cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From "Click" to "Click and Release", Using Inverse Electron Demand Diels-Alder Reaction for Chemical and Medicinal Applications
Creators: name: Wang, Danzhu
Publisher: name: Georgia State University
Year: 2014

description: Substituted tetrazines have been found to undergo facile inversed electron demand Diels-Alder reactions with ?tunable? reaction rates. By varying the substituents on tetrazine, cycloaddition rate variations of over 200 fold have been achieved with the same dienophile. Coupled with the availability of different dienophiles, such as norbornene, the reaction rate difference can be over 14,000 folds. These substituted tetrazines can be very useful for selective labeling under different conditions. This finding paves the way to utilize tetrazine conjugation reactions for not only DNA but also stage labeling work.
Carbon monoxide (CO) belongs to the gasotransmitter family of signalling molecules in the mammalian systems with importance on par with that of NO and H2S. Studies have shown that endogenous production of CO has anti-inflammatory, anti-proliferative, and anti-apoptotic effects in mammalian system. Besides of the conventional metal-based carbon monoxide releasing molecules (CORMs) to deliver CO for therapeutic purposes, organic CO prodrugs represent a new direction. Here we report the ?click and release? approached to release CO. Unlike the metal-based CORMs, our system does not contain transition metal and liberates CO with controllable manner and possesses potential tunable releasing rate property under physiological conditions.
EACS 2016 paper - Use of overturning spectra in the performance evaluation of on-off control strategies for rocking objects
Creators: name: Ceravolo, Rosario
name: Pecorelli, Marica
name: Fragonara, Luca Zanotti
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: EACS 2016 Paper No. 145
Rocking of rigid bodies induced by seismic events triggers a number of complex dynamic phenomena such as impacts, sliding, uplift, which can potentially result in disastrous outcomes. Typical structures that present a significant seismic vulnerability with respect to overturning are water tanks, electrical and hospital equipment, statues and art objects. Several methods have been investigated in the past years to prevent overturning or damage, such as rigid anchorage or base isolation devices. This paper presents some numerical investigations about a novel on-off adaptive control strategy for rigid blocks subjected to rocking motion. In more detail, control algorithms were specifically conceived to regulate an adjustable stiffness of two restrainers placed at the lower corners of the block. The control’s laws and the anchorage devices exhibited good performance when excited by simple one-sine pulse excitation, as reported by the authors in a previous study. The present work will instead investigate the performance and the robustness of the controlled system with respect to amplitude modulated harmonic excitations.
An investigation into the implementation and impact of literacy initiatives on disadvantaged primary schools in urban Ireland
Creators: name: Farrell, Elizabeth
Publisher: name: University of Lincoln
Year: 2024
Subjects: X320 - Academic studies in primary education

description: Background: In 2005, a national initiative was launched in Ireland, supporting designated schools in disadvantaged areas, known as Delivering Equality of Opportunity in Schools (DEIS). DEIS promotes national policy initiatives, with a major focus on increasing literacy levels, and diminishing the academic achievement gap of students in DEIS and non-DEIS schools.Purpose of Study: The study explored the process of implementation of new literacy initiatives in urban DEIS primary schools in Ireland. The study also examined the affect that literacy initiatives in DEIS schools had on educators through their engagement and professional development.The DEIS Initiative: The initiative supports DEIS schools to engage in school improvement, receiving additional financial support, extra teacher resources, after-school clubs and strategic planning support. DEIS primary schools implemented a suite of literacy initiatives, based on a phased delivery programme.Research Design: The research question was answered through a comparative multi-case- study approach. The study stemmed from an interpretative paradigm stance, rooted in the qualitative method, with the dominant instrument being semi-structured interviews. The learning experiences of nineteen educators in four urban DEIS primary schools and four DEIS advisors were collated. Other documentation, where available, supported and refined the triangulation of evidence.Findings: A theoretical ‘Knowledge Productivity in Literacy Framework’ emerged, encompassing a suite of three interconnecting components: infrastructure, professional learning and development, and stimulants for engagement. The study found that change needed to be (a) connected to the school’s vision and self-authored targets, (b) driven by key leaders in the school (c) amended and reflected upon through an iterative process, and (d) effectively communicated.Conclusion: This research identified key components that impact school improvement, with an emphasis on knowledge production in literacy and its management. The study investigated practices that supported critical educators, with the potential to make knowledge production dynamic. On a national level, the study’s findings can provide discussion opportunities for future literacy development.
EACS 2016 paper - Control of across-wind vortex shedding induced vibrations in tall buildings using the tuned mass-damper-inerter (TMDI)
Creators: name: Petrini, Francesco
name: Agathoklis Giaralis
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: EACS 2016 Paper No. 126
In this paper, the effectiveness of the tuned mass-damper-inerter (TMDI) vis-à-vis the classical tuned mass-damper (TMD) is assessed to suppress vortex shedding induced vibrations to tall building structures in the across-wind direction. The TMDI, previously proposed in the literature to mitigate earthquake-induced vibrations in multi-storey buildings, benefits from the mass amplification effect of the inerter (i.e., a two-terminal device developing a resisting force proportional to the relative acceleration of its terminals by the inertance constant) to achieve improved vibration suppression performance from the classical TMD for the same attached mass. Herein, a linear reduced-order structural system is developed, defined by a diagonal mass matrix and full damping and stiffness matrices, which captures faithfully the dynamic properties of a detailed finite element model corresponding to a benchmark 74-storey building with square floor plan. A TMDI is added to the structural system by elementary operations to the mass, damping, and stiffness matrices under the assumption of an ideal linear inerter. The wind action is represented by an analytical spectral density matrix modelling correlated across-wind induced forces accounting for vortex shedding and the structural analysis step is undertaken in the frequency domain for efficiency. A comprehensive parametric analysis is undertaken demonstrating that the TMDI achieves better performance in terms of peak top floor acceleration reduction with increasing inertance than a classical TMD with the same attached mass. This is also true for relatively small attached masses of practical interest to tall buildings (less than 0.5% the total buildings mass) for the case of peak top floor displacements. Further, it is shown that the TMDI reduces significantly the peak attached mass displacement, while the peak developing forces at the inerter are not excessive and can be locally accommodated by the building.
Materials in Germany’s domestic building stock: calculation model and uncertainties
Creators: name: Ortlepp, Regine
name: Gruhler, Karin
name: Schiller, Georg
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry

