cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Formulation of Poorly Water-Soluble Pharmaceutical Active Ingredients by Spray Drying using Three-Fluid Nozzle Atomization
title: Formulierung schwerlöslicher Arzneistoffe mittels Sprühtrocknung unter Verwendung einer Dreistoffdüse
Creators: name: Corell, Carolina
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2024

description: Poorly water-soluble drugs often require advanced formulation techniques to improve their solubility and to achieve the plasma concentration needed for a sufficient therapeutic effect upon oral administration. Amorphous formulations are an established strategy to improve oral delivery of poorly water-soluble drugs. The aim of this study was to overcome the limitations of the typical spray drying setup using a three-fluid nozzle to and to develop new formulation technologies. Amorphous solid dispersions (ASDs) were prepared using a three-fluid nozzle with two separate liquid feed solutions of (a) the active and (b) the polymer and compared to a typical two-fluid nozzle setup. The results showed that particles with the desired drug content could be manufactured using the three-fluid nozzle. ASDs with a drug load of up to 50% (w/w) were obtained processing solutions with miscible solvents and copovidone as polymer. Higher active concentrations, the use of immiscible solvents or switching of the capillaries led to a substantial crystallization of carbamazepine detected by x-ray powder diffraction and differential calorimetry analysis. New formulation technologies were investigated using calcium carbonate and various silicates as mesoporous carriers. For this purpose, amorphous samples were produced both by spray drying and by rotary evaporation. It was shown that mesoporous calcium carbonate could be produced in situ from sodium carbonate and calcium chloride in the spray dryer with the use of the three-fluid nozzle. The desired active ingredient content of 25% (w/w) was achieved in all samples, but depending on the preparation method used as well as the mesoporous carrier, a crystalline portion of active ingredient was found in the samples. Dissolution tests showed that the selected production method influenced the release rate. The spray dried samples released more active ingredient in a within 5 hours than the rotary evaporated samples. The three-fluid nozzle opens up new possibilities in the formulation of amorphous systems, but this work also revealed limitations of the nozzle.
Licht-Materie Wechselwirkung an Deponierten Molekülaggregaten und Freien Silber-Nanopartikeln
Creators: name: Hartmann, Hannes
Publisher: name: Universität Rostock
Year: 2016
Subjects: subject: 530 Physics

description: Der Fokus der Arbeit liegt auf Licht-Materie Wechselwirkungen auf Molerkülaggregaten und freien Silber-Nanopartikeln. Hier konnten durch Beugungsexperimente erstmals die dreidimensionalen Formen von individuellen freien Silber-Nanopartikeln bestimmt werden. Bei den Molekülaggregaten liegt der Schwerpunkt  auf Anregungsmechanismen und der Dynamik von Zuständen. Speziell werden hier die Unterschiede vom Kupfer-Porphyrin-Monomer zu den nanostrukturierten Aggregaten untersucht. Dabei  werden optische Methoden und PEEM (Photoemissions Elektronenmikoskopie) eingesetzt.
Application of FMEA Method towards Evaluation System of a Moroccan Engineering School
Creators: name: Ouzzine, Zhor
name: Laaroussi, Amina
name: Ajana, Souad
name: Bakkali, Soumia
Publisher: name: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION
Year: 2022
Subjects: quality, engineering, assessment, FMEA, learning outcomes..

description: This research paper aims to improving engineering training quality in Moroccan schools. It focuses on the learning assessment component that enables to evaluate the acquisition of the learned notions by the Moroccan engineering students. To achieve the purpose of this study, we analyzed the assessment in a Moroccan engineering school, and we established the process of evaluation. We then used the FMEA (Failure Modes and Effects Analysis) method to consider the process and suggest solutions that enables its improvement. We then recommended a monitoring plan, which enables the monitoring and control of the studied assessment process various steps. This present research aims at improving the engineering program quality and to give teachers and decision-makers the means to monitor the improvements made, particularly the students learning assessment. This work will also help to improve the accreditation of engineering schools to enable Moroccan diplomas to meet the international standards.
description: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION, Vol. 4, No 14 (2022)
Additional file 1 of Lived experience, social support, and challenges to health service use during the COVID-19 pandemic among HIV key populations in Indonesia
Creators: name: Sukmaningrum, Evi
name: Levy, Judith
name: Negara, Made Diah
name: Devika, Devika
name: Wardhani, Brigitta Dhyah K.
name: Wulandari, Luh Putu Lila
name: Januraga, Pande Putu
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplementary Material 1.
Contrôle de la pourriture des fruits d’agrumes en conservation au Maroc [Control of the rot of citrus fruit in conservation In Morocco]
Creators: name: ATTRASSI, Khaled
Publisher: name: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION
Year: 2022
Subjects: Agrumes, Pourriture, Azoxystrobine, Activité antifongique.

