cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hinge
Creators: name: Baldino, Noah
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Creative writing (incl. scriptwriting)

description: A typical door has three parts: the pin, the knuckles, and the leaves. The two leaves touch the surface: one for the door, one for the frame. The knuckle's where the leaves meet in the middle. It lets the door move once the pin's slid in, to hold the thing in place. The leaves are also known as wings. When a door is closed, the wings touch, pressed perfectly together: door to hinge to frame. The knuckles are hidden on the inside, then. From the outside, you might think the door is floating. To open the door, you first need a body. The identical wings will part. The door will retreat to clear a space. Then, through the frame, our bodies might move.
Benefits of a European project on diagnostics of highly pathogenic agents and assessment of potential “dual use” issues
Creators: name: Grunow, Roland
name: Ippolito, G.
name: Jacob, Daniela
name: Sauer, Ursula
name: Rohleder, Anna
name: Caro, A. Di
name: Iacovino, R.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2014
Subjects: subject: EQAE in diagnostic
subject: anthrax
subject: tularemia
subject: plague
subject: melioidosis
subject: glanders
subject: brucellosis
subject: dual use research of concern
subject: 610 Medizin

description: Quality assurance exercises and networking on the detection of highly infectious pathogens (QUANDHIP) is a joint action initiative set up in 2011 that has successfully unified the primary objectives of the European Network on Highly Pathogenic Bacteria (ENHPB) and of P4-laboratories (ENP4-Lab) both of which aimed to improve the efficiency, effectiveness, and response capabilities of laboratories directed at protecting the health of European citizens against high consequence bacteria and viruses of significant public health concern. Both networks have established a common collaborative consortium of 37 nationally and internationally recognized institutions with laboratory facilities from 22 European countries. The specific objectives and achievements include the initiation and establishment of a recognized and acceptable quality assurance scheme, including practical external quality assurance exercises, comprising living agents, that aims to improve laboratory performance, accuracy, and detection capabilities in support of patient management and public health responses; recognized training schemes for diagnostics and handling of highly pathogenic agents; international repositories comprising highly pathogenic bacteria and viruses for the development of standardized reference material; a standardized and transparent Biosafety and Biosecurity strategy protecting healthcare personnel and the community in dealing with high consequence pathogens; the design and organization of response capabilities dealing with cross-border events with highly infectious pathogens including the consideration of diagnostic capabilities of individual European laboratories. The project tackled several sensitive issues regarding Biosafety, Biosecurity and “dual use” concerns. The article will give an overview of the project outcomes and discuss the assessment of potential “dual use” issues.
sj-xlsx-1-ajl-10.1177_15598276211028557 – Supplemental Material for Knowledge, Attitude, and Practice of Orthopedic Manual Physical Therapists Toward Lifestyle Screening and Education: A Descriptive Study
Creators: name: Zollinger, Jillian M.
name: Katuli, Sozina D.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental Material, sj-xlsx-1-ajl-10.1177_15598276211028557 for Knowledge, Attitude, and Practice of Orthopedic Manual Physical Therapists Toward Lifestyle Screening and Education: A Descriptive Study by Jillian M. Zollinger and Sozina D. Katuli in American Journal of Lifestyle Medicine
Supplemental Material, sj-pdf-2-pch-10.1177_21501351211007102 - “No Official Help Is Available”—Experience of Parents and Children With Congenital Heart Disease During COVID-19
Creators: name: Marino, L. V.
name: Wagland, R.
name: Culliford, D. J.
name: Bharucha, T.
name: Sodergren, S. C.
name: Darlington, Anne-Sophie E.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 111403 Paediatrics
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental Material, sj-pdf-2-pch-10.1177_21501351211007102 for “No Official Help Is Available”—Experience of Parents and Children With Congenital Heart Disease During COVID-19 by L. V. Marino, R. Wagland, D. J. Culliford, T. Bharucha, S. C. Sodergren and Anne-Sophie E. Darlington in World Journal for Pediatric and Congenital Heart Surgery
Investigating critical success factors (CSF's) in enterprise risk management (ERM) adoption in the telecommunication industry: case of Algeria telecommunication industry.
Creators: name: Bouraba, Mohamed Amine
Publisher: name: Zenodo
Year: 2025
Subjects: Enterprise Risk Management (ERM)
Critical Success Factors (CSFs)
Telecommunication Industry
Risk Management
Multi-Sim Card Enablement
Market Penetration
Regulatory Authority for Post and Telecommunications

