cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Variation in serotonin neurotransmission genes affects neural activation during response inhibition in adolescents and young adults with ADHD and healthy controls
Creators: name: Rooij, Daan Van
name: Hartman, Catharina A.
name: Donkelaar, Marjolein M.J. Van
name: Bralten, Janita
name: Rhein, Daniel Von
name: Hakobjan, Marina
name: Franke, Barbara
name: Heslenfeld, Dirk J.
name: Oosterlaan, Jaap
name: Rommelse, Nanda
name: Buitelaar, Jan K.
name: Hoekstra, Pieter J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics

description: Objectives. Deficits in response inhibition have been associated with attention-deficit/hyperactivity disorder (ADHD). Given the role of serotonin in ADHD and impulsivity, we postulated that genetic variants within the serotonin pathway might influence response inhibition. Methods. We measured neural activation during stop-signal task performance in adolescents with ADHD (N = 185), their unaffected siblings (N = 111), and healthy controls (N = 124), and investigated the relationship of two serotonin gene polymorphisms (the rs6296 SNP of the HTR1B gene and HTTLPR variants of the 5-HTT gene) with the neural correlates of response inhibition. Results. The whole-brain analyses demonstrated large scale neural activation differences in the inferior and medial frontal and temporal/parietal regions of the response inhibition network between the different variants of both the HTR1B and 5HTT genes. Activation in these regions was significantly associated with stop-task performance, but not with ADHD diagnosis or severity. No associations were found between HTR1B and 5HTT variants and ADHD or ADHD-related neural activation. Conclusions. These results provide novel evidence that serotonin may play an important role in the neurobiology of response inhibition. Although response inhibition is strongly linked to ADHD, serotonin linked genetic variants associated with response inhibition and its neural correlates do not explain variance of the ADHD phenotype.
Turcinoemacheilus saadii Esmaeili, Sayyadzadeh, Ozulud, Geiger & Freyhof 2014
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Nemacheilidae
Turcinoemacheilus
Turcinoemacheilus saadii

description: 76. Turcinoemacheilus saadii Esmaeili, Sayyadzadeh, Özuluð, Geiger & Freyhof, 2014
Common name. Saadi dwarf loach
Taxonomy. Original description: Turcinoemacheilus saadii Esmaeili, Sayyadzadeh, Özuluð, Geiger & Freyhof, 2014: 268, figs. 7c, 13-15 [ars province, stream Tang-e-Tizab, a tributary to Bashar River which drains to the Karoun, 30°23'12"N, 51°46'50"E, Iran; holotype: ZM-CBSU 7169 B].
Revisions. None.
Illustrations. Esmaeili et al. (2014: 268, fig. 7).
Distribution in Iran. —Distribution in River Basin: Tigris.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Endemic].—Loch mahi-e kotolye Saadi.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 30, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Academic performance of students from entrance to graduation via quasi U-statistics: a study at a Brazilian research university
Creators: name: Maia, Rafael Pimentel
name: Hildete Prisco Pinheiro
name: Aluísio Pinheiro
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology

description: We present novel methodology to assess undergraduate students' performance. Emphasis is given to potential dissimilar behaviors due to high school background and gender. The proposed method is based on measures of diversity and on the decomposability of quasi U-statistics to define average distances between and within groups. One advantage of the new method over the classical analysis of variance is its robustness to distributional deviation from the normality. Moreover, compared with other nonparametric methods, it also includes tests for interaction effects which are not rank transform procedures. The variance of the test statistic is estimated by jackknife and p-values are computed using its asymptotic distribution. A college education performance data is analyzed. The data set is formed by students who entered in the University of Campinas, Brazil, between 1997 and 2000. Their academic performance has been recorded until graduation or drop-out. The classical ANOVA points to significant effects of gender, type of high school and working status. However, the residual analysis indicates a highly significant deviation from normality. The quasi U-statistics nonparametric tests proposed here present significant effect of interaction between type of high school and gender but did not present a significant effect of working status. The proposed nonparametric method also results in smaller error variances, illustrating its robustness against model misspecification.
Microstructures, mechanical properties and in vitro corrosion behaviour of biodegradable Mg–Zr–Ca alloys
Creators: name: Zhou, Ying-Long
name: Li, Yuncang
name: Luo, Dong-Mei
name: Wen, Cuie
name: Hodgson, Peter
Publisher: name: Swinburne
Year: 2024

