cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Accumulation and persistence of ivacaftor in airway epithelia with prolonged treatment
Creators: name: Esther, C.R., Jr
name: Guhr Lee, T.N.
name: Gentzsch, M.
name: Cholon, D.M.
name: Quinney, N.L.
Publisher: name: Elsevier B.V.
Year: 2020

description: Background: Current dosing strategies of CFTR modulators are based on serum pharmacokinetics, but drug concentrations in target tissues such as airway epithelia are not known. Previous data suggest that CFTR modulators may accumulate in airway epithelia, and serum pharmacokinetics may not accurately predict effects of chronic treatment. Methods: CF (F508del homozygous) primary human bronchial epithelial (HBE) cells grown at air-liquid interface were treated for 14 days with ivacaftor plus lumacaftor or ivacaftor plus tezacaftor, followed by a 14-day washout period. At various intervals during treatment and washout phases, drug concentrations were measured via mass spectrometry, electrophysiological function was assessed in Ussing chambers, and mature CFTR protein was quantified by Western blotting. Results: During treatment, ivacaftor accumulated in CF-HBEs to a much greater extent than either lumacaftor or tezacaftor and remained persistently elevated even after 14 days of washout. CFTR activity peaked at 7 days of treatment but diminished with further ivacaftor accumulation, though remained above baseline even after washout. Conclusions: Intracellular accrual and persistence of CFTR modulators during and after chronic treatment suggest complex pharmacokinetic and pharmacodynamic properties within airway epithelia that are not predicted by serum pharmacokinetics. Direct measurement of drugs in target tissues may be needed to optimize dosing strategies, and the persistence of CFTR modulators after treatment cessation has implications for personalized medicine approaches.
Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease
Creators: name: Lee, G.
name: Esther, C.R., Jr.
name: McMahon, T.J.
name: Poisson, J.L.
name: Zhu, H.
name: Marek, R.D.
name: Shah, N.
name: Welsby, I.
name: Domowicz, D.A.L.
Publisher: name: Edizioni SIMTI
Year: 2020

description: Background - Red blood cell (RBC) exchange (RCE) transfusion therapy is indicated for certain patients with sickle cell disease (SCD). Although beneficial, this therapy is costly and inconvenient to patients, who may require it monthly or more often. Identification of blood and plasma biomarkers that could improve or help individualise RCE therapy is of interest. Here we examined relevant blood and plasma metabolites and biomarkers of vasoactivity and RBC fragility in a pilot study of SCD patients undergoing RCE using either standard RBC units or RBC units treated with a US Food and Drug Administration (FDA)-approved additive solution containing phosphate, inosine, pyruvate, and adenine ("PIPA"). Materials and methods - In this prospective, single-blind, cross-over pilot clinical trial, patients were randomised to receive either standard RBC exchange or PIPA-treated RBC exchange transfusion with each RCE session over a 6-month treatment period. Pre- and post-transfusion blood samples were obtained and analysed for RBC O2 affinity, ATP, purine metabolites, RBC microparticles, and cell free haemoglobin. Results - Red blood cell O2 affinity was maintained after PIPA-RCE in contrast to standard RCE, after which P50 fell (net O2 affinity rose). Plasma ATP did not change significantly after RCE using either of the RBC unit types. Exchange transfusion with PIPA-treated RBC units led to modest increases in plasma inosine and hypoxanthine. Plasma cell free haemoglobin fell after either standard or PIPA-treated RBC exchange transfusion (novel findings), and to a similar extent. RBC-derived microparticles in the plasma fell significantly and similarly after both standard and PIPA-treated RCE transfusion. Discussion - In summary, treatment of RBCs with PIPA prior to RCE elicited favourable or neutral changes in key metabolic and vascular biomarkers. Further study of its efficacy and safety is recommended and could ultimately serve to improve outcomes in chronically transfused SCD patients.
Nuclear forces and their impact on neutron-rich nuclei and neutron-rich matter
Creators: name: Hebeler, K.
name: Holt, J. D.
name: Menendez, J.
name: Schwenk, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We review the impact of nuclear forces on matter at neutron-rich extremes. Recent results have shown that neutron-rich nuclei become increasingly sensitive to three-nucleon forces, which are at the forefront of theoretical developments based on effective field theories of quantum chromodynamics. This includes the formation of shell structure, the spectroscopy of exotic nuclei, and the location of the neutron dripline. Nuclear forces also constrain the properties of neutron-rich matter, including the neutron skin, the symmetry energy, and the structure of neutron stars. We first review our understanding of three-nucleon forces and show how chiral effective field theory makes unique predictions for many-body forces. Then, we survey results with three-nucleon forces in neutron-rich oxygen and calcium isotopes and neutron-rich matter, which have been explored with a range of many-body methods. Three-nucleon forces therefore provide an exciting link between theoretical, experimental and observational nuclear physics frontiers.
description: 28 pages, 13 figures, 1 table
title: First seizures: Does computed tomography provide the answer?
Creators: name: Burd, Christian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Efficacy studies
subject: MR
subject: CT
subject: Neuroradiology brain
subject: Emergency
subject: Diagnostic procedure
subject: Seizure disorders
subject: Neoplasia
subject: Acute

