cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Proton-conducting membranes from polyphenylenes containing Armstrong’s acid
Creators: name: Künzel-Tenner, Andy
name: Kirsch, Christoph
name: Dolynchuk, Oleksandr
name: Rößner, Leonard
name: Wach, Maxime
name: Kempe, Fabian
name: Unwerth, Thomas
name: Lederer, Albena
name: Sebastiani, Daniel
name: Armbrüster, Marc
name: Sommer, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 540

description: This study demonstrates the use of 1,5-naphthalenedisulfonic acid as a suitable building block for the efficient and economic preparation of alternating sulfonated polyphenylenes with high ion-exchange capacity (IEC) via Suzuki polycondensation. Key to large molar masses is the use of an all-meta-terphenyl comonomer instead of m-phenyl, the latter giving low molar masses and brittle materials. A protection/deprotection strategy for base-stable neopentyl sulfonates is successfully implemented to improve the solubility and molar mass of the polymers. Solution-based deprotection of polyphenylene neopentyl sulfonates at 150 °C in dimethylacetamide eliminates isopentylene quantitatively, resulting in membranes with high IEC (2.93 mequiv/g) and high proton conductivity (σ = 138 mS/cm). Water solubility of these copolymers with high IEC requires thermal cross-linking to prevent their dissolution under operating conditions. By balancing the temperature and time of the cross-linking process, water uptake can be restricted to 50 wt %, retaining an IEC of 2.33 mequiv/g and a conductivity of 85 mS/cm. Chemical stability is addressed by treatment of the membranes under Fenton’s conditions and by considering barrier heights for desulfonation using density functional theory (DFT) calculations. The DFT results suggest that 1,5-disulfonated naphthalenes are at least as stable as sulfonated polyphenylenes against desulfonation.
Lending cyclicality in dual banking countries: The influence of bank ownership
Creators: name: Anwar, Urooj
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 350204
subject: Financial institutions (incl. banking)

