cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supplemental Information from Elucidating the signal for contact guidance contained in aligned fibrils with a microstructural-mechanical model
Creators: name: Bersie-Larson, Lauren M.
name: Lai, Victor K.
name: Dhume, Rohit Y.
name: Provenzano, Paolo P.
name: Barocas, Victor H.
name: Tranquillo, Robert T.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: Despite its importance in physiological processes and tissue engineering, the mechanism underlying cell contact guidance in an aligned fibrillar network has defied elucidation due to multiple interdependent signals that such a network presents to cells, namely, anisotropy of adhesion, porosity and mechanical behaviour. A microstructural-mechanical model of fibril networks was used to assess the relative magnitudes of these competing signals in networks of varied alignment strength based on idealized cylindrical pseudopods projected into the aligned and orthogonal directions and computing the anisotropy of metrics chosen for adhesion, porosity and mechanical behaviour: cylinder-fibre contact area for adhesion, persistence length of pores for porosity and total force to displace fibres from the cylindrical volume as well as network stiffness experienced upon cylinder retraction for mechanical behaviour. The signals related to mechanical anisotropy are substantially higher than adhesion and porosity anisotropy, especially at stronger network alignments, although their signal to noise (S/N) values are substantially lower. The former finding is consistent with a recent report that fibroblasts can sense fibril alignment via anisotropy of network mechanical resistance, and the model reveals this can be due to either mechanical resistance to pseudopod protrusion or retraction given their signal and S/N values are similar.
Time Boxing Template
Creators: name: Palanisamy, Gobinath
Publisher: name: Zenodo
Year: 2024
Subjects: customer success
time boxing

description: This is time boxing template I customised it for for Customer Success Managers who works on geospatial field. This document is free to use, modify and shared under Creative Commons Attribution Non Commercial 4.0 International so please do not sell this for earning money.
Arc magmatic evolution and the construction of continental crust at the Central American Volcanic Arc system
Creators: name: Stern, Robert J.
name: Whattam, Scott A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Physiology
subject: Genetics
subject: Medicine

