cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Boletín 17 – Votos y estratos: impacto en las elecciones locales colombianas (2007 – 2019)
Creators: name: Basset, Yann
name: Fonseca Sandoval, Sara
name: López, Manuel
name: Castaño, Juan Felipe
name: Rojas, Paula
name: Jiménez, Isabela
name: Palacios, Santiago
name: Pinto, Juan Manuel
name: Petro Larrota, Claudio Felipe
name: Rojas, Ana María
name: Hoyos, Juan David
name: Dájer Riveros, Gabriela
name: Ballesteros, Simón
Publisher: name: Universidad del Rosario
Year: 2023

description: Hoy pareciera que hablar en términos de clase es obsoleto, pues han surgido otra serie de categorías que pretenden captar de mejor manera las particularidades de los individuos. Además, la lucha de clase que, según Marx, determinaría el rumbo de la Historia ha sido desplazada (aparentemente) por las cuestiones identitarias. Sin embargo, pese a la resistencia de algunos, las condiciones materiales siguen siendo determinantes de los comportamientos, las creencias y, por supuesto, las preferencias políticas de los individuos. Bajo estas consideraciones, este estudio pretende analizar cómo votan los distintos estratos sociales en las elecciones locales de las principales ciudades del país desde 2007 hasta 2019. En tal propósito se parte de la comprensión del voto como un fenómeno colectivo, por lo que su estudio es posible a través del análisis del comportamiento agregado de los individuos. Por tanto, con la intención de poder identificar la clase social a la que pertenecen los votantes se tomará como referencia el estrato social predominante en los inmuebles aledaños a los puestos de votación, Dado que, la estratificación de los predios ha sido una herramienta de planificación urbana que se ha adoptado en Colombia con el fin de clasificar los inmuebles según las vías de acceso, los servicios y el equipamiento urbano con el que cuentan. La norma general es que las personas habiten inmuebles de acuerdo con su capacidad adquisitiva y a que voten en un lugar cerca de su residencia. Aunque pueden existir excepciones a la generalidad planteada, no se consideran significativas. De esta forma, utilizamos en este estudio el estrato socioeconómico de los barrios aledañosos al puesto de votación como proxy de la clase social de los ciudadanos que ahí votan. Con todas las imprecisiones que esto supone, veremos que los resultados que ofrecemos acá son bastante significativos y apuntan a una lógica de voto “de clase” en las grandes ciudades colombianas.
Spin liquid phase of the $S=\frac{1}{2}$ $J_1-J_2$ Heisenberg model on the triangular lattice
Creators: name: Zhu, Zhenyue
name: White, Steven R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the $S=1/2$ Heisenberg model on the triangular lattice with nearest neighbor interaction $J_1$ and next nearest neighbor interaction $J_2$ with the density matrix renormalization group. We are able to study long open cylinders with widths up to 9 lattice spacings. At an intermediate $J_2$ region $0.06 \lesssim J_2/J_1 \lesssim 0.17$, we find evidence for a spin liquid (SL) state with short range spin-spin, bond-bond and chiral correlation lengths, bordered by a classical $120^\circ$ Néel ordered state at small $J_2$ and by a two sub-lattice collinear magnetically ordered state at larger $J_2$. Focusing on $J_2/J_1 = 0.1$, we find a number of signatures of a gapped SL phase: two quasi-degenerate ground states on even cylinders, with an energy gap that decreases exponentially with the cylinder width; a dimerization effect on odd cylinders; and large spin triplet and singlet bulk gaps.
description: 5+4 pages, 4+7 figures, 1 table. v2 minor changes made for publication on PRB rapid communication
Katholizismus und Gemeinschaft der Heiligen
Creators: name: Balthasar, Hans Urs Von
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 17 Nr. 1 (1988): Internationale katholische Zeitschrift Communio, Band 17, Heft 1
In Vivo Particle Uptake by Airway Macrophages in Healthy Volunteers
Creators: name: Alexis, Neil E.
name: Zeman, Kirby L.
name: Geiser, Marianne
name: Kapp, Nadine
name: Lay, John C.
name: Bennett, William D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: We combined two techniques, radiolabeled aerosol inhalation delivery and induced sputum, to examine in vivo the time course of particle uptake by airway macrophages in 10 healthy volunteers. On three separate visits, induced sputum was obtained 40, 100, and 160 min after inhalation of radiolabeled sulfur colloid (SC) aerosol (Tc99 m-SC, 0.2 μm colloid size delivered in 6-μm droplets). On a fourth visit (control) with no SC inhalation, induced sputum was obtained and SC particles were incubated (37°C) in vitro with sputum cells for 40, 100, and 160 min (matching the times associated with in vivo sampling). Total and differential cell counts were recorded for each sputum sample. Compared with 40 min (6 ± 3%), uptake in vivo was significantly elevated at 100 (31 ± 5%) and 160 min (27 ± 4%); both were strongly associated with the number of airway macrophages (R = 0.8 and 0.7, respectively); and the number and proportion of macrophages at 40 min were significantly (P < 0.05) elevated compared with control (1,248 ± 256 versus 555 ± 114 cells/mg; 76 ± 6% versus 60 ± 5%). Uptake in vitro increased in a linear fashion over time and was maximal at 160 min (40 min, 12 ± 2%; 100 min, 16 ± 4%; 160 min, 24 ± 6%). These data suggest that airway surface macrophages in healthy subjects rapidly engulf insoluble particles. Further, macrophage recruitment and phagocytosis-modifying agents are factors in vivo that likely affect particle uptake and its time course.
