cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optimized on-Line Control of MMA Polymerization using Fast Multi-Objective DE
Creators: name: Vibhu Trivedi
name: Prakash, Shiv
name: Manojkumar Ramteke
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Optimized on-line control (OOC) of polymerization reactors combines the optimization with the on-line operation and control. In this, re-optimized control variable trajectories, in the presence of unplanned disturbances, are obtained and implemented on-line to save the batch. Also, the available computational time for the optimization is limited as the re-optimized trajectories need to be implemented in real-time on the actual system. In the present study, the OOC of such a system, i.e., bulk polymerization of methyl methacrylate (MMA) in a batch reactor, is carried out in the occurrence of heater malfunction. To solve the underlying multi-objective problem, a multi-objective variant of differential evolution with an improved mutation strategy is developed. The developed algorithm shows faster convergence with respect to other compared algorithms for a large number of benchmark problems. Finally, this algorithm is used to find the optimal temperature trajectories and the OOC with these trajectories found to be successfully countering the effect of heater malfunction.
MPEC 2024-E16 : 2024 EE
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 EE

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
The impact of anthracyclines in intermediate and high-risk HER2-negative early breast cancer : a pooled analysis of the randomised clinical trials PlanB and SUCCESS C
Creators: name: De Gregorio, Amelie
name: Janni, Wolfgang
name: Friedl, Thomas W. P.
name: Nitz, Ulrike
name: Rack, Brigitte
name: Schneeweiss, Andreas
name: Kates, Ronald
name: Fehm, Tanja
name: Kreipe, Hans
name: Christgen, Matthias
name: Kümmel, Sherko
name: Trapp, Elisabeth
name: Würstlein, Rachel
name: Hartkopf, Andreas
name: Clemens, Michael
name: Reimer, Toralf
name: Häberle, Lothar
name: Fasching, Peter A.
name: Gluz, Oleg
name: Harbeck, Nadia
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: DDC 610 / Medicine & health
subject: Breast; Cancer
subject: Breast neoplasms
subject: Randomized controlled trial

description: Background Anthracycline/cyclophosphamide-taxane-containing chemotherapy (AC-T) is the standard of care in the adjuvant treatment of HER2-negative early breast cancer (EBC), but recent studies suggest omission of anthracyclines for reduced toxicity without compromising efficacy. Methods Based on individual patient data (n = 5924) pooled from the randomised Phase III trials PlanB and SUCCESS C, we compared disease-free survival (DFS) and overall survival (OS) between intermediate to high-risk HER2-negative EBC-patients treated with either six cycles of docetaxel/cyclophosphamide (TC6) or an AC-T regime using univariable and adjusted multivariable Cox regression models. Results AC-T conferred no significant DFS or OS advantage in univariable (DFS: hazard ratio (HR) for TC vs. AT 1.05, 95% confidence interval (CI): 0.89–1.24, P = 0.57; OS: HR 1.00, 95% CI: 0.80–1.26, P = 1.00) and adjusted multivariable analysis (DFS: HR 1.01, 95% CI: 0.86–1.19, P = 0.91; OS: HR 0.97, 95% CI: 0.77–1.22, P = 0.79). Patients receiving TC6 had significantly fewer grade 3–4 adverse events. Exploratory subgroup analysis showed that AC-T was associated with significantly better DFS and OS in pN2/3 patients, specifically in those with lobular histology. Conclusion For most patients with HER2-negative EBC, AC-T is not associated with a survival benefit compared to TC6. However, patients with lobular pN2/pN3 tumours seem to benefit from anthracycline-containing chemotherapy.
A Radio Carbon Date from Johnson's Plain, Cumbria.
Creators: name: Woolliscroft, David J
name: Swain, S A M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 92, 274-275
description: Radiocarbon dating of charcoal from the site of a probable Roman signal tower unfortunately produced an improbable Neolithic date, indicating it was in fact re-deposited material.
Genetic alterations in Thai adult patients with acute myeloid leukemia and myelodysplastic syndrome : excess blasts detected by next-generation sequencing technique
Creators: name: Owattanapanich, Weerapat
name: Herzig, Julia
name: Jahn, Nikolaus
name: Panina, Ekaterina
name: Ruchutrakool, Theera
name: Kungwankiattichai, Smith
name: Issaragrisil, Surapol
name: Döhner, Hartmut
name: Döhner, Konstanze
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Acute myeloid leukemia
subject: Genetic
subject: Molecular
subject: Next-generation sequencing
subject: DDC 610 / Medicine & health
subject: Leukemia, Myeloid, Acute
subject: Leukemia, Myeloid, Acute; Genetics
subject: High-throughput nucleotide sequencing
subject: Thailand
subject: Akute myeloische Leukämie
subject: Genanalyse

