cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Experimentum crucis for electromagnetic response of metals to evanescent waves and the Casimir puzzle
Creators: name: Klimchitskaya, G. L.
name: Mostepanenko, V. M.
name: Svetovoy, V. B.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It is well known that the Casimir force calculated at large separations using the Lifshitz theory differs by a factor of 2 for metals described by the Drude or plasma models. We argue that this difference is entirely determined by the contribution of transverse electric (s) evanescent waves. Taking into account that there is a lack of experimental information on the electromagnetic response of metals to low-frequency evanescent waves, we propose an experiment on measuring the magnetic field of an oscillating magnetic dipole spaced in vacuum above a thick metallic plate. According to our results, the lateral components of this field are governed by the transverse electric evanescent waves and may vary by orders of magnitude depending on the model describing the permittivity of the plates used in calculations and the oscillation frequency of the magnetic dipole. Measuring the lateral component of the magnetic field for typical parameters of the magnetic dipole designed in the form of 1-mm coil, one could either validate or disprove applicability of the Drude model as a response function of metal in the range of low-frequency evanescent waves. This will elucidate the roots of the Casimir puzzle lying in the fact that the theoretical predictions of the Lifshitz theory using the Drude model are in contradiction with the high-precision measurements of the Casimir force at separations exceeding 150 nm. Possible implications of the suggested experiment for a wide range of topics in optics and condensed matter physics dealing with evanescent waves are discussed.
description: 30 pages, 7 figures
Factors in AIDS Dementia Complex Trial Design: Results and Lessons from the Abacavir Trial
Creators: name: Sacktor, Ned
name: Clifford, David B
name: Brown, Steve
name: Halman, Mark
name: Brew, Bruce J
name: Atkinson, Hamp
name: Arthur, Justin C. Mc
name: Catalan, Jose
name: Simpson, David
name: Hall, Colin
name: Romero, Carmen
name: Symonds, William
name: Price, Richard W
name: Power, Christopher
name: Marder, Karen
name: Torres, Gabriel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: To determine the efficacy of adding abacavir (Ziagen, ABC) to optimal stable background antiretroviral therapy (SBG) to AIDS dementia complex (ADC) patients and address trial design.
Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases
Creators: name: Ding, Feng
name: Gwanmesia, Kenneth N.
name: Dokholyan, Nikolay V.
name: Khare, Sagar D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Expansion of polyglutamine (polyQ) tracts in proteins results in protein aggregation and is associated with cell death in at least nine neurodegenerative diseases. Disease age of onset is correlated with the polyQ insert length above a critical value of 35–40 glutamines. The aggregation kinetics of isolated polyQ peptides in vitro also shows a similar critical-length dependence. While recent experimental work has provided considerable insights into polyQ aggregation, the molecular mechanism of aggregation is not well understood. Here, using computer simulations of isolated polyQ peptides, we show that a mechanism of aggregation is the conformational transition in a single polyQ peptide chain from random coil to a parallel β-helix. This transition occurs selectively in peptides longer than 37 glutamines. In the β-helices observed in simulations, all residues adopt β-strand backbone dihedral angles, and the polypeptide chain coils around a central helical axis with 18.5 ± 2 residues per turn. We also find that mutant polyQ peptides with proline-glycine inserts show formation of antiparallel β-hairpins in their ground state, in agreement with experiments. The lower stability of mutant β-helices explains their lower aggregation rates compared to wild type. Our results provide a molecular mechanism for polyQ-mediated aggregation.
Differential Distributed Space-Time Coding with Imperfect Synchronization
Creators: name: Avendi, M. R.
name: Poorkasmaei, Sina
name: Jafarkhani, Hamid
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Differential distributed space-time coding (D-DSTC) has been considered to improve both diversity and data-rate in cooperative communications in the absence of channel information. However, conventionally, it is assumed that relays are perfectly synchronized in the symbol level. In practice, this assumption is easily violated due to the distributed nature of the relay networks. This paper proposes a new differential encoding and decoding process for D-DSTC systems with two relays. The proposed method is robust against synchronization errors and does not require any channel information at the destination. Moreover, the maximum possible diversity and symbol-by-symbol decoding are attained. Simulation results are provided to show the performance of the proposed method for various synchronization errors and the fact that our algorithm is not sensitive to synchronization error.
description: to appear in IEEE Globecom, 2014
Wigner time delays and Goos-Hänchen shifts of 2D quantum vortices scattered by potential barriers
Creators: name: Mazanov, Maxim
name: Bliokh, Konstantin Y.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We consider reflection and transmission of 2D quantum wavepackets with phase vortices (also known in optics as spatiotemporal vortex pulses) at potential step-like, delta-function, and rectangular barriers. The presence of a vortex significantly modifies the Wigner time delays and Goos-Hänchen shifts, previously studied for Gaussian-like wavepackets. In particular, the scattered wavepackets undergo non-zero time delays and lateral shifts even for purely real scattering coefficients, when the standard Wigner and Artmann formulae vanish. We derive analytical expressions for the vortex-induced times delays and spatial shifts of 2D vortices and verify these with numerical calculations of the Schrödinger equation. The time delays and shifts are resonantly enhanced in the vicinity of the critical-angle incidence for a step-like potential and near transmission resonances for a rectangular barrier.
description: 16 pages, 7 figures
Correction: Emergence of Protein Fold Families through Rational Design
Creators: name: Ding, Feng
name: Dokholyan, Nikolay V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Diverse proteins with similar structures are grouped into families of homologs and analogs, if their sequence similarity is higher or lower, respectively, than 20%–30%. It was suggested that protein homologs and analogs originate from a common ancestor and diverge in their distinct evolutionary time scales, emerging as a consequence of the physical properties of the protein sequence space. Although a number of studies have determined key signatures of protein family organization, the sequence-structure factors that differentiate the two evolution-related protein families remain unknown. Here, we stipulate that subtle structural changes, which appear due to accumulating mutations in the homologous families, lead to distinct packing of the protein core and, thus, novel compositions of core residues. The latter process leads to the formation of distinct families of homologs. We propose that such differentiation results in the formation of analogous families. To test our postulate, we developed a molecular modeling and design toolkit, Medusa, to computationally design protein sequences that correspond to the same fold family. We find that analogous proteins emerge when a backbone structure deviates only 1–2 Å root-mean-square deviation from the original structure. For close homologs, core residues are highly conserved. However, when the overall sequence similarity drops to ~25%–30%, the composition of core residues starts to diverge, thereby forming novel families of protein homologs. This direct observation of the formation of protein homologs within a specific fold family supports our hypothesis. The conservation of amino acids in designed sequences recapitulates that of the naturally occurring sequences, thereby validating our computational design methodology.
