cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structure, proteolysis, and evolution of secreted tuberculosis virulence factors
Creators: name: Solomonson, Matthew Morris
Publisher: name: University of British Columbia
Year: 2015

description: Mycobacterium tuberculosis uses the ESX-1 type VII secretion system to export proteins to its cell surface, which permeabilize the host macrophage phagosomal membrane, allowing the bacterium to escape and spread to new cells. The structure of the type VII membrane complex and how it mediates this function is unknown, but it is hypothesized that some of the secreted proteins form an extracellular appendage that facilitates membrane lysis or direct secretion of virulence factors into the host cytoplasm. This thesis investigates the structural relationship between one of these secreted proteins, EspB, and a protease that processes it, MycP1. The x-ray crystallographic structures of both proteins are determined and described. EspB is shown to form a multimer with heptameric stoichiometry, and an EM reconstruction of this multimer is generated and used to create a model of the oligomer using symmetric Rosetta docking. The final model is supported by mass spectrometry-based detection of chemically cross-linked peptides from adjacent subunits. We use mass spectrometry to determine how EspB is proteolytically processed during secretion and discuss the effect of this processing event on the EspB ultrastructure. Finally, the structure of one of the membrane apparatus proteins, EccB1 is determined, revealing structural homology to a phage lysin. The combination of x-ray crystallography, EM, modeling, and mass-spectrometry provides an exciting first glimpse at the structure and function of the type VII secretion system - a critical factor in the TB pathogenesis cycle.
INTRODUCTION OF AUGHMENTED REALITY TECHNOLOGIES TO MUSEUM EXPOSITIONS
Creators: name: Sakenova Zh.Zh.
name: Smagulova, A.S.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: subject: Tourism
subject: FOS: Economics and business
subject: augmented reality
subject: 3D-model
subject: museums
subject: modern civilization
subject: heritage
subject: exhibits.

description: Tourism is becoming an important part of the development of modern society. Museums, as the most significant social institutions involved in the identification, preservation, study and popularization of heritage, are designed to adequately respond to the challenges of the times, become more attractive to tourists and participate in the development of the tourism business. The article is devoted to the issues of integrating augmented reality technologies into the museum space. Augmented reality technology is a relatively new industry for Kazakhstan. The correct application of these technologies allows you to solve several problems at once: convenient information on exhibits, detailed examination of exhibits, access to which is limited, virtual reconstruction of completely or partially lost works of art, etc. The use of such tools will allow organizing productive interaction of the viewer with museum expositions, as well as allowing museums to find a new wave of popularity among city residents and visitors. The direct experience of the development and implementation of augmented reality technologies in the Karaganda forced labor camp (abbreviated Karlag), which is one of the largest camps in the USSR, is examined. In general, the relevance of the topic lies in the fact that developing an application using augmented reality technology to create an information museum makes it possible to actualize the importance of museums in the modern world.
Critical Comparative Analysis and Recommendation in MAC Protocols for Wireless Mesh Networks Using Multi-objective Optimization and Statistical Testing
Creators: name: Singh, Ankita
name: Singh, Sudhakar
name: Prakash, Shiv
Publisher: name: arXiv
Year: 2023
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Wireless Mesh Network (WMN) is surely one of the prominent networks in the modern era which is widely used in numerous evolving applications, viz. broadband home networking (BHN), community and neighbourhood networks (CNN), coordinated network management (CNM), and intelligent transportation systems (ITS), etc. It is a wireless network (WN) with multi-hop formed by many fixed wireless mesh routers (WMR) that are connected wirelessly with a mesh-alike backbone arrangement. In the IEEE 802.11s network, the node selection, scalability, stability, density of the nodes, mobility of the nodes, transmission power, and routing are major issues that WMN suffers. In this paper, a critical review of MAC protocols and their Quality of Service (QoS) parameters for WMN is presented to attain a better understanding of MAC protocols. Furthermore, the critical comparative analysis and recommendation of MAC procedures for WMN using Multi-objective optimization and statistical testing framework are performed. This framework is used for the analysis and recommendation of different protocols available for QoS parameters.
description: 20 pages, 4 figures, Wireless Personal Communication
Polar Fusion Technique Analysis for Evaluating the Performances of Image Fusion of Thermal and Visual Images for Human Face Recognition
Creators: name: Bhowmik, Mrinal Kanti
name: Bhattacharjee, Debotosh
name: Basu, Dipak Kumar
name: Nasipuri, Mita
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper presents a comparative study of two different methods, which are based on fusion and polar transformation of visual and thermal images. Here, investigation is done to handle the challenges of face recognition, which include pose variations, changes in facial expression, partial occlusions, variations in illumination, rotation through different angles, change in scale etc. To overcome these obstacles we have implemented and thoroughly examined two different fusion techniques through rigorous experimentation. In the first method log-polar transformation is applied to the fused images obtained after fusion of visual and thermal images whereas in second method fusion is applied on log-polar transformed individual visual and thermal images. After this step, which is thus obtained in one form or another, Principal Component Analysis (PCA) is applied to reduce dimension of the fused images. Log-polar transformed images are capable of handling complicacies introduced by scaling and rotation. The main objective of employing fusion is to produce a fused image that provides more detailed and reliable information, which is capable to overcome the drawbacks present in the individual visual and thermal face images. Finally, those reduced fused images are classified using a multilayer perceptron neural network. The database used for the experiments conducted here is Object Tracking and Classification Beyond Visible Spectrum (OTCBVS) database benchmark thermal and visual face images. The second method has shown better performance, which is 95.71% (maximum) and on an average 93.81% as correct recognition rate.
description: Proceedings of IEEE Workshop on Computational Intelligence in Biometrics and Identity Management (IEEE CIBIM 2011), Paris, France, April 11 - 15, 2011
Additional file 4 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 4.: Extended Figure 5 The file provides the figure 5 in a plain page to make structures and text more readable.
IRAQI POETS ON “AZERBAIJAN” JOURNAL PAGES
Creators: name: Pashayeva, Aynura
Publisher: name: Colloquium-journal
Year: 2020
Subjects: Iraq
Azerbaijan
Bandaroglu
poetry
magazine
Al-Bayati.