description: This research investigates the Critical Success Factors (CSFs) influencing the adoption ofEnterprise Risk Management (ERM) in the Telecommunication Industry of Algeria, with a focuson the dynamic and complex risk environment faced by the sector. The study employs qualitativemethods in an exploratory design, incorporating interviews with twenty-six key informants fromAlgeria's Telecommunication industry to discern the factors prompting ERM adoption. Findingsreveal that ERM adoption remains at an early stage, with organizations predominantly employingtraditional "silo" risk management methods. The research contributes by developing a customizedERM framework tailored to the specific challenges of the Algerian telecommunications industry,emphasizing the need for enhanced risk education and awareness among stakeholders. Theproposed framework aims to foster collaboration, information sharing, and effective riskmanagement practices to address both existing and emerging risks in the sector.The research asserts that the Algerian telecommunication industry is maturing and facesvulnerability to diverse risks, necessitating the implementation of a robust ERM framework. Theproposed framework, designed to accommodate strategic organizational objectives and manageemotional risks, emerges as a crucial tool in navigating the dynamic risk landscape.Recommendations include further research on Algeria's telecommunication industry and exploringthe role of ERM frameworks in driving organizational performance.
sj-docx-1-jop-10.1177_02698811211032440 – Supplemental material for GABAergic modulation of performance in response inhibition and interference control tasks
Creators: name: Faßbender, Kaja
name: Bey, Katharina
name: Lippold, Julia V
name: Aslan, Behrem
name: Hurlemann, René
name: Ettinger, Ulrich
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-1-jop-10.1177_02698811211032440 for GABAergic modulation of performance in response inhibition and interference control tasks by Kaja Faßbender, Katharina Bey, Julia V Lippold, Behrem Aslan, René Hurlemann and Ulrich Ettinger in Journal of Psychopharmacology
MSProGene: integrative proteogenomics beyond six-frames and single nucleotide polymorphisms
Creators: name: Zickmann, Franziska
name: Renard, Bernhard Y.
Publisher: name: Robert Koch-Institut
Year: 2015
Subjects: subject: Animals
subject: Algorithms
subject: Mass Spectrometry
subject: Software
subject: Databases Genetic
subject: Peptides/chemistry
subject: Proteins/genetics
subject: Gene Expression Profiling
subject: Polymorphism Single Nucleotide
subject: Sequence Analysis RNA
subject: Proteomics/methods
subject: Bartonella/genetics
subject: Filarioidea/genetics
subject: Genomics/methods
subject: Proteins/chemistry
subject: Proteins/metabolism
subject: 610 Medizin

description: Ongoing advances in high-throughput technologies have facilitated accurate proteomic measurements and provide a wealth of information on genomic and transcript level. In proteogenomics, this multi-omics data is combined to analyze unannotated organisms and to allow more accurate sample-specific predictions. Existing analysis methods still mainly depend on six-frame translations or reference protein databases that are extended by transcriptomic information or known single nucleotide polymorphisms (SNPs). However, six-frames introduce an artificial sixfold increase of the target database and SNP integration requires a suitable database summarizing results from previous experiments. We overcome these limitations by introducing MSProGene, a new method for integrative proteogenomic analysis based on customized RNA-Seq driven transcript databases. MSProGene is independent from existing reference databases or annotated SNPs and avoids large six-frame translated databases by constructing sample-specific transcripts. In addition, it creates a network combining RNA-Seq and peptide information that is optimized by a maximum-flow algorithm. It thereby also allows resolving the ambiguity of shared peptides for protein inference. We applied MSProGene on three datasets and show that it facilitates a database-independent reliable yet accurate prediction on gene and protein level and additionally identifies novel genes.
In Situ TEM Mechanical Testing of Irradiated Oxide Dispersion Strengthened Alloys
Creators: name: Yano, Kayla Haruko
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Metals and alloy materials
Nuclear engineering (incl. fuel enrichment and waste processing and storage)
Materials engineering not elsewhere classified

description: The objective of this dissertation is to demonstrate the use of in situ TEM mechanical testing to find mechanical properties of as received, self-ion, and proton irradiated Fe-9%Cr ODS. The desire to work at small scale in the characterization of irradiated materials to reduce costs and improve throughput, require the development of novel methods to assess mechanical properties in volume-limited irradiation damage layers. Yet at these micrometer or nanometer scales, the mechanical properties can begin to be impacted by size effects. In this work micropillar compression, cantilever bending, lamellae indentation, and clamped beam fracture testing is conducted on ion-irradiated Fe-9%Cr ODS to find yield stress, elastic modulus, flow stress, and fracture toughness. Micropillars in compression allow us to define a minimum sample dimension, which approaches the obstacle spacing of the material, at which size effects are observed. This relationship between sample dimension and obstacle spacing defined through micropillar compression is extended to a new testing geometry, cantilever bending, and material property, flow stress. Lessons learned during the cantilever bending informed the clamped beam design for conducting fracture testing on a ductile engineering alloy at micrometer scales. Finally, lamellae indentation was conducted to link qualitative observations of the microstructure under load with literature strength of obstacle values. By combining an understanding of the microstructure of irradiated Fe-9%Cr ODS and the in situ TEM technique, one can find the bulk-like mechanical properties of ion irradiated Fe-9%Cr ODS.
Additional file 3 of Empowerment interventions designed for persons living with chronic disease - a systematic review and meta-analysis of the components and efficacy of format on patient-reported outcomes
Creators: name: Stepanian, Natalie
name: Larsen, Marie Hamilton
name: Mendelsohn, Joshua B.
name: Mariussen, Kari L.
name: Heggdal, Kristin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 3: Supplementary file 3. Graph Summary plot ROB2.
How Active Are Porcine Endogenous Retroviruses (PERVs)?
Creators: name: Denner, Joachim
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2016
Subjects: subject: porcine endogenous retroviruses
subject: human endogenous retroviruses
subject: xenotransplantation
subject: retroviruses
subject: 610 Medizin

