cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Factor Structure of the National Alzheimerʼs Coordinating Centers Uniform Dataset Neuropsychological Battery: An Evaluation of Invariance Between and Within Groups Over Time
Creators: name: Pieper, Carl
name: Warren, Lauren H.
name: Zimmer, Catherine
name: Jones, Richard N.
name: Welsh-Bohmer, Kathleen A.
name: Browndyke, Jeffrey N.
name: Plassman, Brenda L.
name: Hayden, Kathleen M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The neuropsychological battery from the National Alzheimer’s Disease Coordinating Center (NACC) is designed to provide a sensitive assessment of mild cognitive disorders for multicenter investigations. Comprised of eight common neuropsychological tests (12 measures), the battery assesses cognitive domains affected early in the course of Alzheimer’s disease (AD). We examined the factor structure of the battery across levels of cognition (normal, mild cognitive impairment (MCI), dementia) based on Clinical Dementia Rating (CDR) scores to determine cognitive domains tapped by the battery. Using data pooled from 29 NIA funded Alzheimer’s Disease Centers, exploratory factor analysis was used to derive a general model using half of the sample; four factors representing memory, attention, executive function, and language were identified. Confirmatory factor analysis (CFA) was used on the second half of the sample to evaluate invariance between groups and within groups over one year. Factorial invariance testing included systematic addition of constraints and comparisons of nested models. The general CFA model had a good fit. As constraints were added, model fit deteriorated slightly. Comparisons within groups demonstrated stability over one year. In a range of cognition from normal to dementia, factor structures and factor loadings will vary little. Further work is needed to determine if domains become more or less distinct in severely cognitively compromised individuals.
Detecting and Explaining Conflicts in Attributed Feature Models
Creators: name: Lesta, Uwe
name: Schaefer, Ina
name: Winkelmann, Tim
Publisher: name: arXiv
Year: 2015
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences
subject: D.2.2; D.2.13

description: Product configuration systems are often based on a variability model. The development of a variability model is a time consuming and error-prone process. Considering the ongoing development of products, the variability model has to be adapted frequently. These changes often lead to mistakes, such that some products cannot be derived from the model anymore, that undesired products are derivable or that there are contradictions in the variability model. In this paper, we propose an approach to discover and to explain contradictions in attributed feature models efficiently in order to assist the developer with the correction of mistakes. We use extended feature models with attributes and arithmetic constraints, translate them into a constraint satisfaction problem and explore those for contradictions. When a contradiction is found, the constraints are searched for a set of contradicting relations by the QuickXplain algorithm.
description: In Proceedings FMSPLE 2015, arXiv:1504.03014
title: Multi-parameters derived from a dual-layer spectral CT for evaluation of activity in ileocolonic Crohn’s disease: initial experience
Creators: name: Jiang, Yan
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Gastrointestinal tract
subject: CT-Quantitative
subject: Endoscopy
subject: Acute

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Evaluation of disease extension and activity is crucial in patients with Crohn’s disease (CD) to determine the therapeutic strategy, and has important prognostic implications. This evaluation usually relies on endoscopy. However, endoscopy cannot...
