cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Autonomia finanziaria degli enti territoriali al tempo della crisi, tra unione europea e garanzia dei diritti
Financial autonomy of local authorities at the time of the economical crisis, between European Union and guarantee of rights
Creators: name: Minni, Francesca <1982>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2014
Subjects: IUS/08 Diritto costituzionale

description: La tesi si propone di ricostruire la struttura attuale dell'autonomia finanziaria degli enti locali italiani, e in particolare le regioni italiane, alla luce delle riforme legislative e costituzionali approvate dal Parlamento italiano negli ultimi anni (come ad esempio il bilancio riforma costituzionale equilibrata del 2012). Lo studio si concentra sulla situazione italiana alla luce dei vincoli europei introdotti nel corso degli anni, da quelli contenuti nel Trattato di Maastricht a quelli derivati dalla crisi economica e finanziaria. L'obiettivo è quello di verificare se le scelte del legislatore italiano possano dirsi coerenti con il processo di unione politica europea e quali conseguenze abbiano avuto sulla garanzia dei diritti. In particolare, lo studio si concentra sulla garanzia dei diritti sociali nel contesto politico ed economico attuale, a livello europeo e nazionale, con particolare attenzione al diritto alla salute.
description: The thesis aims to reconstruct the current structure of the financial autonomy of local authorities Italians, and particularly the Italian regions, in the light of legislative and constitutional reforms approved by the Italian Parliament in recent years (such as the balanced budget constitutional reform of 2012) . The study focuses on the Italian situation in the light of European constraints that have taken place over the years from those contained in the Maastricht Treaty to those connected to the current economic and financial crisis. The aim is to verify whether the choices of the Italian legislature are consistent with the process of political European union and what consequences they have had on the guarantee of rights. In particular, the study focuses on the guarantee of social rights in the current political and economic environment, at a European and national level, with particular attention to the right to health.
Enactivism and the â€˜Explanatory Trapâ€™. A Wittgensteinian Perspective
Creators: name: Boncompagni, Anna
Publisher: name: Methode - Analytic Perspectives
Year: 2013

description: This paper explores the enactive approach in cognitive science with an eye on the later Wittgensteinâ€™s philosophy. The aim is not that of answering the question: was Wittgenstein an ante litteram enactivist? He was not, because he was not an ante litteram (cognitive) scientist of any kind. The aim, conversely, is that of answering the question: can enactivism be Wittgensteinian? In answering positively, it will be argued that a Wittgensteinian framework can help enactive cognitive scientists in dissolving certain old problems which they sometimes seem not to be able to get rid of. After the Introduction, the first two sections of the paper concern the Wittgensteinian standpoint on psychological concepts (Section 2) and the enactivist approach in its general terms (Section 3). Section 4 attempts a closer examination of some key concepts â€“ chiefly representations, the inner, the â€œexplanatory gapâ€, the â€œhard problemâ€ of consciousness â€“ considering both the enactivistsâ€™ and Wittgensteinâ€™s attitude towards them. The Conclusion surmises the benefits of a Wittgensteinian perspective also hinting at some other problems which it can help to clarify.
description: Methode - Analytic Perspectives, Vol 2, No 2 (2013): New perspectives for the Philosophy of Cognitive Science
title: Guiding Language Students to Self-Sustained Learning
Creators: name: Checketts, Hyrum Boone
Publisher: name: Utah State University
Year: 2019

