cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
PODOCNEMIS UNIFILIS (Yellow-spotted River Turtle). NEST PREDATION BY ANTS
Creators: name: Wesley, D.
Publisher: name: figshare
Year: 2015
Subjects: subject: Zoology
subject: FOS: Biological sciences

description: PODOCNEMIS UNIFILIS (Yellow-spotted River Turtle). NEST PREDATION BY ANTS
Diet type modifies ingestion rates and trophallactic exchanges in leaf-cutting ants
Creators: name: Wesley, D.
Publisher: name: figshare
Year: 2015
Subjects: subject: Zoology
subject: FOS: Biological sciences

description: Conventional control of leaf-cutting ants is mainly carried out by application of solid insecticide baits. However, alternative approaches could increase the efficiency of control methods. Here, we investigated the hypothesis that liquid and semi-solid baits are more readily ingested by leaf-cutting ants and are therefore more toxic than solid baits. Furthermore, following increased ingestion rates, ants could perform higher frequencies of trophallactic exchanges with their nest mates, thus increasing dispersal rates within the colony. Each of three diets were offered to Acromyrmex subterraneus subterraneus (Forel) and Atta sexdens rubropilosa Forel (both Hymenoptera: Formicidae) for 1 h under laboratory conditions and subsequently crop volumes were quantified. The highest crop volumes for both species were seen when the diet was offered in liquid form, and the lowest crop volumes were observed after offering solid diets. Survival rates of the ants were monitored following addition of the neonicotinoid insecticide imidacloprid (IMI) to the three diets. The ingestion of liquid and semi-solid diets + IMI by A. subterraneus resulted in 17 and 6% survival, respectively, whereas these diets caused 100% mortality of A. sexdens. Ingestion of solid diets with IMI resulted in 51%survival of A. subterraneus and 23%survival of Atta workers. Twenty-three percent of A. subterraneus which had fed on liquid diet carried out trophallactic exchanges, whereas only 10 and 3% of ants carried out trophallaxis when fed on semi-solid or solid diet, respectively. Lower trophallactic frequencies were observed for A. sexdens, with 13 and 3% of ants that had fed on liquid and semisolid diets performing trophallaxis, respectively. The low trophallactic exchange rates following ingestion of solid diets would reduce the dispersal of these compounds throughout the colony. Control strategies using solid baits should be re-examined in the light of these findings, which indicate the importance of optimizing insecticide ingestion.
Maximum-Entropy Prior Uncertainty and Correlation of Statistical Economic Data
Creators: name: Rodrigues, João D. F.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Empirical estimates of source statistical economic data such as trade flows, greenhouse gas emissions, or employment figures are always subject to uncertainty (stemming from measurement errors or confidentiality) but information concerning that uncertainty is often missing. This article uses concepts from Bayesian inference and the maximum entropy principle to estimate the prior probability distribution, uncertainty, and correlations of source data when such information is not explicitly provided. In the absence of additional information, an isolated datum is described by a truncated Gaussian distribution, and if an uncertainty estimate is missing, its prior equals the best guess. When the sum of a set of disaggregate data is constrained to match an aggregate datum, it is possible to determine the prior correlations among disaggregate data. If aggregate uncertainty is missing, all prior correlations are positive. If aggregate uncertainty is available, prior correlations can be either all positive, all negative, or a mix of both. An empirical example is presented, which reports relative uncertainties and correlation priors for the County Business Patterns database. In this example, relative uncertainties range from 1% to 80% and 20% of data pairs exhibit correlations below −0.9 or above 0.9. Supplementary materials for this article are available online.
Improved Time-Resolved Measurements of Inorganic Ions in Particulate Matter by PILS-IC Integrated with a Sample Pre-Concentration System
Creators: name: Perrino, Cinzia
name: Catrambone, Maria
name: Farao, Carmela
name: Salzano, Roberto
name: Esposito, Giulio
name: Giusto, Marco
name: Montagnoli, Mauro
name: Marini, Angelo
name: Brinoni, Mirko
name: Simonetti, Giulia
name: Canepari, Silvia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine
subject: Engineering

