cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia
Creators: name: Suzuki, Hisashi
name: Hogg, James C.
name: Van Eeden, Stephan F.
Publisher: name: BioMed Central
Year: 2015

description: Background: Bone marrow (BM)-derived progenitor cells have been shown to have the potential to differentiate into a diversity of cell types involved in tissue repair. The characteristics of these progenitor cells in pneumonia lung is unknown. We have previously shown that Streptococcus pneumoniae induces a strong stimulus for the release of leukocytes from the BM and these leukocytes preferentially sequester in the lung capillaries. Here we report the behavior of BM-derived lineage negative progenitor cells (Lin- PCs) during pneumococcal pneumonia using quantum dots (QDs), nanocrystal fluorescent probes as a cell-tracking technique. Methods Whole BM cells or purified Lin- PCs, harvested from C57/BL6 mice, were labeled with QDs and intravenously transfused into pneumonia mice infected by intratracheal instillation of Streptococcus pneumoniae. Saline was instilled for control. The recipients were sacrificed 2 and 24 hours following infusion and QD-positive cells retained in the circulation, BM and lungs were quantified. Results Pneumonia prolonged the clearance of Lin- PCs from the circulation compared with control (21.7 ± 2.7% vs. 7.7 ± 0.9%, at 2 hours, P < 0.01), caused preferential sequestration of Lin- PCs in the lung microvessels (43.3 ± 8.6% vs. 11.2 ± 3.9%, at 2 hours, P < 0.05), and homing of these cells to both the lung (15.1 ± 3.6% vs. 2.4 ± 1.2%, at 24 hours, P < 0.05) and BM as compared to control (18.5 ± 0.8% vs. 9.5 ± 0.4%, at 24 hours, P < 0.01). Very few Lin- PCs migrated into air spaces. Conclusion In this study, we demonstrated that BM-derived progenitor cells are preferentially sequestered and retained in pneumonic mouse lungs. These cells potentially contribute to the repair of damaged lung tissue.
Supplementary Material from Vertically inherited microbiota and environment modifying behaviours conceal genetic variation in dung beetle life history
Creators: name: Rohner, Patrick T.
name: Moczek, Armin P.
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified
classificationCode: 310499
subject: Evolutionary biology not elsewhere classified
classificationCode: 3105
subject: Genetics
subject: FOS: Biological sciences

description: Supplementary figures and tables illustrating the experimental design and data structure.
Novel methods and strategies for microarray data analysis
Creators: name: Xiong, Huiling
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, General.
subject: Biology, Bioinformatics.

description: Microarray technology has been used as a routine high-throughput tool in biological research to characterize gene expression, and overwhelming volumes of data are generated in every microarray experiment as a consequence. However, there are many kinds of non-biological variations and systematic biases in microarray data which can confound the extraction of the true signals of gene expression. Thus comprehensive bioinformatic and statistical analyses are crucially required, typically including normalization, regulated gene identification, clustering and meta-analysis. The main purpose of my study is to develop robust analytical methods and programs for spotted cDNA-type microarray data. First, I established a novel normalization method based on the Generalized Procrustes Analysis (GPA) algorithm. I compared the GPA-based method with six other popular normalization methods, including Global, Lowess, Scale, Quantile, Variance Stabilization Normalization, and one boutique array-specific housekeeping gene method by using several different empirical criteria, and demonstrated that the GPA-based method was consistently better in reducing across-slide variability and removing systematic bias. In particular, being free from the biological assumptions that most genes (95%) are not differentially expressed on the array, the GPA method is therefore more robust, and appropriate for diverse types of array sets, including the boutique array where the majority of genes may be differentially expressed. Second, I utilized statistical analysis to assess the quality of a novel goldfish brain cDNA microarray, which provides statistical validation of microarray data result. Thirdly, I developed a new program suite as a user-friendly analytical pipeline integrating most popular analytical methods for microarray data analysis. Finally, I proposed a novel analytical strategy to extract season-related gene expression information from multiple microarray data sets by using comprehensive data transformation and normalization analysis, differential gene identification, and multivariate analysis.
Monika Kirloskar-Steinbach: Die Auseinandersetzung zwischen Liberalismus, Säkularismus und 'tolerantem Fundamentalismus’ im gegenwärtigen Indien
Creators: name: Lauschmann, Elisabeth
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 83 (2002): ASIEN (April)
Lives of White Dwarf Stars
Creators: name: Richer, Harvey
Publisher: name: The University of British Columbia
Year: 2016

description: White dwarf stars are the burnt out remnants that remain after a star like the Sun has completed its nuclear evolution. In such a star there are no remaining nuclear energy sources, so the star evolves by simply radiating its stored thermal energy out into space. This may seem rather uninteresting, but in fact there is a wealth of physical phenomena that occur during this part of a star's life - from getting kicked at birth, to neutrino emission in early life, to some interesting high density physics, through to functioning as precise clocks that can provide an age for some of the oldest know stars in the Universe. Some of these phases will be illustrated with detailed observations taken recently with the Hubble Space Telescope.
Covering arrays avoiding forbidden edges and edge clique covers
Creators: name: Maltais, Elizabeth
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Mathematics.

