cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication Factor
Creators: name: Slep, Kevin C.
name: Romes, Erin M.
name: Dandulakis, Mary G.
name: Slevin, Lauren K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Centrioles play a key role in nucleating polarized microtubule networks. In actively dividing cells, centrioles establish the bipolar mitotic spindle and are essential for genomic stability. Drosophila anastral spindle-2 (Ana2) is a conserved centriole duplication factor. Although recent work has demonstrated that an Ana2-dynein light chain (LC8) centriolar complex is critical for proper spindle positioning in neuroblasts, how Ana2 and LC8 interact is yet to be established. Here we examine the Ana2-LC8 interaction and map two LC8-binding sites within the central region of Ana2, Ana2M (residues 156–251). Ana2 LC8-binding site 1 contains a signature TQT motif and robustly binds LC8 (KD of 1.1 μm), whereas site 2 contains a TQC motif and binds LC8 with lower affinity (KD of 13 μm). Both LC8-binding sites flank a predicted ∼34-residue α-helix. We present two independent atomic structures of LC8 dimers in complex with Ana2 LC8-binding site 1 and site 2 peptides. The Ana2 peptides form β-strands that extend a central composite LC8 β-sandwich. LC8 recognizes the signature TQT motif in the first LC8 binding site of Ana2, forming extensive van der Waals contacts and hydrogen bonding with the peptide, whereas the Ana2 site 2 TQC motif forms a uniquely extended β-strand, not observed in other dynein light chain-target complexes. Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2 tetramerization, yielding an Ana2M4-LC88 complex. LC8-mediated Ana2 oligomerization probably enhances Ana2 avidity for centriole-binding factors and may bridge multiple factors as required during spindle positioning and centriole biogenesis.
Spatial search by quantum walk is optimal for almost all graphs
Creators: name: Chakraborty, Shantanav
name: Novo, Leonardo
name: Ambainis, Andris
name: Omar, Yasser
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The problem of finding a marked node in a graph can be solved by the spatial search algorithm based on continuous-time quantum walks (CTQW). However, this algorithm is known to run in optimal time only for a handful of graphs. In this work, we prove that for Erdös-Renyi random graphs, i.e.\ graphs of $n$ vertices where each edge exists with probability $p$, search by CTQW is \textit{almost surely} optimal as long as $p\geq \log^{3/2}(n)/n$. Consequently, we show that quantum spatial search is in fact optimal for \emph{almost all} graphs, meaning that the fraction of graphs of $n$ vertices for which this optimality holds tends to one in the asymptotic limit. We obtain this result by proving that search is optimal on graphs where the ratio between the second largest and the largest eigenvalue is bounded by a constant smaller than 1. Finally, we show that we can extend our results on search to establish high fidelity quantum communication between two arbitrary nodes of a random network of interacting qubits, namely to perform quantum state transfer, as well as entanglement generation. Our work shows that quantum information tasks typically designed for structured systems retain performance in very disordered structures.
description: Keywords: Quantum spatial search, quantum walks, quantum state transfer, entanglement generation, random graphs, complex networks. Published version
(3894) Letitia Hamilton Bryson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Performance of Dual-Augmented Lagrangian Method and Common Spatial Patterns applied in classification of Motor-Imagery BCI
Creators: name: Miladinovic, Aleksandar
name: Miloš Ajčević
name: Silveri, Giulia
name: Accardo, Agostino
Publisher: name: figshare
Year: 2020
Subjects: subject: Neuroscience
subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering
subject: 90303 Biomedical Instrumentation
subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Motor-imagery based brain-computer interfaces (MI-BCI) have the potential to become ground-breaking technologies for neurorehabilitation, the reestablishment of non-muscular communication and commands for patients suffering from neuronal disorders and disabilities, but also outside of clinical practice, for video game control and other entertainment purposes. However, due to the noisy nature of the used EEG signal, reliable BCI systems require specialized procedures for features optimization and extraction. This paper compares the two approaches, the Common Spatial Patterns with Linear Discriminant Analysis classifier (CSP-LDA), widely used in BCI for extracting features in Motor Imagery (MI) tasks, and theDual-Augmented Lagrangian (DAL) framework with three different regularization methods: group sparsity with row groups (DAL-GLR), dual-spectrum (DAL-DS) and l1-norm regularization (DAL-L1). The test has been performed on 7 healthy subjects performing 5 BCI-MI sessions each. Thepreliminary results show that DAL-GLR method outperforms standard CSP-LDA, presenting 6.9% lower misclassification error (p-value = 0.008) and demonstrate the advantage of DAL framework for MI-BCI.