description: A particle-into-liquid sampler coupled with ion chromatograph (PILS-IC) for the on-line measurement of inorganic ions has been modified by the insertion of two ion-exchange pre-concentration cartridges that enrich the sample during the period of the IC analysis. The limits of detection of the modified instrument were 10-15 times lower and the time coverage 24 times higher (from 2 to 48 min per hour) than those of the original PILS-IC setup. The instrumental performance in terms of recovery and break-through volume from the cartridges was satisfactory. The modified PILS-IC was operated in comparison with a diffusion denuder line and with a high-resolution time-of-flight aerosol mass spectrometer (HR-TOF-AMS) during a short intensive measurement period organized in the framework of the European Monitoring and Evaluation Programme (EMEP), a co-operative program for monitoring and evaluation of the long-range transmission of the air pollutants in Europe. The instrument showed a quantitative response in agreement with the results of the diffusion lines, and an ability to trace fine concentration variations not so different from the performance of the much more complex HR-TOF-AMS. From the time patterns of the ion concentrations measured by the modified PILS-IC, it was possible to obtain useful information about the variations in the air quality and in the strength of the particulate matter sources.Copyright 2015 American Association for Aerosol Research
Efficient Estimation of Data Combination Models by the Method of Auxiliary-to-Study Tilting (AST)
Creators: name: Graham, Bryan S.
name: Pinto, Cristine Campos De Xavier
name: Egel, Daniel
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: We propose a locally efficient estimator for a class of semiparametric data combination problems. A leading estimand in this class is the average treatment effect on the treated (ATT). Data combination problems are related to, but distinct from, the class of missing data problems with data missing at random (of which the average treatment effect (ATE) estimand is a special case). Our estimator also possesses a double robustness property. Our procedure may be used to efficiently estimate, among other objects, the ATT, the two-sample instrumental variables model (TSIV), counterfactual distributions, poverty maps, and semiparametric difference-in-differences. In an empirical application, we use our procedure to characterize residual Black–White wage inequality after flexibly controlling for “premarket” differences in measured cognitive achievement. Supplementary materials for this article are available online.
Efficient estimation of data combination models by the method of auxiliary-to-study tilting (AST)
Creators: name: Graham, Bryan S.
name: Pinto, Cristine Campos De Xavier
name: Egel, Daniel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology

description: We propose a locally efficient estimator for a class of semiparametric data combination problems. A leading estimand in this class is the Average Treatment Effect on the Treated (ATT). Data combination problems are related to, but distinct from, the class of missing data problems analyzed by Robins, Rotnitzky and Zhao (1994) (of which the Average Treatment Effect (ATE) estimand is a special case). Our estimator also possesses a double robustness property. Our procedure may be used to efficiently estimate, among other objects, the ATT, the two-sample instrumental variables model (TSIV), counterfactual distributions, poverty maps, and semiparametric difference-in-differences. In an empirical application we use our procedure to characterize residual Black-White wage inequality after flexibly controlling for ‘pre-market’ differences in measured cognitive achievement as in Neal and Johnson (1996).
TAp73 transcriptionally represses BNIP3 expression
Creators: name: Petrova, Varvara
name: Mancini, Mara
name: Agostini, Massimiliano
name: Knight, Richard A
name: Annicchiarico-Petruzzelli, Margherita
name: Barlev, Nikolai A
name: Melino, Gerry
name: Amelio, Ivano
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: TAp73 is a tumour suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumours might lead to reduced DNA damage response, cell cycle arrest and apoptosis. Carcinogen-induced TAp73−/− tumours display also increased angiogenesis, associated to hyperactivition of hypoxia inducible factor signaling. Here, we show that TAp73 suppresses BNIP3 expression, directly binding its gene promoter. BNIP3 is a hypoxia responsive protein, involved in a variety of cellular processes, such as autophagy, mitophagy, apoptosis and necrotic-like cell death. Therefore, through different cellular process altered expression of BNIP3 may differently contribute to cancer development and progression. We found a significant upregulation of BNIP3 in human lung cancer datasets, and we identified a direct association between BNIP3 expression and survival rate of lung cancer patients. Our data therefore provide a novel transcriptional target of TAp73, associated to its antagonistic role on HIF signaling in cancer, which might play a role in tumour suppression.
Improved Time-Resolved Measurements of Inorganic Ions in Particulate Matter by PILS-IC Integrated with a Sample Pre-Concentration System
Creators: name: Perrino, Cinzia
name: Catrambone, Maria
name: Farao, Carmela
name: Salzano, Roberto
name: Esposito, Giulio
name: Giusto, Marco
name: Montagnoli, Mauro
name: Marini, Angelo
name: Brinoni, Mirko
name: Simonetti, Giulia
name: Canepari, Silvia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine
subject: Engineering

