cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An optical tomography-based score to assess pediatric hand burns
Creators: name: Lindert, Judith Anne Teresa
name: Straube, Tina
name: Larsen, Beke
name: Siebert, Julia
name: Liodaki, Maria-Eirini
name: Tafazzoli, Kianusch
name: Wünsch, Lutz
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 618

description: To define the morphologic pattern of pediatric hand burns as visualized via optical coherence tomography (OCT) and dynamic OCT (D-OCT). We designed a scoring system to assess the depths of burn wounds on pediatric hands and tested this score in our cohort of children with burn injuries to the hand. Overall, 67 hand burns in 48 children (0–15 years) were prospectively examined. Scans were interpreted by two independent observers. Relevant OCT findings were surface irregularity, loss of epidermis, loss of dermal pattern (skin lines or papillary spots, loss of surface regularity and irregular vascular pattern of the plexus papillaris. Score values were calculated retrospectively. A score of 4 was associated with spontaneous healing without the need for skin grafting, with a positive predictive value of 97%. Deeper wounds with delayed healing and/or the need of skin grafting received a score of 5 or above, with an agreement of medical healing in 80% and a positive predictive value of 56%. OCT and D-OCT provide clinically useful additional information in cases of pediatric hand burns. The OCT burn score has the potential to support clinical decision making and, subsequently, improve clinical outcomes and shorten hospital stays.
Pichia pastoris Lab Scale Fermentation
Creators: name: Brady, Marcia
Publisher: name: Zenodo
Year: 2024

description: Pichia pastoris is recognized as an excellent expression system for heterologous protein production. Advantages of this expression host are, among others, the availability of strong and tightly regulated promoters, such as PAOX1, allowing the use of methanol as sole carbon source as well as inducer for recombinant protein production, and enabling the heterologous production of proteins up to several grams per liter, growth to high cell densities in mineral medium in fed-batch cultivation, the possibility to target proteins for secretion and the low amount of secreted endogenous proteins. P. pastoris has two alcohol oxidase encoding genes (AOX1 and AOX2), and three different phenotypes of P. pastoris host strains are available, according to their ability to metabolize methanol: the wild type (Mut+) and those resulting from deletions of AOX1 gene, (Muts) or both genes (Mut–).
Synthesis of rhodamine-conjugated lupane type triterpenes of enhanced cytotoxicity
Creators: name: Denner, Toni C.
name: Heise, Niels Valentin
name: Hoenke, Sophie
name: Csuk, René
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 540

description: Various conjugates with rhodamines were prepared by starting with betulinic acid (BA) and platanic acid (PA). The molecules homopiperazine and piperazine, which were identified in earlier research, served as linkers between the rhodamine and the triterpene. The pentacyclic triterpene’s ring A was modified with two acetyloxy groups in order to possibly boost its cytotoxic activity. The SRB assays’ cytotoxicity data showed that conjugates 13–22, derived from betulinic acid, had a significantly higher cytotoxicity. Of these hybrids, derivatives 19 (containing rhodamine B) and 22 (containing rhodamine 101) showed the best values with EC50 = 0.016 and 0.019 μM for A2780 ovarian carcinoma cells. Additionally, based on the ratio of EC50 values, these two compounds demonstrated the strongest selectivity between malignant A2780 cells and non-malignant NIH 3T3 fibroblasts. A375 melanoma cells were used in cell cycle investigations, which showed that the cells were halted in the G1/G0 phase. Annexin V/FITC/PI staining demonstrated that the tumor cells were affected by both necrosis and apoptosis.
Cyperus microiria Steud.
Creators: name: Info Flora
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Cyperaceae
Cyperus
Cyperus microiria

