cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Remarks about the diversity of mountain Norway spruce forest in the Sudetes, with particular reference to the Szczeliniec Massif (Stołowe Mts, Poland)
Creators: name: Reczyńska, Kamila
name: Świerkosz, Krzysztof
Publisher: name: figshare
Year: 2013
Subjects: subject: Botany
subject: Plant Biology
subject: FOS: Biological sciences

description: Abstract: Between 2011 and 2012 from all sites in the Sudetes on which Calamagrostio villosae-Piceetum has been reported so far, 56 relevés were collected according to Braun-Blanquet approach. Collected material enabled us to compare the floristic compositions of the Norway spruce forests from the Karkonosze Mts, the Śnieżnik Massif, the Orlickie Mts, the Izerskie Mts, Wielka Sowa Mt. and the highest part of the Stołowe Mts. The results of
analyses revealed that the area of Calamagrostio villosae-Piceeteum is limited to the highest part of the Sudetes and the association is well developed only in the Karkonosze Mts and the Śnieżnik Massif, with exception of single locality in the Izerskie Mts (the Płonka stream valley). The diagnostic species of this association are Homogyne alpina, Plagiothecium undulatum, Sorbus aucuparia var. glabrata, Rumex alpestris, Athyrium distentifolium, Polygonum bistorta, Gentiana asclepiadea and the differentiating species are Trientalis europaea, Polytrichum commune, Deschampsia caespitosa and Nardus stricta. The rest of earlier described localities of high-mountain Norway spruce forest (including the Szczeliniec Massif in the Stołowe Mts) probably belong to two separate associations: to the acidophilous Vaccinio
vitis-ideae-Abietetum, with occurrence of Abies alba, Betula pubescens agg. and Vaccinium vitis-idaea and to the mesotrophic Luzulo luzuloidis-Abietetum with higher abundance of Fagus sylvatica, Melandrium rubrum, Senecio ovatus and Rubus idaeus. It suggests that the phytocoenoses which have been classified so far in Poland as Abieti-Piceetum (montanum) Szaf., Pawł. & Kulcz. 1923 em. J. Mat. 1978 should be divided into two separate
associations.
title: Measurement and estimation of the flanking impact sound transmission in timber frame building constructions
Creators: name: Neusser, Maximilian
name: Bednar, Thomas
Publisher: name: TU Wien
Year: 2022
Subjects: Flanking Sound Transmission
Light weight constructions
Timber Frame Buildings

description: The Kij vibration reduction index is the essential parameter for characterizing the flanking transmission of impact sound in buildings. The calculation method according to EN ISO 12354-2 based on Kij has been established for many years for heavy homogenous constructions. For timber frame constructions, the determination of the vibration reduction index is not, with sufficient accuracy, possible. The parameter used for characterizing the flanking sound transmission in timber frame constructions to estimate the normalized flanking impact sound pressure level Ln,f is the direction-averaged vibration level difference Dv,i,j. The paper discusses the applicability of this method for timber frame constructions by comparing the measured and the predicted normalized flanking impact sound pressure level Ln,f of a timber frame T-joint. The direction-averaged vibration level difference Dv,i,j was measured in a test facility in one T-joint configuration under different loads on the joint. The measurement result was used to calculate Ln,f. The results are compared with the measurement of the normalized flanking impact sound pressure level by shielding the direct transmission path. The results show that with minor modifications of the measurement procedure, a satisfactory agreement between the prediction model of the EN ISO 12354-2 and the measurement result can be achieved.
2.7-m liquid-mirror telescope.
Creators: name: Hickson, Paul
name: Walker, Gordon A. H.
Publisher: name: Society of Photo-Optical Instrumentation Engineers (SPIE)
Year: 2011

description: An astronomical telescope employing a 2.7-meter diameter rotating liquid mercury mirror has recently begun operation at a site near Vancouver. The telescope achieves seeing-limited performance, and can detect galaxies as faint as 21st magnitude. Equipped with 2048 X 2048 pixel low-noise CCD detector, the telescope is now surveying a 20 arcmin wide strip of sky centered at +49 degree(s) declination. The CCD is operated in TDI mode, providing continuous imaging with a resolution of 0.6'/pixel and an integration time of 129 seconds. The primary scientific program of this instrument is to obtain spectral energy distributions of all objects in the survey area, by means of imaging through a series of 40 interference filters spanning the wavelength range 0.4 - 1.0 um. These data will then be used to identify and estimate redshifts for order X105 galaxies and X103 quasars. Copyright 1994 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Zarządzanie ryzykiem w tworzeniu wartości przedsiębiorstwa
Creators: name: Lech, Agnieszka
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: This report presents strategies for funding and investment companies in the industry, "Manufacture of machinery and equipment nec" in net current assets that are an excellent tool for risk management company, contributing to the increase in its value. All calculations were based on financial parameters corresponding to a particular industry and the financial statements of the acquired company.
title: Victims' Mental Maps of Institutional Response to Domestic Violence and Needs Regarding AI Chatbot
title: Public version of Deliverable D1.2 "Victims' mental maps of institutional response to DV and needs regarding AI Chatbot"
titleType: Subtitle
Creators: name: Tananau Blumenschein, Emanuel
name: Hopf, Stefan
name: Leonhardmair, Norbert
name: Vogt, Catharina
name: Kersten, Joachim
name: Köpsel, Natalie
name: González Cabezas, Sandra
name: Hellbernd, Hilde
name: May, Angelika
name: Mela, Marianne
name: Nipuli, Suvi
name: Romero Gutierrez, Lorea
name: Vassileva, Margarita
Publisher: name: Zenodo
Year: 2023
Subjects: Domestic Violence

description: The purpose of conducting interviews with victim-survivors of domestic violence (DV) within the framework of the IMPROVE project was to identify obstacles and barriers they have encountered to access the services of frontline responder organisations.

