cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EML4 promotes the loading of NUDC to the spindle for mitotic progression
Creators: name: Chen, Dan
name: Ito, Satoko
name: Yuan, Hong
name: Hyodo, Toshinori
name: Kadomatsu, Kenji
name: Michinari Hamaguchi
name: Senga, Takeshi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: Echinoderm microtubule-associated protein (EMAP)-like (EML) family proteins are microtubule-associated proteins that have a conserved hydrophobic EMAP-like protein (HELP) domain and multiple WD40 domains. In this study, we examined the role of EML4, which is a member of the EML family, in cell division. Time-lapse microscopy analysis demonstrated that EML4 depletion induced chromosome misalignment during metaphase and delayed anaphase initiation. Further analysis by immunofluorescence showed that EML4 was required for the organization of the mitotic spindle and for the proper attachment of kinetochores to microtubules. We searched for EML4-associating proteins by mass spectrometry analysis and found that the nuclear distribution gene C (NUDC) protein, which is a critical factor for the progression of mitosis, was associated with EML4. This interaction was mediated by the WD40 repeat of EML4 and by the C-terminus of NUDC. In the absence of EML4, NUDC was no longer able to localize to the mitotic spindle, whereas NUDC was dispensable for EML4 localization. Our results show that EML4 is critical for the loading of NUDC onto the mitotic spindle for mitotic progression.
p38/p53/miR-200a-3p feedback loop promotes oxidative stress-mediated liver cell death
Creators: name: Yongtao Xiao
name: Weihui Yan
name: Lu, Lina
name: Wang, Ying
name: Lu, Wei
name: Cao, Yi
name: Cai, Wei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Marine Biology
subject: Biological Sciences
subject: Chemistry
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Biochemistry
subject: Biophysics

description: Although our previous studies have provided evidence that oxidative stress has an essential role in total parenteral nutrition (TPN)-associated liver injury, the mechanisms involved are incompletely understood. Here, we show the existence of crosstalk between the miR-200 family of microRNAs and oxidative stress. The members of the miR-200 family are markedly enhanced in hepatic cells by hydrogen peroxide (H2O2) treatment. The upregulation of miR-200-3p in turn modulates the H2O2-mediated oxidative stress response by targeting p38α. The enhanced expression of miR-200-3p mimics p38α deficiency and promotes H2O2-induced cell death. Members of the miR-200 family that are known to inhibit the epithelial to mesenchymal transition (EMT) are induced by the tumour suppressor p53. Here, we show that p53 phosphorylation at Ser 33 contributes to H2O2-induced miR-200s transcription. In addition, we show that p38α can directly phosphorylate p53 at serine 33 upon H2O2 exposure. Thus, we suggest that in liver cells, the oxidative stress-induced, p38α-mediated phosphorylation of p53 at Ser33 is essential for the functional regulation of oxidative stress-induced miR-200 transcription by p53. Collectively, our data indicate that the p53-dependent expression of miR-200a-3p promotes cell death by inhibiting a p38/p53/miR-200 feedback loop.
Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes
Creators: name: Zhang, Liang
name: Longsen Han
name: Rujun Ma
name: Xiaojing Hou
name: Yu, Yang
name: Shaochen Sun
name: Yinxue Xu
name: Schedl, Tim
name: Kelle H Moley
name: Wang, Qiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Maternal obese environment has been reported to induce oxidative stress and meiotic defects in oocytes, however the underlying molecular mechanism remains unclear. Here, using mice fed a high fat diet (HFD) as an obesity model, we first detected enhanced reactive oxygen species (ROS) content and reduced Sirt3 expression in HFD oocytes. We further observed that specific depletion of Sirt3 in control oocytes elevates ROS levels while Sirt3 overexpression attenuates ROS production in HFD oocytes, with significant suppression of spindle disorganization and chromosome misalignment phenotypes that have been reported in the obesity model. Candidate screening revealed that the acetylation status of lysine 68 on superoxide dismutase (SOD2K68) is dependent on Sirt3 deacetylase activity in oocytes, and acetylation-mimetic mutant SOD2K68Q results in almost threefold increase in intracellular ROS. Moreover, we found that acetylation levels of SOD2K68 are increased by ˜80% in HFD oocytes and importantly, that the non-acetylatable-mimetic mutant SOD2K68R is capable of partially rescuing their deficient phenotypes. Together, our data identify Sirt3 as an important player in modulating ROS homeostasis during oocyte development, and indicate that Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress and meiotic defects in oocytes under maternal obese conditions.
Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes
Creators: name: Zhang, Liang
name: Longsen Han
name: Rujun Ma
name: Xiaojing Hou
name: Yu, Yang
name: Shaochen Sun
name: Yinxue Xu
name: Schedl, Tim
name: Kelle H Moley
name: Wang, Qiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Maternal obese environment has been reported to induce oxidative stress and meiotic defects in oocytes, however the underlying molecular mechanism remains unclear. Here, using mice fed a high fat diet (HFD) as an obesity model, we first detected enhanced reactive oxygen species (ROS) content and reduced Sirt3 expression in HFD oocytes. We further observed that specific depletion of Sirt3 in control oocytes elevates ROS levels while Sirt3 overexpression attenuates ROS production in HFD oocytes, with significant suppression of spindle disorganization and chromosome misalignment phenotypes that have been reported in the obesity model. Candidate screening revealed that the acetylation status of lysine 68 on superoxide dismutase (SOD2K68) is dependent on Sirt3 deacetylase activity in oocytes, and acetylation-mimetic mutant SOD2K68Q results in almost threefold increase in intracellular ROS. Moreover, we found that acetylation levels of SOD2K68 are increased by ∼80% in HFD oocytes and importantly, that the non-acetylatable-mimetic mutant SOD2K68R is capable of partially rescuing their deficient phenotypes. Together, our data identify Sirt3 as an important player in modulating ROS homeostasis during oocyte development, and indicate that Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress and meiotic defects in oocytes under maternal obese conditions.
Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes
Creators: name: Zhang, Liang
name: Longsen Han
name: Rujun Ma
name: Xiaojing Hou
name: Yu, Yang
name: Shaochen Sun
name: Yinxue Xu
name: Schedl, Tim
name: Kelle H Moley
name: Wang, Qiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Maternal obese environment has been reported to induce oxidative stress and meiotic defects in oocytes, however the underlying molecular mechanism remains unclear. Here, using mice fed a high fat diet (HFD) as an obesity model, we first detected enhanced reactive oxygen species (ROS) content and reduced Sirt3 expression in HFD oocytes. We further observed that specific depletion of Sirt3 in control oocytes elevates ROS levels while Sirt3 overexpression attenuates ROS production in HFD oocytes, with significant suppression of spindle disorganization and chromosome misalignment phenotypes that have been reported in the obesity model. Candidate screening revealed that the acetylation status of lysine 68 on superoxide dismutase (SOD2K68) is dependent on Sirt3 deacetylase activity in oocytes, and acetylation-mimetic mutant SOD2K68Q results in almost threefold increase in intracellular ROS. Moreover, we found that acetylation levels of SOD2K68 are increased by ∼80% in HFD oocytes and importantly, that the non-acetylatable-mimetic mutant SOD2K68R is capable of partially rescuing their deficient phenotypes. Together, our data identify Sirt3 as an important player in modulating ROS homeostasis during oocyte development, and indicate that Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress and meiotic defects in oocytes under maternal obese conditions.
title: Séquence pédagogique à visée égalitaire filles-garçons pour des élèves de 2P
title: Séquence pédagogique à visée égalitaire filles-garçons pour des élèves de 2P
titleType: AlternativeTitle
Creators: name: Honegger, Damini
name: Lutz, Garance
Publisher: name: Unknown
Year: 0
Subjects: subject: genre
subject: socialisation genrée
subject: stéréotypes de genre
subject: séquence pédagogique à visée égalitaire
subject: élèves de 5-6 ans

