cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles
Creators: name: Erdbrügger, U
name: Blijdorp, CJ
name: Bijnsdorp, IV
name: Borràs, FE
name: Burger, D
name: Bussolati, B
name: Byrd, JB
name: Clayton, A
name: Dear, JW
name: Falcón-Pérez, JM
name: Grange, C
name: Hill, Andrew
name: Holthöfer, H
name: Hoorn, EJ
name: Jenster, G
name: Jimenez, CR
name: Junker, K
name: Klein, J
name: Knepper, MA
name: Koritzinsky, EH
name: Luther, JM
name: Lenassi, M
name: Leivo, J
name: Mertens, I
name: Musante, L
name: Oeyen, E
name: Puhka, M
name: van Royen, ME
name: Sánchez, C
name: Soekmadji, C
name: Thongboonkerd, V
name: van Steijn, V
name: Verhaegh, G
name: Webber, JP
name: Witwer, K
name: Yuen, PST
name: Zheng, L
name: Llorente, A
name: Martens-Uzunova, ES
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field.
Enhanced biological activity of ACPs/cc/cs/PVA composite bone cement: a study on degradation, mineralization, and bone repair properties
Creators: name: Yang, Yanan
name: Zhao, Min
name: Li, Junfeng
name: Hou, Yi
name: Wang, Li
name: Zhou, Haodong
name: Zhang, Peicong
name: He, Jingchuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The application of calcium phosphate cement in bone repair is often limited by its restricted degradation and mineralization capabilities. Here, we developed a novel composite material integrating amorphous calcium phosphates (ACPs) and calcium citrate (CC) to enhance biological activity. The composite was combined with powdered chitosan (CS) and liquid polyvinyl alcohol (PVA) to formulate the ACPs/CC/CS/PVA bone cement. We investigated the influence of varying PVA concentrations (0.3%, 0.6%, 1.0%, and 1.5%) on the cement’s setting time, hydrophilicity, compressive strength, pH, calcium release rate, and degradation rate. We find the ACPs/CC/CS/PVA bone cement demonstrates favorable injectability and anti-washout characteristics within the PVA concentration range of 0.3–1.5%. An elevated PVA concentration is correlated with enhanced anti-washout properties and improved compressive strength, reaching 42.8 MPa, which is essential for maintaining mechanical stability at the defect site. Additionally, the 1.5% PVA cement formulation ensures an adequate calcium ion concentration (6.5–9.5 mg/L) for the beginning of bone repair. Furthermore, in vivo animal studies have confirmed the biocompatibility of the ACPs/CC/CS/PVA bone cement. Controlled release of Ca2+ and PO43− ions from ACPs is suggested to facilitate osteoconduction and osteogenesis, highlighting the material’s prospect in bone repair applications.
title: Will International Law Retain the Upper Hand?: Diplomatic Asylum and Its Legal Frameworks in Europe and Latin America: Lessons from the Cases of Julian Assange and Jorge Glas
Creators: name: Kohte, Anna
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2025
Subjects: subject: 340

description: The case of Jorge Glas has brought the legal status of diplomatic asylum in public international law back into the public spotlight. In this Saar Blueprint, Anna Kohte examines and compares the legal frameworks in Europe and Latin America. She begins with the case of Julian Assange, who was granted asylum in the Ecuadorian embassy in London in 2012. She points out that in Europe, diplomatic asylum is not recognised under either treaty law or customary international law. The situation in Latin America is different. Using the case of former Ecuadorian Vice President Jorge Glas, who sought refuge in the Mexican Embassy in Ecuador, the author analyses the legal implications of diplomatic asylum in Latin America. Following Glas's violent abduction from the embassy by Ecuadorian special forces and his subsequent detention, she examines the extent to which both Ecuador and Mexico violated legal obligations under public international law.
description: Saar Blueprints
Planning a new collection space for the Royal Horticultural Society's specialist herbarium of ornamental plants
Creators: name: Harvey, Yvette
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Planning a new collection space for the Royal Horticultural Society's specialist herbarium of ornamental plants by Yvette Harvey of Keeper Of The Herbarium Royal Horticultural Society (RHS) Woking United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Tailoring surgical sutures with chitosan and non-thermal atmospheric plasma: biofunctionalization for antimicrobial efficacy and enhanced wound healing
Creators: name: Ceylan, Hülya Kuduğ
name: Girgiç, Ezgi
name: Özdemir, Gizem Dilara
name: Ercan, Utku Kürşat
name: Nalbantsoy, Ayşe
name: Elibol, Murat
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Surgical sutures serve as medical devices designed to facilitate the closure of wounds by securing opposing tissues. While sutures are an integral part of the surgical healing process, also present favorable surfaces for microbial attachment, increasing surgical site infections (SSIs). In this study, sutures that have antimicrobial and improved wound healing properties are described as novel approaches for minimizing SSIs. The absorbable multifilament suture, poly (glycolic-co-lactic acid) (PGLA), and non-absorbable multifilament suture (silk) are treated with non-thermal atmospheric plasma (NTAP) and subsequently coated with chitosan/chitosan nanoparticles (Ch/ChNp). Suture samples are analyzed in terms of antibacterial properties, in vitro bioactivity, wound healing efficiency, mechanical strength, chemical characterization, and surface morphologies. Bacterial adherence of Staphylococcus aureus and Escherichia coli on both sutures is inhibited effectively due to the surface modification after plasma treatment. The NTAP treatment results in reduced wound healing for silk sutures without a selective effect on PGLA sutures. However, subsequent coating with Ch/ChNp significantly enhances wound healing for both sutures. Although the maximum tensile strength decreases after NTAP treatment, improves following the Ch/ChNp coating. Our findings indicate that the developed sutures demonstrate notable antimicrobial properties, enhance wound healing, and hold promise as a potential material for suturing applications.
