cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Do Ir ao Vir: uma viagem por experiências cientifico-históricas nas ruinas da Villa Romana de Milreu
Creators: name: Reis, Emanuel
name: Colaço, Ana
name: Dias, Filipe
name: Vargues, Filipa
name: Martins, Susana Calado
name: Santos, Marco Antório
name: Francisco, Maria Luísa
name: Garcia, Cristina
name: Ellmer, Janine
name: Maria, Hernani
name: Brigas, Amadeu
name: Pires, Marilia
name: Barreto, Vitor
name: Veiga-Pires, Cristina
Publisher: name: Zenodo
Year: 2019
Subjects: DiVaM
Romano
Milreu
CCVAlg

description: A Villa de Milreu é um exemplo do modelo de ocupação romana da região da Iberia, centrada na exploração dos recursos agrícolas, marinhos e na produção de bens alimentares, que eram exportados por via marítima para os portos do Império.
 O Centro Ciência Viva do Algarve traz “experiências” às ruínas de Milreu pelo quinto ano consecutivo, momento em que pela primeira vez promovemos atividades noturnas.
 Com as atividades deste ano, propomo-nos proporcionar aos participantes “viagens“ tetradimensionais: no espaço, no tempo, na história e no conhecimento. Pretendemos pois que as Ruínas Romanas de Milreu funcionem como a matriz para todas estas “viagens”, e que se assumam como escolas informais e oficinas de promoção de conhecimento e de desenvolvimento de competências em todos os indivíduos envolvidos (público e participantes). No contexto da exploração das atividades de cariz prático “mãos na massa” que iremos implementar, serão abordados por isso tópicos de arquitetura, química, física, engenharia, cálculo e astronomia, entre outros. Assim, partindo-se da apresentação e debate dos saberes existentes à época romana, procurará proporcionar-se a compreensão e evidenciar a contribuição desses saberes à luz dos conceitos científicos contemporâneos.
 Esta iniciativa é dinamizada no âmbito do programa DiVaM 2019.
description: Financiado pela Direcção Geral de Cultura do Algarve ao abrigo do Programa DiVaM
Handling Data Heterogeneity with Generative Replay in Collaborative Learning for Medical Imaging
Creators: name: Qu, Liangqiong
name: Balachandar, Niranjan
name: Zhang, Miao
name: Rubin, Daniel
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Collaborative learning, which enables collaborative and decentralized training of deep neural networks at multiple institutions in a privacy-preserving manner, is rapidly emerging as a valuable technique in healthcare applications. However, its distributed nature often leads to significant heterogeneity in data distributions across institutions. In this paper, we present a novel generative replay strategy to address the challenge of data heterogeneity in collaborative learning methods. Different from traditional methods that directly aggregating the model parameters, we leverage generative adversarial learning to aggregate the knowledge from all the local institutions. Specifically, instead of directly training a model for task performance, we develop a novel dual model architecture: a primary model learns the desired task, and an auxiliary "generative replay model" allows aggregating knowledge from the heterogenous clients. The auxiliary model is then broadcasted to the central sever, to regulate the training of primary model with an unbiased target distribution. Experimental results demonstrate the capability of the proposed method in handling heterogeneous data across institutions. On highly heterogeneous data partitions, our model achieves ~4.88% improvement in the prediction accuracy on a diabetic retinopathy classification dataset, and ~49.8% reduction of mean absolution value on a Bone Age prediction dataset, respectively, compared to the state-of-the art collaborative learning methods.
description: Published as a journal paper at Medical Image Analysis 2022
title: مكتبات العائلات في الإمارات العربيّة المتحدة: مكتبة العلامة عبدالله بن محمد السّركال أنموذجًا/ ناصر بن أحمد بن عيسى السّركال.
Creators: name: السّركال، ناصر بن أحمد بن عيسى
Publisher: name: الأرشيف والمكتبة الوطنية
Year: 2022
Subjects: المكتبات- الإمارت العربية المتحدة- تاريخ

تنوعت مكتبة العلّامة عبدالله بن محمد السركال بين مخطوط ومطبوع، ولندرة المطبوعات في زمنه وصعوبة تحصيلها، نسخ الكثير من الكتب في فنون مختلفة؛ كعلوم القرآن، والحديث والفقه، والسّلوك، واللّغة، والادب، والكيمياء، والفلك، والطْب، وغيرها؛ لذلك كان أكثر مكتبته من المخطوطات. سوف يعرج المقال أولًا على التّعريف بصاحب المكتبة، ثم ينتقل للتفصيل في محتويات المكتبة من مخطوطات ومطبوعات.
Building a Secure and Productive TRE: How I Learned to Stop Worrying and Proxy PyPI
Creators: name: Madge, Jim
name: Craddock, Matt
name: Robinson, James
name: Sarmiento Perez, David
name: O'Reilly, Martin
name: Whitaker, Kirstie Jane
Publisher: name: Zenodo
Year: 2025

description: How can we achieve the right balance between security and productivity in research with sensitive data?

