cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma.
Creators: name: Booth, Stephen W
name: Eyre, Toby A
name: Whittaker, John
name: Campo, Leticia
name: Wang, Lai Mun
name: Soilleux, Elizabeth
name: Royston, Daniel
name: Rees, Gabrielle
name: Kesavan, Murali
name: Hildyard, Catherine
name: Kazmi, Farasat
name: La Thangue, Nick
name: Kerr, David
name: Middleton, Mark R
name: Collins, Graham P
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Biomarker
Lymphoma
Histone Deacetylase (Hdac)
Hr23b

description: BackgroundThis Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients with relapsed / refractory lymphoma or advanced solid organ cancers and to assess HR23B protein expression by immunohistochemistry as a biomarker of HDAC inhibitor sensitivity.MethodsPatients with advanced solid-organ cancers with high HR23B expression or lymphomas received CXD101 at the recommended phase 2 dose (RP2D). Key exclusions: corrected QT > 450 ms, neutrophils 9/L, platelets 9/L, ECOG > 1. Baseline HR23B expression was assessed by immunohistochemistry.ResultsFifty-one patients enrolled between March 2014 and September 2019, 47 received CXD101 (19 solid-organ cancer, 28 lymphoma). Thirty-four patients received ≥80% RP2D. Baseline characteristics: median age 57.4 years, median prior lines 3, male sex 57%. The most common grade 3-4 adverse events were neutropenia (32%), thrombocytopenia (17%), anaemia (13%), and fatigue (9%) with no deaths on CXD101. No responses were seen in solid-organ cancers, with disease stabilisation in 36% or patients; the overall response rate in lymphoma was 17% with disease stabilisation in 52% of patients. Median progression-free survival was 1.2 months (95% confidence interval (CI) 1.2-5.4) in solid-organ cancers and 2.6 months (95%CI 1.2-5.6) in lymphomas. HR23B status did not predict response.ConclusionsCXD101 showed acceptable tolerability with efficacy seen in Hodgkin lymphoma, T-cell lymphoma and follicular lymphoma. Further studies assessing combination approaches are warranted.Trial registrationClinicalTrials.gov identifier NCT01977638 . Registered 07 November 2013.
The impact of gas flows on galaxy scaling relations
Creators: name: Langan, Ivanna
Publisher: name: Zenodo
Year: 2023

description: Gas flows play a major role in the evolution of galaxies, but measuring both the gas flow rates and the properties of galaxies (e.g., stellar mass, metallicity and SFR) remains challenging. Using MgII quasar absorption observations of the MusE GAs FLOw and Wind (MEGAFLOW) survey, we have, for the first time, directly constrained gas flows and galaxy properties at z = 0.35-1.4. In this talk, I will present our self-consistent study of the impact of gas flows on key scaling relations, namely the main sequence, the mass-metallicity relation and the fundamental metallicity relation. In particular, we find that the scatter around these scaling relations are driven by long timescales (several hundreds of Myr) fluctuations. I will place these findings in the context of gas-regulator models and discuss why our work implies that larger and more diverse samples of galaxies with simultaneous measurements of gas-phase metallicities and gas flows are critical to understand galaxy evolution.
Solenoidal Lipschitz truncation for parabolic PDE's
Creators: name: Breit, D.
name: Diening, L.
name: Schwarzacher, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 76B03, 35D05, 35J60, 26B35

description: We consider functions $u\in L^\infty(L^2)\cap L^p(W^{1,p})$ with $1
Proximity effects in spin-triplet superconductor-ferromagnet heterostucture with spin-active interface
Creators: name: Terrade, Damien
name: Gentile, Paola
name: Cuoco, Mario
name: Manske, Dirk
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the physical properties of a ballistic heterostructure made of a ferromagnet (FM) and a spin-triplet superconductor (TSC) with a layered structure stacking along the direction perpendicular to the planes where a chiral px+ipy pairing occurs and assuming spin dependent processes at the interface. We use a self-consistent Bogoliubov-de Gennes approach on a three-dimensional lattice to obtain the spatial profiles of the pairing amplitude and the magnetization. We find that, depending on the strength of the ferromagnetic exchange field, the ground state of the system can have two distinct configurations with a parallel or anti-parallel collinearity between the magnetic moments in the bulk and at the interface. We demonstrate that a magnetic state having non coplanar interface, bulk and Cooper pairs spins may be stabilized if the bulk magnetization is assumed to be fixed along a given direction. The study of the density of states reveals that the modification of the electronic spectrum in the FM plays an important role in the setting of the optimal magnetic configuration. Finally, we find the existence of induced spin-polarized pair correlations in the FM-TSC system.
description: 15 pages, 11 figures
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals.
Creators: name: Thillaiappan, Nagendra Babu
name: Smith, Holly A
name: Atakpa-Adaji, Peace
name: Taylor, Colin W
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Hela Cells
Cytosol
Animals
Humans
Calcium
Microfilament Proteins
Actins
Membrane Proteins
Microscopy, Fluorescence
RNA Interference
Protein Binding
Inositol 1,4,5-Trisphosphate Receptors
HEK293 Cells

