cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease
Creators: name: Demain, Jeffrey G.
name: Bernstein, Jonathan A.
name: Phipatanakul, Wanda
name: Cohn, John R.
name: Nel, Andre
name: Barnes, Charles S.
name: Levetin, Estelle
name: Alexis, Neil E.
name: Horner, Elliott
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Climate change is a constant and ongoing process. It is postulated that human activities have reached a point at which we are producing global climate change. This article provides suggestions to help the allergist/environmental physician integrate recommendations about improvements in outdoor and indoor air quality and the likely response to predicted alterations in the earth’s environment into their patient’s treatment plan. Many changes that affect respiratory disease are anticipated. Examples of responses to climate change include energy reduction retrofits in homes that could potentially affect exposure to allergens and irritants, more hot sunny days that increase ozone-related difficulties, and rises in sea level or altered rainfall patterns that increase exposure to damp indoor environments. Climate changes can also affect ecosystems, manifested as the appearance of stinging and biting arthropods in new areas. Higher ambient carbon dioxide concentrations, warmer temperatures, and changes in floristic zones could potentially increase exposure to ragweed and other outdoor allergens, whereas green practices such as composting can increase allergen and irritant exposure. Finally, increased energy costs may result in urban crowding and human source pollution, leading to changes in patterns of infectious respiratory illnesses. Improved governmental controls on airborne pollutants could lead to cleaner air and reduced respiratory diseases but will meet strong opposition because of their effect on business productivity. The allergy community must therefore adapt, as physician and research scientists always have, by anticipating the needs of patients and by adopting practices and research methods to meet changing environmental conditions.
Gate-tunable phonon magnetic moment in bilayer graphene
Creators: name: Zhang, Xiao-Wei
name: Ren, Yafei
name: Wang, Chong
name: Cao, Ting
name: Xiao, Di
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We develop a first-principles quantum scheme to calculate the phonon magnetic moment in solids. As a showcase example, we apply our method to study gated bilayer graphene, a material with strong covalent bonds. According to the classical theory based on the Born effective charge, the phonon magnetic moment in this system should vanish, yet our quantum mechanical calculations find significant phonon magnetic moments. Furthermore, the magnetic moment is highly tunable by changing the gate voltage. Our results firmly establish the necessity of the quantum mechanical treatment, and identify small-gap covalent materials as a promising platform for studying tunable phonon magnetic moment.
description: 6 pages, 3 figures
Allergist-Reported Trends in the Practice of Food Allergen Oral Immunotherapy
Creators: name: Vickery, Brian P.
name: Greenhawt, Matthew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Food allergen oral immunotherapy (OIT) is an experimental, immune-modifying therapy that may induce clinical desensitization in some patients. OIT is still in early phase clinical research, but some provider may offer OIT as a clinical service. To understand the current practices of allergists performing OIT an on-line survey was emailed to members of the American Academy of Allergy Asthma and Immunology. Among 442 respondents, 61 (13.8%) reported participating in OIT, including 28 in non-academic settings. Informed consent for OIT was obtained by 91.3%, IRB approval by 47.7% and Investigational New Drug (IND) approval by 38.1%. Compared to non-academic participants, more academic participants used peanut OIT, obtained IRB and IND (p <0.0001 respectively), and challenged patients prior to entry (p=0.008). More non-academic providers billed the patient or insurance for reimbursement (p<0.0001). Low reported regard for the importance for FDA approval or a standardized product (increased odds), and high regard for better safety data (decreased odds) were associated with considering to offer OIT as a service. Significant differences exist in OIT occurring in academic vs. non-academic settings. Further assessment is needed regarding the different motivations and practice styles among providers offering OIT, and those considering doing so.
Discovery of the first hermit crab (Crustacea: Decapoda: Parapaguridae) associated with hydrothermal vents
Creators: name: LEMAITRE, Rafael
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: A new species of hermit crab of the family Parapaguridae, Paragiopagurus ventilatus, is described from
 hydrothermal vent habitats in the Tashi fishing grounds, northeastern Taiwan, at depths of 128 to 281 m. The discovery of
 this new species is significant in that it is the first confirmed, fully identified hermit crab known from hydrothermal vents,
 although the association of Paragiopagurus ventilatus with this environment does not appear to be «obligate». This new
 species is the 17th in the genus Paragiopagurus Lemaitre, 1996, and is distinguished primarily by the dense, long plumose
 setae with bacterial strands on the anterior sternal region, including outer surfaces of bases and ischia of third maxillipeds,
 and mesial and ventral surfaces of ischia and meri of the first three pereopods; striae on the ocular acicles; shape and arma-
 ture of the right cheliped; ventromesial armature of dactyls of second and third pereopods; and armature of anterior lobe of
 sternite XII.
