cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Frequency and clinical relevance of potential cytochrome P450 drug interactions in a psychiatric patient population – an analysis based on German insurance claims data
Creators: name: Ostermann, Julia K.
name: Berghoefer, Anne
name: Andersohn, Frank
name: Fischer, Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Secondary data analysis
subject: Health claims data
subject: CYP450
subject: Drug-drug exposure
subject: Drug-drug interaction
subject: Antidepressants
subject: Antipsychotics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Numerous drugs used in the treatment of psychiatric disorders are substrates of cytochrome P450 enzymes and are potential candidates for drug- drug interactions (DDIs). Methods Claims data of a German statutory health insurance company from severely mentally ill patients who registered in an integrated care contract from August 2004 to December 2009 were analysed. We measured time periods of concomitant prescription of drugs that have been reported to interact via cytochrome P450, with a focus on drugs acting as strong inhibitors. Such drug-drug exposure (DDE) is an incontrovertible precursor of DDIs. We assessed whether potential DDIs were considered clinically relevant based on the prescribing information of the respective drugs. Results Among all 1221 patients, 186 patients (15.2 %; Clopper-Pearson 95 % confidence interval (CI): 13.3–17.4 %) had at least one DDE prescription, and 58 patients (4.8 %; 95 % CI 3.6–6.1) had at least one DDE prescription involving a strong cytochrome P450 inhibitor. In 59 patients, (4.8 %; 95 % CI: 3.7–6.2 %) five or more DDEs were identified, and five or more DDEs with a strong inhibitor were identified in 18 patients (1.5 %; 95 % CI: 0.9–2.3). The rates of DDEs were 0.27 (Garwood 95%CI: 0.25–0.28) per person-year and 0.07 (95 % CI: 0.07–0.08) for strong-inhibitor DDEs. Four of the ten most frequent DDEs were identified as clinically relevant, and seven of the eight most frequent DDEs involving a strong inhibitor were clinically relevant. Conclusions The number of patients with DDEs was not alarmingly high in our sample. Nevertheless, prescription information showed that some prescribed drug combinations could result in serious adverse consequences that are known to weaken or strengthen the effect of the drugs and should therefore be avoided.
Attitudes and decision making in digital education
Creators: name: Dawson, David Geoffrey
Publisher: name: Swinburne
Year: 2024

description: Schools face monumental challenges when implementing digital technologies and training stakeholders in using digital technologies and in acquiring digital literacy. In this mixed-methods research, surveys were conducted, and data analysis indicated significant differences in attitudes and disconnects between educators and students. These disconnects were related to training and decision-making that impacted on effective use of digital technologies. In-depth follow-up interviews were conducted with educators skilled in digital technologies. Decision-making was confirmed as a factor limiting uses of digital technologies, undermining implementations, curriculum applications and effective training. Poor school management practices were uncovered, and recommendations made for managing digital technology systems.
Resiliência e ir além de si mesmo: analise do artigo "resiliência e psicologia transpessoal"
Creators: name: Oliveira, Lúcia Martins Pereira de
Publisher: name: Zenodo
Year: 2024
Subjects: resili
transpessoal
superação
fatores de risco
fatores de proteção
interpessoais
transcedência

description: A principal característica de um comportamento resiliente é ter a “habilidade para lidar e se adaptar aos momentos difíceis da vida”, pois quando tudo está bem é fácil ver a existência como algo colorido, ter expectativas para o futuro, fazer planos, por exemplo. Mas são nas situações complicadas, como tragédias pessoais, desastres de qualquer natureza ou mesmo o estresse diário acentuado, que a pessoa precisa ser resiliente. Pois, essa é prática que faz com “que a maioria das pessoas sejam maleáveis – do ponto de vista psicológico – e reajam quando chegam ao “fundo do poço”, visto que é nessa fase que muito não conseguem se reerguer, visto que ser resiliente é vivenciar o processo que leva à superação de problemas, crises ou infortúnio, seja como indivíduos, grupos e organizações.
title: Contextualizing Health Disparities
title: The Role of Social Support, Internalized Stigma, and State Policy Climate in Shaping Substance Abuse and Mental Distress Among Sexual Minority Adults
titleType: Subtitle
Creators: name: Cooley, Caleb Cameron
Publisher: name: Washington State University
Year: 2025
Subjects: Sexual Minority
Social Factors
Social Support
State Policy
Sexuality
Mental Health
Substance Abuse

