cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Berezin-Toeplitz quantization on Kaehler manifolds
Creators: name: Ma, Xiaonan
name: Marinescu, George
Publisher: name: arXiv
Year: 2010
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: Complex Variables (math.CV)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 53D50, 53C21, 32Q15

description: We study the Berezin-Toeplitz quantization on Kaehler manifolds. We explain first how to compute various associated asymptotic expansions, then we compute explicitly the first terms of the expansion of the kernel of the Berezin-Toeplitz operators, and of the composition of two Berezin-Toeplitz operators. As application we estimate the norm of Donaldson's Q-operator.
description: 45 pages, footnote at page 3 and Remark 0.5 added; v.3 is a final update to agree with the published paper
CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene
Creators: name: Langmann, Thomas
name: Lai, C. C.
name: Weigelt, K.
name: Tam, B. M.
name: Warneke-Wittstock, R.
name: Moritz, O. L.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2008
Subjects: subject: 610 Medizin

description: X-linked juvenile retinoschisis is a heritable condition of the retina in males caused by mutations in the RS1 gene. Still, the cellular function and retina-specific expression of RS1 are poorly understood. To address the latter issue, we characterized the minimal promoter driving expression of RS1 in the retina. Binding site prediction, site-directed mutagenesis, and reporter assays suggest an essential role of two nearby cone-rod homeobox (CRX)-responsive elements (CRE) in the proximal −177/+32 RS1 promoter. Chromatin immunoprecipitation associates the RS1 promoter in vivo with CRX, the coactivators CBP, P300, GCN5 and acetylated histone H3. Transgenic Xenopus laevis expressing a green fluorescent protein (GFP) reporter under the control of RS1 promoter sequences show that the −177/+32 fragment drives GFP expression in photoreceptors and bipolar cells. Mutating either of the two conserved CRX binding sites results in strongly decreased RS1 expression. Despite the presence of sequence motifs in the promoter, NRL and NR2E3 appear not to be essential for RS1 expression. Together, our in vitro and in vivo results indicate that two CRE sites in the minimal RS1 promoter region control retinal RS1 expression and establish CRX as a key factor driving this expression.
Gravitational microlensing as a test of a finite-width disk model of the Galaxy
Creators: name: Sikora, Szymon
name: Bratek, Łukasz
name: Jałocha, Joanna
name: Kutschera, Marek
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The aim of this work is to show, in the framework of a simple finite-width disk model, that the amount of mass seen through gravitational microlensing measurements in the region $0
description: 10 pages, 12 figures
ANOVA kernels and RKHS of zero mean functions for model-based sensitivity analysis
Creators: name: Durrande, Nicolas
name: Ginsbourger, David
name: Roustant, Olivier
name: Carraro, Laurent
Publisher: name: arXiv
Year: 2011
Subjects: subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Given a reproducing kernel Hilbert space H of real-valued functions and a suitable measure mu over the source space D (subset of R), we decompose H as the sum of a subspace of centered functions for mu and its orthogonal in H. This decomposition leads to a special case of ANOVA kernels, for which the functional ANOVA representation of the best predictor can be elegantly derived, either in an interpolation or regularization framework. The proposed kernels appear to be particularly convenient for analyzing the e ffect of each (group of) variable(s) and computing sensitivity indices without recursivity.
A* Orthogonal Matching Pursuit: Best-First Search for Compressed Sensing Signal Recovery
Creators: name: Karahanoglu, Nazim Burak
name: Erdogan, Hakan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Compressed sensing is a developing field aiming at reconstruction of sparse signals acquired in reduced dimensions, which make the recovery process under-determined. The required solution is the one with minimum $\ell_0$ norm due to sparsity, however it is not practical to solve the $\ell_0$ minimization problem. Commonly used techniques include $\ell_1$ minimization, such as Basis Pursuit (BP) and greedy pursuit algorithms such as Orthogonal Matching Pursuit (OMP) and Subspace Pursuit (SP). This manuscript proposes a novel semi-greedy recovery approach, namely A* Orthogonal Matching Pursuit (A*OMP). A*OMP performs A* search to look for the sparsest solution on a tree whose paths grow similar to the Orthogonal Matching Pursuit (OMP) algorithm. Paths on the tree are evaluated according to a cost function, which should compensate for different path lengths. For this purpose, three different auxiliary structures are defined, including novel dynamic ones. A*OMP also incorporates pruning techniques which enable practical applications of the algorithm. Moreover, the adjustable search parameters provide means for a complexity-accuracy trade-off. We demonstrate the reconstruction ability of the proposed scheme on both synthetically generated data and images using Gaussian and Bernoulli observation matrices, where A*OMP yields less reconstruction error and higher exact recovery frequency than BP, OMP and SP. Results also indicate that novel dynamic cost functions provide improved results as compared to a conventional choice.
description: accepted for publication in Digital Signal Processing
Effect of Late-stage Therapy on Disease Progression in AAV-mediated Rescue of Photoreceptor Cells in the Retinoschisin-deficient Mouse
Creators: name: Janssen, A.
name: Min, S. H.
name: Molday, L. .
name: Tanimoto, N.
name: Seeliger, N. W.
name: Hauswirth, W. W.
name: Molday, R. S.
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2008
Subjects: subject: 610 Medizin

