cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Activation of DDAH for the Treatment of Atherosclerosis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Atherosclerosis (plaque deposition in arteries) is characterized by the build-up of fatty materials such as cholesterol on the walls of blood vessels (arteries) resulting in inflammation and arterial stiffness. Atherosclerosis is a global burden affecting tens of millions of people of all ages. Research has shown that hardening, narrowing and blockage of blood vessels can significantly reduce blood flow and oxygen supply to vital organs of the body and lead to heart attack, stroke, and death. The risk of atherosclerosis is significantly elevated with age, obesity, family history, high blood sugar and lifestyle such as the consumption of high fat diet, lack of exercise and smoking. In particular, tobacco-smoke accelerates plaque deposition in large blood vessels that feed the leg, the brain and the heart increasing the risk of amputation (gangrene), stroke and heart attack in active smokers and these who are exposed to tobacco-smoke through secondhand smoke. According to the American Heart Association (AHA), cigarette smoke is responsible for 440,000 deaths every year in the United States alone and atherosclerosis is one of the principal causes of the deaths that are associated with smoking. In addition, cigarette smoke also increases blood pressure (hypertension) linking the overall increased risk of stroke, heart attack and premature death in smokers who have these conditions compared to non-smokers with high blood pressure. Unfortunately, the existing treatments are less efficient in some patients in lowering fatty deposits or protecting the lining of the blood vessels from being inflamed, hardened or ruptured. Accordingly, there is an urgent need to develop new therapeutic approaches for atherosclerosis.As mentioned above, one of the causes of atherosclerosis and hypertension is inadequate blood flow that is associated with low levels of a molecule called nitric oxide (NO). NO is produced in different parts of the body and is responsible for maintaining blood pressure and the health of the heart and blood vessels. An inhibitor of NO synthesis, known as asymmetric dimethylarginine (ADMA), when present in the body at abnormal levels, is associated with atherosclerosis and hypertension. Therefore, our goal is to discover new drugs that reduce ADMA levels in the body by increasing the action of an enzyme that breaks down ADMA. This enzyme is known as dimethylarginine dimethylaminohydrolase (DDAH). It has already been shown in animals that increasing the action of DDAH have beneficial effects in reducing plaque deposits in atherosclerosis and maintaining blood pressure. We now aim to discover a drug that can be used to treat patients with atherosclerosis and high blood pressure.
Micraspis vittipennis Fauvel
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Micraspis
Micraspis vittipennis

description: Micraspis vittipennis (Fauvel)
Coelophora vittipennis Fauvel, 1903: 328. Micraspis vittipennis: Chazeau 1978: 68.
To date, this species is only known from a single type specimen (female), with no precise locality (see Chazeau 1978). Fauvel (1903) underlined differences with M. lineola, but the lack of male specimen precludes identification of its relationships with M. vittipennis, M. frenata and the four other Micraspis recorded from Australia. We consider this species still as a valid endemic one.
Material examined. NEW CALEDONIA: no precise locality (ONNC).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 309, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Acipenser Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Acipenseridae
Acipenser

description: 118.ACIPENSER.
Spiracula lateralia solitarıa, linearıa.
Os sub capite, retractile, edentulum. Cirri sub rostro, ante os.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 237, DOI: 10.5281/zenodo.14648402
Liolaemus gracilis
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus gracilis

description: Liolaemus gracilis (Bell)
Proctotretus gracilis Bell 1843: 4 (type locality: Puerto Deseado, Santa Cruz Province, Argentina); Duméril & Duméril 1851: 73; Duméril 1856: 542.
Liodera gracilis Gray 1845: 211.
Liolaemus (Ptychodeira) gracilis Girard 1858b: 341.
Liolaemus gracilis Boulenger 1885a: 145; Gallardo 1966: 22; Donoso-Barros 1970a: 183; Blair et al. 1976: 4; Cei & Roig 1976: 69; Gallardo 1977; Cei 1986: 255, 1993: 287; Vanzolini 1986: 14; Laurent 1992: 31; Martori & Aun 1994: 97; Videla & Puig 1994: 99; Etheridge 1995: 33; Avila et al. 1998: 11; Etheridge & Espinoza 2000: 6; Lobo 2001: 139; Pincheira-Donoso 2004b: 13; Chebez et al. 2005: 31; Scolaro 2005: 38; Sura 2005: 429; Díaz & Lobo 2006: 264.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 24, DOI: 10.5281/zenodo.6789337
Chespiritos extendido Kuwahara & Marshall 2020
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sphaeroceridae
Chespiritos
Chespiritos extendido