description: The microstructures, mechanical properties, corrosion behaviour and biocompatibility of the Mg-Zr-Ca alloys have been investigated for potential use in orthopaedic applications. The microstructures of the alloys were examined using X-ray diffraction analysis, optical microscopy and scanning electron microscopy. The mechanical properties of Mg-Zr-Ca alloys were determined from compressive tests. The corrosion behaviour has been investigated using an immersion test and electrochemical measurement. The biocompatibility was evaluated by cell growth factor using osteoblast-like SaOS2 cell. The experimental results indicate that the hot-rolled Mg-Zr-Ca alloys exhibit much finer microstructures than the as-cast Mg-Zr-Ca alloys which show coarse microstructures. The compressive strength of the hot-rolled alloys is much higher than that of the as-cast alloys and the human bone, which would offer appropriate mechanical properties for orthopaedic applications. The corrosion resistance of the alloys can be enhanced significantly by hot-rolling process. Hot-rolled Mg-0.5Zr-1Ca alloy (wt %) exhibits the lowest corrosion rate among all alloys studied in this paper. The hot-rolled Mg-0.5Zr-1Ca and Mg-1Zr-1Ca alloys exhibit better biocompatibility than other studied alloys and possess advanced mechanical properties, corrosion resistance and biocompatibility, suggesting that they have a great potential to be good candidates for orthopaedic applications.
A Computational Study of How Orientation Bias in the Lateral Geniculate Nucleus Can Give Rise to Orientation Selectivity in Primary Visual Cortex
Creators: name: Kuhlmann, Levin
name: Vidyasagar, Trichur R.
Publisher: name: Swinburne
Year: 2024

description: Controversy remains about how orientation selectivity emerges in simple cells of the mammalian primary visual cortex. In this paper, we present a computational model of how the orientation-biased responses of cells in lateral geniculate nucleus (LGN) can contribute to the orientation selectivity in simple cells in cats. We propose that simple cells are excited by lateral geniculate fields with an orientation-bias and disynaptically inhibited by unoriented lateral geniculate fields (or biased fields pooled across orientations), both at approximately the same re tinotopic co-ordinates. This interaction, combined with recurrent cortical excitation and inhibition, helps to create the sharp orientation tuning seen in simple cell responses. Along with describing orientation selectivity, the model also accounts for the spatial frequency and length-response functions in simple cells, in normal conditions as well as under the influence of the GABA A antagonist, bicuculline. In addition, the model captures the response properties of LGN and simple cells to simultaneous visual stimulation and electrical stimulation of the LGN. We show that the sharp selectivity for stimulus orientation seen in primary visual cortical cells can be achieved without the excitatory convergence of the LGN input cells with receptive fields along a line in visual space, which has been a core assumption in classical models of visual cortex. We have also simulated how the full range of orientations seen in the cortex can emerge from the activity among broadly tuned channels tuned to a limited number of optimum orientations, just as in the classical case of coding for color in trichromatic primates.
Parameter and state estimation for a class of neural mass models
Creators: name: Postoyan, Romain
name: Chong, Michelle
name: Nešić, Dragan
name: Kuhlmann, Levin
Publisher: name: Swinburne
Year: 2024

description: We present an adaptive observer which asymptotically reconstructs the parameters and states of a model of interconnected cortical columns. Our study is motivated by the fact that the considered model is able to realistically reproduce patterns seen on (intracranial) electroencephalograms (EEG) by varying its parameters. Therefore, by estimating its parameters and states, we could gain a better understanding of the mechanisms underlying neurological phenomena such as seizures, which might lead to the prediction of the onsets of epileptic seizures. Simulations are performed to illustrate our results.
Oral and inhaled glucocorticoid use and risk of Achilles or biceps tendon rupture: a population-based case-control study
Creators: name: Spoendlin, Julia
name: Meier, Christian
name: Jick, Susan S.
name: Meier, Christoph R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biophysics

description: Background. Tendinotoxicity of glucocorticoids (GC) has been shown, but evidence on how this translates into clinical practice remains scarce.Objectives. To explore the association between oral or inhaled GC use and the risk of Achilles or biceps tendon rupture (ATR/BTR).Methods. We identified patients aged 18 to 89 years with incident ATR or BTR (1995–2013) for a matched (1:4) case-control analysis using the UK-based Clinical Practice Research Datalink. We stratified oral GC use by indication, timing and duration of use, continuous versus intermittent use, cumulative dose, and average daily dose. We stratified inhaled GC use by timing and number of prescriptions.Results. Among 8,202 cases, we observed increased odds ratios (ORs) around 3.0 for continuous oral GC use, which declined shortly after therapy cessation (similarly across indications). Odds ratios increased with average daily dose (≥ 10 mg/day, OR 4.05, 95% CI 2.32–7.08) and were elevated after one cycle of high-dose oral GC (≥ 20 mg/day). There was no effect of inhaled GC at any level of exposure.Conclusion. Our results provide evidence that oral GC therapy increases the risk of tendon rupture in a dose–response relationship. A single short-term high-dose GC treatment course may be sufficient transiently to increase the risk of tendon rupture.
AN EMPIRICAL STUDY OF SUSTAINABLE BUYING BEHAVIORS OF PAKISTANI CONSUMERS TOWARD CHINESE PRODUCTS
Creators: name: Hashim Ali, Abdul Majeed Khan
Publisher: name: TuEngr Group
Year: 2020
Subjects: Product quality
Product price
Product brand
Product promotion
Sustainable consumer buying behavior.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 4, 11A04L: 1-12
Adapting the 14-day rule for embryo research to encompass evolving technologies.
Creators: name: Williams, Kate
name: Johnson, Martin H
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Embryonic stem cells
Ethics
Warnock
Hfe Act
14-Day Rule
In-vitro Embryo Development