description: Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile IP3Rs, yet Ca2+ puffs occur at a few immobile IP3R clusters. By imaging cells with endogenous IP3Rs tagged with EGFP, we show that KRas-induced actin-interacting protein (KRAP) tethers IP3Rs to actin beneath the plasma membrane. Loss of KRAP abolishes Ca2+ puffs and the global increases in cytosolic Ca2+ concentration evoked by more intense stimulation. Over-expressing KRAP immobilizes additional IP3R clusters and results in more Ca2+ puffs and larger global Ca2+ signals. Endogenous KRAP determines which IP3Rs will respond: it tethers IP3R clusters to actin alongside sites where store-operated Ca2+ entry occurs, licenses IP3Rs to evoke Ca2+ puffs and global cytosolic Ca2+ signals, implicates the actin cytoskeleton in IP3R regulation and may allow local activation of Ca2+ entry.
Hierarchical Liouville-space approach for accurate and universal characterization of quantum impurity systems
Creators: name: Li, ZhenHua
name: Tong, NingHua
name: Zheng, Xiao
name: Hou, Dong
name: Wei, JianHua
name: Hu, Jie
name: Yan, YiJing
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: A hierarchical equations of motion (HEOM) based numerical approach is developed for accurate and efficient evaluation of dynamical observables of strongly correlated quantum impurity systems. This approach is capable of describing quantitatively Kondo resonance and Fermi liquid characteristics, achieving the accuracy of latest high-level numerical renormalization group approach, as demonstrated on single-impurity Anderson model systems. Its application to a two-impurity Anderson model results in differential conductance versus external bias, which correctly reproduces the continuous transition from Kondo states of individual impurity to singlet spin-states formed between two impurities. The outstanding performance on characterizing both equilibrium and nonequilibrium properties of quantum impurity systems makes the HEOM approach potentially useful for addressing strongly correlated lattice systems in the frame work of dynamical mean field theory.
description: 5 pages, 4 figures, to appear in PRL
Engelbert Winter, Die sāsānidisch-römischen Friedensverträge des 3. Jahrhunderts n. Chr. Ein Beitrag zum Verständnis der außenpolitischen Beziehungen zwischen den beiden Großmächten
Creators: name: Brockmeier, Beate
Publisher: name: Bonner Jahrbücher
Year: 2019

description: Rezension zu: Engelbert Winter, Die sāsānidisch-römischen Friedensverträge des 3. Jahrhunderts n. Chr. Ein Beitrag zum Verständnis der außenpolitischen Beziehungen zwischen den beiden Großmächten. Europäische Hochschulschriften, Reihe 3, Geschichte und ihre Hilfswissenschaften, Band 350. Verlag Peter Lang, Frankfurt 1988. 344 Seiten.
description: Bonner Jahrbücher, Bd. 191.1991(1992): Bonner Jahrbücher
Conformally invariant thermodynamics of a Maxwell-Dilaton black hole
Creators: name: Lopez-Monsalvo, C S
name: Nettel, F
name: Quevedo, H
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The thermodynamics of Maxwell-Dilaton (dirty) black holes has been extensively studied. It has served as a fertile ground to test ideas about temperature through various definitions of surface gravity. In this paper, we make an independent analysis of this black hole solution in both, Einstein and Jordan, frames. We explore a set of definitions for the surface gravity and observe the different predictions they make for the near extremal configuration of this black hole. Finally, motivated by the singularity structure in the interior of the event horizon, we use a holographic argument to remove the micro-states from the disconnected region of this solution. In this manner, we construct a frame independent entropy from which we obtain a temperature which agrees with the standard results in the non-extremal regime, and has a desirable behaviour around the extremal configurations according to the third law of black hole mechanics.
description: amendments from the previous version
Lu Tran Tieu, Palaeolithic Pebble Industries in Europe
Creators: name: Fiedler, Lutz
Publisher: name: Bonner Jahrbücher
Year: 2019

description: Rezension zu: Lu Tran Tieu, Palaeolithic Pebble Industries in Europe. Akadémiai Kiadó, Budapest 1991. 109 Seiten, 13 Textabbildungen, 33 Tafeln.
description: Bonner Jahrbücher, Bd. 193.1993(1994): Bonner Jahrbücher
Atmospheric dynamics of brown dwarfs and directly imaged giant planets
Creators: name: Showman, Adam P.
name: Kaspi, Yohai
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A variety of observations provide evidence for vigorous motion in the atmospheres of brown dwarfs and directly imaged giant planets. Motivated by these observations, we examine the dynamical regime of the circulation in the atmospheres and interiors of these objects. Brown dwarfs rotate rapidly, and for plausible wind speeds, the flow at large scales will be rotationally dominated. We present 3D, global, numerical simulations of convection in the interior, which demonstrate that, at large scales, the convection aligns in the direction parallel to the rotation axis. Convection occurs more efficiently at high latitudes than low latitudes, leading to systematic equator-to-pole temperature differences that may reach ~1 K near the top of the convection zone. The interaction of convection with the overlying, stably stratified atmosphere will generate a wealth of atmospheric waves, and we argue that, as in the stratospheres of planets in the solar system, the interaction of these waves with the mean flow will cause a significant atmospheric circulation at regional to global scales. At large scales, this should consist of stratified turbulence (possibly organizing into coherent structures such as vortices and jets) and an accompanying overturning circulation. We present an approximate analytic theory of this circulation, which predicts characteristic horizontal temperature variations of several to ~50 K, horizontal wind speeds of ~10-300 m/sec, and vertical velocities that advect air over a scale height in ~10^5-10^6 sec. This vertical mixing may help to explain the chemical disequilibrium observed on some brown dwarfs. Moreover, the implied large-scale organization of temperature perturbations and vertical velocities suggests that, near the L/T transition, patchy clouds can form near the photosphere, helping to explain recent observations of brown-dwarf variability in the near-IR.
description: 21 pages, 9 figures, revised version, in press at ApJ
Graeme Barker und John Lloyd (Hrsg.), Roman Landscapes. Archaeological Survey in the Mediterranean Region
Creators: name: Pekáry, Thomas
Publisher: name: Bonner Jahrbücher
Year: 2019

