cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cognitive status correlates of subclinical action tremor in female carriers of FMR1 premutation
Creators: name: Loesch-Mdzewska, Danuta
name: Atkinson, Anna
name: Hall, Deborah A
name: Tassone, Flora
name: Stimpson, Paige
name: Storey, Elsdon
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 5202
subject: Biological psychology
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 3202
subject: Clinical sciences

description: Background: There is evidence for a significant excess of kinetic upper limb tremor in non-FXTAS female FMR1 premutation carriers. The present study explores the possibility that this tremor is associated with various other features reminiscent of those occurring in syndromic FXTAS. Sample/methods: This study analyzed the data from an Australian cohort of 48 asymptomatic premutation women. We utilized spiral drawings from CRST, representing action tremor; the CRST total tremor; and ICARS- kinetic tremors/cerebellar ataxia scales. Cognitive tests (involving executive functioning) included SDMT, TMT, two subtests of the WAIS-III: MR and Similarities. Spearman Rank correlations assessed the relationships between the above measures, and the Chi-square tested hypothesis about the association between the white matter hyperintensities (wmhs) in the splenium of corpus callosum assessed from MR images and spiral drawings scores. Results: The spiral drawing scores were significantly correlated with all three non-verbal cognitive test scores, and with the CRST scores; the latter correlated with all four cognitive test measures. Similarities (verbal) scores correlated with CRST, ICARS, and with the remaining cognitive scores. Ordered spiral scores’ categories were significantly associated with the degree of splenium involvement. Conclusion: This study showed that, in non-FXTAS premutation female carriers, sub-symptomatic forms of kinetic tremor were associated with a broader motor, and cognitive (especially executive) dysfunction.
Using MLA Commons and Humanities Commons to Tell the Story of Your Work (MLA 2021)
Creators: name: Donlon, Anne
Publisher: name: unknown
Year: 2021
Subjects: subject: Communication

description: This presentation introduces ways to use MLA Commons and Humanities Commons to curate your online presence, increase the impact of your scholarship, and tell the story of your work. It introduces profiles, sites, groups, and the CORE repository, highlighting the ways members can use these networks for collaboration, discussion, and experimentation with new models of scholarly communication. In addition, it highlights some ways to use the Commons during the convention, and suggests a few activities to get started on the Commons.
Additional file 2 of VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation
Creators: name: Xu, Jichuan
name: Quan, Gang
name: Huang, Wei
name: Jiang, Jianxin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2.
The Behavioural,,,,,,,,,,
Creators: name: fjh
name: asdd
Publisher: name: Zenodo
Year: 2025
Subjects: Octylphenol
Clarias batrachus
acute toxicity
median lethal concentration

description: The present study was aimed to evaluate the median lethal concentration (LC50) of octylphenol for 96 hours in the Indian catfish Clarias batrachus and the behavioural patterns during the exposure period. Behavior is considered as an ideal parameter for studying the effect of environmental pollutant as it reflects the physiological status and greatly influences the fitness of the affected species. The eight different concentrations of octylphenol were exposed to the fish to evaluate the LC50 of octylphenol for 96 hours. The result of the study showed that 30mg/L was the LC50 where 50% of the test animals were killed, which was determined by probit analysis test. The fishes in the treated groups were observed unchanged with respect to their body weight, but their movement affected greatly  as they were move slowly to the surface and remained at the bottom in groups, hitting to the side wall of the aquarium and showed inability to maintain normal posture, refusal of feeding ,jerky movement and finally reached in the vicinity of lethargic nature and rolling of the body prior to death were observed. The increase in mucus deposition on their body with an increase in the concentration of octylphenol and decreased opercular movement were also observed. The result of the study concluded that octylphenol caused to changes in the behavioural patterns of the exposed fishes that can be used as a marker in monitoring the issues related to environmental contaminants.
Additional file 1 of VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation
Creators: name: Xu, Jichuan
name: Quan, Gang
name: Huang, Wei
name: Jiang, Jianxin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Fig. S1. A Protein expression of VSIG2 in normal human pancreatic ductal epithelial (HPDE) and five PC cell lines including PANC-1, MIA PaCa-2, AsPC-1, SW 1990 and BxPC-3 were detected by western blotting. GAPDH was used as a loading control. B Transfection efficiency of VSIG2 knockdown in PANC-1 and AsPC-1 cells was clarified via western blotting, when GAPDH was served as a loading control. C Transfection efficiency of VSIG2 overexpression in PANC-1 and AsPC-1 cells was testified by immunoblotting, while GAPDH was performed as a loading control. D The interaction between VSIG2 and LAMTOR2 was testified by endogenic co-immunoprecipitation (Co-IP) in AsPC-1 cells. E The interaction between VSIG2 and mTOR was verified by endogenic Co-IP assay in AsPC-1 cells. F The interaction of VSIG2 with LAMTOR2 and mTOR and its spatial localization in AsPC-1 cells were observed by immunofluorescence. G Overexpression of VSIG2 detected by immunoblotting in AsPC-1 cells had no effect on protein expression of LAMTOR2 and mTOR. GAPDH was utilized as a loading control. H Transwell assays were utilized to testify the ability of migration and invasion about AsPC-1 cells regarding to down-regulation of VSIG2 and simultaneous elevation of LAMTOR2 or supplement of MHY1485.
Using MLA Commons and Humanities Commons to Tell the Story of Your Work (MLA 2021)
Creators: name: Donlon, Anne
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Communication

