cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Κατανεμημένες εφαρμογές blockchain στον τομέα της υγείας
title: Distributed blockchain applications in health domain
titleType: AlternativeTitle
Creators: name: Καψής, Παναγιώτης
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Υγεία
Blockchain
Εφαρμογές

description: Η τεχνολογία έχει πραγματικά εισβάλει στη ζωή μας τα τελευταία χρόνια. Η τεχνολογία Blockchain είναι μια από τις πιο σημαντικές ανακαλύψεις και δημιουργικές εξελίξεις που διαδραματίζουν σημαντικό ρόλο στον επαγγελματικό κόσμο σήμερα. Το blockchain ως ολοκληρωμένη έννοια προέκυψε με το πρώτο κρυπτονόμισμα, το Bitcoin, ως τρόπος διατήρησης δεδομένων, διασφαλίζοντας πάντα τη μοναδικότητα και την εγκυρότητά του, χωρίς να εμπλέκεται καμία κεντρική ελεγκτική αρχή. Αυτή η τεχνολογία αναπτύσσεται προς την κατεύθυνση της συνεχούς επανάστασης και αλλαγής. Είναι ένα blockchain που επικαλύπτει πληροφορίες και διατηρεί την εμπιστοσύνη μεταξύ των ατόμων ανεξάρτητα από το πόσο μακριά βρίσκονται. Η άνοδος της τεχνολογίας ανάγκασε τους ακαδημαϊκούς και τους ειδικούς να εξετάσουν εξονυχιστικά νέους τρόπους εφαρμογής της τεχνολογίας blockchain σε ένα ευρύ φάσμα τομέων. Η τεχνολογία είναι σχετικά νέα, έχει αναπτυχθεί την τελευταία δεκαετία και χρησιμοποιείται στη νομοθεσία, τις ασφάλειες, στις επιστήμες υγείας, τις αλυσίδες εφοδιασμού, τη διαχείριση πνευματικών δικαιωμάτων και πολλούς άλλους τομείς πέρα από αυτόν που απέκτησε φήμη από τα κρυπτονομίσματα. Επιδεικνύει επίσης τις δυνατότητες της τεχνολογίας blockchain να φέρει επανάσταση στον κλάδο της υγειονομικής περίθαλψης. Στην παρούσα εργασία αναλύεται η τεχνολογία του Blockchain καθώς και οι εφαρμογές της στις επιστήμες υγείας. Στη συνέχεια αναφέρονται τύποι πρωτοκόλλων συναίνεσης και παρουσιάζονται διάφορα παραδείγματα χρήσης τους. Επιπλέον, αναλύεται ο ρόλος του κάθε ατόμου στην επιλογή μιας πλατφόρμας ανάπτυξης εφαρμογών blockchain καθώς και μερικές από τις πιο δημοφιλείς πλατφόρμες ανάπτυξης εφαρμογών.
Unveiling the cosmological QCD phase transition through the eLISA/NGO detector
Creators: name: Roque, V. R. C. Mourão
name: Lugones, G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the evolution of turbulence in the early universe at the QCD epoch using a state-of-the-art equation of state derived from lattice QCD simulations. Since the transition is a crossover we assume that temperature and velocity fluctuations were generated by some event in the previous history of the Universe and survive until the QCD epoch due to the extremely large Reynolds number of the primordial fluid. The fluid at the QCD epoch is assumed to be non-viscous, based on the fact that the viscosity per entropy density of the quark gluon plasma obtained from heavy-ion collision experiments at the RHIC and the LHC is extremely small. Our hydrodynamic simulations show that the velocity spectrum is very different from the Kolmogorov power law considered in studies of primordial turbulence that focus on first order phase transitions. This is due to the fact that there is no continuous injection of energy in the system and the viscosity of the fluid is negligible. Thus, as kinetic energy cascades from the larger to the smaller scales, a large amount of kinetic energy is accumulated at the smallest scales due to the lack of dissipation. We have obtained the spectrum of the gravitational radiation emitted by the motion of the fluid finding that, if typical velocity and temperature fluctuations have an amplitude $(Δv) /c \gtrsim 10^{-2}$ and/or $ΔT/T_c \gtrsim 10^{-3}$, they would be detected by eLISA at frequencies larger than $\sim 10^{-4}$ Hz.
description: to appear in Physical Review D
Union Seminary Quarterly Review, volume 41, issue 3-4 (1987)
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 1987
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: Articles “Paul Tillich: Depth Dimension of the Nuclear Age” by Ira Chernus, 1 “American Theology in the Shadow of the Bomb” by G. Clarke Chapman, Jr., 25 “Katsumi Takizawa: Approach Toward a World Theology: A Critical Exposition From a Process Perspective” by Tokiyuki Nobuhara, 39 “Dietrich Bonhoeffer: Encouragement of Human Love” by Terrence Reynolds, 55 “Theodicy After Auschwitz and The Reality of God” by Stephen Gottschalk, 77 “Aliens in the Promised Land?” by Gary David Comstock, 93 Book Reviews, 105 Books Received, 125 Index, 131
Die Gewalt der politischen Philosophie. Iris Därmann über Widerstand gegen Rassismus, Kolonialismus und Versklavung
Creators: name: Martinsen, Franziska
Publisher: name: Ethik und Gesellschaft
Year: 2021

