cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Perceptions of and interest in HIV pre-exposure prophylaxis use among adolescent girls and young women in Lilongwe, Malawi
Creators: name: Phanga, T.
name: Hill, L.M.
name: Bekker, L.-G.
name: Vansia, D.
name: Hosseinipour, M.C.
name: Rosenberg, N.E.
name: Maseko, B.
name: Bhushan, N.
name: Kamtsendero, L.
name: Pettifor, A.E.
Publisher: name: Public Library of Science
Year: 2020

description: Background Oral Pre-Exposure Prophylaxis (PrEP) is an effective HIV prevention strategy for adherent users. Adolescent girls and young women (AGYW) in sub-Saharan Africa may particularly benefit from PrEP because of the disproportionate burden of HIV in this group. Understanding potential users’ perceptions of and interest in using PrEP is critical to promote the utilization of PrEP by individuals at risk of HIV. Methods This qualitative investigation of AGYW’s knowledge of and interest in PrEP use was conducted in the context of Girl Power, a quasi-experimental cohort study comparing four models of service delivery at four health centers in Lilongwe, Malawi. We conducted individual in-depth interviews (IDIs) with 40 HIV-negative AGYW ages 15–24 years old six months after enrolment in the parent study. An explanation of PrEP was provided to participants. Interview topics included participants’ prior knowledge of, interest in, concerns about, and delivery preferences for PrEP. Analysis consisted of structural coding of interview transcripts corresponding to interview topics, summary of responses within these topics, and identification and description of emerging themes within each topic. Results None of the AGYW had knowledge of PrEP prior to the IDIs, but once explained, a majority expressed an interest in using it due to inconsistencies in condom use, condom use errors, their own or their partners’ concurrent sexual partnerships, and rape. Most AGYW hoped that PrEP would be available in youth-friendly sections of health centers for easy access and youth-friendly counselling. They suggested that discrete packaging of PrEP would be needed to ensure user privacy. Concerns about relationship destabilization and accusations of promiscuity were raised as potential barriers to use. Conclusion General interest in PrEP among AGYW was high. Discrete packaging and access to youth-friendly PrEP delivery modalities may facilitate the utilization of PrEP as a prevention strategy among sexually active AGYW. Attention to potential negative reactions from partners and community members to PrEP use will be needed when introducing PrEP to this population.
A Novel Solution to the Gravitino Problem
Creators: name: Qiu, Yu-Cheng
name: Tye, S. -H. Henry
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In a general phenomenological model with local supersymmetry, the amount of massive gravitinos produced in early universe tends to violate the known dark matter density bound by many orders of magnitude. In the brane world scenario in Type IIB string theory, we propose a novel way to evade this problem. There, the standard model of strong and electroweak interactions live inside the anti-${\rm D3}$-branes ($\overline{\rm D3}$-branes) that span the 3 large spatial dimensions. Here, the "potential" Goldstino to be absorbed by the gravitino (to become massive) is the fermion component of the open string nilpotent superfield $X$ (i.e., $X^2=0$) which is present only inside the $\overline{\rm D3}$-branes. This non-linear supergravity scenario offers 2 ways to solve the gravitino problem, with very different particle physics phenomenologies.
description: This revised version explains some points that are confusing in the earlier version. The current version is the same as the published version. 23 pages, 1 figure, 2 tables
Gaining traction: Promising shifts in gender norms and intimate partner violence in the context of a community-based HIV prevention trial in South Africa
Creators: name: Twine, R.
name: Kang Dufour, M.-S.
name: Mathebula, R.
name: Gómez-Olivé, F.X.
name: Gottert, A.
name: Spielman, K.
name: Pulerwitz, J.
name: Pettifor, A.
name: Peacock, D.
name: Rebombo, D.
name: West, R.
name: Lippman, S.A.
name: Haberland, N.
name: Kahn, K.
name: Julien, A.