description: Cyperus microiria Steud.
Japanisches Zypergras
Art ISFS: 130150 Checklist: 1014430 Cyperaceae Cyperus Cyperus microiria Steud.
Bestimmungsschlüssel
Zusammenfassung
Artbeschreibung (nach Lauber & al. 2018): 10-30(-100) cm hoch, mit mehreren Stängeln. Diese im untersten Viertel von Blattscheiden umhüllt. Blätter 3-5 mm breit, kürzer als der Stängel. Blütenstand mit 3-8 Ästen, diese bis 10 cm lang, von 3-4 Hochblättern weit überragt. Ährchen locker ährig angeordnet. Tragblätter gelbbraun, mit grünen, in eine Spitze verlängerten Mittelrippen. Narben 3.
Blütezeit (nach Lauber & al. 2018): 8-9
Standort und Verbreitung in der Schweiz kollin / Von den Reisfeldern Oberitaliens gelegentlich bis ins südliche TI vordringend
Verbreitung global (nach Lauber & al. 2018): Stammt aus Ostasien
Ökologische Zeigerwerte (nach Landolt & al. 2010) 4w + 43-44 + 2.t.2n=?
Ökologie
Lebensform Therophyt
Lebensraum Lebensraumnach Delarze & al. 2015
KEINE ANGABE
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fsehr feucht; Feuchtigkeit stark wechselnd (mehr als ± 2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rneutral bis basisch (pH 5.5-8.5)Temperaturzahl Twarm-kollinNährstoffzahl Nmässig nährstoffarm bis mässig nährstoffreichKontinentalitätszahl Ksubozeanisch (hohe Luftfeuchtigkeit, geringe Temperaturschwankungen, eher milde Winter)
Nomenklatur
Gültiger Name (Checklist 2017):Cyperus microiriaSteud.
Volksname Deutscher Name: Japanisches Zypergras Nom français: Souchet du Japon Nome italiano: Zigolo giapponese
Übereinstimmung mit anderen Referenzwerken
RelationNomReferenzwerkeNo=Cyperus microiria Steud.Checklist 2017130150=Cyperus microiria Steud.Flora Helvetica 20012470=Cyperus microiria Steud.Flora Helvetica 20122646=Cyperus microiria Steud.Flora Helvetica 20182646=Cyperus microiria Steud.SISF/ISFS 2130150
= Taxon stimmt mit akzeptiertem Taxon überein (Checklist 2017)  Taxon enthält (neben anderen) auch das akzeptierte Taxon (Checklist 2017)
Status Indigenat: Neophyt: nach der Entdeckung von Amerika in der Region aufgetreten (nach 1500)
Liste der gefährdeten Pflanzen IUCN(nach Walter & Gillett 1997): Nein
description: Published as part of Info Flora, 2021,
Strategies to Support Developing Talent
Creators: name: Fuchslocher, Jörg
name: Romann, Michael
name: Gulbin, Jason P.
Publisher: name: Rubmedia
Year: 2013
Subjects: Talentförderung EHSM PISTE

description: The high performance unit within the Swiss Federal Institute of Sports Magglingen (SFISM) is chartered with supporting talented athletes via its collective inputs to students, athletes, coaches and national sporting federations. This is achieved by drawing upon the multi-disciplinary expertise of practitioners in the areas of sports medicine, recovery and rehabilitation, training science, sports psychology, nutrition, endurance and power physiology, strength and conditioning, and data management. This critical mass of specialists provides opportunities to collaborate “broadly” across a specific talent theme (e.g. on what basis should we select future sporting talent?), as well as the provision of sufficient content expertise to provide “deeper” knowledge and insights related to these interdisciplinary discussions (e.g. how can we account for biological maturity?). Therefore, this paper presents an example of the “broad” interdisciplinary work undertaken by SFISM to improve talent selection, and the complementary “deep” work used to investigate biological maturation as one component of this process. New and ongoing projects will continue to harness the collective potential of the multidisciplinary experts to better understand the processes of talent identification, selection, and development at the broadest and deepest levels. Our collective ability to support Switzerland’s best and brightest talent will require us to maximise the considerable expertise of the many stakeholders which influence and impact on development.
Aquaforum: Eine tier- und umweltfreundliche Aquakultur
Creators: name: Nipp, Eno
Publisher: name: Swiss Professional Media
Year: 2021
Subjects: Aquakultur

description: Die Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften der Berner Fachhochschule (BFH-HAFL) und das Inforama lancieren das «Aquaforum».
Hay preferences in horses versus selection by their owners
Creators: name: Holzer, Sonia Mélinda
name: Herholz, Cornelia
name: Tanadini, Lorenzo
name: Ineichen, Simon
name: Julliand, Samy
Publisher: name: Elsevier
Year: 2022
Subjects: Horse breed Forage Free choice experiment Nutritional requirement

description: The objective of the present study was to evaluate the differences in the selection behaviour by horses and by their owners given a choice of three hay types differing in chemical and nutritional composition. Horse groups included 12 French mountain (FM) stallions, 12 Icelandic (IS) and 12 warmblood horses (WB), with the latter groups consisting of mares and geldings. Hays were offered in a free choice experiment over a period of six consecutive days (baseline choice on day 1, adaption period from day 2-5 and a final preference test on day 6). Additionally, the owners of the horses selected among the three hay types, the one which they assumed would best meet their horse’s assumed nutritional requirements. Hay types (A, B and C) showed distinct characteristics based on colour, texture morphology and odour and nutrient contents. The latter were analysed with near-infrared spectroscopy. Most horses (69%) preferred hay type B and 31% preferred hay type C, while horses completely avoided hay type A. The group of FM horses exclusively preferred hay B on both test days, the groups of IS and WB horses also showed a preference for hay B, but less pronounced than FM horses choosing both between hay B and C, respectively. Horses did not choose randomly among the hays offered (P < 0.05). In addition, the horses hay preference was influenced by their group assignment (P < 0.05) which, however, cannot be generalized to breed or gender (mares, stallions or geldings). The content of crude protein (r=0.68), and leaves (r=0.48) of the hay was positively correlated with the preference of the horses for that particular hay type, although correlations were moderate. Among the owners, 42% chose hay type A, which was completely avoided by the horses, while approximately 30 % of the owners chose either hay type B or C, which were richer in energy and protein as the best hay quality for their horses assumed nutritional requirements. Therefore, no significant correlation could be observed between the choice preference of the horses and the selection by the owners. The distinct preference for energy- and protein-rich hay of horses underlines the importance for owners to carefully adjust the hay quality to the horse’s activity level and requirements. For horses with lower energy requirements, omission of concentrate feeds, while providing roughage only diets by mixing different hays qualities, appears suitable.
Additional file 1: Table S1. of Long-term immunogenicity and safety after a single dose of the quadrivalent meningococcal serogroups A, C, W, and Y tetanus toxoid conjugate vaccine in adolescents and adults: 5-year follow-up of an open, randomized trial
Creators: name: Borja-Tabora, Charissa
name: Montalban, Cecilia
name: Memish, Ziad
name: Boutriau, Dominique
name: Devayani Kolhe
name: Miller, Jacqueline
name: Wielen, Marie Van Der
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Plant Biology

