cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting immunometabolism to increase the efficacy of breast cancer immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Recently, a new type of cancer therapy known as immunotherapy has emerged, and has shown great potential for the treatment of cancer. Immunotherapy directs our own immune system to attack cancer cells, versus traditional cancer drugs that target the cancer cells directly. However, to date, responses to immunotherapy in patients with breast cancer have been limited compared to other cancers such as melanoma. One reason for this lack of success is that the immune cells that are trying to attack the cancer cells are being inhibited. This inhibition is due in part to depletion of nutrients that feed the immune cells and allow them to function. Two of these nutrients are the amino acids cysteine and arginine. The goal of this project is to show that reversing the depletion of these nutrients by disrupting their metabolism will increase the success of immunotherapy in breast cancer. We will treat mice that have breast cancer with immunotherapy that has been previously shown to have limited benefit in this model. Some mice will receive immunotherapy along with the drug Viagra, which blocks arginine metabolism. Other mice will receive immunotherapy along with agents that block cysteine metabolism. The effectiveness of treatments will be measured based on whether the mice that get nutrient metabolism-targeted agents show increased tumor shrinkage compared to mice that receive immunotherapy alone. Additionally, we will study the immune cells in these tumors to understand how they change in response to therapy. Our proposal is innovative and significant because it provides a novel strategy to treat breast cancer by combining immunotherapy with agents that reverse nutrient depletion in and around the tumor. Viagra is currently in clinical trials to help treat other types of cancers, which will speed up the translation of our findings with this agent to use in the clinic for patients with breast cancer. A demonstration that our strategies targeting cysteine metabolism can enhance immunotherapy will provide critical data to support further studies to refine these agents into actual therapeutics. The impact of these studies will be novel combination immunotherapies that fulfill the potential of this powerful new class of therapy so patients with breast cancer can enjoy the benefits of immunotherapy that patients with other types of cancer have started to benefit from.
Synthesis, molecular modeling investigation, molecular dynamic and ADME prediction of some novel Mannich bases derived from 1,2,4-triazole, and assessment of their anticancer activity
Creators: name: Manap, Sevda
name: Medetalibeyoğlu, Hilal
name: Kılıç, Ahsen
name: Karataş, Omer Faruk
name: Tüzün, Burak
name: Alkan, Muzaffer
name: Ortaakarsu, Ahmet Buğra
name: Atalay, Abdurrahman
name: Beytur, Murat
name: Yüksek, Haydar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: A series of biologically active novel Mannich bases containing with a 1H-1,2,4-triazole-5-one ring were developed to evaluate the cytotoxic activity. For this purpose, the synthesized Schiff Bases (S1-5) were reacted with formaldehyde and morpholine, which is a secondary amine to yield novel N-Mannich bases (M1-5) via the Mannich reaction. The structures of the compounds (M1-5) were determined structurally employing 1H/13C-NMR, IR and elemental analysis. In this study, we evaluated the cytotoxic potential of the compounds (M1-5) on the human hypopharyngeal carcinoma FaDu cells. We found that the compound (M3) possesses a significant anticancer feature against FaDu cells that might be evaluated with further in vitro and in vivo studies to understand its anticancer potential better. Lastly, comparisons were made using molecular docking calculations to find the theoretical activities of the compounds (M1-5). The docking score parameter of the compound (M3) against the 2DO4 protein is −5.67, the docking score parameter against the 5JPZ protein is −5.72, and finally, the docking score parameter against the 2H80 protein is −5.50. Molecular dynamic calculations are made for 0–100 ns. The ADME/T calculations were performed to find the drug potential of the compounds (M1-5). The results suggest that our drug candidate compound exhibits strong potential for co-administration with the antigen structures, owing to the low rate of interactions that decreased over time. Communicated by Ramaswamy H. Sarma
Parton Dynamics in Forward Jet Events from Positron-Proton Collisions at HERA
Creators: name: Mackeprang, Rasmus
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2003

description: University of Copenhagen- Niels Bohr Institute, Masterarbeit, 2003; 116 pp., (2003).
