cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Trypanocide usage within livestock breeds of Uganda
Creators: name: Kasozi, Keneth Iceland
name: MacLeod, Ewan Thomas
name: Welburn, Susan Christina
Publisher: name: University of Edinburgh. Edinburgh Medical School. Infection Medicine Division
Year: 2026
Subjects: subject: Neglected Tropical Diseases
subject: Stamp out sleeping sickness
subject: Trypanocide resistance in Uganda
subject: Value for money and trypanocide misuse in Uganda
subject: Medicine and Dentistry

description: The script supports Chapter 4 Subsection 3 titled: “Trypanocide overdosing in livestock breeds” from my PhD thesis titled: Exploring trypanocide resistance: Lessons from Uganda (2024). This describes data (referenced as “Econ”) where the value for money is assessed in the community is presented. Responses are from 557 farmers who have been associated with heavy trypanocide consumption in southwestern Uganda. The loss expenditure frontier curve (LEF) models livestock losses and income per head among cattle and small ruminants in the study area. Weight estimates are applied on all livestock to quantify the effective dose (i.e., the amount of drug administered per animal) based on the number of sachets consumed per farmer. The net income adjusted herd size ratio (NIAHSR) measured money gained while the expenditure income adjusted herd size ratio (EIRAHS) was the proportion of money earned, that is spent on each livestock as a measure of money lost per animal.
description: The script supports Chapter 4 Subsection 3 titled: “Trypanocide overdosing in livestock breeds” from my PhD thesis titled: Exploring trypanocide resistance: Lessons from Uganda (2024). This describes data (referenced as “Econ”) where the value for money is assessed in the community is presented. Responses are from 557 farmers who have been associated with heavy trypanocide consumption in southwestern Uganda. The loss expenditure frontier curve (LEF) models livestock losses and income per head among cattle and small ruminants in the study area. Weight estimates are applied on all livestock to quantify the effective dose (i.e., the amount of drug administered per animal) based on the number of sachets consumed per farmer. The net income adjusted herd size ratio (NIAHSR) measured money gained while the expenditure income adjusted herd size ratio (EIRAHS) was the proportion of money earned, that is spent on each livestock as a measure of money lost per animal.
title: Quality of trypanocides from Uganda
title: hplc of trypanocides
titleType: AlternativeTitle
title: drug quality
titleType: AlternativeTitle
title: counterfeits
titleType: AlternativeTitle
title: R script
titleType: AlternativeTitle
Creators: name: Kasozi, Keneth Iceland
name: MacLeod, Ewan Thomas
name: Welburn, Susan Christina
Publisher: name: University of Edinburgh. Edinburgh Medical School. Infection Medicine Division
Year: 2026
Subjects: subject: Neglected Tropical Diseases
subject: Trypanocide resistance
subject: Stamp out sleepign sickness
subject: Medicine and Dentistry

description: We explored the quality of trypanocides sold on the Ugandan market by conducting a high performance liquid chromatography on all the samples from 45 drugshops. This was to investigate their quality against internationally established standards. The R script summaries the statistical approach used to explore this research question.
A study of some molecular addition compounds of zirconium and hafnium tetrahalides.
Creators: name: Chung, F. M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1967
Subjects: subject: Chemistry, Inorganic.

description: addition complexes MX4-2L, where M is Zr or Hf, x is C1 or Br, and L is tetrahydrofuran or tetrahydrothiophene have been prepared. Thermochemical data have been obtained and the results are interpreted. The enthalpies of reaction of MX(c) - 2L-MX4-2L(c) was measured calorimetrically and the values converted to gas phase and correlated in terms of polarizability and steric effects. The compounds MX4 appear to be on the borderline between class a and class b behavior with hafnium showing a very slightly greater tendency toward class b behaviour. The nuclear magnetic resonance spectra have been obtained for these complexes and the internal chemical shifts determined. The order of the increasing internal shift correlates satisfactorily with the order of internal stability of the complexes. Triphenyl phosphine oxide and triphenyl arsine oxide complexes of zirconium tetrachloride and hafnium tetrachloride have been prepared, they are 1:2 addition complexes except ZrCl4-3Ph3AsO which is a 1:3 addition complex. They are insoluble in common solvents tested, hence neither the thermal measurements nor the n. m. r. spectrometry was carried out. Instead, their infrared spectra were studied with those of corresponding niobium complexes which have also been prepared as 1:2 addition compounds. The analyses of the shifts of the P-O and As-O stretching frequencies confirm the relative hardness of zirconium(IV) chloride and hafnium(IV) chloride as Lewis acids, hence the relative tendency toward class b behaviour thermochemically observed for zirconium and hafnium.
3722977.pdf
Creators: name: Paniagua-Diaz, Alba
name: Starshynov, Illia
name: Fayard, Nikos
name: Goetschy, Arthur
name: Pierrat, Romain
name: Carminati, Remi
name: Bertolotti, Jacopo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental theory and experimental methods
The Jewish ossuary phenomenon: Cultural receptivity in Roman Palestine
Creators: name: Teitelbaum, Dina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Religion, History of.
subject: Anthropology, Archaeology.
subject: History, Middle Eastern.

