cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Existence of new nonlocal field theory on noncommutative space and spiral flow in renormalization group analysis of matrix models
Creators: name: Kawamoto, Shoichi
name: Kuroki, Tsunehide
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the previous study, we formulate a matrix model renormalization group based on the fuzzy spherical harmonics with which a notion of high/low energy can be attributed to matrix elements, and show that it exhibits locality and various similarity to the usual Wilsonian renormalization group of quantum field theory. In this work, we continue the renormalization group analysis of a matrix model with emphasis on nonlocal interactions where the fields on antipodal points are coupled. They are indeed generated in the renormalization group procedure and are tightly related to the noncommutative nature of the geometry. We aim at formulating renormalization group equations including such nonlocal interactions and finding existence of nontrivial field theory with antipodal interactions on the fuzzy sphere. We find several nontrivial fixed points and calculate the scaling dimensions associated with them. We also consider the noncommutative plane limit and then no consistent fixed point is found. This contrast between the fuzzy sphere limit and the noncommutative plane limit would be manifestation in our formalism of the claim given by Chu, Madore and Steinacker that the former does not have UV/IR mixing, while the latter does.
description: 1+47 pages, no figure; Ver. 2, references and some comments are added; Ver. 3, typos corrected. Version to appear in JHEP
ЛОГИСТИЧЕСКАЯ ЦЕПОЧКА ИНВЕСТИЦИОННОГО ПРОЕКТА ПО СТРОИТЕЛЬСТВУ ЗАВОДА ПО ПЕРЕРАБОТКЕ АКБ В РЕСПУБЛИКЕ ТАТАРСТАН
Creators: name: Е. Д. Денисова
name: С. В. Пирогова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: аккумуляторные батареи
загрязнение окружающей среды
логистическая цепочка
пункты приема АКБ

description: В работе дано основное понимание важности по сбору и утилизации аккумуляторных батарей, данная деятельность должна быть организована по всей стране, т.к. забота об окружающей природе сегодня становится важным показателем социально-экономического развития. В статье авторы сделали упор не на расчетах по экономической эффективности строительства завода по переработке АКБ, а на выстраивании логистической цепочки по сбору отработанных АКБ в крупных городах Татарстана
СТРАТЕГИЧЕСКИЕ АЛЬЯНСЫ ТНК ПОТРЕБИТЕЛЬСКОГО СЕКТОРА В ЭПОХУ ГЛОБАЛИЗАЦИИ
Creators: name: И. Б. Долженко
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: стратегические альянсы
межфирменная кооперация
глобальная производственная система
транснациональные корпорации (ТНК)
потребительский сектор
конкурентные преимущества

description: Статья посвящена вопросам операций стратегических альянсов ТНК потребительского сектора в эпоху глобализации. Исследованы глобальные факторы, способствующие созданию стратегических альянсов ТНК потребительского сектора. Рассмотрены характеристики успешных стратегических альянсов, достоинства и недостатки этой формы межфирменного сотрудничества. Проведено исследование экономического и внеэкономического эффектов от участия в альянсах. Исследованы особенности стратегических альянсов ТНК потребительского сектора на примере альянсов ТНК Unilever, Nestle, Coca Cola.
Phase 1 study of seviteronel, a selective CYP17 lyase and androgen receptor inhibitor, in women with estrogen receptor-positive or triple-negative breast cancer
Creators: name: Eisner, J.R.
name: Carey, L.A.
name: Traina, T.A.
name: DaCosta, N.
name: Gucalp, A.
name: Bardia, A.
name: Blackwell, K.L.
name: Gabrail, N.
name: Baskin-Bey, E.S.
name: Danso, M.
name: Ali, H.
Publisher: name: Springer New York LLC
Year: 2018

description: Purpose: Seviteronel (INO-464) is an oral, selective cytochrome P450c17a (CYP17) 17,20-lyase (lyase) and androgen receptor inhibitor with in vitro and in vivo anti-tumor activity. This open-label phase 1 clinical study evaluated safety, tolerability, pharmacokinetics (PK), and activity of once-daily (QD) seviteronel in women with locally advanced or metastatic TNBC or ER+ breast cancer. Methods: Seviteronel was administered in de-escalating 750, 600, and 450 mg QD 6-subject cohorts. The 750 mg QD start dose was a phase 2 dose determined for men with castration-resistant prostate cancer in (Shore et al. J Clin Oncol 34, 2016). Enrollment at lower doses was initiated in the presence of dose-limiting toxicities (DLTs). The primary objective of this study was to determine seviteronel safety, tolerability, and MTD. The secondary objectives included description of its PK in women and its initial activity, including clinical benefit rate at 4 (CBR16) and 6 months (CBR24). Results: Nineteen women were enrolled. A majority of adverse events (AEs) were Grade (Gr) 1/2, independent of relationship; the most common were tremor (42%), nausea (42%), vomiting (37%), and fatigue (37%). Four Gr 3/4 AEs (anemia, delirium, mental status change, and confusional state) deemed possibly related to seviteronel occurred in four subjects. DLTs were observed at 750 mg (Gr 3 confusional state with paranoia) and 600 mg (Gr 3 mental status change and Gr 3 delirium) QD, with none at 450 mg QD. The recommended phase 2 dose (RP2D) was 450 mg QD, and at the RP2D, 4 of 7 subjects reached at least CBR16 (2 TNBC subjects and 2 ER+ subjects achieved CBR16 and CBR24, respectively); no objective tumor responses were reported. Conclusions: Once-daily seviteronel was generally well tolerated in women with and 450 mg QD was chosen as the RP2D.
Homologous recombination deficiency and host anti-tumor immunity in triple-negative breast cancer
Creators: name: Domchek, S.M.
name: Newman, L.
name: Aparicio, S.
name: Stover, D.G.
name: Carey, L.A.
name: Winer, E.P.
name: Loi, S.
name: Sledge, G.W.
name: Telli, M.L.
Publisher: name: Springer New York LLC
Year: 2018

