cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stellenwert von niedrigdosiertem Dopamin in der Prophylaxe oder Therapie des akuten Nierenversagens
Creators: name: Krämer, Bernhard K.
name: Böger, Carsten A.
name: Götz, Angela
name: Banas, Bernhard
Publisher: name: Universität Regensburg
Year: 2004
Subjects: subject: Acute renal failure – dopamine; prophylaxis; treatment; Akutes Nierenversagen; Dopamin; Prophylaxe; Therapie
subject: 610 Medizin

description: Low-dose dopamine increases both renal perfusion and sodium excretion in a dosedependent manner. These renal effects of dopamine have facilitated the widespread use of socalled “renal dose dopamine”. However, recent clinical trials have been unable to demonstrate efficacy of dopamine in the prophylaxis or treatment of acute renal failure in critical care patients or postoperatively. Therefore, dopamine definitely should no longer be used for prophylaxis/treatment of acute renal failure because of lack of efficacy, potential side effects of dopamine use, i.e., cardiac rhythm disorders/bacterial translocation, and in addition the associated high costs.
 Niedrigdosiertes Dopamin führt dosisabhängig zu einer renalen Vasodilatation, einer Steigerung der Diurese und einer Zunahme der renalen Natriumexkretion. Diese Wirkungen haben zum weitverbreiteten Einsatz von Dopamin in „Nierendosis“ beigetragen. Allerdings haben kürzlich durchgeführte klinische Studien die Wirksamkeit von Dopamin in der Prophylaxe und/oder Therapie eines akuten Nierenversagens im Rahmen von Intensivaufenthalten bzw. postoperativer Genese nicht bestätigen können. Bei fehlendem Wirksamkeitsnachweis, den mit der Dopamingabe verbundenen Risiken wie Rhythmusstörungen oder bakterieller Translokation sowie wegen der zusätzlichen Therapiekosten sollte Dopamin somit endgültig nicht mehr weder zur Prophylaxe noch zur Therapie des akuten Nierenversagens Verwendung finden.
Synthesis, Characterization, Hydrolytic Stability, Nickel(II) Chloride Complex and Anti-Parasitic Activity of Pyrene-Tethered Silatranes
Creators: name: Gurjaspreet Singh
name: Akshpreet Singh
name: Chowdhary, Kavita
name: Pinky Satija
name: Sanchita
name: Kalra, Pooja
name: Geetika Sharma
name: Sinha, Shweta
name: Sehgal, Rakesh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The known silatrane chemistry with polycyclic aromatic hydrocarbons (PAHs) has not been extensively investigated. The current study features synthesis and characterization of silatranes bearing pyrene substituent at the apical silicon site starting from 1-pyrenecarboxaldehyde and N-(3-(trimethoxysilyl)propyl)ethane-1,2-diamine. The synthesized silatranes were subjected to time-dependent hydrolysis study to examine their hydrolytic stability. In addition, one of the silatrane has been used to entrap nickel chloride to obtain complex of 1:1 composition. Mass, IR spectroscopic data and theoretical study revealed about the chelate structure of the complex in which silatrane acts as a bidentate ligand. The protozoans are cause of numerous infective diseases and so the article also assesses the anti-parasitic potential of the prepared compounds. Both the silatranes showed significant activity against Giardia lamblia and Entamoeba histolytica and very low IC50 values of (6) against G. lamblia and (7) against E. histolytica indicate their potential to act as efficient drug in comparison to standard drug, metronidazole.
Endovascular repair of proximal endograft collapse after treatment for thoracic aortic disease
Creators: name: Steinbauer, Markus G. M.
name: Stehr, Alexander
name: Pfister, Karin
name: Herold, Thomas
name: Zorger, Niels
name: Töpel, Ingolf
name: Paetzel, Christian
name: Kasprzak, Piotr M.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: We report two cases of proximal endograft collapse with an almost complete aortic occlusion after endovascular tube-graft treatment of thoracic aortic disease (thoracic aneurysm after a type B dissection, traumatic blunt aortic rupture) using the TAG Gore system. Oversizing of endografts is known to cause this complication. In our two cases, however, the oversizing was between 12% and 21.7%, which is less than the allowed oversizing of 25% that is recommended by the manufacturer. This endograft-related complication might be due to a poor alignment of the currently available endografts in highly angulated and tight aortic arches. In the first case, a combined endovascular and open emergent repair procedure achieved a reopening of the proximal endograft by proximal extension (TAG Gore). In the second case, proximal extension was not considered owing to a precise positioning of the endograft distal to the left carotid artery. A balloon-expanding Palmaz stent was therefore placed interventionally in the proximal part of the TAG graft to expand the endograft and to avoid another collapse of the device. This proximal endograft collapse has to be acknowledged as a potentially hazardous complication. We therefore recommend that the proximal part of thoracic endografts in the aortic arch should be closely monitored and we offer two possible endovascular solutions for resolving the problem of proximal endograft collapse.
A flow cytometric screening test for detergent-resistant surface antigens in monocytes
Creators: name: Wolf, Zsuzsanna
name: Orsó, Evelyn
name: Werner, Tobias
name: Boettcher, Alfred
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: detergent-resistant membranes; monocytes; flow cytometry; receptor cluster
subject: 610 Medizin

