cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Patch-based Carcinoma Detection on Confocal Laser Endomicroscopy Images -- A Cross-Site Robustness Assessment
Creators: name: Aubreville, Marc
name: Goncalves, Miguel
name: Knipfer, Christian
name: Oetter, Nicolai
name: Wuerfl, Tobias
name: Neumann, Helmut
name: Stelzle, Florian
name: Bohr, Christopher
name: Maier, Andreas
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Deep learning technologies such as convolutional neural networks (CNN) provide powerful methods for image recognition and have recently been employed in the field of automated carcinoma detection in confocal laser endomicroscopy (CLE) images. CLE is a (sub-)surface microscopic imaging technique that reaches magnifications of up to 1000x and is thus suitable for in vivo structural tissue analysis. In this work, we aim to evaluate the prospects of a priorly developed deep learning-based algorithm targeted at the identification of oral squamous cell carcinoma with regard to its generalization to further anatomic locations of squamous cell carcinomas in the area of head and neck. We applied the algorithm on images acquired from the vocal fold area of five patients with histologically verified squamous cell carcinoma and presumably healthy control images of the clinically normal contra-lateral vocal cord. We find that the network trained on the oral cavity data reaches an accuracy of 89.45% and an area-under-the-curve (AUC) value of 0.955, when applied on the vocal cords data. Compared to the state of the art, we achieve very similar results, yet with an algorithm that was trained on a completely disjunct data set. Concatenating both data sets yielded further improvements in cross-validation with an accuracy of 90.81% and AUC of 0.970. In this study, for the first time to our knowledge, a deep learning mechanism for the identification of oral carcinomas using CLE Images could be applied to other disciplines in the area of head and neck. This study shows the prospect of the algorithmic approach to generalize well on other malignant entities of the head and neck, regardless of the anatomical location and furthermore in an examiner-independent manner.
description: Erratum: In the previous version, the number of CLE sequences in the vocal folds data set was inadequately reported
Additional file 1: of Stem cells and beta cell replacement therapy: a prospective health technology assessment study
Creators: name: Wallner, Klemens
name: Pedroza, Rene
name: Awotwe, Isaac
name: Piret, James
name: Senior, Peter
name: A. Shapiro
name: McCabe, Christopher
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: 95% Confidence Interval of Results. We report the 95% confidence interval for the costs and benefits of all our scenarios and the ICERs that were calculated from those values. (PDF 60 kb)
ЗАПРЕТ ОПРЕДЕЛЕННЫХ ДЕЙСТВИЙ КАК МЕРА ПРЕСЕЧЕНИЯ
Creators: name: Юлия Владимировна Михайлина
Publisher: name: Вестник экономической безопасности
Year: 2019
Subjects: уголовное судопроизводство
подозреваемый
обвиняемый
мера пресечения
запрет определенных действий
ограничения

description: Рассматривается новая для российского уголовного судопроизводства мера пресечения в виде запрета определенных действий, произведен анализ ее содержания и применения в современных условиях, а также некоторых проблемных вопросов правового регулирования данной меры пресечения.
Additional file 1 of Comparison of epicardial adipose tissue volume quantification between ECG-gated cardiac and non-ECG-gated chest computed tomography scans
Creators: name: Xu, Yuancheng
name: Hrybouski, Stanislau
name: Paterson, D. Ian
name: Li, Zhiyang
name: Lan, Yulong
name: Luo, Lin
name: Shen, Xinping
name: Xu, Lingyu
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mental Health

description: Additional file 1: Table S1. Clinical indications for CT scan in three cohorts
СУДОПРОИЗВОДСТВО ПО УГОЛОВНЫМ ДЕЛАМ О ПРЕСТУПЛЕНИЯХ НЕСОВЕРШЕННОЛЕТНИХ: ВОПРОСЫ ПРОЦЕССУАЛЬНОЙ ДИФФЕРЕНЦИАЦИИ ФОРМ ПРЕДВАРИТЕЛЬНОГО РАССЛЕДОВАНИЯ
Creators: name: Алла Алексеевна Орлова
Publisher: name: Вестник экономической безопасности
Year: 2019
Subjects: производство по делам несовершеннолетних
формы расследования преступлений
процессуальная дифференциация форм расследования
специализация
подследственность
дознание
предварительное следствие
УПК Республики Беларусь

description: Рассмотрены некоторые вопросы, касающиеся особенностей производства по делам несовершеннолетних, затронуты их исторические аспекты. Отражены подходы законодателя и ученых-процессуалистов к определению подследственности уголовных дел о преступлениях несовершеннолетних. Высказаны аргументы, свидетельствующие о необходимости обеспечения должной квалификации должностных лиц, занимающихся расследованием преступлений данной категории. Представлены позиции ученых-процессуалистов на вопросы подследственности и специализации, опыт правового регулирования производства по уголовным делам о преступлениях, совершенных лицами в возрасте до восемнадцати лет, в Республике Беларусь.