(4073) Robert Kelso
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Étude comparative du cycle de reproduction de la palourde Ruditapes decussatus en milieu naturel (sud Tunisie) et contrôlé (écloserie)
Creators: name: HAMIDA, Leila
name: MEDHIOUBAND, Mohamed-Nejib
name: COCHARD, Jean Claude
name: ROMDHANE, Mohamed-Salah
name: LE PENNEC, Marcel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: A comparative study of the reproductive cycle of Ruditapes decussatus under natural (South of Tunisia) and con-
 trolled conditions (hatchery). The aim of this study was to describe and compare the gametogenic activity of Ruditapes
 decussatus in situ and in hatchery. Criteria of maturity were characterized and the positive role of conditioning in the suc-
 cess of artificial reproduction was underlined. Specimens sampled in the South of Tunisia were conditioned at the experi-
 mental station of Monastir (Tunisia). The parameters studied were the variation of the condition index and the frequency
 distribution of oocyte diameters. Results showed that the reproductive cycle was continuous in situ. Gametogenesis started
 in January and February. Gonadic activity increased from March to November–December. Spawning events occurred irre-
 gularly from June to December. In winter conditioning, mature oocytes were produced from March and spawning began in
 April. The increase in temperature and food abundance shortened the gametogenesis duration; ripe gametes were produced
 two months earlier compared to natural environment. In summer conditioning, the reproductive cycle was the same as that
 in the natural site, maturation and spawning occurred simultaneously.
Additional file 5 of Hamstrings force-length relationships and their implications for angle-specific joint torques: a narrative review
Creators: name: Kellis, Eleftherios
name: Blazevich, Anthony J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: Plasma Physics

description: Additional file 5 Title of data: Predicted peak hamstring moment-arm values. Description of data: Table displaying hip extension and knee flexion moment arm (MA) values (mm) of the hamstrings and angular position at which the maximum moment arm was observed, predicted using six models (see text for more details). Hip = hip extension angle (negative angle denotes hip extension, knee = knee flexion angle.
Service Use Patterns for Adolescents with ADHD and Comorbid Conduct Disorder
Creators: name: Foster, E. Michael
name: Greenberg, Mark T.
name: Coie, John D.
name: Pinderhughes, Ellen E.
name: Lochman, John E.
name: Bierman, Karen L.
name: Dodge, Kenneth A.
name: McMahon, Robert J.
name: Jones, Damon E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Service use patterns and costs of youth diagnosed with attention-deficit/hyperactivity disorder (ADHD) and comorbid conduct disorder (CD) were assessed across adolescence (ages 12 through 17). Featured service sectors include mental health, school services, and the juvenile justice system. Data are provided by three cohorts from the Fast Track evaluation and are based on parent report. Diagnostic groups are identified through a structured assessment. Results show that public costs for youth with ADHD exceed $40,000 per child on average over a 6-year period, more than doubling service expenditures for a non-ADHD group. Public costs for children with comorbid ADHD and CD double the costs of those with ADHD alone. Varying patterns by service sector, diagnosis, and across time indicate different needs for youth with different conditions and at different ages and can provide important information for prevention and treatment researchers.
Microwave magnetochiral effect in Cu2OSeO3
Creators: name: Mochizuki, Masahito
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We theoretically find that in a multiferroic chiral magnet Cu2OSeO3, resonant magnetic excitations are coupled to collective oscillation of electric polarization, and thereby attain simultaneous activity to ac magnetic field and ac electric field. Because of interference between these magnetic and electric activation processes, this material hosts gigantic magnetochiral dichroism on microwaves, that is, the directional dichroism at gigahertz frequencies in Faraday geometry. The absorption intensity of microwave differs by as much as 30% depending on whether its propagation direction is parallel or antiparallel to the external magnetic field.
description: 5 pages, 5 figures, accepted for publication in Physical Review Letters
The Role of Amino Acids in Extracellular Loops of the Human P2Y 1 Receptor in Surface Expression and Activation Processes
Creators: name: Hoffmann, Carsten
name: Moro, Stefano
name: Harden, T. Kendall
name: Nicholas, Robert A.
