cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Serum interleukin-4 is elevated in clinical drug-induced liver injury
Creators: name: Liu, MN
name: Au, M.
name: Bishara, M.
name: Worland, T.
name: Con, D.
name: Chew, S.
name: McNiece, A.
name: Gronbaek, H.
name: Sluka, P.
name: Nicoll, AJ
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Drug-induced liver injury (DILI) remains a challenging diagnosis due to an absence of specific biomarkers. DILI due to volatile anaesthetics (VA-DILI) is characterised by trifluoroacetyl and CYP2E1 antibodies, but may not be seen for weeks after injury. Interleukin-4 (IL-4) may be involved in the production of these antibodies and may serve as a clinically useful early biomarker of VA-DILI. To prospectively compare serum IL-4 levels between patients who develop VA-DILI and controls following exposure to the volatile anaesthetic. A nested case-control study of patients exposed to VA during surgery was conducted. Thirteen DILI cases were identified from the original cohort, and 26 controls were matched according to age, sex and VA agent. Serum samples were collected before and 48-96 h after VA exposure, and analysed for IL-4 using quantitative enzyme-linked immunosorbent assay techniques. There was a statistically significant difference in serum IL-4 in post-VA samples between DILI cases and controls (control: 0.030 pg/mL, IQR: 0.030 − 0.030 pg/mL vs DILI: 0.044 pg/mL, IQR: 0.030 − 0.061 pg/mL; p = 0.039). A greater proportion of DILI cases had post-VA IL-4 levels above the assay lower limit of detection compared to controls (control: 23% vs DILI: 69%; p = 0.013). IL-4 is a potential biomarker of DILI. Clinical diagnosis and understanding of DILI disease mechanisms may be improved by further investigation of novel biomarkers, and this IL-4 signal in serum is important as proof of concept for prospective study designs.
The Effect of Pathological Types of Intraductal Papillary Mucinous Neoplasms of the Pancreas on Survival
Creators: name: Pezzilli, Raffaele
name: Fabbri, Dario
name: Imbrogno, Andrea
name: Corinaldesi, Roberto
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Pancreatic Neoplasms; Pathology, Clinical; Prognosis; Surgical Procedures, Operative

description: JOP. Journal of the Pancreas, Vol 12, No 3 (2011): May - p. 216-315
Constrained variable clustering and the best basis problem in functional data analysis
Creators: name: Rossi, Fabrice
name: Lechevallier, Yves
Publisher: name: arXiv
Year: 2012
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Functional data analysis involves data described by regular functions rather than by a finite number of real valued variables. While some robust data analysis methods can be applied directly to the very high dimensional vectors obtained from a fine grid sampling of functional data, all methods benefit from a prior simplification of the functions that reduces the redundancy induced by the regularity. In this paper we propose to use a clustering approach that targets variables rather than individual to design a piecewise constant representation of a set of functions. The contiguity constraint induced by the functional nature of the variables allows a polynomial complexity algorithm to give the optimal solution.
title: enquête socio-anthropologique à l’appui de la communication sur le Covid-19 en Afrique de l’Ouest
Creators: name: Seytre, B.
name: Barros, C.
name: Bona, P.
name: Blahima, K.
name: Rodrigues, A.
name: Varela, O.
name: Yoro, B.M.
name: Fall, B.
Publisher: name: Médecine Tropicale et Santé Internationale - Magazine
Year: 2021

description: L’adhésion de la population aux mesures de prévention est cruciale pour le succès de la lutte contre l’épidémie de Covid-19, qu’il s’agisse du respect des gestes barrières ou de la vaccination. Nous avons mené dans cinq pays de la Communauté économique des États d’Afrique de l’Ouest (Burkina Faso, Cap Vert, Côte d’Ivoire, Guinée Bissau, Sierra Leone) une enquête socio-anthropologique sur les représentations du Covid-19 susceptibles d’influencer cette adhésion. Nos résultats montrent que les messages de popularisation des gestes barrières ont extrêmement bien pénétré la population et qu’ils sont parfaitement compris, mais qu’une partie substantielle de la population nie la présence du Covid-19 dans son pays, que la transmission du SARS-CoV2 par des personnes asymptomatiques est majoritairement ignorée, que les facteurs de risque de formes graves de la maladie sont insuffisamment connus et qu’une majorité des enquêtés craint de contracter le Covid-19 en se rendant dans un centre de santé. L’« infodémie » qui circule sur les réseaux sociaux ne semble pas contribuer aux différentes idées fausses que nous avons mises en évidence, idées qui sont le produit des observations et de l’interprétation des personnes interviewées. Nous proposons une réorientation de la communication sur le Covid-19 sur la base des résultats de notre enquête.
description: Médecine Tropicale et Santé Internationale - Magazine, No 1 (2021): MTSI-Magazine
Spanning trees with small degrees and few leaves
Creators: name: Rivera-Campo, Eduardo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We give an Ore-type condition sufficient for a graph G to have a spanning tree with small degrees and with few leaves.
description: Accepted for publication in Applied Mathematics Letters
Hot articles recently published in the field of pancreatology
Creators: name: ., .
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Collected Works; Pancreas; Pancreatic Diseases; Pancreatic Neoplasms

