cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Basal autophagy induction without AMP-activated protein kinase under low glucose conditions
Creators: name: Viollet, Benoit
name: Forsberg, Lawrence J.
name: Brenman, Jay E.
name: Williams, Tyisha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: When ATP levels in a cell decrease, various homeostatic intracellular mechanisms initiate attempts to restore ATP levels. As a prominent energy sensor, AMP-activated protein kinase (AMPK) represents one molecular gauge that links energy levels to regulation of anabolic and catabolic processes to restore energy balance. Although pharmacological studies have suggested that an AMPK activator, AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) may link AMPK activation to autophagy, a process that can provide short-term energy within the cell, AICAR can have AMPK-independent effects. Therefore, using a genetic-based approach we investigated the role of AMPK in cellular energy balance. We demonstrate that genetically altered cells, mouse embryonic fibroblasts (MEFs), lacking functional AMPK, display altered energy balance under basal conditions and die prematurely under low glucose-serum starvation challenge. These AMPK mutant cells appear to be abnormally reliant on autophagy under low glucose basal conditions, and therefore cannot rely further on autophagy like wild-type cells during further energetic stress and instead undergo apoptosis. This data suggests that AMPK helps regulate basal energy levels under low glucose. Further, AMPK mutant cells show increased basal phosphorylation of p53 at serine 15, a residue phosphorylated under glucose deprivation. We propose that cells lacking AMPK function have altered p53 activity that may help sensitize these cells to apoptosis under energetic stress.
Modulated escape from a metastable state driven by colored noise
Creators: name: Schuecker, Jannis
name: Diesmann, Markus
name: Helias, Moritz
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Many phenomena in nature are described by excitable systems driven by colored noise. The temporal correlations in the fluctuations hinder an analytical treatment. We here present a general method of reduction to a white-noise system, capturing the color of the noise by effective and time-dependent boundary conditions. We apply the formalism to a model of the excitability of neuronal membranes, the leaky integrate-and-fire neuron model, revealing an analytical expression for the linear response of the system valid up to moderate frequencies. The closed form analytical expression enables the characterization of the response properties of such excitable units and the assessment of oscillations emerging in networks thereof.
When the Late Victorian Period and YouTube Meet. A demonstration of digital media literacy
Creators: name: Danielson, Louisa
Publisher: name: Journal of Digital Media & Interaction
Year: 2023

description: Social media platforms allow digital and media literacy skills to be exercised before the public. Here, digital literacy is defined as a subset of media literacy. To use digital literacy as a subset of media literacy, a user utilizes three divisions of media usage as defined by Hoof and Boell and three spheres of digital literacy as outlined by Ng. Literacy, however, does not imply full social interaction; parasocial behaviors are part of the field. To demonstrate this, the genre of renovation/restoration videos on YouTube will be explored, with a focus on the channel The 2nd Empire Strikes Back.
description: Journal of Digital Media & Interaction, vol. 6 n.º 14 (2023): Meaning and Interaction
Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes
Creators: name: Currin, Robert T.
name: Lemasters, John J.
name: Rodriguez-Enriquez, Sara
name: Kai, Yoichiro
name: Maldonado, Eduardo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In primary culture, hepatocytes dedifferentiate, and their cytoplasm undergoes remodeling. Here, our aim was to characterize changes of mitochondria during remodeling. Hepatocytes were cultured one to five days in complete serum-containing Waymouth’s medium. In rat hepatocytes loaded with MitoTracker Green (MTG), tetramethylrhodamine methylester (TMRM), and/or LysoTracker Red (LTR), confocal microscopy revealed that mitochondria number and mass decreased by approximately 50% between Day 1 and Day 3 of culture. As mitochondria disappeared, lysosomes/autophagosomes proliferated five-fold. Decreased mitochondrial content correlated with (a) decreased cytochrome c oxidase activity and mitochondrial number observed by electron microscopy and (b) a profound decrease of PGC-1α mRNA expression. By contrast, mtDNA content per cell remained constant from the first to the third day of culture, although ethidium bromide (de novo mtDNA synthesis inhibitor) caused mtDNA to decrease by half from the first to the third culture day. As mitochondria disappeared, their MTG label moved into LTR-labeled lysosomes, which was indicative of autophagic degradation. A multiwell fluorescence assay revealed a 2.5-fold increase of autophagy on Day 3 of culture, which was decreased by 3-methyladenine, an inhibitor of autophagy, and also by cyclosporin A and NIM811, both selective inhibitors of the mitochondrial permeability transition (MPT). These findings indicate that mitochondrial autophagy (mitophagy) and the MPT underlie mitochondrial remodeling in cultured hepatocytes.
Unsupervised Network Pretraining via Encoding Human Design
Creators: name: Liu, Ming-Yu
name: Mallya, Arun
name: Tuzel, Oncel C.
name: Chen, Xi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Over the years, computer vision researchers have spent an immense amount of effort on designing image features for the visual object recognition task. We propose to incorporate this valuable experience to guide the task of training deep neural networks. Our idea is to pretrain the network through the task of replicating the process of hand-designed feature extraction. By learning to replicate the process, the neural network integrates previous research knowledge and learns to model visual objects in a way similar to the hand-designed features. In the succeeding finetuning step, it further learns object-specific representations from labeled data and this boosts its classification power. We pretrain two convolutional neural networks where one replicates the process of histogram of oriented gradients feature extraction, and the other replicates the process of region covariance feature extraction. After finetuning, we achieve substantially better performance than the baseline methods.
description: 9 pages, 11 figures, WACV 2016: IEEE Conference on Applications of Computer Vision
Preconceptional cardiovascular health and pregnancy outcomes in women with systemic lupus erythematosus
Creators: name: Eudy, A.M.
name: Engel, S.M.
name: Petri, M.
name: Howard, A.G.
name: Franceschini, N.
name: Clowse, M.E.B.
name: Siega-Riz, A.M.
Publisher: name: Journal of Rheumatology
Year: 2019