description: Les hommes, au même titre que les femmes, ont le droit d’être sensibles. Les hommes, tout comme les femmes, devraient se sentir libres d’être forts… Il est grand temps que nous appréhendions l’égalité comme un spectre, au lieu d’y voir deux idéaux distincts et opposés. (Watson, 2014) Différentes autrices et auteurs mettent en évidence la présence d’une socialisation différenciée qui s’opère entre les deux sexes. En effet, dès la naissance, l’individu connaît un apprentissage qui engendre des conséquences dont notamment sur le développement de ses compétences ainsi que sur sa personnalité. Ainsi, nous décidons de réaliser une séquence pédagogique à visée égalitaire filles-garçons pour des élèves de 2P. Notre question de recherche se formule donc ainsi : Comment réaliser une séquence pédagogique à visée égalitaire filles-garçons pour des élèves de 2P ? Il est question de réfléchir aux modalités et contenus pédagogiques qui permettent de mobiliser de si jeunes élèves pour les amener à formuler leur pensée en écoutant l’avis des autres et en émettant une opinion, en regard des exigences du Plan d’études romand. Notre séquence pédagogique se compose de cinq activités touchant divers domaines : les traits physiques, les métiers, les jouets/jeux et les sacs d’école. Pendant leur réalisation, les propos des élèves sont enregistrés ; ils constituent nos données pour l’analyse. Il apparaît, au travers de notre recherche, que pareil dispositif porte ses fruits, ce qui devrait constituer une forme d’encouragement pour les professionnel·le·s du premier cycle primaire à mener des activités à visée égalitaire afin d’ouvrir le champ des possibles aux élèves.
title: Thermal radiation processes
Creators: name: Kaastra, Jelle S.
name: Paerels, Frits B.S.
name: Durret, Florence
name: Schindler, Sabine
name: Richter, Philipp
Publisher: name: Universität Potsdam
Year: 2020

