cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
377. P.Z. Uriage-les-Bains
Creators: name: [s.n.]
Publisher: name: [Photochrom Zürich]
Year: 1890

description: "377. P.Z." -- unten links
description: Unbekannte/r Künstler/in
description: Abzugauf Unterlage montiert
description: Abzug mit handschriftlicher Notiz auf der Rückseite der Unterlage; die Jahreszahl wurde zu einem späteren Zeitpunkt notiert, der betroffene Abzug wurde wahrscheinlich erst später in die Ansichtensammlung La Roche einsigniert
description: Digitalisierung=Digitization=Numérisation 2024 TIFF
Pheidole longicornis Emery, 1887, n. sp.
Creators: name: Emery, Carlo
Publisher: name: Zenodo
Year: 1887
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Pheidole
Pheidole longicornis

description: 23. Pheidole longicornis n. sp. Miles. Ph. javanae proxime affinis; differt capite longiore, latitudine maxima haud breviore, sculptura postico latius reticu-lata, frontis et verticis sulco magis impresso, clypeo carinato, antennis longioribus, scapo fere 3/4 spatii quod est inter oculum et apicem lobi occipitalis attingente (in Ph. javana, paulo ultra medium ejus spatii protenso); thorace magis elongato, spinis longioribus, segmento pedunculi 2° angulis magis distinctis. L. 4 1/ 2 mm. Ph. javanae similiima, capite paulo magis elongato, margine occipitali elevato magis distincto, thorace multo magis elongato, mesonoto vix breviore quam metanotum, hoc spinulis majoribus, erectis, petioli segmento 2° magis dilatato; pedes et antennae longiores; sculptura et pilositas ut in Ph. javana. L. 2 3/4- 3 mm. Nias, Gunung Sitoli; parecchie ☿ e un soldato. La ☿ rappresenta una forma intermedia fra la Ph. javana Mayr e velox Em. In quest’ ultima il margine occipitale, già rilevato a forma di collare nella Ph. longicornis si stacca sopra una specie di breve colletto che ricorda quello degli Ischnomyrmex. B. Articoli 8 e 9, del flagello quasi eguali; clava delle antenne di 4 articoli a. Capo senza collo distinto, ma munito soltanto di un collare elevato e tagliente intorno al margine occipitale........... longiceps Sm. b. Capo prolungato indietro in un collo sottile. a. il collo del capo non è dilatato al suo estremo posteriore..... rhaphidiiceps, Mayr. b. collo del capo dilatato ad imbuto indietro. a. fossa antennale senza carena laterale distinta, longipes Sm. p. fossa antennale limitata lateralmente da una carena tagliente più o meno prolungata indietro. 1. torace mediocremente allungato; fossa antennale levigata e interamente circondata da una carena elevata........ laevior Em. 2. torace mediocremente allungato; fossa antennale scolpita di rughe semicircolari nella sua parte posteriore....... Beccarii Em. 3. torace molto allungato, fossa antennale liscia, circondata da una carena elevata incompleta posteriormente....... Swammerdami For.
description: Published as part of Emery, Carlo, 1887, Catalogo delle formiche esistenti nelle collezioni del Museo Civico di Genova. Parte terza (supplemento). Formiche raccolte dal sig. Elio Modigliani in Sumatra e nell'isola Nias., pp. 528-534 in Annali del Museo Civico di Storia Naturale Giacomo Doria (Genova) (2) 5 (25) on page 532, DOI: 10.5281/zenodo.11534
PXR antagonists and implication in drug metabolism
Creators: name: Redinbo, Matthew R.
name: Mani, Sridhar
name: Dou, Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Adopted orphan nuclear receptor (NR), pregnane X receptor (PXR), plays a central role in the regulation of xeno- and endobiotic metabolism. Since the discovery of the functional role of PXR in 1998, there is evolving evidence for the role of PXR agonists in abrogating metabolic pathophysiology (e.g., cholestasis, hypercholesterolemia, and inflammation). However, more recently, it is clear that PXR is also an important mediator of adverse xeno- (e.g., enhances acetaminophen toxicity) and endobiotic (e.g., hepatic steatosis) metabolic phenotypes. Moreover, in cancer therapeutics, PXR activation can induce drug resistance, and there is growing evidence for tissue-specific enhancement of the malignant phenotype. Thus, in these instances, there may be a role for PXR antagonists. However, as opposed to the discovery efforts for PXR agonists, there are only a few antagonists described. The mode of action of these antagonists (e.g., sulforaphane) remains less clear. Our laboratory efforts have focused on this question. Since the original discovery of azoles analogs as PXR antagonists, we have preliminarily defined an important PXR antagonist pharmacophore and developed less-toxic PXR antagonists. In this review, we describe our published and unpublished findings on recent structure-function studies involving the azole chemical scaffold. Further work in the future is needed to fully define potent, more-selective PXR antagonists that may be useful in clinical application.
Accurate approximations for the complex error function with small imaginary argument
Creators: name: Abrarov, S. M.
name: Quine, B. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper we present two efficient approximations for the complex error function $w \left( {z} \right)$ with small imaginary argument $\operatorname{Im}{\left[ { z } \right]} < < 1$ over the range $0 \le \operatorname{Re}{\left[ { z } \right]} \le 15$ that is commonly considered difficult for highly accurate and rapid computation. These approximations are expressed in terms of the Dawson's integral $F\left( x \right)$ of real argument $x$ that enables their efficient implementation in a rapid algorithm. The error analysis we performed using the random input numbers $x$ and $y$ reveals that in the real and imaginary parts the average accuracy of the first approximation exceeds ${10^{ - 9}}$ and ${10^{ - 14}}$, while the average accuracy of the second approximation exceeds ${10^{ - 13}}$ and ${10^{ - 14}}$, respectively. The first approximation is slightly faster in computation. However, the second approximation provides excellent high-accuracy coverage over the required domain.
description: 15 pages, 3 figures
Brief an Johann Jakob Grynaeus
Creators: name: Polanus von Polansdorf, Amandus
Publisher: name: [s.n.]
Year: 1592