description: extendido Kuwahara & Marshall
Chespiritos extendido Kuwahara & Marshall, 2020: 184.
Distribution. Cryptogenic. Nearctic, Neotropical; Galápagos: Santa Cruz.
Remarks. Adults of this species were collected in Miconia and Scalesia areas (Kuwahara & Marshall 2020).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 51, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Minotetrastichus frontalis
Creators: name: Kosheleva, O. V.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Minotetrastichus
Minotetrastichus frontalis

description: Minotetrastichus frontalis (Nees, 1834)
Figs 1–7
MATERIAL EXAMINED. Russia. Amur Prov.: KhR, 7 km SE Uril, Dyrovatka River, forest, 6–7.VIII 2022, 1♀ (OK).
DISTRIBUTION. Russia: Nizhegorodskaya, Moscow and Ulyanovsk Provinces, Stavropol Territory, Crimea Republic, Ural, Altai Territory, Novosibisk Province, * Amur Province, Khabarovsk and Primorskiy Territories. Europe, Pakistan, United Arab Emirates, and North America.
HOSTS. Parasitoid of many species of leaf-mining Lepidoptera (especially Phyllonorycter spp.), Coleoptera (Rhynchaenus spp.), and Hymenoptera (Tenthredinidae), as gregarious ectoparasite of their larvae; sometimes as a facultative secondary or tertiary parasite of Braconidae and Chalcidoidea.
REMARKS. The Amurian specimen differs from the European ones in having a pedicel relatively shorter, flagellum with sparser and shorter longitudinal sensilla (Figs 4–6); mid lobe of mesoscutum with one row of 3 adnotaular setae on each side (Fig. 7) [European specimens often have 3–4 or more adnotaular setae with a second row of 1–2 setae (Graham, 1987: P. 52–53)]. Also, the Amurian specimen is similar in colour to the European specimens (a very variable in colour), but differs from the later in having the posterior tergites of the gaster yellow, and the third, fourth and fifth tergites with blackish bands (Figs 1–2).
description: Published as part of Kosheleva, O. V., 2025, EULOPHID WASPS OF THE SUBFAMILY TETRASTICHINAE (HYMENOPTERA, CHALCIDOIDEA) FROM THE KHINGAN RESERVE (AMUR PROVINCE, RUSSIA), WITH DESCRIPTIONS OF NEW SPECIES OF THE GENUS APROSTOCETUS (SUBGENUS OOTETRASTICHUS), pp. 1-15 in Far Eastern Entomologist 515 on page 5, DOI: 10.25221/fee.515.1, http://zenodo.org/record/14659044
Acipenser sturio Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Acipenseridae
Acipenser
Acipenser sturio

description: Sturio.
1. A. cirris 4, squamis dorsalibus 11. Mus. Ad. Fr. 1. p. 54. t. 18. f. 2.
It. Scan. 187. Acipenser.
Art. gen. 65. syn. 91. Acipenser corpore tuberculis spinosis aspero.
Fn. fvec. 27. Acipenser idem.
Gron. mus 2. p. 42. Acipenser idem.
Habitat in mari Europaeo.
Pinnae D. 31. P 30. V 19. A. 24. C. 24.
Severi imp. avo a coronatis mini stris praecunte tibicine ad epulas ad s portabatur.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 237, DOI: 10.5281/zenodo.14648402
Additional file 1: of POWERS
                        forID: Personalized Online Weight and Exercise Response System for Individuals with Intellectual Disability: study protocol for a randomized controlled trial
Creators: name: Neumeier, William
name: Guerra, Nichole
name: Mohanraj Thirumalai
name: Geer, Betty
name: Ervin, David
name: Rimmer, James
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Mental Health

description: Screenshot and description of the POWERS forID homepage. (DOCX 98 kb)
Aprostocetus (Ootetrastichus) mycerinus
Creators: name: Kosheleva, O. V.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Eulophidae
Aprostocetus
Aprostocetus mycerinus