Thermodynamics of ideal Fermi gas under generic power law potential in $d$-dimension
Creators: name: Faruk, Mir Mehedi
name: Bhuiyan, G. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Thermodynamics of ideal Fermi gas trapped in an external generic power law potential $U=\sum_{i=1} ^d c_i |\frac{x_i}{a_i}|^{n_i}$ are investigated systematically from the grand thermodynamic potential in $d$ dimensional space. These properties are explored deeply in the degenerate limit ($μ>> K_BT$), where the thermodynamic properties are greatly dominated by Pauli exclusion principle. Pressure and energy along with the isothermal compressibilty is non zero at $T=0K$, denoting trapped Fermi system is quite live even at absolute zero temperature. The nonzero value of compressibilty denotes zero point pressure is not just a constant but depends on volume.
description: arXiv admin note: text overlap with arXiv:1502.07054
Proliferation of metallic domains caused by inhomogeneous heating near the electrically-driven transition in VO$_2$ nanobeams
Creators: name: Singh, Sujay
name: Horrocks, Gregory
name: Marley, Peter M
name: Shi, Zhenzhong
name: Banerjee, Sarbajit
name: Sambandamurthy, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We discuss the mechanisms behind the electrically driven insulator-metal transition in single crystalline VO$_2$ nanobeams. Our DC and AC transport measurements and the versatile harmonic analysis method employed show that non-uniform Joule heating causes phase inhomogeneities to develop within the nanobeam and is responsible for driving the transition in VO$_{2}$. A Poole-Frenkel like purely electric field induced transition is found to be absent and the role of percolation near and away from the electrically driven transition in VO$_{2}$ is also identified. The results and the harmonic analysis can be generalized to many strongly correlated materials that exhibit electrically driven transitions.
MPEC 2023-T242 : 2014 WR365
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Bona fide interaction-driven topological phase transition in correlated SPT states
Creators: name: He, Yuan-Yao
name: Wu, Han-Qing
name: You, Yi-Zhuang
name: Xu, Cenke
name: Meng, Zi Yang
name: Lu, Zhong-Yi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: It is expected that the interplay between non-trivial band topology and strong electron correlation will lead to very rich physics. Thus a controlled study of the competition between topology and correlation is of great interest. Here, employing large-scale quantum Monte Carlo (QMC) simulations, we provide a concrete example of the Kane-Mele-Hubbard (KMH) model on an AA stacking bilayer honeycomb lattice with inter-layer antiferromagnetic interaction. Our simulation identified several different phases: a quantum spin-Hall insulator (QSH), a $xy$-plane antiferromagnetic Mott insulator ($xy$-AFM) and an inter-layer dimer-singlet insulator (dimer-singlet). Most importantly, a bona fide topological phase transition between the QSH and the dimer-singlet insulators, purely driven by the inter-layer antiferromagnetic interaction is found. At the transition, the spin and charge gap of the system close while the single-particle excitations remain gapped, which means that this transition has no mean field analogue and it can be viewed as a transition between bosonic SPT states. At one special point, this transition is described by a $(2+1)d$ $O(4)$ nonlinear sigma model (NLSM) with {\it exact} $SO(4)$ symmetry, and a topological term at {\it exactly} $Θ= π$. Relevance of this work towards more general interacting SPT states is discussed.
description: 14 pages, 12 figures, 1 table, revised version
(3889) Bessie Bryson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Seroincidence of SARS-CoV-2 infection prior to and during the rollout of vaccines in a community-based prospective cohort of U.S. adults
Creators: name: Parcesepe A.M.
name: Zimba R.
name: Grov C.
name: Shen Y.
name: You W.
name: Berry A.
name: Kulkarni S.G.
name: Srivastava A.
name: Nash D.
name: Robertson M.K.M.
name: Mirzayi C.
name: Maroko A.
name: Penrose K.
Publisher: name: Nature Research
Year: 2024

description: This study used repeat serologic testing to estimate infection rates and risk factors in two overlapping cohorts of SARS-CoV-2 N protein seronegative U.S. adults. One mostly unvaccinated sub-cohort was tracked from April 2020 to March 2021 (pre-vaccine/wild-type era, n = 3421), and the other, mostly vaccinated cohort, from March 2021 to June 2022 (vaccine/variant era, n = 2735). Vaccine uptake was 0.53% and 91.3% in the pre-vaccine and vaccine/variant cohorts, respectively. Corresponding seroconversion rates were 9.6 and 25.7 per 100 person-years. In both cohorts, sociodemographic and epidemiologic risk factors for infection were similar, though new risk factors emerged in the vaccine/variant era, such as having a child in the household. Despite higher incidence rates in the vaccine/variant cohort, vaccine boosters, masking, and social distancing were associated with substantially reduced infection risk, even through major variant surges.