Chromosome-level genome assembly of Japanese anchovy (Engraulis japonicus)
Creators: name: 王瑞祥
Publisher: name: CNGB
Year: 2024
Subjects: Genome sequencing and assembly
Genome sequencing
Assembly
Monoisolate
Agricultural

description: The Japanese anchovy (Engraulis japonicus) holds significant ecological and commercial importance as a Clupeiform marine fish species found in the northwest Pacific marginal seas. The lack of genomic resources hampers our understanding of the genetic diversity and differentiation, as well as the evolutionary dynamics of the species. Here, we assembly a high-quality chromosome-level genome sequence using PacBio HiFi long reads and Hi-C sequencing technology.
Supplemental Material, DS_10.1177_2325967120959284 - Biomechanics of Ankle Ligament Reconstruction: A Cadaveric Study to Compare Stability of Reconstruction Techniques Using 1 or 2 Fibular Tunnels
Creators: name: Gautschi, Martina
name: Bachmann, Elias
name: Shirota, Camila
name: Götschi, Tobias
name: Renner, Niklas
name: Wirth, Stephan H.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental Material, DS_10.1177_2325967120959284 for Biomechanics of Ankle Ligament Reconstruction: A Cadaveric Study to Compare Stability of Reconstruction Techniques Using 1 or 2 Fibular Tunnels by Martina Gautschi, Elias Bachmann, Camila Shirota, Tobias Götschi, Niklas Renner and Stephan H. Wirth in Orthopaedic Journal of Sports Medicine
Νευρωτισμός
Creators: name: Λίτσα, Ιωάννα Νικολάου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Νευρωτισμός
Θεωρία των πέντε παραγόντων της προσωπικότητας
Αιτία νευρωτισμού
Neuroticism
Five factor theory of personality
Causes of neuroticism

description: Ο νευρωτισμός, στην ψυχολογία και την ανάπτυξη, αποτελεί μια ευρεία χαρακτηριστική διάσταση της προσωπικότητας που εκφράζει το βαθμό στον οποίο ένα άτομο βλέπει το περιβάλλον ως αναστατωμένο, επικίνδυνο και ανασφαλές. Κάθε άτομο μπορεί να τοποθετηθεί οπουδήποτε σε αυτή τη διάσταση της προσωπικότητας μεταξύ ακραίων πόλων. Τα έντονα νευρωτικά άτομα τείνουν να είναι ασταθή (δηλαδή, ευαίσθητα σε συχνά μεταβαλλόμενα συναισθήματα), ανήσυχα, τεταμένα και αποτραβηγμένα. Τα άτομα με χαμηλό νευρωτισμό τείνουν να είναι χαρούμενα, με αυτοπεποίθηση και σταθερότητα. Οι τελευταίοι αντιμετωπίζουν λιγότερα σωματικά και ψυχολογικά προβλήματα και λιγότερο άγχος από ό,τι τα έντονα νευρωτικά άτομα. Η αγωνία και η δυσαρέσκεια συμβαδίζουν με τον νευρωτισμό. Όσοι έχουν υψηλή βαθμολογία στην κλίμακα του νευρωτισμού είναι πιο πιθανό να είναι δυσαρεστημένοι τόσο με τον εαυτό τους όσο και με τη ζωή τους. Τείνουν να αισθάνονται άβολα και να παραπονιούνται για δευτερεύοντα προβλήματα υγείας σε διάφορα πλαίσια. Τα αρνητικά συναισθήματα (όπως το άγχος, η απόγνωση, η οργή και η ενοχή) είναι πιο συχνά σε άτομα με νεύρωση. Υψηλοί βαθμοί νευρωτισμού έχουν συνδεθεί σε εμπειρικές έρευνες με ποικίλα αρνητικά αποτελέσματα για το νευρωτικό άτομο και τα αγαπημένα του πρόσωπα
description: Neuroticism, in psychology and development, is a broad characteristic dimension of personality that expresses the degree to which a person views the environment as upsetting, dangerous, and unsafe. Each person can be placed anywhere on this personality dimension between extreme poles. Highly neurotic individuals tend to be unstable (ie, sensitive to frequently changing emotions), anxious, tense, and withdrawn. People with low neuroticism tend to be happy, confident and stable. The latter face fewer physical and psychological problems and less stress than highly neurotic individuals. Anxiety and resentment go hand in hand with neuroticism. Those who score high on the neuroticism scale are more likely to be dissatisfied with both themselves and their lives. They tend to feel uncomfortable and complain of minor health problems in various contexts. Negative emotions (such as anxiety, despair, anger, and guilt) are more common in people with neurosis. High levels of neuroticism have been linked in empirical research to a variety of negative outcomes for the neurotic person and their loved ones
Elidor_et_al._Revue_Decision_Regret_Supplementary_file_1_20200903.rjf_online_supp – Supplemental material for Extent and Predictors of Decision Regret among Informal Caregivers Making Decisions for a Loved One: A Systematic Review
Creators: name: Elidor, Hélène
name: Rhéda Adekpedjou
name: Zomahoun, Hervé Tchala Vignon
name: Charif, Ali Ben
name: Titilayo Tatiana Agbadjé
name: Rheault, Nathalie