description: It is very important to study Islamic solidarity not only in the context of religious unity, but also in the context of literary and cultural relations. The declaration of 2017 as the Year of Islamic Solidarity raises the question of studying literary and cultural relations with Islamic countries. Iraq is one of the Islamic countries with an ancient and rich culture. If you look at the history of Azerbaijani-Iraqi cultural relations, then Iraq was the only Arab country with long-standing cultural ties with Azerbaijan. This is primarily due to the proximity of Iraq and Azerbaijan. Azerbaijan magazine, one of the active mass media of the Writers' Union of Azerbaijan, played an important role in the development of literary ties between the two Islamic states. Thus, the works of Nizar Abbas, Zahid Mohammad, Abdul-Wahhab al-Bayati, Abdullatif Bandaroglu and other Iraqi authors, who wrote in Arabic since Soviet times, were translated and published in the journal "Azerbaijan" and were first based on these works in the study of Azerbaijan Iraqi literary relations. is an important.
JCEM Supplementary material.pdf
Creators: name: Chou, Chen Kai
name: Kang, Hong-Yo
Publisher: name: figshare
Year: 2023
Subjects: Cancer cell biology
Oncology and carcinogenesis not elsewhere classified

description: Supplementary material of manuscript which entitled of Clinical impact of androgen receptor-suppressing miR-146b expression in papillary thyroid cancer aggressiveness
Material anexo al artículo “Cambios en los patrones de consumo de alcohol y tabaco antes y durante la pandemia de COVID – 19. ENSANUT 2018 y 2020”
Creators: name: Barrera-Núñez, David
name: Rengifo Reyna, Herney A.
name: López-Olmedo, Nancy
name: Barrientos-Gutierrez, Tonatiuh
name: Reynales-Shigematsu, Luz Myriam
Publisher: name: figshare
Year: 2022
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Material anexo al artículo “Cambios en los patrones de consumo de alcohol y tabaco antes y durante la pandemia de COVID – 19. ENSANUT 2018 y 2020”
Additional file 3 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 3.: Extended Figure 4 The file provides the figure 4 in a plain page to make structures and text more readable.
Asymptotic behaviour of tipping points in non-autonomous systems with random and periodic forcing
Creators: name: Zhu, Jielin
Publisher: name: University of British Columbia
Year: 2015