Instantaneous and dynamical decoherence
Creators: name: Polonyi, Janos
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Two manifestations of decoherence, called instantaneous and dynamical, are investigated. The former reflects the suppression of the interference between the components of the current state while the latter reflects that within the initial state. These types of decoherence are computed in the case of the Brownian motion and the harmonic and anharmonic oscillators within the semiclassical approximation. A remarkable phenomenon, namely the opposite orientation of the time arrow of the dynamical variables compared to that of the quantum fluctuations generates a double exponential time dependence of the dynamical decoherence in the presence of a harmonic force. For the weakly anharmonic oscillator the dynamical decoherence is found to depend in a singular way on the amount of the anharmonicity.
description: Final version, to appear in J.Phys. A
Quantum simulation of traversable wormhole spacetimes in a Bose-Einstein condensate
Creators: name: Mateos, Jesús
name: Sabín, Carlos
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work we propose a recipe for the quantum simulation of traversable wormhole spacetimes in a Bose-Einstein condensate, both in $1+1D$ and $3+1D$. While in the former case it is enough to modulate the speed of sound along the condensate, in the latter case we need to choose particular coordinates, namely generalized Gullstrand-Painlevé coordinates. For weakly interacting condensates, in both cases we present the spatial dependence of the external magnetic field which is needed for the simulation, and we analyze under which conditions the simulation is possible with the experimental state-of-the-art.
description: 9 pages, 5 figures
Análisis de las habilidades de comunicación y creatividad del alumnado universitario
Creators: name: Elena, De Prada
name: Mareque, Mercedes
Publisher: name: Zenodo
Year: 2022

description: Teniendo en cuenta la importancia otorgada por los empleadores a las destrezas que complementanla capacidad técnica en sus procesos de selección, en los últimos años se han multiplicado losestudios sobre la influencia de las competencias transversales para la inserción laboral. Entre ellas,las competencias comunicativas ocupan el lugar más prominente, siendo demandadas y altamentevaloradas por la mayor parte de los empleadores. Igualmente, la creatividad y su conexión con laresolución de problemas y la innovación es considerada esencial para la empleabilidad.ObjetivosTratamos de explorar si la formación recibida en el contexto universitario se adecúa a lasnecesidades y demandas del mundo laboral actual. Para ello, se tomará como referencia laautopercepción del alumnado y la percepción de sus tutores de las empresas en las que realizan susprácticas extracurriculares sobre las competencias transversales mencionadas: las habilidades decomunicación, la creatividad y la relación entre ambas. Además, se analizará la existencia dediferencias en la autopercepción del alumnado en ambas competencias en función de su sexo.MetodologíaSe utiliza un diseño descriptivo correlacional analizándose 638 expedientes de prácticasextracurriculares realizadas por el alumnado español del Grado en Administración y Dirección deEmpresas del Campus de Ourense de la Universidad de Vigo (la mitad de los expedientes fueroncubiertos por el alumnado y la otra mitad por sus tutores en las empresas). Se valoran las doscompetencias denotadas a través de una escala tipo Likert de 1 a 5, donde 1 indica “mal” y 5“excelente”.ResultadosPor un lado, no se observan diferencias en la autopercepción del alumnado en las dos competenciasanalizadas en función de su sexo. Por otra parte, es de gran relevancia destacar que tanto laautopercepción de los estudiantes como la dada por los tutores es alta en las dos competencias,especialmente en las habilidades de comunicación. Además, los resultados muestran unacorrelación significativa entre ambas competencias, aunque las valoraciones son más bajas si secomparan las puntuaciones otorgadas por el tutor y la autopercepción del alumnado. Cabe destacaren relación con esto último que los tutores valoran las competencias estudiadas de forma máspositiva.ConclusionesLa alta valoración de las destrezas comunicativas dadas por ambos colectivos pone de manifiestoque tanto el alumnado como los empleadores se muestran altamente satisfechos con la formacióncompetencial recibida en el ámbito universitario, destacando la sincronía existente entre laformación recibida y las exigencias del mercado laboral respecto a las competencias comunicativas.La relación entre ambas competencias podría sugerir importantes sinergias entre ellas, por lo queintentar integrar acciones formativas que favorezcan la adquisición de ambas destrezas de formaconjunta y complementaria podría contribuir a que el alumnado desarrollase todo su potencialcomunicativo y creativo.
