cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of the speed of sound at large-N
Creators: name: Zavala, Ivonne
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The implications of a smaller than unity speed of sound of the scalar perturbations during cosmic inflation is studied in terms of a model independent large-$N$ approach. We show that the $(n_s, r)$ plane is non-trivially degenerated when the effects of a different than one speed of sound $c_s$ are taken into account. We also discuss the degeneracies due to $c_s$ in the running of the spectral index, $α_s$. We use the bounds on $c_s$ to constrain such degeneracies.
description: 4 figures, 5 pages. References added. Typos corrected. Improved discussion. Version to appear in PRD
Perceived stress, mental health symptoms, and deleterious behaviors during the transition to college
Creators: name: Mazzolenis, M. Emilia
name: Pepper, Mollie A.
name: Perreira, Krista M.
name: Fruehwirth, Jane Cooley
Publisher: name: Public Library of Science
Year: 2023

description: Background This study examined associations between different sources of chronic perceived stress and deleterious behaviors (eating disorder symptoms, insufficient sleep, and insufficient vigorous physical activity) among first-year college students. Methods The study used data on 885 first-year students (ages 18–20) at a large public university in North Carolina. The prevalence of deleterious behaviors was evaluated. Associations were estimated between different sources of chronic perceived stress (academic, future, peers, friendships, romantic, appearance, health, chronic illness, financial, work, family) and health behaviors after controlling for psychosocial supports and demographics. Moderating effects of gender and moderate-severe anxiety/depression symptoms were also tested. Results 19% of first-year student reported symptoms of eating disorders, 42% insufficient sleep, and 43% insufficient vigorous physical activity. Perceived chronic stress increased the odds of reporting these deleterious behaviors. These effects were not moderated by gender or moderate-severe anxiety/depression symptoms. Appearance- and health-related stress were associated with eating disorder symptoms; health- and romantic-related stress were associated with insufficient sleep; and health-related stress was associated with insufficient vigorous physical activity. Limitations Outcomes were survey-based. The study was based on cross-sectional data from a single university, so the direction of causality cannot be determined, and more work needs to be done to determine whether this would extend to other populations.
title: Methods of symmetry reduction and their application.
Creators: name: Priestley, Thomas James
Publisher: name: University of Kent
Year: 2022

description: In this thesis methods of symmetry reduction are applied to several physically relevant partial differential equations. The first chapter serves to acquaint the reader with the symmetry methods used in this thesis. In particular the classical method of Lie, an extension of it by Bluman and Cole [1969], known as the nonclassical method, and the direct method of Clarkson and Kruskal [1989] are described. Other known extensions of these methods are outlined, including potential symmetries, introduced by Bluman, Kumei and Reid [1988]. Also described are the tools used in practice to perform the calculations. The remainder of the thesis is split into two parts. In Part One the classical and nonclassical methods are applied to three classes of scalar equation: a generalised Boussinesq equation, a class of third order equations and a class of fourth order equations. Many symmetry reductions and exact solutions are found. In Part Two each of the classical, nonclassical and direct methods are applied to various systems of partial differential equations. These include shallow water wave systems, six representations of the Boussinesq equation and a reaction-diffusion equation written as a system. In Chapters Five and Six both the actual application of these methods and their results is compared and contrasted. In such applications, remarkable phenomena can occur, in both the nonclassical and direct methods. In particular it is shown that the application of the direct method to systems of equations is not as conceptually straightforward as previously thought, and a way of completing the calculations of the nonclassical method via hodograph transformations is introduced. In Chapter Seven it is shown how more symmetry reductions may be found via nonclassical potential symmetries, which are a new extension on the idea of potential symmetries. In the final chapter the relationship between the nonclassical and direct methods is investigated in the light of the previous chapters. The thesis is concluded with some general remarks on its findings and on possible future work.
Kirche der Sünder - Kirche der Ungläubigen?
Creators: name: Jaschke, Hans-Jochen
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 3 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 3
Consistency of Perfect Fluidity and Jet Quenching in semi-Quark-Gluon Monopole Plasmas
Creators: name: Xu, Jiechen
name: Liao, Jinfeng
name: Gyulassy, Miklos
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We utilize a new framework, CUJET3.0, to deduce the energy and temperature dependence of jet transport parameter, $\hat{q}(E>10\; {\rm GeV},T)$, from a combined analysis of available data on nuclear modification factor and azimuthal asymmetries from RHIC/BNL and LHC/CERN on high energy nuclear collisions. Extending a previous perturbative-QCD based jet energy loss model (known as CUJET2.0) with (2+1)D viscous hydrodynamic bulk evolution, this new framework includes three novel features of nonperturbative physics origin: (1) the Polyakov loop suppression of color-electric scattering (aka "semi-QGP" of Pisarski et al) and (2) the enhancement of jet scattering due to emergent magnetic monopoles near $T_c$ (aka "magnetic scenario" of Liao and Shuryak) and (3) thermodynamic properties constrained by lattice QCD data. CUJET3.0 reduces to v2.0 at high temperatures $T > 400$ MeV, but greatly enhances $\hat{q}$ near the QCD deconfinement transition temperature range. This enhancement accounts well for the observed elliptic harmonics of jets with $p_T>10$ GeV. Extrapolating our data-constrained $\hat{q}$ down to thermal energy scales, $E \sim 2$ GeV, we find for the first time a remarkable consistency between high energy jet quenching and bulk perfect fluidity with $η/s\sim T^3/\hat{q} \sim 0.1$ near $T_c$.
