cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5 of Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model
Creators: name: Elsasser, Ted H.
name: Ma, Bing
name: Ravel, Jacques
name: Kahl, Stanislaw
name: Gajer, Pawel
name: Cross, Alan
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5. Table S1: Summary of the identified plant-derived xenobiotic compounds in digests of the duodenum, ileum and cecum. Data illustrate the nature of the changes in presence/detention and relative levels of xenobiotic plant-derived compounds in the relevant digesta as affected by diet. Digesta from chickens fed BC was more complex with more compounds present in the ileal digesta.
Composition and structure of Pd nanoclusters in SiO$_x$ thin film
Creators: name: Thøgersen, Annett
name: Mayandi, Jeyanthinath
name: Vines, Lasse
name: Sunding, Martin F.
name: Olsen, Arne
name: Diplas, Spyros
name: Mitome, Masanori
name: Bando, Yoshio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The nucleation, distribution, composition and structure of Pd nanocrystals in SiO$_2$ multilayers containing Ge, Si, and Pd are studied using High Resolution Transmission Electron Microscopy (HRTEM) and X-ray Photoelectron Spectroscopy (XPS), before and after heat treatment. The Pd nanocrystals in the as deposited sample seem to be capped by a layer of PdO$_x$. A 1-2 eV shift in binding energy was found for the Pd-3d XPS peak, due to initial state Pd to O charge transfer in this layer. The heat treatment results in a decomposition of PdO and Pd into pure Pd nanocrystals and SiO$_2$.
title: Стимулирование педагогов к непрерывному образованию
Creators: name: Медник, Елена
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В монографии на основе результатов концептуально-методологического анализа процесса стимулирования педагогов к непрерывному образованию в процессе внутришкольной методической работы определяются ключевые понятия: непрерывное педагогическое образование, стимулирование педагогов к непрерывному образованию, внутришкольная методическая работа, профессионально-личностная активность педагогов, обучающаяся организация.
В монографии также представлена реализация структурно-функциональной модели, которая осуществлялась в одной из муниципальных автономных общеобразовательных организаций Великого Новгорода. Важным является представленный практико-ориентированный материал, способствующий обеспечению методической поддержки педагогов в области их профессионального роста (педагогической карьеры), повышения педагогического мастерства и квалификации.
Монография адресована преподавателям, научным работникам, студентам и аспирантам.
title: Η επίδραση της πίεσης στην αποδοτικότητα βιολογικών και χημικών μέσων διασποράς
title: Effect of pressure on the efficiency of biological and chemical dispersants
Creators: name: Κοκολακης Πετρος
Publisher: name: Technical University of Crete
Year: 2019

description: Τα πετρελαϊκά προϊόντα παράγονται και καταναλώνονται παγκοσμίως όλο και περισσότερο ενώ αυξάνονται οι περιβαλλοντικές επιπτώσεις. Παρά τα μέτρα πρόληψης, παραμένει ο κίνδυνος σημαντικών διαρροών πετρελαίου. Η χημική σύνθεση, οι ιδιότητες του διαφεύγοντος πετρελαίου και οι συναφείς αντιδράσεις που οφείλονται στις καιρικές συνθήκες, διέπουν τη μοίρα, τη συμπεριφορά και την επίδρασή τους στα θαλάσσια περιβάλλοντα. Οι πετρελαιοκηλίδες προκαλούν μεγάλη ανησυχία λόγω της μακροπρόθεσμης σημαντικής βλάβης των θαλάσσιων οικοσυστημάτων. Στην παρούσα διπλωματική εξετάζεται η αποτελεσματικότητα τεσσάρων διασκορπιστικών ουσιών στη διαλυτοποίηση του πετρελαίου αρχικά σε ατμοσφαιρική πίεση όπως ορίζει το πρωτόκολλο της Υπηρεσίας Προστασίας του Περιβάλλοντος της Αμερικής (EPA) και ακολούθως σε συνθήκες πίεσης 25, 50, 75, 100 bar, προσαρμόζοντας το πρωτόκολλο της EPA με χρήση αντιδραστήρα υψηλής πίεσης. Στόχος αυτής της διερεύνησης, είναι να προσδιοριστεί κατά πόσο αποτελεσματικά δρουν οι τασιενεργές ουσίες σε περιβάλλον υποθαλάσσιας πίεσης. Με βάση τα αποτελέσματα της αποδοτικότητας των ουσιών στη διαλυτοποίηση του πετρελαίου που θα προκύψουν θα αξιολογηθούν ως προς τα πλεονεκτήματα που εμφανίζουν.
description: Petroleum products are increasingly being produced and consumed worldwide, while environmental impacts are increasing. Despite the precautionary measures, there is the risk of significant oil spills. The chemical composition, the properties of escaping oil and the associated weather-related reactions govern their fate, behavior and impact on marine environments. Oil spills are a cause of great concern due to the long-term significant damage to marine ecosystems. This diploma thesis examines the effectiveness of four dispersants in oil dispersion initially at atmospheric pressure as defined by the EPA protocol and subsequently under pressure conditions of 25, 50, 75, 100 bar, adapting the EPA protocol using a high pressure reactor. The purpose of this investigation is to determine the effectiveness of surfactants in an underwater pressure environment. Based on the results of the efficiency of the oil dispersing substances that will emerge, they will be evaluated for the advantages they present.
Interference-Based Cell Selection in Heterogenous Networks
Creators: name: Davaslioglu, Kemal
name: Ayanoglu, Ender
Publisher: name: arXiv
Year: 2013
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Heterogeneous cellular networks provide significant improvements in terms of increased data rates and cell coverage, and offer reduced user rate starvation. However, there are important problems to be solved. In this paper, we identify that the cell selection criterion is an important factor determining the user rates especially in the uplink transmissions and apply cell breathing to determine the user and base station assignments. We observe that the proposed interference-based cell selection algorithm provides better load balancing among the base stations in the system to improve the uplink user rates. We present the implementation steps in a typical LTE network and demonstrate the performance improvements through simulations.
title: Το ηλεκτρονικό εμπόριο ως καινοτόμο εργαλείο επιχειρηματικής δραστηριότητας και ανάπτυξη εφαρμογής σε ελληνική εταιρεία κατασκευής ηλεκτροκινητήρων
Creators: name: Βαλιάδης Φοίβος
Publisher: name: Technical University of Crete
Year: 2001