Obstacles and barriers refer to any internal state as well as their relationship to the external environment, which deterred them, delayed them, or created hurdles to look for and seek help out of their painful situation. Furthermore, focusing on victim-survivors who have successfully accessed frontline responder (FLR) services provides an opportunity to further explore strategies for overcoming such barriers. These range from changes in believes about themselves, their situation, or their social context and the services themselves; attitudes and expectations towards people who are victimised, seek help, as well as towards the services and their impact on them and their situation; motivations to seek help; considerations and decisions to do so.

This investigation complements the factors identified in IMPROVE deliverable D1.1 "Factors leading to low reporting and restricting access to service" and indicates important changes within the person or of their view of the services which made them get external help.

This knowledge will feature into the development of training contents in IMPROVE work package WP3 "Building capacity in FLR organisations through training" and the suggestions and tools on how to implement changes in frontline responder organisations. In addition, the interviews investigate knowledge, attitudes, and expectations toward the development an AI Chatbot to guide the development in IMPROVE work package WP2 "Conversational AI tool prototype to support domestic violence experiencers".
Contrast-enhanced CT techniques and MRI perform equally well in arthritis imaging of the hand: a prospective diagnostic accuracy study
Creators: name: Ulas, Sevtap Tugce
name: Ziegeler, Katharina
name: Richter, Sophia-Theresa
name: Ohrndorf, Sarah
name: Biesen, Robert
name: Proft, Fabian
name: Poddubnyy, Denis
name: Diekhoff, Torsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Computed tomography
subject: Dual energy
subject: Arthritis, rheumatoid
subject: Magnetic resonance imaging
subject: Ultrasound
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To investigate the performance of dual-energy CT (DECT)-generated iodine maps (iMap) and CT subtraction (CT-S) in the detection of synovitis, tenosynovitis, and peritendonitis/paratenonitis compared to magnetic resonance imaging (MRI) using musculoskeletal ultrasound (MSUS) as standard of reference. Methods: This IRB-approved prospective study consecutively investigated patients with undifferentiated arthritis. All patients underwent MSUS, MRI and contrast-enhanced DECT of the hand; from the latter conventional CT-S, image-based iMap (iMap-I) and raw data-based iMap (iMap-RD) were reconstructed. CT and MRI datasets were scored for synovitis and tenosynovitis/paratenonitis applying the modified Rheumatoid Arthritis MRI Score (RAMRIS). Sensitivity, specificity, and diagnostic accuracy were calculated. Non-inferiority was tested using the one-tailed McNemar test. Correlation of sum scores was assessed using Pearson's test. Interreader reliability was assessed using Cohen's kappa. Results: Overall, 33 patients were included. MSUS was positive for synovitis and tenosynovitis/paratenonitis in 28 patients with a sum score of 6.91. Excellent correlation with MSUS was shown for CT-S (sum score 6.38; r = 0.91), iMap-RD (sum score 9.74; r = 0.82), MRI (sum score 12.70; r = 0.85), and iMap-I (sum score 6.94; r = 0.50). CT-S had the highest diagnostic accuracy of 83%, followed by iMap-I (78%), MRI (75%), and iMap-RD (74%). All modalities showed non-inferiority. Reader agreement was good for CT-S and MRI (kappa = 0.62; 0.64) and fair for iMap-RD and iMap-I (kappa = 0.31; 0.37). Conclusion: CT-S and iMap allow highly standardized arthritis imaging and are suitable for clinical practice. MSUS still has the highest availability for arthritis imaging and served as gold standard for this study.
