cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Long-run savings associated with surgical aortic valve replacement using a RESILIA tissue bioprosthetic valve versus a mechanical valve
Creators: name: Keuffel, Eric L.
name: Reifenberger, Matt
name: Marfo, Godfred
name: Nguyen, Tom C.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Prior economic analyses demonstrate that legacy tissue valves are associated with substantial financial savings over the long run after a surgical aortic valve replacement (SAVR). Bioprostheses with RESILIA tissue reduce calcification, the primary cause of structural valve deterioration (SVD), and have demonstrated promising pre-clinical and 5-year clinical results. This economic evaluation quantifies the expected long-run savings of bioprosthetic valves with RESILIA tissue relative to mechanical valves given 5-year clinical results and expected performance through year 15. Simulation models estimated disease progression across two hypothetical SAVR cohorts (tissue vs. mechanical) of 10,000 patients in the US over 15 years. One comparison evaluated RESILIA tissue valves relative to mechanical valves. The other compared legacy SAVR tissue and mechanical valves. Health outcome probabilities and costs were based on literature and expert opinion. Incidence rates of health outcomes associated with mechanical valve were calculated using relative risks of expected outcomes in tissue valve versus mechanical valve patients. The comparisons also accounted for anti-coagulation monitoring in both cohorts. Savings estimates are based on US healthcare costs and do not yet account for the premium associated use of RESILIA relative to a standard tissue valve. Relative to mechanical SAVR, the median net discounted savings for a patient receiving SAVR with a RESILIA tissue valve is $20,744 ($US, 2020; 95% CI = $15,835–$26,655) over a 15-year horizon. While 30-day and 1-year savings were not significant, expected savings after 5 years are $9,110 (95% CI = $6,634–$11,969). Net savings for RESILIA SAVR valves were approximately 30–50% larger than savings anticipated using legacy tissue SAVR valves. RESILIA tissue valves are associated with lower health expenditures relative to mechanical valves.
Additional file 1: of A real options approach to renewable electricity generation in the Philippines
Creators: name: Agaton, Casper
name: Karl, Helmut
Publisher: name: figshare
Year: 2018
Subjects: subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Table S1. ADF unit root test result of oil prices from 1981-2016. Table S2. Note: elec+2_0: option values at 25% higher electricity price than the base at the initial period; elec+2_T: option values at 25% higher electricity price than the base at the terminal period elec+1_0: option values at 10% higher electricity price than the base at the initial period; elec+1_T: option values at 10% higher electricity price than the base at the terminal period; base_0: option values of energy investment at the initial period; base_T: option values of energy investment at the terminal period; elec-1_0: option values at 10% lower electricity price than the base at the initial period; elec-1_T: option values at 10% lower electricity price than the base at the terminal period; elec-2_0: option values at 25% lower electricity price than the base at the initial period; elec-2_T: option values at 25% lower electricity price than the base at the terminal period; elec-3_0: option values at 40% lower electricity price than the base at the initial period; elec-3_T: option values at 40% lower electricity price than the base at the terminal period. Table S3. base_0: option values of energy investment with no externality at the initial period; base_T: option values of energy investment with no externality at the terminal period; ex1_0: option values at 20/MWhexternalitycosttheinitialperiod; ex1T: optionvaluesat20/MWh externality cost at the terminal period; ex2_0: option values at 40/MWhexternalitycosttheinitialperiod; ex2T: optionvaluesat40/MWh externality cost at the terminal period; ex3_0: option values at 60/MWhexternalitycosttheinitialperiod;ex3T: optionvaluesat60/MWh externality cost at the terminal period; ex3_0: option values at 80/MWhexternalitycosttheinitialperiod; ex4T: optionvaluesat80/MWh externality cost at the terminal period. (DOCX 95 kb)
Light-hole Exciton in Nanowire Quantum Dot
Creators: name: Jeannin, Mathieu
name: Artioli, Alberto
name: Rueda-Fonseca, Pamela
name: Bellet-Amalric, Edith
name: Kheng, Kuntheak
name: André, Régis
name: Tatarenko, Serge
name: Cibert, Joël
name: Ferrand, David
name: Nogues, Gilles
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Quantum dots inserted inside semiconductor nanowires are extremely promising candidates as building blocks for solid-state based quantum computation and communication. They provide very high crystalline and optical properties and offer a convenient geometry for electrical contacting. Having a complete determination and full control of their emission properties is one of the key goals of nanoscience researchers. Here we use strain as a tool to create in a single magnetic nanowire quantum dot a light-hole exciton, an optically active quasiparticle formed from a single electron bound to a single light hole. In this frame, we provide a general description of the mixing within the hole quadruplet induced by strain or confinement. A multi-instrumental combination of cathodoluminescence, polarisation-resolved Fourier imaging and magneto-optical spectroscopy, allow us to fully characterize the hole ground state, including its valence band mixing with heavy hole states.