مقایسه میزان رضایت مندی ساکنان از مجتمع های مسکن مهر دولتی و خود مالک (مطالعه موردی: شهر آمل)
Publisher: name: دانشگاه کردستان
Year: 2018

description: رضایت از محیط مسکونی، عامل مهمی برای دستیابی به رضایت از زندگی است. یکی از مهمترین اقدامات دولت برای\nتأمین مسکن مناسب برای طبقات با درآمد کم و متوسط، سیاست ساخت و عرضه مسکن مهر است. چنین به نظر میرسد\nکه این سیاست تأ کید ویژه ای بر جنبه های کمی مسکن داشته و بیش از توجه به جنبه های اجتماعی، بعد اقتصادی\nمسکن را نشانه گرفته است. پروژه مسکن مهر، بزرگترین طرح ملی مسکن میباشد که به علت ماهیت گسترده و نو بودن\nآن در کشور نیاز به بررسی نتایج حاصل از این تجربه دارد. هدف این مقاله ارزیابی و مقایسه میزان رضایت مندی ساکنان از\nمجتمع های مسکن مهر دولتی و خودمالک در شهر آمل است. این مقاله از نظر روش شناسی از نوع توصیفی_تحلیلی است\nبرای جمع آوری اطلاعات مورد نیاز، از روش های کتابخانه ای و اسنادی_پیمایشی استفاده شده است. حجم نمونه برآورد\nشده به روش کوکران برابر253نفر بوده است. برای شناخت و تحلیل وضعیت رضایتمندی ساکنان از مجتمع های مسکن\nمهر شهر آمل، با توجه به غیرنرمال بودن داده ها از آزمون های ناپارامتریک استفاده شده است. برای تحلیل و شناخت وضع\nمیزان رضایت مندی از آزمون باینومیال، برای مقایسه میزان رضایتمندی در دو مسکن مهر دولتی و خصوصی از آزمون\nیومن ویتنی و برای رتبه بندی انواع رضایت از آزمون فریدمن استفاده شده است. یافته ها نشان می دهند که در مسکن مهر\nدولتی، در هیچ مؤلفه ای رضایت وجود ندارد. در مسکن مهر خودمالک نیز نارضایتی از مؤلفه های تسهیلات مجتمع و دید\nو منظر مشاهده می شود. در مورد بقیه مؤلفه ها، رضایت یا عدم رضایت از هیچ یک از مؤلفه ها معنیدار نمی باشد. نتایج\nآزمون یومن ویتنی نشان میدهد که در بین تمامی مؤلفه ها، بین مسکن مهر دولتی و خودمالک تفاوت معنیداری وجود\nدارد
Effects of global charge conservation on time evolution of cumulants of conserved charges in relativistic heavy ion collisions
Creators: name: Sakaida, Miki
name: Asakawa, Masayuki
name: Kitazawa, Masakiyo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We investigate the effect of the global charge conservation on the cumulants of conserved charges observed in relativistic heavy ion collisions in a finite rapidity window, $Δη$, with a special emphasis on the time evolution of fluctuations in the hadronic medium. It is argued that the experimental result of the net-electric charge fluctuation observed by ALICE does not receive effects from the global charge conservation, because of the finite diffusion distance of charged particles in the hadronic stage. We emphasize that the magnitude of the effect of the global charge conservation can be estimated experimentally by combining the information on the $Δη$ dependences of various cumulants of conserved charges, similarly to other dynamical properties of the hot medium.