description: Rezension von: Iris Därmann (2020): Undienlichkeit. Gewaltgeschichte und politische Philosophie. Berlin: Matthes Seitz. 510 S., ISBN 978-3-95757-874-7, EUR 38,00.
description: Ethik und Gesellschaft, Nr. 1 (2021): Pandemie-Nach-Denken
Die Wissenschaftsreligion als ein Religionstypus der europäischen Moderne. Die Religionssoziologie Wolfgang Eßbachs
Creators: name: Gärtner, Christel
Publisher: name: Ethik und Gesellschaft
Year: 2021

description: Rezension von: Wolfgang Eßbach (2019): Religionssoziologie 2. Entfesselter Markt und Artifizielle Lebenswelt als Wiege neuer Religionen, Teilband 1, Paderborn: Wilhelm Fink. 827 S., ISBN 978-3-7705-5820-9, EUR 249,00.
description: Ethik und Gesellschaft, Nr. 1 (2021): Pandemie-Nach-Denken
title: Endangered Species Act Section 7(a)(2) Biological Opinion, Letter of Concurrence and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the PacWave South Wave Energy Test Site (FERC No.: 14616), Newport, Oregon (Pacific Ocean HUC# 171002050800)
titleType: Other
Creators: name: United States. National Marine Fisheries Service
Publisher: name: United States. National Marine Fisheries Service
Year: 2019

description: ESA Section 7 Consultation ; WCRO-2019-03469
Numerical estimates on the Landau-Siegel zero and other related quantities
Creators: name: Languasco, Alessandro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11M20, 11-04, 11Y60

description: Let $q$ be a prime, $χ$ be a non-principal Dirichlet character $\bmod\ q$ and $L(s,χ)$ be the associated Dirichlet $L$-function. For every odd prime $q\le 10^7$, we show that $L(1,χ_\square) > c_{1} \log q$ and $β< 1- \frac{c_{2}}{\log q}$, where $c_1=0.0124862668\dotsc$, $c_2=0.0091904477\dotsc$, $χ_{\square}$ is the quadratic Dirichlet character $\bmod\ q$ and $β\in (0,1)$ is the Landau-Siegel zero, if it exists, of such a set of Dirichlet $L$-functions. As a by-product of the computations here performed, we also obtained some information about the Littlewood and Joshi bounds on $L(1,χ_\square)$ and on the class number of the imaginary quadratic field ${\mathbb Q}(\sqrt{-q})$.
description: 18 pages, 4 tables, 10 figures. Several typos corrected
title: A Revision of the North American Species in the Genus Euodynerus (Hymenoptera: Eumenidae)
Creators: name: Moalif, Ali Shallan
Publisher: name: Utah State University
Year: 1982