description: We discuss the different physical processes that are important to understand the thermal X-ray emission and absorption spectra of the diffuse gas in clusters of galaxies and the warm-hot intergalactic medium. The ionisation balance, line and continuum emission and absorption properties are reviewed and several practical examples are given that illustrate the most important diagnostic features in the X-ray spectra.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 891
title: Towards the assimilation of tree-ring-width records using ensemble Kalman filtering techniques
Creators: name: Acevedo, Walter
name: Reich, Sebastian
name: Cubasch, Ulrich
Publisher: name: Universität Potsdam
Year: 2020

description: This paper investigates the applicability of the Vaganov–Shashkin–Lite (VSL) forward model for tree-ring-width chronologies as observation operator within a proxy data assimilation (DA) setting. Based on the principle of limiting factors, VSL combines temperature and moisture time series in a nonlinear fashion to obtain simulated TRW chronologies. When used as observation operator, this modelling approach implies three compounding, challenging features: (1) time averaging, (2) “switching recording” of 2 variables and (3) bounded response windows leading to “thresholded response”. We generate pseudo-TRW observations from a chaotic 2-scale dynamical system, used as a cartoon of the atmosphere-land system, and attempt to assimilate them via ensemble Kalman filtering techniques. Results within our simplified setting reveal that VSL’s nonlinearities may lead to considerable loss of assimilation skill, as compared to the utilization of a time-averaged (TA) linear observation operator. In order to understand this undesired effect, we embed VSL’s formulation into the framework of fuzzy logic (FL) theory, which thereby exposes multiple representations of the principle of limiting factors. DA experiments employing three alternative growth rate functions disclose a strong link between the lack of smoothness of the growth rate function and the loss of optimality in the estimate of the TA state. Accordingly, VSL’s performance as observation operator can be enhanced by resorting to smoother FL representations of the principle of limiting factors. This finding fosters new interpretations of tree-ring-growth limitation processes.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 892
Additional file 1 of Supported employment for people with severe mental illness: a pilot study of an Italian social enterprise with a special ingredient
Creators: name: Martinelli, Alessandra
name: Bonetto, Chiara
name: Bonora, Federica
name: Cristofalo, Doriana
name: Killaspy, Helen
name: Ruggeri, Mirella
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Brief von Carl Heymann, Adolf Asher, Jacob Moses Burg, Harry Jacob und Munk von Jüdische Gemeinde zu Berlin. Vorstand an Leopold Zunz, 17.02.1850
Creators: name: (:Unkn) Unknown
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1850
Subjects: subject: 090

description: Entwurf und Bitte um Zusammenarbeit für eine Denkschrift, die an alle jüdischen Gemeinden Deutschlands geschickt werden sollte, um sie zum Beitritt zu einer Zentralbehörde für die Angelegenheiten der jüdischen Gemeinden zu bewegen
Aprendendo com Amor: Afetividade e Educação na Infância
Creators: name: Santos, Amanda dos Santos
name: Menezes, Dalva de Araujo
Publisher: name: Zenodo
Year: 2023

description: As relações afetivas na escola são de fundamental importância na aprendizagem das crianças da educação infantil, tendo em vista que elas começam na primeira infância e vai sendo construída durante toda a vida. As atitudes afetivas entre professor e aluno despertam e contribuem de forma significante para aprendizagem, oferecendo desempenho intelectual, pessoal e social.
Tendo em vista os problemas que afetam o dia a dia escolar, tais como, indisciplina, agressão física e verbal dentro das salas de aula, estão sendo estudados como conceitos relacionados à falta de afetividade docente, surge então, a necessidade de investigar como essas relações afetivas entre professores e alunos podem melhorar o aprendizado, este trabalho poderá contribuir para esclarecer o papel da afetividade na melhoria do ensino e aprendizagem.
Therapeutic potential of mitotic interaction between the nucleoporin Tpr and Aurora kinase A
Creators: name: Kobayashi, Akiko
name: Hashizume, Chieko
name: Dowaki, Takayuki
name: Wong, Richard W
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Spindle poles are defined by centrosomes; therefore, an abnormal number or defective structural organization of centrosomes can lead to loss of spindle bipolarity and genetic integrity. Previously, we showed that Tpr (translocated promoter region), a component of the nuclear pore complex (NPC), interacts with Mad1 and dynein to promote proper chromosome segregation during mitosis. Tpr also associates with p53 to induce autophagy. Here, we report that Tpr depletion induces mitotic catastrophe and enhances the rate of tetraploidy and polyploidy. Mechanistically, Tpr interacts, via its central domain, with Aurora A but not Aurora B kinase. In Tpr-depleted cells, the expression levels, centrosomal localization and phosphorylation of Aurora A were all reduced. Surprisingly, an Aurora A inhibitor, Alisertib (MLN8237), also disrupted centrosomal localization of Tpr and induced mitotic catastrophe and cell death in a time- and dose-dependent manner. Strikingly, over-expression of Aurora A disrupted Tpr centrosomal localization only in cells with supernumerary centrosomes but not in bipolar cells. Our results highlight the mutual regulation between Tpr and Aurora A and further confirm the importance of nucleoporin function in spindle pole organization, bipolar spindle assembly, and mitosis; functions that are beyond the conventional nucleocytoplasmic transport and NPC structural roles of nucleoporins. Furthermore, the central coiled-coil domain of Tpr binds to and sequesters extra Aurora A to safeguard bipolarity. This Tpr domain merits further investigation for its ability to inhibit Aurora kinase and as a potential therapeutic agent in cancer treatment.
The American Dream Its Echoes and Possibilities in Literary Discourse.pdf
Creators: name: Kalu, Kalu  Obasi
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 470501
subject: African literature