description: Aprostocetus (Ootetrastichus) mycerinus (Walker, 1839)
MATERIAL EXAMINED. Russia. Amur Prov.: KhR, 3 km E Uril, Tarmanchukan River, 3–4.VIII.2022, 8♀ (OK); 7 km SE Uril, Dyrovatka River, 7–8.VIII 2022, 1♀ (OK); 24 km W Arkhara, cordon Kleshinskoe ozero, forest, meadow, 12– 14.VIII 2022, 15♀ (ChV, DK, OK); cordon Juzhnyi, meadow, 13.VIII.2022, 3♀ (OK).
DISTRIBUTION. Russia: Moscow Province, Stavropol Territory, * Amur Province, Primorskiy Territory. Europe, China.
HOSTS. Unknown.The parasitoid associated with Salix spp.
REMARKS. The Amurian specimens is similar to the European specimens, as in redescription by Graham (1987), but differs in having a shorter clava, 3.20–3.43 times as long as broad [4.0–5.5 times as long as broad in European specimens (Graham, 1987: 103)] and fore wing usually longer, up to 2.42 times as long as broad [2.05–2.20 times as long as broad in European specimens [(Graham, 1987: 96, Fig. 121)], legs with fore coxae yellowish [testaceous in European specimens, see ibid], gaster, including ovipositor sheaths, slightly longer, 1.48–1.67 times as long as broad [1.3–1.5 times as long as broad in European specimens, see ibid].
description: Published as part of Kosheleva, O. V., 2025, EULOPHID WASPS OF THE SUBFAMILY TETRASTICHINAE (HYMENOPTERA, CHALCIDOIDEA) FROM THE KHINGAN RESERVE (AMUR PROVINCE, RUSSIA), WITH DESCRIPTIONS OF NEW SPECIES OF THE GENUS APROSTOCETUS (SUBGENUS OOTETRASTICHUS), pp. 1-15 in Far Eastern Entomologist 515 on page 7, DOI: 10.25221/fee.515.1, http://zenodo.org/record/14659044
Cigarette smoke and lung injury: mechanism of nSMase2 action
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoke (CS) contains abundant free radical species and reactive oxidants, which have been suggested to play a role in CS-induced adverse health effects in the lungs. Although the connection between smoking and lung disease is clear, the mechanism by which CS leads to lung injury is poorly understood. It has been proposed that absorption of CS-oxidants, such as hydrogen peroxide (H2O2), by lung epithelial cells may have direct consequences on cell function.Consistently, it was recently demonstrated in our laboratory that the neutral sphingomyelinase2 (nSMase2) is involved in the regulation of cell death, i.e. apoptosis, of lung epithelial cells under CS exposure. The ability of activated nSMase2 in inducing apoptosis is due to the fact that it hydrolyzes the membrane sphingolipid sphingomyelin to ceramide and phosphorylcholine; ceramide, in turn, is working as a molecule that triggers apoptosis. Briefly, reactive CS-oxidants affect nSMase2 function. This results in over-activation of the enzyme, thus over accumulation of ceramide and cell death, thereby leading to lung epithelial injury.Therefore, we will characterize the molecular mechanisms that link CS-oxidants and activation of nSMase2. Our current hypothesis is that CS affects nSMase2 function by modulating its phosphorylation pattern. We will also investigate the effects of CS on nSMase2 expression in cells and in animal models.Characterization of the pathways involved in lung injury at the molecular and cellular level is crucial not only in understanding how CS leads to lung disease, but also in identifying specific targets for the development of therapeutic and pharmacological strategies to block the deleterious effects of CS-oxidants. These therapies would bring benefits to those who still smoke despite the knowledge of health risks as well as those affected by secondhand smoke.
Lepidosina inaequalis
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sphaeroceridae
Lepidosina
Lepidosina inaequalis

description: inaequalis (Malloch)
Leptocera inaequalis Malloch, 1914: 21.
inaequalis: Roháček et al. 2001: 289 [catalogue] (unplaced to genus).
Lepidosina inaequalis: Marshall et al. 2007: 589 [revision].
Distribution. Cryptogenic. Neotropical; Galápagos: San Cristóbal, Santa Cruz.
Remarks. This record was initially based on a single female specimen and was tentatively identified as L. inaequalis (Marshall et al. 2007). Recent rearing studies have produced additional specimens and the initial identification of this species has been confirmed. This species was reared from mud collected fresh from a tortoise wallow in the agricultural zone (Reserva Pájaro Brujo) on Santa Cruz (Lehnen et al. unpubl.).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 52, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Acipenser ruthenus Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Acipenseridae
Acipenser
Acipenser ruthenus

description: ruthenus.
2. A. cirris 4, squamis dorsalibus 15. Mus. Ad. Fr. 1.
p. 54. t. 27. f._2. ê* t. 28_. Fn. svec. 272. Acıpenser ordinibus1.
.
s
5 squamarum ossearum intermedio ossiculis 15.
Habitat in Rutheno; introductus a Rege Friderico I in Malerum Svecia.
Ova hujus & Husonis pro Garo Cavear dicto.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on pages 237-238, DOI: 10.5281/zenodo.14648402
Additional file 1: of POWERS
                        forID: Personalized Online Weight and Exercise Response System for Individuals with Intellectual Disability: study protocol for a randomized controlled trial
Creators: name: Neumeier, William
name: Guerra, Nichole
name: Mohanraj Thirumalai
name: Geer, Betty
name: Ervin, David
name: Rimmer, James
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Screenshot and description of the POWERS forID homepage. (DOCX 98 kb)
title: Zwischen Raum
Creators: name: Kutscher, Tamina;
name: Zimmermann, Lucia
Publisher: name: Fachinformationsdienst Slavistik
Year: 2008
Subjects: subject: Madžirov, Nikola
subject: Mazedonisch
subject: Schriftsteller
subject: Interview
subject: 491.8

