cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of EGFR in influenza pathogenicity: Multiple network-based approaches to identify a key regulator of non-lethal infections
Creators: name: Stratton, Kelly G.
name: Mitchell, Hugh D.
name: Sims, Amy C.
name: Bramer, Lisa M.
name: McDermott, Jason E.
name: Le, Mai Q.
name: Gralinski, Lisa E.
name: Heller, Natalie C.
name: Baric, Ralph S.
name: Waters, Katrina
name: Kawaoka, Yoshihiro
name: Wen, Ji
name: Eisfeld, Amie J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection and effective management of highly pathogenic influenza virus disease. We applied a network-based modeling approach to identify critical functions related to influenza virus pathogenicity using large transcriptomic and proteomic datasets from mice infected with six influenza virus strains or mutants. Our analysis revealed two pathogenicity-related gene expression clusters; these results were corroborated by matching proteomics data. We also identified parallel downstream processes that were altered during influenza pathogenesis. We found that network bottlenecks (nodes that bridge different network regions) were highly enriched in pathogenicity-related genes, while network hubs (highly connected network nodes) were significantly depleted in these genes. We confirmed that this trend persisted in a distinct virus: Severe Acute Respiratory Syndrome Coronavirus (SARS). The role of epidermal growth factor receptor (EGFR) in influenza pathogenesis, one of the bottleneck regulators with corroborating signals across transcript and protein expression data, was tested and validated in additional mouse infection experiments. We demonstrate that EGFR is important during influenza infection, but the role it plays changes for lethal versus non-lethal infections. Our results show that by using association networks, bottleneck genes that lack hub characteristics can be used to predict a gene’s involvement in influenza virus pathogenicity. We also demonstrate the utility of employing multiple network approaches for analyzing host response data from viral infections.
Gray matter abnormalities in addicts: A neuroimaging meta-analysis
Creators: name: Lu, Chun-lei
name: Zheng, Hui
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychiatry and Psychology
subject: Diseases
subject: Medicine and Health Sciences
subject: Mental and Social Health
subject: addiction
subject: gram matter
subject: meta
subject: VBM

description: There are many researches on addiction and gray matter abnormalities. But no study compares the gray matter abnormalities among various types of addiction. We try to explore this issue.
Musikterapi og psykiatrifonden
Creators: name: Lindhart, Anne
Publisher: name: Musikterapi i Psykiatrien Online
Year: 2015

description: Tale ved musikterapiklinikkens 20 års jubilæum
description: Musikterapi i Psykiatrien Online, Årg. 9 Nr. 2 (2014): Musikterapi i psykiatrien online 9(2)
Optimal Size for Maximal Energy Efficiency in Information Processing of Biological Systems Due to Bistability
Creators: name: Zhang, Chi
name: Liu, Li-Wei
name: Wang, Long-Fei
name: Yue, Yuan
name: Yu, Lian-Chun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Energy efficiency is closely related to the evolution of biological systems and is important to their information processing. In this paper, we calculated the excitation probability of a simple model of a bistable biological unit in response to pulsatile inputs, and its spontaneous excitation rate due to noise perturbation. Then we analytically calculated the mutual information, energy cost, and energy efficiency of an array of these bistable units. We found that the optimal number of units could maximize this array's energy efficiency in encoding pulse inputs, which depends on the fixed energy cost. We conclude that demand for energy efficiency in biological systems may strongly influence the size of these systems under the pressure of natural selection.
description: 5 pages, 3 figures, submitted to Chinese Physics Letter
Sangværksted i Psykosesøjlen
Creators: name: Dammeyer, Charlotte
Publisher: name: Musikterapi i Psykiatrien Online
Year: 2015

description: Oplæg ved musikterapiklinikkens 20 års jubilæum oktober 2014, Aalborg Universitetshospital – psykiatrien
description: Musikterapi i Psykiatrien Online, Årg. 9 Nr. 2 (2014): Musikterapi i psykiatrien online 9(2)
Genetic and environmental influences on disgust proneness, contamination sensitivity, and their covariance
Creators: name: Tybur, Joshua
name: Wesseldijk, Laura
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: contamination
subject: contamination sensitivity
subject: disgust
subject: disgust proneness
subject: disgust sensitivity
subject: genetics
subject: heritability
subject: obsessive compulsive disorder
subject: OCD
subject: twin study

description: This registration contains data and supporting material from Genetic and Environmental Influences on Disgust Proneness, Contamination Sensitivity, and Their Covariance. DOI: 10.1177/2167702620951510
The use of indicators for promoting and monitoring the implementation of economic social and cultural rights : towards the construction of Human Rights Indicators in the area of economic, social and cultural rights : an analysis of the reporting system under Article 19 of the Protocol of San Salvador
Creators: name: Méndez Jaramillo, Ana Maria
Publisher: name: My University
Year: 2015
Subjects: American Convention on Human Rights. Protocol of San Salvador. Art. 19
human rights monitoring

