cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Business interest and social policy preference formation: a case study of Thailand
Creators: name: Sungthanu, Nutrawee
Publisher: name: The University of Edinburgh
Year: 2024
Subjects: business
social policy
policy preferences
Thailand
Pracharath

description: This thesis examines why businesses have been engaged with Pracharath Policy for Social Development policy, which is a government-led collaborative policy platform to tackle social problems in Thailand. The study draws upon literature on business interests and social policy, which to date has based largely on the experience of developed countries in the global North. Empirically, the study shows that in the absence of strong pro-welfare actors such as trade unions or left-wing political parties, businesses still support Pracharath for Social Development policy to maintain a reciprocal relationship with the government. Historically, the study presents how Thaksin’s rise to power has changed strategic environments, in which the state, business and the people interact, by challenging old elite establishment, increasing the role of business, and making the people more visible in Thai politics. The research demonstrates that social policies are often used as a political tool to pacify the masses or gain popular support. In the case of Pracharath for Social Development policy, the study argues that business support for this government initiative resembles to a certain extent how businesses support Thaksin’s expansion of welfare polices to prevent social unrest and secure the government’s ruling power as alliance members. Theoretically, the findings accord with the political accommodation thesis, in that business support for social policies is a strategic response to political challenges rather than a reflection of any genuine economic interest in social policy. However, rather than political challenges stemming from class conflict typically observed in countries of the Global North, the research advocates that in the Thai case it is informal institutions - namely elite networks and reciprocal relations - that is the main causal force shaping business policy preferences in Thailand.
Bioreactor concepts for cell culture-based viral vaccine production
Creators: name: Lilí Esmeralda Gallo–Ramírez
name: Nikolay, Alexander
name: Genzel, Yvonne
name: Reichl, Udo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Vaccine manufacturing processes are designed to meet present and upcoming challenges associated with a growing vaccine market and to include multi-use facilities offering a broad portfolio and faster reaction times in case of pandemics and emerging diseases. The final products, from whole viruses to recombinant viral proteins, are very diverse, making standard process strategies hardly universally applicable. Numerous factors such as cell substrate, virus strain or expression system, medium, cultivation system, cultivation method, and scale need consideration. Reviewing options for efficient and economical production of human vaccines, this paper discusses basic factors relevant for viral antigen production in mammalian cells, avian cells and insect cells. In addition, bioreactor concepts, including static systems, single-use systems, stirred tanks and packed-beds are addressed. On this basis, methods towards process intensification, in particular operational strategies, the use of perfusion systems for high product yields, and steps to establish continuous processes are introduced.
Supplementary Methods, Figures and Tables from Age-dependent genetic architecture across ontogeny of body size in sticklebacks
Creators: name: Fraimout, Antoine
name: Li, Zitong
name: Sillanpää, Mikko J.
name: Merilä, Juha
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60408 Genomics

description: Detailed methodology and supplementary figures and tables
The Effort for More Understandable Laws in and at the German Federal Ministry of Justice and Consumer Protection
Creators: name: Schmallenbach, Joline
name: Vogel, Friedemann
Publisher: name: International Journal of Language & Law (JLL)
Year: 2022

description: The article reports on a completed research project on the evaluation of the linguistic legal editorial in the German Federal Ministry of Justice and Consumer Protection (2019-2021). The core objectives of the three-part project were, firstly, the development of a text pragmatic model of criteria for assessing the comprehensibility of norm texts; secondly, the empirical typing of comprehensibility criteria based on a qualitative and quantifying analysis of 50 editorially edited norm texts; thirdly, the empirical survey of reception patterns of norm texts edited by law-editors from the point of view of different recipient groups. The results show that the intensive cooperation of linguistic and legal expertise is both suitable and necessary to make laws more understandable, and thus ultimately makes both legislation and legal practice more efficient. Cite as: Schmallenbach & Vogel, JLL 11 (2022), 18‒35, DOI: 10.14762/jll.2022.018
description: International Journal of Language & Law (JLL), Vol. 11 (2022)
The Debate on 'One Nation, One Language'
Creators: name: Gupta, Garima
Publisher: name: International Journal of Language & Law (JLL)
Year: 2022

