cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses
Creators: name: Cohen, Alexandra R.
name: Kharazia, Viktor
name: Yang, Fu Chia
name: Sheng, Morgan
name: Weinberg, Richard J.
name: Naisbitt, Scott
name: Hsueh, Yi Ping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: CASK, the rat homolog of a gene (LIN-2) required for vulval differentiation in Caenorhabditis elegans, is expressed in mammalian brain, but its function in neurons is unknown. CASK is distributed in a punctate somatodendritic pattern in neurons. By immunogold EM, CASK protein is concentrated in synapses, but is also present at nonsynaptic membranes and in intracellular compartments. This immunolocalization is consistent with biochemical studies showing the presence of CASK in soluble and synaptosomal membrane fractions and its enrichment in postsynaptic density fractions of rat brain. By yeast two-hybrid screening, a specific interaction was identified between the PDZ domain of CASK and the COOH terminal tail of syndecan-2, a cell surface heparan sulfate proteoglycan (HSPG). The interaction was confirmed by coimmunoprecipitation from heterologous cells. In brain, syndecan-2 localizes specifically at synaptic junctions where it shows overlapping distribution with CASK, consistent with an interaction between these proteins in synapses. Cell surface HSPGs can bind to extracellular matrix proteins, and are required for the action of various heparin-binding polypeptide growth/differentiation factors. The synaptic localization of CASK and syndecan suggests a potential role for these proteins in adhesion and signaling at neuronal synapses.
Additional file 1 of Safety and efficacy of double-balloon catheter for cervical ripening: a Bayesian network meta-analysis of randomized controlled trials
Creators: name: Zhao, Ge
name: Song, Guang
name: Liu, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: TableS1. PRISMA Network Meta-analysis Checklist. TableS2. Strategy of this meta-analysis. TableS3. Head-to-head comparisons of cesarean delivery rate. Table S4. Head-to-head comparisons oftime from intervention-to-birth. TableS5. Head-to-head comparisons of achieving vaginal delivery within 24 hours.Table S6. Head-to-head comparisonsof Bishop score increment. Table S7. Head-to-head comparisons of uterine hyperstimulation with fetal heart ratechanges. Table S8. Head-to-headcomparisons of oxytocin augmentation. TableS9. Head-to-head comparisons of instrumental delivery. Table S10. Head-to-head comparisons of meconium-stained amnioticfluid. Table S11. Head-to-headcomparisons of chorioamnionitis. TableS12. Head-to-head comparisons of postpartum hemorrhage. Table S13. Head-to-head comparisons ofApgar score <7 in 5 min. Table S14.Head-to-head comparisons of Apgar score <7 in 1 min. Figure S15. Inconsistency test of Apgar score <7 in 1 min. Table S16. Head-to-head comparisons ofarterial pH. Table S17. Assessmentof publication bias for network meta-analysis. Figure S1. Risk of bias summary. Figure S2. Risk of bias graph. FigureS2. Risk of bias graph. Figure S4. Inconsistency test of cesarean delivery rate. Figure S5. Inconsistency test of Time from intervention-to-birth. Figure S6. Inconsistency test ofachieving vaginal delivery within 24 hours. Figure S7. Inconsistency test of Bishop score increment. Figure S8. Inconsistency test ofuterine hyperstimulation with fetal heart rate changes. Figure S9. Inconsistency test of oxytocin augmentation. Figure S10. Inconsistency test ofinstrumental delivery. Figure S11. Inconsistency test of meconium-stained amniotic fluid. Figure S12. Inconsistency test of chorioamnionitis. Figure S13. Inconsistency test ofpostpartum hemorrhage. Figure S14. Inconsistency test of Apgar score <7 in 5 min. Figure S15. Inconsistency test of Apgar score <7 in 1 min. Figure S16. Inconsistency test ofneonatal intensive care unit admission. Figure S17. Funnel plot of primary outcomes. Figure S18. Funnel plot of secondary outcomes.
Supplementary text from Seasonal migration of marsupial megafauna in Pleistocene Sahul (Australia–New Guinea)
Creators: name: Price, Gilbert J.
name: Ferguson, Kyle J.
name: Webb, Gregory E.
name: Feng, Yue-Xing
name: Pennilyn Higgins
name: Nguyen, Ai Duc
name: Zhao, Jian-Xin
name: Joannes-Boyau, Renaud
name: Louys, Julien
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Supplementary text concerning geochronology and geochemical interpretations
Solyanik estimates in ergodic theory
Creators: name: Hagelstein, Paul A.
name: Parissis, Ioannis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: Let $U_1, \ldots, U_n$ be a collection of commuting measure preserving transformations on a probability space $(Ω, Σ, μ)$. Associated with these measure preserving transformations is the ergodic strong maximal operator $\mathsf M ^\ast _{\mathsf S}$ given by \[ \mathsf M ^\ast _{\mathsf S} f(ω) := \sup_{0 \in R \subset \mathbb{R}^n}\frac{1}{\#(R \cap \mathbb{Z}^n)}\sum_{(j_1, \ldots, j_n) \in R\cap \mathbb{Z}^n}\big|f(U_1^{j_1}\cdots U_n^{j_n}ω)\big|, \] where the supremum is taken over all open rectangles in $\mathbb{R}^n$ containing the origin whose sides are parallel to the coordinate axes. For $0 < α< 1$ we define the sharp Tauberian constant of $\mathsf M ^\ast _{\mathsf S}$ with respect to $α$ by \[ \mathsf C ^\ast _{\mathsf S} (α) := \sup_{\substack{E \subset Ω\\ μ(E) > 0}}\frac{1}{μ(E)}μ(\{ω\in Ω: \mathsf M ^\ast _{\mathsf S} χ_E (ω) > α\}). \] Motivated by previous work of A. A. Solyanik and the authors regarding Solyanik estimates for the geometric strong maximal operator in harmonic analysis, we show that the Solyanik estimate \[ \lim_{α\rightarrow 1}\mathsf C ^\ast _{\mathsf S}(α) = 1 \] holds, and that in particular we have \[\mathsf C ^\ast _{\mathsf S}(α) - 1 \lesssim_n (1 - \frac{1}α)^{1/n}\] provided that $α$ is sufficiently close to $1$. Solyanik estimates for centered and uncentered ergodic Hardy-Littlewood maximal operators associated with $U_1, \ldots, U_n$ are shown to hold as well. Further directions for research in the field of ergodic Solyanik estimates are also discussed.
Nothing Like the Movies by Lynn Painter on Iphone New Format
Creators: name: Lopez
Publisher: name: Zenodo
Year: 2024

