cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
How Carbon Risk Management is Challenging Corporate Governance of Alberta’s Major Oil Producers during the first stages of Canada’s Energy Transition (2015-2020)
Creators: name: Marino Echegaray, Arturo
Publisher: name: Environmental Design
Year: 2022
Subjects: subject: Carbon Risk Management
subject: Canada's Energy Transition
subject: Corporate Governance Management
subject: Sustainable Energy Development
subject: Environmental, Social and Governance (ESG) Performance
subject: Carbon Awareness & Carbon Risk
subject: Carbon Institutional Pressures
subject: Education--Business
subject: Business Administration--Management
subject: Canadian Studies
subject: Environmental Sciences
subject: Engineering--Environmental

description: My dissertation consists of three connected studies that collaboratively investigate whether carbon-related institutional pressures were generating corporate governance dynamics, how the composition and characteristics of the board of directors were evolving due to carbon risk constrains, and how carbon risk management was influenced by its diverse conceptualization among six case studies of major oil producers of Alberta: Suncor Energy Inc., Imperial Oil Ltd., Cenovus Energy Inc., Husky Energy Inc., Canadian Natural Resources Ltd., and MEG Energy Corp. These companies together concentrate more than 80% of total oil production of the province. This research sheds light on how boards’ carbon awareness, decision making, and responsibilities have been evolving in accordance with increased board members’ acknowledgement of carbon and other environmental constraints during Alberta’s early years of energy transition into clean energy technologies (from 2015 until 2020). This research is qualitative and predominantly descriptive-comparative and uses primary archival data sources such as management circulars/proxy statements, annual reports and financial statements, sustainability reports, and reports to the Carbon Disclosure Project, all of them provided by major oil producers of Alberta. Specialized secondary data sources were also used to provide theoretical frameworks to aid with data interpretation. Databases, such as Capital IQ S&P were used to gather shareholder holdings for each company. Thereby, on the basis of the comprehensive analysis of primary documents of oil companies, complemented with secondary sources, verification and inductive-deductive methodology were used to collect, assess, process, consolidate and analyze variations during the period of study. The findings captured stockholders’ variations, adaptation on board’s composition (knowledge, skills, and functional experience) and trends on characteristics (independence, interlocks, gender, diversity, tenure, and age of board members) as well as evolution of enterprise risk management systems according to conceptualization of carbon risk in the studied companies. Based on the results of this research it appears that corporate governance with increased carbon risk awareness and longer-term environmental perspectives can assist companies of Alberta’s oil industry to enhance effective energy transition processes.
Tea and herbal infusions consumption in Portugal: consumer behaviors
Creators: name: Sousa, A. C.
name: Ribeiro, C.
name: Gonçalves, V. M. F.
name: Pádua, I.
name: Leal, S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Tea and herbal infusions (THIs) consumption is recognized for its beneficial effects, which are attributed to the antioxidant properties of phenolic compounds [1–3].The wide diversity of THIs available in market and the absence or failure in quality control can expose the population to health risks [3]. Moreover, uncontrolled consumption may cause toxicity or lack of the expected benefits. Therefore, an understanding of the THIs consumption and consumer habits will allow adjustments in risk-benefit assessment for vulnerable population. Objective: The main aim was to understand THI consumption in Portugal. Methods: A web-based survey was developed and applied (January-February 2023), using Google forms® platform, after the Ethical Committee approval. Sociodemographic data, type of THIs consumed and brewing were collected. Descriptive statistics was performed using JASP 0.16.1.0. Results: A total of 720 participants completed the online survey, of which 47.2% declared drinking THIs ³2 cups/week (medium consumers) and 17.8% consumed ³2 cups/day (heavy consumers). In the latter, the majority were female (87.5%), of which 51.8% aged 40-60 years. In heavy THI consumers group, 10% were older than 61 years. Among the heavy and medium consumers, herbal Infusions, such as citronella (42.1%) and chamomile (35.7%), were most popular than green tea consumption (22.3%). For THI preparation, mostly of these consumers reported the use of tap water (82%) and bags (56%), but 41% reported the use either bags or leaves. Over 16% of heavy and medium consumers use more product quantity than recommended. Approximately 86% of the heavy and medium consumers indicated that, after boiling, let THIs rest for 5-10 minutes and, 78% removed bag/leave before drinking. Conclusions: Herbal infusions consumption was more frequent than green tea and heavy consumers were mainly older adults. This study contributes with relevant results for future risk–benefit assessments of THIs consumption available in the Portuguese market.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Re-Membering Our Nations: Indigenous Custom Adoption and Determining Belonging Beyond the Indian Act
Creators: name: Wilson, Ariane
Publisher: name: Arts
Year: 2022
Subjects: subject: Indian Act
subject: membership codes
subject: custom adoption
subject: nationhood
subject: peoplehood
subject: kinship
subject: relationality
subject: Indian status
subject: Native American Studies
subject: Political Science
subject: FOS: Political science