description: Proof-of-concept for a successful adeno-associated virus serotype 5 (AAV5)-mediated gene therapy in X-linked juvenile retinoschisis (XLRS) has been demonstrated in an established mouse model for this condition. The initial studies concentrated on early time-points of treatment. In this study, we aimed to explore the consequences of single subretinal injections administered at various stages of more advanced disease. By electroretinogram (ERG), functional improvement in treated versus untreated eyes is found to be significant in retinoschisin-deficient mice injected at the time-points of 15 days (P15), 1 month (PM1), and 2 months (PM2) after birth. In mice treated at 7 months after birth (PM7), an age previously shown to exhibit advanced retinal disease, ERG responses reveal no beneficial effects of vector treatment. Generally, functional rescue is paralleled by sustained retinoschisin expression and significant photoreceptor survival relative to untreated eyes. Quantitative measures of photoreceptors and peanut agglutinin-labeled ribbon synapses demonstrate rescue effects even in mice injected as late as PM7. Taken together, AAV5-mediated gene replacement is beneficial in slowing disease progression in murine XLRS. In addition, we show the effectiveness of rescue efforts even if treatment is delayed until advanced signs of disease have developed. Human XLRS patients might benefit from these findings, which suggest that the effectiveness of treatment appears not to be restricted to the early stages of the disease, and that treatment may prove to be valuable even when administered at more advanced stages.
Entropy and Entropy Production in Some Applications
Creators: name: Zhang, Yong-Jun
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: By using entropy and entropy production, we calculate the steady flux of some phenomena. The method we use is a competition method, $S_S/τ+σ={\it maximum}$, where $S_S$ is system entropy, $σ$ is entropy production and $τ$ is microscopic interaction time. System entropy is calculated from the equilibrium state by studying the flux fluctuations. The phenomena we study include ionic conduction, atomic diffusion, thermal conduction and viscosity of a dilute gas.
title: КОРМОВАЯ ДОБАВКА НА ОСНОВЕ ПИВНОЙ ДРОБИНЫ В КОМБИКОРМАХ  ДЛЯ ЦЫПЛЯТ-БРОЙЛЕРОВ
Creators: name: Юрина, Наталья Александровна
name: Лабутина, Наталия Денисовна
name: Хорин, Борис Владимирович
name: Петенко, Александр Иванович
name: Петенко, Иван Александрович
name: Гнеуш, Анна Николаевна
Publisher: name: ФГБНУ КНЦЗВ
Year: 2021

description: Проблемы истощения ресурсов, продовольственной безопасности и охраны окружающей среды делают акцент на разработке новых продуктов с низкой стоимостью и высоким пищевым функционалом. В результате применения исследуемой биодобавки было установлено повышение живой массы во второй группе птицы на 8,0 %, средне-суточного прироста живой массы - на 8,2 % при снижении затрат корма на единицу продукции на 8,0 %. По результатам анализа микрофлоры содержимого слепых от-ростков кишечника, выявлено снижение в опытной группе птицы общего микробного числа с 2х109 до 3х107 и увеличение количества лактобактерий с 1х106 до 6х107.
Making sense of reality through fiction : approaching memes through the intersecting lenses of cognitive linguistics and narratology
Creators: name: Colautti, Jesse Thomas
Publisher: name: University of British Columbia
Year: 2017

description: In this thesis project, I develop a new approach to examine how and why people use fictive narratives to cope with traumatic events. While this area of research has primarily been studied through the lenses of cognitive narratology and psychology, I adapt a cognitive linguistic methodology, centered on the theoretical framework of conceptual blending, frame metonymy, and viewpoint networks, to analyze multimodal online memes that blend popular fictive narratives with traumatic real-world events. This project differs from past analyses of memes by considering not just the visual and textual data of a meme, but also the contextual frames that shape the way we interact with memes in everyday online discourse—this includes the social media platforms memes they are shared through and the real-world events that prompt their creation. I focus my analysis on a set of multimodal memes created and shared in the twenty-four-hour period after the 2016 U.S. federal election that blend the shocking electoral victory of Donald Trump with images and dialogue taken from the popular The Lord of the Rings film trilogy. I argue that the creation and sharing of these memes across social media platforms in the immediate aftermath of what many considered a traumatic event provides evidence of how people use specific narratives that are salient to their culture, values, and identity to cope with trauma. These narratives inform future behaviour, provide causal and sequential logic, project closure onto an uncertain future, and connect individual experiences and viewpoints to like-minded collectives.
Determinanten der Lebensqualität und Erwerbsfähigkeit nach Lungenversagen — Ein systematisches Review
Creators: name: Dodoo-Schittko, Frank
name: Brandstetter, Susanne
name: Blecha, Sebastian
name: Thomann-Hackner, Kathrin
name: Brandl, Magdalena
name: Knüttel, Helge
name: Bein, Thomas
name: Apfelbacher, Christian J.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: 610 Medizin