description: La conservation prolongée des fruits d’agrumes les expose à différentes affections qui peuvent être d’origine physiologique, souvent liées au froid, ou d’origine parasitaire, pour l’essentiel des maladies fongiques. Les résultats de l’identification ont abouti à la reconnaissance de quatre espèces fongiques, Penicillium italicum, Penicillium digitatum, Aspergillus niger et Acremonium sp. isolées des fruits d’agrumes en conservation dans la région de Kénitra au Maroc. Le pouvoir antifongique de l’azoxystrobine testées in vitro présente un large spectre d’action et possèdent une très forte activité antifongique sur la croissance diamétrale des agents pathogènes responsables de la pourriture des fruits d’agrumes.
description: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION, Vol. 4, No 14 (2022)
Les contingences culturelles africaines pendant la phase d’incubation du processus entrepreneurial
Creators: name: SONZAÏ, Théodore
Publisher: name: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION
Year: 2022
Subjects: Entrepreneuriat, Contingence culturelle, incubation

description: Le développement africain repose sur la capacité du continent à attirer des investisseurs étrangers dans des écosystèmes d’affaires favorables à la création d’entreprise. Toutefois, on cerne assez mal les déterminants du processus entrepreneurial essentiels à l’accompagnement des entreprises. Notre recherche tente d’éclairer cet aspect en analysant, par une approche hybride culturaliste et contingente, les facteurs qui influencent la phase d’incubation du processus entrepreneurial. Nos résultats, tirés de 102 entrepreneurs, révèlent que ceux-ci présentent un degré d’encastrement important au milieu familial, un système de croyance non rationnel et des temporalités courtes, s’éloignant des modèles occidentaux autonomistes et projectiviste. Ainsi, l’avenir de l’entrepreneuriat en Afrique passe nécessairement par des processus d’accompagnement qui englobent le champ communautaire, des spécificités culturelles différenciées et une formation à la projection dans le temps
description: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION, Vol. 4, No 14 (2022)
Effet des huiles essentielles sur la croissance diamétrale des moisissures responsable de la pourriture des fruits d’agrumes au Maroc
Creators: name: ATTRASSI, Khaled
Publisher: name: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION
Year: 2022
Subjects: Agrumes, activité antifongique, huiles essentielles, moisissures.

description: -La recherche de nouveaux produits phytosanitaires d’origine naturelle présentant moins de danger pour la santé humaine et à l’environnement est devenue une nécessité. Les huiles essentielles (HE), produites par certaines plantes possèdent des propriétés antimicrobiennes, peuvent contribuer à la lutte biologique contre la pourriture des fruits d’agrumes en conservation. Ainsi, nous avons isolées et identifiées à partir des fruits d’oranges pourris en conservation quatre espèces de Penicillium italicum, Penicillium digitatum, Acremonium sp. et d’Aspergillus niger ; ensuite l’activité antifongique des HE a été testée par les techniques de contact direct à montré une forte efficacité vis-à-vis de tous les champignons testés.
description: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION, Vol. 3, No 12 (2021)
Les facteurs institutionnels limitant l’accès des femmes à l’entrepreneuriat
Creators: name: JOUAD, Abir
name: MOUFDI, Nada
Publisher: name: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION
Year: 2022
Subjects: Entrepreneuriat ; femmes ; facteurs ; limitent ; monde entrepreneurial.

description: Dans les pays en développement, le taux de chômage est reconnu comme très élevé et les occasions de travail sont très faibles. L’entrepreneuriat peut parfois être la seule échappatoire possible à la pauvreté et plus particulièrement pour les femmes. En effet, dans ces pays, nombre de femmes qui se tournent vers une activité autonome, pas seulement pour avoir un revenu, mais comme le seul moyen possible de survie. En dépit des efforts déployés par le gouvernement et les décideurs, il est encore constaté que les femmes souffrent toujours des facteurs qui limitent leur accès au monde entrepreneurial. Dans ce sens, le présent article apportera une identification et une compréhension de ces facteurs.
description: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION, Vol. 3, No 12 (2021)
Additional file 4 of aMeta: an accurate and memory-efficient ancient metagenomic profiling workflow
Creators: name: Pochon, Zoé
name: Bergfeldt, Nora
name: Kırdök, Emrah
name: Vicente, Mário
name: Naidoo, Thijessen
name: van der Valk, Tom
name: Altınışık, N. Ezgi
name: Krzewińska, Maja
name: Dalén, Love
name: Götherström, Anders
name: Mirabello, Claudio
name: Unneberg, Per
name: Oskolkov, Nikolay
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 4. Review history.
L’intention entrepreneuriale des étudiants en Algérie.
Creators: name: AROUSSI, Miloud
Publisher: name: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION
Year: 2022
Subjects: Intention entrepreneuriale ; Algérie; Entrepreneuriat ; Diversification économique algérienne; éducation entrepreneuriale en Algérie

