cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Using bodily postures in the treatment of anorexia nervosa: effects of power posing on interoception and affective states
Creators: name: Weineck, Felicitas
name: Hauke, Gernot
name: Lindemann, Hanna
name: Lachenmeir, Karin
name: Schnebel, Andreas
name: Karačić, Matislava
name: Meule, Adrian
name: Voderholzer, Ulrich
name: Pollatos, Olga
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Power posing
subject: DDC 150 / Psychology
subject: Cognitive psychology
subject: Interoception
subject: Body image
subject: Anorexia nervosa
subject: Interozeption
subject: Embodiment

description: Objective Power posing involves the adoption of an expansive bodily posture. This study examined whether power posing could benefit individuals with anorexia nervosa (AN) and women with normal weight in regards to interoceptive ability and affective states. Method Participants included 50 inpatients and outpatients with AN as well as 51 normal-weight women. Interoceptive accuracy (IAcc), measured by the heartbeat tracking task and interoceptive sensibility (IS), measured by confidence ratings, were assessed at baseline, after a single power posing session and after 1 week of daily training. Also, the short-term effects of power posing on subjective feelings of dominance, pleasantness, and arousal were investigated. Results Both groups increased in their IAcc after one power posing session. Also, there was a significant main effect of time on feelings of dominance and pleasantness in the short-term. Women with AN displayed lower levels of IS, dominance, and pleasantness as well as higher levels of arousal than women without AN. Discussion These findings suggest that power posing has the potential to increase IAcc, subjective feelings of power and pleasant affect in the short-term. Further research should investigate which mechanisms foster the effectiveness of this intervention to tailor it to the needs of women with AN. Highlights Feelings of powerlessness are prominent in AN but few concrete interventions exist that directly address this concern. Power posing has the potential to increase interoceptive accuracy, subjective feelings of power and pleasant affect in the short-term. Women with AN display lower levels of interoceptive sensibility than women without AN.
Entitäten in DSpace : Aktivierung, Fallstricke und Möglichkeiten
Creators: name: Paulsen, Yannick
Publisher: name: Zenodo
Year: 2024
Subjects: DSpace
Repository
Dokumentenserver
Entities
Entitätenmodell

description: Abstract von der Konferenz:

Die konfigurierbaren Entitäten sind ein neu hinzugekommenes Feature von DSpace 7, welches, sollte es umfassend implementiert werden, für die gesamte Struktur der jeweiligen DSpace-Instanz sowie vieler Teilbereiche wie Suchkonfigurationen, Einreichungsworkflows oder der Verwendung von Metadaten von Bedeutung ist. Da das Feature optional ist und mit vielen nötigen Überlegungen einhergeht, haben viele Repositorien das Thema erstmal zurückgestellt.

[...] Im zweiten Teil wird die konkrete technische Umsetzung besprochen, indem die einzelnen Schritte und Konfigurationsdateien durchgegangen werden. Dies wird zum Schluss in einer Live-Demo beispielhaft vorgeführt.

Dieser Workshop ist interessant für Institutionen, die noch am Umstieg auf DSpace 7 arbeiten, als auch für Institutionen, die bereits umgestiegen sind, jedoch die konfigurierbaren Entitäten noch nicht nutzen.
Claimed advantages and disadvantages of (dedicated) model transformation languages : a systematic literature review
Creators: name: Götz, Stefan
name: Tichy, Matthias
name: Groner, Raffaela
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Model Transformation Language
subject: Model transformation
subject: MDSE
subject: Advantages
subject: Disadvantages
subject: DDC 004 / Data processing & computer science
subject: DDC 620 / Engineering & allied operations
subject: Digital subscriber lines
subject: DSL
subject: Modelltransformation

description: There exists a plethora of claims about the advantages and disadvantages of model transformation languages compared to general-purpose programming languages. With this work, we aim to create an overview over these claims in the literature and systematize evidence thereof. For this purpose, we conducted a systematic literature review by following a systematic process for searching and selecting relevant publications and extracting data. We selected a total of 58 publications, categorized claims about model transformation languages into 14 separate groups and conceived a representation to track claims and evidence through the literature. From our results, we conclude that: (i) the current literature claims many advantages of model transformation languages but also points towards certain deficits and (ii) there is insufficient evidence for claimed advantages and disadvantages and (iii) there is a lack of research interest into the verification of claims.
High proton‐conductivity in covalently linked polyoxometalate‐organoboronic acid‐polymers
Creators: name: Li, Shujun
name: Zhao, Yue
name: Knoll, Sebastian
name: Liu, Rongji
name: Li, Gang
name: Peng, Qingpo
name: Qiu, Pengtao
name: He, Danfeng
name: Streb, Carsten
name: Chen, Xuenian
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: boronic acid
subject: organo-functionalization
subject: DDC 540 / Chemistry & allied sciences
subject: Polyoxometalates
subject: Self-assembly (Chemistry)
subject: Supramolecular chemistry
subject: Supramolekulare Chemie