name: Légaré, France
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Elidor_et_al._Revue_Decision_Regret_Supplementary_file_1_20200903.rjf_online_supp for Extent and Predictors of Decision Regret among Informal Caregivers Making Decisions for a Loved One: A Systematic Review by Hélène Elidor, Rhéda Adekpedjou, HervéTchala Vignon Zomahoun, Ali Ben Charif, Titilayo Tatiana Agbadjé, Nathalie Rheault and France Légaré in Medical Decision Making
How Not To Share Your Data: Avoiding Data Horror Stories
Creators: name: Higman, Rosie
Publisher: name: Zenodo
Year: 2017
Subjects: Research Data Management
Data Sharing
Excel

description: This presentation is designed to encourage best practice from researchers when sharing their data. It covers basic issues such as repositories, file formats, and cleaning spreadsheets. It was designed for researchers in the sciences who already have some basic awareness that data sharing has many benefits and is expected by many UK research funders. This presentation should take around 20 minutes to give.
Advancement in development of antimicrobial multilayered porous-fibrous biopolymeric scaffold for wound healing application
Creators: name: Shetty, Shreya S.
name: Khurana, Dolphee
name: Suresh, Ankitha
name: Somu, Pratap
name: Singh, Abhishek Kumar
name: Singh, Bhisham Narayan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Skin wound infections involve a significant risk of mortality and morbidity. The natural wound-healing process can be severely hampered by microbial infections, which can be extremely dangerous for human health. Tissue-engineered skin constructs are used for wound healing applications and to overcome the issues or limitations associated with the applications of autografts, allografts, and xenografts. The present review provides an extensive summary of the advancements and potential uses of the antimicrobial multilayered porous scaffold-based method for creating tissue-engineered skin constructs for wound healing. It explores the extracellular matrix of the skin and its diverse components. It delves into the process of wound healing and examines the role of antimicrobials within it. Additionally, it discusses the benefits of multilayered constructs in wound healing and highlights their successful in vivo application. Furthermore, it discusses the use of scaffolds infused with different antimicrobial agents. Finally, it concludes by addressing future prospects and considerations regarding the utilization of antimicrobial scaffolds in wound healing.
Benefits of structured engagement with target audiences of a health website: Study design for a multi-case study
Creators: name: Tieman, J
name: Lewis, Virginia
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Access to evidence and practice knowledge precedes use, but availability does not guaran-tee reach and uptake by intended audiences. The CareSearch project provides online palliative care evidence and information to support health and aged care professionals as well as patients, carers and families to make informed decisions about care at the end of life. Already established in the palliative care sector, CareSearch commenced planning to extend its reach, and ensure website use is maximised for different audiences. This paper reports on the development of the Engagement Framework which will be used to guide and deliver an Engagement Project which will actively seek feedback and insights from intended users in a structured process. The process for developing the Engagement Framework commenced with a literature review of approaches used in knowledge translation, implementation science, and social marketing. The Engagement Framework comprising eight steps was then developed. The Engagement Framework outlines the series of tasks to be undertaken by team members when working with three target groups (Aged Care; Allied Health; and Patients, Carers and Families). A process/formative evaluation collecting data using qualitative methods is also described for use in the subsequent Engagement Project. The evaluation will explore the experiences of project participants as well as staff implementing the engagement activities. The three target groups will enable a cross-case comparison of the strengths and weaknesses of the approach. Planning, implementing and evaluating engagement with intended audiences, offers one mechanism to identify ways to increase interaction and integration with knowledge users.
