cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
National education and training policy and future job openings by occupation and industry
Creators: name: Shah, Chandravadan
Publisher: name: Monash University
Year: 2021
Subjects: subject: Economics
subject: 140204 Economics of Education
subject: FOS: Economics and business
subject: 140211 Labour Economics

description: Labor market information is important for the efficient operation of dynamic and complex labor and training markets. Such information has an important role in reducing skills imbalances, which research has shown to have an adverse effect on productivity growth. An important part of this information includes forecasts of future job openings by occupation and industry. This chapter provides an outline for producing such forecasts in the Australian context. It combines forecasts of employment growth, produced using a computable general equilibrium model, with replacement demand forecasts to produce this information.
Geomorphology of the Hohsand basin (Western Italian Alps)
Creators: name: Colombo, Nicola
name: Paro, Luca
name: Godone, Danilo
name: Fratianni, Simona
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The 1:10,000 scale geomorphological map of the Hohsand basin (Piemonte Region, Italy) encompasses an area of 18 km2 (elevation range: 2300 ÷ 3374 m a.s.l.) where deposits and landforms linked to different processes (glacial, periglacial, gravitational, weathering and surface water) have been distinguished. This basin hosts one of the largest glacial areas of the Western Italian Alps in which it is possible to observe and study the relationships between glacial and periglacial processes. Indeed, due to climate change, Hohsand basin has highlighted an impressive glacier retreat since the end of the Little Ice Age (1600–1900s). In recently deglaciated areas, newly developed periglacial processes and landforms have been recognised and mapped in detail at 1:3,000 scale. All these maps, including a synthesis map at 1:25,000 illustrating the distribution of glacial deposits, have been produced using multitemporal photographic interpretation of aerial images and more recent digital orthoimages, and systematic field surveys performed during the summers 2012 and 2013. The cartographic results provide information about the geomorphological setting of this high-altitude alpine zone through a detailed representation of the genetically different landforms and deposits. Moreover, the in-depth geomorphological analysis of landforms related to glacial and periglacial environments allow understanding of the dynamic interaction between these two typical alpine systems in the present context of climate change.
Age-dependent and independent changes in attention-deficit/hyperactivity disorder (ADHD) during spatial working memory performance
Creators: name: Bollmann, Steffen
name: Ghisleni, Carmen
name: Simon-Shlomo Poil
name: Martin, Ernst
name: Eich-Höchli, Dominique
name: Klaver, Peter
name: Michels, Lars
name: Brandeis, Daniel
name: Ball, Juliane
name: O'Gorman, Ruth
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cell Biology
subject: Medicine

description: Objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with spatial working memory as well as frontostriatal core deficits. However, it is still unclear how the link between these frontostriatal deficits and working memory function in ADHD differs in children and adults. This study examined spatial working memory in adults and children with ADHD, focusing on identifying regions demonstrating age-invariant or age-dependent abnormalities. Methods: We used functional magnetic resonance imaging to examine a group of 26 children and 35 adults to study load manipulated spatial working memory in patients and controls. Results: In comparison to healthy controls, patients demonstrated reduced positive parietal and frontostriatal load effects, i.e., less increase in brain activity from low to high load, despite similar task performance. In addition, younger patients showed negative load effects, i.e., a decrease in brain activity from low to high load, in medial prefrontal regions. Load effect differences between ADHD and controls that differed between age groups were found predominantly in prefrontal regions. Age-invariant load effect differences occurred predominantly in frontostriatal regions. Conclusions: The age-dependent deviations support the role of prefrontal maturation and compensation in ADHD, while the age-invariant alterations observed in frontostriatal regions provide further evidence that these regions reflect a core pathophysiology in ADHD.
Psychological constructs in driving automation: a consensus model and critical comment on construct proliferation
Creators: name: Heikoop, Daniël D.
name: Winter, Joost C.F. De
name: Arem, Bart Van
name: Stanton, Neville A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: As automation in vehicles becomes more prevalent, the call for understanding the behaviour of the driver while driving an automated vehicle becomes more salient. Although a variety of driver behaviour models exist, and various psychological constructs have been said to be influenced by automation, an empirically testable psychological model of automated driving has yet to be developed. Building upon Stanton and Young's model of driving automation, this article presents an updated model of interrelated psychological constructs. The proposed model was created based upon a systematic literature search of driving automation papers and a subsequent quantification of the number of reported links between a selected set of psychological constructs. A secondary aim of this article is to reach consensus in the use of psychological constructs regarding driving automation. Henceforth special attention is paid to resolving the issue of construct proliferation.
GHRForum_Youth_self_emp_9_11_2021_shah.pdf
Creators: name: Shah, Chandravadan
Publisher: name: Monash University
Year: 2021
Subjects: subject: 140211 Labour Economics
subject: FOS: Economics and business
subject: Sociology
subject: FOS: Sociology
subject: 140204 Economics of Education