description: Μη διαθέσιμο
title: Ανάλυση αντοχής και ευστάθειας του δεξαμενόπλοιου "Μπόου Πρόσπερ" με το πρόγραμμα ANKO Marine Load Planner
Creators: name: Ψαρρός Μιχάλης
Publisher: name: Technical University of Crete
Year: 2001

description: Μη διαθέσιμο
Molecular methods for the detection of infectious diseases: bringing diagnostics to the point-of-care
Creators: name: Malpartida Cardenas, Kenny Shannen
Publisher: name: Imperial College London
Year: 2021

description: Human infectious diseases represent a leading cause of morbidity and mortality globally, caused by human-infective pathogens such as bacteria, viruses, parasites or fungi. Point-of-care (POC) diagnostics allow accessible, simple, and rapid identification of the organism causing the infection which is crucial for successful prognostic outcomes, clinical management, surveillance and isolation. The research conducted in this thesis aims to investigate novel methods for molecular-based diagnostics. This multidisciplinary project is divided into three main sections: (i) molecular methods for enhanced nucleic acid amplification, (ii) POC technologies, and (iii) sample preparation. The application, design and optimisation of loop-mediated isothermal amplification (LAMP) is investigated from a molecular perspective for the diagnostics of emerging infectious pathogens and antimicrobial resistance. LAMP assays were designed to target pathogens responsible for parasitic (malaria), bacterial and viral (COVID-19) infections, as well as antimicrobial resistance. A novel LAMP-based method for the detection of single nucleotide polymorphisms was developed and applied for diagnostics of antimicrobial resistance, emerging variants and genetic disorders. The method was validated for the detection of artemisinin-resistant malaria. Furthermore, this thesis reports the optimisation of LAMP from a biochemical perspective through the evaluation of its core reagents and the incorporation of enhancing agents to improve its specificity and sensitivity. In order to remove cold-chain storage from the diagnostic workflow, the optimised LAMP protocol was designed to be compatible with lyophilisation. Translation of LAMP to the POC demands the development of detection technologies that are compatible with the advantages offered by isothermal amplification. The use of simple, accessible and portable technologies is investigated in this thesis through the development of: (i) a novel colorimetricLAMP detection method for end-point and low cost detection, and (ii) the combination of LAMP with an electrochemical biosensing platform based on ion-sensitive field effect transistors (ISFETs) fabricated in unmodified complementary metal-oxide semiconductor (CMOS) technology for real-time detection. Lastly, current nucleic acid extraction methods are not transferable to be used outside the laboratory. Research of novel methods for low-cost and electricity-free sample preparation was carried out using cellulose matrices. A novel, rapid (under 10 min) and efficient nucleic acid extraction method from dried blood spots was developed. A sample-to-result POC test requires the implementation and integration of molecular biology, cutting-edge technology and data-driven approaches. The work presented in this thesis aims to set new benchmarks for the detection of infectious diseases at the POC by leveraging on developments in molecular biology and digital technologies.
Integrated and joint optimisation of runway-taxiway-apron operations on airport surface
Creators: name: Yin, Suwan
Publisher: name: Imperial College London
Year: 2021

