cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mass of cosmological perturbations in the hybrid and dressed metric formalisms of Loop Quantum Cosmology for the Starobinsky and exponential potentials
Creators: name: Iteanu, Simon
name: Marugán, Guillermo A. Mena
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The hybrid and the dressed metric formalisms for the study of primordial perturbations in Loop Quantum Cosmology lead to dynamical equations for the modes of these perturbations that are of a generalized harmonic-oscillator type, with a mass that depends on the background but is the same for all modes. For quantum background states that are peaked on trajectories of the effective description of Loop Quantum Cosmology, the main difference between the two considered formalisms is found in the expression of this mass. The value of the mass at the bounce is especially important, since it is only in a short interval around this event that the quantum geometry effects on the perturbations are relevant. In a previous article, the properties of this mass were discussed for an inflaton potential of quadratic form, or with similar characteristics. In the present work, we extend this study to other interesting potentials in cosmology, namely the Starobinsky and the exponential potentials. We prove that there exists a finite interval of values of the potential (which includes the zero but typically goes beyond the sector of kinetically dominated inflaton energy density) for which the hybrid mass is positive at the bounce whereas the dressed metric mass is negative.
description: 13 pages
Effects of Biases in Domain Wall Network Evolution
Creators: name: Correia, J. R. C. C. C.
name: Leite, I. S. C. R.
name: Martins, C. J. A. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the evolution of various types of biased domain wall networks in the early universe. We carry out larger numerical simulations than currently available in the literature and provide a more detailed study of the decay of these networks, in particular by explicitly measuring velocities in the simulations. We also use the larger dynamic range of our simulations to test previously suggested decay laws for these networks, including an ad-hoc phenomenological fit to earlier simulations and a decay law obtained by Hindmarsh through analytic arguments. We find the latter to be in good agreement with simulations in the case of a biased potential, but not in the case of biased initial conditions.
description: 9 pages
Immunohistochemical analysis of C/EBPα in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590
Creators: name: Johnson, David H.
name: Tenen, Daniel G.
name: Feins, Richard H.
name: Halmos, Balazs
name: Costa, Daniel B.
name: Li, Sigui
name: Kocher, Olivier
name: Keller, Steven M.
name: Schiller, Joan H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: We sought to determine the association of C/EBPα expression status with clinical, pathologic and molecular characteristics, as well as outcomes, in non-small-cell lung cancer (NSCLC). This is the first comprehensive study of this transcription factor in patients with NSCLC.
HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study
Creators: name: Schroeder, Jane C.
name: Folsom, Aaron R.
name: Coresh, Josef
name: Kucharska-Newton, Anna M.
name: McNeill, Ann Marie
name: Rosamond, Wayne D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: This study examined prospectively the association of baseline plasma HDL-cholesterol levels with incidence of lung cancer in 14, 547 members of the Atherosclerosis Risk in Communities (ARIC) cohort. There were 259 cases of incident lung cancer identified during follow-up from 1987 through 2000. Results of this study indicated a relatively weak inverse association of HDL-cholesterol with lung cancer that was dependent on smoking status. The hazard ratio of lung cancer incidence in relation to low HDL-cholesterol, adjusted for race, gender, exercise, alcohol consumption, body mass index, triglycerides, age, and cigarette pack-years of smoking, was 1.45 (95% confidence interval 1.10, 1.92). This association was observed among former smokers (hazard ratio: 1.77, 95% confidence interval 1.05, 2.97), but not current smokers. The number of cases among never smokers in this study was too small (n=13) for meaningful interpretation of effect estimates. Excluding cases occurring within five years of baseline did not appreciably change the point estimates, suggesting lack of reverse causality. The modest association of low plasma HDL-cholesterol with greater incident lung cancer observed in this study is in agreement with existing case-control studies.
A phase I trial of sorafenib combined with cisplatin/etoposide or carboplatin/pemetrexed in refractory solid tumor patients
Creators: name: Kim, William Y.
name: Walko, Christine M.
name: Hayes, D. Neil
name: Dhruva, Nirav S.
name: Bernard, Stephen
name: Chiu, Michael
name: Stinchcombe, Thomas E.
name: Davies, Janine M.
name: Keller, Kimberly
name: Dees, E. Claire
name: Ivanova, Anastasia
name: Hilbun, Layla R.
name: Socinski, Mark A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Sorafenib has demonstrated single agent activity in non-small cell (NSCLC) and small cell lung cancer (SCLC). Carboplatin/pemetrexed (CbP) and cisplatin/etoposide (PE) are commonly used in the treatment of these diseases.