Reproductive biology of greater amberjack Seriola dumerili (Risso, 1810) from the Eastern Mediterranean Sea (Tunisia, Gulf of Gabes)
Creators: name: SLEY, Ayda
name: HADJ TAEIB, Aymen
name: JARBOUI, Othman
name: GHORBEL, Mohamed
name: BOUAIN, Abderrahmen
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: In the present study, the reproductive biology of S. dumerili from the gulf of Gabes was studied by measurement of gonadosomatic indices (GSI) and histological examination of gonads. The sex of specimens (N = 282), ranging in length from 13.4 to 155 cm FL (fork length), was determined macroscopically and microscopically and the proportion of males was significantly lower than that of females with a ratio of 1:1.44. The study of maturity stages of oocytes described five point maturity scale proposed for ovarian maturity: (I) immature-resting stage; (II) developing stage; (III) maturing stage; (IV) ripe-spawning stage; (V) spent stage. Testis maturity was classified in four stages. Monthly changes in the gonadosomatic index exhibited higher values between June and July, and the trend was similar for both sexes. The breeding cycle (maturation, ripe-spawning and spent) lasts from May to September and spawning is observed in June and July. Therefore, the first spawning age for greater amberjack in both sexes is same; sizes at 50% maturity were 95.28 ± 4.5 FL50 cm for females and 93.7 ± 5.1 cm FL50 for males.
ANATOMY AND STRUCTURE OF THE DIGESTIVE-TRACT OF A MYTILID FROM DEEP-SEA HYDROTHERMAL VENTS ON THE EAST PACIFIC RISE
Creators: name: Hily, A.
name: Lepennec, M.
name: Prieur, D.
name: Fialamedioni, A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1986

Abstract
Organometal-catalyzed asymmetric Friedel-Crafts reactions
Creators: name: Heravi, Majid Mommahed
name: Vahideh Zadsirjan
name: Baharak Masoumi
name: Heydari, Masumeh
Publisher: name: figshare
Year: 2020
Subjects: subject: 30203 Inorganic Green Chemistry
subject: FOS: Chemical sciences
subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: 30502 Natural Products Chemistry
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30503 Organic Chemical Synthesis
subject: 30303 Optical Properties of Materials

description: The Friedel-Crafts alkylation (F-CA) reaction is a distinct sort of CC bond formations. It is often used for the formation of CC bonds to aromatic rings in organic synthesis. Its enantioselective version frequently provides highly enantiomer as the expected products. Generally, this asymmetric variant of asymmetric Friedel-Craft alkylation (AF-CA) proceeds via an in situ metal catalyzed generation of an enamine as an intermediate. In this report, we are trying to highlight the applications of various optically pure metal catalysts in the AF-CA as a versatile synthetic strategy in asymmetric synthesis. Metal-catalyzed AF-CA was frequently found as an important and decisive step (steps) for the effective asymmetric synthesis of complex molecules, compounds showing interesting diverse biological activities and especially in the total synthesis of naturally occurring compounds with great and various biological and pharmacological properties.
The N-terminal Domain Allosterically Regulates Cleavage and Activation of the Epithelial Sodium Channel
Creators: name: Gentzsch, Martina
name: Dang, Yan L.
name: Stutts, M. Jackson
name: He, Hong
name: Garcia, Guilherme J.M.
name: Kota, Pradeep
name: Dokholyan, Nikolay V.
name: Buchner, Ginka
name: Chakraborty, Hirak
name: Kubelka, Jan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The epithelial sodium channel (ENaC) is activated upon endoproteolytic cleavage of specific segments in the extracellular domains of the α- and γ-subunits. Cleavage is accomplished by intracellular proteases prior to membrane insertion and by surface-expressed or extracellular soluble proteases once ENaC resides at the cell surface. These cleavage events are partially regulated by intracellular signaling through an unknown allosteric mechanism. Here, using a combination of computational and experimental techniques, we show that the intracellular N terminus of γ-ENaC undergoes secondary structural transitions upon interaction with phosphoinositides. From ab initio folding simulations of the N termini in the presence and absence of phosphatidylinositol 4,5-bisphosphate (PIP2), we found that PIP2 increases α-helical propensity in the N terminus of γ-ENaC. Electrophysiology and mutation experiments revealed that a highly conserved cluster of lysines in the γ-ENaC N terminus regulates accessibility of extracellular cleavage sites in γ-ENaC. We also show that conditions that decrease PIP2 or enhance ubiquitination sharply limit access of the γ-ENaC extracellular domain to proteases. Further, the efficiency of allosteric control of ENaC proteolysis is dependent on Tyr370 in γ-ENaC. Our findings provide an allosteric mechanism for ENaC activation regulated by the N termini and sheds light on a potential general mechanism of channel and receptor activation.