Supplementary_data – Supplemental material for Moderating polarised positions on questions of national identity and sovereignty: Deliberative surveys on federalism in Myanmar
Creators: name: Breen, Michael G
name: Baogang He
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 200299 Cultural Studies not elsewhere classified
subject: FOS: Other humanities
subject: Economics
subject: 160607 International Relations
subject: FOS: Political science
subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, Supplementary_data for Moderating polarised positions on questions of national identity and sovereignty: Deliberative surveys on federalism in Myanmar by Michael G Breen and Baogang He in International Area Studies Review
Viro-immunotherapy for Triple Negative Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer with the poorest prognosis. Chemotherapy is used for the treatment of patients with metastatic TNBC. However, patients often develop resistance to chemotherapies and recurrence of cancer is common after initial response. Hence, there is an urgent need for improved therapies. We believe that an optimal therapeutic should not only eradicate tumors but also prevent tumor recurrence. Immunotherapy has shown unprecedented long-lasting efficacy in several types of malignancies. Therefore, we propose to study a novel therapeutic approach called “viro-immunotherapy”, which is a combination of two novel therapeutic approaches: Oncolytic virotherapy and Immunotherapy. Oncolytic viruses are live viruses “tamed” to replicate in and kill cancer cells while leaving normal cells unharmed. We have generated an artificial oncolytic poxvirus (CF33) that is very potent in killing breast cancer cells. This virus can further be armed with immune-stimulatory genes to act as immunotherapy for better treatment ofTNBC. Central hypotheses: We hypothesize that a chimeric poxvirus (CF33) can be engineered to selectively replicate in and kill triple negative breast cancer cells. Furthermore, the virus can be modified to produce two immune-stimulatory proteins, LIGHT and IL-15, which can further increase anti-tumor effectiveness of the virus by provoking anti-tumor immune response. Finally, virally produced immune-stimulatory proteins will prevent the cancer from recurrence by long-term maintenance of cancer-specific memory immune cells. The general methodology: We have already created a potent oncolytic poxvirus (CF33) that can kill triple negative breast cancer cells. We have also armed this virus with the immune-stimulatory genes LIGHT and IL-15 (CF33-LIGHT-IL-15). We will explore safety and anti-tumor efficacy of CF33-LIGHT-IL-15 in mouse models. Innovative elements and potential impacts: The main innovation of this project is the development of a next-generation immuno-oncolytic virus that combines the direct cancer killing ability of a chimeric poxvirus with enhancement of anti-tumor immunity through immune-stimulatory proteins produced by the virus. Our innovative project has the potential of developing a novel therapeutic for improved treatment, with less resistance and recurrence, ofTNBC.
Cris:Nrw - Landesinitiative Zur Umsetzung Des Kerndatensatz Forschung
Creators: name: Dr. Malte Kramer
Publisher: name: Zenodo
Year: 2017

description: Der Vortrag zeigt am Beispiel einer Initiative aus Nordrhein-Westfalen die Mehrwerte zentraler Kommunikations-und Unterstützungsstrukturen für die Implementierung des Kerndatensatz Forschung sowie die Schaffung zentraler Beratungsstrukturen für die Einführung von Forschungsinformationssystemlösungen.
Peer navigation for African American women during the breast cancer peri-diagnostic period
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: African American women are just as likely to be diagnosed with breast cancer as non-Hispanic white women but their mortality rate is 40% higher. This disparity is the result of a complex set of biologic and non-biologic factors that include delays in diagnosis and treatment as well as socioeconomic and psychosocial factors. Community-identified and community-driven approaches to address this disparity that can be easily implemented and scaled are urgently needed. A community-university partnership between Black Ladies Advocating for Cancer Care (BLACC) Peer Navigators and the Stanford Office of Community Engagement has come together to address this disparity by focusing on peer navigation for African American women. Peer navigation has been identified as a promising strategy to address breast cancer disparities and improve outcomes by addressing barriers to quality cancer care and providing comprehensive social support. Several critical gaps in research limit the implementation of peer navigation to address disparities faced by African American women. First, peer navigation programs that have been tested vary widely in terms of who serves as peer navigators, how they are trained, and what services are provided. Second, there have been very few peer navigation programs that were developed by and for African American women. Third, research designs have been limited to primarily retrospective and observational approaches as opposed to more rigorous designs such as randomized controlled trials. This project will address these research gaps through 3 aims. First, we will use a community-based participatory research orientation to strengthen and sustain a community-university partnership focused on improving breast cancer outcomes among African American women in California. Second, we will use storytelling with breast cancer survivors to examine the clinical and non-clinical needs and assets of African American women during the breast cancer peri-diagnostic period. Third, using data from breast cancer survivors and models of existing peer navigation programs, we will co-create a peer navigation program for the peri-diagnostic period for African American women.