description: This is a study and analysis of Indigenous membership and belonging. Specifically, this thesis takes up the historical and contemporary harms of colonialism and the Indian Act (1876) have had on First Nations band membership codes and Indigenous practices of determining belonging. The central task of this study is to determine how Indigenous nations can determine membership and belonging beyond colonial confines. I draw on literature on Indigenous nationhood and peoplehood to develop a framework that outlines pathways for belonging that are embedded within networks of kinship and relationality, rather than the arbitrary boundaries of colonial legislation. Throughout the thesis, I argue that Indigenous custom adoptions, in the way they occur within Indigenous legal, political, and kinship systems, are inherently acts of self-determination and as such, provide insight into how Indigenous nations can move beyond the Indian Act.
title: Основы электроснабжения объектов отрасли
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии рассматриваются электрические нагрузки и их графики, методы расчета электрических нагрузок, коэффициенты, используемые при составлении графиков нагрузки. Подробно описаны внутрицеховое, внутризаводское и внешнее электроснабжение. Рассматриваются электрические сети внутризаводского электроснабжения напряжением выше 1000 В, схемы таких сетей и основное оборудование главных понизительных подстанций. Изложены основы создания систем электроснабжения промышленных предприятий. Особый акцент сделан на электроприемниках промышленных предприятий, показателях надежности электроснабжения и режимах работы электроприемников. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплин «Электроснабжение отрасли», «Внутреннее электроснабжение промышленных и гражданских зданий» по специальности среднего профессионального образования 13.02.10 «Электрические машины и аппараты» и профессии 08.01.17 «Электромонтажник-наладчик». Кроме того, учебное пособие будет полезно всем, кто интересуется данной тематикой.
title: MIRAI Cruise Report MR08-06 Leg1
Creators: name: Abe, Natsue
Publisher: name: JAMSTEC
Year: 2009
Subjects: subject: oceans
subject: Cruise report
subject: R/V MIRAI

description: [CRUISE REPORT] This document is a preliminary report of MR08-06 Leg1 on R/V MIRAI from 2009-01-14 to 2009-03-13.
Predictive Methods for Hawkes Processes in High Frequency Finance
Creators: name: Sjogren, Myles Parker
Publisher: name: Science
Year: 2022
Subjects: subject: limit order book
subject: Hawkes process
subject: stochastic modelling
subject: Mathematics
subject: FOS: Mathematics