description: L’intention entrepreneuriale est un prédicteur probant de la création d’entreprise. En effet, avant toute création d’entreprise, il y a certainement une intention. C’est notamment ce que signifie la Théorie du Comportement Planifié d’Ajzen (1991). Compte tenu que très peu de recherches ont été effectuées à ce sujet pour ce qui concerne l’Algérie, nous avons choisi de réaliser cette recherche sur l’intention entrepreneuriale des étudiants de l’enseignement supérieur algérien. L’Algérie a un système d’enseignement supérieur public de 106 universités et écoles supérieures. Depuis 2007, 58 maisons de l’entrepreneuriat ont été mises en place sur l’ensemble du parc universitaire de l’enseignement supérieur public. Aussi, l’ONG Injaz El Djezaïr fournit un gros effort de sensibilisation et de formation auprès des étudiants des établissements de l’enseignement supérieur alors que le ministère du travail (gouvernement algérien) en partenariat avec l’Institut des nations unies pour la formation et la recherche (UNITAR) ont créé et développé depuis 2014/2015 (année de la première promotion) un programme d’accompagnement pour plus de 700 jeunes diplômés à l’entrepreneuriat. Ces jeunes diplômés ont à la suite du programme pour l'année universitaire 2014/2015, créé environ 750 jeunes nouvelles entreprises. De ce fait, nous avons, dans le cadre de cette première étude sur l’intention entrepreneuriale des étudiants en Algérie, réalisé une étude en 2 temps sur l’année universitaire 2014/2015 auprès d’un groupe de 120 étudiants de l’Université Mohamed Boudiaf de M’Sila (Centre-Est du pays), et ce à travers un questionnaire de 19 questions évaluées sur une échelle de Likert à 7 points et dont le traitement des données est présenté dans cet article. Il apparaît que l’intention entrepreneuriale des étudiants algériens de cette université est élevée. Aussi, le nombre de ces étudiants qui envisagent de créer une entreprise à l'obtention de leur diplôme ou plus tard est élevé également. Cette recherche vise à expliciter les travaux réalisés sur le sujet afin de dégager les premiers éléments de réponses sur l’intention d’étudiants algériens à créer une entreprise. A travers cette recherche, nous verrons dans un premier temps l’entrepreneuriat en Algérie depuis la réforme entreprise à la fin des années 1980, l’intention entrepreneuriale des étudiants algériens ainsi que l’apport de l’enseignement à l’entrepreneuriat dans le pays. Enfin, les résultats de la recherche seront détaillés ainsi qu’une discussion et des perspectives de recherches proposées.
description: REVUE DE L’ENTREPRENEURIAT ET DE L’INNOVATION, Vol. 3, No 12 (2021)
Ein generisches Objektmodell zum IT-unterstützten Lebenszyklusmanagement von Windkraftanlagen im Offshore-Bereich
Creators: name: Dietrich, Ute
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 620 Engineering & allied operations
subject: 004 Data processing Computer sciences

description: Offshore sind enorme Windressourcen, die sowohl ein großes Raumangebot als auch hohe Windgeschwindigkeiten miteinander verbinden. Eine erfolgreiche Durchführung dieser Projekte stellt, neben den umfangreichen Anforderungen an alle Beteiligten in Bezug auf Planung, Installation und Betrieb, auch hohe Erwartungen an eine durchgängige, lebensphasenübergreifende IT-Unterstützung. Die vielfältigen, komplexen Zusammenhänge werden innerhalb der Arbeit durch die lebenszyklusbasierte, integrierende Betrachtung aller relevanten Sichten und die Umsetzung als ein geeignetes Objektmodell abgebildet.
The Group of Companies Facing the Moroccan Insolvency Law: Overview and Perspective
Creators: name: Slamti, Miya
Publisher: name: International Social Sciences and management Journal
Year: 2022
Subjects: Group of companies; Moroccan law on companies in difficulty; Comparative Law; Collective Procedure; Confusion of assets and liabilities; Single jurisdiction; Coordinated procedure

description: The corporate group is a fundamental concept in business law. This concept has undergone considerable deployment in the national circle and beyond. The concept of the corporate group is of concern to all lawyers, but today it is of particular interest to specialists in the law of companies in difficulty. The notion of a group of companies seems to be neglected by this law, which takes refuge behind the idea that without legal personality there can be no collective proceedings. However, it would seem that the group concept is becoming established in insolvency law. The corporate group raises real problems and challenges for debtor company managers, but also for the legislative and judicial authorities. It would therefore be appropriate to take stock of the situation in this area and to propose reforms and recommendations with reference to comparative legislation.
description: International Social Sciences and management Journal, No 06 (2022): Le local et le global dans les espaces organisés
title: Intestinal epithelial HIF1α expression protects against necroptosis induced by arthritis
title: Die HIF1α-Expression im Darmepithel schützt vor der durch Arthritis ausgelösten Nekroptose
Creators: name: Lyu, Pang
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 0
Subjects: subject: DDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit

description: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, characterized by chronic synovitis, cartilage damage and bone erosion. Inflammation in the joints results from the influx of immune cells, which produce high amounts of pro-inflammatory cytokines. Based on the gut-bone axis theory, the role of gut homeostasis in arthritis onset and disease severity are receiving increasing attention. The intestine is not only a digestive organ, but also the largest immune detoxification organ of the body, which affects the immunity of the organism. The rise in systemic inflammation has been reported to be tied to the role of the gut as an immune organ. Intestine is a natural reservoir of bacteria, with billions of microorganisms that host in the intestine and help in the establishment of the immune system on the intestinal mucosal surface. Under physiological conditions, the intestinal blood supply is abundant and intestinal epithelial cells (IECs) are residing in a relatively oxygen-abundunt state. However, when inflammation strikes, it causes biological cellular hypoxia by consuming large amount of oxygen, and could activate hypoxia-inducible transcription factors (HIFs) expression. Previous work demonstrated that experimental model of arthritis could induce intestinal inflammation thus activating HIF2α expression. Inhibiting epithelial HIF2α could alleviate collagen-induced arthritis (CIA) by suppressing tight junction protein Claudin-15 (CLDN-15) expression. However, the role of HIF1α was unknown. HIF1α is reported to protect the intestine, by enhancing barrier function, strengthening immune function and antimicrobial response. Epithelial HIF1α deficient mice CIA showed an exacerbated phenotype of arthritis with increased cell death of the IECs. Interestingly, the increased cell death associated with HIF1α deletion was largely attributed to necroptosis due to elevated expression of receptor-interacting serine/threonine-protein kinase 3 (RIPK3). Moreover, oral administration of Roxadustat, a HIFs prolyl-hydroxylase (PHD) inhibitor, could protect IECs from death and alleviate experimental arthritis. We identified HIF1α as a repressor of RIPK3 at the transcriptional level. We also confirmed that GSK872 compound, a RIP3 kinase activity inhibitor, was effective against arthritis associated-intestinal inflammation. In conclusion, HIF1α is critical to maintain the gut barrier function by inhibiting IECs necroptosis via HIF1α-RIPK3 axis in experimental arthritis.
La société unipersonnelle : une création révolutionnaire en droit des sociétés
Creators: name: GUENBOUR, Saida
Publisher: name: International Social Sciences and management Journal
Year: 2022
Subjects: Société unipersonnelle, constitution, fonctionnement, gestion, contrôle.