Transmission ratio distortion of mutations in the master regulator of centriole biogenesis PLK4
Creators: name: Neitzel, Heidemarie
name: Varon, Raymonda
name: Chughtai, Sana
name: Dartsch, Josephine
name: Dutrannoy-Tönsing, Véronique
name: Nürnberg, Peter
name: Nürnberg, Gudrun
name: Schweiger, Michal
name: Digweed, Martin
name: Hildebrand, Gabriele
name: Hackmann, Karl
name: Holtgrewe, Manuel
name: Sarioglu, Nanette
name: Schulze, Bernt
name: Horn, Denise
name: Sperling, Karl
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Centrioles / metabolism
subject: Humans
subject: Mutation
subject: Protein Serine-Threonine Kinases
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The evolutionary conserved Polo-like kinase 4 (PLK4) is essential for centriole duplication, spindle assembly, and de novo centriole formation. In man, homozygous mutations in PLK4 lead to primary microcephaly, altered PLK4 expression is associated with aneuploidy in human embryos. Here, we report on a consanguineous four-generation family with 8 affected individuals compound heterozygous for a novel missense variant, c.881 T > G, and a deletion of the PLK4 gene. The clinical phenotype of the adult patients is mild compared to individuals with previously described PLK4 mutations. One individual was homozygous for the variant c.881G and phenotypically unaffected. The deletion was inherited by 14 of 16 offspring and thus exhibits transmission ratio distortion (TRD). Moreover, based on the already published families with PLK4 mutations, it could be shown that due to the preferential transmission of the mutant alleles, the number of affected offspring is significantly increased. It is assumed that reduced expression of PLK4 decreases the intrinsically high error rate of the first cell divisions after fertilization, increases the number of viable embryos and thus leads to preferential transmission of the deleted/mutated alleles.
Spinal infection with intraspinal abscess or empyema and acute myelopathy: comparative analysis of diagnostics, therapy, complications and outcome in primary care
Creators: name: Kreutzträger, Martin
name: Lübstorf, Tom
name: Ekkernkamp, Axel
name: Blex, Christian
name: Schwab, Jan M.
name: Kopp, Marcel A.
name: Auhuber, Thomas
name: Wüstner, Grit
name: Liebscher, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Spondylodiscitis
subject: Spinal surgery
subject: Intra-spinal empyema
subject: Intra-spinal abscess
subject: Acute spinal cord injury
subject: Treatment costs
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: This study on pyogenic spinal infections with intraspinal epidural involvement (PSI +) compared the outcome of patients with spinal cord injury (SCI) to those without (noSCI) taking diagnostic algorithm, therapy, and complications into account. Methods: Patients were enrolled in an ambispective study (2012-2017). Diagnostic and therapeutic algorithms, complications, and neurological outcome were analyzed descriptively. Survival was analyzed applying Kaplan-Meier method and Cox regression. Results: In total, 134 patients with a median (IQR) age of 72 (61-79) years were analyzed. Baseline characteristics were similar between the SCI (n = 55) and noSCI (n = 79). A higher percentage of endocarditis (9% vs. 0%; p = 0.03) was detected in the noSCI group. The majority (81%) received combinatorial therapy including spinal surgery and antibiotic treatment. The surgery complication rate was 16%. At discharge, improvement in neurologic function was present in 27% of the SCI patients. Length of stay, duration of ventilation and the burden of disease-associated complications were significantly higher in the SCI group (e.g., urinary tract infection, pressure ulcers). Lethality risk factors were age (HR 1.09, 95% CI 1.02-1.16, p = 0.014), and empyema/abscess extension (>= 3 infected spinal segments, HR 4.72, 95% CI 1.57-14.20, p = 0.006), dominating over additional effects of Charlson comorbidity index, SCI, and type of treatment. The overall lethality rate was 11%. Conclusion: PSI + are associated with higher in-hospital mortality, particularly when multiple spinal segments are involved. However, survival is similar with (SCI) or without myelopathy (noSCI). If SCI develops, the rate of disease complications is higher and early specialized SCI care might be substantial to reduce complication rates.
Deep learning reconstruction improves radiomics feature stability and discriminative power in abdominal CT imaging: a phantom study
Creators: name: Michallek, Florian
name: Genske, Ulrich
name: Niehues, Stefan Markus
name: Hamm, Bernd
name: Jahnke, Paul
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Tomography
subject: X-ray computed
subject: Phantoms, imaging
subject: Liver neoplasms
subject: Algorithms
subject: Reproducibility of results
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To compare image quality of deep learning reconstruction (AiCE) for radiomics feature extraction with filtered back projection (FBP), hybrid iterative reconstruction (AIDR 3D), and model-based iterative reconstruction (FIRST). Methods: Effects of image reconstruction on radiomics features were investigated using a phantom that realistically mimicked a 65-year-old patient's abdomen with hepatic metastases. The phantom was scanned at 18 doses from 0.2 to 4 mGy, with 20 repeated scans per dose. Images were reconstructed with FBP, AIDR 3D, FIRST, and AiCE. Ninety-three radiomics features were extracted from 24 regions of interest, which were evenly distributed across three tissue classes: normal liver, metastatic core, and metastatic rim. Features were analyzed in terms of their consistent characterization of tissues within the same image (intraclass correlation coefficient >= 0.75), discriminative power (Kruskal-Wallis test p value < 0.05), and repeatability (overall concordance correlation coefficient >= 0.75). Results: The median fraction of consistent features across all doses was 6%, 8%, 6%, and 22% with FBP, AIDR 3D, FIRST, and AiCE, respectively. Adequate discriminative power was achieved by 48%, 82%, 84%, and 92% of features, and 52%, 20%, 17%, and 39% of features were repeatable, respectively. Only 5% of features combined consistency, discriminative power, and repeatability with FBP, AIDR 3D, and FIRST versus 13% with AiCE at doses above 1 mGy and 17% at doses >= 3 mGy. AiCE was the only reconstruction technique that enabled extraction of higher-order features. Conclusions: AiCE more than doubled the yield of radiomics features at doses typically used clinically. Inconsistent tissue characterization within CT images contributes significantly to the poor stability of radiomics features.