description: Percentage of participants with rSBA antibody titers above the cut-off and GMTs (ATP cohort for persistence Year 5). Table S2. Percentage of participants per age strata with rSBA titers above the cut-off and GMTs (Total Cohort Year 5). Percentage of participants per age strata with rSBA antibody titers â Ľ1:8 and â Ľ1:128 and geometric mean titers in the ACWY-TT and the Men-PS groups at pre-vaccination, at Years 4 and 5 (Total Cohort Year 5). (DOC 111 kb)
Additional file 10 of Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models
Creators: name: Brackley, Chris
name: Brown, Jill
name: Waithe, Dominic
name: Babbs, Christian
name: Davies, James
name: Hughes, Jim
name: Buckle, Veronica
name: Marenduzzo, Davide
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Hematology
subject: Plant Biology
subject: Computational Biology

description: Figure S8. Interactions between Î˛ globin promoters and specific regulatory elements can be identified in each simulated conformation. (PDF 261 kb)
MOESM1 of Economic evaluations of interventions to reduce neonatal morbidity and mortality: a review of the evidence in LMICs and its implications for South Africa
Creators: name: Maredza, Mandy
name: Lumbwe Chola
name: Hofman, Karen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 1: Database searches.
Additional file 3: Table S2a and S2b. of The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects
Creators: name: Kok, Dieuwertje
name: Dhonukshe-Rutten, Rosalie
name: Lute, Carolien
name: Heil, Sandra
name: AndrĂŠ Uitterlinden
name: Velde, Nathalie Van Der
name: Meurs, Joyce Van
name: Schoor, Natasja Van
name: Hooiveld, Guido
name: Groot, Lisette De
name: Kampman, Ellen
name: Steegenga, Wilma
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Differentially methylated positions and regions related to serum levels of folate, vitamin B12 of plasma homocysteine. Overview of the top-10 of a) differentially methylated positions as well as b) regions related to serum levels of folate, vitamin B12 of plasma homocysteine.
Additional file 3 of Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models
Creators: name: Brackley, Chris
name: Brown, Jill
name: Waithe, Dominic
name: Babbs, Christian
name: Davies, James
name: Hughes, Jim
name: Buckle, Veronica
name: Marenduzzo, Davide
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Figure S2. ChIP-seq and DNase-seq data are used as an input to the model. (PDF 420 kb)
Die Sozialhilfe - Spiegel des wirtschaftlichen und gesellschaftlichen Wandels
Creators: name: Beyeler, Michelle
name: Salzgeber, Renate
Publisher: name: Berner Fachhochschule BFH, Soziale Arbeit
Year: 2020

description: Seit rund 20 Jahren beobachten Schweizer Städte die Entwicklungen in der Sozialhilfe. Durch den jährlichen Kennzahlenvergleich können Verschiebungen in den Armutsrisiken verschiedener Bevölkerungsgruppen früh erkannt werden. Gesunken ist der Sozialhilfebezug bei den jungen Erwachsenen, während er bei den über 45-Jährigen steigt.
Formation of alanine, α-aminobutyrate, acetate, and 2-butanol during cheese ripening by Pediococcus acidilactici FAM18098
Creators: name: Eugster, Elisabeth
name: Fuchsmann, Pascal
name: Schlichtherle-Cerny, Hedwig
name: Bütikofer, Ueli
name: Irmler, Stefan
Publisher: name: Elsevier
Year: 2019

description: There is limited information about the contribution of Pediococcus acidilactici, a nonstarter lactic acid bacteria, to cheese ripening and flavour development. Model Tilsit-type and Gruyère-type cheeses were produced using P. acidilactici FAM18098 as an adjunct. The adjunct did not influence the cheese manufacturing processes. The pediococcal log counts ranged from 7.0 to 8.0 cfu g-1 after 90 and 120 days of ripening. P. acidilactici produced ornithine, a result of arginine metabolism by the arginine deiminase pathway, and a-aminobutyrate and alanine while simultaneously metabolising serine and threonine. The analysis of the volatile compounds in the cheeses showed that higher acetate, 2-butanone, and 2-butanol levels and lower diacetyl levels were present in the cheeses produced with P. acidilactici than in the control cheeses. The study illustrates that P. acidilactici can influence amino acid metabolism in cheese; further, ornithine, a-aminobutyrate, and acetate can serve as indicators for the presence of this species. © 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Therapeutic lead discovery using graph deep learning
Creators: name: Gonzalez Pigorini, Guadalupe Gabriela
Publisher: name: Imperial College London
Year: 2023