description: This presentation introduces ways to use MLA Commons and Humanities Commons to curate your online presence, increase the impact of your scholarship, and tell the story of your work. It introduces profiles, sites, groups, and the CORE repository, highlighting the ways members can use these networks for collaboration, discussion, and experimentation with new models of scholarly communication. In addition, it highlights some ways to use the Commons during the convention, and suggests a few activities to get started on the Commons.
Crafting New Materialist Research Frameworks for Collaborative Response
Creators: name: McMullin, Michelle
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Technical writing

description: Complex socio-technical problems such as climate change and the opioid epidemic strain current conceptions of public problem solving. Practitioners, including technical communication researchers, need methods that address immediate needs while supporting sustained community and policy response. Drawing on new materialist theory, technical communication research methods, and participatory research design, I trace the 2015 outbreak of HIV in Scott County, Indiana, and the subsequent passage of syringe exchange legislation, to craft frameworks for collaborative research calibrated to the messiness of wicked problems. My study draws on analysis of publicly available documents related to the outbreak, and interviews with public health practitioners, and community activists in order to identify sensitizing metaphors, and map how different metaphors organize work. Mapping these differences, and the networks they create for policy-making, operational response and research makes visible the embedded work of technical communication. I hope my research will help scholars and practitioners work more closely and communicate more effectively with more interdisciplinary and diverse audiences, contributing to critical scholarship that builds better communities.
Development of an e-Herbarium of Medicinal Plants in Nandurbar District, Maharashtra: Documentation, Conservation, and Digital Repository
Creators: name: Dipak A. Magare
name: Madhukar. B. Patil
Publisher: name: Zenodo
Year: 2025
Subjects: e-Herbarium
medicinal plants
ethnobotany, conservation, digital documentation

description: This study develops an e-Herbarium to document and conserve medicinal plants in Nandurbar District, Maharashtra. Field surveys identified key species, recorded traditional uses, and authenticated taxonomic details. Herbarium specimens were digitized using high-resolution imaging and database integration. The study highlights indigenous ethnobotanical knowledge, conservation challenges, and the need for sustainable plant use. This research underscores the need for digital transformation in plant conservation efforts, bridging the gap between traditional knowledge and modern scientific approaches. The findings advocate for policy recommendations to safeguard medicinal flora and promote sustainable utilization. The study also opens avenues for future research on the integration of artificial intelligence and geospatial tools in digital herbarium development. Through this initiative, the e-Herbarium serves as a valuable resource for botanists, conservationists, and policymakers, ensuring the preservation and accessibility of medicinal plant knowledge for future generations. The e-Herbarium provides a digital platform for researchers and policymakers, ensuring long-term preservation and accessibility of medicinal plant data.
Additional file 3 of VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation
Creators: name: Xu, Jichuan
name: Quan, Gang
name: Huang, Wei
name: Jiang, Jianxin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3.
Supplemental Material, sj-doc-1-rsw-10.1177_10497315211022827 - Effectiveness of School-Based Child Sexual Abuse Prevention Programs in China: A Meta-Analysis
Creators: name: Zhang, Huiping
name: Shi, Rui
name: Li, Yali
name: Wang, Yang
Publisher: name: SAGE Journals
Year: 2021
Subjects: Psychology not elsewhere classified
Social Policy

description: Supplemental Material, sj-doc-1-rsw-10.1177_10497315211022827 for Effectiveness of School-Based Child Sexual Abuse Prevention Programs in China: A Meta-Analysis by Huiping Zhang, Rui Shi, Yali Li and Yang Wang in Research on Social Work Practice
REACTIONS TO RANSOMWARE VARIANTS AMONG INTERNET USERS: MEASURING PAYMENT EVOCATION
Creators: name: Bays, Jason Cameron
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: System and network security
Human information behaviour