description: We consider the effect on tipping from an additive periodic forcing and an additive white noise in a canonical model with a saddle-node bifurcation and a slowly varying bifurcation parameter. Using a multiple scales analysis, we consider the effect of amplitude and frequency of the periodic forcing relative to the drifting rate of the varying bifurcation parameter. We show that a high frequency oscillation drives an earlier tipping when the bifurcation parameter varies more slowly, with the advance of the tipping point proportional to the square of the ratio of amplitude to frequency. In the low frequency case the position of the tipping point is affected by the frequency, amplitude and phase of the low frequency oscillation. The results are based on an analysis of the local concavity of the trajectory. The tipping point location increases with the amplitude of the periodic forcing, with critical amplitudes where there are jumps in the location. Using a WKB method and a multi-scale analysis, we consider the effect of the amplitude of the noise relative to the drifting rate of the bifurcation parameter. We show that the early tipping is likely to happen if the drifting rate of the bifurcation parameter is smaller than the square of the amplitude of the noise. The WKB approximation shows that the quasi-stationary PDF is related to the potential well of the system. The probability of early tipping, which is related to the PDF near the unstable equilibrium, should be considered locally through a convection-diffusion process. The analysis of the Morris-Lecar model with oscillations shows that the method of multiple scales we used is applicable to the higher dimensional system. For the sea ice model, the method of multiple scales is adapted for the case when the amplitude of the oscillation is larger than its frequency. We applied the WKB method and the multi-scale analysis on the zero-dimensional climate model which has an asymmetric structure of the saddle-node bifurcation. The approximation of the PDF shows that the asymmetry of the shape of the bifurcation diagram plays an important role in the probability of early tipping.
The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates
Creators: name: Sela, Noa
name: Kim, Eddo
name: Ast, Gil
Publisher: name: arXiv
Year: 2010
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Background: Transposable elements (TEs) have played an important role in the diversification and enrichment of mammalian transcriptomes through various mechanisms such as exonization and intronization (the birth of new exons/introns from previously intronic/exonic sequences, respectively), and insertion into first and last exons. However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammalian, non-mammalian vertebrates and invertebrates. Results: We analyzed the influence of TEs on the transcriptomes of five species, three invertebrates and two non-mammalian vertebrates. Compared to previously analyzed mammals, there were lower levels of TE introduction into introns, significantly lower numbers of exonizations originating from TEs and a lower percentage of TE insertion within the first and last exons. Although the transcriptomes of vertebrates exhibit a significant level of exonizations of TEs, only anecdotal cases were found in invertebrates. In vertebrates, as in mammals, the exonized TEs are mostly alternatively spliced, indicating selective pressure maintains the original mRNA product generated from such genes. Conclusions: Exonization of TEs is wide-spread in mammals, less so in non- mammalian vertebrates, and very low in invertebrates. We assume that the exonization process depends on the length of introns. Vertebrates, unlike invertebrates, are characterized by long introns and short internal exons. Our results suggest that there is a direct link between the length of introns and exonization of TEs and that this process became more prevalent following the appearance of mammals.
Kinetics, mechanism, and identification of photodegradation products of phenazine-1-carboxylic acid
Creators: name: Huasong, Peng
name: Qingwen, Huan
name: Bilal, Muhammad
name: Wang, Wei
name: Zhang, Xuehong
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Phenazine-1-carboxylic acid (PCA) is a broad-spectrum antibiotic against many plant pathogens, produced by Pseudomonas and other species. The biosynthesis and regulation of PCA has been well documented, but there is no report about its photochemical properties. Herein, the photodegradation of PCA was carried out in an aqueous solution under the irradiation of visible light to investigate the kinetics, mechanism, and identification of photodegradation products of PCA. Results revealed that photodegradation of PCA accorded well with first-order reaction kinetics. The measured half-life of PCA was 2.2 days at pH 5.0 and increased to 37.6 days at pH 6.8 when exposed to visible light. When oxygen was removed from its solution, the half-life of PCA was doubled. Different units of superoxide dismutase (SOD) enzyme (i.e. 0, 300, and 3000 units) and varying concentrations of sodium azide (i.e. 0 mg, 5 mg, 10 mg, and 20 mg) were used to decipher the mechanism for PCA photodegradation. Hydroxyl PCA and hydroxy phenazine were tentatively identified as the degradation products of PCA photodegradation process by high-performance liquid chromatography (HPLC). The obtained degradation products were further characterized and confirmed by HPLC-mass spectrometry and LC-MS/MS-based analytical approaches. In conclusion, the degradation of PCA was found to be light dependent, which could be accelerated by hydrogen ion and oxidant in the solution. The results suggest that PCA was more stable when stored in a neutral or alkaline environment or in the dark. Therefore, it is important to modify the PCA structure or use a suitable dosage for its broad-spectrum applications.
Culture influences rates of mind wandering
Creators: name: Sude, Daniel Jeffrey
Publisher: name: University of British Columbia
Year: 2015