Publisher: name: NLM (Medline)
Year: 2020

description: BACKGROUND: HIV and violence prevention programs increasingly seek to transform gender norms among participants, yet how to do so at the community level, and subsequent pathways to behavior change, remain poorly understood. We assessed shifts in endorsement of equitable gender norms, and intimate partner violence (IPV), during the three-year community-based trial of Tsima, an HIV 'treatment as prevention' intervention in rural South Africa. METHODS: Cross-sectional household surveys were conducted with men and women ages 18-49 years, in 8 intervention and 7 control communities, at 2014-baseline (n = 1,149) and 2018-endline (n = 1,189). Endorsement of equitable gender norms was measured by the GEM Scale. Intent-to-treat analyses assessed intervention effects and change over time. Qualitative research with 59 community members and 38 staff examined the change process. RESULTS: Nearly two-thirds of men and half of women in intervention communities had heard of the intervention/seen the logo; half of these had attended a two-day workshop. Regression analyses showed a 15% improvement in GEM Scale score over time, irrespective of the intervention, among men (p<0.001) and women (p<0.001). Younger women (ages 18-29) had a decreased odds of reporting IPV in intervention vs. control communities (aOR 0.53; p<0.05). Qualitative data suggest that gender norms shifts may be linked to increased media access (via satellite TV/smartphones) and consequent exposure to serial dramas modeling equitable relationships and negatively portraying violence. Tsima's couple communication/conflict resolution skills-building activities, eagerly received by intervention participants, appear to have further supported IPV reductions. CONCLUSIONS: There was a population-level shift towards greater endorsement of equitable gender norms between 2014-2018, potentially linked with rapid escalation in media access. There was also an intervention effect on reported IPV among young women, likely owing to improved couple communication. Societal-level gender norm shifts may create enabling environments for interventions to find new traction for violence and HIV-related behavior change.
(386) Elizabeth Watt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Adolescents and young people at the centre: global perspectives and approaches to transform HIV testing, treatment and care
Creators: name: Toska, E.
name: Pettifor, A.E.
name: Archary, M.
Publisher: name: John Wiley and Sons Inc.
Year: 2020

description: In this special issue of the Journal of the International AIDS Society, we focus on research and perspectives that put adolescents and young people at the centre of their HIV prevention and care. Globally over two million adolescents are living with HIV, while many more are at risk of HIV infection. In contrast to reductions globally and in highest burden regions in the general population, estimates suggest that HIV incidence and mortality persist among adolescents and young people. Young people continue be less likely to test for HIV, to link to care in a timely way and to stay engaged in care if they test HIV positive compared to adults. Although, these disparities in access to HIV prevention and care have been documented over the last decade, the evidence base of models, programmes and tools to address the challenges young people face is limited. This special issue documents a series of promising and effective approaches that support adolescents and young people, not only to access and use HIV prevention and care, but also to live whole and fulfilling lives. The articles in this issue bring together evidence and lessons learned from a number of global settings, unified by one clear message: young people need and want to be at the centre of their HIV prevention and care programmes.
Bounds and convex heuristics for bi-objective optimal experiment design in water networks
Creators: name: Pecci, Filippo
name: Stoianov, Ivan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: Optimal Experiment Design for parameter estimation in water networks has been traditionally formulated to maximize either hydraulic model accuracy or spatial coverage. Because a unique sensor configuration that optimizes both objectives may not exist, these approaches inevitably result in sub-optimal configurations with respect to one of the objectives. This paper presents a new bi-objective optimization problem formulation to investigate the trade-offs between these conflicting objectives. We develop a convex heuristic to approximate the Pareto front, and compute guaranteed bounds to discard portions of the criterion space that do not contain non-dominated solutions. Our method relies on a Chebyshev scalarization scheme and convex optimization. We implement the proposed methods for optimal experiment design in an operational water network from the UK. For this case study, the convex heuristic computes near-optimal solutions for the individual objective minimization problems, and tight bounds on the true Pareto front of the considered bi-objective optimization problem.
HIV risk, risk perception, and PrEP interest among adolescent girls and young women in Lilongwe, Malawi: operationalizing the PrEP cascade
Creators: name: Pettifor, A.
name: Chagomerana, M.
name: Hosseinipour, M.C.
name: Hill, L.M.
name: Maseko, B.
name: Bekker, L.-G.
name: Rosenberg, N.E.
Publisher: name: John Wiley and Sons Inc.
