cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of catecholamines in calcium homeostasis in fish hepatocytes.
Creators: name: Zhang, Jinrui.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Biology, Molecular.

description: The role of Ca$\sp{2+}$ in catecholamine actions on hepatocyte metabolism was studied in three fish species: American eel, brown bullhead and rainbow trout. The cellular Ca content, Ca$\sp{2+}$ fluxes across the cell membrane and cytosolic free-Ca$\sp{2+}$ concentration ((Ca$\sp2\rbrack\sb{\rm i}$) changes in Fura-2-loaded single hepatocytes were measured respectively using atomic absorption spectrophotometer, a $\sp{45}$Ca exchange technique and a computer-controlled microspectrofluorimeter technique. The results indicated the following about Ca$\sp{2+}$ and hepatocyte metabolism. First, fish hepatocytes contain higher Ca content than equivalent mammalian cells (8.25 $\pm$ 1.03 (eel) and 10.49 $\pm$ 1.26 (bullhead) $\mu$moles$\cdot$g$\sp{-1}$ wet wt., respectively). Second, Ca$\sp{2+}$ uptake is a passive or energy-independent process whereas Ca$\sp{2+}$ efflux may be an active or energy-dependent process. Third, Ca$\sp{2+}$ uptake was not significantly stimulated by the catecholamines studied. Fourth, Ca$\sp{2+}$ efflux was significantly stimulated by both epinephrine and phenylephrine in eel hepatocytes and these effects were blocked by the $\alpha$-antagonist phentolamine. The $\alpha$-agonist isoproterenol and $\beta$-antagonist propranolol did not affect basal or hormone-stimulated Ca$\sp{2+}$ efflux. Fifth, basal (Ca$\sp{2+}\rbrack\sb{\rm i}$ was similar in eel and trout hepatocytes, but significantly higher in bullhead cells (184 $\pm$ 23 nM). Sixth, (Ca$\sp{2+}\rbrack\sb{\rm i}$ was significantly increased in eel hepatocytes by either epinephrine or phenylephrine at 10$\sp{-7}$M, but not the $\beta$-agonist isoproterenol (4% increase). Epinephrine and phenylephrine were found to induce repeated $\rm Ca\sb{i}\sp{2+}$ transients (i.e., Ca$\sp{2+}$ oscillations) with variable patterns in individual eel hepatocytes. Trout hepatocytes exhibited little sensitivity to epinephrine with less than 20% of the cells tested showing changes in (Ca$\sp{2+}\rbrack\sb{\rm i}$ in response to catecholamines. Seventh, the initial rise in Ca$\sb{\rm i}\sp{2+}$ induced in eel hepatocytes by epinephrine was independent of external Ca$\sp{2+}$, although external Ca$\sp{2+}$ is required for the long-term maintenance of Ca$\sp{2+}$ oscillations. Bullhead cells depend totally on external Ca$\sp{2+}$ for increasing Ca$\sb{\rm i}\sp{2+}$. (Abstract shortened by UMI.)
In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions
Creators: name: Attia, Mohamed A
name: Nelson, Cassandra E
name: Offen, Wendy A
name: Jain, Namrata
name: Davies, Gideon J
name: Gardner, Jeffrey G
name: Brumer, Harry
Publisher: name: BioMed Central
Year: 2018

description: Background: Xyloglucan (XyG) is a ubiquitous and fundamental polysaccharide of plant cell walls. Due to its structural complexity, XyG requires a combination of backbone-cleaving and sidechain-debranching enzymes for complete deconstruction into its component monosaccharides. The soil saprophyte Cellvibrio japonicus has emerged as a genetically tractable model system to study biomass saccharification, in part due to its innate capacity to utilize a wide range of plant polysaccharides for growth. Whereas the downstream debranching enzymes of the xyloglucan utilization system of C. japonicus have been functionally characterized, the requisite backbone-cleaving endo-xyloglucanases were unresolved. Results: Combined bioinformatic and transcriptomic analyses implicated three glycoside hydrolase family 5 subfamily 4 (GH5_4) members, with distinct modular organization, as potential keystone endo-xyloglucanases in C. japonicus. Detailed biochemical and enzymatic characterization of the GH5_4 modules of all three recombinant proteins confirmed particularly high specificities for the XyG polysaccharide versus a panel of other cell wall glycans, including mixed-linkage beta-glucan and cellulose. Moreover, product analysis demonstrated that all three enzymes generated XyG oligosaccharides required for subsequent saccharification by known exo-glycosidases. Crystallographic analysis of GH5D, which was the only GH5_4 member specifically and highly upregulated during growth on XyG, in free, product-complex, and active-site affinity-labelled forms revealed the molecular basis for the exquisite XyG specificity among these GH5_4 enzymes. Strikingly, exhaustive reverse-genetic analysis of all three GH5_4 members and a previously biochemically characterized GH74 member failed to reveal a growth defect, thereby indicating functional compensation in vivo, both among members of this cohort and by other, yet unidentified, xyloglucanases in C. japonicus. Our systems-based analysis indicates distinct substrate-sensing (GH74, GH5E, GH5F) and attack-mounting (GH5D) functions for the endo-xyloglucanases characterized here. Conclusions: Through a multi-faceted, molecular systems-based approach, this study provides a new insight into the saccharification pathway of xyloglucan utilization system of C. japonicus. The detailed structural–functional characterization of three distinct GH5_4 endo-xyloglucanases will inform future bioinformatic predictions across species, and provides new CAZymes with defined specificity that may be harnessed in industrial and other biotechnological applications.
Angiotensin II and the control of humoral catecholamine release in fish.
Creators: name: Bernier, Nicholas J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Molecular.