The world is awash with data that can be used to provide insights that benefit society. However, much of this data is effectively unavailable for use by researchers due to privacy concerns.

Unlocking access to this data requires building trust with the custodians who safeguard the data and with society as a whole. Traditionally, this trust has been secured by a "security maximalist" approach, either by design, or through excessive caution.

Here, we share the lessons of 6 years of working with over 50 data providers to support access to sensitive data for research under a flexible framework of information governance and technical controls.We've built an open source information governance framework and reproducibly-deployable, cloud-based Trusted Research Environment (TRE).

In this talk we discuss:

Making governance and security controls explainable to data risk holders

Using a tiered risk model to help achieve shared consensus

Supporting researcher effectiveness

Where security and usability _don't_ end up being a trade-off

The things you don't need in a locked-down environment

The value of sharing governance models and TRE design choices openly

The power of collaborating as a community to address shared challenges

Drawing on our experience, we will set out what a good balance between competing concerns looks like, what we do differently to other TREs, and how you can get involved with both our work and the wider TRE community.
The $q$-analog of the Markoff injectivity conjecture over the language of a balanced sequence
Creators: name: Labbé, Sébastien
name: Lapointe, Mélodie
Publisher: name: arXiv
Year: 2021
Subjects: subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11J06 (Primary) 68R15, 05A30 (Secondary)