Pulmonary Immune Responses to Propionibacterium acnes in C57BL/6 and BALB/c Mice
Creators: name: McCaskill, Joshua G.
name: Ghio, Andrew J.
name: Neuringer, Isabel P.
name: Funkhouser, William K.
name: Hua, Xiaoyang
name: Tilley, Stephen L.
name: Chason, Kelly D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Propionibacterium acnes (PA) is a gram-positive anaerobic bacterium implicated as a putative etiologic agent of sarcoidosis. To characterize the pulmonary immune response to PA, C57BL/6 and BALB/c mice were intraperitoneally sensitized and intratracheally challenged with heat-killed bacteria. C57BL/6 mice challenged with PA developed a cellular immune response characterized by elevations in Th1 cytokines/chemokines, increased numbers of lymphocytes and macrophages in lung lavage fluid, and peribronchovascular granulomatous inflammation composed of T- and B-lymphocytes and epithelioid histiocytes. T-lymphocytes in the lung lavage fluid showed a marked CD4+ cell predominance. In contrast, C57BL/6 mice challenged with Staphylococcus epidermidis (SE), another gram-positive commensal of human skin, and BALB/c mice challenged with PA, showed only a modest induction of Th1 cytokines, less pulmonary inflammation, and no granulomatous changes in the lung. Enhancement of Toll-like receptor expression was seen in PA-exposed C57BL/6 mice within 24 h after exposure, suggesting that induction of innate immunity by PA contributes to the robust, polarized Th1 immune response elicited by this bacterium. These findings suggest that PA-induced pulmonary inflammation may be a useful model for testing the contributions of both bacterial and host factors in the development, maintenance, and resolution of granulomatous inflammation in the lung.
Additional file 3: of Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Creators: name: Wiechmann, Tobias
name: Röh, Simone
name: Sauer, Susann
name: Czamara, Darina
name: Arloth, Janine
name: Ködel, Maik
name: Beintner, Madita
name: Knop, Lisanne
name: Menke, Andreas
name: Binder, Elisabeth
name: Provençal, Nadine
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Figure S3. CpG sites with significant genotype-dependent dynamic methylation differences in both studies. Effects of rs1360780 genotype on DEX-induced DNA methylation changes in 2 sites located in intron 7 and 5 enhancers. The % methylation levels for rs1360780 risk allele carriers CT/TT and CC carriers following DEX exposure are shown for each study. Methylation of CpG 35558710 shows significant interaction effect at 23 h in study 1 (Χ2 = 5.69, p value = 0.02) and additive effect at 3 h in study 2 (Χ2 = 4.15, p value = 0.04) with risk allele genotype. Significant interactions between risk allele genotype and DEX on methylation were observed for CpG 35570224 at 6 h and 23 h post-treatment in study 1 (Χ2 = 7.59, p value = 0.006 and Χ2 = 6.0, p value = 0.01) and at 24 h in study 2 (Χ2 = 4.36, p value = 0.04). Points and error bars represent mean and SEM for each genotype. (PDF 101 kb)
Examining the Effects of Prosocial Behavior and Beliefs about Social Media Authenticity on Online Social Justice Posting Behavior
Creators: name: Mullane, Molly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: This study investigated the effects of four types of prosocial behavior (emotional, dire, alternative gain, and public) on the frequency of social justice-related social media posts, and whether these effects were moderated by beliefs about the authenticity of social media. The Default Interventionist Model was used to frame the possible impact of the four types of prosocial behavior and beliefs about social media authenticity on social justice posting behaviors. Female (51.92%) and male (48.08%) adolescents (n=1,614; aged 13-19) reported their frequency of social justice-related postings online, prosocial behaviors, and beliefs about social media authenticity. Participants with high levels of emotional prosocial behavior had a greater frequency of social justice-related social media posts. The study found one moderation effect of beliefs about social media authenticity on the link between prosocial behavior for alternate gain and the frequency of social justice-related postings, with high levels indicating a positive association and low levels a negative association. Thus, one makes more social justice-related posts as they engage in alternative gain prosocial behavior if one has greater beliefs about social media authenticity. However, if one has lower beliefs about social media authenticity, as one engages in prosocial behavior for alternate gain, the frequency of social justice posting decreases.