description: A particle-into-liquid sampler coupled with ion chromatograph (PILS-IC) for the on-line measurement of inorganic ions has been modified by the insertion of two ion-exchange pre-concentration cartridges that enrich the sample during the period of the IC analysis. The limits of detection of the modified instrument were 10–15 times lower and the time coverage 24 higher (from 2 to 48 minutes per hour) than those of the original PILS-IC set-up. The instrumental performance in terms of recovery and break-through volume from the cartridges was satisfactory.The modified PILS-IC was operated in comparison with a diffusion denuder line and with a High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-TOF-AMS) during a short intensive measurement period organized in the framework of the Co-operative programme for monitoring and evaluation of the long-range transmission of the air pollutants in Europe (EMEP). The instrument showed a quantitative response in agreement with the results of the diffusion lines, and an ability to trace fine concentration variations not so different from the performance of the much more complex HR-TOF-AMS. From the time patterns of the ion concentrations measured by the modified PILS-IC it was possible to obtain useful information about the variations in the air quality and in the strength of the PM sources.
The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase
Creators: name: Namkoong, Sim
name: Lee, Kang Il
name: Lee, Jin I
name: Rackhyun Park
name: Lee, Eun-Ju
name: Ik-Soon Jang
name: Junsoo Park
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Meta Science
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: The PKA-CREB signaling pathway is involved in many cellular processes including autophagy. Recent studies demonstrated that PKA-CREB inhibits autophagy in yeast; however, the role of PKA-CREB signaling in mammalian cell autophagy has not been fully characterized. Here, we report that the integral membrane protein ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase (v-ATPase). The ITM2A promoter contains a CRE element, and mutation at the CRE consensus site decreases the promoter activity. Forskolin treatment and PKA expression activate the ITM2A promoter confirming that ITM2A expression is dependent on the PKA-CREB pathway. ITM2A expression results in the accumulation of autophagosomes and interferes with autolysosome formation by blocking autophagic flux. We demonstrated that ITM2A physically interacts with v-ATPase and inhibits lysosomal function. These results support the notion that PKA-CREB signaling pathway regulates ITM2A expression, which negatively regulates autophagic flux by interfering with the function of v-ATPase.
TAp73 transcriptionally represses BNIP3 expression
Creators: name: Petrova, Varvara
name: Mancini, Mara
name: Agostini, Massimiliano
name: Knight, Richard A
name: Annicchiarico-Petruzzelli, Margherita
name: Barlev, Nikolai A
name: Melino, Gerry
name: Amelio, Ivano
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: TAp73 is a tumor suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumors might lead to reduced DNA damage response, cell cycle arrest and apoptosis. Carcinogen-induced TAp73−/− tumors display also increased angiogenesis, associated to hyperactivition of hypoxia inducible factor signaling. Here, we show that TAp73 suppresses BNIP3 expression, directly binding its gene promoter. BNIP3 is a hypoxia responsive protein, involved in a variety of cellular processes, such as autophagy, mitophagy, apoptosis and necrotic-like cell death. Therefore, through different cellular process altered expression of BNIP3 may differently contribute to cancer development and progression. We found a significant upregulation of BNIP3 in human lung cancer datasets, and we identified a direct association between BNIP3 expression and survival rate of lung cancer patients. Our data therefore provide a novel transcriptional target of TAp73, associated to its antagonistic role on HIF signaling in cancer, which might play a role in tumor suppression.
TAp73 transcriptionally represses BNIP3 expression
Creators: name: Petrova, Varvara
name: Mancini, Mara
name: Agostini, Massimiliano
name: Knight, Richard A
name: Annicchiarico-Petruzzelli, Margherita
name: Barlev, Nikolai A
name: Melino, Gerry
name: Amelio, Ivano
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: TAp73 is a tumor suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumors might lead to reduced DNA damage response, cell cycle arrest and apoptosis. Carcinogen-induced TAp73−/− tumors display also increased angiogenesis, associated to hyperactivition of hypoxia inducible factor signaling. Here, we show that TAp73 suppresses BNIP3 expression, directly binding its gene promoter. BNIP3 is a hypoxia responsive protein, involved in a variety of cellular processes, such as autophagy, mitophagy, apoptosis and necrotic-like cell death. Therefore, through different cellular process altered expression of BNIP3 may differently contribute to cancer development and progression. We found a significant upregulation of BNIP3 in human lung cancer datasets, and we identified a direct association between BNIP3 expression and survival rate of lung cancer patients. Our data therefore provide a novel transcriptional target of TAp73, associated to its antagonistic role on HIF signaling in cancer, which might play a role in tumor suppression.
Green Open Access Article Archiving Policy Infographic
Creators: name: Bilby, Mark G.
name: Vazquez, Karen
Publisher: name: Zenodo
Year: 2017

