cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kinetics of Interior Loop Formation in Semiflexible Chains
Creators: name: Hyeon, Changbong
name: Thirumalai, D.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Loop formation between monomers in the interior of semiflexible chains describes elementary events in biomolecular folding and DNA bending. We calculate analytically the interior distance distribution function for semiflexible chains using a mean-field approach. Using the potential of mean force derived from the distance distribution function we present a simple expression for the kinetics of interior looping by adopting Kramers theory. For the parameters, that are appropriate for DNA, the theoretical predictions in comparison to the case are in excellent agreement with explicit Brownian dynamics simulations of worm-like chain (WLC) model. The interior looping times ($τ_{IC}$) can be greatly altered in cases when the stiffness of the loop differs from that of the dangling ends. If the dangling end is stiffer than the loop then $τ_{IC}$ increases for the case of the WLC with uniform persistence length. In contrast, attachment of flexible dangling ends enhances rate of interior loop formation. The theory also shows that if the monomers are charged and interact via screened Coulomb potential then both the cyclization ($τ_c$) and interior looping ($τ_{IC}$) times greatly increase at low ionic concentration. Because both $τ_c$ and $τ_{IC}$ are determined essentially by the effective persistence length ($l_p^{(R)}$) we computed $l_p^{(R)}$ by varying the range of the repulsive interaction between the monomers. For short range interactions $l_p^{(R)}$ nearly coincides with the bare persistence length which is determined largely by the backbone chain connectivity. This finding rationalizes the efficacy of describing a number of experimental observations (response of biopolymers to force and cyclization kinetics) in biomolecules using WLC model with an effective persistence length.
description: 38 pages, 8 Figures, J. Chem. Phys. (in press)
Expanding the genetic code for site-directed spin-labeling
Creators: name: Braun, Theresa
name: Drescher, Malte
name: Summerer, Daniel
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Noncanonical amino acids
subject: Bioorthogonal chemistry
subject: Spin labeling
subject: Protein conformation
subject: EPR spectroscopy
subject: Macromolecular dynamics
subject: 570
subject: 540

description: Site-directed spin labeling (SDSL) in combination with electron paramagnetic resonance (EPR) spectroscopy enables studies of the structure, dynamics, and interactions of proteins in the noncrystalline state. The scope and analytical value of SDSL–EPR experiments crucially depends on the employed labeling strategy, with key aspects being labeling chemoselectivity and biocompatibility, as well as stability and spectroscopic properties of the resulting label. The use of genetically encoded noncanonical amino acids (ncAA) is an emerging strategy for SDSL that holds great promise for providing excellent chemoselectivity and potential for experiments in complex biological environments such as living cells. We here give a focused overview of recent advancements in this field and discuss their potentials and challenges for advancing SDSL–EPR studies.
On the Relation Between x-dependence of the Higher Twist Contribution to F_3 and g_1^p - g_1^n
Creators: name: Sidorov, A. V.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compare the higher twist (HT) contribution to the unpolarized structure function $F_3$ with that one to the nonsinglet combination g_1^p - g_1^n of the polarized proton and neutron structure functions using the assumption that the HT contributions to the Gross-Llewellyn Smith and the Bjorken sum rules are similar. We have found, that the relation 1/3x h^{xF_3}(x) ~ 6/g_A h^{g_1^p - g_1^n}(x) is valid for x > 0.1 and for x > 0.2 in the case of LO and NLO QCD approximations, respectively.
description: 6 pages, 3 figures
Resolution of minor size differences in a family of heteroleptic coordination cages by trapped ion mobility ESI-MS
Creators: name: Ebbert, Kristina E.
name: Schneider, Laura
name: Platzek, André
name: Drechsler, Christoph
name: Chen, Bin
name: Rudolf, Robin
name: Clever, Guido H.
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Heteroleptic coordination cages
subject: Supramolecular chemistry
subject: High-resolution trapped ion mobility mass spectrometry (TIMS)
subject: In silico CCS
subject: 540

description: We report a complex system of heteroleptic coordination cages based on the combination of four bismonodentate ligands whose backbones only slightly differ in shape and length. cis-[Pd2L2L’2] assemblies cleanly form after addition of PdII cations to a 1 : 1 mixture of two shape-complementary ligands, each. When three or even all four ligands are used in combination, the unambiguous discrimination of all individual species in the product mixture becomes difficult by conventional NMR spectroscopic and mass spectrometric methods. Due to steric constraints, the system is restricted to the formation of ten different coordination cages in total, two of which are isomeric. We show that high-resolution trapped ion mobility mass spectrometry (TIMS) allows the clear differentiation of all ten species. Observed size trends could be readily reproduced by the calculation of theoretical values for collisional cross sections (CCS) from geometry-optimized models.
Rational design of novel sirtuin 1 activators via structure-activity insights from application of QSAR modeling
Creators: name: Pratiwi, Reny
name: Prachayasittikul, Veda
name: Prachayasittikul, Supaluk
name: Nantasenamat, Chanin
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Sirtuin 1 activator
subject: Aging disease
subject: Alzheimer’s disease
subject: QSAR
subject: Drug design
subject: Structural modification
subject: Cheminformatics
subject: 610

