cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Advanced laser sources for industrial processing and remote sensing
Creators: name: Teppitaksak, Achaya
Publisher: name: Imperial College London
Year: 2016

description: In the fifty years since their discovery, the use of laser oscillators and amplifiers has increased to cover a wide range of applications. This thesis develops diode-pumped solid-state (DPSS) lasers for two main applications: industrial processing and remote sensing. The first half of this thesis investigates the development of bounce geometry lasers that can be used to generate high power light sources suitable for industrial processing using diode-pumped Nd:YVO4 laser sources at both 1342nm and 1064nm transitions. The first of these investigations develops bounce geometry configuration Nd:YVO4 laser sources operating at 1342nm. For continuous wave (CW) operation at powers of 15.9W with 30% optical-to-optical efficiency were achieved. For pulsed operation, Q-switching based on an acousto-optic modulator and mode-locking based on nonlinear-mirror mode-locking were demonstrated. To suit a range of different industrial applications, a versatile gain switched laser diode source at a wavelength of 1064nm was developed to have independently adjustable pulse energies, pulse duration and repetition rates. To reach a commercially useful power level, a seed laser was amplified in a master oscillator power amplifier (MOPA) configuration using two ultrahigh-gain Nd:YVO4 bounce amplifiers in series. In a first amplifier (preamplifier), a small-signal gain of ~50dB with good TEM00 beam quality preservation was achieved with 24W pumping while a second power amplifier was used to achieve an average output power of up to ~14W using an input seed power of 188mW. The second part of this thesis develops laser sources for remote sensing applications based on direct diode pumping of Alexandrite lasers in an end-pumping configuration. When compared to Q-switched Nd:YAG lasers, which are typically used for satellite based remote sensing, Alexandrite lasers have the potential to be more efficient and offer more flexible wavelength tunability. Following a broad overview of Alexandrite lasers, this thesis investigates diode-pumped Alexandrite laser performance. To achieve a high average power, a compact laser cavity was built with output power as high as 26.2W and slope efficiency of 49%. This was more than an order of magnitude higher than previously reported from diode pumped Alexandrite lasers. To achieve TEM00 laser output, many extended cavity designs were investigated. Following this, to enhance the laser efficiency, an Alexandrite laser was developed utilizing the unique characteristics of temperature-dependent gain of Alexandrite and the performance from 20-150˚C was characterised. To demonstrate high pulse energies, suitable for remote sensing applications, for the first time, a direct diode pumping Q-switched Alexandrite was demonstrated. A Q-switched output pulse energy of >1mJ at 100Hz pulse repetition rate in TEM00 mode was achieved.
Additional file 1 of Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers
Creators: name: Kang, Koung Mi
name: Byun, Min Soo
name: Lee, Jun Ho
name: Yi, Dahyun
name: Choi, Hye Jeong
name: Lee, Eunjung
name: Lee, Younghwa
name: Lee, Jun-Young
name: Kim, Yu Kyeong
name: Sohn, Bo Kyung
name: Sohn, Chul-Ho
name: Lee, Dong Young
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1. Supplementary methods (Method S1 and S2).
Associations of dietary vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12 and folate equivalent intakes with metabolic syndrome
Creators: name: Yanjun Wu
name: Suyun Li
name: Weijing Wang
name: Dongfeng Zhang
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: The study used the data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014 to analyse the relationship of dietary vitamin B1, B2, niacin, B6, B12 and dietary folate equivalent (DEF) intakes with metabolic syndrome. In the multivariate-adjusted model 2, compared with the lowest quartile of dietary intake, the odd ratios (ORs;95% confidence intervals (CIs)) were 0.73 (0.59–0.91), 0.76 (0.61–0.95), 0.76 (0.59–0.98) and 0.77 (0.62–0.96) for the highest quartile of vitamin B1, niacin, B6 and DFE, respectively. The ORs (95%CIs) for the third and the highest quartile of vitamin B2 were 0.78 (0.61–0.99) and 0.62 (0.47–0.83). A linear inverse relationship was found between dietary vitamin B1, niacin, B6, DFE and metabolic syndrome, and a non-linear inverse relationship was found between dietary vitamin B2 and metabolic syndrome. Our results suggested that higher intake of vitamin B1, B2, niacin, B6 and DFE were all associated with reduced risk of metabolic syndrome.
Holographic dark energy through Tsallis entropy
Creators: name: Saridakis, Emmanuel N.
name: Bamba, Kazuharu
name: Myrzakulov, R.
name: Anagnostopoulos, Fotios K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In order to apply holography and entropy relations to the whole universe, which is a gravitational and thus nonextensive system, for consistency one should use the generalized definition for the universe horizon entropy, namely Tsallis nonextensive entropy. We formulate Tsallis holographic dark energy, which is a generalization of standard holographic dark energy quantified by a new dimensionless parameter $δ$, possessing the latter as a particular sub-case. We provide a simple differential equation for the dark energy density parameter, as well as an analytical expression for its equation-of-state parameter. In this scenario the universe exhibits the usual thermal history, namely the successive sequence of matter and dark-energy epochs, before resulting in a complete dark energy domination in the far future. Additionally, the dark energy equation-of-state parameter presents a rich behavior and, according to the value of $δ$, it can be quintessence-like, phantom-like, or experience the phantom-divide crossing before or after the present time. Finally, we confront the scenario with Supernovae type Ia and Hubble parameter observational data, and we show that the agreement is very good, with $δ$ preferring a value slightly larger than its standard value 1.
description: 8 pages, 3 figures, version published in JCAP
New instrumentation and methods for ultrafast pump-probe spectroscopy
Creators: name: Walke, Daniel John
Publisher: name: Imperial College London
Year: 2016

