cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Tacticity effects on conformational structure and hydration of poly-(methacrylic acid) in aqueous solutions-a molecular dynamics simulation study
Creators: name: Abhishek K. Gupta
name: Upendra Natarajan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Hematology
subject: Computational Biology

description: The influence of tacticity on chain dimensions, backbone and side-group conformational states and relaxation dynamics, intermolecular hydrogen bonding and its relaxation dynamics was investigated for 30 repeat unit poly(methacrylic acid) (PMA) as a function of the degree-of-neutralisation, f (i.e. charge density) [0 f + neutralising counter-ions, using molecular dynamics simulations. Chain expansion with increase in charge density is observed. Simulation results, where applicable, compare well with experimental results in the literature. Isotactic (i-PMA) chain exhibits the largest expansion (89% change in Rg), and syndiotactic (s-PMA-RR-0.7) chain shows 31%. For fully neutralised chain (high charge density), the probability for trans conformation at backbone bonds follows the trend i-PMA > a-PMA > s-PMA. At high charge density, a higher probability of trans state is obtained at meso dyads as compared to racemic dyads and the side group in i-PMA relative to other tacticity is conformationally more extended. RR triads impart better hydrogen bonding with water. In the COOH side group, greater rotational mobility is observed for i-PMA as compared to s-PMA. Water coordination to PMA is invariant with tacticity at low f. For f = 1, s-PMA exhibits the best level of H-bonding, due to its 3D chemical structural configuration. Binding distance between water and PMA atoms and their coordination number remain unchanged with respect to ionisation of COOH groups. Isotactic (i-PMA) exhibits the fastest relaxation of polymer-water H-bonds. While counter-ion coordination on to PMA is unaffected by tacticity, the intensity of ion condensation as well as hydrogen bond relaxation time at f = 1 varies in the order i-PMA > a-PMA > s-PMA.
Joint Reflection and Power Splitting Optimization for RIS-assisted OAM-SWIPT
Creators: name: Lyu, Runyu
name: Cheng, Wenchi
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Simultaneous wireless information and power transfer (SWIPT) can enhance the spectrum and power efficiencies of wireless communications networks. Line-of-sight (LOS) transmission is a typical SWIPT scenario. However, the strong channel correlation limits the spectrum and energy efficiencies of SWIPT in the LOS channel. Due to the orthogonal wavefronts, orbital angular momentum (OAM) waves can facilitate the SWIPT in LOS channels. With the assistance of the reconfigurable intelligent surface (RIS), both the energy efficiency and capacity can be further improved for the OAM-SWIPT systems. In this paper, we model the RIS-assisted OAM-SWIPT transmission and derive the optimal reflection coefficients and power splitting ratio for it. We first give the system and channel models. Then, we propose the transmission scheme. Based on the transmission scheme, we formulate the capacity and energy harvesting (EH) trade-off problem. We solve the problem by developing an alternating optimization algorithm. Simulations validate the capacity and EH enhancements brought by the RIS for OAM-SWIPT.
description: 6 pages, 5 figures
Understanding Community Broadband: The Alberta Broadband Toolkit (2023 Ed.)
Creators: McNally, Michael B.
McMahon, Rob
Rathi, Dinesh
Sieben, Julia
Publisher: name: University of Alberta Library
Year: 2023

Understanding Community Broadband: The Community Broadband Toolkit (2023 Ed.) has been designed for use by Alberta communities to assist in developing broadband solutions. The 2023 Toolkit updates and expands on the original 2016 version. The toolkit is organized into three general sections - learning about broadband, thinking about broadband, and planning broadband. Together these sections aim to identify the key knowledge and actionable steps that a community and its leaders can use to develop and achieve local broadband solutions. The toolkit also contains case examples of broadband solutions from communities across the province. The Toolkit was originally made possible by funding from the Government of Alberta - Economic Development and Trade; the 2023 edition was made possible by Mitacs Accelerate Internship in partnership with the Rural Development Network.
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation
Creators: name: Rein, Idun Dale
name: Landsverk, Kirsti Solberg
name: Micci, Francesca
name: Patzke, Sebastian
name: Stokke, Trond
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: PARP inhibitors have been approved for treatment of tumors with mutations in or loss of BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in synthetic lethality are not well understood and varying clinical responses have been observed. We have investigated the dose- and time-dependency of cell growth, cell death and cell cycle traverse of 4 malignant lymphocyte cell lines treated with the PARP inhibitor Olaparib. PARP inhibition induced a severe growth inhibition in this cell line panel and increased the levels of phosphorylated H2AX-associated DNA damage in S phase. Repair of the remaining replication related damage caused a G2 phase delay before entry into mitosis. The G2 delay, and the growth inhibition, was more pronounced in the absence of functional ATM. Further, Olaparib treated Reh and Granta-519 cells died by apoptosis, while U698 and JVM-2 cells proceeded through mitosis with aberrant chromosomes, skipped cytokinesis, and eventually died by necrosis. The TP53-deficient U698 cells went through several rounds of DNA replication and mitosis without cytokinesis, ending up as multinucleated cells with DNA contents of up to 16c before dying. In summary, we report here for the first time cell cycle-resolved DNA damage induction, and cell line-dependent differences in the mode of cell death caused by PARP inhibition.
Presentation of the Sweden National Chapter at the CoARA National Chapters Exchange Forum 2024
Creators: name: Jönsson, Jan-Ingvar
Publisher: name: Zenodo
Year: 2024

