cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Third-generation chemotherapy agents in the treatment of advanced non-small cell lung cancer: A meta-analysis [2]
Creators: name: Socinski, Mark A.
name: Baggstrom, Maria Q.
name: Fried, Daniel B.
name: Poole, Charles
name: Hensing, Thomas A.
name: Stinchcombe, Thomas E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: No Abstract.
SOPHIE velocimetry of Kepler transit candidates. XIX. The transiting temperate giant planet KOI-3680b
Creators: name: Hebrard, G.
name: Bonomo, A. S.
name: Diaz, R. F.
name: Santerne, A.
name: Santos, N. C.
name: Almenara, J. -M.
name: Barros, S. C. C.
name: Boisse, I.
name: Bouchy, F.
name: Bruno, G.
name: Courcol, B.
name: Deleuil, M.
name: Demangeon, O.
name: Guillot, T.
name: Montagnier, G.
name: Moutou, C.
name: Rey, J.
name: Wilson, P. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Whereas thousands of transiting giant exoplanets are known today, only a few are well characterized with long orbital periods. Here we present KOI-3680b, a new planet in this category. First identified by the Kepler team as a promising candidate from the photometry of the Kepler spacecraft, we establish here its planetary nature from the radial velocity follow-up secured over two years with the SOPHIE spectrograph at Observatoire de Haute-Provence, France. The combined analysis of the whole dataset allows us to fully characterize this new planetary system. KOI-3680b has an orbital period of 141.2417 +/- 0.0001 days, a mass of 1.93 +/- 0.20 M_Jup, and a radius of 0.99 +/- 0.07 R_Jup. It exhibits a highly eccentric orbit (e = 0.50 +/- 0.03) around an early G dwarf. KOI-3680b is the transiting giant planet with the longest period characterized so far around a single star; it offers opportunities to extend studies which were mainly devoted to exoplanets close to their host stars, and to compare both exoplanet populations.
description: 10 pages, 9 figures, 4 tables, accepted for publication in A&A
Farmers’ cooperatives in Southwest China: Beyond the dichotomies of failure/success and (in) authenticity?
Creators: name: Wang, Ju-Han Zoe
name: He, Jun
name: Wilmsen, Brooke
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 300208
subject: Farm management, rural management and agribusiness
classificationCode: 30
subject: Agricultural, veterinary and food sciences

description: China has provided strong policy support for Farmers’ Cooperatives (FCs) in a bid to achieve its agricultural ambitions; however, scholars are divided on their contribution. Based upon three in-depth case studies, we interrogate the simple dichotomies used to describe FCs in China – authentic/inauthentic and failed/successful – arguing that FCs can have beneficial implications for smallholder livelihoods regardless of their organisation, operation and viability. Our research finds that local leadership and smallholder-led initiatives are more important than the authenticity and success of local FCs. We therefore call for a more nuanced understanding of the value of FCs and propose that resources should be diverted to other smallholder-led avenues to sustain China's rural development.
Phanaeus palaeno subsp. excisicornis Balthasar 1939
Creators: name: Bezděk, Aleš
name: Hájek, Jiří
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Phanaeus
Phanaeus palaeno
Phanaeus palaeno excisicornis balthasar, 1939

description: Phanaeus palaeno excisicornis Balthasar, 1939
 Phanaeus palaeno ssp. exisicornis [sic!] Balthasar, 1939b: 247.
The holotype is deposited in NMPC (ex coll. V. Balthasar):
HOLOTYPE (J): ‘Mato Grosso / Zobrys [p] // Typus [p, red label, black frame] // ssp. excisi- / cornis m. [hw] / Dr. V. Balthasar det. [p] // H. Blut determ. [p] / Phanaeus / pretiosus [hw] // Mus. Nat. Pragae / Inv. [p], 26356 [hw, orange label] // ssp.excisicornis m. [hw, green label, black frame] // TYPUS [p, red label, black frame] // Phanaeus [p] / palaeno / n.syn. [hw] / P. Arnaud det. 83 [p]’.
 Current status. Junior subjective synonym of Phanaeus (Notiophanaeus) palaeno Blanchard, 1843, see ARNAUD (1982), EDMONDS (1994) and EDMONDS & ZÍDEK (2012).
 Remark. Original spelling ‘ exisicornis ’ should be corrected to ‘ excisicornis ’ in accordance with Article 32.5.1. of ICZN (1999). It is evident from the original description, that the taxon is characterized mainly by excised transverse carina on its head. Moreover, the spelling ‘ excisicornis ’ was used by Balthasar himself on the identification label.
description: Published as part of Bezděk, Aleš & Hájek, Jiří, 2013, Catalogue of type specimens of beetles (Coleoptera) deposited in the National Museum, Prague, Czech Republic, pp. 387-442 in Acta Entomologica Musei Nationalis Pragae 53 (1) on page 432, DOI: 10.5281/zenodo.5739743
Phase II Trial of Weekly Dose-Dense Paclitaxel in Extensive-Stage Small Cell Lung Cancer: Cancer and Leukemia Group B Study 39901
Creators: name: Socinski, Mark A.
name: Wang, Xiaofei
name: Watson, Dorothy
name: Graziano, Stephen L.
name: Herndon, James E.
name: Green, Mark R.
name: Vokes, Everett
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: INTRODUCTION: Paclitaxel is an active agent in extensive-stage (ES) small cell lung cancer (SCLC). Nevertheless, the optimal schedule is uncertain. A dose-dense schedule was previously evaluated in a Cancer and Leukemia Group B study of patients with non-SCLC, resulting in a 42% response rate and median survival of 12.3 months. Because of these promising results, this dose and schedule of paclitaxel was evaluated in patients with ES-SCLC.