description: Youth unemployment or underemployment are ‘wicked’ problems all around the world. They lead to a poor start in the working life of young people in terms of future income, housing, health and wellbeing and retirement income. Self-employment and youth entrepreneurship have been proposed as part of a suite of measures to address these problems. These two terms have different meanings depending on the context as not all self-employment can be considered an entrepreneurial activity. Self-employment is often the predominant form of work in most developing countries, not from choice but due to necessity. There is increasing youth self-employment in the rapidly expanding ‘gig’ or digital platform economy which pervades most countries. Many argue that much of the work arrangements between the platforms and workers can be characterised as ‘forced’ self-employment and is of concern in many countries, some of which have responded with regulation and legislation. Youth self-employment is thus highly contextual requiring varied public policy responses. This paper briefly describes what we know about youth self-employment and possible issues that public policy should address.
Role reversals: non-canonical roles for immune and non-immune cells in the gut
Creators: name: LE Tearle, Jacqueline
name: Tang, Adelynn
name: Vasanthakumar, Ajithkumar
name: James, Kylie R
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine

description: The intestine is home to an intertwined network of epithelial, immune, and neuronal cells as well as the microbiome, with implications for immunity, systemic metabolism, and behavior. While the complexity of this microenvironment has long since been acknowledged, recent technological advances have propelled our understanding to an unprecedented level. Notably, the microbiota and non-immune or structural cells have emerged as important conductors of intestinal immunity, and by contrast, cells of both the innate and adaptive immune systems have demonstrated non-canonical roles in tissue repair and metabolism. This review highlights recent works in the following two streams: non-immune cells of the intestine performing immunological functions; and traditional immune cells exhibiting non-immune functions in the gut.
1D profile of a cosmic volume from z=0 to z=1
Creators: name: Vazza, Franco
Publisher: name: http://b2share.eudat.eu
Year: 2016
Subjects: MHD
cosmological simulations
extragalactic magnetic fields

description: 1-dimensional profile of simulated fields for long beams through a simulated volume from z=0 to z=1. Each dataset is a column formatted file containing: a) x-position [kpc] b) gas density [g/cm^3] c) gas temperature [K] d) magnetic field, absolute value [G] all quantities are in physical units. The data are derived from a 200 Mpc simulation with ENZO-MHD, with a root grid of 2400^3 cells. 1000 indipendent line of sights have been generated from this dataset (combining the data from the z=0, z=0.5 and z=1.0 snapshots), each of which sample the cosmic volume from z=0 to z=1.
More details can be found in
http://cosmosimfrazza.myfreesites.net/radio-web and
http://adsabs.harvard.edu/abs/2015arXiv150308983V
Ibuprofen loading and release in amphiphilic peptide FA32 and its derivatives: a coarse-grained molecular dynamics simulation study
Creators: name: Thota, Naresh
name: Zhongqiao Hu
name: Jianwen Jiang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A molecular dynamics simulation study is reported to investigate the loading and release of ibuprofen (IBU) in amphiphilic peptide (AF)6H5K15 (FA32) and its derivatives (F12H5K15 and F16H5K15). The peptides are represented by the MARTINI coarse-grained model, and a similar model is developed here for IBU. Upon the loading of IBU in FA32, quasi-spherical core/shell structured micelles are formed. IBU is predominantly located in the hydrophobic core and covered by Phe and Ala residues, while Lys is in the hydrophilic shell. With increasing concentration of IBU, the micelles become larger due to increased hydrophobic interactions. In FA32 derivatives, the loading of IBU leads to different morphologies; particularly, a well-structured nanofibre is formed in F16H5K15. Upon pH change, the release of IBU from FA32 micelles is found to be slower than from F16H5K15 nanofibre, suggesting the former is better in controlled release. The simulation study reveals that IBU-loaded morphology can be altered by changing the type of peptide and has a significant effect on IBU release profile. This bottom-up insight might be useful in the rational design of carriers for efficient drug loading and release.
Psychological constructs in driving automation: a consensus model and critical comment on construct proliferation
Creators: name: Heikoop, Daniël D.
name: Winter, Joost C.F. De
name: Arem, Bart Van
name: Stanton, Neville A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: As automation in vehicles becomes more prevalent, the call for understanding the behaviour of the driver while driving an automated vehicle becomes more salient. Although a variety of driver behaviour models exist, and various psychological constructs have been said to be influenced by automation, an empirically testable psychological model of automated driving has yet to be developed. Building upon Stanton and Young's model of driving automation, this article presents an updated model of interrelated psychological constructs. The proposed model was created based upon a systematic literature search of driving automation papers and a subsequent quantification of the number of reported links between a selected set of psychological constructs. A secondary aim of this article is to reach consensus in the use of psychological constructs regarding driving automation. Henceforth special attention is paid to resolving the issue of construct proliferation.
E-pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for chronic kidney disease
Creators: name: Selvaraman Nagamani
name: Karthikeyan Muthusamy
name: J. John Marshal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Chronic kidney disease (CKD) is a prominent health issue reported globally. The level of the vitamin D receptor (VDR) and cytochrome P450 enzyme 24-hydroxylase (CYP24A1) are crucial in the pathogenesis of secondary hyperparathyroidism (sHPT) in CKD. An elevated expression of the CYP24A1 leads to the deficiency of vitamin D and resistance to vitamin D therapy. Hence, VDR agonists and CYP24A1 antagonists are suggested to CKD patients for the management of biochemical complications. CTA-018 is a recently reported analog and acts as a potent CYP24A1 inhibitor. It inhibits CYP24A1 with an IC50 27 ± 6 nM, about 10 times more potentially than the non-selective inhibitor ketoconazole (253 ± 20 nM), and it is also been reported to induce the VDR expression. Thus, CTA-018 is under clinical trial among CKD patients. In this study, combined molecular docking and pharmacophore filtering were employed to identify compounds better than CTA-018. A huge set of 9127 compounds from Sweet Lead database were docked into the active site of VDR using Glide XP program. E-pharmacophore was developed from both the targets along with CTA-018. The compounds retrieved from the two different pharmacophore-based screening were re-docked into the active site of CYP24A1. The hits that bind well at both the active sites and matched with the pharmacophore models were considered as possible dual functional molecules against VDR and CYP24A1. Further, molecular dynamics simulation and subsequent energy decomposition analyses were also performed to study the role of specific amino acids in the active site of both VDR and CYP24A1.
Computational predictions of cocrystal formation: A benchmark study of 28 assemblies comparing five methods from high-throughput to advanced models
Creators: name: Fox, Robert
name: Klug, Joaquin
name: THOMPSON, DAMIEN
name: Reilly, Anthony
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Cocrystals are assemblies of more than one type of molecule stabilized through non-covalent interactions. They are promising materials for improved drug formulation in which the stability, solubility, or biocompatibility of the active pharmaceutical ingredient (API) is improved by including a coformer. In this work, a range of density functional theory (DFT) and density functional tight binding (DFTB) models are systematically compared for their ability to predict the lattice enthalpy of a broad range of existing pharmaceutically relevant cocrystals. These range from cocrystals containing model compounds 4,40 -bipyridine and oxalic acid to those with the well benchmarked APIs of aspirin and paracetamol, all tested with a large set of alternative coformers. For simple cocrystals, there is a general consensus in lattice enthalpy calculated by the different DFT models. For the cocrystals with API coformers the cocrystals, enthalpy predictions depend strongly on the DFT model. The significantly lighter DFTB models predict unrealistic values of lattice enthalpy even for simple cocrystals.
National education and training policy and future job openings by occupation and industry
Creators: name: Shah, Chandravadan
Publisher: name: Monash University
Year: 2021
Subjects: subject: 140303 Economic Models and Forecasting
subject: FOS: Economics and business
subject: 140204 Economics of Education
subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences
subject: 140211 Labour Economics