Activity Detection in Distributed MIMO: Distributed AMP via Likelihood Ratio Fusion
Creators: name: Bai, Jianan
name: Larsson, Erik G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We develop a new algorithm for activity detection for grant-free multiple access in distributed multiple-input multiple-output (MIMO). The algorithm is a distributed version of the approximate message passing (AMP) based on a soft combination of likelihood ratios computed independently at multiple access points. The underpinning theoretical basis of our algorithm is a new observation that we made about the state evolution in the AMP. Specifically, with a minimum mean-square error denoiser, the state maintains a block-diagonal structure whenever the covariance matrices of the signals have such a structure. We show by numerical examples that the algorithm outperforms competing schemes from the literature.
description: 5 pages, 2 figures. This paper has been accepted for publication in IEEE Wireless Communications Letters. Code available at https://github.com/jiananbai/distributed-AMP
Revisiting Piggyback Prototyping: Examining Benefits and Tradeoffs in Extending Existing Social Computing Systems
Creators: name: Epstein, Daniel A.
name: Liu, Fannie
name: Monroy-Hernández, Andrés
name: Wang, Dennis
Publisher: name: arXiv
Year: 2022
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: H.5.3

description: The CSCW community has a history of designing, implementing, and evaluating novel social interactions in technology, but the process requires significant technical effort for uncertain value. We discuss the opportunities and applications of "piggyback prototyping", building and evaluating new ideas for social computing on top of existing ones, expanding on its potential to contribute design recommendations. Drawing on about 50 papers which use the method, we critically examine the intellectual and technical benefits it provides, such as ecological validity and leveraging well-tested features, as well as research-product and ethical tensions it imposes, such as limits to customization and violation of participant privacy. We discuss considerations for future researchers deciding whether to use piggyback prototyping and point to new research agendas which can reduce the burden of implementing the method.
description: To appear at the 25th ACM Conference On Computer-Supported Cooperative Work And Social Computing (CSCW '22)
Challenges scoring radiation pneumonitis in patients irradiated for lung cancer
Creators: name: Rosenman, Julian
name: Yirmibesoglu, Eda
name: Xie, Liyi
name: Fayda, Merdan
name: Marks, Lawrence B.
name: Higginson, Daniel S.
name: Halle, Jan
name: Rivera, M. Patricia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To quantify uncertainties in scoring radiation pneumonitis.
Radiative decay effects influence the local electromagnetic response of the monolayer graphene with surface corrugations in terahertz range
Creators: name: Firsov, Yu. A.
name: Firsova, N. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We continue the study of surface corrugations influence on the monolayer graphene local electromagnetic response in terahertz range we started earlier. The effects of radiative decay, double-valley structure of charge carriers spectrum in graphene and the breathing surface curvature form induced synthetic electric fields are taken into account. To fulfill this program the generalized nonlinear self-consistent equation is obtained. In case of weak external alternating electric field for the obtained equation in linear approximation on the external electric field the exact solution is found. It shows that in this case we get local dephasing in induced current paths depending on the surface form . This theoretical result qualitatively explains the corresponding experiments with local current patterns in graphene without using fully quantum approach which is necessary for theoretical description of such phenomenon in graphene nanoribbons. Besides the formulae obtained in the present paper could become the basis of the new method of the imaging of surface corrugations form for given picture of local current paths. The obtained results allow to study mechanical behavior of materials at nanoscale deviates from macroscoping established concepts and this is of particular importance for graphene.
Experimental Investigation on the Properties of Recycled Concrete Using Hybrid Fibers
Creators: name: Khoso, Salim
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400504
subject: Construction engineering
classificationCode: 400505
subject: Construction materials
classificationCode: 400510
subject: Structural engineering

description: Due to the inherent property of concrete being very weak in tension, efforts have been made to overcome this deficiency by adding various type of fibers like carbon fiber reinforced polymer (CFRP), glass fiber reinforced polymer (GFRP), polypropylene fiber (PPF) and stainlesssteel fiber (SSF) smeared into the concrete mix. The present study involves experimental investigation on the use of GFRP, CFRP and SSF fibers alone or as combination to improve the mechanical properties of concrete. Furthermore, concrete cylinders were cast and tested for compression and tension using 10% fly ash as cement replacement in all specimens. Besides fiber material types, fiber reinforcement ratios of 1% and 1.5% were tested to investigate the mechanical properties of concrete. In all concrete cylinder tests, the fiber reinforcement ratio of 1% had a significant contribution in increasing the tensile strength as oppose to compressive strength. As a result, the tensile and compressive strengths were increased by 26% and 11%, respectively as compared to the control specimen. Increasing the fiber reinforcement ratio from 1% to 1.5%, resulted in diminishing the mechanical properties of concrete. However, reduction in concrete compressive strength was more prominent than the tensile strength. Furthermore, it was observed that, the crack propagation was decreased with the increase of fiber content when compared to the control specimen.
Factors associated with adherence to chemotherapy guidelines in patients with non-small cell lung cancer
Creators: name: Salloum, Ramzi G.
name: Lafata, Jennifer Elston
name: Smith, Thomas J.
name: Jensen, Gail A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Evidence-based guidelines recommend chemotherapy for medically fit patients with stage II–IV non-small cell lung cancer (NSCLC). Adherence to chemotherapy guidelines has rarely been studied among large populations, mainly because performance status (PS), a key component in assessing chemotherapy appropriateness, is missing from claims-based datasets. Among a large cohort of patients with known PS, we describe first line chemotherapy use relative to guideline recommendations and identify patient factors associated with guideline concordant use.