description: This three-article style dissertation examines disparities in substance abuse and mental health among sexual minorities, focusing on the roles of social support, internalized homophobia, and state policies. Utilizing data from the Generations Study, it highlights the nuanced and varied experiences of lesbian, gay, bisexual individuals, as well as those of other sexual orientations. Study One identifies the differential impact of social support on mental health and substance abuse, revealing that while social support generally attenuates negative mental health outcomes for gay and lesbian individuals, bisexuals still experience higher rates of substance abuse and mental distress regardless of support levels. Study Two investigates how internalized homophobia impacts rates of substance abuse and mental distress. Results indicate that bisexuals, and to a lesser extent other sexual minorities, consistently report higher substance abuse and mental health scores compared to lesbians and gays. This suggests that bisexual individuals may face higher levels of stress and greater stigmatization due to their sexual orientation. Study Three explores the role of state-level policies, demonstrating that protective policies do not uniformly translate into better health outcomes. Interestingly, lesbian and gay individuals in protectivestates report higher substance abuse rates than those in discriminatory states, suggesting that the policy context within states can vary significantly by city or municipality. In contrast, bisexuals show elevated mental distress across all policy climates, implying that structural protections may be insufficient to address their specific stressors. The dissertation reveals that while social support and progressive policies provide some resiliency, they do not fully protect against the higher propensity for substance abuse and mental distress among bisexuals and other sexual minorities. These findings underscore the need for data collection that reflects the diverse contexts and experiences within the LGBTQ+ community, to better understand the social factors which contribute to the health disparities experienced among sexual minorities.
Gifted women's perspectives on giftedness and success.
Creators: name: Norgang, Gloria.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Women's Studies.

description: The prototypical study of giftedness is the study of youth selected on the basis of the IQ score. Its counterpart, in the study of success, is the study of eminent men, particularly those who have achieved in the domains of science or mathematics. Though research concerning giftedness and success has been more varied than these models, they are reflective of research tendencies toward: the equation of giftedness with IQ; the focus on youth as a potential national resource; the measurement of success in product-oriented competitive terms such as vocational achievement or eminence; and the relative neglect of adult women in the study of success. To address areas disregarded in the above-mentioned research predilections, the present study was intended to explore more inclusive approaches to giftedness and success. More specifically, it was designed to address the following two concerns: (1) the need for research regarding gifted women selected and studied on the basis of definitions of giftedness which include developmental, creative, and emotional aspects of giftedness; and (2) the need for research concerning gifted women's perspectives on giftedness and success. The study was informed by a feminist perspective, and included a criterion-based selection of 13 Canadian adult women, ages 19-56, who were identified on the basis of their participation in ultrarunning events of 50-1300 miles in length. Two non-hierarchical interviews, of approximately two hours, were conducted with each woman. The data were analyzed qualitatively, and this iterative process was supported by the use of a reflexive journal, and by peer debriefing. A preliminary report of all findings was submitted to the participants in the study for member checking. The results of the present study indicate that gifted women's perspectives are consistent in some ways with the definitions of giftedness and success common in the research literature. Where they denote a difference is in these women's relative disinterest in product-oriented approaches and their emphasis on process-oriented approaches. Their definitions of giftedness focused on: the discovery and application of one's gifts, belief in self, compassion, and transformation. With regard to success, they emphasized: living consciously, inner recognition, and community. (Abstract shortened by UMI.)
On the Sp_2n-distinguished Automorphic Spectrum of U_2n
Creators: name: Xin, Yu
Publisher: name: Brandeis University
Year: 2023

description: In this thesis, we studied the $H$-distinction for the pair $(G,H) = (U_{2n},Sp_{2n})$. We first derived a formula for period integrals of pseudo-Eisenstein series of $U_{2n}$. With the formula, we gave an upper bound of the $H$-distinguished spectrum in terms of the coarse decomposition by excluding some cuspidal data. Moreover, we gave a refined upper bound by controlling the singular hyperplanes in each of the cuspidal data.
The music of the Bohemian literary brotherhoods as preserved in Prague, Narodni Knihovna manuscript PragU XVII B 19.
Creators: name: Barrows, Christine Suzanne Covert.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Music.

description: First copied during the second half of the sixteenth century (and later renewed in 1650), for use by the literary brotherhood of the church of St. Havla in Old Town Prague, the manuscript PragU XVII B 19 belongs to an era of a culture of which many Western musicological scholars have little awareness. The manuscript forms the main subject of this thesis including its physical construction, provenance and musical contents, particularly the polyphonic Czech Credos. In addition this source is placed in the immediate social, cultural and theological context with special emphasis on its place within the larger context of the city of Prague, the kingdom of Bohemia, the monarchical structure of the Habsburg family and the greater conglomerate of the Holy Roman Empire.
2018 Student symposium: Analysis of renewable energy sources at remote locations, 8-12 October 2018, Swinburne University of Technology, Melbourne, Australia
Creators: name: Huda, Durul
name: Rhamdhani, Akbar
Publisher: name: Swinburne
Year: 2024

description: These proceedings contain a collection of selected papers and abstracts from the Student Symposium on Analysis of Renewable Energy Sources at Remote Locations. The symposium was held in conjunction of the delivery of a teaching unit Thermodynamics/Heat Transfer at Swinburne University of Technology at Hawthorn and Sarawak Campus.
Synthesis of Guanidinylated-Substituted Polymers that bind Trans-activation Response Region of Human Immunodeficiency Virus Type-1 RNA
Creators: name: Scott, Shane S.
Publisher: name: Brandeis University
Year: 2013
Subjects: Guanidinylated-Substituted Polymers
HIV-1
Trans-activator of Transcription (Tat)
Trans-activation Response Element (TAR)