description: The discovery of Jewish ossuaries in the nineteenth century raised a host of questions, paramount among them the questions of the origin and purpose of the ossuaries. It was also realized that ossuaries were a short lived phenomenon, appearing and disappearing relatively suddenly. A number of theories were proposed: The ossuaries were thought to have to do either with transport or space-saving, protection, martyrdom, resurrection, atonement, individuation, or Roman convention. All of these theories focused on Judea as the origin of the phenomenon. However, no one theory was satisfactory in itself. The dissertation presents a fresh examination of all available evidence in the light of ancient Jewish burial customs from the First Temple period to the Hellenistic and Roman times, using the approaches of archaeology, anthropology, and socio-rhetorical analysis. It concludes that foreign influence triggered the adoption of the ossuary in Judea during the Herodian period and that Judeans adopted the Greco-Roman ash chest as a model, modifying an aniconic version for use with bones alone. A comparison of the Jewish ossuary with the Greco-Roman ash urn reveals parallels and striking similarities in terms of ritual, material culture, terminology, manufacture and time lines. In particular, the temporal distribution of ossuaries and ash chests points to a general diffusion of the concept throughout the Empire over a long period of time, with ossuaries appearing relatively late in Judea. Using the innovation-diffusion theory of Roberts, the dissertation argues that, once implanted, the idea of ossuaries, in conjunction with ossilegium, spread rapidly throughout Judea, each special interest group or individual adopting it for their own unique reasons. Ultimately it became a fashionable secondary burial instrument. The disappearance of the Judean ossuary can be explained in terms of the adoption of the subsequent fashion in the Roman Empire to bury the dead in coffins or sarcophagi. In conclusion, it has been shown in the dissertation that Jews of the Second Temple Period were attracted to, adopted, re-invented and reconfigured a foreign convention in such a way that it became consistent with their Torah laws and their beliefs.
Conserving biodiversity in agriculture-dominated landscapes: Loss of natural habitat drives lepidopteran declines at multiple spatial scales
Creators: name: Feswick, April Amanda Melissa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Ecology.

description: The expansion of agriculture throughout the world has precipitated serious biodiversity losses. Countries with relatively extensive natural habitats, such as Canada, continue to intensify agricultural land uses, threatening to expand the scope of the present mass extinction. This thesis tests likely mechanisms of butterfly species decline in agricultural landscapes of varying intensities in the most biologically diverse region of Canada. I measured site variables such as the richness of plants suitable for larval development, patch area and shape index, and landscape variables such as heterogeneity and land-cover within buffers that varied in size from 100m to 1000m. Several rare species were not present in the agricultural sites, whereas a few species typically associated with disturbed habitat were present and abundant among most study sites. I found that agricultural intensification acts across landscapes to reduce butterfly species richness by reducing the proportion of natural habitat available. This effect was especially pronounced at 100m to 200m distances, suggesting a threshold effect beyond which the proportion of natural land is less critical to butterfly biodiversity. Within-site factors, such as plant species richness and habitat area were not affected by agricultural intensity, nor did they affect butterfly species richness and abundance. These results suggest that the mechanism linking butterfly species decline to agriculture, at least for butterflies in this region, is the loss of small habitat remnants.
Design of a model mount for near-surface submarine experiments
Creators: name: Tandon, Varun
Publisher: name: University of Iowa
Year: 2022
Subjects: Submarine model experiments
public abstract
Hydrodynamics

description: Current captive submarine models have a limited range of capabilities for experimentsinvolving surfaced or near-surface operations. The presence of interference caused by required mounting structures distorts fluid flows and model reactions thereby preventing the capture of accurate force and moment data. Development of computational fluid dynamics (CFD) has helped to augment physical experiments with CFD simulation data. However, these data, specifically for surface/near-surface experiments, are difficult to verify and validate due to the complexities of physically modeling a free-surface environment with a captive model.
description: A wire suspension mount will greatly minimize mount interference and allow enough flexibility for a model to react appropriately without distortion of the reaction forces. This paper explores the initial steps to design this mount by developing a mathematical model to validate wire suspension as a viable mounting method for water environments.
title: Context matters
title: regulation and function of CD4 T cells responding to infection
titleType: Subtitle
Creators: name: Johnson, Jordan T.
Publisher: name: University of Iowa
Year: 2025