description: We consider the scientific evidence that research on in-vitro development of embryos beyond 14 days is necessary. We then examine potential new developments in the use of stem cells to make embryoids or synthetic human entities with embryo-like features, and consider whether they also require legal control. Next, we consider the arguments advanced against extending the 14-day period during which research on human embryos is currently permitted, and find none of them to be convincing. We end by proposing a new objective limit that could serve as a mechanism for regulating the use of embryos for research in vitro.
Decision-making flexibility in New Caledonian crows, young children and adult humans in a multi-dimensional tool-use task.
Creators: name: Miller, Rachael
name: Gruber, Romana
name: Frohnwieser, Anna
name: Schiestl, Martina
name: Jelbert, Sarah A
name: Gray, Russell D
name: Boeckle, Markus
name: Taylor, Alex H
name: Clayton, Nicola S
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: The ability to make profitable decisions in natural foraging contexts may be influenced by an additional requirement of tool-use, due to increased levels of relational complexity and additional work-effort imposed by tool-use, compared with simply choosing between an immediate and delayed food item. We examined the flexibility for making the most profitable decisions in a multi-dimensional tool-use task, involving different apparatuses, tools and rewards of varying quality, in 3-5-year-old children, adult humans and tool-making New Caledonian crows (Corvus moneduloides). We also compared our results to previous studies on habitually tool-making orangutans (Pongo abelii) and non-tool-making Goffin's cockatoos (Cacatua goffiniana). Adult humans, cockatoos and crows, but not children and orangutans, did not select a tool when it was not necessary, which was the more profitable choice in this situation. Adult humans, orangutans and cockatoos, but not crows and children, were able to refrain from selecting non-functional tools. By contrast, the birds, but not the primates tested, struggled to attend to multiple variables-where two apparatuses, two tools and two reward qualities were presented simultaneously-without extended experience. These findings indicate: (1) in a similar manner to humans and orangutans, New Caledonian crows and Goffin's cockatoos can flexibly make profitable decisions in some decision-making tool-use tasks, though the birds may struggle when tasks become more complex; (2) children and orangutans may have a bias to use tools in situations where adults and other tool-making species do not.
Mechanisms of seizure propagation in 2-dimensional centre-surround recurrent networks
Creators: name: Hall, David
name: Kuhlmann, Levin
Publisher: name: Swinburne
Year: 2024

description: Understanding how seizures spread throughout the brain is an important problem in the treatment of epilepsy, especially for implantable devices that aim to avert focal seizures before they spread to, and overwhelm, the rest of the brain. This paper presents an analysis of the speed of propagation in a computational model of seizure-like activity in a 2-dimensional recurrent network of integrate-and-fire neurons containing both excitatory and inhibitory populations and having a difference of Gaussians connectivity structure, an approximation to that observed in cerebral cortex. In the same computational model network, alternative mechanisms are explored in order to simulate the range of seizure-like activity propagation speeds (0.1-100 mm/s) observed in two animal-slice-based models of epilepsy: (1) low extracellular , which creates excess excitation and (2) introduction of gamma-aminobutyric acid (GABA) antagonists, which reduce inhibition. Moreover, two alternative connection topologies are considered: excitation broader than inhibition, and inhibition broader than excitation. It was found that the empirically observed range of propagation velocities can be obtained for both connection topologies. For the case of the GABA antagonist model simulation, consistent with other studies, it was found that there is an effective threshold in the degree of inhibition below which waves begin to propagate. For the case of the low extracellular model simulation, it was found that activity-dependent reductions in inhibition provide a potential explanation for the emergence of slowly propagating waves. This was simulated as a depression of inhibitory synapses, but it may also be achieved by other mechanisms. This work provides a localised network understanding of the propagation of seizures in 2-dimensional centre-surround networks that can be tested empirically.
The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition).
Creators: name: Fugazzola, Paola
name: Ceresoli, Marco
name: Agnoletti, Vanni
name: Agresta, Ferdinando
name: Amato, Bruno
name: Carcoforo, Paolo
name: Catena, Fausto
name: Chiara, Osvaldo
name: Chiarugi, Massimo
name: Cobianchi, Lorenzo
name: Coccolini, Federico
name: De Troia, Alessandro
name: Di Saverio, Salomone
name: Fabbri, Andrea
name: Feo, Carlo
name: Gabrielli, Francesco
name: Gurrado, Angela
name: Guttadauro, Angelo
name: Leone, Leonardo
name: Marrelli, Daniele
name: Petruzzelli, Luca
name: Portolani, Nazario
name: Prete, Francesco Paolo
name: Puzziello, Alessandro
name: Sartelli, Massimo
name: Soliani, Giorgio
name: Testini, Mario
name: Tolone, Salvatore
name: Tomasoni, Matteo
name: Tugnoli, Gregorio
name: Viale, Pierluigi
name: Zese, Monica
name: Ishay, Offir Ben
name: Kluger, Yoram
name: Kirkpatrick, Andrew
name: Ansaloni, Luca
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Elderly
Appendicitis
appendectomy
Surgery In Elderly