description: The Markoff injectivity conjecture states that $w\mapstoμ(w)_{12}$ is injective on the set of Christoffel words where $μ:\{\mathtt{0},\mathtt{1}\}^*\to\mathrm{SL}_2(\mathbb{Z})$ is a certain homomorphism and $M_{12}$ is the entry above the diagonal of a $2\times2$ matrix $M$. Recently, Leclere and Morier-Genoud (2021) proposed a $q$-analog $μ_q$ of $μ$ such that $μ_{q}(w)_{12}|_{q=1}=μ(w)_{12}$ is the Markoff number associated to the Christoffel word $w$ when evaluated at $q=1$. We show that there exists an order $
description: v1: 17 pages, 5 figures, 1 table; v2: 18 pages, restated results in terms of nonnegativity of coefficients of polynomials; v3: 20 pages, improvements made after reviews
Quantifying agent impacts on contact sequences in social interactions
Creators: name: Dekker, Mark M.
name: Blanken, Tessa F.
name: Dablander, Fabian
name: Ou, Jiamin
name: Borsboom, Denny
name: Panja, Debabrata
Publisher: name: arXiv
Year: 2021
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Human social behavior plays a crucial role in how pathogens like SARS-CoV-2 or fake news spread in a population. Social interactions determine the contact network among individuals, while spreading, requiring individual-to-individual transmission, takes place on top of the network. Studying the topological aspects of a contact network, therefore, not only has the potential of leading to valuable insights into how the behavior of individuals impacts spreading phenomena, but it may also open up possibilities for devising effective behavioral interventions. Because of the temporal nature of interactions - since the topology of the network, containing who is in contact with whom, when, for how long, and in which precise sequence, varies (rapidly) in time - analyzing them requires developing network methods and metrics that respect temporal variability, in contrast to those developed for static (i.e., time-invariant) networks. Here, by means of event mapping, we propose a method to quantify how quickly agents mingle by transforming temporal network data of agent contacts. We define a novel measure called 'contact sequence centrality', which quantifies the impact of an individual on the contact sequences, reflecting the individual's behavioral potential for spreading. Comparing contact sequence centrality across agents allows for ranking the impact of agents and identifying potential 'behavioral super-spreaders'. The method is applied to social interaction data collected at an art fair in Amsterdam. We relate the measure to the existing network metrics, both temporal and static, and find that (mostly at longer time scales) traditional metrics lose their resemblance to contact sequence centrality. Our work highlights the importance of accounting for the sequential nature of contacts when analyzing social interactions.
description: 14 pages, 4 fugures, separate supplementary information in pdf
Lifshitz transition in dirty nematic superconductor
Creators: name: Akzyanov, R. S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the effects of the Lifshitz transition from closed to open Fermi surface in dirty topological insulators with the nematic superconductivity near the critical temperature. We solve linearized Gor'kov equations and find that the nematic superconductor with an open Fermi surface has a lower critical temperature and more susceptible to the disorder than the superconductor with the closed Fermi surface. We propose that correspondence between the critical temperature and stability against the disorder is the general feature of the superconductivity. We investigate the effects of the Lifshitz transition on the competition between superconducting phases in a topological insulator. Open Fermi surface is beneficial for the nematic order parameter $Δ_4$ in competition with orbital-triplet $Δ_2$ and disfavors nematic state over the s-wave order parameter. We study Meissner currents in both clean and dirty limits. We found that transition from closed to open Fermi surface increases anisotropy of Meissner currents. Finite disorder suppresses superconducting density stronger than critical temperature. We compare our results with the existing experimental data.
description: 10 pages, 7 figures
Quantum transport and localization in 1d and 2d tight-binding lattices
Creators: name: Karamlou, Amir H.
name: Braumüller, Jochen
name: Yanay, Yariv
name: Di Paolo, Agustin
name: Harrington, Patrick
name: Kannan, Bharath
name: Kim, David
name: Kjaergaard, Morten
name: Melville, Alexander
name: Muschinske, Sarah
name: Niedzielski, Bethany
name: Vepsäläinen, Antti
name: Winik, Roni
name: Yoder, Jonilyn L.
name: Schwartz, Mollie
name: Tahan, Charles
name: Orlando, Terry P.
name: Gustavsson, Simon
name: Oliver, William D.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Particle transport and localization phenomena in condensed-matter systems can be modeled using a tight-binding lattice Hamiltonian. The ideal experimental emulation of such a model utilizes simultaneous, high-fidelity control and readout of each lattice site in a highly coherent quantum system. Here, we experimentally study quantum transport in one-dimensional and two-dimensional tight-binding lattices, emulated by a fully controllable $3 \times 3$ array of superconducting qubits. We probe the propagation of entanglement throughout the lattice and extract the degree of localization in the Anderson and Wannier-Stark regimes in the presence of site-tunable disorder strengths and gradients. Our results are in quantitative agreement with numerical simulations and match theoretical predictions based on the tight-binding model. The demonstrated level of experimental control and accuracy in extracting the system observables of interest will enable the exploration of larger, interacting lattices where numerical simulations become intractable.
Accounting for spatial confounding in epidemiological studies with individual-level exposures: An exposure-penalized spline approach
Creators: name: Bobb, Jennifer F.
name: Cruz, Maricela F.
name: Mooney, Stephen J.
name: Drewnowski, Adam
name: Arterburn, David
name: Cook, Andrea J.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In the presence of unmeasured spatial confounding, spatial models may actually increase (rather than decrease) bias, leading to uncertainty as to how they should be applied in practice. We evaluated spatial modeling approaches through simulation and application to a big data electronic health record study. Whereas the risk of bias was high for purely spatial exposures (e.g., built environment), we found very limited potential for increased bias for individual-level exposures that cluster spatially (e.g., smoking status). We also proposed a novel exposure-penalized spline approach that selects the degree of spatial smoothing to explain spatial variability in the exposure. This approach appeared promising for efficiently reducing spatial confounding bias.
description: 30 pages, 5 figures, supplemental material
Additional file 4 of The clinical significance of integrin subunit alpha V in cancers: from small cell lung carcinoma to pan-cancer
Creators: name: Tang, Yu-Lu
name: Li, Guo-Sheng
name: Li, Dong-Ming
name: Tang, Deng
name: Huang, Jie-Zhuang
name: Feng, Hao
name: He, Rong-Quan
name: Huang, Zhi-Guang
name: Dang, Yi-Wu
name: Kong, Jin-Liang
name: Gan, Ting-Qing
name: Zhou, Hua-Fu
name: Zeng, Jing-Jing
name: Chen, Gang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 4. Information of datasets included in the study.
Real-space effects of a quench in the Su-Schrieffer-Heeger model and elusive dynamical appearance of the topological edge states
Creators: name: Rossi, Lorenzo
name: Rossi, Fausto
name: Dolcini, Fabrizio
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The topological phase of the Su-Schrieffer-Heeger (SSH) model is known to exhibit two edge states that are topologically protected by the chiral symmetry. We demonstrate that, for any parameter quench performed on the half-filled SSH chain, the occupancy of each lattice site remains locked to $1/2$ at any time, due to the additional time-reversal and charge conjugation symmetries. In particular, for a quench from the trivial to the topological phase, no signature of the topological edge states appears in real-space occupancies, independently of the quench protocol, the temperature of the pre-quench thermal state or the presence of chiral disorder. However, a suitably designed local quench from/to a SSH ring threaded by a magnetic flux can break these additional symmetries while preserving the chiral one. Then, real-space effects of the quench do appear and exhibit different dynamical features in the topological and in the trivial phases. Moreover, when the particle filling is different from a half and the pre-quench state is not insulating, the dynamical appearance of the topological edge states is visible already in a chain, it survives time averaging and can be observed also in the presence of chiral-breaking disorder and for instantaneous quenches.
description: 17 pages, 7 figures
Frequency to power conversion by an electron turnstile
Creators: name: Marín-Suárez, Marco
name: Peltonen, Joonas T.
name: Golubev, Dmitry S.
name: Pekola, Jukka P.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Direct frequency to power conversion (FPC), to be presented here, links both quantities through a known energy, like single-electron transport relates an operation frequency $f$ to the emitted current $I$ through the electron charge $e$ as $I=ef$. FPC is a natural candidate for a power standard resorting to the most basic definition of the watt -- energy, which is traceable to Planck's constant $h$, emitted per unit of time. This time is in turn traceable to the unperturbed ground state hyperfine transition frequency of the caesium 133 atom $Δν_\mathrm{Cs}$; hence, FPC comprises a simple and elegant way to realize the watt. In this spirit, single-photon emission and detection at known rates have been proposed and experimented as radiometric standard. However, nowadays power standards are only traceable to electrical units, i.e., volt and ohm. In this letter, we demonstrate the feasibility of an alternative proposal based on solid-state direct FPC using a SINIS (S = superconductor, N = normal metal, I = insulator) single-electron transistor (SET) accurately injecting $N$ (integer) quasiparticles (qps) per cycle to both leads with discrete energies close to their superconducting gap $Δ$, even at zero drain-source voltage. Furthermore, the bias voltage plays an important role in the distribution of the power among the two leads, allowing for an almost equal injection $NΔf$ to the two. We estimate that under appropriate conditions errors can be well below $1\%$.
description: Includes supplementary information
Relativity 4-ever?
Creators: name: Chashchina, Olga
name: Silagadze, Zurab
Publisher: name: arXiv
Year: 2021
Subjects: subject: Popular Physics (physics.pop-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This essay is about superluminal motion. It is generally believed that special relativity prohibits movements faster than the speed of light. It is explained which motion is actually forbidden by special relativity and why. Tachyons are briefly discussed and it is explained that, due to internal instability, tachyon fields cannot be used to transmit information faster than the speed of light. However, as John Stuart Bell remarked, "what is proved by the impossibility proofs is lack of imagination". Inspired by the Frenkel-Kontorova model of crystal dislocations, we demonstrate the way to overcome the light speed barrier by introducing elvisebrions. Elvisebrions are defined as objects that can exist in the case when some hidden sectors, very weakly interacting with the visible sector, are either not Lorentz invariant, or Lorentz invariant but with different limiting velocities. In this case, elvisebrions can move in a superluminal manner without violating our existing physical models.
description: 18 pages, 12 figures, published version
Particle-like topologies in light
Creators: name: Sugic, Danica
name: Droop, Ramon
name: Otte, Eileen
name: Ehrmanntraut, Daniel
name: Nori, Franco
name: Ruostekoski, Janne
name: Denz, Cornelia
name: Dennis, Mark R.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Three-dimensional (3D) topological states resemble truly localised, particle-like objects in physical space. Among the richest such structures are 3D skyrmions and hopfions that realise integer topological numbers in their configuration via homotopic mappings from real space to the hypersphere (sphere in 4D space) or the 2D sphere. They have received tremendous attention as exotic textures in particle physics, cosmology, superfluids, and many other systems. Here we experimentally create and measure a topological 3D skyrmionic hopfion in fully structured light. By simultaneously tailoring the polarization and phase profile, our beam establishes the skyrmionic mapping by realising every possible optical state in the propagation volume. The resulting light field's Stokes parameters and phase are synthesised into a Hopf fibration texture. We perform volumetric full-field reconstruction of the $Π_3$ mapping, measuring a quantised topological charge, or Skyrme number, of 0.945. Such topological state control opens new avenues for 3D optical data encoding and metrology. The Hopf characterisation of the optical hypersphere endows a new perspective to topological optics, offering experimentally accessible photonic analogues to the gamut of particle-like 3D topological textures, from condensed matter to high-energy physics.
description: Main text: 9 pages, 4 figures; Methods: 6 pages; Supplementary Information: 28 pages, 10 figures
How to Certify Machine Learning Based Safety-critical Systems? A Systematic Literature Review
Creators: name: Tambon, Florian
name: Laberge, Gabriel
name: An, Le
name: Nikanjam, Amin
name: Mindom, Paulina Stevia Nouwou
name: Pequignot, Yann
name: Khomh, Foutse
name: Antoniol, Giulio
name: Merlo, Ettore
name: Laviolette, François
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Context: Machine Learning (ML) has been at the heart of many innovations over the past years. However, including it in so-called 'safety-critical' systems such as automotive or aeronautic has proven to be very challenging, since the shift in paradigm that ML brings completely changes traditional certification approaches. Objective: This paper aims to elucidate challenges related to the certification of ML-based safety-critical systems, as well as the solutions that are proposed in the literature to tackle them, answering the question 'How to Certify Machine Learning Based Safety-critical Systems?'. Method: We conduct a Systematic Literature Review (SLR) of research papers published between 2015 to 2020, covering topics related to the certification of ML systems. In total, we identified 217 papers covering topics considered to be the main pillars of ML certification: Robustness, Uncertainty, Explainability, Verification, Safe Reinforcement Learning, and Direct Certification. We analyzed the main trends and problems of each sub-field and provided summaries of the papers extracted. Results: The SLR results highlighted the enthusiasm of the community for this subject, as well as the lack of diversity in terms of datasets and type of models. It also emphasized the need to further develop connections between academia and industries to deepen the domain study. Finally, it also illustrated the necessity to build connections between the above mention main pillars that are for now mainly studied separately. Conclusion: We highlighted current efforts deployed to enable the certification of ML based software systems, and discuss some future research directions.
description: 60 pages (92 pages with references and complements), submitted to a journal (Automated Software Engineering). Changes: Emphasizing difference traditional software engineering / ML approach. Adding Related Works, Threats to Validity and Complementary Materials. Adding a table listing papers reference for each section/subsections
Signature Gröbner bases, bases of syzygies and cofactor reconstruction in the free algebra
Creators: name: Hofstadler, Clemens
name: Verron, Thibaut
Publisher: name: arXiv
Year: 2021
Subjects: subject: Symbolic Computation (cs.SC)
subject: Rings and Algebras (math.RA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Signature-based algorithms have become a standard approach for computing Gröbner bases in commutative polynomial rings. However, so far, it was not clear how to extend this concept to the setting of noncommutative polynomials in the free algebra. In this paper, we present a signature-based algorithm for computing Gröbner bases in precisely this setting. The algorithm is an adaptation of Buchberger's algorithm including signatures. We prove that our algorithm correctly enumerates a signature Gröbner basis as well as a Gröbner basis of the module generated by the leading terms of the generators' syzygies, and that it terminates whenever the ideal admits a finite signature Gröbner basis. Additionally, we adapt well-known signature-based criteria eliminating redundant reductions, such as the syzygy criterion, the F5 criterion and the singular criterion, to the case of noncommutative polynomials. We also generalize reconstruction methods from the commutative setting that allow to recover, from partial information about signatures, the coordinates of elements of a Gröbner basis in terms of the input polynomials, as well as a basis of the syzygy module of the generators. We have written a toy implementation of all the algorithms in the Mathematica package OperatorGB and we compare our signature-based algorithm to the classical Buchberger algorithm for noncommutative polynomials.
description: 31 pages, 2 pages appendix, 1 figure
Novel Strategy to Enhance Human Mesenchymal Stromal Cell Immunosuppression: Harnessing Interferon-Gamma Presentation in Metal–Organic Frameworks Embedded on Heparin/Collagen Multilayers
Creators: name: Haseli, Mahsa
name: Pinzon-Herrera, Luis
name: Hao, Xiaolei
name: Wickramasinghe, S. Ranil
name: Almodovar, Jorge
Publisher: name: ACS
Year: 2023

