cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns
Creators: name: Danhof, Sophia
name: Rasche, Leo
name: Mottok, Anja
name: Steinmüller, Tabea
name: Zhou, Xiang
name: Schreder, Martin
name: Kilian, Teresa
name: Strifler, Susanne
name: Rosenwald, Andreas
name: Hudecek, Michael
name: Einsele, Hermann
name: Gerhard-Hartmann, Elena
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Plasma cells
subject: CD319
subject: CS1
subject: Monoclonal antibody
subject: Extramedullary disease
subject: Antigen loss
subject: DDC 610 / Medicine & health

description: Abstract Extramedullary disease (EMD) represents a high-risk state of multiple myeloma (MM) associated with poor prognosis. While most anti-myeloma therapeutics demonstrate limited efficacy in this setting, some studies exploring the utility of chimeric antigen receptor (CAR)-modified T cells reported promising results. We have recently designed SLAMF7-directed CAR T cells for the treatment of MM. SLAMF7 is a transmembrane receptor expressed on myeloma cells that plays a role in myeloma cell homing to the bone marrow. Currently, the only approved anti-SLAMF7 therapeutic is the monoclonal antibody elotuzumab, but its efficacy in EMD has not been investigated thoroughly. Thus, we retrospectively analyzed the efficacy of elotuzumab-based combination therapy in a cohort of 15 patients with EMD. Moreover, since the presence of the target antigen is an indispensable prerequisite for effective targeted therapy, we investigated the SLAMF7 expression on extramedullary located tumor cells before and after treatment. We observed limited efficacy of elotuzumab-based combination therapies, with an overall response rate of 40% and a progression-free and overall survival of 3.8 and 12.9 months, respectively. Before treatment initiation, all available EMD tissue specimens (n = 3) demonstrated a strong and consistent SLAMF7 surface expression by immunohistochemistry. Furthermore, to investigate a potential antigen reduction under therapeutic selection pressure, we analyzed samples of de novo EMD (n = 3) outgrown during elotuzumab treatment. Again, immunohistochemistry documented strong and consistent SLAMF7 expression in all samples. In aggregate, our data point towards a retained expression of SLAMF7 in EMD and encourage the development of more potent SLAMF7-directed immunotherapies, such as CAR T cells.
Stone-based huts and other structures at Smithy Beck, Ennerdale.
Creators: name: Fletcher, W
name: Fell, Clare I
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 27-36
description: Records a group of a dozen rectangular huts in walled enclosures, perhaps shielings, and a ?funerary cairn. Some late or postmed pottery.
Results of Survey Work carried out in the Caldbeck Fells, Cumbria.
Creators: name: Turner, V E
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 19-26
description: Mapping of fourteen sites comprising 190 monuments, mostly cairns, banks and lynchets.
The Production and Distribution of Beehive Querns in Cumbria - Some Initial Considerations.
Creators: name: Ingle, Caroline J
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 11-18
description: Discusses the shape and lithology of thirty-three specimens (Millstone Grit, Penrith Sandstone, and granite erratics). Centres of production can be seen to exist, though scale and date span are unknown; some could be much later than Iron Age.
Prehistoric Habitation Sites in West Cumbria. Part V: Eskmeals to Haverigg.
Creators: name: Cherry, Joyce
name: Cherry, Peter J
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 87, 1-10
description: Last in this series: artefacts recovered were mostly Neolithic to Bronze Age, Mesolithic being either eroded away or (more likely) never present. The pollen evidence is for a 3000 BC start for agriculture.
ESM_text_Tradition and problem solving from The effects of tradition on problem solving by two wild populations of bearded capuchin monkeys in a probing task
Creators: name: Cardoso, Raphael Moura
name: Ottoni, Eduardo B.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Figures and Tables
Understanding Leadership in Agile Software Development Teams: Who and How?
Creators: name: Weichbrodt, Johann
name: Kropp, Martin
name: Biddle, Robert
name: Gregory, Peggy
name: Anslow, Craig
name: Bühler, Ursina Maria
name: Mateescu, Magdalena
name: Meier, Andreas
Publisher: name: Springer
Year: 2022
Subjects: subject: 005 - Computer Programmierung, Programme und Daten

description: The principles in the Agile Manifesto, the Scrum Guide and most other approaches to agile software development emphasize self-organizing teams, but rarely address issues of leadership. In this paper we report on a study of the nature of different aspects of leadership in agile teams. We used an established model of leadership, distinguishing transactional and transformational styles, and asked IT professionals a set of questions about the leadership they experience, both from direct supervisors (hierarchical leadership) and from the team itself (shared leadership). We determined correlation measures of these four types of leadership with the extent of agility in the whole organization. Our results show that agility is indeed related to the transformational style, but that the transactional style also plays a part, especially as shared leadership. Furthermore, even in highly agile software development, leadership by direct supervisors still plays an important role. We propose that, as software development becomes more agile, the transactional aspects of leadership may shift away from the leadership dyad between supervisor and employee into the agile team, while transformational leadership is important for both the team and supervisors. We discuss our results in light of applications for both research and practice.
The 17th-century bloomery at Muncaster Head.
Creators: name: Tylecote, R F
name: Cherry, James
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 70, 69-109
description: SD 141989. Excavation of the site of the bloomery built in Eskdale, Cumberland by William Wright and William Pennington in 1636-7 showed that local ore was smelted using water-power for bellows and hammer. The head race and its sluice-gate were the most clearly-surviving features, but enough remained of the channel alongside the bloomery site to estimate the sizes and power of the water wheels. Although the hearths had been destroyed, furnace bottoms of slag to which some iron adhered gave a fair indication of the process and product in the middle of the 17th century. Later, but probably before the 1720s, the furnaces were lined with cast iron plates. D W C
title: Schöne Revolution. Aktuelle Perspektiven auf Alexandra Kollontai
Creators: name: Beaufaÿs, Sandra
Publisher: name: DuEPublico
Year: 2024
Subjects: classificationCode: 5
subject: FOS: Social sciences
subject: Gender Studies