description: Airports are the main bottlenecks in the Air Traffic Management (ATM) system. The predicted 84% increase in global air traffic in the next two decades has rendered the improvement of airport operational efficiency a key issue in ATM. Although the operations on runways, taxiways, and aprons are highly interconnected and interdependent, the current practice is not integrated and piecemeal, and overly relies on the experience of air traffic controllers and stand allocators to manage operations, which has resulted in sub-optimal performance of the airport surface in terms of operational efficiency, capacity, and safety. This thesis proposes a mixed qualitative-quantitative methodology for integrated and joint optimisation of runways, taxiways, and aprons, aiming to improve the efficiency of airport surface operations by integrating the operations of all three resources and optimising their coordination. This is achieved through a two-stage optimisation procedure: (1) the Integrated Apron and Runway Assignment (IARA) model, which optimises the apron and runway allocations for individual aircraft on a pre-tactical level, and (2) the Integrated Dynamic Routing and Off-block (IDRO) model, which generates taxiing routes and off-block timing decisions for aircraft on an operational (real-time) level. This two-stage procedure considers the interdependencies of the operations of different airport resources, detailed network configurations, air traffic flow characteristics, and operational rules and constraints. The proposed framework is implemented and assessed in a case study at Beijing Capital International Airport. Compared to the current operations, the proposed apron-runway assignment reduces total taxiing distance, average taxiing time, taxiing conflicts, runway queuing time and fuel consumption respectively by 15.5%, 15.28%, 45.1%, [58.7%, 35.3%, 16%] (RWY01, RWY36R, RWY36L) and 6.6%; gated assignment is increased by 11.8%. The operational feasibility of this proposed framework is further validated qualitatively by subject matter experts (SMEs). The potential impact of the integrated apron-runway-taxiway operation is explored with a discussion of its real-world implementation issues and recommendations for industrial and academic practice.
title: Εκτίμηση της δανειοληπτικής ικανότητας χωρών με χρήση της πολυκριτήριας μεθόδου M.H.DIS
Creators: name: Πολλάτου Ειρήνη
Publisher: name: Technical University of Crete
Year: 2001

description: Μη διαθέσιμο
Magmatic controls on porphyry copper deposit formation and machine learning approaches for mineral exploration
Creators: name: Nathwani, Chetan Lalitkumar
Publisher: name: Imperial College London
Year: 2022

description: Porphyry copper deposits are a rare manifestation of arc magmatism, occurring in restricted spatiotemporal windows within magmatic arcs. Many of the largest deposits are related to the optimal alignment of tectono-magmatic processes, and this magmatic history can be recorded in the geochemistry of related rocks and minerals. The first half of this thesis documents the magmatic evolution of the Quellaveco District, Southern Peru, where 12 Myr of magmatism is recorded by incremental batholith construction and multi-centred porphyry Cu-Mo deposit emplacement. Whole-rock geochemistry and zircon petrochronology record a deepening locus of lower crustal magmatic evolution ca. 2 Myr prior to mineralisation. This delay allowed a sufficiently large volume of hydrous magma to accumulate in the deep crust which was rapidly transferred to the upper crust to form giant porphyry Cu-Mo deposits. Numerical modelling of zircon Eu anomalies reveals that the characteristically suppressed Eu anomaly of zircons from porphyry copper deposits is predominantly caused by inheriting the melt compositional signature of amphibole-dominated and plagioclase-suppressed fractionation. Apatite inclusions in zircon from these rocks indicates that the Quellaveco magmatic system was fluid saturated for the duration of porphyry Cu mineralisation. Numerical modelling suggests that the system was held at high crystallinity over this period which promoted saturation of highly saline and copper-charged instantaneous fluids. The second half of this thesis highlights value of using machine learning algorithms to aid geochemical exploration for porphyry Cu deposits. Predicting magma fertility using geochemistry and supervised learning provides a significant improvement over more traditional bivariate methods such as Sr/Y ratios or zircon Eu anomalies. Deep learning can be used to recognise and classify the strongly oscillatory zoned euhedral zircon crystals associated with porphyry deposits. Overall, these methods are effective in discriminating porphyry Cu fertility but are mostly ineffective at indicating the size or type of porphyry deposit.
On the least number of palindromes contained in an infinite word
Creators: name: Fici, Gabriele
name: Zamboni, Luca Q.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Formal Languages and Automata Theory (cs.FL)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 68R15

description: We investigate the least number of palindromic factors in an infinite word. We first consider general alphabets, and give answers to this problem for periodic and non-periodic words, closed or not under reversal of factors. We then investigate the same problem when the alphabet has size two.
description: Accepted for publication in Theoretical Computer Science
Marcus Tullius Cicero, Pro Archia poeta. Verteidigung für den Dichter Archias. Übersetzt, hg. und mit einem Essay von Carsten Schmieder
Creators: name: Maaz, Wolfgang
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Marcus Tullius Cicero, Pro Archia poeta. Verteidigung für den Dichter Archias. Übersetzt, hg. und mit einem Essay von Carsten Schmieder. Berlin 2010. Hybris. 98 S. (ISBN 978-3- 939735-02-1).
description: Forum Classicum, Nr. 1 (2014): Forum Classicum
Sistema y método de transmisión de datos entre una unidad móvil y una unidad receptora.
Creators: name: Gázquez, José A.
name: Novas, Nuria
name: Berenguel Soria, Manuel
name: Lorente Acosta, Manuel
name: Noguerol Gutiérrez, Marina
Publisher: name: Zenodo
Year: 2007