description: Twenty-eight species of Euodynerus Dalla Torre are recognized from the Nearctic Region, of which one is Holarctic. Literature on the biology of fourteen species is reviewed and new biological information discussed for four species. The phylogenetic relationships of the genus Euodynerus to other genera and the classification and relationships of the species of Euodynerus are discussed. Seven subgenera are recognized of which four are new: Euodynerus, Pareuodynerus Bluethgen, Leucodynerus Bohart, Annodynerus new subgenus, Gonodynerus n. subgenus, Holodynerus n. subgenus and Plecodynerus n. subgenus. Their comparative morphology, phylogeny, and distrubution are discussed. Larval instars of E. hidalgo (Saussure), E. scutellaris (Saussure), E. notatus (jurine) and mature larva of E. pratensis (Saussure) and E. congresus (Viereck) are compared. Keys, descriptions, illustrations, synonymical names, variation within species and distribution maps are presented. The male of E. megaera (Lepeletier) and the female of E. delicatus (Cresson) and E. digiticornis (Bohart) are newly discribed.
The following names are newly synonymized: E. alvarado alvarado (Saussure), E. alvarado afranus (Bohart), E. annulatus avensis (Saussure), E. annulatus evectus (Cresson), E. annulatus imperialis (Bohart) and E. annulatus sulphureus (Saussure) = E. annulatus (Say), E. provisoris (Viereck), E. tempiferus tempiferus (Viereck), E. tempiferus birepandus (Bohart), E. tempiferus eldoradensis (Rohwer), E. tempiferus pritchardi (Bequaert), and E. tempiferus subrueus (Bohart) = E. annectens (Saussure), E. auranus albivestis (Bohart), E. auranus equilus (Bohart) and E. auranus azotopus (Bohart) = E. auranus (Cameron), E. barberi (Bohart) = E. cluniculus (Saussure), E. boscii boharti (Krombein), E. b. molestus (Saussure) and E. guerrero (Saussure) = E. boscii (Lepeletier), E. castigatus rubrivestis (Bohart) and E. c. sanneovestis (Bohart) = E. castigatus, E. crypticus (Say), and E. crypticus stricklandi (Bequaert) = E. crypticus (Say), Odynerus orasus Camerson = E. delicatus (Cresson), E. exoglyphys albovittatus (Bohart) = E. exoglyphus (Bohart), E. schwarzi (Krombein) = E. foraminatus (Saussure), E. foraminatus aequalis (Cameron), O. santafeae (Cameron) and E. foraminatus blakeanus (Cameron) = E. scutellaris (Saussure), E. leucomelas leucomelas (Saussure), and E. l. oregonensis (Bohart), E. foraminatus apopkensis (Robertson) and E. f. parvirudis (Bohart) = E. notatus (Jurine), E. hidalgo viereckii (Cameron) and E. hidalgo boreoorientalis (Bequaert) = E. hidalgo (Saussure), E. pratensis brumalis (Bequaert) = E. pratensis (Saussure). E. foraminatus scutellaris is raised from subspecies to species status.
Integrable maps from Galois differential algebras, Borel transforms and number sequences
Creators: name: Tempesta, Piergiulio
Publisher: name: arXiv
Year: 2013
Subjects: subject: Dynamical Systems (math.DS)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: A new class of integrable maps, obtained as lattice versions of polynomial dynamical systems is introduced. These systems are obtained by means of a discretization procedure that preserves several analytic and algebraic properties of a given differential equation, in particular symmetries and integrability [40]. Our approach is based on the properties of a suitable Galois differential algebra, that we shall call a Rota algebra. A formulation of the procedure in terms of category theory is proposed. In order to render the lattice dynamics confined, a Borel regularization is also adopted. As a byproduct of the theory, a connection between number sequences and integrability is discussed.
description: 16 pages (to appear)
Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
Creators: name: Lan, Huan
name: Abualrous, Esam Tolba
name: Sticht, Jana
name: Fernandez, Laura Maria Arroyo
name: Werk, Tamina
name: Weise, Christoph
name: Ballaschk, Martin
name: Schmieder, Peter
name: Loll, Bernhard
name: Freund, Christian
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Antigen presentation
subject: Enzyme mechanisms
subject: MHC class I
subject: NMR spectroscopy
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: The repertoire of peptides presented by major histocompatibility complex class I (MHC-I) molecules on the cell surface is tailored by the ER-resident peptide loading complex (PLC), which contains the exchange catalyst tapasin. Tapasin stabilizes MHC-I molecules and promotes the formation of stable peptide-MHC-I (pMHC-I) complexes that serve as T cell antigens. Exchange of suboptimal by high-affinity ligands is catalyzed by tapasin, but the underlying mechanism is still elusive. Here we analyze the tapasin-induced changes in MHC-I dynamics, and find the catalyst to exploit two essential features of MHC-I. First, tapasin recognizes a conserved allosteric site underneath the α2-1-helix of MHC-I, ‘loosening’ the MHC-I F-pocket region that accomodates the C-terminus of the peptide. Second, the scoop loop11–20 of tapasin relies on residue L18 to target the MHC-I F-pocket, enabling peptide exchange. Meanwhile, tapasin residue K16 plays an accessory role in catalysis of MHC-I allotypes bearing an acidic F-pocket. Thus, our results provide an explanation for the observed allele-specificity of catalyzed peptide exchange.
A no-go result on the purification of quantum states
Creators: name: Di Franco, C.
name: Paternostro, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The information encoded in a quantum system is generally spoiled by the influences of its environment, leading to a transition from pure to mixed states. Reducing the mixedness of a state is a fundamental step in the quest for a feasible implementation of quantum technologies. Here we show that it is impossible to "transfer" part of such mixedness to a "trash" system without losing some of the initial information. Such loss is lower-bounded by a value determined by the properties of the initial state to purify. We discuss this interesting phenomenon and its consequences for general quantum information theory, linking it to the information theoretical primitive embodied by the quantum state-merging protocol and to the behaviour of general quantum correlations.
description: RevTeX4, 4+2 pages, 4 figures. Available at http://www.nature.com/srep/2013/130306/srep01387/full/srep01387.html
Zero-frequency noise in adiabatically driven, interacting quantum systems
Creators: name: Riwar, Roman-Pascal
name: Splettstoesser, Janine
name: König, Jürgen
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate current-current correlations of adiabatic charge pumping through interacting quantum dots weakly coupled to reservoirs. To calculate the zero-frequency noise for a time-dependently driven system, possibly in the presence of an additional dc bias, we perform within a real-time diagrammatic approach a perturbative expansion in the tunnel coupling to the reservoirs in leading and next-to-leading order. We apply this formalism to study the adiabatic correction to the zero-frequency noise, i.e., the pumping noise, in the case of a single-level quantum dot charge pump. If no stationary bias is applied, the adiabatic correction shows Coulomb-interaction-induced deviations from the fluctuation-dissipation theorem. Furthermore, we show that the adiabatic correction to the Fano factor carries information about the coupling asymmetry and is independent of the choice of the pumping parameters. When including a time-dependent finite bias, we find that there can be pumping noise even if there is zero adiabatically pumped charge. The pumping noise also indicates the respective direction of the bias-induced current and the pumping current.