description: Second semester University: Maastricht University.
description: The use of qualitative and quantitative indicators has become an increasingly used tool in the human rights community at the international, regional and national level. Nevertheless, the term “indicator” has been used indistinctly to refer to, for instance, the assessment of human development issues, the different data-generating mechanisms, as well as the existing instruments used to analyse realisation of human rights. In light of this, the construction of an adequate conceptual framework to identify specific indicators with a human rights-based approach has becomes a necessity, especially for measuring efforts of States when implementing its human rights obligations. Acknowledging the existence of a gap between the formal adjudication of Economic, Social and Cultural Rights and their uneven levels of enjoyment, this thesis suggests the construction of an appropriate concept of Human Rights Indicators, as a mechanism for strengthening their implementation. The analysis will be based on two measurement models: the model proposed by the Office of the United Nations High Commissioner for Human Rights in 2012, to be applied in the universal system of human rights; and the one approved by the Organisation of American States in 2012, and afterwards in 2014, to be applied in the Inter-American system of human rights, with regards to the periodic reports on the progressive measures taken by States to ensure the rights contained in the Protocol of San Salvador.
Phd projekt – Udvikling af den terapeutiske relation i musikterapi med retspsykiatriske patienter
Creators: name: Frederiksen, Britta
Publisher: name: Musikterapi i Psykiatrien Online
Year: 2015

description: Oplæg ved musikterapiklinikkens 20 års jubilæum oktober 2014, Aalborg Universitetshospital - psykiatrien.
description: Musikterapi i Psykiatrien Online, Årg. 9 Nr. 2 (2014): Musikterapi i psykiatrien online 9(2)
title: L'ennui dans le quotidien
title: vécu des personnes bénéficiant d'un suivi en santé mentale
titleType: Subtitle
title: L'ennui dans le quotidien
titleType: AlternativeTitle
Creators: name: Volpato, Emma
name: Wibel, Julie
name: Wicht, Jonathan
Publisher: name: Unknown
Year: 0
Subjects: subject: Ennui
subject: Quotidien
subject: Vécu
subject: Santé mentale
subject: Ergothérapie

description: Introduction : L’ennui, un sentiment complexe qui interroge la sphère scientifique, a des effetsambivalents. Il inciterait à rechercher des activités stimulantes mais conduirait aussi à la dépression, l’anxiété, l’agressivité et des comportements impulsifs. Certaines populations,comme celles concernées par des troubles psychiques, sont particulièrement vulnérables àl’ennui. Ce travail de Bachelor explore, à travers une perspective ergothérapeutique, comment ces personnes vivent l’ennui au quotidien. But : Ce travail de Bachelor vise à explorer, décrire et saisir l’expérience vécue de l’ennui auquotidien chez des personnes bénéficiant ou ayant bénéficié d’un suivi thérapeutique dans la communauté pour des troubles psychiques, selon leur propre perspective. Méthode : Cette étude qualitative a été réalisée avec un design descriptif interprétatif. Six entretiens individuels ont été menés auprès de six participant·es (n=6) vivant dans la communauté. Les entretiens étaient de type semi dirigé et un collage a été utilisé comme facilitateur pour la discussion. Résultats : Cette étude a permis de découvrir de nouveaux thèmes et des perspectives spécifiques à l’ennui, qui n’avaient pas encore été explorées dans la littérature existante. L’analyse des entretiens a permis d’identifier les dix thématiques suivantes : entrer dans l'ennui intrinsèque, entrer dans l'ennui extrinsèque, tout faire pour ne pas entrer dans l’ennui,représentations de l'ennui, les ressentis vécus durant l'ennui, déconnexion pour ne plus ressentir de l’ennui, rester à flot, dualité de l’ennui : choisi ou subi, sortie de l'ennui intrinsèque,sortie de l'ennui extrinsèque. Conclusion : À partir d’une revue de la littérature scientifique et de six entretiens individuels,cette enquête a mis en lumière l’importance du ressenti et du vécu des participant·es. Ce travail vise à aider les professionnel·les de la santé, notamment les ergothérapeutes, à mieux comprendre et intervenir auprès des personnes souffrant d’ennui. [Résumé des auteurs].
Preregistration - Rothgerber_covid_BNrd - Freeman - Computational Reproduction - 378
Creators: name: Freeman, Alexandra
name: Schneider, Claudia
name: Kerr, John
name: Fox, Nicholas
name: Loomas, Zachary
name: Miske, Olivia
name: Luis, Brianna
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: Reproduction of a research claim from Rothgerber et al. (2020), from PsyArXiv The purpose of this reproduction attempt is to assess whether we can reproduce the analytic result as it was reported in the original paper by using the original data. The original data will be analyzed by following the same analytic approach described in the original paper (as close to the same analytic approach as possible based on the level of detail available in the original paper, as well as any supplementary materials or additional information provided by the original author). All SCORE projects target a single inferential statistical test that supports a statement from the abstract of the original paper. The research claim and focal analysis for this paper are provided below. Research claim: We selected Hypothesis 1: More conservative participants would be less likely to follow social distancing guidelines. This reflects the following statement from the paper’s abstract: “Specifically, political conservatism inversely predicted compliance with behaviors aimed at preventing the spread of the COVID-19.” To model the causal pathway from conservatism to reported social distancing, multiple regression analyses provided model parameter estimates. Regression revealed a significant total effect of conservatism on social distancing (B = -.20, p < .001), supporting Hypothesis 1 that compliance with social distancing guidelines is inversely related to conservatism. Focal inferential test: Regression revealed a significant total effect of conservatism on social distancing (B = -.20, p < .001), supporting Hypothesis 1 that compliance with social distancing guidelines is inversely related to conservatism.
STUDY OF THE IMMUNOLOGIC AND HEMATOLOGIC PROFILE OF CHILDREN ON HAART: A RETROSPECTIVE COHORT STUDY AT ZEWDITU MEMORIAL HOSPITAL
Creators: name: Abebe Habte Selassie
Publisher: name: Zenodo
Year: 2014