description: 9 pages, 6 figures
برنامه ریزی راهبردی گردشگری شهری با رویکرد بازآفرینی فرهنگ مبنا در بافت های تاریخی (نمونه موردی: بافت قدیم شهر رشت)
Publisher: name: دانشگاه کردستان
Year: 2018

description: بازآفرینی فرهنگ مبنا و گردشگری فرهنگی، دو روی سکه نوسازی بافت های ارزشمند شهری محسوب می شوند؛ اولی فرایندی همه جانبه برای نجات بافت قدیم شهر از اضمحلال کالبد و فعالیت و دومی رهیافتی کارآمد با بُن مایه مشارکت مردم، میراث فرهنگی و هنر در بسیج نیروهای اجتماعی و فرهنگی بافت قلمداد می شوند. در این مقاله تعامل این دو در چارچوب برنامه ریزی راهبردی توسعه گردشگری فرهنگیِ بافت قدیم شهر رشت که محدوده محلات زاهدان و ساغریسازان را در بر می گیرد، مورد کنکاش قرار گرفته است. روش تحقیق توصیفی_تحلیلی بوده و از ترکیبی از ابزارهای کیفی و کمی شامل پرسشنامه و جداول تحلیل عوامل درونی و بیرونی برای طبقه بندی و تجزیه و تحلیل داده ها استفاده شده است. نتایج نشان می دهند که بافت قدیم شهر رشت با وجود دارا بودن منابع فرهنگی درون خود، به دلیل ضعف زیرساخت های گردشگری فرهنگی و عدم خلاقیت در کاربست فرهنگ و هنر در فرایند بازآفرینی فرهنگ مبنا نتوانسته از این منابع محلی بهره جوید. در راستای بهره گیری از این ظرفیت ها، راهبردهای دارای اولویت به همراه سیاست های اجرایی و برنامه اقدامات به منظور فعالسازی این ظرفیت ها برای توسعه گردشگری فرهنگی در عین حفاظت فعال از هویت و میراث بافت، تدوین شدند. ایجاد جاذبه های گردشگری نو و متفاوت با احیای سنت های آیینی و بومی بافت و ارائه به گردشگران، بهسازی بناهای تاریخی با تزریق فعالیت های جاذب برای گردشگران و پیاده­راه سازی محور دارای قابلیت بازار_ خواهر امام _زرجوب از جمله با اولویت ترین راهبردهای تدوین شده برای بازآفرینی فرهنگ مبنا از طریق گردشگری شهری در بافت قدیم شهر رشت محسوب می شوند
امکان سنجی تحقق شهر دوستدار سالمند (مطالعه موردی: شهر بوکان)
Publisher: name: دانشگاه کردستان
Year: 2018

description: افزایش طول عمر انسان­ها و اضافه شدن جمعیت سالمندان یکی از دسـتاوردهای قرن 21 بوده و سالخوردگی جمعیت پدیده­ای است که بـسیاری از جوامع بشری با آن روبه ­رو هستند و برخی دیگر در آینده­ای نزدیک با آن روبه ­رو خواهند شد. در ایران افزایش طول عمر همراه با کاهش نرخ موالید سبب پیری جمعیت شده است. با توجه به آمار جمعیتی، شهر بوکان نیز در سال های آینده با این پدیده مواجه خواهد شد. به همین دلیل پژوهش حاضر باهدف امکان سنجی تحقق شهر دوست دار سالمند در بوکان انجام  شده است.روش پژوهش از نوع توصیفی_پیمایشی باهدف کاربردی است. برای تحلیل داده ­ها از نرم ­افزار اس.پی.اس. و برای مقایسه میانگین شاخص ­ها از آزمون تی استفاده  شده است. با توجه به استفاده از پرسشنامه استاندارد سازمان بهداشت جهانی، روایی پرسشنامه مورد تأیید است. نتایج پژوهش نشان می­دهد از میان شاخص های اجتماعی، ارتباطی، فرهنگی_تفریحی و بهداشتی_درمانی موردبررسی به ترتیب بیشترین درصد نارضایتی مربوط به نبود فضای مناسب برای ارتباط با مراکز آموزشی مانند کامپیوتر، اینترنت، اطلاعات در مورد نرم افزارها و خدمات با حروف چاپی و بزرگ، نبود بازارچه های مخصوص خرید سالمندان و به خانواده ­ها در زمینه مراقبت از خود و سالمندان آموزش های لازم داده نمی­شود، می باشد. همچنین یافته­ های پژوهش نشان می­دهد که میانگین همه معیارهای موردبررسی (اجتماعی، ارتباطی، فرهنگی_تفریحی و بهداشتی_درمانی) پایین تر از حد استانداردند و تا رسیدن به سطح مطلوب فاصله زیادی دارند. بنابراین پیشنهاد می گردد متولیان امر برای ایجاد رفاه سالمندان در شاخص های دارای کمترین حد استاندارد همت بیشتری به خرج دهند و با رفع کاستی ها و تأمین نیازهای این قشر، رفاه و سرزندگی را برای سالمندان فراهم نمایند
Bound state of solution of Dirac-Coulomb problem with spatially dependent mass
Creators: name: Olgar, Eser
name: Dhahir, Hayder M.
name: Mutaf, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The bound state solution of Coulomb Potentials in the Dirac equation is calculated for position dependent mass function M(r) within the framework of asymptotic iteration method (AIM). The eigenfunctions are derived in terms of hypergeometric function and function generator equation of AIM.
Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions
Creators: name: Teotico, Denise G.
name: Temple, Brenda R. S.
name: Ding, Feng
name: Dokholyan, Nikolay V.
name: Redinbo, Matthew R.
name: Frazier, Monica L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface. While most nuclear receptor LBDs form homo- or heterodimers, the human nuclear receptor pregnane X receptor (PXR) forms a unique and essential homodimer and is proposed to assemble into a functional heterotetramer with the retinoid X receptor (RXR). How the homodimer interface, which is located 30 Å from the AF-2, would affect function at this critical surface has remained unclear. By using 20- to 30-ns molecular dynamics simulations on PXR in various oligomerization states, we observed a remarkably high degree of correlated motion in the PXR–RXR heterotetramer, most notably in the four helices that create the AF-2 domain. The function of such correlation may be to create “active-capable” receptor complexes that are ready to bind to transcriptional coactivators. Indeed, we found in additional simulations that active-capable receptor complexes involving other orphan or steroid nuclear receptors also exhibit highly correlated AF-2 domain motions. We further propose a mechanism for the transmission of long-range motions through the nuclear receptor LBD to the AF-2 surface. Taken together, our findings indicate that long-range motions within the LBD scaffold are critical to nuclear receptor function by promoting a mobile AF-2 state ready to bind coactivators.
GROMACS Stochastic Dynamics and BAOAB are equivalent configurational sampling algorithms
Creators: name: Kieninger, Stefanie
name: Keller, Bettina G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Two of the most widely used Langevin integrators for molecular dynamics simulations are the GROMACS Stochastic Dynamics (GSD) integrator and the splitting method BAOAB. In this letter, we show that the GROMACS Stochastic Dynamics integrator is equal to the less frequently used splitting method BAOA. It immediately follows that GSD and BAOAB sample the same configurations and have the same high configurational accuracy. Our numerical results indicate that GSD/BAOA has higher kinetic accuracy than BAOAB.
Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks
Creators: name: Behar, Marcelo
name: Hao, Nan
name: Elston, Timothy C.
name: Dohlman, Henrik G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The cellular response elicited by an environmental cue typically varies with the strength of the stimulus. For example, in the yeast Saccharomyces cerevisiae, the concentration of mating pheromone determines whether cells undergo vegetative growth, chemotropic growth, or mating. This implies that the signaling pathways responsible for detecting the stimulus and initiating a response must transmit quantitative information about the intensity of the signal. Our previous experimental results suggest that yeast encode pheromone concentration as the duration of the transmitted signal. Here we use mathematical modeling to analyze possible biochemical mechanisms for performing this “dose-to-duration” conversion. We demonstrate that modulation of signal duration increases the range of stimulus concentrations for which dose-dependent responses are possible; this increased dynamic range produces the counterintuitive result of “signaling beyond saturation” in which dose-dependent responses are still possible after apparent saturation of the receptors. We propose a mechanism for dose-to-duration encoding in the yeast pheromone pathway that is consistent with current experimental observations. Most previous investigations of information processing by signaling pathways have focused on amplitude encoding without considering temporal aspects of signal transduction. Here we demonstrate that dose-to-duration encoding provides cells with an alternative mechanism for processing and transmitting quantitative information about their surrounding environment. The ability of signaling pathways to convert stimulus strength into signal duration results directly from the nonlinear nature of these systems and emphasizes the importance of considering the dynamic properties of signaling pathways when characterizing their behavior. Understanding how signaling pathways encode and transmit quantitative information about the external environment will not only deepen our understanding of these systems but also provide insight into how to reestablish proper function of pathways that have become dysregulated by disease.
سنخ شناسی الگوهای فضایی پراکنده رویی در شهر- منطقه ها (مورد مطالعه: شهر- منطقه مرکزی مازندران)
Publisher: name: دانشگاه کردستان
Year: 2018

description: ساخت­ وسازهای با برنامه و بدون برنامه، منجر به گسترش شهرها و نواحی پیرامونی آنها در اراضی کشاورزی استان مازندران شده  و این اراضی را دستخوش تغییرات و یا حتی تخریب گسترده قرار داده است. هدف مقاله حاضر سنخ­ شناسی الگوهای فضایی پراکنده رویی در شهر_منطقه مرکزی مازندران( شامل شهرستان های ساری، بابل و قائمشهر)  است. روش­ شناسی پژوهش کمی بوده و داده­ های اصلی آن از طریق دو مؤلفه جمعیتی و کالبدی_فضایی به دست می ­آید. داده ­های جمعیتی از سالنامه های آماری استان مازندران و داده های کالبدی_فضایی شامل اراضی ساخته شده (براساس تصاویر لندست و نقشه 1:25000 توسعه استان مازندارن) و تراکم ساختمانی در طی سال های 1365 تا 1395 استفاده شد. سایر داده ها براساس پردازش آماری و ریاضی از داده های جمعیتی و کالبدی_فضایی با استفاده از نرم ­افزار جی.آی.اس،ای.اس.آی.آر.و مدل فرم رشد شهری به دست آمدند. سپس برای سنخ شناسی الگوهای فضایی در مقیاس کلان از برآوردگر کریجینگ و برای الگوهای فضایی در مقیاس خرد از مدل فرم رشد شهری استفاده شده است. نتایج پژوهش حاکی از این است که در مقیاس کلان، پراکنده ­رویی در سال های مطالعاتی افزایش یافته است. به رغم این که الگوی فضایی در سال 1365 به واسطه پایین بودن متغیرهای مطالعاتی، تنها در سه مرکز اصلی شهری محدوده متمرکز بوده و در اراضی پیرامون آنها به خصوص در شهرستان ساری، پراکنده رویی وجود داشته است. اما در یک روند زمانی 30 ساله همزمان با تمرکز توسعه در اراضی شهری، اراضی پیراشهری و روستایی نیز توسعه یافته و پدیده پراکنده رویی با افزایش ارزش متغیرها شدت گرفته است. از طرف دیگر، در مقیاس خرد، الگوی فضایی پراکنده ­رویی در سال های 1365 تا 1375 خطی بوده که به دلیل توسعه در پیرامون مرزهای سکونتگاه های شهری (اراضی پیراشهری) به وجود آمده است. اما در بازه 85-1375 توسعه پراکنده به الگوی میان افزا گرایش بیشتری داشته و حاکی از شکل­ گیری الگوی تلفیقی خطی_میان افزای پراکنده رویی دارد. در بازه 95-1385 نیز الگوی توسعه به صورت میان افزا شکل گرفته است. گفتنی است که در بررسی جداگانه سکونتگاه های شهری و روستایی شهر_منطقه مطالعاتی، نتایج متفاوتی در اراضی شهری مشاهده شد
Controlling Tokamak Geometry with 3D Magnetic Perturbations
Creators: name: Bird, Thomas M
name: Hegna, Chris C
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: It is shown that small externally applied magnetic perturbations can significantly alter important geometric properties of magnetic flux surfaces in tokamaks. Through 3D shaping, experimentally relevant perturbation levels are large enough to influence turbulent transport and MHD stability in the pedestal region. It is shown that the dominant pitch-resonant flux surface deformations are primarily induced by non-resonant 3D fields, particularly in the presence of significant axisymmetric shaping. The spectral content of the applied 3D field can be used to control these effects.
STRUCTURAL BEHAVIOR OF NOVEL REINFORCED BAKED CLAY SANDWICHED SLAB PANELS UNDER CONCENTRIC LOADING: A SUSTAINABLE AND COST-EFFECTIVE ALTERNATIVE
Creators: name: Khoso, Salim
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400504
subject: Construction engineering
classificationCode: 400505
subject: Construction materials
classificationCode: 400510
subject: Structural engineering
classificationCode: 400509
subject: Structural dynamics

description: The use of composite materials has been employed in many fields of engineering such as aeronautical, marine and automobile industries. This experimental investigation focuses on the strength of slab panels made of baked clay. The study consists of a layer of baked clay sandwiched between two outer layers of reinforced concrete connected by steel rods. The study was conducted on ten slab panels and was carried out mainly to measure the strength of baked clay sandwiched slabs and to study the specific weight and specific gravity of various batches made with clay and sand mixture with different ratios. The significant parameters of the study include, Mixing of clay and sand with different ratios concluding seven batches with 10%, 20%, 30%, 40%, 50% and 60% of pit sand and Compacting the sample with different loading, ranges from 0 to 6 N/mm2 with an increment of 1.0. The composite slab panels were tested as simply supported under single point load. The results obtained were quite satisfactorily with an overall increase in strength. Moreover, this approach could be a cost effective and sustainable solution for many structures and infrastructural development of any country.