description: Novel drug lead identification is a key challenge in the development of new therapies against cancer. While natural compounds were initially preferred for their evolutionary honed properties, high-throughput screening shifted focus to synthetic compounds. This approach, however, has resulted in limited success so far. As a result, recent years have seen a revival of natural products as promising sources for lead discovery. We posit that the recent developments in computational network-based methods for drug development can further push the revival of natural product-based drug discovery. In this dissertation, we introduce novel approaches for therapeutic lead discovery using graph-based deep learning methods. The first part of this dissertation explores the use of graph-based deep learning methods to predict therapeutic leads from molecules found in foods, either as single agents or in combination with existing anticancer drugs. Our results show promise for the exploration of natural compounds and their relationships with drugs across other diseases. In the second part of this dissertation, we outline the limitations of the current lead discovery problem formulation and propose a novel problem formulation that overlaps with lead design, therefore expanding the search space. To solve this problem formulation, we introduce an algorithm that combines the rigor of causal inference with the representation power of graph neural networks. Our algorithm predicts perturbagens that shift cell states from an initial to a desired target state across various genetic and chemical perturbation datasets and opens the door for the development of new, more flexible methods, for lead discovery. By introducing a fresh problem formulation for lead discovery, this dissertation sets the stage for more nuanced and effective strategies to lead discovery in cancer research.
Additional file 1: Figure S1. of Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse
Creators: name: Schedin-Weiss, Sophia
name: Caesar, Ina
name: Winblad, Bengt
name: Blom, Hans
name: Tjernberg, Lars
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Competition of GTB with active site inhibitor JC18 in hippocampal neurons. Figure S2. Negative controls for STORM. Figure S3. STORM imaging of the variation of γ-secretase in synapses. Figure S4. STED imaging showing the variation of γ-secretase labeling at synapses of triple stained mouse primary hippocampal neurons. Figure S5. STED confocal imaging of γ-secretase at the synapses of quadruple-stained mouse primary hippocampal neurons. Figure S6. Quantification of γ-secretase staining in synapses from STORM and STED data. (PDF 17769 kb)
Generating Perspectives: Applying Generative Design to critically explore the Atlas of Swiss Folklore
Creators: name: Frischknecht, Max
Year: 2022
Subjects: Generative Design
Data Visualisation
Digital Humanities
Cultural Anthropology
Critical Cartography

description: The poster addresses generative design as a methodology for a critical-visual exploration of the 1940s Atlas of Swiss Folklore. When we look at visualizations, we are often intrigued by the idea that they represent naturally existing phenomena through visual form. This poses a challenge to humanities scholars who interpret context-dependent data that represents complex social interweaving that unwind across time and space. The data beneath the Atlas of Swiss Folklore, for example, is the product of a perennial and multilayered process of collection and analysis. This interpretative framework is often no longer comprehensible in the finished visualizations leading to the impression of unambiguous visual statements. But rather than depicting unique meaning, visualizations should invite the viewer to critically question what is being viewed and the circumstances of its creation. The poster presents Generative Design is a promising approach that utilizes morphology and iteration to create a plurality of visualizations. Through Generative Design the Atlas of Swiss Folklore and its circumstances of creation can be examined from different perspectives. Generative Design can be used, for example, to visualize the locations of the atlas data collection in different contexts and thus help evaluate which parts of the population the maps of the atlas are representative or not.
Additional file 2: Figure S2. of Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome
Creators: name: Giloteaux, Ludovic
name: Goodrich, Julia
name: Walters, William
name: Levine, Susan
name: Ley, Ruth
name: Hanson, Maureen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: Principal Coordinate Analysis (PCoA) plot of healthy controls versus subjects with ME/CFS. Distances were calculated with weighted UniFrac (a) and unweighted UniFrac (b). Data were evenly sampled at 32223 sequences per sample. (PDF 2631Â kb)
Fostering Innovation, Transition, and the Reconstruction of Forestry: Critical Thinking and Transdisciplinarity in Forest Education with Strategy Games
Creators: name: Waeber, Patrick Olivier
name: Melnykovych, Mariana
name: Riegel, Emilio
name: Chongong, Leonel V.
name: Lloren, Regie
name: Raher, Johannes
name: Reibert, Tom
name: Zaheen, Muhammad
name: Soshenskyi, Oleksandr
name: Garcia, Claude
Publisher: name: MDPI
Year: 2023
Subjects: MineSet Innovations in teaching Transformative learning Serious games RPGs Role-play games Sustainable forest landscape governance Social innovation