description: The debate on ‘one nation, one language’ stems from the idea that India is a nation-state, however, a reality check illustrates the fact that due to the existing political scenario of the world at large, India, although it may be branded as a nation-state as of today, did not start as one, neither during the pre-independence era nor in the post-independence era. The re-cent issues are cropping in and around the language debate in the country, wherein Hindi is ‘being promoted’, basically being a euphemistic expression of ‘being forced’. Imposition of a particular language on the entire geographical stretch of India would result in a new form of imperialism. Meaning thereby, promoting Hindi in the name of national integration and naming it as an ‘official language’ is the first step towards declaring it to be the ‘national lan-guage’. Since India inhabits people of varied linguistic backgrounds having separate dialects and scripts, such action on the part of the government is nothing less than being arbitrary. Cite as: Gupta, JLL 11 (2022), 1-17, DOI: 10.14762/jll.2022.001.
description: International Journal of Language & Law (JLL), Vol. 11 (2022)
Wirksamkeit der Taktplanung aus Perspektive des Bauherrn am Beispiel von Produktionsimmobilien in der Automobilindustrie
Creators: name: Dlouhy, Janosch
Publisher: name: KIT Scientific Publishing
Year: 2022
Subjects: Bau
Takt
Taktplanung
Bauherr
Industriebau
Construction
Taktplanning
Owner

description: Diese Arbeit analysiert den terminlichen Effekt, der durch den Einsatz der Taktplanung im Bauablauf aus Perspektive des Bauherrn auftritt. Es werden Mechanismen zur Manipulation der Projektdurchlaufzeit erarbeitet und weiterführende Wirkungen beschrieben. Für einen sinnvollen Umgang mit den zeitreduzierenden Effekten werden abschließend drei Parameter abgeleitet. Die Erkenntnisse der Arbeit werden in einer Handlungsempfehlung für Bauherren zum Einsatz der Taktplanung zusammengefasst.
D4.5 ARETE Use Scenarios: Analysis of Educational Technologies Usage in Situ – UPDATE
Creators: name: ARETE
Publisher: name: Zenodo
Year: 2022

description: This deliverable D4.5 reports the evaluation methods and results that WP4 has implemented and obtained since the submission of D4.2 in M18. In close collaborations with WP3, WP5 and WP6, the HCI team of WP4 endeavoured to provide timely feedback to the respective teams for improving the interaction quality of the design artefacts generated for the four Pilots. Utilising the established human-centred design methods, we have identified usability problems (UPs). For each UP, we assigned an importance level (low, medium, high) for it to be fixed and proposed recommended modifications for the development team to consider. The table below presents an overview of the evaluation studies undertaken. The design artefacts for each Pilot were at different development stages when under evaluation. The number of usability problems (UPs) varied with the complexity of the software package involved. Specifically, the Pilot 2 package comprised five components - two interactive apps, two workbooks and one map – accounting for a higher number of UPs, albeit the majority was of low importance. Encouragingly, the revised versions of the design artefacts evaluated were found to be more usable and pleasurable to use. Furthermore, WP4 explored the innovative approaches to evaluating eXtended Reality (XR) applications with the wider research community. A workshop was held where emergent XR devices (e.g., smart glasses) and innovative methods (e.g., multisensory fusion) were explored.
description: This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 856533.
FRONTSH1P_D.6.6 Ecodesign case studies CSS4 - Framework for the Ecodesign activities
Creators: name: LNEG
Publisher: name: FRONTSH1P Project
Year: 2023

description: The aim of the Ecodesign approach within the FRONTSH1P project is to identify measures that have the strongest leverage for an environmentally oriented improvement of a product or value chain, which will:• Provide guidelines for LCA and S-LCA, integrating a circular design perspective and needs,• Allow the identification of the circular design strategies, based on a tool developed in a previous project on circular design (the KATCH_e CE Designer tool- www.katche.eu) with more potential for the identified products,• Lead to the identification of improvement opportunities and measures for the strategies – illustrated with examples and case studies.

Additionally, the Ecodesign activity within FRONTSH1P includes structuring the information, data, methodologies, and guidelines to support the development of the tool within WP7.

In view of this, the content of the present document is in accordance with the description of the activity in the Grant Agreement and goes beyond the designation of the respective deliverable.

The methodology used to implement Ecodesign in FRONTSH1P relies on the analysis of value chains involved in the CSS’s, the mapping of environmental, social and economic value losses and the identification of opportunities to capture/recover that value, through the application of Ecodesign strategies and criteria. Five steps are undertaken, using specific templates that were created for each CSS using the ‘Mural’ collaborative platform:• step 1 - the identification of all actors in the CSS’s value chain,• step 2 - the identification of the interactions between them,• step 3 - the identification of value losses (environmental, economic and social),• step 4 - the identification of Ecodesign opportunities based on the losses from step 3,• step 5 - development of guidelines for improvement of the product, service, process and business model.