description: Polyoxometalate polymers with high proton conductivity are accessed for the first time by controlled covalent polymerization of Wells–Dawson-type niobotungstate and organoboronic acid monomers. The resulting polymer features a purely inorganic backbone, organic sidechains, and acts as a solid-state proton conductor. The controlled bottom‐up design of polymers with metal oxide backbones is a grand challenge in materials design, as it could give unique control over the resulting chemical properties. Herein, we report a 1D‐organo‐functionalized polyoxometalate polymer featuring a purely inorganic backbone. The polymer is self‐assembled from two types of monomers, inorganic Wells–Dawson‐type polyoxometalates, and aromatic organo‐boronates. Their covalent linkage results in 1D polymer strands, which combine an inorganic oxide backbone (based on B−O and Nb−O linkages) with functional organic side‐chains. The polymer shows high bulk proton conductivity of up to 1.59×10−1 S cm−1 at 90 °C and 98 % relative humidity. This synthetic approach could lead to a new class of organic–inorganic polymers where function can be designed by controlled tuning of the monomer units.
The lineaments of Newland iron furnace, 1747-1903; an historical investigation.
Creators: name: Marshall, J D
name: Helme, J
name: Wignall, J
name: Braithwaite, J C C
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 195-214
description: Industrial Archaeology Sub-Committee (CWAAS) led survey work at one of three major charcoal iron furnaces in the area. An appendix `Stocks, production and blast periods at Newland' by J Helme (213) concludes.
Troutbeck Chapel of Ease from its foundation to 1800.
Creators: name: Parsons, M A
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 139-160
description: Mostly historical account of independent-minded communities chapel from its probable late-fifteenth-century beginnings to the eighteenth century.
A seventeenth century treasure trove in Furness.
Creators: name: White, Andrew
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 115-121
description: Duchy of Lancaster papers in the Public Record Office (Chancery Lane, London) refer to a coin hoard found near Ulverston in 1621-22. Contained in a lead pot were fifty-two gold coins and ninety-eight or ninety-nine silver coins of uncertain origin. The author speculates that they were either British, dating to between the fourteenth and fifteenth centuries, or else foreign.
Neuropathological interpretation of stimulated Raman histology images of brain and spine tumors: part B
Creators: name: Straehle, Jakob
name: Erny, Daniel
name: Neidert, Nicolas
name: Heiland, Dieter Henrik
name: El Rahal, Amir
name: Sacalean, Vlad
name: Steybe, David
name: Schmelzeisen, Rainer
name: Vlachos, Andreas
name: Mizaikoff, Boris
name: Reinacher, Peter Christoph
name: Coenen, Volker Arnd
name: Prinz, Marco
name: Beck, Jürgen
name: Schnell, Oliver
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Stimulated Raman histology (SRH)
subject: Neuropathology
subject: Diagnostic accuracy
subject: Neurosurgery
subject: NIO
subject: H&E-stained frozen section
subject: CORTICOSPINAL TRACT
subject: LABEL-FREE
subject: SURGERY
subject: SYSTEM
subject: AGREEMENT
subject: RESECTION
subject: ACCURACY
subject: GLIOMA
subject: DDC 610 / Medicine & health

description: Abstract Intraoperative histopathological examinations are routinely performed to provide neurosurgeons with information about the entity of tumor tissue. Here, we quantified the neuropathological interpretability of stimulated Raman histology (SRH) acquired using a Raman laser imaging system in a routine clinical setting without any specialized training or prior experience. Stimulated Raman scattering microscopy was performed on 117 samples of pathological tissue from 73 cases of brain and spine tumor surgeries. A board-certified neuropathologist — novice in the interpretation of SRH — assessed image quality by scoring subjective tumor infiltration and stated a diagnosis based on the SRH images. The diagnostic accuracy was determined by comparison to frozen hematoxylin–eosin (H&E)-stained sections and the ground truth defined as the definitive neuropathological diagnosis. The overall SRH imaging quality was rated high with the detection of tumor cells classified as inconclusive in only 4.2% of all images. The accuracy of neuropathological diagnosis based on SRH images was 87.7% and was non-inferior to the current standard of fast frozen H&E-stained sections (87.3 vs. 88.9%, p = 0.783). We found a substantial diagnostic correlation between SRH-based neuropathological diagnosis and H&E-stained frozen sections (κ = 0.8). The interpretability of intraoperative SRH imaging was demonstrated to be equivalent to the current standard method of H&E-stained frozen sections. Further research using this label-free innovative alternative vs. conventional staining is required to determine to which extent SRH-based intraoperative decision-making can be streamlined in order to facilitate the advancement of surgical neurooncology.
Marital fertility at Penrith, 1557-1812 - evidence for a malnourished community?
Creators: name: Scott, Susan
name: Duncan, C J J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 105-114
description: Evidence for the correlation between nutrition and fertility.
Systematic review and Meta-analysis file
Creators: name: Winata, I Gde Sastra
name: Simatupang, Januar
name: Polim, Arie A
name: Togar, Yakob
name: Tondang, Advenny Elisabeth
Publisher: name: figshare
Year: 2022
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: RevMan analysis, Data spreadsheets, Supplementary materials, PRISMA check list.
Genome‐wide DNA methylation analysis along the progression of gastric marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue (MALT) type
Creators: name: Dugge, Rucha
name: Wagener, Rabea
name: Mӧller, Peter
name: Barth, Thomas F. E.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: MALT lymphoma
subject: marginal zone lymphoma
subject: extra‐nodal lymphoma
subject: lymphoma progression
subject: DDC 610 / Medicine & health
subject: Lymphoma, B-Cell, Marginal zone
subject: DNA methylation
subject: B-Zell-Lymphom
subject: DNS-Methyltransferase

