cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 4 of Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway
Creators: name: Chen, Zong
name: Ding, Yong
name: Zeng, Ying
name: Zhang, Xue-Ping
name: Chen, Jian-Yan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Additional file 4.
Triple Deficit Hypothesis: A Panel ARDL and Dumitrescu-Hurlin Panel Causality forEast African Countries
Creators: name: Magoti, Edwin
name: Mabula, Salyungu
name: Ngong’ho, Sende B
name: Magoti, Edwin
name: Mabula, Salyungu
name: Ngong’ho, Sende B
Publisher: name: Unknown
Year: 2020
Subjects: subject: Financial Economics
subject: Research Methods/ Statistical Methods
subject: Current account balance
subject: Fiscal balance
subject: Granger Causality
subject: Panel Cointegration
subject: Savings gap
subject: Triple deficit hypothesis

description: This paper aimed at examining the relevance of triple deficit hypothesis for East African countries, specifically assessing the dynamics of savings gap (SG), fiscal balance (FB) and current account balance (CAB). Secondary data from the International Monetary Fund (IMF)for the time period 2004 through 2018 were used. The study adopted Panel ARDL model and Dumitrescu-Hurlin panel granger causality analysis that allows capturing of slope heterogeneity among each member. The study findings revealed both fiscal balance and savings-investment gap to have a positive impact on current account balance for East African countries. However, the short run coefficients were not significant at both 5% and 10% levels of significant, implying that fiscal balance and savings-investment gap have no impact on current account balance in the short run, but the study further found evidence that the current account balance is on average -1.2991 in the short run for East African countries. Additionally, based on the current study, Dumitrescu-Hurlingranger causality results gave reasonable grounds to conclude that triple deficit hypothesis in East African countries does not hold.
The Lyman Continuum escape fraction of faint galaxies at z~3.3 in the CANDELS/GOODS-North, EGS, and COSMOS fields with LBC
Creators: name: Grazian, A.
name: Giallongo, E.
name: Paris, D.
name: Boutsia, K.
name: Dickinson, M.
name: Santini, P.
name: Windhorst, R. A.
name: Jansen, R. A.
name: Cohen, S. H.
name: Ashcraft, T. A.
name: Scarlata, C.
name: Rutkowski, M. J.
name: Vanzella, E.
name: Cusano, F.
name: Cristiani, S.
name: Giavalisco, M.
name: Ferguson, H. C.
name: Koekemoer, A.
name: Grogin, N. A.
name: Castellano, M.
name: Fiore, F.
name: Fontana, A.
name: Marchi, F.
name: Pedichini, F.
name: Pentericci, L.
name: Amorin, R.
name: Barro, G.
name: Bonchi, A.
name: Bongiorno, A.
name: Faber, S. M.
name: Fumana, M.
name: Galametz, A.
name: Guaita, L.
name: Kocevski, D. D.
name: Merlin, E.
name: Nonino, M.
name: O'Connell, R. W.
name: Pilo, S.
name: Ryan, R. E.
name: Sani, E.
name: Speziali, R.
name: Testa, V.
name: Weiner, B.
name: Yan, H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The reionization of the Universe is one of the most important topics of present day astrophysical research. The most plausible candidates for the reionization process are star-forming galaxies, which according to the predictions of the majority of the theoretical and semi-analytical models should dominate the HI ionizing background at z~3. We aim at measuring the Lyman continuum escape fraction, which is one of the key parameters to compute the contribution of star-forming galaxies to the UV background. We have used ultra-deep U-band imaging (U=30.2mag at 1sigma) by LBC/LBT in the CANDELS/GOODS-North field, as well as deep imaging in COSMOS and EGS fields, in order to estimate the Lyman continuum escape fraction of 69 star-forming galaxies with secure spectroscopic redshifts at 3.27L*), while for the faint population (L=0.2L*) the limit to the escape fraction is ~10%. We have computed the contribution of star-forming galaxies to the observed UV background at z~3 and we have found that it is not enough to keep the Universe ionized at these redshifts, unless their escape fraction increases significantly (>10%) at low luminosities (M1500>-19). We compare our results on the Lyman continuum escape fraction of high-z galaxies with recent estimates in the literature and discuss future prospects to shed light on the end of the Dark Ages. In the future, strong gravitational lensing will be fundamental to measure the Lyman continuum escape fraction down to faint magnitudes (M1500~-16) which are inaccessible with the present instrumentation on blank fields.
description: Accepted for publication in A&A, 16 pages, 6 figures
Additional file 5 of Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway
Creators: name: Chen, Zong
name: Ding, Yong
name: Zeng, Ying
name: Zhang, Xue-Ping
name: Chen, Jian-Yan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Additional file 5.