title: World History Connected, Vol. 21 No. 1: Winter 2024
title: Winter 2024
titleType: AlternativeTitle
Creators: name: World History Connected
Publisher: name: World History Connected
Year: 2024

description: Looking Back, Moving Forward: Two Decades of World History Research and Pedagogy

A retrospective issue of ten articles selected by members of the Advisory Board, Editorial Board, Editorial Staff, and Readers that showcases a small sampling of the exceptional scholarship that has made World History Connected a vital publication in World History.
description: Jim Downs, Maladies of Empire: How Colonialism, Slavery, and War Transformed Medicine
World History Connected Turns Twenty
Stewart Gordon, A History of the World in Seven Themes, Two Volumes
Julián Casanova, A Short History of the Spanish Civil War and Giles Tremlett, The International Brigades: Fascism, Freedom and the Spanish Civil War
Philip Dwyer and Mark Micale, Eds., The Darker Angels of Our Nature: Refuting the Pinker Theory of History and Violence
Jennifer L. Morgan, Reckoning with Slavery: Gender, Kinship, and Capitalism in the Early Black Atlantic
The Walrus and the Emperor: Materials, Miracles, and Memory in the Early Modern Persian Cosmopolis
Fast Food for Thought: Finding Global History in a Beijing McDonald’s
Digital Resources for Teaching World History with Cinema and Film
Beyond the Scramble: African Veterans, the Second World War and Decolonization in the World History Classroom
War and the Environment
Manuela Sáenz and the Independence of South America
Contingency, Pattern and the S-curve in Human History
Teaching Gender in the World History Classroom
So Many Africas, So Little Time: Doing Justice to Africa in the World History Survey
World History Makeover: The French Revolution
Brief Summary of the Issue
A biomechanic comparison of knees: healthy vs medial pivot total knee arthroplasty
Creators: name: Thoms, Peter
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The purpose of this study is to investigate and analyse the biomechanical differences between a healthy knee and a post total knee arthroplasty (TKA) knee.The aim of undertaking such an analysis is to identify areas of design or performance deficiencies of TKA implants which can, in future, be improved upon to reduce patient dissatisfaction, pain and failure rates and to further improve the function and longevity of the joint.This was achieved by performing 3D gait analysis on a healthy cohort of participants and a patient cohort 6 months after knee replacement surgery. A medial pivot knee TKA implant was applied to the patient cohort. The gait observed included both level walking and stair ascent/descent performed at a self-paced speed. This was done using an array of infrared motion tracking cameras and ground embedded force plates which allowed for a kinematic and kinetic analysis of motion, respectively. The study found that medial pivot TKA does allow for certain biomechanics and gait patterns to replicate those of healthy knees. This study faced time constraints and sample size limitations. These were remedied with process automation and revising methodological protocols to increase the efficiency of data acquisition. Future works can aim to improve on the findings of this report by testing a larger sample size and investigating with a broader scope to compile a more comprehensive analysis of healthy and TKA gait.
MPEC 2024-N106 : COMET P/2024 L4 (Rankin)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: COMET P/2024 L4 (Rankin)

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
VIP-2 at LNGS: An experiment on the validity of the Pauli Exclusion Principle for electrons
Creators: name: Marton, J.
name: Bartalucci, S.
name: Bassi, A.
name: Bazzi, M.
name: Bertolucci, S.
name: Berucci, C.
name: Bragadireanu, M.
name: Cargnelli, M.
name: Clozza, A.
name: Curceanu, C.
name: De Paolis, L.
name: Di Matteo, S.
name: Donadi, S.
name: Egger, J. -P.
name: Guaraldo, C.
name: Iliescu, M.
name: Laubenstein, M.
name: Milotti, E.
name: Pichler, A.
name: Pietreanu, D.
name: Piscicchia, K.
name: Scordo, A.
name: Shi, H.
name: Sirghi, D.
name: Sirghi, F.
name: Sperandio, L.
name: Vazquez-Doce, O.
name: Widmann, E.