description: Was sagen uns heute Leben und Werk einer russischen Adeligen, die in der Arbeiter:innenbewegung zu Beginn des 20. Jahrhunderts aktiv und eine der zentralen Akteur:innen der Oktoberrevolution war? Nachdem die Rezeption von Alexandra Kollontais (1872–1952) Schriften ab den 1970er-Jahren nachließ, wird aktuell das Interesse an ihrer Person und ihren Ideen wieder wach. Dabei fasziniert die Figur der Revolutionärin nicht nur in historischer Rückschau, sondern dient auch als Projektionsfläche für aktuelle feministische Visionen.
title: Coûts et financement des transports en 2021
Creators: name: Office fédéral de la statistique
Publisher: name: Office fédéral de la statistique
publisherIdentifier: https://ror.org/027h8t796
publisherIdentifierScheme: ROR
Year: 2024

description: À combien s'élèvent au total les coûts engendrés par les transports en Suisse, qu'est-ce qui est à l'origine de ces coûts et qui les a pris en charge? La présente publication répond à ces questions ainsi qu'à d'autres en considérant le transport routier motorisé, le rail, la mobilité douce, l'aviation et la navigation. Sont pris en compte non seulement les dépenses monétaires pour les véhicules, les infrastructures mais également les coûts immatériels générés par exemple par les dommages dus aux accidents et les atteintes à l'environnement ou à la santé.
Supporting Information: contains supplementary or supporting methods and figures from Deciphering a survival strategy during the interspecific competition between Bacillus cereus MSM-S1 and Pseudomonas sp. MSM-M1
Creators: name: Brinta Chakraborty
name: Anish Mallick
name: Sumana Annagiri
name: Supratim Sengupta
name: Sengupta, Tapas K.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Interspecific competition in bacteria governs colony growth dynamics and pattern formation. Here, we demonstrate an interesting phenomenon of interspecific competition between Bacillus cereus MSM-S1 and Pseudomonas sp. MSM-M1, where secretion of an inhibitor by Pseudomonas sp. is used as a strategy for the survival. Although B. cereus grows faster than Pseudomonas sp.; in the presence of Pseudomonas sp., the population of B. cereus reduces significantly, whereas Pseudomonas sp. do not show any marked alteration in their population growth. Appearance of a zone of inhibition between growing colonies of two species on nutrient agar prevents the expanding front of the MSM-S1 colony from accessing and depleting nutrients in the region occupied by MSM-M1, thereby aiding the survival of the slower growing MSM-M1 colonies. To support our experimental results, we present simulations, based on a chemotactic model of colony growth dynamics. We demonstrate that the chemical(s) secreted by Pseudomonas sp. is responsible for the observed inhibition of growth and spatial pattern of the B. cereus MSM-S1 colony. Our experimental results are in excellent agreement with the numerical results and confirm that secreted inhibitors enable Pseudomonas sp. to survive and coexist in the presence of faster growing B. cereus, in a common niche.
Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas
Creators: name: Pasternack, Helen
name: Kuempers, Christiane
name: Deng, Mario
name: Watermann, Iris
name: Olchers, Till
name: Kuehnel, Mark
name: Jonigk, Danny
name: Kugler, Christian
name: Stellmacher, Florian
name: Goldmann, Torsten
name: Kirfel, Jutta
name: Ammerpohl, Ole
name: Perner, Sven
name: Reck, Martin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Cancer epigenetics
subject: Cancer genetics
subject: Lung cancer
subject: DDC 610 / Medicine & health

description: Abstract The only potentially curative treatment for lung adenocarcinoma patients remains complete resection of early-stage tumors. However, many patients develop recurrence and die of their disease despite curative surgery. Underlying mechanisms leading to establishment of systemic disease after complete resection are mostly unknown. We therefore aimed at identifying molecular signatures of resected lung adenocarcinomas associated with the risk of an early relapse. The study comprised 89 patients with totally resected stage IA–IIIA lung adenocarcinomas. Patients suffering from an early relapse within two years after surgery were compared to patients without a relapse in two years. Patients were clinically and molecular pathologically characterized. Tumor tissues were immunohistochemically analyzed for the expression of Ki67, CD45, CD4, CD8, PD1, PD-L1, PD-L2 and CD34, by Nanostring nCounter PanCancer Immune Profiling Panel as well as a comprehensive methylome profiling using the Infinium MethylationEPIC BeadChip. We detected differential DNA methylation patterns as well as significantly differentially expressed genes associated with an early relapse after complete resection. Especially, CD1A was identified as a potential biomarker, whose reduced expression is associated with an early relapse. These findings might help to develop biomarkers improving risk assessment and patient selection for adjuvant therapy as well as establish novel targeted therapeutic strategies.
CRISPR-Cas: In Rekordzeit von der Grundlagenforschung zur Anwendung
Creators: name: Marchfelder, Anita
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Life Sciences, general
subject: Biochemistry, general
subject: Pharmacology/Toxicology
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 570 / Life sciences
subject: Human genetics
subject: Microbiology
subject: FOS: Biological sciences
subject: Humangenetik
subject: Mikrobiologie