MOESM2 of A 13-year real-life study on efficacy, safety and biological effects of Vespula venom immunotherapy
Creators: name: Albanesi, Marcello
name: Nico, Andrea
name: Sinisi, Alessandro
name: Giliberti, Lucia
name: Rossi, Maria
name: Rossini, Margherita
name: Kourtis, Georgios
name: Rucco, Anna
name: Loconte, Filomena
name: Muolo, Loredana
name: Zurlo, Marco
name: Bona, Danilo
name: Caiaffa, Maria
name: Macchia, Luigi
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 2: Table S2. ALK-AbellĂ˛ VIT protocol.
Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy
Creators: name: Li, Bo
name: Tan, Tingfei
name: Chu, Weiwei
name: Zhang, Ying
name: Ye, Yuanzi
name: Wang, Shanshan
name: Qin, Yan
name: Tang, Jihui
name: Cao, Xi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Breast cancer is one of the most common types of cancer in female patients with high morbidity and mortality. Multi-drug chemotherapy has significant advantages in the treatment of malignant tumors, especially in reducing drug toxicity, increasing drug sensitivity and reducing drug resistance. The objective of this research is to fabricate lipid nanoemulsions (LNs) for the co-delivery of PTX and docosahexaenoic acid (DHA) with folic acid (FA) decorating (PTX/DHA-FA-LNs), and investigate the anti-tumor activity of the PTX/DHA-FA-LNs against breast cancer both in vitro and in vivo. PTX/DHA-FA-LNs showed a steady release of PTX and DHA from the drug delivery system (DDS) without any burst effect. Furthermore, the PTX/DHA-FA-LNs exhibited a dose-dependent cytotoxicity and a higher rate of apoptosis as compared with the other groups in MCF-7 cells. The cellular uptake study revealed that this LNs were more readily uptaken by MCF-7 cells and M2 macrophages in vitro. Additionally, the targeted effect of PTX/DHA-FA-LNs was aided by FA receptor-mediated endocytosis, and its cytotoxicity was proportional to the cellular uptake efficiency. The anti-tumor efficiency results showed that PTX/DHA-FA-LNs significant inhibited tumor volume growth, prolonged survival time, and reduced toxicity when compared with the other groups. These results indicated that DHA increases the sensitivity of tumor cells and tumor-associated macrophages (ATM2) to PTX, and synergistic effects of folate modification in breast cancer treatment, thus PTX/DHA-FA-LNs may be a promising nanocarrier for breast cancer treatment.
The Effect of Commercial Banks’ Agricultural Credit on Agricultural growth in Uganda
Creators: name: Nakazi, Florence
name: Sunday, Nathan
name: Nakazi, Florence
name: Sunday, Nathan
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agricultural Finance
subject: Commercial bank’s credit
subject: agricultural GDP
subject: ARDL bounds test
subject: Uganda

description: Over the past one decade, commercial banks in Uganda have progressively lent credit to agriculture. However, the increasing commercial bank’s agricultural credit disbursements have not translated into commensurate increase in agricultural GDP growth. Upon this backdrop, the study sought to examine the short run and long run impact of the commercial banks’ credit on agricultural sector growth. Using quarterly time series data sourced from bank of Uganda and Uganda bureau of statistics over the sample period of 2008Q3 -2018Q4, the study applied the Autoregressive Distributed Lag (ARDL) approach to examine that the short run and long term relationship between commercial banks’ credit and Uganda’s agricultural GDP performance.In the long run, we find credit to have significant positive impact on agricultural output. Credit to production is found to have a much higher impact on agriculture output compared to credit to processing and marketing.In the short run, we find bank credit not to have an instantaneous impact on agricultural output.The study provides evidence that commercial banks’ agricultural credit contributes significantly to Uganda’s agricultural sector GDP. Specifically, the study provides evidence of the segment of the agriculture value where credit has the highest impact. This paper contributes to providing policy options for improving agricultural GDP performance in Uganda for example de-risking production segment.
Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles
Creators: name: Zou, Hongmi
name: Li, Meng
name: Li, Xing
name: Zheng, Wendi
name: Kuang, Hongyu
name: Wang, Menglei
name: Zhang, Wenli
name: Ran, Haitao
name: Ma, Huafeng
name: Zhou, Xiyuan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide tuftsin (CMT NPs). The dual-mode imaging ability, antitumor effect, and macrophage immunity activation ability of these nanoparticles combined with laser irradiation were studied. The biosafety of CMT NPs was detected. The multifunctional magnetic nanoparticles enhanced photoacoustic (PA) and magnetic resonance (MR) imaging in vivo and in vitro, facilitating diagnosis and efficacy evaluation. The combined effect of CMT NPs and laser irradiation was recorded and verified. Through the accumulation of magnetic field nanoparticles in tumors, the photothermal conversion of nanoparticles under laser irradiation led directly to tumor apoptosis/necrosis, and the release of tuftsin induced macrophage M1-type activation, resulting in antitumor immune effects. Enhanced PA/MR imaging CMT NPs have great potential in dual-mode image-guided laser/immune cotherapy. The nanoparticles have high biosafety and have potential in cancer treatment.
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0233
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: cartulaire
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0233, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0233, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Clustering and preferential concentration of finite-size particles in forced homogeneous-isotropic turbulence
Creators: name: Uhlmann, Markus
name: Chouippe, Agathe
Publisher: name: arXiv
Year: 2016
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We have performed interface-resolved direct numerical simulations of forced homogeneous-isotropic turbulence in a dilute suspension of spherical particles in the Reynolds number range Re-lambda=115-140. The solid-fluid density ratio was set to 1.5, gravity was set to zero, and two particle diameters were investigated corresponding to approximately 5 and 11 Kolmogorov lengths. Note that these particle sizes are clearly outside the range of validity of the point-particle approximation, as has been shown by Homann & Bec (2010). At the present parameter points the global effect of the particles upon the fluid flow is weak. We observe that the dispersed phase exhibits clustering with moderate intensity. The tendency to cluster, which was quantified in terms of the standard deviation of Voronoi cell volumes, decreases with the particle diameter. We have analyzed the relation between particle locations and the location of intense vortical flow structures. The results do not reveal any significant statistical correlation. Contrarily, we have detected a small but statistically significant preferential location of particles with respect to the `sticky points' proposed by Goto & Vassilicos (2008), i.e. points where the fluid acceleration field is acting such as to increase the local particle concentration in one-way coupled point-particle models under Stokes drag. The presently found statistical correlation between the `sticky points' and the particle locations further increases when focusing on regions with high local concentration. Our results suggest that small finite-size particles can be brought together along the expansive directions of the fluid acceleration field, as previously observed only for the simplest model for sub-Kolmogorov particles. We further discuss the effect of density ratio and collective particle motion upon the basic Eulerian and Lagrangian statistics.
description: accepted for publication in J. Fluid Mech
Additional file 1: Figure S1. of Epidemiology of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies and rheumatoid arthritis among 1.5 million patients in Australian general practice: NPS MedicineWise MedicineInsight dataset
Creators: name: González-Chica, David
name: Vanlint, Simon
name: Hoon, Elizabeth
name: Stocks, Nigel
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Venn diagram for the combined frequency of the investigated musculoskeletal diseases and current consultation for chronic pain. Venn diagram for the combined frequency of the investigated musculoskeletal diseases and current consultation for chronic pain. For “prevalence”, the whole period since the first register available in the MedicineInsight dataset (2000-2016) was considered, while “current consultation” considers the period between Oct/2013 and June/2016. Results for adults (18+ years) who attended one of the 329 Australian General Practices participating in the MedicineInsight program (N=1,501,267). (DOC 218 kb)
Additional file 1: of Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice
Creators: name: Zhang, Jin
name: Wang, Yuchao
name: Dong, Xueshuang
name: Liu, Jianghua
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Figure S1. Crocetin did not affect cell viability in both APPsw-transfected cells (A) and control Hela cells (B). Cells were treated with crocetin at the indicated concentrations for 24 h. Cell viability was measured using MTT assay. (C) APP protein levels were not changed in APPsw-transfected cells after the treatment of crocetin (40 μM) for 24 h. Protein levels were analyzed by western blot. Actin was used as a loading control. Figure S2. Crocetin treatment (30 mg/kg/day) decreased Aβ plaques in AD mice. (DOCX 364 kb)
Generalized Uncertainty Principle as a Consequence of the Effective Field Theory
Creators: name: Faizal, Mir
name: Ali, Ahmed Farag
name: Nassar, Ali
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We will demonstrate that the generalized uncertainty principle exists because of the derivative expansion in the effective field theories. This is because, in the framework of the effective field theories, the minimum measurable length scale has to be integrated away to obtain the low energy effective action. We will analyze the deformation of a massive free scalar field theory by the generalized uncertainty principle, and demonstrate that the minimum measurable length scale corresponds to a second more massive scale in the theory, which has been integrated away. We will also analyze CFT operators dual to this deformed scalar field theory, and observe that scaling of the new CFT operators indicates that they are dual to this more massive scale in the theory. We will use holographic renormalization to explicitly calculate the renormalized boundary action with counterterms for this scalar field theory deformed by the generalized uncertainty principle and show that the generalized uncertainty principle contributes to the matter conformal anomaly.