description: Slides presented at the CoARA National Chapters Exchange Forum 2024.  A description of the event is available here: https://coara.eu/news/building-a-stronger-network-coara-national-chapters-convene-for-a-first-exchange-forum/.
OAM-SWIPT for IoE-Driven 6G
Creators: name: Lyu, Runyu
name: Cheng, Wenchi
name: Shen, Bazhong
name: Ren, Zhiyuan
name: Zhang, Hailin
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Simultaneous wireless information and power transfer (SWIPT), which achieves both wireless energy transfer (WET) and information transfer, is an attractive technique for future Internet of Everything (IoE) in the sixth-generation (6G) mobile communications. With SWIPT, battery-less IoE devices can be powered while communicating with other devices. Line-of-sight (LOS) RF transmission and near-field inductive coupling based transmission are typical SWIPT scenarios, which are both LOS channels and without enough degree of freedom for high spectrum efficiency as well as high energy efficiency. Due to the orthogonal wavefronts, orbital angular momentum (OAM) can facilitate the SWIPT in LOS channels. In this article, we introduce the OAM-based SWIPT as well as discuss some basic advantages and challenges for it. After introducing the OAM-based SWIPT for IoE, we first propose an OAM-based SWIPT system model with the OAM-modes assisted dynamic power splitting (DPS). Then, four basic advantages regarding the OAM-based SWIPT are reviewed with some numerical analyses for further demonstrating the advantages. Next, four challenges regarding integrating OAM into SWIPT and possible solutions are discussed. OAM technology provides multiple orthogonal streams to increase both spectrum and energy efficiencies for SWIPT, thus creating many opportunities for future WET and SWIPT researches.
description: 7 pages, 6 figures
Understanding intracellular trafficking and endosomal escape of macromolecules
Creators: name: Teo, Serena Lee Yong
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: This thesis describes a new method for studying the efficiency of large molecules entering cells. It demonstrates the low efficiency of various large molecules at entering cells and established that other materials may help improve their ability to enter cells.
Limited extension after linked total elbow arthroplasty in patients with rheumatoid arthritis
Creators: name: Ogino, Hiroko
name: Hiromu Ito
name: Moritoshi Furu
name: Ishikawa, Masahiro
name: Yoshitomi, Hiroyuki
name: Matsuda, Shuichi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Objective: Total elbow arthroplasty (TEA) has become an established procedure to relieve pain and to increase the range of motion of the destructed elbow in patients with rheumatoid arthritis (RA). However, some patients still have limited extension after TEA, and the causes of limited extension after TEA have yet to be elucidated. Methods: To examine whether widening of the joint space can cause such limited extension, we retrospectively analyzed 55 cases of linked TEA in patients with RA. There were seven male and 40 female with a mean age of 63.8 years (range, 30–80 years) and a mean follow-up of 7.5 ± 4.2 years (range, 2.5–15.6 years). The Mayo Elbow Performance Score (MEPS) and radiological measurements were recorded. Widening of the joint space was calculated by subtracting the length measured on postoperative radiograph from preoperative radiograph. Results: MEPS and range of motion were significantly improved after surgery except for extension. The degree of extension was significantly correlated with radiological widening of the joint space in the limited extension group. Correlation analyses showed that postoperative limited extension was correlated with lower MEPS daily function. Conclusions: Limited extension after linked TEA is partly derived from perioperative widening of the joint space and potentially limits daily function in patients with RA.
OLIY O'QUV YURTLARIDA IDEAL GAZ QONUNLARINI "INTELLEKT XARITA" METODIDAN FOYDALANISHNING SAMARADORLIGI
Creators: name: Raxmanov, Valijon
name: Mamatkabilova, Matlyuba
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada oliy o‘quv yurtlarida ideal gaz qonunlari bo‘yicha ta’lim jarayonida “Intellekt xarita” metodining samaradorligi o‘rganiladi. Mavzu talabalar uchun tez-tez murakkab bo‘lib, an'anaviy metodlar orqali barcha kerakli tushunchalarni o‘zlashtirish qiyin bo‘lishi mumkin. “Intellekt xarita” metodi talabalarga murakkab ilmiy kontseptlarni vizual ravishda taqdim etib, o‘rganish jarayonini soddalashtirish va eslab qolishni osonlashtirishda katta yordam beradi. Maqolada ushbu metodning ta’lim sifatini yaxshilashdagi roli va uning amaliy ahamiyati ko‘rsatiladi.
Will Europe be forged in crises? The impact of the Covid-19 and Ukraine crises on EU actorness
Creators: name: Eisl, Andreas
name: Rubio, Eulalia
Publisher: name: Zenodo
Year: 2024
Subjects: EU actorness
Covid-19 crisis
global energy crisis
global food crisis
public procurement
development aid