Union Seminary Quarterly Review, volume 41, issue 2 (1987)
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 1987
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: Articles “Linguistic Self-Reference and Religious Language” by Peter H. Van Ness, 1 “A Genealogy of the Logic of Deterrence: Habermas, Foucault and a Feminist Ethic or Risk” by Sharon D. Welch, 13 “Moral Apologetics and the Nuclear Dilemma” by Jeffrey C. Eaton, 33 “Foundation vs. Scaffolding: The Possibility of Justification in a Historicist Approach to Ethics” by Linell E. Cady, 45 Book Reviews, 63
Robust Strong Lensing Time Delay Estimation
Creators: name: Hojjati, Alireza
name: Kim, Alex G.
name: Linder, Eric V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Strong gravitational lensing of time variable sources such as quasars and supernovae creates observable time delays between the multiple images. Time delays can provide a powerful cosmographic probe through the "time delay distance" involving the ratio of lens, source, and lens-source distances. However, lightcurves of lensed images have measurement gaps, noise, systematics such as microlensing from substructure along an image line of sight, and no a priori functional model, making robust time delay estimation challenging. Using Gaussian process techniques, we demonstrate success in accurate blind reconstruction of time delays and reduction in uncertainties for real data.
description: 6 pages, 3 figures; v2 improved results using damped random walk kernel, matches PRD version
Analysis of Spin-Orbit Misalignment in Eclipsing Binary DI Herculis
Creators: name: Philippov, Alexander A.
name: Rafikov, Roman R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Eclipsing binary DI Herculis (DI Her) is known to exhibit anomalously slow apsidal precession, below the rate predicted by the general relativity. Recent measurements of the Rossiter-McLauglin effect indicate that stellar spins in DI Her are almost orthogonal to the orbital angular momentum, which explains the anomalous precession in agreement with the earlier theoretical suggestion by Shakura. However, these measurements yield only the projections of the spin-orbit angles onto the sky plane, leaving the spin projection onto our line of sight unconstrained. Here we describe a method of determining the full three-dimensional spin orientation of the binary components relying on the use of the gravity darkening effect, which is significant for the rapidly rotating stars in DI Her. Gravity darkening gives rise to nonuniform brightness distribution over the stellar surface, the pattern of which depends on the stellar spin orientation. Using archival photometric data obtained during multiple eclipses spread over several decades we are able to constrain the unknown spin angles in DI Her with this method, finding that spin axes of both stars lie close to the plane of the sky. Our procedure fully accounts for the precession of stellar spins over the long time span of observations.
description: Accepted by ApJ, 12 pages, 10 figures
Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma
Creators: name: Bräunlein, Eva
name: Lupoli, Gaia
name: Füchsl, Franziska
name: Abualrous, Esam Tolba
name: Krätzig, Niklas De Andrade
name: Gosmann, Dario
name: Wietbrock, Lukas
name: Lange, Sebastian
name: Lan, Huan
name: Freund, Christian
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: immunotherapy
subject: adoptive
subject: adaptive immunity
subject: antigens
subject: neoplasm
subject: CD8-positive T-lymphocytes
subject: receptors
subject: immunologic
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Background Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in personalized medicine, although many aspects of their quality and associated immune responses are not yet well understood. In a case study of metastatic malignant melanoma, we aimed to perform an in-depth characterization of neoantigens and respective T-cell responses in the context of immune checkpoint modulation. Methods Three neoantigens, which we identified either by immunopeptidomics or in silico prediction, were investigated using binding affinity analyses and structural simulations. We isolated seven T-cell receptors (TCRs) from the patient’s immune repertoire recognizing these antigens. TCRs were compared in vitro by multiparametric analyses including functional avidity, multicytokine secretion, and cross-reactivity screenings. A xenograft mouse model served to study in vivo functionality of selected TCRs. We investigated the patient’s TCR repertoire in blood and different tumor-related tissues over 3 years using TCR beta deep sequencing. Results Selected mutated peptide ligands with proven immunogenicity showed similar binding affinities to the human leukocyte antigen complex and comparable disparity to their wild-type counterparts in molecular dynamic simulations. Nevertheless, isolated TCRs recognizing these antigens demonstrated distinct patterns in functionality and frequency. TCRs with lower functional avidity showed at least equal antitumor immune responses in vivo. Moreover, they occurred at high frequencies and particularly demonstrated long-term persistence within tumor tissues, lymph nodes and various blood samples associated with a reduced activation pattern on primary in vitro stimulation. Conclusions We performed a so far unique fine characterization of neoantigen-specific T-cell responses revealing defined reactivity patterns of neoantigen-specific TCRs. Our data highlight qualitative differences of these TCRs associated with function and longevity of respective T cells. Such features need to be considered for further optimization of neoantigen targeting including adoptive T-cell therapies using TCR-transgenic T cells.
Estimating the Instantaneous Reproduction Number With Imperfect Data: A Method to Account for Case-Reporting Variation and Serial Interval Uncertainty
Creators: name: Hettinger, Gary
name: Rubin, David
name: Huang, Jing
Publisher: name: arXiv
Year: 2023
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: During an infectious disease outbreak, public health decision-makers require real-time monitoring of disease transmission to respond quickly and intelligently. In these settings, a key measure of transmission is the instantaneous time-varying reproduction number, $R_t$. Estimation of this number using a Time-Since-Infection model relies on case-notification data and the distribution of the serial interval on the target population. However, in practice, case-notification data may contain measurement error due to variation in case reporting while available serial interval estimates may come from studies on non-representative populations.
 We propose a new data-driven method that accounts for particular forms of case-reporting measurement error and can incorporate multiple partially representative serial interval estimates into the transmission estimation process. In addition, we provide practical tools for automatically identifying measurement error patterns and determining when measurement error may not be adequately accounted for. We illustrate the potential bias undertaken by methods that ignore these practical concerns through a variety of simulated outbreaks. We then demonstrate the use of our method on data from the COVID-19 pandemic to estimate transmission and explore the relationships between social distancing, temperature, and transmission.
Supersonic Flutter of a Plate Containing Many Bays in the Spanwise Direction
Creators: name: Cummings, Benjamin Edgar
Publisher: name: California Institute of Technology
Year: 1957
Subjects: Supersonic flutter
Aeronautics
aeronautics
aeronautical engineering