description: Den diesjährigen Nobelpreis für Chemie erhielten die beiden Forscherinnen Emmanuelle Charpentier und Jennifer Doudna für die Entdeckung des Genome Editing. Zum ersten Mal überhaupt in der Geschichte dieses Preises wurde er nur an Wissenschaftlerinnen verliehen.
Roman sites on the Cumberland Coast 1968-1969.
Creators: name: Bellhouse, Richard L
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 70, 9-47
description: Investigation of MF 20 and 22 (and 16) allows the distinguishing of two types of fortlet, front-entrance and rear-entrance. Fortlet known details are summarised in terms of stable, unstable and cliff situations. A new schedule of coastal sites shows that they were placed in relationship to the fort at Maryport south of Moricambe; MF 5 (Cardurnock) is not a milefortlet but should be regarded as a small terminal fort north of Moricambe. MF 22 (Brownrigg) is "long axis" 68 ft x 58 ft, has a central front entrance and "horseshoe" ditch. It was abandoned in AD 140. MF 16 Mawbray is at its correct measured position; its ditch was never dug. At T 16b (Mawbray Sandpit) a later tower than the Hadrianic one was confirmed. A possible part of a merlon cap was found. MF 20 (Low Mire) is "long axis" 60 ft x 48 ft, probably no ditch, with a rear entrance. Pottery of Wall Period IA with some 4th century sherds, an iron knife and other metal objects were found. B D
Performance of international prognostic indices in plasmablastic lymphoma: a comparative evaluation
Creators: name: Hertel, Nadine
name: Merz, Hartmut
name: Bernd, Heinz-Wolfram
name: Bernard, Veronica
name: Künstner, Axel
name: Busch, Hauke
name: Von Bubnoff, Nikolas
name: Feller, Alfred C.
name: Witte, Hanno M.
name: Gebauer, Niklas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Plasmablastic lymphoma
subject: IPI
subject: Prognosis
subject: Risk stratification
subject: DDC 610 / Medicine & health

description: Abstract Purpose Plasmablastic lymphoma (PBL) is a rare and aggressive B-cell malignancy with a heterogenous clinical and prognostic spectrum, determined by multiple factors, including age, HIV- and MYC-status. While there exist several validated scoring systems for diffuse large B-cell lymphoma, which incorporate basic clinical features (age, lactate dehydrogenase, sites of (extranodal) involvement, stage and performance), none of these have been systematically assessed in PBL. Methods We determined the (age-adjusted; aa)-International Prognostic Index (IPI), revised IPI (R-IPI), and National Comprehensive Cancer Network IPI (NCCN-IPI) in a comprehensive multi-center cohort (n = 78) of PBL patients. Further, all indices were comparatively investigated for model quality and concordance. Results Univariate analysis revealed significant prognostic capabilities for all indices, all of which identified a subgroup with favorable outcome. Discriminatory power between patients with less benign prognosis and especially refractory disease exhibited significant variability. Subsequently, stratified models for each risk score were compared employing corrected Akaike’s information criterion (cAIC) and Harrel’s concordance index (c-index). Here, the NCCN-IPI outperformed both IPI and R-IPI regarding c-index with ambiguous cAIC results, underlining its clinical utility and suggesting it for preferential use in clinical practice. Conclusion Our current observations support the use of the IPI and its enhanced derivatives in PBL patients. There is, however, a distinct requirement for novel prognostic tools to better delineate subgroups at risk for early relapse or refractory disease as well as late relapse. A comprehensive molecular characterization of a clinically annotated cohort of PBL patients is therefore urgently warranted.
Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms
Creators: name: Krause, Maren
name: Crauwels, Peter
name: Blanco-Pérez, Frank
name: Globisch, Martin
name: Wangorsch, Andrea
name: Henle, Thomas
name: Lidholm, Jonas
name: Van Zandbergen, Ger
name: Vieths, Stefan
name: Scheurer, Stephan
name: Toda, Masako
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: POLARIZATION
subject: RECEPTOR
subject: activation
subject: NONINTEGRIN
subject: BINDING
subject: LIGAND
subject: DDC 570 / Life sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular biology
subject: Dendritic cells
subject: Identification
subject: Proteins
subject: Protein binding
subject: Ligand binding (Biochemistry)
subject: Immunologie
subject: Molekularbiologie
subject: Dendritische Zelle
subject: Polarisierung
subject: Aktivierung
subject: Identifikation
subject: Proteine

