cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rektor und Lehrer des Basler Gymnasiums in den 1870er Jahren
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1875
Subjects: Porträtfotografie
Burckhardt, Achilles1849-1892
Breitenstein, Jonas1828-1877

description: Gruppenbild des Lehrerkollegs des Gymnasiums am Münsterplat; obere Reihe, von links nach rechts: Aug. Beck (?), Otto Schäfer (?), Karl Völlmy Eduard Singeisen, Rudolf Burckhardt, Rudolf Stähelin; untere Reihe von links nach rechts: Felix Berholet, Karl Kienle, Nath. Plüss (?), Daniel Albert Fechter, Johann Rudolf Burckhardt (Rektor), Theophil Burckhardt, Friedrich Iselin, Achilles BUrckhardt, Jonas Breitenstein
description: C. Bretagne & David
description: Abzug auf eine Unterlage montiert
description: Titel und Datierung gemäss handschriftlicher Notiz auf der Rückseite der UNterlage
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Unterlage
RNA interference gene therapy for dominant photoreceptor degeneration disease in mouse models expressing mutant guanylate cyclase-activating protein 1
Creators: name: Jiang, Li
Publisher: name: University of Utah
Year: 2012
Subjects: RNA interference
Dominant photoreceptor degeneration disease
Mouse models
GUCA1A gene
Guanylate Cyclase Activator 1A gene
Cone dystrophy
Cone-rod dystrophy

description: Missense mutations in the GUCA1A (Guanylate Cyclase Activator 1A) gene, encoding the Ca2+-binding protein GCAP1 (Guanylate Cyclase Activating Protein 1), are  associated with autosomal dominant cone and cone-rod dystrophy. GCAP1 is involved in photoreceptor recovery after photoactivation, by regulating cGMP synthesis of guanylate cyclases through a Ca2+ feedback loop. The specific aims of my thesis were to: (1) identify novel GCAP1 mutations in human patients suffering from autosomal dominant cone and cone-rod dystrophy, and assay the biochemical properties of mutant GCAP1 in  vitro; (2) generate and characterize transgenic mice expressing mutant GCAP1; and (3) develop RNA interference gene therapy for the disease in the mouse models.  Two novel GCAP1 mutations, L151F and N104K, were identified from two autosomal dominant cone dystrophy families by genetic analysis. Biochemical analysis of  recombinant wild-type and mutant GCAP1 proteins expressed in insect cells indicates that the novel mutations altered the Ca2+- sensitivity of GCAP1 and persistently stimulate guanylate cyclases to synthesize cGMP even at the physiologic dark Ca2+ concentrations  at which GCAP1 is normally inactive. The resulting elevated levels of cGMP and Ca2+ in photoreceptors are predicted to cause retinal degeneration, providing a dominant gain-of-function mechanism leading to the disease.  Two transgenic mouse models expressing GCAP1 (L151F) and GCAP1 (N104K) were generated and presented late-onset and slowly progressive photoreceptor degeneration. They closely mimicked the human disease, suggesting that they are ideal  genetically manipulated mouse models for elucidating the underlying molecular mechanisms and developing therapeutic interventions for GCAP1 linked autosomal  dominant cone and cone-rod dystrophy.  Ablation of GCAPs in knockout mice did not result in any pathological effects. Therefore, we developed a strategy to knockdown both mutant and wild-type Guca1a  mRNA by RNA interference. Efficient GCAP1 short-hairpin (sh)RNAs were identified via an in vitro screening system and packaged into an effective self-complementary  adeno-associated viral vector, scAAV2/8, that produces shRNA in photoreceptors. A scAAV2/8-bG1shRNA was delivered to a rapidly degenerating mouse model  overexpressing bGCAP1 (Y99C) to demonstrate the therapeutic benefit of the strategy. The treated eyes showed a significant rescue from photoreceptor degeneration. Thus, this study demonstrated that RNAi gene therapy is a promising therapeutic tool for dominant  retinal diseases resulting from GCAP1 mutations.
Determination of Cadmium(II) by Differential Pulse Voltammetry (DPV) Using a Cerium(IV) Oxide: Polyaniline Composite Modified Glassy Carbon Electrode (GCE)
Creators: name: Altundal, Melis
name: Üğe, Ahmet
name: Gök, Özer
name: Zeybek, Bülent
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: A novel electrochemical sensing platform based on differential pulse voltammetry was prepared for selective determination of Cd(II). A glassy carbon electrode as the substrate and cerium (IV) oxide-polyaniline (CeO2-PANI) composite as the modification material were employed. Various structural and electrochemical methods characterized the CeO2-PANI composite and CeO2-PANI modified electrode. The CeO2-PANI composite modified electrode presented high electrocatalytic activity for the reduction of Cd(II) compared to CeO2 and PANI modified electrodes. The influence of the supporting electrolyte and pH of solution was investigated upon the analyte response, and the optimum conditions were determined. The CeO2-PANI composite modified electrode displayed a large linear range from 1.0 to 1000 μmol L−1 for Cd(II) with a limit of detection of 8.59 nmol L−1 in Britton-Robinson (B-R) buffer at pH 5.0. This electrode exhibited selectivity against other electroactive species such as Pb(II), Zn(II), and Cu(II). Furthermore, the designed electrochemical platform was successfully utilized to determine spiked Cd(II) in various samples, including honey, milk, and lake and tap water.
Lehrer des Unteren Gymnasiums Basel
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1889
Subjects: Porträtfotografie
Hotz, Rudolf1852-1917
Bucherer, Emil1852-1928
Löw, Rudolf1864-1930
Burckhardt, Fritz1830-1913
Rippas, Karl August1831-1906

