cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells
Creators: name: Abdelsalam, Mohamed
name: Zmyslia, Mariia
name: Schmidtkunz, Karin
name: Vecchio, Anita
name: Hilscher, Sebastian
name: Ibrahim, Hany S.
name: Schutkowski, Mike
name: Jung, Manfred
name: Jessen-Trefzer, Claudia
name: Sippl, Wolfgang
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 572

description: Although histone deacetylase (HDAC) inhibitors show promise in treating various types of hematologic malignancies, they have some limitations, including poor pharmacokinetics and off-target side effects. Prodrug design has shown promise as an approach to improve pharmacokinetic properties and to improve target tissue specificity. In this work, several bioreductive prodrugs for class I HDACs were designed based on known selective HDAC inhibitors. The zinc-binding group of the HDAC inhibitors was masked with various nitroarylmethyl residues to make them substrates of nitroreductase (NTR). The developed prodrugs showed weak HDAC inhibitory activity compared to their parent inhibitors. The prodrugs were tested against wild-type and NTR-transfected THP1 cells. Cellular assays showed that both 2-nitroimidazole-based prodrugs 5 and 6 were best activated by the NTR and exhibited potent activity against NTR-THP1 cells. Compound 6 showed the highest cellular activity (GI50 = 77 nM) and exhibited moderate selectivity. Moreover, activation of prodrug 6 by NTR was confirmed by liquid chromatography-mass spectrometry analysis, which showed the release of the parent inhibitor after incubation with Escherichia coli NTR. Thus, compound 6 can be considered a novel prodrug selective for class I HDACs, which could be used as a good starting point for increasing selectivity and for further optimization.
Constraining accretion signatures of exoplanets in the TW Hya transitional disk
Creators: name: Uyama, Taichi
name: Tanigawa, Takayuki
name: Hashimoto, Jun
name: Tamura, Motohide
name: Aoyama, Yuhiko
name: Brandt, Timothy D.
name: Ishizuka, Masato
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present a near-infrared direct imaging search for accretion signatures of possible protoplanets around the young stellar object (YSO) TW Hya, a multi-ring disk exhibiting evidence of planet formation. The Pa$β$ line (1.282 $μ$m) is an indication of accretion onto a protoplanet, and its intensity is much higher than that of blackbody radiation from the protoplanet. We focused on the Pa$β$ line and performed Keck/OSIRIS spectroscopic observations. Although spectral differential imaging (SDI) reduction detected no accretion signatures, the results of the present study allowed us to set 5$σ$ detection limits for Pa$β$ emission of $5.8\times10^{-18}$ and $1.5\times10^{-18}$ erg/s/cm$^2$ at 0\farcs4 and 1\farcs6, respectively. We considered the mass of potential planets using theoretical simulations of circumplanetary disks and hydrogen emission. The resulting masses were $1.45\pm 0.04$ M$_{\rm J}$ and $2.29 ^{+0.03}_{-0.04}$ M$_{\rm J}$ at 25 and 95 AU, respectively, which agree with the detection limits obtained from previous broadband imaging. The detection limits should allow the identification of protoplanets as small as $\sim$1 M$_{\rm J}$, which may assist in direct imaging searches around faint YSOs for which extreme adaptive optics instruments are unavailable.
description: 6 pages, 3 figures, accepted for publication in AJ
Additional file 1 of Factorial structure and measurement invariance of the Chinese version of the Oral Health Impact Profile-14 among clinical populations and non-clinical populations: an evidence for public oral investigations
Creators: name: Yang, Guang-Hui
name: Feng, Yao
name: Xue, Lan-Xin
name: Ou-Yang, Ze-Yue
name: Yang, Yi-Fan
name: Zhao, Ya-Qiong
name: Zhao, Jie
name: Hu, Jing
name: Ye, Qin
name: Su, Xiao-Lin
name: Chen, Ning-Xin
name: Zhong, Meng-Mei
name: Feng, Yun-Zhi
name: Guo, Yue
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Supplementary Material 1
The circular economy growth machine : a critical perspective on "post‐growth" and "pro‐growth" circularity approaches
Creators: name: Schultz, Felix Carl
name: Pies, Ingo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 330

description: This forum article contributes to the prospering debate in the circular economy (CE) community discussing whether—and to what extent—the CE is reconcilable with economic growth. Within this discourse about a functional CE, there exist two contesting perspectives. One argues in favor of pro-growth circularity, the other in favor of post-growth circularity. The aim of this article is to develop a line of argumentation that helps in reconciliating the two seemingly antagonistic perspectives. Toward that end, this article applies the method of “practical syllogism” that is well known in moral philosophy, since it can enlighten how normative and positive arguments can be structured to enable the formulation of well-justified moral conclusions. With the help of this interdisciplinary impulse, the article aims at detecting logical errors in current reasoning and fostering discursive learning processes. The ensuing arguments provide vital implications on the macro level by highlighting four critical elements to facilitate a CE transition, namely an intensive growth trajectory, an internalization of negative externalities through creating (missing) markets, an institutional encouragement of spreading positive externalities, and a diffusion of rents from innovation to society by taking the profit motive into service for enabling sustainability goals. Complementarily, the article provides implications on the micro level by highlighting the necessity to develop supplementary management competencies, namely governance competence to realize argumentative clarification and governance competence to (re-)configurate institutional structures. This article may serve as an incubator to ease new ways of thinking into academia and practice.