description: Rafts resemble cholesterol- and glycosphingolipid-enriched, liquid-ordered plasma membrane microdomains, showing resistance to nonionic detergents, and are involved in various cellular processes. In the present study, we have tested surface antigens on resting and lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes for their detergent resistance (i.e. raft-association), by flow cytometry. Constitutive (CD14, CD32, CD55), or LPS-induced (CD81) raft-association, and detergent solubility (i.e. exclusion of rafts) (CD71) of monocyte antigens in the presence of 0.01% Triton X-100 are clearly demonstrated. Flow cytometric detergent insolubility is a powerful tool for rapid screening the raft-association of monocyte antigens in a whole-blood assay.
V474 Car: A Rare Halo RS CVn Binary in Retrograde Galactic Orbit
Creators: name: Bubar, Eric J.
name: Mamajek, Eric E.
name: Jensen, Eric L. N.
name: Walter, Frederick M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the discovery that the star V474 Car is an extremely active, high velocity halo RS CVn system. The star was originally identified as a possible pre-main sequence star in Carina, given its enhanced stellar activity, rapid rotation (10.3 days), enhanced Li, and absolute magnitude that places it above the main sequence. However, its extreme radial velocity (264 km s$^{-1}$) suggested that this system was unlike any previously known pre-MS system. Our detailed spectroscopic analysis of echelle spectra taken with the CTIO 4-m finds that V474 Car is both a spectroscopic binary with orbital period similar to the photometric rotation period, and metal poor ([Fe/H] $\simeq -$0.99). The star's Galactic orbit is extremely eccentric (e $\simeq$ 0.93) with perigalacticon of only $\sim$0.3 kpc of the Galactic center - and its eccentricity and smallness of its perigalacticon are only surpassed by $\sim$0.05%, of local F/G-type field stars. The observed characteristics are consistent with V474 Car being a high velocity, metal poor, tidally-locked chromospherically active binary (CAB), i.e.\ a halo RS CVn binary, and one of only a few such specimens known.
description: Accepted to Astronomical Journal
Probabilistic verification and evaluation of Backoff procedure of the WSN ECo-MAC protocol
Creators: name: Zayani, Hafedh
name: Barkaoui, Kamel
name: Ayed, Rahma Ben
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Communication protocols and techniques are often evaluated using simulation techniques. However, the use of formal modeling and analysis techniques for verification and evaluation in particular for Wireless Sensor Networks (WSN) becomes a necessity. In this paper we present a formal analysis of the backoff procedure integrated in the medium access control protocol named ECo-MAC designed for WSN. We describe this backoff procedure in terms of discrete time Markov chains (DTMCs) and evaluated using the well known probabilistic model checker PRISM. After checking the different invariants of the proposed model, we study the effect of contention window length (in number of time contention unit) on the acceptable number of simultaneous senders in a neighborhood of a given receiver. The obtained quantitative results confirm those provided by the simulation using OPNET tool and justify the validity of the adopted value for the time contention unit TCU.
description: 15 Pages, IJWMN 2010
To kill or not to kill? : a discursive analysis of colonial and Islamic influences on blasphemy legislation in postcolonial Pakistan
Creators: name: Nahri, Syed Ahmed Faisal
Publisher: name: University of British Columbia
Year: 2018

description: At the time of independence, Pakistan inherited certain blasphemy laws along with the Indian Penal Code instituted by the British in 1860. After independence, additional blasphemy laws were introduced under a military regime in the 1980s. The postcolonial laws mirrored the colonial blasphemy legislation in important ways, but also differed significantly. Like their colonial precursors, the postcolonial blasphemy laws are (a) capacious in terms of what constitutes the offense and (b) require complainants to demonstrate that their “feelings” have been injured, which entails incitement of religious passion and violence that does not subside in favor of the judicial process. The postcolonial laws were designed moreover to appease certain religious political actors and a segment of the population. By means of these laws, an autocratic regime coopted and legitimized social violence in exchange for legitimacy. In the years following their legislation, these laws have been used to punish dissent and target members of minority communities. The laws have engendered unhealthy social mobilization and vigilante justice. The present work investigates colonial, Islamic traditional and imperial, and contemporary discursive influences that have shaped the blasphemy laws instituted in the 1980s. The characterization of the discursive and political climate in contemporary Pakistan is based on analysis of (a) interviews and video statements appearing on news and social media, and (b) semi-scholarly articles appearing in journals of religiopolitical organizations. The discussion of Islamic traditional and imperial influences is based on an examination of the Qur’an and important Islamic juristic texts on the subject. The impressions concerning the colonial legacy derive mostly from secondary scholarly works. Based on engagement with numerous primary and secondary sources in Arabic, English and Urdu, it is contended that the blasphemy laws introduced in Pakistan in the 1980s mirror certain features of precursor colonial laws, but also bear distinctive features that issue from a postcolonial Islamic discursive matrix consisting of a tide of Salafism that began in the 1970s, preoccupation with a narrow set of moral concerns and top-down approach to Islamic reform, and the desire to antagonize perceived adversaries of Islam and Pakistan.
Folgeerkrankungen nach gastrointestinalen Operationen
Creators: name: Zuber-Jerger, I.
name: Schölmerich, J.
name: Klebl, F.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Postgastrektomiesyndrom; Kurzdarmsyndrom; Lebertransplantation; Pankreaschirurgie; Pouchitis
subject: 610 Medizin