description: Nothing Like the Movies by Lynn Painter

 

 

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Nothing Like the Movies

Lynn Painter

Page: 368

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ISBN: 9781665971829

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This Barnes & Noble Exclusive Edition includes a unique, alternate cover, and bonus content of a deleted chapter that didn't make it into the final text! In this highly anticipated sequel to the New York Times bestselling Better than the Movies, Wes and Liz struggle to balance their feelings for each other with the growing pains of being a college student. For a few beautiful months, Wes had his dream girl: strong-willed girl-next-door Liz. But right as the two were about to set off to UCLA to start their freshman year together, tragedy struck. Wes was left dealing with the fallout, which ultimately meant losing Liz in the process. Flash forward months and months later and Wes and Liz find themselves in college, together. In a healthier place now, Wes knows he broke Liz’s heart when he ended things, but he is determined to make her fall back in love with him. Wes knows Liz better than anyone, and he has a foolproof plan to win her back with the rom-com worthy big gestures she loves. Only...Liz will have none of it. Wes has to scheme like a rom-com hero to figure out how to see her. Even worse, Liz has a new friend...a guy friend. Still, Wes won’t give up, adapting his clever plans and going hard to get Liz’s attention and win back her affection. But after his best efforts get him nowhere, Wes is left wondering if their relationship is really over for good.
Revised extinctions and radii for 1.5 million stars observed by APOGEE, GALAH, and RAVE
Creators: name: Yu, Jie
name: Khanna, Shourya
name: Themessl, Nathalie
name: Hekker, Saskia
name: Dréau, Guillaume
name: Gizon, Laurent
name: Bi, Shaolan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Asteroseismology has become widely accepted as a benchmark for accurate and precise fundamental stellar properties. It can therefore be used to validate and calibrate stellar parameters derived from other approaches. Meanwhile, one can leverage large-volume surveys in photometry, spectroscopy, and astrometry to infer stellar parameters over a wide range of evolutionary stages, independently of asteroseismology. Our pipeline, SEDEX, compares the spectral energy distribution predicted by the MARCS and BOSZ model spectra with 32 photometric bandpasses, combining data from 9 major, large-volume photometric surveys. We restrict the analysis to targets with available spectroscopy from the APOGEE, GALAH, and RAVE surveys to lift the temperature-extinction degeneracy. The cross-survey atmospheric parameter and uncertainty estimates are homogenized with artificial neural networks. Validation of our results with CHARA interferometry, HST CALSPEC spectrophotometry, and asteroseismology, shows that we achieve high precision and accuracy. We present a catalog of improved interstellar extinction ($σ_{A_V} \simeq$ 0.14 mag) and stellar radii ($σ_R/R \simeq$ 7.4\%) for $\sim$1.5 million stars in the low- to high-extinction ($A_V \lesssim 6 $ mag) fields observed by the spectroscopic surveys. We derive global extinctions for 184 Gaia DR2 open clusters, and confirm the differential extinction in NGC 6791 and NGC 6819 that have been subject to extensive asteroseismic analysis. Furthermore, we report 36,854 double-lined spectroscopic main-sequence binary candidates. This catalog will be valuable for providing constraints on detailed modelling of stars and for constructing 3D dust maps of the Kepler field, the TESS CVZs, and the PLATO long duration observation fields.
description: The paper has been accepted by ApJS and is in the press. The updated version includes the following changes: (1) Calibrating atmospheric parameters from APOGEE DR17, GALAH DR3, and RAVE DR6 on consistent scales. (2) Revised estimates for extinction and radius are now available for download at https://www.dropbox.com/scl/fo/oh5c65jql7pkwz92rc2ay/h?dl=0&rlkey=hskthdyqxm89jqy3k71e1lnvm
(3089) Percy Stewart Wilthew
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hydrostatic Pressure Shows That Lamellipodial Motility in Ascaris Sperm Requires Membrane-associated Major Sperm Protein Filament Nucleation and Elongation
Creators: name: Roberts, Thomas M.
name: Stewart, Murray