description: Information about future job openings for new entrants can be important for those making decisions about what education and training courses to undertake. Such information has the potential to reduce skill imbalances in the labour market. This chapter describes a method used in Australia for producing medium term forecasts of job openings by occupation and industry.
FCC-ee Overview
Creators: name: Zimmermann, Frank
name: Zimmermann, Z.
name: Benedikt, Michael
name: Cerutti, F.
name: Ferrari, A.
name: Gutleber, J.
name: Härer, Bastian
name: Holzer, B.
name: Jensen, E.
Publisher: name: JACoW Publishing
Year: 2014

description: The FCC-ee is a proposed circular e+e- collider installed in a new 100 km tunnel delivering high luminosity to four experiments at centre-of-mass energies ranging from 91 GeV (Z pole) over 160 GeV (W threshold) and 240 GeV (H production) to 350 GeV (t physics). The FCC-ee design is pursued as part of the global Future Circular Collider (FCC) study, which regards the FCC-ee as a potential intermediate step towards a 100-TeV hadron collider, called FCC-hh, sharing the same tunnel infrastructure. We here report the FCC-ee design status.
Thermal stability study of Pd-composite membrane fabricated by surfactant induced electroless plating (SIEP)
Creators: name: Islam, Syed Z.
name: Vishwanath G. Deshmane
name: Ilias, Shamsuddin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology

description: Over the years, several different methods have been developed by modifying the conventional electroless plating (CEP) technique to fabricate dense thin Pd composite membranes with high H2 permselectivity. In this study, Pd composite membranes on macroporous stainless steel substrate (MPSS) were fabricated using CEP and novel surfactant induced electroless plating (SIEP) methods. The structural characteristics of CEP and SIEP fabricated Pd membranes were investigated before and after the heat treatment using SEM, XRD, EDS, and AFM techniques. The H2 permselectivity performance of the SIEP membranes was compared with that of CEP at different temperatures and trans-membrane pressures in the range of 523-823 K and 20-100 psi, respectively. The long-term thermal stability test of SIEP fabricated membranes was carried out on two different membranes, fabricated on MPSS substrates with and without oxide layer at 15 psi trans-membrane pressure and thermal cycling of 573-723-573 K. The microstructure analysis revealed that SIEP membranes have finer grains and diffused grain boundaries resulting in uniform, smooth, continuous, and pinhole free Pd-film. The SIEP membrane showed eight-fold higher H2 flux (1.7172 mol/m2/s) and four-fold higher H2 selectivity (~148) at 823 K and 100 psi trans-membrane pressure, compared to CEP membrane. Pd/MPSS membrane subjected to test for long-term performance and thermal cycling showed stable performance up to 1200 h while maintaining infinite H2 selectivity. Interestingly, although the thickness of Pd/oxi-MPSS (13.49 µm) membrane was higher than that of Pd/MPSS (11.6 µm) membrane, the H2 flux of Pd/oxi-MPSS membrane was two times higher than that of Pd/MPSS, attributed to the effective action of oxide layer as diffusion barrier.
Ibuprofen loading and release in amphiphilic peptide FA32 and its derivatives: a coarse-grained molecular dynamics simulation study
Creators: name: Thota, Naresh
name: Zhongqiao Hu
name: Jianwen Jiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A molecular dynamics simulation study is reported to investigate the loading and release of ibuprofen (IBU) in amphiphilic peptide (AF)6H5K15 (FA32) and its derivatives (F12H5K15 and F16H5K15). The peptides are represented by the MARTINI coarse-grained model, and a similar model is developed here for IBU. Upon the loading of IBU in FA32, quasi-spherical core/shell structured micelles are formed. IBU is predominantly located in the hydrophobic core and covered by Phe and Ala residues, while Lys is in the hydrophilic shell. With increasing concentration of IBU, the micelles become larger due to increased hydrophobic interactions. In FA32 derivatives, the loading of IBU leads to different morphologies; particularly, a well-structured nanofibre is formed in F16H5K15. Upon pH change, the release of IBU from FA32 micelles is found to be slower than from F16H5K15 nanofibre, suggesting the former is better in controlled release. The simulation study reveals that IBU-loaded morphology can be altered by changing the type of peptide and has a significant effect on IBU release profile. This bottom-up insight might be useful in the rational design of carriers for efficient drug loading and release.
PEDAGOGICAL PSYCHOLOGICAL ASPECTS OF MILITARY PATRIOTIC EDUCATION IN GENERAL SECONDARY EDUCATIONAL INSTITUTIONS
Creators: name: Abdurasulov, Jahongirmirzo
Publisher: name: Zenodo
Year: 2024

description: this article provides information about the concept of patriotic education and the national, historical basis for educating primary school students in the spirit of patriotism, the concept of educating young people in the spirit of military-patriotism.
title: 03_0532
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Zinc-induced heterodimer formation between metal-binding domains of intact and naturally modified amyloid-beta species: implication to amyloid seeding in Alzheimer’s disease?
Creators: name: Mezentsev, Yuri V.
name: Medvedev, Alexei E.
name: Kechko, Olga I.
name: Makarov, Alexander A.
name: Ivanov, Alexis S.
name: Mantsyzov, Alexey B.
name: Kozin, Sergey A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Computational Biology

description: Zinc ions and modified amyloid-beta peptides (Aβ) play a critical role in the pathological aggregation of endogenous Aβ in Alzheimer’s disease (AD). Zinc-induced Aβ oligomerization is mediated by the metal-binding domain (MBD) which includes N-terminal residues 1–16 (Aβ1–16). Earlier, it has been shown that Aβ1–16 as well as some of its naturally occurring variants undergoes zinc-induced homodimerization via the interface in which zinc ion is coordinated by Glu11 and His14 of the interacting subunits. In this study using surface plasmon resonance technique, we have found that in the presence of zinc ions Aβ1–16 forms heterodimers with MBDs of two Aβ species linked to AD: Aβ containing isoAsp7 (isoAβ) and Aβ containing phosphorylated Ser8 (pS8-Aβ). The heterodimers appear to possess the same interface as the homodimers. Simulation of 200 ns molecular dynamic trajectories in two constructed models of dimers ([Aβ1–16/Zn/Aβ1–16] and [isoAβ1–16/Zn/Aβ1–16]), has shown that conformational flexibility of the N-terminal fragments of the dimer subunits is controlled by the structure of corresponding sites 6–8. The data suggest that isoAβ and pS8-Aβ can be involved in the AD pathogenesis by means of their zinc-dependent interactions with endogenous Aβ resulting in the formation of heterodimeric seeds for amyloid aggregation.
Landscape Features in the new CAP (2023-2028)
Creators: name: LAWSON, Gerry
name: De BOECK, Anna
Publisher: name: Zenodo
Year: 2023
Subjects: Agroforestry
Landscape features
Lines of trees
Hedges
DigitAF

