cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations
Creators: name: Akpa, Chidimma Agatha
name: Kleo, Karsten
name: Lenze, Dido
name: Oker, Elisabeth
name: Dimitrova, Lora
name: Hummel, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: DZNep
subject: Burkittlymphoma
subject: apoptosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Enhancer of zeste homolog 2 (EZH2) tri-methylates histone 3 at position lysine 27 (H3K27me3). Overexpression and gain-of-function mutations in EZH2 are regarded as oncogenic drivers in lymphoma and other malignancies due to the silencing of tumor suppressors and differentiation genes. EZH2 inhibition is sought to represent a good strategy for tumor therapy. In this study, we treated Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) cell lines with 3-deazaneplanocin-A (DZNep), an indirect EZH2 inhibitor which possesses anticancer properties both in-vitro and in-vivo. We aimed to address the impact of the lymphoma type, EZH2 mutation status, as well as MYC, BCL2 and BCL6 translocations on the sensitivity of the lymphoma cell lines to DZNep-mediated apoptosis. We show that DZNep inhibits proliferation and induces apoptosis of these cell lines independent of the type of lymphoma, the EZH2 mutation status and the MYC, BCL2 and BCL6 rearrangement status. Furthermore, DZNep induced a much stronger apoptosis in majority of these cell lines at a lower concentration, and within a shorter period when compared with EPZ-6438, a direct EZH2 inhibitor currently in phase II clinical trials. Apoptosis induction by DZNep was both concentration-dependent and time-dependent, and was associated with the inhibition of EZH2 and subsequent downregulation of H3K27me3 in DZNep-sensitive cell lines. Although EZH2, MYC, BCL2 and BCL6 are important prognostic biomarkers for lymphomas, our study shows that they poorly influence the sensitivity of lymphoma cell lines to DZNep-mediated apoptosis.
Amenable Discrete Quantum Groups
Creators: name: Tomatsu, Reiji
Publisher: name: arXiv
Year: 2003
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 46L65

description: Z.-J. Ruan has shown that several amenability conditions are all equivalent in the case of discrete Kac algebras. In this paper, we extend this work to the case of discrete quantum groups. That is, we show that a discrete quantum group, where we do not assume its unimodularity, has an invariant mean if and only if it is strongly Voiculescu amenable.
description: 16 pages, minor corrections
Cheumatopsyche langsonina Navas 1933
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche langsonina

description: Cheumatopsyche langsonina Navás, 1933
 Cheumatopsyche langsonina Navás, 1933: 98.
 Type locality: Vietnam.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 159
A Novel Combination of Soluplus®/Poloxamer for Meloxicam Solid Dispersions via Hot Melt Extrusion for Rapid Onset of Action. Part 2: Comparative Bioavailability and IVIVC
Creators: name: Taha, Nesrin F.
name: Emam, Maha F.
name: Emara, Laila H.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Objective: Bioavailability of Meloxicam (MLX) from solid dispersions (SDs), against innovator product Mobic® in humans was conducted. Furthermore, to establish a good in vitro-in vivo correlation (IVIVC); dissolution studies were carried-out in different media. Methods: MLX/SDs was prepared using Soluplus/Poloxamer via hot-melt-extrusion (EXT-SD) and fusion melt (FUS-SD) techniques. A single oral dose (15 mg), three periods, crossover study of MLX/SDs and Mobic® in 4 healthy humans under fed conditions was carried-out. In vitro dissolution was studied in pH 1.2, distilled water (pH 6.4) and biorelevant simulated gastric media in pre- and post-prandial states. Level A IVIVC was carried-out by comparing time-scaled fraction dissolved versus fraction absorbed, calculated using the Wagner-Nelson method. Multiple level C models were developed for Cmax and AUC0-96 versus % dissolved at different time-points. Internal predictability was evaluated for both IVIVC models. Results: MLX rate of absorption (Tmax) from EXT-SD, FUS-SD and Mobic® were 1.5, 3.0 and 4.0 h, respectively. Moreover, 1.45 - and 1.40 – folds increase in AUC0-∞ and Cmax, was obtained for EXT-SD versus Mobic®, respectively, while FUS-SD gave the lowest extent of drug absorption. EXT-SD provided highest dissolution profiles in all studied media. IVIVC models showed linear-regression (R2 ≥ 0.90) and prediction errors (≤ 10%) in water and post-prandial simulated gastric media. Conclusion: Hot-melt-extrusion technology promises an ideal alternative for enhancing MLX extent of absorption compared to Mobic® with Tmax value almost equal to the reported intramuscular injection. Predictive IVIVC was established for in vitro dissolution profile and in vivo performance.