description: Rezension zu: Graeme Barker und John Lloyd (Hrsg.), Roman Landscapes. Archaeological Survey in the Mediterranean Region. Archaeological Monographs of the British School at Rome, Band 2. British School at Rome, London 1991. XVI, 240 Seiten mit zahlreichen Abbildungen.
description: Bonner Jahrbücher, Bd. 193.1993(1994): Bonner Jahrbücher
Nonlinear Supersymmetric Quantum Mechanics: concepts and realizations
Creators: name: Andrianov, A. A.
name: Ioffe, M. V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Nonlinear SUSY approach to preparation of quantum systems with pre-planned spectral properties is reviewed. Possible multidimensional extensions of Nonlinear SUSY are described. The full classification of ladder-reducible and irreducible chains of SUSY algebras in one-dimensional QM is given. Emergence of hidden symmetries and spectrum generating algebras is elucidated in the context of Nonlinear SUSY in one- and two-dimensional QM.
description: 75 pages, Minor corrections, Version published in Journal of Physics A
Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes.
Creators: name: Furse, Samuel
name: Fernandez-Twinn, Denise S
name: Chiarugi, Davide
name: Koulman, Albert
name: Ozanne, Susan E
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: lipid metabolism
Hyperglycaemia
Gestational Diabetes
Mouse Model
Lipidomics
Lipid Traffic Analysis
Animals
Mice
Diabetes, Gestational
Obesity
Blood Glucose
Lipids
Glucose Tolerance Test
Pregnancy
Female
Lipid Metabolism

description: The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. Our results suggest that the start of pregnancy is associated with several changes in lipid metabolism, including fewer variables associated with de novo lipogenesis and fewer PUFA-containing lipids in the circulation. Several of the changes in lipid metabolism in healthy pregnancies were less apparent or occurred later in dams who developed GDM. Some changes in maternal lipid metabolism in the obese-GDM group were so late as to only occur as the control dams' systems began to switch back towards the non-pregnant state. These results demonstrate that lipid metabolism is modulated in healthy pregnancy and the timing of these changes is altered in GDM pregnancies. These findings raise important questions about how lipid metabolism contributes to changes in metabolism during healthy pregnancies. Furthermore, as alterations in the lipidome are present before the loss of glucose tolerance, they could contribute to the development of GDM mechanistically.
Record Performance of Electrical Injection Sub-wavelength Metallic-Cavity Semiconductor Lasers at Room Temperature
Creators: name: Ding, K.
name: Hill, M. T.
name: Liu, Z. C.
name: Yin, L. J.
name: van Veldhoven, P. J.
name: Ning, C. Z.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Metallic-Cavity lasers or plasmonic nanolasers of sub-wavelength sizes have attracted great attentions in recent years, with the ultimate goal of achieving continuous wave (CW), room temperature (RT) operation under electrical injection. Despite great efforts, a conclusive and convincing demonstration of this goal has proven challenging. By overcoming several fabrication challenges imposed by the stringent requirement of such small scale devices, we were finally able to achieve this ultimate goal. Our metallic nanolaser with a cavity volume of 0.67λ3 (λ=1591 nm) shows a linewidth of 0.5 nm at RT, which corresponds to a Q-value of 3182 compared to 235 of the cavity Q, the highest Q under lasing condition for RT CW operation of any sub-wavelength laser. Such record performance provides convincing evidences of the feasibility of RT CW metallic nanolasers, thus opening a wide range of practical possibilities of novel nanophotonic devices based on metal-semiconductor structures.
description: This paper has been withdrawn by the author after the final publication in Optics Express, 21, 4728(2013)
The discovery of an in situ Neanderthal remain in the Bawa Yawan Rockshelter, West-Central Zagros Mountains, Kermanshah
Creators: name: Heydari-Guran, Saman
name: Benazzi, Stefano
name: Talamo, Sahra
name: Ghasidian, Elham
name: Hariri, Nemat
name: Oxilia, Gregorio
name: Asiabani, Samran
name: Azizi, Faramarz
name: Naderi, Rahmat
name: Safaierad, Reza
name: Hublin, Jean-Jacques
name: Foley, Robert A.
name: Lahr, Marta M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: subject: Research Article
subject: Biology and life sciences
subject: Earth sciences
subject: Social sciences
subject: FOS: Social sciences
subject: Research and analysis methods
subject: Medicine and health sciences