PRIMA DELLA TEMPESTA. IL PENSIERO ANARCHICO ATTRAVERSO LE PAGINE DI 'FREEDOM' (1886-1914)
Creators: name: VARENGO, SELVA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Questa tesi di dottorato ha come obiettivo quello di descrivere attraverso gli articoli del mensile ?Freedom?, uno dei pi� longevi periodici dell'anarchismo contemporaneo, i differenti dibattiti politici, sociali ed economici che animano il movimento anarchico, inglese e internazionale, a cavallo tra ottocento e novecento. In particolare la presente ricerca intende incentrarsi sugli anni tra il 1886, data della pubblicazione del primo numero di ?Freedom?, e il 1914, anno in cui l'anarchico russo P�tr Kropotkin ? uno dei principali fondatori del mensile insieme a Charlotte Wilson ? rende pubblica la sua posizione sulla guerra proprio dalle colonne del giornale londinese, suscitando aspre polemiche e un acceso dibattito all'interno del movimento anarchico sulla posizione da assumere di fronte al conflitto che porteranno l'anarchico russo, dopo ventotto anni di collaborazione, ad allontanarsi definitivamente dalla redazione del periodico. Negli anni tra il 1886 e il 1914, oltre a Kropotkin, numerosi sono i prestigiosi collaboratori di ?Freedom?, tra cui vi sono importanti figure del movimento anarchico e socialista sia inglese che internazionale come la comunarda Louise Michel (1830-1905), il fondatore della Social Democratic Federation Henry Mayers Hyndman (1842-1921), il precursore del movimento di liberazione omosessuale Edward Carpenter (1844-1929), il principale esponente dell'antimilitarismo anarchico olandese Ferdinand Domela Nieuwenhuis (1846-1919), il noto anarchico italiano Errico Malatesta (1853-1932), l'avvocato anarchico e teorico socialista Francesco Saverio Merlino (1853-1930), il redattore della rivista ?Les Temps Nouveaux? Jean Grave (1854-1939), lo scrittore e drammaturgo irlandese George Bernard Shaw (1856-1950), il convinto sostenitore delle Trade Unions Tom Mann (1856-1941), il novellista e poeta omosessuale John Henry Mackay (1864-1933), lo storico dell'anarchismo tedesco Max Nettlau (1865-1944), l'anarchica russa femminista ante-litteram Emma Goldman (1869-1940), il sostenitore di un socialismo anti-autoritario e non violento Gustav Landauer (1870-1919), l'anarco-sindacalista Rudolf Rocker (1873-1958), il georgiano Warlaam Tcherkesoff (1846-1925) e la sua compagna Freda, George Barrett (1888-1917), Vera Figner (1852-1942), e Alexander Berkman (1870-1936).
title: Thinking the Prison Affectively: A Critical Discourse Analysis of Official Prison Reports from Three English Prisons
Creators: name: Rungius, Madeleine
Publisher: name: University of Liverpool Repository
Year: 2022

description: This thesis explores the theoretical and methodological possibilities for understanding the prison as an affective institution. Central to this affective exploration of the prison is to challenge the idea of the rational institution that assumes rationality to be non-affective. On this basis, the prison is often officially narrated as a pacifying and benign institution of state punishment and, as such, is reflected in the official reports of inspection into the contemporary prison in England and Wales. In contrast, this thesis seeks to re-read these officially sanctioned prison narratives using an affective framework, and feminist and imaginative epistemologies. Drawing on Foucauldian Critical Discourse Analysis, prison reports of three English prisons, HMP Birmingham, HMP Liverpool and HMP Pentonville, over a 40-year period (1982-2019) are investigated. This thesis presents a reading of these reports as textual and visual artefacts of official state discourse. The Critical Discourse Analysis of them enables a tracing of affect in a threefold analysis. First, the affective exploration of the prison proceeds from the discursive basis of affect in the textual body of prison reports. Second, the thesis interrogates the imagined prison that transpires through the researcher’s imagination and their creative engagement with prison reports. Third, the discursive analysis engages in a critical visual reading of official state photographs of the three prisons. The analysis aims to establish a critical counter reading of prisons in England and Wales through an affective lens. Theoretically, this thesis is situated in Durkheimian and cultural affect studies which form the basis for the conceptual framework, or what I call the affective moral fact. Establishing this concept seeks to offer an explanatory framework that renders affect more visible in the life of state institutions like the prison. Integral to this tracing of affect is the epistemological foundation in standpoint feminist scholarship that embraces a critical sociological imagination, with the aim of including creative and imaginative ways, for affectively researching the prison and emphasising the situatedness of knowledge. The thesis works towards the conclusion that the prison can be researched and theorised affectively through the critical deconstruction of official prison narratives. Related to the affective moral fact, the rational prison can be seen as promoting a form of state power that is affect-saturated and driven at all times; as a sociocultural representation of dominating affect and values specific to time and place. A central outcome of this thesis is a stress on the importance of research that embraces imagination and emphasises the significance of affect for more nuanced understandings of the rational power and violence of the prison institution.