description: The American Dream stems from the inaugural speech of President Franklin Roosevelt's "Four Freedoms" (1941).
The Four Freedoms envisage an American society where the freedom of worship, freedom of speech, freedom of movement, and the right to life are enshrined, guaranteed, and accommodated. America has been clouded with numerous yearnings from all angles - politics, academic, economic, among other social upheavals, for the enthronement of the Four Freedoms. Literary scholars have diminutively expressed the horrors of African Americans in various forms and shades, and have hopefully waited for the day it will be implemented. This paper attempts to relay the horrors, echoes, and possibilities of the American Dream as expressed by literary scholars and the mass media. It also attempts to unveil the measures the African Americans have taken to live in the face of the horrors that have affected their existence among the White Americans. The possibilities of their struggles to live above subjugations, oppressions, the Jim Crow Laws, and racial discrimination that have rocked the American society for decades are also within the wavelength of this work.
Keywords: The American Dream, Echoes, Possibilities, Literary discourse affected
Synergistic Combination of Vasculature Disrupting Agent with TLR7/8 Agonist: Promising Strategy for Melanoma Therapy
Creators: name: Seth, Anushree
name: Hyunseung  Lee
name: Cheongsoo  Park
name: Joo-Yong  Lee
name: Hong, Kwan Soo
Publisher: name: F1000 Research Limited
Year: 2020

description: Gardiquimod is an imidazoquinoline compound and is a potent toll-like receptor 7 and 8 (TLR7/8) agonist. It causes activation of innate immune response and is known to have potent anti-viral and anti-tumor effect [1, 2]. It activates NFκB and MAP kinase pathways in innate immune cells and is speculated to stimulate antigen presenting cells (APCs) which were rendered tolerant in immuno-suppressed tumor microenvironment. 5,6-Dimethylxanthenone- 4-acetic Acid (DMXAA) exerts its anti-tumor effect by disrupting the tumor vasculature leading to generation of a necrotic center in a solid tumor. However, the limitation with DMXAA treatment is that the tumor cells present in the periphery are unaffected by the drug, leading to incomplete therapy. In this research, combination of gardiquimod with DMXAA was assessed to target B16 melanoma in a mouse model. Uniform and spherical gardiquimod encapsulated PLGA nanoparticles were prepared using single emulsion method. Their size was ∼193 nm and the encapsulation efficiency was found to be 11.4 µg/mg. The role of nanoparticulate formulation was assessed by observing improved activation of BMDCs in the presence of PLGA-gardiquimod as compared to free gardiquimod. The nanoparticle uptake by BMDCs was also confirmed by fluorescence imaging. Further, PLGA-gardiquimod and DMXAA in the ratio of 1:10, 1:100, 1:200 and 1:500 synergistically enhanced cytokine (TNFα and IL-12) secretion from BMDCs. Mice treated with the combination had significantly lower tumor volume and a higher survival rate as compared to control groups, which was also in good correlation with immuno-chemical analyses from tumor tissue samples. This research highlights combination of vasculature disrupting with immuno-stimulation as a promising approach for management of solid tumor.
Additional file 1 of MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis
Creators: name: Raji, Sara
name: Sahranavard, Mehrdad
name: Mottaghi, Mahdi
name: Sahebkar, Amirhossein
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1: Detailed search strategy.
Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A
Creators: name: Kobayashi, Akiko
name: Hashizume, Chieko
name: Dowaki, Takayuki
name: Wong, Richard W
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Spindle poles are defined by centrosomes; therefore, an abnormal number or defective structural organization of centrosomes can lead to loss of spindle bipolarity and genetic integrity. Previously, we showed that Tpr (translocated promoter region), a component of the nuclear pore complex (NPC), interacts with Mad1 and dynein to promote proper chromosome segregation during mitosis. Tpr also associates with p53 to induce autophagy. Here, we report that Tpr depletion induces mitotic catastrophe and enhances the rate of tetraploidy and polyploidy. Mechanistically, Tpr interacts, via its central domain, with Aurora A but not Aurora B kinase. In Tpr-depleted cells, the expression levels, centrosomal localization and phosphorylation of Aurora A were all reduced. Surprisingly, an Aurora A inhibitor, Alisertib (MLN8237), also disrupted centrosomal localization of Tpr and induced mitotic catastrophe and cell death in a time- and dose-dependent manner. Strikingly, over-expression of Aurora A disrupted Tpr centrosomal localization only in cells with supernumerary centrosomes but not in bipolar cells. Our results highlight the mutual regulation between Tpr and Aurora A and further confirm the importance of nucleoporin function in spindle pole organization, bipolar spindle assembly, and mitosis; functions that are beyond the conventional nucleocytoplasmic transport and NPC structural roles of nucleoporins. Furthermore, the central coiled-coil domain of Tpr binds to and sequesters extra Aurora A to safeguard bipolarity. This Tpr domain merits further investigation for its ability to inhibit Aurora kinase and as a potential therapeutic agent in cancer treatment.
Additional file 1 of Development and validation of the oral presentation evaluation scale (OPES) for nursing students
Creators: name: Chiang, Yi-Chien
name: Lee, Hsiang-Chun
name: Chu, Tsung-Lan
name: Wu, Chia-Ling
name: Hsiao, Ya-Chu
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1.
Γάμος και Θάνατος: οι περιπτώσεις της Δηιάνειρας, της Άλκηστης και της Ευάδνης
Creators: name: Μπέκα, Σεβαστή Χρήστου
Publisher: name: Aristotle University of Thessaloniki
Year: 2022
Subjects: αρχαία ελληνική τραγωδία
γυναίκες
γάμος-θάνατος
ancient Greek tragedy
women
marriage-death