description: This study examines ownership’s influence on banks’ lending cyclicality over the business cycles in dual banking countries. It investigates the lending cyclicality of banks in dual-banking economies by using a panel data set of 606 banks, including both Islamic and conventional banks, from 2001-2019 in 17 dual-banking countries. Applying the System Generalised Method of Moments (GMM) estimator, when a distinction was made between conventional and Islamic banks’ financing behaviour, Islamic banks display countercyclical lending behaviour. In examining the influence of public and private ownership on the lending cyclicality of banks, overall public banks were found to be countercyclical. The findings of this study offer important insights for researchers, policymakers, and stakeholders in the global financial industry.
Healthcare utilization and costs among women diagnosed with uterine fibroids: a longitudinal evaluation for 5 years pre- and post-diagnosis
Creators: name: Fuldeore, Mahesh
name: Hongbo Yang
name: Soliman, Ahmed M
name: Winkel, Craig
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: To evaluate the healthcare utilization, treatments, and costs incurred by women with uterine fibroids (UF), compared to those without UF, for 5 years before and 5 years after diagnosis. This is a longitudinal, retrospective case–control study. A total of 84,954 women with a diagnosis of UF, along with matched controls of women without UF, were selected from the Truven Health MarketScan claims database (2000–2010). The date of diagnosis of the UF patient was assigned as the index date for both the UF patient and her matched control. Healthcare resource utilization, treatments, and costs (in 2010 USD) were evaluated annually for the 5 year periods before and after the index date. UF patients had more outpatient and emergency room visits than controls before diagnosis, and more inpatient, outpatient, and emergency room visits than controls after diagnosis. Annual total healthcare costs were significantly higher for patients than controls during the last 3 years pre-index and all 5 years post-index. Overall, the difference was $12,623 over 10 years, with a difference of $1435 in the 5 years pre-diagnosis and a difference of $11,188 in the 5 years post-diagnosis. The cost difference between UF patients and controls was highest in the first year post-diagnosis, reaching $6131, and the difference was even larger when comparing clinically symptomatic UF patients to controls. The use of medications and surgical procedures related to UF peaked in the year post-diagnosis, with 39% of patients receiving a surgical treatment within the year. UF patients included in the study did not include undiagnosed and potentially asymptomatic UF patients; the impact of disease severity on the costs of UF patients was not evaluated. Patients with UF incurred significantly higher healthcare utilization and costs than those without UF, both pre- and post-diagnosis.
Levels of F2-isoprostanes, F4-neuroprostanes, and total nitrate/nitrite in plasma and cerebrospinal fluid of patients with traumatic brain injury
Creators: name: H.-C. Yen
name: T.-W. Chen
name: T.-C. Yang
name: H.-J. Wei
name: J.-C. Hsu
name: C.-L. Lin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Several events occurring during the secondary damage of traumatic brain injury (TBI) can cause oxidative stress. F2-isoprostanes (F2-IsoPs) and F4-neuroprostanes (F4-NPs) are specific lipid peroxidation markers generated from arachidonic acid and docosahexaenoic acid, respectively. In this study, we evaluated oxidative stress in patients with moderate and severe TBI. Since sedatives are routinely used to treat TBI patients and propofol has been considered an antioxidant, TBI patients were randomly treated with propofol or midazolam for 72 h postoperation. We postoperatively collected cerebrospinal fluid (CSF) and plasma from 15 TBI patients for 6–10 d and a single specimen of CSF or plasma from 11 controls. Compared with the controls, the TBI patients exhibited elevated levels of F2-IsoPs and F4-NPs in CSF throughout the postsurgery period regardless of the sedative used. Compared with the group of patients who received midazolam, those who received propofol exhibited markedly augmented levels of plasma F2-IsoPs, which were associated with higher F4-NPs levels and lower total nitrate/nitrite levels in CSF early in the postsurgery period. Furthermore, the higher CSF F2-IsoPs levels correlated with 6-month and 12-month worse outcomes, which were graded according to the Glasgow Outcome Scale. The results demonstrate enhanced oxidative damage in the brain of TBI patients and the association of higher CSF levels of F2-IsoPs with a poor outcome. Moreover, propofol treatment might promote lipid peroxidation in the circulation, despite possibly suppressing nitric oxide or peroxynitrite levels in CSF, because of the increased loading of the lipid components from the propofol infusion.
RP-HPLC analysis of seco-iridoid glycoside swertiamarin from different Swertia species
Creators: name: Parthraj R. Kshirsagar
name: Pai, Sandeep R.
name: Mansingraj S. Nimbalkar
name: Gaikwad, Nikhil B.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Genus Swertia is valued for its great medicinal potential; mainly Swertia chirayita (Roxb. ex Fleming) H. Karst. is used in traditional medicine for a wide range of diseases. Seco-iridoid glycosides like swertiamarin is referred with enormous pharmacological potentials. The aim of the study was to identify a suitable substitute to S. chirayita by quantifying seco-iridoid swertiamarin from five different Swertia species endemic to the Western Ghats. The reverse-phase high-performance liquid chromatography diode array detector analyses were performed and chromatographic separation was achieved on a Lichrospher 100, C18e (5 µm) column (250–4.6 mm). A mobile phase consisting of acetonitrile and water (25:75) was used for separation. Results indicated that the concentration of the marker compound has been found to vary largely between and within the species from different localities. The content of swertiamarin was the highest in S. chirayita compared to the other species studied herein, advocating the use of Swertia minor as an alternate source to S. chirayita.
RP-HPLC analysis of seco-iridoid glycoside swertiamarin from different Swertia species
Creators: name: Parthraj R. Kshirsagar
name: Pai, Sandeep R.
name: Mansingraj S. Nimbalkar
name: Gaikwad, Nikhil B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Genus Swertia is valued for its great medicinal potential; mainly Swertia chirayita (Roxb. ex Fleming) H. Karst. is used in traditional medicine for a wide range of diseases. Seco-iridoid glycosides like swertiamarin is referred with enormous pharmacological potentials. The aim of the study was to identify a suitable substitute to S. chirayita by quantifying seco-iridoid swertiamarin from five different Swertia species endemic to the Western Ghats. The reverse-phase high-performance liquid chromatography diode array detector analyses were performed and chromatographic separation was achieved on a Lichrospher 100, C18e (5 µm) column (250–4.6 mm). A mobile phase consisting of acetonitrile and water (25:75) was used for separation. Results indicated that the concentration of the marker compound has been found to vary largely between and within the species from different localities. The content of swertiamarin was the highest in S. chirayita compared to the other species studied herein, advocating the use of Swertia minor as an alternate source to S. chirayita.
Automatically Composing High-Performance and Cost-effective AI Systems with MLCommons' Collective Mind and MLPerf
Creators: name: Fursin, Grigori
name: Suresh, Arjun
Publisher: name: Zenodo
Year: 2024
Subjects: collective mind
MLPerf
MLCommons
automation
reusability
modularity
composability
efficiency
machine learning
artificial intelligence

description: Invited presentation at the MLPerf-Bench workshop at HPCA'24 about a new collaborative project to help everyone automatically compose high-performance and cost-efficient AI Systems from the most suitable models, software and hardware from any vendor with the help of MLCommons' Collective Mind and MLPerf benchmarks:

github.com/mlcommons/ck

access.cKnowledge.org

Collective Mind (CM) is a collection of portable, extensible, technology-agnostic and ready-to-use automation recipes with a human-friendly interface (aka CM scripts) to unify and automate all the manual steps required to compose, run, benchmark and optimize complex ML/AI applications on any platform with any software and hardware: see online catalog and source code.