description: High frequency financial data is burdened by a near obligatory level of randomness that obfuscates the task of predictive modelling. Given that events in a limit order book can be self-exciting in nature and influenced by many external sources, Hawkes processes are a common choice for modelling limit order book dynamics. Many stochastic models have been proposed to describe empirical order-book dynamics and to build a framework for prediction tasks. In this thesis an evaluation of one such family of models, the General Compound Hawkes Process models, is presented with the goal of forming a basis for practical applications of the model. Also examined is the broader application of Hawkes processes in developing trading signals that consolidate information contained within the order flow of a limit order book. Through this work we show the feasibility of Hawkes process based models by showing that they can be used to create both prognostic short term indicators and systematic long term predictions for the mid-price.
Optimization of a protocol for isolation of immune cells from European seabass (Dicentrarchus labrax)
Creators: name: Salazar-Gutierrez, D.
name: Ferreira, M.
name: Sousa, V.
name: Valente, L. M. P.
name: Correia, A.
name: Gomes, S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: As one of the most important food production sectors worldwide, aquaculture is now invested in developing tools to study fish immunity. Fish health relies heavily on hematopoietic organs (head kidney), but also on intestine. The wide knowledge-gap of the fish immune system coupled with the lack of cell lines to perform in vitro studies poses a barrier to the development of efficient tools to enhance fish immunity. Objective: We optimized the protocol for isolation of immune cells from the head kidney (HK) and posterior intestine (PI) of European seabass, to be used as an in vitro tool to test the impact of environmental contaminants on the fish immune system. Methods: HK and PI of European seabass were collected following the methodology of Park et al. [1]. Tissues were pushed through cell strainers. Cell suspensions were layered on a Percoll gradient of 34%/51% (HK) and 25%/75% (PI) and the intermediate band was thereafter collected. Isolated cells were resuspended in L-15+ media with 10% FBS and allowed to adhere to cell culture dishes for 24-h at 23ºC. Adherent cells were detached with PBS 7 mM EDTA on ice. Isolated cells were analyzed by flow cytometry followed by sorting, using lectins WGA and LEL as markers. The cells’ morphology was assessed using cytospinning followed by diff quick staining. Results: We observed a heterogeneous cell population in HK and PI. A high number of leucocytes was isolated from HK (lymphocytes, neutrophils, and monocytes); while in PI the number of leucocytes was scarce. WGA and LEL markers failed to distinguish the cell populations. Based on their morphology, the adherent cells seemed to be enriched in monocytes and/or macrophages. Conclusions: The development of protocols for isolation and culturing of immune cells can be used as a steppingstone for further studies on fish immunity.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
title: Теория вероятностей и математическая статистика
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии рассматриваются основные понятия, свойства и методы современной теории. Помимо теоретического материала дано большое количество задач, сопровождающихся примерами решений. Цель данного пособия — дать первоначальные знания теории вероятностей, математической статистики и случайных процессов. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплины «Теория вероятностей и математическая статистика» по укрупненной группе специальностей среднего профессионального образования 09.00.00 «Информатика и вычислительная техника». Кроме того, учебное пособие будет полезно студентам других специальностей и направлений, изучающих данную дисциплину.
Critical behavior of the geometrical spin clusters and interfaces in the two-dimensional thermalized bond Ising model
Creators: name: Davatolhagh, S.
name: Moshfeghian, M.
name: Saberi, A. A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The fractal dimensions and the percolation exponents of the geometrical spin clusters of like sign at criticality, are obtained numerically for an Ising model with temperature-dependent annealed bond dilution, also known as the thermalized bond Ising model (TBIM), in two dimensions. For this purpose, a modified Wolff single-cluster Monte Carlo simulation is used to generate equilibrium spin configurations on square lattices in the critical region. A tie-breaking rule is employed to identify non-intersecting spin cluster boundaries along the edges of the dual lattice. The values obtained for the fractal dimensions of the spanning geometrical clusters $D_{c}$, and their interfaces $D_{I}$, are in perfect agreement with those reported for the standard two-dimensional ferromagnetic Ising model. Furthermore, the variance of the winding angles, results in a diffusivity $κ=3$ for the two-dimensional thermalized bond Ising model, thus placing it in the universality class of the regular Ising model. A finite-size scaling analysis of the largest geometrical clusters, results in a reliable estimation of the critical percolation exponents for the geometrical clusters in the limit of an infinite lattice size. The percolation exponents thus obtained, are also found to be consistent with those reported for the regular Ising model. These consistencies are explained in terms of the Fisher renormalization relations, which express the thermodynamic critical exponents of systems with annealed bond dilution in terms of those of the regular model system.
description: 12 pages, 7 figures, accepted for publication in J. Stat. Mech. (2012)
title: Совершенствование процесса бурения и бурового оборудования: автоматизация управления технологическими процессами бурения нефтегазовых скважин
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии рассматриваются основные понятия теории автоматического регулирования; рассматриваются элементы аппаратуры и средства автоматики, буровая контрольно-измерительная аппаратура (БКИА), буровые автоматические системы. Особое внимание уделяется связи БКИА и автоматики с техникой и технологией бурения. Намечаются перспективы развития компьютеризации основного бурового процесса. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплин «Технология бурения нефтяных и газовых скважин», «Обслуживание и эксплуатация бурового оборудования» по специальности среднего профессионального образования 21.02.02 «Бурение нефтяных и газовых скважин». Кроме того, учебное пособие будет полезно всем, кто интересуется данной тематикой.
Metric measure spaces with Riemannian Ricci curvature bounded from below
Creators: name: Ambrosio, Luigi
name: Gigli, Nicola
name: Savaré, Giuseppe
Publisher: name: arXiv
Year: 2011
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 52C23, 49J52, 49Q20, 58J35, 35K90, 31C25

description: In this paper we introduce a synthetic notion of Riemannian Ricci bounds from below for metric measure spaces (X,d,m) which is stable under measured Gromov-Hausdorff convergence and rules out Finsler geometries. It can be given in terms of an enforcement of the Lott, Sturm and Villani geodesic convexity condition for the entropy coupled with the linearity of the heat flow. Besides stability, it enjoys the same tensorization, global-to-local and local-to-global properties. In these spaces, that we call RCD(K,\infty) spaces, we prove that the heat flow (which can be equivalently characterized either as the flow associated to the Dirichlet form, or as the Wasserstein gradient flow of the entropy) satisfies Wasserstein contraction estimates and several regularity properties, in particular Bakry-Emery estimates and the L^\infty-Lip Feller regularization. We also prove that the distance induced by the Dirichlet form coincides with d, that the local energy measure has density given by the square of Cheeger's relaxed slope and, as a consequence, that the underlying Brownian motion has continuous paths. All these results are obtained independently of Poincaré and doubling assumptions on the metric measure structure and therefore apply also to spaces which are not locally compact, as the infinite-dimensional ones
description: (v2) Minor typos, proof of Proposition 2.3, proof of Theorem 4.8: corrected. Proof of Theorem 6.2: corrected and simplified, thanks to the new Lemma 2.8. Lemma 3.6 and 4.6 (of v1) removed, since no more needed
Additional file 1 of Gene Ontology-based function prediction of long non-coding RNAs using bi-random walk
Creators: name: Zhang, Jingpu
name: Zou, shuai
name: Deng, Lei
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The lncRNA2GO-55 dataset. Additional file 1 includes the Gene Ontology (GO) annotations and the associated PubMed IDs for 55 lncRNAs. (DOCX 26 kb)
Comparative investigation of third and fifth harmonic generation in atomic and molecular gases driven by mid-infrared ultrafast laser pulses
Creators: name: Ni, Jielei
name: Yao, Jinping
name: Zeng, Bin
name: Chu, Wei
name: Li, Guihua
name: Zhang, Haisu
name: Jing, Chenrui
name: Chin, See Leang
name: Cheng, Ya
name: Xu, Zhizhan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report on the comparative experimental investigation on third and fifth harmonic generation (THG and FHG) in atomic and molecular gases driven by mid-infrared ultrafast laser pulses at a wavelength of ~1500 nm. We observe that the conversion efficiencies of both the THG and FHG processes saturate at similar peak intensities close to ~1.5\times1014 W/cm2 for argon, nitrogen, and air, whose ionization potentials are close to each other. Near the saturation intensity, the ratio of yields of the FHG and THG reaches ~10-1 for all the gases. Our results show that high-order Kerr effects do exist, whereas they are insufficient to balance the Kerr self-focusing without the assistance of plasma generation.
description: 16 pages, 3 figures
Human melanoma-associated antigens as markers for the study of differentiation in human neuroendocrine tumors
Creators: name: Feyles, Valter
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: RC 280 M37 F49 1989
subject: Antigens - Research
subject: Melanoma - Research