description: JOP. Journal of the Pancreas, Vol 12, No 3 (2011): May - p. 216-315
The role of serology, liver function tests and imaging in screening of primary sclerosing cholangitis: the HelPSCreen score
Creators: name: Barner-Rasmussen, Nina
name: Sjöblom, Nelli
name: Arola, Johanna
name: Boyd, Sonja
name: Kautiainen, Hannu
name: Färkkilä, Martti
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology

description: At present, no sensitive or specific screening test exists for primary sclerosing cholangitis (PSC). PSC screening is mainly based on elevated alkaline phosphatase (ALP) in patients with inflammatory bowel disease (IBD). We aimed to produce a screening score based on laboratory tests to predict the likelihood of PSC. Moreover, we evaluated the additional roles of liver histology and magnetic resonance cholangiopancreatography (MRCP) in the diagnosis of PSC. The data of 385 patients who came for their first endoscopic retrograde cholangiography (ERC) to confirm PSC diagnosis were retrieved from the PSC registry of the Helsinki University Hospital. Overall, 69 patients referred for ERC with suspected PSC, in whom PSC was excluded by ERC or liver biopsy and MRCP, served as controls. We included patients’ demographics and 13 laboratory test results in the analysis. Variables with significant odds ratios were selected for multivariate logistic regression, which was used to create a novel scoring system for PSC. The presence of IBD, serum perinuclear anti-neutrophil cytoplasmic antibodies, and ALP levels demonstrated the highest predictive value for PSC. A score was assigned for each statistically significant predictor. The optimal cut-off point for the score was ≥3, with an AUC of 0.83 (95%CI: 0.78–0.88). The addition of liver histology or MRCP findings to the score did not add a predictive value. In conclusion, we created a novel, simple scoring system to screen the probability of PSC. The HelPSCreen-score may help to assess the disease prevalence and to target further investigations in patients suspected of PSC.
Harnessing deep-sea cold seep microbiomes for reductive dehalogenation: from culturomics and genomics insights
Creators: name: Deng, Zhaochao
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 410501
subject: Environmental biogeochemistry
classificationCode: 410305
subject: Environmental marine biotechnology

description: Deep-sea cold seeps harbor a rich and diverse repertoire of reductive dehalogenase-encoding genes (rdhA), yet their potential for reductive dehalogenation remains largely unexplored. In this study, we investigated the microbial debromination of 2,4,6-tribromophenol (TBP) in cold seep sediment microcosms. By optimizing culture conditions with different nutrient sources and substrate concentrations, we established a highly efficient debrominating microbial consortium capable of completely degrading 50 μM TBP within 72 hours. Metagenomic analysis revealed Bin3, a novel bacterium affiliated with Peptococcaceae, as a key dehalogenator harboring multiple rdhA genes. Microbial community analysis demonstrated that nutrient availability significantly influenced community composition but had no impact on alpha diversity. Through degradation kinetics, co-occurrence network analysis, normalized stochasticity ratio analysis, and metagenomic quantification, we found that supplementing lactate along with 0.05% yeast extract significantly enhanced TBP degradation efficiency and facilitated the targeted enrichment of key dehalogenating microbes (with relative abundance increasing from <1% to 32%). Comparative genomic analysis indicated that Bin3 has undergone species-specific adaptations, including gene families for pili formation, osmolyte transport, and motility, potentially enhancing its competitiveness in deep-sea cold seep environments. This study advances our understanding of deep-sea dehalogenating microbiomes and their adaptation to extreme environments, providing insights into their ecological significance and potential applications in pollutant bioremediation.
Die Erwerbungen der Berliner Museen auf dem Pariser Kunstmarkt während der Besatzungszeit / Les acquisitions des musées berlinois sur le marché de l’art parisien pendant l’Occupation
Creators: name: Lammert, Mattes
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2020

description: -
description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2018/2019
Annealing of single lamella nanoparticles of polyethylene
Creators: name: Rochette, Christophe N.
name: Rosenfeldt, Sabine
name: Henzler, Katja
name: Polzer, Frank
name: Ballauff, Matthias
name: Tong, Qiong
name: Mecking, Stefan
name: Drechsler, Markus
name: Narayanan, Theyencheri
name: Harnau, Ludger
Publisher: name: arXiv
Year: 2011
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study the change of the size and structure of freely suspended single lamella nanoparticles of polyethylene during thermal annealing in aqueous solutions. Using small-angle x-ray scattering and cryogenic transmission electron microscopy, it is shown that a doubling of the crystalline lamella sandwiched between two amorphous polymer layers is obtained by annealing the nanoparticles at 125 C. This thickening of the crystalline lamella can be understood in terms of an unlooping of polymer chains within a single nanoparticle. In addition a variation of the annealing temperature from 90 C to 115 C demonstrates that the inverse of the crystalline lamellar thickness increases linearly with the annealing temperatures leading to a recrystallization line in a Gibbs-Thomson graph. Since the nanoparticles consist of about only eight polymer chains, they can be considered as a ideal candidates for the experimental realization of equilibrium polymer crystals.
Lehre der Wissenschaftlerinnen und Wissenschaftler / Enseignement des chercheurs
Creators: name: Redaktion, Die
Publisher: name: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel
Year: 2020