description: Gastrointestinal surgery may not only lead to early postoperative complications but also chronic consequences. These have therapeutic implications for affected patients. The kind and extent of surgical intervention determines the spectrum of postsurgical phenomena which may occur. These chronic consequences are due to changes in gastrointestinal anatomy, the synchronization of digestive processes, or the ability to digest and absorb food. In case of transplantation surgery, adverse effects of immunosuppression have to be considered. Sometimes, chronic consequences of surgical procedures are difficult to recognize. The knowledge of typical problems associated with gastrointestinal surgery is necessary to enable early and timely diagnosis and treatment. Some negative effects can be avoided by early therapeutic interventions. This article summarizes typical chronic consequences of gastrointestinal surgery. Operative Eingriffe am Verdauungstrakt können nicht nur durch frühe Komplikationen, sondern auch durch das Auftreten von Folgeerkrankungen für den Patienten therapeutisch relevante Konsequenzen haben. Das Spektrum zu bedenkender Folgeerscheinungen ist dabei abhängig von der Art und dem Ausmaß der durchgeführten Operation. Sie können auf Veränderungen der Anatomie, des zeitlichen Zusammenspiels der Organe des Intestinaltrakts oder der Fähigkeit zur Digestion und Absorption beruhen. Im Falle von Transplantationen kommen Komplikationen der Immunsuppression hinzu. Chronische Konsequenzen operativer Eingriffe sind gelegentlich schwer zu diagnostizieren. Kenntnisse über die typischen Folgeerkrankungen sind von Bedeutung, um eine frühzeitige Diagnosestellung und Therapieeinleitung zu ermöglichen. Manche negativen Folgen lassen sich durch rechtzeitige therapeutische Maßnahmen verhindern. Dieser Beitrag beleuchtet wichtige Folgeerkrankungen der gastrointestinalen Chirurgie.
First-order layering and critical wetting transitions in non-additive hard sphere mixtures
Creators: name: Hopkins, Paul
name: Schmidt, Matthias
Publisher: name: arXiv
Year: 2011
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Using fundamental-measure density functional theory we investigate entropic wetting in an asymmetric binary mixture of hard spheres with positive non-additivity. We consider a general planar hard wall, where preferential adsorption is induced by a difference in closest approach of the different species and the wall. Close to bulk fluid-fluid coexistence the phase rich in the minority component adsorbs either through a series of first-order layering transitions, where an increasing number of liquid layers adsorbs sequentially, or via a critical wetting transition, where a thick film grows continuously.
description: 4 pages, 4 figures
Additional file 1 of Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages
Creators: name: Mawhin, M. A.
name: Bright, R. G.
name: Fourre, J. D.
name: Vloumidi, E. I.
name: Tomlinson, J.
name: Sardini, A.
name: Pusey, C. D.
name: Woollard, K. J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Marine Biology

description: Additional file 1.
Reproducibility Scorecard to Assess Systems Biology Models
Creators: name: Tiwari, Krishna
name: Waltemath, Dagmar
name: Hermjakob, Henning
name: Malik-Sheriff, Rahuman
Publisher: name: Zenodo
Year: 2021
Subjects: Systems Biology
Mathematical modelling
Reproducibility
Computational Biology