Scattering versus Forbidden Decay in Dark Matter Freeze-in
Creators: name: Li, Shao-Ping
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is generically believed that the two-body scattering is suppressed by higher-order weak couplings with respect to the two-body decay. We show that this does not always hold when a heavy particle is produced by forbidden decay in a thermal plasma, where the scattering shares the same order of couplings with the decay. We find that there is a simple and close relation between the forbidden decay and the same-order scattering. To illustrate this point, we consider freeze-in production of heavy dark matter via a light scalar mediator. We point out that, when the Boltzmann (quantum) statistics is used, the forbidden decay can contribute to the dark matter relic density at 5$\%$-24$\%$ (10$\%$-$39\%$) with a weak thermal coupling, while the contribution from the scattering channel can be several orders of magnitude larger than from the forbidden decay if the thermal coupling is much smaller. Such a relative effect between the scattering and the forbidden decay could also exist in other plasma-induced processes, such as the purely thermal generation of the right-handed neutrino dark matter, or of the lepton asymmetry in leptogenesis.
description: 8 pages, 3 figures, version accepted for publication in PRD
(100902) Eliza Brock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The increasing efficacy of the heel cord subcutaneous rupture diagnosis before and after reconstruction with ultrasound compression elastography using
Creators: name: Olga, Makarova
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal soft tissue
subject: Trauma
subject: Ultrasound physics
subject: Ultrasound
subject: Surgery

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Actuality. The heel cord (Achilles) is the most powerful and tight of human body tendon.According to literary data, the Achilles tendon rupture frequency is 35% from any and all tendon ruptures [Roox, 1994]. The damage more frequently observed...
Phenotypic regional fMRI activation patterns during memory encoding in MCI and AD
Creators: name: Petrella, Jeffrey
name: Tucker, Karen A.
name: Browndyke, Jeffrey N.
name: Burke, James R.
name: Welsh-Bohmer, Kathleen A.
name: Chiba-Falek, Ornit
name: Hayden, Kathleen
name: Giovanello, Kelly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Reliable blood-oxygen-level-dependent (BOLD) fMRI phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggregate examination of the functional neuroimaging research literature.
SLEEPING BEAUTY FINDS PARTNERS OF ONCOGENIC MYC - A TRANSPOSON-BASED INSERTIONAL MUTAGENESIS SCREEN IN THE EMU-MYC MOUSE
Creators: name: BINDER, HEIDE-MARIE
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Myc triggers a transcriptional program inducing hyper-replication and proliferation but also tumor suppressive mechanisms like apoptosis. Therefore, Myc dependent tumors display high selective pressure to accumulate secondary mutations blocking these tumor-suppressive pathways. In the E�-myc mouse model, Myc is constitutively expressed in the B-cell linage under the control of the immunoglobulin heavy chain enhancer. The most prominent failsafe program known to be disrupted in E�-myc lymphomas is the p53-ARF pathway. In order to find novel cooperating partners of Myc leading to transformation we applied a conditional Sleeping Beauty transposon-based mutagenesis screen in vivo. By adoptive transplantation of E�-myc hematopoietic progenitors we generated 312 experimental animals, prone for lymphoma onset. Data show a strong genetic cooperation between the E�-myc transgene and SB transposon mobilization with accelerated tumor onset. Arising lymphomas were of the pre/pro- and immature B-cell stage and infiltration included extra-lymphatic tissue like the liver. The genomic sequences immediately adjacent to integrated transposons of 184 lymphomas were enriched by ligation-mediated PCR and were sequenced with a multiplexed approach. Based on published (Brett et al., 2011) and new bioinformatic methods, we identify 338 common integration sites (CIS) of which 188 were found mutated in human B-cell lymphoma. Pathway and GO term analysis reveal modulation of the Ras-MAP-kinase signaling pathway. Next to well-known modulators of Myc-induced lymphomagenesis including Bcl-XL, p53, ARF and Mdm2, we find CIS that were not yet reported in E�-myc lymphoma like Map3K5.
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
Creators: name: Galis, Zorina S.
name: Nedergaard, Maiken
name: Zlokovic, Berislav
name: Bain, Lisa J.
name: Koroshetz, Walter
name: Zipfel, Gregory J.
name: Snyder, Heather M.
name: Corriveau, Roderick A.
name: Knopman, David
name: Faber, James E.
name: Craft, Suzanne
name: Bosetti, Francesca
name: Carrillo, Maria C.
name: Wilcock, Donna M.
name: Greenberg, Steven M.
name: Lamb, Bruce T.
name: Montine, Thomas J.
name: Schaffer, Chris B.
name: Wellington, Cheryl
name: Schneider, Julie A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: AbstractScientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.
title: Estimate of liver functional reserve and tumour grade using T1 mapping on Gd-EOB-DTPA-enhanced MRI in HCC patients
Creators: name: Chen, Chenyang
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Liver
subject: Oncology
subject: MR
subject: Computer Applications-Detection, diagnosis
subject: Contrast agent-intravenous
subject: Cancer
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Liver functional reserve estimation plays an essential role in making therapeutic decision and predicting the prognosis of patients with hepatocellular carcinoma (HCC). Gd-EOB-DTPA is a hepatocyte-specific contrast agent for MRI which is selectively...