description: Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called xenotransplantation. In contrast to human endogenous retroviruses (HERVs), which are mostly defective and not replication-competent, PERVs are released from normal pig cells and are infectious. PERV-A and PERV-B are polytropic viruses infecting cells of several species, among them humans; whereas PERV-C is an ecotropic virus infecting only pig cells. Virus infection was shown in co-culture experiments, but also in vivo, in the pig, leading to de novo integration of proviruses in certain organs. This was shown by measurement of the copy number per cell, finding different numbers in different organs. In addition, recombinations between PERV-A and PERV-C were observed and the recombinant PERV-A/C were found to be integrated in cells of different organs, but not in the germ line of the animals. Here, the evidence for such in vivo activities of PERVs, including expression as mRNA, protein and virus particles, de novo infection and recombination, will be summarised. These activities make screening of pigs for provirus number and PERV expression level difficult, especially when only blood or ear biopsies are available for analysis. Highly sensitive methods to measure the copy number and the expression level will be required when selecting pigs with low copy number and low expression of PERV as well as when inactivating PERVs using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated nuclease (CRISPR/Cas) technology.
Factors influencing childhood obesity – the establishment of a population-wide monitoring system in Germany
Creators: name: Varnaccia, Gianni
name: Zeiher, Johannes
name: Lange, Cornelia
name: Jordan, Susanne
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: HEALTH MONITORING
subject: OBESITY
subject: INDICATORS
subject: CHILDREN
subject: PREVENTION
subject: 610 Medizin

description: Obesity poses a danger to childhood health and can continue to have a negative impact on health into adulthood. Currently, about 15% of children and adolescents in Germany are overweight or obese. Moreover, significant data on the multifactorial causes of childhood obesity that is systematically recorded, regularly updated and obtainable at the nationwide level are not yet available in Germany. As such, the Robert Koch Institute is establishing a population-wide system to monitor the factors that are relevant to childhood obesity (AdiMon). AdiMon will be available by the end of 2017. This paper outlines the methodological approach that is being used to establish AdiMon and describes the current results of the project (the development of an initial set of core indicators). The project began by undertaking a systematic literature review aimed at piecing together the latest knowledge on factors that influence childhood obesity. The factors that were identified were then sorted according to relevance, and appropriate indicators were selected. This was followed up by research into data sources that – as far as possible – provide significant data that are regularly collected but that also provide for regional differentiation. Work is currently underway to analyse these indicators and data sources. Once this work has been completed, the indicator set will be finalised and the results published on the internet. Population-wide monitoring of factors relevant to childhood obesity takes the following types of indicators into account: behavioural factors (such as physical activity), biological factors (such as genetic predisposition), prenatal and early-childhood factors (such as breastfeeding), psychosocial factors (such as parents’ health consciousness), environmental factors (such as playgrounds in the local area), contextual factors (such as a migrant background) and prevention measures as well as measures to promote health (such as expenditure by statutory health insurers). The population-wide monitoring uses the following data sources: epidemiological studies, social sciences surveys, official statistics and geo-information systems, as well as routine, economic and media data. This paper demonstrates that population-wide monitoring can provide significant information about the distribution and causes of obesity in childhood, and thus enable the need for action to be recognised at an early stage, initial approaches for preventive measures to be identified and developments to be tracked over time.
2023 International Seminar on BioData and AI (ISBA) White Book
Creators: name: Xiaofeng, Wei
name: P. Crawley, Francis
name: Lijin, You
name: Cong, Hua
name: Ekmekci, Perihan Elif
name: Chen, Chen
name: CAO, Jianfeng
name: Scaplehorn, Niki
name: Bharathy, Gnana
name: Yadav, Gitanjali
name: Bednarczyk, Dominik
name: Li, Zhicheng
name: Hu, Lianglin
name: Zhu, Christopher
name: Zhang, Lili
name: Li, Jianhui
name: HE, NEKO
Publisher: name: 2023 ISBA Organization Committee
Year: 2024

description: 2023 International Seminar on BioData and AI (ISBA) White Book is a non-published report compiled by the ISBA organizing committee to organize and summarize the content of the seminar. The White Book covers multiple fields such as “artificial intelligence,” “data ethics,” “biological data technology,” and “open science and sharing.” We aim to promote the development of relevant disciplines and technologies through these contents and provide a platform for global researchers to communicate and collaborate.

Please note that the document is available in both Chinese and English versions, and you can switch between them in the files list.

