cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
General PFG signal attenuation expressions for anisotropic anomalous diffusion by modified-Bloch equations
Creators: name: Lin, Guoxing
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Anomalous diffusion exists widely in polymer and biological systems. Pulsed-field gradient (PFG) anomalous diffusion is complicated, especially in the anisotropic case where limited research has been reported. An general PFG signal attenuation expression, including the finite gradient pulse (FGPW) effect for free general anisotropic fractional diffusion based on the fractional derivative, has not been obtained, where α and \b{eta} are time and space derivative orders. It is essential to derive a general PFG signal attenuation expression including the FGPW effect for PFG anisotropic anomalous diffusion research. In this paper, two recently developed modified-Bloch equations, the fractal differential modified-Bloch equation and the fractional integral modified-Bloch equation, were extended to obtain general PFG signal attenuation expressions for anisotropic anomalous diffusion. Various cases of PFG anisotropic anomalous diffusion were investigated, including coupled and uncoupled anisotropic anomalous diffusion. The continuous-time random walk (CTRW) simulation was also carried out to support the theoretical results. There is good agreement between the theory and the CTRW simulation. The obtained signal attenuation expressions and the three-dimensional fractional modified-Bloch equations are important for analyzing PFG anisotropic anomalous diffusion in NMR and MRI.
description: 25 pages,6 figures
Additional file 6: Figure S6. of Systematic comparison of small RNA library preparation protocols for next-generation sequencing
Creators: name: Cloelia Dard-Dascot
name: Naquin, Delphine
name: DâAubenton-Carafa, Yves
name: Alix, Karine
name: Thermes, Claude
name: Dijk, Erwin Van
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Quantitative detection of oilseed rape miRNAs using protocols TS7, Nf2, and Nf6. Libraries were preparing from B. napus small RNA preparation originating either from floral buds or from stems and leaves and miRNA expression changes were measured. The detected fold changes with the different protocols were compared to each other and the coefficients of determination (R2) were calculated. (PDF 1.01 mb)
Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency
Creators: name: Franciosi, Alessandro
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Alpha-1 antitrypsin deficiency (AATD) is characterised by deficiency of AAT, the primary inhibitor of serine proteases, resulting in an increased risk of COPD. The wild-type allele which encodes for normal AAT is the Pi*M variant, most commonly inherited in homozygosity (genotype MM). The most prevalent deficiency-causing AAT mutations are the Pi*S and Pi*Z alleles which can be inherited in co-dominance with Pi*M or other deficient alleles. The severe form ZZ-AATD, is associated with COPD regardless of smoking and is characterised by very low AAT levels in serum. Moreover, inheritance of a single deficient Pi*Z allele for AAT (MZ-AATD) has also been shown to increase the risk of COPD in smokers but not non-smokers. The SZ genotype is considered a high-risk genotype despite a lack of conclusive evidence. The aim of this study was to clarify the effect of the SZ genotype on lung health. Clinical data from MZ, SZ and ZZ participants in the National AATD Registry was compared, demonstrating that SZ-AATD is more akin to the moderately deficient MZ-AATD than severe ZZ-AATD. Subsequently, a family study was performed, comparing lung function and symptoms between SZ individuals and controls. SZ-AATD demonstrated significantly worse lung function among ever-smokers but not never smokers. Furthermore, within the SZ cohort AAT levels were not found to predict outcomes. The effect of smoking cessation in SZ-AATD was quantified by comparing never- and former-smokers, demonstrating no significant difference in lung function decline or anti-protease capacity. Finally, AAT deficient individuals on the National AATD Registry were surveyed to determine the factors affecting their smoking habits. Parental smoking was found to significantly increase the risk of being an ever-smoker and that severity of AATD affects disease-insight and the likelihood of being a former-smoker, suggesting that AATD individuals are at risk of inheriting both a genetic substrate for lung disease and an environmental catalyst (smoking) from their parents. Collectively these results indicate that SZ-AATD is not an independent driver of COPD and that AAT levels should not be used as an indication for treatment, strongly suggesting AAT augmentation is not indicated in this genotype. Summarily, these findings represent a paradigm shift in the field of AATD.
Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D’Arcy
Creators: name: Almeida, Alisson A.
name: Cota, Betania B.
name: Rodrigues, Laís M.
name: Dutra, Luana L.
name: Kohlhoff, Markus
name: Bressan, Gustavo C.
name: Brandão, Geraldo C.
name: Leite, João P. V.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Cancer
subject: Plant Biology