description: Αφορμώμενη από το συχνό στην τραγωδία μοτίβο “γάμος-θάνατος”, που βασίζεται στα κοινά στοιχεία που εντοπίζονται στα τελετουργικά του γάμου και της κηδείας και στον διαβατήριο χαρακτήρα των δύο καταστάσεων, η παρούσα διπλωματική εργασία εστιάζει σε τρεις παντρεμένες ηρωίδες, στη Δηιάνειρα, την Ευάδνη και την Άλκηστη, και αποτυπώνει τον τρόπο με τον οποίο οι αρνητικές συγκυρίες και συμφορές που κάθε μια βιώνει στον γάμο της οδηγούν στον θάνατό της, με τον σύζυγο να παίζει καταλυτικό ρόλο σε αυτόν. Ομοιότητες εντοπίζονται αναφορικά τόσο με τα κίνητρα που ωθούν τις γυναίκες αυτές στην απόφασή τους να πεθάνουν, όσο και με τα στοιχεία εκείνα που επιβεβαιώνουν τη διαπλοκή του γάμου και του θανάτου σε επίπεδο γλώσσας, τελετουργίας και επιμέρους συμβολισμών, ενώ ιδιαίτερη έμφαση δίνεται στη στιγμή του θανάτου των ηρωίδων, η οποία και στις τρεις περιπτώσεις παραπέμπει στο γαμήλιο τελετουργικό και στην αναβίωση της γαμήλιας νύχτας. Επιπλέον, προβληματισμός τίθεται και σχετικά με τη φήμη -και κατ’ επέκταση με τη δόξα- που θεωρείται πως αποκτούν οι ηρωίδες μέσω του θανάτου τους. Τέλος, επιχειρείται να δοθεί μια ερμηνεία σχετικά με την λειτουργία του θέματος της διαπλοκής του γάμου και του θανάτου στο κάθε έργο
description: Prompted by the frequent “marriage – death” motif in tragedy, which is based on the common elements found in the rituals of wedding and funeral, and the transitional nature of the two situations, this dissertation focuses on three married heroines (Deianeira, Evadne and Alcestis) and reflects how the negative circumstances and misfortunes that each one experiences in her marriage lead to her death, which is catalyzed by her husband. Parallels are detected with regard to the motivations that prompt these women to die, as well as to those elements that confirm the association of marriage and death on a linguistic, ceremonial and individual symbolic level, while the moment of the heroines’ death (which in all cases resembles the wedding ritual and the revival of the wedding night) is particularly emphasized. Furthermore, emphasis is laid on the acquired fame (and, by extension, on glory) that emerges as a result of the heroines’ deaths. Last but not least, an interpretative attempt is made, concerning the function of the “marriage – death” theme in each work
Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A
Creators: name: Kobayashi, Akiko
name: Hashizume, Chieko
name: Dowaki, Takayuki
name: Wong, Richard W
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Spindle poles are defined by centrosomes; therefore, an abnormal number or defective structural organization of centrosomes can lead to loss of spindle bipolarity and genetic integrity. Previously, we showed that Tpr (translocated promoter region), a component of the nuclear pore complex (NPC), interacts with Mad1 and dynein to promote proper chromosome segregation during mitosis. Tpr also associates with p53 to induce autophagy. Here, we report that Tpr depletion induces mitotic catastrophe and enhances the rate of tetraploidy and polyploidy. Mechanistically, Tpr interacts, via its central domain, with Aurora A but not Aurora B kinase. In Tpr-depleted cells, the expression levels, centrosomal localization and phosphorylation of Aurora A were all reduced. Surprisingly, an Aurora A inhibitor, Alisertib (MLN8237), also disrupted centrosomal localization of Tpr and induced mitotic catastrophe and cell death in a time- and dose-dependent manner. Strikingly, over-expression of Aurora A disrupted Tpr centrosomal localization only in cells with supernumerary centrosomes but not in bipolar cells. Our results highlight the mutual regulation between Tpr and Aurora A and further confirm the importance of nucleoporin function in spindle pole organization, bipolar spindle assembly, and mitosis; functions that are beyond the conventional nucleocytoplasmic transport and NPC structural roles of nucleoporins. Furthermore, the central coiled-coil domain of Tpr binds to and sequesters extra Aurora A to safeguard bipolarity. This Tpr domain merits further investigation for its ability to inhibit Aurora kinase and as a potential therapeutic agent in cancer treatment.
PRAKTIKUM I DIVISI PINOPHYTA
Creators: name: Miftahur Rahmah
Publisher: name: Zenodo
Year: 2020