description: Neanderthal extinction has been a matter of debate for many years. New discoveries, better chronologies and genomic evidence have done much to clarify some of the issues. This evidence suggests that Neanderthals became extinct around 40,000–37,000 years before present (BP), after a period of coexistence with Homo sapiens of several millennia, involving biological and cultural interactions between the two groups. However, the bulk of this evidence relates to Western Eurasia, and recent work in Central Asia and Siberia has shown that there is considerable local variation. Southwestern Asia, despite having a number of significant Neanderthal remains, has not played a major part in the debate over extinction. Here we report a Neanderthal deciduous canine from the site of Bawa Yawan in the West-Central Zagros Mountains of Iran. The tooth is associated with Zagros Mousterian lithics, and its context is preliminary dated to between ~43,600 and ~41,500 years ago.
Scattering by linear defects in graphene: a tight-binding approach
Creators: name: Rodrigues, J. N. B.
name: Peres, N. M. R.
name: Santos, J. M. B. Lopes dos
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We develop an analytical scattering formalism for computing the transmittance through periodic defect lines within the tight-binding model of graphene. We first illustrate the method with a relatively simple case, the pentagon-only defect line. Afterwards, more complex defect lines are treated, namely the zz(558) and the zz(5757) ones. The formalism developed, only uses simple tight-binding concepts, reducing the problem to matrix manipulations which can be easily worked out by any computational algebraic calculator.
description: 36 pages, 15 figures
Antimicrobial stewardship, therapeutic drug monitoring and infection management in the ICU: results from the international A- TEAMICU survey
Creators: name: Lanckohr, Christian
name: Boeing, Christian
name: De Waele, Jan J.
name: De Lange, Dylan W.
name: Schouten, Jeroen
name: Prins, Menno
name: Nijsten, Maarten
name: Povoa, Pedro
name: Morris, Andrew Conway
name: Bracht, Hendrik
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research
Antimicrobial stewardship
Therapeutic drug monitoring
Critical care
Multiresistant bacteria
Antibiotic

description: Abstract: Background: Severe infections and multidrug-resistant pathogens are common in critically ill patients. Antimicrobial stewardship (AMS) and therapeutic drug monitoring (TDM) are contemporary tools to optimize the use of antimicrobials. The A-TEAMICU survey was initiated to gain contemporary insights into dissemination and structure of AMS programs and TDM practices in intensive care units. Methods: This study involved online survey of members of ESICM and six national professional intensive care societies. Results: Data of 812 respondents from mostly European high- and middle-income countries were available for analysis. 63% had AMS rounds available in their ICU, where 78% performed rounds weekly or more often. While 82% had local guidelines for treatment of infections, only 70% had cumulative antimicrobial susceptibility reports and 56% monitored the quantity of antimicrobials administered. A restriction of antimicrobials was reported by 62%. TDM of antimicrobial agents was used in 61% of ICUs, mostly glycopeptides (89%), aminoglycosides (77%), carbapenems (32%), penicillins (30%), azole antifungals (27%), cephalosporins (17%), and linezolid (16%). 76% of respondents used prolonged/continuous infusion of antimicrobials. The availability of an AMS had a significant association with the use of TDM. Conclusions: Many respondents of the survey have AMS in their ICUs. TDM of antimicrobials and optimized administration of antibiotics are broadly used among respondents. The availability of antimicrobial susceptibility reports and a surveillance of antimicrobial use should be actively sought by intensivists where unavailable. Results of this survey may inform further research and educational activities.
Andreas Hensen, Das römische Brand- und Körpergräberfeld von Heidelberg, Band I
Creators: name: Henrich, Peter
Publisher: name: Bonner Jahrbücher
Year: 2019

