cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Professional self-understanding of teachers in different career stages: a phenomenological analysis
Creators: name: Yağan, Ersin
name: Özgenel, Mustafa
name: Baydar, Fatih
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Interview Transcripts with Teachers.
Text S1: Details on Robofish design and features from Using a robotic fish to investigate individual differences in social responsiveness in the guppy
Creators: name: Bierbach, David
name: Landgraf, Tim
name: Romanczuk, Pawel
name: Lukas, Juliane
name: Nguyen, Hai
name: Wolf, Max
name: Krause, Jens
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences

description: Responding towards the actions of others is one of the most important behavioural traits whenever animals of the same species interact. Mutual influences among interacting individuals may modulate the social responsiveness seen and thus make it often difficult to study the level and individual variation in responsiveness. Here, open-loop biomimetic robots that provide standardized, non-interactive social cues can be a useful tool. These robots are not affected by the live animal's actions but are assumed to still represent valuable and biologically relevant social cues. As this assumption is crucial for the use of biomimetic robots in behavioural studies, we hypothesized (i) that meaningful social interactions can be assumed if live animals maintain individual differences in responsiveness when interacting with both a biomimetic robot and a live partner. Furthermore, to study the level of individual variation in social responsiveness, we hypothesized (ii) that individual differences should be maintained over the course of multiple tests with the robot. We investigated the response of live guppies (Poecilia reticulata) when allowed to interact either with a biomimetic open-loop-controlled fish robot—‘Robofish’—or with a live companion. Furthermore, we investigated the responses of live guppies when tested three times with Robofish. We found that responses of live guppies towards Robofish were weaker compared with those of a live companion, most likely as a result of the non-interactive open-loop behaviour of Robofish. Guppies, however, were consistent in their individual responses between a live companion and Robofish, and similar individual differences in response towards Robofish were maintained over repeated testing even though habituation to the test environment was detectable. Biomimetic robots like Robofish are therefore a useful tool for the study of social responsiveness in guppies and possibly other small fish species.
Biochemical Characterization of the Human Cyclin-dependent Protein Kinase Activating Kinase: IDENTIFICATION OF p35 AS A NOVEL REGULATORY SUBUNIT
Creators: name: Wu, Lingtao
name: Kobayashi, Ryuji
name: Xiong, Yue
name: Yee, Ann
name: Hall, Frederick L.
name: Liu, Ling
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The activation of cyclin-dependent protein kinases (Cdks) is dependent upon site-specific phosphorylation and dephosphorylation reactions, as well as positive and negative regulatory subunits. The human Cdk-activating protein kinase (Cak1) is itself a Cdc2-related cyclin-dependent protein kinase that associates with cyclin H. The present study utilized specific anti-Cak1 antibodies and immunoaffinity chromatography to identify additional Cak1-associated proteins and potential target substrates. Immunoprecipitation of metabolically labeled human osteosarcoma cells revealed a number of Cak1-associated proteins, including p95, p37 (cyclin H), and a 35-kDa protein that was further characterized herein. Microsequence analysis obtained after limited proteolysis revealed peptide fragments that are similar, but not identical to, human and yeast cyclins, thus identifying p35 as a cyclin-like regulatory subunit. The greatest sequence similarity of human p35 is with Mcs2, a yeast cyclin that is essential for cell cycle progression. Immunoaffinity chromatography performed under nondenaturing conditions afforded the isolation of enzymatically active Cak1 from cell lysates, enabling studies of kinase autophosphorylation and comparative substrate utilization. Immunoaffinity-purified Cak1 phosphorylated monomeric Cdc2 and Cdk2, but not Cdk4; the phosphorylation of both Cdc2 and Cdk2 were increased in the presence of recombinant cyclin A. These studies indicate that the Cak1 catalytic subunit, like Cdc2 and Cdk2, associates with multiple regulatory partners and suggests that subunit composition may be an important determinant of this multifunctional enzyme.