description: In this paper, we study the effect of crises on EU actorness, defined as the EU’s capacity to defend its interests and values at the global level. Our research focuses on two major crises, the Covid-19 crisis and the 2022 Russian invasion of Ukraine. Drawing on a process-tracing approach, we analyse four of the Union’s policy initiatives that were proposed, negotiated and implemented to respond to these crises: joint vaccine procurement, common gas purchases, and the COVAX and FARM initiatives. The paper assesses the outcomes of these four initiatives and discusses the extent to which these initiatives led to the development of EU actorness and the achievement of common objectives. The analysis identifies the degree of internal cohesion, and how it is influenced by specific crises, as a key factor in fostering or hampering EU actorness in different policy fields. It also shows that the formal distribution of competences between the EU and the member states in specific policy areas matters little in crisis times, as the EU can resort to emergency competences in such situations. The findings of this paper contribute to the literature on EU actorness and equally provide some insights on policy legacies and learning.
Valorization of rendering industry wastes and co-products for industrial chemicals, materials and energy: review
Creators: name: Tizazu Mekonnen
name: Mussone, Paolo
name: Bressler, David
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Microbiology
subject: Biochemistry

description: Over the past decades, strong global demand for industrial chemicals, raw materials and energy has been driven by rapid industrialization and population growth across the world. In this context, long-term environmental sustainability demands the development of sustainable strategies of resource utilization. The agricultural sector is a major source of underutilized or low-value streams that accompany the production of food and other biomass commodities. Animal agriculture in particular constitutes a substantial portion of the overall agricultural sector, with wastes being generated along the supply chain of slaughtering, handling, catering and rendering. The recent emergence of bovine spongiform encephalopathy (BSE) resulted in the elimination of most of the traditional uses of rendered animal meals such as blood meal, meat and bone meal (MBM) as animal feed with significant economic losses for the entire sector. The focus of this review is on the valorization progress achieved on converting protein feedstock into bio-based plastics, flocculants, surfactants and adhesives. The utilization of other rendering streams such as fat and ash rich biomass for the production of renewable fuels, solvents, drop-in chemicals, minerals and fertilizers is also critically reviewed.
Exploring and Characterizing the Endonuclease of Porcine Circovirus Type 2 (PCV2)
Creators: name: Ngnepieba, Maxance
name: Bertozzi, Carolyn
Publisher: name: Stanford Digital Repository
Year: 2025
Subjects: subject: Endonuclease
subject: Virus diseases
subject: DNA Cleavage
subject: Biology
subject: Gel Electrophoresis

description: This study delves into the activities and substrate specificities of Porcine Circovirus Type 2 (PCV2) endonucleases, shedding light on their structural and functional characteristics. Through a targeted approach, we expressed and purified both wild-type PCV2 and a catalytically inactive mutant (dPCV), facilitating a comparative analysis of their reactivities with single-stranded DNA (ssDNA). Our findings reveal that while PCV2 adeptly cleaves increasing concentrations of ssDNA, dPCV2 exhibits no cleavage activity, highlighting the critical role of the catalytic tyrosine residue in PCV2 endonuclease’s function. Further exploration using truncated ssDNA oligonucleotides and mutagenesis analysis unveils the intricate relationship between sequence variations and activity, providing insights into substrate recognition and cleavage efficiency. Additionally, our investigation into PCV2-GFP's reactivity with double-stranded DNA (dsDNA) demonstrates a specific preference for ssDNA substrates, underscoring its specialized role in recognizing and cleaving single-stranded nucleic acids. These findings advance our understanding of PCV2 endonucleases, offering valuable insights into their biological significance and potential applications in viral biology.
Creating a Novel Liquid Biopsy Using Exosomes: A Platform for Immunological Biomarker Discovery
Creators: name: Scala, Jack
name: Snyder, Michael
name: Frank, Matthew
Publisher: name: Stanford Digital Repository
Year: 2025
Subjects: subject: Immunotherapy--Complications
subject: Exosomes
subject: Biomarkers