description: The immunomodulatory potential of human mesenchymal stromal cells (hMSCs) can be boosted when exposed to interferon-gamma (IFN-γ). While pretreating hMSCs with IFN-γ is a common practice to enhance their immunomodulatory effects, the challenge lies in maintaining a continuous IFN-γ presence within cellular environments. Therefore, in this research, we investigate the sustainable presence of IFN-γ in the cell culture medium by immobilizing it in water-stable metal–organic frameworks (MOFs) [PCN-333(Fe)]. The immobilized IFN-γ in MOFs was coated on top of multilayers composed of combinations of heparin (HEP) and collagen (COL) that were used as a bioactive surface. Multilayers were created by using a layer-by-layer assembly technique, with the final layer alternating between collagen (COL) and heparin (HEP). We evaluated the viability, differentiation, and immunomodulatory activity of hMSCs cultured on (HEP/COL) coated with immobilized IFN-γ in MOFs after 3 and 6 days of culture. Cell viability, compared to tissue culture plastic, was not affected by immobilized IFN-γ in MOFs when they were coated on (HEP/COL) multilayers. We also verified that the osteogenic and adipogenic differentiation of the hMSCs remained unchanged. The immunomodulatory activity of hMSCs was evaluated by examining the expression of indoleamine 2,3-dioxygenase (IDO) and 11 essential immunomodulatory markers. After 6 days of culture, IDO expression and the expression of 11 immunomodulatory markers were higher in (HEP/COL) coated with immobilized IFN-γ in MOFs. Overall, (HEP/COL) multilayers coated with immobilized IFN-γ in MOFs provide a sustained presentation of cytokines to potentiate the hMSC immunomodulatory activity.
Delivery of Immobilized IFN-γ With PCN-333 and Its Effect on Human Mesenchymal Stem Cells
Creators: name: Phipps, Josh
name: Haseli, Mahsa
name: Pinzon-Herrera, Luis
name: Wilson, Ben
name: Corbitt, Joshua
name: Servoss, Shannon
name: Almodovar, Jorge
Publisher: name: ACS
Year: 2023

