cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Bony Sacral Volume after Sacro-Iliac Screw Fixation of Pelvic Fractures Is Dependent on Reduction of the Anterior Pelvic Ring
Creators: name: Baumann, Florian
name: Pagano, Stefano
name: Alt, Volker
name: Freigang, Viola
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: pelvic fracture; sacral anatomy; sacro-ilical screw fixation; volumetric measurement
subject: 610 Medizin

description: Pelvic ring injuries are uncommon but serious injuries. Percutaneous sacro-iliac screw fixation (SSF) is the standard treatment for posterior stabilization of pelvic fractures. Compression forces of the SSF might cause deformity of the sacrum and the pelvic ring. The aim of this radio-volumetric study is to evaluate the morphometry of the sacrum and pelvic ring in SSF for posterior pelvic fractures. (1) Methods: We conducted a radio-volumetric study measuring the bony sacral volume before and after SSF for a pelvic fracture based on a three-dimensional reconstruction of the pre- and postoperative computed tomography scan of 19 patients with a C-type pelvic fracture. In addition to the bony sacral volume, we assessed the pelvic deformity and the load bearing axis. We compared the results of patients without anterior stabilization (Group A) to patients who had additional ORIF of the anterior pelvic ring. (2) Results: Median age of the patients was 41.2 years (±17.8). All patients received percutaneous SSF with partially threaded 7.3mm screws. The sacral volume decreased from 202.9 to 194.3 cm3 in group A (non-operative treatment anterior, n = 10) and an increase of sacral volume from 229.8 to 250.4 cm3 in group B (anterior ORIF; n = 9). Evaluation of the pelvic deformity also reflected this trend by a decrease of the ipsilateral load-bearing angle in group A (37.0° to 36.4°) and an increase of this angle in group B (36.3 to 39.9°). (3) Conclusions: Bony sacral volume and pelvic deformity after sacro-iliac screw fixation in pelvic fractures depend on treatment of the anterior pelvic ring. Reduction and fixation of the anterior fracture shows an increase of the bony sacral volume and the load bearing angle leading to a closer to normal reconstruction of the pelvic anatomy.
Senge, Stephan Reimund: Von Birke und Wind ; Wider die Fürchtemaschine
Creators: name: Hugoth, Matthias
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Seriousness is the Standard of both Itself and the Fatuous
Creators: name: Regina, Luciana
Publisher: name: Spazio Filosofico
Year: 2016

description: The intuition from which we start is that the conceptual crisis affecting seriousness is one of the major features that characterize our time. In this context, by “conceptual crisis” one should understand a condition of extreme vagueness affecting a concept whose task should be instead that of accurately educating individuals to the kind of respect due to reality in all its specific manifestations.


One could say of seriousness what Spinoza thought of truth, namely, that seriousness is the standard of both itself and the fatuous. What seriousness discloses in its rare epiphanies is its a posteriori unequivocality. Combining this element with its irrelevance in everyday affairs creates a philosophical problem and several social issues.
description: Spazio Filosofico, 18. Serietà
Ctenoplusia fracta Walker 1858
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia fracta

description: Ctenoplusia fracta (Walker, 1858)
(Fig. 28)
Material examined. Oromia Region, Wonchi Crater. 3300 m. V.2009. Leg. Kravchenko V.; Oromia Region, Shenen. 2500 m. V.2009. Leg. Kravchenko V.
Literature. Behounek & Ronkay 1989; Behounek et al. 2010; Dufay 1970; Dufay & Laporte 1977; Hacker 1999; Hacker et al. 2001; Hacker et al. 1999; Kravchenko et al. 2007; Paulian & Viette 1955; Pinhey 1975; Ronkay 1987; Rougeot 1983; Wiltshire 1990.
General distribution pattern. Throughout tropical and subtropical Africa: Cameroon, Democratic Republic of Congo, Ethiopia, Kenya, Madagascar, Malawi, Mozambique, Nigeria, Senegal, Somalia, South Africa, Tanzania, Uganda and Zimbabwe. In Palearctic region found in Oman, Yemen and Saudi Arabia.
Distribution in Ethiopia. Everywhere except highlands above 3.000 m and deserts. Common.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on pages 242-243, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Brucepattersonius igniventris Hershkovitz 1998
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius igniventris

description: Brucepattersonius igniventris Hershkovitz 1998
Brucepattersonius igniventris Hershkovitz 1998, Bonn. Zool. Beitr., Vol. 47: 232.
Type Locality: Brazil, São Paulo State, Iporanga (Petar) State Park, 200 m; 24º35′S, 48º35′W.
Vernacular Names: Red-bellied Akodont.
Distribution: Known only from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1105, DOI: 10.5281/zenodo.7316535
Grom, Bernhard: Religionspädagogische Psychologie des Kleinkind-, Schul- und Jugendalters
Creators: name: Jockwig, Klemens
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Simultaneous Inhibition of Mcl-1 and Bcl-2 Induces Synergistic Cell Death in Hepatocellular Carcinoma
Creators: name: Michalski, Marlen
name: Bauer, Magdalena
name: Walz, Franziska
name: Tümen, Deniz
name: Heumann, Philipp
name: Stöckert, Petra Diana
name: Gunckel, Manuela
name: Kunst, Claudia
name: Kandulski, Arne
name: Schmid, Stephan
name: Müller, Martina
name: Gülow, Karsten
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: hepatocellular carcinoma (HCC); apoptosis; BH3-mimetics; ABT-199/venetoclax; MIK665/S64315
subject: 610 Medizin