Core-shell enhanced single particle model for lithium iron phosphate batteries: model formulation and analysis of numerical solutions
Creators: name: Pozzato, Gabriele
name: Takahashi, Aki
name: Li, Xueyan
name: Lee, Donghoon
name: Ko, Johan
name: Onori, Simona
Publisher: name: arXiv
Year: 2022
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, a core-shell enhanced single particle model for iron-phosphate battery cells is formulated, implemented, and verified. Starting from the description of the positive and negative electrodes charge and mass transport dynamics, the positive electrode intercalation and deintercalation phenomena and associated phase transitions are described with the core-shell modeling paradigm. Assuming two phases are formed in the positive electrode, one rich and one poor in lithium, a core-shrinking problem is formulated and the phase transition is modeled through a shell phase that covers the core one. A careful discretization of the coupled partial differential equations is proposed and used to convert the model into a system of ordinary differential equations. To ensure robust and accurate numerical solutions of the governing equations, a sensitivity analysis of numerical solutions is performed and the best setting, in terms of solver tolerances, solid phase concentration discretization points, and input current sampling time, is determined in a newly developed probabilistic framework. Finally, unknown model parameters are identified at different C-rate scenarios and the model is verified against experimental data.
Survival among non-small cell lung cancer patients with poor performance status after first line chemotherapy
Creators: name: Lafata, Jennifer Elston
name: Salloum, Ramzi G.
name: Smith, Thomas J.
name: Jensen, Gail A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Performance status (PS) is a commonly used factor in determining the appropriateness for chemotherapy of patients with non-small cell lung cancer (NSCLC). The prevalence of poor PS and impact of chemotherapy on survival among NSCLC patients has not been studied in community populations.
“Le Navi romane si possono vedere anche in tre”. Il Museo di Nemi nella sequenza del film L’assassino di Elio Petri (1961)
Creators: name: Grippa, Ilaria;Toson, Christian
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: L assassino
Italian Cinema
Elio Petri
Nemi ships Museum

description: The subject of this contribution is a scene from the film L’assassino, Elio Petri’s debut film released in April 1961. The analysis is proposed as a useful tool for investigating the Museo delle Navi di Nemi, in particular its setting in the post World War II period, analysing how the museum appears in the film sequence.
The Geometry of the Cholesteric Phase
Creators: name: Beller, Daniel A.
name: Machon, Thomas
name: Čopar, Simon
name: Sussman, Daniel M.
name: Alexander, Gareth P.
name: Kamien, Randall D.
name: Mosna, Ricardo A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We propose a construction of a cholesteric pitch axis for an arbitrary nematic director field as an eigenvalue problem. Our definition leads to a Frenet-Serret description of an orthonormal triad determined by this axis, the director, and the mutually perpendicular direction. With this tool we are able to compare defect structures in cholesterics, biaxial nematics, and smectics. Though they all have similar ground state manifolds, the defect structures are different and cannot be, in general, translated from one phase to the other.
description: 5 pages, the full catastrophe
Support service use and interest in support services among lung cancer patients
Creators: name: Champion, Victoria L.
name: Fakiris, Achilles J.
name: Hanna, Nasser
name: Kesler, Kenneth A.
name: Einhorn, Lawrence H.
name: Jalal, Shadia I.
name: Mosher, Catherine E.
name: Birdas, Thomas J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: This study examined support service use and interest in support services among lung cancer patients (N = 165) at two comprehensive medical centers in the midwestern United States.
A single-arm phase II trial of pazopanib in patients with advanced non-small cell lung cancer with non-squamous histology with disease progression on bevacizumab containing therapy
Creators: name: Villaruz, Liza C.
name: Weiss, Jared M.
name: Grilley-Olson, Juneko
name: Ivanova, Anastasia
name: Stinchcombe, Thomas E.
name: Dhruva, Nirav
name: Socinski, Mark A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Platinum-based chemotherapy with bevacizumab is a standard therapy for patients with stage IIIB/IV non-small cell lung cancer (NSCLC) with non-squamous (NS) histology. Mechanisms of resistance to bevacizumab include increased VEGF signaling or activation of VEGF receptors. Pazopanib is a multi-targeted VEGF receptor tyrosine kinase with single agent activity in NSCLC.
Restricted phase space thermodynamics for black holes in higher dimensions and higher curvature gravities
Creators: name: Kong, Xiangqing
name: Wang, Tao
name: Gao, Zeyuan
name: Zhao, Liu
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The recently proposed restricted phase space thermodynamics is shown to be applicable to a large class of higher dimensional higher curvature gravity models coupled to Maxwell field, which are known as black hole scan models and are labeled by the spacetime dimension $d$ and the highest order $k$ of the Lanczos-Lovelock densities appearing in the action. Three typical example cases with $(d,k)=(5,1), (5,2)$ and $(6,2)$ are chosen as example cases and studied in some detail. These cases are representatives of Einstein-Hilbert, Chern-Simons and Born-Infield like gravity models. Our study indicates that the Einstein-Hilbert and Born-Infield like gravity models have similar thermodynamic behaviors, e.g. the existence of isocharge $T-S$ phase transitions with the same critical exponents, the existence of isovoltage $T-S$ transitions and the Hawking-Page like transitions, and the similar high temperature asymptotic behaviors for the isocharge heat capacities, etc. However, the Chern-Simons like $(5,2)$-model behaves quite differently. Neither isocharge nor isovoltage $T-S$ transitions could occur and no Hawking-Page like transition is allowed. This seems to indicate that the Einstein-Hilbert and Born-Infield like models belong to the same universality class while the Chern-Simons like models do not.