description: A myth vs. fact approach to answer the most commonly raised concerns about a UC/Harvard style Green Article Archiving policy. Concept and content by Mark G. Bilby, and graphic design and layout by Karen Vazquez. We used this in our campus policy advocacy efforts at Cal State Fullerton and also had it accepted as a conference poster at the Digital Initiatives Symposium at the University of San Diego in 2017.
Molecular mechanism of statin-mediated LOX-1 inhibition
Creators: name: Biocca, Silvia
name: Iacovelli, Federico
name: Matarazzo, Sara
name: Vindigni, Giulia
name: Oteri, Francesco
name: Desideri, Alessandro
name: Falconi, Mattia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Chemistry
subject: Pharmacology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Statins are largely used in clinics in the treatment of patients with cardiovascular diseases for their effect on lowering circulating cholesterol. Lectin-like oxidized low-density lipoprotein (LOX-1), the primary receptor for ox-LDL, plays a central role in the pathogenesis of atherosclerosis and cardiovascular disorders. We have recently shown that chronic exposure of cells to lovastatin disrupts LOX-1 receptor cluster distribution in plasma membranes, leading to a marked loss of LOX-1 function. Here we investigated the molecular mechanism of statin-mediated LOX-1 inhibition and we demonstrate that all tested statins are able to displace the binding of fluorescent ox-LDL to LOX-1 by a direct interaction with LOX-1 receptors in a cell-based binding assay. Molecular docking simulations confirm the interaction and indicate that statins completely fill the hydrophobic tunnel that crosses the C-type lectin-like (CTLD) recognition domain of LOX-1. Classical molecular dynamics simulation technique applied to the LOX-1 CTLD, considered in the entire receptor structure with or without a statin ligand inside the tunnel, indicates that the presence of a ligand largely increases the dimer stability. Electrophoretic separation and western blot confirm that different statins binding stabilize the dimer assembly of LOX-1 receptors in vivo. The simulative and experimental results allow us to propose a CTLD clamp motion, which enables the receptor-substrate coupling. These findings reveal a novel and significant functional effect of statins.
title: Black Springfield: A Historical Study
title: Black Springfield: A Historical Study
titleType: AlternativeTitle
Creators: name: Kazini, Imani
Publisher: name: University of Massachusetts Amherst
Year: 1977
Subjects: subject: Afro-American Studies
subject: Springfield Massachusetts
subject: Urban History
subject: Black History

description: Part 1 of a two-part history of African Americans in Springfield, Massachusetts. This article covers the period 1636 to 1900. It was written by an undergraduate Afro-American Studies student at UMass Amherst as her senior thesis.
The effect of corn–soybean rotation on the NDVI-based drought indicators: a case study in Iowa, USA, using Vegetation Condition Index
Creators: name: Yagci, Ali Levent
name: Liping Di
name: Meixia Deng
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Astronomy, Astrophysics, Space Science
subject: Ecology
subject: Earth and Environmental Sciences

description: Satellite remote sensing has become a popular tool to analyze agricultural drought through terrestrial vegetation health conditions using the normalized difference vegetation index (NDVI). Drought monitoring techniques using remote sensing-based drought indices assume that vegetation conditions vary year-to-year due to prevailing weather conditions (e.g., precipitation and temperature), and current conditions are evaluated based on the deviation from the long-term statistics such as mean, minimum, or maximum. However, the rotation between agricultural crops (e.g., corn and soybeans) implies that this assumption may not hold, as each crop type may have distinct phenological variability across the growing season. In this study, the effect of crop rotation between corn and soybeans on the accuracy of the NDVI-based agricultural drought monitoring was investigated in Iowa, USA. The vegetation condition index (VCI), which is derived from NDVI, was selected to demonstrate the impact of crop rotation. The standard precipitation index (SPI) and official crop yield statistics were used as independent validation of the drought information acquired by these indices. The results suggested that the NDVI alone was not able to distinguish drought-related vegetation stress from vegetation changes caused by crop rotation between corn and soybeans. It was found that the integration of land cover with NDVI greatly improved the agricultural drought information obtained by the VCI over the crop-rotated agricultural fields in Iowa.
Revisiting Access to Cultural Heritage in the Public Domain: EU and International Developments
Creators: name: Wallace, Andrea
name: Euler, Ellen
Publisher: name: Zenodo
Year: 2020
Subjects: copyright, public domain, cultural heritage organisations, open access, DSM Directive, PSI Directive

