cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hydration phenomena in concentrated protein solutions
Creators: name: Jahn, Niklas Henning
Publisher: name: Imperial College London
Year: 2015

description: The transport of water in glassy polymers is important in many fields but an underappreciated topic in protein science; though proteins are of rising importance in many industries. Similar to water transport in synthetic polymers, glassy proteins suffer from non-equilibrium effects during water sorption. However, the presence (or absence) of these phenomena is unclear. Here and for the first time, experimental evidence is reported for the presence and consequences of non-equilibrium relaxations during water sorption in proteins over long time scales based on gravimetric and calorimetric experiments. Non-Fickian water sorption kinetics were found in all experiments. It is demonstrated how water solubility in a glassy protein is highly dependent on experimental design and time scales. The apparent sorption kinetics were attributed to the convolution of two processes: one that is controlled by the concentration gradient; one that is driven by a slow relaxation of the protein. A relaxation−diffusion model was employed to model sorption kinetics and the respective time constants were estimated. Exothermic heats of mixing, that were both temperature and concentration dependent, were measured. Enthalpy of mixing time evolution data was in excellent agreement with gravimetric sorption kinetics. The plasticising effect of water onto the protein was further shown by differential scanning calorimetry of concentrated protein solutions. All this demonstrates the unsuitability of long established surface and lattice approaches to model or predict water sorption in proteins. Protein pressure−volume isotherms were obtained and used to model a protein’s water sorption isotherms by the non-equilibrium lattice fluid theory for the first time. It is anticipated that this work stimulates a revaluation of the design of water sorption experiments in glassy proteins and the interpretation of such data. This in turn is expected to profoundly affect formulation engineering and Quality-by-Design approaches for a wide range of protein-based products.
NEXT STEP
Creators: name: VIVIER Frédéric
Publisher: name: Sismer
Year: 2016

description: L'objectif de la série de campagnes "NEXT STEP" (briNe formation in a warming world: EXTending the STorfjordEn Polynya time series) est de poursuivre la série temporelle unique documentant la formation d'eau dense par rejet de saumures dans le Storfjorden. Ces observations, initiées en 2011, sont essentielles pour documenter l'impact du réchauffement rapide et de grande ampleur, actuellement en cours dans les régions arctiques sur la formation d¿eaux denses et le flux air-mer de CO2 qui lui y est associé. Elles sont complémentaires des travaux d'observation en cours dans la mer de Barents (projet norvégien "Nansen Legacy") et le détroit de Nares (projet franco-canadien "Refuge Arctic"). Nous souhaitons donc assurer la continuité de la série chronologique de suivi de la formation d'eau dense dans le Storfjorden au cours des 5 à 10 prochaines années.
Electric-field Inputs for Molecular Quantum-dot Cellular Automata Circuits
Creators: name: Blair, Enrique P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Emerging Technologies (cs.ET)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Quantum-dot cellular automata (QCA) is a low-power, non-von-Neumann, general-purpose paradigm for classical computing using transistor-free logic. An elementary QCA device called a "cell" is made from a system of coupled quantum dots with a few mobile charges. The cell's charge configuration encodes a bit, and quantum charge tunneling within a cell enables device switching. Arrays of cells networked locally via the electrostatic field form QCA circuits, which mix logic, memory and interconnect. A molecular QCA implementation promises ultra-high device densities, high switching speeds, and room-temperature operation. We propose a novel approach to the technical challenge of transducing bits from larger conventional devices to nanoscale QCA molecules. This signal transduction begins with lithographically-formed electrodes placed on the device plane. A voltage applied across these electrodes establishes an in-plane electric field, which selects a bit packet on a large QCA input circuit. A typical QCA binary wire may be used to transmit a smaller bit packet of a size more suitable for processing from this input to other QCA circuitry. In contrast to previous concepts for bit inputs to molecular QCA, this approach requires neither special QCA cells with fixed states nor nanoelectrodes which establish fields with single-electron specificity. A brief overview of the QCA paradigm is given. Proof-of-principle simulation results are shown, demonstrating the input concept in circuits made from two-dot QCA cells. Importantly, this concept for bit inputs to molecular QCA may enable solutions to or provide insights into other challenges to the realization of molecular QCA, such as the demonstration of molecular device switching, the read-out of molecular QCA states, and the layout of molecular QCA circuits.
description: 9 pages, 15 figures. Main file is "ms.tex"
Cosmological and Environmental Influences on Hot Gas Observed in Elliptical Galaxies
Creators: name: Mathews, William G.
name: Brighenti, Fabrizio
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The variation of temperature and density in the hot, X-ray emitting gas around massive, group dominant elliptical galaxies can be understood as a combination of gas ejected from evolving galactic stars and gas that accumulates in the outer halo by secondary cosmic infall. Beginning with an overdensity perturbation in a simple flat cosmology, we can duplicate observed properties of the hot gas. At some early time we form the stellar galaxy and release supernova energy, conserving dark and baryonic matter. Using a potential appropriate to the large elliptical NGC 4472, we follow the evolution of intergalactic and interstellar gas to the present time when the computed gas density and temperature agree with X-ray observations of NGC 4472. If the hot gas and dark matter halos are subject to differential tidal truncations or mass exchanges between group members, then the correlation between $L_x/L_B$ and the relative sizes of galactic X-ray images can be generated. The physical properties of hot interstellar gas observed in bright ellipticals today are sensitive to the cosmic baryon fraction, the time of maximum star formation and the amount of ``feedback'' energy delivered to the gas by Type II supernovae at the epoch of galaxy formation.
description: 5 pages in AASTEX LaTeX including 3 figures; accepted by Astrophysical Journal Letters
The role of FOXM1 in breast cancer chemotherapy resistance
Creators: name: Khongkow, Pasarat
Publisher: name: Imperial College London
Year: 2015