description: Objective. To estimate the effects of preconceptional cardiovascular (CV) health, measured by American Heart Association (AHA) guidelines, on pregnancy outcomes in women with systemic lupus erythematosus (SLE). Methods. The study included patients in the Hopkins Lupus Pregnancy Cohort. Body mass index (BMI), total cholesterol, and blood pressure (BP) in the most recent clinic visit prior to conception or first trimester were used to determine CV health (ideal, intermediate, or poor health) based on AHA definitions. Outcomes included preterm birth, gestational age at birth, and small for gestational age (SGA). Multivariable linear and logistic regression models with generalized estimating equations estimated the association of each CV health factor and outcome. Results. The analysis included 309 live births. There were 95 preterm births (31%), and of the 293 pregnancies with birth weights, 18% were SGA. Ideal BMI, total cholesterol, and BP were reported in 56%, 85%, and 51% of pregnancies, respectively. Intermediate BMI was associated with decreased odds of SGA (OR 0.26, 95% CI 0.11-0.63), adjusted for race and prednisone use. Intermediate/poor total cholesterol was associated with increased odds of preterm birth (OR 2.21, 95% CI 1.06-4.62). Intermediate/poor BP was associated with decreased gestational age at birth (β -0.96, 95% CI -1.62 to -0.29). Conclusion. Poor/intermediate preconception CV health affects pregnancy outcomes of preterm birth and SGA infants among women with SLE. Efforts to maintain BMI, total cholesterol, and BP within the recommended ideal range prior to pregnancy is important to improve pregnancy outcomes in women with SLE.
The Game Plants Make People Happy: Exploring Agency through Research-Creation
Creators: name: Chiapello, Laureline
Publisher: name: Journal of Digital Media & Interaction
Year: 2023

description: This research-creation delves into the concept of agency in video games. Recent studies have highlighted the importance of meaning-making in the experience of agency, and this work builds upon that research to argue that agency does not arise from a complex narrative structure nor from numerous interactions. Instead, agency arises from an exchange between players and the game situation, which includes the game world and the environment beyond the game, such as the game creators. The feeling of agency comes from a dialogue and transaction between the player and the world, which the game creators should foster. The video game Plants Make People Happy serves as an example of how such an exchange can take place, in an experience that leads the player to inexorable failure. Although at first the game may seem to remove all agency from the players, it actually enhances it by encouraging them to reflect on their relationship with the game creators.
description: Journal of Digital Media & Interaction, vol. 6 n.º 14 (2023): Meaning and Interaction
รูปแบบการจัดการศึกษาเพื่อพัฒนาคุณภาพชีวิตเด็กที่มีความต้องการจำเป็นพิเศษ ระดับปฐมวัย
Creators: name: วรพล  ธุลีจันทร์
Publisher: name: งานวารสาร มหาวิทยาลัยนครพนม
Year: 2023
Subjects: รูปแบบ
การจัดการศึกษา
คุณภาพชีวิต
เด็กที่มีความต้องการจำเป็นพิเศษ
ปฐมวัย

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยนครพนม, 13, 2, 163-176
AVANT Workshop "Antibiotic-free pork production: realiy or chimera?"
Creators: name: Guardabassi, Luca
name: Palzer, Andreas
name: Mikkelsen, Anne Stine
name: Buchet, Arnaud
name: Sialelli, Jean Noel
name: Nielsen, Jens Peter
name: Pedersen, Kasper
name: Rushton, Jonathan
Publisher: name: Zenodo
Year: 2024

description: The aim of the workshop organized by the EU Innovation Action AVANT is to facilitate dialogue and consensus on specific themes pertinent to the future of antibiotic-free pork production. The involvement of significant partners such as SEGES, COOPERL and FVE, alongside other relevant national and international stakeholders, will offer a diverse array of perspectives and expertise crucial for addressing the multifaceted challenges and opportunities of this type of production in the years to come. One significant outcome could be the development of a position paper encompassing the collective insights, agreements, and recommendations arising from the discussions held during the workshop.
The Game is Not Over. Relationships Between Ludic Appropriation and Production of Meaning in Video Games
Creators: name: Ferreira, Emmanoel
Publisher: name: Journal of Digital Media & Interaction
Year: 2023

description: This article discusses the relationships between ludic appropriation and the production of meaning in video games. By ludic appropriation, we refer to the act of performing in-game actions that were not designed or expected by the creators of a particular game, thus expanding the possibilities of producing meaningful interactions in this medium. This work is divided into three large blocks. First, we return to discussing particular aspects of games from theorists like Johan Huizinga, Roger Caillois, and Jacques Henriot. Next, we present the concepts of ludic freedom and ludic appropriation as developed by Maude Bonenfant. Finally, we analyze an episode of ludic appropriation by the community of players of Halo: Combat Evolved, seeking to exemplify, from a real case, the concepts worked throughout the text.
description: Journal of Digital Media & Interaction, vol. 6 n.º 14 (2023): Meaning and Interaction
The stakeholder-entrepreneur value creation pyramid in wine tourism: Taking supplier collaboration to the next level
Creators: name: Salvado, Josefina
name: Kastenholz, Elisabeth
name: Cunha, Diana
name: Cunha, Conceição
Publisher: name: Journal of Tourism & Development
Year: 2023

