cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Search for the single production of doubly-charged Higgs bosons at OPAL
Creators: name: Groll, Marius
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2003
Subjects: thesis
electron positron: colliding beams
photon electron: interaction
Higgs particle: search for
Higgs particle: charged particle
charge: 2
Higgs particle: triplet
Higgs particle: photoproduction
Higgs particle: leptonic decay
lepton: pair production
coupling: (Higgs particle 2electron)
channel cross section
upper limit
Higgs particle: exchange
symmetry: left-right
Higgs particle: mass
lower limit
numerical calculations: Monte Carlo
OPAL
experimental results
CERN LEP Stor
bibliography
189-209 GeV-cms

description: Universität Hamburg, Diplomarbeit, 2003; 75 pp., (2003). doi:10.3204/DESY-THESIS-2003-044
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
title: Luftqualität 2019
title: Luftqualität 2019
titleType: AlternativeTitle
Creators: name: Dauert, Ute
name: Feigenspan, Stefan
name: Kessinger, Susan
name: Minkos, Andrea
name: Mues, Andrea C.
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Stickstoffdioxid
subject: Feinstaub
subject: Ozon
subject: Luftgüte
subject: PM10
subject: Luftqualität
subject: NO2
subject: Luft

description: Diese Auswertung der Luftqualität im Jahr 2019 in Deutschland basiert auf vorläufigen, noch nicht abschließend geprüften Daten aus den Luftmessnetzen der Bundesländer und des Umweltbundesamtes, Stand Januar 2020. Aufgrund der umfangreichen Qualitätssicherung in den Messnetzen stehen die endgültigen Daten erst Mitte 2020 zur Verfügung. Die jetzt vorliegenden Daten lassen aber eine generelle Einschätzung des vergangenen Jahres zu. Betrachtet werden die Schadstoffe Feinstaub(PM10und PM2,5 ), Stickstoffdioxid (NO2) sowie Ozon (O3), da bei diesen Überschreitungen geltender Grenz- und Zielwerte/WHO-Empfehlungen zum Schutz der menschlichen Gesundheit auftreten. Quelle: https://www.umweltbundesamt.de
description: Diese Auswertung der Luftqualität im Jahr 2019 in Deutschland basiert auf vorläufigen, noch nicht abschließend geprüften Daten aus den Luftmessnetzen der Bundesländer und des Umweltbundesamtes, Stand Januar 2020. Aufgrund der umfangreichen Qualitätssicherung in den Messnetzen stehen die endgültigen Daten erst Mitte 2020 zur Verfügung. Die jetzt vorliegenden Daten lassen aber eine generelle Einschätzung des vergangenen Jahres zu. Betrachtet werden die Schadstoffe Feinstaub (⁠PM10⁠ und ⁠PM2,5⁠), Stickstoffdioxid (NO2) sowie Ozon (O3), da bei diesen Überschreitungen geltender Grenz- und Zielwerte/⁠WHO⁠-Empfehlungen zum Schutz der menschlichen Gesundheit auftreten.
Hypergraph Learning based Recommender System for Anomaly Detection, Control and Optimization
Creators: name: Srinivas, Sakhinana Sagar
name: Sarkar, Rajat Kumar
name: Runkana, Venkataramana
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Anomaly detection is fundamental yet, challenging problem with practical applications in industry. The current approaches neglect the higher-order dependencies within the networks of interconnected sensors in the high-dimensional time series(multisensor data) for anomaly detection. To this end, we present a self-adapting anomaly detection framework for joint learning of (a) discrete hypergraph structure and (b) modeling the temporal trends and spatial relations among the interdependent sensors using the hierarchical encoder-decoder architecture to overcome the challenges. The hypergraph representation learning-based framework exploits the relational inductive biases in the hypergraph-structured data to learn the pointwise single-step-ahead forecasts through the self-supervised autoregressive task and predicts the anomalies based on the forecast error. Furthermore, our framework incentivizes learning the anomaly-diagnosis ontology through a differentiable approach. It derives the anomaly information propagation-based computational hypergraphs for root cause analysis and provides recommendations through an offline, optimal predictive control policy to remedy an anomaly. We conduct extensive experiments to evaluate the proposed method on the benchmark datasets for fair and rigorous comparison with the popular baselines. The proposed method outperforms the baseline models and achieves SOTA performance. We report the ablation studies to support the efficacy of the framework.
description: 16 pages, 10 figure, Accepted at IEEE International Conference on Big Data 2022, Osaka, Japan
The Epidemiology of Residential Fires Among Children and Youth in Canada
Creators: name: Smith, Jennifer
name: Dhinsa, Arpreet
name: Rajabali, Fahra
name: Zheng, Alex
name: Bruin, Samantha
name: Pike, Ian, 1958-
Publisher: name: The University of British Columbia
Year: 2021

description: The purpose of this report is to detail the epidemiology and burden of residential fire injuries and deaths among Canadian children and youth, aged 0 to 19 years for the ten-year period, 2005-2015. For the first time, comprehensive fire data from across Canada is available in the National Firefighters Information Database. Using this novel dataset, this report explores the impact of residential fires on children and youth in five provinces from 2005 to 2015c. Socioeconomic and geographic vulnerabilities are described within the context of a population and public health framework.
title: Minderung der Stickstoffoxid-Emissionen durch Softwareupdates an Diesel-Pkw
title: Minderung der Stickstoffoxid-Emissionen durch Softwareupdates an Diesel-Pkw
titleType: AlternativeTitle
Creators: name: Lange, Martin
Publisher: name: Umweltbundesamt
Year: 2021