description: Covering arrays avoiding forbidden edges (CAFEs) are combinatorial designs which can be used to generate test suites for practical testing applications. CAFEs generate test suites in which all required pairwise interactions between any two factors are tested at least once each, with the property that a specified list of pairwise interactions, the so called forbidden interactions, are avoided by all tests generated by the CAFE. Consequently, CAFEs can be applied to testing applications wherein constraints are imposed on the factors of the tests, resulting in forbidden interactions. In this thesis, we study CAFEs, as well as their relationship to the edge clique cover problem from graph theory. We give new results and bounds for uniform edge clique covers and CAFEs. We establish the computational complexity of several problems related to CAFEs and edge clique covers. In particular, we prove that finding an optimal CAFE (as well as finding an optimal error-locating array) for a graph is NP-hard, even for the case of binary alphabets.
Cryptolopha burkii subsp. valentini Hartert
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Stenostiridae
Cryptolopha
Cryptolopha burkii
Cryptolopha burkii valentini hartert

description: Cryptolopha burkii valentini Hartert
 Cryptolopha burkii valentini Hartert, 1907e: 497 (Taipaischen).
 Now Seicercus valentini valentini (Hartert, 1907). See Alström and Olsson, 1999, Martens et al., 2003: 113, and Olsson et al., 2004.
 HOLOTYPE: AMNH 450459, adult male, collected on Taibai Shan (5 Taipaischen), 33.57N, 107.45E (BirdLife International, 2001: 2575), Qin Ling Shan (5 Tsin-ling Mountains), Shaanxi, China, on 2 June 1905, by collectors for Alan Owston (O.C. no. 132). From the Rothschild Collection.
 COMMENTS: Hartert (1907e: 497) noted that Berezowski and Bianchi incorrectly identified their Gansu birds with Cryptolopha tephrocephala (Anderson, 1871), thereby leaving them without a name. Hartert supplied Cryptolopha burkii valentini and designated the holotype by citing the specimen number 13205. This number has been written on the reverse of the Owston label and also on the Rothschild type label; it seems to be a combination of the Owston number and the year. All of the specimens of this form bear the Owston number 132, which may indicate the species.
 The range of the form was given as southern Gansu and Shaanxi (5 Süd-Kansu und Schensi) in the Qin Ling Shan (5 Tsinling-Gebirge). Paratypes in AMNH are AMNH 450456–450458 and 450460–450481, all collected by Owston’s collectors on Taibai Shan in the Qin Ling Shan. I did not find AMNH 450465 in the collection.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on pages 67-68, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
Bericht zur siebten Tagung des Münsteraner Asien-Pazifik-Forums (MAPF): "Die Philippinen zwischen Aufbruch und Abstieg"
Creators: name: Freistein, Katja
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 83 (2002): ASIEN (April)
Along-Valley Structure of Daytime Thermally Driven Flows in the Wipp Valley.
Creators: name: Rucker, Magdalena
name: Banta, Robert M.
name: Steyn, Douw G.
Publisher: name: American Meteorological Society
Year: 2011

description: High-resolution Doppler lidar observations obtained during the Mesoscale Alpine Program (MAP) 1999 field campaign are used to investigate the along-valley structure of daytime valley flows in the Wipp Valley, Austria. The observations show that under varying ambient conditions the valley flow increases in speed through a narrow section of the valley. Furthermore, the along-valley volume flux diverges along the valley segment under investigation, which suggests that the observed along-valley acceleration of the valley flow cannot be explained by the horizontal constriction of the valley sidewalls. It is hypothesized that the along-valley acceleration of the flow is caused by an intravalley change in the horizontal pressure gradient induced by differential heating rates of the valley atmosphere. Copyright 2008 American Meteorological Society (AMS). Permission to use figures, tables, and brief excerpts from this work in scientific and educational works is hereby granted provided that the source is acknowledged. Any use of material in this work that is determined to be “fair use” under Section 107 of the U.S. Copyright Act or that satisfies the conditions specified in Section 108 of the U.S. Copyright Act (17 USC §108, as revised by P.L. 94-553) does not require the AMS’s permission. Republication, systematic reproduction, posting in electronic form, such as on a web site or in a searchable database, or other uses of this material, except as exempted by the above statement, requires written permission or a license from the AMS. Additional details are provided in the AMS Copyright Policy, available on the AMS Web site located at (http://www.ametsoc.org/) or from the AMS at 617-227-2425 or copyright@ametsoc.org.
Functional and Structural Studies of the Anti- MinCD Domain of MinE
Creators: name: Hart, Christopher T
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Biochemistry.