description: In the past year, a number of legal developments have accelerated discussions around whether intellectual property rights can be claimed in materials generated during the reproduction of public domain works. This article analyses those developments, focusing on the 2018 German Federal Supreme Court decision Museumsfotos, Article 14 of the 2019 Copyright and Related Rights in the Digital Single Market Directive, and relevant provisions of the 2019 Open Data and the Re-use of Public Sector Information Directive. It reveals that despite the growing consensus for protecting the public domain, there is a lack of practical guidance throughout the EU in legislation, jurisprudence, and literature on what reproduction media might attract new intellectual property rights, from scans to photography to 3D data. This leaves ample room for copyright to be claimed in reproduction materials produced by new technologies. Moreover, owners remain able to impose other restrictive measures around public domain works and data, like onsite photography bans, website terms and conditions, and exclusive arrangements with third parties. This article maps out these various legal gaps. It argues the pro-open culture spirit of the EU Directives should be embraced and provides guidance for Member States and heritage institutions around national implementation.
figshare for institutions brochure
Creators: name: Hyndman, Alan
name: Hahnel, Mark
name: Serediuc, George
name: Apetrei, Florin
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: figshare for institutions is a research data management platform that helps institutions store, share and manage their research. This document gives an overview of the 4 modules of functionality, data management, data dissemination, user group administration, reporting and statistics.
Tetra(μ3-hydroxo) bridged copper(II) tetranuclear cubane complexes: synthesis, crystal structure, and DNA binding studies
Creators: name: Rasoul Vafazadeh
name: Willis, Anthony C.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Chemistry
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The tridentate Schiff base H2L was synthesized by the condensation of equimolar amount of 1-amino-2-propanol and salicylaldehyde. The reaction of H2L with an equimolar amount of Cu(CH3COO)2·H2O in methanol leads to the formation of the tetranuclear Cu4L4, 1. However, reaction of equimolar amount of H2L, copper(II) acetate, and 2,4,6-trimethylaniline in methanol forms a mixture of products which includes a discrete mononuclear complex Cu(L′)2, 2m (where HL′ is a bidentate ligand), in addition to the tetranuclear Cu4L4 species, 2c. In both tetranuclear cubane species, the tridentate H2L is both a chelating and a bridging ligand, after deprotonation of the enolic and the phenolic OH. The copper(II) centers are five-coordinate with a [N, O4] donor set from the ligands. The coordination geometry about each copper is distorted square pyramidal with one nitrogen and two oxygen from one ligand and two oxygen from adjacent ligands in the next unit of the cubane. In mononuclear 2m, the ligand is bidentate and the coordination geometry around copper(II) is square planar. The absorption spectra strongly suggest that tetranuclear 1 interacts with CT-DNA.
Tetra(μ3-hydroxo) bridged copper(II) tetranuclear cubane complexes: Synthesis, crystal structure and DNA binding studies
Creators: name: Rasoul Vafazadeh
name: Willis, Anthony C.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Chemistry
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The tridentate Schiff base H2L was synthesized by condensation of equimolar amount of 1-amino-2-propanol and salicylaldehyde. The reaction of H2L with an equimolar amount of Cu(CH3COO)2·H2O in methanol leads to formation of the tetranuclear Cu4L4, 1. However, reaction of equimolar amount of H2L, copper(II) acetate and 2,4,6-trimethylaniline in methanol forms a mixture of products which include a discrete mononuclear complex Cu(L׳)2, 2m (where HL׳ is a bidentate ligand), in addition to the tetranuclear Cu4L4 species, 2c. In both tetranuclear cubane species the tridentate H2L is both a chelating and a bridging ligand, after deprotonation of the enolic and the phenolic OH. The copper(II) centers are five-coordinate with a [N, O4] donor set from the ligands. The coordination geometry about each copper is distorted square pyramidal with one nitrogen and two oxygens from one ligand and two oxygens from adjacent ligands in the next unit of the cubane. In mononuclear 2m, the ligand is bidentate and the coordination geometry around copper(II) is square planar. The absorption spectra strongly suggest that tetranuclear 1 interacts with CT-DNA.
É necessário tipificar todos os crimes no Direito Brasileiro_ Explicação para leigos – LEX EDITORA_removed.pdf
Creators: name: Teles Rocha, Leandro
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 480503
subject: Criminal procedure
classificationCode: 480401
subject: Criminal law
classificationCode: 480702
subject: Constitutional law