description: Sistema y método de transmisión de datos entre una unidad móvil y una unidad receptora.La invención se refiere a un método y sistema para transmitir datos entre una unidad móvil (1) y una unidad receptora (2), a través de una red (3) asociada a nodos derepetición (31) que reciben los datos, en forma de paquetes, desde la unidad móvil y los transmiten hasta la unidadreceptora (2), que está configurada para descartar paquetes que se reciben de forma repetida, mediante el controlde un identificador único asociado a cada paquete.Para mayor seguridad en cuanto a cobertura, se puedecompletar la posibilidad de transmisión vía los nodos derepetición con una forma alternativa de transmitir los datos, por ejemplo, vía GPRS.
description: Sistema y método de transmisión de datos entre una unidad móvil y una unidad receptora.La invención se refiere a un método y sistema para transmitir datos entre una unidad móvil (1) y una unidad receptora (2), a través de una red (3) asociada a nodos derepetición (31) que reciben los datos, en forma de paquetes, desde la unidad móvil y los transmiten hasta la unidadreceptora (2), que está configurada para descartar paquetes que se reciben de forma repetida, mediante el controlde un identificador único asociado a cada paquete.Para mayor seguridad en cuanto a cobertura, se puedecompletar la posibilidad de transmisión vía los nodos derepetición con una forma alternativa de transmitir los datos, por ejemplo, vía GPRS.
Ethnic Differences in Context: Does Emotional Conflict Mediate the Effects of Both Team- and Individual-Level Ethnic Diversity on Emotional Strain?
Creators: name: Kößler, Franziska Josefine
name: Fujishiro, Kaori
name: Veit, Susanne
name: Hoppe, Annekatrin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: Ethnic heterogeneity
subject: Ethnic dissimilarity
subject: Well-being
subject: Status
subject: Relational demography
subject: Social processes
subject: 150 Psychologie

description: Work teams are becoming increasingly heterogeneous with respect to their team members’ ethnic backgrounds. Two lines of research examine ethnic diversity in work teams: The compositional approach views team-level ethnic heterogeneity as a team characteristic, and relational demography views individual-level ethnic dissimilarity as an individual member’s relation to their team. This study compares and contrasts team-level ethnic heterogeneity and individual-level ethnic dissimilarity regarding their effects on impaired well-being (i.e., emotional strain) via team- and individual-level emotional conflict. Fifty teams of retail chain salespeople (n = 602) participated in our survey at two points of measurement. Based on the ethnic background of team members, we calculated team-level ethnic heterogeneity that applied to all members, and individual-level ethnic dissimilarity within the team that varied according to each member’s ethnic background. Multilevel path modeling showed that high levels of team-level ethnic heterogeneity were related to high levels of emotional strain via team-level emotional conflict. However, the opposite was found for individual-level ethnic dissimilarity. We discussed this difference by contextualizing individual-level ethnic dissimilarity in the team-level heterogeneity and social status of ethnic groups in society at large. Our findings suggest that the social status of the ethnic group to which team members belong may impact how ethnic diversity relates to team processes and well-being.
title: Οικονομοτεχνική μελέτη μονάδας αφαλάτωσης με τη χρήση ανανεώσιμων πηγών ενέργειας
Creators: name: Κουνενάκη Μαρία
Publisher: name: Technical University of Crete
Year: 2001

description: Μη διαθέσιμο
Additional file 9 of Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model
Creators: name: Elsasser, Ted H.
name: Ma, Bing
name: Ravel, Jacques
name: Kahl, Stanislaw
name: Gajer, Pawel
name: Cross, Alan
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 9. Supplementary Data 2. Metabolon Analytic Platform.
The Chemistry teaching laboratory: A sensory overload vortex for students and instructors?
Creators: name: Flaherty, Aishling
Publisher: name: University of Limerick
Year: 2022
Subjects: subject: Education
subject: Health sciences
subject: FOS: Health sciences

description: Engaging in laboratory practical activities, developing laboratory practical skills, and, to a degree, even wearing laboratory protective equipment such as safety coats and goggles are all quintessential components of chemistry education. It is becoming quite common for institutions to invest in large-scale chemistry teaching laboratories, filling them with cutting-edge technology, chemicals and apparatus, digital learning tools and laboratory furniture. It is also becoming quite common for educators to develop and execute well considered, research-based approaches to learning and teaching in the laboratory. However, despite such grand and admirable commitments and ambitions, there seems to be little acknowledgment of just how difficult it can be for some to be a room that is so noisy, bright, odorous and surrounded by hazards, risks, chemicals, glassware, electricity, gas, naked flames, eye washes, body showers, fume hoods the list goes on. While sensory overload issues were once associated with psychiatric mental disorders such as Autism, Schizophrenia, and Attention Deficit Hyperactivity Disorder, it is now becoming known that anyone, regardless of whether they have a psychiatric mental disorder, can experience sensory issues for a variety of reasons. As such, while the chemistry teaching laboratory and all its sense-demanding intricacies might be manageable for some, for other students and instructors akin who experience sensory overload issues, it can be a most-unnerving environment to be in, let alone to think about chemical concepts. The purpose of this Article is to review literature on the concept of sensory overload, consider some research on sensory overload, and identify how this may implicate chemistry laboratory education.
Additional file 10 of Short-term feeding of defatted bovine colostrum mitigates inflammation in the gut via changes in metabolites and microbiota in a chicken animal model
Creators: name: Elsasser, Ted H.
name: Ma, Bing
name: Ravel, Jacques
name: Kahl, Stanislaw
name: Gajer, Pawel
name: Cross, Alan
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 10. Reference database obtained using a Boolean construct of the terms: polyphenol, flavonoids, bile acids, amino acids, fatty acids, or oligosaccharides along with small intestine, metabolite, and inflammation. Other relevant references have already been incorporated into the main reference information.
title: Μελέτη σκοπιμότητας χωροθέτησης τουριστικού λιμένα στο Πόρτο Χέλι
Creators: name: Καραγεωργιάδης Αθανάσιος
Publisher: name: Technical University of Crete
Year: 2001