Additional file 3 of Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
Creators: name: Lindner, Paula
name: Christensen, Søren
name: Nissen, Poul
name: Møller, Jesper
name: Engedal, Nikolai
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 2: Figure S7. LC3B is partially required for Tg-induced cell death, and LC3B depletion does not increase DR5 protein levels. Figure S8. Tg-induced cell death does not require the key autophagic membrane components ATG5, FIP200, or GABARAPs. Figure S9. Tg-induced cell death depends on PERK, ATF4 and CHOP in HCT116 cells.
The effect of an anomalous Higgs trilinear self-coupling on the h to gamma Z decay
Creators: name: Degrassi, G.
name: Vitti, M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We compute the two-loop effects induced by an anomalous Higgs trilinear self-coupling in the partial decay width h to gamma Z. The computation is performed using the anomalous coupling approach working in the unitary gauge and in a theory in which the anomalous coupling is generated via the addition to the scalar potential part of the Standard Model Lagrangian of an (in)finite tower of (Phi^dagger Phi)^n terms. The former computation is automatically finite while the latter requires the renormalization of the lowest order contribution. We discuss the renormalization conditions that should be employed in order to obtain the same result in the two approaches. We find that the h to gamma Z process is one of the most sensitive mode to an anomalous trilinear Higgs self-coupling. As a by-product of this work we confirm one of two different results present in the literature concerning the contribution of an anomalous Higgs trilinear coupling in the h to gamma gamma decay.
description: 17 pages, 5 figures
Adjuvant radiotherapy improves progression-free survival in intracranial atypical meningioma
Creators: name: Hemmati, Saman Moritz
name: Ghadjar, Pirus
name: Grün, Arne
name: Badakhshi, Harun
name: Zschaeck, Sebastian
name: Senger, Carolin
name: Acker, Güliz
name: Misch, Martin
name: Budach, Volker
name: Kaul, David
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Adjuvant radiotherapy
subject: Atypical meningioma
subject: Fractionated stereotactic radiotherapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Meningiomas are the most common primary tumors of the central nervous system. In patients with WHO grade I meningiomas no adjuvant therapy is recommended after resection. In case of anaplastic meningiomas (WHO grade III), adjuvant fractionated radiotherapy is generally recommended, regardless of the extent of surgical resection. For atypical meningiomas (WHO grade II) optimal postoperative management has not been clearly defined yet. METHODS: We conducted a retrospective analysis of patients treated for intracranial atypical meningioma at Charité Universitätsmedizin Berlin from March 1999 to October 2018. Considering the individual circumstances (risk of recurrence, anatomical location, etc.), patients were either advised to follow a wait-and-see approach or to undergo adjuvant radiotherapy. Primary endpoint was progression-free survival (PFS). RESULTS: This analysis included 99 patients with atypical meningioma (WHO grade II). Nineteen patients received adjuvant RT after primary tumor resection (intervention group). The remaining 80 patients did not receive any further adjuvant therapy after surgical resection (control group). Median follow-up was 37 months. Median PFS after primary resection was significantly longer in the intervention group than in the control group (64 m vs. 37 m, p = 0.009, HR = 0.204, 95% CI = 0.062-0.668). The influence of adjuvant RT was confirmed in multivariable analysis (p = 0.041, HR = 0.192, 95% CI = 0.039-0.932). CONCLUSIONS: Our study adds to the evidence that RT can improve PFS in patients with atypical meningioma.
Jet Deflection via Cross winds: Laboratory Astrophysical Studies
Creators: name: Lebedev, S. . V.
name: Ampleford, D.
name: Ciardi, A.
name: Bland, S. N.
name: Chittenden, J. P.
name: Haines, M. G.
name: Frank, A.
name: Blackman, E. G.