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Sperm from nematodes use a major sperm protein (MSP) cytoskeleton in place of an actin cytoskeleton to drive their ameboid locomotion. Motility is coupled to the assembly of MSP fibers near the leading edge of the pseudopod plasma membrane. This unique motility system has been reconstituted in vitro in cell-free extracts of sperm from Ascaris suum: inside-out vesicles derived from the plasma membrane trigger assembly of meshworks of MSP filaments, called fibers, that push the vesicle forward as they grow (Italiano, J.E., Jr., T.M. Roberts, M. Stewart, and C.A. Fontana. 1996. Cell. 84:105–114). We used changes in hydrostatic pressure within a microscope optical chamber to investigate the mechanism of assembly of the motile apparatus. The effects of pressure on the MSP cytoskeleton in vivo and in vitro were similar: pressures >50 atm slowed and >300 atm stopped fiber growth. We focused on the in vitro system to show that filament assembly occurs in the immediate vicinity of the vesicle. At 300 atm, fibers were stable, but vesicles often detached from the ends of fibers. When the pressure was dropped, normal fiber growth occurred from detached vesicles but the ends of fibers without vesicles did not grow. Below 300 atm, pressure modulates both the number of filaments assembled at the vesicle (proportional to fiber optical density and filament nucleation rate), and their rate of assembly (proportional to the rates of fiber growth and filament elongation). Thus, fiber growth is not simply because of the addition of subunits onto the ends of existing filaments, but rather is regulated by pressure-sensitive factors at or near the vesicle surface. Once a filament is incorporated into a fiber, its rates of addition and loss of subunits are very slow and disassembly occurs by pathways distinct from assembly. The effects of pressure on fiber assembly are sensitive to dilution of the extract but largely independent of MSP concentration, indicating that a cytosolic component other than MSP is required for vesicle-association filament nucleation and elongation. Based on these data we present a model for the mechanism of locomotion-associated MSP polymerization the principles of which may apply generally to the way cells assemble filaments locally to drive protrusion of the leading edge.
Additional file 2 of Short term exposure to air pollution and mortality in the US: a double negative control analysis
Creators: name: Liu, Rongqi Abbie
name: Wei, Yaguang
name: Qiu, Xinye
name: Kosheleva, Anna
name: Schwartz, Joel D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 2: Supplementary Table 1. Incremental effect modification.
Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension
Creators: name: Chen, Rey Huei
name: Waters, Jennifer C.
name: Murray, Andrew W.
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: A single unattached kinetochore can delay anaphase onset in mitotic tissue culture cells (Rieder, C.L., A. Schultz, R. Cole, G. Sluder. 1994. J. Cell Biol. 127:1301–1310). Kinetochores in vertebrate cells contain multiple binding sites, and tension is generated at kinetochores after attachment to the plus ends of spindle microtubules. Checkpoint component Mad2 localizes selectively to unattached kinetochores (Chen, R.-H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Science. 274:242–246; Li, Y., and R. Benezra. Science. 274: 246–248) and disappears from kinetochores by late metaphase, when chromosomes are properly attached to the spindle. Here we show that Mad2 is lost from PtK1 cell kinetochores as they accumulate microtubules and re-binds previously attached kinetochores after microtubules are depolymerized with nocodazole. We also show that when kinetochore microtubules in metaphase cells are stabilized with taxol, tension at kinetochores is lost. The phosphoepitope 3f3/2, which has been shown to become dephosphorylated in response to tension at the kinetochore (Nicklas, R.B., S.C. Ward, and G.J. Gorbsky. 1995. J. Cell Biol. 130:929–939), is phosphorylated on all 22 kinetochores after tension is reduced with taxol. In contrast, Mad2 only localized to an average of 2.6 out of the 22 kinetochores in taxol-treated PtK1 cells. Therefore, loss of tension at kinetochores occupied by microtubules is insufficient to induce Mad2 to accumulate on kinetochores, whereas unattached kinetochores consistently bind Mad2. We also found that microinjecting antibodies against Mad2 caused cells arrested with taxol to exit mitosis after ∼12 min, while uninjected cells remained in mitosis for at least 6 h, demonstrating that Mad2 is necessary for maintenance of the taxol-induced mitotic arrest. We conclude that kinetochore microtubule attachment stops the Mad2 interactions at kinetochores which are important for inhibiting anaphase onset.
CAZADORES DE SOMBRAS 6: CIUDAD DEL FUEGO CELESTIAL CASSANDRA CLARE ePub gratis
Creators: name: Cook
Publisher: name: Zenodo
Year: 2024