description: Building stocks are the dominant consumers of resources within national economies. Correspondingly, there is high demand for improved knowledge of material stocks and flows in the built environment. Material flow analysis is well suited to meet this demand. Although numerous studies have been conducted on this topic over recent years, these frequently lack applicability and transferability due to insufficient documentation or treatment of uncertainties. A new approach is presented here to calculate material stocks and flows for domestic buildings using the example of multi-family housing (MFH) in Germany. The approach is critically examined to determine its validity. The calculation process involves four steps: (1) building types are classified according to building age; (2) highly specific material composition indicators (MCIs) are calculated for the respective building types; (3) the total material stock as well as inflows and outflows are derived from the total floor space of Germany’s MFH; and (4) validity tests are performed to quantify uncertainties. The main results are age-based MCIs for MFH, the total material mass as well as quantitative information on parameter- and model-related uncertainties. Conclusions are drawn on the validity of results, the scalability and applicability of the model and its implementation, along with potential model refinements.
An investigation into the implementation and impact of literacy initiatives on disadvantaged primary schools in urban Ireland
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: X320 - Academic studies in primary education

description: Background: In 2005, a national initiative was launched in Ireland, supporting designated schools in disadvantaged areas, known as Delivering Equality of Opportunity in Schools (DEIS). DEIS promotes national policy initiatives, with a major focus on increasing literacy levels, and diminishing the academic achievement gap of students in DEIS and non-DEIS schools.Purpose of Study: The study explored the process of implementation of new literacy initiatives in urban DEIS primary schools in Ireland. The study also examined the affect that literacy initiatives in DEIS schools had on educators through their engagement and professional development.The DEIS Initiative: The initiative supports DEIS schools to engage in school improvement, receiving additional financial support, extra teacher resources, after-school clubs and strategic planning support. DEIS primary schools implemented a suite of literacy initiatives, based on a phased delivery programme.Research Design: The research question was answered through a comparative multi-case- study approach. The study stemmed from an interpretative paradigm stance, rooted in the qualitative method, with the dominant instrument being semi-structured interviews. The learning experiences of nineteen educators in four urban DEIS primary schools and four DEIS advisors were collated. Other documentation, where available, supported and refined the triangulation of evidence.Findings: A theoretical ‘Knowledge Productivity in Literacy Framework’ emerged, encompassing a suite of three interconnecting components: infrastructure, professional learning and development, and stimulants for engagement. The study found that change needed to be (a) connected to the school’s vision and self-authored targets, (b) driven by key leaders in the school (c) amended and reflected upon through an iterative process, and (d) effectively communicated.Conclusion: This research identified key components that impact school improvement, with an emphasis on knowledge production in literacy and its management. The study investigated practices that supported critical educators, with the potential to make knowledge production dynamic. On a national level, the study’s findings can provide discussion opportunities for future literacy development.
Accelerating Sustainable Housing Considering Occupants’ Health, Wellbeing and Thermal Comfort, the Case of Palestine
Creators: name: Alqadi, Shireen BA
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture

description: Energy security and affordability are among the major challenges facing the Palestinians. While the housing sector is a main energy consumer, the majority of the housing is of low energy efficiency. Before introducing the renewable energy technologies, optimizing the energy consumption is crucial. No up-to-date breakdown of energy consumption in the housing sector in Palestine is available at the time of writing this research. Meanwhile, very limited research incorporates the users’ behaviour alongside the physical characteristics of the buildings when examining the consumption of energy.The main goal of this research is to contribute to the development of sustainable housing in Palestine while considering thermal comfort, wellbeing and health of the users. The objectives of this research is to narrow the knowledge gap concerning the thermal performance of residential buildings and the thermal behaviour of the occupants. Another goal is to develop methods for estimating the energy consumption in buildings by integrating the socioeconomic characteristics of the occupants. In addition to critically assess the level of thermal comfort of occupants and develop adaptive models to predict the level of thermal comfort based on that. Finally, to create validated Dynamic Building Energy Simulation (DBES) models for existing case study buildings and integrate the users’ actual behaviour and thermal comfort preferences in the simulation to optimize the use of energy. Finally, the previous goals build together to produce a comprehensive framework to accelerate sustainable housing in Palestine that considers household wellbeing, safety and thermal preferences.The research adopted the research design using mixed methods approach. The research methods used were first the literature review, a multimode survey, comparative case study of 30 cases, semi structured interviews, monitoring and thermal simulation. The research revealed that not only the physical characteristics determine the energy consumption but also the thermal behaviour is crucial. The main contribution to the body of knowledge is a set of data base concerning the heating and cooling (HC) energy in the housing sector, a set of tools that estimate the (HC) energy, a set of adaptive comfort models, validated simulation models incorporating and users’ behaviour and finally, a framework to accelerate the sustainable housing.
Trematode fauna (Platyhelminthes: Digenea) of some sea ducks wintering on the southern Baltic coast (NW Poland) – a general comparison
Creators: name: Rząd, Izabella
name: Jiljí Sitko
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: The common scoter Melanitta nigra, velvet scoter M. fusca and long-tailed duck Clangula hyemalis (Aves: Anatidae) are among the more abundant sea ducks on the southern coast of the Baltic in winter, but their parasitic trematode fauna (Platyhelminthes, Digenea) in this region is little known. The aim of this study, conducted in 2007–2009, was a general comparison of the trematode fauna of these ducks in NW Poland. The prevalence and intensity of trematode infection were 68.3% and 119.9 in common scoter (101 examined), 77.6% and 13.1 in velvet scoter (58 examined) and 70.6% and 23.7 in long-tailed duck (68 examined). The following trematodes were found: Diplostomum pungitii, Apatemon gracilis, Australapatemon minor, Typhlocoelum sisowi, Echinochasmus spinulosus, Echinoparyphium recurvatum, Psilostomum brevicolle, Psilotrema simillimum, Catatropis verrucosa, Notocotylus attenuatus, N. gibbus, Paramonostomum alveatum, Prosthogonimus ovatus, Levinseniella propinqua, Gymnophallus bursicola and Cryptocotyle concava. The common scoter differs from the velvet scoter and long-tailed duck in its statistically significantly higher prevalence of G. bursicola; from long-tailed duck in its higher prevalence and greater intensity of infection with P. alveatum; and from velvet scoter in its greater intensity of infection with C. concava. The velvet scoter is distinguished from the long-tailed duck by its greater intensity of infection with P. brevicolle, lower prevalence of L. propinqua and lower intensity of infection with C. concava. Links between the differences found and the biology and ecology of the hosts, as well as the means of transmission of the parasites, are also discussed.
Accelerating Sustainable Housing Considering Occupants’ Health, Wellbeing and Thermal Comfort, the Case of Palestine
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture

description: Energy security and affordability are among the major challenges facing the Palestinians. While the housing sector is a main energy consumer, the majority of the housing is of low energy efficiency. Before introducing the renewable energy technologies, optimizing the energy consumption is crucial. No up-to-date breakdown of energy consumption in the housing sector in Palestine is available at the time of writing this research. Meanwhile, very limited research incorporates the users’ behaviour alongside the physical characteristics of the buildings when examining the consumption of energy.The main goal of this research is to contribute to the development of sustainable housing in Palestine while considering thermal comfort, wellbeing and health of the users. The objectives of this research is to narrow the knowledge gap concerning the thermal performance of residential buildings and the thermal behaviour of the occupants. Another goal is to develop methods for estimating the energy consumption in buildings by integrating the socioeconomic characteristics of the occupants. In addition to critically assess the level of thermal comfort of occupants and develop adaptive models to predict the level of thermal comfort based on that. Finally, to create validated Dynamic Building Energy Simulation (DBES) models for existing case study buildings and integrate the users’ actual behaviour and thermal comfort preferences in the simulation to optimize the use of energy. Finally, the previous goals build together to produce a comprehensive framework to accelerate sustainable housing in Palestine that considers household wellbeing, safety and thermal preferences.The research adopted the research design using mixed methods approach. The research methods used were first the literature review, a multimode survey, comparative case study of 30 cases, semi structured interviews, monitoring and thermal simulation. The research revealed that not only the physical characteristics determine the energy consumption but also the thermal behaviour is crucial. The main contribution to the body of knowledge is a set of data base concerning the heating and cooling (HC) energy in the housing sector, a set of tools that estimate the (HC) energy, a set of adaptive comfort models, validated simulation models incorporating and users’ behaviour and finally, a framework to accelerate the sustainable housing.
title: Attestation pour le patient no 79
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Lettre de Jacques Leibowitch résumant l'histoire du traitement anti-vih du patient, ayant pour but, une fois signée et approuvée, de servir d'attestation de leur consentement à emprunter une voie médicamenteuse non validée (allégée).
Budget impact of everolimus for the treatment of progressive, well-differentiated, non-functional neuroendocrine tumors of gastrointestinal or lung origin that are advanced or metastatic
Creators: name: Rose, Darya B.
name: Nellesen, Dave
name: Neary, Maureen P.
name: Beilei Cai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy

description: Background: Advanced neuroendocrine tumors (NETs) are a rare malignancy with considerable need for effective therapies. Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) in 2016 for treatment of adults with progressive, well-differentiated, non-functional NETs of gastrointestinal (GI) or lung origin that are unresectable, locally advanced, or metastatic. Objective: To assess the 3-year budget impact for a typical US health plan following availability of everolimus for treatment of GI and lung NETs. Methods An economic model was developed that considered two perspectives: an entire health plan and a pharmacy budget. The total budget impact included costs of drug therapies, administration, hospitalizations, physician visits, monitoring, and adverse events (AEs). The pharmacy model only considered drug costs. Results: In a US health plan with 1 million members, the model estimated 66 patients with well-differentiated, non-functional, and advanced or metastatic GI NETs and 20 with lung NETs undergoing treatment each year. Total budget impact in the first through third year after FDA approval ranged from $0.0568–$0.1443 per member per month (PMPM) for GI NETs and from $0.0181–$0.0355 PMPM for lung NETs. The total budget impact was lower than the pharmacy budget impact because it included cost offsets from administration and AE management for everolimus compared with alternative therapies (e.g. chemotherapies). Limitations: Because GI and lung NETs are rare diseases with limited published data, several assumptions were made that may influence interpretation of results. Conclusions: The budget impact for everolimus was minimal in this rare disease area with a high unmet need, largely due to low disease prevalence. These results should be considered in the context of significant clinical benefits potentially provided by everolimus, including significantly longer progression-free survival (PFS) for advanced GI and lung NET patients.
Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach
Creators: name: Rozaini Abdullah
name: Leolean Nyle Diaz
name: Wesseling, Sebastiaan
name: Rietjens, Ivonne M. C. M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: After the incidences of induction of aristolochic acid nephropathy after consumption of herbal weight loss preparations that accidentally contained aristolochic acids (AAs), several countries defined national restrictions on the presence of AAs in food, including plant food supplements (PFS) and herbal products. This study investigates whether the risks associated with exposure to AAs via PFS and herbal products are at present indeed negligible. Data reported in literature on AA levels in PFS and other herbal products and also obtained from a new series of PFS in the present study were used to calculate the estimated daily intakes (EDIs) and corresponding margins of exposure (MOEs). Available literature data revealed that 206 out of 573 samples were found to contain aristolochic acid I (AAI) and/or aristolochic acid II (AAII). The results obtained from recently collected PFS revealed that both AAI and AAII were detected in three out of 18 analysed PFS at levels up to 594.8 and 235.3 µg g–1, respectively, being in line with the levels reported in literature. The EDIs resulting from intake of these PFS resulted in MOEs that were generally below 10,000, corroborating the priority for risk management. Although these results refer to PFS collected by targeted sampling strategies, the data reveal that AA-containing PFS are still freely available. When considering that the use of these samples may be limited to shorter periods of time, the EDIs might be lower, but MOE values would still be lower than 10,000 for more than 50% of the AA-containing PFS and herbal products. In conclusion, the presence of AAs in PFS and herbal products even several years after instalment of the legal restrictions still raises concern, especially for people who frequently use the respective PFS and herbal products.
Glycosylation: Function, Synthesis and Application
Creators: name: Zhu, Hailiang
Publisher: name: Georgia State University
Year: 2018