CM scripts require Python 3.7+ with minimal dependencies and are continuously extended by the community and MLCommons members to run natively on Ubuntu, MacOS, Windows, RHEL, Debian, Amazon Linux and any other operating system, in a cloud or inside automatically generated containers while keeping backward compatibility.

CM scripts were originally developed based on the following requirements from the MLCommons members to help them automatically compose and optimize complex MLPerf benchmarks, applications and systems across diverse and continuously changing models, data sets, software and hardware from Nvidia, Intel, AMD, Google, Qualcomm, Amazon and other vendors:

must work out of the box with the default options and without the need to edit some paths, environment variables and configuration files

must be non-intrusive, easy to debug and must reuse existing user scripts and automation tools (such as cmake, make, ML workflows, python poetry and containers) rather than substituting them; 

must have a very simple and human-friendly command line with a Python API and minimal dependencies;

must require minimal or zero learning curve by using plain Python, native scripts, environment variables and simple JSON/YAML descriptions instead of inventing new workflow languages

must have the same interface to run all automations natively, in a cloud or inside containers.

Check CM getting started guide and don't hesitate to get in touch via our public Discord server.
A cross-sectional survey on wounds in horses in New Zealand
Creators: name: CL Theoret
name: CF Bolwell
name: CB Riley
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: AIM: To determine the frequency and type of skin wounds encountered by New Zealand veterinarians in their equine patients, the duration and estimated costs of treatment as well as the expected outcomes for these wounds. METHODS: An online survey was sent to all veterinarians registered with the New Zealand Equine Veterinary Association. The survey comprised questions on the location and experience of respondents, the number of wound-related cases in relation to the total equine caseload, the type and anatomical location of wounds treated, the frequency, duration and costs of treatments, the outcome of wound treatment and an estimate of the most common causes of death or euthanasia in their equine patients. RESULTS: The survey response rate was 110/262 (41.9%). The median number of equine cases seen by respondents was 20 (interquartile range (IQR) 6–60) per month; of these, five (IQR 2–10) were wound related. Wounds ranked third after lameness and respiratory disease for the relative frequency with which respondents encountered them. Of 102 respondents 59 (58%) reported that their clients frequently treated wounds incurred by their horse without consulting a veterinarian. Wounds on the distal limb, whether involving only the skin or also deeper structures, were reported by 86/101 (85%) respondents as the most frequently encountered. Wounds in this location also incurred the longest treatment period and were the most prone to develop complications. Finally, wounds ranked second, after colic, as the most common cause of death/euthanasia in the veterinary respondents’ equine patients. CONCLUSIONS: The data obtained via the survey indicate that skin wounds, particularly on the distal limb, are a common occurrence in horses in New Zealand and, when they involve structures underlying the skin, are costly and time-consuming to manage and may lead to decreased performance, retirement or euthanasia. Consequently, we recommend that more effort be devoted to the education of equine veterinarians and owners, and that appropriate research funds be allocated to help improve patient outcomes.
Mapping traces in the art of Ibrahim Mahama
Creators: name: Attewell, Chrisél
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Disappearance is an inherent quality of the ‘trace’. A trace, moving within the ambiguous space between absence and presence, refers to some other event connected with it. In this essay, I apply my hybrid model of the trace, derived from the philosophies of Jacques Derrida, Charles Sanders Peirce, and Tim Ingold, in an analysis of the works of Ghanaian artist, Ibrahim Mahama. Mahama’s art responds to traces of failure and disappearance in the urban landscapes of Ghana. Working with materials and spaces in decay, Mahama maps residues of the past embedded in the material, tracing within its narratives of trade, migration, labour, capital, and commodity exploitation. By engaging communities around him in collaborative processes that are often large of scale and presented in public spaces, Mahama recollects memories of labour and exposes extreme histories that inform the present.
A cross-sectional survey on wounds in horses in New Zealand
Creators: name: CL Theoret
name: CF Bolwell
name: CB Riley
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: AIM: To determine the frequency and type of skin wounds encountered by New Zealand veterinarians in their equine patients, the duration and estimated costs of treatment as well as the expected outcomes for these wounds. METHODS: An online survey was sent to all veterinarians registered with the New Zealand Equine Veterinary Association. The survey comprised questions on the location and experience of respondents, the number of wound-related cases in relation to the total equine caseload, the type and anatomical location of wounds treated, the frequency, duration and costs of treatments, the outcome of wound treatment and an estimate of the most common causes of death or euthanasia in their equine patients. RESULTS: The survey response rate was 110/262 (41.9%). The median number of equine cases seen by respondents was 20 (interquartile range (IQR) 6–60) per month; of these, five (IQR 2–10) were wound related. Wounds ranked third after lameness and respiratory disease for the relative frequency with which respondents encountered them. Of 102 respondents 59 (58%) reported that their clients frequently treated wounds incurred by their horse without consulting a veterinarian. Wounds on the distal limb, whether involving only the skin or also deeper structures, were reported by 86/101 (85%) respondents as the most frequently encountered. Wounds in this location also incurred the longest treatment period and were the most prone to develop complications. Finally, wounds ranked second, after colic, as the most common cause of death/euthanasia in the veterinary respondents’ equine patients. CONCLUSIONS: The data obtained via the survey indicate that skin wounds, particularly on the distal limb, are a common occurrence in horses in New Zealand and, when they involve structures underlying the skin, are costly and time-consuming to manage and may lead to decreased performance, retirement or euthanasia. Consequently, we recommend that more effort be devoted to the education of equine veterinarians and owners, and that appropriate research funds be allocated to help improve patient outcomes.
Healthcare utilization and costs among women diagnosed with uterine fibroids: a longitudinal evaluation for 5 years pre- and post-diagnosis
Creators: name: Fuldeore, Mahesh
name: Hongbo Yang
name: Soliman, Ahmed M
name: Winkel, Craig
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cell Biology
subject: Medicine

