Federated Learning Enables Big Data for Rare Cancer Boundary Detection
Creators: name: Pati, Sarthak
name: Baid, Ujjwal
name: Edwards, Brandon
name: Sheller, Micah
name: Wang, Shih-Han
name: Reina, G Anthony
name: Foley, Patrick
name: Gruzdev, Alexey
name: Karkada, Deepthi
name: Davatzikos, Christos
name: Sako, Chiharu
name: Ghodasara, Satyam
name: Bilello, Michel
name: Mohan, Suyash
name: Vollmuth, Philipp
name: Brugnara, Gianluca
name: Preetha, Chandrakanth J
name: Sahm, Felix
name: Maier-Hein, Klaus
name: Zenk, Maximilian
name: Bendszus, Martin
name: Wick, Wolfgang
name: Calabrese, Evan
name: Rudie, Jeffrey
name: Villanueva-Meyer, Javier
name: Cha, Soonmee
name: Ingalhalikar, Madhura
name: Jadhav, Manali
name: Pandey, Umang
name: Saini, Jitender
name: Garrett, John
name: Larson, Matthew
name: Jeraj, Robert
name: Currie, Stuart
name: Frood, Russell
name: Fatania, Kavi
name: Huang, Raymond Y
name: Chang, Ken
name: Balana, Carmen
name: Capellades, Jaume
name: Puig, Josep
name: Trenkler, Johannes
name: Pichler, Josef
name: Necker, Georg
name: Haunschmidt, Andreas
name: Meckel, Stephan
name: Shukla, Gaurav
name: Liem, Spencer
name: Alexander, Gregory S
name: Lombardo, Joseph
name: Palmer, Joshua D
name: Flanders, Adam E
name: Dicker, Adam P
name: Sair, Haris I
name: Jones, Craig K
name: Venkataraman, Archana
name: Jiang, Meirui
name: So, Tiffany Y
name: Chen, Cheng
name: Heng, Pheng Ann
name: Dou, Qi
name: Kozubek, Michal
name: Lux, Filip
name: Michálek, Jan
name: Matula, Petr
name: Keřkovský, Miloš
name: Kopřivová, Tereza
name: Dostál, Marek
name: Vybíhal, Václav
name: Vogelbaum, Michael A
name: Mitchell, J Ross
name: Farinhas, Joaquim
name: Maldjian, Joseph A
name: Yogananda, Chandan Ganesh Bangalore
name: Pinho, Marco C
name: Reddy, Divya
name: Holcomb, James
name: Wagner, Benjamin C
name: Ellingson, Benjamin M
name: Cloughesy, Timothy F
name: Raymond, Catalina
name: Oughourlian, Talia
name: Hagiwara, Akifumi
name: Wang, Chencai
name: To, Minh-Son
name: Bhardwaj, Sargam
name: Chong, Chee
name: Agzarian, Marc
name: Falcão, Alexandre Xavier
name: Martins, Samuel B
name: Teixeira, Bernardo C A
name: Sprenger, Flávia
name: Menotti, David
name: Lucio, Diego R
name: LaMontagne, Pamela
name: Marcus, Daniel
name: Wiestler, Benedikt
name: Kofler, Florian
name: Ezhov, Ivan
name: Metz, Marie
name: Jain, Rajan
name: Lee, Matthew
name: Lui, Yvonne W
name: McKinley, Richard
name: Slotboom, Johannes
name: Radojewski, Piotr
name: Meier, Raphael
name: Wiest, Roland
name: Murcia, Derrick
name: Fu, Eric
name: Haas, Rourke
name: Thompson, John
name: Ormond, David Ryan
name: Badve, Chaitra
name: Sloan, Andrew E
name: Vadmal, Vachan
name: Waite, Kristin
name: Colen, Rivka R
name: Pei, Linmin
name: Ak, Murat
name: Srinivasan, Ashok
name: Bapuraj, J Rajiv
name: Rao, Arvind
name: Wang, Nicholas
name: Yoshiaki, Ota
name: Moritani, Toshio
name: Turk, Sevcan
name: Lee, Joonsang
name: Prabhudesai, Snehal
name: Morón, Fanny
name: Mandel, Jacob
name: Kamnitsas, Konstantinos
name: Glocker, Ben
name: Dixon, Luke V M
name: Williams, Matthew
name: Zampakis, Peter
name: Panagiotopoulos, Vasileios
name: Tsiganos, Panagiotis
name: Alexiou, Sotiris
name: Haliassos, Ilias
name: Zacharaki, Evangelia I
name: Moustakas, Konstantinos
name: Kalogeropoulou, Christina
name: Kardamakis, Dimitrios M
name: Choi, Yoon Seong
name: Lee, Seung-Koo
name: Chang, Jong Hee
name: Ahn, Sung Soo
name: Luo, Bing
name: Poisson, Laila
name: Wen, Ning
name: Tiwari, Pallavi
name: Verma, Ruchika
name: Bareja, Rohan
name: Yadav, Ipsa
name: Chen, Jonathan
name: Kumar, Neeraj
name: Smits, Marion
name: van der Voort, Sebastian R
name: Alafandi, Ahmed
name: Incekara, Fatih
name: Wijnenga, Maarten MJ
name: Kapsas, Georgios
name: Gahrmann, Renske
name: Schouten, Joost W
name: Dubbink, Hendrikus J