Text S2: Calculation of average time-delayed cross-correlation (TLXC) from Using a robotic fish to investigate individual differences in social responsiveness in the guppy
Creators: name: Bierbach, David
name: Landgraf, Tim
name: Romanczuk, Pawel
name: Lukas, Juliane
name: Nguyen, Hai
name: Wolf, Max
name: Krause, Jens
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 30402 Biomolecular Modelling and Design
subject: FOS: Chemical sciences

description: Responding towards the actions of others is one of the most important behavioural traits whenever animals of the same species interact. Mutual influences among interacting individuals may modulate the social responsiveness seen and thus make it often difficult to study the level and individual variation in responsiveness. Here, open-loop biomimetic robots that provide standardized, non-interactive social cues can be a useful tool. These robots are not affected by the live animal's actions but are assumed to still represent valuable and biologically relevant social cues. As this assumption is crucial for the use of biomimetic robots in behavioural studies, we hypothesized (i) that meaningful social interactions can be assumed if live animals maintain individual differences in responsiveness when interacting with both a biomimetic robot and a live partner. Furthermore, to study the level of individual variation in social responsiveness, we hypothesized (ii) that individual differences should be maintained over the course of multiple tests with the robot. We investigated the response of live guppies (Poecilia reticulata) when allowed to interact either with a biomimetic open-loop-controlled fish robot—‘Robofish’—or with a live companion. Furthermore, we investigated the responses of live guppies when tested three times with Robofish. We found that responses of live guppies towards Robofish were weaker compared with those of a live companion, most likely as a result of the non-interactive open-loop behaviour of Robofish. Guppies, however, were consistent in their individual responses between a live companion and Robofish, and similar individual differences in response towards Robofish were maintained over repeated testing even though habituation to the test environment was detectable. Biomimetic robots like Robofish are therefore a useful tool for the study of social responsiveness in guppies and possibly other small fish species.
(2029) Samuel Wood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cellular Internalization and Degradation of Antithrombin III-Thrombin, Heparin Cofactor II-Thrombin, and -Antitrypsin-Trypsin Complexes Is Mediated by the Low Density Lipoprotein Receptor-related Protein
Creators: name: Church, Frank C.
name: Argraves, W. Scott
name: Kounnas, Maria Z.
name: Strickland, Dudley K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The inhibition of proteinase activity by members of the serine proteinase inhibitor (serpin) family is a critical regulatory mechanism for a variety of biological processes. Once formed, the serpin enzyme complexes (SECs) are removed from the circulation by a hepatic receptor. The present study suggests that this receptor is very likely the low density lipoprotein receptor-related protein (LRP), a prominent liver receptor. In vitro binding studies revealed that antithrombin III (ATIII)-thrombin, heparin cofactor II (HCII)-thrombin, and alpha1-antitrypsin (alpha1AT)-trypsin bound to purified LRP, and their binding was inhibited by the 39-kDa receptor-associated protein (RAP), an antagonist of LRP-ligand binding activity. In contrast, native or modified forms of the inhibitors were unable to bind to LRP. Mouse embryonic fibroblasts, which express LRP, mediate the cellular internalization leading to degradation of these SECs, while mouse fibroblasts genetically deficient in LRP showed no capacity to internalize and degrade these complexes. SECs were also degraded by HepG2 cells, and this process was inhibited by LRP antibodies, RAP, and chloroquine. The cellular-mediated uptake and degradation was specific for SECs; native or modified forms of the inhibitors were not internalized and degraded. Finally, in vivo clearance studies in rats demonstrated that RAP inhibited the clearance of ATIII-125I-thrombin complexes from the circulation. Together, these results indicate that LRP functions as a liver receptor responsible for the plasma clearance of SECs.
Comparison of the unit cell from Cuticle network and orientation preference of photonic crystals in the scales of the weevil Lamprocyphus augustus.
Creators: name: R. Ebihara
name: H. Hashimoto
name: J. Kano
name: T. Fujii
name: S. Yoshioka
Publisher: name: The Royal Society
Year: 2018
Subjects: Biophysics

description: Comparison of the unit cell structure between the theory (left) and experiment (right).
(2025) Thomas Clarke Kitchin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Characterization of a Ku86 Variant Protein That Results in Altered DNA Binding and Diminished DNA-dependent Protein Kinase Activity
Creators: name: Carter, Timothy
name: Wyche, James H.
name: Johnston, Christine
name: Reeves, Westley H.
name: Han, Zhiyong
name: Hendrickson, Eric A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Three proteins known to play a critical role in mammalian DNA double-strand break repair and lymphoid V(D)J recombination are the autoantigens Ku86 and Ku70 and a 465-kDa serine/threonine protein kinase catalytic subunit (DNA-PKcs). These proteins physically associate to form a complex (DNA.PK) with DNA-dependent protein kinase activity. In this study, we demonstrate using electrophoretic mobility shift assays (EMSAs) that the nuclear DNA end-binding activity of Ku is altered in the human promyelocytic leukemic HL-60 cell line. Western blot and EMSA supershift analyses revealed that HL-60 cells expressed both full-length and variant Ku86 proteins. However, a combined EMSA and immunoanalysis revealed that the Ku heterodimers complexed with DNA in HL-60 cells contained only the variant Ku86 proteins. Finally, UV cross-linking experiments and DNA.PK assays demonstrated that the Ku complexes containing variant Ku86 had a greatly reduced ability to interact with DNA-PKcs and that consequently HL-60 cells had severely diminished DNA.K activity. These data provide important insights into the interaction between Ku and DNA-PKcs and into the role of DNA.PK in DNA double-strand break repair.
