cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Temperature-Dependent Sex Determination in Manouria Emys Emys, The Asian Forest Tortoise
Creators: name: Emer, Sherri
Publisher: name: Georgia State University
Year: 2007

description: Captive husbandry programs in zoos have documented nesting behavior and have successfully hatched Manouria emys emys, but data on sex determining mechanisms and sex ratios are absent. A total of 30 M. e. emys eggs were artificially incubated at five different temperatures in constant humidity. Mean incubator temperatures were 24.99øC, 25.06øC, 27.18øC, 28.00øC, and 30.79øC. Incubation duration ranged from 60 days to 92 days, and hatching success was 50%. Sex determined by histology and laparoscopy resulted in male differentiation at low temperatures (24.99øC, 27.18øC) and female differentiation at high temperatures (30.79øC). Pivotal temperature was estimated to be 29.29øC. The following investigation into temperature-dependent sex determination (TSD), including its presence or absence, pattern, and pivotal temperature, has implications for studies of adaptive significance of reproductive behaviors and of chelonian phylogenetic history. Additionally, the proposed study can provide foundations for conservation management decisions, and for captive breeding programs.
Differential Effects of Estrogen Receptor alpha Suppression by Antisense Oligodeoxynucleotides in the Medial Preoptic Area and the Medial Amygdala on Male Rat Mating Behavior
Creators: name: Paisley, Jacquelyn
Publisher: name: Georgia State University
Year: 2007

description: Male rat copulation is mediated by estrogen-sensitive neurons in the medial preoptic area (MPO) and medial amygdala (MEA); however, the mechanisms through which estradiol (E2) acts are not fully understood.  We hypothesized that E2 acts through estrogen receptor α (ERα) in the MPO and MEA to promote male mating behavior.  Antisense oligodeoxyneucleotides (AS-ODN) complementary to ERα mRNA were bilaterally infused via minipumps into either brain area to block the synthesis of ERα, which we predicted would reduce mating.  Western blot analysis and immunocytochemistry revealed a knockdown of ERα in each brain region; however, compared to saline controls, males receiving AS-ODN to the MPO showed significant reductions in all components of mating, whereas males receiving AS-ODN to the MEA continued to mate normally.  These results suggest that E2 acts differently in these brain regions to express sexual behavior and that ERα in the MPO, but not in the MEA, promotes mating.
title: Die Bedeutung der Klassenfrequenz im Urteil der Lehrer
title: Eine empirische Untersuchung in der Sekundarstufe I in Rheinland-Pfalz
titleType: Subtitle
Creators: name: Saldern, Matthias von
name: Katz, Petra
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2003
Subjects: subject: Schulklasse
classificationCode: 372
subject: 372 Primar- und Elementarbildung

description: Lehrerbefragung zum Thema Klassenfrequenz
title: Japanese-German-Symposium: Work Style Reform and Gender Equality in Japan and Germany – Report
Creators: name: Kottmann, Nora
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2019
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2019, no. 44, p. 78
Reinforcing Efficacy of Amphetamine in Adolescent and Adult Male Rats
Creators: name: Payne, Lauren
Publisher: name: Georgia State University
Year: 2008

description: Rationale: Amphetamine abuse by adolescents predicts long-term drug dependence. Heightened vulnerability to drug abuse could be due to higher sensitivity to drug?s reinforcing effects. Rodents are used to study age-related sensitivities to drugs. Objective: We compared intravenous amphetamine self-administration between adolescent and adult male rats on an operant schedule of reinforcement measuring the reinforcing efficacy of a drug. Methods: After surgery, adolescent and adult rats acquired lever-pressing behavior reinforced by amphetamine infusions. Results: Both age groups exhibited more infusions per session as dose increased. However, neither the number of infusions per session nor total amphetamine intake differed across age groups. Conclusion: Although rapid transition is reliable to test reinforcing properties of stimulants, results suggest that amphetamine is an equally efficacious reinforcer among both age groups. In regards to humans, these results suggest that other factors, like social influences, explain higher rates of drug intake by adolescent compared with adult humans.
Mapping and Filling Metabolic Pathway Holes
Creators: name: Kaur, Dipendra
Publisher: name: Georgia State University
Year: 2008