description: Mind-wandering – the decoupling of the mind from external stimuli such that it is engaged in a greater degree of self-generated mental activity – requires both a) a focus on internal psychological states and b) a cessation of effortful engagement in the external world. Cultures differ on both dimensions. Members of Asian cultures tend to focus less on internal psychological states than do members of European-heritage cultures. Members of Asian cultures tend to believe that effort is intrinsically rewarding and to value cultivation of one’s capacity for effort. We thus hypothesize that Asian-heritage participants will mind-wander less than European-heritage participants, even during a task where performance is not directly incentivized. In this study, we show that European-heritage UBC students do indeed mind-wander more than either Asian-heritage UBC students or Japanese exchange students when they are participating in an easy and repetitive task.
Additional file 5 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 5.: Description of thirty HAA and Caffeine structure used as pipeline input This pdf file describes the SMILES formula and 2D-structure of each of the thirty HAA and the Caffeine studied in the paper.
METHODOLOGICAL APPROACH TO THE USE OF ALPLOGO PROGRAMMING LANGUAGE IN THE TEACHING OF "MATHEMATICIAN TORTOISE" IN VII GRADE
Creators: name: Jabrayilzada, Sevinj
Publisher: name: Colloquium-journal
Year: 2020
Subjects: LOGO language
ALPLogo programme
Software

description: LOGO language helps students in grades 5-7 to develop creative thinking and problem-solving skills. For many years now, many countries around the world have been holding competitions and contests among stu-dents on various projects in the LOGO language. The most important feature of the ALPLogo program is that in this program teams for Turtle can be assembled in Azerbaijani, English , Russian. The system accepts all three languages.
Quantum Reading of a Classical Digital Memory
Creators: name: Pirandola, Stefano
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Emerging Technologies (cs.ET)
subject: Optics (physics.optics)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We consider a basic model of digital memory where each cell is composed of a reflecting medium with two possible reflectivities. By fixing the mean number of photons irradiated over each memory cell, we show that a non-classical source of light can retrieve more information than any classical source. This improvement is shown in the regime of few photons and high reflectivities, where the gain of information can be surprising. As a result, the use of quantum light can have non-trivial applications in the technology of digital memories, such as optical disks and barcodes.
description: PRL selected by the APS editors for a synopsis in "Physics". This document is the published Letter only. See arXiv:0907.3398 for a longer document which includes both the Letter (4 pages) and the Supplemental Material (21 pages)
Characterization of hippocalcin-like protein 1 (HPCAL1), a neuronal calcium sensor protein in the retina
Creators: name: Tam, Aleeza Hoi Ting
Publisher: name: University of British Columbia
Year: 2015