name: Cunningham, A.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present new data from High Energy Density (HED) laboratory experiments designed to explore the interaction of a heavy hypersonic radiative jet with a cross wind. The jets are generated with the MAGPIE pulsed power machine where converging conical plasma flows are produced from a cylindrically symmetric array of inclined wires. Radiative hypersonic jets emerge from the convergence point. The cross wind is generated by ablation of a plastic foil via soft-X-rays from the plasma convergence region. Our experiments show that the jets are deflected by the action of the cross wind with the angle of deflection dependent on the proximity of the foil. Shocks within the jet beam are apparent in the data. Analysis of the data shows that the interaction of the jet and cross wind is collisional and therefore in the hydro-dynamic regime. MHD plasma code simulations of the experiments are able to recover the deflection behaviour seen in the experiments. We consider the astrophysical relevance of these experiments applying published models of jet deflection developed for AGN and YSOs. Fitting the observed jet deflections to quadratic trajectories predicted by these models allows us to recover a set of plasma parameters consistent with the data. We also present results of 3-D numerical simulations of jet deflection using a new astrophysical Adaptive Mesh Refinement code. These simulations show highly structured shocks occurring within the beam similar to what was observed in the experiments
description: Submitted to ApJ. For a version with figures go to http://web.pas.rochester.edu/~afrank/labastro/CW/Jet-Wind-Frank.pdf
Additional file 2 of Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
Creators: name: Lindner, Paula
name: Christensen, Søren
name: Nissen, Poul
name: Møller, Jesper
name: Engedal, Nikolai
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. Chemical structures of drugs used in the current study. (a) Tg and the Tg analogs 8-O-debutanoyl-8-O-N-L-Leucinoyl-12-aminododecanoylthapsigargin (Leu-8ADT) and 8-O-debutanoyl-8-O-N-L-b-aspartoyl-12-aminododecanoylthapsigargin (βAsp-8ADT) (b) The PERK inhibitor GSK2606414 (c) the JNK inhibitor JNK-IN-8. Figure S2. Tg-induced cell death depends on DR5 and caspase-8, but not DR4, Fas, FADD, or TRADD in HCT116 cells. Figure S3. Quantification of DR5 protein levels (related to Fig. 1 and Fig. S2). Figure S4. DR4, TRADD and Fas knockdown confirmations (related to Fig. 1 and Fig. S2). Figure S5. Tg-induced cell death does not require TRAIL. Figure S6. DR5 and caspase-8 are strongly required for Tg-induced cell in both LNCaP and HCT116 cells (related to Fig. 1 and Fig. S2).
A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line
Creators: name: Genov, Nikolai
name: Basti, Alireza
name: Abreu, Mónica
name: Astaburuaga, Rosario
name: Relógio, Angela
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: splicing factors
subject: HD-MY-Z
subject: circadian clock
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock in the regulation of post-transcriptional processes, including splicing, remains poorly understood. In the present work, we investigated the putative interplay between the circadian clock and splicing in a cancer context. For this, we applied a computational pipeline to identify oscillating genes and alternatively spliced transcripts in time-course high-throughput data sets from normal cells and tissues, and cancer cell lines. We investigated the temporal phenotype of clock-controlled genes and splicing factors, and evaluated their impact in alternative splice patterns in the Hodgkin Lymphoma cell line HD-MY-Z. Our data points to a connection between clock-controlled genes and splicing factors, which correlates with temporal alternative splicing in several genes in the HD-MY-Z cell line. These include the genes DPYD, SS18, VIPR1 and IRF4, involved in metabolism, cell cycle, apoptosis and proliferation. Our results highlight a role for the clock as a temporal regulator of alternative splicing, which may impact malignancy in this cellular model.
Additional file 1 of The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells
Creators: name: Ellison, Marshall
name: Mittal, Mukul
name: Minu Chaudhuri
name: Chaudhuri, Gautam
name: Misra, Smita
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 1: Table S1. Sequences of the oligonucleotides used in this study. Figure S1. SLUG is needed for the silencer mediated repression of BRCA2 gene promoter in SLUG-positive BT549 cells. Figure S2. Dividing cells have higher oxidation state compared to no-dividing (quiescent). Figure S3. Protein translated from the splice variant PRDX5A is the only stable form. Figure S4. Mitochondrial localization signal is enough to take the protein to mitochondria. Figure S5. Nuclear localization signal is enough to take the protein to the nucleus.
Comparing physicians' and patients' reporting on adverse reactions in randomized trials on acupuncture-a secondary data analysis
Creators: name: Schwaneberg, Thea
name: Witt, Claudia M.
name: Roll, Stephanie
name: Pach, Daniel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Acupuncture
subject: Adverse reaction
subject: Safety documentation
subject: Patients’ reports
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: We aimed to compare patients' and physicians' safety reporting using data from large acupuncture trials (44,818 patients) and to determine associations between patient characteristics and reporting of adverse reactions. METHODS: Six pragmatic randomized trials with an additional non-randomized study arm that included those patients who refused randomization were evaluated. Patients received acupuncture treatment for osteoarthritis of the hip or knee, chronic neck pain, chronic low back pain, chronic headache, dysmenorrhea, or allergic rhinitis or asthma. Safety outcomes were evaluated by questionnaires from both the physicians and the patients. To determine level of agreement between physicians and patients on the prevalence of adverse reactions, Cohen's kappa was used. With multilevel models associations between patient characteristics and reporting of adverse reactions were assessed. RESULTS: Patients reported on average three times more adverse reactions than the study physicians: for bleeding/haematoma, 6.7% of patients (n = 2458) vs. 0.6% of physicians (n = 255) and for pain, 1.7% of patients (n = 636) vs. 0.5% of physicians (n = 207). We found only minor agreements between patients and physicians (maximum Cohen's kappa: 0.50, 95% confidence interval [0.49;0.51] for depressive mood). Being a female and participation in the randomization were associated with higher odds of reporting an adverse reaction. CONCLUSIONS: In our study, patients' and physicians' reports on adverse reactions of acupuncture differed substantially, possibly due to differences in patients' and physicians' questionnaires and definitions. For the assessment of safety, we strongly support the inclusion of patients' and physicians' reports while ensuring standardization of data collection and definitions.