Year: 2020

description: Introduction: As a user-controlled HIV prevention method, oral pre-exposure prophylaxis (PrEP) holds particular promise for adolescent girls and young women (AGYW). HIV prevention cascades, critical frameworks for the design and evaluation of PrEP programmes, outline the priorities of identifying individuals at greatest HIV risk and motivating them to initiate PrEP through perceived HIV risk. To inform future iterations of these cascades and PrEP delivery for AGYW, the objective of this study was to understand the level of interest in PrEP among AGYW at highest HIV risk, and the potential role of perceived risk in motivating PrEP interest. Methods: Using data from a cohort study of HIV-negative AGYW in Lilongwe, Malawi (February 2016 to August 2017), we assessed the relationship between epidemiologic HIV risk (risk index developed in a previous analysis) and PrEP interest, and the extent to which perceived risk explains the relationship between HIV risk and PrEP interest. We further aimed to operationalize the pre-initiation steps of the HIV prevention cascade in the study population. Results: In total, 825 AGYW were included in analyses, of which 43% met the criterion for high epidemiologic HIV risk. While epidemiologic risk scores were positively associated with PrEP interest, high numbers of AGYW both above and below the high-risk cutoff were very interested in PrEP (68% vs. 63%). Perceived risk partially explained the relationship between HIV risk and PrEP interest; greater epidemiologic HIV risk was associated with high perceived risk, which was in turn associated with PrEP interest. Many more high-risk AGYW were interested in PrEP (68%) than expressed a high level of perceived HIV risk (26%). Conclusions: These results highlight key relationships between epidemiologic HIV risk, risk perception and interest in PrEP. While risk perception did partially explain the relationship between epidemiologic risk and PrEP interest, there may be other important motivational mechanisms that are not captured in many HIV prevention cascades. The high number of participants with risk scores below the high-risk cutoff who both expressed high perceived risk and interest in PrEP suggests that demand for PrEP among AGYW may not be well aligned with epidemiologic risk.
The relationship between intimate partner violence and probable depression among adolescent girls and young women in Lilongwe, Malawi
Creators: name: Brar, S.K.
name: Rosenberg, N.E.
name: Phanga, T.
name: Bekker, L.-G.
name: Abas, M.
name: Vansia, D.
name: Beattie, T.S.H.
name: Maseko, B.
name: Pettifor, A.E.
Publisher: name: Routledge
Year: 2020

description: This analysis estimates prevalence of intimate partner violence (IPV) and its association with probable depression among adolescent girls and young women (AGYW) in Lilongwe, Malawi, and whether partner’s controlling behaviour modifies this relationship. Baseline data was utilised from the Girl Power-Malawi study of 1000 15–24-year-old AGYW in Lilongwe. Emotional, physical, and sexual IPV experiences with a current or recent partner were measured using the modified Conflict Tactics Scale. Probable depression was measured by scoring ≥10 on the Centre for Epidemiologic Studies-Short Depression Scale (CES-D-10). Generalised linear models with log-link and binomial distribution estimated prevalence ratios (PR) and 95% confidence intervals (CI) for the association between IPV types and probable depression. Partner’s controlling behaviour was examined as an effect modifier. Participants’ mean age was 19.2 years, with 70% never-married. IPV prevalence varied for emotional (59%), physical (36%), sexual (46%), and all forms (20%). Prevalence of probable depression was 47%. AGYW who experienced each IPV type had a higher prevalence of probable depression: physical (PR:1.54, CI:1.28–1.86), sexual (1.46, CI:1.21–1.75), emotional (1.37, CI:1.14–1.64), all forms (1.72, CI:1.41–2.09). IPV and probable depression were prevalent and strongly associated, especially among AGYW reporting controlling behaviour. Interventions addressing IPV and controlling behaviour may positively impact depression among AGYW.
Stability of moving solitons in trans-polyacetylene in an electric field
Creators: name: Arancibia, Leandro M.
name: Sánchez, Cristián G.
name: Lobos, Alejandro M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this work we study the dynamics and stability of charged solitons in trans-polyacetylene (tPA), and revisit the issue of the stability of these non-linear excitations under the effect of an external electric field applied parallel to the polymer. Using the formalism of the Su-Schrieffer-Heeger (SSH) model, we solve the coupled dynamical equations for electrons and classical nuclei at the mean-field level and in the regime of low external electric field $E$, where the dynamics of the moving soliton is adiabatic. Analyzing observable quantities in real space and frequency space, we identify the microscopic mechanisms triggering the dynamical instabilities of the soliton. In addition, we put forward the definition of a proper quantitative measure of its stability, an issue which to the best of our knowledge has remained an open question. Besides its intrinsic interest from the fundamental point of view, our work might be relevant for the design of novel organic electronic devices based on soliton-mediated transport.