description: Despite the recent approval of new therapies, the prognosis for patients with hepatocellular carcinoma (HCC) remains poor. There is a clinical need for new highly effective therapeutic options. Here, we present a combined application of BH3-mimetics as a potential new treatment option for HCC. BH3-mimetics inhibit anti-apoptotic proteins of the BCL-2 family and, thus, trigger the intrinsic apoptosis pathway. Anti-apoptotic BCL-2 proteins such as Bcl-2 and Mcl-1 are frequently overexpressed in HCC. Therefore, we analyzed the efficacy of the two BH3-mimetics ABT-199 (Bcl-2 inhibitor) and MIK665 (Mcl-1 inhibitor) in HCC cell lines with differential expression levels of endogenous Bcl-2 and Mcl-1. While administration of one BH3-mimetic alone did not substantially trigger cell death, the combination of two inhibitors enhanced induction of the intrinsic apoptosis pathway. Both drugs acted synergistically, highlighting the effectivity of this specific BH3-mimetic combination, particularly in HCC cell lines. These results indicate the potential of combining inhibitors of the BCL-2 family as new therapeutic options in HCC.
Brucepattersonius iheringi
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius iheringi

description: Brucepattersonius iheringi (Thomas 1896)
[Oxymycterus] iheringi Thomas 1896, Ann. Mag. Nat. Hist., ser. 6, 18: 308.
Type Locality: Brazil, Rio Grande do Sul State, Rio dos Linos, Taquara do Mundo Novo.
Vernacular Names: Ihering's Akodont.
Distribution: NE Argentina (Misiones) and SE Brazil.
Conservation: IUCN – Lower Risk (lc) as Oxymycterus iheringi.
Discussion: A distinctive species of varied generic associations—included in Microxus or Akodon (e.g., Avila-Pires, 1994; Cabrera, 1961; Ellerman, 1941; Gyldenstolpe, 1932; Moojen, 1952); reallocated to Oxymycterus by Massoia (1963 b) and thereafter classified (Corbet and Hill, 1991; Honacki et al., 1982; Musser and Carleton, 1993); recently assigned to the new genus Brucepattersonius by Hershkovitz (1998), an allocation seconded by Bonvicino et al. (1998 b). Morphological recognition amplified by Massoia and Fornes (1969).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1105, DOI: 10.5281/zenodo.7316535
No Success without Effort: Follow-Up at Six Years after Implementing a Benchmarking and Feedback Concept for Postoperative Pain after Total Hip Arthroplasty
Creators: name: Reinhard, Jan
name: Pulido, Loreto C.
name: Schindler, Melanie
name: Schraag, Amadeus Dominik
name: Greimel, Felix
name: Grifka, Joachim
name: Benditz, Achim
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: postoperative pain management; benchmarking; total hip arthroplasty (THA); pain management concept; multidisciplinary; QUIPS
subject: 610 Medizin

description: Background: Total hip arthroplasty (THA) is still ranked among the operations with the highest postoperative pain scores. Uncontrolled postsurgical pain leads to prolongated hospital stays, causes more frequent adverse reactions and can induce chronical pain syndromes. In 2014, we implemented a standardized, multidisciplinary pain management concept with continuous benchmarking at our tertiary referral center by using the “Quality Improvement in Postoperative Pain Management” (QUIPS) program with excellent results over a period of two years. The initial study ended in 2016 and we aimed to evaluate if it was possible to obtain the excellent short-term results over a period of six years without any extra effort within the daily clinical routine. Materials and Methods: In a retrospective study design, we compared postoperative pain, side effects and functional outcome after primary THA for 2015 and 2021, using validated questionnaires from the QUIPS project. In contrast to the implementation of the pain management concept in 2014, the weekly meetings of the multidisciplinary health care team and special education for nurses were stopped in 2021. Data assessment was performed by an independent pain nurse who was not involved in pain management. Results: Altogether, 491 patients received primary THA in 2015 and 2021 at our tertiary referral center. Collected data revealed significantly worse maximum and activity-related pain (both p < 0.001) in combination with significantly higher opioid consumption in comparison to implementation in 2015. Though the patients reported to be less involved in pain management (p < 0.001), the worse pain scores were not reflected by patient satisfaction which remained high. While the participation rate in this benchmarking program dropped, we still fell behind in terms of maximum and activity-related pain in comparison to 24 clinics. Conclusion: Significantly worse pain scores in combination with higher opioid usage and a lower hospital participation rate resemble a reduced awareness in postoperative pain management. The significantly lower patient participation in pain management is in line with the worse pain scores and indirectly highlights the need for special education in pain management. The fact patient satisfaction appeared to remain high and did not differ significantly from 2015, as well as the fact we still achieved an acceptable ranking in comparison to other clinics, highlight the value of the implemented multidisciplinary pain management concept.
Study on P.Mich. VII 460 inv. 5756 recto.
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 3
description: Time-table for a possible re-edition, photo, transcription, variants and drawings of the alphabet.
description: Source: 4MAR_21_3.2-15-2-12
description: created: n. d.
Conexus Deliverable D1.1 Communication Strategy & Action Plan Confidential Restricted
Creators: name: Porter, Jonathan
Publisher: name: Horizon 2020 CONEXUS project
Year: 2022