description: Objective:To evaluate the healthcare utilization, treatments, and costs incurred by women with uterine fibroids (UF), compared to those without UF, for 5 years before and 5 years after diagnosis.Research design and methods:This is a longitudinal, retrospective case–control study. A total of 84,954 women with a diagnosis of UF, along with matched controls of women without UF, were selected from the Truven Health MarketScan claims database (2000–2010). The date of diagnosis of the UF patient was assigned as the index date for both the UF patient and her matched control.Main outcome measures:Healthcare resource utilization, treatments, and costs (in 2010 USD) were evaluated annually for the 5 year periods before and after the index date.Results:UF patients had more outpatient and emergency room visits than controls before diagnosis, and more inpatient, outpatient, and emergency room visits than controls after diagnosis. Annual total healthcare costs were significantly higher for patients than controls during the last 3 years pre-index and all 5 years post-index. Overall, the difference was $12,623 over 10 years, with a difference of $1435 in the 5 years pre-diagnosis and a difference of $11,188 in the 5 years post-diagnosis. The cost difference between UF patients and controls was highest in the first year post-diagnosis, reaching $6131, and the difference was even larger when comparing clinically symptomatic UF patients to controls. The use of medications and surgical procedures related to UF peaked in the year post-diagnosis, with 39% of patients receiving a surgical treatment within the year.Key limitations:UF patients included in the study did not include undiagnosed and potentially asymptomatic UF patients; the impact of disease severity on the costs of UF patients was not evaluated.Conclusions:Patients with UF incurred significantly higher healthcare utilization and costs than those without UF, both pre- and post-diagnosis.
A cross-sectional survey on wounds in horses in New Zealand
Creators: name: CL Theoret
name: CF Bolwell
name: CB Riley
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Physiology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine

description: AIMTo determine the frequency and type of skin wounds encountered by New Zealand veterinarians in their equine patients, the duration and estimated costs of treatment as well as the expected outcomes for these wounds.METHODSAn online survey was sent to all veterinarians registered with the New Zealand Equine Veterinary Association. The survey comprised questions on the location and experience of respondents, the number of wound-related cases in relation to the total equine caseload, the type and anatomical location of wounds treated, the frequency, duration and costs of treatments, the outcome of wound treatment and an estimate of the most common causes of death or euthanasia in their equine patients.RESULTSThe survey response rate was 110/262 (41.9%). The median number of equine cases seen by respondents was 20 (interquartile range (IQR) 6–60) per month; of these, five (IQR 2–10) were wound related. Wounds ranked third after lameness and respiratory disease for the relative frequency with which respondents encountered them. Of 102 respondents 59 (58%) reported that their clients frequently treated wounds incurred by their horse without consulting a veterinarian. Wounds on the distal limb, whether involving only the skin or also deeper structures, were reported by 86/101 (85%) respondents as the most frequently encountered. Wounds in this location also incurred the longest treatment period and were the most prone to develop complications. Finally, wounds ranked second, after colic, as the most common cause of death/euthanasia in the veterinary respondents’ equine patients.CONCLUSIONSThe data obtained via the survey indicate that skin wounds, particularly on the distal limb, are a common occurrence in horses in New Zealand and, when they involve structures underlying the skin, are costly and time-consuming to manage and may lead to decreased performance, retirement or euthanasia. Consequently, we recommend that more effort be devoted to the education of equine veterinarians and owners, and that appropriate research funds be allocated to help improve patient outcomes.
Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity
Creators: name: Narasimha Rao Uda
name: Seibert, Volker
name: Stenner-Liewen, Frank
name: Müller, Philipp
name: Herzig, Petra
name: Gabor Gondi
name: Zeidler, Reinhard
name: Dijk, Marc Van
name: Zippelius, Alfred
name: Renner, Christoph
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Hematology
Science Policy
Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Pharmacology
Medicine
Biochemistry