Αλγόριθμοι μηχανικής μάθησης σε ανομοιογενή δεδομένα: πρόβλεψη της HIV λοίμωξης σε χρήστες ενδοφλέβιων ναρκωτικών της Αθήνας
Creators: name: Ρούσσος, Σωτήριος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Μη ισορροπημένα δεδομένα
subject: Αλγόριθμοι μηχανικής μάθησης
subject: HIV
subject: Χρήστες ενδοφλέβιων ναρκωτικών

description: Η μηχανική μάθηση διανύει μια περίοδο συνεχούς ανάπτυξης. Τα τελευταία χρόνια, όλο και περισσότερο, οι τεχνικές μηχανικής μάθησης χρησιμοποιούνται στην Ιατρική για διάφορα νοσήματα μεταξύ άλλων και των λοιμωδών νοσημάτων, όπως η HIV λοίμωξη. Στις αρχές του 2011 σημειώθηκε επιδημική έκρηξη της HIV λοίμωξης στον πληθυσμό των χρηστών ενδοφλέβιων ναρκωτικών (ΧΕΝ) της Αθήνας. Το Πανεπιστήμιο Αθηνών σε συνεργασία με τον Οργανισμό Κατά των Ναρκωτικών υλοποίησαν το πρόγραμμα ΑΡΙΣΤΟΤΕΛΗΣ, με σκοπό τόσο τον έλεγχο όσο και τη διασύνδεση σε φροντίδα των ΧΕΝ με HIV λοίμωξη. Σκοπός της παρούσας διπλωματικής εργασίας είναι η εύρεση βέλτιστου ταξινομητή για την HIV λοίμωξη σε ΧΕΝ της Αθήνας. Τα δεδομένα που χρησιμοποιήθηκαν προήλθαν από το πρόγραμμα ΑΡΙΣΤΟΤΕΛΗΣ και αφορούσαν στους 3.320 μοναδικούς ΧΕΝ. Επιπροσθέτως, περιείχαν πληροφορίες για τα δημογραφικά χαρακτηριστικά, τη χρήση ουσιών, τις σεξουαλικές συμπεριφορές και τα προγράμματα μείωσης της βλάβης (προγράμματα υποκατάστασης με οπιοειδή, λήψη δωρεάν συρίγγων και άλλα). Εφαρμόστηκαν πέντε αλγόριθμοι ταξινόμησης (Logistic Regression, Random Forest, Support Vector Machines, k-Εγγύτεροι Γείτονες και Decision Tree) χρησιμοποιώντας τα δεδομένα: 1) χωρίς επαναδειγματοληψία, 2) με υποδειγματοληψία, 3) με τυχαία υπερδειγματοληψία, 4) με τεχνική υπερδειγματοληψίας συνθετικής μειονότητας και 5) με προσαρμοστική συνθετική μέθοδο δειγματοληψίας. Οι προαναφερθείσες περιπτώσεις εφαρμόστηκαν στο σύνολο των χαρακτηριστικών, ύστερα από την επιλογή μέρους αυτών καθώς και έπειτα από ανάλυση σε κύριες συνιστώσες. Την καλύτερη επίδοση την είχε ο αλγόριθμος Random forest όταν εφαρμόστηκε σε τυχαία υπερδειγματοληψία. Η ευαισθησία, η ορθότητα καθώς και το AUC score ήταν 0.9929, 0.9805 και 0.9967, αντίστοιχα. Επιλέγοντας 34 από τα 112 χαρακτηριστικά η ευαισθησία, η ορθότητα καθώς και το AUC score ήταν 0.9929, 0.9751 και 0.9967, αντίστοιχα. Συμπερασματικά, το αποτέλεσμα που προέκυψε από τον έλεγχο για την HIV λοίμωξη σε ΧΕΝ της Αθήνας προβλέφθηκε ορθά σε υψηλά ποσοστά, καθιστώντας τους αλγορίθμους ως ένα επιπλέον εργαλείο για την έγκαιρη ανίχνευση των οροθετικών ΧΕΝ, προκειμένου να αποφευχθεί μια νέα επιδημική έκρηξη.
Additional file 2: Figure S2. of Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
Creators: name: D’Avila, Joana
name: Siqueira, Luciana
name: Mazeraud, Aurélien
name: Azevedo, Estefania
name: Foguel, Debora
name: Castro-Faria-Neto, Hugo
name: Sharshar, Tarek
name: Chrétien, Fabrice
name: Bozza, Fernando
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Blood cytokines acutely after the first LPS injection. Blood cytokines were measured 4 h and 7 days after the first LPS injection. A) Blood IL-1β was significantly increased in aged mice 7 days after LPS. B) Blood IL-6 was less upregulated in aged mice 4 h after LPS injection. C) Blood IL-10 levels were not altered acutely. D) Blood IL-4 was significantly decreased in aged mice 7 days after LPS injection. Two-way ANOVA with Bonferroni posttest (*p
Nonclassical States for Non-Hermitian Hamiltonians with the Oscillator Spectrum
Creators: name: Zelaya, K
name: Dey, S.
name: Hussin, V.
name: Rosas-Ortiz, O.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show that the standard techniques that are utilized to study the classical like properties of the pure states for Hermitian systems can be adjusted to investigate the classicality of pure states for non-Hermitian systems. The method is applied to the states of complex-valued potentials that are generated by Darboux transformations and can model both non-PT-symmetric and PT-symmetric oscillators exhibiting real spectra.
