cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Text S3 from Differential influences of allometry, phylogeny and environment on the rostral shape diversity of extinct South American notoungulates
Creators: name: Rodrigues, Helder Gomes
name: Cornette, Raphaël
name: Clavel, Julien
name: Cassini, Guillermo
name: Bhart-Anjan S. Bhullar
name: Fernández-Monescillo, Marcos
name: Moreno, Karen
name: Herrel, Anthony
name: Billet, Guillaume
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Supplementary material and methods, and results concerning the alternative models tested
Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design
Creators: name: Goo, Yoon Tae
name: Lee, Sangkil
name: Choi, Ji Yeh
name: Kim, Min Song
name: Sin, Gi Hyeong
name: Hong, Sun Ho
name: Kim, Chang Hyun
name: Song, Seh Hyon
name: Choi, Young Wook
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Computational Biology

description: The lipophilicity of a peptide drug can be considerably increased by hydrophobic ion pairing with amphiphilic counterions for successful incorporation into lipid-based formulations. Herein, to enhance the oral absorption of insulin (INS), a self-microemulsifying drug delivery system (SMEDDS) formulation was developed. Prior to optimization, INS was complexed with sodium n-octadecyl sulfate (SOS) to increase the loading into the SMEDDS. The INS–SOS complex was characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and its dissociation behavior. The SMEDDS was optimized using a D-optimal mixture design with three independent variables including Capmul MCM (X1, 9.31%), Labrasol (X2, 49.77%), and Tetraglycol (X3, 40.92%) and three response variables including droplet size (Y1, 115.2 nm), INS stability (Y2, 46.75%), and INS leakage (Y3, 17.67%). The desirability function was 0.766, indicating excellent agreement between the predicted and experimental values. The stability of INS-SOS against gastrointestinal enzymes was noticeably improved in the SMEDDS, and the majority of INS remained in oil droplets during release. Following oral administration in diabetic rats, the optimized SMEDDS resulted in pharmacological availabilities of 3.23% (50 IU/kg) and 2.13% (100 IU/kg). Thus, the optimized SMEDDS is a good candidate for the practical development of oral delivery of peptide drugs such as INS.
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery
Creators: name: Li, Qi-Rui
name: Xu, Hua-Zhen
name: Xiao, Rong-Cheng
name: Liu, Yan
name: Tang, Jun-Ming
name: Li, Jian
name: Yu, Ting-Ting
name: Liu, Bin
name: Li, Liu-Gen
name: Wang, Mei-Fang
name: Han, Ning
name: Xu, Yong-Hong
name: Wang, Chao
name: Komatsu, Naoki
name: Zhao, Li
name: Peng, Xing-Chun
name: Li, Tong-Fei
name: Chen, Xiao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showed that ND-DOX could be loaded in mouse platelets in a dose-dependent manner with a markedly higher efficiency and capacity than free DOX. ND-DOX-loaded platelets (Plt@ND-DOX) maintained viability and ND-DOX could be stably held in the platelets for at least 4 hr. Next, mouse Lewis lung cancer cells were found to activate Plt@ND-DOX and thereby stimulate cargo unloading of Plt@ND-DOX. The unloaded ND-DOX was taken up by co-cultured cancer cells which consequently exhibited loss of viability, proliferation suppression and apoptosis. In vivo, Plt@ND-DOX displayed significantly prolonged blood circulation time over ND-DOX and DOX in mice, and Lewis tumor grafts demonstrated infiltration, activation and cargo unloading of Plt@ND-DOX in the tumor tissue. Consequently, Plt@ND-DOX effectively reversed the growth of Lewis tumor grafts which exhibited significant inhibition of cell proliferation and apoptosis. Importantly, Plt@ND-DOX displayed a markedly higher therapeutic potency than free DOX but without the severe systemic toxicity associated with DOX. Our findings are concrete proof of platelets as efficient and efficacious carriers for tumor-targeted nano-drug delivery with the following features: 1) large loading capacity and high loading efficiency, 2) good tolerance of cargo drug, 3) stable cargo retention and no cargo unloading in the absence of stimulation, 4) prolonged blood circulation time, and 5) excellent tumor distribution and tumor-activated drug unloading leading to high therapeutic potency and few adverse effects. Platelets hold great potential as efficient and efficacious carriers for tumor-targeted nano-drug delivery.