description: Systems biology modelling involves the mathematical representation of biological processes to study complex system behaviour and was expected to be less affected by the reproducibility crisis. However, models often fail to reproduce and the reasons for the failure and prevalence were not fully understood. We analyzed 455 kinetic models published in 152 peer-reviewed journals. Most of these models were manually encoded from scratch to assess reproducibility. Our investigation revealed that 49% of the models could not be reproduced using the information provided in the manuscripts. With further effort, an additional 12% could be reproduced either by empirical correction or support from authors. The other 37% remained non-reproducible due to missing parameter values, missing initial concentration, or inconsistent model structure. Among the corresponding authors, we contacted <30% responded. Models from many life science journals failed to reproduce, revealing a common problem in the peer-review process. Hence, we proposed a reproducibility scorecard to assess each model and address the reproducibility crisis. The aim of this scorecard is to help evaluate the reproducibility of the systems biology model and its simulation. It consists of eight questions with a unit score for each “yes” as an answer. The higher the total score, the more reproducible the model is expected to be. All eight questions may not always be applicable and hence, on the scale of 8, a minimum score of 4 is recommended. Model authors, reviewers, and journal editors can assess each systems biology model in a manuscript using this scorecard to support the peer-review process. For details see Tiwari et al., 2021 Mol Sys Bio https://doi.org/10.15252/msb.20209982 and https://www.ebi.ac.uk/biomodels/reproducibility.
description: {"references": ["Tiwari et al. \"Reproducibility in systems biology modelling.\" Molecular systems biology vol. 17,2 (2021): e9982. doi:10.15252/msb.20209982"]}
Sign changes of $π(x, q, 1) - π(x, q, a)$
Creators: name: Schlage-Puchta, Jan-Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11N13

description: It is known, that under the assumption of the generalized Riemannian hypothesis, the function $π(x, q, 1) - π(x, q, a)$ has infinitely many sign changes. In this article we give an upper bound for the least such sign change. Similarly, assuming the Riemannian hypothesis we give a lower bound for the number of sign changes of $π(x)-\li x$. The implied results for the least sign change are weaker then those obtained by numerical methods, however, our method makes no use of computations of zeros of the $ζ$-function.
title: Die Behandlung von Patienten mit schweren blasenbildenden Hauterkrankungen in einem Brandverletztenzentrum
Creators: name: Siemers, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Akut auftretende exfoliative Hauterkrankungen wie die toxische epidermale Nekrolyse (TEN) oder das Steven Johnson Syndrom (SJS) sind seltene Erkrankungen mit einer zum Teil hohen Morbidität und Mortalität. Bei der TEN findet sich histologisch eine subepidermale Blasenbildung, wodurch sich [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
title: Aktuelle Diagnostik- und Behandlungskonzepte bei Verbrühung/Verbrennung bei Kindern
Creators: name: Cruz, Diogo
name: Wild, Thomas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Kindliche Verbrennungen sind sehr häufige Verletzungen. Jährlich verbrennen sich mehr als 30.000 Kinder in Deutschland. Obwohl der Großteil ambulant betreut werden kann, werden jedes Jahr circa 6.000 stationär behandelt. In mehr als 70 % der Fälle handelt es sich um Verbrühungen.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Evaluation of a high-content screening fluorescence-based assay analyzing the pharmacological modulation of lipid homeostasis in human macrophages
Creators: name: Werner, Tobias
name: Liebisch, Gerhard
name: Grandl, Margot
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: high-content screening; fluorescence; lipid homeostasis
subject: 610 Medizin

description: BACKGROUND: For understanding cholesterol and phospholipid efflux pathways there is a need for cellular fluorescence-based high-content screens (HCS) to investigated the cholesterol and phospholipid content in human macrophages. METHODS: Making use of fluorescence imaging based on HCS we have developed a tool to evaluate new agents that can act as inducers of cholesterol efflux. The fluorescence assay is based on the different staining patterns of cholesterol-loaded (E-LDL) and deloaded (HDL3) differentiated monocytes by the saturated, fluorescent lipid probe (1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine)-tetramethyl-rhodamin. RESULTS: Morphologic examination and statistical evaluation of the staining pattern such as gray value, threshold area, shape factor and the spot size distribution provides evidence for a significant pattern change when cholesterol enriched and cholesterol depleted differentiated monocytes were imaged.
Additional file 2 of Chronic kidney disease mediates cardiac dysfunction associated with increased resident cardiac macrophages
Creators: name: Mawhin, M. A.
name: Bright, R. G.
name: Fourre, J. D.
name: Vloumidi, E. I.
name: Tomlinson, J.
name: Sardini, A.
name: Pusey, C. D.
name: Woollard, K. J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Marine Biology