description: von A[mandus] Polanus [von Polansdorf]
description: Mit Spuren von einer roten Oblate
description: Abschrift: UB Basel, G2 II 23:Bl.26
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2018 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis, Briefkatalog und Original
description: Verzeichnung=Description=Inventaire Januar 2024 HAN-Katalogisierungsregeln Revision nach Vorlage nni
Brief an Johann Jakob Grynaeus
Creators: name: Polanus von Polansdorf, Amandus
Publisher: name: [s.n.]
Year: 1589

description: von A[mandus] Polanus [von Polansdorf]
description: Mit Spuren von einer roten Oblate
description: Abschrift: G2 II 23:Bl.11
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2018 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis, Briefkatalog und Original
description: Verzeichnung=Description=Inventaire Januar 2024 HAN-Katalogisierungsregeln Revision nach Vorlage nni
Brief an Johann Jakob Grynaeus
Creators: name: Polanus von Polansdorf, Amandus
Publisher: name: [s.n.]
Year: 1592

description: von A[mandus] Polanus [von Polansdorf]
description: Mit roter Oblate
description: Abschrift: UB Basel, G2 II 23:Bl.27
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2018 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis, Briefkatalog und Original
description: Verzeichnung=Description=Inventaire Januar 2024 HAN-Katalogisierungsregeln Revision nach Vorlage nni
Fundamental Limits of Blind Deconvolution Part I: Ambiguity Kernel
Creators: name: Choudhary, Sunav
name: Mitra, Urbashi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Blind deconvolution is an ubiquitous non-linear inverse problem in applications like wireless communications and image processing. This problem is generally ill-posed, and there have been efforts to use sparse models for regularizing blind deconvolution to promote signal identifiability. Part I of this two-part paper characterizes the ambiguity space of blind deconvolution and shows unidentifiability of this inverse problem for almost every pair of unconstrained input signals. The approach involves lifting the deconvolution problem to a rank one matrix recovery problem and analyzing the rank two null space of the resultant linear operator. A measure theoretically tight (parametric and recursive) representation of the key rank two null space is stated and proved. This representation is a novel foundational result for signal and code design strategies promoting identifiability under convolutive observation models. Part II of this paper analyzes the identifiability of sparsity constrained blind deconvolution and establishes surprisingly strong negative results on scaling laws for the sparsity-ambiguity trade-off.
description: 20 pages, 4 figures
Brief an Johann Jakob Grynaeus
Creators: name: Polanus von Polansdorf, Amandus
Publisher: name: [s.n.]
Year: 1588

description: von Amandus Polanus a Polansdorf
description: Abschrift: UB Basel, G2 II 23:Bl.6
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2018 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis, Briefkatalog und Original
description: Verzeichnung=Description=Inventaire Januar 2024 HAN-Katalogisierungsregeln Revision nach Vorlage nni
title: The development of novel heat sinks using selective laser melting
Creators: name: Wong, Matthew
Publisher: name: University of Liverpool Repository
Year: 2023