name: Jacobson, Kenneth A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The P2Y1 receptor is a membrane-bound G protein-coupled receptor stimulated by adenine nucleotides. Using alanine scanning mutagenesis, the role in receptor activation of charged amino acids (Asp, Glu, Lys, and Arg) and cysteines in the extracellular loops (EL) of the human P2Y1 receptor has been investigated. The mutant receptors were expressed in COS-7 cells and measured for stimulation of phospholipase C induced by the potent agonist 2-methylthioadenosine-5′-diphosphate (2-MeSADP). In addition to single point mutations, all receptors carried the hemagglutinin epitope at the N-terminus for detection of cell-surface expression. The C124A and C202A mutations, located near the exofacial end of transmembrane helix 3 and in EL2, respectively, ablated phospholipase C stimulation by ≤100 μM 2-MeSADP. Surface enzyme-linked immunosorbent assay detection of both mutant receptors showed <10% expression, suggesting that a critical disulfide bridge between EL2 and the upper part of transmembrane 3, as found in many other G protein-coupled receptors, is required for proper trafficking of the P2Y1 receptor to the cell surface. In contrast, the C42A and C296A mutant receptors (located in the N-terminal domain and EL3) were activated by 2-MeSADP, but the EC50 values were >1000-fold greater than for the wild-type receptor. The double mutant receptor C42A/C296A exhibited no additive shift in the concentration-response curve for 2-MeSADP. These data suggest that Cys42 and Cys296 form another disulfide bridge in the extracellular region, which is critical for activation. Replacement of charged amino acids produced only minor changes in receptor activation, with two remarkable exceptions. The E209A mutant receptor (EL2) exhibited a >1000-fold shift in EC50. However, if Glu209 were substituted with amino acids capable of hydrogen bonding (Asp, Gln, or Arg), the mutant receptors responded like the wild-type receptor. Arg287 in EL3 was impaired similarly to Glu209 when substituted by alanine. Substitution of Arg287 by lysine, another positively charged residue, failed to fully restore wild-type activity.
Bresilia antipodarumBruce, 1990 (Crustacea: Decapoda:Bresiliidae), a new record from New Caledonian waters
Creators: name: BRUCE, Alexander J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: Specimens of the bresiliid shrimp, Bresilia antipodarum Bruce, 1990 (Crustacea: Decapoda: Bresiliidae), have
 been collected for the second time only. The new record enables the description of the species to be augmented and indi-
 cates a considerable extension of its range, from off Tasmania to New Caledonia.
MPEC 2023-T241 : DAILY ORBIT UPDATE (2023 October 14)
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Une nouvelle espèce d'Urothoe, Urothoe atlantica (Crustacea: Amphipoda: Urothoidae) de la côte atlantique du Maroc
Creators: name: BELLAN-SANTINI, Denise
name: MENIOUI, Mohamed
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: A new species of Urothoe, U. atlantica (Crustacea: Amphipoda: Urothoidae) of the Marocco Atlantic coast.
 Urothoe atlantica sp. nov. was found in the south coast of Marocco. This new pecies is characterized by a pereiopod 5 with
 a large carpus and a third epimeral plate with a sinuous posterior side and a sharp point at its postero distal corner.
(4076) Jane Jeffrey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cladoplumaria anomalagen. nov., sp. nov., a new genus andspecies of the family Halopterididae (Cnidaria: Hydrozoa) from the Chesterfield Islands region (Pacific Ocean)
Creators: name: ANSÍN AGÍS, Jose A.
name: RAMIL, Francisco
name: VERVOORT, Willem
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: This paper is the first result of the study of large collections of Plumularioidea (Cnidaria, Hydrozoa, Leptolida)
 collected in the seas surrounding New Caledonia (Pacific Ocean) by French expeditions. A new genus of the family
 Halopterididae is described and its relations with other representatives of this family are discussed. The gonosome in its
 shape approaches the type of phylactocarp also met with in Aglaopheniidae; while the gonothecae (female with nematothe-
 cae and male without nematothecae) are nearer to those of the family Halopterididae.
