cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
NMR-spektroskopische und chromatographische Untersuchungen zur Bestimmung des Struktur- und Diffusionsverhaltens von amphiphilen Poly-2-oxazolinen, Homo- und Copolymeren
Creators: name: Grabe, Bastian
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: Polymere
subject: Analytik
subject: NMR
subject: DOSY
subject: LC-NMR
subject: Chromatographie
subject: 540
subject: Polymere

description: Die NMR-Spektroskopie, als eine der vielfältigsten Methoden der Analytik, hilft dabei Probleme von chemischem Interesse zu lösen und das Verständnis zu erweitern. Diese Arbeit beschäftigt sich mit der Untersuchung der chemischen und physikalischen Eigenschaften von Polymeren mittels NMR-Spektroskopie unter Verwendung bekannter Methoden sowie neu entwickelter Applikationen. Besonderer Fokus liegt dabei auf der Diffusion Ordered Spectroscopy (DOSY). Für die Untersuchung von mizellaren Systemen wurden amphiphile Poly-2-oxazolin Block-Copolymere synthetisiert, die in wässriger Lösung Mizellen ausbilden. Es wurden hydrodynamische Radien als auch die Anteile der Mizellen in Lösung unter variablen Bedingungen bestimmt, um so die Abhängigkeit der physikalischen Eigenschaften von der chemischen Struktur zu verstehen. Zudem wurde in dieser Arbeit eine alternative Methode, basierend auf Diffusion Ordered Spectroscopy in Verbindung mit der inversen Laplace Transformation (ILT) entwickelt. werden. Die ermittelten 1H-Signalabfälle des DOSY-Experiments wurden mit Hilfe der ILT in eine Diffusionskoeffizientenverteilung des Polymers überführt. Die neu entwickelte DOSY-ILT Methode konnte erfolgreich an PS-b-PMMA Copolymeren etabliert und mit der chromatographischen Analyse verglichen werden. Für die Auftrennung und Analyse einer Oligostyrolmischung wurde eine neue Kopplung von LC und NMR entwickelt. Die 3D-LC-DOSY Experimente lieferten für die Charakterisierung der Substanzen hydrodynamische Radien, Molmassen sowie die Zusammensetzung der Analyten.
Glucocorticoid effects on oxidative stress and mitochondrial dysfunction
Creators: name: Tang, Victor Mark
Publisher: name: University of British Columbia
Year: 2012

description: Background: Many major psychiatric illnesses have been associated with aberrant stress response systems. In particular, those with mood disorders have been found to have an excessive and prolonged release of glucocorticoid stress hormones. Studies have also begun to reveal increased oxidative damage through mitochondrial dysfunction as part of the pathophysiology of such disorders. As both behaviorally induced stress and glucocorticoid treatment can increase the production of reactive oxygen species, this study aims to look at the effects of glucocorticoids on protein oxidative damage, mitochondrial function, and antioxidant activity. Methods: The effects of chronic treatment with corticosterone on cultured rat PC12 cells were examined. Protein oxidative damage was measured using both a spectrophotometric and immunoblotting method for protein carbonylation. Activity of the mitochondrial electron transport chain protein was examined through spectrophotometric techniques that measured complex I by quantifying NADH oxidation and complex III by cytochrome C reduction. Total antioxidant capacity (TAC) was measured to assess intracellular antioxidant capacity using a spectrophotometric assay. Results: It was found that chronic treatment with corticosterone was able to increase the amount of protein carbonylation in PC12 cells. Complex I activity, but not complex III, was decreased with drug treatment. TAC did not show any significant differences at doses which affected carbonylation or complex I activity. Limitations: The effects found with the time course and dosage of glucocorticoid treatment used here in cultured cells may be different then those found in normal or pathophysiological human conditions. Further research should also determine whether there are significant effects on neuronal function. Conclusions: Excessive glucocorticoid activity can decrease mitochondrial activity, leading to oxidative damage. Thus, over-active stress response systems and oxidative stress may be interrelated in the neurobiology of mood disorders, and may underlie neuronal pathophysiology in associated diseases. Moreover, chronic psychological stress could lead to detrimental effects on the brain through protein oxidation and mitochondrial dysfunction. Elucidation of these processes may open new possibilities for psychiatric treatments.
Thermal Transport Properties of Graphene-Based F/S/F Junctions
Creators: name: Salehi, Morteza
name: Alidoust, Mohammad
name: Rahnavard, Yousef
name: Rashedi, Gholamreza
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present an investigation of heat transport in gapless graphene-based Ferromagnetic /singlet Superconductor/Ferromagnetic (FG$\mid$SG$\mid$FG) junctions. We find that unlike uniform increase of thermal conductance vs temperature, the thermal conductance exhibits intensive oscillatory behavior vs width of the sandwiched s-wave superconducting region between the two ferromagnetic layers. This oscillatory form is occurred by interference of the massless Dirac fermions in graphene. Also we find that the thermal conductance vs exchange field $h$ displays a minimal value at $h/E_F\simeq 1$ within the low temperature regime where this finding demonstrates that propagating modes of the Dirac fermions in this value reach at their minimum numbers and verifies the previous results for electronic conductance. We find that for thin widths of superconducting region, the thermal conductance vs temperature shows linear increment i.e. $Γ\varpropto T$. At last we propose an experimental set-up to detect our predicted effects.
description: 6 pages, 6 figures
Additional file 3 of Endoscopic sinus surgery (ESS) to change quality of life for adults with recurrent rhinosinusitis: study protocol for a randomized controlled trial
Creators: name: Kaski, Heidi M.
name: Alakärppä, Antti
name: Lantto, Ulla
name: Laajala, Aleksi
name: Tokola, Paulus
name: Penna, Tomi
name: Ohtonen, Pasi
name: Alho, Olli-Pekka
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Lund-Mackay stage and Lund-Kennedy score forms. Radiological and endoscopical assessment forms that an attending member of the research team fills during hospital visits.
DESCRIPTION OF URBAN AGGLOMERATIONS OF THE REPUBLIC OF UZBEKISTAN
Creators: name: Kuvondikova, Hamida
Publisher: name: Zenodo
Year: 2023