description: 32 pages, 23 figures. Rewritten version with new figures and new references
title: Η Γυναίκα σε θέσεις ευθύνης: Συγκριτική μελέτη μεταξύ Ελλάδας και Γαλλίας
title: Women in positions of responsibility: A comparative study of Greece and France
titleType: AlternativeTitle
Creators: name: Στύλιου, Λαμπρινή
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Γυναίκες - απασχόληση
subject: Ηγεσία στις γυναίκες
subject: Γυναίκες - Εξέλιξη
subject: Γυναίκες και θρησκεία
subject: Γυναίκες στελέχη επιχειρήσεων
subject: Γυναίκες - Κοινωνικές συνθήκες
subject: Women - Employment
subject: Leadership in women
subject: Women - Evolution
subject: Women and religion
subject: Women executives
subject: Women - Social conditions
subject: Κοινωνικά στερεότυπα
subject: Φεμινιστικό κίνημα
subject: Θρησκεία
subject: Ανδροκρατούμενη
subject: Ηγεσία
subject: Social stereotypes
subject: Feminist movement
subject: Religion
subject: Male-dominated
subject: Leadership

description: Ο αποκλεισμός των γυναικών από την ανάληψη θέσεων ευθύνης είναι άρρηκτα συνδεδεμένος με τα κυρίαρχα κοινωνικά στερεότυπα σχετικά με το ρόλο, τις ικανότητες και τον προορισμό της γυναίκας. Μέσω της σύγκρισης της Γαλλίας, της κοιτίδας του φεμινιστικού κινήματος που χαρακτηρίζεται από τον απόλυτο διαχωρισμό Εκκλησίας και Πολιτείας, και της Ελλάδας, που χαρακτηρίζεται από την ισχυρή επιρροή της θρησκείας στην κοινωνία, αποδεικνύεται πως η θρησκεία διαδραματίζει κυρίαρχο ρόλο στην αναπαραγωγή των «συντηρητικών» κοινωνικών στερεοτύπων που δυσχεραίνουν την «αναρρίχηση» των γυναικών σε θέσεις ευθύνης. Περαιτέρω, η πρόσληψη των διευθυντικών θέσεων ως κατ’ εξοχήν «ανδροκρατούμενων» είναι υποκειμενική και κατά συνέπεια εσφαλμένη, καθώς προκρίνει έναν μόνο τύπο μορφής ηγεσίας (αυταρχικό) ως ιδανικό για τις διευθυντικές θέσεις, καθώς και διότι υποστηρίζει ότι τα απαραίτητα γνωρίσματα για αυτές (σκληρότητα, αποφασιστικότητα, αυτοπεποίθηση) προσιδιάζουν μονάχα στην ανδρική φύση.
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00217
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Petot, Frédéric
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00217, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Gravity Dual of Two-Dimensional $\mathcal{N} = (2,2)^*$ Supersymmetric Yang-Mills Theory and Integrable Models
Creators: name: Nian, Jun
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The 2D $\mathcal{N}=(2,2)^*$ supersymmetric Yang-Mills theory can be obtained from the 2D $\mathcal{N}=(4,4)$ theory with a twisted mass deformation. In this paper we construct the gravity dual theory of the 2D $\mathcal{N}=(2,2)^*$ supersymmetric $U(N)$ Yang-Mills theory at the large $N$ and large 't Hooft coupling limit using the 5D gauged supergravity. In the UV regime, this construction also provides the gravity dual of the 2D $\mathcal{N}=(2,2)^*$ $U(N)$ topological Yang-Mills-Higgs theory. We propose a triality in the UV regime among integrable model, gauge theory and gravity, and we make some checks of this relation at classical level.
description: 49 pages, 3 figures; V2: typos corrected, more discussions added
Single Equalizer Strategy with no Information Transfer for Conflict Escalation
Creators: name: Engel, Assaf
name: Feigel, Alexander
Publisher: name: arXiv
Year: 2017
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: In an iterated two-person game, for instance prisoner's dilemma or the snowdrift game, there exist strategies that force the payoffs of the opponents to be equal. These equalizer strategies form a subset of the more general zero-determinant strategies that unilaterally set the payoff of an opponent. A challenge in the attempts to understand the role of these strategies in the evolution of animal behavior is the lack of iterations in the fights for mating opportunities or territory control. We show that an arbitrary two-parameter strategy may possess a corresponding equalizer strategy which produces the same result: statistics of the fight outcomes in the contests with mutants are the same for each of these two strategies. Therefore, analyzing only the equalizer strategy space may be sufficient to predict animal behavior if nature, indeed, reduces (marginalizes) complex strategies to equalizer strategy space. The work's main finding is that there is a unique equalizer strategy that predicts fight outcomes without mutual cooperation. The lack of mutual cooperation is a common trait in conflict escalation contests that generally require a clear winner. In addition this unique strategy does not assess information of the opponent's state. The method bypasses the standard analysis of evolutionary stability. The results fit well the observations of combat between male bowl and doily spiders and support an empirical assumption of the war of attrition model that the species use only information regarding their own state during conflict escalation.
description: 14 pages, 4 figures
Immune Mechanisms of Plaque Instability
Creators: name: Gerhardt, Teresa
name: Haghikia, Arash
name: Stapmanns, Philip
name: Leistner, David Manuel
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: plaque erosion
subject: trained immunity
subject: clonal hematopoiesis
subject: infection
subject: COVID-19
subject: stress
subject: gut dysbiosis
subject: atherosclerosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Inflammation crucially drives atherosclerosis from disease initiation to the emergence of clinical complications. Targeting pivotal inflammatory pathways without compromising the host defense could compliment therapy with lipid-lowering agents, anti-hypertensive treatment, and lifestyle interventions to address the substantial residual cardiovascular risk that remains beyond classical risk factor control. Detailed understanding of the intricate immune mechanisms that propel plaque instability and disruption is indispensable for the development of novel therapeutic concepts. In this review, we provide an overview on the role of key immune cells in plaque inception and progression, and discuss recently identified maladaptive immune phenomena that contribute to plaque destabilization, including epigenetically programmed trained immunity in myeloid cells, pathogenic conversion of autoreactive regulatory T-cells and expansion of altered leukocytes due to clonal hematopoiesis. From a more global perspective, the article discusses how systemic crises such as acute mental stress or infection abruptly raise plaque vulnerability and summarizes recent advances in understanding the increased cardiovascular risk associated with COVID-19 disease. Stepping outside the box, we highlight the role of gut dysbiosis in atherosclerosis progression and plaque vulnerability. The emerging differential role of the immune system in plaque rupture and plaque erosion as well as the limitations of animal models in studying plaque disruption are reviewed.
