Additional file 1 of Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level
Creators: name: Dussiau, Charles
name: Boussaroque, Agathe
name: Gaillard, Mathilde
name: Bravetti, Clotilde
name: Zaroili, Laila
name: Knosp, Camille
name: Friedrich, Chloé
name: Asquier, Philippe
name: Willems, Lise
name: Quint, Laurent
name: Bouscary, Didier
name: Fontenay, Michaela
name: Espinasse, Thibault
name: Plesa, Adriana
name: Sujobert, Pierre
name: Gandrillon, Olivier
name: Kosmider, Olivier
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. Single cell transcriptomic landscape of healthy human bone marrow (HBM1). Fig. S2. Strategy used to represent the evolution of cell-to-cell gene expression variability during differentiation. Fig. S3. Evolution of cell-to-cell gene expression variability during the main pathways of normal hematopoietic differentiation (HBM2). Fig. S4. Test of different size for the sliding window. Fig. S5. Strategy used to calculate delta-entropy and delta-expression. Fig. S6. Most delta-entropic and most delta-expressed genes along hematopoietic differentiation (HBM1). Fig. S7. delta-entropic and delta-expressed genes along hematopoietic differentiation (HBM2). Fig. S8. Most delta-entropic and most delta-expressed genes along hematopoietic differentiation (HBM2). Fig. S9. Cell-to-cell gene expression variability of transcription factors belonging to the 1000 most delta entropic genes during Erythropoiesis (HBM1). Fig. S10. Cell-to-cell gene expression variability of transcription factors belonging to the 1000 most delta entropic genes during Granulopoiesis (HBM1). Fig. S11. Cell-to-cell gene expression variability of transcription factors belonging to the 1000 most delta entropic genes during dendritic differentiation (HBM1). Fig. S12. Cell-to-cell gene expression variability of transcription factors belonging to the 1000 most delta entropic genes during B lymphopoiesis (HBM1). Fig. S13. Transcriptional landscape of the HSPC compartment of SF3B1 mutated MDS and healthy elderly subjects. Fig. S14. Expression values of selected marker genes for all cell sub-populations of the HSPC compartment of SF3B1 mutated MDS and healthy elderly subjects. Fig. S15. Evolution of cell-to-cell gene expression variability during granulopoiesis in elderly subjects and SF3B1-mutated MDS. Fig. S16. Evolution of cell-to-cell gene expression variability during dendritic differentiation in elderly subjects and SF3B1-mutated MDS. Fig. S17. Evolution of cell-to-cell gene expression variability during B lymphopoiesis in elderly subjects and SF3B1-mutated MDS. Fig. S18. Evolution of cell-to-cell gene expression variability during Erythropoiesis in elderly subjects and SF3B1-mutated MDS. Fig. S19. Comparison of the 100 most delta entropic genes along hematopoietic differentiation between MDS patients and age-matched healthy subjects. Table S1. Distribution of cellular subpopulations for each differentiation pathway in HBM1 and HBM2 dataset. Table S2. Clinico-biological features of patients from whom HSPCs were harvested for the scRNA-seq experiment. Table S3. Distribution of cellular subpopulations for each differentiation pathway in Ctrl1, Ctrl3, MDS2 and MDS4 samples. Table S4. Common delta-entropic genes between MDS patients and age-matched healthy subjects during the different hematopoietic differentiation pathways.