The resources developed to support the methodology are also presented in this document:• Indicators and data needs,• Checklists for value losses and opportunities identification,• Circular design strategies and criteria,• Examples and case studies,The method is applied and tested to the CSS that is under LNEG’s responsibility (CSS3), given that the Ecodesign team had easier access to more in-depth data and information from coworkers; this activity will be replicated in the other CSS’s.
Conservation genetics of high-arctic Gull species at risk: I. Diversity in the mtDNA control region of circumpolar populations of the Endangered Ivory Gull (Pagophila eburnea)
Creators: name: Royston, Stephanie R.
name: Carr, Steven M.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology

description: The high-arctic Ivory Gull (Pagophila eburnea) has recently undergone a sharp decline in numbers, and in Canada it is listed as “Endangered” under the Species-At-Risk Act. To test for circumpolar genetic distinctiveness, we examined 264 bp of the mtDNA Control Region Domain I from 127 museum specimens collected during the breeding season from northern Canada, Greenland, and Norway, and during the non-breeding season from adjacent overwintering grounds in Canada, Greenland, and a disjunct area in Alaska adjacent to the Bering Sea. Partition of genetic variance according to various phylogeographic and breeding ground models indicates no strong population structure, except that Alaska birds are consistently differentiated from other locations, and there are significant temporal shifts in haplotype frequencies. The evidence suggests that Ivory Gulls in Canada, Greenland, and Norway are a single genetic entity, in contrast to Alaska birds, which may represent a distinctive Siberian population.
Synthesis and characterization of novel organic heteroatom compounds from reaction of Woollins' reagent with various organic substrates
Creators: name: Guoxiong Hua
name: Junyi Du
name: Cordes, David B.
name: Kasun S. A. Arachchige
name: Slawin, Alexandra M. Z.
name: J. Derek Woollins
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology

description: A series of new selenium-containing heteroatom compounds were synthesized in good yields by the reaction of Woollins’ reagent with various organic substrates such as cyclohexylamine, N-benzoylbenzamide, benzoic anhydride, 4-fluoro-N-(2-oxo-2-phenylethyl)benzamide, N-benzoylbenzamide, benzoic anhydride, 3-(bromomethyl)benzonitrile, 1,2-diphenylethane-1,2-diol, and sodium alcoholate. Three representative X-ray structures are described.
Bioreactor concepts for cell culture-based viral vaccine production
Creators: name: Genzel, Yvonne
name: Reichl, Udo
name: Lilí Esmeralda Gallo–Ramírez
name: Nikolay, Alexander
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology
subject: FOS: Biological sciences
subject: Engineering

description: Vaccine manufacturing processes are designed to meet present and upcoming challenges associated with a growing vaccine market and to include multi-use facilities offering a broad portfolio and faster reaction times in case of pandemics and emerging diseases. The final products, from whole viruses to recombinant viral proteins, are very diverse, making standard process strategies hardly universally applicable. Numerous factors such as cell substrate, virus strain or expression system, medium, cultivation system, cultivation method, and scale need consideration. Reviewing options for efficient and economical production of human vaccines, this paper discusses basic factors relevant for viral antigen production in mammalian cells, avian cells and insect cells. In addition, bioreactor concepts, including static systems, single-use systems, stirred tanks and packed-beds are addressed. On this basis, methods towards process intensification, in particular operational strategies, the use of perfusion systems for high product yields, and steps to establish continuous processes are introduced.
Chemistry of Phosphorus Ylides Part 42: Reaction of Dipyridyl Ethanedione with Phosphorus Reagents. Cytotoxic Activity of Phosphanylidene-Cyclobutane, Oxaphosphetane, and Pyridazinone
Creators: name: M. El-Hussieny
name: M. A. Abd-El-Maksoud
name: S. S. Maigali
name: F. M. Soliman
name: A. M. Soliman
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry

description: GRAPHICAL ABSTRACT
YOG'LAR OLINISHI VA XOSSALARI VA YOG'LARDAN SOVUN OLISH
Creators: name: Raxmatova, Zumrat
Publisher: name: Zenodo
Year: 2024

description: Yog‘lar yuqori bir asosli karbon kislotalar bilan uch atomli spirt – glitserindan hosil bo‘lgan murakkab efi rlardir. Bunday birikmalarning umumiy nomi – triglitseridlar. Tabiiy yog‘lar alohida modda emas, balki har xil triglitseridlar aralashmasidir. O‘simlik yog‘i suyuq bo‘ladi va moylar deb ataladi. O‘simlik moylarining tarkibi odatda to‘yinmagan kislotalarning qoldiqlarini o‘z ichiga oladi. O‘simlik moylari suyuq bo‘lishining sababi har bir qo‘shbog‘ning muhiti 6 atomdan iborat qattiq, tekis strukturadir va bunday molekulalar kristall panjaraga yaxshi mos kelmaydi.
GDI Deliverable D8.8 - Evaluation of distributed analysis and federated learning infrastructure solutions and recommendations for adoption
Creators: name: Hernandez-Ferrer, Carles
name: Campos, Dilza
name: Portell-Silva, Laura
name: Capella-Gutierrez, Salvador
Publisher: name: Zenodo
Year: 2024
Subjects: GDI
European Genomic Infrastructure
1+MG
1+Million Genomes Initiative
B1MG
Federated
Infrastructure