description: Der mazedonische Schriftsteller Nikola Madžirov setzt seine Verse zwischen verblasste Aufkleber und angebissene Äpfel, neben Zitate und Erinnerungen, über Bibelstellen und Tao – zwischen Zeilen der Weltliteratur und die Prosaik des Alltags. Er weiss, dass alles schon gesagt wurde. Trotzdem will er mit seiner Poesie neue Räume schaffen.
description: novinkizurückgefragt
Gene-modified Stromal Cell Therapy for Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer-related deaths in the United States. Lung cancer accounted for a total of 159,390 estimated deaths in 2009 in the United States. Approximately, 219,440 new cases occur every year in the United States and worldwide, more than 1.1 million people die from lung cancer annually. Epidemiological studies have shown that there is a strong correlation between tobacco smoking and lung cancer. Approximately 80-85% of all lung cancers occur in the current or former cigarette smokers. At present in the United Stated, there are currently fifty million smokers and fifty million former smokers. Hence, approximately one third of US population is at high risk of developing lung cancer. Surgery, chemotherapy and multimodal treatments are currently available for the treatment of lung cancer; however, 50% of patients experience cancer recurrence after surgery and less than 25% respond to chemotherapy. Despite improvements in the detection and treatment of lung cancer in the past two decades, the long term survival for lung cancer patients remains low with only 15% surviving for 5 years following diagnosis and no patients are being completely cured. Therefore, new approaches for the treatment of lung cancer are urgently needed. One such approach would be to develop immune therapy for lung cancer. Strategies that activate the immune system to react against tumors can be integrated with existing forms of therapy for optimal responses toward this devastating disease. In this proposal we will study how genetically engineered stromal cells expressing a protein CCL21 activate the immune cells of our body to fight lung cancer. We will also study the effect of this therapy on cells that impair our immune system to fight lung cancer. We will use the findings from this study to improve the therapy by using combined approaches that will target the cells that impair this therapy.
Additional file 2: Table S2. of Proteomic analysis of trochophore and veliger larvae development in the small abalone Haliotis diversicolor
Creators: name: Guilan Di
name: Xianghui Kong
name: Xiulian Miao
name: Yifang Zhang
name: Miaoqin Huang
name: Yuting Gu
name: Weiwei You
name: Jianxin Zhang
name: Caihuan Ke
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Protein identification using MASCOT database searches. (DOC 238Â kb)
Liolaemus gravenhorstii
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus gravenhorstii