description: Purpose: Triple-negative breast cancer (TNBC) is associated with worse outcomes relative to other breast cancer subtypes. Chemotherapy remains the standard-of-care systemic therapy for patients with localized or metastatic disease, with few biomarkers to guide benefit. Methods: We will discuss recent advances in our understanding of two key biological processes in TNBC, homologous recombination (HR) DNA repair deficiency and host anti-tumor immunity, and their intersection. Results: Recent advances in our understanding of homologous recombination (HR) deficiency, including FDA approval of PARP inhibitor olaparib for BRCA1 or BRCA2 mutation carriers, and host anti-tumor immunity in TNBC offer potential for new and biomarker-driven approaches to treat TNBC. Assays interrogating HR DNA repair capacity may guide treatment with agents inducing or targeting DNA damage repair. Tumor infiltrating lymphocytes (TILs) are associated with improved prognosis in TNBC and recent efforts to characterize infiltrating immune cell subsets and activate host anti-tumor immunity offer promise, yet challenges remain particularly in tumors lacking pre-existing immune infiltrates. Advances in these fields provide potential biomarkers to stratify patients with TNBC and guide therapy: induction of DNA damage in HR-deficient tumors and activation of existing or recruitment of host anti-tumor immune cells. Importantly, these advances provide an opportunity to guide use of existing therapies and development of novel therapies for TNBC. Efforts to combine therapies that exploit HR deficiency to enhance the activity of immune-directed therapies offer promise. Conclusions: HR deficiency remains an important biomarker target and potentially effective adjunct to enhance immunogenicity of ‘immune cold’ TNBCs.
ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ ФОРМИРОВАНИЯ И ВНЕДРЕНИЯ ИННОВАЦИОННЫХ ПРОЦЕССОВ В СТРАТЕГИЧЕСКОМ УПРАВЛЕНИИ
Creators: name: А. В. Доронина
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: инновации
инновационный процесс
стратегия
стратегическое управление
конкурентоспособность

description: В статье проведен комплексный обзор и анализ теоретических аспектов ключевых понятий инновационной составляющей стратегического управления: «инновации», «инновационный процесс», «стратегия» и «стратегическое управление». На основе рассмотренных трактовок сформированы комплексные определения, позволяющие компаниям выделить аспекты, характерные непосредственно для их направления инновационных преобразований деятельности.
Weight gain in hormone receptor-positive (HR+) early-stage breast cancer: is it menopausal status or something else?
Creators: name: Deal, A.M.
name: Nyrop, K.A.
name: Choi, S.K.
name: Muss, H.B.
name: Shachar, S.S.
name: Wheless, A.
name: Lee, J.T
name: Carey, L.A.
Publisher: name: Springer New York LLC
Year: 2018

description: Purpose: This study investigates weight trajectories in pre- versus postmenopausal breast cancer (BC) survivors diagnosed with hormone receptor-positive tumors, with a specific focus on discerning menopausal status and type of endocrine treatment (ET) as risk factors for weight gain during ET. Methods: We conducted a retrospective review of electronic medical records. Descriptive statistics and Chi-squared and t tests were used to compare pre- and postmenopausal women. Chi-squared tests and ANOVA were used for within-group associations between patient characteristics and weight trajectories. Log-binomial regression models were used to estimate relative risk for weight gain. Results: The final sample was 32% premenopausal (n = 140) and 68% postmenopausal (n = 298). Relative risk (RR) for weight gain during ET was highest in women who were premenopausal (RR = 1.29, 1.03–1.52) and had Stage 3 BC (RR = 2.12, 1.59–2.82), mastectomy (RR = 1.49, 1.19–1.88), axillary node dissection (RR = 1.39, 1.11–1.73), and chemotherapy (RR = 1.80, 1.37–2.36). For each kg of weight gained between BC diagnosis and start of ET, and for each additional year of age, RR of gaining weight during ET decreased (RR = 0.98, 0.97–0.99, and RR = 0.99, 0.98–0.99, respectively). Menopausal status and type of ET were not significant predictors of weight gain. In multivariable analysis, only weight loss between BC diagnosis and start of ET was significant. Conclusion: The association of weight loss prior to ET and subsequent substantial weight gain during ET warrants further investigation.
Dynamic structure factor and drag force in a one-dimensional strongly-interacting Bose gas at finite temperature
Creators: name: Lang, Guillaume
name: Hekking, Frank
name: Minguzzi, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the effect of thermal and quantum fluctuations on the dynamical response of a one-dimensional strongly-interacting Bose gas in a tight atomic waveguide. We combine the Luttinger liquid theory at arbitrary interactions and the exact Bose-Fermi mapping in the Tonks-Girardeau-impenetrable-boson limit to obtain the dynamic structure factor of the strongly-interacting fluid at finite temperature. Then, we determine the drag force felt by a potential barrier moving along the fluid in the experimentally realistic situation of finite barrier width and temperature.
description: 13 pages, 11 figures
Temperature Control of Stirred Tank Heater using Optimal Control Technique
Creators: name: Mustefa Jibril
name: Messay Tadese
name: Eliyas Alemayehu
Publisher: name: figshare
Year: 2020
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents the application of optimal control problem in modeling of stirred tank heater
temperature control. The analysis of the open loop system shows that the system is not efficient without a controller.
Linear Quadratic Gaussian (LQG) and Linear Quadratic Integral (LQI) controllers are used to increase the
performance of the system. Comparison of the closed loop system with the proposed controllers have been done
with Matlab/Simulink Toolbox and a promising results have been analyzed.
АНАЛИТИЧЕСКИЙ УЧЕТ МАТЕРИАЛЬНО-ПРОИЗВОДСТВЕННЫХ ЗАПАСОВ
Creators: name: И. В. Дрожжина
name: С. В. Кириллова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: материальные запасы
аналитический учет
отклонение
материальная ценность.