description: Abstract Evidence has suggested that major peanut allergen Ara h 1 activates dendritic cells (DCs) via interaction with DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin), a C-type lectin receptor, and contributes to development of peanut allergy. Since macrophages, as well as DCs, play a crucial role in innate immunity, we investigated whether natural Ara h 1 (nAra h 1) activates two different subsets of macrophages, human monocyte derived macrophage type 1 (hMDM1: pro-inflammatory model) and type 2 (hMDM2: anti-inflammatory model). hMDM1 and hMDM2 predominantly produced pro-inflammatory cytokines (IL-6 and TNF-α) and an anti-inflammatory cytokine (IL-10) in response to nAra h 1, respectively. hMDM2 took up nAra h 1 and expressed DC-SIGN at higher levels than hMDM1. However, small interfering RNA knockdown of DC-SIGN did not suppress nAra h 1 uptake and nAra h 1-mediated cytokine production in hMDM2. Inhibitors of scavenger receptor class A type I (SR-AI) suppressed the response of hMDM2, but not of hMDM1, suggesting that SR-AI is a major receptor in hMDM2 for nAra h 1 recognition and internalization. nAra h 1 appears to exert stimulatory capacity on DC and macrophages via different receptors. This study advances our understanding how a major peanut allergen interacts with innate immunity.
Differential expression of microRNAs in the brains of mice subjected to increasing grade of mild traumatic brain injury
Creators: name: Raghavendar Chandran
name: Anuj Sharma
name: Bhomia, Manish
name: Nagaraja S. Balakathiresan
name: Knollmann-Ritschel, Barbara E.
name: Maheshwari, Radha K.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Objective: To investigate the effect of heterogeneity in mTBI on miRNA expression in mouse brain and to identify molecular pathways targeted by the modulated miRNAs. Methods: A weight drop device was used to induce four increasing grades of mTBI. MiRNA expression was evaluated using TaqMan rodent miRNA arrays. Bioinformatics analysis was done using the DIANA miRPath tool and Ingenuity Pathway Analysis software. Histology of brain sections was evaluated using H&E staining. Results: No histologic lesions were observed in the brains of injured mice; however, significant modulation in miRNA expression profile was observed. Global miRNA profiling indicated a trend of decrease in the number of modulated miRNAs from 24 hours to day 7 post-injury, except for the most severe grade of mTBI. Canonical pathways like calcium signalling, synaptic pathways and axon guidance pathway were the major targets of the modulated miRNAs. Network correlation analyses indicated an interaction between the modulated miRNAs and putative protein biomarkers of TBI. Conclusions: The data demonstrated that varying intensities of mTBI induced a differential miRNA expression profile in the brain post-injury. Pathways such as calcium and synaptic signalling were major targets of modulated miRNAs and may play a role in the pathophysiology of mTBI.
Risks and benefits of TIPS in HCC and other liver malignancies: a literature review
Creators: name: Fichtl, Anna
name: Seufferlein, Thomas
name: Zizer, Egon
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Transjugular intrahepatic portosystemic shunt (TIPS)
subject: Clinically significant portal Hypertension (CSPH)
subject: Hepatocellular carcinoma (HCC)
subject: Liver metastases
subject: Liver Cirrhosis
subject: DDC 610 / Medicine & health

description: Background Transjugular intrahepatic portosystemic shunt (TIPS) is a well-validated treatment option for clinically significant portal hypertension (CSPH) in the context of liver cirrhosis. Its high efficacy and safety in the management of treatment-refractory ascites and variceal bleeding have been extensively proven. Contraindications for TIPS include severe right heart failure, hepatic encephalopathy, and sepsis. However, the role of liver malignancy in TIPS is debatable. Mostly, primary liver malignancies such as hepatocellular carcinoma (HCC) emerge from advanced liver diseases. Coexisting portal hypertension in HCC often results in limited treatment options and a poor prognosis. Summary Previous studies have shown that TIPS implantation in patients with HCC is technically feasible and is usually not associated with major adverse events. Furthermore, TIPS may help in bridging the time to liver transplantation in early HCC and allow for locoregional treatment in advanced HCC. However, several studies suggest that seeding tumour cells to the lungs by TIPS placement might worsen the prognosis. Conclusions TIPS placement in patients with coexisting liver malignancy remains a case-by-case decision, and there is no profound evidence allowing general recommendations. This review aims to provide a state-of-the-art overview of the potential risks and benefits of TIPS placement in patients with liver malignancies.
Secure attachment predicts lower societal cost amongst severely antisocial adolescents
Creators: name: Bachmann, Christian J.
name: Humayun, Sajid
name: Stevens, Madeleine
name: O’Connor, Thomas G.
name: Scott, Stephen
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Antisocial behaviour
subject: Attachment
subject: Callous-unemotional traits
subject: Economic cost
subject: Youth
subject: DDC 150 / Psychology
subject: Psychology, Adolescent
subject: Antisocial personality disorder
subject: Fathers
subject: Parenting
subject: Object attachment
subject: Jugend
subject: Dissoziale Persönlichkeitsstörung
subject: Vater
subject: Kind