description: Hintergrund: Das akute Lungenversagen des Erwachsenen (ARDS, „acute respiratory distress syndrome“) resultiert aus einer pulmonal oder extrapulmonal bedingten Schädigung des Lungenparenchyms. Die Betroffenen leiden oft unter einer eingeschränkten gesundheitsbezogenen Lebensqualität (HRQoL, „health related quality of life“), psychischen und physischen Einschränkungen sowie andauernder Arbeitsunfähigkeit. Methode: Diese systematische Übersichtsarbeit untersucht die Literatur im Hinblick auf Determinanten von HRQoL und des Wiedereintritts in das Berufsleben (RtW, „return to work“). 24 Beobachtungsstudien mit einer statistischen Assoziation zwischen Determinanten und HRQoL oder RtW wurden eingeschlossen. Wegen der hohen Heterogenität der Studien wurde auf eine statistische Aggregation der einzelnen Effektschätzer verzichtet; die Ergebnisse wurden deskriptiv zusammengefasst. Ergebnisse: Insbesondere eine psychopathologische Symptomatik ist mit eingeschränkter Lebensqualität verbunden. Hingegen fanden sich bei vielen versorgungs- und krankheitsbezogenen Determinanten kleine, nichtsignifikante Effekte auf HRQoL und RtW. Die Ein-Sekunden-Kapazität ist durchweg positiv mit der HRQoL assoziiert. Ein durch Sepsis ausgelöstes ARDS scheint im Vergleich zum ARDS anderer Genese ein Risikofaktor für eine verminderte HRQoL zu sein. Hohe Heterogenität zwischen den Studien und ein durchgängig hohes Risiko eines Selektionsbias erschweren eine Evidenzsynthese erheblich. Schlussfolgerung: Die Identifikation von Determinanten eingeschränkter Lebensqualität nach ARDS ist wesentlich für klinisch relevante Interventionsmöglichkeiten. Über verschiedene Studien hinweg wurden größere signifikante Effekte nur dann beobachtet, wenn Determinanten mit engem inhaltlichem Bezug zu den Skalen der HRQoL-Instrumente auch zeitlich zusammen mit der HRQoL gemessen wurden.
description: Die Dokumentation der Literatursuche ist im verknüpften Datensatz enthalten.
Infinitely $p$-divisible points on abelian varieties defined over function fields of characteristic $p>0$
Creators: name: Rössler, Damian
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: Logic (math.LO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11G10

description: In this article we consider some questions raised by F. Benoist, E. Bouscaren and A. Pillay. We prove that infinitely $p$-divisible points on abelian varieties defined over function fields of transcendence degree one over a finite field are necessarily torsion points. We also prove that when the endomorphism ring of the abelian variety is $\mZ$ then there are no infinitely $p$-divisible points of order a power of $p$.
The Māṁcalāpur Grant
Creators: name: RODRIGUES, TENSING CARLOS
Publisher: name: figshare
Year: 2022
Subjects: subject: History
subject: Anthropology
subject: FOS: Sociology
subject: Archaeology
subject: Geography
subject: Sociology

description: The copper plates were in the possession of a brāmhaṇ in Banḍôḍêṃ when Pissurlencar perused them. He mentions that there were three copper plates issued by Mādhav Mantrī in 1391; but he does not list them; he only discusses one of them named Māṁcalāpur plate, concerning Gōaḷī and Mōuḷī villages. [Pissurlencar, 1937 : Um Passo Do Cronista Barros Elucidado à Luz Duma Inscrição Sānscrita, in O Oriente Portuguêz, vol. XXX, no. 18, 36] But Moraes lists them : first, the Mādhavpur plate, granting land for setting up an agrahār at Kōchrē in “the Sawantvadi state’, as a memorial of his rule over the Konkan; second, the Māṁcalāpur plate granting land for setting up an agrahār at Paramrup (Pomburpa ?), named after his mother Mācaṁbikā; and, third, the Cāuḍālpur plate granting land for setting up an agrahār at Tisvāḍī, named after his father Cāuḍā, Cāuḍibhaṭ, Cāuṁḍā or Cāmuṁḍā. [Moraes, 1945 : A Forgotten Chapter in The History of The Konkan, in Bhārat Kaumudi, 451] There is a small error here; it should read : Māṁcalāpur plate granting land for setting up an agrahār at Tisvāḍī, and the Cāuḍālpur plate granting land for setting up an agrahār at Paramrup. [Epigraphia Indica, XXI, 17]
Molecular evolution and functional divergence of the bestrophin protein family
Creators: name: Milenkovic, Vladimir M.
name: Langmann, Thomas
name: Schreiber, Rainer
name: Kunzelmann, Karl
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2008
Subjects: subject: 610 Medizin