description: The epidemiology and the outcomes of acute appendicitis in elderly patients are very different from the younger population. Elderly patients with acute appendicitis showed higher mortality, higher perforation rate, lower diagnostic accuracy, longer delay from symptoms onset and admission, higher postoperative complication rate and higher risk of colonic and appendiceal cancer. The aim of the present work was to investigate age-related factors that could influence a different approach, compared to the 2016 WSES Jerusalem guidelines on general population, in terms of diagnosis and management of elderly patient with acute appendicitis. During the XXIX National Congress of the Italian Society of Surgical Pathophysiology (SIFIPAC) held in Cesena (Italy) in May 2019, in collaboration with the Italian Society of Geriatric Surgery (SICG), the World Society of Emergency Surgery (WSES) and the Italian Society of Emergency Medicine (SIMEU), a panel of experts participated to a Consensus Conference where eight panelists presented a number of statements, which were developed for each of the four topics about diagnosis and management of acute appendicitis in elderly patients, formulated according to the GRADE system. The statements were then voted, eventually modified and finally approved by the participants to the Consensus Conference. The current paper is reporting the definitive guidelines statements on each of the following topics: diagnosis, non-operative management, operative management and antibiotic therapy.
Antiproliferative and antibacterial activity of some glutarimide derivatives
Creators: name: Popović-Djordjević, Jelena B.
name: Klaus, Anita S.
name: Željko S. Žižak
name: Matić, Ivana Z.
name: Drakulić, Branko J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Antiproliferative and antibacterial activities of nine glutarimide derivatives (1–9) were reported. Cytotoxicity of compounds was tested toward three human cancer cell lines, HeLa, K562 and MDA-MB-453 by MTT assay. Compound 7 (2-benzyl-2-azaspiro[5.11]heptadecane-1,3,7-trione), containing 12-membered ketone ring, was found to be the most potent toward all tested cell lines (IC50 = 9–27 μM). Preliminary screening of antibacterial activity by a disk diffusion method showed that Gram-positive bacteria were more susceptible to the tested compounds than Gram-negative bacteria. Minimum inhibitory concentration (MIC) determined by a broth microdilution method confirmed that compounds 1, 2, 4, 6–8 and 9 inhibited the growth of all tested Gram-positive and some of the Gram-negative bacteria. The best antibacterial potential was achieved with compound 9 (ethyl 4-(1-benzyl-2,6-dioxopiperidin-3-yl)butanoate) against Bacillus cereus (MIC 0.625 mg/mL; 1.97 × 10−3 mol/L). Distinction between more and less active/inactive compounds was assessed from the pharmacophoric patterns obtained by molecular interaction fields.
Repulsive van der Waals Forces in Soft Matter: Why Bubbles Do Not Stick to Walls
Creators: name: Tabor, Rico F.
name: Manica, Rogerio
name: Chan, Derek
name: Grieser, Franz
name: Dagastine, Raymond R.
Publisher: name: Swinburne
Year: 2024

description: Measurements of nonequilibrium hydrodynamic interactions between bubbles and solid surfaces in water provide direct evidence that repulsive van der Waals forces of quantum origin control the behavior of liquid films on solids in air. In addition to being the simplest and most universal 3-phase system, the deformable air-water interface greatly enhances the sensitivity of force measurements compared with rigid systems. The strength of the repulsive interaction, controlled by the choice of solid, is sufficient to prevent coalescence (sticking) on separation due to hydrodynamic interactions.
Automated in situ brain imaging for mapping the Drosophila connectome
Creators: name: Chi-Wen Lin
name: Hsuan-Wen Lin
name: Mei-Tzu Chiu
name: Yung-Hsin Shih
name: Wang, Ting-Yuan
name: Hsiu-Ming Chang
name: Ann-Shyn Chiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Mapping the connectome, a wiring diagram of the entire brain, requires large-scale imaging of numerous single neurons with diverse morphology. It is a formidable challenge to reassemble these neurons into a virtual brain and correlate their structural networks with neuronal activities, which are measured in different experiments to analyze the informational flow in the brain. Here, we report an in situ brain imaging technique called Fly Head Array Slice Tomography (FHAST), which permits the reconstruction of structural and functional data to generate an integrative connectome in Drosophila. Using FHAST, the head capsules of an array of flies can be opened with a single vibratome sectioning to expose the brains, replacing the painstaking and inconsistent brain dissection process. FHAST can reveal in situ brain neuroanatomy with minimal distortion to neuronal morphology and maintain intact neuronal connections to peripheral sensory organs. Most importantly, it enables the automated 3D imaging of 100 intact fly brains in each experiment. The established head model with in situ brain neuroanatomy allows functional data to be accurately registered and associated with 3D images of single neurons. These integrative data can then be shared, searched, visualized, and analyzed for understanding how brain-wide activities in different neurons within the same circuit function together to control complex behaviors.
Automated in situ brain imaging for mapping the Drosophila connectome
Creators: name: Chi-Wen Lin
name: Hsuan-Wen Lin
name: Mei-Tzu Chiu
name: Yung-Hsin Shih
name: Wang, Ting-Yuan
name: Hsiu-Ming Chang
name: Ann-Shyn Chiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Neuroscience
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Mapping the connectome, a wiring diagram of the entire brain, requires large-scale imaging of numerous single neurons with diverse morphology. It is a formidable challenge to reassemble these neurons into a virtual brain and correlate their structural networks with neuronal activities, which are measured in different experiments to analyze the informational flow in the brain. Here, we report an in situ brain imaging technique called Fly Head Array Slice Tomography (FHAST), which permits the reconstruction of structural and functional data to generate an integrative connectome in Drosophila. Using FHAST, the head capsules of an array of flies can be opened with a single vibratome sectioning to expose the brains, replacing the painstaking and inconsistent brain dissection process. FHAST can reveal in situ brain neuroanatomy with minimal distortion to neuronal morphology and maintain intact neuronal connections to peripheral sensory organs. Most importantly, it enables the automated 3D imaging of 100 intact fly brains in each experiment. The established head model with in situ brain neuroanatomy allows functional data to be accurately registered and associated with 3D images of single neurons. These integrative data can then be shared, searched, visualized, and analyzed for understanding how brain-wide activities in different neurons within the same circuit function together to control complex behaviors.
Self, memory, and imagining the future in a case of psychogenic amnesia
Creators: name: Rathbone, Clare J.
name: Ellis, Judi A.
name: Baker, Ian
name: Butler, Chris R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Neuroscience
Developmental Biology
Science Policy

