cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
Creators: name: Avkin, Sharon
name: Ziv, Omer
name: Chaney, Stephen
name: Shachar, Sigal
name: Friedberg, Errol C.
name: Carell, Thomas
name: Adar, Sheera
name: Livneh, Zvi
name: Geacintov, Nicholas
name: Reißner, Thomas
name: Wittschieben, John
name: Wang, Zhigang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Correction to: The EMBO Journal (2009) 28, 383–393. doi:10.1038/emboj.2008.281
An end-to-end KNN-based PTV approach for high-resolution measurements and uncertainty quantification
Creators: name: Tirelli, Iacopo
name: Ianiro, Andrea
name: Discetti, Stefano
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We introduce a novel end-to-end approach to improving the resolution of PIV measurements. The method blends information from different snapshots without the need for time-resolved measurements on grounds of similarity of flow regions in different snapshots. The main hypothesis is that, with a sufficiently large ensemble of statistically-independent snapshots, the identification of flow structures that are morphologically similar but occurring at different time instants is feasible. Measured individual vectors from different snapshots with similar flow organisation can thus be merged, resulting in an artificially increased particle concentration. This allows to refine the interrogation region and, consequently, increase the spatial resolution. The measurement domain is split in subdomains. The similarity is enforced only on a local scale, i.e. morphologically-similar regions are sought only among subdomains corresponding to the same flow region. The identification of locally-similar snapshots is based on unsupervised K-nearest neighbours search in a space of significant flow features. Such features are defined in terms of a Proper Orthogonal Decomposition, performed in subdomains on the original low-resolution data, obtained either with standard cross-correlation or with binning of Particle Tracking Velocimetry data with a relatively large bin size. A refined bin size is then selected according to the number of "sufficiently close" snapshots identified. The statistical dispersion of the velocity vectors within the bin is then used to estimate the uncertainty and to select the optimal K which minimises it. The method is tested and validated against datasets with a progressively increasing level of complexity: two virtual experiments based on direct simulations of the wake of a fluidic pinball and a channel flow and the experimental data collected in a turbulent boundary layer.
Symmetric Tops Subject to Combined Electric Fields: Conditional Quasi-Solvability via the Quantum Hamilton-Jacobi Theory
Creators: name: Schatz, Konrad
name: Friedrich, Bretislav
name: Becker, Simon
name: Schmidt, Burkhard
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We make use of the Quantum Hamilton-Jacobi (QHJ) theory to investigate conditional quasi-solvability of the quantum symmetric top subject to combined electric fields (symmetric top pendulum). We derive the conditions of quasi-solvability of the time-independent Schroedinger equation as well as the corresponding finite sets of exact analytic solutions. We do so for this prototypical trigonometric system as well as for its anti-isospectral hyperbolic counterpart. An examination of the algebraic and numerical spectra of these two systems reveals mutually closely related patterns. The QHJ approach allows to retrieve the closed-form solutions for the spherical and planar pendula and the Razavy system that had been obtained in our earlier work via Supersymmetric Quantum Mechanics as well as to find a cornucopia of additional exact analytic solutions.
Homotopy Theory of Bicomplexes
Creators: name: Muro, Fernando
name: Roitzheim, Constanze
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Topology (math.AT)
subject: K-Theory and Homology (math.KT)
subject: FOS: Mathematics

description: We define two model structures on the category of bicomplexes concentrated in the right half plane. The first model structure has weak equivalences detected by the totalisation functor. The second model structure's weak equivalences are detected by the $E^2$-term of the spectral sequence associated to the filtration of the total complex by the horizontal degree. We then extend this result to twisted complexes.
description: 26 pages
Skew cyclic codes over $\mathbb{F}_{q}+v\mathbb{F}_{q}+v^{2}\mathbb{F}_{q}$
Creators: name: Shi, Minjia
name: Yao, Ting
name: Alahmadi, Adel
name: Solé, Patrick
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this article, we study skew cyclic codes over ring $R=\mathbb{F}_{q}+v\mathbb{F}_{q}+v^{2}\mathbb{F}_{q}$, where $q=p^{m}$, $p$ is an odd prime and $v^{3}=v$. We describe generator polynomials of skew cyclic codes over this ring and investigate the structural properties of skew cyclic codes over $R$ by a decomposition theorem. We also describe the generator polynomials of the duals of skew cyclic codes. Moreover, the idempotent generators of skew cyclic codes over $\mathbb{F}_{q}$ and $R$ are considered.
description: This manuscript has been accepted by a magazine. arXiv admin note: text overlap with arXiv:1504.07831
The Use of Latent Trajectory Models in Psychopathology Research.
Creators: name: Curran, Patrick J.
name: Hussong, Andrea M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Despite the recent surge in the development of powerful modeling strategies to test questions about individual differences in stability and change over time, these methods are not currently widely used in psychopathology research. In an attempt to further the dissemination of these new methods, the authors present a pedagogical introduction to the structural equation modeling based latent trajectory model, or LTM. They review several different types of LTMs, discuss matching an optimal LTM to a given question of interest, and highlight several issues that might be particularly salient for research in psychopathology. The authors augment each section with a review of published applications of these methods in psychopathology-related research to demonstrate the implementation and interpretation of LTMs in practice.
Table S4 from Characterization of columnar inertial modes in rapidly rotating spheres and spheroids.
Creators: name: Maffei, Stefano
name: Jackson, Andrew
name: Livermore, Philip W.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences
subject: 10599 Mathematical Physics not elsewhere classified
subject: FOS: Mathematics
subject: 19999 Mathematical Sciences not elsewhere classified