(100903) Robert Podmore Clark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Simple Algorithm to Predict Incident Kidney Disease
Creators: name: Shoham, David A.
name: Bomback, Andrew S.
name: Klemmer, Philip J.
name: Vupputuri, Suma
name: August, Phyllis A.
name: Kern, Lisa M.
name: Kshirsagar, Abhijit V.
name: Mazumdar, Madhu
name: Bang, Heejung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Despite the growing burden of chronic kidney disease (CKD), there are no algorithms (to our knowledge) to quantify the effect of concurrent risk factors on the development of incident disease.
title: Evaluation of metastasis in patients with thymoma: Multimodal imaging with histologic correlation
Creators: name: Rajaram, Akash
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Mediastinum
subject: Oncology
subject: CT
subject: MR
subject: PET-CT
subject: Radiation therapy / Oncology
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Thymomas accounts for ~40% of all mediastinal tumors [1-3]. They have been associated with different paraneoplastic syndromes such as myasthenia gravis, polymyositis, lupus erythematosis, rheumatoid arthritis, and pure red cell aplasia. Thymomas are...
Neighborhood Income, Health Insurance, and Prehospital Delay for Myocardial Infarction: The Atherosclerosis Risk in Communities Study
Creators: name: Foraker, Randi E.
name: Goff Jr., David C.
name: Wood, Joy L.
name: Rosamond, Wayne D.
name: McGinn, Aileen P.
name: Whitsel, Eric A.
name: Suchindran, Chirayath M.
name: Rose, Kathryn M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Outcomes following an acute myocardial infarction (AMI) are generally more favorable if pre-hospital delay time is minimized.
Multiatom Quantum Coherences in Micromasers as Fuel for Thermal and Nonthermal Machines
Creators: name: Dağ, Ceren B.
name: Niedenzu, Wolfgang
name: Müstecaplıoğlu, Özgür E.
name: Kurizki, Gershon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper we address the question: To what extent is the quantum state preparation of multiatom clusters (before they are injected into the microwave cavity) instrumental for determining not only the kind of machine we may operate but also the quantitative bounds of its performance? Figuratively speaking, if the multiatom cluster is the "crude oil", the question is: Which preparation of the cluster is the refining process that can deliver a "gasoline" with a "specific octane"? We classify coherences or quantum correlations among the atoms according to their ability to serve as (i) fuel for nonthermal machines corresponding to atomic states whose coherences displace or squeeze the cavity field, as well as cause its heating; and (ii) fuel which is purely "combustible", i.e., corresponds to atomic states that only allow for heat and entropy exchange with the field and can energize a proper heat engine. We identify highly promising multiatom states for each kind of fuel and propose viable experimental schemes for their implementation.
description: 13 pages, 8 figures
title: Prevalence of a neurovascular compression of the rostral ventrolateral medulla oblongata in a population-based MR study
Creators: name: Grothe, Sascha
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: CNS
subject: Vascular
subject: MR
subject: MR-Angiography
subject: Diagnostic procedure
subject: Statistics
subject: Epidemiology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Autonomous vasomotor centers of the rostral ventrolateral medulla (RVLM) regulate sympathetic tone and blood pressure. A stimulation of the RVLM via baroreceptor afferents leads to an increase in blood pressure. In contrast, an inhibition of these...
The Coping Strategies Assessment Tool (CSAT).pdf
Creators: name: Douglas, Tanisha
name: Wilkinson, Laura
name: Rowe, Angela C
name: Thirkettle, Martin
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 520304
subject: Health psychology
classificationCode: 520302
subject: Clinical psychology
classificationCode: 520303
subject: Counselling psychology

description: The Coping Strategies Assessment Tool (C-SAT) is a re-development of the novel Distance Affect Regulation Mapping Tool (DARM; Wilkinson & Rowe, 2016). The tool is used to quantify the structure of one’s profile of affect regulation strategies, by identifying the content and size of one’s profile as well as the interacting relationships between the different affect regulation strategies.The development of the CSAT was co-produced through the involvement of lay people, clinical groups, healthcare professionals, and academics and researchers, who recommended improvements to the language, appearance, usability, and accessibility of the tool. The CSAT was subsequently assessed and found to be both a reliable and valid measure.