description: Heat removal from electronic systems relies on forced convection heat transfer from extended surfaces. The favoured extended surface for avionics enclosures is the cast pin fm array. However, due to the increasing heat dissipation of electronic components, the cooling offered by cylindrical arrays will be insufficient in the near future and higher performance extended surfaces are required. The current study introduces a novel manufacturing technique, Selective Laser Melting (SLM), and' demonstrates its ability to fabricate new designs of extended surface that have not previously been considered, primarily due to their geometric complexity. The SLM processing parameters for aluminium 6061, a new material to the technique, were developed to allow the fabrication ofparts that achieved a density of 90% of the parent metal. Investigations on the SLM-fabricated aluminium 6061 revealed that its thermal conductivity was 75 W/mK, 48% less than the thermal conductivity predicted by standard correlations. 65% of the reduction in thermal conductivity was found to be caused by interparticle thermal resistances, the remainder a result ofporosities. The heat transfer and pressure loss performance of several types of heat sink were characterised by experimental investigations. The extended surfaces manufactured and tested included cylindrical arrays, for validation purposes, elliptical, offset strip and diamond arrays, and various types of lattice. In the acceptable flow rate and pressure drop range, a tightly packed diamond array was found to offer the best performance with a 62% improvement in heat transfer over a typical cylindrical pin arrangement and only 60% ofthe pressure loss. Computational Fluids Dynamic (CFD) studies of the flow in three pin arrangements were conducted to aid visualisation of the fluid flow and to assess the predictive capabilities of Fluent, a commercial CFD code. The CFD pressure loss predictions were within 8 % ofthe experimental results and the heat transfer results were found to be qualitatively meaningful. Results from the experimental and CFD studies indicate that laminar flow in streamlined fm arrays with tight pin spacings offers improved heat transfer performance benefits over turbulent flow in cylindrical arrays at a similar flow rate and pressure drop thereby offering the required improvement in performance for high-power electronic components.
Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective
Creators: name: Redinbo, Matthew R.
name: Wallace, Bret D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Xenobiotic compounds undergo a critical range of biotransformations performed by the phase I, II, and III drug-metabolizing enzymes. The oxidation, conjugation, and transportation of potentially harmful xenobiotic and endobiotic compounds achieved by these catalytic systems are significantly regulated, at the gene expression level, by members of the nuclear receptor (NR) family of ligand-modulated transcription factors. Activation of NRs by a variety of endo- and exogenous chemicals are elemental to induction and repression of drug-metabolism pathways. The master xenobiotic sensing NRs, the promiscuous pregnane X receptor and less-promiscuous constitutive androstane receptor are crucial to initial ligand recognition, jump-starting the metabolic process. Other receptors, including farnesoid X receptor, vitamin D receptor, hepatocyte nuclear factor 4 alpha, peroxisome proliferator activated receptor, glucocorticoid receptor, liver X receptor, and RAR-related orphan receptor, are not directly linked to promiscuous xenobiotic binding, but clearly play important roles in the modulation of metabolic gene expression. Crystallographic studies of the ligand-binding domains of nine NRs involved in drug metabolism provide key insights into ligand-based and constitutive activity, coregulator recruitment, and gene regulation. Structures of other, noncanonical transcription factors also shed light on secondary, but important, pathways of control. Pharmacological targeting of some of these nuclear and atypical receptors has been instituted as a means to treat metabolic and developmental disorders and provides a future avenue to be explored for other members of the xenobiotic-sensing NRs.
The Single-Uniprior Index-Coding Problem: The Single-Sender Case and The Multi-Sender Extension
Creators: name: Ong, Lawrence
name: Ho, Chin Keong
name: Lim, Fabian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Index coding studies multiterminal source-coding problems where a set of receivers are required to decode multiple (possibly different) messages from a common broadcast, and they each know some messages a priori. In this paper, at the receiver end, we consider a special setting where each receiver knows only one message a priori, and each message is known to only one receiver. At the broadcasting end, we consider a generalized setting where there could be multiple senders, and each sender knows a subset of the messages. The senders collaborate to transmit an index code. This work looks at minimizing the number of total coded bits the senders are required to transmit. When there is only one sender, we propose a pruning algorithm to find a lower bound on the optimal (i.e., the shortest) index codelength, and show that it is achievable by linear index codes. When there are two or more senders, we propose an appending technique to be used in conjunction with the pruning technique to give a lower bound on the optimal index codelength; we also derive an upper bound based on cyclic codes. While the two bounds do not match in general, for the special case where no two distinct senders know any message in common, the bounds match, giving the optimal index codelength. The results are expressed in terms of strongly connected components in directed graphs that represent the index-coding problems.
description: Author final manuscript
title: Participation in theory and practice in the production of a poverty reduction strategy paper (PRSP) : the case of Bangladesh
Creators: name: Kamruzzaman, Palash
Publisher: name: University of Liverpool Repository
Year: 2023

description: This research interrogates the idea of participation in theory and practice in recent development thought, taking Bangladesh's Poverty Reduction Strategy Paper (PRSP) as a case study. The PRSP framework, the latest in the 'prescription series' from two globally influential trans-national monetary organisations, has been operationalised as a condition for their various aid and debt relationships with poor countries. However, at the same time, the PRSP approach purports to be 'country-owned', tailored in each country through a participatory process. Possible contradictions between genuine participation and its imposition as a condition for obtaining debt and aid led this study to investigate whether participation actually enhanced Bangladesh's PRSP process.
Tiphys (Tiphys) ornatus Koch
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Pionidae
Tiphys
Tiphys ornatus