description: O Direito Penal Brasileiro exige a tipificação de todos os crimes, seguindo o princípio da legalidade.Tipificação dos Crimes- O Direito Penal Brasileiro é numerus clausus, ou seja, crimes devem estar tipificados na lei.- O princípio da anterioridade da lei penal afirma que não há crime sem lei anterior que o defina.- A legislação penal é de competência privativa da União, conforme o Art. 22 da Constituição.Sistema Jurídico- O Brasil adota o sistema jurídico Romano-Germânico, fundamentado em leis e tratados internacionais.- Diferente da common law, que se baseia em costumes e jurisprudência, como nos EUA e Reino Unido.Importância da Atualização Legislativa- O trabalho do Deputado Federal Kim Kataguiri é destacado na atualização da legislação penal.- Somente o Congresso Nacional pode legislar sobre questões penais, garantindo a harmonia entre os Poderes da União.
Role of aquifer media in determining the fate of polycyclic aromatic hydrocarbons in the natural water and sediments along the lower Ganges river basin
Creators: name: Srimanti Duttagupta
name: Abhijit Mukherjee
name: Joyanto Routh
name: Devi, Laxmi Gayatri
name: Animesh Bhattacharya
name: Jayanta Bhattacharya
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Groundwater-sourced drinking water quality in South Asia, specifically India, is extremely stressed, mostly from the presence of many pervasive and geogenic pollutants. The presence and behavior of anthropogenic pollutants like polycyclic aromatic hydrocarbons (PAHs) are poorly investigated on a regional or basin-wide scale. The present study provides one of the first documentation of the presence and behavior of PAH in the aquifer sediments in the Ganges river basin. Lower and medium molecular weight PAHs, e.g., naphthalene, phenanthrene, and fluoranthene were detected in 79, 36, and 13% of samples (n = 25). The PAH level in groundwater was approximately five times lower than river water. The sorption behavior of PAHs were studied in experiments in presence/absence of organic carbon and by simulating advective transport of low to medium molecular weight PAHs, e.g., naphthalene, phenanthrene, and fluoranthene in aquifer sediments collected from agricultural, peri-urban, and urban areas. Naphthalene and phenanthrene adsorbed on quartz and kaolinite, but not on clay minerals like kaolinite. Fluoranthene adsorbed more favorably on kaolinite. Numerical modeling of the advective transport of PAHs in aquifers suggest up to 25 times faster movement of pollutants from irrigation-induced pumping, indicating the strong control of hydraulics on the spatial distribution of PAHs in subsurface.
Comparative time-based intermediates study of ozone oxidation of 4-chloro- and 4-nitrophenols followed by LCMS-TOF
Creators: name: Akharame, Michael Ovbare
name: Olalekan Siyanbola Fatoki
name: Opeolu, Beatrice Olutoyin
name: Olorunfemi, Daniel Ikudayisi
name: Ogheneochuko Utieyin Oputu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Greater insights on the degradation pathways and intermediates formed during the oxidation of organics can be achieved by more suitable and compatible instrumentation. In our research, we sought to explore the relative advantages of the liquid chromatography coupled to a time of flight mass spectrometer (LCMS-TOF) technique for the comparative time-based degradation intermediates and pathways of 4-chlorophenol (4CP) and 4-nitrophenol (4NP). The ozonation of the analytes solution (100 mL of 2 x 10−3 M) was done in a sintered glass reactor, with an ozone dose of 0.14 mg min−1 (O2/O3 10 mL/min). The comparative oxidation results revealed that the 4-chloro- and 4-nitrocatechol pathways via hydroxylation were the major degradation route for 4CP and 4NP. Catechol intermediate was present as a primary breakdown product for the two analytes. Hydroquinone was observed as transient degradation intermediate for 4CP, but was absent for 4NP. Rather, a novel ozonation intermediate 2, 4-dinitrophenol was identified which was further oxidized to 3,6-dinitrocatechol. Several dimer products were identified in the oxidation processes, favored by alkaline conditions with more versatility shown by 4CP. The study provided a great insight into the ozone degradation intermediates and pathways, with some intermediates scarce in literature identified.
INTENSIFY: A SYNTACTIC-BASED ANALYSIS APPROACH FOR AUTOMATIC APIS INTEGRATION POINTS DISCOVERY IN SYSTEMS-OF-SYSTEMS
Creators: name: Borges, Marcos Vinicius de Freitas
Publisher: name: Zenodo
Year: 2023
Subjects: sos
api
approach
syntactic
analysis

description: This poster, titled "INTENSIFY", is a semi-automatic method designed to identify potential integration points of Constituent System (CS) in System-of-Systems (SoS) using syntactic similarity analysis of their Application Programming Interfaces (APIs). It was presented at the Brazilian Conference on Software: Practice and Theory (CBSoft) during the Third LATAM School in Software Engineering.
Analysing half-lives for pesticide dissipation in plants
Creators: name: R.E. Jacobsen
name: P. Fantke
name: S. Trapp
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry
subject: Biophysics