Zarządzanie Ryzykiem W Tworzeniu Wartości Na Przykładzie Przedsiębiorstwa Z Branży Spożywczej (Risk Managment in Creating Value of Company in Example of Food Production Branch Companies)
Creators: name: Michał Pilecki
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: Presented report provides value management methods through management of assets and liabilities.
PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients
Creators: name: Picker-Minh, Sylvie
name: Luperi, Ilaria
name: Ravindran, Ethiraj
name: Kraemer, Nadine
name: Zaqout, Sami
name: Stoltenburg-Didinger, Gisela
name: Ninnemann, Olaf
name: Hernandez-Miranda, Luis R.
name: Mani, Shyamala
name: Kaindl, Angela M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: PTRH2
subject: Purkinje cells
subject: Ataxia
subject: Cell survival
subject: mTOR
subject: IMNEPD
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Hom ozygous variants in the peptidyl-tRNA hydrolase 2 gene (PTRH2) cause infantile-onset multisystem neurologic, endocrine, and pancreatic disease. The objective is to delineate the mechanisms underlying the core cerebellar phenotype in this disease. For this, we generated constitutive (Ptrh2LoxPxhCMVCre, Ptrh2−/− mice) and Purkinje cell (PC) specific (Ptrh2LoxPxPcp2Cre, Ptrh2ΔPCmice) Ptrh2 mutant mouse models and investigated the effect of the loss of Ptrh2 on cerebellar development. We show that Ptrh2−/− knockout mice had severe postnatal runting and lethality by postnatal day 14. Ptrh2ΔPC PC specific knockout mice survived until adult age; however, they showed progressive cerebellar atrophy and functional cerebellar deficits with abnormal gait and ataxia. PCs of Ptrh2ΔPC mice had reduced cell size and density, stunted dendrites, and lower levels of ribosomal protein S6, a readout of the mammalian target of rapamycin pathway. By adulthood, there was a marked loss of PCs. Thus, we identify a cell autonomous requirement for PTRH2 in PC maturation and survival. Loss of PTRH2 in PCs leads to downregulation of the mTOR pathway and PC atrophy. This suggests a molecular mechanism underlying the ataxia and cerebellar atrophy seen in patients with PTRH2 mutations leading to infantile-onset multisystem neurologic, endocrine, and pancreatic disease.
Single-image wavefront curvature sensing.
Creators: name: Hickson, Paul
name: Burley, Gregory S.
Publisher: name: Society of Photo-Optical Instrumentation Engineers (SPIE)
Year: 2011

description: A single defocused star image contains sufficient information to uniquely determine the spatial phase fluctuations of the incident wavefront. A sensor which responds to the intensity distribution in the image produces signals proportional to the wavefront curvature within the pupil and the radial slope at the pupil boundary. Unlike Roddier's differential curvature sensing technique, a single-image sensor does not cancel intensity fluctuations due to atmospheric scintillation. However, it has been shown that at typical astronomical sites the scintillation signal is negligibly small. A single-image curvature sensor can theoretically achieve a signal-to-noise ratio of order Q approximately equals r20/(lambda) z0 where r0 is Fried's correlation length, (lambda) is the wavelength, and z0 is the root-mean-square distance through the atmosphere, weighted by the refractive index structure constant C2n. This is more than adequate for AO systems whenever D/r0 <EQ Q6/5. Such a sensor can be very simple, optically and mechanically, and has lower detector read noise than a comparable differential system. The concept has been tested in the laboratory by introducing, and detecting, spherical aberration in a simple optical system. Copyright 1994 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Evaluation Of Bacterial Leaf Blight Of Rice Using Hyperspectral Data
Creators: name: Hongo, C
name: Takahashi, Y
name: Sigit, G
name: Tamura, E
Publisher: name: Zenodo
Year: 2017

description: Bacterial blight is one of the most serious diseases of rice. Yield loss due to bacterial blight can be as much as 70% when susceptible varieties are grown in environments favorable to the disease. The Government of Indonesia has launched agricultural insurance program since 2013 for damage of rice by drought, flood and pest and disease. A key in agricultural insurance is damage assessment which is required to be as precise, quick, quantitative and inexpensive as possible. Conventional method is to inspect the damage by human eyes of specialist having experiences. This method, however, costs much and is difficult to estimate the infected field precisely in wide area. So there is increasing need to develop effective, simplified and low cost method using remote sensing and GIS. With this background, we conducted research on development of new method using remote sensing data for evaluation of damage ratio caused by pest and disease in West Java, Indonesia. In our research, hyperspectral data was acquired using a handheld spectroradiometer. The measurement was made just before harvesting of rice. In addition, 4 specialists conducted the eye inspection and collected data on the infection ratio.