description: CAZADORES DE SOMBRAS 6: CIUDAD DEL FUEGO CELESTIAL de CASSANDRA CLARE

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CAZADORES DE SOMBRAS 6: CIUDAD DEL FUEGO CELESTIAL

CASSANDRA CLARE

Número de páginas: 672

Idioma: CASTELLANO

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ISBN: 9788408131939

Editorial: PLANETA

Año de edición: 2014

 

 

 

 

 

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¡El esperadísimo desenlace de la saga Cazadores de Sombras!ERCHOMAI, HABÍA DICHO SEBASTIANVoy de camino.La oscuridad ha regresado al Mundo de las Sombras. Mientras su mundo se desmorona alrededor, Clary, Jace, Simon y sus amigos deben unirse para luchar contra el mayor enemigo al que se han enfrentado nunca los nefilim: el hermano de Clary. No hay nada en el mundo que pueda derrotarle; ¿deberán ir a otro mundo para tener una posibilidad? Se perderán vidas, se sacrificarán amores y el mundo entero cambiará en el sexto volumen de la serie Cazadores de Sombras.
Quasinormal modes of Schwarzschild black holes on the real axis
Creators: name: Kyutoku, Koutarou
name: Motohashi, Hayato
name: Tanaka, Takahiro
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the scattering of gravitational waves by a Schwarzschild black hole and its perturbed siblings to investigate influences of proposed spectral instability of quasinormal modes on the ringdown signal. Our results indicate that information of dominant ringdown signals, which are ascribed to the fundamental (i.e., least damping) quasinormal mode of unperturbed Schwarzschild black holes, is imprinted in the phase shift defined from the transmission amplitude (1/A_{in} in our notation). This approximately parallels the fact that the resonance of quantum systems is imprinted in the phase shift of the S-matrix. The phase shift around the oscillation frequency of the fundamental mode is modified only perturbatively even if the quasinormal-mode spectrum is destabilized by a perturbative bump at a distant location, signifying the stability of the ringdown signal. At the same time, the phase shift at low frequencies is modulated substantially reflecting the late-time excitation of echo signals associated with the quasinormal-mode spectrum after destabilization.
description: 16 pages, 8 figures
Pauli-Villars Regularization in nonperturbative Hamiltonian approach on the Light Front
Creators: name: Malyshev, M. Yu.
name: Paston, S. A.
name: Prokhvatilov, E. V.
name: Zubov, R. A.
name: Franke, V. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The advantage of Pauli-Villars regularization in quantum field theory quantized on the light front is explained. Simple examples of scalar $λφ^4$ field theory and Yukawa-type model are used. We give also an example of nonperturbative calculation in the theory with Pauli-Villars fields, using for that a model of anharmonic oscillator modified by inclusion of ghost variables playing the role similar to Pauli-Villars fields.
description: LaTeX, 10 pages, 2 figures. Article will be published in AIP Conference Proceedings, the final publication will be available at http://scitation.aip.org/content/aip/proceeding/aipcp
Selecting Sagittarius: Identification and Chemical Characterization of the Sagittarius Stream
Creators: name: Hyde, E. A.
name: Keller, S.
name: Zucker, D. B.
name: Ibata, R.
name: Siebert, A.
name: Lewis, G. F.
name: Penarrubia, J.
name: Irwin, M.
name: Gilmore, G.
name: Lane, R. R.
name: Koch, A.
name: Conn, A. R.
name: Diakogiannis, F. I.
name: Martell, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Wrapping around the Milky Way, the Sagittarius stream is the dominant substructure in the halo. Our statistical selection method has allowed us to identify 106 highly likely members of the Sagittarius stream. Spectroscopic analysis of metallicity and kinematics of all members provides us with a new mapping of the Sagittarius stream. We find correspondence between the velocity distribution of stream stars and those computed for a triaxial model of the Milky Way dark matter halo. The Sagittarius trailing arm exhibits a metallicity gradient, ranging from $-0.59$ dex to $-0.97$ dex over 142$^{\circ}$. This is consistent with the scenario of tidal disruption from a progenitor dwarf galaxy that possessed an internal metallicity gradient. We note high metallicity dispersion in the leading arm, causing a lack of detectable gradient and possibly indicating orbital phase mixing. We additionally report on a potential detection of the Sextans dwarf spheroidal in our data.
Lithurgus atratiformis Cockerell
Creators: name: Gonzalez, Victor H.
name: Engel, Michael S.
name: Griswold, Terry L.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Megachilidae
Lithurgus
Lithurgus atratiformis