description: 29 pages. v2: typo in the title corrected
title: Η αποτίμηση της εξέλιξης του θεσμού της Αποκεντρωμένης Διοίκησης, με γνώμονα τις συστάσεις της μελέτης ΟΟΣΑ για την ελληνική Δημόσια Διοίκηση (2011)
title: Assessment of the Decentralized Administrations’ evolution according to the recommendations of the OECD review of the Greek central administration (2011)
titleType: AlternativeTitle
Creators: name: Σκλήφα, Θεοδώρα
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Δημόσια Διοίκηση--Ελλάδα
subject: Περιφερειακός προγραμματισμός--Ελλάδα
subject: Αποκεντρωμένη Διοίκηση
subject: «Πρόγραμμα Καλλικράτης»
subject: Μελέτη ΟΟΣΑ για την ελληνική Δημόσια Διοίκηση (2011)
subject: αποκέντρωση
subject: συγκεντρωτισμός

description: Η παρούσα εργασία πραγματεύεται την εξέλιξη του θεσμού της Αποκεντρωμένης Διοίκησης, του περιφερειακού κρατικού οργάνου, που συστάθηκε για πρώτη φορά το 2010 με τη ψήφιση του «Προγράμματος Καλλικράτης» (Ν.3852/2010) και διαδέχθηκε της κρατικές Περιφέρειες. Οι αλλαγές που έχει υποστεί ο θεσμός το χρονικό διάστημα 2011-2022 εξετάζονται υπό το πρίσμα των γενικών συστάσεων της μελέτης του ΟΟΣΑ για την ελληνική Δημόσια Διοίκηση (2011) και επιχειρείται να διαπιστωθεί αν οι αλλαγές αυτές βελτιστοποιούν το θεσμό της Αποκεντρωμένης Διοίκησης ή αν υπηρετούνται άλλοι σκοποί. Μέσα από την αναζήτηση και την επισκόπηση πρωτογενών πηγών και της υφιστάμενης σχετικής βιβλιογραφίας και αρθρογραφίας, εξετάζεται ουσιαστικά σε ποιο βαθμό οι αλλαγές που έχουν συντελεστεί συμβάλλουν στην αποτελεσματικότερη επίτευξη της αποστολής και του σκοπού των αποκεντρωμένων κρατικών υπηρεσιών. Βασική υπόθεση της εργασίας είναι ότι οι αλλαγές του θεσμού της Αποκεντρωμένης Διοίκησης υπηρετούν το συγκεντρωτικό χαρακτήρα του ελληνικού κράτους και έρχονται σε αντίθεση με τις εξελίξεις ως προς την αποκέντρωση σε ευρωπαϊκό επίπεδο. Παρόλο που οι Αποκεντρωμένες Διοικήσεις δύνανται να συντελέσουν όχι μόνο στην άρτια λειτουργία του κρατικού μηχανισμού, αλλά και στην ενδυνάμωση της τοπικής αυτοδιοίκησης, ως βαθμίδες ενιαίας περιφερειακής κρατικής διοίκησης που εξασφαλίζουν την παρουσία του κράτους πλησίον των πολιτών, όπως υπαγορεύει η αρχή της εγγύτητας, εντούτοις διαπιστώνεται μία τάση αποδυνάμωσης του ρόλου τους και σταδιακής αφαίμαξης των αρμοδιοτήτων τους.
Alterations of LKB1 and KRAS and risk of brain metastasis: Comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma
Creators: name: Stinchcombe, Thomas E.
name: Haithcock, Benjamin E.
name: Hayward, Michele C.
name: Roberts, Patrick
name: Wong, Kwok-Kin
name: Wang, Anyou
name: Grilley-Olson, Juneko E.
name: Parsons, Alden M.
name: Lee, Carrie B.
name: Sharpless, Norman E.
name: Thorne, Leigh B.
name: Funkhouser, William K.
name: Hayes, D. Neil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Brain metastases are one of the most malignant complications of lung cancer and constitute a significant cause of cancer related morbidity and mortality worldwide. Recent years of investigation suggested a role of LKB1 in NSCLC development and progression, in synergy with KRAS alteration. In this study, we systematically analyzed how LKB1 and KRAS alteration, measured by mutation, gene expression (GE) and copy number (CN), are associated with brain metastasis in NSCLC.
Transport through nanochannels driven by electric fields and temperature gradients
Creators: name: Hardt, Steffen
Publisher: name: Zenodo
Year: 2023
Subjects: energy harvesting
waste heat
waste heat recovery
nanofluidics
electrochemistry
nanochannels
ion intercalation
Seebeck coefficient

description: Dr. Steffen Hardt delivered this lecture on and presented TRANSLATE project results at the Center for Enhanced Nanofluidic Transport (CENT), MIT.
description: TRANSLATE is a €3.4 million EU-funded research project that aims to develop a new nanofluidic platform technology to effectively convert waste heat to electricity. This technology has the potential to improve the energy efficiency of many devices and systems, and provide a radically new zero-emission power source. The TRANSLATE project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 964251, for the action of 'The Recycling of waste heat through the Application of Nanofluidic ChannelS: Advances in the Conversion of Thermal to Electrical energy'. More information can be be found on the TRANSLATE project website: https://translate-energy.eu/
Noise kernels of stochastic gravity in conformally-flat spacetimes
Creators: name: Cho, H. T.