MOA-2007-BLG-197: Exploring the brown dwarf desert
Creators: name: Ranc, C.
name: Cassan, A.
name: Albrow, M. D.
name: Kubas, D.
name: Bond, I. A.
name: Batista, V.
name: Beaulieu, J. -P.
name: Bennett, D. P.
name: Dominik, M.
name: Dong, Subo
name: Fouqué, P.
name: Gould, A.
name: Greenhill, J.
name: Jørgensen, U. G.
name: Kains, N.
name: Menzies, J.
name: Sumi, T.
name: Bachelet, E.
name: Coutures, C.
name: Dieters, S.
name: Prester, D. Dominis
name: Donatowicz, J.
name: Gaudi, B. S.
name: Han, C.
name: Hundertmark, M.
name: Horne, K.
name: Kane, S. R.
name: Lee, C. -U.
name: Marquette, J. -B.
name: Park, B. -G.
name: Pollard, K. R.
name: Sahu, K. C.
name: Street, R.
name: Tsapras, Y.
name: Wambsganss, J.
name: Williams, A.
name: Zub, M.
name: Abe, F.
name: Fukui, A.
name: Itow, Y.
name: Masuda, K.
name: Matsubara, Y.
name: Muraki, Y.
name: Ohnishi, K.
name: Rattenbury, N.
name: Saito, To.
name: Sullivan, D. J.
name: Sweatman, W. L.
name: Tristram, P. J.
name: Yock, P. C. M.
name: Yonehara, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present the analysis of MOA-2007-BLG-197Lb, the first brown dwarf companion to a Sun-like star detected through gravitational microlensing. The event was alerted and followed-up photometrically by a network of telescopes from the PLANET, MOA, and uFUN collaborations, and observed at high angular resolution using the NaCo instrument at the VLT. From the modelling of the microlensing light curve, we derived the binary lens separation in Einstein radius units (s~1.13) and a mass ratio of (4.732+/-0.020)x10^{-2}. Annual parallax, lens orbital motion and finite source effects were included in the models. To recover the lens system's physical parameters, we combined the resulting light curve best-fit parameters with (J,H,Ks) magnitudes obtained with VLT NaCo and calibrated using IRSF and 2MASS data. We derived a lens total mass of 0.86+/-0.04 Msun and a lens distance of 4.2+/-0.3 kpc. We find that the companion of MOA-2007-BLG-197L is a brown dwarf of 41+/-2 Mjup observed at a projected separation of 4.3+/-0.1 AU, and orbits a 0.82+/-0.04 Msun G-K dwarf star. We study the statistical properties of this population of brown dwarfs detected by microlensing, transit, radial velocity, and direct imaging (most of these objects orbit solar-type stars), and we performed a two-dimensional, non-parametric probability density distribution fit to the data, which draws a structured brown dwarf landscape. We confirm the existence of a region that is strongly depleted in objects at short periods and intermediate masses (P<30 d, M~30-60 Mjup), but also find an accumulation of objects around P~500 d and M~20 Mjup, as well as another depletion region at long orbital periods (P>500 d) and high masses (M>50 Mjup). While these data provide important clues on mechanisms of brown dwarfs formation, more data are needed to establish their relative importance, in particular as a function of host star mass.
description: 16 pages, 12 figures
(3890) James Bryson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
How to design a genetic mating scheme: a basic training package for Drosophila genetics
Creators: name: Roote, John
name: Prokop, Andreas
Publisher: name: figshare
Year: 2023
Subjects: Biochemistry and cell biology not elsewhere classified
Evolution of developmental systems
Genetics not elsewhere classified

description: Supplementary files for: Roote, J., and Prokop, A. (2013). How to design a genetic mating scheme: a basic training package for Drosophila genetics. G3 (Bethesda) 3, 353-358. Abstract: Drosophila melanogaster is a powerful model organism for biological research. The essential
and common instrument of fly research is genetics, the art of applying Mendelian rules in the specific context of Drosophila with its unique classical genetic tools and the breadth of modern genetic tools and strategies brought in by molecular biology, transgenic technologies and the use of recombinases. Training newcomers to fly genetics is a complex and time-consuming task but too important to be left to chance. Surprisingly, suitable training resources for beginners currently are not available. Here we provide a training package for basic Drosophila genetics, designed to ensure that basic knowledge on all key areas is covered while reducing the time invested by trainers. First, a manual introduces to fly history, rationale for mating schemes, fly handling, Mendelian rules in fly, markers and balancers, mating scheme design, and transgenic technologies. Its self-study is followed by a practical training session on gender and marker selection, introducing to real flies in the laboratory. Next, through self-study of a PowerPoint presentation, trainees are guided step-by-step through a mating scheme. Finally, to consolidate knowledge, trainees are asked to design similar mating schemes reflecting routine tasks in a fly laboratory. This exercise requires individual feedback but also provides unique opportunities for trainers to spot weaknesses and strengths of each trainee and take remedial action. This training package is being successfully applied at the Manchester fly facility (5th link below) and may serve as a model for further training resources covering other aspects of fly research. A light version of the manual for teaching on undergraduate genetics courses or training short-term project students can be accessed through the last link below.