description: ABSTRACTWhether or not magmatic arcs evolve compositionally with time and the processes responsible remain controversial. Resolution of this question requires the reconstruction of arc geochemical evolution at the level of a discrete arc system. Here, we address this problem using the well-studied Central American Volcanic Arc System (CAVAS) as an example. Geochemical and isotopic data were compiled for 1031 samples of lavas and intrusive rocks from the ~1100 km-long segment of oceanic CAVAS (Panama, Costa Rica, Nicaragua) built on thickened oceanic crust over its 75 million year lifespan. We used available age constraints to subdivide this data set into six magmatic phases: 75–39 Ma (Phase I or PI); 35–16 Ma (PII); 16–6 Ma (PIII); 6–3 Ma (PIV); 5.9–0.01 Ma (PVa arc alkaline and PVb adakitic); and 2.6–0 Ma (PVI, Quaternary to modern magmatism, predominantly ≪ 1 Ma). To correct for magmatic fractionation, selected major and trace element abundances were linearly regressed to 55 wt.% SiO2. The most striking observation is the overall evolution of the CAVAS to more incompatible element enriched and ultimately continental-like compositions with time, although magmatic evolution took on a more regional character in the youngest rocks, with magmatic rocks of Nicaragua becoming increasingly distinguishable from those of Costa Rica and Panama with time. Models entailing progressive arc magmatic enrichment are generally supported by the CAVAS record. Progressive enrichment of the oceanic CAVAS with time reflects changes in mantle wedge composition and decreased melting due to arc crust thickening, which was kick-started by the involvement of enriched plume mantle in the formation of the CAVAS. Progressive crustal thickening and associated changes in the sub-arc thermal regime resulted in decreasing degrees of partial melting over time, which allowed for progressive enrichment of the CAVAS and ultimately the production of continental-like crust in Panama and Costa Rica by ~16–10 Ma.
Synthesis by ring closing metathesis and properties of an electroactive calix[6]arene [2]catenane
Creators: name: Orlandini, Guido
name: Zanichelli, Valeria
name: Secchi, Andrea
name: Arduini, Arturo
name: Ragazzon, Giulio
name: Credi, Alberto
name: Venturi, Margherita
name: Silvi, Serena
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Tris-(N-phenylureido)-calix[6]arenes are heteroditopic non-symmetric molecular wheels that, in apolar media, bind viologen-based molecular axles in a pseudorotaxane-type fashion. Because of the precise kinetic requirements associated with the threading process, in apolar solvents, the dicationic portion of the axle enters the calixarene annulus exclusively from the upper rim. With the general aim to develop new prototypes of molecular devices and machines whose functions could be governed through a wider set of control elements, we envisaged that the unique properties of these calixarene wheels could be transferred to the synthesis of new catenanes for the construction of unidirectional rotary motors. Herein, we describe the synthesis of a tris(N-phenylureido)calix[6]arene-based catenane by applying the intramolecular ring-closing metathesis reaction for the catenation step on a pre-formed pseudorotaxane.
Syntheses, crystal structures, magnetic and luminescent properties of lanthanide complexes with nitronyl nitroxide radical as ligand
Creators: name: Wang, Shi-Yu
name: Wang, Wen-Min
name: Quan, Ying-Ping
name: Gao, Hong-Ling
name: Cui, Jian-Zhong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: Four lanthanide-nitronyl nitroxide radical complexes, [Ln(hfac)3(NIT-3Methien)2] (Ln = Pr (1), Tb (2), Dy (3), Ho (4); hfac = hexafluoroacetylacetonate; NIT-3Methien = 2-(3-methylthiophene)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide), have been synthesized, and structurally and magnetically characterized. Single-crystal X-ray diffraction shows that 1–4 have similar mononuclear tri-spin structures in which central Ln(III) ions are eight coordinate by two NIT-3Methien radicals and three hfac coligands. The magnetic studies indicate that there are antiferromagnetic interactions between Ln(III) ions and radicals in 1, 2, and 4, while ferromagnetic interactions are present in 3. The luminescence properties of 2 and 3 were studied.
In vitro antioxidant, antifungal and antibacterial activities of five international Calibrachoa cultivars
Creators: name: Hosam O. Elansary
name: Kowiyou Yessoufou
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: The total phenolic, flavonoid and tannin contents in leaf extracts of Calibrachoa x hybrida (C.h.) (Solanaceae) international cultivars, as well as their overall antioxidant activities using DPPH and linoleic acid assays, were investigated. Furthermore, the antifungal and the antibacterial activities were examined against a wide spectrum of micro-organisms. DPPH and linoleic acid assays ranged from 62.1 to 80.1% and of 74.1–93.4%, respectively. C.h. Superbells® Trailing Rose (CHST), C.h. Superbells® Frost Fire, C.h. Superbells® Strawberry Punch, C.h. Superbells® Dreamsicle and C.h. Superbells® Plum (CHSP) varied in their antifungal and the antibacterial activities against a wide spectrum of micro-organisms. CHSP exhibited the highest antioxidant, antifungal and antibacterial activities followed by CHST. These activities might be attributed to the presence of phenolic, flavonoid and tannin compounds, indicating that these cultivars might be potential sources of therapeutic substances.
A review on biological sources, chemistry and pharmacological activities of pinostrobin
Creators: name: Patel, Neeraj K.
name: Gaurav Jaiswal
name: Bhutani, Kamlesh K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Science Policy

description: Pinostrobin, a dietary bioflavonoid discovered more than 6 decades ago in the heart-wood of pine (Pinus strobus), has depicted many pharmacological activities including anti-viral, anti-oxidant, anti-leukaemic, anti-inflammatory and anti-aromatase activities. It is an inhibitor of sodium channel and Ca2+ signalling pathways and also inhibits intestinal smooth muscle contractions. In spite of the fact that pinostrobin has an application as functional foods, till-to-date no comprehensive review on pinostrobin has been carried out. Hence, the present review deals with the biological sources, chemistry and pharmacological activities of pinostrobin.
Syntheses, crystal structures, magnetic and luminescent properties of lanthanide complexes with nitronyl nitroxide radical as ligand
Creators: name: Wang, Shi-Yu
name: Wang, Wen-Min
name: Quan, Ying-Ping
name: Gao, Hong-Ling
name: Cui, Jian-Zhong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: Four lanthanide-nitronyl nitroxide radical complexes, [Ln(hfac)3(NIT-3Methien)2] (Ln = Pr (1), Tb (2), Dy (3), Ho (4); hfac = hexafluoroacetylacetonate; NIT-3Methien = 2-(3-methylthiophene)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide), have been synthesized, and structurally and magnetically characterized. Single-crystal X-ray diffraction shows that 1–4 have similar mononuclear tri-spin structures in which central Ln(III) ions are eight coordinate by two NIT-3Methien radicals and three hfac coligands. The magnetic studies indicate that there are antiferromagnetic interactions between Ln(III) ions and radicals in 1, 2, and 4, while ferromagnetic interactions are present in 3. The luminescence properties of 2 and 3 were studied.
MLTC Symposium 2024 - Introduction to the AIM RSF
Creators: name: Ambrose, Sydney
Publisher: name: Zenodo
Year: 2024

description: Presentation delivered at the MLTC Symposium for Analysis of Multimorbidity Research on 28th and 29th October 2024.