Die "kleine Wirthschafft Rechnung" von Carl August Hartung
Creators: name: Talle, Andrew
Publisher: name: Bach-Jahrbuch
Year: 2018

description: Der Artikel untersucht die im Stadtarchiv Braunschweig erhaltene "Kleine Wirthschafft Rechnung", das Haushalts-Rechnungsbuch des Organisten Carl August Harthung (1723-1800), als biografische Quelle. Die Einzelbetrachtung wird eingebunden in allgemeine Überlegungen zur Möglichkeit des Informationsgewinns über Musiker-, speziell Organistenbiografien des 18. Jahrhunderts. Der nachfolgende Artikel von Peter Wollny: Carl August Harthung als Kopist und Sammler Bachscher Werke. S. 81-102 nimmt wesentlichen Bezug auf die Untersuchung. Erwähnte Artikel: Andrew Talle: Nürnberg, Darmstadt, Köthen - Neuerkenntnisse zur Bach-Überlieferung in der ersten Hälfte des 18. Jahrhunderts. BJ 2003, S. 143-172 Hans Rudolf Jung: Der Bach-Schüler Bernhard Christian Kayser als Bewerber um die Hof- und Stadtorganistenstelle in Schleiz. BJ 2005, S. 281-286
description: Bach-Jahrbuch, Bd. 97 (2011)
Where and why university students choose to use computing facilities: report on a collaborative study at an Australian and United Kingdom university
Creators: name: Burke, Liz
name: Stubbings, Ruth
name: Walton, Graham
name: Beranek, Lea Gail
Publisher: name: La Trobe
Year: 2023

description: Information Online 2007. (13th : 2007 : Sydney Convention & Exhibition Centre, Sydney, Australia)
Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers
Creators: name: Hao, Jihua
name: Dokholyan, Nikolay V.
name: Tassone, Gina
name: Serohijos, Adrian W. R.
name: Sgroi, Dennis C.
name: Basilion, James P.
name: Wang, Zuncai
name: Newton, Gail
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Cysteine-rich intestinal protein 1 (CRIP1) has been identified as a novel marker for early detection of cancers. Here we report on the use of phage display in combination with molecular modeling to identify a high-affinity ligand for CRIP1. Panning experiments using a circularized C7C phage library yielded several consensus sequences with modest binding affinities to purified CRIP1. Two sequence motifs, A1 and B5, having the highest affinities for CRIP1, were chosen for further study. With peptide structure information and the NMR structure of CRIP1, the higher-affinity A1 peptide was computationally redesigned, yielding a novel peptide, A1M, whose affinity was predicted to be much improved. Synthesis of the peptide and saturation and competitive binding studies demonstrated approximately a 10–28-fold improvement in the affinity of A1M compared to that of either A1 or B5 peptide. These techniques have broad application to the design of novel ligand peptides.
ارزیابی آسیب‏ پذیری بافت‏های مسکونی در برابر زلزله و راهکارهای کاهش آسیب پذیری (مطالعه موردی: منطقه شش شهرداری تهران)
Publisher: name: دانشگاه کردستان
Year: 2018

description: موقعیت جغرافیایی و سابقه لرزه خیزی بسیاری از شهرهای ایـران، از جمله تهران، توجه به موضوع آسیب پذیری از\nزلزله را در رشته ها و تخصص های گوناگون ملزم نموده است. برنامه ریزی شهری به دلیل ماهیت خود، این مسئله را در\nبافت های شهری مورد بررسی قرار میدهد.در همین راستا، پژوهش حاضر با بررسی و مطالعه متون و اسناد مرتبط با زلزله\nو نقش برنامه ریزی شهری در کاهش اثرات آن و همچنین برنامه ریزی بافت مسکونی و ابعاد و ویژگی های آن، به یک مدل\nعملیاتی برای سنجش میزان آسیب پذیری بافت های مسکونی منطقه شش تهران از زلزله دست یافته است. بر مبنای\nاین مدل، معیارهای لازم به منظور بررسی میزان آسیب پذیری تعیین گردید. براساس معیارهای یادشده، منطقه شش\nتهران به تفکیک محله های مسکونی مورد بررسی قرار گرفت. سنجش میزان آسیب پذیری محلات مسکونی مورد بررسی، بر\nمبنای مقدار استخراج شده برای معیارهای ارزیابی و با استفاده از روش ای.اچ.پی.صورت گرفت. در نهایت، اهداف، راهبردها و\nسیاست های لازم برای کاهش میزان آسیب پذیری با توجه به ضریب اهمیت های به دست آمده با استفاده از همین روش،\nبه تفکیک محلات 17گانه مورد بررسی تدوین گردید. براساس نتایج به دست آمده از بررسی ها و محاسبات انجام شده\nدر پژوهش حاضر، اتخاذ راهکارهایی در پنج دسته شکل کلی بافت مسکونی (قطعه بندی، توزیع کاربریها، همجواری ها\nو،...) فضاهای سبز و باز عمومی، شبکه دسترسی، تراکم جمعیت و کنترل و نظارت بر ساخت وساز میتواند در ارتقای ایمنی\nمحله های منطقه شش در برابر زلزله مؤثر واقع شود
Multi-Finger Grasping Like Humans
Creators: name: Du, Yuming
name: Weinzaepfel, Philippe
name: Lepetit, Vincent
name: Brégier, Romain
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Robots with multi-fingered grippers could perform advanced manipulation tasks for us if we were able to properly specify to them what to do. In this study, we take a step in that direction by making a robot grasp an object like a grasping demonstration performed by a human. We propose a novel optimization-based approach for transferring human grasp demonstrations to any multi-fingered grippers, which produces robotic grasps that mimic the human hand orientation and the contact area with the object, while alleviating interpenetration. Extensive experiments with the Allegro and BarrettHand grippers show that our method leads to grasps more similar to the human demonstration than existing approaches, without requiring any gripper-specific tuning. We confirm these findings through a user study and validate the applicability of our approach on a real robot.