description: BACKGROUND: Mutations in human bestrophin 1 are associated with at least three autosomal-dominant macular dystrophies including Best disease, adult onset vitelliform macular dystrophy and autosomal dominant vitreo-retinochoroidopathy. The protein is integral to the membrane and is likely involved in Ca2+-dependent transport of chloride ions across cellular membranes. Bestrophin 1 together with its three homologues forms a phylogenetically highly conserved family of proteins. RESULTS: A bioinformatics study was performed to investigate the phylogenetic relationship among the bestrophin family members and to statistically evaluate sequence conservation and functional divergence. Phylogenetic tree assembly with all available eukaryotic bestrophin sequences suggests gene duplication events in the lineage leading to the vertebrates. A common N-terminal topology which includes four highly conserved transmembrane domains is shared by the members of the four paralogous groups of vertebrate bestrophins and has been constrained by purifying selection. Pairwise comparison shows that altered functional constraints have occurred at specific amino acid positions after phylogenetic diversification of the paralogues. Most notably, significant functional divergence was found between bestrophin 4 and the other family members, as well as between bestrophin 2 and bestrophin 3. Site-specific profiles were established by posterior probability analysis revealing significantly divergent clusters mainly in two hydrophilic loops and a region immediately adjacent to the last predicted transmembrane domain. Strikingly, codons 279 and 347 of human bestrophin 4 reveal high divergence when compared to the paralogous positions strongly indicating the functional importance of these residues for the bestrophin 4 protein. None of the functionally divergent amino acids were found to reside within obvious sequences patterns or motifs. CONCLUSION: Our study highlights the molecular evolution of the bestrophin family of transmembrane proteins and indicates amino acid residues likely relevant for distinct functional properties of the paralogues. These findings may provide a starting point for further experimental verifications.
In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC)
Creators: name: Brandl, Caroline
name: Zimmermann, Stephanie J.
name: Milenkovic, Vladimir M.
name: Rosendahl, S. M.
name: Grassmann, Felix
name: Milenkovic, Andrea
name: Hehr, Ute
name: Federlin, Marianne
name: Wetzel, Christian H.
name: Helbig, Horst
name: Weber, Bernhard H. F.
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Induced pluripotent stem cell; Retinal pigment epithelium; Dermal fibroblast; Bestrophin-1; BEST1
subject: 610 Medizin

description: Induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) has widely been appreciated as a promising tool to model human ocular disease emanating from primary RPE pathology. Here, we describe the successful reprogramming of adult human dermal fibroblasts to iPSCs and their differentiation to pure expandable RPE cells with structural and functional features characteristic for native RPE. Fibroblast cultures were established from skin biopsy material and subsequently reprogrammed following polycistronic lentiviral transduction with OCT4, SOX2, KLF4 and L-Myc. Fibroblast-derived iPSCs showed typical morphology, chromosomal integrity and a distinctive stem cell marker profile. Subsequent differentiation resulted in expandable pigmented hexagonal RPE cells. The cells revealed stable RNA expression of mature RPE markers RPE65, RLBP and BEST1. Immunolabelling verified localisation of BEST1 at the basolateral plasma membrane, and scanning electron microscopy showed typical microvilli at the apical side of iPSC-derived RPE cells. Transepithelial resistance was maintained at high levels during cell culture indicating functional formation of tight junctions. Secretion capacity was demonstrated for VEGF-A. Feeding of porcine photoreceptor outer segments revealed the proper ability of these cells for phagocytosis. IPSC-derived RPE cells largely maintained these properties after cryopreservation. Together, our study underlines that adult dermal fibroblasts can serve as a valuable resource for iPSC-derived RPE with characteristics highly reminiscent of true RPE cells. This will allow its broad application to establish cellular models for RPE-related human diseases.
Distributed Basis Pursuit
Creators: name: Mota, João F. C.
name: Xavier, João M. F.
name: Aguiar, Pedro M. Q.
name: Püschel, Markus
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optimization and Control (math.OC)
subject: Information Theory (cs.IT)
subject: Systems and Control (eess.SY)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We propose a distributed algorithm for solving the optimization problem Basis Pursuit (BP). BP finds the least L1-norm solution of the underdetermined linear system Ax = b and is used, for example, in compressed sensing for reconstruction. Our algorithm solves BP on a distributed platform such as a sensor network, and is designed to minimize the communication between nodes. The algorithm only requires the network to be connected, has no notion of a central processing node, and no node has access to the entire matrix A at any time. We consider two scenarios in which either the columns or the rows of A are distributed among the compute nodes. Our algorithm, named D-ADMM, is a decentralized implementation of the alternating direction method of multipliers. We show through numerical simulation that our algorithm requires considerably less communications between the nodes than the state-of-the-art algorithms.
description: Preprint of the journal version of the paper; IEEE Transactions on Signal Processing, Vol. 60, Issue 4, April, 2012
Flame front propagation IV: Random Noise and Pole-Dynamics in Unstable Front Propagation II
Creators: name: Kupervasser, Oleg
name: Olami, Zeev
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: 37C99