description: Malaria is a systemic disease caused by the Protozoan Plasmodium parasite with an estimated 249 million clinical cases and 608,000 deaths reported annually. Current therapeutic strategies fail to elicit sterilizing humoral immunity. Development of Plasmodium-specific humoral immunity is critically dependent on CD4 helper T cell responses and germinal center (GC) reactions during blood-stage Plasmodium infection. Thus, it remains important to refine our understanding of how the function of CD4 T cells distinctly regulates the development of Plasmodium-specific protective immunity. My thesis work focused on how CD4 T cell-derived cytokines regulate immune responses to murine Plasmodium infection. Using mouse models of blood-stage Plasmodium infection, I investigated whether sustained CD4 T cell-derived IL-21 in established germinal centers (GCs) is required for GC maintenance and output. Utilizing a novel inducible knockout mouse model that enabled timed deletion of Il21 in peripheral CD4 T cells, I found that memory B cells generated in the absence of IL-21 exhibited reduced recall function upon challenge. These data highlight that sustained IL-21 prevents premature cellular dissolution within the GC and promotes stringency of selective pressures during B cell fate determination required to produce high-quality Plasmodium-specific MBCs. These data additionally reveal that IL-21 regulates and supports selection of MBCs independent of type I and type II interferon signaling. These data are additionally consistent with a temporal requirement for IL-21 in fine-tuning humoral immune memory responses during experimental malaria. Together, my thesis work provides evidence that CD4 T cell functions program long-term protective immunity in a context dependent manner.
Alterity and division in Marcel Gauchet.
Creators: name: Noel De Tilly, Manon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Political Science, General.

description: This research project will put forth an examination of the works of Marcel Gauchet on the subject of alterity and division and his questioning of their role in defining political and social organization. The recent presence of division and alterity, (or otherness) will be retraced through the transformation from earlier to modern societies, pausing to understand the phenomenon of the appearance of the State in human history. It will focus particular attention on the continuing role of alterity in modern and democratic society.
Calculating the diffusion coefficient of a random walker among immobile obstacles: New numerically exact theory and applications.
Creators: name: Mercier, Jean-François.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Mathematics.

description: Many biological, chemical and physical problems can be reduced to that of the diffusion of a particle in a quenched system of obstacles. For example, the diffusion of proteins in the plane of a biomembrane, the migration of analytes in low field gel electrophoresis and the diffusion of particles in porous media can all be reduced to such systems. The standard method to study such problems is to use Monte Carlo simulations on finite-size lattices with periodic boundary conditions. This approach is very simple and one can obtain diffusion coefficients with error bars as small as 0.1%. We developed a new algebraic method to calculate the exact diffusion coefficients for those systems. This method can treat systems similar (in size and complexity) to the ones currently studied with Monte Carlo simulations, but gives exact results and usually requires less CPU time. Furthermore, this new approach can easily be adapted to any type of lattice in any dimensionality greater than one. After explaining the new method and its numerical implementation, some examples will be given to demonstrate both its viability and its power. Finally, a standard mean-field theory of gel electrophoresis, which predicts that the mobility of charged particles is directly related to the fractional gel volume available to it, will be tested for three-dimensional gels.
3726203.pdf
Creators: name: zhang, Shuangyou
name: Silver, Jonathan
name: Del Bino, Leonardo
name: Copie, Francois
name: Woodley, Michael
name: Ghalanos, George
name: Svela, Andreas
name: Moroney, Niall
name: Del'Haye, Pascal
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Material
Net shoulder joint moment and muscular activity during light weight handling at different heights and frequencies.
Creators: name: Giroux, Benoit.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Animal Physiology.

description: Ten (10) normal adult male subjects were asked to move a known weight, representing 15% of the maximal lifted weight, in both horizontal and vertical conditions at frequencies of 40 cycles/min and 60 cycles/min. Raw EMG signals from six (6) shoulder muscles were recorded and synchronized with the cinematographic data during three (3) trials of six (6) seconds each. The raw EMG signals of each muscle were full wave rectified and filtered at three (3) Hz. The LE EMG signals were normalized by time (% cycle) and by amplitude (% MVC), and for the analysis of variance, the normalized LE EMG signals were integrated (IN LE EMG). The average shoulder angular velocities, joint moments and moment powers were computed from cinematographical data. No significant difference were observed between both tasks for the supraspinatus, infraspinatus, and pectoralis major IN LE EMG data as well as for integrated normalized shoulder joint moment for the whole cycle of movement. IN LE EMG data from middle deltoid, anterior deltoid, and trapezius muscles were significantly higher (p 0.05) when performing the vertical displacement task for the whole cycle of movement. (Abstract shortened by UMI.)
A smart solar energy collecting device
Creators: name: Westgate, Timothy M.
name: Boivin, Adrian
name: Holzman, Jonathan
name: Veerman, Blake W. D.
name: Bergen, Mark
name: Jin, Xian
name: Born, Brandon
name: Bernier, Mike
Publisher: name: SPIE
Year: 2021