description: Several molecular aberrations affect the prognosis of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with excess blasts (EB). This study aimed to determine the incidence and clinical impact of molecular genetic aberrations in Thai patients with AML and MDS-EB, detected by the next-generation sequencing (NGS) technique. This prospective, observational study was conducted between 2018 and 2020 on newly diagnosed Thai AML or MDS-EB patients aged above 15 years. NGS was performed using a custom amplicon-based targeted enrichment assay for 42 genes recurrently mutated in myeloid neoplasms. The molecular results were correlated with baseline patient and disease characteristics as well as outcomes. Forty-nine patients were enrolled in this study. The median age was 56 years (interquartile range [IQR], 44–64), with nearly equal proportions of males and females. The median number of mutations was 3 (IQR, 2–4). The most frequent alterations were FLT3 internal tandem duplications (ITD) (28.6%), DNMT3A (24.5%), and WT1 (22.4%) mutations. FLT3-ITD was more frequent in the de novo AML group than in the MDS/secondary AML group, whereas in the MDS/secondary AML group, ASXL1, ETV6, and SRSF2 mutations were more frequent. Patients aged greater than 65 years and patients with mutated TP53 were more likely to have inferior overall survival from multivariate analysis. FLT3-ITD was the most common mutation among newly diagnosed Thai AML patients. TP53 mutation and advanced age were independent adverse factors for survival outcome. The genetic landscapes of AML patients vary between national populations. Thai Clinical Trials Registry identifier: TCTR20190227003.
Additional file 1 of Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction
Creators: name: Jia, Congzhuo
name: Wu, Wanying
name: Lu, Huan
name: Liu, Jin
name: Chen, Shiqun
name: Liang, Guoxiao
name: Zhou, Yang
name: Yu, Sijia
name: Qiao, Linfang
name: Chen, Jinming
name: Tan, Ning
name: Liu, Yong
name: Chen, Jiyan
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology

description: Supplementary Material 1.
Enclosures at Bracken Rigg, Ullswater.
Creators: name: Richardson, Alan
name: Allan, T M M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 92, 273-274
description: Limited investigation into site revealed by aerial photography suggests the presence of a levelled rampart and further that this may represent a RB fort or native settlement.
The verb–self link : an implicit association test study
Creators: name: Weis, Patrick P.
name: Nikadon, Jon
name: Herbert, Cornelia
name: Formanowicz, Magdalena
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Agency
subject: DDC 150 / Psychology
subject: Language
subject: Self
subject: Sprache
subject: Verb