description: Resistance to chemotherapeutic agents is the main obstacle to the effective breast cancer management. Therefore, it is important to elucidate the molecular mechanisms of chemoresistance and develop novel therapeutic strategies in order to overcome drug resistance. In this work, I found that FOXM1 is a critical mediator of epirubicin and paclitaxel resistance in MCF-7 breast cancer cell lines. FOXM1 expression was upregulated in both epirubicin resistant MCF-7 (MCF-7 EpiR) and paclitaxel resistant MCF-7 (MCF-7 TaxR) cells compared to sensitive MCF-7 cells. Interestingly, its depletion dramatically impaired the clonogenic survival and significantly induced cellular senescence in the resistant cells. In addition, I identified two novel downstream FOXM1 targets, NBS1 and KIF20A, involved in epirubicin and paclitaxel resistance, respectively. Firstly, I found that FOXM1 transcriptionally regulated NBS1 expression to modulate HR-mediated DSB repair and epirubicin resistance. Overexpression of FOXM1 and NBS1 lead to the enhancement of HR efficiency to eliminate epirubicin-induced DNA damage. Conversely, similar to FOXM1, depletion of NBS1 also sensitised both MCF-7 and MCF-7 EpiR cells to epirubicin by inducing cellular senescence. Secondly, I identified the mitotic kinesin KIF20A as a direct downstream target of FOXM1, participating in the mitotic spindle formation and paclitaxel resistance. Depletion of KIF20A caused mitotic spindle abnormalities, inhibition of cell growth as well as the induction of senescent cells in both MCF-7 and MCF-7 TaxR cells. Consistently, immunohistochemical analysis of breast cancer patient samples revealed that high expression levels of FOXM1, NBS1 and KIF20A are strongly correlated with poor prognosis in breast cancer, supporting a physiological role of FOXM1 and its novel targets in genotoxic drug resistance. Collectively, these findings suggests that FOXM1 and its targets, NBS1 and KIF20A, could be reliable prognostic markers for monitoring treatment efficiency as well as promising targets for therapeutic intervention to overcome epirubicin and paclitaxel resistance in breast cancer.
Ischyrolepis capensis H. P. Linder 1985
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Restionaceae
Ischyrolepis
Ischyrolepis capensis

description: Restio dichotomus Linnaeus, Systema Naturae, ed. 12, 2: 735. 1767, nom. illeg.
["Habitat ad Caput Bonae Spei."] Cent. I Pl.: 4 (1755). RCN: 7392.
Replaced synonym: Schoenus capensis L. (1755).
Lectotype (Linder in Bothalia 15: 402. 1985): Herb. Linn. No. 1164.3 (LINN).
Generitype of Restio Linnaeus, nom. rej.
Current name: Ischyrolepis capensis (L.) H.P. Linder (Restionaceae).
Note: Restio Linnaeus, nom. rej. in favour of Restio Rottböll. Restio dichotomus is a superfluous name for Schoenus capensis L.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 790, DOI: 10.5281/zenodo.291971
Guidance Document for the organisation of Proficiency Tests by NRLs for national networks, including partial outsourcing
Creators: name: LOMBARD, Bertrand
name: Mooijman, Kirsten
name: Skarin, Hanna
name: Morabito, Stefano
Publisher: name: Zenodo
Year: 2019

description: One of the duties of a National Reference Laboratory (NRL) is to organise or supervise proficiency tests (PTs) for the national network of official laboratories (OLs) it coordinates, according to Regulation (EU) 2017/625 (article 101) [1].