Stability and Coalescence of Massive Twin Binaries
Creators: name: Hwang, Jason A.
name: Lombardi, James C.
name: Rasio, Frederic A.
name: Kalogera, Vassiliki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Massive stars are usually found in binaries, and binaries with periods less than 10 days may have a preference for near equal component masses. In this paper we investigate the evolution of these binaries all the way to contact and the possibility that these systems can be progenitors of double neutron star binaries. The small orbital separations of observed double neutron star binaries suggest that the progenitor systems underwent a common envelope phase at least once during their evolution. Bethe & Brown (1998) proposed that massive binary twins will undergo a common envelope evolution while both components are ascending the red giant branch or asymptotic giant branch simultaneously, also known as double-core evolution. Using models generated from the stellar evolution code Evolve Zero Age Main Sequence, we determine the range of mass ratios resulting in both components simultaneously ascending the RGB or AGB as a function of the difference in birth times, t. We find that, even for a generous t=5 Myr, the minimum mass ratio qmin=0.933 for an 8 Solar Mass primary and increases for larger primaries. We use a hydrodynamics code, StarSmasher, to study specifically the evolution of q=1 common envelope systems as a function of initial component mass, age, and orbital separation. We find the dynamical stability limit, the largest orbital separation where the binary becomes dynamically unstable, as a function of the component mass and age. Finally, we calculate the efficiency of ejecting matter during the inspiral phase to extrapolate the properties of the remnant binary from our numerical results, assuming the common envelope is completely ejected. We find that for the nominal core masses, there is a minimum orbital separation for a given component mass such that the helium cores survive common envelope evolution in a tightly bound binary and are viable progenitors for double neutron stars.
description: 51 pages, 26 figures, accepted for publication in ApJ
A Fast Hybrid Pressure-Correction Algorithm for Simulating Incompressible Flows by Projection Methods
Creators: name: Fang, Jiannong
Publisher: name: arXiv
Year: 2023
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: G.1.2; G.1.8
subject: 65M22, 76D05

description: For simulating incompressible flows by projection methods. it is generally accepted that the pressure-correction stage is the most time-consuming part of the flow solver. The objective of the present work is to develop a fast hybrid pressure-correction algorithm for numerical simulation of incompressible flows around obstacles in the context of projection methods. The key idea is to adopt different numerical methods/discretizations in the sub-steps of projection methods. Here, a classical second-order time-marching projection method which consists of two sub-steps is chosen for the purpose of demonstration. In the first sub-step, the momentum equations are discretized on unstructured grids and solved by conventional numerical methods, here, a meshless method. In the second sub-step (pressure-correction), the proposed algorithm adopts a double discretization system and combines the weighted least squares approximation with the essence of immersed boundary methods. Such a design allows us to develop a FFT-based solver to speed up the solution of the pressure Poisson equation for flow cases with obstacles, while keeping the implementation of boundary conditions for the momentum equations as easy as conventional numerical methods do with unstructured grids. Numerical experiments of five test cases have been performed to verify and validate the proposed hybrid algorithm and evaluate its computational performance. The results show that the new FFT-based hybrid algorithm is working and robust, and it is significantly faster than the multigrid-based reference method. The hybrid algorithm opens an avenue for the development of next-generation high-performance parallel computational fluid dynamics solvers for incompressible flows.
description: 40 pages, 21 figures
Single Cell Ras-GTP Analysis Reveals Altered Ras Activity in a Subpopulation of Neurofibroma Schwann Cells but Not Fibroblasts
Creators: name: Sherman, Larry S.
name: Cox, Adrienne D.
name: Ratner, Nancy
name: Atit, Radhika
name: Rosenbaum, Thorsten
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by multiple neurofibromas, peripheral nerve tumors containing mainly Schwann cells and fibroblasts. The NF1 gene encodes neurofibromin, a tumor suppressor postulated to function in part as a Ras GTPase-activating protein. The roles of different cell types and of elevated Ras-GTP in neurofibroma formation are unclear. To determine which neurofibroma cell type has altered Ras-GTP regulation, we developed an immunocytochemical assay for active, GTP-bound Ras. In NIH 3T3 cells, the assay detected overexpressed, constitutively activated K-, N-, and Ha-Ras and insulin-induced endogenous Ras-GTP. In dissociated neurofibroma cells from NF1 patients, Ras-GTP was elevated in Schwann cells but not fibroblasts. Twelve to 62% of tumor Schwann cells showed elevated Ras-GTP, unexpectedly revealing neurofibroma Schwann cell heterogeneity. Increased basal Ras-GTP did not correlate with increased cell proliferation. Normal human Schwann cells, however, did not demonstrate elevated basal Ras activity. Furthermore, compared with cells from wild type littermates, Ras-GTP was elevated in all mouse Nf1−/− Schwann cells but never in Nf1−/− mouse fibroblasts. Our results indicate that Ras activity is detectably increased in only some neurofibroma Schwann cells and suggest that neurofibromin is not an essential regulator of Ras activity in fibroblasts.