description: Background: In HIV infected individuals immunologic and hematologic abnormalities are common and they increase the risk of morbidity and mortality. However little is known about the profile of immunologic and hematologic abnormalities in Ethiopia in those children who are on Highly Active Antiretroviral Therapy. Evaluating the haematological and immunological parameters in HIV/ AIDS patients on HAART is important in order to monitor the body responses to the drugs. Therefore, assessment of haematological and immunological changes in HIV/ AIDS patients in HAART is of a paramount importance. Objective: the main objective of this study was to assess immunologic and hematologic profile of HIV infected children on highly active antiretroviral therapy in Zewditu Memorial Hospital.
Remote Key Establishment by Mode Mixing in Multimode Fibres and Optical Reciprocity
Creators: name: Bromberg, Yaron
name: Redding, Brandon
name: Popoff, Sebastien M.
name: Cao, Hui
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Disorder and scattering in photonic systems have long been considered a nuisance that should be circumvented. Recently, disorder has been harnessed for a rapidly growing number of applications, including imaging, sensing and spectroscopy. The chaotic dynamics and extreme sensitivity to external perturbations make random media particularly well-suited for optical cryptography. However, using random media for distribution of secret keys between remote users still remains challenging, since it requires the users have access to the same scattering system. Here we utilize random mode mixing in multimode fibres to generate and distribute keys simultaneously. Fast fluctuations in the fibre mode mixing provide the source of randomness for the key generation, and optical reciprocity guarantees that the keys at the two ends of the fibre are identical. We experimentally demonstrate the scheme using classical light and off-the-shelf components, opening the door for cost effective key establishment at the physical-layer of fibre-optic networks.
description: Comments are welcome
Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination
Creators: name: Lindesmith, Lisa C.
name: Costantini, Veronica
name: Ippolito, Gregory C.
name: Blazeck, John J.
name: Georgiou, George
name: Vinje, Jan
name: Voss, William N.
name: Baric, Ralph S.
name: Boutz, Daniel R.
name: Brewer-Jensen, Paul D.
name: Changela, Anita
name: McDaniel, Jonathan R.
name: Kwong, Peter D.
name: Kerr, Scott A.
name: Mallory, Michael L.
name: Verardi, Raffaello
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Rapidly evolving RNA viruses, such as the GII.4 strain of human norovirus (HuNoV), and their vaccines elicit complex serological responses associated with previous exposure. Speciﬁc correlates of protection, moreover, remain poorly understood. Here, we report the GII.4-serological antibody repertoire—pre- and post-vaccination—and select several anti-body clonotypes for epitope and structural analysis. The humoral response was dominated by GII.4-speciﬁc antibodies that blocked ancestral strains or by antibodies that bound to divergent genotypes and did not block viral-entry-ligand interactions. However, one antibody, A1431, showed broad blockade toward tested GII.4 strains and neutralized the pandemic GII.P16-GII.4 Sydney strain. Structural mapping revealed conserved epitopes, which were occluded on the virion or partially exposed, allowing for broad blockade with neutralizing activity. Overall, our results provide high-resolution molecular information on humoral immune responses after HuNoV vaccination and demonstrate that infection-derived and vaccine-elicited antibodies can exhibit broad blockade and neutralization against this prevalent human pathogen.
A risk-stratified approach to bowel cancer screening: a scoping review
Creators: name: Cairns, Joanne
name: Bamidele, Olufikayo
name: Greenley, Sarah
name: Weller, David
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: This is a scoping review protocol for the project title 'A risk-stratified approach to bowel cancer screening'
Beyond Neutralizing Antibody Levels: The Epitope Specificity of Antibodies Induced by National Institutes of Health Monovalent Dengue Virus Vaccines
Creators: name: Durbin, Anna P.
name: Swanstrom, Jesica A.
name: Whitehead, Stephen S.
name: Baric, Ralph S.
name: Patel, Bhumi
name: de Silva, Aravinda M.
name: Nivarthi, Usha K.
name: Yount, Boyd
name: Delacruz, Matthew J.
name: Widman, Douglas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Background. Dengue virus is an emerging mosquito-borne flavivirus responsible for considerable morbidity and mortality
worldwide. The Division of Intramural Research, National Institute of Allergy and Infectious Diseases of the US National Institutes
of Health (NIH) has developed live attenuated vaccines to each of the 4 serotypes of dengue virus (DENV1–4). While overall levels of
DENV neutralizing antibodies (nAbs) in humans have been correlated with protection, these correlations vary depending on DENV
serotype, prevaccination immunostatus, age, and study site. By combining both the level and molecular specificity of nAbs to each
serotype, it may be possible to develop more robust correlates that predict long-term outcome.
Methods. Using depletions and recombinant chimeric epitope transplant DENVs, we evaluate the molecular specificity and
mapped specific epitopes and antigenic regions targeted by vaccine-induced nAbs in volunteers who received the NIH monovalent
vaccines against each DENV serotype.
Results. After monovalent vaccination, subjects developed high levels of nAbs that mainly targeted epitopes that are unique
(type-specific) to each DENV serotype. The DENV1, 2, and 4 monovalent vaccines induced type-specific nAbs directed to quaternary
structure envelope epitopes known to be targets of strongly neutralizing antibodies induced by wild-type DENV infections.
Conclusions. Our results reported here on the molecular specificity of NIH vaccine–induced antibodies enable new strategies,
beyond the absolute levels of nAbs, for determining correlates and mechanisms of protective immunity.
Musikterapi i psykiatrien online 9(2)
Creators: name: Pedersen, Inge Nygaard
name: Jensen, Susanne
name: Stigel, Jørgen
name: Vetner, Mikael
name: Aagaard, Jørgen
name: Lindhart, Anne
name: Hannibal, Niels
name: Bonde, Lars Ole
name: Bertelsen, Lars Rye
name: Niedermann, Peter
name: Dammeyer, Charlotte
name: Storm, Sanne
name: Frederiksen, Britta
Publisher: name: Musikterapi i Psykiatrien Online
Year: 2015