description: Today, as a result of the use of geocity constructions, large-scale works are being carried out in order to improve the socio-economic lifestyle of the population in our republic. In particular, relations between the city and the organization of the scientific development of urban systems are gaining importance.
Additional file 1 of External applicability of SGLT2 inhibitor cardiovascular outcome trials to patients with type 2 diabetes and cardiovascular disease
Creators: name: Smidt, Lisanne C. A.
name: Visseren, Frank L. J.
name: de Ranitz-Greven, Wendela L.
name: Nathoe, Hendrik M.
name: Kappelle, L. Jaap
name: de Borst, Gert J.
name: de Valk, Harold W.
name: Westerink, Jan
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1: Table S1. Baseline characteristics UCC-SMART type 2 diabetes patients with cardiovascular history and SGLT2 inhibitor cardiovascular outcome trials. Table S2. Number of UCC-SMART patients ineligible per criterion. Table S3. Baseline characteristics trial eligible and trial ineligible UCC-SMART patients. Table S4. Hazard ratios for individual MACE components in trial eligible vs ineligible patients.
Additional file 1 of Depression and its associated factors: perceived stress, social support, substance use and related sociodemographic risk factors in medical school residents in Nairobi, Kenya
Creators: name: Shah, Sayed Shah Nur Hussein
name: Laving, Ahmed
name: Okech-Helu, Violet Caroline
name: Kumar, Manasi
Publisher: name: figshare
Year: 2021
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Sociodemographic questionnaire. The file contains the sociodemographic questionnaire that was used in our study in its entirety.
Additional file 2 of Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury
Creators: name: Jiao, Yang
name: Zhang, Ti
name: Zhang, Chengmi
name: Ji, Haiying
name: Tong, Xingyu
name: Xia, Ran
name: Wang, Wei
name: Ma, Zhengliang
name: Shi, Xueyin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Supplementary results
title: Blockchain Technology Adoption for Supply Chain Management in Austria
Creators: name: Gabriel, Hermann Jakob
Publisher: name: TU Wien
Year: 2023
Subjects: subject: Blockchain Technology
subject: Supply Chain Management
subject: Technology Adoption
subject: Inter-Organizational Systems