description: presented at IROS 2022 conference
SOMOS: The Samsung Open MOS Dataset for the Evaluation of Neural Text-to-Speech Synthesis
Creators: name: Maniati, Georgia
name: Vioni, Alexandra
name: Ellinas, Nikolaos
name: Nikitaras, Karolos
name: Klapsas, Konstantinos
name: Sung, June Sig
name: Jho, Gunu
name: Chalamandaris, Aimilios
name: Tsiakoulis, Pirros
Publisher: name: arXiv
Year: 2022
Subjects: subject: Sound (cs.SD)
subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this work, we present the SOMOS dataset, the first large-scale mean opinion scores (MOS) dataset consisting of solely neural text-to-speech (TTS) samples. It can be employed to train automatic MOS prediction systems focused on the assessment of modern synthesizers, and can stimulate advancements in acoustic model evaluation. It consists of 20K synthetic utterances of the LJ Speech voice, a public domain speech dataset which is a common benchmark for building neural acoustic models and vocoders. Utterances are generated from 200 TTS systems including vanilla neural acoustic models as well as models which allow prosodic variations. An LPCNet vocoder is used for all systems, so that the samples' variation depends only on the acoustic models. The synthesized utterances provide balanced and adequate domain and length coverage. We collect MOS naturalness evaluations on 3 English Amazon Mechanical Turk locales and share practices leading to reliable crowdsourced annotations for this task. We provide baseline results of state-of-the-art MOS prediction models on the SOMOS dataset and show the limitations that such models face when assigned to evaluate TTS utterances.
description: Accepted to INTERSPEECH 2022
Path of the current flow at the metal contacts of graphene field-effect transistors with distorted transfer characteristics
Creators: name: Nouchi, Ryo
name: Tanigaki, Katsumi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Graphene field-effect transistors with source/drain contacts made of metals that can be easily oxidized such as ferromagnetic metals often display a double dip structure in the transfer characteristics because of charge density depinning at the contacts. Generally, transfer characteristics of field-effect transistors show no dependence on the length of the source/drain contacts because charge carrier injection occurs mainly at the edges of the contact. However, the shape of the transfer characteristics of devices fabricated using Ni contacts is found to be dependent on the length of the contact. This peculiar behavior was attributed to charge carrier injection from near the center of the contacts. This is because of oxygen diffusion and the resultant formation of an interfacial oxide layer of non-uniform thickness. The observed contact length dependent transfer characteristics were reproduced using a model calculation that includes charge carrier injection from the center of the electrode and subsequent charge transport underneath the metal contact.
Carl August Hartung als Kopist und Sammler Bachscher Werke
Creators: name: Wollny, Peter
Publisher: name: Bach-Jahrbuch
Year: 2018

description: Unter Bezugnahme auf den voranstehenden Artikel von Andrew Talle "'Die kleine Wirthschafft Rechnung' von Carl August Harthung" wird die Bedeutung Harthungs für den Musikalienhandel seienr Zeit beleuchtet. Zunächst wird Harthung auf Grundlage der von Talle ausgewerteten Quelle als Schreiber zweier thematischer Verzeichnisse von Werken Bachs identifiziert. Daran knüpfen weiterführende Überlegungen zur Verbreitung bestimmter Bachscher Werke im 18. Jh. an. Weiterhin wird aufgrund der Notenschrift Harthungs ein bisher anonymer Bach-Kopist mit ihm Gleichgesetzt. Ein Anhang bietet einen Katalog aller Bach-Abschriften von der Hand Harthungs. Erwähnte Artikel: Hans Löffler: Die Schüler Joh. Seb. Bach. BJ 1953, S. 5-28 Klaus Hofmann: Forkel und die Köthener Trauermusik Johann Sebastian Bach. BJ 1983, S. 115-117 Hans-Joachim Schulze: Bach-Überlieferung in Hamburg: Der Quellenbesitz von Christian Friedrich Gottlieb Schwencke (1767-1822). BJ 1993, S. 69-79 Christoph Wolff: Nachwort zu Christoph Henzel: "...ein Großes Orgelkonzert von dem alten Sebastian Bach". Zu einem Konzertprogramm Johann Wilhelm Häßlers. BJ 1993, S. 231-237 (S. 236-237) Peter Wollny: Johann Christoph Friedrich Bach und die Teilung des väterlichen Erbes. BJ 2001, S. 55-70 Michael Maul, Peter Wollny: Quellenkundliches zu Bach-Aufführungen in Köthen, Ronneburg und Leipzig zwischen 1720 und 1760. BJ 2003, S. 97-142 Andrew Talle: Nürnberg, Darmstadt, Köthen - Neuerkenntnisse zur Bach-Überlieferung in der ersten Hälfte des 18. Jahrhunderts. BJ 2003, S. 143-172 Hans-Joachim Schulze: Eine verschollene Choralpartita Johann Sebastian Bachs? BJ 2003, S. 229-232 Pieter Dirksen: Zur Echtheit der Johann Christoph Bach (1642-1703) zugeschriebenen Clavierwerke. BJ 2010, S. 217-248 Vergleiche auch: Andrew Talle: "Die kleine Wirthschafft Rechnung" von Carl August Harthung. BJ 2011, S. 51-80
description: Bach-Jahrbuch, Bd. 97 (2011)
A Structural Model of the Pore-Forming Region of the Skeletal Muscle Ryanodine Receptor (RyR1)
Creators: name: Meissner, Gerhard
name: Serohijos, Adrian W. R.