description: Musikterapi i psykiatrien online 9(2), samlet udgave
description: Musikterapi i Psykiatrien Online, Årg. 9 Nr. 2 (2014): Musikterapi i psykiatrien online 9(2)
Supplementary document for Confocal reflectance microscopy for mapping collagen fiber organization in the vitreous gel of the eye - 6144788.pdf
Creators: name: Hwang, Eileen
name: Morgan, Denise
name: Sun, Jieliyue
name: Hartnett, Mary
name: Toussaint, Kimani
name: Coats, Brittany
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplement 1
Modulus of continuity of some conditionally sub-Gaussian fields, application to stable random fields
Creators: name: Biermé, Hermine
name: Lacaux, Céline
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: In this paper, we study modulus of continuity and rate of convergence of series of conditionally sub-Gaussian random fields. This framework includes both classical series representations of Gaussian fields and LePage series representations of stable fields. We enlighten their anisotropic properties by using an adapted quasi-metric instead of the classical Euclidean norm. We specify our assumptions in the case of shot noise series where arrival times of a Poisson process are involved. This allows us to state unified results for harmonizable (multi)operator scaling stable random fields through their LePage series representation, as well as to study sample path properties of their multistable analogous.
description: Published at http://dx.doi.org/10.3150/14-BEJ619 in the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
STAT5: A target of antagonism by neurotropic flaviviruses
Creators: name: Zimmerman, Matthew G.
name: McDonald, Circe E.
name: Pulendran, Bali
name: Bowen, James R.
name: Baric, Ralph S.
name: Suthar, Mehul S.
name: Young, Ellen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Flaviviruses are a diverse group of arthropod-borne viruses responsible for numerous significant public health threats; therefore, understanding the interactions between these viruses and the human immune response remains vital. West Nile virus (WNV) and Zika virus (ZIKV) infect human dendritic cells (DCs) and can block antiviral immune responses in DCs. Previously, we used mRNA sequencing and weighted gene coexpression network analysis (WGCNA) to define molecular signatures of antiviral DC responses following activation of innate immune signaling (RIG-I, MDA5, or type I interferon [IFN] signaling) or infection with WNV. Using this approach, we found that several genes involved in T cell cosignaling and antigen processing were not enriched in DCs during WNV infection. Using cis-regulatory sequence analysis, STAT5 was identified as a regulator of DC activation and immune responses downstream of innate immune signaling that was not activated during either WNV or ZIKV infection. Mechanistically, WNV and ZIKV actively blocked STAT5 phosphorylation downstream of RIG-I, IFN-β, and interleukin-4 (IL-4), but not granulocyte-macrophage colony-stimulating factor (GM-CSF), signaling. Unexpectedly, dengue virus serotypes 1 to 4 (DENV1 to DENV4) and the yellow fever 17D vaccine strain (YFV-17D) did not antagonize STAT5 phosphorylation. In contrast to WNV, ZIKV inhibited JAK1 and TYK2 phosphorylation following type I IFN treatment, suggesting divergent mechanisms used by these viruses to inhibit STAT5 activation. Combined, these findings identify STAT5 as a target of antagonism by specific pathogenic flaviviruses to subvert the immune response in infected DCs.

IMPORTANCE Flaviviruses are a diverse group of insect-borne viruses responsible for numerous significant public health threats. Previously, we used a computational biology approach to define molecular signatures of antiviral DC responses following activation of innate immune signaling or infection with West Nile virus (WNV). In this work, we identify STAT5 as a regulator of DC activation and antiviral immune responses downstream of innate immune signaling that was not activated during either WNV or Zika virus (ZIKV) infection. WNV and ZIKV actively blocked STAT5 phosphorylation downstream of RIG-I, IFN-β, and IL-4, but not GM-CSF, signaling. However, other related flaviviruses, dengue virus serotypes 1 to 4 and the yellow fever 17D vaccine strain, did not antagonize STAT5 phosphorylation. Mechanistically, WNV and ZIKV showed differential inhibition of Jak kinases upstream of STAT5, suggesting divergent countermeasures to inhibit STAT5 activation. Combined, these findings identify STAT5 as a target of antagonism by specific pathogenic flaviviruses to subvert antiviral immune responses in human DCs.
An Exo-Jupiter Candidate in the Eclipsing Binary FL Lyr
Creators: name: Kozyreva, V. S.
name: Bogomazov, A. I.
name: Demkov, B. P.
name: Zotov, L. V.
name: Tutukov, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Light curves of the eclipsing binary FL Lyr acquired by the Kepler space telescope are analyzed. Eclipse timing measurements for FL Lyr testify to the presence of a third body in the system. Preliminary estimates of its mass and orbital period are > 4M_Jupiter and > 7 yrs. The times of primary minimum in the light curve of FL Lyr during the operation of the Kepler mission are presented.
description: 37 pages, 8 figures, 4 tables, corrected an error in 'simple mass estimation' of the third body and journal reference
Forside, kolofon, indholdsfortegnelse
Creators: name:  , Redaktionelt
Publisher: name: Musikterapi i Psykiatrien Online
Year: 2015