description: Hippocalcin-like protein 1 (HPCAL1) is a neuronal calcium sensor (NCS) protein found in the brain and in the retina. NCS proteins have important roles in signaling pathways including phototransduction; however, the role of HPCAL1 in the retina remains unresolved. The objective of this thesis is to characterize HPCAL1 and identify its potential interacting partners in the retina. The first part of the thesis examines the localization and characteristics of HPCAL1 using a variety of biochemical assays. The presence of HPCAL1 in the retina was confirmed with RT-PCR, Western blotting analysis, and immunofluorescence microscopy. Since NCS proteins respond to intracellular calcium level changes, HPCAL1 was expressed and isolated from both mammalian cells and E. coli to study its calcium binding properties and other characteristics. Results from a gel mobility shift assay and a fluorescence assay clearly indicated that HPCAL1 undergoes conformational changes upon calcium binding. Furthermore, membrane association assays confirmed that retinal HPCAL1 possesses the calcium-myristoyl switch mechanism which responds to the presence or absence of calcium. NCS proteins often interact with other proteins to perform their functions; therefore, the second part of the study involves the use of mass spectrometry in an attempt to identify calcium-dependent interacting partners of HPCAL1. Over 300 potential interacting partners were identified, and selected proteins were subjected to co-immunoprecipitation and Western blotting analysis or co-localization studies using immunofluorescence microscopy in order to confirm their interactions with HPCAL1. TorsinA has been identified as a calcium-dependent interacting partner to HPCAL1; however, further studies will have to be conducted to determine the significance of this interaction and to confirm other potential interacting partners that were identified in the mass spectrometry analysis. The results of this study provide important technical information on the biochemical characterization of HPCAL1 and the properties of HPCAL1 in the retina. Not only has the identification of potential interacting partners of HPCAL1 provided first insights at its possible role or function in the retina, it has also pointed out the potential for identifying interacting partners of other NCS proteins using mass spectrometry.
Additional file 6 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 6.: Metabolites of AαC, PhIP and MeIQx founded in predicted metabolism maps The file provides a table describing for each metabolite experimentally described if they are predicted by SyGMa and if they are known to produce DNA adduct.
Next Level of Data Fusion for Human Face Recognition
Creators: name: Bhowmik, Mrinal Kanti
name: Majumdar, Gautam
name: Bhattacharjee, Debotosh
name: Basu, Dipak Kumar
name: Nasipuri, Mita
Publisher: name: arXiv
Year: 2011
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper demonstrates two different fusion techniques at two different levels of a human face recognition process. The first one is called data fusion at lower level and the second one is the decision fusion towards the end of the recognition process. At first a data fusion is applied on visual and corresponding thermal images to generate fused image. Data fusion is implemented in the wavelet domain after decomposing the images through Daubechies wavelet coefficients (db2). During the data fusion maximum of approximate and other three details coefficients are merged together. After that Principle Component Analysis (PCA) is applied over the fused coefficients and finally two different artificial neural networks namely Multilayer Perceptron(MLP) and Radial Basis Function(RBF) networks have been used separately to classify the images. After that, for decision fusion based decisions from both the classifiers are combined together using Bayesian formulation. For experiments, IRIS thermal/visible Face Database has been used. Experimental results show that the performance of multiple classifier system along with decision fusion works well over the single classifier system.
description: Keywords: Thermal Image, Visual Image, Fused Image, Data Fusion, Wavelet decomposition, Decision Fusion, Classification
THE EFFECTIVENESS OF GOVERNMENT STIMULUS PROGRAMS
Creators: name: Mammadova Gunel
Publisher: name: Colloquium-journal
Year: 2020

description: The financial crisis of 2008, also known as the Great Recession, was the largest financial shock since the Great Depression. The crisis heavily damaged markets and institutions at the core of the financial system. The GDP growth was only 2% and unem-ployment was 7.7% in 2008. The house prices fell almost 2.5% every other month. Many economists were warning even more catastrophic outcomes such as a global recession or even a Great Depression (Stewart, 2008).
Additional file 7 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 7.: Distribution of 3 HAA production probability score The file provides the distribution of production probability scores used in Fig. 6 but in full page format.
Parametrization and multiple time scale problems with non-Gaussian statistics related to climate dynamics
Creators: name: Thompson, William F.
Publisher: name: University of British Columbia
Year: 2015

description: Many problems in climate modelling are characterized by their chaotic nature and multiple time scales. Stochastic parametrization methods can often simplify the analysis of such problems by using appropriate stochastic processes to account for degrees of freedom that are impractical to model explicitly, such that the statistical features of the reduced stochastic model are consistent with more complicated models and/or observational data. However, applying appropriate stochastic parametrizations is generally a non-trivial task. This is especially true when the statistics of the approximated processes exhibit non-Gaussian features, like a non-zero skewness or infinite variance. Such features are common in problems with nonlinear dynamics, anomalous diffusion processes, and multiple time scales. Two common topics in stochastic parameterization are model parameter estimation and the derivation of reduced stochastic models. In this dissertation, we study both of these topics in the context of stochastic differential equation models, which are the preferred formalism for continuous-time modelling problems. The motivation for this analysis is given by problems in atmospheric or climate modelling. In Chapter 2, we estimate parameters of a dynamical model of sea surface vector winds using a method based on the properties of differential operators associated with the probabilistic evolution of the wind model. The parameter fields we obtain allow us to reproduce statistics of the vector wind data and inform us regarding the limitations of both the estimation method and the model itself. In Chapter 3, we derive reduced stochastic models for a class of dynamical models with multiple time scales that are driven by α-stable stochastic forcing. The results of Chapter 3 are applied in Chapter 4, where we derive a similar approximation for processes that are driven by a fast linear process experiencing additive and multiplicative Gaussian white noise forcing. The results of these chapters complement previous results for systems driven by Gaussian white noise and suggest a possible dynamical mechanism for the appearance of α-stable stochastic forcing in some climatic time series.
Preliminary Functional-Structural Modeling on Poplar (Salicaceae)
Creators: name: Liu, Dongxiang
name: Kang, Meng Zhen
name: Letort, Véronique
name: Xing, Meijun
name: Gang, Yang
name: Huang, Xinyuan
name: Cao, Weiqun
Publisher: name: arXiv
Year: 2010
Subjects: subject: Dynamical Systems (math.DS)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Mathematics
subject: FOS: Biological sciences