description: The completion of the first iteration of the Global Data Initiative technical demonstrators marks a significant milestone in collaborative efforts defining the next level of technologies that will be incorporated into the project. Three key demonstrators showcased advancements in distributed and federated analysis, cancer data mobilisation, and trusted research environments.

Advancements in Distributed and Federated Analysis: The Polygenic Risk Score (PRS) analysis of infectious diseases demonstrated the potential of collaborative frameworks in leveraging disparate datasets while preserving data privacy. Challenges encountered with platforms like Galaxy underscore the need for evolving technologies to facilitate federated analysis seamlessly, which were identified and will be tested on the next iteration of the demonstrator.

Cancer Data Mobilization and Integration: Utilising Galaxy, cBioPortal, and Beacon (v2) highlighted the importance of interoperable platforms in accelerating translational research. Ongoing discussions about platform performance and clinical data harmonisation emphasise the need for interdisciplinary collaboration in refining data management protocols.

Advancements in Trusted Research Environments: The development of a 5-safes RO-Crate compatible Trusted Research Environment laid the foundation for establishing secure and reproducible research infrastructures. Challenges remain in technical capabilities for workflow reproducibility and reutilization.

The successful execution of the three demonstrators underscores multiple collective efforts from different research and knowledge areas. While multiple obstacles were found, strategies to overcome them were found and applied when required and next steps were defined to achieve the goal of each demonstrator.
Werkzeuge und Konzepte für die Untersuchung und Entwicklung zukünftiger Kfz-Bremssysteme
Creators: name: Riese, Christian
Publisher: name: KIT Scientific Publishing
Year: 2022
Subjects: Bremssysteme
hydraulisch
by-Wire
Werkzeuge
Elektromobilität
brake systems
hydraulic
by-wire
tools
electrification

description: Die zunehmende Elektrifizierung des Antriebsstranges sowie die Automatisierung des Fahrens haben erheblichen Einfluss auf zukünftige Fahrwerke. Das regenerative Bremsen durch die E-Maschine führt zu einer Verschiebung des Lastkollektivs, wodurch die ohnehin vorhandene Spreizung bei der Auslegung weiter zunimmt. Um die Wirkzusammenhänge besser zu verstehen und möglichst optimale Systeme für zukünftige Fahrzeuge entwickeln zu können sind entsprechende Werkzeuge und Konzepte notwendig.
Osseointegrated total knee replacement connected to a lower limb prosthesis: 4 cases
Creators: name: Khemka, Aditya
name: Frossard, Laurent
name: J, Sarah
name: Bosley, Belinda
name: Munjed Al Muderis
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Physiology
subject: Medicine
subject: Engineering