description: Recent advances have led to the demonstration of trains of attosecond pulses and isolated attosecond pulses in the vacuum ultraviolet (VUV) and extreme ultraviolet (XUV) regions of the electromagnetic spectrum in a number of laboratories. This has raised the possibility of direct time resolved measurements of correlation driven electron dynamics within molecules, with a long term aim of unprecedented control over the dynamics of matter at atomic and molecular length scales. Particular interest has arisen towards the possibility of a charge migration mechanism within molecules, in which purely electron driven processes result in the movement of charge around an excited molecule in the absence of any nuclear dynamics. However, even once these sources have been established, using them in time resolved experiments is challenging. This is due to extremely short time-scales involved, the complexity of the processes under study, and the limitations of currently available attosecond sources. In this thesis I describe the development of novel instrumentation and methods for attosecond pump – probe experiments on electron dynamics in molecules. Strategies for the experimental study of charge migration are reviewed in detail which motivates the design and implementation of a purpose built instrument combining an electron velocity map imaging (VMI) spectrometer and an ion time of flight (iTOF) spectrometer. This instrument is designed in tandem with the development and characterisation of an isolated pulse at the new photon energy of 20eV. This 20eV pulse is intrinsically synchronized with another attosecond pulse at 90eV. Together, the new instrument and light source represent a unique capability for the investigation of electron dynamics in molecules. Finally, the first experimental results are presented and perspectives for future studies using the new developments are discussed.
ON THE GEOMETRY OF THE X-RAY EMITTING REGION IN SEYFERT GALAXIES
Creators: name: Stern, Boris E.
name: Poutanen, Juri
name: Svensson, Roland
name: Sikora, Marek
name: Begelman, Mitchell C.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: For the first time, detailed radiative transfer calculations of Comptonized X-ray and gamma-ray radiation in a hot pair plasma above a cold accretion disk are performed using two independent codes and methods. The simulations include both energy and pair balance as well as reprocessing of the X- and gamma-rays by the cold disk. We study both plane-parallel coronae as well as active dissipation regions having shapes of hemispheres and pill boxes located on the disk surface. It is shown, contrary to earlier claims, that plane-parallel coronae in pair balance have difficulties in selfconsistently reproducing the ranges of 2-20 keV spectral slopes, high energy cutoffs, and compactnesses inferred from observations of type 1 Seyfert galaxies. Instead, the observations are consistent with the X-rays coming from a number of individual active regions located on the surface of the disk. A number of effects such as anisotropic Compton scattering, the reflection hump, feedback to the soft photon source by reprocessing, and an active region in pair equilibrium all conspire to produce the observed ranges of X-ray slopes, high energy cutoffs, and compactnesses. The spread in spectral X-ray slopes can be due to a spread in the properties of the active regions such as their compactnesses and their elevations above the disk surface. Simplified models invoking isotropic Comptonization in spherical clouds are no longer sufficient when interpreting the data.
description: 9 pages, 3 postscript figures, figures can be obtained from the authors via e-mail: juri@astro.su.se
Genesis of the alpha beta T-cell receptor
Creators: name: Dupic, Thomas
name: Marcou, Quentin
name: Walczak, Aleksandra M.
name: Mora, Thierry
Publisher: name: arXiv
Year: 2018
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called $α$ and $β$, to recognize pathogens. Using results of high throughput sequencing and computational chain-pairing experiments of human TCR repertoires, we quantitively characterize the $αβ$ generation process. We estimate the probabilities of a rescue recombination of the $β$ chain on the second chromosome upon failure or success on the first chromosome. Unlike $β$ chains, $α$ chains recombine simultaneously on both chromosomes, resulting in correlated statistics of the two genes which we predict using a mechanistic model. We find that $\sim 28 \%$ of cells express both $α$ chains. We report that clones sharing the same $β$ chain but different $α$ chains are overrepresented, suggesting that they respond to common immune challenges. Altogether, our statistical analysis gives a complete quantitative mechanistic picture that results in the observed correlations in the generative process. We learn that the probability to generate any TCR$αβ$ is lower than $10^{-12}$ and estimate the generation diversity and sharing properties of the $αβ$ TCR repertoire.
Development of novel strategies for template-based protein structure prediction
Creators: name: Mezulis, Stefans
Publisher: name: Imperial College London
Year: 2016