The American Soldier in World War II: Attitudes Toward Army Life
Creators: name: Research Branch, Information
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Rank in military; state in which respondent spend last five years of civilian life; length in military; length of time serviced in the British Isles; branch of army; stay in army after war; drafting men into the military; military training; morals of men in company; pride in company; high/low spirits in military; worthwhile being in military; fighting in war; best fit military occupation for respondent; officer/enlisted men relations; better/worse situation at home for friends/family; hardest country to win war against; length of war; best way to keep out of war in future; future after the war; future of soldiers after war; soldiers given first choice of jobs after war; personal stake in war; soldiers understand why US is fighting war; military weekly discussion groups; respondent's knowledge of recent events/news; source of news; listen to radio; opinion of Great Britain/British people.
Characterization of the Mouse Epidermal Growth Factor Promoter and 5′-Flanking Region: ROLE FOR AN ATYPICAL TATA SEQUENCE
Creators: name: Fenton, Suzanne E.
name: Groce, Natalie S.
name: Lee, David C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: As a step toward delineating mechanisms that regulate its activity, we have characterized the mouse epidermal growth factor (EGF) promoter. Primer extension and S1 nuclease analyses identified prominent (+1/+2) and minor (+28) transcription start sites, with the dominant +1/+2 site located 33 bases downstream from a TTTAAA sequence. A restriction fragment that spanned these start sites and contained 390 base pairs of 5'-flanking sequence directed transcription from the +1/+2 site in vitro in the presence of HeLa cell nuclear extracts. Additionally, it promoted expression of a coupled luciferase reporter gene in transfected cell lines. The inclusion of additional 5'-flanking sequence either stimulated or inhibited luciferase expression depending on the cell line. Approximately 2 kilobases of EGF 5'-flanking sequence was determined and found to contain several motifs with partial homology to steroid hormone response elements. Despite this fact and evidence that EGF expression might be regulated by androgens in vivo, EGF promoter-luciferase constructs were not steroid-responsive in cells cotransfected with steroid receptor expression vectors. An oligonucleotide containing the aforementioned TTTAAA sequence specifically bound TATA-binding protein and TFIIA in gel shift assays, and an EGF promoter-luciferase construct in which the core TA dinucleotide was mutated to CG was not active in transfected cells. These data suggest that the TTTAAA sequence functions as an atypical TATA box.
The American Soldier in World War II: Attitudes in the China-India-Burma Theater
Creators: name: Research Branch, Information
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Rank in military; state in which respondent spend last five years of civilian life; entered military by draft/volunteered/national guard; length of time in military; length of time in China-Burma-India theater; branch of army; officers in company; officers have a personal interest in soldiers; combat experience; military equipment; military occupation; occupation after the war; education; back to school after war; correspondence courses; future situations after war; best way for US to stay out of future war; release soldiers from military; soldiers given first choice of jobs after war; volunteer soldiers only; draft soldiers; military training; foreign countries cooperation after war; good fighters in specific foreign countries; view of foreign countries; Newsmap; recent news events; understanding of why US is in war; knowledge of recent news events; interest in fighting; discussion about war; 'Four Freedoms'; effort in beating Germany/Japan in war; war department films.
Characterization of Three Rice Basic/Leucine Zipper Factors, Including Two Inhibitors of EmBP-1 DNA Binding Activity
Creators: name: Nantel, André
name: Quatrano, Ralph S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The promoter of the wheat Em gene contains elements with a CACGTG core sequence (G-boxes), which are recognized by EmBP-1, a wheat basic/leucine zipper (bZIP) protein. G-boxes are required for Em expression in response to the phytohormone abscisic acid and for transactivation by the Viviparous-1 protein (VP1) using transient expression systems. In order to identify other factors that are part of the transcriptional complex that associates with G-boxes, we have screened a rice (Oryza sativa) cDNA library with biotinylated EmBP-1. We have isolated osZIP-1a, a homolog of EmBP-1 and other plant G-box-binding factors. We show that EmBP-1 and osZIP-1a will preferentially heterodimerize in vitro. Overexpression of osZIP-1a in rice protoplasts can enhance expression from the Em promoter only in the presence of abscisic acid. Two other clones have been identified by screening with EmBP-1: osZIP-2a and osZIP-2b. These osZIP-2 factors represent a novel class of bZIP proteins with an unusual DNA-binding domain that does not recognize G-boxes. The osZIP-2 factors can heterodimerize with EmBP-1 and prevent it from binding to the Em promoter. Interestingly, osZIP-1a does not heterodimerize with the osZIP-2 factors and its DNA binding activity is unaffected by their presence. Thus, osZIP-2 factors may be involved in sequestering a particular group of G-box-binding factors into inactive heterodimers.