description: The network-mapping tool integrated with protein database search can be used for filling pathway holes. A metabolic pathway under consideration (pattern) is mapped into a known metabolic pathway (text), to find pathway holes. Enzymes that do not show up in the pattern may be a hole in the pattern pathway or an indication of alternative pattern pathway. We present a data-mining framework for filling holes in the pattern metabolic pathway based on protein function, prosite scan and protein sequence homology. Using this framework we suggest several fillings found with the same EC notation, with group neighbors (enzymes with same EC number in first three positions, different in the fourth position), and instances where the function of an enzyme has been taken up by the left or right neighboring enzyme in the pathway. The percentile scores are better when closely related organisms are mapped as compared to mapping distantly related organisms.
The C-Phycocyanin/Beta Protein Inhibits Cancer Cell Proliferation
Creators: name: Wang, Haizhen
Publisher: name: Georgia State University
Year: 2008

description: C-Phycocyanin (C-PC) from blue-green algae has been reported to have various pharmacological characteristics, including anti-inflammatory and anti-cancer activities. In this study, the beta-subunit of C-PC (ref to as C-PC/beta) was expressed and purified from bacteria E. coli BL-21. The recombinant C-PC/beta has been demonstrated to have anticancer properties. Under the treatment of 5 microM of the recombinant C-PC/beta, four different cancer cell lines accrued a high proliferation inhibition and apoptotic induction. The C-PC/beta interacts with membrane-associated beta-tubulin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been found. Under the treatment of the C-PC/beta, depolymerization of microtubulin and actin-filament was observed. The cells underwent apoptosis with increase of Caspase-3 and Caspase-8 activities. Cell cycle was arrested at G0/G1 phase under the treatment of C-PC/beta. In addition, the nuclear level of GAPDH decreased significantly. Inhibition of cancer cell proliferation and induction of apoptosis may potentate C-PC/beta as a promising cancer prevention or therapy agent.
title: Arbeitstagung der Konferenz der Einrichtungen für Frauen- und Geschlechterstudien im deutschsprachigen Raum (KEG) 2019: Bericht zur Tagung vom 3. bis 4. Juli 2019 an der FernUniversität in Hagen
Creators: name: Wrede, Birgitta
name: Pache, Ilona
name: Amacker, Michèle
name: Ellmeier, Andrea
name: Schulz, Dirk
Publisher: name: DuEPublico: Duisburg-Essen Publications online, University of Duisburg-Essen, Germany
Year: 2019
Subjects: subject: 300

description: Journal Netzwerk Frauen- und Geschlechterforschung NRW, vol. 2019, no. 44, p. 84
Production of B Virus Glycoprotein D and Evaluation of its Diagnostic Potential
Creators: name: Filfili, Chadi
Publisher: name: Georgia State University
Year: 2008

description: B virus diagnosis presents a challenge largely complicated by the asymptomatic infection
of rhesus macaques, and extremely pathogenic fatal infections in humans. Humoral detection of antibodies is generally performed using whole virus antigen for which
preparation requires strict biosafety measures and specialized BSL-4 facilities. As an
alternative to utilizing B virus antigen, we describe the production of a truncated form of
B virus envelope glycoprotein D, gD 287, in a baculovirus expression system, and
evaluate its diagnostic potential as an antigen in recombinant ELISA. After purification
and characterization, gD 287 was tested using 22 negative and 72 positive macaque sera
samples previously classified using the traditional method. We find that sensitivity and
specificity of the recombinant ELISA are dependent on antibody titer of tested serum and gD 287 shows good to excellent predictive potential for identification of positive sera with titers higher than 500.
Computer Forecasting of Australian Rules Football for a Daily Newspaper
Creators: name: Clarke, Stephen
Publisher: name: Swinburne
Year: 2024

