cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Applying the Draft Articles on the Responsibility of International Organizations: Making International Organizations Accountable
Creators: name: Leung, Valerie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: international organizations
capital controls
international responsibility
international wrongdoing

description: The primary aim of this research is to investigate whether the Draft Articles on the Responsibility of International Organizations (ARIO) which were completed in 2011 are an effective means of making IOs accountable for international wrongdoing. In order to determine this a hypothetical case was created based on the imaginary scenario that the IMF required its member states to eliminate capital controls as a condition for obtaining loans from the organization. This hypothetical case is argued on behalf of the borrowing states and thus the thesis in part has the form of a legal pleading. This approach was deliberately taken in order to provide a practical example of how the ARIO could be applied to any case related to the responsibility of IOs, not just the one under consideration here. The case is first used to illustrate how the ARIO might be applied in order to determine whether an IO’s conduct amounts to international wrongdoing and results in international responsibility. Secondly, the case is employed to demonstrate whether the ARIO provide remedies for parties injured as a result of international wrongdoing committed by IOs thereby bringing the latter to accountability. At the end of the investigation it is apparent that conduct such as the IMF’s fictional conduct in relation to its policy would amount to international wrongdoing by an IO in light of the ARIO and would incur international responsibility. However, in the course of applying the ARIO to this fictional case, it becomes evident that although the ARIO are effective for establishing the international responsibility of IOs, they are ineffective as a means of making them accountable for any responsibility they incur because they provide various escapes from the legal consequences for international responsibility. It is therefore concluded that IOs are free to continue to engage in international wrongdoing with impunity despite the creation of the ARIO.
Existence, Expectation, and Interference: A Corpus Stylistics Study of Word Clusters in Jane Austen’s Works
Creators: name: Suhandoko, Suhandoko
name: Suhandoko, Suhandoko
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470404
subject: Corpus linguistics

description: The study examines the thematic and stylistic elements in Jane Austen’s novels by examining the word clusters. The computational analysis using AntConc concordance software focuses on finding the recurring bi-grams and tri-grams that potentially explain Austen’s narrative style. The finding of the study suggests that word clusters like “to be”, “it would be,” and “could not be” are key features in Austen’s narrative technique to portray the existence, expectations, and interference women encountered within patriarchal society during the era. This corpus stylistics approach helps confirm the significance of Austen’s writings in understanding the societal construct in the era and provides quantitative evidence to support traditional literary analysis.
Additional file 1 of Chromosome-scale scaffolds of the fungus gnat genome reveal multi-Mb-scale chromosome-folding interactions, centromeric enrichments of retrotransposons, and candidate telomere sequences
Creators: name: Urban, John M.
name: Gerbi, Susan A.
name: Spradling, Allan C.
Publisher: name: figshare
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1.
Intimate Partner Aggression and Relationship Satisfaction across Attachment Styles
Creators: name: Bonneville, Alyssa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Intimate Partner Aggression
Aggression
Attachment Styles
Relationship Satisfaction

description: This study presents a quantitative study exploring intimate partner aggression (i.e. physical, verbal, relational) and relationship satisfaction across attachment styles (i.e. avoidant, anxious, secure, and fearful). This study analyzed 170 participants, of which 77.8% were female participants and 22.2% were male participants. The sample ranged from ages 20 to 70 and the mean age of the sample was 31.34 (SD = 11.73). The average relationship length of the sample was 7.76 years (SD = 9.18). This study found that the fearful attachment style is most at risk of engaging in verbal and relational aggression with their intimate partners. Secure attachment was found to have the highest levels of relationship satisfaction, whereas the fearful attachment style had the lowest scores of relationship satisfaction. Finally, relationship length was found to have an effect on relationship satisfaction. Overall, the current study targeted critical areas in the scientific literature and created a starting block into research focusing on intimate partner aggression and relationship satisfaction across attachment styles.
4669-Article Text-12360-1-10-20240630.pdf
Creators: name: Suhandoko, Suhandoko
name: Suhandoko, Suhandoko
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470404
subject: Corpus linguistics

description: The study examines the thematic and stylistic elements in Jane Austen’s novels by examining the word clusters. The computational analysis using AntConc concordance software focuses on finding the recurring bi-grams and tri-grams that potentially explain Austen’s narrative style. The finding of the study suggests that word clusters like “to be”, “it would be,” and “could not be” are key features in Austen’s narrative technique to portray the existence, expectations, and interference women encountered within patriarchal society during the era. This corpus stylistics approach helps confirm the significance of Austen’s writings in understanding the societal construct in the era and provides quantitative evidence to support traditional literary analysis.
Efficient Simulation for Quantum Message Authentication
Creators: name: Wainewright, Evelyn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: quantum cryptography
message authentication
quantum information
trap code
Clifford code