description: redaktionelt
description: Musikterapi i Psykiatrien Online, Årg. 9 Nr. 2 (2014): Musikterapi i psykiatrien online 9(2)
Envelope protein glycosylation mediates Zika virus pathogenesis
Creators: name: Carbaugh, Derek L.
name: Baric, Ralph S.
name: Lazear, Helen M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Zika virus (ZIKV) is an emerging mosquito-borne flavivirus. Recent ZIKV outbreaks have produced serious human disease, including neurodevelopmental malformations (congenital Zika syndrome) and Guillain-Barré syndrome. These outcomes were not associated with ZIKV infection prior to 2013, raising the possibility that viral genetic changes could contribute to new clinical manifestations. All contemporary ZIKV isolates encode an N-linked glycosylation site in the envelope (E) protein (N154), but this glycosylation site is absent in many historical ZIKV isolates. Here, we investigated the role of E protein glycosylation in ZIKV pathogenesis using two contemporary Asian-lineage strains (H/PF/2013 and PRVABC59) and the historical African-lineage strain (MR766). We found that glycosylated viruses were highly pathogenic in Ifnar1−/− mice. In contrast, nonglycosylated viruses were attenuated, producing lower viral loads in the serum and brain when inoculated subcutaneously but remaining neurovirulent when inoculated intracranially. These results suggest that E glycosylation is advantageous in the periphery but not within the brain. Accordingly, we found that glycosylation facilitated infection of cells expressing the lectins dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) or DC-SIGN-related (DC-SIGNR), suggesting that inefficient infection of lectin-expressing leukocytes could contribute to the attenuation of nonglycosylated ZIKV in mice.

IMPORTANCE It is unclear why the ability of Zika virus (ZIKV) to cause serious disease, including Guillain-Barré syndrome and birth defects, was not recognized until recent outbreaks. One contributing factor could be genetic differences between contemporary ZIKV strains and historical ZIKV strains. All isolates from recent outbreaks encode a viral envelope protein that is glycosylated, whereas many historical ZIKV strains lack this glycosylation. We generated nonglycosylated ZIKV mutants from contemporary and historical strains and evaluated their virulence in mice. We found that nonglycosylated viruses were attenuated and produced lower viral loads in serum and brains. Our studies suggest that envelope protein glycosylation contributes to ZIKV pathogenesis, possibly by facilitating attachment to and infection of lectin-expressing leukocytes.
Heating by exciton and biexciton recombination in GaAs/AlGaAs quantum wells
Creators: name: Belykh, V. V.
name: Kochiev, M. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A comprehensive experimental investigation of exciton and biexciton recombination in GaAs/AlGaAs quantum wells is presented. Exciton and biexciton recombination times are found to be 16 and 55 ps, respectively. A method of determining the dynamics of the exciton temperature is developed. It is shown that both exciton and biexciton recombination processes increase the exciton temperature by an amount as high as $\sim 10$ K. These processes impose a new restriction on the possibility of exciton Bose-Einstein condensation and make impossible its achievement in a system of direct excitons in GaAs quantum wells even for resonantly excited exciton gas.
description: 10 pages, 6 figures, 1 table
Interplay of insurance and financial risks in a discrete-time model with strongly regular variation
Creators: name: Li, Jinzhu
name: Tang, Qihe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Consider an insurance company exposed to a stochastic economic environment that contains two kinds of risk. The first kind is the insurance risk caused by traditional insurance claims, and the second kind is the financial risk resulting from investments. Its wealth process is described in a standard discrete-time model in which, during each period, the insurance risk is quantified as a real-valued random variable $X$ equal to the total amount of claims less premiums, and the financial risk as a positive random variable $Y$ equal to the reciprocal of the stochastic accumulation factor. This risk model builds an efficient platform for investigating the interplay of the two kinds of risk. We focus on the ruin probability and the tail probability of the aggregate risk amount. Assuming that every convex combination of the distributions of $X$ and $Y$ is of strongly regular variation, we derive some precise asymptotic formulas for these probabilities with both finite and infinite time horizons, all in the form of linear combinations of the tail probabilities of $X$ and $Y$. Our treatment is unified in the sense that no dominating relationship between $X$ and $Y$ is required.
description: Published at http://dx.doi.org/10.3150/14-BEJ625 in the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
State of the environment and natural resources in Vietnam
Creators: name: Chu, Thi Thu Ha
Publisher: name: Journal of Vietnamese Environment
Year: 2014