description: Sirtuin 1 (SIRT1) enzyme regulates major cell activities, and its activation offers lucrative therapeutic potentials for aging diseases including Alzheimer’s disease (AD). Regarding the global aging society, continual attention has been given to various chemical scaffolds as a source for the discovery of novel SIRT1 activators since the discovery of the pioneer activator, resveratrol. Understanding structure-activity relationship (SAR) is essential for screening, designing as well as improving the properties of drugs. In this study, an in silico approach based on quantitative structure-activity relationship (QSAR) modeling, was employed for understanding the SAR of currently available SIRT1 fused-aromatic activators (i.e., imidazothiazole, oxazolopyridine, and azabenzimidazole analogs). Three QSAR models constructed using multiple linear regression (MLR) provided good predictive performance (R2 LOOCV = 0.729 - 0.863 and RMSELOOCV = 0.165 - 0.325). An additional novel set of 181 structurally modified compounds were rationally designed according to key descriptors deduced from the QSAR findings and their SIRT1 activities were predicted using the constructed models. In overview, the study provides insightful SAR findings of currently available SIRT1 activators that would be useful for guiding the rational design, screening, and development of further potent SIRT1 activators for managing age-related clinical conditions. A series of promising compounds as well as important scaffolds and molecular properties for potent SIRT1 activator were highlighted. This study demonstrated the efficacious role of QSAR-driven structural modification for the rational design of novel leads.
description: EXCLI Journal;Vol. 18 2019
New right, old Canada : an analysis of the political thought and activities of selected contemporary right-wing organizations
Creators: name: Foster, Bruce Wayne
Publisher: name: University of British Columbia
Year: 2009

description: This thesis is an examination of a moral, cultural and political movement referred to as the New Right. Its specific focus is on three Canadian right-wing organizations, each of which exhibits particular characteristics while at the same time sharing the basic ideological assumptions of the others. These organizations and their particular characteristics are: i) the prolife/profamily REAL Women of Canada and moral conservatism, ii) the anti-bilingualism and anti-Charter Alliance for the Preservation of English in Canada (APEC) and cultural conservatism, and iii) what was arguably the dominant New Right organization during its time — and as I show, among the weaker links in the New Right chain — the Reform Party of Canada and conservative populism. Though Reform was a relatively successful federal political party and the other two are pressure groups, the members in each nevertheless conceive of their respective organizations as vehicles for the authentic views of "the people." In other words, of these organizations see themselves as the true representatives of the majprity of citizens in English-speaking Canada who, they allege, have been deliberately denied political influence commensurate with their numbers since the era of left-leaning, "special interest" politics, policies and moral-cultural values took hold beginning in the late 1960s. By analyzing the New Right phenomenon in general and the three Canadian groups in particular, this project seeks to a) understand the ideological perspective of the movement; b) assess whatever tension, be it normative, policy-driven or strategic, existed between the groups examined herein; and c) determine whether or not such tension was indicative of a fundamental wealkness in the Canadian New Right. I also draw upon three basic questions to frame the analysis presented herein: 1. Is the Canadian New Right ideologically coherent? 2. What explains the New Right's relative lack of success in Canadian politics? 3. Is there a future for the New Right in Canadian politics? I keep these questions in mind throughout the thesis and reconsider them specifically in the concluding chapter.
The effect of heat shock protein 90 inhibitors on histone 4 lysine 20 methylation in bladder cancer
Creators: name: Coban, Nuran
name: Varol, Nuray
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: HSP90
subject: Histone lysine methylation modifications
subject: DNA methylation
subject: Bladder cancer
subject: 610

description: Heat shock protein 90 (HSP90), an ATP-dependent molecular chaperone required for the stability and function of numerous oncogenic signaling, is one of the hallmarks of cancer. Recent years, the studies showed that HSP90 plays a pivotal role in epigenetic pathways. Epigenetic regulation plays an important role in the etiology of bladder cancer. The aim of the present study was to investigate the effect of HSP90 proteins on DNA methylation and the levels of inactivated histone methylation markers in bladder cancers. The cytotoxic effect of geldanamycin (GA), a HSP90-specific inhibitor, in human bladder cancer cell line, T24, was studied by using WST1 (both time and dose-dependent), qPCR for the expression aberration of target genes DNMT1 and WIF-1 and western blot for the protein levels of DNMT1, Histone H4, Histone 4 lysine monomethylation (H4K20me1), Histone 4 lysine trimethylation (H4K20me3), Akt1, pAkt1 (S473) and Lysine methyltransferase 5C (KMT5C). High-dose GA treatment decreased cell proliferation. After the GA treatment, DNMT1 decreased at both transcriptional and translational levels due to Akt1 and pAkt1 (S473) inhibition. Following the GA-induced decrease in DNMT1, re-expression of WIF-1 gene was found at mRNA. In addition, the GA treatment resulted in doseand time-dependent upregulation/downregulation of histone post-translational modifications (H4K20me1 and H4K20me3) and the KMT5C enzyme responsible for these modifications. There was no significant change in the H4 protein level. These findings may offer a new approach for the determination of the molecular effect of HSP90 on epigenetic regulation and the identification of new molecular targets (HSP90 client proteins) for bladder cancer treatment.
description: EXCLI Journal;Vol. 18 2019
Ενέργεια και δίκαιο της θάλασσας: πτυχές του νομικού καθεστώτος του Υγροποιημένου Φυσικού Αερίου (ΥΦΑ) και της μεταφοράς αερίου
Creators: name: Τσόγγαρη, Αγγελική
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Θαλάσσιες μεταφορές
subject: Φυσικό αέριο
subject: LNG