description: Lithurgus atratiformis Cockerell
(Figs. 20–22)
 Lithurgus atratiformis Cockerell, 1905: 295. Holotype: NHML No. 17.a.2098; ♀, NW coast of Australia.
 DIAGNOSIS: Among Australian Lithurgus, L. atratiformis is most similar to L. atratus Smith in the black or dark brown sternal scopa, distal terga with dark setae (Fig. 20), and mesoscutum with strong rugulae (Fig. 21). The female can be distinguished from that species primarily by its larger body size (head width 4.5 mm vs. 4.2 mm) and broader facial prominence (Fig. 22, about two-thirds length of lower interorbital distance vs. about half length of lower interorbital distance).
 COMMENTS: Cockerell (1905) did not state the number of specimens on which he based the description of L. atratiformis but the female specimen deposited in the NHML has a label in Cockerell’s handwriting that reads “type”. Cockerell usually labeled one specimen as “type” and the others in the type series as “cotypes”, corresponding to the modern holotype and paratype concepts. A designation of lectotype is therefore not necessary as the NHML specimen is assuredly a holotype.
 As indicated by Michener (1965), L. atratiformis is morphologically very similar to L. atratus, L. scabrosus (Smith), and L. collaris Smith and they may be conspecific. Except for subtle differences in body size, we did not find consistent morphological differences between the male specimens associated with females that matched the type of L. atratiformis and those males associated with females that matched the type of L. atratus. For this reason, the males of both species are not separated in the key.
description: Published as part of Gonzalez, Victor H., Engel, Michael S. & Griswold, Terry L., 2013, The lithurgine bees of Australia (Hymenoptera: Megachilidae), with a note on Megachile rotundipennis, pp. 1-19 in Journal of Melittology 2013 (11) on pages 10-11, DOI: 10.17161/jom.v0i11.4520, http://zenodo.org/record/13737296
(3090) Edwin Augustus Wilthew
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bulk evidence of anisotropic $s$-wave pairing with no sign change in the kagome superconductor CsV$_3$Sb$_5$
Creators: name: Roppongi, M.
name: Ishihara, K.
name: Tanaka, Y.
name: Ogawa, K.
name: Okada, K.
name: Liu, S.
name: Mukasa, K.
name: Mizukami, Y.
name: Uwatoko, Y.
name: Grasset, R.
name: Konczykowski, M.
name: Ortiz, B. R.
name: Wilson, S. D.
name: Hashimoto, K.
name: Shibauchi, T.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The recently discovered kagome superconductors $A$V$_3$Sb$_5$ ($A$ = K, Rb, Cs) possess a unique band structure with van Hove singularities and Dirac dispersions, in which unusual charge-density-wave (CDW) orders with time-reversal and rotational symmetry breaking have been reported. One of the most crucial unresolved issues is identifying the symmetry of the superconductivity that develops inside the CDW phase. Theory predicts a variety of unconventional superconducting symmetries, including exotic states with chiral and topological properties accompanied by a sign-changing superconducting gap. Experimentally, however, the phase information on the superconducting gap in $A$V$_3$Sb$_5$ is still lacking. Here we report the electron irradiation effects in CsV$_3$Sb$_5$ using introduced impurities as a phase-sensitive probe of superconductivity. Our magnetic penetration depth measurements reveal that with increasing impurities, a highly anisotropic fully-gapped state changes gradually to an isotropic full-gap state without passing through a nodal state. Furthermore, transport measurements under high pressure show that the double superconducting dome in the pressure-temperature phase diagram survives against sufficient impurities. These results are strong bulk evidence that CsV$_3$Sb$_5$ is a non-chiral, anisotropic $s$-wave superconductor with no sign change both at ambient and high pressure, which provides a clue to understanding the relationship between CDW and superconductivity in kagome superconductors.
description: 22 pages, 4 figures
Polymerization of Purified Yeast Septins: Evidence That Organized Filament Arrays May Not Be Required for Septin Function
Creators: name: Pringle, John R.
name: Field, Christine
name: Mitchison, Timothy J.
name: Mann, Matthias
name: Frazier, Jennifer A.
name: Longtine, Mark S.
name: Wong, Mei Lie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The septins are a family of proteins required for cytokinesis in a number of eukaryotic cell types. In budding yeast, these proteins are thought to be the structural components of a filament system present at the mother–bud neck, called the neck filaments. In this study, we report the isolation of a protein complex containing the yeast septins Cdc3p, Cdc10p, Cdc11p, and Cdc12p that is capable of forming long filaments in vitro. To investigate the relationship between these filaments and the neck filaments, we purified septin complexes from cells deleted for CDC10 or CDC11. These complexes were not capable of the polymerization exhibited by wild-type preparations, and analysis of the neck region by electron microscopy revealed that the cdc10Δ and cdc11Δ cells did not contain detectable neck filaments. These results strengthen the hypothesis that the septins are the major structural components of the neck filaments. Surprisingly, we found that septin dependent processes like cytokinesis and the localization of Bud4p to the neck still occurred in cdc10Δ cells. This suggests that the septins may be able to function in the absence of normal polymerization and the formation of a higher order filament structure.