In our analysis work, firstly, the first differential of the hyperspectral data was calculated to extract information on the red edge which shows sharp increase of reflectance in between visible and infrared wave lengths. As a result, 2 peaks on the differential curve were found near 720nm. In the same manner, the green edge was analyzed with the result that negative correlation was confirmed between the BLB infection ratio and the first differential value (R2=0.59). Then, judgement about BLB was tried through logistic regression analysis using an indicator of GMRE (Green edge multiplied red edge). The result showed that the judgement about infection by BLB was possible at 5 %significant level. Finally the study to check if GMRE could be applied to wider area was conducted using the RapidEye data. Positive result was obtained using GMRE derived from green band and red edge.

This study result suggests that the method using the green edge and red age is effective for BLB judgement and can be applied to wide area, considering the change of leaf color from green to yellow orange then to off-white white, brown and finally decolored.
Yttrium-90 radioembolization for unresectable hepatocellular carcinoma: predictive modeling strategies to anticipate tumor response and improve patient selection
Creators: name: Lüdemann, Willie
name: Kahn, Johannes
name: Pustelnik, Daniel
name: Hardt, Juliane
name: Böning, Georg
name: Jonczyk, Martin
name: Amthauer, Holger
name: Gebauer, Bernhard
name: Hamm, Bernd
name: Wieners, Gero
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Carcinoma, hepatocellular
subject: Treatment outcome
subject: Survival analysis
subject: Tumor burden
subject: Yttrium radioisotopes
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: This study aims to better characterize potential responders of Y-90-radioembolization at baseline through analysis of clinical variables and contrast enhanced (CE) MRI tumor volumetry in order to adjust therapeutic regimens early on and to improve treatment outcomes. Methods: Fifty-eight HCC patients who underwent Y-90-radioembolization at our center between 10/2008 and 02/2017 were retrospectively included. Pre- and post-treatment target lesion volumes were measured as total tumor volume (TTV) and enhancing tumor volume (ETV). Survival analysis was performed with Cox regression models to evaluate 65% ETV reduction as surrogate endpoint for treatment efficacy. Univariable and multivariable logistic regression analyses were used to evaluate the combination of baseline clinical variables and tumor volumetry as predictors of >= 65% ETV reduction. Results: Mean patients' age was 66 (SD 8.7) years, and 12 were female (21%). Sixty-seven percent of patients suffered from liver cirrhosis. Median survival was 11 months. A threshold of >= 65% in ETV reduction allowed for a significant (p = 0.04) separation of the survival curves with a median survival of 11 months in non-responders and 17 months in responders. Administered activity per tumor volume did predict neither survival nor ETV reduction. A baseline ETV/TTV ratio greater than 50% was the most important predictor of arterial devascularization (odds ratio 6.3) in a statistically significant (p = 0.001) multivariable logistic regression model. The effect size was strong with a Cohen's f of 0.89. Conclusion: We present a novel approach to identify promising candidates for Y-90 radioembolization at pre-treatment baseline MRI using tumor volumetry and clinical baseline variables.
Fractal analysis improves tumour size measurement on computed tomography in pancreatic ductal adenocarcinoma: comparison with gross pathology and multi-parametric MRI
Creators: name: Michallek, Florian
name: Haouari, Mohamed Amine
name: Dana, Ophélie
name: Perrot, Antoine
name: Silvera, Stéphane
name: Dallongeville, Axel
name: Dewey, Marc
name: Zins, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Carcinoma
subject: Pancreatic ductal
subject: Four-dimensional computed tomography
subject: Multi-parametric magnetic resonance imaging
subject: Perfusion imaging
subject: Fractals
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Tumour size measurement is pivotal for staging and stratifying patients with pancreatic ductal adenocarcinoma (PDA). However, computed tomography (CT) frequently underestimates tumour size due to insufficient depiction of the tumour rim. CT-derived fractal dimension (FD) maps might help to visualise perfusion chaos, thus allowing more realistic size measurement. Methods: In 46 patients with histology-proven PDA, we compared tumour size measurements in routine multiphasic CT scans, CT-derived FD maps, multi-parametric magnetic resonance imaging (mpMRI), and, where available, gross pathology of resected specimens. Gross pathology was available as reference for diameter measurement in a discovery cohort of 10 patients. The remaining 36 patients constituted a separate validation cohort with mpMRI as reference for diameter and volume. Results: Median RECIST diameter of all included tumours was 40 mm (range: 18-82 mm). In the discovery cohort, we found significant (p = 0.03) underestimation of tumour diameter on CT compared with gross pathology (Delta diameter(3D) = -5.7 mm), while realistic diameter measurements were obtained from FD maps (Delta diameter(3D) = 0.6 mm) and mpMRI (Delta diameter(3D) = -0.9 mm), with excellent correlation between the two (R-2 = 0.88). In the validation cohort, CT also systematically underestimated tumour size in comparison to mpMRI (Delta diameter(3D) = -10.6 mm, Delta volume = -10.2 mL), especially in larger tumours. In contrast, FD map measurements agreed excellently with mpMRI (Delta diameter(3D) = +1.5 mm, Delta volume = -0.6 mL). Quantitative perfusion chaos was significantly (p = 0.001) higher in the tumour rim (FDrim = 4.43) compared to the core (FDcore = 4.37) and remote pancreas (FDpancreas = 4.28). Conclusions: In PDA, fractal analysis visualises perfusion chaos in the tumour rim and improves size measurement on CT in comparison to gross pathology and mpMRI, thus compensating for size underestimation from routine CT.