description: Poplar is one of the best fast-growing trees in the world, widely used for windbreak and wood product. Although architecture of poplar has direct impact on its applications, it has not been descried in previous poplar models, probably because of the difficulties raised by measurement, data processing and parameterization. In this paper, the functional-structural model GreenLab is calibrated by using poplar data of 3, 4, 5, 6 years old. The data was acquired by simplifying measurement. The architecture was also simplified by classifying the branches into several types (physiological age) using clustering analysis, which decrease the number of parameters. By multi-fitting the sampled data of each tree, the model parameters were identified and the plant architectures at different tree ages were simulated.
The lived experience of South Asian women with gestational diabetes mellitus
Creators: name: Deol, Harleen
Publisher: name: University of British Columbia
Year: 2015

description: Factors that influence differentially managed gestational diabetes mellitus (GDM) and variances in adherence to GDM guidelines among the South Asian women were investigated using a qualitative design. There is a lack of descriptive literature related to this topic and subsequently the need for a better understanding to provide optimal care for this population of women. A phenomenological approach provided the research approach to generate descriptive knowledge of women’s lived experience of managing and adhering to GDM guidelines. Thus, the purpose of this research was to understand the lived experiences of South Asian women managing GDM. The research question guiding the study was: What is the lived experience of managing GDM for women of South Asian descent? The results from this research study will assist health care providers to understand the experiences of South Asian women and how their experience affects their ability to effectively manage GDM. Findings from this study will aid in developing and implementing strategies that can raise awareness and contribute to successful management of GDM among this population. The overall aim is to contribute such knowledge to assist with the development of population-specific intervention strategies to enable these women to successfully manage GDM.
Additional file 8 of Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA
Creators: name: Conan, Mael
name: Théret, Nathalie
name: Langouet, Sophie
name: Siegel, Anne
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 8.: Description of six HAA maps of metabolism The file provides a detailed description of metabolites for the six HAA filtered maps of metabolism built in the paper. For each metabolite of each map, the file provides the identifier of the metabolite, its SMILES formula, its production probability score, its reactivity to DNA and the score of XenoSite Reactivity.
THE EFFECT OF CADMIUM ON THE LEVEL OF VITAMINS A AND E IN THE BLOOD OF YOUNG CATTLE
Creators: name: Lavryshyn, Y.
name: Gutyj, B.
name: Leskiv Ch.
name: Kalyn, B.
name: Holub О.
name: Romanovych, M.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: toxicology
bulls
Cadmium
vitamins A and E
antioxidant system.

description: The study aimed to examine the effect of cadmium load on the level of vitamins A and E in young cattle's blood. The research was conducted based on a farm in the village of Ivanivtsi, Zhydachiv district, Lviv region, on ten six-month-old bulls, Ukrainian black-and-white dairy breed, which was formed into two groups of five animals each: control (C) and experimental (E). The bulls of the control group were on a regular diet. The (E) group animals were fed cadmium chloride at a dose of 0.04 mg/kg body weight. The test lasted for 30 days. For research, the rules obligatory for performing zootechnical experiments on selecting and keeping analogous animals in groups, harvesting technology, use, and accounting of consumed feed were followed. The animals' diet was balanced in terms of nutrients and minerals, which provided their need for essential nutrients. The investigations were carried out under the principles of humanity set out in the European Community Directive. The experiment results indicate that Cadmium significantly affects liver cells' metabolism, thus stimulating the processes of lipid peroxidation and inhibiting the activity of the non-enzymatic part of the antioxidant system, the level of vitamins A and E in the blood of young cattle. The lowest level of vitamins A and E was in the blood of the (E) group of bulls on the 20th day of the experiment, respectively, fluctuated between 0.62 ± 0.035 and 2.9 ± 0.10 μmol/l. Only on the 5th day of the investigation there was a slight increase in the content of vita-mins, which may be due to the protective effect of bulls' body on the intake of cadmium chloride in a toxic dose. The studies made it possible to more deeply reveal the pathogenesis of Cadmium's poisonous effects on young cattle's body and use these data to develop an antidote for cadmium intoxication.
THE EFFECT OF FEED ADDITIVE “BUTASELMEVIT-PLUS” ON RATS' BLOOD'S MORPHOLOGICAL PARAMETERS UNDER CARBON TETRACHLORIDE INTOXICATION CONDITIONS
Creators: name: Martyshuk, T.V.
name: Gutyj, B.V.
name: Leskiv Ch.Ya.
name: Slobodiuk, N.M.
name: Rudenko, O.P.
name: Khalak, V.I.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: oxidative stress
rats
butaselmevit-plus
blood
milk thistle.