Boletín 14 - El ejercicio de la oposición en el congreso: un balance general
Creators: name: Basset, Yann
name: Fonseca Sandoval, Sara
name: Gómez, Yarol Esteban
name: Torres Barbosa, Said
name: Pedraza Zapata, Santiago
name: Barreto Ojeda, Sofía
Publisher: name: Universidad del Rosario
Year: 2021

description: A partir de la entrada en vigencia de la ley 1909 de 2018 (Estatuto de la Oposición), además de brindarse numerosas garantías para el ejercicio de la oposición, se consagra la obligación para los partidos políticos de declarar su posición frente al gobierno: Independiente, de gobierno u oposición. Así, el Congreso actual ha sido el primero en funcionar según esta norma. En consecuencia, el propósito de este boletín será analizar algunas variables relacionadas con el ejercicio de la oposición del actual congreso entre 2018 y 2020, a fin de identificar si el hecho de declararse en oposición se relaciona con un comportamiento distinto a la hora de votar en el Congreso. Para ello, se evalúa el rechazo a los proyectos de ley,  a los proyectos de ley de inicitiva gubernamental,  el voto en las mociones de censura,  los temas que mayor oposición generan y  las diferencias en el comportamiento de la oposición entre Cámara y Senado.
Generalized Ginzburg-Landau approach to inhomogeneous phases in nonlocal chiral quark models
Creators: name: Carlomagno, J. P.
name: Dumm, D. Gomez
name: Scoccola, N. N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze the presence of inhomogeneous phases in the QCD phase diagram within the framework of nonlocal chiral quark models. We concentrate in particular in the positions of the tricritical (TCP) and Lifshitz (LP) points, which are studied in a general context using a generalized Ginzburg-Landau approach. We find that for all the phenomenologically acceptable model parametrizations considered the TCP is located at a higher temperature and a lower chemical potential in comparison with the LP. Consequently, these models seem to favor a scenario in which the onset of the first order transition between homogeneous phases is not covered by an inhomogeneous, energetically favored phase.
description: 9 pages, 1 figure. V2: Two references added, figure modified, minor changes in the text introduced. Matches version to be published in Physics Letters B
SERCA Pump Inhibitors Do Not Correct Biosynthetic Arrest of ΔF508 CFTR in Cystic Fibrosis
Creators: name: Van Heeckeren, Anna M.
name: Boucher, Richard C.
name: Knowles, Michael R.
name: Mengos, April
name: Drumm, Mitchell L.
name: Riordan, John R.
name: Gentzsch, Martina
name: Gabriel, Sherif E.
name: Grubb, Barbara R.
name: Randell, Scott H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Deletion of phenylalanine 508 (ΔF508) accounts for nearly 70% of all mutations that occur in the cystic fibrosis transmembrane conductance regulator (CFTR). The ΔF508 mutation is a class II processing mutation that results in very little or no mature CFTR protein reaching the apical membrane and thus no cAMP-mediated Cl− conductance. Therapeutic strategies have been developed to enhance processing of the defective ΔF508 CFTR molecule so that a functional cAMP-regulated Cl− channel targets to the apical membrane. Sarcoplasmic/endoplasmic reticulum calcium (SERCA) inhibitors, curcumin and thapsigargin, have been reported to effectively correct the CF ion transport defects observed in the ΔF508 CF mice. We investigated the effect of these compounds in human airway epithelial cells to determine if they could induce ΔF508 CFTR maturation, and Cl− secretion. We also used Baby Hamster Kidney cells, heterologously expressing ΔF508 CFTR, to determine if SERCA inhibitors could interfere with the interaction between calnexin and CFTR and thereby correct the ΔF508 CFTR misfolding defect. Finally, at the whole animal level, we tested the ability of curcumin and thapsigargin to (1) induce Cl− secretion and reduce hyperabsorption of Na+ in the nasal epithelia of the ΔF508 mouse in vivo, and (2) induce Cl− secretion in intestine (jejunum and distal colon) and the gallbladder of the ΔF508 CF mouse. We conclude that curcumin and thapsigargin failed to induce maturation of ΔF508 CFTR, or induce Cl− secretion, as measured by biochemical and electrophysiologic techniques in a variety of model systems ranging from cultured cells to in vivo studies.
Boletín 10 - Elección de autoridades locales (2019)
Creators: name: Basset, Yann
name: Franco Acosta, Lina María
name: Mora Prieto, Saira Daniela
name: Barreto Abril, Suzanne Gabriela
Publisher: name: Universidad del Rosario
Year: 2019

description: Las elecciones locales del 27 de octubre han develado lo que pareciera ser un nuevo panorama que pone en juego el balance de las fuerzas políticas en el país. Sin embargo, para comprender la proporción de estos “cambios”, es preciso analizar las preferencias de los ciudadanos más allá de las ciudades, en los cerca de 1100 municipios que han votado por los alcaldes, gobernadores, concejales y diputados que ejercerán para el período 2020-2023.
Plasmon-Phonon Hybridization in Doped Semiconductors from First Principles
Creators: name: Lihm, Jae-Mo
name: Park, Cheol-Hwan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Although plasmons and phonons are the collective excitations that govern the low-energy physics of doped semiconductors, their nonadiabatic hybridization and mutual screening have not been studied from first principles. We achieve this goal by transforming the Dyson equation to the frequency-independent dynamical matrix of an equivalent damped oscillator. Calculations on doped GaAs and TiO2 agree well with available Raman data and await immediate experimental confirmation from infrared, neutron, electron-energy-loss, and angle-resolved photoemission spectroscopies.