description: Assalamu'alaikum wr.wb Dikarena ada ke salahan pada daftar pustaka, laporan ini adalah laporan praktikum 1 yang telah di revisi daftar pustakanya Terima kasih.
title: In Her Place: Addressing Women’s Equity Through Evidence-Based Planning Practice
Creators: name: Agnello, Kristin
Publisher: name: Vancouver Island University
Year: 2024
Subjects: College of interdisciplinary studies

description: 2024
description: This research examines how urban planners can better understand and improve gender-based interventions and address the individual, institutional, and systemic biases that have contributed to women’s inequality in the urban environment through data-driven analysis and evaluation. Rooted in a pragmatic, social constructionist theoretical perspective, this research acknowledges that lived experience is intrinsically linked to both knowledge about and action relating to the socio-spatial environment. A portfolio of three, interrelated scholarly works – woven together by themes of evidence-based decision-making, systems thinking, and personal and professional reflexivity – demonstrates a multilevel approach to addressing women’s equity through planning practice. The portfolio components include: (1) a published, co-authored journal article describing how a systematic review methodology can be modified to support informed decision-making in planning practice; (2) a sole-authored journal article exploring the role of, and relationships between, multilevel, gender-based planning instruments within an overarching theory of change; and (3) an academic book proposal providing evidence of the disparate impacts of gender-based planning interventions on a diverse population and providing recommendations for addressing individual and systemic bias in planning practice. By devoting attention – and intention – to understanding the roles and impacts of planning instruments, institutional structures, and personal biases on women’s equity, this portfolio of epistemic objects guides planning practitioners as they weigh planning decisions, address organizational path dependencies, confront personal, institutional, and systemic biases, and ensure that women’s inequity does not continue to be manifested and embedded in spatial patterns and decisions. Supplementary materials have been provided to augment the findings outlined in this synthesis paper. A complete catalogue of the Canadian gender-based planning instruments found through this research has been compiled into a summary table. The table includes the city and province of each intervention, year, instrument name, instrument type, stage of activity (e.g., planning, engagement, operational, monitoring and evaluation, etc.), Council and operational supports, and participation in the UNESCO Inclusive Municipalities program. The supplementary materials also include an intervention matrix, which summarizes the priority area, categorical objective, aspect targeted (e.g., policy, leadership, accountability, etc.), intersectional characteristics identified, instrument type, target audience, stage of activity, and indicators identified for each women’s equity objective statement found in the research.
Additional file 2 of MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis
Creators: name: Raji, Sara
name: Sahranavard, Mehrdad
name: Mottaghi, Mahdi
name: Sahebkar, Amirhossein
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 2: Table S1, S2 and Figure S1–S43.
Brief von Merfeld an Leopold Zunz, 01.04.1850
Creators: name: (:Unkn) Unknown
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1850
Subjects: subject: 090

description: Bitte des Vorstands der Bielefelder jüdischen Gemeinde um Rat wegen der geplanten jüdische Central-Behörde
Synthese und Charakterisierung von acyclischen Carben-Pt(II)- und Pt(IV)-Komplexen und ihr Effekt auf Caco-2-Zellen
Creators: name: Gawlik, Nicole Stephanie
Publisher: name: Bergische Universität Wuppertal
Year: 2024

description: Ausgehend von vier verschiedenen Isonitrilen RCN (R= 4-Chlorphenyl, 2,6-Dichlorphenyl, 4-Isopropylphenyl oder 2,6-Dimethylphenyl) und Dichlorobis-(dimethylphenylphosphan)-‘-dichlorodiplatin wurden Isonitrilplatinkomplexe synthetisiert, die anschließend als Ausgangsmaterial für acyclische Carbenkomplexe (ACC) dienten. Diese wurden durch die Addition entsprechender Amine und Alkohole generiert. Zusätzlich zur Charakterisierung mittels NMR-Spektroskopie und Röntgenstrukturanalyse wurden sechs N-acyclischen Carbenkomplexe (NAC) auf ihre potenzielle Anwendung als Krebsmedikamente durch die Bestimmung ihrer antiproliferativen Aktivität untersucht. Basierend auf dem positiven Effekt wurden weitere Studien zur Zellviabilität mit den Verbindungen an der Zelllinie Caco-2/TC7 durchgeführt, die in einigen Fällen eine höhere zytotoxische Aktivität als Cisplatin zeigten. Einige NAC-Komplexe wurden außerdem durch die Addition von Chlor oxidiert und diese Pt(IV)-Komplexe ebenfalls charakterisiert. Der Großteil der Pt(IV)-Komplexe lag orthometalliert vor, was sowohl anhand der Molekülstrukturen, aber auch im 31P-NMR-Spektrum erkennbar war.
description: Starting from four different isonitriles RCN (R = 4-chlorophenyl, 2,6-dichlorophenyl, 4-isopropylphenyl or 2,6-dimethylphenyl) and dichlorobis-(dimethylphenylphosphane)-'-dichlorodiplatinum, isonitrile-platinum(II) complexes were synthesised, which subsequently served as starting materials for acyclic carbene complexes (ACC). These were generated by the addition of corresponding amines and alcohols. In addition to characterisation by NMR spectroscopy and X-ray structure analysis, six N-acyclic carbene (NAC) complexes were investigated for their potential application as anticancer drugs by determining their antiproliferative activity. Based on the positive effect, further cell viability studies were performed with the compounds on the Caco-2/TC7 cell line, which in some cases showed higher cytotoxic activity than cisplatin. Some NAC complexes were also oxidised by the addition of chlorine and these Pt(IV) complexes were evenfalls characterised. The majority of the Pt(IV) complexes were ortho-metalated, which was obvious from the molecular structures, but also from the 31P-NMR spectra.
On Practical Subversion-Resilience
Creators: name: Bemmann, Pascal
Publisher: name: Bergische Universität Wuppertal
Year: 2024