description: 15 pages, no figures, Accepted for Publication in Physics Letters B
Tumor-derived extracellular vesicles for the active targeting and effective treatment of colorectal tumors in vivo
Creators: name: Du Nguyen, Van
name: Kim, Ho Yong
name: Choi, You Hee
name: Park, Jong-Oh
name: Choi, Eunpyo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Colorectal cancer remains one of the main causes of cancer-related deaths worldwide. Although numerous nanomedicine formulations have been developed to tackle the disease, their low selectivity still limits effective therapeutic outcomes. In this study, we isolated extracellular vesicles (EVs) from CT26 colorectal cancer cells and 4T1 murine mammary carcinoma cells, loaded them with the chemotherapeutic agent (doxorubicin, DOX). Then we evaluated the cellular uptake of the extracellular vesicles both in 2D monolayer and 3D tumor spheroid setups using confocal laser scanning microscope and flow cytometry. In vivo tumor homing of the extracellular vesicles was verified on CT26 tumor bearing BALB/c mice using in vivo imaging system. Finally, in vivo therapeutic effects were evaluated and compared using the same animal models treated with five doses of EV formulations. CT26-EV-DOX exhibited excellent biocompatibility, a high drug-loading capacity, controlled drug release behavior, and a high capability for targeting colorectal cancer cells. In particular, we verified that CT26-EV-DOX could preferentially be up taken by their parent cells and could effectively target and penetrate 3D tumor spheroids resembling colorectal tumors in vivo in comparison with their 4T1 derived EV partner. Additionally, treatment of colorectal tumor-bearing BALB/c mice with of CT26-EV-DOX significantly inhibited the growth of the tumors during the treatment course. The developed CT26-EV-DOX nanoparticles may present a novel and effective strategy for the treatment of colorectal cancer.
Gravitational Collapse of Rotating Supermassive Stars including Nuclear Burning Effects
Creators: name: Uchida, Haruki
name: Shibata, Masaru
name: Yoshida, Takashi
name: Sekiguchi, Yuichiro
name: Umeda, Hideyuki
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Supermassive stars (SMSs) of mass $\gtrsim 10^5 M_\odot$ are candidates for seeds of supermassive black holes found in the center of many massive galaxies. We simulate the gravitational collapse of a rigidly rotating SMS core including nuclear burning effects in axisymmetric numerical-relativity simulation. We find that for realistic initial conditions, the nuclear burning does not play an important role. After the collapse, a torus surrounding a rotating black hole is formed and a fraction of the torus material is ejected. We quantitatively study the relation between the properties of these objects and rotation. We find that if a SMS core is sufficiently rapidly rotating, the torus and outflow mass have approximately $6\%$ and $1\%$ of the initial mass, respectively. The typical average velocity and the total kinetic energy of the outflow are $0.2~c$ and $10^{54-56}$ erg where $c$ is the speed of light. Finally, we briefly discuss the possibility for observing the torus and outflow.
description: 20 pages, 22 figures, 3 tables, submitted to PRD
Additional file 6 of Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway
Creators: name: Chen, Zong
name: Ding, Yong
name: Zeng, Ying
name: Zhang, Xue-Ping
name: Chen, Jian-Yan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Additional file 6.