The Rising Prevalence of Chronic Low Back Pain
Creators: name: Kalsbeek, William D.
name: Wallace, Andrea S.
name: Darter, Jane D.
name: Holmes, George M.
name: Jackman, Anne M.
name: Carey, Timothy S.
name: Castel, Liana D.
name: Freburger, Janet K.
name: Agans, Robert P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: National or state-level estimates on trends in the prevalence of chronic low back pain (LBP) are lacking. The objective of this study was to determine whether the prevalence of chronic LBP, and the demographic, health-related, and care-seeking characteristics of individuals with the condition have changed over the past 14 years.
Monodromy free linear equations and many-body systems
Creators: name: Krichever, I.
name: Zabrodin, A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We further develop the approach to many-body systems based on finding conditions of existence of meromorphic solutions to certain linear partial differential and difference equations which serve as auxiliary linear problems for nonlinear integrable equations such as KP, BKP, CKP and different versions of the Toda lattice. These conditions imply equations of the time evolution for poles of singular solutions to the nonlinear equations which are equations of motion for integrable many-body systems of Calogero-Moser and Ruijsenaars-Schneider type. A new many-body system is introduced, which governs dynamics of poles of elliptic solutions to the Toda lattice of type B.
description: 32 pages, no figures
Effects of the DASH Diet Alone and in Combination With Exercise and Weight Loss on Blood Pressure and Cardiovascular Biomarkers in Men and Women With High Blood Pressure: The ENCORE Study
Creators: name: Johnson, Julie
name: Caccia, Carla
name: Babyak, Michael A.
name: Hinderliter, Alan
name: Blumenthal, James A.
name: Watkins, Lana L.
name: Craighead, Linda
name: Lin, Pao Hwa
name: Waugh, Robert
name: Sherwood, Andrew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiovascular biomarkers of risk.
Universal noise and Efimov physics
Creators: name: Nicholson, Amy N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Probability distributions for correlation functions of particles interacting via random-valued fields are discussed as a novel tool for determining the spectrum of a theory. In particular, this method is used to determine the energies of universal N-body clusters tied to Efimov trimers, for even N, by investigating the distribution of a correlation function of two particles at unitarity. Using numerical evidence that this distribution is log-normal, an analytical prediction for the N-dependence of the N-body binding energies is made.
description: 6 pages, 3 figures. Invited contribution to the 21st International Conference on Few-Body Problems in Physics (FB21)
NON-INTEGRIN CELL ADHESION TRIGGERS LIGAND-INDEPENDENT INTEGRIN SIGNALING
Creators: name: SARRA FERRARIS, GIANNI MARIA
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: Integrins are the major family of cell surface adhesion receptors responsible for the regulation of the physical contact and biochemical communication between the cell and the surrounding extracellular matrix (ECM). Binding of the extracellular domains of integrins to components in the ECM triggers a series of molecular events commonly referred to as ?outside-in? signaling, leading to context-dependent changes in cell morphology, migration and proliferation. In this prevailing paradigm of cell adhesion induced signaling the primary functions of the integrin is to provide the physical transmembrane bridge connecting the intracellular signaling machinery and cytoskeleton to the extracellular environment. We now present evidence that most, if not all, cell adhesion receptors trigger integrin-dependent outside-in signaling independently of direct contacts between the integrins and their ligands in the ECM. The urokinase-type plasminogen activator receptor (uPAR/CD87) is a non-integrin vitronectin (VN) cell adhesion receptor linked to the outer membrane leaflet by a GPI-anchor. Through an extensive structure-function analysis of uPAR, VN, ?1 and ?3 we document that cell adhesion induced by the uPAR/VN-interaction triggers integrin-mediated, but ligand independent, cell spreading and signaling. This signaling is fully active on VN lacking functional integrin binding sites and by integrin mutants deficient in ligand binding, but is crucially dependent on an ?active? conformation of the integrin as well as its binding to intracellular adaptor proteins including talin and kindlin. This novel paradigm of ligand-independent integrin signaling is not restricted to uPAR as it poses no identifiable constraints to the adhesion receptor with respect to ternary-structure, ligand type or means of membrane anchorage. In full accordance with a general validity of this paradigm, we show that cell adhesion physically mediated by a signaling-incompetent ?3 integrin is effectively translated into cell spreading and signaling by the ?1 integrin. Our results show that integrins are active in transducing adhesion-induced signaling in the absence of their cognate ligands, suggesting that the bi-directional signaling capability of these receptors may have evolved primarily to allow for tightly regulated inside-out signaling.