Additional file 3 of Short term exposure to air pollution and mortality in the US: a double negative control analysis
Creators: name: Liu, Rongqi Abbie
name: Wei, Yaguang
name: Qiu, Xinye
name: Kosheleva, Anna
name: Schwartz, Joel D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 3: Supplementary Table 2. Single lag models for temperature and absolute humidity.
Role of the Yeast Gin4p Protein Kinase in Septin Assembly and the Relationship between Septin Assembly and Septin Function
Creators: name: Fares, Hanna
name: Pringle, John R.
name: Longtine, Mark S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: To identify septin-interacting proteins in Saccharomyces cerevisiae, we screened for mutations that are synthetically lethal with a cdc12 septin mutation. One of the genes identified was GIN4, which encodes a protein kinase related to Hsl1p/Nik1p and Ycl024Wp in S. cerevisiae and to Nim1p/Cdr1p and Cdr2p in Schizosaccharomyces pombe. The Gin4p kinase domain displayed a two-hybrid interaction with the COOH-terminal portion of the Cdc3p septin, and Gin4p colocalized with the septins at the mother–bud neck. This localization depended on the septins and on the COOH-terminal (nonkinase) region of Gin4p, and overproduction of this COOH-terminal region led to a loss of septin organization and associated morphogenetic defects. We detected no effect of deleting YCL024W, either alone or in combination with deletion of GIN4. Deletion of GIN4 was not lethal but led to a striking reorganization of the septins accompanied by morphogenetic abnormalities and a defect in cell separation; however, remarkably, cytokinesis appeared to occur efficiently. Two other proteins that localize to the neck in a septin-dependent manner showed similar reorganizations and also appeared to remain largely functional. The septin organization observed in gin4Δ vegetative cells resembles that seen normally in cells responding to mating pheromone, and no Gin4p was detected in association with the septins in such cells. The organization of the septins observed in gin4Δ cells and in cells responding to pheromone appears to support some aspects of the model for septin organization suggested previously by Field et al. (Field, C.M., O. Al-Awar, J. Rosenblatt, M.L. Wong, B. Alberts, and T.J. Mitchison. 1996. J. Cell Biol. 133:605–616).
The chemical enrichment of the Milky Way disk evaluated using conditional abundances
Creators: name: Ratcliffe, Bridget
name: Ness, Melissa
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Chemical abundances of stars in the Milky Way disk are empirical tracers of its enrichment history. However, they capture joint-information that is valuable to disentangle. In this work, we seek to quantify how individual abundances evolve across the present-day radius of the disk, at fixed supernovae contribution ([Fe/H], [Mg/Fe]). We use 18,135 APOGEE DR17 red clump stars and 7,943 GALAH DR3 main sequence stars to compare the abundance distributions conditioned on ([Fe/H], [Mg/Fe]) across $3-13$ kpc and $6.5-9.5$ kpc, respectively. In total we examine 15 elements: C, N, Al, K (light), O, Si, S, Ca, ($α$), Mn, Ni, Cr, Cu, (iron-peak) Ce, Ba (s-process) and Eu (r-process). We find that the conditional neutron capture and light elements most significantly trace variations in the disk's enrichment history, with absolute conditional radial gradients $\leq 0.03$ dex/kpc. The other elements studied have absolute conditional gradients $\lesssim 0.01$ dex/kpc. We uncover structured conditional abundance variations as a function of [Fe/H] for the low-$α$, but not the high-$α$ sequence. The average scatter between the mean conditional abundances at different radii is $σ_\text{intrinsic} \approx$ 0.02 dex (with Ce, Eu, Ba $σ_\text{intrinsic} >$ 0.05 dex). These results serve as a measure of the magnitude via which different elements trace Galactic radial enrichment history once fiducial supernovae correlations are accounted for. Furthermore, we uncover subtle systematic variations in all moments of the conditional abundance distributions that will presumably constrain chemical evolution models of the Galaxy.
description: Submitted to ApJ
Cusps and Exotic Charmonia
Creators: name: Swanson, E. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A simple, causal, and analytic model of final state rescattering is used to describe all available data on the exotic resonances $Z_c(3900)$ and $Z_c(4025)$. The model provides a compelling and accurate representation of experiment with no need for poles in the scattering matrix.
description: 6 pages, 6 figures
God of Ruin: Special Edition Print by Rina Kent on Iphone New Format
Creators: name: Rogers
Publisher: name: Zenodo
Year: 2024

