cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
New Langevin and Gradient Thermostats for Rigid Body Dynamics
Creators: name: Davidchack, R. L.
name: Ouldridge, T. E.
name: Tretyakov, M. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Numerical Analysis (math.NA)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 65C30, 60H35, 60H10

description: We introduce two new thermostats, one of Langevin type and one of gradient (Brownian) type, for rigid body dynamics. We formulate rotation using the quaternion representation of angular coordinates; both thermostats preserve the unit length of quaternions. The Langevin thermostat also ensures that the conjugate angular momenta stay within the tangent space of the quaternion coordinates, as required by the Hamiltonian dynamics of rigid bodies. We have constructed three geometric numerical integrators for the Langevin thermostat and one for the gradient thermostat. The numerical integrators reflect key properties of the thermostats themselves. Namely, they all preserve the unit length of quaternions, automatically, without the need of a projection onto the unit sphere. The Langevin integrators also ensure that the angular momenta remain within the tangent space of the quaternion coordinates. The Langevin integrators are quasi-symplectic and of weak order two. The numerical method for the gradient thermostat is of weak order one. Its construction exploits ideas of Lie-group type integrators for differential equations on manifolds. We numerically compare the discretization errors of the Langevin integrators, as well as the efficiency of the gradient integrator compared to the Langevin ones when used in the simulation of rigid TIP4P water model with smoothly truncated electrostatic interactions. We observe that the gradient integrator is computationally less efficient than the Langevin integrators. We also compare the relative accuracy of the Langevin integrators in evaluating various static quantities and give recommendations as to the choice of an appropriate integrator.
description: 16 pages, 4 figures
Betrachtung der Passion Jesu Christi (Fragment)
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1350

description: Öffentliche Bibliothek der Universität Basel
description: Mittelniederländisch
description: Aus der Mittelalterlichen Sammlung Wilhelm Wackernagels, angelegt ab 1856, eingeklebt in Album 2 (N I 2), S. 95; herausgelöst und konservatorisch neu verpackt 2015/2016. Bei Heyne (ca. 1869-1883) nicht verzeichnet. Frühere Signatur recto: "Fragm. II, 95". Das Fragment war in den hinteren Innendeckel von UBH Aleph E IV 21a (David Joris, T Wonder-Boeck, Deventer 1544) geklebt, verso Verweis auf den Trägerband.
description: Verzeichnung=Description=Inventaire Okt. 2021 HAN-Katalogisierungsregeln Minimalaufnahme nach: Handschriftencensus Studer
description: Verzeichnung=Description=Inventaire Jan. 2023 HAN-Katalogisierungsregeln Normalaufnahme nach Binz, 1936; mit Ergänzungen Flury
description: Digitalisierung=Digitization=Numérisation Dez. 2023 TIFF
description: Erschliessungsniveau Normalniveau
Joint queue length distribution of multi-class, single server queues with preemptive priorities
Creators: name: Sleptchenko, Andrei
name: Selen, Jori
name: Adan, Ivo
name: van Houtum, Geert-Jan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K25, 90B25

description: In this paper we analyze an $M/M/1$ queueing system with an arbitrary number of customer classes, with class-dependent exponential service rates and preemptive priorities between classes. The queuing system can be described by a multi-dimensional Markov process, where the coordinates keep track of the number of customers of each class in the system. Based on matrix-analytic techniques and probabilistic arguments we develop a recursive method for the exact determination of the equilibrium joint queue length distribution. The method is applied to a spare parts logistics problem to illustrate the effect of setting repair priorities on the performance of the system. We conclude by briefly indicating how the method can be extended to an $M/M/1$ queueing system with non-preemptive priorities between customer classes.
description: 15 pages, 5 figures -- version 3 incorporates minor textual changes and fixes a few math typos
Anticoagulant heparan sulfate: structural specificity and biosynthesis
Creators: name: Liu, Jian
name: Pedersen, Lars C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Heparan sulfate (HS) is present on the surface of endothelial and surrounding tissues in large quantities. It plays important roles in regulating numerous functions of the blood vessel wall, including blood coagulation, inflammation response and cell differentiation. HS is a highly sulfated polysaccharide containing glucosamine and glucuronic/iduronic acid repeating disaccharide units. The unique sulfated saccharide sequences of HS determine its specific functions. Heparin, an analogue of heparan sulfate, is the most commonly used anticoagulant drug. Because of its wide range of biological functions, HS has become an interesting molecule to biochemists, medicinal chemists and developmental biologists. Here, we summarize recent progress towards understanding the interaction between heparan sulfate and blood coagulating factors, the biosynthesis of anticoagulant heparan sulfate and the mechanism of action of heparan sulfate biosynthetic enzymes. Further, knowledge of the biosynthesis of HS facilitates the development of novel enzymatic approaches to synthesize HS from bacterial capsular polysaccharides and to produce polysaccharide end products with high specificity for the biological target. These advancements provide the foundation for the development of polysaccharide-based therapeutic agents.
