cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Considerations for Digitization Requests and Digital Asset Rights of Smithsonian Paleobiology Collections
Creators: name: Nakano, Jessica
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Considerations for Digitization Requests and Digital Asset Rights of Smithsonian Paleobiology Collections by Assistant Registrar, Dept. Of Paleobiology Jessica Nakano of Assistant Registrar, Dept. Of Paleobiology Smithsonian National Museum Of Natural History Washington United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Deinodon horridus Leidy 1856
Creators: name: Leidy, J.
Publisher: name: Zenodo
Year: 1856
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Dinosauria
Deinodon
Deinodon horridus

description: 4. Deinodon horridus, Leidy.
This genus and species are founded on a number of specimens, consisting of fragments of teeth of a saurian reptile, discovered by Dr. Hayden.
Nine of the specimens referred to consist of crowns of teeth or of their summits, which resemble those of Megalosaurus, being compressed conical and curved, and having trenchant, dentated borders. They are generally thicker in relation to their breadth than in Megalosaurus, which might only be a specific distinction, were it not that there are several other teeth in the same collection apparently of the same animal, but quite peculiar in form.
One of the specimens is a curved conical crown, nearly circular in transverse section, having a prominent dentated ridge on each side. A second specimen is a crown, demi-elliptical in transverse section, with the posterior borders dentated. A third specimen is a small fragment of a very large tooth, apparently with nearly the same form as the latter; and a fourth specimen is a portion of the crown of a tooth, demi-elliptical in transverse section, with the posterior borders elevated but not dentated.
Had the different forms of teeth above indicated been obtained from different localities, they might have been referred to at least four distinct genera, but having been discovered together, and possessing the same structural appearances, I suspect them to have belonged to one and the same species.
The largest specimen resembling the teeth of Megalosaurus in its present condition, is 1 1/4 inches long from the apex, 2/3 of an inch broad at base, and 5 lines thick. One of the specimens, which is demi-elliptical in section, is over an inch in length from the apex, 8 lines broad at base, and 3 1/2 lines wide at the posterior surface. Another specimen, apparently with the same form as that just indicated, in its perfect condition appears to have had the crown over two inches in length, nearly an inch in breadth, and about half an inch in width posteriorly.
description: Published as part of Leidy, J., 1856, Notice of remains of extinct reptiles and fishes, discovered by Dr. FV Hayden in the Bad Lands of the Judith River, Nebraska Territory., pp. 72-73 in Proceedings of the Academy of Natural Sciences of Philadelphia 8 on pages 72-73, DOI: 10.5281/zenodo.1038128
Great AI Divides? Automated Decision-Making Technologies and Dreams of Development
Creators: name: Sinanan, Jolynna
name: McNamara, Thomas
Publisher: name: La Trobe
Year: 2024

description: https://www.taylorfrancis.com/books/edit/10.4324/9781003454281/dark-social-toija-cinque-alexia-maddox-robert-gehl
Shenoufe and his eleven family members, Philemon, Apa Nile, Peter, John, Andreas, Phoibammon, Antony, Philip, Chermon, Hermias (Hermini), and Sophia, from Nepaiat, martyred at Bubastis (Nile Delta), ob. 303–311
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: All evidence related to Shenoufe and his eleven family members, Philemon, Apa Nile, Peter, John, Andreas, Phoibammon, Antony, Philip, Chermon, Hermias (Hermini), and Sophia, from Nepaiat, martyred at Bubastis (Nile Delta), ob. 303–311.
Family and practitioner perspectives on telehealth for services to young children with autism
Creators: name: Iacono, Teresa
name: Dissanayake, Cheryl
name: Trembath, David
name: Hudry, Kristelle
name: Erickson, Shane
name: Spong, Jo
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 44
subject: Human society
classificationCode: 4409
subject: Social work
classificationCode: 4601
subject: Applied computing

description: Telehealth offers the potential to address inequalities in autism service access for young children living in regional and rural areas with limited access to autism specialists. Our aim was to explore parent and practitioner uses of technology, and views about telehealth, including perceived barriers, for autism early intervention service delivery in a regional town in Australia. Fifteen mothers and 19 front-line autism practitioners completed surveys distributed by local autism service and support providers in the regional town; eight front-line practitioners from one service participated in interviews. Mothers and practitioners had access to technology that could be used for video-communication, but had little or no experience with telehealth. Mothers appeared more willing to try telehealth for receiving autism services than practitioners appeared to believe, and practitioners preferred to use it for consulting with other professionals and professional development. Barriers to telehealth included limited experience and practitioners not knowing what a telehealth service would look like, poor access to reliable and high speed internet, lack of skill and technical supports, and practitioners believing families preferred face-to-face services. The success of telehealth in this regional town will rely on better infrastructure, and upskilling practitioners in evidence-based autism interventions so they can provide the required support remotely. Use of telehealth to upskill practitioners in evidence-based practice could provide a first step in ensuring equitable access to expert autism services to regional and rural families.
Caveat Usor: Data and Annotation Differences between Drug Target Resources
Creators: name: Southan, Christopher
Publisher: name: Zendo
Year: 2024

description: Presented at BioIT Boston,  April 2024,   Bioinformatics track (recording available for registrants) 