description: Tiphys (Tiphys) ornatus Koch
Records from the study area: Kashmir—“ Acercus ornatus “ Lundblad (1934); Prasad (1974).
Habitat: Ponds.
Distribution: Holarctic.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 32, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
title: A study of Tawfiq al-Hakim’s Equilibrium doctrine and philosophical narratives
Creators: name: Shaw, Shereen
Publisher: name: University of Liverpool Repository
Year: 2016

description: Tawfiq al-Hakim is known across the Arab world as a pioneer dramatist. He is one of many misunderstood writers and philosophers. My aim is to introduce him to the English-speaking public in order to shed some light on a specific period known to be one of the best in Egypt intellectually and culturally. Former President Nasser’s ideologies, and those of former President Sadat such as his “open-door” policy to the West, have contributed positively to the forming of an intellectual renaissance in Egypt. This rich period in Egyptian history is one that can directly shed light on the literary and philosophical contributions of al-Hakim, and on the social and cultural issues that should be revisited in order to gain an understanding of the problems that face Egyptians today. With this said, it is my hope that by reviving al-Hakim’s philosophical doctrines and by examining the major issues he addresses in his texts, I will be able to explain and clarify some misconceptions about this author, his philosophy and his work. I would also like to show ways in which his distinctive doctrine of equilibrium can be of use to us both in the East and the West. The objectives, accordingly, are twofold: (1) To introduce and critically examine al-Hakim’s equilibrium doctrine; and, (2) To identify the philosophical traits and Western influences that had an impact on his character and philosophy. The core problem that this work will indirectly address is the problem of how philosophy in the Arab world, according to Sari Nusseibeh’s article “The Arab World: What role for philosophy?” has been blatantly used as a tool in order to defend one version or another of the religious beliefs of those who pursued it. I ask what specific role a philosopher or intellectual can play in his or her society and how his philosophy can be put to use. This question is one that has been long forgotten in the Arab world. Freeing the Arab world from the colonizer, back in the 1930s, was clearly a goal for many intellectuals. Today, freeing the Arab mind by introducing a philosophy or an ideology that can be of use to the Muslim world as well as to the West would be a great task to accomplish.
Brief an Johan[n] Jakob Grynaeus
Creators: name: Polanus von Polansdorf, Amandus
Publisher: name: [s.n.]
Year: 1584

description: von Amos Amandus Polanus von Polansdorf
description: Mit rotem Siegel
description: Abschrift: UB Basel, G2 II 23:Bl.1
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2018 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis, Briefkatalog und Original
description: Verzeichnung=Description=Inventaire Januar 2024 HAN-Katalogisierungsregeln Revision nach Vorlage nni
Relative Brauer groups of torsors of period two
Creators: name: Creutz, Brendan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We consider the problem of computing the relative Brauer group of a torsor of period 2 under an elliptic curve E. We show how this problem can be reduced to finding a set of generators for the group of rational points on E. This extends work of Haile and Han to the case of torsors with unequal period and index. Several numerical examples are given.
description: V2: minor errors corrected; appendix added
Nickerson et al. - Supplemental Tables
Creators: name: U'Ren, Jana
name: Nickerson, Megan N.
name: Moore, Lillian
Publisher: name: figshare
Year: 2023
Subjects: Ecology not elsewhere classified
Mycology

description: Excel file containing the Supplemental Tables for Nickerson et al.  Supplemental Table 1. Fungal species, isolation information, OTU designation, host information, and estimates of fungal taxonomy based on BLASTn queries of NCBI nr (excluding environmental sequences) for six oak-associated fungal species that failed to grow in 96-well assay. Supplemental Table 2. Host, geographic, and substrate information for representative isolates of 15 oak-associated fungal species. Supplemental Table 3. Mean and standard deviation of fungal growth (i.e., normalized optical density) with and without glucose. A value of 0.025 was considered the threshold for growth. Supplemental Table 4. Means and standard deviation of normalized fungal growth for each isolate. Letters indicate significant differences in means as a function of concentration after ANOVA (P<0.05) and post-hoc Tukey's HSD. Supplemental Table 5. Means and standard deviation of normalized fungal growth for each isolate. Letters indicate significant differences in means as a function of isolate after ANOVA (P<0.05) and post-hoc Tukey's HSD.
title: Assessments of harms in clinical trials
Creators: name: Hodkinson, Alexander
Publisher: name: University of Liverpool Repository
Year: 2015