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Background The lifetime risk of having a seizure is 8-10% 1 and annually around 150,000 people will present with a first seizure in the U.S. 2 A review of 7 studies assessing CT scanning for first seizures found them to be significantly abnormal in...
title: Congenital and acquired disorders of the vertebral bodies
Creators: name: Mestiri, Manel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: Anatomy
subject: Conventional radiography
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Intrauterine diagnosis
subject: Congenital
subject: Developmental disease
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recognize the normal radiological anatomy of vertebral bodies at different stages. Know the normal developmental stages of vertebral bodies during intra uterine life and the cause of observed abnormalities. Detect different types of congenital and...
Elastic properties of the degenerate f.c.c. crystal of polydisperse soft dimers at zero temperature
Creators: name: Narojczyk, J. W.
name: Wojciechowski, K. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Elastic properties of soft, three-dimensional dimers, interacting through site-site n-inverse-power potential, are determined by computer simulations at zero temperature. The degenerate crystal of dimers exhibiting (Gaussian) size distribution of atomic diameters - i.e. size polydispersity - is studied at the molecular number density $1/\sqrt{2}$; the distance between centers of atoms forming dimers is considered as a length unit. It is shown that, at the fixed number density of the dimers, increasing polydispersity causes, typically, an increase of pressure, elastic constants and Poisson's ratio; the latter is positive in most direction. A direction is found, however, in which the size polydispersity causes substantial decrease of Poisson's ratio, down to negative values for large $n$. Thus, the system is partially auxetic for large polydispersity and large n.
description: Conference: International Workshop on Functional and Nanostructured Materials (FNMA)/International Conference on Intermolecular and Magnetic Interactions in Matter (IMIM) Location: L'Aquila, ITALY Date: SEP 27-30,2009
title: ECG-Gated dual Pitch CT Angiography for vessel evaluation prior to Transcatheter Aortic Valve Implant (TAVI).
Creators: name: Macchi, Edoardo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Computer Applications-3D
subject: Angioplasty
subject: CT-Angiography
subject: Vascular
subject: Cardiovascular system
subject: Arteries / Aorta
subject: Haemodynamics / Flow dynamics

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this exhibit is demonstrate the usefulness of ECG-Gated Dual Pitch CT Angiography (DP-CTA) in pre-operative planning for transcatheter aortic valve implantation (TAVI)...
(101805) Edith Frances Cave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Numerical simulations of polarized microwave emission from cosmic particles in the upper atmosphere of the Earth
Creators: name: López-Viejobueno, Jennifer
name: Beitia-Antero, Leire
name: De Castro, Ana Inés Gómez
Publisher: name: Zenodo
Year: 2022