description: 14 pages, 9 figures, 1 appendix
(383) Margaret Barclay Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Comparing models for the ground state energy of a trapped one-dimensional Fermi gas with a single impurity
Creators: name: Loft, N. J. S.
name: Kristensen, L. B.
name: Thomsen, A. E.
name: Zinner, N. T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss the local density approximation approach to calculating the ground state energy of a one-dimensional Fermi gas containing a single impurity, and compare the results with exact numerical values that we have for up to 11 particles for general interaction strengths and up to 30 particles in the strongly interacting case. We also calculate the contact coefficient in the strongly interacting regime. The different theoretical predictions are compared to recent experimental results with few-atom systems. Firstly, we find that the local density approximation suffers from great ambiguity in the few-atom regime, yet it works surprisingly well for some models. Secondly, we find that the strong interaction theories quickly break down when the number of particles increase or the interaction strength decreases.
description: 10 pages, 4 figures, 2 tables, final version
Direct observation of the energy release site in a solar flare by SDO/AIA, Hinode/EIS and RHESSI
Creators: name: Simões, Paulo J. A.
name: Graham, David R.
name: Fletcher, Lyndsay
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present direct evidence for the detection of the main energy release site in a non-eruptive solar flare, SOL2013-11-09T06:38UT. This GOES C2.7 event was characterised by two flaring ribbons and a compact, bright coronal source located between them, which is the focus of our study. We use imaging from SDO/AIA, and imaging spectroscopy from RHESSI to characterise the thermal and non-thermal emission from the coronal source, and EUV spectroscopy from the Hinode/EIS, which scanned the coronal source during the impulsive peak, to analyse Doppler shifts in Fe XII and Fe XXIV emission lines, and determine the source density. The coronal source exhibited an impulsive emission lightcurve in all AIA filters during the impulsive phase. RHESSI hard X-ray images indicate both thermal and non-thermal emission at the coronal source, and its plasma temperature derived from RHESSI imaging spectroscopy shows an impulsive rise, reaching a maximum at 12-13 MK about 10 seconds prior to the hard X-ray peak. High redshifts associated with this bright source indicate downflows of 40-250 km/s at a broad range of temperatures, interpreted as loop shrinkage and/or outflows along the magnetic field. Outflows from the coronal source towards each ribbon are also observed by AIA images at 171, 193, 211, 304 and 1600 A. The electron density of the source obtained from a Fe XIV line pair is $10^{11.50}$ which is collisionally thick to electrons with energy up to 45-65 keV, responsible for the source's non-thermal X-ray emission. We conclude that the bright coronal source is the location of the main release of magnetic energy in this flare, with a geometry consistent with component reconnection between crossing, current-carrying loops. We argue that the energy that can be released via reconnection, based on observational estimates, can plausibly account for the non-thermal energetics of the flare.
description: 10 pages, 7 figures
(381) Alexander Barclay Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Lensing in the McVittie metric
Creators: name: Piattella, Oliver F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the effect of the cosmological expansion on the bending of light due to an isolated point-like mass. We adopt McVittie metric as the model for the geometry of the lens. Assuming a constant Hubble factor we find an analytic expression involving the bending angle, which turns out to be unaffected by the cosmological expansion at the leading order.
description: 4 pages, 3 figures. Mistakes corrected. Conclusions completely changed
A new sdO+dM binary with extreme eclipses and reflection effect
Creators: name: Derekas, A.
name: Nemeth, P.
name: Southworth, J.
name: Borkovits, T.
name: Sarneczky, K.
name: Pal, A.
name: Csak, B.
name: Garcia-Alvarez, D.
name: Maxted, P. F. L.
name: Kiss, L. L.
name: Vida, K.
name: Szabo, Gy. M.