description: The Min protein system, comprised of MinC, MinD and MinE, functions to ensure that the cytokinetic septum formed during bacterial binary fission is placed at midcell in gram negative bacteria. When bound to ATP, MinD binds to the cell membrane and recruits MinC, forming a complex which inhibits formation of the cell division septum. MinE plays a central role in the regulation of this process by opposing this inhibition through interactions with MinD that displace MinC and site-selectively permit formation of the cell division septum at midcell. However, the amino acid residues of MinE that are important for this interaction have yet to be delineated. In this thesis, I present data from an in vitro ATPase assay where I examined the ability of MinE mutant proteins from Neisseria gonorrhoeae ( N. gonorrhoeae), and synthetic peptides corresponding to the N-terminal amino acids of N. gonorrhoeae, to stimulate the ATPase activity of MinD from N. gonorrhoeae. The in vitro experimental data suggests that a sequence of five amino acids in the N-terminus of MinE plays a crucial role in MinE's ability to stimulate MinD ATPase activity and suggests that the N-terminal region of MinE is a functionally autonomous domain. To support the in vitro data, I also present preliminary data from an in vivo assay examining select MinE mutants. The preliminary in vivo experimental data supports the in vitro data, suggesting the importance of five amino acids in the N-terminus of MinE. Finally, I present spectroscopic data to complement my findings from both in vivo and in vitro assays. The results from this study have implications for all current theories regarding the mechanism by which MinE ensures that cell division occurs exclusively at midcell in gram negative bacteria.
Kambodscha im Internet - zwischen killing fields und cybercambodia
Creators: name: Wischermann, Jörg
name: Förster, Renate
name: Sander, Ingvar
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Wer Kambodscha-bezogene Ressourcen im Internet sucht und sich ahnungslos zu einem Besuch bei cybercambodia (http://www.cybercambodia.com/dachs) einladen lässt, wird erstaunt und vielleicht sogar schockiert sein.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 83 (2002): ASIEN (April)
СЕМЕЙНО-БЫТОВОЕ НАСИЛИЕ: ПОНЯТИЕ, ВИДЫ И ПРИЧИНЫ
Creators: name: Аллашова, Шийринай
Publisher: name: Zenodo
Year: 2024

description: Семейно-бытовое насилие — это социальное явление, представляющее собой умышленное и систематическое воздействие одного члена семьи на другого с целью подчинения или причинения вреда. В современном обществе семейно-бытовое насилие рассматривается не только как личная проблема внутри семьи, но и как серьёзное нарушение прав человека, требующее правового и социального вмешательства.
A wireless network of intelligent sensor agents for the mapping of multiple environmental parameters
Creators: name: Abielmona, Rami
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: The active investigation of complex environmental parameters involves many computationally intensive operations, such as data collection, aggregation, dissemination and processing. The adoption of multi-agent systems appears as a very promising approach in the development of a new generation of intelligent autonomous robotic agents for environment monitoring. This thesis discusses a multi-agent system whose global goal is the minimization of entropy of an environment, based on a novel tree-in-motion-mapping method. The proposed method combines simplicity and speed of computation, along with low storage and communications requirements, ideally fitting a system composed of a finite number of mobile robotic agents, each possessing limited sensing, processing and communicating operational entities. The method is also extensible to include multiple factors for the determination of the environmental entropy, hence allowing measurands such as electromagnetic, thermal and optical energies to be aggregated in the entropy function. Simulation results demonstrate the efficiency of the method, compare the centralized and decentralized approaches, and present the savings, both in processing and communication times, when compared to existing methods. Experimental results are presented and analyzed to validate the method in a testbed environment. Finally, a formal specification of a generic multi-agent system intended for environment monitoring is presented, while a virtual prototyping tool intended for verifying diverse scenarios in simulation, before proceeding to implementation, is outlined.
Paternal psychosocial work conditions and mental health outcomes: A case-control study
Creators: name: Maggi, Stefania
name: Ostry, Aleck
name: Tansey, James
name: Dunn, James
name: Hershler, Ruth
name: Chen, Lisa
name: Hertzman, Clyde
Publisher: name: BioMed Central
Year: 2016

description: Background: The role of social and family environments in the development of mental health problems among children and youth has been widely investigated. However, the degree to which parental working conditions may impact on developmental psychopathology has not been thoroughly studied. Methods: We conducted a case-control study of several mental health outcomes of 19,833 children of sawmill workers and their association with parental work stress, parental socio-demographic characteristics, and paternal mental health. Results: Multivariate analysis conducted with four distinct age groups (children, adolescents, young adults, and adults) revealed that anxiety based and depressive disorders were associated with paternal work stress in all age groups and that work stress was more strongly associated with alcohol and drug related disorders in adulthood than it was in adolescence and young adulthood. Conclusion: This study provides support to the tenet that being exposed to paternal work stress during childhood can have long lasting effects on the mental health of individuals.
Cryptolopha montis subsp. inornata Robinson and Kloss
Creators: name: LeCroy, M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Passeriformes
Stenostiridae
Cryptolopha
Cryptolopha montis
Cryptolopha montis inornata robinson and kloss