description: Multiple targets exist in the development of HIV-1 anti-viral drugs, one of which includes the interaction between the transcriptional activator protein (Tat) and the Trans Activation Response Region (TAR) element of RNA. During transcription, TAR RNA, a 59-base stem-bulge-loop structure, located at the 5’end of all HIV-1 mRNAs, recruits Tat, which modulates viral gene expression in infected cells. Previous experiments have shown that the Arginine Rich Motif (ARM) of Tat is integral for the association of Tat to TAR. Altogether, literature suggests that the inhibition of Tat/TAR RNA interaction is an attractive route to controlling HIV-1 expression and replication. We sought to design synthetic polymers that would disrupt the necessary interaction between Tat and TAR RNA, hindering HIV replication. To target the TAR-RNA, we sought to replicate the basic ARM of Tat by functionalizing amine-amenable polymer scaffolds derived from the Ring-Opening Metathesis Polymerization (ROMP), with the guanidinium derivatives of arginine and agmatine. To this end, we have successfully synthesized the guanidinylated polymers. We hypothesize that by amending the polymer scaffolds with guanidinums, an essential requisite for binding of small molecules to TAR RNA, we may inhibit the mobility shift of the RNA. To test this hypothesis, we assayed the RNA-binding activities of the guanidinylated polymers using an Electrophoretic Mobility Shift Assay (EMSA)—based approach. Our studies indicate that all the synthetic guandiniums are RNA-binding molecules that recognize and retard the mobility of wild-type TAR RNA in a concentration range of 1—400 μM. Additionally, we found that the introduction of magnesium (Mg2+) in the binding buffer strongly stimulates RNA folding as well as increases the RNA-binding specificity of the polymeric compounds. To optimize the binding between the polymers and the RNA we will explore different binding buffers that may increase the binding affinity, allowing us to characterize the Ka and Kd values. In addition, it is expected that TAR-RNA binding molecules may inhibit the association of Tat/TAR; therefore, ongoing work seeks to elucidate the selectivity and specificity of the guanidinum-conjugated polymers, in addition determining the effects of the polymers on protein-TAR RNA interactions by EMSA.
Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer
Creators: name: Hout, David R.
name: Schweitzer, Brock L.
name: Lawrence, Kasey
name: Morris, Stephan W.
name: Tucker, Tracy
name: Mazzola, Rosetta
name: Skelton, Rachel
name: McMahon, Frank
name: Handshoe, John
name: Lesperance, Mary
name: Karsan, Aly
name: Saltman, David L.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Patients with lung cancers harboring an activating anaplastic lymphoma kinase (ALK) rearrangement respond favorably to ALK inhibitor therapy. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are validated and widely used screening tests for ALK rearrangements but both methods have limitations. The ALK RGQ RT-PCR Kit (RT-PCR) is a single tube quantitative real-time PCR assay for high throughput and automated interpretation of ALK expression. In this study, we performed a direct comparison of formalin-fixed paraffin-embedded (FFPE) lung cancer specimens using all three ALK detection methods. The RT-PCR test (diagnostic cut-off ΔCt of ≤8) was shown to be highly sensitive (100%) when compared to FISH and IHC. Sequencing of RNA detected full-length ALK transcripts or EML4-ALK and KIF5B-ALK fusion variants in discordant cases in which ALK expression was detected by the ALK RT-PCR test but negative by FISH and IHC. The overall specificity of the RT-PCR test for the detection of ALK in cases without full-length ALK expression was 94% in comparison to FISH and sequencing. These data support the ALK RT-PCR test as a highly efficient and reliable diagnostic screening approach to identify patients with non-small cell lung cancer whose tumors are driven by oncogenic ALK.
The geography of urban deprivation change in East Montreal and the Montreal urban community: 1986-1996.
Creators: name: Kitchen, Peter F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Geography.

description: In recent years, within the fields of urban geography and urban studies, increasing attention has been paid to the multidimensional concept of urban deprivation. The majority of work on this topic has focused on British and U.S. urban areas with less research directed at Canadian cities. This project made a contribution to the Canadian literature by examining the nature and changing geography of urban deprivation in East Montreal (a section of the central city) and the Montreal Urban Community (MUC) between 1986 and 1996. Essentially, Montreal was selected as a study area because of the significant problems and changes that have occurred in the city over the past several decades. East Montreal contains a number of the city's poorest and most disadvantaged neighbourhoods and as an industrial area was particularly hard hit by the effects of de-industrialization, economic restructuring and recessions during the 1980s and 1990s. The project proposed a model of urban deprivation change, which was applied to the study area to examine its complex and changing social and economic geography. Fourteen indicators of urban deprivation were analyzed at the neighbourhood level (census tracts) in East Montreal and the MUC for three census years---1986, 1991, and 1996. A survey was also conducted in three selected neighbourhoods. The study identified several key trends and findings. There was a significant spreading of urban deprivation and decline during the study period from East Montreal to the remainder of the central city and to several inner suburban municipalities. However, deprivation and decline persisted within East Montreal in the troubled corridor south of Sherbrooke Street. Overall, worsening conditions were more evident during the 1991 to 1996 period compared to the previous five years (1986 to 1991). There was an increase in the level of deprivation among males, particularly with respect to unemployment and poverty. The survey revealed that the majority of respondents were satisfied with their neighbourhoods as a place to live. It also pointed to disparities between census and survey results and suggested that urban deprivation should be considered as more of a relative phenomenon.
The Impact of Pause and Filler Word Encoding on Dementia Detection with Contrastive Learning
Creators: name: Jacks A
name: Guo S
name: Lobaton E
name: Haley K.L
name: Soleimani R
Publisher: name: Multidisciplinary Digital Publishing Institute (MDPI)
Year: 2024