METHODS: Patients were eligible for this phase II trial (Cancer and Leukemia Group B 39901) if they had documented ES-SCLC, no prior chemotherapy, and performance status of 0 to 2. Paclitaxel was administered as an intravenous infusion at 150 mg/m2 over 3 hours weekly for 6 consecutive weeks every 8 weeks.

RESULTS: Thirty-six patients with median age of 65 were enrolled. Of them 25 were men and 33 with a performance status 0 to 1. A median of two 8-week cycles were delivered. The percent of patients with grade 3/4 toxicity included neutropenia 22%, anemia 9%, febrile neutropenia 6%, fatigue 20%, sensory neuropathy 26%, motor neuropathy 11%, and dyspnea 17%. There were two treatment-related deaths, both from pneumonitis. The overall response rate was 33% (3% complete response and 30% partial response). Median progression-free and overall survivals were 3.7 and 9.2 months, respectively. One-year progression-free and overall survivals were 17% and 36%, respectively.

CONCLUSIONS: For patients with ES-SCLC, dose-dense weekly paclitaxel was associated with fairly mild hematologic toxicity. Nevertheless, nonhematologic toxicities, including neuropathy, fatigue, and dyspnea required frequent dose delays and reductions. The overall response rate is disappointing and much lower than that seen with standard platinum-based combinations. Paclitaxel in this dose and schedule should not be used as front-line therapy for patients with ES-SCLC.
Additional file 5: of Myc-like transcriptional factors in wheat: structural and functional organization of the subfamily I members
Creators: name: Strygina, Ksenia
name: Khlestkina, Elena
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The results of bisulfite sequencing in genotypes of near isogenic lines, differ in allelic state of TaMyc-A1: lines S29 and i:S29Pp-A1Pp-D1Pp3P. First and second exons are marketed with yellow and green colour, respectively. Blue â unmethylated CpG sites, red â start-codon (ATG site). (DOCX 13 kb)
Non-Universal Power Law of the "Hall Scattering Rate" in a Single-Layer Cuprate Bi_{2}Sr_{2-x}La_{x}CuO_{6}
Creators: name: Ando, Yoichi
name: Murayama, T.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In-plane resistivity ρ_{ab}, Hall coefficient, and magnetoresistance (MR) are measured in a series of high-quality Bi_{2}Sr_{2-x}La_{x}CuO_{6} crystals with various carrier concentrations, from underdope to overdope. Our crystals show the highest T_c (33 K) and the smallest residual resistivity ever reported for Bi-2201 at optimum doping. It is found that the temperature dependence of the Hall angle obeys a power law T^n with n systematically decreasing with increasing doping, which questions the universality of the Fermi-liquid-like T^2 dependence of the "Hall scattering rate". In particular, the Hall angle of the optimally-doped sample changes as T^{1.7}, not as T^2, while ρ_{ab} shows a good T-linear behavior. The systematics of the MR indicates an increasing role of spin scattering in underdoped samples.
description: 4 pages, 5 figures
Normal-state magnetotransport in La_{1.905}Ba_{0.095}CuO_{4} single crystals
Creators: name: Abe, Yasushi
name: Ando, Yoichi
name: Takeya, J.
name: Tanabe, H.
name: Watauchi, T.
name: Tanaka, I.
name: Kojima, H.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The normal-state magnetotransport properties of La_{2-x}Ba_{x}CuO_{4} single crystals with x=0.095 are measured; at this composition, a structural transition to a low-temperature-tetragonal (LTT) phase occurs without suppression of superconductivity. None of the measured properties (in-plane and out-of-plane resistivity, magnetoresistance, and Hall coefficient) shows any sudden change at the LTT phase transition, indicating that the occurrence of the LTT phase does not necessarily cause an immediate change in the electronic state such as the charge-stripe stabilization.
description: 4 pages, 5 figures
Reminiscence of a magnetization plateau in a magnetization processes of toy-model triangular and tetrahedral clusters
Creators: name: Glazkov, V. N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We discuss magnetization curves of a toy-model trigonal and tetrahedral clusters. Nonlinearity of magnetization with local minimum of differential susceptibility resembling known magnetization plateaus of triangular-lattice and pyrochlore lattice antiferromagnets is observed at intermediate temperature range $ J\lesssim T\lesssimΘ$ (here $J$ is the exchange coupling constant and $Θ$ is a Curie-Weiss temperature). This behavior is due to increased statistical weight of the states with intermediate total spin of the cluster, which is related to the `order-by-disorder' mechanism of plateau stabilization of a macroscopic frustrated magnet.
description: 10 pages, 8 figures
Additional file 5 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
Creators: name: Xu, Pengfei
name: Tao, Chunrong
name: Zhu, Yuyou
name: Wang, Guoping
name: Kong, Lingqi
name: Li, Wenyu
name: Li, Rui
name: Li, Juanji
name: Zhang, Chao
name: Wang, Li
name: Liu, Xinfeng
name: Sun, Wen
name: Hu, Wei
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5: Fig. S5. OZ pre-treatment inhibited p-TAK1 and TAK1 expression in vitro. Primary neurons were incubated with OxyHb (25 μM) to mimic SAH condition in vitro. To inhibit TAK1, neurons were pre-treated with OZ (600 nM) for 2h before OxyHb incubation. (A) Immunoblots and (B) densitometry analysis of p-TAK1 and TAK1 in Control, OxyHb and OxyHb+OZ groups. Data are expressed as mean ± SD, n = 5 in each group. ***P < 0.001 vs Control group; ##P < 0.01, ###P < 0.001 vs OxyHb group.
Non-local conservation in the coupling field: effect on critical dynamics
Creators: name: Sen, Parongama
Publisher: name: arXiv
Year: 1998
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We consider the critical dynamics of a system with an $n$-component non-conserved order parameter coupled to a conserved field with long range diffusion. An exponent $σ$ characterizes the long range transport, $σ=2$ being the known locally conserved case. With renormalisation group calculations done upto one loop order, several regions are found with different values of the dynamic exponent $z$ in the $σ-n$ plane. For $n<4$, there are three regimes, I: nonuniversal, $σ$ dependent $z$, II: universal with $z$ depending on $n$ and III': conservation law irrelevant, $z$ being equal to that in the nonconserved case. The known locally conserved case belongs to regions I and II.
description: 4 pages, revtex, 1 eps figure included, to appear in Journal of Physics A
Phase III Trial Comparing Paclitaxel Poliglumex (CT-2103, PPX) in Combination with Carboplatin Versus Standard Paclitaxel and Carboplatin in the Treatment of PS 2 Patients with Chemotherapy-Naïve Advanced Non-small Cell Lung Cancer
Creators: name: Heigener, David
name: Smakal, Martin
name: Ross, Helen J.
name: Sandalic, Larissa
name: Leśniewski-Kmak, Krzysztof
name: Socinski, Mark A.
name: Oldham, Fred B.
name: Langer, Corey J.
name: Orlov, Sergey V.
name: Eisenfeld, Amy J.
name: Dediu, Mircea
name: Ciuleanu, Tudor E.
name: O’Byrne, Kenneth J.
name: Singer, Jack W.
name: Mikhailov, Sergei M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: INTRODUCTION: Performance status (PS) 2 patients with non-small cell lung cancer (NSCLC) experience more toxicity, lower response rates, and shorter survival times than healthier patients treated with standard chemotherapy. Paclitaxel poliglumex (PPX), a macromolecule drug conjugate of paclitaxel and polyglutamic acid, reduces systemic exposure to peak concentrations of free paclitaxel and may lead to increased concentrations in tumors due to enhanced vascular permeability.