description: Bioassay-guided fractionation of dichloromethane extract from Athenaea velutina leaves led to the isolation of three withanolides, all being reported for the first time in this species. They were identified as withacnistin (1), withacnistin acetate (2) and a new withanolide, designated as withalutin (3). The structures were established by spectral data analysis, including MS, 1D and 2D NMR. In addition, in silico ADMET studies were employed to understand the pharmacokinetic properties of these withanolides. The withanolides isolated from A. velutina reduced cancer cell viability with IC50 values ranging from 1.52 to 5.39 µM. In silico prediction revealed that withanolides have good gastrointestinal absorption or oral bioavailability properties; and are not likely to be mutagenic or hepatotoxic. These findings revealed that A. velutina is an important source of cytotoxic withanolides.
title: 01_2287
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 2: of Sustainable reduction of antibiotic-induced antimicrobial resistance (ARena) in German ambulatory care: study protocol of a cluster randomised trial
Creators: name: Kamradt, Martina
name: Kaufmann-Kolle, Petra
name: Andres, Edith
name: Brand, Tonia
name: Klingenberg, Anja
name: Glassen, Katharina
name: PoĂ-Doering, Regina
name: Uhlmann, Lorenz
name: Hees, Katharina
name: Weber, Dorothea
name: Gutscher, Andreas
name: Wambach, Veit
name: Szecsenyi, Joachim
name: Wensing, Michel
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Eligible medical specialist groups for participation in the ARena study (Table S1); description of the recruitment of participants in the ARena study (Table S2). (PDF 222Â kb)
Signs of the time: Melonic theories over diverse number systems
Creators: name: Gubser, Steven S.
name: Heydeman, Matthew
name: Jepsen, Christian
name: Parikh, Sarthak
name: Saberi, Ingmar
name: Stoica, Bogdan
name: Trundy, Brian
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Melonic field theories are defined over the $p$-adic numbers with the help of a sign character. Our construction works over the reals as well as the $p$-adics, and it includes the fermionic and bosonic Klebanov-Tarnopolsky models as special cases; depending on the sign character, the symmetry group of the field theory can be either orthogonal or symplectic. Analysis of the Schwinger-Dyson equation for the two-point function in the leading melonic limit shows that power law scaling behavior in the infrared arises for fermionic theories when the sign character is non-trivial, and for bosonic theories when the sign character is trivial. In certain cases, the Schwinger-Dyson equation can be solved exactly using a quartic polynomial equation, and the solution interpolates between the ultraviolet scaling controlled by the spectral parameter and the universal infrared scaling. As a by-product of our analysis, we see that melonic field theories defined over the real numbers can be modified by replacing the time derivative by a bilocal kinetic term with a continuously variable spectral parameter. The infrared scaling of the resulting two-point function is universal, independent of the spectral parameter of the ultraviolet theory.
description: 40 pages, 2 figures. v2: Small changes, references added
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00363
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00363, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Erigeron annuus flower absolute prolongs botulinum neurotoxin A-induced muscle paralysis and inhibits neurotransmitter release-linked responses
Creators: name: Hwang, Dae Il
name: Won, Kyung Jong
name: Kim, Do Yoon
name: Kim, Mi Jung
name: Won, Yu Lim
name: Kim, Nan Young
name: Kim, Young Geol
name: Kim, Bokyung
name: Lee, Hwan Myung
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer

description: This study aimed to determine the effects of Erigeron annuus (L.) Pers. (EAP) flower absolute (EAPFAb) on neurotransmitter release-blocking events and muscle paralysis induced by botulinum neurotoxin type A (BoNT/A). For this study, EAPFAb was extracted from EAP flowers by solvent extraction and its composition was determined by GC/MS. Neurotransmitter release and SNARE protein expression were examined in PC12 cells by ELISA and immunoblotting. Rat hind limbs were tested for muscle paralysis. EAPFAb contained 23 components and prolonged the duration of BoNT/A-induced rat hind limb muscle paralysis. EAPFAb reduced neurotransmitter release induced by elevated extracellular potassium levels and attenuated SNARE protein expression in PC12 cells. These findings demonstrate that EAPFAb prolongs BoNT/A-induced muscle paralysis action, probably by inhibiting releases of neurotransmitters that are regulated by SNARE proteins in neural cells. EAPFAb may be a promising material for prolonging BoNT/A action.
Additional file 5: Figure S2. of Adaptive genomic evolution of opsins reveals that early mammals flourished in nocturnal environments
Creators: name: Borges, Rui
name: Johnson, Warren
name: OâBrien, Stephen
name: CidĂĄlia Gomes
name: Heesy, Christopher
name: Antunes, Agostinho
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Phylogenetic character mapping for the ancestral reconstructions. Ancestral reconstructions of the activity pattern and sw1-sensitivity are represented in pie charts, each slice representing the probability of each state. Ancestral inferences of the orbit convergence (degrees) and visual acuity (cycles per degree) are represented by circles that change in size and shade of grey according to the character value. The opsin trees were estimated under the assumption of the branch-specific free-ratios model using the Meredith et al. (2011) tree topology. (PDF 1239Â kb)
title: 3D Cadastre
title: Design, Development, Standards, Modelling
titleType: AlternativeTitle
title: nD Κτηματολόγιο
title: Σχεδιασμός, Ανάπτυξη, Πρότυπα, Μοντελοποίηση
titleType: AlternativeTitle
Creators: name: Dimopoulou, Efterpi Magdalini
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: 3Δ ΚΤΗΜΑΤΟΛΟΓΙΟ
ΕΘΝΙΚΟ ΚΤΗΜΑΤΟΛΟΓΙΟ
ΕΙΔΙΚΑ ΙΔΙΟΚΤΗΣΙΑΚΑ ΑΝΤΙΚΕΜΕΝΑ
ΝΔ ΜΟΝΤΕΛΟΠΟΗΣΗ
ΔΙΕΘΝΗ ΠΡΟΤΥΠΑ
3D Cadastre
Hellenic Cadastre
Special Real Property Objects
ND Modeling
Prototypes
Ladm