description: Introduction and Aims Healthcare interventions are usually associated with a risk of harmful events that must be balanced against the potential favorable outcomes. However reliable evidence on harms for interventions is often inadequate, and hampered by the many challenges that stem from the reporting, analysis and interpretation of harms data in clinical trials. This thesis addresses some of these issues. Methods Reporting of harms data is assessed in a systematic review of reviews and a case study investigating the additional value of harms data reported in clinical study reports (CSRs). A framework for searching and identifying relevant sources of harms data is outlined, and then explored further in a survey assessing current practices in clinical trial units (CTUs). Signal detection methods are introduced, and evaluated using simulated data to assess their performance when detecting safety signals in CTU databases. Results The systematic review highlights that the reporting of harms in RCTs is inconsistent, and often inadequate. In the case study, CSRs presented data on harms, including SAEs which are not reported or mentioned in publications, they also provide more detail about the design, conduct and analysis of the trial which facilitate the assessment of risk of bias in evidence synthesis. A wide range of sources for harms data have been identified, each with distinct strengths and limitations discussed. Selection of appropriate sources depends on the research question, and whether a hypothesis generating or hypothesis testing approach should be taken. Relevant sources have been identified for each approach, with examples of their exploitation in CTUs evaluated in the survey. The simulation study has shown that some of the current available signal detection methods are not able to control the false discovery rate well, and are only able to detect few safety signals for small or sparse data. Conclusions The work carried out within this thesis provides some recommendations to address the reporting, conduct, and analysis of harms in clinical trials. Wider adoption of recommendations made by the CONSORT-harms guideline will enhance the quality of reporting and improve subsequent evidence synthesis. Recent initiatives to promote open access to clinical trials data including CSRs is a major step towards supporting better data transparency. It is important to identify and consider different sources that are most likely to yield robust data on harms of interest, rather than relying on studies that cannot reliably detect harm. The survey identified published literature and systematic reviews as the most common source being used in the trial safety monitoring within CTUs. Signal detection methods are potentially unsuitable for use in CTUs. Further tools and guidelines for enhanced signal detection are needed in clinical trials.
Deutsches Copier Buch
Creators: name: Forcart-Weiss & Söhne
Publisher: name: [s.n.]
Year: 1840

description: Darin: Register
description: Deutsch
description: Verzeichnung=Description=Inventaire 12.04.2023 Automatisierter Import Archivbestand
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
title: Gelingensbedingungen von Schulreform
title: Bildungshistorische Befunde als Schlüssel zum pädagogischen Verständnis von Schulentwicklungsprozessen und als Erweiterung des Theorienverbundes zur Schulreform
titleType: Subtitle
Creators: name: Link, Jörg-Werner
Publisher: name: Universität Potsdam
Year: 2023
Subjects: subject: 370 Bildung und Erziehung

description: Historische Schulforschung und Schulentwicklungsforschung haben an schulischen Reformprozessen zwar ein vergleichbares Forschungsinteresse, stehen aber bislang nicht im wissenschaftlichen Dialog. Gleichwohl existierten nahezu sämtliche Praxen der gegenwärtigen Schul- und Unterrichtsentwicklung bereits in den Schulreformprozessen der historischen Reformpädagogik. Auf der Grundlage von elf bildungshistorischen und schulpädagogischen Quellenstudien wird ein Struktur- und Handlungsmodell gelingender Schulreformprozesse entwickelt, das sich aus der akteursnahen Eigenlogik pädagogisch-praktischer Reformprozesse ableitet. Die Studien analysieren fallorientiert und quellengestützt die Reformpraxen an historischen Reformschulen des 20. Jahrhunderts und geben vertiefte Einblicke in historische Schul(reform)praxis. Bezugspunkt ist dabei jeweils die Einzelschule als pädagogische Handlungseinheit. Die historisch-empirisch entwickelte „Fünf-plus-zwei-K-Struktur gelingender Schulreformprozesse“ wurde an 100 gegenwärtigen Reformschulen überprüft und konnte im Ergebnis in einem Zeitraum von rund einhundert Jahren als wiederkehrend validiert werden. Die Befunde tragen insgesamt zum pädagogischen Verständnis von Schulreformprozessen bei und bilden eine professionsnahe Referenz für die Theoriebildung innerhalb der Schulentwicklungsforschung.
description: Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe; 825
title: Studies on Salmonid Fishes in Llyd Tegid and the Welsh Dee
Creators: name: Vernon Woolland, John
Publisher: name: University of Liverpool Repository
Year: 2023

description: The studies presented in this thesis were undertaken on a Water Resources Board grant, under the supervision of Dr. J .W. Jones, 0.B.E. at the University of Liverpool. The work: carried out formed part of a long term investigation into the effects of river regulation on aquatic organisms in the Welsh Dee and its tributaries. At the time of presentation of this thesis the Water Resources Board research programme is in its first stage, that is a detailed survey of the present biological, chemical and physica1 conditions prevailing in the River Dee. From an examination of these conditions predictions on the effects of further regulation may be possible, and data will be available for comparison with future" research(stage 2 of the research programme)' after the implementation of the proposed regulation . schemes. Results, obtained from the ,River, Dee, study will be used to, derive general formulae·app1icable·to any regulated river.
Litarachna denhami Lohmann 1909
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Pontarachnidae
Litarachna
Litarachna denhami