name: Zmeskal, J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We are experimentally investigating possible violations of standard quantum mechanics predictions in the Gran Sasso underground laboratory in Italy. We test with high precision the Pauli Exclusion Principle and the collapse of the wave function (collapse models). We present our method of searching for possible small violations of the Pauli Exclusion Principle (PEP) for electrons, through the search for anomalous X-ray transitions in copper atoms. These transitions are produced by new electrons (brought inside the copper bar by circulating current) which can have the possibility to undergo Pauli-forbidden transition to the 1s level already occupied by two electrons. We describe the VIP2 (VIolation of the Pauli Exclusion Principle) experimental data taking at the Gran Sasso underground laboratories. The goal of VIP2 is to test the PEP for electrons in agreement with the Messiah-Greenberg superselection rule with unprecedented accuracy, down to a limit in the probability that PEP is violated at the level of 10E-31. We show preliminary experimental results and discuss implications of a possible violation.
description: Proc. DISCRETE2016
MOESM1 of Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model
Creators: name: Piubeli, Francine
name: Salvador, Manuel
name: Argandoña, Montserrat
name: Nieto, Joaquín
name: Bernal, Vicente
name: Jose Pastor
name: Cánovas, Manuel
name: Vargas, Carmen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Inorganic Chemistry
subject: Computational Biology

description: Additional file 1: Table S1. Biomass composition at high salinity (´´BIO_H``). Table S2. Biomass composition at low salinity (´´BIO_L``); Table S3. Composition of M63 minimal medium and the exchange reactions formulated to simulate the uptake of metabolites from medium; Table S4. In silico (computational) constraints used for simulation at high or low salinity; Description of the bottom-up building and exhaustive manual refinement of the C. salexigens metabolic reconstruction iFP764; Table S5. The total number of dead ends metabolites found in the iFP764 model: root no-production metabolites and root no-consumption metabolites; Table S6. In silico prediction of utilization of various metabolites as carbon sources in C. salexigens; Figure S1. Selected histograms of possible flux values obtained in the first scenario by Monte Carlo sampling at low and high salinity relative to salinity-specific glucose consumption rate.
Leading Through Change: Preserving Business Continuity While Driving Transformation
Creators: name: Carreno, Adolfo M.
Publisher: name: Institute for Change Leadership and Business Transformation
Year: 2024

description: Organizations undergoing transformation face a significant challenge: driving innovation while maintaining business continuity. This white paper explores how effective leaders navigate this balance to ensure resilience, stability, and sustainable growth. With increased pressure to adopt digital solutions and respond to changing market conditions, leaders must foster innovation without disrupting critical operations. Strategies such as contingency planning, proactive risk mitigation, and cultural continuity are highlighted to stabilize the workforce and maintain core functions during change. By engaging employees actively in the process, leaders can cultivate a culture of ownership and adaptability, reducing resistance to new initiatives.The article also presents examples from companies like Maersk and Best Buy, demonstrating how strategic alignment and phased innovation can strengthen competitiveness without undermining operational stability. It argues that the key to thriving in dynamic environments is aligning transformation with a clear long-term vision and preserving essential operations. Leaders who strike this balance are better equipped to guide their organizations through change, ensuring readiness for future disruptions while achieving sustainable growth.
Multiplicative equations related to the affine Weyl group E$_8$
Creators: name: Grammaticos, Basil
name: Ramani, Alfred
name: Willox, Ralph
name: Satsuma, Junkichi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: We derive integrable equations starting from autonomous mappings with a general form inspired by the multiplicative systems associated to the affine Weyl group E$_8^{(1)}$. Five such systems are obtained, three of which turn out to be linearisable and the remaining two are integrable in terms of elliptic functions. In the case of the linearisable mappings we derive nonautonomous forms which contain a free function of the dependent variable and we present the linearisation in each case. The two remaining systems are deautonomised to new discrete Painlevé equations. We show that these equations are in fact special forms of much richer systems associated to the affine Weyl groups E$_7^{(1)}$ and E$_8^{(1)}$ respectively.
description: 9 pages, no figures
Supplementary document for A band engineering method to create Dirac cones of accidental degeneracy in general photonic crystals without symmetry - 5250897.pdf
Creators: name: Yun, Lai
name: Chu, Hongchen
name: Zhang, Yang
name: luo, jie
name: Xu, Changqing
name: Xiong, Xiang
name: Peng, Ruwen
name: Wang, Mu
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Detailed design processes of the first example
Magnetic fields in star forming environments: how does field strength affect gas on spiral arm and cloud scales?