description: Some values of the decay factor τ due to stress-free boundary condition calculated for di↵erent values of N and m for the 3-D inertial modes with the lowest vertical complexity and with the smallest (in absolute value) eigenfrequency.
Hybrid RIS and DMA Assisted Multiuser MIMO Uplink Transmission With Electromagnetic Exposure Constraints
Creators: name: Jiang, Hanyu
name: You, Li
name: Wang, Jue
name: Wang, Wenjin
name: Gao, Xiqi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Theory (cs.IT)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In the fifth-generation and beyond era, reconfigurable intelligent surface (RIS) and dynamic metasurface antennas (DMAs) are emerging metamaterials keeping up with the demand for high-quality wireless communication services, which promote the diversification of portable wireless terminals. However, along with the rapid expansion of wireless devices, the electromagnetic (EM) radiation increases unceasingly and inevitably affects public health, which requires a limited exposure level in the transmission design. To reduce the EM radiation and preserve the quality of communication service, we investigate the spectral efficiency (SE) maximization with EM constraints for uplink transmission in hybrid RIS and DMA assisted multiuser multiple-input multiple-output systems. Specifically, alternating optimization is adopted to optimize the transmit covariance, RIS phase shift, and DMA weight matrices. We first figure out the water-filling solutions of transmit covariance matrices with given RIS and DMA parameters. Then, the RIS phase shift matrix is optimized via the weighted minimum mean square error, block coordinate descent and minorization-maximization methods. Furthermore, we solve the unconstrainted DMA weight matrix optimization problem in closed form and then design the DMA weight matrix to approach this performance under DMA constraints. Numerical results confirm the effectiveness of the EM aware SE maximization transmission scheme over the conventional baselines.
description: 14 pages, 6 figures
Single Channel Properties of Heterotetrameric Mutant RyR1 Ion Channels Linked to Core Myopathies
Creators: name: Yamaguchi, Naohiro
name: Meissner, Gerhard
name: Xu, Le
name: Pasek, Daniel A.
name: Wang, Ying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Skeletal muscle excitation-contraction coupling involves activation of homotetrameric ryanodine receptor ion channels (RyR1s), resulting in the rapid release of Ca2+ from the sarcoplasmic reticulum. Previous work has shown that Ca2+ release is impaired by mutations in RyR1 linked to Central Core Disease and Multiple Minicore Disease. We studied the consequences of these mutations on RyR1 function, following their expression in human embryonic kidney 293 cells and incorporation in lipid bilayers. RyR1-G4898E, -G4898R, and -ΔV4926/I4927 mutants in the C-terminal pore region of RyR1 and N-terminal RyR1-R110W/L486V mutant all showed negligible Ca2+ permeation and loss of Ca2+-dependent channel activity but maintained reduced K+ conductances. Co-expression of wild type and mutant RyR1s resulted in Ca2+-dependent channel activities that exhibited intermediate Ca2+ selectivities compared with K+, which suggested the presence of tetrameric RyR1 complexes composed of wild type and mutant subunits. The number of wild-type subunits to maintain a functional heterotetrameric channel differed among the four RyR1 mutants. The results indicate that homozygous RyR1 mutations associated with core myopathies abolish or greatly reduce sarcoplasmic reticulum Ca2+ release during excitation-contraction coupling. They further suggest that in individuals, expressing wild type and mutant alleles, a substantial portion of RyR1 channels is able to release Ca2+ from sarcoplasmic reticulum.
Download PDF Connaissance illimitée
Creators: name: Angle
Publisher: name: Zenodo
Year: 2024

description: Connaissance illimitée pan Mohamed Boclet

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Connaissance illimitée

Mohamed Boclet

Nb. de pages: 167

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782221266632

Editeur: Robert Laffont

Date de parution: 2023

 

 

 