description: Rezension zu: Andreas Hensen, Das römische Brand- und Körpergräberfeld von Heidelberg, Band I. mit Beiträgen von Susanne Biegert, Elske Fischer, Markus Helfert, Constanze Höpken, Renate Ludwig, Sylvia Mitschke, Tanja Märkle, Elisabeth Nuber, Boaz Paz, Annette Paetz gen. Schieck, Gerwulf Schneider und Rainer Wiegels. Forschungen und Berichte zur Vor- und Frühgeschichte in Baden-Württemberg, Band 108. Verlag Konrad Theiss, Stuttgart 2009. Ein Textband von 684 Seiten mit 61 zum Teil farbigen Abbildungen sowie 8 Tabellen, ein Tafelband von 600 Seiten mit 551 schwarzweißen und 19 farbigen Tafeln sowie 14 Teilkarten und ferner 1 Gesamtplan als Faltbeilage.
description: Bonner Jahrbücher, Bd. 210/211.2010/2011(2012): Bonner Jahrbücher
Extended Lyman-alpha emission from interacting galaxies at high redshifts
Creators: name: Yajima, Hidenobu
name: Li, Yuexing
name: Zhu, Qirong
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recent observations have discovered a population of extended Lya sources, dubbed Lyman-alpha blobs (LABs), at high redshift z ~ 3 - 6.6. These LABs typically have a luminosity of L ~ 10^42-10^44 erg/s, and a size of tens of kiloparsecs, with some giant ones reaching up to D ~ 100 kpc. However, the origin of these LABs is not well understood. In this paper, we investigate a merger model for the formation of LABs by studying Lya emission from interacting galaxies at high redshifts by means of a combination of hydrodynamics simulations with three dimensional radiative transfer calculations. Our galaxy simulations focus on a set of binary major mergers of galaxies with a mass range of 3-7 *10^12 Msun in the redshift range of z ~ 3 -7, and we use the newly improved ART^2 code to perform the radiative transfer calculations which couple multi-wavelength continuum, ionization of hydrogen, and Lya line emission. We find that intense star formation and enhanced cooling induced by gravitational interaction produce strong Lya emission from these merging galaxies. The Lya emission appears to be extended due to the extended distribution of sources and gas. During the close encounter of galaxy progenitors when the star formation rate peaks at ~ 10^3 Msun/yr, our model produces Lya blobs with luminosity of L ~ 10^42-10^44 erg/s, and size of D ~ 10-20 kpc at z>6 and D ~ 20-50 kpc at z ~ 3, in broad agreement with observations in the same redshift range. Our results suggest that merging galaxies may produce some typical LABs as observed, but the giant ones may be produced by mergers more massive than those in our model, or a combination of mergers and cold accretion from filaments on a large scale.
description: 8 pages, 5 figures, accepted for publication in ApJ, updated references to match published version
Seasonal Arctic sea ice forecasting with probabilistic deep learning
Creators: name: Andersson, Tom R.
name: Hosking, J. Scott
name: Pérez-Ortiz, María
name: Paige, Brooks
name: Elliott, Andrew
name: Russell, Chris
name: Law, Stephen
name: Jones, Daniel C.
name: Wilkinson, Jeremy
name: Phillips, Tony
name: Byrne, James
name: Tietsche, Steffen
name: Sarojini, Beena Balan
name: Blanchard-Wrigglesworth, Eduardo
name: Aksenov, Yevgeny
name: Downie, Rod
name: Shuckburgh, Emily
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/704/106/125
/704/172/4081
/639/705/117
/639/705/531
/139
/141
/129
/119
article

description: Abstract: Anthropogenic warming has led to an unprecedented year-round reduction in Arctic sea ice extent. This has far-reaching consequences for indigenous and local communities, polar ecosystems, and global climate, motivating the need for accurate seasonal sea ice forecasts. While physics-based dynamical models can successfully forecast sea ice concentration several weeks ahead, they struggle to outperform simple statistical benchmarks at longer lead times. We present a probabilistic, deep learning sea ice forecasting system, IceNet. The system has been trained on climate simulations and observational data to forecast the next 6 months of monthly-averaged sea ice concentration maps. We show that IceNet advances the range of accurate sea ice forecasts, outperforming a state-of-the-art dynamical model in seasonal forecasts of summer sea ice, particularly for extreme sea ice events. This step-change in sea ice forecasting ability brings us closer to conservation tools that mitigate risks associated with rapid sea ice loss.
Multifractality of quantum wave packets
Creators: name: Garcia-Mata, I.
name: Martin, J.
name: Giraud, O.
name: Georgeot, B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study a version of the mathematical Ruijsenaars-Schneider model, and reinterpret it physically in order to describe the spreading with time of quantum wave packets in a system where multifractality can be tuned by varying a parameter. We compare different methods to measure the multifractality of wave packets, and identify the best one. We find the multifractality to decrease with time until it reaches an asymptotic limit, different from the mulifractality of eigenvectors, but related to it, as is the rate of the decrease. Our results could guide the study of experimental situations where multifractality is present in quantum systems.
description: 6 pages, 4 figures, final version including a new figure (figure 1)
Embedding defect sites into hexagonal nondiffracting wave fields
Creators: name: Kelberer, Andreas
name: Boguslawski, Martin
name: Rose, Patrick
name: Denz, Cornelia
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a highly purposive technique to optically induce periodic photonic lattices enriched with a negative defect site by using a properly designed nondiffracting beam. As the interference of two or more nondiffracting beams with adequate mutual spatial frequency relations in turn reproduces a nondiffracting beam, we adeptly superpose a hexagonal and a Bessel beam to create the nondiffracting defect beam of demand. The presented wavelength-independent technique is of utmost universality in terms of structural scalability and does not make any specific requirements to the photosensitive medium. In addition, the technique is easily transferable to all pattern-forming holographic methods in general and its application is highly appropriate e.g. in the fields of particle as well as atom trapping.
description: 4 pages, 2 figures
Transmission of ‘ Candidatus Anaplasma camelii’ to mice and rabbits by camel-specific keds, Hippobosca camelina
Creators: name: Bargul, Joel L.
name: Kidambasi, Kevin O.
name: Getahun, Merid N.
name: Villinger, Jandouwe
name: Copeland, Robert S.
name: Muema, Jackson M.
name: Carrington, Mark
name: Masiga, Daniel K.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
Biology and life sciences
Medicine and health sciences
Research and analysis methods
Earth sciences

