cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Antimicrobial substances from Amazonian Aniba (Lauraceae) species
Creators: name: da Silva, Yasmin Cunha
name: Silva, Emily Marcele Soares
name: de Souza Fernandes, Nilma
name: Lopes, Nathália Lamenha
name: Orlandi, Patrícia Puccinelli
name: Vataru Nakamura, Celso
name: Vilaça Costa, Emmanoel
name: da Veiga Júnior, Valdir Florêncio
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Biology

description: Extracts and six isolated substances from Aniba (Lauraceae) Amazonian species A. parviflora, A. panurensis and A. rosaeodora were analysed in vitro to their antibacterial, antiparasitic and antiplasmodial activities. NMR and MS experiments led to the identification of three styrylpyrones (5,6-dihydrokawain [I], 4-methoxy-11,12-methylenedioxy-6-trans-styryl-pyran-2-one [II] and rel-(6R,7S,8S,5′S)-4′-methoxy-8-(11,12-dimethoxyphenyl-7-[6-(4-methoxy-2-pyranyl)]-6-(E)-styryl-1′-oxabicyclo[4,2,0]oct-4′-en-2′-one [III]), a pyridine alkaloid (anibine [IV]) and two kavalactones (tetrahydroyangonin [V] and dihydromethysticin [VI]). The best antibacterial result was observed at the hexane fraction of A. panurensis (MIC 7.8 μg/mL against the three bacteria). Equal MIC were observed by the extract and dichloromethane fraction of A. panurensis against S. simulans and S. aureus; and 15.62 μg/mL against MRSA. Similarly, only A. panurensis extracts showed in vitro activities against Tripanossoma cruzi and Leishmania amazonensis parasites. In Plasmodium falciparum assay, 5,6-dihydrokawain was considered an active antimalarial (14.03 μM), and substances II (132.94 μM) and III (41.84 μM) presented moderate activities.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00102
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00102, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Cryptotanshinone and tanshinone IIA from Salvia milthorrhiza Bunge (Danshen) as a new class of potential pancreatic lipase inhibitors
Creators: name: Marrelli, Mariangela
name: Grande, Fedora
name: Occhiuzzi, Maria Antonietta
name: Maione, Francesco
name: Mascolo, Nicola
name: Conforti, Filomena
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Salvia miltiorrhiza Bunge extract was investigated for the first time for its inhibitory activity against pancreatic lipase (PL), an important enzyme involved in the digestion of dietary fats. It showed a concentration-dependent activity with an IC50 value of 3.54 ± 0.22 mg/mL. Two compounds, cryptotanshinone and tanshinone IIA (the major lipophilic constituents of S. miltiorrhiza), have been selected as potential ligands of PL. Cryptotanshinone showed a higher lipase inhibitory activity (IC50 = 6.86 ± 0.43 µM) compared to the parent tanshinone IIA. Molecular docking studies were undertaken to establish whether a direct interaction of the principal constituents of the S. miltiorrhiza extract with the human pancreatic lipase could be evoked. All these findings provided new insights into the understanding of the interactions between natural constituents of S. miltiorrhiza extract and PL, also suggesting that cryptotanshinone could be used as lead compound for the development of efficacious PL inhibitors.
Supplementary FIGURE 1 from Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation
Creators: name: Huguet, Florentin
name: Gokham, Ezgi
name: Foster, Helen A.
name: Amin, Hasnat A.
name: Vagnarelli, Paola
Publisher: name: The Royal Society
Year: 2022
Subjects: Biochemistry
Cell Biology

description: A) Representative images of HeLa cells stained for lamin A S22ph (red) and DAPI. A metaphase (top panel), an ana/telophase (middle panel) and a cytokinesis (bottom panel) are shown. Scale bar 10 µm. B) Representative images of the experiment quantified in Figure 3 E. HeLa cells were treated with RepoMan siRNA oligos, transfected with either the oligo-resistant versions of GFP:RepoManwt or GFP:RepoManIRCE mutant (green) for 36h then fixed and stained for anti lamin A S22ph (red). C) Representative of the experiment quantified in Figure 3 G. PLA conducted in HeLa cells transfected with either GFP:RepoManwt or GFP:RepoManIRCE mutant. The primary antibodies were anti GFP and anti laminAS22.
Gap-planar Graphs
Creators: name: Bae, Sang Won
name: Baffier, Jean-Francois
name: Chun, Jinhee
name: Eades, Peter
name: Eickmeyer, Kord
name: Grilli, Luca
name: Hong, Seok-Hee
name: Korman, Matias
name: Montecchiani, Fabrizio
name: Rutter, Ignaz
name: Tóth, Csaba D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computational Geometry (cs.CG)
subject: FOS: Computer and information sciences