description: Tons of extraterrestrial material plunge into the Earth’s atmosphere over a year [1]. However, lack of information of these particles provided directly from space-based surveys exists. The irregular shape of grains and their immersion in the anisotropic solar radiation and the terrestrial magnetic fields might produce their alignment via radiative torques [2]. Earth observation by the satellite MARTINLARA is proposed. It is a 6-units cubesat that will be located in a circular, dawn- dusk LEO at 500 km over the Earth surface. It will operate at microwave range enabling the detection of the polarization of the dust falling onto the Earth from NEO. Aim: Compute the expected microwave signal and the polarization, as viewed from space, of the aligned grains entering upper Earth atmosphere.
Persistent wheeze in infants: A guide for general pediatricians
Creators: name: Loughlin, C.
name: Ren, C.L.
name: Esther, C.R., Jr.
name: Yu, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Infants with persistent wheeze is a common diagnostic challenge for the general pediatrician because of the broad differential diagnoses. The initial diagnostic approach should include a comprehensive history, physical examination, and chest radiography. Additional testing may be warranted. Involvement of a pediatric pulmonary subspecialist may also be indicated.
title: Endovascular treatment for venous vascular lesions in emergency setting
Creators: name: Macchi, Edoardo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Abdomen
subject: Veins / Vena cava
subject: CT-Angiography
subject: Fluoroscopy
subject: Stents
subject: Venous access
subject: Surgery
subject: Trauma
subject: Haemorrhage
subject: Grafts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Traumatic lesions of the inferior vena cava (IVC) or lesions of other great abdominal veins account for more than 25% of abdominal vascular injuries andthey representchallenging and lethal lesions sustained by trauma patients. Whether caused by...
Use of inhaled imipenem/cilastatin in pediatric patients with cystic fibrosis: A case series
Creators: name: Jones, L.A.
name: McKinzie, C.J.
name: Dellon, E.P.
name: Doucette, L.
name: Esther, C.R.
Publisher: name: Elsevier B.V.
Year: 2019

description: Mycobacterium abscessus is a rapidly-growing, virulent, non-tuberculous mycobacterium that causes progressive inflammatory lung damage and significant decline in lung functionin patients with cystic fibrosis. M. abscessus complex pulmonary infections are notoriously difficult to treat, and while many antibiotics are approved for children, drug allergies or intolerances can prohibit their use. Intravenous imipenem/cilastatin is among the preferred antibiotics for treatment of M. abscessus, however, its use may result in systemic toxicities including hepatic injury and gastrointestinal effects. Case reports document the successful use of inhaled imipenem/cilastatin in adult cystic fibrosis and non- cystic fibrosis patients with non- M. abscessus pulmonary infections. To our knowledge, similar evidence does not exist for pediatric patients. In this case series, we describe two pediatric patients with cystic fibrosis and previous intolerance or lack of response to standard therapies who received inhaled imipenem/cilastatin for the treatment of chronic M. abscessus infection.
Use of telavancin in adolescent patients with cystic fibrosis and prior intolerance to vancomycin: A case series
Creators: name: Bernstein, A.T.
name: McKinzie, C.J.
name: Leigh, M.W.
name: Esther, C.R., Jr
name: Goralski, J.L.
Publisher: name: Elsevier B.V.
Year: 2018

description: The most common pathogen in pediatric cystic fibrosis (CF) patients is Staphylococcus aureus, and drug-resistant species are associated with negative outcomes. Methicillin-resistant Staphylococcus aureus (MRSA) is notoriously hard to treat because many antibiotics are not FDA approved for children and drug allergies or intolerances can prohibit the use of others. Telavancin is currently indicated for hospital-acquired pneumonia and ventilator-associated pneumonia caused by MRSA, but it has not been studied in patients with CF or in pediatrics. As a semi-synthetic derivative of vancomycin, it is unknown if cross-reactivity with telavancin occurs in patients with vancomycin hypersensitivity or intolerance. In this case series, we describe three adolescent patients with CF and previous intolerance to vancomycin who received telavancin for bronchopulmonary exacerbations.
Semiconductor-inspired design principles for superconducting quantum computing
Creators: name: Shim, Yun-Pil
name: Tahan, Charles
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Superconducting circuits offer tremendous design flexibility in the quantum regime culminating most recently in the demonstration of few qubit systems supposedly approaching the threshold for fault-tolerant quantum information processing. Competition in the solid-state comes from semiconductor qubits, where nature has bestowed some very useful properties which can be utilized for spin qubit based quantum computing. Here we begin to explore how selective design principles deduced from spin-based systems could be used to advance superconducting qubit science. We take an initial step along this path proposing an encoded qubit approach realizable with state-of-the-art tunable Josephson junction qubits. Our results show that this design philosophy holds promise, enables microwave-free control, and offers a pathway to future qubit designs with new capabilities such as with higher fidelity or, perhaps, operation at higher temperature. The approach is also especially suited to qubits based on variable super-semi junctions.
description: 10 pages, 6 figures, accepted version
title: Radiological Findings in Brainstem Infarction Syndromes.
Creators: name: Nix, Janice
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Ischaemia / Infarction
subject: Diagnostic procedure
subject: MR-Diffusion/Perfusion
subject: MR
subject: Neuroradiology brain
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe and illustrate the clinical presentations and imaging findings of the main syndromes associated with brainstem infarcts. Correlation of clinical presentations with specific brainstem structures will facilitate greater understanding of...
Probing equilibrium glass flow up to exapoise viscosities
Creators: name: Pogna, E. A. A.
name: Rodríguez-Tinoco, C.
name: Cerullo, G.
name: Ferrante, C.
name: Rodríguez-Viejo, J.
name: Scopigno, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Glasses are out-of-equilibrium systems aging under the crystallization threat. During ordinary glass formation, the atomic diffusion slows down rendering its experimental investigation impractically long, to the extent that a timescale divergence is taken for granted by many. We circumvent here these limitations, taking advantage of a wide family of glasses rapidly obtained by physical vapor deposition directly into the solid state, endowed with different "ages" rivaling those reached by standard cooling and waiting for millennia. Isothermally probing the mechanical response of each of these glasses, we infer a correspondence with viscosity along the equilibrium line, up to exapoise values. We find a dependence of the elastic modulus on the glass age, which, traced back to temperature steepness index of the viscosity, tears down one of the cornerstones of several glass transition theories: the dynamical divergence. Critically, our results suggest that the conventional wisdom picture of a glass ceasing to flow at finite temperature could be wrong.
description: 4 figures and 1 supplementary figure
(101799) Harriet Sykes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101801) Janet Catherine North
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Simulation Progress and Plans at Rostock / DESY.
Creators: name: Markovik, A.
name: Poplau, G.
name: van Rienen, U.
name: Wanzenberg, R.
name: DESY
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2007

