title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð¿ÑÐµÐ´ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¸ÐºÐ° Ð½Ð¸ÐºÐ¾ÑÐ¸Ð½Ð°Ð¼Ð¸Ð´Ð°Ð´ÐµÐ½Ð¸Ð½Ð´Ð¸Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð° Ð½Ð° Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¾ÑÐ³Ð°Ð½Ð¾Ð²-Ð¼Ð¸ÑÐµÐ½ÐµÐ¹ ÐºÑÑÑ Ñ Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½-Ð¸Ð½Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ ÐºÐ°ÑÐ´Ð¸Ð¾Ð¼Ð¸Ð¾Ð¿Ð°ÑÐ¸ÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Influence of the precursor nicotinamide adenine dinucleotide on the morphological features of target organs in rats with doxorubicin-induced cardiomyopathy
Creators: name: ÐÐ¾Ð½ÑÐ°ÑÐ¾Ð²Ð°, ÐÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
ÐÐ½ÑÐ¸Ð±Ð¸Ð¾ÑÐ¸ÐºÐ¸
Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½-Ð¸Ð½Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ ÐºÐ°ÑÐ´Ð¸Ð¾Ð¼Ð¸Ð¾Ð¿Ð°ÑÐ¸Ñ
Ð´Ð¾ÐºÑÐ¾ÑÑÐ±Ð¸ÑÐ¸Ð½
Ð½Ð¸ÐºÐ¾ÑÐ¸Ð½Ð°Ð¼Ð¸Ð´ ÑÐ¸Ð±Ð¾Ð·Ð¸Ð´
doxorubicin-induced cardiomyopathy
doxorubicin
nicotinamide riboside

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description: The subject of the graduate qualification work is Â«Influence of the precursor nicotinamide adenine dinucleotide on the morphological features of target organs in rats with doxorubicin-induced cardiomyopathyÂ». The given work is devoted to studying the effect of the precursor nicotinamide adenine dinucleotide on the morphological features of target organs in rats with doxorubicin-induced cardiomyopathy. The object of study in this work is the target organs of rats with doxorubicin-induced cardiomyopathy. The subject of the study is the morphological changes that occur in them during the modeling of chronic doxorubicin-induced cardiomyopathy. The aim of the study was to evaluate (according to certain criteria) the effect of the precursor nicotinamide adenine dinucleotide on the morphological features of target organs in rats with doxorubicin-induced cardiomyopathy. In this work, to solve the tasks, we used such methods as histological processing of the material with the cutting of organs of laboratory animals necessary for the experiment, the preparation of histological sections and their staining, namely, hematoxylin-eosin staining and Mallory staining. The method of morphometry, necessary for the analysis of histological data, was also used. At the first stage of this work, a comparative study of morphological changes in the tissues of the left ventricle of the myocardium of rats, caused by the introduction of various cumulative doses of doxorubicin in the range of 5-15 mg/kg, was carried out, during which the following characteristic changes were revealed: necrosis and apoptosis of cardiomyocytes with diapedetic hemorrhages in them, lymphoplasmacytic infiltration, the presence of cardiomyocytes with vacuolated cytoplasm, as well as the presence of collagen fibrosis. The severity of the effects on myocardial tissues depended on the cumulative dose of the drug. With an increase in the dose of doxorubicin in the range of 5-15 mg/kg, the severity increased. In addition, a cumulative dose of doxorubicin was determined equal to 10 mg/kg, which can be considered as the optimal cumulative dose that provides systemic toxicity and morphological changes in myocardial tissues with sufficient animal survival to model chronic doxorubicin-induced cardiomyopathy. At the next stage of the work, the cardioprotective effects of the precursor of nicotinamide adenine dinucleotide, nicotinamide riboside, were confirmed, and the infusion regimes of this drug were determined, which provide a significantly significant decrease in the area of ââcollagen fibrosis in different areas of the tissue of the left ventricle of the rat heart in a model of chronic doxorubicin cardiomyopathy. The results of the study allow us to expand the existing understanding of the morphological features of doxorubicin-induced myocardial damage, and can also be used in the development of approaches for the prevention and treatment of doxorubicin-induced cardiomyopathy based on nicotinamide adenine dinucleotide precursors.