description: The main goal of this thesis was to determine the relative importance of non-cholinergic secretagogues, primarily angiotensin II (Ang II), in the control of catecholamine release from the chromaffin tissue of fish. In rainbow trout (Oncorhynchus mykiss), immunohistochemical techniques and an in situ posterior cardinal vein (PCV) perfusion preparation provided direct evidence that Ang II can elicit catecholamine release from the chromaffin tissue via specific Ang II binding sites. Whereas the contribution of the renin-angiotensin system (RAS) to blood pressure recovery was largely indirect and relied on an Ang II-mediated secretion of catecholamines, the contribution from the sympathetic nervous system (SNS) was direct and relied on both plasma catecholamines and sympathetic nerves. In the American eel (Anguilla rostrata), injections of Ang II had no effect on humoral catecholamine release in either in situ PCV perfusion preparations or in chronically cannulated fish. The pressor effects of exogenous Ang II could not be attributed to any change in plasma catecholamine levels and the SNS does not appear to be an essential contributor to cardiovascular homeostasis during hypotension in the eel. The contributions of Ang II and humoral catecholamines to cardiovascular control were also investigated in an elasmobranch, the spiny dogfish ( Squalus acanthias). Whereas the contribution of catecholamines was direct, Ang II indirectly contributed to cardiovascular control by dose-dependent stimulation of catecholamine release. Results suggest that the control of catecholamine release from the chromaffin tissue of M. glutinosa can be achieved through hormonal and/or paracrine means and that ACTH, serotonin, and adenosine may all be involved. In summary, Ang II is a potent secretagogue of humoral catecholamine release in O. mykiss and S. acanthias. In both species, Ang II plays a significant role in the control of catecholamine release during acute hypotension, and this interaction represents an important physiological response for the maintenance of cardiovascular homeostasis. On the other hand, although previously suggested, Ang II does not appear to be a secretagogue of humoral catecholamine release in either A. rostrata or M. glutinosa. (Abstract shortened by UMI.)
title: Sundown towns and contemporary maternal-infant health
title: an interdisciplinary mixed-methods analysis of structural racism and its public health legacy in the Midwest
titleType: Subtitle
Creators: name: Belt, Leia Danae
Publisher: name: University of Iowa
Year: 2026
Subjects: birth outcomes
health disparities
Interdisciplinary
mixed-methods
structural racism
sundown towns
public abstract
African American Studies