Cheumatopsyche japonica
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche japonica

description: Cheumatopsyche japonica (Navás, 1916)
 Hydropsychodes japonica Navás, 1916: 87.
 Cheumatopsyche japonica (Navás, 1916); Kimmins 1963: 130.
 Type locality: Japan.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 159
A posteriori error analysis of a local adaptive discontinuous Galerkin method for convection-diffusion-reaction equations
Creators: name: Abdulle, Assyr
name: de Souza, Giacomo Rosilho
Publisher: name: arXiv
Year: 2020
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N15, 65N30

description: We introduce a local adaptive discontinuous Galerkin method for convection-diffusion-reaction equations. The proposed method is based on a coarse grid and iteratively improves the solution's accuracy by solving local elliptic problems in refined subdomains. For purely diffusion problems, we already proved that this scheme converges under minimal regularity assumptions [A. Abdulle and G.Rosilho de Souza, ESAIM: M2AN, 53(4):1269--1303, 2019]. In this paper, we provide an algorithm for the automatic identification of the local elliptic problems' subdomains employing a flux reconstruction strategy. Reliable error estimators are derived for the local adaptive method. Numerical comparisons with a classical nonlocal adaptive algorithm illustrate the efficiency of the method.
Inhibitory effect on ovarian cancer ALDH+ stem-like cells by Disulfiram and Copper treatment through ALDH and ROS modulation
Creators: name: Guo, Fang
name: Yang, Zhi
name: Kulbe, Hagen
name: Albers, Andreas E.
name: Sehouli, Jalid
name: Kaufmann, Andreas M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Adjuvant chemotherapy
subject: ALDH enzyme activity
subject: Cellular apoptosis
subject: Cytotoxicity
subject: Novel chemotherapeutic agent
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Disulfiram (DSF) is a drug used for treatment of alcoholism that has also displayed promising anti-cancer activity. It unfolds its effects by inhibiting the enzyme activity of aldehyde dehydrogenase (ALDH) isoforms. METHODS: MTT assay, spheroid formation, clonogenicity assay, qRT-PCR, and ALDH enzyme activity analysis were performed using ovarian cancer cell lines IGROV1, SKOV3 and SKOV3IP1. Cell cycle analyses and measurement of intracellular reactive oxygen species (ROS) were carried out by flow cytometry. ALDH+ and ALDH- cells were isolated by FACS sorting. RESULTS: ALDH activity was inhibited in ovarian cancer stem cells (the proportion of ALDH+ cells was reduced from 21.7% to 0.391%, 8.4% to 0%, 6.88% to 0.05% in cell lines IGROV1, SKOV3, and SKOV3IP1, respectively). DSF with or without the cofactor copper (Cu2+) exhibited cytotoxicity dose- and time-dependent and enhanced cisplatin-induced apoptosis. DSF + Cu2+ increased intracellular ROS levels triggering apoptosis of ovarian cancer stem cells (CSC). Significantly more colony and spheroid formation was observed in ALDH+ compared with ALDH- cells (P
Can Microlensing Explain the Long-Term Optical Variability of Quasars?
Creators: name: Zackrisson, Erik
name: Bergvall, Nils
name: Marquart, Thomas
name: Helbig, Phillip
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Although controversial, the scenario of microlensing as the dominant mechanism for the long-term optical variability of quasars does provide a natural explanation for both the statistical symmetry, achromaticity and lack of cosmological time dilation in quasar light curves. Here, we investigate to what extent dark matter populations of compact objects allowed in the currently favored Omega_M=0.3, Omega_Lambda=0.7 cosmology really can explain the quantitative statistical features of the observed variability. We find that microlensing reasonably well reproduces the average structure function of quasars, but fails to explain both the high fraction of objects with amplitudes higher than 0.35 magnitudes and the mean amplitudes observed at redshifts below one. Even though microlensing may still contribute to the long-term optical variability at some level, another significant mechanism must also be involved. This severely complicates the task of using light-curve statistics from quasars which are not multiply imaged to isolate properties of any cosmologically significant population of compact objects which may in fact be present.
description: 9 pages, 7 figures, accepted for publication in A&A
Magnetic helicity budget of solar active regions prolific of eruptive and confined flares
Creators: name: Thalmann, J. K.
name: Moraitis, K.