Folate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma
Creators: name: Shen, Wenwen
name: Ge, Shuke
name: Liu, Xiaoyao
name: Yu, Qi
name: Jiang, Xue
name: Wu, Qian
name: Tian, YuChen
name: Gao, Yu
name: Liu, Ying
name: Wu, Chao
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: In this study, we prepared a folic acid-functionalized SMMC-7721 liver cancer cell membrane (CM)-encapsulated paclitaxel nanocrystals system (FCPN) for hepatoma treatment. Transmission electron microscopy (TEM) characterization showed that FCPN was irregular spherical shapes with a particle size larger than 200 nm and a coated thickness of approximately 20 nm. In an in vitro release experiment, FCPN indicated a slowly release effect of paclitaxel (PTX). Cell experiments demonstrated that FCPN was taken up by SMMC-7721 cells and significantly inhibited the proliferation of SMMC-7721 cells, which illustrated that FCPN had good targeting ability compared with PN and CPN. According to the results of in vivo animal experiments, FCPN significantly inhibited tumor growth. Tissue distribution experiments proved that FCPN could accumulate significantly in tumor tissues, which further explained why FCPN had good targeting ability. These results clearly suggested that folate-functionalized homotypic CM bionic nanosystems might represent a very valuable method for liver cancer treatment in the future.
MOESM1 of A 13-year real-life study on efficacy, safety and biological effects of Vespula venom immunotherapy
Creators: name: Albanesi, Marcello
name: Nico, Andrea
name: Sinisi, Alessandro
name: Giliberti, Lucia
name: Rossi, Maria
name: Rossini, Margherita
name: Kourtis, Georgios
name: Rucco, Anna
name: Loconte, Filomena
name: Muolo, Loredana
name: Zurlo, Marco
name: Bona, Danilo
name: Caiaffa, Maria
name: Macchia, Luigi
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1: Table S1. Comparative table of the existing reports on long-term clinical efficacy of VIT.
Morphological properties of slender Ca II H fibrils observed by SUNRISE II
Creators: name: Gafeira, R.
name: Lagg, A.
name: Solanki, Sami K
name: Jafarzadeh, Shahin
name: Van Noort, M.
name: Barthol, P.
name: Rodriguez, J. Blanco
name: Iniesta, J. C. del Toro
name: Gandorfer, A.
name: Gizon, L.
name: Hirzberger, J.
name: Knolker, M.
name: Suarez, D. Orozco
name: Riethmüller, T. L.
name: Schmidt, W.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We use seeing-free high spatial resolution Ca II H data obtained by the SUNRISE observatory to determine properties of slender fibrils in the lower solar chromosphere. In this work we use intensity images taken with the SUFI instrument in the Ca II H line during the second scientific flight of the SUNRISE observatory to identify and track elongated bright structures. After the identification, we analyze theses structures in order to extract their morphological properties. We identify 598 slender Ca II H fibrils (SCFs) with an average width of around 180 km, a length between 500 km and 4000 km, an average lifetime of ~400 s, and an average curvature of 0.002 arcsec^-1. The maximum lifetime of the SCFs within our time series of 57 minutes is ~2000 s. We discuss similarities and differences of the SCFs with other small-scale, chromospheric structures such as spicules of type I and II, or Ca II K fibrils.
description: Accepted for publication in The Astrophysical Journal Supplement Series
Additional file 7 of Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway
Creators: name: Chen, Zong
name: Ding, Yong
name: Zeng, Ying
name: Zhang, Xue-Ping
name: Chen, Jian-Yan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Additional file 7.
Nonlinearity in Data with Gaps: Application to Ecological and Meteorological Datasets
Creators: name: George, Sandip V.
name: Ambika, G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Datagaps are ubiquitous in real world observational data. Quantifying nonlinearity in data having gaps can be challenging. Reported research points out that interpolation can affect nonlinear quantifiers adversely, artificially introducing signatures of nonlinearity where none exist. In this paper we attempt to quantify the effect that datagaps have on the multifractal spectrum ($f(α)$), in the absence of interpolation. We identify tolerable gap ranges, where the measures defining the $f(α)$ curve do not show considerable deviation from the evenly sampled case. We apply this to the multifractal spectra of multiple data-sets with missing data from the SMEAR database. The datasets we consider include ecological datasets from SMEAR I, namely CO$_2$ exchange variation, photosynthetically active radiation levels and soil moisture variation time series, and meteorological datasets from SMEAR II, namely dew point variation and air temperature variation. We could establish multifractality due to deterministic nonlinearity in two of these datasets, even in the presence of gaps.