This covered an introduction to the AI for Multiple Long-Term Conditions Research Support Facilitity. The presentation was titled "Challenges and Solutions for AI & MLTC Research: the AIM RSF approach".
Wissenschaftliche Begründung für die Empfehlung zur Impfung gegen Japanische Enzephalitis bei Reisen in Endemiegebiete und für Laborpersonal
Creators: name: Kling, Kerstin
name: Bogdan, Christian
name: Burchard, Gerd
name: Harder, Thomas
name: Von Kries, Rüdiger
name: Ledig, Thomas
name: Löscher, Thomas
name: Mertens, Thomas
name: Rieke, Burkhard
name: Röbl-Matthieu, Marianne
name: Schmitt-Chanasit, Jonas
name: Wichmann, Ole
name: Wiedermann, Ursula
Publisher: name: Robert Koch-Institut
Year: 2020
Subjects: subject: STIKO
subject: Reiseimpfung
subject: Japanische Enzephalitis
subject: Flavivirus
subject: 610 Medizin und Gesundheit

description: Die STIKO empfiehlt im Epidemiologischen Bulletin 18/2020 die Impfung gegen Japanische Enzephalitis als Reiseimpfung für alle Reisenden bei Aufenthalten in entsprechenden Verbreitungsgebieten unter bestimmten Bedingungen und als beruflich indizierte Impfung für Laborpersonal, das gezielt mit vermehrungsfähigen Japanische-Enzephalitis-Virus-Wildtypstämmen arbeitet. In Deutschland ist derzeit nur ein inaktivierter Ganzvirusimpfstoff zugelassen.
Cardiopulmonary bypass machines (Medical illustrations, Drawings)
Creators: name: Francone, Clarice Ashworth
Publisher: name: Oregon Health & Science University
Year: 0
Subjects: Medical Illustration
Heart-Lung Machine
Cardiopulmonary Bypass

description: Three labeled drawings detailing the workings of cardiopulmonary bypass machines, used to keep patients alive during surgeries which prevent normal function of the heart and lungs.
Supplementary Information from Sideward contact tracing and the control of epidemics in large gatherings
Creators: name: Mancastroppa, Marco
name: Guizzo, Andrea
name: Castellano, Claudio
name: Vezzani, Alessandro
name: Burioni, Raffaella
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Derivation of analytical results, data description
Fetuses & Fallopian Tubes (Medical illustrations, Drawings)
Creators: name: Francone, Clarice Ashworth
Publisher: name: Oregon Health & Science University
Year: 0
Subjects: Medical Illustration
Ovarian Cysts
Fetus
Fallopian Tubes
Pregnancy
Gynecologic Surgical Procedures