description: This master’s thesis presents a comprehensive study of blockchain technology adoption for supply chain management in Austria. The thesis includes three literature reviews: one on blockchain technology, another on its application tosupply chain management, and a third on blockchain adoption studies and theories.Based on the findings from the literature reviews, a new approach for studying blockchain adoption was developed. Our adoption framework is based on aprocessual approach that includes Neo-Institutional Theory and the Technology-Organization-Environment (TOE) framework. It was tested in a preliminary study consistsing of interviews with Austrian organizational managers.The development of this new framework was necessary due to the structure ofthe Austrian economy, which consists of a majority of small and medium-sizedenterprises (SMEs). As discovered during the literature review, existing literature on blockchain technology adoption for supply chain management does not adequately address the role of SMEs in this process. The main idea of our frameworkis to focus on the inter-organizational environment and use the supply chain asthe unit of analysis rather than the individual company, which allows for a better evaluation of the situation and expectations of organizations about the adoptionof blockchain technology for supply chain management.The findings of the study showed the importance of taking the structure of the supply chain into account when studying blockchain adoption in this context and therefore indicate the validity of the developed framework. Furthermore, the findings provide valuable insights into the current situation of the adoption process of blockchain technology for supply chain management in Austrian organizations.In addition, the findings suggest that future blockchain technology adoption studies for supply chain management should be separated based on different adoption scenarios and differentiate between developing and participating companies inthe blockchain solution. This approach will provide a more useful understanding of the factors that influence the adoption of blockchain technology in the supplychain management field. Finally, the results of this thesis indicate that, atthe current moment, it should be of high importance for Austrian policymakers to support those companies that might be facing a mandatory adoption of blockchain technology for supply chain management, demanded by other participants in their supply chain.
Inflation from the Higgs field false vacuum with hybrid potential
Creators: name: Masina, Isabella
name: Notari, Alessio
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We have recently suggested [1,2] that Inflation could have started in a local minimum of the Higgs potential at field values of about $10^{15}-10^{17}$ GeV, which exists for a narrow band of values of the top quark and Higgs masses and thus gives rise to a prediction on the Higgs mass to be in the range 123-129 GeV, together with a prediction on the the top mass and the cosmological tensor-to-scalar ratio $r$. Inflation can be achieved provided there is an additional degree of freedom which allows the transition to a radiation era. In [1] we had proposed such field to be a Brans-Dicke scalar. Here we present an alternative possibility with an additional subdominant scalar very weakly coupled to the Higgs, realizing an (inverted) hybrid Inflation scenario. Interestingly, we show that such model has an additional constraint $m_H<125.3 \pm 3_{th}$, where $3_{th}$ is the present theoretical uncertainty on the Standard Model RGEs. The tensor-to-scalar ratio has to be within the narrow range $10^{-4}\lesssim r<0.007$, and values of the scalar spectral index compatible with the observed range can be obtained. Moreover, if we impose the model to have subplanckian field excursion, this selects a narrower range $10^{-4} \lesssim r<0.001$ and an upper bound on the Higgs mass of about $m_H <124 \pm 3_{th}$.
description: v1: 9 pages, 3 figures; v2: 9 pages, 3 figures, improvements in the text, version matching the JCAP published one
Patient-Reported Outcome Measures to Inform Measurement-based Care for Youth Living with Mental Health Concerns: A mixed method study
Creators: name: Thapa Bajgain, Kalpana
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Youth
subject: Mental
subject: Patient Reported Outcome Measures
subject: Mental Health

description: Measurement-based care (MBC) describes the process of routinely using outcome measurement to guide treatment decisions supporting Patient-centered Care (PCC). Patient-reported Outcome Measures (PROMs) play a vital role in MBC supporting the delivery of PCC. Despite the evidence on the benefits of using PROMs in clinical care, some barriers hinder the selection of the PROMs, such as the different age groups for youth and poor consensus on which measurements are best practices and most appropriate for this population. This mixed-methods, multi-phased study addresses some of these gaps by focusing on identifying, selecting, and prioritizing the PROMs to be implemented in the clinical care of youth with depression and/or anxiety to inform the MBC program at the Summit Center. The first phase of this thesis work includes three stages: 1) a systematic review to identify, evaluate, and synthesize the global evidence on the use of PROMs in youth mental health clinical care 2) In the second stage, we create and combine a database of PROMs from different sources. In the third step, we selected the top 10 PROMs to prioritize in Phase 2. The selected top 10 PROMs were: Beck Depression Inventory (BDI), Child Behavioral Checklist (CBC), Child Health Questionnaire (CHQ), KIDSCREEN 10, Pediatric Quality of Life Inventory (PedsQL), Revised Children's Anxiety and Depression Scale (RCAD 25), Spence Children’s Anxiety Scale (SCAC), Screen for Child Anxiety Related Disorder (SCARED), Strength and Difficulties Questionnaires (SDQ), and The Young Person’s Core (YP-CORE). Then, in Phase 2, we conducted the Nominal Group Technique (NGT) with youth living with depression and anxiety and their family caregivers to prioritize these top 10 PROMs. The top PROMs ranked by youth were RCAD 25, BDI, YP-CORE, SCAS, SCARED, CBCL, PedsQl, SDQ, KIDSCREEN 10, and CHQ, while families/caregivers top-ranked RCAD 25, SCARED, YP-CORE, KIDSCREEN 10, SCAS, CBCL, PedsQl, SDQ, BDI, and CHQ. In summary, the findings of this study informed the MBC program at the Summit Center and presented an excellent opportunity to leverage the findings of this study to support the scale-up implementation of PROMs in the clinical care for youth living with mental health in Alberta.
The distribution of Dopamine Receptors in the Mesencephalic Locomotor Region and colocalization with inhibitory and excitatory cell types
Creators: name: Di Vito, Stephanie
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Mesencephalic Locomotor Region
subject: Dopamine Receptors
subject: RNAscope
subject: Neuroscience