description: The 2013 Snowden revelations exposed state-level adversaries' ability to compromise widely used cryptographic schemes via so-called subversion attacks. The scientific community responded by developing models to capture and counter these attacks. However, generic attacks showed the necessity of additional assumptions. One approach is introducing a trusted guardian, the watchdog, to validate cryptographic implementations. This thesis focuses on enhancing practicality in two key domains in the watchdog model while minimizing reliance on trust and avoiding random oracles. Our contributions include the first construction of public-key encryption with practical watchdogs requiring linear testing time, improving feasibility for real-world deployment. Additionally, we introduce the first authenticated encryption and digital signature constructions that are secure under complete subversion without relying on random oracles. While further improvements are needed for large-scale deployment, this thesis represents significant progress toward practical subversion-resilient schemes.
title: Représentations du corps enseignant des cycles 1 et 2 sur l'utilisation de tablettes numériques en 1:1
title: Représentations du corps enseignant des cycles 1 et 2 sur l'utilisation de tablettes numériques en 1:1
titleType: AlternativeTitle
Creators: name: Fernandez, Magali
name: Schmid, Sandy
Publisher: name: Unknown
Year: 0
Subjects: subject: MITIC
subject: tablettes numériques
subject: 1:1
subject: profil d'utilisateur
subject: dispositif
subject: représentations

description: Ce mémoire s’intéresse aux représentations des enseignants-es des cycles 1 et 2 (correspondant aux degrés primaires en Suisse) sur un dispositif d’utilisation des tablettes numériques en 1:1 (un élève – une tablette). Par le biais d’un questionnaire, nous avons demandé aux enseignants-es d’imaginer qu’ils ou elles allaient recevoir une tablette pour chacun de leurs élèves à la rentrée prochaine. Quelle serait leur réaction ? Quels sont leurs sentiments vis-à-vis de ce dispositif ? leurs craintes ? leurs besoins ? Que leur faudrait-il pour qu’ils-elles se sentent prêts-es à accueillir un tel projet ? Nous pensons que dans un futur plus ou moins proche, la mise en place d’un tel dispositif dans les classes primaires suisses pourrait voir le jour et c’est ainsi, dans une optique d’implication pratique, qu’un questionnaire destiné aux enseignants-es des établissements qui veulent implanter ce dispositif a été créé. Il permet de les répartir en trois profils d’utilisateurs-trices nommés « Novice », « Autonome » et « Expert » et qui présentent tous un rapport différent aux MITIC. Notre recherche montre que chacun de ces profils a une représentation du dispositif en 1:1 divergente. Ainsi, pour favoriser cette implantation, une formation et un accompagnement spécifiques à chaque profil pourraient être envisagés pour répondre, au plus près, à leurs besoins.
The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome
Creators: name: Braat, Sien
name: D'Hulst, Charlotte
name: Heulens, Inge
name: Rubeis, Silvia De
name: Mientjes, Edwin
name: Nelson, David L
name: Willemsen, Rob
name: Bagni, Claudia
name: Dam, Debby Van
name: Deyn, Peter P De
name: R Frank Kooy
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Previous research indicates that the GABAAergic system is involved in the pathophysiology of the fragile X syndrome, a frequent form of inherited intellectual disability and associated with autism spectrum disorder. However, the molecular mechanism underlying GABAAergic deficits has remained largely unknown. Here, we demonstrate reduced mRNA expression of GABAA receptor subunits in the cortex and cerebellum of young Fmr1 knockout mice. In addition, we show that the previously reported underexpression of specific subunits of the GABAA receptor can be corrected in YAC transgenic rescue mice, containing the full-length human FMR1 gene in an Fmr1 knockout background. Moreover, we demonstrate that FMRP directly binds several GABAA receptor mRNAs. Finally, positive allosteric modulation of GABAA receptors with the neurosteroid ganaxolone can modulate specific behaviors in Fmr1 knockout mice, emphasizing the therapeutic potential of the receptor.
Πρώιμη ανθρώπινη παρουσία στα νησιά του Αιγαίου: μια κριτική επαναθεώρηση των βιογεωγραφικών προσεγγίσεων
Creators: name: Χούμας, Στέλιος Εμμανουήλ
Publisher: name: Aristotle University of Thessaloniki
Year: 2022
Subjects: Νησιωτική Αρχαιολογία
Αιγαίο
Βιογεωγραφία
Island Archaeology
Aegean
Biogeography