description: Liolaemus gravenhorstii (Gray)
Leiodera gravenhorstii Gray 1845: 211 (type locality: Santiago, Metropolitan Region, Chile, fide Hellmich 1934).
Proctotretus stantoni Girard 1854: 227 (synonym fide Donoso-Barros 1969b), 1855: 207.
Liolaemus (Ptychoideira) stantoni Girard 1858b: 374.
Liolaemus gravenhorstii Boulenger 1885a: 142; Hellmich 1934: 21; Pflaumer 1944: 113; Donoso-Barros & Candiani 1950: 485; Donoso-Barros 1966a: 180, 1970a: 183, 1970b: 91; Porter 1972: 401; Cei 1986: 252; Vanzolini 1986: 14; Veloso & Navarro 1988: 503; Laurent 1992: 31; Núñez & Jaksic 1992: 73; Etheridge 1995: 33; Lamborot & Vásquez 1998: 617; Etheridge & Espinoza 2000: 6; Lobo 2001: 139; Sura 2005: 429; Díaz & Lobo 2006: 264.
Liolaemus (Liolaemus) gravenhorstii Pincheira-Donoso & Núñez 2005: 241.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 25, DOI: 10.5281/zenodo.6789337
MOESM2 of Comparative characterization of all cellulosomal cellulases from Clostridium thermocellum reveals high diversity in endoglucanase product formation essential for complex activity
Creators: name: Leis, Benedikt
name: Held, Claudia
name: Bergkemper, Fabian
name: Dennemarck, Katharina
name: Steinbauer, Robert
name: Reiter, Alarich
name: Mechelke, Matthias
name: Moerch, Matthias
name: Graubner, Sigrid
name: Liebl, Wolfgang
name: Schwarz, Wolfgang
name: Zverlov, Vladimir
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2. Â Schematic representation of functional modules and primary amino acid sequence of synthesized scaffolding protein A from C. thermocellum.
Mechanisms of ephrin-B2 signaling mediating vasodilation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Peripheral arterial disease (PAD) involves the narrowing of the peripheral arteries, most commonly in the pelvis and the legs. If this blockage is serious, it can cause total loss of circulation in the legs, which may require amputation. People who smoke have an increased risk for PAD. Additionally, smoking and exposure to cigarette smoke are known to impair arterial dilation, further compounding the poor circulation in the limb. We have generated a mutant mouse lacking a protein called ephrinB2 in the blood vessels. When surgery is performed in normal mice to block an artery to simulate PAD, we expect the blocked-blood flow to be redirected to the other connecting vessels, causing vasodilation. Our mutant mice do not show vasodilation of the connected neighboring branches of the blocked artery to the same levels that their normal littermates do; they also recover much worse from the surgery, presenting a bluish color in the paws due to the scarcity of blood flow on the early stages after surgery, and severe gangrene on the following days. These preliminary findings reveal a novel, never described role of ephrinB2 in vasodilation. The aim of this proposal is to characterize the exact role and the mechanisms regulating the function of this protein, and validate it as a possible therapeutic target to improve blood flow in the acute response to severe arterial blockage.
Mapping the EphA Receptor Landscape in Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A main focus of the TRDRP is to accelerate research to understand and treat diseases caused by tobacco smoke, one of which is lung cancer. Tobacco smoke is very harmful, and can cause many changes to the normal lung (known as mutations). Normal lung function is dependent on many proteins working correctly, and when mutagenic chemicals found in tobacco smoke alter these proteins, this can lead to lung cancer. It has been established that certain proteins are changed (mutated) at a high frequency in lung cancer. In addition, recent large-scale genetic screening studies have revealed that many other proteins are also highly mutated. Among these are certain members of the EphA family. The EphA proteins are located on the cell surface, and regulate a wide variety of cellular processes, including cell growth, cell movement and the spatial organization of cells in tissues. EphA proteins can either increase or decrease cancer cell malignancy, depending a variety of factors that are not well understood. The focus of my research is on this EphA family of proteins, several of which have been found to be mutated in lung cancer. I hypothesize that different members of the EphA family have different functions in lung cancer, based on the findings that some have decreased expression and many mutations in lung cancer, while others have increased expression and few mutations. Therefore, some EphA proteins may act as tumor promoters and some as tumor suppressors. I anticipate that the information gathered from my studies will help physicians discriminate which EphA receptors would be suitable to target with drugs in order to reduce lung cancer progression.
Rhyzobius Stephens 1829
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Rhyzobius

description: Genus Rhyzobius Stephens, 1829
Among the following species, only Rhyzobius fagus (Broun) can be considered as a common species. All species are suspected to feed on Diaspididae, especially from the tribe Aspidiotini.
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 311, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Liolaemus gununakuna Avila, Morando, Perez & Sites 2004
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus gununakuna

description: Liolaemus gununakuna Avila, Morando, Perez & Sites
Liolaemus gununakuna Avila et al. 2004: 190 (type locality: 2 km SE La Amarga [39°06’S, 69°34’W], Zapala Department, Neuquen Province, Argentina); Sura 2005: 429; Scolaro 2006: 35.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 25, DOI: 10.5281/zenodo.6789337
Epigenetic effects of cigarette smoke on the infant airway
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoke exposure significantly increases one\'s risk of lung infections, with higher incidence, enhanced severity and longer lasting illnesses reported in smokers and those exposed to second hand smoke. It is unclear how cigarette smoke damages the immune system and reduces a person’s resistance to infection. Young children may be more sensitive to the effects of second hand smoke as the first year of life represents a development period for both the lung and the immune system. Many consider this early developmental phase a window of susceptibility for damage by air pollutants as exposure during this time has the potential to permanently affect the overall growth and function of the lung. Despite the abundant medical records correlating early life tobacco smoke exposures with increased incidence of lung infections, very little is known about the specific effects of cigarette smoke on the human infant lung due to the challenges and ethical concerns involved in studying the pediatric population. Neonatal animal models that mimic the developing human lung are critical for determining the impact of cigarette smoke exposure on an infant’s ability to fight lung infections. We propose that second hand cigarette smoke exposure during the first year of life results in permanent damage to infant immune cells in the lung. We will test if these smoke-exposed cells are functionally impaired and unable to fight against infections. The ultimate goal of this fellowship proposal is to gain a better understanding of how cigarette smoke exposure affects the infant immune system. From these studies we can expand into research aimed at identifying ways to either 1) improve immune function following cigarette smoke exposure or 2) prevent the damage caused by cigarette smoke.
Leptocera discalis Malloch
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sphaeroceridae
Leptocera
Leptocera discalis

