), G55-G66, doi:10.1190/geo2011-0388.1.
A call for disruptive innovation in science publishing with a new open data-sharing platform for the life sciences
Creators: name: Cooper, Don
Publisher: name: figshare
Year: 2012
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Botany
subject: Cancer
subject: Parasitology
subject: Marine Biology
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Toxicology
subject: Biological Engineering
subject: Paleontology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Behavioral Neuroscience
subject: Anatomy
subject: Microbiology
subject: Medicine
subject: Biophysics

description: “A disruptive innovation is an innovation that helps create a new market and value network, and eventually goes on to disrupt an existing market and value network (over a few years or decades), displacing an earlier technology. The term is used in business and technology literature to describe innovations that improve a product or service in ways that the market does not expect.” -Wikipedia
On April 3rd, 2012 Nature Precedings, Nature Publishing Group’s experiment in free pre-print publishing was shut down and no longer accepts submissions. According to the Nature Precedings website it was created in 2007 as “a place for researchers to share documents, including presentations, posters, white papers, technical papers, supplementary findings, and non-peer-reviewed manuscripts.” It was designed to “provide a rapid means for scientists to share preliminary findings, disseminate emerging results, solicit community feedback, and claim priority over discoveries.” It was designed in a way to “make such material easy to archive, share and cite.” Now that Nature Precedings is no more, a new disruptive open data-sharing platform (ODSP) for the life sciences is needed. Based, in part, by the model Nature Precedings established. Here I propose 5 qualities of an ideal ODSP and outline 10 benefits (see Table 1) to scientists for embracing such a potentially disruptive model.
La résilience de l'autoritarisme en Chine: Une déconstruction critique de l'argumentaire culturaliste
Creators: name: Payette, Alex
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Asian Studies.
subject: Political Science, General.

description: La thèse propose une déconstruction critique de l'argumentaire culturaliste, en la comparant à l'argumentaire constructiviste, au sein du débat sur les facteurs explicatifs de la résilience de l'autoritarisme en Chine contemporaine. La critique se pose comme réfutation herméneutique, épistémologique, historique ainsi que politique de l'argumentaire culturaliste. La thèse s'attaque principalement à l'analogie faite entre les concepts de confucianisme, de culture chinoise ainsi que d'autoritarisme. Elle soulève des questions sur le sens ainsi que la construction de ces concepts. Elle tente, en ce sens, de remettre en cause l'interprétation ainsi que les liens existants entre ces derniers pour faire l'état du débat ainsi que pour pousser la réflexion sur la résilience autoritaire de la Chine vers d'autres explications possibles. Le projet en lui-même, parce que limité, ne pose pas directement la question de la résilience autoritaire, il tente néanmoins modestement de réduire la portée de l'explication culturaliste concernant ce phénomène en Chine.
Recommendations on the use of restrictions and assistive devices after total hip arthroplasty: an adolopment of guidelines
Creators: name: Ruspi, Alessandra
name: De Leo, Davide
name: Scandelli, Francesco
name: Tosetto, Valeria
name: Dosella, Silvia
name: Di Mento, Lorenzo
name: De Donato, Massimo
name: Sconza, Cristiano
name: Rosa, Francesco
name: Di Matteo, Berardo
name: Della Rocca, Federico
name: Azzolini, Elena
name: Grappiolo, Guido
name: Schünemann, Holger
name: Gatti, Roberto
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Biotechnology
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Science Policy

