cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
First total synthesis of a novel amide alkaloid derived from Aconitum taipeicum and its anticancer activity
Creators: name: Zhang, Xinxin
name: Li, Dandan
name: Xue, Xuanji
name: Zhang, Yan
name: Zhang, Jie
name: Huang, Chen
name: Guo, Zengjun
name: Tadesse, Nigatu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: A concise total synthesis of a naturally occurring 3-isopropyl-tetrahydropyrrolo[1, 2-a]pyrimidine-2, 4(1H, 3H)-dione (ITPD) isolated from Aconitum taipeicum with a three-step approach was depicted in this study for the first time. Two key intermediates, diethyl isopropylmalonate (2) and pyrrolidin-2-amine (3), being synthsesised separately from initial diethyl malonate (4) and 3, 4-dihydro-2H-pyrrol-5-amine (5), were utilised to obtain the compound entitled ITPD. ITPD showed a promising anticancer activity in vitro on SMMC-7721 cell lines. Flow cytometry and cell cycle analysis revealed that ITPD could induce apoptosis and cell cycle arrest in S phase. The occurrence of apoptosis possibly attributed to the mechanism that ITPD could mediate the mitochondrial pathway through activating caspase-3/9 and increasing the ratio of Bax/Bcl-2 to finally trigger cell apoptosis and DNA damage. Collectively, the possibility to produce sufficient quantity of synthetic ITPD provided the base for further bio-evaluation in vivo and in vitro. The bioactive assay suggested that it may be a potential candidate for further chemical optimisation and use in cancer therapy.
Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1
Creators: name: Kreyling, Wolfgang G.
name: Holzwarth, Uwe
name: Haberl, Nadine
name: Kozempel, Ján
name: Hirn, Stephanie
name: Wenk, Alexander
name: Schleh, Carsten
name: Schäffler, Martin
name: Lipka, Jens
name: Semmler-Behnke, Manuela
name: Gibson, Neil
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Submicrometer TiO2 particles, including nanoparticulate fractions, are used in an increasing variety of consumer products, as food additives and also drug delivery applications are envisaged. Beyond exposure of occupational groups, this entails an exposure risk to the public. However, nanoparticle translocation from the organ of intake and potential accumulation in secondary organs are poorly understood and in many investigations excessive doses are applied. The present study investigates the biokinetics and clearance of a low single dose (typically 40–400 μg/kg BW) of 48V-radiolabeled, pure TiO2 anatase nanoparticles ([48V]TiO2NP) with a median aggregate/agglomerate size of 70 nm in aqueous suspension after intravenous (IV) injection into female Wistar rats. Biokinetics and clearance were followed from one-hour to 4-weeks. The use of radiolabeled nanoparticles allowed a quantitative [48V]TiO2NP balancing of all organs, tissues, carcass and excretions of each rat without having to account for chemical background levels possibly caused by dietary or environmental titanium exposure. Highest [48V]TiO2NP accumulations were found in liver (95.5%ID after one day), followed by spleen (2.5%), carcass (1%), skeleton (0.7%) and blood (0.4%). Detectable nanoparticle levels were found in all other organs. The [48V]TiO2NP content in blood decreased rapidly after 24 h while the distribution in other organs and tissues remained rather constant until day-28. The present biokinetics study is part 1 of a series of studies comparing biokinetics after three classical routes of intake (IV injection (part 1), ingestion (part 2), intratracheal instillation (part 3)) under identical laboratory conditions, in order to test the common hypothesis that IV-injection is a suitable predictor for the biokinetics fate of nanoparticles administered by different routes. This hypothesis is disproved by this series of studies.
H2O2 as green and environmentally benign reagent for the oxidation of TMS ethers, THP ethers, and alcohols in the presence of {[K.18-Crown-6]Br3}n
Creators: name: Rasouli, Mohsen
name: Zolfigol, Mohammad Ali
name: Moslemin, Mohammad Hossein
name: Gholamabbas Chehardoli
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In the presence of {[K.18-Crown-6]Br3}n, a unique tribromide reagent, trimethylsilyl (TMS) ethers, tetrahydropyranyl (THP) ethers, and alcohols were oxidized to their corresponding aldehydes and ketones in H2O2. One-pot deprotection and oxidation of TMS ethers/THP ethers were performed directly and the conversion was complete. Avoiding the isolation of the corresponding alcohol as an intermediate step, the direct transformation of such substrates to carbonyls is the main aim of this work. {[K.18-Crown-6]Br3}n regeneration was performed via the addition of Br2 to the residue of the reaction and recrystallization in acetonitrile.
