cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of novel PfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking and in vivo antimalarial activity
Creators: name: V. K. Vyas
name: G. Qureshi
name: M. Ghate
name: H. Patel
name: S. Dalai
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) catalyses the fourth reaction of de novo pyrimidine biosynthesis in parasites, and represents an important target for the treatment of malaria. In this study, we describe pharmacophore-based virtual screening combined with docking study and biological evaluation as a rational strategy for identification of novel hits as antimalarial agents. Pharmacophore models were established from known PfDHODH inhibitors using the GALAHAD module with IC50 values ranging from 0.033 μM to 142 μM. The best pharmacophore model consisted of three hydrogen bond acceptor, one hydrogen bond donor and one hydrophobic features. The pharmacophore models were validated through receiver operating characteristic and Günere–Henry scoring methods. The best pharmacophore model as a 3D search query was searched against the IBS database. Several compounds with different structures (scaffolds) were retrieved as hit molecules. Among these compounds, those with a QFIT value of more than 81 were docked in the PfDHODH enzyme to further explore the binding modes of these compounds. In silico pharmacokinetic and toxicities were predicted for the best docked molecules. Finally, the identified hits were evaluated in vivo for their antimalarial activity in a parasite inhibition assay. The hits reported here showed good potential to become novel antimalarial agents.
Hyperxiphia semilutea Smith, new 2020
Creators: name: Smith, David R.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Hymenoptera (awaiting allocation)
Hyperxiphia
Hyperxiphia semilutea

description:  Hyperxiphia semilutea Smith, new species http://zoobank.org/EA3F7B97- 4A7A-4677-AC89-242A816BA731 ( Figs. 11–15) Diagnosis.—Mesonotum black with axillae and metanotum white; abdominal segment 1–6 mostly orange with white spots laterally on segments 1, 2, 5, 6. Sheath short, about 2X longer than broad. Description.—Female ( Fig. 11): Length 13.1 mm. Antenna black. Head black with orbits (except upper) and area below antennae yellow. Thorax black, yellow on: pronotum (black spot in middle), spot anterior to mesepisternum, spot posterior to each lateral lobe, metascutellum. Legs with coxae and trochanters yellow, femora black, fore and mid tibiae yellow, hind tibia yellow with apex black; tarsi with basitarsi yellow, rest black. Abdomen with tergite 1 and laterally on tergite 2 yellow, tergites 3–6 orange, 5 and 6 laterally yellow; 7th black, 8th yellow spot laterally, 9 apically yellow, 10 yellow. Wings hyaline, veins and stigma black. Head ( Figs. 14, 15): Frons with longitudinal carinae from level of hind ocelli through supraclypeal area. Antennae with ~18 antennomeres. Labial palpus with 4 palpomeres, maxillary palpus with 4 palpomeres; first palpomere about as long as remaining palpomeres combined; 3 rd palpomere very short; apical palpomere clublike. Eyes slightly diverging below, lower interocular distance about 1.2X eye height. Head from above short behind eyes, distance behind eyes slightly shorter than eye length. Thorax ( Figs. 12, 13): Propleuron shiny, few punctures mostly ventrally. Pronotum shiny, diagonal area of short carinae at center. Mesonotum, metanotum rugulose; shiny less punctate areas on outer lateral lobes and apex of mesoscutellum; downturned sides of mesoscutellum shiny. Mesopleuron shiny with punctures, punctures separated by interspaces equal to or more than puncture diameters; mesosternum shiny, without punctures; mesepimeron with fine cross carinae, metapleuron rugulose. Hind basitarsus slightly shorter than remaining tarsomeres combined. Abdomen: Sheath ( Fig. 11) short, about 2X longer than broad, subequal in length to basal plates. Male: Unknown. Type material.— Holotype female " Lao, Hua Phan Prov., Ban Saleui; Phou Pan Mt., 20 ° 13'30"N, 103 ° 59'26"E GPS, 1350 - 1900 m, 16- 18.05.2010, leg. C. Holzschuh + locals ( OML). Etymology.—Name is based on the partly orange abdomen. Remarks.—The yellow orbits, upper and lower margins of the pronotum, axillae, metanotum, and fifth, sixth, and apical segments of the abdomen will distinguish this species. The diverging eyes below and short sheath are also helpful.
description: Published as part of Smith, David R., 2020, New Species And New Records Of Xiphydriid Woodwasps (Hymenoptera: Xiphydriidae) From Southeastern Asia, pp. 135-146 in PROC. ENTOMOL. SOC. WASH 122 (1) on pages 139-141, DOI: 10.4289/0013-8797.122.1.135, http://zenodo.org/record/3728039
Teaching Scenario 3: The Charitable Trust
Creators: name: Suw Charman-Anderson
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: Students are encouraged to think about the ways in which STEM makes a positive difference to our lives, how there is a very broad spectrum of opportunities in STEM, and that STEM careers are not reserved just for the ‘super-geniuses’ or ‘brainiacs’.