description: Gruppenbild der Lehrer des Unteren Basler Gymnasiums (Humanistisches Gymnasium am Münsterplatz). Abgelichtet sind in der oberen Reihe (von links nach rechts): Heinrich Schäfer, Rudolf Hotz, Berthold Brömmel, Karl Grüninger, Albert Burckhardt, Emil Bucherer, Rudolf Löw. In der unteren Reihe (von links nach rechts): Hans Kestenholz, Hans Heusler, Eduard Singeiesen, Fritz Burckhardt (Rektor), Felix Bertholet, Karl Rippas, Hans Preiswerk
description: Unbekannte/ Fotograf/in
description: Abzug auf eine Kabinettkarte montiert
description: Datierung und Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Acompanhamento de Programas do Governo Federal na SFC
Creators: name: Rocha, Alexandre
Publisher: name: figshare
Year: 2020
Subjects: subject: 160509 Public Administration
subject: FOS: Political science

description: Este texto é parte da 5ª etapa do Projeto de Capacitação em Avaliação de Programas Públicos. O seu objetivo é sintetizar os dados levantados pelos AFCE-CE Alexandre Amorim Rocha (SEPLOM) e Marçal Roberto Ferreira de Freitas (SECON) junto à Secretaria-Adjunta para Assuntos de Fiscalização da Secretaria Federal de Controle, em visita feita em 29 e 30/08/96. Essa iniciativa insere-se na estratégia do TCU de buscar parcerias com outras instituições no campo em questão, aproveitando experiências e conhecimentos já existentes no país. [Informativo União]
[Doppelporträt des Ehepaars Hermann Wilhelm und Luise Schäfer-Raillard
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1890
Subjects: Porträtfotografie

description: Unbekannte/r Fotograf/in
description: Abzug auf einen Karton montiert
description: Datum und Name der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite des Kartons
Mutational analyses of members of the fibroblast growth factor family and Hoxa-9 during mouse development
Creators: name: Peterson, Cynthia Leigh
Publisher: name: University of Utah
Year: 2012
Subjects: Mice - Development
Mice - Genetics - Fibroblast growth factors
Transcription factors

description: The complex pattern of events that govern embryogenesis and subsequent development is regulated by an intricate interplay of polypeptide growth factors and transcription factors. The work presented in this dissertation has focused on the role of one family of polypeptide growth factors-the fibroblast growth factors (FGFs)--and one family of transcription factors--the Hox homeoproteins. Using gene targeting and transgene insertion we have shown that members of both families are important during development of the mouse. Previously it was shown that FGF-3 is involved in the formation of the tail and inner ear. We have found that FGF-4 is required during postimplantation for the survival of the embryo and that FGF-5 is a negative regulator of hair growth. While Fgf-3, Fgf-4 and Fgf-5 are expressed in numerous tissue types throughout embryogenesis, mice homozygous for a targeted disruption in these genes show defects in only a subset of these tissues. This, in addition to the observation that these genes are often expressed in overlapping or adjacent domains, suggests that they have overlapping or redundant functions which might only be revealed in double mutants. To address this possibility, we used targeted mutagenesis to generate mice with mutations in two or more of these genes. The analysis of mice with disruptions of both alleles of Fgf-3 and one allele of Fgf-4 revealed that FGF-3 and FGF-4 function synergistically during the development of the embryonic vasculature system and the external ear. The analysis of mice with disruptions in both Fgf-3 and Fgf-5 showed that FGF-3 and FGF-5 also cooperate in the formation and/or maintenance of the embryonic vasculature. To investigate the function(s) of one member of the Hox gene family, we functionally inactivated Hoxa-9 in the mouse using gene targeting. In addition, we overexpressed Hoxa-9 via transgene insertion. We show that the loss-of-function mutation results in anterior homeotic transformations whereas the gain-of-function mutation results in posterior homeotic transformations. Thus, a critical dosage of Hoxa-9 is important for correct specification of regional identity along the anterior-posterior body axis.
[Doppelporträt des Ehepaars Albert und Jenny von Speyr]
Creators: name: Taeschler-Signer, Carl
Publisher: name: [s.n.]
Year: 1880
Subjects: Porträtfotografie
Speyr, Albert von1848-1921

description: Taeschler-Signer
description: Abzug auf eine Kabinettkarte montiert
description: Name der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
[Doppelporträt des Alfred Stückelberg und seiner ersten Frau Alice, geborene von Breidenbach]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1903
Subjects: Porträtfotografie
Stückelberg, Alfred1870-1953

description: Unbekannte/r Fotograf/in
description: Abzug auf einen Karton montiert
description: Datierung und Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite des Kartons
Jahresberichte 1971-1976
Creators: name: Basler Handelskammer
Publisher: name: [s.n.]
Year: 1971