Some universal quadratic sums over the integers
Creators: name: Wu, Hai-Liang
name: Sun, Zhi-Wei
Publisher: name: arXiv
Year: 2017
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11E25, 11E20, 11D85

description: Let $a,b,c,d,e,f\in\mathbb N$ with $a\ge c\ge e>0$, $b\le a$ and $b\equiv a\pmod2$, $d\le c$ and $d\equiv c\pmod2$, $f\le e$ and $f\equiv e\pmod2$. If any nonnegative integer can be written as $x(ax+b)/2+y(cy+d)/2+z(ez+f)/2$ with $x,y,z\in\mathbb Z$, then the ordered tuple $(a,b,c,d,e,f)$ is said to be universal over $\mathbb Z$. Recently, Z.-W. Sun found all candidates for such universal tuples over $\mathbb Z$. In this paper, we use the theory of ternary quadratic forms to show that 44 concrete tuples $(a,b,c,d,e,f)$ in Sun's list of candidates are indeed universal over $\mathbb Z$. For example, we prove the universality of $(16,4,2,0,1,1)$ over $\mathbb Z$ which is related to the form $x^2+y^2+32z^2$.
description: 19 pages, final published version
MOESM2 of Higher cut-off serum procalcitonin level for sepsis diagnosis in metastatic solid tumor patients
Creators: name: Segal Aziz
name: Nelwan, Erni
name: Lugyanti Sukrisman
name: Suhendro Suhendro
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology

description: Additional file 2: Table S1. Diagnostic value of PCT for diagnosing sepsis in metastatic tumor patient; description: describing the performance of PCT as a sepsis biomarker in metastatic tumor patient.
Seven-CpG DNA Methylation Age Determined by Single Nucleotide Primer Extension and Illumina’s Infinium MethylationEPIC Array Provide Highly Comparable Results
Creators: name: Vetter, Valentin Max
name: Kalies, Christian Humberto
name: Sommerer, Yasmine
name: Bertram, Lars
name: Demuth, Ilja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: epigenetic clock
subject: biological age
subject: aging
subject: methylation age
subject: single-nucleotide primer extension assay
subject: Berlin Aging Study II
subject: BASE-II
subject: GendAge study
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: DNA methylation age (DNAm age, epigenetic clock) is a novel and promising biomarker of aging. It is calculated from the methylation fraction of specific cytosine phosphate guanine sites (CpG sites) of genomic DNA. Several groups have proposed epigenetic clock algorithms and these differ mostly regarding the number and location of the CpG sites considered and the method used to assess the methylation status. Most epigenetic clocks are based on a large number of CpGs, e.g. as measured by DNAm microarrays. We have recently evaluated an epigenetic clock based on the methylation fraction of seven CpGs that were determined by methylation-sensitive single nucleotide primer extension (MS-SNuPE). This method is more cost-effective when compared to array-based technologies as only a few CpGs need to be examined. However, there is only little data on the correspondence in epigenetic age estimation using the 7-CpG clock and other algorithms. To bridge this gap, in this study we measured the 7-CpG DNAm age using two methods, via MS-SNuPE and via the MethylationEPIC array, in a sample of 1,058 participants of the Berlin Aging Study II (BASE-II), assessed as part of the GendAge study. On average, participants were 75.6 years old (SD: 3.7, age range: 64.9–90.0, 52.6% female). Agreement between methods was assessed by Bland-Altman plots. DNAm age was highly correlated between methods (Pearson’s r = 0.9) and Bland-Altman plots showed a difference of 3.1 years. DNAm age by the 7-CpG formula was 71.2 years (SD: 6.9 years, SNuPE) and 68.1 years (SD: 6.4 years, EPIC array). The mean of difference in methylation fraction between methods for the seven individual CpG sites was between 0.7 and 13 percent. To allow direct conversion of DNAm age obtained from both methods we developed an adjustment formula with a randomly selected training set of 529 participants using linear regression. After conversion of the Illumina data in a second and independent validation set, the adjusted DNAm age was 71.44 years (SD: 6.1 years, n = 529). In summary, we found the results of DNAm clocks to be highly comparable. Furthermore, we developed an adjustment formula that allows for direct conversion of DNAm age estimates between methods and enables one singular clock to be used in studies that employ either the Illumina or the SNuPE method.
title: UKRN STAR Project
Creators: name: Pennington, Charlotte Rebecca
name: Roesch, Etienne B.
name: Dienes, Zoltan
name: Zou, Yukai
name: Fortunato, Laura
name: DeBruine, Lisa
name: UK Reproducibility Network
Publisher: name: OSF
Year: 2024

description: Documents from the STAR (Sustainable and Transparent Research Data) project.