description: In dieser Studie wurden Emissionsfaktoren für betriebswarmen Zustand auf Basis von Emissionsmessungen sowohl im realen Verkehr als auch auf dem Rollenprüfstand (Fahrzyklus WLTC) an Pkw Euro 5 und 6 mit verpflichtenden und freiwilligen Softwareupdates erstellt und die erzielten NOx-Minderungen bestimmt. NOx-Temperaturkorrekturfunktionen und Kaltstartzusatzemissionen konnten aus den WLTC-Messungen ermittelt werden. Die Daten sollen im nächsten Update des Handbuchs für Emissionsfaktoren des Straßenverkehrs (HBEFA) zusätzlich zu den EA 189 Software-Updates der VW-Konzernfahrzeuge einfließen und stehen damit für Emissions- und Immissionsmodellierungen zur Verfügung. Quelle: www.umweltbundesamt.de
The Feasibility, Acceptability, and Efficacy of Delivering Internet-Based Self-Help and Guided Self-Help Interventions for Generalized Anxiety Disorder to Indian University Students: Design of a Randomized Controlled Trial
Creators: name: Kanuri, Nitya
name: Newman, Michelle G
name: Ruzek, Josef I
name: Kuhn, Eric
name: Manjula, M
name: Jones, Megan
name: Thomas, Neil
name: Abbott, Jo-Anne
name: Sharma, Smita
name: Taylor, C. Barr
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 520302
subject: Clinical psychology

description: Generalized anxiety disorder (GAD) is one of the most common mental disorders among university students however, many students go untreated due to treatment costs, stigma concerns, and limited access to trained mental health professionals. These barriers are heightened in universities in India, where there are scant mental health care services and severe stigma surrounding help seeking.
Mutation of the Highly Conserved Ser-40 of the HIV-1 p6 Gag Protein to Phe Causes the Formation of a Hydrophobic Patch, Enhances Membrane Association, and Polyubiquitination of Gag
Creators: name: Hahn, Friedrich
name: Setz, Christian
name: Friedrich, Melanie
name: Rauch, Pia
name: Solbak, Sara Marie
name: Frøystein, Nils Åge
name: Henklein, Petra
name: Votteler, Jörg
name: Fossen, Torgils
name: Schubert, Ulrich
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the cell membrane. It was recently demonstrated that mutation of the highly conserved Ser-40 to Phe (S40F) disturbs CA-SP1 processing, virus morphogenesis, and infectivity. It also causes the formation of filopodia-like structures, while virus release remains unaffected. Here, we show that the mutation S40F, but not the conservative mutation to Asp (S40D) or Asn (S40N), augments membrane association, K48-linked polyubiquitination, entry into the 26S proteasome, and, consequently, enhances MHC-I antigen presentation of Gag derived epitopes. Nuclear magnetic resonance (NMR) structure analyses revealed that the newly introduced Phe-40, together with Tyr-36, causes the formation of a hydrophobic patch at the C-terminal α-helix of p6, providing a molecular rationale for the enhanced membrane association of Gag observed in vitro and in HIV-1 expressing cells. The extended exposure of the S40F mutant to unidentified membrane-resident ubiquitin E3-ligases might trigger the polyubiquitination of Gag. The cumulative data support a previous model of a so far undefined property of p6, which, in addition to MA, acts as membrane targeting domain of Gag.
Supplementary document for Robust countermeasure against detector control attack in practical quantum key distribution system - 3773444.pdf
Creators: name: Qian, yongjun
name: He, De-Yong
name: Wang, Shuang
name: Chen, Wei
name: Yin, Zhen-Qiang
name: Guo, Guang-can
name: Han, Zhen-fu
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Quantum Optics

description: supplemental document
Efficient deep learning based assisted annotation for medical image segmentation
Creators: name: Zhang, Lichun
Publisher: name: University of Iowa
Year: 2023
Subjects: Active Learning
Assisted Annotation
Deep Learning
LOGISMOS
Medical Image Segmentation
Self-Supervised Learning
public abstract