Improved control of blood pressure and albuminuria among patients with type-2 diabetes in Finnish open care
Creators: name: Varis, Juha
name: Metsärinne, Kaj
name: Koivisto, Veikko
name: Niskanen, Leo
name: Rissanen, Aila
name: Virkamäki, Antti
name: Appelroth, Tina
name: Pöntynen, Nora
name: Poussa, Tuija
name: Kantola, Ilkka
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy

description: Risk of cardiovascular events within the diabetic population has decreased and survival increased with patients living longer and thus facing the development of end-stage renal disease (ESRD). This calls for good care of patient with diabetes with a focus on hypertension. Patient data were collected from 42 Finnish primary care centres. Each was asked to enrol 10–12 consecutive patients with type-2 diabetes between March 2011 and August 2012. Along with the office blood pressure measurements and laboratory tests, the presence of albuminuria was measured and glomerular filtration rate estimated (eGFR). The 2013 ESH criteria for diabetic hypertensive patients (<140/85 mmHg) was reached by 39% of all 625 study patients and 38% of the pharmacologically treated 520 patients. The absence of detectable albumin in urine was significantly associated with the control of systolic blood pressure and achievement of treatment goals. Beta blockers were the most common antihypertensive agents and patients treated with them had lower eGFR compared to those not treated with these agents. The blood pressure of patients was not in full concordance with the present guideline recommendations. However, satisfactory improvement in blood pressure control, reduction of albuminuria and hence ESRD prevention was achieved.
Falco urubitinga J. F. Gmelin 1788
Creators: name: Schmitt, Stéphane
name: Gouraud, Christophe
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Accipitriformes
Falconidae
Falco
Falco urubitinga

description: 16. Buffon’s “Urubitinga ” (full species)   16.1. Linnaeus (1758): not considered.
  16.2. Brisson (1759a: 445-446, 1763a: 128): “ AIGLE DU BRÉSIL ”, “ AQUILA BRASILIENSIS ” , species 12 of genus IX (“Aigle”, “ Aquila ”), order III, section 1.
OBSERVATION. — No direct observation. Description borrowed from Markgraf.
 REFERENCES. — Markgraf (1648: 214), “ Urubitinga ”; Jonston (1657: 146, pl. 61), based on Markgraf; Willughby (1676: 32), idem; Ray (1713: 8 no. 9), idem.
DISTRIBUTION. — Brazil.
 MODERN IDENTIFICATION. — The description of this bird, entirely based on Markgraf, clearly corresponds to * Buteogallus urubitinga urubitinga (J. F. Gmelin, 1788); see Herrmann (1989: 192).
 16.3. Linnaeus (1766): not considered.
  16.4. Buffon in Buffon & Guéneau de Montbeillard (1771a: 141), quarto edition; (1771b: 110), folio edition: “ URUBITINGA ” .
REMARK. — In spite of Buffon, the term “urubitinga ” never imposed itself in French, but it was admitted as a specific name in Latin from 1788 onwards.
OBSERVATION. — No direct observation. Description borrowed from Markgraf or Brisson.
 REFERENCES. — Markgraf (1648: 214); Brisson (1759a: 445).
DISTRIBUTION. — Brazil.
 MODERN IDENTIFICATION. — * Buteogallus urubitinga urubitinga (J. F. Gmelin, 1788); see the comments on Brisson.
  16.5. Gmelin (1788: 265): “ FALCO URUBITINGA ” G42 S70, order “ Accipitres ”. REFERENCES. — Brisson (1763a: 128); Willughby (1678: 64); Ray (1713: 8 no. 9); Buffon & Guéneau de Montbeillard (1771a: 141); Latham (1781: 41 no. 20), “Brasilian Eagle” based on Brisson, Buffon, Ray, Willughby.
DISTRIBUTION. — Brazil.
 MODERN IDENTIFICATION. — * Buteogallus urubitinga urubitinga (J. F. Gmelin, 1788); see Brisson.
 MODERN NOMENCLATURE. — Falco urubitinga J. F. Gmelin, 1788 is an available and valid name, the protonym of the name currently in use for the species.
description: Published as part of Schmitt, Stéphane & Gouraud, Christophe, 2024, The significance of Buffon and Guéneau de Montbeillard's Histoire naturelle des oiseaux ([1765] - 1783) in the taxonomy of birds: General presentation and correspondence between Buffon's " eagles " and the species acknowledged by Linnaeus (1758, 1766), Brisson (1759 - 1762), and Gmelin (1788 - 1789), pp. 361-409 in Zoosystema 46 (16) on pages 398-400, DOI: 10.5252/zoosystema2024v46a16, http://zenodo.org/record/12667134
Introduction to Teaching Scenarios
Creators: name: Suw Charman-Anderson
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: The use of scenarios in teaching is becoming more and more popular in schools at all levels. Scenario-based teaching not only allows children to explore a complex topic in depth, it also develops their skills in analytical thinking, collaboration, communication, and helps them develop confidence in those skills.
urThis document introduces teaching scenarios, and provides overviews of the three scenarios included in our education pack, plus links to relevant resources.