description: Wine tourism represents a complex ecosystem combining distinct sectors: grape production, wine making and tourism. Innovative wine tourism must understand the dynamics of the wine tourism ecosystem, specifically regarding entrepreneur-stakeholders' value-cocreation, and its capacity to unlock significant sources of new value, with benefits for all. By proposing a stakeholder-entrepreneur value-cocreation pyramid, the present study aims to explore how wine tourism companies model their own value constellation and what perceived benefits make them invest in partner/relationships yielding a win-win value cocreation, beneficial to all stakeholders involved. A qualitative methodology helped validate the proposed model, with data from wine tourism agents of the Bairrada wine route in Portugal, collected through 44 in-depth interviews. Content analysis was performed using NVivo12. From the stakeholder-entrepreneur view, interview results unmask a rather individualist and functional/ transactional attitude towards partners, revealing little relational/ truly collaborative/ societal engagement, hardly stimulating partners' co-creative potential. The proposed model provides an analytical framework for assessing the degree of cooperation and potential of innovative value-cocreation within the wine tourism ecosystem, thus reflecting stakeholders' relational maturity, and their ability to boost sustainable regional development through value-based and value-producing network dynamics.
description: Journal of Tourism & Development, vol. 43 (2023)
Genetic Variation of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam Shows Both Species-Specific and Spatiotemporal Associations
Creators: name: Emch, Michael
name: Carrel, Margaret
name: Wan, Xiu-Feng
name: Nguyen, Tung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Domestic poultry act as a reservoir for persistent H5N1 endemicity in Vietnam, and the circulation of poultry flocks across farms and to market is thought to drive the spatial movement and evolution of avian influenza viruses. Using a dataset of complete or nearly full genomic sequences from highly pathogenic H5N1 avian influenza viruses collected in domestic poultry in Vietnam from 2003 to 2007, we explore potential differences in genetic characteristics according to species of isolation and the spatio-temporal characteristics of the viruses. Clustering algorithms and analysis of variance indicate that H5N1 viruses in Vietnam show differences in the amount of genetic change that chicken viruses experience as compared to duck viruses, with duck viruses showing higher rates of molecular evolution on all eight of influenza's gene segments. There also exist distinct patterns of genetic differentiation according to the year in which they were isolated. These findings suggest that genetic evolution of avian influenza viruses is continuous through time but could also be mediated by the species in which the viruses occur, information which has implications for prevention efforts.
Emergence of inflationary perturbations in the CSL model
Creators: name: Leon, Gabriel
name: Bengochea, Gabriel R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The inflationary paradigm is the most successful model that explains the observed spectrum of primordial perturbations. However, the precise emergence of such inhomogeneities and the quantum-to-classical transition of the perturbations has not yet reached a consensus among the community. The Continuous Spontaneous Localization model (CSL), in the cosmological context, might be used to provide a solution to the mentioned issues by considering a dynamical reduction of the wave function. The CSL model has been applied to the inflationary universe before and different conclusions have been obtained. In this letter, we use a different approach to implement the CSL model during inflation. In particular, in addition to accounting for the quantum-to-classical transition, we use the CSL model to generate the primordial perturbations, that is, the dynamical evolution provided by the CSL model is responsible for the transition from a homogeneous and isotropic initial state to a final one lacking such symmetries. Our approach leads to results that can be clearly distinguished from preceding works. Specifically, the scalar and tensor power spectra are not time-dependent, and retains the amplification mechanism of the CSL model. Moreover, our framework depends only on one parameter (the CSL parameter) and its value is consistent with cosmological and laboratory observations.
description: 14 pages. Final version. To be published in EPJC
Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes
Creators: name: Methner, Carmen
name: Krieg, Thomas
name: Böckenholt, Thomas
name: Cuello, Friederike
name: Felix, Stephan B.
name: Zimmermann, Katrin
name: Müller, Tobias
name: Grube, Karina
name: Yang, Xiulan
name: Xu, Zhelong
name: Cohen, Michael V.
name: Downey, James M.
name: Rüdebusch, Julia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Protection achieved by ischemic preconditioning is dependent on A2B adenosine receptors (A2BAR) in rabbit and mouse hearts and, predictably, an A2BAR agonist protects them. But it is controversial whether cardiomyocytes themselves actually express A2BAR. The present study tested whether A2BAR could be demonstrated on rat cardiomyocytes.
Bayesian variable selection and computation for generalized linear models withconjugate priors
Creators: name: Kim, Sungduk
name: Ibrahim, Joseph G.
name: Chen, Ming-Hui
name: Huang, Lan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In this paper, we consider theoretical and computational connections between six popular methods for variable subset selection in generalized linear models (GLM’s). Under the conjugate priors developed by Chen and Ibrahim (2003) for the generalized linear model, we obtain closed form analytic relationships between the Bayes factor (posterior model probability), the Conditional Predictive Ordinate (CPO), the L measure, the Deviance Information Criterion (DIC), the Aikiake Information Criterion (AIC), and the Bayesian Information Criterion (BIC) in the case of the linear model. Moreover, we examine computational relationships in the model space for these Bayesian methods for an arbitrary GLM under conjugate priors as well as examine the performance of the conjugate priors of Chen and Ibrahim (2003) in Bayesian variable selection. Specifically, we show that once Markov chain Monte Carlo (MCMC) samples are obtained from the full model, the four Bayesian criteria can be simultaneously computed for all possible subset models in the model space. We illustrate our new methodology with a simulation study and a real dataset.
Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex
Creators: name: Meshnick, Steven R.
name: Moskalev, Nikolai V.
name: Trumpower, Bernard L.
name: Kessl, Jacques J.
name: Nasr, Mohamed
name: Gribble, Gordon W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Hydroxy-naphthoquinones are competitive inhibitors of the cytochrome bc1 complex that bind to the ubiquinol oxidation site between cytochrome b and the iron-sulfur protein and presumably mimic a transition state in the ubiquinol oxidation reaction catalyzed by the enzyme. The parameters that affect efficacy of binding of these inhibitors to the bc1 complex are not well understood. Atovaquone®, a hydroxy-naphthoquinone, has been used therapeutically to treat Pneumocystis carinii and Plasmodium infections. As the pathogens have developed resistance to this drug, it is important to understand the molecular basis of the drug resistance and to develop new drugs that can circumvent the drug resistance. We previously developed the yeast and bovine bc1 complexes as surrogates to model the interaction of atovaquone with the bc1 complexes of the target pathogens and human host.
การพัฒนาชุดกิจกรรมการเรียนรู้ด้วยตนเอง เรื่อง แนวคิดเชิงคำนวณ ตามแนวทาง SEASES Model เพื่อส่งเสริมทักษะการแก้ปัญหา สำหรับนักเรียนชั้นมัธยมศึกษาปีที่ 2
Creators: name: สุดารัตน์  วงศ์ยศ
Publisher: name: งานวารสาร มหาวิทยาลัยนครพนม
Year: 2023
Subjects: ชุดกิจกรรมการเรียนรู้ด้วยตนเอง
SEASES Model
ทักษะการแก้ปัญหา
แนวคิดเชิงคำนวณ
ปัญหาเป็นฐาน