Creators: name: Herrington, Nicholas P.
name: Dobbs, Clare L.
name: Bending, Thomas J. R.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate star formation from subparsec to kpc scales with magnetohydrodynamic (MHD) models of a cloud structure and a section of galactic spiral arm. We aim to understand how magnetic fields affect star formation, cloud formation and how feedback couples with magnetic fields on scales of clouds and clumps. We find that magnetic fields overall suppress star formation by $\sim$10% with a weak field (5 $μ$G), and $\sim50$% with a stronger field (50 $μ$G). Cluster masses are reduced by about 40% with a strong field but show little change with a weak field. We find that clouds tend to be aligned parallel to the field with a weak field, and become perpendicularly aligned with a stronger field, whereas on clump scales the alignment is more random. The magnetic fields and densities of clouds and clumps in our models agree with the Zeeman measurements of the Crutcher relation $B-ρ$ in the weaker field models, whilst the strongest field models show a relation which is too flat compared to the observations. In all our models, we find both subcritical and supercritical clouds and clumps are present. We also find that if using a line of sight (1D) measure of the magnetic field to determine the critical parameter, the magnetic field, and thereby also criticality, can vary by a factor of 3-4 depending on whether the direction the field is measured along corresponds to the direction of the ordered component of the magnetic field.
description: 15 pages, 12 figures
Additional file 1: of HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible: study protocol for a randomised controlled trial
Creators: name: Shaw, Richard
name: Butterworth, Christopher
name: Binyam Tesfaye
name: Bickerstaff, Matthew
name: Dodd, Susanna
name: Smerdon, Gary
name: Chauhan, Seema
name: Brennan, Peter
name: Webster, Keith
name: McCaul, James
name: Nixon, Peter
name: Kanatas, Anastasios
name: Silcocks, Paul
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 121Â kb)
Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer
Creators: name: Xie, Zixin
name: Cheng, Donghua
name: Luo, Lu
name: Shen, Guoliang
name: Pan, Suwei
name: Pan, Yaqian
name: Chen, Bo
name: Wang, Xuebao
name: Liu, Zhiguo
name: Zhang, Yuan
name: Ye, Faqing
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A series of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives were designed and synthesised as novel fibroblast growth factor receptor-1 (FGFR1) inhibitors. We found that one of the most promising compounds, C9, inhibited five non-small cell lung cancer (NSCLC) cell lines with FGFR1 amplification, including NCI-H520, NCI-H1581, NCI-H226, NCI-H460 and NCI-H1703. Moreover, the IC50 values for the compound C9 were 1.36 ± 0.27 µM, 1.25 ± 0. 23 µM, 2.31 ± 0.41 µM, 2.14 ± 0.36 µM and 1.85 ± 0.32 µM, respectively. The compound C9 arrested the cell cycle at the G2 phase in NSCLC cell lines. The compound C9 also induced cellular apoptosis and inhibited the phosphorylation of FGFR1, PLCγ1 and ERK in a dose-dependent manner. In addition, molecular docking experiments showed that compound C9 binds to FGFR1 to form six hydrogen bonds. Taken together, our data suggested that the compound C9 represented a promising lead compound-targeting FGFR1.
Supplementary_Materials_and_Interactive_Map
Creators: name: Silva, F.G.
name: Santos, A.R.
name: Fiedler, N.C.
name: Paes, J.B.
name: Guerra Filho, P.A.
name: Silva, R.G.
name: Moura, M.M.
name: Silva, E.F.
name: Silva, S.G.O.S.R.
name: Cessa, R.M.A.
name: Ferreira, W.A.
name: Marinho, F.G.
Publisher: name: Zenodo
Year: 2022

description: Supplementary figures S1, S2, S3 and S4 with respective captions. Interactive Map of the studied area.
Additional file 15 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer
Creators: name: Lin, Dagui
name: Fan, Wenhua
name: Zhang, Rongxin
name: Zhao, Enen
name: Li, Pansong
name: Zhou, Wenhao
name: Peng, Jianhong
name: Li, Liren
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 15: Figure S8. Validation of the nomogram in the entire dataset.