name: Hu, B. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The central object in the theory of semiclassical stochastic gravity is the noise kernel which is the symmetric two point correlation function of the stress-energy tensor. Using the corresponding Wightman functions in Minkowski, Einstein and open Einstein spaces, we construct the noise kernels of a conformally coupled scalar field in these spacetimes. From them we show that the noise kernels in conformally-flat spacetimes, including the Friedmann-Robertson-Walker universes, can be obtained in closed analytic forms by using a combination of conformal and coordindate transformations.
description: 18 pages, no figures
MEK inhibition in non-small cell lung cancer
Creators: name: Stinchcombe, Thomas E.
name: Johnson, Gary L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: KRAS mutations are the most common mutations in non-small cell lung cancer (NSCLC) with adenocarcinoma histology. KRAS mutations result in the activation of the RAF-MEK-ERK pathway, and agents that target RAF-MEK-ERK pathways have been investigated in KRAS mutant NSCLC. The two agents furthest in development are selumetinib and trametinib. Trametinib has greater binding for the MEK1/2 allosteric site, and generally has superior pharmacokinetics. A randomized phase II trial of docetaxel with and without selumetinib revealed that the combination resulted numerically superior overall survival, and a statistically significant improvement in progression-free survival and objective response rate. However, a concerning rate of hospital admission, grade 3 or 4 neutropenia, and febrile neutropenia was observed with the combination. Trials have investigated MEK inhibitors as single agents, and in combination with erlotinib or chemotherapy. The data do not support the further development of single agent MEK inhibitors or in combination with erlotinib. The activity of MEK inhibitors appears to be similar in patients with KRAS mutant and wild-type NSCLC suggesting KRAS mutation status is not a reliable biomarker for efficacy. It is possible that mutations of genes in addition to KRAS mutations impact the activity of MEK inhibitors, or specific subsets of KRAS mutations may be resistant or susceptible to MEK inhibition. Other potential explanations are gene amplifications, alternative RNA splicing of genes resulting in activation of their protein products, and deregulation of noncoding RNAs and consequent altered protein expression.
QPU-System Co-Design for Quantum HPC Accelerators
Creators: name: Wintersperger, Karen
name: Safi, Hila
name: Mauerer, Wolfgang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Hardware Architecture (cs.AR)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The use of quantum processing units (QPUs) promises speed-ups for solving computational problems, but the quantum devices currently available possess only a very limited number of qubits and suffer from considerable imperfections. One possibility to progress towards practical utility is to use a co-design approach: Problem formulation and algorithm, but also the physical QPU properties are tailored to the specific application. Since QPUs will likely be used as accelerators for classical computers, details of systemic integration into existing architectures are another lever to influence and improve the practical utility of QPUs. In this work, we investigate the influence of different parameters on the runtime of quantum programs on tailored hybrid CPU-QPU-systems. We study the influence of communication times between CPU and QPU, how adapting QPU designs influences quantum and overall execution performance, and how these factors interact. Using a simple model that allows for estimating which design choices should be subjected to optimisation for a given task, we provide an intuition to the HPC community on potentials and limitations of co-design approaches. We also discuss physical limitations for implementing the proposed changes on real quantum hardware devices.
Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups
Creators: name: Ganti, Apar Kishor
name: Wang, Xiaofei
name: Sargent, Daniel J.
name: Richards, William
name: Vokes, Everett
name: Pang, Herbert
name: Gu, Lin
name: Crawford, Jeffery
name: Stinchcombe, Thomas
name: Zhang, Ying
name: Cohen, Harvey Jay
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Prognostic models have been proposed to predict survival for non-small-cell lung cancer (NSCLC). It is important to evaluate whether these models perform better than performance status (PS) alone in stage- and age-specific subgroups.
title: Το δημοψήφισμα της 5ης Ιουλίου 2015 Μια αποτίμηση από δημοκρατική σκοπιά
title: The referendum of July 5, 2015 An assessment from a democratic perspective
titleType: AlternativeTitle
Creators: name: Κρουστάλη, Βασιλική
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Δημοψήφισμα
subject: Κοινωνική επιλογή
subject: Άμεση δημοκρατία
subject: Δημοψήφισμα
subject: Άμεση Δημοκρατία
subject: ΣΥΡΙΖΑ
subject: Ευρωπαϊκή Ένωση
subject: Grexit

description: Το δημοψήφισμα της 5ης Ιουλίου 2015 έχει καταγραφεί ως μία παράδοξη εμπειρία για το λαό και τους δημοκρατικούς θεσμούς στην Ελλάδα. Ένα θέμα που αν και έχει πάψει να απασχολεί το δημόσιο και ιδιωτικό διάλογο στην ελληνική κοινωνία, αποτελεί ένα γόνιμο πεδίο επιστημονικής σπουδής και ανάλυσης λόγω των ειδικών χαρακτηριστικών του, αλλά και του ενδιαφέροντος που παρουσιάζουν οι θεσμοί της άμεσης δημοκρατίας στα σύγχρονα αντιπροσωπευτικά συστήματα και στην ευρωπαϊκή διακυβέρνηση. Μέσα από τη διεθνή και ελληνική βιβλιογραφία παρουσιάζουμε τη θέση του θεσμού στην ελληνική πολιτική κουλτούρα, προσεγγίζουμε το θεωρητικό πλαίσιο και επιχειρούμε την αποτίμηση του δημοψηφίσματος της 5ης Ιουλίου 2015 από δημοκρατική σκοπιά.