description: The most successful methods for predicting the structure of a protein from its sequence rely on identifying homologous sequences with a known structure and building a model from these structures. A key component of these homology modelling pipelines is a model combination method, responsible for combining homologous structures into a coherent whole. Presented in this thesis is poing2, a model combination method using physics-, knowledge- and template-based constraints to assemble proteins using information from known structures. By combining intrinsic bond length, angle and torsional constraints with long- and short-range information extracted from template structures, poing2 assembles simplified protein models using molecular dynamics algorithms. Compared to the widely-used model combination tool MODELLER, poing2 is able to assemble models of approximately equal quality. When supplied only with poor quality templates or templates that do not cover the majority of the query sequence, poing2 significantly outperforms MODELLER. Additionally presented in this work is PhyreStorm, a tool for quickly and accurately aligning the three-dimensional structure of a query protein with the Protein Data Bank (PDB). The PhyreStorm web server provides comprehensive, current and rapid structural comparisons to the protein data bank, providing researchers with another tool from which a range of biological insights may be drawn. By partitioning the PDB into clusters of similar structures and performing an initial alignment to the representatives of each cluster, PhyreStorm is able to quickly determine which structures should be excluded from the alignment. For a benchmarking set of 100 proteins of diverse structure, PhyreStorm is capable of finding over 90% of all high-scoring structures in the PDB, and over 80% of all structures of moderate alignment score.
Whole grain consumption and human health: an umbrella review of observational studies
Creators: name: Tieri, Maria
name: Ghelfi, Francesca
name: Vitale, Marilena
name: Vetrani, Claudia
name: Marventano, Stefano
name: Lafranconi, Alessandra
name: Godos, Justyna
name: Titta, Lucilla
name: Gambera, Angelo
name: Alonzo, Elena
name: Sciacca, Salvatore
name: Riccardi, Gabriele
name: Buscemi, Silvio
name: Rio, Daniele Del
name: Sumantra Ray
name: Galvano, Fabio
name: Beck, Eleanor
name: Grosso, Giuseppe
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Whole grains have been associated with a number of health benefits. We systematically reviewed existing meta-analyses of observational studies and evaluated the level of evidence for their putative effects based on pre-selected criteria. Of the 23 included studies, we found convincing evidence of an inverse association between whole grain consumption and risk of type-2 diabetes and colorectal cancer; possible evidence of decreased risk of colon cancer and cardiovascular mortality with increased whole grain intake, as well as increased risk of prostate cancer. Limited or insufficient evidence was available for all other outcomes investigated. Overall findings are encouraging for a positive effect of whole grain consumption on certain diseases, especially highly prevalent metabolic diseases, however, uncertainty of some negative associations deserves further attention.
Evaluation of anthelmintic resistance in Oklahoma beef cattle herds and assessment of composite sampling for herd level fecal egg count reduction testing
Creators: name: Gilliam, John
name: Taylor, Jared
name: Scimeca, Ruth
Publisher: name: The Bovine Practitioner
Year: 2023
Subjects: antehelmintic resistance
beef cattle
FECR
composite

description: Beef cow-calf producers submitted fecal samples for fecal egg count reduction (FECR) tests. Anthelmintic administration practices were not controlled, and producers were encouraged to follow standard procedures for each herd. Fecal egg counts (FEC) were determined using the Wisconsin method with a
limit of detection of 1 egg per gram (EPG). Inclusion criteria included a pretreatment FEC of 25 EPG. A FECR of ≤ 90% was considered indicative of resistance. Seventeen herds submitted a total of 19 sample sets. All major classes of anthelmintics were represented except for levamisole. Injectable, pour-on
and oral as well as original label and generic products were represented. Sample sets from 3 herds were excluded from the final analysis based on inadequate pretreatment FEC. Of the 16 sample sets included in the final analysis, 13 exhibited resistance based on the arithmetic mean of individual FECR tests (FECRT). In addition to individual FEC, composite samples for each herd were created using 1 gram of feces from each animal. Four grams of each composite sample were used to determine a composite FEC. Composite samples from 13 herds were included in the final analysis and 11 of 13 exhibited resistance. There was complete agreement between the individual and composite samples for the detection of resistance. Based on the results of this small survey, apparent anthelmintic resistance appears to be widespread in beef cow-calf herds in Oklahoma. Composite sampling appears to be an effective
method for detection of herd level resistance.
description: The Bovine Practitioner, Vol. 57 No. 1 (2023)
Non-linear model and optimization method for a single-axis linear-motion energy harvester for footstep excitation
Creators: name: Struwig, Michael N.
name: Wolhuter, Riaan
name: Niesler, Thomas
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We propose and develop an electrical and mechanical system model of a single-axis linear-motion kinetic energy harvester for impulsive excitation that allows its generated load power to be numerically optimised as a function of design parameters. The device consists of an assembly of one or more spaced magnets suspended by a magnetic spring and passing through one or more coils when motion is experienced along the axis. The design parameters that can be optimised include the number of coils, the coil height, coil spacing, the number of magnets, the magnet spacing and the physical size. We use the proposed model to design optimal energy harvesters for the case of impulse-like motion like that experienced when attached to the leg of a human. We generate several optimised designs, ranked in terms of their predicted load power output. The three best designs are subsequently constructed and subjected to controlled practical evaluation while attached to the leg of a human subject. The results show that the ranking of the measured output power corresponds to the ranking predicted by the optimisation, and that the numerical model correctly Predicts the relative differences in generated power for complex motion. It is also found that all three designs far outperform a baseline design. The best energy harvesters generated an average power of 3.01mW into a 40$Ω$ test load when driven by footsteps whose measured peak impact was approximately 2.2g. With respect to the device dimensions, this corresponds to a power density of 179.380$μ\text{W/cm}^3$.
Formale Strukturrelationen dynamischer Operatoren
Creators: name: Borower, D. C.
Publisher: name: Zenodo
Year: 2025
Subjects: recursive algebra, operator axiomatics, fixpoints, emergent structure, structural stability, Zero-Time Theory, rAlgebra, recursive systems, entropy dynamics, meta-coherence, time-free physics, formal structure, axiomatic systems, machine-readable formulas, GPT-compatible notation