description: Medical image segmentation is widely recognized as one of the most challenging tasks in medical image analysis. It involves identifying the set of voxels that constitute organs or lesions of interest from the background. Accurate segmentation is crucial for conducting quantitative measurements and analysis of clinical parameters such as volume, shape and intensity distribution. Furthermore, it enables physicians to monitor disease status and progression, predict disease course and select the most appropriate treatment plans in clinical practice. To improve segmentation accuracy and reduce the burden on experts, various semi-automated and automated approaches have been proposed. Recently, deep learning methods based on artificial neural networks have revolutionized medical image analysis and achieved state-of-the-art results in many challenges. However, several impediments remain. Firstly, deep learning results may be imperfect on explicit topology and require further improvement. Secondly, accurate annotation of medical image datasets is pivotal in deep learning, but the process is not only tedious and time-consuming but also demands costly, specialty-oriented knowledge and skills that are not easily accessible. Therefore, this dissertation aims to address these critical problems by developing efficient deep learning algorithms for medical image segmentation when annotated datasets are limited/unavailable and effectively assisting human experts to decrease annotation effort. This dissertation outlines three specific aims from different perspectives: (1) Develop novel methods for efficient assisted annotation in the Deep-LOGISMOS-JEI framework to utilize existing annotation effectively for improved segmentation; (2) Develop novel strategies to utilize automatic segmentation quality assessment (SQA) to acquire necessary annotation efficiently to reduce the demand for training data size and assist experts in annotating images effectively; (3) Develop novel self-supervised learning approaches for deriving representations/features from large unannotated medical image datasets to improve segmentation performance on small annotated datasets. The effectiveness of the proposed methods was demonstrated by experiments on calf muscle segmentation on magnetic resonance (MR) images, vessel wall and lumen segmentation on intravascular ultrasound (IVUS) images and psoas muscle segmentation on computed tomography (CT) images.
The influence of social media integration on the donation attractiveness of food charities in the context of food waste in Melbourne
Creators: name: Hassan, Shehryar
Publisher: name: Swinburne
Year: 2024

description: This study explores how social media integration influences the donation attractiveness of food charities in the context of food waste in Melbourne. Given the explorative nature of the study, it employed a qualitative research approach with a comparative case study method. The outcome of study can help food charities compare and share knowledge of the focus of social media strategies to enhance their ability to reach out to food donors. Furthermore, the findings could also inform the policy development effort of the Victorian government toward curbing food waste and to productively utilise the food that could be wasted.
Kinetic and structural implications of using noncanonical amino acids and purification tags to study proteins
Creators: name: Luedtke, Nicholas A.
Publisher: name: University of Iowa
Year: 2025
Subjects: enzyme
fusion purification
protein dynamics
protein labeling
protein modification
Structural Biology

description: Proteins can be chemically modified or mutated to create more efficient workflows and make experiments feasible like in the cases of molecular tethering and purification aids. Inclusion of one or more of these tools renders the desired protein different from the native protein, however this may be negligible if no perturbation is observed during control experiments. That conclusion may only be valid within the scope of the question asked. Here, two case studies examine two popular protein modifications, purification tags and noncanonical amino acids, and use comparative studies against to evaluate the invasiveness of these protein modifications against wild type.
description: Purine nucleoside phosphorylase is used as a model system to understand the structural implications of using para-cyanophenylalanine (CNF) as an active site probe. An extensive investigation to determine a valid, physiologically relevant consensus sequence found WT and G51S variants of PNP are kinetically and structurally similar. From this WT sequence, amber codon suppression is used to express F159CNF and F200CNF single mutants for kinetic and structural analysis. Solubility was found to be problematic for F200CNF, yet it maintained observable activity while the steady state turnover number, kcat , for F159CNF decreased by a factor of two from WT. Structural investigations show F159CNF is remarkably similar to WT and a previously published structure of F159Y with no discernable harm to key active site residue positions whereas F200CNF slightly contorts the O5’of transition state analogue, ImmH, to become planar with O4’ and C4’ which may mask future measurements if CNF is used to spectroscopically probe PNP’s rate promoting vibration.
description: Formate dehydrogenase is used as a model system to systematically assess how hexahistidine tags with and without tobacco etch virus cleavage sites disrupt steady state kinetics and active site structure. The set of expressed variants are kinetically active with only a modest reduction in kcat observed for the variant with a single N-terminal serine. Structural analysis is performed from molecular dynamics simulations of the complete set of tagged FDH peptides to find some variants alter the 3.4 cm-1 and 7.4 cm-1 peaks in the WT spectral density plot which could indicate allosteric communication to the active site. This is further investigated with hydride donor and acceptor distance and angle calculations across each simulation to find some N- and C-terminal variants have shorter probable distances which could artificially inflate hydride tunneling probability in prospective experiments.
title: Synapses as therapeutic targets for autism spectrum disorders
title: an international symposium held in Pavia on July 4th, 2014
titleType: Subtitle
Creators: name: Curatolo, Paolo
name: Ben-Ari, Yehezkel
name: Bozzi, Yuri
name: Catania, Maria Vincenza
name: D’Angelo, Egidio
name: Mapelli, Lisa
name: Oberman, Lindsay M.
name: Rosenmund, Christian
name: Cherubini, Enrico
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: New progresses into the molecular and cellular mechanisms of autism spectrum disorders (ASDs) have been discussed in 1 day international symposium held in Pavia (Italy) on July 4th, 2014 entitled “synapses as therapeutic targets for autism spectrum disorders” (satellite of the FENS Forum for Neuroscience, Milan, 2014). In particular, world experts in the field have highlighted how animal models of ASDs have greatly advanced our understanding of the molecular pathways involved in synaptic dysfunction leading sometimes to “synaptic clinical trials” in children.
Stimulants for ADHD in children : Revisited
Creators: name: Therapeutics Initiative (University Of British Columbia)
Publisher: name: The University of British Columbia
Year: 2023

description: Therapeutics Letter 110 reviews the evidence for stimulants in children with ADHD. Conclusions: Whether the benefits of long-term CNS stimulants for ADHD in children outweigh the harms remains unknown. There is convincing evidence that a proportion of boys and girls treated with stimulants in BC and around the world are simply the youngest in their class. There is insufficient evidence to know whether our publications or research findings had an impact on the overall rate of stimulant drug prescribing in BC children. The recent increase in CNS stimulant prescribing in BC is unexplained and concerning.
Issues in integrating and implementing an open source toolkit and demonstration system for digital image watermarks
Creators: name: Zeng, Qingwen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.
subject: Engineering, System Science.