description: Background and purpose — Osseointegrated implants are an alternative for prosthetic attachment in individuals with amputation who are unable to wear a socket. However, the load transmitted through the osseointegrated fixation to the residual tibia and knee joint can be unbearable for those with transtibial amputation and knee arthritis. We report on the feasibility of combining total knee replacement (TKR) with an osseointegrated implant for prosthetic attachment.Patients and methods — We retrospectively reviewed all 4 cases (aged 38–77 years) of transtibial amputations managed with osseointegration and TKR in 2012–2014. The below-the-knee prosthesis was connected to the tibial base plate of a TKR, enabling the tibial residuum and knee joint to act as weight-sharing structures. A 2-stage procedure involved connecting a standard hinged TKR to custom-made implants and creation of a skin-implant interface. Clinical outcomes were assessed at baseline and after 1–3 years of follow-up using standard measures of health-related quality of life, ambulation, and activity level including the questionnaire for transfemoral amputees (Q-TFA) and the 6-minute walk test.Results — There were no major complications, and there was 1 case of superficial infection. All patients showed improved clinical outcomes, with a Q-TFA improvement range of 29–52 and a 6-minute walk test improvement range of 37–84 meters.Interpretation — It is possible to combine TKR with osseointegrated implants.
A preprocessing-based planning framework for utilizing contacts in high-precision insertion tasks
Creators: name: Saleem, Muhammad Suhail
name: Veerapaneni, Rishi
name: Likhachev, Maxim
Publisher: name: arXiv
Year: 2024
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: In manipulation tasks like plug insertion or assembly that have low tolerance to errors in pose estimation (errors of the order of 2mm can cause task failure), the utilization of touch/contact modality can aid in accurately localizing the object of interest. Motivated by this, in this work we model high-precision insertion tasks as planning problems under pose uncertainty, where we effectively utilize the occurrence of contacts (or the lack thereof) as observations to reduce uncertainty and reliably complete the task. We present a preprocessing-based planning framework for high-precision insertion in repetitive and time-critical settings, where the set of initial pose distributions (identified by a perception system) is finite. The finite set allows us to enumerate the possible planning problems that can be encountered online and preprocess a database of policies. Due to the computational complexity of constructing this database, we propose a general experience-based POMDP solver, E-RTDP-Bel, that uses the solutions of similar planning problems as experience to speed up planning queries and use it to efficiently construct the database. We show that the developed algorithm speeds up database creation by over a factor of 100, making the process computationally tractable. We demonstrate the effectiveness of the proposed framework in a real-world plug insertion task in the presence of port position uncertainty and a pipe assembly task in simulation in the presence of pipe pose uncertainty.
description: \c{opyright} 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works
OpenAIRE Service Factsheet: Graph V4
Creators: name: Manghi, Paolo
name: Vergoulis, Thanasis
name: Atzori, Claudio
name: Baglioni, Miriam
name: Bardi, Alessia
name: Moura, Paula Cristina Marinho
name: Chatzopoulos, Serafeim
Publisher: name: Zenodo
Year: 2024

description: This factsheet represents the OpenAIRE Graph, a scholarly knowledge graph resulting from the aggregation of metadata records from over 130k data sources which are then further enriched. Funders, organizations, researchers, research communities and publishers can freely use the OpenAIRE Graph to monitor, discover, and navigate the open science record as a whole.
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2–P4 study
Creators: name: Melgious J. Y. Ang
name: Lau, Qiu Ying
name: Fui Mee Ng
name: Siew Wen Then
name: Poulsen, Anders
name: Cheong, Yuen Kuen
name: Ngoh, Zi Xian
name: Tan, Yong Wah
name: Jianhe Peng
name: Keller, Thomas H.
name: Hill, Jeffrey
name: Chu, Justin J. H.
name: C. S. Brian Chia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Biochemistry
subject: Biophysics

description: Enterovirus 71 (EV71) is a highly infectious pathogen primarily responsible for Hand, Foot, and Mouth Disease, particularly among children. Currently, no approved antiviral drug has been developed against this disease. The EV71 3C protease is deemed an attractive drug target due to its crucial role in viral polyprotein processing. Rupintrivir, a peptide-based inhibitor originally developed to target the human rhinovirus 3C protease, was found to inhibit the EV71 3C protease. In this communication, we report the inhibitory activities of 30 Rupintrivir analogs against the EV71 3C protease. The most potent inhibitor, containing a P2 ring-constrained phenylalanine analog (compound 9), was found to be two-fold more potent than Rupintrivir (IC50 value 3.4 ± 0.4 versus 7.3 ± 0.8 μM). Our findings suggest that employing geometrically constrained residues in peptide-based protease inhibitors can potentially enhance their inhibitory activities.
High-throughput selection of human de novo-emerged sORFs with high folding potential
Creators: name: Aubel, Margaux
name: Buchel, Filip
name: Heames, Brennen
name: Jones, Alun
name: Honc, Ondrej
name: Bornberg-Bauer, Erich
name: Hlouchova, Klara
Publisher: name: Zenodo
Year: 2024

description: Abstract:

De novo genes emerge from previously non-coding stretches of the genome. Their encoded de novo proteins are generally expected to be similar to random sequences and, accordingly, with no stable tertiary fold and high predicted disorder. However, structural properties of de novo proteins and whether they differ during the stages of emergence and fixation have not been studied in depth and rely heavily on predictions. Here we generated a library of short human putative de novo proteins of varying lengths and ages and sorted the candidates according to their structural compactness and disorder propensity. Using Förster resonance energy transfer combined with Fluorescence-activated cell sorting we were able to screen the library for most compact protein structures, as well as most elongated and flexible structures. Compact de novo proteins are on average slightly shorter and contain lower predicted disorder than less compact ones. The predicted structures for most and least compact de novo proteins correspond to expectations in that they contain more secondary structure content or higher disorder content, respectively. Our experiments indicate that older de novo proteins have higher compactness and structural propensity compared to young ones. We discuss possible evolutionary scenarios and their implications underlying the age-dependencies of compactness and structural content of putative de novo proteins.