description: Movement restrictions and assistive devices have traditionally been recommended to prevent hip dislocation after total hip arthroplasty (THA). Considering the advancements in THA surgery, a review of treatment recommendations is worthwhile. The aim of this study was to investigate whether unrestricted protocol (without movement restrictions and assistive devices) should be recommended for THA patients. A multiprofessional panel used the GRADE-Adolopment to develop the present recommendations, following the GIN-McMaster-Guideline-Development-Tool. We selected guideline topic and target audience, formulated clinical questions and prioritised outcomes. For the first question, a source guideline was identified and adoloped, whereas the second question required a de-novo recommendation. Therefore, the GRADE-Evidence-Profile and the Evidence-to-Decision framework were completed. Finally, the panel discussed and formulated the final recommendations. Hip dislocation was defined as critical outcome. No between-groups differences in the early dislocation rates were found: without movement restrictions, 1623 patients, RR 0.44 (CI95 0.16–1.20); without assistive devices, 4426 patients, RR 0.75 (CI95 0.52–1.08). Finally, considering small desirable health effects and trivial undesirable health effects of the intervention, we integrated two “conditional-recommendations” in favour of an unrestricted protocol. Through GRADE-adolopment approach new recommendations to provide an evidence-based guidance after THA have been formulated. For patients undergoing total hip arthroplasty (THA), unless otherwise indicated by the surgeon, the removal of movement restrictions and assistive devices early after THA does not affect hip dislocation rate, regardless of surgical approach. On the other hand, unrestricted protocols may enhance a more rapid recovery process, shorter length of stay and less caregiver assistance. A more liberal lifestyle early after THA surgery (e.g., no mandatory sleeping posture) is associated with higher patient’s satisfaction. The non-routine adoption of movement restriction and assistive devices allows a costs reduction for both patients and the healthcare system after THA.
Excavations and surveys in Norfolk, 2002
Creators: name: Gurney, David
name: Penn, Kenneth
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (2), 368-385
description: Annual report comprising summaries of archaeological investigations, fieldwork and surveys carried out during 2002 in Norfolk; arranged alphabetically by parish, town or (in one case) road number, with sections on investigations giving negative results, 2001 corrigenda and 2001 addenda.
Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex
Creators: name: Cooper, Don
name: Cooper, Donald C.
name: Baratta, Michael
name: Dolzani, Samuel D.
name: Dobelis, Peter
name: Nakamura, Shinya
Publisher: name: figshare
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Behavioral Neuroscience

description: A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information among prefrontal neuronal subtypes is the inability to manipulate the electrical activity of genetically defined cell types over behaviorally relevant timescales and activity patterns. To address these constraints, we present here a simple approach for selective activation of prefrontal excitatory neurons in both in vitro and in vivo preparations. Rat prelimbic pyramidal neurons were genetically targeted to express a light-­activated nonselective cation channel, channelrhodopsin-­2, or a light-­driven inward chloride pump, halorhodopsin, which enabled them to be rapidly and reversibly activated or inhibited by pulses of light. These light responsive tools provide a spatially and temporally precise means of studying how different cell types contribute to information processing in cortical circuits. Our customized optrodes and optical commutators for in vivo recording allow for efficient light delivery and recording and can be requested at www.neuro-­cloud.net/nature-precedings/baratta.
Francis Blomefield as a historian of Norwich
Creators: name: Stoker, David
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 387-405
description: Second of two papers seeking to examine the credentials of Francis Blomefield as historian of the county of Norfolk. The article looks at Blomefield's history of Norwich, and considers the issue of whether Blomefield was a historian, an antiquary or a topographer.
Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation
Creators: name: Cooper, Don
name: Baratta, Michael
name: Pomrenze, Matt
Publisher: name: figshare
Year: 2012
Subjects: Pharmacology
Neuroscience
Behavioral Neuroscience

description: The number of emergency department visits concerning sport related TBI in youth increased 57% from 2001 to 2009 and while a fraction of that increase may be attributed to injuries that were once missed now being identified due to greater general awareness, the fact remains that there are nearly 200,000 children every year who suffer sport related concussion or other TBI serious enough to prompt a visit to the ED. 40% of sports related concussions involve children between the ages of 8 and 13, and in this group the rate of concussion doubled between 1997 and 2007. The risk of concussion is highest in football and there are nearly 67,000 diagnosed concussions in high school football every year. In other sports that males and females play, such as basketball, girls seem to be at a higher risk. In high schools, concussions account for 15% of all sports related injuries resulting in at least one day of play lost. The risk of a suffering a concussion when participating in a contact sport may be as high as 20% per season. In both girls’ and boys’ soccer and basketball 20% of the concussions were repeat concussions. These statistics just further illustrate the gravity of the problem of sport related concussions. Here we describe the need for more work on education, legislation and research in order to change in the concussion/mTBI culture.
The alien priory of St Winwaloe and Winnold House at Wereham, Norfolk
Creators: name: Impey, Edward A
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 432-455
description: Property at Wereham was given to the abbey of St Gu�nol� (Winwaloe) at Montreuil-sur-Mer between 1086 and 1154. Monks were probably installed before 1154, and were certainly present by the time the chapel was built c. 1150--75. The chapel's remains show that a claustral plan was not intended, while the monks' income limited their numbers to two or three. The monks' main duty was the collection of the abbey's revenues and the full conventual routine was not attempted; however the structure and decoration of the chapel indicate the importance that monasteries and patrons attached to such foundations in the twelfth century. The abbey sold the property in 1327, and in 1332 it passed to the Premonstratensians at West Dereham. Thereafter, at least until the 1370s, the chapel served as a chantry, and had a gallery or upper chamber inserted at its west end. The building was converted to domestic use after 1539.
What is the Common Drug Review?
Creators: name: Therapeutics Initiative (University Of British Columbia)
Publisher: name: The University of British Columbia
Year: 2023