description: Vietnam is considered as one of the countries having rich resources from forest and sea, with a high average annual rainfall. However, in view of IWRA, water volume per capita annually in Vietnam is lower than the standard for nations having water resources at average level. Vietnam was recognized by the World Wildlife Fund (WWF) as having three out of more than 200 biological zones of the world. Flora and fauna in Vietnam are very rich and abundant, but due to indiscriminate exploitation, along with weak management, biodiversity levels are significantly reduced. This is also one of the causes of environmental pollution and degradation in Vietnam, besides the impacts from production activities, population migration from rural areas to urban areas, rapid urbanization, climate change and sea level rise, etc. Việt Nam được coi là một trong những quốc gia giàu nguồn tài nguyên từ rừng và biển, có lượng mưa trung bình hàng năm cao. Tuy nhiên, lượng nước bình quân đầu người hàng năm ở Việt Nam thấp hơn so với tiêu chuẩn cho quốc gia có nguồn nước ở mức trung bình theo quan điểm của Hiệp hội nước quốc tế (IWRA). Việt Nam được Quỹ Quốc tế về Bảo vệ thiên nhiên (WWF) công nhận có 3 trong số hơn 200 vùng sinh thái toàn cầu. Hệ động thực vật ở Việt Nam rất phong phú, nhưng do vấn nạn khai thác bừa bãi, cùng với sự quản lý yếu kém, mức đa dạng sinh học đã bị giảm đáng kể. Đây cũng là một trong những nguyên nhân gây ô nhiễm và suy thoái môi trường ở Việt Nam, bên cạnh các tác động từ hoạt động sản xuất, di dân, đô thị hóa, biến đổi khí hậu và nước biển dâng, v.v...
description: Journal of Vietnamese Environment, Vol 6 No 1 (2014)
Coupling Conditions for Water Waves at Forks
Creators: name: Caputo, Jean-Guy
name: Dutykh, Denys
name: Gleyse, Bernard
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Physics (physics.class-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We considered the propagation of nonlinear shallow water waves in a narrow channel presenting a fork. We aimed at computing the coupling conditions for a 1D effective model, using 2D simulations and an analysis based on the conservation laws. For small amplitudes, this analysis justifies the well-known Stoker interface conditions, so that the coupling does not depend on the angle of the fork. We also find this in the numerical solution. Large amplitude solutions in a symmetric fork also tend to follow Stoker's relations, due to the symmetry constraint. For non symmetric forks, 2D effects dominate so that it is necessary to understand the flow inside the fork. However, even then, conservation laws give some insight in the dynamics.
description: Appeared in Symmetry (MDPI): 27 pages, 19 figures, 1 table, 20 references. Other author's papers can be downloaded at http://www.denys-dutykh.com/
Groundwater vulnerability in Vietnam and innovative solutions for sustainable exploitation
Creators: name: Stefan, Catalin
Publisher: name: Journal of Vietnamese Environment
Year: 2014

description: With an abundant average precipitation rate, Vietnam could be considered water-reach country. Unfortunately, the non-uniform spatial and temporal distribution of rainfall, coupled with a demographic and industrial development polarized on the two major river deltas, it makes the water resources extremely vulnerable. As consequence, severe depletions of groundwater table are reported all over the country, often in the range of 1-2 m per year and more. The subsequent land subsidence is just one of the drawbacks, another being the increasing salinity of coastal aquifers as sea water level continues to rise. Under these conditions, the natural groundwater replenishment alone is not anymore able to provide for a safe water supply, different studies indicating that the groundwater exploitation in major urban agglomerations like Hanoi or Ho Chi Minh City already passed the sustainability level. The solution presented in this paper implies making use of engineered methods for enhancing the natural groundwater recharge rates by enabling better percolation rates of surface water into subsurface and thus optimizing the regional water cycle. The method known as ‘managed aquifer recharge’ (MAR) is introduced, together with general guidelines and tools for planning of MAR schemes, such as the newly web-based decision support system INOWAS_DSS. Với tốc độ lượng mưa trung bình dồi dào, Việt Nam có thể được coi là quốc gia có nguồn nước trong tầm tay. Thật không may, sự phân bố không gian và thời gian không đồng đều của lượng mưa, cùng với sự phát triển dân số và công nghiệp phân cực trên hai vùng châu thổ sông lớn làm cho các nguồn nước rất dễ bị tổn thương. Vì vậy, sự suy giảm nước ngầm nghiêm trọng được báo cáo trên khắp đất nước, thường mỗi năm giảm 1-2 m và nhiều hơn nữa. Hiện tượng sụt lún đất xảy ra sau đó chỉ là một trong những hạn chế, mặt khác là độ mặn ngày càng tăng của các tầng chứa nước ven biển do mực nước biển tiếp tục tăng. Dưới những điều kiện này, việc bổ sung nước ngầm tự nhiên đơn thuần không còn có thể cung ứng cho một nguồn cấp nước sạch an toàn. Các nghiên cứu khác nhau cho thấy rằng việc khai thác nước ngầm tại các đô thị lớn như Hà Nội hay thành phố Hồ Chí Minh đã vượt qua mức độ bền vững. Giải pháp được trình bày trong bài báo này gợi ý việc sử dụng các phương pháp thiết kế để nâng cao tỷ lệ tái nạp nước ngầm tự nhiên bằng cách cho phép tỷ lệ thẩm thấu tốt hơn nước mặt vào dưới bề mặt và do đó tối ưu hóa chu trình nước trong khu vực. Phương pháp được gọi là 'tái nạp nước ngầm có quản lý' (MAR) được giới thiệu, cùng với các hướng dẫn chung và các công cụ để lập kế hoạch đề án MAR, ví dụ như hệ thống mới hỗ trợ quyết định dựa trên kết nối mạng INOWAS_DSS.
description: Journal of Vietnamese Environment, Vol 6 No 1 (2014)
Quantum Hall ferromagnets and transport properties of buckled Dirac materials
Creators: name: Luo, Wenchen
name: Chakraborty, Tapash
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the ground states and low-energy excitations of a generic Dirac material with spin-orbit coupling and a buckling structure in the presence of a perpendicular magnetic field. The ground states can be classified into three types under different conditions: SU(2), easy-plane, and Ising quantum Hall ferromagnets. For the SU(2) and the easy-plane quantum Hall ferromagnets there are goldstone modes in the collective excitations, while all the modes are gapped in an Ising-type ground state. We compare the Ising quantum Hall ferromagnet with that of bilayer graphene and present the domain wall solution at finite temperatures. We then specify the phase transitions and transport gaps in silicene in Landau levels 0 and 1. The phase diagram strongly depends on the magnetic field and the dielectric constant. We note that there exists triple points in the phase diagrams in Landau level N = 1 that could be observed in experiments.
description: 4 figures
Interdisciplinary high fidelity simulation impact on self-efficacy and knowledge in cardiopulmonary resuscitation training among nursing students: randomized controlled trial
Creators: name: TAKHDAT, Kamal
name: Mohamed, Eddabah
name: Hamza, EL
name: Ghassane, EL
name: Saloua, LAMTALI
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychiatry and Psychology
subject: Medicine and Health Sciences
subject: Education
subject: Nursing
subject: FOS: Health sciences
subject: Cardiopulmonary resuscitation
subject: High fidelity simulation
subject: interdisciplinary
subject: Knowledge
subject: Nursing student
subject: self-efficacy