EP Storytelling for Sustainability
Creators: name: Amlani, Ahmed
name: Bertels, Stephanie
name: Hadler, Tara
Publisher: name: figshare
Year: 2016
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business
subject: 150303 Corporate Governance and Stakeholder Engagement
subject: 150305 Human Resources Management
subject: 150311 Organisational Behaviour

description: When people in organizations communicate, they often do it through stories. Our “Storytelling for Sustainability” guidebook was developed through the Embedding Project's Community of Practice process. It blends research with stories from practitioners in organizations working to embed sustainability to help you:
Understand what storytelling looks like in practice, and reflect on this in the context of your organization
Develop a sense of why stories are important for embedding sustainability
Learn from other practitioners’ experiences with storytelling and plan your own efforts
title: Domestic tourists 4WDing in Central Australia
title: implications for desert Aboriginal people
titleType: Subtitle
Creators: name: Jacobsen, Damien
Publisher: name: Charles Darwin University
Year: 2010

description: The question of what being a domestic tourist might actually mean has attracted limited inquiry despite the volume of research dedicated to tourists and tourist experiences in the literature. The present study engages with this dilemma because it sought to understand challenges domestic 4WD tourists travelling in desert Australia may herald for desert Aboriginal people involved in tourism. The study implements a research design combining Gadamer’s philosophical hermeneutics and visitor employed photography to consider how Being a domestic tourist may involve an ontological situation characterised by constitutive belonging. Using interpretive findings from a small sample of domestic tourists on a 4WD tag-along tour in Central Australia, this study acts as a step towards broader future inquiry. The findings suggest that the agency of the domestic tourists in this study reveals and upholds an idealised manner of historically constituted Being inherited from their dwelling within a broad community: Australia. As such, the domestic tourists in the study are proposed to uphold an inalienable relation with Central Australia. The study suggests that their Being is characterised by a situated freedom of perceiving Central Australian landscapes in accordance with their broad understanding and sense of belonging to Australia. The findings highlighted their avoidance of Aboriginal cultural landscape meaning that may have been intrinsic to their manner of Being. Further, the findings suggest that the domestic tourists in the study may have perceived 4WDing as symbiotic with idealised landscape conditions (the Outback), while also emulating a historically conditioned agency they perceived was available to them in Central Australia. The study findings raise various implications to inform future inquiry into the involvement of desert Aboriginal people in tourism, domestic tourism and desert 4WD tourism.
title: Programme SHCC, cycle 8, Politique(s) du cinéma, séances du 13 novembre 2014 au 15 juin 2015
Creators: name: Gauthier, Christophe
name: Kerlan, Anne
name: Vezyroglou, Dimitri
name: Séminaire Histoire Culturelle Du Cinéma
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Relation: http://purl.org/poi/crdo.vjf.cnrs.fr/cocoon-92425642-300c-49bd-8256-42300c59bd18
O-hydroxy Schiff Bases Derived from 2-Hydroxy-4-methoxy Benzaldehyde: Synthesis, X-Ray Studies and Hydrogen Bonding Attributes
Creators: name: A. L. Amrutha Kala
name: Nanishankar V. Harohally
name: S. Naveen
name: M. Ramegowda
name: N. K. Lokanath
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Plant Biology

description: The o-hydroxy Schiff bases consisting of N'-[(Z)-(2-hydroxy-4-methoxyphenyl)methylidene]pyridine-4-carbohydrazide and N'-[(Z)-(2-hydroxy-4-methoxyphenyl)methylidene]pyridine-3-carbohydrazide were prepared by reaction of isonicotinic acid hydrazide and nicotinic acid hydrazide by employing 2-hydroxy-4-methoxy benzaldehyde. The spectroscopic techniques, X-ray crystal structure determination as well as DFT calculations have been carried out to shed light on the nature of hydrogen bonding. The both experimental and theoretical investigations demonstrate the presence of intramolecular neutral hydrogen bonding (enol-imine type) in these molecules.
Falco aquilinus J. F. Gmelin 1788
Creators: name: Schmitt, Stéphane
name: Gouraud, Christophe
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Accipitriformes
Falconidae
Falco
Falco aquilinus

description: 17. Buffon’s “Petit Aigle d’Amérique” (full species)   17.1. Linnaeus (1758): not considered.