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยนครพนม, 13, 2, 177-188
PaREM: A Novel Approach for Parallel Regular Expression Matching
Creators: name: Memeti, Suejb
name: Pllana, Sabri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Regular expression matching is essential for many applications, such as finding patterns in text, exploring substrings in large DNA sequences, or lexical analysis. However, sequential regular expression matching may be time-prohibitive for large problem sizes. In this paper, we describe a novel algorithm for parallel regular expression matching via deterministic finite automata. Furthermore, we present our tool PaREM that accepts regular expressions and finite automata as input and automatically generates the corresponding code for our algorithm that is amenable for parallel execution on shared-memory systems. We evaluate our parallel algorithm empirically by comparing it with a commonly used algorithm for sequential regular expression matching. Experiments on a dual-socket shared-memory system with 24 physical cores show speed-ups of up to 21x for 48 threads.
description: CSE-2014, Dec. 19th - 21st, 2014, Chengdu, Sichuan, China
การพัฒนาความคิดสร้างสรรค์ทางวิทยาศาสตร์ ด้วยการจัดการเรียนรู้ ตามแนวคิดสะตีมศึกษาโดยผลิตชิ้นงานจากวัสดุเหลือใช้
Creators: name: ประภาพร  เทียมเพ็ง
Publisher: name: งานวารสาร มหาวิทยาลัยนครพนม
Year: 2023
Subjects: ความคิดสร้างสรรค์ทางวิทยาศาสตร์
การจัดการเรียนรู้
สะตีมศึกษา
ชิ้นงานจากวัสดุเหลือใช้
ประสิทธิภาพ

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยนครพนม, 13, 2, 189-201
‘More than wine’. Wine routes as a strategic partnership for local development: The case of the Wine Route of Dionysus in Northern Greece
Creators: name: Partalidou, Maria
name: Tilkeridou, Dimitra-Kyriaki
Publisher: name: Journal of Tourism & Development
Year: 2023

description: Food and wine are part of our history and local identity that nowadays give floor to alternative forms of tourism achieving local sustainable development in rural areas and strategic partnerships. One tool available for rural destinations, bringing together a constellation of stakeholders, is the creation of wine routes. The purpose of the paper is to research collaborations between different stakeholders and evaluate the shared benefits of the creation of a wine route in the region of Drama, one of the most famous winemaking regions in Northern Greece. Using a qualitative research, and in-depth interviews with key stakeholders from the wine tourism ecosystem, such as local winemakers, representatives of rural tourism HORECA, experts from wine and tourism organizations and local development agencies, the paper tries to shed light to causes for non-participation in the wine route and the partnership managing the wine route, as well as to shared benefits from wine tourism in the area, perceived by those experts. From the results we see that people need to put on the table much more than just wine. They need to put trust, culture of cooperation, time, and resources for their strategic partnership to work towards inclusive, local and sustainable development. This is especially true in the post-covid-19 era, which is expected to give alternative forms of tourism and especially wine tourism, a promising future.
description: Journal of Tourism & Development, vol. 43 (2023)
ผลของการส่งเสริมการเรียนรู้เรื่อง การเลี้ยงลูกด้วยนมแม่สำหรับผู้เป็นสามีด้วยสิ่งแวดล้อมการเรียนรู้โดยอาศัยแพลตฟอร์มสื่อสังคมออนไลน์
Creators: name: ณัฐรัฐ  มูลมาตย์
Publisher: name: งานวารสาร มหาวิทยาลัยนครพนม
Year: 2023
Subjects: สิ่งแวดล้อมการเรียนรู้
แพลตฟอร์ม
การเลี้ยงลูกด้วยนมแม่
สื่อสังคมออนไลน์
การส่งเสริมการเรียนรู้