For different reasons (too small or too large size of the network, economic aspects, availability of human resources etc.), some NRLs currently outsource parts of these PTs.

The five EU Reference Laboratories (EURLs) on Campylobacter, Coagulase Positive Staphylococci (CPS), Listeria monocytogenes (Lm), Salmonella and Shiga-toxin-producing Escherichia coli (STEC), in agreement with their respective NRL networks, identified the need to draft a common guidance document, defining:

criteria for NRLs to organize PTs in their respective scope (see clauses 2, 4);

if relevant (see clause 3):

criteria to outsource parts of PTs organised or supervised by NRLs for national networks, including PT steps that can be outsourced or not;

criteria to select PT providers.

This document gives only guidance, since organisation of PTs at national level is a Member State’s responsibility.

This document is based upon an EURL Listeria monocytogenes document on the same topic.
Reminiscences of Lucius DuBignon Clay, Jr., 1969
Publisher: name: Columbia University
Year: 2021
Subjects: Air pilots

description: Reminiscences of his father, General Lucius D. Clay, particularly Panama experiences, 1928-1929, and interest in community projects; own career in aerospace programs, Deputy Chief of Staff, Programs and Resources, 1967-1968
TV_HORPTP 2022 cruise,Pourquoi pas ? R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2022

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens, en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, établir un protocole d'acquisition et traitement des données des transits valorisées, et faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits.Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution. le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé. les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température).Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire.Cette initiative se fait également en interaction avec le projet Seabed2030 (seabed2030.org).Contacts Benoît Loubrieu, Ifremer/ UMR GEO-OCEAN, benoit.loubrieu@ifremer.fr Javier Escartin, ENS, escartin.javier@gmail.com
EURL Lm Guidance Document on outsourcing part of proficiency testing trials organized by NRLs for national networks
Creators: name: LOMBARD, Bertrand
name: Barre, Léna
Publisher: name: Zenodo
Year: 2015

description: At the 2013 and 2014 workshops of EURL/NRLs for Listeria monocytogenes (Lm), it has been acknowledged, that, based on an enquiry conducted by EURL to NRLs in 2013, some NRLs outsource part of proficiency testing (PT) trials they organise/supervise on Lm detection/enumeration in food, for national networks of official laboratories (OLs) that they coordinate.

At these workshops, the need to draft a guidance document was agreed, listing:

criteria to outsource parts of PT trials organised or supervised by NRLs for national networks;

criteria to select PT providers, including steps of PT trials that can be outsourced or not, frequency, details on method used by participants, together with minimum values if possible.

This document could be only guidance, since organisation of PT trials at national level is a Member State’s responsibility.

It was also agreed that this guidance document would be drafted in a first step by EURL Lm, in collaboration with volunteering NRLs. In a 2nd step, other volunteering EURLs in the area of biological risks would be associated, to develop a harmonized approach.
Guidance Document for the organisation of Proficiency Tests by NRLs for national networks, including partial outsourcing
Creators: name: LOMBARD, Bertrand
name: Mooijman, Kirsten
name: Skarin, Hanna
name: Morabito, Stefano
Publisher: name: Zenodo
Year: 2019

description: One of the duties of a National Reference Laboratory (NRL) is to organise or supervise proficiency tests (PTs) for the national network of official laboratories (OLs) it coordinates, according to Regulation (EU) 2017/625 (article 101) [1].

For different reasons (too small or too large size of the network, economic aspects, availability of human resources etc.), some NRLs currently outsource parts of these PTs.

The five EU Reference Laboratories (EURLs) on Campylobacter, Coagulase Positive Staphylococci (CPS), Listeria monocytogenes (Lm), Salmonella and Shiga-toxin-producing Escherichia coli (STEC), in agreement with their respective NRL networks, identified the need to draft a common guidance document, defining:

criteria for NRLs to organize PTs in their respective scope (see clauses 2, 4);

if relevant (see clause 3):

criteria to outsource parts of PTs organised or supervised by NRLs for national networks, including PT steps that can be outsourced or not;

criteria to select PT providers.