name: Linan, L.
name: Pariat, E.
name: Valori, G.
name: Dalmasse, K.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We compare the coronal magnetic energy and helicity of two solar active regions (ARs), prolific in major eruptive (AR~11158) and confined (AR~12192) flaring, and analyze the potential of deduced proxies to forecast upcoming flares. Based on nonlinear force-free (NLFF) coronal magnetic field models with a high degree of solenoidality, and applying three different computational methods to investigate the coronal magnetic helicity, we are able to draw conclusions with a high level of confidence. Based on real observations of two solar ARs we checked trends regarding the potential eruptivity of the active-region corona, as suggested earlier in works that were based on numerical simulations, or solar observations. Our results support that the ratio of current-carrying to total helicity, $|H_\mathrm{J}|/|H_\mathrm{V}|$, shows a strong ability to indicate the eruptive potential of a solar AR. However, $|H_\mathrm{J}|/|H_\mathrm{V}|$ seems not to be indicative for the magnitude or type of an upcoming flare (confined or eruptive). Interpreted in context with earlier observational studies, our findings furthermore support that the total relative helicity normalized to the magnetic flux at the NLFF model's lower boundary, $H_\mathrm{V}/ϕ^2$, represents no indicator for the eruptivity.
description: 11 pages, 3 figures, accepted for publication in ApJ
Benchmarking computer platforms for lattice QCD applications
Creators: name: Hasenbusch, M.
name: Jansen, K.
name: Pleiter, D.
name: St"uben, H.
name: Wegner, P.
name: Wettig, T.
name: Wittig, H.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We define a benchmark suite for lattice QCD and report on benchmark results from several computer platforms. The platforms considered are apeNEXT, CRAY T3E, Hitachi SR8000, IBM p690, PC-Clusters, and QCDOC.
description: 3 pages, Lattice03, machines and algorithms
A sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison
Creators: name: De Campos, Débora Priscila
name: Neila Márcia Silva-Barcellos
name: Marinho, Flávia Dias Marques
name: Barbosa, Guilherme Xavier
name: Victória Luiza Vieira Vidigal Lana
name: De Souza, Jacqueline
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Donepezil hydrochloride is one of the most prescribed anti-Alzheimer’s drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions in vivo (pH 1.2, 4.5, and 6.8) are not available in the literature. These media are used in the dissolution test, an important tool, for registration and quality control of medicines. Considering the need for methods with this purpose, this work aimed to develop and validate a sustainable UPLC-UV method for quantification of donepezil hydrochloride in tablets, specifically on assay and dissolution profile, with reduced environmental impacts. The proposed method has a run time of 2 min and requires for each run, only 0.8 mL of solvents, providing excellent green analysis. The method proved to be selective, linear, precise, accurate, robust in the range of 2–14 µg/mL. Three products (reference, similar, and generic) were analyzed and showed very rapid dissolution. The average content varied from 100.2 ± 0.6% to 109.5 ± 2.1%. Using dissolution efficiency (DE), the drug release profiles were compared in different biorelevant media.
Fig (Ficus carica L.) leaf tea suppresses allergy by acceleration disassembly of IgE-receptor complexes
Creators: name: Abe, Tatsuya
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: In this study, I investigated the allergy suppressive effect of tea made from fig (Ficus carica L.) leaves. In the rat basophil cell line RBL-2H3, degranulation was significantly suppressed by treatment with fig tea at the same time as addition of IgE antibodies (sensitization). IgE bound to the cell surface was liberated in the medium depending on the treatment time with fig tea. Therefore, it was suggested that the mechanism of action of fig tea is promotion of dissociation of IgE from FcεRI receptors. Such a mechanism is novel in food materials. On oral administration to mice, fig tea showed an inhibitory effect on allergic dermatitis. Furthermore, in tests using an atopic dermatitis model in NC/Nga mice, continued administration of fig tea suppressed symptom exacerbation after antigen administration. AD: atopic dermatitis; β-Hex: β-hexosaminidase; FCM: flow cytometory; OA: oral administration; TA: transdermal administration Scheme of suppression allergy by fig tea
Low-momentum interaction in few-nucleon systems
Creators: name: Nogga, Andreas
name: Bogner, Scott K.
name: Schwenk, Achim
Publisher: name: arXiv
Year: 2004
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The effective low-momentum interaction Vlowk is applied to three- and four-nucleon systems. We investigate the 3H, 3He and 4He binding energies for a wide range of the momentum cutoffs. By construction, all low-energy two-body observables are cutoff-independent, and therefore, any cutoff dependence is due to missing three-body or higher-body forces. We argue that for reasonable cutoffs Vlowk is similar to high-order interactions derived from chiral effective field theory. This motivates augmenting Vlowk by corresponding three-nucleon forces. The set of low-momentum twoand three-nucleon forces can be used in calculations of nuclear structure and reactions.