Drug target assessment typically starts with information gathering from major database entries associated with a particular protein. While these generally give a consensus picture, there can be significant differences between them. This work looked at the BACE1 Alzheimer’s target across multiple resources including Guide to Pharmacology, Open Targets, DrugBank, PubChem, BindingDB, DrugCentral, Pharos, PDBe, canSAR.ai, and the Human Protein Atlas. Surprising discordances were discerned, particularly in aligned bioactive chemistry numbers, disease indications tissue expression, and interaction partners. The problems of data circularity, consensus reliability, and date divergence for the same targets will be outlined.
Trigonometric-series solution for analysis of laminated composite beams
Creators: name: Trung-Kien Nguyen
name: Ngoc-Duong Nguyen
name: Vo, Thuc
name: Thai, Huu Tai
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2016 Elsevier Ltd
A new analytical solution based on a higher-order beam theory for static, buckling and vibration of laminated composite beams is proposed in this paper. The governing equations of motion are derived from Lagrange's equations. An analytical solution based on trigonometric series, which satisfies various boundary conditions, is developed to solve the problem. Numerical results are obtained to compare with previous studies and to investigate the effects of length-to-depth ratio, fibre angles and material anisotropy on the deflections, stresses, natural frequencies and critical buckling loads of composite beams with various configurations.
Crocodilus humilis Leidy 1856
Creators: name: Leidy, J.
Publisher: name: Zenodo
Year: 1856
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Crocodilia
Crocodylidae
Crocodilus
Crocodilus humilis