description: Cryptolopha montis inornata Robinson and Kloss
 Cryptolopha montis inornata Robinson and Kloss, 1920: 99 (Bandar Baroe, Deli, N.E. Sumatra).
 Now Seicercus montis inornatus (Robinson and Kloss, 1920). See van Marle and Voous, 1988: 180, and del Hoyo et al., 2006: 679.
SYNTYPES: AMNH 450574, male, and AMNH 450575, female, collected at Bandar Baru, 03.16N, 98.33E (BirdLife International, 2001: 2600), Deli region, northeastern Sumatra Island, Indonesia, on 26 December 1918, by A.F.C.A. van Heyst (nos. 1316 and 1317, respectively). From the Rothschild Collection.
 COMMENTS: Robinson and Kloss had only two specimens and designated them types (5 syntypes) in the original description, citing van Heyst’s field numbers. Both of the original labels are marked ‘‘ Cryptolopha montis inornata, R&K, Type’’. Hartert did not list this taxon in any of his lists of types in the Rothschild Collection, and I have found no indication that either specimen has been designated the lectotype, even though only the male bears a Rothschild type label. I have added an AMNH type label to the female and placed it in the AMNH type collection.
 Van Heyst (in Robinson and Kloss, 1920: 80) placed Bandar Baroe on the north side of Sumatra, ‘‘on the Medan-Toba road at the foot of Mt. Sibajak, at the entrance to the Tengkeh Pass. Birds collected there come from the north slopes of Mt. Sibajak, at a height of 1,000 –1,400 m’’. Mt. Sibayak (5 Mt. Sibajak) is at 03.15N, 98.30E, Utara Province (van Marle and Voous, 1988: 215). In the first part of their report on van Heyst’s collection, Robinson and Kloss (1919: map opp. p. 73) presented a map showing van Heyst’s localities. Van Marle and Voous (1988: 42) spelled the collector’s name ‘‘van Heijst’’, but on his field labels he spelled it van Heyst.
description: Published as part of LeCroy, M., 2008, Type Specimens Of Birds In The American Museum Of Natural History. Part 7. Passeriformes: Sylviidae, Muscicapidae, Platysteiridae, Maluridae, Acanthizidae, Monarchidae, Rhipiduridae, And Petroicidae, pp. 1-287 in Bulletin of the American Museum of Natural History 313 (1) on page 68, DOI: 10.1206/313.1, http://zenodo.org/record/13223808
title: High-resolution infrared spectra and rovibrational analysis of the v12 band of propylene oxide
Creators: name: Vávra, Karel
name: Döring, Eileen
name: Jakob, Jan
name: Peterß, Fabian
name: Kaufmann, Matin
name: Stahl, Pascal
name: Giesen, Thomas F.
name: Fuchs, Guido W.
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: 530
subject: 540
subject: 620
subject: Infrarotspektroskopie
subject: Vibrationsananlyse
subject: Propylenoxid

description: Gefördert im Rahmen des Projekts DEAL
The cultural evolution of socially situated cognition
Creators: name: Gabora, Liane
Publisher: name: Elsevier
Year: 2018

description: Because human cognition is creative and socially situated, knowledge accumulates, diffuses, and gets applied in new contexts, generating cultural analogs of phenomena observed in population genetics such as adaptation and drift. It is therefore commonly thought that elements of culture evolve through natural selection. However, natural selection was proposed to explain how change accumulates despite lack of inheritance of acquired traits, as occurs with template-mediated replication. It cannot accommodate a process with significant retention of acquired or horizontally (e.g. socially) transmitted traits. Moreover, elements of culture cannot be treated as discrete lineages because they constantly interact and influence one another. It is proposed that what evolves through culture is the mind; ideas and artifacts are merely reflections of its current evolved state. Interacting minds transform (in part) through through a non- Darwinian autopoietic process similar to that by which early life evolved, involving not survival of the fittest but actualization of their potential.
The characterization and regulation of the Akt isoforms in breast cancer
Creators: name: Santi, Stacey A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: Akt/PKB (protein kinase B) is a serine-threonine kinase involved in the regulation of many cellular processes, such as proliferation, metabolism, and cell survival. The elevated activation of the PI3K-Akt (phosphatidylinositol-3 kinase/Akt) pathway has been associated with tumor progression and increased tumour aggressiveness. Akt consists of three isoforms; Akt1, Akt2 and Akt3 (PKBalpha, PKBbeta, and PKBgamma, respectively) which share high similarity at the amino acid level (∼80%). Due to their similarity, it is generally assumed that the three isoforms regulate the same cellular processes, as well as signal to the same downstream substrates with similar preference. However, accumulating lines of evidence now suggest that the isoforms may regulate different cellular processes and are not functionally redundant. To further study the Akt isofonns and the role they play in the progression of tumorigenesis, a model of breast cancer (MDA-MB231 cell line) was employed. The Akt isoforms were first characterized through the examination of their subcellular localization to discern if differences in functional regulation can be inferred through their localization. The data obtained from this work demonstrated that isoforms displayed differential subcellular localizations. Specifically, Akt2 was found co-localized with the mitochondria, while Akt3 resided in the nucleus, thereby challenging the accepted notion that the isoforms are localized only in the cytoplasm. Next, studies were undertaken to determine which isoform is most important for cancer cell survival. Akt2 as found to be the most important isoform for survival in MDA-MB231 cells. Targeted ablation of each isoform using siRNA showed that Akt2 regulated cancer cell proliferation specifically by promoting cell cycle progression via the regulation of Cdk2, p27 and cyclin D. In addition, Akt2 ablation inhibited activation of the mTOR pathway through the downregulation of p70S6K. Prolonged inhibition of Akt2 altered mitochondrial morphology and eventually led to autophagy of the mitochondria (mitophagy). Collectively, the results of these studies impart a distinct role for Akt2 in cancer cell progression and survival and provide evidence that Akt2 may be a relevant target for future cancer therapies.
Where to go from now?
Creators: name: Schubert, Gunter
Publisher: name: Asien
Year: 2021