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยนครพนม, 13, 2, 202-215
Hydrachna simulans Marshall 1928
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydrachnidae
Hydrachna
Hydrachna simulans

description: Hydrachna simulans Marshall, 1928
New records: India, Assam State, Kamrup district, SW of Guwahati city, Deeper Beel wetland, between the water hyacinth Eichhornia corniculata, 26.10903N 91.68359E, 37 m asl., 3. iii. 2010, leg. Bordoloi, 10/0 (0/1/0 mounted); West Bengal, Malda district, Ravindrasarobar area, temporary pool, viii.2009, leg. Chatterjee, 1/1/0.
Records from the study area: Kerala—“ H. similis “ Cook (1967); Karnataka—“ H. mysorensis, H. kloomi “ Cook (1967); “ H. mysorensis, H. similis, H. kloomi “ Prasad (1974); West Bengal—Lundblad (1969).
Remarks: Lundblad (1969) synonymized Hydrachna similis Cook, 1967, H. mysorensis Cook, 1967 and H. kloomi Imamura, 1964 with H. simulans.
Habitat. Ponds, lakes.
Distribution: China, Thailand, India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on pages 4-5, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Temperature-dependent differences between readily releasable and reserve pool vesicles in chromaffin cells
Creators: name: Wightman, R. Mark
name: Siff, Lauren N.
name: Haynes, Christy L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Statistical differences between amperometric traces recorded from chromaffin cells using K+ and Ba2+ secretagogues support the assertion that readily releasable pool (RRP) and reserve pool (RP) vesicles can be probed with pool-specific secretagogues. Release from the RRP was evoked by K+ while release from the RP was evoked by Ba2+. Similar temperature-dependent changes in spike area and half-width for both pools suggest that the content of RRP and RP vesicles is similar and packaged in the same way. Differences between the vesicle pools were revealed in the temperature dependence of spike frequency. While the burst spike frequency of the RRP, which is comprised of pre-docked and primed vesicles, increased 2.8% per °C, the RP spike frequency increased 12% per °C. This difference is attributed to a temperature dependent mobilization of the RP. Furthermore, the RP exhibited more foot events at room temperature than the RRP but this difference was not apparent at 37°C. This trend suggests that RP vesicle membranes have a compromised surface tension compared to RRP vesicles. Collectively, the changes of release characteristics with temperature reveal distinctions between the RRP and the RP.
Comparative effectiveness of metformin versus insulin for gestational diabetes in New Zealand
Creators: name: Radke, S.
name: Engel, S.M.
name: Jonsson Funk, M.
name: Landi, S.N.
name: Boggess, K.
name: Stürmer, T.
name: Howe, A.S.
Publisher: name: John Wiley and Sons Ltd
Year: 2019

description: Purpose: To measure the comparative effectiveness of metformin versus insulin for initial pharmacological management of gestational diabetes mellitus (GDM). Methods: We conducted a population-based retrospective cohort study using administrative claims, maternity care, and laboratory result data from New Zealand. We followed pregnant women aged 15 to 45 from GDM diagnosis through delivery and assessed outcomes using maternity care and hospitalization data. We adjusted for covariates using inverse probability of treatment weights and multiple imputation for missing covariate information. We estimated unadjusted and adjusted risk ratios (RRs), risk differences (RDs) per 100, and 95% confidence intervals (CIs). Linear regression was used to estimate the association of treatment with birthweight. We stratified analyses by ethnicity and infant sex in prespecified sensitivity analyses. Results: We compared 3818 metformin-treated pregnancies with 3450 insulin-treated pregnancies. We observed differences in treatment initiation by ethnicity, socioeconomic status, region, and calendar year. Treatment groups were similar in age, body mass index (BMI), and timing of diagnosis/treatment initiation. After adjustment, metformin was associated with reduced absolute risk of planned elective c-section (RD = −2.3, 95% CI, −4.3 to −0.3), large for gestational age (RD = −3.7, 95% CI, −5.5 to −1.8), and neonatal hypoglycemia (RD = −5.0, 95% CI, −6.9 to −3.2) compared with insulin. There were no clinically meaningful differences in average birthweight between metformin- and insulin-treated pregnancies. We observed variation in estimates by ethnicity and infant sex for some neonatal outcomes. Conclusion: Metformin appears to be an effective treatment for women with GDM and may reduce risk of some adverse neonatal outcomes when compared with insulin.
Behaviour of circular chains of nonlinear oscillators with Kuramoto-like local coupling
Creators: name: Medina, K. García
name: Estevez-Rams, E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The conditions under which synchronization is achieved for a one-dimensional ring of identical phase oscillators with Kuramoto-like local coupling are studied. The system is approached in the weakly coupled approximation as phase units. Instead of global couplings, nearest-neighbor interaction is assumed. Units are pairwise coupled by a Kuramoto term driven by their phase differences. The system exhibits a rich set of behaviors depending on the balance between the natural frequency of isolated units and the self-feedback. The case of two oscillators is solved analytically, while a numerical approach is used for $N>2$. Building from Kuramoto, the approach to synchronization, when possible, is studied through a local complex order parameter. The system can eventually evolve as a set of coupled local communities towards a given phase value. However, the approach to the stationary state shows a non-monotonous non-trivial dynamic.
description: Revised version published in AIP Advances 13, 035222 (2023)
มาตรการทางกฎหมายเกี่ยวกับการคุกคามทางเพศโดยใช้คอมพิวเตอร์เป็นเครื่องมือในการกระทำความผิด
Creators: name: แพรวพรรณ เชี่ยวประสิทธิ์
Publisher: name: งานวารสาร มหาวิทยาลัยนครพนม
Year: 2023
Subjects: : มาตรการทางกฎหมาย
การคุกคามทางเพศ
คอมพิวเตอร์
เครื่องมือ
กระทำความผิด