description: Μη διαθέσιμο
Wolfgang Schuller, Cicero oder Der letzte Kampf um die Republik. Eine Biographie
Creators: name: Schmidt, Ernst A.
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Wolfgang Schuller, Cicero oder Der letzte Kampf um die Republik. Eine Biographie, München 2013 (ISBN 978-3406651786).
description: Forum Classicum, Nr. 2 (2014): Forum Classicum
Spin modulation instabilities and phase separation dynamics in trapped two-component Bose condensates
Creators: name: Vidanovic, Ivana
name: van Druten, N. J.
name: Haque, Masudul
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: In the study of trapped two-component Bose gases, a widely used dynamical protocol is to start from the ground state of a one-component condensate and then switch half the atoms into another hyperfine state. The slightly different intra-component and inter-component interactions can then lead to highly nontrivial dynamics. We study and classify the possible subsequent dynamics, over a wide variety of parameters spanned by the trap strength and by the inter- to intra-component interaction ratio. A stability analysis suited to the trapped situation provides us with a framework to explain the various types of dynamics in different regimes.
description: 8 pages, 5 figures
Using measurements and modelling of carbon isotopes for evaluating methane emissions and sources in the UK
Creators: name: Saboya, Eric
Publisher: name: Imperial College London
Year: 2022

description: Atmospheric methane is an important greenhouse gas that is emitted from a diverse range of anthropogenic and natural sources. Quantifying and attributing methane emissions can provide information on the sources that are driving the increases in atmospheric methane concentrations and be used to guide mitigation policies. In this thesis, I use, develop and compare different approaches for attributing specific sources and quantifying emissions of methane in the UK. The work in this thesis uses carbon isotopes of methane and satellite observations of total methane columns (XCH4) from the TROPOSpheric Monitoring Instrument (TROPOMI) between 2018-2020. Urban areas are hotspots of anthropogenic methane emissions, which are emitted from a number of different sources. I use in situ atmospheric methane and d13CH4 measurements made in central London to demonstrate that continuous measurements from a Picarro isotopic analyser can be used for methane source attribution of large pollution events. These measurements indicated a predominance of fossil methane in central London which was found to be underreported in the UK national emissions inventory. The utility of additional isotopic measurements of atmospheric D14CH4 is explored for the UK by developing a CH4-d13CH4-D14CH4 framework and using pseudo-data simulations. Pseudo-data indicate additional isotopic measurements of D14CH4 could improve the UK's methane source apportionment. A first analysis of TROPOMI methane measurements for the UK is also conducted. I conclude that TROPOMI XCH4 retrievals from 2018-2020 are not useful for informing on UK methane emissions and spatial variations due, in part, to the low data availability for the UK over this period. My findings indicate that ground-based atmospheric measurements are more useful for constraining sector specific methane emissions and informing on regional differences than TROPOMI measurements for the UK. Whilst d13CH4 measurements are found to be valuable for source attribution, additional measurements of atmospheric D14CH4 could be used to improve the methane source constraint for the UK.
Single-molecule studies of eukaryotic RNA Polymerase II
Creators: name: Moore, George
Publisher: name: Imperial College London
Year: 2022

description: RNA transcription is the essential first step in the conversion of genetic information stored in DNA into fully functioning proteins. RNA polymerases read this genetic information and make a complimentary form, called RNA. RNA Polymerase II is responsible for read- ing and converting most of the protein coding genes. However, eukaryotic DNA is highly complex and contains multiple roadblocks to transcription including nucleosomes and DNA damage. If these damages are not resolved, mutations can arise causing genome in- stability and also cancers including melanoma and adenocarcinoma. How these roadblocks affect RNAPII on a molecular level has yet to be probed deeply at a single-molecule level due to the dynamic nature of this process. Here, I develop novel single-molecule based assays to directly monitor RNAPII elongation dynamics without the need to genetically modify the polymerase. Using the smFRET based assay I was able to visualise RNAPII elongation on different templates including AT-rich DNA. I showed that AT-rich DNA not only induces premature termination of transcription, but also that severe pausing pre- cedes this step. Addition of different damages into the template also caused destabilising effects on RNAPII to varying amounts. While abasic lesions caused complete stalling of RNAPII, UV-induced damage and 8-Oxo Guanine groups led to more dynamic pausing and backtracking behaviour, with RNAPII bypassing the latter damage. Finally, Rad26, a recovery factor, was shown to promote bypass of oxidative damage by physically block- ing the backtracked state and keeping the polymerase around the site of damage. The assays developed here can be utilised for a variety of purposes where other roadblocks, e.g. nucleosomes, can be inserted readily into the template. Furthermore, the results shown here will be important in increasing our understanding of how DNA damage and other roadblocks interfere with the transcription pathway.
title: Δημιουργία άτλαντα πολιτισμού και περιβάλλοντος για το Ακρωτήρι Χανίων. Χαρτογράφηση των πολιτιστικών χώρων με χρήση Γ.Σ.Π.-G.I.S., νομοθεσία προστασίας τους και προτάσεις ανάδειξής τους
Creators: name: Κυριτσοπούλου Αδαμαντία
Publisher: name: Technical University of Crete
Year: 2013