description: An exponential smoothing technique operating on the margins of victory was used to predict the results of Australian Rules football matches for a Melbourne daily newspaper from 1981-86 and again for a competitor in 1991-92. An initial quick and dirty program used only a factor for team ability and a common home ground advantage to predict winning margins. Probabilities of winning were accumulated to predict a final ladder, with a simulation to predict chances of teams finishing in any position. Changes to the competition forced a more complicated approach, and the current version uses several parameters which allow for ability, team/ground interaction, team interaction, and a tendency for team ability to regress towards the mean between seasons. A power method is used to place greater weight on the errors in closer matches, and errors across the win-lose boundary. While simple methods were used originally, the Hooke and Jeeves method was used in optimizing the parameters of the current model. Both the original model and the improved version performed at the level of expert tipsters. © 1993 Operational Research Society Ltd.
Datenstrukturen und Algorithmen
Creators: name: Hoffmann, Ulrich
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2006
Subjects: subject: Programmierung
classificationCode: 004
subject: 004 Datenverarbeitung; Informatik

description: Das vorliegende Skript dient als begleitende Unterlage für die Veranstaltungen Datenstrukturen und Systemnahe Programmierung an der Universität Lüneburg.
Aspekte zur Theorie der Friedenspädagogik
Creators: name: Kerscher, Ignatz
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2005
Subjects: subject: Friedenserziehung
subject: Pädagogik
classificationCode: 370
subject: 370 Bildung und Erziehung

description: Die weltweiten Friedensdemonstrationen mit Millionen von Teilnehmern und Teilnehmerinnen der vergangenen Jahre 2002/2003 zeigen den Wunsch eines großen Teiles der Menschheit nach Frieden. Die Aktivität hunderttausender junger Menschen für den Frieden ist in Deutschland ein neuartiges Phänomen, das zum Teil als ein Resultat jahrzehntelanger Friedenserziehung und Friedenspädagogik in Elternhäusern, Kindergärten, Schulen und Hochschulen angesehen werden kann.
Cholangitis Definition and Treatment after Kasai Hepatoportoenterostomy for Biliary Atresia: A Delphi Process and International Expert Panel
Creators: name: Calinescu, Ana M.
name: Madadi-Sanjani, Omid
name: Mack, Cara
name: Schreiber, Richard A.
name: Superina, Riccardo
name: Kelly, Deirdre
name: Petersen, Claus
name: Wildhaber, Barbara E.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: (1) Background: Acute cholangitis during the first year after Kasai hepatoportoenterostomy (HPE) has a negative impact on patient and native liver survival. There are no consistent guidelines for the definition, treatment, and prophylaxis of cholangitis after HPE. The aim of this study was to develop definition, treatment, and prophylaxis guidelines to allow for expeditious management and for standardization in reporting. (2) Methods: the Delphi method, an extensive literature review, iterative rounds of surveys, and expert panel discussions were used to establish definition, treatment, and prophylaxis guidelines for cholangitis in the first year after HPE. (3) Results: Eight elements (pooled into two groups: clinical and laboratory/imaging) were identified to define cholangitis after HPE. The final proposed definitions for suspected and confirmed cholangitis are a combination of one element, respectively, two elements from each group; furthermore, the finding of a positive blood culture was added to the definition of confirmed cholangitis. The durations for prophylaxis and treatment of suspected and confirmed cholangitis were uniformly agreed upon by the experts. (4) Conclusions: for the first time, an international consensus was found for guidelines for definition, treatment, and prophylaxis for cholangitis during the first year after Kasai HPE. Applicability will need further prospective multicentered studies.
Lernumwelt-Anspruch und Wirklichkeit aus der Sicht von Lehrern
Creators: name: Saldern, Matthias von
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2001
Subjects: Lernumwelt