(3891) John Bryson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ON THE VARIATION AND SPECIAL REPRODUCTION HABITS OF AETEA SICA (COUCH)
Creators: name: SIMMA-KRIEG, B.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: This study deals with four points. The habitus of Aetea sica (Couch), the types of variation, the reproduction habits, and a discussion of questions arising from these observations.
The habitus of A. sica was defined by the usual qualitative and quantitative criteria. Examination of numerous colonies showed that four types of variation occur, which coincide only partly with the known qualitative, but not with the quantitative features. The rate of variation of the quantitative features was very high within one colony.
Three of the four types of zooidal variâtes developed different asexual reproductive products, called sacculi, for the forms associated with zooidal types A and B, and apparently consisting of free autozooids for type C. The sacculi and the type C autozooids can be homologized, and their origin and development can be compared. The variation of the zooids appears to be related to the type of substratum.
The Nucleotide-binding Leucine-rich Repeat (NLR) Family Member NLRX1 Mediates Protection against Experimental Autoimmune Encephalomyelitis and Represses Macrophage/Microglia-induced Inflammation
Creators: name: Chou, Wei Chun
name: Gris, Denis
name: Oyama, Yoshitaka
name: Brickey, June
name: Ting, Jenny P.Y.
name: Robbins, Gregory R.
name: Wen, Haitao
name: Eitas, Timothy K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The nucleotide binding domain and leucine-rich repeat-containing (NLR) family of proteins is known to activate innate immunity, and the inflammasome-associated NLRs are prime examples. In contrast, the concept that NLRs can inhibit innate immunity is still debated, and the impact of such inhibitory NLRs in diseases shaped by adaptive immune responses is entirely unexplored. This study demonstrates that, in contrast to other NLRs that activate immunity, NLRX1 plays a protective role in experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis. When compared with wild-type controls, Nlrx1−/− mice have significantly worsened clinical scores and heightened CNS tissue damage during EAE. NLRX1 does not alter the production of encephalitogenic T cells in the peripheral lymphatic tissue, but Nlrx1−/− mice are more susceptible to adoptively transferred myelin-reactive T cells. Analysis of the macrophage and microglial populations indicates that NLRX1 reduces activation during both active and passive EAE models. This work represents the first case of an NLR that attenuates microglia inflammatory activities and protects against a neurodegenerative disease model caused by autoreactive T cells.
MPEC 2023-T243 : 2023 TA8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Nonperturbative signatures in pair production for general elliptic polarization fields
Creators: name: Li, Z. L.
name: Lu, D.
name: Xie, B. S.
name: Shen, B. F.
name: Fu, L. B.
name: Liu, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The momentum signatures in nonperturbative multiphoton pair production for general elliptic polarization electric fields are investigated by employing the real-time Dirac-Heisenberg-Wigner formalism. For a linearly polarized electric field we find that the positions of the nodes in momenta spectra of created pairs depend only on the electric field frequency. The polarization of external fields could not only change the node structures or even make the nodes disappear but also change the thresholds of pair production. The momentum signatures associated to the node positions in which the even-number-photon pair creation process is forbid could be used to distinguish the orbital angular momentum of created pairs on the momenta spectra. These distinguishable momentum signatures could be relevant for providing the output information of created particles and also the input information of ultrashort laser pulses.
description: 8 pages, 4 figures, submitted to Europhysics Letters
ÉTUDE ÉLECTROPHORÉTIQUE ET IMMUNOCHIMIQUE DU SÉRUM D'UN CRUSTACÉ DÉCAPODE MACROPIPUS PUBER (LINNÉ).  APPLICATION A L'IMMUNOCHIMIE SYSTÉMATIQUE DES CRUSTACÉS
Creators: name: GHIDALIA, Walter
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: The electrophoretical and immunochemical study of the serum of Macropipus puber (Linné), a decapod crustacean, reveals about 23 proteic components, which are immunologically different. Several of them contain copper, but they seem not to be all of the hemocyanic kind.
The technique of quantitative precipitation, the most frequently utilised immunochemical process for the taxonomical study of Crustaceans, seems inadequate, because this technique cannot be utilised for the study of complex mixtures. The immunoelectrophoretical analysis of Grabar and Williams seems to be more convenient for this study.