description: A mix of physics, mathematics, and computer science, the study of quantum information seeks to understand and utilize the information that can be held in the state of a quantum system. Quantum cryptography is then the study of various cryptographic protocols on the information in a quantum system. One of the goals we may have is to verify the integrity of quantum data, a process called quantum message authentication. In this thesis, we consider two quantum message authentication schemes, the Clifford code and the trap code. While both of these codes have been previously proven secure, they have not been proven secure in the simulator model, with an efficient simulation. We offer a new class of simulator that is efficient, so long as the adversary is efficient, and show that both of these codes can be proven secure using the efficient simulator. The efficiency of the simulator is typically a crucial requirement for a composable notion of security. The main results of this thesis have been accepted to appear in the Proceedings of the 9th International Conference on Information Theoretic Security (ICITS 2016).
Additional file 1 of Engineering a newly identified alcohol dehydrogenase from Sphingobium Sp. for efficient utilization of nicotinamide cofactors biomimetics
Creators: name: Zhu, Yichun
name: Zhou, Jieyu
name: Gu, Xiangyuan
name: Wang, Huiru
name: Han, Hao
name: Ni, Ye
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology

description: Supplementary Material 1
The Church in Globalization: A World-Systems Analysis on the Influence of Liberalism in Modern Catholic Social Thought
Creators: name: Pump, Andrew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Catholic Social Thought
World-Systems Analysis
Liberalism
Marxism

description: It is within the realm of the international civil society that religions play out their important public roles as charities and advocacy organizations in globalization. World governance models in the post-Cold War era stress the important role that civil society plays in building and sustaining democracy. Indeed, the participation of the Catholic Church in the "third wave of democratization" confirms this. Yet, twenty-five years after the collapse of international socialism, problems with American-led models of development have come to the fore in glaring ways. Growing wealth inequality and what Gayatri Spivak calls "sustainable underdevelopment" are the norm, and these problems highlight the dangers and instability of liberal economic policies. Religious organizations, and proponents of the Catholic social tradition in particular, have been the strongest voices for advocating social justice and advancing policies that pursue "the common good." Both working to alleviate poverty as charities ([i]NGOs and FBOs) and using their voices as a "public religion" (José Casanova) in civil society, Catholic institutions navigate the historically constructed and contingent boundaries among the three spheres of the state, the market, and civil society. Studying this interplay has provided fruitful theories deconstructing the religious/secular binary. In light of these theories, this thesis applies the critique of liberalism supplied by world-systems analysis to the development of Catholic social thought, in the process highlighting a complex history of complicity and dissent with U.S. liberalism's unfolding hegemony. In circulating Catholic social thought through the economic focused paradigm of world-systems analysis, I explore the possibilities of seeing religion and globalization outside a culturally focused framework. How the social magisterium is responding to the problems of economic globalization in an increasingly unstable world will affect its future legitimacy. I explore where the Church has been and its capacity to be a continuingly proactive force for "social justice" and "the common good."
The Impact of the Recent Financial Crisis on Bank Lending to SMEs in Canada
Creators: name: Legendre, Nicolas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Financial Crisis
Medium-Sized Enterprises
Government intervention
Financing of Small

description: This study investigates the magnitude of credit contraction encountered by Canadian Small-and-Medium-Sized-Enterprises (SMEs) during the recent financial crisis of 2007-2008. These firms account for an important source of job creation and economic welfare (Haltiwanger et al., 2010); therefore, to ensure the creation and growth of SMEs through a smooth flow of capital is crucial for a healthy economic recovery from the crisis. The empirical observation obtained in this study is contrary to what the theory suggests, as well as what many of the existing studies witnessed (i.e., a financial crisis has a negative impact on SME loan circulations). Using binary probit regression and structural break testing, this work finds that Canadian SME loan approval and application rates were higher during the crisis period. This somewhat counterintuitive result prompts the researcher to search for the possible factors enabling SME credit lending in Canada to retain its health during the time of financial distress, which include: (1) the stability of Canadian banks evidenced by the relatively constant Capital Tier I ratio during the crisis; (2) initiatives the Canadian government implemented as a response to the crisis. This result also raises a question whether the five billion dollars the federal government injected in the SME lending market under the Business Capital Availability Program (BCAP), a measure designed to insulate Canadian SMEs from the liquidity shock, could be justified. This research question will be investigated as a future area of research.
Additional file 2 of Engineering a newly identified alcohol dehydrogenase from Sphingobium Sp. for efficient utilization of nicotinamide cofactors biomimetics
Creators: name: Zhu, Yichun
name: Zhou, Jieyu
name: Gu, Xiangyuan
name: Wang, Huiru
name: Han, Hao
name: Ni, Ye
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology

description: Supplementary Material 2
Capillary Electrophoresis for Separation of Biomolecules and Viruses
Creators: name: Gargaun, Ana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: capillary electrophoresis
virus
biomolecular interactions

description: This thesis examines the use of capillary electrophoresis for the study of several biomolecules and their interactions and viruses. The first two experimental chapters focus on its utility for thermodynamic and kinetic analysis of molecules. Chapter one focuses on the use of non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM), to calculate the dissociation constant for the interaction between double stranded microRNA-122 and protein p19. NECEEM was used to calculate the rate constants (koff = 0.059 ± 0.013 s-1, kon = 0.0022 ± 0.0008 s-1M-1) and the dissociation constant between miR-122 and wild type p19 (Kd = 27 ± 9 nM). A new method was developed to calculate the rate constant koff, by using multiple electric fields; which resulted in a koff value of 0.072 ± 0.022 s-1. In chapter two, the dissociation constant, Kd, was determined between HIV trans-activation response element and nuclear protein TOE1. It was demonstrated that TOE1, more specifically peptides ER19 and ED35, were binding to TAR with Kd values of 4.08 ± 0.19 µM for ER19 and 7.43 ± 1.60 µM for ED35. The discovery of the peptides’ inhibitory action of viral replication at the transcription level is a significant step towards further elucidating mechanisms for host response to HIV-1 infection. The third chapter focuses on the use of capillary electrophoresis for studying vesicular stomatitis virus (VSV) and vaccinia virus (VV). A new method was developed for quantification of VSV, using dithiothreitol. Furthermore, CE was used to study the preservation of VSV by a previously selected aptamer construct (quadramer) during freeze-thaw cycles. It was found that the infectivity of quadramer and aptamer pool-protected virus was higher than pure virus after 60 freeze−thaw cycles. It was also found that adding quadramers to the virus without freezing (cycle 0) increased the virus infectivity by 30%. We also investigated the potency of a carbohydrate-based ice recrystallization inhibitor, N-octyl-D-gluconamide (NOGlc) for its ability to eliminate the cold chain and stabilize the potency of VV. Viral potency after storage at room temperature demonstrated that NOGlc conserved the infectivity of VV, during 40 days.
L'impact des peines minimales sur les négociations de plaidoyer de culpabilité : les stratégies de la Couronne et de la Défense
Creators: name: Boucher, Alex
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: droit criminel
peine minimale obligatoire
plaidoyer de culpabilité
négociations
procureurs de la Couronne
avocats de la défense

description: Nous présentons ici une recherche qualitative et exploratoire sur une nouvelle facette d'un sujet bien exploré par la littérature, la négociation sur un plaidoyer de culpabilité. Il s'agira pour nous de considérer cette nouvelle variable qu'est la peine minimale obligatoire, beaucoup moins étudiée quant à elle, afin d'explorer si elle affecte ou non les négociations, comment et pourquoi. L'assise empirique, formée de discours de procureurs (Couronne et défense) issus d'entretiens semi-directifs, nous a permis d'observer comment les acteurs, dans cette action collective du système (droit criminel), se reconstruisent un discours face à l'objet traité dans cette étude. L'analyse des matériaux empiriques de ces deux groupes d'acteurs et la mise en relation entre elles nous ont permis d'observer de fortes tendances entre peines minimales et négociations. Les preuves empiriques qui se sont juxtaposées aux principales visées de cette recherche se révèlent être bien intéressantes sur le plan des connaissances. Nous parlons ici des points de vue des procureurs face aux peines minimales et les limites que ces peines imposent sur les objectifs et principes en matière de détermination de la peine, notamment sur les deux optiques de la proportionnalité qui permettent au droit criminel d'individualiser les peines. Ces limites sont ensuite reprises dans les rationalités des procureurs pour justifier la mise en œuvre de stratégies lors des négociations, stratégies qui viennent contrôler et réduire l'impact de cette ingérence politique dite populiste avec les peines minimales. En affectant tout de même la portée des négociations et la dynamique relationnelle entre procureurs, il n'en demeure pas moins que les peines minimales se répercutent ailleurs dans le système, particulièrement par l'augmentation de la tenue de procès.
Numerical Modeling of Extreme Flow Impacts on Structures
Creators: name: Asadollahi Shahbaboli, Nora
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Hydrodynamic force
Drag coefficient
Rectangular column
Aspect ratio
Structure orientation
Bed condition
Hydraulic bore
OpenFOAM