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Overview

Découvrir ses intelligences, déjouer l'autosabotage, pratiquer la lecture rapide et mémoriser l'impossible en s'amusant : hackez votre cerveau ! Réapprenez à apprendre et exploitez votre potentiel illimité ! Qui n'a jamais eu envie de découvrir un nouveau métier ou de reprendre ses études ? de maîtriser une langue étrangère ? de travailler plus efficacement ? Tout cela, dans la joie ! En échec scolaire durant sa jeunesse, Mohamed Boclet est devenu vice-champion du monde de lecture rapide en développant des techniques d'apprentissage simples et efficaces. Dans ce livre, il partage ses méthodes pour vous permettre de renforcer votre concentration, d'accroître vos connaissances et de booster vos facultés intellectuelles. Vous aussi, vous pouvez abandonner vos croyances limitantes, prendre des habitudes élémentaires de lecture rapide, créer des mind maps pour stimuler votre capacité de mémorisation et vous organiser de manière ergonomique pour aller au bout de vos projets ! Devenir illimité c'est : Identifier vos intelligences et apprendre à les utiliser Développer vos talents et les démultiplier. Prendre confiance en vous en restant fidèle à votre personnalité. Augmenter vos connaissances pour davantage d'épanouissement professionnel et personnel.
Endoplasmic Reticulum/Golgi Nucleotide Sugar Transporters Contribute to the Cellular Release of UDP-sugar Signaling Molecules
Creators: name: Kreda, Silvia M.
name: Nicholas, Robert A.
name: Nishihara, Shoko
name: Lazarowski, Eduardo R.
name: O'Neal, Wanda
name: Esther Jr., Charles R.
name: Jones, Lisa
name: Sesma, Juliana I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Extracellular UDP-sugars promote cellular responses by interacting with widely distributed P2Y14 receptors, but the mechanisms by which these molecules are released from cells are poorly understood. Given the active role of UDP-sugars in glycosylation reactions within the secretory pathway, we hypothesized that UDP-sugar release includes an exocytotic component. This hypothesis was tested by assessing the contribution of endoplasmic reticulum (ER)/Golgi-resident UDP-GlcNAc transporters to the cellular release of their cognate substrates. A sensitive and highly selective assay for UDP-GlcNAc mass was developed using purified AGX2, an isoenzyme of human UDP-GlcNAc pyrophosphorylase. Robust constitutive release of UDP-GlcNAc was observed in yeast as well as in well differentiated human airway epithelial cells. The human UDP-GlcNAc transporter HFRC1 was overexpressed in human bronchial epithelial cells and was shown to localize in the Golgi and to enhance the surface expression of N-acetylglucosamine-rich glycans. HFRC1-overexpressing cells also displayed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc. Yeast mutants lacking Yea4 (the ER UDP-GlcNAc transporter endogenously expressed in Saccharomyces cerevisiae) showed reduced UDP-GlcNAc release. Yea4-deficient cells complemented with Yea4 showed UDP-GlcNAc release rates at levels similar to or higher than wild type cells. Our results illustrate that ER/Golgi lumen constitutes a significant source of extracellular UDP-sugars and therefore plays a critical role in nucleotide sugar-promoted cell signaling.
Table S4 from Characterization of columnar inertial modes in rapidly rotating spheres and spheroids
Creators: name: Maffei, Stefano
name: Jackson, Andrew
name: Livermore, Philip W.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Geophysics
subject: FOS: Earth and related environmental sciences
subject: 10599 Mathematical Physics not elsewhere classified
subject: FOS: Mathematics
subject: 19999 Mathematical Sciences not elsewhere classified

description: Some values of the decay factor τ due to stress-free boundary condition calculated for di↵erent values of N and m for the 3-D inertial modes with the lowest vertical complexity and with the smallest (in absolute value) eigenfrequency.
EL PRÍNCIPE Y LA PASTELERA EMMA CHASE ePub gratis
Creators: name: Foutch
Publisher: name: Zenodo
Year: 2024

description: EL PRÍNCIPE Y LA PASTELERA de EMMA CHASE

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EL PRÍNCIPE Y LA PASTELERA

EMMA CHASE

Número de páginas: 324

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788412676563

Editorial: VR EUROPA

Año de edición: 2023

 

 

 

 

 

Descargar libros completos en pdf. EL PRÍNCIPE Y LA PASTELERA PDF PDB FB2 9788412676563

 