description: Dementia is primarily caused by neurodegenerative diseases like Alzheimer’s disease (AD). It affects millions worldwide, making detection and monitoring crucial. This study focuses on the detection of dementia from speech transcripts of controls and dementia groups. We propose encoding in-text pauses and filler words (e.g., “uh” and “um”) in text-based language models and thoroughly evaluating their impact on performance (e.g., accuracy). Additionally, we suggest using contrastive learning to improve performance in a multi-task framework. Our results demonstrate the effectiveness of our approaches in enhancing the model’s performance, achieving 87% accuracy and an 86% f1-score. Compared to the state of the art, our approach has similar performance despite having significantly fewer parameters. This highlights the importance of pause and filler word encoding on the detection of dementia.
NLP-Methoden in der Klassischen Philologie: Word Embeddings
Creators: name: Beyer, Andrea
name: Schulz, Konstantin
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Classics
subject: Word Embeddings
subject: Representation Learning
subject: Languages and literature
subject: FOS: Languages and literature
subject: Artificial intelligence
subject: Linguistics
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: Folien zu einem Vortrag
Youth intimate partner abuse: relationship conflict among Australian youth
Creators: name: Daff, Elizabeth
Publisher: name: Swinburne
Year: 2024

description: Youth intimate partner abuse is a pervasive issue impacting many adolescents. This thesis provides contemporary figures on the experiences of abusive behaviours in adolescent relationships. It also explores the influence of individual risk markers on perpetration of relationship aggression, and whether these operate in a manner suggested by theory. Findings showed that adolescents were most likely experiencing a combination of abuse victimisation and perpetration in their relationships. Several cognitive constructs influenced this perpetration, however developmentally relevant correlates did not prevent perpetration in an anticipated manner. These results help to inform intervention to reduce perpetration of relationship violence among youth.
Identification of novel in vitro oligonucleotide-primed labelling sites in the DNA of terminally differentiated myeloid cells.
Creators: name: Adcharamoorthy, Yogarany.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Chemistry, Biochemistry.

description: Cells are first embedded in agarose beads, a technique similar to that used in pulse-field-gel electrophoresis. Embedded cells are lysed in situ, subjected to mild alkali treatment and the single-stranded DNA used as template for labelling by the oligonucleotide-primer labelling method. The labelled DNA is then used to probe a battery of genes immobilized on a membrane. As a control, a similar membrane is probed with randomly labelled, completely denatured DNA. Using this new method, I attempted to identify sequences at or near oxyradical-induced breaks in human granulocyte DNA. In human granulocyte DNA, five genes (FOS, CSF2, JUN ERB-B2 and TRF) were found to be 100-1000x more intensely labelled than other genes tested. These sites of labelling were named Selective Labelling Points (SLPs). Further experiments showed that SLPs were present in PMN DNA even in the absence of oxyradical-induced breaks. (Abstract shortened by UMI.)
ҲУҚУҚБУЗАРЛИКЛАРНИНГ ЯККА ТАРТИБДАГИ ПРОФИЛАКТИКАСИНИ АМАЛГА ОШИРИШДА РАСМИЙ ОГОҲЛАНТИРИШ ЧОРА-ТАДБИРИНИНГ ҲУҚУҚИЙ МЕХАНИЗМИНИ ТАКОМИЛЛАШТИРИШ
Creators: name: Вахидов, А.С.
Publisher: name: Zenodo
Year: 2024

description: Мақолада ички ишлар органлари ходимлари томонидан ҳуқуқбузарликлар профилактикасининг якка тартибдаги профилактикаси чора-тадбирининг расмий огоҳлантиришни қўллаш орқали ҳуқуқбузарликларни олдини олишнинг миллий тажрибаси кўриб чиқилган. Муаллиф ички ишлар органлари ходимларининг расмий огоҳлантиришларидан фойдаланиш бўйича амалдаги қонунчиликни такомиллаштириш зарурлигига ишора қилмоқда. Шунингдек, қонуний асослари, уларнинг имкониятларини ўрганилган.
On the Sp_2n-distinguished Automorphic Spectrum of U_2n
Creators: name: Wang, Kewen
Publisher: name: Brandeis University
Year: 2023
Subjects: Automorphic representation
Period

description: In this thesis, we studied the $H$-distinction for the pair $(G,H) = (U_{2n},Sp_{2n})$. We first derived a formula for period integrals of pseudo-Eisenstein series of $U_{2n}$. With the formula, we gave an upper bound of the $H$-distinguished spectrum in terms of the coarse decomposition by excluding some cuspidal data. Moreover, we gave a refined upper bound by controlling the singular hyperplanes in each of the cuspidal data.
title: UNRAVELING THE TANGLES
title: THE IMPACT OF IMPLEMENTATION DIMENSIONS ON PARTICIPANT OUTCOMES SPANNING TREATMENT AND PREVENTION EVIDENCE-BASED PROGRAMS
titleType: Subtitle
Creators: name: Bruzios, Kathryn E.
Publisher: name: Washington State University
Year: 2024
Subjects: Evidence-based programs
treatement
prevention
implementation