description: The current paper is a corrected version of our previous paper arXiv:adap-org/9608001. Similarly to previous version we investigate the problem of flame propagation. This problem is studied as an example of unstable fronts that wrinkle on many scales. The analytic tool of pole expansion in the complex plane is employed to address the interaction of the unstable growth process with random initial conditions and perturbations. We argue that the effect of random noise is immense and that it can never be neglected in sufficiently large systems. We present simulations that lead to scaling laws for the velocity and acceleration of the front as a function of the system size and the level of noise, and analytic arguments that explain these results in terms of the noisy pole dynamics.This version corrects some very critical errors made in arXiv:adap-org/9608001 and makes more detailed description of excess number of poles in system, number of poles that appear in the system in unit of time, life time of pole. It allows us to understand more correctly dependence of the system parameters on noise than in arXiv:adap-org/9608001
description: 23 pages, 4 figures,revised, version accepted for publication in journal "Combustion, Explosion and Shock Waves". arXiv admin note: substantial text overlap with arXiv:nlin/0302021, arXiv:adap-org/9608001, arXiv:nlin/0302017
Split Course Hyperfractionated Accelerated Radio-Chemotherapy (SCHARC) for patients with advanced head and neck cancer: Influence of protocol deviations and hemoglobin on overall survival, a retrospective analysis
Creators: name: Stadler, Peter
name: Putnik, Kurt
name: Kreimeyer, Thore
name: Sprague, Lisa D.
name: Koelbl, Oliver
name: Schäfer, Christof
Publisher: name: Universität Regensburg
Year: 2006
Subjects: subject: 610 Medizin

description: Background The advantage of hyperfractionated accelerated radiation therapy for advanced head and neck cancer has been reported. Furthermore, randomized trials and meta-analyses have confirmed the survival benefit of additional chemotherapy to radiotherapy. We retrospectively analyzed the efficiency and toxicity of the Regensburg standard therapy protocol "SCHARC" and the overall survival of our patients. Methods From 1997 to 2004, 64 patients suffering from advanced head and neck cancer (88 % stage IV, 12 % stage III) were assigned to receive the SCHARC protocol. Around half of the patients were diagnosed with oro-hypopharynx carcinoma (52 %), one third with tongue and floor of mouth tumors (29 %) and one fifth (19 %) suffered from H & N cancer at other sites. The schedule consisted of one therapy block with 30 Gy in 20 fractions over a two week period with concomitant chemotherapy (d 1–5: 20 mg/m2/d DDP + 750–1000 mg/m2/d 5FU (cont. infusion). This therapy block was repeated after a fortnight break up to a cumulative dose of 60 Gy and followed by a boost up to 70 Gy (69–70.5 Gy). All patients assigned to this scheme were included in the survival evaluation. Results Forty patients (63 %) received both radiation and chemotherapy according to the protocol. The mean follow up was 2.3 years (829 d) and the median follow up was 1.9 years (678 d), respectively. The analysis of survival revealed an estimated 3 year overall survival rate of 57 %. No patient died of complications, 52 patients (80 %) had acute grade 2–3 mucositis, and 33 patients (58 %) suffered from acute grade 3 skin toxicity. Leucopenia was no major problem (mean nadir 3.4 g/nl, no patient < 1.0 g/nl) and the mean hemoglobin value decreased from 13.2 to 10.5 g/dl. Univariate analysis of survival showed a better outcome for patients with a hemoglobin nadir >10.5 g/dl and for patients who completed the protocol. Conclusion The SCHARC protocol was effective in patients diagnosed with advanced head and neck cancer. It led to long-term disease control and survival in about 50 % of the patients with significant but acceptable toxicity. Most patients were not anemic at beginning of therapy. Therefore, we could assess the influence of pre-treatment hemoglobin on survival. However, a low hemoglobin nadir was associated with poor outcome. This result suggests an influence of anemia during therapy on prognosis.
QGreenland & CryoCloud:  An open GIS collaboration for education and research
Creators: name: Fisher, Matt
name: Moon, Twila
name: Thurber, Alyse
name: Snow, Tasha
name: Stafford, Trey
Publisher: name: Zenodo
Year: 2023
Subjects: education
cloud
open science
GIS
QGIS
Greenland
QGreenland
CryoCloud
agu
agu2023
agu23

description: A presentation at AGU2023: https://agu.confex.com/agu/fm23/meetingapp.cgi/Paper/1365725
description: Please cite this software using these metadata.
Predictors of poor conditions in the home
Creators: name: Luu, Tram Van Giang May
Publisher: name: University of British Columbia
Year: 2017

description: Despite popular media portraying hoarding to be a problem of extremely poor housekeeping, most hoarded homes are relatively clean – large amounts of stuff just prevent the home from being functional. Some hoarded homes, however, develop poor living conditions like filth or disrepair. To date, little is known about how homes end up this way. The current study identified unique predictors and generated ideas about complex processes involved in the development of poor living conditions in hoarding. Three community agencies shared in-home assessment data for mainly involuntary clients with problematic living conditions, such as hoarded or filthy homes. These community agencies were the Metropolitan Boston Housing Partnership (n=115) in Boston, MA, the Hoarding Action Response Team (n=137) in Vancouver, BC, and the Hamilton Gatekeepers Program (n=209) in Hamilton, ON. Each site completed in-home assessments from 2010-2014 to evaluate client characteristics (lack of insight, social isolation, state of mind) and conditions of the home (number of pets, clutter accumulation, unusable bathrooms or kitchens) using the HOMES: Multidisciplinary Hoarding Risk Assessment, the Clutter Image Rating Scale, or a similar measure. Site-specific regression analyses identified unique predictors of poor living conditions. Clients with high clutter accumulation were at increased risk for squalor at all three sites, while kitchen or bathroom problems uniquely predicted squalor at two sites. Within two agencies, number of pets was also a consistent predictor of one indicator of squalor, the presence of urine or feces. Few clients had household disrepair (9-12% within sites), but findings hint that disrepair is associated with high clutter accumulation. Findings related to poor insight being a predictor of squalor were mixed. This is the first study to directly examine poor living conditions in hoarding. Replicated study findings across sites suggest that common features of hoarding, such as clutter accumulation and unusable rooms, are unique predictors for squalor. Results from this study can help community agencies that deal with problematic living situations prioritize intervention goals, especially if staff believe clients are at risk for poor living conditions.
The verification by demonstration of divine revelation
Creators: name: Dowson, Martin
Publisher: name: Macquarie University
Year: 2023
Subjects: Other education not elsewhere classified