description: This document defines the Conexus project’s approach to communications to achieve positive impact. The communications activity underpins dissemination and exploitation ensuring these activities are closely intertwined. It focuses on: (1) promoting Conexus and its results beyond the project’s own community, reaching out to wider society; and (2) communicating the work of Conexus ways that are understood by non-specialists.
Influence of Laparoscopic Surgery on Cellular Immunity in Colorectal Cancer: A Systematic Review and Meta-Analysis
Creators: name: Bohne, Annika
name: Grundler, Elena
name: Knüttel, Helge
name: Fürst, Alois
name: Völkel, Vinzenz
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: laparoscopy; open surgery; surgical stress response; cellular immunity; natural killer cells; lymphocytes; leukocytes; colon cancer; rectal cancer
subject: 610 Medizin

description: Colorectal cancer (CRC) is the third most common cancer worldwide. The main treatment options are laparoscopic (LS) and open surgery (OS), which might differ in their impact on the cellular immunity so indispensable for anti-infectious and antitumor defense. MEDLINE, Embase, Web of Science (SCI-EXPANDED), the Cochrane Library, Google Scholar, ClinicalTrials.gov, and ICTRP (WHO) were systematically searched for randomized controlled trials (RCTs) comparing cellular immunity in CRC patients of any stage between minimally invasive and open surgical resections. A random effects-weighted inverse variance meta-analysis was performed for cell counts of natural killer (NK) cells, white blood cells (WBCs), lymphocytes, CD4+ T cells, and the CD4+/CD8+ ratio. The RoB2 tool was used to assess the risk of bias. The meta-analysis was prospectively registered in PROSPERO (CRD42021264324). A total of 14 trials including 974 participants were assessed. The LS groups showed more favorable outcomes in eight trials, with lower inflammation and less immunosuppression as indicated by higher innate and adaptive cell counts, higher NK cell activity, and higher HLA-DR expression rates compared to OS, with only one study reporting lower WBCs after OS. The meta-analysis yielded significantly higher NK cell counts at postoperative day (POD)4 (weighted mean difference (WMD) 30.80 cells/µL [19.68; 41.92], p < 0.00001) and POD6–8 (WMD 45.08 cells/µL [35.95; 54.21], p < 0.00001). Although further research is required, LS is possibly associated with less suppression of cellular immunity and lower inflammation, indicating better preservation of cellular immunity.
Ctenoplusia scoteina Dufay 1972
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia scoteina

description: * Ctenoplusia scoteina Dufay, 1972
(Fig.s 29, 62, 63)
Material examined. Bako Gazer woreda, Mago National Park, 600 m, VIII.2011. Leg. Kravchenko V. Literature. Dufay 1972.
General distribution pattern. In tropical Africa: Kenya, Uganda and Zimbabwe. Distribution in Ethiopia. Southern Ethiopia (Omo region). Rare.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 243, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
title: Activité du port de Saint-Malo – 1685 – Levant
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits manufacturés
subject: produits combustibles

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1685 avec le port "Levant"
description: Marchandises arrivées à Saint-Malo : savon ; huile
description: Catégories de marchandises arrivées à Saint-Malo : produits manufacturés ; produits combustibles
description: Coverage: Grand commerce
description: Bibliographic citation: PERSON, Marie-Claire. Le Commerce maritime de Saint-Malo en 1684-1685. DES : Histoire : Rennes, 1962 (Bibliothèque François-Lebrun - Rennes 2, MH 1002)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
title:  Investigation of an Alternative Technique for Measuring Turbulence in the Upper Atmosphere
Creators: name: Leonard, Charles Patrick
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1997

description:
The capability of the Global Positioning System (GPS) as a tool for measuring turbulence in the upper atmosphere is presented. By studying experimental ground and flight test data, a methodology for extracting macroscale turbulence data from in situ measurements was developed.