description: Ransomware, a form of malicious software, takes users’ files hostage via encryption and demands payment for their return. Since its inception, ransomware has branched into many different variants, some of which threaten users with scare tactics in order to evoke payment. For this study, four variants of ransomware were examined by presenting vignettes via an anonymous online survey. No actual malware was installed on any devices throughout this study. Their emotional responses were captured as well as their level of familiarity with information security. Responses to the survey after the simulated ransomware vignette were recorded to gauge how users would react to a ransomware attack. Data was analyzed to discover which types of ransomware evoked payment as well as if information security knowledge also had an effect on likelihood to pay. This data is intended to be used to develop better prevention methods and messaging, with an emphasis on promoting training on malware avoidance. The study found most individuals did not choose to pay, and this could be attributed to a distrust of the ransomware threat. Self-reported information security behavior appeared to decrease payment evocation, however, peer information security experience and prior exposure to malware appeared to increase payment evocation.
Dupilumab induced ocular surface diseases: an analysis of FAERS database, literature review and disease-gene interaction networks
Creators: name: Chen, Jiaojiao
name: Li, Huixiang
name: Zhang, Huiyuan
name: ShenTu, Qiaoqiao
name: Wang, Shaoxia
name: Wang, Fei
name: Wang, Yinglin
name: Zhao, Quan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Adverse events (AE) in dupilumab induced ocular surface diseases (DIOSD) have raised concerns regarding its safety. The objective of this study was to evaluate DIOSD by employing database analysis and clinical case review, along with mechanism analysis. Database AE data were extracted from FAERS from 2017 Quarter 1 (Q1) to 2023 Q1. Disproportionality analyses were performed to identify the risk signals associated with DIOSD. Case reports/case series reported on DIOSD from March 2017 to June 2023 were collected for a literature review. The mechanisms of DIOSD were investigated through disease-gene interaction network analysis. A total of 85 signals related to DIOSD were detected from FAERS. The most reported adverse event was ‘dry eye’ (n = 3503, ROR 20.32, 95%CI: 19.53-21.14). There were 36 articles, including 201 cases showing the evidence of DIOSD, with an average age of 43 years. 64.18% patients suffered from severe atopic dermatitis and 48.26% were reported with a previous ocular history. The mechanisms study suggested that tumor necrosis factor play an important role in DIOSD. Our findings support that dupilumab use is associated with exacerbation or new-onset OSD. Particular attention should be focused on eye symptoms during the use of dupilumab.
Infectious complications associated with immune and targeted anti-cancer therapies: a retrospective study of the FDA adverse events reporting system (FAERS)
Creators: name: Alsowaida, Yazed S.
name: Alsolami, Ahmed
name: Almangour, Thamer A.
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Immune and targeted anti-cancer therapies are associated with an increased risk of infectious complications. The objectives of the present study were to evaluate the infectious complications associated with immune and targeted anti-cancer drugs. This was a retrospective study for immune and targeted anti-cancer drugs submitted to the FDA Adverse Event Reporting System (FAERS) from 1996 to 20 March 2024. The primary outcome was the rate of infectious disease events, and the secondary outcomes were the incidence of febrile neutropenia (FN), all-cause mortality, and the top 10 infections in each class. Our study included 14 drug classes comprising 44 drugs. The incidence of infectious complications was 14.31% (110,671/773,130). The highest incidence rate was reported with IL-6 inhibitors (30.89%), the highest incidence of FN was reported with Histone deacetylase inhibitors (8.43%), and the highest all-cause mortality was reported with BCR-ABL tyrosine kinase inhibitors (17.17%). Immune and targeted anti-cancer therapies vary in the incidence of infectious complications. Pirtobrutinib, copanlisib, sirolimus, vorinostat, and tocilizumab were associated with high infectious complications (>30%) that warrant emphasis in the clinical guidelines. Thus, clinicians should vigilantly monitor patients undergoing immune and targeted therapies for infectious complications and use antimicrobial prophylaxes when indicated.
Additional file 1 of Gut microbiota profiling in obese children from Southeastern China
Creators: name: Wang, Jingjing
name: Zhuang, Peifeng
name: Lin, Bin
name: Li, Haiqing
name: Zheng, Jinlu
name: Tang, Wenlin
name: Ye, Wenbin
name: Chen, Xiangjian
name: Zheng, Mingping
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 1: Supplementary Figure 1. STAMP analysis of the differernce among the mildly, moderately and severely obese group. (A) Differences between the mildly obese group and moderately obese group were assessed by STAMP anaysis. (B) Differences between the mildly obese group and severely obese group were assessed by STAMP anaysis. (C) Differences between the moderately obese groups and severely obese groups were assessed by STAMP anaysis.
Infectious complications associated with immune and targeted anti-cancer therapies: a retrospective study of the FDA Adverse Events Reporting System (FAERS)
Creators: name: Alsowaida, Yazed S.
name: Alsolami, Ahmed
name: Almangour, Thamer A.
name: Abraham, Ivo
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Immune and targeted anti-cancer therapies are associated with an increased risk of infectious complications. The objectives of the present study were to evaluate the infectious complications associated with immune and targeted anti-cancer drugs. This was a retrospective for immune and targeted anti-cancer drugs submitted to the FDA Adverse Event Reporting System (FAERS) from 1996 to 20 March 2024. The primary outcome was the rate of infectious disease events, and the secondary outcomes were the incidence of febrile neutropenia (FN), all-cause mortality, and the top 10 infections in each class. Our study included 14 drug classes comprising 44 drugs. The incidence of infectious complications was 14.31% (110,671/773,130). The highest incidence rate was reported with IL-6 inhibitors (30.89%), the highest incidence of FN was reported with Histone deacetylase inhibitors (8.43%), and the highest all-cause mortality was reported with BCR-ABL tyrosine kinase inhibitors (17.17%). Immune and targeted anti-cancer therapies vary in the incidence of infectious complications. Pirtobrutinib, copanlisib, sirolimus, vorinostat, and tocilizumab were associated with high infectious complications (>30%) that warrant emphasis in the clinical guidelines. Thus, clinicians should vigilantly monitor patients undergoing immune and targeted therapies for infectious complications and use antimicrobial prophylaxes when indicated.
"Raus In Die Natur": Das Potenzial Der Natur Für Die Arbeit Mit Jugendlichen In Der Soziokulturellen Animation
Creators: name: Landolt, Selina
name: Muff, Eliane
Publisher: name: Zenodo
Year: 2013
Subjects: subject: gnd:4299677-6
subject: gnd:4028863-8