description: Litarachna denhami (Lohmann, 1909)
Records from the study area: Maharashtra (Arabian Sea)— Pešić et al. (2008); Andaman and Nicobar Islands (Andaman Sea)— Pešić et al. (2009).
Habitat: Marine littoral.
Distribution: Western Australia, Taiwan, Philippines, India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 32, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct
Creators: name: Bonkovsky, Herbert L.
name: Watkins, Paul B.
name: Serrano, Jose
name: Davern, Timothy
name: Chalasani, Naga
name: Rochon, James
name: Fontana, Robert J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Drug-induced liver injury (DILI) is an uncommon adverse drug reaction of increasing importance to the medical community, pharmaceutical industry, regulatory agencies and the general public.
title: On the metric theory of numbers in non-Archimedean settings
Creators: name: Lertchoosakul, Poj
Publisher: name: University of Liverpool Repository
Year: 2015

description: This thesis is a contribution to some fields of the metrical theory of numbers in non- Archimedean settings. This is a branch of number theory that studies and characterizes sets of numbers, which occur in a locally compact topological field endowed with a non- Archimedean absolute value. This is done from a probabilistic or measure-theoretic point of view. In particular, we develop new formulations of ergodicity and unique ergodicity based on certain subsequences of the natural numbers, called Hartman uniformly distributed sequences. We use subsequence ergodic theory to establish a generalised metrical theory of continued fractions in both the settings of the p-adic numbers and the formal Laurent series over a finite field. We introduce the a-adic van der Corput sequence which significantly generalises the classical van der Corput sequence. We show that it provides a wealth of examples of low-discrepancy sequences which are very useful in the quasi-Monte Carlo method. We use our subsequential characterization of unique ergodicity to solve the generalised version of an open problem asked by O. Strauch on the distribution of the sequence of consecutive van der Corput sequences. In addition to these problems in ergodic methods and number theory, we employ some geometric measure theory to settle the positive characteristic analogue of an open problem asked by R.D. Mauldin on the complexity of the Liouville numbers in the field of formal Laurent series over a finite field by giving a complete characterization of all Hausdorff measures of the set of Liouville numbers.
Spitzer as Microlens Parallax Satellite: Mass and Distance Measurements of Binary Lens System OGLE-2014-BLG-1050L
Creators: name: Zhu, Wei
name: Udalski, A.
name: Gould, A.
name: Dominik, M.
name: Bozza, V.
name: Han, C.
name: Yee, J. C.
name: Novati, S. Calchi
name: Beichman, C. A.
name: Carey, S.
name: Poleski, R.
name: Skowron, J.
name: Kozlowski, S.
name: Mroz, P.
name: Pietrukowicz, P.
name: Pietrzynski, G.
name: Szymanski, M. K.
name: Soszynski, I.
name: Ulaczyk, K.
name: Wyrzykowski, L.
name: Han, C.
name: Gaudi, B. S.
name: Pogge, R. W.
name: DePoy, D. L.
name: Jung, Y. K.
name: Choi, J. -Y.
name: Hwang, K. -H.
name: Shin, I. -G.
name: Park, H.
name: Jeong, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the first mass and distance measurement of a caustic-crossing binary system OGLE-2014-BLG-1050L using the space-based microlens parallax method. \emph{Spitzer} captured the second caustic-crossing of the event, which occurred $\sim$10 days before that seen from Earth. Due to the coincidence that the source-lens relative motion was almost parallel to the direction of the binary-lens axis, the four-fold degeneracy, which was known before only to occur in single-lens events, persists in this case, leading to either a lower-mass (0.2 $M_\odot$ and 0.07 $M_\odot$) binary at $\sim$1.1 kpc or a higher-mass (0.9 $M_\odot$ and 0.35 $M_\odot$) binary at $\sim$3.5 kpc. However, the latter solution is strongly preferred for reasons including blending and lensing probability. OGLE-2014-BLG-1050L demonstrates the power of microlens parallax in probing stellar and substellar binaries.
description: 29 pages, 8 figures, 4 tables; submitted to ApJ
title: Linear robust H-infinity stochastic control theory on the insurance premium-reserve processes
Creators: name: Yang, Lin
Publisher: name: University of Liverpool Repository
Year: 2015