description: We introduce the family of $k$-gap-planar graphs for $k \geq 0$, i.e., graphs that have a drawing in which each crossing is assigned to one of the two involved edges and each edge is assigned at most $k$ of its crossings. This definition is motivated by applications in edge casing, as a $k$-gap-planar graph can be drawn crossing-free after introducing at most $k$ local gaps per edge. We present results on the maximum density of $k$-gap-planar graphs, their relationship to other classes of beyond-planar graphs, characterization of $k$-gap-planar complete graphs, and the computational complexity of recognizing $k$-gap-planar graphs.
description: A preliminary version of this paper appeared in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017)
Essential oil from Artemisia annua aerial parts: composition and repellent activity against two storage pests
Creators: name: Liu, Hong
name: Guo, Shan-Shan
name: Lu, Li
name: Li, Dian
name: Liang, Jun
name: Huang, Zhong-Hui
name: Zhou, Yan-Mei
name: Zhang, Wen-Juan
name: Du, Shushan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: As a medicinal plant, Artemisia annua is widely distributed in China. The purpose of this work was to analyze the chemical composition of essential oil from A. annua aerial portions, as well as to assess its repellent activity against Lasioderma serricorne and Tribolium castaneum adults. GC-FID and GC-MS analyses enabled the identification of 15 components representing 90.1% of the essential oil. The main components included artemisia ketone (70.6%), α-caryophyllene (5.1%) and germacrene D (3.8%). The essential oil was found to possess considerable ability to repel the two storage pests. This paper provided some evidence for the exploitation and utilization of A. annua resources as a natural repellent.
title: La surcharge pastorale en pays Zaer
title: La surcharge pastorale en pays Zaer
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Pastoralisme

description: Cartographie
description: BESM-carto_1960-86-87-p251_86-87-03
description: 87
description: 86
description: Bulletin économique et social du Maroc
description: Source: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Source: Bulletin économique et social du Maroc
description: Source: Bulletin économique et social du Maroc (BESM) > BESM (Cartographie)
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/81929
description: Coverage: Maroc
description: Coverage: Zaër
description: Coverage: XXe siècle
description: Temporal: XXe siècle
description: Bibliographic citation: « La surcharge pastorale en pays Zaer », In Bulletin économique et social du Maroc (BESM), n° 86, 1960
description: Provenance: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Provenance: https://cinumed.mmsh.univ-aix.fr/
de Sitter symmetries and inflationary correlators in parity violating scalar-vector models
Creators: name: Almeida, Juan P. Beltrán
name: Motoa-Manzano, Josué
name: Valenzuela-Toledo, César A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we use conformal field theory techniques to constrain the form of the correlations functions of an inflationary scalar-vector model described by the interaction term $f_1(ϕ)F_{μν}F^{μν} + f_2(ϕ)\tilde{F}_{μν}F^{μν}$. We use the fact that the conformal group is the relevant symmetry group acting on super horizon scales in an inflationary de Sitter background. As a result, we find that super horizon conformal symmetry, constraints the form of the coupling functions $f_1, f_2$ to be homogeneous functions of the same degree. We derive the general form of the correlators involving scalar and vector perturbations in this model and determine its squeezed limit scaling behaviour for super horizon scales. The approach followed here is useful to constraint the shape of scalar-vector correlators, and our results agree with recent literature on the subject, but don't allow us to determine amplitude factors of the correlators.
description: References added. Discussion about invariance under special conformal transformations improved. Matches published version
A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2
Creators: name: Wang, Shixia
name: Wang, Chang Yi
name: Kuo, Hui-Kai
name: Peng, Wen-Jiun
name: Huang, Juin-Hua
name: Kuo, Be-Shen
name: Lin, Feng
name: Liu, Yaw-Jen
name: Liu, Zhi
name: Wu, Huang-Ting
name: Ding, Shuang
name: Hou, Kou-Liang
name: Cheng, Jennifer
name: Yang, Ya-Ting
name: Jiang, Ming-Han
name: Wang, Min-Sheng
name: Chen, Tony
name: Xia, Wei Guo
name: Lin, Ed
name: Hung, Chung Ho
name: Chen, Hui-Jung
name: Shih, Zhonghao
name: Lin, Yi Ling
name: Ryan, Valorie
name: Hu, Mei Mei
name: Heppner, D. Gray
name: Malherbe, Delphine C.
name: Periasamy, Sivakumar
name: Kuzmina, Natalia
name: Subramani, Chandru
name: Hellerstein, Michael
name: Monath, Thomas P.
name: Rumyantsev, Alexander
name: Bukreyev, Alexander
name: Guirakhoo, Farshad
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike protein fused to a modified single-chain human IgG1 Fc; (ii) five synthetic peptides incorporating conserved helper and cytotoxic T lymphocyte (Th/CTL) epitopes derived from SARS-CoV-2 structural proteins (three from S2 subunit, one from membrane and one from nucleocapsid), and one universal Th peptide; (iii) aluminum phosphate as adjuvant. The immunogenicity and protective immunity induced by UB-612 vaccine were evaluated in four animal models: Sprague–Dawley rats, AAV-hACE2 transduced BALB/c mice, rhesus and cynomolgus macaques. UB-612 vaccine induced high levels of neutralizing antibody and T-cell responses, in all animals. The immune sera from vaccinated animals neutralized the SARS-CoV-2 original wild-type strains and multiple variants of concern, including Delta and Omicron. The vaccination significantly reduced viral loads, lung pathology scores, and disease progression after intranasal and intratracheal challenge with SARS-CoV-2 in mice, rhesus and cynomolgus macaques. UB-612 has been tested in primary regimens in Phase 1 and Phase 2 clinical studies and is currently being evaluated in a global pivotal Phase 3 clinical study as a single dose heterologous booster.
Supplementary FIGURE 3 from Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation
Creators: name: Huguet, Florentin
name: Gokham, Ezgi
name: Foster, Helen A.
name: Amin, Hasnat A.
name: Vagnarelli, Paola
Publisher: name: The Royal Society
Year: 2022
Subjects: Biochemistry
Cell Biology