Deep Captioning with Multimodal Recurrent Neural Networks (m-RNN)
Creators: name: Mao, Junhua
name: Xu, Wei
name: Yang, Yi
name: Wang, Jiang
name: Huang, Zhiheng
name: Yuille, Alan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: I.2.6; I.2.7; I.2.10

description: In this paper, we present a multimodal Recurrent Neural Network (m-RNN) model for generating novel image captions. It directly models the probability distribution of generating a word given previous words and an image. Image captions are generated by sampling from this distribution. The model consists of two sub-networks: a deep recurrent neural network for sentences and a deep convolutional network for images. These two sub-networks interact with each other in a multimodal layer to form the whole m-RNN model. The effectiveness of our model is validated on four benchmark datasets (IAPR TC-12, Flickr 8K, Flickr 30K and MS COCO). Our model outperforms the state-of-the-art methods. In addition, we apply the m-RNN model to retrieval tasks for retrieving images or sentences, and achieves significant performance improvement over the state-of-the-art methods which directly optimize the ranking objective function for retrieval. The project page of this work is: www.stat.ucla.edu/~junhua.mao/m-RNN.html .
description: Add a simple strategy to boost the performance of image captioning task significantly. More details are shown in Section 8 of the paper. The code and related data are available at https://github.com/mjhucla/mRNN-CR ;. arXiv admin note: substantial text overlap with arXiv:1410.1090
Additional file 1 of Acceptability of the routine use and collection of a generic patient reported outcome measure from the perspective of healthcare staff: a qualitative study
Creators: name: Snowdon, David A
name: Srikanth, Velandai
name: Beare, Richard
name: Noeske, Kate E
name: Le, Elizabeth
name: O’Bree, Bridget
name: Andrew, Nadine E
Publisher: name: figshare
Year: 2023
Subjects: Space Science
Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1
Harmonic functions with finite $p$-energy on lamplighter graphs are constant
Creators: name: Gournay, Antoine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The aim of this note is to show that lamplighter graphs where the space graph is infinite and at most two-ended and the lamp graph is at most two-ended do not admit harmonic functions with gradients in $\ell^p$ (\ie finite $p$-energy) for any $p\in [1,\infty[$ except constants (and, equivalently, that their reduced $\ell^p$ cohomology is trivial in degree one). Using similar arguments, it is also shown that many direct products of graphs (including all direct products of Cayley graphs) do not admit non-constant harmonic function with gradient in $\ell^p$. The proof relies on a theorem of Thomassen on spanning lines in squares of graphs.
description: 6 pages
Pyrosequence analyses of bacterial communities during simulated in situ bioremediation of polycyclic aromatic hydrocarbon-contaminated soil
Creators: name: Richardson, Stephen D.
name: Jones, Maiysha D.
name: Singleton, David R.
name: Aitken, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Barcoded amplicon pyrosequencing was used to generate libraries of partial 16S rRNA genes from two columns designed to simulate in situ bioremediation of polycyclic aromatic hydrocarbons (PAHs) in weathered, contaminated soil. Both columns received a continuous flow of artificial groundwater but one of the columns additionally tested the impact of biostimulation with oxygen and inorganic nutrients on indigenous soil bacterial communities. The penetration of oxygen to previously anoxic regions of the columns resulted in the most significant community changes. PAH-degrading bacteria previously determined by stable-isotope probing (SIP) of the untreated soil generally responded negatively to the treatment conditions, with only members of the Acidovorax and a group of uncharacterized PAH-degrading Gammaproteobacteria maintaining a significant presence in the columns. Additional groups of sequences associated with the Betaproteobacterial family Rhodocyclaceae (including those associated with PAH degradation in other soils), and the Thiobacillus, Thermomonas, and Bradyrhizobium genera were also present in high abundance in the biostimulated column. Similar community responses were previously observed during biostimulated ex situ treatment of the same soil in aerobic, slurry-phase bioreactors. While the low relative abundance of many SIP-determined groups in the column libraries may be a reflection of the slow removal of PAHs in that system, the similar response of known PAH-degraders in a higher-rate bioreactor system suggests that alternative PAH-degrading bacteria, unidentified by SIP of the untreated soil, may also be enriched in engineered systems.