This document gives only guidance, since organisation of PTs at national level is a Member State’s responsibility.This document is based upon an EURL Listeria monocytogenes document on the same topic.
ALFA: First Operational Experience of the MPE/MPIA Laser Guide Star System for Adaptive Optics
Creators: name: Davies, R. I.
name: Hackenberg, W.
name: Ott, T.
name: Eckart, A.
name: Holstenberg, H. -C.
name: Rabien, S.
name: Quirrenbach, A.
name: Kasper, M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The sodium laser guide star adaptive optics system ALFA has been constructed at the Calar Alto 3.5-m telescope. Following the first detection of the laser beacon on the wavefront sensor in 1997 the system is now being optimized for best performance. In this contribution we discuss the current status of the launch beam and the planned improvements and upgrades. We report on the performance level achieved when it is used with the adaptive optics system, and relate various aspects of our experience during operation of the system. We have begun to produce scientific results and mention two of these.
description: 9 pages, 6 figures, LaTeX (spie.sty). SPIE conf proc 3353, Adaptive Optical System Technologies, March 1998
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00238
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00238, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
On MEF2C regulation of the chondrocyte phenotype
Creators: name: Lazzarano, Stefano
Publisher: name: Imperial College London
Year: 2014

description: Articular cartilage is a highly specialised tissue composed of a mechanically competent matrix and a single cell population– the chondrocytes. The maintaining of a specialised phenotype requires the integration of intracellular signalling, that in response to appropriate extracellular stimuli, results in expression of cell-specific genes. Previous work in our laboratory has identified hypoxia as one such key stimulus, which through HIF-2􀁄, enhances expression of cartilage master regulator SOX9 and its matrix-encoding target genes (COL2A1, AGC and COL9A1). MEF2C transcription factor is known to be involved in muscle and cardiovascular development; however, recently it has been shown to play a key role in chondrocyte hypertrophy co-ordinately with SOX9. In a previous microarray analysis, we found that MEF2C was upregulated during hypoxia-induced re-dedifferentiation of human articular chondrocytes (HACs); interestingly where its suggested genetic target - COL10A1 - was barely detectable. In this research we therefore investigated a possible new and unknown function of MEF2C transcription factor as a potential genetic regulator of the permanent articular chondrocyte phenotype. In this study, MEF2C protein was detected with a nuclear localisation in chondrocytes in situ in intact healthy human articular cartilage. Experiments in isolated HACs revealed that, at both gene and protein levels, hypoxia enhances MEF2C expression in a HIF-2 and SOX9 dependent fashion. Subsequently, depletion experiments of MEF2C indicated that it is required for SOX9 gene expression both in normoxia and hypoxia. Our results, therefore suggest a mutual positive regulation between MEF2C and SOX9 transcription factors in articular cartilage. Thus, based on our studies a new and critical function for transcription factor MEF2C in HACs has been identified, where it helps promote expression of the differentiated chondrocyte phenotype through mutual regulation with SOX9. These findings give important new insights into our understanding of the transcription factor networks that regulate expression of the articular chondrocyte phenotype.
Entanglement-breaking channels with general outcome operator algebras
Creators: name: Kuramochi, Yui
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: A unit-preserving and completely positive linear map, or a channel, $Λ\colon \mathcal{A} \to \mathcal{A}_{\mathrm{in}}$ between $C^\ast$-algebras $\mathcal{A}$ and $\mathcal{A}_{\mathrm{in}}$ is called entanglement-breaking (EB) if $ω\circ( Λ\otimes \mathrm{id}_{\mathcal{B}} ) $ is a separable state for any $C^\ast$-algebra $\mathcal{B}$ and any state $ω$ on the injective $C^\ast$-tensor product $\mathcal{A}_{\mathrm{in}} \otimes \mathcal{B} .$ In this paper, we establish the equivalence of the following conditions for a channel $Λ$ with a quantum input space and with a general outcome $C^\ast$-algebra, generalizing known results in finite dimensions: (i) $Λ$ is EB; (ii) $Λ$ has a measurement-prepare form (Holevo form); (iii) $n$ copies of $Λ$ are compatible for all $2 \leq n < \infty ;$ (iv) countably infinite copies of $Λ$ are compatible. By using this equivalence, we also show that the set of randomization-equivalence classes of normal EB channels with a fixed input von Neumann algebra is upper and lower Dedekind-closed, i.e. the supremum or infimum of any randomization-increasing or decreasing net of EB channels is also EB. As an example, we construct an injective normal EB channel with an arbitrary outcome operator algebra $\mathcal{M}$ acting on an infinite-dimensional separable Hilbert space by using the coherent states and the Bargmann measure.
description: 25 pages. New sections have been added
TV_LPTSIN 2022 cruise,Marion Dufresne R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2022