If you have any question, please mail to CNGB_ISBA@cngb.org
THE STRUCTURE OF THE CELL NUCLEUS AND CANCER CHEMORESISTANCE
Creators: name: afyani, Farzaneh Atrian
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Oncology and carcinogenesis not elsewhere classified

description: Cancers have the ability to develop resistance to traditional therapies. The important role of the tumor microenvironment in transforming nonaggressive tumor cells into an aggressive and chemoresistant cancer has been abundantly addressed. Mechanical cues from the tumor environment, such as matrix stiffness and geometry, transfer to the cell nucleus via the cytoskeleton and change nuclear morphology (e. g, chromatin organization, size and shape). Such alterations are known to accompany or follow the acquisition of chemoresistance. Nuclear matrix proteins such as the Nuclear Mitotic Apparatus (NuMA) are highly involved in higher order chromatin organization and contribute to sustain the physical structure of the cell nucleus, but it isyet to be determined how such structural proteins respond to microenvironmental changes. We have shown previously that tumors cultured in curved geometry (similar to the ductal architecture of breast tissue) display significantly different drug sensitivities compared to those cultured on a flat surface, and that a major morphological difference between these two culture conditions is nuclear shape (i.e., circularity). Our hypothesis is that mechanical cues from the tumor microenvironment alter nuclear features that control the phenotypic response of cancer cells to antiproliferative drugs. Morphological analysis of the cell nucleus in the curved conformation as well as hydrogel and hanging drop systems (with amorphous geometry) showed that only nodules in the curved set-up have nuclear morphometry (shape and size) similar to that of breast tumors of the corresponding subtypes in vivo. In addition, we compared the sensitivity of triple negative breast tumors to cisplatin, with proven efficacy in the clinics, and SAHA, an epigenetic drug that so far failed in breast cancer treatment. Our results suggest higher sensitivity to cisplatin and lower sensitivity to SAHA of breast cancer cells cultured in duct-like geometry compared to the amorphous systems. To evaluate the importance of nuclear morphometry in drug response we altered nuclear size and shape using latrunculin. Under this condition, the number of apoptotic and growth-arrested cells increased following treatments with cisplatin and SAHA, respectively.
Hepatitis E virus infection in Europe: surveillance and descriptive epidemiology of confirmed cases, 2005 to 2015
Creators: name: Aspinall, E. J.
name: Couturier, E.
name: Faber, Mirko
name: Said, B.
name: Ijaz, S.
name: Tavoschi, L.
name: Takkinen, J.
name: Adlhoch, Cornelia
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: Hepatitis E virus (HEV) is an under-recognised cause of acute hepatitis in high-income countries. The purpose of this study was to provide an overview of testing, diagnosis, surveillance activities, and data on confirmed cases in the European Union/European Economic Area (EU/EEA). A semi-structured survey was developed and sent to 31 EU/EEA countries in February 2016, 30 responded. Twenty of these countries reported that they have specific surveillance systems for HEV infection. Applied specific case definition for HEV infection varied widely across countries. The number of reported cases has increased from 514 cases per year in 2005 to 5,617 in 2015, with most infections being locally acquired. This increase could not be explained by additional countries implementing surveillance for HEV infections over time. Hospitalisations increased from less than 100 in 2005 to more than 1,100 in 2015 and 28 fatal cases were reported over the study period. EU/EEA countries are at different stages in their surveillance, testing schemes and policy response to the emergence of HEV infection in humans. The available data demonstrated a Europe-wide increase in cases. Standardised case definitions and testing policies would allow a better understanding of the epidemiology of HEV as an emerging cause of liver-related morbidity.
sj-docx-1-hss-10.1177_15563316211027828 – Supplemental material for Less Invasive Pediatric Spinal Deformity Surgery: The Case for Robotic-Assisted Placement of Pedicle Screws
Creators: name: Morse, Kyle W.
name: Otremski, Hila
name: Page, Kira
name: Widmann, Roger F.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-hss-10.1177_15563316211027828 for Less Invasive Pediatric Spinal Deformity Surgery: The Case for Robotic-Assisted Placement of Pedicle Screws by Kyle W. Morse, Hila Otremski, Kira Page and Roger F. Widmann in HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
Legionnaires’ disease in Europe, 2011 to 2015
Creators: name: Beauté, Julien
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: 610 Medizin

description: Under the coordination of the European Centre for Disease Prevention and Control (ECDC), the European Legionnaires’ disease Surveillance Network (ELDSNet) conducts surveillance of Legionnaires’ disease (LD) in Europe. Between 2011 and 2015, 29 countries reported 30,532 LD cases to ECDC (28,188 (92.3%) confirmed and 2,344 (7.7%) probable). Four countries (France, Germany, Italy and Spain) accounted for 70.3% of all reported cases, although their combined populations represented only 49.9% of the study population. The age-standardised rate of all cases increased from 0.97 cases/100,000 population in 2011 to 1.30 cases/100,000 population in 2015, corresponding to an annual average increase of 0.09 cases/100,000 population (95%CI 0.02–0.14; p = 0.02). Demographics and infection setting remained unchanged with ca 70% of cases being community-acquired and 80% occurring in people aged 50 years and older. Clinical outcome was known for 23,164 cases, of whom 2,161 (9.3%) died. The overall case fatality ratio decreased steadily from 10.5% in 2011 to 8.1% in 2015, probably reflecting improved reporting completeness. Five countries (Austria, Czech Republic, Germany, Italy, and Norway) had increasing age-standardised LD notification rates over the 2011−15 period, but there was no increase in notification rates in countries where the 2011 rate was below 0.5/100,000 population.
"Philosopher d'une manière 'mariale': Alentour du verset: Petite phénoménologie des Mystères de Marie-Aimée Manchon"
Creators: name: Lewis, Stephen E.
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Phenomenology
subject: Catholic Church
subject: Spiritual formation