Supplemental material for Trade connections’ effect on European regions’ interest in Brexit
Creators: name: Urbatsch, Robert
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography

description: Supplemental Material for Trade connections’ effect on European regions’ interest in Brexit by Robert Urbatsch in European Union Politics
Additional file 1 of Novel Organism Verification and Analysis (NOVA) study: identification of 35 clinical isolates representing potentially novel bacterial taxa using a pipeline based on whole genome sequencing
Creators: name: Muigg, Veronika
name: Seth-Smith, Helena M.B.
name: Adam, Kai-Manuel
name: Weisser, Maja
name: Hinić, Vladimira
name: Blaich, Annette
name: Roloff, Tim
name: Heininger, Ulrich
name: Schmid, Hanna
name: Kohler, Maurus
name: Graf, Lukas
name: Winterflood, Dylan M.
name: Schlaepfer, Pascal
name: Goldenberger, Daniel
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1: Supplemental material is available online only. Supplemental Table S1.
Peripheralisation: The Missing Link in Dealing with Demographic Change?
Creators: name: Leibert, Tim
name: Golinski, Sophie
Publisher: name: Federal Institute for Population Research
Year: 2017
Subjects: Peripheralisation; Demographic change; Adaptation strategies; Public services; East Germany

description: Demographic change is an uneven spatial process in Germany. Depopulation and ageing have become pressing issues in most rural regions. In connection with low population densities and the financial difficulties of municipalities and service providers in rural regions, these demographic trends have led to a discussion about the future provision of services of general interest and – more broadly – the postulate of equal living conditions which was for a long time the basic principle of spatial development in Germany. In this paper, we argue that the peripheralisation approach is a helpful tool to better understand how interaction of out-migration, dependence, disconnection and stigmatisation shape the future of rural regions. We also discuss the impact of peripheralisation on the development and implementation of adaptation strategies. Based on the 3R-model (retrenchment, repositioning, reorganisation), we argue that adaptation strategies can reinforce (retrenchment) peripheralisation processes, but also serve as groundwork for the formulation of policies aiming at de-peripheralisation.
description: Comparative Population Studies, Vol 41, No 3-4 (2016): Geographies of Demographic Change: Theories and Narratives
Thirdhand Smoke Biomarkers Analytical Chemistry Laboratory
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: This subproject is part of a consortium of California researchers who are seeking to understand the risks of exposure to aged secondhand smoke, which has been termed "thirdhand smoke" (THS). Past studies have shown that secondhand smoke becomes more toxic as it ages. It is particularly concernful that levels of potent cancer-causing substances (carcinogens) called tobacco-specific nitrosamines (TSNAs) increase as smoke ages. Studies carried out by this consortium have identified numerous toxic substances in THS, and that many of them persist in homes and other places for long periods after smoking has ceased. This third phase of the Consortium will focus on studies that are "translational" in nature, using the information from previous basic science studies, and applying this knowledge to studies that relate more directly to human health issues, and to remediation (detoxification) of THS contaminated homes, automobiles, and other places contaminated by THS. The researchers in this subproject are chemists who have been studying human exposure to toxic substances in tobacco smoke for many years. For this subproject they will continue to develop methods for measuring human exposure to toxic substances in THS, needed to augment those developed in the past. To assist in achieving the goals of the Consortium, they will analyze samples from studies carried out by researchers in other subprojects that will assess the toxicity of THS, and analyze samples from other subprojects to measure human exposure in real-world settings. These studies will expand our knowledge about the chemical nature of THS and its impact on public health. It is expected that the research carried out by this consortium will be useful in developing policies for protecting people from THS exposure, and will help in developing methods for detoxifying places contaminated by THS.