METHODS: Chemotherapy-naive PS 2 patients with advanced NSCLC were randomized to receive carboplatin (area under the curve = 6) and either PPX (210 mg/m/10 min without routine steroid premedication) or paclitaxel (225 mg/m/3 h with standard premedication) every 3 weeks. The primary end point was overall survival.

RESULTS: A total of 400 patients were enrolled. Alopecia, arthralgias/myalgias, and cardiac events were significantly less frequent with PPX/carboplatin, whereas grade > or =3 neutropenia and grade 3 neuropathy showed a trend of worsening. There was no significant difference in the incidence of hypersensitivity reactions despite the absence of routine premedication in the PPX arm. Overall survival was similar between treatment arms (hazard ratio, 0.97; log rank p = 0.769). Median and 1-year survival rates were 7.9 months and 31%, for PPX versus 8 months and 31% for paclitaxel. Disease control rates were 64% and 69% for PPX and paclitaxel, respectively. Time to progression was similar: 3.9 months for PPX/carboplatin versus 4.6 months for paclitaxel/carboplatin (p = 0.210).

CONCLUSION: PPX/carboplatin failed to provide superior survival compared with paclitaxel/carboplatin in the first-line treatment of PS 2 patients with NSCLC, but the results with respect to progression-free survival and overall survival were comparable and the PPX regimen was more convenient.
Additional file 4: of Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
Creators: name: Ozge Yildiz
name: Downes, Gerald
name: Sagerstrรถm, Charles
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Characterization of the prdm12bsa9887 mutant. a. Schematic showing genomic sequence of prdm12b. Exons are indicated as boxes and black lines represent introns. The PR domain and three zinc fingers (ZnF) are highlighted in dark red and blue, respectively. The black arrow indicates a single base pair change in the second intron of prdm12bsa9887. b, c. Sequence traces confirming the expected single nucleotide change in wildtype (b) versus prdm12b+/sa9887 (c) animals. d-g. eng1b expression in 24hpf embryos from a cross of prdm12b+/sa9887 animals. Embryos are shown in dorsal (d, e) or lateral (f, g) view with anterior to the left. eng1b expression is lost in 27% of embryos compared to 73% of embryos showing wildtype eng1b staining. (PDF 1962 kb)
Bayesian negative binomial regression model with unobserved covariates for predicting the frequency of north atlantic tropical storms
Creators: name: Li, Xun
name: Ghosh, Joyee
name: Villarini, Gabriele
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology

description: Predicting the annual frequency of tropical storms is of interest because it can provide basic information towards improved preparation against these storms. Sea surface temperatures (SSTs) averaged over the hurricane season can predict annual tropical cyclone activity well. But predictions need to be made before the hurricane season when the predictors are not yet observed. Several climate models issue forecasts of the SSTs, which can be used instead. Such models use the forecasts of SSTs as surrogates for the true SSTs. We develop a Bayesian negative binomial regression model, which makes a distinction between the true SSTs and their forecasts, both of which are included in the model. For prediction, the true SSTs may be regarded as unobserved predictors and sampled from their posterior predictive distribution. We also have a small fraction of missing data for the SST forecasts from the climate models. Thus, we propose a model that can simultaneously handle missing predictors and variable selection uncertainty. If the main goal is prediction, an interesting question is should we include predictors in the model that are missing at the time of prediction? We attempt to answer this question and demonstrate that our model can provide gains in prediction.
Randomized Phase III Trial Comparing Single-Agent Paclitaxel Poliglumex (CT-2103, PPX) with Single-Agent Gemcitabine or Vinorelbine for the Treatment of PS 2 Patients with Chemotherapy-Naïve Advanced Non-small Cell Lung Cancer
Creators: name: Ganul, Valentin L.
name: Singer, Jack W.
name: Oldham, Fred B.
name: Bondarenko, Igor N.
name: Hotko, Yevhen S.
name: Popovich, Alexander Y.
name: Kostinsky, Ippolit Y.
name: Tomova, Antoaneta
name: Eisenfeld, Amy J.
name: Sandler, Alan B.
name: Bandstra, Bruce
name: Socinski, Mark A.
name: Sandalic, Larissa
name: O'Brien, Mary E.R.
name: Bilynsky˘ı, Borys T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: BACKGROUND: Patients with advanced non-small cell lung cancer (NSCLC) and impaired performance status (PS >or= 2) have limited life expectancies and decreased tolerance for drug-induced toxicities. Current treatment guidelines indicate that PS 2 patients benefit from systemic therapy. Further refinement of treatment in these patients requires reduction of treatment-associated toxicities while maintaining or improving efficacy. Paclitaxel poliglumex (PPX), a macromolecular polymer-drug conjugate of paclitaxel and poly-l-glutamic acid, may enhance the therapeutic index of paclitaxel.

METHODS: Chemotherapy-naive PS 2 patients with advanced NSCLC randomly received single-agent PPX (175 mg/m) or a comparator (single-agent vinorelbine or gemcitabine). The primary end point of this study was overall survival.

RESULTS: Overall survival was similar between treatment arms (hazard ratio [HR] = 0.95; log-rank p = 0.686). Median and 1-year survival were 7.3 months and 26%, respectively, for PPX versus 6.6 months and 26% for the control arm. There was a nonsignificant trend toward improved survival in women in the PPX arm compared with standard single agents (HR = 0.65; p = 0.069). The most frequent grade 3/4 adverse events in the treatment versus control arm were dyspnea (13% versus 17%, respectively) and fatigue (10% versus 9%). Grade 3/4 neutropenia and anemia were reduced in the PPX arm (2% versus 8% and 3% versus 9%, respectively). Neuropathy, a taxane-specific toxicity, was more common in the PPX arm; grade 3 neuropathy was limited to 3%.

CONCLUSIONS: Single-agent PPX, dosed at 175 mg/m, is active and well tolerated in PS 2 patients with advanced NSCLC. Patients on PPX required fewer red blood cell transfusions, hematopoietic growth factors, opioid analgesics, and clinic visits than patients receiving gemcitabine or vinorelbine.
Thermodynamic properties of confined interacting Bose gases - a renormalization group approach
Creators: name: Alber, G.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: A renormalization group method is developed with which thermodynamic properties of a weakly interacting, confined Bose gas can be investigated. Thereby effects originating from a confining potential are taken into account by periodic boundary conditions and by treating the resulting discrete energy levels of the confined degrees of freedom properly. The resulting density of states modifies the flow equations of the renormalization group in momentum space. It is shown that as soon as the characteristic length of confinement becomes comparable to the thermal wave length of a weakly interacting and trapped Bose gas its thermodynamic properties are changed significantly. This is exemplified by investigating characteristic bunching properties of the interacting Bose gas which manifest themselves in the second order coherence factor.
Additional file 3: of Myc-like transcriptional factors in wheat: structural and functional organization of the subfamily I members
Creators: name: Strygina, Ksenia
name: Khlestkina, Elena
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Putative cis-acting regulatory elements identified in the Myc promoters. Promoter analysis was performed using New PLACE database. “+” – coding strand, “–” – template strand. (DOCX 27 kb)
Scarabaeus janssensi Balthasar 1940
Creators: name: Bezděk, Aleš
name: Hájek, Jiří
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Scarabaeus
Scarabaeus janssensi