description: Recent tsunami disasters caused devastating damages to well-engineered coastal infrastructures. In fact, the current design guidelines are not able to provide realistic estimations of tsunami loads in order to design structures to withstand tsunamis. Tsunami hydrodynamic forces are estimated using the drag coefficient. This coefficient is traditionally calculated based on a steady flow analogy. However, tsunami bores behave like unsteady flows. The present work aims at investigating the tsunami forces for different structure geometries to provide realistic guidelines to estimate drag coefficients considering unsteady flows. In the present paper, the dam-break approach is used to investigate the tsunami-like bore interaction with structures. A three-dimensional multiphase numerical model is implemented to study the tsunami induced forces on rectangular shape structures with various aspect ratios (width/depth) and orientations. The numerical model results are validated using measured forces and bore surface elevations of the physical experiments. A scaled-up domain is modeled in order to eliminate the effects of domain sidewalls in the simulation results. The drag coefficient relations with structure geometries and bore depths are provided. The obtained hydrodynamic forces and drag coefficients are compared with existing data in the literature and design codes. For the second topic, a multi-phase three-dimensional numerical reproduction of a large scale laboratory experiment of tsunami-like bores interaction with a surface-piercing circular column is presented. The numerical simulation is conducted in OpenFOAM. The dam-break mechanism is implemented in order to generate tsunami-like bores. The numerical model is validated using the experimental results performed at Canadian Hydraulics Center of the National Research Council (NRC-CHC) in Ottawa. The unsteady Reynolds Averaged Navier-Stokes equations (RANS) are used in order to treat the turbulence effects. The Shear Stress Transport (SST) k-ω turbulence model showed high level of accuracy in replication of the bore-structure interaction. Further, a scaled-up domain is used to investigate the influence of the bed condition in terms of various downstream depths and roughness. Finally, a broad investigation on the bore propagation characteristics is performed. The resulting stream-wise forces exerted on the structural column as well as the bore velocity are compared and analyzed for smooth, rough, dry and wet beds with varying depths.
Cost-related medication nonadherence in Canada: a systematic review of prevalence, predictors, and clinical impact
Creators: name: Holbrook, Anne M
name: Wang, Mei
name: Lee, Munil
name: Chen, Zhiyuan
name: Garcia, Michael
name: Nguyen, Laura
name: Ford, Angela
name: Manji, Selina
name: Law, Michael R.
Publisher: name: BioMed Central
Year: 2021

description: Background: Cost-related nonadherence to medications (CRNA) is common in many countries and thought to be associated with adverse outcomes. The characteristics of CRNA in Canada, with its patchwork coverage of increasingly expensive medications, are unclear. Objectives: Our objective in this systematic review was to summarize the literature evaluating CRNA in Canada in three domains: prevalence, predictors, and effect on clinical outcomes. Methods: We searched MEDLINE, Embase, Google Scholar, and the Cochrane Library from 1992 to December 2019 using search terms covering medication adherence, costs, and Canada. Eligible studies, without restriction on design, had to have original data on at least one of the three domains specifically for Canadian participants. Articles were identified and reviewed in duplicate. Risk of bias was assessed using design-specific tools. Results: Twenty-six studies of varying quality (n = 483,065 Canadians) were eligible for inclusion. Sixteen studies reported on the overall prevalence of CRNA, with population-based estimates ranging from 5.1 to 10.2%. Factors predicting CRNA included high out-of-pocket spending, low income or financial flexibility, lack of drug insurance, younger age, and poorer health. A single randomized trial of free essential medications with free delivery in Ontario improved adherence but did not find any change in clinical outcomes at 1 year. Conclusion: CRNA affects many Canadians. The estimated percentage depends on the sampling frame, the main predictors tend to be financial, and its association with clinical outcomes in Canada remains unproven.
Le Sociogramme du civisme dans les Aventures de Blake et Mortimer
Creators: name: Chaplain Corriveau, Charles-Étienne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Sociocritique
Blake et Mortimer
Bande dessinée
Sociogramme

description: Cette thèse étudie l’évolution du civisme à travers l’ensemble des Blake et Mortimer dans une perspective sociocritique. Elle suggère qu’il existe une différente conception du civisme entre les bandes dessinées écrites par Edgar P. Jacobs (publiées de 1946 à 1977) et celles de ses continuateurs (parues de 1996 à 2014). Elle tente de montrer, plus exactement, à l’aide de la notion de sociogramme, comment les premières s’articulent autour d’un humanisme civique et les deuxièmes d’une forme de citoyenneté civile. Il s’agit donc, aussi, d’analyser les médiations sur lesquelles s’appuient chacune de ces deux perspectives afin de rendre compte du rééquilibre discursif qui a facilité, voire permis, cette transition.
The Role of Serotonin (5-HT) in Regulating the Hypoxic Hyperventilatory Response of Larval Zebrafish
Creators: name: Jensen, Gregory
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: hypoxia
chemoreception
neuroepithelial cell
tryptophan hydroxylase