description: EURAF and ELO have collated the selection of Landscape Features made by Member States in their Strategic Plans for 2023-2027. All MS except FI and SE implement at least one of the options for hedges, trees in groups, trees in line, isolated trees and Forest margins, but the rules for tree crown size and block size differ considerably, and are often not clearly specified. Agroforestry was one of the Ecological Focus Area options in the previous CAP, although little used by MS. If it is to make a significant contribution to the rural economy and to GHG sequestration before 2030 then greater clarity is needed for farmers that existing managed and pruned lines of trees in silvoarable or pastoral systems will not detract from basic payments (BISS) in the new CAP, and that new agroforestry plantations, made with PIllar I or Pillar II assistance will qualify for continuing BISS payments. EURAF stresses that national IACS/LPIS databases are most appropriate for estimation of the area of Landscape Features, and looks for clarity from MS on the size and density of small tree-blocks which are permitted on farms, without changing their designation from “agricultural” to “forest” land.
description: EURAF Policy Briefing #21
Thermal Stability Study of Pd-composite Membrane Fabricated by Surfactant Induced Electroless Plating (SIEP)
Creators: name: Islam, Syed Z.
name: Vishwanath G. Deshmane
name: Ilias, Shamsuddin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Earth and Environmental Sciences
Cell Biology
Physics
Biochemistry
Biophysics

description: Over the years, several different methods have been developed by modifying the conventional electroless plating (CEP) technique to fabricate dense thin Pd composite membranes with high H2 permselectivity. In this study, Pd composite membranes on macroporous stainless steel substrate (MPSS) were fabricated using CEP and novel surfactant induced electroless plating (SIEP) methods. The structural characteristics of CEP and SIEP fabricated Pd membranes were investigated before and after the heat treatment using SEM, XRD, EDS, and AFM techniques. The H2 permselectivity performance of the SIEP membranes was compared with that of CEP at different temperatures and trans-membrane pressures in the range of 523-823 K and 20-100 psi, respectively. The long-term thermal stability test of SIEP fabricated membranes was carried out on two different membranes, fabricated on MPSS substrates with and without oxide layer at 15 psi transmembrane pressure and thermal cycling of 573-723-573 K. The microstructure analysis revealed that SIEP membranes have finer grains and diffused grain boundaries resulting in uniform, smooth, continuous and pinhole free Pd-film. The SIEP membrane showed eight-fold higher H2 flux (1.7172 mol/m2/s) and four-fold higher H2 selectivity (~148) at 823 K and 100 psi trans-membrane pressure, compared to CEP membrane. Pd/MPSS membrane subjected to test for long-term performance and thermal cycling showed stable performance up to 1200 h while maintaining infinite H2 selectivity. Interestingly, although the thickness of Pd/oxi-MPSS (13.49 µm) membrane was higher than that of Pd/MPSS (11.6 µm) membrane, the H2 flux of Pd/oxi-MPSS membrane was two-times higher than that of Pd/MPSS, attributed to the effective action of oxide layer as diffusion barrier.
Random matrices: Universality of local spectral statistics of non-Hermitian matrices
Creators: name: Tao, Terence
name: Vu, Van
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: It is a result of Ginibre that the normalized bulk $k$-point correlation functions of a complex $n\times n$ Gaussian matrix with independent entries of mean zero and unit variance are asymptotically given by the determinantal point process on $\mathbb{C}$ with kernel $K_{\infty}(z,w):=\frac{1}πe^{-|z|^2/2-|w|^2/2+z\bar{w}}$ in the limit $n\to\infty$. We show that this asymptotic law is universal among all random $n\times n$ matrices $M_n$ whose entries are jointly independent, exponentially decaying, have independent real and imaginary parts and whose moments match that of the complex Gaussian ensemble to fourth order. As an application, we extend a central limit theorem for the number of eigenvalues of complex Gaussian matrices in a small disk to these more general ensembles. These are non-Hermitian analogues of some recent universality results for Hermitian Wigner matrices. However, a new difficulty arises in the non-Hermitian case, due to the instability of the spectrum for such matrices. To resolve this, we work with the log-determinants $\log|\det(M_n-z_0)|$ rather than with the Stieltjes transform $\frac{1}{n}\operatorname {tr}(M_n-z_0)^{-1}$. Our main tools are a four moment theorem for these log-determinants, together with a strong concentration result for the log-determinants in the Gaussian case. The latter is established by studying the solutions of a certain nonlinear stochastic difference equation. With some extra consideration, we can extend our arguments to the real case, proving universality for correlation functions of real matrices which match the real Gaussian ensemble to the fourth order. As an application, we show that a real $n\times n$ matrix whose entries are jointly independent, exponentially decaying and whose moments match the real Gaussian ensemble to fourth order has $\sqrt{\frac{2n}π}+o(\sqrt{n})$ real eigenvalues asymptotically almost surely.
description: Published in at http://dx.doi.org/10.1214/13-AOP876 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org). This version notes an error in Proposition 34, and indicates a workaround so as not to impact the remainder of the paper
Presentations on the history and current activities of the ICSP
Creators: name: Oren, Aharon
name: Ventura, Stefano
name: Göker, Markus
Publisher: name: Zenodo
Year: 2024