description: We report a case of psychogenic amnesia and examine the relationships between autobiographical memory impairment, the self, and ability to imagine the future. Case study JH, a 60-year-old male, experienced a 6-year period of pervasive psychogenic amnesia covering all life events from childhood to the age of 53. JH was tested during his amnesic period and again following hypnotherapy and the recovery of his memories. JH’s amnesia corresponded with deficits in self-knowledge and imagining the future. Results are discussed with reference to models of self and memory and processes involving remembering and imagining.
Bangana dero
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Bangana
Bangana dero

description: 77. Bangana dero (Hamilton, 1822)
Common name. Kalabans
Taxonomy. Original description: Cyprinus dero Hamilton, 1822: 277, 385, pl. 22 (fig. 78) [Brahmaputra River, at Gualpara (Goalpara), Assam, India; no types known].
Revisions. Zhang & Chen (2006: 50).
Illustrations. Hamilton (1822: pl. 22, fig. 78) as Cyprinus dero.
Distribution in Iran. —Distribution in River Basin: Hamun-e Mashkid.—Distribution in Ecoregions: 701- Baluchistan.
Status in Iran. [Exotic].—Kalabans.—First reported from Iran by Esmaeili et al. (2013a); Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).— Iran material: ZM-CBSU.
Conservation. Not relevant (introduced species).
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on pages 30-31, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Creators: name: Demircioglu, Fevzi
name: Wang, Jun
name: Candido, Juliana
name: Costa, Ana S H
name: Casado, Pedro
name: De Luxan Delgado, Beatriz
name: Reynolds, Louise E
name: Gomez-Escudero, Jesus
name: Newport, Emma
name: Rajeeve, Vinothini
name: Baker, Ann-Marie
name: Roy-Luzarraga, Marina
name: Graham, Trevor A
name: Foster, Julie
name: Wang, Yu
name: Campbell, James J
name: Singh, Rajinder
name: Zhang, Penglie
name: Schall, Thomas J
name: Balkwill, Frances R
name: Sosabowski, Jane
name: Cutillas, Pedro R
name: Frezza, Christian
name: Sancho, Patricia
name: Hodivala-Dilke, Kairbaan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through pathways under the control of FAK. In breast and pancreatic cancer patients we find that low FAK expression, specifically in the stromal compartment, predicts reduced overall survival. In mice, depletion of FAK in a subpopulation of CAFs regulates paracrine signals that increase malignant cell glycolysis and tumour growth. Proteomic and phosphoproteomic analysis in our mouse model identifies metabolic alterations which are reflected at the transcriptomic level in patients with low stromal FAK. Mechanistically we demonstrate that FAK-depletion in CAFs increases chemokine production, which via CCR1/CCR2 on cancer cells, activate protein kinase A, leading to enhanced malignant cell glycolysis. Our data uncover mechanisms whereby stromal fibroblasts regulate cancer cell metabolism independent of genetic mutations in cancer cells.
Truck Crop Production Practices Berrien and Van Buren Counties, Michigan: Labor, Power, and Materials, by Operation
Creators: name: Gavett, Earle E.
name: Gavett, Earle E.
Publisher: name: Unknown
Year: 1965
Subjects: Crop Production/Industries
Labor and Human Capital
Production Economics