Overview

Érase una vez, Nicholas Pembrook, príncipe heredero de Wessco, popularmente conocido como «su cuerpazo real». Encantador, atractivo y rico, tiene el mundo a sus pies (literalmente).Érase una vez, Olivia Hammond, humilde pastelera de Nueva York. Preciosa, trabajadora y sin una pizca de paciencia para tíos arrogantes.Érase una vez, una noche de tormenta en Manhattan, en la que el príncipe conoce a la pastelera y… ella le estampa un pastel en la cara.Olivia no espera volver a ver a Nicholas, pero él se ha quedado con el sabor dulce en los labios y pretende conquistar a Olivia, cueste lo que cueste. Y, poco a poco, ella irá descubriendo que detrás de las sonrisas del príncipe se esconde un gran corazón.Pero esto no es un cuento. En el mundo real no hay hadas madrinas, pero sí una reina estirada que, a pesar de que no corta cabezas, no está dispuesta a que una plebeya se acerque al trono… o a su príncipe.Nicholas y Olivia tendrán que hacerse una pregunta: ¿amor o deber?
On the Performance of Multi-Antenna Wireless-Powered Communications with Energy Beamforming
Creators: name: Huang, Wenzhu
name: Chen, He
name: Li, Yonghui
name: Vucetic, Branka
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, we study the average throughput performance of energy beamforming in a multi-antenna wireless-powered communication network (WPCN). The considered network consists of one hybrid access-point (AP) with multiple antennas and a single antenna user. The user does not have constant power supply and thus needs to harvest energy from the signals broadcast by the AP in the downlink (DL), before sending its data back to the AP with the harvested energy in the uplink (UL). We derive closed-form expressions of the average throughput and their asymptotic expressions at high SNR for both delay-limited and delay-tolerant transmission modes. The optimal DL energy harvesting time, which maximizes the system throughput, is then obtained for high SNR. All analytical expressions are validated by numerical simulations. The impact of various parameters, such as the AP transmit power, the energy harvesting time, and the number of antennas, on the system throughput is also investigated.
description: Accepted to appear in IEEE Transactions on Vehicular Technology
Electronic supplementary information from Odours from marine plastic debris induce food search behaviours in a forage fish.
Creators: name: Savoca, Matthew S.
name: Tyson, Chris W.
name: McGill, Michael
name: Slager, Christina J.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Plastic pollution is an anthropogenic stressor in marine ecosystems globally. Many species of marine fish (more than 50) ingest plastic debris. Ingested plastic has a variety of lethal and sublethal impacts and can be a route for bioaccumulation of toxic compounds throughout the food web. Despite its pervasiveness and severity, our mechanistic understanding of this maladaptive foraging behaviour is incomplete. Recent evidence suggests that the chemical signature of plastic debris may explain why certain species are predisposed to mistaking plastic for food. Anchovy (Engraulis sp.) are abundant forage fish in coastal upwelling systems and a critical prey resource for top predators. Anchovy ingest plastic in natural conditions, though the mechanism they use to misidentify plastic as prey is unknown. Here, we presented wild-caught schools of Northern Anchovy (Engraulis mordax) with odour solutions made of plastic debris and clean plastic to compare school-wide aggregation and rheotactic responses relative to food and food odour presentations. Anchovy schools responded to plastic debris odour with increased aggregation and reduced rheotaxis. These results were similar to the effects food and food odour presentations had on schools. Conversely, these behavioural responses were absent in clean plastic and control treatments. To our knowledge, this is the first experimental evidence that adult anchovy use odours to forage. We conclude that the chemical signature plastic debris acquires in the photic zone can induce foraging behaviours in anchovy schools. These findings provide further support for a chemosensory mechanism underlying plastic consumption by marine wildlife. Given the trophic position of forage fish, these findings have considerable implications for aquatic food webs and possibly human health.
Holographic Relative Entropy in Infinite-dimensional Hilbert Spaces
Creators: name: Kang, Monica Jinwoo
name: Kolchmeyer, David K.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We reformulate entanglement wedge reconstruction in the language of operator-algebra quantum error correction with infinite-dimensional physical and code Hilbert spaces. Von Neumann algebras are used to characterize observables in a boundary subregion and its entanglement wedge. Assuming that the infinite-dimensional von Neumann algebras associated with an entanglement wedge and its complement may both be reconstructed in their corresponding boundary subregions, we prove that the relative entropies measured with respect to the bulk and boundary observables are equal. We also prove the converse: when the relative entropies measured in an entanglement wedge and its complement equal the relative entropies measured in their respective boundary subregions, entanglement wedge reconstruction is possible. Along the way, we show that the bulk and boundary modular operators act on the code subspace in the same way. For holographic theories with a well-defined entanglement wedge, this result provides a well-defined notion of holographic relative entropy.