description: -
description: Deutsches Forum für Kunstgeschichte (DFK Paris): Jahresbericht / Rapport annuel, Jahresbericht / Rapport annuel 2018/2019
Three-Drug Combination Regimen in Pancreatic Cancer Treatment: Are We There Yet?
Creators: name: Kang, Soonmo Peter
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Drug Therapy; Palliative Care; Pancreatic Neoplasms

description: No abstract available.

Image: Herbert Irving Cancer Center. New York, NY, USA
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Skeletally Dugundji spaces
Creators: name: Kucharski, A.
name: Plewik, Sz.
name: Valov, V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Topology (math.GN)
subject: FOS: Mathematics
subject: Primary 54C10, Secondary 54F65

description: We introduce and investigate the class of skeletally Dugundji spaces as a skeletal analogue of Dugundji space. The main result states that the following conditions are equivalent for a given space $X$: (i) $X$ is skeletally Dugundji; (ii) Every compactification of $X$ is co-absolute to a Dugundji space; (iii) Every $C^*$-embedding of the absolute $p(X)$ in another space is strongly $π$-regular; (iv) $X$ has a multiplicative lattice in the sense of Shchepin \cite{s76} consisting of skeletal maps.
Patient-reported burden of skin disorders in coeliac disease
Creators: name: Turjanmaa, Elli
name: Hervonen, Kaisa
name: Huhtala, Heini
name: Arnala, Sanna
name: Reunala, Timo
name: Kaukinen, Katri
name: Salmi, Teea
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: The current knowledge on the associations between coeliac disease and different skin diseases is contradictory and the patient’s perspective on the burden of these is lacking. This study aimed to investigate patient-reported frequency, severity and quality of life effects of skin disorders in coeliac disease patients compared to controls and moreover to study the impacts of gluten-free diet on these skin diseases. A study questionnaire designed for the purposes of this study and a validated Dermatology Life Quality Index (DLQI) questionnaire were posted to 600 adult members of the Finnish Coeliac Society and 1173 matched controls. Responses from 327 coeliac disease patients and 382 non-coeliac controls were compared. Coeliac disease patients were shown to be at no increased risk of atopic dermatitis, acne, rosacea, psoriasis, alopecia areata, vitiligo or chronic urticaria. The severity of these skin diseases did not differ between study groups, but the risk for at least moderate effects on quality of life caused by dermatological diseases was increased among those with coeliac disease. Positive response from gluten-free diet was most commonly experienced by coeliac disease patients with atopic dermatitis. Even though the risk for skin diseases was shown not to be increased among coeliac disease patients, there is still an increased burden related to experienced skin symptoms among these patients, which non-dermatologists treating coeliac disease patients should acknowledge.
Early Detection and Screening of Pancreatic Cancer
Creators: name: Gonda, Tamas A
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Early Detection of Cancer; Metabolomics; Methylation; Pancreatic Neoplasms

description: No abstract available.

Image: Columbia University's New Transparent Medical Center. New York, NY, USA.
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Short-time quantum detection: probing quantum fluctuations
Creators: name: del Rey, Marco
name: Sabin, Carlos
name: Leon, Juan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In this work we study the information provided by a detector click on the state of an initially excited two level system. By computing the time evolution of the corresponding conditioned probability beyond the rotating wave approximation, as needed for short time analysis, we show that a click in the detector is related with the decay of the source only for long times of interaction. For short times, non-rotating wave approximation effects, like self-excitations of the detector, forbid a naïve interpretation of the detector readings. These effects might appear in circuit QED experiments.
description: 5 pages, 5 figures
The Hybrid (Virtual Offsite / Traditional Office) Workplace: Adapting to Strategic Objectives
Creators: name: Zeller, Donna
Publisher: name: Zenodo
Year: 2021
Subjects: Hybrid Virtual Traditional Workplace
Strategic Objectives
Objective Measurements
Analysis and Synthesis

description: Abstract In The Psychology of Management (1921), Dr. Lillian Gilbreth emphasizes the importance of measurement, synthesis, and analysis in management. In the transition to or from a hybrid (virtual / traditional) workplace, the question is how to objectively measure work. Then, the issue is how, or if, the performance data from a virtual office can be compared to a traditional office. Then, how to relate the measurements of the internal (job and business processes regardless of traditional or virtual location) and external (market) environment. Ultimately, the objective is to remain profitable in an evolving market.
EUS-Guided Pancreatic Diagnosis and Beyond
Creators: name: Vignesh, Shivakumar
name: Hoffe, Sarah E
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Endosonography; Fiducial Markers; Pancreatic Neoplasms