description: A) GFP pull-down on HeLa cells transfected with either GFP:RepoMan wt or GFP:RepoMan IRCE or GFP:Repo-Man S893D. The samples were run on SDS PAGE, blotted and probed with either GFP antibody (bottom panels) of anti SUMO2/3 antibody (top panels). B=bound fraction. B) Representative images of HeLa cells transfected with either GFP:RepoMan wt (top panel), GFP:RepoMan S893D (middle panel) or GFP lamin A (bottom panel) (green). In yellow is the line scan in ImageJ used to quantify the distribution of the green signal. The profiles are represented in the graph on the right of each panel. The red arrows represent the increase in signal on the chromatin for Repo-Man wt and the decrease in signal on the chromatin for lamin A. However, the GFP:RepoMan S893D mutant is not showing exclusion form the chromatin but rather lack of accumulation.
Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae)
Creators: name: Salmazzo, Gustavo Ruivo
name: Verdan, Maria Helena
name: Silva, Flávia
name: Cicarelli, Regina Maria
name: da Silva Mota, Jonas
name: Salvador, Marcos José
name: de Carvalho, João Ernesto
name: Cardoso, Cláudia Andrea Lima
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Chemical investigation of the extracts of the fruits from Campomanesia xanthocarpa resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2′,4′-dihydroxy-5′-methyl-6′-methoxychalcone (1), 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (2), 2′-hydroxy-3′-methyl-4′,6′-dimethoxychalcone (3), 2′,6′-dihydroxy-3′-methyl-4′-methoxychalcone (4), 5-hydroxy-7-methoxy-8-methylflavanone (5) and 7-hydroxy-5-methoxy-6-methylflavanone (6)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and 5 was done in vitro, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC50 values ranging from 4.75 to 45.81 µmol L−1. The in vitro trypanocidal activity was evaluated against the epimastigote form of the Y strain of Trypanosoma cruzi and an improvement in the activity of the substances 2 (221.81 µmol L−1) and 5 (61.87 µmol L−1) was observed regarding the values obtained for the extracts.
NEW METHODS OF CLUSTERING THE PROSODIC VARIATION OF ITALO-ROMANCE DIALECTS
Creators: name: De Iacovo, Valentina
Publisher: name: RiCOGNIZIONI. Rivista di Lingue e Letterature straniere e Culture moderne
Year: 2018

description: As suggested by several authors (among those, Contini 1991), prosodic variation may be analysed in a dialectometrical perspective, leading to the construction of geoprosodic maps. Language atlases are in facts conceived as empirical database allowing a detailed documentation of specific language features by the collection of a consistent number of locations. At a later time, data are treated and classified according to different methodologies in order ‘to abstract and visualise a basic pattern from the immense amount of data found in the language atlases’ (Nerbonne & Kretzschmar, 2013). This kind of approach can be adopted for the investigation of the prosodic variation, allowing the clusterisation of different dialectal varieties. For this study, 8 Italian dialectal varieties have been considered: the data processing consisted in mesuring the prosodic distance (Hermes 1998, Romano 2001) existing among the varieties, expressed by a correlation matrix. Values have later been grouped according to several hierarchical clustering techniques such as heat maps, dendrograms and phylogenic trees, in order to illustrate how dialectal varieties can be grouped according to peculiar prosodic variations, fostering the prosodic analysis towards a geoprosodic perspective.
description: RiCOGNIZIONI. Rivista di Lingue e Letterature straniere e Culture moderne, V. 5 N. 9 (2018)
Lettre de Jean-François Séguier à Michele Enrico Sagramoso, 1754-04-16
Creators: name: Séguier, Jean-François
name: Jean-François Séguier
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Librairie