description: Excerpts from the report: In 1963 U. S. production of truck crops for fresh market and processing occupied 3.3 million acres of cropland. These crops used slightly more than 1 percent of the total cropland. The farm value of truck crops harvested for sale exceeded $1. 2 billion, or an average of $361 per acre harvested. This is the 11th in a group of 12 publications containing information on labor requirements, production practices, and costs involved in the production of truck crops for fresh market and processing. Information in this report was obtained from 346 producers in Berrien and Van Buren Counties, Mich.
description: Covers the following truck crops for fresh market: Asparagus (Non-Producing Beds), Asparagus (Producing Beds), Cantaloups, Sweet Corn, Cucumbers, Tomatoes, Strawberries (New Beds), and Strawberries (Producing Beds). Covers the following truck crops for processing: Asparagus, Cucumbers, and Tomatoes.
DEVELOPMENT OF ENGLISH-SPEAKING SKILLS OF MEDICAL ACADEMIC LYCEUM STUDENTS THROUGH INTERACTIVE METHODS
Creators: name: Turaeva, Nilufar
Publisher: name: Zenodo
Year: 2025

description: In today’s globalized world, proficiency in English is increasingly vital, especially in the medical field where communication is key to effective patient care and collaboration among healthcare professionals. For students in medical academic lyceums, developing strong English-speaking skills not only enhances their academic performance but also prepares them for future careers in an international environment. This article explores various interactive methods that can be employed to foster the development of English-speaking skills among medical students, emphasizing the importance of engagement, collaboration, and practical application.
Drag reduction by leidenfrost vapor layers
Creators: name: Vakarelski, Ivan U.
name: Marston, Jeremy O.
name: Chan, Derek
name: Thoroddsen, Sigurdur T.
Publisher: name: Swinburne
Year: 2024

description: We demonstrate and quantify a highly effective drag reduction technique that exploits the Leidenfrost effect to create a continuous and robust lubricating vapor layer on the surface of a heated solid sphere moving in a liquid. Using high-speed video, we show that such vapor layers can reduce the hydrodynamic drag by over 85%. These results appear to approach the ultimate limit of drag reduction possible by different methods based on gas-layer lubrication and can stimulate the development of related energy saving technologies.
Non-singular boundary integral methods for fluid mechanics applications
Creators: name: Klaseboer, Evert
name: Sun, Qiang
name: Chan, Derek
Publisher: name: Swinburne
Year: 2024

description: A formulation of the boundary integral method for solving partial differential equations has been developed whereby the usual weakly singular integral and the Cauchy principal value integral can be removed analytically. The broad applicability of the approach is illustrated with a number of problems of practical interest to fluid and continuum mechanics including the solution of the Laplace equation for potential flow, the Helmholtz equation as well as the equations for Stokes flow and linear elasticity.
Spatiotemporal Evolution of Thin Liquid Films during Impact of Water Bubbles on Glass on a Micrometer to Nanometer Scale
Creators: name: Hendrix, Maurice H. W.
name: Manica, Rogerio
name: Klaseboer, Evert
name: Chan, Derek
name: Ohl, Claus-Dieter
Publisher: name: Swinburne
Year: 2024

description: Collisions between millimeter-size bubbles in water against a glass plate are studied using high-speed video. Bubble trajectory and shape are tracked simultaneously with laser interferometry between the glass and bubble surfaces that monitors spatial-temporal evolution of the trapped water film. Initial bubble bounces and the final attachment of the bubble to the surface have been quantified. While the global Reynolds number is large (∼102), the film Reynolds number remains small and permits analysis with lubrication theory with tangentially immobile boundary condition at the air-water interface. Accurate predictions of dimple formation and subsequent film drainage are obtained.
Retrieval-Extinction and Relapse Prevention: Rewriting Maladaptive Drug Memories?
Creators: name: Kuijer, Eloise J
name: Ferragud, Antonio
name: Milton, Amy L
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Rat
Extinction
Addiction
Memory Reconsolidation
Retrieval-extinction

description: Addicted individuals are highly susceptible to relapse when exposed to drug-associated conditioned stimuli (CSs; "drug cues") even after extensive periods of abstinence. Until recently, these maladaptive emotional drug memories were believed to be permanent and resistant to change. The rediscovery of the phenomenon of memory reconsolidation-by which retrieval of the memory can, under certain conditions, destabilize the previously stable memory before it restabilizes in its new, updated form-has led to the hypothesis that it may be possible to disrupt the strong maladaptive drug-memories that trigger a relapse. Furthermore, recent work has suggested that extinction training "within the reconsolidation window" may lead to a long-term reduction in relapse without the requirement for pharmacological amnestic agents. However, this so-called "retrieval-extinction" effect has been inconsistently observed in the literature, leading some to speculate that rather than reflecting memory updating, it may be the product of facilitation of extinction. In this mini review article, we will focus on factors that might be responsible for the retrieval-extinction effects on preventing drug-seeking relapse and how inter-individual differences may influence this therapeutically promising effect. A better understanding of the psychological and neurobiological mechanisms underpinning the "retrieval-extinction" paradigm, and individual differences in boundary conditions, should provide insights with the potential to optimize the translation of "retrieval-extinction" to clinical populations.
Adherence to NICE guidance on glucagon-like peptide-1 receptor agonists among patients with type 2 diabetes mellitus: an evaluation using the Clinical Practice Research Datalink
Creators: name: Jameson, Kevin
name: D’Oca, Kalpana
name: Leigh, Paul
name: Tarita Murray-Thomas
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Cell Biology
subject: Medicine