description: Free/Libre and Open Source Software (FLOSS) has been an important factor in the software world and it has profoundly changed the way people deal with software products. However, it seems that little job appear to have been done to develop digital watermarking systems as FLOSS. Developing such a system requires multiple-disciplinary knowledge of digital image watermarking techniques, digital image processing, information hiding, computer science technology and cryptography. The demands of these diverse subjects may suggest that building such a system is a difficult task. This thesis explores the feasibility of setting up an Internet-based digital image watermarking system capable of embedding and extracting text messages as FLOSS. Several digital watermarking algorithms, such as Least Significant Bit, Patchwork, brightness modulation and DFT amplitude and phase modulations were explored. A choice was made to adopt a J2EE (Java 2 Platform Enterprise Edition) browser/server structure to build the embedding/extraction subsystems and to use Java, HTML/XML and Javascript languages to implement the system, as these are independent of specific computing platforms (eg, Windows or Linux). A trade-off analysis on watermark imperceptibility, robustness, reliability and capacity of algorithms was carried out and taken into consideration in shortening the processing time in the empirical system. The thesis work has developed an illustrative framework for future extension and research.
3809242.pdf
Creators: name: Sun, Ke
name: Gao, Jun
name: Cao, Ming-Ming
name: Jiao, Zhi-Qiang
name: Liu, Yu
name: Li, Zhan-Ming
name: Poem, Eilon
name: Eckstein, Andreas
name: Ren, Ruo-Jing
name: Pang, Xiao-Ling
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Materials
Covariant quantization of N = 1, D = 5 supersymmetric Yang-Mills theories in 4D superfield formalism
Creators: name: Flacke, Thomas
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2003
Subjects: thesis
gauge field theory: Yang-Mills
supersymmetry: superfield
dimension: 5
dimension: 4
dimensional reduction
perturbation theory: higher-order
renormalization group: beta function
propagator

description: Universität Hamburg, Diplomarbeit, 2003; 89 pp., (2003). doi:10.3204/DESY-THESIS-2003-047
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Catenary optics for achromatic generation of perfect optical angular momentum
Creators: name: Pu, Mingbo
name: Li, Xiangping
name: Ma, Xiaoliang
name: Wang, Yanqin
name: Zhao, Zeyu
name: Wang, Changtao
name: Hu, Chenggang
name: Gao, Ping
name: Huang, Cheng
name: Ren, Haoran
name: Qin, Fei
name: Yang, Jing
name: Gu, Min
name: Hong, Minghui
name: Luo, Xiangang
Publisher: name: Swinburne
Year: 2024

description: The catenary is the curve that a free-hanging chain assumes under its own weight, and thought to be a 'true mathematical and mechanical form' in architecture by Robert Hooke in the 1670s, with nevertheless no significant phenomena observed in optics. We show that the optical catenary can serve as a unique building block of metasurfaces to produce continuous and linear phase shift covering [0, 2π], a mission that is extremely difficult if not impossible for state-of-the-art technology. Via catenary arrays, planar optical devices are designed and experimentally characterized to generate various kinds of beams carrying orbital angular momentum (OAM). These devices can operate in an ultra-broadband spectrum because the anisotropic modes associated with the spin-orbit interaction are almost independent of the incident light frequency. By combining the optical and topological characteristics, our approach would allow the complete control of photons within a single nanometric layer.
title: Data-driven exploration in x-ray astronomy
title: investigating intermediate polar candidates found among unusual objects selected by an unsupervised outlier identification algorithm
titleType: Subtitle
Creators: name: Swarm, Dustin K
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: Astronomers are increasingly faced with a deluge of information, and finding worthwhile targets of study in the sea of data can be difficult. Outlier identification studies are a method that can be used to focus investigations by presenting a smaller set of sources that could prove interesting because they do not follow the trends of the underlying population. We apply a principal component analysis (PCA) and an unsu- pervised random forest algorithm (uRF) to sources from the Chandra Source Catalog v.2 (CSC2). We present 119 high-significance sources that appear in all repeated ap- plications of our outlier identification algorithm (OIA). We analyze the characteristics of our outlier sources and crossmatch them with the SIMBAD database. Among the 119 outlier sources are 34 unclassified X-ray point sources located in the Galactic cen- ter (GC). Previous population studies of thousands of GC X-ray point sources suggest that the majority of the observed X-ray flux originates from class of magnetic cata- clysmic variable (CV) known as an intermediate polar (IP). We conduct a spectral analysis of five of the 34 OIA-flagged IP candidates (IPCs) by fitting their 0.5 − 8.0 keV spectra with one- and two-temperature plasma models as well as a continuum plus Gaussians model for the Fe line emission observed between 6.0 − 7.0 keV. We use the best-fitting plasma temperatures and the Fe line intensity ratios to estimate white dwarf mass (MWD) for each IPC. We find MWD for three IPCs consistent with estimates for GC sources and nearby IPs, while two IPCs can be interpreted as IPs with low MW D or as a class of non-magnetic CV known as a dwarf nova.
A novel synthesis of dillapiol and its derivatives and their role as chemosensitizers and insecticide synergists.
Creators: name: Majerus, Sherry Lynn.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Health Sciences, Pharmacology.