description: Joint CARE-HHH-APD, CARE-ELAN and EUROTEV-WP3 - Workshop on Electron Cloud Clearing ECL2, Geneva, Switzerland, 1 Mar 2007 - 2 Mar 2007
Measured fetal and neonatal exposure to Lumacaftor and Ivacaftor during pregnancy and while breastfeeding
Creators: name: Stringer, E.
name: McKinzie, C.
name: Esther, C.R., Jr
name: Terrell, M.
name: Trimble, A.
Publisher: name: Elsevier B.V.
Year: 2018

description: With the growing class of CFTR modulator therapy available to more patients and with increasing pregnancies in individuals with CF, there is a growing need to understand the effects of these agents during pregnancy. There are few reports of their continued use in the literature, although it is likely that this is not an uncommon occurrence. We report the uncomplicated and successful pregnancy of a woman treated with lumacaftor/ivacaftor, as well as the clinical course of the infant during the first 9 months of life. We also report drug levels in plasma from the mother, cord blood, breast milk, and infant to estimate fetal and infant drug exposure.
Numerical evidence of the double-Griffiths phase of the random quantum Ashkin-Teller chain
Creators: name: Chatelain, Christophe
name: Voliotis, Dimitrios
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The random quantum Ashkin-Teller chain is studied numerically by means of time-dependent Density-Matrix Renormalization Group. The critical lines are estimated as the location of the peaks of the integrated autocorrelation times, computed from spin-spin and polarization-polarization autocorrelation functions. Disorder fluctuations of magnetization and polarization are observed to be maximum on these critical lines. Entanglement entropy leads to the same phase diagram, though with larger Finite-Size effects. The decay of spin-spin and polarization-polarization autocorrelation functions provides numerical evidence of the existence of a double Griffiths phase when taking into account finite-size effects. The two associated dynamical exponents z increase rapidly as the critical lines are approached, in agreement with the recent conjecture of a divergence at the two transitions in the thermodynamic limit.
title: Vascular complications secondary to lumbar disc herniation surgery
Creators: name: Torrez Villarroel, Constanza
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Hernia
subject: Fistula
subject: Blood
subject: Contrast agent-intravenous
subject: Computer Applications-3D
subject: Complications
subject: CT-Angiography
subject: CT
subject: Musculoskeletal spine
subject: Emergency
subject: Arteries / Aorta