description: Structural racism is a determinant of health and a fundamental cause of racial disparities in health. This dissertation employs an interdisciplinary, mixed-methods approach to investigate the impact of historical structural racism, as exemplified by sundown towns, on contemporary health outcomes, with a particular focus on birth outcomes. The initial paper elucidates the utility of sundown towns as a metric for assessing structural racism, drawing parallels to the historical practice of Homeowners Loan Corporation (HOLC) redlining. Subsequently, an in-depth case study of sundown towns in the state of Iowa provides a nuanced exploration of this phenomenon in an understudied Midwestern context. The third paper in this series employs multilevel logistic regression to analyze the relationship between multiple measures of sundown town exposure on Black-white disparities in maternal morbidity, preterm birth and low birth weight for all birthing women racialized as Black, Indigenous, Hispanic, Asian, Native Hawaiian, and another race compared to white women in Iowa as well as an additional analysis only including birthing women racialized as Black. Collectively, these scholarly papers contribute significantly to the academic discourse on structural racism, offering a framework for researchers dedicated to understanding its long-term implications on health equity, with particularly emphasis on birth outcomes.
Effectiveness and acceptability of resistance exercise breaks as a strategy to augment vascular insulin sensitivity during prolonged sitting in sedentary workers
Creators: name: Rogers, Emily M.
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: Sedentary behavior time has increased significantly over the last few decades due to increased sitting in the workplace, social settings, and during transportation. As 80% of Americans work in primarily sedentary jobs, where many sit for ~7 h per day, the workplace serves as a prime environment to implement strategies to reduce sedentarism. It is highly likely that sedentary behavior promotes cardiometabolic disease (CMD) risk via detrimental impacts to nitric oxide (NO)-mediated endothelial function. Notably, after just 3 h of uninterrupted sitting, blood flow and laminar shear stress in conduit arteries is decreased, which promotes a proatherogenic hemodynamic environment, leaving the vasculature susceptible to atherosclerotic disease development. Evidence also demonstrates that laminar shear stress is important for sensitizing the endothelium to the vasodilatory effects of insulin. Thus, prolonged exposure to sedentary behavior likely promotes decrements in vascular insulin sensitivity (VIS). Importantly, resistance exercise breaks (REB), performed to break up prolonged sedentary bouts, can successfully attenuate sitting-induced impairments in popliteal and femoral artery FMD during sedentary periods lasting 3–5 h. However, the effects of REB performed during an otherwise sedentary period on VIS have not yet been explored. Therefore, the first aim of this dissertation was to examine if performing 3-min REB during a 3-h sedentary period could augment VIS in the face of prolonged sitting. The second aim of this dissertation was to assess the acceptability of these REB and to understand how they impact productivity, discomfort, and sleepiness.
Einfluss der Nutzungsdauer von Produkten auf ihre Umweltwirkung: Schaffung einer Informationsgrundlage und Entwicklung von Strategien gegen "Obsoleszenz"
Creators: name: Prakash, Siddhartha
name: Dehoust, Günther
name: Gsell, Martin
Publisher: name: My University
Year: 2016
Subjects: subject: Geplante Obsoleszenz
subject: Lebenserwartung
subject: Nutzungsdauer
subject: Elektrogerät/Elektronikgerät
subject: Waschmaschine
subject: Obsoleszenz
subject: Werkstoffliche Obsoleszenz
subject: Psychologische Obsoleszenz
subject: Funktionale Obsoleszenz
subject: Lebensdauer
subject: Elektro- und Elektronikgeräte
subject: Fernsehgeräte
subject: Notebooks
subject: Reparaturkosten
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Das übergeordnete Ziel des Vorhabens ist, eine fundierte Datengrundlage zur Beschreibung und Beurteilung der Erscheinung Obsoleszenz bzw. der Trends der erreichten Produktlebensund Nutzungsdauer zu schaffen und darauf aufbauend handlungssichere Strategien gegen Obsoleszenz zu entwickeln. Die Ergebnisse zeigen, dass die Elektro- und Elektronikgeräte aus vielfältigen Gründen ersetzt werden. Dabei wirken werkstoffliche, funktionale, psychologische und ökonomische Obsoleszenzformen zusammen und erzeugen ein hochkomplexes Muster. Selbst die Ursachen der werkstofflichen Obsoleszenz sind in der Regel sehr divers und ermöglichen somit keine eindeutige Schwerpunktsetzung. Die Analyse bestätigt außerdem, dass die Erst-Nutzungsdauer von den meisten untersuchten Produktgruppen in den letzten Jahren abgenommen hat.
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
Creators: name: Bauersfeld, Stephan P.
name: Kessler, Christian S.
name: Wischnewsky, Manfred
name: Jaensch, Annette
name: Steckhan, Nico
name: Stange, Rainer
name: Kunz, Barbara
name: Brueckner, Barbara
name: Sehouli, Jalid
name: Michalsen, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Breast cancer
subject: Chemotherapy
subject: Fasting
subject: Pilot study
subject: Quality of life
subject: Ovarian cancer
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. Methods In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n = 18) or vice versa (group B;n = 16). Fasting started 36 h before and ended 24 h after chemotherapy (60 h-fasting period). QOL was assessed by the FACIT-measurement system. Results The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G = 5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4 ± 5.3 for fasted and 27.0 ± 6.3 for non-fasted cycles in group A and 14.1 ± 5.6 for non-fasted and 11.0 ± 5.6 for fasted cycles in group B. There were no serious adverse effects. Conclusion STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy. Trial registration This trial was registered at clinicaltrials.gov: NCT01954836.
Stoffeinträge in die lokale Umwelt aus Gebäuden und Bauprodukten
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Kommission Nachhaltiges Bauen
subject: KNBau
subject: Bauprodukte
subject: Bewertungssystem Nachhaltiges Bauen
subject: Bauprodukt
subject: Wirtschaft | Konsum

description: Nachhaltiges Bauen hat den Anspruch, einen hohen Standard zum Schutz der Umwelt und der Gesundheit vor gefährlichen Stoffen sicherzustellen. Die Kommission nachhaltiges Bauen am Umweltbundesamt (KNBau) sieht hier Umsetzungsdefizite und leitet daraus einen dringenden Handlungsbedarf ab. In diesem Positionspapier werden Wege aufgezeigt, mit denen Entscheidungsträger rechtliche Lücken schließen können, damit auch Hersteller konkrete Entwicklungsperspektiven erhalten und für Bauherren und Planer mehr Transparenz über die Freisetzung von gefährlichen Stoffen aus Bauprodukten geschaffen wird.
Quelle: Verlagsinformation
description: Nachhaltiges Bauen hat den Anspruch, einen hohen Standard zum Schutz der Umwelt und der Gesundheit vor gefährlichen Stoffen sicherzustellen. Die Kommission nachhaltiges Bauen am Umweltbundesamt (KNBau) sieht hier Umsetzungsdefizite und leitet daraus einen dringenden Handlungsbedarf ab. In diesem Positionspapier werden Wege aufgezeigt, mit denen Entscheidungsträger rechtliche Lücken schließen können, damit auch Hersteller konkrete Entwicklungsperspektiven erhalten und für Bauherren und Planer mehr Transparenz über die Freisetzung von gefährlichen Stoffen aus Bauprodukten geschaffen wird.
Evolution of the ca. 1.9 gallium Taltson magmatic zone, Northwest Territories: A neodymium isotope perspective.
Creators: name: Thériault, Réginald J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Geochemistry.