description: 4 pages, 4 figures
Additional file 1 of Functional characterization of the soybean cyst nematode effector SCN-27D09 using the model plant pathogenic fungus Magnaporthe oryzae-mediated delivery system
Creators: name: Yang, Nan
name: Yu, Qianqian
name: Li, Wenhao
name: Chen, Deng
name: Jian, Jinzhuo
name: Zhang, Huixia
name: Wang, Gaofeng
name: Liu, Shiming
name: Huang, Wenkun
name: Peng, Huan
name: Peng, Deliang
name: Yang, Jun
name: Guo, Xiaoli
name: Kong, Lingan
Publisher: name: figshare
Year: 2022
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Amino acid sequence alignment of 27D09 and the other four putative effectors in SCN. Figure S2. PCR verification of pRP27-mCherryNLS and pRP27-SCN-27D09-mCherryNLS transformants. Figure S3. PCR verification of pRP27-GFP and pRP27-SCN-27D09-GFP transformants. Figure S4. Multiple sequence alignment and phylogenetic analysis of IPK and its homologous proteins in soybean and Arabidopsis thaliana.
Subthreshold photoproduction of charm
Creators: name: Braun, M. A.
name: Vlahovic, B.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Charm photoproduction rates off nuclei below the nucleon threshold are estimated using the phenomenologically known structure functions both for x>1 and x<1. The rates rapidly fall below the threshold from values of the order 10 pb for Pb close to the threshold (at 7.5 GeV) down to values of the order 1 pb at 6 GeV.
description: 11 p[ages, 7 figures
Non-Hermitian Interactions Between Harmonic Oscillators, with Applications to Stable, Lorentz-Violating QED
Creators: name: Altschul, B.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine a new application of the Holstein-Primakoff realization of the simple harmonic oscillator Hamiltonian. This involves the use of infinite-dimensional representations of the Lie algebra $su(2)$. The representations contain nonstandard raising and lowering operators, which are nonlinearly related to the standard $a^†$ and $a$. The new operators also give rise to a natural family of two-oscillator couplings. These nonlinear couplings are not generally self-adjoint, but their low-energy limits are self-adjoint, exactly solvable, and stable. We discuss the structure of a theory involving these couplings. Such a theory might have as its ultra-low-energy limit a Lorentz-violating Abelian gauge theory, and we discuss the extremely strong astrophysical constraints on such a model.
description: 11 pages
Topological crystalline insulator state with type-II Dirac fermions in transition metal dipnictides
Creators: name: Wang, Baokai
name: Singh, Bahadur
name: Ghosh, Barun
name: Chiu, Wei-Chi
name: Hosen, M. Mofazzel
name: Zhang, Qitao
name: Ying, Li
name: Neupane, Madhab
name: Agarwal, Amit
name: Lin, Hsin
name: Bansil, Arun
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The interplay between topology and crystalline symmetries in materials can lead to a variety of topological crystalline insulator (TCI) states. Despite significant effort towards their experimental realization, so far only Pb$_{1-x}$Sn$_x$Te has been confirmed as a mirror-symmetry protected TCI. Here, based on first-principles calculations combined with a symmetry analysis, we identify a rotational-symmetry protected TCI state in the transition-metal dipnictide RX$_2$ family, where R = Ta or Nb and X = P, As, or Sb. Taking TaAs$_2$ as an exemplar system, we show that its low-energy band structure consists of two types of bulk nodal lines in the absence of spin-orbit coupling (SOC) effects. Turning on the SOC opens a continuous bandgap in the energy spectrum and drives the system into a $C_2T$-symmetry-protected TCI state. On the (010) surface, we show the presence of rotational-symmetry-protected nontrivial Dirac cone states within a local bulk energy gap of $\sim$ 300 meV. Interestingly, the Dirac cones have tilted energy dispersion, realizing a type-II Dirac fermion state in a topological crystalline insulator. Our results thus indicate that the TaAs$_2$ materials family provides an ideal setting for exploring the unique physics associated with type-II Dirac fermions in rotational-symmetry-protected TCIs.