A description of the GPS using a single nonprecision receiver is followed by data from ground and flight testing. Ground testing focused on determining the smallest turbulent scales discernible by the GPS receiver. Testing was also undertaken to compare turbulence data from the GPS with that of a simultaneously operating constant-temperature hot-wire anemometer, the conventional tool for making turbulence measurements. A zero-pressure balloon launched from NASA Wallops Island provided the platform for stratospheric flight testing. The correlation between radar and GPS data was investigated over the ascent portion of the flight. Due to the limitations of a single non-precision receiver in absolute positioning, a method employing relative differential positioning (and therefore differential velocities) is proposed to capture turbulence data.
Brucepattersonius misionensis Mares and Braun 2000
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius misionensis

description: Brucepattersonius misionensis Mares and Braun 2000
Brucepattersonius misionensis Mares and Braun 2000, Occas. Pap. Sam Noble Oklahoma Mus. Nat. Hist., 9: 7.
Type Locality: Argentina, Misiones Prov., Guaraní Dept., ca. 2 km W Parque Provincial Moconá, junction of Hwy 21 and Arroyo Oveja Negra.
Vernacular Names: Misiones Akodont.
Distribution: Known only from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1105, DOI: 10.5281/zenodo.7316535
Serious Philosophy
Creators: name: Haack, Susan
Publisher: name: Spazio Filosofico
Year: 2016

description: What is serious philosophy? What does it demand of us? And is it true, as some suppose, that a philosopher can’t be serious about his work unless he is solemn and humorless? Calling on ideas from C.S. Peirce, Haack argues first that philosophy is a serious form of inquiry, requiring real commitment and real intellectual effort, and then that playfulness and humor may actually be of help in such inquiry, while solemnity and self-importance will, for sure, impede it .“The serious philosopher,” she concludes “must indeed work in earnest – but not in grim earnest.”
description: Spazio Filosofico, 18. Serietà
Brucepattersonius paradisus Mares and Braun 2000
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius paradisus

description: Brucepattersonius paradisus Mares and Braun 2000
Brucepattersonius paradisus Mares and Braun 2000, Occas. Pap. Sam Noble Oklahoma Mus. Nat. Hist., 9: 3.
Type Locality: Argentina, Misiones Prov., Guaraní Dept., junction of Hwy 2 and Arroyo Paraíso, 197 m.
Vernacular Names: Arroyo of Paradise Akodont.
Distribution: Known only from the type locality.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1105, DOI: 10.5281/zenodo.7316535
Ctenoplusia asteia Dufay 1972
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia asteia

description: * Ctenoplusia asteia Dufay, 1972
(Fig. 30)
Material examined. Bako Gazer woreda, Mago National Park, 600 m. VIII.2011. Leg. Kravchenko V. Literature. Dufay 1972.
General distribution pattern. In tropical Africa: Democratic Republic of Congo, Kenya and Uganda. Distribution in Ethiopia. Southern Ethiopia (Omo region). Rare.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 243, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression in the Elderly: A Retrospective Natural Analysis
Creators: name: Almheiri, Eisa
name: Alhelali, Abdullah
name: Abdelnaim, Mohamed A.
name: Weber, Franziska C.
name: Langguth, Berthold
name: Schecklmann, Martin
name: Hebel, Tobias
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: repetitive transcranial magnetic stimulation; geriatric depression; brain stimulation
subject: 610 Medizin

description: Introduction: Depression in the elderly is an understudied condition. Psychopharmacological and psychotherapeutic approaches suffer from specific difficulties with this patient group. Brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) offer a therapeutic alternative. rTMS remains understudied in this age group when compared with younger patients. Methods: A cohort of 505 patients with depression was analyzed in retrospect concerning their response to rTMS treatment. A total of 15.5% were 60 years old or older, defined as the elderly group of depressed patients. The majority of these were treated with high-frequency protocols over the left dorsolateral prefrontal cortex (DLPFC). For group comparisons, we used Student t-tests or chi-square-tests, depending on the scales of measurement. As measures for effect size, we used Cohen’s d for the relative and absolute change in the HDRS total score. Results: Groups did not differ significantly with respect to baseline depression severity or treatment parameters. In the group of elderly patients, a higher number of females were present. Groups did not differ significantly with respect to treatment efficacy, as indicated by the absolute and relative changes in the HDRS-21 sum score. Elderly patients tended to take higher numbers of mood stabilizers. Elderly patients showed a significantly superior reduction for the item “appetite” and a superior reduction tending towards significance for the item “work and interests”. Conclusions: Antidepressant rTMS treatment showed comparable efficacy for patients above 60 years to that in younger patients. Differences between the age groups concerning amelioration of distinct HDRS single items deserve further investigation.
Scaffold-Based (Matrigel™) 3D Culture Technique of Glioblastoma Recovers a Patient-like Immunosuppressive Phenotype
Creators: name: Braun, Frank K.
name: Rothhammer-Hampl, Tanja
name: Lorenz, Julia
name: Pohl, Sandra
name: Menevse, Ayse-Nur
name: Vollmann-Zwerenz, Arabel
name: Bumes, Elisabeth
name: Büttner, Maren
name: Zoubaa, Saida
name: Proescholdt, Martin
name: Schmidt, Nils O.
name: Hau, Peter
name: Beckhove, Philipp
name: Winner, Beate
name: Riemenschneider, Markus J.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: brain cancer; tumor organoids; GBM; next-generation sequencing; single-cell RNA sequencing
subject: 610 Medizin