description: 6 pages, 4 figures; v2: major text revisions, title and abstract modified, typos corrected, references added
Why we aren't always convinced by facts
Creators: name: Smeets, Ionica
Publisher: name: Zenodo
Year: 2023
Subjects: science communication
Leiden University

description: Dies lecture by Ionica Smeets on the 448th Dies Natalis of Leiden University. About what is science communication, values in science, valuing science communication, the science in science communication and the question: what is good science communication?
Inositol polyphosphate derivative inhibits Na + transport and improves fluid dynamics in cystic fibrosis airway epithelia
Creators: name: McNamara, Sharon
name: Traynor-Kaplan, Alexis E.
name: Widdicombe, Jonathan
name: Dinkel, Carlo
name: Schultz, Carsten
name: Pennington, Carey
name: Gabriel, Sherif
name: Caldwell, Ray
name: Rossi, Michael W.
name: Moody, Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Amiloride-sensitive, epithelial Na+ channel (ENaC)-mediated, active absorption of Na+ is elevated in the airway epithelium of cystic fibrosis (CF) patients, resulting in excess fluid removal from the airway lumen. This excess fluid/volume absorption corresponds to CF transmembrane regulator-linked defects in ENaC regulation, resulting in the reduced mucociliary clearance found in CF airways. Herein we show that INO-4995, a synthetic analog of the intracellular signaling molecule, D-myo-inositol 3,4,5,6-tetrakisphosphate, inhibits Na+ and fluid absorption across CF airway epithelia, thus alleviating this critical pathology. This conclusion was based on electrophysiological studies, fluid absorption, and 22Na+ flux measurements in CF airway epithelia, contrasted with normal epithelia, and on electrophysiological studies in Madin-Darby canine kidney cells and 3T3 cells overexpressing ENaC. The effects of INO-4995 were long-lasting, dose-dependent, and more pronounced in epithelia from CF patients vs. controls. These findings support preclinical development of INO-4995 for CF treatment and demonstrate for the first time the therapeutic potential of inositol polyphosphate derivatives.
Additional file 1: of A DELPHI study on aspects of study design to overcome knowledge gaps on the burden of disease caused by serogroup B invasive meningococcal disease
Creators: name: Marten, Ole
name: Koerber, Florian
name: Bloom, David
name: Bullinger, Monika
name: Buysse, Corinne
name: Christensen, Hannah
name: Wals, Philippe
name: Dohna-Schwake, Christian
name: Henneke, Philipp
name: Kirchner, Markus
name: Knuf, Markus
name: Lawrenz, Burkhard
name: Monteiro, Andrea
name: Sevilla, Joseph
name: Velde, Nicolas
name: Welte, Robert
name: Wright, Claire
name: Greiner, Wolfgang
Publisher: name: Figshare
Year: 2019
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: The first-round DELPHI questionnaire. (DOCX 225 kb)
Apostila do módulo 2 do Curso On-line de Iniciação em Pesquisa Científica: Princípios Éticos em Pesquisa
Creators: name: Geroto, Isadora
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 461004
subject: Information governance, policy and ethics

description: Esta é a apostila do Módulo 2, Princípios Éticos em Pesquisa, do Curso On-line de Iniciação em Pesquisa Científica promovido pelo SIBi UFSCar e CRBU Unifesp.