description: The therapeutic ability of endoscopic ultrasound has expanded, especially in assisting with radiation planning for image guided radiation techniques such as stereotactic body radiation therapy. Endoscopic ultrasound enables precise placement of fiducial markers into pancreatic cancers to accurately delineate the position of the target lesion as it moves with respiration. The authors summarize the data presented at the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium, including Abstracts #302, #327, #176, #182, and #349.
Image: Dose painting of pancreas protocol CT scan (detail).
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Impact of concomitant cardiovascular medications on overall survival in patients with liver cirrhosis
Creators: name: Li, Moying
name: Itzel, Timo
name: Montagut, Nathally Espinosa
name: Falconer, Thomas
name: Daza, Jimmy
name: Park, Jimyung
name: Cheong, Jae Youn
name: Park, Rae Woong
name: Wiest, Isabella
name: Ebert, Matthias Philip
name: Hripcsak, George
name: Teufel, Andreas
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Liver cirrhosis is the end-stage liver disease associated with poor prognosis and cardiovascular comorbidity could significantly impact mortality of cirrhotic patients. We conducted a large, retrospective study to investigate the survival impact of cardiovascular co-medications in patients with liver cirrhosis. A study-specific R package was processed on the local databases of partner institutions within the Observational Health Data Sciences and Informatics consortium, namely Columbia University, New York City (NYC), USA and Ajou University School of Medicine (AUSOM), South Korea. Patients with cirrhosis diagnosed between 2000 and 2020 were included. Final analysis of the anonymous survival data was performed at Medical Faculty Mannheim, Heidelberg University. We investigated a total of 32,366 patients with liver cirrhosis. Our data showed that administration of antiarrhythmics amiodarone or digoxin presented as a negative prognostic indicator (p = 0.000 in both cohorts). Improved survival was associated with angiotensin-converting enzyme inhibitor ramipril (p = 0.005 in NYC cohort, p = 0.075 in AUSOM cohort) and angiotensin II receptor blocker losartan (p = 0.000 in NYC cohort, p = 0.005 in AUSOM cohort). Non-selective beta blocker carvedilol was associated with a survival advantage in the NYC (p = 0.000) cohort but not in the AUSOM cohort (p = 0.142). Patients who took platelet inhibitor clopidogrel had a prolonged overall survival compared to those without (p = 0.000 in NYC cohort, p = 0.003 in AUSOM cohort). Concomitant cardiovascular medications are associated with distinct survival difference in cirrhotic patients. Multidisciplinary management is needed for a judicious choice of proper cardiovascular co-medications in cirrhotic patients.
Harnessing deep-sea cold seep microbiomes for reductive dehalogenation of 2,4,6-tribromophenol: from culturomics and genomics insights
Creators: name: Deng, Zhaochao
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 410501
subject: Environmental biogeochemistry
classificationCode: 410305
subject: Environmental marine biotechnology

description: Deep-sea cold seeps harbor a rich and diverse repertoire of reductive dehalogenase-encoding genes (rdhA), yet their potential for reductive dehalogenation remains largely unexplored. In this study, we investigated the microbial debromination of 2,4,6-tribromophenol (TBP) in cold seep sediment microcosms. By optimizing culture conditions with different nutrient sources, salinity, and substrate concentrations, we established a highly efficient debrominating microbial consortium capable of completely degrading 50 μM/L TBP within 72 hours. Metagenomic analysis revealed Bin3, a novel bacterium affiliated with Peptococcaceae, as a key dehalogenator harboring multiple rdhA genes. Microbial community analysis demonstrated that nutrient availability significantly influenced community composition but had no impact on alpha diversity. Through degradation kinetics, co-occurrence network analysis, normalized stochasticity ratio analysis, and metagenomic quantification, we found that supplementing lactate as a carbon source along with 0.05% yeast extract significantly enhanced TBP degradation efficiency and facilitated the targeted enrichment of key dehalogenating microbes (with relative abundance increasing from less than 1% to 32%). Comparative genomic analysis indicated that Bin3 has undergone species-specific adaptations, including expanded gene families for pili formation, osmolyte transport, and motility, potentially enhancing its survival in deep-sea cold seep environments. This study advances our understanding of deep-sea dehalogenating microbiomes and their adaptation to extreme environments, providing insights into their ecological significance and potential applications in pollutant bioremediation.
SUSY searches at the Tevatron
Creators: name: Jaffré, Michel
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The Tevatron collider has provided the CDF and D0 collaborations with large datasets as input to a rich program of physics beyond the standard model. The results presented here are from recent searches for SUSY particles using up to 6 fb-1 of data.
description: Presented at the 2011 Hadron Collider Physics Symposium (HCP-2011) Paris, France, November 14-18, 2011, 4 pages, 7 figures; Hadron Collider Physics Symposium (HCP-2011), Paris : France (2011)
Ricci Coefficients in Covariant Dirac Equation, Symmetry Aspects and Newman-Penrose Approach
Creators: name: Red'kov, V. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: G.1
subject: 35