description: 8 pages, 6 figures, submitted to Pramana, J. Phys
Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation
Creators: name: Abdelmonem, Rehab
name: Al-Samadi, Inas Essam Ibrahim
name: Nashar, Rasha M. El
name: Jasti, Bhaskara R.
name: El-Nabarawi, Mohamed A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Loratadine (LORA), is a topical antihistamine utilized in the treatment of ocular symptoms of COVID-19. The study aimed to develop a Loratadine Nanostructured Lipid Carriers Ocugel (LORA-NLCs Ocugel), enhance its solubility, trans-corneal penetrability, and bioavailability. full-factorial design was established with 24 trials to investigate the impact of several variables upon NLCs properties. LORA-NLCs were fabricated by using hot melt emulsification combined with high-speed stirring and ultrasonication methods. All obtained formulae were assessed in terms of percent of entrapment efficiency (EE%), size of the particle (PS), zeta potential (ZP), as well as in-vitro release. Via using Design Expert® software the optimum formula was selected, characterized using FTIR, Raman spectroscopy, and stability studies. Gel-based of optimized LORA-NLCs was prepared using 4% HPMC k100m which was further evaluated in terms of physicochemical properties, Ex-vivo, and In-vivo studies. The optimized LORA-NLCs, comprising Compritol 888 ATO®, Labrasol®, and Span® 60 showed EE% of 95.78 ± 0.67%, PS of 156.11 ± 0.54 nm, ZP of −40.10 ± 0.55 Mv, and Qh6% of 99.67 ± 1.09%, respectively. Additionally, it illustrated a spherical morphology and compatibility of LORA with other excipients. Consequently, gel-based on optimized LORA-NLCs showed pH (7.11 ± 0.52), drug content (98.62%± 1.31%), viscosity 2736 cp, and Q12% (90.49 ± 1.32%). LORA-NLCs and LORA-NLCs Ocugel exhibited higher ex-vivo trans-corneal penetrability compared with the aqueous drug dispersion. Confocal laser scanning showed valuable penetration of fluoro-labeled optimized formula and LORA-NLCs Ocugel through corneal. The optimized formula was subjected to an ocular irritation test (Draize Test) that showed the absence of any signs of inflammation in rabbits, and histological analysis showed no effect or damage to rabbit eyeballs. Cmax and the AUC0–24 were higher in LORA-NLCs Ocugel compared with pure Lora dispersion-loaded gel The research findings confirmed that NLCs could enhance solubility, trans-corneal penetrability, and the bioavailability of LORA.
Chimera patterns in two-dimensional networks of coupled neurons
Creators: name: Schmidt, Alexander
name: Kasimatis, Theodoros
name: Hizanidis, Johanne
name: Provata, Astero
name: Hövel, Philipp
Publisher: name: arXiv
Year: 2017
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We discuss synchronization patterns in networks of FitzHugh-Nagumo and Leaky Integrate-and-Fire oscillators coupled in a two-dimensional toroidal geometry. Common feature between the two models is the presence of fast and slow dynamics, a typical characteristic of neurons. Earlier studies have demonstrated that both models when coupled nonlocally in one-dimensional ring networks produce chimera states for a large range of parameter values. In this study, we give evidence of a plethora of two-dimensional chimera patterns of various shapes including spots, rings, stripes, and grids, observed in both models, as well as additional patterns found mainly in the FitzHugh-Nagumo system. Both systems exhibit multistability: For the same parameter values, different initial conditions give rise to different dynamical states. Transitions occur between various patterns when the parameters (coupling range, coupling strength, refractory period, and coupling phase) are varied. Many patterns observe in the two models follow similar rules. For example the diameter of the rings grows linearly with the coupling radius.