description: Summary Extra‐nodal marginal zone B‐cell lymphoma (MZBL) of mucosa‐associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small‐cell morphology (SC‐MZBL) and often arises in the background of Helicobacter pylori‐induced gastritis. In some cases, a clonal malignant progression to large‐cell morphology (LC‐MZBL) is observed. Here, we studied the DNA methylation profile of 30 gastric MZBLs along their progression. Genome‐wide DNA methylation profiling, identified 7698 significantly differentially methylated loci during gastric MZBL progression (σ/σmax ≥0·4, q ≤ 0·001). LC‐MZBL showed hypermethylation in comparison to SC‐MZBL with an enrichment of regions involved in transcriptional regulation. In conclusion, our present data show that the morphological distinction between SC‐ and LC‐MZBL is reflected by characteristic DNA methylation profiles.
Additional file 1 of Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway
Creators: name: Xu, Jiaojiao
name: Ma, Luyao
name: Wang, Danqing
name: Yang, Jianhong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 1.
EANM position paper on the role of radiobiology in nuclear medicine
Creators: name: Aerts, An
name: Eberlein, Uta
name: Holm, Sören
name: Hustinx, Roland
name: Konijnenberg, Mark
name: Strigari, Lidia
name: Van Leeuwen, Fijs W.B.
name: Glatting, Gerhard
name: Lassmann, Michael
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Radiobiology
subject: Dosimetry
subject: Biodosimetry
subject: Biomarkers
subject: Radionuclide therapy
subject: DOUBLE-STRAND BREAKS
subject: CIRCULATING TRANSCRIPT ANALYSIS
subject: RECEPTOR RADIONUCLIDE THERAPY
subject: PERIPHERAL-BLOOD LYMPHOCYTES
subject: DNA-DAMAGE
subject: RADIOPEPTIDE LU-177-OCTREOTATE
subject: LU-177-DOTATATE TREATMENT
subject: MOLECULAR RADIOTHERAPY
subject: NEUROENDOCRINE TUMORS
subject: INTERNAL DOSIMETRY
subject: DDC 610 / Medicine & health

description: Executive Summary With an increasing variety of radiopharmaceuticals for diagnostic or therapeutic nuclear medicine as valuable diagnostic or treatment option, radiobiology plays an important role in supporting optimizations. This comprises particularly safety and efficacy of radionuclide therapies, specifically tailored to each patient. As absorbed dose rates and absorbed dose distributions in space and time are very different between external irradiation and systemic radionuclide exposure, distinct radiation-induced biological responses are expected in nuclear medicine, which need to be explored. This calls for a dedicated nuclear medicine radiobiology. Radiobiology findings and absorbed dose measurements will enable an improved estimation and prediction of efficacy and adverse effects. Moreover, a better understanding on the fundamental biological mechanisms underlying tumor and normal tissue responses will help to identify predictive and prognostic biomarkers as well as biomarkers for treatment follow-up. In addition, radiobiology can form the basis for the development of radiosensitizing strategies and radioprotectant agents. Thus, EANM believes that, beyond in vitro and preclinical evaluations, radiobiology will bring important added value to clinical studies and to clinical teams. Therefore, EANM strongly supports active collaboration between radiochemists, radiopharmacists, radiobiologists, medical physicists, and physicians to foster research toward precision nuclear medicine.
Assessing the attitude towards artificial intelligence : introduction of a short measure in German, Chinese, and English language
Creators: name: Sindermann, Cornelia
name: Sha, Peng
name: Zhou, Min
name: Wernicke, Jennifer
name: Schmitt, Helena S.
name: Li, Mei
name: Sariskaya, Rayna
name: Stavrou, Maria
name: Becker, Benjamin
name: Montag, Christian
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: ATAI
subject: German
subject: ATAI scale
subject: Attitude Towards Artificial Intelligence
subject: DDC 620 / Engineering & allied operations
subject: Artificial intelligence
subject: Chinese
subject: English language
subject: Künstliche Intelligenz
subject: Englisch