Moment fluid equations for ions in weakly-ionized plasma
Creators: name: Semenov, I. L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: A new one-dimensional fluid model for ions in weakly-ionized plasma is proposed. The model differs from the existing ones in two aspects. First, a more accurate approximation of the collision terms in the fluid equations is suggested. For this purpose, the results obtained using the Monte-Carlo kinetic model of the ion swarm experiments are considered. Second, the ion energy equation is taken into account. The fluid equations are closed using a simple model of the ion velocity distribution function. The accuracy of the fluid model is examined by comparing with the results of particle-in-cell/Monte Carlo simulations. In particular, several test problems are considered using a parallel plate model of the capacitively coupled radio-frequency discharge. It is shown that the results obtained using the proposed fluid model are in good agreement with those obtained from the simulations over a wide range of discharge conditions. An approximation of the ion velocity distribution function for the problem under consideration is also discussed.
Combination of chemotherapy and immune checkpoint therapy by the immunoconjugates-based nanocomplexes synergistically improves therapeutic efficacy in SCLC
Creators: name: Tao, Zhang
name: Kuai, Xingwang
name: Wang, Guangwei
name: Liu, Sanfeng
name: Liu, Kai
name: Zhang, Heng
name: Xia, Shujing
name: Zhu, Hua
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Although the etoposide and carboplatin (EP) combination strategy has been the first-line chemotherapy, patients with extensive-stage disease small-cell lung cancer (SCLC) still have poor survival outcomes. Our retrospective analysis revealed that 46 patients with SCLC only achieved medium overall survival (OS) of 11.6 months after treated by EP. Recently, it was demonstrated that combination therapy of PD1/PD-L1 immune checkpoint blocker and EP could significantly improve the OS of SCLC patients. However, the serious treatment-related toxicity leaded to a high rate of treatment-discontinuation or even death. In the present study, we have developed a novel TPP1-conjugated nanocomplex, abbreviated as TPP1NP-EP, which was co-loaded with carboplatin (CBP) and etoposide (VP16). The TPP1 was a PD-L1 targeting peptide and conjugated on the surface of nanocomplex by a matrix metalloproteinase (MMP-2/9)-cleavable peptide linker sequence PLGLAG. For dual-loading of CBP and VP16, the CBP was chemically conjugated with poly(ethylene glycol) (PEG)–poly(caprolactone) (PCL) by pH-sensitive hydrazone bond and the VP16 was physically encapsulated by emulsion-solvent evaporation method. In vitro and in vivo experiments demonstrated an excellent anti-tumor effect of TPP1NP-EP on SCLC and improved safety. In conclusion, the present study has provided a promising strategy for treatment of malignant SCLC.
Additional file 1 of Multivariate meta-analysis of multiple outcomes: characteristics and predictors of borrowing of strength from Cochrane reviews
Creators: name: Hattle, Miriam
name: Burke, Danielle L.
name: Trikalinos, Thomas
name: Schmid, Christopher H.
name: Chen, Yong
name: Jackson, Dan
name: Riley, Richard D.
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Cell Biology
Mathematical Sciences not elsewhere classified
Science Policy

description: Additional file 1.
Text S2 from Differential influences of allometry, phylogeny and environment on the rostral shape diversity of extinct South American notoungulates
Creators: name: Rodrigues, Helder Gomes
name: Cornette, Raphaël
name: Clavel, Julien
name: Cassini, Guillermo
name: Bhart-Anjan S. Bhullar
name: Fernández-Monescillo, Marcos
name: Moreno, Karen
name: Herrel, Anthony
name: Billet, Guillaume
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Details concerning the different retro-deformation stages of Campanorco inauguralis MLP79-IV-16-1
Resonance capture at arbitrary inclination: II. Effect of the radial drift rate
Creators: name: Namouni, Fathi
name: Morais, Maria Helena Moreira
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The effect of radial drift rate on mean motion resonance capture is studied for prograde, polar and retrograde orbits. We employ the numerical framework of our earlier exploration of resonance capture at arbitrary inclination. Randomly constructed samples of massless particles are set to migrate radially from outside the orbit of a Jupiter-mass planet at different drift rates totalling more than $1.6\times 10^6$ numerical simulations. Slower drift rates reduce overall capture probability especially for prograde orbits and enhance capture at specific initial inclinations of high order resonances such as the outer 1:5, 1:4, 1:3, 2:5, 3:7 and 5:7. Global capture is reduced with increasing eccentricity at all inclinations as high order resonances capture more particles that are subsequently lost by disruptive close encounters with the planet. The relative efficiency of retrograde resonances at long-lived capture with respect to prograde resonances is explained by the reduced effect of planet encounters as such events occur with a shorter duration and a higher relative velocity for retrograde motion. Capture in the coorbital 1:1 resonance is marginally affected by the radial drift rate except for nearly coplanar retrograde eccentric orbits whose capture likelihood is increased significantly with slower drift rates. An unexpected finding is the presence of a dynamical corridor for capture in high order inner prograde resonances with initial inclinations in the range [50$^\circ$,80$^\circ$] especially at the inner 5:2 resonance whose capture likelihood peaks at 80% to 90% depending on initial eccentricity.