description: A review article focused on phenomenological method and Christian thought in Marie-Aimée Manchon's book _Alentour du verses: Petite phénoménologie des Mystère_ (Ad Solem, 2019).
Integrating Pest and Pollinator Management: Assessing the Impact of Commercial Watermelon Production on Pests and Pollinators
Creators: name: Ternest, John Jay
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Agriculture, land and farm management not elsewhere classified
Agro-ecosystem function and prediction
Farm management, rural management and agribusiness
Agricultural systems analysis and modelling
Sustainable agricultural development

description: Fruit set in cucurbit crops such as watermelon is entirely dependent upon pollinators, which makes them an important aspect of grower management. This reliance on pollinators means that growers must consider them when making pest management decisions, especially when using pesticides, which can have a negative impact on pollinators. Thus, pest management in watermelon production faces a potential trade-off between pests and pollinators. The ways in which growers manage this trade-off could have a large impact on the communities of both groups and the yield of the crop.
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration
Creators: name: Rhee, Soo-Yon
name: Varghese, Vici
name: Holmes, Susan P.
name: Zyl, Gert U. Van
name: Steegen, Kim
name: Boyd, Mark A.
name: Cooper, David A.
name: Nsanzimana, Sabin
name: Saravanan, Shanmugam
name: Charpentier, Charlotte
name: Oliveira, Tulio De
name: Etiebet, Mary-Ann A.
name: Garcia, Federico
name: Goedhals, Dominique
name: Gomes, Perpetua
name: Günthard, Huldrych F.
name: Hamers, Raph L.
name: Hoffmann, Christopher J.
name: Hunt, Gillian
name: Jiamsakul, Awachana
name: Kaleebu, Pontiano
name: Kanki, Phyllis
name: Kantor, Rami
name: Kantor, Rami
name: Kerschberger, Bernhard
name: Schmidt, Daniel
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: Drug resistance
subject: HIV-1
subject: Antiretroviral therapy
subject: Reverse transcriptase
subject: Tenofovir
subject: WHO-recommended first-line
subject: 610 Medizin

description: Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen. However, the full spectrum of reverse transcriptase (RT) mutations selected in individuals with VF on such a regimen is not known. To identify TDF regimen-associated mutations (TRAMs), we compared the proportion of each RT mutation in 2873 individuals with VF on a WHO-recommended first-line TDF-containing regimen to its proportion in a cohort of 50,803 antiretroviral-naïve individuals. To identify TRAMs specifically associated with TDF-selection pressure, we compared the proportion of each TRAM to its proportion in a cohort of 5805 individuals with VF on a first-line thymidine analog-containing regimen. We identified 83 TRAMs including 33 NRTI-associated, 40 NNRTI-associated, and 10 uncommon mutations of uncertain provenance. Of the 33 NRTI-associated TRAMs, 12 – A62V, K65R/N, S68G/N/D, K70E/Q/T, L74I, V75L, and Y115F – were more common among individuals receiving a first-line TDF-containing compared to a first-line thymidine analog-containing regimen. These 12 TDF-selected TRAMs will be important for monitoring TDF-associated transmitted drug-resistance and for determining the extent of reduced TDF susceptibility in individuals with VF on a TDF-containing regimen.
Projekt zur Schließung von Impflücken bei Schülern der 6. Klassenstufe und Lehrern im Landkreis Görlitz (Sachsen)
Creators: name: Schultz, Undine
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: 610 Medizin