description: Carbonic anhydrase 9 (CA9) and carbonic anhydrase 12 (CA12) were proposed as potential targets for cancer therapy more than 20 years ago. However, to date, there are only very few antibodies that have been described to specifically target CA9 and CA12 and also block the enzymatic activity of their targets. One of the early stage bottlenecks in identifying CA9- and CA12-inhibiting antibodies has been the lack of a high-throughput screening system that would allow for rapid assessment of inhibition of the targeted carbon dioxide hydratase activity of carbonic anhydrases. In this study, we show that measuring the esterase activity of carbonic anhydrase offers a robust and inexpensive screening method for identifying antibody candidates that block both hydratase and esterase activities of carbonic anhydrase’s. To our knowledge, this is the first implementation of a facile surrogate-screening assay to identify potential therapeutic antibodies that block the clinically relevant hydratase activity of carbonic anhydrases.
NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy
Creators: name: Vemika Chandra
name: Bhagyaraj, Ella
name: Ravikanth Nanduri
name: Ahuja, Nancy
name: Gupta, Pawan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: NR1D1 (nuclear receptor subfamily 1, group D, member 1), an adopted orphan nuclear receptor, is widely known to orchestrate the expression of genes involved in various biological processes such as adipogenesis, skeletal muscle differentiation, and lipid and glucose metabolism. Emerging evidence suggests that various members of the nuclear receptor superfamily perform a decisive role in the modulation of autophagy. Recently, NR1D1 has been implicated in augmenting the antimycobacterial properties of macrophages and providing protection against Mycobacterium tuberculosis infection by downregulating the expression of the IL10 gene in human macrophages. This antiinfective property of NR1D1 suggests the need for an improved understanding of its role in other host-associated antimycobacterial pathways. The results presented here demonstrate that in human macrophages either ectopic expression of NR1D1 or treatment with its agonist, GSK4112, enhanced the number of acidic vacuoles as well as the level of MAP1LC3-II, a signature molecule for determination of autophagy progression, in a concentration- and time-dependent manner. Conversely, a decrease in NR1D1 in knockdown cells resulted in the reduced expression of lysosomal-associated membrane protein 1, LAMP1, commensurate with a decrease in the level of transcription factor EB, TFEB. This is indicative of that NR1D1 may have a regulatory role in lysosome biogenesis. NR1D1 being a repressor, its positive regulation on LAMP1 and TFEB is suggestive of an indirect byzantine mechanism of action. Its role in the modulation of autophagy and lysosome biogenesis together with its ability to repress IL10 gene expression supports the theory that NR1D1 has a pivotal antimycobacterial function in human macrophages.
Levels of F2-isoprostanes, F4-neuroprostanes, and total nitrate/nitrite in plasma and cerebrospinal fluid of patients with traumatic brain injury
Creators: name: H.-C. Yen
name: T.-W. Chen
name: T.-C. Yang
name: H.-J. Wei
name: J.-C. Hsu
name: C.-L. Lin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine

description: Several events occurring during the secondary damage of traumatic brain injury (TBI) can cause oxidative stress. F2-isoprostanes (F2-IsoPs) and F4-neuroprostanes (F4-NPs) are specific lipid peroxidation markers generated from arachidonic acid and docosahexaenoic acid, respectively. In this study, we evaluated oxidative stress in patients with moderate and severe TBI. Since sedatives are routinely used to treat TBI patients and propofol has been considered an antioxidant, TBI patients were randomly treated with propofol or midazolam for 72 h postoperation. We postoperatively collected cerebrospinal fluid (CSF) and plasma from 15 TBI patients for 6–10 d and a single specimen of CSF or plasma from 11 controls. Compared with the controls, the TBI patients exhibited elevated levels of F2-IsoPs and F4-NPs in CSF throughout the postsurgery period regardless of the sedative used. Compared with the group of patients who received midazolam, those who received propofol exhibited markedly augmented levels of plasma F2-IsoPs, which were associated with higher F4-NPs levels and lower total nitrate/nitrite levels in CSF early in the postsurgery period. Furthermore, the higher CSF F2-IsoPs levels correlated with 6-month and 12-month worse outcomes, which were graded according to the Glasgow Outcome Scale. The results demonstrate enhanced oxidative damage in the brain of TBI patients and the association of higher CSF levels of F2-IsoPs with a poor outcome. Moreover, propofol treatment might promote lipid peroxidation in the circulation, despite possibly suppressing nitric oxide or peroxynitrite levels in CSF, because of the increased loading of the lipid components from the propofol infusion.
Exploring the role of experimental research photography in architectural design research
Creators: name: Feleke, Tsyon
Publisher: name: Hochschule Anhalt, Dessau
Year: 2024
Subjects: subject: Fotografie
subject: DDC::7** Künste und Unterhaltung::72* Architektur
subject: DDC::7** Künste und Unterhaltung::77* Fotografie, Computerkunst