(3888) Letitia [Lettie] Hamilton Melbye Bryson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
LES FONDS DE MAERL DE LA BAIE DE MORLAIX ET LEUR PEUPLEMENT VÉGÉTAL
Creators: name: CABIOCH, Jacqueline
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: Two types of maerl beds have been recognized in the bay of Morlaix: the beds of Lithothamnium corallioides var. corallioid.es, beds of rough sand, in most cases not muddy, and beds of Lithothamnium corallioides var. minima, beds of fine sands, in most cases muddy.
The beds have an epiflora which constitutes in the whole a summer association with Sporochnus pedunculatus and Arthrocladia villosa, analogous to that noticed for the Mediterranean Sea on the beds of gravel and of maerl. The study of the seasonal variations of this epiflora shows during winter a persistance of a permanent micro-population, constituted by very small species and in most cases linked to that type of substratum.
Variations of the nature of the Corallinacea constituting these beds are shown. They are of two types and may be attributed to:
1—the low frequency of reproductory phenomena;
2—to sedimentological modifications occurring in the beds of the neighourhood.
The UvrD303 Hyper-helicase Exhibits Increased Processivity
Creators: name: Matson, Steven W.
name: Meiners, Matthew J.
name: Tahmaseb, Kambiz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: DNA helicases use energy derived from nucleoside 5′-triphosphate hydrolysis to catalyze the separation of double-stranded DNA into single-stranded intermediates for replication, recombination, and repair. Escherichia coli helicase II (UvrD) functions in methyl-directed mismatch repair, nucleotide excision repair, and homologous recombination. A previously discovered 2-amino acid substitution of residues 403 and 404 (both Asp → Ala) in the 2B subdomain of UvrD (uvrD303) confers an antimutator and UV-sensitive phenotype on cells expressing this allele. The purified protein exhibits a “hyper-helicase” unwinding activity in vitro. Using rapid quench, pre-steady state kinetic experiments we show the increased helicase activity of UvrD303 is due to an increase in the processivity of the unwinding reaction. We suggest that this mutation in the 2B subdomain results in a weakened interaction with the 1B subdomain, allowing the helicase to adopt a more open conformation. This is consistent with the idea that the 2B subdomain may have an autoregulatory role. The UvrD303 mutation may enable the helicase to unwind DNA via a “strand displacement” mechanism, which is similar to the mechanism used to processively translocate along single-stranded DNA, and the increased unwinding processivity may contribute directly to the antimutator phenotype.
Export of deep-sea hydrothermal particles, indigenous thermophilic microorganisms and larvae to the surrounding Ocean
Creators: name: LESONGEUR, Françoise
name: BRIAND, Patrick
name: GODFROY, Anne
name: CRASSOUS, Philippe
name: BYRNE, Nathalie
name: KHRIPOUNOFF, Alexis
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: To assess the production and the export of particulate and biological material in deep-sea hydrothermal vents, four moorings with sediment traps and current meters were deployed for 24 days in the Azores Triple Junction (ATJ) region. They were deployed along an axis starting at the base of a hydrothermal vent chimney and ending 1000 m away. The particles sampled at the base of the chimney were characterized by high concentrations in total sulfur (16%) and iron (4%). The particle composition changed drastically with distance from the vent: the sulfur concentration decreased with an increase in clay components. Thermophilic microorganisms were successfully enriched from all the particle samples. Cultured strains were closely related to hydrothermal species, suggesting that viable hydrothermal vent microorganisms can be exported easily from one hydrothermal field to the open ocean. Fauna collected in the trap at the base of the chimney also included the hydrothermal mytilid species Bathymodiolus azoricus (prejuvenile prodissoconch late stage), larval or juvenile polychaetes and two vent gastropod species (Shinkailepas sp. and Phymorhynchus sp.). These organisms were not sampled by the others sediment traps. The most common taxa found in the traps off the vent were polychaetes, euphausiaceans and copepods (harpacticoids, nauplii and calanoids).
Two different topological insulator phases in NaBaBi
Creators: name: Sun, Yan
name: Wang, Qing-Ze
name: Wu, Shu-Chun
name: Felser, Claudia
name: Liu, Chao-Xing
name: Yan, Binghai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: By breaking the inversion symmetry of the three-dimensional Dirac metal Na$_3$Bi, we realize topological insulator (TI) phases in the known compound NaBaBi using $ab~initio$ calculations. Two distinct TI phases emerge: one phase is due to band inversion between the Bi $p$ and Na $s$ bands, and the other phase (under pressure) is induced by inversion of the Bi $p$ and Ba $d$ bands. Both phases exhibit Dirac-cone-type surface states, but they have opposite spin textures. In the upper cone, a left-handed spin texture exists for the $s$-$p$ inverted phase (similar to a common TI, e.g., Bi$_2$Se$_3$), whereas a right-handed spin texture appears for the $p$-$d$ inverted phase. NaBaBi presents a prototype model of a TI that exhibits different spin textures in the same material. In addition, NaBaBi may exhibit the introduction of correlation effects to the topological state owing to the existence of $d$ states in the band inversion.