description: an experimental study aiming to investigate the impact of High fidelity simulation on Self-efficacy and knowledge in CPR training among undergraduate nursing students. Undergraduate interdisciplinary nursing students (N=50) enrolled in the 2nd year (4th semester) of intensive care (n=26) and anesthesia (n=24) at a Moroccan institute of nursing professions were invited to participate in the study. All students who had signed a consent form and had no previous CPR simulation experience were eligible to participate in the study. Participants were excluded if they were physically unable to perform CPR. They were contacted directly by the researcher, informed about the study objectives and had the right to withdraw at any stage of experimentation. the study design in the attached file describe the experimentation protocol
PROTOCOL: A scoping review of outcomes commonly reported in early childhood obesity prevention interventions
Creators: name: Brown, Vicki
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: This scoping review of commonly reported outcomes in early childhood obesity prevention interventions makes up “Study 1” of a post-doctoral project. By summarising and critically analysing the outcomes reported from early childhood obesity prevention interventions, it will contribute to the development of a core outcome set for early childhood obesity prevention interventions.
Antagonism of dsRNA-induced innate immune pathways by NS4a and NS4b accessory proteins during MERS coronavirus infection
Creators: name: Weiss, Susan R.
name: Li, Yize
name: Comar, Courtney E.
name: Baric, Ralph S.
name: Goldstein, Stephen A.
name: Yount, Boyd
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in 2012 as a novel etiological agent of severe respiratory disease in humans. As during infection by other viruses, host sensing of viral double-stranded RNA (dsRNA) induces several antiviral pathways. These include interferon (IFN), oligoadenylate synthetase (OAS)-RNase L, and protein kinase R (PKR). Coronaviruses, including MERS-CoV, potently suppress the activation of these pathways, inducing only modest host responses. Our study describes the functions of two accessory proteins unique to MERS-CoV and related viruses, NS4a and NS4b, during infection in human airway epithelium-derived A549 cells. NS4a has been previously characterized as a dsRNA binding protein, while NS4b is a 2′,5′-phosphodiesterase with structural and enzymatic similarity to NS2 encoded by mouse hepatitis virus (MHV). We found that deletion of NS4a results in increased interferon lambda (IFNL1) expression, as does mutation of either the catalytic site or nuclear localization sequence of NS4b. All of the mutant viruses we tested exhibited slight decreases in replication. We previously reported that, like MHV NS2, NS4b antagonizes OAS-RNase L, but suppression of IFN is a previously unidentified function for viral phosphodiesterases. Unexpectedly, deletion of NS4a does not result in robust activation of the PKR or OAS-RNase L pathways. Therefore, MERS-CoV likely encodes other proteins that contribute to suppression or evasion of these antiviral innate immune pathways that should be an important focus of future work. This study provides additional insight into the complex interactions between MERS-CoV and the host immune response.