description: This portfolio is a compilation of written pieces which express the author’s beliefs about excellence in second language teaching. The views expressed here have been shaped by the author’s personal experience and by his time in the Master of Second Language Teaching (MSLT) program and are supported by relevant research throughout.
This portfolio contains three sections: (1) teaching perspectives, (2) research perspectives, and (3) annotated bibliographies. The teaching perspective section is centered on the author’s teaching philosophy, which emphasizes communication in the target language, classroom community, and student motivation. The second section consists of three research papers written over the course of the MSLT program. The final section includes three annotated bibliographies that review research literature regarding student motivation, nonnative vs native teachers, and the teaching of vocabulary.
Cosmic Ray Acceleration by Supernova Shocks
Creators: name: Berezhko, E. G.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyse the results of recent measurements of nonthermal emission from individual supernova remnants (SNRs) and their correspondence to the nonlinear kinetic theory of cosmic ray (CR) acceleration in SNRs. It is shown that the theory fits these data in a satisfactory way and provides the strong evidences for the efficient CR production in SNRs accompanied by significant magnetic field amplification. Magnetic field amplification leads to considerable increase of CR maximum energy so that the spectrum of CRs accelerated in SNRs is consistent with the requirements for the formation of Galactic CR spectrum up to the energy ~10^17 eV.
description: 30 pages, 8 figures, Solicited talk at 36th COSPAR Scientific Assembly; Beijing, China
Do Coronal Loops Oscillate in Isolation?
Creators: name: Hindman, Bradley W.
name: Jain, Rekha
Publisher: name: arXiv
Year: 2021
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Images of the solar corona by extreme-ultraviolet (EUV) telescopes reveal elegant arches of glowing plasma that trace the corona's magnetic field. Typically, these loops are preferentially illuminated segments of an arcade of vaulted field lines and such loops are often observed to sway in response to nearby solar flares. A flurry of observational and theoretical effort has been devoted to the exploitation of these oscillations with the grand hope that seismic techniques might be used as probes of the strength and structure of the corona's magnetic field. The commonly accepted viewpoint is that each visible loop oscillates as an independent entity and acts as a one-dimensional (1D) wave cavity for magnetohydrodynamic (MHD) kink waves. We argue that for many events, this generally accepted model for the wave cavity is fundamentally flawed. In particular, the 3D magnetic arcade in which the bright loop resides participates in the oscillation. Thus, the true wave cavity is larger than the individual loop and inherently multidimensional. We derive the skin depth of the near-field response for an oscillating loop and demonstrate that most loops are too close to other magnetic structures to oscillate in isolation. Further, we present a simple model of a loop embedded within an arcade and explore how the eigenmodes of the arcade and the eigenmodes of the loop become coupled. In particular, we discuss how distinguishing between these two types of modes can be difficult when the motions within the arcade are often invisible.
description: 14 pages, 7 figures, an mp4 movie has been included as an ancillary file as a supplement to figure 1, Accepted for publication in the Astrophysical Journal
Skyrmion bound state and dynamics in an antiferromagnetic bilayer racetrack
Creators: name: Silva, R. C.
name: Silva, R. L.
name: Carvalho-Santos, V. L.
name: Moura-Melo, W. A.
name: Pereira, A. R.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the dynamics of two skyrmions lying in distinct layers of an antiferromagnetic bilayer system, consisting of nanostripes with the shape of racetracks. The top and bottom nanostripes are separated by a height offset and they are coupled through a ferromagnetic exchange, allowing the interaction between the skyrmions from both layers. Depending on the distance between the skyrmions they attract each other sufficiently to achieve a bound state. We also analyze their dynamics when an electric current is applied in a unique layer and we determine how the bound-state nucleation depends on the current density and vertical distance between the skyrmions. Finally, we analyzed the robustness of the bound states by considering two situations: 1) a system constituted by clean or homogeneous antiferromagnetic racetracks; 2) a system in which randomly distributed magnetic impurities in both layers are included in the system.
description: 8 pages, 7 figures
Realismo in ontologia, idealismo in arte. Una tensione mortale
Creators: name: Andina, Tiziana
Publisher: name: Methode - Analytic Perspectives
Year: 2012

description: The aim of this paper is to discuss the theoretical structure of the philosophy of art sketched by Arthur Danto and it suggests a possible reconsideration of his theory involving the role of the aesthetics in the philosophy of art. The aesthetics â€“ this is the main thesis of the paper â€“ may usefully integrate the researches in the philosophy of art, also in the Dantian's theory, trough the study of the structure of the human perception, which is a fundamental part of the human cognition, as well as of the main features of the aesthetics proprieties of the works of art.
description: Methode - Analytic Perspectives, Vol 1, No 1 (2012): Art, Objects
title: Licentious Legends: A Folklore Podcast
Creators: name: Haynes, Alexandra L.
Publisher: name: Utah State University
Year: 2019

description: Licentious Legends was created out of a need to both understand and educate about sexual contemporary legends; not just what they are and what defines them, but the effect that they have on those who experience them. The purpose of this podcast is not to shame, but to take what has been found and educate about the joys and dangers of these legends. These legends range from the everyday (such as "The Hook"), to legends about a young man killing himself with a plunger. In an effort to gather as many examples as they could, Faye interviewed several of their friends from across the country. Each of their guests experienced sexual contemporary legends inherent not only to their location, but their identities. For example, they interviewed two transgender pansexual men, one gay cis man, and a bisexual cis woman. This allowed common ground between not only the people interviewed, but the legends they experienced growing up. They also researched examples of the older legends, to find where they may have originated from, and how they have evolved over the past few decades. These sexual legends have not only shamed countless young people, but have also stunted their emotional and mental growth, at least in the realm of relationships and sex. Told through the medium of podcasting, Licentious Legends opens itself to listeners of (almost) all ages, and allows for those who would not have the time to read a typical thesis to still hear and digest the information presented.
title: Fragmentary Memories: The Cultural Significance of Famine Echoes in Dracula
Creators: name: Hegarty, Moira
Publisher: name: Utah State University
Year: 2019