description: Chimeric Antigen Receptor (CAR) T cell therapies have proven efficacious for patients with chemotherapy-refractory cancers. However, due to the transactivation of various immune cells and the development of a hyper-inflammatory disease state, many patients experience life-threatening complications post-CAR-T cell therapy, such as immune effector cell associated neurotoxicity syndrome (ICANS), immune effector cell associated hemophagocytic lymphohistiocytosis (IEC-HS), and cytokine release syndrome (CRS). There is a strong clinical need to identify robust biomarkers that enable the early diagnosis and treatment of this emerging class of immune-effector induced conditions. In this thesis, I propose a novel platform for the identification of robust and specific immune-cell-related biomarkers using exosomes, a subclass of extracellular vesicles, isolated from patient plasma samples. Specifically, the present work aims to develop and characterize a novel liquid biopsy capable of isolating T-cell, natural killer cell, and macrophage derived exosomes from a 1 mL sample of plasma, which is feasibly implementable in clinical workflows. By characterizing the isolated morphology, size range, and protein contents of isolated vesicles, I demonstrate that my proposed method isolates exosomes with greater purity than current isolation methods, including ultracentrifugation and size exclusion chromatography, and serves as a feasible method of identifying cytokine cargo in exosomes. With further optimization, we expect this can be developed into a potential clinical test of immune-effector adverse conditions.
Modeling and Performance Analysis of OAM-NFC Systems
Creators: name: Lyu, Runyu
name: Cheng, Wenchi
name: Zhang, Wei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Due to its low energy consumption and simplicity, near field communication (NFC) has been extensively used in various short-range transmission scenarios, for example, proximity payment and NFC entrance guard. However, the low data rate of NFC limits its application in high rate demanded scenarios, such as high-resolution fingerprint identification and streaming media transmission as well as the future promising high rate indoor communications among pads, phones, and laptops. In this paper, we model and analyze the performance of the orbital angular momentum based NFC (OAM-NFC) system, which can significantly increase the capacity of NFC. We first give the OAM system model. With coils circularly equipped at the transmitter and receiver, OAM-NFC signals can be transmitted, received, and detected. Then, we develop the OAM-NFC generation and detection schemes for NFC multiplexing transmission. We also analyze the OAM-NFC channel capacity and compare it with those of single-input-single-output (SISO) as well as multi-input-multi-output (MIMO) NFC. Simulation results validate the feasibility and capacity enhancement of our proposed OAM-NFC system. How different variables, such as the transceiver misalignment, the numbers of transceiver coils, and transceiver distance, impact the OAM-NFC capacity are also analyzed.
description: 14 pages, 13 figures
GDI Deliverable D6.2: Report on European resources and data suitable for inclusion into the GDI
Creators: name: Perola, Markus
name: Hiekkalinna, Tero
Publisher: name: Zenodo
Year: 2024
Subjects: GDI
European Genomic Data Infrastructure
1+MG
1+Million Genomes Initiative
B1MG
Data
European resources

description: This report outlines the contributions of European countries to the Genomic Data Infrastructure (GDI), specifying the expected number of samples, the mix of legacy Whole Genome Sequences (WGS) and new DNA samples, sequencing technologies used, and the infrastructure for managing, storing, and sequencing these samples.

Work AccomplishedBelow we detail the potential national legacy contributions to the GDI. The work was done with collaboration with the Genome of Europe - initiative (GoE) utilising its questionnaire with comparison to previously collected data. This was done partly for the reason to avoid overlapping sets of questions being sent to the same people during the same time period which probably would have decreased the response frequency for both related efforts.

Data from 27 European countries has been aggregated, while only two countries provided no answers for the GoE questionnaire. These contributions include both legacy WGS, which some of may require reconsenting, and potential newly collected DNA or to be collected samples specifically for 1+MG and GoE. The report highlights the use of both short-read and long-read sequencing technologies across different countries, with work involving a range of biobanks, research institutes, and academic institutions. The capacities for sequencing and data processing vary, with some countries outsourcing these tasks due to limited local capacity.
SILVIA DI GASPARE, Demografia dei conflitti armati. I casi del Ruanda e della Bosnia, Aracne Editrice, Canterano, 2018
Creators: name: García-Pereiro, Thaís
Publisher: name: Euro-Balkan Law and Economics Review
Year: 2020

description: Euro-Balkan Law and Economics Review, N. 1 (2020): Fascicolo 1
Nonlinear modal analysis of frames
Creators: name: Sheikh, Tauqir Muhammad, 1954-
Publisher: name: The University of Texas at Austin
Year: 1980
Subjects: subject: Structural analysis (Engineering)
subject: Structural frames

description: The intent of this study is to formulate a solution scheme for the nonlinear dynamic analysis of framed structures, which yields results about as accurate as those obtained using explicit formulae but still are not more expensive than the implicit shemes, for structures of practically any stiffness. That is, the stability of the scheme is not controlled by those higher modes of the structure which have very insignificant contribution to the overall response
Generalized TEMOM Scheme for Solving the Population Balance Equation
Creators: name: Mingzhou Yu
name: Yueyan Liu
name: Jianzhong Lin
name: Seipenbusch, Martin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biophysics
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Physiology
subject: Microbiology