Joint statistics of quantum transport in chaotic cavities
Creators: name: Cunden, Fabio Deelan
name: Facchi, Paolo
name: Vivo, Pierpaolo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the joint statistics of conductance $G$ and shot noise $P$ in chaotic cavities supporting a large number $N$ of open electronic channels in the two attached leads. We determine the full phase diagram in the $(G,P)$ plane, employing a Coulomb gas technique on the joint density of transmission eigenvalues, as dictated by Random Matrix Theory. We find that in the region of typical fluctuations, conductance and shot noise are uncorrelated and jointly Gaussian, and away from it they fluctuate according to a different joint rate function in each phase of the $(G,P)$ plane. Different functional forms of the rate function in different regions emerge as a direct consequence of third order phase transitions in the associated Coulomb gas problem.
description: 6 pages, 1 figure
Loss of mXinα, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects
Creators: name: Gustafson-Wagner, Elisabeth A.
name: Yang, Baoli
name: Williamson, Roger A.
name: Sinn, Haley W.
name: Reiter, Rebecca S.
name: Chen, Yen-Lin
name: Wang, Da-Zhi
name: Lin, Jim J.-C.
name: Lin, Cheng-I.
name: Chen, Ju
name: Lin, Jenny L.-C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The intercalated disk protein Xin was originally discovered in chicken striated muscle and implicated in cardiac morphogenesis. In the mouse, there are two homologous genes, mXinα and mXinβ. The human homolog of mXinα, Cmya1, maps to chromosomal region 3p21.2–21.3, near a dilated cardiomyopathy with conduction defect-2 locus. Here we report that mXinα-null mouse hearts are hypertrophied and exhibit fibrosis, indicative of cardiomyopathy. A significant upregulation of mXinβ likely provides partial compensation and accounts for the viability of the mXinα-null mice. Ultrastructural studies of mXinα-null mouse hearts reveal intercalated disk disruption and myofilament disarray. In mXinα-null mice, there is a significant decrease in the expression level of p120-catenin, β-catenin, N-cadherin, and desmoplakin, which could compromise the integrity of the intercalated disks and functionally weaken adhesion, leading to cardiac defects. Additionally, altered localization and decreased expression of connexin 43 are observed in the mXinα-null mouse heart, which, together with previously observed abnormal electrophysiological properties of mXinα-deficient mouse ventricular myocytes, could potentially lead to conduction defects. Indeed, ECG recordings on isolated, perfused hearts (Langendorff preparations) show a significantly prolonged QT interval in mXinα-deficient hearts. Thus mXinα functions in regulating the hypertrophic response and maintaining the structural integrity of the intercalated disk in normal mice, likely through its association with adherens junctional components and actin cytoskeleton. The mXinα-knockout mouse line provides a novel model of cardiac hypertrophy and cardiomyopathy with conduction defects.
Nanosemiconductores coloidales para celdas solares, fotocatálisis y otras aplicaciones
Creators: name: Bernechea, María
Publisher: name: Zenodo
Year: 2021

description: Presentation at 1- XVIII Ciclo de conferencias Facultad de Ciencias "Divulgación por Diversión" 2- Curso Introducción á Nanociencia e a Nanotecnoloxía 21/22 A Coruña, 29 October 2021
Identification of neural circuits involved in female genital responses in the rat: a dual virus and anterograde tracing study
Creators: name: Murphy, A. Z.
name: Marson, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The spinal and peripheral innervation of the clitoris and vagina are fairly well understood. However, little is known regarding supraspinal control of these pelvic structures. The multisynaptic tracer pseudorabies virus (PRV) was used to map the brain neurons that innervate the clitoris and vagina. In order to delineate forebrain input onto PRV labeled cells, the anterograde tracer biotinylated dextran amine (BDA) was injected into the medial preoptic nucleus (MPO), ventromedial nucleus of the hypothalamus (VMN) or the midbrain periaqueductal gray (PAG) 10 days prior to viral injections. These brain regions have been intimately linked to various aspects of female reproductive behavior. Four days after viral injections, into the vagina and clitoris PRV labeled cells were observed in the paraventricular nucleus, Barrington’s nucleus, the A5 region, and the nucleus paragigantocellularis. At 5 days post-viral administration, additional PRV labeled cells were observed within the preoptic region, VMN, PAG and lateral hypothalamus. Anterograde labeling from the MPO terminated among PRV positive cells primarily within the dorsal paraventricular nucleus of the hypothalamus (PVN), ventrolateral VMN (VMNvl), caudal PAG and nucleus paragigantocellularis (nPGi). Anterograde labeling from the VMN terminated among PRV positive cells in the MPO and lateral/ventrolateral PAG. Anterograde labeling from the PAG terminated among PRV positive cells in the PVN, ventral hypothalamus and nPGi. Transynaptically labeled cells in the lateral hypothalamus, Barrington's nucleus and ventromedial medulla received innervation from all three sources. These studies, together, identify several CNS sites participating in the neural control of female sexual responses. They also provide the first data demonstrating a link between the MPO, VMNvl and PAG and CNS regions innervating the clitoris and vagina, providing support that these areas play a major role in female genital responses.