description: Bibliography: p. 258-293.
description: offsite
Impact of cannabidiol on viability of normal and tumorigenic human kidney cells: are the effects serum-dependent?
Creators: name: Sousa, D.
name: Amaro, F.
name: Araújo, A. M.
name: Carvalho, M.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Cannabidiol (CBD), the main non-psychotropic cannabinoid of Cannabis sativa, has several pharmacological actions with therapeutic potential, including antitumor effects [1]; however, its effect on renal cell carcinoma (RCC) is unknown. Considering that recent research suggests that cell culture conditions, particularly the presence of serum in culture medium, may modulate the cannabinoids' antitumor effects [2], the potential influence of this growth supplement on the response to CBD should be explored. Objective: To fill this gap, we investigated the sensitivity of human kidney cells to CBD in different growth conditions. Methods: CBD’s cytotoxic profile was assessed in non-tumoral (HK-2) and tumoral (Caki-1 and 769-P) human renal cell lines, using zero or five percent FBS. The MTT assay was performed at different time-points (24 and 48h) after cells were exposed to a wide range of CBD concentrations (1-100 uM). Results: CBD induced a concentration-dependent decrease in cell viability across all cell lines and conditions. After 24h at 5% FBS, it was found that HK-2 and Caki-1 cells were the most sensitive to CBD toxicity, followed by 769-P cells (IC50 values were respectively 14.5, 14.8, and 20.0 µM). In a serum-free medium, after 24h, IC50 values markedly decreased (5.2, 7.6, and 6.8 µM for HK-2, Caki-1 and 769-P cells, respectively; p<0.004 vs. 5% FBS), demonstrating that FBS has a large impact on cellular sensitivity to CBD. IC50 values obtained for 48h were similar since no time-dependent effect was observed (p>0.05). Conclusions: Our findings support that CBD has in vitro anticancer potential against RCC cells, with greater cytotoxic efficacy in the absence of serum. However, CBD cytotoxicity was not selective for tumoral cells, which may be a significant limitation to its safe use in clinical practice. More research is being conducted to investigate the cell death signaling pathways activated by CBD in each cell line.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
The role of relational efficacy beliefs on adolescent's leisure time physical activity
Creators: name: Wilson, Alexandra Harris
Publisher: name: University of British Columbia
Year: 2012

description: Parents are critical social determinants of the health-related behaviours of adolescents. The foundation that parents provide for a healthy lifestyle is particularly important as those lifestyle choices (e.g., physical activity) become under self-regulatory control during adolescence. The overall purpose of this study was to apply the tripartite model of relational efficacy (Lent & Lopez, 2002) to better understand the extent to which adolescents’ (aged 11-13) perceptions of the family environment predict adolescent leisure time physical activity. Specifically, this study examined how adolescents’ confidence in their parents’ (other-efficacy), adolescents estimation of their parents’ confidence in them (relation-inferred self-efficacy), and adolescents outcome expectations associated with physical activity involvement predict their subsequent involvement in physical activity during their leisure time. Four hundred and two grade 7 students from the Lower Mainland of British Columbia completed a questionnaire at two time points (April and June 2012) to assess the above variables. It was hypothesized that there would be a positive relationship between adolescents’ relational efficacy beliefs towards their parents with leisure time physical activity among adolescents. Structural equation modeling was used to examine model fit to test the different study hypotheses. Results revealed a just identified model that demonstrated that adolescents’ confidence in their fathers’ ability to help them be active was predictive of leisure time physical activity. The results from this research provide greater insights into the predictive effects of parents in relation to young adolescents at a time when physical activity becomes increasingly under voluntary control.
Butylone effects on the behaviour of zebrafish (Danio rerio) larvae
Creators: name: Ribeiro, O.
name: Félix, L.
name: Ribeiro, C.
name: Carrola, J. S.
Publisher: name: Scientific Letters
Year: 2023