description: Highly detailed mounted drawings depicting fetuses, ovarian cysts and surgeries on the female reproductive system. Items include written descriptive information on the front, back or both.
Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4
Creators: name: Malak, Peter N
name: Dannenmann, Benjamin
name: Hirth, Alexander
name: Rothfuss, Oliver C
name: Schulze-Osthoff, Klaus
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: The four OSKM factors OCT4, SOX2, KLF4 and c-MYC are key transcription factors modulating pluripotency, self-renewal and tumorigenesis in stem cells. However, although their transcriptional targets have been extensively studied, little is known about how these factors are regulated at the posttranslational level. In this study, we established an in vitro system to identify phosphorylation patterns of the OSKM factors by AKT kinase. OCT4, SOX2, KLF4 and c-MYC were expressed in Sf9 insect cells employing the baculoviral expression system. OCT4, SOX2 and KLF4 were localized in the nucleus of insect cells, allowing their easy purification to near homogeneity upon nuclear fractionation. All transcription factors were isolated as biologically active DNA-binding proteins. Using in vitro phosphorylation and mass spectrometry-based phosphoproteome analyses several novel and known AKT phosphorylation sites could be identified in OCT4, SOX2 and KLF4.
SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status
Creators: name: M Gordian Adam
name: Matt, Sonja
name: Christian, Sven
name: Hess-Stumpp, Holger
name: Haegebarth, Andrea
name: Hofmann, Thomas G
name: Algire, Carolyn
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Seven-in-absentia homolog (SIAH) proteins are evolutionary conserved RING type E3 ubiquitin ligases responsible for the degradation of key molecules regulating DNA damage response, hypoxic adaptation, apoptosis, angiogenesis, and cell proliferation. Many studies suggest a tumorigenic role for SIAH2. In breast cancer patients SIAH2 expression levels correlate with cancer aggressiveness and overall patient survival. In addition, SIAH inhibition reduced metastasis in melanoma. The role of SIAH1 in breast cancer is still ambiguous; both tumorigenic and tumor suppressive functions have been reported. Other studies categorized SIAH ligases as either pro- or antimigratory, while the significance for metastasis is largely unknown. Here, we re-evaluated the effects of SIAH1 and SIAH2 depletion in breast cancer cell lines, focusing on migration and invasion. We successfully knocked down SIAH1 and SIAH2 in several breast cancer cell lines. In luminal type MCF7 cells, this led to stabilization of the SIAH substrate Prolyl Hydroxylase Domain protein 3 (PHD3) and reduced Hypoxia-Inducible Factor 1α (HIF1α) protein levels. Both the knockdown of SIAH1 or SIAH2 led to increased apoptosis and reduced proliferation, with comparable effects. These results point to a tumor promoting role for SIAH1 in breast cancer similar to SIAH2. In addition, depletion of SIAH1 or SIAH2 also led to decreased cell migration and invasion in breast cancer cells. SIAH knockdown also controlled microtubule dynamics by markedly decreasing the protein levels of stathmin, most likely via p27Kip1. Collectively, these results suggest that both SIAH ligases promote a migratory cancer cell phenotype and could contribute to metastasis in breast cancer.
The Effect of Inkjet Operating Parameters on the Size Control of Aerosol Particles
Creators: name: Shin, Woo Jin
name: Jeong, Young-Su
name: Kibong Choi
name: Shin, Weon Gyu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: We investigated the effect of inkjet operating parameters on the size control of aerosol particles. Droplets with agglomerates of polystyrene latex particles were generated from an inkjet nozzle and continuously dried up at the temperature of 38°C. When droplets have the size range of 30 to 70 μm in diameter, aerosol particles with the size range of 3.5 to 7.1 μm were generated after the drying process. We controlled the particle size easily within a factor of two by adjusting rising/falling time and voltages of an actuating waveform. Generated particles were shown to have a narrow particle size distribution. Thus, the particle concentration of aqueous suspension does not need to be adjusted precisely in order to control the size of generated aerosol particles. Copyright © 2015 American Association for Aerosol Research
Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4
Creators: name: Schulze-Osthoff, Klaus
name: Malak, Peter N
name: Dannenmann, Benjamin
name: Hirth, Alexander
name: Rothfuss, Oliver C
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: The four OSKM factors OCT4, SOX2, KLF4 and c-MYC are key transcription factors modulating pluripotency, self-renewal and tumorigenesis in stem cells. However, although their transcriptional targets have been extensively studied, little is known about how these factors are regulated at the posttranslational level. In this study, we established an in vitro system to identify phosphorylation patterns of the OSKM factors by AKT kinase. OCT4, SOX2, KLF4 and c-MYC were expressed in Sf9 insect cells employing the baculoviral expression system. OCT4, SOX2 and KLF4 were localized in the nucleus of insect cells, allowing their easy purification to near homogeneity upon nuclear fractionation. All transcription factors were isolated as biologically active DNA-binding proteins. Using in vitro phosphorylation and mass spectrometry-based phosphoproteome analyses several novel and known AKT phosphorylation sites could be identified in OCT4, SOX2 and KLF4.
Supplementary information from Polysaccharide metabolism regulates structural colour in bacterial colonies
Creators: name: van de Kerkhof, Gea T
name: Schertel, Lukas
name: Catòn, Laura
name: Parton, Thomas G
name: Müller, Karin H
name: Greer, Heather F
name: Ingham, Colin J
name: Vignolini, Silvia
Publisher: name: The Royal Society
Year: 2022
Subjects: Biophysics
Biochemistry