Additional file 1: of EcRBPome: a comprehensive database of all known E. coli RNA-binding proteins
Creators: name: Pritha Ghosh
name: Adwait Joshi
name: Guita, Niang
name: Offmann, Bernard
name: R. Sowdhamini
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Methods. Further details of the genome-wide survey and cross-genome comparison methods have been presented in this file (DOCX 21 kb)
Aktualität des Themas »Kirche aus Juden und Heiden«
Creators: name: Balthasar, Hans Urs Von
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 3 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 3
Stata code: Clinical severity of SARS-CoV-2 Omicron BA.4 and BA.5 lineages compared to BA.1 and Delta in South Africa
Creators: name: Wolter, Nicole
Publisher: name: Zenodo
Year: 2022
Subjects: SARS-CoV-2
Omicron
Severity
South Africa

description: Stata code used to generate and analyse the dataset supporting findings in the manuscript authored by Wolter et al "Clinical severity of SARS-CoV-2 Omicron BA.4 and BA.5 lineages compared to BA.1 and Delta in South Africa"
Perioperative Management of Patients Undergoing Total Pancreatectomy with/without Islet Cell Autotransplantation: A Single Center Experience
Creators: name: Madduri, Supradeep S.
name: Agala, Chris B.
name: McEwan, Sasha
name: Weng, Chengyu
name: Desai, Chirag S.
name: Reid, Trista D.
Publisher: name: MDPI
Year: 2023

description: Total pancreatectomy (TP) and islet cell autotransplantation (IAT) are complex operations that require intensive postoperative monitoring with standardized protocols. There are few studies detailing immediate perioperative management. The purpose of this study was to describe the perioperative management of post-pancreatectomy patients in the first week following surgery to guide clinicians in addressing salient points from different organ systems. This is a retrospective cohort review of prospectively collected data from September 2017 to September 2022 at a single institution, including patients 16 years and older who underwent TP or TPIAT for chronic pancreatitis. Patients were maintained on a heparin drip (TPIAT), insulin drip, and ketamine infusion. Primary outcomes were complications in the first 5 days following surgery and ICU length of stay (LOS). Secondary outcomes included overall LOS and mortality. Of 31 patients, 26 underwent TPIAT, and 5 underwent TP. Median ICU LOS was five days (IQR 4–6). The most common immediate postoperative complications were reintubation [n = 5 (16%)] and bleeding [n = 2 (6%)]. Median insulin drip use was 70 h (IQR 20–124). There was no mortality. Patients were extubated quickly and progressed well on the protocol. Immediate postoperative complications were generally minor and without long-term effects.
Generalization of Clustering Agreements and Distances for Overlapping Clusters and Network Communities
Creators: name: Rabbany, Reihaneh
name: Zaïane, Osmar R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: A measure of distance between two clusterings has important applications, including clustering validation and ensemble clustering. Generally, such distance measure provides navigation through the space of possible clusterings. Mostly used in cluster validation, a normalized clustering distance, a.k.a. agreement measure, compares a given clustering result against the ground-truth clustering. Clustering agreement measures are often classified into two families of pair-counting and information theoretic measures, with the widely-used representatives of Adjusted Rand Index (ARI) and Normalized Mutual Information (NMI), respectively. This paper sheds light on the relation between these two families through a generalization. It further presents an alternative algebraic formulation for these agreement measures which incorporates an intuitive clustering distance, which is defined based on the analogous between cluster overlaps and co-memberships of nodes in clusters. Unlike the original measures, it is easily extendable for different cases, including overlapping clusters and clusters of inter-related data for complex networks. These two extensions are, in particular, important in the context of finding clusters in social and information networks, a.k.a communities.
Additional file 3: of EcRBPome: a comprehensive database of all known E. coli RNA-binding proteins
Creators: name: Pritha Ghosh
name: Adwait Joshi
name: Guita, Niang
name: Offmann, Bernard
name: R. Sowdhamini
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Table S1v List of hypothetical proteins from E. coli proteomes that were annotated as RNA binding proteins through detection of RNA binding domain (DOCX 49 kb)
Variational superposed Gaussian approximation for time-dependent solutions of Langevin equations
Creators: name: Hasegawa, Yoshihiko
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We propose a variational superposed Gaussian approximation (VSGA) for dynamical solutions of Langevin equations subject to applied signals, determining time-dependent parameters of superposed Gaussian distributions by the variational principle. We apply the proposed VSGA to systems driven by a chaotic signal, where the conventional Fourier method cannot be adopted, and calculate the time evolution of probability density functions (PDFs) and moments. Both white and colored Gaussian noises terms are included to describe fluctuations. Our calculations show that time-dependent PDFs obtained by VSGA agree excellently with those obtained by Monte Carlo simulations. The correlation between the chaotic input signal and the mean response are also calculated as a function of the noise intensity, which confirms the occurrence of aperiodic stochastic resonance with both white and colored noises.