description: Deamidation has been recognized as a common spontaneous pathway of protein degradation and its rate is sequence-dependent. Deamidation is a prevalent concern in pharmaceutical industry, causing the reduction of protein/peptide drug efficacy and shelf-life in several cases. Therefore, it is critical to discover means of controlling the deamidation rate of protein and peptide drugs. Deamidation of physiological proteins is also related to several human diseases, which is considered as a ?timer? for the diseases. In this thesis, it was demonstrated that deamidation is prevented by the naturally occurring glycosylation of Asn. All of the non-glycosylated peptides have different half-lives ranging from one to twenty days through incubation. Deamidation reaction was significantly reduced by the introduction of N-linked glycosylation.  RNase B was used to demonstrate that glycoprotein has elongated deamidation half-life than non-glycosylated protein RNase A. In this thesis, N-linked glycosylation was also applied on a therapeutic peptide and it was found that the N-linked glycosylation not only prevented its deamidation but also increased its potency.
SYNTHESIS: A cation exchange assisted binding-elution (BE) strategy for enzymatic synthesis of human milk oligosaccharides (HMOs) was developed.  An amino linker was used to provide the cation ion under acidic condition which can be readily bound to cation exchange resin and then eluted off by saturated ammonium bicarbonate. Ammonium bicarbonate in the collections was easily removed by vacuum evaporation.  This strategy circumvented the incompatible issue between glycosyltransferases and solid support or large polymers, and no purification was needed for intermediate products. With current approach, polyLacNAc backbones of HMOs and fucosylated HMOs were synthesized smoothly. His-tag facilitated enzymatic synthesis of oligosaccharides was developed for the purpose of automation of enzymatic synthesis of oligosaccharides. His-tag with six histine residues was successfully synthesized and enzymatic substrates were conjugated onto his-tag with a squarate linker readily. Two examples of oligosaccharides, polyLacNAc and Heparosan, were successfully synthesized to demonstrate this His-tag technology.
APPLICATION: A method of how to determine the oxidation degree of dextran as a drug carrier has been established. LNFPIII was successfully conjugated onto oxidized dextran with specific loading numbers by a double reduction amination reaction.
Adaptive ResNet Architecture for Distributed Inference in Resource-Constrained IoT Systems
Creators: name: Mazhar, Fazeela
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 40
subject: Engineering

description: As deep neural networks continue to expand and become more complex, most edge devices are unable to handle their extensive processing requirements. Therefore, the concept of distributed inference is essential to distribute the neural network among a cluster of nodes. However, distribution may lead to additional energy consumption and dependency among devices that suffer from unstable transmission rates. Unstable transmission rates harm real-time performance of IoT devices causing high latency, high energy usage, and potential failures. Hence, for dynamic systems, it is necessary to have a resilient DNN with an adaptive architecture that can downsize as per the available resources. This thesis presents an empirical study that identifies the connections in ResNet that can be dropped without significantly impacting the model’s performance to enable distribution in case of resource shortage. Based on the results, a multi-objective optimization problem is formulated to minimize latency and maximize accuracy as per available resources. Our experiments demonstrate that an adaptive ResNet architecture can reduce shared data, energy consumption, and latency throughout the distribution while maintaining high accuracy.
Kac–Moody symmetric spaces
Creators: name: Freyn, Walter
name: Hartnick, Tobias
name: Horn, Max
name: Köhl, Ralf
Publisher: name: Mathematisches Institut (Universität Münster)
Year: 2020
Subjects: subject: 510 Mathematics