DS_DISC874313 – Supplemental material for Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK–Paxillin Interaction
Creators: name: Marlowe, Timothy
name: Alvarado, Carlos
name: Rivera, Andrew
name: Lenzo, Felicia
name: Nott, Rohini
name: Bondugji, Dena
name: Montoya, Justin
name: Hurley, Alana
name: Kaplan, Matt
name: Capaldi, Andrew
name: Cance, William
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, DS_DISC874313 for Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK–Paxillin Interaction by Timothy Marlowe, Carlos Alvarado, Andrew Rivera, Felicia Lenzo, Rohini Nott, Dena Bondugji, Justin Montoya, Alana Hurley, Matt Kaplan, Andrew Capaldi and William Cance in SLAS Discovery
title: Tissue and Organ Transplantation: Ethical and Economical Considerations in Different Health Systems
Creators: name: Guthoff, Rudolf
Publisher: name: MyCoRe Community
Year: 2024
Subjects: subject: Transplantation
subject: Ethics
subject: Ethik
subject: Economy
subject: Health System
subject: Öffentliches Gesundheitswesen
subject: 610

description: After spending a whole day learning about the latest developments in the field of transplant medicine, our so-called “standby knowledge” was expanded to include many important facts. Nevertheless, we know that we will need another update in a year or two, because the half-life of knowledge of this kind is short. I was given the task of talking about ethical and economical aspects that may be addressed as elements of “oriental knowledge”. This is about rules and considerations that have been known for hundreds of years and have a long half-life. To start with some rules given by Galileo Galilei: (1.) Measure what is measurable. (2.) Make measurable what cannot be measured. How to deal with the remaining non-measurable elements of medicine? Which currency can be used? We know that we cannot use the same currency. Options are charity, reputation and others. How do you deal with objects of cultural value? What justifies breaking taboos? There are societies in which reason dominates, and others in which emotions and ideas are not controlled by our Western type of reason. “Each society generates that kind of medicine which it deserves” (Giovanni Maio). How do we deal with this statement in the world of globalization? It sounds rigorous, with its connotation of harsh being inhuman or even brutal. The German word “verdienen” means also making money, earning a living, which brings us back to Galilei’s claim “make it measurable”. Since we added “find a suitable currency to make it practical”, the loop is closed and no simple practical solution has been found. Societies differ in terms of wealth and self-understanding and their willingness to prioritize something like transplant medicine in their health politics. Examples from the field of corneal allocation and transplantation in the United States, Japan, the Democratic Republic of Congo, and Germany show that there are major differences, especially in donation strategies. For the kidney field, the “Alliance for Paired Donation” an initiative by Alvin Roth et al. is briefly presented. In this context, Max Weber’s terms “Gesinnungsethik” (ethics of attitude) and “Verantwortungsethik” (ethics of responsibility) are discussed.
description: Transplantation: Ethics, Techniques, Immunology, p. 109
Stemness suppressors to combat aggressive breast cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Smoking is linked to an increased risk of developing aggressive breast cancer. While metastasis is the leading-cause of breast cancer-related deaths, there are still no effective ways of preventing this disease. This is all the more frustrating since many metastases form months or even several years after initial surgery or chemotherapy as recurrent disease. While breast cancer subtypes are useful predictors of the response to therapy they do not adequately identify a tumor’s metastatic potential. My work on normal mammary stem cells important for remodeling the breast during pregnancy led to my recent discovery of a new cancer stem cell (CSC) population associated with aggressive disease in multiple clinical subtypes. This suggests that these cells are important biomarkers of breast cancers likely to progress and potential targets for drug therapy. Importantly, I have identified a key cell survival pathway that, when reversed, may represent a critical vulnerability of these CSCs. Thus, my proposal will test the hypothesis that blocking this pathway represents an Achilles heel for CSCs that will prevent recurrence and metastasis regardless of breast cancer subtype. If successful, my studies would represent an important breakthrough toward the goal of reducing deaths from breast cancer. My approach will incorporate not only more expedient cell lines, but also state-of-the-art patient-derived tumor models in which to test my therapies in cancers that better reflect patient disease, including estrogen receptor-positive (ER+) and triple-negative subtypes. By investigating my therapy in recurrence models post-chemotherapy, I will go the extra mile in attempting to prevent metastasis in a setting that mirrors what patients often experience. Importantly, I plan to re-purpose pre-existing drugs, already approved for use in patients, thereby accelerating the potential for translating successful outcomes from these studies into the clinic. By focusing on eliminating CSCs, my proposed studies represent a sea change in how breast cancer therapies are identified and tested in the laboratory. My unique approach may provide a much-needed means of preventing recurrence and metastasis and reducing mortality in a broad-spectrum of patient breast cancers.