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Lumbar disc herniation surgeries are common procedures with good results, nonetheless, they are not exempt from rare and serious complications. The objetives of this paper, is to describe the associated vascular complications, its clinical...
Typicality of thermal equilibrium and thermalization in isolated macroscopic quantum systems
Creators: name: Tasaki, Hal
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Based on the view that thermal equilibrium should be characterized through macroscopic observations, we develop a general theory about typicality of thermal equilibrium and the approach to thermal equilibrium in macroscopic quantum systems. We first formulate the notion that a pure state in an isolated quantum system represents thermal equilibrium. Then by assuming, or proving in certain classes of nontrivial models (including that of two bodies in thermal contact), large-deviation type bounds (which we call thermodynamic bounds) for the microcanonical ensemble, we prove that to represent thermal equilibrium is a typical property for pure states in the microcanonical energy shell. We believe that the typicality, along with the empirical success of statistical mechanics, provides a sound justification of equilibrium statistical mechanics. We also establish the approach to thermal equilibrium under two different assumptions; one is that the initial state has a moderate energy distribution, and the other is the energy eigenstate thermalization hypothesis.
description: 73 pages, 5 figures. Minor improvements have been made in ver 4. References [49] and [62] have been added. The paper will be published in Journal of Statistical Physics
(101802) Robert Henry Otler
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ARDC Planet RDC Ecological and Biodiversity Workshop Report
Creators: name: ARDC Ltd
Publisher: name: Zenodo
Year: 2023
Subjects: trusted data supply chains, planet research data commons, environmental data, Ecological and Biodiversity modelling

description: Research and decision-making about biodiversity increasingly depends on statistical models, whose function is to infer where and when species are likely to be found.
 The ARDC is investigating what digital research infrastructure is needed to support researchers in model development and use, and to foster collaborative networked modelling efforts under the Planet Research Data Commons program.
 In mid-August 2023, 27 ecological modelling experts gathered in Brisbane on Turrbal and Yuggera Country to discuss the digital research infrastructure needed to support researchers developing and using ecological and biodiversity models. The workshop was part of a series of consultations underway for the ARDC’s Planet Research Data Commons (Planet RDC), which is developing national-scale data infrastructure for earth and environmental research and decision-making. The workshop participants represented a wide range of organisations, bringing their insights on the needs of terrestrial biodiversity and ecological modelling across academia, government, nonprofits and national infrastructure facilities. Learn more about the Planet RDC and register your interest at: https://ardc.edu.au/planet-research-data-commons/
title: LeFort classification-from theory to practice
Creators: name: Constantinescu, Nicoleta
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Bones
subject: Trauma
subject: CT
subject: Education
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To present the particularities of Le Fort fractures, but also of specific features shown by Multidetector Computed Tomography (MDCT). The complexity, assimetry and variability of facial fractures. The imput of imaging in choosing the proper...
Iron concentration in exhaled breath condensate decreases in ever-smokers and COPD patients
Creators: name: Madden, M.C.
name: Esther, C.R.
name: McGee, J.
name: Ghio, A.J.
name: Soukup, J.M.
Publisher: name: Institute of Physics Publishing
Year: 2018

description: Investigation employing bronchoalveolar lavage supports both increased and decreased iron concentrations in the epithelial lining fluid (ELF) of smokers. Exhaled breath condensate (EBC) is an alternative approach to sampling the ELF. We evaluated for an association between iron homeostasis and both smoking and a diagnosis of chronic obstructive pulmonary disease (COPD) by measuring metal concentrations in EBC samples from non-smoker controls, smoker controls, and individuals diagnosed with COPD. The total number of EBC specimens was 194. EBC iron and zinc concentrations (mean ±standard error) in the total study population were 0.610 ±0.025 and 40.73 ±1.79 ppb respectively. In linear regressions, total cigarette smoking in pack years showed a significant (negative) relationship with EBC iron concentration but not with EBC zinc concentration. Iron concentrations in EBC from GOLD stage II, III, and IV patients were all significantly decreased relative to those from non-smoker and smoker controls. In contrast to iron, zinc concentrations in EBC were not significantly different than those from non-smoker and smoker controls. It is concluded that smoking decreases EBC iron concentrations and patients diagnosed with COPD have significantly lower EBC iron concentrations. These results likely reflect an increased burden of cigarette smoke particles in the lower respiratory tract of ever-smokers and patients with COPD and the capacity of components in this particle to complex iron.
Excess dimension for secant loci in symmetric products of curves
Creators: name: Aprodu, Marian
name: Sernesi, Edoardo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We extend a result of W. Fulton, J. Harris and R. Lazarsfeld to secant loci in symmetric products of curves. We compare three secant loci and prove the the dimensions of bigger loci can not be excessively larger than the dimension of smaller loci.
description: final version, to appear in Collectanea Math
title: What to analyse and report in imaging of gallbladder wall thickening?
Creators: name: Ifrosa, Mia Madalina
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Biliary Tract / Gallbladder
subject: Abdomen
subject: Ultrasound
subject: CT
subject: MR
subject: Contrast agent-intravenous
subject: Education
subject: Calcifications / Calculi
subject: Inflammation
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1 . To describe and illustrate the radiological features of the various clinical entities that cause thickening of the gallbladder wall. 2 . To list the key points used to establish an imaging diagnosis adapted to every pathology 3 . To recognize...
Outcomes associated with antibiotic regimens for treatment of Mycobacterium abscessus in cystic fibrosis patients
Creators: name: Lin, F.-C.
name: DaCosta, A.
name: Jordan, C.L.
name: Giddings, O.
name: Esther, C.R., Jr.
name: Gilligan, P.
Publisher: name: Elsevier B.V.
Year: 2017