A plethora of generalised solitary gravity-capillary water waves
Creators: name: Clamond, Didier
name: Dutykh, Denys
name: Duran, Angel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Numerical Analysis (math.NA)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 76B45, 76B25 (primary), 76B15 (secondary)

description: The present study describes, first, an efficient algorithm for computing capillary-gravity solitary waves solutions of the irrotational Euler equations with a free surface and, second, provides numerical evidences of the existence of an infinite number of generalised solitary waves (solitary waves with undamped oscillatory wings). Using conformal mapping, the unknown fluid domain, which is to be determined, is mapped into a uniform strip of the complex plane. In the transformed domain, a Babenko-like equation is then derived and solved numerically.
description: 20 pages, 7 figures, 45 references. Other author's papers can be downloaded at http://www.denys-dutykh.com/
Re-examining Frensham points: unusual Mesolithic curved flints from south-west Surrey
Creators: name: Goode, Ian
Publisher: name: Archaeology Data Service
Year: 2023

description: Surrey Archaeological Collections, 105, 53-64
description: During a study of Mesolithic flintwork in the Museum of Farnham, the newly-added collection by R G V Venables was also examined, together with its accompanying documents. The Venables collection includes a number of microliths, mostly from around Frensham, which had been described in papers published by W F Rankine in the 1940s, but have not been studied in detail since. The subject microliths have a unique curved shape and appear to be found almost exclusively in the local area. They had been dismissed as being forgeries, a view that persisted for several decades, so the main aim of the work described here was to tackle the problem of their authenticity, both of antiquity and location.
Service scheduling and vehicle routing problem to minimise the risk of missing appointments
Creators: name: Chenlu Ji
Publisher: name: Figshare
Year: 2019
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business

description: This research studies a workforce scheduling and vehicle routing problem where technicians drive a vehicle to customer locations to perform service tasks. The service times and travel times are subject to stochastic events. There is an agreed time window for starting each service task. The risk of missing the time window for a task is defined as the probability that the technician assigned to the task arrives at the customer site later than the time window. The problem is to generate a schedule that minimises the maximum of risks and the sum of risks of all the tasks considering the effect of skill levels and task priorities. A new approach is taken to build schedules that minimise the risks of missing appointments as well as the risks of technicians not being able to complete their daily tours on time.We first analyse the probability distribution of the arrival time to any customer location considering the distributions of activities prior to this arrival. Based on the analysis, an efficient estimation method for calculating the risks is proposed, which is highly accurate and this is verified by comparing the results of the estimation method with a numerical integral method.We then develop three new workforce scheduling and vehicle routing models that minimise the risks with different considerations such as an identical standard deviation of the duration for all uncertain tasks in the linear risk minimisation model, and task priorities in the priority task risk minimisation model. A simulated annealing algorithm is implemented for solving the models at the start of the day and for re-optimisation during the day. Computational experiments are carried out to compare the results of the risk minimisation models with those of the traditional travel cost model. The performance is measured using risks and robustness. Simulation is used to compare the numbers of missed appointments and test the effect of re-optimisation.The results of the experiments demonstrate that the new models significantly reduce the risks and generate schedules with more contingency time allowances. Simulation results also show that re-optimisation reduces the number of missed appointments significantly. The risk calculation methods and risk minimisation algorithm are applied to a real-world problem in the telecommunication sector.
MPEC 2024-R277 : 2024 RC13
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RC13

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Sources and resources: importance of nutrients, resource allocation, and ecology in microalgal cultivation for lipid accumulation
Creators: name: Characklis, Gregory W.
name: Peyton, Brent M.
name: Corredor, Luisa
name: Lohman, Egan J.
name: Hise, Adam
name: Gardner, Rob D.