description: 7 pages, 7 figures, Accepted for publication in Physical Review B (2019)
TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells
Creators: name: Benzing, Christian
name: Lam, Hoyin
name: Tsang, Chi Man
name: Rimmer, Alexander
name: Arroyo-Berdugo, Yoana
name: Calle, Yolanda
name: Wells, Claire M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Pancreatic ductal adenocarcinoma
subject: Monocytes
subject: Tumor microenvironment
subject: TIMP2
subject: Invadopodia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invasion have not been fully established. METHODS: To specifically test the impact of interaction on invasive potential two PDAC cell lines PaTu8902 and CFPAC-1 were selected on their ability to form invasive adhesions, otherwise known as invadopodia and invade in a spheroid invasion assay. RESULTS: Interestingly when the PDAC cells were co-cultured with undifferentiated THP1 monocyte-like cells invadopodia formation was significantly suppressed. Moreover, conditioned media of THP1 cells (CM) was also able to suppress invadopodia formation. Further investigation revealed that both tissue inhibitor of metalloproteinase (TIMP) 1 and 2 were present in the CM. However, suppression of invadopodia formation was found that was specific to TIMP2 activity. CONCLUSIONS: Our findings indicate that TIMP2 levels in the tumour microenvironment may have prognostic value in patients with PDAC. Furthermore, activation of TIMP2 expressing monocytes in the primary tumour could present a potential therapeutic opportunity to suppress cell invasion in PDAC.
The termination shock in a striped pulsar wind
Creators: name: Lyubarsky, Y. E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The origin of radio emission from plerions is considered. Recent observations suggest that radio emitting electrons are presently accelerated rather than having been injected at early stages of the plerion evolution. The observed flat spectra without a low frequency cutoff imply an acceleration mechanism that raises the average particle energy by few orders of magnitude but leaves most of the particles at the energy less than about few hundred MeV. It is suggested that annihilation of the alternating magnetic field at the pulsar wind termination shock provides the necessary mechanism. Toroidal stripes of opposite magnetic polarity are formed in the wind emanated from an obliquely rotating pulsar magnetosphere (the striped wind). At the termination shock, the flow is compressed and the magnetic field annihilates by driven reconnection. Jump conditions are obtained for the shock in a striped wind. It is shown that postshock MHD parameters of the flow are the same as if the energy of alternating field has already been converted into the plasma energy upstream the shock. Therefore the available estimates of the ratio of the Poynting flux to the matter energy flux, $σ$, should be attributed not to the total upstream Poynting flux but only to that associated with the average magnetic field. A simple model for the particle acceleration in the shocked striped wind is presented.
description: 9 pages, 2 figures, accepted MNRAS
Impacts of Solar Intermittency on Future Photovoltaic Reliability
Creators: name: Yin, Jun
name: Molini, Annalisa
name: Porporato, Amilcare
Publisher: name: arXiv
Year: 2020
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: As photovoltaic power is expanding rapidly worldwide, it is imperative to assess its promise under future climate scenarios. While a great deal of research has been devoted to trends of mean solar radiation, less attention has been paid to its intermittent character, a key challenge when compounded with uncertainties related to climate variability. Using both satellite data and climate model outputs, here we characterize solar radiation intermittency to assess future photovoltaic reliability. We find that the relation between the future power supply and long-term trends of mean solar radiation is highly nonlinear, thus making power reliability more sensitive to the fluctuations of mean solar radiation in regions where insolation is the highest. Our results highlight how reliability analysis must account simultaneously for the mean and intermittency of solar inputs when assessing the impacts of climate change on photovoltaics.
description: 19 pages, 10 figures, 1 table
Does Telemedical Support of First Responders Improve Guideline Adherence in an Offshore Emergency Scenario? A Simulator-Based Prospective Study
Creators: name: Landgraf, Philipp
name: Spies, Claudia
name: Lawatscheck, Robert
name: Luz, Maria
name: Wernecke, Klaus-Dieter
name: Schröder, Torsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: emergency first response
subject: offshore safety
subject: simulation
subject: teleconsultation
subject: telemedicine
subject: telepresence
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: OBJECTIVE: To investigate, in a simulator-based prospective study, whether telemedical support improves quality of emergency first response (performance) by medical non-professionals to being non-inferior to medical professionals. SETTING: In a simulated offshore wind power plant, duos (teams) of offshore engineers and teams of paramedics conducted the primary survey of a simulated patient. PARTICIPANTS: 38 offshore engineers and 34 paramedics were recruited by the general email invitation. INTERVENTION: Teams (randomised by lot) were supported by transmission technology and a remote emergency physician in Berlin. OUTCOME MEASURES: From video recordings, performance (17 item checklist) and required time (up to 15 min) were quantified by expert rating for analysis. Differences were analysed using two-sided exact Mann-Whitney U tests for independent measures, non-inferiority was analysed using Schuirmann one-sided test. The significance level of 5 % was Holm-Bonferroni adjusted in each family of pairwise comparisons. RESULTS: Nine teams of engineers with, nine without, nine teams of paramedics with and eight without support completed the task. Two experts quantified endpoints, insights into rater dependence were gained. Supported engineers outperformed unsupported engineers (p<0.01), insufficient evidence was found for paramedics (p=0.11). Without support, paramedics outperformed engineers (p<0.01). Supported engineers' performance was non-inferior (at one item margin) to that by unsupported paramedics (p=0.03). Supported groups were slower than unsupported groups (p<0.01). CONCLUSIONS: First response to medical emergencies in offshore wind farms with substantially delayed professional care may be improved by telemedical support. Future work should test our result during additional scenarios and explore interdisciplinary and ecosystem aspects of this support. TRIAL REGISTRATION NUMBER: DRKS00014372
Neutralino dark matter in supergravity theories with non-universal scalar and gaugino masses
Creators: name: Cerdeno, D. G.