description: В статье дается определение материально-производственных запасов их видов при производстве товаров и услуг, рассматривается методика аналитического учета материалов для учета и анализа. Целью анализа состоит в том, что ведение аналитического учета сегодня имеет большое значение, так как влияет на экономический потенциал организации и эффективность работы. Ведь бесперебойная работа позволяет производить больше продукции, минимизируя риск остановки производства, повышая эффективность работы.
Light Emission from Ag(111) driven by Inelastic Tunneling in the Field Emission Regime
Creators: name: Martínez-Blanco, Jesús
name: Fölsch, Stefan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the light emission from a Ag(111) surface when the bias voltage on a scanning tunneling microscope (STM) junction is ramped into the field emission regime. Above the vacuum level, scanning tunneling spectroscopy (STS) shows a series of well defined resonances associated with the image states of the surface, which are Stark shifted due to the electric field provided by the STM tip. We present photon--energy resolved measurements that unambiguously show that the mechanism for light emission is the radiative decay of surface localized plasmons excited by the electrons that tunnel inelastically into the Stark shifted image states. Our work illustrates the effect of the tip radius both in the STS spectrum and the light emission maps by repeating the experiment with different tips.
description: 11 pages, 3 figures
Influence of provider factors and race on uptake of breast cancer gene expression profiling
Creators: name: Wheeler, S.B.
name: Meng, K.
name: Reeder-Hayes, K.E.
name: Carey, L.A.
name: Zhou, X.
name: Baggett, C.D.
name: Meyer, A.-M.
name: Roberts, M.C.
Publisher: name: John Wiley and Sons Inc.
Year: 2018

description: BACKGROUND: Gene expression profiling (GEP) has been rapidly adopted for early breast cancer and can aid in chemotherapy decision making. Study results regarding racial disparities in testing are conflicting, and may reflect different care settings. To the authors' knowledge, data regarding the influence of provider factors on testing are scarce. METHODS: The authors used a statewide, multipayer, insurance claims database linked to cancer registry records to examine the impact of race and provider characteristics on GEP uptake in a cohort of patients newly diagnosed with breast cancer between 2005 and 2012. Incidence proportion models were used to examine the adjusted likelihood of testing. Models were stratified by lymph node status (N0 vs N1). RESULTS: Among 11,958 eligible patients, 23% of black and 26% of non-Hispanic white patients received GEP. Among patients with N0 disease, black individuals were 16% less likely to receive testing after adjustment for clinical factors and the provider's specialty and volume of patients with breast cancer (95% confidence interval, 0.77-0.93). Adjustment for provider characteristics did not attenuate the effect of race on testing. Patients of middle-volume providers were more likely to be tested compared with those with either high-volume or low-volume providers, whereas patients seeing a medical oncologist were more likely to be tested compared with those whose only providers were from surgical specialties. CONCLUSIONS: Provider volume and specialty were found to be significant predictors of GEP use, but did not explain racial disparities in testing. Further research concerning the key contributors to lagging test use among black women is needed to optimize the equitable use of GEPs and support personalized treatment decision making for all patients.
PAM50 and risk of recurrence scores for interval breast cancers
Creators: name: Olshan, A.F.
name: Kuzmiak, C.M.
name: Henderson, L.M.
name: Puvanesarajah, S.
name: Tse, C.-K.
name: Allott, E.H.
name: Carey, L.A.
name: Troester, M.A.
name: Chen, M.
name: Nyante, S.J.
name: Perou, C.M.
name: Sun, X.
name: Kirk, E.L.
Publisher: name: American Association for Cancer Research Inc.
Year: 2018

description: Breast cancers detected after a negative breast screening examination and prior to the next screening are referred to as interval cancers. These cancers generally have poor clinical characteristics compared with screen-detected cancers, but associations between interval cancer and genomic cancer characteristics are not well understood. Mammographically screened women diagnosed with primary invasive breast cancer from 1993 to 2013 (n ¼ 370) were identified by linking the Carolina Breast Cancer Study and the Carolina Mammography Registry. Among women with a registry-identified screening mammogram 0 to 24 months before diagnosis, cancers were classified as screen-detected (N ¼ 165) or interval-detected (N ¼ 205). Using logistic regression, we examined the association of mode of detection with cancer characteristics (clinical, IHC, and genomic), overall, and in analyses stratified on mammographic density and race. Interval cancer was associated with large tumors [>2 cm; OR, 2.3; 95% confidence interval (CI), 1.5–3.7], positive nodal status (OR, 1.8; 95% CI, 1.1–2.8), and triple-negative subtype (OR, 2.5; 95% CI, 1.1–5.5). Interval cancers were more likely to have non-Luminal A subtype (OR, 2.9; 95% CI, 1.5–5.7), whereas screen-detected cancers tended to be more indolent (96% had low risk of recurrence genomic scores; 71% were PAM50 Luminal A). When stratifying by mammographic density and race, associations between interval detection and poor prognostic features were similar by race and density status. Strong associations between interval cancers and poor-prognosis genomic features (non-Luminal A subtype and high risk of recurrence score) suggest that aggressive tumor biology is an important contributor to interval cancer rates.
МЕРЫ ГОСУДАРСТВЕННОЙ ПОДДЕРЖКИ РАЗВИТИЯ МОЛОДЕЖНОГО РЫНКА ТРУДА
Creators: name: Е. Б. Дуплинская
name: М. В. Рыльская
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: молодежный рынок труда
государственная политика занятости молодежи
государственное регулирование рынка труда
безработица