description: Overall dissipation of pesticides from plants is frequently measured, but the contribution of individual loss processes is largely unknown. We use a pesticide fate model for the quantification of dissipation by processes other than degradation. The model was parameterised using field studies. Scenarios were established for Copenhagen/Denmark and Shanghai/PR China, and calibrated with measured results. The simulated dissipation rates of 42 pesticides were then compared with measured overall dissipation from field studies using tomato and wheat. The difference between measured overall dissipation and calculated dissipation by non-degradative processes should ideally be contributable to degradation in plants. In 11% of the cases, calculated dissipation was above the measured dissipation. For the remaining cases, the non-explained dissipation ranged from 30% to 83%, depending on crop type, plant part and scenario. Accordingly, degradation is the most relevant dissipation process for these 42 pesticides, followed by growth dilution. Volatilisation was less relevant, which can be explained by the design of plant protection agents. Uptake of active compound from soil into plants leads to a negative dissipation process (i.e. a gain) that is difficult to quantify because it depends largely on interception, precipitation and plant stage. This process is particularly relevant for soluble compounds.
RAVE RAP FRP July 2019 to 2021 Merged Dataset
Creators: name: Kumler (Bonfanti), Christina
Publisher: name: Zenodo
Year: 2024

description: The RAP_RAVE_df_2019_2021.csv is a file that contains a point-wise machine learning dataset. It was created by merging data the RAVE fire radiative power dataset, the rapid refresh (RAP) weather model dataset, time of the RAVE detection to the nearest hour, and location information. The RAVE data is aggregated over a 13km resolution grid, with identical structure to the RAP grid, over the hour indicated in "hour." The data is not provided in grid format, however. It is a tabular csv where if there was a non-zero fire radiative power (FRP) from the RAVE dataset, it is listed as an entry andmerged with the corresponding RAP information. The lat and lon provided are the RAP lat and lon points. It is intended to be used to train a machine learning model to forecast hourly FRP

The RF_RAP_RAVE_all_vars.sav file is a trained ranfom forest model created based on the following credentials that can be imported into a python program. The following list of inputs must match and are defined with corresponding rap variable names in the collab notebook. Note that "24hr_roll_frp" corresponds to the 24 hour rolling mean of FRP up to the hour before desired modeling period: 

Training dimensions:   [195707, 26]   

Testing dimensions:  [83875, 26]   

Credentials of input data: Rolling 24 hour FRP mean > 0   

Withheld dates for blind validation  08-01-2019 through 11-01-2019 and 08-25-2020 through 09-25-2020   

Model structure: RandomForestRegressor(n_estimators = 1000, random_state = 30)

Inputs must be: 'lat', 'lon', 'hour', 'temp2m', 'wind_gust', 'precip', 'dpt', 'uwind', 'vwind',                                 'temp_surf', 'snod', 'spfh', 'pwat', 'weasd', 'dswrf', 'uswrf', 'dlwrf', 'ulwrf',                                  'cape', 'ltng', 'tsoil', 'soilw', 'vgtyp', 'sotyp', '24hr_roll_frp'

Output variable will be an hourly FRP value for that input's hour, latitude, and longitude.
Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats
Creators: name: Iqbal, Zahid
name: Chinedu Imo1*,
name: Friday O. Uhegbu1
name: Ifeanacho Nkeiruka G.2,
name: Egbeigwe Otito1 And Ezekwe A. S
Publisher: name: figshare
Year: 2015
Subjects: subject: Pathology
subject: Education
subject: Microbiology
subject: FOS: Biological sciences
subject: Botany
subject: Biological Engineering
subject: Molecular Biology
subject: Genetics

description: This study examined the biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymes ALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. Protein concentration increased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract.The effect of the G. latifolium leaf extract seems to be dose dependent on the liver enzymes and protein concentration measured. The results showed that acetaminophen-induced hepatic toxicity in the wistar albino rats as observed in the negative control was reversed with the administration of the leaf extract of Gongronema latifolium (in groups 3, 4 and 5) in the test animals. The histological analysis of the liver showed that the extract had a normalising effect on the effected liver. These results indicate that the leaf extract of Gongronema latifolium exhibits biochemical and histological changes and can be used against some hepatic inflammations.
Synthesis of Some Functionalized Peptomers via Ugi Four-Component Reaction
Creators: name: Silva, Eduardo H. B.
name: Ponte, Gino Del
name: Donate, Paulo M.
name: Emery, Flavio S.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry

description: This article describes the synthesis of new peptomers through a simple and efficient route using a one-pot Ugi four-component reaction. The synthesis started from either carboxylic acids or protected amino acids, primary amines, aldehydes, and isocyanides in anhydrous methanol and proceeded under stirring at room temperature. The reaction produced several functionalized peptomers in good yields (67–80%). These compounds are versatile multifunctional intermediates that can be further unprotected or functionalized to generate new molecules with numerous applications in the field of biomedicine.
Synthesis of Some Functionalized Peptomers via Ugi Four-Component Reaction
Creators: name: Silva, Eduardo H. B.
name: Ponte, Gino Del
name: Donate, Paulo M.
name: Emery, Flavio S.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry

description: This paper describes the synthesis of new peptomers through a simple and efficient route using a one-pot Ugi four-component reaction. The synthesis started from either carboxylic acids or protected amino acids, primary amines, aldehydes, and isocyanides in anhydrous methanol, and proceeded under stirring at room temperature. The reaction produced several functionalized peptomers in high yields (67-80%). These compounds are versatile multifunctional intermediates that can be further unprotected or functionalized to generate new molecules with numerous applications in the field of biomedicine.
Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response
Creators: name: Dae-Gyun Ahn
name: Sharif, Tanveer
name: Chisholm, Kenneth
name: Devanand M Pinto
name: Gujar, Shashi A
name: Lee, Patrick WK
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111714 Mental Health
subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Neuroscience
subject: Cell Biology
subject: Biochemistry

description: ABSTRACTDysregulation of Ras signaling is the major cause of various cancers. Aberrant Ras signaling, however, provides a favorable environment for many viruses, making them suitable candidates as cancer-killing therapeutic agents. Susceptibility of cancer cells to such viruses is mainly due to impaired type I interferon (IFN) response, often as a result of activated Ras/ERK signaling in these cells. In this study, we searched for cellular factors modulated by Ras signaling and their potential involvement in promoting viral oncolysis. We found that upon Ras transformation of NIH-3T3 cells, the N-terminus of Nogo-B (reticulon 4) was proteolytically cleaved. Interestingly, Nogo knockdown (KD) in non-transformed and Ras-transformed cells both enhanced virus-induced IFN response, suggesting that both cleaved and uncleaved Nogo can suppress IFN response. However, pharmacological blockade of Nogo cleavage in Ras-transformed cells significantly enhanced virus-induced IFN response, suggesting that cleaved Nogo contributes to enhanced IFN suppression in these cells. We further showed that IFN suppression associated with Ras-induced Nogo-B cleavage was distinct from but synergistic with that associated with an activated Ras/ERK pathway. Our study therefore reveals an important and novel role of Nogo-B and its cleavage in the suppression of anti-viral immune responses by oncogenic Ras transformation.
Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response
Creators: name: Dae-Gyun Ahn
name: Sharif, Tanveer
name: Chisholm, Kenneth
name: Devanand M Pinto
name: Gujar, Shashi A
name: Lee, Patrick WK
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111714 Mental Health
subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Neuroscience
subject: Cell Biology
subject: Biochemistry

description: Dysregulation of Ras signaling is the major cause of various cancers. Aberrant Ras signaling, however, provides a favorable environment for many viruses, making them suitable candidates as cancer-killing therapeutic agents. Susceptibility of cancer cells to such viruses is mainly due to impaired type I interferon (IFN) response, often as a result of activated Ras/ERK signaling in these cells. In this study, we searched for cellular factors modulated by Ras signaling and their potential involvement in promoting viral oncolysis. We found that upon Ras transformation of NIH-3T3 cells, the N-terminus of Nogo-B (reticulon 4) was proteolytically cleaved. Interestingly, Nogo knockdown (KD) in non-transformed and Ras-transformed cells both enhanced virus-induced IFN response, suggesting that both cleaved and uncleaved Nogo can suppress IFN response. However, pharmacological blockade of Nogo cleavage in Ras-transformed cells significantly enhanced virus-induced IFN response, suggesting that cleaved Nogo contributes to enhanced IFN suppression in these cells. We further showed that IFN suppression associated with Ras-induced Nogo-B cleavage was distinct from but synergistic with that associated with an activated Ras/ERK pathway. Our study therefore reveals an important and novel role of Nogo-B and its cleavage in the suppression of anti-viral immune responses by oncogenic Ras transformation.