description: The Taltson magmatic zone is a north-trending belt of Early Proterozoic granitoids exposed over an area exceeding 18,000 km$\sp2$ in the Northwest Territories. Three petrologically and chronologically distinct intrusive suites comprise the Taltson zone. These are the 1986 Ma Deskenatlata suite, the 1955 to 1925 Ma Slave suite and the 1935 Ma Konth suite. The Deskenatlata suite is composed of a biotite-hornblende diorite to granite suite whose major and trace element chemistry supports derivation by arc magmatism. The Slave and Konth suites are leucocratic granitoids which contain numerous xenoliths of dominantly pelitic high grade paragneiss and display S-type granite mineralogy which commonly duplicates that of the pelitic gneisses. Bulk rock chemistry for the Konth suite is consistent with a homogeneous crustal magma source whereas the Slave suite is compositionally more heterogeneous. The Deskenatlata suite is considered as continental arc-derived granitoids resulting from eastward subduction of oceanic lithosphere beneath the Churchill Province. The Slave suite is regarded as the result of melting of various segments of heterogeneous Archean crust whereas the Konth may have evolved exclusively from melting of pelitic metasediments. (Abstract shortened by UMI.)
A case study of dynamic assessment and concept-based language instruction of the Chinese aspectual particle LE
Creators: name: Ma, Xi
Publisher: name: University of Iowa
Year: 2025
Subjects: public abstract

description: The Chinese aspectual marker LE is a challenging language construction for Chinese learners across proficiency levels due to its multiple form-meaning mappings. Previous studies on linguistic analyses, second language acquisition and pedagogy show a lack of design-based pedagogical research exploring the reasons underlying learner errors, including learner perspectives on learning difficulties and generating directly applicable implications for teaching and learning. This case study attempts to bridge the gap between previous linguistic and acquisition studies and pedagogical research by exploring an innovative teaching approach that integrates dynamic assessment (DA) and concept-based language instruction (C-BLI). This study further investigates the learner misconceptions, collects their feedback on mediations in DA and C-BLI, and generates implications on how C-BLI can be integrated into the pedagogical curriculum across proficiency levels.
description: This qualitative study aims to address two research questions: 1) How does dynamic assessment (DA) reveal learning difficulties and the development potential of learners across proficiency levels? and 2) How do learners across proficiency levels respond to mediated and Concept-based Language Instruction on LE? Participants of this study are four intermediate-level students and four advanced-level students enrolled in a Chinese program at an American college in the Midwest. Their performance on DA and responses to C-BLI mediated learning were analyzed and coded both inductively and deductively to summarize typical error types. Individual case reports were also generated for each participant to record their learning procedure and trajectory.
description: Results of this study show that learners lack coherent conceptual knowledge on the functions of LE because of over reliance on meaning-focused implicit grammar learning, which gives rise to one-to-one form-meaning mappings. However, they respond well to mediated learning based on the scientific concepts helping outline the underlying concepts of LE and connecting various functions holistically. The study highlights the significance of clear initial explicit knowledge presentation in grammar learning, specifically, it emphasizes the careful selection and presentation of concepts through conceptual maps in C-BLI. At the same time, the study discloses the interaction between individual differences such as prior knowledge and previous learning experience and the learner response to this teaching approach. It also accentuates the potential overshowing effects inhibiting conceptual establishment and expansion in explicit learning of grammar, which require contextualized learning and practice. Thus, the study calls for an integrated and balanced focus on form and meaning in future pedagogical practice.
Solubility and manipulation of disulfides in puroindoline-b: Recombinant puroindoline-b shows antifungal activity
Creators: name: Wu, Kechun
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Molecular.
subject: Agriculture, Plant Pathology.