description: Therapeutics Letter 61 outlines the Common Drug Review (CDR) process in Canada and uses examples from four drug reviews. The Common Drug Review is a standardized process whereby the relative therapeutic and cost effectiveness of new brand name drugs is reviewed for government drug plans across Canada. The full drug reviews are used by CEDAC to develop listing recommendations and rationales for the recommendations, available on the CDR website: www.cadth.ca/index.php/en/cdr. At the present time full drug reviews are not open to the public.
`Smithdon Hill', Snettisham: the possible meeting-place of Smethdon Hundred
Creators: name: Whyte, Nicola
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 522-525
description: Discussion of the place-name `Smithdon Hill', recorded on a map of c. 1625, and of the possibility of it being the hundred meeting place for Smethdon Hundred in north Norfolk.
PERTEMUAN 7_05 NOVEMBER 2024 AKUNTANSI UNTUK PENJUALAN ANGSURAN AKTIVA TETAP_UNIVERSITAS GRESIK
Creators: name: Dr. Rusdiyanto, SE,. M. Ak,. CH,. CHt, .
name: Prof. Dr. Nur Fadjrih Asyik, SE,. M. Si,. Ak,. CA,. CFA, .
Publisher: name: Zenodo
Year: 2024

description: Capaian Pembelajaran Mata Kuliah (CPMK)

Mahasiswa Mampu mengerjakan perhitungan Akuntansi Untuk Penjualan Angsuran Aktiva Tetap
Steger, Brigitte: (Keine) Zeit zum Schlafen? Kulturhistorische und sozialanthropologische Erkundungen japanischer Schlafgewohnheiten
Creators: name: Wu, Xiujie
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 93 (2004): ASIEN (Oktober)
Depressed Mothers and Problem Behaviours in their Adolescent Daughters: The mediating roles of parenting and attachment security
Creators: name: Kerr, Matthew A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Psychology, Behavioral.
subject: Psychology, Developmental.
subject: Psychology, Clinical.

description: Symptoms and episodes of depression in mothers consistently predict internalizing and externalizing symptoms in their children. Depression is also associated with attachment anxiety and avoidance, and poor parenting practices, which in turn also predict problem outcomes in youth. As girls enter puberty, rates of depression begin to increase dramatically relative to boys, which makes this developmental period well-suited to studying the mechanisms through which maternal depression may lead to depression and other unwanted symptoms in their adolescent daughters. One hundred and fifty-one mother-daughter pairs from two Canadian cities were interviewed with respect to their current and past mental health status. Mothers completed questionnaires with respect to their own depressive symptoms, romantic attachment, parenting practices, and their daughters' disruptive behaviours. Girls completed measures of their own symptoms of depression, their attachment to their mother, and aspects of their mothers' parenting. Daughter outcomes of depression and disruptive behavior were assessed again one year later. Mothers' parenting practices fully mediated the pathway between maternal depression and daughters' disruptive behavior. In combination with daughters' attachment to their mothers, parenting partially mediated the same relationship one year later. Parenting and attachment also significantly predicted daughters' depressive symptoms at Time I. After controlling for the influence of mothers' parenting, daughters' attachment, and daughters' outcomes at Time I, maternal depression at Time I continued to significantly and directly predict both daughter outcomes one year later. Combined, these results suggest that maternal depression may in part impact on daughters disruptive behavior through its influence on mothers' parenting, which in turn helps to shape daughters' attachment to their mothers. The fact that mothers' depressive symptoms also uniquely predict Time 2 outcomes indicates that there may be complex elements of the depression construct, not assessed in the present study, that influence adolescent well-being in a more insidious manner.
Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation
Creators: name: Cooper, Don
name: Baratta, Michael
name: Pomrenze, Matthew
name: Cadle, Brian
Publisher: name: figshare
Year: 2012
Subjects: Pharmacology
Neuroscience
Biotechnology
Behavioral Neuroscience