description: Η Ευρώπη τα τελευταία χρόνια, αντιμετωπίζει μεγάλες προκλήσεις σχετικά με την αυξανόμενη ζήτηση του φυσικού αερίου. Σκοπός της παρούσας διπλωματικής εργασίας είναι η ανάλυση του υγροποιημένου φυσικού αερίου, ως ελκυστικότερη πηγή ενέργειας, δεδομένου ότι αποδεικνύεται πιο οικονομικό, ευκολότερο στη χρήση του και πιο φιλικό προς το περιβάλλον. Συγκεκριμένα στη παρούσα μελέτη παρουσιάζεται η σύνθεση και οι ιδιότητες του υγροποιημένου φυσικού αερίου, αλλά και ο κύκλος διεργασίας του από τον εντοπισμό και την εξόρυξή του ως και τη μεταφορά του. Κύριος τρόπος μεταφοράς του φυσικού αερίου είναι διαμέσου των αγωγών, ωστόσο η μεταφορά του ΥΦΑ με τη χρήση αντίστοιχων εξειδικευμένων πλοίων, όπως αναλύεται και στη παρούσα, κερδίζει έδαφος στη μεταφορά ενέργειας παγκοσμίως δεδομένης της τεχνολογικής εξέλιξης.Εν συνεχεία, αντικείμενο της διπλωματικής αυτής εργασίας, είναι η ανάλυση του νομικού καθεστώτος των θαλάσσιων ζωνών, όπως αυτό ρυθμίζεται με βάσει το Διεθνές Δίκαιο και το Δίκαιο της Θάλασσας, καθώς σε αυτές προκύπτουν ζητήματα κυριαρχίας, αλλά και αντικρουόμενα οικονομικά συμφέροντα αναφορικά κυρίως με την εκμετάλλευση υδρογονανθράκων και άλλων μορφών ενέργειας.Κατόπιν, γίνεται αναφορά στις νομικές πτυχές του υγροποιημένου φυσικού αερίου με βάση τη διεθνή, την ευρωπαϊκή και την ελληνική νομοθεσία.Η εργασία ολοκληρώνεται με την ανάλυση πιθανών προβλημάτων και ζητημάτων ασφαλείας που ενδεχομένως να προκύψουν κατά τη διεργασία, τη μεταφορά ή την αποθήκευση του ΥΦΑ, καταλήγοντας, τέλος, στη παράθεση της βιβλιογραφίας.
Relation between the hardness ratio and time in the first 2 seconds for compatible samples of short and long gamma-ray bursts
Creators: name: Qin, Yi-Ping
name: Dong, Yun-Ming
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: In this paper, we randomly selected a sample (sample 1) of long gamma-ray bursts, with its size being the same as that of the short burst group (sample 2) (N=500), from the Current BATSE Bursts Catalog. We randomly selected a short burst and assigned its T90 to each of these long bursts. We thus constructed a long burst sample with both the sample size and the distribution of T90 being the same as those of the short burst sample obtained from the Current BATSE Bursts Catalog. Then we calculated the hardness ratio ($hr_{T}$) over the assigned T90 for the long bursts and over their own T90 for the shout bursts, and studied the relation between the hardness ratio and the corresponding T90 for these two samples. We also calculated the hardness ratio ($hr_{t}$) over the randomly selected 64 ms time intervals within the T90, and investigated the relation between this hardness ratio and the selected 64 ms time interval. In addition, the $hr_{t}$ within and beyond the first 2 seconds for all the long bursts (sample 3; N=1541) were also investigated. We found that the KS probabilities of the distributions of the $hr_{T}$ (7.15337E-15) and $hr_{t}$ (9.54833E-10) for samples 1 and 2 are very small, and the average value of $hr_{T}$ and $hr_{t}$ of short bursts are obviously larger than that of the long bursts. The correlations between log$hr_{T}$ and logT90, and between log$hr_{t}$ and log t, for samples 1 and 2 are different. These show that short and long bursts in the first 2 seconds have different characters and they probably originate from different progenitors. For sample 3, for the two time intervals, the KS probability is 5.35828E-5, which suggests that the hardness ratios in different time intervals for long bursts are also different.
description: 5 pages, 6 figures
Two faces of Hawking radiation and thin-shell emission: pair-creation vs. tunneling
Creators: name: Yeom, Dong-han
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We first revisit Hartle and Hawking's path integral derivation of Hawking radiation. In the first point of view, we interpret that a particle-antiparticle pair is created and the negative energy antiparticle falls into the black hole. On the other point of view, a particle inside the horizon, or beyond the Einstein-Rosen bridge, tunnels to outside the horizon, where this computation requires the analytic continuation of the time. These two faces of the Hawking radiation process can be extended to not only particles but also fields. As a concrete example, we study the thin-shell tunneling process; by introducing the antishell as a negative tension shell, we can give the consistent interpretation for two pictures, where one is a tunneling from inside to outside the horizon using instantons, while the other is a shell-antishell pair-creation. This shows that the Euclidean path integral indeed carries vast physical implications not only for perturbative, but also for non-perturbative processes.
description: 14 pages, 3 figures; Proceedings of the 4th International Conference on Holography, String Theory and Discrete Approach. Talk on August 7, 2020, Hanoi, Vietnam
SOIL FERTILITY MANAGEMENT AND AGRICULTURAL PRODUCTIVITY IN MALAWI
Creators: name: Tchale, Hardwick
name: Sauer, Johannes
name: Tchale, Hardwick
name: Sauer, Johannes
Publisher: name: Unknown
Year: 2006
Subjects: subject: Farm Management
subject: Malawi
subject: smallholder agriculture
subject: soil fertility management
subject: yield response model