description: discalis Malloch
Leptocera discalis Malloch, 1912b: 8. Linsley & Usinger 1966: 169 [checklist]; Richards 1967a: 8 [catalogue]; Linsley 1977: 42 [checklist].
Limnosina discalis: Curran 1932: 355 [records].
Leptocera fulva Malloch, 1912b. 4. Roháček et al. 2001: 154 [catalogue]; Buck & Marshall 2009: 107 [revision].
Distribution. Neotropical; Galápagos [doubtful record]: Floreana.
Remarks. This is a doubtful record [Roháček et al. 2001; Buck & Marshall 2009, under Leptocera fulva (Malloch)].
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 52, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Additional file 2: Table S2. of Proteomic analysis of trochophore and veliger larvae development in the small abalone Haliotis diversicolor
Creators: name: Guilan Di
name: Xianghui Kong
name: Xiulian Miao
name: Yifang Zhang
name: Miaoqin Huang
name: Yuting Gu
name: Weiwei You
name: Jianxin Zhang
name: Caihuan Ke
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Protein identification using MASCOT database searches. (DOC 238Â kb)
Delineating mechanisms of endothelial cytoprotection by APC
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco use is the leading risk factor contributing to premature mortality in the United States. One in five deaths from cardiovascular disease is attributed to smoking and accounts for over $157 billion annually in health-related economic costs. The detrimental effects of tobacco use include increased risk of hypertension and heart attacks where interruption of blood supply and subsequent oxygen deprivation to the heart causes heart cells to die. The most common cause of a heart attack is a blocked coronary artery caused by dislodged atherosclerotic deposits or plaques, masses of fatty acids and white blood cells that accumulate in the endothelium, a thin layer of cells that line the inner surface of blood vessels and is in contact with circulating blood. The endothelium acts as a barrier between the blood circulatory system and the surrounding tissue allowing selective passage of materials and plays important roles in blood clotting and blood pressure regulation. Cigarette smoke contains more than 60 known cancer-causing and toxic substances that promote endothelial cell injury and dysfunction by initiating inflammation and accumulation of atherosclerotic plaques in the endothelium. Smoking-induced endothelial dysfunction is an early event that contributes to the progression of chronic cardiovascular disease and has been linked to decreased levels of activated Protein C (APC), a naturally occurring anti-clotting agent in the blood. Human recombinant APC is the first FDA-approved drug for the treatment of severe sepsis, a life-threatening clinical condition resulting from uncontrolled inflammation and dysregulated blood clotting. The processes by which APC function remains poorly understood. The proposed studies will examine the role of APC in reducing endothelial inflammation to maintain endothelial barrier function and will provide a comprehensive pharmacological study of APC’s anti-inflammatory effects in endothelial cells from different types of blood vessels. Understanding how APC functions to protect the endothelium from inflammation caused by tobacco use will enable development of new strategies for drug targets in the prevention and treatment of tobacco-related cardiovascular disease and is expected to have substantial impact in reducing healthcare costs related to tobacco use.
Rhyzobius bielawskii Tomaszewska
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Rhyzobius
Rhyzobius bielawskii