description: Aus den Forschungen zur Berufszufriedenheit ist bekannt, dass Zufriedenheit auch als Differenz zwischen tatsächlichen und gewünschten Arbeitsverhältnissen verstanden werden kann. An dieser Stelle verknüpft sich die Berufszufriedenheitsforschung mit der Erforschung der Lernumwelt. An einem empirischen Beispiel mit Lehrern aus 7. Hauptschulklassen wird aufgezeigt, dass große Diskrepanzen zwischen der realen und der idealen Lernumwelt bestehen. Diese Diskrepanz erlaubt Rückschlüsse auf die Zufriedenheit von Lehrern. Der Vorteil diese Vorgehens ist es, dass man inhaltlich differenziert vorgehen kann und nicht darauf angewiesen ist, Zufriedenheit als globales Konstrukt verwenden zu müssen.
Postmodern Childhood in Germany
Creators: name: Kerscher, Ignatz
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2005
Subjects: subject: Postmoderne
subject: Kind
classificationCode: 370
subject: 370 Bildung und Erziehung

description: Übersicht über Aspekte der modernen Kindheit
Induction of Apoptosis by Rubella Virus Non-Structural Replicase and Rescue by Capsid
Creators: name: Kanak, Alison
Publisher: name: Georgia State University
Year: 2008

description: As a model for studying apoptosis associated with pathogenesis of congenital rubella syndrome, bicistronic rubella virus (RUBV) replicons expressing an antibiotic resistance gene in the presence (925-IN) or absence (IN-IN) of RUBV capsid protein (C) were constructed. Apoptosis was assessed by detection of caspase activation, chromatin fragmentation, and flow cytometry. 925-IN cells grew similarly to Vero, but IN-IN cells demonstrated caspase activation, chromatin fragmentation and cell cycle arrest. Whereas Vero cells transfected with P150 exhibited rapid apoptosis not detected in transfected Vero cells stably expressing C, neither exhibited cell cycle alterations, indicating a cell cycle stall not associated with apoptosis. Finally, two human epithelial cells, HEK293 and A549, transfected with P150 failed to exhibit apoptosis, indicating that while replicon-transfected Vero cells are useful for studying apoptosis and cell cycle arrest, the results are not applicable to other cell types.
Comparative Study of HPV 16 and HPV 18 Antibody Detection in Serum, Cervical Mucus, and Oral Mucosal Transudate
Creators: name: Blalock, Emily
Publisher: name: Georgia State University
Year: 2008

description: Measuring HPV exposure relies on detection of HPV type-specific antibodies, but methods are not standardized.  Additionally, there is little information on the best sample type for HPV antibody detection.  This study validated pseudovirion neutralization (PVN) assay for HPV antibody detection and compared it to IgG ELISA.  Both assays were applied to paired serum and cervical mucus samples.  Additionally, PVN assay was utilized to evaluate the feasibility of oral mucosal transudate (OMT) samples to monitor the HPV immune response.  Serum was more likely to be positive on PVN assay than on IgG ELISA (p= 0.025). Both assays correlated with HPV-16 DNA status.  HPV-18 PVN assay results correlated with HPV-18 DNA status.  Few cervical mucus samples had detectable antibodies; no correlation with HPV DNA status was seen.  OMT results were unsatisfactory.   PVN assay was more sensitive than IgG ELISA; serum was a more reliable indicator of HPV-16/18 antibody status than cervical mucus.
The Production of Designed Potential Protein Contrast Agents and their Encapsulation in Albumin Microspheres
Creators: name: Johnson, Julian
Publisher: name: Georgia State University
Year: 2008

description: Using protein design, a series of metal binding proteins have been designed,
allowing the local factors that contribute to metal affinity and thermostability to be studied. Those proteins with the highest metal binding affinities had the lowest apo-form
Tm and the largest ŽTm upon metal binding. In this thesis, major steps have been taken
toward applying the engineered protein to MR imaging. The progress of magnetic resonance imaging is hindered by low specificity and rapid elimination of FDA-approved MRI contrast agents. The engineered protein contrast agent has been conjugated to a cancer-specific targeting peptide and encapsulated in albumin microspheres to provide tandem passive and active tumor targeting. Also, a simple, high-yield purification method has been developed.
To Degrade or Not to Degrade: The Role of P300/CBP-Associated Factor (PCAF) in Ciita Stability and Ubiquitination
Creators: name: Brooks, Jeanne
Publisher: name: Georgia State University
Year: 2009