 17.2. Brisson (1759a): not considered.
 17.3. Linnaeus (1766): not considered.
  17.4. Buffon in Buffon & Guéneau de Montbeillard (1771a: 142), quarto edition; (1771b: 110-111, PE 417), folio edition: “ PETIT AIGLE D’ AMÉRIQUE ”.
 PE 417. — “Aigle d’Amerique” (published in March 1770). See Figure 4.
OBSERVATION. — Direct observation of an unknown specimen, seemingly mounted, probably sent from French Guiana. Buffon did not specify if the specimen belonged to the Royal Cabinet or to another collection. According to Mauduyt de La Varenne (1783: 474), this bird “has often been sent from [French] Guiana ”, which suggests that it was rather common in Parisian cabinets.
REFERENCES. — None (new species).
DISTRIBUTION. — Cayenne and “other parts of South America”.
 IDENTIFICATIONS PROPOSED BY LATER AUTHORS FOR PE 417. — Boddaert (1783: 25): Latham (1781: 97 no. 82, “Red-throated Falcon”; refers to Buffon); Boddaert assigns this bird to the Linnaean genus “ Falco ” (G42) and names it “ Falco americanus ” (available and valid name: see below).
 Kuhl (1820: 7): “ Falco Aquilinus L. ”
 Temminck (1839: 2): “Caracara à gorge nue ou Rancanca”; “ Falco aquilinus. Linn.”
 Gray (1849: 33): “ Ibycter americanus ”.
 MODERN IDENTIFICATION. — * Ibycter americanus (Boddaert, 1783), according to the plate and the description; the (lost) illustrated specimen is the holotype.
 MODERN NOMENCLATURE. — Falco americanus Boddaert, 1783 is an available and valid name, the protonym of the name currently in use for the species.
  17.5. Gmelin (1788: 280): “  FALCO AQUILINUS  ” G42, S110, order “ Accipitres ”. REFERENCES. — Buffon & Guéneau de Montbeillard (1771a: 142) and PE 417; Latham (1781: 97 no. 82, based on Buffon).
DISTRIBUTION. — South America.
 MODERN IDENTIFICATION. — * Ibycter americanus (Boddaert, 1783).
 MODERN NOMENCLATURE. — Falco aquilinus J. F. Gmelin, 1788 is an available name,
 a junior synonym of Falco americanus Boddaert, 1783.
description: Published as part of Schmitt, Stéphane & Gouraud, Christophe, 2024, The significance of Buffon and Guéneau de Montbeillard's Histoire naturelle des oiseaux ([1765] - 1783) in the taxonomy of birds: General presentation and correspondence between Buffon's " eagles " and the species acknowledged by Linnaeus (1758, 1766), Brisson (1759 - 1762), and Gmelin (1788 - 1789), pp. 361-409 in Zoosystema 46 (16) on page 400, DOI: 10.5252/zoosystema2024v46a16, http://zenodo.org/record/12667134
Synthesis and Crystal Structure of bis [2-(3-(2-((2-Hydroxybenzylidene) Amino)Ethyl)Oxazolidin-2-yl)Phenol]Cerium (IV) 1,4-Dioxane Monosolvate
Creators: name: G.Y.S.K. Swamy
name: P. Sivanarayanan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology
subject: 60506 Virology

description: The metal complex, bis [2-(3-(2-((2-hydroxybenzylidene)amino)ethyl) oxazolidin-2-yl)phenol]cerium(IV) 1,4-dioxane monosolvate was synthesized and characterized by infrared, 1H NMR, elemental analysis, single-crystal, and powder X-ray diffraction. The coordination polyhedra of cerium shows a distorted square-antiprismatic geometry. No classical hydrogen bonds were observed. The crystal packing was influenced by weak C-H···O (intermolecular) and van der Waals interactions.
Cost effectiveness of meniscal allograft for torn discoid lateral meniscus in young women
Creators: name: Ramme, Austin J.
name: Strauss, Eric J.