Organotin(IV) compounds loaded in thermo- and pH-responsive smart polymeric nanocarriers based on poly(DEGMA-co-OEGMA)-b-poly(DEAEM) a drug releasing system and in vitro anticancer activity
Creators: name: López, Ángela M
name: Licea-Claverie, Angel
name: Gómez, Elizabeth
name: Ramírez, Maria Teresa
name: Ramírez-Jiménez, Alejandro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer

description: Nanocarriers in cancer treatment are important for transport and release of insoluble drugs. In this work, block thermo- and pH-responsive copolymers based on poly(di(ethylene glycol) methyl ether methacrylate-co-oligo(ethylene glycol) methyl ether methacrylate) (PDO) and poly(2-(N,N-diethylamino)ethyl methacrylate) (PDEA) were tested. At pH 7.4 and 37 °C, the title polymers formed micelles which were used for the loading and release of diorganotin(IV) complexes (LSnR2), where L is a Schiff base ligand and R = n-butyl (LSnBu2) or cyclohexyl (LSnCy2). Results revealed that the PDO-b-PDE block copolymers could enhance the solubility of LSnR2(IV) compounds in PBS at pH = 7.4, resulting in good loading capacity (%DLC) and loading efficiency (%DLE), and better release performance (pH-dependent and T-dependent) than the free compound. In vitro cytotoxic activity was evaluated by the sulforhodamine B (SRB) assay against a normal cell line, African green monkey kidney fibroblast (COS-7) and seven human cancer cell lines prostate (PC-3), leukemia (K-562), colon (HCT-15), lung (SKLU-1), central nervous system glia (U-251), breast Strogen receptor-positive (MCF-7) and breast hormone-independent (MDA-MB-231). The non-loaded block copolymers were non-cytotoxic, but the loaded ones showed high cell growth inhibition against human cancer cell lines. Results confirmed that these temperature and pH-sensitive polymeric systems are excellent candidates for the loading and release of potential metallodrugs, such as LSnR2, against diverse types of cancers.
Supplementary Material 1 - Supplemental material for Human–Autonomy Teaming: A Review and Analysis of the Empirical Literature
Creators: name: O’Neill, Thomas
name: McNeese, Nathan
name: Barron, Amy
name: Schelble, Beau
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary Material 1, for Human–Autonomy Teaming: A Review and Analysis of the Empirical Literature by Thomas O’Neill, Nathan McNeese, Amy Barron and Beau Schelble in Human Factors: The Journal of Human Factors and Ergonomics Society
Static and dynamic cell culture of small caliber bilayer vascular grafts electrospun from polycaprolactone
Creators: name: Oztemur, Janset
name: Ozdemir, Suzan
name: Tezcan-Unlu, Havva
name: Cecener, Gulsah
name: Dogruok, Yelit Suen
name: Hockenberger, Aslı
name: Yalcin-Enis, Ipek
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Developing a suitable vascular graft to replace damaged small-caliber vessels and promote tissue regeneration is a critical challenge. This study focuses on bilayer polycaprolactone (PCL) grafts, fabricated by electrospinning, with both randomly distributed and radially oriented fibers. The analysis covers surface morphology, fiber diameter, pore size, cellular behavior, and biodegradability. Human umbilical vein endothelial cells (HUVECs) show an impressive viability of 142.2% after 7 days, while umbilical artery smooth muscle cells (UASMCs) exhibit 112.6%. Fluorescent microscopy indicates a higher viability of HUVECs over UASMCs. On the other hand, less than 10% of HUVECs and less than 5% of UASMCs undergo cell death within 7 days. Biodegradation analysis over 12 months shows a significant weight loss of 65–70% for both types of fiber arrangements. A custom-designed bioreactor enables dynamic cell culture, revealing comparable activity to static cultures. In the dynamic cell culture environment, HUVECs maintain high viability and display robust proliferation at both the 4th and 7th days, supporting the results observed in static cell cultures. These findings underscore the significant potential of bilayer PCL grafts in advancing the field of blood vessels, offering promising avenues for the development of functional vascular replacements with enhanced regenerative capabilities.
Genome Enhanced Marker Improvement for Potato Virus Y Disease Resistance in Potato
Creators: name: Caruana, Brittney
name: Rodoni, Brendan
name: Constable, Fiona
name: Slater, Anthony T
name: Cogan, Noel
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Potato is an important food crop worldwide and is grown in a large number of countries. As such, the crop is under disease pressures and the need for selecting disease resistance genes during breeding programs is essential. Of particular importance within Australia and other parts of the world is the potyvirus, Potato virus Y (PVY). In this paper, three commonly used PVY resistance markers, M45, RYSC3 and M6, were evaluated using existing genomic resources and phenotypic data from the Australian potato breeding program to identify a region where the PVY resistance gene, Ryadg may reside. A region of Chromosome XI was investigated, and a cluster of disease resistance genes was identified that the resistance gene Ryadg is suspected to reside within. Protein characterization was also performed on the putative resistant gene. A specific variant that had complete association with the resistance gene was identified and a single nucleotide polymorphism (SNP) assay was designed to avoid dissociation of marker and gene in future breeding programs. This SNP marker (SNP37279) was validated as a Kompetitive Allele-specific PCR (KASP) genotyping assay and was found to perform more accurately than all previously used markers for detecting Ryadg.