description: Background Mycobacterium abscessus infection is associated with declining lung function in cystic fibrosis (CF), but there is little evidence on clinical efficacy to guide treatment. Methods Retrospective review of 37 CF patients treated for M. abscessus respiratory infection at a single center from 2006 to 2014. Outcomes included change in FEV1 at 30, 60, 90, 180, and 365 days after treatment and clearance of M. abscessus from sputum cultures. Results Lung function was significantly improved after 30 and 60 days of treatment, but not at later time points. Gains were inversely related to starting lung function. Antibiotic choices did not influence outcomes except for greater clearance with clarithromycin. Conclusions Treatment of M. abscessus resulted in short term improvement in lung function that is inversely related to pre-treatment FEV1.
Highlights from the 2016 North American Cystic Fibrosis Conference
Creators: name: Zemanick, E.T.
name: Esther, C.R., Jr.
name: Daines, C.L.
name: Dellon, E.P.
name: Ong, T.
name: Muhlebach, M.S.
name: Kinghorn, B.
Publisher: name: John Wiley and Sons Inc.
Year: 2017

description: The 30th annual North American Cystic Fibrosis Conference (NACFC) was held in Orlando, FL, on October 27-29, 2016. Abstracts were published in a supplement to Pediatric Pulmonology. This review summarizes several major topic areas addressed at the conference: the pathophysiology of cystic fibrosis (CF) lung disease, clinical trials, clinical management issues, and quality improvement. We sought to provide an overview of emerging concepts in several areas of CF research and care, rather than a comprehensive review of the conference. Citations from the conference are by first author and abstract number or symposium number, as designated in the supplement.
(101800) Edward (Sir) Strachey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Topological Microstructure Analysis Using Persistence Landscapes
Creators: name: Dłotko, Paweł
name: Wanner, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: Algebraic Topology (math.AT)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Phase separation mechanisms can produce a variety of complicated and intricate microstructures, which often can be difficult to characterize in a quantitative way. In recent years, a number of novel topological metrics for microstructures have been proposed, which measure essential connectivity information and are based on techniques from algebraic topology. Such metrics are inherently computable using computational homology, provided the microstructures are discretized using a thresholding process. However, while in many cases the thresholding is straightforward, noise and measurement errors can lead to misleading metric values. In such situations, persistence landscapes have been proposed as a natural topology metric. Common to all of these approaches is the enormous data reduction, which passes from complicated patterns to discrete information. It is therefore natural to wonder what type of information is actually retained by the topology. In the present paper, we demonstrate that averaged persistence landscapes can be used to recover central system information in the Cahn-Hilliard theory of phase separation. More precisely, we show that topological information of evolving microstructures alone suffices to accurately detect both concentration information and the actual decomposition stage of a data snapshot. Considering that persistent homology only measures discrete connectivity information, regardless of the size of the topological features, these results indicate that the system parameters in a phase separation process affect the topology considerably more than anticipated. We believe that the methods discussed in this paper could provide a valuable tool for relating experimental data to model simulations.
Clinical outcomes in cystic fibrosis patients with Trichosporon respiratory infection
Creators: name: Plongla, R.
name: Esther, C.R., Jr.
name: Gilligan, P.
name: Kerr, A.
name: Lin, F.-C.
Publisher: name: Elsevier B.V.
Year: 2016