description: 15 pages, 9 figures. To appear in Monthly Notices of the Royal Astronomical Society
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling
Creators: name: Fereig, Salma A.
name: El-Zaafarany, Ghada M.
name: Arafa, Mona G.
name: Abdel-Mottaleb, Mona M. A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Gold nanoparticles are a promising drug delivery system for treatment of inflammatory skin conditions, including psoriasis, due to their small size and anti-inflammatory properties. The aim of this study was to conjugate gold nanoparticles with anti-psoriatic formulations that previously showed successful results in the treatment of psoriasis (tacrolimus-loaded chitosan nanoparticles and lecithin–chitosan nanoparticles) by virtue of their surface charges, then examine whether the hybridization with gold nanoparticles would enhance the anti-psoriatic efficacy in vivo. Successful formation of gold nanoparticles was examined by elemental mapping and selected area electron diffraction (SAED). Hybrid conjugates were examined in terms of particle size and zeta potential by dynamic light scattering (DLS). Morphological features were captured by transmission electron microscope (TEM) and X-ray diffraction (XRD) analysis was conducted, as well. All characterization was conducted for the conjugated nanoparticles and compared with their bare counterparts. The in vivo results on imiquimod (IMQ)-induced mouse model showed promising anti-psoriatic effects upon application of gold conjugated tacrolimus-loaded lecithin–chitosan hybrid nanoparticles with a significant difference from the bare hybrid nanoparticles in some of the inflammatory markers. The anti-inflammatory effect of the gold conjugate was also evident by a lower spleen to body weight ratio and a better histopathological skin condition compared to other tested formulations.
Two-exponential models of gene expression patterns for noisy experimental data
Creators: name: Alexandrov, Theodore
name: Golyandina, Nina
name: Holloway, David
name: Shlemov, Alex
name: Spirov, Alexander
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Applications (stat.AP)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Motivation: Spatial pattern formation of the primary anterior-posterior morphogenetic gradient of the transcription factor Bicoid (Bcd) has been studied experimentally and computationally for many years. Bcd specifies positional information for the downstream segmentation genes, affecting the fly body plan. More recently, a number of researchers have focused on the patterning dynamics of the underlying bcd mRNA gradient, which is translated into Bcd protein. New, more accurate techniques for visualizing bcd mRNA need to be combined with quantitative signal extraction techniques to reconstruct the bcd mRNA distribution. Results: Here, we present a robust technique for quantifying gradients with a two-exponential model. This approach: 1) has natural, biologically relevant parameters; and 2) is invariant to linear transformations of the data which can arise due to variation in experimental conditions (e.g. microscope settings, non-specific background signal). This allows us to quantify bcd mRNA gradient variability from embryo to embryo (important for studying the robustness of developmental regulatory networks); sort out atypical gradients; and classify embryos to developmental stage by quantitative gradient parameters.
Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels
Creators: name: Zarinwall, Ajmal
name: Maurer, Viktor
name: Pierick, Jennifer
name: Oldhues, Victor Marcus
name: Porsiel, Julian Cedric
name: Finke, Jan Henrik
name: Garnweitner, Georg
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Promising active pharmaceutical ingredients (APIs) often exhibit poor aqueous solubility and thus a low bioavailability that substantially limits their pharmaceutical application. Hence, efficient formulations are required for an effective translation into highly efficient drug products. One strategy is the preservation of an amorphous state of the API within a carrier matrix, which leads to enhanced dissolution. In this work, mesoporous silica aerogels (SA) were utilized as a carrier matrix for the amorphization of the poorly water-soluble model drug ibuprofen. Loading of tailored SA was performed post-synthetically and solvent-free, either by co-milling or via the melting method. Thorough analyses of these processes demonstrated the influence of macrostructural changes during the drying and grinding process on the microstructural properties of the SA. Furthermore, interfacial SA-drug interaction properties were selectively tuned by attaching terminal hydrophilic amino- or hydrophobic methyl groups to the surface of the gel. We demonstrate that not only the chemical surface properties of the SA, but also formulation-related parameters, such as the carrier-to-drug ratio, as well as process-related parameters, such as the drug loading method, decisively influence the ibuprofen adsorption efficiency. In addition, the drug-loaded SA formulations exhibited a remarkable physical stability over a period of 6 months. Furthermore, the release behavior is shown to change considerably with different surface properties of the SA matrix. Hence, the reported results demonstrate that utilizing specifically processed and modified SA offers a compelling technique for enhancement of the bioavailability of poorly-water soluble APIs and a versatile adjustment of their release profile.
Microchannel-embedded implantable device with fibrosis suppression for prolonged controlled drug delivery
Creators: name: Ji, Han Bi
name: Hong, Jae Young
name: Kim, Cho Rim
name: Min, Chang Hee
name: Han, Jae Hoon
name: Kim, Min Ji
name: Kim, Se-Na
name: Lee, Cheol
name: Bin Choy, Young
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: For the prolonged, controlled delivery of systemic drugs, we propose an implantable drug-delivery chip (DDC) embedded with pairs of a microchannel and drug-reservoir serving as a drug diffusion barrier and depot, respectively. We pursued a DDC for dual drugs: a main-purpose drug, diclofenac (DF), for systemic exposure, and an antifibrotic drug, tranilast (TR), for local delivery. Thus, the problematic fibrotic tissue formation around the implanted device could be diminished, thereby less hindrance in systemic exposure of DF released from the DDC. First, we separately prepared DDCs for DF or TR delivery, and sought to find a proper microchannel length for a rapid onset and sustained pattern of drug release, as well as the required drug dose. Then, two distinct DDCs for DF and TR delivery, respectively, were assembled to produce a Dual_DDC for the concurrent delivery of DF and TR. When the Dual_DDC was implanted in living rats, the DF concentration in blood plasma did not drop significantly in the later periods after implantation relative to that in the early periods before fibrotic tissue formation. When the Dual_DDC was implanted without TR, there was a significant decrease in the blood plasma DF concentration as the time elapsed after implantation. Biopsied tissues around the Dual_DDC exhibited a significant decrease in the fibrotic capsule thickness and collagen density relative to the Dual_DDC without TR, owing to the effect of the local, sustained release of the TR.
Building Resilience: The Emergence of Refugee-Led Education Initiatives in Indonesia to Address Service Gaps Faced in Protracted Transit
Creators: name: Brown, Thomas Mitchell
Publisher: name: Austrian Journal of South-East Asian Studies
Year: 2018

description: Following recent changes in Australian immigration policy, and in the context of an increasing global refugee crisis, more than 14,000 asylum seekers and refugees now live in protracted transit in Indonesia, spending years awaiting resettlement through the United Nations High Commissioner for Refugees to a third country. Despite the increasing length of time refugees are spending in Indonesia, they live in a state of limbo, prohibited from working and having limited access to education. Although refugees in such situations are commonly perceived to be passive agents resigned to helplessness and in need of outside assistance, refugee communities are challenging this notion by working together to independently address their collective needs. As such, the question emerges: How and to what extent do refugees self-organize to overcome barriers in access to basic services and rights while living in protracted transit in Indonesia? In Cisarua, a small town in West Java, the Hazara refugee community has responded by banding together and mobilizing their skills and experiences to independently provide sorely-needed education services for their own community. This article documents this example of refugee resilience and self-reliance, tracing the emergence of these refugee-led education initiatives, detailing their form, function, and benefits to the community, and analyzing the contextual factors that drove their emergence and proliferation in Cisarua.
description: Austrian Journal of South-East Asian Studies, Vol 11 No 2 (2018): Forced Migration
REVISITANDO "EDUCAÇÃO MATEMÁTICA: DA TEORIA A PRÁTICA" DE UBIRATAN D'AMBROSIO
Creators: name: Avaetê de Lunetta e Rodrigues Guerra
Publisher: name: Zenodo
Year: 2024

description: A obra “Educação matemática: Da teoria a prática”, é uma leitura essencial para todos os profissionais e estudantes envolvidos no campo da educação matemática. Neste livro, D'ambrosio apresenta uma análise profunda e abrangente sobre a importância da educação matemática e sua relação com a teoria e a prática. O autor apresenta uma visão crítica e abrangente sobre o ensino da matemática, destacando a importância de uma abordagem contextualizada, inclusiva e tecnologicamente integrada. Com exemplos práticos e orientações para a sala de aula, D'ambrosio oferece um guia valioso para aprimorar a prática educativa e promover uma educação matemática de qualidade.