description: God of Ruin: Special Edition Print by Rina Kent

 

 

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God of Ruin: Special Edition Print

Rina Kent

Page: 422

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ISBN: 9781685452131

Publisher: Blackthorn Books

 

Epub ebooks download rapidshare God of Ruin: Special Edition Print by Rina Kent (English literature)

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NOTE: This is the special edition print of X. To find the ebook and audiobook, please look for the main edition. I'm out for revenge. After careful planning, I gave the man who messed with my family a taste of his own medicine. I thought it'd end there. It didn't. Landon King is a genius artist, a posh rich boy, and my worst nightmare. He's decided that I'm the new addition to his chess game. Too bad for him, I'm no pawn. If he hits, I hit back, twice as hard and with the same hostility. He says he'll ruin me. Little does he know that ruination goes both ways.
A Role for P21-Activated Kinase in Endothelial Cell Migration
Creators: name: Bokoch, Gary M.
name: Schwartz, Martin Alexander
name: Daniels, R. Hugh
name: Otey, Carol
name: Kiosses, William B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The serine/threonine p21-activated kinase (PAK) is an effector for Rac and Cdc42, but its role in regulating cytoskeletal organization has been controversial. To address this issue, we investigated the role of PAK in migration of microvascular endothelial cells. We found that a dominant negative (DN) mutant of PAK significantly inhibited cell migration and in-creased stress fibers and focal adhesions. The DN effect mapped to the most NH2-terminal proline-rich SH3-binding sequence. Observation of a green fluorescent protein-tagged α-actinin construct in living cells revealed that the DN construct had no effect on membrane ruffling, but dramatically inhibited stress fiber and focal contact motility and turnover. Constitutively active PAK inhibited migration equally well and also increased stress fibers and focal adhesions, but had a somewhat weaker effect on their dynamics. In contrast to their similar effects on motility, DN PAK decreased cell contractility, whereas active PAK increased contractility. Active PAK also increased myosin light chain (MLC) phosphorylation, as indicated by staining with an antibody to phosphorylated MLC, whereas DN PAK had little effect, despite the increase in actin stress fibers. These results demonstrate that although PAK is not required for extension of lamellipodia, it has substantial effects on cell adhesion and contraction. These data suggest a model in which PAK plays a role coordinating the formation of new adhesions at the leading edge with contraction and detachment at the trailing edge.
An Amplitude-Based Implementation of the Unit Step Function on a Quantum Computer
Creators: name: Koppe, Jonas
name: Wolf, Mark-Oliver
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Modelling non-linear activation functions on quantum computers is vital for quantum neurons employed in fully quantum neural networks, however, remains a challenging task. We introduce an amplitude-based implementation for approximating non-linearity in the form of the unit step function on a quantum computer. Our approach expands upon repeat-until-success protocols, suggesting a modification that requires a single measurement only. We describe two distinct circuit types which receive their input either directly from a classical computer, or as a quantum state when embedded in a more advanced quantum algorithm. All quantum circuits are theoretically evaluated using numerical simulation and executed on Noisy Intermediate-Scale Quantum hardware. We demonstrate that reliable experimental data with high precision can be obtained from our quantum circuits involving up to 8 qubits, and up to 25 CX-gate applications, enabled by state-of-the-art hardware-optimization techniques and measurement error mitigation.
description: 11 pages, 9 figures, 1 table
Additional file 4 of Short term exposure to air pollution and mortality in the US: a double negative control analysis
Creators: name: Liu, Rongqi Abbie
name: Wei, Yaguang
name: Qiu, Xinye
name: Kosheleva, Anna
name: Schwartz, Joel D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 4: Supplementary Table 3. Effects of Negative Exposure Controls.
(3091) Annie Eleanor Turnbull
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Alternative Splicing Regulates the Subcellular Localization of a-Kinase Anchoring Protein 18 Isoforms
Creators: name: Fraser, Iain D.C.
name: Trotter, Kevin W.
name: Stutts, M. Jackson
name: Milgram, Sharon L.
name: Scott, Gregory K.
name: Scott, John D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The cAMP-dependent protein kinase (PKA) is localized to specific subcellular compartments by association with A-kinase anchoring proteins (AKAPs). AKAPs are a family of functionally related proteins that bind the regulatory (R) subunit of PKA with high affinity and target the kinase to specific subcellular organelles. Recently, AKAP18, a low molecular weight plasma membrane AKAP that facilitates PKA-mediated phosphorylation of the L-type Ca2+ channel, was cloned. We now report the cloning of two additional isoforms of AKAP18, which we have designated AKAP18β and AKAP18γ, that arise from alternative mRNA splicing. The AKAP18 isoforms share a common R subunit binding site, but have distinct targeting domains. The original AKAP18 (renamed AKAP18α) and AKAP18β target the plasma membrane when expressed in HEK-293 cells, while AKAP18γ is cytosolic. When expressed in epithelial cells, AKAP18α is targeted to lateral membranes, whereas AKAP18β is accumulated at the apical membrane. A 23-amino acid insert, following the plasma membrane targeting domain, facilitates the association of AKAP18β with the apical membrane. The data suggest that AKAP18 isoforms are differentially targeted to modulate distinct intracellular signaling events. Furthermore, the data suggest that plasma membrane AKAPs may be targeted to subdomains of the cell surface, adding additional specificity in intracellular signaling.