description: Le paysage des sociétés est peuplé de sociétés pluripersonnelles. En effet, cette forme classique s’est révélée d’une grande capacité d’adaptation et a servi de technique privilégiée d’organisation juridique des entreprises. Mais avec le temps et suite à différentes raisons, l’avènement de la société unipersonnelle s’imposait avec acuité dans le monde des affaires. Cette forme de société a bouleversé les rites irréfragables du droit des sociétés aussi bien au niveau des règles générales qu’au niveau des règles spéciales de constitution et de fonctionnement. Dans ce cadre, plusieurs réformes législatives ont consacré différentes formes de sociétés unipersonnelles pour répondre aux exigences des investisseurs.
description: International Social Sciences and management Journal, No 06 (2022): Le local et le global dans les espaces organisés
Seasonal distribution of methane in the surface water and the water column of selected areas of the Baltic Sea
Saisonale Methanverteilung im Oberflächenwasser und der Wassersäule für ausgewählte Gebiete der Ostsee
Creators: name: Gülzow, Wanda
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 540 Chemistry & allied sciences

description: To observe long time changes of the greenhouse gas methane great efforts are made to determine its sources and sinks within a global atmospheric methane budget. Methane emissions from marine environments encounter large uncertainties due to the lack of data and adequate measuring facilities. In this thesis a new system is presented, which allows the continuous and autonomous measurement of methane and carbon dioxide in surface waters of the Baltic Sea. It permits measurements with an unrivaled spatio-temporal resolution and the identification of influencing parameters and processes.
Optimization of the Assessment and Rehabilitation of Old Landfills in Kuwait
Creators: name: Al-Ahmad, Mohammad
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 550 Earth sciences
subject: 360 Social services, association

description: The results derived from the monitoring programs designed and implemented in JLF site during this research can be adopted and applied in other landfills with similar contents. The implementation of the "in-situ aerobic stabilization" method is proved to be a very promising approach for the minimization of environmental effects as well as the safe reclamation of the landfilling areas which is about 3% of the total urban/municipal areas of Kuwait.
Statistische Analyse von Aktinfilamenten und Anpassungstests mit geschätzten Parametern
Creators: name: Liu, Bing
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 510 Mathematics

description: Die Wechselwirkung zwischen Zellen und Biomaterialien beeinflusst wesentlich die in den Zellen ausgebildete Filamentstruktur. Im ersten Teil der Arbeit werden statistische Tests zum Nachweis der Existenz einer Hauptwachstumsrichtung der Filamente konstruiert. Im zweiten Teil der Arbeit werden mit dem Ziel der Modellwahl durch eine neue Randomisierungstechnik Anpassungstests mit geschätzten Parametern konstruiert. Für den Cramer-von-Mises-Tests wird die explizite Form der asymptotischen Güte unter lokalen Alternativen angegeben.
Additional file 1 of The impact of the English calorie labelling policy on the energy content of food offered and purchased in worksite cafeterias: a natural experiment
Creators: name: Luick, Madison
name: Bandy, Lauren
name: Jebb, Susan A.
name: Pechey, Rachel
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
Routes to polysubstituted and condensed pyridines and diazines - utilization of 1,3-bielectrophiles and transition metal-based catalysis in ring synthesis/modification
Creators: name: Ostrovskyi, Dmytro
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 540 Chemistry & allied sciences