(100904) Mary Webb
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SCATTERING AMPLITUDES IN SUPERCONFORMAL GAUGE THEORIES
Creators: name: LEONI, MARTA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Superconformal field theories have been widely explored over the last years, especially because of their large amount of symmetry which allows to derive exact results. The most prominent example within this class is the four-dimensional maximally supersymmetric N = 4 Super Yang-Mills theory, which played a pivotal role in the proposal of the AdS/CFT correspondence, a conjectured weak/strong duality relating superconformal gauge theories to string theories on curved backgrounds. Soon after the formulation of the correspondence the presence of integrable structures was discovered both in planar N = 4 SYM and in its string counterpart, and since then integrability in superconformal theories became one of the main research topics in theoretical physics. Interestingly, integrability in N = 4 was later shown to be intimately related to the presence of the so called dual conformal symmetry, a hidden symmetry of the planar amplitudes that puts even stronger constraints on their structure. This suggests that some crucial aspects of a theory can be investigated through the computation of its scattering amplitudes, which can thereby provide a powerful tool also for the study of less supersymmetric superconformal field theories. In particular it is essential to understand whether some of the beautiful properties of N = 4 survives when supersymmetry is not maximal. In this thesis we present computations of massless scattering amplitudes in two different not maximally supersymmetric conformal theories: N = 2 superconformal QCD in four dimensions and N = 6 Chern-Simons matter theory (ABJM) in three dimensions. In N = 2 SCQCD we compute all possible four-point amplitudes at one loop and the two-loop amplitude with fundamental fields as external legs. In ABJM we extend the two-loop computation of four-point scattering amplitudes and of the Sudakov form factor beyond the planar limit. We also discuss our results in relation to the corresponding ones in N = 4 SYM, paying particular attention to the possible presence of dual conformal invariance and to maximum transcendentality.
Soliton nanoantennas in two-dimensional arrays of quantum dots
Creators: name: Gligorić, G.
name: Maluckov, A.
name: Hadžievski, Lj.
name: Slepyan, G. Ya.
name: Malomed, B. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We consider two-dimensional (2D) arrays of self-organized semiconductor quantum dots (QDs) strongly interacting with electromagnetic field in the regime of Rabi oscillations. The QD array built of two-level states is modelled by two coupled systems of discrete nonlinear Schrödinger equations. Localized modes in the form of single-peaked fundamental and vortical stationary Rabi solitons and self-trapped breathers have been found. The results for the stability, mobility and radiative properties of the Rabi modes suggest a concept of a self-assembled 2D \textit{% soliton-based nano-antenna}, which should be stable against imperfections In particular, we discuss the implementation of such a nano-antenna in the form of surface plasmon solitons in graphene, and illustrate possibilities to control their operation by means of optical tools.
description: accepted by Journal of Physics: Condensed Matter
Food Price and Diet and Health Outcomes: 20 Years of the CARDIA Study
Creators: name: Shikany, James M.
name: Gordon-Larsen, Penny
name: Jacobs Jr., David R.
name: Duffey, Kiyah J.
name: Guilkey, David
name: Popkin, Barry M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Despite surging interest in taxation as a policy to address poor food choice, US research directly examining the association of food prices with individual intake is scarce.
Cost-Utility of Aspirin and Proton Pump Inhibitors for Primary Prevention
Creators: name: Earnshaw, Stephanie R.
name: Pignone, Michael
name: Scheiman, James
name: McDade, Cheryl
name: Fendrick, A. Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Aspirin reduces myocardial infarction but increases gastrointestinal bleeding. Proton pump inhibitors (PPIs) may reduce upper gastrointestinal bleed. We estimate the cost-utility of aspirin treatment with or without PPI for coronary heart disease (CHD) prevention among men at different risks for CHD and gastrointestinal bleed.
title: Hepatorenal ablation beyond malignant tumours: thermal ablation of benign lesions
Creators: name: Arias L., Maria Eugenia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Abdomen
subject: Fluoroscopy
subject: Percutaneous
subject: Ultrasound
subject: Ablation procedures
subject: Haemangioma
subject: Cysts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Objectives: The aim of this paper is to show our experiencewith percutaneous thermal ablation in the treatment of benign lessions as an alternative to surgery. Liver hemangiomas, liver hydatidic cysts and kidney Angiomyolipomas (AML) have been...