description: Enthält: Einzelhefte
description: Deutsch
description: Verzeichnung=Description=Inventaire 13.07.2017 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
description: Verzeichnung=Description=Inventaire 2019 ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert Martin Lüpold
Deconstruction of narratives and identification of hate speech. Refugees in the Academy Conference/Aulas refugio, September 2020
Creators: name: Hänninen, Liisa
Publisher: name: Zenodo
Year: 2022
Subjects: Discurso discriminativo, discurso de odio, migrantes, refugiados, incitación a violencia

description: In the current European societies, discriminative and hate discourse (hate speach) around the theme of migrants and refugees is becoming growingly popular. Research has shown that hate speech has considerable effects on the perception of image and acceptation of migrants, and it can foster violent acts. The present communication focuses on how to identify, classify and desconstruct diverese expressions of hate speech. Research methods and practices are explained from a theory perspective and practical examples are also provided.
description: Reduced brief public version of the course presentation
Jahresberichte 1966-1970
Creators: name: Basler Handelskammer
Publisher: name: [s.n.]
Year: 1966

description: Enthält: Einzelhefte
description: Deutsch
description: Verzeichnung=Description=Inventaire 13.07.2017 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
description: Verzeichnung=Description=Inventaire 2019 ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert Martin Lüpold
Prevalence and duration of breast feeding and weaning practices in Utah
Creators: name: Thomforde, Susan Louise Kaufman
Publisher: name: University of Utah
Year: 2012
Subjects: Breast feeding - Utah
Weaning - Utah
Breast feeding - Social aspects

description: This study analyzed the incidence of breast feeding and reasons for weaning among women in Utah.  A convience sample population of 274 was obtained from women who were 3 months to 1 year postpartum.  The time of weaning was found to be significantly associated with the following reasons for weaning:  breast and nipple problems (t=.760, p
Validated High-Performance Liquid Chromatographic (HPLC) Method for the Simultaneous Quantification of 2,3-Butanediol, Glycerol, Acetoin, Ethanol, and Phosphate in Microbial Cultivations
Creators: name: de Souza, Bruna Campos
name: Bossardi, Flávia Frozza
name: Furlan, Greice Ribeiro
name: Folle, Analia Borges
name: Reginatto, Caroline
name: Polidoro, Tomás Augusto
name: Carra, Sabrina
name: da Silveira, Mauricio Moura
name: Malvessi, Eloane
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The aim of this study was to validate an analytical method for the simultaneous quantification of 2,3-butanediol, glycerol, acetoin, ethanol and phosphate (PO43-) by high-performance liquid chromatography (HPLC) coupled with a refractive index detector. The validation was performed according to the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) - Guideline Q2 (R1). The parameters of linearity, limits of detection and quantification, precision and accuracy were evaluated. The accuracy was evaluated using standards solutions and a microbial cultivation sample. The linearity (r ≥ 0.99, n = 3) of the method was defined in the range from 0.18 to 2.52 g L−1 for phosphate (PO43-); 0.5 to 10.0 g L−1 for glycerol, acetoin and ethanol; 0.375 to 7.5 g L−1 for meso-2,3-butanediol; and 0.125 to 2.5 g L−1 for (S,S)- or (R,R)-2,3-butanediol. The limits of detection and quantification were below the concentration range used in the method. The average recovery rate, intra-day and inter-day precisions for all compounds were 98.71, 0.09 and 0.50%, respectively. The results for the accuracy ranged between 97.97 and 101.18% for all compounds in the standard solution. The method was demonstrated to be precise, specific, and reproducible for the quantification of all compounds evaluated, ensuring the reliability. Further, this method was successfully applied to samples from bioprocesses with low matrix effects and an average recovery of 99.55%.
The Aging Senegalese Diaspora in Milan. Successful Models, Return Trajectories, and Challenges of Elderly People between Senegal and Italy
Creators: name: Gardini, Marco
Publisher: name: Zenodo
Year: 2022

description: From the colonial period to the 1970s, France has been the main country of destination for the Senegalese diaspora. The French and Senegalese academic debate on migration has paid considerable attention to the mobilities connecting Senegal and the former colonial power, focusing on – among other things – how kinship structures and gender and generational roles have been reproduced or reconfigured in a transnational space deeply structured by longstanding cultures of migrations (see, for instance: Dia 2008, 2010, 2013; Diop 2008; Timera and Garnier 2010). In the late 1970s, when France started to implement more strict immigration policies, the Senegalese diaspora diversified its European destinations. Italy was one of them, and migrants from Senegal started to arrive in the 1980s, working mainly as street vendors but also contributing to an industrial system that was starting to shrink. Migrants of this first generation are now approaching or have reached retirement, have spent a large part of their lives in Italy, were joined by wives and had children in Italy, in many cases have obtained permanent residence permits or citizenship, and are now facing the many challenges connected to aging in a diasporic context.
[Doppelporträt des Ehepaars Karl und Clara Sarasin-Forcart]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1900
Subjects: Porträtfotografie
Sarasin, Karl1842-1917
Sarasin, Clara1848-1935