description:  

Das Werk ist als Band  der theoretischen Reihe zur Zero-Time Theory konzipiert. Es richtet sich an Leser:innen aus Mathematik, theoretischer Physik und formaler Systemtheorie.
Tidal tails in CDM cosmologies
Creators: name: Springel, Volker
name: White, Simon D. M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We study the formation of tidal tails in pairs of merging disk galaxies with structural properties motivated by current theories of cold dark matter (CDM) cosmologies. In a recent study, Dubinski, Mihos & Hernquist (1996) showed that the formation of prominent tidal tails can be strongly suppressed by massive and extended dark haloes. For the large halo-to-disk mass ratio expected in CDM cosmologies their sequence of models failed to produce strong tails like those observed in many well-known pairs of interacting galaxies. In order to test whether this effect can constrain the viability of CDM cosmologies, we construct N-body models of disk galaxies with structural properties derived in analogy to the analytical work of Mo, Mao & White (1998). With a series of self-consistent collisionless simulations of galaxy-galaxy mergers we demonstrate that even the disks of very massive dark haloes have no problems developing long tidal tails, provided the halo spin parameter is large enough. We show that the halo-to-disk mass ratio is a poor indicator for the ability to produce tails. Instead, the relative size of disk and halo, or alternatively, the ratio of circular velocity to local escape speed at the half mass radius of the disk are more useful criteria. This result holds in all CDM cosmologies. The length of tidal tails is thus unlikely to provide useful constraints on such models.
description: 17 pages, mn.sty, 13 included eps-figures, submitted to MNRAS
The scale of homogeneity in the local Universe with the ALFALFA catalogue
Creators: name: Avila, F.
name: Novaes, C. P.
name: Bernui, A.
name: de Carvalho, E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use the scaled counts in spherical caps $\mathcal{N}(
description: 15 pages, 7 figures
A combined X-ray and gravitational lensing study of the massive cooling-flow cluster PKS0745-191
Creators: name: Allen, S. W.
name: Fabian, A. C.
name: Kneib, J. P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present spatially-resolved X-ray spectroscopy of the X-ray luminous cluster of galaxies, PKS0745-191, using observations made with the ASCA and ROSAT satellites. The X-ray data measure the density, temperature, and metallicity profiles of the cluster gas and constrain the distribution of mass in the cluster to a radius of \sim 1.5 Mpc. We report the discovery of a bright gravitationally-lensed arc at a redshift, z_{\rm arc} = 0.433, in the cluster. This result identifies PKS0745 as the lowest-redshift cluster (z_{\rm clus} = 0.1028) known to exhibit gravitational lensing. The properties of the lensed source are consistent with an S_{\rm ab} galaxy with ongoing star formation. The projected cluster mass determined from lensing arguments is in excellent agreement with the value measured from a multiphase analysis of the X-ray data. This contrasts with previously-reported results for the clusters Abell 1689 and Abell 2218, for which discrepancies of \sim a factor 2 in the lensing and X-ray masses are observed. At both X-ray and optical wavelengths PKS0745 appears regular and dynamically relaxed. Abell 1689 and Abell 2218 exhibit more complex dynamical states, indicative of ongoing merger events. We suggest that merging activity has lead to line-of-sight mass enhancements in these systems. The X-ray spectra and images presented here confirm that PKS0745 contains one of the largest known cooling flows, with a mass deposition rate of \sim 1000 \Msunpyr.
description: uuencoded compressed postscript. The preprint is also available at http://www.ast.cam.ac.uk/preprint/PrePrint.html
CONSTRUINDO PONTES: POSSÍVEIS APROXIMAÇÕES ENTRE BELL HOOKS E EDUCAÇÃO LINGUÍSTICA CRÍTICA
Creators: name: Fernandes Baranhuke Junior, Claudio
Publisher: name: Zenodo
Year: 2025