description: Additional file 2.
title: Update konservative und operative Behandlung bei Verbrennungen
Creators: name: Winter, Jochen
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Kleinere Verbrennungen treten als Bagatellverletzungen sehr häufig auf und bedürfen in der Regel keiner speziellen ärztlichen Behandlung. Großflächige und tiefere Verbrennungen sind glücklicherweise viel seltener, sind jedoch in der Therapie sehr anspruchsvoll.    Thema[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Iron lines in model disk spectra of galactic black hole binaries
Creators: name: Rozanska, A.
name: Madej, J.
name: Konorski, P.
name: Sadowski, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present angle-dependent, broad-band intensity spectra from accretion disks around black holes of 10 M$_\odot$. In our computations disks are assumed to be slim, which means that the radial advection is taken into account while computing effective temperature of the disk. We attempt to reconstruct continuum and line spectra of X-ray binaries in soft state, i.e. dominated by the disk component of multitemperature shape. We follow how the iron line complex depends on the external irradiation, an accretion rate and a black hole spin. Full radiative transfer is solved including effects of Compton scattering, free-free and all important bound-free transitions of 10 main elements. Moreover, we include here the fundamental series of iron lines from helium-like and hydrogen-like ions, and fluorescent K$_α$ and K$_β$ lines from low ionized iron. We consider two cases: non-rotating black hole, and black hole rotating with almost maximum spin a=0.98, and obtain spectra for five accretion disks from hard X-rays to the infrared. In non irradiated disks, resonance lines from He-like and H-like iron appear mostly in absorption. Such disk spectra exhibit limb-darkening in the whole energy range. External irradiation causes that iron resonance lines appear in emission. Furthermore, depending on disk effective temperature, fluorescent iron K$_α$ and K$_β$ lines are present in disk emitting spectra.All models with irradiation exhibit limb-brightening in their X-ray reflected continua. We show, that the disk around stellar black hole itself is hot enought to produce strong absorption resonance lines of iron. Emission lines can be observed only if heating by external X-rays dominates over thermal processess in hot disk atmosphere. Irradiated disks are usually brighter in X-ray continuum when seen edge on, and fainter when seen face on.
description: 10 pages, 9 figures, accepted in A&A
Early and late transition metal complexes featuring 1,3-N,O-chelates : development of homogenous catalysts for the α-alkylation of amines via hydroaminoalkylation
Creators: name: Brandt, Jason W.
Publisher: name: University of British Columbia
Year: 2019

description: This thesis details the development of transition-metal complexes that are utilized as precatalysts for catalytic hydroaminoalkylation chemistry. Hydroaminoalkylation is the activation of an α-C(sp³)–H of an amine, and subsequent addition across a C–C unsaturation. This results in α-alkylated amines in a 100% atom-economical reaction, while avoiding amine protection/deprotection strategies. A series of 2-pyridonate chloro tris(dimethylamido) tantalum complexes have been synthesized and tested for the hydroaminoalkylation of alkenes with secondary amines. These complexes were found to exhibit high reactivity for a broad range of internal alkene substrates and represent the first, general hydroaminoalkylation of cyclic and linear internal alkenes that occurs without isomerization of the C=C double bond. Further study supports the assertion that minimized steric parameters of the 2-pyridonate and chloro ligands allow for reactivity with sterically demanding internal alkenes. Kinetic studies and deuterium labeling experiments reveal a complex kinetic profile and provide evidence for off-cycle equilibria that dominate catalytic activity. Complementary to this work, an alternative 1,3-N,O-chelating phosphoramidate ligand framework was explored to synthesize Nb complexes for hydroaminoalkylation. A variety of monophosphoramidate tetrakis(dimethylamido) Nb complexes were synthesized, as well as bis(phosphoramidate) niobaziridines, which are proposed as intermediates for the hydroaminoalkylation mechanism. The optimal precatalyst system was found to be an in situ preparation of 2:1 phosphoramide:Nb(NMe₂)₅. This offers comparable results to analogous phosphoramidate Ta complexes, but with a significantly different phosphoramidate ligand set. New cationic complexes of Ru, Rh, and Ir were synthesized featuring a bidentate κ²- P,N- phosphino-2-pyridonate ligand. These complexes were not viable precatalysts for hydroaminoalkylation, but were found to promote the stoichiometric dehydrogenation of amines to generate cationic metal hydrides. Analogous cationic complexes of 1,3-N,O-chelating 2- pyridonate complexes were prepared in situ and were found to catalyzed the reaction of dibenzylamine to tribenzylamine. A 2-pyridonate Ru complex was found to catalyze the dehydrogenation of benzylamine to the corresponding imine in the presence of isoprene, which acted as the hydrogen acceptor. Attempted hydroaminoalkylation reactions with non-arene supported 2-pyridonate complexes did not result in catalysis. These results provide insight into the use of late-transition metal complexes in amine activation and reactivity.
Synthesis, Characterization, Hydrolytic Stability, Nickel(II) Chloride Complex and Anti-Parasitic Activity of Pyrene-Tethered Silatranes
Creators: name: Gurjaspreet Singh
name: Akshpreet Singh
name: Chowdhary, Kavita
name: Pinky Satija
name: Sanchita
name: Kalra, Pooja
name: Geetika Sharma
name: Sinha, Shweta
name: Sehgal, Rakesh
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The known silatrane chemistry with polycyclic aromatic hydrocarbons (PAHs) has not been extensively investigated. The current study features synthesis and characterization of silatranes bearing pyrene substituent at the apical silicon site starting from 1-pyrenecarboxaldehyde and N-(3-(trimethoxysilyl)propyl)ethane-1,2-diamine. The synthesized silatranes were subjected to time-dependent hydrolysis study to examine their hydrolytic stability. In addition, one of the silatrane has been used to entrap nickel chloride to obtain complex of 1:1 composition. Mass, IR spectroscopic data and theoretical study revealed about the chelate structure of the complex in which silatrane acts as a bidentate ligand. The protozoans are cause of numerous infective diseases and so the article also assesses the anti-parasitic potential of the prepared compounds. Both the silatranes showed significant activity against Giardia lamblia and Entamoeba histolytica and very low IC50 values of (6) against G. lamblia and (7) against E. histolytica indicate their potential to act as efficient drug in comparison to standard drug, metronidazole.
Ezetimib influences the expression of raft-associated antigens in human monocytes
Creators: name: Orsó, Evelyn
name: Werner, Tobias
name: Wolf, Zsuzsanna
name: Bandulik, Sascha
name: Kramer, Werner
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: CD13; Ezetimib; detergent-resistant microdomain
subject: 610 Medizin