ВЛИЯНИЕ РЕАЛЬНЫХ И «ВИРТУАЛЬНЫХ» БИЗНЕС-ПРОЦЕССОВ НА СОЦИАЛЬНО-ЭКОНОМИЧЕСКУЮ ЭФФЕКТИВНОСТЬ ДИСТАНЦИОННОЙ ТОРГОВЛИ
Creators: name: Г. Г. Иванов
name: В. А. Матосян
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: дистанционная торговля
торговая организация
бизнес-процессы в торговых организациях
«виртуальные» и реальные бизнес процессы
инфраструктура
продвижение товаров
системы оплаты товаров
экономическая политика и стратегия
товародвижение

description: В современной экономике все большее значение приобретает использование дистанционных технологий. Данное положение полностью относится и к торговле. Часто online торговля рассматривается как дополнение к традиционным формам торговли. Все более широкое распространение получают различные внемагазинные формы организации торгового бизнеса, в частности, торговля посредством сети Интернет. Торговые организации рассматривают online торговлю как возможность увеличить количество каналов сбыта, и, вообще, как постоянно растущий рынок, позволяющий существенно увеличить объемы продаж при одновременной оптимизации затрат. Одним из основных факторов, предопределяющих выгодность online торговли, является наличие «виртуальных» бизнес-процессов, которые существенно сокращают общую сумму затрат торговли, делая удобным эту разновидность торговли для потребителей. Тем самым, через проявление некоторых характеристик социально-экономической результативности достигается экономическая эффективность.
Additional file 10: of Comparative genomics of the wheat fungal pathogen Pyrenophora tritici-repentis reveals chromosomal variations and genome plasticity
Creators: name: Moolhuijzen, Paula
name: Pao See
name: Hane, James
name: Gongjun Shi
name: Zhaohui Liu
name: Oliver, Richard
name: Moffat, Caroline
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Mitochondrial cob gene analysis. A) M4 mitochondrial cob gene spans 12 kb (26–39 kb) with intron spans greater than 2 kb. B) Mitochondrial cytochrome b protein multiple sequence alignment for Zymoseptoria tritici (AAP81933), Ptt (DQ919067.1), Ptr (GenBank DQ919068), SN79_contig_2277, SN4_contig_1698, SN15 (NC_009746), 11,137_00499, 134 _00534, 5213_00542, 86-124_00253, AR CrossB10_00129, DW5_00657, M4_00017, Ptt (NW_00352501 and 00356055), and BFP (DS231662.1) shows three known mutation sites for fungicide resistance. (PDF 102 kb)
Off-Line, Multi-Detector Intensity Interferometers I: Theory
Creators: name: Ofir, Aviv
name: Ribak, Erez N.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Stellar amplitude interferometry is limited by the need to have optical distances fixed and known to a fraction of the wavelength. We suggest reviving intensity interferometry, which requires hardware which is many orders of magnitude less accurate, at the cost of more limited sensitivity. We present an algorithm to use the very high redundancy of a uniform linear array to increase the sensitivity of the instrument by more than a hundredfold. When using an array of 100 elements, each almost 100m in diameter, and conservative technological improvements, we can achieve a limiting magnitude of about mb=14.4. Digitization, storage, and off-line processing of all the data will also enable interferometric image reconstruction from a single observation run, and application of various algorithms at any later time. Coronagraphy, selectively suppressing only the large scale structure of the source, can be achieved by specific aperture shapes. We conclude that after three decades of abandonment optical intensity interferometry deserves another review.