description: Background Social and economic costs associated with antisocial behaviour are well-established, but little is known about the potential costs savings/benefits of secure attachment in this high-risk group. We aimed to provide the first test of attachment quality as a distinct predictor of economic costs. Methods 111 adolescents (10–17 years of age, M = 15.0, SD = 1.6; 71% male) referred to young offender services due to high levels of antisocial behaviour were included. Costs were measured by detailed service-use interview, and attachment security to mother and father elicited through the Child Attachment Interview. The level of antisocial behaviour and callous-unemotional traits were assessed. Cost predictors were calculated using generalised linear models. Results Mean 12-months service costs were £5,368 (sd 5,769) per adolescent, with justice system and educational service costs being the main components. After adjusting for covariates, economic costs were predicted by attachment quality to fathers, with a difference of £2,655 per year between those with secure (£3,338) versus insecure attachment (£5,993); significant cost effects were not found for attachment quality to mothers. Higher levels of callous-unemotional traits, lower verbal IQ, higher levels of antisocial behaviour, and older age were also significant cost predictors. Conclusions Secure attachment to fathers is a predictor of reduced public cost in adolescents with severe antisocial behaviour. This novel finding for severely antisocial youth extends previous findings in less antisocial children and underscores the public health and policy benefits of good caregiving quality and the value of population-level dissemination of evidence-based interventions that improve caregiving quality.
The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA
Creators: name: Kaiser, Steffen
name: Jurkowski, Tomasz P.
name: Kellner, Stefanie
name: Schneider, Dirk
name: Jeltsch, Albert
name: Helm, Mark
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The amino acid sequence of Dnmt2 is very similar to the catalytic domains of bacterial and eukaryotic DNA-(cytosine 5)-methyltransferases, but it efficiently catalyzes tRNA methylation, while its DNA methyltransferase activity is the subject of controversial reports with rates varying between zero and very weak. By using composite nucleic acid molecules as substrates, we surprisingly found that DNA fragments, when presented as covalent DNA-RNA hybrids in the structural context of a tRNA, can be more efficiently methylated than the corresponding natural tRNA substrate. Furthermore, by stepwise development of tRNAAsp, we showed that this natural Dnmt2 substrate could be engineered to employ RNAs that act like guide RNAs in vitro. The 5’-half of tRNAAsp was able to efficiently guide methylation toward a single stranded tRNA fragment as would result from tRNA cleavage by tRNA specific nucleases. In a more artificial setting, a composite system of guide RNAs could ultimately be engineered to enable the enzyme to perform cytidine methylation on single stranded DNA in vitro.
Li–Yau inequalities for general non-local diffusion equations via reduction to the heat kernel
Creators: name: Weber, Frederic
name: Zacher, Rico
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: 35R11
subject: 35K08
subject: 60J27
subject: 39A12
subject: DDC 500 / Natural sciences & mathematics
subject: Inequalities (Mathematics)
subject: Ungleichung

description: We establish a reduction principle to derive Li–Yau inequalities for non-local diffusion problems in a very general framework, which covers both the discrete and continuous setting. Our approach is not based on curvature-dimension inequalities but on heat kernel representations of the solutions and consists in reducing the problem to the heat kernel. As an important application we solve a long-standing open problem by obtaining a Li–Yau inequality for positive solutions u to the fractional (in space) heat equation of the form (−Δ)β/2(logu)≤C/t, where β∈(0,2). We also show that this Li–Yau inequality allows to derive a Harnack inequality. We further illustrate our general result with an example in the discrete setting by proving a sharp Li–Yau inequality for diffusion on a complete graph.
A meta-analysis of fMRI studies on in-group and out-group categorisation differentiated by group membership and task
Creators: name: Sng, Kelly H.L.
Publisher: name: OSF Registries
Year: 2026
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences
subject: Arts and Humanities
subject: Neuroscience and Neurobiology
subject: Race, Ethnicity and Post-Colonial Studies
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Other Social and Behavioral Sciences

description: This systematic review primarily aims to clarify the neural basis of in-group and out-group categorisation. A secondary aim is to establish, through a meta-analysis, neural networks for in-group and out-group. We will examine only task functional magnetic resonance imaging (fMRI) studies conducted with healthy adults. With that, outcomes will additionally be discussed through differentiation by group membership and type of fMRI task.
Next generation Europe : a recovery plan for children, adolescents and their families
Creators: name: Fegert, Jörg M.
name: Kehoe, Laura A.
name: Çuhadaroglu Çetin, Fusun
name: Doyle, Maeve
name: Eliez, Stephan
name: Hebebrand, Johannes
name: Hillegers, Manon
name: Kotsis, Konstantinos
name: Kiss, Eniko
name: Pejovic‐Milovancevic, Milica
name: Räberg Christensen, Anne-Marie
name: Raynaud, Jean Philippe
name: Anagnostopoulos, Dimitris
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: DDC 150 / Psychology
subject: Covid-19 (Pandemic); Social aspects
subject: COVID-19
subject: Child welfare
subject: Pandemics
subject: Psychology, Child
subject: Psychology, Adolescent
subject: Kind
subject: Jugend
subject: COVID-19
subject: Pandemie
subject: Kindeswohl
subject: Menschenrecht