Comparison of the unit cell from Cuticle network and orientation preference of photonic crystals in the scales of the weevil Lamprocyphus augustus
Creators: name: R. Ebihara
name: H. Hashimoto
name: J. Kano
name: T. Fujii
name: S. Yoshioka
Publisher: name: The Royal Society
Year: 2018
Subjects: Biophysics

description: Comparison of the unit cell structure between the theory (left) and experiment (right).
Backward stochastic differential equations with regime-switching and sublinear expectations
Creators: name: Vega, Engel John C. Dela
name: Elliott, Robert J.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H10 (Primary) 60J28 (Secondary)

description: This paper introduces a backward stochastic differential equation driven by both Brownian motion and a Markov chain (BSDEBM). Regime-switching is also incorporated through its driver. The existence and uniqueness of the solution of the BSDEBM are proved. A comparison theorem is also derived. Filtration consistent sublinear expectations are defined and characterized as solutions to the BSDEBM. The bid and ask prices are then represented using sublinear expectations.
description: 19 pages
Supplemental document from Simulation of the nodal flow of mutant embryos with a small number of cilia: comparison of mechanosensing and vesicle transport hypotheses.
Creators: name: Omori, Toshihiro
name: Winter, Katja
name: Shinohara, Kyosuke
name: Hamada, Hiroshi
name: Ishikawa, Takuji
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Left–right (L-R) asymmetry in the body plan is determined by nodal flow in vertebrate embryos. (Shinohara K et al. 2012 Nat. Commun. 3, 622 (doi:10.1038/ncomms1624)) Shinohara et al. used Dpcd and Rfx3 mutant mouse embryos and showed that only a few cilia were sufficient to achieve L-R asymmetry. However, the mechanism underlying the breaking of symmetry by such weak ciliary flow is unclear. Flow-mediated signals associated with the L-R asymmetric organogenesis have not been clarified, and two different hypotheses'—vesicle transport and mechanosensing—are now debated in the research field of developmental biology. In this study, we developed a computational model of the node system reported by Shinohara et al. and examined the feasibilities of the two hypotheses with a small number of cilia. With the small number of rotating cilia, flow was induced locally and global strong flow was not observed in the node. Particles were then effectively transported only when they were close to the cilia, and particle transport was strongly dependent on the ciliary positions. Although the maximum wall shear rate was also influenced by ciliary position, the mean wall shear rate at the perinodal wall increased monotonically with the number of cilia. We also investigated the membrane tension of immotile cilia, which is relevant to the regulation of mechanotransduction. The results indicated that tension of at about 0.1 μN m−1 was exerted at the base even when the fluid shear rate was applied about 0.1 s−1. The area of high tension was also localized at the upstream side, and negative tension appeared at the downstream side. Such localization may be useful to sense the flow direction at the periphery, as time-averaged anticlockwise circulation was induced in the node by rotation of a few cilia. Our numerical results support the mechanosensing hypothesis, and we expect that our study will stimulate further experimental investigations of mechanotransduction in the near future.
Dissecting Clot Retraction and Platelet Aggregation: CLOT RETRACTION DOES NOT REQUIRE AN INTACT FIBRINOGEN CHAIN C TERMINUS
Creators: name: Parise, Leslie V.
name: Lord, Susan T.
name: Rooney, Michael M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Fibrinogen mediates the processes of platelet aggregation and clot retraction. Previous studies have demonstrated that fibrinogen binding to the platelet receptor alphaIIbbeta3 requires the C-terminal residues of the fibrinogen gamma chain. We made a recombinant human fibrinogen that lacks the gamma chain C-terminal four residues (AGDV). As expected this fibrinogen did not support platelet aggregation. Unexpectedly, this variant did support clot retraction that was indistinguishable from retraction with normal recombinant or plasma fibrinogen. These results suggest that the site on fibrinogen that is required for platelet aggregation differs from the site on fibrin that is required for clot retraction.