description: The dopaminergic (DA) control of motor function has for many decades been thought to be indirect via substantia nigra pars compacta (SNc) projections to the striatum. DA interaction with dopamine D1 or D2 -receptor (D1R or D2R) expressing cells in the striatum leads to locomotion via disinhibition of Mesencephalic Locomotor region (MLR) neurons. The MLR is known to be a key centre for the control of locomotion. It comprises the cuneiform nucleus (CnF) and pedunculopontine nucleus (PPN). These regions are heterogeneous and show differential effects on locomotion following stimulation of either glutamatergic or GABAergic cells. The MLR receives predominantly inhibitory input from the basal ganglia. Recently, our lab discovered that a dopaminergic nucleus within the medial zona incerta (mZI); the A13, projects to the MLR. Direct dopaminergic projections that modulate locomotion, from the SNc to the MLR, have also been identified in lampreys and rats. This suggests at least two direct dopaminergic control pathways to the MLR that lie parallel to the canonical nigrostriatal DA pathway and modulate motor control. However, it is not well understood how dopamine receptors are distributed across cellular subtypes in the MLR. In this thesis I used adult C57BL/6 male and female mice to address this gap. RNAscope® was performed to determine the distribution of DA receptor mRNA on vGLUT2 and vGAT neurons within the PPN and CnF. Overall, D2+5R were the highest expressing subtypes of DARs, while D1,3, and 4R were sparsely expressed. There were no significant differences in D1-5R expression between the PPN and CnF. D5R cells showed colocalization with cells expressing vGLUT2 mRNA, while D2R had significant subpopulations of cells expressing both vGAT and vGLUT2 mRNA. My thesis suggests that DA modulation of MLR neurons are predominantly D2R mediated, and dopamine may play a role in opposing behaviours, due to D2R expression on glutamatergic and GABAergic cells. Further investigation is needed to determine the functional role of dopamine receptors in the MLR and upstream nuclei (A13, SNc, or both) contributing to dopaminergic modulation of the MLR.
Role of Mycobacterium tuberculosis protein tyrosine phosphatase A in the pathogenesis of tuberculosis
Creators: name: Wong, Dennis Dick-Hang
Publisher: name: University of British Columbia
Year: 2012

description: One of the main mechanisms by which the etiological agent of tuberculosis (TB), Mycobacterium tuberculosis (Mtb), survives in the host macrophage is by its capacity to arrest phagosome acidification and fusion with lysosomes. This Mtb feature is associated with phagosomal exclusion of the Vacuolar H⁺-ATPase (V-ATPase) proton pump, which normally drives luminal acidification of membranous organelles. Although this phenomenon has been known for 20 years, the mechanism by which Mtb blocks phagosome acidification remains obscure. Research on Mtb pathophysiology shows that a wide array of Mtb lipid and protein molecules contribute to maintaining the mycobacterial phagosome in an immature state. We have previously found that Mtb protein-tyrosine Phosphatase A (PtpA) is required for Mtb infection of human macrophages. PtpA is secreted into the macrophage cytosol to inactivate the human VPS33B, a component of the Class C VPS Complex that regulates endosomal membrane fusion. VPS33B dephosphorylation by PtpA results in the inhibition of phagosome-lysosome fusion. In this work, we demonstrated that, in addition to its phosphatase activity, PtpA is also capable of binding to subunit H of the macrophage V-ATPase complex, indicating that PtpA can directly disrupt phagosome acidification. Indeed, we found that a Mtb strain expressing a V-ATPase-binding defective mutant PtpA protein failed to inhibit phagosome acidification, and expression of wild-type PtpA protein in E. coli-infected macrophages is sufficient to block acidification. Furthermore, we showed that the Class C VPS complex associates with V-ATPase during phagosome maturation, identifying a novel role for V-ATPase in coordinating endocytic membrane fusion. PtpA interaction with host V-ATPase is required for the previously reported dephosphorylation of VPS33B and subsequent exclusion of V-ATPase from the phagosome during Mtb infection. Taken together, these findings reveal, for the first time, the long-sought mechanism behind the lack of acidification in the mycobacterial phagosome. Interestingly, we found that PtpA is also a substrate for the newly identified Mtb protein tyrosine kinase PtkA, which is encoded within a shared operon with PtpA, indicating a regulatory control of PtpA during Mtb infection. Understanding the pathophysiological importance of PtpA in Mtb infection might contribute to the development of novel antitubercular therapeutics.
The competition between confinement and ram pressure and its implications for galaxies in groups and clusters
Creators: name: Bahe, Yannick M.
name: McCarthy, Ian G.
name: Crain, Robert A.
name: Theuns, Tom
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Ram pressure stripping of the hot gas that surrounds normal galaxies as they fall into groups and clusters (also referred to as `strangulation' or `starvation') is generally thought to shut down star formation on a time scale of a few Gyr. However, it has recently been suggested, on the basis of X-ray-optical scaling relations of galaxies in the field and the group/cluster environment, that confinement pressure by the intra-cluster medium can actually lead to an increase in the mass of hot gas surrounding these galaxies. We investigate the competition between pressure confinement and ram pressure stripping for satellite galaxies in orbit about galaxy groups and clusters using simple analytic models and detailed cosmological hydrodynamic simulations. It is found that, independent of host mass, ram pressure is generally dominant over confinement pressure --- only ~16 % of galaxies find themselves in the reverse situation. Furthermore, these galaxies have, on average, less hot gas than ram-pressure dominated ones, contrary to simple expectations. This is explained by the fact that the small number of galaxies which are confinement dominated are typically at first or second apocentre and have therefore already been maximally affected by ram pressure stripping around first pericentre. Our results are shown to be insensitive to host halo mass; we argue that the same is true for uncertain sub-grid processes, such as feedback.
description: 9 pages, 6 figures; accepted to MNRAS. Minor changes to match published version
Additional file 2 of Depression and its associated factors: perceived stress, social support, substance use and related sociodemographic risk factors in medical school residents in Nairobi, Kenya
Creators: name: Shah, Sayed Shah Nur Hussein
name: Laving, Ahmed
name: Okech-Helu, Violet Caroline
name: Kumar, Manasi
Publisher: name: figshare
Year: 2021
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Supplementary Table 1. Post Hoc ANOVA of Significant Variables.
Augmented QArt: Interactive Art Recreation by Mobile Augmented Reality
Creators: name: Booshehrian, Mahnaz
Publisher: name: Science
Year: 2024
Subjects: subject: Design and Decorative Arts
subject: Computer Science