(4069) Alexander Robert Coldstream
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dilepton rate and quark number susceptibility with the Gribov action
Creators: name: Bandyopadhyay, Aritra
name: Haque, Najmul
name: Mustafa, Munshi G.
name: Strickland, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We use a recently obtained resummed quark propagator at finite temperature which takes into account both the chromoelectric scale gT and the chromomagnetic scale g^2T through the Gribov action. The electric scale generates two massive modes whereas the magnetic scale produces a new massless spacelike mode in the medium. Moreover, the non-perturbative quark propagator is found to contain no discontinuity in contrast to the standard perturbative hard thermal loop approach. Using this non-perturbative quark propagator and self-consistent vertices, we compute the non-perturbative dilepton rate at vanishing three-momentum at one-loop order. The resulting rate has a rich structure at low energies due to the inclusion of the non-perturbative magnetic scale. We also calculate the quark number susceptibility, which is related to the conserved quark number density fluctuation in the deconfined state. Both the dilepton rate and quark number susceptibility are compared with results from lattice quantum chromodynamics and the standard hard thermal loop approach. Finally, we discuss how the absence of a discontinuity in the imaginary part of the non-perturbative quark propagator makes the results for both dilepton production and quark number susceptibility dramatically different from those in perturbative approaches and seemingly in conflict with known lattice data.
description: 30 pages, 7 figures; v2 - version accepted for publication in PRD
Agonist Versus Antagonist Action of ATP at the P2Y 4 Receptor Is Determined by the Second Extracellular Loop
Creators: name: Harden, T. Kendall
name: Qi, Ai Dong
name: Nicholas, Robert A.
name: Herold, Christopher L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: UTP is a potent full agonist at both the human P2Y4 (hP2Y4) and rat P2Y4 (rP2Y4) receptor. In contrast, ATP is a potent full agonist at the rP2Y4 receptor but is a similarly potent competitive antagonist at the hP2Y4 receptor. To delineate the structural determinants of agonism versus antagonism in these species homologues, we expressed a series of human/rat P2Y4 receptor chimeras in 1321N1 human astrocytoma cells and assessed the capacity of ATP and UTP to mobilize intra-cellular Ca2+. Replacement of the NH2 terminus of the hP2Y4 receptor with the corresponding region of the rP2Y4 receptor resulted in a receptor that was activated weakly by ATP, whereas replacement of the second extracellular loop (EL2) of the hP2Y4 receptor with that of the rP2Y4 receptor yielded a chimeric receptor that was activated fully by UTP and near fully by ATP, albeit with lower potencies than those observed at the rP2Y4 receptor. These potencies were increased, and ATP was converted to a full agonist by replacing both the NH2 terminus and EL2 in the hP2Y4 receptor with the corresponding regions from the rP2Y4 receptor. Mutational analysis of the five divergent amino acids in EL2 between the two receptors revealed that three amino acids, Asn-177, Ile-183, and Leu-190, contribute to the capacity of EL2 to impart ATP agonism. Taken together, these results suggest that the second extracellular loop and the NH2 terminus form a functional motif that plays a key role in determining whether ATP functions as an agonist or antagonist at mammalian P2Y4 receptors.
(4070) John Coldstream
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nucleotide Release Provides a Mechanism for Airway Surface Liquid Homeostasis
Creators: name: Grubb, Barbara R.
name: Van Heusden, Catharina A.
name: Tarran, Robert
name: Lazarowski, Eduardo R.
name: Okada, Seiko
name: Boucher, Richard C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Nucleotides within the airway surface liquid (ASL) regulate airway epithelial ion transport rates by Ca2+- and protein kinase C-dependent mechanisms via activation of specific P2Y receptors. Extracellular adenine nucleotides also serve as precursors for adenosine, which promotes cyclic AMP-mediated activation of the cystic fibrosis transmembrane regulator chloride channel via A2b adenosine receptors. A biological role for extracellular ATP in ASL volume homeostasis has been suggested by the demonstration of regulated ATP release from airway epithelia. However, nucleotide hydrolysis at the airway surface makes it difficult to assess the magnitude of ATP release and the relative abundance of adenyl purines and, hence, to define their biological functions. We have combined ASL microsampling and high performance liquid chromatography analysis of fluorescent 1,N6-ethenoadenine derivatives to measure adenyl purines in ASL. We found that adenosine, AMP, and ADP accumulated in high concentrations relative to ATP within the ASL covering polarized primary human normal or cystic fibrosis airway epithelial cells. By using immortalized epithelial cell monolayers that endogenously express a luminal A2b adenosine receptor, we found that basal as well as forskolin-promoted cyclic AMP production was reduced by exogenous adenosine deaminase, suggesting that A2b receptors sense endogenous adenosine within the ASL. The physiological role of adenosine was further established by illustrating that adenosine removal or inhibition of adenosine receptors in primary cultures impaired ASL volume regulation. Our data reveal a complex pattern of nucleotides/nucleosides in ASL under resting conditions and suggest that adenosine may play a key role in regulating ASL volume homeostasis.