description: Τα τελευταία χρόνια η διεθνής επιστημονική κοινότητα δείχνει ιδιαίτερο ενδιαφέρον στις τρισδιάστατες κτηματολογικές καταγραφές για την απεικόνιση της πολυπλοκότητας του σύγχρονου αστικού κυρίως τοπίου των επικαλυπτόμενων κατασκευών και των σύνθετων εμπράγματων δικαιωμάτων. Η στροφή προς την τρίτη διάσταση υποστηρίζεται σημαντικά από τις σημερινές τεχνολογικές εξελίξεις σε θέματα μοντελοποίησης, ενώ τελευταία, στον κτηματολογικό σχεδιασμό υπεισέρχεται η διάσταση του χρόνου αλλά και της κλίμακας. Η διεθνής εμπειρία, παρά τη δυναμική τεχνολογική της πρόοδο, δεν έχει να επιδείξει κανένα πλήρως λειτουργικό 3D κτηματολόγιο και περιορίζεται σε πειραματισμούς και βασικές εφαρμογές, ενώ το πεδίο της έρευνας στα 3D κτηματολογικά συστήματα οριοθετείται από το νομικό, τεχνικό και διοικητικό πλαίσιο κάθε χώρας, που συνεπάγεται συγκεκριμένες ανάγκες, περιορισμούς και δυνατότητες των 3D κτηματολογικών εγγραφών.
Στο πλαίσιο αυτό, αντικείμενο της πρότασης είναι η καταγραφή και αξιολόγηση των εξελίξεων σε θέματα 3D/nD μοντέλων και συστημάτων διαχείρισης βάσεων δεδομένων και κτηματολογικών καταγραφών, μέσα από την επισκόπηση της διεθνούς εμπειρίας. Παράλληλα παρουσιάζεται η κατάσταση στην Ελλάδα, μέσα από τις ιδιαιτερότητες και τις ανάγκες καταγραφής, διαχείρισης και απεικόνισης του 3D χώρου, με αναφορά στην πορεία και τα χαρακτηριστικά του έργου σύνταξης του Εθνικού Κτηματολογίου, στο ισχύον κτηματολογικό μοντέλο, αλλά και στις προοπτικές προσαρμογής του σε διεθνή πρότυπα και απαιτήσεις.
Lettre de Jean-François Nicolas à Jean-François Séguier, 1778-04-20
Creators: name: Nicolas, Jean-François
name: Jean-François Nicolas
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Physique (général)
Médecine

description: [transcription] à Grenoble le 20 avril 1778

Monsieur et très cher confrère

J'ai reçu par M. Brette les thèses que vous avez eu la bonté de m'envoyer, et le résultat de l'assemblée de la société royale. Je vous remercie de ce nouveau cadeau. J'ai lu surtout avec un grand plaisir, le mémoire sur la foudre ascendante et descendante: votre témoignage donne le poids de la certitude à tout ce que l'on a dit à cet égard. Il ne me reste plus qu'à désirer de pouvoir être, quelque jour, à portée de jouir de ce spectacle. Si notre intendant que nous attendons à la fin de ce mois a enfin trouvé des moyens pour exécuter notre grand projet de l'histoire naturelle du Dauphiné, il me sera peut-être donné d'ajouter quelques faits aux vôtres.
J'ai vu aussi dans le Journal de physique, le mémoire de M. Pujol. Il m'a paru bien fait, et propre à mettre les naturalistes en état de fixer enfin leurs idées sur ces pierres singulières qu'il a plu d'appeler priapolites. S'il vous en est parvenu, lors dela foire de Beaucaire, je tâcherai, en vous envoyant quelque chose, de vous fournir une occasion pour me les faire passer.

L'eau aérée mercurielle est une découverte constante, et un remède de plus contre les maux vénériens, il est même très actif en remède et il m'est arrivé depuis peu de voir que dix cuillerées à bouche ont excité la salivation. Prudemment ménagée, cette nouvelle ressource réussira toujours. J'attends encore quelques expériences pour l'annoncer sur les papiers publics, plus positivement que je ne l'ai fait jusques ici. Il a paru quelques foibles critiques, mais je n'ai d'autre réponse à faire [v] si ce n'est d'inviter les critiques à nous imiter, puisqu'ils croient la chose facile. Je pense que l'air fixe est une des clefs de la nature. Nous sommes enfans encore: le bel âge sera pour nos neveux.