description: The re-election of Taiwan's Legislative Yuan on December 1st, 2001, had been awaited with much suspense both domestically and internationally. As all opinion surveys had indicated before, no political party was able to gain an absolute majority of votes. What kind of future government could be built, would depend on the relative gains and losses of the Guomindang (GMD) and the Democratic Progessive Party (DPP).
description: Asien, Nr. 83 (2002): ASIEN (April)
AIFA News about Clinical Trials in Italy for Covid-19
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2020
Subjects: Covid-10
AIFA

description: AIFA is providing information about the clinical trials for Covid-19 at the following link https://www.aifa.gov.it/sperimentazioni-cliniche-covid-19 , last update made on 14 May 2020. Here in the following some information given to update a discussion I made in "Drugs used in Italy against Covid-19", Zenodo. http://doi.org/10.5281/zenodo.3818234 The aim is that of include drugs not previously mentioned.
Kulturelle Identität der Region als Träger politischer Opposition im Staat
Creators: name: Vogt, Gabriele
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Die Renaissance der Friedensbewegung,die zwischen 1995 und 2000 die Inselpräfektur Okinawa überzog, trug in ihrem thematischen Kern den beabsichtigten Ausbruch der Präfektur aus den Fesseln ihrer nationalen Interdependenz. Okinawa berief sich, um der nationalen Regierung eine Verringerung der Verteidigungslasten der Präfektur abzutrotzen, auf seine eigene, historisch vom Pazifismus geprägte kulturelle Identität, die die Inselpräfektur deutlich von anderen Teilen Japans unterscheide.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 83 (2002): ASIEN (April)
Sozialstrukturelle cleavages, Wählerbindung und politische Repräsentation in Japan
Creators: name: Schmidt, Carmen
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Der Problemzusammenhang zwischen Sozialstruktur und politischer Ordnung gehört in den vergleichenden Sozialwissenschaften zu den klassischen Forschungsgebieten. Doch während westliche Gesellschaften häufig Gegenstand der Untersuchung waren, liegen zu Japan nur wenige ältere Studien vor. Dies gründet vor allem in der Popularität empirisch meist nicht überprüfbarer theoretischer Ansätze, die eine Einzigartigkeit und Homogenität der japanischen Gesellschaft behaupten und die Vergleichbarkeit mit westlichen Gesellschaften grundsätzlich verneinen .
description: ASIEN: The German Journal on Contemporary Asia, Nr. 83 (2002): ASIEN (April)
The effectiveness of intervention strategies to reduce motor vehicle crashes involving older drivers : systematic reviews and meta-analyses
Creators: name: Desapriya, Ediriweera
name: Subzwari, Sayed
name: Scime, Giulia
name: Pike, Ian, 1958-
Publisher: name: The University of British Columbia
Year: 2022

description: A systematic review of the current literature was undertaken to evaluate the efficacy of various intervention strategies for reducing the risk and rate of motor vehicle crashes (MVC) involving older drivers. Six different types of strategies which included: driver-related, vehicle-related, road infrastructure-related, clinical-related, legal- and policy-related, and screening strategies were assessed for effectiveness. Further, risk factors pertaining to older driver-related MVCs were researched. Based on the collective evidence, a plan has been formulated for a comprehensive final report of all the systematically searched publications for the period 1990 to 2007 related to older driver safety.
Strategien fur ein spillover des Diskurses unter Intellektuellen auf die Reformdebatte unter Politikern in Japan
Creators: name: Adelsberger, Karin
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: Zu Beginn der neunziger Jahre sah Japan sich mit diversen Problemen konfrontiert. Neben dem Ende des Ost-West-Konfliktes bewirkten auch der Zusammenbruch der Wirtschaft, die Enthüllung diverser Korruptionsskandale in Politik und Verwaltung, sowie das Versagen der Ministerialbürokratie bei mehreren Krisen eine breite gesamtgesellschaftliche Diskussion über das politische System Japans. Das so genannte '55er System' galt als gescheitert, man suchte nach Wegen, um die politökonomische Struktur Japans an die neuen nationalen und internationalen Gegebenheiten anzupassen. Die beiden großen politischen Reformen der neunziger Jahre, die Reform des Wahlsystems 1994 und die administrative Reform 1998, entstanden unter diesen Bedingungen.
description: ASIEN: The German Journal on Contemporary Asia, Nr. 83 (2002): ASIEN (April)
WMAP : Measuring how the universe began
Creators: name: Halpern, Mark
Publisher: name: The University of British Columbia
Year: 2017

description: The universe is filled with a thermal glow called the cosmic microwave background that comes from the hot plasma which filled it early on. Measurements of this background made by the NASA satellite WMAP have determined the age, geometry and composition of the universe with new precision, determining that the universe today is dominated by a dark energy that is causing it to expand ever more rapidly. The mission has also determined that baryonic matter--the atoms and molecules we see around us--only form a few percent of the total energy density of the universe today, and has determined the epoch at which the first stars formed. Recent results give a tantalizing picture of the first very small fraction of a second in the "big bang". Six years after its launch WMAP remains healthy and the data continue to pour in. This talk will explain to a general audience what this experiment tells us about how the universe began and what it is made out of.
Main group compounds with pi-conjugated nitrogen support: Carbenes, boranes, and guanidines
Creators: name: O'Brien, Julie S
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Chemistry, Organic.