Mucin granule intraluminal organization in living mucous/goblet cells: Roles of protein post-translational modifications and secretion
Creators: name: Perez-Vilar, Juan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Mucus secretions have played a central role in the evolution of multicellular organisms, enabling adaptation to widely differing environments. In vertebrates, mucus covers and protects the epithelial cells in the respiratory, gastrointestinal, urogenital, visual, and auditory systems, amphibian's epidermis, and the gills in fishes. Deregulation of mucus production and/or composition has important consequences for human health. For example, mucus obstruction of small airways is observed in chronic airway diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis. The major protein component in the mucus is a family of large, disulfide-bonded glycoproteins known as gel-forming mucins. These proteins are accumulated in large, regulated secretory granules (the mucin granules) that occupy most of the apical cytoplasm of specialized cells known as mucous/goblet cells. Since mucin oligomers have contour dimensions larger than the mucin granule average diameter, the question arises how these highly hydrophilic macromolecules are organized within these organelles. I review here the intraluminal organization of the mucin granule in view of our knowledge on the structure, biosynthesis, and biophysical properties of gel-forming mucins, and novel imaging studies in living mucous/goblet cells. The emerging concept is that the mucin granule lumen comprises a partially condensed matrix meshwork embedded in a fluid phase where proteins slowly diffuse.
Recruitment Dynamics and Suggested Role of SPT6 at the Drosophila Histone Locus Body during Early Embryogenesis
Creators: name: Mia Hoover
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Histones are essential for packaging DNA and maintaining genomic stability, with their expression tightly controlled and coupled to the cell cycle. In Drosophila, replication-dependent (RD) histone mRNAs are transcribed from a single locus at which an evolutionarily conserved, phase-separated nuclear body forms — the histone locus body (HLB). Previous work has demonstrated that components are recruited to the HLB in  a cell-cycle dependent, hierarchical manner, with SPT6 established as a dynamic component. Highly-conserved SPT6 is generally considered as a nucleosome remodeler and transcription elongation factor known to bind RNA Pol II, though its roles are not fully understood. Notably, recent work has indicated that SPT6 is not necessary for elongation at short genes, a classification including the RD histone genes. Given the known presence of SPT6 at the HLB, we were curious about its role in HLB formation and  transcription of the RD histone genes. Here, using antibodies and fluorescently-tagged proteins we visualized the spatiotemporal localization of SPT6 at the HLB in developing Drosophila embryos via confocal microscopy. Combining this approach with sensitive FISH probes to detect nascent RD histone transcripts, we examined the relationship between the localization of SPT6 to the HLB and active transcription. From imaging both live and fixed embryos, we found that SPT6 is continuously enriched at the HLB throughout S phase of the syncytial nuclear cycles, yet only transiently present at the HLB during the beginning of nuclear cycle 14. In contrast, unpaused RNA Pol II and nascent histone mRNA remain present at the HLB throughout all of cycle 14, showing an unexpected uncoupling of the association between SPT6 and RNA Pol II during active transcription. These data also suggest that SPT6 may be functioning at the HLB primarily as a nucleosome remodeler rather than a transcription elongation factor.
Boletín 16 – Congreso 2022 – 2026 ¿El Congreso del cambio?
Creators: name: López, Manuel
name: Basset, Yann
name: Fonseca Sandoval, Sara
name: Goyes Enriquez, David
name: Palacios, Santiago
name: Pinto, Juan Manuel
name: Ballesteros, Simón
name: Bermúdez, Juan Andrés
name: Jiménez, Isabela
name: Dájer, Gabriela
name: Petro, Claudio
Publisher: name: Universidad del Rosario
Year: 2022

description: A través del presente trabajo se pretende realizar un perfil del congreso colombiano  elegido en junio de 2022.  A partir de distintos indicadores, se evalúa la conformación de este nuevo congreso en términos de reelección y renovación, la presencia de cacicazgos, la paridad de género y el tránsito hacía el voto en listas cerradas y sin voto preferente.
Observational studies of the bidirectional association between metabolic syndrome and migraine.
Creators: name: Lu, Xu
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medicine and Health Sciences

description: Synthesize the data from all epidemiological studies investigating the bilateral relationship between metabolic syndrome and migraine and conduct a meta-analysis to further clarify the relationship between the two and provide reference for the prevention and treatment of these two diseases.
No Detectable Improvements in Cystic Fibrosis Transmembrane Conductance Regulator by Nasal Aminoglycosides in Patients with Cystic Fibrosis with Stop Mutations
Creators: name: Mayer-Hamblett, Nicole
name: Moss, Rick
name: Zeitlin, Pam
name: Oster, Robert A.
name: Rowe, Steven M.
name: Bebok, Zsuzsa
name: Knowles, Michael R.
name: Ramsey, Bonnie
name: Aitken, Moira L.