description: The present work aimed to study the potential of well-known synthetic strategies for the synthesis of imidazo[4,5-b]pyridine-derived (or 1-desazapurine-derived), purine-derived and benzimidazole-derived moieties and their modifications. This includes [3+3] cyclocondensations, inverse electron-demand Diels-Alder reaction, intramolecular palladium-catalyzed arylation. In addition, unprecedented method of synthesis of 4-trifluoromethylpyridines was developed, including scope limitation and theoretical mechanistic studies with DFT methods.
ZodiAq: An Isotropic Flagella-Inspired Soft Underwater Drone for Safe Marine Exploration
Creators: name: Mathew, Anup Teejo
name: Feliu-Talegon, Daniel
name: Adamu, Yusuf Abdullahi
name: Hmida, Ikhlas Ben
name: Armanini, Costanza
name: Stefanini, Cesare
name: Seneviratne, Lakmal
name: Renda, Federico
Publisher: name: arXiv
Year: 2025
Subjects: subject: Robotics (cs.RO)
subject: Applied Physics (physics.app-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The inherent challenges of robotic underwater exploration, such as hydrodynamic effects, the complexity of dynamic coupling, and the necessity for sensitive interaction with marine life, call for the adoption of soft robotic approaches in marine exploration. To address this, we present a novel prototype, ZodiAq, a soft underwater drone inspired by prokaryotic bacterial flagella. ZodiAq's unique dodecahedral structure, equipped with 12 flagella-like arms, ensures design redundancy and compliance, ideal for navigating complex underwater terrains. The prototype features a central unit based on a Raspberry Pi, connected to a sensory system for inertial, depth, and vision detection, and an acoustic modem for communication. Combined with the implemented control law, it renders ZodiAq an intelligent system. This paper details the design and fabrication process of ZodiAq, highlighting design choices and prototype capabilities. Based on the strain-based modeling of Cosserat rods, we have developed a digital twin of the prototype within a simulation toolbox to ease analysis and control. To optimize its operation in dynamic aquatic conditions, a simplified model-based controller has been developed and implemented, facilitating intelligent and adaptive movement in the hydrodynamic environment. Extensive experimental demonstrations highlight the drone's potential, showcasing its design redundancy, embodied intelligence, crawling gait, and practical applications in diverse underwater settings. This research contributes significantly to the field of underwater soft robotics, offering a promising new avenue for safe, efficient, and environmentally conscious underwater exploration.
description: 43 pages, including disclaimer page, pre-peer-review version of the manuscript, and supplementary material
Entwicklung und Anwendung eines Hochdurchsatz-Screenings zur Optimierung der biotechnologischen Butanolproduktion
Creators: name: Scheel, Michael
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 570 Life science

description: Steigerungen der Butanolproduktion von Clostridium acetobutylicum durch rationelles Metabolic Engineering führten bislang nur bedingt zum Erfolg. Da ein Phänotyp von vielen Parametern bestimmt wird, können inverse Strategien nützen. Voraussetzung für das inverse Metabolic Engineering ist eine Screening-Methode. Es wurde ein Assay entwickelt, um Alkohole in Kulturen von C. acetobutylicum messen zu können. Die Eignung des Screening-Systems wurde anhand zweier Beispiele evaluiert. Das Screening von Mutantenpopulationen führte zur Identifikation von Stämmen, deren Butanolbildung verbessert war.
Additional file 1 of Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
Creators: name: Quintela, Marcos
name: James, David W.
name: Pociute, Agne
name: Powell, Lydia
name: Edwards, Kadie
name: Coombes, Zoe
name: Garcia, Jetzabel
name: Garton, Neil
name: Das, Nagindra
name: Lutchman-Singh, Kerryn
name: Margarit, Lavinia
name: Beynon, Amy L.
name: Rioja, Inmaculada
name: Prinjha, Rab K.
name: Harker, Nicola R.
name: Gonzalez, Deyarina
name: Conlan, R. Steven
name: Francis, Lewis W.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Figures and Tables. Word document including Supplementary Figures S1-S7 and Supplementary Tables S1, S2.
Aldehyde in der Ausatemluft als Marker für Lungenkarzinome
Creators: name: Loeseken, Christian
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 610 Medical sciences Medicine

description: Durch eine alveolare Probennahme und einen Derivatisierungsschritt in der Phase der Präkonzentration (SPME-OFD) gelang ein zuverlässiger Nachweis von volatilen Aldehyden im Atemgas im Spurenbereich. In einer Studie mit 36 Teilnehmern konnten signifikante Unterschiede der Konzentration von Aldehyden im Atemgas zwischen Lungenkrebspatienten, gesunden Rauchern und gesunden Nicht-Rauchern festgestellt werden. Hinsichtlich Sensitivität und Spezifität sind diese Aldehyde mit den Serum-Tumormarkern CEA, NSE und Cyfra 21-1 vergleichbar. Kontaminationen mussten quantitativ berücksichtigt werden.
Factors affecting the result of matches in the one day format of cricket
Creators: name: BANDULASIRI, Ananda
name: BROWN, Tom
name: WICKRAMASINGHE, Indika
Publisher: name: Wrocław University of Technology, Wrocław University of Economics, Polish Operational and Systems Research Society
Year: 2016
Subjects: victory in a cricket match, efficient bowling, assignment problem, team sport

description: OPERATIONS RESEARCH AND DECISIONS; ISSN 2081-8858
sj-docx-1-sph-10.1177_19417381221084982 – Supplemental material for The Effects of Fatigue on Muscle Synergies in the Shoulders of Baseball Players
Creators: name: Thomas, Stephen J.
name: Castillo, Gabriel C.
name: Topley, Matthew
name: Paul, Ryan W.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine

description: Supplemental material, sj-docx-1-sph-10.1177_19417381221084982 for The Effects of Fatigue on Muscle Synergies in the Shoulders of Baseball Players by Stephen J. Thomas, Gabriel C. Castillo, Matthew Topley and Ryan W. Paul in Sports Health: A Multidisciplinary Approach
Untersuchungen zur Kinetik der Hydroformylierung mit Phosphit-modifizierten Rhodiumkatalysatoren unter Einsatz der in situ IR-Spektroskopie
Creators: name: Kubis, Christoph
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 540 Chemistry & allied sciences