description: Christians claim that the religious propositions to which they hold are not of their own making. Rather, these propositions are alleged to be revealed by God. In this thesis, I examine three methods by which Christians seek to demonstrate, and thus verify, that propositions they allege to be revealed are revealed: observation of, and deduction and induction from, the Bible. These methods are standard within the broader method of theology. While affirming that observation and deduction are appropriate methods for demonstration, I nevertheless show that induction fails to demonstrate that propositions are revealed. Various attempts to rescue induction (i.e., faith, authority, tradition and theology) for the purposes of verification are explored in the thesis. However, I show that each of these attempts also fail for various reasons. In particular, the use of abduction under the auspices of theology fails to rescue induction because of particular limitations in abduction itself. Given the failure of induction to demonstrate that propositions are revealed, and given that many of Christianity’s core propositions (e.g., Jesus is God, Jesus died as a penal substitute for sins, and hell will be populated for eternity) can only be demonstrated to be revealed by induction, I conclude that these propositions cannot be verified to be revealed. Further, I argue that if these propositions cannot be verified by demonstration to be revealed, they are not revealed in the sense that Christians typically take divine revelation i.e., as public revelation. I conclude the analytical component of the thesis by suggesting that a reasonable person, open to the possibility of divine revelation, can nevertheless judge that not all propositions claimed by Christians to be divinely revealed are, in fact, divinely revealed. Consistent with this judgement, in the final chapter of this thesis I explore some implications and applications that arise when Christians over-estimate the size and scope of the corpus of divinely revealed propositions. In this final chapter, I indicate that Christianity may find itself considerably less burdened theologically, ecclesiastically and apologetically if it was to hold less tightly to propositions not demonstrably revealed.
Polyhedral graph abstractions and an approach to the Linear Hirsch Conjecture
Creators: name: Kim, Edward D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 05C12, 52B05, 52B40, 90C05

description: We introduce a new combinatorial abstraction for the graphs of polyhedra. The new abstraction is a flexible framework defined by combinatorial properties, with each collection of properties taken providing a variant for studying the diameters of polyhedral graphs. One particular variant has a diameter which satisfies the best known upper bound on the diameters of polyhedra. Another variant has superlinear asymptotic diameter, and together with some combinatorial operations, gives a concrete approach for disproving the Linear Hirsch Conjecture.
description: 16 pages, 4 figures
Mandibular prognathism caused by acromegaly – a surgical orthodontic case
Creators: name: Gosau, Martin
name: Vogel, Corinna
name: Moralis, Antonios
name: Proff, Peter
name: Kleinheinz, Johannes
name: Driemel, Oliver
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 610 Medizin

description: A 22-year-old man presented for orthodontic surgery because of mandibular prognathism. Clinical symptoms suggested acromegaly, and diagnosis was verified by an endocrinologist as well as by radiograph. Bilateral mandibular prognathism often represents the first and most striking physical characteristic of acromegaly; usually, it is also the main reason why patients seek help from orthodontists or maxillo-facial surgeons. This case report recapitulates the clinical and histopathological findings in pituitary growth hormone (GH) adenomas and emphasises their importance in surgical orthodontic planning. Mandibular prognatism, macroglossia and abnormal growth of hands and feet represent strong indicators for the diagnosis of acromegaly. This disease and its complications not only affect the entire body but increase mortality if the pituitary gland tumour remains untreated.
Generalized Geologic Map for Land-Use Planning: Bell County, Kentucky
Creators: name: Carey, Daniel I.
Publisher: name: Kentucky Geological Survey, University of Kentucky
Year: 2007

description: Abstract:
This map is not intended to be used for selecting individual sites. Its purpose is to inform land-use planners, government officials, and the public in a general way about geologic bedrock conditions that affect the selection of sites for various purposes. The properties of thick soils may supercede those of the underlying bedrock and should be considered on a site-to-site basis. At any site, it is important to understand the characteristics of both the soils and the underlying rock.
Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma
Creators: name: Ettl, Tobias
name: Kleinheinz, Johannes
name: Mehrotra, Ravi
name: Reichert, Torsten E.
name: Schwarz, Stephan
name: Driemel, Oliver
Publisher: name: Universität Regensburg
Year: 2008
Subjects: subject: 610 Medizin