name: Jazrawi, Laith
name: Gold, Heather T.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Objective: A discoid meniscus is more prone to tears than a normal meniscus. Patients with a torn discoid lateral meniscus are at increased risk for early onset osteoarthritis requiring total knee arthroplasty (TKA). Optimal management for this condition is controversial given the up-front cost difference between the two treatment options: the more expensive meniscal allograft transplantation compared with standard partial meniscectomy. We hypothesize that meniscal allograft transplantation following excision of a torn discoid lateral meniscus is more cost-effective compared with partial meniscectomy alone because allografts will extend the time to TKA. Methods: A decision analytic Markov model was created to compare the cost effectiveness of two treatments for symptomatic, torn discoid lateral meniscus: meniscal allograft and partial meniscectomy. Probability estimates and event rates were derived from the scientific literature, and costs and benefits were discounted by 3%. One-way sensitivity analyses were performed to test model robustness. Results: Over 25 years, the partial meniscectomy strategy cost $10,430, whereas meniscal allograft cost on average $4040 more, at $14,470. Partial meniscectomy postponed TKA an average of 12.5 years, compared with 17.30 years for meniscal allograft, an increase of 4.8 years. Allograft cost $842 per-year-gained in time to TKA. Conclusion: Meniscal allografts have been shown to reduce pain and improve function in patients with discoid lateral meniscus tears. Though more costly, meniscal allografts may be more effective than partial meniscectomy in delaying TKA in this model. Additional future long term clinical studies will provide more insight into optimal surgical options.
Biodiversity and trophic structure of invertebrate assemblages associated with understorey red algae in a Laminaria digitata bed
Creators: name: Schaal, Gauthier
name: Jean-Charles Leclerc
name: Droual, Gabin
name: Leroux, Cedric
name: Riera, Pascal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Although the composition of invertebrate assemblages associated with kelps has motivated several studies in the recent past, little is known about assemblages associated with smaller, understorey macroalgae in these ecosystems. Here, the composition of invertebrate assemblages living within understorey macroalgae of a kelp (Laminaria digitata) forest has been studied over two sampling dates, and the structure of the food web investigated using stable isotopes. A total of 145 species of mobile fauna, mainly amphipods and gastropods, were identified. Although differences were date-dependent, we showed that the three species considered (Palmaria palmata, Mastocarpus stellatus, Ellisolandia elongata) sheltered different associated assemblages, including high host-specificity, which suggests that the animal diversity associated with rocky shores is enhanced by a high algal diversity. Overall, a dominance of gastropods was observed for the two-dimensional, leaf-like P. palmata, while the three-dimensionally structured species (M. stellatus, E. elongata) were characterized by a dominance of amphipods. Stable isotopes highlighted different trophic structures; E. elongata-associated assemblages were most likely relying on a dominant food source, sediment organic matter, while other assemblages were based on a wider diversity of food sources (algae, sediment, suspended organic matter). Our results illustrate the need to consider the microhabitats formed by understorey macroalgae in order to thoroughly assess the diversity and understand the functioning of coastal rocky ecosystems.
Leptophytum flavescens comb. nov. (Corallinales, Rhodophyta), an Arctic endemic from the sublittoral of NW Spitsbergen, North Norway, and western Novaya Zemlya, with epitypification of L. laeve
Creators: name: Athanasiadis, Athanasios
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Type material of Lithothamnion flavescens Kjellman, originally described from Karlsøy (Troms) and Karmakul Bay (Novaya Zemlya), is re-examined and a lectotype is selected. Type specimens and other collections from NW Spitsbergen and North Norway possess distinctive characters of the genus Leptophytum, including the development of flattened epithallial cells, short subepithallial cells, and simple spermatangial structures. Leptophytum flavescens (Kjellman) comb. nov. resembles the generitype Leptophytum laeve, differing in having: (1) a thicker perithallium, to 900 µm (vs. 350 µm in L. laeve), that embeds older conceptacles, and (2) non-differentiated (in size or shape) pore cells of multiporate roofs. An epitype for L. laeve is also selected, which consolidates the status of this species and the genus, in agreement with the current literature and all publications prior to 1996.
Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil
Creators: name: Rosângela Maria Gomes
name: Júnior, Augusto Afonso Guerra
name: Lemos, Lívia Lovato Pires De
name: Costa, Juliana De Oliveira
name: Almeida, Alessandra Maciel
name: Alvares, Juliana
name: Filho, Charles Simão
name: Mariângela Leal Cherchiglia
name: Andrade, Eli Iola Gurgel
name: Godman, Brian
name: Acurcio, Francisco Assis
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little is known about long term survival rates. The project aim was to compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health System (SUS) prescribed either immunosuppressant. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.
Superacid-catalyzed tandem Meyer–Schuster rearrangement/intramolecular hydroamination of o-anilinopropargyl alcohols for the synthesis of 2,3-dihydro-4(1H)-quinolones
Creators: name: Guofeng Sun
name: Fengkai Cheng
name: Ruiheng Tao
name: Yuxing Sun
name: Jinpeng Pan
name: Yaohua Zhu
name: Zhonghua Wang
name: Fanhong Wu
name: Yin, Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A TfOH-catalyzed synthesis of 2,3-dihydro-4(1H)-quinolones from o-anilinopropargyl alcohols was developed. Studies of N-protecting groups and substituents in phenyl rings showed that diverse groups could be applied. By controlling the catalyst loading, o-anilinopropargyl alcohols underwent the expected transformation smoothly to produce N-protected or N-deprotected 2,3-dihydro-4 (1H)-quinolones in good yields. This transformation probably involved a tandem Meyer–Schuster rearrangement/intramolecular hydroamination reaction process.