description: Gegenstand der Arbeit waren Untersuchungen zu kinetisch-mechanistischen Aspekten der Hydroformylierung mit Phosphit-modifizierten Rhodiumkatalysatoren. Dafür wurde hauptsächlich die (HP)-in-situ-IR-Spektroskopie und die gaschromatographische Analytik eingesetzt. Weiterhin sind chemometrische Methoden und DFT-Rechnungen genutzt worden. Eine wesentliche Basis für die kinetische Analyse waren experimentell bestimmte Konzentrationsprofile der organischen Edukte und Produkte sowie der Katalysatorspezies.
Der Einfluss des Blut-Hirn-Schranken ABC-Transporters ABCC1 auf die Pathogenese der Alzheimer Demenz
Creators: name: Lange, Cathleen
Publisher: name: Universität Rostock
Year: 2012
Subjects: subject: 610 Medical sciences Medicine
subject: 590 Zoological sciences
subject: 570 Life science

description: Die Alzheimer Demenz gilt als häufigste Ursache für Demenzerkrankungen im höheren Lebensalter, mit stetig steigenden Patientenzahlen. Morphologisch gekennzeichnet ist die AD durch intrazerebrale Abeta-Akkumulationen. Der gestörte Export durch molekulare Transportmechanismen in diesem Zusammenhang ist bisher kaum untersucht. Eigens generierte AD-Mausmodelle identifizieren den ABC-Transporter ABCC1, mit Hauptexpression im Plexus choroideus, als entscheidenden Transporter in der AD-Pathogenese. Und zeigen, dass eine gezielte Aktivierung von ABCC1 zu einer Reduktion der Abeta-Akkumulation führt.
Bollettino Bibliografico - Bulletin Bibliographique COL III, 2, 2019, 439-443
Creators: name: Rozzi, Stefano
Publisher: name: Ciceroniana On Line
Year: 2021
Subjects: subject: Digital humanities
subject: Philology
subject: Latin language

description: Bibliography in Ciceroniana On Line. Publication about Cicero and Ciceronian studies from 01.01.2019 to 30.06.2019.
"The level happens"
Die (Sprach)ebene ergibt sich von selbst
Creators: name: Lueskow, Renée
Publisher: name: Universität Rostock
Year: 2016
Subjects: subject: 420 English

description: This qualitative study examines German non-NESTs’ perceptions of their foreign language skills, describing the language change they have observed since entering the profession. The research questions posed were whether the teachers notice differences, positive or negative, in their English after so many years of teaching, and, if so, if these differences affect them in any way. Data stem from semi-structured interviews, site visits, and can-do lists in which teachers were asked about how they learned English and how they evaluate their current levels as teachers and users of the language.
Stimulusinduzierte Wirkstofffreisetzung aus biokonjugierten implantatassoziierten Wirkstofffreisetzungssystemen auf Hydrogelbasis
Creators: name: Minrath, Ingo
Publisher: name: Universität Rostock
Year: 2016
Subjects: subject: 540 Chemistry & allied sciences

description: Das Potential von Polyacrylamid- und Polyacrylamid/Alginat-basierten biokonjugierten, Antigen/Antikörper-gekoppelten Hydrogelnetzwerken für die Verwendung als stimulusinduzierte, implantatassoziierte Hydrogelbeschichtung wurde untersucht. Abhängigkeit der Proteinpermeation von Größen wie dem Gelgehalt, der Gelarchitektur sowie dem Vernetzungsgrad der Hydrogelkörper betrachtet, die Implementierung der Antigene und Antikörper durchgeführt sowie die Haftfestigkeiten der Hydrogele auf Modellsubstratoberflächen untersucht.
Welchen Einfluss haben die arbeitsbezogenen Verhaltens- und Erlebensmuster der pädagogischen Fachkräfte, ihr Wissen und die Qualität der Kindertageseinrichtung auf die sozial-emotionale Entwicklung von Vorschulkindern?
Creators: name: Böhm, Julia
Publisher: name: Universität Rostock
Year: 2016
Subjects: subject: 370 Education