(2024) James Dufton Kitchin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Drosophila α-Catenin and E-cadherin Bind to Distinct Regions of Drosophila Armadillo
Creators: name: Peifer, M.
name: Pai, L. M.
name: Takeichi, M.
name: Kirkpatrick, C.
name: Blanton, J.
name: Oda, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Adherens junctions are multiprotein complexes mediating cell-cell adhesion and communication. They are organized around a transmembrane cadherin, which binds a set of cytoplasmic proteins required for adhesion and to link the complex to the actin cytoskeleton. Three components of Drosophila adherens junctions, analogous to those in vertebrates, have been identified: Armadillo (homolog of beta-catenin), Drosophila E-cadherin (DE-cadherin), and alpha-catenin. We carried out the first analysis of the interactions between these proteins using in vitro binding assays, the yeast two-hybrid system, and in vivo assays. We identified a 76-amino acid region of Armadillo that is necessary and sufficient for binding alpha-catenin and found that the N-terminal 258 amino acids of alpha-catenin interact with Armadillo. A large region of Armadillo, spanning six central Armadillo repeats, is required for DE-cadherin binding, whereas only 41 amino acids of the DE-cadherin cytoplasmic tail are sufficient for Armadillo binding. Our data complement and extend results obtained in studies of vertebrate adherens junctions, providing a foundation for understanding how junctional proteins assemble and a basis for interpreting existing mutations and creating new ones.
Expression Cloning of lsc , a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors
Creators: name: Kayt, Robert
name: Khosravi-Far, Roya
name: Der, Channing J.
name: Trigo-Gonzalez, Genny
name: Kirk, Heather
name: Whitehead, Ian P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: In a screen for genes with oncogenic potential expressed by the murine B6SUtA1 myeloid progenitor cell line, we isolated a 2. 5-kilobase pair cDNA whose expression causes strong morphological transformation and deregulated proliferation of NIH 3T3 cells. The transforming cDNA encodes a truncated protein (designated Lsc) with a region of sequence similarity to the product of the lbc oncogene. This region includes the tandem Dbl homology and pleckstrin homology domains that are hallmarks of the Dbl-like proteins, a family of presumptive or demonstrated guanine nucleotide exchange factors that act on Rho family GTPases. Lsc requires intact Dbl homology and pleckstrin homology domains for its oncogenic activity. The transforming activity of Lsc in NIH 3T3 cells is reduced by cotransfection with p190 (a GTPase activating protein for Rho family GTPases) and the Rho family dominant-negative mutants RhoA(19N), CDC42(17N), and Rac1(17N). These results indicate a role for the Rho family of GTPases in mediating the transforming activity of Lsc and are consistent with the exchange specificities that have been attributed to Dbl family members. The lsc gene is expressed in a variety of tissues and is particularly abundant in hemopoietic tissues (thymus, spleen, and bone marrow). Lsc is a member of a growing family of proteins that may function as activators of Rho family GTPases in a developmental or tissue-specific manner.
Quantum algorithms for the generalized eigenvalue problem
Creators: name: Liang, Jin-Min
name: Shen, Shu-Qian
name: Li, Ming
name: Fei, Shao-Ming
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The generalized eigenvalue (GE) problems are of particular importance in various areas of science engineering and machine learning. We present a variational quantum algorithm for finding the desired generalized eigenvalue of the GE problem, $\mathcal{A}|ψ\rangle=λ\mathcal{B}|ψ\rangle$, by choosing suitable loss functions. Our approach imposes the superposition of the trial state and the obtained eigenvectors with respect to the weighting matrix $\mathcal{B}$ on the Rayleigh-quotient. Furthermore, both the values and derivatives of the loss functions can be calculated on near-term quantum devices with shallow quantum circuit. Finally, we propose a full quantum generalized eigensolver (FQGE) to calculate the minimal generalized eigenvalue with quantum gradient descent algorithm. As a demonstration of the principle, we numerically implement our algorithms to conduct a 2-qubit simulation and successfully find the generalized eigenvalues of the matrix pencil $(\mathcal{A},\,\mathcal{B})$. The numerically experimental result indicates that FQGE is robust under Gaussian noise.