description: The presentations collected here on the history or the current activities of the ICSP, or both, have been given at various types of events. They do not constitute official reports on the activities of the ICSP, but have been placed here in the hope of providing easily digestible information about the committee.
Calculating complexity of large randomized libraries
Creators: name: Kong, Yong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Computation (stat.CO)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Randomized libraries are increasingly popular in protein engineering and other biomedical research fields. Statistics of the libraries are useful to guide and evaluate randomized library construction. Previous works only give the mean of the number of unique sequences in the library, and they can only handle equal molar ratio of the four nucleotides at a small number of mutation sites. We derive formulas to calculate the mean and variance of the number of unique sequences in libraries generated by cassette mutagenesis with mixtures of arbitrary nucleotide ratios. Computer program was developed which utilizes arbitrary numerical precision software package to calculate the statistics of large libraries. The statistics of library with mutations in more than $20$ amino acids can be calculated easily. Results show that the nucleotide ratios have significant effects on these statistics. The more skewed the ratio, the larger the library size is needed to obtain the same expected number of unique sequences. The program is freely available at \url{http://graphics.med.yale.edu/cgi-bin/lib_comp.pl}.
description: 14 pages, 4 figures
E-Pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for Chronic Kidney Disease
Creators: name: Selvaraman Nagamani
name: J. John Marshal
name: Karthikeyan Muthusamy
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Meta Science
subject: Chemistry
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Chronic Kidney Disease (CKD) is a prominent health issue reported globally. The level of the vitamin D receptor (VDR) and cytochrome P450 enzyme 24-hydroxylase (CYP24A1) are crucial in the pathogenesis of secondary hyperparathyroidism (sHPT) in CKD. An elevated expression of the CYP24A1 leads to the deficiency of vitamin D and resistance to vitamin D therapy. Hence, VDR agonists and CYP24A1 antagonists are suggested to CKD patients for the management of biochemical complications. CTA-018 is a recently reported analogue and acts as a potent CYP24A1 inhibitor. It inhibits CYP24A1 with an IC50 27 ± 6 nM, about 10 times more potentially than the non-selective inhibitor ketoconazole (253 ± 20 nM), and it is also been reported to induce the VDR expression. Thus, CTA-018 is under clinical trial among CKD patients. In this study, combined molecular docking and pharmacophore filtering were employed to identify compounds better than CTA-018. A huge set of 9127 compounds from Sweet Lead database were docked into the active site of VDR using Glide XP program. E-Pharmacophore was developed from both the targets along with CTA-018. The compounds retrieved from the two different pharmacophore based screening were re-docked into the active site of CYP24A1. The hits that bind well at both the active sites and matched with the pharmacophore models were considered as possible dual functional molecules against VDR and CYP24A1. Further, molecular dynamics simulation and subsequent energy decomposition analyses were also performed to study the role of specific amino acids in the active site of both VDR and CYP24A1.
Bayesian analysis for mixtures of discrete distributions with a non-parametric component
Creators: name: Alhaji, Baba B.
name: Hongsheng Dai
name: Hayashi, Yoshiko
name: Vinciotti, Veronica
name: Harrison, Andrew
name: Lausen, Berthold
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Bayesian finite mixture modelling is a flexible parametric modelling approach for classification and density fitting. Many areas of application require distinguishing a signal from a noise component. In practice, it is often difficult to justify a specific distribution for the signal component; therefore, the signal distribution is usually further modelled via a mixture of distributions. However, modelling the signal as a mixture of distributions is computationally non-trivial due to the difficulties in justifying the exact number of components to be used and due to the label switching problem. This paper proposes the use of a non-parametric distribution to model the signal component. We consider the case of discrete data and show how this new methodology leads to more accurate parameter estimation and smaller false non-discovery rate. Moreover, it does not incur the label switching problem. We show an application of the method to data generated by ChIP-sequencing experiments.
РОЛЬ СОВЕТСКОЙ МИЛИЦИИ В ОСУЩЕСТВЛЕНИИ ПАСПОРТИЗАЦИИ И КОНТРОЛЯ ЗА МИГРАЦИЕЙ НАСЕЛЕНИЯ (1917-1950 ГГ.)
Creators: name: ИСАКОВ ВЛАДИМИР МАРКОВИЧ
Publisher: name: Вестник Московского университета МВД России
Year: 2019
Subjects: МИГРАЦИЯ
ПАСПОРТИЗАЦИЯ
СОВЕТСКАЯ МИЛИЦИЯ
ПЕРЕМЕЩЕНИЕ ГРАЖДАН