description: 5. Crocodilus humilis, Leidy.
The species is founded on ten specimens of shed crowns of teeth, apparently of a small species of crocodile. The largest specimen is 7 1/2 lines long and 3 1/2 lines in diameter at base, which is nearly circular. Another specimen is 7 lines long and 2 1/2 lines in diameter at base; and a third specimen is 6 lines long and 3 1/2 lines in diameter at base. These are all moderately curved conical, nearly circular in transverse section, with the two usual internal acute ridges, and with the intervening surfaces slightly striate or nearly smooth. The crown of a posterior tooth is compressed, mammillary in form, 2 1/2 lines long and 2 1/2 wide at base, with the summit obtuse, and the sides finely and longitudinally rugose.
description: Published as part of Leidy, J., 1856, Notice of remains of extinct reptiles and fishes, discovered by Dr. FV Hayden in the Bad Lands of the Judith River, Nebraska Territory., pp. 72-73 in Proceedings of the Academy of Natural Sciences of Philadelphia 8 on page 73, DOI: 10.5281/zenodo.1038128
sj-pdf-1-ueg-10.1177_2050640620964132 - Supplemental material for Activities related to inflammatory bowel disease management during and after the coronavirus disease 2019 lockdown in Italy: How to maintain standards of care
Creators: name: Saibeni, Simone
name: Scucchi, Ludovica
name: Dragoni, Gabriele
name: Bezzio, Cristina
name: Miranda, Agnese
name: Ribaldone, Davide Giuseppe
name: Bertani, Angela
name: Bossa, Fabrizio
name: Allocca, Mariangela
name: Buda, Andrea
name: Mocci, Gianmarco
name: Soriano, Alessandra
name: Mazzuoli, Silvia
name: Bertani, Lorenzo
name: Baccini, Flavia
name: Loddo, Erika
name: Privitera, Antonino Carlo
name: Sartini, Alessandro
name: Viscido, Angelo
name: Grossi, Laurino
name: Casini, Valentina
name: Gerardi, Viviana
name: Ascolani, Marta
name: Ruscio, Mirko Di
name: Casella, Giovanni
name: Savarino, Edoardo
name: Stradella, Davide
name: Pumpo, Rossella
name: Cortelezzi, Claudio Camillo
name: Daperno, Marco
name: Ciardo, Valeria
name: Nardone, Olga Maria
name: Caprioli, Flavio
name: Vitale, Giovanna
name: Cappello, Maria
name: Comberlato, Michele
name: Alvisi, Patrizia
name: Festa, Stefano
name: Campigotto, Michele
name: Bodini, Giorgia
name: Balestrieri, Paola
name: Viola, Anna
name: Pugliese, Daniela
name: Armuzzi, Alessandro
name: Fantini, Massimo C
name: Fiorino, Gionata
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-pdf-1-ueg-10.1177_2050640620964132 for Activities related to inflammatory bowel disease management during and after the coronavirus disease 2019 lockdown in Italy: How to maintain standards of care by Simone Saibeni, Ludovica Scucchi, Gabriele Dragoni, Cristina Bezzio, Agnese Miranda, Davide Giuseppe Ribaldone, Angela Bertani, Fabrizio Bossa, Mariangela Allocca, Andrea Buda, Gianmarco Mocci, Alessandra Soriano, Silvia Mazzuoli, Lorenzo Bertani, Flavia Baccini, Erika Loddo, Antonino Carlo Privitera, Alessandro Sartini, Angelo Viscido, Laurino Grossi, Valentina Casini, Viviana Gerardi, Marta Ascolani, Mirko Di Ruscio, Giovanni Casella, Edoardo Savarino, Davide Stradella, Rossella Pumpo, Claudio Camillo Cortelezzi, Marco Daperno, Valeria Ciardo, Olga Maria Nardone, Flavio Caprioli, Giovanna Vitale, Maria Cappello, Michele Comberlato, Patrizia Alvisi, Stefano Festa, Michele Campigotto, Giorgia Bodini, Paola Balestrieri, Anna Viola, Daniela Pugliese, Alessandro Armuzzi, Massimo C Fantini, Gionata Fiorino and on behalf of IG-IBD (Italian Group for the study of Inflammatory Bowel Disease) in United European Gastroenterology Journal
Author_Response_1 – Supplemental material for Risk factors for early readmission after acute exacerbation of chronic obstructive pulmonary disease
Creators: name: Jo, Yong Suk
name: Rhee, Chin Kook
name: Kim, Kyung Joo
name: Yoo, Kwang Ha
name: Park, Yong-Bum
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, Author_Response_1 for Risk factors for early readmission after acute exacerbation of chronic obstructive pulmonary disease by Yong Suk Jo, Chin Kook Rhee, Kyung Joo Kim, Kwang Ha Yoo and Yong-Bum Park in Therapeutic Advances in Respiratory Disease
In vitro and in vivo evaluation of 89Zr-DS-8273a as a theranostic for anti-death receptor 5 therapy
Creators: name: Burvenich, Ingrid
name: Lee, Fook-Thean
name: Guo, N
name: Gan, Hui
name: Rigopoulos, Angela
name: Parslow, Adam
name: O'Keefe, GJ
name: Gong, Sylvia
name: Tochon-Danguy, H
name: Rudd, SE
name: Dormelly, PS
name: Kotsuma, M
name: Ohtsuka, T
name: Senaldi, G
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: Background: DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific binding to DR5. DS-8273a is currently being used in clinical Phase I trials. This study evaluated the molecular imaging of DR5 expression in vivo in mouse tumor models using SPECT/CT and PET/MRI, as a tool for drug development and trial design. Methods: DS-8273a was radiolabeled with indium-111 and zirconium-89. Radiochemical purity, immunoreactivity, antigen binding affinity and serum stability were assessed in vitro. In vivo biodistribution and pharmacokinetic studies were performed, including SPECT/CT and PET/MR imaging. A dose-escalation study using a PET/MR imaging quantitative analysis was also performed to determine DR5 receptor saturability in a mouse model. Results: 111In-CHX-A"-DTPA-DS-8273a and 89Zr-Df-Bz-NCS-DS-8273a showed high immunoreactivity (100%), high serum stability, and bound to DR5 expressing cells with high affinity (Ka, 1.02-1.22 × 1010 M-1). The number of antibodies bound per cell was 32,000. In vivo biodistribution studies showed high and specific uptake of 111In-CHX-A"-DTPA-DS-8273a and 89Zr-Df-Bz-NCS-DS-8273a in DR5 expressing COLO205 xenografts, with no specific uptake in normal tissues or in DR5-negative CT26 xenografts. DR5 receptor saturation was observed in vivo by biodistribution studies and quantitative PET/MRI analysis. Conclusion: 89Zr-Df-Bz-NCS-DS-8273a is a potential novel PET imaging reagent for human bioimaging trials, and can be used for effective dose assessment and patient response evaluation in clinical trials.
In vitro and in vivo evaluation of 89Zr-DS-8273a as a theranostic for anti-death receptor 5 therapy
Creators: name: Burvenich, IJG
name: Lee, Fook-Thean
name: Guo, N
name: Gan, Hui
name: Rigopoulos, Angela
name: Parslow, Adam
name: O'Keefe, GJ
name: Gong, Sylvia
name: Tochon-Danguy, H
name: Rudd, SE
name: Dormelly, PS
name: Kotsuma, M
name: Ohtsuka, T
name: Senaldi, G
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: DS-8273a, an anti-human death receptor 5 (DR5) agonistic antibody, has cytotoxic activity against human cancer cells and induces apoptosis after specific binding to DR5. DS-8273a is currently being used in clinical Phase I trials. This study evaluated the molecular imaging of DR5 expression in vivo in mouse tumor models using SPECT/CT and PET/MRI, as a tool for drug development and trial design. Methods: DS-8273a was radiolabeled with indium-111 and zirconium-89. Radiochemical purity, immunoreactivity, antigen binding affinity and serum stability were assessed in vitro. In vivo biodistribution and pharmacokinetic studies were performed, including SPECT/CT and PET/MR imaging. A dose-escalation study using a PET/MR imaging quantitative analysis was also performed to determine DR5 receptor saturability in a mouse model. Results: 111In-CHX-A"-DTPA-DS-8273a and 89Zr-Df-Bz-NCS-DS-8273a showed high immunoreactivity (100%), high serum stability, and bound to DR5 expressing cells with high affinity (Ka, 1.02-1.22 × 1010 M-1). The number of antibodies bound per cell was 32,000. In vivo biodistribution studies showed high and specific uptake of 111In-CHX-A"-DTPA-DS-8273a and 89Zr-Df-Bz-NCS-DS-8273a in DR5 expressing COLO205 xenografts, with no specific uptake in normal tissues or in DR5-negative CT26 xenografts. DR5 receptor saturation was observed in vivo by biodistribution studies and quantitative PET/MRI analysis. Conclusion: 89Zr-Df-Bz-NCS-DS-8273a is a potential novel PET imaging reagent for human bioimaging trials, and can be used for effective dose assessment and patient response evaluation in clinical trials.
Contribution of undergraduate botanical research on plant species' conservation in a biodiversity hot-spot
Creators: name: Freire-fierro, Alina
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Contribution of undergraduate botanical research on plant species' conservation in a biodiversity hot-spot by Alina Freire-fierro of Utcec Herbarium/universidad Regional Amazonica Ikiam Baños De Agua Santa Ecuador for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
"The Right Way at the Right Time": Insights on the Uptake of Falls Prevention Strategies from People with Dementia and Their Caregivers.
Creators: name: Meyer, Claudia
name: Dow, B
name: Hill, KD
name: Tinney, J
name: Hill, Sophie
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 4205
subject: Nursing
classificationCode: 4206
subject: Public health
classificationCode: 420699
subject: Public health not elsewhere classified