description: Abzug auf eine Kabinettkarte aufgezogen
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
description: Unbekannte/r Fotograf/in
Determination of Cisplatin Cross-Linked Hyaluronic Acid (CPHA) Hydrogel and DNA Using the Fluorescent Response from Mercaptopropionic Acid (MPA) Capped Cadmium Telluride Quantum Dots (CdTe QDs)
Creators: name: Jin, Penghui
name: Ma, Daoqing
name: Gao, Yabiao
name: Wang, Libin
name: Gao, Zhihong
name: Zhang, Yating
name: Liu, Mingxin
name: Xu, Jingying
name: Wang, Jidong
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A highly sensitive and dual-directional fluorescent sensing system was developed to detect both cisplatin prodrug cross-linked hyaluronic acid (CPHA) hydrogel (quencher) and DNA (receptor) based on mercaptopropionic acid (MPA) capped CdTe quantum dots (QDs). Different from the previous work for this platinum compound, a multifunctional delivery system, CPHA hydrogel, which was used to address the challenges in drug resistance and severe side effects, was prepared and accurately detected based on the synthesis of the cisplatin prodrug and fluorescence quenching of CdTe QDs resulting from photo-induced electron transfer. When DNA was conjugated with Pt ions in a system composed of CdTe QDs and CPHA hydrogel, the fluorescence of the system was recovered for the determination of DNA. This reversible “turn off–on” strategy presented a high sensitivity and low detection for CPHA hydrogel from 10 to 50 nM with a detection limit of 1.50 nM and DNA from 0 to 75 nM with a detection limit of 0.60 nM. This approach provides a novel direction for further study of the Pt based drug-load with reduced side effects and improved therapy efficacy, effective screening of anticancer drugs, and accurate determination of DNA at low concentrations.
[Doppelporträt des Ehepaars Karl und Clara Sarasin-Forcart]
Creators: name: Taeschler-Signer, Carl
Publisher: name: [s.n.]
Year: 1880
Subjects: Porträtfotografie
Sarasin, Clara1848-1935
Sarasin, Karl1842-1917

description: Taeschler, Photogr.
description: Der Abzug ist auf eine Kabinettkarte aufgezogen
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite
Private equity investment in banking organizations a policy review of regulatory responses to the financial crisis of 2008
Creators: name: Jensen, Ryan F.
Publisher: name: University of Utah
Year: 2012
Subjects: Mortgage crisis
Bank Holding Company Act

description: The financial crisis of 2008, a result of the 2007 subprime mortgage crisis and theensuing credit crunch, wreaked havoc among financial institutions in the United States and beyond. As a result, the health of these institutions have significantly deteriorated, increasing the risk to their counterparties and creating dramatic uncertainty in financial markets. The broader economy has entered into a recession as a result of this crisis, and bold regulatory action has been taken to help mitigate this crisis. One such effort by authorities has been to update existing regulatory policies surrounding the enforcement of the Bank Holding Company Act, which limited private equity investment in banking organizations. The purposes of this research project are (1) to analyze the regulatory responses taken in order to facilitate private equity investment in banking organizations, (2) to examine potential ways private equity and banking organizations might work together, as demonstrated by the private equity industry's record of success and by examining case studies of private equity investments in banking organizations, and (3) to draw conclusions as to the potential future of such investments and the effectiveness this will have on the banking industry. This thesis begins by providing background information on the credit and financial crises followed by a discussion of the potential impact of the crises on banking organizations. I then examine banking organizations' needs for capital and the potential role private equity investors might play provided policy changes. Next, I give a more detailed account of the specific provisions of the regulatory restrictions limiting private equity investments in banking organizations and alternative ways private equity firms have made investments in banking organizations. I then provide an analysis the revised policy statement. Next, I discuss further measures by federal regulators that would facilitate and provide some potential safety measures for private equity investments in banking organizations. I offer case studies of past private equity investments in banking organizations to foreshadow the potential ways private equity and banking organizations can work together under a more conducive regulatory framework. I speculate as to the future of private equity investment in banking organizations. Lastly, I present conclusions the role private equity investment might play in the troubled banking industry and the effectiveness of regulatory policy responses in this regard.
ROCR is an oscillating climbing robot: dynamically climbing sheer walls with a pendular two-link mass-shifting robot
Creators: name: Jensen-Segal, Samuel I
Publisher: name: University of Utah
Year: 2012
Subjects: Bio-inspired
Brachiation
Climbing robots
Dynamic climbing
Energy efficiency
Mechatronics

description: Driven by the need for lightweight, energy efficient, mission adaptable climbing robots, a new type of vertical wall climbing robot is developed. This thesis presents a novel bio-inspired dynamic climbing robot, with a recursive name: ROCR is an Oscillating Climbing Robot. ROCR is a pendular tow-link, serial chain robot that utilizes alternation hand-holds and an actuated tail to propel itself upward in a climbing style based on observation of human climbers and brachiating gibbons.
Studies on the structure of ATP-creatine transphosphorylase from calf muscle
Creators: name: Allison, Trenton Bruce
Publisher: name: University of Utah
Year: 2012
Subjects: Peptide Maps
Aminopeptidase