description: Entwicklungsaufgaben sind Herausforderungen, welche jeder Mensch im Laufe seiner Entwicklung bewältigen muss. Jugendliche befinden sich in einer intensiven Phase ihrer physischen, psychischen und auch sozialen Entwicklung. Durch die gesellschaftlichen Veränderungen haben sich die Anforderungen an Jugendliche gewandelt und Neue sind hinzugekommen. Um diesen gesellschaftlichen und entwicklungsbedingten Ansprüchen gerecht zu werden, braucht es Ressourcen und Fähigkeiten, die zum Kompetenzerwerb führen. Die erforderlichen Bewältigungsstrategien von den Entwicklungsaufgaben eignet sich jeder Mensch individuell an. Die offene Jugendarbeit als Arbeitsfeld der Soziokulturellen Animation verfolgt in ihren Kernzielen Kompetenzförderung und das Stärken des Selbstwertgefühls Jugendlicher. Fachpersonen der offenen Jugendarbeit sehen sich unter anderem als Vermittelnde von Ressourcen und bestärken Jugendliche in der Bewältigung ihrer Entwicklungsaufgaben. Die vorliegende Arbeit zielt darauf ab, den Fachpersonen der offenen Jugendarbeit für die Erreichung ihrer Ziele den Handlungsraum Natur aufzuzeigen. Die natürliche Umgebung hat eine positive Wirkung auf die psychische Verfassung, die soziale Zufriedenheit und die körperliche Gesundheit und stellt ein vielfältiges Potenzial dar. Auf Jugendliche kann der Aufenthalt in der Natur stresslindernd oder kreativitätsanregend wirken und es findet eine Gefühlsregulierung statt. Die Autorinnen gehen der Frage nach, welches Potenzial die Natur für den Kompetenzerwerb und die Bewältigung der jugendspezifischen Entwicklungsaufgaben bietet und verbinden diese miteinander. Sie zeigen auf, wie Fachpersonen der offenen Jugendarbeit anhand ihrer Prinzipien den Kompetenzerwerb im natürlichen Handlungsraum fördern und in welcher Form sie dieses Naturpotenzial in ihre Arbeit einfliessen lassen können.
description: + Code Diss LU: hslusa bask 2013 + Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Soziokultur, 2013
Der HUS-Ausbruch 2011 in Deutschland
Creators: name: Krause, Gérard
name: Frank, Christina
name: Gilsdorf, Andreas
name: Mielke, Martin
name: Schaade, Lars
name: Stark, Klaus
name: Burger, Reinhard
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2012
Subjects: subject: Ausbruch
subject: Öffentlicher Gesundheitsdienst
subject: Surveillance
subject: Hämolytisch-urämisches Syndrom
subject: E. coli
subject: Evaluation
subject: Kommunikation
subject: Management
subject: Outbreak
subject: Hemolytic uremic syndrome
subject: Public health service
subject: Communication
subject: 610 Medizin