description: Strong evidence exists for effective falls prevention strategies for community-dwelling older people. Understanding the translation of these strategies into practice for people with dementia has had limited research focus. People with dementia desire to have their voice heard, to engage meaningfully in the health-care decision-making process, making it a priority for researchers and practitioners to better understand how to engage them in this process. This paper reports on the qualitative aspects of a series of studies, which aimed to identify the views of people with dementia and their caregivers regarding perceptions of falls prevention and the successes and challenges of adopting falls prevention strategies. Twenty five people with dementia and their caregivers were interviewed in their homes at baseline, and 24 caregivers and 16 people with dementia were interviewed at completion of a 6-month individualized falls prevention intervention. Interviews were audio-recorded, transcribed verbatim, and thematically analyzed. Five themes were identified at baseline: perceptions of falls; caregivers navigating the new and the unpredictable; recognition of decline; health services – the need for an appropriate message; and negotiating respectful relationships. At 6 months, caregivers and people with dementia decided on “what we need to know” with firm views that the information regarding falls risk reduction needed to be in “the right way … at the right time.” Rather than caregivers and people with dementia being only recipients of knowledge, they felt they were “more than just empty vessels to be filled” drawing on a “variety of resources” within their circle of influence to be able to positively “adapt to change.” The voices of people with dementia and their caregivers add an important dimension to understanding the translation of falls prevention knowledge for this population. Insights from this study will enable community care health professionals to understand that people with dementia and their caregivers can, and wish to, contribute to implementing falls prevention strategies through their resourcefulness and inclusion in the therapeutic partnership.
CRYSTAL STRUCTURE OF 4-ETHYL-1,3-OXAZOLIDINE-2-THIONE
Creators: name: Okumura, Hisako
name: Kitoh, Soh-Ichi
name: Suda, Mitsuhiro
name: Honda, Mitsunori
name: Kunimoto, Ko-Ki
Publisher: name: European Chemical Bulletin
Year: 2014

description: The crystal structure of 4-ethyl-1,3-oxazolidine-2-thione, C5H9NOS, has been determined from single crystal X-ray diffraction. This compound crystallizes in the monoclinic system, space group P21/c with the unit cell parameters: a = 8.4988(17) Å, b = 10.2300(15) Å, c = 7.5192(19) Å, β = 96.8299(11) ° and four molecules in the unit cell. In the crystals, a pair of enantiomeric (R)- and (S)-molecules is connected via intermoleculer N1−H···S1 hydrogen bonds of the neighboring thioamide moieties to form a centrosymmetric dimer with an R22(8) graph-set motif.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
Trionyx foveatus Leidy 1856
Creators: name: Leidy, J.
Publisher: name: Zenodo
Year: 1856
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Testudines
Trionychidae
Trionyx
Trionyx foveatus

description: 6. Trionyx foveatus, Leidy.
The species is founded on fragments of several costal and sternal plates. The exterior surface of the eostal plates is eovered with pits, excepting close to the margins; and the pits are small and round at the vertebral extremity, and gradually increase in size outwardly and become antero-posteriorly oblong oval and reniform. A vertebral fragment of a third or fourth costal plate, a little over an inch in length, is 11 lines wide and 2 lines thick. Small fragments of the sternal plates present an exterior surface covered with broken vermicular ridges and tubercles separated by wide intervals. Fragments of a hyposternal plate are 3 lines in thickness.
description: Published as part of Leidy, J., 1856, Notice of remains of extinct reptiles and fishes, discovered by Dr. FV Hayden in the Bad Lands of the Judith River, Nebraska Territory., pp. 72-73 in Proceedings of the Academy of Natural Sciences of Philadelphia 8 on page 73, DOI: 10.5281/zenodo.1038128
title: Front Matter, Table of Contents, Preface, Conference Organization
Creators: name: Roy, Sudeepa
name: Kara, Ahmet
Publisher: name: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
Year: 2025
Subjects: subject: Front Matter
subject: Table of Contents
subject: Preface
subject: Conference Organization
subject: Theory of computation → Complexity theory and logic
subject: Theory of computation → Database theory
subject: Theory of computation → Logic
subject: Theory of computation → Models of computation
subject: Theory of computation → Data structures design and analysis
subject: Theory of computation → Formal languages and automata theory
subject: Information systems → Decision support systems
subject: Information systems → Database query processing
subject: Information systems → Database views
subject: Information systems → Data streams
subject: Information systems → Data management systems
subject: Information systems → Graph-based database models
subject: Information systems → Join algorithms
subject: Information systems → Parallel and distributed DBMSs
subject: Information systems → Query languages
subject: Information systems → Query optimization
subject: Information systems → Relational database model
subject: Information systems → Stream management
subject: Computing methodologies → Logical and relational learning
subject: Computing methodologies → Modeling and simulation
subject: Computing methodologies → Supervised learning
subject: Applied computing → Decision analysis
subject: Mathematics of computing → Combinatorics
subject: Mathematics of computing → Enumeration
subject: Mathematics of computing → Graph theory
subject: Security and privacy → Management and querying of encrypted data