НЕКОТОРЫЕ ПРОБЛЕМНЫЕ АСПЕКТЫ УЧАСТИЯ АДВОКАТА КАК ЗАЩИТНИКА В УГОЛОВНОМ СУДОПРОИЗВОДСТВЕ
Creators: name: Эльвира Ханифовна Надысева
Publisher: name: Вестник экономической безопасности
Year: 2019
Subjects: предварительное расследование
доследственная проверка
принцип состязательности
участники процесса.

description: Рассматриваются актуальные аспекты участия адвоката как защитника при возбуждении уголовного дела и при расследовании преступлений. Анализируются немаловажные вопросы, непосредственно связанные с реализацией представленных ему УПК РФ и ФЗ «Об адвокатской деятельности и адвокатуре» полномочий, так как несмотря на его процессуальную самостоятельность как участника уголовного судопроизводства не представляется возможным в полной мере определить его процессуальное положение. А также рассматриваются проблемные аспекты, связанные с реализацией принципа состязательности в уголовном процессе при участии адвоката как защитника. Отмечается, что данная проблематика требует своего разрешения, а именно необходимо включить адвоката в число участников уголовного процесса, осуществляющих следствие по делу, уравнивая таким образом положение адвоката со следователем при осуществлении предварительного расследования.
The classification of countable models of set theory
Creators: name: Clemens, John
name: Coskey, Samuel
name: Dworetzky, Samuel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: We study the complexity of the classification problem for countable models of set theory (ZFC). We prove that the classification of arbitrary countable models of ZFC is Borel complete, meaning that it is as complex as it can conceivably be. We then give partial results concerning the classification of countable well-founded models of ZFC.
Roadmap Guided Direct Percutaneous Vertebral Artery Puncture for Mechanical Thrombectomy of Acute Basilar Artery Occlusion: A Technical Case Report and Review of the Literature
Creators: name: Nawabi, Jawed
name: Bohner, Georg
name: Siebert, Eberhard
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: mechanical thrombectomy (MT)
subject: direct vertebral puncture
subject: stroke
subject: large vessel occlusion
subject: bail out
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Access techniques for mechanical thrombectomy normally include percutaneous puncture of the common femoral or, more recently, the radial artery. Although target vessel catheterization may frequently not be devoid of difficulties via both routes, the vast majority of mechanical thrombectomy (MT) cases can be successfully managed. However, in a significant minority of cases, a stable target vessel access cannot be reached resulting in futile recanalization procedures and detrimental outcomes for the patients. As such, in analogy to direct carotid puncture for anterior circulation MT, direct vertebral artery (VA) puncture (DVP) is a direct cervical approach, which can constitute the only feasible access to the posterior circulation in highly selected cases. So far, due to the rarity of DVP, only anecdotal evidence from isolated case reports is available and this approach raises concerns with regard to safety issues, feasibility, and technical realization. We present a case in which bail-out access to the posterior circulation was successfully obtained through a roadmap-guided lateral direct puncture of the V2 segment of the cervical VA and give an overview of technical nuances of published DVP approaches for posterior circulation MT.
ПРОЦЕССУАЛЬНАЯ САМОСТОЯТЕЛЬНОСТЬ СЛЕДОВАТЕЛЯ КАК ОДНА ИЗ СОСТАВЛЯЮЩИХ В ОБЖАЛОВАНИИ РЕШЕНИЙ ПРОКУРОРА
Creators: name: Бислан Еристемович Чич
Publisher: name: Вестник экономической безопасности
Year: 2019
Subjects: следователь
прокурор
обжалование
конфликт
прокурорский надзор
ведомственный контроль

description: В предварительном расследовании процессуальные решения следователя подвергаются оценке, как со стороны руководителя следственного органа, так и со стороны прокуратуры. Следователь обладает достаточными полномочиями по ведению хода следствия, но так ли самостоятельна данная фигура? Имеет ли он право оспорить действия (бездействие) и решения прокурора и отстоять свою точку зрения при расследовании уголовного дела? Процесс обжалования — это взаимодействие определенных законом субъектов — следователя и прокурора, задействованных в нем, участников уголовного судопроизводства, наделенных именно властными полномочиями.
Analysis of Transfer Coordination in Flexible-Route Bus Services
Creators: name: Yang, Tao
Publisher: name: Digital Repository at the University of Maryland
Year: 2023
Subjects: subject: Civil engineering
subject: FOS: Civil engineering
subject: Transportation

description: Urban residents are often confronted with transportation predicaments. The inconvenience caused by the conventional fixed-route bus system has led to excessive reliance on private cars, worsening traffic congestion and air pollution. However, a flexible bus route can provide passengers with a convenient, expedient, cost-effective commuting option. This thesis studies a flexible bus system with Many-to-One (M-1) and Many-to-Many (M-M) demand patterns, comprising multiple rectangular residential zones and a central terminal. The total cost of flexible route bus service is modeled and modified for coordinated and uncoordinated headway conditions. Among them, the demand between each service zone and the central terminal, and the demand among service zones are analyzed to optimize headways in order to minimize total system cost. Finally, the sensitivity analyses are conducted to explore the impact of parameter changes on the results. The comparison of baseline and sensitivity analysis results shows that more benefits can be achieved when coordinating headways under low-demand conditions.