name: Kriskovics, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the discovery of a new totally-eclipsing binary (RA=06:40:29.11; Dec=+38:56:52.2; J=2000.0; Rmax=17.2 mag) with an sdO primary and a strongly irradiated red dwarf companion. It has an orbital period of Porb=0.187284394(11) d and an optical eclipse depth in excess of 5 magnitudes. We obtained two low-resolution classification spectra with GTC/OSIRIS and ten medium-resolution spectra with WHT/ISIS to constrain the properties of the binary members. The spectra are dominated by H Balmer and He II absorption lines from the sdO star, and phase-dependent emission lines from the irradiated companion. A combined spectroscopic and light curve analysis implies a hot subdwarf temperature of Teff(spec) = 55 000 +/- 3000K, surface gravity of log g(phot) = 6.2 +/- 0.04 (cgs) and a He abundance of log(nHe/nH) = -2.24 +/- 0.40. The hot sdO star irradiates the red-dwarf companion, heating its substellar point to about 22 500K. Surface parameters for the companion are difficult to constrain from the currently available data: the most remarkable features are the strong H Balmer and C II-III lines in emission. Radial velocity estimates are consistent with the sdO+dM classification. The photometric data do not show any indication of sdO pulsations with amplitudes greater than 7mmag, and Halpha-filter images do not provide evidence of the presence of a planetary nebula associated with the sdO star.
description: 13 pages, 5 figures; accepted for publication in ApJ
Aharonov-Bohm oscillations in bilayer graphene edge state Fabry-Pérot interferometers
Creators: name: Fu, Hailong
name: Huang, Ke
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Kayyalha, Morteza
name: Zhu, Jun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The charge and exchange statistics of an elementary excitation manifest in quantum coherent oscillations that can be explored in interferometry measurements. Quantum Hall interferometers are primary tools to uncover unconventional quantum statistics associated with fractional and non-Abelian anyons of a two-dimensional system, the latter being the foundation of topological quantum computing. Graphene interferometers offer new avenues to explore the physics of exotic excitations due to their relatively small charging energies and sharp confinement potentials. Bilayer graphene possesses a true band gap to facilitate the formation of quantum confinement and exhibits the most robust even-denominator fractional quantum Hall states that may host non-Abelian anyons. Here we present the design and fabrication of a split-gated bilayer graphene Fabry-Pérot interferometer and experimental evidence of Aharonov-Bohm interference at multiple integer quantum Hall states. The versatility of the device allows us to study a wide range of scenarios, determine the velocities of edge states, and assess dephasing mechanisms of the interferometer. These results pave the way to the quest of non-Abelian statistics in this promising device platform.
description: 14 pages, 3 figures, and 2 tables
Decision-making and cash spending patterns of adolescent girls and young women participating in a cash-transfer intervention in Tanzania: Implications for sexual health
Creators: name: Maman, S.
name: Wamoyi, J.
name: Majani, E.
name: Balvanz, P.
name: Pettifor, A.
name: Mugunga, S.
name: Gichane, M.W.
Publisher: name: Routledge
Year: 2020

description: Although cash transfers (CT) have been recommended as a strategy to address structural drivers of HIV, the evidence of the effects of CT on sexual risk and HIV outcomes is mixed. This could partly be due to CT implementation dynamics and beneficiary interpersonal factors. We conducted an assessment of CT component of the DREAMS programme in Tanzania. We explored how AGYW spent their CT over time, to whom they disclosed cash receipt, and where they sought advice on CT use. The study employed qualitative research methods including: 20 longitudinal in-depth interviews (IDIs) and 60 cross-sectional IDIs with AGYW in the CT programme. Data were analysed thematically. AGYW use of CT fell into five categories: business development, survival, self-care, helping family, and savings. The primary uses of CT funds were investment in businesses and livestock for savings. AGYW use of cash changed over instalments. AGYW consulted a variety of sources when deciding on how to use the cash, primarily mothers, programme personnel, and long-term partners/husbands. CT programmes that give cash directly to AGYW and have a strong entrepreneurial mentorship component could have implications for HIV prevention, SRH, and overall social and economic development.
(382) Dugald Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Depression and Incident HIV in Adolescent Girls and Young Women in HIV Prevention Trials Network 068: Targets for Prevention and Mediating Factors
Creators: name: Neilands, T.B.
name: Stein, A.
name: Tollman, S.
name: Selin, A.
name: Ahern, J.
name: Craske, M.G.
name: Laeyendecker, O.
name: Wagner, R.G.
name: Hamilton, E.L.
name: MacPhail, C.
name: Lippman, S.A.
name: Kahn, K.
name: Hughes, J.P.
name: Twine, R.
name: Gomez-Olive, F.X.
name: Goin, D.E.
name: Pettifor, A.
name: Agyei, Y.
name: Pearson, R.M.