Data:

A full description of the dataset can be found in the README file. Corresponding scripts for the study can be found at https://zivgitlab.uni-muenster.de/ag-ebb/de-novo/fret-facs/
Dehydrative Annulation Strategy for the Construction of Octahydroindolizine Framework: A Diastereoselective Synthesis of (6R,8aS)-Octahydroindolizin-6-ol
Creators: name: Subbarao Jammula
name: Venkateswara Rao Anna
name: Sandip R. Khobare
name: U. K. Syam Kumar
name: Bagineni Prasad
name: Manojit Pal
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Information and Computing Sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry

description: A dehydrative annulation strategy involving an intramolecular ring closure under a Mitsunobu-type reaction condition has been used for the construction of octahydroindolizine framework successfully. This strategy that was reported to be unsuccessful when applied to a similar system allowed us to perform a diastereoselective synthesis of (6R,8aS)-octahydroindolizin-6-ol [a precursor of (–)-8a-epidesacetoxyslaframine] starting from commercially available chiral (S)-epichlorohydrin via a piperidine intermediate, i.e., (3R,6S)-6-(3-hydroxypropyl)piperidin-3-ol. The methodology has potential to afford a library of optically pure small molecules of pharmacological importance based on the related indolizine framework.
Autophagy Supports Color Vision
Creators: name: Zhenqing Zhou
name: Vinberg, Frans
name: Schottler, Frank
name: Doggett, Teresa A
name: Kefalov, Vladimir J
name: Ferguson, Thomas A
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Physiology
subject: Neuroscience
subject: Genetics
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Cones comprise only a small portion of the photoreceptors in mammalian retinas. However, cones are vital for color vision and visual perception, and their loss severely diminishes the quality of life for patients with retinal degenerative diseases. Cones function in bright light and have higher demand for energy than rods; yet, the mechanisms that support the energy requirements of cones are poorly understood. One such pathway that potentially could sustain cones under basal and stress conditions is macroautophagy. We addressed the role of macroautophagy in cones by examining how the genetic block of this pathway affects the structural integrity, survival, and function of these neurons. We found that macroautophagy was not detectable in cones under normal conditions but was readily observed following 24 h of fasting. Consistent with this, starvation induced phosphorylation of AMPK specifically in cones indicating cellular starvation. Inhibiting macroautophagy in cones by deleting the essential macroautophagy gene Atg5 led to reduced cone function following starvation suggesting that cones are sensitive to systemic changes in nutrients and activate macroautophagy to maintain their function. ATG5-deficiency rendered cones susceptible to light-induced damage and caused accumulation of damaged mitochondria in the inner segments, shortening of the outer segments, and degeneration of all cone types, revealing the importance of mitophagy in supporting cone metabolic needs. Our results demonstrate that macroautophagy supports the function and long-term survival of cones providing for their unique metabolic requirements and resistance to stress. Targeting macroautophagy has the potential to preserve cone-mediated vision during retinal degenerative diseases.
Rescaling of the muon content of simulated air showers in the context of the Muon Puzzle
Creators: name: Almeida Cheminant, Kévin
name: Borodai, Nataliia
name: Engel, Ralph
name: Gora, Dariusz
name: Pierog, Tanguy
name: Pękala, Jan
name: Roth, Markus
name: Unger, Michael
name: Veberic, Darko
name: Wilczyński, Henryk
Publisher: name: Scuola Internazionale Superiore di Studi Avanzati (SISSA)
Year: 2025