description: In this paper we analyze the factors that influence the productivity of maize among smallholder farmers. We use farm-household survey data in order to compare the productivity of smallholder maize production under integrated (ISFM) and chemical-based soil fertility management using a normalized translog yield response model. The results indicate higher maize yield responses for integrated soil fertility management options after controlling for the intensity of fertilizer application, labour intensity, seed rate, land husbandry practices as well as selected policy factors. The estimated model is highly consistent with theoretical conditions. Thus we conclude that the use of ISFM improves maize productivity, compared to the use of inorganic fertilizer only. Since most farmers in the maize-based farming systems are crowded out of the agricultural input market and can hardly afford optimal quantities of inorganic fertilizer, enhancement of ISFM is likely to increase their maize productivity. We finally highlight areas of policy support needed to enhance ISFM uptake in smallholder maize-based farming systems.
Non--Adiabatic Contributions to the Free Energy from the Electron--Phonon Interaction for Na, K, Al, and Pb
Creators: name: Bock, N.
name: Coffey, D.
name: Wallace, Duane C.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We calculate the non--adiabatic contributions to the free energy of metals due to the electron--phonon interaction at intermediate temperatures, $0 \leqslant k_{B} T < ε_{F}$ for four different nearly free electron metals, Na, K, Al, and Pb. We calculate its value for $T = 0$ which has not been calculated before and we study its low--temperature behavior.
STALLBAUKONFLIKTE IN NICHT-VEREDLUNGSREGIONEN: EMPIRISCHE ANALYSE UND FOLGERUNGEN FUR EFFIZIENTE EMPIRISCHE ANALYSE UND FOLGERUNGEN FUR EFFIZIENTE GOVERNANCESTRUKTUREN
Creators: name: Gerlach, Sabine
name: Spiller, Achim
name: Gerlach, Sabine
name: Spiller, Achim
Publisher: name: Unknown
Year: 2006
Subjects: Farm Management

description: Auf Basis einer empirischen Untersuchung zu einem Stallbaukonflikt kann gezeigt werden, dass entgegen der öffentlichen Diskussion besonders die Einschätzung der persönlichen Be-einträchtigung durch einen Stallneubau zur Ablehnung führt. Tier- und Umweltschutzargrum-ente spielen zwar in der Auseinandersetzung eine prominente Rolle, sind aber - wie eine Reg-ressionsanalyse zeigt - wenig entscheidungsrelevant. Stallbaukonflikte und die Entzerrung der Tierproduktion können nur durch gesetzlich eindeutige Regelungen gelöst werden. Verhand-lungen im Rahmen von Netzwerken tragen nicht zur Konfliktlösung bei, da es sich primär um einen Nimby-Konflikt handelt.
Participatory Design and Making: Towards People Responsive Public Spaces
Creators: name: Sanya, Tom
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 330411
subject: Urban design
classificationCode: 330314
subject: Sustainable design
classificationCode: 330405
subject: Public participation and community engagement

description: This paper presents an action research project that is teamwork between UCT academics and Sustainable Urban Neighbourhoods (SUN). SUN is a consultant for the implementation of the City of Cape Town’s Violence Prevention through Urban Upgrading (VPUU) programme. The research is underpinned by the constructivist viewpoint that knowledge creation, application and understandings are a result of multiple actors – with even poor beneficiary communities having a positive contribution to make. The research project reacts to the overt paradox of unemployment/underemployment in a context of numerous unfulfilled needs as experienced by the many unfortunate people excluded from the formal city. Borrowing from the Scandinavian active welfare approach, the project makes use of people’s residual capabilities to design and construct a small public space within one of the interstitial spaces in Monwabisi Park in Khayelitsha informal settlement. The public space, which is design around a municipal water-point, is conceived within a wider urban planning/design framework as an Early Childhood Development (ECD) Centre. It is multifunctional place for children who cannot afford daycare facilities to play in a crime-free environment. The water-point will draw adults to the site and so achieve two aims (1) safety and supervision for the children via adult surveillance (2) attraction of child care-givers to a place where they can interact informally with ECD staff for information exchange, identification of problems and assistance requirements assessment (child nutrition, health, safety, education and development). The space will also provide a platform for other community activities such as a gathering point for the Monwabisi Park Neighbourhood Watch (NHW). This project is conceived as the first designed ECD public space in a future network of several similar such small public spaces. Although this project is modest in scale, its potentially beneficial implications for community wellbeing, emergent academic insights and development of reciprocated partnerships are immense.The paper’s thesis is that participatory approaches can facilitate empowerment of communities through skills transfer while offering a viable framework for optimal utilisation of limited resources to create safe and responsive urban habitats. The conclusions of the paper look at the challenges and possibilities inherent in active welfare as a synergetic umbrella for efforts by the general public, governments, professionals, civil society, the private sector, and academics aimed at realistically facing up to the informal settlement challenge.
STRUCTURAL SOCIAL CAPITAL AND ECONOMIC PERFORMANCE: FINDINGS OF EMPIRICAL FARM DATA IN THE CZECH REPUBLIC
Creators: name: Wolz, Axel
name: Fritzsch, Jana
name: Pencakova, Jitka
name: Wolz, Axel
name: Fritzsch, Jana
name: Pencakova, Jitka
Publisher: name: Unknown
Year: 2006
Subjects: subject: Farm Management
subject: corporate farms
subject: private farms
subject: social capital
subject: cross sectional models
subject: Czech Republic