description: In the present article we introduce and study a class of topological reflectionspaces that we call Kac–Moody symmetric spaces. These are associated with split realKac–Moody groups and generalize Riemannian symmetric spaces of noncompact split type.Based on work by the third-named author, we observe that in a non-spherical Kac–Moody symmetric space there exist pairs of points that do notlie on a common geodesic;however, any two points can be connected by a chain of geodesic segments. We moreoverclassify maximal flats in Kac–Moody symmetric spaces and study their intersection patterns,leading to a classification of global and local automorphisms. Some of our methods apply togeneral topological reflection spaces beyond the Kac–Moodysetting.Unlike Riemannian symmetric spaces, non-spherical non-affine irreducible Kac–Moodysymmetric spaces also admit an invariant causal structure.For causal and anti-causal geo-desic rays with respect to this structure we find a notion of asymptoticity, which allows usto define a future and past boundary of such Kac–Moody symmetric space. We show thatthese boundaries carry a natural polyhedral cell structureand are cellularly isomorphic togeometric realizations of the two halves of the twin buildings of the underlying split real Kac–Moody group. We also show that every automorphism of the symmetric space is uniquelydetermined by the induced cellular automorphism of the future and past boundary.The invariant causal structure on a non-spherical non-affineirreducible Kac–Moody sym-metric space gives rise to an invariant pre-order on the underlying space, and thus toa subsemigroup of the Kac–Moody group.We conclude that while in some aspects Kac–Moody symmetric spaces closely resembleRiemannian symmetric spaces, in other aspects they behave similarly tomasures, their non-Archimedean cousins
Predictors of treatment allocation guesses in a randomized controlled trial testing double-blind injectable hydromorphone and diacetylmorphine for severe opioid use disorder
Creators: name: Oviedo-Joekes, Eugenia
name: Marchand, Kirsten
name: Palis, Heather
name: Guh, Daphne
name: Brissette, Suzanne
name: Lock, Kurt
name: MacDonald, Scott
name: Harrison, Scott
name: Anis, Aslam H.
name: Krausz, Michael
name: Marsh, David C.
name: Schechter, Martin T.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: SALOME (Study to Assess Longer-term Opioid Medication Effectiveness) tested in a double-blind non-inferiority clinical trial if hydromorphone could be as effective as diacetylmorphine for severe opioid use disorder. Although participants did not guess treatment correctly beyond what is expected by chance, perceived treatment assignment could affect patients’ response to treatment. This study tested if treatment allocation guess is associated with treatment outcomes and identified predictors of guess. Methods: Data were obtained through questionnaires and clinical records. Participants were asked what medication they thought they were receiving (diacetylmorphine, hydromorphone or unsure) and their open-ended reasons. Multinomial logistic regression was used to assess the predictors of treatment guess. An inductive thematic analysis was used to code open-ended responses. This clinical trial was registered with U.S. National Institutes of Health (https://clinicaltrials.gov/ct2/show/NCT01447212). Findings: Participants referred to prior experiences with opioids and the presence or absence of specific drug effects as reasons for their guesses. There were no differences in illicit opioid use and retention by guess; however those who guessed diacetylmorphine had better physical and mental health scores. Participants with a treatment-related observed drowsiness event, and higher perceived drug-related high scores were more likely to guess diacetylmorphine compared to hydromorphone. Guessing hydromorphone was more likely among those who made negative comments as reasons for treatment guesses. Conclusions: Understanding the clues participants use for treatment allocation guesses and relating them to treatment expectations could be integrated with accurate information about the treatment, providing an opportunity for patient–physician shared decision-making in opioid maintenance treatment. Clinical trial registration: U.S. National Institutes of Health; ClinicalTrials.gov Identifier: NCT01447212; https://clinicaltrials.gov/ct2/show/NCT01447212
MPEC 2024-E12 : 2019 EM1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Whole-genome sequences of epiphytic Bacillus strains with biocontrol potentialities against the bacterial phytopathogen Erwinia amylovora
Creators: name: Frikha-Gargouri, Olfa
name: Ben Abdallah, Dorra
Publisher: name: Zenodo
Year: 2024

description: This study reports the complete and annotated genome assemblies of two epiphytic strains originating from pear and apple trees: Peribacillus frigoritolerans P.F1 and Bacillus paralicheniformis PF12. These strains exhibit antibacterial activities against Erwinia amylovora. Whole Genome Sequencing (WGS) was used for sequencing which is a valuable strategy to characterize Bacillus strains and provides insights into biocontrol mechanisms.
A new approach for teaching programming: model-based agile programming (MBAD)
Creators: name: Telesko, Rainer
name: Spahic, Maja
name: Hinkelmann, Knut
name: Pande, Charuta
Publisher: name: ACM
Year: 2023
Subjects: subject: 330 - Wirtschaft