description: Identical amino acid composition and identical peptide map locus are sufficient criteria to establish the fact that two peptides are identical.  Comparison of homologous proteins can be made on the basis of composition analysis and peptide mapping of peptides prepared under identical conditions.  As a first step in the study of the homology of the isoenzymes of ATP-creatine transphosphorylase, the enzyme from the calf muscle was isolated and crystallized.  Peptides from a tryptic digestion were separated initially by AG 50W-X2 cation exchange chromatography and then purified as individual peptides from two dimensional paper electrophoresis and chromatography (peptide mapping).  Comparison of the peptide map on the original peptide mixture with that of the composite map indicated that not all peptides of the total tryptic digest can be resolved by peptide mapping; therefore, an initial separation of the peptides on AG 50W-X2 cation exchange resin allowed for purification of individual peptides from column fractions.  Composition analysis of each pure peptide was performed on 20 hour acid hydrolysates on an amino acid analyzer utilizing high sensitivity techniques.  The total amino acid composition of the enzyme was established, within experimental error, from the sum of the compositions of the individual peptides.  This composition was compared with the composition obtained from total amino acid analysis of acid hydrolysates and gave good correlation within the limits of experimental error.  Peptides containing S-carboxymethylcysteine, tryptophan and methionine were identified by amino acid composition and peptide map locus.  These three residues are invariant throughout the series of creatine kinase isoenzymes and the 15 peptides in which these residues are found contain 38% of the total amino acids.  The peptides containing S-carboxymethylcysteine are particularly important since enzymatic activity is associated with this residue.  Titration with sulfhydryl seeking reagents equivalent to two moles/mole of enzyme resulted in complete loss of enzymatic activity.  Comparison of the four (per subunit) S-carboxymethylcysteine containing peptides established, unequivocally, that the reactive sulfhydryl residue was contained in a 26 residue peptide, the sequence of at least a portion of this peptide is the same as similar peptides containing the reactive sulfhydryl residue in the rabbit and calf muscle enzymes and in the ox brain enzyme.  The techniques of purification and identification of the individual tryptic peptides from the calf muscle enzyme that were established in this study can be utilized to compare the similarities and differences of other creatine kinase isoenzymes to the calf muscle enzyme with as little as one micromole of crystalline enzyme.
Identification of Cellular Targets of Marine Natural Products
Creators: name: Veltri, Charles Anthony
Publisher: name: University of Utah
Year: 2012
Subjects: Natural Products
Marine Pharmacology

description: Proteases are found in all life forms and regulate many cellular pathways. Proteases  have been proven as viable drug targets. Chapter 1 reviews the mechanism of hydrolysis  of the amino acid based aspartic, cysteine, serine and threonine proteases. Chapter 1 also  highlights the current antiprotease therapeutics in the clinic.  Chapter 2 describes studies performed to better understand the mechanism of  deubiquitinating enzyme inhibition by the punaglandins, marine derived prostanoids. As  hypothesized, altering electronegativity of the a-carbon substituent of prostaglandin A2  derivatives modifies the activity of prostanoids. However, halogenation of the a-carbon  does not increase selectivity toward a specific deubiquitinating enzyme. Interestingly, the  iodinated prostaglandin A2 derivative was the most potent inhibitor. The iodinated  derivative was used to identify the site of adduct formation with deubiquitinating  enzymes. As hypothesized, the prostanoids interact with the active site of  deubiquitinating enzymes. The triply charged ions representing the tryptic fragments  containing the catalytic Cys were observed with addition of the prostanoid. The iodinated  derivative forms an adduct that results in the loss of iodine, but this is not a general  mechanism for all halogens. The chlorinated prostaglandin A2 derivative forms an adduct  but retains the halogen. The prostanoids were also tested for their ability to inhibit  ubiquitin ligation. The punaglandins and prostaglandin At derivatives do inhibit the  ubiquitination of p53, but the inhibition may be through different mechanisms. A triad  protein complex forms during punaglandin 2 treatment of the p53-ubiquitination sample  but not during treatment with the iodinated prostaglandin A2 derivative. Chapter 3 presents the identification of the chondropsins as potent inhibitors of the  Wnt signaling pathway and cellular proliferation. Their activity in the Wnt signaling  pathway was shown to be due to their inhibition of V-ATPases. Inhibition of V-ATPase  activity interrupts the recycling of Wntless, which decreases Wnt secretion. V-ATPase  inhibition was also shown to influence the mTOR pathway. Since V-ATPase inhibition  influenced both signaling pathways, the antiproliferative effects of the chondropsins are  most likely due to a combination of many targets rather than one specific target.
Toxemia, illness proneness and stress.
Creators: name: Reilly, Linda Ann
Publisher: name: University of Utah
Year: 2012
Subjects: Sick Role
Utah