description: Funder: uk’s foreign, commonwealth & development office
description: Funder: swedish international development cooperation agency
description: Funder: swiss agency for development and cooperation
description: Funder: federal democratic republic of ethiopia
description: Funder: government of the republic of kenya
description: Anaplasmosis, caused by infection with bacteria of the genus Anaplasma, is an important veterinary and zoonotic disease. Transmission by ticks has been characterized but little is known about non-tick vectors of livestock anaplasmosis. This study investigated the presence of Anaplasma spp. in camels in northern Kenya and whether the hematophagous camel ked, Hippobosca camelina, acts as a vector. Camels (n = 976) and > 10,000 keds were sampled over a three-year study period and the presence of Anaplasma species was determined by PCR-based assays targeting the Anaplasmataceae 16S rRNA gene. Camels were infected by a single species of Anaplasma, ‘Candidatus Anaplasma camelii’, with infection rates ranging from 63–78% during the dry (September 2017), wet (June-July 2018), and late wet seasons (July-August 2019). 10–29% of camel keds harbored ‘Ca. Anaplasma camelii’ acquired from infected camels during blood feeding. We determined that Anaplasma-positive camel keds could transmit ‘Ca. Anaplasma camelii’ to mice and rabbits via blood-feeding. We show competence in pathogen transmission and subsequent infection in mice and rabbits by microscopic observation in blood smears and by PCR. Transmission of ‘Ca. Anaplasma camelii’ to mice (8–47%) and rabbits (25%) occurred readily after ked bites. Hence, we demonstrate, for the first time, the potential of H. camelina as a vector of anaplasmosis. This key finding provides the rationale for establishing ked control programmes for improvement of livestock and human health.
Euler Products beyond the Boundary
Creators: name: Kimura, Taro
name: Koyama, Shin-ya
name: Kurokawa, Nobushige
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 11M06

description: We investigate the behavior of the Euler products of the Riemann zeta function and Dirichlet L-functions on the critical line. A refined version of the Riemann hypothesis, which is named "the Deep Riemann Hypothesis" (DRH), is examined. We also study various analogs for global function fields. We give an interpretation for the nontrivial zeros from the viewpoint of statistical mechanics.
description: 16 pages, 20 figures; discussion in Sec. 3 extended; references added; figures and discussion added; references added
Die Veränderung der Mitarbeitenden - Zufriedenheit durch die Implementierung einer Adaption des Buurtzorg-Modells in einem psychosozialen Pflegeunternehmen
Creators: name: Jung, Selina
Publisher: name: Hochschule für Angewandte Psychologie FHNW
Year: 2023
Subjects: subject: Arbeitszufriedenheit
subject: Organisationales Commitment
subject: KAFA
subject: OCQ-G
subject: agil
subject: Pflegemodell
subject: Buurtzog
subject: ambulante Pflege
subject: psychosoziale Pflege
subject: Organisationsentwicklung
subject: 150 - Psychologie

description: In einem kleinen privaten Unternehmen für ambulante psychosoziale Pflege wurde das Pflegemodell in einer Adaption des Buurtzorg – Modells (agiles Pflegemodell) adaptiert. Hierbei wurde die neue Rolle der Koordinationsperson geschaffen. Zu zwei Erhebungszeitpunkten wurde innerhalb dieses Unternehmens folgenden Fragestellungen nachgegangen: Wie hat sich die Mitarbeitenden – Zufriedenheit durch die Implementierung der Koordinationsperson verändert? & Wie hat sich die Identifikation der Mitarbeitenden mit dem Unternehmen durch die Implementierung der Rolle der Koordinationsperson verändert? Mittels kombiniertem Fragebogen bestehend aus dem Kurzfragebogen für allgemeine und facettenspezifische Arbeitszufriedenheit (KAFA) und der deutschen Fassung des Organizational Commitment Questionnaire (OCQ- G) wurden zu beiden Erhebungszeitpunkten N 10 und N 8 Mitarbeitende online befragt. Der Wilcoxon – Test ergab keine signifikanten Veränderungen der Mitarbeitenden – Zufriedenheit und der Identifikation mit dem Unternehmen. Die Hypothese, dass die Arbeit im Buurtzorg – Modell die Arbeitszufriedenheit erhöht, musste verworfen werden. Dennoch konnten durch Mittelwerts - Vergleiche Unterschiede in den Facetten der Arbeitszufriedenheit festgestellt werden, welche Hinweise zu möglichen Gestaltungsmassnahmen offenlegten.
Room-temperature multiferroic hexagonal LuFeO$_3$ films
Creators: name: Wang, Wenbin
name: Zhao, Jun
name: Wang, Wenbo
name: Gai, Zheng
name: Balke, Nina
name: Chi, Miaofang
name: Lee, Ho Nyung
name: Tian, Wei
name: Zhu, Leyi
name: Cheng, Xuemei
name: Keavney, David J.
name: Yi, Jieyu
name: Ward, Thomas Z.
name: Snijders, Paul C.
name: Christen, Hans M.
name: Wu, Weida
name: Shen, Jian
name: Xu, Xiaoshan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The crystal and magnetic structures of single-crystalline hexagonal LuFeO$_3$ films have been studied using x-ray, electron and neutron diffraction methods. The polar structure of these films are found to persist up to 1050 K; and the switchability of the polar behavior is observed at room temperature, indicating ferroelectricity. An antiferromagnetic order was shown to occur below 440 K, followed by a spin reorientation resulting in a weak ferromagnetic order below 130 K. This observation of coexisting multiple ferroic orders demonstrates that hexagonal LuFeO$_3$ films are room-temperature multiferroics.
Future leader(ship) development – Analyse der Führungsaus- und Weiterbildung der Stadt Bern und Ableiten von Handlungsempfehlungen
Creators: name: Kauer, Melanie
Publisher: name: Hochschule für Angewandte Psychologie FHNW
Year: 2023
Subjects: subject: Führungskräfteentwicklung
subject: Führung
subject: Weiterbildung
subject: Führungskompetenzen
subject: Talentmanagement
subject: strategische Personalentwicklung
subject: 330 - Wirtschaft