description: Background Relationships between clinical outcomes and novel respiratory pathogens such as Trichosporon are not well understood. Methods Respiratory cultures from CF patients were screened for novel pathogens Trichosporon and Chryseobacterium as well as other pathogens over 28 months. Relationships between microbiologic and clinical data were assessed using univariate and multivariate methods. Results Of 4934 respiratory cultures from 474 CF patients, 37 cultures from 10 patients were Trichosporon positive. Patients with positive Trichosproron cultures had a greater decline in FEV1 over time (− 3.9%/year vs. -1.3%/year, p < 0.05), whereas Chryseobacterium did not influence lung function. These findings were confirmed in multivariate analyses that included age, gender, and other common pathogens as confounders. Treatment of Trichosporon infected patients was associated with improved lung function. Conclusions Trichosporon can be recovered from a small but clinically meaningful fraction of CF patients. The presence of Trichosporon, but not Chryseobacterium, is associated with greater declines in lung function.
title: Three -dimensional transvaginal ultrasonography in imaging mullerian duct anomalies
Creators: name: Vishweswaraiah, Manoj
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genital / Reproductive system female
subject: Genital / Reproductive system female
subject: Ultrasound
subject: Diagnostic procedure
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Spectrum of mullerian duct anomalies (MDA) evaluated using 3-dimensional transvaginal...
title: Peripheral Nerve Tumors: Imaging Features with Intraoperative Correlation
Creators: name: Gedminaite, Aurelija
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal soft tissue
subject: Neuroradiology peripheral nerve
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Neoplasia
subject: Lymphoma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Present a classification of peripheral nerve tumors Illustratively describe the spectrum of involvement on radiological imaging. Supplement the most spectacular cases with intraoperative findings for better understanding of correlation between...
title: Perspectives of fMRI-based brain mapping in orthodontics
Creators: name: Rumshiskaya, Alena
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Outcomes
subject: Image registration
subject: Treatment effects
subject: Outcomes analysis
subject: Normal variants
subject: MR-Functional imaging
subject: Neuroradiology brain
subject: Head and neck

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Possible clinical applications of functional MRI are not limited to neurosurgical planning and neurorehabilitation. New directions include an emerging field of functional neuroimaging in orthodontics. So far, there were a few studies on healthy...
Diagnostic evaluation of infants with recurrent or persistent wheezing
Creators: name: Wilson, K.C.
name: Esther, C.R., Jr.
name: Pittman, J.
name: Thomson, C.C.
name: Papantonakis, C.M.
name: Ren, C.L.
name: Boyer, D.
name: Barsky, E.
Publisher: name: American Thoracic Society
Year: 2016

description: The Pediatric Assembly of the
American Thoracic Society assembled an
interdisciplinary panel to develop clinical
practice guidelines for the evaluation of
infants with recurrent or persistent
wheezing. This summary of the guideline
is intended for practicing clinicians.
Conformal Barrier for New Vector Bosons Decay to the Higgs
Creators: name: Fukano, Hidenori S.
name: Matsuzaki, Shinya
name: Yamawaki, Koichi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The ATLAS collaboration has recently reported excesses about 2.5 sigma at mass around 2 TeV in the diboson channels, which can be identified with new vector bosons as a hint for the new physics. It is shown that spontaneously broken conformal/scale symmetry prohibits new vector bosons decay to the Higgs, which is contrasted to the popular "equivalence theorem" valid only in a special limit not necessarily relevant to the 2 TeV mass. If the decay $V\to WH/ZH$ is not observed in the ongoing Run II of the LHC, then the 125 GeV Higgs can be a dilaton.
description: latex, 4 pages: some corrections made; version published in MPLA, 4 March 2016
Official American thoracic society clinical practice guidelines: Diagnostic evaluation of infants with recurrent or persistent wheezing
Creators: name: Yuksel, H.
name: Yilmaz, O.
name: Ewig, J.M.
name: Debley, J.S.
name: Weinberger, M.
name: Sockrider, M.
name: Teper, A.
name: Ranganathan, S.
name: Radford, P.
name: Esther, C.R.
name: Wilson, K.C.
name: Noah, T.L.
name: Davis, S.D.
name: Bazzy-Asaad, A.
name: Lombardi, E.
name: Ren, C.L.
name: Brozek, J.
name: Amin, N.
name: Durand, M.
Publisher: name: American Thoracic Society
Year: 2016