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique »L¿acquisition de données bathymétriques sur ce transit est à l¿initiative d¿un groupe de géologues et géophysiciens , en concertation avec la Flotte Océanographique Française.L¿objectif global de cette initiative est de généraliser l¿acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d¿acquisition ettraitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits.Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d¿une centaine de mètres).L¿acquisition de données se fait dans un mode contraint : - la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution.- le sondeur multifaisceaux est placé dans un mode automatique. L¿acquisition n¿est pas nécessairement suivie en continu par un opérateur spécialisé.- les profils de célérité utilisés pour l¿acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l¿acquisition (de type sondes de température).Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer.L¿acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d¿autorisation n¿est nécessaire.Cette initiative se fait également en interaction avec le projet Seabed2030 (seabed2030.org).ContactsBenoît Loubrieu, Ifremer/ UMR GEO-OCEAN, benoit.loubrieu@ifremer.frJavier Escartin, ENS, escartin.javier@gmail.com
Reminiscences of Ludwig Teller, 1962
Publisher: name: Columbia University
Year: 2021
Subjects: Politicians
Lawyers
Labor laws and legislation
Industrial relations

description: Childhood and education; New York University Law School; labor relations, Navy, 1943-1945; labor relations specialist, law practice; drafting Taft-Hartley Act; New York, N.Y. West Side politics: Amsterdam Democratic Club, relationship of clubhouse to New York County Committee, role and function of district leader, reform movement; State Assemblyman; Congressman. Impressions of Carmine De Sapio
TV_BESMIN 2023 cruise,Thalassa R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2023

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens , en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : - la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution. - le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé. - les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température). Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030 (seabed2030.org).
Record breaking statistics near second order phase transitions
Creators: name: Kundu, Mily
name: Mukherjee, Sudip
name: Biswas, Soumyajyoti
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: When a quantity reaches a value higher (or lower) than its value at any time before, it is said to have made a record. We numerically study the statistical properties of records in the time series of order parameters in different models near their critical points. Specifically, we choose transversely driven Edwards-Wilkinson model for interface depinning in (1+1) dimensions and the Ising model in two dimensions, as paradigmatic and simple examples of non-equilibrium and equilibrium critical behaviors respectively. The total number of record breaking events in the time series of the order parameters of the models show maxima when the system is near criticality. The number of record breaking events and associated quantities, such as the distribution of the waiting time between successive record events, show power law scaling near the critical point. The exponent values are specific to the universality classes of the respective models. Such behaviors near criticality can be used as a precursor to imminent criticality i.e. abrupt and catastrophic changes in the system. Due to the extreme nature of the records, its measurements are relatively free of detection errors and thus provide a clear signal regarding the state of the system in which they are measured.
description: 8 pages, 9 figures
Cover crops improve soil structure and change organic carbon distribution in macroaggregate fractions
Creators: name: Gentsch, Norman
name: Riechers, Florin Laura
name: Boy, Jens
name: Schweneker, Dörte
name: Feuerstein, Ulf
name: Heuermann, Diana
name: Guggenberger, Georg
Publisher: name: Göttingen : Copernicus Publ.
Year: 2024
Subjects: subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: Soil structure is sensitive to intensive soil management. It can be ameliorated by a reduction in soil cultivation and stimulation of plant and microbial mediators for aggregate formation, with the latter being a prerequisite and measure for soil quality. Cover crops (CCs) are part of an integrated approach to stabilize or improve soil quality. Thereby, the incorporation of diverse CC mixtures is hypothesized to increase the positive effects of CC applications. This study entailed an investigation of the legacy effect of CCs on soil aggregates after three crop rotations in the second main crop (winter wheat) after the last CC treatment. Four CCs (mustard, phacelia, clover, and oat) cultivated in pure stands and with a fallow treatment were compared to a mixture of the four CC species (Mix4) and a highly diverse 12-plant-species mixture (Mix12) in a long-term field experiment in Germany. The organic carbon (OC) distribution within macroaggregate fractions (16-8, 8-4, 4-2, 2-1, and <1mm) and their aggregate stability were measured by dry- and wet-sieving methods, and the mean weight diameter (MWD) was calculated from water-stable aggregates. The results showed that, compared to the fallow, all CCs increased the MWD between 10% and 19% in soil under the following main crop. The average MWD increase over the fallow was slightly higher for CC mixtures (16%) than for single CCs (12%). Most of the OC (67.9% on average) was stored in the <1mm aggregate fraction, highest in the topsoil and decreasing with soil depth. The intermediate fractions (8-4mm, 4-2mm, 2-1mm) stored 8.5%, 10.5%, and 11.0% of the total OC, while 2.1% was stored in the 16-8mm fraction. Higher MWD improvement at the 20-30cm depth also indicates additional benefits from a reduction in the cultivation depth. Structural equation modelling (SEM) suggests that single CCs were more likely to increase OC storage in small macroaggregates <1mm, while CC mixtures were more likely to increase OC in the largest fraction (8-16mm). Different individual CC species or mixtures exhibited varying involvement in the formation of different aggregate fractions. We provide evidence that litter quality, root morphology, and rhizosphere input, which affect microbial mediators of aggregate formation, might be the main reasons for the observed differences between CC treatments. Cover crops are valuable multifunctional tools for sustainable soil management. Here, we showed that they contribute to structure amelioration in arable soils. Increasing the functional diversity of plant species in CC mixtures could be a strategy to further enhance the positive effects of CCs in agroecosystems.
Bifurcation in Rotational Spectra of Nonlinear AB$_2$ Molecules
Creators: name: Kozin, I. N.
name: Pavlichenkov, I. M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A classical microscopic theory of rovibrational motion at high angular momenta in symmetrical non-linear molecules AB$_2$ is derived within the framework of small oscillations near the stationary states of a rotating molecule. The full-dimensional analysis including stretching vibrations has confirmed the existence of the bifurcation predicted previously by means of the rigid-bender model. The formation of fourfold energy clusters has already been experimentally verified for H$_2$Se and it has been demonstrated in fully-dimensional quantum mechanical calculations using the MORBID computer program. We show in the present work that apart from the level clustering, the bifurcation produces physically important effects including molecular symmetry-breaking and a transition from the normal mode to the local mode limit for the stretching vibrations due to rovibrational interaction. The application of the present theory with realistic molecular potentials to the H$_2$Te, H$_2$Se and H$_2$S hydrides results in predictions of the bifurcation points very close to those calculated previously. However for the lighter H$_2$O molecule we find that the bifurcation occurs at higher values of the total angular momentum than obtained in previous estimations. The present work shows it to be very unlikely that the bifurcation in H$_2$O will lead to clustering of energy levels. This result is in agreement with recent variational calculations.
description: latex, 19 pages including 2 figures provided as *.uu file
Elegia juncea Linnaeus 1771
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Restionaceae
Elegia
Elegia juncea