Superacid-Catalyzed Tandem Meyer-Schuster Rearrangement/Intramolecular Hydroamination of o-Anilinopropargyl Alcohols for the Synthesis of 2,3-dihydro-4(1 h)-quinolones
Creators: name: Guofeng Sun
name: Fengkai Cheng
name: Ruiheng Tao
name: Yuxing Sun
name: Jinpeng Pan
name: Yaohua Zhu
name: Zhonghua Wang
name: Fanhong Wu
name: Yin, Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A TfOH-catalyzed synthesis of 2,3-dihydro-4(1H)-quinolones from o-anilinopropargyl alcohols was developed. Studies of N-protecting groups and substituents in phenyl ring showed that diverse groups could be applied. Controlling the catalyst loading, o-anilinopropargyl alcohols underwent the expected transformation smoothly to produce N-protected orN-deprotected 2,3-dihydro-4 (1H)-quinolones in good yields. This transformation probably involved a tandem Meyer-Schuster rearrangement/intramolecular hydroamination reaction process.
Defining Cancer Subtypes With Distinctive Etiologic Profiles: An Application to the Epidemiology of Melanoma
Creators: name: Mauguen, Audrey
name: Zabor, Emily C.
name: Thomas, Nancy E.
name: Berwick, Marianne
name: Venkatraman E. Seshan
name: Begg, Colin B.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: We showcase a novel analytic strategy to identify subtypes of cancer that possess distinctive causal factors, that is, subtypes that are “etiologically” distinct. The method involves the integrated analysis of two types of study design: an incident series of cases with double primary cancers with detailed information on tumor characteristics that can be used to define the subtypes; a case-series of incident cases with information on known risk factors that can be used to investigate the specific risk factors that distinguish the subtypes. The methods are applied to a rich melanoma dataset with detailed information on pathologic tumor factors, and comprehensive information on known genetic and environmental risk factors for melanoma. Identification of the optimal subtyping solution is accomplished using a novel clustering analysis that seeks to maximize a measure that characterizes the distinctiveness of the distributions of risk factors across the subtypes and that is a function of the correlations of tumor factors in the case-specific tumor pairs. This analysis is challenged by the presence of extensive missing data. If successful, studies of this nature offer the opportunity for efficient study design to identify unknown risk factors whose effects are concentrated in defined subtypes. Supplementary materials for this article are available online.
Defining Cancer Sub-Types with Distinctive Etiologic Profiles: An Application to the Epidemiology of Melanoma
Creators: name: Mauguen, Audrey
name: Zabor, Emily C.
name: Thomas, Nancy E.
name: Berwick, Marianne
name: Venkatraman E. Seshan
name: Begg, Colin B.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: We showcase a novel analytic strategy to identify sub-types of cancer that possess distinctive causal factors, i.e. sub-types that are “etiologically” distinct. The method involves the integrated analysis of two types of study design: an incident series of cases with double primary cancers with detailed information on tumor characteristics that can be used to define the sub-types; a case-series of incident cases with information on known risk factors that can be used to investigate the specific risk factors that distinguish the sub-types. The methods are applied to a rich melanoma dataset with detailed information on pathologic tumor factors, and comprehensive information on known genetic and environmental risk factors for melanoma. Identification of the optimal sub-typing solution is accomplished using a novel clustering analysis that seeks to maximize a measure that characterizes the distinctiveness of the distributions of risk factors across the sub-types and that is a function of the correlations of tumor factors in the case-specific tumor pairs. This analysis is challenged by the presence of extensive missing data. If successful, studies of this nature offer the opportunity for efficient study design to identify unknown risk factors whose effects are concentrated in defined sub-types.
Indium(III) chloride–catalyzed facile synthesis of oxabicyclo[3.3.1]nonenes via (3,5)-oxonium-ene cyclization
Creators: name: Kulathooran Singaram
name: Dhamodaran Marimuthu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: A practical and convenient method for the synthesis of oxabicyclo[3.3.1]nonenes has been developed using InCl3 (20 mol%) under mild conditions from aldehydes and R-(+)-limonene. Corresponding oxabicyclic compounds were obtained in high yields via (3,5)-oxonium-ene reaction. This protocol tolerates a wide range of substituents and functional groups. Mild reaction conditions, shorter time, and convenient workup makes this methodology practical.