Involvement of the cytokine–IDO1–AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation
Creators: name: Ho, Chia-Chi
name: Lee, Hui-Ling
name: Chen, Chao-Yu
name: Yueh-Hsia Luo
name: Ming-Hsien Tsai
name: Hui-Ti Tsai
name: Pinpin Lin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: Zinc oxide nanoparticles (ZnONPs) are widely used in our daily life, such as in sunscreens and electronic nanodevices. However, pulmonary exposure to ZnONPs causes acute pulmonary inflammation, which is considered as an initial event for various respiratory diseases. Thus, elucidation of the underlying cellular mechanisms of ZnONPs can help us in predicting their potential effects in respiratory diseases. In this study, we observed that ZnONPs increased proinflammatory cytokines, accompanied with an increased expression of aryl hydrocarbon receptor (AhR) and its downstream target cytochrome P450 1A1 (CYP1A1) in macrophages in vitro and in mouse lung epithelia in vivo. Moreover, zinc nitrate, but not silica or titanium dioxide nanoparticles (NPs), had similar effects on macrophages, indicating that the zinc element or ion released from ZnONPs is likely responsible for the activation of the AhR pathway. Cotreatment with an AhR antagonist or AhR knockout reduced ZnONPs-induced cytokine secretion in macrophages or mice, respectively. Furthermore, kynurenine (KYN), an endogenous AhR agonist and a tryptophan metabolite catalyzed by indoleamine 2,3-dioxygenase (IDO), was increased in the serums of mice that aspirated ZnONPs. Consistently, ZnONPs increased IDO1 expression in lung cells in vitro and in vivo. Finally, AhR knockout reduced ZnONPs-induced pulmonary inflammation, cytokine secretion and KYN production in mice, suggesting that AhR activation is involved in ZnONPs-induced cytokine secretion and pulmonary inflammation. In summary, we demonstrated that the pulmonary exposure of ZnONPs stimulated the cytokine–IDO1–AhR loop in the lungs, which has been implied to play roles in immune dysfunctions.
A cross-sectional study of changes in markers of immunological effects and lung health due to exposure to multi-walled carbon nanotubes
Creators: name: Vlaanderen, Jelle
name: Anjoeka Pronk
name: Rothman, Nathaniel
name: Hildesheim, Allan
name: Silverman, Debra
name: H. Dean Hosgood
name: Spaan, Suzanne
name: Kuijpers, Eelco
name: Lode Godderis
name: Hoet, Peter
name: Lan, Qing
name: Vermeulen, Roel
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Background: Multi-wall carbon nanotubes (MWCNTs) are manufactured nanomaterials to which workers and the general population will be increasingly exposed in coming years. Little is known about potential human health effects of exposure to MWCNTs, but effects on the lung and the immune system have been reported in animal and mechanistic studies. Objectives: We conducted a cross-sectional study to assess the association between occupational exposure to MWCNTs and effects on lung health and the immune system. Methods: We assessed 51 immune markers and three pneumoproteins in serum, complete blood cell counts (CBC), fractional exhaled nitric oxide (FENO), and lung function among 22 workers of a MWCNT producing facility and 39 age- and gender-matched, unexposed controls. Measurements were repeated four months later among 16 workers also included in the first phase of the study. Regression analyses were adjusted for potentially confounding parameters age, body mass index, smoking, and sex, and we explored potential confounding by other factors in sensitivity analyses. Results: We observed significant upward trends for immune markers C-C motif ligand 20 (p = .005), basic fibroblast growth factor (p = .05), and soluble IL-1 receptor II (p = .0004) with increasing exposure to MWCNT. These effects were replicated in the second phase of the study and were robust to sensitivity analyses. We also observed differences in FENO and several CBC parameters between exposed and non-exposed, but no difference in lung function or the pneumoproteins. Conclusions: We observed indications of early effects of occupational exposure to MWCNTs on lung health and the immune system.