(4071) Margaret Drybrough Menzies
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
CUIDARIA AS FOOD-SOURCES FOR MARINE INVERTEBRATES
Creators: name: SALVINI-PLAWEN, Luitfried V.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1972

description: 1. A review of those representatives which—either as predators or as parasites—nourish themselves on Cnidaria, shows that the Coelenterates form a widespread source of food, and according to our knowledge there are neither systematic-anatomical nor ecological limits to exploit this resource in spite of the stingingnettle-weapons.
2.In comparing all these animals, the avoidance of the poisonous effect ofthe nematocysts seems to take place either by mechanical protection (cuticule lining of the pharynx, etc.) or by glandular action (of the integument or the gut).
3.As hyper-viscosity of the surrounding medium prevents the discharge ofnematocyts, most mucous and enzymatic secretions principally show an immunizing effect. The specificity of the predator’s secretion to the prey therefore would not need to be very profound, and the enormous number of cnidariavores would be explicable.
4.Some experimental findings and other evidence in Solenogastres (which have been dealt with in detail) as well as in Turbellaria and Gastropoda show that secretions of the gut, in reality, immunize the prey’s tissue before it is devoured.
ADDITIONS TO THE ROSCOFF MARINE FAUNA INVENTORY BASED ON OBSERVATIONS MADE 1977-87 IN THE BAY OF MORLAIX, WITH A REPORT ON 2 NEW SPECIES OF AMPHIPODS, AMPELISCA-SPOONERI DAUVIN-ET-BELLAN-SANTINI AND SCOPELOCHEIRUS-HOPEI COSTA
Creators: name: Dauvin, J. C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract
Structural Analysis of the Sulfotransferase (3- O -Sulfotransferase Isoform 3) Involved in the Biosynthesis of an Entry Receptor for Herpes Simplex Virus 1
Creators: name: Liu, Jian
name: Edavettal, Suzanne C.
name: Negishi, Masahiko
name: Moon, Andrea F.
name: Pedersen, Lars C.
name: Linhardt, Robert J.
name: Munoz, Eva M.
name: Krahn, Joe M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Heparan sulfate (HS) plays essential roles in assisting herpes simplex virus infection and other biological processes. The biosynthesis of HS includes numerous specialized sulfotransferases that generate a variety of sulfated saccharide sequences, conferring the selectivity of biological functions of HS. We report a structural study of human HS 3-O-sulfotransferase isoform 3 (3-OST-3), a key sulfotransferase that transfers a sulfuryl group to a specific glucosamine in HS generating an entry receptor for herpes simplex virus 1. We have obtained the crystal structure of 3-OST-3 at 1.95 Å in a ternary complex with 3′-phosphoadenosine 5′-phosphate and a tetrasaccharide substrate. Mutational analyses were also performed on the residues involved in the binding of the substrate. Residues Gln255 and Lys368 are essential for the sulfotransferase activity and lie within hydrogen bonding distances to the carboxyl and sulfo groups of the uronic acid unit. These residues participate in the substrate recognition of 3-OST-3. This structure provides atomic level evidence for delineating the substrate recognition and catalytic mechanism for 3-OST-3.