description: Agency is defined as the ability to assign and pursue goals. Given people’s focus on achieving their own goals, agency has been found to be strongly linked to the self. In two studies (N = 168), we examined whether this self–agency link is visible from a linguistic perspective. As the preferred grammatical category to convey agency is verbs, we hypothesize that, in the Implicit Association Test (IAT), verbs (vs. nouns) would be associated more strongly with the self (vs. others). Our results confirmed this hypothesis. Participants exhibited particularly fast responses when reading self-related stimuli (e.g., “me” or “my”) and verb stimuli (e.g., “deflect” or “contemplate”) both necessitated pressing an identical rather than different response keys in the IAT (d = .25). The finding connects two streams of literature—on the link between agency and verbs and on the link between self and agency—suggesting a triad between self, agency, and verbs. We argue that this verb–self link (1) opens up new perspectives for understanding linguistic expressions of agency and (2) expands our understanding of how word choice impacts socio-cognitive processing.
Additional file 5 of The national economic burden of rare disease in the United States in 2019
Creators: name: Yang, Grace
name: Cintina, Inna
name: Pariser, Anne
name: Oehrlein, Elisabeth
name: Sullivan, Jamie
name: Kennedy, Annie
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 5. Mapping of Indirect & Non-Medical Cost Components to Disease Group (DG). Provides mapping of cost components to rare disease group.
Additional file 1 of CSF GFAP levels in double seronegative neuromyelitis optica spectrum disorder: no evidence of astrocyte damage
Creators: name: Hyun, Jae-Won
name: Kim, Yeseul
name: Kim, Ki Hoon
name: Kim, Su-Hyun
name: Olesen, Mads Nikolaj
name: Asgari, Nasrin
name: Siritho, Sasitorn
name: Paul, Friedemann
name: Kim, Ho Jin
Publisher: name: figshare
Year: 2022
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Supplementary table 1. The titers of AQP4 and MOG antibodies.
Mesolithic habitation sites at St. Bees, Cumberland
Creators: name: Cherry, James
name: Cherry, Peter J
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 73, 47-66
description: NX 9414 etc. Fieldwalking has produced evidence of extensive habitation sites at St Bees and at Tarnflat. Dependence on beach pebble flint had been lessened by exploitation of volcanic tuff, even for microliths. St Bees had a higher proportion of geometrical shapes than, say, Eskmeals; but notched blades and microburins were absent. A few possible Neo-EBA artefacts were found.
Excavations on a Langdale axe chipping site in 1969 and 1970
Creators: name: Clough, T H McK
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 73, 25-46
description: NY 274081. Numerous chipping sites are now known in the Pike of Stickle area; one of these, discovered in 1966 on the slopes of Thunacar Knott, was 14C-dated to early 3rd millennium. Limited excavations have now produced broken roughouts and flakes and another 14C date, this time in mid-3rd millennium. A separate site was clearly occupied only by a "finisher". Taking all the British dates for Group VI axes, the main activity at Langdale is in c 2750-2500 BC, though the full extent is not known. Results of pollen analyses are appended.
Altered apoptosis/autophagy and epigenetic modifications cause the impaired postimplantation octaploid embryonic development in mice
Creators: name: Bao-Jiang Wu
name: Zhao, Li-Xia
name: Zhu, Cheng-Cheng
name: Yang-Lin Chen
name: Meng-Yi Wei
name: Si-Qin Bao
name: Shao-Chen Sun
name: Li, Xi-He
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Polyploids are pervasive in plants and have large impacts on crop breeding, but natural polyploids are rare in animals. Mouse diploid embryos can be induced to become tetraploid by blastomere fusion at the 2-cell stage and tetraploid embryos can develop to the blastocyst stage in vitro. However, there is little information regarding mouse octaploid embryonic development and precise mechanisms contributing to octaploid embryonic developmental limitations are unknown. To investigate the genetic and epigenetic mechanisms underlying octaploid embryonic development, we generated mouse octaploid embryos and evaluated the in vitro/in vivo developmental potential. Here we show that octaploid embryos can develop to the blastocyst stage in vitro, but all fetus impaired immediately after implantation. Our results indicate that cell lineage specification of octaploid embryo was disorganized. Furthermore, these octaploid embryos showed increased apoptosis as well as alterations in epigenetic modifications when compared with diploid embryos. Thus, our cumulative data provide cues for why mouse octaploid embryonic development is limited and its failed postimplantation development.
Additional file 1 of Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
Creators: name: Laferrière, Florent
name: Sabatier, Ludivine
name: Claverol, Stéphane
name: De Giorgi, Francesca
name: Ichas, François
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Additional file 1. Fig. S1. SDS-PAGE and filter-blot of brain homogenate samples and sarkosyl-pelleting fractions. Fig. S2. Drop-blot of total brain homogenate samples and sarkosyl-pelleting fractions. Fig. S3. Development and validation of the in-house α-syn sandwich ELISA procedure. Fig. S4. Correlations of patients’ neuropathology scores with α-syn aggregation measurements. Table S1. Proteomic data summary of brain homogenates and sarkosyl-insoluble fractions. Materials and methods.
Cs(I) and Sr(II) Sorption onto Graphene Oxide
Creators: name: A. Y. Romanchuk
name: A. S. Kuzenkova
name: A. S. Slesarev
name: J. M. Tour
name: S. N. Kalmykov
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This article demonstrates the efficacy of graphene oxide (GO) for Cs(I) and Sr(II) removal from aqueous solutions in the presence of competing cations. The interaction mechanisms of Cs(I) and Sr(II) with GO were studied at varying pHs, ionic strengths, and solution compositions. Thermal treatment was studied as a possible approach to minimize the volume of secondary radioactive waste, and cumulative pre-concentration factors were recorded for both cations.
Two decades of tuberculosis surveillance reveal disease spread, high levels of exposure and mortality and marked variation in disease progression in wild meerkats
Creators: name: Müller-Klein, Nadine
name: Risely, Alice
name: Schmid, Dominik W.
name: Manser, Marta
name: Clutton-Brock, Tim
name: Sommer, Simone
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Individual life-history trajectories
subject: long-term surveillance
subject: meerkats (Suricata suricatta)
subject: wildlife disease
subject: Mycobacterium tuberculosis complex
subject: DDC 590 / Animals (Zoology)
subject: DDC 610 / Medicine & health
subject: South Africa
subject: Tuberculosis
subject: Wildlife diseases
subject: Erdmännchen
subject: Südafrika
subject: Tuberkulose