name: Gibson, Ron
name: Berclaz, Pierre
name: Clancy, John P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Cystic fibrosis (CF) is an autosomal recessive disorder caused by many types of genetic defects, including premature stop codons. Gentamicin can suppress stop mutations in CF transmembrane conducatnce regulator (CFTR) in vitro and in vivo, leading to improvements in CFTR-dependent ion transport and protein localization to the apical surface of respiratory epithelial cells. The primary objective of this study was to test whether nasally administered gentamicin or tobramycin could suppress premature stop mutations in CFTR, resulting in full-length, functional protein. A secondary objective was to obtain data to aid in the design of multicenter trials using the nasal potential difference as a study endpoint. A multicenter study was conducted in two cohorts of patients with CF, those heterozygous for stop mutations in the CFTR gene and those without nonsense mutations, to investigate the effects of both gentamicin and tobramycin administered over a 28-d period on sequential nasal potential difference and airway cell immunofluorescence endpoints. Eleven patients with CF with stop mutations were enrolled in a randomized, double-blinded, crossover fashion to receive each drug, while 18 subjects with CF without stop mutations were randomized 1:1 in a parallel fashion to receive one drug. After demonstration of drug delivery, neither aminoglycoside produced detectable changes in nasal ion transport or CFTR localization in brushed cells from either study group. These results with first-generation suppressive agents suggest the need for improved drug delivery methods and/or more potent suppressors of nonsense mutations to confer CFTR correction in subjects with CF heterozygous for nonsense mutations. The study provides valuable information on parameters of the nasal potential difference measurements for use in future multicenter clinical trials.
Post-Infection A77-1726 Blocks Pathophysiologic Sequelae of Respiratory Syncytial Virus Infection
Creators: name: Lazarowski, Eduardo R.
name: Hickman-Davis, Judy M.
name: Matalon, Sadis
name: Sullender, Wayne M.
name: Chen, Fu-Ping
name: Davis, Ian C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Despite respiratory syncytial virus (RSV) bronchiolitis remaining the most common cause of lower respiratory tract disease in infants worldwide, treatment has progressed little in the past 30 years. The aim of our study was to determine whether post-infection administration of de novo pyrimidine synthesis inhibitors could prevent the reduction in alveolar fluid clearance (AFC) and hypoxemia that occurs at Day 2 after intranasal infection of BALB/c mice with RSV. BALB/c mice were infected intranasally with RSV strain A2. AFC was measured in anesthetized, ventilated mice after instillation of 5% bovine serum albumin into the dependent lung. Post-infection systemic treatment with leflunomide has no effect on AFC. However, when added to the AFC instillate, leflunomide's active metabolite, A77-1726, blocks RSV-mediated inhibition of AFC at Day 2. This block is reversed by uridine (which allows pyrimidine synthesis via the scavenger pathway) and not recapitulated by genistein (which mimics the tyrosine kinase inhibitor effects of A77-1726), indicating that the effect is specific for the de novo pyrimidine synthesis pathway. More importantly, when administered intranasally at Day 1, A77-1726, but not its vehicle dimethyl sulfoxide, maintains its beneficial effect on AFC and lung water content until Day 2. Intranasal instillation of A77-1726 at Day 1 also reduces bronchoalveolar lavage nucleotide levels, lung inflammation, and hypoxemia at Day 2 without impairing viral replication at Day 2 or viral clearance at Day 8. Post-infection intranasal or aerosolized treatment with pyrimidine synthesis inhibitors may provide symptomatic relief from the pathophysiologic sequelae of impaired AFC in children with RSV bronchiolitis.
String theory in AdS_3 x S^3 x T^4 with mixed flux: semiclassical and 1-loop phase in the S-matrix
Creators: name: Stepanchuk, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a semiclassical derivation of the tree-level and 1-loop dressing phases in the massive sector of string theory on AdS_3 x S^3 x T^4 supplemented by R-R and NS-NS 3-form fluxes. In analogy with the AdS_5 x S^5 case, we use the dressing method to obtain scattering solutions for dyonic giant magnons which allows us to determine the semiclassical bound-state S-matrix and its 1-loop correction. We also find that the 1-loop correction to the dyonic giant magnon energy vanishes. Looking at the relation between the bound-state picture and elementary magnons in terms of the fusion procedure we deduce the elementary dressing phases. In both the semiclassical and 1-loop cases we find agreement with recent proposals from finite-gap equations and unitarity cut methods. Further, we find consistency with the finite-gap picture by determining the resolvent for the dyonic giant magnon from the semiclassical bosonic scattering data.
description: 28 pages. v2: references added, v3: extended introduction
title: SSMSPC: self-supervised multivariate statistical in-process control in discrete manufacturing processes
Creators: name: Biegel, Tobias
name: Helm, Patrick
name: Jourdan, Nicolas
name: Metternich, Joachim
Publisher: name: Springer
Year: 2025

description: Self-supervised learning has demonstrated state-of-the-art performance on various anomaly detection tasks. Learning effective representations by solving a supervised pretext task with pseudo-labels generated from unlabeled data provides a promising concept for industrial downstream tasks such as process monitoring. In this paper, we present SSMSPC a novel approach for multivariate statistical in-process control (MSPC) based on self-supervised learning. Our motivation for SSMSPC is to leverage the potential of unsupervised representation learning by incorporating self-supervised learning into the general statistical process control (SPC) framework to develop a holistic approach for the detection and localization of anomalous process behavior in discrete manufacturing processes. We propose a pretext task called Location + Transformation prediction, where the objective is to classify both, the type and the location of a randomly applied augmentation on a given time series input. In the downstream task, we follow the one-class classification setting and apply the Hotelling’s T² statistic on the learned representations. We further propose an extension to the control chart view that combines metadata with the learned representations to visualize the anomalous time steps in the process data which supports a machine operator in the root cause analysis. We evaluate the effectiveness of SSMSPC with two real-world CNC-milling datasets and show that it outperforms state-of-the-art anomaly detection approaches, achieving 100% and 99.6% AUROC, respectively. Lastly, we deploy SSMSPC at a CNC-milling machine to demonstrate its practical applicability when used as a process monitoring tool in a running process.