description: В статье рассмотрены вопросы государственного регулирования молодежного рынка труда на региональном уровне. Определена сущность молодежного рынка труда, а также рассмотрены государственные программы как инструменты реализации государственной политики развития молодежного рынка труда. Установлено, что в современных условиях развития региональной экономики, проблема трудоустройства выпускников остается одной из актуальных. Несмотря на реализуемые меры господдержки развития молодежного рынка труда, выпускники высших учебных заведений продолжают сталкиваться с проблемами при трудоустройстве по специальности, что свидетельствует о недостаточном уровне эффективности государственных мер.
Visualizing the chiral anomaly in Dirac and Weyl semimetals with photoemission spectroscopy
Creators: name: Behrends, Jan
name: Grushin, Adolfo G.
name: Ojanen, Teemu
name: Bardarson, Jens H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Quantum anomalies are the breaking of a classical symmetry by quantum fluctuations. They dictate how physical systems of diverse nature, ranging from fundamental particles to crystalline materials, respond topologically to external perturbations, insensitive to local details. The anomaly paradigm was triggered by the discovery of the chiral anomaly that contributes to the decay of pions into photons and influences the motion of superfluid vortices in $^3$He-A. In the solid state, it also fundamentally affects the properties of topological Weyl and Dirac semimetals, recently realized experimentally in TaAs, Na$_3$Bi, Cd$_3$As$_2$, and ZrTe$_{5}$. In this work we propose that the most identifying consequence of the chiral anomaly, the charge density imbalance between fermions of different chirality induced by non-orthogonal electric and magnetic fields, can be directly observed in these materials with the existing technology of photoemission spectroscopy. With angle resolution, the chiral anomaly is identified by a characteristic note-shaped pattern of the emission spectra, originating from the imbalanced occupation of the bulk states and a previously unreported momentum dependent energy shift of the surface state Fermi arcs. We further demonstrate that the chiral anomaly likewise leaves an imprint in angle averaged emission spectra, facilitating its experimental detection. Thereby, our work provides essential theoretical input to foster the direct visualization of the chiral anomaly in condensed matter.
description: 5+4 pages, 6 Figures, 1 Table, extended discussion and appendix
Optimal source-sink matching and prospective hub-cluster configurations for CO2 capture and storage in India
Creators: name: Vishal, Vikram
name: Singh, Udayan
name: Bakshi, Tuli
name: Chandra, Debanjan
name: Verma, Yashvardhan
name: Tiwari, Ashwani Kumar
Publisher: name: Geological Society of London
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Distance of each LPS from Euclidian center of sinks in each cluster along with their type and annual emission.
Deep Reinforcement Learning for Power Control in Next-Generation WiFi Network Systems
Creators: name: Jamous, Ziad El
name: Davaslioglu, Kemal
name: Sagduyu, Yalin E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Machine Learning (cs.LG)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents a deep reinforcement learning (DRL) solution for power control in wireless communications, describes its embedded implementation with WiFi transceivers for a WiFi network system, and evaluates the performance with high-fidelity emulation tests. In a multi-hop wireless network, each mobile node measures its link quality and signal strength, and controls its transmit power. As a model-free solution, reinforcement learning allows nodes to adapt their actions by observing the states and maximize their cumulative rewards over time. For each node, the state consists of transmit power, link quality and signal strength; the action adjusts the transmit power; and the reward combines energy efficiency (throughput normalized by energy consumption) and penalty of changing the transmit power. As the state space is large, Q-learning is hard to implement on embedded platforms with limited memory and processing power. By approximating the Q-values with a DQN, DRL is implemented for the embedded platform of each node combining an ARM processor and a WiFi transceiver for 802.11n. Controllable and repeatable emulation tests are performed by inducing realistic channel effects on RF signals. Performance comparison with benchmark schemes of fixed and myopic power allocations shows that power control with DRL provides major improvements to energy efficiency and throughput in WiFi network systems.
description: 5 pages, 6 figures, 1 table
ЭКОНОМИЧЕСКАЯ ОЦЕНКА ПРОИЗВОДСТВА КЛУБНЕЙ КАРТОФЕЛЯ СОРТОВ ОТЕЧЕСТВЕННОЙ СЕЛЕКЦИИ
Creators: name: С. В. Жаркова
name: С. С. Новикова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: картофель
урожайность
затраты
экономическая эффективность
рентабельность.