description: [transcription] Monsieur,

Je cherche actuellement un livre que je voudrais procurer à un de mes amis Allemand, à qui j'ai mille obligations. Vous pouvez mieux que tout autre m'aider pour le découvrir et me le faire avoir par votre crédit. Voici de quoi il s'agit. Feu Monsieur le Cardinal Barbarigo, personnage qui était doué des plus rares qualités et qui surtout était extrêmement magnifique et libéral, fit imprimer un grand in folio à ses dépens, qui contenait toutes les empreintes des médaillés battues à l'honneur des Illustres de sa famille, et le titre en est Numimsmata Gentil Barbaricae. Il y aura quantité de personne et de nobles Vénitiens de cette famille à qui Son Eminence aura fait présent de cet ouvrage. S'il était possible d'engager quelques-uns de ceux qui le possèdent de s'en défaire à un prix raissonnable, vous me fériez plaisir de me ménager cette ouverture et ce contrat. Messere Barbarigo, qui a des sentiments aussi élevés et aussi nobles que le feu cardinal, voudra bien s'y intéresser à votre recommandation, surtout lorsqu'elle saura que c'est pour un illustre savant qui ramasse tous les ouvrages de cette espece, non pas tant pour enrichir son cabinet, que pour se mettre a portée de publier les vertus et les éloges des familles aussi illustres. Je vous prie donc, Monsieur, de vous donner quelque soin pour m'obtenir un exemplaire de ce livre, que j'ai en vain cherché jusqu'ici : vos connaissances et votre crédit peuvent seuls me le faire obtenir, et me mettre en état de rendre à un ami une bien petite reconnaissance pour tant de bontés dont je lui suis redevable.

J'ai l'honneur d'être avec un attachement respectueux et sincère,

Monsieur,

Votre très humble et très obéissant Serviteur

Séguier

A Vérone le 16 avril 1754

A Monsieur

Monsieur le Marquis Sagramoso

Chevalier de Malte

in Calle Larga S. Marco

Venezia

[Séguier

a Venezia 1754]
description: [note autre main] [Séguier

a Venezia 1754]
description: [personnes citées] Alvise Barbarigo, Giovanni Francesco Barbarigo
description: [reférence bibliographique citée] Numismata virorum illustrium ex Barbadica gente, Pavie, 1732.
description: [lettre editée aussi sur] Eros Maria Luzzitelli, Ippolito Pindemonte e la fratellanza con Aurelio De'Giorgi Bertola tra Scipione Maffei e Michele Enrico Sagramoso : una nuova questione sulle origini della massoneria in Italia, con appendice di carteggi e documenti inediti, Vérone, Libreria universitaria, 1987, p. 192
description: Source: [lieu de Conservation] Vérone, Biblioteca Capitolare [cote]non précisée
Effects of NMDA antagonists on social behavior: a systematic review and meta-analysis of preclinical studies
Creators: name: Müller, Daniela Varisco
name: Bastos, Leonardo Marensi
name: Abreu, Mariana
name: Gallas-Lopes, Matheus
name: Andrades, Michael
name: Stein, Dirson João
name: Herrmann, Ana P.
name: Tainah Couto Caetano
name: Rosa, Daniel Alves
name: Arbo, Bruno Dutra
name: De Castro Santos, Aline
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medical Sciences
subject: Medicine and Health Sciences
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Social and Behavioral Sciences
subject: Animal Studies