description: The paper investigates how the Ricci rotation coefficients act in the Dirac equation in presence of external gravitational fields described in terms of Riemannian space-time geometry. It is shown that only 8 different combinations of the Ricci coefficients γ_{abc}(x) are involved in the Dirac equation. They are combined in two 4-vectors B_{a}(x) and C_{a}(x) under local Lorentz group which has status of the gauge symmetry group. In all orthogonal coordinates one of these vectors, "pseudovector" C_{a}(x), vanishes identically. The gauge transformation laws of the two vectors are found explicitly. Connection of these B_{a}(x) and A_{a}(x) with the known Newman-Penrose coefficients is established. General study of gauge symmetry aspects in Newman-Penrose formalism is performed. Decomposition of the Ricci object, "tensor" γ_{abc}(x), into two "spinors" γ(x) and \barγ(x) is done. At this Ricci rotation coefficients are divided into two groups:12 complex functions γ(x) and 12 conjugated to them \barγ(x). Components of spinor \barγ(x) coincide with 12 spin coefficients by Newman-Penrose. The formulas for gauge transformations of spin coefficients under local Lorentz group are derived. There are given two solutions to the gauge problem: one in the compact form of transformation laws for spinors γ(x) and \barγ(x), and another as detailed elaboration of the latter in terms of 12 spin coefficients.
description: 17 pages
Identification of Prognostic and Predictive Markers in Pancreatic Adenocarcinoma
Creators: name: Russo, Suzanne M
name: Ove, Roger
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Adenocarcinoma; Biological Markers; MicroRNAs; Molecular Epidemiology; Nomograms; Pancreatic Neoplasms

description: Pancreatic cancer remains a significant cause of morbidity and mortality. While increasing treatment options have improved outcomes for many patients, they have also complicated decision-making for treatment. Unfortunately, most patients with pancreatic cancer die from their disease. Prognostic and predictive markers could play a role to improve treatment by identifying patients who may or may not require a given therapy, and determining those most likely to benefit from a therapy. At the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium held in San Francisco, January 2011, several interesting abstracts were presented that focused on prognostic and predictive markers associated with pancreatic adenocarcinomas. These abstracts discuss progress made in identifying molecular subtypes of pancreatic cancers that may provide insight into selection of patients likely to benefit from certain therapies.

Image: Mitchell Cancer Institute, University of South Alabama. Mobile, AL, USA.
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Table S3. from Developmental origin underlies evolutionary rate variation across the placental skull
Creators: name: Goswami, Anjali
name: Noirault, Eve
name: Coombs, Ellen J.
name: Clavel, Julien
name: Fabre, Anne-Claire
name: Halliday, Thomas J. D.
name: Churchill, Morgan
name: Curtis, Abigail
name: Watanabe, Akinobu
name: Simmons, Nancy B.
name: Beatty, Brian L.
name: Geisler, Jonathan H.
name: Fox, David L.
name: Felice, Ryan N.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Comparison of results of disparity analysis after excluding specimens with missing pterygoids or any missing elements with analysis of the full dataset.
The importance of the local density in shaping the galaxy stellar mass functions
Creators: name: Vulcani, Benedetta
name: Poggianti, Bianca M.
name: Fasano, Giovanni
name: Desai, Vandana
name: Dressler, Alan
name: Oemler, August
name: Calvi, Rosa
name: D'Onofrio, Mauro
name: Moretti, Alessia
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Exploiting the capabilities of four different surveys --- the Padova-Millennium Galaxy and Group Catalogue (PM2GC), the WIde-field Nearby Galaxy-cluster Survey (WINGS), the IMACS Cluster Building Survey (ICBS) and the ESO Distant Cluster Survey (EDisCS) --- we analyze the galaxy stellar mass distribution as a function of local density in mass-limited samples, in the field and in clusters from low (z>0.04) to high (z<0.8) redshift. We find that at all redshifts and in all environments, local density plays a role in shaping the mass distribution. In the field, it regulates the shape of the mass function at any mass above the mass limits. In clusters, it seems to be important only at low masses (log M_ast/M_sun <10.1 in WINGS and log M_ast/M_sun < 10.4 in EDisCS), otherwise it seems not to influence the mass distribution. Putting together our results with those of Calvi et al. and Vulcani et al. for the global environment, we argue that at least at $z\leq 0.8$ local density is more important than global environment in determining the galaxy stellar mass distribution, suggesting that galaxy properties are not much dependent of halo mass, but do depend on local scale processes.
description: MNRAS accepted, in press
First-Line Treatment for Advanced Pancreatic Cancer
Creators: name: Oberstein, Paul E
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Drug Therapy; erlotinib; gemcitabine; Pancreatic Neoplasms