Indium(III)chloride Catalysed Facile Synthesis of Oxabicyclo[3.3.1]nonenes via (3,5)-oxonium-Ene Cyclization
Creators: name: Kulathooran Singaram
name: Dhamodaran Marimuthu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: A practically convenient method for the synthesis of oxabicyclo[3.3.1]nonenes have been developed using InCl3(20 mol%) under mild conditions from aldehydes and R-(+)-limonene. Corresponding oxabicyclic compounds were obtained in high yields via (3,5)-oxonium-ene reaction. This protocol tolerates wide range of substituents and functional groups. Mild reaction conditions, shorter time and convenient workup makes this methodology more practical.
Robust design space development for HPLC analysis of five chemical components in Panax notoginseng saponins
Creators: name: Shengyun Dai
name: Xu, Bing
name: Zhang, Yi
name: Sun, Fei
name: Jianyu Li
name: Xinyuan Shi
name: Yanjiang Qiao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: The present work describes the systematic development of a robust, precise, and rapid reversed-phase liquid chromatography method for the simultaneous analysis of five chemical components in Panax notoginseng saponins (PNS) using quality by design (QbD). The method was developed in two main phases: screening and optimization. During the screening phase, the most suitable stationary phase, column temperature, and flow rate were identified, while the secondary influential parameters, such as the gradient slope, the initial concentration of acetonitrile, and the initial isocratic hold of the gradient elution system were fine-tuned in the later optimization phase. In this phase, a 17-run experiment was used to examine multifactorial effects of these parameters on the critical resolution, analysis time, and peak symmetry. The Monte Carlo simulation method was successfully used to build the chromatographic design space and the process capability index Cp was introduced to evaluate the robustness of the design space. At last, the verification experiment was performed within the working design space by the accuracy profile methodology and model was found to be accurate. A robust combination of separation conditions predicted in the design space was obtained with the gradient slope of 1.6% · min−1, the initial concentration of acetonitrile of 20%, and the initial isocratic hold of 20 min, and the total analysis time was no more than 40 min. The results demonstrated that rapid separation of five components of PNS herbal extract could be achieved on the chromatographic column packed with narrow size particles at backpressures available in ordinary high performance liquid chromatography (HPLC) instruments.
Preparations of N- and P-substituted acetylenes under metal-free conditions
Creators: name: Chen, Hong
name: Qingjuan Zheng
name: Wanrong Dong
name: Zhihong Peng
name: Delie An
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: An efficient strategy towards triazole- or phosphine-oxide-substituted alkynes with the assistance of strong base LiHMDS is described. The facile and practical reaction took place from easily prepared substrates in a one-pot manner without participation of any transition metal catalysts or ligands, exhibiting good functional groups tolerance (up to 37 examples) and high efficiency (up to 90% yields). The isolation of the key intermediate proved the hypothesis of the proposed mechanism of the one-pot preparation.
Preparations of N and P Substituted Acetylenes Under Metal-free Conditions
Creators: name: Chen, Hong
name: Qingjuan Zheng
name: Wanrong Dong
name: Zhihong Peng
name: Delie An
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: An efficient strategy towards triazole or phosphine oxide substituted alkynes with assistance of strong base LiHMDS was herein described. The facile and practical reaction took place from easily-prepared substrates in a one-pot manner without participation of any transition metal-catalysts or ligands, exhibiting good functional groups tolerance (up to 37 examples) and high efficiency (up to 90% yields). The isolation of the key intermediate proved the hypothesis of the proposed mechanism of the one-pot preparation.
Identification, characterization, and synthesis of process-related impurities in antiproliferative agent TQ-B3203
Creators: name: Xiquan Zhang
name: Cao, Meng
name: Xing, Jing
name: Zheng, Ming
name: Liu, Fei
name: Dong, Ping
name: Tian, Xin
name: Hongjiang Xu
name: Laifang Zhang
name: Hongmei Gu
name: Yang, Ling
name: Li, Rui
name: Ji, Min
name: Gu, Ning
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Liposoluble camptothecin derivative, research name TQ-B3203, is a recently developed investigational antiproliferative agent by our group. The structure of TQ-B3203 is 2-(hexadecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate, containing an SN-38 component, a trolox component, a succinic acid linker, and a hexadecanol chain. In this study, the process-related impurities of bulk TQ-B3203 were identified, characterized, and synthesized. Seven major impurities were revealed based on the mass spectrum (MS) and nuclear magnetic resonance (NMR) spectral data. They were characterized as SN-38 (IMP-I), trolox (IMP-II), 2-(dodecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate (IMP-III), hexadecyl 7-ethyl-camptothecin-10-yl succinate (IMP-IV), 2-(tetradecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate (IMP-V), 4-(2-(hexadecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yloxy)-4-oxobutanoic acid (IMP-VI), and 4-(2-(octodecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yloxy)-4-oxobutanoic acid (IMP-VII). The probable origin of the impurities from the preparation process of TQ-B3203 was discussed.