The TeV supernova remnant shell HESS J1731-347 and its surroundings
Creators: name: Capasso, M.
name: Condon, B.
name: Coffaro, M.
name: Cui, Y.
name: Gottschall, D.
name: Klochkov, D.
name: Marandon, V.
name: Maxted, N.
name: Pühlhofer, G.
name: Rowell, G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: HESS J1731-347 is a shell-type supernova remnant emitting both TeV gamma rays and non-thermal X-ray photons, spatially coincident with the radio SNR G353.6-0.7. Hadronic and leptonic scenarios (or a blend of both) are discussed in the literature to explain the TeV emission from the object. In 2011, a $γ$-ray excess was also found in the neighborhood of the source (HESS J1729-345). Here we present results of an updated analysis obtained with the meanwhile available additional H.E.S.S. data. Beyond HESS J1731-347, the analysis reveals the morphology of the emission of the adjacent TeV source HESS J1729-345 and the emission in between the two sources in greater detail. The results permit us to correlate the TeV emission outside of the SNR with molecular gas tracers, and to confront the data with scenarios in which the TeV emission outside the SNR is produced by escaping cosmic rays.
description: 4 pages, 4 figures. Contribution to the 6th International Symposium on High Energy Gamma-Ray Astronomy (Gamma2016), July 11-15, 2016, Heidelberg, Germany. To be published in the AIP Conference Proceedings
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization
Creators: name: Bi, Qiu-Chen
name: Tang, Jian-Jun
name: Zhao, Jun
name: Lv, Yang-Feng
name: Deng, Zhi-Qiang
name: Chen, Hong
name: Xu, Yu-Hua
name: Xie, Chuan-Sheng
name: Liang, Qing-Rong
name: Luo, Rong-Guang
name: Tang, Qun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Cell Biology
Pharmacology
Biotechnology
Developmental Biology
Cancer

description: Arsenic trioxide (As2O3, ATO) has limited therapeutic benefit to treat solid tumors, whether used alone or in combination. Nanoscale drug delivery vehicles have great potential to overcome the limitation of the utility of ATO by rapid renal clearance and dose-limiting toxicity. Polymeric materials ranging from gelatin foam to synthetic polymers such as poly(vinyl alcohol) were developed for vascular embolic or chemoembolic applications. Recently, we have introduced sevelamer, an oral phosphate binder, as a new polymeric embolic for vascular interventional therapy. In this paper, sevelamer arsenite nanoparticle with a polygonal shape and a size of 50–300 nm, synthesized by anionic exchange from sevelamer chloride, was developed as a Pi-responsive bifunctional drug carrier and embolic agent for chemoembolization therapy. At the same arsenic dosage, sevelamer arsenite-induced severer tumor necrosis than ATO on the VX2 cancer model. In vitro tests evidenced that Pi deprivation by sevelamer could enhance ATO’s anticancer effect. The results showed that ATO in Pi starvation reduced cell viability, induced more apoptosis, and diminished the mitochondrial membrane potential (Δψm) of cells since Pi starvation helps ATO to further down-regulate Bcl-2 expression, up-regulate Bax expression, enhance the activation of caspase-3 and increase the release of cytochrome c, and the production of excessive reactive oxygen species (ROS). Sevelamer arsenite not only plays a Pi-activated nano-drug delivery system but also integrated anticancer drug with embolic for interventional therapy. Therefore, our results presented a new administration route of ATO as well as an alternative chemoembolization therapy.