description: Pancreatic adenocarcinoma remains a treatment-refractory cancer. Although pancreatic adenocarcinoma is only the 10th most common cause of new cancer in the United States, it is the fourth most common cause of cancer-related death. Most cases are not suitable for resection and a majority is metastatic at presentation. Gemcitabine, with or without erlotinib, has been the standard chemotherapy in this setting but the benefit is only modest. Because gemcitabine has been considered a standard treatment for advanced pancreatic cancer for the past decade, several randomized trials have tested the combination of gemcitabine plus a second agent, including platinum based agents, topoisomerase inhibitors, taxanes, bevacizumab and cetuximab, as biologically “targeted” agents. At large this approach has not been successful and novel strategies are clearly needed. In this article, the authors summarizes the data from the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium, including: Abstract#175 (review of survival data in a large cohort); Abstract #286 (rapid change in prescriber patterns after the suggestion of benefit of a new regimen, FOLFIRINOX); Abstracts #238, #277, #304, and #315 (phase II trials looking at combinations that utilized EGFR blockade); Abstracts #221, #266, and #284 (phase I/II trials including VEGF blockade, anticoagulation, and traditional Chinese medicines).

Image: Columbia University College of Physicians and Surgeons. New York, NY, USA. (logo)
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Figure S2. from Developmental origin underlies evolutionary rate variation across the placental skull
Creators: name: Goswami, Anjali
name: Noirault, Eve
name: Coombs, Ellen J.
name: Clavel, Julien
name: Fabre, Anne-Claire
name: Halliday, Thomas J. D.
name: Churchill, Morgan
name: Curtis, Abigail
name: Watanabe, Akinobu
name: Simmons, Nancy B.
name: Beatty, Brian L.
name: Geisler, Jonathan H.
name: Fox, David L.
name: Felice, Ryan N.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Bayes Factor comparisons for 10 alternative evolutionary models fitted for each cranial region.
Locally Advanced Pancreatic Adenocarcinoma: Where Are We and Where Are We Going?
Creators: name: Chang, Bryan W
name: Saif, Muhammad W
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: bevacizumab; erlotinib; Fluorouracil; gemcitabine; oxaliplatin; Pancreatic Neoplasms; Radiotherapy

description: Eight abstracts highlighting the continued evolution of the management of locally advanced pancreatic cancer were presented at the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium (Abstracts #195, #239, #259, #281, #287, #305, #307, #324). These studies address key issues including the role of novel targeted therapies, what chemotherapy regimen should be used in conjunction with radiotherapy, and whether locally advanced pancreatic cancer can be managed with chemotherapy alone.

Image: Yale University. New Haven, CT, USA. (logo)
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Table S5. from Developmental origin underlies evolutionary rate variation across the placental skull
Creators: name: Goswami, Anjali
name: Noirault, Eve
name: Coombs, Ellen J.
name: Clavel, Julien
name: Fabre, Anne-Claire
name: Halliday, Thomas J. D.
name: Churchill, Morgan
name: Curtis, Abigail
name: Watanabe, Akinobu
name: Simmons, Nancy B.
name: Beatty, Brian L.
name: Geisler, Jonathan H.
name: Fox, David L.
name: Felice, Ryan N.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Comparison of evolutionary rates across cranial regions. Multivariate net evolutionary rate for each region on diagonal; p-values of pairwise comparisons between regions in lower triangle.
LEASING; BENEFITS, PUBLIC PERCEPTION, REGULATION AND FAIRNESS FOR CONSUMERS
Creators: name: BAYU WICAKSONO
name: BUDI SANTOSO
name: SITI MALIKHATUN B
Publisher: name: Zenodo
Year: 2023
Subjects: Leasing, Lease, Use, Law, Justice, Consumer.