description: Aminopeptidase N (CD13) was recently identified as a molecular target of the cholesterol absorption inhibitor Ezetimib. Regarding that CD13 is expressed in lipid rafts of monocytic cells, we have investigated whether Ezetimib influences raft function in these cells. Expression of raft-associated antigens (CD11b, CD13, CD14, CD16, CD36, and CD64) was followed by flow cytometry and/or immunoblot in human monocyte-derived macrophages in response to in vitro administration of Ezetimib. Cellular redistribution of CD13 was assessed by confocal imaging. Ezetimib significantly decreased the surface expression of CD13, CD16, CD64, and CD36; furthermore, it induced a shift of CD13 from plasma membrane to intracellular vesicles, and thus it quite likely modulated monocytic raft-assembly.
title: Der Einsatz von Epicite Hydro® in der Brandverletzten-Behandlung
Creators: name: Kamolz, Lars-Peter
name: Funk, Martin
name: Tuca, Alexandru
name: Holzer, Judith
name: Nischwitz, Sebastian
name: Bernardelli de Mattos, Ives
name: Groeber-Becker, Florian
name: Birngruber, Thomas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Bei der konservativen Behandlung von Verbrennungen kommen sehr häufig Verbandsmaterialien, die eine antibakterielle Wirkung aufweisen, zum Einsatz. Bakterielle Zellulose (BZ) ist chemisch identisch mit pflanzlicher Zellulose, aber frei von Nebenprodukten. Sie weist aber isoliert nur[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Association between serum ferritin and the insulin resistance syndrome in a representative population
Creators: name: Wrede, C. E.
name: Buettner, R.
name: Bollheimer, L. C.
name: Schölmerich, J.
name: Palitzsch, K.-D.
name: Hellerbrand, C.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: OBJECTIVE: Unexplained hepatic iron overload with increased serum ferritin (SF) values has been associated with the insulin resistance syndrome (IRS), defined by the presence of one or more of the following criteria: increased body mass index (BMI), diabetes, hyperlipidemia or hypertension. However, as yet the association between IRS and SF in a representative population has not been investigated. METHODS: The study subjects participated in a nationwide epidemiological survey on metabolic disorders in the adult German population. The 1200 probands included in this study are representative of the German population. To eliminate major causes of secondary iron overload, 114 (9.5%) subjects with excessive alcohol consumption and 16 (1.5%) subjects with serological evidence for hepatitis B or C were excluded. For all remaining 1070 probands, complete clinical data of SF, HbA1c, known diabetes, BMI, cholesterol, high-density lipoprotein-cholesterol and blood pressure were available. RESULTS: SF values were significantly increased in men and women with high BMI (> 25 kg/m2), increased cholesterol (> 200 mg/dl), and increased systolic (> 160 mmHg) blood pressure, in women with diabetes, and in men with increased diastolic (> 95 mmHg) blood pressure. Furthermore, there was a significant correlation between the number of IRS criteria and SF. CONCLUSIONS: This study shows a significant correlation between SF and the presence of IRS criteria in a large representative population. Interestingly, the severity of the IRS seems to be associated with increased SF levels suggesting a causal connection. Further studies are required to investigate the pathophysiological mechanism and consequences of increased SF levels in patients with IRS.
Effects of quark matter nucleation on the evolution of proto-neutron stars
Creators: name: Bombaci, Ignazio
name: Logoteta, Domenico
name: Providencia, Constanca
name: Vidana, Isaac
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: (Abridged) A phase of strong interacting matter with deconfined quarks is expected in the core of massive neutron stars. If this deconfinement phase transition is of the first order then it will be triggered by the nucleation of a critical size drop of the stable quark phase in the metastable hadronic phase. Within these circumstances it has been shown that cold pure hadronic compact stars above a threshold value of their gravitational mass are metastable with respect to the "decay" to quark stars (compact stars made at least in part of quark matter). This stellar conversion process liberates a huge amount of energy, and it could be the energy source of some of the long GRBs. The main goal of the present work is to establish whether a newborn hadronic star (proto-hadronic star) could survive the early stages of its evolution without "decaying" to a quark star. To this aim, we study the nucleation process of quark matter in hot beta-stable hadronic matter, with and without trapped neutrinos. We calculate and compare the nucleation rate and the nucleation time due to thermal and quantum nucleation mechanisms. We compute the crossover temperature above which thermal nucleation dominates the finite temperature quantum nucleation mechanism. We next discuss the consequences of quark matter nucleation for the physics and the evolution of proto-neutron stars. We introduce the new concept of limiting conversion temperature and critical mass M_cr for proto-hadronic stars, and we show that proto-hadronic stars with a mass M < M_cr could survive the early stages of their evolution without decaying to a quark star. We extend the concept of maximum mass of a "neutron star" with respect to the classical one introduced by Oppenheimer & Volkoff to account for the existence of two distinct families of compact stars (hadronic stars and quark stars) as predicted by the present scenario.
description: Accepted for publication in Astronomy and Astrophysics
Additional file 1 of Moderate physical activity may not decrease the risk of cardiovascular disease in persistently overweight and obesity adults
Creators: name: Tian, Qiuyue
name: Wang, Biyan
name: Chen, Shuohua
name: Wu, Shouling
name: Wang, Youxin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Baseline characteristics of participants according trajectory groups for CVDs outcome. Table S2. Baseline characteristics of participants according trajectory groups for all-cause mortality outcome. Table S3. The association of the trajectory groups with CVDs and all-cause mortality stratified subgroups.
title: Möglichkeiten podologischer Präventionsstrategien bei Läsionen am Fuß
Creators: name: Kuberka-Wiese, Christine
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Wunden am Fuß stellen besonders für mobile Patienten eine Einschränkung des alltäglichen Lebens dar. Die Einschränkung entsteht durch die Behandlungsmaßnahmen oder durch die Wunde selbst.     Welche Rolle können Podologen durch ihre Fertigkeiten und Kompetenzen übernehmen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Endothelial apoptosis and circulating endothelial cells after bypass grafting with and without cardiopulmonary bypass
Creators: name: Schmid, Franz-Xaver
name: Vudattu, Nalini
name: Floerchinger, Bernhard
name: Hilker, Michael
name: Eissner, Günther
name: Hoenicka, Markus
name: Holler, Ernst
name: Birnbaum, Dietrich E.
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: Endothelial cell apoptosis; Circulating endothelial cells; Cardiopulmonary bypass; OPCAB surgery
subject: 610 Medizin