description: Serotonin (5-HT) containing neuroepithelial cells (NECs) are O2 sensitive chemoreceptors found throughout the skin of larval zebrafish (Danio rerio). Zebrafish larvae are sensitive to changes in ambient PO2 as early as 2 days post fertilisation (dpf) and hyperventilate in response to hypoxia beginning at 3 dpf. Tryptophan hydroxylase (tph) is the rate-limiting enzyme in 5-HT synthesis; three tph paralogs are present in zebrafish (tph1a, tph1b and tph2). Although 5-HT has been implicated as a key neurotransmitter mediating hypoxic hyperventilation, it has not been possible to discern the role of 5-HT specifically contained within the NECs in promoting hypoxic hyperventilation. The purpose of this study was to determine the role of NEC 5-HT in regulating the hypoxic ventilatory response in larval zebrafish. It was hypothesised that 5-HT is a key neurotransmitter released from NECs which contributes to hypoxic hyperventilation. Immunohistochemistry was used to determine the distribution of tph paralogs and their role in 5-HT production in NECs. Tph1a was present in NECs and nerves innervating NECs. Exposure to the non-selective tph inhibitor, para-chlorophenylalanine (pCPA), or translational gene knockdown of tph1a, diminished 5-HT expression within NECs. Exposure to acute hypoxia (PO2 = 30 mmHg) revealed a blunted hypoxic ventilatory response (reduced breathing frequency) in fish exhibiting depleted 5-HT in NECs. The hypoxic hyperventilatory response was rescued with application of 5-HT. The results of these experiments demonstrate that tph1a is responsible for 5-HT production in NECs of larval zebrafish, and that 5-HT released from NECs is involved in establishing their hypoxic hyperventilatory response.
Additional file 1 of Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections
Creators: name: Vander Elst, Niels
name: Farmen, Kristine
name: Knörr, Lisa
name: Merlijn, Lotte
name: Iovino, Federico
Publisher: name: figshare
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1.
Apêndices do artigo intitulado "PoP Modeler: Uma ferramenta para facilitar a modelagem e compreensão de Processos-de-Processos de Negócio" (MSSiS 2024)
Creators: name: Gabriel de Mattia, Wellington
name: Franco, Igor
name: Nabarrete Costa, Murilo Gustavo
name: de Almeida Molina, Sidny
name: Barroso Paiva, Débora Maria
name: Cagnin, Maria Istela
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 460901
subject: Business process management

description: Apêndice A - Visões e respectivos modelos para representar PoP Apêndice B - Representação dos passos para o desenvolvimento da pesquisaApêndice C - Informação adicional sobre a análise, arquitetura e exemplo de uso do módulo PoP ModelingApêndice D - Resultados quantitativos da avaliação do módulo PoP Modeling
From Gerry-built to purpose-built: drawing electoral boundaries for unbiased outcomes
Creators: name: Newton-Farrelly, Jenni
Publisher: name: Swinburne
Year: 2024

description: Electoral bias causes unfair election results that call into question the legitimacy of governments and undermine confidence in the integrity of the electoral system. Biased electoral outcomes in the UK, Canada and Australia are often accepted as an inherent function of a single-member system, not remediable by independent boundary commissions because they are required to work without taking partisan considerations into account. Meanwhile the US Supreme Court cannot decide on a point beyond which bias should be struck down. Those who do not accept the inevitability of unfair election outcomes see proportional representation as the solution, but the cost-loss of the representational value of single member districts-makes this a contestable solution. But if boundaries could be drawn to produce an unbiased electoral system and generate fair electoral outcomes, single-member districts could be retained and confidence could be returned. South Australia requires its independent boundaries commission to do just that, and the results indicate that fair electoral outcomes can indeed be produced.
Influenza Virus Evades NK Cell Responses by Enhancing Ly49:MHC-I Interactions
Creators: name: Mahmoud, Ahmad Bakur
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: influenza
NK cells
unlicensed NK cells
Ly49 receptor