description: Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost mouse self-administration catheter assembly and protocol that that can be used to assess a variety of drugs of abuse with a variety of protocols. We describe a method for intravenous catheter fabrication that allows for efficient and long-lasting intravenous drug delivery. The intravenous catheters remained intact and patent for several weeks allowing us to establish stable maintenance of cocaine acquisition. This was followed by a dose response study in the same mice. For collaborators interested in premade catheters for research please make a request at www.neuro-cloud.net/nature-precedings/pomerenze.
Changing the Culture of â€œDingâ€ : Education, Legislation and Research on Concussive Brain Injury in Youth Athletics
Creators: name: Cooper, Don
name: Overturf, Claire D.
name: Cooper, Donald C.
Publisher: name: figshare
Year: 2012
Subjects: subject: Science Policy
subject: Neuroscience
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Behavioral Neuroscience

description: The number of emergency department visits concerning sport related TBI in youth increased 57% from 2001 to 2009 and while a fraction of that increase may be attributed to injuries that were once missed now being identified due to greater general awareness, the fact remains that there are nearly 200,000 children every year who suffer sport related concussion or other TBI serious enough to prompt a visit to the ED. 40% of sports related concussions involve children between the ages of 8 and 13, and in this group the rate of concussion doubled between 1997 and 2007. The risk of concussion is highest in football and there are nearly 67,000 diagnosed concussions in high school football every year. In other sports that males and females play, such as basketball, girls seem to be at a higher risk. In high schools, concussions account for 15% of all sports related injuries resulting in at least one day of play lost. The risk of a suffering a concussion when participating in a contact sport may be as high as 20% per season. In both girls’ and boys’ soccer and basketball 20% of the concussions were repeat concussions. These statistics just further illustrate the gravity of the problem of sport related concussions. Here we describe the need for more work on education, legislation and research in order to change in the concussion/mTBI culture.
Factors associated with premature mortality among young injection drug users in Vancouver
Creators: name: Miller, Cari L.
name: Kerr, Thomas
name: Strathdee, Steffanie A
name: Li, Kathy
name: Wood, Evan
Publisher: name: BioMed Central
Year: 2015

description: Background: Young injection drug users (IDUs) may be at increased risk of premature mortality due to the health risks associated with injection drug use including overdoses and infections. However, there has been little research conducted on mortality causes, rates and associations among this population. We undertook this study to investigate patterns of premature mortality, prior to age 30 years, among young IDUs. Methods Since 1996, 572 young (≤29 years) IDUs have been enrolled in the Vancouver Injection Drug Users Study (VIDUS). Semi-annually, participants have completed an interviewer-administered questionnaire and have undergone serologic testing for HIV and hepatitis C (HCV). Mortality data have been continually updated through linkages with the Provincial Coroner's Office. Crude and age-specific mortality rates, standardized mortality ratios, and life expectancy measures were calculated using person-time methods. Predictors of mortality were identified using Cox regression analyses. Findings Twenty-two participants died prior to age 30 years during the follow-up period for an overall crude mortality rate of 1,368 per 100,000 person-years. Overall, young IDUs were 16.4 times (95% confidence interval [CI]; 9.1–27.1) more likely to die; young women IDUs were 54.1 times (95%CI; 29.6–90.8) and young men IDUs were 12.9 times (95%CI; 5.5, 25.3) more likely to die when compared to the Canadian non-IDU population of the same age. The leading observed cause of death among females was: homicide (N = 9); and among males: suicide (N = 3) and overdose (N = 3). In Cox regression analyses, factors associated with mortality were, HIV infection (Hazard Ratio [HR]: 4.55; CI: 1.92–10.80) and sex work (HR: 2.76; CI: 1.16–6.56). Interpretation Premature mortality was 13 and 54 times higher among young men and women who use injection drugs in Vancouver than among the general population in Canada. The majority of deaths among the women were attributable to homicide, suggesting that interventions should occur not only through harm reduction services but also through structural interventions at the legal and policy level.
Rates of inappropriate antiretroviral prescription among injection drug users
Creators: name: Wood, Evan
name: Hogg, Robert S.
name: Kerr, Thomas
name: Bonner, Simon
name: Strathdee, Steffanie A.
name: Palepu, Anita
name: Montaner, Julio
Publisher: name: BioMed Central
Year: 2015