description: Interferon-gamma (IFN-γ) plays a vital role in modulating the immunosuppressive properties of human mesenchymal stem/stromal cells (hMSCs) used in cell therapies. However, IFN-γ suffers from low bioavailability and degrades in media, creating a challenge when using IFN-γ during the manufacturing of hMSCs. Metal–organic frameworks (MOFs), with their porous interiors, biocompatibility, high loading capacity, and ability to be functionalized for targeting, have become an increasingly suitable platform for protein delivery. In this work, we synthesize the MOF PCN-333(Fe) and show that it can be utilized to immobilize and deliver IFN-γ to the local extracellular environment of hMSCs. In doing so, the cells proliferate and differentiate appropriately with no observed side effects. We demonstrate that PCN-333(Fe) MOFs containing IFN-γ are not cytotoxic to hMSCs, can promote the expression of proteins that play a role in immune response, and are capable of inducing indoleamine 2,3-dioxygenase (IDO) production similar to that of soluble IFN-γ at lower concentrations. Overall, using MOFs to deliver IFN-γ may be leveraged in the future in the manufacturing of therapeutically relevant hMSCs.
Chemical engineering and the circular water economy: Simulations for sustainable water management in environmental systems
Creators: name: Obiuto, Nwankwo Constance
name: Olu-Lawal, Kehinde Andrew
name: Ani, Emmanuel Chigozie
name: Ugwuanyi, Ejike David
name: Ninduwezuor-Ehiobu, Nwakamma
Publisher: name: WJARR
Year: 2024