Computed tomography angiography versus Agatston score for diagnosis of coronary artery disease in patients with stable chest pain: individual patient data meta-analysis of the international COME-CCT Consortium
Creators: name: Wieske, Viktoria
name: Walther, Mario
name: Dubourg, Benjamin
name: Alkadhi, Hatem
name: Nørgaard, Bjarne L.
name: Meijs, Matthijs F. L.
name: Diederichsen, Axel C. P.
name: Wan, Yung-Liang
name: Mickley, Hans
name: Nikolaou, Konstantin
name: Shabestari, Abbas A.
name: Halvorsen, Bjørn A.
name: Martuscelli, Eugenio
name: Sun, Kai
name: Herzog, Bernhard A.
name: Marcus, Roy P.
name: Leschka, Sebastian
name: Garcia, Mario J.
name: Ovrehus, Kristian A.
name: Knuuti, Juhani
name: Mendoza-Rodriguez, Vladymir
name: Bettencourt, Nuno
name: Muraglia, Simone
name: Buechel, Ronny R.
name: Kaufmann, Philipp A.
name: Zimmermann, Elke
name: Tardif, Jean-Claude
name: Budoff, Matthew J.
name: Schlattmann, Peter
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Computed tomography angiography
subject: Coronary angiography
subject: Coronary artery disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: There is conflicting evidence about the comparative diagnostic accuracy of the Agatston score versus computed tomography angiography (CTA) in patients with suspected obstructive coronary artery disease (CAD). Purpose: To determine whether CTA is superior to the Agatston score in the diagnosis of CAD. Methods: In total 2452 patients with stable chest pain and a clinical indication for invasive coronary angiography (ICA) for suspected CAD were included by the Collaborative Meta-analysis of Cardiac CT (COME-CCT) Consortium. An Agatston score of > 400 was considered positive, and obstructive CAD defined as at least 50% coronary diameter stenosis on ICA was used as the reference standard. Results: Obstructive CAD was diagnosed in 44.9% of patients (1100/2452). The median Agatston score was 74. Diagnostic accuracy of CTA for the detection of obstructive CAD (81.1%, 95% confidence interval [CI]: 77.5 to 84.1%) was significantly higher than that of the Agatston score (68.8%, 95% CI: 64.2 to 73.1%, p < 0.001). Among patients with an Agatston score of zero, 17% (101/600) had obstructive CAD. Diagnostic accuracy of CTA was not significantly different in patients with low to intermediate (1 to < 100, 100-400) versus moderate to high Agatston scores (401-1000, > 1000). Conclusions: Results in our international cohort show CTA to have significantly higher diagnostic accuracy than the Agatston score in patients with stable chest pain, suspected CAD, and a clinical indication for ICA. Diagnostic performance of CTA is not affected by a higher Agatston score while an Agatston score of zero does not reliably exclude obstructive CAD.
Additional file 1 of Assessing the impact of including variation in general population mortality on standard errors of relative survival and loss in life expectancy
Creators: name: Leontyeva, Yuliya
name: Bower, Hannah
name: Gauffin, Oskar
name: Lambert, Paul C
name: Andersson, Therese M.-L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Additional file 1 Estimates of 5-year RS and LLE for setting 2 and scenarios F-H for the Gotland region.
title: Incorporating terrestrial invertebrates in conservation planning
title: diversity, distribution and cross-taxon congruence in an Australian tropical savanna landscape
titleType: Subtitle
Creators: name: Oberprieler, Stefanie
Publisher: name: Charles Darwin University
Year: 2019

description: Invertebrates constitute 80% of species diversity as well as the majority of species lost under the current global extinction crisis. Still, they continue to be largely overlooked in conservation planning, primarily owing to their vast diversity and the lack of information on their distribution patterns. This thesis aims to improve our understanding of terrestrial invertebrate diversity and distribution and to identify practical and robust ways of documenting their diversity patterns in the context of conservation planning. It uses a collection developed from three decades of extensive surveys across Australia’s Monsoonal Tropics to document high levels of regional endemism and remarkable levels of diversity in the ecologically dominant terrestrial invertebrate group, ants. This includes the first comprehensive species compilation and biogeographical analysis of a large tropical region, as well as the use of an integrative approach to species delimitation to reveal extensive unrecognised diversity in six ant taxa currently recognised as single species occurring throughout the Monsoonal Tropics. It then uses data on 12 invertebrate families (comprising ants, beetles, flies and spiders) sampled in pitfall traps from 78 sites in the contiguous Kakadu and Nitmiluk National Parks to address the effectiveness of the ‘umbrella’ value of vertebrates, simplified invertebrate sampling and the selection of representative taxa for targeted assessment of invertebrate diversity. It found that vertebrates were poor ‘umbrellas’ for invertebrates, that invertebrate by-catch from vertebrate pitfall traps provided useful information on patterns of diversity and distribution for some invertebrate groups, and that ants, carabid and tenebrionid beetles and zodariid spiders were collectively the most effective target taxa for representing the broad range of invertebrate spatial patterns. These findings have two important implications. First, they highlight the very significant but under-appreciated conservation value of the invertebrate fauna of Australia’s Monsoonal Tropics. Second, they demonstrate that conservation planning for all biodiversity requires the incorporation of invertebrates into faunal surveys and that this is highly feasible.