description: Von Mai bis Juli 2012 ereignete sich in Norddeutschland der weltweit bisher größte Ausbruch von Erkrankungen am hämolytisch-urämischen Syndrom (HUS) mit schweren Folgen für die unmittelbar Betroffenen, das Gesundheitssystem und die Lebensmittelindustrie. Im Folgenden untersuchen wir im Bereich des Infektionsschutzes Aspekte der Ausbrucherkennung, des Ausbruchmanagements und der Kommunikation anhand wissenschaftlicher Publikationen, von Medienberichten und neuen eigenen Datenauswertungen. Die daraus folgenden 17 Empfehlungen betreffen unter anderem die konsequentere Beteiligung an bzw. Umsetzung bestehender und neuer Surveillancesysteme insbesondere vonseiten der Ärzteschaft, die breite Anwendung von Feintypisierungsdiagnostik, die personelle Verstärkung und effizientere Krisenmanagementstrukturen im öffentlichen Gesundheitsdienst (ÖGD) und die evidenzbasierte Kommunikation seitens der Behörden und wissenschaftlichen Fachgesellschaften. Ausbrüche ähnlicher Dimension können jederzeit wieder auftreten und immense Kosten verursachen, die entsprechende Investitionen in deren Früherkennung und Eindämmung bei Weitem übersteigen. Diese gesellschaftliche Gesamtbilanz sollte trotz knapper Ressourcen im öffentlichen Gesundheitsdienst entsprechend berücksichtigt werden.
description: From May to July 2012 the world’s largest outbreak of hemolytic uremic syndrome (HUS) occurred in northern Germany with dramatic consequences for the population, the health care system and the food industry. In the following we examine the detection of the outbreak, epidemic management and related public communication aspects based on scientific publications, media reports as well as own and new data analyses. The subsequent 17 recommendations concern issues such as participation in and implementation of existing and new surveillance systems particularly with respect to physicians, broad application of finely tuned microbiological typing, improved personnel capacity and crisis management structures within the public health service and evidence-based communication by administrations and scientific associations. Outbreaks of similar dimensions can inevitably occur again and result in costs which will far exceed investments needed for early detection and control. This societal balance should be taken into account in spite of limited resources in the public health sector.
ANALYSIS OF PROCESS INDUCED SHAPE DEFORMATIONS AND RESIDUAL STRESSES IN COMPOSITE PARTS DURING CURE
Creators: name: Patil, Ameya Sanjay
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: Process induced dimensional changes in composite parts has been the topic of interest for many researchers. The residual stresses that are induced in composite laminates during curing process while the laminate is in contact with the process tool often lead to dimensional variations such as spring-in of angles and warpage of flat panels. The traditional trial-and-error approach can work for simple geometries, but composite parts with complex shapes require more sophisticated models. When composite laminates are subjected to thermal stresses, such as the heating and cooling processes during curing, they can become distorted as the in-plane and the throughthicknesscoffcients of thermal expansion are different, as well as chemical shrinkage of the resin, usually cause spring-in. Deformed components can cause problems duringassembly, which signi ficantly increases production costs and affects performance. This thesis focuses on predicting these shape deformations using software simulation of composite manufacturing and curing. Various factors such as resin shrinkage, degrees of cure, difference between through thickness coefficient of thermal expansion of the composite laminate are taken into the consideration. A cure kinetic model is presented which illustrates the matrix behavior during cure. The results obtained using the software then were compared with the experimental values of spring-in from the available literature. The accuracy of ACCS package was validated in this study. Analyzing the effects of various parameters of it was estimated that 3D part simulation is an effective and cost and time saving method to predict fi nal shape of the composite part.
Supplemental material for this article is available online.
Creators: name: Clark, Janine Natalya
name: Jefferies, Philip
name: Foley, Sarah
name: Ungar, Michael
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material for Measuring Resilience in the Context of Conflict-Related Sexual Violence: A Novel Application of the Adult Resilience Measure (ARM) by Janine Natalya Clark, Philip Jefferies, Sarah Foley, and Michael Ungar, in Journal of Interpersonal Violence
Duplicate Books, Facsimiles, and Weeds: A Bibliography with Excerpts, for Scholars and Librarians
Creators: name: Hancher, Michael
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Books
subject: History
subject: Libraries
subject: Material culture

description: Should academic libraries preserve material books or discard them? This wide-ranging bibliography places in historical context the MLA's “Statement on the Significance of Primary Records” (1995).
Evaluating bowel obstruction and ileus events in patients on GLP-1 receptor agonists: a systematic review and meta-analysis
Creators: name: Alfehaid, Lama
name: Alyami, Majed
name: Almohareb, Sumaya
name: Alshaya, Omar
name: Almutairi, Abdulaali
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: This research evaluated the association between glucagon-like peptide-1 receptor agonists (GLP-1 RA) and bowel obstruction or ileus. We searched databases, including Medline, Embase, and Cochrane, for studies on adult patients treated with GLP-1 RA. We included randomized control trials (RCT), cohort, case-control studies, and case reports. We used the Cochrane Risk of Bias tool to evaluate the quality of RCTs and the Newcastle-Ottawa Scale for cohort and case-control studies. Out of 317 records identified, 14 studies were included in the systematic review. The meta-analysis included 6 studies with a combined total of 550,426 participants. The use of GLP-1 RA did not show an incremental risk of bowel obstruction or ileus compared to controls (OR 1.95, 95% CI 0.43–8.79). However, the studies had high heterogeneity (I2 = 94%). A subgroup analysis by specific medication revealed that liraglutide was associated with a significantly high risk of bowel obstruction or ileus (OR 3.0, 95% CI 2.03–4.45; I2 = 0%). GLP-1 receptor agonists do not significantly increase the risk of bowel obstruction or ileus. However, liraglutide is associated with a higher risk compared to semaglutide. Clinicians should remain aware of these rare events while recognizing the benefits of GLP-1 receptor agonists for glycemic control and cardiovascular health. CRD42024585971.
Duplicate Books, Facsimiles, and Weeds: A Bibliography with Excerpts, for Scholars and Librarians
Creators: name: Hancher, Michael
Publisher: name: unknown
Year: 2021
Subjects: subject: Books
subject: Material culture
subject: Libraries
subject: History