description: The integration of technology into art galleries and museums has opened new avenues for enhancing visitors' experiences and addressing challenges related to accessibility, interactivity, and artistic attraction. Inspired by Picasso’s Cubism paintings and Augmented Reality technology, this thesis explores the design of aesthetically detectable codes, known as QArt codes, to enhance accessibility and visual appeal and to enrich traditional art experiences in settings where space and time are limited. The project aims to answer questions about how technology can be leveraged to enhance artistic environments, offer interactive access to artwork information, and seamlessly blend the actual and virtual realms. Through the implementation of QArt codes, people can easily access and explore various artworks, including Picasso's Harlequin paintings, while saving time and money. This approach offers visitors a chance to learn about different aspects of the artwork, such as style, techniques, and historical context. Interacting with QArt codes provides an engaging and memorable experience, leaving a lasting impression on visitors. A qualitative user study conducted at the end of the project revealed that QArt codes can provide a nuanced understanding of Picasso's artistic range and insight into the Cubism style through multiple dimensions. Overall, QArt codes are an effective and captivating way to share artworks with the world.
Neutrophil- and B cell-mediated host defense against viral and fungal respiratory infections
Creators: name: Sarden, Nicole
Publisher: name: Cumming School of Medicine
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Infections of the lung continue to be a worldwide annual problem affecting millions of people. Fighting acute respiratory infections requires rapid and collaborative responses involving diverse immune cells. An interesting and unexplained clinical problem that sparked this thesis was the clinical observation that influenza A, a common respiratory virus, increases susceptibility to secondary infections with environmental fungi such as Aspergillus fumigatus (Af). By establishing a mouse model of viral-fungal co-infection and using clinical human samples, I discovered an essential collaboration between an underappreciated innate B lymphocyte, called B1a, which produced natural antibodies against Af, which tagged the fungi for elimination by neutrophils. Following influenza A infections, B1a cells died of apoptosis leading to diminished natural anti-Af antibodies and negating the ability of neutrophils to target and eliminate Af. Disruption of this axis explained susceptibility in viral- and steroid-associated infections. Delving deeper into the requirements of immune cell resistance to influenza and Af as individual infections, I discovered unique roles for neutrophils during influenza and innate B cells in aspergillosis. While there is ample research investigating neutrophils and their roles during infections with extracellular pathogens, it remained unclear how the neutrophil pool is affected following viral infections and subsequent functional outcomes. Additionally, it has been recently proposed that an interferon-responsive neutrophil state with unknown functions emerges following viral infections. In isolated viral infection, I found neutrophils adapt to an anti-viral phenotype which is spatially regulated, requires type I interferon licensing and sympathetic drive. On the other hand, using a genetically engineered mouse, we studied the specific roles of innate B1a cells during Aspergillus infection and found that this rare antibody producing cells was essential for host resistance against isolated Af infection. Moreover, I discovered key molecular requirements of the B1a cells that allow them to traffic and recruit properly in the lung, and I discovered that these cells can be amplified to improve host defense against Af. Altogether, this body of work uncovers neutrophils’ effects following isolated viral infection and during co-infection and demonstrates the tight interconnectedness between neutrophils and B lymphocytes which are critical for anti-fungal immunity.
Unity of elementary particles and forces for the third family
Creators: name: Chakdar, Shreyashi
name: Li, Tianjun
name: Nandi, S.
name: Rai, Santosh Kumar
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a non-supersymmetric SU(5) model in which only the third family of fermions are unified. The model remedies the non-unification of the three Standard Model couplings in non-supersymmetric SU(5). It also provides a mechanism for baryon number violation which is needed for the baryon asymmetry of the Universe and is not present in the Standard Model. Current experimental constraints on the leptoquark gauge bosons, mediating such baryon and lepton violating interactions in our model, allow their masses to be at the TeV scale. These can be searched for as a (bτ) or (tt) resonance at the Large Hadron Collider as predicted in our model.
description: Title changed, some changes in text and figures. Published in Phys. Lett. B
Signals of exomoons in averaged light curves of exoplanets
Creators: name: Simon, A. E.
name: Szabó, Gy. M.
name: Kiss, L. L.
name: Szatmáry, K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The increasing number of transiting exoplanets sparked a significant interest in discovering their moons. Most of the methods in the literature utilize timing analysis of the raw light curves. Here we propose a new approach for the direct detection of a moon in the transit light curves via the so called Scatter Peak. The essence of the method is the valuation of the local scatter in the folded light curves of many transits. We test the ability of this method with different simulations: Kepler "short cadence", Kepler "long cadence", ground-based millimagnitude photometry with 3-min cadence, and the expected data quality of the planned ESA mission of PLATO. The method requires ~100 transit observations, therefore applicable for moons of 10-20 day period planets, assuming 3-4-5 year long observing campaigns with space observatories. The success rate for finding a 1 R_Earth moon around a 1 R_Jupiter exoplanet turned out to be quite promising even for the simulated ground-based observations, while the detection limit of the expected PLATO data is around 0.4 R_Earth. We give practical suggestions for observations and data reduction to improve the chance of such a detection: (i) transit observations must include out-of-transit phases before and after a transit, spanning at least the same duration as the transit itself; (ii) any trend filtering must be done in such a way that the preceding and following out-of-transit phases remain unaffected.
description: 9 pages, 5 figures, accepted for publication in MNRAS. Typos corrected
Additional file 1 of Are there socio-demographic differences in salt behaviours and fruit and vegetable consumption in Australian adults? A nationally representative cross-sectional survey
Creators: name: Rosewarne, Emalie
name: Santos, Joseph Alvin
name: Hoek, Annet
name: Grimes, Carley
name: Nowson, Caryl
name: Webster, Jacqui
name: Bolton, Kristy A.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: Plant Biology