description: The youth of today—our most precious resource—are finally getting the attention they deserve. The impact of the COVID-19 pandemic, including the toll exerted on their mental health had been overlooked during the early months of the pandemic. In the first lockdown, the needs of children and adolescents and their families were largely ignored apart from the child and adolescent psychiatrists all over Europe who worked tirelessly on their behalf. The lives of our young people were severely restricted and for many, this complex situation was incomprehensible. The protection of these children’s rights and their welfare have finally come sharply into focus. But how can we ensure that this focus will continue? How can the neglect of children, adolescents and their families be remedied? What should the future hold for the next generation Europe after the acute phase of the pandemic? The use of terms such as “lost generation” or “generation Corona” should be discouraged as this could foster a belief that they cannot be helped and that the neglect that they have suffered is irreparable. This position is neither legally, socially nor ethically justifiable. The constant calls by UNICEF and other organizations like ESCAP to respect children’s rights is not an aspirational one. These organizations ensure the fundamental rights of children to be heard and to have their situation considered. The pandemic is shedding light on this fact like never before. The protection of minors must therefore be articulated as a state objective with constitutional status.
Quantitative comparison of different approaches for reconstructing the carbon-binder domain from tomographic image data of cathodes in lithium-ion batteries and its iInfluence on electrochemical properties
Creators: name: Prifling, Benedikt
name: Neumann, Matthias
name: Hein, Simon
name: Danner, Timo
name: Heider, Emanuel
name: Hoffmann, Alice
name: Rieder, Philipp
name: Hilger, André
name: Osenberg, Markus
name: Manke, Ingo
name: Wohlfahrt-Mehrens, Margret
name: Latz, Arnulf
name: Schmidt, Volker
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: 3D imaging
subject: carbon-binder domain
subject: electrochemical performance
subject: microstructures
subject: modeling and simulation
subject: structuring concept for lithium-ion batteries
subject: Three-dimensional imaging
subject: Image segmentation
subject: Dreidimensionales Bild
subject: Bildsegmentierung
subject: Mikrostruktur
subject: Lithium-Ionen-Akkumulator

description: It is well known that the spatial distribution of the carbon-binder domain (CBD) offers a large potential to further optimize lithium-ion batteries. However, it is challenging to reconstruct the CBD from tomographic image data obtained by synchrotron tomography. Herein, several approaches are considered to segment 3D image data of two different cathodes into three phases, namely, active material, CBD, and pores. More precisely, it is focused on global thresholding, a local closing approach based on energy-dispersive X-ray spectroscopy data, a k-means clustering method, and a procedure based on a neural network that has been trained by correlative microscopy, i.e., based on data gained by synchrotron tomography and focused ion beam scanning electron microscopy data representing the same electrode. The impact of the considered segmentation approaches on morphological characteristics as well as on the resulting performance by spatially resolved transport simulations is quantified. Furthermore, experimentally determined electrochemical properties are used to identify an appropriate range for the effective transport parameter of the CBD. The developed methodology is applied to two differently manufactured cathodes, namely, an ultrathick unstructured cathode and a two-layer cathode with varying CBD content in both layers. This comparison elucidates the impact of a specific structuring concept on the 3D microstructure of cathodes.
Evaluation of protein–ligand affinity prediction using steered molecular dynamics simulations
Creators: name: Okimoto, Noriaki
name: Suenaga, Atsushi
name: Taiji, Makoto
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In computational drug design, ranking a series of compound analogs in a manner that is consistent with experimental affinities remains a challenge. In this study, we evaluated the prediction of protein–ligand binding affinities using steered molecular dynamics simulations. First, we investigated the appropriate conditions for accurate predictions in these simulations. A conic harmonic restraint was applied to the system for efficient sampling of work values on the ligand unbinding pathway. We found that pulling velocity significantly influenced affinity predictions, but that the number of collectable trajectories was less influential. We identified the appropriate pulling velocity and collectable trajectories for binding affinity predictions as 1.25 Å/ns and 100, respectively, and these parameters were used to evaluate three target proteins (FK506 binding protein, trypsin, and cyclin-dependent kinase 2). For these proteins using our parameters, the accuracy of affinity prediction was higher and more stable when Jarzynski’s equality was employed compared with the second-order cumulant expansion equation of Jarzynski’s equality. Our results showed that steered molecular dynamics simulations are effective for predicting the rank order of ligands; thus, they are a potential tool for compound selection in hit-to-lead and lead optimization processes.
title: Μελέτη της χρήσης φασματοσκοπίας υπερύθρου μετασχηματισμού Fourier (FT-IR) στο διαχωρισμό οίνων από περισσότερες από μια ποικιλίες
title: Feasibility study on the use of FT-IR for the discrimination of wine blends
titleType: AlternativeTitle
Creators: name: Στέφου, Άννα
name: Γεωργουλάκη, Άννα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Μετασχηματισμός Fourier
Ξινόμαυρο
Αγιωργίτικο
Υπέρυθρη φασματοσκοπία (IR)
Ταξινόμηση οίνων