Supplemental Figures from Resource-driven changes to host population stability alter the evolution of virulence and transmission
Creators: name: Hite, Jessica L.
name: Cressler, Clayton E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: What drives the evolution of parasite life-history traits? Recent studies suggest that feedbacks between within- and between-host processes can provide key insight into both disease dynamics and parasite evolution. Still, it remains difficult to understand how to pinpoint the critical factors connecting these cross-scale feedbacks, particularly under non-equilibrium conditions; many natural host populations inherently fluctuate and parasites themselves can strongly alter the stability of host populations. Here, we develop a general model framework that mechanistically links resources to parasite evolution across a gradient of stable and unstable conditions. First, we dynamically link resources and between-host (host density, stability, transmission) processes to virulence evolution. Then, we consider a ‘nested’ model where population-level processes (transmission and virulence) depend on resource-driven changes to individual-level (within-host) processes (energetics, immune function, parasite production). Contrary to ‘non-nested’ model predictions, the nested model reveals complex effects of host population dynamics on parasite evolution, including regions of evolutionary bistability; evolution can push parasites towards strongly or weakly stabilizing strategies. This bistability results from dynamic feedbacks between resource-driven changes to host density, host immune function and parasite production. Together, these results highlight how cross-scale feedbacks can provide key insights into the structuring role of parasites and parasite evolution.This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.
Histopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in bleomycin-induced acute and chronic lung injury in rats
Creators: name: Albanawany, Neama M.
name: Samy, Doaa M.
name: Zahran, Noha
name: El-Moslemany, Riham M.
name: Elsawy, Shefaa Mf.
name: Nazel, Maha W. Abou
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Acute lung injury (ALI) is a life-threatening illness which may progress to chronic pulmonary fibrosis (CPF). Resveratrol (RSV), a natural polyphenol, is known to exert several pharmacological effects on lung injury. However, its physicochemical properties and pharmacokinetic profile limit its clinical applications. In this study, RSV was loaded into lipid nanocapsules (LNCs) aiming to overcome these limitations. RSV-LNCs were prepared by phase inversion method and showed small uniform particle size (∼55 nm, PdI 0.04) with high entrapment efficiency >99%. The efficacy of RSV-LNCs in the prophylaxis against ALI and treatment of CPF was investigated in bleomycin-induced lung injury. For assessment of ALI, rats were administered a single oral dose of RSV (10 mg/kg) either free or as RSV-LNCs 4 h before bleomycin and euthanized 3 days later. For CPF, treatments in the same dose were given daily from days 10–20 after bleomycin and rats were euthanized on day-21. Results showed enhanced beneficial role for RSV-LNCs, compared to RSV, in the prevention of ALI as demonstrated by preservation of pulmonary microscopic and ultrastructural architecture and improvement of pulmonary functions. Analysis of BALF revealed reduction in oxidative stress markers, IL-6 level, leukocytosis and neutrophilia. iNOS and c-caspase 3 immunohistochemical expression and CD68+ cells immunofluorescence were inhibited. However, RSV-LNCs failed to show any improvement in oxidative stress, chronic inflammation, apoptosis and collagen deposition in CPF. In conclusion, RSV-LNCs are promising nanoplatforms for mitigating ALI detrimental effects. Future research investigating higher doses and longer durations of treatment is recommended to evaluate RSV-LNCs anti-fibrotic potential in CPF.
Introducing the anatomy of disciplinary discernment: an example from astronomy
Creators: name: Eriksson, Urban
name: Linder, Cedric
name: Airey, John
name: Redfors, Andreas
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: Education is increasingly being framed by a competence mindset; the value of knowledge lies much more in competence performativity and innovation than in simply knowing. Reaching such competency in areas such as astronomy and physics has long been known to be challenging. The movement from everyday conceptions of the world around us to a disciplinary interpretation is fraught with pitfalls and problems. Thus, what underpins the characteristics of the disciplinary trajectory to competence becomes an important educational consideration. In this article we report on a study involving what students and lecturers discern from the same disciplinary semiotic resource. We use this to propose an Anatomy of Disciplinary Discernment (ADD), a hierarchy of what is focused on and how it is interpreted in an appropriate, disciplinary manner, as an overarching fundamental aspect of disciplinary learning. Students and lecturers in astronomy and physics were asked to describe what they could discern from a video simulation of travel through our Galaxy and beyond. 137 people from nine countries participated. The descriptions were analysed using a hermeneutic interpretive study approach. The analysis resulted in the formulation of five qualitatively different categories of discernment; the ADD, reflecting a view of participants' competence levels. The ADD reveals four increasing levels of disciplinary discernment: Identification, Explanation, Appreciation, and Evaluation. This facilitates the identification of a clear relationship between educational level and the level of disciplinary discernment. The analytical outcomes of the study suggest how teachers of science, after using the ADD to assess the students disciplinary knowledge, may attain new insights into how to create more effective learning environments by explicitly crafting their teaching to support the crossing of boundaries in the ADD model.