description: Additional file 1.
Transport equations for the inflationary spectral index
Creators: name: Dias, Mafalda
name: Seery, David
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a simple and efficient method to compute the superhorizon evolution of the spectral index in multi-field inflationary models, using transport equation techniques. We illustrate the evolution of n_s with time for various interesting potentials.
description: 6 pages; minor changes to match published version
Higher cohomology for Anosov actions on certain homogeneous spaces
Creators: name: Ramirez, Felipe A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We study the smooth untwisted cohomology with real coefficients for the action on [SL(2, R) \times \cdot \cdot \cdot \times SL(2, R)]/Γ by the subgroup of diagonal matrices, where Γ is an irreducible lattice. In the top degree, we show that the obstructions to solving the coboundary equation come from distributions that are invariant under the action. In intermediate degrees, we show that the cohomology trivializes. It has been conjectured by A. and S. Katok that, for a standard partially hyperbolic R^d- or Z^d-action, the obstructions to solving the top-degree coboundary equation are given by periodic orbits, in analogy to Livsic's theorem for Anosov flows, and that the intermediate cohomology trivializes, as it is known to do in the first degree, by work of Katok and Spatzier. Katok and Katok proved their conjecture for abelian groups of toral automorphisms. For diagonal subgroup actions on SL(2, R)^d /Γ, our results verify the "intermediate cohomology" part of the conjecture, and are a step in the direction of the "top-degree cohomology" part.
description: 33 pages; added one-paragraph subsection 1.3; made minor typographical adjustments; re-wrote Lemmas 3.3 and 4.1, resulting in some changed subscripts and superscripts corresponding to Sobolev orders
Parallelization of Bayesian Phylogenetics to Greatly Improve Run Times
Creators: name: Yang, David
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Markov Chain Monte Carlo
subject: SARS-CoV-2
subject: Simulation
subject: Bayesian
subject: Phylogenetic analysis
subject: Parallelization
subject: Biostatistics
subject: Statistics
subject: FOS: Mathematics
subject: Epidemiology
subject: Bioinformatics
subject: FOS: Computer and information sciences