description: Evidence-based programs (EBP) have been developed and tested to intervene against the increasing prevalence of mental, emotional, and behavioral (MEB) health problems (e.g., substance use) apparent for individuals across the life span. Moreover, EBPs are comprised of various approaches (i.e., promotion, prevention, treatment, and maintenance) that uniquely address MEB health problems; of interest to this dissertation are prevention and treatment approaches. High quality implementation of EBPs in various settings can be challenging. Implementation research seeks to understand the processes and strategies that work best to help translate and apply EBPs into practice in real world settings. To guide this process, implementation research examines implementation dimensions which indicate implementation success, processes, and serve as key outcomes. Moreover, implementation dimensions (e.g., fidelity, quality, adaptation, and responsiveness) can be used to predict participant outcomes. Despite extensive theory and research that highlights these relationships, more research is needed to understand how multiple implementation dimensions interact to predict participant outcomes. This dissertation consists of three manuscripts which examined the relationship between implementation dimensions and MEB health outcomes across treatment and prevention. Taken together, these three manuscripts aim to a) conduct two empirical studies to contribute to the literature examining implementation dimensions’ impact on participant outcomes (Manuscripts 1 and 2), and b) review dissemination and implementation literature to determine gaps in the guiding model (Manuscript 3). Together, these manuscripts illustrate the complexity of implementation research, the variations in relationships between implementation dimensions and participant outcomes, and highlights critical next steps for the field.
DATA AUGMENTATION AND NEURAL NETWORK MODELS CONSTRUCTION FOR HAND-WRITTEN CHARACTER RECOGNITION IN BIOMETRIC AUTHENTICATION SYSTEMS
Creators: name: Anastasia Gennadevna Isaeva, Alexey Sergeevich Katasev
Publisher: name: TuEngr Group
Year: 2019
Subjects: biometric identification
Augmented ANN
Distorted handwriting
Numeric handwriting
Training ANN.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 10, 13, 10A13C: 1-8
The Projectile Point Sequences in the Puget Sound Region
Creators: name: Croes, Dale R.
name: Williams, Scott R.
name: Ross, Larry
name: Collard, Mark
name: Dennler, Carolyn
name: Vargo, Barbara
Publisher: name: Washington State University
Year: 2008
Subjects: Archaeology

description: The research area discussed in this chapter encom­passes what is considered to be the traditional territory of the Lushootseed speaking Coast Salish People, who are sometimes referred to as the Puget Sound Salish (e.g., Thompson and Kinkade 1990:38; Suttles and Lane 1990:485-502).1bis area begins at Samish Bay, east of the San Juan Islands, and extends southward to the head of Puget Sound, and includes the watersheds of numerous streams and rivers that drain from the Cascade Foothills into Puget Sound (Figure 1). Comparatively speaking, few systematic ar­chaeological investigations have occurred in this part of the Pacific Northwest, so this paper should be considered a preliminary but much needed syn­thesis of over 4500 square miles of sheltered "inside" areas between the Olympic and Cascade mountain ranges. The chipped stone projectile point sequence we will present covers the known sequence of lithic traditions in the study area, ranging from the Clovis period (approximately 11,000 BP) through to the time of European colonization.
title: British Indie Music in the 1990s: Public Spheres, Media and Exclusion
Creators: name: White, Rachel
Publisher: name: Goldsmiths, University of London
Year: 2006

description: Developing existing theories of public and counterpublic spheres, this thesis moves beyond theoretical ideals to formulate a working model of the cultural counterpublic sphere in which British indie music is understood, legitimated and ascribed value. This 'indie public' is then interrogated with the central aim of understanding the continued discrepancy in levels of male and female participation in British indie music at every level during the 1990s. Given the centrality of the media to contemporary, geographically dispersed publics it is through a discursive analysis of the British music press, particularly the NME and the Melody Maker, that the masculine constitution of the indie public is revealed. The music press is viewed as not just representing or reflecting the indie scene, but as central to its construction as a genre and the discursive production of privileged subject positions therein. The empirical research analyses how discourses of gender, and to a lesser extent race, class and sexuality, inform the key themes and concepts through which the music press both constructs and evaluates artists and audiences in the indie public. The bulk of the analysis focuses the extended coverage of four prominent 90s' indie bands; Suede, Elastica, Oasis, and Echobelly. The findings are presented thematically in four main areas; the construction of authenticity and 'the artist', the construction of stars and the bases of their appeal, the importance of British national identity during the 'Britpop' era of the mid-1990s and the production of fans and audiences in the indie public. The research proposes that these themes are interlinked, intrinsically gendered and productive of a profoundly male homosocial sphere from which women are largely excluded.
Genetic diversity in puroindolines and grain softness proteins in Australian and overseas wheat germplasm and implications for grain texture
Creators: name: Pickering, Paul Anthony
Publisher: name: Swinburne
Year: 2024