Solvent-free organic salt media mono symmetrical aza-Michael: synthesis of new N-mono substituted phthalhydrazide derivatives
Creators: name: Soltanzadeh, Zahra
name: Gholamhassan Imanzadeh
name: Noroozi-Pesyan, Nader
name: Şahin, Ertan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: In this paper, C–N bond formation between 2,3-dihydrophthalazine-1(4H),4-dione (phthalhydrazide) and α,β-unsaturated esters was investigated and a new series of phthalazine derivatives was synthesized using an efficient and simple method under solvent-free conditions. An aza-Michael addition of phthalhydrazide to both acrylic and fumaric esters led to N-mono-substituted phthalhydrazides (as mono-Michael adduct) in the presence of tetrabutylammonium bromide as a high polar media, and 1,4-diaza-bicyclo[2,2,2]octane as an available organic base. In this reaction, the N1,N2-bis-Michael adduct was not observed at all. Also, reactions were performed at 90°C and yields of products were good to excellent.
Flexible Expectile Regression in Reproducing Kernel Hilbert Spaces
Creators: name: Yang, Yi
name: Zhang, Teng
name: Zou, Hui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy

description: Expectile, first introduced by Newey and Powell in 1987 in the econometrics literature, has recently become increasingly popular in risk management and capital allocation for financial institutions due to its desirable properties such as coherence and elicitability. The current standard tool for expectile regression analysis is the multiple linear expectile regression proposed by Newey and Powell in 1987. The growing applications of expectile regression motivate us to develop a much more flexible nonparametric multiple expectile regression in a reproducing kernel Hilbert space. The resulting estimator is called KERE, which has multiple advantages over the classical multiple linear expectile regression by incorporating nonlinearity, nonadditivity, and complex interactions in the final estimator. The kernel learning theory of KERE is established. We develop an efficient algorithm inspired by majorization-minimization principle for solving the entire solution path of KERE. It is shown that the algorithm converges at least at a linear rate. Extensive simulations are conducted to show the very competitive finite sample performance of KERE. We further demonstrate the application of KERE by using personal computer price data. Supplementary materials for this article are available online.
Sur la Resolution des Equations de Troisime et Quatrieme Degre
Creators: name: Cauli, Alessandra
Publisher: name: arXiv
Year: 2023
Subjects: subject: History and Overview (math.HO)
subject: FOS: Mathematics

description: The paper deals with the resolution of third and fourth degree equations by means of radicals. It is a survey of some historical details about this fundamental problem. Moreover, it explains practical methods for the resolution of third and fourth degree equation through the algebraic side and we introduce some results about the equations of greater degree. Mathematicians and complex numbers and the results of rules of calculations as well as having completed the theory of equations model Mathematics in different historical and chronological contexts at several levels of research. The subject would join a reference auditorium for authors, teachers and students at a time when the context of collocation favors algebraic equations and radical solutions.
description: in French language, a translation of: On the Resolution of Third and Fourth Degree Equations
Supplementary Material for: Interaction of Soluble CXC Ligand 16 and Cardiac Injury Markers in Hemodialysis Patients
Creators: name: W., Liu
name: Wang, Lulu
name: Y., Wei
name: X., Li
name: C., Gao
name: J., Zhou
name: Wang, Liang
name: Z., Sun
name: H., Chu
name: Y., Bai
name: J., Yang
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Recent data suggest that there is a
pathogenic role for CXC ligand 16 (CXCL16) in cardiovascular diseases.
Little is known about circulating CXCL16 in patients with kidney
dysfunction. We explored the relationships of plasma CXCL16 with cardiac
 injury markers in a group of dialysis patients. Methods:
Plasma CXCL16 and C-reactive protein (CRP) were measured in 366 patients
 who were on maintenance hemodialysis. Cardiac injury was evaluated via
measurements of the circulating B-type natriuretic peptide (BNP),
N-terminal prohormone of brain natriuretic peptide (NT proBNP), Troponin
 I (TnI), and Troponin T (TnT). Sixty healthy subjects who were
frequency matched with the patients on the basis of age and gender were
recruited as healthy controls. Results: The mean age of
the patients was 52.5 ± 12.1 years and 56.3% were male. Circulating
CXCL16 was significantly higher in the patients than in the controls
(patients vs. controls: 477.3 (367.0-647.1) pg/mL vs. 229.5
(203.8-254.5) pg/mL; p < 0.001). The log-transformed (log-)
CXCL16 level was correlated with all 4 cardiac markers (log-BNP,
log-NTproBNP, log-TnI, and log-TnT) with high levels of significance
(all p < 0.001), even after extensive controls for the
covariates. In contrast, CRP was correlated only with BNP (marginally)
and NT proBNP and was not correlated with troponins. Conclusion:
 We showed, for the first time, highly significant relationships of
circulating CXCL16 level with cardiac injury markers in dialysis
patients. Our data suggest that circulating CXCL16 is possibly involved
in the pathological process of cardiovascular damage in dialysis
patients and may serve as a therapeutic target for cardiac protection in
 these patients.