description: Μη διαθέσιμο
Stochastic modelling and inference for evolution in ageing and infectious diseases
Creators: name: Insalata, Ferdinando
Publisher: name: Imperial College London
Year: 2022

description: Counting processes are an important class of stochastic processes with numerous interdisciplinary applications, including to evolving biological systems. Counting processes can be the basis for forward generative models, which can help develop a mechanistic understanding of a phenomenon, or for inferential methods. In this thesis we develop a bottom-up microscopic model of a phenomenon in mitochondrial biology and ageing. Mitochondria are organelles that possess their own DNA, involved in crucial physiological functions. A typical eukaryotic cell hosts a population of mitochondrial DNA molecules, where mutations can expand and cause dysfunctions. With age, skeletal muscle suffers a reduction in strength and functionality; in mammals, this has been connected to the clonal expansion of mitochondrial deletion mutations. The mechanism driving this phenomenon remains poorly understood despite intense research. We develop a stochastic population dynamics model corresponding to a novel evolutionary mechanism, termed stochastic survival of the densest, and we show that it can account for the expansion of mitochondrial mutations in skeletal muscle through a literature-parameterised model. We predict that a species can invade a system in a wave-like fashion, without having an explicit replicative advantage and even if preferentially eliminated. We establish that this mechanism is driven by the combined effect of stochasticity, differences in carrying capacity (or density) and spatial structure. Part of the work for this thesis coincided with the COVID-19 pandemic. We look at another application of counting processes, modelling data collected within the SIREN study, part of the national response to the pandemic. We estimate parameters of counting processes modelling SARS‑CoV‑2 infection events, that correspond to the reduction in rate of infection associated with COVID-19 vaccination (vaccine effectiveness), with a previous infection, or both (hybrid protection). We highlight short-term vaccine effectiveness that subsequently wanes, and confirm the immune escape of the Omicron variant.
title: Διερεύνηση του γίγνεσθαι του αζώτου και φαινόλων κατά την εφαρμογή υγρών αποβλήτων ελαιουργείου στο έδαφος
Creators: name: Οικονομίδης Δημήτριος
Publisher: name: Technical University of Crete
Year: 2013

description: Μη διαθέσιμο
Spatial and Temporal Sensing Limits of Microtubule Polarization in Neuronal Growth Cones by Intracellular Gradients and Forces
Creators: name: Mahajan, Saurabh
name: Athale, Chaitanya A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Subcellular Processes (q-bio.SC)
subject: Biological Physics (physics.bio-ph)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Neuronal growth cones are the most sensitive amongst eukaryotic cells in responding to directional chemical cues. Although a dynamic microtubule cytoskeleton has been shown to be essential for growth cone turning, the precise nature of coupling of the spatial cue with microtubule polarization is less understood. Here we present a computational model of microtubule polarization in a turning neuronal growth cone (GC). We explore the limits of directional cues in modifying the spatial polarization of microtubules by testing the role of microtubule dynamics, gradients of regulators and retrograde forces along filopodia. We analyze the steady state and transition behavior of microtubules on being presented with a directional stimulus. The model makes novel predictions about the minimal angular spread of the chemical signal at the growth cone and the fastest polarization times. A regulatory reaction-diffusion network based on the cyclic phosphorylation-dephosphorylation of a regulator predicts that the receptor signal magnitude can generate the maximal polarization of microtubules and not feedback loops or amplifications in the network. Using both the phenomenological and network models we have demonstrated some of the physical limits within which the MT polarization system works in turning neuron.
description: 7 figures and supplementary material
title: Δυνατότητα επαναχρησιμοποίησης των εκροών των εγκαταστάσεων επεξεργασίας λυμάτων νήσου Σάμου
Creators: name: Κούστα Ουρανία
Publisher: name: Technical University of Crete
Year: 2013

description: Μη διαθέσιμο
title: Σχεδιασμός & μελέτη μετατροπής υφιστάμενων κατοικιών σε κτίρια μηδενικής ενεργειακής κατανάλωσης
Creators: name: Ιερωνυμάκης Αθανάσιος
Publisher: name: Technical University of Crete
Year: 2013

description: Μη διαθέσιμο
title: Εκτίμηση αερίων εκπομπών σε χώρους αεροδρομίου στην ατμοσφαιρική αέρια ρύπανση
Creators: name: Κλατσιάς Αλέξανδρος
Publisher: name: Technical University of Crete
Year: 2013