description: 9 pages, 7 figures
Urzymology: Experimental Access to a Key Transition in the Appearance of Enzymes
Creators: name: Carter, Charles W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Urzymes are catalysts derived from invariant cores of protein superfamilies. Urzymes from both aminoacyl-tRNA synthetase classes possess sophisticated catalytic mechanisms: pre-steady state bursts, significant transition-state stabilization of both amino acid activation, and tRNA acylation. However, they have insufficient specificity to ensure a fully developed genetic code, suggesting that they participated in synthesizing statistical proteins. They represent a robust experimental platform from which to articulate and test hypotheses both about their own ancestors and about how they, in turn, evolved into modern enzymes. They help reshape numerous paradigms from the RNA World hypothesis to protein structure databases and allostery.
Community structure of pelagic copepods in the eastern tropical Pacific Ocean during summer and autumn
Creators: name: LÓPEZ-IBARRA, Gladis A.
name: HERNÁNDEZ-TRUJILLO, Sergio
name: BODE, Antonio
name: ZETINA-REJÓN, Manuel J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: The Eastern Tropical Pacific Ocean (ETPO) is a region of interest for commercial fisheries but is subject to high oceanographic variability, which affects primary and secondary production. Because pelagic copepods contribute significantly to secondary productivity, they were investigated to examine community structure variation both temporally and spatially. Zooplankton samples were collected from August to December 2003 using a bongo net (333 µm in mesh size). Ninety-six zooplankton samples were analysed, recording 94 copepod species from orders Calanoida, Cyclopoida, Harpacticoida and Poecilostomatoida. The study area could be divided into six geographical zones based on the numerically dominant species. The oceanographic conditions were relatively stable during summer and autumn. Total copepod abundance was higher (47,096 to 62,681 ind.100 m-3) in stations near the coast, mostly in southern Baja California and the Gulf of Tehuantepec; the lowest densities were recorded towards the study area's oceanic regions. Similarly, ecological diversity was higher in zones influenced by tropical mass waters. The biogeographical affinity of copepod species was dominated by tropical species (75.5%), whereas subtropical and temperate species were far less abundant (15.7 and 8.6%, respectively).
(3885) Letitia Hamilton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Solution of the inverse spectral problem for a convolution integro-differential operator with Robin boundary conditions
Creators: name: Buterin, S. A.
name: Rivero, A. E. Choque
Publisher: name: arXiv
Year: 2015
Subjects: subject: Spectral Theory (math.SP)
subject: FOS: Mathematics
subject: 34A55, 45J05, 47G20

description: The operator of double differentiation on a finite interval with Robin boundary conditions perturbed by the composition of a Volterra convolution operator and the differentiation one is considered. We study the inverse problem of recovering the convolution kernel along with a coefficient of the boundary conditions from the spectrum. We prove the uniqueness theorem and that the standard asymptotics is a necessary and sufficient condition for an arbitrary sequence of complex numbers to be the spectrum of such an operator. A constructive procedure for solving the inverse problem is given.
description: 10 pages
Association between the polychaete Procerastea halleziana (Polychaeta: Syllidae: Autolytinae) and the hydroid Tubularia crocea (Cnidaria: Hydrozoa) from the Mar del Plata intertidal zone, Argentina
Creators: name: GENZANO, Gabriel N.
name: SAN MARTÍN, Guillermo
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: Clumps of the hydroid Tubularia crocea (Cnidaria, Hydrozoa, Anthomedusae) are substrata for many epizoites,
 among them many species of polychaetes. The most frequently encountered species of polychaete in Tubularia clumps in
 Mar del Plata (Argentina) is the syllid Procerastea halleziana. The main aim of this study was to analyse the annual fre-
 quency and abundance of this polychaete associated with colonies of the tubularid in that area and to describe this species,
 new to Argentina and the Southern Hemisphere. Procerastea halleziana was frequent on Tubularia crocea, with maximun
 prevalences at the end of summer and the beginning of fall (March-April = 53.8–58.3% of the colonies are associated with
 the polychaete) and minimum in winter (August = 23.5%). The highest abundances were found during the warm season, but
 abundances were always low. The polychaetes live inside membranous tubes, which are attached along the stems of the colo-
 ny. They were observed to feed by piercing the wall of hydranths and this relationship appears to be a kind of contramensa-
 lism, + -, with negative effects on the colonies.