description: Abstract
Leasing; benefits, public perception, regulation and fairness for consumers. The purpose of this study is to analyze: 1) How is leasing beneficial for the user community and how is the public understanding of leasing?; 2) How does the government provide regulations that are able to balance the interests of the parties in  leasing transactions?; 3) How to mean fairness for consumers in leasing  transactions for lessors and lessees? The research method used is empirical juridical with a statutory approach, concept approach, and case studies. The results showed that: a) Leasing is defined as financing activities in the form of providing capital goods, both by lease with option rights (Finance Lease) and lease without option rights (Operating Lease), to be used by Lessee for a certain period of time based on periodic payments (installments. b) The rights and obligations contained in the leasing agreement are contained in Article 1338 paragraph (1) of the Indonesian Civil Code regarding agreements that apply as law to the parties. The agreement has binding and coercive force and provides legal certainty for the parties who make it. So that the parties must obey the agreement the same as obeying the law or in other words the parties must carry out the rights and obligations contained in the agreement properly. c). If in an agreement, the position of the parties is unbalanced, then the weak party is usually not in a state that is completely free to determine what is desired in the agreement.  Therefore, itis our duty to protect the weak to have a strong position.
Periodic travelling waves and compactons in granular chains
Creators: name: James, Guillaume
Publisher: name: arXiv
Year: 2012
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study the propagation of an unusual type of periodic travelling waves in chains of identical beads interacting via Hertz's contact forces. Each bead periodically undergoes a compression phase followed by a free flight, due to special properties of Hertzian interactions (fully nonlinear under compression and vanishing in the absence of contact). We prove the existence of such waves close to binary oscillations, and numerically continue these solutions when their wavelength is increased. In the long wave limit, we observe their convergence towards shock profiles consisting of small compression regions close to solitary waves, alternating with large domains of free flight where bead velocities are small. We give formal arguments to justify this asymptotic behaviour, using a matching technique and previous results concerning solitary wave solutions. The numerical finding of such waves implies the existence of compactons, i.e. compactly supported compression waves propagating at a constant velocity, depending on the amplitude and width of the wave. The beads are stationary and separated by equal gaps outside the wave, and each bead reached by the wave is shifted by a finite distance during a finite time interval. Below a critical wavenumber, we observe fast instabilities of the periodic travelling waves leading to a disordered regime.
description: To appear in Journal of Nonlinear Science
Adjuvant Therapy of Pancreatic Cancer: Beyond Gemcitabine
Creators: name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: Chemotherapy, Adjuvant; Fluorouracil; gemcitabine; Pancreatic Neoplasms; Radiotherapy

description: There is no consensus on what constitutes “standard” adjuvant therapy for pancreatic cancer. This controversy derives from several studies, each fraught with its own limitations. Standards of care also vary somewhat on the geography as chemo-radiotherapy followed by chemotherapy or vice versa is considered the optimal therapy in North America (GITSG, RTOG) while chemotherapy alone is the current standard in Europe (ESPAC-1, CONKO, ESPAC-3). The high rate of locoregional failure following surgical resection for adenocarcinoma of the pancreas has made it clear that some form of adjuvant therapy should be considered in these patients. A phase II study was presented at the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium to assess the effect of the addition of algenpantucel-L immunotherapy to standard adjuvant therapy on survival in patients with resected pancreas cancer (Abstract #236). The author reviews the abstract in the context of our previous knowledge.

Image: Hyperacute rejection and immunotherapeutic applications.
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Treatment for Refractory Pancreatic Cancer
Creators: name: Makrilia, Nektaria
name: Syrigos, Kostas N
name: Saif, Muhammad W
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: gemcitabine; irinotecan; Pancreatic Neoplasms; Treatment Failure

description: While gemcitabine-based regimens are currently accepted as the standard first-line treatment of patients with locally advanced or metastatic pancreatic adenocarcinoma, there is no consensus regarding treatment in the second-line setting. This review is an update from the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium regarding recent developments in the treatment of refractory pancreatic cancer, as these were presented in Abstracts #237 and #272 of the meeting.

Image: Sophia Engastromenou Schliemann (the founder of the "Sotiria"/"Salvation" Hospital) wearing the "Jewels of Helen" (photograph taken ca. 1874).
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Test–retest reliability of selected HBSC items in Vietnam: well-being, physical and sedentary activities, and eating behaviours
Creators: name: Kohoutek, Jaroslav
name: Maráček, Marek
name: NG, KWOK
name: Hamrik, Zdenek
Publisher: name: University of Limerick
Year: 2023