description: The research aimed to study the effect of feed additive "Butaselmevit-plus" on rats' blood's morphological parameters under conditions of carbon tetrachloride intoxication. The study was performed on white sexually mature young male Wistar rats weighing 180-200 g, which were kept on the standard diet of the institute vivarium of the State Research Control Institute of Veterinary Drugs and Feed Additives. The animals were divided into three groups of 20 animals each: Group 1 (C) intact animals; 2nd group (E1) rats affected by carbon tetrachloride; Group 3 (E2) rats affected by carbon tetrachloride and used feed additive "Butaselmevit-plus." Experimental intoxication in animals was performed by two (after 48 h) intravesical administration of carbon tetrachloride at a dose of 0.1 ml per 100 g of rat body weight in the form of a 50% oil solution. Group E2 in trial toxicosis for 30 days was supplied a feed additive "Butaselmevit-plus" at a dose of 0.1 g per 100 g of body weight with food. It was found that under conditions of intoxication with carbon tetrachloride in rats, the bone marrow's hematopoietic function is impaired, which is manifested by a decrease in the number of erythrocytes by 26.5%, hemoglobin content by 8.7%. During applying the feed additive "Butaselmevit-plus" in mice, under forms of oxidative stress during the research, the blood normalizes the activity of hematological parameters, namely on the 25th and 30th day within physiological values were indicators of erythrocytes, hemoglobin, leukocytes, and red blood cell indices compared to controls, indicating the restoration of hematopoietic function of the bone marrow.
АБСТРАКТНЫЕ И ЗЛОВРЕДНЫЕ РЕКОМЕНДАЦИИ ВНЕДРЕНИЯ ПСЕВДОРЕЗУЛЬТАТОВ ИССЛЕДОВАНИЯ ОБ АЭРОПОРТАХ МВЛ
Creators: name: Леонтьев Рудольф Георгиевич
Publisher: name: Colloquium-journal
Year: 2020
Subjects: менеджмент аэропортами
местные воздушные линии (МВЛ)
государственная научная аттестация
диссертация
отзыв ведущей организации
рекомендации по использованию результатов и выводов дис-сертации.

description: В статье рассмотрена представленная в отзыве ведущей организации нелепая попытка его проду-центов сформулировать абстрактные рекомендации по использованию результатов и выводов диссер-тации о менеджменте аэропортами местных воздушных линий. Доказано, что эта попытка сотрудни-ков МИИТ вызвана их халатным незнанием текста диссертации, а ее (попытки) результатом стала фальсифицированное (то есть на самом деле несуществующее в действительности) содержимое этой научно-квалификационной работы.
Predictors of outcomes in emergency general surgery patients : a scoping review
Creators: name: Al Hinai, Alreem
Publisher: name: University of British Columbia
Year: 2015