description: With the change of the political regime in Central and Eastern Europe, both managers of corporate farms and newly established private farmers had to adjust to the rules of the market economy. Among both groups, some are economically more successful than others. In general, a varying adoption of production factors is identified as being of influence. Whether their ability to collaborate with other farms is an additional factor which has been discussed under the concept of social capital since quite some time will be analyzed in this paper. Based on the findings of a survey among a sample of 62 farms in the Czech Republic it can be shown by adopting factor and multiple regression analysis that social capital is indeed a significant factor determining the level of agricultural income.
Ο περιβαλλοντικός αντίκτυπος της κρουαζιέρας σύμφωνα με τα Παραρτήματα της MARPOL I,IV,V,VI
Creators: name: Μπουντούρη, Όλγα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Αγορά κρουαζιέρας
subject: MARPOL
subject: Περιβάλλον
subject: Ειδικές περιοχές
subject: Προορισμοί κρουαζιέρας
subject: Λιμενικές Αρχές
subject: Απορρίμματα
subject: Λύματα
subject: Αέριοι ρύποι
subject: Λιμενικές εγκαταστάσεις

description: Η παρούσα διπλωματική εργασία εξετάζει τον περιβαλλοντικό αντίκτυπο της δραστηριότητα κρουαζιέρας σε διάφορους προσφιλείς προορισμούς της αγοράς, με βάση τα πέντε από τα έξι Παραρτήματα της Σύμβασης MARPOL, του Διεθνούς Οργανισμού Ναυτιλίας (IMO). Παρόλο που η πρόσφατη διαθέσιμη βιβλιογραφία στις ροές αποβλήτων κρουαζιέρας είναι σχετικά περιορισμένη, σκοπός της εργασίας είναι να εξετάσει εάν οι εταιρείες κρουαζιέρας τηρούν τα πρότυπα IMO για τη ρύπανση της θάλασσας και του αέρα, καθώς επίσης, εάν οι λιμενικές αρχές στους κλασικούς και αναδυόμενους προορισμούς κρουαζιέρας είναι έτοιμες να διαχειριστούν και να αντιμετωπίσουν τις περιβαλλοντικές επιπτώσεις των εν λόγω μεγάλων πλωτών ξενοδοχείων. Ακόμα, θα γίνει αναφορά στην οικονομική συμβολή της κρουαζιέρας στους λιμένες υποδοχής και τέλος θα γίνει προσπάθεια να απαντηθεί το ερώτημα εάν τα οικονομικά οφέλη της κρουαζιέρας μπορούν να αντισταθμίσουν τον περιβαλλοντικό της αντίκτυπο.
Simulating cosmic structure formation with the GADGET-4 code
Creators: name: Springel, Volker
name: Pakmor, Rüdiger
name: Zier, Oliver
name: Reinecke, Martin
Publisher: name: arXiv
Year: 2020
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Numerical methods have become a powerful tool for research in astrophysics, but their utility depends critically on the availability of suitable simulation codes. This calls for continuous efforts in code development, which is necessitated also by the rapidly evolving technology underlying today's computing hardware. Here we discuss recent methodological progress in the GADGET code, which has been widely applied in cosmic structure formation over the past two decades. The new version offers improvements in force accuracy, in time-stepping, in adaptivity to a large dynamic range in timescales, in computational efficiency, and in parallel scalability through a special MPI/shared-memory parallelization and communication strategy, and a more-sophisticated domain decomposition algorithm. A manifestly momentum conserving fast multipole method (FMM) can be employed as an alternative to the one-sided TreePM gravity solver introduced in earlier versions. Two different flavours of smoothed particle hydrodynamics, a classic entropy-conserving formulation and a pressure-based approach, are supported for dealing with gaseous flows. The code is able to cope with very large problem sizes, thus allowing accurate predictions for cosmic structure formation in support of future precision tests of cosmology, and at the same time is well adapted to high dynamic range zoom-calculations with extreme variability of the particle number density in the simulated volume. The GADGET-4 code is publicly released to the community and contains infrastructure for on-the-fly group and substructure finding and tracking, as well as merger tree building, a simple model for radiative cooling and star formation, a high dynamic range power spectrum estimator, and an initial conditions generator based on second-order Lagrangian perturbation theory.
description: 82 pages, 65 figures, accepted by MNRAS, for the code see https://wwwmpa.mpa-garching.mpg.de/gadget4
MCT4 promotes cell proliferation and invasion of castration-resistant prostate cancer PC-3 cell line
Creators: name: Sun, Qing
name: Hu, Liang-Liang
name: Fu, Qiang
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Prostate cancer
subject: MCT4
subject: Aerobic glycolysis
subject: siRNA
subject: Cell viability
subject: 610