description: In the context of (digital) human–machine interaction, people are increasingly dealing with artificial intelligence in everyday life. Through this, we observe humans who embrace technological advances with a positive attitude. Others, however, are particularly sceptical and claim to foresee substantial problems arising from such uses of technology. The aim of the present study was to introduce a short measure to assess the Attitude Towards Artificial Intelligence (ATAI scale) in the German, Chinese, and English languages. Participants from Germany (N = 461; 345 females), China (N = 413; 145 females), and the UK (N = 84; 65 females) completed the ATAI scale, for which the factorial structure was tested and compared between the samples. Participants from Germany and China were additionally asked about their willingness to interact with/use self-driving cars, Siri, Alexa, the social robot Pepper, and the humanoid robot Erica, which are representatives of popular artificial intelligence products. The results showed that the five-item ATAI scale comprises two negatively associated factors assessing (1) acceptance and (2) fear of artificial intelligence. The factor structure was found to be similar across the German, Chinese, and UK samples. Additionally, the ATAI scale was validated, as the items on the willingness to use specific artificial intelligence products were positively associated with the ATAI Acceptance scale and negatively with the ATAI Fear scale, in both the German and Chinese samples. In conclusion we introduce a short, reliable, and valid measure on the attitude towards artificial intelligence in German, Chinese, and English language.
Tnfaip2/exoc3‐driven lipid metabolism is essential for stem cell differentiation and organ homeostasis
Creators: name: Deb, Sarmistha
name: Felix, Daniel A
name: Koch, Philipp
name: Deb, Maharshi Krishna
name: Szafranski, Karol
name: Buder, Katrin
name: Sannai, Mara
name: Groth, Marco
name: Kirkpatrick, Joanna
name: Pietsch, Stefan
name: Gollowitzer, André
name: Groß, Alexander
name: Riemenschneider, Philip
name: Koeberle, Andreas
name: González‐Estévez, Cristina
name: Rudolph, Karl Lenhard
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Exoc3
subject: organ homeostasis
subject: stem cell differentiation
subject: Tnfaip2
subject: DDC 610 / Medicine & health
subject: Lipid metabolism
subject: Cell differentiation
subject: Pluripotent stem cells
subject: Homeostasis
subject: Lipidstoffwechsel
subject: Homöostase
subject: Zelldifferenzierung
subject: Induzierte pluripotente Stammzelle

description: Lipid metabolism influences stem cell maintenance and differentiation but genetic factors that control these processes remain to be delineated. Here, we identify Tnfaip2 as an inhibitor of reprogramming of mouse fibroblasts into induced pluripotent stem cells. Tnfaip2 knockout impairs differentiation of embryonic stem cells (ESCs), and knockdown of the planarian para-ortholog, Smed-exoc3, abrogates in vivo tissue homeostasis and regeneration—processes that are driven by somatic stem cells. When stimulated to differentiate, Tnfaip2-deficient ESCs fail to induce synthesis of cellular triacylglycerol (TAG) and lipid droplets (LD) coinciding with reduced expression of vimentin (Vim)—a known inducer of LD formation. Smed-exoc3 depletion also causes a strong reduction of TAGs in planarians. The study shows that Tnfaip2 acts epistatically with and upstream of Vim in impairing cellular reprogramming. Supplementing palmitic acid (PA) and palmitoyl-L-carnitine (the mobilized form of PA) restores the differentiation capacity of Tnfaip2-deficient ESCs and organ maintenance in Smed-exoc3-depleted planarians. Together, these results identify a novel role of Tnfaip2 and exoc3 in controlling lipid metabolism, which is essential for ESC differentiation and planarian organ maintenance.
Additional file 1 of Media portrayal of ethical and social issues in brain organoid research
Creators: name: Presley, Abigail
name: Samsa, Leigh Ann
name: Dubljević, Veljko
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. List of Media Sources.
Basal activity of PINK1 and PRKN in cell models and rodent brain
Creators: name: Watzlawik, Jens O.
name: Fiesel, Fabienne C.
name: Fiorino, Gabriella
name: Bustillos, Bernardo A.
name: Baninameh, Zahra
name: Markham, Briana N.
name: Hou, Xu
name: Hayes, Caleb S.
name: Bredenberg, Jenny M.
name: Kurchaba, Nicholas W.
name: Fričová, Dominika
name: Siuda, Joanna
name: Wszolek, Zbigniew K.
name: Noda, Sachiko
name: Sato, Shigeto
name: Hattori, Nobutaka
name: Prasad, Asheeta A.
name: Kirik, Deniz
name: Fox, Howard S.
name: Stauch, Kelly L.
name: Goldberg, Matthew S.
name: Springer, Wolfdieter
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective degradation (mitophagy). Complete loss of PINK1 or PRKN function unequivocally leads to early-onset Parkinson disease, but it is debated whether impairments in mitophagy contribute to disease later in life. While the pathway has been extensively studied in cell culture upon acute and massive mitochondrial stress, basal levels of activation under endogenous conditions and especially in vivo in the brain remain undetermined. Using rodent samples, patient-derived cells, and isogenic neurons, we here identified age-dependent, brain region-, and cell type-specific effects and determined expression levels and extent of basal and maximal activation of PINK1 and PRKN. Our work highlights the importance of defining critical risk and therapeutically relevant levels of PINK1-PRKN signaling which will further improve diagnosis and prognosis and will lead to better stratification of patients for future clinical trials.
Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy
Creators: name: Xu, Yinfeng
name: Qian, Chuying
name: Wang, Qian
name: Song, Lijiang
name: He, Zhengfu
name: Liu, Wei
name: Wan, Wei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: LC3 lipidation plays an important role in the regulation of macroautophagy and LC3-associated microautophagy. The E1-like enzyme ATG7 is one of the core components that are directly involved in LC3 lipidation reaction. Here, we provide evidence showing that acetylation of ATG7 tightly controls its enzyme activity to regulate the induction of macroautophagy and LC3-associated microautophagy. Mechanistically, acetylation of ATG7 disrupts its interaction with the E2-like enzyme ATG3, leading to an inhibition of LC3 lipidation in vitro and in vivo. Functionally, in response to various different stimuli, cellular ATG7 undergoes deacetylation to induce macroautophagy and LC3-associated microautophagy, which are necessary for cells to eliminate cytoplasmic DNA and degrade lysosome membrane proteins, respectively. Taken together, these findings reveal that ATG7 acetylation acts as a critical rheostat in controlling LC3 lipidation and related cellular processes. Abbreviations: AMPK: AMP-activated protein kinase; ATG: autophagy-related; cGAMP: cyclic GMP-AMP; CGAS: cyclic GMP-AMP synthase; CREBBP/CBP: CREB binding protein; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; EP300/p300: E1A binding protein p300; IFNB1: interferon beta 1; ISD: interferon stimulatory DNA; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCOLN1/TRPML1: mucolipin TRP cation channel 1; MEF: mouse embryonic fibroblast; MTOR: mechanistic target of rapamycin kinase; NAM: nicotinamide; PE: phosphatidylethanolamine; PTM: post-translational modification; RB1CC1/FIP200: RB1 inducible coiled-coil 1; SIRT: sirtuin; SQSTM1/p62: sequestosome 1; STING1: stimulator of interferon response cGAMP interactor 1; TSA: trichostatin A; ULK1: unc-51 like autophagy activating kinase 1; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild-type.
Clindamycin Use In the Pediatric Population
Creators: name: L, Jenny
Publisher: name: figshare
Year: 2016
Subjects: subject: 111503 Clinical Pharmacy and Pharmacy Practice
subject: FOS: Clinical medicine