description: Pre-registered search terms for a systematic review of the effects of NMDA antagonists on the social behavior of laboratory animals.
A Novel RBD-Protein/Peptide Vaccine Elicits Broadly Neutralizing Antibodies and Protects Mice and Macaques against SARS-CoV-2
Creators: name: Wang, Shixia
name: Wang, Chang Yi
name: Kuo, Hui-Kai
name: Peng, Wen-Jiun
name: Huang, Juin-Hua
name: Kuo, Be-Shen
name: Lin, Feng
name: Liu, Yaw-Jen
name: Liu, Zhi
name: Wu, Huang-Ting
name: Ding, Shuang
name: Hou, Kou-Liang
name: Cheng, Jennifer
name: Yang, Ya-Ting
name: Jiang, Ming-Han
name: Wang, Min-Sheng
name: Chen, Tony
name: Xia, Wei Guo
name: Lin, Ed
name: Hung, Chung Ho
name: Chen, Hui-Jung
name: Shih, Zhonghao
name: Lin, Yi Ling
name: Ryan, Valorie
name: Hu, Mei Mei
name: Heppner, D. Gray
name: Malherbe, Delphine C.
name: Periasamy, Sivakumar
name: Kuzmina, Natalia
name: Subramani, Chandru
name: Hellerstein, Michael
name: Monath, Thomas P.
name: Rumyantsev, Alexander
name: Bukreyev, Alexander
name: Guirakhoo, Farshad
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike protein fused to a modified single-chain human IgG1 Fc; (ii) five synthetic peptides incorporating conserved helper and cytotoxic T lymphocyte (Th/CTL) epitopes derived from SARS-CoV-2 structural proteins (three from S2 subunit, one from membrane and one from nucleocapsid), and one universal Th peptide; (iii) aluminum phosphate as adjuvant. The immunogenicity and protective immunity induced by UB-612 vaccine were evaluated in four animal models: Sprague-Dawley rats, AAV-hACE2 transduced BALB/c mice, rhesus and cynomolgus macaques. UB-612 vaccine induced high levels of neutralizing antibody and T-cell responses, in all animals. The immune sera from vaccinated animals neutralized the SARS-CoV-2 original wild-type strains and multiple variants of concern, including Delta and Omicron. The vaccination significantly reduced viral loads, lung pathology scores, and disease progression after intranasal and intratracheal challenge with SARS-CoV-2 in mice, rhesus and cynomolgus macaques. UB-612 has been tested in primary regimens in Phase 1 and Phase 2 clinical studies and is currently being evaluated in a global pivotal Phase 3 clinical study as a single dose heterologous booster. Trial registration:ClinicalTrials.gov identifier: NCT05293665..
Spin-polarized Andreev tunneling through the Rashba chain
Creators: name: Maska, M. M.
name: Domanski, T.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We demonstrate that the selective equal spin Andreev reflection (SESAR) spectroscopy can be used in STM experiments to distinguish the zero-energy Majorana quasiparticles from the ordinary fermionic states of the Rashba chain. Such technique, designed for probing the p-wave superconductivity, could be applied to the intersite pairing of equal-spin electrons in the chain of magnetic Fe atoms deposited on the superconducting Pb substrate. Our calculations of the effective pairing amplitude for individual spin components imply the magnetically polarized Andreev conductance, which can be used to `filter' the Majorana quasiparticles from the ordinary in-gap states, although the pure spin current (i.e., perfect polarization) is impossible.
description: 8 pages, 6 figures
title: Live Cell Lineage Tracing of Dormant Cancer Cells
Creators: name: Kim, Hyuna
name: Wirasaputra, Anna
name: Mohammadi, Farnas
name: Kundu, Aritra Nath
name: Esteves, Jennifer
name: Heiser, Laura
name: Meyer, Aaron
name: Peyton, Shelly
Publisher: name: University of Massachusetts Amherst
Year: 2023
Subjects: subject: Breast cancer
subject: biomaterials
subject: collagen
subject: Matrigel
subject: poly(ethylene glycol) hydrogel

description: Breast cancer is a leading cause of global cancer-related deaths, and metastasis is the overwhelming culprit of poor patient prognosis. The most nefarious aspect of metastasis is dormancy, a prolonged period between primary tumor resection and relapse. Current therapies are insufficient at killing dormant cells; thus, they can remain quiescent in the body for decades until eventually undergoing a phenotypic switch, resulting in metastases that are more adaptable and more drug resistant. Unfortunately, dormancy has few in vitro models, largely because lab-derived cell lines are highly proliferative. Existing models address tumor dormancy, not cellular dormancy, because tracking individual cells is technically challenging. To combat this problem, we adapted a live cell lineage approach to find and track individual dormant cells, distinguishing them from proliferative and dying cells over multiple days. We applied this approach across a range of different in vitro microenvironments. Our approach revealed that the proportion of cells that exhibited long-term quiescence was regulated by both cell intrinsic and extrinsic factors, with the most dormant cells found in 3D collagen gels. We envision that this approach will prove useful to biologists and bioengineers in the dormancy community to identify, quantify, and study dormant tumor cells.
Supplementary FIGURE 2 from Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation
Creators: name: Huguet, Florentin
name: Gokham, Ezgi
name: Foster, Helen A.
name: Amin, Hasnat A.
name: Vagnarelli, Paola
Publisher: name: The Royal Society
Year: 2022
Subjects: Biochemistry
Cell Biology

description: A) Sequence alignment between Repo-Man wt and the IRCE mutant generated. B) GFP pull-down on HeLa cells transfected with either GFP or GFP:RepoMan wt or GFP:RepoMan IRCE. The samples were run on SDS PAGE, blotted and probed with either GFP antibody (left panel) or anti SUMPO2/3 antibody (right panel). UB=unbound fraction B=bound fraction. C) HeLa cells were transfected with either GFP or GFP:RepoManwt. The GFP constructs were pulled-down with GFP-binder beads and incubated with recombinant purified lamin A. Western blot of the unbound (UB) and bound (B) fractions probed with anti GFP (Bottom panel), lamin A (middle panel) and RepoMan (top panel) antibodies. D) Quantification of the mitotic progression (1–3 h from release) of the HCT116 RepoMan:FKBP:GFP (green) / pMito-mCherry-FRB (red) cell line with and without rapamycin from the experiment designed in Figure 3 D. between 75–100 cells were analysed per each condition. The datasets with and without rapamycin at each time point were statistically analysed with a Chi Square test. Ns= not significant.
Phytochemical analysis and evaluation of antioxidant and antimycobacterial activity of Colletia paradoxa from Brazil
Creators: name: Záchia, Nelci Rolim Bastos
name: Piana, Mariana
name: dos Santos Siqueira, Fallon
name: da Silva Jesus, Roberta
name: Athayde, Margareth Linde
name: Essi, Liliana
name: de Campos, Marli Matiko Anraku
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Plant Biology