Additional file 1: of Onchocerciasis-associated epilepsy: another piece in the puzzle from the Mahenge mountains, southern Tanzania
Creators: name: Kaiser, Christoph
name: Mmbando, Bruno
name: Fodjo, Joseph Siewe
name: Suykerbuyk, Patrick
name: Mnacho, Mohamed
name: Advocatus Kakorozya
name: Matuja, William
name: Hendy, Adam
name: Greter, Helena
name: Williams Makunde
name: Colebunders, Robert
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Multilingual abstracts in the five official working languages of the United Nations. (PDF 488 kb)
Neurogenetic Effects of Pharmacological G9a Inhibition on Alzheimer’s Disease in Early-Onset Alzheimer’s Diseased Mice
Creators: name: Murray, Taylor
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Alzheimer’s Disease (AD) is popularly known for its onset and progression of memory deficits and executive dysfunction, often leading to dementia and other facets of cognitive decline. Many researchers have emphasized the involvement of tau proteins and aspects of neuroinflammation as leading causes of AD. However, the possible genetic component contributing to the disease has not been widely studied. Studies have shown histone methyltransferases, and more specifically a molecule known as G9a, to be a key component in the decline of neurogenesis and the subsequent progression of AD. Here we employ a novel G9a inhibitor to investigate its effect on neurogenesis in 5XFAD mice (early onset AD mice), namely on proliferation cells and immature neurons. Surprisingly, we reflect no significant difference in neurogenesis between control and treatment groups. Further, factors contributing to the confounding results in this paper are also discussed.
A 2B Adenosine Receptors Regulate the Mucus Clearance Component of the Lung's Innate Defense System
Creators: name: Rollins, Brett M.
name: Clunes, Mark T.
name: Lethem, Michael I.
name: Chambers, Lucy A.
name: Hirsh, Andrew J.
name: Burn, Mellisa
name: Donaldson, Scott H.
name: Coakley, Ray D.
name: Tarran, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Adenosine (ADO) signaling is altered in both asthma and chronic obstructive pulmonary disease, and the A2B adenosine receptor (A2B-R) may drive pulmonary inflammation. Accordingly, it has been proposed that specific inhibition of the A2B-R could treat inflammatory lung diseases. However, stimulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by ADO may be crucial in permitting the superficial epithelium to maintain airway surface liquid (ASL) volume, which is required to ensure hydrated and clearable mucus. Our goal was to determine which ADO receptor (ADO-R) underlies ASL volume regulation in bronchial epithelia. We used PCR techniques to determine ADO-R expression in bronchial epithelia and used nasal potential difference measurements, Ussing chambers studies, and XZ-confocal microscopy to look at Cl- secretion and ASL volume regulation. The A2B-R was the most highly expressed ADO-R in donor specimens of human bronchial epithelia, and inhibition of ADO-R in vivo prevented activation of CFTR. A2B-R was the only ADO-R detected in cultured human bronchial epithelial cells and inhibition of this receptor with specific A2B-R antagonists resulted in ASL height collapse and a failure to effect ASL height homeostasis. Removal of ADO with ADO deaminase and replacement with 5′N-ethylcarboxamide adenosine resulted in dose-dependent changes in ASL height, and suggested that the cell surface (ADO) may be in excess of 1 μM, which is sufficient to activate A2B-R. A2B-R are required for ASL volume homeostasis in human airways, and therapies directed at inhibiting A2B-R may lead to a cystic fibrosis–like phenotype with depleted ASL volume and mucus stasis.
Lepton-Flavored Dark Matter
Creators: name: Kile, Jennifer
name: Kobach, Andrew
name: Soni, Amarjit
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work, we address two paradoxes. The first is that the measured dark-matter relic density can be satisfied with new physics at O(100 GeV - 1 TeV), while the null results from direct-detection experiments place lower bounds of O(10 TeV) on a new-physics scale. The second puzzle is that the severe suppression of lepton-flavor-violating processes involving electrons, e.g. mu->3e, tau->e mu mu, etc., implies that generic new-physics contributions to lepton interactions cannot exist below O(10 - 100 TeV), whereas the 3.6sigma deviation of the muon g-2 from the standard model can be explained by a new-physics scale < O(1 TeV). Here, we suggest that it may not be a coincidence that both the muon g-2 and the relic density can be satisfied by a new-physics scale < 1 TeV. We consider the possibility of a gauged lepton-flavor interaction that couples at tree level only to mu- and tau-flavored leptons and the dark sector. Dark matter thus interacts appreciably only with particles of mu and tau flavor at tree level and has loop-suppressed couplings to quarks and electrons. Remarkably, if such a gauged flavor interaction exists at a scale O(100 GeV - 1 TeV), it allows for a consistent phenomenological framework, compatible with the muon g-2, the relic density, direct detection, indirect detection, charged-lepton decays, neutrino trident production, and results from hadron and e+e- colliders. We suggest experimental tests for these ideas at colliders and for low-energy observables.