description: Front Matter, Table of Contents, Preface, Conference Organization
description: LIPIcs, Vol. 328, 28th International Conference on Database Theory (ICDT 2025), pages 0:i-0:xx
Supplemental Material, Appendix_1-CRC-Quality_Assessment - Survival Rate of Colorectal Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis
Creators: name: Hossein-Ali Nikbakht
name: Hassanipour, Soheil
name: Shojaie, Layla
name: Mohebat Vali
name: Ghaffari-Fam, Saber
name: Ghelichi-Ghojogh, Mousa
name: Maleki, Zahra
name: Arab-Zozani, Morteza
name: Abdzadeh, Elham
name: Delam, Hamed
name: Salehiniya, Hamid
name: Shafiee, Maryam
name: Mohammadi, Salman
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, Appendix_1-CRC-Quality_Assessment for Survival Rate of Colorectal Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis by Hossein-Ali Nikbakht, Soheil Hassanipour, Layla Shojaie, Mohebat Vali, Saber Ghaffari-fam, Mousa Ghelichi-ghojogh, Zahra Maleki, Morteza Arab-Zozani, Elham Abdzadeh, Hamed Delam, Hamid Salehiniya, Maryam Shafiee and Salman Mohammadi in Cancer Control
CD33-D2 isoform characterization for advancement of its therapeutic potential
Creators: name: Shastri, Vivek M.
name: Madabushi, Srideshikan Sargur
name: Hui, Susanta K.
name: Lamba, Jatinder K.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: While CD33 directed immunotherapies have caught significant interest in recent years, the only approved antibody-drug conjugate targeting this antigen for AML is gemtuzumab ozogamicin, which targets the IgV-domain of CD33. Unfortunately, in its current form, these are not effective in a significant proportion of patients due to the presence of a splicing SNP resulting in the loss of IgV-domain. This, however, can be mitigated by targeting the IgC2-domain of CD33; thus, this study aimed to characterize CD33-D2 isoform using the recently developed CD33-D2-targeting antibody HL2541. Genetically engineered AML cell lines expressing CD33 isoforms were tested for antibody-bound internalization and response to GO in vitro. AML-bearing NSG-SGM3 mice were used to evaluate CD33-D2 localization and targeting by the HL2541 antibody in vivo. HL2541-bound-CD33-D2 is internalized similar to CD33-FL upon binding the antibody component of GO. Co-existence of both isoforms compromises the internalization by >2.5–3-fold for each isoform in the AML cell lines, further resulting in 7–9.5-fold higher IC50 values compared to cells expressing only CD33-FL. Finally, we demonstrate that AML cells expressing CD33-D2 localize to bones in mice and are targeted by HL2541antibody in vivo. The results establish the relevance of targeting IgC domain as an alternative immunotarget to supplement AML chemotherapy. CD33 is a protein found on most cancer cells in people with a type of blood cancer called acute myeloid leukemia (AML). A current treatment called gemtuzumab ozogamicin (GO) targets this protein. GO is made of an antibody that carries a drug to kill cancer cells. When GO sticks to CD33, the protein pulls it inside the cell, which leads to the cell being killed. But for many patients, this does not work well. That is because they have a change in their genes that removes the part of CD33 that GO targets. To solve this problem, we tested a new antibody called HL2541. This new antibody sticks to a different part of CD33. We wanted to see if HL2541 could still attach to and enter AML cells that do not have the part of CD33 targeted by GO. In lab tests, we saw that HL2541 could get inside these cancer cells, just like GO. We also tested it in mice and found that HL2541 could find the cancer cells in the body. These results show that HL2541 can find and enter AML cells with the changed CD33 protein. This means HL2541 might help make a new treatment for patients who do not respond to GO.
Additional file 1 of Multi-locus phylogeny of the catfish genus Ictalurus Rafinesque, 1820 (Actinopterygii, Siluriformes) and its systematic and evolutionary implications
Creators: name: Pérez-Rodríguez, Rodolfo
name: Domínguez-Domínguez, Omar
name: Pedraza-Lara, Carlos
name: Rosas-Valdez, Rogelio
name: Pérez-Ponce de León, Gerardo
name: García-Andrade, Ana Berenice
name: Doadrio, Ignacio
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Supplementary Material 1
SYNTHESIS OF NEW INTERCALATED QUINONES AND THEIR CYTOTOXIC EFFECTS ON CANCER CELL LINES
Creators: name: Dridi, Feyriel
name: Bar, Nathalie
name: Sainte-Catherine, Odile
name: Hachemi, Messaoud
name: Lecouvey, Marc
name: Villemin, Didier
Publisher: name: European Chemical Bulletin
Year: 2014