description: Restio elegia Linnaeus, Systema Vegetabilium, ed. 13: 738. 1774, nom. illeg.
["Habitat ad Cap. b. spei. Koenig."] Mant. Pl. Alt.: 297 (1771). RCN: 7396.
Replaced synonym: Elegia juncea L. (1771).
Neotype (Linder in Bothalia 15: 424. 1985): Herb. Linn. No. 1164a.4 (LINN).
Current name: Elegia juncea L. (Restionaceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 790, DOI: 10.5281/zenodo.291971
Visual-Inertial Object Detection and Mapping
Creators: name: Fei, Xiaohan
name: Soatto, Stefano
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: We present a method to populate an unknown environment with models of previously seen objects, placed in a Euclidean reference frame that is inferred causally and on-line using monocular video along with inertial sensors. The system we implement returns a sparse point cloud for the regions of the scene that are visible but not recognized as a previously seen object, and a detailed object model and its pose in the Euclidean frame otherwise. The system includes bottom-up and top-down components, whereby deep networks trained for detection provide likelihood scores for object hypotheses provided by a nonlinear filter, whose state serves as memory. Additional networks provide likelihood scores for edges, which complements detection networks trained to be invariant to small deformations. We test our algorithm on existing datasets, and also introduce the VISMA dataset, that provides ground truth pose, point-cloud map, and object models, along with time-stamped inertial measurements.
Studies of ion channel mechanisms in pancreatic ductal adenocarcinoma (PDAC)
Creators: name: Bonito, Benedetta
Publisher: name: Imperial College London
Year: 2016