name: Bell, Tisza
name: Gerlach, Robin
name: Moll, Karen
name: Fields, Matthew W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Regardless of current market conditions and availability of conventional petroleum sources, alternatives are needed to circumvent future economic and environmental impacts from continued exploration and harvesting of conventional hydrocarbons. Diatoms and green algae (microalgae) are eukaryotic photoautotrophs that can utilize inorganic carbon (e.g., CO2) as a carbon source and sunlight as an energy source, and many microalgae can store carbon and energy in the form of neutral lipids. In addition to accumulating useful precursors for biofuels and chemical feed stocks, the use of autotrophic microorganisms can further contribute to reduced CO2 emissions through utilization of atmospheric CO2. Because of the inherent connection between carbon, nitrogen, and phosphorus in biological systems, macronutrient deprivation has been proven to significantly enhance lipid accumulation in different diatom and algae species. However, much work is needed to understand the link between carbon, nitrogen, and phosphorus in controlling resource allocation at different levels of biological resolution (cellular versus ecological). An improved understanding of the relationship between the effects of N, P, and micronutrient availability on carbon resource allocation (cell growth versus lipid storage) in microalgae is needed in conjunction with life cycle analysis. This mini-review will briefly discuss the current literature on the use of nutrient deprivation and other conditions to control and optimize microalgal growth in the context of cell and lipid accumulation for scale-up processes.
A scoping review of international virtual knowledge exchanges for healthcare professionals
Creators: name: Bridgwood, Bernadeta
name: Woolley, Kate
name: Poppleton, Aaron
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: International knowledge exchanges within healthcare have historically been a popular method to provide exposure to practice in other national and international healthcare settings. As the COVID-19 pandemic forced many countries into lockdowns, knowledge exchanges in healthcare were forced into a period of suspension. This provided an opportunity to consider alternative methods of delivery. This scoping review explores virtual knowledge exchanges in healthcare professional education, including their format and related outcomes. Thirty-four virtual knowledge exchanges were identified. These demonstrated viability and subjective participant satisfaction. Virtual methods removed barriers of time, distance and finance associated with traditional exchanges, while still facilitating engagement with other international healthcare colleagues. However these exchanges were heterogeneous in their aims, structure and theoretical underpinnings. An understanding of educational outcomes and their measurement was not always obvious. Applying an overlay of robust pedagogical theory would strengthen and provide structure to the clearly well valued activity of international exchange.
Opposition to Refugee Resettlement: Comparative Perspectives
Creators: name: Clayton, Katherine
name: Ferwerda, Jeremy
name: Horiuchi, Yusaku
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: The purpose of this study is to evaluate global attitudes toward refugee resettlement via online public opinion surveys conducted in 10 countries: Australia, Canada, France, Germany, the Netherlands, New Zealand, Norway, Sweden, the United Kingdom, and the United States. In previous research conducted primarily in the United States (https://osf.io/wve96; https://osf.io/vb2uz), we have found consistent evidence of higher support for refugee resettlement at the international level than the national level, and higher support for refugee resettlement at the national level than the local level—evidence of not-in-my-backyard (NIMBY) attitudes toward refugee resettlement. These patterns were largely robust across demographic and attitudinal subgroups. In this study, we examine NIMBY attitudes further, examining how they vary across a wider array of countries, as well as across additional demographic and attitudinal subgroups. By examining how attitudes towards refugees are correlated with the strength of NIMBYism, we also hope to shed light on the theoretical mechanism driving NIMBY attitudes.
An intervention for multiethnic obese parents and overweight children
Creators: name: Berry, Diane
name: Savoye, Mary
name: Grey, Margaret
name: Melkus, Gail
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The purpose of this pilot study was to determine the effects of the addition of coping skills training for obese multiethnic parents whose overweight children were attending a weight management program. At 6 months, parents in the experimental group had significantly lower body mass index (BMI) and body fat percentage (BFP), and higher numbers of pedometer steps compared to the control group. Parents also demonstrated significant improvement in interpersonal relationships, behavior control, and stress management compared to the control group. Children in the experimental group demonstrated trends toward decreased BMI and BFP and increased pedometer steps.
Death shall not part us: a potential case of the curation of human remains from Roman Ewell
Creators: name: Green, Ellen
Publisher: name: Archaeology Data Service
Year: 2023

description: Surrey Archaeological Collections, 105, 65-72
description: This article examines evidence for the curation of human remains during the 1st century AD in Ewell. Taphonomic analysis of human remains recovered from the structured deposit on the Nescot College former animal husbandry site revealed that eleven bones appeared to have a 'polished' surface, indicating a different post-mortem treatment to the rest of the assemblage. This paper evaluates the possible taphonomic causes of this effect to establish the likelihood of curation of the remains during the early Roman period. The polished state of a selection of the bones indicates that they were subject to different taphonomic pathways, indicating they were probably curated for a period before redeposition. The idea of curating parts of the body after death, while non-normative in Roman culture, is well attested in the British Iron Age. The Ewell example, therefore, has the potential to illustrate the continuity of belief and ritual immediately after the Roman conquest, as well as widening understanding of non-normative mortuary behaviours in Roman Britain.