description: Background: Although the survival benefits of antiretroviral therapy (ART) for the treatment of HIV infection are well established, the clinical management of HIV disease continues to present major challenges. There are particular concerns regarding access to appropriate HIV treatment among HIV-infected injection drug users (IDU). Methods In a prospective cohort study of HIV-infected IDU in Vancouver, Canada, we examined initial ART regimens vis-à-vis the provincial government's therapeutic guidelines at the time ART was initiated. Briefly, there have been four sets of guidelines: Era 1 (1992 to November 1995; double-drug (dual NRTIs) ART for patients with a CD4 cell count of 350 or less); Era 2 (December 1995 to May 1996; double-drug therapy for patients with a CD4+ cell count of 500 or less); Era 3 (June 1996 to June 1997; triple-drug therapy (dual NRTIs with a PI or NNRTI) for patients who had a plasma viral load of > 100,000 HIV-1 RNA copies/mL; dual therapy with two NRTIs for those with a plasma viral load of 5,000 to 100,000 HIV-1 RNA copies/mL); Era 4 (since July 1997; universal use of triple drug therapy as first-line treatment). Results Between May 1996 and May 2003, 431 HIV-infected individuals were enrolled into the cohort. By May 31, 2003, 291 (67.5%) individuals had initiated ART. We noted instances of inappropriate antiretroviral prescription in each guideline era, with 9 (53%) in Era 1, 3 (12%) in Era 2, 22 (28%) in Era 3, and 23 (15%) in Era 4. Of the 57 subjects who received an inappropriate ART regimen initially, 14 never received the appropriate therapy; among the remaining 43, the median time to the initiation of a guideline-appropriate ART regimen was 12 months (inter-quartile range 5 – 20). Conclusion The present study identified measurable rates of guideline-inappropriate ART prescription for patients who were injection drug users. Rates were highest in the era of dual therapy, although high rates persisted into the triple-therapy era. As therapeutic guidelines continue to evolve, it is critical that mechanisms be put in place to ensure prescription of ART combinations for IDU that are consistent with current expert recommendations.
A Romano-British pottery kiln at Blackborough End, Middleton
Creators: name: Gurney, David
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 41 (1), 83-92
description: A roughly oval semi-sunken fired clay pottery kiln, with two integral D-shaped pilasters, was excavated. The pottery recovered from the fill of the kiln and surrounding area suggests that it was producing a range of vessels in Nar Valley ware, probably during the third century AD.
Evolution of DNA repair genes, proteins and processes
Creators: name: Eisen, Jonathan
Publisher: name: figshare
Year: 2012
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: PhD Thesis of Jonathan A. Eisen.
Exploration des pratiques de littératie familiales chez des élèves hispanophones scolarisés en première année en Outaouais
Creators: name: Bastien, Marie-Pier
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Socialisation à l'écrit
Langue seconde
Littératie familiale
Langue de scolarisation

description: Cette thèse porte sur une problématique en éducation, soit l’exploration des pratiques de littératie familiales chez des élèves hispanophones scolarisés en première année en Outaouais. Pour ce faire, des concepts tels que la langue de scolarisation, la littératie, la littératie familiale et la socialisation à l'écrit sont abordés. Notre intérêt et la justification du choix de notre sujet résident, d'une part, et selon notre connaissance, en la paucité des recherches qui portent sur l'apprentissage du français de scolarisation chez des élèves hispanophones de première année. D'autre part, il semblerait qu'au Québec, et notamment en Outaouais, les hispanophones sont plus fragiles quant à la réussite scolaire, car leurs connaissances et leur compréhension de langue de scolarisation, à savoir le français, ne sont pas suffisamment solides (Mc Andrew, 2009). Ainsi cherchons-nous à documenter les pratiques de littératie familiales d'élèves hispanophones pour mieux saisir leur socialisation, et, par le fait même, comprendre les difficultés potentielles qu'ils rencontrent relativement au français de scolarisation. Plus précisément, cette thèse vise à décrire les connaissances initiales des élèves au regard du principe alphabétique (ex. linéarité, orientation, etc.) et du code alphabétique (ex. connaissance des lettres, des syllabes et des phonèmes) relatifs au français langue de scolarisation et à explorer les pratiques de littératie familiales. Selon nous, une meilleure connaissance du rapport à l'écrit d'élèves hispanophones de première année, niveau charnière dans l’apprentissage du lire-écrire, nous permettrait de proposer des pistes didactiques et pédagogiques afin d'améliorer leur appréhension de la langue de scolarisation.
Supplementary Online Material
Creators: name: Rath, David
name: Mikerásek, Vojtěch
name: Wang, Chunlei
name: Eder, Moritz
name: Schmid, Michael
name: Diebold, Ulrike
name: Parkinson, Gareth
name: Pavelec, Jiří
Publisher: name: AIP Publishing
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 40
subject: Engineering
classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Supporting Information: Infrared Reflection Absorption
Spectroscopy Setup with Incidence Angle Selection for
Surfaces of Non-Metals
WHY STUDENTS ARE CHOOSING CRIMINAL JUSTICE MAJORS
Creators: name: Flores, Jazmin
Publisher: name: Zenodo
Year: 2022
Subjects: qualitative
research
criminal justice
higher education
careers