description: Phylogenetic analyses are invaluable to understanding the transmission of viruses, especially during disease outbreaks. In particular, Bayesian phylogenetics has great potential in modeling viral transmission due to the numerous phylogenetic models that can be incorporated. Currently, the availability of user-friendly software and accessibility to sequence data makes phylogenetic analyses easy to perform. However, to date, Bayesian phylogenetic analyses are still limited by long computational run-times which are especially unfavorable during ongoing and evolving disease outbreaks that demand real-time phylogeny results. Current optimization methods of Bayesian phylogenetic analysis mainly focus on iteration-level parallelization and mostly overlook the potential of larger-scale parallelization approaches. In this thesis, we provide an in-depth overview of topics including phylogenetic analysis, relevant biological information, and phylogenetic analysis optimization methods. We also proposed a novel parallelized Markov Chain Monte Carlo method that greatly improved Bayesian phylogenetic run times and integrated the approach into a data pipeline to allow for the direct analysis of viral samples. We demonstrated the validity of our methods by performing phylogenetic analyses on two sets of HIV simulation data and one set of real-world SARS-CoV-2 data. Our results suggested that the parallelization of MCMC in Bayesian phylogenetic analyses drastically reduces run times by 29-fold without causing significant deviations in parameter estimates and predicted phylogenetic trees.
Protocolo de Revisão Integrativa
Creators: name: Costa, Murilo
name: Nascimento, Marcia Helena
name: Mendes, Clarissa Porfírio
name: Gomes, Rodrigo
name: Lima, Fernando Conceição de
name: Guimarães, Reinaldo de Souza
name: Sagíca, Taís dos Passos
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420599
subject: Nursing not elsewhere classified
classificationCode: 420505
subject: Nursing workforce

description: Trata-se de um estudo exploratório-descritivo do tipo revisão integrativa da literatura, a qual teve como questão norteadora “Quais as evidências acerca das inadequações e erros nos registros do balanço hídrico no contexto hospitalar?”. A busca da literatura foi realizada de junho a julho de 2022, por um autor, por meio das seguintes bases de dados: PubMed da National Library of Medicine, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Scopus da ELSEVIER, Web of Science da Thomson Reuters Scientific, Biblioteca Virtual em Saúde (BVS) agregando as bases de dados como Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed Central® (PMC), o repositório de trabalhos científicos Scientific Electronic Library Online (SciELO). Foi identificado 160 artigos, os quais passaram pelos filtros dos critérios de inclusão e exclusão, chegando ao total de 6 artigos, sendo representado pelo fluxograma do preferred Reporting Items for Systematic Reviews and Meta-Analyse (PRISMA). Ao fim da pesquisa será elaborado um artigo científico que contará com o percurso metodológico e os resultados obtidos da análise dos estudos desta RI, a qual será apresentado de maneira descritiva.
Design of a self-paced brain-computer interface based on mental tasks
Creators: name: Faradji, Farhad
Publisher: name: University of British Columbia
Year: 2012

description: People with very severe motor-disabilities have to accept a much-reduced quality of life. Unfortunately, these people cannot use assistive devices as present devices require motor activities. Brain-computer interfaces (BCIs) provide an alternative means of communication between the brain and assistive devices. There are two types of BCIs, synchronous and self-paced. Self-paced BCIs are more practical as they can be used at any time. The vast majority of existing self-paced BCIs are activated by real, attempted, or imagined movements. Few are activated by mental tasks. The high false positive rates (FPRs) of existing self-paced BCIs render them impractical. There are no self-paced BCIs based on motor movements that have low FPRs. However, self-paced BCIs with low FPRs based on mental tasks have been proposed. Designing a self-paced mental task-based BCI with a zero or near zero FPR and a reasonable true positive rate (TPR) is the goal of this thesis. We investigated the feasibility of having a self-paced mental task-based BCI with a zero or near zero FPR. The EEG signals from 6 electrodes of 4 subjects performing 4 mental tasks are used. Features were extracted using autoregressive modeling. Different classifiers were tested. The results were promising in that zero FPRs were obtained. The data used, however, had not been collected in a self-paced paradigm. We then collected the EEG signals from 29 channels of 4 subjects performing 4 mental tasks in a self-paced paradigm. We evaluated the performance of our BCI using this dataset. It yielded an average TPR of 67.26% and zero FPR. To make the system practical, we decrease the number of channels from 29 to 7 and 5, using 2 approaches that yield local optimal results. The average TPR is sufficiently high (54.60% and 59.98% for systems with 5 and 7 channels) while the FPRs remain zero. We also study the effects on the performance, as the segment length is varied. For the 7-channel BCIs, the optimum length is between 1 and 2.5 sec. The average TPR is improved to 63.47%. The FPRs are zero. We also show that our BCIs are robust to artifacts.
Tax Policy Trends: Canadian Policy Makers Respond to U.S. Tax Overhaul
Creators: name: Bazel, Philip
name: Mintz, Jack
Publisher: name: The School of Public Policy Publications
Year: 2019