Towards modulated feeding for the efficient and phenotypically controlled expansion of articular chondrocytes
Creators: name: Curry, Dan
Publisher: name: Figshare
Year: 2019
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: Cell culture of chondrocytes, either in an experimental or industrial setting, typically rely on an invariant feeding strategy. The contribution of each component of the total expansion regime to the behaviour of the cells been expanded are not fully understood. It can be argued that to fully realise the potential of cell-based therapies, the exact contribution of the various expansion parameters to growth rate, metabolic behaviour and cell phenotype need to be intimately understood.	The studies in this thesis aim to better inform the nutritional aspects of future cell manufacturing strategy by; uncovering the contribution of critical culture parameters to growth rate and phenotype, understanding the relationship of any interactions that may exist between components and how these components may influence the culture as a function of time.	Results from the various studies demonstrated that an isolated subpopulation of chondrocytes can be sustained under serum-free conditions that promote SOX-9 transcript expression while returning growth rates similar to that found using serum-based medium. The contribution of the medium components, seed density and adhesion protein concentration to growth rate, metabolic behaviour and SOX-9,6 & 5 transcript expression were quantified using a statistically designed experiment. Two factors from the experiment, EGF and FGF-2, were taken forward and their effects on growth rate and gene expression as a function of time were investigated. The findings revealed that the exact timing of the introduction of the proteins into the culture medium had a marked impact on cell growth and gene expression.
“It's a touchy subject”: Latino adolescent sexual risk behaviors in the school context
Creators: name: Sandelowski, Margarete
name: McQuiston, Chris
name: Larson, Kim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Adverse sexual health outcomes remain disproportionately high for Latino adolescents. To examine sexual risk behaviors in Latino adolescents, we conducted in-depth interviews with 18 Latino parents and 13 school staff members and carried out one year of fieldwork in the school and community. “It’s a touchy subject [sex] here” exemplified the reluctance of addressing sexual risk behaviors. Community and systems-level strategies are recommended.
A carbon nanotube field emission multipixel x-ray array source for microradiotherapy application
Creators: name: Chang, Sha
name: Zhou, Otto
name: Wang, Sigen
name: Calderon, Xiomara
name: Schreiber, Eric C.
name: Peng, Rui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The authors report a carbon nanotube (CNT) field emission multipixel x-ray array source for microradiotherapy for cancer research. The developed multipixel x-ray array source has 50 individually controllable pixels and it has several distinct advantages over other irradiation source including high-temporal resolution (millisecond level), the ability to electronically shape the form, and intensity distribution of the radiation fields. The x-ray array was generated by a CNT cathode array (5×10) chip with electron field emission. A dose rate on the order of >1.2 Gy∕min per x-ray pixel beam is achieved at the center of the irradiated volume. The measured dose rate is in good agreement with the Monte Carlo simulation result.
PROXIMATE ANALYSIS AND PHYTOCHEMICAL INVESTIGATION OF AQUEOUS LEAF EXTRACT OF LEPIDIUM SATIVUM LINN
Creators: name: Attahiru, Ahmed
name: Haruna, Yusuf
Publisher: name: Zenodo
Year: 2024

description: Lepidium sativum is eaten as a vegetable plant. Its seed, root, and above ground parts are also used for medication. Garden cress also contains chemicals that might help fight some bacteria and viruses. Proximate analysis is very important because it provides respected information about the composition of food samples, which include crude fibre, crude lipid, crude protein ash, carbohydrate and moisture contents. This information is valuable in many aspects of the food industry, including product development, quality control, and regulatory purposes. This research work is aimed at proximate analysis and phytochemical analysis of Lepidium sativum leaves. The sample was collected in Sokoto Central Market, Sokoto State. Cold maceration method was used for extraction using aqueous solvent. Methods described by Association of Official and Analytical Chemist (AOAC) was used in carrying out this analysis. Results of nutritional investigation showed the content of Moisture (5.17±0.28 %), Ash (15.17±0.28 %), Crude lipid (2.83±0.40 %), Crude fibre (6.17±0.28 %), Crude protein (14.56±0.22 %) and Carbohydrate (61.28±0.38 %). The results of phyto-constituents showed that Saponins, Tannins, Alkaloids, Steroids, Flavonoids, Anthraquinones and Terpenoids were detected. The results of proximate analysis showed high content of protein which is play a role in development of our body diet. They also contain an element 'building blocks' known as amino acids which can be used as a source of energy. The results also showed high content of carbohydrate which is act as an energy source, help control blood glucose and insulin metabolism, participate in cholesterol and triglyceride metabolism, and help with fermentation.