description: This article proposes a novel generalized Taylor expansion method of moments (TEMOM) scheme for solving the population balance equation. The proposed scheme can completely overcome the shortcoming of the existing TEMOM and substantially improve the accuracy for both integer and fractional moments. In the generalized TEMOM, the optimal number of equations is 2+1, where is an integer greater than zero. The existing TEMOM is a special case of the generalized TEMOM when is 1. The generalized TEMOM was tested for aerosols undergoing Brownian coagulation in the continuum regime, and it was verified to achieve nearly the same accuracy as the quadrature method of moments (QMOM) with a fractional moment sequence, and higher accuracy than the QMOM with an integer moment sequence. Regarding accuracy and efficiency, the generalized TEMOM scheme was verified to be a competitive method for solving the population balance equation.Copyright 2015 American Association for Aerosol Research
Ag(I) and Zn(II) isonicotinate complexes: Design, characterization, antimicrobial effect and CT–DNA binding studies
Creators: name: M. Almáši
name: Z. Vargová
name: D. Sabolová
name: J. Kudláčová
name: D. Hudecová
name: J. Kuchár
name: L. Očenášová
name: K. Györyová
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Medicine
Engineering
Biochemistry
Biophysics

description: Trinuclear Ag(I) (1) and dinuclear and mononuclear Zn(II) isonicotinate (2 and 3) complexes were prepared and characterized by X–ray crystallography, elemental analysis, IR spectroscopy and thermal analysis. Single crystal analysis of the Ag(I) complex reveals two different monodentate carboxylate coordination modes, protonated and deprotonated, respectively. IR spectra showed correlations between isonicotinate coordination modes and Δ(νas–νs)IR values. In addition, the hydrogen bonds significantly influence a position of carboxylate absorption bands. Moreover, IC50 and MIC data for bacteria, yeasts and filamentous fungi were determined and the binding of Ag(I) and Zn(II) complexes to calf thymus DNA was investigated using electronic absorption, fluorescence and CD measurements. Biological tests showed that the Ag(I) complex is more active than commercially used Ag(I) sulfadiazine against E. Coli. The fluorescence spectral results indicate that the complexes can bind to DNA through an intercalative mode. The Stern–Volmer quenching constants for investigated complexes obtained from the linear quenching plot are in the range of 1.67 × 104 to 3.42 × 104 M–1.
Limited Extension after Linked Total Elbow Arthroplasty in Patients with Rheumatoid Arthritis
Creators: name: Ogino, Hiroko
name: Hiromu Ito
name: Moritoshi Furu
name: Ishikawa, Masahiro
name: Yoshitomi, Hiroyuki
name: Matsuda, Shuichi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Astronomy, Astrophysics, Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Physiology
subject: Medicine
subject: Engineering

description: Objective. Total elbow arthroplasty (TEA) has become an established procedure to relieve pain and to increase the range of motion of the destructed elbow in patients with rheumatoid arthritis (RA). However, some patients still have limited extension after TEA, and the causes of limited extension after TEA have yet to be elucidated.Methods. To examine whether widening of the joint space can cause such limited extension, we retrospectively analyzed 55 cases of linked TEA in patients with RA. There were 7 male and 40 female with a mean age of 63.8 years (range, 30–80 years) and a mean follow-up of 7.5 ± 4.2 years (range, 2.5–15.6 years). The Mayo Elbow Performance Score (MEPS) and radiological measurements were recorded. Widening of the joint space was calculated by subtracting the length measured on postoperative radiograph from preoperative radiograph.Results. MEPS and range of motion were significantly improved after surgery except for extension. The degree of extension was significantly correlated with radiological widening of the joint space in the limited extension group. Correlation analyses showed that postoperative limited extension was correlated with lower MEPS daily function.Conclusions. Limited extension after linked TEA is partly derived from perioperative widening of the joint space and potentially limits daily function in patients with RA.
Characteristics and landcover of estuarine boundaries: implications for the delineation of the South African estuarine functional zone
Creators: name: DA Veldkornet
name: JB Adams
name: L Van Niekerk
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences

description: This study investigated whether the current lateral boundary for estuaries in South Africa, i.e. the estuarine functional zone (EFZ), includes all estuarine habitats. The EFZ covers 173 930 ha in 304 estuaries/outlets nationally. Field surveys and analysis of available aerial images showed that 82 (12 956.70 ha) of these estuaries (26%) had estuarine habitats occurring outside of this boundary. As a result of mapping scale, the National Vegetation Map does not represent habitats that are associated with small estuaries (approximately 50% of South Africa's estuaries). For estuaries in the Western and Eastern Cape provinces, most habitats have been lost due to urban development, whereas in subtropical areas (northern Eastern Cape and KwaZulu-Natal), cultivation has removed estuarine habitat. Although delineation of boundaries can be complicated by landcover changes, the estuarine lateral boundary in Cape estuaries could be identified based on sediment characteristics (moisture content, organic content, electrical conductivity), groundwater characteristics (salinity, conductivity and depth) and plant species. The delineation of the EFZ needs to be consistent, inclusive of all estuarine physical and biological processes, and cost-effective to identify so that it can protect estuarine habitats.
IN03193 Viyaulpata Pillar Inscription
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03193
Epigraphia Zeylanica
Viyaulpata