description: This paper delves into an experimental methodology designed to explore a research question examining the entry of change into social and political discourse. It explores how these experimental methods can be used to excavate and visualise non verbal processes in research particularly architectural design research, which are typically attributed to intuition. Furthermore, the study looks at how these mechanisms can be translated and communicated to a peer group in order to encourage and document alternative meanings made from the experimental project. This approach attempts to demonstrate how this methodology can be applied to architectural design research procedures to understand and enhance how architects come into new knowledge. My primary interest is the application of this method in architectural design research and its usefulness in the intersection between architecture, creativity and practice. The group discussion is centred on a workshop conducted at the Bauhaus Foundation Co-op Master’s Thesis Program in collaboration with fellow workshop participants.
A Practical Style Transfer Pipeline for 3D Animation: Insights from Production R&D
Creators: name: Todo, Hideki
name: Koyama, Yuki
name: Sakai, Kunihiro
name: Komiya, Akihiro
name: Kato, Jun
Publisher: name: arXiv
Year: 2024
Subjects: subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: Our animation studio has developed a practical style transfer pipeline for creating stylized 3D animation, which is suitable for complex real-world production. This paper presents the insights from our development process, where we explored various options to balance quality, artist control, and workload, leading to several key decisions. For example, we chose patch-based texture synthesis over machine learning for better control and to avoid training data issues. We also addressed specifying style exemplars, managing multiple colors within a scene, controlling outlines and shadows, and reducing temporal noise. These insights were used to further refine our pipeline, ultimately enabling us to produce an experimental short film showcasing various styles.
Polarized Cells, Polarized Views: Asymmetric Cell Division in Hematopoietic Cells
Creators: name: Pham, Kim
name: Sacirbegovic, Faruk
name: Russell, Sarah
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 310102
subject: Cell development, proliferation and death
classificationCode: 510302
subject: Classical and physical optics

description: It has long been recognized that alterations in cell shape and polarity play important roles in coordinating lymphocyte functions. In the last decade, a new aspect of lymphocyte polarity has attracted much attention, termed asymmetric cell division (ACD). ACD has previously been shown to dictate or influence many aspects of development in model organisms such as the worm and the fly, and to be disrupted in disease. Recent observations that ACD also occurs in lymphocytes led to exciting speculations that ACD might influence lymphocyte differentiation and function, and leukemia. Dissecting the role that ACD might play in these activities has not been straightforward, and the evidence to date for a functional role in lymphocyte fate determination has been controversial. In this review, we discuss the evidence to date for ACD in lymphocytes, and how it might influence lymphocyte fate. We also discuss current gaps in our knowledge, and suggest approaches to definitively test the physiological role of ACD in lymphocytes.
Criminals by necessity: the risky life of charcoal transporters in Malawi
Creators: name: Smith, Harriet Elizabeth
name: Eigenbrod, Felix
name: Dalitso Kafumbata
name: Hudson, Malcolm D.
name: Schreckenberg, Kate
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences

description: The charcoal industry in sub-Saharan Africa plays a substantial role providing growing urban populations with domestic energy. However, concerns about its environmental impacts have led to punitive policies, resulting in the criminalisation of charcoal-based livelihoods. One factor constraining the development of more effective policy approaches is limited data on the impacts of regulations on the socio-economic outcomes of different value chain actors. We focus on one group of actors: charcoal transporters, who supply charcoal to Zomba, a medium-sized city in Southern Malawi. Drawing on a survey of 201 transporters, we find that they are attracted by fast cash-in-hand, low capital requirements and the lack of alternative local employment opportunities. Both men and women participate, yet transport methods are gendered. Men, who typically transport charcoal on a bicycle, earn three times as much per week as those who carry charcoal on their heads, the main method used by women. However, bicycle users incur higher financial risk due to costs associated with confiscations and damage to bicycles. Unlike in larger cities, an urban elite does not dominate the supply chain in Zomba. We argue that punitive targeting of small-scale charcoal transporters serves only to push them deeper into poverty and does nothing to contribute to sustainable resource management.
NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy
Creators: name: Bhagyaraj, Ella
name: Ravikanth Nanduri
name: Gupta, Pawan
name: Vemika Chandra
name: Ahuja, Nancy
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: NR1D1 (nuclear receptor subfamily 1, group D, member 1), an adopted orphan nuclear receptor, is widely known to orchestrate the expression of genes involved in various biological processes such as adipogenesis, skeletal muscle differentiation, and lipid and glucose metabolism. Emerging evidence suggests that various members of the nuclear receptor superfamily perform a decisive role in the modulation of autophagy. Recently, NR1D1 has been implicated in augmenting the antimycobacterial properties of macrophages and providing protection against Mycobacterium tuberculosis infection by downregulating the expression of the IL10 gene in human macrophages. This antiinfective property of NR1D1 suggests the need for an improved understanding of its role in other host-associated antimycobacterial pathways. The results presented here demonstrate that in human macrophages either ectopic expression of NR1D1 or treatment with its agonist, GSK4112, enhanced the number of acidic vacuoles as well as the level of MAP1LC3-II, a signature molecule for determination of autophagy progression, in a concentration- and time- dependent manner. Conversely, a decrease in NR1D1 in knockdown cells resulted in the reduced expression of lysosomal-associated membrane protein 1, LAMP1, commensurate with a decrease in the level of transcription factor EB, TFEB. This is indicative of that NR1D1 may have a regulatory role in lysosome biogenesis. NR1D1 being a repressor, its positive regulation on LAMP1 and TFEB is suggestive of an indirect byzantine mechanism of action. Its role in the modulation of autophagy and lysosome biogenesis together with its ability to repress IL10 gene expression supports the theory that NR1D1 has a pivotal antimycobacterial function in human macrophages.
Quellen digitalisieren, Digitalisate als Quellen
Creators: name: Wierzoch, Jan
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: Retrodigitalisierung
subject: Forschungsdaten
subject: Geschichtswissenschaft
subject: Gedächtniseinrichtung
subject: 020 Bibliotheks- und Informationswissenschaften