description: 35 pages, typos corrected and examples edited
Comparison of Spatio-Temporal Models for Human Motion and Pose Forecasting in Face-to-Face Interaction Scenarios
Creators: name: Barquero, German
name: Núñez, Johnny
name: Xu, Zhen
name: Escalera, Sergio
name: Tu, Wei-Wei
name: Guyon, Isabelle
name: Palmero, Cristina
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Human behavior forecasting during human-human interactions is of utmost importance to provide robotic or virtual agents with social intelligence. This problem is especially challenging for scenarios that are highly driven by interpersonal dynamics. In this work, we present the first systematic comparison of state-of-the-art approaches for behavior forecasting. To do so, we leverage whole-body annotations (face, body, and hands) from the very recently released UDIVA v0.5, which features face-to-face dyadic interactions. Our best attention-based approaches achieve state-of-the-art performance in UDIVA v0.5. We show that by autoregressively predicting the future with methods trained for the short-term future (<400ms), we outperform the baselines even for a considerably longer-term future (up to 2s). We also show that this finding holds when highly noisy annotations are used, which opens new horizons towards the use of weakly-supervised learning. Combined with large-scale datasets, this may help boost the advances in this field.
description: single column, 27 pages, 7 figures, 7 tables
An optical analogue for rotating BTZ black holes
Creators: name: Chen, Ling
name: Zhang, Hongbin
name: Zhang, Baocheng
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We demonstrate an optical realization for the rotating BTZ black hole using the recent popular photon fluid model in an optical vortex but with a new proposed expression for the optical phase. We also give the numerical realization for the optical vortex to ensure that it can be generated experimentally. Different from the earlier suggestions for the analogue rotating black holes, our proposal includes an inner horizon in the analogue black hole structure. Such structure can keep for a long distance for the convenience of observing analogue Hawking or Penrose radiations.
Study of grain boundary transparency in (Yb1-xCax)Ba2Cu3O bi-crystal thin films over a wide temperature, field and field orientation range
Creators: name: Li, Pei
name: Abraimov, Dmytro
name: Polyanskii, Anatolii
name: Kametani, Fumitake
name: Larbalestier, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The residual low angle grain boundary (GB) network is still the most important current-limiting mechanism operating in bi-axially textured rare earth barium copper oxide (REBCO) coated conductors. While Ca-doping is well established to improve super-current flow across low angle GBs in weak fields at high temperatures, Ca-doping also depresses Tc, making it so far impractical for high temperature applications of REBCO coated conductors. On the other hand, high field magnet applications of REBCO require low temperatures. Here we systematically evaluate the effectiveness of Ca-doping in improving the GB transparency, r$^{GB}$= Jc$^{GB}$/Jc$^{grain}$ , of low angle Yb1-xCaxBaCuO [001] tilt bi-crystal films down to 10K and with magnetic fields perpendicular and parallel to the film surfaces, while varying the Ca and oxygen doping level. Using Low Temperature Scanning Laser Microscopy (LTSLM) and Magneto-Optical Imaging (MOI), we found rGB to strongly depend on the angle between magnetic field and the GB plane and clearly identified regimes in which Jc$^{GB}$ can exceed Jc$^{grain}$ (r$^{GB}$>1) where the GB pinning is optimized by the field being parallel to the GB dislocations. However, even in this favorable situation, we found that r$^{GB}$ became much smaller at lower temperatures. Calculations of the GB Ca segregation profile predict that the high Jc channels between the GB dislocation cores are almost Ca-free. It may be therefore that the positive effects of Ca doping seen by many authors near Tc are partly a consequence of the higher Tc of these Ca-free channels.
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
Creators: name: Choi, Jun Hyuk
name: Sancar, Aziz
name: Lindsey-Boltz, Laura A.
name: Serçin, Özdemirhan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: ATR (ATM and Rad3-related) initiates a DNA damage signaling pathway in human cells upon DNA damage induced by UV and UV-mimetic agents and in response to inhibition of DNA replication. Genetic data with human cells and in vitro data with Xenopus egg extracts have led to the conclusion that the kinase activity of ATR toward the signal-transducing kinase Chk1 depends on the mediator protein Claspin. Here we have reconstituted a Claspin-mediated checkpoint system with purified human proteins. We find that the ATR-dependent phosphorylation of Chk1, but not p53, is strongly stimulated by Claspin. Similarly, DNA containing bulky base adducts stimulates ATR kinase activity, and Claspin acts synergistically with damaged DNA to increase phosphorylation of Chk1 by ATR. Mutations in putative phosphorylation sites in the Chk1-binding domain of Claspin abolish its ability to mediate ATR phosphorylation of Chk1. We also find that a fragment of Claspin containing the Chk1-binding domain together with a domain conserved in the yeast Mrc1 orthologs of Claspin is sufficient for its mediator activity. This in vitro system recapitulates essential components of the genetically defined ATR-signaling pathway.
[ePub] GUIA ESENCIAL DE REHABILITACION INFANTIL descargar gratis
Creators: name: Haun
Publisher: name: Zenodo
Year: 2024