description: This Plan B thesis explores the questions: What echoes of the 1845 Potato famine exist in Dracula and how do those echoes impact our understanding of the famine’s cultural impact? Dracula has been studied extensively both as an important example of gothic Victorian literature and as a chance to reclaim a native Irish author from the British. By looking at Dracula through the lens of Ireland’s 1845 Potato famine some of the structural and narrative oddities resolve themselves, such as Stoker’s decision to introduce so many opposing images and ideas to create a sense of uncertainty and rob the reader of an overarching allegory to guide the narrative. Rather than focusing on how a famine lens resolves issues with the narrative, this thesis will focus on three scenes from the novel that display distinct echoes of the famine and what they can teach us about the lasting impact of the violent imagery that surfaced during the tragedy. Each scene is discussed individually with the famine-based image that it reflects and the role of those images in the novel and culturally. Mina and Lucy’s conversation about graves with Mr. Swales echoes the questions surrounding the cultural and psychological impact of being surrounded by the dead and dying during the famine. The discovery of Lucy’s vampirism evokes images of mothers cradling their children during the crisis, but also casts a sinister shadow on the devoutness of those mothers. The arrival of the Demeter in Whitby, the final scene this thesis concerns itself with, has interesting connections to the cultural image of the coffin ships, and the importance of the ship’s log in unraveling the mystery of what happened echoes the weight placed on the diaries of Irish emigrants who traveled on the coffin ships. Examining these three scenes through the historic and cultural sense of the famine allows us to begin understanding not only the famine’s influence on Dracula but also why famine scholars are interested in classifying the novel as part of the famine literature canon. As a whole, this thesis aims to demonstrate the value in further pursuing the role of novels, such as Dracula, that are drawing on famine themes but not necessarily about the famine, in understanding the psychological traumas embedded in the cultural memory as a result of the 1845 famine.
title: An ANN-Based System for Lateral Misalignment and Vertical Clearance Estimation of an Electric Vehicle During Dynamic Wireless Charging
Creators: name: Saha, Sanat Kumar
Publisher: name: Utah State University
Year: 2019

description: Due to decaying fossil fuel reserves, oil price fluctuation and detrimental effects on climate the use of fossil fuel has, people are getting more interested in other alternative energy sources. In the past couple of decades, the Electric Vehicles have emerged as a robust environment-friendly alternative to conventional gasoline-driven vehicles. Although EVs have a problem with the limited energy storage, Stationary and Dynamic Wireless Power Transfer (WPT) systems for the charging of EVs can be an effective solution. However, in a WPT system, energy efficiency and energy transfer capability are significantly affected by the level of Lateral Misalignment. The real-time estimation of LTM, followed by some corrective actions, could result in better energy efficiency and the power transfer capability of the system. This report describes the theory, design, and simulation of an Artificial Neural Network based system for predicting LTM and Vertical Clearance of EVs, so that the LTM can be corrected to optimize Wireless Power Transfer for EVs.
Katalog af Totaloplysninger
Creators: Lægemiddelstyrelsen
Sundhedsstyrelsen
Lægemiddelstyrelsen
Publisher: name: Rigsarkivet
Year: 2022

description: Formål med KAT er at samle informationen, registerdata, til efterlevelse af lægemiddelloven, specielt i forhold til administration af markedsføringstilladelser for lægemidler i Danmark, tilladelser og inspektion af danske lægemiddelvirksomheder, medicovirksomheder (fabrikanter af medicinsk udstyr), lægemiddelkontrol, administration af medicinpriser til apoteker, leveringsevne, m.m.
Data i KAT finder også anvendelse i blandt andet lægepraksissystemer, FMK, elektroniske patientjournaler (sygehuse), elektroniske omsorgsjournaler (kommuners hjemmepleje), samt i forbindelse med forskning i lægemidler.
Forming the Moon from terrestrial silicate-rich material
Creators: name: de Meijer, R. J.
name: Anisichkin, V. F.
name: van Westrenen, W.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Recent high-precision measurements of the isotopic composition of lunar rocks demonstrate that the bulk silicate Earth and the Moon show an unexpectedly high degree of similarity. This is inconsistent with one of the primary results of classic dynamical simulations of the widely accepted giant impact model for the formation of the Moon, namely that most of the mass of the Moon originates from the impactor, not Earth. Resolution of this discrepancy without changing the main premises of the giant impact model requires total isotopic homogenisation of Earth and impactor material after the impact for a wide range of elements including O, Si, K, Ti, Nd and W. Even if this process could explain the O isotope similarity, it is unlikely to work for the much heavier, refractory elements. Given the increasing uncertainty surrounding the giant impact model in light of these geochemical data, alternative hypotheses for lunar formation should be explored. In this paper, we revisit the hypothesis that the Moon was formed directly from terrestrial mantle material. We show that the dynamics of this scenario requires a large amount of energy, almost instantaneously generated additional energy. The only known source for this additional energy is nuclear fission. We show that it is feasible to form the Moon through the ejection of terrestrial silicate material triggered by a nuclear explosion at Earths core-mantle boundary (CMB), causing a shock wave propagating through the Earth. Hydrodynamic modelling of this scenario shows that a shock wave created by rapidly expanding plasma resulting from the explosion disrupts and expels overlying mantle and crust material.
description: 26 pages, 5 figures, 1 table
Bovine Babesiosis: A potential threat to cattle health
Creators: name: Jyoti Kumari1, Sonam Bhatt2, Sudhanshu Kumar1, Anil Kumar3, Ajit Kumar4
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: Introduction

Babesia genus was named after pathologist Victor Babes who discovered this organism first in red blood cells of cattle in 1888 in Romania, later Smith and Kilborne in 1893 demonstrate that the organism was transmitted by Boophilus annulatus to cattle.