description: The present work summarizes the results of a study done by Dr Claude Bernard on the effect of the natural lignan, dillapiol, on multidrug resistance phenotypes. In a tissue culture system, dillapiol was selectively toxic to hamster drug-resistant B30 cells; this same compound was substantially less toxic to the drug-sensitive AUXB1 cell line. The so-called collateral sensitivity of drug-resistant tumor cells to an otherwise benign lignan compound makes dillapiol an ideal candidate for an adjuvant in chemotherapy. Examination of the toxicity of dillapiol revealed no negative effects with respect to weight changes or behavior of the rats, no deaths, and no abnormalities of the brain, liver, heart, kidney and lungs. Moreover, a drug-fate study using $\sp $C-radiolabeled dillapiol showed that the lignan is available to the liver, kidney and gut and is excreted almost entirely via the urine. A novel synthesis of dillapiol which allows the incorporation of $\sp $C radioactivity in the final product is also discussed. The preparation of several dillapiol derivatives from either the intermediates of the dillapiol synthesis or from the modification of dillapiol itself is presented. (Abstract shortened by UMI.)
Non-trivial Topological Surface States Regulation of 1T-OsCoTe$_2$ Enables Selective C-C Coupling for Highly Efficient Photochemical CO$_2$ Reduction Toward C$_{2+}$ hydrocarbons
Creators: name: Wang, Kangwang
name: Wu, Mingjie
name: Yu, Peifeng
name: Garces, Hector F.
name: Liang, Ying
name: Li, Longfu
name: Zeng, Lingyong
name: Li, Kuan
name: Zhang, Chao
name: Yan, Kai
name: Luo, Huixia
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Despite ongoing research, the rational design of nontrivial topological semimetal surface states for the selective photocatalytic CO$_2$ conversion into valuable products remains full of challenges. Herein, we present the synthesis of 1T-OsCoTe$_2$ for the photoreduction upgrading of CO$_2$ to tricarbon alkane C$_3$H$_8$,by the integration of experimental work and theory calculation. Experimental studies suggested a high electron based selectivity of 71.2% for C$_3$H$_8$ and an internal quantum efficiency of 54.6% at 380 nm. In-situ X-ray photoelectron spectroscopy and X-ray absorption fine structure spectroscopy demonstrated that Co and Os atoms coordinated with Te atoms enable an efficient Os-Te-Co electron transfer to activate the generation of *CH$_3$,*CHOCO and *CH$_2$OCOCO. Density functional theory calculations further confirmed Os-Te-Co electron bridging on the improved CO$_2$ conversion kinetics. To our knowledge, this is the first report suggesting the role of Os atoms in accelerating the photocatalytic CO$_2$ conversion activity of the topological semimetal 1T-OsCoTe$_2$.
description: 31 pages, 6 Figures
Using the maternal immune stimulation model of schizophrenia to investigate the therapeutic efficacy of neuromodulation techniques
Creators: name: Hadar, Ravit
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: maternal immune stimulation model
subject: neuromodulation
subject: schizophrenia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The present work used a neurodevelopmental rodent model of schizophrenia, namely the maternal immune stimulation (MIS) model, to study the potency of electrical neuromodulation techniques to ameliorate and even prevent schizophrenia-relevant behavioral and neurobiological abnormalities. Acute and focal deep brain stimulation (DBS) to the medial prefrontal cortex (mPFC) was found to be therapeutically relevant as it successfully normalized deficits in sensorimotor gating and attention selectivity apparent in the adult MIS animals. Using a longitudinal approach the development of sensorimotor gating deficits in the MIS model was traced and was found to exhibit a maturational delay, in accordance with the clinical situation. Further, this approach revealed aberrant neurochemistry profile in the mPFC during the pre-symptomatic period of adolescence, prior to the outbreak of the behavioral deficits. Thus, chronic DBS to the mPFC of adolescent MIS animals was tested and revealed that this approach could prevent the development of deficits in sensorimotor gating, attentional selectivity and reversal learning. Along with these effects, DBS was able to prevent increased lateral ventricles volume and neurochemical alterations as well as the prevention of altered microglia in this model. Finally, a non-invasive neuromodulation technique in the form of transcranial direct current stimulation (tDCS) was chronically applied during adolescence to the prefrontal cortex and revealed that tDCS prevented behavioral deficits belonging to the positive-symptomatology of schizophrenia, along with abnormal lateral ventricles volume. Taken together, this pre-clinical, translational-directed work points to the plausible efficacy of early, non-invasive, neuromodulation approach as a preventive measure for the development of schizophrenia.
3794496.pdf
Creators: name: Yang, Jiamiao
name: Jingwei, Li
name: He, Sailing
name: Wang, Lihong
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Detailed description of the angular-spectrum method, the single-shot focusing-through DOPC experimental system, and the preparation of the dynamic scattering medium.
Hom-size identifiable subcategories of quiver representations for use in multi-parameter persistence theory
Creators: name: Diaz, Yariana
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: Persistence theory draws on quiver representations theory and homology to generate an algebraic summary, called a persistence diagram, which details the appearance and disappearance of topological features in a filtration of a topological space. It has applications in topological data analysis, where topological spaces may be be inferred from a sampling of data points. Once the information about the life of topological features is computed, their meaning can be inferred within the setting from which the original data was drawn. Introductions to the topic can be found in \cite{Oudot, BLintro2022, BOOsigned2023}. Topological data analysis has applications to a breadth of subjects and disciplines, including music theory, urban planning, machine learning, microbiology, physics, and economics.
description: When filtering a topological space by a single parameter, the theory of quiver representations completely describes how to decompose the resulting representation. The complexity increases significantly when filtering by two or more parameters. In particular, multi-parameter persistence yields quivers whose indecomposable representations are more complicated to describe. The theme of this work is to provide examples of subcategories of quiver representations (which will be determined by their indecomposable objects) whose objects can be distinguished from one another in a computationally feasible manner.
Comprehensive screening of polar emerging organic contaminants including PFASs and evaluation of the trophic transfer behavior in a freshwater food web
Creators: name: Fu, Qiuguo
name: Koschorreck, Jan
name: Meyer, Corina
name: Patrick, Michael
Publisher: name: My University
Year: 2022
Subjects: Nahrungskette
Biomagnifikation