description: Flat silicon solar cells are the standard for solar technology implementations, due to the simplicity of its form and the low cost of its material. However, the bare material of such a technology is known to suffer from high reflectivity and low solar conversion efficiency. Engineered surfaces (e.g., textured) and bulk structures (e.g., quantum dots) are often used to diminish the reflection and enhance the efficiency, but such processes come at the expense of complexity and cost. The proposed work responds to these challenges by introducing a new architecture for traditional silicon solar technology. The architecture takes the form of a Smart Solar Sensing (S-Cubed) Array. It consists of a macroscopic close-packed array of corner-cube- (CC-) shaped solar cells. Each CC-cell has three silicon solar cells lining its interior corners. The three silicon solar cells establish multiple internal reflections for enhanced overall absorption. At the same time, the impedances of the three silicon solar cells in each CC-cell of the S-Cubed Array can be sensed and independently matched to a common load. This allows for maximized electric power transfer to the load over a broad range of illumination conditions. It is shown in this work that the collected energy density of the CC-cell array, over the course of a day, can be increased by 33.02% when compared to an array of conventional (flat) silicon solar cells. Such findings can lay the groundwork for future implementations of high-efficiency solar technology
Untersuchung von Instrumenten und Maßnahmen zur Erschließung des aus Klimaschutzsicht zusätzlich erforderlichen Erneuerbaren-Energien-Ausbaus
Creators: name: Bauknecht, Dierk
name: Ritter, David
name: Palacios, Sebastian
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Photovoltaik
subject: Windenergie
subject: Klimaschutz
subject: Rahmenbedingungen
subject: Hemmnisse
subject: Klima | Energie

description: Dem aus Klimaschutzsicht zusätzlich erforderlichen Erneuerbare-Energien-Ausbau steht eine Reihe von Hemmnissen entgegen. Das Vorhaben untersucht, wie Rahmenbedingungen angepasst werden müssen, um diese Hemmnisse zu reduzieren. Zuerst werden unterschiedliche Klimaschutzszenarien ausgewertet, um den Ausbau erneuerbarer Energien zu ermitteln, der zur Erreichung der Klimaschutzziele notwendig ist. Eine Reihe von Gutachten im Rahmen des Projektes entwickelte konkrete Abhilfemaßnahmen gegen Hemmnisse beim Ausbau erneuerbarer Energien. Die Themen umfassen unter anderem die Flächenbereitstellung für die Windenergie an Land, eine Photovoltaik-Pflicht mit Verpachtungskataster und deren Potenzialanalyse, sowie Ansätze zur Nutzung von PV-Dachpotenzialen jenseits von Eigenversorgungskonzepten. Quelle: Forschungsbericht
description: Several obstacles stand in the way of the additional expansion of renewable energies that is required from a climate protection perspective. The project examines how framework conditions must be adjusted in order to reduce these obstacles. First, different climate protection scenarios are evaluated in order to determine the expansion level of renewable energies that is necessary to achieve climate protection goals. A number of reports developed specific remedial measures against barriers to the expansion of renewable energies. The topics include, among others, the provision of land for onshore wind energy, a photovoltaic obligation with a leasing cadastre and an analysis of its potential, as well as approaches for the utilisation of PV roof space beyond self-consumption systems. Quelle: Forschungsbericht
description: Dem aus Klimaschutzsicht zusätzlich erforderlichen Ausbau erneuerbarer Energien steht eine Reihe von Hemmnissen entgegen. Das Vorhaben „klimagerechter EE-Ausbau“ untersuchte, wo zentraler Handlungsbedarf besteht und wie Rahmenbedingungen angepasst werden müssen, um Hemmnisse zu reduzieren. Dafür wurden unterschiedliche Klimaschutzszenarien ausgewertet, um den Ausbau erneuerbarer Energien zu ermitteln, der zur Erreichung der Klimaschutzziele notwendig ist. Anschließend wurden in einer Reihe von Kurzgutachten konkrete Abhilfemaßnahmen entwickelt. Die Themen umfassen unter anderem die Flächenbereitstellung für die Windenergie an Land, eine Photovoltaik-Pflicht mit Verpachtungskataster und deren Potenzialanalyse, sowie Ansätze zur Nutzung von Photovoltaik-Dachpotenzialen jenseits von Eigenversorgungskonzepten.
Design and implementation of a natural language based expert system for a multimedia database.
Creators: name: Shaw, Goutam Kumar.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Electronics and Electrical.

description: This thesis is concerned with the design and implementation of a Natural Language Based Expert System for a Multimedia Database for radiology applications. The design consists of three independent modules, namely the Natural Language Processor, the Expert System for query analyzing and result outputting, and the Database Management module (query execution module). These modules interact with each other through shared data and storage areas. The thesis emphasizes the integration of an expert system with a database management system to retrieve multimedia data stored in the database. At this stage of the development, all the three modules can interact with each other. The input to the system is a query in English for retrieving the data from the database. The system can check the syntax and semantics of the input queries, generate as well as execute equivalent database queries, and produce adequate results. The Natural Language Interface and the query and result analyzers are written in MPROLOG on a SUN workstation, whereas the database software module is written in C with embedded SQL commands for retrieving the data managed by ORACLE Relational DBMS. Examples of data modeling and the system organization are discussed and some sample runs are illustrated.
Local government in Nigeria: A study of resource allocation in Imo State.
Creators: name: Elliott, Bryan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Geography.