title: Perturbative analysis of operators under improved gradient flow in lattice QCD
Creators: name: Stendebach, Simon
Publisher: name: UNSPECIFIED
Year: 2023

description: Quantum Chromodynamics, the study of quarks, gluons and their interaction, is a field yet to be fully understood. The strength of the coupling makes perturbative predictions less reliable than those of weakly coupled Quantum Electrodynamics. Therefore, based on the path integral formalism, lattice calculations were introduced and proven to be a powerful tool. However, the numerical results come with systematic deviations from the physical world that make it hard to extrapolate to the continuum limit. These can be reduced by choosing the lattice action and observable cleverly. Furthermore, lattice results are often very noisy, again making it hard to extract information. Gradient flow has proven to be a useful tool to resolve this problem. Its lattice formulation again suffers from systematic deviations that can be reduced via a more elaborate definition, the Zeuthen flow. In lattice studies, this improved gradient flow is used to measure color-electric as well as color-magnetic correlators which are expectation values of components of the QCD gauge field strength tensor. They contain information about propagation of heavy quarks in the quark-gluon plasma. Lattice perturbation theory is used in this work to derive their leading order behaviour which allows for easier extrapolation to the continuum and zero flow. In addition, the action density which can be used to measure the gauge coupling on the lattice is expanded in the lattice spacing for various combinations of action, flow and operator to both simplify continuum extrapolation and to see which combinations are to be preferred.
(2020) William Humble
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Local zeta regularization and the scalar Casimir effect III. The case with a background harmonic potential
Creators: name: Fermi, Davide
name: Pizzocchero, Livio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81T55, 83C47

description: Applying the general framework for local zeta regularization proposed in Part I of this series of papers, we renormalize the vacuum expectation value of the stress-energy tensor (and of the total energy) for a scalar field in presence of an external harmonic potential.
description: Some overlaps with our works arXiv:1104.4330, arXiv:1505.00711, arXiv:1505.01044, arXiv:1505.03276. These overlaps aim to make the present paper self-contained, and do not involve the main results
Additional file 1 of Network characteristics of a referral system for patients with hypertension in Western Kenya: results from the Strengthening Referral Networks for Management of Hypertension Across the Health System (STRENGTHS) study
Creators: name: Thakkar, Aarti
name: Valente, Thomas
name: Andesia, Josephine
name: Njuguna, Benson
name: Miheso, Juliet
name: Mercer, Tim
name: Mugo, Richard
name: Mwangi, Ann
name: Mwangi, Eunice
name: Pastakia, Sonak D.
name: Pathak, Shravani
name: Pillsbury, Mc Kinsey M.
name: Kamano, Jemima
name: Naanyu, Violet
name: Williams, Makeda
name: Vedanthan, Rajesh
name: Akwanalo, Constantine
name: Bloomfield, Gerald S.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1. STRENGTHS Referral Network Survey.
(2022) James Kitchin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Expression of the Three Alternative Forms of the Sphingolipid Activator Protein Precursor in Baby Hamster Kidney Cells and Functional Assays in a Cell Culture System
Creators: name: Suziki, Kunihiko
name: Glombitza, Gereon J.
name: Henseler, Margarete
name: Klein, Andreas
name: Sandhoff, Konrad
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Sphingolipid activator proteins (SAPs) are non-enzymatic glycoproteins required for lysosomal degradation of various sphingolipids with short oligosaccharide chains by their respective exohydrolases. Four of these (SAP-A to SAP-D or saposins A to D) are derived from a common precursor by proteolytic processing. Alternative splicing of the SAP-precursor gene results in insertion of additional 6 or 9 bases of exon 8' or 8, respectively, into the SAP-B coding region of the transcribed mRNAs. To examine the features of the three different SAP-precursor proteins (prosaposins), the respective cDNAs were stably expressed in baby hamster kidney cells. Pulse-chase experiments with transfected cells and endocytosis studies on human fibroblasts showed that synthesis, transport, and maturation of all SAP-precursor led to formation of the four mature SAPs (SAP-A to SAP-D). In order to determine the biological function of the three different SAP-B isoforms, SAP-precursor-deficient human fibroblasts were loaded with recombinant SAP-precursor proteins with or without 2- and 3-amino acid insertions, respectively, purified from the medium of the baby hamster kidney cells. They were found to stimulate at nanomolar concentrations the turnover of biosynthetically labeled ceramide, glucosylceramide, and lactosylceramide. Since the physiological function of SAP-B is to stimulate the degradation of sulfatide by arylsulfatase A (EC 3.1.6.1) and globotriaosylceramide by beta-galactosidase (EC 3.2.1.23) loading studies with the respective exogenously labeled lipids on SAP-precursor-deficient fibroblasts were performed. Addition of different purified SAP-precursors to the medium of the lipid-loaded fibroblasts showed positive stimulation of the lipid degradation by all three SAP-B isoforms derived from the SAP-precursors. These findings establish that all three forms of the SAP-B can function as sulfatide/globotriaosylceramide activator.