Supplementary Material 1 - Supplemental material for Tactile Vigilance Is Stressful and Demanding
Creators: name: DeLucia, Patricia R.
name: Greenlee, Eric T.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary Material 1, for Tactile Vigilance Is Stressful and Demanding by Patricia R. DeLucia and Eric T. Greenlee in Human Factors: The Journal of Human Factors and Ergonomics Society
Supplemental Material, Appendix_B - Mediators and Effect Modifiers of the Causal Pathway Between Child Exposure to Domestic Violence and Internalizing Behaviors Among Children and Adolescents: A Systematic Literature Review
Creators: name: Carter, Bethan
name: Paranjothy, Shantini
name: Davies, Alisha
name: Kemp, Alison
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, Appendix_B for Mediators and Effect Modifiers of the Causal Pathway Between Child Exposure to Domestic Violence and Internalizing Behaviors Among Children and Adolescents: A Systematic Literature Review by Bethan Carter, Shantini Paranjothy, Alisha Davies and Alison Kemp in Trauma, Violence, & Abuse
Appendix_2 – Supplemental material for Fathers’ Experiences of Perinatal Loss: A Sample Meta-Synthesis Study
Creators: name: Ruveyde Aydin
name: Kabukcuoğlu, Kamile
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160301 Family and Household Studies
subject: FOS: Sociology
subject: Sociology

description: Supplemental material, Appendix_2 for Fathers’ Experiences of Perinatal Loss: A Sample Meta-Synthesis Study by Ruveyde Aydin and Kamile Kabukcuoğlu in Journal of Family Issues
Care plus study: a multi-site implementation of early palliative care in routine practice to improve health outcomes and reduce hospital admissions for people with advanced cancer: a study protocol
Creators: name: Philip, J
name: Le Gautier, R
name: Collins, A
name: Nowak, AK
name: Le, B
name: Crawford, GB
name: Rankin, N
name: Krishnasamy, M
name: Mitchell, G
name: McLachlan, SA
name: IJzerman, M
name: Hudson, R
name: Rischin, D
name: Sousa, TV
name: Sundararajan, Vijaya
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Current international consensus is that ‘early’ referral to palliative care services improves cancer patient and family carer outcomes. In practice, however, these referrals are not routine. An approach which directly addresses identified barriers to early integration of palliative care is required. This protocol details a trial of a standardized model of early palliative care (Care Plus) introduced at key defined, disease-specific times or transition points in the illness for people with cancer. Introduced as a ‘whole of system’ practice change for identified advanced cancers, the key outcomes of interest are population health service use change. The aims of the study are to examine the effect of Care Plus implementation on (1) acute hospitalisation days in the last 3 months of life; (2) timeliness of access to palliative care; (3) quality and (4) costs of end of life care; and (5) the acceptability of services for people with advanced cancer. Methods: Multi-site stepped wedge implementation trial testing usual care (control) versus Care Plus (practice change). The design stipulates ‘control’ periods when usual care is observed, and the process of implementing Care Plus which includes phases of planning, engagement, practice change and evaluation. During the practice change phase, all patients with targeted advanced cancers reaching the transition point will, by default, receive Care Plus. Health service utilization and unit costs before and after implementation will be collated from hospital records, and state and national health service administrative datasets. Qualitative data from patients, consumers and clinicians before and after practice change will be gathered through interviews and focus groups. Discussion: The study outcomes will detail the impact and acceptability of the standardized integration of palliative care as a practice change, including recommendations for ongoing sustainability and broader implementation. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN 12619001703190. Registered 04 December 2019.