description: Scarabaeus janssensi Balthasar, 1940
 Scarabaeus janssensi Balthasar, 1940: 67.
The holotype is deposited in NMPC (ex coll. V. Balthasar):
HOLOTYPE (unsexed specimen): ‘ Somalia / OBBIA / 1924 [hw] // Stefanini / e / Puccini [hw] // TYPUS [p, red label]
/ janssensi m. [hw, orange label]’.
 Current status. Scarabaeus (Scarabaeus) janssensi Balthasar, 1940, see, e.g., FERREIRA (1972).
description: Published as part of Bezděk, Aleš & Hájek, Jiří, 2013, Catalogue of type specimens of beetles (Coleoptera) deposited in the National Museum, Prague, Czech Republic, pp. 387-442 in Acta Entomologica Musei Nationalis Pragae 53 (1) on page 434, DOI: 10.5281/zenodo.5739743
The properties of broad absorption line outflows based on a large sample of quasars
Creators: name: He, Zhicheng
name: Wang, Tinggui
name: Liu, Guilin
name: Wang, Huiyuan
name: Bian, Weihao
name: Tchernyshyov, Kirill
name: Mou, Guobin
name: Xu, Youhua
name: Zhou, Hongyan
name: Green, Richard
name: Xu, Jun
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Quasar outflows carry mass, momentum and energy into the surrounding environment, and have long been considered a potential key factor in regulating the growth of supermassive black holes and the evolution of their host galaxies. A crucial parameter for understanding the origin of these outflows and measuring their influence on their host galaxies is the distance (R) between the outflow gas and the galaxy center. While R has been measured in a number of individual galaxies, its distribution remains unknown. Here we report the distributions of R and the kinetic luminosities of quasars outflows, using the statistical properties of broad absorption line variability in a sample of 915 quasars from the Sloan Digital Sky Surveys. The mean and standard deviation of the distribution of R are 10^{1.4+/-0.5} parsecs. The typical outflow distance in this sample is tens of parsec, which is beyond the theoretically predicted location (0.01 ~ 0.1 parsecs) where the accretion disc line-driven wind is launched, but is smaller than the scales of most outflows that are derived using the excited state absorption lines. The typical value of the mass-flow rate is of tens to a hundred solar masses per year, or several times the accretion rate. The typical kinetic-to-bolometric luminosity ratio is a few per cent, indicating that outflows are energetic enough to influence the evolution of their host galaxies.
description: Accepted by Nature Astronomy, 8 pages and 2 figures(main text), 8 supplementary figures
Sisyphus (Sisyphus) natalensis Balthasar 1968
Creators: name: Bezděk, Aleš
name: Hájek, Jiří
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Sisyphus
Sisyphus natalensis

description: Sisyphus (Sisyphus) natalensis Balthasar, 1968
 Sisyphus (s. str.) natalensis Balthasar, 1968: 954.
One paratype is deposited in NMPC (ex coll. V. Balthasar):
PARATYPE (unsexed specimen): ‘Sta. Lucia lake / Potium 18-25.II.1960 [hw] // Natal bor./ leg. Héjja [hw] // Sisyphus
(s. str.) / natalensis / n.sp. Balth. / 68 [hw] Paratypus [p, pink label]’.
 Current status. Valid species.
description: Published as part of Bezděk, Aleš & Hájek, Jiří, 2013, Catalogue of type specimens of beetles (Coleoptera) deposited in the National Museum, Prague, Czech Republic, pp. 387-442 in Acta Entomologica Musei Nationalis Pragae 53 (1) on page 435, DOI: 10.5281/zenodo.5739743
On the nodal structure of nonlinear stationary waves on star graphs
Creators: name: Band, Ram
name: Gnutzmann, Sven
name: Krueger, August J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider stationary waves on nonlinear quantum star graphs, i.e. solutions to the stationary (cubic) nonlinear Schrödinger equation on a metric star graph with Kirchhoff matching conditions at the centre. We prove the existence of solutions that vanish at the centre of the star and classify them according to the nodal structure on each edge (i.e. the number of nodal domains or nodal points that the solution has on each edge). We discuss the relevance of these solutions in more applied settings as starting points for numerical calculations of spectral curves and put our results into the wider context of nodal counting such as the classic Sturm oscillation theorem.
description: 23 pages
Summary Statement Novel Agents in the Treatment of Lung Cancer: Fifth Cambridge Conference Assessing Opportunities for Combination Therapy
Creators: name: Lilenbaum, Rogerio C.
name: Hanke, Jeff
name: Riely, Gregory J.
name: Weitzman, Aaron
name: Blumenschein, George R.
name: Janne, Pasi A.
name: Shapiro, Geoffrey I.
name: Engelman, Jeffrey A.
name: Socinski, Mark
name: Espinoza-Delgado, Igor
name: Sorensen, A Gregory
name: Wakelee, Heather A.
name: Govindan, Ramaswamy
name: Heymach, John V.
name: Shaw, Alice
name: Shepherd, Frances A.
name: Hanna, Nasser H.
name: Lynch, Thomas J.
name: Natale, Ronald B.
name: Sequist, Lecia V.
name: Hirsch, Fred R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The promise of effective targeted therapy for lung cancer requires rigorous identification of potential targets combined with intensive discovery and development efforts aimed at developing effective "drugs" for these targets. We now recognize that getting the right drug to the right target in the right patient is more complicated than one could have imagined a decade ago. As knowledge of targets and development of agents have proliferated and advanced, so too have data demonstrating the biologic heterogeneity of tumors. The finding that lung cancers are genetically diverse and can exhibit several pathways of resistance in response to targeted agents makes the prospect for curative therapy more daunting. It is becoming increasingly clear that single-agent treatment will be the exception rather than the rule. This information raises important new questions about the development and assessment of novel agents in lung cancer treatment: (1) How do we identify the most important drug targets for tumor initiation and maintenance? (2) What is the best way to assess drug candidates that may only be relevant in a small fraction of patients? (3) What models do we use to predict clinical response and identify effective combinations? And (4) how do we bring combination regimens to the clinic, particularly when the agents are not yet approved individually and may be under development from different companies? The Fifth Cambridge Conference on Novel Agents in the Treatment of Lung Cancer was held in Cambridge, Massachusetts, on October 1-2, 2007, to discuss these questions by reviewing recent progress in the field and advancing recommendations for research and patient care. New information, conclusions, and recommendations considered significant for the field by the program faculty are summarized here and presented at greater length in the individual articles and accompanying discussions that comprise the full conference proceedings. A CME activity based on this summary is also available at www.informedicalcme.com/cme.
Bose-Glass behaviour in Bi_{2}Sr_{2}Ca_{1-x}Y_{x}Cu_{2}O_{8} crystals with columnar defects: experimental evidence for variable-range hopping
Creators: name: Soret, J. C.
name: Ammor, L.
name: Phuoc, V. Ta
name: De Sousa, R.
name: Ruyter, A.
name: Wahl, A.
name: Villard, G.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We report on vortex transport in Bi_{2}Sr_{2}Ca_{1-x}Y_{x}Cu_{2}O_{8} crystals irradiated at different doses of heavy ions. We show evidence of a flux-creep resistivity typical of a variable-range vortex hopping mechanism as predicted by Nelson and Vinokur.
description: 5 pages LaTeX2e (uses elsart.cls), 1 Encapsulated PostScript figure
A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl
Creators: name: Wang, Pei
name: Chen, Xin
name: Cai, Cai-Hong
name: Kong, Fan-Dong
name: Huang, Sheng-Zhuo
name: Yuan, Jing-Zhe
name: Xu, Xing-Lian
name: Mei, Wen-Li
name: Dai, Hao-Fu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Biochemistry
Space Science
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: A picrotoxane-type sesquiterpene, dendroterpene E (1), together with five benzene derivatives (2–6), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compound 1 was a new picrotoxane-type sesquiterpene with a C-9/C-1/O/C-11 oxetane ring, which was first encountered in this type of compounds. Compounds 1–3 exhibited inhibitory activities against α-glycosidase.
Additional file 2: of Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
Creators: name: Ozge Yildiz
name: Downes, Gerald
name: Sagerström, Charles
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Sequences of primers used to genotype mutant lines. Detailed features of primers used to genotype mutant lines. For bhlhe22, the bhlhe22–1 and bhlhe22–2 primers were used to amplify genomic DNA while the bhlhe22–3 and bhlhe22–4 primers were used to amplify cDNA. (DOCX 13 kb)
Perfil do egresso do programa de pós graduação em Engenharia Biomédica da Universidade de Brasília - Faculdade do Gama
Creators: name: Abreu, Deniz Helena Pereira
name: Garcia, Euler De Vilhena
name: Rosa, Suélia De Siqueira Fleury
name: Gomes, Marília Miranda Forte
Publisher: name: Zenodo
Year: 2019
Subjects: Engenharia biomédica, egresso, pesquisa qualitativa, formação