Permutations sortable by deques and by two stacks in parallel
Creators: name: Price, Andrew Elvey
name: Guttmann, Anthony J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05Axx

description: Recently Albert and Bousquet-Mélou \cite{AB15} obtained the solution to the long-standing problem of the number of permutations sortable by two stacks in parallel (tsip). Their solution was expressed in terms of functional equations. We show that the equally long-standing problem of the number of permutations sortable by a double-ended queue (deque) can be simply related to the solution of the same functional equations. Subject to plausible, but unproved, conditions, the radius of convergence of both generating functions is the same. Numerical work confirms this conjecture to 10 significant digits. Further numerical work suggests that the coefficients of the deque generating function behave as $κ_d \cdot μ^n \cdot n^{-3/2},$ where $μ= 8.281402207\ldots,$ while the coefficients of the corresponding tsip generating function behave as $κ_p \cdot μ^n \cdot n^γ$ with $γ\approx -2.473.$ The constants $κ_d$ and $κ_p$ are also estimated. {\em Inter alia,} we study the asymptotics of quarter-plane loops, starting and ending at the origin, with weight $a$ given to north-west and east-south turns. The critical point varies continuously with $a,$ while the corresponding exponent variation is found to be continuous and monotonic for $a > -1/2,$ but discontinuous at $a=-1/2.$
description: 31 pages, 8 figures, typos corrected, additional figures and references. Improved introduction and analysis. Aspects of proofs clarified
RELATIVE GROWTH AND SECONDARY PRODUCTION OF THE AMPHIPOD GAMMARUS-AEQUICAUDA (MARTYNOV, 1931) IN THE EVROS DELTA (N AEGEAN SEA)
Creators: name: Kevrekidis, T.
name: Lazaridoudimitriadou, M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract
(4072) John Robert Roxburgh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An Inhibitor of the F1 Subunit of ATP Synthase (IF1) Modulates the Activity of Angiostatin on the Endothelial Cell Surface
Creators: name: Pizzo, Salvatore V.
name: Kenan, Daniel J.
name: Fang, Jun
name: Capaldi, Roderick A.
name: Burwick, Nick R.
name: Moser, Tammy L.
name: Wahl, Miriam L.
name: Zhong, Zhaoxi
name: Li, Bo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Angiostatin binds to endothelial cell (EC)-surface F1-F0 ATP synthase, leading to inhibition of EC3 migration and proliferation during tumor angiogenesis. This has led to a search for angiostatin-mimetics specific for this enzyme. A naturally occurring protein that binds to the F1 subunit of ATP synthase and blocks ATP hydrolysis in mitochondria is Inhibitor of F1 (IF1). The present study explores the effect of IF1 on cell surface ATP synthase. IF1 protein bound to purified F1 ATP synthase and inhibited F1-dependent ATP hydrolysis consistent with its reported activity in studies of mitochondria. While exogenous IF1 did not inhibit ATP production on the surface of EC, it did conserve ATP on the cell surface, particularly at low extracellular pH. IF1 inhibited ATP hydrolysis but not ATP synthesis, in contrast to angiostatin, which inhibited both. In cell-based assays used to model angiogenesis in vitro, IF1 did not inhibit EC differentiation to form tubes and only slightly inhibited cell proliferation compared to angiostatin. From these data, we conclude that inhibition of ATP synthesis is necessary for an anti-angiogenic outcome in cell-based assays. We propose that IF1 is not an angiostatin-mimetic, but it can serve a protective role for EC in the tumor microenvironment. This protection may be overridden in a concentration-dependent manner by angiostatin. In support of this hypothesis, we demonstrate that angiostatin blocks IF1 binding to ATP synthase, and abolishes its ability to conserve ATP. These data suggest that there is a relationship between the binding sites of IF1 and angiostatin on ATP synthase and that IF1 could be employed to modulate angiogenesis.
Enzymatic Redesigning of Biologically Active Heparan Sulfate
Creators: name: Chen, Miao
name: Pedersen, Lars C.
name: McDowell, Lynda M.
name: Chen, Jinghua
name: Muñoz, Eva M.
name: Linhardt, Robert J.
name: Zhang, Lijuan
name: Liu, Jian
name: Avci, Fikri Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Heparan sulfate carries a wide range of biological activities, regulating blood coagulation, cell differentiation, and inflammatory responses. The sulfation patterns of the polysaccharide are essential for the biological activities. In this study, we report an enzymatic method for the sulfation of multimilligram amounts of heparan sulfate with specific functions using immobilized sulfotransferases combined with a 3′-phosphoadenosine 5′-phosphosulfate regeneration system. By selecting appropriate enzymatic modification steps, an inactive precursor has been converted to the heparan sulfate having three distinct biological activities, associated with binding to antithrombin, fibroblast growth factor-2, and herpes simplex virus envelope glycoprotein D. Because the recombinant sulfotransferases are expressed in bacteria, and the method uses a low cost sulfo donor, it can be readily utilized to synthesize large quantities of anticoagulant heparin drug or other biologically active heparan sulfates.