description: 16 pages
An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy
Creators: name: Zeng, Huating
name: Li, Xiaoqi
name: Liu, Yuping
name: Li, Xia
name: Qu, Ding
name: Chen, Yan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Space Science
Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Combinational icaritin (IC) and coix seed oil (CSO) holds promising potential in the treatment of hepatocellular carcinoma. However, traditional cocktail therapy is facing difficulties to optimize the synergistic antitumor efficacy due to the asynchronous pharmacokinetics. Therefore, we developed an icaritin-loaded microemulsion based on coix seed oil (IC-MEs) for improved pharmacokinetics and enhanced antitumor efficacy. The preparation technology of IC-MEs was optimized by the Box–Behnken design and the pharmaceutical properties were characterized in detail. IC-MEs show synergistic antiproliferation against HepG2 cells compared with monotherapy. The mechanism is associated with stronger apoptosis induction via enhancing caspases-3 activity. IC-MEs significantly improve the bioavailability of IC due to the encapsulation of coix oil-based microemulsion and also obtain the desired liver accumulation and elimination. More importantly, IC-MEs exhibit the overwhelming antitumor ability among all of the treatments on the HepG2 xenograft-bearing mice. This study verifies the feasibility of using coix oil-based microemulsion to improve the antitumor effect of water-insoluble components.
Emission enhancement with epitaxially integrated plasmonic materials and Auger recombination mediation through strain
Creators: name: Briggs, Andrew Frederick
Publisher: name: The University of Texas at Austin
Year: 2021
Subjects: Mid-infrared
MBE

description: There exists signiﬁcant interest in the demonstration and development of alternative mid-infrared emitters, with future applications for thermal scene projection, low-cost infrared sensing, and possible long-wavelength quantum communication applications. We propose two approaches for enhancing mid-infrared emitters. The first is an investigation into the parasitic Auger recombination in mid-infrared type-I laser material. Below 3 µm type-I diode lasers have comparable performance to their QCL and ICL counterparts. As bandgap narrows and emission wavelength moves further into the mid-infrared, Auger recombination begins to severely diminish device performance. Improvements in laser performance have been reported in highly strained GaInAsSb active regions, presumed to be due to a suppression in Auger recombination. We focused on differentiating between the effects changes in alloy composition and changes in external strain have on Auger recombination in GaInAsSb and found that within the non-degenerate regime a suppression of Auger recombination was closely linked to the active region chemical composition rather than the strain. The second approach is to enhance type-II mid-infrared emitters by pairing them with monolithically integrated plasmonic materials in an all-epitaxial approach. Remarkable systems have been reported recently using polylithic integration of semiconductor optoelectronic devices and plasmonic materials. Molecular beam epitaxy allows for the all-epitaxial integration of low-loss “designer metals” and relatively inefficient mid-infrared emitters. Coupling plasmonic materials and emitters not only offers a chance to investigate fundamental light-matter interactions but also offers an opportunity to engineer a new class of increase efficiency mid-infrared electrically injected emitters. Through careful optimization of device design, growth, and fabrication we have been able to seamlessly integrates designer plasmonic materials into a quantum dot light-emitting diode. The cavity-enhanced device shows a 5.6 x enhancement over an otherwise identical control sample. Further optimization to overlap the emitter and plasmonic material will lead to an all-epitaxial plasmonically enhanced light-emitting diode. Our approaches include the incorporation of an engineered plasmonic cavity, AlInAsSb digital alloy barrier, and well-overlapped plasmonic n⁺⁺InAs and n⁺⁺InAs/InAsSb T2SL material with type-II quantum emitters to produce both a resonant cavity and plasmonic responses.
Finding Evolutionarily Stable Life History Strategies from Resource-driven changes to host population stability alter the evolution of virulence and transmission
Creators: name: Hite, Jessica L.
name: Cressler, Clayton E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Mathematical details of the adaptive dynamics analysis of the non-nested and nested models.