description: Background: Valid and reliable research tools to assess children’s and adolescent’s health-related behaviour are highly needed across the globe. Rapid economic development, globalization, and associated lifestyle challenges observed in most countries support the need for high-quality evidence in adolescents to target health-promoting policies and interventions. This study aims to examine the test–retest reliability of selected well-being, physical and screen-time related siting activities, and eating behaviour items of the Health Behaviour in School-Aged Children (HBSC) questionnaire in a sample of Vietnamese adolescents. Methods: Data were collected in autumn 2018 in Vietnam (3-week interval). The sample consisted of 410 adolescents (41.0% of boys; mean age=12.61; SD=1.24).Test–retest reliability was evaluated using the single measure Intra-class Correlation Coefcients (ICC) and Cohen’s kappa statistic stratifed by sex, grade and place of residence (urban or rural). Results: The reliability analyses of the well-being items were poor to good ICC values (0.43–0.79) and moderate to large Cohen’s kappa values (0.33–0.77). The physical activity and eating behaviour items were moderate (ICC=0.54–0.65; Cohen’s kappa=0.38–0.57). The screen-time related siting activities items were moderate to large (ICC=0.51–0.72; Cohen’s kappa=0.42–0.53). There was more item stability among females than males. The social media item was not as stable for 6th graders (ICC=0.45) compared with older adolescents (ICC 0.68–0.77). Conclusions: The fndings show that with regards to age, sex and place of residence, self-reported health, life satisfaction, physical and screen-time related siting activities, as well as eating behaviour items of the HBSC questionnaire have a sufcient test–retest reliability to be used in national self-report surveys for Vietnamese adolescents while health complaints items showed borderline reliability.
Single attosecond pulse from terahertz-assisted high-order harmonic generation
Creators: name: Balogh, Emeric
name: Kovacs, Katalin
name: Dombi, Peter
name: Fulop, Jozsef A.
name: Farkas, Gyozo
name: Hebling, Janos
name: Tosa, Valer
name: Varju, Katalin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: High-order harmonic generation by few-cycle 800 nm laser pulses in neon gas in the presence of a strong terahertz (THz) field is investigated numerically with propagation effects taken into account. Our calculations show that the combination of THz fields with up to 12 fs laser pulses can be an effective gating technique to generate single attosecond pulses. We show that in the presence of the strong THz field only a single attosecond burst can be phase matched, whereas radiation emitted during other half-cycles disappears during propagation. The cutoff is extended and a wide supercontinuum appears in the near-field spectra, extending the available spectral width for isolated attosecond pulse generation from 23 to 93 eV. We demonstrate that phase matching effects are responsible for the generation of isolated attosecond pulses, even in conditions when single atom response yields an attosecond pulse train.
Novel Agents in the Management of Pancreatic Adenocarcinoma: Phase I Studies
Creators: name: Dimou, Anastasios T
name: Syrigos, Konstantinos N
name: Saif, Muhammad Wasif
Publisher: name: JOP. Journal of the Pancreas
Year: 2011
Subjects: adverse effects; Clinical Trials, Phase I as Topic; Mitogen-Activated Protein Kinase Kinases; Pancreatic Neoplasms

description: Pancreatic adenocarcinoma has repetitively proved refractory to chemotherapy and biologic compounds with only a few drugs offering limited benefit. A number of novel regimens has been tested in phase I trials and reported recently in the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium. Specifically, a novel mitogen-activated protein kinase kinase (MEK) inhibitor, a connective tissue growth factor inhibitor, a coagulase factor VIIa inhibitor, as well as adenovirus delivery of herpes simplex virus thymidine synthase gene followed by anti-herpetic treatment have all proven to be safe in pancreatic cancer patients. Phase II trials will provide further evidence whether they can become clinically relevant in the future.

Image: Yale University School of Medicine. New Haven, CT, USA (logo).
description: JOP. Journal of the Pancreas, Vol 12, No 2 (2011): March - p. 78-215
Evaluation results of the paper "SIMOD: Automated Discovery of Business Process Simulation Models"
Creators: name: Chapela-Campa, David
name: López-Pintado, Orlenys
name: Suvorau, Ihar
name: Dumas, Marlon
Publisher: name: Zenodo
Year: 2025
Subjects: process mining
business process simulation
bps model
digital twin
business process management
simod

description: Business Process Simulation Models discovered by SIMOD in the evaluation of the paper "SIMOD: Automated Discovery of Business Process Simulation Models", by David Chapela-Campa, Orlenys López-Pintado, Ihar Suvorau, and Marlon Dumas.

The datasets used for this evaluation can be found at https://doi.org/10.5281/zenodo.6719730 (Warning! Edit the activity names of the BPIC2012 and BPIC2017 event logs by removing the initial white space before running SIMOD).

bps-models: output folder of SIMOD for each dataset and configuration executed. Each folder contains the result BPS model, configuration files, and the simulated logs used for the evaluation of the BPS model ('clarificaton-note.txt' describes the content of each of the files).

config: configuration files used to run each version of SIMOD.
Control over stress induces plasticity of individual prefrontal cortical neurons: A conductance-based neural simulation
Creators: name: Varela, Juan A.
name: Wang, Jungang
name: Varnell, Andrew L.
name: Cooper, Donald C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Behavioral control over stressful stimuli induces resilience to future conditions when control is lacking. The medial prefrontal cortex(mPFC) is a critically important brain region required for plasticity of stress resilience. We found that control over stress induces plasticity of the intrinsic voltage-gated conductances of pyramidal neurons in the PFC. To gain insight into the underlying biophysical mechanisms of this plasticity we used the conductance- based neural simulation software tool, NEURON, to model the increase in membrane excitability associated with resilience to stress. A ball and stick multicompartment conductance-based model was used to realistically fit passive and active data traces from prototypical pyramidal neurons in neurons in rats with control over tail shock stress and those lacking control. The results indicate that the plasticity of membrane excitability associated with control over stress can be attributed to an increase in Na+ and Ca2+ T-type conductances and an increase in the leak conductance. Using simulated dendritic synaptic inputs we observed an increase in excitatory postsynaptic summation and amplification resulting in elevated action potential output. This realistic simulation suggests that control over stress enhances the output of the PFC and offers specific testable hypotheses to guide future electrophysiological mechanistic studies in animal models of resilience and vulnerability to stress.
description: 2 pages 2 figures Nature Precedings (2011)