description: GUIA ESENCIAL DE REHABILITACION INFANTIL de

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GUIA ESENCIAL DE REHABILITACION INFANTIL

 

Número de páginas: 338

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788491106180

Editorial: PANAMERICANA

Año de edición: 2019

 

 

 

 

 

Descargar kindle books gratis android GUIA ESENCIAL DE REHABILITACION INFANTIL 9788491106180 de PDB

 

Overview

El actual modelo de Unidades de Rehabilitación Infantil se forma tomando como punto de partida las tradicionales secciones de parálisis cerebral, integradas en los Centros Base dentro de las unidades de rehabilitación osteomuscular infantil y de la función valoradora, con el fin de proporcionar asistencia a niños y adolescentes de 0 a 16 años. Con una cartera de servicios muy amplia, entre los que destaca la prevención y valoración de todas las patologías subsidiarias de generar discapacidad en la infancia tanto de naturaleza neurológica, ortopédica, respiratoria o de la comunicación, ofrecen tratamiento con herramientas propias de la medicina física y rehabilitación (fisioterapia, terapia ocupacional y logopedia), ortesis y ayudas técnicas, o comunes con otras disciplinas, como el uso de toxina botulínica. Este manual es de utilidad para pediatras, obstetras y especialidades quirúrgicas infantiles que convengan en una derivación más eficiente del paciente y en un trabajo terapéutico consensuado.
TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition
Creators: name: Lei, Qun Ying
name: Guan, Kun Liang
name: Zhang, Heng
name: Zhao, Bin
name: Xiong, Yue
name: Yao, Jun
name: Liu, Chen Ying
name: Zhao, Shimin
name: Zha, Zheng Yu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The TAZ transcription co-activator has been shown to promote cell proliferation and to induce epithelial-mesenchymal transition. Recently we have demonstrated that TAZ is phosphorylated and inhibited by the Hippo tumor suppressor pathway, which is altered in human cancer. The mechanism of TAZ-mediated transcription is unclear. We demonstrate here that TEAD is a key downstream transcription factor mediating the function of TAZ. Disruption of TEAD-TAZ binding or silencing of TEAD expression blocked the function of TAZ to promote cell proliferation and to induce epithelial-mesenchymal transition, demonstrating TEAD as a key downstream effector of TAZ. We also identified CTGF, a gene that regulates cell adhesion, proliferation, and migration, as a direct target of TAZ and TEAD. Our study establishes a functional partnership between TAZ and TEAD under negative regulation by the Hippo signaling pathway.
(3162) Arthur Noel Edwards
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The January 2015 outburst of a red nova in M31
Creators: name: Kurtenkov, Alexander
name: Pessev, Peter
name: Tomov, Toma
name: Barsukova, Elena A.
name: Fabrika, Sergei
name: Vida, Krisztián
name: Hornoch, Kamil
name: Ovcharov, Evgeni P.
name: Goranskij, Vitaly P.
name: Valeev, Azamat F.
name: Molnár, László
name: Sárneczky, Krisztián
name: Kostov, Andon
name: Nedialkov, Petko
name: Valenti, Stefano
name: Geier, Stefan
name: Wiersema, Klaas
name: Henze, Martin
name: Shafter, Allen W.
name: Dimitrova, Rosa Victoria Muñoz
name: Popov, Vasil N.
name: Stritzinger, Maximilian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: M31N 2015-01a (or M31LRN 2015) is a red nova that erupted in January 2015 -- the first event of this kind observed in M31 since 1988. Very few similar events have been confirmed as of 2015. Most of them are considered to be products of stellar mergers. Results of an extensive optical monitoring of the transient in the period January-March 2015 are presented. Eight optical telescopes were used for imaging. Spectra were obtained on BTA, GTC and the Rozhen 2m telescope. We present a highly accurate 70 d lightcurve and astrometry with a 0.05" uncertainty. The color indices reached a minimum 2-3 d before peak brightness and rapidly increased afterwards. The spectral type changed from F5I to F0I in 6 d before the maximum and then to K3I in the next 30 d. The luminosity of the transient was estimated to $8.7^{+3.3}_{-2.2}\times10^{5}L_{\odot}$ during the optical maximum. Both the photometric and the spectroscopic results confirm that the object is a red nova, similar to V838 Monocerotis.
description: 5 pages, 4 figures, 4 tables, accepted for publication in Astronomy and Astrophysics as a Letter to the Editor; page 5 is online material only
Electronic supplementary information from Odours from marine plastic debris induce food search behaviours in a forage fish
Creators: name: Savoca, Matthew S.
name: Tyson, Chris W.
name: McGill, Michael
name: Slager, Christina J.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Plastic pollution is an anthropogenic stressor in marine ecosystems globally. Many species of marine fish (more than 50) ingest plastic debris. Ingested plastic has a variety of lethal and sublethal impacts and can be a route for bioaccumulation of toxic compounds throughout the food web. Despite its pervasiveness and severity, our mechanistic understanding of this maladaptive foraging behaviour is incomplete. Recent evidence suggests that the chemical signature of plastic debris may explain why certain species are predisposed to mistaking plastic for food. Anchovy (Engraulis sp.) are abundant forage fish in coastal upwelling systems and a critical prey resource for top predators. Anchovy ingest plastic in natural conditions, though the mechanism they use to misidentify plastic as prey is unknown. Here, we presented wild-caught schools of Northern Anchovy (Engraulis mordax) with odour solutions made of plastic debris and clean plastic to compare school-wide aggregation and rheotactic responses relative to food and food odour presentations. Anchovy schools responded to plastic debris odour with increased aggregation and reduced rheotaxis. These results were similar to the effects food and food odour presentations had on schools. Conversely, these behavioural responses were absent in clean plastic and control treatments. To our knowledge, this is the first experimental evidence that adult anchovy use odours to forage. We conclude that the chemical signature plastic debris acquires in the photic zone can induce foraging behaviours in anchovy schools. These findings provide further support for a chemosensory mechanism underlying plastic consumption by marine wildlife. Given the trophic position of forage fish, these findings have considerable implications for aquatic food webs and possibly human health.
Fermi-GBM Observation of GRB 090717034: $χ^2$ Test Confirms Evidence of Gravitational Lensing by a Supermassive Black Hole with Million Solar Mass
Creators: name: Kalantari, Zeinab
name: Rahvar, Sohrab
name: Ibrahim, Alaa