description: Wheat (Triticum aestivum) kernel texture (hardness) is the most important determinant of milling and end-product quality. Recent data indicate that the only difference between soft and hard textured wheat is a single amino acid mutation in one protein, puroindoline-b (PIN-b). A rare tryptophan-rich domain in this protein consists of five tryptophan residues among a stretch of seven amino acid residues. To understand how this single mutation makes hard wheat possible, thus enabling bread making, it is crucial to have a high-resolution three-dimensional structure of this protein. The prerequisite for structural elucidation of any protein is the high-quality sample preparation. In this thesis PIN-b from a diploid wheat (Triticum monococcum ) was chosen as the model system because its grain is soft and it has the simplest genome of all wheats. The coding sequence of PIN-b was amplified from the diploid wheat using PIN-b specific primers. It was cloned into a protein expression vector. PIN-b was expressed as a protein behind the thioredoxin (TRX-a) tag. The TRX-a-PIN-b fusion protein was purified using nickel chelating chromatography. The immunological identity of the fusion protein was confirmed by Western blot. The PIN-b was released from the fusion protein by enterokinase proteolysis and purified using ion exchange chromatography. After glutathione treatment to facilitate full formation of the potential five disulfide bonds, PIN-b demonstrated higher fungicidal activity when compared to the non-treated PIN-b.
The SAMI Galaxy Survey: can we trust aperture corrections to predict star formation?
Creators: name: Richards, S. N.
name: Bryant, J. J.
name: Croom, S. M.
name: Hopkins, A. M.
name: Schaefer, A. L.
name: Bland-Hawthorn, J.
name: Allen, J. T.
name: Brough, S.
name: Cecil, G.
name: Cortese, Luca
name: Fogarty, L. M. R.
name: Gunawardhana, M. L. P.
name: Goodwin, M.
name: Green, A. W.
name: Ho, I.-T.
name: Kewley, L. J.
name: Konstantopoulos, I. S.
name: Lawrence, J. S.
name: Lorente, N. P. F.
name: Medling, A. M.
name: Owers, M. S.
name: Sharp, R.
name: Sweet, Sarah
name: Taylor, Edward
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: In the low-redshift Universe (z < 0.3), our view of galaxy evolution is primarily based on fibre optic spectroscopy surveys. Elaborate methods have been developed to address aperture effects when fixed aperture sizes only probe the inner regions for galaxies of ever decreasing redshift or increasing physical size. These aperture corrections rely on assumptions about the physical properties of galaxies. The adequacy of these aperture corrections can be tested with integralfield spectroscopic data. We use integral-field spectra drawn from 1212 galaxies observed as part of the SAMI Galaxy Survey to investigate the validity of two aperture correction methods that attempt to estimate a galaxy's total instantaneous star formation rate.We show that biases arise when assuming that instantaneous star formation is traced by broad-band imaging, and when the aperture correction is built only from spectra of the nuclear region of galaxies. These biases may be significant depending on the selection criteria of a survey sample. Understanding the sensitivities of these aperture corrections is essential for correct handling of systematic errors in galaxy evolution studies.
The role of public procurement in improving accessibility to ICT
Creators: name: Astbrink, Gunela
name: Tibben, William
Publisher: name: Swinburne
Year: 2024

description: Government bodies use public procurement policies and mechanisms to purchase ICT products and services. Some governments in OECD countries apply accessibility criteria when procuring ICT to improve access to their services and employment opportunities for people with disabilities. This may have a flow-on effect of greater availability of affordable and accessible ICT thus improving digital inclusion. This paper outlines research on comparative analysis of the situation in Australia with current policy in OECD countries. The research resulted in recommendations for a consumer-oriented plan to work with Australian governments on the introduction of accessibility criteria in ICT public procurement.
Improving the Prognostic Ability through Better Use of Standard Clinical Data - The Nottingham Prognostic Index as an Example
Creators: name: Winzer, Klaus-Jürgen
name: Buchholz, Anika
name: Schumacher, Martin
name: Sauerbrei, Willi
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Prognostic factors and prognostic models play a key role in medical research and patient management. The Nottingham Prognostic Index (NPI) is a well-established prognostic classification scheme for patients with breast cancer. In a very simple way, it combines the information from tumor size, lymph node stage and tumor grade. For the resulting index cutpoints are proposed to classify it into three to six groups with different prognosis. As not all prognostic information from the three and other standard factors is used, we will consider improvement of the prognostic ability using suitable analysis approaches. Methods and Findings Reanalyzing overall survival data of 1560 patients from a clinical database by using multivariable fractional polynomials and further modern statistical methods we illustrate suitable multivariable modelling and methods to derive and assess the prognostic ability of an index. Using a REMARK type profile we summarize relevant steps of the analysis. Adding the information from hormonal receptor status and using the full information from the three NPI components, specifically concerning the number of positive lymph nodes, an extended NPI with improved prognostic ability is derived. Conclusions The prognostic ability of even one of the best established prognostic index in medicine can be improved by using suitable statistical methodology to extract the full information from standard clinical data. This extended version of the NPI can serve as a benchmark to assess the added value of new information, ranging from a new single clinical marker to a derived index from omics data. An established benchmark would also help to harmonize the statistical analyses of such studies and protect against the propagation of many false promises concerning the prognostic value of new measurements. Statistical methods used are generally available and can be used for similar analyses in other diseases.
‘They think I’m really cool and nice’: The impact of Internet support on the social networks and loneliness of young people with disabilities
Creators: name: Raghavendra, Parimala
name: Grace, Emma
name: Newman, Lareen
name: Wood, Denise
name: Connell, Tim
Publisher: name: Swinburne
Year: 2024

description: Today, young people use the Internet for social networking, learning and recreation. Young people with disabilities have fewer friends and reduced social networks. The aim was to investigate the effectiveness of one-on-one training to increase the use of the Internet by young people with disabilities to enhance their social networks and reduce loneliness. Eighteen young people aged 10-18 years with cerebral palsy, physical disability or acquired brain injury completed a social networks inventory and level of loneliness measure. Participants received assistive technology and training at their home to learn to use the Internet for building social networks. Post intervention testing revealed that the number of online communication partners increased significantly; however, there was no difference in measured levels of loneliness. Future research with larger number of participants with disabilities needs to be followed up longitudinally including investigating the meaning and role of online social connections for this group.
The study of nanoscale water confinement in metal-organic nanotubes
Creators: name: Jahinge, Tiron Hasitha Lakmal
Publisher: name: University of Iowa
Year: 2025