description: All the supplementary figures and tables as have been referred to in the manuscript.
Six-year course and prognosis of traumatic knee symptoms in general practice: Cohort study
Creators: name: Kastelein, Marlous
name: Luijsterburg, Pim A. J.
name: Verhaar, Jan A. N.
name: Koes, Bart W.
name: Bierma-Zeinstra, Sita M. A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Background Traumatic knee symptoms are frequently seen, however, evidence about the course and prognostic factors are scarce. Objectives To describe the one and six-year course of traumatic knee symptoms presenting in general practice, and to identify prognostic factors for persistent knee symptoms. Methods Adolescents (≥12 years) and adults with traumatic knee symptoms (n = 328) from general practice were followed for six years with self-report questionnaires and physical examination. Results Persistent knee symptoms were reported by 27% of the patients at one year and by 33% at six years. There was a strong relationship (OR: 11.0, 95% CI: 5.0–24.2) between having persistent knee symptoms at one year and at six-year follow-up. Prognostic factors associated with persistent knee symptoms at one year were age, poor general health, history of non-traumatic knee symptoms, absence floating patella and laxity on the anterior drawer test (AUC: 0.72). At six-year follow-up, age, body mass index > 27, non-skeletal co-morbidity, self-reported crepitus of the knee, history of non-traumatic knee symptoms, and laxity on the anterior drawer test were associated with persistent knee symptoms (AUC: 0.82). Conclusion Traumatic knee symptoms in general practice seem to become a chronic disorder in one out of three patients. Several prognostic factors assessed at baseline were associated with persistent knee symptoms at one and six-year follow-up.
Six-year course and prognosis of traumatic knee symptoms in general practice: Cohort study
Creators: name: Kastelein, Marlous
name: Luijsterburg, Pim A. J.
name: Verhaar, Jan A. N.
name: Koes, Bart W.
name: Bierma-Zeinstra, Sita M. A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Background Traumatic knee symptoms are frequently seen, however, evidence about the course and prognostic factors are scarce. Objectives To describe the one and six-year course of traumatic knee symptoms presenting in general practice, and to identify prognostic factors for persistent knee symptoms. Methods Adolescents (≥12 years) and adults with traumatic knee symptoms (n = 328) from general practice were followed for six years with self-report questionnaires and physical examination. Results Persistent knee symptoms were reported by 27% of the patients at one year and by 33% at six years. There was a strong relationship (OR: 11.0, 95% CI: 5.0–24.2) between having persistent knee symptoms at one year and at six-year follow-up. Prognostic factors associated with persistent knee symptoms at one year were age, poor general health, history of non-traumatic knee symptoms, absence floating patella and laxity on the anterior drawer test (AUC: 0.72). At six-year follow-up, age, body mass index > 27, non-skeletal co-morbidity, self-reported crepitus of the knee, history of non-traumatic knee symptoms, and laxity on the anterior drawer test were associated with persistent knee symptoms (AUC: 0.82). Conclusion Traumatic knee symptoms in general practice seem to become a chronic disorder in one out of three patients. Several prognostic factors assessed at baseline were associated with persistent knee symptoms at one and six-year follow-up.
“Fury, us”: Anger as a basis for new group self-categories
Creators: name: Livingstone, Andrew G.
name: Shepherd, Lee
name: Spears, Russell
name: Manstead, Antony S. R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: We tested the hypothesis that shared emotions, notably anger, influence the formation of new self-categories. We first measured participants' (N = 89) emotional reactions to a proposal to make university assessment tougher before providing feedback about the reactions of eight other co-present individuals. This feedback always contained information about the other individuals' attitudes to the proposals (four opposed and four not opposed) and in the experimental condition emotion information (of those opposed, two were angry, two were sad). Participants self-categorised more with, and preferred to work with, angry rather than sad targets, but only when participants' own anger was high. These findings support the idea that emotions are a potent determinant of self-categorisation, even in the absence of existing, available self-categories.
Emotions are not always contagious: Longitudinal spreading of self-pride and group pride in homogeneous and status-differentiated groups
Creators: name: Batja Mesquita
name: Delvaux, Ellen
name: Meeussen, Loes
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Developmental Biology
Biological Sciences
Earth and Environmental Sciences