Bovine babesiosis is a tick-transmitted disease affecting cattle and buffalo, caused by species of the genus Babesia, an obligate intracellular protozoan that invades and destroys red blood cells, leading to considerable mortality and morbidity in cattle. The disease is globally distributed and can occasionally infect humans. Its acute form is marked by fever, intravascular hemolysis resulting in progressive anemia, jaundice, hemoglobinuria, and splenomegaly, while the chronic form leads to anemia and variable weight loss. As one of the most widespread parasites globally, babesiosis is the second most common blood borne parasitic disease after trypanosomiasis. The economic impact on the cattle industry is substantial, with losses from mortality, reduced milk and meat production, and the costs associated with tick control. Synonyms for the disease include Texas fever, Redwater disease, Piroplasmosis, and Tick fever.
ESDH-system DocuLive
Creators: Handicapvirksomheden
Region Hovedstadens Psykiatri
Publisher: name: Rigsarkivet
Year: 2022

description: Det forretningsmæssige formål er en fælles ESDH løsning for stabe og virksomheder i Region Hovedstaden. De operationelle formål omfatter en journalisering der kan:
- Dokumentere og skabe overblik over sagsbehandlingen og øvrige aktiviteter, der er nødvendigt for at følge lovgivningen og god forvaltningsskik. - Sikre at sager og dokumenter er nemt kan genfindes.
- Gøre viden og erfaringer tilgængelige i den forstand, at den enkelte medarbejder skal have mulighed for at finde relevante sager og dokumenter inden for et bestemt område eller om et givet emne på tværs af koncernen.
- Støtte sagsbehandling og sagsstyring og øget kvalitet og effektivitet i sagsbehandlingen.
- Trækkes statistik om præcist afgrænsede sagsområder, afgørelser, sagsbehandlingstider m.m. på udvalgte sagsområder samt anden ledelsesinformation.
Endelig lægger journaliseringen også op til et mere langsigtet formål om at synliggøre en historik i koncernens sager og hermed skabe mere langsigtet information.
KNOCKOUT OF API5 WITH CRISPR/CAS9 CONTRIBUTES TO GEMICITABINE RESISTANCE IN PANCREATIC CANCER
Creators: name: Liu, Dongxue
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2023

description: Background and objectives: Pancreatic cancer is one of the most fatal cancers, and the incidence is still rising. Cigarette smoking, diabetes mellitus, alcohol, chronic pancreatitis, and specific gene mutations are thought to be risk factors for pancreatic cancer. Because lack of specific symptoms, most pancreatic cancer cannot be diagnosed in the early stage. Treatments for pancreatic cancer include surgery, chemotherapy, radiotherapy, and interventional therapy. Few patients have the opportunity to accept surgery due to the advanced diagnosis. Chemotherapy plays a crucial role in pancreatic cancer and can be used as neoadjuvant chemotherapy and late-stage cancer therapy. For decades, gemcitabine was considered to be the base of chemotherapy for pancreatic cancer. The objective was to explore the relationship between API5 and gemcitabine resistance in pancreatic cancer by using the CRISPR/Cas9 technology. Methods: API5 is knocked out by using CRISPR/Cas9 in TB32047 and PANC1 cell lines. RT-PCR, Western Blot, and sequencing confirm the knockout cells. Then we perform gemcitabine resistance analysis after 72h drug treatment. BD LSRFortessa™ Flow Cytometer is used to carry out the apoptosis assay. We use Western Blot and RT-PCR to find the possible pathway. Results: We confirm that API5 knockout cells are resistant to gemcitabine treatment compared to wild-type and negative control cells. The IC50 of gemcitabine is higher in API5-KO cells than in wild-type and negative control cells in both TB32047 and PANC1 cell lines. Erk/Bim pathway might participate in the resistance to gemcitabine treatment. Conclusion: Our research discovers that CRISPR/Cas9 deletion of API5 shows a chemoresistance to gemcitabine in TB32047 and PANC1 cell lines. API5 might be a new target of gemcitabine therapy. API5 is also involved in regulating the expression level of erk, Bim pathway.
Bosted System
Creators: Blåkærgård
Boligerne Jossiasens Vej
Boligerne Lene Breddahls gade
Boligerne Svalevej
Bygmarken
Bækketoften
Bo- og Aktivitetscenter Elbækvej
Gårdhaven
Granbakken
Den sikrede døgninstitution Grenen
Gudenåkollegiet
Hald Ege
Handi-Ka
Himmelbjerggården
Kollegiet Hinnerup
Holmstrupgård
MultifunC Midtjylland
Mosetoft
Nørholm Kollegiet
Pilebakken
Specialområde Børn og Unge
Bostedet Sct. Mikkel
Sønderparken
Bo- Rehabiliterings- og Aktivitetstilbuddet Tagdækkervej
Botilbud Tangkær
Publisher: name: Rigsarkivet
Year: 2022

description: Bosted System har det formål, at Region Midtjylland opfylder journalbekendtgørelsen for de borgere, der er indskrevet i regionens sociale tilbud. Benyttes også i kommunikationen med kommunerne, som bevilliger borgerne  ophold til regionens tilbud. Hver borger har en §141 handleplan efter serviceloven, som kommunal sagsbehandler og borger er ansvarlig for. Samt en pædagogisk handleplan, som udarbejdes mellem medarbejder i socialt tilbud og borger med tilhørende delmål.
Approximate solutions of some predator-prey ecological models
Creators: name: Brearley, John R.
Publisher: name: University of British Columbia
Year: 2010