description: We determined if clindamycin is being used for appropriate skin and soft tissue infections. We suspected that Staphylococcus aureus susceptibilities to clindamycin have waned over the past few years. Therefore we want to investigated cultures and sensitivities to determine if appropriate antibiotic modification and/or de-escalation was conducted.
TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1
Creators: name: Heo, Hansol
name: Park, Hyungsun
name: Lee, Myung Shin
name: Kim, Jongyoon
name: Kim, Juyeong
name: Jung, Soon-Young
name: Kim, Sun Kyeon
name: Lee, Seongju
name: Chang, Jaerak
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Tripartite motif (TRIM) proteins are a large family of E3 ubiquitin ligases implicated in antiviral defense systems, tumorigenesis, and protein quality control. TRIM proteins contribute to protein quality control by regulating the ubiquitin-proteasome system, endoplasmic reticulum-associated degradation, and macroautophagy/autophagy. However, the detailed mechanisms through which various TRIM proteins regulate downstream events have not yet been fully elucidated. Herein, we identified a novel function of TRIM22 in the regulation of autophagy. TRIM22 promotes autophagosome-lysosome fusion by mediating the association of GABARAP family proteins with PLEKHM1, thereby inducing the autophagic clearance of protein aggregates, independent of its E3 ubiquitin ligase activity. Furthermore, a TRIM22 variant associated with early-onset familial Alzheimer disease interferes with autophagosome-lysosome fusion and autophagic clearance. These findings suggest TRIM22 as a critical autophagic regulator that orchestrates autophagosome-lysosome fusion by scaffolding autophagy-related proteins, thus representing a potential therapeutic target in neurodegenerative diseases. Abbreviations: AD: Alzheimer disease; ADAOO: AD age of onset; AICD: APP intracellular domain; APP: amyloid beta precursor protein; BSA: bovine serum albumin; cDNAs: complementary DNAs; CQ: chloroquine; CTF: carboxyl-terminal fragment; EBSS: Earle’s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GST: glutathione S-transferase; HA: hemagglutinin; HOPS: homotypic fusion and protein sorting; IFN: interferon; IL1A/IL-1α: interleukin 1 alpha; KO: knockout; MTORC1: mechanistic target of rapamycin kinase complex 1; NFKBIA/IκBα: NFKB inhibitor alpha; NFE2L2/NRF2: NFE2 like bZIP transcription factor; PBS: phosphate-buffered saline; PI3K: class I phosphoinositide 3-kinase; PLA: proximity ligation assay; PLEKHM1: pleckstrin homology and RUN domain containing M1; PSEN1: presenilin 1; SEM: standard errors of the means; SNAREs: soluble N-ethylmaleimide-sensitive factor attachment protein receptors; SNCA: synuclein alpha; SNP: single nucleotide polymorphism; TBS: tris-buffered saline; TNF/TNF-α: tumor necrosis factor; TRIM: tripartite motif; ULK1: unc-51 like autophagy activating kinase 1; WT: wild-type
Did mitophagy follow the origin of mitochondria?
Creators: name: Degli Esposti, Mauro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Plant Biology