description: This thesis deals with the stability analysis of linear discrete-time premium-reserve (P-R) systems in a stochastic framework. Such systems are characterised by a mixture of the premium pricing process and the medium- and long- term stability in the accumulated reserve (surplus) policy, and they play a key role in the modern actuarial literature. Although the mathematical and practical analysis of P-R systems is well studied and motivated, their stability properties have not been studied thoughtfully and they are restricted in a deterministic framework. In Engineering, during the last three decades, many useful techniques are developed in linear robust control theory. This thesis is the first attempt to use some useful tools from linear robust control theory in order to analyze the stability of these classical insurance systems. Analytically, in this thesis, P-R systems are first formulated with structural properties such that time-varying delays, random disturbance and parameter uncertainties. Then as an extension of the previous literature, the results of stabilization and the robust H-infinity control of P-R systems are modelled in stochastic framework. Meanwhile, the risky investment impact on the P-R system stability condition is shown. In this approach, the potential effects from changes in insurer's investment strategy is discussed. Next we develop regime switching P-R systems to describe the abrupt structural changes in the economic fundamentals as well as the periodic switches in the parameters. The results for the regime switching P-R system are illustrated by means of two different approaches: markovian and arbitrary regime switching systems. Finally, we show how robust guaranteed cost control could be implemented to solve an optimal insurance problem. In each chapter, Linear Matrix Inequality (LMI) sufficient conditions are derived to solve the proposed sub-problems and numerical examples are given to illustrate the applicability of the theoretical findings.
title: The clinical pharmacology of artemisinin based drug combinations
Creators: name: Muangnoicharoen, Sant
Publisher: name: University of Liverpool Repository
Year: 2023

description: This thesis focuses on the clinical efficacy, pharmacokinetics and pharmacodynamics of artemisinin based drugs and their combinations for their treatment of P. falciparu11l malaria. The aims of the thesis are to get a better understanding of the basic pharmacology of artemisinin type drugs and their combinations. Chapter I is introduction and general knowledge about malaria disease, antimalarial drugs, treatment and drugs resistance. Chapter 2 determines parasite drug susceptibility and drug interaction of dihydroartemisinin and the quinoline type drug, piperaquine, used together as a fixed dose drug combination against P. falciparu11l in vitro. The results show that P. falciparu11l is highly susceptible to these two drugs even though when used in combination they show slight antagonism. Using a set of genetically manipulated parasites the data also showed a clear role for mutations in pferl to confer cross resistance to piperaquine and chloroquine. Chapter 3 focuses on the development of methods to accurately measure artesunate and dihydroartemisinin levels in human plasma. The method was highly sensitivity, robust and importantly reproducible. This method was subsequently used for th.e measurement of artemisinin type drug concentrations throughout my research.
Digital Drug Safety Surveillance: Monitoring Pharmaceutical Products in Twitter
Creators: name: Dasgupta, Nabarun
name: Freifeld, Clark C.
name: Brownstein, John S.
name: Filice, Ross
name: Bao, Wenjie
name: Menone, Christopher M.
name: Kass-Hout, Taha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundTraditional adverse event (AE) reporting systems have been slow in adapting to online AE reporting from patients, relying instead on gatekeepers, such as clinicians and drug safety groups, to verify each potential event. In the meantime, increasing numbers of patients have turned to social media to share their experiences with drugs, medical devices, and vaccines.ObjectiveThe aim of the study was to evaluate the level of concordance between Twitter posts mentioning AE-like reactions and spontaneous reports received by a regulatory agency.MethodsWe collected public English-language Twitter posts mentioning 23 medical products from 1 November 2012 through 31 May 2013. Data were filtered using a semi-automated process to identify posts with resemblance to AEs (Proto-AEs). A dictionary was developed to translate Internet vernacular to a standardized regulatory ontology for analysis (MedDRA®). Aggregated frequency of identified product-event pairs was then compared with data from the public FDA Adverse Event Reporting System (FAERS) by System Organ Class (SOC).ResultsOf the 6.9 million Twitter posts collected, 4,401 Proto-AEs were identified out of 60,000 examined. Automated, dictionary-based symptom classification had 72% recall and 86% precision. Similar overall distribution profiles were observed, with Spearman rank correlation rho of 0.75 (p<0.0001) between Proto-AEs reported in Twitter and FAERS by SOC.ConclusionPatients reporting AEs on Twitter showed a range of sophistication when describing their experience. Despite the public availability of these data, their appropriate role in pharmacovigilance has not been established. Additional work is needed to improve data acquisition and automation.
title: Gene expression profiling of metastatic gastric cancer
Creators: name: Marie Pierre Paon, Lenaic
Publisher: name: University of Liverpool Repository
Year: 2023