Additional file 1 of A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women
Creators: name: Razmpoosh, Elham
name: Safi, Sara
name: Mazaheri, Mahta
name: Khalesi, Saman
name: Nazari, Majid
name: Mirmiran, Parvin
name: Nadjarzadeh, Azadeh
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Computational Biology

description: Additional file 1
Social Cognition in Relation to Tobacco Craving and Inflammation in HIV
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: People with HIV infection are more twice as likely to smoke cigarettes than people who do not have HIV. This high rate of smoking continues even though people with HIV are more susceptible to the negative effects of tobacco, including greater risk for conditions such as cancer, as well as cardiovascular and lung diseases. Importantly, smokers living with HIV (SLWH) say that they are less motivated to quit because smoking helps them control their emotions and many people in their social networks are smokers, which could lead to negative social consequences if they did quit. In contrast, having clear information about the specific effects of smoking in the context of HIV disease was noted to be a powerful motivator to quit. Given this background, investigating the social-emotional abilities that support social interaction, which is known as “social cognition,” in SLWH may identify problems that would be key areas to target in treatments for quitting smoking to enhance their success. In support of that idea, one type of social cognition problem, poor ability to identify and describe one’s feelings, has been linked to increased tobacco craving. Problems with other kinds of social cognition, including accurately reading the emotions and intentions of other people, have yet to be studied in relation to tobacco craving but have been linked to worse severity of addiction to alcohol and stimulants, suggesting they may be relevant in tobacco use as well. Also, both HIV and smoking can affect inflammation, which then contributes to multiple poor health outcomes. Social-emotional distress is related to higher inflammation; however, the exact nature of this relationship remains unknown in SLWH. Therefore, this pilot proposal will examine social cognition in a group of people with and without HIV, half of whom will be current smokers. Social cognition will be assessed, and it is hypothesized that SLWH will have worse performance. This poor performance will be related to increased tobacco craving in the smokers, and this relationship will be stronger in SLWH. Markers of inflammation and the conditions that contribute to inflammation will be explored in blood samples. The goal of this study is to use the knowledge gained to tailor smoking cessation interventions for SLWH in ways that address their own stated needs.
title: Speech Feature Computation for Visual Speech Articulation Training
Creators: name: Auberg, Stefan
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1996

description: A new version of the Visual Speech Articulation Training Aid was implemented which provides real-time visual feedback for speech articulation training. This version was migrated to a Windows Multimedia PC from a previous version which used a Personal Computer (PC) system and additional specialized and expensive custom hardware. This new version will make the system more available to schools and private users. A new method was developed for computing spectral/temporal features which characterize the speech sounds. In addition to the typical frame-based spectral analysis parameters, the new method represents temporal changes of the spectrum with a small number of features. The flexible method implemented can easily be adapted to compute features for a wide range of speech processing tasks. Linguistically-based distinctive features were also investigated as candidate features for the visual display system. Some experimental results are given for vowels using the new system.
Additional file 2 of A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women
Creators: name: Razmpoosh, Elham
name: Safi, Sara
name: Mazaheri, Mahta
name: Khalesi, Saman
name: Nazari, Majid
name: Mirmiran, Parvin
name: Nadjarzadeh, Azadeh
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Computational Biology

description: Additional file 2
Control of the Hedgehog pathway by cilium proteins
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Mutations in the Hedgehog (Hh) signaling pathway leads to various birth defects and tumor formation, including medulloblastoma, a malignant pediatric brain tumor. The transduction of the Hh signaling relies on the primary cilium, a tiny cell surface organelle that functions as the hub of cell signaling. To reveal new cilium proteins related to the Hh pathway, we have conducted a proximity-based proteomic studies, and uncovered novel cilium proteins. In this proposal, we will focus on one of the novel cilium proteins, Numb, to reveal its regulatory mechanism in the Hh pathway and the Hh-related tumor growth. Previous studies on Numb implicate this protein in asymmetric cell division and regulation of multiple signaling pathways. However, the molecular mechanism of how Numb participates in these cellular processes remains controversial. Our discovery of Numb’s localization in the primary cilium may help elucidate the unknown mechanisms. We found that Numb loss of function leads to accumulation of a Hh transcription regulator, Gli3 repressor (Gli3R). For Hh pathway to be turned on, the Gli3R has to be degraded. Numb has been described as an adaptor protein that links target proteins to the E3 ligase, Itch. Therefore, we hypothesize that Numb is required to switch on the Hh signaling by degrading Gli3R. We will test this hypothesis via the following Aims: 1) Determine roles of Numb as an adaptor of ubiquitin ligase for Gli3R; 2) Identify roles of Numb in the proliferation and differentiation of granule neuron precursors in the developing cerebellum; 3) Determine roles of Numb in the formation of medulloblastoma in mouse models. Our results will elucidate a new regulatory mechanism of the Hh pathway and Hh-related tumor formation.