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยนครพนม, 13, 2, 216-226
Complexity and transition to chaos in coupled Adler-type oscillators
Creators: name: Estevez-Moya, D.
name: Estevez-Rams, E.
name: Kantz, H.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: Coupled non-linear oscillators are ubiquitous in dynamical studies. A wealth of behaviors have been found mostly for globally coupled systems. From a complexity perspective, less studied have been systems with local coupling, which is the subject of this contribution. The phase approximation is used, as weak coupling is assumed. In particular, the so called needle region, in parameter space, for Adler-type oscillators with nearest neighbors coupling is carefully characterized. The reason for this emphasis is that in the border of this region to the surrounding chaotic one, computation enhancement at the edge of chaos has been reported. The present study shows that different behaviors within the needle region can be found, and a smooth change of dynamics could be identified. Entropic measures further emphasize the region's heterogeneous nature with interesting features, as seen in the spatiotemporal diagrams. The occurrence of wave-like patterns in the spatiotemporal diagrams points to non-trivial correlations in both dimensions. The wave patterns change as the control parameters change without exiting the needle region. Spatial correlation is only achieved locally at the onset of chaos, with different clusters of oscillators behaving coherently while disordered boundaries appear between them.
description: revised version published in PHYSICAL REVIEW E 107, 044212 (2023)
Maternal Thyroid Function during Pregnancy or Neonatal Thyroid Function and Attention Deficit Hyperactivity Disorder: A Systematic Review
Creators: name: Drover, S.S.M.
name: Villanger, G.D.
name: Zeiner, P.
name: Skogheim, T.S.
name: Aase, H.
name: Knudsen, G.P.
name: Longnecker, M.P.
name: Thomas Zoeller, R.T.
name: Engel, S.M.
name: Reichborn-Kjennerud, T.
Publisher: name: Lippincott Williams and Wilkins
Year: 2019

description: Background: Attention deficit hyperactivity disorder (ADHD) is the most common neurobehavioral disorder in children, yet its etiology is poorly understood. Early thyroid hormone disruption may contribute to the development of ADHD. Disrupted maternal thyroid hormone function has been associated with adverse neurodevelopmental outcomes in children. Among newborns, early-treated congenital hypothyroidism has been consistently associated with later cognitive deficits. Methods: We systematically reviewed literature on the association between maternal or neonatal thyroid hormones and ADHD diagnosis or symptoms. We searched Embase, Pubmed, Cinahl, PsycInfo, ERIC, Medline, Scopus, and Web of Science for articles published or available ahead of print as of April 2018. Results: We identified 28 eligible articles: 16 studies of maternal thyroid hormones, seven studies of early-treated congenital hypothyroidism, and five studies of neonatal thyroid hormones. The studies provide moderate evidence for an association between maternal thyroid hormone levels and offspring ADHD, some evidence for an association between early-treated congenital hypothyroidism and ADHD, and little evidence for an association between neonatal thyroid hormone levels and later ADHD. Conclusions: The reviewed articles suggest an association between maternal thyroid function and ADHD, and possibly between early-treated congenital hypothyroidism and ADHD. Study limitations, however, weaken the conclusions in our systematic review, underlining the need for more research. Importantly, there was much variation in the measurement of thyroid hormone function and of ADHD symptoms. Recommendations for future research include using population-based designs, attending to measurement issues for thyroid hormones and ADHD, considering biologically relevant covariates (e.g., iodine intake), and assessing nonlinear dose-responses.
Μακροχρόνιες μεταβολικές και καρδιοαγγειακές επιπλοκές σε γυναίκες με ιστορικό Σακχαρώδη Διαβήτη κύησης και Υπερτασικής νόσου κύησης
Creators: name: Ζαβού, Δήμητρα Γρηγορίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2025
Subjects: Μακροχρόνιες
Μεταβολικές και καρδιοαγγειακές επιπλοκές
Σακχαρώδης Διαβήτης κύησης και υπερτασική νόσο κύησης
Long-term
Metabolic and cardiovascular complications
Gestational Diabetes Mellitus and Hypertensive disease in pregnancy