description: Natural killer (NK) cells are a type of innate immune cell that can identify and eliminate viral infected cells and cancer cells. NK cells express an array of inhibitory and activating receptors such as natural cytotoxicity receptors, the mouse Ly49 or human KIR family, and NKR-P1 family. The integration of signals that NK cells receive through these receptors controls their activation and ability to kill target cells. Both Ly49 and KIR recognize MHC-I molecules on healthy cells Ly49:MHC-I engagement is essential for functional NK cell development. In the absence of these interactions NK cell is consider as ‘uneducated’ or ‘unlicensed’. Ly49 receptor interactions with MHC-I are critical in an effective NK cell response against cancer. However, the role of unlicensed NK cells in NK-mediated control of viruses is poorly understood. Using NKCKD mice, we sought to determine how the loss of Ly49:MHC-I education, and the concomitant loss of inhibition via MHC-I, affected survival against influenza infection. In this study, we show that Ly49-deficient mice exhibit lower viral load and greater protection than WT mice when infected with influenza. However, this protection was lost when Ly49I was transgenically restored to these mice. Similarly, MHC-I-deficient mice, that also lack educated NK cells, were resistant to influenza infection, and lost this protection when NK cells were depleted before challenge. Based on the markedly reduced inflammation in the Ly49-deficient mice compared to the WT, we conclude that the Ly49-deficient NK cells are swifter and more effective in clearing influenza, resulting in less viral burden and consequentially less need for a dangerously aggressive inflammatory response. Furthermore, influenza infection enhanced MHC-I expression on lung epithelial cells, which could be responsible for inhibition of NK cells. Consequently, blockade of inhibitory Ly49C/I receptors protected WT mice from lethal influenza infection. Additionally, Perforin-deficient NKCKD succumbed to the infection demonstrating that NK cell directly eliminate influenza-infected cells. Collectively, these results confirm that influenza is capable of inhibiting NK cells through MHC-I engagement of KIR/Ly49, and suggests that blocking this interaction may provide a viable therapeutic avenue for severe influenza cases. these results challenge our understanding of basic NK cell function and suggest that, rather than subdividing NK cells into ‘licensed’ and ‘unlicensed’ based on their expression of self-specific Ly49 receptors, a more accurate depiction of these NK subsets would be ‘cancer-specialized’ and ‘pathogen-specialized’. While further work is required to fully test this paradigm of cancer- and pathogen-specialized NK cells, I hope that my findings will stimulate a new appreciation for the role of NK cells in virus control, and lead to a better understanding of this critical immune cell.
Morality in Plutarch's "Life of Cimon"
Creators: name: Giroux, Chandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Plutarch
Parallel Lives
Morality
Cimon
Euergetism

description: Understanding Plutarch’s Parallel Lives as a literary text is the focus of current scholarship. However, to this date, no one has looked at Plutarch’s Life of Cimon to analyze what it reveals about morality. My thesis endeavours to understand how Plutarch shapes Cimon as a literary character to bring to light the moral focus of this Life. It first investigates Plutarch’s life and the atmosphere in which he lived to understand what influenced his writing. Chapter One follows with a discussion of the composition of the Lives to understand how they are organized. The insistence on reading each book’s four parts (proem, Life 1, Life 2, synkrisis) to fully appreciate their moral relevance leads to Chapter Two, which dissects the main components of Plutarch’s moral mirror. This provides the necessary background needed for Chapter Three’s case study of Plutarch’s Cimon. Here, I argue that the main moral message contained therein is the importance of generosity and euergetism.
Magical Thinking
Creators: name: Conrod, Heidi Jill
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: painting
surrealism

description: In Magical Thinking, Heidi Conrod explores through the act of painting, the depiction of mental states through the cautious release and withholding of visual, conceptual, and autobiographical cues. Reflecting on the nature of memory and time and the fluid ways in which these seemingly immaterial phenomena interact, the paintings represent multiple visions within one viewing experience; commenting not only on the surface of things, but also on what may lie hidden beneath. The works are best understood through introspection rather than a forced rationale. These paintings are intended to read like a stream, or perhaps a pool of consciousness, where the unconscious is expressed through swirls of imagery with surrealist undertones alluding to the seemingly contradictory conditions of dream and reality. Here fact, fiction, memory and imagination, are intertwined in a non-linear style through a multitude of painterly applications.
ТАБИИЙ ГАЗНИ УГЛЕРОД ДИОКСИДИ ВА ВОДОРОД СУЛФИДЛАРДАН ТОЗАЛАШ УЧУН АДСОРБСИЯ ВА АБСОРБСИЯ УСУЛЛАРИ
Creators: name: Азимов, Салохиддин
Publisher: name: Zenodo
Year: 2024

description: Бу мақолада газларни кислота компонентларидан тозалашда абсорбентларнинг турли-хил янги таклиф қилинган таркибларининг натижалари мавжуд. Бундан ташқари, газ тозалаш қурилмаларида бу абсорбентларнинг коррозион тасири ўрганилди, коррозиён фаолликни камайтириш учун усуллар шакллантирилди ва таклиф қилинди.
Small Trinity
Creators: name: Gollner, Adrian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: conceptual art
explosions
cast sculptures
Trinity

description: I have an interest in transposing elements of sound, time, and motion into other forms. The thesis exhibition, small Trinity, presents my efforts to capture the essence of an explosion as a sculpture. The resulting objects provide viewers with the chance to examine an explosion in a stilled state, but also to consider the enormous powers we humans wield. Comprising the exhibition are three series: Exploded Vases (2014-15), Cast Explosions (2015) and small Trinity (2016). In each, an experimental methodology is applied to tracing, capturing and then casting the shape of small explosions in a manner that is raw and un-manipulated. For the title series, small Trinity (2016), I set a goal of casting an explosion 1/1,000,000th of the power of the first atomic bomb, Trinity (1945). Through a series of successively larger explosions and casts, the goal was achieved and presented as a series of aluminium, concrete and resin sculptures.
Angullozetes Hammer 1967
Creators: name: Ermilov, Sergey G.
name: Shtanchaeva, Umukusum Ya.
name: Subías, Luis S.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Liebstadiidae
Angullozetes