Controllable particle migration in liquid crystal flows
Creators: name: Lesniewska, Magdalena
name: Mottram, Nigel
name: Henrich, Oliver
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We observe novel positional control of a colloidal particle in microchannel flow of a nematic liquid crystal. Lattice Boltzmann simulations show multiple equilibrium particle positions, the existence and position of which are tunable using the driving pressure, in direct contrast to the classical Segre-Silberberg effect in isotropic liquids. In addition, particle migration in nematic flow occurs an order of magnitude faster. These new equilibria are determined through a balance of elastic forces, hydrodynamic lift and drag as well as order-flow interactions through the defect structure around the particle.
description: 13 pages, 10 figures, 1 table; to be published in Soft Matter
Conditions for supersonic bent Marshak waves
Creators: name: Xu, Qiang
name: Ren, Xiao-dong
name: Li, Jing
name: Dan, Jia-kun
name: Wang, Kun-lun
name: Zhou, Shao-tong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Supersonic radiation diffusion approximation is a useful way to study the radiation transportation. Considering the bent Marshak wave theory in 2-dimensions, and an invariable source temperature, we get the supersonic radiation diffusion conditions which are about the Mach number $M>8(1+\sqrt{\ep})/3$, and the optical depth $τ>1$. A large Mach number requires a high temperature, while a large optical depth requires a low temperature. Only when the source temperature is in a proper region these conditions can be satisfied. Assuming the material opacity and the specific internal energy depend on the temperature and the density as a form of power law, for a given density, these conditions correspond to a region about source temperature and the length of the sample. This supersonic diffusion region involves both lower and upper limit of source temperature, while that in 1-dimension only gives a lower limit. Taking $\rm SiO_2$ and the Au for example, we show the supersonic region numerically.
description: 9 pages, 5 figures
Fab-based bispecific antibody formats with robust biophysical properties and biological activity
Creators: name: Lewis, Steven M
name: Fine, Cody
name: Kuhlman, Brian
name: Sereno, Arlene J
name: Demarest, Stephen J
name: Batt, Micheal A
name: Fitchett, Jonathan R
name: Lieu, Ricky L
name: Weldon, Caroline
name: Huang, Flora
name: Torres, Carina
name: Glasebrook, Andrew L
name: Wu, Xiufeng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A myriad of innovative bispecific antibody (BsAb) platforms have been reported. Most require significant protein engineering to be viable from a development and manufacturing perspective. Single-chain variable fragments (scFvs) and diabodies that consist only of antibody variable domains have been used as building blocks for making BsAbs for decades. The drawback with Fv-only moieties is that they lack the native-like interactions with CH1/CL domains that make antibody Fab regions stable and soluble. Here, we utilize a redesigned Fab interface to explore 2 novel Fab-based BsAbs platforms. The redesigned Fab interface designs limit heavy and light chain mixing when 2 Fabs are co-expressed simultaneously, thus allowing the use of 2 different Fabs within a BsAb construct without the requirement of one or more scFvs. We describe the stability and activity of a HER2×HER2 IgG-Fab BsAb, and compare its biophysical and activity properties with those of an IgG-scFv that utilizes the variable domains of the same parental antibodies. We also generated an EGFR × CD3 tandem Fab protein with a similar format to a tandem scFv (otherwise known as a bispecific T cell engager or BiTE). We show that the Fab-based BsAbs have superior biophysical properties compared to the scFv-based BsAbs. Additionally, the Fab-based BsAbs do not simply recapitulate the activity of their scFv counterparts, but are shown to possess unique biological activity.
Secondary Rayleigh-Taylor type Instabilities in the Reconnection Exhaust Jet as a Mechanism for Supra-Arcade Downflows
Creators: name: Guo, L. -J.
name: Bhattacharjee, A.
name: Huang, Y. -M.
name: Innes, Davina E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Supra-arcade downflows (hereafter referred to as SADs) are low-emission, elongated, finger-like features usually observed in active-region coronae above post-eruption flare arcades. Observations exhibit downward moving SADs intertwined with bright upward moving spikes. Whereas SADs are dark voids, spikes are brighter, denser structures. Although SADs have been observed for decades, the mechanism of formation of SADs remains an open issue. In our three-dimensional resistive magnetohydrodynamic simulations, we demonstrate that secondary Rayleigh-Taylor type instabilities develop in the downstream region of a reconnecting current sheet. The instability results in the formation of low-density coherent structures that resemble SADs, and high-density structures that appear to be spike-like. Comparison between the simulation results and observations suggests that secondary Rayleigh-Taylor type instabilities in the exhaust of reconnecting current sheets provide a plausible mechanism for observed SADs and spikes.