LOAD-intensity and time-under-tension of exercises for men who have Achilles tendinopathy (the LOADIT trial): a randomised feasibility trial
Creators: name: Hasani, F
name: Haines, T
name: Munteanu, Shannon
name: Schoch, P
name: Vicenzino, B
name: Malliaras, P
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: One potential reason for disparate outcomes of exercise for Achilles tendinopathy is poor knowledge about whether exercise parameters (i.e. different exercise doses) influence outcome. Whether parameters that are important for tendon adaptation influence clinical outcomes in Achilles tendinopathy has not been investigated. Therefore, this research aimed to assess the feasibility of conducting a fully powered randomised trial to investigate the efficacy of different load-intensity and time-under-tension exercise parameters for Achilles tendinopathy. Methods: A factorial four-arm, randomised trial. Forty-eight male participants (18–70 years old) with mid-portion Achilles tendinopathy (≥ 3 months) were recruited. Participants were randomly allocated to high (6 repetition maximum) or low intensity (18 repetition maximum) exercise, performed with either high (6 s per cycle) or low (2 s per cycle) time-under-tension. Participants performed 12-weeks of standing and seated calf raise exercises three times per week in a gym setting using a Smith machine. One session per week was supervised (via videoconference). Primary feasibility outcomes (recruitment and retention rate, exercise adherence and fidelity [i.e. time-under-tension, volume, load intensity], incidence of adverse events, health care use and productivity cost) were collected weekly. Means and standard deviations were determined for parametric data, medians and interquartile range for non-parametric continuous data, and frequency counts for discrete data. Results: Total recruitment (76%) and retention (90%) rates were high. Exercise adherence ranged from 45 to 63% and fidelity ranged from 8 to 83% across the groups. Thirty-one participants reported 64 adverse events over the 3 months. Twenty-one participants (70%) reported mild events. Participants reported reduced presenteeism more than absenteeism. Conclusions: A fully powered trial is feasible. The proposed trial design and interventions demonstrated acceptable recruitment and retention rates and safety profile. However, exercise fidelity and adherence to the gym-based intervention was not acceptable. Strategies to improve intervention adherence and fidelity should be considered in future trials. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12618001315202. Registered retrospectively on August 6th, 2018.
The Role of Trust in the Care of Young Children with Type 1 Diabetes
Creators: name: DeCosta, Patricia
name: Skinner, Timothy
name: Grabowski, Dan
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Using the theoretical framework of Guido Möllering conceptualising trust as a mental process composed of three elements—expectation, interpretation and suspension—we examined the role of trust in relation to young children’s (age ≤ 7 years) psychosocial needs when diagnosed with type 1 diabetes. Based on qualitative interviews with health care professionals (HPCs) from paediatric diabetes clinics in all regions of Denmark, we identified four main themes: trust through meaningful interaction, trust as a key factor at the time of diagnosis, trust in a long-term perspective and caregivers as the bridge to trust. We conclude that trust between young children and HCPs is central to children’s psychosocial experience, as well as a primary need, when children are diagnosed with type 1 diabetes. Trusting relationships counteract children’s experience of fear, anxiety and needle phobia and reinforce HCPs’ experience of providing good psychosocial as well as medical care. The present study offers insights into how trust can positively affect young children’s experience of diagnosis. This study also points out some key barriers to and facilitators of creating trusting relationships. This research is a first step towards a greater understanding that can inform collective future guidelines on the psychosocial care of young children.
Factors Associated With Individual Emergency Preparedness Behaviors: A Cross-Sectional Survey Among the Public in Three Chinese Provinces
Creators: name: Ning, N
name: Hu, M
name: Qiao, J
name: Liu, Chaojie
name: ZHAO, Xiaowen
name: Xu, W
name: Zheng, B
name: Chen, Z
name: Yu, Y
name: Hao, Yanhua
name: Wu, Qunhong
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Introduction: This study aimed to identify factors associated with individual emergency preparedness behaviors which play an important role in effective emergency response. Methods: Data were drawn from a cross-sectional survey conducted in China's Heilongjiang, Guangdong and Sichuan provinces in 2017. Questionnaires were administered through face-to-face interviews, and 2,506 were valid for data analyses. A structural equation model was established to test the direct and indirect effects of the relevant factors on individual emergency preparedness behaviors. Results: Low levels of emergency preparedness were found: 28% of respondents reported being fully/partly prepared. The attitudes of the respondents toward emergency preparedness had the strongest association with emergency preparedness behaviors, with a total effect of 0.483. This was followed by self-efficacy (0.305) and training/exercise (0.295). Risk perception had the weakest effect (0.045) on emergency preparedness behaviors. Discussion: Improving attitudes of the public as well as their ability to prepare for emergency events is important for effective emergency management.
title: „Das ist gespenstisches Verfassungsrecht“
Creators: name: Meinel, Florian
name: Bönnemann, Maxim
name: Bredler, Eva
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2025
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
the gut microbiome sequencing analysis of marine medaka exposed to BPAF
Creators: name: 宦章(Huanzhang)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Multiisolate
Environmental

description: A total of 31 samples, and a total of 31 DNA samples were subjected to high-throughput sequencing, where females were divided into low concentratio BPAF, medium concentration BPAF, high concentration BPAF Four groups, and respectively renamed as CF, LF, MF, HF, group, each group of four parallel, a total of 16 Samples; males were divided into three groups: revived Named CM, LM, MM group, each group of five parallel, a total of 15 samples.