description: This study concentrates on primary education and community projects as analytical tools. It hypothesizes that there is an hierarchy of allocation that mirrors core-periphery relations of regions, and that there is a rural-urban dichotomy in the endowment of specific Local Government Areas (LGAs). The combined evidence of the distribution of teachers and of pupils by sex, and of budgeted amounts for community projects, suggests a three-level division of LGAs. There are low-endowment rural LGAs, having high male-to-female teacher ratios and, to some degree, more male than female pupils. There are high-endowment rural LGAs, with rough parity of teacher and pupil ratios, and varied--but high--levels of project budget. Finally, there are urban LGAs, with high female-to-male teacher ratios, a tendency for female pupils to outnumber male, and very low community project budgets. However, these divisions are based on crude statistics, rank-ordered, and take no account of effects of the larger region (i.e. Eastern Nigeria). The preliminary interpretation, which does support a rural-urban endowment dichotomy, is of limited value because statistics essential to a definitive conclusion are unavailable. (Abstract shortened by UMI.)
Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson's Disease Dementia
Creators: name: Kronimus, Yannick
name: Albus, Alexandra
name: Balzer-Geldsetzer, Monika
name: Straub, Sarah
name: Semler, Elisa
name: Otto, Markus
name: Klotsche, Jens
name: Dodel, Richard
name: Mengel, David
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background and Objective Altered levels of naturally occurring autoantibodies (nAbs) against disease-associated neuronal proteins have been reported for neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's disease (PD). Recent histopathologic studies suggest a contribution of both Lewy body- and AD-related pathology to Parkinson's disease dementia (PDD). Therefore, we explored nAbs against alpha-synuclein (αS), tau and β-amyloid (Aβ) in PDD compared to cognitively normal PD patients. Materials and Methods We established three different ELISAs to quantify the nAbs-tau, nAbs-αS, and nAbs-Aβ levels and avidity towards their specific antigen in serum samples of 18 non-demented (PDND) and 18 demented PD patients (PDD), which were taken from an ongoing multi-center cohort study (DEMPARK/LANDSCAPE). Results PDD patients had significantly decreased nAbs-tau serum levels compared to PDND patients (p = 0.007), whereas the serum titers of nAbs-αS and nAbs-Aβ were unchanged. For all three nAbs, no significant differences in avidity were found between PDD and PDND cohorts. However, within both patient groups, nAbs- tau showed lowest avidity to their antigen, followed by nAbs-αS, and nAbs-Aβ. Though, due to a high interassay coefficient of variability and the exclusion of many samples below the limit of detection, conclusions for nAbs-Aβ are only conditionally possible. Conclusion We detected a significantly decreased nAbs- tau serum level in PDD patients, indicating a potential linkage between nAbs- tau serum titer and cognitive deficits in PD. Thus, further investigation in larger samples is justified to confirm our findings.
An integrated flood impact assessment framework for mitigation and decision support systems
Creators: name: Alabbad, Yazeed
Publisher: name: University of Iowa
Year: 2023
Subjects: Accessibility analysis
Flood Exposure
Flood mitigation
Flood Vulnerability
Information system
Transportation damage
public abstract
Information Technology

description: Flooding is one of the most prevalent types of natural disasters affecting communities worldwide. It is expected to persist with increasing magnitude and frequency due to climate change, leading to direct and indirect negative consequences. The flood impact assessment is considered as a critical component of flood risk management strategies, such as benefit-cost analysis for mitigation planning. However, it is a complicated procedure and requires significant resources and skills, posing challenges for communities with limited resources. This dissertation investigates the socioeconomic impacts of flooding on diverse aspects (e.g., population, infrastructure) and geospatial scales in the State of Iowa. The study also conducts a thorough benefit-cost analysis of flood mitigation applications (e.g., elevation, wet floodproofing) and develops accessible web-based analytical systems to communicate flood-related adverse effects, promote mitigation practices, and assist with mitigation decisions. The findings reveal that Iowa's communities and counties are unequally impacted by flooding and identify economically feasible flood mitigation measures at the community-level.
description: Also, the web-based applications developed in this study facilitate the dissemination of flood-related information to various stakeholders, including the public, without requiring additional software installation on the user's local workstation. This research aimed to improve understanding of flood impacts, identify vulnerable areas, assess and prioritize mitigation initiatives, and involve various stakeholders in flood risk management. The approach can also be implemented in diverse geographic scales, leading to evidence-based decision-making in flood risk management.
3722977.pdf
Creators: name: Paniagua-Diaz, Alba
name: Starshynov, Illia
name: Fayard, Nikos
name: Goetschy, Arthur
name: Pierrat, Romain
name: Carminati, Remi
name: Bertolotti, Jacopo
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplemental theory and experimental methods
Enhancement of vesiculovirus oncolysis by expression of exotic envelope proteins
Creators: name: Brown, Christopher W
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Microbiology.
subject: Biology, Virology.
subject: Health Sciences, Oncology.