New species of Stenhelia (Copepoda, Harpacticoida, Diosaccidae) from the Bohai Sea (China) with notes on subgeneric division and phylogenetic relationships
Creators: name: MU, Fang-Hong
name: HUYS, Rony
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: Two new species of Stenhelia (Copepoda, Harpacticoida, Diosaccidae) are described from subtidal sediments in
 the Bohai Sea, China. The traditional subgeneric division of Stenhelia is abandoned since both subgenera, Stenhelia
 (Stenhelia) and Stenhelia (Delavalia), are polyphyletic taxa. The latter is tentatively upgraded to generic rank pending a
 phylogenetic analysis of the Stenheliinae. The genus Stenhelia is restricted to a core group of species formerly allocated to
 the subgenus Stenhelia (Stenhelia), including S. gibba, S. proxima, S. curviseta, S. divergens, S. peniculata,
S. pubescens and both new species from the Bohai Sea, S. sheni sp. nov. and S. taiae sp. nov., which are most closely related
 to S. pubescens, described from the Sea of Japan. The genus Beatricella, erroneously considered a junior objective synonym
 of Stenhelia, is reinstated to accommodate S. aemula as the type species. The problematic S. asetosa is transferred to a new
 genus Anisostenhelia primarily on account of the sexual dimorphism of the swimming legs and is regarded as the sistergroup
 of Stenhelia. The P1 endopod of the bathyal S. diegensis is reinterpreted and consequently the species is re-assigned to the
 genus Delavalia where it is most closely related to other deepwater species. S. xylophila is designated as the type of a new
 genus Hicksia. Swimming leg morphology suggests a close relationship with Delavalia hanstromi and D. bocqueti,
 indicating at least a dual origin of the 2-segmented P1 endopod in the Stenheliinae.
Protocol of a mixed method research design to study medical respite programs for persons experiencing homelessness
Creators: name: Daaleman T.P.
name: Biederman D.J.
name: Agans R.
name: Gelberg L.
name: Johnson J.
Publisher: name: Public Library of Science
Year: 2024

description: Medical Respite Programs (MRPs) characterize a care model that has been developed to address the health care and social needs of persons experiencing homelessness by providing post-acute hospital care in a safe environment. Although this model has been shown to reduce hospitalizations, improve health outcomes and increase access to health services, prior studies of MRP programs and outcomes have been limited to individual sites and may not generalize to the population of individuals receiving MRP care. This study protocol describes a mixed method design to collect organizational, provider, and patient-level data from a sample of MRPs.
Organocatalyzed Asymmetric Friedel-Crafts Reactions: An Update
Creators: name: Heravi, Majid Mommahed
name: Vahideh Zadsirjan
name: Heydari, Masumeh
name: Baharak Masoumi
Publisher: name: figshare
Year: 2020
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 30299 Inorganic Chemistry not elsewhere classified
subject: 30203 Inorganic Green Chemistry
subject: 30303 Optical Properties of Materials
subject: 30503 Organic Chemical Synthesis
subject: Organic Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry

description: The Friedel‐Crafts alkylation (F‐CA) reaction is a special kind of carbon−carbon bond formations, which is frequently being used for the formation of such bond in some aromatic rings in organic synthesis. Its asymmetric variant gives enantiorich products. Commonly, an in situ organocatalyzed asymmetric Friedel‐Crafts alkylation (AF‐CA) proceeds via generation of an enamine as an intermediate. The organocatalyzed‐AF‐CA was discovered and established in the mid‐1980s and reviewed comprehensively in 2010. In this report, we are trying to update the applications of novel organocatalysts in the AF‐CA as a versatile synthetic strategy, which is frequently used in the effective asymmetric synthesis of complex molecules, pharmaceutically important compounds and most importantly in the total synthesis of biologically active natural products.
QUELQUES OBSERVATIONS SUR L'APPAREIL REPRODUCTEUR MALE ET FEMELLE DE DEROCHEILOCARIS REMANEl DELAMARE ET CHAPPUIS (CRUSTACEA MYSTACOCARIDA)
Creators: name: ZAFFAGNINI, Fulvio
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: In both the sexes of Derocheilocaris remanei there is an impair dorsal gonad, with two genital openings placed on the inner side of the limbs of the third free thoracic segment. The testis consists of about 12 independent follicles, alternatively placed to form a double row.Beside such follicles, a longitudinally lengthened pocket develops, in which the sperms assemble before their emission. In the ovary, the germinal region is placed at the fore end, and behind it, there are the oocytes in different growth stages. At the beginning, the oocytes, without nurse cells and with very few follicle cells, have 6-8 nucleoli of which, during the vitellogenesis, some continue growing and some do not. The oocytes are laid while they are found at the metaphase of the first maturation division.
In the females, the Author has detected an organ with a probable glandular function, placed behind the ovary upon the terminal part of the gut.