description: Grain hardness in the hexaploid wheat species Triticum aestivum is one of the most important factors determining end-use quality and commercial value of the world trade of wheat. While mutations in the two puroindoline genes have been associated with grain hardness, there is insufficient understanding regarding genetic factors associated with grain texture. This investigation resulted in the identification of: limited puroindoline diversity present in Australian hard wheat germplasm; potential variation and diversity of the puroindoline genes in overseas landraces and the polyploid wheats; the diverse variation in sequence and gene copy number of the Gsp-1 genes which have potential for a similar structure and role as the grain hardness related puroindolines genes.
A model for assessing the environmental impact of transport
Creators: name: ŁATUSZYŃSKA, Małgorzata M.
name: STRULAK-WÓJCIKIEWICZ, Roma
Publisher: name: Wrocław University of Technology, Wrocław University of Economics, Polish Operational and Systems Research Society
Year: 2013
Subjects: transport, environment, computer simulation

description: OPERATIONS RESEARCH AND DECISIONS; ISSN 2081-8858
A semi-Markov model of the variability of power generation from renewable sources
Creators: name: MALINOWSKI, Jacek
Publisher: name: Wrocław University of Technology, Wrocław University of Economics, Polish Operational and Systems Research Society
Year: 2013
Subjects: renewable power generation, forecasting of environmental conditions, semi-Markov modeling, Laplace transform

description: OPERATIONS RESEARCH AND DECISIONS; ISSN 2081-8858
ANALYSIS THE ROLE OF ARTIFICIAL INTELLIGENCE IN THE CUSTOMER CARE SERVICE OF ISLAMI BANK BANGLADESH PLC USING TAM
Creators: name: Samira Binte Saif
Publisher: name: Zenodo
Year: 2024

description: Customer care service is one of the most time-consuming activities for a bank. In a customer care service of a bank, customers asked questions which are basic and simple to solve. With the help of Artificial Intelligence system bank can develop a recorded conversation system that analyzes customer information and automatically proceeds with service. The chatbot of bank customer care is based on Artificial Intelligence, the robot is able to identify answer of the questions   and further improve the service that was already facilitated before. The customer care service of Islami Bank Bangladesh PLC is serving 24/7 a day. This paper explain how AI help to perform customer care service of IBB PLC smoothly. The research show that how AI help to bond an emotional connection between Islami Bank Bangladesh PLC and it’s customers by customer care service.
Comparison of treatment response, remission rate and drug adherence in polyarticular juvenile idiopathic arthritis patients treated with etanercept, adalimumab or tocilizumab
Creators: name: Horneff, Gerd
name: Klein, Ariane
name: Klotsche, Jens
name: Minden, Kirsten
name: Huppertz, Hans-Iko
name: Weller-Heinemann, Frank
name: Kuemmerle-Deschner, Jasmin
name: Haas, Johannes-Peter
name: Hospach, Anton
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Adalimumab
subject: Etanercept
subject: Tocilizumab
subject: Juvenile idiopathic arthritis
subject: Drug surveillance
subject: JADAS
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Treatment response, remission rates and compliance in patients with polyarticular juvenile idiopathic arthritis (polyJIA) treated with adalimumab, etanercept, or tocilizumab were analyzed in clinical practice. Methods Data collected in the German BIKER registry were analyzed in patients with polyJIA who started treatment with approved biologics, adalimumab, etanercept or tocilizumab, from 2011 to 2015. Baseline patient characteristics, treatment response, safety and drug survival were compared. Results Two hundred thirty- six patient started adalimumab, 419 etanercept and 74 tocilizumab, with differences in baseline patient characteristics. Baseline Juvenile Disease Activity Score (JADAS)10 (mean ± SD) in the adalimumab/etanercept/tocilizumab cohorts was 12.1+/−7.6, 13.8 ± 7.1 and 15.1 ± 7.4, respectively (adalimumab vs etanercept, p = 0.01), and Childhood Health Assessment Questionnaire (CHAQ)-disability index scores was 0.43 ± 0.58, 0.59 ± 0.6 and 0.63 ± 0.55, respectively (adalimumab vs etanercept, p
Progesterone in women with arrested premature labor, a report of a randomised clinical trial and updated meta-analysis
Creators: name: Wood, Stephen
name: Rabi, Yacov
name: Tang, Selphee
name: Brant, Rollin
name: Ross, Susan
Publisher: name: BioMed Central
Year: 2017