description: Prostate cancer (PCa) is one of the leading causes of cancer-related death in men. Blocking androgen receptor (AR) signaling is an effective treatment strategy for the treatment of advanced metastatic disease of PCa in men. However, the method of blocking AR signaling is not suitable for castration-resistant prostate cancer (CRPC), and the treatment of CRPC is still clinically difficult. It has recently been reported that MCT4 is a plasma membrane transporter that mediates the secretion of lactic acid from aerobic glycolysis by cancer cells. Its expression is up-regulated in PCa and plays an important role in the carcinogenesis of PCa, but the underlying mechanism is hardly known. The MCT4 gene of PC-3 cell line was knocked down by siRNA, then MCT4 mRNA and protein was detected by real-time PCR and western blotting, respectively. CCK-8, Transwell migration assay, Flow cytometry, and TUNEL methods were used to detect the proliferation, invasion and apoptosis of PC-3 cells by MCT4 knockdown, and the expression of invasion-related proteins (MCT4) was detected by western blot analysis. The treatment of PC-3 with candidate MCT4 siRNAs led to marked inhibition of MCT4 expression in both mRNA and protein level. MCT4 knockdown inhibits PC-3 cell proliferation and facilitates apoptosis. Furthermore, MCT4 promoted the invasion capabilities of PC-3 cells by regulating invasion-related genes, such as VEGF, CD147, MMP2 and MMP9. In conclusion, MCT4 promotes oncogenic process of PCa may, as least partially, by inhibiting cell apoptosis and accelerating cell proliferation as well as invasion abilities of PC-3 cells. VEGF, CD147, MMP2 and MMP9 are important downstream genes of MCT4 in facilitating cell invasion.
description: EXCLI Journal;Vol. 18 2019
PERFORMANCE EVALUATION OF VARIOUS CNN ARCHITECTURES FOR PLANT IMAGE CLASSIFICATION WITH DEEP LEARNING
Creators: name: VAIDEHI V
Publisher: name: Zenodo
Year: 2024
Subjects: Classification, Augmented Dataset, CNN Model, ResNet Model.

description: Abstract

The purpose of the study is to analyze and compare the classification and identification results taken from various deep learning models and techniques used for computer vision 2D object classification tasks. Here for this study 6 different plant datasets were taken. Firstly, the work starts with CNN architecture from scratch with an accuracy result 73.1%. Again when it is trained with the augmented datas, the performance of the work gets increased as 82.88%. The aim of the current paper is to check the performance when pre-trained Networks were applied. For that, using the same dataset one of the CNN model, ResNet50 were taken and after that this paper will check the performance and finally compares with other CNN model to classify the datasets and conclude the comparison results.
Re-Examining the Evidence of the Hercules-Corona-Borealis Great Wall
Creators: name: Christian, Sam
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In the Λ-CDM paradigm of cosmology, anisotropies larger than 260 Mpc shouldn't exist. However, the existence of the Hercules-Corona Borealis Great Wall (HCB) is purported to challenge this principle by some with an estimated size exceeding 2000 Mpc. Recently, some have challenged the assertion of the existence of the HCB, attributing the anisotropy to sky exposure effects. It has never been explained why the original methods purporting the existence of the HCB produce anisotropies, even if sky-exposure effects are taken into account. In this paper, I apply the methods of the original papers purporting the existence of the HCB in various Monte-Carlo simulations that assume isotropy to analyze the empirical meaning of the significance levels of the original tests used. I find that, although the statistical tests at first glance show significant anisotropies present in the suspect sample, Monte-Carlo simulations can easily reproduce the sample in most cases, and if not, the differences can be accounted for by other statistical considerations. An updated sample raises the probability of drawing the observed clustering from an isotropic sample ten-fold in some cases. Thus the statistical tests used in prior studies overestimate the significance of the observed anisotropy, and an updated sample returns even less significant probabilities. Given the ability to reproduce the observed anisotropy in Monte-Carlo simulations, the new, higher probabilities of being drawn from isotropy for an updated sample, and the work of previous papers attributing anisotropies to sky-selection effects, the existence of the HCB must be treated as doubtful at best.
description: 6 pages, 5 figures. Accepted for publication in MNRAS
title: Cytotoxicity and apoptogenic properties of the standardized extract of Portulaca oleracea on glioblastoma multiforme cancer cell line (U-87)
title: a mechanistic study
titleType: AlternativeTitle
Creators: name: Baradaran Rahimi, Vafa
name: Mousavi, Seyed Hadi
name: Haghighi, Soroush
name: Soheili-Far, Sina
name: Askari, Vahid Reza
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Glioblastoma multiforme (GBM)
subject: ROS
subject: NF-kB
subject: U-87 cell
subject: Portulaca oleracea
subject: Nitric oxide
subject: 610

description: The traditional uses of Portulaca oleracea L. (PO) with anti-inflammatory and anti-cancer activity as well as antioxidants properties were expressed previously. Glioma is considered the most common primary brain tumor and its malignant form is the most lethal adult brain tumor, that glioblastoma covers about 50 % of glioma tumors. The present study was aimed to evaluate the cytotoxicity and apoptogenic effects of the hydro-ethanolic extract of PO on human glioblastoma cancer cell line (U-87) and the role of NF-kB. Cytotoxicity of the extract in the presence or absence of Vitamin C was evaluated using MTT assay, and the following hypotonic PI and SubG1 peak were performed. Moreover, the reactive oxygen species (ROS), the level of NF-kB protein and nitric oxide (NO) production were investigated. The extract had cytotoxicity and apoptogenic effects on U-87 cells in both the concentration and time-dependent manners. The mechanism of cytotoxicity and apoptosis induction of the extract at the first hours of incubation and low concentrations were dependent on ROS. However, the toxicity was replaced with NO pathway with time-lapse and higher concentrations. Results also indicated that the extract acts as an NF-kB inhibitor with concentration and time-dependent manners. The present study may suggest the anti-NF-kB activity of PO along with two upstream ROS and NO mechanisms. Furthermore, the extract as ethnobotanical may be used as adjunctive anti-cancer therapy against glioblastoma multiforme.
description: EXCLI Journal;Vol. 18 2019
Pd(II) coordination sphere engineering: pyridine cages, quinoline bowls, and heteroleptic pills binding one or two fullerenes
Creators: name: Chen, Bin
name: Holstein, Julian J.
name: Horiuchi, Shinnosuke
name: Hiller, Wolf G.
name: Clever, Guido H.
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Supramolecular chemistry
subject: Self assembly
subject: Coordination cage
subject: Coordination bowl
subject: Fullerene
subject: Functionalization
subject: Fullerene separation
subject: 540