description: 15 pages, 20 figures
Additional file 1: Figure S1. of Molecularly Imprinted Core-Shell CdSe@SiO2/CDs as a Ratiometric Fluorescent Probe for 4-Nitrophenol Sensing
Creators: name: Mingyue Liu
name: Gao, Zhao
name: Yanjun Yu
name: Rongxin Su
name: Renliang Huang
name: Qi, Wei
name: Zhimin He
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Plant Biology

description: Fluorescence excitation (dashed line) and emission (solid line) spectra of CDs and CdSe QDs, respectively. Figure S2. UV–vis absorption spectrum of 4-NP and fluorescence emission spectrum of CDs. Figure S3. Size distribution of CdSe@SiO2 (a), CdSe@SiO2/CD (b), and CdSe@SiO2/CD/MIP (c). The mean sizes were 46.7 ± 2.5 nm, 53.6 ± 2.7 nm, and 66.4 ± 2.0 nm, respectively. The red lines are Gauss fits. (DOCX 578 kb)
Quantified asymptotic behaviour of Banach space operators and applications to iterative projection methods
Creators: name: Badea, Catalin
name: Seifert, David
Publisher: name: arXiv
Year: 2017
Subjects: subject: Functional Analysis (math.FA)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We present an extension of our earlier work [Ritt operators and convergence in the method of alternating projections, J. Approx. Theory, 205:133-148, 2016] by proving a general asymptotic result for orbits of an operator acting on a reflexive Banach space. This result is obtained under a condition involving the growth of the resolvent, and we also discuss conditions involving the location and the geometry of the numerical range of the operator. We then apply the general results to some classes of iterative projection methods in approximation theory, such as the Douglas-Rachford splitting method and, under suitable geometric conditions either on the ambient Banach space or on the projection operators, the method of alternating projections.
Additional file 1: of Cost-effectiveness of prostate cancer screening: a systematic review of decision-analytical models
Creators: name: Sanghera, Sabina
name: Coast, Joanna
name: Martin, Richard
name: Donovan, Jenny
name: Mohiuddin, Syed
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Search Strategy Methods. Further details on eligibility criteria, search terms, study selection process, data extraction, quality assessment and data synthesis methods. (DOCX 26Â kb)
‘Mito-Bomb’: a novel mitochondria-targeting nanosystem for ferroptosis-boosted sonodynamic antitumor therapy
Creators: name: Wang, Jianxin
name: Zhao, Zhiyu
name: Liu, Yan
name: Cao, Xinyu
name: Li, Fuxin
name: Ran, Haitao
name: Cao, Yang
name: Wu, Changjun
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Mitochondria play an important role in regulating tumor cell death and metabolism so that they can be potential therapeutic targets. Sonodynamic therapy (SDT) represents an attractive antitumor method that induces apoptosis by producing highly toxic reactive oxygen species (ROS). Mitochondria-targeting SDT can cause oxidative damage and improve the efficiency of tumor therapy. However, due to the nonselective distribution of nanosystems and the anti-apoptotic mechanism of cancer cells, the therapeutic effect of SDT is not ideal. Therefore, we proposed a novel mitochondria-targeting nanosystem (‘Mito-Bomb’) for ferroptosis-boosted SDT. Sonosensitizer IR780 and ferroptosis activator RSL-3 were both encapsulated in biocompatible poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles to form ‘Mito-Bomb’ (named IRP NPs). IR780 in this nanosystem was used to mediate mitochondria-targeting SDT. RSL-3 inhibited the activity of GPX4 in the antioxidant system to induce ferroptosis of tumor cells, which could rewire tumor metabolism and make tumor cells extremely sensitive to SDT-induced apoptosis. Notably, we also found that RSL-3 can inhibit hypoxia inducible factor-1α (HIF-1α) and induce ROS production to improve the efficacy of SDT to synergistically antitumor. RSL-3 was applied as a ‘One-Stone-Three-Birds’ agent for cooperatively enhanced SDT against triple-negative breast cancer. This study presented the first example of RSL-3 boosting mitochondria-targeting SDT as a ferroptosis activator. The ‘Mito-Bomb’ biocompatible nanosystem was expected to become an innovative tumor treatment method and clinical transformation.
Growth-Induced Strain in Chemical Vapor Deposited Monolayer MoS2: Experimental and Theoretical Investigation
Creators: name: Kataria, Satender
name: Wagner, Stefan
name: Cusati, Teresa
name: Fortunelli, Alessandro
name: Iannaccone, Giuseppe
name: Pandey, Himadri
name: Fiori, Gianluca
name: Lemme, Max C.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Monolayer molybdenum disulphide (MoS$_2$) is a promising two-dimensional (2D) material for nanoelectronic and optoelectronic applications. The large-area growth of MoS$_2$ has been demonstrated using chemical vapor deposition (CVD) in a wide range of deposition temperatures from 600 °C to 1000 °C. However, a direct comparison of growth parameters and resulting material properties has not been made so far. Here, we present a systematic experimental and theoretical investigation of optical properties of monolayer MoS$_2$ grown at different temperatures. Micro-Raman and photoluminescence (PL) studies reveal observable inhomogeneities in optical properties of the as-grown single crystalline grains of MoS$_2$. Close examination of the Raman and PL features clearly indicate that growth-induced strain is the main source of distinct optical properties. We carry out density functional theory calculations to describe the interaction of growing MoS$_2$ layers with the growth substrate as the origin of strain. Our work explains the variation of band gap energies of CVD-grown monolayer MoS$_2$, extracted using PL spectroscopy, as a function of deposition temperature. The methodology has general applicability to model and predict the influence of growth conditions on strain in 2D materials.