Additional file 2 of Assessing the impact of including variation in general population mortality on standard errors of relative survival and loss in life expectancy
Creators: name: Leontyeva, Yuliya
name: Bower, Hannah
name: Gauffin, Oskar
name: Lambert, Paul C
name: Andersson, Therese M.-L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Additional file 2 Estimates of 5-year RS and LLE for setting 2 and scenario J for the Gotland region.
Sourcing and long-range transport of particulate organic matter in river bedload: Río Bermejo, Argentina
Creators: name: Dosch, Sophia
name: Hovius, Niels
name: Repasch, Marisa
name: Scheingross, Joel
name: Turowski, Jens M.
name: Tofelde, Stefanie
name: Rach, Oliver
name: Sachse, Dirk
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: river bedload
subject: particulate organic matter
subject: long-range transport
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: Fluvial transport of organic carbon from the terrestrial biosphere to the oceans is an important term in the global carbon cycle. Traditionally, the long-term burial flux of fluvial particulate organic carbon (POC) is estimated using river suspended sediment flux; however, organic carbon can also travel in river bedload as coarse particulate organic matter (POM Bed). Estimates of fluvial POC export to the ocean are highly uncertain because few studies document POM bedsources, flux, and evolution during long-range fluvial transport from uplands to ocean basins. This knowledge gap limits our ability to determine the global terrestrial organic carbon burial flux. In this study we investigate the flux, sources, and transformations of POM Bedduring fluvial transport over a ∼1300km long reach of the Río Bermejo, Argentina, which has no tributary inputs. To constrain sourcing of POM Bed, we analyzed the composition and stable hydrogen and carbon isotope ratios ( δ2H, δ13C) of plant wax biomarkers from POM Bedat six locations along the Río Bermejo and compared this to samples of suspended sediment, soil, leaf litter, and floating organic debris (POM float) from both the lowland and headwater river system. Across all samples, we found no discernible differences in n-alkane average chain length or nC29 δ13C, indicting a common origin for all sampled POM Bed. Leaf litter and POM floatnC29 δ2H values decrease with elevation, making it a useful proxy for POM Bedsource elevation. Biomarker δ2H values suggest that POM Bedis a mix of distally derived headwater and locally recruited floodplain sources at all sampling locations. These results indicate that POM Bedcan be preserved during transport through lowland rivers for hundreds of kilometers. However, the POM Bedflux decreases with increasing transport distance, suggesting mechanical comminution of these coarse organic particles and progressive transfer into the suspended load. Our provisional estimates suggest that the carbon flux from POM Bedcomprises less than 1 % of the suspended load POC flux in the Río Bermejo. While this represents a small portion of the river POC flux, this coarse, high-density material likely has a higher probability of deposition and burial in sedimentary basins, potentially allowing it to be more effective in long-term CO 2drawdown relative to fine suspended particles. Because the rate and ratio of POM Bedtransport versus comminution likely vary across tectonic and climatic settings, additional research is needed to determine the importance of POM Bedin the global carbon cycle.
Additional file 3 of Assessing the impact of including variation in general population mortality on standard errors of relative survival and loss in life expectancy
Creators: name: Leontyeva, Yuliya
name: Bower, Hannah
name: Gauffin, Oskar
name: Lambert, Paul C
name: Andersson, Therese M.-L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Additional file 3 Graphical comparisons of the bootstrap-based and conventional estimates of 5-year RS, LLE and their CIs for all scenarios.
Proficiency testing of PIK3CA mutations in HR+/HER2-breast cancer on liquid biopsy and tissue
Creators: name: Vollbrecht, Claudia
name: Hoffmann, Inga
name: Lehmann, Annika
name: Merkelbach-Bruse, Sabine
name: Fassunke, Jana
name: Wagener-Ryczek, Svenja
name: Ball, Markus
name: Dimitrova, Lora
name: Hartmann, Arndt
name: Stöhr, Robert
name: Erber, Ramona
name: Weichert, Wilko
name: Pfarr, Nicole
name: Bohlmann, Lisa
name: Jung, Andreas
name: Dietmaier, Wolfgang
name: Dietel, Manfred
name: Horst, David
name: Hummel, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: PIK3CA
subject: Breast cancer
subject: Liquid biopsy
subject: Proficiency testing
subject: Alpelisib
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Precision oncology based on specific molecular alterations requires precise and reliable detection of therapeutic targets in order to initiate the optimal treatment. In many European countries-including Germany-assays employed for this purpose are highly diverse and not prescribed by authorities, making inter-laboratory comparison difficult. To ensure reproducible molecular diagnostic results across many laboratories and different assays, ring trials are essential and a well-established tool. Here, we describe the design and results of the ring trial for the detection of therapeutically relevant PIK3CA hotspot mutations in HR+/HER2-breast cancer tissue and liquid biopsy (LB). For PIK3CA mutation detection in tissue samples, 43 of the 54 participants (80%) provided results compliant with the reference values. Participants using NGS-based assays showed higher success rate (82%) than those employing Sanger sequencing (57%). LB testing was performed with two reference materials differing in the length of the mutated DNA fragments. Most participants used NGS-based or commercial realtime PCR assays (70%). The 167 bp fragments led to a successful PIK3CA mutation detection by only 31% of participants whereas longer fragments of 490 bp were detectable even by non-optimal assays (83%). In conclusion, the first ring trial for PIK3CA mutation detection in Germany showed that PIK3CA mutation analysis is broadly established for tissue samples and that NGS-based tests seem to be more suitable than Sanger sequencing. PIK3CA mutation detection in LB should be carried out with assays specifically designed for this purpose in order to avoid false-negative results.