description: Aims:To assess adherence to the UK’s National Institute for Health and Care Excellence (NICE) guidelines for initiating and continuing glucagon-like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes (T2DM).Research design and methods:A retrospective cohort study of 7133 primary care patients ≥40 years with a first prescription for a GLP-1 receptor agonist following publication of NICE guideline/guidance. Patient characteristics and levels of clinical monitoring were assessed using descriptive analyses.Main outcome measures:Main outcomes were the proportion of patients initiating GLP-1 receptor agonists as part of NICE-recommended dual- or triple-therapy regimens; the proportions meeting NICE triple therapy initiation criteria (glycosylated hemoglobin [HbA1c] ≥7.5% and body mass index [BMI] ≥35 kg/m2) and the proportions continuing GLP-1 receptor agonist at 6 months according to NICE recommendations.Results:Mean age at initiating GLP-1 receptor agonists was 58.2 years (SD 9.4), BMI 38.4 kg/m2 (SD 6.8) and HbA1c 9.2% (SD 3.2%). Overall, only 25% of patients initiated GLP-1 receptor agonists as part of a NICE-recommended regimen. Of patients initiated on a recommended triple-therapy regimen, 50% (646/1284) fulfilled both NICE HbA1c and BMI initiation criteria. Approximately 18% (32/174) of patients continuing NICE-recommended dual therapy at 6 months achieved a 1% reduction in HbA1c and 6.4% (33/515) continuing with NICE-recommended triple therapy achieved NICE’s target reductions for both HbA1c and body weight. About 8% of patients continuing exenatide as triple therapy (N = 243) achieved both targets.Conclusions:Adherence to NICE guidance for initiating and continuing GLP-1 receptor agonists is low. However, lack of data on ethnicity (for assessing NICE’s BMI criteria) and on contraindications and/or hypersensitivity to other diabetes medication in the treatment pathway have limited our ability to fully assess adherence to GLP-1 prescribing. Further research is warranted to better understand general practitioners’ prescribing decisions given the cost of prescribing GLP-1 receptor agonists.
Deep-inspiration breath-hold 18F-FDG-PET/CT is useful for assessment of connective tissue disease associated interstitial pneumonia
Creators: name: Takeno, Mitsuhiro
name: Suda, Akiko
name: Ihata, Atsushi
name: Ueda, Atsuhisa
name: Ishigatsubo, Yoshiaki
name: Uehara, Takeaki
name: Maasa Hama
name: Yoshimi, Ryusuke
name: Ukihide Tateishi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Objective: To examine clinical utility of 18F-flurodeoxyglucose (FDG)-positron emission tomography (PET)/CT for assessment of interstitial lung disease (ILD) in patients with connective tissue diseases (CTDs).Methods: A total of 69 18F-FDG PET/CT scans were conducted under deep inspiratory breath hold (DIBH) conditions in 45 CTD patients with ILD, including 16 dermatomyositis/polymyositis, nine systemic scleroderma and seven rheumatoid arthritis. Intensity and distribution of 18F-FDG signals in PET/CT were determined by standardized uptake value (SUVmax) and visual score in 18 regions, respectively. ILD was defined as active when immunosuppressive therapy was initiated or intensified.Results: Both SUVmax and visual score were higher in active phase (n = 32) than inactive phase (n = 37) (both p r2 = 0.38, p r2 = 0.52, p Conclusion: The DIBH 18F-FDG PET/CT procedure sensitively illustrates active ILD lesions in CTD and the extended signal distribution is associated with unfavorable clinical outcome.
Garra amirhosseini Esmaeili, Sayyadzadeh, Coad & Eagderi 2016
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Garra
Garra amirhosseini