Further development of SDSPT2 for strongly correlated electrons
Creators: name: Yibo Lei
name: Wenjian Liu
name: Hoffmann, Mark R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: The static-dynamic-static multi-state multi-reference second-order perturbation theory (SDS-MS-MRPT2 or SDSPT2 in short), which employs a multi-partitioned (state-dependent) Møller–Plesset-like diagonal operator for the zeroth-order Hamiltonian and individual configuration state functions for the perturbers, is reconsidered by making use of the state-universal Dyall Hamiltonian for the zeroth-order Hamiltonian and the union of spin-adapted, internally contracted basis functions generated from all the reference functions for the perturbers. The graphical unitary group approach along with particle–hole correspondence is employed in the evaluation of Hamiltonian matrix elements. This particular variant of SDSPT2 can also be regarded as an extension of the spin-adapted, partially contracted variant of NEVPT2 (n-electron valence state second-order perturbation theory). The performance of SDSPT2 is examined by taking C2, LiF, and Fe(C5H5)2 as examples. The results show that the low-lying states of the systems can be obtained very accurately.
Psychedelic-assisted therapy for palliative care within a home treatment setting : a case report
Creators: name: Seragnoli, Federico
name: Martignoni, Geo
name: Martignoni, Entela
name: Bachmann, Silke
name: Rabitti, Elisa
name: Cavuto, Silvio
name: Dubus, Zoe
name: Penzenstadler, Louise
name: Thorens, Gabriel
name: Billieux, Joël
name: Zullino, Daniele
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 150

description: This case study describes the feasibility and safety of psychedelic-assisted therapy (PAT) as a home-based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well. This case supports the feasibility and safety of PAT for patients with life-threatening conditions in a home setting. Psychedelic-assisted therapy (PAT), as it is practiced today, merges traditional psychotherapeutic techniques with the use of psychedelics such as LSD, psilocybin, or MDMA with the aim of unlocking deeper insights in patients and treating mental conditions that are resistant to other forms of therapy. The present case study describes the safety of PAT as a home-based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well and was asked to report on measures of anxiety, depression, and distress related to his somatic condition. The observations provided by this clinical case report align with previous findings, suggesting that PAT can be safely applied to potentially provide relief from existential distress in patients with life-threatening conditions. As this is a single-case study, generalizations should be made cautiously. Moreover, placebo effects, expectancy effects, and the natural course of the disease may influence outcomes. Future research should consider controlled trials to ascertain the efficacy and safety of such interventions in diverse settings.
One pair of new cyclopentaisochromenone enantiomer from Alternaria sp. TNXY-P-1 and their cytotoxic activity
Creators: name: Lu, Xiao-Jie
name: Chen, Shao-Fei
name: Xu, Xiang-Wei
name: Zhao, Dan
name: Wang, Hai-Feng
name: Bai, Jiao
name: Hua, Hui-Ming
name: Chen, Gang
name: Pei, Yue-Hu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Plant Biology

description: One pair of new cyclopentaisochromenone derivatives, (+)-(S)-6-hydroxy-1,8-dimethoxy-3a-methyl-3,3a-dihydrocyclopenta[c]isochromene-2,5-dione (1a) and (-)-(R)-6-hydroxy-1,8-dimethoxy-3a-methyl-3,3a-dihydrocyclopenta[c]isochromene-2,5-dione (1b), together with seven known analog 2‒8, were isolated from a rice solid culture of the endophytic fungus Alternaria sp. TNXY-P-1, obtained from fresh leaf of Arisaema heterophyllum. Their structures were elucidated on the basis of detailed 1D, 2D NMR, and HRESIMS analysis. Among them, compounds 1a and 1b were enantiomers separated from 1 by chiral HPLC. The absolute configurations of 1a and 1b were assigned by quantum chemical calculations of the electronic circular dichroic spectra. All isolated compounds were evaluated for cytotoxic activities. Interestingly, enantiomers (+)-1a and (−)-1b showed distinct selective antitumor activities against HL-60 cell lines with IC50 values of >200, 75.3 μM, respectively.