description: My senior honors project is based on the question “Why do people choose to go into the criminal justice field?” that was raised during the introductory conversation with a professor. We were discussing how the field itself is very diverse in reasons for entering, that we ourselves had different reasons for first choosing the major/career. I will be using a survey sent out in a mass email to all criminal justice-associated students to participate. With a total of 207 participants, they answered a series of questions about why they chose the major/minor, whether or not they have had a past loved one within the criminal justice system, what they plan to do, and a few demographic questions. These answers will help fulfill that question and help further the research on why students are choosing criminal justice majors.
title: How to Think Black: A Symposium in Toni Cade Bambara's The Salt Eaters
title: How to Think Black
titleType: AlternativeTitle
Creators: name: Frye, Charles A.
name: Harper, Charlyn
name: Myers, Linda James
name: Traylor, Eleanor W.
Publisher: name: University of Massachusetts Amherst
Year: 2024
Subjects: subject: black cognitive process
subject: The Salt Eaters

description: The Salt Eaters, which is the alleged topic ofthis symposium, is an extremely important work for any number of reasons, not the least of which is that it is the embodiment ofhow one thinks and writes "black." To help us understand both the black cognitive process and its literary embodiment, I have convened this very distinguished, interdisciplinary panel of scholars.
Schefold, Reimar; Domenig, Gaudenz; Nas, Peter (Eds.): Indonesian Houses - Tradition and transformation in vernacular architecture
Creators: name: Scholz, Ulrich
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 93 (2004): ASIEN (Oktober)
Evidence Based Practice - Step 2 - Appraising the Evidence: Practical Session
Creators: name: Hoens, Alison
name: Leznoff, Sandy
Publisher: name: The University of British Columbia
Year: 2007

description: EBP STEP 2 - APPRAISING THE EVIDENCE - How do I know the article is any good? Step 2: How to appraise the literature (Quantitative articles – practical session). This is a workshop presented by BC RSRnet (BC Rehabilitation Sciences Research Network) for British Columbia physiotherapists and occupational therapists on January 11, 2007 and recorded by Eugene Barsky, UBC Physiotherapy Outreach Librarian.
Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY) mRNA levels are modified by stress and glucocorticoids in rainbow trout (Oncorhynchus mykiss)
Creators: name: Doyon, Christian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Molecular.
subject: Biology, Animal Physiology.

description: The studies described in this thesis were designed to address the hypothesis that stress and glucocorticoids modify the levels of corticotropin-releasing factor (CRF) and neuropeptide Y (NPY) mRNA in the rainbow trout ( Oncorhynchus mykiss) brain. Standard cloning techniques provided the full-length cDNA sequences coding for trout NPY and two CRF paralogues. Using a ribonuclease protection assay (RPA), a tissue distribution demonstrated that both CRF paralogues are primarily abundant in the preoptic area of the trout brain, whereas NPY mRNA is more abundant in the telencephalon. The effects of social stress on CRF1 and NPY mRNA levels were examined with pairs of sized-matched juvenile female trout. After 72 h of interaction, CRF1 and NPY mRNA levels were respectively 51% and 32% higher in the preoptic area of subordinate trout. These results suggest that CRF and NPY may be involved in the control of the stress axis in trout. However, my experiments could not distinguish between the effects of stress and food deprivation. The levels of plasma cortisol in isolated trout indicated that confinement in small boxes was more stressful than isolation in a large tank. The elevation in CRF1 mRNA levels was greater and more persistent in confined fish. CRF1 mRNA levels were also elevated in trout physically disturbed to exhaustion but only after repeated chasing events. Together, these results suggest that the duration and intensity of stress are important factors determining the magnitude and persistence of the elevation in CRF mRNA levels. The effects of glucocorticoids on CRF and NPY mRNA levels were examined by exposing trout to cortisol, a glucocorticoid receptor antagonist (RU-486) or a cytochrome P450 inhibitor that blocks cortisol synthesis (metyrapone). My results suggest that glucocorticoids modify CRF1 and NPY mRNA levels but only part of the results support the presence of a glucocorticoid-induced negative feedback loop. Further studies are required to clarify the role of glucocorticoids in the regulation of the stress axis activity in fish.
Determining eligibility for antiretroviral therapy in resource-limited settings using total lymphocyte counts, hemoglobin and body mass index
Creators: name: Moore, David M.
name: Awor, Anna
name: Downing, Robert S.
name: Were, Willy
name: Solberg, Peter
name: Tu, David
name: Chan, Keith
name: Hogg, Robert S.
name: Mermin, Jonathan
Publisher: name: BioMed Central
Year: 2015