description: Pancreatic Ductal Adenocarcinoma (PDAC) is the most common type of pancreatic neoplasia, accounting for more than 90% of all pancreatic cancer cases. Despite improvements in early diagnosis and treatment, the 5-year survival rate has remained unvaried for many decades. The aim of this PhD project was to elucidate the roles of two specific ion channels in the pathophysiology of PDAC: voltage-gated sodium channel (VGSC) and the Ca2+- activated K+ channel KCa3.1. Human pancreatic cell lines of different metastatic potential were used: HPDE (human pancreatic ductal epithelial) cells, Panc-1, MiaPaCa-2, BxPC-3 and Capan-1 cells. VGSCs, typically expressed in neuronal, ‘excitable’ cells, were also found earlier to be functional in several different carcinomas, where they are linked to promotion of the metastatic potential. KCa3.1, which serves a diversity of physiological roles such as cell-volume regulation in erythrocytes and migration in macrophages and microglia, may also promote tumour invasiveness as shown for some tumours including gliomas end endometrial cancer. Initially, the expression of different VGSC subtypes (Nav1.1 - Nav1.7) was screened in PDAC cell lines and abundant levels of mRNA and protein were found. However, whole-cell patch clamp recordings detected a small inward current (~ 30 pA/pF) only in the 10% of MiaPaCa-2 cells, one of the most aggressive cell lines available. Based on the PCR, western blot and patch clamp results obtained, we hypothesized that epidermal growth factor receptor (EGFR) might suppress VGSC expression to protect the Na+/H+ exchanger (NHE1), which has been proposed to serve a ’backbone’ function in driving PDAC metastasis by promoting extracellular acidosis. Indeed, when the EGFR pathway was blocked pharmacologically (by AG1478 10 μM) an increased inward Na+ current was detected by whole-cell patch clamp. Further experiments showed that a combination treatment of AG1478 and TTX (tetrodotoxin) and cariporide (an NHE1 inhibitor) and TTX could reduce cell migration further than treatments alone. This suggested that inhibition of the EGF-EGFR signalling cascade increases VGSC activity and this promoted metastatic cell behaviours. We also found that KCa3.1 channel was overexpressed at mRNA, protein and functional levels in PDAC compared to control cells . We demonstrated both pharmacologically and by gene - silencing approach that this channel regulated the migration and proliferation of MiaPaCa-2 cell line, revealing its potential as another target for therapy, as it has been also suggested in other carcinomas (i.e. endometrial cancer). These results are discussed in their respective chapters. The Thesis ends with a General Discussion chapter, where recent findings on the pathophysiology of PDAC are further highlighted in relation to the findings of the thesis.
TV_PTPBES 2023 cruise,Pourquoi pas ? R/V
Creators: name: Benoit, LOUBRIEU
name: Javier, ESCARTIN
Publisher: name: Sismer
Year: 2023

description: Initiative « Valorisation bathymétrique des transits de la flotte océanographique » L'acquisition de données bathymétriques sur ce transit est à l'initiative d'un groupe de géologues et géophysiciens , en concertation avec la Flotte Océanographique Française. L'objectif global de cette initiative est de généraliser l'acquisition de données de sondeurs multifaisceaux sur les transits des navires de la flotte, en vue de a) compléter les couvertures bathymétriques existantes à moyenne et haute résolution et contribuer à la cartographie bathymétrique globale des océans, b) établir un protocole d'acquisition et traitement des données des transits valorisées, et c) faciliter les travaux de recherche à travers le partage publique des données acquises lors de ces transits. Les données sont destinées à un usage de cartographie moyenne résolution (modèle numérique de terrain au pas de grille d'une centaine de mètres). L'acquisition de données se fait dans un mode contraint : - la vitesse du navire est celle fixée par le transit, sans ajustement vis-à-vis de la qualité des données ou leur résolution. - le sondeur multifaisceaux est placé dans un mode automatique. L'acquisition n'est pas nécessairement suivie en continu par un opérateur spécialisé. - les profils de célérité utilisés pour l'acquisition des données et le calcul des sondes sont établis à partir de tables globales, sans mesure in-situ de température et salinité lors de l'acquisition (de type sondes de température). Les données sont pré-traitées et validées et sont destinées à être mise à disposition à court terme dans la base de données des navires océanographiques Sismer. L'acquisition est limitée aux eaux internationales, pour lesquelles aucune demande d'autorisation n'est nécessaire. Cette initiative se fait également en interaction avec le projet Seabed2030 (seabed2030.org).
Breaking flavor democracy with symmetric perturbations
Creators: name: Ghosh, Tathagata
name: Liao, Jiajun
name: Marfatia, Danny
name: Yanagida, Tsutomu T.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Flavor democracy broken in the fermion mass matrix by means of small perturbations can give rise to hierarchical fermion masses. We study the breaking of the $S^L_3 \times S^R_3$ symmetry associated with democratic mass matrices to a smaller exchange symmetry $S^L_2 \times S^R_2$ in the charged lepton, up and down quark sectors. An additional breaking of the $S^L_2 \times S^R_2$ symmetry is necessary for the down quark mass matrix, which yields arbitrary perturbations in that sector. On the other hand, we require the neutrino mass matrix to be diagonal at the leading order, with the perturbations left arbitrary due to the absence of any guiding symmetry. We show that the interplay between these two kinds of perturbations reproduces the quark and lepton mass and mixing observables for either hierarchy of neutrino masses.
description: 13 pages, 2 figures, 2 tables. Version to appear in PLB
Protein separation using surfactant precipitation
Creators: name: Faizal Wong, Fadzlie Wong
Publisher: name: Imperial College London
Year: 2015