description: IN03193 Viyaulpata Pillar Inscription - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 21. Viyaulpata Pillar-Inscription,’ Epigraphia Zeylanica 4, pp. 176–180.
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation
Creators: name: Rein, Idun Dale
name: Landsverk, Kirsti Solberg
name: Micci, Francesca
name: Patzke, Sebastian
name: Stokke, Trond
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: PARP inhibitors have been approved for treatment of tumors with mutations in or loss of BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in synthetic lethality are not well understood and varying clinical responses have been observed. We have investigated the dose- and time-dependency of cell growth, cell death and cell cycle traverse of four malignant lymphocyte cell lines treated with the PARP inhibitor Olaparib. PARP inhibition induced a severe growth inhibition in this cell line panel and increased the levels of phosphorylated H2AX-associated DNA damage in S phase. Repair of the remaining replication related damage caused a G2 phase delay before entry into mitosis. The G2 delay, and the growth inhibition, was more pronounced in the absence of functional ATM. Further, Olaparib treated Reh and Granta-519 cells died by apoptosis, while U698 and JVM-2 cells proceeded through mitosis with aberrant chromosomes, skipped cytokinesis, and eventually died by necrosis. The TP53-deficient U698 cells went through several rounds of DNA replication and mitosis without cytokinesis, ending up as multinucleated cells with DNA contents of up to 16n before dying. In summary, we report here for the first time cell cycle-resolved DNA damage induction, and cell line-dependent differences in the mode of cell death caused by PARP inhibition.
Presentation of the Spanish National Chapter at the CoARA National Chapters Exchange Forum 2024
Creators: name: Corbalan, Senena
Publisher: name: Zenodo
Year: 2024

description: Slides presented at the CoARA National Chapters Exchange Forum 2024.  A description of the event is available here: https://coara.eu/news/building-a-stronger-network-coara-national-chapters-convene-for-a-first-exchange-forum/.
Removal of Pb2+, Ni2+ and Cd2+ ions in aqueous media using functionalized MWCNT wrapped polypyrrole nanocomposite
Creators: name: Kanthapazham, Rajakumar
name: Chandramohan Ayyavu
name: Dharmendirakumar Mahendiradas
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry

description: Functionalized multi-walled carbon nanotubes, a wrapped polypyrrole (PPy/o-MWCNT) nanocomposite, were prepared by in situ chemical oxidative polymerization. Characterization of the PPy/o-MWCNT nanocomposite was carried out using attenuated total reflectance infrared spectroscopy, Raman analysis, diffuse reflective ultraviolet–visible spectroscopy, powder X-ray diffraction, thermogravimetric analysis, scanning electron microscopy (SEM), energy dispersive analysis of X-rays (EDAX), transmission electron microscope (TEM) and selective area electron diffraction pattern (SAED). The obtained results confirmed successful synthesis of PPy/o-MWCNT nanocomposite. TEM provided the information about the wrapped tubular carbon nanotubes present in the polymer matrix and SAED pattern additionally confirms the crystalline pattern of the metal-loaded adsorbent. SEM images showed the o-MWCNT even dispersion of polymer matrix beyond the magnification of 200–500. EDAX data revealed the loading of metal ions onto polymer surface which was confirmed due to the presence of corresponding. The PPy/o-MWCNT nanocomposite was used as an efficient adsorbent for the removal of Pb2+, Ni2+and Cd2+ions in aqueous media. Batch experiments show maximum adsorption capacity of PPy/o-MWCNT nanocomposite on Pb2+(408 mg/g), Ni2+(409 mg/g) and Cd2+(392 mg/g). The heavy metal ions adsorption on PPy/o-MWCNT nanocomposite shows fast process and the kinetics followed a pseudo-second-order rate equation (R2 ≈ 0.99).
Analysis of diterpenoid compounds from the latex of two Euphorbiaceae by liquid chromatography‒electrospray ionisation mass spectrometry
Creators: name: A.M. Sobottka
name: C. Görick
name: M.F. Melzig
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Marine Biology
subject: Plant Biology