description: Η ποικιλία και η προέλευση ενός οίνου αποτελούν παράγοντες που καθορίζουν την ποιότητά του, καθώς και την τιμή στην οποία θα προωθηθεί στο εμπόριο και την αγορά. Για το λόγο αυτό κρίνεται αναγκαία η ταξινόμηση των οίνων με βάση τα παραπάνω χαρακτηριστικά με στόχευση στην αυθεντικότητα. Τα τελευταία χρόνια η ανάλυση της σύστασης των ελληνικών ποικιλιών έχει αποκτήσει μεγάλο ενδιαφέρον αφού γίνεται μια προσπάθεια «χαρακτηρισμού» όλων των καλλιεργήσιμων ποικιλιών παγκοσμίως. Χρησιμοποιώντας τις κατάλληλες αναλυτικές τεχνικές, για την ταξινόμηση οίνων από διαφορετικές ποικιλίες ή/και περιοχές μπορεί γίνει διάκριση μεταξύ των ποικιλιών και έλεγχος της αυθεντικότητας. Στην παρούσα πτυχιακή μελέτη αξιολογήθηκε η καταλληλότητα της φασματοσκοπίας υπερύθρου μετασχηματισμού Fourier (FTIR), η οποία έχει χρησιμοποιηθεί με επιτυχία στην ταξινόμηση οίνων με βάση τον τόπο παραγωγής τους, για την ανίχνευση της νοθείας. Πιο συγκεκριμένα μελετήθηκαν οίνοι από τις ποικιλίες Ξινόμαυρο, Αγιωργίτικο και μίγματα αυτών. Το συμπέρασμα που προέκυψε είναι ότι με την χρήση της υπέρυθρης φασματοσκοπίας (IR) μπορεί να επιτευχθεί διαχωρισμός των μονοποικιλιακών δειγμάτων από τα μίγματα. Η μέθοδος παρουσιάζει ενδιαφέρον λόγω της ευκολίας λήψης φασμάτων και θα μπορούσε να χρησιμοποιηθεί τόσο για να γίνει διάκριση μεταξύ των ποικιλιών όσο και περιπτώσεις που είναι απαραίτητος ο έλεγχος της αυθεντικότητας.
title: Compétences en littératie, numératie et résolution de problèmes des adultes en Suisse
title: Premiers résultats de l'enquête PIAAC 2022/2023
titleType: Subtitle
Creators: name: Office fédéral de la statistique
Publisher: name: Office fédéral de la statistique
publisherIdentifier: https://ror.org/027h8t796
publisherIdentifierScheme: ROR
Year: 2024

description: Le Programme international pour l'évaluation des compétences des adultes (PIAAC, Programme for the International Assessment of Adult Competencies) est une enquête internationale menée tous les dix ans par l'Organisation de coopération et de développement économiques (OCDE) afin de mesurer les compétences des adultes. L'enquête 2022/2023 été réalisée dans 31 États membres et pays partenaires de l'OCDE parmi lesquels - pour la première fois - la Suisse. La présente enquête, en plus de mesurer les compétences en lecture et en mathématiques déjà évaluées lors du premier cycle, apprécie également la résolution adaptative de problèmes. Le rapport compare les premiers résultats du PIAAC pour la Suisse sur le plan international, puis au niveau national, entre les régions linguistiques et entre les grandes régions. Il vise à saisir les niveaux de compétences de la population en fonction de caractéristiques sociodémographiques telles que le sexe, l'âge, le niveau de formation, le statut sur le marché du travail et le profil migratoire. Le rapport décrit en outre de façon détaillée les groupes ayant de faibles compétences.
title: Kosten und Finanzierung des Verkehrs 2021
Creators: name: Bundesamt für Statistik
Publisher: name: Bundesamt für Statistik
publisherIdentifier: https://ror.org/027h8t796
publisherIdentifierScheme: ROR
Year: 2024

description: Wie hoch sind die durch den Verkehr in der Schweiz verursachten Kosten, wie sind sie entstanden und wer hat sie übernommen? Die vorliegende Publikation beantwortet diese und weitere Fragen für den motorisierten Strassen- und Schienenverkehr, den Langsamverkehr, die Luftfahrt sowie für die Schifffahrt. Berücksichtigt werden nicht nur monetäre Ausgaben wie etwa für Fahrzeuge und Infrastrukturen, sondern auch immaterielle Kosten, beispielsweise verkehrsbedingte Unfall-, Umwelt- oder Gesundheitsschäden.
Dynamics in treatment response and disease progression of metastatic colorectal cancer (mCRC) patients with focus on BRAF status and primary tumor location: analysis of untreated RAS-wild-type mCRC patients receiving FOLFOXIRI either with or without panitumumab in the VOLFI trial (AIO KRK0109)
Creators: name: Kurreck, A.
name: Geissler, M.
name: Martens, U. M.
name: Riera-Knorrenschild, J.
name: Greeve, J.
name: Florschuetz, A.
name: Wessendorf, S.
name: Ettrich, T.
name: Kanzler, S.
name: Noerenberg, D.
name: Seidensticker, M.
name: Held, S.
name: Buechner-Steudel, P.
name: Atzpodien, J.
name: Heinemann, V
name: Stintzing, S.
name: Seufferlein, Thomas
name: Tannapfel, A.
name: Reinacher-Schick, A. C.
name: Modest, D. P.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Metastatic colorectal cancer
subject: Disease dynamics
subject: Depth of response
subject: Early tumor shrinkage
subject: BRAF
subject: Primary tumor site
subject: Combination chemotherapy
subject: FOLFIRI PLUS BEVACIZUMAB
subject: 1ST-LINE TREATMENT
subject: OPEN-LABEL
subject: SHRINKAGE ETS
subject: COLON-CANCER
subject: CETUXIMAB
subject: PHASE-3
subject: FIRE-3
subject: CHEMOTHERAPY
subject: INSTABILITY
subject: DDC 610 / Medicine & health