description: Bioaccumulation and trophic transfer of persistent legacy contaminants have been intensively characterized, but little is known on the contaminants of emerging concern (CECs) in freshwater food webs. Herein, we comprehensively screened CECs with a focus on polar substances and further evaluated their trophic transfer behavior in selected items from the food web of Lake Templin, Germany. Weselected one plankton, two mussel, and nine fish samples covering three trophic levels. With an effective multi-residue sample preparation method and high-resolution mass spectrometry-based target, suspect, and non-target screening, we characterized 477 targets and further screened unknown features in complex biota matrices. Of the 477 targets, 145 were detected and quantified in at least one species (0.02-3640 ng/g, dry weight). Additionally, the suspect and non-target analysis with experimental mass spectra libraries and in silico techniques (MetFrag and SIRIUS4/CSI:FingerID) enabled further identification of 27 unknown compounds with 19 confirmed by reference standards. Overall, the detected compounds belong to a diverse group of chemicals, including 71 pharmaceuticals, 27 metabolites, 26 pesticides, 16 per- and polyfluoroalkyl substances (PFASs), 4 plasticizers, 3 flame retardants, 11 other industrial chemicals and 14 others. Moreover, we determined the trophic magnification factor (TMF) of 34 polar CECs with >80% detection frequency, among which 6 PFASs including perfluorooctane sulfonic acid (PFOS), perfluorodecanoic acid (PFDA), perfluorohexane sulfonic acid (PFHxS), perfluorotridecanoic acid (PFTrA), perfluorotetradecanoic acid (PFTeA), and perfluoroundecanoic acid (PFUnA), exhibited biomagnification potential (TMF =1.8 - 4.2, p < 0.05), whereas 5 pharmaceuticals (phenazone, progesterone, venlafaxine, levamisole, and lidocaine) and 1 personal care product metabolite (galaxolidone) showed biodilution potential (TMF = 0.4 - 0.6, p < 0.05). © 2022 The Authors
The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: Human-Biomonitoring

description: Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites in urine and mercury in hair. In the Danish participants, significant correlations between mothers and children for mercury in hair and cotinine in urine were found. Mercury in hair was further significantly associated with intake of fish and area of residence. Cadmium was positively associated with BMI in mothers and an association between cadmium and cotinine was also found. As expected high cotinine levels werefound in smoking mothers. For both mercury and cadmium significantly higher concentrations were found in the mothers compared to their children. In Denmark, the DEMOCOPHES project was co-financed by the Danish ministries of health, environment and food safety. The co-financing ministries agreed to finance a number of supplementary measurements of substances of current toxicological, public and regulatory interest. This also included blood sampling from the participants. The collected urine and blood samples were analyzed for a range of other persistent and non-persistent environmental chemicals as well as two biomarkers of effect. The variety of supplementary measurements gives the researchers further information on the exposure status of the participants and creates a basis for valuable knowledge on the pattern of exposure to various chemicals.Quelle: http://www.sciencedirect.com
Measurement of the high-Q$^2$ neutral current deep inelastic scattering cross sections with the ZEUS detector at HERA
Creators: name: Goncalo, Jose Ricardo Morais Silva
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2003
Subjects: thesis
electron p: colliding beams
positron p: colliding beams
electron p: deep inelastic scattering
neutral current
momentum transfer: high
differential cross section: x-dependence
momentum transfer dependence
p: structure function
electroweak interaction: validity test
ZEUS
experimental results
DESY HERA Stor
tables
bibliography
318 GeV-cms