description: The purpose of this thesis is to develop and evaluate approximate analytical solutions of nonlinear differential equations that purport to model physical ecological systems of a predator-prey nature. A variety of analytical techniques, some well known and some new are used to obtain analytical solutions for these models. Solutions are obtained for five different predator-prey systems, and simulations show that these solutions are accurate over wide ranges of initial conditions and system parameters. These literal parameter solutions allow the user to readily determine which components of the solutions are sensitive to which parameters, and thus avoid the traditional heuristic computer sensitivity studies.
TopoDetect: Framework for Topological Features Detection in Graph Embeddings
Creators: name: Haddad, Maroun
name: Bouguessa, Mohamed
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: TopoDetect is a Python package that allows the user to investigate if important topological features, such as the Degree of the nodes, their Triangle Count, or their Local Clustering Score, are preserved in the embeddings of graph representation models. Additionally, the framework enables the visualization of the embeddings according to the distribution of the topological features among the nodes. Moreover, TopoDetect enables us to study the effect of the preservation of these features by evaluating the performance of the embeddings on downstream learning tasks such as clustering and classification.
Die IL-4-abhängige Inhibition der Expression des Mustererkennungsrezeptors Mincle
Creators: name: Hupfer, Thomas
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2023
Subjects: Mincle
MCL
Dectin2
Antigen presenting cells
M. tuberculosis
Mycobacteria
infection immunology
IL-4
interleukin 4
TDB
TDM
cord factor
tuberculosis
M1
M2

description: Hintergrund und Ziele Die C-Typ-Lektin-Rezeptoren des Dectin-2-Clusters Mincle, MCL und Dectin-2 erkennen immunologisch Bestandteile der Zellwand von Mycobacterium tuberculosis, beispielsweise den mykobakteriellen Cordfaktor durch MCL und Mincle. Nach Erkennung des Liganden Cordfactor werden antibakterielle Effektorfunktionen des angeborenen Immunsystems aktiviert und die Expression der Rezeptoren erhöht. Es wurde beobachtet, dass das Zytokin Interleukin-4, welches mit einer alternativen Makrophagenaktivierung assoziiert ist, die Expression dieser Rezeptoren inhibiert. In der vorliegenden Arbeit soll dieser Effekt charakterisiert werden. Methoden Es erfolgte die Analyse humaner und muriner antigenpräsentierender Zellen (Monozyten, Makrophagen, dendritische Zellen) in Zellkultur. Untersuchungen erfolgten nach Stimulation mit Liganden für C-Typ-Lektin-Rezeptoren (Trehalosedibehenat, Trehalosedimykolat), Toll-Like-Rezeptor 4 (Lipopolysaccharid) und weiterer Zytokine (M-CSF, GM-CSF) in An- oder Abwesenheit von Interleukin-4. Der Einfluss auf die Expression verschiedener C-Typ-Lektine wurde mittels RT-PCR und Durchflusszytometrie untersucht. Die Analyse der funktionellen Zytokinantwort erfolgte mittels ELISA. Ergebnisse und Beobachtungen Interleukin-4 induzierte eine konzentrationsabhängige, anhaltende Inhibition der Expression von Mincle und anderen C-Typ-Lektinen des Dectin-2-Clusters sowohl auf humanen als auch murinen Zellen, wobei der Effekt sowohl auf Makrophagen als auch auf dendritischen Zellen nachzuweisen war. Unter Interleukin-4 zeigte sich eine Inhibition der induzierten mRNA-Expression von Mincle nach Stimulation mit dessen Liganden, nicht jedoch nach Stimulation mit dem Toll-Like-Rezeptor-Agonisten Lipopolysaccharid. Die Inhibition der mRNA-Expression übersetzte sich in eine reduzierte Proteinexpression und eine reduzierte funktionelle Antwort auf Mincle-abhängige Stimuli im Sinne einer reduzierten Produktion proinflammatorischer Zytokine. Der Effekt war abhängig von dem im Interleukin-4 Signalweg wichtigen Transkriptionsfaktor STAT6.   Schlussfolgerungen Interleukin-4 inhibiert die Expression der für die Erkennung von Mycobacterium tuberculosis wichtigen Mustererkennungsrezeptoren des Dectin-2-Clusters auf antigenpräsentierenden Zellen des angeborenen Immunsystems. Dieser Mechanismus könnte zu einer erhöhten Suszeptibilität und erhöhtem Reaktivierungsrisiko einer latenten Tuberkulose in einem von Th2-Zytokinen wie Interleukin-4 geprägten Milieu beitragen.
Landsdækkende register over stofmisbrugere, der modtager eller har modtaget behandling
Creators: Sundhedsstyrelsen
Publisher: name: Rigsarkivet
Year: 2022