description: Este artigo tem por objetivo apresentar um panorama do perfil dos egressos do Programa de Pós-Graduação em Engenharia Biomédica - PPGEB, da Universidade de Brasília Campus Gama. O programa tem o propósito de formar docentes, pesquisadores e profissionais de alto nível, desenvolvendo sua capacidade de criação intelectual e sua competência profissional e acadêmica, com vistas à inovação, avanços científicos, tecnológicos e sociais relacionados às aplicações das engenharias, da biologia e das áreas da saúde. Neste artigo está descrita a metodologia utilizada na etapa inicial da coleta de dados que consistiu em pesquisa bibliográfica. Também foram analisados dados do Anuário Estatístico da UnB e dados disponíveis em relatórios da Plataforma Sucupira, referentes ao período de 2010 a 2017. Dentre os resultados quantitativos apurados foi observado que a maioria dos egressos reside no Distrito Federal, se auto declararam de cor branca e possuem formação básica em Engenharia. A relevância do artigo repousa no fato de que a partir do momento que o perfil do egresso é identificado, torna-se possível estabelecer diretrizes e definir ações mais assertivas para o ProgramaEste artigo tem por objetivo apresentar um panorama do perfil dos egressos do Programa de Pós-Graduação em Engenharia Biomédica - PPGEB, da Universidade de Brasília Campus Gama. O programa tem o propósito de formar docentes, pesquisadores e profissionais de alto nível, desenvolvendo sua capacidade de criação intelectual e sua competência profissional e acadêmica, com vistas à inovação, avanços científicos, tecnológicos e sociais relacionados às aplicações das engenharias, da biologia e das áreas da saúde. Neste artigo está descrita a metodologia utilizada na etapa inicial da coleta de dados que consistiu em pesquisa bibliográfica. Também foram analisados dados do Anuário Estatístico da UnB e dados disponíveis em relatórios da Plataforma Sucupira, referentes ao período de 2010 a 2017. Dentre os resultados quantitativos apurados foi observado que a maioria dos egressos reside no Distrito Federal, se auto declararam de cor branca e possuem formação básica em Engenharia. A relevância do artigo repousa no fato de que a partir do momento que o perfil do egresso é identificado, torna-se possível estabelecer diretrizes e definir ações mais assertivas para o Programa.
Symmetric Versus Nonsymmetric Structure of the Phosphorus Vacancy on InP(110)
Creators: name: Ebert, Ph.
name: Urban, K.
name: Aballe, L.
name: Chen, C. H.
name: Horn, K.
name: Schwarz, G.
name: Neugebauer, J.
name: Scheffler, M.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The atomic and electronic structure of positively charged P vacancies on InP(110) surfaces is determined by combining scanning tunneling microscopy, photoelectron spectroscopy, and density-functional theory calculations. The vacancy exhibits a nonsymmetric rebonded atomic configuration with a charge transfer level 0.75+-0.1 eV above the valence band maximum. The scanning tunneling microscopy (STM) images show only a time average of two degenerate geometries, due to a thermal flip motion between the mirror configurations. This leads to an apparently symmetric STM image, although the ground state atomic structure is nonsymmetric.
description: 5 pages including 3 figures. related publications can be found at http://www.fhi-berlin.mpg.de/th/paper.html
The Current Status and Evolving Role of Sunitinib in Non-small Cell Lung Cancer
Creators: name: Socinski, Mark A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: AbstractSunitinib, a small molecule, is a multitargeted receptor kinase inhibitor which targets the vascular endothelial growth factor receptor and platelet-derived growth factor receptor as well as several others. Initially approved for the treatment of renal cell carcinoma as well as imatinib-resistant gastrointestinal stromal tumors, the activity of sunitinib has been explored in several other solid tumors including non-small cell lung cancer (NSCLC). An initial phase II trial in 63 previously treated NSCLC patients using a dose of 50 mg daily 4 of 6 weeks showed a response rate of 11.1% and a stable disease rate of 26.8%. The median time to disease progression and overall survival was 12.0 and 23.4 weeks, respectively. The principal toxicities included fatigue, pain, myalgias, nausea/vomiting, and hypertension. Three hemorrhagic deaths were reported (two pulmonary and one central nervous system). After this trial was completed, a subsequent sequential cohort of 47 previously treated NSCLC patients were treated on a continuous dosing schedule of sunitinib at 37.5 mg daily. A response rate of 2.1% was reported with a stable disease rate of 19.X%. The median time to progression was 12.3 weeks with a median survival time of 38.1 week. Toxicities were, in general, less frequent and similar to those noted in the initial trial. Sunitinib is currently being evaluated in combination with a number of standard regimens commonly used in NSCLC as well as a maintenance drug after first-line platinum-based treatment of advanced NSCLC. Results of these trials are eagerly awaited and will help define the role of sunitinib in the therapeutic approach to NSCLC.
Additional file 3: of Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
Creators: name: Ozge Yildiz
name: Downes, Gerald
name: Sagerstrรถm, Charles
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 60506 Virology