description: Mitophagy is the process of selective autophagy that removes superfluous and dysfunctional mitochondria. Mitophagy was first characterized in mammalian cells and is now recognized to follow several pathways including basal forms in specific organs. Mitophagy pathways are regulated by multiple, often interconnected factors. The present review aims to streamline this complexity and evaluate common elements that may define the evolutionary origin of mitophagy. Key issues surrounding mitophagy signaling at the mitochondrial surface may fundamentally derive from mitochondrial membrane dynamics. Elements of such membrane dynamics likely originated during the endosymbiosis of the alphaproteobacterial ancestor of our mitochondria but underwent an evolutionary leap forward in basal metazoa that determined the currently known variations in mitophagy signaling. Abbreviations: AGPAT, 1-acylglycerol-3-phosphate O-acyltransferase; ATG, autophagy related; BCL2L13, BCL2 like 13; BNIP3, BCL2 interacting protein 3; BNIP3L, BCL2 interacting protein 3 like; CALCOCO, calcium binding and coiled-coil domain; CL, cardiolipin; ER, endoplasmic reticulum; ERMES, ER-mitochondria encounter structure; FBXL4, F-box and leucine rich repeat protein 4; FUNDC1, FUN14 domain containing 1; GABARAPL1, GABA type A receptor associated protein like 1; HIF, hypoxia inducible factor; IMM, inner mitochondrial membrane; LBPA/BMP, lysobisphosphatidic acid; LIR, LC3-interacting region; LPA, lysophosphatidic acid; MAM, mitochondria-associated membranes; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MCL, monolysocardiolipin; ML, maximum likelihood; NBR1, NBR1 autophagy cargo receptor; OMM, outer mitochondrial membrane; PA, phosphatidic acid; PACS2, phosphofurin acidic cluster sorting protein 2; PC/PLC, phosphatidylcholine; PE, phosphatidylethanolamine; PHB2, prohibitin 2; PINK1, PTEN induced kinase 1; PtdIns, phosphatidylinositol; SAR, Stramenopiles, Apicomplexa and Rhizaria; TAX1BP1, Tax1 binding protein 1; ULK1, unc-51 like autophagy activating kinase 1; VDAC/porin, voltage dependent anion channel.
Emotional Experience during Human-Computer Interaction: A Survey
Creators: name: Tang, Lilu
name: Yuan, Peijun
name: Zhang, Dan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: As human-computer interaction (HCI) technology becomes more and more integrated into our daily life, increasing attention has been drawn towards the interaction experience in addition to HCI efficiency. In the present study, we conducted a survey to explore context-specific emotional experience in HCI. Four hundred participants were recruited to report the frequency of their emotional experiences on 44 fine-grained emotion items in six representative HCI scenarios. Compared with six matched human-human interaction (HHI) scenarios used as control, the HCI scenarios were in general more frequently associated with negative emotions, and less frequently associated with positive emotions, especially when computer served as a tool for communication with other people. Furthermore, the 44 emotional experience items in HCI were summarized as five factors, representing low-arousal focused, positively engaged, emotionally empathetic, high-arousal negative and frustratingly confused. Our study presents a comprehensive overview of context-specific emotional experience in human-computer interactions and provides a framework for emotion evaluation in HCI applications.
Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation
Creators: name: Pierzynowska, Karolina
name: Podlacha, Magdalena
name: Gaffke, Lidia
name: Rintz, Estera
name: Wiśniewska, Karolina
name: Cyske, Zuzanna
name: Węgrzyn, Grzegorz
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Huntington disease (HD) is a neurodegenerative disorder caused by a mutation in the HTT gene. The expansion of CAG triplets leads to the appearance of misfolded HTT (huntingtin) forming aggregates and leading to impairment of neuronal functions. Here we demonstrate that stimulation of macroautophagy/autophagy by genistein (4′,5,7-trihydroxyisoflavone or 5,7-dihydroxy-3-(4-hydroxyphenyl)-4 H-1-benzopyran-4-one) caused a reduction of levels of mutated HTT in brains of HD mice and correction of their behavior as assessed in a battery of cognitive, anxiety and motor tests, even if the compound was administered after symptoms had developed in the animals. Biochemical and immunological parameters were also improved in HD mice. Studies on molecular mechanisms of genistein-mediated stimulation of autophagy in HD cells indicated the involvement of the FOXO3-related pathway. In conclusion, treatment with genistein stimulates the autophagy process in the brains of HD mice, leading to correction of symptoms of HD, suggesting that it might be considered as a potential drug for this disease. Combined with a very recently published report indicating that impaired autophagy may be a major cause of neurodegenerative changes, these results may indicate the way to the development of effective therapeutic approaches for different neurodegenerative diseases by testing compounds (or possibly combinations of compounds) capable of stimulating autophagy and/or unblocking this process. Abbreviations: CNS: central nervous system; EPM: elevated plus-maze; GOT1/ASPAT: glutamic-oxaloacetic transaminase 1, soluble; GPT/ALAT/ALT: glutamic pyruvic transaminase, soluble; HD: Huntington disease; HTT: huntingtin; IL: interleukin; mHTT: mutant huntingtin; NOR: novel object recognition; MWM: Morris water maze; OF: open field; ROS: reactive oxygen species; TNF: tumor necrosis factor
XALQARO EKOLOGIYA HUQUQIDA TRANSCHEGARAVIY SUV RESURSLARIDAN FOYDALANISH VA ULARNI MUHOFAZA QILISHDAGI MUAMMOLAR
Creators: name: Xasanova, Rayhon
name: Sayfullayev, Sirojjon
Publisher: name: Zenodo
Year: 2024