description: Die vorliegende Bachelorthesis beschäftigt sich mit dem Thema Führungskräfteentwicklung bei der Stadt Bern. Massgebend war, dass die Teilnehmendenzahl bei den durch die Ausbildung und Organisationsberatung der Stadt Bern (AOB) angebotenen Vertiefungsmodulen stagnierend ist. Infolgedessen wurde anhand von acht leitfadengestützten Interviews mit Führungskräften und kursleitenden Personen sowie einer quantitativen Onlinebefragung erfasst, welches Unterstützungsangebot Führungskräfte der Stadt Bern brauchen, um ihre Führungstätigkeit heutzutage erfolgreich ausführen zu können und wie daraus aufseiten der AOB ein Angebot aussehen könnte, um dem zukünftigen Lernen der Führungskräfte zu entsprechen. Dabei hat sich gezeigt, dass vor allem finanzielle und zeitliche Ressourcen gewünscht werden. Mehr Unterstützungsmöglichkeiten im Rahmen eines Kurses werden bei der digitalisierten Zusammenarbeit und Kommunikation und Koordination im Team gewünscht. Ausserdem bevorzugen die Führungskräfte mehr Inputs zu den Themen agile Organisationsentwicklung, Change-Management, Kulturentwicklung, neue Arbeits- und Organisationsformen sowie Management und Strategie. Hinsichtlich der Entwicklung von Lernformaten sind ein- bis zweitägige gruppen- oder expertenorientierte Präsenzkurse aktuell und auch zukünftig gewünscht, jedoch wird das Blended-Learning-Format nach Ansicht der Führungskräfte zukünftig an Bedeutung gewinnen. Abschliessend wurden Möglichkeiten aufgezeigt, wie man die Kursqualität erhöhen könnte.
Optimising hadron collider simulations using amplitude neural networks
Creators: name: Moodie, Ryan
Publisher: name: Zenodo
Year: 2022

description: Phenomenological studies of high-multiplicity scattering processes at collider experiments present a substantial theoretical challenge and are increasingly important ingredients in experimental measurements. We investigate the use of neural networks to approximate matrix elements for these processes, studying the case of loop-induced diphoton production through gluon fusion. We train neural network models on one-loop amplitudes from the NJet library and interface them with the Sherpa Monte Carlo event generator to provide the matrix element within a realistic hadronic collider simulation. Computing some standard observables with the models and comparing to conventional techniques, we find excellent agreement in the distributions and a reduced simulation time by a factor of 30.
Fluctuations and differential contraction during regeneration of Hydra vulgaris tissue toroids
Creators: name: Krahe, Michael
name: Wenzel, Iris
name: Lin, Kao-Nung
name: Fischer, Julia
name: Goldmann, Joseph
name: Kästner, Markus
name: Fütterer, Claus
Publisher: name: arXiv
Year: 2012
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We studied regenerating bilayered tissue toroids dissected from Hydra vulgaris polyps and relate our macroscopic observations to the dynamics of force-generating mesoscopic cytoskeletal structures. Tissue fragments undergo a specific toroid-spheroid folding process leading to complete regeneration towards a new organism. The time scale of folding is too fast for biochemical signalling or morphogenetic gradients which forced us to assume purely mechanical self-organization. The initial pattern selection dynamics was studied by embedding toroids into hydro-gels allowing us to observe the deformation modes over longer periods of time. We found increasing mechanical fluctuations which break the toroidal symmetry and discuss the evolution of their power spectra for various gel stiffnesses. Our observations are related to single cell studies which explain the mechanical feasibility of the folding process. In addition, we observed switching of cells from a tissue bound to a migrating state after folding failure as well as in tissue injury. We found a supra-cellular actin ring assembled along the toroid's inner edge. Its contraction can lead to the observed folding dynamics as we could confirm by finite element simulations. This actin ring in the inner cell layer is assembled by myosin- driven length fluctuations of supra-cellular α-actin structures (myonemes) in the outer cell-layer.
description: 19 pages and 8 figures, submitted to New Journal of Physics
pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread
Creators: name: Benedyk, Tomasz H.
name: Muenzner, Julia
name: Connor, Viv
name: Han, Yue
name: Brown, Katherine
name: Wijesinghe, Kaveesha J.
name: Zhuang, Yunhui
name: Colaco, Susanna
name: Stoll, Guido A.
name: Tutt, Owen S.
name: Svobodova, Stanislava
name: Svergun, Dmitri I.
name: Bryant, Neil A.
name: Deane, Janet E.
name: Firth, Andrew E.
name: Jeffries, Cy M.
name: Crump, Colin M.
name: Graham, Stephen C.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
Biology and life sciences
Medicine and health sciences
Research and analysis methods