Wavefront Curvature in Optical Atomic Beam Clocks
Creators: name: Strathearn, A.
name: Offer, R. F.
name: Hilton, A. P.
name: Klantsataya, E.
name: Luiten, A. N.
name: Anderson, R. P.
name: Sparkes, B. M.
name: Stace, T. M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Atomic clocks provide a reproducible basis for our understanding of time and frequency. Recent demonstrations of compact optical clocks, employing thermal atomic beams, have achieved short-term fractional frequency instabilities in the $10^{-16}$, competitive with the best international frequency standards available. However, a serious challenge inherent in compact clocks is the necessarily smaller optical beams, which results in rapid variation in interrogating wavefronts. This can cause inhomogeneous excitation of the thermal beam leading to long term drifts in the output frequency. Here we develop a model for Ramsey-Bordé interferometery using optical fields with curved wavefronts and simulate the $^{40}$Ca beam clock experiment described in [Olson et al., Phys. Rev. Lett. 123, 073202 (2019)]. Olson et al.'s results had shown surprising and unexplained behaviour in the response of the atoms in the interrogation. Our model predicts signals consistent with experimental data and can account for the significant sensitivity to laser geometry that was reported. We find the signal-to-noise ratio is maximised when the laser is uncollimated at the interrogation zones to minimise inhomogeneity, and also identify an optimal waist size determined by both laser inhomogeneity and the velocity distribution of the atomic beam. We investigate the shifts and stability of the clock frequency, showing that the Gouy phase is the primary source of frequency variations arising from laser geometry.
description: 13 pages, 7 figures
title: The FLT3 tyrosine kinase receptor ITD mutation controls its expression and drug resistance in acute myeloid leukaemia
Creators: name: Alqahtani, Taha
Publisher: name: University of Liverpool Repository
Year: 2021

description: In approximately 23% of AML patients, Fms-like tyrosine kinase 3 (FLT3) contains a gain-of-function, internal tandem duplication (ITD) mutation that is associated with an unfavourable prognosis. FLT3 is therefore seen as a promising therapeutic avenue for AML and as a result, a more complete understanding of its function and signalling may lead to additional targets and resistance mechanisms being identified. To date, several FLT3 inhibitors including Quizartinib (AC220), a second-generation ITD-selective tyrosine kinase inhibitor, have been developed, but single-agent clinical trials have not been overwhelmingly successful. In most preclinical studies, the inhibitory effects of FLT3 inhibitors are mainly evaluated using mutant-expressing models, however, most AML patients harbour both a wild-type and mutant FLT3 allele as well as presenting with high plasma levels of FLT3 ligand (FLT3L). We hypothesized that FLT3L could act through WT-FLT3 to influence the efficacy of FLT3 inhibitors in cells with heterozygous mutations. In this study, we have examined the role of FLT3 inhibition and FLT3L activation on the cellular localisation and downstream signalling in several AML cell lines, some of which express ITD mutations. We also looked at mechanisms by which FLT3L could impair the efficacy of FLT3 inhibitors. Our results revealed that the majority of FLT3 in the MV4-11 and MOLM-13 cells was intracellular. Inhibition of ITD-FLT3 with quizartinib led to a dramatic relocalisation of FLT3 to the cell surface. This effect was more pronounced in MV4-11 (FLT3ITD/ITD) than the heterozygous MOLM-13 (FLT3ITD/WT) cells that also express WT. This was accompanied by inhibition of ERK, AKT and STAT5 signalling pathways and resulted in cell death. Quizartinib induced cell death only in AML lines expressing FLT3-ITD mutations (MOLM-13 and MV4-11), and this could be antagonised by FLT3 ligand (FLT3L). The largest inhibitory effects were seen in heterozygous cells expressing a mutated and wild-type allele. FLT3 inhibition was associated with downregulation of the anti-apoptotic protein Mcl-1 and upregulation of the pro-apoptotic BH3-only protein, Bim. Our experiments indicated that both of these proteins were regulated by both WT and ITD-FLT3 through the MAPK pathway. These results suggest that activation of FLT3 signalling by FLT3L confers resistance to quizartinib through upregulation of Mcl-1 and suppression of Bim expression. Taken together, our data suggest that FLT3 cell surface localisation and expression are controlled by ITD mutations and are key components of drug resistance. The data also suggests a novel therapeutic approach in patients with high plasma FLT3L levels, especially when using type II inhibitors such as quizartinib, is to co-target the MAPK/ERK pathway to abrogate the FLT3L-mediated resistance in FLT3-ITD AML.