description: includes additional discussions, results unchanged
Boletín 13 - La oposición en Colombia desde un enfoque local
Creators: name: Basset, Yann
name: Franco Acosta, Lina María
name: Patiño, Juan Diego
name: Murillo, Amanda
name: Beltrán, Diego Alejandro
name: Dimey, Gustavo
name: Pérez, Juan Sebastián
name: Díaz, Maria Gabriela
name: García, Natalia
name: Gómez, Patricia
Publisher: name: Universidad del Rosario
Year: 2021

description: Los Acuerdos de Paz de la Habana y el Estatuto de la oposición constituyen un avance para que el ejercicio de la oposición en Colombia se vuelva un mecanismo profundizador de nuestra democracia. Hasta ahora, el foco de los análisis se mantiene sobre el ejercicio de la oposición a nivel nacional, por lo cual hemos querido observar el fenómeno desde otra perspectiva. Exploraremos entonces las preguntas: ¿Cómo se comportan los partidos en lo local? ¿Dónde y en qué formas se presenta laoposición municipal?
An Energy-Conserving Hair Shading Model Based on Neural Style Transfer
Creators: name: Qiao, Zhi
name: Kanai, Takashi
Publisher: name: The Eurographics Association
Year: 2020
Subjects: Computing methodologies
Image based rendering
Neural networks

description: We present a novel approach for shading photorealistic hair animation, which is the essential visual element for depicting realistic hairs of virtual characters. Our model is able to shade high-quality hairs quickly by extending the conditional Generative Adversarial Networks. Furthermore, our method is much faster than the previous onerous rendering algorithms and produces fewer artifacts than other neural image translation methods. In this work, we provide a novel energy-conserving hair shading model, which retains the vast majority of semi-transparent appearances and exactly produces the interaction with lights of the scene. Our method is effortless to implement, faster and computationally more efficient than previous algorithms.
description: Pacific Graphics Short Papers, Posters, and Work-in-Progress Papers
description: Rendering
description: 1
description: 6
description: Zhi Qiao and Takashi Kanai
description: CCS Concepts: Computing methodologies --> Image-based rendering; Neural networks
MOESM2 of Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy
Creators: name: C. Hoey
name: M. Ahmed
name: A. Fotouhi Ghiam
name: D. Vesprini
name: X. Huang
name: K. Commisso
name: A. Commisso
name: J. Ray
name: E. Fokas
name: D. Loblaw
name: H. He
name: S. Liu
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 2: Table S2. miRNA mimic sequences for control, miR-17, miR-20a, miR-20b and miR-106a that were used in in vitro validation studies. Sequences provided in 5â   â   3â   orientation.
TeV $γ$-ray fluxes from the long campaigns on Mrk421 as constraints on the emission of TeV-PeV Neutrinos and UHECRs
Creators: name: Fraija, Nissim
name: Marinelli, Antonio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Long TeV $γ$-ray campaigns have been carried out to study the spectrum, variability and duty cycle of the BL Lac object Markarian 421. These campaigns have given some evidence of the presence of protons in the jet: i) Its spectral energy distribution which shows two main peaks; one at low energies ($\sim$ 1 keV) and the other at high energies (hundreds of GeV), has been described by using synchrotron proton blazar model. ii) The study of the variability at GeV $γ$-rays and X-rays has indicated no significant correlation. iii) TeV $γ$-ray detections without activity in X-rays, called "orphan flares" have been observed in this object.\\ Recently, The Telescope Array Collaboration reported the arrival of 72 ultra-high-energy cosmic rays with some of them possibly related to the direction of Markarian 421. The IceCube Collaboration reported the detection of 37 extraterrestrial neutrinos in the TeV - PeV energy range collected during three consecutive years. In particular, no neutrino track events were associated with this source. In this paper, we consider the proton-photon interactions to correlate the TeV $γ$-ray fluxes reported by long campaigns with the neutrino and ultra-high-energy cosmic ray observations around this blazar. Considering the results reported by The IceCube and Telescope Array Collaborations, we found that only from $\sim$ 25\% to 70\% of TeV fluxes described with a power law function with exponential cutoff can come from the proton-photon interactions.
description: Accepted for publication in Astroparticle Physics (12 pages, 4 figures)
Self-consistent electron lifetimes for electron-phonon scattering
Creators: name: Lihm, Jae-Mo
name: Poncé, Samuel
name: Park, Cheol-Hwan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Acoustic phonons in piezoelectric materials strongly couple to electrons through a macroscopic electric field. We show that this coupling leads to a momentum-dependent divergence of the Fan-Migdal electron linewidth. We then develop a self-consistent theory for calculating electron linewidths, which not only removes this piezoelectric divergence but also considerably modifies the linewidth in nonpiezoelectric, polar materials. Our predictions await immediate experimental confirmation, and this self-consistent method should be broadly used in interpreting various experiments on the electronic properties of real materials.