description: Background A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis. Diagnosis is often delayed due to its variable and often benign clinical appearance. Case presentation This case presents a 64-year-old man with a six-month-history of a recurrent diffuse and erythematous painless swelling below the left eye. Several resections with intraoperatively negative resection margins followed, but positive margins were repeatedly detected later on permanent sections. Histopathologic examination of the specimen diagnosed a cutaneous angiosarcoma. Neither, finally achieved negative margins on permanent sections, nor a following chemotherapy could prevent the recurrence of the disease after five months and the patient's dead 21 months after the first diagnosis. Conclusion The case elucidates the current diagnostic and therapeutic dilemma of this entity, which shows an unfavourable clinical course in spite of multimodal therapy.
Multiple M0-brane system in an arbitrary eleven dimensional supergravity background
Creators: name: Bandos, Igor A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The equations of motion of multiple M0{brane (multiple M-wave or mM0) system in an arbitrary D = 11 supergravity superspace, which generalize the Matrix model equations for the case of inter- action with a generic 11D supergravity background, are obtained in the frame of superembedding approach. We also derive the BPS equations for supersymmetric bosonic solutions of these mM0 equations and show that the set of 1/2 BPS solutions contain a fuzzy sphere modeling M2 brane as well as that the Nahm equation appears as a particular case of the 1/4 BPS equations.
description: RevTeX4, 20 pages, no figures. V2: misprints corrected, minor changes, published in Phys. Rev. D82, 105030 (2010)). V3. Dec. 2011 : misprints in coeffs of Eqs.(5.10) corrected
Disease-associated missense mutations in bestrophin-1 affect cellular trafficking and anion conductance
Creators: name: Milenkovic, Vladimir M.
name: Röhrl, Elena
name: Weber, Bernhard H. F.
name: Strauss, Olaf
Publisher: name: Universität Regensburg
Year: 2011
Subjects: subject: 610 Medizin

description: Bestrophin-1, an integral membrane protein encoded by the BEST1 gene, is localized predominantly to the basolateral membrane of the retinal pigment epithelium. Mutations in the BEST1 gene have been associated with Best vitelliforme macular dystrophy (BMD), a central retinopathy with autosomal dominant inheritance and variable penetrance. Over 120 disease-causing mutations are known, the majority of which result in amino acid substitutions within four mutational hot-spot regions in the highly conserved N-terminal half of the protein. Although initially thought to impair Cl⁻ channel function, the molecular pathology of BEST1 mutations is still controversial. We have analyzed the subcellular localization of 13 disease-associated BEST1 mutant proteins in polarized MDCK II cells, an established model of apical to basolateral protein sorting. Immunostaining demonstrated that nine of the 13 mutant proteins failed to integrate into the cell membrane. The defective proteins were predominantly retained in the cytoplasm, whereas wild-type bestrophin-1 revealed cell membrane localization. Functional analysis of I⁻ fluxes in HEK-293 cells showed that all mutants exhibited a significant reduction in anion conductance. Our data indicate that defective intracellular trafficking could be a common cause of BMD accompanied by impaired anion conductance, representing a loss of anion channel function that is probably due to mistargeting of mutant protein.
Quantized Black Hole and Heun function
Creators: name: Momeni, D.
name: Yerzhanov, Koblandy
name: Myrzakulov, Ratbay
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Physics (physics.gen-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Following the simple proposal by He and Ma for quantization of a black hole(BH) by Bohr's idea about the atoms, we discussed the solvability of the wave equation for such a BH. We superficial solved the associated Schrodinger equation. The eigenfunction problem reduces to HeunB $H$ differential equation which is a natural generalization of the hypergeometric differential equation. In other words, the spectrum can be determined by solving the Heun's differential equation.
description: 9 pages,Title Changed, 3 figures, Refrences added
Evaluation of a new arterial pressure-based cardiac output device requiring no external calibration
Creators: name: Prasser, Christopher
name: Bele, Sylvia
name: Keyl, Cornelius
name: Schweiger, Stefan
name: Trabold, Benedikt
name: Amann, Matthias
name: Welnhofer, Julia
name: Wiesenack, Christoph
Publisher: name: Universität Regensburg
Year: 2007
Subjects: subject: 610 Medizin