description: Maqolada Markaziy Osiyodagi transchegaraviy daryolarning suv resurslari muammolari va ularni hal etish yo‘llari ko‘rib chiqiladi. Xususan, suv masalalari bo‘yicha mintaqaviy hamkorlikni takomillashtirishga qaratilgan xalqaro konferensiyalarning tavsiyalari tahlil qilingan.
Using consensus group methods such as Delphi and Nominal Group in medical education research*
Creators: name: Humphrey-Murto, Susan
name: Varpio, Lara
name: Gonsalves, Carol
name: Wood, Timothy J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Consensus group methods are widely used in research to identify and measure areas where incomplete evidence exists for decision-making. Despite their widespread use, these methods are often inconsistently used and reported. Using examples from the three most commonly used methods, the Delphi, Nominal Group and RAND/UCLA; this paper and associated Guide aim to describe these methods and to highlight common weaknesses in methodology and reporting. The paper outlines a series of recommendations to assist researchers using consensus group methods in providing a comprehensive description and justification of the steps taken in their study.
A survey of the surviving medieval stained glass in the churches of the Anglican Diocese of Carlisle, together with the few examples of painted glass of the seventeenth and eighteenth centuries, and of the first decade of the nineteenth century.
Creators: name: Smith, Leslie N S
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 87-104
description: Twenty-seven church sites presented alphabetically.
Supplemental Material for Cheng et al. PRSB from Atmospheric rivers and the mass mortality of wild oysters: insight into an extreme future?
Creators: name: Cheng, Brian S.
name: Chang, Andrew L.
name: Deck, Anna
name: Ferner, Matthew C.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: Ecology

description: Population abunance across the species range, map of field sites, metadata for precipitation stations, table of oyster tolerance, and supporting environmental data.
Additional file 1 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 1: Figure S1. Crossing point values of rps17 in the ovaries and the carcass of Ae. aegypti in the same generation of mothers (P1). These data pertain to Fig. 2 in the main text. n = 206, P
Additional file 2 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 2: Figure S2. Crossing point values of rps17 in the ovaries, carcass and eggs of Ae. aegypti. These data pertain to Fig. 4 in the main text. One-way ANOVA P
Additional file 3 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 3: Figure S3. Relative Wolbachia densities (ankyrin repeat domain to rps17) in the ovaries, carcass and eggs of Ae. aegypti in replicate group 2. One-way ANOVA P
The femur too short? 1373 fetuses with short femur during second-trimester screening
Creators: name: Friebe-Hoffmann, Ulrike
name: Dobravsky, Larissa
name: Friedl, Thomas W. P.
name: Janni, Wolfgang
name: Knippel, Alexander J.
name: Siegmann, Hans J.
name: Kozlowski, Peter
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Short femur
subject: Prenatal
subject: SGA
subject: Malformation
subject: DDC 610 / Medicine & health
subject: Aberration
subject: Mangelgeborenes
subject: Missbildung

description: Purpose A short fetal femur in prenatal diagnosis might be an indicator for intrauterine growth retardation (IUGR), a genetically determined small child (SGA) with or without associated fetal malformations and/or an adverse fetal outcome. Methods 1373 singleton pregnancies with a femoral length < 5th percentile detected between 1999 and 2015 during second-trimester screening in a tertiary prenatal diagnostic center were subjected to a descriptive retrospective analysis with regard to fetal characteristics as well as pregnancy outcome. Results 685 (49.9%) fetuses presented an isolated short femur, while 688 (50.1%) showed additional abnormalities. 293 (42.6%) of those were SGA babies without any malformation, while 395 (57.4%) had one or more severe anomaly of the following organ systems: 157 (11.5%) cardiovascular, 101 (7.4%) musculoskeletal, 82 (6.0%) urogenital, 72 (5.2%) cerebrocephalic, 50 (3.6%) gastrointestinal, and 5 (0.4%) thoracic. 75 (5.5%) of the fetuses showed chromosomal aberrations of which Trisomy 13, 18 and 21 were found in 2, 13 and 27 of the cases, respectively. Fetuses with associated malformations had a significantly lower live birth rate than those without (64.2% vs. 98.1%, p < 0.001); in addition, a higher rate of preterm births 36.6% vs. 11.3%, p < 0.001) and SGA babies (51.4% vs. 30.4%, p < 0.001) were observed in the first collective. Conclusion Diagnosis of a short fetal femur should lead to an extended organ screening; in the case of associated abnormalities, additional genetic testing has to be offered, as well as intensified pregnancy monitoring in pregnancies at risk for IUGR and/or preterm birth.
How do adults with autism spectrum disorder participate in the labor market? a German multi-center survey
Creators: name: Maslahati, Tolou
name: Bachmann, Christian J.
name: Höfer, Juliana
name: Küpper, Charlotte
name: Stroth, Sanna
name: Wolff, Nicole
name: Poustka, Luise
name: Roessner, Veit
name: Kamp-Becker, Inge
name: Hoffmann, Falk
name: Roepke, Stefan
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Autism
subject: Autism Spectrum Disorder
subject: Labor Market
subject: Education
subject: Employment
subject: HIGH-FUNCTIONING AUTISM
subject: EMPLOYMENT STATUS
subject: POSTSECONDARY EDUCATION
subject: PSYCHIATRIC-DISORDERS
subject: INDIVIDUALS
subject: OUTCOMES
subject: CHILDREN
subject: YOUTH
subject: EXPERIENCES
subject: CHALLENGES
subject: DDC 150 / Psychology