Visual stimuli in intervention approaches for pre-schoolers diagnosed with phonological delay
Creators: name: Pedro, Cassandra Ferreira
name: Lousada, Marisa
name: Hall, Andreia
name: Jesus, Luis M. T.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: The aim of this study was to develop and content validate specific speech and language intervention picture cards: The Letter-Sound (L&S) cards. The present study was also focused on assessing the influence of these cards on letter-sound correspondences and speech sound production. An expert panel of six speech and language therapists analysed and discussed the L&S cards based on several criteria previously established. A Speech and Language Therapist carried out a 6-week therapeutic intervention with a group of seven Portuguese phonologically delayed pre-schoolers aged 5;3 to 6;5. The modified Bland–Altman method revealed good agreement among evaluators, that is the majority of the values was between the agreement limits. Additional outcome measures were collected before and after the therapeutic intervention process. Results indicate that the L&S cards facilitate the acquisition of letter-sound correspondences. Regarding speech sound production, some improvements were also observed at word level. The L&S cards are therefore likely to give phonetic cues, which are crucial for the correct production of therapeutic targets. These visual cues seemed to have helped children with phonological delay develop the above-mentioned skills.
Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment
Creators: name: Wu, Kaiming
name: Zhao, Zhenxian
name: Liu, Kuanzhi
name: Zhang, Jian
name: Li, Guanghua
name: Wang, Liang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3+CD8+T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.
EEG Decoding for Datasets with Heterogenous Electrode Configurations using Transfer Learning Graph Neural Networks
Creators: name: Han, Jinpei
name: Wei, Xiaoxi
name: Faisal, A. Aldo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Signal Processing (eess.SP)
subject: Machine Learning (cs.LG)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Brain-Machine Interfacing (BMI) has greatly benefited from adopting machine learning methods for feature learning that require extensive data for training, which are often unavailable from a single dataset. Yet, it is difficult to combine data across labs or even data within the same lab collected over the years due to the variation in recording equipment and electrode layouts resulting in shifts in data distribution, changes in data dimensionality, and altered identity of data dimensions. Our objective is to overcome this limitation and learn from many different and diverse datasets across labs with different experimental protocols. To tackle the domain adaptation problem, we developed a novel machine learning framework combining graph neural networks (GNNs) and transfer learning methodologies for non-invasive Motor Imagery (MI) EEG decoding, as an example of BMI. Empirically, we focus on the challenges of learning from EEG data with different electrode layouts and varying numbers of electrodes. We utilise three MI EEG databases collected using very different numbers of EEG sensors (from 22 channels to 64) and layouts (from custom layouts to 10-20). Our model achieved the highest accuracy with lower standard deviations on the testing datasets. This indicates that the GNN-based transfer learning framework can effectively aggregate knowledge from multiple datasets with different electrode layouts, leading to improved generalization in subject-independent MI EEG classification. The findings of this study have important implications for Brain-Computer-Interface (BCI) research, as they highlight a promising method for overcoming the limitations posed by non-unified experimental setups. By enabling the integration of diverse datasets with varying electrode layouts, our proposed approach can help advance the development and application of BMI technologies.
description: 19 pages, 4 figures
ANTIBACTERIAL ACTIVITY OF LACTIC ACID BACTERIA ISOLATED FROM PROBIOTIC HEALTH DRINK YAKULT
Creators: name: P.MATHUMITHA
Publisher: name: Zenodo
Year: 2025
Subjects: Antimicroial activity, Probiotic drink , Lacticacid bacteria

description: Yakult is a popular probiotic drink that contains a specific strain of beneficial bacteria called Lactobacillus casei Shirota. It was developed in Japan by Dr. Minoru Shirota in the 1930s and is known for its potential digestive health benefits. The increase of antimicrobial resistance has required the exploration of other bio-therapeutic agents.  The capacity of lactic acid bacteria (LAB), which are well-known for their probiotic qualities, to generate antimicrobial chemicals has made them attractive candidates.  This study examined the antibacterial activity of LAB strains that were isolated from the commercially available probiotic health drink Yakult against a number of pathogenic pathogens, such as Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli.  De Man, Rogosa, and Sharpe (MRS) medium was used to cultivate the isolates, and their morphological and biochemical traits were used to identify them.  The agar well diffusion method was used to measure antimicrobial activity.