End-Monomer Dynamics in Semiflexible Polymers
Creators: name: Krichevsky, Oleg
name: Netz, Roland R.
name: Schlagberger, Xaver
name: Hinczewski, Michael
name: Rubinstein, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Spurred by an experimental controversy in the literature, we investigate the end-monomer dynamics of semiflexible polymers through Brownian hydrodynamic simulations and dynamic mean-field theory. Precise experimental observations over the last few years of end-monomer dynamics in the diffusion of double-stranded DNA have given conflicting results: one study indicated an unexpected Rouse-like scaling of the mean squared displacement (MSD) 〈r2(t)〉 ~ t1/2 at intermediate times, corresponding to fluctuations at length scales larger than the persistence length but smaller than the coil size; another study claimed the more conventional Zimm scaling 〈r2(t)〉 ~ t2/3 in the same time range. Using hydrodynamic simulations, analytical and scaling theories, we find a novel intermediate dynamical regime where the effective local exponent of the end-monomer MSD, α(t) = d log〈r2(t)〉/d log t, drops below the Zimm value of 2/3 for sufficiently long chains. The deviation from the Zimm prediction increases with chain length, though it does not reach the Rouse limit of 1/2. The qualitative features of this intermediate regime, found in simulations and in an improved mean-field theory for semiflexible polymers, in particular the variation of α(t) with chain and persistence lengths, can be reproduced through a heuristic scaling argument. Anomalously low values of the effective exponent α are explained by hydrodynamic effects related to the slow crossover from dynamics on length scales smaller than the persistence length to dynamics on larger length scales.
Balanophora hookeriana , Hemsl
Creators: name: Hemsley
Publisher: name: Zenodo
Year: 1894
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Santalales
Balanophoraceae
Balanophora
Balanophora hookeriana

description: 80. Balanophora hookeriana, Hemsl. [Balanophorae]; planta minima ♀ gracilis, caule paucisquamosa, squamis latis amplexicaulibus rotundatis superioribus quam internodiis brevioribus, spica brvis breviter pedunculata, floribus bene evolutis non visis sessilibus cum bracteis clavatis intermixtis. Habitat. - Myrung, Khasia mountains,J.D. Hooker and T. Thomson, 1850. Planta circiter 1 1/4 poll. alta. Squamae mximae sesquilineam longae. Spica ♀ vix sesquilineam longa. The history of this miniature Balanophora is very curious. Last year, when transferring some spirit-specimens of Cordyceps to the Herbarium, Mr. Massee found the plant in question, which he soon ascertained was not a fungus; yet, on comparing it with Berkeley's original drawing of Cordyceps racemosa, publihsed at the same time as C. falcata in Hooker's Kew Journal of Botany, vi. p. 212, t. 8, fig 3, it appeared to be the organism from which a part of at least of the drawing was made. The original drawing shows the scales on the stem, but the published figure does not, and strange to say Berkeley concludes this description of Cordyceps racemosa with the remark that it might easily be passed over as an imperfect Balanophora. It would appear that he fell into an inexplicable blunder, for there is nothing else to represent Cordyceps.
description: Published as part of Hemsley, 1894, CCCLXVIII. Decades Kewensis. Plantarum Novarum in Herbario Horti Regii Conservatorum. Decas VIII., pp. 99-102 in Bulletin of miscellaneous information 1894 on page 102, DOI: 10.5281/zenodo.44762
Self-organized criticality in a spherically closed cellular automaton: Modeling soft gamma repeater bursts driven by magnetic reconnection
Creators: name: Nakazato, Ken'ichiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: A new cellular automaton (CA) model is presented for the self-organized criticality (SOC) in recurrent bursts of soft gamma repeaters (SGRs), which are interpreted as avalanches of reconnection in the magnetosphere of neutron stars. The nodes of a regular dodecahedron and a truncated icosahedron are adopted as spherically closed grids enclosing a neutron star. It is found that the system enters the SOC state if there are sites where the expectation value of the added perturbation is nonzero. The energy distributions of SOC avalanches in CA simulations are described by a power law with a cutoff, which is consistent with the observations of SGR 1806-20 and SGR 1900+14. The power-law index is not universal and depends on the amplitude of the perturbation. This result shows that the SOC of SGRs can be illustrated not only by the crust quake model but also by the magnetic reconnection model.