description: Gastric cancer is one of the main cancers in the world, and is responsible for a large number of deaths each year. In Europe, the main issue is that it is only detected at latter stages, when metastases have developed. Although metastasis is the main cause of death from such tumours, the process is a very complex one and still not fully understood. In order to unravel this mechanism, microarrays have been used to study the expression pattern of a large number of genes in primary tumours and metastatic samples. These studies aim at indentifying genes that may playa role in metastasis. A number of microarray studies have already been carried out on gastric cancer to pursue knowledge. However, they have been mainly carried out in Asian populations, which are thought to present different gastric tumours than Europeans, possibly due to genetic and environmental parameters. The present thesis therefore aimed to carry out the first microarray study on gastric tumours from a European population, to identify genes that might playa role in gastric cancer metastasis, and assess whether there were any differences between Asian and European samples. In order to achieve this aim, the printing of in-house microarrays and methods to amplify and hybridise the samples first needed to be developed. This included the development of a new amplification method, the SMARTff7 protocol. Results showed that this method allowed more genes to be amplified than with an .established protocol. In addition, a microarray study published in 2003 identified a metastasis specific gene expression signature that could differentiate between metastatic and nonmetastatic primary tumours from different sites. However, this study did not include samples from gastric cancer. It was thus decided to test whether this signature could be applied to primary gastric tumours, using the new MetriGenixÃ‚Â® platform. Although the analysis seemed to indicate that the signature did not apply to gastric tumours, technical issues meant that the results were inconclusive. On the other hand, a larger microarray analysis using the techniques developed during this project allowed the indentification of a number of genes of interest which may playa role in the metastatic spread of gastric cancer.
title: Molecular epidemiology of lung cancer in the Liverpool lung project (LLP) cohort
Creators: name: De Souza, Nicosha
Publisher: name: University of Liverpool Repository
Year: 2015

description: The primary aim of the project was to evaluate the epidemiological and genetic susceptibility factors associated with lung cancer, in the Liverpool Lung Project (LLP) population. The associated datasets available for research with the LLP dataset (questionnaire) were: Office of National Statistics (ONS), Health Episode Statistics (HES) data with comorbidity data, single nucleotide polymorphism (SNP) data of 570 cases from Liverpool, 3000 controls from the 1958 Birth Cohort. The epidemiological (HES) data was used to study the effect of Charlson (CCI) and Elixhauser comorbidity index (ECI) on the incidence of lung cancer using the Cox proportional hazard regression and use the same HES data to design a 5-year sex specific incidence model for lung cancer with crucial covariates. The ECI and CCI were significant in both univariate and multivariate analyses adjusted for age at the start of the study, sex and smoking pack years. The developed models had a good discriminatory power (AUCmale = 0.73; AUCfemale = 0.77) when internally validated using a 10-fold cross validation. The genetic data for the LLP lung cancer cases was used in several contexts: i) to identify SNPS associated with lung cancer under a range of allelic models (additive, dominant, recessive and genotypic), using the Wellcome trust 1958 Birth Cohort as a control dataset; ii) to identify SNPs associated with cause specific and overall survival in lung cancer patients, utilising the Cox proportional hazard model with adjustment for various covariates; and iii) to identify gene pathways that are associated with lung cancer survival using the random forest survival method. SNPs within the genes PRDM11, ZNF382 and HMGA2 were identified in the genome wide case-control study when using the additive, dominant or genotypic models, whereas the recessive model identified the gene ITIH2. Significant SNPs (p≤10-6) associated with cause-specific survival in early stage cases were rs10230420 (WIPF3), rs3746619 and rs3827103 (both in MC3R). In advanced stage cases, significant SNPs were rs1868110 (NEK10) and rs2206779 (AF357533). For the overall survival analysis, significant SNPs were rs10230420 (WIPF3), rs2056533 (ZBTB20) and rs6708630 (CYS1) in early stage cases, whereas rs1868110 (NEK10) and rs2206779 (AF357533) were significantly associated with overall survival in advanced stage NSCLC cases. The pathway analysis using the random survival forest method was undertaken on 18 pathways for both cause-specific and overall survival of lung cancer cases. The results were consistent with apoptosis, base excision repair and mismatch repair being pathways influencing survival.
The origin, evolution and signatures of primordial magnetic fields
Creators: name: Subramanian, Kandaswamy
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The universe is magnetized on all scales probed so far. On the largest scales, galaxies and galaxy clusters host magnetic fields at the micro Gauss level coherent on scales up to ten kpc. Recent observational evidence suggests that even the intergalactic medium in voids could host a weak $\sim 10^{-16}$ Gauss magnetic field, coherent on Mpc scales. An intriguing possibility is that these observed magnetic fields are a relic from the early universe, albeit one which has been subsequently amplified and maintained by a dynamo in collapsed objects. We review here the origin, evolution and signatures of primordial magnetic fields. After a brief summary of magnetohydrodynamics in the expanding universe, we turn to magnetic field generation during inflation and other phase transitions. We trace the linear and nonlinear evolution of the generated primordial fields through the radiation era, including viscous effects. Sensitive observational signatures of primordial magnetic fields on the cosmic microwave background, including current constraints from Planck, are discussed. After recombination, primordial magnetic fields could strongly influence structure formation, especially on dwarf galaxy scales. The resulting signatures on reionization, the redshifted 21 cm line, weak lensing and the Lyman-$α$ forest are outlined. Constraints from radio and $γ$-ray astronomy are summarized. Astrophysical batteries and the role of dynamos in reshaping the primordial field are briefly considered. The review ends with some final thoughts on primordial magnetic fields.
description: 57 pages, 12 figures, Invited review for Reports on Progress in Physics, in Press