description: Genus Angullozetes Hammer, 1967
 Type species Angullozetes rostratus Hammer, 1967
description: Published as part of Ermilov, Sergey G., Shtanchaeva, Umukusum Ya. & Subías, Luis S., 2018, Contribution to the knowledge of the oribatid mite genus Angullozetes (Acari: Oribatida: Scheloribatidae), pp. 75-81 in Ecologica Montenegrina 18 on page 76, DOI: 10.37828/em.2018.18.5, http://zenodo.org/record/13360218
Additional file 1 of A cluster randomized trial of a Multicomponent Clinical Care Pathway (MCCP) to improve MASLD diagnosis and management in primary care: study protocol
Creators: name: Godwin, Kyler M.
name: Grigoryan, Larissa
name: Thrift, Aaron P.
name: Duong, Hao
name: Kanwal, Fasiha
name: Giardina, Traber
name: Kadiyala, Himabindu
name: Zimolzak, Andrew
name: Patidar, Kavish R.
name: El-Serag, Hashem B.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
Academic Apparel: Examining Gender Inequality and Dress at a Large Canadian University
Creators: name: Annett, Clare
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Gender Inequality
Dress
Clothing
Resistance
Academia

description: Women working in the current Canadian academic system face challenges which their male colleagues do not; one such challenge lies in dressing for work in the university setting. This paper examines the role dress plays in the workplace experiences of female professors at a large Canadian academic research institution. Through on-line and face-to-face focus groups as well as one-on-one interviews with 16 female professors, this study examines how these women decide what to wear to work. Using Goffman’s (1959) symbolic interactionist approach to self-presentation, in combination with Simmel (1957) and Blumer’s (1969) work on fashion, the various meanings attributed to women’s dress are explored. Women’s self-presentation in professional settings is significant, as theorized by Ridgeway’s (1991; 1993; 2011) theories of gender inequality in the workplace. Finally Scott’s (1990) theories of everyday resistance explore the potential for female professors to resist the dominant power structure through their choice of dress and self-presentation at work. The preliminary findings indicate that for those individuals for whom power and authority are not as accessible, dress and self-presentation can be avenues through which these individuals can access this authority and at times some may push back against the unequal power structures which exist in the current Canadian academic system.
The Acquisition of Anaphora Resolution by French-Spanish Bilinguals
Creators: name: Mathieu, Marie-Philip
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: acquisition
anaphora
heritage speakers

description: This study investigates the division of labor between null and overt pronouns in Spanish. The Position of Antecedent Hypothesis (Carminati 2002) posits that null and overt pronouns in null-subject languages differ with respect to antecedent choice in ambiguous constructions. The objectives of this study are to determine i) to what extent native French speakers learning Spanish in adulthood can acquire the same interpretation bias as Spanish speakers, ii) if heritage speakers (HS) of Spanish who grow up in a French environment acquire the same interpretative strategies as native speakers, and iii) if the type of exposure to Spanish influences the extent to which HS and L2 speakers of Spanish acquire the PAH tendencies. Fifty-nine participants (10 HSs, 23 L1 French and 26 L1 Spanish speakers) filled a questionnaire on language background, and completed a written production task and a self-paced judgement task. Our results show that the French and HS’ answers were similar to those of the native speakers, except for the backward anaphora with the matrix subject as the antecedent of the overt pronoun. The French and HSs rated this type of sentence significantly higher than the native Speakers did, which suggests that while French speakers and HS might have acquired the bias for sentences with null pronouns, the bias might not be as strong for the anaphora with overt pronouns. Interestingly, the French speakers tend to be “better” than the HS at rating all sentences like the native speakers.
The Hyperbolic Formal Affine Demazure Algebra
Creators: name: Leclerc, Marc-Antoine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Kac-Moody algebra
Hecke algebra
Formal group law