Je vous envoie un peu de la mine d'Allemont en poudre; j'ai des morceaux intéressants de nickel que je tâcherai de vous faire parvenir.

Si M. Razoux auquel je vous prie d'offrir mes civilités, vouloit prendre la peine de faire des essais de l'eau aérée mercurielle, je vous en ferai passer quelques bouteilles. Ayez la bonté de me marquer si la chose est possible.

Nous possédons déjà deux vol. de la chymie de Dijon: cet ouvrage est lumineux et digne de ses auteurs.

Adieu, Monsieur et cher confrère: recevez l'accolade de l'estime et de la vénération avec laquelle je serai toute ma vie

Votre très humble et très obéissant serviteur

Nicolas
description: [personnes citées] Pujol, François Brette, Jean Razoux
description: [reférence bibliographique citée] Rozier François, Journal d'observations sur la physique, l'histoire naturelle et sur les arts et métiers, au Bureau du journal de physique, Paris, à part
description: Source: [lieu de Conservation] Grenoble, Bibliothèque municipale [cote]ms. 6210, lettre 14
Additional file 2: Figure S1. of Sequence analysis of European maize inbred line F2 provides new insights into molecular and chromosomal characteristics of presence/absence variants
Creators: name: Darracq, Aude
name: Vitte, Clémentine
name: Nicolas, Stéphane
name: Duarte, Jorge
name: Jean-Philippe Pichon
name: Mary-Huard, Tristan
name: Chevalier, Céline
name: Bérard, Aurélie
name: Marie-Christine Le Paslier
name: Rogowsky, Peter
name: Charcosset, Alain
name: Joets, Johann
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Quality analysis of F2 WGA in a gene-rich region. A. A MUMmer alignment showing that more than 44% of a 112.2 kb F2 BAC sequence from the Bronze locus is covered by 3 scaffolds from the F2 WGA. B. Nearly all genes of this region are assembled into one single scaffold while the two other scaffolds cover mostly non-genic DNA and TE. Gaps indicated by a star (A) or an orange box (B) delineate contigs of each scaffold. All contigs are correctly ordered and oriented even in non-genic regions. (PDF 464 kb)
Additional file 1 of AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells
Creators: name: Wang, Ganggang
name: Zhang, Hao
name: Zhou, Zhijie
name: Jin, Wenzhi
name: Zhang, Xin
name: Ma, Zenghui
name: Wang, Xiaoliang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1
LCMS-DNP based dereplication of Araucaria cunninghamii Mudie gum-resin: identification of new cytotoxic labdane diterpene
Creators: name: Sahu, Bharat
name: Bhardwaj, Nivedita
name: Chatterjee, Essha
name: Dey, Biswajit
name: Tripathi, Nancy
name: Goel, Bharat
name: Kushwaha, Manoj
name: Kumar, Brijesh
name: Singh, Bikarma
name: Guru, Santosh Kumar
name: Jain, Shreyans K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: As a part of natural defense, plants initiate the secretion of gum containing numerous pharmacologically active essential metabolites. A fraction of such gum-resin from Araucaria cunninghamii Mudie, when screened against human cancer cell lines, was found to be active. Further, it was subjected to an LCMS-DNP (Dictionary of Natural Products) based dereplication study followed by a detailed phytochemical investigation to obtain pure metabolites. Also, the gum resin of A. cunninghamii was found to be a rich source of abietanes and labdanes. The LCMS-DNP-based dereplication study identified many known metabolites, which were isolated for the first time from this plant as well as a new labdane diterpenoid (9). The compounds were characterized via spectroscopic techniques, which were subsequently compared with the already existing literature data. The metabolites were screened against seven human cancer cell lines. The anticancer activity was further supported by molecular docking studies.
Beyond Bilinear: Generalized Multimodal Factorized High-order Pooling for Visual Question Answering
Creators: name: Yu, Zhou
name: Yu, Jun
name: Xiang, Chenchao
name: Fan, Jianping
name: Tao, Dacheng
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Visual question answering (VQA) is challenging because it requires a simultaneous understanding of both visual content of images and textual content of questions. To support the VQA task, we need to find good solutions for the following three issues: 1) fine-grained feature representations for both the image and the question; 2) multi-modal feature fusion that is able to capture the complex interactions between multi-modal features; 3) automatic answer prediction that is able to consider the complex correlations between multiple diverse answers for the same question. For fine-grained image and question representations, a `co-attention' mechanism is developed by using a deep neural network architecture to jointly learn the attentions for both the image and the question, which can allow us to reduce the irrelevant features effectively and obtain more discriminative features for image and question representations. For multi-modal feature fusion, a generalized Multi-modal Factorized High-order pooling approach (MFH) is developed to achieve more effective fusion of multi-modal features by exploiting their correlations sufficiently, which can further result in superior VQA performance as compared with the state-of-the-art approaches. For answer prediction, the KL (Kullback-Leibler) divergence is used as the loss function to achieve precise characterization of the complex correlations between multiple diverse answers with the same or similar meaning, which can allow us to achieve faster convergence rate and obtain slightly better accuracy on answer prediction. A deep neural network architecture is designed to integrate all these aforementioned modules into a unified model for achieving superior VQA performance. With an ensemble of our MFH models, we achieve the state-of-the-art performance on the large-scale VQA datasets and win the runner-up in VQA Challenge 2017.
description: 13 pages, 9 figures. arXiv admin note: substantial text overlap with arXiv:1708.01471
title: Περιβαλλοντική Υπολογιστική Ρευστομηχανική
title: Προσομοίωση υδατικών συστημάτων με έμφαση στην προστασία περιβάλλοντος
titleType: AlternativeTitle
Creators: name: Sylaios, Georgios
name: Moutsopoulos, Konstantinos
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΠΡΟΣΟΜΟΙΩΣΕΙΣ ΡΟΩΝ
ΔΙΑΣΠΟΡΑ ΡΥΠΩΝ
ΕΦΑΡΜΟΣΜΕΝΗ ΡΕΥΣΤΟΜΗΧΑΝΙΚΗ
ΔΙΑΧΕΙΡΙΣΗ ΥΔΑΤΙΝΩΝ ΠΟΡΩΝ
Fluid Flow Models
Pollutants Dispersion
Applied Fluid Mechanics
Water Resources Management