description: Infections with tuberculosis (TB)-causing agents of the Mycobacterium tuberculosis complex threaten human, livestock and wildlife health globally due to the high capacity to cross trans-species boundaries. Tuberculosis is a cryptic disease characterized by prolonged, sometimes lifelong subclinical infections, complicating disease monitoring. Consequently, our understanding of infection risk, disease progression, and mortality across species affected by TB remains limited. The TB agent Mycobacterium suricattae was first recorded in the late 1990s in a wild population of meerkats inhabiting the Kalahari in South Africa and has since spread considerably, becoming a common cause of meerkat mortality. This offers an opportunity to document the epidemiology of naturally spreading TB in a wild population. Here, we synthesize more than 25 years’ worth of TB reporting and social interaction data across 3420 individuals to track disease spread, and quantify rates of TB social exposure, progression, and mortality. We found that most meerkats had been exposed to the pathogen within eight years of first detection in the study area, with exposure reaching up to 95% of the population. Approximately one quarter of exposed individuals progressed to clinical TB stages, followed by physical deterioration and death within a few months. Since emergence, 11.6% of deaths were attributed to TB, although the true toll of TB-related mortality is likely higher. Lastly, we observed marked variation in disease progression among individuals, suggesting inter-individual differences in both TB susceptibility and resistance. Our results highlight that TB prevalence and mortality could be higher than previously reported, particularly in species or populations with complex social group dynamics. Long-term studies, such as the present one, allow us to assess temporal variation in disease prevalence and progression and quantify exposure, which is rarely measured in wildlife. Long-term studies are highly valuable tools to explore disease emergence and ecology and study host–pathogen co-evolutionary dynamics in general, and its impact on social mammals.
Additional file 1 of Are pre- and early pregnancy lifestyle factors associated with the risk of preterm birth? A secondary cohort analysis of the cluster-randomised GeliS trial
Creators: name: Raab, Roxana
name: Hoffmann, Julia
name: Spies, Monika
name: Geyer, Kristina
name: Meyer, Dorothy
name: Günther, Julia
name: Hauner, Hans
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1 Preterm incidence in intervention and control group. Table S2 Characteristics of eligible and included participants. Table S3 Proportions of spontaneous and iatrogenic preterm births. Table S4 Associations between sociodemographic, health and lifestyle factors and the odds of preterm birth – models including linear covariates. Table S5 Associations between sociodemographic, health and lifestyle factors and the odds of iatrogenic preterm birth – models including categorical covariates. Table S6 Associations between sociodemographic, health and lifestyle factors and the odds of iatrogenic preterm birth – models including linear covariates. Table S7 Associations between sociodemographic, health and lifestyle factors and the odds of spontaneous preterm birth – models including categorical covariates. Table S8 Associations between sociodemographic, health and lifestyle factors and the odds of spontaneous preterm birth – models including linear covariates.
Depressive emotionality moderates the influence of the BDNF Val66Met polymorphism on executive functions and on unconscious semantic priming
Creators: name: Sanwald, Simon
name: Montag, Christian
name: Kiefer, Markus
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Semantic priming
subject: Executive functions
subject: Primary emotions
subject: AUTOMATIC SPREADING ACTIVATION
subject: NEUROTROPHIC FACTOR
subject: ELECTRICAL-STIMULATION
subject: INDIVIDUAL-DIFFERENCES
subject: ATTENTIONAL MODULATION
subject: STROOP INTERFERENCE
subject: WORKING-MEMORY
subject: HIPPOCAMPAL
subject: DDC 150 / Psychology
subject: Depression; Genetics
subject: Brain
subject: Memory, Short-term
subject: Emotions
subject: Personality
subject: Nerve growth factors
subject: Depression
subject: Genetik
subject: Persönlichkeit
subject: Gefühl
subject: Priming
subject: Arbeitsgedächtnis
subject: Brain-derived neurotrophic factor

description: Automatic semantic processing can be assessed using semantic priming paradigms. Individual differences in semantic priming have been associated with differences in executive functions. The brain-derived neurotrophic factor (BDNF) Val66Met (substitution of valine (Val) to methionine (Met) at codon 66) polymorphism has been shown to be associated with executive functions as well as depression. Depression-associated variables such as depressed mood also moderated the relationship between BDNF Val66Met and executive functions in previous work. In this study, we therefore aimed at investigating whether BDNF Val66Met genotype modulates masked and unmasked semantic priming as well as executive functions and whether sadness is a moderator of these associations. We collected data of N = 155 participants measuring reaction times (RTs) as well as error rates (ERs) in masked and unmasked semantic priming paradigms using a lexical decision task. We assessed the primary emotion of SADNESS using the Affective Neuroscience Personality Scale (ANPS) and working memory using digit span forward and backward tasks. Met+ carriers showed reduced RT priming and increased ER priming in the masked priming paradigm. Even though there was no direct association between BDNF Val66Met and executive functions, SADNESS significantly moderated the association between BDNF Val66Met and executive functions as well as masked RT priming. We suggest that Met+ individuals with low depressive tendencies have not only superior EF, but also a faster and more superficial processing style, compared with Val/Val homozygotes. However, in Met+ individuals, cognitive functioning exhibits a greater vulnerability to depressed emotionality compared with Val/Val homozygotes. Our study thus demonstrates how emotional and molecular genetic factors exert an interacting influence on higher-level cognition.
Additional file 1 of An epidemiological investigation of high-risk infants for Respiratory Syncytial Virus infections: a retrospective cohort study
Creators: name: Servadio, Michela
name: Finocchietti, Marco
name: Vassallo, Chiara
name: Cipelli, Riccardo
name: Heiman, Franca
name: Di Lucchio, Giulia
name: Oresta, Bianca
name: Addis, Antonio
name: Belleudi, Valeria
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1.
Are mental disorders associated with recidivism in men convicted of sexual offenses?
Creators: name: Biedermann, Laura
name: Eher, Reinhard
name: Rettenberger, Martin
name: Gaunersdorfer, Kathrin
name: Turner, Daniel
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: actuarial risk assessment
subject: mental disorders
subject: sexual and violent reconviction
subject: sexual offenses
subject: ACTUARIAL RISK-ASSESSMENT
subject: VIOLENT RECIDIVISM
subject: OFFENDERS
subject: METAANALYSIS
subject: MODEL
subject: ASSESSMENTS
subject: NARCISSISM
subject: INTERESTS
subject: PSYCHOSIS
subject: DIAGNOSES
subject: DDC 150 / Psychology

