BindingDB Entry 50019766: Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Activin receptor type-1, Activin receptor type-2A, Bone morphogenetic protein receptor type-1B, Cyclin-G-associated kinase, Epithelial discoidin domain-containing receptor 1, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, LIM domain kinase 1, MAP/microtubule affinity-regulating kinase 3, MAP/microtubule affinity-regulating kinase 4, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase kinase kinase 20, NUAK family SNF1-like kinase 1, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor alpha/beta, Receptor-interacting serine/threonine-protein kinase 2, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MARK2, Serine/threonine-protein kinase NLK, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase receptor R3, TGF-beta receptor type-1, TGF-beta receptor type-2, TRAF2 and NCK-interacting protein kinase, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase ABL2, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Lyn, and Tyrosine-protein kinase Yes, Galapagos, Affinity

description: Small molecule binding data for protein Activin receptor type-1, Activin receptor type-2A, Bone morphogenetic protein receptor type-1B, Cyclin-G-associated kinase, Epithelial discoidin domain-containing receptor 1, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, LIM domain kinase 1, MAP/microtubule affinity-regulating kinase 3, MAP/microtubule affinity-regulating kinase 4, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase kinase kinase 20, NUAK family SNF1-like kinase 1, Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor alpha/beta, Receptor-interacting serine/threonine-protein kinase 2, Serine/threonine-protein kinase MARK1, Serine/threonine-protein kinase MARK2, Serine/threonine-protein kinase NLK, Serine/threonine-protein kinase SIK1, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SIK3, Serine/threonine-protein kinase TBK1, Serine/threonine-protein kinase receptor R3, TGF-beta receptor type-1, TGF-beta receptor type-2, TRAF2 and NCK-interacting protein kinase, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase ABL2, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Lyn, and Tyrosine-protein kinase Yes, Uniprot A0A024RCL1, A3QNQ0, O00238, O14976, O43353, O60285, P00519, P05622, P06239, P06241, P07333, P07947, P07948, P08631, P10721, P16234, P26618, P27037, P27448, P36897, P37023, P37173, P41240, P42684, P51451, P53667, P57059, Q04771, Q08345, Q14164, Q14680, Q7KZI7, Q96L34, Q9H0K1, Q9NYL2, Q9P0L2, Q9UBE8, Q9UHD2, Q9UKE5, and Q9Y2K2