name: Munoz, C.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyse the direct detection of neutralino dark matter in supergravity scenarios with non-universal soft scalar and gaugino masses. In particular, the neutralino-nucleon cross section is computed and compared with the sensitivity of detectors. We take into account the most recent experimental and astrophysical constraints on the parameter space, including those coming from charge and colour breaking minima. Gaugino non-universalities provide a larger flexibility in the neutralino sector. In particular, when combined with non-universal scalars, neutralinos close to the present detection limits are possible with a wide range of masses, from over 400 GeV to almost 10 GeV. We study the different possibilities which allow to increase or decrease the neutralino mass and explain the properties of those regions in the parameter space with a large cross section.
description: 32 pages, 18 figures. Final version to appear in JHEP
Cheumatopsyche madagassa
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche madagassa

description: Cheumatopsyche madagassa (Navás, 1923)
 Hydropsychodes madagassa Navás, 1923: 27.
 Cheumatopsyche madagassa (Navás, 1923); Kimmins 1963: 130.
 Type locality: Madagascar.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 159
Synthetic observations of internal gravity waves in the solar atmosphere
Creators: name: Vigeesh, G.
name: Roth, M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We study the properties of internal gravity waves (IGWs) detected in synthetic observations that are obtained from realistic numerical simulation of the solar atmosphere. We used four different simulations of the solar magneto-convection performed using the CO5BOLD code. A magnetic-field-free model and three magnetic models were simulated. The latter three models start with an initial vertical, homogeneous field of 10, 50, and 100 G magnetic flux density, representing different regions of the quiet solar surface. We used the NICOLE code to compute synthetic spectral maps from all the simulated models for the two magnetically insensitive neutral iron lines Fe I 5434 Å and 5576 Å. We find the signatures of the internal gravity waves in the synthetic spectra to be consistent with observations of the real Sun. The phase differences obtained using the spectral lines are significantly different from the phase differences in the simulation. The phase coherency between two atmospheric layers in the gravity wave regime is height dependent and is seen to decrease with the travel distance between the observed layers. We conclude that the energy flux of IGWs determined from the phase difference analysis may be overestimated by an order of magnitude. Spectral lines that are weak and less temperature sensitive may be better suited to detecting internal waves and accurately determining their energy flux in the solar atmosphere.
description: To appear in Astronomy & Astrophysics, 12 pages, 12 figures, abridged abstract
Turmeric/oregano formulations for treatment of diabetic ulcer wounds
Creators: name: Sami, Diana G.
name: Abdellatif, Ahmed
name: Azzazy, Hassan M. E.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Diabetic wound infections and pressure ulcers pose a significant challenge to healthcare providers worldwide. The current study provides new and innovative wound care products that reduce inflammation, clear infection, and improve healing in an animal model of pressure ulcers in diabetic rats. Ointment, hydrogel, and nanofiber dressings were synthesized using 5% turmeric, 1% oregano, and 1% chitosan nanoparticles and tested for antibacterial and cytotoxicity in vitro, and wound healing effects in vivo. Turmeric ethanolic extract showed high antioxidant activity compared to Oregano, Chitosan Nanoparticles, and Alginate silver (p-value < 0.0001). The ointment and hydrogel formulation (5% Turmeric, 1% Oregano, and 1% chitosan) showed lower cytotoxicity compared to the commercial Alginate silver dressing. Ointment, hydrogel formulations, and commercial Alginate silver, showed significant antibacterial activity with 100% efficacy on both Staphylococcus aureus and Escherichia coli (p-value < 0.0001), compared to nanofibers which showed 50% reduction in bacterial growth (p-value < 0.0001). The new formulations were tested in a rat model of pressure ulcers. Ointment and nanofibers achieved complete wound healing by day 15 compared to the hydrogel and commercial Alginate silver dressing, which showed higher infection, and the wound remained partially open by day 21. In conclusion, Turmeric, Oregano extracts, and chitosan nanoparticles can be used for effective wound dressings in both diabetic and non-diabetic wounds. At relatively low concentrations, this combination provides a promising new wound treatment formulation that is antibacterial, anti-inflammatory, and antioxidant.