Security-Enhancing Digital Twins: Characteristics, Indicators, and Future Perspectives
Creators: name: Eckhart, Matthias
name: Ekelhart, Andreas
name: Allison, David
name: Almgren, Magnus
name: Ceesay-Seitz, Katharina
name: Janicke, Helge
name: Nadjm-Tehrani, Simin
name: Rashid, Awais
name: Yampolskiy, Mark
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: The term "digital twin" (DT) has become a key theme of the cyber-physical systems (CPSs) area, while remaining vaguely defined as a virtual replica of an entity. This article identifies DT characteristics essential for enhancing CPS security and discusses indicators to evaluate them.
description: \textcopyright 2023 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works
The structure and functioning of fish communities in the Riade Aveiro, Portugal  temporal and spatial variations and the influence of abiotic factors
Creators: name: POMBO, Lúcia
name: ELLIOTT, Mike
name: REBELO, José Eduardo
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: The ichthyofauna and environmental variables were sampled monthly over a 2-year period, from November 1998
 to October 2000, at 9 sites in the Ria de Aveiro, northern Portugal. Temperature, salinity, dissolved oxygen, pH and turbi-
 dity showed significant temporal variations, while salinity, pH, turbidity and depth showed significant spatial variations. A
 total of 41,681 individuals from 61 species were collected, with a total biomass of 222 Kg wet weight. Species richness
 was statistically higher in 1999 than in 2000, with peaks in spring-summer in both years, which could be attributed to an
 influx of marine seasonal migrant species and marine juvenile species. Diversity and evenness were significantly higher in
 1999 than 2000 with peaks in spring and autumn and low values in June for the first year, and in February and November
 for the second year and corresponding to the large recruitment of adult marine seasonal and adventitious species. Spatially,
 both indices were higher at the intermediate regions of the lagoon. Salinity was found to be the best predictor of total bio-
 mass, with temperature also having a major role. Temperature, salinity and pH were positively correlated with species rich-
 ness and depth was negatively correlated with species richness. It is concluded that the abiotic factors were related to the
 distribution and diversity of the ichthyofauna such that seasonal changes in abiotic factors appeared to be of greater impor-
 tance in explaining variations in the fish communities than location within the lagoon.
Additional file 1 of Potential benefits of a virtual, home-based combined exercise and mindfulness training program for HSC transplant survivors: a single-arm pilot study
Creators: name: Ma, David D. F.
name: Fennessy, Kate
name: Kliman, David
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Additional trial details including orientation session, exercise and MBSM interventions, outcome assessments and hand strength dynamometer calibration.
Alcoholic beverages as a food and their relation to nutrition (Lay supplement No. 8)
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1942

description: Jellinek, E. M. (1942). Alcoholic beverages as a food and their relation to nutrition (Lay supplement No. 8). New Haven, CT: Journal of Studies on Alcohol, Inc.
The first records of Megalomma lanigera (Polychaeta: Sabellidae) from British waters
Creators: name: WASSON, Bryan
name: SHEEHAN, Emma
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Megalomma lanigera is recorded for the first time in British waters. Specimens were discovered during a 2012/2013 benthic study of maerl beds in Falmouth Harbour in Cornwall.
Second Order Transport Coefficient from Chiral Anomaly at Weak Coupling: Diagrammatic Resummation
Creators: name: Jimenez-Alba, Amadeo
name: Yee, Ho-Ung
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We compute one of the second order transport coefficients arising from the chiral anomaly in a high temperature weakly coupled regime of quark-gluon plasma. This transport coefficient is responsible for the CP-odd current that is proportional to the time derivative of the magnetic field, and can be considered as a first correction to the chiral magnetic conductivity at finite, small frequency. We observe that this transport coefficient has a non-analytic dependence on the coupling as $\sim 1/(g^4 \log(1/g))$ at weak coupling regime, which necessitates a re-summation of infinite ladder diagrams with leading pinch singularities to get a correct leading log result: a feature quite similar to that one finds in the computation of electric conductivity. We formulate and solve the relevant CP-odd Schwinger-Dyson equation in real-time perturbation theory that reduces to a coupled set of second order differential equations at leading log order. Our result for this second order transport coefficient indicates that chiral magnetic current has some resistance to the time change of magnetic field, which may be called "chiral induction effect". We also discuss the case of color current induced by color magnetic field.
description: 54 pages, 8 figures
Additional file 2 of Potential benefits of a virtual, home-based combined exercise and mindfulness training program for HSC transplant survivors: a single-arm pilot study
Creators: name: Ma, David D. F.
name: Fennessy, Kate
name: Kliman, David
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Completed TIDier checklist with details of study interventions.