description: The members of task groups are emotionally more similar to each other than to others outside the group; yet, little is known about the conditions under which this emotional similarity emerges. In two longitudinal studies, we tested the idea that emotions only spread when they contain information that is relevant to all group members. We compared the spreading of group pride (relevant) with self-pride (not relevant). The first study followed emotions in 68 task groups (N = 295) across 4 moments. Multilevel cross-lagged path analyses showed that group members mutually influenced each other's group pride, but not self-pride. The second study followed emotions in 27 task groups (N = 195) across 3 moments in time. Longitudinal social network analyses showed that group members adjusted their group pride, but not their self-pride, to members they perceived to be more influential. Findings from both studies are consistent with a social referencing account of emotion spreading.
Enhanced separation of nitrophenols from wastewater by using ammonium ionic liquid with thiocyanate anion in supported liquid membrane
Creators: name: Kulkarni, Prashant Shripad
name: Shaikh, Vasi Ahmed Ebrahim
name: Sutradhar, Monish
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: The present investigation deals with separation of various types of nitrophenols using SILM technique. Several ionic liquids were developed and the SILM parameters such as role of ILs, feed and strip phase concentration, wastewater pH, salt effect and mixture of pollutants were thoroughly investigated. The percentage extraction and stripping, flux, apparent rate constants and selectivity were evaluated. The selected ammonium IL being more polar than the imidazolium IL showed better separation of 2-nitrophenol. The SILM constituting an ammonium IL with SCN anion exhibited extraction efficiency of >96% and Ka: 0.264 h−1. The change in feed concentration showed maximum transport of nitrophenol at 300 ppm concentration (Ka: 0.673 h−1). The membranes were repeated for 4 cycles which demonstrated good stability for runs of more than 48 hours. The selectivity of 2-nitrophenol, 2,4-dinitrophenol, 2,4,6- trinitrophenol over nitrobenzene was 26, 36 and 58, respectively. The morphology of membranes was studied by using FTIR and FE-SEM and the transport mechanism was elucidated. With the optimized parameters, a concentration factor of 7 can be achieved in the present SILM system. The application of SILM including ammonium IL with SCN anion shows a promising potential for the treatment of various types of nitrophenol bearing wastewater.
Hydrophobic deep eutectic solvent effect on acrylic acid separation from aqueous media by using reactive extraction and modeling with response surface methodology
Creators: name: Lalikoglu, Melisa
name: Aşçı, Yavuz Selim
name: Tarım, Burcu Sırma
name: Yıldız, Mahmut
name: Arat, Refik
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Hydrophobic deep eutectic solvents (HDES) are new-generation green solvents that have emerged in recent years. In this study, the efficiency of using HDES as a solvent in separating acrylic acid from its aqueous solution by reactive extraction method was investigated. As a solvent, HDES prepared with a mixture of TOPO and menthol has been used for the recovery of acrylic acid for the first time. Physical properties of HDES mixtures such as density, viscosity, and refractive index were determined. In reactive extraction experiments, TOPO, one of the two basic components in the solvent, was also employed as an extractant. With the help of response surface methodology based on Box-Behnken design, the effect of the parameters of amount of extractant (0.1–0.9 g), Menthol/TOPO molar ratio (2–4), and initial acid concentration (3–9%) on the distribution coefficient was investigated and the model equation was formed. The highest distribution coefficient (D = 7.8) was achieved with the molar ratio of Menthol/TOPO is 2. Upon examining all the results obtained, it was seen that more than 90% of acrylic acid could be extracted from the aqueous phase to the organic phase.
Heart (Medical illustrations, Drawings)
Creators: name: Francone, Clarice Ashworth
Publisher: name: Oregon Health & Science University
Year: 0
Subjects: Edwards, M. Lowell (Miles Lowell)
Starr, Albert, 1926-
Medical Illustration
Heart Valve Prosthesis
Cardiac Surgical Procedures

description: Mounted drawings depicting the installation and workings of the artificial heart valve invented by Lowell Edwards and Albert Starr at OHSU in 1960.
A Russian adaptation of the tinnitus handicap inventory
Creators: name: Roth, Yehudah
name: Yahav Oron
name: Sergeeva, Nataliya V.
name: Kazlak, Mazen
name: Barbalat, Irina
name: Spevak, Stanislav
name: Lopatin, Andrey S.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Engineering

description: Objective: To establish a Russian version of the English THI. Design: The English THI (THI-E) was translated into Russian by two bilingual investigators, independently. The final Russian THI version (THI-R) was constructed by a third investigator, from the two translations. This version was administered to fifty consecutive patients at a tinnitus clinic. Participants also assessed the loudness of their tinnitus, and completed the Russian versions of the Beck's depression inventory and the state anxiety Inventory. Study sample: The participants were fifty consecutive patients (older than 18 years of age with a tinnitus lasting over three months) who were treated at a tinnitus clinic. Results: A very good internal consistency was found (α = 0.94), with significant correlation between the THI-R score and the Beck depression inventory score. Factor analysis confirmed a uni-dimensional structure of the inventory. Conclusions: A valid and reliable THI-R questionnaire was constructed.
The Common Agricultural Policy of the European Union - the present and the future. Non-EU Member States point of view
Creators: name: Wigier, Marek (Ed.)
name: Kowalski, Andrzej (Ed.)
name: Wigier, Marek (Ed.)
name: Kowalski, Andrzej (Ed.)
Publisher: name: Unknown
Year: 2018
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: Land Economics/Use
subject: agrarian policy
subject: agrarian system
subject: agricultural land sale
subject: agricultural market
subject: agricultural policy
subject: agriculture
subject: Common Agricultural Policy
subject: European Union
subject: financial support
subject: financial system development
subject: land market and
subject: Poland
subject: rural development
subject: rural territories development
subject: Serbia
subject: Ukraine
subject: urban agriculture