description: Background: Emergency General Surgery (EGS) patients have unique physiologic characteristics and are at a high risk of complications compared to elective general surgery patients. We aimed to perform a scoping review of the literature that examines predictors of outcomes in EGS patients. Methodology: A scoping review of published literature from 2004 to May 2015 was conducted in Medline, EMBASE, Cochrane library and PubMed. Keywords were chosen based on the three most common diagnoses in EGS; acute appendicitis, cholecystitis and small bowel obstruction, in addition to emergency general surgery, acute care surgery, outcomes & post-operative complications. Articles meeting inclusion criteria were summarized. Quantitative data regarding study characteristics were analyzed and expressed as descriptive statistics. Qualitative data from included studies were grouped intro predictors based on a framework derived from a grounded theory approach to content analysis. Primary outcomes of interest were post-operative morbidity and mortality. A predictor was included if it was significantly correlated with an outcome based on a minimum of bivariate analysis. Results: A total of 715 articles were identified during the primary search, of those 62 were found to be relevant to the search criteria. Almost all of the studies were retrospective. The median number of patients in these studies was 1000 (IQR 266,20896) with a mean of median/mean age reported of 53.2 years. Average length of follow up was 4.6 years. There were 54 predictors of outcome identified and these were grouped into patient related, process related and structure/system related predictors. The most frequently reported predictor of any adverse outcome was absence of an EGS system, followed by an ASA score of 3 or more. The most frequently reported predictor of post-operative morbidity was absence of EGS system. The most frequently reported predictor of mortality was age ≥ 65, emergency status and ASA ≥ 3. Conclusion: EGS patients are at a higher risk of post-operative adverse outcome as compared to elective surgical patients. System implementation significantly improves outcomes in this patient population. Identifying what predicts adverse outcomes can help in future risk assessment scores, planning future prospective trials and improving performance in emergency general surgery systems.
Pre-malignant transformation of normal mammary epithelial cells compromises tensional homeostasis at cell-cell junctions
Creators: name: Poon, Tak Kwong
Publisher: name: University of British Columbia
Year: 2015

description: Cell-cell junctions regulate the form and function of epithelial tissues, in part, by mechanically coupling adjacent cells together. Unlike normal cells, pre-malignant cells are capable of mechanically uncoupling these junctions in response to motogenic factors such that the cells become invasive and, ultimately malignant. Therefore, I asked whether the mechanical responses of cell-cell junctions to increases in intracellular tension are altered in pre-malignant mammary epithelial cells in the absence of such motogenic factors. In an effort to answer this question I altered the intracellular tension on the cell-cell junctions of normal (EpH4) and pre-malignant oncogenic ras-transformed (EpRas) mammary epithelial cells either chronically, by altering the density of cells attached to a rigid substratum, or acutely, by physically extending (i.e. ‘stretching’) confluent monolayers of cells attached to a compliant silicone rubber substrate. When intracellular tension was chronically increased, the tension-sensitive protein zyxin relocalized to cell-cell junctions in normal, but not pre-malignant cells. The zyxin relocalization in normal cells was associated with a junctional increase in the phosphorylated form of myosin light chain 2 (MLC2) suggesting that it may involve actomyosin contractility. The same differential in zyxin relocalization and phosphorylated MLC2 accumulation occurred when the intracellular tension was acutely increased in the two cell types. This differential was blocked by Rho-ROCK inhibition which indicates that it may be dependent on actomyosin contractility. In addition, apical actin structure reorganization occurred when intracellular tension was acutely increased in the normal cells that did not occur in the pre-malignant cells. Taken together, these observations led me to conclude that the ability of cell-cell junctions to respond in a mechanosensory-appropriate manner to changes in intracellular tension is compromised in ras-transformed pre-malignant mammary epithelial cells. Acute pharmacologic inhibition of oncogenic Ras-mediated increases in MAPK and/or PI3K signalling did not correct this compromised response. Therefore, this compromised mechanosensitivity, which may functionally contribute to the ability of pre-malignant cells to become invasive in response to motogenic factors, may be initiated by long term epigenetic changes that occur under conditions of stable oncogenic transformation.
АГРОМАРКЕТИНГ В СИСТЕМІ УПРАВЛІННЯ ПІДПРИЄМСТВОМ: ТЕОРЕТИЧНИЙ АСПЕКТ
Creators: name: Красняк О.П.
name: Амонс С.Е.
Publisher: name: Colloquium-journal
Year: 2020
Subjects: сільське господарство
аграрний ринок
підприємство
агромаркетинг
управління
служба маркетингу
економіка.

description: У статті досліджено теоретичні основи ролі агромаркетингу в системі управління вітчизняних аг-рарних підприємств. Результати вивчення викладеної теми дозволяють систематизувати агромаркетингову діяльність підприємств, формують розуміння особливості сучасного агромаркетингу. Доведено, що для агромаркетингу необхідні більш конкретні напрямки маркетингових досліджень, спрямовані на взаємозалежний вплив функцій маркетингу на споживача: формування і стимулювання попиту; розширення обсягів продажів, ринкової частки і прибутку, а також на досягнення оптимальних управлінських рішень.