description: Should academic libraries preserve material books or discard them? This wide-ranging bibliography places in historical context the MLA's "Statement on the Significance of Primary Records" (1995).
Human Metapneumovirus: Insights from a Ten-Year Molecular and Epidemiological Analysis in Germany
Creators: name: Reiche, Janine
name: Jacobsen, Sonja
name: Neubauer, Katrin
name: Hafemann, Susi
name: Nitsche, Andreas
name: Milde, Jeanette
name: Wolff, Thorsten
name: Schweiger, Brunhilde
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger; Robert Koch-Institut, Biologische Sicherheit
Year: 2014
Subjects: subject: Humans
subject: Female
subject: Male
subject: Adolescent
subject: Adult
subject: Germany/epidemiology
subject: Middle Aged
subject: Young Adult
subject: Phylogeny
subject: Child Preschool
subject: Infant
subject: Child
subject: Genetic Variation
subject: Respiratory Tract Infections/epidemiology
subject: Reverse Transcriptase Polymerase Chain Reaction
subject: Molecular Epidemiology
subject: Metapneumovirus/genetics
subject: Metapneumovirus/isolation & purification
subject: Paramyxoviridae Infections/epidemiology
subject: 610 Medizin

description: Human metapneumovirus (HMPV) is a cause of respiratory tract illness at all ages. In this study the epidemiological and molecular diversity among patients of different ages was investigated. Between 2000–2001 and 2009–2010, HMPV was detected in 3% (138/4,549) of samples from outpatients with influenza-like illness with a new, sensitive real-time RT-PCR assay. Several hundred (797) clinical specimens from hospitalized children below the age of 4 years with acute respiratory illness were investigated and HMPV was detected in 11.9% of them. Investigation of outpatients revealed that HMPV infections occurred in individuals of all ages but were most prevalent in children (0–4 years) and the elderly (>60 years). The most present clinical features of HMPV infections were cough, bronchitis, fever/shivers and pneumonia. About two thirds of HMPV-positive samples were detected in February and March throughout the study period. Molecular characterization of HMPV revealed a complex cyclic pattern of group dominance where HMPV subgroup A and B viruses predominated in general for three consecutive seasons. German HMPV represented all genetic lineages including A1, A2, B1, B2, sub-clusters A2a and A2b. For Germany, not only time-dependent circulation of lineages and sub-clusters was observed but also co-circulation of two or three predominant lineages. Two newly emerging amino acid substitutions (positions 223 and 280) of lineage B2 were detected in seven German HMPV sequences. Our study gives new insights into the molecular epidemiology of HMPV in in- and outpatients over a time period of 10 years for the first time. It is one of only few long-term surveillance studies in Europe, and allows comparative molecular analyses of HMPV circulating worldwide.
Signal detection and analysis of sulfasalazine adverse reaction events based on the US FDA adverse event reporting database
Creators: name: Du, Yikuan
name: Zhang, Lingzhi
name: Shi, Liang
name: Guo, Zhuoming
name: Luo, Ziyi
name: Zheng, Ye
name: Zeng, Yu
name: Huang, Yin
name: Luo, Jiawen
name: Guo, Xiaochun
name: Hu, Mianda
name: Chen, Yuhong
name: Zhu, Jinfeng
name: Liu, Yi
name: Yang, Chun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Based on real data from the FDA Adverse Event Reporting System (FAERS), we explored and evaluated the adverse reactions (ADRs) of sulfasalazine (SSZ) in the first quarter of 2004–2023 to provide a reference basis and early warning for the safe use of SSZ in the clinic. The reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the empirical Bayesian geometric mean (EBGM) were used as measures of SSZ-associated adverse events (AEs) signals, mining for potential positive signals between SSZ and AE. In this study, a total of 5327 case reports related to SSZ in the last 20 years involving 25 system organ classes (SOCs) were collected in FAERS. The AEs of SSZ were mainly focused on Immune system disorders (n = 1621, IC025 = 2.86), Blood and lymphatic system disorders (n = 638, IC025 = 2.4), and others. In addition, we found 41 adverse reactions not mentioned in the specification, including oculomucocutaneous syndrome (n = 12, IC025 = 4.86), wegener’s granulomatosis(n = 6, IC025 = 4.05) and reproductive system aspects. Significant new AEs signals were observed in this study and may provide important support for clinical monitoring and risk identification in SSZ.
Fatal Monkeypox in Wild-Living Sooty Mangabey, Côte d’Ivoire, 2012
Creators: name: Radonić, Aleksandar
name: Metzger, Sonja
name: Dabrowski, Piotr Wojtek
name: Couacy-Hymann, Emmanuel
name: Schünadel, Livia
name: Kurth, Andreas
name: Mätz-Rensing, Kerstin
name: Boesch, Christophe
name: Leendertz, Fabian
name: Nitsche, Andreas
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2014
Subjects: subject: Animals
subject: Phylogeny
subject: Genome Viral
subject: Phylogeography
subject: Animals Newborn
subject: Cercocebus atys/virology
subject: Cote d'Ivoire
subject: Fatal Outcome
subject: High-Throughput Nucleotide Sequencing
subject: Monkeypox/virology
subject: Monkeypox virus/classification
subject: Monkeypox virus/genetics
subject: Monkeypox virus/isolation & purification
subject: 610 Medizin

