Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)
Creators: name: Specovius, Svenja
name: Zimmermann, Hanna G.
name: Oertel, Frederike Cosima
name: Chien, Claudia
name: Bereuter, Charlotte
name: Cook, Lawrence J.
name: Lana Peixoto, Marco Aurélio
name: Fontenelle, Mariana Andrade
name: Kim, Ho Jin
name: Hyun, Jae-Won
name: Jung, Su-Kyung
name: Palace, Jacqueline
name: Roca-Fernandez, Adriana
name: Diaz, Alejandro Rubio
name: Leite, Maria Isabel
name: Sharma, Srilakshmi M.
name: Ashtari, Fereshte
name: Kafieh, Rahele
name: Dehghani, Alireza
name: Pourazizi, Mohsen
name: Pandit, Lekha
name: Dcunha, Anitha
name: Aktas, Orhan
name: Ringelstein, Marius
name: Albrecht, Philipp
name: May, Eugene
name: Tongco, Caryl
name: Leocani, Letizia
name: Pisa, Marco
name: Radaelli, Marta
name: Martinez-Lapiscina, Elena H.
name: Stiebel-Kalish, Hadas
name: Hellmann, Mark
name: Lotan, Itay
name: Siritho, Sasitorn
name: De Seze, Jérôme
name: Senger, Thomas
name: Havla, Joachim
name: Marignier, Romain
name: Tilikete, Caroline
name: Cobo Calvo, Alvaro
name: Bichuetti, Denis Bernardi
name: Tavares, Ivan Maynart
name: Asgari, Nasrin
name: Soelberg, Kerstin
name: Altintas, Ayse
name: Yildirim, Rengin
name: Tanriverdi, Uygur
name: Jacob, Anu
name: Huda, Saif
name: Rimler, Zoe
name: Reid, Allyson
name: Mao-Draayer, Yang
name: De Castillo, Ibis Soto
name: Yeaman, Michael R.
name: Smith, Terry J.
name: Brandt, Alexander U.
name: Paul, Friedemann
name: GJCF International Clinical Consortium For NMOSD
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: neuro-ophthalmology
subject: neurology
subject: medical retina
subject: radiology
subject: imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. Participants The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. Findings to date The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. Future plans We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.