description: The latex of Euphorbia papillosa A.St.-Hil. and Sapium glandulosum (L.) Morong was phytochemically investigated by liquid chromatography/mass spectrometry. The results reveal the presence of tigliane-type diterpenoid compounds, particularly 12-deoxyphorbol esters, in both species. In addition, ingenane-type diterpene esters were found in the latex of E. papillosa. The latex of S. glandulosum showed only tigliane-type diterpenes, confirming the literature data on this genus. According to mass data, we are proposing the presence of 10 compounds derived from 12-deoxyphorbol monoesters and diesters, from one 12-deoxyphorbaldehyde, from two ingenol derivatives and from one nitrogen-containing phorbol ester in the latex of the analysed species. Considering that 12-deoxy tigliane diterpenes are described as antitumour and antiviral agents, these results indicate a pharmacological potential for these two Euphorbiaceae species.
Knowing digital bodies: exploring digital health subjectivities through online collaboration
Creators: name: Bailey, John
Publisher: name: No Publisher Supplied
Year: 2024

description: This dissertation explores the linked questions: how does digital communication in online communities influence our understanding of health, and how does the notion of the healthy body affect how we communicate in digital communities? In order to conduct this exploration, I draw upon three distinct cases. I first explore the users of body tracking devices, and their beliefs about the privacy of the data they generate while using them. I next investigate a group of citizen scientists who go online to generate informal knowledge around using hallucinogenic mushrooms to treat cluster headache, a rare and poorly understood pain disorder. Finally, I explore the discourse around neurodiversity and the brain among activist bloggers on Tumblr. These three cases present three distinct, yet overlapping, ways in which digital bodies become objects of discourse, contestation, and optimization. I conclude by drawing inferences for productive avenues for future research within these areas.
Generalized TEMOM Scheme for Solving the Population Balance Equation
Creators: name: Mingzhou Yu
name: Yueyan Liu
name: Jianzhong Lin
name: Seipenbusch, Martin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biophysics
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Physiology
subject: Microbiology

description: This paper proposes a novel generalized Taylor expansion method of moments (TEMOM) scheme for solving the population balance equation. The proposed scheme can completely overcome the shortcoming of the existing TEMOM(Yu et al., Aerosol Sci. Technol.42 (2008) 705–713) and substantially improve the accuracy for both integer and fractional moments. In the generalized TEMOM, the optimal number of equations is 2φ+1, where φ is an integer greater than zero. The existing TEMOM is a special case of the generalized TEMOM when φ is 1. The generalized TEMOM was tested for aerosols undergoing Brownian coagulation in the continuum regime, and it was verified to achieve nearly the same accuracy as the quadrature method of moments (QMOM) with a fractional moment sequence, and higher accuracy than the QMOM with an integer moment sequence. Regarding accuracy and efficiency, the generalized TEMOM scheme was verified to be a competitive method for solving the population balance equation.
Adaptation requirements due to anatomical changes in free-breathing and deep-inspiration breath-hold for standard and dose-escalated radiotherapy of lung cancer patients
Creators: name: Sibolt, Patrik
name: Wiviann Ottosson
name: Sjöström, David
name: Larsen, Christina
name: Behrens, Claus F.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Engineering