Publisher: name: NLM (Medline)
Year: 2020

description: The human immunodeficiency virus (HIV) epidemic among adolescent girls and young women (AGYW) in sub-Saharan Africa is a critical public health problem. We assessed whether depressive symptoms in AGYW were longitudinally associated with incident HIV, and identified potential social and behavioral mediators. Data came from a randomized trial of a cash transfer conditional on school attendance among AGYW (ages 13-21 years) in rural Mpumalanga Province, South Africa, during 2011-2017. We estimated the relationship between depressive symptoms and cumulative HIV incidence using a linear probability model, and we assessed mediation using inverse odds ratio weighting. Inference was calculated using the nonparametric bootstrap. AGYW with depressive symptoms had higher cumulative incidence of HIV compared with those without (risk difference = 3.5, 95% confidence interval (CI): 0.1, 7.0). The strongest individual mediators of this association were parental monitoring and involvement (indirect effect = 1.6, 95% CI: 0.0, 3.3) and reporting a partner would hit her if she asked him to wear a condom (indirect effect = 1.5, 95% CI: -0.3, 3.3). All mediators jointly explained two-thirds (indirect effect = 2.4, 95% CI: 0.2, 4.5) of the association between depressive symptoms and HIV incidence. Interventions addressing mental health might reduce risk of acquiring HIV among AGYW.
Limitations of the UNAIDS 90-90-90 metrics: a simulation-based comparison of cross-sectional and longitudinal metrics for the HIV care continuum
Creators: name: Harling, G.
name: Pettifor, A.
name: Haber, N.A.
name: Anglemyer, A.
name: Salomon, J.A.
name: Lippman, S.A.
name: Lesko, C.R.
name: Edwards, J.K.
name: Chang, A.Y.
name: Fox, M.P.
name: Bor, J.
name: Powers, K.A.
Publisher: name: NLM (Medline)
Year: 2020

description: OBJECTIVES: The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 and other cross-sectional metrics can lead to potentially counterintuitive conclusions when used to evaluate health systems' performance. This study demonstrates how time and population dynamics impact UNAIDS 90-90-90 metrics in comparison with a longitudinal analogue. DESIGN: A simplified simulation representing a hypothetical population was used to estimate and compare inference from UNAIDS 90-90-90 metrics and longitudinal metrics based on Kaplan-Meier-estimated 2-year probability of transition between stages. METHODS: We simulated a large cohort over 15 years. Everyone started out at risk for HIV, and then transitioned through the HIV care continuum based on fixed daily probabilities of acquiring HIV, learning status, entering care, initiating antiretroviral therapy (ART), and becoming virally suppressed, or dying. We varied the probability of ART initiation over three five-year periods (low, high, and low). We repeated the simulation with an increased probability of death. RESULTS: The cross-sectional probability of being on ART among persons who were diagnosed responded relatively slowly to changes in the rate of ART initiation. Increases in ART initiation rates caused apparent declines in the cross-sectional probability of being virally suppressed among persons who had initiated ART, despite no changes in the rate of viral suppression. In some cases, higher mortality resulted in the cross-sectional metrics implying improved healthcare system performance. The longitudinal continuum was robust to these issues. CONCLUSION: The UNAIDS 90-90-90 care continuum may lead to incorrect inference when used to evaluate health systems performance. We recommend that evaluation of HIV care delivery include longitudinal care continuum metrics wherever possible.
Depletion of Nonlinearity in Magnetohydrodynamic Turbulence: Insights from Analysis and Simulations
Creators: name: Gibbon, J. D.
name: Gupta, A.
name: Krstulovic, G.
name: Pandit, R.
name: Politano, H.
name: Ponty, Y.
name: Pouquet, A.
name: Sahoo, G.
name: Stawarz, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We build on recent developments in the study of fluid turbulence [Gibbon \textit{et al.} Nonlinearity 27, 2605 (2014)] to define suitably scaled, order-$m$ moments, $D_m^{\pm}$, of $ω^\pm= ω\pm j$, where $ω$ and $j$ are, respectively, the vorticity and current density in three-dimensional magnetohydrodynamics (MHD). We show by mathematical analysis, for unit magnetic Prandtl number $P_M$, how these moments can be used to identify three possible regimes for solutions of the MHD equations; these regimes are specified by inequalities for $D_m^{\pm}$ and $D_1^{\pm}$. We then compare our mathematical results with those from our direct numerical simulations (DNSs) and thus demonstrate that 3D MHD turbulence is like its fluid-turbulence counterpart insofar as all solutions, which we have investigated, remain in \textit{only one of these regimes}; this regime has depleted nonlinearity. We examine the implications of our results for the exponents $q^{\pm}$ that characterize the power-law dependences of the energy spectra $\mathcal{E}^{\pm}(k)$ on the wave number $k$, in the inertial range of scales. We also comment on (a) the generalization of our results to the case $P_M \neq 1$ and (b) the relation between $D_m^{\pm}$ and the order-$m$ moments of gradients of hydrodynamic fields, which are used in characterizing intermittency in turbulent flows.