The Effects of Interspersed Retrieval Practice in Multiple-List Learning on Initially Studied Material
Creators: name: Kliegl, Oliver
name: Kriechbaum, Verena M.
name: Bäuml, Karl-Heinz
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: multiple-list task, testing effect, retrieval practice, initial study list, study material
subject: 150 Psychologie

description: The forward testing effect (FTE) refers to the finding that retrieval practice of previously studied material can facilitate retention of newly studied material more than does restudy of the material. The goal of the present study was to examine how such retrieval practice affects initially studied, unpracticed material. To this end, we used two commonly applied versions of the FTE task, consisting of either three (Experiment 1) or five (Experiment 2) study lists. While study of list 1 was always followed by an unrelated distractor activity, study of list 2 (3-list version) or lists 2, 3, and 4 (5-list version) was followed by either interim restudy or retrieval practice of the immediately preceding list. After studying all lists, participants were either asked to recall the first or last study list. Results showed that, for both the three-list and five-list versions, interim retrieval practice led to a typical FTE, irrespective of whether unrelated or categorized study lists were used. Going beyond the prior work, interim retrieval practice was found to have no effect on initially studied, unpracticed material, regardless of the type of study material. The findings suggest that using interim retrieval practice as a study method can improve recall of the last studied list without incurring a cost for the initially studied material. Our results are difficult to align with the view that retrieval practice induces context change, but are consistent with the idea that retrieval practice can lead participants to employ superior encoding strategies.
The glassy random laser: replica symmetry breaking in the intensity fluctuations of emission spectra
Creators: name: Antenucci, Fabrizio
name: Crisanti, Andrea
name: Leuzzi, Luca
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The behavior of a newly introduced overlap parameter is analyzed, measuring the correlation between intensity fluctuations of waves in random media in different physical regimes, with varying amount of disorder and non-linearity. Its relationship is established to the standard Parisi overlap order parameter in replica theory for spin-glasses. In the complex spherical spin-glass model, describing the onset and behavior of random lasers, replica symmetry breaking in the intensity fluctuation overlap is shown to occur at high pumping or low temperature. This order parameter identifies the laser transition in random media and describes its glassy nature in terms of emission spectra data, the only data so far accessible in random laser measurements. The theoretical analysis is, eventually, compared to recent intensity fluctuation overlap measurements demonstrating the validity of the theory and providing a straightforward interpretation of different spectral behaviors in different random lasers.
description: 11 pages, 3 figures
A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein
Creators: name: Rathakrishnan, Anusyah
name: Reis, Ana L.
name: Petrovan, Vlad
name: Goatley, Lynnette C.
name: Moffat, Katy
name: Lui, Yuan
name: Vuong, Mai T.
name: Ikemizu, Shinji
name: Davis, Simon J.
name: Dixon, Linda K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in which single or double amino acid substitutions were introduced to reduce or abrogate the binding to red blood cells and reduce virus persistence in blood. The mutant CD2v proteins were expressed at similar levels to the wildtype protein on the surface of infected cells. Three recombinant viruses also had K145R, EP153R, and in one virus DP148R genes deleted. Following immunization of pigs, the virus with a single amino acid substitution in CD2v, Q96R, induced moderate levels of replication, and 100% protection against virulent ASFV. Two additional recombinant viruses had two amino acid substitutions in CD2v, Q96R, and K108D, and induced no binding to red blood cells in vitro. In immunized pigs, reduced levels of virus in blood and strong early ASFV-specific antibody and cellular responses were detected. After challenge low to moderate replication of challenge virus was observed. Reduced clinical signs post-challenge were observed in pigs immunized with the virus from which DP148R gene was deleted. Protection levels of 83–100% were maintained across a range of doses. Further experiments with virus GeorgiaΔDP148RΔK145RΔEP153R-CD2v_mutantQ96R/K108D showed low levels of virus dissemination in tissue and transient clinical signs at high doses. The results support further evaluation of GeorgiaΔDP148RΔK145RΔEP153R-CD2v_mutantQ96R/K108D as a vaccine candidate.