description: Forschungsdaten werden in der Regel als die Daten definiert, die die Grundlage der Forschung bilden, während des Forschungsprozesses entstehen oder dessen Ergebnis sind. In der Geschichtswissenschaft bilden Quellen auf unterschiedlichen Informationsträgern die Forschungsbasis, welche meist in Gedächtniseinrichtungen, also Museen, Bibliotheken oder Archiven, aufbewahrt werden. Im Zuge der digitalen Forschung kommt daher dem Digitalisieren dieser Quellen eine besondere Bedeutung zu, da dieses die Grundlage der digitalen Geschichtswissenschaft bis hin zu den Digital Humanities darstellt und die Quellen weiten Personenkreisen zugänglich gemacht werden können. Diese Arbeit untersucht daher, wie historische Quellen digitalisiert, verwaltet und bereit gestellt werden müssen, um den Anforderungen der Geschichtswissenschaft an ihre Forschungsdaten gerecht zu werden. Dazu wurden zum einen qualitative Interviews mit für die Digitalisierung zuständigen Mitarbeitern aus Gedächtniseinrichtungen geführt, um hier Möglichkeiten und Vorgehensweisen bei Aspekten der Auswahl, Herstellung, Verwaltung und Nutzung der Digitalisate zu beleuchten. Hierbei wurden auch die digitalen Sammlungen der entsprechenden Einrichtungen berücksichtigt. Zum andern fanden qualitative Interviews mit wissenschaftlichen Nutzern statt, um deren Anforderungen an die Digitalisate, ihre Metadaten sowie die Verfügbarkeit und Nachnutzung zu betrachten. Im Ergebnis zeigt sich hierbei, dass sich die Nutzer eine möglichst intuitive, übersichtliche Präsentation der Digitalisate wünschen, die jedoch alle vorhandenen Informationen bei Bedarf bereitstellen kann. Die Daten sollten dabei gut zugänglich und idealerweise verlinkt sein. Eine Beteiligung an organisatorischen Fragen der Digitalisierung oder technische Aspekte stehen nicht im Vordergrund, solange die Zugänglichkeit gegeben ist. Die Anforderungen entsprechen damit den bisherigen, analogen Erwartungen an Gedächtniseinrichtungen, Informationen zu sammeln, zu erschließen, zugänglich zu machen und zu sichern.
Dynamic features of apo and bound HIV-Nef protein reveal the anti-HIV dimerization inhibition mechanism
Creators: name: Suri Moonsamy
name: Soumendranath Bhakat
name: Soliman, Mahmoud E. S.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The first account on the dynamic features of Nef or negative factor, a small myristoylated protein located in the cytoplasm believes to increase HIV-1 viral titer level, is reported herein. Due to its major role in HIV-1 pathogenicity, Nef protein is considered an emerging target in anti-HIV drug design and discovery process. In this study, comparative long-range all-atom molecular dynamics simulations were employed for apo and bound protein to unveil molecular mechanism of HIV-Nef dimerization and inhibition. Results clearly revealed that B9, a newly discovered Nef inhibitor, binds at the dimeric interface of Nef protein and caused significant separation between orthogonally opposed residues, namely Asp108, Leu112 and Gln104. Large differences in magnitudes were observed in the radius of gyration (∼1.5 Å), per-residue fluctuation (∼2 Å), C-alpha deviations (∼2 Å) which confirm a comparatively more flexible nature of apo conformation due to rapid dimeric association. Compared to the bound conformer, a more globally correlated motion in case of apo structure of HIV-Nef confirms the process of dimeric association. This clearly highlights the process of inhibition as a result of ligand binding. The difference in principal component analysis (PCA) scatter plot and per-residue mobility plot across first two normal modes further justifies the same findings. The in-depth dynamic analyses of Nef protein presented in this report would serve crucial in understanding its function and inhibition mechanisms. Information on inhibitor binding mode would also assist in designing of potential inhibitors against this important HIV target.
Evaluation of equilibrium constants for deprotonation and lactonisation of α-D-isosaccharinic acid
Creators: name: Dhanpat Rai
name: Kitamura, Akira
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A great deal of disagreement exists in the literature regarding the intrinsic deprotonation and lactonisation constants of α-D-isosaccharinic acid (ISA). Based on a combination of nuclear magnetic resonance and interpretations using the specific ion interaction theory (SIT) of extensive experimental Ca(ISA)2(cr) solubility data involving α-D-isosaccharinic acid, the reliable value of log10 K° for [HISA(aq) ISA− + H+] is −3.27 ± 0.01 and for [HISA(aq) ISL(α-D-isosaccharinate-1,4-lactone)(aq) + H2O] is 0.49 ± 0.09. These data also provide log10 K° of −3.76 ± 0.09 for the reaction [ISL(aq) + H2O ISA− + H+] and −3.88 ± 0.09 for the composite reaction [HISA(aq) + ISL(aq) ISA− + H+]. Reinterpretation of extensive Ca(ISA)2(cr) solubility data using the SIT activity coefficient model provides log10 K° of −6.40 ± 0.09 for [Ca(ISA)2(cr) Ca2+ + 2(ISA)−] and of 1.70 ± 0.09 for [Ca2+ + ISA− CaISA+] which are consistent with all of the available values.
Arrenoseius Wainstein 1962
Creators: name: BorgesK, Vinicius
name: de MoraesK, Gilberto J.
name: CastilhoK, Raphael de Campos
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Phytoseiidae
Arrenoseius

description: Genus Arrenoseius Wainstein
 Arrenoseius Wainstein, 1962: 12.
 Arrenoseius, Moraes et al. 2004: 55.
description: Published as part of BorgesK, Vinicius, de MoraesK, Gilberto J. & CastilhoK, Raphael de Campos, 2023, A new record of an Arrenoseius Wainstein species and a new species of Chelaseius Muma & Denmark (Mesostigmata: Phytoseiidae) from Brazil, pp. 411-418 in Acarologia 63 (2) on page 412, DOI: 10.24349/soei-hdfd, http://zenodo.org/record/10787132
The spatial and temporal distribution/variation of pesticide residues in Viotikos Kifissos basin before and after the application of a low input crop management system. A three-year study
Creators: name: Charalampous, Angeliki C.
name: Machera, Kyriaki
name: Miliadis, George E.
name: Koupparis, Michael A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Engineering

description: A three-year study of the spatial and temporal variation of pesticide residues in Viotikos Kifissos basin (VKB), in central Greece, before and after the application of Low-Input Crop Management systems (LCM), was carried out between May 2009 and November 2011. A total of 253 water samples from 34 sampling points (boreholes, rivers, wells, vadose zone) were analysed for the presence of more than 200 pesticides and degradation products, using liquid and gas chromatography coupled to tandem mass spectrometry. Samples were prepared by solid-phase extraction (SPE) using Oasis HLB cartridges. Almost 70% of the samples were found positive for the presence of pesticides in amounts greater than the limit of detection. The most frequently detected pesticide was fluometuron, followed by s-metolachlor, metalaxyl-M, imidacloprid and ethalfluralin. The highest concentration was recorded for fluometuron (322 μg L−1), ethalfluralin (123 μg L−1) and s-Metolachlor (36.4 μg L−1). Results showed a reduction of the pesticides detected and quantified in water samples during 2011 compared to those measured in 2009 and 2010.