Community Driven Intervention Development for Young Black Women who have experienced cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Partnering with The GREEN Foundation, this project aims to address the unique breast health needs of young Black women cancer survivors in Southern California. Despite significant progress in cancer care, young Black women face distinct barriers to accessing breast health services and essential resources, leading to unmet needs within this population. This project will bring together advocates, researchers, and community members to collaboratively identify these barriers and design culturally responsive solutions that improve access, support, and overall quality of care. Our first objective is to conduct a comprehensive review of existing data from community health advocates, healthcare providers, and community members, identifying key obstacles that impact breast health access in Southern California. We will also examine The GREEN Foundation’s current referral practices through interviews with staff, volunteers, survivors, and their families, providing a broader understanding of how technology might enhance resource connections and ease barriers to care. To ensure community engagement and project alignment, we will host monthly planning meetings with The GREEN Foundation, local advocates, healthcare partners, and community agencies. These meetings will allow us to gather ongoing feedback and make iterative adjustments based on community priorities, creating a project that genuinely reflects the needs of those it aims to support. Furthermore, monthly co-design workshops will be facilitated with survivors and their families to develop a gender-sensitive, culturally relevant socio-technical solution. These workshops will empower participants to contribute to a project that is tailored to the distinct needs of marginalized groups in Southern California, ensuring that the final design directly addresses the challenges they face. The insights from these activities will be synthesized into a detailed report, which will inform a grant proposal dedicated to advancing tailored interventions for young adult cancer survivors in underserved communities. By combining community insights, research expertise, and collaborative design, this project seeks to create sustainable, impactful improvements in breast health access and care for young Black women, with a vision to enhance health equity and long-term outcomes within this community.
“Election benchmarks” as an instrument to exert political influence for the benefit of archaeology — an opinion piece / „Wahlprüfsteine” als Instrument politischer Einflussnahme für die Archäologie – ein Meinungsbeitrag
Creators: name: Siegmund, Frank
name: Scherzler, Diane
name: Schön, Werner
Publisher: name: Archäologische Informationen
Year: 2024

description: Der Beitrag stellt ein politisches Ritual namens „Wahlprüfsteine“ vor, mit dessen Hilfe NGOs und Interessenvertreter im Vorfeld einer Wahl die Positionen und Pläne der zur Wahl stehenden politischen Parteien ausloten. Die Parteiantworten werden gesammelt und vor der Wahl den Wählern bekannt gemacht, damit sie in ihre Wahlentscheidung einfließen können. Die mit dem Verfahren gewonnenen Selbstfestlegung(en) der künftigen Regierungspartei(en) können später verwendet werden, um das Einhalten von Wahlversprechen anzumahnen. Neben dem erhofften direkten Nutzen des Verfahrens werden indirekte Effekte erzielt, auch solche, die in die Archäologie und ihre Selbstorganisation zurückwirken.
description: Archäologische Informationen, Bd. 46 (2023): Archäologische Informationen
On the French constitutional imaginary: The erosion of the long-standing Republican tradition
Creators: name: Millet, François-Xavier
Publisher: name: Zenodo
Year: 2023

description: The French imaginary is a Republican imaginary that is premised on political liberty. The red thread across the political thought and the various constitutions of France has been the pursuit of the ideal political regime that would best realise political liberty and the general interest. That approach stands in stark contrast with the civil-liberty-focused Anglo-Saxon liberal tradition according to which state power ought to be curtailed in order to maximise individual rights. Those two essentially different traditions could rather peacefully coexist at the Westphalian time of the nation-states. The clash has however become inevitable in a time where globalisation and the latter’s regional avatars, such as the European Union, act as vehicles of Anglo-Saxon liberalism. This paper introduces to the French constitutional imaginary relying on the tools provided by intellectual history and constitutional law. It contrasts it with the Anglo-Saxon political thought and shows how the former remains strong despite the erosion caused by the pervasiveness of the latter.