description: Introduction In offending populations, prevalence rates of mental disorders are much higher than in the general population. Nevertheless, it is unclear whether mental disorders can improve the prediction of recidivism beyond actuarial risk assessment tools. Methods The present prospective-longitudinal study was conducted between 2001 and 2021 and included 1066 men convicted of sexual offenses in Austria. All participants were evaluated with actuarial risk assessment tools for the prediction of sexual and violent recidivism and the Structured Clinical Interview for Axis I and Axis II disorders. Sexual and violent reconvictions were assessed. Results Exhibitionism and an exclusive pedophilia showed the strongest correlations with sexual recidivism in the total sample. In the child related offense subsample additionally a narcissistic personality disorder was correlated with sexual recidivism. The strongest correlation with violent recidivism was found for an antisocial and borderline personality disorder. None of the mental disorders could improve the prediction of recidivism beyond actuarial risk assessment tools. Conclusion Common current actuarial risk assessment tools revealed good predictive accuracy in men convicted of sexual offenses. With few exceptions mental disorders were only weakly associated with recidivism, suggesting that there is no direct link between mental disorders and violent and sexual reoffending. Mental disorders should nevertheless be considered in treatment issues.
Head/skull injury potential of empty 0.5-l beer glass bottles vs. 0.33-l Coke bottles
Creators: name: Nentwig, C.
name: Steinhoff, S.
name: Adamec, J.
name: Kunz, S. N.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Glass bottles
subject: Head injury
subject: Assault
subject: Blast with an object
subject: DDC 610 / Medicine & health
subject: Forensic medicine
subject: Craniocerebral trauma
subject: Rechtsmedizin
subject: Kopfverletzung

description: The medical and biomechanical assessment of injuries from blows to the head is a common task in forensic medicine. In the context of a criminal justice process, the injury potential of different striking weapons is important. The article at hand compares the injury potential of assaults with a 0.5-l beer bottle and a 0.33-l Coke bottle, both made of glass. The research team hit 30 used empty 0.5-l beer bottles and 20 used empty 0.33-l Coke bottles manually on an aluminum dummy skull set on a force measuring plate, using acrylic and pork rind as a scalp surrogate. There was no significant difference in fracture threshold and energy transfer between the examined beer and Coke bottles. Both glass bottles are able to cause fractures to the facial bones while cranial bone fractures are primarily not to be expected. Blows with a 0.5-l beer bottle or with a 0.33-l Coke bottle to the head can transfer up to 1.255 N and thus are able to cause severe blunt as well as sharp trauma injuries.
Additional file 1 of GenomicDistributions: fast analysis of genomic intervals with Bioconductor
Creators: name: Kupkova, Kristyna
name: Mosquera, Jose Verdezoto
name: Smith, Jason P.
name: Stolarczyk, Michał
name: Danehy, Tessa L.
name: Lawson, John T.
name: Xue, Bingjie
name: Stubbs, John T.
name: LeRoy, Nathan
name: Sheffield, Nathan C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Contains supplementary methods, supplementary Figs. (S1-S6), supplementary Tables (S1, S3 and S4) and supplementary references.
Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation
Creators: name: Pauwels, Sara
name: Manosij Ghosh
name: Duca, Radu Corneliu
name: Bekaert, Bram
name: Freson, Kathleen
name: Huybrechts, Inge
name: Langie, Sabine A. S.
name: Koppen, Gudrun
name: Devlieger, Roland
name: Lode Godderis
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Maternal nutrition is critically involved in the development and health of the fetus. We evaluated maternal methyl-group donor intake through diet (methionine, betaine, choline, folate) and supplementation (folic acid) before and during pregnancy in relation to global DNA methylation and hydroxymethylation and gene specific (IGF2 DMR, DNMT1, LEP, RXRA) cord blood methylation. A total of 115 mother-infant pairs were enrolled in the MAternal Nutrition and Offspring's Epigenome (MANOE) study. The intake of methyl-group donors was assessed using a food-frequency questionnaire. LC-MS/MS and pyrosequencing were used to measure global and gene specific methylation, respectively. Dietary intake of methyl-groups before and during pregnancy was associated with changes in LEP, DNMT1, and RXRA cord blood methylation. Statistically significant higher cord blood LEP methylation was observed when mothers started folic acid supplementation more than 6 months before conception compared with 3–6 months before conception (34.6 ± 6.3% vs. 30.1 ± 3.6%, P = 0.011, LEP CpG1) or no folic acid used before conception (16.2 ± 4.4% vs. 13.9 ± 3%, P = 0.036 for LEP CpG3 and 24.5 ± 3.5% vs. 22.2 ± 3.5%, P = 0.045 for LEP mean CpG). Taking folic acid supplements during the entire pregnancy resulted in statistically significantly higher cord blood RXRA methylation as compared with stopping supplementation in the second trimester (12.3 ± 1.9% vs. 11.1 ± 2%, P = 0.008 for RXRA mean CpG). To conclude, long-term folic acid use before and during pregnancy was associated with higher LEP and RXRA cord blood methylation, respectively. To date, pregnant women are advised to take a folic acid supplement of 400 µg/day from 4 weeks before until 12 weeks of pregnancy. Our results suggest significant epigenetic modifications when taking a folic acid supplement beyond the current advice.
Analysis of 2D-DIGE
Creators: name: Matyushkina, Daria
Publisher: name: figshare
Year: 2016
Subjects: subject: 60501 Bacteriology
subject: FOS: Biological sciences
subject: 60307 Host-Parasite Interactions
subject: Parasitology
subject: 60109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics)