name: Xu, Le
name: Ramachandran, Srinivas
name: Dokholyan, Nikolay V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Ryanodine receptors (RyRs) are ion channels that regulate muscle contraction by releasing calcium ions from intracellular stores into the cytoplasm. Mutations in skeletal muscle RyR (RyR1) give rise to congenital diseases such as central core disease. The absence of high-resolution structures of RyR1 has limited our understanding of channel function and disease mechanisms at the molecular level. Here, we report a structural model of the pore-forming region of RyR1. Molecular dynamics simulations show high ion binding to putative pore residues D4899, E4900, D4938, and D4945, which are experimentally known to be critical for channel conductance and selectivity. We also observe preferential localization of Ca2+ over K+ in the selectivity filter of RyR1. Simulations of RyR1-D4899Q mutant show a loss of preference to Ca2+ in the selectivity filter as seen experimentally. Electrophysiological experiments on a central core disease mutant, RyR1-G4898R, show constitutively open channels that conduct K+ but not Ca2+. Our simulations with G4898R likewise show a decrease in the preference of Ca2+ over K+ in the selectivity filter. Together, the computational and experimental results shed light on ion conductance and selectivity of RyR1 at an atomistic level.
معیارهای موثر بر شکل گیری تصویر ذهنی زنان از فضای شهری مطلوب (مطالعه موردی: شهر تهران)
Publisher: name: دانشگاه کردستان
Year: 2018

description: رابطه فرد_محیط در سطوح فردی مرتبط با احساس، ادراک، ارزشها و تجربیات ذهنی و... و در سطوح اجتماعی مانند\nگروه های مختلف اجتماع و یا گروه هایی که به لحاظ سن وجنس مشابهند، شکل گرفته است؛ بنابراین ویژگی های هر\nگروه و قشر باید در هر سطح مورد بررسی قرار گیرد. از طرفی جنسیت مانند عواملی همچون محل سکونت، سن، شرایط\nاجتماعی_اقتصادی، قومیت، سطح درآمد بر ادراک و شناخت محیط تأثیر میگذارد. بنابراین پرداختن به مفاهیم ذهنی\nفرد و شکل گیری تصویر ذهنی از محیط و تأثیر آن در رفتار و همچنین قضاوت نسبت به انتخاب مکان مطلوب، برای زنان\nضرورت می یابد. این مقاله با بررسی عوامل تأثیرگذار در شکل گیری تصویر ذهنی زنان، به منظور امکان به وجود آمدن\nمحیطی مطلوب از دید این گروه اجتماعی، ترجیحات فضایی آنان را ارزیابی نموده است. آنچه اهمیت دارد، شناسایی\nو ارزیابی معیارهای اصلی انتخاب زنان در تعیین مکان مطلوب با توجه به معانی بر گرفته از تصاویر ذهنی ارزیابانه است\nهدف این پژوهش، بازیابی معیارهای مؤثر بر مطلوبیت مکان از دید زنان و ارزیابی تصویر ذهنی شکل گرفته آنها از فضاهای\nعمومی شهر تهران است\nرویکرد تفسیر گرایانه پدیدارشناسی برای توصیف معانی ضمنی و احساسات و عواطف بازنمایی شده از تصویر ذهنی زنان در\nتجربه فضاهای شهری مطلوب شهر تهران انجام گرفته و ماهیتی توسعه ای دارد. به این منظور  15مصاحبه عمیق به صورت\nنمونه گیری هدفمند صورت گرفت. مصاحبه ها ضبط شده و داده هـای به دست آمده از آن به صورت جداول مکتوب\nشده و با آنالیز تکرار پذیری تجزیه و تحلیل گردید. نتایج گویای آن است که انتخاب مکانی که از دریچه تصویر ذهنی\nزنان مطلوب ارزیابی شده است، به معانی مشترکی مرتبط با مفاهیم آزادی، عدالت، امنیت، منزلت مکان، دارای وجهه\nاجتماعی_فرهنگی، هویت تاریخی، زیبایی، شیک و پر از جزئیات، آرام و دنج، دارای حریم در عین وسعت، سرسبزی، روحیه\nشاد و سلامت تمایل دارد
Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR
Creators: name: Krasowski, Matthew D.
name: Kortagere, Sandhya
name: Ekins, Sean
name: Iyer, Manisha
name: Redinbo, Matthew R.
name: Reschly, Erica J.
name: Lill, Markus A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including steroid hormones. Activation of PXR has the potential to initiate adverse effects, altering drug pharmacokinetics or perturbing physiological processes. Reliable computational prediction of PXR agonists would be valuable for pharmaceutical and toxicological research. There has been limited success with structure-based modeling approaches to predict human PXR activators. Slightly better success has been achieved with ligand-based modeling methods including quantitative structure-activity relationship (QSAR) analysis, pharmacophore modeling and machine learning. In this study, we present a comprehensive analysis focused on prediction of 115 steroids for ligand binding activity towards human PXR. Six crystal structures were used as templates for docking and ligand-based modeling approaches (two-, three-, four- and five-dimensional analyses). The best success at external prediction was achieved with 5D-QSAR. Bayesian models with FCFP_6 descriptors were validated after leaving a large percentage of the dataset out and using an external test set. Docking of ligands to the PXR structure co-crystallized with hyperforin had the best statistics for this method. Sulfated steroids (which are activators) were consistently predicted as non-activators while, poorly predicted steroids were docked in a reverse mode compared to 5α-androstan-3β-ol. Modeling of human PXR represents a complex challenge by virtue of the large, flexible ligand-binding cavity. This study emphasizes this aspect, illustrating modest success using the largest quantitative data set to date and multiple modeling approaches.