description: In this thesis, we extend the construction of the formal (affine) Demazure algebra due to Hoffnung, Malagón-López, Savage and Zainoulline in two directions. First, we introduce and study the notion of formal Demazure lattices of a Kac-Moody root system and show that the definitions and properties of the formal (affine) Demazure operators and algebras hold for such lattices. Second, we show that for the hyperbolic formal group law the formal Demazure algebra is isomorphic (after extending the coefficients) to the Hecke algebra.
Additional file 1 of Understanding African American/Black and Latine young and emerging adults living with HIV: a sequential explanatory mixed methods study focused on self-regulatory resources
Creators: name: Wilton, Leo
name: Gwadz, Marya
name: Cleland, Charles M.
name: Campos, Stephanie
name: Munson, Michelle R.
name: Dorsen, Caroline
name: Serrano, Samantha
name: Sherpa, Dawa
name: Saba, Shaddy K.
name: Rosmarin-DeStefano, Corey
name: Filippone, Prema
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1.
SPServer: split-statistical potentials for the analysis of protein structures and protein–protein interactions
Creators: name: Aguirre-Plans, Joaquim
name: Meseguer, Alberto
name: Molina-Fernandez, Ruben
name: Marín-López, Manuel A
name: Jumde, Gaurav
name: Casanova, Kevin
name: Bonet, Jaume
name: Fornes, Oriol
name: Fernandez-Fuentes, Narcis
name: Oliva, Baldo
Publisher: name: BioMed Central
Year: 2021

description: Background: Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein–protein interaction (PPI) structures. In previous works we decomposed the statistical potentials in different terms, named Split-Statistical Potentials, accounting for the type of amino acid pairs, their hydrophobicity, solvent accessibility and type of secondary structure. These potentials have been successfully used to identify near-native structures in protein structure prediction, rank protein docking poses, and predict PPI binding affinities. Results: Here, we present the SPServer, a web server that applies the Split-Statistical Potentials to analyze protein folds and protein interfaces. SPServer provides global scores as well as residue/residue-pair profiles presented as score plots and maps. This level of detail allows users to: (1) identify potentially problematic regions on protein structures; (2) identify disrupting amino acid pairs in protein interfaces; and (3) compare and analyze the quality of tertiary and quaternary structural models. Conclusions: While there are many web servers that provide scoring functions to assess the quality of either protein folds or PPI structures, SPServer integrates both aspects in a unique easy-to-use web server. Moreover, the server permits to locally assess the quality of the structures and interfaces at a residue level and provides tools to compare the local assessment between structures. Server address: https://sbi.upf.edu/spserver/ .
High-order Harmonic Spectroscopy of Cyclic Organic Molecules
Creators: name: Alharbi, Abdullah F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: High-order harmonic generation
Strong-field laser physics
Cyclic organic molecules
Molecular dynamics and structure

description: Understanding the electronic structure and dynamics of cyclic organic molecules is becoming increasingly the subject of investigations from different perspectives due to their unique chemical and physical properties. Since they are largely involved in the biochemistry of living organisms, studies on this class of compounds are also valuable to understand biologically relevant complex systems. Compared to other techniques, high-order harmonic generation (HHG) has been increasingly considered as a powerful spectroscopic tool with Angstrom spatial and attosecond temporal resolutions. This thesis demonstrates that high-order harmonic spectroscopy is capable of providing structural and dynamical information on the electronic systems of representative cyclic organic molecules comprising randomly oriented five-membered or six-membered rings. The first part of this thesis shows that the HHG from these molecules is sensitive to their aromatic character, which results from the de-localized pi electrons, and can potentially be a useful qualitative measure of aromaticity. We show that the advantage of utilizing HHG in this direction stems from the result that only pi molecular orbitals, associated with aromatcity, are responsible for the HHG emission in aromatic systems. The capability of HHG to distinguish cyclic isomers is demonstrated in the case of xylene molecules. Supported by numerical calculations, differences in the isomers are attributed to both tunnel ionization and photorecombination, the first and last steps of HHG. These results enable further HHG-based time-resolved studies of the dynamics associated with isomeric effects that these molecules exhibit. The present work also challenges the well-established prediction that strong field ionization from a molecular orbital is suppressed along nodal planes, where the electron density is zero. In fact, our study shows that considerable tunnel ionization in some cyclic molecules can occur near or along nodal planes. This unusual ionization is reported to have its signature on the quantitative and qualitative dependence of harmonic yield on laser ellipticity. The high symmetry displayed by the cyclic molecule, 1,4 cyclohexadiene, is shown to leave its imprints on the HHG in the form of structural interferences even if the target is randomly oriented. Two-color HHG from this molecule also indicates that hole dynamics could be involved in the generation process. A general study on high harmonic spectroscopy of the Cooper minimum in molecules is also reported. The presence of this minimum could affect the interpretation of harmonics spectra in any molecule containing S or Cl atoms. The molecular environment is shown to influence the position of this spectral modulation.
Koszul Algebras and Koszul Duality
Creators: name: Wu, Gang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Koszul algebras
Quadratic algebras
Koszul duality.

description: In this thesis, we present a detailed exposition of Koszul algebras and Koszul duality. We begin with an overview of the required concepts of graded algebras and homological algebra. We then give a precise treatment of Koszul and quadratic algebras, together with their dualities. We fill in some arguments that are omitted in the literature and work out a number of examples in full detail to illustrate the abstract concepts.