description: Behandlingens formål og evt. delformål:* a) danne grundlag for Sundhedsstyrelsens løbende statistik til belysning af stofmisbrugets art og omfang i den danske befolkning - blandt andet til brug for EU’s narkotikaagentur EMCDDA b) forsyne de myndigheder, der er ansvarlige for behandlingen af stofmisbrugere på såvel overordnet som regionalt niveau med det nødvendige beslutningsgrundlag c) bidrage til forskning d) danne grundlag for den økonomiske udligning mellem amter og kommuner.
A note on Verhulst's logistic equation and related logistic maps
Creators: name: Gutierrez, M. Ranferi
name: Reyes, M. A.
name: Rosu, H. C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider the Verhulst logistic equation and a couple of forms of the corresponding logistic maps. For the case of the logistic equation we show that using the general Riccati solution only changes the initial conditions of the equation. Next, we consider two forms of corresponding logistic maps reporting the following results. For the map x_{n+1} = rx_n(1 - x_n) we propose a new way to write the solution for r = -2 which allows better precision of the iterative terms, while for the map x_{n+1}-x_n = rx_n(1 - x_{n+1}) we show that it behaves identically to the logistic equation from the standpoint of the general Riccati solution, which is also provided herein for any value of the parameter r.
description: 6 pages, 3 figures, 7 references with titles
The un-sustainable housing market in Poland. Statistical data analysis and the energy embodied in economic value as a new sustainability indicator
Creators: name: Cebrat, Krzysztof
Publisher: name: Faculty of Architecture, Wrocław University of Technology, Wrocław
Year: 2014
Subjects: sustainable architecture, energy embodied in economic value, indicators of sustainability

description: ARCHITECTUS; ISSN 1429-7507
Landsdækkende register over stofmisbrugere, der modtager eller har modtaget behandling
Creators: Sundhedsstyrelsen
Publisher: name: Rigsarkivet
Year: 2022

description: Behandlingens formål og evt. delformål:* a) danne grundlag for Sundhedsstyrelsens løbende statistik til belysning af stofmisbrugets art og omfang i den danske befolkning - blandt andet til brug for EU’s narkotikaagentur EMCDDA b) forsyne de myndigheder, der er ansvarlige for behandlingen af stofmisbrugere på såvel overordnet som regionalt niveau med det nødvendige beslutningsgrundlag c) bidrage til forskning d) danne grundlag for den økonomiske udligning mellem amter og kommuner
title: Racial Conflict in Early Utah: Mormon, Native American and Federal Relations
Creators: name: Embleton, Raelyn M.
Publisher: name: Utah State University
Year: 2019

description: This website is for teachers to gain information and sources about Utah history during the early territorial period, specifically relating to conflicts between Mormon settlers, Native Americans, and federal officials. The content and site were designed with the C3 curriculum in mind, as such, at the bottom of this page you can find a downloadable Inquiry Design Model Blueprint. As you teach students this information, the compelling question to have students focus on is: “Does culture and the interaction of cultures shape the development of place?” Each event highlighted on this website is related to the other and demonstrates how the different cultures of Mormons, Native Americans, and non-Mormon federal officials interacted and shaped the development of Utah. From left to right, the tabs on the top of the page move through major episodes in this history chronologically. Hover on each tab to reveal more tabs with additional information on each conflict. Each conflict also has a tab for additional lesson ideas and resources specific to that event. The Inquiry Design Model Blueprint’s supporting questions and tasks are meant to build upon one another, so when students reach the end of the unit they should have an almost completed essay that demonstrates how and if cultures and their interaction shaped the development of the Utah territory. The extension activity takes the development of place further by examining how the memory of the Bear River Massacre has changed as the area has changed. To wrap up the unit by taking informed action, if possible, have students visit different memorials and monuments around Utah dedicated to this time period. At each site, students should analyze and evaluate if the monuments truly tell the multicultural history of Utah.
Horizon Thermodynamics and Gravitational Field Equations in Horava-Lifshitz Gravity
Creators: name: Cai, Rong-Gen
name: Ohta, Nobuyoshi
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We explore the relationship between the first law of thermodynamics and gravitational field equation at a static, spherically symmetric black hole horizon in Hořava-Lifshtiz theory with/without detailed balance. It turns out that as in the cases of Einstein gravity and Lovelock gravity, the gravitational field equation can be cast to a form of the first law of thermodynamics at the black hole horizon. This way we obtain the expressions for entropy and mass in terms of black hole horizon, consistent with those from other approaches. We also define a generalized Misner-Sharp energy for static, spherically symmetric spacetimes in Hořava-Lifshtiz theory. The generalized Misner-Sharp energy is conserved in the case without matter field, and its variation gives the first law of black hole thermodynamics at black hole horizon.
description: Latex, 15 pages; v2: typos fixed,v3, minor changs and published vserion
Normofraktionierte Bestrahlung, nicht aber Temozolomid, moduliert den immunogenen und onkogenen Phänotyp menschlicher Glioblastom-Zelllinien
Creators: name: Schatz, Julia
Publisher: name: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Year: 2023