description: The article has been accepted for publication in MNRAS
Conflicts in urban peripheries in Europe
Creators: name: Kleemann, Janina
name: Struve, Berenike
name: Spyra, Marcin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 355

description: Urbanization is a global trend which is taking place at the costs of agricultural, forest, and other natural or semi-natural areas. As a result of urbanization, transitioning zones in urban peripheries located between urban and rural areas have a mixed character from a spatial, ecological, socio-demographic, and economic point of view. Different land use mixes and interests exist there in parallel and cause tensions and conflicts. In our research, we aimed at investigating the specific characteristics of conflicts in urban peripheries across Europe, showing striking examples and discussing possible recommendations for policy and planning addressing those conflicts. A structured literature review of 94 papers was conducted. The findings reflected a huge diversity in locations, contexts, and methods. Conflicts in urban peripheries in Europe is an interdisciplinary topic that is handled by social as well as natural sciences. We have identified four main conflict categories in urban peripheries: (a) land-use conflicts that relate to diverging interest in land use, (b) socio-economic conflicts that related to social aspects emerging between governance actors and different economic interests, (c) ethnic conflicts that related to race, religion, and custom, and (d) human-wildlife conflicts. The majority of papers were found in the category of land-use conflicts in urban peripheries. The main conflict topics in urban peripheries were related to socio-economic imbalances, house construction, and ethnic differences. Several types of governance actors and conflict topics could be assigned to each conflict category showing the variety in this context. A general recommendation to mitigate conflicts in urban peripheries could be a combination of various top-down and bottom-up policy and planning approaches, consulted and implemented by the governance actors who have been sensitized for the different viewpoints.
Role of three-particle vertex within dual fermion calculations
Creators: name: Ribic, T.
name: Gunacker, P.
name: Iskakov, S.
name: Wallerberger, M.
name: Rohringer, G.
name: Rubtsov, A. N.
name: Gull, E.
name: Held, K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate the influence of self-energy diagrams beyond the two-particle vertex level within dual fermion theory. Specifically, we calculate the local three-particle vertex and construct from it selected dual fermion self-energy corrections to dynamical mean field theory. For the two-dimensional Hubbard model, the thus obtained self-energy corrections are small in the parameter space where dual fermion corrections based on the two-particle vertex only are small. However, in other parts of the parameter space, they are of a similar magnitude and qualitatively different from standard dual fermion theory. The high-frequency behaviour of the self-energy correction is - surprisingly - even dominated by corrections stemming from the three-particle vertex.
title: 02_1810
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
КОММЕРЦИАЛИЗАЦИЯ НАУЧНО-ТЕХНИЧЕСКОЙ ДЕЯТЕЛЬНОСТИ КАК ГЛАВНЫЙ ФАКТОР РЕАЛИЗАЦИИ ИННОВАЦИОННОГО ПОТЕНЦИАЛА ВУЗА
Creators: name: А. Г. Изотова
name: Н. А. Литвинова
name: А. А. Токарев
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: инновационный потенциал
научно-техническая деятельность
вуз
коммерциализация
инновации
реализация

description: В данной статье рассматривается процесс коммерциализации результатов научно-технической деятельности, как главный фактор реализации инновационного потенциала вуза. Проанализировано понятие инновационного потенциала вуза и составляющих его элементов. Отражена взаимосвязь между компонентами, входящими в инновационный потенциал вуза. Авторами приведено определение научно-технической деятельности и ее результатов. Также в статье описаны формы коммерциализации научно-технической деятельности.
On Complexity Growth in Minimal Massive 3D Gravity
Creators: name: Qaemmaqami, Mohammad M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the complexity growth by using complexity = action (CA) proposal in Minimal Massive 3D Gravity(MMG) model which is proposed for resolving the bulk-boundary clash problem of Topologically Massive Gravity(TMG). We observe that the rate of the complexity growth for BTZ black hole saturates the proposed bound by physical mass of the BTZ black hole in the MMG model, when the angular momentum parameter and the inner horizon of black hole goes to zero.
description: 12 pages, Minor corrections, References added, Version to appear in PRD
Exploring the acquaintanceship effect for the accuracy of judgments of traits and profiles of adult playfulness
Creators: name: Brauer, Kay
name: Sendatzki, Rebekka
name: Proyer, René T.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 150

description: Objective: We aimed to extend the research on the interpersonal perception of adult playfulness (global and facets: Other- directed, Lighthearted, Intellectual, and Whimsical [OLIW]) by testing whether judgmental accuracy relates to indi-cators of acquaintanceship.Background: Playfulness has been found to contribute to social relationships.Method: Using data from 658 dyads (1,318 participants) who had been acquainted for 1 month to 62.2 years, we computed measurement invariance analyses and self–other agreement (SOA) for the facets and profiles of playfulness. We operational-ized acquaintanceship as length of acquaintanceship, relationship type (friends, family, and partners), and intensity of acquaintanceship. We tested acquaintance-ship effects with multigroup latent analyses and response surface analyses.Results: Self- and other ratings of playfulness showed scalar measurement in-variance and robust SOA in traits and distinctive profiles (≥ .37). There was only minor evidence for acquaintanceship effects for relationship duration (only Intellectual playfulness), and group comparisons showed that friends yielded lower SOA in profiles than dyads of family members and couples.Conclusion: Considering that playfulness can be accurately perceived even at zero acquaintance, we discuss whether playfulness is a “good trait” (high trait visibility) in which acquaintanceship plays a minor role. We also discuss methodological consid-erations for detecting acquaintanceship effects during relationship formation..