МЕЖДУНАРОДНО-ПРАВОВОЙ ВКЛАД РОССИЙСКОЙ ФЕДЕРАЦИИ В ДЕЛО УКРЕПЛЕНИЯ МЕЖДУНАРОДНОГО СУДА КАК ГЛАВНОГО СУДЕБНОГО ОРГАНА ООН
Creators: name: Валерий Викторович Богатырев
name: Рубен Амаякович Каламкарян
Publisher: name: Вестник экономической безопасности
Year: 2019
Subjects: Российская Федерация
Совет Безопасности ООН
Генеральная Ассанблея ООН
Международный Суд
миропорядок на основе верховенства права

description: Проводится анализ деятельности Международного суда как главного судебного органа ООН. Обозначен вклад Российской Федерации в дело укрепления Международного Суда ООН в миропорядке на основе верховенства права.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 0183r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0183r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0183r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 1: of Genomic prediction using DArT-Seq technology for yellowtail kingfish Seriola lalandi
Creators: name: Nguyen Nguyen
name: H. Premachandra
name: Kilian, Andrzej
name: Knibb, Wayne
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Science Policy

description: Basic statistics of the sequence data used. Descriptive population genetic estimates and statistics of Single Nucleotide Polymorphisms (SNPs). (DOCX 27Â kb)
Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants
Creators: name: Speck, David
name: Kleinau, Gunnar
name: Meininghaus, Mark
name: Erbe, Antje
name: Einfeldt, Alexandra
name: Szczepek, Michal
name: Scheerer, Patrick
name: Pütter, Vera
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: G-protein coupled receptors (GPCR)
subject: leucine-rich repeat containing receptor 7 (LGR7)
subject: relaxin family peptide receptor 1 (RXFP1)
subject: fluorescence-detection size-exclusion chromatography (FSEC)
subject: protein engineering
subject: surface plasmon resonance spectroscopy (SPR)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes. This essential function and association with many diseases or pathological conditions explain why GPCRs are one of the priority targets in medical and pharmacological research, including structure determination. Despite enormous experimental efforts over the last decade, both the expression and purification of these membrane proteins remain elusive. This is attributable to specificities of each GPCR subtype and the finding of necessary experimental in vitro conditions, such as expression in heterologous cell systems or with accessory proteins. One of these specific GPCRs is the leucine-rich repeat domain (LRRD) containing GPCR 7 (LGR7), also termed relaxin family peptide receptor 1 (RXFP1). This receptor is characterized by a large extracellular region of around 400 amino acids constituted by several domains, a rare feature among rhodopsin-like (class A) GPCRs. In the present study, we describe the expression and purification of RXFP1, including the design of various constructs suitable for functional/biophysical studies and structure determination. Based on available sequence information, homology models, and modern biochemical and genetic tools, several receptor variations with different purification tags and fusion proteins were prepared and expressed in Sf9 cells (small-scale), followed by an analytic fluorescence-detection size-exclusion chromatography (F-SEC) to evaluate the constructs. The most promising candidates were expressed and purified on a large-scale, accompanied by ligand binding studies using surface plasmon resonance spectroscopy (SPR) and by determination of signaling capacities. The results may support extended studies on RXFP1 receptor constructs serving as targets for small molecule ligand screening or structural elucidation by protein X-ray crystallography or cryo-electron microscopy.
Short-distance matrix elements for $D^0$-meson mixing for $N_f=2+1$ lattice QCD
Creators: name: Bazavov, A.
name: Bernard, C.
name: Bouchard, C. M.
name: Chang, C. C.
name: DeTar, C.
name: Du, D.
name: El-Khadra, A. X.
name: Freeland, E. D.
name: Gámiz, E.
name: Gottlieb, Steven
name: Heller, U. M.
name: Kronfeld, A. S.
name: Laiho, J.
name: Mackenzie, P. B.
name: Neil, E. T.
name: Simone, J. N.
name: Sugar, R.
name: Toussaint, D.
name: Van de Water, R. S.
name: Zhou, R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate in three-flavor lattice QCD the short-distance hadronic matrix elements of all five $ΔC=2$ four-fermion operators that contribute to neutral $D$-meson mixing both in and beyond the Standard Model. We use the MILC Collaboration's $N_f = 2+1$ lattice gauge-field configurations generated with asqtad-improved staggered sea quarks. We also employ the asqtad action for the valence light quarks and use the clover action with the Fermilab interpretation for the charm quark. We analyze a large set of ensembles with pions as light as $M_π\approx 180$ MeV and lattice spacings as fine as $a\approx 0.045$ fm, thereby enabling good control over the extrapolation to the physical pion mass and continuum limit. We obtain for the matrix elements in the $\overline{\text{MS}}$-NDR scheme using the choice of evanescent operators proposed by Beneke \emph{et al.}, evaluated at 3 GeV, $\langle D^0|\mathcal{O}_i|\bar{D}^0 \rangle = \{0.0805(55)(16), -0.1561(70)(31), 0.0464(31)(9), 0.2747(129)(55), 0.1035(71)(21)\}~\text{GeV}^4$ ($i=1$--5). The errors shown are from statistics and lattice systematics, and the omission of charmed sea quarks, respectively. To illustrate the utility of our matrix-element results, we place bounds on the scale of CP-violating new physics in $D^0$~mixing, finding lower limits of about 10--50$\times 10^3$ TeV for couplings of $\mathrm{O}(1)$. To enable our results to be employed in more sophisticated or model-specific phenomenological studies, we provide the correlations among our matrix-element results. For convenience, we also present numerical results in the other commonly-used scheme of Buras, Misiak, and Urban.