description: Naphthoquinones with benzofuran or benzodioxan ring were obtained from dichloronaphthoquinone and were fully characterized. The new benzodioxanes were tested on 4 cancer cells and one of them, a derivative from methyl pyrogallate was found very cytotoxic for cancer cells.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
Using Scent Detection Dogs in Conservation Settings: A Review of Scientific Literature Regarding Their Selection.
Creators: name: Beebe, Sarah C
name: Howell, Tiffani
name: Bennett, Pauleen
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3009
subject: Veterinary sciences
subject: FOS: Veterinary sciences

description: Dogs are widely used for scent detection work, assisting in searches for, among other things, missing persons, explosives, and even cancers. They are also increasingly used in conservation settings, being deployed for a range of diverse purposes. Although scent detecting dogs have been used in conservation roles for over 100 years, it is only recently that the scientific literature has begun to document their effectiveness and, importantly, how suitable dogs should initially be selected by organizations wanting to develop a detection program. In this paper, we review this literature, with the aim of extracting information that might be of value to conservation groups considering whether to invest in the use of dogs. We conclude that selection of appropriate dogs is no easy task. While olfactory ability is critical, so also are a range of other characteristics. These include biological, psychological, and social traits. At present, no validated selection tools have been published. Existing organizations have adapted selection instruments from other contexts for their use, but very little published information is available regarding the effectiveness of these instruments in a conservation setting. In the absence of clear guidelines, we urge those wanting to invest in one or more dogs for conservation purposes to proceed with extreme caution and, preferably, under the watchful eyes of an experienced professional.
Supplemental Material, sup_Fig._1_flow - Can Intermittent Pneumatic Compression Reduce the Incidence of Venous Thrombosis in Critically Ill Patients: A Systematic Review and Meta-Analysis
Creators: name: Wang, Yiwei
name: Huang, Dong
name: Wang, Maoyun
name: Liang, Zongan
Publisher: name: SAGE Journals
Year: 2020
Subjects: Cardiology
Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental Material, sup_Fig._1_flow for Can Intermittent Pneumatic Compression Reduce the Incidence of Venous Thrombosis in Critically Ill Patients: A Systematic Review and Meta-Analysis by Yiwei Wang, Dong Huang, Maoyun Wang and Zongan Liang in Clinical and Applied Thrombosis/Hemostasis
Cycloketones as Precursor for Convenient Synthesis of Azolopyrimidines and 5-Arylazothiazoles
Creators: name: Abdelhamid, Abdou Osman
Publisher: name: European Chemical Bulletin
Year: 2014

description: Condensation of sodium (3-oxocycloalkylidene)methenolate with several heterocyclic amines afforded pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives. Also, 2-(2-cycloalkylidenehydrazinyl)-4-substituted-5-(phenyldiazenyl)-thiazole derivatives were synthesized via reaction of hydrazonoyl halides with 2-cycloalkylidene-hydrazinecarbothioamide. Structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, alternative synthethic routes and chemical transformation whenver possible.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
Additional file 1 of Prevalence of neutropenia in US residents: a population based analysis of NHANES 2011–2018
Creators: name: Zhou, Jing
name: Zhou, Nan
name: Liu, Qing
name: Xie, Zhi-Ping
name: Xu, Yun
name: Dai, Si-Cheng
name: Lu, Juan
name: Bao, Zheng-Yang
name: Wu, Li-Da
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
Lepidotus occidentalis Leidy 1856
Creators: name: Leidy, J.
Publisher: name: Zenodo
Year: 1856
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Lepisosteiformes
Bramidae
Lepidotus
Lepidotus occidentalis

description: 7. Lepidotus occidentalis, Leidy.
A species proposed on five specimens of thick lozenge-shaped seales, with the root prolonged in the direction of the long diameter. The enamelled surface of the scales is smooth and shining. The largest one has its sides about 4 lines long, the smallest one about 2 1/2 lines long.
description: Published as part of Leidy, J., 1856, Notice of remains of extinct reptiles and fishes, discovered by Dr. FV Hayden in the Bad Lands of the Judith River, Nebraska Territory., pp. 72-73 in Proceedings of the Academy of Natural Sciences of Philadelphia 8 on page 73, DOI: 10.5281/zenodo.1038128
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF STEROIDAL TETRAZOLES AS ANTIPROLIFERATIVE AND ANTIOXIDANT AGENTS
Creators: name: Uzzaman, Shams
name: Asif, Mohd.
name: Ali, Abad
name: Mashrai, Ashraf
name: Khanam, Hena
name: Sherwani, Asif
name: Owais, Mohammad
Publisher: name: European Chemical Bulletin
Year: 2014