description: В статье представлены результаты оценки экономической эффективности возделывания сортов картофеля отечественной селекции. Для исследования были взяты шесть сортов картофеля разных групп спелости. Минимальный показатель себестоимости продукции отмечен у сорта Невский – стандарт и составил 2324,8 руб./т. Себестоимость продукции исследуемых сортов превысила показатель стандарта на 30,1-55,2%. Максимальная прибыль получена у сортов раннеспелой группы: Невский – 281146,4 руб./га и Лина – 182636,4 руб./га. В результате расчётов экономической эффективности было установлено, что возделывание сортов картофеля рентабельно
Spontaneously established syntrophic yeast communities improve bioproduction.
Creators: name: Aulakh, Simran Kaur
name: Vidal, Lara Sellés
name: South, Eric J
name: Peng, Huadong
name: Varma, Sreejith Jayasree
name: Herrera-Dominguez, Lucia
name: Ralser, Markus
name: Ledesma-Amaro, Rodrigo
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Synthetic Biology
Chemical Biology & High Throughput
Ecology,Evolution & Ethology
Metabolism
Computational & Systems Biology

description: Nutritional codependence (syntrophy) has underexplored potential to improve biotechnological processes by using cooperating cell types. So far, design of yeast syntrophic communities has required extensive genetic manipulation, as the co-inoculation of most eukaryotic microbial auxotrophs does not result in cooperative growth. Here we employ high-throughput phenotypic screening to systematically test pairwise combinations of auxotrophic Saccharomyces cerevisiae deletion mutants. Although most coculture pairs do not enter syntrophic growth, we identify 49 pairs that spontaneously form syntrophic, synergistic communities. We characterized the stability and growth dynamics of nine cocultures and demonstrated that a pair of tryptophan auxotrophs grow by exchanging a pathway intermediate rather than end products. We then introduced a malonic semialdehyde biosynthesis pathway split between different pairs of auxotrophs, which resulted in increased production. Our results report the spontaneous formation of stable syntrophy in S. cerevisiae auxotrophs and illustrate the biotechnological potential of dividing labor in a cooperating intraspecies community.
Reliability, Informativeness and Sensitivity in dark matter observation
Creators: name: Antoniou, Antonis
Publisher: name: Zenodo
Year: 2022
Subjects: dark matter, observation, informativeness, model sensitivity, reliability

description: The systematic research of dark matter spans more than five decades, however, the exact nature of dark matter still remains elusive. In this talk, a useful framework for the epistemology of dark matter observation will be provided via a conceptual analysis of the five main methods of dark matter observation. Based on the epistemic virtues of these methods with respect to their informativeness, model sensitivity and reliability, it will be argued that a partial explanation for the lack of progress in dark matter research possibly comes from the important limitations of robustness arguments from the variability of experiments in this field. The discussion will close with `the puzzle of dark matter observation’, namely, the fact that the only possible way to collect reliable results that will narrow down the range of viable candidate dark matter models is by presupposing these models.
A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer
Creators: name: Reeder-Hayes, K.
name: Kornblum, Z.A.
name: Weck, K.E.
name: Phipps, R.
name: Perou, C.M.
name: Anders, C.K.
name: Hu, Z.
name: Marcom, P.K.
name: Zamboni, W.C.
name: Carey, L.A.
name: Dees, E.C.
name: McRee, A.J.
name: Moore, D.T.
Publisher: name: Elsevier Inc.
Year: 2018

description: We report the results from a phase I study of buparlisib, an oral pan-class I phosphotidyinositol-3-kinase inhibitor, combined with capecitabine in patients with metastatic breast cancer. The maximum tolerated dose of the combination was buparlisib 100 mg daily and capecitabine 1000 mg/m 2 twice daily. A complete response was seen in 1 patient with a basal-like tumor. Pharmacokinetic analysis suggested that a pharmacokinetic interaction might exist between the 2 agents. Background: Buparlisib is an oral pan-class I phosphotidyinositol-3-kinase (PI3K) inhibitor. The present phase I study evaluated the safety, pharmacokinetics, and efficacy of buparlisib with capecitabine in patients with metastatic breast cancer. Patients and Methods: Patients received buparlisib once daily (range, 50 to 100 mg) for 3 weeks with capecitabine twice daily (range, 1000 to 1250 mg/m 2 ) for 2 weeks with a 1-week break. Dose escalation used a traditional “3 + 3” design with standard definitions of dose-limiting toxicity (DLT) and maximum tolerated dose. Results: Of the 25 patients enrolled, 23 were evaluable for DLT and 17 were evaluable for response. The maximum tolerated dose of the combination was buparlisib 100 mg daily and capecitabine 1000 mg/m 2 twice daily. DLTs included grade 3 hyperglycemia and grade 3 confusion. The most common grade 3 toxicities were diarrhea and elevation of aspartate aminotransferase and alanine transaminase. One patient exhibited a complete response to treatment and four had a confirmed partial response. In cohorts 3 and 4, in which the buparlisib dose remained constant but the capecitabine dose was increased, significant increases in the buparlisib plasma concentration were noted. Conclusion: The combination of buparlisib with capecitabine in patients with metastatic breast cancer was generally well-tolerated, with several patients demonstrating prolonged responses. Unexpectedly low rates of PIK3CA mutations (3 of 17) were seen, and only 2 of 7 tumors with subtyping were luminal, making exploration of these putative predictive markers impossible. Further study of the combination is not unreasonable, with expanded pharmacokinetics and sequencing analysis to better elucidate potential drug–drug interactions and more accurate predictive biomarkers of response.
Changing Natural History of HER2–Positive Breast Cancer Metastatic to the Brain in the Era of New Targeted Therapies
Creators: name: Keith, K.C.
name: Deal, A.M.
name: Zagar, T.
name: Ewend, M.G.
name: Shachar, S.S.
name: Dees, E.C.
name: Benbow, J.M.
name: Anders, C.K.
name: Mounsey, L.A.
name: Carey, L.A.
Publisher: name: Elsevier Inc.
Year: 2018