description: Bell Hooks 4 possui uma obra bastante ampla, tanto nos temas discutidosquanto nas áreas trabalhadas. No entanto, a autora não escreveuespecificamente sobre educação linguística crítica. Assim, nosso objetivocom este texto é aproximar alguns conceitos pedagógicos de Bell Hooks(linguagem, pedagogia engajada, pensamento crítico, autorrealização eescrita) da educação linguística crítica. Para tanto, realizamos umapesquisa qualitativa de caráter bibliográfico interpretativo. Como resultadoda pesquisa, relatamos um evento de educação linguística crítica inspiradoem Bell Hooks.Palavras-chave: Bell Hooks. Educação Linguística Crítica. Conceitos.Conexões.
The development of a cellular model and mass spectrometry workflow for characterising protein tau in Alzheimer’s disease
Creators: name: Da, Zi Ran
Publisher: name: Imperial College London
Year: 2016

description: Background: Neurofibrillary tangles (NFTs) is one of the two ‘hallmarks’ of Alzheimer’s disease (AD). The main constitute of these tangles are known as the paired helical filaments (PHFs), which are essentially abnormal aggregate of microtubule associated protein Tau. It has been known for many years that the hyper-phosphorylation of protein Tau is a persistent feature in NFTs. However, whether hyper-phosphorylation of Tau is a cause or an effect to aggregation remains elusive. Mass spectrometry can now serve as an alternative to immunoblotting analysis for post translational modifications (PTM) study. Results: We developed a mass spectrometry method targeting on Tau protein for phosphorylation study. For a decent MS characterisation run, HEK 293 cells confluent in 5-10 plates (50 cm2) are required to be fed to the sample processing procedure. Typically, it takes 4-6 days to prepare the cells into MS samples. The targeting approach was able to discover peptides less intense by two orders of magnitude than that spotted using the general discovery method. The application of the targeted method on the soluble Tau recovered from HEK 293 cells allowed the solid discovery of three additional Tau phosphopeptide (only one phosphopeptide was discovered previously). Furthermore, for the development of the MS targeted method and high purity MS sample preparation, an efficient recombinant Tau protein production (in E.coli) protocol and a purification workflow for phosphorylated and untagged soluble/functional Tau protein (from HEK 293 cell line) was developed respectively. Conclusion: The Tau protein targeted MS method allows solid identification of additional phosphopeptides at two orders of magnitude lower peak intensity. The compatible purification protocol for soluble Tau could be applied to mammalian cells and tissue that expresses wild type and untagged Tau protein.
Effects of a plant-based fatty acid supplement and a powdered fruit, vegetable and berry juice concentrate on omega-3-indices and serum micronutrient concentrations in healthy subjects
Creators: name: Dams, Sebastian
name: Holasek, Sandra
name: Tsiountsioura, Melina
name: Edelsbrunner, Martin
name: Dietz, Pavel
name: Koefeler, Harald
name: Daniela-Eugenia Malliga
name: Ayse Gürbüz
name: Meier-Allard, Nathalie
name: Poncza, Brigitte
name: Lackner, Sonja
name: Schwarzenberger, Elke
name: Jansenberger, Yvonne
name: Lamprecht, Manfred
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology

description: The major aim of this controlled, randomised, open-labelled, parallel-grouped, clinical trial was to investigate whether supplementation with different dosages of omega-3 fatty acids (0.5 g/d and 1 g/d) from a plant-based fatty acid supplement affected omega-3-indices (O3I) in well-nourished, healthy people. In addition, the combined ingestion of the plant-based fatty acid supplement, together with an encapsulated fruit, vegetable and berry (FVB) juice powder concentrate, was applied in order to observe the absorption of certain micronutrients and to examine some aspects related to the safe consumption of the products. The data demonstrate that the intake of only 0.5 g/day of omega-3 fatty acids from of a vegan supplement was able to increase the O3I significantly after 8 and 16 weeks. The combined ingestion with the FVB supplement concurrently increased serum concentrations of specific vitamins and carotenoids without effects on hepatic, kidney and thyroid function or changes in blood lipids.
Habitual gait speed: a novel prognostic marker in COPD?
Creators: name: Kon, Samantha Swee Chin
Publisher: name: Imperial College London
Year: 2015