description: Μη διαθέσιμο
Linear polarization of submillimetre masers. Tracing magnetic fields with ALMA
Creators: name: Pérez-Sánchez, A. F.
name: Vlemmings, W. H. T.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: (Abridged) The goal of this work is to investigate if SiO, H2O and HCN maser emission within the ALMA frequency range can be detected with observable levels of fractional linear polarization in the regime where the Zeeman frequency (gOmega) is greater than the stimulated emission rate (R) and the decay rate of the molecular state (Gamma). We have used a radiative transfer code to calculate the fractional linear polarization as a function of the emerging brightness temperature for a number of rotational transition of SiO, H2O and HCN which have been observed to display maser emission at submillimetre wavelengths. We assume typical magnetic field strengths measured towards galactic star forming regions and circumstellar envelopes of late-type stars from previous VLBI observations. Since the Landé g-factors have not been reported for the different rotational transitions we have modeled, we performed our calculations assuming conservative values of the Zeeman frequency for the different molecular species. Setting a lower limit for the Zeeman frequency which still satisfies the criteria gOmega>R and gOmega>Gamma, we find fractional polarization levels of up to 13%, 14% and 19% for the higher J transitions analysed for SiO, H2O and HCN, respectively, without considering anisotropic pumping or any other non-Zeeman effect. Such upper limits were calculated assuming a magnetic field oriented perpendicular to the direction of propagation of the maser radiation. According to our results SiO, H2O and HCN maser emission within the ALMA frequency range can be detected with suitable linear polarization to trace the magnetic field structure towards star forming regions and late-type stars, even if the detected polarization has been enhanced by non-Zeeman effects.
description: 9 pages, 5 figures. Accepted for publication in Astronomy and Astrophysics
title: Ανάπτυξη ενός wrapper με την χρήση της τεχνολογίας των web services για τον έλεγχο στατιστικής αποκάλυψης
Creators: name: Φραντζή Μαρία Κ.
Publisher: name: Technical University of Crete
Year: 2007

description: φ. 2: Έλεγχος στατιστικής αποκάλυψης -- Κεφ. 3: Εφαρμογή T-Argus -- Κεφ. 4: Αρχιτεκτονική -- Κεφ. 5: Βάση δεδομένων -- Κεφ. 6: Προδιαγραφές του Web Service δομικού τμήματος -- Κεφ. 7: Σχεδιασμός του client του Web Service δομικού τμήματος (ΒΒ) -- Κεφ. 8: Οδηγός χρήσης εφαρμογής (application's user guide) -- Κεφ. 9: Οδηγός εγκατάστασης και διαμόρφωσης του application server
Additional file 1 of A systematic review of the health effects of yoga for people with mild cognitive impairment and dementia
Creators: name: Karamacoska, Diana
name: Tan, Tiffany
name: Mathersul, Danielle C.
name: Sabag, Angelo
name: de Manincor, Michael
name: Chang, Dennis
name: Steiner-Lim, Genevieve Z.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Example search strategy used to identify articles in PubMed.
Optimization of the production and function of self-amplifying RNA vaccines
Creators: name: Samnuan, Karnyart
Publisher: name: Imperial College London
Year: 2022