description: Background. CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. Methods We conducted a cross-sectional study of HIV-infected adults in Uganda, who presented for assessment for ART-eligibility with WHO clinical stages I, II or III. Two by two tables were constructed to examine TLC thresholds, which maximized sensitivity for CD4 cell counts ≤ 200 cells μL, while minimizing the number offered ART with counts > 350 cells μL. Hb and BMI values were then examined to try to improve model performance. Results 1787 subjects were available for analysis. Median CD4 cell counts and TLCs, were 239 cells/μL and 1830 cells/μL, respectively. Offering ART to all subjects with a TLCs ≤ 2250 cells/μL produced a sensitivity of 0.88 and a false positive ratio of 0.21. Algorithms that treated all patients with a TLC <2000 cells/μL, excluded all patients with a TLC >3000 cells/μL, and used Hb and/or BMI values to determine eligibility for those with TLC values between 2000 and 3000 cells/μL, marginally improved accuracy. Conclusion TLCs appear useful in predicting who would be eligible for ART based on CD4 cell count criteria. Hb and BMI values may be useful in prioritizing patients for ART, but did not improve model accuracy.
A barn between East Barsham and Great Snoring containing reused medieval building materials
Creators: name: Fenner, Alayne
name: Nierop-Reading, Vic
name: Smith, Diana
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 536-537
description: Description of a nineteenth-century barn, now ruinous, examined in 2002 by the Survey Team of the Norfolk Historic Buildings Group and found to contain a large number of moulded stones and stone fragments which appear to have come from a medieval church. References in nineteenth-century issues of Norfolk Archaeol indicate that the fragments may be from an earlier barn, which itself may have contained re-used material from Walsingham Priory.
A hoard of Iron Age coins discovered at Sedgeford, 2003
Creators: name: Dennis, Megan
name: Thirkettle, Ray
name: Davies, Gareth
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 538-540
description: Report on the discovery by the Sedgeford Historical and Archaeological Research Project of a hoard of thirty-nine Gallo-Belgic E gold-alloy staters in 2003. The majority of the hoard was hidden in a cow bone.
Language Evolution, Metasyntactically
Creators: name: Zaytsev, Vadim
Publisher: name: figshare
Year: 2012
Subjects: subject: Theoretical Computer Science
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: Vadim Zaytsev. Language Evolution, Metasyntactically. To appear in The Pre-proceedings of the First International Workshop on Bidirectional Transformation (BX 2012), March 2012.
Two Roman brooch finds from Hockering and Felmingham
Creators: name: Mackreth, Donald F
name: Bayley, Justine
name: Gurney, David
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 540-542
description: Description of a multiple bow brooch from Hockering, found in 2001, and of a bronze brooch-mould from Felmingham, found in 1999.
Comparison of Context-free Grammars Based on Parsing Generated Test Data
Creators: name: Zaytsev, Vadim
name: Fischer, Bernd
name: Lämmel, Ralf
Publisher: name: figshare
Year: 2012
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: Bernd Fischer, Ralf Lämmel, Vadim Zaytsev. Comparison of Context-free Grammars Based on Parsing Generated Test Data. In Uwe Aßmann, Anthony Sloane, editors, Post-proceedings of the Fourth International Conference on Software Language Engineering (SLE 2011), LNCS 6940, pages 324–343, Springer, Heidelberg, 2012.
Excavation of a ring-ditch at Hopton on Sea, 2002
Creators: name: Penn, Kenneth
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 542-545
description: Report on a ring-ditch, initially thought to have been the remains of a Bronze Age round barrow but, following excavation, believed to have been of eighteenth- or nineteenth-century construction, possibly the site of a former post-mill.
Medieval activity on the site of the former Village Hall, Little Cressingham
Creators: name: Robertson, David
name: Hobbs, Ben Phillip
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 546-548
description: Report on archaeological investigations on the site of the former Village Hall, Little Cressingham, which uncovered a series of pits, a structural feature, pottery and painted glass of medieval date.
Notation-Parametric Grammar Recovery
Creators: name: Zaytsev, Vadim
Publisher: name: figshare
Year: 2012
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: Vadim Zaytsev. Notation-Parametric Grammar Recovery. To appear in The Proceedings of the 12th International Workshop on Language Descriptions, Tools, and Applications (LDTA 2012), March 2012
L'influence de l'esprit scientifique sur la construction des droits français, anglais et québécois au sortir du siècle des lumières
Creators: name: Cabanac, Julien P
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Law.