description: Seit dem Jahr 2013 werden im Landkreis Görlitz bei Kindern der 6. Klassenstufe die Impfpässe jährlich kontrolliert.1,2,3 Im Jahr 2016 erfolgte dies vom 23. Mai 2016 – 27. Mai 2016 am Gesundheitsamt (GA) des Landkreises (LK) Görlitz. Dabei wurden 36 Schulen mit 1.949 Sechstklässlern und 1.318 Lehrern kontrolliert. Von diesen haben 785 (40 %) Schüler und 65 (5 %) Lehrer ihre Impfpässe abgegeben. Da die Beteiligung der Lehrer von 26 % im Jahr 2013 auf 5 % im Jahr 2016 zurückgegangen ist, werden Lehrer ab 2017 nicht mehr in die Auswertung einbezogen. Insgesamt waren 68 % der Untersuchten ausreichend gegen Keuchhusten geschützt, davon 57 % mit altersgerechtem vollständigem Impfschutz und bei 11 % der Schüler waren die empfohlenen fünf Jahre zwischen 5. und 6. Keuchhusten-Impfung noch nicht abgelaufen. Gegen Masern waren insgesamt 93 % immun – bei 91 % lag ein altersgerechter vollständiger Impfschutz vor und 2 % galten als immun, da sie vor 1959 geboren wurden. Es wurden 276 Rücklaufbögen ausgeteilt mit der Anmerkung „unvollständiger nicht altersgerechter Impfschutz“ für Pertussis. Von diesen trafen 42 (15 %) wieder im GA Görlitz ein und bei 39 Personen (14 %) wurde die empfohlene Pertussis-Impfung bzw. die Titerbestimmung (s. Diskussion, S. 255 ff) durchgeführt. Leider impften Ärzte bei drei (1 %) Personen trotz unvollständigem Impfschutz nicht. Bei den Masern-Impfungen wurden 57 Rücklaufbögen ausgeteilt mit der Anmerkung „unvollständiger nicht altersgerechter Impfschutz“. Von diesen trafen acht (14 %) wieder im GA Görlitz ein. Es wurde bei sieben (12 %) Personen die fehlende Masern- Impfung durchgeführt. Bei einem Schüler erfolgte eine Nachtragung im Impfpass.
Defining Airport Operational Sustainability for the U.S. General Aviation Airports
Creators: name: Gu, Yue
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Air transportation and freight services

description: While the general public may be familiar with commercial airports, there are thousands of small General Aviation (GA) airports serving communities across the United States. Many of these airports are under pressure to survive and to bring in more revenue without impinging on the community and environment. Many organizations and governmental agencies such as the Federal Aviation Administration (FAA), now recognize the value of sustainable development and importance of operation to airport sustainability. Achieving operational sustainability is a means that may help airports on sustainable development and has positive impacts on airports’ economic viability, natural resource conservation, and social responsibility. However, airport operational sustainability is rarely defined in a consistent, measurable manner (Johnson & Gu, 2017).
This study explored the understanding of airport operational sustainability among five GA Regional and Local airports. Based on the findings, a new definition of airport operational sustainability for U.S Regional and Local GA airports was proposed. A set of performance metrics for airport operational sustainability was developed. The outcomes of the study may help airport shareholders contribute to airport sustainability planning through a better understanding of sustainability principles. A set of performance metrics for airport operational sustainability may be used to quantify the sustainability achievements of airports and help airports measure their performance.
AXBOROTLI JARAYONLAR BO'LIMINI O'QITISH METODIKASI
Creators: name: Qobilova, Gulchiroy
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: "Axborotli jarayonlar bo‘limini o‘qitish metodikasi" mavzusida taqdim etilgan maqola axborotli jarayonlarning o‘qitish metodikasi va bu jarayonlarni samarali ta'limga tatbiq etish usullarini o‘rganadi. Ushbu maqolada axborotli jarayonlarning nazariy asoslari va amaliyotdagi qo‘llanilishi, shuningdek, bu jarayonlarni o‘qitish metodlari va sun’iy intellekt yordamida optimallashtirishning samaralari ko‘rib chiqiladi. Axborotli jarayonlarni o‘qitishda interfaol metodlardan foydalanishning ahamiyati, o‘qitish jarayonini modernizatsiya qilish va talabalar uchun o‘rganishni qiziqarli va samarali qilish haqida so‘z boradi. Dasturiy ta'minot, shifrlash, uzatish va axborot xavfsizligini ta'minlash kabi mavzularni sun’iy intellekt bilan simulyatsiya qilish metodlari orqali o‘rganishning ta'lim jarayoniga qo‘shgan hissasi taqdim etiladi. Maqolada axborotli jarayonlarni o‘qitishda yangi, zamonaviy metodlarni joriy etish orqali o‘quvchilarning axborot texnologiyalariga bo‘lgan qiziqishini oshirish hamda ularning professional malakasini rivojlantirish uchun imkoniyat yaratish ko‘rib chiqiladi.
Análise Dos Padrões De Quebra Em Espinhos De Peixes: Cerrito Psg02-Valverde Pelotas/Rs
Creators: name: Ulguim, Victória F.
name: Ulguim, Priscilla F.
Publisher: name: Zenodo
Year: 2017
Subjects: Zonação
Zonation
Ichtyoarchaeology
Ictiofauna
Cerritos
Zoorarchaeology
Zooarqueologia