description: Sequence of mutant prdm12b, bhlhe22 and nkx6.1 alleles. The predicted amino acid sequence for each mutant allele was aligned to the corresponding wildtype sequence using Clustal Omega. (PDF 236 kb)
Scarabaeus babori Balthasar 1934
Creators: name: Bezděk, Aleš
name: Hájek, Jiří
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Scarabaeus
Scarabaeus babori

description: Scarabaeus babori Balthasar, 1934
 Scarabaeus babori Balthasar, 1934: 147.
The lectotype and two paralectotypes are deposited in NMPC (ex coll. V. Balthasar):
LECTOTYPE (J): ‘Elbrus Geb. / Persien Rttr. [p] // Typus [p, red label, black frame] // Sc. babori / Typ. m. [hw] / Dr. Balthasar det. [p] // babori J [hw, blue label] // S. babori Balthasar / LECTOTYPE J / des. J. Zídek 2008 [p]’.
PARALECTOTYPE (♀): ‘Elbrus Geb. / Persien Rttr. [p] // Typus [p, red label, black frame] // Sc. babori / Typ. m. [hw] / Dr. Balthasar det. [p] // babori ♀ [hw, blue label] // S. babori Balthasar / PARALECTOTYPE ♀ / det. J. Zídek 2008 [p]’.
PARALECTOTYPE (J): ‘Elbrus Geb. / Persien Rttr. [p] // Typus [p, red label, black frame] // Sc. babori / Typus m. [hw] / Dr. Balthasar det. [p] // transcaspicus [hw, blue label] // S. transcaspicus Stolfa / nec S. babori Balthasar / det. J. Zídek 2008 [p] // Scarabaeus babori / Balthasar, 1934 / Paralectotypus, J / des. A. Bezděk & J. Hájek, 2013 [p, red label]’.
 Current status. Scarabaeus (Scarabaeus) babori Balthasar, 1934, see ZÍDEK & POKORNÝ (2008).
 Remark. BALTHASAR (1934) described this species from an unkown number of specimens of both sexes. ZÍDEK (2008) found two males and one female in NMPC (in coll. Balthasar). He designated lectotype (male) and one paralectotype (female). Because there is no doubt about the authenticity of the second male, we have labeled it as an additional paralectotype.
description: Published as part of Bezděk, Aleš & Hájek, Jiří, 2013, Catalogue of type specimens of beetles (Coleoptera) deposited in the National Museum, Prague, Czech Republic, pp. 387-442 in Acta Entomologica Musei Nationalis Pragae 53 (1) on page 434, DOI: 10.5281/zenodo.5739743
Impact of the ASCO 2007 Presentation of HOG Lun 01-24/USO-023 on the Prescribing Plans of American Medical Oncologists for Patients with Stage IIIB Non-small Cell Lung Cancer
Creators: name: Lemke, Kristine
name: Rafferty, George
name: Green, Mark R.
name: Willey, Joanne
name: Daniels, Laura
name: West, Howard
name: Socinski, Mark A.
name: Iovino, Lou
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: INTRODUCTION: Nonoperative treatment of stage III non-small cell lung cancer has evolved over the past 30 years. The current approach in the Unites States most often includes concurrent chemoradiotherapy.