Setting Natural Science Data Free: Scoping UK Collections
Creators: name: Wainwright, Tara
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Setting Natural Science Data Free: Scoping UK Collections by Tara Wainwright of Natural History Museum Bishops Stortford United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Association between short inter-pregnancy interval and placenta previa and placenta accreta spectrum with respect to maternal age at first cesarean delivery
Creators: name: Liang, Yingyu
name: Zhang, Lizi
name: Huang, Lijun
name: Li, Yulian
name: Chen, Jingsi
name: Bi, Shilei
name: Huang, Minshan
name: Tan, Hu
name: Lai, Siying
name: Liang, Jingying
name: Gu, Shifeng
name: Jia, Jinping
name: Wen, Suiwen
name: Wang, Zhijian
name: Cao, Yinli
name: Wang, Shaoshuai
name: Xu, Xiaoyan
name: Feng, Ling
name: Zhao, Xianlan
name: Zhao, Yangyu
name: Zhu, Qiying
name: Qi, Hongbo
name: Zhang, Lanzhen
name: Li, Hongtian
name: Du, Lili
name: Chen, Dunjin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: To explore the association between inter-pregnancy intervals and placenta previa and placenta accreta spectrum among women who had prior cesarean deliveries with respect to maternal age at first cesarean delivery. This retrospective study included clinical data from 9981 singleton pregnant women with a history of cesarean delivery at 11 public tertiary hospitals in seven provinces of China between January 2017 and December 2017. The study population was divided into four groups (<2, 2–5, 5–10, ≥10 years of the interval) according to the inter-pregnancy interval. The rate of placenta previa and placenta accreta spectrum among the four groups was compared, and multivariate logistic regression was used to analyze the relationship between inter-pregnancy interval and placenta previa and placenta accreta spectrum with respect to maternal age at first cesarean delivery. Compared to women aged 30–34 years old at first cesarean delivery, the risk of placenta previa (aRR, 1.48; 95% CI, 1.16–1.88) and placenta accreta spectrum (aRR, 1.74; 95% CI, 1.28–2.35) were higher among women aged 18–24. Multivariate regression results showed that women at 18–24 with <2 years intervals exhibited a 5.05-fold increased risk for placenta previa compared with those with 2–5-year intervals (aRR, 5.05; 95% CI, 1.13–22.51). In addition, women aged 18–24 with less than 2 years intervals had an 8.44 times greater risk of developing PAS than women aged 30-34 with 2 to 5 years intervals (aRR, 8.44; 95% CI, 1.82–39.26). The findings of this study suggested that short inter-pregnancy intervals were associated with increased risks for placenta previa, and placenta accreta spectrum for women under 25 years at first cesarean delivery, which may be partly attributed to obstetrical outcomes.
Effectiveness of clinical criteria in directing patient flow from the emergency department to a medical assessment unit in Queensland, Australia: a retrospective chart review of hospital administrative data
Creators: name: Osborne, S
name: Cleak, Helen
name: White, N
name: Lee, X
name: Deacon, A
name: de Looze, JWM
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Medical Assessment Units (MAUs) have become a popular model of acute medical care to improve patient flow through timely clinical assessment and patient management. The purpose of this study was to determine the effectiveness of a consensus-derived set of clinical criteria for patient streaming from the Emergency Department (ED) to a 15-bed MAU within the highly capacity-constrained environment of a large quaternary hospital in Queensland, Australia. Methods: Clinically coded data routinely submitted for inter-hospital benchmarking purposes was used to identify the cohort of medical admission patients presenting to the ED in February 2016 (summer) and June 2016 (winter). A retrospective review of patient medical records for this cohort was then conducted to extract MAU admission data, de-identified patient demographic data, and clinical criteria. The primary outcome was the proportion of admissions that adhered to the MAU admission criteria. Results: Of the total of 540 included patients, 386 (71 %) patients were deemed to meet the MAU eligibility admission criteria. Among patients with MAU indications, 66 % were correctly transferred (95 % CI: 61 to 71) to the MAU; this estimated sensitivity was statistically significant when compared with random allocation (p-value < 0.001). Transfer outcomes for patients with contraindications were subject to higher uncertainty, with a high proportion of these patients incorrectly transferred to the MAU (73 % transferred; 95 % CI: 50 to 89 %; p-value = 0.052). Conclusions: Based on clinical criteria, approximately two-thirds of patients were appropriately transferred to the MAU; however, a larger proportion of patients were inappropriately transferred to the MAU. While clinical criteria and judgement are generally established as the process in making decisions to transfer patients to a limited-capacity MAU, our findings suggest that other contextual factors such as bed availability, time of day, and staffing mix, including discipline profile of decision-making staff during ordinary hours and after hours, may influence decisions in directing patient flow. Further research is needed to better understand the interplay of other determinants of clinician decision making behaviour to inform strategies for improving more efficient use of MAUs, and the impact this has on clinical outcomes, length of stay, and patient flow measures in MAUs.