description: O presente trabalho tem por escopo propor um sistema de zonação para espinhos de peixe. A implementação desse sistema visa registrar a presença e a frequência de distintas quebras observadas durante as análises da arqueofauna do sítio PSG02. Ademais, a aplicação deste método tem por objetivo diferenciar os distintos padrões de quebra e o grau de fragmentação dos elementos, buscando assim compreender melhor os processos tafonômicos naturais e culturais envolvidos.
Additional file 1 of Empowerment interventions designed for persons living with chronic disease - a systematic review and meta-analysis of the components and efficacy of format on patient-reported outcomes
Creators: name: Stepanian, Natalie
name: Larsen, Marie Hamilton
name: Mendelsohn, Joshua B.
name: Mariussen, Kari L.
name: Heggdal, Kristin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary file 1. Literature Search Strategies from Ovid Medline, Embase, Cinahl, APA PsycInfo, Cochrane Central and Web of Science.
sj-pdf-3-aph-10.1177_10105395211031689 – Supplemental material for Behavioral Responses in Korean Non-COVID-19 Patients With Neurological Disorders During the COVID-19 Outbreak
Creators: name: Oh, Juyeon
name: Chung, Eun Joo
name: Seo, Jung Hwa
name: Kang, Mi-Ri
name: Lee, Sukyoon
name: Park, Jin-Sung
name: Oh, Seong-il
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-3-aph-10.1177_10105395211031689 for Behavioral Responses in Korean Non-COVID-19 Patients With Neurological Disorders During the COVID-19 Outbreak by Juyeon Oh, Eun Joo Chung, Jung Hwa Seo, Mi-Ri Kang, Sukyoon Lee, Jin-Sung Park and Seong-il Oh in Asia Pacific Journal of Public Health
Comparative Genomic Analysis of Globally Dominant ST131 Clone with Other Epidemiologically Successful Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages
Creators: name: Shaik, Sabiha
name: Ranjan, Amit
name: Tiwari, Sumeet K.
name: Hussain, Arif
name: Nandanwar, Nishant
name: Kumar, Narender
name: Jadhav, Savita
name: Semmler, Torsten
name: Baddam, Ramani
name: Islam, Mohammed Aminul
name: Alam, Munirul
name: Wieler, Lothar H.
name: Watanabe, Haruo
name: Ahmed, Niyaz
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: Escherichia coli
subject: genomics
subject: bacterial evolution
subject: ST131 lineage
subject: molecular epidemiology
subject: 610 Medizin

description: Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and extended-spectrum-β-lactamase (ESBL)-producing E. coli clones, such as ST38, ST405, and ST648 have been studied widely, no comparative genomic data with respect to other genotypes exist for ST131. In this study, comparative genomic analysis was performed for 99 ST131 E. coli strains with 40 genomes from three other STs, including ST38 (n = 12), ST405 (n = 10), and ST648 (n = 18), and functional studies were performed on five in-house strains corresponding to the four STs. Phylogenomic analysis results from this study corroborated with the sequence type-specific clonality. Results from the genome-wide resistance profiling confirmed that all strains were inherently multidrug resistant. ST131 genomes showed unique virulence profiles, and analysis of mobile genetic elements and their associated methyltransferases (MTases) has revealed that several of them were missing from the majority of the non-ST131 strains. Despite the fact that non-ST131 strains lacked few essential genes belonging to the serum resistome, the in-house strains representing all four STs demonstrated similar resistance levels to serum antibactericidal activity. Core genome analysis data revealed that non-ST131 strains usually lacked several ST131-defined genomic coordinates, and a significant number of genes were missing from the core of the ST131 genomes. Data from this study reinforce adaptive diversification of E. coli strains belonging to the ST131 lineage and provide new insights into the molecular mechanisms underlying clonal diversification of the ST131 lineage.
Durrell’s Delta and Dylan Thomas’ ‘Prologue to an Adventure’
Creators: name: Gifford, James
Publisher: name: Humanities Commons
Year: 2004
Subjects: subject: Literature, Modern
subject: Welsh literature
subject: British literature

description: In 1939, Keidrych Rhys charged that Dylan Thomas' "Prologue to an Adventure" was reprinted "in Delta (Paris) without acknowledgement... without permission"; however, Ralph Maud contrarily argues "Durrell, as editor of Delta, asked Thomas for contributions and published something by him in all three issues" (123). Thomas' letters support the latter position and suggest he returned to the story for Delta, aiming for publication in a book project through the Obelisk Press in Paris. Hence, this later printing indicates his final intentions. This challenges the authoritative editions of Thomas, works, and I argue for a corrected edition of "Prologue to an Adventure" based on the Delta printing.
Additional file 2 of Empowerment interventions designed for persons living with chronic disease - a systematic review and meta-analysis of the components and efficacy of format on patient-reported outcomes
Creators: name: Stepanian, Natalie
name: Larsen, Marie Hamilton
name: Mendelsohn, Joshua B.
name: Mariussen, Kari L.
name: Heggdal, Kristin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 2: Supplementary file 2. Table 5. Risk of Bias (ROB) assessments and short reasons for the selected assessments.
title: Fact Sheet: Infopaket für Apotheken - Arzneimittel und Umwelt
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2025
Subjects: subject: Humanarzneimittel
subject: Chemikalien