description: Background: New psychoactive substances (NPS) represent an increasing human health and environmental concern. Despite the efforts to control their production and consumption, new molecules are identified every year. Consequently, their presence in water bodies has been reported raising concern due to potential negative impacts on non-target species such as fish [1], including the synthetic cathinone butylone (BTL) [2]. No information was found regarding its effects on exposed fish, like Danio rerio. This vertebrate is a valorous animal model in numerous areas of toxicology research, particularly to investigate the potential adverse effects of NPS during early-life stages [3]. Objective: This study aims to assess the potential effects of BTL on zebrafish larvae behaviour. Methods: D. rerio embryos with approximately 3 hours post-fertilization (hpf) were exposed until 96 hpf in triplicate to different concentrations of BTL (0.01, 0.1, 1, 10 and 100 µg/L). At 120 hpf, behavioural parameters were assessed in larvae: speed, distance to the centre of the well, absolute turn angle, total distance moved and active time. Results: Overall, an increase in speed, absolute turn angle and total distance moved was observed for the organisms exposed to the higher concentrations1 and 10 µg/L compared with the control group; however, no statistical differences were observed. Conclusions: No changes were found on swimming behaviour of the larvae exposed at the selected BTL concentrations. Furthermore, these concentrations are much higher than the environmental relevant concentrations (0.01 µg/L) usually found. These findings suggest that the exposure to environmental relevant concentrations of BTL during early life stages should not affect early life stages of wild fish. Further research is necessary to study the effects of BTL on fish under chronic exposure to estimate the potential impacts on wild fish populations and improve risk assessment.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Self-focused attention in depression and its relationship to internal self discrepancies and rumination in decision-making
Creators: name: Frizzell, Beverly Jean
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: BF 575 S75 F733 1990
subject: Decision - making
subject: Alberta - Calgary - Population, Women
subject: Self - perception
subject: Depression, Mental

description: Bibliography: p. 174-199.
description: offsite
Into the Fold. Drawings on the Move from the Sangallo Archive
Creators: name: Donetti, Dario
Publisher: name: Brepols
Year: 2021

description: This chapter proposes a new category for the classification of Renaissance architectural drawings by bringing attention - through a careful selection of examples from the archive of the Sangallo family - to plans, elevations, and surveys that were purposely realized be mailed, as a form of remote control of the building site or a means to share archeological knowledge.
TRASTORNO DEL ESPECTRO DE NEUROMIELITIS OPTICA AQP4 POSITIVO. REPORTE DE UN CASO
Creators: name: Márquez Tumbaco, Nathaly
name: Bedoya Riera, Silvia
name: Sig-Tú Meza, Marcia
name: Icaza Herrera, Stefanía
Publisher: name: Zenodo
Year: 2023