description: Forced expiatory volume in one second (FEV1) is the most widely accepted marker in COPD. However, COPD is now well recognised as a multisystem and heterogeneous disease, and it is unlikely that a single marker could reflect the complex range of observed pathophysiologic changes. Exercise intolerance is a common symptom in COPD, and reflects both lung and skeletal muscle dysfunction. Logistical issues often mean physical performance is not routinely measured objectively in all clinical settings. Gait speed is an easy, quick to perform established measure of physical performance in the elderly, and has been recommended as a “vital sign” or “global marker of well-being” that reflects biological rather than chronological age. Functional decline is common to both ageing and COPD but gait speed has not been validated in COPD. In 586 patients with stable COPD, usual gait speed over 4 metres (4MGS) had excellent reliability and showed concurrent validity with well-established measures in COPD. Stratification according to slow 4MGS identified significant impairments in exercise capacity and poor health-related quality of life. Subsequent studies showed that 4MGS was responsive to intervention with pulmonary rehabilitation (n=301) and longitudinal decline at one year (n=162). Using both distribution- and anchor-based approaches the minimum clinically important difference was estimated to be 0.11ms-1. In a cohort of patients with stable COPD (n=402), slower 4MGS was associated with significantly increased risk of all-cause mortality at three years, and provided prognostic information independent of FEV1. In a prospective cohort of 213 patients admitted to hospital with an acute exacerbation of COPD, slower 4MGS was associated with significantly increased odds of all-cause readmission at 90 days. The 4MGS is a reliable measure of physical performance that has potential utility as a simple assessment tool to provide a more comprehensive assessment of patients with COPD.
Hydrogen-promoted in-void diffusion of helium in a 3C-SiC(310) twin boundary: a first-principles study
Creators: name: Zhang, Yang
name: Tang, Xian
name: Cheng, Guodong
name: Tan, Jie
name: Wu, Feihong
name: Xie, Xiangmin
name: Zhou, Nan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Physical Sciences not elsewhere classified
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Computational Biology

description: The role of H atoms in the formation of irradiation-induced He bubbles in SiC grain boundaries (GBs) is unclear. The effects of H on the formation energies (Efs) and diffusion behaviour of He in the 3C-SiC twin boundary (TB) were studied using the density functional theory. We observed that a He atom stabilises at three typical sites in the 3C-SiC (310) TB with Efs = 1.95, 2.05, and 1.67 eV, which are significantly lower than those in the SiC grains. The addition of the H atom shifts the stable sites of He in the TB and increases Efs to 4.66, 3.96, and 5.13 eV. The minimum energy pathways for He diffusion in TB were changed by the addition of H atom. Moreover, the H atom reduces the barrier from 3.69 to 1.04 eV for the He diffusion in one TB void and increases it from 1.30 to 4.08 eV for the He diffusion between adjacent TB voids. We interpreted the above results through the Bader charge, density of states, and atomic force analysis. The results indicate that H promotes the in-void diffusion but suppresses the inter-void diffusion of He atoms in SiC GBs, which favours the aggregation and nucleation of He in SiC GBs.
Optimal coarse-grained site selection in elastic network models of biomolecules
Creators: name: Diggins, Patrick
name: Liu, Changjiang
name: Deserno, Markus
name: Potestio, Raffaello
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Elastic network models, simple structure-based representations of biomolecules where atoms interact via short-range harmonic potentials, provide great insight into a molecule's internal dynamics and mechanical properties at extremely low computational cost. Their efficiency and effectiveness have made them a pivotal instrument in the computer-aided study of proteins and, since a few years, also of nucleic acids. In general, the coarse-grained sites, i.e. those effective force centres onto which the all-atom structure is mapped, are constructed based on intuitive rules: a typical choice for proteins is to retain only the C$_α$ atoms of each amino acid. However, a mapping strategy relying only on the atom type and not the local properties of its embedding can be suboptimal compared to a more careful selection. Here we present a strategy in which the subset of atoms, each of which is mapped onto a unique coarse-grained site of the model, is selected in a stochastic search aimed at optimising a cost function. The latter is taken to be a simple measure of the consistency between the harmonic approximation of an elastic network model and the harmonic model obtained through exact integration of the discarded degrees of freedom. The method is applied to two representatives of structurally very different types of biomolecules: the protein Adenylate kinase and the RNA molecule adenine riboswitch. Our analysis quantifies the substantial impact that an algorithm-driven selection of coarse-grained sites can have on a model's properties.
UNIFICATION OF THE NEARBY AND PHOTOMETRIC STELLAR LUMINOSITY FUNCTIONS
Creators: name: Kroupa, Pavel
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We introduce a model Galactic field low-mass stellar population that has a proportion of binary systems as observed, with a mass ratio distribution consistent with observational constraints. The model single star and system luminosity function agrees with the nearby and the Malmquist corrected photometric luminosity function, respectively. We tabulate the model luminosity functions in the photometric V-, I- and K-bands, and in bolometric magnitudes. Unresolved binary systems are thus a natural explanation for the difference between the nearby and photometric luminosity functions. A local overdensity of faint stars needs not be postulated to account for the difference, and is very unlikely. We stress that the nearby luminosity function can only be used to weakly constrain the stellar mass function below $0.5\,M_\odot$, because of the small sample size. The photometric luminosity function can only be used to put lower limits on the stellar mass function because most binary systems are not resolved. However, taken together the nearby and photometric stellar luminosity function data do not imply a mass function with a peak at a mass of $0.2-0.3\,M_\odot$. Instead, the data are consistent with a power-law mass function between 0.08$\,M_\odot$ and $0.5\,M_\odot$. We urge researchers to only use star count data that are properly corrected for {\it all} contributions to cosmic scatter, photometric uncertainties, and unresolved binaries, and to be aware of the severe limitations of theoretical mass--luminosity relations for low mass stars, when drawing conclusions about structure in the stellar mass function.
description: 19 pages, plain TeX, figures available on request, to appear in Nov.1 issue of Part I of ApJ
title: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 94
Creators: name: Aubert, Eduardo Henrik
name: Brochard, Pierre
name: Aubert, Eduardo Henrik
name: Brochard, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Laboratoire de médiévistique occidentale de Paris
subject: Semur-en-Auxois
subject: LaMOP