description: A special problem of panel flutter is considered by the method of Galerkin. The solution to the supersonic, non-steady potential equation is obtained by the approach of Garrick and Rubinow. Plate equations of motion are obtained by use of the Lagrange equations. Numerical solutions to the flutter determinant are presented for two cases.
Testing of Cryogenic Photomultiplier Tubes for the MicroBooNE Experiment
Creators: name: Briese, T.
name: Bugel, L.
name: Conrad, J. M.
name: Fournier, M.
name: Ignarra, C.
name: Jones, B. J. P.
name: Katori, T.
name: Navarrete-Perez, R.
name: Nienaber, P.
name: McDonald, T.
name: Musolf, B.
name: Prakash, A.
name: Shockley, E.
name: Smidt, T.
name: Swanson, K.
name: Toups, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The MicroBooNE detector, to be located on axis in the Booster Neutrino Beamline (BNB) at the Fermi National Accelerator Laboratory (Fermilab), consists of two main components: a large liquid argon time projection chamber (LArTPC), and a light collection system. Thirty 8-inch diameter Hamamatsu R5912-02mod cryogenic photomultiplier tubes (PMTs) will detect the scintillation light generated in the liquid argon (LAr). This article first describes the MicroBooNE PMT performance test procedures, including how the light collection system functions in the detector, and the design of the PMT base. The design of the cryogenic test stand is then discussed, and finally the results of the cryogenic tests are reported.
description: 17 pages, 14 figures, submitted to JINST
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
Creators: name: Abualrous, Esam Tolba
name: Stolzenberg, Sebastian
name: Sticht, Jana
name: Wieczorek, Marek
name: Roske, Yvette
name: Günther, Matthias
name: Dähn, Steffen
name: Boesen, Benedikt B.
name: Martínez Calvo, Marcos
name: Biese, Charlotte
name: Kuppler, Frank
name: Medina-García, Álvaro
name: Álvaro-Benito, Miguel
name: Höfer, Thomas
name: Noé, Frank
name: Freund, Christian
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Enzyme mechanisms
subject: Immunology
subject: FOS: Clinical medicine
subject: NMR spectroscopy
subject: Peptides
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II) proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large degree of allelic polymorphism influencing the peptide repertoire presented by the resulting MHC-II protein allotypes. During antigen processing, the human leukocyte antigen (HLA) molecule HLA-DM (DM) encounters these distinct allotypes and catalyzes exchange of the placeholder peptide CLIP by exploiting dynamic features of MHC-II. Here, we investigate 12 highly abundant CLIP-bound HLA-DRB1 allotypes and correlate dynamics to catalysis by DM. Despite large differences in thermodynamic stability, peptide exchange rates fall into a target range that maintains DM responsiveness. A DM-susceptible conformation is conserved in MHC-II molecules, and allosteric coupling between polymorphic sites affects dynamic states that influence DM catalysis. As exemplified for rheumatoid arthritis, we postulate that intrinsic dynamic features of peptide–MHC-II complexes contribute to the association of individual MHC-II allotypes with autoimmune disease.
First Neutron Spectrometry Measurement at the HL-2A Tokamak
Creators: name: Xi, Yuan
name: Xing, Zhang
name: Xufei, Xie
name: Zhongjing, Chen
name: Xingyu, Peng
name: Tieshuan, Fan
name: Jinxiang, Chen
name: Xiangqing, Li
name: Guoliang, Yuan
name: Jinwei, Yang
name: Qingwei, Yang
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A compact neutron spectrometer based on the liquid scintillator is presented for neutron energy spectrum measurements at the HL-2A tokamak. The spectrometer was well characterized and a fast digital pulse shape discrimination software was developed using the charge comparison method. A digitizer data acquisition system with a maximum frequency of 1 MHz can work under an environment with a high count rate at HL-2A tokamak. Specific radiation and magnetic shielding for the spectrometer were designed for the neutron spectrum measurement at the HL-2A tokamak. For pulse height spectrum analysis, dedicated numerical simulation utilizing NUBEAM combined with GENESIS was performed to obtain the neutron energy spectrum. Subsequently, the transportation process from the plasma to the detector was evaluated with Monte Carlo calculations. The distorted neutron energy spectrum was folded with the response matrix of the liquid scintillation spectrometer, and good consistency was found between the simulated and measured pulse height spectra. This neutron spectrometer based on a digital acquisition system could be well adopted for the investigation of the auxiliary heating behavior and the fast-ion related phenomenon on different tokamak devices.
description: 17 pages,9 figures
title: Επικοινωνιακές ικανότητες νηπίων με Σύνδρομο Williams
title: Communication skills of toddlers with Williams Syndrome
titleType: AlternativeTitle
Creators: name: Αρβανίτη, Χριστίνα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Σύνδρομο Williams
Συνεργατική επικοινωνία
Μητρική ομιλία
Ρυθμός επικοινωνίας