METHODS: We have used live, case-based research events to document prescribing plans among American medical oncologists for first-line therapy in patients with N3 stage IIIB non-small cell lung cancer. Changes in prescribing plans documented before and after the 2007 American Society of Clinical Oncology (ASCO) presentation of a Hoosier Oncology Group trial testing the role of consolidation docetaxel chemotherapy in this setting are presented.

RESULTS: Data from 2007 show a post-ASCO shift away from plans for docetaxel consolidation, increased use of concurrent chemoradiotherapy alone, and stable to increased plans for concurrent chemoradiation followed by additional cycles of the chemotherapy used during concurrent management (20%). Preliminary data from 2008 confirm the durability of these changes.

CONCLUSIONS: The findings of the Hoosier Oncology Group trial support a transition away from docetaxel consolidation. A trend in this direction among American medical oncologists is clear from our data. However, nearly 20% of oncologists studied in 2008 still plan to use docetaxel consolidation. Furthermore, a majority of those studied after ASCO 2007 continue to report plans to use more than two cycles of chemotherapy as part of their preferred treatment recommendation despite no level I evidence to support this approach.
Lifetimes of impurity states in crossed magnetic and electric fields
Creators: name: Gyger, Sebastien
name: Martin, Philippe A.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We study the quantum dynamics of localized impurity states created by a point interaction for an electron moving in two dimensions under the influence of a perpendicular magnetic field and an in-plane weak electric field. All impurity states are unstable in presence of the electric field. Their lifetimes are computed and shown to grow in a Gaussian way as the electric field tends to zero.
description: 13 pages, no figures, submitted to J. Math. Phys
Bandwidth controlled insulator-metal transition in BaFe$_2$S$_3$: A Mössbauer study under pressure
Creators: name: Materne, Philipp
name: Bi, Wenli
name: Zhao, Jiyong
name: Hu, Michael Yu
name: Amigó, Maria Lourdes
name: Seiro, Silvia
name: Aswartham, Saicharan
name: Büchner, Bernd
name: Alp, Esen Ercan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: BaFe$_2$S$_3$ is a quasi one-dimensional Mott insulator that orders antiferromagnetically below 117(5)\,K. The application of pressure induces a transition to a metallic state, and superconductivity emerges. The evolution of the magnetic behavior on increasing pressure has up to now been either studied indirectly by means of transport measurements, or by using local magnetic probes only in the low pressure region. Here, we investigate the magnetic properties of BaFe$_2$S$_3$ up to 9.9\,GPa by means of synchrotron $^{57}$Fe Mössbauer spectroscopy experiments, providing the first local magnetic phase diagram. The magnetic ordering temperature increases up to 185(5) K at 7.5\,GPa, and is fully suppressed at 9.9\,GPa. The low-temperature magnetic hyperfine field is continuously reduced from 12.9 to 10.3\,T between 1.4 and 9.1\,GPa, followed by a sudden drop to zero at 9.9\,GPa indicating a first-order phase transition. The pressure dependence of the magnetic order in BaFe$_2$S$_3$ can be qualitatively explained by a combination of a bandwidth-controlled insulator-metal transition as well as a pressure enhanced exchange interaction between Fe-atoms and Fe 3\textit{d}-S 3\textit{p} hybridization.
description: 4 pages, 4 figures
Project Lyra: Catching 1I/'Oumuamua - Mission Opportunities After 2024
Creators: name: Hibberd, Adam
name: Hein, Andreas M.
name: Eubanks, T. Marshall
Publisher: name: arXiv
Year: 2019
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: In October 2017, the first interstellar object within our solar system was discovered. Today designated 1I/'Oumuamua, it shows characteristics that have never before been observed in a celestial body. Due to these characteristics, an in-situ investigation of 1I would be of extraordinary scientific value. Previous studies have demonstrated that a mission to 1I/'Oumuamua is feasible using current and near-term technologies however with an anticipated launch date of 2020-2021, this is too soon to be realistic. This paper aims at addressing the question of the feasibility of a mission to 1I/'Oumuamua in 2024 and beyond. Using the OITS trajectory simulation tool, various scenarios are analyzed, including a powered Jupiter flyby and Solar Oberth maneuver, a Jupiter powered flyby, and more complex flyby schemes including a Mars and Venus flyby. With a powered Jupiter flyby and Solar Oberth maneuver, we identify a trajectory to 1I/'Oumuamua with a launch date in 2033, a total velocity increment of 18.2 km/s, and arrival at 1I/'Oumuamua in 2048. With an additional deep space maneuver before the powered Jupiter flyby, a trajectory with a launch date in 2030, a total velocity increment of 15.3 km/s, and an arrival at 1I/'Oumuamua in 2052 were identified. Both launch dates would provide over a decade for spacecraft development, in contrast to the previously identified 2020-2021 launch dates. Furthermore, the distance from the Sun at the Oberth burn is at 5 Solar radii. This results in heat flux values, which are of the same order of magnitude as for the Parker Solar Probe. We conclude that a mission to 1I/'Oumuamua is feasible, using existing and near-term technologies and there is sufficient time for developing such a mission.