description: Το βιβλίο αποτελείται από δύο μέρη. Το πρώτο μέρος ασχολείται με τη διδασκαλία των κύριων θεωρητικών εξισώσεων της περιβαλλοντικής ρευστομηχανικής. Σε αυτό αναλύονται διεξοδικά οι κύριες εξισώσεις μαθηματικών προσομοιώσεων των περιβαλλοντικών ροών (εξίσωση Navier-Stokes, συνέχειας, ολοκληρωμένη κατά το βάθος εξίσωση συνέχειας, ολοκληρωμένες πλευρικά εξισώσεις συνέχειας και κίνησης, εξίσωση μεταφοράς και διάχυσης ρύπου, εξισώσεων υπόγειων ροών), ενώ προσδιορίζονται oi εμπειρικές εξισώσεις εκτίμησης των συντελεστών τυρβώδους ιξώδους και τυρβώδους διάχυσης. Αναλύεται η μεθοδολογία επίλυσης των παραπάνω εξισώσεων με τη τεχνική των πεπερασμένων διαφορών και όγκων ελέγχου και παρουσιάζονται σειρά ασκήσεων και προβλημάτων.

Το δεύτερο μέρος παρουσιάζει εφαρμοσμένες περιβαλλοντικές ροές και τις διεργασίες μεταφοράς και διάχυσης ρύπων σε αυτές. Ειδικότερα αναλύονται οι διεργασίες και η προσομοίωση των φαινομένων μεταφοράς και διάχυσης ρύπου σε μονοδιάστατες ροές (π.χ., κανάλια, χείμαρροι, ποτάμια), διδιάστατες ροές (λίμνες, ταμιευτήρες, ποταμοεκβολές, παράκτια συστήματα) και σε τρισδιάστατες ροές (ανοικτή θάλασσα). Επιπλέον το μάθημα ασχολείται με τη μελέτη συμπεριφοράς υποθαλάσσιων φλεβών και πλουμίων που αναπτύσσονται στη παράκτια ζώνη, και ασχολείται με το βέλτιστο σχεδιασμό τέτοιων έργων ώστε να επιτυγχάνεται ο περιορισμός των περιβαλλοντικών επιπτώσεων. Τέλος, παρουσιάζονται παραδείγματα προσομοίωσης και διαχείρισης υπόγειου υδατικού δυναμικού.