Additional file 1 of Short term exposure to air pollution and mortality in the US: a double negative control analysis
Creators: name: Liu, Rongqi Abbie
name: Wei, Yaguang
name: Qiu, Xinye
name: Kosheleva, Anna
name: Schwartz, Joel D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1: Figure E1. Percent increase in cause-specific mortality for PM2.5, O3, and NO2 using the single-lag model.
Effects of spike-triggered negative feedback on receptive-field properties
Creators: name: Urdapilleta, Eugenio
name: Samengo, Inés
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Sensory neurons are often described in terms of a receptive field, that is, a linear kernel through which stimuli are filtered before they are further processed. If information transmission is assumed to proceed in a feedforward cascade, the receptive field may be interpreted as the external stimulus' profile maximizing neuronal output. The nervous system, however, contains many feedback loops, and sensory neurons filter more currents than the ones representing the transduced external stimulus. Some of the additional currents are generated by the output activity of the neuron itself, and therefore constitute feedback signals. By means of a time-frequency analysis of the input/output transformation, here we show how feedback modifies the receptive field. The model is applicable to various types of feedback processes, from spike triggered intrinsic conductances to inhibitory synaptic inputs from nearby neurons. We distinguish between the intrinsic receptive field (filtering all input currents) and the effective receptive field (filtering only external stimuli). Whereas the intrinsic receptive field summarizes the biophysical properties of the neuron associated to subthreshold integration and spike generation, only the effective receptive field can be interpreted as the external stimulus' profile maximizing neuronal output. We demonstrate that spike-triggered feedback shifts low-pass filtering towards band-pass processing, transforming integrator neurons into resonators. For strong feedback, a sharp resonance in the spectral neuronal selectivity may appear. Our results provide a unified framework to interpret a collection of previous experimental studies where specific feedback mechanisms were shown to modify the filtering properties of neurons.
description: 46 pages, 10 figures. Preprint accepted for publication in J. Comput. Neurosci
A comprehensive continuum theory of structured liquids
Creators: name: Blossey, Ralf
name: Podgornik, Rudolf
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We develop a comprehensive continuum model capable of treating both electrostatic and structural interactions in liquid dielectrics. Starting from a two-order parameter description in terms of charge density and polarization, we derive a field-theoretic model generalizing previous theories. Our theory explicitly includes electrostatic and structural interactions in the bulk of the liquid and allows for polarization charges within a Drude model. In particular, we develop a detailed description of the boundary conditions which include the charge regulation mechanism and surface polarization. The general features for solving the saddle-point equations of our model are elucidated and future applications to predict and validate experimental results are outlined.
description: 19 pages; accepted for publication in J. Phys. A
Axo-Glial Interactions Regulate the Localization of Axonal Paranodal Proteins
Creators: name: Dupree, Jeffrey L.
name: Girault, Jean Antoine
name: Popko, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Mice incapable of synthesizing the abundant galactolipids of myelin exhibit disrupted paranodal axo-glial interactions in the central and peripheral nervous systems. Using these mutants, we have analyzed the role that axo-glial interactions play in the establishment of axonal protein distribution in the region of the node of Ranvier. Whereas the clustering of the nodal proteins, sodium channels, ankyrinG, and neurofascin was only slightly affected, the distribution of potassium channels and paranodin, proteins that are normally concentrated in the regions juxtaposed to the node, was dramatically altered. The potassium channels, which are normally concentrated in the paranode/juxtaparanode, were not restricted to this region but were detected throughout the internode in the galactolipid-defi- cient mice. Paranodin/contactin-associated protein (Caspr), a paranodal protein that is a potential neuronal mediator of axon-myelin binding, was not concentrated in the paranodal regions but was diffusely distributed along the internodal regions. Collectively, these findings suggest that the myelin galactolipids are essential for the proper formation of axo-glial interactions and demonstrate that a disruption in these interactions results in profound abnormalities in the molecular organization of the paranodal axolemma.
Supplementary figures from Determinants of spring migration departure decision in a bat.
Creators: name: Dechmann, Dina K. N.
name: M. Wikelski
name: D. Ellis-Soto
name: K. Safi
name: M. Teague O'Mara
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Density distributions of weather data, correlation between body condition at capture and time until departure and year-round wind data.