description: Designing courses for introductory programming courses with a heterogeneous audience (business and IT background as well) is a challenging task. In an internal project of the School of Business at the FHNW University of Applied Sciences and Arts Northwestern Switzerland (FHNW) a group of lecturers developed a concept entitled “Model-based agile development” (MBAD) which supports the learning of elementary programming concepts in an agile environment and builds the basis for advanced courses. MBAD will be used as a basic learning module for various Bachelor programs at the FHNW.
Supplementary Material for: Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects
Creators: name: Akizawa, T.
name: Tsubakihara, Y.
name: Nangaku, M.
name: Endo, Y.
name: Nakajima, H.
name: Kohno, T.
name: Imai, Y.
name: Kawase, N.
name: Hara, K.
name: Lepore, J.
name: Cobitz, A.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: Daprodustat (GSK1278863) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for treatment of anemia associated with chronic kidney disease (CKD). The effect of daprodustat in Japanese CKD patients with anemia has not been previously investigated. Methods: We evaluated the relationship between daprodustat dose and hemoglobin response in Japanese patients on hemodialysis (HD) with anemia in a 4-week, phase II, double-blind, placebo-controlled study. After interrupting their erythropoiesis-stimulating agent for between 2 and 8 weeks, subjects with hemoglobin 8.5-10.5 g/dL were randomized to placebo or daprodustat 4, 6, 8, or 10 mg orally once daily. Hemoglobin, erythropoietin (EPO), and vascular endothelial growth factor (VEGF) levels during therapy were evaluated. Results: Eighty-six of 97 randomized subjects completed the study. Mean baseline hemoglobin ranged from 9.68 to 9.92 g/dL across groups. After 4-week administration, mean hemoglobin changes were -0.28, -0.01, 0.54, and 0.97 g/dL in the 4, 6, 8, and 10 mg groups, respectively, as compared to -1.41 g/dL for placebo. Dose-dependent increase in plasma EPO concentration were observed up to 8 mg, with the 10 mg dose responses being similar to 8 mg. Plasma VEGF concentrations were minimally changed, even though 5 subjects treated with 6-10 mg reached EPO >500 mIU/mL. Conclusion: Daprodustat 4-10 mg once-daily produced dose-dependent increase in hemoglobin relative to placebo in Japanese HD subjects. The doses evaluated in the study have moderately increased endogenous EPO without changes in circulating VEGF levels.
Simultaneous edit-imputation and disclosure limitation for business establishment data
Creators: name: Kim, Hang J.
name: Reiter, Jerome P.
name: Karr, Alan F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: Business establishment microdata typically are required to satisfy agency-specified edit rules, such as balance equations and linear inequalities. Inevitably some establishments' reported data violate the edit rules. Statistical agencies correct faulty values using a process known as edit-imputation. Business establishment data also must be heavily redacted before being shared with the public; indeed, confidentiality concerns lead many agencies not to share establishment microdata as unrestricted access files. When microdata must be heavily redacted, one approach is to create synthetic data, as done in the U.S. Longitudinal Business Database and the German IAB Establishment Panel. This article presents the first implementation of a fully integrated approach to edit-imputation and data synthesis. We illustrate the approach on data from the U.S. Census of Manufactures and present a variety of evaluations of the utility of the synthetic data. The paper also presents assessments of disclosure risks for several intruder attacks. We find that the synthetic data preserve important distributional features from the post-editing confidential microdata, and have low risks for the various attacks.
FAIR Data and Software: A Carpentries-based workshop at TIB, Hannover
Creators: name: Leinweber, Katrin
name: Kraft, Angelina
name: Kuzak, Mateusz
name: Johnston, Luke
name: Hammitzsch, Martin
name: Förstner, Konrad
Publisher: name: Zenodo
Year: 2018
Subjects: FAIR Software
FAIR Data
Carpentries
Python
Git
GitHub
R

description: This workshop aimed to train junior scientists in implementing the FAIR principles for research data & software management & development. We want to help you identify similarities and differences between these two scientific objects and apply respectively appropriate good practices in preparing, publishing and archiving your work. It was a new, experimental workshop format that contextualises the highly practical lesson material from the Software and Data Carpentries with the FAIR principles. Find more details on TIBHannover.GitHub.io/2018-07-09-FAIR-Data-and-Software.
description: Editable versions of the slides are available on https://drive.google.com/drive/folders/1JO-0SjKw52ICbNSHZuqdXjdIZIrh3Alp.
Chemoenzymatic synthesis of glycoconjugates and their applications
Creators: name: Wang, Shuaishuai
Publisher: name: Georgia State University
Year: 2020