Παρουσιάζεται η μεθοδολογία διακριτοποίησης του υπολογιστικού πεδίου, η διαδικασία απλοποίησης των τρισδιάστατων θεωρητικών εξισώσεων μέσω παραδοχών, η εφαρμογή αρχικών και οριακών συνθηκών και η δυνατότητα διασύνδεσης του ομοιώματος με άλλα ομοιώματα ευρύτερης ροής. Σε κάθε κεφάλαιο παρουσιάζονται εφαρμογές που έχουν αναπτύξει οι συγγραφείς και έχουν εφαρμόσει σε υπαρκτά υδατικά συστήματα.
LCMS-DNP based dereplication of Araucaria cunninghamii Mudie gum-resin: identification of new cytotoxic labdane diterpene
Creators: name: Sahu, Bharat
name: Bhardwaj, Nivedita
name: Chatterjee, Essha
name: Dey, Biswajit
name: Tripathi, Nancy
name: Goel, Bharat
name: Kushwaha, Manoj
name: Kumar, Brijesh
name: Singh, Bikarma
name: Guru, Santosh Kumar
name: Jain, Shreyans K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: As a part of natural defense, plants initiate the secretion of gum containing numerous pharmacologically active essential metabolites. A fraction of such gum-resin from Araucaria cunninghamii Mudie, when screened against human cancer cell lines, was found to be active. Further, it was subjected to an LCMS-DNP (Dictionary of Natural Products) based dereplication study followed by a detailed phytochemical investigation to obtain pure metabolites. Also, the gum resin of A. cunninghamii was found to be a rich source of abietanes and labdanes. The LCMS-DNP-based dereplication study identified many known metabolites, which were isolated for the first time from this plant as well as a new labdane diterpenoid (9). The compounds were characterized via spectroscopic techniques, which were subsequently compared with the already existing literature data. The metabolites were screened against seven human cancer cell lines. The anticancer activity was further supported by molecular docking studies.
How European Higher Education Institutions are funded? Modelling the interaction between activities, organizational characteristics and national specificities
Creators: name: Lepori, Benedetto
name: Mantegazzini, Barbara Antonioli
Publisher: name: Zenodo
Year: 2020
Subjects: Higher Education
Funding
Latent Class Model
Heterogeneity

description: The funding environment of European Higher Education Institutions (HEIs) has evolved towards a “new funding climate” characterized by austerity and competition for resources. The outcome is a differentiated setting in terms of streams, allocation methods and country-specific policies. The goal of this paper is to investigate empirically the extent of such differences and, specifically, how these are associated with organizational activities, with the different types of HEIs within the system and with the national funding environment. Our work shows how the combination of a large dataset comprising heterogeneous HEIs in different countries and of advanced statistical models (Latent Class Analysis and Multi-level analysis) allows extracting from the data information on characteristics that cannot be observed directly concerning HEI resourcing behaviour and the characteristics of national funding environment. The main outcome of this analysis is a parsimonious representation of the funding patterns of European HEIs: we identify distinct types of HEIs – for example research vs. educational-oriented HEIs – characterized by different levels and composition of resources and we show that such differences remain valid across European countries. At the same type, typological differences interact with country-specific patterns to yield variation between HEIs belonging to the same type. Our results have also some policy implications, suggesting that that funding reform are not isolated interventions and the knowledge of the structure of the national research system represents therefore an important information to design tailored funding systems.
Material Flow Analysis and Risk Assessment of Wastewater and Sludge Treatment in Bangkok, Thailand
Creators: name: Anazawa, Hideaki
Publisher: name: Environmental Engineering Association of Thailand
Year: 2021
Subjects: Material flow analysis
Human health risk assessment
Wastewater treatment plant
Removal efficiencies
Carcinogenic risk
Non-carcinogenic risk

description: Thai Environmental Engineering Journal (TEEJ), 35, 2, 13-28
Additional file 4: Table S2. of Embryonic stem cell-derived cardiomyocytes for the treatment of doxorubicin-induced cardiomyopathy
Creators: name: DanĂşbia Silva Dos Santos
name: Brasil, Guilherme
name: Isalira Ramos
name: Mesquita, Fernanda
name: Tais Kasai-Brunswick
name: Christie, Michelle
name: Cahli, Gustavo
name: Raiana Barbosa
name: Cunha, Sandro Da
name: Jonathas Pereira
name: Medei, Emiliano
name: Carvalho, Antonio Campos De
name: Carvalho, Adriana
name: Goldenberg, Regina
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: Computational Biology

description: Presenting a list of Gene Ontology Biological Processes of interest. (DOCX 12 kb)
Classification of lattice polytopes with small volumes
Creators: name: Hibi, Takayuki
name: Tsuchiya, Akiyoshi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 52B12, 52B20

description: In the frame of a classification of general square systems of polynomial equations solvable by radicals, Esterov and Gusev succeeded in classifying all spanning lattice polytopes whose normalized volumes are at most $4$. In the present paper, we complete to classify all lattice polytopes whose normalized volumes are at most $4$ based on the known classification of their $δ$-polynomials.
description: 12 pages, to appear in Journal of Combinatorics
Certain Simple Maximal Subfields in Division Rings
Creators: name: Aaghabali, Mehdi
name: Bien, Mai Hoang
Publisher: name: arXiv
Year: 2017
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 16K20, 16R50, 17A35

description: Let D be a division ring finite dimensional over its center F. The goal of this paper is to prove that for any positive integer n there exists a in D^(n); the n-th multiplicative derived subgroup, such that F(a) is a maximal subfield of D. We also show that a single depth-n iterated additive commutator would generate a maximal subfield of D.
description: We have made some editorial changes as well as changes in Lemma 9 and Theorem 10
Act now, save later: Scenarios of the economic consequences of (in)action on biodiversity in Scotland
Creators: name: Daniels-Creasey, Alys
name: Metzger, Marc
name: Clough, Julia
name: Wilson, Bruce
Publisher: name: University of Edinburgh
Year: 2024
Subjects: biodiversity
scenarios
Scotland
economy