description: Fullerenes and their derivatives are of tremendous technological relevance. Synthetic access and application are still hampered by tedious purification protocols, peculiar solubility, and limited control over regioselective derivatization. We present a modular self-assembly system based on a new low-molecular-weight binding motif, appended by two palladium(II)-coordinating units of different steric demands, to either form a [Pd2L14]4+ cage or an unprecedented [Pd2L23(MeCN)2]4+ bowl (with L1 = pyridyl, L2 = quinolinyl donors). The former was used as a selective induced-fit receptor for C60. The latter, owing to its more open structure, also allows binding of C70 and fullerene derivatives. By exposing only a fraction of the bound guests’ surface, the bowl acts as fullerene protecting group to control functionalization, as demonstrated by exclusive monoaddition of anthracene. In a hierarchical manner, sterically low-demanding dicarboxylates were found to bridge pairs of bowls into pill-shaped dimers, able to host two fullerenes. The hosts allow transferring bound fullerenes into a variety of organic solvents, extending the scope of possible derivatization and processing methodologies.
title: Stress test και πιστοληπτική ικανότητα
title: Stress test and creditworthiness
titleType: AlternativeTitle
Creators: name: Βρόντου, Γεωργία
name: Vrontou, Georgia
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Κίνδυνος
subject: Stress test
subject: Πιστοληπτική ικανότητα

description: Σε αυτή την εργασία εξετάζουμε τα stress test που διεξάγονται από εποπτικές αρχές με σκοπό τον έλεγχο της ικανότητας περιφερειακών τραπεζών να υπομείνουν των αντίξοων οικονομικών συνθηκών που μπορεί να παρουσιαστούν, διατηρώντας παράλληλα την κεφαλαιακή τους επάρκεια. Παράλληλα, γίνεται αναφορά στα μη εξυπηρετούμενα δάνεια και στην εξέλιξη τους τα τελευταία 20 χρόνια. Επιπροσθέτως, αναφερόμαστε στις ελληνικές συστημικές τράπεζες με ειδική μνεία στα αποτελέσματα των stress test τους και ολοκληρώνουμε με κριτική ανάλυση στον μηχανισμό των stress test.
Hierarchical coupled routing-charging model of electric vehicles, stations and grid operators
Creators: name: Sohet, Benoît
name: Hayel, Yezekael
name: Beaude, Olivier
name: Jeandin, Alban
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optimization and Control (math.OC)
subject: Computer Science and Game Theory (cs.GT)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Electric Vehicles' (EVs) growing number has various consequences, from reducing greenhouse gas emissions and local pollution to altering traffic congestion and electricity consumption. More specifically, decisions of operators from both the transportation and the electrical systems are coupled due to EVs' decisions. Thus, decision-making requires a model of several interdependent operators and of EVs' both driving and charging behaviors. Such a model is suggested for the electrical system in the context of commuting, which has a typical trilevel structure. At the lower level of the model, a congestion game between different types of vehicles gives which driving paths and charging stations (or hubs) commuters choose, depending on travel duration and consumption costs. At the middle level, a Charging Service Operator sets the charging prices at the hubs to maximize the difference between EV charging revenues and electricity supplying costs, which are decided by the Electrical Network Operator at the upper level of the model, whose goal is to reduce grid costs. This trilevel optimization problem is solved using an optimistic iterative bilevel algorithm and simulated annealing. The sensitivity of this trilevel model to exogenous parameters such as the EV penetration and an incentive from a transportation operator is illustrated on realistic urban networks.
description: 12 pages, 9 figures, published in IEEE Transactions on Smart Grid
Analysis and evaluation of fiber orientation reconstruction methods
Creators: name: Breuer, Kevin
name: Stommel, Markus
name: Korte, Wolfgang
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: Maximum entropy
subject: Spherical harmonics
subject: Fiber orientation
subject: ODF
subject: Reconstruction
subject: Injection molding
subject: 620
subject: 670