description: Forest education plays a crucial role in achieving the Sustainable Development Goals and promoting sustainable forest management amidst global challenges. However, existing programs struggle to keep pace with rapidly evolving crises and uncertainties that contribute to deforestation and forest degradation. To tackle these challenges, integrating innovative approaches into forest education is essential. This paper showcases the transformative use of a strategy game, MineSet, as an innovative teaching method for integrated forest management. The game facilitates deeply engaging experiences that provide unique insights into complex issues like deforestation. By assuming various stakeholder roles, graduate students actively engage with and confront the intricate tradeoffs inherent in forest management. This interactive and immersive role-play game not only fosters critical thinking skills but also promotes collaborative problem-solving, making MineSet a highly innovative and attractive tool in forest education. The importance of extended debriefings, facilitation throughout the game, and ongoing discussions should not be underestimated, as they establish meaningful and necessary connections between in-game events, validated educational material, and published research outcomes. Moreover, the game equips students with practical experience and a comprehensive understanding of landscape approaches, using the Congo Basin as a case study. We emphasize the potential of innovative forest education to foster sustainability, stimulate critical thinking, resolve conflicts, and prevent costly forest losses.
Lab or Reality: Entwicklung und Analyse von Geschäftsmodellen durch das kybernetische Unternehmensmodell Blue Company
Creators: name: Grösser, Stefan
Publisher: name: Springer
Year: 2015
Subjects: Geschäftsmodell
Simulation
Komplexität
System Dynamics
Blue Company

description: Die dynamische Komplexität in Unternehmen sowie zwischen Unternehmen und Markt hat im Laufe der letzten Jahre stark zugenommen. Mit den bisherigen Managementmethoden lässt sich diese Art der Komplexität nicht mehr hinreichend erfassen. Komplexitätsreduktion, obwohl nötig, führt insbesondere zur Vernachlässigung von dynamischen Sachverhalten mit der Konsequenz, dass statische und einfache Methoden in den obersten Führungsetagen regieren. Für strategische Entscheidungen, wie z. B. die Ausgestaltung von Geschäftsmodellen, kann dies weitreichende Folgen haben. Führungskräfte müssen lernen, einen höheren Komplexitätsgrad zu akzeptieren und zu meistern. Die kybernetische Unternehmenssimulation Blue Company© erlaubt das Experimentieren unter „Laborbedingungen“. Durch eine Substitution des Realsystems mithilfe eines computergestützten Simulationsmodells (Business Lab) können in sozio-ökonomischen Systemen Experimente durchgeführt sowie deren Auswirkungen auf erfolgskritische Größen untersucht werden. Voraussetzung hierfür ist ein intern und extern valides und transparentes Unternehmensmodell, um die im Business Lab identifizierten Auswirkungen in das Realsystem implementieren zu können. Die Blue Company© bietet die Möglichkeit, die Entwicklung von Geschäftsmodellen zu verbessern sowie die kurz- und mittelfristige Bewertung von Geschäftsmodellen schon im Vorfeld abzuschätzen. Dieser Beitrag positioniert die Blue Company© als kybernetisches Unternehmensmodell und zeigt deren Nutzen auf. Weitere Arbeiten sind nötig, um die Blue Company© für die Praxis direkt nützlich zu machen.
Additional file 4: Figure S3. of Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome
Creators: name: Giloteaux, Ludovic
name: Goodrich, Julia
name: Walters, William
name: Levine, Susan
name: Ley, Ruth
name: Hanson, Maureen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Confusion matrices for random forest analysis of microbial sequencing data (values are presented as %) and ROC area under the curve (AUC) values at the genus (a), species (b) and OTU (c) level. (PDF 1170Â kb)
ИССЛЕДОВАНИЕ КИСЛОТНОСТИ, А ТАКЖЕ СОДЕРЖАНИЯ ОБЩИХ И РЕДУЦИРУЮЩИХ САХАРОВ В ПЛОДАХ ВИШНИ РАЙОНИРОВАННЫХ СОРТОВ СВЕРДЛОВСКОЙ ОБЛАСТИ
Creators: name: Вяткин А.В.
name: Исакова М.Г.
Publisher: name: Zenodo
Year: 2024

description: В статье представлены результаты исследования кислотности, а также содержания общих и редуцирующих сахаров в плодах вишни средних сроков созревания сортов, районированных в Свердловской области. Установлено, что среднее значение содержания общих сахаров составляет 14,8±0,4% (минимум у сорта «Флора» – 13,1±0,4%; максимум у сорта «Стандарт Урала» – 16,2±0,5%). Среднее значение общих сахаров составляет 14,8±0,4% (минимум у сорта «Флора» – 13,1±0,4%; максимум у сорта «Стандарт Урала» –16,2±0,5%). Среднее значение кислотности составило 3,9±0,1ºТ (минимум 3,1±0,1ºТ – у сорта «Жаворонок» и максимум 4,8±0,2ºТ – у сорта «Стандарт Урала»). Таким образом, доказана целесообразность использования для дальнейших селекционных изысканий и переработки такого сорта, как «Жаворонок», а для диетической коррекции рациона такого сорта, как «Флора».
Blühstreifen fördern Honig- und Wildbienen
Creators: name: Ramseier, Hans
name: Füglistaller, Dominik
name: Lädrach, Christina
name: Ramseier, Christian
name: Rauch, Michael
name: Widmer Etter, Franziska
Publisher: name: Agroscope Liebefeld-Posieux ALP
Year: 2016
Subjects: bees
beneficials
flower strips
pollen
pollinators