description: Background Several techniques have been discussed as alternatives to the intermittent bolus thermodilution cardiac output (COPAC) measurement by the pulmonary artery catheter (PAC). However, these techniques usually require a central venous line, an additional catheter, or a special calibration procedure. A new arterial pressure-based cardiac output (COAP) device (FloTrac™, Vigileo™; Edwards Lifesciences, Irvine, CA, USA) only requires access to the radial or femoral artery using a standard arterial catheter and does not need an external calibration. We validated this technique in critically ill patients in the intensive care unit (ICU) using COPAC as the method of reference. Methods We studied 20 critically ill patients, aged 16 to 74 years (mean, 55.5 ± 18.8 years), who required both arterial and pulmonary artery pressure monitoring. COPAC measurements were performed at least every 4 hours and calculated as the average of 3 measurements, while COAP values were taken immediately at the end of bolus determinations. Accuracy of measurements was assessed by calculating the bias and limits of agreement using the method described by Bland and Altman. Results A total of 164 coupled measurements were obtained. Absolute values of COPAC ranged from 2.80 to 10.80 l/min (mean 5.93 ± 1.55 l/min). The bias and limits of agreement between COPAC and COAP for unequal numbers of replicates was 0.02 ± 2.92 l/min. The percentage error between COPAC and COAP was 49.3%. The bias between percentage changes in COPAC (ΔCOPAC) and percentage changes in COAP (ΔCOAP) for consecutive measurements was -0.70% ± 32.28%. COPAC and COAP showed a Pearson correlation coefficient of 0.58 (p < 0.01), while the correlation coefficient between ΔCOPAC and ΔCOAP was 0.46 (p < 0.01). Conclusion Although the COAP algorithm shows a minimal bias with COPAC over a wide range of values in an inhomogeneous group of critically ill patients, the scattering of the data remains relative wide. Therefore, the used algorithm (V 1.03) failed to demonstrate an acceptable accuracy in comparison to the clinical standard of cardiac output determination.
Geographic peculiarities of structure and hemicloning reproduction of Pelophylax esculentus water frog complex (Anura, Ranidae) populations in the East European Plain within Ukraine
Creators: name: Mezhzherin, Sergey
name: Morozov-Leonov, Svyatoslav
name: Nekrasova, Oksana
name: Rostovskaya, Olga
Publisher: name: Brill Online
Year: 2023
Subjects: Ecology not elsewhere classified

description: Geographic peculiarities of population structure and hemicloning reproduction of the water frog Pelophylax esculentus complex of 904 samples within southern East European Plain were analyzed. The proportion of populations of P. ridibundus is 0.667 against those 0.042 of P. lessonae. The RE-type populations are the most common among mixed ones (0.153). The colonies of the two parental species and P. kl. esculentus (REL-type), as well as those of P. lessonae with P. kl. esculentus (LE-type), have the frequencies 0.072 and 0.046, respectively. All-hybrid populations (E-type) are not numerous across the region (0.017). In the populations of Central, Northern and Western Ukraine, the P. lessonae genome is eliminated during gametogenesis within hybrids while in the Lower Dnieper and Lower Danube drainages, genome of P. ridibundus is eliminated. In the Eastern Ukraine populations, hybrids usually produce diploid gametes or haploid gametes with the P. ridibundus genome, less often with the chromosome set of P. lessonae only, and even more rarely a mixture of different types of gametes. The predominance of P. ridibundus in hybrid communities and the elimination of the P. lessonae genome in hybrids inevitably leads to the transformation of hybrid populations into “pure” R-type populations. This circumstance makes hybridization with P. ridibundus a factor in the shrinking of P. lessonae populations. That trend is especially expressed in the Forest steppe zone, where hybridization proceeds most intensively, the P. lessonae genome is eliminated in hybrids, and unstable populations with a numerical superiority of P. ridibundus predominate.
Brauer-Manin pairing, class field theory and motivic homology
Creators: name: Yamazaki, Takao
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 11S25, 14G20, 14C25

description: For a smooth proper variety over a $p$-adic field, the Brauer group and abelian fundamental group are related to the higher Chow groups by the Brauer-Manin pairing and the class field theory. We generalize this relation to smooth (possibly non-proper) varieties, using the motivic homology and the tame version of Wiesend's ideal class group. Several examples are discussed.
description: 25 pages
Efficient synthesis of novel imidazo[1,2-a]pyrimidine derivatives via one-pot three-component procedure
Creators: name: Mommahed Heravi, Majid
name: Sadjadi, Samaheh
name: Nahavandi, Fatemeh
Publisher: name: figshare
Year: 2022
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30701 Quantum Chemistry
subject: 39904 Organometallic Chemistry
subject: Organic Chemistry
subject: 30502 Natural Products Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30504 Organic Green Chemistry
subject: 30303 Optical Properties of Materials

description: Synthesis of novel derivatives of imidazo[1,2-a]pyrimidine from one-pot three-component reaction of aldehydes, 2-amino-benzimidazole, and α-tetralone in the presence of catalytic amount of p-toluene sulfonic acid under reflux condition in EtOH has been presented. The simplicity and safety of the process, high yields and short reaction times were the main advantages of this protocol.
Agonistic behaviour in mormyrid fish: Latency-relationship between the electric discharges of Gnathonemus petersii and Mormyrus rume
Creators: name: Bauer, Richard
name: Kramer, Bernd
Publisher: name: Universität Regensburg
Year: 1974
Subjects: subject: 590 Tiere (Zoologie)

description: Während des agonistischen Verhaltens beantwortet G. petersii elektrische Organentladungen eines M. rume statistisch bevorzugt nach einer Latenzzeit von nur ca. 11 msec. Dies deutet auf die Existenz einer besonders raschen Reflexbahn hin, deren spezifische Aufgabe offenbar die Wahrnehmung und Beantwortung elektrischer Fremdsignale ist.