description: 22 pages, 12 figures
Taufe, Glaube und Zugehörigkeit zur Kirche
Creators: name: Benedikt XVI., Papst
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 3 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 3
Involvement of Carrot Cell Surface Proteins in Attachment of Agrobacterium tumefaciens
Creators: name: Gurlitz, R. H. G.
name: Matthysse, A. G.
name: Lamb, P. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: The initial step in tumor formation by Agrobacterium tumefaciens is the site-specific attachment of the bacteria to plant cells. A similar attachment to plant tissue culture cells has been observed. Binding to carrot suspension culture cells was not dependent on the presence of divalent cations and was not inhibited by the addition of mannose, alpha-methyl mannoside, galactose, arabinose, glucosamine, 2-deoxyglucose, or 0.25 molar NaCl to the culture medium. The ability of the carrot cells to bind A. tumefaciens was markedly reduced by elution of the cells with dilute detergent or CaCl(2) or by incubation of the cells with proteolytic enzymes. The carrot cells were not killed by these treatments and recovered the ability to bind A. tumefaciens within 3 to 6 hours. A. tumefaciens did not bind to carrot cells which had been induced to form embryos (AG Matthysse, RHG Gurlitz 1982 Physiol Plant Pathol 21: 381-387). A comparison of the peptides eluted from embryos and from uninduced cells using sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that there were several changes in extractable polypeptides after embryo induction. One or more of the polypeptides present before embryo induction and absent from embryos may be involved in the binding of A. tumefaciens to the carrot cell surface.
Quantum transport in Rashba spin-orbit materials: A review
Creators: name: Bercioux, Dario
name: Lucignano, Procolo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In this review article we describe spin-dependent transport in materials with spin-orbit interaction of Rashba type. We mainly focus on semiconductor heterostructures, topological insulators, graphene and hybrid structures involving superconductors as well. We start from basic properties of Rashba Hamiltonian in a two dimensional electron gas and then describe transport properties in two- and quasi-one-dimensional systems. The problem of spin current generation and interference effects in mesoscopic devices is described in detail. We address also the role of Rashba interaction on localisation effects in lattices with nontrivial topology, as well as on the Ahronov-Casher effect in ring structures. A brief section, in the end, describes also some related topics including the spin-Hall effect, the transition from weak localisation to weak anti localisation and the physics of Majorana Fermions in hybrid heterostructures involving Rashba materials in the presence of superconductivity.
description: 28 pages and 21 figures, Revised in the text and bibliography compared to first version
Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy
Creators: name: Akhtari, Farida S.
name: Reif, David M.
name: Small, George W.
name: Quintanhila, Julia
name: Gonzalez, Ricardo D.
name: McLeod, Howard L.
name: Sikes, Michael
name: Green, Adrian J.
name: Wiltshire, Tim
name: Motsinger-Reif, Alison A.
name: Havener, Tammy M.
Publisher: name: MDPI
Year: 2023

description: Monoclonal antibody (mAb) therapy directed against CD20 is an important tool in the treatment of B cell disorders. However, variable patient response and acquired resistance remain important clinical challenges. To identify genetic factors that may influence sensitivity to treatment, the cytotoxic activity of three CD20 mAbs: rituximab; ofatumumab; and obinutuzumab, were screened in high-throughput assays using 680 ethnically diverse lymphoblastoid cell lines (LCLs) followed by a pharmacogenomic assessment. GWAS analysis identified several novel gene candidates. The most significant SNP, rs58600101, in the gene MKL1 displayed ethnic stratification, with the variant being significantly more prevalent in the African cohort and resulting in reduced transcript levels as measured by qPCR. Functional validation of MKL1 by shRNA-mediated knockdown of MKL1 resulted in a more resistant phenotype. Gene expression analysis identified the developmentally associated TGFB1I1 as the most significant gene associated with sensitivity. qPCR among a panel of sensitive and resistant LCLs revealed immunoglobulin class-switching as well as differences in the expression of B cell activation markers. Flow cytometry showed heterogeneity within some cell lines relative to surface Ig isotype with a shift to more IgG+ cells among the resistant lines. Pretreatment with prednisolone could partly reverse the resistant phenotype. Results suggest that the efficacy of anti-CD20 mAb therapy may be influenced by B cell developmental status as well as polymorphism in the MKL1 gene. A clinical benefit may be achieved by pretreatment with corticosteroids such as prednisolone followed by mAb therapy.