IMPORTANCE Middle East respiratory syndrome coronavirus (MERS-CoV) is the second novel zoonotic coronavirus to emerge in the 21st century and cause outbreaks of severe respiratory disease. More than 2,200 cases and 800 deaths have been reported to date, yet there are no licensed vaccines or treatments. Coronaviruses encode unique accessory proteins that are not required for replication but most likely play roles in immune antagonism and/or pathogenesis. Our study describes the functions of MERS-CoV accessory proteins NS4a and NS4b during infection of a human airway-derived cell line. Loss of these accessory proteins during MERS-CoV infection leads to host antiviral activation and modestly attenuates replication. In the case of both NS4a and NS4b, we have identified roles during infection not previously described, yet the lack of robust activation suggests much remains to be learned about the interactions between MERS-CoV and the infected host.
Seasonal variation of phytoplankton assemblage in Hoa Binh reservoir, north of Vietnam
Creators: name: Thi Thuy, Duong
name: Vu, Thi Nguyet
name: Le, Thi Phuong Quynh
name: Ho, Tu Cuong
name: Hoang, Trung Kien
name: Nguyen, Trung Kien
name: Dang, Dinh Kim
Publisher: name: Journal of Vietnamese Environment
Year: 2014

description: Algae provide an important role in aquatic food web and biochemical cycles in aquatic systems. They are affected by different environmental factors, such as pH, light, temperature and nutrients. This study aimed to describe the composition abundance and density of phytoplankton in the Hoa Binh reservoir during period from March to December 2011. Phytoplankton samples were collected monthly at four sampling stations. Result obtained showed that 6 phytoplankton classes were recorded: Cyanobacteria, Chlorophyceae, Bacillariophyceae, Euglenophyceae, Dinophyceae and Cryptophyceae. Bacillariophyceae and Cyanobacteria were the most abundant phytoplankton families constituting 61% and 32% respectively of total phytoplankton community. Colony-forming and solitary ﬁlamentous-forming of Cyanobacteria group (e.g. Microcystis aeruginosa, M. wesenbergi and Oscillatoria sp. respectively) were a common component of phytoplankton community in the early summer and autumn periods (April and September). The total cell densities of phytoplankton varied seasonally from 84210 to 100x106 cell/L. Phytoplankton density varied with season with high values in early summer and winter (April and December) and low values in summer – autumn periods (from June to October). Tảo đóng vai trò quan trọng trong mạng lưới thức ăn và chu trình sinh địa hóa của thủy vực và chúng chịu sự chi phối của nhiều yếu tố môi trường như ánh sáng, pH, nhiệt độ và dinh dưỡng. Nghiên cứu này trình bày đa dạng thành phần loài và biến động sinh khối thực vật phù du tại hồ chứa Hòa Bình từ tháng 3 đến tháng 12 năm 2011. Các mẫu thực vật nổi được thu thập hàng tháng tại 4 điểm. Kết quả đã xác định được 6 lớp tảo chính bao gồm: Vi khuẩn lam, tảo lục, tảo silic, tảo mắt, tảo giáp và tảo lông roi hai rãnh. Nhóm tảo silic và Vi khuẩn lam chiếm ưu thế với độ phong phú tương đối là 61% và 32% tương ứng trong quần xã thực vật nổi. Vi khuẩn lam dạng tập đoàn và dạng sợi (Microcystis aeruginosa, M. wesenberg, Oscillatoria sp. tương ứng) chiếm ưu thế trong quần xã thực vật nổi vào các thời điểm đầu hè và mùa thu (tháng 4 và tháng 9). Tổng mật độ tế bào thực vật nổi dao động từ 84210 đến 100 x106 cell/L. Mật độ thực vật nổi biển động theo mùa với sinh khối tê bào cao vào đầu hè và mùa đông (tháng 4 và tháng 12) và sinh khối tế bào thấp vào các mùa hè và thu (tháng 6 đến tháng 10).
description: Journal of Vietnamese Environment, Vol 6 No 1 (2014)
Precision mouse models with expanded tropism for human pathogens
Creators: name: Dayton, Paul A.
name: De, Chandrav
name: Boone, Allison
name: Baric, Ralph S.
name: Braunstein, Miriam
name: Sanders, Wes
name: Goonetilleke, Nilu
name: Cockrell, Adam S.
name: Hildebrand, William H.
name: Wahl, Angela
name: Garcia, J. Victor
name: Aguilera-Sandoval, Christian R.
name: Vincent, Heather A.
name: Newsome, Isabel G.
name: Johnson, Claire E.
name: Pickles, Raymond J.
name: Moorman, Nathaniel J.
name: Cleary, Rachel A.
name: Fernandez, Maria Abad
name: Rank, Laura M.
name: Lenarcic, Erik M.
name: Schramm, Nathaniel J.
name: Xu, Yinyan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells. However, most human pathogens target other cell types, including epithelial, endothelial and mesenchymal cells. Here, we show that implantation of human lung tissue, which contains up to 40 cell types, including nonhematopoietic cells, into immunodeficient mice (lung-only mice) resulted in the development of a highly vascularized lung implant. We demonstrate that emerging and clinically relevant human pathogens such as Middle East respiratory syndrome coronavirus, Zika virus, respiratory syncytial virus and cytomegalovirus replicate in vivo in these lung implants. When incorporated into bone marrow/liver/thymus humanized mice, lung implants are repopulated with autologous human hematopoietic cells. We show robust antigen-specific humoral and T-cell responses following cytomegalovirus infection that control virus replication. Lung-only mice and bone marrow/liver/thymus-lung humanized mice substantially increase the number of human pathogens that can be studied in vivo, facilitating the in vivo testing of therapeutics.