description: Chicken
Additional file 1 of Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Creators: name: Koestler, Stefan A.
name: Ball, Madeleine L.
name: Muresan, Leila
name: Dinakaran, Vineet
name: White, Robert
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
РОЛЬ ПРОФСОЮЗОВ В ЗАЩИТЕ ТРУДОВЫХ ПРАВ РАБОТНИКОВ
Creators: name: Ажимуратова, Зульфира
Publisher: name: Zenodo
Year: 2024

description: В данном тезисе рассматривается важная роль профсоюзов в защите трудовых прав работников как в историческом, так и в современном контексте. Автор обсуждает исторические корни профсоюзов, их основные функции и деятельность в современном мире. Тезис также подчеркивает вызовы, с которыми сталкиваются профсоюзы в современной экономике, и важность их адаптации к новым условиям для эффективной защиты трудовых прав работников.
Role of the partial charge transfer on the chloride adlayers on Au(100)
Creators: name: Ávila, Milagros
name: Juárez, María F.
name: Santos, Elizabeth
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: chloride adsorption on gold
subject: electrosorption valency
subject: partial charge transfer
subject: work function
subject: DEPENDENCE
subject: STATE
subject: DDC 540 / Chemistry & allied sciences
subject: Dipole moments
subject: Electron work function
subject: Adsorption
subject: Halides
subject: Adsorption
subject: Abhängigkeit

description: Paradigm shift: We have investigated the nature of the bond of 84 different geometrical configurations and 102 single adsorption events for different coverages of adlayers of chloride on Au(100) electrodes. In all the cases the adsorbed chloride is partially charged. The electronic properties of these adlayers are discussed on the basis of the analysis of dipole moments, electronic charge density redistribution, density of electronic states and changes in the work function. We focused on a controversial old issue of the electrochemistry community, partial charge transfer reactions. We chose as paradigmatic example the adlayers of chloride on Au(100) electrodes. In the light of new developments we have investigated the nature of the bond of 84 different geometrical configurations and 102 single adsorption events for different coverages. In all the cases the adsorbed chloride is partially charged. The electronic properties of these adlayers are discussed on the basis of the analysis of dipole moments, electronic charge density redistribution, density of electronic states and changes in the work function.
Differences of the tumour cell glycocalyx affect binding of capsaicin-loaded chitosan nanocapsules
Creators: name: Von Palubitzki, Lydia
name: Wang, Yuanyuan
name: Hoffmann, Stefan
name: Vidal-Y-Sy, Sabine
name: Zobiak, Bernd
name: Failla, Antonio V.
name: Schmage, Petra
name: John, Axel
name: Osorio-Madrazo, Anayancy
name: Bauer, Alexander T.
name: Schneider, Stefan W.
name: Goycoolea, Francisco M.
name: Gorzelanny, Christian
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Biological techniques
subject: Biophysics
subject: Cancer
subject: Cell biology
subject: Nanoscience and technology
subject: Oncology
subject: Urology
subject: DDC 610 / Medicine & health

description: Abstract The glycocalyx regulates the interaction of mammalian cells with extracellular molecules, such as cytokines. However, it is unknown to which extend the glycocalyx of distinct cancer cells control the binding and uptake of nanoparticles. In the present study, exome sequencing data of cancer patients and analysis of distinct melanoma and bladder cancer cell lines suggested differences in cancer cell-exposed glycocalyx components such as heparan sulphate. Our data indicate that glycocalyx differences affected the binding of cationic chitosan nanocapsules (Chi-NCs). The pronounced glycocalyx of bladder cancer cells enhanced the internalisation of nanoencapsulated capsaicin. Consequently, capsaicin induced apoptosis in the cancer cells, but not in the less glycosylated benign urothelial cells. Moreover, we measured counterion condensation on highly negatively charged heparan sulphate chains. Counterion condensation triggered a cooperative binding of Chi-NCs, characterised by a weak binding rate at low Chi-NC doses and a strongly increased binding rate at high Chi-NC concentrations. Our results indicate that the glycocalyx of tumour cells controls the binding and biological activity of nanoparticles. This has to be considered for the design of tumour cell directed nanocarriers to improve the delivery of cytotoxic drugs. Differential nanoparticle binding may also be useful to discriminate tumour cells from healthy cells.
Supplementary figures “The plastid genome of some eustigmatophyte algae harbours a bacteria-derived six-gene cluster for biosynthesis of a novel secondary metabolite” by Tatiana Yurchenko et al
Creators: name: Yurchenko, Tatiana
name: Ševčíková, Tereza
name: Strnad, Hynek
name: Butenko, Anzhelika
name: Eliáš, Marek
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics

description: Supplementary figures S1 to S3
Traba, Robert: Der politische Katholizismus im Ermland. Eine Studie zur deutsch-polnischen Beziehungsgeschichte 1871–1914. Aus dem Polnischen übersetzt von Matthias Barelkowski und Jan Obermeier
Creators: name: Schulte-Umberg, Thomas
Publisher: name: Theologische Revue
Year: 2020

description: Theologische Revue, Bd. 116 (2020): März
Cryo-EM structure and polymorphic maturation of a viral transduction enhancing amyloid fibril
Creators: name: Heerde, Thomas
name: Schütz, Desiree
name: Lin, Yu-Jie
name: Münch, Jan
name: Schmidt, Matthias
name: Fändrich, Marcus
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Cryoelectron microscopy
subject: Protein aggregation
subject: Polymorphic maturation
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 570 / Life sciences
subject: Peptides
subject: Prions
subject: Peptide
subject: Prion

description: Amyloid fibrils have emerged as innovative tools to enhance the transduction efficiency of retroviral vectors in gene therapy strategies. In this study,we used cryo-electron microscopy to analyze the structure of a biotechnologically engineered peptide fibril that enhances retroviral infectivity. Our findings show that the peptide undergoes a time-dependent morphological maturation into polymorphic amyloid fibril structures. The fibrils consist of mated cross-β sheets that interact by the hydrophobic residues of the amphipathic fibrilforming peptide. The now available structural data help to explain the mechanism of retroviral infectivity enhancement, provide insights into the molecular plasticity of amyloid structures and illuminate the thermodynamic basis of their morphological maturation.
Additional file 1 of Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism
Creators: name: Li, Jinying
name: Chen, Yongshao
name: Zha, Dingsheng
name: Wu, Chunhui
name: Li, Xiaofen
name: Yang, Li
name: Cao, Hui
name: Cai, Shexing
name: Cai, Yuebo
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Supplementary Material 1.
Additional file 1 of Situational judgment using ethical reasoning in Saudi undergraduate pharmacy students
Creators: name: Alkhuzaee, Fahad Saleh
name: Ali, Majid
name: Goh, Khang Wen
name: Al-Worafi, Yaser Mohammed
name: Ming, Long Chiau
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Ethical dilemmas developed and validated in the study.
The Slate Quarrying Industry in Westmorland: Part Two. A Field survey of selected sites in Troutbeck and Longsleddale.
Creators: name: David, Rob G
name: Brambles, G W W
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 92, 213-228
description: Presents details of High Quarry, including information on the office building, riving shed and weigh house. Also the small scale eighteenth century Stockdalebank Quarry, along with the quarry at Wrengill, with details of its forge and barracks. Two nineteenth century engravings depicting Wrengill quarry are illustrated as are the power house or workshop structure. There follows an `Appendix: Kentmere Head slate quarries [&] Wrengill and Stockdalebank slate quarries' (225--7) giving some documentary references to the sites.
Sup. Figure 1: Preferential location of S variants of M. abscessus in loner phagosomes within BMDM.; Sup. Figure 2: In vitro growth of the S and R variants of M. abscessus.; Sup. Figure 3: Comparative intracellular growth of the S (A) and R (B) variants in wild type and ΔF508 murine Mф respectively.; Sup. Figure 4: M. abscessus S variant is able to damage the phagosome membrane of THP-1 cells as assessed by FRET.
Creators: name: Anne-Laure Roux
name: Viljoen, Albertus
name: Aïcha Bah
name: Simeone, Roxane
name: Bernut, Audrey
name: Laencina, Laura
name: Deramaudt, Therese
name: Rottman, Martin
name: Jean-Louis Gaillard
name: Majlessi, Laleh
name: Brosch, Roland
name: Girard-Misguich, Fabienne
name: Vergne, Isabelle
name: Chastellier, Chantal De
name: Kremer, Laurent
name: Jean-Louis Herrmann
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Mycobacterium abscessus is a pathogenic, rapidly growing mycobacterium responsible for pulmonary and cutaneous infections in immunocompetent patients and in patients with Mendelian disorders, such as cystic fibrosis (CF). Mycobacterium abscessus is known to transition from a smooth (S) morphotype with cell surface-associated glycopeptidolipids (GPL) to a rough (R) morphotype lacking GPL. Herein, we show that M. abscessus S and R variants are able to grow inside macrophages and are present in morphologically distinct phagosomes. The S forms are found mostly as single bacteria within phagosomes characterized by a tightly apposed phagosomal membrane and the presence of an electron translucent zone (ETZ) surrounding the bacilli. By contrast, infection with the R form leads to phagosomes often containing more than two bacilli, surrounded by a loose phagosomal membrane and lacking the ETZ. In contrast with the R variant, the S variant is capable of restricting intraphagosomal acidification and induces less apoptosis and autophagy. Importantly, the membrane of phagosomes enclosing the S forms showed signs of alteration such as breaks or partial degradation. Although not frequently encountered, these events suggest that the S form is capable of provoking phagosome-cytosol communications. In conclusion, M. abscessus S exhibits traits inside macrophages that are reminiscent of slow-growing mycobacterial species.
Subtype specific expression and survival prediction of pivotal lncRNAs in muscle invasive bladder cancer
Creators: name: Rinaldetti, Sebastien
name: Worst, Thomas Stefan
name: Rempel, Eugen
name: Kriegmair, Maximilian C.
name: Hartmann, Arndt
name: Porubsky, Stefan
name: Bolenz, Christian
name: Erben, Philipp
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Cancer
subject: Urological cancer
subject: LONG NONCODING RNA
subject: MOLECULAR TAXONOMY
subject: PROSTATE
subject: MARKER
subject: IDENTIFICATION
subject: PROLIFERATION
subject: ASSOCIATION
subject: CARCINOMA
subject: GAS5
subject: GENE
subject: DDC 610 / Medicine & health