description: 37 pages, 6 figures, 10 figures in supporting information
title: ADCO, Cartulaire des Dominicains de Dijon (1286), Cart. 221 (H 53), 170 folios, f. 0139
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios, f. 0139, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
Secondary data from the HARMONY areas
Creators: name: Charoniti, Eleni
name: van Rooijen, Tariq
Publisher: name: Zenodo
Year: 2020
Subjects: Spatial & Transport Planning Tools
Sustainable Transition
New Mobility Era
demonstration activities
case studies
cross-metropolitan activities

description: Aligned with the main goals of the project, HARMONY WP9 envisages and works towards efficiently organized demonstration activities. In this framework, task 9.1 specifically focuses on setting up the HARMONY case studies and managing cross-metropolitan activities. It covers all preparatory steps, which are necessary to set-up and coordinate the demonstrations, as well as the stakeholders engagement activities, the primary and secondary data collection and the evaluation of the case studies. The current deliverable aims at identifying the secondary data requirements for the HARMONY models, defining their availability as well as potential limitations, which is an essential part of the process in order to ensure consistent data developments and standards. Deliverable 9.2 firstly provides the secondary data template, developed as a guideline for the different areas on the types of data which need to be considered. Following, the four different case study areas, i.e. Rotterdam, Oxfordshire, Turin and Athens, and their urban development plans are shortly described in separate sections, focusing on their secondary data requirements, availability and limitations. Alternative data sources have been suggested when secondary data are not available. Next to these, a summary of the data management plan for the secondary data is presented, consisting of sections on data security, storage of sensitive data, adherence to the General Data Protection Regulation and data access and usage. The deliverable is completed by the sections on conclusions and references. Lastly, an annex is provided showing the secondary data template, including Land Use Model Data Requirements, Transport Demand Model Data Requirements, Transport Supply Model Data Requirements, Calibration Data Requirements and New Mobility Service Data Requirements.
Integral transform methods: a critical review of various kernels
Creators: name: Orlandini, Giuseppina
name: Turro, Francesco
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Some general remarks about integral transform approaches to response functions are made. Their advantage for calculating cross sections at energies in the continuum is stressed. In particular we discuss the class of kernels that allow calculations of the transform by matrix diagonalization. A particular set of such kernels, namely the wavelets, is tested in a model study.
description: 7 pages, 2 figures. Contribution to the 23rd European Conference on Few-Body Problems in Physics Aarhus, Denmark, 8-12 August 2016
Induction for locally compact quantum groups revisited
Creators: name: Kalantar, Mehrdad
name: Kasprzak, Paweł
name: Skalski, Adam
name: Sołtan, Piotr M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: In this paper we revisit the theory of induced representations in the setting of locally compact quantum groups. In the case of induction from open quantum subgroups, we show that constructions of Kustermans and Vaes are equivalent to the classical, and much simpler, construction of Rieffel. We also prove in general setting the continuity of induction in the sense of Vaes with respect to weak containment.
description: 20 pages
A New Paradigm for Turbulent Transport Across a Steep Gradient in Toroidal Plasmas
Creators: name: Xie, H. S.
name: Xiao, Y.
name: Lin, Z.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: First principle gyrokinetic simulation of the edge turbulent transport in toroidal plasmas finds a reverse trend in the turbulent transport coefficients under strong gradients. It is found that there exist both linear and nonlinear critical gradients for the nonmonotonicity of transport characteristics. The discontinuity of transport flux slope around the turning gradient shows features of second order phase transition. Under strong gradient the most unstable modes are in non-ground eigenstates with unconventional mode structures, which significantly reduces the effective correlation length and thus reverse the transport trend. Our results suggest a completely new mechanism for the low to high confinement mode transition without invoking shear flow or zonal flow.
description: 5 pages, 7 figures, accepted by Phys. Rev. Lett