Effect of alkyl chain length in protic ionic liquids: an AIMD perspective
Creators: name: M. Campetella
name: M. Macchiagodena
name: L. Gontrani
name: B. Kirchner
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: In this study we have explored, by means of ab initio molecular dynamics, a subset of three different protic ionic liquids (ILs). We present both structural and dynamical information of the liquid state of these compounds as revealed by accurate ab initio computations of the interactions. Our analysis figures out the presence of a strong hydrogen bond network in the bulk state, that is more stable in those ILs characterised by a longer alkyl side chain. Indeed it becomes more long-lasting passing from ethyl ammonium to butyl ammonium, owing to the hydrophobic effects stemming from alkyl chain contacts. Furthermore, the relative free energy landscape of the cation–anion interaction exhibits a progressively deeper well as the side chain of the cation gets longer. The hydrogen bond interaction, as already mentioned in previous works, leads to loss of degeneracy of the asymmetric stretching vibrations of the nitrate anions. The resulting frequency splitting between the two normal modes is about 90 cm−1.
Long Noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment
Creators: name: Kaiming, Wu
name: Zhao, Zhenxian
name: Liu, Kuanzhi
name: Zhang, Jian
name: Li, Guanghua
name: Wang, Liang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biological processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3+CD8+T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.
Bivariate $P$-polynomial association schemes
Creators: name: Bernard, P. -A.
name: Crampe, N.
name: d'Andecy, L. Poulain
name: Vinet, L.
name: Zaimi, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Bivariate P-polynomial association scheme of type $(α,β)$ are defined as a generalization of the P-polynomial association schemes. This generalization is shown to be equivalent to a set of conditions on the intersection parameters. A number of known higher rank association schemes are seen to belong to this broad class. Bivariate Q-polynomial association schemes are similarly defined.
Liquid crystalline polymers XV. Synthesis, properties and cytotoxicity of photoresponsive thermotropic liquid crystalline copoly(arylidene-ether)s based on 4-tert-butylcyclohexanone and cyclohexanone moieties in the main chain
Creators: name: Aly, Kamal I.
name: Abdel-Rahman, Mona A.
name: Tolba, Amal H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: A new series of photoresponsive thermotropic liquid crystalline copoly(arylidene-ether)s based on both 4-tert-butylcyclohexanone and cyclohexanone moieties in the main chain were synthesised using solution polycondensation technique of both with different 4,4ʹ-diformyl-α,ω-diphenoxyalkane derivatives. Two model compounds were synthesised from the reaction of each cycloalkanone monomer with benzaldehyde, and their structures were determined using single crystal X-ray diffraction. The structure of the monomers and copolymers was confirmed by elemental and spectral analyses. In addition, the thermal stabilities of these copolymers were evaluated by thermogravimetric analysis. We performed both differential scanning calorimertric and polarised optical microscopic measurements to investigate the thermotropic liquid crystalline properties of synthesised copolymers. The UV−Vis absorption spectroscopy of the liquid crystalline copoly(arylidene-ether) 6f revealed that the system undergoes Entgegen/Zusammen (E/Z) photoisomerisation using UV lamp (450 nm). Moreover, the various characteristics of the prepared copolymers including: solubility, X-ray diffraction analysis, gel permeation chromatography (GPC) and scanning electron microscopy were determined and discussed. The cytotoxicity of the model compounds and selected examples of these copolymers was tested against MCF-7 breast cancer cells. All tested samples showed considerable results, where 6c copolymer gave the best result; it showed cytotoxicity against MCF-7 cell line with IC50 of 0.26 µM.
Do Polished, Tapered, Cemented Stems Implanted to Treat Neck of Femur Fracture Increase the Risk of Subsequent Periprosthetic Femur Fracture Compared to Matte Anatomical Stems? A Systematic Review
Creators: name: Staunton, Peter
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine

description: Incidence of hip fracture is increasing alongside ageing populations and with that come the inevitable complication. One such complication, periprosthetic fracture, is a costly condition to manage with high associated morbidity and mortality. There are many different risk factors associated with periprosthetic fractures and recent studies have suggested that the use of a polished tapered stem for treatment of neck of femur fractures in the elderly may increase risk when compared to use of a matte anatomical stem. We performed a systematic review of the literature to assess this risk. Review was performed by computer based search of online search engines by Cochrane Library, Embase, Medline, Web of Knowledge, SCOPUS, Google Scholar, OpenGrey, National Library of Medicine (NLM), OpenDOAR and Bielefeld Base. Inclusion criteria required observational studies reporting on a cohort where either polished tapered or matte anatomical stems were implanted to treat neck of femur fractures and periprosthetic fracture rate for the cohort was reported. We identified eight studies where either polished tapered or matte anatomical femoral stems were implanted to treat neck of femur fractures in elderly populations. The combined cohort comprised 7250 subjects with a mean weighted age of 83.17 years. Only one study was identified which compared the two stem types directly in the appropriate cohort. We estimated an increased risk for periprosthetic fracture with polished tapered stem (2.3%) when compared to a matte anatomical stem (0.5%) when implanted for treatment of neck of femur fracture (p-value 0.0002). Meta-analysis could not be performed due to the absence of two arm studies. Evidence of increased risk for periprosthetic fracture with the use of polished tapered stems in elderly populations after treatment for neck of femur fracture is inconclusive. Joint and hip fracture registry data may potentially be utilised to fully evaluate this risk compared to matte anatomical stems in order to identify required changes to practice.
Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations
Creators: name: Yan, Libo
name: Zhang, Li
name: Zhang, Yanmin
name: Qiao, Xin
name: Pan, Jing
name: Liu, Haichun
name: Lu, Shuai
name: Xiang, Bingren
name: Lu, Tao
name: Yuan, Haoliang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: c-Met kinase has been considered as an attractive target for developing antitumor agents. The strong interactions between Tyr1230 and the inhibitors emphasized its importance for ligand binding. The clinically related Tyr1230 mutations have made negative impacts on current c-Met kinase inhibitors, especially the exquisitely selective ones, like PF-04217903, while the multi-targeted inhibitors, like Crizotinib, were not affected so much. In this study, the protein–ligand interactions between c-Met kinase domain (wild, Y1230C and Y1230H) and these inhibitors were compared. The binding site was expanded and the post-mutated regions became solvent accessible. The heavy dependency of PF-04217903 on the interactions with Tyr1230 resulted in the steep decrease of its potency against the Y1230 mutants. It was found that the ligand entrance region contributed consistently to the binding of Crizotinib, but not PF-04217903. Additional groups substituted in the ligand entrance region with stable interactions should be beneficial for improving the inhibitory activity of PF-04217903 against the Y1230 mutants. These findings will facilitate the discovery of potent inhibitors against Y1230 mutated c-Met kinase.
Quasi-lisse extension of affine $\mathfrak{sl}_2$ à la Feigin--Tipunin
Creators: name: Creutzig, Thomas
name: Nakatsuka, Shigenori
name: Sugimoto, Shoma
Publisher: name: arXiv
Year: 2023
Subjects: subject: Representation Theory (math.RT)
subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study the affine analogue $\mathrm{FT}_p(\mathfrak{sl}_2)$ of the triplet algebra. We show that $\mathrm{FT}_p(\mathfrak{sl}_2)$ is quasi-lisse and the associated variety is the nilpotent cone of $\mathfrak{sl}_2$. We realize $\mathrm{FT}_p(\mathfrak{sl}_2)$ as the global sections of a sheaf of vertex algebras in the spirit of Feigin--Tipunin and thereby construct infinitely many simple modules and, in particular solve a conjecture by Semikhatov and Tipunin. We introduce the Kazama--Suzuki dual superalgebra $s\mathcal{W}_p(\mathfrak{sl}_{2|1})$ of $\mathrm{FT}_p(\mathfrak{sl}_2)$ and their singlet type subalgebras $s\mathcal{M}_p(\mathfrak{sl}_{2|1})$ and $\mathcal{M}_p(\mathfrak{sl}_2)$ and show their correspondence of categories. For $p=1$, we show the logarithmic Kazhdan--Lusztig correspondence for these (super)algebras and, in particular, show that the quantum group corresponding to $s\mathcal{M}_1(\mathfrak{sl}_{2|1})$ is the unrolled restricted quantum supergroup $u^H_{-1}(\mathfrak{sl}_{2|1})$ as suggested by Semikhatov and Tipunin.
description: 45 pages, comments are welcome!
A new bisabolane sesquiterpenoid and a new abietane diterpenoid from Cephalotaxus sinensis
Creators: name: Ahmed, Abrar
name: Li, Wei
name: Zhang, Jun-Sheng
name: Sam, Pek-Ha
name: Zou, Yi-Hong
name: Tang, Gui-Hua
name: Yin, Sheng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Phytochemical investigation of Cephalotaxus sinensis has led to the isolation of a new bisabolane sesquiterpenoid (1), a new abietane diterpenoid (2), and 13 known compounds (3–15). Their structures were elucidated by extensive spectroscopic analysis (MS, UV, IR, and NMR).