description: Patients with breast cancer brain metastases historically have a poor prognosis. In this single-institution cohort study of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases, we found no improvement in survival after brain recurrence over time despite wide adoption of HER2–targeted therapies. This highlights the importance of continued development of novel brain penetrant therapies for patients with HER2–positive metastatic disease to extend survival and improve quality of life. Background: Given the wide adoption of human epidermal growth factor receptor 2 (HER2)-targeted therapies for advanced HER2–positive breast cancer, we studied the natural history of patients with HER2–positive breast cancer brain metastases (BCBM) over time. Patients and Methods: Patients with HER2–positive BCBM identified from a prospectively maintained database at the University of North Carolina were divided into 3 cohorts by year of BCBM diagnosis. Cohorts were selected by year of HER2–targeted therapy US Food and Drug Administration approval. Overall survival (OS), time to first metastasis, time to BCBM, and BCBM survival were estimated by the Kaplan-Meier method. Associations between OS after BCBM and clinical variables were assessed by Cox proportional hazards regression models. Results: One hundred twenty-three patients were identified. Median age was 51 years, and 58% were white and 31% African American. OS from initial breast cancer diagnosis improved over time: 3.6 years (95% confidence interval [CI], 2.8-6.1) in the 1998-2007 cohort, 6.6 years (95% CI, 4.5-8.6) in the 2008-2012 cohort, and 7.6 years (95% CI, 4.4-9.6) in the 2013-2015 cohort (P =.05). While time from initial diagnosis to first metastasis did not differ (P =.12), time to BCBM increased over time (2.6 years [95% CI, 1.3-3.5] for 1998-2007; 2.6 years [95% CI, 2.1-4.3] for 2008-2012, and 3.3 years [95% CI, 2.2-6] for 2013-2015; P =.05). Although OS from BCBM did not significantly differ by cohort, patients who received HER2–targeted therapy after BCBM had a prolonged OS (2.1 years [95% CI, 1.6-2.6] vs. 0.65 years [95% CI, 0.4-1.3]; P =.001). Conclusion: OS from initial breast cancer diagnosis significantly improved over time for patients with HER2–positive breast cancer who develop BCBM, now exceeding 7 years; survival from BCBM diagnosis may now exceed 2 years.
Role of layer packing for the electronic properties of the organic superconductor (BEDT-TTF)$_2$Ag(CF$_3$)$_4$(TCE)
Creators: name: Altmeyer, Michaela
name: Valenti, Roser
name: Jeschke, Harald O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The charge transfer compound (BEDT-TTF)$_2$Ag(CF$_3$)$_4$(TCE) crystallizes in three polymorphs with different alternating layers: While a phase with a $κ$ packing motif has a low superconducting transition temperature of $T_c=2.6$ K, two phases with higher $T_c$ of $9.5$ and $11$ K are multi-layered structures consisting of $α'$ and $κ$ layers. We investigate these three systems within density functional theory and find that the $α'$ layer shows different degrees of charge order for the two $κ$-$α'$ systems and directly influences the electronic behavior of the conducting $κ$ layer. We discuss the origin of the distinct behavior of the three polymorphs and propose a minimal tight-binding Hamiltonian for the description of these systems based on projective molecular Wannier functions.
description: 8 pages, 12 figures
Financial impact of breast cancer in black versus white women
Creators: name: Spencer, J.C.
name: Reeder-Hayes, K.E.
name: Wheeler, S.B.
name: Olshan, A.F.
name: Carey, L.A.
name: Pinheiro, L.C.
Publisher: name: American Society of Clinical Oncology
Year: 2018

description: Purpose Racial variation in the financial impact of cancer may contribute to observed differences in the use of guideline-recommended treatments. We describe racial differences with regard to the financial impact of breast cancer in a large population-based prospective cohort study. Methods The Carolina Breast Cancer Study oversampled black women and women younger than age 50 years with incident breast cancer in North Carolina from 2008 to 2013. Participants provided medical records and data regarding demographics, socioeconomic status, and financial impact of cancer at 5 and 25 months postdiagnosis. We report unadjusted and adjusted financial impact at 25 months postdiagnosis by race. Results The sample included 2,494 women who completed follow-up surveys (49% black, 51% white). Since diagnosis, 58% of black women reported any adverse financial impact of cancer (v 39% of white women; P, .001). In models adjusted for age, stage at diagnosis, and treatment received, black women were more likely to report adverse financial impact attributable to cancer (adjusted risk difference [aRD], +14 percentage points; P, .001), including income loss (aRD, +10 percentage points; P, .001), health care–related financial barriers (aRD, +10 percentage points; P, .001), health care–related transportation barriers (aRD, +10 percentage points; P, .001), job loss (aRD, 6 percentage points; P, .001), and loss of health insurance (aRD, +3 percentage points; P, .001). The effect of race was attenuated when socioeconomic factors were included but remained significant for job loss, transportation barriers, income loss, and overall financial impact. Conclusion Compared with white women, black women with breast cancer experience a significantly worse financial impact. Disproportionate financial strain may contribute to higher stress, lower treatment compliance, and worse outcomes by race. Policies that help to limit the effect of cancer-related financial strain are needed.
ПРИЧИНЫ И ПОСЛЕДСТВИЯ ВОЗНИКНОВЕНИЯ ДВОЙНОГО НАЛОГООБЛОЖЕНИЯ ДОХОДОВ ПРЕДСТАВИТЕЛЕЙ ИНДУСТРИИ РАЗВЛЕЧЕНИЙ И СПОРТА ОТ МЕЖДУНАРОДНОЙ ДЕЯТЕЛЬНОСТИ
Creators: name: Ю. А. Исаева
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: налогообложение артистов и спортсменов
выступающих на международном уровне
налогообложение артистов и спортсменов нерезидентов
двойное налогообложение доходов
налоговый кредит
налоговая система на основе резидентства
глобальный принцип налогообложения