A volume-based approach to the multiplicative ergodic theorem on Banach spaces
Creators: name: Blumenthal, Alex
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37H15

description: A volume growth-based proof of the Multiplicative Ergodic Theorem for Banach spaces is presented, following the approach of Ruelle for cocycles acting on a Hilbert space. As a consequence, we obtain a volume growth interpretation for the Lyapunov exponents of a Banach space cocycle.
description: 24 pages; v2 corrects an error in the proof of Lemma 3.2
A first generation compact microbeam radiation therapy system based on carbon nanotube X-ray technology
Creators: name: Laganis, P.
name: Burk, L.
name: Zhou, O.
name: Zhang, J.
name: Yuan, H.
name: Sprenger, F.
name: Zhang, L.
name: Lu, J.
name: Chang, S.
name: Shan, J.
name: Hadsell, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We have developed a compact microbeam radiation therapy device using carbon nanotube cathodes to create a linear array of narrow focal line segments on a tungsten anode and a custom collimator assembly to select a slice of the resulting wedge-shaped radiation pattern. Effective focal line width was measured to be 131 μm, resulting in a microbeam width of ∼300 μm. The instantaneous dose rate was projected to be 2 Gy/s at full-power. Peak to valley dose ratio was measured to be >17 when a 1.4 mm microbeam separation was employed. Finally, multiple microbeams were delivered to a mouse with beam paths verified through histology.
Gestão do autoarquivamento no RI UFRN: utilizando scripts de automação com o Google Colab
Creators: name: Marques, Clediane de Araújo Guedes
name: Oliveira, Hugo Thiago de Holanda
name: Barbosa, Marta Maíra Brito
Publisher: name: Zenodo
Year: 2022

description: Apresentação realizada na sessão O meu Póster em 40 segundos da 13ª Conferência Lusófona de Ciência Aberta, formato híbrido, de 10 a 12 de outubro de 2022.
A spectroscopical analysis of the phase diagram of Yang-Mills-Higgs theory
Creators: name: Maas, Axel
name: Mufti, Tajdar
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Yang-Mills-Higgs theory, being the standard-model Higgs sector for a suitable choice of gauge and custodial group, offers a rich set of physics. In particular, in some region of its parameter space it has QCD-like behavior, while in some other region it is Higgs-like. Therefore, it is possible to study a plethora of phenomena within a single theory. Here, the physics of the standard-model version is studied using lattice gauge theory. To this end, the low-lying spectrum in several different channels is obtained for more than 140 different sets of bare parameters throughout the phase diagram. The theory shows quite different behaviors in the different regions, from almost Yang-Mills-like to the one of an essentially free gas of massive photons. Especially, not always is the behavior as naively expected.
description: 66 pages, 39 figures, 7 tables. In v2: One quantum number channel removed due to an error. Remainder essentially unchanged and all major results and conclusions remain valid - essentially removal of bonus information. In v3: Added appendix on systematic errors added, some minor improvements and a little bit larger data set, version to appear in PRD
Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site
Creators: name: Collins, Leonard B.
name: Di Giulio, Richard T.
name: Swenberg, James A.
name: Cho, Youngeun
name: Jung, Dawoon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Benzo[a]pyrene (BaP) is a known genotoxicant that affects both mitochondrial and nuclear DNA (mtDNA, nDNA). Here, we examined mtDNA and nDNA damage in the Atlantic killifish (Fundulus heteroclitus) from a highly contaminated Superfund site (Elizabeth River, VA, USA) and from a reference site (King’s Creek, VA, USA) that were dosed with 10 mg/kg BaP. Using the long amplicon quantitative PCR technique, we observed similar increases in mitochondrial and nuclear DNA damage in King’s Creek fish treated with BaP. Killifish from the Elizabeth River showed high levels of basal nDNA and mtDNA damage compared to fish from the reference site, but the level of damage induced due to BaP treatment was much lower in Elizabeth River killifish compared to King’s Creek fish. Laboratory-reared offspring from both populations showed increased BaP-induced damage in mtDNA, relative to nDNA. Similar to the adult experiment, the Elizabeth River larvae had higher levels of basal DNA damage than those from the reference site, but were less impacted by BaP exposure. Measurements of oxidative DNA damage (8-oxo-deoxyguanine by LC-MS/MS) showed no differences among treatment groups, suggesting that the majority of DNA damage is from covalent binding of BaP metabolites to DNA. This study shows for the first time that mitochondria can be an important target of BaP toxicity in fish, indicating that BaP exposures could have important energetic consequences. Results also suggest that multi-generational exposures in the wild may lead to adaptations that dampen DNA damage arising from BaP exposure.