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Gravitational lensing of gamma-ray bursts (GRBs) can provide an opportunity to probe the massive compact objects in the universe at different redshifts. We have discovered two consecutive pulses in the light curve of GRB 090717034, with the same temporal profile and different count rate, separated by a time interval, which is identified as gravitationally lensed candidate in Fermi/GBM GRB catalogue \citep{Kalantari}. Here, we use the $χ^2$ method to investigate the similarity of the temporal profile variability of the two pulses as a gravitationally lensed candidate GRB. We find the magnification factor and the time delay between two pulses to correspond to minimising the $χ^2$ function. Then, we perform a Monte Carlo simulation on a sample of mock lensed GRBs and compare the $χ^2$ of the lensed GRB candidate with the simulation, which confirms this candidate with $1σ$ confidence level. Assuming that GRB 090717034 is lensed by a point-like object, the redshifted lens mass is about $M_L(1+z)=(4.220\pm 6.615) \times 10^6 M_{\odot}$. The lens of this GRB is a candidate for a super-massive black hole along the line of sight to the GRB.
Drosophila melanogaster Myosin-18 Represents a Highly Divergent Motor with Actin Tethering Properties
Creators: name: Sellers, James R.
name: Guzik-Lendrum, Stephanie
name: Takagi, Yasuharu
name: Houdusse, Anne
name: Nagy, Attila
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The gene encoding Drosophila myosin-18 is complex and can potentially yield six alternatively spliced mRNAs. One of the major features of this myosin is an N-terminal PDZ domain that is included in some of the predicted alternatively spliced products. To explore the biochemical properties of this protein, we engineered two minimal motor domain (MMD)-like constructs, one that contains the N-terminal PDZ (myosin-18 M-PDZ) domain and one that does not (myosin-18 M-ΔPDZ). These two constructs were expressed in the baculovirus/Sf9 system. The results suggest that Drosophila myosin-18 is highly divergent from most other myosins in the superfamily. Neither of the MMD constructs had an actin-activated MgATPase activity, nor did they even bind ATP. Both myosin-18 M-PDZ and M-ΔPDZ proteins bound to actin with Kd values of 2.61 and 1.04 μm, respectively, but only about 50–75% of the protein bound to actin even at high actin concentrations. Unbound proteins from these actin binding assays reiterated the 60% saturation maximum, suggesting an equilibrium between actin-binding and non-actin-binding conformations of Drosophila myosin-18 in vitro. Neither the binding affinity nor the substoichiometric binding was significantly affected by ATP. Optical trapping of single molecules in three-bead assays showed short lived interactions of the myosin-18 motors with actin filaments. Combined, these data suggest that this highly divergent motor may function as an actin tethering protein.
Laser operation and Bose-Einstein condensation: analogies and differences
Creators: name: Chiocchetta, Alessio
name: Gambassi, Andrea
name: Carusotto, Iacopo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: After reviewing the interpretation of laser operation as a non-equilibrium Bose-Einstein condensation phase transition, we illustrate the novel features arising from the non-equilibrium nature of photon and polariton Bose-Einstein condensates recently observed in experiments. We then proposea quantitative criterion to experimentally assess the equilibrium vs. non-equilibrium nature of a specific condensation process, based on fluctuation-dissipation relations. The power of this criterion is illustrated on two models which shows very different behaviours.
The Src Family Kinases and Protein Kinase C Synergize to Mediate G q -dependent Platelet Activation
Creators: name: Stefanini, Lucia
name: Bergmeier, Wolfgang
name: Whiteheart, Sidney W.
name: Zhang, Guoying
name: Li, Zhenyu
name: Gartner, T. Kent
name: Xiang, Binggang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The Src family kinases (SFKs) play essential roles in collagen- and von Willebrand factor (VWF)-mediated platelet activation. However, the roles of SFKs in G protein-coupled receptor-mediated platelet activation and the molecular mechanisms whereby SFKs are activated by G protein-coupled receptor stimulation are not fully understood. Here we show that the thrombin receptor protease-activated receptor 4 agonist peptide AYPGKF elicited SFK phosphorylation in P2Y12 deficient platelets but stimulated minimal SFK phosphorylation in platelets lacking Gq. We have previously shown that thrombin-induced SFK phosphorylation was inhibited by the calcium chelator 5,5′-dimethyl-bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (dimethyl-BAPTA). The calcium ionophore A23187 induced SFK phosphorylation in both wild-type and Gq deficient platelets. Together, these results indicate that SFK phosphorylation in response to thrombin receptor stimulation is downstream from Gq/Ca2+ signaling. Moreover, {"type":"entrez-nucleotide","attrs":{"text":"A23187","term_id":"833253","term_text":"A23187"}}A23187-induced thromboxane A2 synthesis, platelet aggregation, and secretion were inhibited by preincubation of platelets with a selective SFK inhibitor, PP2. AYPGKF-induced thromboxane A2 production in wild-type and P2Y12 deficient platelets was abolished by PP2, and AYPGKF-mediated P-selectin expression, integrin αIIbβ3 activation, and aggregation of P2Y12 deficient platelets were partially inhibited by the PKC inhibitor Ro-31-8220, PP2, dimethyl-BAPTA, or LY294002, but were abolished by Ro-31-8220 plus PP2, dimethyl-BAPTA, or LY294002. These data indicate that Ca2+/SFKs/PI3K and PKC represent two alternative signaling pathways mediating Gq-dependent platelet activation.
Diminished Acyl-CoA Synthetase Isoform 4 Activity in INS 832/13 Cells Reduces Cellular Epoxyeicosatrienoic Acid Levels and Results in Impaired Glucose-stimulated Insulin Secretion
Creators: name: Klett, Eric L.
name: Zeldin, Darryl C.
name: Edin, Matthew L.
name: Newgard, Christopher B.
name: Ilkayeva, Olga
name: Chen, Shufen
name: Coleman, Rosalind A.
name: Li, Lei O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Glucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells is potentiated by fatty acids (FA). The initial step in the metabolism of intracellular FA is the conversion to acyl-CoA by long chain acyl-CoA synthetases (Acsls). Because the predominantly expressed Acsl isoforms in INS 832/13 cells are Acsl4 and -5, we characterized the role of these Acsls in beta-cell function by using siRNA to knock down Acsl4 or Acsl5. Compared with control cells, an 80% suppression of Acsl4 decreased GSIS and FA-potentiated GSIS by 32 and 54%, respectively. Knockdown of Acsl5 did not alter GSIS. Acsl4 knockdown did not alter FA oxidation or long chain acyl-CoA levels. With Acsl4 knockdown, incubation with 17 mm glucose increased media epoxyeicosatrienoic acids (EETs) and reduced cell membrane levels of EETs. Further, exogenous EETs reduced GSIS in INS 832/13 cells, and in Acsl4 knockdown cells, an EET receptor antagonist partially rescued GSIS. These results strongly suggest that Acsl4 activates EETs to form EET-CoAs that are incorporated into glycerophospholipids, thereby sequestering EETs. Exposing INS 832/13 cells to arachidonate or linoleate reduced Acsl4 mRNA and protein expression and reduced GSIS. These data indicate that Acsl4 modulates GSIS by regulating the levels of unesterified EETs and that arachidonate controls the expression of its activator Acsl4.
Read online: Le code de la route Rousseau
Creators: name: Smith
Publisher: name: Zenodo
Year: 2024