description: Background: Infantile wheezing is a common problem, but there are no guidelines for the evaluation of infants with recurrent or persistent wheezing that is not relieved or prevented by standard therapies. Methods: An American Thoracic Society-sanctioned guideline development committee selected clinical questions related to uncertainties or controversies in the diagnostic evaluation of wheezing infants. Members of the committee conducted pragmatic evidence syntheses, which followed the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The evidence syntheses were used to inform the formulation and grading of recommendations. Results: The pragmatic evidence syntheses identified few studies that addressed the clinical questions. The studies that were identified constituted very low-quality evidence, consisting almost exclusively of case series with risk of selection bias, indirect patient populations, and imprecise estimates. The committee made conditional recommendations to perform bronchoscopic airway survey, bronchoalveolarlavage,esophagealpHmonitoring,andaswallowing study.Italsomadeconditionalrecommendationsagainstempiricfood avoidance, upper gastrointestinal radiography, and gastrointestinal scintigraphy. Finally, the committee recommended additional research about the roles ofinfantpulmonaryfunction testingand food avoidance or dietary changes, based on allergy testing. Conclusions: Although infantile wheezing is common, there is a paucity of evidence to guide clinicians in selecting diagnostic tests for recurrent or persistent wheezing. Our committee made several conditional recommendations to guide clinicians; however, additional research that measures clinical outcomes is needed to improve our confidence in the effects of various diagnostic interventions and to allow advice to be provided with greater confidence.
Lifetime measurement of the 5d$^2$D$_{5/2}$ state in Ba$^+$
Creators: name: Mohanty, Amita
name: Dijck, Elwin A.
name: Portela, Mayerlin Nuñez
name: Valappol, Nivedya
name: Grier, Andrew T.
name: Meijknecht, Thomas
name: Willmann, Lorenz
name: Jungmann, Klaus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The lifetime of the metastable 5d$^2$D$_{5/2}$ state has been measured for a single trapped Ba$^+$ ion in a Paul trap in Ultra High Vacuum (UHV) in the 10$^{-10}$ mbar pressure range. A total of 5046 individual periods when the ion was shelved in this state have been recorded. A preliminary value $τ_{D_{5/2}} = 26.4(1.7)$~s is obtained through extrapolation to zero residual gas pressure.
description: 6 pages, 6 figures, EXA 2014
title: CT-guided diskolysis with intradiscal injection of Oxygen-Ozone mixture for treatment of herniated lumbar disc. A practical guide for residents.
Creators: name: Giannatempo, Giuseppe
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Hernia
subject: Economics
subject: Treatment effects
subject: Puncture
subject: Cost-effectiveness
subject: CT
subject: Neuroradiology spine
subject: Interventional non-vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this poster is to learn how to perform CT-guided diskolysis with intradiscal injection of oxygen-ozone (O 2 -O 3 ) mixture for treatment of herniated lumbar disc, explaining in detail: Indications and contraindications to treatment....
Helping to Bridge the Communication Gap through Community-Engaged Research Presentations
Creators: name: Pelak, Grace
name: Renner, Barbara Rochen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Academic research presentations help to inform specialized, academic audiences about current research and practice. Academic libraries often support students, faculty, and staff in creating these types of presentations. Recent investment in community-based research approaches, including community based participatory research (CBPR), has led to a growing interest in academic communities to create poster presentations tailored to community audiences. A librarian and a Student Research Assistant will discuss development of a course-integrated instructional session for PhD students learning to present research results to community audiences. This presentation will highlight best practices such as audience considerations, including literacy and health literacy levels; use of plain language; use of clear communication; and use of visuals and infographics. To further aid in dissemination of these resources, an online guide was also created. These principles are not only beneficial for future instruction but may also inform how librarians can effectively communicate with community patrons.
title: Post partum neurological complications: Looking beyond PRES and CVT- A Pictorial review
Creators: name: Chadaga, Harsha
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: CT
subject: Complications
subject: Obstetrics

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to: To enumerate various neurological complications that occurs in postpartum state. To illustrate the imaging spectrum and MRI features of postpartum neurological...