description: Following the 2017 overhaul of the U.S. corporate and personal tax system, 2018 has seen much discussion regarding Canada’s diminished tax advantage and its attractiveness as an investment destination in comparison to the U.S. In the November 21st 2018 Economic Update, the federal government’s response was finally unveiled. The central policy included a generous temporary accelerated capital cost allowance. This strategy largely follows a plan of action championed by the Canadian business community and emulates features of the U.S. corporate tax reform. However, as we point out below, tinkering with depreciation schedules distorts further the corporate tax system and fails to deal with other competitive issues that can only be addressed by changes to the statutory corporate income tax rates.
description: The School of Public Policy Publications, Vol 12 (2019)
Leptacinus harbinensis BORDONI 2000
Creators: name: Bordoni, A.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Leptacinus
Leptacinus harbinensis

description: Leptacinus harbinensis BORDONI 2000
M a t e r i a l s t u d i e d: Aershan National Forest Park, Neimengu, (Inner Mongolia), Li & Huang 19.VII.2004, 1 ex. (SNUC); Wulinshan, Miyun coun., Bejing city, 750-850 m, Shen & Tang 8-9.VII.2006, 2 exx. (SNUC).
G e o g r a p h i c a l d i s t r i b u t i o n: The species was known from Harbin (Heilunggjiang), Gansu (BORDONI 2004) and Korea (BORDONI 2003f). This record show that in China this species live in the north-eastern regions. New record for Inner Mongolia.
description: Published as part of Bordoni, A., 2013, New data on the Xantholinini from China. 24. New genus, new species and new records of the Shanghai Normal University collection (Coleoptera, Staphylinidae) 244 ° contribution to the knowledge of the Staphylinidae, pp. 1745-1797 in Linzer biologische Beiträge 45 (2) on pages 1757-1758, DOI: 10.5281/zenodo.10273196
Exploring Hemodialysis Nurses’ Perceptions on Kidney Replacement Therapy Modality Education: A Framework Analysis
Creators: name: Jaibeeh Barah, Elke Etane
Publisher: name: Graduate Studies
Year: 2024
Subjects: subject: Kidney replacement therapy
subject: Modality education
subject: In-center hemodialysis
subject: Nurses
subject: Nursing
subject: FOS: Health sciences

description: Many people with end-stage kidney disease (ESKD) start and remain on in-centre hemodialysis (ICHD) treatment despite evidence of improved health and system outcomes when they choose a kidney replacement therapy (KRT) modality optimal to their lifestyle such as home dialysis. To make an informed modality decision patients must receive frequent, high quality modality education. This education is inconsistent in the ICHD setting where patients spend the most time with nurses while receiving hemodialysis treatments. The aim of this study was to examine ICHD nurses’ perceptions around KRT modality education for patients receiving ICHD using the COM-B model of behaviour change. To achieve this aim, I utilized the framework analysis (FA) method applying the COM-B model as a theoretical framework to analyze the data. The results demonstrated that ICHD nurses reported some impediments to providing modality education such as knowledge deficits, lack of experience or exposure to other dialysis modalities and lack of resources to support modality education practices. ICHD nurses reported some factors that enhanced modality education, including strong nurse-patient therapeutic relationships and previous experience in other dialysis modalities. I proposed some practice and educational recommendations geared toward targeted education of ICHD nurses, providing structure and appropriate resources to support KRT modality education practice in this setting. Keywords: Modality education, in-center hemodialysis, nurses, kidney replacement therapy
Strong coupling superconductivity, pseudogap and Mott transition
Creators: name: Sordi, G.
name: Sémon, P.
name: Haule, K.
name: Tremblay, A. -M. S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: An intricate interplay between superconductivity, pseudogap and Mott transition, either bandwidth driven or doping driven, occurs in materials. Layered organic conductors and cuprates offer two prime examples. We provide a unified perspective of this interplay in the two-dimensional Hubbard model within cellular dynamical mean-field theory on a $2\times 2$ plaquette and using the continuous-time quantum Monte Carlo method as impurity solver. Both at half filling and at finite doping, the metallic normal state close to the Mott insulator is unstable to d-wave superconductivity. Superconductivity can destroy the first-order transition that separates the pseudogap phase from the overdoped metal, yet that normal state transition leaves its marks on the dynamic properties of the superconducting phase. For example, as a function of doping one finds a rapid change in the particle-hole asymmetry of the superconducting density of states. In the doped Mott insulator, the dynamical mean-field superconducting transition temperature $T_c^d$ does not scale with the order parameter when there is a normal-state pseudogap. $T_c^d$ corresponds to the local pair formation temperature observed in tunneling experiments and is distinct from the pseudogap temperature.
description: 6 pages, 4 figures; published version