title: ADCO, Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Cart. 198-01 (11 H 1055), 185 folios, f. 0039
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0039, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les domaines de Saint-Jean de Losne et Losne (XVIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 198-01 (11 H 1055), 185 folios, f. 0039, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Stakeholder theory : exploring systems-theoretic and process-philosophic connections
Creators: name: Valentinov, Vladislav
name: Roth, Steffen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 330

description: Modern stakeholder theory is premised on the ‘integration thesis’, according to which business and ethics constitute an inseparable unity. For many management scholars, this thesis raised the difficult question of how far business can pursue ethical goals without losing its functional autonomy. We address this question by interpreting the integration thesis as the Luhmannian ‘unity of difference’ of business and ethics. This interpretation allows business and ethics to remain conceptually distinct, yet takes their very distinction to constitute a logical and dialectical unity as envisioned by the integration thesis. To justify this interpretation, we draw on the Luhmannian systems theory which accentuates the precariousness of the environment faced by business corporations, and on process philosophy which underscores the unique human capacity to navigate this precariousness by following social norms of ethical behaviour. We argue that a key prerequisite of successful stakeholder management is the activation of this human capacity.
Non-trivial Fixed Points of The Renormalization Group in Six Dimensions
Creators: name: Seiberg, Nathan
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We start a systematic analysis of supersymmetric field theories in six dimensions. We find necessary conditions for the existence of non-trivial interacting fixed points. String theory provides us with examples of such theories. We conjecture that there are many other examples.
description: 6 pages, uses harvmac
УПРАВЛЕНИЕ ЧЕЛОВЕЧЕСКИМ КАПИТАЛОМ В ИНТЕРЕСАХ СОЦИАЛЬНОГО РАЗВИТИЯ
Creators: name: Д. Ф. Ишмуратова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: человеческий капитал
управление
социальное развитие
воспроизводство человеческого капитала

description: В статье рассматривается человеческий капитал с позиции управления его функционированием и развитием. Необходимость регулирования данных процессов связана с наличием противоречивых тенденций его формирования и использования, с участием в них множества субъектов с разнонаправленными интересами и возможностями, а также со значением человеческого капитала как важного ресурса социальноэкономического развития. В соответствии с видами человеческого капитала выделяются основные уровни управления им, и дается их характеристика.
Retrospective database analysis of cancer risk in patients with type 2 diabetes mellitus in China
Creators: name: He, Xiaoning
name: Shi, Lizheng
name: Wu, Jing
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Objective: To investigate the association between type 2 diabetes (T2D) and the risk of overall cancer and site-specific cancers in a Chinese population. Research design and methods: Tianjin Urban Employee Basic Medical Insurance database (2003–2014) was used to identify patients with newly onset T2D in 2009, patients with prevalent T2D prior to 2009, and general individuals without T2D. Overall and site-specific cancer incidence rates and incidence rate ratios relative to general population were calculated for both incident and prevalent T2D cohorts. Multivariate Cox proportional hazards models adjusting for baseline characteristics and potential bias were conducted. Subgroup analyses based on gender and age were further conducted. Results: For the year 2009, 21,208 patients with onset T2D (mean age 58.8 years; 48.1% female), 28,248 patients with prevalent T2D (mean age 63.7 years; 50.2% female) and 744,339 general individuals (mean age 43.2 years; 47.7% female) were identified. Controlling for confounders, diabetic patients had an overall 56%–59% higher risk of developing cancer, among which the highest risks by site were liver (adjusted hazard ratio [aHR] = 1.80–2.48), colorectal (aHR = 2.41–2.69) and stomach (aHR = 2.02–2.51) cancers (all p < .05). Patients with prevalent T2D had increased cancer risk in the pancreas (aHR = 4.52, p < .001). Female diabetic patients had increased risk in the kidneys (aHR = 3.22–3.31, p < .01). Patients aged between 50 and 59 years had the highest relative risk (90% higher), while the relative risk was the lowest among patients ≥70 (45% higher). Conclusion: Type 2 diabetes was associated with increased overall cancer risk led by liver, colorectal and stomach cancers. Patients with longer diabetes duration were associated with higher pancreatic cancer risk and female diabetic patients had a higher risk of kidney cancer.