description: Rhyzobius bielawskii Tomaszewska
Rhyzobius bielawskii Tomaszewska, 2010: 71.
Close morphologically to R. nigripennis Fauvel, it is easily distinguished by its smaller size and lack of spurs on the tibiae (Tomaszewska 2010). This endemic species has been recorded from various localities in New Caledonia along the Central Range from north to south of Grande Terre (Tomaszewska 2010), especially at high altitude (Mont Mou, Mont Do, Plateau de Dogny, Mont Panié). It has been recorded from both ultramafic and nonultramafic soils. Its biology is unknown, but it may be predaceous against coccids according to diet preference recorded for other Rhyzobius (Tomaszewska 2010).
Literature records. NEW CALEDONIA: Mt. Rembai, 700m, 18.x.1978 (G. Kuschel rec.) (MIZ); Mt. Rembai, 700m, 20.x.1978 (G. Kuschel rec.) (NZAC); Mt. Mou, 700m, 2.xi.1978 (G. Kuschel rec.) (NZAC); Mt. Do, 1000m, 31.x.1978 (J.C. Watt rec.) (NZAC); Mt. Do, 900-1030 m, 22.x.1978 (G. Kuschel rec.) (MIZ); Mt. Do, 900-1000 m, 31.x.1978 (G. Kuschel rec.) (NZAC); Col des Roussettes, 400m, 26.x.1978 (G. Kuschel rec.) (NZAC); Plateau de Dogny, 450 m, 10.iv.1973 (J.L. Gressit rec.) (BPBM); Col d’Amieu (1 km W of), 400 m, 21.37S, 165.49E, 10.ii.2004 (M. Wanat rec.) (ANIC & MIZ); Mts Koghi, 500-550 m, 22.11S, 166.30E, 21.i.2004 (M. Wanat rec.) (ANIC); Mont Panié, near refuge hut, 1300m, 20.33S, 164.46E, 2.ii.2004 (M. Wanat rec.) (ANIC) (Tomaszewska 2010).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 311, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Additional file 2: of Husk to caryopsis adhesion in barley is influenced by pre- and post-anthesis temperatures through changes in a cuticular cementing layer on the caryopsis
Creators: name: M. Brennan
name: T. Shepherd
name: S. Mitchell
name: C. Topp
name: S. Hoad
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Is a schematic of mass spectrometric fragmentation patterns to enable readers to understand how certain lipid compounds were identified using their characteristic fragmentations. (PDF 75Â kb)
Notch mediated mechanisms of mammalian cerebral angiogenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking dramatically increases the risk of cardiovascular disease, including various forms of cerebrovascular disease. Estimates suggest a smoker’s risk of developing cerebrovascular disease is 1.5 to 3 times greater than that of a nonsmoker. Cerebrovascular disease, including stroke and arterial-venous malformations, often lead to devastating neurological dysfunction. Indeed, 50% of survivors of cerebrovascular disease experience neurological deficit, half of which require chronic care. In the United Stated alone, over 15,000 deaths per year are directly attributed to smoking-induced cerebrovascular disease; however, the mechanisms that trigger cerebrovascular disease remain poorly understood. The vasculature plays a principal role in health and disease, by providing a vital platform for perfusion and nutrition of tissues. Smoking has been shown to reduce the ability of the blood to transport oxygen, thereby adversely affecting tissue health. In particular, the tissue lining blood vessels - vascular endothelium - is damaged by components of cigarette smoke. Herein, we propose experiments to investigate genetic mechanisms enacted within the vascular endothelium of the brain. Our goal is to understand the mechanisms that promote the growth of new and existing blood vessels within the brain.We propose an analysis of the dynamic remodeling of blood vessels within the brain shortly after birth. While many blood vessels have already been established by birth, the organization and ultimate function(s) of these vessels is not yet mature. In particular, we will study the role of a specific gene (called Notch) during this maturation phase for blood vessels within the brain. By altering Notch gene function specifically in cells (vascular endothelial cells) lining these blood vessels, we hope to understand the normal function of the Notch gene product in the brain vasculature. As our long-term interests lie in the development, function, and disease state of human blood vessels within the brain, we use another mammal - the mouse - as an appropriate and applicable experimental model system to inform on events relevant to human biology. The success of these studies will provide conceptual advances toward understanding the normal course of blood vessel formation in the brain and fostering therapeutic advances for cerebrovascular disease.
Liolaemus heliodermis Espinoza, Lobo & Cruz 2000
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus heliodermis

description: Liolaemus heliodermis Espinoza, Lobo & Cruz
Liolaemus heliodermis Espinoza et al. 2000: 509 (type locality: Provincial Road 307, about 32 km from Tafí del Valle, Tafí del Valle Department, Tucumán Province, Argentina); Etheridge & Espinoza 2000: 6; Avila et al. 2003: 534; Hernández & Espinoza 2004: 227; Chebez et al. 2005: 32; Sura 2005: 429; Díaz & Lobo 2006: 264; Díaz 2007: 114.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 25, DOI: 10.5281/zenodo.6789337
Leptocera erythrocera
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sphaeroceridae
Leptocera
Leptocera erythrocera

description: erythrocera (Becker)
Limosina erythrocera Becker, 1920: 183.
Leptocera erythrocera: Roháček et al. 2001: 153 [catalogue]; Buck & Marshall 2009: 34 [revision].
Leptocera (Leptocera) abdominiseta Duda, 1925a: 52. Richards 1967b: 531 [records]; Roháček et al. 2001: 153 [as syn. of L. erythrocera].
Leptocera abdominiseta: Linsley 1977: 42 [checklist].
Distribution. Introduced. Cosmopolitan; Galápagos: Floreana, San Cristobal, Santa Cruz, Santa Fé, Santiago.
Remarks. This species breeds in decaying vegetation.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 53, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Rhyzobius fagus Broun
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Rhyzobius
Rhyzobius fagus