description: Honig- und Wildbienen sind für die landwirtschaftliche Produktion und die Biodiversität unverzichtbar, doch sie sind weltweit unter Druck geraten. Neben der Varroa- Milbe, Krankheiten und Umweltgiften dürfte auch fehlende Nahrung ein wichtiger Stressfaktor sein. Mit Blühstreifen in der Kulturlandschaft soll deshalb die Trachtlücke von Ende Mai bis Ende Juli verringert werden. An der Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften HAFL wurden 2011–2015 Blühstreifenmischungen entwickelt, die Honig- und nichtspezialisierten Wildbienen in der trachtarmen Zeit Pollen und Nektar liefern, aber auch für landwirtschaftlich wichtige Nützlinge wie Schwebfliegen und Raubwanzen attraktiv sind. Ein Vergleich mit Extensivwiesen, Brachen und Säumen ergab, dass Blühstreifen vielen Honig- und nichtspezialisierten Wildbienen Nahrung bieten. Eine Fallstudie im Jahr 2015 mit Erdhummeln hat zudem gezeigt, dass die Nähe eines Blühstreifens die Volksentwicklung positiv beeinflusst. Ein weiterer positiver Aspekt von Blühstreifen dürfte auch darin liegen, dass sie die Nahrungskonkurrenz zwischen Honig- und Wildbienen auf den übrigen Blühflächen reduzieren.
Additional file 1 of Recalibrating disease parameters for increasing realism in modeling epidemics in closed settings
Creators: name: Bioglio, Livio
name: GĂŠnois, Mathieu
name: Vestergaard, Christian
name: Poletto, Chiara
name: Barrat, Alain
name: Colizza, Vittoria
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Information containing additional Tables and Figures on correlation between relative variations Î  and epidemic parameters. (PDF 416 kb)
Kicking off a Gig Work Career: Unfolding a Career Learning Cycle of Gig Workers
Creators: name: Zwettler, Clara Hedwig
name: Straub, Caroline
name: Spurk, Daniel
Publisher: name: Sage
Year: 2023
Subjects: gig work
career stages
online labor platforms
protean career
career learning cycles

description: We observe gig workers’ retrospective sense-making of their career development, from creating an account on online labor platforms to managing gigs successfully. Our data reveals that gig workers advance through three career stages in their initial career learning cycle. We identify each stage as characterized by stage-specific emotions and that they react with specific behaviors to gig work challenges. Gig work challenges that occur in the platform environment are namely the newbie challenge, the positioning and relational challenge, and the balancing challenge, which workers need to overcome in order to transition to the next stage. In line with contemporary career and protean career theory on career learning cycles, gig workers need to build a set of specialized skills and meta-competencies to be successfully navigate their careers. As an outcome of the here-described career learning cycle, gig workers develop an entrepreneurial identity aspiration, as they are empowered and can use the platform as a playground or stepping stone for entrepreneurial activities. Our paper, thus, develops an understanding of gig workers’ initial career learning cycle by examining the factors that enable gig workers to kick off a career and allow them to thrive and advance on the platforms professionally.
Additional file 12: Figure S6. of Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis
Creators: name: Watson, Andrew
name: Williams, Tom
name: Williams, Bryony
name: Moore, Karen
name: Hirt, Robert
name: T. Embley
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Host cell gene expression changes in KEGG pathways enriched for differentially expressed genes. Genes highlighted in cyan are significantly up-regulated upon infection with T. hominis, genes in red are down-regulated, and the expression of genes in purple does not significantly change. Genes were assigned to KEGG pathways [87] using the KOBAS annotation pipeline [88], and colours representing differential expression were assigned using the KEGG web server [122]. (PDF 613Â kb)
Ermüdungsversuche an Stahlbetonbalken mit und ohne Schubbewehrung
Creators: name: Frey, Rudolf
name: Thürlimann, Bruno
Publisher: name: ETH Zurich
Year: 1983
Subjects: WECHSELFESTIGKEITSPRÜFUNG (MATERIALPRÜFUNG)
STAHLBETON, SCHLAFF BEWEHRT (BAUSTOFFE)
BALKEN + TRÄGER (BAUSTATIK)
BEWEHRUNG IN BETONKONSTRUKTIONEN (BAUKONSTRUKTIONSTEILE)
REPEATED DYNAMIC STRESS TESTS (MATERIALS TESTING)
REINFORCED CONCRETE, UNSTRESSED (BUILDING MATERIALS)
BEAMS (STRUCTURAL ANALYSIS)
REINFORCEMENT OF CONCRETE STRUCTURES (STRUCTURAL ELEMENTS)
info:eu-repo/classification/ddc/690
Buildings

description: Bericht / Institut für Baustatik und Konstruktion ETH Zürich, 7801 (1)
description: ISBN:3-7643-1575-X
title: Labour market and inflation relationship indicator
Creators: name: Orlov, Dmitry
name: Postnikov, Evgeny
Publisher: name: Bank of Russia
Year: 2022
Subjects: subject: Economics and business
subject: FOS: Economics and business