description: Glycans and glycoconjugates play pivotal roles in biology process, due to the diversity of glycans and the high complexity of glycan linkages, the obtains of glycan and glycoconjugates hinder the study of those structures. This work mainly focused on the synthesis of glycans, glycopeptides. Additionally, the application of those glycans and glycoconjugates were also demonstrated.
O-mannosyl glycans account for up to 30% of total O-linked glycans in the mammalian brain and play critical roles in cellular interaction-based pathologies. An efficient base synthesis/enzymatic extension (BSEE) strategy was developed to synthesize 45 O-mannosyl glycans. A disaccharide and two tetra-saccharide base structures linked with an N-a-Fmoc-threonine were firstly prepared via convergent chemistry in gram scale, followed by enzymatic extension utilizing a panel of robust bacterial glycosyltransferases and HPLC-based separation to afford a library of structurally well-defined O-mannosyl glycans. Glycan microarray analysis of lectins, anti-glycan antibodies and anti-sera against such glycans revealed fine specificities of these glycan binding proteins (GBPs), including branch preferences, side-chain influences.
O-GalNAc glycans play pivotal roles in diverse biological processes and aberrant O-GalNAc glycosylation is highly associated with tumor growth and progression. Efficient methods to assemble structurally defined O-glycans are limited. Herein, we report a facile chemoenzymatic strategy to systematically access diverse O-GalNAc glycans library. Additionally, the first O-GalNAc glycans array platform was established by using those glycans. The binding profiles of various glycan binding proteins was investigated by this platform. This strategy paves the way for collective synthesis of O-GalNAc glycans and the O-glycan array provides an efficient and convenient platform for the characterize of O-glycan binding proteins.
Glycosylations of IgG antibodies are known to influence their functions in physiological and pathological conditions. Changes in the glycosylation pattern of IgG antibodies affect their biological activity. Human serum IgG contain a single N-glycosylation site in the constant region of their heavy chain, which is occupied by biantennary, predominantly core-fucosylated and partially truncated oligosaccharides. Rapid identification and quantification of those glycosylation is currently unsolved. Herein, we reported a rapid quantification strategy of serum Ig glycosylation by using isotope labelled glycopeptides.
Uncertainty quantification in image segmentation using the Ambrosio--Tortorelli approximation of the Mumford--Shah energy
Creators: name: Hintermüller, Michael
name: Stengl, Steven-Marian
name: Surowiec, ##!Error: Attribute  Unknown!##
Publisher: name: Weierstrass Institute
Year: 2020
Subjects: subject: Image segmentation
subject: Mumford-Shah
subject: Ambrosio-Tortorelli
subject: measurable selection
subject: Monte-Carlo
subject: sampling
subject: 62D99
subject: 65N75
subject: 68U10
subject: 65K10

description: The quantification of uncertainties in image segmentation based on the Mumford-Shah model is studied. The aim is to address the error propagation of noise and other error types in the original image to the restoration result and especially the reconstructed edges (sharp image contrasts). Analytically, we rely on the Ambrosio-Tortorelli approximation and discuss the existence of measurable selections of its solutions as well as sampling-based methods and the limitations of other popular methods. Numerical examples illustrate the theoretical findings.
We Are No Longer the Same: Saudi Female Doctoral Students and Saudi Third Culture Kids Studying in the UK and Returning Home
Creators: name: Al-Qahtani, Huda Ali Saeed
Publisher: name: University of Lincoln
Year: 2024
Subjects: C800 - Psychology

description: This research is the first to investigate the experiences of Saudi female international doctoral students accompanied by their families in the UK. It is also the first study to explore Saudithird culture kids’ (TCKs) and their mothers’ perspectives about their re-entry experiencesin the homeland. Using a qualitative approach and applying models of cross-culturalacculturation and adaptation, cultural dimensions and resilience, the research presents an in?depth exploration of varied aspects of participants’ adaptation and resilience, as well as thoseof their family companions. Also, the consequences of the cross-cultural experiences in the host and home countries were reported. Interviews were conducted in three studies and responses were analysed using thematic analysis. A systematic review of previous research was used to identify the research focus and sample for the first study which explored the experiences of Saudi female doctoral students while studying in the UK. In the second study,Saudi student-mothers shared their experiences of parenting and family life while studying in the UK. In the third study, the experiences of Saudi children after the families’ return to Saudi Arabia were explored through interviews with mothers and their children. Several individual and societal variables influenced the Saudi female students’ and their companions’ experiences in both the host and home countries. Key features across the threestudies were the central role of family, and religion in shaping the women’s adaptation andresilience. Family emerged as a subject of their concerns and challenges in home and host country, while also being perceived as a source of emotional and instrumental support. Religion and religious identity were strongly present in the women’s articulations of their personal strengths and positive experiences, and it aided them in achieving psychological and sociocultural adaptation. Both negative and positive consequences of the adaptation experiences in the host country were identified for the women, their spouses and children. These consequences were more apparent on the children than on their parents. Return to the VIhomeland highlighted the presence of a third culture identity in these children. As returnees, Saudi ‘third culture kids’ experienced several challenges in school as well as in social life. The implications of this research are beneficial to service providers, both in host and home countries, to improve services to support Saudi female students and their adult and child companions before, during, and after their cross-cultural journey.