description: In the face of escalating water scarcity and environmental degradation, the imperative for sustainable water management has never been more urgent. Chemical engineering emerges as a pivotal discipline in the pursuit of solutions to these pressing challenges. This review explores the role of chemical engineering in advancing the circular water economy paradigm through simulations aimed at fostering sustainable water management within environmental systems. The circular water economy concept advocates for the efficient utilization, recycling, and reclamation of water resources to minimize waste and maximize resource efficiency. Chemical engineering techniques play a fundamental role in realizing this vision through the design and optimization of water treatment processes, resource recovery systems, and advanced simulation methodologies. This review delves into the application of computational simulations within the realm of chemical engineering to model and analyze various aspects of the water cycle. Such simulations enable the assessment of complex environmental systems, aiding in the identification of optimal strategies for water resource allocation, pollution control, and ecosystem preservation. Key areas of focus include the simulation of wastewater treatment processes, such as biological, physical, and chemical treatment methods, to enhance pollutant removal efficiency and promote water reuse. Furthermore, advanced modeling techniques facilitate the evaluation of innovative technologies like membrane filtration, adsorption, and electrochemical processes for the purification and desalination of water resources. Moreover, chemical engineering simulations enable the assessment of integrated water management strategies, encompassing aspects of urban water systems, industrial processes, and agricultural practices. By considering the interconnectedness of various sectors, holistic approaches to water resource management can be formulated, promoting resilience and sustainability in the face of changing environmental conditions. The integration of chemical engineering simulations into the framework of the circular water economy offers a promising avenue for advancing sustainable water management practices. Through comprehensive modeling and analysis, informed decision-making can pave the way towards a more resilient and equitable water future, ensuring the long-term viability of our environmental systems.
Reviewing the potential of anaerobic membrane bioreactors in wastewater treatment
Creators: name: Ugwuanyi, Ejike David
name: Nwokediegwu, Zamathula Queen Sikhakhane
name: Dada, Michael Ayorinde
name: Majemite, Michael Tega
name: Obaigbena, Alexander
Publisher: name: IJSRA
Year: 2024

description: Anaerobic membrane bioreactors (AnMBRs) represent an innovative approach to wastewater treatment, combining anaerobic digestion with membrane filtration to achieve efficient organic pollutant removal and resource recovery. This review critically examines the potential of AnMBRs in wastewater treatment, highlighting their principles, advantages, challenges, recent advancements, and future prospects. AnMBRs offer several advantages over traditional aerobic treatment methods, including higher organic loading rates, reduced energy requirements, and biogas production through methane generation. However, challenges such as membrane fouling, reactor complexity, and operational costs have limited their widespread adoption. Recent advancements in membrane materials, fouling mitigation strategies, and process optimization have improved AnMBR performance and feasibility. Novel membrane materials with enhanced fouling resistance and durability have been developed, while innovative cleaning techniques and operational protocols have been implemented to mitigate membrane fouling and prolong membrane lifespan. Process optimization strategies, including reactor design modifications and operational parameter adjustments, have enhanced treatment efficiency and reduced energy consumption in AnMBRs. Future research directions in AnMBR technology focus on optimizing reactor configurations, exploring novel membrane materials and fouling control strategies, and conducting comprehensive techno-economic assessments to evaluate the environmental and economic sustainability of AnMBRs. Integration of AnMBRs with emerging technologies such as membrane distillation, forward osmosis, and bioelectrochemical systems holds promise for further enhancing treatment performance and resource recovery capabilities. Additionally, addressing knowledge gaps in membrane fouling mechanisms, microbial community dynamics, and long-term system stability is crucial for advancing AnMBR technology and facilitating its widespread implementation in wastewater treatment. Overall, AnMBRs offer significant potential for sustainable wastewater treatment, providing opportunities for organic pollutant removal, energy recovery, and resource reuse. By addressing technical challenges, optimizing process parameters, and conducting interdisciplinary research, AnMBRs can contribute to the development of efficient, cost-effective, and environmentally friendly wastewater treatment solutions, ultimately supporting the goal of achieving cleaner water resources and a more sustainable future.
Chemical management in electronics manufacturing: Protecting worker health and the environment
Creators: name: Obiuto, Nwankwo Constance
name: Olu-Lawal, Kehinde Andrew
name: Ani, Emmanuel Chigozie
name: Ugwuanyi, Ejike David
name: Ninduwezuor-Ehiobu, Nwakamma
Publisher: name: WJARR
Year: 2024