description: The calculation of the fiber orientation of short fiber-reinforced plastics with the Fokker–Planck equation requires a considerable numerical effort, which is practically not feasible for injection molding simulations. Therefore, only the fiber orientation tensors are determined, i.e., by the Folgar–Tucker equation, which requires much less computational effort. However, spatial fiber orientation must be reconstructed from the fiber orientation tensors in advance for structural simulations. In this contribution, two reconstruction methods were investigated and evaluated using generated test scenarios and experimentally measured fiber orientation. The reconstruction methods include spherical harmonics up to the 8th order and the method of maximum entropy, with which a Bingham distribution is reconstructed. It is shown that the quality of the reconstruction depends massively on the original fiber orientation to be reconstructed. If the original distribution can be regarded as a Bingham distribution in good approximation, the method of maximum entropy is superior to spherical harmonics. If there is no Bingham distribution, spherical harmonics is more suitable due to its greater flexibility, but only if sufficiently high orders of the fiber orientation tensor can be determined exactly.
description: J. Compos. Sci.;3(3)
Decays of eta and eta-prime within a chiral unitary approach
Creators: name: Borasoy, B.
name: Nissler, R.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Various decays of eta and eta-prime are investigated within the framework of U(3) chiral effective field theory in combination with a relativistic coupled-channels approach. Final state interactions are included by deriving s- and p-wave interaction kernels for meson-meson scattering from the chiral effective Lagrangian and iterating them in a Bethe-Salpeter equation. Very good agreement with experimental data is achieved.
description: 7 pages, 2 figures, 3 tables, presented at the Eta'05 Workshop
Η εκπαιδευτική μονάδα ως φορέας διαπολιτισμικότητας: απόψεις εκπαιδευτικών και διευθυντών σχολείων πρωτοβάθμιας εκπαίδευσης
Creators: name: Καραχρήστου, Μαρία-Θεοδώρα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Διαπολιτισμικότητα
subject: Διαχείριση ετερότητας
subject: Εκπαιδευτικοί
subject: Σχολική ηγεσία

description: Στη σύγχρονη εποχή, καθημερινά, παρατηρούνται ραγδαίες αλλαγές σε πολλούς τομείς της ανθρώπινης δραστηριότητας. Λόγω αυτών των αλλαγών τα άτομα αναγκάζονται να διαμορφώσουν την ζωή τους στα νέα δεδομένα που τους επιτάσσει η νέα πραγματικότητα και συχνά εγκαταλείπουν την χώρα τους, αναζητώντας ένα καλύτερο μέλλον σε κάποια άλλη. Στην χώρα υποδοχής τα πράγματα δεν είναι πάντοτε εύκολα για τους/τις μετανάστες/στριες και ακόμα περισσότερες δυσκολίες συναντούν τα παιδιά, ιδιαίτερα στο σχολικό περιβάλλον. Το σχολείο αποτελεί τον χώρο όπου τα παιδιά περνούν πολλές ώρες της ημέρας τους. Εκεί γνωρίζουν άλλα άτομα, διαφορετικά από εκείνα, κοινωνικοποιούνται και αλληλεπιδρούν μαζί τους. Σκοπός της εκπαιδευτικής μονάδας είναι να καταφέρει να γεφυρώσει το χάσμα που προκύπτει μεταξύ των μαθητών/τριων λόγω της ξεχωριστής ταυτότητάς τους. Εκπαιδευτικοί και σχολική ηγεσία οφείλουν να σχεδιάσουν και να υιοθετήσουν πρακτικές για να επιλύουν προβλήματα, να ενισχύουν την συνεργασία και την επικοινωνία όλων των μελών της σχολικής κοινότητας, στοχεύοντας στην προαγωγή της διαπολιτισμικότητας και στην ακολουθία των αρχών της διαπολιτισμικής εκπαίδευσης, προκειμένου να δημιουργήσουν ένα σχολικό περιβάλλον φιλικό προς όλα τα παιδιά. Κύριος σκοπός λοιπόν της παρούσας διπλωματικής εργασίας είναι να διερευνήσει αν οι εκπαιδευτικές μονάδες αποτελούν στην πραγματικότητα έναν από τους σημαντικότερους φορείς προαγωγής της διαπολιτισμικότητας, καθώς και να καταγράψει τις στάσεις και αντιλήψεις τόσο των εκπαιδευτικών όσο και των διευθυντικών στελεχών σε θέματα σχετικά με αυτή.
Convergent close-coupling calculations of two-photon double ionization of helium
Creators: name: Kheifets, A. S.
name: Ivanov, I. A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We apply the convergent close-coupling (CCC) formalism to the problem of two-photon double ionization of helium. The electron-photon interaction is treated perturbatively whereas the electron-electron interaction is included in full. The integrated two-photon double ionization cross-section is substantially below non-perturbative literature results. However, the pattern of the angular correlation in the two-electron continuum is remarkably close to the non-perturbative time-dependent close-coupling calculation of Hu {\em et al} [J. Phys. {\bf B38}, L35 (2005)]
description: 15 pages, 6 figures
Growth of Hydrodynamic Perturbations in Accretion Disks: Possible Route to Non-Magnetic Turbulence
Creators: name: Mukhopadhyay, Banibrata
name: Afshordi, Niayesh
name: Narayan, Ramesh
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We study the possible origin of hydrodynamic turbulence in cold accretion disks such as those in star-forming systems and quiescent cataclysmic variables. As these systems are expected to have neutral gas, the turbulent viscosity is likely to be hydrodynamic in origin, not magnetohydrodynamic. Therefore MRI will be sluggish or even absent in such disks. Although there are no exponentially growing eigenmodes in a hydrodynamic disk, because of the non-normal nature of the eigenmodes, a large transient growth in the energy is still possible, which may enable the system to switch to a turbulent state. For a Keplerian disk, we estimate that the energy will grow by a factor of 1000 for a Reynolds number close to a million.
description: 4 pages; to appear in the Proceedings of COSPAR Colloquium "Spectra & Timing of Compact X-ray Binaries," January 17-20, 2005, Mumbai, India; prepared on the basis of the talk presented by Mukhopadhyay