Rolf Geffken: Arbeit in China - Arbeit, Arbeitsbeziehungen und Arbeitsrecht in der VR China, Taiwan und Hongkong
Creators: name: Bornemann, Jan
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2022

description: ASIEN: The German Journal on Contemporary Asia, Nr. 95 (2005): ASIEN (April)
Supplemental document from Simulation of the nodal flow of mutant embryos with small number of cilia: comparison of mechanosensing and vesicle transport hypotheses
Creators: name: Omori, Toshihiro
name: Winter, Katja
name: Shinohara, Kyosuke
name: Hamada, Hiroshi
name: Ishikawa, Takuji
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Left-right (L-R) asymmetry in the body plan is determined by nodal flow in vertebrate embryos. Shinohara et al. used Dpcd and Rfx3 mutant mouse embryos and showed that only a few cilia were sufficient to achieve L-R asymmetry. However, the mechanism underlying the breaking of symmetry by such weak ciliary flow is unclear. Flow-mediated signals associated with the L-R asymmetric organogenesis have not been clarified, and two different hypotheses' vesicle transport and mechanosensing are now debated in the research field of developmental biology. In this study, we developed a computational model of the node system reported by Shinohara et al. and examined feasibilities of two hypotheses with a small number of cilia. With the small number of rotating cilia, flow was induced locally and global strong flow was not observed in the node. Particles were then effectively transported only when they were close to the cilia, and particle transport was strongly dependent on the ciliary positions. Although the maximum wall shear rate was also influenced by ciliary position, the mean wall shear rate at the perinodal wall increased monotonically with the number of cilia. We also investigated the membrane tension of immotile cilia, which is relevant to the regulation of mechanotransduction. The results indicated that tension of about 0.1 μN m−1 was exerted at the base even when the fluid shear rate was applied about 0.1 s−1. The area of high tension was also localized at the upstream side, and negative tension appeared at the downstream side. Such localization may be useful to sense the flow direction at the periphery, as time-averaged anticlockwise circulation was induced in the node by rotation of a few cilia. Our numerical results support the mechanosensing hypothesis, and we expect that our study will stimulate further experimental investigations of mechanotransduction in the near future.
Driving magnetic skyrmions with microwave fields
Creators: name: Wang, Weiwei
name: Beg, Marijan
name: Zhang, Bin
name: Kuch, Wolfgang
name: Fangohr, Hans
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We show theoretically by numerically solving the Landau-Lifshitz-Gilbert equation with a classical spin model on a two-dimensional system that both magnetic skyrmions and skyrmion lattices can be moved with microwave magnetic fields. The mechanism is enabled by breaking the axial symmetry of the skyrmion, for example through application of a static in-plane external field. The net velocity of the skyrmion depends on the frequency and amplitude of the microwave fields as well as the strength of the in-plane field. The maximum velocity is found where the frequency of the microwave coincides with the resonance frequency of the breathing mode of the skyrmions.
The American Soldier in World War II: Attitudes in the China-India-Burma Theater
Creators: name: Research Branch, Information
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Rank in military; state in which respondent spend last five years of civilian life; entered military by draft/volunteered/national guard; length of time in national guard; importance of China-Burma-India theater in war effort; branch of army; military training; pride in company; interest in military occupation; military occupation; worthwhile being in military; make good in military; good/bad time while in military; importance of military occupation in war effort; low/high spirits while in military; worried/upset while in military; overseas combat v.s. overseas non-combat duty v.s. US duty; soldiers v.s. working a war job; satisfaction of military occupation; officer/enlisted men relations; good chance of promotion in military; stay in army after war; adjustment to army life; combat experience; worried about family/friends back home; length of war with Germany/Japan; effort in beating Germany/Japan; allies victory/defeat; another war in next 25 years; rather fight Germany or Japan in war; cooperation in company; pride in military occupation; pride in regiment; attention to problems in US during war; getting a job after the war; dangerous foreign military forces; officer/enlisted men relations; problems in company; military equipment; satisfaction of army; rules and regulations; punishment from company; army record; military training; respondent's physical condition; understanding of why US is in war; personal stake in war; military food; medical attention in military; mail services; worth fighting in war; US better/worse place after war; US/foreign countries relations after war.