description: Abstract International studies show disadvantages for adults with autism spectrum disorder (ASD) in the labor market. Data about their participation in the German labor market are scarce. The aim of this study was to examine the integration of adults with ASD in the German labor market in terms of education, employment and type of occupation by means of a cross-sectional-study, using a postal questionnaire. Findings show above average levels of education for adults with ASD compared to the general population of Germany and simultaneously, below average rates of employment and high rates of financial dependency. That indicates a poor integration of adults with ASD in the German labor market and emphasizes the need for vocational support policies for adults with ASD.
Additional file 4 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 4: Figure S4. Relative Wolbachia densities (ankyrin repeat domain to rps17) in the ovaries, carcass and eggs of Ae. aegypti in replicate group 2. A Wolbachia densities in the eggs vs the ovaries of Ae. aegypti in replicate group 2. B. Wolbachia densities in the eggs vs the carcass of Ae. aegypti in replicate group 2. n = 18 individuals.
Targeted parallel DNA sequencing detects circulating tumor-associated variants of the mitochondrial and nuclear genomes in patients with neuroblastoma
Creators: name: Riehl, Lara Maria
name: Mulaw, Medhanie Assmelash
name: Kneer, Katharina
name: Beer, Meinhard
name: Beer, Ambros
name: Barth, Thomas F. E.
name: Benes, Vladimir
name: Schulte, Johannes
name: Fischer, Matthias
name: Debatin, Klaus-Michael
name: Beltinger, Christian
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Mitochondrial and nuclear genomes
subject: Mutational signatures
subject: DDC 610 / Medicine & health
subject: Neuroblastoma
subject: Liquid biopsy
subject: Genome, Mitochondrial
subject: Neuroblastom
subject: Biopsie

description: Background The utility for liquid biopsy of tumor-associated circulating single-nucleotide variants, as opposed to mutations, of the mitochondrial (mt) and nuclear genomes in neuroblastoma (NB) is unknown. Procedure Variants of the mt and nuclear genomes from tumor, blood cells, and consecutive plasma samples of five patients with metastatic NB that relapsed or progressed were analyzed. Targeted parallel sequencing results of the mt genome, and of the coding region of 139 nuclear genes and 22 miRNAs implicated in NB, were correlated with clinical imaging and laboratory data. Results All tumors harbored multiple somatic mt and nuclear single nucleotide variants with low allelic frequency, most of them not detected in the circulation. In one patient a tumor-associated mt somatic variant was detected in the plasma before and during progressive disease. In a second patient a circulating nuclear tumor-associated DNA variant heralded clinical relapse. In all patients somatic mt and nuclear variants not evident in the tumor biopsy at time of diagnosis were found circulating at varying timepoints. This suggests either tumor heterogeneity, evolution of tumor variants or a confounding contribution of normal tissues to somatic variants in patient plasma. The number and allelic frequency of the circulating variants did not reflect the clinical course of the tumors. Mutational signatures of mt and nuclear somatic variants differed. They varied between patients and were detected in the circulation without mirroring the patients' course. Conclusions In this limited cohort of NB patients clinically informative tumor-associated mt and nuclear circulating variants were detected by targeted parallel sequencing in a minority of patients.
Additional file 5 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 5: Figure S5. Crossing point values of rps17 in the tissues of mothers (P1) and daughters (F1). These data pertain to Fig. 6 in the main text. A Crossing point values of rps17 of P1 in Ae. aegypti. B Crossing point values of rps17 of F1 in Ae. aegypti. Figure A has n = 31 individuals while B has n = 78 individuals. Bars indicate tissue means ± SE; ****P ≤ 0.0001.
A find of Viking-period silver brooches and fragments from Flusco, Newbiggin, Cumbria.
Creators: name: Richardson, Colin
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 35-44
description: Silver penannular brooches typical of the late ninth and early tenth centuries - distribution centred on the Irish Sea. Found by metal-detector in 1989, they were declared Treasure Trove in 1990 and sent to the British Museum for metallurgical and other analyses.