Evolution of a Signaling Nexus Constrained by Protein Interfaces and Conformational States
Creators: name: Jones, Alan M.
name: Jones, Corbin D.
name: Temple, Brenda R. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Heterotrimeric G proteins act as the physical nexus between numerous receptors that respond to extracellular signals and proteins that drive the cytoplasmic response. The Gα subunit of the G protein, in particular, is highly constrained due to its many interactions with proteins that control or react to its conformational state. Various organisms contain differing sets of Gα-interacting proteins, clearly indicating that shifts in sequence and associated Gα functionality were acquired over time. These numerous interactions constrained much of Gα evolution; yet Gα has diversified, through poorly understood processes, into several functionally specialized classes, each with a unique set of interacting proteins. Applying a synthetic sequence-based approach to mammalian Gα subunits, we established a set of seventy-five evolutionarily important class-distinctive residues, sites where a single Gα class is differentiated from the three other classes. We tested the hypothesis that shifts at these sites are important for class-specific functionality. Importantly, we mapped known and well-studied class-specific functionalities from all four mammalian classes to sixteen of our class-distinctive sites, validating the hypothesis. Our results show how unique functionality can evolve through the recruitment of residues that were ancestrally functional. We also studied acquisition of functionalities by following these evolutionarily important sites in non-mammalian organisms. Our results suggest that many class-distinctive sites were established early on in eukaryotic diversification and were critical for the establishment of new Gα classes, whereas others arose in punctuated bursts throughout metazoan evolution. These Gα class-distinctive residues are rational targets for future structural and functional studies.
Multiqubit state learning with entangling quantum generative adversarial networks
Creators: name: Rasmussen, S. E.
name: Zinner, N. T.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The increasing success of classical generative adversarial networks (GANs) has inspired several quantum versions of GANs. Fully quantum mechanical applications of such quantum GANs have been limited to one- and two-qubit systems. In this paper, we investigate the entangling quantum GAN (EQ-GAN) for multiqubit learning. We show that the EQ-GAN can learn a circuit more efficiently compared with a SWAP test. We also consider the EQ-GAN for learning eigenstates that are variational quantum eigensolver (VQE)-approximated, and find that it generates excellent overlap matrix elements when learning VQE states of small molecules. However, this does not directly translate into a good estimate of the energy due to a lack of phase estimation. Finally, we consider random state learning with the EQ-GAN for up to six qubits, using different two-qubit gates, and show that it is capable of learning completely random quantum states, something which could be useful in quantum state loading.
description: 8 pages, 8 figures, 1 table
Forschungslandschaft im Blickfeld: Das Personen-Gesamtregister zu den Kritischen Berichten der Neuen Bach-Ausgabe - Materialien, Probleme, Aufgaben
Creators: name: Schulze, Hans-Joachim
Publisher: name: Bach-Jahrbuch
Year: 2018

description: Der Artikel liefert eine Zusammenstellung von Ergänzungen und Berichtigungen zum im 2010 veröffentlichten „Gesamtregister zur NBA“ (vorgelegt von Frauke Heinze und Uwe Wolf, Kassel etc. 2010) enthaltenen Namenregister zu den Kritischen Berichten. In den drei Kategorien I - Obskure und periphere Zeitgenossen J. S. Bachs; II - Besitzer und Vermittler von Originalhandschriften, III - Anmerkungen zu einigen Musikforschern und anderen Wissenschaftlern des 20. Jh. werden weitergehende Informationen zu einer Auswahl der dort angeführten Personen gegeben. Erwähnte Artikel: Heinrich Miesner: Aus der Umwelt Philipp Emanuel Bachs. BJ 1937, S. 132-143 Ulrich Leisinger, Peter Wollny: "Altes Zeug von mir". Carl Philipp Emanuel Bachs kompositorisches Schaffen vor 1740. BJ 1993, S. 127-204 Michael Maul, Peter Wollny: Quellenkundliches zu Bach-Aufführungen in Köthen, Ronneburg und Leipzig zwischen 1720 und 1760. BJ 2003, S. 97-142 Tadashi Isoyama: Wiederaufgefundene Originalstimmen zur Hochzeitskantate "Vergnügte Pleißenstadt" BWV 216. BJ 2004, S. 199-208
description: Bach-Jahrbuch, Bd. 98 (2012)
Lossy compression of matrices by black-box optimisation of mixed integer nonlinear programming
Creators: name: Kadowaki, Tadashi
name: Ambai, Mitsuru
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Optimization and Control (math.OC)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In edge computing, suppressing data size is a challenge for machine learning models that perform complex tasks such as autonomous driving, in which computational resources (speed, memory size and power) are limited. Efficient lossy compression of matrix data has been introduced by decomposing it into the product of an integer and real matrices. However, its optimisation is difficult as it requires simultaneous optimisation of an integer and real variables. In this paper, we improve this optimisation by utilising recently developed black-box optimisation (BBO) algorithms with an Ising solver for integer variables. In addition, the algorithm can be used to solve mixed-integer programming problems that are linear and non-linear in terms of real and integer variables, respectively. The differences between the choice of Ising solvers (simulated annealing, quantum annealing and simulated quenching) and the strategies of the BBO algorithms (BOCS, FMQA and their variations) are discussed for further development of the BBO techniques.
description: 11 pages, 7 figures
Model Review: A PROMISEing Opportunity
Creators: name: Menzies, Tim
Publisher: name: arXiv
Year: 2023
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: To make models more understandable and correctable, I propose that the PROMISE community pivots to the problem of model review. Over the years, there have been many reports that very simple models can perform exceptionally well. Yet, where are the researchers asking "say, does that mean that we could make software analytics simpler and more comprehensible?" This is an important question, since humans often have difficulty accurately assessing complex models (leading to unreliable and sometimes dangerous results). Prior PROMISE results have shown that data mining can effectively summarizing large models/ data sets into simpler and smaller ones. Therefore, the PROMISE community has the skills and experience needed to redefine, simplify, and improve the relationship between humans and AI.
description: 5 pages, 1 figure