description: This work focuses on the coordination and stabilization of unusual compounds and their chemistry, namely that of 1,8-diaminonaphthalene (1,8-DAN) and guanidines. Although both are bidentate ligands, 1,8-DAN is dianionic, whereas guanidines are monoanionic. As both ligands are nitrogen-based, they participate in strong interactions with their target element. The strength of chelation is enhanced by the unique pi-systems that both ligands possess. This work deals with the design of 1,8-DAN-based ligands as dianionic systems for the stabilization of main group (B, C, Ge) metals. The catalytic synthesis of guanidines, a class molecules with strong biological relevance, is presented, which is catalysed by lithium. Chapter 1 presents the background and motivation to investigate 1,8-DAN as a versatile ligand as well as the drive to synthesize guanidines by a catalytic method. Chapter 2 discusses the general design of different 1,8-DAN-based ligands by varying their pendant groups. Both symmetric and asymmetric ligands are presented. The transformation from ligands through perimidinium salts to carbenes will then be reviewed. The reason behind the existence of free carbenes versus enetetraamines for other ligands will be explained. Two interesting reactions of free carbenes will be presented and elaborated. Two different types of chelating carbenes, as well as their reactivity will follow. Finally, a metal complex of one of the free carbenes is discussed. Chapter 3 investigates the possible construction of heavier metal carbene analogues. Reasons for the illusiveness of the 1,8-DAN stabilized silylene are discussed, as well as those for the germylene. A stable borane compound is presented with two different ligand systems. Chapter 4 presents the lithium-catalyzed construction of a wide variety of guanidines from amines and carbodiimides. Reasons for their varying yields and reaction conditions are discussed. The scope of the amine substrates is expanded to heterocyclic amines and amides. Finally, the construction of propiolamidines from terminal alkynes and carbodiimides by the same catalytic route is investigated. Crystal structures which support the proposed mechanism are presented. Chapter 5 summarizes the work presented in this document and presents its final conclusions.
Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting
Creators: name: El-Hakim, Alim
name: Cahyani, Inswasti
name: Arief, Muhammad Zulfikar
name: Akbariani, Gilang
name: Ridwanuloh, Asep Muhamad
name: Iryanto, Syam Budi
name: Rahayu, Ratih
name: Mardaeni, Daeng Deni
name: Budhyanto, Vincentius
name: Yusnita
name: Sari, Wening
name: Hidayati, Anggi Pn
name: Razari, Intan
name: Nihayah, Silviatun
name: Prayuni, Kinasih
name: Utomo, Chandra
name: Ningrum, Ratih Asmana
name: Susanti, Susanti
name: Utomo, Ahmad
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Stunting is the result of chronic malnutrition due to the lack of micronutrient-based methyl donors required for epigenetic programming during the first 1000 days of life. Methylation studies using bisulfite conversion from blood DNA are invasive and may not be practical for large-scale epidemiological investigation or nutrition intervention programs. Buccal epithelial methylation may reflect early germline methylation. Therefore, buccal cells can serve as convenient sample sources to collect biomarkers associated with the risk of stunting. This study aims to describe the feasibility of nanopore adaptive sampling in detecting DNA methylation from children’s buccal DNA. We used adaptive sampling of Oxford Nanopore Technology on barcoded samples to describe differential methylation associated with malnutrition. Overall, the level of 5-methylcytosine (5mC) was lower in stunted children than in normal children. We also found differentially methylated regions at the MIR6724 and RNA45SN1 gene loci on chromosome 21, which was higher in stunted children than in normal children. We described and detected differential DNA methylation in the locus previously not known to be associated with stunting. Interestingly, this locus on chromosome 21 has been implicated in the stunted phenotype of Down syndrome.
Hilaria Gössmann: Schreiben als Befreiung. Autobiographische Romane und Erzählungen von Autorinnen der Proletarischen Literaturbewegung Japans
Creators: name: Gebhardt, Lisette
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 66 (1998): ASIEN (Januar)
ПОСЛЕРОДОВЫЕ КРОВОТЕЧЕНИЯ И МАРКЁРЫ ДИСФУНКЦИИ ЭНДОТЕЛИЯ В ЕЁ ПРОГНОЗЕ
Creators: name: Собирова, Ш. К.
name: Каримова, Н. Н.
name: Рустамова, М.У.
Publisher: name: Zenodo
Year: 2024