description: Im Rahmen unserer Arbeit wurden menschliche Glioblastomzellen unter anderem auf die Expression sowohl immunsuppressiver als auch immunstimulierender Checkpoint Moleküle sowie des onkogenen Faktors EGFR nach Behandlung mit Radio- und/oder Chemotherapie untersucht. Zusammenfassend zeigte sich, dass Temozolomid keinen signifikanten Einfluss auf die Oberflächenexpression von Checkpoint-Molekülen oder des EGF-Rezeptors hat. Der Einfluss normofraktionierter Radiotherapie auf die Expression von Immun-Checkpoint- Molekülen auf der Oberfläche von GBM-Zellen nach hingegen deutlich nachweisbar, jedoch äußerst heterogen. Insbesondere die Expression von PD-L1, PD-L2, HVEM und EGFR wurde durch die durchgeführte Strahlentherapie an den untersuchten GBM-Zellen signifikant herauf reguliert. Ein signifikanter Unterschied zwischen RT- und RCT Behandlung konnte nicht festgestellt werden.
title: The Effects of Behavior Skills Training and Self-Monitoring on Paraprofessionals’ Use of Incidental Teaching Procedures in a Preschool Classroom
Creators: name: Thompson, Bayley
Publisher: name: Utah State University
Year: 2019

description: This project investigated effects of behavior skills training (BST) and self-monitoring on paraprofessionals’ use of incidental teaching procedures in a preschool classroom. Target behaviors involved correctly implementing two incidental teaching procedures: inadequate portions and sabotage. During baseline the paraprofessional displayed low levels of correct implementation of incidental teaching procedures. The participant then completed a training which included BST and self-monitoring. In addition to treatment data collection, the paraprofessional completed an incidental teaching questionnaire and a social validity survey as secondary measures. Results showed that the BST and self-monitoring package improved the participants’ implementation of correct incidental teaching procedures.
Speech synthesis by concatenation of Digital waveform fragments
Creators: name: Chu, Thien-Ke
Publisher: name: University of British Columbia
Year: 2010

description: A method to rule-synthesize speech by concatenation of digital waveform fragments at a subphonemic level is presented. No special hardware is needed to implement this software synthesizer other than a D/A converter and an ordinary audio system. Computer software for an on-line analysis-by-synthesis process was developed. Phonetic cues, such as characteristic waveform fragments, durations of each quasi-steady state and the transition motion of a certain number of phonemes were extracted and stored. Classifications of phonetic cues were possible and necessary to reduce the storage requirement and to obtain rules for synthesis. An interpolation scheme was developed to generate transient waveforms to eliminate the discontinuities at the concatenated junctions. Pitch variation was found to be the most influential factor for creating intonation in polysyllable utterances and was achieved by a pitch modification routine included in the synthesis program. Test procedures and results are reported in which a comparable vowel recognition rate for synthetic words is 93% vs. the 94% of digitized natural words in the first test. Further studies are needed to generalize the method to synthesize unrestricted text. The findings of the phonetic cues could be applied to speech recognition in future work.
Semaglutide and blood pressure: an individual patient data meta-analysis
Creators: name: Kennedy, Cormac
name: Hayes, Peter
name: F.G. Cicero, Arrigo
name: Dobner, Stephan
name: Le Roux, Carel W.
name: W. McEvoy, John
name: Zgaga, Lina
name: Hennessy, Martina
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background and Aims Randomized clinical trials (RCTs) assessing semaglutide reported reductions of systolic blood pressure (SBP) in trial populations with baseline blood pressure in the normotensive range. This study aimed to determine whether this SBP reduction is greater in hypertensive groups.
Methods Individual patient data (IPD) from three RCTs examining the effect of semaglutide 2.4 mg on body weight over 68 weeks were included. Trial participants were categorized according to a hypertension diagnosis, treatment or baseline measurement (HTN), baseline SBP > 130 mmHg (HTN130) or >140 mmHg (HTN140), and those with apparent resistant hypertension (RH). The primary analysis compared the in-trial change in SBP in the semaglutide and placebo arms. Alterations of anti-hypertensive medications were quantified by treatment intensity score and compared between arms. These analyses were performed using analysis of covariance.
Results Overall, 3136 participants were included. The difference in SBP change between the treatment (n = 2109) and placebo (n = 1027) groups was −4.95 mmHg [95% confidence interval (CI) −5.86 to −4.05] overall. This difference was −4.78 mmHg (95% CI −5.97 to −3.59) for HTN, −4.93 mmHg (95% CI −6.75 to −3.11) for HTN130, −4.09 mmHg (95% CI −7.12 to −1.06) for HTN140, and −3.16 mmHg (95% CI −8.69–2.37) for RH. Reduction in SBP was mediated substantially by weight loss. The anti-hypertensive treatment intensity score decreased for those on semaglutide compared to placebo (−0.51; 95% CI −0.71 to −0.32).
Conclusions This IPD analysis of three large RCTs found blood pressure reductions with semaglutide in participants with hypertension that were similar to those seen in all trial participants. This finding may in part be due to concurrent reductions to antihypertensive medications. These results suggest that semaglutide is a useful adjunctive treatment for patients with hypertension and obesity.
Råstofindvinding på land i Danmark 2016
Creators: Danmarks Statistik
Publisher: name: Rigsarkivet
Year: 2022