description: Colletia paradoxa (Spreng.) Esc. (Rhamnaceae, Colletieae) is a medicinal plant, threatened with extinction in Brazil, presenting great morphological variability. Our objective is to investigate the phytochemical components, antioxidant capacity and antimycobacterial activity of different morphotypes of C. paradoxa in different environments. For this, the crude extract of the leaves and branches of the individuals sampled was used. The elimination capacity of the free radicals was determined by the DPPH method, the antimycobacterial activity by the broth microdilution method and the phenolic content by the spectrophotometric method using the Folin-Ciocalteu reagent and by HPLC. The extracts of C. paradoxa and its morphotypes showed significant amounts of phenolic compounds, including quercetin, quercitrin and rutin, besides considerable antioxidant and antimycobacterial activity No connection was detected between the phytochemical composition and different morphotypes of C. paradoxa.
BIOPOLITICS AND THE BODY IN NAZI CINEMA
Creators: name: Baroni, Raissa
Publisher: name: RiCOGNIZIONI. Rivista di Lingue e Letterature straniere e Culture moderne
Year: 2018

description: From the logocentric culture to the visual culture, the cinema has gained its emancipation as most powerful and important of arts, especially due to the totalitarian strategies that used it toward an aestheticization of politics to control the masses. The following is an analysis of the effects of the totalitarian Nazi power on the body, conducted by means of the German film Triumph of the will by Leni Riefenstahl. On the one hand, through the concept of microphysics of power and the implications of the techniques of the body will be explained how the bio-power works and circulates; on the other hand, this study shows how the viewing of a film can activate the mirror-neurons in our brain and implicate the mimetic desire and the social mimetism.
description: RiCOGNIZIONI. Rivista di Lingue e Letterature straniere e Culture moderne, V. 5 N. 9 (2018)
title: Paratexte (4)_Physiologie du goût
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Paratexte
description: ID_PARA_00654
Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae)
Creators: name: Salmazzo, Gustavo Ruivo
name: Verdan, Maria Helena
name: Silva, Flávia
name: Cicarelli, Regina Maria
name: da Silva Mota, Jonas
name: José Salvador, Marcos
name: Ernesto de Carvalho, João
name: Cardoso, Cláudia Andrea Lima
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Chemical investigation of the extracts of the fruits from Campomanesia xanthocarpa resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2′,4′-dihydroxy-5′-methyl-6′-methoxychalcone (1), 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (2), 2′-hydroxy-3′-methyl-4′,6′-dimethoxychalcone (3), 2′,6′-dihydroxy-3′-methyl-4′-methoxychalcone (4), 5-hydroxy-7-methoxy-8-methylflavanone (5) and 7-hydroxy-5-methoxy-6-methylflavanone (6)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and 5 was done in vitro, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC50 values ranging from 4.75 to 45.81 µmol L−1. The in vitro trypanocidal activity was evaluated against the epimastigote form of the Y strain of Trypanosoma cruzi and an improvement in the activity of the substances 2 (221.81 µmol L−1) and 5 (61.87 µmol L−1) was observed regarding the values obtained for the extracts.
Composition and biological activities of the essential oil from a Sicilian accession of Prangos ferulacea (L.) Lindl
Creators: name: Bruno, Maurizio
name: Ilardi, Vincenzo
name: Lupidi, Giulio
name: Quassinti, Luana
name: Bramucci, Massimo
name: Fiorini, Dennis
name: Venditti, Alessandro
name: Maggi, Filippo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Prangos ferulacea (L.) Lindl. (Fam. Apiaceae), is an orophilous species of eastern Mediterranean and western Asia which possesses several biological properties, which are worthy of exploitation in different fields. With the aim to provide new insights into the phytochemistry and pharmacology of this species, a local accession growing in Sicily (South Italy) was investigated as well. Notably, the P. ferulacea essential oil chemical composition and the antioxidant, anti-acetylcholinesterase (AChE) and cytotoxic activities have been studied. This analysis allowed to identify a new chemotype and to report good biological results for this oil.
Phytochemical analysis and evaluation of antioxidant and antimycobacterial activity of Colletia paradoxa from Brazil
Creators: name: Záchia, Nelci Rolim Bastos
name: Piana, Mariana
name: Siqueira, Fallon dos Santos
name: da Silva Jesus, Roberta
name: Athayde, Margareth Linde
name: Essi, Liliana
name: de Campos, Marli Matiko Anraku
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Plant Biology