description: OBJECTIVE: We compared profiles of the numbers of circulating endothelial cells (CEC) and the apoptosis-inducing capacity of serum samples on human endothelial cells (hEC) in on-pump and off-pump coronary artery bypass grafting (CABG) patients. METHODS: Blood samples from 30 patients undergoing CABG (randomly assigned to two groups: 15 patients off-pump and 15 on-pump (cardiopulmonary bypass, CPB)) were collected after induction of anesthesia (preoperatively), at weaning from CPB/end of bypass grafting (0 h), and 1, 6, 12, 24, and 48 h afterwards. CEC were isolated with immunomagnetic anti-CD146-coated Dynabeads, and counted in a Nageotte chamber. The apoptosis-inducing activity of serum samples on hEC was examined by a tissue culture assay system. Apoptotic and normal cells were identified using phase contrast/fluorescence microscopy after DNA dye staining. RESULTS: CEC numbers and proportions of apoptotic hEC were significantly elevated during and after surgery in both groups (p<0.01). Compared with the on-pump group, CEC and proportions of apoptotic hEC were significantly lower (p=0.04 and p=0.03, respectively) in patients having CABG performed off-pump. Starting at comparable baseline levels, the mean CEC-number was highest at 6h postoperatively with 81.9 ml(-1) (range, 44-141) for on-pump patients and 63.3 ml(-1) (range, 48-105) for off-pump patients. hEC apoptosis peaked also at T4: 16.5+/-2.8% versus 11.3+/-2.2%. In both groups, CEC numbers and proportions of endothelial apoptosis were still elevated at 48 h after surgery. CONCLUSION: The number of circulating endothelial cells and apoptotic endothelial cell death are markers of endothelial activation and damage during CABG. This study provides evidence that CABG with the use of CPB in comparison to OPCAB surgery is associated with a significantly more pronounced endothelial response in the immediate postoperative period.
title: Differenzialdiagnose des Ulcus cruris
Creators: name: Aschoff, Roland
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Das Ulcus cruris stellt mit 1% ein häufiges Krankheitsbild bei Erwachsenen in Mitteleuropa dar. Die Ursachen können vielfältig sein. Da sich hinter einem Ulcus cruris eine große ätiologische Vielfalt verbirgt, ist eine gründliche Diagnostik entscheidend, um eine optimale[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Reconciling the X(4630) with the Y(4660)
Creators: name: Guo, Feng-Kun
name: Haidenbauer, Johann
name: Hanhart, Christoph
name: Meißner, Ulf-G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Belle Collaboration observed an enhancement called X(4630) in the Lambda_c^+ Lambda_c^- mass distribution using initial state radiation. We demonstrate that the enhancement could be consistent with the psi'f_0(980) molecular picture of the Y(4660) taking into account the Lambda_c^+ Lambda_c^- final state interaction. To test the hypothesis that the X(4630) and Y(4660) are the same molecular state, we give predictions for its spin partner, the eta_c'f_0(980) molecule. High statistic measurements of the B decays into the K Lambda_c^+ Lambda_c^- and K eta_c' pi^+ pi^- are strongly recommended.
description: 9 pages
title: Adipositas und Wunde
Creators: name: Esters, Jan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Die plastisch-chirurgischen Maßnahmen zur Wiederherstellung und funktionellen Rekonstruktion der Körpersilhouette nach massiver Gewichtsreduktion definiert den heutigen Begriff der postbariatrischen Chirurgie. Aufgrund des Vorliegens medizinsicher Indikationen grenzt sich die postbariatrische[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
High density lipoprotein modulates platelet function
Creators: name: Barlage, Stefan
name: Boettcher, Dorothee
name: Boettcher, Alfred
name: Dada, Ashraf
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: HDL; platelet; ABCA1; membrane raft
subject: 610 Medizin