Experimental observation of magnetic bobbers for a new concept of magnetic solid-state memory
Creators: name: Zheng, Fengshan
name: Rybakov, Filipp N.
name: Borisov, Aleksandr B.
name: Song, Dongsheng
name: Wang, Shasha
name: Li, Zi-An
name: Du, Haifeng
name: Kiselev, Nikolai S.
name: Caron, Jan
name: Kovács, András
name: Tian, Mingliang
name: Zhang, Yuheng
name: Blügel, Stefan
name: Dunin-Borkowski, Rafal E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The use of chiral skyrmions, which are nanoscale vortex-like spin textures, as movable data bit carriers forms the basis of a recently proposed concept for magnetic solid-state memory. In this concept, skyrmions are considered to be unique localized spin textures, which are used to encode data through the quantization of different distances between identical skyrmions on a guiding nanostripe. However, the conservation of distances between highly mobile and interacting skyrmions is difficult to implement in practice. Here, we report the direct observation of another type of theoretically-predicted localized magnetic state, which is referred to as a chiral bobber (ChB), using quantitative off-axis electron holography. We show that ChBs can coexist together with skyrmions. Our results suggest a novel approach for data encoding, whereby a stream of binary data representing a sequence of ones and zeros can be encoded via a sequence of skyrmions and bobbers. The need to maintain defined distances between data bit carriers is then not required. The proposed concept of data encoding promises to expedite the realization of a new generation of magnetic solid-state memory.
Additional file 1: of Prenatal mercury exposure and features of autism: a prospective population study
Creators: name: Golding, Jean
name: Dheeraj Rai
name: Gregory, Steven
name: Genette Ellis
name: Emond, Alan
name: Iles-Caven, Yasmin
name: Hibbeln, Joseph
name: Taylor, Caroline
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Table S1. Levels of maternal blood mercury above the 80th centile found with the proxies for mercury exposure as used in TableÂ 4. (DOCX 16 kb)
ЧЕЛОВЕЧЕСКИЙ КАПИТАЛ И ЭФФЕКТИВНОСТЬ ЗАНЯТОСТИ
Creators: name: Д. Ф. Ишмуратова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: человеческий капитал
рынок труда
эффективность занятости

description: Статья посвящена анализу взаимосвязи человеческого капитала и эффективности занятости, рассматриваемой в аспекте соответствия между спросом и предложением на рынке труда по профессионально-квалификационному признаку. Исследования и статистические данные показывают наличие дисбаланса на рынке труда, что говорит как о качестве человеческого капитала, так и об условиях и рациональности его использования.
Sparse quadratic classification rules via linear dimension reduction
Creators: name: Gaynanova, Irina
name: Wang, Tianying
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (stat.ML)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: We consider the problem of high-dimensional classification between the two groups with unequal covariance matrices. Rather than estimating the full quadratic discriminant rule, we propose to perform simultaneous variable selection and linear dimension reduction on original data, with the subsequent application of quadratic discriminant analysis on the reduced space. In contrast to quadratic discriminant analysis, the proposed framework doesn't require estimation of precision matrices and scales linearly with the number of measurements, making it especially attractive for the use on high-dimensional datasets. We support the methodology with theoretical guarantees on variable selection consistency, and empirical comparison with competing approaches. We apply the method to gene expression data of breast cancer patients, and confirm the crucial importance of ESR1 gene in differentiating estrogen receptor status.
АНАЛИЗ ЗАРУБЕЖНОГО ОПЫТА ПО ВЫЯВЛЕНИЮ ФАКТОРОВ, ВЛИЯЮЩИХ НА РАЗВИТИЕ ЭКСПОРТА ПРОДУКЦИИ СЕЛЬСКОХОЗЯЙСТВЕННЫХ ПРЕДПРИЯТИЙ
Creators: name: Т. А. Кадыров
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: факторы производства
продовольственная безопасность
глобальные цепочки создания добавленной стоимости
экспортный потенциал
информационные технологии

description: В статье рассматривается зарубежный опыт по выявлению факторов, влияющих на развитие экспорта сельскохозяйственных предприятий. Определены и сгруппированы факторы, которые положительно, либо отрицательно могут повлиять на экспорт предприятия. Основным элементом в данном случае является участие в глобальных цепочках добавленной стоимости, а определение возможностей участия в цепочки требует анализа, который можно осуществить используя SWОT-анализ. Так же отмечен один из важнейших факторов, как информационные технологии, при использовании которых, оптимально продвигается экспортная политика предприятия.