description: 78. Garra amirhosseini Esmaeili, Sayyadzadeh, Coad & Eagderi, 2016
Common name. Amirhossein’s garra
Taxonomy. Original description: Garra amirhosseini Esmaeili, Sayyadzadeh, Coad & Eagderi, 2016: 87, figs. 2-10 [Sartang-e-Bijar hot spring at Mehran, Tigris River drainage, Ilam Province, Iran, 33°46'16.3''N, 45°56'17.2''E; holotype: ZM-CBSU H1216].
Revisions. None.
Illustrations. Esmaeili et al. (2016a: 87, fig. 2).
Distribution in Iran. —Distribution in River Basin: Tigris.—Distribution in Ecoregions: 441-Lower Tigris & Euphrates.
Status in Iran. [Endemic].—Gel cheragh-e Amirhossein.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 31, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons.
Creators: name: Sybirna, Anastasiya
name: Tang, Walfred W C
name: Pierson Smela, Merrick
name: Dietmann, Sabine
name: Gruhn, Wolfram H
name: Brosh, Ran
name: Surani, M Azim
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory network of human PGCs (hPGCs) remains unclear. Besides, a previous knockdown study indicated that PRDM14 might be dispensable for human germ cell fate. Here, we decided to use inducible degrons for a more rapid and comprehensive PRDM14 depletion. We show that PRDM14 loss results in significantly reduced specification efficiency and an aberrant transcriptome of hPGC-like cells (hPGCLCs) obtained in vitro from human embryonic stem cells (hESCs). Chromatin immunoprecipitation and transcriptomic analyses suggest that PRDM14 cooperates with TFAP2C and BLIMP1 to upregulate germ cell and pluripotency genes, while repressing WNT signalling and somatic markers. Notably, PRDM14 targets are not conserved between mouse and human, emphasising the divergent molecular mechanisms of PGC specification. The effectiveness of degrons for acute protein depletion is widely applicable in various developmental contexts.
Criterion validity of two physical activity and one sedentary time questionnaire against accelerometry in a large cohort of adults and older adults.
Creators: name: Sagelv, Edvard H
name: Hopstock, Laila A
name: Johansson, Jonas
name: Hansen, Bjørge H
name: Brage, Soren
name: Horsch, Alexander
name: Ekelund, Ulf
name: Morseth, Bente
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Medicine
epidemiology
Physical Activity
Accelerometer
Sitting Time

description: Objectives:We compared the ability of physical activity and sitting time questionnaires (PAQ) for ranking individuals versus continuous volume calculations (physical activity level (PAL), metabolic equivalents of task (MET), sitting hours) against accelerometry measured physical activity as our criterion. Methods:Participants in a cohort from the Tromsø Study completed three questionnaires; (1) The Saltin-Grimby Physical Activity Level Scale (SGPALS) (n=4040); (2) The Physical Activity Frequency, Intensity and Duration (PAFID) questionnaire (n=5902)) calculated as MET-hours·week-1 and (3) The International Physical Activity questionnaire (IPAQ) short-form sitting question (n=4896). We validated the questionnaires against the following accelerometry (Actigraph wGT3X-BT) estimates: vector magnitude counts per minute, steps∙day-1, time (minutes·day-1) in sedentary behaviour, light physical activity, moderate and vigorous physical activity (MVPA) non-bouted and ≥10 min bouted MVPA. Results:Ranking of physical activity according to the SGPALS and quartiles (Q) of MET-hours∙week-1 from the PAFID were both positively associated with accelerometry estimates of physical activity (p<0.001) but correlations with accelerometry estimates were weak (SGPALS (PAL): r=0.11 to 0.26, p<0.001) and weak-to-moderate (PAFID: r=0.39 to 0.44, p<0.01). There was 1 hour of accelerometry measured sedentary time from Q1 to Q4 in the IPAQ sitting question (p<0.001) and also weak correlations (r=0.22, p<0.01). Conclusion:Ranking of physical activity levels measured with PAQs appears to have higher validity than energy expenditure calculations. Self-reported sedentary time poorly reflects accelerometry measured sedentary time. These two PAQs can be used for ranking individuals into different physical activity categories supporting previous studies using these instruments when assessing associations with health outcomes.
Gendered (s)explorations among same-sex attracted young people in Australia
Creators: name: Dempsey, Deborah
name: HILLIER, LYNNE
name: HARRISON, LYN
Publisher: name: Swinburne
Year: 2024

description: This paper seeks to import a more complex understanding of gendered subjectivity into discussions of young people and homosexuality, and is based on an Australian national survey (n=749) of same-sex attracted youth (SSAY) aged between 14 and 21. Results revealed significant gender differences with regard to patterns of sexual attraction, behaviour and identity labels among participants. For the young men in the study, there was more congruence between feelings of gender a-typicality, same-sex attractions and same-sex behaviours. Overall, young women displayed more fluidity with regard to their sexual feelings, behaviours and identities. Young women were more likely to be engaged in private explorations of lesbianism, concurrent with participation in heterosexual sex and relationships. Young women were also grappling with more limited and emotionally risky opportunities for sex with other girls who were already known to them as friends. The invisibility of lesbianism as an identity or practice led to confusion about what feelings meant for the future in the arena of lived experience. The paper concludes that more research is needed into the impact of gender on the development of young people's experiences of homosexuality, particularly the manner in which invisibility and lack of social acceptance of a full spectrum of sexual diversity may disadvantage young women's emotional health and well-being.
TEACHERS' BELIEF TOWARDS THE IMPLEMENTATION OF ICT IN INTERMEDIATE SCHOOLS IN SAUDI ARABIA
Creators: name: Jaber Almarri, Rabiatul Adawiah Ahmad Rashid
Publisher: name: TuEngr Group
Year: 2020
Subjects: ICT implementation
ICT classroom
Technology-based teaching
ICT school
ICT integrated learning.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 4, 11A04M: 1-10