description: Colletia paradoxa (Spreng.) Esc. (Rhamnaceae, Colletieae) is a medicinal plant, threatened with extinction in Brazil, presenting great morphological variability. Our objective is to investigate the phytochemical components, antioxidant capacity and antimycobacterial activity of different morphotypes of C. paradoxa in different environments. For this, the crude extract of the leaves and branches of the individuals sampled was used. The elimination capacity of the free radicals was determined by the DPPH method, the antimycobacterial activity by the broth microdilution method and the phenolic content by the spectrophotometric method using the Folin-Ciocalteu reagent and by HPLC. The extracts of C. paradoxa and its morphotypes showed significant amounts of phenolic compounds, including quercetin, quercitrin and rutin, besides considerable antioxidant and antimycobacterial activity No connection was detected between the phytochemical composition and different morphotypes of C. paradoxa.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0651
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0651, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0651, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q15945019
description: Provenance: abbaye Saint-Étienne de Dijon
Investigation of the mechanical properties of polyimide fiber/polyamide 12 composites printed by Multi Jet Fusion
Creators: name: Chen, Mei
name: Hou, Yanbei
name: An, Ran
name: Tey, Wei Shian
name: Gao, Ming
name: Chen, Jiayao
name: Zhao, Lihua
name: Zhou, Kun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Multi Jet Fusion (MJF) has attracted extensive attention because of its ability to print support-free complex structures. However, the mechanical properties of MJF-printed polymer parts are still unsatisfactory for certain industrial requirements. Herein, by leveraging the fibre reinforcement effect and high specific strength of polyimide (PI) fibres, this work developed PI/polyamide 12 (PA12) composites with largely enhanced mechanical performance via MJF. Specifically, the tensile strength and modulus were increased by 43% and 42%, and the flexural strength and modulus were improved by 39% and 46%, respectively, compared to those of the neat PA12 parts. Furthermore, the incorporation of lightweight PI fibres endowed the composites with high specific tensile strength (67.60 kN·m/kg) and specific flexural strength (93.70 kN·m/kg), which are superior to those of MJF-printed PA12 composites reinforced with other fibres. This work provides new insights into enhancing the mechanical performance of lightweight parts printed by MJF and other powder-based techniques.
New 3,4-seco-diterpene and coumarin derivative from the leaves of Trigonostemon flavidus Gagnep
Creators: name: Ban, Ninh Khac
name: Linh, Tran My
name: Chi, Nguyen
name: Tai, Bui Huu
name: Nhiem, Nguyen Xuan
name: Hoang, Nguyen Huy
name: Van Kiem, Phan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Two new compounds named trigoflavidus A (1) and trigoflavidus B (2), and eight known compounds, trigoflavidone (3), heterophypene (4), howpene C (5), 3,4-seco-sonderianol (6), trigonochinene C (7), fraxidin (8), isofraxidin (9), and isofraxetin (10) were isolated from the leaves of Trigonostemon flavidus Gagnep. by various chromatographic methods. Their chemical structures were elucidated via UV, IR, HR-ESI-MS and NMR spectroscopic methods and divided into two groups including six 3,4-seco-diterpenes (1, 3-7) and four coumarins (2, 8-10). Absolute configurations at stereocenters of compound 1 were confirmed by comparison of its CD spectra with those of the TD-DFT calculations. At a concentration of 30 µM, compounds 1–10 exhibited weak cytotoxic activity toward LU1, HepG2, MCF7, and SKMel2 human cell lines (cell viability all over 50%).
Lettre de Jean-André de Luc à Jean-François Séguier, 1772-04-30
Creators: name: Luc, Jean-André de
name: Jean-André De Luc
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Librairie

description: [transcription] Monsieur

Je prends la liberté de vous adresser, sous couvert de Mess.Jacques Gervais et Ciedes programmes d'un ouvrage de physique que je viens de faire imprimer, et que je propose par souscription. c'est celui dont je crois avoir eu l'honneur de vous parler, et auquel je travaillais depuis bien des années.