description: ABSTRACTBackground. Radiotherapy of lung cancer patients is subject to uncertainties related to heterogeneities, anatomical changes and breathing motion. Use of deep-inspiration breath-hold (DIBH) can reduce the treated volume, potentially enabling dose-escalated (DE) treatments. This study was designed to investigate the need for adaptation due to anatomical changes, for both standard (ST) and DE plans in free-breathing (FB) and DIBH.Material and methods. The effect of tumor shrinkage (TS), pleural effusion (PE) and atelectasis was investigated for patients and for a CIRS thorax phantom. Sixteen patients were computed tomography (CT) imaged both in FB and DIBH. Anatomical changes were simulated by CT information editing and re-calculations, of both ST and DE plans, in the treatment planning system. PE was systematically simulated by adding fluid in the dorsal region of the lung and TS by reduction of the tumor volume.Results. Phantom simulations resulted in maximum deviations in mean dose to the GTV-T (GTV-T) of −1% for 3 cm PE and centrally located tumor, and + 3% for TS from 5 cm to 1 cm diameter for an anterior tumor location. For the majority of the patients, simulated PE resulted in a decreasing GTV-T with increasing amount of fluid and increasing GTV-T for decreasing tumor volume. Maximum change in GTV-T of -3% (3 cm PE in FB for both ST and DE plans) and + 10% (2 cm TS in FB for DE plan) was observed. Large atelectasis reduction increased the GTV-T with 2% for FB and had no effect for DIBH.Conclusion. Phantom simulations provided potential adaptation action levels for PE and TS. For the more complex patient geometry, individual assessment of the dosimetric impact is recommended for both ST and DE plans in DIBH as well as in FB. However, DIBH was found to be superior over FB for DE plans, regarding robustness of GTV-T to TS.
18F-FDG and 18F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis
Creators: name: Watanabe, Toshiyuki
name: Takase-Minegishi, Kaoru
name: Ihata, Atsushi
name: Kunishita, Yosuke
name: Kishimoto, Daiga
name: Reikou Kamiyama
name: Maasa Hama
name: Yoshimi, Ryusuke
name: Kirino, Yohei
name: Asami, Yukiko
name: Suda, Akiko
name: Ohno, Shigeru
name: Ukihide Tateishi
name: Ueda, Atsuhisa
name: Takeno, Mitsuhiro
name: Ishigatsubo, Yoshiaki
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective. To compare the findings in rheumatoid arthritis (RA)-affected joints between 18F-fluorodeoxyglucose (FDG) and 18F-fluoride (NaF) positron emission tomography (PET)/computed tomography (CT). Methods. We enrolled twelve RA patients who started a new biologic agent (naïve 9 and switch 3). At entry, both hands were examined by 18F-FDG PET/CT, 18F-NaF PET/CT, and X-ray. Intensity of PET signals was determined by standardized uptake value max (SUVmax) in metacarpophalangeal (MCP), proximal interphalangeal (PIP), and ulnar, medial, and radial regions of the wrists. Hand X-rays were evaluated according to the Genant-modified Sharp score at baseline and 6 months. Results. Both 18F-FDG and 18F-NaF accumulated in RA-affected joints. The SUVmax of 18F-FDG correlated with that of 18F-NaF in individual joints (r = 0.65), though detail distribution was different between two tracers. 18F-NaF and 18F-FDG signals were mainly located in the bone and the surrounding soft tissues, respectively. The sum of SUVmax of 18F-NaF correlated with disease activity score in 28 joint (DAS28), modified health assessment questionnaire (MHAQ), and radiographic progression. 18F-FDG and 18F-NaF signals were associated with the presence of erosions, particularly progressive ones. Conclusion. Our data show that both 18F-FDG and 18F-NaF PET signals were associated with RA-affected joints, especially those with ongoing erosive changes.
Toward Autonomous Driving by Musculoskeletal Humanoids: A Study of Developed Hardware and Learning-Based Software
Creators: name: Kawaharazuka, Kento
name: Tsuzuki, Kei
name: Koga, Yuya
name: Omura, Yusuke
name: Makabe, Tasuku
name: Shinjo, Koki
name: Onitsuka, Moritaka
name: Nagamatsu, Yuya
name: Asano, Yuki
name: Okada, Kei
name: Kawasaki, Koji
name: Inaba, Masayuki
Publisher: name: arXiv
Year: 2024
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: This paper summarizes an autonomous driving project by musculoskeletal humanoids. The musculoskeletal humanoid, which mimics the human body in detail, has redundant sensors and a flexible body structure. These characteristics are suitable for motions with complex environmental contact, and the robot is expected to sit down on the car seat, step on the acceleration and brake pedals, and operate the steering wheel by both arms. We reconsider the developed hardware and software of the musculoskeletal humanoid Musashi in the context of autonomous driving. The respective components of autonomous driving are conducted using the benefits of the hardware and software. Finally, Musashi succeeded in the pedal and steering wheel operations with recognition.
description: Accepted at IEEE Robotics and Automation Magazine
18F-FDG and 18F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis
Creators: name: Watanabe, Toshiyuki
name: Takase-Minegishi, Kaoru
name: Ihata, Atsushi
name: Kunishita, Yosuke
name: Kishimoto, Daiga
name: Reikou Kamiyama
name: Maasa Hama
name: Yoshimi, Ryusuke
name: Kirino, Yohei
name: Asami, Yukiko
name: Suda, Akiko
name: Ohno, Shigeru
name: Ukihide Tateishi
name: Ueda, Atsuhisa
name: Takeno, Mitsuhiro
name: Ishigatsubo, Yoshiaki
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective. To compare the findings in rheumatoid arthritis (RA)-affected joints between 18F-fluorodeoxyglucose (FDG) and 18F-fluoride (NaF) positron emission tomography (PET)/computed tomography (CT). Methods. We enrolled twelve RA patients who started a new biologic agent (naïve 9 and switch 3). At entry, both hands were examined by 18F-FDG PET/CT, 18F-NaF PET/CT, and X-ray. Intensity of PET signals was determined by standardized uptake value max (SUVmax) in metacarpophalangeal (MCP), proximal interphalangeal (PIP), and ulnar, medial, and radial regions of the wrists. Hand X-rays were evaluated according to the Genant-modified Sharp score at baseline and 6 months. Results. Both 18F-FDG and 18F-NaF accumulated in RA-affected joints. The SUVmax of 18F-FDG correlated with that of 18F-NaF in individual joints (r = 0.65), though detail distribution was different between two tracers. 18F-NaF and 18F-FDG signals were mainly located in the bone and the surrounding soft tissues, respectively. The sum of SUVmax of 18F-NaF correlated with disease activity score in 28 joint (DAS28), modified health assessment questionnaire (MHAQ), and radiographic progression. 18F-FDG and 18F-NaF signals were associated with the presence of erosions, particularly progressive ones. Conclusion. Our data show that both 18F-FDG and 18F-NaF PET signals were associated with RA-affected joints, especially those with ongoing erosive changes.