description: Water under confinement exhibits properties that differ significantly from bulk water due to frustration of the hydrogen-bond network induced by interactions with the pore wall. Much of the previous work has focused on water confined within carbon nanotubes, which possess hydrophobic environment, or in hydrophilic silica-based nanoporous materials. Complex materials often possess variability in the polarity of the surface and the exact arrangement of these hydrophobic and hydrophilic functional groups may control the structure and behavior of water in these systems. To evaluate this further, we are exploring the behavior of water within hybrid metal organic nanotubes, which possess 1D pore space.
description: In Forbes group, a uranium-based metal-organic nanotube (UMONT) was synthesized using zwitterionic ligands like iminodiacetic acid (IDA). IDA chelates to the U(VI) metal center in a tridentate fashion and doubly protonated IDA linker connects the neighboring uranyl moieties until it forms hexameric macrocycles. These macrocycles stack into a nanotubular array due to supramolecular interactions. Single crystal X-ray diffraction studies displayed there are two crystallographically unique water molecules that can be removed reversibly at 37 ˚C. In the current body of work, we are trying to understand the fundamentals of water behavior within this 1D nanoporous material by changing physicochemical properties such as temperature and pressure.
description: The single crystal XRD data for UMONT was collected at temperatures ranging from 100 to 270 K with a 10 K increment, and a method was developed to track the changes in electron density at confined water sites over the temperature series. This was done to understand the mobility of water with external temperature changes. The influence of internal polarity on the hydrogen bonding network within hybrid materials was investigated using two different MONT materials (copper-based MONT (Cu-LaMONT) and lanthanum-based MONT (LaMONT)) as model systems, and their hydrogen bonding networks were compared with that of UMONT. The changes in the hydrogen bonding network with temperature variation from 100 to 250 K were analyzed to gain a deeper understanding of the polarity effect and electron density mapping was used to observe the changes in confined water structure. This polarity effect on proton conductivity through the water network within UMONT and Cu-LaMONT was measured using electrochemical impedance spectroscopy, varying the external humidity and temperature. Another study, the effect of external pressure on the confined water structure within UMONT was studied by conducting in situ and ex situ pressurization using an environmental control cell (ECC) and a Parr vessel, respectively.
title: Die Bedeutung der Konzepte One Health und Planetary Health fur die Umweltmedizin im 21. Jahrhundert
title: The implications of the concepts One Health and Planetary Health for the environmental medicine of the 21st century
titleType: AlternativeTitle
Creators: name: Kümpfel, Romy
name: Straff, Wolfgang
name: Niemann, Hildegard
name: Zschachlitz, Tomke
Publisher: name: My University
Year: 2023
Subjects: Planetarische Grenzen
Umwelt und Gesundheit
Klimaänderung
Volksgesundheit