UCLA CHPR CRC Planning Grant
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The UCLA Center for Health Policy Research has a strong history of studying service needs for women with breast cancer, including patient navigation services. Patient navigation services help patients manage appointments, understand treatments and insurance benefits, and access support. For this new project, UCLA will partner with Cancer Kinship, a community organization in Southern California that provides support services to cancer patients. Cancer Kinship has extensive experience working with cancer patients in a community setting and collaborating with other community groups. We will also work with researchers from UC-Irvine who specialize in cancer care interventions. The overall goal of this project is to plan and develop a proposal to create a model for cancer patients to navigate care, designed for community organizations to use. Unlike hospital or insurance-based navigation programs, this model will be tailored specifically for community groups working with culturally diverse populations. During the 12-month planning phase, the team will review the literature for current practices in patient navigation among community-based organizations that work with diverse communities. We will design a research approach intended to identify what patients most need from navigation services and what community-based groups can provide most effectively. The results will inform a model for navigation services that community groups can use. The model will include strategies for adapting the services to address cultural differences and needs of the communities served. Over the course of 12 months, our team from UCLA, Cancer Kinship and UC Irvine will work together on several key tasks. We will: (1) review existing models of patient navigation services to identify best practices; (2) identify additional community partners that serve that serve diverse communities; (3) identify information gaps about what patients most need from navigation services; (4) develop a project timeline; and (5) write a draft proposal. At the end of the planning period, we will have a proposal describing a project that would develop and test the feasibility of a community-based patient navigation model that will help community organizations provide culturally responsive care for cancer patients.
Additional file 1 of Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets
Creators: name: Huang, Wei-Chieh
name: Jayakumar, Thanasekaran
name: Sheu, Joen-Rong
name: Hsia, Chih-Wei
name: Hsia, Chih-Hsuan
name: Yen, Ting-Lin
name: Chang, Chao-Chien
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Effects of glabridin on cytotoxicity in human platelets. Washed human platelets were pretreated with either the solvent controlor glabridinfor 20 min, and a 10 μL of the supernatant was dropped on a Fuji Dri-Chem slide LDH-PIII. Data are presented as the mean ± standard error of the mean. Figure S2. Inhibitory profiles of glabridin for IKK, p65, Lyn and integrin β3 activation stimulated by collagen in human platelets. Washed platelets were preincubated with a solvent controlor glabridin, followed by the addition of collagento stimulateIKK,p65,Lyn, andintegrin β3 phosphorylation.
Supplemental material for Speech Perception: Phonological Neighborhood Effects on Word Recognition Persist Despite Semantic Sentence Context
Creators: name: Cervera-Crespo, Teresa
name: González-Álvarez, Julio
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material for Speech Perception: Phonological Neighborhood Effects on Word Recognition Persist Despite Semantic Sentence Context by Teresa Cervera-Crespo and Julio González-Álvarez in Perceptual and Motor Skills
Supplemental_material - Testing epistemic democracy’s claims for majority rule
Creators: name: Berger, William J
name: Sales, Adam
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental_material for Testing epistemic democracy’s claims for majority rule by William J Berger and Adam Sales in Politics, Philosophy & Economics
Supplemental material for Left ventricular peak early diastolic strain rate detected by two-dimensional speckle tracking echocardiography and disease severity in pre-capillary pulmonary hypertension
Creators: name: Liu, Bing-yang
name: Wu, Wei-chun
name: Zeng, Qi-xian
name: Liu, Zhi-hong
name: Niu, Li-li
name: Tian, Yue
name: Cheng, Xiao-ling
name: Luo, Qin
name: Zhao, Zhi-hui
name: An, Chen-hong
name: Huang, Li
name: Wang, Hao
name: He, Jian-guo
name: Xiong, Chang-ming
Publisher: name: SAGE Journals
Year: 2019
Subjects: Cardiology
Respiratory Diseases

description: Supplemental Material for Left ventricular peak early diastolic strain rate detected by two-dimensional speckle tracking echocardiography and disease severity in pre-capillary pulmonary hypertension by Bing-yang Liu, Wei-chun Wu, Qi-xian Zeng, Zhi-hong Liu, Li-li Niu, Yue Tian, Xiao-ling Cheng, Qin Luo, Zhi-hui Zhao, Li Huang, Hao Wang, Jian-guo He and Chang-ming Xiong in Pulmonary Circulation
RISE UP for Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: RISE UP (Revolutionizing Investigations to StEp Up Prevention) is a second annual conference that leverages what we know about breast cancer biology, treatment, and hormonal management to better approach breast cancer prevention and more effective and tolerable agents for breast cancer patients and survivors. RISE UP was conceptualized in 2023 by Dr. Laura Esserman. In 2024, RISE UP attracted over 300 attendees across a variety of disciplines. This wealth of expertise was applied to three focus areas: 1) new drugs and treatments that can be used on tumors that are found early; 2) using imaging and other methods to find early indicators of breast cancer; 3) highlight important research about the biology of breast cancer and of the hormonal cycle control in women. As our understanding of breast cancer and hormonal management improves, we should use this knowledge to upgrade the hormonal control products that millions of women take over the course of their lifetime with a goal of reducing breast cancer incidence. In the second year, we will build upon the progress and research presented, continuing to push the field forward. RISE UP consists of poster sessions to highlight research and a series of speaker and discussion sessions. The conference is designed to foster questions, collaborations, and generation of new ideas about breast cancer and to generate data on new hormonal products that have the potential for breast cancer risk reduction. RISE UP will continue to ensure accessibility to advocates and students and those who are underrepresented in their field. The conference will be held over several days in fall 2025 in SF. We are especially excited about this location for the event and hope that the entrepreneurial spirit of Silicon Valley will energize attendees to challenge the status quo and take action. We will build the notion of idea to implementation into the conference: we will hold a competition for the best idea for incorporating breast cancer prevention into the hormone-based OB/GYN care women already receive-- and a prize of working with biotech and investment leaders from across the US to make that idea a reality. In 2024, we received 18 submissions and raised $200,000 for innovative ideas to incorporate breast cancer risk-reduction into commonly used hormonal products.