description: BACKGROUND: Platelet activation by atherogenic lipoproteins can be antagonized by high density lipoprotein (HDL), probably via interaction with the ATP-binding cassette transporter A1 (ABCA1). METHODS: ABCA1 expression and its association with cholesterol rich membrane domains was analyzed by mRNA and Western blot analysis. HDL effects on platelet receptor clustering were analyzed by flow cytometric analysis of fluorescence resonance energy transfer between fluorochrome-labeled antibodies. RESULTS: ABCA1 expression increased upon megakaryocytic differentiation of human stem cells and ABCA1 protein partially associated to LubroIWX-resistant membrane domains. Plasma HDL-cholesterol in healthy donors negatively correlated to the platelet membrane cholesterol content. Receptor cluster analysis revealed a decrease in the association of Gplb and FcgammaRII upon incubation of platelets with HDL3. CONCLUSION: Our results suggest that HDL modulates platelet reactivity by altering lipid raft associated receptor clustering.
The equation $ω(n)=ω(n+1)$
Creators: name: Schlage-Puchta, Jan-Christoph
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11N37

description: We prove that there are infinitely many integers $n$ such that $n$ and $n+1$ have the same number of distinct prime divisors.
description: The result is no obsolete: Buttkewitz found a non-computational proof, and the Goldston-Pintz-Yildirim-sieve yields more precise information
Additional file 2 of The oncologic safety and accuracy of indocyanine green fluorescent dye marking in securing the proximal resection margin during totally laparoscopic distal gastrectomy for gastric cancer: a retrospective comparative study
Creators: name: Yoon, Byung Woo
name: Lee, Woo Yong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology

description: Additional file 2. Supplementary Table 1. The proximal resection margins before and after propensity score matching.
Experimental investigation of tunneling times using Bose-Einstein condensates
Creators: name: Ciampini, Donatella
name: Morsch, Oliver
name: Arimondo, Ennio
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The time it takes a quantum system to complete a tunneling event (which in the case of cross-barrier tunneling can be viewed as the time spent in a classically forbidden area) is related to the time required for a state to evolve to an orthogonal state, and an observation, i.e., a quantum mechanical projection on a particular basis, is required to distinguish one state from another. We have performed time-resolved measurements of Landau-Zener tunneling of Bose-Einstein condensates in accelerated optical lattices, clearly resolving the steplike time dependence of the band populations. The use of different protocols enabled us to access the tunneling probability, in two different bases, namely, the adiabatic basis and the diabatic basis. The adiabatic basis corresponds to the eigenstates of the lattice, and the diabatic one to the freeparticle momentum eigenstates. Our findings pave the way towards more quantitative studies of the tunneling time for LZ transitions, which are of current interest in the context of optimal quantum control and the quantum speed limit.
description: 5 pages, 2 figures. Fifth International Workshop DICE2010, September 13-17 2010
title: Die Top 10 in der Wundbehandlung
Creators: name: Bauernfeind, Gonda
name: Strupeit, Steve
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Die Organisation der Wundheilung bedarf einem gut koordinierten Behandlungspfad. Von Beginn an müssen die Therapieziele im Fokus stehen, darauf folgt die Diagnostik und die umfassende Therapie der Grunderkrankung. Die Lokaltherapie der chronischen Wunden folgt abgesehen von Ausnahmefällen [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 9. Mitteldeutscher Wundkongress
Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages
Creators: name: Ugocsai, Peter
name: Barlage, Stefan
name: Dada, Ashraf
name: Schmitz, Gerd
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: CD163; heme oxygenase-1; inflammatory cytokines
subject: 610 Medizin

description: Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased availability of HbHp complexes triggers the upregulation of surface CD163, and also results in a dose-dependent secretion of IL-6 and IL-10.