Identification, Characterization and Synthesis of Process Related Impurities in Antiproliferative Agent TQ-B3203
Creators: name: Xiquan Zhang
name: Cao, Meng
name: Xing, Jing
name: Zheng, Ming
name: Liu, Fei
name: Dong, Ping
name: Tian, Xin
name: Hongjiang Xu
name: Laifang Zhang
name: Hongmei Gu
name: Yang, Ling
name: Li, Rui
name: Ji, Min
name: Gu, Ning
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Liposoluble camptothecin derivative, research name TQ-B3203, is a recently developed investigational antiproliferative agent by our group. The structure of TQ-B3203 is 2-(hexadecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate, containing a SN-38 component, a trolox component, a succinic acid linker and a hexadecanol chain. In this study, the process related impurities of bulk TQ-B3203 were identified, characterized and synthesized. Seven major impurities were revealed based on the MS and NMR spectral data. They were characterized as SN-38 (IMP-I), trolox (IMP-II), 2-(dodecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate (IMP-III), hexadecyl 7-ethyl-camptothecin-10-yl succinate (IMP-IV), 2-(tetradecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yl 7-ethyl-camptothecin-10-yl succinate (IMP-V), 4-(2-(hexadecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yloxy)-4-oxobutanoic acid (IMP-VI) and 4-(2-(octodecyloxycarbonyl)-2,5,7,8-tetramethylchroman-6-yloxy)-4-oxobutanoic acid (IMP-VII). The probable origin of the impurities from the preparation process of TQ-B3203 was discussed.
Falco antillarum J. F. Gmelin 1788
Creators: name: Schmitt, Stéphane
name: Gouraud, Christophe
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Accipitriformes
Falconidae
Falco
Falco antillarum

description: 19. Buffon’s “Mansfeni” (full species)   19.1. Linnaeus (1758): not considered.
  19.2. Brisson (1759a: 361, 1763a: 104-105): “ FAUCON DES ANTILLES ”, “ FALCO ANTILLARUM ” , species 13 of genus VIII (“Épervier”, “ Accipiter ”), order III, section 1.
OBSERVATION. — No direct observation. Description borrowed from Du Tertre.
REFERENCES. — Du Tertre (1667: 252), “Mansfeny”; possible direct observation; Ray (1713: 19 no. 1), based on Du Tertre.
DISTRIBUTION. — Antilles.
MODERN IDENTIFICATION. — The species cannot be identified. Ray and Brisson rely on Du Tertre’s very imprecise description (a bird of prey resembling an eagle, same size as a falcon but with bigger claws; eats birds and snakes); furthermore, the word “mansfeni” (whose origin is unclear) seems to have designated several birds in the Antilles, including the frigatebird.
 19.3. Linnaeus (1766): not considered.
  19.4. Buffon in Buffon & Guéneau de Montbeillard (1771a: 144- 145), quarto edition; (1771b: 112-113), folio edition: “ MANSFENI ” .
OBSERVATION. — No direct observation. Description borrowed from Du Tertre.
REFERENCE. — Du Tertre (1667: 252).
DISTRIBUTION. — Antilles.
MODERN IDENTIFICATION. — Unidentified bird of prey: see the comments on Brisson.
  19.5. Gmelin (1788: 264): “ FALCO ANTILLARUM ” G42, S65, order “ Accipitres ”. REFERENCES. — Brisson (1763a: 104); Ray (1713: 19 no. 1); “Du Tartre” = Du Tertre (1667: 252); Buffon & Guéneau de Montbeillard (1771a: 144); Latham (1781: 47 no. 27), “Mansfeny”, based on Brisson, Buffon, Du Tertre, Ray.
DISTRIBUTION. — Antilles.
 MODERN IDENTIFICATION. — Unidentified bird of prey: see the comments on Brisson. Gmelin says that the top of the head is black and the abdomen white, which obviously results from a confusion between Brisson’s “ Falco Antillarum ” and “ Falco piscator Antillarum ”; however, Gmelin mentions the latter in the list of references for “ Falco carolinensis ”: see above.
 MODERN NOMENCLATURE. — Falco antillarum J. F. Gmelin, 1788, is a nomen dubium.
description: Published as part of Schmitt, Stéphane & Gouraud, Christophe, 2024, The significance of Buffon and Guéneau de Montbeillard's Histoire naturelle des oiseaux ([1765] - 1783) in the taxonomy of birds: General presentation and correspondence between Buffon's " eagles " and the species acknowledged by Linnaeus (1758, 1766), Brisson (1759 - 1762), and Gmelin (1788 - 1789), pp. 361-409 in Zoosystema 46 (16) on page 401, DOI: 10.5252/zoosystema2024v46a16, http://zenodo.org/record/12667134