description: Im Rahmen der Professionalisierungsdebatte in der Frühpädagogik werden die Einflüsse fachkraftbezogener Determinanten auf der Ebene der sozial-emotionalen Kompetenzentwicklung von Vorschulkindern untersucht. Es werden die Unterschiede der Einschätzungen der sozial-emotionalen Kompetenzentwicklung in Abhängigkeit von dem arbeitsbezogenen Belastungserleben der Fachkräfte sowie die Zusammenhänge zwischen der kindlichen Kompetenzentwicklung und den fachkraftbezogenen Einflussfaktoren Arbeitsbelastung, Persönlichkeit, Fachwissen und Qualität der Kindertageseinrichtung betrachtet.
Additional file 1 of Patterns of enrichment and acceleration in evolutionary rates of promoters suggest a role of regulatory regions in cetacean gigantism
Creators: name: Silva, Felipe A.
name: Picorelli, Agnello C. R.
name: Veiga, Giovanna S.
name: Nery, Mariana F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1: Additional file 1: Table S1: Species used in this study and the respective accession numbers from NCBI; Figure S1: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the EGF gene. Numbers under nodes represent bootstrap support; Figure S2: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the GHSR gene. Numbers under nodes represent bootstrap support; Figure S3: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the IGF2 gene. Numbers under nodes represent bootstrap support; Figure S4: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the IGFBP2 gene. Numbers under nodes represent bootstrap support; Figure S5: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the IGFBP7 gene. Numbers under nodes represent bootstrap support; Figure S6: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the LCORL gene. Numbers under nodes represent bootstrap support; Figure S7: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the PLAG1 gene. Numbers under nodes represent bootstrap support; Figure S8: Maximum likelihood tree generated by IQ − TREE constructed from the promoter region of the ZFAT gene. Numbers under nodes represent bootstrap support; Figure S9: Enrichment pattern for the GHSR promoter implemented in the Ciiider program. The result shows transcription factors in bars. Mammals are cetaceans, artiodactyls, carnivores, primates, bats, and cingulates; Figure S10: Enrichment pattern for the IGF2 promoter implemented in the Ciiider program. The result shows transcription factors in bars. Mammals are cetaceans, artiodactyls, carnivores, primates, bats, and cingulates; Figure S11: Enrichment pattern for the IGFBP2 promoter implemented in the Ciiider program. The result shows transcription factors in bars. Mammals are cetaceans, artiodactyls, carnivores, primates, bats, and cingulates; Figure S12: Enrichment pattern for the LCORL promoter implemented in the Ciiider program. The result shows transcription factors in bars. Mammals are cetaceans, artiodactyls, carnivores, primates, bats, and cingulates; Figure S13: Enrichment pattern for the PLAG1 promoter implemented in the Ciiider program. The result shows transcription factors in bars. Mammals are cetaceans, artiodactyls, carnivores, primates, bats, and cingulates; Figure S14: Enrichment pattern for the ZFAT promoter implemented in the Ciiider program. The result shows transcription factors in bars. Mammals are cetaceans, artiodactyls, carnivores, primates, bats, and cingulates.
sj-docx-4-jic-10.1177_08850666221098383 - Supplemental material for Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients
Creators: name: Ammar, Mahmoud A.
name: Ammar, Abdalla A.
name: Wee, Timothy
name: Deshpande, Ranjit
name: Band, Matthew
name: Akhtar, Shamsuddin
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-4-jic-10.1177_08850666221098383 for Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients by Mahmoud A. Ammar, Abdalla A. Ammar, Timothy Wee, Ranjit Deshpande, Matthew Band and Shamsuddin Akhtar in Journal of Intensive Care Medicine
The development of new procedures for heterocycle synthesis under metal-free conditions
Creators: name: Feng, Jianbo
Publisher: name: Universität Rostock
Year: 2016
Subjects: subject: 540 Chemistry & allied sciences

description: This thesis mainly describes recent development in the synthesis of N- and O-containing heterocycles, which were conducted under transition-metal-free condition. A series of heterocycles like quinazolinones, quinazolinimines, quinazolinamines, aminoisoquinoline and dibenzoxazepinamines etc. were synthesized under transition-metal-free condition as presented in this thesis, which aims to provide a green, convenient and efficient methodology for the construction of the compounds bearing these units.
Micropropagation of Cactus Pear (Opuntia ficus indica) by Organogenesis
Creators: name: Bouchiha, Fatima
name: Mazri, Mouaad Amine
Publisher: name: African and Mediterranean Agricultural Journal - Al Awamia
Year: 2022
Subjects: Adventitious buds; in vitro; multiplication; tissue culture

description: The effects of different plant growth regulators (PGRs) on shoot development, adventitious bud induction, shoot bud multiplication, elongation and rooting were evaluated in cactus pear (Opuntia ficus indica). Shoot development from areoles was assessed on Murashige and Skoog (MS) medium containing different concentrations of 6-benzylaminopurine (BAP; 0-4 mg/l). Shoot segments were then cultured on the same initiation medium to induce adventitious buds. Adventitious shoot bud elongation and rooting were evaluated either on PGR-free MS medium, or on MS medium containing 0.5 mg/l of either 1-naphthalene acetic acid (NAA) or indole-3-butyric acid (IBA), and supplemented with different concentrations of gibberellic acid (GA3; 0.5-1 mg/l). Shoot development from areoles was achieved in all BAP-containing media (82.6-100%). Adventitious bud induction was 100% in all BAP-containing media, while the highest average number of adventitious buds per explant (21.0) was observed in MS medium containing 3 mg/l BAP, with no significant difference with those supplemented with BAP at 2 and 2.5 mg/l (16.4-20 buds per explant). Increasing BAP concentration to 4 mg/l significantly decreased the average number of buds per explant (5.3). Shoot elongation and rooting were better on PGR-free MS medium, which gave an average shoot length of 3.4 cm, 100% rhizogenesis, an average number of roots per shoot of 11.8 and a root length of 2.6 cm. The regenerated shoots were successfully acclimatized, with a survival rate of 81.25%. The established protocol can be used for the large-scale propagation of cactus pear in Morocco.
description: African and Mediterranean Agricultural Journal - Al Awamia, No 135 (2022)
sj-docx-6-jic-10.1177_08850666221098383 - Supplemental material for Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients
Creators: name: Ammar, Mahmoud A.
name: Ammar, Abdalla A.
name: Wee, Timothy
name: Deshpande, Ranjit
name: Band, Matthew
name: Akhtar, Shamsuddin
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-6-jic-10.1177_08850666221098383 for Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients by Mahmoud A. Ammar, Abdalla A. Ammar, Timothy Wee, Ranjit Deshpande, Matthew Band and Shamsuddin Akhtar in Journal of Intensive Care Medicine
IMPACT OF E-MAINTENANCE AND ARTIFICIAL INTELLIGENCE TOOLS ON COSTS AND BENEFITS
Creators: name: Moumen, Yassine
name: Benhadou, Mariam
name: Haddout, Abdellah
Publisher: name: Journal of Operations Management, Optimization and Decision Support
Year: 2022
Subjects: e-maintenance, maintenance, industry 4.0, costs, benefits.