description: Для представителей индустрии развлечений и спорта проблема международного двойного налогообложения остается одним из существенных препятствий в их международной профессиональной деятельности, в силу применения к их доходам, возникшим от профессиональной деятельности в других странах специальных международных правил налогообложения. Эти правила предоставляют странам источникам права на налогообложение доходов от спортивной и развлекательной деятельности, возникших на их территории. Данная статья представляет комплексное исследование условий, приводящих к возникновению чрезмерного налогового бремени в отношении налогообложения доходов рассматриваемой группы налогоплательщиков. Автор дает оценку причин применения специальных национальных налоговых правил в отношении таких налогоплательщиков, последствий их применения и потенциал для смягчения негативных последствий.
Mechanically Actuated Capacitor Microphone Control using MPC and NARMA-L2 Controllers
Creators: name: Mustefa Jibril
name: Messay Tadese
name: Eliyas Alemayehu
Publisher: name: figshare
Year: 2020
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, a capacitor microphone system is presented to improve the conversion of mechanical energy
to electrical energy using a nonlinear auto regressive moving average-L2 (NARMA-L2) and model predictive
control (MPC) controllers for the analysis of the open loop and closed loop system. The open loop system response
shows that the output voltage signal need to be improved. The comparison of the closed loop system with the
proposed controllers have been analyzed and a promising result have been obtained using Matlab/Simulink.
Tracking plasma DNA mutation dynamics in estrogen receptor positive metastatic breast cancer with dPCR-SEQ
Creators: name: Anders, C.K.
name: Carey, L.A.
name: Gupta, G.P.
name: Lindsay, D.
name: Tan, X.M.
name: Kumar, S.
name: Chen, Q.B.
name: Garrett, A.L.
Publisher: name: Nature Publishing Group
Year: 2018

description: Serial monitoring of plasma DNA mutations in estrogen receptor positive metastatic breast cancer (ER + MBC) holds promise as an early predictor of therapeutic response. Here, we developed dPCR-SEQ, a customized assay that utilizes digital PCR-based target enrichment followed by next-generation sequencing to analyze plasma DNA mutations in ESR1, PIK3CA, and TP53. We validated dPCR-SEQ in a prospective cohort of 58 patients with ER + MBC and demonstrate excellent concordance with hotspot ESR1 mutation abundance measured by conventional digital PCR. The dPCR-SEQ assay revealed ESR1, PIK3CA, and TP53 plasma ctDNA mutations in 55%, 32%, and 32% of the study patients, respectively. We also observed dynamic changes in ESR1, PIK3CA, and TP53 ctDNA mutant allele fraction (MAF) that were frequently discordant between the different genes. Thus, monitoring plasma DNA mutation dynamics using a dPCR-SEQ assay is feasible, accurate, and may be investigated as a biomarker of therapeutic response in ER + MBC.
An assessment of prognostic immunity markers in breast cancer
Creators: name: Shi, Y.
name: Kaufmann, W.
name: Chou, J.
name: Hu, Z.
name: Li, X.
name: Wu, D.
name: Zhou, T.
name: Li, Y.
name: Chu, Y.
name: Wu, J.
name: Tang, F.
name: Tao, Y.
name: Yang, B.
name: Wu, X.
name: Carey, L.A.
name: Ma, L.
Publisher: name: Nature Publishing Group
Year: 2018

description: Tumor-infiltrating lymphocytes (TIL) and immunity gene signatures have been reported to be significantly prognostic in breast cancer but have not yet been applied for calculation of risk of recurrence in clinical assays. A compact set of 17 immunity genes was derived herein from an Affymetrix-derived gene expression dataset including 1951 patients (AFFY1951). The 17 immunity genes demonstrated significant prognostic stratification of estrogen receptor (ER)-negative breast cancer patients with high proliferation gene expression. Further analysis of blood and breast cancer single-cell RNA-seq datasets revealed that the 17 immunity genes were derived from TIL that were inactive in the blood and became active in tumor tissue. Expression of the 17 immunity genes was significantly (p < 2.2E-16, n = 91) correlated with TILs percentage on H&E in triple negative breast cancer. To demonstrate the impact of tumor immunity genes on prognosis, we built a Cox model to incorporate breast cancer subtypes, proliferation score and immunity score (72 gene panel) with significant prediction of outcomes (p < 0.0001, n = 1951). The 72 gene panel and its risk evaluation model were validated in two other published gene expression datasets including Illumina beads array data METABRIC (p < 0.0001, n = 1997) and whole transcriptomic mRNA-seq data TCGA (p = 0.00019, n = 996) and in our own targeted RNA-seq data TARGETSEQ (p < 0.0001, n = 303). Further examination of the 72 gene panel in single cell RNA-seq of tumors demonstrated tumor heterogeneity with more than two subtypes observed in each tumor. In conclusion, immunity gene expression was an important parameter for prognosis and should be incorporated into current multi-gene assays to improve assessment of risk of distant metastasis in breast cancer.
Design & Control of Vehicle Boom Barrier Gate System using Augmented H2 Optimal & H infinity Synthesis Controllers
Creators: name: Mustefa Jibril
name: Messay Tadese
name: Tesfabirhan Shoga
Publisher: name: figshare
Year: 2020
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: A vehicle boom barrier gate system is one of the recently developed technologies operating at the
entrances to the restricted areas. This paper aims to design and control of vehicle’s boom barrier gate system using
robust augmentation technique. 2 H optimal and H  synthesis controllers are used to improve the performance of
the system. The open loop response analysis of the vehicle boom barrier gate system shows that the input of the
system need to be improved. Comparison of the vehicle boom barrier gate system with 2 H optimal and H 
synthesis controllers have been done to track a set point desired angular position using a step and operational open
and close input signals and a promising results have been observed.
К ВОПРОСУ О ПОРЯДКЕ ПЕРЕСЧЕТА ИНОСТРАННОЙ ВАЛЮТЫ ПРИ ОТСУТСТВИИ ЕЕ ОФИЦИАЛЬНОГО КУРСА
Creators: name: Е. В. Карпунина
name: А. Ю. Карпунин
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: кросс-курс
валютная пара
прямая котировка
обратная котировка
иностранная валюта
курс иностранной валюты