description: Im 21. Jahrhundert führt eine Anhäufung komplexer Krisen wie Klimawandel, Biodiversitätsverlust, Umweltverschmutzungen, Kriege und Pandemien zu ökonomischen, sozialen und gesundheitlichen Problemen für Menschen jetziger und zukünftiger Generationen. Diese Probleme sind im Wesentlichen auf die Missachtung natürlicher Regenerationskapazitäten von Ökosystemen zurückzuführen. Gesundheitsansätze wie One Health und Planetary Health haben seit Beginn der 2000er-Jahre an Popularität gewonnen und finden verstärkt Anwendung in der Politik, der Wissenschaft und in den Gesundheitsberufen. Auch die Umweltmedizin wird durch die wachsende Zahl von Krisen und Umweltproblemen sowie das zunehmende Interesse an den Konzepten One Health und Planetary Health beeinflusst. In diesem Diskussionsbeitrag wird zunächst die Entwicklung der beiden Konzepte dargestellt. Danach wird auf ihre Bedeutung für die Umweltmedizin eingegangen. Ärztinnen und Ärzte, die sich mit umweltmedizinischen Themen befassen, müssen bei der Beurteilung von Umwelteinflüssen heute sowohl lokale als auch globale Ursachen und Gesundheitseffekte bedenken, was Entscheidungen komplizierter machen und zu Zielkonflikten führen kann. Quelle: © Der/die Autor(en) 2023
description: In the 21st century, an accumulation of complex crises such as climate change, biodiversity loss, environmental pollution, wars, and pandemics is leading to economic, social, and health problems for people of current and future generations. These problems are essentially due to the disregard of natural regenerative capacities of ecosystems. Health approaches such as One Health and Planetary Health have gained popularity since the early 2000s and are increasingly used in politics, science, and the health professions. Environmental medicine is also influenced by the growing number of crises and environmental problems and the increasing interest in the concepts of One Health and Planetary Health. In this discussion paper, the development of the two concepts is first presented. Then, their significance for environmental medicine will be discussed. Health professionals working on environmental medicine issues must now consider both local and global causes and health effects when assessing environmental impacts, which can complicate decisions and lead to conflicting objectives. Quelle: © Der/die Autor(en) 2023
title: "We talk it over"
title: mixed-method study of interdisciplinary collaborations in private practice among urologists and oncologists in Germany
titleType: Subtitle
Creators: name: Beermann, Sandra
name: Chakkalakal, Denny
name: Muckelbauer, Rebecca
name: Weißbach, Lothar
name: Holmberg, Christine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Utilisation of multidisciplinary teams is considered the best approach to care and treatment for cancer patients. However, the multidisciplinary approach has mainly focused on inpatient care rather than routine outpatient care. The situation in private practice care and outpatient care is gradually changing. We aimed to 1), investigate interdisciplinary cooperations in the care of tumor patients among urologists and oncologists in the community setting, 2), establish an estimate of the prevalence of cooperation among oncologists and organ-specific providers in community settings in Germany and 3), characterise existing cooperations among oncologists and urologists. Methods We conducted simultaneously a cross- sectional survey with private practice urologists (n = 1,925) and a qualitative study consisting of semi-structured interviews with urologists and oncologists (n = 42), primarily with private practices, who had indicated cooperation the care of urological tumor patients. Results Most of the participants (66%) treated their own tumor patients. When physicians referred patients, they did so for co- and subsequent treatments (43%). Most cooperating urologists were satisfied with the partnership and appreciated the competency of their partners. Qualitative interviews revealed two types of collaboration in the community setting: formal and informal. Collaborations were usually ongoing with many physicians and depended equally on both patient preference and diagnosis. Conclusion Joint patient treatment requires clear delineation of roles and responsibilities and simple means of communication. Formal frameworks should allow for incorporation of patients’ critical role in collaboration decisions in treatment and care.
Zum Casimir-Effekt-Energiedichte des freien Klein-Gordon-Feldes vor statischen klssischen Hintergründen
Creators: name: Fischer, David-Johannes
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2007
Subjects: thesis
effect: Casimir
Klein-Gordon equation
energy: density
field theory: scalar
operator: Laplace
background: classical

description: Universität Hamburg, Diplomarbeit, 2007; 76 pp., (2007). doi:10.3204/DESY-THESIS-2008-001
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
An exploratory study of the needs of immigrant women offenders
Creators: name: Delic, Svjetlana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Sociology, Criminology and Penology.

description: This study explores the needs of immigrant women in Canadian federal correctional facilities. It specifically examines whether they have any unique needs that stem directly from their immigration status and migration-related hardships. My research included ten in-depth interviews with immigrant women prisoners at the Grand Valley Institution for Women in Ontario and a questionnaire sent to all foreign-born women in Canadian federal correctional institutions (one institution did not have any immigrant offenders at the time). Seven need areas, which were derived from the literature, were explored during the interview: culture-specific programming, migration-related sources of stress, problems with seeking psychological help, parenting issues, vocational skills, language skills, and immigration-related concerns. Considering that existing literature does not specifically identify the unique needs of immigrant female offenders, it appeared more appropriate to develop the questionnaire following the analysis of the interviews. Consequently, some additional themes, not identified in the literature on immigrants, emerged during the interviews and were included in the questionnaire. For example, some of the interviewees identified additional concerns, such as not having access to culture-specific foods and products; having strained relationships with their extended families; or feeling that their culture-specific behavior was misread by the correctional staff. I situated my research findings and proposed recommendations within a broader context of Canadian debates on multiculturalism. Immigrant women belong to various ethno-cultural groups and both they and the correctional system are affected by Canadian multicultural practices.
Post-occupancy evaluation : state-of-the- art analysis and state-of-the-practice review
Creators: name: Li, Peixian
name: Brager, Gail
name: Froese, Thomas M.
Publisher: name: Building and Environment
Year: 2018

description: Post-occupancy evaluation (POE) is a process of evaluating the performance of a building after it has been occupied for at least several years. The authors conducted a comprehensive and critical review to provide a both qualitative and quantitative introduction of POE, including a brief introduction of the history, definition and benefits of POE, a statistical analysis of 146 POE projects since 2010, a comparison of 13 existing POE protocols, a summary of emerging research focuses, and potential future research areas. The 146 POE projects were analyzed in terms of building types, countries, purposes, methods used, and key findings. The review of 13 POE protocols show the state-of-the-practice POE techniques. Apart from POE projects, the authors present emerging research topics related to the visualization of POE results, analyses of occupant survey database, and measurement of occupancy. Finally, the discussion summarizes the current condition of POE research and proposes five transitions that POE efforts should pursue: from one-off to continuing, from high-level to detailed, from researchers-oriented to owners/occupants-oriented, from academia to industry, and from independent to integrated. This paper provides a thorough introduction of POE to the beginners in this area, as well as informing more seasoned investigators about the trends, gaps, and potential future directions in POE research.
Evaluierung der Bundeswettbewerbe Nachhaltige Tourismusdestinationen 2012/13 und 2016/17 (DTV, BMU, BfN) zur Förderung und Weiterentwicklung nachhaltiger Destinationen in Deutschland
Creators: name: Feil, Thomas
name: Bojunga, Heike
name: Handke, Volker
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Sanfter Tourismus
subject: Nachhaltiger Tourismus
subject: Destinationen
subject: Wettbewerb
subject: Wirtschaft | Konsum
subject: Nachhaltigkeit | Strategien | Internationales