description: Background: Progesterone may be effective in prevention of premature birth in some high risk populations. Women with arrested premature labor are at risk of recurrent labor and maintenance therapy with standard tocolytics has not been successful. Methods: Randomized double blinded clinical trial of daily treatment with 200 mg vaginal progesterone in women with arrested premature labor and an updated meta-analysis. Results: The clinical trial was terminated early after 41 women were enrolled. Vaginal progesterone treatment did not change the median gestational age at delivery: 36+2 weeks versus 36+4 weeks, p = .865 nor increase the mean latency to delivery: 44.5 days versus 46.6 days, p = .841. In the updated meta-analysis, progesterone treatment did reduce delivery <37 weeks gestation and increase latency to delivery, but this treatment effect was not evident in the high quality trials: (OR 1.23, 95% CI 0.91, 1.67) and (−0.95 days, 95% CI −5.54, 3.64) respectively. Conclusion: Progesterone is not effective for preventing preterm birth following arrested preterm labor.
Les bibliothèques universitaires, au service d'un monde durable
Creators: name: Ghaouti, Loubna
name: Bourque, Marilou
Publisher: name: Université Laval
Year: 2024
Subjects: Accès à la connaissance (Mouvement)
Développement durable
Bibliothèques universitaires

description: Présentation de Loubna Ghaouti, directrice générale de la Bibliothèque de l'Université Laval, lors de l'École d'été de l'AIFBD - 8e édition - SIEL. Cet échange a eu lieu lors de la Table ronde - L'accès à l'information comme pilier des objectifs de développement durable. La présentation a été co-rédigée par Marilou Bourque, bibliothécaire spécialisée en éducation ouverte, et validée par différents collègues de la bibliothèque. 
description: Ressources éducatives libres

Open educational resources

REL

OER
description: Discipline : Autre

Format : Texte

Type de la ressource : Objet d'apprentissage

Type de matériel pédagogique : Présentation
Comprehensive Small RNA-Seq of Adeno-Associated Virus (AAV)-Infected Human Cells Detects Patterns of Novel, Non-Coding AAV RNAs in the Absence of Cellular miRNA Regulation
Creators: name: Stutika, Catrin
name: Mietzsch, Mario
name: Gogol-Doering, Andreas
name: Weger, Stefan
name: Sohn, Madlen
name: Chen, Wei
name: Heilbronn, Regine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::576 Genetik und Evolution
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Most DNA viruses express small regulatory RNAs, which interfere with viral or cellular gene expression. For adeno-associated virus (AAV), a small ssDNA virus with a complex biphasic life cycle miRNAs or other small regulatory RNAs have not yet been described. This is the first comprehensive Illumina-based RNA-Seq analysis of small RNAs expressed by AAV alone or upon co-infection with helper adenovirus or HSV. Several hotspots of AAV-specific small RNAs were detected mostly close to or within the AAV-ITR and apparently transcribed from the newly identified anti-p5 promoter. An additional small RNA hotspot was located downstream of the p40 promoter, from where transcription of non- coding RNAs associated with the inhibition of adenovirus replication were recently described. Parallel detection of known Ad and HSV miRNAs indirectly validated the newly identified small AAV RNA species. The predominant small RNAs were analyzed on Northern blots and by human argonaute protein-mediated co-immunoprecipitation. None of the small AAV RNAs showed characteristics of bona fide miRNAs, but characteristics of alternative RNA processing indicative of differentially regulated AAV promoter-associated small RNAs. Furthermore, the AAV-induced regulation of cellular miRNA levels was analyzed at different time points post infection. In contrast to other virus groups AAV infection had virtually no effect on the expression of cellular miRNA, which underscores the long-established concept that wild-type AAV infection is apathogenic.
title: Switching between hands in a serial reaction time task
title: a comparison between young and old adults
titleType: Subtitle
Creators: name: Hoff, Maike
name: Trapp, Sabrina
name: Kaminski, Elisabeth
name: Sehm, Bernhard
name: Steele, Christopher J.
name: Villringer, Arno
name: Ragert, Patrick
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: motor skill learning, aging
subject: hand switch costs
subject: bimanual serial reaction time task
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Healthy aging is associated with a variety of functional and structural brain alterations. These age-related brain alterations have been assumed to negatively impact cognitive and motor performance. Especially important for the execution of everyday activities in older adults (OA) is the ability to perform movements that depend on both hands working together. However, bimanual coordination is typically deteriorated with increasing age. Hence, a deeper understanding of such age-related brain-behavior alterations might offer the opportunity to design future interventional studies in order to delay or even prevent the decline in cognitive and/or motor performance over the lifespan. Here, we examined to what extent the capability to acquire and maintain a novel bimanual motor skill is still preserved in healthy OA as compared to their younger peers (YA). For this purpose, we investigated performance of OA (n = 26) and YA (n = 26) in a bimanual serial reaction time task (B-SRTT), on two experimental sessions, separated by 1 week. We found that even though OA were generally slower in global response times, they showed preserved learning capabilities in the B-SRTT. However, sequence specific learning was more pronounced in YA as compared to OA. Furthermore, we found that switching between hands during B-SRTT learning trials resulted in increased response times (hand switch costs), a phenomenon that was more pronounced in OA. These hand switch costs were reduced in both groups over the time course of learning. More interestingly, there were no group differences in hand switch costs on the second training session. These results provide novel evidence that bimanual motor skill learning is capable of reducing age- related deficits in hand switch costs, a finding that might have important implications to prevent the age-related decline in sensorimotor function.
Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measured with EEG and fMRI
Creators: name: Nierhaus, Till
name: Pach, Daniel
name: Huang, Wenjing
name: Long, Xiangyu
name: Napadow, Vitaly
name: Roll, Stephanie
name: Liang, Fanrong
name: Pleger, Burkhard
name: Villringer, Arno
name: Witt, Claudia M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Acupuncture can be regarded as a complex somatosensory stimulation. Here, we evaluate whether the point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in healthy volunteers. We used EEG, event-related fMRI, and resting-state functional connectivity fMRI to assess neural responses to standardized needle stimulation of the acupuncture point ST36 (lower leg) and two control point locations (CP1 same dermatome, CP2 different dermatome). Cerebral responses were expected to differ for stimulation in two different dermatomes (CP2 different from ST36 and CP1), or stimulation at the acupuncture point vs. the control points. For EEG, mu rhythm power increased for ST36 compared to CP1 or CP2, but not when comparing the two control points. The fMRI analysis found more pronounced insula and S2 (secondary somatosensory cortex) activation, as well as precuneus deactivation during ST36 stimulation. The S2 seed-based functional connectivity analysis revealed increased connectivity to right precuneus for both comparisons, ST36 vs. CP1 and ST36 vs. CP2, however in different regions. Our results suggest that stimulation at acupuncture points may modulate somatosensory and saliency processing regions more readily than stimulation at non-acupuncture point locations. Also, our findings suggest potential modulation of pain perception due to acupuncture stimulation.
La atrición de la competencia morfosintáctica del español lengua materna en situación de contacto con el inglés.
Creators: name: Cuza Blanco, Alejandro.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Language, Modern.