description: The labour market is closely connected to inflation processes, and is therefore a key factor to consider in monetary policy decisions. Russian regions differ substantially in terms of employment, wages, migration flows and the age structure of their population. Therefore, the effects of regional changes in the labour market on prices may be different. Since the Central bank’s inflation targeting policy is pursued nationwide, it is important for a regulator to factor in regional heterogeneity when assessing the impact of changes in the labour market on inflation growth. This paper brings forward a composite indicator of the contribution of labour market changes to inflation increase – the Labour Market Indicator (LMI). To capture regional heterogeneity in terms of market labour indicators, regions are grouped into four clusters with different social, demographic and economic characteristics. We make the case that the impact of unemployment on inflation can be described as slight or moderate in Russia. The calculated quarterly LMI values are overall consistent with the actual effect of the labour market on inflation processes over the entire time horizon under study, which suggests that the estimates are reliable. The important benefit of the LMI is that it is possible to interpret and allows to assess the future impact of labour market on inflation one quarter ahead of available statistical data – which helps make better informed monetary policy decisions.
Additional file 8: Figure S5. of Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis
Creators: name: Watson, Andrew
name: Williams, Tom
name: Williams, Bryony
name: Moore, Karen
name: Hirt, Robert
name: T. Embley
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Phylogenetic analysis of PiggyBac transposons suggests a natural insect host for T. hominisâ   full tree. An expanded version of the tree from FigureÂ 4 including GI accessions for all included sequences. The accession number of the newly identified T. hominis sequence (Clade B) is XLOC_002128. (PDF 22Â kb)
Additional file 1: of Interventions to improve patientsâ   compliance with therapies aimed at lowering glycated hemoglobin (HbA1c) in type 1 diabetes: systematic review and meta-analyses of randomized controlled clinical trials of psychological, telecare, and educational interventions
Creators: name: Viana, Luciana
name: Marilia Gomes
name: Lenita Zajdenverg
name: Pavin, Elizabeth
name: Azevedo, Mirela
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: PRISMA 2009 Checklist. (DOC 63 kb)
Reliability and validity of trunk accelerometry-derived performance measurements in a standardized heel-rise test in elderly subjects
Creators: name: Schmid, Stefan
name: Hilfiker, Roger
name: Radlinger, Lorenz
Publisher: name: Department of Veterans Affairs, Rehabilitation Research and Development Service
Year: 2011

description: This cross-sectional study evaluated the intrasession reliability and concurrent validity of trunk accelerometry (with force plate measurements) for vertical ground reaction force and external mechanical power recorded during a standardized heel-rise (HR) test in 54 elderly subjects (mean +/- standard deviation age 81.2 +/- 6.4 yr). Peak force as well as peak and average power revealed intraclass correlation coefficients of >0.75 and low standard errors of measurement for both the force plate- and the accelerometer-based curves. Correlation coefficients for these variables ranged from 0.95 to 0.98. The accelerometry-derived variables indicated significantly lower absolute values. Trunk accelerometry can be used as a reliable and valid tool for the quantification of the HR test in the elderly population. However, due to several limitations in the protocol, the use of this tool can currently only be recommended in a test-retest manner. Therefore, more research is needed to fully validate this tool for clinical use.
Einen Zahn zugelegt
Creators: name: Schwaller, Patrick
Publisher: name: BFH
Year: 2017

description: Damit ein Zahnersatz von den Patienten und den Zahnärzten akzeptiert wird, muss das Produkt hohen ästhetischen Ansprüchen genügen. Zudem muss eine hohe Festigkeit und Zähigkeit erreicht werden, damit eine einwandfreie Funktion gewährleistet ist. Zusammen mit der Firma Straumann und der Fachhochschule Nordwestschweiz (FHNW) arbeitet die BFH an neuartigen Methoden zur Herstellung von Zahnersatz.
Additional file 1: of The influence of students’ prior clinical skills and context characteristics on mini-CEX scores in clerkships – a multilevel analysis
Creators: name: Rogausch, Anja
name: Beyeler, Christine
name: Montagne, Stephanie
name: Jucker-Kupper, Patrick
name: Berendonk, Christoph
name: Huwendiek, Sören
name: Gemperli, Armin
name: Himmel, Wolfgang
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Hematology

description: SAS statement and print-out of results. (DOCX 985 kb)
Restaurants gegen Food Waste
Creators: name: Markoni, Evelyn
name: Götze, Franziska
name: Mettler, Rahel
Publisher: name: Swiss Professional Media
Year: 2019

description: Die Ernährung trägt zum Klimawandel mit einem signifikanten Anteil von 21 Prozent an der Gesamtumweltbelastung bei. Besonders die Produktion und der Konsum tierischer Produkte, wie Fleisch und Fisch, aber auch Milch und Käse, belasten das Klima. Brisant diesbezüglich ist, dass ein Drittel der Lebensmittel, gemäss Schätzungen der FAO, zwischen Feld und Teller verloren gehen und folglich unnötig verschwendet werden.
Additional file 4: of Induction of targeted, heritable mutations in barley and Brassica oleracea using RNA-guided Cas9 nuclease
Creators: name: Lawrenson, Tom
name: Oluwaseyi Shorinola
name: Stacey, Nicola
name: Chengdao Li
name: ĂStergaard, Lars
name: Patron, Nicola
name: Cristobal Uauy
name: Harwood, Wendy
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Detailed methods for assembly of binary vectors with multiple sgRNAs using the Golden Gate MoCloToolKit. (DOCX 28 kb)
Vermögenseinkommen - Treiber der Ungleichheit
Creators: name: Fluder, Robert
name: Farys, Rudolf
name: Baumann, Hans
Publisher: name: Juso und Denknetz (Hrsg.) Edition 8
Year: 2021