description: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 94

production-software: eScriptorium + Kraken version 3.0.13 (PageXml)
description: Source: https://www.nakala.fr/10.34847/nkl.a018cg00
description: Source: https://www.nakala.fr/10.34847/nkl.e905tdea
description: Relation: https://lamop.hypotheses.org/
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
[IU-Bloomington] The Missing Link in Bioimage AI? Empowering Biomedical Experimental Scientists to Generate FAIR Data from the Ground Up
Creators: name: Strambio De Castillia, Caterina
Publisher: name: Zenodo
Year: 2025

description: This talk was presented on 4/25/2025 as part of the Data Science Invited Talk Series hosted by the Luddy School of Informatics, Computing, and Engineering at Indiana University Bloomington in Bloomington, Indiana.
Additional file 2 of Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers
Creators: name: Kang, Koung Mi
name: Byun, Min Soo
name: Lee, Jun Ho
name: Yi, Dahyun
name: Choi, Hye Jeong
name: Lee, Eunjung
name: Lee, Younghwa
name: Lee, Jun-Young
name: Kim, Yu Kyeong
name: Sohn, Bo Kyung
name: Sohn, Chul-Ho
name: Lee, Dong Young
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 2. Supplementary tables (Table S1, S2, and S3).
Constraints on Association of Single-pulse Gamma-ray Bursts and Supernovae
Creators: name: Norris, J. P.
name: Bonnell, J. T.
name: Watanabe, K.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We explore the hypothesis, similar to one recently suggested by Bloom and colleagues, that some nearby supernovae are associated with smooth, single-pulse gamma-ray bursts, possibly having no emission above ~ 300 keV. We examine BATSE bursts with durations longer than 2 s, fitting those which can be visually characterized as single-pulse events with a lognormal pulse model. The fraction of events that can be reliably ascertained to be temporally and spectrally similar to the exemplar, GRB 980425 - possibly associated with SN 1998bw - is 4/1573 or 0.25%. This fraction could be as high as 8/1573 (0.5%) if the dimmest bursts are included. Approximately 2% of bursts are morphologically similar to GRB 980425 but have emission above ~ 300 keV. A search of supernova catalogs containing 630 detections during BATSE's lifetime reveals only one burst (GRB 980425) within a 3-month time window and within the total 3-sigma BATSE error radius that could be associated with a type Ib/c supernova. There is no tendency for any subset of single-pulse GRBs to fall near the Supergalactic Plane, whereas SNe of type Ib/c do show this tendency. Economy of hypotheses leads us to conclude that nearby supernovae generally are not related to smooth, single-pulse gamma-ray bursts.
description: 25 pages, 5 figures
VLBI Observations of a Complete Sample of Radio Galaxies V. 3C346 and 4C31.04: two Unusual CSS Sources
Creators: name: Cotton, W. D.
name: Feretti, L.
name: Giovannini, G.
name: Venturi, T.
name: Lara, L.
name: Marcaide, J.
name: Wehrle, A. E.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present observations at 1.7 and 8.4 GHz of two Compact Steep Spectrum (CSS) sources from a complete sample of low-intermediate power radio galaxies. 3C346 shows an asymmetric structure with a one-sided ``jet'' and ``hot spot''. Present observations suggest that the classification of this source as a CSS is inappropriate, and that it is a common radio galaxy at a small angle to the line of sight. Its properties are in agreement with the predictions of unified schemes models. 4C31.04 shows more complex structure with the possibility of a centrally located flat spectrum core in between two close lobes. We suggest that this source could be a low redshift Compact Symmetric Object.
description: 15 pages, LATEX, uuenconde ps figures To be published in the Astrophysical Journal, October 20th issue
Isovector Charges of the Nucleon from 2+1+1-flavor Lattice QCD
Creators: name: Gupta, Rajan
name: Jang, Yong-Chull
name: Yoon, Boram
name: Lin, Huey-Wen
name: Cirigliano, Vincenzo
name: Bhattacharya, Tanmoy
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present high statistics results for the isovector charges $g^{u-d}_A$, $g^{u-d}_S$ and $g^{u-d}_T$ of the nucleon. Calculations were carried out on eleven ensembles of gauge configurations generated by the MILC collaboration using highly improved staggered quarks (HISQ) action with 2+1+1 dynamical flavors. These ensembles span four lattice spacings $a \approx$ 0.06, 0.09, 0.12 and 0.15 fm and light-quark masses corresponding to $M_π\approx$ 135, 225 and 315 MeV. Excited-state contamination in the nucleon 3-point correlation functions is controlled by including up to three-states in the spectral decomposition. Remaining systematic uncertainties associated with lattice discretization, lattice volume and light-quark masses are controlled using a simultaneous fit in these three variables. Our final estimates of the isovector charges in the $\overline{\text{MS}}$ scheme at 2 GeV are $g_A^{u-d} = 1.218(25)(30)$, $g_S^{u-d} = 1.022(80)(60) $ and $g_T^{u-d} = 0.989(32)(10)$. The first error includes statistical and all systematic uncertainties except that due to the extrapolation ansatz, which is given by the second error estimate. We provide a detailed comparison with the recent result of $g_A^{u-d} = 1.271(13)$ by the CalLat collaboration and argue that our error estimate is more realistic. Combining our estimate for $g_S^{u-d}$ with the difference of light quarks masses $(m_d-m_u)^{\rm QCD}=2.572(66)$ MeV given by the MILC/Fermilab/TUMQCD collaboration for 2+1+1-flavor theory, we obtain $(M_N-M_P)^{\rm QCD} = 2.63(27)$ MeV. We update the low-energy constraints on novel scalar and tensor interactions, $ε_{S}$ and $ε_{T}$, at the TeV scale by combining our new estimates for $g^{u-d}_S$ and $g^{u-d}_T$ with precision low-energy nuclear experiments, and find them comparable to those from the ATLAS and the CMS experiments at the LHC.
description: Final published version with 35 pages and 17 figures. arXiv admin note: text overlap with arXiv:1606.07049
title:  Pegasus company, un’alternativa cooperativa ai miti della Silicon Valley
Creators: name: Martinelli  , Francesca
Publisher: name: RomaTrE-Press
Year: 2020