description: This monograph was prepared under the Multi-Annual Programme 2015-2019 “The Polish and the EU agricultures 2020+. Challenges, chances, threats, proposals”. The publication is a collection of selected papers delivered at the 22th edition of the International Scientific Conference organized by the Institute of Agricultural and Food Economics - National Research Institute. The theme of the conference was "The Common Agricultural Policy of the European Union – the present and the future. The conference was placed on 5-7 December 2017 in Stary Jab􀃡onki in Poland. Common Agricultural Policy was and still is one of the key pillars of European integration. Published in two volumes materials refer directly to the current and future of the CAP in EU and non EU member states, the strategic objectives and principles of agricultural policy for the agri-food sector and rural areas, address the issues of equilibrium between agriculture, forestry and land use, relate to the dilemmas for the EU budget and the CAP after 2020, CAP instruments and their adjustment, transformations of the rural economy and programming of the rural and agricultural policy, as well as productivity and production efficiency and tensions between sectoral action and between different models of territorial activities. Chapters: Urban agriculture: a framework for agricultural policy – present and future. Land market and a village-keeping model of the agrarian system of Ukraine. Agrarian policy in the European Union and financial support to Serbia. Ukrainian agricultural market regulation tools: their effectiveness and directions of improvement. The Common Agricultural Policy of the European Union and the ways of its implementation in Ukraine. Farm’s financing patterns and financial system development: evidence from Ukraine and Poland. The moratorium on agricultural land sale as a limiting factor for rural development. Solutions to the problems of rural territories development as a sign of their positive brand.
description: DOI:10.30858/pw/9788376587448
Long-term electrode impedance changes and failure prevalence in cochlear implants
Creators: name: Dowell, Richard
name: Newbold, Carrie
name: Risi, Frank
name: Hollow, Rodney
name: Yusmeera Yusof
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Medicine
subject: Engineering

description: Objective: This study assessed the prevalence of electrode failures and electrode impedance measures in Nucleus cochlear implants around initial activation (an average of 16 days after surgery) and after 8 to 12 years of device use. Design: Retrospective data from the Melbourne Cochlear Implant Clinic was collated and analysed. Study sample: Included in this study were 232 adults, all of whom were implanted at the clinic between March 1998 and August 2005. Results: Overall 0.5% of electrodes failed over the entire test period, with 5.6% of devices showing one or more electrode failure. The majority of these failures were recorded by initial activation. The numbers of electrode failures have decreased over time with array type, such that no failures were recorded with the currently available Contour Advance array. Array type was shown to affect electrode impedance at both time points, with the Contour and Contour Advance arrays having significantly higher absolute values than the Banded array. However, the Banded array had significantly higher area-normalized impedances at initial and final measures than the Contour and Contour Advance array. Conclusions: A relatively low incidence of electrode failures were recorded for the Nucleus devices of these recipients. Electrode impedance dropped for all array types after 8 to 12 years of device use.
LNG bunker demand prediction : an instrument for marine fuel strategy in Australia
Creators: name: Merien-Paul, RH
Publisher: name: University of Tasmania
Year: 2024

description: Maritime transportation has been the most favourable and efficient means of carrying goods over vast distances. According to recent figures, more than 90% of goods transported worldwide are made through shipping. With the growth to economies and population the industry is in a continuous growth. The dark side of it is the harmful emissions from ships, mainly due to the innate low grade chemical compositions in conventional marine fuel. Continued growth of ships’ emissions and their accumulative negative effects on the environments are a grave concern for all stakeholders in the maritime industry. As a result, governments and other regulatory authorities are taking stringent measures to reduce emissions from ships. Amongst the various emission reduction approaches taken by the industry to comply these regulations, the use of LNG as a marine fuel is becoming the popular choice.
Whilst countries such as Norway and the key members of the Europa Union are actively promoting the adoption of LNG for fuelling ships in Emission Control Areas, lack of bunkering infrastructure and supporting initiatives are still a hindrance for its global uptake. Australia’s numerous LNG projects, when they reach their intended capacity, are projected to make it the leading natural gas exporter in near future. However, vessels trading in Australian waters continue to consume low quality fuel oils in their entirety, while on the ecological front, sensitive ecosystems in Australia are under siege due to detrimental effects of climate change. Endorsing LNG as a marine fuel in Australia would therefore bring great financial and environmental benefits to the nation. Lack of such initiatives manifests the absence of reliable research and a coherent policy which could motivate the industry towards use of LNG as a marine fuel in Australia.
This study aimed to explore the potential of LNG as a marine fuel in short-sea shipping and international commercial shipping. The preliminary stages of the research comprised of an in-depth literature review with reference to the evolution of LNG as a marine fuel globally, as well as in an Australian perspective. The findings revealed the absence of a robust motivation to formulate a coherent strategy in Australia for adoption of LNG as a marine fuel. It is expected that such an inspiration could be provided by a reliable LNG demand prediction. A methodology has also been constructed in this study for prediction of LNG demand in Australia.
The accuracy of the model heavily depends on the estimation of fuel consumption in ships. The current estimation methods are based on top-to-down and bottom-up approaches. A case study was conducted with in-situ data to assess the accuracy of the two approaches. Results of the case study has shown that current methods estimate more than 57% high fuel consumption compared to actual values and thus, it is important to use in-situ data to improve the accuracy of ship fuel consumption and LNG bunker demand prediction.
title: A novel selection strategy for antibody producing hybridoma cells based on a new transgenic fusion cell line
Creators: name: Listek, Martin
name: Hönow, Anja
name: Gossen, Manfred
name: Hanack, Katja
Publisher: name: Universität Potsdam
Year: 2020