description: Le code de la route Rousseau pan Codes Rousseau

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Caractéristiques

Le code de la route Rousseau

Codes Rousseau

Nb. de pages: 239

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782709514637

Editeur: Codes Rousseau

Date de parution: 2018

 

 

 

Télécharger un ebook pdf en ligne Le code de la route Rousseau

 

Overview

Clair et synthétique, le Code de la route Rousseau permet de se préparer au permis de conduire dans les meilleures conditions. Conçue par des professionnels de la formation à la conduite, cette nouvelle édition est entièrement réorganisée pour travailler efficacement les 10 thèmes de la nouvelle épreuve. Elle propose : une explication détaillée des 10 nouveaux thèmes articulés autour des 9 familles qui composent désormais la nouvelle épreuve théorique ; 2 pages pour chaque sujet, avec 2 modes de lecture possibles : l'essentiel dans les encadrés de couleur, les informations complémentaires dans le corps du texte ; de nombreux schémas et illustrations explicatifs ainsi que l'intégralité des panneaux de signalisation en fin d'ouvrage ; un index précis avec des mots-clés clairement identifiés pour faciliter les recherches. Cette nouvelle édition est interactive avec 10 QR Codes pour comprendre en vidéo les notions difficiles. Pour une préparation intensive à la nouvelle épreuve, le Code de la route Rousseau contient un code d'accès individuel au site Exatest qui propose 400 questions à jour de la réforme avec : une révision classique ou thématique ; des réponses corrigées et commentées ; un suivi de sa progression.
Magnetic Phases of Frustrated Ferromagnetic Spin-Trimer System Gd_3_Ru_4_Al_12_ With a Distorted Kagome Lattice Structure
Creators: name: Nakamura, S.
name: Kabeya, N.
name: Kobayashi, M.
name: Araki, K.
name: Katoh, K.
name: Ochiai, A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The magnetization and specific heat measurements have been performed on single-crystalline Gd_3_Ru_4_Al_12_ with a distorted Kagome lattice structure. This spin system is regarded as an antiferromagnetic triangular lattice of XY like Heisenberg model at low temperatures. The magnetic phase diagrams indicate the existence of frustration and Z_2_ degeneracy. The magnetization and specific heat imply the successive phase transitions with partial disorder and a T-shaped spin structure in the ground state.
description: 14 pages, 19 figures
[Kindle] TRAICIÓN EN PALACIO descargar gratis
Creators: name: Bates
Publisher: name: Zenodo
Year: 2024

description: TRAICIÓN EN PALACIO de HERNAN GOMEZ BRUERA

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Ficha técnica

TRAICIÓN EN PALACIO

HERNAN GOMEZ BRUERA

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9786073834162

Editorial: GRIJALBO

 

 

 

 

 

Descarga de libros electrónicos de texto TRAICIÓN EN PALACIO en español 9786073834162 PDB de HERNAN GOMEZ BRUERA

 

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Antes de finalizar el tercer año de su gobierno, Andrés Manuel López Obrador apartó de su equipo disfrazando el hecho como una salida amistosa a Julio Scherer Ibarra, uno de sus hombres de mayor confianza, e hijo de uno de los periodistas más reconocidos en la historia reciente de México.Nunca se explicaron los verdaderos motivos, y este hecho tampoco tuvo la resonancia que merecía, pese a que quien se iba era, quizá, el segundo hombre más poderoso del país en ese momento.A partir de una acuciosa investigación, Hernán Gómez Bruera-analista político, periodista y entrevistador- detalla que detrás de esa salida se escondía un historial de traición, tanto a la memoria de su padre como a la narrativa central del movimiento político que lo llevó al poder: erradicar la corrupción y separar el poder económico del poder político.Traición en Palacio es, por un lado, la historia del todopoderoso exconsejero jurídico que aprovechó su posición privilegiada en el gobierno para controlarbuena parte del sistema de justicia en México. Y por el otro, una denuncia de los mecanismos de corrupción en el Poder Judicial con los que se fabricanculpables y se vende impunidad; una detallada descripción de un modus operandi que la 4T no ha logrado erradicar.