Training Needs Assessment
Creators: name: Davidson, Mary Frances
name: Asgeirsson, Thor
name: Brahim, Khallahi
name: Fall, Massal
name: Diallo, Mamadou
name: Da Cruz, Elisia
name: Fonseca, Benvindo
name: Lucas, Vincent
Publisher: name: Zenodo
Year: 2018
Subjects: SFPA - Sustainable Fisheries Partnership Agreements
Training
Fisheries management
Capacity building

description: The United Nations University Fisheries Training Programme (UNU-FTP) completed Training Needs Assessments in relation to the FarFish project in the four Case Study countries; Mauritania, Senegal, Cape Verde, and Seychelles. The primary aim of these assessments was to determine mutually agreed upon capacity building priorities to form the basis for training administered through work package 7 (WP7) in the FarFish project. These Training Needs Assessments targeted institutions partnering in the FarFish project within the case study countries and were conducted through site visits during which key staff were interviewed by UNU-FTP team. The initial results of these assessments were presented to FarFish partners on site at the end of the field visits, and input from FarFish partners were incorporated in this final Training Needs Assessment report.
Social causation and protest mobilization: why temporality and interaction matter
Creators: name: Anisin, Alexei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology

description: Social causation and protest mobilization: why temporality and interaction matter. Territory, Politics, Governance. In this study, fuzzy-set qualitative comparative analysis (fsQCA) is proposed as an alternate approach that can bring us closer to understanding the repression–mobilization puzzle. By analysing a variety of historical cases with fsQCA, I comparatively assess which conditions are most salient in being able to account for increased protest mobilization after severe state repression. In turn, this study sheds new light on the underlying dynamics of the repression–dissent nexus by evaluating previously identified variables and theoretical mechanisms in a new manner. It specifically accounts for protest event characteristics that are indicative of both space and time. Comparative analysis reveals that no condition can be considered to be necessary or sufficient for there to be increased mobilization after severe repression. After conducting configurational tests and sensitivity checks, two causal configurations do reveal that a combination of factors interacts to bring about the outcome. These include protest threat level, nonviolent protest strategy, campaign diversity, and geographic terrain. The results verify, and at the same time, improve on existing work in this field.
Constraining primordial non-Gaussianity by combining next-generation galaxy and 21 cm intensity mapping surveys
Creators: name: Jolicoeur, Sheean
name: Maartens, Roy
name: Dlamini, Simthembile
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Surveys of the matter distribution contain `fossil' information on possible non-Gaussianity that is generated in the primordial Universe. This primordial signal survives only on the largest scales where cosmic variance is strongest. By combining different surveys in a multi-tracer approach, we can suppress the cosmic variance and significantly improve the precision on the level of primordial non-Gaussianity. We consider a combination of an optical galaxy survey, like the recently initiated DESI survey, together with a new and very different type of survey, a 21 cm intensity mapping survey, like the upcoming SKAO survey. A Fisher forecast of the precision on the local primordial non-Gaussianity parameter $f_{\mathrm{NL}}$, shows that this multi-tracer combination, together with non-overlap single-tracer information, can deliver precision comparable to that from the CMB. Taking account of the largest systematic, i.e. foreground contamination in intensity mapping, we find that $σ(f_{\mathrm{NL}}) \sim 4$.
description: 10+5 pages, 4 figures, "Minor corrections, main results unchanged. Version accepted by EPJC"
Theoretical considerations from On the hydrogen activation by frustrated Lewis pairs in the solid state: benchmark studies and theoretical insights
Creators: name: Liu, Lei
name: Brandenburg, Jan Gerit
name: Grimme, Stefan
Publisher: name: The Royal Society
Year: 2017

description: Recently, the concept of small molecule activation by frustrated Lewis pairs (FLPs) has been expanded to the solid state showing a variety of interesting reactivities. Therefore, there is a need to establish a computational protocol to investigate such systems theoretically. In the present study, we selected several FLPs and applied multiple levels of theory, ranging from a semi-empirical tight-binding Hamiltonian to dispersion corrected hybrid density functionals. Their performance is benchmarked for the computation of crystal geometries, thermostatistical contributions, and reaction energies. We show that the computationally efficient HF-3c method gives accurate crystal structures and is numerically stable and sufficiently fast for routine applications. This method also gives reliable values for the thermostatistical contributions to Gibbs free energies. The meta-GGA TPSS-D3 evaluated in a projector augmented plane wave basis set is able to produce reaction electronic energies. The established protocol is intended to support experimental studies and to predict new reactions in the emerging field of solid-state FLPs.