SYNTHESIS OF ACETYLENE ALCOHOLS BASED ON THE ETHINYLATION OF SOME HETEROATOMIC ALDEHYDES WITH THE PARTICIPATION OF VARIOUS CATALYSTS
Creators: name: Ziyadullaev, Odiljon
name: Salieva, Muyassar
name: Ablakulov, Lochin
Publisher: name: Zenodo
Year: 2024

description: In this research work, the catalytic systems InBr3/Et3N/Et2O and ProPhenol/Me2Zn/TGF were used for the first time, based on the reactions of enantioselective ethinylation of acetylene, phenylacetylene with some aldehydes - thiophene-2-carbaldehyde, 3-methylthiophene-2-carbaldehyde, furan-2- carbaldehyde, pyridine-3-carbaldehyde, quinoline-2-carbaldehyde and 3-bromo-4-pyridinecarbaldehyde, the synthesis reactions of the corresponding acetylene alcohols were studied. The influence of the used complex systems on the efficiency of the formation of acetylene alcohols is proposed. and reaction mechanisms are presented. A number of factors influencing the yield of the product were studied - temperature, reaction duration, influence of the amount of catalyst and solvents, substrate and reagents. Based on the results obtained, the most alternative conditions for the processes were found. The composition, purity, structure and quantum chemical properties of the synthesized acetylene alcohols were confirmed by modern physicochemical methods - IR, 1H-NMR, 13C-NMR spectroscopy, mass spectrometry, chromatography. A number of production efficiencies of synthesized acetylene alcohols have been determined. In the process, a number of propensities for the nucleophilic addition reaction were determined in accordance with the nature of the substituents retained by the heteroatomic element in the aldehyde molecule, their spatial arrangement and nature of action.
Relationship Between Social Motivation in Children With Autism Spectrum Disorder and Their Parents
Creators: name: Uljarevic, Mirko
name: Frazier, TW
name: Jo, B
name: Phillips, JM
name: Billingham, W
name: Cooper, MN
name: Hardan, AY
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Impairment in social motivation (SM) has been suggested as a key mechanism underlying social communication deficits observed in autism spectrum disorder (ASD). However, the factors accounting for variability in SM remain poorly described and understood. The current study aimed to characterize the relationship between parental and proband SM. Data from 2,759 children with ASD (Mage = 9.03 years, SDage = 3.57, 375 females) and their parents from the Simons Simplex Collection (SSC) project was included in this study. Parental and proband SM was assessed using previously identified item sets from the Social Responsiveness Scale (SRS). Children who had parents with low SM scores (less impairments) showed significantly lower impairments in SM compared to children who had either one or both parents with elevated SM scores. No parent-of-origin effect was identified. No significant interactions were found involving proband sex or intellectual disability (ID) status (presence/absence of ID) with paternal or maternal SM. This study establishes that low SM in children with ASD may be driven, in part, by lower SM in one or both parents. Future investigations should utilize larger family pedigrees, including simplex and multiplex families, evaluate other measures of SM, and include other related, yet distinct constructs, such as social inhibition and anhedonia. This will help to gain finer-grained insights into the factors and mechanisms accounting for individual differences in sociability among typically developing children as well as those with, or at risk, for developing ASD.
Biochemical and Functional Characterization of GALT8, an Arabidopsis GT31 β-(1,3)-Galactosyltransferase That Influences Seedling Development
Creators: name: Narciso, JO
name: Zeng, W
name: Ford, K
name: Lampugnani, ER
name: Humphries, John
name: Austarheim, I
name: van de Meene, A
name: Bacic, Tony
name: Doblin, Monika
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Arabinogalactan-proteins (AGPs) are members of the hydroxyproline-rich glycoprotein (HRGP) superfamily, a group of highly diverse proteoglycans that are present in the cell wall, plasma membrane as well as secretions of almost all plants, with important roles in many developmental processes. The role of GALT8 (At1g22015), a Glycosyltransferase-31 (GT31) family member of the Carbohydrate-Active Enzyme database (CAZy), was examined by biochemical characterization and phenotypic analysis of a galt8 mutant line. To characterize its catalytic function, GALT8 was heterologously expressed in tobacco leaves and its enzymatic activity tested. GALT8 was shown to be a β-(1,3)-galactosyltransferase (GalT) that catalyzes the synthesis of a β-(1,3)-galactan, similar to the in vitro activity of KNS4/UPEX1 (At1g33430), a homologous GT31 member previously shown to have this activity. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) confirmed the products were of 2-6 degree of polymerisation (DP). Previous reporter studies showed that GALT8 is expressed in the central and synergid cells, from whence the micropylar endosperm originates after the fertilization of the central cell of the ovule. Homozygous mutants have multiple seedling phenotypes including significantly shorter hypocotyls and smaller leaf area compared to wild type (WT) that are attributable to defects in female gametophyte and/or endosperm development. KNS4/UPEX1 was shown to partially complement the galt8 mutant phenotypes in genetic complementation assays suggesting a similar but not identical role compared to GALT8 in β-(1,3)-galactan biosynthesis. Taken together, these data add further evidence of the important roles GT31 β-(1,3)-GalTs play in elaborating type II AGs that decorate AGPs and pectins, thereby imparting functional consequences on plant growth and development.