description: Formålet med statistikken er at producere statistik over den fysiske råstofindvinding i Danmark. Anvendelsesområder: Offentlige og private planlægningsformål, uddannelse og offentlig debat. Brugere: Kommuner, regioner, ministerier, organisationer, internationale organisationer, pressen, private virksomheder samt privatpersoner.
title: A Focus Group Analysis of Interdisciplinary Knowledge Held by Special Education Teachers and Community Rehabilitation Service Providers
Creators: name: Pacheco, Tabitha
Publisher: name: Utah State University
Year: 2019

description: This research study describes the current understanding of high school special education teachers and community rehabilitation providers (CRP) staff regarding the direct transition services available through each party, the challenges and barriers encountered by each party, and recommendations for improving collaboration between special education teachers and CRP staff to improve student outcomes. Current research emphasizes the importance of interagency collaboration and that collaboration can improve student post-secondary outcomes. The method included three focus groups. Thematic analysis revealed key themes in the areas of experiences, questions, barriers, collaboration, and recommendations. The results and recommendations from this study may provide guidance for special education teacher and CRP staff training. Future research should expand upon these themes across more participants and include Vocational Rehabilitation (VR) Counselors.
title: Towards Conjunctive Management of Surface Water and groundwater in the Mediterranean
Creators: name: Lagod, Matthew
Publisher: name: Utah State University
Year: 2019

description: One of the fundamental principles of integrated water resources management is the interconnected nature of water in the hydrological cycle, including the interactions between surface water and groundwater. Although scientists have long recognized these interactions, in many cases they are not reflected in natural resources policies and management practices. As a result, the allocation of water resources by public authorities may not be optimal, and may furthermore lead to long-term degradation of water resources and the ecosystems they sustain. In response to this and to growing pressure on water resources from increasing human populations, water experts have developed a body of knowledge termed “conjunctive water resources management” to promote management approaches that treat surface water, groundwater and other components of the water cycle as a single, interconnected resource. The aim of conjunctive management is to ultimately increase the supplies of fresh water that are available for human use, to maximize their economic and social benefits while minimizing risks to the environment and ecosystems.
This paper will examine the potential for application of conjunctive management approaches in the Mediterranean region, where more than half of the countries fall below the threshold for water scarcity. Following an overview of integrated water resources management and conjunctive management techniques, a series of case studies will document the state of water resources management in three Mediterranean countries (Lebanon, Montenegro and Morocco), and provide recommendations that could assist the countries in moving towards implementation (or expansion) of conjunctive management practices.
The positive semidefinite Grothendieck problem with rank constraint
Creators: name: Briet, Jop
name: Filho, Fernando Mario de Oliveira
name: Vallentin, Frank
Publisher: name: arXiv
Year: 2009
Subjects: subject: Optimization and Control (math.OC)
subject: Data Structures and Algorithms (cs.DS)
subject: Combinatorics (math.CO)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 68W25, 90C22

description: Given a positive integer n and a positive semidefinite matrix A = (A_{ij}) of size m x m, the positive semidefinite Grothendieck problem with rank-n-constraint (SDP_n) is maximize \sum_{i=1}^m \sum_{j=1}^m A_{ij} x_i \cdot x_j, where x_1, ..., x_m \in S^{n-1}. In this paper we design a polynomial time approximation algorithm for SDP_n achieving an approximation ratio of γ(n) = \frac{2}{n}(\frac{Γ((n+1)/2)}{Γ(n/2)})^2 = 1 - Θ(1/n). We show that under the assumption of the unique games conjecture the achieved approximation ratio is optimal: There is no polynomial time algorithm which approximates SDP_n with a ratio greater than γ(n). We improve the approximation ratio of the best known polynomial time algorithm for SDP_1 from 2/πto 2/(πγ(m)) = 2/π+ Θ(1/m), and we show a tighter approximation ratio for SDP_n when A is the Laplacian matrix of a graph with nonnegative edge weights.
description: (v3) to appear in Proceedings of the 37th International Colloquium on Automata, Languages and Programming, 12 pages
Supplemental Figures and Tables from Sex-specific speed-accuracy trade-offs shape neural processing of acoustic signals in a grasshopper
Creators: name: Clemens, Jan
name: Ronacher, Bernhard
name: Reichert, Michael S.
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Speed-accuracy trade-offs—being fast at the risk of being wrong—are fundamental to many decisions and natural selection is expected to resolve these trade-offs according to the costs and benefits of behaviour. We here test the prediction that females and males should integrate information from courtship signals differently because they experience different payoffs along the speed-accuracy continuum. We fitted a neural model of decision making (a drift–diffusion model of integration to threshold) to behavioural data from the grasshopper Chorthippus biguttulus to determine the parameters of temporal integration of acoustic directional information used by male grasshoppers to locate receptive females. The model revealed that males had a low threshold for initiating a turning response, yet a large integration time constant enabled them to continue to gather information when cues were weak. This contrasts with parameters estimated for females of the same species when evaluating potential mates, in which response thresholds were much higher and behaviour was strongly influenced by unattractive stimuli. Our results reveal differences in neural integration consistent with the sex-specific costs of mate search: males often face competition and need to be fast, while females often pay high error costs and need to be deliberate.