description: Rhyzobius fagus (Broun)
Scymnus fagus Broun, 1880: 648.
Rhizobius satelles Blackburn, 1892: 255 —synonymized by Tomaszewska 2010: 109. Rhizobius kingensis Lea, 1908: 206 —synonymized by Tomaszewska 2010: 109. Rhizobius erythrogaster Lea, 1929: 241 —synonymized by Tomaszewska 2010: 109. Rhyzobius nigrovatus Bielawski, 1973: 391 —synonymized by Tomaszewska, 2010: 109.
Some misidentifications of this species have led to false records in the literature from New Caledonia (Huffaker & Messenger 1976): Lindorus lophanthae (Blaisdell) and Rhyzobius pulchellus (Montrouzier). Bielawski (1973) made a new description under Rhyzobius nigrovatus (type locality: Nouméa). Tomaszewska (2010) redescribed this species and gave an account of its geographic range. This Australian species appears to have recently spread to New Caledonia and Vanuatu, where it is now quite common. In Vanuatu, it has been heavily used and promoted against the coconut scale Aspidiotus destructor Signoret (Hemiptera: Diaspididae) between 1960 and 1980 (Chazeau 1981b). This efficient diaspidid feeder was also deliberately introduced to the Caroline Islands (Nafus & Schreiner 1989) and Wallis Island in 1965. It has been seen established in Wallis in 1981 (Gutierrez 1981), and also in South Africa (before 1988). Apart from Aspidiotus destructor Signoret, it has been seen to feed on Aspidiotus nerii Bouché, Aulacaspis tubercularis Newstead, Pseudaulacaspis pentagona (Targioni-Tozzetti), Lepidosaphes beckii (Newman) (Cochereau 1965, 1969).
Literature records. NEW CALEDONIA: Nouméa (A. Fauvel rec.) (ISNB); Nouméa, 0-100m, ii.1980 (N.H.L. Krauss rec.) (BPBM); Nouméa, 0-100m, 3.iii.1980 (N.H.L. Krauss rec.) (BPBM); Hills behind Nouméa, 15.viii.1940 (F.X. Williams rec.) (BPBM); Nouméa, 26.vii.1940 (F.X. Williams rec.) (BPBM); Nouméa, 24.vii.1940 (F.X. Williams rec.) (BPBM); Nouméa, 13.viii.1940 (F.X. Williams rec.) (BPBM); In Mts. above Ouaco, 20.x.1958 (C.R. Joyce rec.) (BPBM); Koebele (BPBM); La Crouen, 16.iii.1961 (J. Sedlacek rec.) (BPBM); Poindimié, 26.xi.1958 (C.R. Joyce rec.) (BPBM); Mt Mou, 1100 m, 9.iii.1972 (J.L. Gressit rec.) (BPBM); Mokoue to Dothio, 150-500 m, 20-22.iii.1968 (T.C. Maa rec.) (BPBM) (Tomaszewska 2010).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 311, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Liolaemus hellmichi Donoso-Barros 1974
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus hellmichi

description: Liolaemus hellmichi Donoso-Barros
Liolaemus hellmichi Donoso-Barros 1974b: 224 (type locality: Cerro Moreno, Antofagasta, Antofagasta Region, Chile); Vanzolini 1986: 14; Veloso & Navarro 1988: 504; Laurent 1992: 31; Núñez & Jaksic 1992: 73; Etheridge 1995: 33; Etheridge & Espinoza 2000: 6; Escobar et al. 2001: 1679; Lobo 2001: 139; Sura 2005: 429; Díaz & Lobo 2006: 264.
Liolaemus (Liolaemus) hellmichi Pincheira-Donoso & Núñez 2005: 422.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 25, DOI: 10.5281/zenodo.6789337
Regulation of APC-mediated PAR1 signaling
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking causes cardiovascular disease, a leading cause of death in the United States. More than 61 million Americans suffer from some form of cardiovascular disease, and health care costs for people with health problems related to smoking has risen to tens of billions of dollars according to health economists at the University of California. Smoking generates toxins that are absorbed into the bloodstream, directly contributing to the damage of endothelial cells, which are cells that line the blood vessel wall. Smoke-induced endothelial cell dysfunction is a contributory factor to many long-term effects on the cardiovascular system. Endothelial cell dysfunction promotes thrombosis (blood clots), the formation of which is a critical event in myocardial infarction (heart attacks) and stroke.

 Thrombosis is initiated by a blood-borne protease known as thrombin. Thrombin formed during injury or inflammation acts locally and under nonpathological conditions thrombin activity is rapidly inhibited by the vascular endothelium. One molecule that regulates the generation of thrombin and protects against thrombosis is known as activated protein C (APC). APC also promotes cytoprotective signaling in endothelial cells through a poorly understood mechanism. Moreover, endothelial cell damage induced by smoking has been linked to decreased APC generation, which can contribute to thrombosis. Remarkably, thrombin and APC stimulate endothelial cellular responses through the same receptor, Protease-Activated Receptor 1 (PAR1). Precise regulation of PAR1 signaling is crucial for proper endothelial cell function. The focus of this proposal is to understand the molecular basis by which PAR1 signaling is regulated following activation by APC in human endothelial cells. This knowledge is critical for developing novel strategies and for identifying new targets that can be used in the prevention and treatment of vascular endothelial cell dysfunction, a pathological condition associated with smoking and a major cause of cardiovascular disease.