description: Over the past two decades, multiple astroparticle physics experiments have observed an excess of muons in air shower measurements compared to predictions based on hadronic interaction models calibrated to LHC data. This discrepancy impacts the interpretation of mass composition studies and has deep implications regarding our understanding of hadronic processes at the highest energies. In this work, a Monte Carlo simulation method is proposed, where the longitudinal profiles of simulated and observed air showers are matched in order to estimate the quantity by which the muon content and the Heitler-Matthews β coefficient of a given model must be adjusted to describe the input data. This so-called "Top-Down" method is tested with a mockup dataset composed of air showers simulated at 10 EeV with the Sibyll⋆ model, for different primaries, and reconstructed with the Pierre Auger Observatory software. Assuming the mass composition fraction measured by the Pierre Auger Observatory at this energy for the Sibyll 2.3d model, the quality of the recovery of the muon signal of the mockup dataset is investigated.
Influence of patch size and connectivity on beach and dune species in land-uplift coasts
Creators: name: Tua Nylén
name: Luoto, Miska
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Background: Land-uplift beaches and adjacent dunes contribute considerably to natural diversity. In such fragmented habitat types, the size and connectivity of a habitat patch are hypothesised to strongly influence the distribution of species, particularly the most habitat-specific ones. Aims: To test this hypothesis, our study compared the effects of habitat pattern (patch size and connectivity) and local environmental factors on the distribution and richness of beach species. Methods: We collected extensive observational data on vegetation and environment from beach systems along a 600-km land-uplift gradient on the Baltic Sea coast. The analyses were repeated with three modelling methods to ensure that the results were independent of the selected method. Results and conclusions: Our results indicate that patch size and connectivity influence the occurrence and richness of habitat specialists, while total beach species richness is less dependent on the habitat pattern. Patch size and connectivity are as influential on beach vegetation as local environmental drivers. Unexpectedly, largest patch size or highest connectivity does not appear to maximise species richness or the probability of species occurrence. Instead, the study highlights species-specific responses and the value of also relatively small and isolated habitat patches. Both the diverse network of habitat patches and local environmental variability should be accounted for to efficiently preserve beach species.
Interim Governments: Lessons and Guidelines
Creators: name: Institute for Integrated Transitions
Publisher: name: Zenodo
Year: 2020
Subjects: interim governments
interim government
unelected governments
elected governments
negotiations
constitutional vacuum
practice brief
IFIT
new constitution
economic reform
interim arrangement
institutional stability
crises

description: As seen in recent transition contexts such as Sudan, Pakistan and Haiti, an interim government can serve as an important bridging or stabilising mechanism in times of crisis and dramatic change. 

Interim governments are created under diverse circumstances, including regime collapse, negotiated agreement, special election, or international intervention. They can arise at the national or subnational level, and can have a myriad of compositions: national, international or mixed; one party or power-sharing; civilian, military or hybrid. Their mandates range from providing or restoring basic state services to special tasks such as the preparation of a new constitution or the introduction of economic reform.

This IFIT practice brief focuses exclusively on situations where the interim government is a product of negotiations between two or more political actors transitioning out of a severe crisis, armed conflict or authoritarian regime. It offers practical recommendations for policymakers on the two central dimensions of negotiated interim governments: composition and mandate.
Influence of patch size and connectivity on beach and dune species in land-uplift coasts
Creators: name: Tua Nylén
name: Luoto, Miska
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Background: Land-uplift beaches and adjacent dunes contribute considerably to natural diversity. In such fragmented habitat types, the size and connectivity of a habitat patch are hypothesised to strongly influence the distribution of species, particularly the most habitat-specific ones. Aims: To test this hypothesis, our study compared the effects of habitat pattern (patch size and connectivity) and local environmental factors on the distribution and richness of beach species. Methods: We collected extensive observational data on vegetation and environment from beach systems along a 600-km land-uplift gradient on the Baltic Sea coast. The analyses were repeated with three modelling methods to ensure that the results were independent of the selected method. Results and conclusions: Our results indicate that patch size and connectivity influence the occurrence and richness of habitat specialists, while total beach species richness is less dependent on the habitat pattern. Patch size and connectivity are as influential on beach vegetation as local environmental drivers. Unexpectedly, largest patch size or highest connectivity does not appear to maximise species richness or the probability of species occurrence. Instead, the study highlights species-specific responses and the value of also relatively small and isolated habitat patches. Both the diverse network of habitat patches and local environmental variability should be accounted for to efficiently preserve beach species.
Streamlining (Meta)Data Management and Submission to Repositories
Creators: name: D'Anna, Flora
name: Droesbeke, Bert
Publisher: name: Zenodo
Year: 2024
Subjects: ENA
data submission
brokering
genomics data
publishing data
Omics data
data deposition