АНАЛИЗ ИСПОЛЬЗОВАНИЯ СПЕЦИАЛЬНЫХ НАЛОГОВЫХ РЕЖИМОВ В ЯРОСЛАВСКОЙ ОБЛАСТИ
Creators: name: М. А. Казалова
name: Н. Ю. Глубокова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: малый и средний бизнес; предпринимательство; специальные налоговые режимы; темп прироста
развитие

description: Малый и средний бизнес играет важную роль в сфере экономики. Данный сектор может способствовать развитию экономики, посредством создания новых рабочих мест, специализации в различных отраслях экономики, использовании локальных источников ресурсов. При этом на сегодняшний момент, малый и средний бизнес занимает малую долю рынка. В статье автором проанализировано состояние налогообложения малого и среднего предпринимательства Ярославской области. В частности, проанализированы основные показатели деятельности субъектов малого и среднего предпринимательства, такие как численность налогоплательщиков, обороты предприятий за 2016-2018 гг., а также проведен анализ налоговых поступлений и задолженности в бюджет по Ярославской области. Цель исследования заключается в анализе основных показателей субъектов малого бизнеса и их налогообложения в одном из регионов России – Ярославской области.
Capture Point Trajectories for Reduced Knee Bend using Step Time Optimization
Creators: name: Griffin, Robert J.
name: Bertrand, Sylvain
name: Wiedebach, Georg
name: Leonessa, Alexander
name: Pratt, Jerry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Traditional force-controlled bipedal walking utilizes highly bent knees, resulting in high torques as well as inefficient, and unnatural motions. Even with advanced planning of center of mass height trajectories, significant amounts of knee-bend can be required due to arbitrarily chosen step timing. In this work, we present a method that examines the effects of adjusting the step timing to produce plans that only require a specified amount of knee bend to execute. We define a quadratic program that optimizes the step timings and is executed using a simple iterative feedback approach to account for higher order terms. We then illustrate the effectiveness of this algorithm by comparing the walking gait of the simulated Atlas humanoid with and without the algorithm, showing that the algorithm significantly reduces the required knee bend for execution. We aim to later use this approach to achieve natural, efficient walking motions on humanoid robot platforms.
ГОСУДАРСТВЕННОЕ УПРАВЛЕНИЕ СИСТЕМОЙ ОБРАЗОВАНИЯ КАК ИНСТРУМЕНТ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО РАЗВИТИЯ РОССИИ
Creators: name: А. А. Карнаух
name: Л. В. Коваленко
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: система образования
государственной управление
органы управления сферой образования
государственная политика в области образования
образование
сфера образования

description: В статье раскрывается значимость государственного управления системой образования в Российской Федерации, а также рассматриваются принципы, особенности и органы государственного управления сферой образования. Анализируется процесс управления сферой образования, осуществляющийся органами власти трех уровней, также рассмотрена реализация управления образованием через стратегическое планирование. Проведен анализ процедур, включенных в государственную регламентацию образовательной деятельности в Российской Федерации.
The Effect of Pair Cascades on the High-Energy Spectral Cutoff in Gamma-Ray Bursts
Creators: name: Gill, Ramandeep
name: Granot, Jonathan
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The highly luminous and variable prompt emission in Gamma-Ray Bursts (GRBs) arises in an ultra-relativistic outflow. The exact underlying radiative mechanism shaping its non-thermal spectrum is still uncertain, making it hard to determine the outflow's bulk Lorentz factor $Γ$. GRBs with spectral cutoff due to pair production ($γγ\to e^+e^-$) at energies $E_c\gtrsim10\;$MeV are extremely useful for inferring $Γ$. We find that when the emission region has a high enough compactness, then as it becomes optically thick to scattering, Compton downscattering by non-relativistic $e^\pm$-pairs can shift the spectral cutoff energy well below the self-annihilation threshold, $E_{\rm sa}=Γm_ec^2/(1+z)$. We treat this effect numerically and show that $Γ$ obtained assuming $E_c=E_{\rm sa}$ can under-predict its true value by as much as an order of magnitude.
description: 5 pages, 3 figures, Accepted for publication in MNRAS Letters
Additional file 1: of Assessing air quality index awareness and use in Mexico City
Creators: name: Borbet, Timothy
name: Gladson, Laura
name: Cromar, Kevin
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Survey Questions (Spanish) (PDF 73Â kb)
Particle Detection Algorithms for Complex Plasmas
Creators: name: Mohr, Daniel P.