description: Рассматриваются вопросы участия советской милиции в паспортизации населения страны и в миграционных процессах до середины 50-х гг. XX в.
Two new Geoplaninae species (Platyhelminthes: Continenticola) from Southern Brazil based on an integrative taxonomic approach
Creators: name: Rossi, Ilana
name: Amaral, Silvana Vargas
name: Giovana Gamino Ribeiro
name: Cauduro, Guilherme Pinto
name: Fick, Israel
name: Valiati, Victor Hugo
name: Leal-Zanchet, Ana Maria
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: 60506 Virology

description: The genera Cratera Carbayo et al., 2013 and Obama Carbayo et al., 2013, belonging to the subfamily Geoplaninae, were recently proposed to encompass some of the species that belonged to the genus Geoplana Stimpson, 1857. Herein we describe two new species of Geoplaninae, occurring in areas of ombrophilous forest which belong to the southern portion of the Brazilian Atlantic Rain Forest. The species are sympatric in their type-locality. In general, both new species herein described match the diagnostic characteristics of their genera. However, some of these features are noteworthy when characters of the new species are taken into consideration, especially the pattern of the sensory pits and the morphology of the prostatic vesicle. Both species are differentiated from their congeners by a combination of morphological characteristics, corroborated by phylogenetic analyses of the cytochrome c oxidase subunit I gene, using maximum likelihood and Bayesian inference, as well as the Automatic Barcode Gap tool.
ЦИФРОВОЕ ПРАВО И ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ В ЭПОХУ ГЛОБАЛИЗАЦИИ: ПРОБЛЕМЫ ТЕОРИИ
Creators: name: ЛЮБАШИЦ ВАЛЕНТИН ЯКОВЛЕВИЧ
name: ОСИНСКИЙ АЛЕКСАНДР СЕРГЕЕВИЧ
Publisher: name: Вестник Московского университета МВД России
Year: 2019
Subjects: ЦИФРОВИЗАЦИЯ
ГОСУДАРСТВО
ПРАВО
ОБЩЕСТВО
СМАРТ-КОНТРАКТ
ИСКУССТВЕННЫЙ ИНТЕЛЛЕКТ
ПРАВОВАЯ ПОЛИТИКА
ПРАВОВАЯ СИСТЕМА
ПРАВОСУДИЕ
ПРАВОПРИМЕНЕНИЕ

description: Рассмотрен ряд юридических аспектов информатизации различных сфер деятельности человека, появления новых и изменения старых институтов государства и общества под натиском всесторонней цифровизации. Катализатором, побуждающим государство говорить с технологиями на языке права, являются опасения за безопасность государства и общества. Новые технологии, наряду с новыми возможностями, по мнению ряда ученых-правоведов, несут в себе и новые угрозы. Поднимается вопрос влияния на безопасность человека массового распространения дронов, беспилотного транспорта, генной инженерии, искусственного интеллекта и т.п.
Two new Geoplaninae species (Platyhelminthes: Continenticola) from Southern Brazil based on an integrative taxonomic approach
Creators: name: Rossi, Ilana
name: Amaral, Silvana Vargas
name: Giovana Gamino Ribeiro
name: Cauduro, Guilherme Pinto
name: Fick, Israel
name: Valiati, Victor Hugo
name: Leal-Zanchet, Ana Maria
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: 60506 Virology

description: The genera Cratera Carbayo et al., 2013 and Obama Carbayo et al., 2013, belonging to the subfamily Geoplaninae, were recently proposed to encompass some of the species that belonged to the genus Geoplana Stimpson, 1857. Herein we describe two new species of Geoplaninae, occurring in areas of ombrophilous forest which belong to the southern portion of the Brazilian Atlantic Rain Forest. The species are sympatric in their type-locality. In general, both new species herein described match the diagnostic characteristics of their genera. However, some of these features are noteworthy when characters of the new species are taken into consideration, especially the pattern of the sensory pits and the morphology of the prostatic vesicle. Both species are differentiated from their congeners by a combination of morphological characteristics, corroborated by phylogenetic analyses of the cytochrome c oxidase subunit I gene, using maximum likelihood and Bayesian inference, as well as the Automatic Barcode Gap tool.
ПРОБЛЕМА ПРИМЕНИМОСТИ РАЗЛИЧНЫХ МЕТОДОЛОГИЧЕСКИХ ПОДХОДОВ К ИССЛЕДОВАНИЮ ДИСЦИПЛИНЫ В ПРАВОВОЙ СФЕРЕ
Creators: name: МАКСАКОВА ЕЛЕНА НИКОЛАЕВНА
name: ХАЛИФАЕВА АНЖЕЛА КУРБАНОВНА
Publisher: name: Вестник Московского университета МВД России
Year: 2019
Subjects: ПРАВОПОНИМАНИЕ
ДИСЦИПЛИНА
ПОЗИТИВИЗМ
ЮРИДИЧЕСКАЯ СОЦИОЛОГИЯ
ФИЛОСОФИЯ ПРАВА
ПЛЮРАЛИЗМ