description: 6 pages, 5 figures, references corrected, accepted for publication in PRD
title: Η Ευρωπαϊκή Πολιτική Γειτονίας της ΕΕ υπό το πρίσμα της πολυεπίπεδης διακυβέρνησης – Η συνεργασία με τους Νότιους Εταίρους
title: The EU's European Neighbourhood Policy in the light of multi-level governance – Cooperation with the Southern Partners
titleType: AlternativeTitle
Creators: name: Μπάκα, Γεωργία
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Συγκριτική διακυβέρνηση
subject: Ευρωπαϊκή Ένωση
subject: Ευρωπαϊκή Ένωση, Χώρες της--Πολιτική και διακυβέρνηση
subject: Πολυεπίπεδη Διακυβέρνηση
subject: Ευρωπαϊκή Πολιτική Γειτονίας
subject: Τοπικές και Περιφερειακές Αρχές
subject: Νότιοι Εταίροι
subject: ARLEM

description: H έννοια της πολυεπίπεδης διακυβέρνησης έχει υπάρξει μια από τις δημοφιλέστερες θεωρίες για την επεξήγηση της χάραξης των ευρωπαϊκών πολιτικών και του τρόπου διάχυσης ευθυνών μεταξύ των διαφόρων δρώντων σε υποεθνικό, εθνικό και υπερεθνικό επίπεδο που συμμετέχουν σε αυτή την διαδικασία. Στην παρούσα εργασία θα αναφερθούν αρχικά οι ιστορικές συγκυρίες που οδήγησαν στην ανάδειξη της έννοιας της πολυεπίπεδης διακυβέρνησης στο ευρωπαϊκό πλαίσιο, στην εμφάνιση της στην ακαδημαϊκή βιβλιογραφία, στη συμβολή της ως θεωρία ευρωπαϊκής ολοκλήρωσης, όπως και στην προώθηση της χρήση της στα θεσμικά όργανα της ΕΕ. Επίκεντρο της εργασίας είναι η μελέτη της Ευρωπαϊκής Πολιτικής Γειτονίας (ΕΠΓ), ως μέσο εξωτερίκευσης του πολυεπίπεδου τρόπου διακυβέρνησης και μεταλαμπάδευσης των ευρωπαϊκών ιδανικών σε χώρες που δεν αποτελούν κράτη – μέλη της ΕΕ. Η ΕΠΓ θα ερμηνευτεί υπό το πρίσμα της συνεργασίας με τους Νότιους Εταίρους. Τέλος, θα παρουσιαστεί τόσο ο ρόλος των περιφερειακών και τοπικών αρχών στο συγκεκριμένο μοντέλο διακυβέρνησης, όσο και ένα αντιπροσωπευτικό παράδειγμα μεσογειακής περιφερειακής εκπροσώπησης στα ευρωπαϊκά τεκταινόμενα, η Ευρωμεσογειακή Περιφερειακή και Τοπική Συνέλευση (ARLEM).
Eruptions of Two Coupled Filaments Observed by SDO, GONG and STEREO
Creators: name: Xue, Z. K.
name: Yan, X. L.
name: Qu, Z. Q.
name: Xu, C. L.
name: Zhao, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: On 2012 July 11, two solar filaments were observed in the northeast of the solar disk and their eruptions due to the interaction between them are studied by using the data from the Solar Dynamics Observatory (SDO), Solar TErrestrial RElations Observatory (STEREO) and Global Oscillation Network Group (GONG). The eastern filament (F1) first erupted toward the northeast. During the eruption of F1, some plasma from F1 fell down and was injected to the North-East part of another filament (F2), and some plasma of F1 fell down to the northern region close to F2 and caused the plasma to brighten. Meanwhile, the North-East part of F2 first started to be active and rise, but did not erupt finally. Then the South-West part of F2 erupted successfully. Therefore, the F2's eruption is a partial filament eruption. Two associated CMEs related to the eruptions were observed by STEREO/COR1. We find two possible reasons that lead to the instability and the eruption of F2. One main reason is that the magnetic loops overlying the two filaments were partially opened by the eruptive F1 and resulted in the instability of F2. The other is that the downflows from F1 might break the stability of F2.
description: 12 pages, 7 figures. Accepted for publication in Astrophysics and Space Science
NiSe2 modified Carbon Fibre Cloth as the High- Performance electrode for Thermally Chargeable Super Capacitors
Creators: name: Ranjani Palanisamy, Rupa
name: N, Padmanathan
name: Biswas, Subhajit
name: Razeeb M., Kafil
name: D. Holmes, Justin
Publisher: name: Zenodo
Year: 2023
Subjects: energy harvesting
waste heat
waste heat recovery
nanofluidics
electrochemistry
nanochannels
ion intercalation
Seebeck coefficient

description: Rupa Ranjani Palanisamy (PhD student) presented at the 74th Irish Universities Chemistry Research Colloquium, University of Galway on 14-15 June 2023 in Galway, Ireland.
description: TRANSLATE is a €3.4 million EU-funded research project that aims to develop a new nanofluidic platform technology to effectively convert waste heat to electricity. This technology has the potential to improve the energy efficiency of many devices and systems, and provide a radically new zero-emission power source. The TRANSLATE project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 964251, for the action of 'The Recycling of waste heat through the Application of Nanofluidic ChannelS: Advances in the Conversion of Thermal to Electrical energy'. More information can be be found on the TRANSLATE project website: https://translate-energy.eu/
A taxonomy of surprise definitions
Creators: name: Modirshanechi, Alireza
name: Brea, Johanni
name: Gerstner, Wulfram
Publisher: name: arXiv
Year: 2022
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Machine Learning (stat.ML)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Surprising events trigger measurable brain activity and influence human behavior by affecting learning, memory, and decision-making. Currently there is, however, no consensus on the definition of surprise. Here we identify 18 mathematical definitions of surprise in a unifying framework. We first propose a technical classification of these definitions into three groups based on their dependence on an agent's belief, show how they relate to each other, and prove under what conditions they are indistinguishable. Going beyond this technical analysis, we propose a taxonomy of surprise definitions and classify them into four conceptual categories based on the quantity they measure: (i) 'prediction surprise' measures a mismatch between a prediction and an observation; (ii) 'change-point detection surprise' measures the probability of a change in the environment; (iii) 'confidence-corrected surprise' explicitly accounts for the effect of confidence; and (iv) 'information gain surprise' measures the belief-update upon a new observation. The taxonomy poses the foundation for principled studies of the functional roles and physiological signatures of surprise in the brain.
description: To appear in the Journal of Mathematical Psychology