Polycyclic Aromatic Hydrocarbon–DNA Adducts and Breast Cancer: A Pooled Analysis
Creators: name: Wang, Qiao
name: Hatch, Maureen
name: Terry, Mary Beth
name: Sagiv, Sharon K.
name: Neugut, Alfred I.
name: Wang, Lian Wen
name: Levin, Bruce
name: Eng, Sybil M.
name: Wolff, Mary S.
name: Stellman, Steve D.
name: Beyea, Jan
name: Teitelbaum, Susan L.
name: Kabat, Geoffrey C.
name: Britton, Julie A.
name: Gammon, Marilie D.
name: Shantakumar, Sumitra
name: Gaudet, Mia M.
name: Santella, Regina M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors’ pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with non-detectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.
A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein
Creators: name: Rathakrishnan, Anusyah
name: Reis, Ana L.
name: Petrovan, Vlad
name: Goatley, Lynnette C.
name: Moffat, Katy
name: Lui, Yuan
name: Vuong, Mai
name: Ikemizu, Shinji
name: Davis, Simon
name: Dixon, Linda K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in which single or double amino acid substitutions were introduced to reduce or abrogate the binding to red blood cells and reduce virus persistence in blood. The mutant CD2v proteins were expressed at similar levels to the wildtype of protein on the surface of infected cells. Three recombinant viruses also had K145R, EP153R and in one virus DP148R genes deleted. Following immunisation of pigs, the virus with a single amino acid substitution in CD2v, Q96R, induced moderate levels of replication and 100% protection against virulent ASFV. Two additional recombinant viruses had two amino acid substitutions in CD2v, Q96R and K108D, and induced no binding to red blood cells in vitro. In immunised pigs, reduced levels of virus in blood and strong early ASFV specific antibody and cellular responses were detected. After challenge, 83 to 100% protection with low to moderate replication of challenge virus were observed. Reduced clinical signs post-challenge were observed in pigs immunised with the virus from which DP148R gene was deleted. Protection levels of 83 to 100% were maintained across a range of doses. Further experiments with virus GeorgiaΔDP148RΔK145RΔEP153R-CD2v_mutantQ96R/K108D, showed low levels of virus dissemination in tissue and transient clinical signs at high doses. The results support further evaluation of GeorgiaΔDP148RΔK145RΔEP153R-CD2v_mutantQ96R/K108D as a vaccine candidate.
Design and manufacture of functional titanium–palladium devices for the activation of anti-cancer prodrugs
Creators: name: Alqahtani, Mohammad
Publisher: name: Figshare
Year: 2019
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: National health organisations and authorities have reported an increment in death cases due to cancer. To overcome this issue and improve the survival rate, it is needed to find new clinical methods, early diagnoses techniques and treatments. Radiation and chemotherapy have been used for years to treat cancer. However, these types of treatments have serious side effects such as hair loosing, the mortality of healthy cells and other organs. A new treatment based on prodrugs therapy is in development with the intention to reduce these side effects or to replace the harmful treatments completely. Prodrug treatments need an activation agent, i.e. a catalyst, to convert the prodrug delivered to the cancerous cells to an active drug in-situ. Metals such as palladium can be used as a catalyst to activate the prodrug in targeted cancer cells. In this PhD study, the research was divided into two major aspects. The first aspect was to design and manufacture a catalyst carrier with specific properties and specifications such as biocompatibility of the materials used as the carrier, suitable mechanical properties to withstand physiological loads and conditions, and cost efficiency of the production. Two different manufacturing methods were used, Powder Metallurgy technique and Arc Melting technique, to achieve the optimal fabrication method. The carriers were characterised via XRD, SEM, EDS, DSC methods and mechanical tests to ensure the carrier meets the requirements. In the second stage, the carriers were coated with Palladium in its metallic state (i.e. Pd0). The coating was required to meet the requirements of being unalloyed, pure and free of any contamination, and its deposition cost and time effective. Four coating methods were employed. Powder Metallurgy technique and sintering (with and without space holder), Magnetron Sputtering, Pulsed Laser Deposition and Supersonic Beam Cluster Deposition methods were used to apply Palladium coating onto the carriers. The coating was characterised by XPS, XRD, FIB, XRF, SEM, EDS, biochemical and in-situ biological tests. The results obtained confirmed that the devices achieve high biocompatibility of the materials, and an excellent superelasticity can withstand the loads inside the human body. Also, the Magnetron sputtering methods as a coating method demonstrated it is the most effective for achieving a uniform and long-lasting deposited layer. The devices were able to activate a clinically approved prodrug.