description: Viral treatment of cancer has been described since the beginning of the twentieth century. With the increasing need for effective targeted cancer therapies, the oncolytic virus platform has been revisited. Clinical trials have demonstrated that oncolytic viruses are well tolerated, but their ability to eliminate tumor burden or effectuate cures is poor. This thesis attempts to address enhancing the oncolytic virus efficacy. The strategy is to modulate characteristics of the rhabdovirus by adding or swapping envelope genes of interest in order to enhance oncolytic activity, specifically by addressing tumor spread, immune evasion and safety. The fusogenic protein from reovirus is used to generate a recombinant VSV to enhance viral spread within the tumor. Similarly, recombinant VSVs are generated with envelope proteins either from other vesiculovirus members or from a beta-retrovirus, and used to demonstrate tumor infectivity in the presence of neutralizing antibodies. The recombinant VSV expressing the beta-retrovirus envelope protein demonstrates altered viral tropism, and like the replication incompetent VSV/FAST recombinant is not neurotoxic in animal models.
Entwicklung einer neuen, harmonisierten Testprozedur im Rahmen der Fahrzyklusentwicklung (WLTP) für Pkw und leichte Nutzfahrzeuge in der UN/ECE
Creators: name: Schmidt, Helge
Publisher: name: My University
Year: 2019
Subjects: subject: Abgas
subject: Kohlendioxid
subject: Fahrzyklus
subject: Luftschadstoff
subject: Personenkraftwagen
subject: Kfz-Abgas
subject: WLTP
subject: CO2
subject: Luftschadstoff-Emissionen
subject: Luftschadstoffausstoß
subject: PKW
subject: Leichte Nutzfahrzeuge
subject: Autoabgas
subject: Verkehr

description: Die Wirtschaftskommission für Europa hat die neue weltweit harmonisierte Testprozedur für leichte Kraftfahrzeuge (Worldwide harmonised Light vehicle Test Procedure / WLTP) im Auftrag der EU-Kommission entwickelt. Ziel war es, die Abgasgesetzgebung für Pkw und leichte Nutzfahrzeuge zu verbessern und diese realistischer zu prüfen. Das Vorhaben hat in diesem Zusammenhang erfolgreich Fragestellungen beantwortet, die bei der Entwicklung von WLTP auftraten. Grundlage waren theoretische Studien und praktischen Messungen, deren Ergebnisse in den laufenden WLTP-Entwicklungsprozess einflossen. Im Bericht werden wichtige untersuchte Aspekte sowie generelle Änderungen durch den WLTP beschrieben.
A mechanistic understanding of surface chemistry at MXene Ti3C2, Ti2TaC2) interfaces
Creators: name: Rivera Bustillo, Victoria María
Publisher: name: University of Iowa
Year: 2024
Subjects: public abstract

description: Graphene-like transition metal carbides or MXenes (Mn+1Xn) are an emerging class of 2D nanomaterial first synthesized in 2011 with applications in fields such as environmental science and energy storage. They are synthesized from a MAX (Mn+1AXn) bulk phase where M is an early transition metal, A is an element such as Si or Al, and X is C or N. The A element is removed in an acid treatment such as aqueous HF/HCl and leaves behind the MXene Mn+1Xn layers. During this process, functional groups from solution such as -O, -F, and -OH attach to the outer transition metals and form surface terminations on the MXene. These surface terminations are critical to understanding the functionality of the material, and our work studies the favorability of different surface terminations at varying pH by use of a density functional theory (DFT) and thermodynamics approach. Using Ti3C2 as a case study, we have determined the energetics of the different functional groups (-O, -OH, -F) on the surface. In order to further investigate those trends, we also model the double transition metal (DTM) MXene Ti2TaC2, where the MXene’s inner metal layer is tantalum instead of titanium to give a slightly different electronic structure to the lattice. Our goal is to be able to predict MXene surfaces for a range of M compositions and environments to further understanding of MXene functionality and be able to design them for desired applications.
Impacts of biofilm on diffusion in fractured rock
Creators: name: Ghassemi, Hooman
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Environmental.