“Like one part of a puzzle” — individualized aromatherapy for women with gynecological cancers in aftercare: results from a qualitative-focused mixed-methods study
Creators: name: Czakert, Judith
name: Stritter, Wiebke
name: Blakeslee, Sarah B.
name: Grabowski, Jacek P.
name: Sehouli, Jalid
name: Seifert, Georg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: Integrative oncology
subject: Symptom control
subject: Gynecological cancer
subject: Breast cancer
subject: Cancer survivors
subject: Long-term care
subject: Aftercare
subject: Aromatherapy
subject: Essential oil
subject: Cancer burden
subject: Qualitative research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Gynecological cancer(s), including breast cancer patients in aftercare and survivors, need supportive strategies to cope with symptoms that are adapted to their individual needs and circumstances. Aromatherapy has potential to be such strategy, but (qualitative) empirical research taking users’ own views into consideration about the potential and challenge of aromatherapy is lacking. Purpose: The purpose of the study is to gain insights from individualized aromatherapy as a supportive care treatment, regarding their use and evaluation by women with gynecological cancers in aftercare. Methods: We conducted a study with a mixed-methods design, focused on qualitative research. Five essential oil products were given to 18 participants to apply individually over a 4-week period. After the intervention, qualitative semi-structured interviews were conducted. Further, we documented and assessed symptomatic burdens of the women (MYMOP2) before and after intervention quantitatively. Results: Aromatherapy was customized by the participants according to their needs. It showed potential for relief of symptomatic burdens — especially nausea, peripheral neuropathy, pain, and sleep. Additionally, opportunities emerged to indirectly affect symptomatic burdens. These developed out of new coping strategies (e.g., sleep routines) or by combining with existing strategies (e.g., meditation). Furthermore, aromatherapy was successfully used to promote well-being and encourage mindfulness. Conclusion: Our findings demonstrated the potential of aromatherapy as a supportive treatment modality that can be used as a kind of toolbox. Challenges, such as individual odor aversions and intolerances, and limitations due to medication or illness should be considered in future aromatherapy research.
Notes on Free Banking in Canada in the 1830s
Creators: name: Shearer, Ronald Alexander, 1932-
Publisher: name: The University of British Columbia
Year: 2017

description: Adam Shortt referred to the mid to late 1830s as "one of the most exciting and abnormal periods in Canadian political and financial history." (Shortt, 1986, 830). It may also have been decisive in setting the course of Canadian banking policy for decades. There were several important developments: the chartering of new banks and increases in the capital of existing chartered banks; attempts to obtain charters for new banks on different principles than those of the existing institutions; the establishment of non-chartered banks with a substantial presence in the banking system; and deliberate measures taken by the provincial legislatures and the Imperial government to suppress significant banking innovations including non-chartered banks. These notes are an attempt to assemble the historical record on one of these developments. We review and consolidate the available evidence concerning non-chartered banks, including evidence on their quantitative importance. The literature on the non-chartered banks of this period is scanty. The most extensive discussion, largely anecdotal, is by Adam Shortt (Shortt, 1986,295-337). By contrast, Breckenridge's exposition is very brief (Breckenridge, 1910, 36), and they are given but passing mention in the two standard modern histories (McIvor, 37-38; Neufeld, 39-40). Although the non-chartered banks had a short existence, they had quantitative importance and the fact that they represented a plausible alternative form of banking organization that has been much touted in recent years suggests that they merit more careful attention (White, 1984; Selgin, 1988). Unfortunately, there is little evidence; they left more shadows than records.
DŁUGOTERMINOWE DECYZJE W ZAKRESIE FINANSÓW PRZEDSIĘBIORSTWA NA PRZYKŁADZIE PRZEDSIĘBIORSTWA Z BRANŻY PRODUKCJI METALOWYCH WYROBÓW GOTOWYCH, Z WYŁĄCZENIEM MASZYN I URZĄDZEŃ
Creators: name: Jarosz, Renata
Publisher: name: figshare
Year: 2013
Subjects: Economics

description: Raport ten zawiera zagadnienia dotyczące podejmowania długoterminowych decyzji finansowych. Korzystanie z nich zostanie przedstawione na przykładzie przedsiębiorstwa X z branży produkcji metalowych wyrobów gotowych, z wyłączeniem maszyn i urządzeń.