description: This is a study of the relationships between illness proneness, life change stress, and toxemia of pregnancy.  Illness proneness, common pregnancy symptoms and life change stress data were obtained from the Utah-IIIC test battery developed and administered by the Pregnancy, Illness Proneness, and Stress (PIPAS) project of the University of Utah, College of Nursing.  Women enrolled in prenatal classes at McKay-Dee Hospital, Ogden, Utah, were given the Utah-IIIC test battery in the second to eight month of pregnancy.  The Illness Proneness (IP), Trimester Symptom, and Modified Schedule of Recent Experience (SRE) portions of the battery were used to measure general susceptibly to illness; pregnancy symptoms experienced per trimester; and life change stresses experienced during the previous 12 months, respectively.  Following delivery, medical record data were used to classify the women as toxemic or normal controls.  The sample consisted of 29 toxemic women and 137 normal controls.  No clinically significant differences were found between toxemic and normal group mean test scores and no relationships were found between the test scores and the incidence of toxemia, with one exception.  The Illness Proneness-SRE combined score for the entire 12-month period was related to the incidence of toxemia, p=.0124.  A higher percentage of toxemic women had high IP-SRE scores (7.2% vs. 1.5%) but the majority of both groups (79% and 69%) had low IP-SRE scores.  Discriminant analyses, using the Utah-IIIC test scores, were unable to produce functions able to differentiate between the groups, with any clinically useful degree of specificity or sensitivity.
Development of Poly(3,4-Ethylenedioxythiophene) (PEDOT) Electropolymerized Sorbent-Based Solid-Phase Microextraction (SPME) for the Determination of Parabens in Lake Waters by High-Performance Liquid Chromatography – Tandem Mass Spectrometry (HPLC-MS/MS)
Creators: name: Werner, Justyna
name: Rębiś, Tomasz
name: Frankowski, Robert
name: Grześkowiak, Tomasz
name: Zgoła-Grześkowiak, Agnieszka
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Parabens are widely used as antimicrobial preservatives in cosmetic products and pharmaceuticals. Therefore, their presence in the environment is considered to be serious and their determination is important. This paper reports the development and validation of a new method based on solid-phase microextraction (SPME) and high-performance liquid chromatography – tandem mass spectrometry (HPLC-MS/MS) for the simultaneous determination of five parabens (methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP) and benzylparaben (BzP)) in surface water. The polymer sorbent was obtained by the electropolymerization of 3,4-ethylenedioxythiophene on a stainless steel spring support. The parameters affecting the extraction efficiency of parabens were optimized. Under optimal conditions, the extraction recoveries ranged from 88 to 98% except for BzP (70%). Good linear responses were obtained with correlation coefficients (r2) exceeding 0.999. The detection limits were from 0.004 to 0.28 µg L−1. The method was successfully applied for the determination of parabens in lake water.
Investigating inertial measurement for human-scale motion tracking
Creators: name: Johnson, Eric Allen
Publisher: name: University of Utah
Year: 2012
Subjects: Accelerometer
Calibration
Gyro
Inertial measurement
MEMS
Motion tracking

description: The need for position and orientation information in a wide variety of applications has led to the development of equally varied methods for providing it. Amongst the alternatives, inertial navigation is a solution that o ffers self-contained operation and provides angular rate, orientation, acceleration, velocity, and position information. Until recently, the size, cost, and weight of inertial sensors has limited their use to vehicles with relatively large payload capacities and instrumentation budgets. However, the development of  microelectromechanical system (MEMS) inertial sensors now o ers the possibility of using inertial measurement in smaller, even human-scale, applications.  Though much progress has been made toward this goal, there are still many obstacles. While operating independently from any outside reference, inertial measurement su ers from unbounded errors that grow at rates up to cubic in time. Since the reduced size and cost of these new miniaturized sensors comes at the expense of accuracy and stability, the problem of error accumulation becomes more acute. Nevertheless, researchers have demonstrated that useful results can be obtained in real-world applications.  The research presented herein provides several contributions to the development of human-scale inertial navigation. A calibration technique allowing complex sensor models to be identified using inexpensive hardware and linear solution techniques has been developed. This is shown to provide significant improvements in the accuracy of the calibrated outputs from MEMS inertial sensors. Error correction algorithms based on easily identifiable characteristics of the sensor outputs have also been developed. These are demonstrated in both one- and three-dimensional navigation. The results show significant improvements in the levels of accuracy that can be obtained using these inexpensive sensors. The algorithms also eliminate empirical, application-specific simplifications and heuristics, upon which many existing techniques have depended, and make inertial navigation a more viable solution for tracking the motion around us.
Register und Stichwortbüchlein zu den Protokollen der Sitzungen des Verwaltungsrats
Creators: name: Hero
Publisher: name: [s.n.]
Year: 1898

description: Enthält: Register von 1898 bis 1917 (Gustav Maier gewidmet, der 20 Jahre lang das Protokoll führte); 2 Stichwortbüchlein zu den Protokollen 1964-1970 und 1971-1975
description: Deutsch
Unterlagen zu den Protokollen der Sitzungen des Verwaltungsrats III
Creators: name: Hero
Publisher: name: [s.n.]
Year: 1966

description: Enthält: Bericht über Option auf Lido/Verona, Organisation Geschäftsleitung, Orientierung über Geschäftsgang etc.
description: Darin: Verzeichnis
description: Deutsch
Der  offizielle Empfang der B.I.Z. Delegierten durch die Stadt Basel
Creators: name: Teichmann, Albert
Publisher: name: [s.n.]
Year: 1935
Subjects: Porträtfotografie