description: 14 pages, 3 figures
Towards coarse-grained elasticity of single-layer Covalent Organic Frameworks
Creators: name: Croy, Alexander
name: Raptakis, Antonios
name: Bodesheim, David
name: Dianat, Arezoo
name: Cuniberti, Gianaurelio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Two-dimensional covalent organic frameworks (2D COFs) are an interesting class of 2D materials since their reticular synthesis allows the tailored design of structures and functionalities. For many of their applications the mechanical stability and performance is an important aspect. Here, we use a computational approach involving a density-functional based tight-binding method to calculate the in-plane elastic properties of about 40 COFs with a honeycomb lattice. Based on those calculations, we develop two coarse-grained descriptions: one based on a spring network and the second using a network of elastic beams. The models allow us to connect the COF force constants to the molecular force constants of the linker molecules and thus enable an efficient description of elastic deformations. To illustrate this aspect, we calculate the deformation energy of different COFs containing the equivalent of a Stone-Wales defect and find very good agreement with the coarse-grained description.
description: 17 pages, 6 figures + supplementary information
(378) Robert Wilson Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(379) Jane Gilbert Hastie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(380) John Hastie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Barriers, enablers and initiatives for uptake of advance care planning in general practice: A systematic review and critical interpretive synthesis
Creators: name: Ward, Paul
Publisher: name: Torrens University Australia
Year: 2023
Subjects: Health equity

description: Objectives How advance care planning (ACP) is conceptualised in Australia including when, where and how ACP is best initiated, is unclear. It has been suggested that healthcare delivered in general practice provides an optimal setting for initiation of ACP discussions but uptake remains low. This systematic review and critical interpretive synthesis sought to answer two questions: (1) What are the barriers and enablers to uptake of ACP in general practice? (2) What initiatives have been used to increase uptake of ACP in general practice? Design A systematic review and critical interpretive synthesis of the peer-reviewed literature was undertaken. A socioecological framework was used to interpret and map the literature across four contextual levels of influence including individual, interpersonal, provider and system levels within a general practice setting. Setting Primary care general practice settings Data sources Searches were undertaken from inception to July 2019 across Ovid Medline, Cumulative Index to Nursing and Allied Health Literature, Scopus, ProQuest and Cochrane Library of systematic reviews. Results The search yielded 4883 non-duplicate studies which were reduced to 54 studies for synthesis. Year of publication ranged from 1991 to 2019 and represented research from nine countries. Review findings identified a diverse and disaggregated body of ACP literature describing barriers and enablers to ACP in general practice, and interventions testing single or multiple mechanisms to improve ACP generally without explicit consideration for level of influence. There was a lack of cohesive guidance in shaping effective ACP interventions and some early indications of structured approaches emerging. Conclusion Findings from this review present an opportunity to strategically apply the ACP research evidence across targeted levels of influence, and with an understanding of mediators and moderators to inform the design of new and enhanced ACP models of care in general practice. PROSPERO registration number CRD42018088838
Fostering gender equality and alternatives to violence: perspectives on a gender-transformative community mobilisation programme in rural South Africa
Creators: name: Kahn, K.
name: Peacock, D.
name: Treves-Kagan, S.
name: Pettifor, A.
name: Lippman, S.A.
name: Maman, S.
name: MacPhail, C.
name: Khoza, N.
name: Twine, R.