description: In the realm of electronics manufacturing, the management of chemicals is paramount to safeguarding both worker health and environmental sustainability. This review delves into the strategies and challenges associated with chemical management within this industry. The utilization of various chemicals in electronics manufacturing processes presents potential hazards to both workers and the environment. From cleaning agents to solvents and fluxes, these substances pose risks ranging from acute toxicity to long-term health effects and environmental contamination. Effective chemical management strategies are therefore indispensable. This review discusses the proactive measures implemented by electronics manufacturers to mitigate these risks. It explores the adoption of alternative, less hazardous chemicals and the implementation of engineering controls to minimize exposure. Additionally, stringent protocols for handling, storage, and disposal are essential components of comprehensive chemical management programs. Furthermore, regulatory frameworks play a pivotal role in shaping chemical management practices within the electronics manufacturing sector. Compliance with local and international regulations such as REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) and RoHS (Restriction of Hazardous Substances) is imperative to ensure the safety of workers and the environment. However, despite these efforts, challenges persist. Balancing the need for innovation and productivity with chemical safety requirements remains a significant challenge for manufacturers. Additionally, global supply chain complexities add another layer of complexity to chemical management efforts. Effective chemical management in electronics manufacturing demands a multi-faceted approach encompassing technological innovation, regulatory compliance, and a commitment to worker health and environmental stewardship. By addressing these challenges collaboratively, the industry can strive towards safer and more sustainable practices.
Designing order-disorder transformation in high-entropy ferritic steels
Creators: name: Singh
name: Prashant
name: Johnson
name: D, Duane
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Order-disorder transformations hold an essential place in chemically complex high-entropy ferritic-steels (HEFSs) due to their critical technological application. The chemical inhomogeneity arising from mixing of multi-principal elements of varying chemistry can drive property altering changes at the atomic scale, in particular short-range order. Using density-functional theory based linear-response theory, we predict the effect of compositional tuning on the order-disorder transformation in ferritic steels -focusing on Cr-Ni-Al-Ti-Fe HEFSs. We show that Ti content in Cr-Ni-Al-Ti-Fe solid solutions can be tuned to modify short-range order that changes the order-disorder path from BCC-B2 (Ti atomic-fraction = 0) to BCC-B2-L21 (Ti atomic-faction $>$ 0) consistent with existing experiments. Our study suggests that tuning degree of SRO through compositional variation can be used as an effective means to optimize phase selection in technologically useful alloys.
description: 23 pages, 6 figures
Measurement-device-independent quantum key distribution with classical Bob and no joint measurement
Creators: name: He, Guang Ping
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Measurement-device-independent quantum key distribution (MDI-QKD) provides a method for secret communication whose security does not rely on trusted measurement devices. In all existing MDI-QKD protocols, the participant Charlie has to perform the Bell state measurement or other joint measurements. Here we propose an MDI-QKD protocol which requires individual measurements only. Meanwhile, all operations of the receiver Bob are classical, without the need for preparing and measuring quantum systems. Thus the implementation of the protocol has a lower technical requirement on Bob and Charlie.
description: 6 pages, 1 figure
Knot probabilities in equilateral random polygons
Creators: name: Xiong, A.
name: Taylor, A. J.
name: Dennis, M. R.
name: Whittington, S. G.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Geometric Topology (math.GT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider the probability of knotting in equilateral random polygons in Euclidean 3-dimensional space, which model, for instance, random polymers. Results from an extensive Monte Carlo dataset of random polygons indicate a universal scaling formula for the knotting probability with the number of edges. This scaling formula involves an exponential function, independent of knot type, with a power law factor that depends on the number of prime components of the knot. The unknot, appearing as a composite knot with zero components, scales with a small negative power law, contrasting with previous studies that indicated a purely exponential scaling. The methodology incorporates several improvements over previous investigations: our random polygon data set is generated using a fast, unbiased algorithm, and knotting is detected using an optimised set of knot invariants based on the Alexander polynomial.
description: 24 pages, 8 figures
Distance-Independent Entanglement Generation in a Quantum Network using Space-Time Multiplexed Greenberger-Horne-Zeilinger (GHZ) Measurements
Creators: name: Patil, Ashlesha
name: Jacobson, Joshua I.
name: van Milligen, Emily
name: Towsley, Don
name: Guha, Saikat
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In a quantum network that successfully creates links, shared Bell states between neighboring repeater nodes, with probability $p$ in each time slot, and performs Bell State Measurements at nodes with success probability $q<1$, the end to end entanglement generation rate drops exponentially with the distance between consumers, despite multi-path routing. If repeaters can perform multi-qubit projective measurements in the GHZ basis that succeed with probability $q$, the rate does not change with distance in a certain $(p,q)$ region, but decays exponentially outside. This region where the distance independent rate occurs is the supercritical region of a new percolation problem. We extend this GHZ protocol to incorporate a time-multiplexing blocklength $k$, the number of time slots over which a repeater can mix-and-match successful links to perform fusion on. As $k$ increases, the supercritical region expands. For a given $(p,q)$, the entanglement rate initially increases with $k$, and once inside the supercritical region for a high enough $k$, it decays as $1/k$ GHZ states per time slot. When memory coherence time exponentially distributed with mean $μ$ is incorporated, it is seen that increasing $k$ does not indefinitely increase the supercritical region; it has a hard $μ$ dependent limit. Finally, we find that incorporating space-division multiplexing, i.e., running the above protocol independently in up to $d$ disconnected network regions, where $d$ is the network's node degree, one can go beyond the 1 GHZ state per time slot rate that the above randomized local link-state protocol cannot surpass. As $(p,q)$ increases, one can approach the ultimate min-cut entanglement generation capacity of $d$ GHZ states per slot.
description: 13 pages, q0 figures, Accepted in IEEE QCE 2021
Additional file 6 of The clinical significance of integrin subunit alpha V in cancers: from small cell lung carcinoma to pan-cancer
Creators: name: Tang, Yu-Lu
name: Li, Guo-Sheng
name: Li, Dong-Ming
name: Tang, Deng
name: Huang, Jie-Zhuang
name: Feng, Hao
name: He, Rong-Quan
name: Huang, Zhi-Guang
name: Dang, Yi-Wu
name: Kong, Jin-Liang
name: Gan, Ting-Qing
name: Zhou, Hua-Fu
name: Zeng, Jing-Jing
name: Chen, Gang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6. There is no significant difference in clinical parameters between high-ITGAV and low-ITGAV expression groups (for disease-free survival).
МАСТЕР РОМАНТИЧЕСКОГО ПЕЙЗАЖА
Creators: name: Преподаватель русского языка и литературы Бухарского университета инноваций Рузиева Дилфуза Норсаидовна
Publisher: name: Zenodo
Year: 2024