description: Conventional 2D cultures are commonly used in cancer research though they come with limitations such as the lack of microenvironment or reduced cell heterogeneity. In this study, we investigated in what respect a scaffold-based (Matrigel™) 3D culture technique can ameliorate the limitations of 2D cultures. NGS-based bulk and single-cell sequencing of matched pairs of 2D and 3D models showed an altered transcription of key immune regulatory genes in around 36% of 3D models, indicating the reoccurrence of an immune suppressive phenotype. Changes included the presentation of different HLA surface molecules as well as cellular stressors. We also investigated the 3D tumor organoids in a co-culture setting with tumor-infiltrating lymphocytes (TILs). Of note, lymphocyte-mediated cell killing appeared less effective in clearing 3D models than their 2D counterparts. IFN-γ release, as well as live cell staining and proliferation analysis, pointed toward an elevated resistance of 3D models. In conclusion, we found that the scaffold-based (Matrigel™) 3D culture technique affects the transcriptional profile in a subset of GBM models. Thus, these models allow for depicting clinically relevant aspects of tumor-immune interaction, with the potential to explore immunotherapeutic approaches in an easily accessible in vitro system.
Risk Factors for the In-Hospital Mortality in Pyogenic Vertebral Osteomyelitis: A Cross-Sectional Study on 9753 Patients
Creators: name: Ziarko, Tomasz Piotr
name: Walter, Nike
name: Schindler, Melanie
name: Alt, Volker
name: Rupp, Markus
name: Lang, Siegmund
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: pyogenic vertebral osteomyelitis; mortality; risk-factors
subject: 610 Medizin

description: Background: Pyogenic vertebral osteomyelitis represents a clinical challenge associated with significant morbidity and mortality. The aim of this study was to analyze potential risk factors for the in-hospital mortality of vertebral osteomyelitis (VO) patients. Methods: Based on the International Classification of Diseases, 10th Revision (ICD-10) codes for VO (“M46.2-”, “M46.3-”, and “M46.4-”) data for total case numbers, secondary diagnoses, and numbers of in-hospital deaths were extracted from the Institute for the Hospital Remuneration System (InEK GmbH). Odds ratios (OR) for death were calculated for several secondary diseases and factors of interest. Results: Despite age, certain comorbidities were found to be strongly associated with increased mortality risk: Heart failure (OR = 2.80; 95% CI 2.45 to 3.20; p < 0.01), chronic kidney disease (OR = 1.83; 95% CI 1.57 to 2.13; p < 0.01), and diabetes with complications (OR = 1.86; 95% CI 1.46 to 2.38; p < 0.01). Among the complications, acute liver failure showed the highest risk for in-hospital mortality (OR = 42.41; 95% CI 23.47 to 76.62; p < 0.01). Additionally, stage III kidney failure (OR = 9.81; 95% CI 7.96 to 12.08; p < 0.01), sepsis (OR = 5.94; 95% CI 5.02 to 7.03; p < 0.01), acute respiratory failure (OR = 5.31; 95% CI 4.61 to 6.12; p < 0.01), and systemic inflammatory response syndrome (SIRS) (OR = 5.19; 95% CI 3.69 to 5.19; p < 0.01) were associated with in-hospital mortality. When analyzing the influence of pathogens, documented infection with Pseudomonas aeruginosa had the highest risk for mortality (OR = 2.74; 95% CI 2.07 to 3.63; p < 0.01), followed by Streptococci, Escherichia coli, and Staphylococcus aureus infections. Conclusions: An early assessment of individual patient risk factors may be beneficial in the care and treatment of VO to help reduce the risks of mortality. These findings emphasize the importance of closely monitoring VO patients with chronic organ diseases, early detection and treatment of sepsis, and tailored empirical antibiotic therapy. The identification of specific pathogens and antibiotic susceptibility testing should be prioritized to improve patient outcomes in this high-risk population.
Brucepattersonius soricinus Hershkovitz 1998
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Brucepattersonius
Brucepattersonius soricinus

description: Brucepattersonius soricinus Hershkovitz 1998
Brucepattersonius soricinus Hershkovitz 1998, Bonn. Zool. Beitr., Vol. 47: 232.
Type Locality: Brazil, São Paulo State, Ribeirão Fundo, 30 m; 24º15′S, 47º45′W.
Vernacular Names: Soricine Akodont.
Distribution: Known only from several localities in São Paulo, SE Brazil.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1105, DOI: 10.5281/zenodo.7316535
Ctenoplusia camptogramma Hampson 1910
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia camptogramma

description: Ctenoplusia camptogramma (Hampson, 1910)
(Fig. 31)
Material examined. Bako Gazer woreda, Mago National Park, 600 m. VIII.2011. Leg. Kravchenko V. Literature. Berio et al. 1984; Hampson 1913.
General distribution pattern. In tropical Africa: Ethiopia, Kenya. Distribution in Ethiopia. Southern Ethiopia (Omo region). Rare. In Bale Mts on elevations over 2300 m, common.
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 243, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
Dorsetensia Buckman 1892
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ammonoidea
Sonniniidae
Dorsetensia