description: We isolated a monkeypox virus from a wild-living monkey, a sooty mangabey, found dead in Taï National Park, Côte d’Ivoire, in March 2012. The whole-genome sequence obtained from this isolate and directly from clinical specimens showed its close relationship to monkeypox viruses from Western Africa.
Signal detection and analysis of Sulfasalazine adverse reaction events based on the US FDA adverse event reporting database
Creators: name: Du, Yikuan
name: Zhang, Lingzhi
name: Shi, Liang
name: Guo, Zhuoming
name: Luo, Ziyi
name: Zheng, Ye
name: Zeng, Yu
name: Huang, Yin
name: Luo, Jiawen
name: Guo, Xiaochun
name: Hu, Mianda
name: Chen, Yuhong
name: Zhu, Jinfeng
name: Liu, Yi
name: Yang, Chun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Based on real data from the FDA Adverse Event Reporting System (FAERS), we explored and evaluated the adverse reactions (ADRs) of sulfasalazine (SSZ) in the first quarter of 2004-2023 to provide a reference basis and early warning for the safe use of SSZ in the clinic. The reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the empirical Bayesian geometric mean (EBGM) were used as measures of SSZ-associated adverse events (AEs) signals, mining for potential positive signals between SSZ and AE. In this study, a total of 5327 case reports related to SSZ in the last 20 years involving 25 system organ classes (SOCs) were collected in FAERS. The AEs of SSZ were mainly focused on Immune system disorders (n = 1621, IC025 = 2.86), Blood and lymphatic system disorders (n = 638, IC025 = 2.4), and others. Notably, the more severe DRESS syndrome was included in Immune system disorders. In addition, we found 41 adverse reactions not mentioned in the specification, including oculomucocutaneous syndrome(n = 12，IC025 = 4.86), wegener’s granulomatosis(n = 6, IC025 = 4.05) and reproductive system aspects. Significant new AEs signals were observed in this study and may provide important support for clinical monitoring and risk identification in SSZ.
Additional file 1 of Long-term push–pull cropping system shifts soil and maize-root microbiome diversity paving way to resilient farming system
Creators: name: Jalloh, Abdul A.
name: Khamis, Fathiya Mbarak
name: Yusuf, Abdullahi Ahmed
name: Subramanian, Sevgan
name: Mutyambai, Daniel Munyao
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 1.
EVALUATING BOWEL OBSTRUCTION and ILEUS EVENTS in PATIENTS on GLP-1 RECEPTOR AGONISTS: A SYSTEMATIC REVIEW and META-ANALYSIS
Creators: name: Alfehaid, Lama
name: Alyami, Majed
name: Almohareb, Sumaya
name: Alshaya, Omar
name: Almutairi, Abdulaali
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: This research evaluated the association between glucagon-like peptide-1 receptor agonists (GLP-1 RA) and bowel obstruction or ileus. We searched databases, including Medline, Embase, and Cochrane, for studies on adult patients treated with GLP-1 RA. We included randomized control trials (RCT), cohort, case-control studies, and case reports. We used the Cochrane Risk of Bias tool to evaluate the quality of RCTs and the Newcastle-Ottawa Scale for cohort and case-control studies. Out of 317 records identified, 14 studies were included in the systematic review. The meta-analysis included 6 studies with a combined total of 550,426 participants. The use of GLP-1 RA did not show an incremental risk of bowel obstruction or ileus compared to controls (OR 1.95, 95% CI 0.43-8.79). However, the studies had high heterogeneity (I2 = 94%). A subgroup analysis by specific medication revealed that liraglutide was associated with a significantly high risk of bowel obstruction or ileus (OR 3.0, 95% CI 2.03-4.45; I2 = 0%). GLP-1 receptor agonists do not significantly increase the risk of bowel obstruction or ileus. However, liraglutide is associated with a higher risk compared to semaglutide. Clinicians should remain aware of these rare events while recognizing the benefits of GLP-1 receptor agonists for glycemic control and cardiovascular health. CRD42024585971
Tabak- und Alkoholkonsum bei 11- bis 17-jährigen Jugendlichen
Creators: name: Lampert, Thomas
name: Kuntz, Benjamin
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2014
Subjects: subject: Gesundheitssurvey
subject: Jugendliche
subject: Rauchen
subject: Sozioökonomischer Status
subject: Alkoholkonsum
subject: Tabakkonsum
subject: Smoking
subject: Adolescents
subject: Health survey
subject: Alcohol consumption
subject: Socioeconomic status
subject: Tobacco consumption
subject: 610 Medizin