Flitsch, Mareile: Der Kang. Eine Studie zur materiellen Alltagskultur bäuerlicher Gehöfte in der Manjurei
Creators: name: Wu, Xiujie
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2022

description: ASIEN: The German Journal on Contemporary Asia, Nr. 95 (2005): ASIEN (April)
Expression, Purification, and Mechanistic Studies of Bovine Mitochondrial Translational Initiation Factor 2
Creators: name: Spremulli, Linda L.
name: Ma, Jianhong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: A complete cDNA clone encoding bovine mitochondrial translational initiation factor 2 (IF-2mt) has been obtained. The regions of the cDNA corresponding to mature IF-2mt and several of its functional domains have been expressed in Escherichia coli as histidine-tagged proteins. The precursor (approximately 90 kDa) and mature (approximately 85 kDa) forms of IF-2mt are toxic to E. coli and can only be expressed at low levels. Shorter forms of this factor (approximately 80 and approximately 72 kDa) are also found during the expression of mature IF-2mt. The various forms of IF-2mt can be separated by high performance liquid chromatography. All of these forms are active in promoting the GTP-dependent binding of formyl-Met-tRNA to the small subunit of either E. coli or bovine mitochondrial ribosomes. IF-2mt can bind to mitochondrial ribosomes in the absence of GTP, initiator tRNA, or messenger RNA. The presence of GTP stimulates IF-2mt binding to ribosomes about 3-fold. IF-2mt interacts only weakly with GTP or with the initiator tRNA in the absence of ribosomes. Molecular dissection of IF-2mt shows that a long deletion (approximately 150 amino acid residues) from the NH2-terminal region does not affect its activity in vitro. The COOH domain of IF-2mt (amino acid residues 332-727) can bind to ribosomes even though it does not promote initiator-tRNA binding.
(2023) Mary Ann Dufton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Functional Analysis of Aquaporin-1 Deficient Red Cells: THE COLTON-NULL PHENOTYPE
Creators: name: Mohandas, Narla
name: Mori, Susumu
name: Zeidel, Mark L.
name: Preston, Gregory M.
name: Van Zijl, Peter C.M.
name: Mathai, John C.
name: Agre, Peter
name: Collins, Myra
name: Smith, Barbara L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The aquaporin-1 (AQP1) water transport protein contains a polymorphism corresponding to the Colton red blood cell antigens. To define the fraction of membrane water permeability mediated by AQP1, red cells were obtained from human kindreds with the rare Colton-null phenotype. Homozygosity or heterozygosity for deletion of exon I in AQP1 correlated with total or partial deficiency of AQP1 protein. Homozygote red cell morphology appeared normal, but clinical laboratory studies revealed slightly reduced red cell life span in vivo; deformability studies revealed a slight reduction in membrane surface area. Diffusional water permeability (Pd) was measured under isotonic conditions by pulsed field gradient NMR. Osmotic water permeability (Pf) was measured by change in light scattering after rapid exposure of red cells to increased extracellular osmolality. AQP1 contributes approximately 64% (Pd = 1.5 x 10(-3) cm/s) of the total diffusional water permeability pathway, and lipid permeation apparently comprises approximately 23%. In contrast, AQP1 contributes > 85% (Pf = 19 x 10(-3) cm/s) of the total osmotic water permeability pathway, and lipid permeation apparently comprises only approximately 10%. The ratio of AQP1-mediated Pf to Pd predicts the length of the aqueous pore to be 36 A.
Figure S1 from Sills and gas generation in the Siberian Traps.
Creators: name: Svensen, Henrik H.
name: Frolov, Sergei
name: Akhmanov, Grigorii G.
name: Polozov, Alexander G.
name: Jerram, Dougal A.
name: Shiganova, Olga
name: Melnikov, Nikolay
name: Iyer, Karthik
name: Planke, Sverre
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Additional logs from the Tunguska Basin in East Siberia.
Histone H1 Enhances the DNA Binding Activity of the Transcription Factor EmBP-1
Creators: name: Schultz, Thomas F.
name: Spiker, Steven
name: Quatrano, Ralph S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Previous work indicated that nuclear extracts isolated from embryogenic rice suspension cells treated with the phytohormone abscisic acid (ABA) have enhanced binding activity to an ABA response element (Em1a) in the promoter of the Em gene from wheat. We identified an activity in wheat and maize nuclear extracts that enhances binding of the recombinant transcription factor EmBP-1 to Em1a by 80-fold. Fractionation of nuclear extracts led us to identify histone H1 and HMGb (but not HMGc or -d) as two factors that can enhance the ability of EmBP-1 to bind to Em1a and account for at least a part of this activity of nuclear extracts. Our results, which indicate for the first time that histone H1 possesses this type of activity, lend further support to the model that positively charged proteins can drastically affect the DNA binding activity of species transcription factors. Furthermore, our study points to these chromosomal proteins as potential targets of an ABA-mediated modification (e.g. acetylation) that could affect the regulation of Em gene expression.