Some Aspects of Electron Dynamics in Electron Cyclotron Resonance Ion Sources
Creators: name: Mironov, V.
name: Bogomolov, S.
name: Bondarchenko, A.
name: Efremov, A.
name: Loginov, V.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Electron dynamics in Electron Cyclotron Resonance Ion Source is numerically simulated by using Particle-In-Cell code combined with simulations of the ion dynamics. Mean electron energies are found to be around 70 keV close to values that are derived from spectra of X-ray emission out of the source. Electron life time is defined by losses of low-energy electrons created in ionizing collisions; the losses are regulated by electron heating rate, which depends on magnitude of the microwave electric field. Changes in ion confinement with variations in the microwave electric field and gas flow are simulated. Influence of electron dynamics on the afterglow and two-frequency heating effects is discussed.
Random evolutionary dynamics driven by fitness and house-of-cards mutations. Sampling formulae
Creators: name: Huillet, Thierry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We first revisit the multi-allelic mutation-fitness balance problem, especially when mutations obey a house of cards condition, where the discrete-time deterministic evolutionary dynamics of the allelic frequencies derives from a Shahshahani potential. We then consider multi-allelic Wright-Fisher stochastic models whose deviation to neutrality is from the Shahsha-hani mutation/selection potential. We next focus on the weak selection, weak mutation cases and, making use of a Gamma calculus, we compute the normalizing partition functions of the invariant probability densities appearing in their Wright-Fisher diffusive approximations. Using these results, Generalized Ewens sampling formulae (ESF) from the equilibrium distributions are derived. We start treating the ESF in the mixed mutation/selection potential case and then we restrict ourselves to the ESF in the simpler house-of-cards mutations only situation. We also address some issues concerning sampling problems from infinitely-many alleles weak limits.
description: \`a paraitre: Journal of Statistical Physics
title: 02_1540
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Establishing consensus on lifestyle recommendations and behaviour change strategies to promote brain health-focussed care for multiple sclerosis: A modified e-Delphi study
Creators: name: Wills, Olivia
name: Brischetto, D
name: Zoszak, Karen
name: Allogmanny, Shoroog Mohammad A
name: McMahon, Anne-Therese
name: Haartsen, J
name: Probst, Yasmine
Publisher: name: University of Wollongong
Year: 2025
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine

description: Introduction: Brain health is a global priority for multiple sclerosis (MS) care. This study aimed to establish consensus on internationally applicable lifestyle recommendations and behaviour change strategies to promote lifelong brain health for people living with MS. Methods: A three-round, modified, e-Delphi survey was conducted. Lifestyle recommendations and behaviour change strategies were generated based on a review of the published literature, qualitative interviews, and expert feedback, respectively. Results: Sixty-nine experts participated, with a final response rate of 75 %. Experts were predominantly female (n = 50, 72 %), 30 to 59 years of age (n = 54, 78 %) and worked in an academic institution (n = 21, 50 %). A majority (n = 16, 80 %) of experts with lived experience had a relapsing-remitting phenotype. Starting with 15 lifestyle recommendations, we iteratively identified new recommendations and combined existing ones, achieving consensus on 17 lifestyle recommendations among experts from healthcare, academia, research and advocacy; 16 among experts with lived experience, and 14 behaviour change strategies, presented as separate frameworks. Conclusions: An e-Delphi process has established lifestyle recommendations and identified behaviour change strategies to promote brain health-focussed care for MS. Reliance on these frameworks with detailed management recommendations may help to establish consistency in lifestyle behaviour management of MS, between and within healthcare systems.
Parsec-scale Variations in the 7Li/6Li Isotope Ratio Toward IC 348 and the Per OB 2 Association
Creators: name: Knauth, D. C.
name: Taylor, C. J.
name: Ritchey, A. M.
name: Federman, S. R.
name: Lambert, D. L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Measurements of the lithium isotopic ratio in the diffuse interstellar medium from high-resolution spectra of the LiI λ6708 resonance doublet have now been reported for a number of lines of sight. The majority of the results for the 7Li/6Li ratio are similar to the Solar System ratio of 12.2 but the line of sight toward o Per, a star near the star-forming region IC 348, gave a ratio of about 2, the expected value for gas exposed to spallation and fusion reactions driven by cosmic rays. To examine the association of IC 348 with cosmic rays more closely, we measured the lithium isotopic ratio for lines of sight to three stars within a few parsecs of o Per. One star, HD 281159, has 7Li/6Li ~ 2 confirming production by cosmic rays. The lithium isotopic ratio toward o Per and HD 281159 together with published analyses of the chemistry of interstellar diatomic molecules suggest that the superbubble surrounding IC 348 is the source of the cosmic rays.
description: 19 pages, 1 figure and two tables
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 853
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 853, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 853, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019