description: Dorsetensia? sp. [M]
(Fig. 14T)
MATERIAL EXAMINED. — JAC22.57.3.
MEASUREMENTS. — See Table 27.
DESCRIPTION
Moderately evolute, whorl section compressed subrectangular with a low umbilical wall that almost matches the rounded umbilical edge. The flanks are gently convex and the ventral area is weakly tabulated with a moderately developed keel. The ribs, arising near the umbilical edge, somewhat irregular in thickness, are mainly simple but some tend to join in pairs near their base. Radial or only barely sinuous, they bend forward at the ventral edge. The ribbing weakens but does not disappear in the BC. The suture is not preserved.
REMARKS
The specimen described above displays common characters with Witchellia gr. laeviuscula (J. de C. Sowerby, 1824) and some primitive Dorsetensia such as D. pinguis (Roemer, 1836), D. hannoverana (Hiltermann, 1939), and D. hebridica Morton. W. laeviuscula has a similar ribbing style, but is more involute and has greater whorl expansion. Also, the section is subtriangular instead of subrectangular. Dorsetensia gr. pinguis specimens have similar coiling, but usually have more developed ribbing.
DISTRIBUTION
This specimen is from the upper part of the Laeviuscula Zone, and is therefore older than D. gr. pinguis, from the JAC22 section, Campillo de Arenas (Jaén Province).
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on pages 842-843, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Ctenoplusia accentifera Lefebvre 1827
Creators: name: Ronkay, Laszlo
name: Behounek, Gottfried
name: Müller, Günter C.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Ctenoplusia
Ctenoplusia accentifera

description: Ctenoplusia accentifera (Lefèbvre, 1827)
(Fig. 32)
Material examined. Oromia Region, Ketebe. 1900 m. V.2009. Leg. Kravchenko V.; Oromia Region, Guder. 2000 m. V.2009. Leg. Kravchenko V.
Literature. Behounek et al. 2010; Dufay & Laporte 1977; Fletcher 1963; Goater et al. 2003; Hacker 1999; Hacker et al. 2001; Hacker et al. 1999; Wiltshire 1990.
General distribution pattern. Widespread in Mediterranean basin in Levant and in Arabian Peninsula. Migrates as far north as the British Isles. In tropical and subtropical Africa: Democratic Republic of Congo, Ethiopia, Ivory Coast, Kenya, Madagascar, South Africa, Tanzania and Uganda.
Distribution in Ethiopia. Throughout medium elevations (especially Shewa region). Common.
Host plants. Recorded on different herbs including Mentha and Coleus spp. (both Lamiaceae).
description: Published as part of Ronkay, Laszlo, Behounek, Gottfried & Müller, Günter C., 2015, PLusiinae (Excl. Abrostolini) (Lepidoptera: Noctuidae) of Ethiopia. A faunistical survey with biogeographical comments, pp. 235-251 in Zootaxa 4013 (2) on page 243, DOI: 10.11646/zootaxa.4013.2.5, http://zenodo.org/record/234589
title: Activité du port de Saint-Malo – 1717 – Hollande
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits manufacturés
subject: cuirs, peaux et laines
subject: produits de la mer
subject: épices et condiments

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1717 avec le port "Hollande"
description: Marchandises au départ de Saint-Malo : peaux de veau ; savons ; sel
description: Catégories de marchandises au départ de Saint-Malo : produits manufacturés ; cuirs, peaux et laines ; produits de la mer ; épices et condiments
description: Coverage: Grand commerce
description: Bibliographic citation: RUELLAND, Jean-Marc. Le Commerce malouin durant les années 1717-1718. DES : Histoire : Rennes, s.d. (Bibliothèque François-Lebrun, MH 1022)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Histomorphometry of the Sural Nerve for Use as a CFNG in Facial Reanimation Procedures
Creators: name: Kehrer, Andreas
name: Hollmann, Katharina S.
name: Klein, Silvan M.
name: Anker, Alexandra M.
name: Tamm, Ernst R.
name: Prantl, Lukas
name: Engelmann, Simon
name: Knoedler, Samuel
name: Knoedler, Leonard
name: Ruewe, Marc
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: axons; axons/analysis; dissection; facial injuries/surgery; facial muscles/innervation; facial nerve/anatomy and histology; humans; nerve fibers; facial paralysis; reconstructive surgical procedures/anatomy and histology
subject: 610 Medizin

description: Facial palsy (FP) is a debilitating nerve pathology. Cross Face Nerve Grafting (CFNG) describes a surgical technique that uses nerve grafts to reanimate the paralyzed face. The sural nerve has been shown to be a reliable nerve graft with little donor side morbidity. Therefore, we aimed to investigate the microanatomy of the sural nerve. Biopsies were obtained from 15 FP patients who underwent CFNG using sural nerve grafts. Histological cross-sections were fixated, stained with PPD, and digitized. Histomorphometry and a validated software-based axon quantification were conducted. The median age of the operated patients was 37 years (5–62 years). There was a significant difference in axonal capacity decrease towards the periphery when comparing proximal vs. distal biopsies (p = 0.047), while the side of nerve harvest showed no significant differences in nerve caliber (proximal p = 0.253, distal p = 0.506) and axonal capacity for proximal and distal biopsies (proximal p = 0.414, distal p = 0.922). Age did not correlate with axonal capacity (proximal: R = −0.201, p = 0.603; distal: R = 0.317, p = 0.292). These novel insights into the microanatomy of the sural nerve may help refine CFNG techniques and individualize FP patient treatment plans, ultimately improving overall patient outcomes.
Dorsetensia regrediens
Creators: name: Sandoval, José
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Cephalopoda
Ammonoidea
Sonniniidae
Dorsetensia
Dorsetensia regrediens