description: В статье рассмотрены отдельные вопросы, касающиеся порядка пересчета иностранной валюты при отсутствии ее официального курса. Особое внимание уделено базе данных по курсам валют, представленной на сайте ЦБ РФ. Рассмотрены способы расчета кросс-курса валют с использованием прямых и одновременно прямых и обратных валютных пар. Определено, что содержание изменения, внесенного в абзац 1 пункта 5 ПБУ 3/2006, касающееся пересчёта иностранных валют, официальные курсы которых не установлены Банком России, должно быть уточнено.
ПРОБЛЕМЫ ОРГАНИЗАЦИИ ОБЩЕСТВЕННОГО КОНТРОЛЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: М. А. Кессиди
name: Н. В. Лоскутов
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: общественный контроль
субъекты общественного контроля
объекты общественного контроля
общественная палата
независимость общественного контроля.

description: В статье анализируются: научная литература и действующее законодательство. Этот анализ помог выявить некоторые проблемы организации общественного контроля в Российской Федерации. Анализ показал, что данные проблемы, препятствуют формированию и внедрению общественного контроля за деятельностью органов власти. Определены возможные варианты решения обнаруженных проблем в сфере организации общественного контроля. Решение данных проблем поможет добиться соблюдения прав и свобод человека и обеспечит повышение эффективности и прозрачности деятельности органов государственной власти.
Preliminary study of the high-frequency instability of an aerospike rocket engine
Creators: name:  F. ROSSI
name:   O. NIKOLAYEV
name:   I. BASHLIY
name:   R. MARCHAN
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: PROPULSION PHYSICS
LIQUID ROCKET ENGINE
COMBUSTION INSTABILITIES

description: A demonstrator aerospike engine, developed by Pangea Aerospace, has a thrust of 2 metric tons and features a toroidal (annular) combustion chamber powered by liquid oxygen and liquid methane. Predicting the parameters of high-frequency processes of the engine chamber, issuing recommendations to ensure engine performance, high-frequency stability and dynamic strength of its structure, monitoring and analyzing the technical condition of the engine during testing are all important topics to be addressed before conducting static fire tests of the engine. A mathematical model of a coupled shell structure with an annular configuration gas dynamic system for the engine with a toroidal combustion chamber has been developed. Based on the model, the preliminary predictive computations of the shapes and frequencies of natural oscillations have been performed, as well as computations of the amplitude of stresses and displacements of the combustion chamber structure under resonant excitation of this dynamic system. The results of such evaluations can ultimately be useful in ensuring the structural strength of the engine combustion chamber. The natural oscillation modes of shell structure with an annular configuration gas dynamic system, obtained from the analysis of the results of mathematical modeling, are due to the manifestation of natural acoustic properties of the chamber cavity, taking into account the influence of the combustion chamber structure. The results of theoretical studies are summarized and preliminary recommendations are formulated to increase the stability of the combustion chamber to possible high-frequency oscillations based on design measures (baffles, absorbers and parameter adjusting of the engine injectors).
МИФЫ И РЕАЛЬНОСТЬ ВНУТРЕННЕГО АУДИТА НА ПРИМЕРЕ КОМПАНИЙ НЕФТЕГАЗОВОГО СЕКТОРА
Creators: name: Л. В. Ким
name: А. Д. Егорова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: внутренний аудит
мифы и реальность
система управления рисками
Сахалинская область
Сахалин Энерджи
нефтегазовые компании
понятие внутреннего аудита
внутренний контроль

description: В данной работе рассматривается опровержение мифов внутреннего аудита, на примере аудита в нефтегазовом секторе. Актуальность исследования мифов и реальности внутреннего аудита заключается в том, что большинству предприятий необходимо понимать важность и сущность аудита для использования на его на практике и обеспечения более эффективной деятельности компании. Внутренний аудит является довольно значимой и важной категорией в развитии бизнеса. Любое крупное предприятие в обязательном порядке должно иметь подразделение внутреннего аудита, а профессионализм работников данной области должен быть прямо пропорционален рискам, присущим деятельности Компании. В работе было выявлено, что основными мифами внутреннего аудита зачастую становятся: наличие в компаниях единственного основного внутреннего аудитора, проверка в основном нацелена на бухгалтерскую отчетность, аудит необходим для выявления нарушений и применения карательных санкций.