name: Vincent, Arnaud JPE
name: Bent, Martin J van den
name: French, Pim J
name: Klein, Stefan
name: Yuan, Yading
name: Sharma, Sonam
name: Tseng, Tzu-Chi
name: Adabi, Saba
name: Niclou, Simone P
name: Keunen, Olivier
name: Hau, Ann-Christin
name: Vallières, Martin
name: Fortin, David
name: Lepage, Martin
name: Landman, Bennett
name: Ramadass, Karthik
name: Xu, Kaiwen
name: Chotai, Silky
name: Chambless, Lola B
name: Mistry, Akshitkumar
name: Thompson, Reid C
name: Gusev, Yuriy
name: Bhuvaneshwar, Krithika
name: Sayah, Anousheh
name: Bencheqroun, Camelia
name: Belouali, Anas
name: Madhavan, Subha
name: Booth, Thomas C
name: Chelliah, Alysha
name: Modat, Marc
name: Shuaib, Haris
name: Dragos, Carmen
name: Abayazeed, Aly
name: Kolodziej, Kenneth
name: Hill, Michael
name: Abbassy, Ahmed
name: Gamal, Shady
name: Mekhaimar, Mahmoud
name: Qayati, Mohamed
name: Reyes, Mauricio
name: Park, Ji Eun
name: Yun, Jihye
name: Kim, Ho Sung
name: Mahajan, Abhishek
name: Muzi, Mark
name: Benson, Sean
name: Beets-Tan, Regina G H
name: Teuwen, Jonas
name: Herrera-Trujillo, Alejandro
name: Trujillo, Maria
name: Escobar, William
name: Abello, Ana
name: Bernal, Jose
name: Gómez, Jhon
name: Choi, Joseph
name: Baek, Stephen
name: Kim, Yusung
name: Ismael, Heba
name: Allen, Bryan
name: Buatti, John M
name: Kotrotsou, Aikaterini
name: Li, Hongwei
name: Weiss, Tobias
name: Weller, Michael
name: Bink, Andrea
name: Pouymayou, Bertrand
name: Shaykh, Hassan F
name: Saltz, Joel
name: Prasanna, Prateek
name: Shrestha, Sampurna
name: Mani, Kartik M
name: Payne, David
name: Kurc, Tahsin
name: Pelaez, Enrique
name: Franco-Maldonado, Heydy
name: Loayza, Francis
name: Quevedo, Sebastian
name: Guevara, Pamela
name: Torche, Esteban
name: Mendoza, Cristobal
name: Vera, Franco
name: Ríos, Elvis
name: López, Eduardo
name: Velastin, Sergio A
name: Ogbole, Godwin
name: Oyekunle, Dotun
name: Odafe-Oyibotha, Olubunmi
name: Osobu, Babatunde
name: Shu'aibu, Mustapha
name: Dorcas, Adeleye
name: Soneye, Mayowa
name: Dako, Farouk
name: Simpson, Amber L
name: Hamghalam, Mohammad
name: Peoples, Jacob J
name: Hu, Ricky
name: Tran, Anh
name: Cutler, Danielle
name: Moraes, Fabio Y
name: Boss, Michael A
name: Gimpel, James
name: Veettil, Deepak Kattil
name: Schmidt, Kendall
name: Bialecki, Brian
name: Marella, Sailaja
name: Price, Cynthia
name: Cimino, Lisa
name: Apgar, Charles
name: Shah, Prashant
name: Menze, Bjoern
name: Barnholtz-Sloan, Jill S
name: Martin, Jason
name: Bakas, Spyridon
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally sharing ample, and importantly diverse, data from multiple sites. However, such centralization is challenging to scale (or even not feasible) due to various limitations. Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here we present findings from the largest FL study to-date, involving data from 71 healthcare institutions across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, utilizing the largest dataset of such patients ever used in the literature (25,256 MRI scans from 6,314 patients). We demonstrate a 33% improvement over a publicly trained model to delineate the surgically targetable tumor, and 23% improvement over the tumor's entire extent. We anticipate our study to: 1) enable more studies in healthcare informed by large and diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further quantitative analyses for glioblastoma via performance optimization of our consensus model for eventual public release, and 3) demonstrate the effectiveness of FL at such scale and task complexity as a paradigm shift for multi-site collaborations, alleviating the need for data sharing.
description: federated learning, deep learning, convolutional neural network, segmentation, brain tumor, glioma, glioblastoma, FeTS, BraTS