Optimal transport and integer partitions
Creators: name: Hohloch, Sonja
Publisher: name: arXiv
Year: 2017
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 05A17, 11P81, 11P84, 28A25, 49J99, 49K99

description: We link the theory of optimal transportation to the theory of integer partitions. Let $\mathscr P(n)$ denote the set of integer partitions of $n \in \mathbb N$ and write partitions $π\in \mathscr P(n)$ as $(n_1, \dots, n_{k(π)})$. Using terminology from optimal transport, we characterize certain classes of partitions like symmetric partitions and those in Euler's identity $|\{ π\in \mathscr P(n) |$ all $ n_i $ distinct $ \} | = | \{ π\in \mathscr P(n) | $ all $ n_i $ odd $ \}|$. Then we sketch how optimal transport might help to understand higher dimensional partitions.
description: 21 pages, 7 figures; In accordance with the journal's copyright, I am making a preprint version of my published paper available on the ArXiv
MOESM3 of Host-specific differences in the response of cultured macrophages to Campylobacter jejuni capsule and O-methyl phosphoramidate mutants
Creators: name: Sungwon Kim
name: Vela, Andrea
name: Clohisey, Sara
name: Athanasiadou, Spiridoula
name: Kaiser, Pete
name: Stevens, Mark
name: Vervelde, Lonneke
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Analysis of TLR4 transcription in chBMMs stimulated wild-type C. jejuni and capsule or MeOPN mutants. Live or fixed C. jejuni 11168H (WT), Δcj1417 (MeOPN) and Δcj1439 (capsule) mutants were incubated with chBMMs at MOI 50 for 3 h. Salmonella LPS (100 ng/mL) was used as a positive control and PBS in the medium as a negative control. Graphs show representative results of three independent experiments, and error bars are the standard deviation of three independent experiments. Asterisks indicate a statistically significant difference of TLR4 transcripts compared to PBS in the medium (P
Cost-effectiveness of a novel, non-active implantable device as a treatment for refractory gastro-esophageal reflux disease
Creators: name: Harper, Sam
name: Grodzicki, Lukasz
name: Mealing, Stuart
name: Gemmill, Liz
name: Goldsmith, Paul J.
name: Ahmed, Ahmed R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Gastro-esophageal reflux disease (GERD) is a common, chronic gastrointestinal condition characterized by heartburn, chest pain, regurgitation, and bloating. The current standard of care includes chronic treatment with proton pump inhibitors (PPIs) or, in selected patients, laparoscopic anti-reflux surgery. RefluxStop is a novel implantable device indicated for GERD patients eligible for laparoscopic surgical treatment. The aim of this analysis was to assess the cost-effectiveness of RefluxStop against available treatment options for GERD. A Markov model was developed to assess the cost-effectiveness of RefluxStop compared with PPI-based medical management (MM) and two surgical management options, LNF and magnetic sphincter augmentation (MSA, LINX system), in people with GERD. Clinical outcomes and costs were estimated over a lifetime horizon from the UK National Health Service perspective and an annual discount rate of 3.5% was applied. RefluxStop showed favorable surgical outcomes compared with both LNF and MSA. The base case incremental cost-effectiveness ratios compared with MM, LNF, and MSA were £4,156, £6,517, and £249 per QALY gained, respectively. At the UK cost-effectiveness threshold of £20,000 per QALY gained, the probability that RefluxStop was cost-effective against MM, LNF, and MSA was 100%, 93%, and 100%, respectively. The model presented the results of a comparison, with evidence for RefluxStop derived from its single-arm CE mark trial and that for comparators from the literature. The varied clinical care pathway of individual GERD patients was necessarily simplified for modeling purposes, and necessary assumptions were made; however, the model results proved robust to sensitivity analyses. Introduction of RefluxStop was estimated to extend life expectancy and improve quality-of-life of GERD patients when compared with MM, LNF, and MSA. The results of the cost-effectiveness analysis demonstrated that RefluxStop is highly likely to be a cost-effective treatment option within NHS England.
Goddess Durgā's Triumph in the Hindu Pantheon - Acharya Dr. Sthaneshwar Timalsina
Creators: name: Timalsina, Staneshwar
Publisher: name: Zenodo
Year: 2023
Subjects: Tantric philosophy
anava upaya
yantra
amnaya
Shiva
Shaiva
vimarsha-foundation
consciousness
mahadeva
Vasugupta
Sarvamnaya
tripura
Durga
Kaula
Abhinavagupta
Shiva Sutra
Kula
saivadvaita
vedanta
Mahakali
Tantra
Chandi
Kali
advaita vedanta
Bhairava
shambhava
timalsina
Spanda
Kashmir Shaivism
krama
Saundaryalahari
Tripura Rahasya
Tripurasundari
Camunda
agama
Devi Mahatmya
sarvamnaya
Guhyakālī
shakti
tantraloka
Divine Mother
sarvamnaya-oral-tradition-archive
trika
sthaneshwar timalsina
Īśāna
Mālinīvijayottaratantra
shakta upāya
Kubjika
Sadāśiva

description: Acharya Dr. Sthaneshwar Timalsina is an esteemed traditional consecrated teacher of Shaiva-Shakta Hindu Tantra. He is also the Endowed Chair of Indic Studies at Stony Brook University, New York in the Department of Asian & Asian American Studies. Acharya Sthaneshwar is the founder of Vimarsha Foundation, a non-profit organization through which he teaches shāstra and sādhanā to students of all backgrounds. Learn more about Vimarsha on our website, learn from our many free Tantra resources, and join us for free shāstra courses that occur every semester: https://www.vimarshafoundation.org/

This video is an excerpt of a talk that Acharyaji delivered to Global Mandala during Navaratri the previous year. Watch the full discussion from our Talks Playlist: https://youtube.com/playlist?list=PLfbgwkldU93cgwIqN6g0cQZcqP5OlK6un&si=iGMF9Od21LLra0v7.