description: enfermedad inflamatoria idiopática desmielinizante del sistema nervioso central, caracterizada por episodios de desmielinización y daño axonal, mediados por inmunidad con compromiso del nervio óptico, médula espinal y cerebro de forma monofásica o en brotes y remisiones, siendo una causa de discapacidad en jóvenes y adultos.
Aunque se debe tener en cuenta el diagnóstico de neuromielitis óptica (NMOSD) independientemente del origen étnico, se cree que la incidencia y prevalencia general de NMOSD es mayor entre los blancos, con las tasas más altas encontradas para los pacientes de ascendencia africana en algunos estudios. Esto contrasta con la esclerosis múltiple, que es más común en caucásicos de ascendencia del norte de Europa.
La proporción de pacientes con NMOSD entre los pacientes con trastornos desmielinizantes inflamatorios varía entre las poblaciones. Si bien la NMOSD representa solo una pequeña proporción de pacientes adultos blancos con trastornos desmielinizantes inflamatorios, la mayoría de los cuales tienen esclerosis múltiple clásica, las tasas son mucho más altas en algunas poblaciones asiáticas.
Durante años esta afección ha sido clasificada como variante opticoespinal de la esclerosis múltiple, pero el descubrimiento de los anticuerpos antiAQP4 ayudó a definir el espectro clínico relacionado a esta enfermedad. Asimismo, dichos anticuerpos se detectan en un alto porcentaje de los pacientes con un primer evento.
title: Литология
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии рассматриваются основные понятия литогенеза, рассмотрены характерные особенности различных видов осадочных пород и условия их образования. Описаны условия возникновения природных резервуаров. Настоящее пособие представляет собой курс лекций по дисциплине «Литология». Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплины «Литология» по специальности среднего профессионального образования 21.02.13 «Геологическая съемка, поиски и разведка месторождений полезных ископаемых». Кроме того, учебное пособие будет полезно студентам других специальностей и направлений, изучающих данную дисциплину.
Metabolic reprogramming of sunitinib- and pazopanib-resistant renal cell carcinoma cells: a metabolomics approach
Creators: name: Amaro, E.
name: Carvalho, M.
name: Bastos, M. L.
name: Guedes De Pinho, P.
name: Pinto, J.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Tyrosine kinase inhibitors (TKIs), such as sunitinib and pazopanib, changed the therapeutic landscape of metastatic renal cell carcinoma (RCC) [1,2]. However, TKIs resistance and disease progression within one year have been observed even in patients who initially respond to treatment [3]. Hence, understanding the metabolic mechanisms associated with TKIs resistance is of utmost importance to reverse this issue and improve RCC treatment guidelines. Objective: This work applied a metabolomics approach to investigate the metabolic dysregulations underlying sunitinib and pazopanib resistance in a metastatic RCC cell line (Caki-1). Methods: Caki-1 cell line was continuously (6 months) exposed to increasing concentrations of sunitinib and pazopanib to induce resistance. Resistance was confirmed through the MTT assay by a 4.9- and 2.8-fold increase in the IC50 values of sunitinib and pazopanib-resistant cells compared with the parental cells, respectively. In the metabolomics assay, eight independent passages were considered for TKI-resistant and parental cells. Intracellular and extracellular metabolites were analyzed by proton nuclear magnetic resonance (1H NMR) spectroscopy. Statistical analysis comprised multivariate and univariate methods, and biological interpretation was performed through pathway analysis. Results: TKIs-resistant cells revealed a common reprogramming in the amino acid, glycerophospholipid, and nicotinate and nicotinamide metabolisms. Sunitinib-resistant cells were also characterized by an enhanced cellular antioxidant capacity supported by a significant increase in the intracellular levels of glutathione and myo-inositol, and a significantly higher uptake of glutamine. On the other hand, pazopanib-resistant cells exhibited marked changes in several metabolites (e.g., glucose, lactate, pyruvate, acetate, succinate, fumarate) participating in energy metabolism. Conclusions: Our findings demonstrate for the first time a distinct pattern of metabolic alterations associated with sunitinib and pazopanib resistance in metastatic RCC cells. Targeting these dysregulations may constitute a promising strategy to restore cell sensitivity to treatment with these TKIs.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
Short Circuits in Thermally Ionized Plasmas: A Mechanism for Intermittent Heating of Protoplanetary Disks
Creators: name: Hubbard, Alexander
name: McNally, Colin
name: Mac Low, Mordecai-Mark
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Many astrophysical systems of interest, including protoplanetary accretion disks, are made of turbu- lent magnetized gas with near solar metallicity. Thermal ionization of alkali metals in such gas exceeds non-thermal ionization when temperatures climb above roughly 1000 K. As a result, the conductiv- ity, proportional to the ionization fraction, gains a strong, positive dependence on temperature. In this paper, we demonstrate that this relation between the temperature and the conductivity triggers an exponential instability that acts similarly to an electrical short, where the increased conductivity concentrates the current and locally increases the Ohmic heating. This contrasts with the resistiv- ity increase expected in an ideal magnetic reconnection region. The instability acts to focus narrow current sheets into even narrower sheets with far higher currents and temparatures. We lay out the basic principles of this behavior in this paper using protoplanetary disks as our example host system, motivated by observations of chondritic meteorites and their ancestors, dust grains in protoplanetary disks, that reveal the existence of strong, frequent heating events that this instability could explain.
description: 9 pages, 6 figures, 1 table Accepted, ApJ
Biological evaluation of new diarylpentanoid analogues for antitumor activity
Creators: name: Castro, E.
name: Moreira, J.
name: Silva, P. M. A.
name: Saraiva, L.
name: Pinto, M.
name: Bousbaa, Hassan
name: Cidade, H.
Publisher: name: Scientific Letters
Year: 2023

description: Background: Cancer is associated with high mortality rates and its incidence worldwide is increasing significantly [1]. Several therapeutic strategies have been used in cancer therapy such as microtu-bule-targeting agents [2]. However, these drugs are highly toxic and are associated with high tumor resistance, making their long-term use unfeasible [3,4]. Therefore, new small molecules that can overcome the disadvantages associated with the drugs currently in use in the clinic are needed. We previously reported the in vitro growth inhibitory effect of the diarylpentanoid BP-M345 on human cancer cells, as well as its cellular mechanism of action [5]. Here, BP-M345 analogues have been syn-thetized in a goal to improve the antimitotic/antitumor efficacy of the original BP-M345. Objective: The present study aimed to characterize BP-M345 analogues regarding their cytotoxic activity and mechanism of action, focusing on their potential as antimitotic agent. Methods: A sulforhodamine B assay was used to determine the GI50 of BP-M345 analogues in different cancer cell lines. To evaluate the antimitotic activity, the mitotic index was determined. In addition, lung cancer cells were exposed to compounds, A sulforhodamine B assay was used to determine the GI50 of BP-M345 analogues in different cancer cell lines. To evaluate the antimitotic activity, the mitotic index was determined. In addition, lung cancer cells were exposed to compounds, for twenty-four or forty- eight hours, and the consequence on spindle morphology, cellular proliferation and cell death were evaluated using the following assays: immunofluorescence, colony-formation assay, and flow cytometry, respectively. Time-lapse microscopy imaging was also performed to follow in real time the cell fate of the compound-treated cells. Results: BP-M345 analogues showed potent growth inhibition activity on cancer cells and exhibited a potent antimitotic activity. Mechanistically, BP-M345 analogues induced perturbation of the mitotic spindles through microtubule instability. Consequently, treated cells exhibit defects in chromosome congression during mitosis, which induced a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by apoptosis. Conclusions: BP-M345 analogues have been shown to be highly potent antimitotic agents, more effective than the original BP-M345 leading to massive cancer cell death.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
title: Электротехника и электроника: электрические машины и трансформаторы
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии изложены описания конструкций электрических машин и трансформаторов, их эксплуатационные свойства, основы теории. Дан перечень лабораторных работ и контрольные вопросы, использующиеся при их защите. Для повышения качества усвоения знаний приведены вопросы и ответы для самопроверки. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплин «Электротехника и электроника», «Электротехника», «Основы электротехники» по укрупненной группе специальностей среднего профессионального образования 13.00.00 «Электро- и теплоэнергетика». Кроме того, учебное пособие будет полезно всем, кто интересуется данной тематикой.
Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells
Creators: name: Silva, João P. N.
name: Monteiro, L.
name: Silva, Patrícia M.A.
name: Bousbaa, Hassan
Publisher: name: Scientific Letters
Year: 2023