description: Analysiert wird der Tabak- und Alkoholkonsum von Jugendlichen in Deutschland. Neben der aktuellen Situation werden auch zeitliche Entwicklungen und Trends berichtet. Als Datenbasis dient die erste Folgebefragung der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS Welle 1), die in den Jahren 2009 bis 2012 durchgeführt wurde. Einbezogen wurden alle Mädchen und Jungen im Alter von 11 bis 17 Jahren (n = 5258). Die Ergebnisse zeigen, dass aktuell 12,0 % der 11- bis 17-jährigen Jugendlichen in Deutschland rauchen. Darin eingeschlossen sind 5,4 % der Jugendlichen, die täglich rauchen. Ein riskanter Alkoholkonsum (AUDIT-C-Gesamtwert) ist bei 15,8 % der Heranwachsenden festzustellen, regelmäßiges Rauschtrinken (mindestens einmal im Monat 6 oder mehr alkoholische Getränke bei einer Gelegenheit) bei 11,5 %. Zwischen den Geschlechtern sind in Bezug auf die meisten Indikatoren keine signifikanten Unterschiede festzustellen. Lediglich bei den 14- bis 17-Jährigen zeigt sich, dass Jungen häufiger als Mädchen zu regelmäßigem Rauschtrinken neigen (23,1 vs. 16,5 %, p 
description: In this paper, tobacco and alcohol consumption among adolescents in Germany was analyzed. In addition to the current situation, we report temporal developments and trends. Data were obtained from the first follow-up of the KiGGS study (KiGGS Wave 1) conducted from 2009 to 2012. All girls and boys aged 11–17 years (n = 5,258) were included. The results show that currently 12.0 % of 11- to 17-year-old adolescents in Germany smoke, 5.4 % of them on a daily basis. At-risk drinking (AUDIT-C total score) was prevalent among 15.8 % of adolescents, heavy episodic drinking (six or more alcoholic standard drinks on a single occasion at least once a month) among 11.5 %. No significant gender differences were found for most indicators. However, among adolescents aged 14–17 years, boys revealed a greater inclination toward heavy episodic drinking than girls did (23.1 vs. 16.5 %, p
The mglA gene and its flanking regions in Brucella: The role of mglA in tolerance to hostile environments, Fe-metabolism and in vivo persistence
Creators: name: Jacob, Jens
name: Finke, Antje
name: Mielke, Martin
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2012
Subjects: subject: Bacterial/genetics
subject: Animals
subject: Female
subject: Molecular Sequence Data
subject: Mice
subject: Gene Deletion
subject: DNA
subject: Sequence Analysis DNA
subject: Disease Models Animal
subject: Culture Media/chemistry
subject: Mice Inbred BALB C
subject: Virulence
subject: Bacterial Load
subject: Brucella/genetics
subject: Brucella/pathogenicity
subject: Brucella/physiology
subject: Brucellosis/microbiology
subject: Iron/metabolism
subject: Osmotic Pressure
subject: Oxidative Stress
subject: Spleen/microbiology
subject: Stress Physiological
subject: 610 Medizin

description: We previously demonstrated that a spontaneous smooth small-colony variant of Brucella abortus S19 is characterized by increased in vivo persistence and the differential expression of a gene predicted to encode a galactoside transport ATP binding protein (mglA). In order to further investigate the role of this gene in the context of its flanking regions, we analyzed the respective DNA sequences from the formerly described B. abortus S19 as well as from avirulent B. neotomae 5K33 and compared these with published data from other Brucella species. Deletion mutagenesis of mglA in the large-colony variant of B. abortus S19 resulted in increased tolerance of the deletion mutant to a hyperosmotic (toxic), galactose-containing medium as well as to oxidative stress (H2O2). Whilst the deletion mutant is characterized by reduced growth on solid Fe3+-containing minimal medium (small-colony morphology), in vivo studies in mice demonstrated statistical significant differences in the bacterial load of spleens in the pre-immune, but not in the late phase of the infection.
Sexual behavior and factors associated with young age at first intercourse and HPV vaccine uptake among young women in Germany: implications for HPV vaccination policies
Creators: name: Remschmidt, Cornelius
name: Fesenfeld, Michaela
name: Kaufmann, Andreas M.
name: Deleré, Yvonne
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2014
Subjects: subject: Sexually transmitted infections
subject: Sexual behavior
subject: First intercourse
subject: HPV vaccination
subject: 610 Medizin

description: Background: In Germany, immunization against human papillomaviruses (HPV) is free of charge for all females aged 12 to 17 years. Since HPV infection rates rise soon after first intercourse, immunization against HPV should be completed before sexual debut. Knowledge of country-specific data on age at first intercourse and related risk factors is important to optimize prevention of HPV and other sexually transmitted infections. Therefore, the primary aim of this study was to describe sexual behavior in young women in Germany. Secondary aims were to identify factors that are (i) associated with younger age at first intercourse and (ii) with HPV vaccine uptake. Methods: Between 2010 and 2012, we conducted a cross-sectional study among randomly selected women aged 20 to 25 years in Germany. We used a structured, self-administered questionnaire to collect sociodemographic data, information on sexual habits such as age at first intercourse, and information on HPV vaccine uptake. We used univariate and multivariate logistic regression analyses to identify factors associated with younger age at first intercourse and with HPV vaccine uptake. Results: A total of 823 women (response rate: 14.2%) participated, 785 (95.4%) of which reported having had intercourse already. 70% of these women experienced first intercourse before the age of 18 years. However, less than 5% were younger than 14 years at sexual debut. Younger age at first intercourse was independently associated with a higher number of sexual partners, smoking, and past pregnancies. HPV vaccine uptake was associated with higher education, whereas smoking and a migrant background reduced the chance of being vaccinated. Conclusion: In Germany, only a small proportion of women experienced first intercourse before the age of 14 years. Younger age at first intercourse was associated with behavior that might increase the risk of HPV infections or other sexually transmitted infections. Therefore, to optimize the HPV vaccination strategy, HPV vaccination series should be completed before the age of 14 years in Germany.