description: Οι λόγοι πίσω από τον αυξημένο μακροπρόθεσμο κίνδυνο καρδιαγγειακών και μεταβολικών επιπλοκών σε γυναίκες με Σακχαρώδη διαβήτη κύησης και Υπερτασικής νόσου της κύησης είναι περίπλοκοι και περιλαμβάνουν την αλληλεπίδραση μεταξύ μεταβολικών, ορμονικών και ανοσολογικών μηχανισμών. Καθοριστικό ρόλο στην εμφάνισή τους διαδραματίζουν και η διατροφή, η άσκηση και ο τρόπος ζωής των γυναικών στην μετά την κύηση ζωής τους. Παθοφυσιολογικά οι μηχανισμοί εμφάνισης των μακροπρόθεσμων καρδιαγγειακών και μεταβολικών επιπλοκών είναι ακόμη σε μεγάλο βαθμό άγνωστοι και μια καλύτερη πρόγνωση του μακροπρόθεσμου καρδιαγγειακού και μεταβολικού κινδύνου που σχετίζεται με τον Σακχαρώδη Διαβήτη και την Υπέρταση που εμφανίζεται στην εγκυμοσύνη θα μπορούσε να επιτρέψει τη βελτίωση της αναγνώρισης των γυναικών που διατρέχουν μεγαλύτερο κίνδυνο και βελτιωμένες θεραπευτικές προσεγγίσεις που στοχεύουν στη μείωση του κινδύνου εμφάνισης αυτών των επιπλοκών μετά τον τοκετό.
description: The reasons behind the increased long-term risk of cardiovascular and metabolic complications in women with gestational diabetes mellitus and gestational hypertension are complex and involve the interplay between metabolic, hormonal and immunological mechanisms.The diet, exercise and lifestyle of women in their post-pregnancy life also play a decisive role in their appearance. Pathophysiological mechanisms of long-term cardiovascular and metabolic complications are still largely unknown and a better prognosis of long-term cardiovascular and metabolic risk associated with Diabetes Mellitus and Hypertension occurs in pregnancy could allow for improved identification of women at greater risk and improved therapeutic approaches aimed at reducing the risk of these postpartum complications.
Haefliger structures and symplectic/contact structures
Creators: name: Laudenbach, Francois
name: Meigniez, Gael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics

description: For some geometries including symplectic and contact structures on an n-dimensional manifold, we introduce a two-step approach to Gromov's h-principle. From formal geometric data, the first step builds a transversely geometric Haefliger structure of codimension n. This step works on all manifolds, even closed. The second step, which works only on open manifolds and for all geometries, regularizes the intermediate Haefliger structure and produces a genuine geometric structure. Both steps admit relative parametric versions. The proofs borrow ideas from W. Thurston, like jiggling and inflation. Actually, we are using a more primitive jiggling due to R. Thom.
description: To appear in Journal de l'Ecole Polytechnique
กระบวนการสร้างชุมชนการเรียนรู้ภูมิศาสตร์ กรณีศึกษา บ้านดงต้อง หมู่ 6 ตำบลผาตั้ง อำเภอสังคม จังหวัดหนองคาย
Creators: name: วิชญ์ จอมวิญญาณ์
Publisher: name: งานวารสาร มหาวิทยาลัยนครพนม
Year: 2023
Subjects: ชุมชนการเรียนรู้ภูมิศาสตร์
การจัดการองค์ความรู้
กระบวนการเรียนรู้ภูมิศาสตร์
แผนที่เดินดิน
ภูมิสารสนเทศ

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยนครพนม, 13, 2, 227-240
Wacana Etnodiplomatika Minangkabau
Creators: name: Hasanuddin Hasanuddin
Publisher: name: Figshare
Year: 2019
Subjects: subject: 130205 Humanities and Social Sciences Curriculum and Pedagogy (excl. Economics, Business and Management)
subject: FOS: Educational sciences
subject: 160502 Arts and Cultural Policy
subject: FOS: Political science
subject: 169903 Studies of Asian Society
subject: FOS: Sociology
subject: 200403 Discourse and Pragmatics
subject: FOS: Languages and literature

description: This paper reveals the construction of the typical Minangkabau ethnodiplomacy model? The construction of the model is elaborated on several main manuscripts, namely Tambo Alam Minangkabau and Kaba Cindue Mato. This study uses the perspective of Critical Discourse Analysis through text, intertext, and context studies. Theresults of the study show that Minangkabau Diplomacy is ideally constructed in a rational, tactical, confrontational, and accommodating scheme. However, in the practice of Paderi's diplomacy and Pasca PRRI, these bad faced challenges that caused traumatic socio-cultural effects, which had a profound impact on the joint lives of the Minangkabau people that have been felt to date.
Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation
Creators: name: Yanosky, J.D.
name: Fornage, M.
name: Whitsel, E.A.
name: Bressler, J.
name: Holliday, K.M.
name: Li, Y.
name: Assimes, T.L.
name: Horvath, S.
name: Bhatti, P.
name: Kennedy, E.
name: Cyrys, J.
name: Wolf, K.
name: Waldenberger, M.
name: Ward-Caviness, C.K.
name: North, K.E.
name: Brennan, K.J.M.
name: Liao, D.
name: Stewart, J.D.
name: Demerath, E.W.
name: Engel, S.M.
name: Guan, W.
name: Baldassari, A.
name: Méndez-Giráldez, R.
name: Justice, A.E.
name: Gondalia, R.
name: Hou, L.
name: Peters, A.
name: Pankow, J.S.
name: Conneely, K.N.
name: Jordahl, K.M.
name: Baccarelli, A.A.
Publisher: name: Elsevier Ltd
Year: 2019