description: First language attrition is the temporary or permanent loss of first language competence as reflected in the incorrect use of native grammatical principles or in the speaker's inability to make grammaticality judgments that would be consistent with that of monolingual native speakers (Seliger y Vago, 1991; De Bot y Weltens, 1991; Seliger, 1996). Our study centers on L1 (Spanish) attrition of four constructions related to three syntactic issues: (1) the so-called 'Compounding Parameter' (resultative constructions and Noun-Noun compound formation); (2) the "Verb Movement Parameter" as it determines the position of subjects in Spanish and English interrogative constructions; (3) the speck characteristics of Spanish clitic pronouns. We analyze the influence of linguistic as well as sociolinguistic factors in the erosion of these grammatical structures among Spanish immigrants. The data reveal, among other things, that the age of contact with the second language is a determining factor in the process of language attrition, as it is in the process of language acquisition. We also argue that the process of attrition of the native's morphosyntax occurs locally and is not generalized across all morphosyntactic structures. As in the case of second language acquisition, there is no dramatic change of native parameters.
EFFECTIVENESS IN COMMUNICATIVE LANGUAGE TEACHING APPROACHES
Creators: name: Shermatov, Fayzullo
name: Azimova, Sevara
Publisher: name: Zenodo
Year: 2024

description: This article provides a comprehensive examination of Communicative Language Teaching (CLT) approaches, focusing on their effectiveness in promoting language proficiency through authentic communication and learner-centered instruction. Through an exploration of CLT principles, methods, and empirical evidence, it sheds light on the transformative impact of CLT on language learning outcomes.
Does Feedback-Related Brain Response during Reinforcement Learning Predict Socio-motivational (In-)dependence in Adolescence?
Creators: name: Raufelder, Diana
name: Boehme, Rebecca
name: Romund, Lydia
name: Golde, Sabrina
name: Lorenz, Robert C.
name: Gleich, Tobias
name: Beck, Anne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: fMRI
subject: reinforcement learning
subject: motivation
subject: social relationships in school
subject: 100 Philosophie und Psychologie::150 Psychologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: This multi-methodological study applied functional magnetic resonance imaging to investigate neural activation in a group of adolescent students (N = 88) during a probabilistic reinforcement learning task. We related patterns of emerging brain activity and individual learning rates to socio-motivational (in-)dependence manifested in four different motivation types (MTs): (1) peer- dependent MT, (2) teacher-dependent MT, (3) peer-and-teacher-dependent MT, (4) peer-and-teacher-independent MT. A multinomial regression analysis revealed that the individual learning rate predicts students’ membership to the independent MT, or the peer-and-teacher-dependent MT. Additionally, the striatum, a brain region associated with behavioral adaptation and flexibility, showed increased learning-related activation in students with motivational independence. Moreover, the prefrontal cortex, which is involved in behavioral control, was more active in students of the peer-and-teacher- dependent MT. Overall, this study offers new insights into the interplay of motivation and learning with (1) a focus on inter-individual differences in the role of peers and teachers as source of students’ individual motivation and (2) its potential neurobiological basis.
The utility of gaze entropy measures in estimating visual scanning efficiency to detect driver impairment
Creators: name: Shiferaw, Brook
Publisher: name: Swinburne
Year: 2024

description: Driver monitoring technologies are increasingly becoming available in new vehicles and as stand alone devices. Yet, their utility is limited to specific symptoms of impairing conditions such as drowsiness and looking away from the road. The present thesis investigated how gaze data from driver monitoring technologies can be used to infer internal cognitive impairment. The results presented herein indicate that such technology may be used to detect impairment in real-time and alert drivers, which may help reduce traffic accidents.