Boletín 9 - Renovación y permanencia en el Congreso de la República (2018)
Creators: name: Basset, Yann
name: López, Daniel Felipe
name: Girón, Carlos Fernando
name: Valencia, Alejandra
name: Castro, Juan José
name: Cifuentes, Angelo
name: Patiño, Juan Diego
name: Guzman, Juan Pablo
Publisher: name: Universidad del Rosario
Year: 2019

description: Las elecciones del Congreso del 2018 tuvieron la mayor participación en unos comicios legislativos desde 1991. A pesar de esto, el Congreso es percibido de manera negativa en las encuestas de opinión. Se le critica, entre otras, la falta de renovación y el inmovilismo. ¿Qué tan verdadera es esta apreciación? ¿El Congreso del 2018 es una fiel copia de la misma corporación en 2014? Además de analizar los porcentajes de renovación en la corporación, se analizan casos de cacicazgos, padrinazgos y participación de la mujeres en el Congreso.
MOESM4 of Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy
Creators: name: C. Hoey
name: M. Ahmed
name: A. Fotouhi Ghiam
name: D. Vesprini
name: X. Huang
name: K. Commisso
name: A. Commisso
name: J. Ray
name: E. Fokas
name: D. Loblaw
name: H. He
name: S. Liu
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 4: Table S3. Differential expression analysis of circulating serum miRNAs in low-risk vs high-risk patients. padj, p-value corrected for multiple testing using Bonferroni method.
Jane Austen's Simpletons: Gender, Education, and Matrimony in Austen's Novels
Creators: name: Danielle N. Richmond
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: This study of Jane Austen’s literary style analyzes the twelve total occurrences of the word ‘simpleton’ across Austen’s mature body of work. Addressing the previous lack of attention to Austen’s use of insults, this study aims to explore her treatment of the mild insult ‘simpleton’ in context to increase our understanding of her views on gender, education, and matrimony. Austen frequently uses this word to illuminate nuances about the place of artifice and manipulation in courtship, the balance between prudence and affection, and the importance of marrying for love and security. The instances differ according to who uses them, who is being insulted, and if it is used ironically by the character or the author.

This study supports the assertions by Mary Lascelles, Norman Page, and Stuart Tave, among others, that Austen was consistently intentional with her diction. Unlike previous approaches to studying Austen’s diction, this study analyzes how Austen’s use of a single word across her body of work is a microcosm of her larger views of society. Proceeding chronologically, this approach shows that Austen’s use of ‘simpleton’ became more complicated as her opinions of women’s societal role became more nuanced. This study is the first to follow a term of insult across Austen’s body of work and the first study of the word ‘simpleton’ across Austen’s oeuvre.
Misner-Sharp Mass and the Unified First Law in Massive Gravity
Creators: name: Hu, Ya-Peng
name: Zhang, Hongsheng
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We obtain the Misner-Sharp mass in the massive gravity for a four dimensional spacetime with a two dimensional maximally symmetric subspace via the inverse unified first law method. Significantly, the stress energy is conserved in this case with a widely used reference metric. Based on this property we confirm the derived Misner-Sharp mass by the conserved charge method. We find that the existence of the Misner-sharp mass in this case does not lead to extra constraint for the massive gravity, which is notable in modified gravities. In addition, as a special case, we also investigate the Misner-Sharp mass in the static spacetime. Especially, we take the FRW universe into account for investigating the thermodynamics of the massive gravity. The result shows that the massive gravity can be in thermodynamic equilibrium, which fills in the gap in the previous studies of thermodynamics in the massive gravity.
description: 11 pages, no figure, version published in PRD
Holographic charge diffusion in non relativistic branes
Creators: name: Roychowdhury, Dibakar
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, based on the principles of gauge/gravity duality and considering the so called \textit{hydrodynamic} limit we compute various charge transport properties for a class of strongly coupled non relativistic CFTs corresponding to $ z=2 $ fixed point whose dual gravitational counter part could be realized as the consistent truncation of certain non relativistic $ Dp $ branes in the non extremal limit. From our analysis we note that unlike the case for the AdS black branes, the charge diffusion constant in the non relativistic background scales differently with the temperature. This shows a possible violation of the universal bound on the charge conductivity to susceptibility ratio in the context of non relativistic holography.
description: 13 pages, clarificatons added, Version to appear in Physics Letters B
Boletín 15 – Elecciones legislativas 2022: balance por partido y comparativo con 2018
Creators: name: Jiménez Montes, Isabela
name: Maturana, Patricia
name: Pinto, Juan Manuel
name: Montaño, Carolina
name: Hoyos, Juan David
name: Ortiz, María Paula
name: Saldaña, María Camila
name: Basset, Yann
name: Fonseca Sandoval, Sara
name: Tamayo, Luisa Fernanda
name: Torres Barbosa, Said
name: Palacios Gómez, Santiago
Publisher: name: Universidad del Rosario
Year: 2023

description: El documento tiene como objetivo analizar el resultado de  las elecciones legislativas de 2022 y realizar un comparativo con los resultados obtenidos en 2018, así como evaluar los factores que contribuyeron  a este resultado.