description: Background: Head and neck cancer is the seventh most prevalent cancer worldwide and it includes oral cancer [1]. Approximately 90% of all oral cancers are oral squamous cell carcinomas [2,3]. Despite their promising preclinical results, the inhibitors of mitotic kinesins and kinases failed in clinical trials, probably because they are not too effective in inducing apoptosis when used in monotherapy [4,5]. Thus, apoptotic pathway in cell treated with mitotic kinesin and kinase inhibitors may be a strategy to improve the effectiveness of these antimitotic agents. Objective: kinesin spindle protein (KSP) is involved in chromosome segregation and its inhibition results in the formation of monopolar spindles, inducing a mitotic delay. Aurora B is involved in correcting errors in chromosome attachment to the mitotic spindle, and its inhibition leads to mitotic exit with chromosome missegregation. The objective of this study is to assess the antitumor potential of combining a KSP or an Aurora B inhibitor with a BCL-2 family inhibitor in oral cancer. Methods: To evaluate the cytotoxic activity of the inhibitors, the IC50 was determined by the MTT assay. Using the Combenefit software, the combinations corresponding to the lowest concentration of the drugs that resulted in the greatest cytotoxic effect were selected. Cell death was assessed by flow cytometry, using annexinV/PI staining. Cell fate after combination treatment was monitored and characterized by time-lapse microscopy. Results: Both anti-KSP/anti-BCL2 and anti-Aurora B/anti-BCL2 combinations showed synergistic effects with increased cytotoxic activity. The anti-KSP/anti-BCL2 combination showed an exacerbation of apoptosis during mitotic arrest, while the anti-Aurora B/anti-BCL2 combination led to increased postmitotic death. Conclusions: Our data demonstrate that the combination of a BCL2 family inhibitor with either a KSP or an Aurora B inhibitor may be potentially useful as treatment strategies against oral cancer.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
title: Электрические машины и аппараты: общий курс электропривода
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии рассматриваются основные теоретические и практические вопросы электрического привода. Подробно освещены принципы построения механической и электрической частей силового канала электропривода, принципы управления в электроприводе, свойства, характеристики и способы регулирования координат в электроприводах постоянного и переменного тока и вопросы конструирования и правила выполнения электрических схем электропривода. Приведены примеры расчетов электропривода. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплин «Электрические машины и аппараты», «Электротехника и электроника» по специальности среднего профессионального образования 13.02.11 «Техническая эксплуатация и обслуживание электрического и электромеханического оборудования (по отраслям)». Кроме того, учебное пособие будет полезно всем, кто интересуется данной тематикой.
Calculated risks: worker, owner and government attitudes toward safety in the Crow's Nest Pass coal mines, 1900-1915
Creators: name: Green, Julie Anne
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: TN 806 C32 B747 1990
subject: Coal mines and mining - Safety regulations - British Columbia - Crow's Nest Pass
subject: Alberta - Crowsnest Pass area - History
subject: British Columbia - Crowsnest Pass area - History

description: offsite
description: Bibliography: p. 201-204.
Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell killing in 2D and 3D culture systems
Creators: name: Pinto, B.
name: Silva, P.
name: Sarmento, B.
name: Carvalho-Tavares, J.
name: Bousbaa, Hassan
Publisher: name: Scientific Letters
Year: 2023