description: Protein precipitation using a variety of surfactants has been shown to have considerable potential as a protein separation technique, and considerable work on using anionic surfactants has been carried out by previous researchers. However, anionic surfactants are only suitable for high pI proteins due to concerns about protein stability. Therefore, the first aim of this work was to develop a surfactant precipitation method for low pI proteins based on using cationic surfactants. The effect of important parameters such as the molar ratio of TOMAC to protein (Rp), and pH on the precipitation of bovine serum albumin, α-amylase, and trypsin inhibitor were examined. Recovery of the TOMAC-protein complex by solvent extraction and counter-ionic surfactant (AOT) was also studied. Varied results were obtained for the three proteins, and were correlated with protein properties, and it was found that the protein’s hydrophobicity and molecular weight were the best predictors for precipitation efficiency and recovery. The second aim of this research was to examine the feasibility of using a biocompatible surfactant – methyl ester sulphonate (MES) as a precipitating-ligand for target proteins in this surfactant precipitation technique. This work was a major breakthrough in the application of a new generation of ‘green’ surfactants for protein extraction. Lysozyme was used as a model protein in a single component system, and the influence of Rp, and pH were examined. Similarly, the recovery of the precipitate using solvent extraction and a counter-ionic surfactant, AOT, was studied. The performance of MES in precipitation was compared to a conventional surfactant, AOT, and it was found that their performance was comparable. This further highlighted its potential to be used as precipitant in protein purification. The third aim of this work was to apply the surfactant precipitation method to the purification of a target protein from a real industrial sample. Bacteriocin produced by Pediococcus acidilactici Kp10 was chosen as a target protein for this purpose. With a concentration of 11.56 mM of AOT (pH 4), precipitate recovery by acetone (0.99 mM NaCl), and a final recovery phase of 20 mM PBS (pH 7), about 86.3% of overall activity recovery, and a purification factor of about 53.8 was obtained. Further, this separation technique was shown to be better than reverse micellar extraction, and aqueous two-phase extraction in terms of performance. Hence, the surfactant precipitation technique was proven to be an effective and a viable separation method.
Role of Goldenberry (Fruits with Husk) Extract in Ameliorating the Architecture and Osmotic Fragility of Red Blood Cells in Obese Rats
Creators: name: Abdelmottaleb Moussa, Sherif A.
name: Aziz, Samir W.
name: Abd El-Latif, Noha A.
name: Bashandy, Samir A. E.
name: Elbaset, Marawan A.
name: Afifi, Sherif M.
name: Esatbeyoglu, Tuba
name: El Toumy, Sayed A.
name: Salib, Josline Y.
Publisher: name: New York [u.a.] : Hindawi
Year: 2023
Subjects: subject: Animals
subject: Blood Viscosity
subject: Erythrocytes
subject: Fruit
subject: Osmotic Fragility
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Goldenberry (GB) is a promising fruit that can be a constituent in many possible nourishments. No notifications were obtained regarding the impact of exposure to goldenberry extract in the viewpoint of blood rheological properties as well as erythrocyte osmotic fragility of red blood cells (RBCs) in obese rats. A substantial reduction in plasma triglyceride, total cholesterol, and LDL, with a considerable increment in HDL levels relative to the obese group (p≤0.05), was observed in rats receiving low and high doses of GB, accompanied by restoration of SOD activity and GSH levels. Rheological parameters of rats' blood have been studied over a wide range of shear rates (225-1875 s-1). A significant decrease in blood viscosity in rats who received low and high doses of GB extract was compatible with every shear rate compared to the control group. The shear stress values of the obese rats reduced appreciably (p≤0.05) in all values of shear rate (from 75 to 500 s-1) proportional to the control group, while in the groups that received low and high doses of GB extract, shear stress was restored to the control values. Finally, administration of GB extract significantly decreased yield stress and indices of whole blood aggregation, with an extremely substantial increment in flow rate, in rats given low or high doses of GB compared to obese ones. The result also showed a decrease in both the average raised osmotic fragility and the hemolysis rate in rats after supplementation with low and high doses of GB extract.