#tantra #shaktism #durga #hinduism #navratri

Original YouTube video: https://www.youtube.com/watch?v=Z3qDGTPyrAU

This presentation is part of the Sarvāmnāya Oral Tradition Archive.
Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
Continuous body dynamics and the Mathisson-Papapetrou-Dixon equations
Creators: name: Loomis, S. P.
name: Brown, J. David
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show that an effective particle Lagrangian yields the Mathisson-Papapetrou-Dixon (MPD) equations. The spin of the effective particle is defined without any reference to a fixed body frame or angular velocity variable. We then demonstrate that a continuous body, defined by a congruence of world lines and described by a general action, can be rewritten as an effective particle. We analyze the gauge freedom of the body and show that a natural center of mass condition is related to a spin supplementary condition.
Theodosius II and his image: three case studies in imperial presentation, ceremonial and reception
Creators: name: Kujanpaa, Alexandra Lee
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Theodosius II (402-450 AD) was a non-campaigning sedentary emperor who lived and ruled the majority of his life within the city walls of Constantinople. He was orphaned and became sole Emperor at aged seven after the death of his father, Arcadius, in 408 and would continue to reign in the East successfully for a further forty-two years. Despite the limitations and anxieties associated with child-emperor rule, there is no clear evidence to suggest his position was ever contested nor his role as emperor ever questioned. This thesis will analyse three key components of the emperor’s reign to consider how the Eastern Theodosian regime first adapted and later developed traditional imperial presentation to better suit their unique situation of an emperor ruling the empire from such a young age without any adult familial support. The first case study examines the contemporary presentation and long-term reception of the public image of the Eastern branch of the Theodosian family. It will highlight the earliest identifiable establishment of this image in 414, after the proclamation of perpetual virginity by the emperor’s sisters and Pulcheria’s elevation to Augusta, and assess how it grew and developed alongside the family. The second case study assesses, through five examples, the active role Theodosius II played in the ceremonial life of Constantinople. It will highlight not only how this emperor reinvented traditional elements in imperial performance, but will also show the consistent portrayal of his behaviour in the sources that range from contemporary accounts to the ninth century. Finally, the third case study analyses the portrayal of Theodosius II as the father figure to Western emperor Valentinian III, his young cousin. This case study assesses three key events, the Eastern military expedition to install Valentinian III onto the Western throne between 424 and 425, the marriage of Theodosius II’s only surviving child, Licinia Eudoxia to the Western emperor in 437, and the proclamation of the Theodosian Code a year later, to show the ongoing development of this image throughout this period. Through these three case studies, this thesis will argue that Theodosius II was not only an active participant in his long reign, but also successfully established a new form of active leadership – one based primarily within the imperial city and amongst its citizenry.
Study of cryogenic photomultiplier tubes for the future two-phase cryogenic avalanche detector
Creators: name: Bondar, A.
name: Buzulutskov, A.
name: Dolgov, A.
name: Frolov, E.
name: Nosov, V.
name: Shekhtman, L.
name: Sokolov, A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We report the results of a characterization study of several types of cryogenic photomultipliers manufactured by Hamamatsu Photonics and intended for operation in liquid Ar conditions, namely: compact 2-inch R6041-506MOD tubes, 3-inch R11065-10 and R11065-MOD tubes for operation in liquid Ar and 3-inch R11410-20 tubes originally designed for operation in liquid Xe. These types of PMT are proposed for installation into the future two-phase cryogenic avalanche detector that is developed in the Laboratory of Cosmology and Particle Physics of the Novosibirsk State University jointly with the Budker Institute of Nuclear Physics. Eight R11065 PMTs and seven R11410-20 tubes were tested and all demonstrated excellent performance in liquid Ar in terms of gain and relative single electron efficiency. All 3-inch PMTs showed a maximal gain in liquid Ar above 5x10^6 and relative single electron efficiency higher than 95%. Compact R6041-506MOD tubes have dynode system different from that of the 3-inch photomultipliers and thus their single electron energy resolution and relative efficiency is much worse than that of 3-inch tubes. From 21 2-inch PMTs only 12 tubes were selected with acceptable, i.e. higher than 75%, relative single electron efficiency and the maximal gain higher than 5x10^6. However, these PMTs are very attractive because they are the only compact type of tubes that can operate in liquid Ar.