description: На 1-м этапе обследована 112 беременных в 1-2 триместре, имеющих в анамнезе послеродовое гипотоническое кровотечение, в возрасте от 18 до 45 лет, составивших 1-ю группу. II группу – группу контроля, составили 30 пациенток.. После обследования и выделения группы риска по возникновению послеродового гипотонического кровотечения назначается фармакотерапия по разработанному алгоритму в группе 1А, в состав которой вошли 52 пациенток. Группу 1Б составят 60 пациенток с традиционным методом ведения.   В 1 А группе проведена профилактика развития кровотечения с L-аргинином (Тивортин) – 3 г/сут. в течение 3 недель с 18 недели гестации, в 24 недель и 30 недель, таким образом, проводятся три курса по 3 недели с перерывом на 3 недели. Эффективность фармакотерапии оценена на основании обследования метаболитов оксида азота в крови и проведенные клинико-лабораторные обследования у беременных после окончания лечения.
Phytocompounds as versatile drug-leads targeting mProtease in the SARS-CoV-2 virus: insights from a molecular dynamics study
Creators: name: Dwivedi, Manish
name: Devi, Sreevidya S.
name: Singh, Sukriti
name: Trivedi, Mala
name: Hussain, Nadia
name: Yadav, Shalini
name: Dubey, Kshatresh Dutta
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: SARS-CoV-2 is one of the deadly outbreaks in the present era and still showing its presence around the globe. Researchers have produced various vaccines that offer protection against infection, but we have not yet found a cure for COVID-19. Currently, efforts are focused on identifying effective therapeutic approaches to treat this infectious disease. In the present work, we investigated the main protease (Mpro) protein, a crucial component in SARS-CoV-2 viral particle formation, as a drug target and proposed phytocompounds with therapeutic potential against SARS-CoV-2. Initially, several plant-based resources were exploited to screen around one thousand phytocompounds and further their physiochemical characterization and assessment of drug likeliness were performed using SwissADME. Eventually, we screened 95 compounds based on docking analysis using AutoDock Vina. Five compounds were selected having the highest affinity for Mpro for the analysis of ligand-receptor interaction using molecular dynamic (MD) simulation. Docking and MD simulation studies elucidated the promising stable interaction of selected 5 ligands with Mpro. During MD simulation of 100 ns, Abacopterin F showed the lowest binding energy (–37.13 kcal/mol) with the highest affinity towards Mpro and this compound may be proposed as a lead molecule for further investigation. This interaction may result in modulation of the Mpro activity, consequently leading to hindrance in viral particle formation. However, in-vitro and in-vivo experimental validation would be needed to process the selected phytomolecules as a therapeutic lead against SARS-CoV-2.
Ng Chee Yuen; Nick J. Freeman; Frank H. Huynh (eds.): State-Owned Enterprise Reform in Vietnam. Lessons from Asia; Suiwah Leung (ed.): Vietnam Assessment. Creating a Sound Investment Climate
Creators: name: Kohl, Arno
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 66 (1998): ASIEN (Januar)
Mechanisms of morphogen trafficking: Intraneuronal transport of Shh
Creators: name: Beug, Shawn Terrence
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: The Sonic hedgehog (Shh) morphogen plays an important role in shaping central nervous system (CNS) development. While the function of Shh signalling in many tissues is well understood, the intracellular regulation of Shh trafficking during these processes is relatively unknown. To examine the mechanisms of Shh trafficking in neurons, I generated cDNA constructs coding for Shh isoforms, transfected these into differentiated PC6 cells and primary hippocampal neurons, and monitored protein distribution by fluorescence microscopy and biochemistry. Shh is distributed along axons, dendrites and at the neurite terminals in neurons and is associated intra- and extracellularly with lipid raft markers. Intracellularly, wild type Shh associates with synaptic-like microvesicles and dense core granules (DCGs), and is transported with both fast and slow kinetics. Inhibiting Shh posttranslational modification, including cleavage and lipidation, resulted in the accumulation of Shh morphants with DCGs and lack of cell surface accumulation. Consistent with the enrichment of Shh morphants in DCGs, secretion of Shh could be inducted under depolarizing conditions. Taken together, these observations suggest that long-range Shh transport and signalling in neurons involves trafficking to the regulated secretory pathway and cell surface accumulation of Shh on axons, and suggests a link between neuronal activity and Shh secretion. The second aim involved a GST-pull down affininity purification method to identify potential Shh interacting proteins that could mediate Shh intraneuronal transport. Recombinant Shh-N or Shh-C fused to GST were used as bait and incubated with solubilised membrane fractions from the perinatal rat brain. Interacting proteins were resolved by SDS-PAGE, and individual bands were excised and identified by mass spectrometry. From this screen, 22 proteins were identified to be potential Shh interacting factors. Several candidates specific for Shh-N or Shh-C were identified, and I selected three candidates, Sortilin (Sort1), Glypican 5 (Gpc5) and Low density lipoprotein receptor-related protein 1 (Lrp1), for validation by coimmunoprecipitation. These candidates demonstrate potential to be direct Shh interacting partners that are involved in Shh trafficking, extracellular transport and reception within CSN development. Overall, these results indicate that Shh transport and release is tightly regulated and may be differentially secreted from the cell body or neurite, and rely on context- and tissue-specific protein:protein interactions for appropriate vesicular targeting, intraneuronal trafficking, extracellular transport and reception.
Simone Prodolliet: Händlerinnen, Goldgräber und Staatsbeamte. Sozialgeschichte einer Kleinstadt im Hochland Südwestsumatras
Creators: name: Buchholt, Helmut
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 66 (1998): ASIEN (Januar)
On the association of Hydroxychloroquine and Azithromycin in treating Covid-19 in Italy
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2020
Subjects: Drugs
Covid-19
Hydroxychloroquine
Azithromycin