description: Η πρώιμη ανθρώπινη δραστηριότητα στα νησιωτικά περιβάλλοντα έχει απασχολήσει ιδιαίτερα την επιστήμη της Αρχαιολογίας τις τελευταίες δεκαετίες, με μια πληθώρα θεωρητικών προσεγγίσεων να επιχειρούν να ερμηνεύσουν τη μετακίνηση των ανθρώπων στα νησιά. Το Αιγαιακό αρχιπέλαγος αποτελεί μια από τις ευνοϊκότερες περιοχές ανά την υφήλιο για την μελέτη αυτής της θεματικής. Στην παρούσα διπλωματική εργασία εξετάστηκαν τόσο τα δεδομένα της αρχαιολογικής έρευνας από τα νησιά του Αιγαίου που αφορούν τρείς αρχαιολογικές περιόδους: την Παλαιολιθική, τη Μεσολιθική και τη Νεολιθική, όσο και οι θεωρητικές και ερμηνευτικές προσεγγίσεις που έχουν διατυπωθεί με βάση αυτά, εστιάζοντας κυρίως στην επαναθεώρηση των προσεγγίσεων που εμπνέονται από την θεωρία της Νησιωτικής Βιογεωγραφίας. Στην εργασία αναλύονται όροι όπως: η παλαιογεωγραφία, ο αποικισμός, η βιωσιμότητα, η εγκατάλειψη, η απομόνωση και η διάδραση
description: Early human activity in insular environments has been the focus of attention by Archaeological studies of the last decades, with various theoretical approaches attempting to interpret the movement of humans to the islands. The Aegean archipelago constitutes one of the most suitable areas worldwide for the study of this topic. In the present essay the archaeological date of the Aegean islands from three prehistoric periods were examined; the Paleolithic, the Mesolithic and the Neolithic. In addition, theoretical approaches based on the available evidence were presented and discussed, aiming at reviewing hypotheses and ideas inspired by the theory of Island Biogeography. Some of the terms discussed in the study are: paleogeography, colonization, viability, sustainability, abandonment, isolation and interaction
LAPORAN PRAKTIKUM 2 (BOTANI TUMBUHAN TINGGI)
Creators: name: SITI NOR KHALISAH
Publisher: name: Zenodo
Year: 2020

description: Assalamualaikum Ibu atau Kaka Kaka:) Ulun Siti Nor KhalisahKhalisah. Ini laporan praktikum 2 ulun yang daftar pustaka sudah di revisi 🙏
Additional file 1 of Foot-related diabetes complications: care pathways, patient profiles and costs
Creators: name: Kurkela, Olli
name: Nevalainen, Jaakko
name: Arffman, Martti
name: Lahtela, Jorma
name: Forma, Leena
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Flow chart for defining the study population. Number of people excluded in each step is indicated by a dashed box.
Additional file 2 of Foot-related diabetes complications: care pathways, patient profiles and costs
Creators: name: Kurkela, Olli
name: Nevalainen, Jaakko
name: Arffman, Martti
name: Lahtela, Jorma
name: Forma, Leena
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Most typical care pathways in each group of pathways. Within groups, pathways are stratified according to type and number of care episodes.
Allelic variation observed at one microsatellite locus between the two synonym grape cultivars Black Currant and Mavri Corinthiaki
Creators: name: Ibanez, J.
name: De Andres, M. T.
name: Borrego, J.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: Research Note Black Currant and Mavri Corinthiaki are considered synonyms for Corinthe Noir, a parthenocarpic seedless raisin cultivar. No differences between them were found by RAPD analysis with 1 1 primers. They also have the same genotype in 15 out of 16 microsatellite loci, demonstrating the Black Currant and Mavri Corinthiaki are essentially identical. Nevertheless, a difference was observed in one allele at one locus (VVMD7): the Black Currant genotype is 240:246 while the Mavri Corinthiaki genotype is 240:248. A mutation in the microsatellite sequence might be responsible for that difference. Possible consequences of such mutations are discussed.
description: VITIS - Journal of Grapevine Research, Vol. 39 No. 4 (2000): Vitis
Additional file 3 of Foot-related diabetes complications: care pathways, patient profiles and costs
Creators: name: Kurkela, Olli
name: Nevalainen, Jaakko
name: Arffman, Martti
name: Lahtela, Jorma
name: Forma, Leena
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Costs of care pathways in the study population and by group (all costs in year 2017 euros).