Veränderung des Begriffs »Zugehörigkeit zur Kirche«
Creators: name: Congar, Yves
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 3 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 3
Additional file 1: of FortiColos â   a multicentre study using bovine colostrum as a fortifier to human milk in very preterm infants: study protocol for a randomised controlled pilot trial
Creators: name: Ahnfeldt, Agnethe
name: Hyldig, Nana
name: Yanqi Li
name: Kappel, Susanne
name: Aunsholdt, Lise
name: Sangild, Per
name: Zachariassen, Gitte
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SPIRIT Checklist for FortiColos: Recommended items to address in a clinical trial protocol and related documents. (DOCX 58 kb)
High order cumulants of the azimuthal anisotropy in the dilute-dense limit: Connected graphs
Creators: name: Skokov, Vladimir
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We analytically compute higher order cumulants of the azimuthal anisotropy, $c_2\{2m\}$, and corresponding $v_2\{2m\}$ at high transverse momentum in the dilute-dense limit. The dense target is considered in the framework of the McLerran-Venugopolan model. The absolute values of the harmonics $v_2\{2m\}$ of the azimuthal anisotropy are approximately equal, $|v_2\{2m\}| \approx |v_2\{2m'\}| $, for large $m$ and $m'$. However, the harmonics with order $2m=4n$ are complex. We argue that this is a generic property of connected graphs, which remains true in the dense-dense limit.
description: 7 pages, 3 figures; version accepted to Phys. Rev. D
Location of Transported Auxin in Etiolated Maize Shoots Using 5-Azidoindole-3-Acetic Acid
Creators: name: Jones, A. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: A study was undertaken using the photoaffinity labeling agent tritiated 5-azidoindole-3-acetic acid to identify cells in the etiolated maize shoot which transport auxin. This transport was shown to be polar, inhibited by TIBA and essentially freely mobile.A study was undertaken using the photoaffinity labeling agent tritiated 5-azidoindole-3-acetic acid to identify cells in the etiolated maize shoot which transport auxin. This transport was shown to be polar, inhibited by TIBA and essentially freely mobile.
Additional file 3: of Ultrasonographic length of morphologically-normal kidneys in children presented to a premier tertiary healthcare setting of Sri Lanka
Creators: name: W. Duminda
name: K. Pathirana
name: M. Fernando
name: R. Samarasinghe
name: W. Ananda
name: K. Silva
name: C. Dissanayake
name: P. Mahesh
Publisher: name: Figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Supplementary Material 3: Normality testing of the variables. Normality test in findings of numerical variables. (DOCX 13 kb)
The role of Irish higher education institutions in national decarbonisation transitions
Creators: name: Horan, William
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: The overarching aim of this research is to assess the decarbonisation potential of sustainable technologies on Irish Higher Education Institution (HEI) campuses and to conceptualise the sector’s role in accelerating national sustainability transitions. The following elements describe the body of this research:On-Campus Decarbonisation Potential• Baseline of material and energy flows at Irish HEIs to estimate greenhouse gas emissions for the sector based on international best practice.• Identify the decarbonisation potential for the Irish HEI sector based on a novel method that utilises Geographic Information Systems (GIS) tools, official HEI campus maps and assumptions from the academic and technological literature.• Quantitative projections to estimate decarbonisation pathways for the Irish HEI sector up to 2030.HEI Role in Facilitating National Sustainability Transitions• Development and application of a novel integrated approach titled ‘Higher Education Advancing Development for Sustainability’ (HEADS) which utilises the perspectives of quantitative systems analysis, socio-technical analysis, and living lab learning to inform HEIs of their potential roles within national sustainability transitions.• A sustainability indicator set was developed to aid monitoring of sector performance in national sustainability transitions based on a review of bottom-up indicators from sustainability assessments at HEIs internationally and top-down indicators compiled from national agencies and bodies. • Exploration of possible wider application of methods adopted for the HEI sector for estimating potentials for decarbonisation in relation to industry and commerce sector.The results of this research suggest that there is significant potential for the Irish HEI sector to decarbonise its on-campus operations with the potential to reduce absolute scope 1 and 2 emissions by up to 36% by 2030. In addition, the role of HEIs as niche actors in facilitating national sustainability transitions was conceptualised and evaluated with HEI campuses identified as ideal test beds to experiment and deploy sustainability solutions at a scale that offers lessons to wider societal transitions. Application of methods adopted for the HEI sector to the industrial and commerce sector identified the potential to reduce carbon emissions by over 556 ktCO2 per annum using 2016 emission factors.
Zur Frage "Wer ist Glied der Kirche?"
Creators: name: Lehmann, Karl
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 3 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 3
PRAGMATIKANING RIVOJLANISH BOSQICHLARI
Creators: name: Sattorova, Feruza
Publisher: name: Zenodo
Year: 2023

description: Kommunikativ  qobiliyat rivojida faqat grammatik bilimni o'zi yetarli emas, balki pragmatik qobiliyatning rivoji ham muhim o'rin egallaydi. Tilshunoslikning pragmalingvistika sohasi kabi pragmatik qobiliyat tushunchasi ham juda salmoqli bo'lib, ushbu maqolada pragmatikaning paydo bo'lishi, rivojlanish bosqichlari, uning ichki bo'linishlari ko'rib chiqildi.