description: Σύμφωνα με την παρούσα πτυχιακή εργασία, τα παιδιά με Σύνδρομο Williams (ΣW) ξεχωρίζουν από τον υπόλοιπο κόσμο λόγω έλλειψης ενός τμήματος στο χρωμόσωμα 7. Το συγκεκριμένο σύνδρομο αποτελεί μια νευροαναπτυξιακή διαταραχή και τα άτομα που πάσχουν εμφανίζουν μέτρια νοητική αναπηρία. Αρχικά, είχε θεωρηθεί πως οι πάσχοντες διατηρούν τις επικοινωνιακές τους ικανότητες. Σκοπός της παρούσας εργασίας είναι η διεξοδική μελέτη των επικοινωνιακών ικανοτήτων νηπίων με σύνδρομο Williams. Σχετικά με την μέθοδο, χρησιμοποιείται ποιοτική έρευνα, με συμμετέχοντες 5 νήπια με ΣW ηλικίας 38-89 μηνών που συγκρίθηκαν με 5 τυπικά αναπτυσσόμενα (ΤΑ) παιδιά ηλικίας 17-49 μηνών, αντίστοιχου επιπέδου λεκτικής και μη λεκτικής νοημοσύνης. Τα παιδιά μαγνητοσκοπήθηκαν σε συνθήκη ελεύθερου παιχνιδιού με τις μητέρες τους στο περιβάλλον του σπιτιού. Ακολούθησε μικροανάλυση των μη λεκτικών συμπεριφορών των παιδιών και των μητέρων, ενώ αναλύθηκε και η λειτουργία των λεκτικών φράσεων των μητέρων. Τα αποτελέσματα δείχνουν πως τα νήπια με ΣW αφιερώνουν περισσότερο χρόνο σε συνεργατικό παιχνίδι σε σύγκριση με τα ΤΑ παιδιά. Ωστόσο, στην ομάδα ΣW το σύνολο των επεισοδίων συνεργατικού παιχνιδιού είναι κατευθυνόμενο, καθώς ακολουθεί μετά από κατευθυντήρια φράση της μητέρας. Οι μητέρες των παιδιών με ΣW χρησιμοποιούν περισσότερες κατευθυντήριες φράσεις από ότι οι μητέρες των ΤΑ παιδιών. Επιπλέον, το διάστημα που μεσολαβεί μεταξύ της κατευθυντήριας φράσης της μητέρας και της ανταπόκρισης του παιδιού είναι μεγαλύτερο στα νήπια με ΣW σε σύγκριση με τα ΤΑΝ. Το ποσοστό βλεμματικής επαφής κατά τη συνεργατική επικοινωνία είναι μεγαλύτερο στα παιδιά ΤΑ. Τέλος, τα ΤΑ παιδιά εμφανίζουν ομαλές μεταβολές στον αλληλοσυντονισμό της προσοχής στη διάρκεια του χρόνου, συγκριτικά με τα παιδιά με ΣW που παρουσιάζουν απότομες μεταβολές. Η συζήτηση επικεντρώνεται σε πιθανές ερμηνείες των σοβαρών προβλημάτων στις επικοινωνιακές ικανότητες νηπίων με ΣW και στην ανάγκη διερεύνησης ευαίσθητων δεικτών για τη μελέτη τους.
Research Roadmap
Creators: name: Invest In Open Infrastructure
Publisher: name: Zenodo
Year: 2022
Subjects: open infrastructure
scholarly communication
financial sustainability
open science
scholarly publishing