description: A series of steroidal tetrazole derivatives (7-9) has been obtained by facile and convenient method in a two-step process. All the newly synthesized compounds were characterized by means of elemental analyses, IR, 1H NMR, 13C NMR and MS. The mean surface roughness value (Ra) of compound 9 was found to be 10.32 measured with AFM. Lipinski’s ‘Rule of Five’ analysis and biological score predicted higher intrinsic quality and revealed that these compounds possess good passive oral absorption. The antiproliferative activity was tested in vitro against HeLa (cervical cancer), KCL-22 (myeloid leukemia), MDA-MBA-231 (breast cancer) and normal cell lines, PBMCs (blood peripheral mononuclear) by MTT assay. The synthesized compounds exhibited moderate to good activity against the three human cancer cell lines and were found to be nontoxic to the normal cell lines. In addition, the synthesized compounds were tested for their in vitro antioxidant activity by DPPH method in which compound 9 exhibited good antioxidant activity.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
Condition-specific or generic preference-based measures in oncology? A comparison of the EORTC-8D and the EQ-5D-3L
Creators: name: Lorgelly, PK
name: Doble, B
name: Rowen, D
name: Brazier, J
name: Thomas, DM
name: Fox, SB
name: Thorne, H
name: Parisot, JP
name: Doig, K
name: Fellowes, A
name: Dobrovic, Alexander
name: James, PA
name: Lipton, L
name: Ashley, D
name: Hayes, T
name: McMurrick, P
name: Richardson, G
name: Lorgelly, P
name: Lucas, M
name: McNeil, JJ
name: John, T
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems
classificationCode: 44
subject: Human society

description: Purpose: It has been argued that generic health-related quality of life measures are not sensitive to certain disease-specific improvements; condition-specific preference-based measures may offer a better alternative. This paper assesses the validity, responsiveness and sensitivity of a cancer-specific preference-based measure, the EORTC-8D, relative to the EQ-5D-3L. Methods: A longitudinal prospective population-based cancer genomic cohort, Cancer 2015, was utilised in the analysis. EQ-5D-3L and the EORTC QLQ-C30 (which gives EORTC-8D values) were asked at baseline (diagnosis) and at various follow-up points (3 months, 6 months, 12 months). Baseline values were assessed for convergent validity, ceiling effects, agreement and sensitivity. Quality-adjusted life-years (QALYs) were estimated and similarly assessed. Multivariate regression analyses were employed to understand the determinants of the difference in QALYs. Results: Complete case analysis of 1678 patients found that the EQ-5D-3L values at baseline were significantly lower than the EORTC-8D values (0.748 vs 0.829, p < 0.001). While the correlation between the instruments was high, agreement between the instruments was poor. The baseline health state values using both instruments were found to be sensitive to a number of patient and disease characteristics, and discrimination between disease states was found to be similar. Mean generic QALYs (estimated using the EQ-5D-3L) were significantly lower than condition-specific QALYs (estimated using the EORTC-8D) (0.860 vs 0.909, p < 0.001). The discriminatory power of both QALYs was similar. Conclusions: When comparing a generic and condition-specific preference-based instrument, divergences are apparent in both baseline health state values and in the estimated QALYs over time for cancer patients. The variability in sensitivity between the baseline values and the QALY estimations means researchers and decision makers are advised to be cautious if using the instruments interchangeably.
Converging Content Between Archives and Museums Using Existing Resources: T.D.A. Cockerell and the Florissant Fossils
Creators: name: Karim, Talia
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Converging Content Between Archives and Museums Using Existing Resources: T.D.A. Cockerell and the Florissant Fossils by Talia Karim of Cu Museum Of Natural History Longmont United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Soft template synthesis of aza- and thiazametalmacrocyclic compounds  in thin gelatin films
Creators: name: Mikhailov, O. V.
Publisher: name: European Chemical Bulletin
Year: 2014

description: The problems concerned with the processes of template synthesis of 3d-element aza- and thiazametalmacrocyclic complexes that happen in nanoreactors on the basis of thin films metalhexacya-noferrate(II) gelatin-immobilized matrix implants under their contact with water solutions containing various (N,O,S)-donor atomic ligands and organic compounds having one or two carbonyl groups have been considered. It was noted that, in a series of cases, the variety of metalmacrocyclic compounds obtained at template synthesis in such specific conditions considerably differs from that of metalmacrocycles formed at the conditions traditional for chemical synthesis.
description: European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin
An Artificial Intelligence-driven Solution to Promoting Cybersecurity for ADS-B Messages Against Injection Attacks: A Study Conveying Major U.S Commercial Airlines and International Airports
Creators: name: Almughazaz, Kinda Basim
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 460299
subject: Artificial intelligence not elsewhere classified

description: In this study, a solution to detect and classify automatic dependent surveillance-broadcast (ADS-B) message injection cyberattacks is presented. Authentic ADS-B samples from air traffic in proximity to O’Hare International Airport are collected and filtered to eliminate erroneous samples as well as to maintain those only from the five most utilized U.S. commercial airlines. These samples are used to create three simulated message injection cyberattacks: path modification, velocity drift, and ghost injection. Then, both authentic and attack samples are exploited to develop, evaluate, and experimentally validate conventional machine learning detection and classification models. To further evaluate the scalability of such models, authentic and attack samples from ten of the busiest international airports in the U.S are conveyed in their training and development. Resulting evaluation metrics suggest an average validation accuracy (VA), detection rate (DR), misdetection rate (MDR), and false alarm rate (FAR) of 90.9%, 88.5%, 11.5%, and 3.8%, respectively. To improve classification performance, one- and two-dimensional deep learning modeling are proposed while exploring two algorithms for transferring the tabular dataset of authentic and attack samples into images, leading to an average VA greater than 99%, in conjunction with an average DR, MDR, and FAR of 98.9%, 1.1%, and 0.25% respectively. The prediction time of the classifiers is in the millisecond range, suggesting an effective real-time classification solution.
Questionnaire_Haredim_in_EnglishESjune28 – Supplemental material for Public Engagement With Science Among Religious Minorities: Lessons From COVID-19
Creators: name: Myrick, Jessica G.
name: Taragin-Zeller, Lea
name: Rozenblum, Yael
name: Baram-Tsabari, Ayelet
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Science Policy