description: The use of monoclonal antibodies is ubiquitous in science and biomedicine but the generation and validation process of antibodies is nevertheless complicated and time-consuming. To address these issues we developed a novel selective technology based on an artificial cell surface construct by which secreted antibodies were connected to the corresponding hybridoma cell when they possess the desired antigen-specificity. Further the system enables the selection of desired isotypes and the screening for potential cross-reactivities in the same context. For the design of the construct we combined the transmembrane domain of the EGF-receptor with a hemagglutinin epitope and a biotin acceptor peptide and performed a transposon-mediated transfection of myeloma cell lines. The stably transfected myeloma cell line was used for the generation of hybridoma cells and an antigen- and isotype-specific screening method was established. The system has been validated for globular protein antigens as well as for haptens and enables a fast and early stage selection and validation of monoclonal antibodies in one step.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 865
Virtual Podium Keynote: Compound Identification and Exposomics: DIY Databases?
Creators: name: Schymanski, Emma
name: Bolton, Evan
name: Helmus, Rick
name: Kondic, Todor
name: Thiessen, Paul
name: Zhang, Jian (Jeff)
Publisher: name: Zenodo
Year: 2020
Subjects: Compound Identification
Exposomics
PubChem
MetFrag
NORMAN Suspect List Exchange

description: In light of recent events, many of us have been impacted by the cancellation of conferences and meetings. We are not only losing the opportunity to present our research, but a chance to connect with our community. Virtual Podium is a platform and opportunity to present and learn about compelling scientific research. Our third session will be focused on Compound Identification. Our keynote speaker this week will be Emma Schymanski who is the PI of Environmental Cheminformatics at the University of Luxembourg. Session 3: Compound Identification
 Friday, April 10, 2020 at 12:00-1:00PM PDT (3:00-4:00PM EDT)
 Session 3 - Compound Identification: https://www.eventbrite.com/e/101426613732
Intestines (Medical illustrations, Drawings)
Creators: name: Francone, Clarice Ashworth
Publisher: name: Oregon Health & Science University
Year: 0
Subjects: Medical Illustration
Digestive System
Intestine, Large
Digestive System Neoplasms

description: Two printed drawings, one of the digestive system and another only of the large intestine. Also contains two mounted drawings, one of a pyloric tumor of the large intestine and another of a portion of the large intestine.
Supplementary Figures 1-6, Supplemental Table and methods from Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation
Creators: name: Kuchler, Oliver
name: Gerlach, Jule
name: Vomhof, Thomas
name: Hettich, Johannes
name: Steinmetz, Julia
name: Gebhardt, J. Christof M.
name: Michaelis, Jens
name: Knöll, Bernd
Publisher: name: The Royal Society
Year: 2022
Subjects: Biophysics
Cell Biology

description: In cells, all proteins encoded by the same gene do not behave uniformly but engage in functional subpopulations induced by spatial or temporal segregation. While conventional microscopy has limitations in revealing such spatial and temporal diversity, single-molecule tracking (SMT) microscopy circumvented this problem and allows for high-resolution imaging and quantification of dynamic single-molecule properties. Particularly in the nucleus, SMT has identified specific DNA residence times of transcription factors (TFs), DNA-bound TF fractions and positions of transcriptional hot-spots upon cell stimulation. By contrast to cell stimulation, SMT has not been employed to follow dynamic TF changes along stages of cell differentiation. Herein, we analysed the serum response factor (SRF), a TF involved in the differentiation of many cell types to study nuclear single-molecule dynamics in neuronal differentiation. Our data in living mouse hippocampal neurons show dynamic changes in SRF DNA residence time and SRF DNA-bound fraction between the stages of adhesion, neurite growth and neurite differentiation in axon and dendrites. Using TALM (tracking and localization microscopy), we identified nuclear positions of SRF clusters and observed changes in their numbers and size during differentiation. Furthermore, we show that the SRF cofactor MRTF-A (myocardin-related TF or MKL1) responds to cell activation by enhancing the long-bound DNA fraction. Finally, a first SMT co-localization study of two proteins was performed in living cells showing enhanced SRF/MRTF-A co-localization upon stimulation. In summary, SMT revealed modulation of dynamic TF properties during cell stimulation and differentiation.