Publisher: name: Routledge
Year: 2020

description: Gender-based violence and violence against children are significant problems in South Africa. Community mobilisation and gender-transformative programming are promising approaches to address and reduce violence. A quantitative evaluation of One Man Can, a gender-transformative community mobilisation programme in South Africa, found mixed results in increasing gender-equitable behaviours and reducing violence. To better understand these findings, we analyse longitudinal qualitative data from community mobilisers, community members and community action teams, exploring individual and community-level factors that facilitate and hinder change. Interviews and focus groups were transcribed and analysed. Participants self-reported changes in their gender-equitable attitudes and use of violence as a result of participation in the programme, although some participants also reported opposition to shifting to a more gender-equitable culture. Facilitators to change included the internalisation of gender-transformative messaging and supportive social networks, which was buoyed by a shared vocabulary in their community generated by One Man Can. Because the programme targeted a critical mass of community members with gender-transformative programming, mobilisers and community action teams were held accountable by community members to model non-violent behaviour. Results reinforce the importance of addressing facilitators and barriers to change at both individual and community levels.
(373) John Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(377) John Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Correlates of ART Use Among Newly Diagnosed HIV Positive Adolescent Girls and Young Women Enrolled in HPTN 068
Creators: name: Selin, A.
name: Gómez-Olivé, F.X.
name: Kahn, K.
name: Pettifor, A.
name: Wright, M.
name: Kimaru, L.
name: Twine, R.
name: Filiatreau, L.M.
Publisher: name: Springer
Year: 2020

description: Despite expanded access to HIV treatment worldwide, poor HIV care outcomes persist among adolescent girls and young women (AGYW). This study was conducted among AGYW recruited from the HPTN 068 cohort who had sero-converted to HIV during the main trial between 2011 and 2014. The aim was to examine correlates of anti-retroviral treatment (ART) use. Log binomial regression was used to estimate the crude associations between social support, stigma, and HIV status disclosure and current ART use. Adjusted analyses were also conducted controlling for age and time since diagnosis. Seventy-nine AGYW were included in this analysis. Median age of participants was 20 (range: 17 to 24) and time since diagnosis ranged from 0.5 to 4.8 years (median = 2.1). Over 75% of AGYW (n = 60) had sought HIV care at some point, with the same number reporting previous disclosure of their sero-status. However, just 43% (n = 34) of participants were on treatment at the time of the interview. Over half of participants (n = 44; 55.7%) reported social support was available to them most or all of the time, and the median stigma score was 90 (range 80–113). Adjusted analyses found higher current ART use among those who had disclosed their status (adjusted prevalence ratio (aPR): 3.19; 95% confidence interval (CI) 1.09, 9.32; p = 0.0339) and those with lower scores on the disclosure concern sub-scale of the Berger HIV Stigma Scale (aPR: 0.88; 95% CI 0.79, 0.98; p = 0.0236). ART use among AGYW living with HIV and enrolled in HPTN 068 was low despite relatively high linkage to care during the trial. Interventions aimed at minimizing individuals’ concerns about disclosure and improving onward disclosure of one’s status could further improve ART utilization among AGYW living with HIV in South Africa.
COMPARATIVE-STUDY OF CHEMICAL COMPOSITION OF FLEXIBLE AND HARD PARTS OF CUTICLE IN 4 SPECIES OF SIPUNCULIDS
Creators: name: Vossfoucart, M. F.
name: Barzin, S.
name: Jeuniaux, C.
name: Bussers, J. C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1978

Abstract
A Quantum Simulator Based on Locally Controlled Logical Systems
Creators: name: Riera-Sàbat, Ferran
name: Sekatski, Pavel
name: Dür, Wolfgang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In a digital quantum simulator, basic two-qubit interactions are manipulated by means of fast local control operations to establish a desired target Hamiltonian. Here we consider a quantum simulator based on logical systems, i.e. where several physical qubits are used to represent a single logical two-level system to obtain enhanced and simple control over effective interactions between logical systems. Fixed, distance-dependent pairwise interactions between the physical qubits lead to effective interactions between the logical systems, which can be fully controlled solely by the choice of their internal state. This allows one to directly manipulate the topology and strength of effective interactions between logical systems. We show how to choose and generate the required states of logical systems for any desired interaction pattern and topology, how to perform arbitrary logical measurements, and how to obtain full control over single logical systems using only the intrinsic two-body interactions and control of individual physical qubits. This leads to a universal quantum simulator based on logical systems. We discuss the advantages of such a logical quantum simulator over standard ones, including the possibility to reach target topologies that are only accessible with large overheads otherwise. We provide several examples of how to obtain different target interaction patterns and topologies from initial long-ranged or short-ranged qubit-qubit interactions with a specific distance dependence.
description: (17 + 7) pages, (9 + 4) figues