description: Abstract Comprehensive transcriptome expression analyses of bladder cancer revealed distinct lncRNA clusters with differential molecular and clinical characteristics. In this study, pivotal lncRNAs were assessed for their impact on survival and their differential expression between the molecular bladder cancer subtypes. FFPE samples from chemotherapy-naïve patients with muscle invasive bladder cancer (MIBC) were analyzed on the Nanostring nCounter platform for absolute quantification. An established 36-gene panel was used for molecular subtype classification into basal, luminal and infiltrated MIBC. In a second step, 14 pivotal lncRNAs were assessed for their molecular subtype attribution, and their predictive value in disease-specific survival. In silico validation was performed on a total of 487 MIBC patients (MDA, TGCA and Chungbuk cohort). Several pivotal lncRNAs showed a distinct molecular subtype attribution: e.g. MALAT1 showed a downregulation in the basal subtype (p = 0.009), TUG1 and CBR3AS1 showed an upregulation in the luminal subtype (p ≤ 0.001). High transcript levels of SNHG16, CBR3AS1 and H19 appeared to be predictive for a shorter disease-specific survival. Patients overexpressing putative oncogenes MALAT1 and TUG1 in MIBC tissue presented prolonged survival, suggesting tumor suppressive effects of both lncRNAs. The Nanostring nCounter proved to be a valid platform for the quantification of low-abundance transcripts including lncRNAs.
Additional file 1 of Changes in disease burden and global inequalities in bladder, kidney and prostate cancers from 1990 to 2019: a comparative analysis based on the global burden of disease study 2019
Creators: name: Huang, Qiao
name: Yang, Jun
name: Liu, Guo-Xiong
name: Zi, Hao
name: Tang, Shi-Di
name: Jia, Hai-Chang
name: Li, Wei
name: Xu, Xiao-Feng
name: Zeng, Xian-Tao
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1.
Electrophysiological correlates of response time outliers: Outlier related potentials
Creators: name: Berger, Alexander
name: Kiefer, Markus
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: CNV
subject: EEG
subject: ERP
subject: outlier
subject: P3
subject: response time
subject: CONTINGENT NEGATIVE-VARIATION
subject: LATE POSITIVE COMPLEX
subject: ATTENTIONAL MODULATION
subject: P3 LATENCY
subject: COMPONENTS
subject: AMPLITUDE
subject: STIMULUS
subject: UTILITY
subject: SIGN
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health

description: In response time (RT) research, RTs which largely deviate from the RT distribution are considered “outliers”. Outliers are typically excluded from RT analysis building upon the implicit assumption that cognitive processing is distorted in outlier trials. The present study aims to test this assumption by comparing cognitive processing indexed by event-related potentials (ERP) of trials with outliers and valid trials in two different tasks. To this end, we compared stimulus- and response-locked ERPs for outliers identified by nine different methods with valid trials, using cluster-based permutation tests. Consistently across outlier exclusion methods and tasks, the late positive complex (P3) associated with response-related processes was reduced in outliers. Analyses of response-locked ERPs related this P3 attenuation to a slower and temporally more extended increase of the P3, possibly indexing reduced evidence accumulation speed in outliers. P3 peak amplitude in response-locked ERPs was similar between outliers and valid trials, suggesting that the absolute amount of evidence required for a response remained comparable. Furthermore, in addition to these more general ERP correlates of outliers, the contingent negative variation (CNV) ERP component was reduced in outliers as a function of preparatory demands of the task. Hence, electrophysiological correlates, and thus cognitive processing, are altered in outliers compared to valid trials. In order to avoid distortion of observed ERP differences between conditions, the RT outlier distribution should be considered for the analysis of ERPs in combined ERP and RT studies.