name: Knapek, Christina A.
name: Huber, Peter
name: Zaehringer, Erich
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: In complex plasmas, the behavior of freely floating micrometer sized particles is studied. The particles can be directly visualized and recorded by digital video cameras. To analyze the dynamics of single particles, reliable algorithms are required to accurately determine their positions to sub-pixel accuracy from the recorded images. Typically, straightforward algorithms are used for this task. Here, we combine the algorithms with common techniques for image processing. We study several algorithms and pre- and post-processing methods, and we investigate the impact of the choice of threshold parameters, including an automatic threshold detection. The results quantitatively show that each algorithm and method has its own advantage, often depending on the problem at hand. This knowledge is applicable not only to complex plasmas, but useful for any kind of comparable image-based particle tracking, e.g. in the field of colloids or granular matter.
Eigenvalues of the hermitian Wilson-Dirac operator and chiral properties of the domain-wall fermion
Creators: name: PACS Collaboration
name: Khan, A. Ali
name: Aoki, S.
name: Aoki, Y.
name: Burkhalter, R.
name: Ejiri, S.
name: Fukugita, M.
name: Hashimoto, S.
name: Ishizuka, N.
name: Iwasaki, Y.
name: Izubuchi, T.
name: Kanaya, K.
name: Kaneko, T.
name: Kuramashi, Y.
name: Manke, T.
name: Nagai, K. -I.
name: Noaki, J.
name: Okawa, M.
name: Shanahan, H. P.
name: Taniguchi, Y.
name: Ukawa, A.
name: Yoshié, T.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Chiral properties of QCD formulated with the domain-wall fermion (DWQCD) are studied using the anomalous quark mass m_{5q} and the spectrum of the 4-dimensional Wilson-Dirac operator. Numerical simulations are made with the standard plaquette gauge action and a renormalization-group improved gauge action. Results are reported on the density of zero eigenvalue obtained with the accumulation method, and a comparison is made with the results for m_{5q}.
description: Lattice 2000(Chiral Fermions), 4 pages, 6 eps figures, LaTeX(espcrc2.sty)
Safety and outcomes of different endovascular treatment techniques for anterior circulation ischaemic stroke in the elderly : data from the Imperial College Thrombectomy Registry
Creators: name: D'Anna, Lucio
name: Barba, Lorenzo
name: Abu Rumeileh, Samir
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background: Although previous studies investigated the main predictors of outcomes after endovascular thrombectomy (EVT) in patients aged 80 years and older, less is known about the impact of the procedural features on outcomes in elderly patients. The aim of this study was to investigate the influence of EVT technical procedures on the main 3-month outcomes in a population of patients aged 80 years and older. Methods: This observational, prospective, single-centre study included consecutive patients with acute LVO ischaemic stroke of the anterior circulation. The study outcomes were functional independence at 3 months after EVT (defined as a mRS score of 0–2), successful reperfusion (mTICI ≥ 2b), incidence of haeamorrhagic transformation, and 90-day all cause of mortality. Results: Our cohort included 497 patients with acute ischaemic stroke due to LVO treated with EVT. Among them, 105 (21.1%) patients were aged ≥ 80 years. In the elderly group, multivariable regression analysis showed that thromboaspiration technique vs stent-retriever was the single independent predictor of favourable post-procedural TICI score (OR = 7.65, 95%CI = 2.22–26.32, p = 0.001). Conclusions: Our study suggests that EVT for LVO stroke in the elderly could be safe. The use of thromboaspiration was associated with positive reperfusion outcome in this population. Further studies in larger series are warranted to confirm the present results and to evaluate the safety and efficacy of EVT in the elderly and oldest adults.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 887
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 887, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 887, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Urinary peptidomic liquid biopsy for non-invasive differential diagnosis of chronic kidney disease
Creators: name: Mavrogeorgis, Emmanouil
name: He, Tianlin
name: Mischak, Harald
name: Latosinska, Agnieszka
name: Vlahou, Antonia
name: Schanstra, Joost Peter
name: Catanese, Lorenzo
name: Amann, Kerstin
name: Huber, Tobias
name: Beige, Joachim
name: Rupprecht, Harald D.