Radio Timing and Optical Photometry of the Black Widow System PSR J1953+1846A in the Globular Cluster M71
Creators: name: Cadelano, M.
name: Pallanca, C.
name: Ferraro, F. R.
name: Stairs, I.
name: Ransom, S. M.
name: Dalessandro, E.
name: Lanzoni, B.
name: Hessels, J. W. T.
name: Freire, P. C. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report on the determination of the astrometric, spin and orbital parameters for PSR J1953+1846A, a "black widow" binary millisecond pulsar in the globular cluster M71. By using the accurate position and orbital parameters obtained from radio timing, we identified the optical companion in ACS/Hubble Space Telescope images. It turns out to be a faint (m_F606W>=24, m_F814W>=23) and variable star located at only ~0.06" from the pulsar timing position. The light curve shows a maximum at the pulsar inferior conjunction and a minimum at the pulsar superior conjunction, thus confirming the association with the system. The shape of the optical modulation suggests that the companion star is heated, likely by the pulsar wind. The comparison with the X-ray light curve possibly suggests the presence of an intra-binary shock due to the interaction between the pulsar wind and the material released by the companion. This is the second identification (after COM-M5C) of an optical companion to a black widow pulsar in a globular cluster. Interestingly, the two companions show a similar light curve and share the same position in the color magnitude diagram.
description: Accepted for publication by ApJ; 33 Pages, 10 Figures, 3 Tables
title: ARFI elastography in ureteropelvic junction obstruction
Creators: name: Üre Esmerer, Emel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Kidney
subject: Urinary Tract / Bladder
subject: Paediatric
subject: Ultrasound
subject: Elastography
subject: Pyelography
subject: Congenital
subject: Obstruction / Occlusion

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: We aim to investigate the role of acoustic radiation force impulse (ARFI) elastography in the detection of renal parenchymal damage in kidneys with and without ureteropelvic junction obstruction...
Fast Food Restaurants and Food Stores: Longitudinal Associations With Diet in Young to Middle-aged Adults: The CARDIA Study
Creators: name: Lewis, Cora E.
name: Boone-Heinonen, Janne
name: Kiefe, Catarina I.
name: Shikany, James M.
name: Popkin, Barry M.
name: Gordon-Larsen, Penny
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A growing body of cross-sectional, small-sample research has led to policy strategies to reduce food deserts – neighborhoods with little or no access to healthy foods – by limiting fast food restaurants and small food stores and increasing access to supermarkets in low-income neighborhoods.
(100900) Mourant Brock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Production of Zero-Carbon Fuel in Microfluidic Reactors by Heterogeneous Catalysis
Creators: name: Maleki, Hesam
Publisher: name: University of Liverpool Repository
Year: 2026

description: In this thesis, the main goal is to design and optimise a microfluidic system for the onboard COx-free generation of hydrogen. The studies were conducted on the synthesis and inkjet printing of mesoporous mixed oxide catalysts into microchannels for hydrogen generation via the low-temperature decomposition of ammonia. The kinetic study of the above reaction was carried out using a combination of experimental and numerical approaches. For the experimental section, a series of procedures was adopted such as advanced material synthesis and deposition, reactor design and characterisation techniques to prepare and characterise novel catalysts and perform kinetic studies in a microreactor. CFD modelling was then carried on the designed reactors, and two kinetic rate models were developed based on the experimental data obtained in the reactor tests. Here, it was demonstrated that inkjet printing could be effectively used for the synthesis and local immobilisation of active catalysts in the reactor systems. Based on the prior literature and this work, a mini-review article was published in the journal of RSC Catal. Sci. Technol., 2020, providing an insight into inkjet printing technology in the context of heterogeneous catalysis. To prove the concept, a low-temperature process (below 100 °C) was used to synthesise and print photoactive anatase nanofilms onto polymeric substrates using a modified desktop inkjet printer. The coated substrates were assembled in a flexible, lightweight microfluidic device for photocatalytic studies. The synthesised TiO2 showed a competitive activity compared with commercial TiO2 nanopowders (published in ACS Appl. Nano Mater., 2019).