description: Recently, RNA-based vaccines have become highly attractive, with proven ability to induce protective immunes responses against COVID-19, matched with their rapid and relatively simple production. Self-amplifying RNA (saRNA) may provide additional advantages due to its ability to: i) self-replicate facilitating exponential antigen expression; ii) induce equivalent protection with lower doses compared to conventional mRNA vaccines; and iii) elicit longer antigen expression in vivo. saRNA is a single stranded RNA derived from a positive strand virus genome such as Alphaviruses, where the structural proteins are replaced by a gene of interest (GOI). In this thesis, we sought to test the hypothesis that saRNA could be improved through directed evolution and/or nucleotide modifications. First, we optimized the production of saRNA through a design of experiment (DoE) approach to produce a maximal RNA yield and validated the improved IVT method on various sizes of RNA. We then used the optimal IVT method to produce saRNA for the optimization of the function of saRNA where we utilized an iterative directed evolution approach in order to evolve the replicase of the saRNA such that mutations would either confer interferon resistance and/or will allow higher antigen expression in cells. We observed no increase in transgene expression; however, we were able to establish a system and understand the parameters needed to support an iterative directed evolution approach. Lastly, we incorporated different modified nucleosides during IVT and determined whether in vitro antigen expression and in vivo immunogenicity could be improved. We found that N1-Methylpseudouridine incorporated saRNA did not enhance antigen expression in vitro. However, 2’-O-Methyl-GTP incorporation significantly enhanced luciferase and green fluorescent protein (eGFP) expression in interferon-competent HELA and THP-1 cells. Most importantly, we observed that 2’-O-Methyl-GTP modified saRNA encoding for influenza HA elicited significantly stronger antibody responses compared to unmodified saRNA in vivo after a prime-boost regimen.
Characterizing heterogeneous dynamics at hydrated electrode surfaces
Creators: name: Willard, Adam P.
name: Limmer, David T.
name: Madden, Paul A.
name: Chandler, David
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In models of Pt 111 and Pt 100 surfaces in water, motions of molecules in the first hydration layer are spatially and temporally correlated. To interpret these collective motions, we apply quantitative measures of dynamic heterogeneity that are standard tools for considering glassy systems. Specifically, we carry out an analysis in terms of mobility fields and distributions of persistence times and exchange times. In so doing, we show that dynamics in these systems is facilitated by transient disorder in frustrated two-dimensional hydrogen bonding networks. The frustration is the result of unfavorable geometry imposed by strong metal-water bonding. The geometry depends upon the structure of the underlying metal surface. Dynamic heterogeneity of water on the Pt 111 surface is therefore qualitatively different than that for water on the Pt 100 surface. In both cases, statistics of this adlayer dynamic heterogeneity responds asymmetrically to applied voltage.
description: 6 page, 4 figures
Additional file 2 of A systematic review of the health effects of yoga for people with mild cognitive impairment and dementia
Creators: name: Karamacoska, Diana
name: Tan, Tiffany
name: Mathersul, Danielle C.
name: Sabag, Angelo
name: de Manincor, Michael
name: Chang, Dennis
name: Steiner-Lim, Genevieve Z.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Risk of Bias Tool and Item Descriptions Based on Cochrane Criteria.
A galactic-scale origin for stellar clustering
Creators: name: Kruijssen, J. M. Diederik
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We recently presented a model for the cluster formation efficiency (CFE), i.e. the fraction of star formation occurring in bound stellar clusters. It utilizes the idea that the formation of stars and stellar clusters occurs across a continuous spectrum of ISM densities. Bound stellar clusters naturally arise from the high-density end of this density spectrum. Due to short free-fall times, these high-density regions can achieve high star formation efficiencies (SFEs) and can be unaffected by gas expulsion. Lower-density regions remain gas-rich and substructured, and are unbound upon gas expulsion. The model enables the CFE to be calculated using galactic-scale observables. I present a brief summary of the model physics, assumptions and caveats, and show that it agrees well with observations. Fortran and IDL routines for calculating the CFE are publicly available at http://www.mpa-garching.mpg.de/cfe.
description: 4 pages, 1 figure; to appear in The Labyrinth of Star Formation, (eds.) D. Stamatellos, S. Goodwin, and D. Ward-Thompson, Springer, in press
title: Ανάπτυξη μοντέλων εκτίμησης των τροχαίων ατυχημάτων στην Ελλάδα
Creators: name: Νικολαράκης Μιχαήλ
Publisher: name: Technical University of Crete
Year: 2006

description: φ. 1: Εισαγωγή -- Κεφ. 2: Οδικό όχημα -- Κεφ. 3: Τροχαία ατυχήματα -- Κεφ. 4: Παραβάσεις τροχαίας -- Κεφ. 5: Οδική ασφάλεια -- Κεφ. 6: Πολυκριτήρια ανάλυση -- Κεφ. 7: Έρευνα τροχαίων ατυχημάτων και παραβάσεων οδηγών -- Κεφ. 8: Εφαρμογή
Using mineral magnetics and petroleum systems modelling to calibrate hydrocarbon migration: a case study from the UK Central North Sea
Creators: name: Abdulkarim, Maryam Ahmed
Publisher: name: Imperial College London
Year: 2022

description: Through detailed magnetic and petroleum systems analysis, I have identified a relationship between hydrocarbon migration and reservoir magnetic signatures in Paleogene petroleum fields of the UK North Sea. Hydrocarbons in these fields generally diminished the in-reservoir ferromagnetic signature via the destruction of iron (titano)-oxides, and selectively enhanced their paramagnetic content. The enhancement is due to the formation of siderite and minor hexagonal pyrrhotite, pyrite, lepidocrocite and/or vivianite. The precipitation of hexagonal pyrrhotite and lepidocrocite is centred around the oil water transition zone (OWTZ). Lepidocrocite and greigite are also precipitated within the interbedded shales. Siderite is heterogeneously precipitated within some of the hydrocarbon reservoir sandstones and the contacting shales. The precipitation of siderite in these reservoirs is mainly related to hydrocarbon migration direction. Petroleum systems modelling revealed that the reservoirs with anomalously high concentrations of siderite experienced significant vertical migration of hydrocarbons during filling. This is related to the increasing availability of bicarbonate ions and Fe2+ during vertical migration unlike lateral migration. In-reservoir biodegradation of hydrocarbons via methanogenesis also contributed to the precipitation of siderite. Biodegradation and hydrolysis of hydrocarbon is also related to the precipitation of hexagonal pyrrhotite and lepidocrocite respectively. The relationship between these in-reservoir processes and mineral magnetism suggests an application of magnetic proxies to petroleum system analysis. Magnetic susceptibility measurement can be applied to the determination of the OWTZ and hydrocarbon migration direction. Petroleum systems modelling provided an understanding of the migration history of the complex CAD region, West Central Shelf. It revealed that hydrocarbon was sourced via long distance migration from the deeper graben area. The CAD reservoirs were charged at ~ 10 Ma through a fill-spill process. The system was generally seal limited leading to significant hydrocarbon loss via leaks. Present day, the CAD region is spill limited with prospects further west of the system