description: This report explores two possible futures for Scotland following different pathways of (in)action on biodiversity, based on information discussed within a scenario workshop with stakeholders working in the fields of economics, biodiversity and wider environmental issues. While the report does not provide an economic analysis, the scenarios derived from the workshop and further evidence gathered through desk-based research build a picture of the economic consequences of biodiversity loss for Scotland. Part 1 outlines the two potential futures for Scotland which arose from the scenario workshop. Background information, including research methodology and information on drivers of biodiversity loss, impacts and costs of such losses, can be found in Part 2. For the full-length scenario narratives, please see Part 3. The report highlights that action to recover biodiversity has far-reaching benefits beyond the initial intervention, and that the positive effects of investing in nature now multiply the benefits over time.
A new liposomal nanocarrier for co-delivery of gedunin and p-glycoprotein siRNA to target breast cancer stem cells
Creators: name: Rana, Mohan Singh
name: Ediriweera, Meran Keshawa
name: Rajagopalan, Umapriyatharshini
name: Karunaratne, Desiree Nedra
name: Tennekoon, Kamani Hemamala
name: Samarakoon, Sameera Ranganath
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Gedunin is a secondary metabolite found in neem tree. Since the first discovery of this compound, its bio-active properties have been continuously evaluated. However, the low hydrophobicity of gedunin decreases its bioavailability and pharmacokinetic profile. In the present investigation, a new liposomal nanocarrier for co-delivery of gedunin and P-glycoprotein (P-gp) siRNA [siRNA coated liposomal gedunin (Lipo-Ged-siRNA)] was developed to improve the anti-proliferative activity of gedunin. Characteristics of prepared Lipo-Ged-siRNA demonstrated promising effects. Lipo-Ged-siRNA showed greater anti-proliferative effects (IC50-8.5 µg/mL) followed by pure gedunin (IC50- 40.2 µg/mL) in breast cancer stem cells (bCSCs). Immunofluorescence analysis demonstrated reduced expression of P-gp following exposure to Lipo-Ged-siRNA. Furthermore, Lipo-Ged-siRNA affected the expression of ABCB1, Cyclin D1, Bax, p53, and surviving genes in bCSCs.
Additional file 5: Figure S5. of Systematic comparison of small RNA library preparation protocols for next-generation sequencing
Creators: name: Cloelia Dard-Dascot
name: Naquin, Delphine
name: D’Aubenton-Carafa, Yves
name: Alix, Karine
name: Thermes, Claude
name: Dijk, Erwin Van
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Assessment of quantitative detection of synthetic RNAs with protocols TS1, TS5, Nf2, or S. Libraries were prepared from a synthetic RNA mixture in which RNA(OMe)1–6 were each at 1% final concentration, supplemented with random 21 nt RNAs (mix A). Alternatively, an RNA mixture was used in which the concentrations of RNA(OMe)1–6 were changed (mix B); see table 1 for details. The coefficients of determination (R2) were determined for the fold changes obtained with each protocol for the unmodified RNAs (R2OH, blue dots) and for the 2’OMe RNAs (R2OMe, red dots) separately, and for the collection of the unmodified and 2’ OMe RNA together (R2tot). The fold changes obtained with the various protocols were compared with the theoretical values and the different protocols were compared to each other. (PDF 1.01 mb)
Controllable electron spin dephasing due to phonon state distinguishability in a coupled quantum dot system
Creators: name: Gawełczyk, Michał
name: Krzykowski, Mateusz
name: Gawarecki, Krzysztof
name: Machnikowski, Paweł
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We predict a spin pure dephasing channel in electron relaxation between states with unequal Zeeman splittings, exemplified by a spin-preserving electron tunneling between quantum dots in a magnetic field. The dephasing is caused by a mismatch in electron $g$-factors in the dots leading to distinguishability of phonons emitted during tunneling with opposite spins. Combining multiband $\boldsymbol{k}{\cdot}\boldsymbol{p}$ modeling and dynamical simulations via a Master equation we show that this fundamental effect of spin measurement effected by the phonon bath may be widely controlled by the size and composition of the dots or on demand, via tuning of external fields. By comparing the numerically simulated degree of dephasing with the predictions of general theory based on distinguishability of environment states, we show that the proposed mechanism is the dominant phonon-related spin dephasing channel and may limit spin coherence time in tunnel-coupled structures at cryogenic temperatures.
description: 7 pages, 6 figures, 2 tables
Additional file 2 of AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells
Creators: name: Wang, Ganggang
name: Zhang, Hao
name: Zhou, Zhijie
name: Jin, Wenzhi
name: Zhang, Xin
name: Ma, Zenghui
name: Wang, Xiaoliang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 2
Semantic Foggy Scene Understanding with Synthetic Data
Creators: name: Sakaridis, Christos
name: Dai, Dengxin
name: Van Gool, Luc
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This work addresses the problem of semantic foggy scene understanding (SFSU). Although extensive research has been performed on image dehazing and on semantic scene understanding with clear-weather images, little attention has been paid to SFSU. Due to the difficulty of collecting and annotating foggy images, we choose to generate synthetic fog on real images that depict clear-weather outdoor scenes, and then leverage these partially synthetic data for SFSU by employing state-of-the-art convolutional neural networks (CNN). In particular, a complete pipeline to add synthetic fog to real, clear-weather images using incomplete depth information is developed. We apply our fog synthesis on the Cityscapes dataset and generate Foggy Cityscapes with 20550 images. SFSU is tackled in two ways: 1) with typical supervised learning, and 2) with a novel type of semi-supervised learning, which combines 1) with an unsupervised supervision transfer from clear-weather images to their synthetic foggy counterparts. In addition, we carefully study the usefulness of image dehazing for SFSU. For evaluation, we present Foggy Driving, a dataset with 101 real-world images depicting foggy driving scenes, which come with ground truth annotations for semantic segmentation and object detection. Extensive experiments show that 1) supervised learning with our synthetic data significantly improves the performance of state-of-the-art CNN for SFSU on Foggy Driving; 2) our semi-supervised learning strategy further improves performance; and 3) image dehazing marginally advances SFSU with our learning strategy. The datasets, models and code are made publicly available.
description: Accepted manuscript, 21 pages. The datasets, models and code have been made publicly available
Cytotoxic potential of Nephthea sp.-derived actinomycetes supported by metabolomics analysis
Creators: name: Abdelhafez, Omnia Hesham
name: Fahim, John Refaat
name: Rateb, Mostafa E.
name: Ngwa, Che J.
name: Pradel, Gabriele
name: Abdelmohsen, Usama Ramadan
name: Desoukey, Samar Yehia
name: Kamel, Mohamed Salah
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Soft corals and associated microorganisms are known to produce leads for anticancer drugs. Keeping this in mind, Nephthea sp.; a Red Sea soft coral was investigated for the first time using the OSMAC approach. Two isolates, Streptomyces sp. UR63 and Micrococcus sp. UR67 were identified. Their extracts revealed the presence of alkaloids, macrolides, quinones, fatty acids and terpenoids. Further comparison through a set of multivariate data analyses revealed their unique chemical profiles. The extracts displayed inhibitory potencies against HepG-2, Caco-2 and MCF-7 tumor cell lines with IC50 values ranging from 11.4 to 38.7 μg/mL when compared with the positive control, doxorubicin. The study not only highlights the cytotoxic potential of soft coral-associated actinomycetes but also shows the advantage of using the OSMAC approach in this regard.
Caregiver facial expressions towards infants from a child's perspective: impacts of gender, crying, ASD and language development
Creators: name: Nelson, Nicole
name: Rayner, Charlotte
name: Van Der Zant, Tamara
name: Tuza, Alexander Lajos
name: Holdsworth, Imogen Helena
name: Palmer, Kye
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Developmental Psychology
subject: Child Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: emotion
subject: emotion expression