description: Gruppenporträt der Delegierten der Bank für Internationalen Zahlungsausgleich beim Basler Emfang. Abgelichtet sind unter anderem Dr. A. Sarasin (Verwaltungsratspräsident der Schweizerischen Nationalbank), Bundesrat Motta, Generaldirektor Pierre Quesnay, Sir Charles Addis, Gouverneur Morcau (Banque de France), Regierungsrat Miescher (Finanzdirektor Basel)
description: Titel und Name der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Aufnahme
description: Datierung gemäss Abdruck der Fotografie in der Basler Nationalzeitung vom 23. April 1930
[Porträt des Benedikt Meyer-Kraus mit seiner Frau Marie]
Creators: name: Höflinger, Jakob
Publisher: name: [s.n.]
Year: 1880
Subjects: Porträtfotografie

description: J. Höflinger
description: Abzug auf eine Kabinettkarte montiert
description: Name der abgelichteten Personen auf der Rückseite der Kabinettkarte handschriftlich notiert
Gender trait differences and nurse caring
Creators: name: Laurella, Vanessa Brown
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Nursing Theories

description: This research explored if nurses' identified gender trait influences their level of caring towards patients. The basic assumptions guiding this study were that (a) caring in nursing is associated with traditional socially constructed feminine roles; and (b) gender trait identity designates the degree to which people describe themselves as being feminine or masculine. A descriptive exploratory design examined the following research question: Does the gender trait orientation of nurses influence the quality of the caring component of nursing care? Study participants were 700 randomly selected registered nurses (RNs) from the state of Utah. A survey was mailed consisting of two instruments and a demographic questionnaire. The response rate was 40% for a sample of 279 RNs. The Caring Behavior Inventory (CBI) was utilized to measure dimensions of nurse caring. This instrument had never been tested with a nurse-only sample. Therefore, factor analyses were performed to establish validity of the tool. Both instruments used in this study (CBI and Bem Sex Role Inventory (BSRI)) demonstrated reliability and validity in the nurse sample. One-way analyses of variance (ANOVAs) were performed on the data to answer the research question. Significance (p
[Gruppenporträt von Basler Theologen]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1875
Subjects: Porträtfotografie
Burckhardt, Abel1841-1883
Riggenbach, Christoph Johannes1818-1890
Respinger, Johann Rudolf1808-1878
Bernoulli-Riggenbach, Eduard1819-1899
Lotz, Christoph1800-1891
Sarasin, Adolf1802-1885

description: Gruppenbild von Basler Theologen. Hintere Reihe von links von rechts: Eduard Bernolli Riggenbach, Adolf Christ-Sarasin, Christoph Lotz, Adolf Sarasin. Vordere Reihe von links nach rechts: Abel Burckhardt, Johann Christoph Riggenbach, Johann Rudolf Respinger
description: Unbekannte/r Fotograf/in
description: Namen der abgelichteten Personen gemäss handschriftlichen Notiz auf der Unterlage
description: Abzug auf eine Unterlage montiert
Oberst Paravicini mit Tochter Frau Hoffmann-Paravicini
Creators: name: Taeschler-Signer, Carl
Publisher: name: [s.n.]
Year: 1880
Subjects: Porträtfotografie
Hoffmann-Paravicini, Adèle1859-1924

description: Porträt des Rudolf Paravicini mit seiner Tochter Adèle Hoffmann-Paravicini
description: Taeschler-Signer
description: Abzug auf eine Kabinettkarte aufgezogen
description: Datierung und Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Aria Duetto à 6 (in Discante) : del'Opperette du Magnyfique : "Ma Cher Enfant, dès le bas Age"
Creators: name: Grétry, André-Ernest-Modeste
name: Sedaine, Michel-Jean
Publisher: name: [s.n.]
Year: 1773

description: Stimmen: 2 Soprane + Bassinstrument + unvollst. Violine I auf 3 Systemen (duo, Secondar le Vocce) ; 2 Soprane (due Soprani [Clementine + Aldobrandin]) ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (alto viola) ; Bassinstrument (basso)
description: Del Signore Gretry ; [Text von Michel-Jean Sedaine]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire März 2021 HAN-Katalogisierungsregeln jpl
Aria Duetto à 8 (in Discante) : del'Opperette de l'Amy de la Maison : "Tout ce qu'il vous plaira"
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1771

description: Stimmen: Sopran + Tenor + Bassinstrument + unvollst. Violine I auf 3 Systemen (duo) ; Sopran (Agathe) ; Tenor (Celicour) ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (viola/alto viola) ; Bassinstrument (basso) ; Oboe I (oboe primo) ; Oboe II (oboe secondo)
description: Del Signore Gretry ; [Text von Jean-François Marmontel]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
Aria Duetto à 5 (in Discante) : del'opperette du Magnifique : "Je ne sais pourquoy je pleure"
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1773

description: Stimmen: Melodie/Direktionsstimme (2 Soprane ohne Text + unvollst. Violine I auf 1 System) (pour la voix) ; 2 Soprane (Clementine + Alix) + Bassinstrument (duo) ; Violine I (violino primo) ; Violine II (violino secondo) ; Bassinstrument (basso)
description: Del Signore Gretry ; [Text von Jean-François Marmontel]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
Aria Duetto à 8 in Discante : del'opperette du Huron : "Ne vous rebutés pas, voila que je vous aime!"
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1768