description: Presentation given at Empowering Biodiversity Research III on the 26th of March 2024, Leiden
Routing Algorithm for Software Defined Network Based on Boxcovering Algorithm
Creators: name: Turlykozhayeva, Dana
name: Akhtanov, Sayat
name: Ussipov, Nurzhan
name: Akhmetali, Almat
name: Bolysbay, Aslan
name: Shabdan, Yerkin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: A routing algorithm is the most fundamental problem in complex network communication. In complex networks, the amount of computation increases as the number of nodes increases which reduces routing performance. In this paper, we propose a routing algorithm for software-defined networking (SDN) based on a box-covering (BC) algorithm. It is known that using the BC algorithm it is possible to increase performance in complex SDN. We partition the entire SDN network into subnets using three existing box-covering methods such as MEMB, GC, and CIEA, then we use Dijkstra\textquotesingle s algorithm to find the shortest path between subnets and within each subnet. We compared all box-covering algorithms and found that the GC algorithm has the highest performance for SDN routing.
description: 2023 10th International Conference on Wireless Networks and Mobile Communications (WINCOM)
The first reported outbreak of equine herpesvirus myeloencephalopathy in New Zealand
Creators: name: AMJ McFadden
name: D Hanlon
name: RK McKenzie
name: I Gibson
name: IM Bueno
name: DJ Pulford
name: D Orr
name: M Dunowska
name: WL Stanislawek
name: RP Spence
name: WL McDonald
name: G Munro
name: IG Mayhew
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: CASE HISTORY AND CLINICAL FINDINGS: On 9 January 2014 (Day 0) a mare from a stud farm in the Waikato region presented with urinary incontinence without pyrexia. Over the following 33 days 15 mares were clinically affected with neurological signs. All but one mare had a foal at foot. The most commonly observed clinical signs were hind limb paresis and ataxia. In some cases recumbency occurred very early in the course of disease and seven mares were subject to euthanasia for humane reasons. LABORATORY FINDINGS: Equid herpesvirus (EHV) type 1 was detected using PCR in various tissues collected post mortem from two mares with neurological signs. DNA sequencing data from the DNA polymerase gene of the virus showed a nucleotide transition at position 2254, a mutation encoding amino acid D752 that is highly associated with the neuropathogenic genotype of EHV-1. In total 12/15 mares were confirmed positive for EHV-1 on PCR. Results from a virus neutralisation test and ELISA on paired serum samples, and PCR on whole blood and nasal swabs, indicated that of four paddocks in a high-risk area where a cluster of cases had occurred, 20/21 (95%) horses were likely to have been exposed or were confirmed infected with EHV-1. Subsequent to the outbreak two mares aborted, one at 9 months and one at 10 months of gestation. The cause of abortion was confirmed as EHV-1 with the same genotype as that involved in the outbreak. DIAGNOSIS: Equine herpesvirus myeloencephalopathy. CLINICAL RELEVANCE: The outbreak described shows the considerable impact that can occur in outbreaks of equine herpesvirus myeloencephalopathy in New Zealand. Early biosecurity controls not only reduced the effect on the farm but mitigated the potential for the virus to spread to other horse enterprises.
Growth without growth hormone: can growth and differentiation factor 5 be the mediator?
Creators: name: Biana Shtaif
name: Dror, Nitzan
name: Meytal Bar-Maisels
name: Phillip, Moshe
name: Gat-Yablonski, Galia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Biotechnology
subject: Physiology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: Growth without growth hormone (GH) is often observed in the setup of obesity; however, the missing link between adipocytes and linear growth was until now not identified. 3T3L1 cells were induced to differentiate into adipocytes and their conditioned medium (CM) (adipocytes CM, CMA) was added to metatarsals bone culture and compared to CM derived from undifferentiated cells. CMA significantly increased metatarsals bone elongation. Adipogenic differentiation increased the expression of growth and differentiation factor (GDF)-5, also found to be secreted into the CMA. GDF-5 significantly increased metatarsal length in culture; treatment of the CMA with anti-GDF-5 antibody significantly reduced the stimulatory effect on bone length. The presence of GDF-5 receptor (bone morphogenetic protein receptor; BMPR1) in metatarsal bone was confirmed by immunohistochemistry. Animal studies in rodents subjected to food restriction followed by re-feeding showed an increase in GDF-5 serum levels concomitant with nutritional induced catch up growth. These results show that adipocytes may stimulate bone growth and suggest an additional explanation to the growth without GH phenomenon.
Enhancing Adversarial Transferability via Information Bottleneck Constraints
Creators: name: Qi, Biqing
name: Gao, Junqi
name: Liu, Jianxing
name: Wu, Ligang
name: Zhou, Bowen
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: From the perspective of information bottleneck (IB) theory, we propose a novel framework for performing black-box transferable adversarial attacks named IBTA, which leverages advancements in invariant features. Intuitively, diminishing the reliance of adversarial perturbations on the original data, under equivalent attack performance constraints, encourages a greater reliance on invariant features that contributes most to classification, thereby enhancing the transferability of adversarial attacks. Building on this motivation, we redefine the optimization of transferable attacks using a novel theoretical framework that centers around IB. Specifically, to overcome the challenge of unoptimizable mutual information, we propose a simple and efficient mutual information lower bound (MILB) for approximating computation. Moreover, to quantitatively evaluate mutual information, we utilize the Mutual Information Neural Estimator (MINE) to perform a thorough analysis. Our experiments on the ImageNet dataset well demonstrate the efficiency and scalability of IBTA and derived MILB. Our code is available at https://github.com/Biqing-Qi/Enhancing-Adversarial-Transferability-via-Information-Bottleneck-Constraints.