description: Background: Lung cancer is the leading cause of cancer death worldwide, posing a significant public health challenge [1]. Currently available therapies, when administered as monotherapy, have limited efficacy, high toxicity, and can lead to increased tumor resistance. Overexpression of MPS-1, a protein kinase involved in mitosis, has been observed in various types of tumors. Its inhibition is associated with aberrant chromosome segregation, leading to cell death. Also, overexpression of anti-apoptotic proteins from the BCL-2 family has been reported in different cancer types, and inhibiting them can enhance cancer cell killing [2,3]; Objective: To assess the antitumor potential of combining a MPS-1 inhibitor with a BCL- 2 family inhibitor, in both 2D and 3D lung cancer cells (A549); Methods: MPS-1 mRNA and protein levels were assessed by qRT-PCR and western blot, respectively. In 2D cultures, the compounds cytotoxic activity was evaluated by MTT assay. The effects of the combination (antagonistic/additive/synergistic effects) were determined using the Combenefit software. The cell death was evaluated by TUNEL method and by flow cytometry (annexin V/propidium iodide). To assess the antiproliferative activity, the colony formation assay was performed. In 3D cultures, spheroid viability and apoptosis were determined by CellTiter-Glo assay and annexin V/ propidium iodide labeling, respectively; Results: Our results demonstrated that MPS-1 mRNA and protein levels were increased in A549 cells. Co-treatment of 2D cultures with the MPS-1 inhibitor and the BCL- 2 family inhibitor resulted in various synergistic points. The combination with the lowest pharmacological concentrations inhibited cancer cell proliferation, and induced cell death by apoptosis. The results were confirmed in a 3D spheroid model. Conclusions: Cancer cell killing activity of the MPS-1 inhibitor is enhanced when combined with the BCL- 2 family inhibitor, both in 2D and 3D cultures.
description: Scientific Letters, Vol. 1 No. Sup 1 (2023)
title: Формы и методы контроля качества металлов и сварных конструкций: атлас фотографий дефектов опасных производственных объектов
Creators: name: ELS IPR BOOKS
Publisher: name: Профобразование
Year: 2019

description: В учебном пособии содержатся графическое описание и фотографии дефектов сварных соединений, микроструктуры дефектов основного металла оборудования опасных производственных объектов. Включена информация о причинах образования дефектов, методах их предотвращения и вариантах устранения. Настоящее пособие расширяет разделы «Дефекты сварных соединений», «Дефекты поверхности основного металла» Инструкции по визуальному и измерительному контролю РД 03-606-03. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта среднего профессионального образования. Предназначено для изучения дисциплины «Формы и методы контроля качества металлов и сварных конструкций» по специальности среднего профессионального образования 22.02.06 «Сварочное производство», а также по укрупненной группе специальностей и профессий 15.00.00 «Машиностроение». Кроме того, учебное пособие будет полезно для персонала, сертифицирующегося на I и II уровень квалификации по визуальному и измерительному методу контроля.
m-Liouville theorems and regularity results for elliptic PDEs
Creators: name: Fazly, Mostafa
Publisher: name: University of British Columbia
Year: 2012

description: This thesis which is a compendium of seven papers, focuses on the study of the semilinear elliptic equations and systems, on both bounded and unbounded domains of dimension n, most importantly the Allen-Cahn equation and the De Giorgi’s conjecture (1978). This conjecture brings together two groups of mathematicians: one specializing in nonlinear partial differential equations and another in differential geometry, more specifically on minimal surfaces and constant mean curvature surfaces. De Giorgi conjectured that the monotone and bounded solutions of the Allen-Cahn equation on the whole space of dimension n ≤ 8 must be 1-dimensional solutions. This is known to be true for n ≤ 3 and with extra (natural) assumptions for 4 ≤ n ≤ 8. Motivated by this conjecture, I have introduced two main concepts: The first concept is the “H-monotone solutions” that allows us to formulate a counterpart of the De Giorgi’s conjecture for system of equations stating that the H-monotone and bounded solutions of the gradient systems on the whole space of dimension n ≤ 8 must be 1-dimensional solutions. This seems to be in the right track to extend the De Giorgi's conjecture to systems. The second concept is the “m-Liouville theorem” for m = 0, · · · , n − 1 that allows us to formulate a counterpart of the De Giorgi’s conjecture for equations but this time for higher-dimensional solutions as opposed to 1-dimensional solutions. We use the induction idea that is to use 0-Liouville theorem (0- dimensional solutions) to prove 1-Liouville theorem (1-dimensional solutions) and then to prove (n − 1)- Liouville theorem ((n − 1)-dimensional solutions). The reason that we call this “m-Liouville theorem” is because of the great mathematician Joseph Liouville (1809-1882) who proved a classical theorem in complex analysis stating that "bounded harmonic functions on the whole space must be constant" and constants are 0-dimensional objects. 0-Liouville theorem is at the heart of this thesis and it includes various 0-Liouville theorems for various equations and system. In particular, we give a positive answer to the Henon-Lane-Emden conjecture in dimension three under an extra boundedness assumption. On the other hand, it is well known that there is a close relationship between the regularity of solutions on bounded domains and 0-Liouville theorem for related “limiting equations” on the whole space, via rescaling and blow up procedures. In this direction, we present regularity of solutions for gradient and twisted-gradient systems as well as the uniqueness results for nonlocal eigenvalue problems. The novelty here is a stability inequality for both gradient and twisted-gradient systems that gives us the chance to adjust the known techniques and ideas (for equations) to systems.