description: Il capitolo sottolinea l’importanza delle cooperative volte alla tutela dei freelance e portando gli esempi di Doc Servizi e Coopaname. Il capitolo parte con un approfondimento delle Pegasus Companies, una vera e propria alternativa alle Unicorn Companies. Le Pegasus Companies sono delle vere e proprie piattaforme cooperative che portano un’alternativa più inclusiva all’interno della GIG economy. Le piattaforme cooperative esistono dal 2014 e sono la dimostrazione di come le cooperative sappiano adattarsi ai nuovi bisogni della società. Grazie a questa nuova forma cooperativa, internet e le piattaforme digitali diventano più accessibili, riducendo i costi di entrata e diventando così un bene comune in un’epoca sempre più digitale.
description: Cooperative bene comune
Towards a Unified Model for the `Diffuse Ionized Medium' in Normal and Starburst Galaxies
Creators: name: Wang, Jing
name: Heckman, Timothy M.
name: Lehnert, Matthew D.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyze H$α$ images and long-slit spectra of samples of normal and starburst galaxies to better understand the nature of the diffuse, low-surface-brightness gas in these galaxies. We find that in both samples there is a strong inverse correlation between the H$α$ surface-brightness ($Σ_{Hα}$) and the [SII]/H$α$ line ratio at a given location in the galaxy. However, the correlation for the starbursts is offset brightward by an order-of-magnitude in H$α$ surface-brightness at a given line ratio. In contrast, we find that all the galaxies (starburst and normal alike) define a universal relation between line ratio and the relative H$α$ surface brightness ($Σ_{Hα}/Σ_e$, where $Σ_e$ is the mean H$α$ surface brightness within the galaxy half-light radius). We show that such a universal correlation is a natural outcome of a model in which the DIM is photoionized gas that has a characteristic thermal pressure ($P$) that is proportional to the mean rate of star-formation per unit area in the galaxy ($Σ_{SFR}$). Good quantitative agreement with the data follows if we require the constant of proportionality to be consistent with the values of $P$ and $Σ_{SFR}$ in the local disk of the Milky Way. Such a scaling between $P$ and $Σ_{SFR}$ may arise either because feedback from massive stars heats the ISM or because $Σ_{SFR}$ is determined (or limited) by the mean gas pressure.
description: AASTeX style latex file, two figures
Corine Jamet-Vierny
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: 2 fichiers
description: date: start=2009-06-10;end=2016-06-14