description: Description:
Much of research on infants in psychology comes from testing in staged environments/laboratories on tasks that are novel or unfamiliar to the child. A new, naturalistic, and longitudinal video dataset, SAYcam (see Sullivan et al., 2021*), allows us to see whether some of these more theoretical understandings are borne out in the rich, everyday lives of three infants developing through toddlerhood.

We aim to explore the relationship between caregivers’ facial expressions towards infants and the:
- Gender of caregivers,
- Crying behaviour of infants,
- Future ASD diagnostic status of infants, and
- Language development of infants.

Data collection:
Some data have been collected but not yet analysed.

Study type:
Observational.

Method:
Facial expressions will be detected and analysed using iMotions integrated Affectiva AFFDEX software. This data will be manually reviewed for false positives and extended by coding for additional variables.

Variables of interest:
 1. Caregiver’s facial emotional expression:
 a) Category
 b) Complexity
 c) Expressivity (intensity)
 d) Infant-directedness
 e) Valence
 2. Caregiver:
 a) Frequency of face detection
 b) Gender
 c) Responsiveness to crying behaviour
 3. Infant:
 a) Age
 b) Crying behaviour
 c) Crying frequency
 d) Future ASD diagnostic status
 e) Language development (MCDI scores)

Analyses:
Mixed effects models will be used to analyse the dataset, allowing us to account for individual differences within children and randomness across multiple variables.

* Sullivan, J., Mei, M., Perfors, A., Wojcik, E., & Frank, M. C. (2021). SAYCam: A large, longitudinal audiovisual dataset recorded from the infant’s perspective. Open Mind, 5, 20–29. https://doi.org/10.1162/opmi_a_00039