description: Dorsetensia regrediens (Haug, 1893) [m] (Fig. 14U)
Witchellia regrediens Haug, 1893: 318, pl. 10, fig. 7.
Dorsetensia edouardiana – Buckman 1892: 304, pl. 52, figs 8-13, 15-17.
Dorsetensia (Nannina) regrediens – Pavia 1983: 67, pl. 6, fig. 8.
Nannina regrediens – Fernández-López 1985: 119, pl. 10, fig. 2.
Dorsetensia regrediens – Dietze et al. 2011a: 215, pl. 1, figs 19-22.
MATERIAL EXAMINED. — JRi3.28.1.
MEASUREMENTS. — See Table 28.
DESCRIPTION
The only available specimen is small with a discoidal shell, a wide umbilicus, almost vertical umbilical wall, rounded umbilical edge, and gently convex flanks. The ventral region cannot be seen, nor the shape of the aperture, although the specimen looks almost complete. The simple and relatively dense falcoid-sigmoid ribs persist to the end of the spiral.
REMARKS
The most similar species is Dorsetensia edouardiana (d’Orbigny 1845: 392), but it is larger and more involute and has more sigmoid ribbing. According to Dietze et al. (2011a: 217), a LT of D. regrediens has never been selected. The same authors (Dietze et al. 2011a: 217) interpreted D. edouardiana (d’Orbigny, 1845), D. pulchra (Buckman, 1892), D. regrediens (Haug, 1893), and D. lennieri (Brasil, 1894) as microconchiate “species”, which could be the dimorphic couple of D. tessoniana (d’Orbigny, 1845) [M]. However, several of the specimens figured as D. edouardiana by Huf (1968) and by Dietze et al. (2011a) seem rather to represent macroconchiate forms. If the idea proposed by Dietze et al. (2011a) were true, all four taxa would be synonymous.
DISTRIBUTION
The type of D. regrediens is from the “Oolithe ferrugineuse” of Saint-Vigor, near Bayeux, France (Haug 1893; Dietze et al. 2011a). In Frogden Quarry (Dorset, England), D. regrediens occurs in the Inferior Oolite Formation, bed 4b, Lower Bajocian, the Humphriesianum Zone, Romani Subzone, Bj-14 horizon (Callomon & Chandler 1990; Dietze et al. 2011a: 218). In Chaudon, Digne area (SE France), in the Iberian ranges (Spain), and in the Atlas Mountains (Morocco), the species is present in the Romani Subzone, the lower part of the Humphriesianum Zone (Pavia 1983; Fernández-López 1985; Sadki 1996). The only Subbetic specimen is from the Humphriesianum Zone, Romani (= Cycloides) Subzone of Sierra de Ricote (Murcia Region).
description: Published as part of Sandoval, José, 2022, Sonniniidae Ammonitina, Middle Jurassic from Southern Spain: taxonomic, biostratigraphical and palaeobiogeographical analysis, pp. 801-851 in Geodiversitas 44 (27) on page 843, DOI: 10.5252/geodiversitas2022v44a27, http://zenodo.org/record/7150329
Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study
Creators: name: Schauer, Martin Ignaz
name: Jung, Ernst-Michael
name: Platz Batista da Silva, Natascha
name: Akers, Michael
name: Loch, Elena
name: Markowiak, Till
name: Piler, Tomas
name: Larisch, Christopher
name: Neu, Reiner
name: Stroszczynski, Christian
name: Hofmann, Hans-Stefan
name: Ried, Michael
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Io-CEUS; contrast-enhanced ultrasound; intraoperative ultrasound; thoracic surgery; pulmonary tumour
subject: 610 Medizin

description: Background: The intraoperative detection of solitary pulmonary nodules (SPNs) continues to be a major challenge, especially in minimally invasive video-assisted thoracic surgery (VATS). The location, size, and intraoperative frozen section result of SPNs are decisive regarding the extent of lung resection. This feasibility study investigates the technical applicability of intraoperative contrast-enhanced ultrasonography (Io-CEUS) in minimally invasive thoracic surgery. Methods: In this prospective, monocentric clinical feasibility study, n = 30 patients who underwent Io-CEUS during elective minimally invasive lung resection for SPNs between October 2021 and February 2023. The primary endpoint was the technical feasibility of Io-CEUS during VATS. Secondary endpoints were defined as the detection and characterization of SPNs. Results: In all patients (female, n = 13; mean age, 63 ± 8.6 years) Io-CEUS could be performed without problems during VATS. All SPNs were detected by Io-CEUS (100%). SPNs had a mean size of 2.2 cm (0.5–4.5 cm) and a mean distance to the lung surface of 2.0 cm (0–6.4 cm). B-mode, colour-coded Doppler sonography, and contrast-enhanced ultrasound were used to characterize all tumours intraoperatively. Significant differences were found, especially in vascularization as well as in contrast agent behaviour, depending on the tumour entity. After successful lung resection, a pathologic examination confirmed the presence of lung carcinomas (n = 17), lung metastases (n = 10), and benign lung tumours (n = 3). Conclusions: The technical feasibility of Io-CEUS was confirmed in VATS before resection regarding the detection of suspicious SPNs. In particular, the use of Doppler sonography and contrast agent kinetics revealed intraoperative specific aspects depending on the tumour entity. Further studies on Io-CEUS and the application of an endoscopic probe for VATS will follow.
Reconstruction of the Exenterated Orbit with an Island Pericranial Flap: A New Surgical Approach
Creators: name: Kuehnel, Sophia
name: Grimm, András
name: Bohr, Christopher
name: Hosemann, Werner
name: Weber, Rainer K.
name: Ettl, Tobias
name: Kuehnel, Thomas
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Background: 