description: Published version, 42 pages, 18 figures
Midwall Fibrosis and Cardiac Mechanics: Rigid Body Rotation Is a Novel Marker of Disease Severity in Pediatric Primary Dilated Cardiomyopathy
Creators: name: Al-Wakeel-Marquard, Nadya
name: Seidel, Franziska
name: Kühnisch, Jirko
name: Kuehne, Titus
name: Berger, Felix
name: Messroghli, Daniel R.
name: Klaassen, Sabine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: midwall fibrosis
subject: cardiac mechanics
subject: rigid body rotation
subject: cardiovascular magnetic resonance
subject: dilated cardiomyopathy
subject: pediatric
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Midwall fibrosis (MWF) detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) predicts adverse outcome in adults with dilated cardiomyopathy (DCM). Its relevance in children and adolescents is relatively unknown. Left ventricular (LV) strain, rotation and twist are important parameters of cardiac function; yet, their role in pediatric heart failure is understudied. This study aimed to evaluate MWF and cardiac mechanics in pediatric DCM. Methods: Patients ≤21 years with primary DCM were prospectively enrolled and underwent standardized CMR including LGE. All participants were categorized according to the presence or absence of MWF (MWF+ vs. MWF–). Cardiac mechanics were assessed using CMR feature tracking. Impaired LV twist with apex and base rotating in the same direction was termed rigid body rotation (RBR). Results: In total, 17 patients (median age 11.2 years) were included. MWF was present in seven patients (41%). Median N-terminal pro brain natriuretic peptide (NT-proBNP) was higher (5,959 vs. 242 pg/ml, p = 0.887) and LV ejection fraction (LVEF) lower (28 vs. 39%, p = 0.536) in MWF+ vs. MWF– patients, yet differences were not statistically significant. MWF+ patients had reduced global longitudinal (GLS), circumferential (GCS) and radial strain (GRS), again without statistical significance (p = 0.713, 0.492 and 1.000, respectively). A relationship between MWF and adverse outcome was not seen (p = 0.637). RBR was more common in MWF+ (67 vs. 50%), and was associated with the occurrence of adverse events (p = 0.041). Patients with RBR more frequently were in higher New York Heart Association classes (p = 0.035), had elevated NT-proBNP levels (p = 0.002) and higher need for catecholamines (p = 0.001). RBR was related to reduced GLS (p = 0.008), GCS (p = 0.031), GRS (p = 0.012), LV twist (p = 0.008), peak apical rotation (p < 0.001), and LVEF (p = 0.001), elevated LV end-diastolic volume (p = 0.023) and LV end-systolic volume (p = 0.003), and lower right ventricular stroke volume (p = 0.023). Conclusions: MWF was common, but failed to predict heart failure. RBR was associated with clinical and biventricular functional signs of heart failure as well as the occurrence of adverse events. Our findings suggest that RBR may predict outcomes and may serve as a novel marker of disease severity in pediatric DCM. Clinical Trial Registration: https://clinicaltrials.gov/, identifier: NCT03572569.
Electron and Nucleon Localization Functions of Oganesson: Approaching the Thomas-Fermi Limit
Creators: name: Jerabek, Paul
name: Schuetrumpf, Bastian
name: Schwerdtfeger, Peter
name: Nazarewicz, Witold
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Fermion localization functions are used to discuss electronic and nucleonic shell structure effects in the superheavy element oganesson, the heaviest element discovered to date. Spin-orbit splitting in the $7p$ electronic shell becomes so large ($\sim$ 10 eV) that Og is expected to show uniform-gas-like behavior in the valence region with a rather large dipole polarizability compared to the lighter rare gas elements. The nucleon localization in Og is also predicted to undergo a transition to the Thomas-Fermi gas behavior in the valence region. This effect, particularly strong for neutrons, is due to the high density of single-particle orbitals.
description: 5 pages, 4 figures
Additional file 1: of Modeling livestock population structure: a geospatial database for Ontario swine farms
Creators: name: Khan, Salah
name: OâSullivan, Terri
name: Poljak, Zvonimir
name: Alsop, Janet
name: Greer, Amy
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Modeling Livestock Population Structure: A Geospatial Database for Ontario Swine Farms. Description of data: Table S1. Data structure and missing data in 2011 agriculture census: pig farm types and number of heads. Figure S1. Frequency of pig farms in Ontarioâ s census consolidated subdivisions: Canadian Agricultural Census 2011. Figure S2. Frequency of pigs in Ontarioâ s census consolidated subdivisions: Canadian Agricultural Census 2011. Figure S3. A map of Canada showing the administrative boundaries of the provinces. Figure S4. An example of relative occupancies of small waterbodies in the 1-km2 spatial grids. Table S2. Land surface covered by the attributes with a suitability score (above zero) supporting swine farms in Ontario. (PDF 336 kb)