description: Stimmen: Melodie/Direktionsstimme (2 Soprane ohne Text + unvollst. Violine I auf 1 System) (violino & la vocce, picolo partitione) ; 2 Soprane (Gilotin + St. Yves) (due soprani) ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (alto viola) ; Bassinstrument (basso) ; Kontrabass (contra basso) ; Oboe I (oboe primo) ; Oboe II (oboe secondo) ; Umschlag
description: Del Signore Gretry ; [Text von Jean-François Marmontel]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
Seidenband: Kapital, Kunst & Krise : Didaktisches Dossier : Unterrichtsmaterialien und Handreichungen zur Ausstellung (Mittel- und Oberstufe)
Creators: name: [s.n.]
Publisher: name: Musehum.BL
Year: 2003
Subjects: Textilindustrie
Seidenband
Seidenindustrie
Seide
Wirtschaft

description: "Seidenband" ist eine Ausstellung des Musehum.BL zur Industriegeschichte der Region
Aria Terzetto à 8 in 2 Discante & Basso ove Baridone del'Opperette Silvain : "Vennés, vennés, c'est icy que l'on s'aime" ["Venez, venez vivre avec nous, c'est ici que l'on s'aime"]
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1770

description: Stimmen: 2 Soprane und Bass ohne Text + unvollst. Violine I auf 3 Systemen (picolo partitione) (2 Ex.) ; 2 Soprane (Pauline + Lucette) + Bassinstrument (due Soprani) ; Bass (Dolmon Pere) (2 Ex.) ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (alto viola) ; Bassinstrument (basso) ; Flöte (flauto solo) ; Umschlag
description: Del Signore Gretry ; [Text von Jean-François Marmontel]
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
Aria Duetto à 6 (in Discante) : Del'Opperette du Tableau Parlant : "Je brulerai d'une ardeur eternelle"
Creators: name: Grétry, André-Ernest-Modeste
name: Marmontel, Jean François
Publisher: name: [s.n.]
Year: 1769

description: Stimmen: Sopran (Colombine) + Tenor (Pierrot) + unvollst. Bassinstrument (basso) ; Violine I (violino primo) ; Violine II (violino secondo) ; Viola (viola) ; Bassinstrument (basso) (2 Ex.)
description: Del Signore Gretry ; [Text von Jean-François Marmontel]
description: Mehrere Stimmen mit Notiz: "No. 19 à Mademoiselle Merian"
description: Französisch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire September 2020 HAN-Katalogisierungsregeln
Analysis of extended pedigrees for localizing of genes in neuropyschiatric disorders
Creators: name: Knight, Stacey
Publisher: name: University of Utah
Year: 2012
Subjects: Autism
Genetic association
Genetic epidemiology
Linkage analysis
Shared genomic segments
Tourette Syndrome

description: The purpose of this dissertation is to evaluate, modify, and develop bioinformatic tools that can be applied to extended pedigrees for the localization of genes involved in complex diseases, specifically focusing on Tourette Syndrome (TS) and Autism Spectrum Disorder (ASD). Three analytically techniques are examined - linkage, association, and shared genomic segments (SGS). With respect to linkage, MCMC methods were applied to a large TS pedigree to conduct a parametric linkage analysis. This was the first time that a linkage analysis was performed on the full pedigree in its entirety. We found linkage peaks for a qualitative analysis of TS on chromosome 3p and for a quantitative analysis of tic severity on chromosome 1p (LOD = 3.1 and 3.3, respectively). With respect to association, we developed a new weighting algorithm to perform association analyses in pedigrees. The algorithm considers all relationships simultaneously in arbitrary-structured pedigrees and assigns weights to pedigree members that can be used in subsequent association analyses to address relatedness. This new method outperformed a previous weighting approach. However, limitations were  also evident. Further examination of the validity and power of this weighting approach, in addition to other association analyses, variance correction (VC) and a naïve (ignore relatedness), was performed.
Dynamic tunneling force microscopy and single electron tunneling force spectroscopy
Creators: name: Johnson, Jon Paul
Publisher: name: University of Utah
Year: 2012
Subjects: Dielectric
Dynamic tunneling force microscopy
Electronic trap states
Scanned probe microscopy
Single electron
Tunneling

description: An introduction to Scanning Probe Microscopy is given along with some basic principles in the detection of electron tunneling by Atomic Force Microscopy (AFM)  using electrostatic force. Dynamic Tunneling Force Microscopy (DTFM), a new scanned probe force-detected tunneling technique, is presented and described, in which shuttling of electrons between electron trap states and a conductive AFM probe provides a means to image these trap states with subnanometer spatial resolution. The further development of Single Electron Tunneling Force Spectroscopy (SETFS) is described, providing a method to measure the energy of electronic trap states. It is used to find the energy spectrum of individual monolayer-protected gold clusters. A novel technique is presented whereby the electron trap states' depth and energy are independently determined using SETFS. Finally, a new technique is described and explored, by which "single spin" electron spin resonance measurements can in principle be performed. The method employs the detection of magnetic resonance through spin dependent tunneling, providing a means to identify individual paramagnetic electron states in dielectric films with atomic spatial resolution.