description: В статье освещаются основные этапы творчества писателя, начиная с ранних «крымских» рассказов, где автор показывает себя мастером романтического пейзажа, и заканчивая его зрелыми произведениями, где акцент делается на гармонии человека с природой и внутренним миром героев. Особое внимание уделено анализу стилевых приемов и образного мира Паустовского, его восприятия природы как активного участника повествования. Статья исследует эволюцию жанровых предпочтений писателя на примере разнообразных произведений, отмечая его способность к глубокому восприятию и воплощению мира в искусстве слова.
Adaptive Simultaneous Magnetic Actuation and Localization for WCE in a Tubular Environment
Creators: name: Xu, Yangxin
name: Li, Keyu
name: Zhao, Ziqi
name: Meng, Max Q. -H.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Simultaneous Magnetic Actuation and Localization (SMAL) is a promising technology for active wireless capsule endoscopy (WCE). In this paper, an adaptive SMAL system is presented to efficiently propel and precisely locate a capsule in a tubular environment with complex shapes. In order to track the capsule with high localization accuracy and update frequency in a large workspace, we propose a mechanism that can automatically activate a sub-array of sensors with the optimal layout during the capsule movement. The improved multiple objects tracking (IMOT) method is simplified and adapted to our system to estimate the 6-D pose of the capsule in real time. Also, we study the locomotion of a magnetically actuated capsule in a tubular environment, and formulate a method to adaptively adjust the pose of the actuator to improve the propulsion efficiency. Our presented methods are applicable to other permanent magnet-based SMAL systems, and help to improve the actuation efficiency of active WCE. We verify the effectiveness of our proposed system in extensive experiments on phantoms and ex-vivo animal organs. The results demonstrate that our system can achieve convincing performance compared with the state-of-the-art ones in terms of actuation efficiency, workspace size, robustness, localization accuracy and update frequency.
Uncertainty limits on neutron star radius measurements with gravitational waves
Creators: name: Chatziioannou, Katerina
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Upcoming observing campaigns with improved detectors will yield numerous detections of gravitational waves from neutron star binary inspirals. Rare loud signals together with numerous signals of moderate strength promise stringent constraints on the properties of neutron star matter, with a projected radius statistical uncertainty of $50-200$m with ${\cal{O}}(2000)$ sources. Given this precision we revisit all analysis assumptions and identify sources of systematic errors, quantify their impact on radius extraction, and discuss their relative importance and ways to mitigate them.
description: 5 pages, 3 figures, published version