description: Представлен философско-правовой взгляд на понимание дисциплины в правовой сфере, который позволяет расширить границы исследования данного феномена. Обращается внимание на то, что в советскую эпоху данная проблема изучалась неравномерно, тождественно природе и сущности советского государства. Эпистемологический подход к заявленной в исследовании проблематике требует ее серьезного научного анализа именно с позиции методологического многообразия, которое основывается как раз на двух основных эпистемологических парадигмах метафизической (естественно-правовой) и позитивистской.
К ВОПРОСУ О СТАНОВЛЕНИИ И РАЗВИТИИ ПРОФЕССИОНАЛЬНОЙ ПОДГОТОВКИ СОТРУДНИКОВ РЕГУЛЯРНОЙ ПОЛИЦИИ В РОССИЙСКОЙ ИМПЕРИИ: ИСТОРИКО-ПРАВОВОЙ АСПЕКТ
Creators: name: МИХАЙЛОВА НАТАЛЬЯ ВЛАДИМИРОВНА
name: ГОСТЕВ СЕРГЕЙ СЕРГЕЕВИЧ
Publisher: name: Вестник Московского университета МВД России
Year: 2019
Subjects: ПРОФЕССИОНАЛЬНАЯ ПОДГОТОВЛЕННОСТЬ СОТРУДНИКА ОВД
РЕГУЛЯРНАЯ ПОЛИЦИЯ
РОССИЙСКАЯ ИМПЕРИЯ

description: Рассматривается процесс становления и развития профессиональной подготовки сотрудников регулярной полиции в Российской империи (1718 1800 гг.). Поднимается вопрос о причинах создания регулярной полиции Петром I. Отмечается, что становление и развитие системы профессиональной подготовки имеет длительную историю. И обусловлено это тем, что «профессиональное мастерство» является, фактически, главным требованием, предъявляемым к сотруднику органов внутренних дел. Кроме того, реформирование путей и способов повышения уровня профессиональной подготовки сотрудников МВД всегда актуальное и ориентированое на улучшении качества выполнения служебных обязанностей.
ПОНЯТИЕ «ДЕМОКРАТИЧЕСКИЙ РЕЖИМ» В ТЕОРИИ ГОСУДАРСТВА И ПРАВА И ИСТОРИКО-ПРАВОВЫХ НАУКАХ
Creators: name: НАГАЛИНА МАРИНА ВИКТОРОВНА
Publisher: name: Вестник Московского университета МВД России
Year: 2019
Subjects: ГОСУДАРСТВЕННЫЙ РЕЖИМ
ДЕМОКРАТИЧЕСКИЙ РЕЖИМ
ТЕОРИЯ ГОСУДАРСТВА И ПРАВА
ИСТОРИЯ ГОСУДАРСТВА И ПРАВА
ИСТОРИЯ ПОЛИТИЧЕСКИХ И ПРАВОВЫХ УЧЕНИЙ

description: Уточняются смысл и содержание понятия «демократический режим», которое широко используется в современных теоретико-правовых и историко-правовых исследованиях. Обосновывается, что юридический концепт современного демократического режима формируется теорией государства и права. Вместе с тем, в силу неразрывности связи теоретико-правовых и историко-правовых знаний на содержание названного концепта также влияют результаты обобщения исторического опыта развития права демократических государств, а также изучения различных интерпретаций демократии в истории политико-правовой мысли.
Technical Report: SPIDAL Summer REU 2015: Biomolecular benchmark systems
Creators: name: Kenney, Ian M.
name: Beckstein, Oliver
Publisher: name: figshare
Year: 2015
Subjects: subject: Computational Physics
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Biophysics

description: Analysis of molecular dynamics (MD) trajectories is becoming more and more challenging with simulation times routinely exceeding microseconds (with millions of frames) and increasing in size (with millions of particles). The MDAnalysis library (http://mdanalysis.org) is a versatile open source package that provides a foundation for analysing trajectories, with a particular emphasis on biomolecular simulations. In order to improve MDAnalysis for large simulations, we developed a set of non-trivial benchmarking systems of variable sizes. We generated a modular library of lipid vesicles with the coarse-grained Dry Martini force field, ranging in size from 10 nm to 30 nm radius. These vesicles can be combined in larger multi-vesicle systems in order to produce a range of benchmark systems with variable particle numbers. The systems will also allow us to address the question under which conditions vesicles fuse. We generated simulation systems with up to six vesicles and 3.5 million particles and performed initial simulations on local computing resources. We benchmarked the performance of MDAnalysis to load and process large systems. Our trajectory data set and benchmarking results will be useful to guide future development of MDAnalysis and its integration with the SPIDAL library.

Files suitable for benchmarking large systems are available as https://dx.doi.org/10.6084/m9.figshare.3406708 .