description: Die Apotheke ist ein naheliegender Ort für Gespräche über Arzneimittel und deren Wirkung auf Mensch und Umwelt sowie über die Entsorgung von Altmedikamenten. Dieses Infopaket für Apotheken bietet dem Apothekenpersonal vertiefte Hintergrundinformationen für solche Gespräche. Es werden Anregungen gegeben, wie Apothekerinnen*Apotheker zu einer umweltgerechten Anwendung und Entsorgung von Medikamenten beitragen können. Darüber hinaus werden vom Umweltbundesamt zur Verfügung gestellten Informationsmaterialien und ihr zielgruppengerechter Verwendungszweck erläutert.
Additional file 1 of How useful do communities find the health and wellness centres? A qualitative assessment of India’s new policy for primary health care
Creators: name: Abhishek, Shriyuta
name: Garg, Samir
name: Keshri, Vikash Ranjan
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
ISLAMOPHOBIA AND ‘OTHERING’: NARRATIVES OF INTERNATIONAL HIJABI MUSLIM WOMEN IN HIGHER EDUCATION
Creators: name: Karimi, Nastaran
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Other education not elsewhere classified

description: Historically, various minority groups have faced multiple forms of prejudice and discrimination. The sources of such attitudes are mainly ignorance about these groups. One such group is Muslims living in western countries. The fear and dread of Muslims and Islam has deep historical roots; however, these attitudes escalated after the September 11 tragedy. After September 11, Muslims became the headlines of news and Americans were exposed to distorted images of Muslims in the media. This misrepresentation of Muslims in the media led to yet another form of xenophobia, which resulted in ‘othering’ Muslims. In schools and universities, the story was not different. In the following study, I discuss the ‘othering’ of 6 international hijabi Muslim women studying at a Midwestern University in light of the Islamophobic tendencies developed after September 11. I create narratives of these experiences to understand how hijabi Muslim women make sense of their experiences in relation to the larger sociopolitical discourse. These narratives contribute to the larger effort of creating an equitable educational experience for students from all backgrounds.
I.M.E. Theory – Transformation of Information into Matter through Observation
Creators: name: Tsikriteas, Anastasios
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Information Theory
subject: mass-energy equivalence
subject: quantum physics
subject: Landauer principle
subject: observation
subject: entropy
subject: consciousness
subject: Consciousness
subject: physics of information

description: The I.M.E. (Information–Mass–Energy) Theory proposes that unobserved information holds latent energy which, through the act of observation, can be transformed into measurable energy and ultimately into matter. 

Rooted in Landauer’s Principle, quantum superposition, and mass-energy equivalence (E=mc²), the theory mathematically models a new dynamic where observation acts as the bridge between abstract information and physical reality. 

This work introduces a set of equations that link entropy with energetic potential and matter formation. It offers a novel interpretation of observation not as passive measurement, but as a physically generative transformation.

If experimentally validated, I.M.E. Theory may revolutionize our understanding of existence, consciousness, and energy generation from information.Developed by Anastasios Tsikriteas, with analytical structuring support from AI Synergos (OpenAI).
Additional file 2 of How useful do communities find the health and wellness centres? A qualitative assessment of India’s new policy for primary health care
Creators: name: Abhishek, Shriyuta
name: Garg, Samir
name: Keshri, Vikash Ranjan
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 2
sj-pdf-1-ijb-10.1177_13670069211031001 – Supplemental material for Second language experience influences salience of phonological units in spoken word production in the first language
Creators: name: Wang, Jie
name: Wong, Andus Wing-Kuen
name: Chen, Hsuan-Chih
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: Language Studies not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-ijb-10.1177_13670069211031001 for Second language experience influences salience of phonological units in spoken word production in the first language by Jie Wang, Andus Wing-Kuen Wong and Hsuan-Chih Chen in International Journal of Bilingualism
Predictors of Sexual Quality of Life Among Postoperative Coronary Artery Bypass Graft Patients
Creators: name: Arthit Oeychanai
name: Napaporn Wanitkun
name: Thitipong Tankumpuan
name: Teerapong Tocharoenchok
Publisher: name: Zenodo
Year: 2025
Subjects: Metabolic Syndrome, Sexual Knowledge, Sexual Communication, Sexual Response, Function Capacity, Sexual Quality of Life.

description: Abstract

Background: After 6-8 weeks of coronary artery bypass grafting surgery, patients can have sexual activity. However, patients do not get information from health officers such as how to have safe sex as much as it should before returning home. Aim: The study aimed to examine the predictors of sexual quality of life including metabolic syndrome, sexual knowledge, sexual communication, sexual response and function capacity in postoperative coronary artery bypass graft patients. Method: This descriptive cross-sectional study was conducted with 132 post-coronary artery bypass grafting patients at least 3 months without cognitive impairment. The random selection was applied from one university hospital. The data were collected with questionnaires consisting of demographic data, metabolic syndrome, sexual knowledge, sexual communication, sexual response, function capacity, and sexual quality of life. The data were analyzed using hierarchical multiple regression statistics with stepwise method. Results: The findings indicated that the sexual quality of life score was 44.94 ± 21.85. Regression analysis showed that estimated glomerular filtration rate (eGFR), sexual knowledge and sexual response were statistically significant to predict the sexual quality of life at 19%. The variable of best prediction was sexual response (β = .342, p < .001) Conclusion: The study showed that patients did not have sufficient information about sexual quality after coronary artery bypass grafting surgery. Therefore, the patients had sexual problems including decreasing in sexual knowledge and sexual response after having surgery.