description: L'État est apparu à la fin du 16e siècle pour stabiliser une société occidentale chaotique. Le rôle du droit, dans ce contexte, était d'abord de contribuer à la stabilité sociale. Parallelement à sa relation avec l'État, le droit a aussi été soumis à d'autres influences telles que l'évolution des moeurs ou l'évolution de la pensée. La structure du droit substantiel ne semble pas avoir changé rapidement depuis le Moyen Âge. En France, les coutumes fûrent rédigées et compilées. Quelques grandes ordonnances virent le jour, mais leur organisation était encore sommaire et la logique de leur structure était surtout énumerative. En Angleterre, les règles du droit privé présentés dans les précédents judiciaires ne semblaient pas avoir été suivies de façon rigoureuse ou systématique et encore moins théorisées dans de grands énoncés. La procédure judiciaire a été enfermée dans des règles strictes plutot imperméables aux réarrangements du droit. Le droit anglais évoluait, certes, mais toujours selon la même rationalité horizontale, compilatrice. Mais cette situation a été appelée à changer. À l'époque des Lumières, les sciences prennent de plus en plus d'espace dans l'enseignement, dans l'économie, dans la santé et surtout grandissent en popularité. Il ne s'agit plus de rationalité pure, mais d'une recherche de la connaissance du réel de façon a en échafauder la théorie et en comprendre la rationalité. La science exige un lien inductif-déductif particulier entre la rationalité et la réalite objectivee. Dans le common law anglais, la hiérarchie des tribunaux au 19e siècle se prêtait a l'érection des principes rationnels par les cours supérieures. Ces principes ont pu ensuite être mis a l'épreuve de manière déductive par les cours inférieures, mais aussi par l'ensemble de la communauté juridique. Dans les droits civilistes français et québécois, le législateur a, lui aussi, édicté les principes de droit grâce aux grandes codifications du 19e siècle. Les principes codifiés ont été, eux aussi, mis a l'épreuve par leur interprétation et leur application déductive. Ce processus, dans lequel nous reconnaissons une influence de l'esprit scientifique serait apparu tant en France qu'au Québec laissant croire qu'il s'agissait bien d'une mentalité transfrontalières. Les systèmes juridiques de la France, l'Angleterre et le Québec ont donc pu avoir intégré, à partir du 19e siècle, une façon de réfléchir et de construire le droit selon une mentalité inductive-déductive signant peut-être, par là, l'influence de l'esprit scientifique.
The National Mapping Programme in Norfolk, 2003--4
Creators: name: Tremlett, Sophie
name: Albone, J
name: Massey, Sarah
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 549-555
description: Report on progress during 2003--4 of the National Mapping Programme in mapping, recording and collating archaeological sites visible on aerial photographs in Norfolk, including a summary of mapping and results by archaeological period.
Guided Grammar Convergence
Creators: name: Zaytsev, Vadim
Publisher: name: figshare
Year: 2012
Subjects: subject: Theoretical Computer Science
subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: Vadim Zaytsev. Guided Grammar Convergence. Draft submitted to The Eighth European Conference on Modelling Foundations and Applications (ECMFA 2012), July 2012. Submitted, pending reviews.
Archaeological finds in Norfolk in 2003
Creators: name: Gurney, David
Publisher: name: Archaeology Data Service
Year: 2020

description: Norfolk Archaeology, 44 (3), 563-573
description: Report on a selection of finds out of an estimated total of around 17,000 objects seen and recorded for entry on the Norfolk Historic Environment Record during 2003. Finds are catalogued in sections according to archaeological period.