description: A survey of news and literature about the association of two drugs, hydroxychloroquine and azithromycin, in treating Covid-19 is proposed. In particular, news are focussing on Italy, with the aim of understanding how large is the use of this association of drugs in the country. The recommendations of AIFA are also reported.
description: In this version, there are some typos. At the link https://www.zenodo.org/record/3831174#.XsD3Hc_VLIU you can find the last version. Some links have been added too.
Development of an instrument to assess the impact of an enhanced experiential model on pharmacy students' learning opportunities, skills and attitudes: A retrospective comparative-experimentalist study
Creators: name: Kassam, Rosemin
name: Poole, Gary
name: Collins, John B.
Publisher: name: BioMed Central
Year: 2016

description: Background: Pharmacy schools across North America have been charged to ensure their students are adequately skilled in the principles and practices of pharmaceutical care. Despite this mandate, a large percentage of students experience insufficient opportunities to practice the activities, tasks and processes essential to pharmaceutical care. The objective of this retrospective study of pharmacy students was to: (1) as "proof of concept", test the overall educational impact of an enhanced advanced pharmacy practice experiential (APPE) model on student competencies; (2) develop an instrument to measure students' and preceptors' experiences; and (3) assess the psychometric properties of the instrument. Methods: A comparative-experimental design, using student and preceptor surveys, was used to evaluate the impact of the enhanced community-based APPE over the traditional APPE model. The study was grounded in a 5-stage learning model: (1) an enhanced learning climate leads to (2) better utilization of learning opportunities, including (3) more frequent student/patient consultation, then to (4) improved skills acquisition, thence to (5) more favorable attitudes toward pharmaceutical care practice. The intervention included a one-day preceptor workshop, a comprehensive on-site student orientation and extending the experience from two four-week experiences in different pharmacies to one eight-week in one pharmacy. Results: The 35 student and 38 preceptor survey results favored the enhanced model; with students conducting many more patient consultations and reporting greater skills improvement. In addition, the student self-assessment suggested changes in attitudes favoring pharmaceutical care principles. Psychometric testing showed the instrument to be sensitive, valid and reliable in ascertaining differences between the enhanced and traditional arms. Conclusion: The enhanced experiential model positively affects learning opportunities and competency acquisition, as measured by a new instrument showing sound psychometric properties.
Thyroid hormone regulation of the reproductive neuroendocrine axis of the goldfish (Carassius auratus)
Creators: name: Wiens, Susanna Claire
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Neurobiology.

description: This thesis explores thyroid hormone (TH) effects on adult neuroendocrine brain and pituitary in goldfish (Carassius auratus) to address the hypothesis that THs regulate the reproductive neuroendocrine axis through effects on gamma-aminobutyric acid (GABA), a neurotransmitter that stimulates gonadotropin release in fish. The experimental approach was to increase circulating levels of the TH 3,5,3'-triiodothyronine (T3) in goldfish through waterborne exposures, and measure effects on gene expression, enzyme activity and hormone levels in comparison to controls. In sexually regressed males, T3 exposure decreased gene expression of GABA-synthetic and degradative enzymes (glutamic acid decarboxylase and GABA-transaminase, respectively) in telencephalon in a time- and dose-dependent manner but not in hypothalamus. GABA-transaminase activity was not affected by this T3 challenge. In sexually mature males and females, T3 treatment resulted in increased follicle stimulating hormone beta subunit expression in pituitary in females only, and had no effect on luteinizing hormone (LH) beta subunit expression or circulating LH levels in eider sex. Further experiments with GABA agonists indicated that T3 exposure had no effect on GABA-mediated LH release. TH receptor expression was affected in a tissue-specific manner by T3 exposure, appearing to be autoregulated in pituitary, but unaffected in neuroendocrine brain regions. TH deiodinase expression in brain and pituitary and thyroid stimulating hormone beta subunit expression in pituitary was affected in a manner reflective of negative feedback by T3 to reduce T3 levels in tissues and in circulation to a set-point. Gene expression profiling with cDNA microarrays indicated a large-scale decrease in gene expression in adult male goldfish telencephalon in response to T3. This included genes encoding proteins with functions central to general metabolic activity including mRNA splicing and proteasomal protein turnover, as well as neuroendocrine signalling relevant to reproduction and neurogenesis. In conclusion, THs have the potential to regulate the reproductive neuroendocrine axis through minor effects on GABA function in neuroendocrine brain and sex-dependent effects on glycoprotein hormone subunit gene expression, except for LH beta, in pituitary. Moreover, gene expression in adult teleost brain is responsive to TH, which is critical to understanding the potential for TH regulation of the reproductive neuroendocrine axis in teleosts.