description: Im Beitrag wird auf die Einkommens- und Vermögensungleichheit in der Schweiz eingegangen. Dabei werden die wichtigsten Treiber für die Ungleichheit thematisiert. Vermögenseinkommen stellt sich dabei einer der zentralen Treiber heraus, für die Ungleichheit von Einkommen und Vermögen.
Pflanzenbasierte Getränke – der weite Weg zur Milchalternative
Creators: name: Kopf, Katrin Annika
Publisher: name: Verlag Lebensmittel-Industrie
Year: 2020

description: Das Interesse der Verbraucher an pflanzenbasierten Milchalternativen nimmt zu. Die Frage stellt sich aber, inwieweit die vorhandenen Getränke auf dem Schweizer Markt wirklich eine Alternative zu Milch darstellen.
Enabling real-time adaptive radiotherapy
Creators: name: Barbone, Marco
Publisher: name: Imperial College London
Year: 2024

description: The success of radiotherapy relies on precisely targeting cancerous cells while minimising harm to healthy tissue. Real-time adaptive radiotherapy addresses the challenge of rapidly changing cancer positions, dynamically adjusting the radiation beam during treatment with the help of MR-linacs—integrating Magnetic Resonance Imaging (MRI) scanners with linear accelerators. However, this approach faces significant computing challenges. The process involves converting raw scanner signals into MRI images, transforming them into a patient model, reconstructing the delivered dose, and optimising treatment parameters. These computationally intensive steps must be executed quickly to ensure the effectiveness of real-time adaptive radiotherapy. The first contribution of the thesis introduces a novel parallelisation scheme tailored for Four Dimensional Magnetic Resonance Imaging (4D-MRI) data, effectively minimising multithreading overhead and concealing data transfer latency. This results in an efficient architecture for algorithms based on the golden angle stack-of-stars MRI reconstruction. One such algorithm has been implemented and accelerated using Graphics Processing Units (GPUs) to facilitate clinical applications. The second contribution aims to provide a methodology for predicting the performance of accelerators in the context of Monte Carlo (MC) simulations. The methodology is derived from GPU and Field Programmable Gate Array (FPGA) computational capabilities through benchmarks. It is then validated with Coulomb Scattering, assessing the accuracy of the forecasts. The results demonstrate that the model’s forecasted speedup assists in deciding the optimal accelerator, if any, to achieve the best performance. The third contribution of this thesis is Optimised Dose Planning Method (ODPM), an MC simulation for radiotherapy dose reconstruction designed to meet real-time adaptive radiotherapy time requirements. The use of accelerators for ODPM is analysed using performance modelling. The forecasted speedup is then used to design an architecture capable of meeting real-time adaptive radiotherapy time requirements. This contribution also introduces multiple mathematical, algorithmic, and architectural optimisations applicable to MC simulations and integrates them into ODPM.
Additional file 4: Figure S2. of Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis
Creators: name: Watson, Andrew
name: Williams, Tom
name: Williams, Bryony
name: Moore, Karen
name: Hirt, Robert
name: T. Embley
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 60506 Virology

description: Alignment of a selection of identified intron sequences. An alignment of novel T. hominis intron sequences predicted from our transcriptome, suggesting no conserved intron motif. The alignment was generated using MUSCLE [111] and visualised using SeaView [120]. (PDF 62Â kb)
Cyberinfrastructure for Life Sciences - iAnimal Resources for Genomics and Other Data Driven Biology
Creators: name: Reecy, J.
name: Carson, J.
name: McCarthy, F.
name: Koltes, J.
name: Fritz-Waters, E.
name: Williams, J.
name: Lyons, E.
name: Baes, Christine F.
name: Vaughn, M.
Year: 2014
Subjects: bioinformatics
breeding
analysis pipeline
high-performance computing
next generation sequencing
variant calling

description: Whole genome sequence, SNPs, copy number variation, phenotypes and other “-omics” data underlie evidence-based estimations of breeding value. Unfortunately, the computational resources (data storage, high-performance computing, analysis pipelines, etc.) that exploit this knowledge are limited in availability – many investigations are therefore restricted to the commercial sector or well-funded academic programs. Cyberinfrastructure developed by the iPlant Collaborative (NSF-#DBI0735191) and its extension iAnimal (USDA-#2013-67015-21231) provides the animal breeding community a comprehensive and freely available platform for the storage, sharing, and analyses of large datasets – from genomes to phenotype data. iPlant/iAnimal tools support a variety of genotype-phenotype related analyses in a platform that accommodates every level of user – from breeder to bioinformatician. These tools have been used to develop scalable, accessible versions of common workflows required for applying sequencing to livestock genomics.