name: Siwy, Justyna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background and hypothesis: Specific urinary peptides hold information on disease pathophysiology, which, in combination with artificial intelligence, could enable non-invasive assessment of chronic kidney disease (CKD) aetiology. Existing approaches are generally specific for the diagnosis of single aetiologies. We present the development of models able to simultaneously distinguish and spatially visualize multiple CKD aetiologies. Methods: The urinary peptide data of 1850 healthy control (HC) and CKD [diabetic kidney disease (DKD), immunoglobulin A nephropathy (IgAN) and vasculitis] participants were extracted from the Human Urinary Proteome Database. Uniform manifold approximation and projection (UMAP) coupled to a support vector machine algorithm was used to generate multi-peptide models to perform binary (DKD, HC) and multiclass (DKD, HC, IgAN, vasculitis) classifications. This pipeline was compared with the current state-of-the-art single-aetiology CKD urinary peptide models. Results: In an independent test set, the developed models achieved 90.35% and 70.13% overall predictive accuracies, respectively, for the binary and the multiclass classifications. Omitting the UMAP step led to improved predictive accuracies (96.14% and 85.06%, respectively). As expected, the HC class was distinguished with the highest accuracy. The different classes displayed a tendency to form distinct clusters in the 3D space based on their disease state. Conclusion: Urinary peptide data present an effective basis for CKD aetiology differentiation using machine learning models. Although adding the UMAP step to the models did not improve prediction accuracy, it may provide a unique visualization advantage. Additional studies are warranted to further validate the pipeline's clinical potential as well as to expand it to other CKD aetiologies and also other diseases.
АКТУАЛЬНЫЕ ПРОБЛЕМЫ РАЗВИТИЯ КОРПОРАТИВНОЙ КУЛЬТУРЫ В ОРГАНИЗАЦИЯХ СФЕРЫ УСЛУГ
Creators: name: С. А. Климин
name: О. Н. Валькович
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: организационная культура
сфера услуг
управление персоналом
корпоративный дух

description: Статья посвящена актуальным проблемам развития корпоративной культуры в организациях сферы услуг. Авторами рассмотрены основные причины, по которым руководители организаций сферы услуг сталкиваются с трудностями при развитии организационной культуры. Определены основные направления возможного развития корпоративной культуры и предложены возможные пути устранения проблем развития корпоративной культуры в организациях сферы услуг.
Measuring Nuclear Spin Dependent Parity Violation With Molecules: Experimental Methods and Analysis of Systematic Errors
Creators: name: Altuntas, Emine
name: Ammon, Jeffrey
name: Cahn, Sidney B.
name: DeMille, David
Publisher: name: arXiv
Year: 2017
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Nuclear spin-dependent parity violation (NSD-PV) effects in atoms and molecules arise from $Z^0$ boson exchange between electrons and the nucleus, and from the magnetic interaction between electrons and the parity-violating nuclear anapole moment. It has been proposed to study NSD-PV effects using an enhancement of the observable effect in diatomic molecules [D. DeMille $\textit{et al.}$, Phys. Rev. Lett. $\textbf{100}$, 023003 (2008)]. Here, we demonstrate measurements of this type with sensitivity surpassing that of any previous atomic PV measurement, using the test system ${^{138}\mathrm{Ba^{19}F}}$. We show that systematic errors associated with our technique can be suppressed to at least the level of the present statistical sensitivity. With $\sim\!170$ hours of data, we measure the matrix element, $W$, of the NSD-PV interaction with uncertainty $δW/(2π)<0.7$ Hz, for each of two configurations where $W$ must have different signs. This sensitivity would be sufficient to measure NSD-PV effects of the size anticipated across a wide range of nuclei.
description: 25 pages, 15 figures, This longer article provides more details about our experimental techniques, measurement methods and analysis of the systematic uncertainty described briefly in the short version in arXiv:1801.05316
Off-Line, Multi-Detector Intensity Interferometers II: Implications and Applications
Creators: name: Ofir, Aviv
name: Ribak, Erez N.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Intensity interferometry removes the stringent requirements on mechanical precision and atmospheric corrections that plague all amplitude interferometry techniques at the cost of severely limited sensitivity. A new idea we recently introduced, very high redundancy, alleviates this problem. It enables the relatively simple construction (~1cm mechanical precision) of a ground-based astronomical facility able to transform a two-dimensional field of point-like sources to a three-dimensional distribution of micro-arcsec resolved systems, each imaged in several optical bands. Each system will also have its high resolution residual timing, high quality (inside each band) spectra and light curve, emergent flux, effective temperature, polarization effects and perhaps some thermodynamic properties, all directly measured. All the above attributes can be measured in a single observation run of such a dedicated facility. We conclude that after three decades of abandonment optical intensity interferometry deserves another review, also as a ground-based alternative to the science goals of space interferometers.
description: The article has been accepted for publication in MNRAS