Je vous prie, Monsieur, de vouloir bien faire circuler ces programmes parmi les amateurs de la physique dans votre ville. J'espère que Mons.Meinier voudra bien vous aider à cette distribution, et je vous serais obligé, en lui proposant, de lui présenter mes très humbles obéissances.
Vous verrez, Monsieur, que ceux qui auront dessein de souscrire, sont adressés chez Mess.Jacques Gervais et Comp. Ainsi j'espère que la grâce que je vous demande, ne vous donnera pas trop d'embarras. Votre ouvrage, Monsieur, sur les fossiles du Véronois, avance t-il? Je sais par expérience combien ces sortes d'ouvrages s'étendent sous la plume [fol. 130v] lorsqu'on veut être exact; surtout quand on a plusieurs objets à la fois. J'avais mon commerce et j'ai eu pendant plusieurs années des soucis de patriote. Vous, Monsieur, outre vos affaires, vous avez le goût des antiquités des hommes, indépendamment de celui des antiquités de la nature; ainsi je conçois comment la production de votre ouvrage s'est éloignée. Je vous souhaite, Monsieur, toute la santé nécessaire pour faire ce présent à l'histoire naturelle, & pour jouir longtemps du bonheur attaché à la satisfaction de ses goûts.
J'ai l'honneur d'être avec une respectueuse considération

Monsieur

Votre très humble et très obéissant serviteur.

Jean André De Luc

Genève le 30 avril 1772

Je n'ai jamais eu de nouvelles de votre correspondant de Vérone à qui vous aviez eu, Monsieur, la bonté d'écrire en faveur de mon cabinet.

[fol. 131v]

Monsieur Séguier célèbre antiquaire et membre de plusieurs académies

A Nîmes
description: [personnes citées] Ménier, Jacques et Cie Gervais
description: [reférence bibliographique citée]
Deluc, Jean-André, Recherches sur les modifications de l’atmosphère, Genève, 1772.
description: Source: [lieu de Conservation] Paris, Bibliothèque nationale de France [cote]NAF 6568, fol. 130-131
description: Source: ark:/12148/btv1b10509441r
[rec. di] Alberto BARACCO, "Hermeneutics of the Film World. A Ricœurian Method for Film Interpretation", Cham, Palgrave Macmillan, 2017 – Cinema e comprensione. Il metodo interpretativo come strategia plastica
Creators: name: Simonigh, Chiara
Publisher: name: RiCOGNIZIONI
Year: 2018

description: Recensione di Alberto BARACCO, Hermeneutics of the Film World. A Ricœurian Method for Film Interpretation, Palgrave Macmillan, 2017
description: RiCOGNIZIONI, V. 4 N. 8 (2017)
New triazole-bearing gramine derivatives – synthesis, structural analysis and protective effect against oxidative haemolysis
Creators: name: Kozanecka-Okupnik, W.
name: Sierakowska, A.
name: Berdzik, N.
name: Kowalczyk, I.
name: Mrówczyńska, L.
name: Jasiewicz, B.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The new series of triazole-bearing gramine derivatives were synthesized through a CuAAC procedure. The structures of all newly obtained compounds were confirmed by spectroscopic analysis and DFT methods. The obtained derivatives were screened for their protective potency against oxidative haemolysis induced by free radicals generated from 2,2’-azobis(2-methylpropionamidine) dihydrochloride (AAPH). Our work demonstrates that derivatives with propyl or octyl linker and phthalimide group associated with indole-triazole moiety, which have a folded structure, effectively protect human erythrocytes against oxidative stress-induced haemolysis.
INTRODUZIONE
Creators: name: Orletti, Franca
Publisher: name: RiCOGNIZIONI
Year: 2018

description: Un rapporto proficuo fra Conversation Analysis (CA) e linguistica applicata, seppur auspicato, può avvenire in maniera non problematica solo per alcuni settori della linguistica applicata - come l’analisi dell’interazione in classe - mentre laddove si ha a che fare con la Second Language Acquisition la strada è decisamente in salita. Chi effettua ricerca nell’ambito della SLA deve integrare la conoscenza dell’apparato categoriale della CA con la continua analisi di reali interazioni nativo-non nativo. I contributi qui raccolti sono ispirati alla CA ma anche ad altri filoni di ricerca, con la consapevolezza dell’importanza degli studi e degli approcci che si fondano sull’analisi di dati reali.
description: RiCOGNIZIONI, V. 4 N. 8 (2017)
I CORPORA DI L2 COME SPUNTI PER LA RIFLESSIONE DIDATTICA. L’INTERAZIONE NATIVO-NON NATIVO NEL PERCORSO FORMATIVO DEGLI INSEGNANTII
Creators: name: Cacchione, Annamaria
name: Borreguero Zuloaga, Margarita
Publisher: name: RiCOGNIZIONI
Year: 2018

description: This contribution describes an experimentation conducted with a Master degree group of students at the Complutense University of Madrid, in order to observe their capability to identify a series of textual and phrasal connectives in Italian as L2 through the analysis of three texts (of different linguistic levels) extracted from the A.Ma.Dis corpus. The data show that the intervention was a successful inductive and corpus-based learning experience, and that the students were able to identify and classify connective elements quite correctly. Data collected by the students also show a clear convergence between the increase of the number and variety of connectives used by non natives and the improvment of their global proficiency.
description: RiCOGNIZIONI, V. 4 N. 8 (2017)