Reconstruction of the bony socket after orbital exenteration is a matter of much debate. Prompt defect closure with a microvascular flap is desirable but involves a major surgical procedure and hence, places considerable burden on the patient. The new surgical technique presented here permits a technically simpler wound closure with fewer complications after orbital exenteration.
Methods: 

Between May 2014 and June 2022 in the ENT department of Regensburg University, nine patients underwent exenteration and reconstruction with a pericranial flap. The flap was raised via a broken line incision in the forehead or endoscopically, incised in a roughly croissant-like shape, then introduced into the orbit through a tunnel in the eyebrow. A retrospective analysis of the patients and considerations about determining the size, shape, and vascular supply of the flap are presented.
Results: 

Flap healing was uncomplicated in all cases. Only 6 weeks after surgery, the flap was stable, making it possible to start adjuvant therapy and prosthetic rehabilitation swiftly. The flap is adapted to the near cone-shape of the orbit. The mean (± standard deviation) surface area of the measured orbits is (39.58 ± 3.32) cm2. The territory of the angular artery provides the periosteal flap arterial blood supply. Venous drainage is via venous networks surrounding the artery.
Conclusions: 

Use of the pericranial flap makes it possible to close the orbital cavity promptly with minimal donor site defect and a short operating time, thereby minimizing the surgical risk and speeding up physical and psychological recovery.
La consolazione della serietà
Creators: name: Regina, Luciana
Publisher: name: Spazio Filosofico
Year: 2016

description: The essay analyzes the concept of seriousness, both its structures and its contingent aspects. The relevance of this concept for social and cultural life has been increasingly underestimated, and now we are confronted with difficult practical consequences. Seriousness is vital for a proper understanding of the dangerous nature of a situation but also for individuals’ reliability. Possessing a good concept of seriousness is fundamental to foster respect for all kinds of objectivity not only for material but also for moral matters.
description: Spazio Filosofico, 18. Serietà
title: Partition du film Le Livre d'image de Jean-Luc Godard
Creators: name: Lusuardi, Letizia
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Jean-Luc Godard
subject: Le Livre d'Image
subject: Citations
subject: Found-footage
subject: Partition

description: Dans le cadre de ses recherches, Letizia Lusuardi, doctorante à l’ED 267 Arts&Médias (UMR THALIM) de l’Université Sorbonne-Nouvelle à Paris et à l’Université IULM à Milan, a réalisé en 2023 un travail d’identification et de partition de Le Livre d’Image (2018), dernier film de Jean-Luc Godard, composé de citations d’archives (found-footage) provenant de films, de peintures, de programmes télévisés, de photographies, de livres ou de compositions musicales.
La partition, découpant le film en séquences temporelles, prend la forme d’un tableau où chaque moment du film est décrit selon quatre catégories: les images, les écrits, les pistes musicales et enfin les voix off. Ce modèle est repris du travail sur Histoire(s) du cinéma (1989-99) réalisé et publié sur un site internet en 2006 en open access par Céline Scemama, en collaboration avec l'Université Panthéon Sorbonne.
Outre l’accès libre à la partition du film, cette publication sur site internet permet aux utilisateurs référencés de compléter le travail d'identification, ou de suggérer des modifications (environ 80% des œuvres citées sont pour l’instant identifiées). Ceci répond à une volonté d'encourager les pratiques d'interaction et de science participative.
Ce site, développé selon les principes F.A.I.R., est hébergé par la TGIR huma-Num, dans un but de partage et de pérennisation des données de la recherche. Il a été développé en collaboration avec Amal Guha, ingénieur de recherches CNRS, Philippe Agbati, étudiant en informatique à l’IUT Paris Rives de Seine de l’Université Paris-Descartes et stagiaire auprès du laboratoire THALIM, et Valentin Le Moign, pour le collectif Figures Libres, en charge de la conception graphique et du suivi de développement.
Ce projet a pu être réalisé grâce au financement reçu en 2023 à la suite d'un appel à projets en Humanités Numériques - Science & Société de la Direction de la Recherche, de la Valorisation, et des Etudes Doctorales (DiRVED) de l’Université Sorbonne-Nouvelle, et grâce au soutien de l’unité mixte de recherche 7172 THALIM (Théorie et histoire des arts et des littératures de la modernité).