description: The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication and dissemination. While pUL21 has been shown to promote multiple steps of virus assembly and spread, the molecular basis of its function remained unclear. Here we identify that pUL21 is a virus-encoded adaptor of protein phosphatase 1 (PP1). pUL21 directs the dephosphorylation of cellular and virus proteins, including components of the viral nuclear egress complex, and we define a conserved non-canonical linear motif in pUL21 that is essential for PP1 recruitment. In vitro evolution experiments reveal that pUL21 antagonises the activity of the virus-encoded kinase pUS3, with growth and spread of pUL21 PP1-binding mutant viruses being restored in adapted strains where pUS3 activity is disrupted. This study shows that virus-directed phosphatase activity is essential for efficient herpesvirus assembly and spread, highlighting the fine balance between kinase and phosphatase activity required for optimal virus replication.
The axisymmetric antidynamo theorem revisited
Creators: name: Kaiser, Ralf
name: Tilgner, Andreas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The axisymmetric kinematic dynamo problem is reconsidered and a number of open questions are answered. Apart from axisymmetry and smoothness of data and solution we deal with this problem under quite general conditions, i.e. we assume a compressible fluid of variable (in space and time) conductivity moving in an arbitrary (axisymmetric) domain. We prove unconditional, pointwise and exponential decay of magnetic field and electric current to zero. The decay rate of the external (meridional) magnetic field can become very small (compared to free decay) for special flow fields and large magnetic Reynolds numbers. We give an example of that. On the other hand, we show for fluids with weak variation of mass density and conductivity that the meridional and azimuthal decay rates do not drop significantly below those of free decay.
description: Revised version, 28 pages, 1 figure
Access to Farmland by Beginning and Socially Disadvantaged Farmers: Issues and Opportunities
Creators: name: Callahan, Scott
name: Hellerstein, Daniel
name: Callahan, Scott
name: Hellerstein, Daniel
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: Agricultural Finance
subject: Community/Rural/Urban Development
subject: Financial Economics
subject: Industrial Organization
subject: Land Economics/Use
subject: Political Economy
subject: Production Economics
subject: land access
subject: land tenure
subject: landlords
subject: socially disadvantaged (SDA) farmers
subject: beginning farmers
subject: TOTAL survey

description: The 2017 Census of Agriculture reported that more than one-third of producers are over 65 years of age, and the distribution of agricultural land has shifted to fewer, larger landholders. Socially disadvantaged (SDA) producers (classified by race, ethnicity, and/or gender) may have fewer financial resources and face additional constraints when buying or raising capital for expanding farm operations. This report used USDA survey, census, and administrative data to examine measures of land access and other factors associated with the share of SDA and beginning farmers and ranchers in a county in 25 States. Several measures of land tenure, federal program participation, agricultural sales, and demographic information were used to estimate how land access and federal programs correlate with the percentage of SDA and beginning farming operations at the county level. The percentage of beginning farmers and ranchers in a county is positively correlated with the percent of rented farmland acres and negatively correlated with crop insurance premiums (measured in dollars per acre) and average farmer age. The study also found the percentage of SDA operations in a county is negatively correlated with the percentage of sales in field crops and positively correlated with the percentage of USDA’s Farm Service Agency (FSA) loan applications granted, and percentage of direct-to-consumer sales. Results indicated the average lease size, the percentage of livestock sales, and decreasing urbanization are negatively correlated with the percentage of SDA and beginning operations. In contrast, the percentage of rented farmland and the percentage of SDA populations are positively correlated with the percentage of SDA operators in a county.
Velocity distribution function and effective constant restitution coefficient for granular gas of viscoelastic particles
Creators: name: Dubey, Awadhesh Kumar
name: Bodrova, Anna
name: Puri, Sanjay
name: Brilliantov, Nikolai
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We perform large-scale event-driven Molecular dynamics (MD) simulations for granular gases of particles interacting with the impact-velocity dependent restitution coefficient. We use the simplest first-principle collision model of viscoelastic spheres. Both cases of force-free and uniformly heated gases are studied. We formulate a simplified model of an effective constant restitution coefficient, which depends on a current granular temperature and compute the effective constant restitution coefficient, using the kinetic theory. We develop a theory of the velocity distribution function for driven gases of viscoelastic particles and analyze evolution of granular temperature and of the Sonine coefficients, which characterize the form of the velocity distribution function. We observe that for not large dissipation the simulation results are in an excellent agreement with the theory for both, homogeneous cooling state and uniformly heated gases. At the same time a noticeable discrepancy between the theory and MD results for the Sonine coefficients is detected for large dissipation. We analyze the accuracy of the simplified model, based on the effective restitution coefficient and conclude that this model can accurately describe granular temperature. It provides also an acceptable accuracy for the velocity distribution function for small dissipation, but fails when dissipation is large.