description: Submitted to the Proceedings of the Instrumentation for Colliding Beam Physics INSTR17 Conference, to be published in JINST
title: Bol (Inv. 2014.34.1009.39) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: bol

description: Forme  couleur et décor sont autant d’indices qui permettent à l’archéologue de préciser l’usage d’une poterie ou sa date de fabrication. Les jarres de grande taille servent au stockage. Les récipients plus petits  à la paroi épaisse et noircie  sont des pots à cuire. La vaisselle de table présente une plus grande diversité. Les pots à boisson aux formes élancées et aux surfaces sombres de style gaulois laissent progressivement la place à des cruches à pâte plus claire pourvues d’une ou deux anses. Les plats et assiettes dénotent très tôt l’influence romaine. L’évolution de leur forme suit de près celle de la céramique à vernis noir (“campanienne”) et à vernis rouge (“sigillée”) dont elle s’inspire.
Time-delayed model of RNA interference
Creators: name: Neofytou, G.
name: Kyrychko, Y. N.
name: Blyuss, K. B.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Chaotic Dynamics (nlin.CD)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence against pathogens to regulating development and morphogenesis. In this paper we consider a mathematical model of RNAi with particular emphasis on time delays associated with two aspects of primed amplification: binding of siRNA to aberrant RNA, and binding of siRNA to mRNA, both of which result in the expanded production of dsRNA responsible for RNA silencing. Analytical and numerical stability analyses are performed to identify regions of stability of different steady states and to determine conditions on parameters that lead to instability. Our results suggest that while the original model without time delays exhibits a bi-stability due to the presence of a hysteresis loop, under the influence of time delays, one of the two steady states with the high (default) or small (silenced) concentration of mRNA can actually lose its stability via a Hopf bifurcation. This leads to the co-existence of a stable steady state and a stable periodic orbit, which has a profound effect on the dynamics of the system.
description: 31 pages, 11 figures, accepted for publication to Ecological Complexity
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00406
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00406, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Cross-stream migration of a surfactant-laden deformable droplet in a Poiseuille flow
Creators: name: Das, Sayan
name: Mandal, Shubhadeep
name: Chakraborty, Suman
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The motion of a viscous deformable droplet suspended in an unbounded Poiseuille flow in the presence of bulk-insoluble surfactants is studied analytically. Assuming the convective transport of fluid and heat to be negligible, we perform a small-deformation perturbation analysis to obtain the droplet migration velocity. The droplet dynamics strongly depends on the distribution of surfactants along the droplet interface, which is governed by the relative strength of convective transport of surfactants as compared with the diffusive transport of surfactants. The present study is focused on the following two limits: (i) when the surfactant transport is dominated by surface diffusion, and (ii) when the surfactant transport is dominated by surface convection. In the first limiting case, it is seen that the axial velocity of the droplet decreases with increase in the advection of the surfactants along the surface. The variation of cross-stream migration velocity, on the other hand, is analyzed over three different regimes based on the ratio of the viscosity of the droplet phase to that of the carrier phase. In the first regime the migration velocity decreases with increase in surface advection of the surfactants although there is no change in direction of droplet migration. For the second regime, the direction of the cross-stream migration of the droplet changes depending on different parameters. In the third regime, the migration velocity is merely affected by any change in the surfactant distribution. For the other limit of higher surface advection in comparison to surface diffusion of the surfactants, the axial velocity of the droplet is found to be independent of the surfactant distribution. However, the cross-stream velocity is found to decrease with increase in non-uniformity in surfactant distribution.