Abscisic Acid Elicits the Water-Stress Response in Root Hairs of Arabidopsis thaliana
Creators: name: Schnall, J. A.
name: Quatrano, R. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Water stress has been shown to cause root hairs to become short and bulbous. Because abscisic acid (ABA) mediates a variety of water-stress responses, we investigated the response of
Qualitative evaluation of barriers and facilitators to hepatocellular carcinoma care in North Carolina
Creators: name: Teal, Randall W.
name: Sanoff, Hanna K.
name: Coffman, Erin
name: Ray, Emily M.
name: Carda-Auten, Jessica
Publisher: name: Public Library of Science
Year: 2023

description: Background Many patients with hepatocellular carcinoma (HCC) never receive cancer-directed therapy. In order to tailor interventions to increase access to appropriate therapy, we sought to understand the barriers and facilitators to HCC care. Methods Patients with recently diagnosed HCC were identified through the University of North Carolina (UNC) HCC clinic or local hospital cancer registrars (rapid case ascertainment, RCA). Two qualitative researchers conducted in-depth, semi-structured interviews. Interviews were audiotaped, transcribed, and coded. Results Nineteen interviews were conducted (10 UNC, 9 RCA). Key facilitators of care were: physician knowledge; effective communication regarding test results, plan of care, and prognosis; social support; and financial support. Barriers included: lack of transportation; cost of care; provider lack of knowledge about HCC; delays in scheduling; or poor communication with the medical team. Participants suggested better coordination of appointments and having a primary contact within the healthcare team. Limitations We primarily captured the perspectives of those HCC patients who, despite the challenges they describe, were ultimately able to receive HCC care. Conclusions This study identifies key facilitators and barriers to accessing care for HCC in North Carolina. Use of the RCA system to identify patients from a variety of settings, treated and untreated, enabled us to capture a broad range of perspectives. Reducing barriers through improving communication and care coordination, assisting with out-of-pocket costs, and engaging caregivers and other medical providers may improve access. This study should serve as the basis for tailored interventions aimed at improving access to appropriate, life-prolonging care for patients with HCC.
Purification of Maize Pollen Exines and Analysis of Associated Proteins
Creators: name: Chay, C. H.
name: Thorn, J. M.
name: Buehler, E. G.
name: Whelan, T. M.
name: Bedinger, P. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: (maize) pollen exines have been purified with the use of differential centrifugation and sucrose gradients, followed by mild detergent and high salt treatment. The final exine fraction is highly purified from other organelles and subcellular structures as assayed by transmission electron microscopy. Using mature maize pollen as the starting material, 0.2 to 0.3% of the total pollen protein remained associated with the exine fraction throughout the purification. Seven abundant sodium dodecyl sulfate-extractable proteins are detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the final fraction. Amino acid analysis reveals that one of the proteins contains a substantial amount of hydroxyproline, a characteristic of some primary cell wall proteins. The amino acid composition of the 25-kD protein strongly implies that it is an arabinogalactan protein. When exines are purified from earlier pollen developmental stages, a subset of the proteins found in the mature pollen exine is seen.
Additional file 1: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node
Creators: name: Pul, Kim Van
name: Vuylsteke, Ronald
name: Rieneke Van De Ven
name: Velde, Elisabeth Te
name: Rutgers, Emiel
name: Petrousjka Van Den Tol
name: Stockmann, Hein
name: Gruijl, Tanja De
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Table S1. Phenotype of immune cell subsets. An overview of the used phenotypic definitions for each of the assessed immune subsets and analyzed activation/checkpoint molecules (PDF 510 kb)
Constraints on the septet-doublet mixing models from oblique parameters
Creators: name: Geng, Chao-Qiang
name: Tsai, Lu-Hsing
name: Yu, Yao
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The limitations of the doublet-septet mixing models by the deviations of electroweak oblique parameters $ΔS$ and $ΔT$ are studied. In the minimal model, the mixture of the septet $η$ and the scalar doublet in the standard model (SM) is driven by a non-Hermitian dimension-7 operator. For a smaller bare mass of the septet, $ΔS$ gives a stringent constraint on the mixing angle $\sinβ$ between the CP-odd neutral parts of the SM Higgs doublet and $η$. In general, increasing the mass of the scalar septet $M_η$ will enhance the deviation of $T$ from the SM, whereas it decreases the magnitude of $ΔS$ for a larger bare mass within the range $M_η\lesssim 400\,{\rm GeV}$. We also examine two extended models from the ordinary doublet-septet mixture pattern. One of them is based on a inert doublet-septet mixing pattern, in which there is no vacuum expectation value for the neutral component of $η$, and a stable dark matter could naturally exist. For a benchmark point with this inner doublet mass of $M_χ=250{\rm}$ and $M_η=400\,{\rm GeV}$ in this model, the mixing coefficient is found to be less than $1.8$. The other extension is constructed by imposing a doubly charged scalar mixed with the doubly charged component of the septet. Apart from the contribution by the septet-doublet admixture, $ΔS$ is suppressed by a factor of $s_W^2$ and $ΔT$ has a significant constraint due to the vanishing vacuum polarization of $Z$ at the momentum transfer $p^2=0$.