description: Background: DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was to evaluate associations between DNAm and ambient concentrations of particulate matter (PM) ≤2.5, ≤10, and 2.5–10 μm in diameter (PM2.5; PM10; PM2.5–10). Methods: We conducted a methylome-wide association study among twelve cohort- and race/ethnicity-stratified subpopulations from the Women's Health Initiative and the Atherosclerosis Risk in Communities study (n = 8397; mean age: 61.5 years; 83% female; 45% African American; 9% Hispanic/Latino American). We averaged geocoded address-specific estimates of daily and monthly mean PM concentrations over 2, 7, 28, and 365 days and 1 and 12 months before exams at which we measured leukocyte DNAm in whole blood. We estimated subpopulation-specific, DNAm-PM associations at approximately 485,000 Cytosine-phosphate-Guanine (CpG) sites in multi-level, linear, mixed-effects models. We combined subpopulation- and site-specific estimates in fixed-effects, inverse variance-weighted meta-analyses, then for associations that exceeded methylome-wide significance and were not heterogeneous across subpopulations (P < 1.0 × 10−7; PCochran's Q > 0.10), we characterized associations using publicly accessible genomic databases and attempted replication in the Cooperative Health Research in the Region of Augsburg (KORA) study. Results: Analyses identified significant DNAm-PM associations at three CpG sites. Twenty-eight-day mean PM10 was positively associated with DNAm at cg19004594 (chromosome 20; MATN4; P = 3.33 × 10−8). One-month mean PM10 and PM2.5–10 were positively associated with DNAm at cg24102420 (chromosome 10; ARPP21; P = 5.84 × 10−8) and inversely associated with DNAm at cg12124767 (chromosome 7; CFTR; P = 9.86 × 10−8). The PM-sensitive CpG sites mapped to neurological, pulmonary, endocrine, and cardiovascular disease-related genes, but DNAm at those sites was not associated with gene expression in blood cells and did not replicate in KORA. Conclusions: Ambient PM concentrations were associated with DNAm at genomic regions potentially related to poor health among racially, ethnically and environmentally diverse populations of U.S. women and men. Further investigation is warranted to uncover mechanisms through which PM-induced epigenomic changes may cause disease.
Lavender fields in Spain. Tourism articulation of imaginaries from a Provençal Mediterranean oneiric
Creators: name: Ramírez-García, Susana
name: Gago-García, Cândida
name: Serrano-Cabronero, María Milagros
name: Babinger, Frank
name: Santander-Del-Amo, Fernando
Publisher: name: Journal of Tourism & Development
Year: 2023

description: Lavender tourism is known in countries such as France and England and is a growing activity in Turkey and East Asia. In Spain, however, this kind of tourism project is just beginning to emerge. Consequently, the literature on its scope and impact is also still in its early stages. This paper aims to explain the potential role of creativity and experiential activities in promoting lavender tourism, describe the structure of existing tourism products associated with Spanish lavender fields and elucidate the part these have played in economic diversification in rural areas, some of which are experiencing a severe rural exodus. These specific goals will contribute to a better understanding of the distinctive features of Spanish lavender field tourism and will help improve planning and management of its implementation in new territories.
description: Journal of Tourism & Development, vol. 43 (2023)
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
Creators: name: Johnson, Gary L.
name: Nakamura, Kazuhiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: c-Jun N-terminal kinases (JNKs), also referred to as stress-activated kinases (SAPKs), were initially characterized by their activation in response to cell stress such as UV irradiation. JNK/SAPKs have since been characterized to be involved in proliferation, apoptosis, motility, metabolism and DNA repair. Dysregulated JNK signaling is now believed to contribute to many diseases involving neurodegeneration, chronic inflammation, birth defects, cancer and ischemia/reperfusion injury. In this review, we present our current understanding of JNK regulation and their involvement in homeostasis and dysregulation in human disease.
Childbirth after adolescent and young adult cancer: a population-based study
Creators: name: Engel, S.M.
name: Luke, B.
name: Anderson, C.
name: Mersereau, J.E.
name: Nichols, H.B.
name: Black, K.Z.
name: Ruddy, K.J.
Publisher: name: Springer New York LLC
Year: 2018

description: Purpose: Annually, > 45,000 US women are diagnosed with cancer during adolescence and young adulthood (AYA). Since 2006, national guidelines have recommended fertility counseling for cancer patients. We examined childbirth after AYA cancer by calendar period, cancer diagnosis, and maternal characteristics. Methods: We identified a cohort of women with an incident invasive AYA cancer diagnosis at ages 15–39 during 2000–2013 in North Carolina. Cancer records were linked with statewide birth certificates through 2014. Hazard ratios (HR) and 95% confidence intervals (CI) for first post-diagnosis live birth were calculated using Cox proportional hazards regression. Results: Among 17,564 AYA cancer survivors, 1989 had ≥ 1 birth after diagnosis during 98,397 person-years. The 5- and 10-year cumulative incidence of live birth after cancer was 10 and 15%, respectively. AYA survivors with a post-diagnosis birth were younger at diagnosis, had lower stage disease, and had less often received chemotherapy than those without a birth. The 5-year cumulative incidence of post-diagnosis birth was 10.0% for women diagnosed during 2007–2012, compared to 9.4% during 2000–2005 (HR = 1.01; 0.91, 1.12), corresponding to periods before and after publication of American Society of Clinical Oncology fertility counseling guidelines in 2006. Conclusions: Despite advances in fertility preservation options and recognition of fertility counseling as a part of high-quality cancer care, the incidence of post-diagnosis childbirth has remained stable over the last 15 years. Implications for Cancer Survivors: Our study uses statewide data to provide recent, population-based estimates of how often AYA women have biological children after a cancer diagnosis.