Asymptotically Locally Optimal Weight Vector Design for a Tighter Correlation Lower Bound of Quasi-Complementary Sequence Sets
Creators: name: Liu, Zilong
name: Guan, Yong Liang
name: Mow, Wai Ho
Publisher: name: arXiv
Year: 2017
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: A quasi-complementary sequence set (QCSS) refers to a set of two-dimensional matrices with low non-trivial aperiodic auto- and cross- correlation sums. For multicarrier code-division multiple-access applications, the availability of large QCSSs with low correlation sums is desirable. The generalized Levenshtein bound (GLB) is a lower bound on the maximum aperiodic correlation sum of QCSSs. The bounding expression of GLB is a fractional quadratic function of a weight vector $\mathbf{w}$ and is expressed in terms of three additional parameters associated with QCSS: the set size $K$, the number of channels $M$, and the sequence length $N$. It is known that a tighter GLB (compared to the Welch bound) is possible only if the condition $M\geq2$ and $K\geq \overline{K}+1$, where $\overline{K}$ is a certain function of $M$ and $N$, is satisfied. A challenging research problem is to determine if there exists a weight vector which gives rise to a tighter GLB for \textit{all} (not just \textit{some}) $K\geq \overline{K}+1$ and $M\geq2$, especially for large $N$, i.e., the condition is {asymptotically} both necessary and sufficient. To achieve this, we \textit{analytically} optimize the GLB which is (in general) non-convex as the numerator term is an indefinite quadratic function of the weight vector. Our key idea is to apply the frequency domain decomposition of the circulant matrix (in the numerator term) to convert the non-convex problem into a convex one. Following this optimization approach, we derive a new weight vector meeting the aforementioned objective and prove that it is a local minimizer of the GLB under certain conditions.
title: Bol (Inv. 2014.34.1009.39)
Creators: name:  Bavay, Laurent
name: Vitali, Daniele
name: Fochesato, Andrea
name: Martin, Fanny
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: bol
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica
Creators: name: Wu, Rui-Fang
name: Wang, Wen-Qiong
name: Zhou, Bing-Duo
name: Wang, Yi
name: Li, Ya-Ding
name: Zhu, Sheng-Liang
name: Xuan, Li-Jiang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Phytochemical investigation on the 95% alcohol extract of the aerial part of Inula japonica led to the isolation of three new compounds, inulanolides F-G (1-2) and 17α-carboxaldehyde-ent-kaur-18-oic acid (3), together with four known compounds (4–7). The structures of new compounds were elucidated by using spectroscopic data. Most of the isolated compounds showed significant anti-inflammatory activities.
Polar questions in Bahasa Indonesia: a pilot study
Creators: name: Hamdani, Fakry
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Polar questions (i.e., questions that can take a “yes” or a “no” response) are formed in a variety of ways across the world’s languages. In Bahasa Indonesia, polar questions in spoken language are realised in two ways: unmarked polar questions and marked polar questions. Unmarked polar questions do not involve any morphosyntactic or lexical resources to indicate questionhood. In contrast, marked polar questions are formed using final particles, namely ya,kan, sih, dong, lho/loh, toh, tah. This study explores polar questions in everyday conversation in Bahasa Indonesia, focusing on unmarked questions, and questions marked with ya and kan. It uses principles and practices derived from conversation analysis to explore interactions in Bahasa Indonesia. 12 Bahasa-speaking people were recruited to participate, yielding a corpus of 2 hours and 7 minutes of video recordings for analysis. Analysis focuses on the epistemic characteristics of unmarked and marked polar questions. Unmarked polar questions realised the strongest epistemic asymmetry, casting the question recipient as the knowledgeable party. Polar questions marked with the particle ya also realised an epistemic asymmetry, but they indexed a more knowing epistemic stance on the part of the speaker. Polar questions marked with kan indexed a more symmetrical distribution of knowledge between the speaker and the recipient. The findings of this study contribute to knowledge on the functions of final particles in Bahasa, and more generally. Future studies should explore other question particles in Bahasa, and compare other functions of ya and kan.
Joint Maximum a Posteriori State Path and Parameter Estimation in Stochastic Differential Equations
Creators: name: Dutra, Dimas Abreu Archanjo
name: Teixeira, Bruno Otávio Soares
name: Aguirre, Luis Antonio
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: In this article, we introduce the joint maximum a posteriori state path and parameter estimator (JME) for continuous-time systems described by stochastic differential equations (SDEs). This estimator can be applied to nonlinear systems with discrete-time (sampled) measurements with a wide range of measurement distributions. We also show that the minimum-energy state path and parameter estimator (MEE) obtains the joint maximum a posteriori noise path, initial conditions, and parameters. These estimators are demonstrated in simulated experiments, in which they are compared to the prediction error method (PEM) using the unscented Kalman filter and smoother. The experiments show that the MEE is biased for the damping parameters of the drift function. Furthermore, for robust estimation in the presence of outliers, the JME attains lower state estimation errors than the PEM.