description: 19 pages, 3 figures, revised version accepted by PRD
Additional file 2: of Rationale and protocol of the ENGAGE study: a double-blind randomized controlled preference trial using a comprehensive cohort design to measure the effect of a cognitive and leisure-based intervention in older adults with a memory complaint
Creators: name: S. Belleville
name: A. Moussard
name: A. Ansaldo
name: P. Belchior
name: L. Bherer
name: N. Bier
name: V. Bohbot
name: M.-A. Bruneau
name: L. Cuddy
name: B. Gilbert
name: R. Jokel
name: K. Mahalingam
name: K. McGilton
name: K. Murphy
name: G. Naglie
name: E. Rochon
name: A. Troyer
name: N. Anderson
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Appendix 1. COMPASS-ND procedures by visit. Appendix 2. Sample size. Appendix 3. Dissemination plan. Appendix 4. Consent form of the ENGAGE study (participant version). Appendix 5. Consent form of the ENGAGE study (informant version). (DOCX 58 kb)
Correlation effects in double-Weyl semimetals
Creators: name: Lai, Hsin-Hua
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the long-range Coulomb interaction effects on the double-Weyl fermion system which is possibly realized in the three dimensional semimetal HgCr$_2$Se$_4$ in the ferromagnetic phase. Within the one-loop renormalization group analysis, we find that there exists a stable fixed point at which the Coulomb interaction is screened anisotropically. At the stable fixed point, the renormalized Coulomb interaction induces logarithmic corrections to the physical quantities such as specific heat, compressibility, diamagnetic susceptibility, and the finite frequency (dynamic) conductivity that are obtained utilizing RG equations near the stable fixed point.
description: 10 pages; 2 figures
title: Management Effects on the Performance of Double Cropping Systems - Results from a Multi-Site Experiment
Creators: name: Schmidt, Fruzsina
name: Böhm, Herwart
name: Piepho, Hans-Peter
name: Urbatzka, Peer
name: Wachendorf, Michael
name: Graß, Rüdiger
Publisher: name: Universität Kassel
Year: 2022
Subjects: subject: silage maize
subject: organic agriculture
subject: winter cover crop
subject: double cropping system
subject: roller-crimper
subject: tillage
subject: row width
subject: 630
subject: Deutschland
subject: Neu-Eichenberg
subject: Westerau-Trenthorst
subject: Fürstenfeldbruck-Puch
subject: Nachhaltigkeit
subject: Biomasse
subject: Maisanbau
subject: Silomais
subject: Längsschnittuntersuchung

description: Gefördert durch den Publikationsfonds der Universität Kassel
Geburtenarme Gesellschaften: ihre Mütter, ihre Kinder
Creators: name: Puder, Horst
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 2 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 2
HALOGEN: A tool for fast generation of mock halo catalogues
Creators: name: Avila, Santiago
name: Murray, Steven G.
name: Knebe, Alexander
name: Power, Chris
name: Robotham, Aaron S. G.
name: Garcia-Bellido, Juan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a simple method of generating approximate synthetic halo catalogues: HALOGEN. This method uses a combination of $2^{nd}$-order Lagrangian Perturbation Theory (2LPT) in order to generate the large-scale matter distribution, analytical mass functions to generate halo masses, and a single-parameter stochastic model for halo bias to position haloes. HALOGEN represents a simplification of similar recently published methods. Our method is constrained to recover the 2-point function at intermediate ($10Mpc/h
description: Submitted to MNRAS, 14 pages, 12 figures
Additional file 1: of Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism
Creators: name: Tamires Bitencourt
name: Macedo, Claudia
name: Matheus Franco
name: Rocha, Marina
name: Moreli, Igor
name: Cantelli, Bruna
name: Sanches, Pablo
name: Beleboni, Rene
name: Malavazi, Iran
name: Passos, Geraldo
name: Mozart Marins
name: Fachin, Ana
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Table S1. Genes modulated by Trichophyton rubrum during growth on protein sources, and after trans-chalcone exposure. (DOC 675 kb)