description: The Invest in Open Infrastructure (IOI) Research Roadmap is a continuously updated, working document that brings strategy closer to the day-to-day work of IOI by linking the elements in the Strategic Roadmap to key research questions. We also track status (in development, being scoped, etc) and related deliverables, linking both to the tangible research outputs of IOI as well as to the Strategic Roadmap and the Strategic Plan. This is intended to outline our research objectives and key activities on a quarterly basis. More info: https://investinopen.org/blog/sharing-our-strategic-and-research-roadmaps/
description: This work was funded by Arcadia, a charitable fund of Lisbet Rausing and Peter Baldwin. Additional information about how our work is funded can be found here: https://investinopen.org/about/how-were-funded/
title: New health-based guidance values for the industrial chemicals PFOS and PFOA: BfR Opinion No 032/2019 of 21 August 2019
Creators: name: Bundesinstitut Für Risikobewertung
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2019
Subjects: subject: 000

description: BfR-Stellungnahmen, vol. 2019, no. 032
Unfolding the Toric Code Model with Emergent Qubits
Creators: name: Kumar, Brijesh
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present the idea of emergent qubits by an exact model construction on a trestle, also generalized to arbitrary graphs. The corresponding eigenstates are quantum paramagnetic, with free multipolar moments. We rigorously transform the toric code model on a torus, cylinder and sheet into emergent qubits, writing all the eigenstates exactly. We devise exact quantum circuits for the toric code and other eigenstates described here. The depth of the circuit for toric code eigenstates on torus grows linearly with the total number of qubits, as compared to the sublinear growth on cylinder or sheet.
description: 9 pages, 7 captioned figures
Measurements of differential jet cross sections in proton-proton collisions at sqrt(s) = 7 TeV with the CMS detector
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Measurements of inclusive jet and dijet production cross sections are presented. Data from LHC proton-proton collisions at sqrt(s) = 7 TeV, corresponding to 5.0 inverse femtobarns of integrated luminosity, have been collected with the CMS detector. Jets are reconstructed up to rapidity 2.5, transverse momentum 2 TeV, and dijet invariant mass 5 TeV, using the anti-kt clustering algorithm with distance parameter R = 0.7. The measured cross sections are corrected for detector effects and compared to perturbative QCD predictions at next-to-leading order, using five sets of parton distribution functions.
description: Replaced with published version. Added journal reference and DOI
Resolving power: A general approach to compare the distinguishing ability of threshold-free evaluation metrics
Creators: name: Beam, Colin S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Selecting an evaluation metric is fundamental to model development, but uncertainty remains about when certain metrics are preferable and why. This paper introduces the concept of *resolving power* to describe the ability of an evaluation metric to distinguish between binary classifiers of similar quality. This ability depends on two attributes: 1. The metric's response to improvements in classifier quality (its signal), and 2. The metric's sampling variability (its noise). The paper defines resolving power generically as a metric's sampling uncertainty scaled by its signal. A simulation study compares the area under the receiver operating characteristic curve (AUROC) and the and the area under the precision-recall curve (AUPRC) in a variety of contexts. It finds that the AUROC generally has greater resolving power, but that the AUPRC is better when searching among high-quality classifiers applied to low prevalence outcomes. The paper also proposes an empirical method to estimate resolving power that can be applied to any dataset and any initial classification model. The AUROC is useful for developing the resolving power concept, but it has been criticized for being misleading. Newer metrics developed to address its interpretative issues can be easily incorporated into the resolving power framework. The best metrics for model search will be both interpretable and high in resolving power. Sometimes these objectives will conflict and how to address this tension remains an open question.
description: 23 pages, 9 figures, 3 tables
Union Seminary Quarterly Review, volume 42, issue 4 (1988)
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 1988
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: A Note from the Editor, 1 Articles “On the Form and Ethos of Ephesians” by Holland Hendrix, 3 Inaugural Essays “Preaching on the Eve of a New Millennium” by James A. Forbes, Jr., 17 “The Public Vocation of an Eschatological Community” by Larry Rasmussen, 25 “The Grace of Interruptions: Toward a New Vision of Christian History” by James Melvin Washington, 37 Book Reviews, 55 Contributors, 78
An Investigation of the Application of the Rayleigh-Ritz Method to the Deflection of a Small Aspect Ratio Swept Plate of Uniform Thickness
Creators: name: Wechsler, Joseph Wolff
Publisher: name: California Institute of Technology
Year: 1950
Subjects: Aeronautical engineering
Aeronautics

description: An investigation was initiated to examine the possibility of improving the rate of convergence of a series solution for the deflection of a swept cantilever plate of uniform thickness, using the Rayleigh-Ritz method, by applying the solution to low aspect ratio plates instead of high aspect ratio plates as had been done previously. The Rayleigh-Ritz deflection functions which were used were products of vibration modes of uniform clamped-free and free-free bars.

Deflections were computed, using six terms in the series, for three different loading conditions at sweep angles of 20°, 40°, and 60°. The results, plotted against experimental data in Figures 7 to 24, show that the rate of convergence is satisfactory only for angles of sweep of 20° or less. Since the cases of sweep of 20° or more are of most interest in the application to swept back aircraft wings, it was concluded that the rate of convergence is not satisfactory.

The possibility of improving the rate of convergence of the series solution by solving for the difference between the true deflections and the deflections given by some approximate formula was indicated as the next step in arriving at a satisfactory solution. It was pointed out that the experimental data mentioned above would provide a valuable guide in the formulation of such an approximate formula.
Research Roadmap
Creators: name: Invest In Open Infrastructure
Publisher: name: Zenodo
Year: 2023
Subjects: open infrastructure
scholarly communication
financial sustainability
open science
scholarly publishing

description: The Invest in Open Infrastructure (IOI) Research Roadmap is a continuously updated, working document that brings strategy closer to the day-to-day work of IOI by linking the elements in the Strategic Roadmap to key research questions. We also track status (in development, being scoped, etc) and related deliverables, linking both to the tangible research outputs of IOI as well as to the Strategic Roadmap and the Strategic Plan. This is intended to outline our research objectives and key activities on a quarterly basis. More info: https://investinopen.org/blog/sharing-our-strategic-and-research-roadmaps/
description: This work was funded by Arcadia, a charitable fund of Lisbet Rausing and Peter Baldwin. Additional information about how our work is funded can be found here: https://investinopen.org/about/how-were-funded/
Coherence of countably many bets
Creators: name: Stern, Rafael Bassi
name: Kadane, Joseph Born
Publisher: name: arXiv
Year: 2013
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60A05

description: De Finetti's betting argument is used to justify finitely additive probabilities when only finitely many bets are considered. Under what circumstances can countably many bets be used to justify countable additivity? In this framework, one faces issues such as the convergence of the returns of the bet. Generalizations of de Finetti's argument depend on what type of conditions on convergence are required of the bets under consideration. Two new such conditions are compared with others presented in the literature.
description: 15 pages
title: BfR2GO - Ausgabe 2/2019: Schwerpunkt Mikroplastik in Lebensmitteln
Creators: name: Bundesinstitut Für Risikobewertung
Publisher: name: Bundesinstitut für Risikobewertung
Year: 2019
Subjects: subject: 500