description: Fractured rock aquifers consist of complex flow systems that impose several constraints on cleanup efforts. Remedial techniques in such aquifers are influenced by diffusion of contaminants into the rock matrix and the subsequent back diffusion into the fracture. In particular, the back diffusion process can release a low concentration of contaminant into the groundwater for an extended period of time alter the main source of contamination is removed from the fracture network. Biofilms have been defined as cells immobilized on a solid surface and embedded in a gel matrix of extra-cellular polymeric substances (EPS) excreted by microorganisms. Biofilms can be stimulated on rock surfaces to act as a barrier in groundwater systems, which influences hydraulic properties of the fractured media as well as the rate of contaminant transport between the rock matrix and the fracture. The main objective of this study was to assess the potential of a biofilm to limit diffusion between the host rock and fracture. The impacts of different types of microorganisms on the diffusion rate were compared, and the performances of the tracers employed in diffusion experiments were evaluated. P. putida, E. coli and an indigenous groundwater population were used to grow biofilm on porous ceramic disks with nominal pore diameter of 6 mum. Disks were installed into stainless steel double-reservoir cells. The source reservoirs were spiked to obtain initial concentrations of 1500 ppm of bromide and 5000 ppb of Lissamine. In total, 17 experiments were conducted to assess the diffusion. Finally, a semi analytical model was used to interpret the geometric factors (tortuosity) of the porous media and the impacts of the biofilm on the effective diffusion coefficient. Results, estimated from bromide and Lissamine concentration profiles, did not suggest a significant impact of biofilm on the diffusion through the ceramic disks. This could be due to heterogeneity of biofilm structures, loose structures of developed biofilms, lack of biofilm penetration into the pores inside the disks as a result of nutrient overloading or biofilm decay/detachment during the test. In addition, Lissamine did not appear to perform as a conservative tracer in some cases where mass balance calculations indicated a loss of dye. It was recommended to characterize the biofilm structure as well as the biofilm impregnated zone, and to adjust the nutrient loading in order to obtain a more packed structure for the biofilm developed by small size bacteria. Recommendations also included a thorough evaluation of Lissamine behaviour as a conservative tracer.
Efficient data-driven inference and uncertainty quantification for surrogate modeling and inverse problems
Creators: name: Pensoneault, Andrew J.
Publisher: name: University of Iowa
Year: 2025
Subjects: Uncertainty Quantification
public abstract

description: In recent years, data-driven methods such as deep neural networks (DNNs) have demonstrated remarkable success across various applications. However, these methods often demand a large amount of data to provide accurate predictions, which may be scarce in scientific and engineering problems. In these applications, however, additional information about the system, including physical, constraint, and statistical information, are frequently available and can be harnessed to enhance estimates and facilitate uncertainty quantification.
description: This thesis tackles these challenges by investigating several data-driven approaches for inverse and surrogate modeling problems. Specifically, we present novel methods and applications, including Ensemble Kalman inversion for parameter inference and upstream prediction in rainfall-runoff models, Ensemble Kalman inversion for Bayesian Physics-Informed Neural Networks, and non-negative Gaussian process regression. These approaches capitalize on supplementary information about the systems under study to refine estimates and deliver uncertainty quantification.
description: Collectively, these techniques offer promising directions for data-driven modeling in scientific and engineering applications where direct measurements may be limited and only partially cover the quantities of interest, and where physics, bound, and other indirect information can be employed to bolster estimates and enable uncertainty quantification. The methods introduced in this thesis hold the potential to augment the reliability and accuracy of data-driven models across a diverse range of settings.
Asymptotisch offene Quantensysteme
Creators: name: Westrich, Matthias
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2008
Subjects: thesis
quantum mechanics
field equations: time dependence
algebra: C*
oscillator: harmonic
quantization: Weyl

description: Universität Hamburg, Diplomarbeit, 2008; 90 pp., (2008). doi:10.3204/DESY-THESIS-2008-009
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Boxed Ether
Creators: name: Dzielinski, Jessica
Publisher: name: University of Iowa
Year: 2023
Subjects: Spirituality
public abstract

description: As a kid, my house was one of the first in a build-to-order neighborhood near the Superstition Mountains. A desert home to a variety of deadly animals, centuries of human history and civilization, and a purported portal to hell, now framed by six-lane highways and convenience stores. I would walk around the concrete wall fencing my house to my true backyard- a giant stretch of sand cushioned spaciously between a few surface roads. If I walked out far enough, I would discover old bonfires surrounded by heaps of trash. There were old clothes, toys, cooking supplies, porn magazines- once I even discovered a dilapidated hut. I believed this to be obvious evidence of strange nighttime rituals. There was never anyone there in the day- the trash must have belonged to shadowy figures who only came out at night. I came back almost everyday to investigate and see what new objects might show up. In this process I was at once nervous, desperately fascinated and curious. I would often bring a notepad with me with the intention to record information, regardless of whether or not I actually used it. Exploring this spot was an exercise in searching for stories as well as personal autonomy and freedom. In these moments I was able to deviate from the rules and expectations imposed at home, school, and anywhere else in public. I’m convinced that making art has always been a parallel pursuit. Making art is an endless scavenge- there’s always a libidinous urge to resolve something. The strange thing is, the solution (if there even is one) is only a tiny part of the saga. The intrigue exists in the turmoil, strange events, and minor revelations that occur during the search. I see my work as an artifact of this drama (or non-drama) as well as a re-writing of the story itself.
description: This document is a record outlining the main components of this ongoing investigation. I’ve included images of my own work as well as other artists, spaces, and objects that have supplied inspiration.
3727197.pdf
Creators: name: Boniface, Antoine
name: Gusachenko, Ivan
name: Dholakia, Kishan
name: Gigan, Sylvain
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: ID 346381 - This supplementary materials bring more details on two important points of our manuscript: 1- Hyperspectral imaging calibration and 2- Temporal focusing
Maintaining attention with enhanced human-machine interfaces in conditionally automated driving
Creators: name: Shull, Emily
Publisher: name: University of Iowa
Year: 2023
Subjects: Conditional Automation
Human Factors
Human-Machine Interaction
public abstract