description: University of London, Diplomarbeit, 2003; 229 pp., (2003). doi:10.3204/DESY-THESIS-2003-022
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Generation and applications of cascaded coherent sources of extreme ultraviolet
Creators: name: Tran, Khoa Anh
Publisher: name: Swinburne
Year: 2024

description: This dissertation reports the generation and applications of coherent extreme ultraviolet (XUV) sources. By using a long gas cell and multiple colour collinear femtosecond laser fields, we have observed for the first time phase-matched cascaded four-wave mixing processes in the XUV region. We apply these bright light sources in studies of the dynamics of the atomic gases, the extension of the high harmonic generation cutoff region, and the generation of XUV quasi-continuum spectrum. We also investigate the effects of a weak near infrared control field on the propagation of the XUV radiation when two commensurate fundamental lasers are used.
Effet d'un programme de formation en approche créative à la résolution de problèmes (CPS) sur les aptitudes créatives de l'infirmière et sur leur utilisation lors de l'application de son processus d'intervention.
Creators: name: Gravelle, Diane.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Education, Guidance and Counseling.

description: La présente étude de type quasi-experimental a pour but de démontrer l'effet d'un programme en approche créative à la résolution de problèmes (le "Creative Problem Solving" d'Osborn-Parnes "CPS") sur le développement d'aptitudes créatives chez l'étudiante-infirmière et sur son aptitude à appliquer le processus créatif de résolution de problèmes à des situations de soins infirmiers. La méthodologie employée a permis de mesurer l'effet d'un apprentissage expérientiel en approche créative de résolution de problèmes sur: (1) les aptitudes créatives des étudiantes-infirmières; (2) leur aptitude à reconnaître les problèmes de santé des patients; (3) leur aptitude à circonscrire des solutions adéquates à ces problèmes; (4) leur auto-évaluation en regard des traits de personnalité créative. Par la présente recherche, nous cherchons à faire ressortir la complicité entre l'approche créative à la résolution de problème et la démarche de soins traditionnellement enseignée dans les programmes de soins infirmiers. Habituellement, les étudiantes utilisent une démarche rationnelle à l'aide de données conscientes, logiques, qui ont un impact dans l'immédiat. Ainsi, plutôt que de scruter diverses facettes du problème et, partant, de générer plusieurs possibilités de nouvelles solutions, l'étudiante, au contraire, tente de trouver immédiatement la bonne solution de façon à s'assurer un bon résultat (Getzels, 1964; Lazure, 1980). En constatant les avantages de l'approche créative, nous sommes en mesure d'affirmer que le travail de la pensée divergente permettrait d'élargir les horizons de la cueillette des données en utilisant la totalité des informations sensorielles (comme le suggère Adams, 1989) pour être en mesure de bien analyser le problème du patient et trouver des solutions qui soient adaptées à sa personne. Tout en reconnaissant que d'autres recherches sont nécessaires pour offrir une meilleure généralisation des résultats, nous considérons qu'il est impérieux d'insérer dans tout programme de soins infirmiers des objectifs précis en matière de développement de la pensée créative et des aptitudes inhérentes à celle-ci. (Abstract shortened by UMI.)
title: Perspektiven für ein bundesweites Pollenmonitoring in Deutschland - fachübergreifender Arbeitskreis "Bundesweites Pollenmonitoring"
title: Perspektiven für ein bundesweites Pollenmonitoring in Deutschland
titleType: AlternativeTitle
title: Perspectives for a nationwide pollen monitoring in Germany: The Interdisciplinary Working Group "National Pollen Monitoring"
titleType: AlternativeTitle
Creators: name: Baeker, Regine
name: Bergmann, Karl-Christian
name: Buters, Jeroen
name: Höflich, Conny
name: Mücke, Hans-Guido
name: Straff, Wolfgang
Publisher: name: My University
Year: 2020
Subjects: Allergie
Vorhersage
Gesundheit
Messungen
Schadensvorsorge