description: Wissenschaftsmagazin, vol. 2, 2019
Z2 peak of noise correlations in a quantum spin Hall insulator
Creators: name: Edge, Jonathan M.
name: Li, Jian
name: Delplace, Pierre
name: Büttiker, Markus
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the current noise correlations at a quantum point contact in a quantum spin Hall structure, focusing on the effect of a weak magnetic field in the presence of disorder. For the case of two equally biased terminals we discover a robust peak: the noise correlations vanish at $B = 0 $ and are negative for $B\not = 0 $. We find that the character of this peak is intimately related to the interplay between time reversal symmetry and the helical nature of the edge states and call it the Z2 peak.
description: 4+epsilon pages, 3 figures
Investigation of errors obtained with reflection-plane mounted models due to end plate tares
Creators: name: Miller, Herman
Publisher: name: California Institute of Technology
Year: 1948
Subjects: Aeronautics
reflection-plane mounted models

description: Because of the great interest in and emphasis on high-speed wind-tunnel tests, it has become increasingly important to provide a support system which affects the tunnel flow and the flow over the model as little as possible. One type of support which is being used a great deal at the present time is the so-called reflection-plane mount. This mount derives its name from the fact that the model consists of only half of the prototype wing or airplane, mounted on its plane of symmetry. Ordinarily the model is mounted next to one of the tunnel walls, but many variations of mounting have been used. A circular end plate may or may not be mounted as a metrical portion of the installation.

The purpose of the tests, described in this report, was to determine the interference effects of the tunnel wall or end plate on the model, the interference effects of the model on the end plate, and the true forces acting on the model and end plate. It was also desired to determine the forces acting on the portion of the model in the boundary layer and to determine the effects of gaps between the wing and end plate and between the end plate and tunnel wall.
Union Seminary Quarterly Review, volume 42, issue 3 (1988)
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 1988
Subjects: subject: Religion
subject: Spirituality
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Theology

description: Articles “The Redemptive Politic of Henry George: A Legacy to the Social Gospel” by Eileen W. Lindner, 1 “Neighbors and Missionaries: the Development of the Catholic Social Settlement Movement” by Margaret M. McGuiness, 9 “Richard T. Ely: Herald of a Positive State” by Eugene Y. Lowe, Jr., 21 “Church History as a Dialogue Partner in the Quest for a Christian Identity” by Mark G. Toulouse, 31 “Samuel Guy Inman: Venturer in Inter-American Friendship” by Karla Koll, 45 Book Reviews, 67
Saturation of Stellar Winds from Young Suns
Creators: name: Suzuki, Takeru K.
name: Imada, Shinsuke
name: Kataoka, Ryuho
name: Kato, Yoshiaki
name: Matsumoto, Takuma
name: Miyahara, Hiroko
name: Tsuneta, Saku
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: We investigate mass losses via stellar winds from sun-like main sequence stars with a wide range of activity levels. We perform forward-type magnetohydrodynamical numerical experiments for Alfven wave-driven stellar winds with a wide range of the input Poynting flux from the photosphere. Increasing the magnetic field strength and the turbulent velocity at the stellar photosphere from the current solar level, the mass loss rate rapidly increases at first owing to the suppression of the reflection of the Alfven waves. The surface materials are lifted up by the magnetic pressure associated with the Alfven waves, and the cool dense chromosphere is intermittently extended to 10 -- 20 % of the stellar radius. The dense atmospheres enhance the radiative losses and eventually most of the input Poynting energy from the stellar surface escapes by the radiation. As a result, there is no more sufficient energy remained for the kinetic energy of the wind; the stellar wind saturates in very active stars, as observed in Wood et al. The saturation level is positively correlated with B_{r,0}f_0, where B_{r,0} and f_0 are the magnetic field strength and the filling factor of open flux tubes at the photosphere. If B_{r,0}f_0 is relatively large >~ 5 G, the mass loss rate could be as high as 1000 times. If such a strong mass loss lasts for ~ 1 billion years, the stellar mass itself is affected, which could be a solution to the faint young sun paradox. We derive a Reimers-type scaling relation that estimates the mass loss rate from the energetics consideration of our simulations. Finally, we derive the evolution of the mass loss rates, \dot{M} t^{-1.23}, of our simulations, combining with an observed time evolution of X-ray flux from sun-like stars, which is shallower than \dot{M} t^{-2.33+/-0.55} in Wood et al.(2005).
description: 21 pages, 16 figures embedded, PASJ in press
Some experiments in nucleate boiling heat transfer
Creators: name: Gates, Chester Wright
Publisher: name: California Institute of Technology
Year: 1954
Subjects: Aeronautics

description: The present series of experiments was designed to provide additional information on the mechanism of bubble formation in boiling liquids. In particular, knowing that a pre-pressurization treatment raises the boiling temperature of a body of water markedly, it was desired to determine the effect of such treatment on boiling from a metal heating surface immersed in the water.

A 0.010" nichrome wire was immersed in a vessel of water, the entire assembly having been cleaned, and subjected to a pressure of 15000 psi for periods of time in excess of 15 minutes. The pressure was reduced to atmospheric and the wire heated to burnout by electric current. It was concluded that the effect of the treatment on the maximum heat transfer was small and equivalent to degassing the water.

A second series of experiments was conducted in which the temperature of the wire at the onset of boiling in pre-pressurized water was measured. These experiments indicated that the wire reached a temperature considerably in excess of normal nucleation temperatures, dropping to normal at the instant of nucleation. This effect could be explained in terms of the theory which postulates bubble formation from pre-existing gas or vapor nuclei.