description: In the current era, the market has extremely get developed, and the introduction of new technologies, and digitalization, AI… becomes a must. Indeed, only a few companies could be competitive nowadays in a digitized environment. This said, most companies today have introduced digitalization to all their strategic processes including maintenance as it’s considered as one of the development levers of many businesses since it has a direct impact on many key indicators i.e: costs, reliability, availability, safety, and productivity. Polemics about digitized maintenance have begun between the last decade of the previous century and the early 2000, it is commonly named “e-maintenance”. So far there is no standardized definition of the concept given by an official institution. Otherwise, as just a little attention was given to this subject in literature, this paper was written to give a global image of the impact of e-maintenance on costs and profit.
description: Journal of Operations Management, Optimization and Decision Support, Vol 2, No 2 (2022)
Synthese Kohlenhydrat-basierter Ionischer Flüssigkeiten für Anwendungen in der Medizintechnik
Creators: name: Reiß geb. Höfert, Melanie
Publisher: name: Universität Rostock
Year: 2016
Subjects: subject: 540 Chemistry & allied sciences

description: Der große Pool an natürlich vorkommenden Kohlenhydraten mit ihrer Vielfalt in Chiralität und Struktur führte zur Idee einer systematischen Untersuchung von Kohlenhydrat-basierten ILs. Dafür untersuchten wir den Einfluss von unterschiedlichen Ethergruppen, hauptsächlich von Methyl- oder Ethylether, an den sekundären OH-Gruppen und unterschiedliche Konfigurationen auf physikalische Eigenschaften wie Schmelzpunkt und den Einfluss auf die Zelltoxizität. Die synthetisierten ILs wurden auf ihre Eignung als Additiv in Beschichtungen für medizinische Anwendungen wie Drug-Eluting-Ballons geprüft.
Additional file 1 of Impacts of industrial actions, protests, strikes and lockouts by health and care workers during COVID-19 and other pandemic contexts: a systematic review
Creators: name: Craveiro, Isabel
name: Choudhury, Pradeep Kumar
name: de OLiveira, Ana Paula Cavalcante
name: Pereira, Alessandra
name: Fronteira, Inês
name: Chança, Raphael
name: Cometto, Giorgio
name: Poz, Mario Roberto Dal
name: Ferrinho, Paulo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1.
sj-docx-1-pie-10.1177_09544089221096052 - Supplemental material for Experimental studies on natural bank type heating/cooling energy saving Air conditioning system
Creators: name: Goyal, Vaishali
name: Asati, Arun Kumar
name: Garg, Rajeev Kumar
name: Arora, Amit
Publisher: name: SAGE Journals
Year: 2022
Subjects: Engineering not elsewhere classified
Materials Engineering not elsewhere classified

description: Supplemental material, sj-docx-1-pie-10.1177_09544089221096052 for Experimental studies on natural bank type heating/cooling energy saving Air conditioning system by Vaishali Goyal, Arun Kumar Asati, Rajeev Kumar Garg and Amit Arora in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Autonomy, Governance and Quality Assurance in Tunisia:‎ Case of Center of Biotechnology of Sfax
Creators: name: Choura, Abdallah
name: Kammoun, Raoudha
Publisher: name: Journal of Operations Management, Optimization and Decision Support
Year: 2022
Subjects: CBS, Quality, Environment, Security (QSE), governance, ‎continuous improvement, performance, Integrated System, ‎management.‎

description: The objective of this article is to prove that managerial practice in a ‎research structure can be strengthened through the establishment of ‎a results-oriented management mode (QSE & accreditation) and ‎the adoption of a sustainable system for planning, implementing, ‎and monitoring its strategy, as well as the development of a system ‎for continuously improving its performance.‎ Major governance changes associated with recognition through the ‎certification of the QSE system and accreditation of three analytical ‎parameters will strengthen the credibility regarding the socio-‎economic environment and the national, and international partners.‎
description: Journal of Operations Management, Optimization and Decision Support, Vol. 2, No 2 (2022)
La refonte du système de santé au Maroc à l’échelle régionale
Creators: name: Najdi, Adil
Publisher: name: Revue Marocaine de Santé Publique
Year: 2022
Subjects: Refonte; Systéme de Santé; Groupement de Santé Territoriel

description: La conception de la refonte du système de santé au niveau régional est d’une importance capitale vu la diversité des spécificités territoriales en termes des besoins, des ressources et des contraintes. Cette nouvelle conception régionale/territoriale du système de santé passe avant tout par l’adoption d’une nouvelle gouvernance visant à renforcer les mécanismes de régulation et de pilotage, ainsi qu’une refonte de la gouvernance hospitalière et la planification territoriale de l’offre sanitaire, en créant de nouveaux organes de gestion et de gouvernance dans le secteur de la santé : le GST (Groupement de Santé Territorial).
description: Revue Marocaine de Santé Publique, Vol. 9, No 14 (2022)