description: Supplemental material, Questionnaire_Haredim_in_EnglishESjune28 for Public Engagement With Science Among Religious Minorities: Lessons From COVID-19 by Lea Taragin-Zeller, Yael Rozenblum and Ayelet Baram-Tsabari in Science Communication
Supplemental Material, Appendix_A._CARE_Measure - Relationship Between Orthopedic Surgeon’s Empathy and Inpatient Hospital Experience Scores in a Tertiary Care Academic Institution
Creators: name: Dobransky, Johanna
name: Gartke, Kathleen
name: Pacheco-Brousseau, Lissa
name: Spilg, Edward
name: Perreault, Ashley
name: Ameen, Mohammad
name: Finless, Alexandra
name: Beaulé, Paul E.
name: Stephane Poitras
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Medicine

description: Supplemental Material, Appendix_A._CARE_Measure for Relationship Between Orthopedic Surgeon’s Empathy and Inpatient Hospital Experience Scores in a Tertiary Care Academic Institution by Johanna Dobransky, Kathleen Gartke, Lissa Pacheco-Brousseau, Edward Spilg, Ashley Perreault, Mohammad Ameen, Alexandra Finless, Paul E. Beaulé and Stephane Poitras in Journal of Patient Experience
Theoretische Grundlagen Ungeplanter Lösungsorienter Gespräche
Creators: name: Lengyel, Roland
Publisher: name: Zenodo
Year: 2012

description: Keine Beschreibung.
description: + Code Diss LU: hslusa mas lko + Fussnote: Master-Arbeit MAS of Advanced Studies in Lösungs- und Kompetenzorientierung, Hochschule Luzern, 2012
The Smallest Hard Trees
Creators: name: Bodirsky, Manuel
name: Bulín, Jakub
name: Starke, Florian
name: Wernthaler, Michael
Publisher: name: arXiv
Year: 2022
Subjects: subject: Rings and Algebras (math.RA)
subject: Computational Complexity (cs.CC)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: G.2.2
subject: 08A70, 08B05

description: We find an orientation of a tree with 20 vertices such that the corresponding fixed-template constraint satisfaction problem (CSP) is NP-complete, and prove that for every orientation of a tree with fewer vertices the corresponding CSP can be solved in polynomial time. We also compute the smallest tree that is NL-hard (assuming L is not NL), the smallest tree that cannot be solved by arc consistency, and the smallest tree that cannot be solved by Datalog. Our experimental results also support a conjecture of Bulin concerning a question of Hell, Nesetril and Zhu, namely that "easy trees lack the ability to count". Most proofs are computer-based and make use of the most recent universal-algebraic theory about the complexity of finite-domain CSPs. However, further ideas are required because of the huge number of orientations of trees. In particular, we use the well-known fact that it suffices to study orientations of trees that are cores and show how to efficiently decide whether a given orientation of a tree is a core using the arc-consistency procedure. Moreover, we present a method to generate orientations of trees that are cores that works well in practice. In this way we found interesting examples for the open research problem to classify finite-domain CSPs in NL.
SUPPLEMENTARY_MATERIAL - Marital Quality and Well-Being Among Older Adults: A Typology of Supportive, Aversive, Indifferent, and Ambivalent Marriages
Creators: name: Liu, Yingling
name: Upenieks, Laura
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: SUPPLEMENTARY_MATERIAL for Marital Quality and Well-Being Among Older Adults: A Typology of Supportive, Aversive, Indifferent, and Ambivalent Marriages by Yingling Liu and Laura Upenieks in Research on Aging
Management of adults with a tracheostomy: An international survey of speech-language pathologists’ practice
Creators: name: Miles, Anna
name: Wallace, Sarah
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Speech-language pathologists are specialists in communication, swallowing, and weaning as core members of the multidisciplinary tracheostomy team. Inconsistent tracheostomy care is known to result in staff and patient frustration, delayed intervention, and patient harm. Little is known about international speech-language pathology tracheostomy practices. This global survey explored training, clinical practices, perceived knowledge, skills and roles, as well as barriers to change and successes. Questions consisted of likert scale and open-ended questions. 1 458 Speech-language pathologists completed the survey representing six continents and 52 countries. Overall, speech-language pathologists were confident in their knowledge and skills. Tracheostomy teams were viewed as a key facilitator of best care. Access to Flexible Endoscopic Evaluation of Swallowing was variable and considered valuable by all. Four key themes emerged: Knowledge and skills, roles and multidisciplinary tracheostomy team relationships, written documentation and protocols, and access to resources. Multidisciplinary tracheostomy team relationships and being valued as a professional were the most common concerns. Speech-language pathologists had a plethora of successes to share that had changed their workplace. This survey shows speech-language pathologists are aligned internationally with common purpose and values. Speech-language pathologists voiced challenges in multidisciplinary tracheostomy team relationships, standardising practice, and resourcing. Benchmarking is the first step to targeted change and we hope this will support and empowerclinicians to continue to innovate tracheostomy practice.