description: Allergene Pollen sind natürliche, biologische luftgetragene Partikel und der Hauptauslöser allergischer Atemwegserkrankungen. Die Messung allergener Pollen ist Voraussetzung für die gesundheitliche Vorsorge und zeigt Veränderungen im Pollenspektrum an, wie sie zum Beispiel im Rahmen des Klimawandels zu erwarten sind. Das in Deutschland einzige bundesweite Pollenmessnetz wird durch die Stiftung Deutscher Polleninformationsdienst (PID) betrieben. Fortbestand und Weiterentwicklung (u. a. Hybrid-System aus manuellen und automatischen Pollenfallen) dieses Messnetzes sind finanziell jedoch nicht gesichert. Im Sommer 2017 formierte sich daher der fachübergreifende Arbeitskreis "Bundesweites Pollenmonitoring", um sich über diesbezügliche Perspektiven für Deutschland auszutauschen. Für den Austausch kam der Arbeitskreis zwischen November 2017 und Juni 2018 zu 3 Gesprächstagen mit jeweils unterschiedlichen Themenschwerpunkten zusammen. Die internen Protokolle zu den Gesprächstagen bildeten anschließend die Grundlage für die Erstellung des vorliegenden Positionspapiers, mit dem der Arbeitskreis seine Arbeit abschließt. Aufgrund der Bedeutung allergener Pollen für die menschliche Gesundheit und allergischer Erkrankungen für das Gesundheitssystem spricht sich der Arbeitskreis dafür aus, das bundesweite Pollenmonitoring in den Katalog staatlicher Aufgaben aufzunehmen, die der grundlegenden Versorgung der Bevölkerung mit wesentlichen Gütern und Dienstleistungen dienen (öffentliche Daseinsvorsorge). Hinsichtlich möglicher Zuständigkeiten im Rahmen der öffentlichen Daseinsvorsorge wurden im Arbeitskreis mehrere Lösungsansätze diskutiert. Unabhängig von der zukünftigen Zuständigkeit kommt der Kooperation von messtechnischen, klinischen und wissenschaftlichen Einrichtungen eine grundsätzliche Bedeutung für die adäquate gesundheitliche Vorsorge zu. Dieses Positionspapier des fachübergreifenden Arbeitskreises "Bundesweites Pollenmonitoring" ist eine Übernahme aus dem Bundesgesundheitsblatt [Bundesgesundheitsblatt 2019;62:652-61, https:// doi.org/10.1007/s00103- 019-02940-y]. Der Artikel wurde unter der Creative Commons Namensnennung 4.0 International Lizenz (http://creativecommons. org/licenses/ by/4.0/deed.de) veröffentlicht.
title: Health-Related Quality of Life in Children and Adolescents with Hereditary Bleeding Disorders and in Children and Adolescents with Stroke
title: Cross-Sectional Comparison to Siblings and Peers
titleType: Subtitle
Creators: name: Neuner, Bruno
name: Von Mackensen, Sylvia
name: Holzhauer, Susanne
name: Funk, Stephanie
name: Klamroth, Robert
name: Kurnik, Karin
name: Krümpel, Anne
name: Halimeh, Susan
name: Reinke, Sarah
name: Frühwald, Michael
name: Nowak-Göttl, Ulrike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives. To investigate self-reported health-related quality of life (HrQoL) in children and adolescents with chronic medical conditions compared with siblings/peers. Methods. Group 1 (6 treatment centers) consisted of 74 children/adolescents aged 8–16 years with hereditary bleeding disorders (HBD), 12 siblings, and 34 peers. Group 2 (one treatment center) consisted of 70 children/adolescents with stroke/transient ischemic attack, 14 siblings, and 72 peers. HrQoL was assessed with the “revised KINDer Lebensqualitätsfragebogen” (KINDL-R) questionnaire. Multivariate analyses within groups were done by one-way ANOVA and post hoc pairwise single comparisons by Student’s -tests. Adjusted pairwise comparisons were done by hierarchical linear regressions with individuals nested within treatment centers (group 1) and by linear regressions (group 2), respectively. Results. No differences were found in multivariate analyses of self-reported HrQoL in group 1, while in group 2 differences occurred in overall wellbeing and all subdimensions. These differences were due to differences between patients and peers. After adjusting for age, gender, number of siblings, and treatment center these differences persisted regarding self-worth () and friend-related wellbeing (). Conclusions. In children with HBD, HrQoL was comparable to siblings and peers. In children with stroke/TIA HrQoL was comparable to siblings while peers, independently of relevant confounder, showed better self-worth and friend-related wellbeing.
Effect of gut microbiota modulation during early-life and adulthood on host immunity
Creators: name: Lehman, Peter Cole
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: Humans and their gut microbiota have a symbiotic relationship where gut bacteria benefit the host and vice versa. However, when gut microbiota composition is altered, this symbiotic relationship can be disrupted, leading to an imbalance between pro-inflammatory and anti-inflammatory immune responses. In many cases, this imbalance can manifest as chronic inflammation and/or influence the pathobiology of human diseases. It is important to highlight that babies are born sterile and acquire gut microbiota as they grow. Specifically, the interaction between early-life gut microbiota and host immunity establishes the host immune framework for adult life, which can be fine-tuned by gut microbiota during adulthood. Thus, it is crucial to understand the factors that can modulate gut microbiota composition and their influence on host immunity in both early and adult life. In this study, we sought to understand how a commonly used herbicide, glyphosate, influenced adult microbiota composition and immune homeostasis and how early-life microbiota depletion affects host immunity later in life. In glyphosate-exposed mice, gut microbiota composition and function were altered, which was associated with effects on gut homeostasis. These effects were characterized by increased CD4+IL17A+ T cells and Lipocalin-2, a known marker of intestinal inflammation. The known beneficial bacteria, Lactobacillus and Bifidobacterium, were also decreased in glyphosate-exposed mice.
description: Furthermore, early-life antibiotic exposure caused complete microbiota depletion and resulted in altered host immunity. Mice who were exposed to antibiotics in early life exhibited significantly increased small intestinal RORγt+ T cells and increased pro-inflammatory cytokine production from CD11c+ DCs later in life. These immunological changes were also associated with exacerbated experimental autoimmune encephalomyelitis severity (EAE) and increased autoreactive T cell proliferation later in life. These studies underscore the immense sensitivity of the immune system and, thus, highlight the critical importance of maintaining a “healthy” gut microbiota where exposure to commonly used environmental toxicants or early-life microbiota modulation can significantly affect host immunity which can predispose to inflammatory diseases.