description: Der Ergebnisbericht ist eine Zusammenfassung der Gesamtergebnisse aus dem Vorhaben "Evaluierung der Bundeswettbewerbe Nachhaltige Tourismusdestinationen 2012/13 und 2016/17 (DTV, BMU, BfN) zur Förderung und Weiterentwicklung nachhaltiger Destinationen in Deutschland", das von April 2019 bis Februar 2021 durchgeführt wurde. Ziel des Vorhabens war die Evaluation der Zielerreichung und der erzeugten Wirkung der beiden Bundeswettbewerbe sowie ihrer begleitenden Öffentlichkeitsarbeit. Auf der Basis der Evaluationsergebnisse und vergleichbarer Wettbewerbe werden Empfehlungen für die Neuausrichtung und Weiterentwicklung der Bundeswettbewerbe abgeleitet. Quelle: Forschungsbericht
description: The report is a summary of the overall results from the project "Evaluation of the federal competitions for sustainable tourism destinations 2012/13 and 2016/17 (DTV, BMU, BfN) for the promotion and further development of sustainable destinations in Germany", which ran from April 2019 to February 2021 was carried out. The aim of the project was to evaluate the achievement of objectives and the effects generated by the two national competitions as well as their accompanying public relations work. On the basis of the evaluation results and comparable competitions, recommendations for the realignment and further development of the national competitions are derived. Quelle: Forschungsbericht
description: Der Ergebnisbericht ist eine Zusammenfassung der Gesamtergebnisse aus dem Vorhaben „Evaluierung der Bundeswettbewerbe Nachhaltige Tourismusdestinationen 2012/13 und 2016/17 (DTV, ⁠BMU⁠, ⁠BfN⁠) zur Förderung und Weiterentwicklung nachhaltiger Destinationen in Deutschland. Ziel des Vorhabens war die Evaluation der Zielerreichung und der erzeugten Wirkung der beiden Bundeswettbewerbe sowie ihrer begleitenden Öffentlichkeitsarbeit. Auf der Basis der Evaluationsergebnisse und vergleichbarer Wettbewerbe werden Empfehlungen für die Neuausrichtung und Weiterentwicklung der Bundeswettbewerbe abgeleitet.
title: Mediated black girlhoods
title: a multi-level, comparative analysis of narrative feature films
titleType: Subtitle
Creators: name: Covington, Lisa D.
Publisher: name: University of Iowa
Year: 2026
Subjects: black girlhood
content analysis
film
youth
public abstract
African American Studies

description: Over the course of a century, there has been limited scholarship directly regarding Black youth actors’—specifically girls’—film content in illustrating their social engagement and characters’ engagement with social institutions. Popular culture has brought the representation of Black youth to the mainstream and scholarship recognized the need for diverse media content, there is a need to move beyond representation to understand the complexity of Black girls’ relationality to social institutions. This dissertation is a comparative, multi-level qualitative study conceptualizing Black girl identities, or mediated Black girlhoods, as characters in narrative feature films. In conducting comparative analyses across films, I utilized two theoretical frameworks: oppositional gaze and the matrix of domination. hooks’ oppositional gaze theory challenges dominant film spectatorship epistemologies. This investigation centers Black female spectatorship of media in querying characters’ engagement with social institutions (e.g., family, school, law enforcement, etc.). Early depictions of Black girlhood are largely in the form of supporting characters and flashback sequences in films including Claudine (1974) and God’s Stepchildren (1937). By extending Collins’ conceptual framework of the matrix of domination—an understanding that all social institutions are connected and inherently inequitable—this research approaches film as illustrating Black girls’ interactions within schools and police, as two social institutions that include amalgamations of patriarchy and racism. In developing both a digital timeline and compendious filmography of Black girls in film and sociopolitical analysis of their contemporary portrayal. This research not only identifies the first Black girl in film, but also deepens our understanding of the portrayal and relationality of her successors.
Le jardin des hélices.
Creators: name: Leduc, Natali.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Literature, Canadian (French).

description: Le Jardin des helices est le texte duquel Jerome Bosch a plagie par anticipation la structure pour effectuer le triptyque Le Jardin des helices. La demarche s'impregne de l'esprit pataphysicien, "science des solutions imaginaires" (Alfred Jarry), et tout specialement de l'Oulipo (Ouvroir de litterature potentielle). Le recit offre la mise en pratique d'une contrainte elaboree a partir de reflexions sur le plagiat par anticipation et sur les composantes du tableau de Jerome Bosch, tout specialement les plans et les lignes. La notion de plagiat par anticipation lancee par l'Oulipo se trouve enrichie d'une application ainsi que d'une reflexion sur le processus complexe qu'elle engendre.