AI-Driven Advancements in Mammography: Assessing Efficiency and Burnout to Enhance Patient Care
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: In California we often have six month wait times to schedule a mammogram along with a growing shortage of radiologists to interpret mammograms and rising radiologist burnout. Most mammograms are now three-dimentional (3D) tomography exams, which have more than 50 pictures of each breast instead of just a single two-dimentional picture. These 3D exams require longer interpretation times, leading to further exhaustion for radiologists, longer patient wait times, delays in breast cancer diagnoses, and poor quality of care. While artificial intelligence tools may improve accuracy, its impact on interpretation time and radiologists' well-being remains unknown. We will conduct a two-year randomized clinical trial on the impact of artificial intelligence on screening mammography accuracy involving over 90,000 exams at UCLA Health. We will assess whether artificial intelligence will catch cancers missed by radiologists and reduce false positives. During the trial radiologists will interpret half of the images with and half without artificial intelligence support. For this California Breast Cancer Research Program award, we propose adding new data collection during the trial to allow us to study the concurrent impact of artificial intelligence on efficiency and wait times. We aim to determine if artificial intelligence helps radiologists interpret mammograms faster without compromising accuracy and if it can reduce their fatigue and burnout. We will begin by consulting UCLA breast radiologists and surveying California practitioners to get their perspectives on artificial intelligence tools. Collaborating with patient advocates, we'll ensure the survey captures patient-centric concerns. We will also track interpretation time during the trial, allowing us to evaluate efficiency along with accuracy, while post-trial discussions will provide insight into radiologists' experiences. Our study will offer new insights into integrating artificial intelligence tools into breast cancer screening, informing real-world practice. By understanding artificial intelligence’s impact on efficiency and burnout, we aim to optimize its implementation statewide, empowering radiologists to focus on complex cases, patient care, and diverse communities. This pioneering research promises more effective and patient-centered breast cancer screening practices in California and beyond.
Policy priorities for equitable access to fertility preservation by breast cancer patients
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The goal of the project is to gather evidence on oncofertility care of young breast cancer patients in California and summarize the evidence to inform policymaking. One in ten breast cancer patients is of reproductive age when they are diagnosed. Young breast cancer patients are at risk of infertility from cancer treatments due to direct ovarian toxicity from alkylating and platinating chemotherapy, sterilization from removing ovaries, and/or reproductive aging during prolonged time on hormone therapy. Fertility preservation before breast cancer treatment can decrease infertility risks. Patients want to learn about their risks, engage in shared decision-making on fertility preservation, and do fertility preservation when appropriate. Oncofertility care involves educating patients about reproductive risks and fertility preservation and providing access to fertility preservation services. Because oncofertility care doesn’t reach many patients, many policies from state laws like Senate Bill 600 that require health insurance plans to cover fertility preservation to fertility clinic policies to facilitate care have been enacted, but we lack a summary of policies and their effectiveness in promoting delivery of oncofertility care. Thus, we lack the evidence to make sound policies in this area. The investigator team has complementary clinical, policy, research, and advocacy expertise in oncofertility care and a history of working together. They will convene an Advisory Panel of researchers, leaders, decision makers, and community groups to undertake this work. They will complete rapid reviews of published and public data. They will hold a Symposium to hear from stakeholders, present data and experiences, and workshop ideas on key evidence and policy recommendations. The investigators and Advisory Panel will generate summaries of their findings and evidence-based policy recommendations for dissemination. The team will then support dissemination of project deliverables to promote the equitable delivery of oncofertility care to young breast cancer patients in California.