description: Abstract Purpose In mCRC, disease dynamics may play a critical role in the understanding of long-term outcome. We evaluated depth of response (DpR), time to DpR, and post-DpR survival as relevant endpoints. Methods We analyzed DpR by central review of computer tomography images (change from baseline to smallest tumor diameter), early tumor shrinkage (≥ 20% reduction in tumor diameter at first reassessment), time to DpR (study randomization to DpR-image), post-DpR progression-free survival (pPFS = DpR-image to tumor progression or death), and post-DpR overall survival (pOS = DpR-image to death) with special focus on BRAF status in 66 patients and primary tumor site in 86 patients treated within the VOLFI-trial, respectively. Results BRAF wild-type (BRAF-WT) compared to BRAF mutant (BRAF-MT) patients had greater DpR (− 57.6% vs. − 40.8%, p = 0.013) with a comparable time to DpR [4.0 (95% CI 3.1–4.4) vs. 3.9 (95% CI 2.5–5.5) months; p = 0.8852]. pPFS was 6.5 (95% CI 4.9–8.0) versus 2.6 (95% CI 1.2–4.0) months in favor of BRAF-WT patients (HR 0.24 (95% CI 0.11–0.53); p < 0.001). This transferred into a significant difference in pOS [33.6 (95% CI 26.0–41.3) vs. 5.4 (95% CI 5.0–5.9) months; HR 0.27 (95% CI 0.13–0.55); p < 0.001]. Similar observations were made for patients stratified for primary tumor site. Conclusions BRAF-MT patients derive a less profound treatment response compared to BRAF-WT patients. The difference in outcome according to BRAF status is evident after achievement of DpR with BRAF-MT patients hardly deriving any further disease control beyond DpR. Our observations hint towards an aggressive tumor evolution in BRAF-MT tumors, which may already be molecularly detectable at the time of DpR.
title: Competenze in lettura, matematica elementare e risoluzione di problemi degli adulti in Svizzera
title: Primi risultati dell'indagine PIAAC 2022/2023
titleType: Subtitle
Creators: name: Ufficio federale di statistica
Publisher: name: Ufficio federale di statistica
publisherIdentifier: https://ror.org/027h8t796
publisherIdentifierScheme: ROR
Year: 2024

description: Il Programme for the International Assessment of Adult Competencies (PIAAC), programma internazionale finalizzato alla valutazione delle competenze della popolazione adulta, è un’indagine internazionale condotta ogni dieci anni dall’Organizzazione per la cooperazione e lo sviluppo economico (OCSE) per misurare le competenze cognitive degli adulti. Nel 2022/2023 vi hanno partecipato 31 Stati membri dell’OCSE e Paesi partner, tra cui, per la prima volta, la Svizzera. Come era accaduto nel primo ciclo di rilevazione, sono state misurate le competenze in lettura e matematica elementare, oltre che nella risoluzione adattiva di problemi. Il rapporto presenta i primi risultati del PIAAC per la Svizzera nel confronto internazionale, così come per Grandi Regioni e regioni linguistiche. Esamina i livelli di competenza della popolazione in base a caratteristiche sociodemografiche come il sesso, l’età, il livello di formazione, la condizione lavorativa e il profilo migratorio. I gruppi con basse competenze sono descritti in modo più dettagliato.
Pheromone communication among sexes of the garden cross spider Araneus diadematus
Creators: name: Fischer, Andreas
name: Schulz, Stefan
name: Ayasse, Manfred
name: Uhl, Gabriele
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Sex pheromone
subject: Female-female-interaction
subject: Autodetection
subject: Olfaction
subject: DDC 590 / Animals (Zoology)
subject: Insect sex attractants
subject: Electrophysiology
subject: Spider
subject: Smell
subject: Pheromonfalle
subject: Elektrophysiologie

description: Chemical communication plays a fundamental role in many aspects of an animal’s life from assessing habitat quality to finding mating partners. Behavioural observations show that chemical communication likewise plays an important role in spiders, but the contexts and the substances involved are little explored. Here, we investigate the chemical communication in the garden cross spider Araneus diadematus (Clerck, 1757) between and within the sexes. Using choice trials, we demonstrate that males are attracted to odours of adult females, but not to those of subadult females. Our data further suggest that adult females avoid odours of conspecific adult females, possibly in order to reduce reproductive competition with other females. Cuticle and silk extracts as well as headspace samples of subadult and adult virgin females were analysed via GC–MS. Available candidate compounds for the female sex pheromone were tested via electroantennography on palps (electropalpography) of adult virgin females and on females in behavioural trials. We propose sulcatone (6-methyl-5-hepten-2-one) as a candidate substance for the female volatile pheromone and several long-chained alkanes and alcohols as candidates for contact pheromones. Apart from demonstrating that attraction of males to females depends on the latter’s developmental stage, our study suggests that pheromones can also play an important role between females, an aspect that requires further attention.
Pretrained blastocyst detection, clinical pregnancy prediction, live birth prediction models
Creators: name: Yu, Lu
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 321502
subject: Obstetrics and gynaecology
classificationCode: 460304
subject: Computer vision

description: Blastocysts detection, clinical pregnancy prediction, live birth prediction models (keras) pretrained on post-warmed blastocysts static images.
Excavations at Tullie House, Carlisle 1954-56.
Creators: name: Hogg, Robert
name: Gillam, John Pearson
name: Jarrett, Michael G
name: Edwards, B J N
Publisher: name: Archaeology Data Service
Year: 2008

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 64, 14-62