description: Conditionally automated driving systems allow the human operator to disengage from the dynamic driving task (DDT) under certain conditions defined by an operational design domain (ODD). This permits the operator to engage in other non-driving related tasks (NDRT) so long as they remain receptive to a request to intervene (RTI). The transition of control from the automated system to the operator is a highly complex event, requiring the operator to reorient their attention back to the driving environment, regain situation awareness, and takeover within several seconds.
description: Three sets of research studies were conducted to investigate approaches to support the successful transition of control. Success was defined by the reorientation of gaze toward the forward road prior to regaining control as well as taking over within the allotted transition window. The first set of studies investigated how the blanking of a NDRT could support the operator’s disengagement and subsequent reorientation to the driving environment during the transition of control. The second study evaluated how the human-machine interface (HMI) could inform the operator of the automated system’s current confidence before and during a transition of control. Finally, the third set of studies evaluated how the timing and characteristics of the RTI and transition window influenced the transition of control.
description: Time to look up (i.e., reorientation of gaze toward the forward road) and time to takeover (i.e., disengage automated system) were measured across all conditions. Participants were significantly faster to look up after an RTI when a) the NDRT was removed prior to the RTI; b) the automated system informed the operator of its confidence in its operational abilities via the HMI, particularly when paired with an auditory chime; c) the RTI was paired with a brake pulse; and d) the transition window was 4s. Participants were significantly faster to takeover when a) the NDRT was removed prior to the RTI; b) the RTI was paired with a brake pulse; and c) when the transition window duration was 4s compared to 15s.
description: With conditional automation currently in production stages, it is critical that the technologies are designed to best support the operator in reorienting to the driving environment and regaining situation awareness before taking control.
Auditory Mismatch Negativity and Repetition Suppression Deficits in Schizophrenia Explained by Irregular Computation of Prediction Error
Creators: name: Rentzsch, Johannes
name: Shen, Christina
name: Jockers-Scherübl, Maria C.
name: Gallinat, Jürgen
name: Neuhaus, Andres H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The predictive coding model is rapidly gaining attention in schizophrenia research. It posits the neuronal computation of residual variance (‘prediction error’) between sensory information and top-down expectation through multiple hierarchical levels. Event-related potentials (ERP) reflect cortical processing stages that are increasingly interpreted in the light of the predictive coding hypothesis. Both mismatch negativity (MMN) and repetition suppression (RS) measures are considered a prediction error correlates based on error detection and error minimization, respectively. Methods Twenty-five schizophrenia patients and 25 healthy controls completed auditory tasks designed to elicit MMN and RS responses that were investigated using repeated measures models and strong spatio-temporal a priori hypothesis based on previous research. Separate correlations were performed for controls and schizophrenia patients, using age and clinical variables as covariates. Results MMN and RS deficits were largely replicated in our sample of schizophrenia patients. Moreover, MMN and RS measures were strongly correlated in healthy controls, while no correlation was found in schizophrenia patients. Single-trial analyses indicated significantly lower signal-to-noise ratio during prediction error computation in schizophrenia. Conclusions This study provides evidence that auditory ERP components relevant for schizophrenia research can be reconciled in the light of the predictive coding framework. The lack of any correlation between the investigated measures in schizophrenia patients suggests a disruption of predictive coding mechanisms in general. More specifically, these results suggest that schizophrenia is associated with an irregular computation of residual variance between sensory input and top- down models, i.e. prediction error.
The role of prostaglandins in the anti-apoptotic action of transforming growth factor alpha in hen granulosa cells.
Creators: name: Manchanda, Raman.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Cell.

description: Most ($>$99%) ovarian follicles will succumb to atresia via a process known to involve apoptosis of granulosa cells. TGF$\alpha$ is mitogenic in hen granulosa cells and prostaglandins have been shown to mediate the actions of this growth factor in several cell types. The role of non-gonadotropin survival factors (e.g. TGF$\alpha)$ may be crucial in determining the eventual fate of prehierarchal follicles (atresia vs. ovulation). Hematoxylin and eosin stained histological sections of healthy prehierarchal follicles (2-6 mm) appeared to be morphologically unspoiled, round, with intact layers of granulosa cells. In contrast, same size atretic follicles appeared to be morphologically spoiled, with a diminished yolk space containing detached granulosa cells. In situ 3$\sp\prime$-end labelling of DNA in healthy follicles failed to display fragmented DNA in the granulosa or theca layers. However, granulosa cells of atretic follicles stained intensely for fragmented DNA, whereas theca layers showed little or no DNA fragmentation, consistent with the notion that ovarian follicular atresia is linked to apoptosis of granulosa, but not theca cells in vivo. An in vitro cell culture system was used to investigate if TGF$\alpha$ suppresses granulosa cell apoptosis and whether prostaglandins (PGs) mediate the anti-apoptotic action of TGF$\alpha.$ (Abstract shortened by UMI.)