Treatment Assessment Of Pediatric Brain Tumor Patients In Hospital Infantil Albert Sabin Between 2007-2008 (Amended To 2007-2010)
Creators: name: Felix, Francisco
Publisher: name: Zenodo
Year: 2016
Subjects: pediatric brain tumors, high-risk tumors, epidemiology, retrospective study

description: Central nervous system (CNS) tumors are malignancies that, despite its low incidence, have disproportionately large disabling effects. Among the neurological diseases they are second only to the CNS vascular diseases as a cause of death (BLACK &amp; LOEFLER, 1997). 

Primary tumors of the central nervous system are the malignant solid tumors more common in the pediatric age group, accounting for about 15% of cancers in children. They have an annual incidence of approximately 2.5 cases per 100,000 in children under 15,  being an important differential diagnosis in pediatrics. (Lima et al, 2005). CNS neoplasms are the most common cause of cancer mortality in young people. According to a survey made in the USA, CNS tumors account for 30% of deaths in cases of childhood cancer and is the second leading cause of child death, second only to accidents, in the first year of life. (GURNEY et al, 1999)

The purpose of this study was to evaluate the epidemiological profile of patients undergoing treatment for tumors of the central nervous system in the Pediatric Onco-Hematology Department of Hospital Infantil Albert Sabin (HIAS).

A subgroup of patients with expected poor prognosis, composed of inoperable brain tumors of thalamus and brainstem, and malignant gliomas (grade III and IV WHO), seems to have achieved better results than expected. In order to confirm this empirical observation and quantify this result, we will do an epidemiological profile of this subgroup of patients, comparing with data from our service collected in previous years.
description: Project proposal that was submitted to the Institutional Review Board of Hospital Infantil Albert Sabin and approved in 12/16/2008. Number of approval CAAE 26609514.4.0000.5042
description: {"references": ["Black PM, Loeffler JS. Cancer of the nervous system. Editado por Peter McL. Black e Jay S. Loeffler. Blackwell Science, USA, 1997, pp xv.", "GURNEY JG, Smith MA, Bunin GR. CNS AND MISCELLANEOUS INTRACRANIAL AND INTRASPINAL NEOPLASMS. In Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, Bunin GR (eds). Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. NIH Pub. No. 99-4649. Bethesda, MD, 1999.", "KLEIHUES, P.; CAVANEE, W.K. World Health Organization Classification of Tumors. In: Pathology and Genetics of Tumors of the Nervous System International Agency for Research on Cancer Press. Lyon: 2000. p. 208-241.", "LIMA, E.R. et al. Tumores do Sistema Nervoso Central em Oncologia Pedi\u00e1trica: Considera\u00e7\u00f5es Gerais. Textos cient\u00edficos Sociedade Mineira de Pediatria. Dispon\u00edvel em: www.smp.org.br. Acesso em: 30 set. 2005.", "MUNOZ, Villa A. Oncolog\u00eda Pedi\u00e1trica: avances y perspectivas. Rev Esp Pediatr, Madrid: 1999. v. 45, p.245-259.", "RUTKOWSKI, S. et al. Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone. N Engl J M\u00e9d, 2005. v. 352, p. 978-986."]}