description: The ubiquitin-proteasome pathway plays vital roles in multiple cellular processes including protein turnover and transcription regulation.  The fate of a ubiquitinated protein is determined by the number of ubiquitin molecules added and the site to which they are added.  Monoubiquitinated proteins are stabilized and often activated, while polyubiquitinated proteins are rapidly targeted for degradation.  Major histocompatibility complex class II (MHC II) molecules are a vital part of the immune response and are responsible for presenting antigens to CD4+ T cells.  The class II transactivator (CIITA) is the master regulator of MHC II transcription and has been shown to have increased transactivity when monoubiquitinated.   The focus of this thesis is on the impact of ubiquitination on CIITA stability and MHC II gene expression through the identification of an E3 ligase that targets and ubiquitinates CIITA.
XR4Human D4.2_Co-Creation of an Interoperability Guideline
Creators: name: Salazar, Mikel
name: Kadlubsky, Alina Kadlubsky
Publisher: name: Zenodo
Year: 2024
Subjects: Interoperability Guide
Knowledge Management
Visualization

description: This report presents the results of the task 4.2 of the XR4HUMAN project; an Interoperability Guide presented as a transit map. A living document that aims to not only facilitate the understanding of XR technologies, but to improve the communication between the different stakeholders involved in this project.
Functional Analysis of the Heme and Hemoglobin Binding Domains of SHR (Streptococcal Hemoprotein Receptor)
Creators: name: Bentley, Elizabeth
Publisher: name: Georgia State University
Year: 2009

description: Streptococcus pyogenes (Group A Streptococcus) is a Gram-positive bacterial pathogen that causes significant superficial and invasive diseases. Iron acquisition is an important component of GAS pathogenesis in the human host. The 10 gene sia operon of GAS is involved in the acquisition of iron via heme or heme-binding proteins and encodes an ABC transporter as well as the large multifunctional receptor Shr. Domain analysis of Shr shows that it contains two copies of the DUF1533 (domain of unknown function) in its N-terminal part and two NEAT (NEAr Transporter) domains. NEAT domains are found in variable copy number in surface proteins of Gram-positive pathogens and are implicated in binding to various ligands. A new recombinant Shr protein was cloned and a purification protocol was developed, improving the yield of the full-length protein. A solid phase binding assay was developed and used to demonstrate Shr binding to hemoglobin. Several truncated Shr proteins were expressed and purified: the N-terminal Domain (NTD) up to but not including the first NEAT domain of Shr, the NTD plus the first NEAT domain (NTD-NEAT1) and the second NEAT domain alone (NEAT2). It was determined that Shr?s NTD mediates hemoglobin binding, demonstrating that a new protein pattern in Shr is involved in hemoglobin binding, and implicating the DUF1533 in this process. It was also determined that NTD-N1 and NEAT2 bind heme while NTD does not. Therefore, both NEAT domains may participate in the capture of heme from the host hemoglobin by Shr.
Subcloning, Expression, and Enzymatic Study of PRMT5
Creators: name: Guo, Ran
Publisher: name: Georgia State University
Year: 2010

description: Protein arginine methyltransferases (PRMTs)mediate the transfer of methyl groups to arginine residues in histone and non-histone proteins. PRMT5 is an important member of PRMTs which symmetrically dimethylates arginine 8 in histone H3 (H3R8) and arginine 3 in histone H4 (H4R3). PRMT5 was reported to inhibit some tumor suppressors in leukemia and lymphoma cells and regulate p53 gene, through affecting the promoter of p53. Through methylation of H4R3, PRMT5 can recruit DNA-methyltransferase 3A (DNMT3A) which regulates gene transcription. All the above suggest that PRMT5 has an important function of suppressing cell apoptosis and is a potential anticancer target. Currently, the enzymatic activities of PRMT5 are not clearly understood. In our study, we improved the protein expression methodology and greatly enhanced the yield and quality of the recombinant PRMT5. In addition, mutagenesis and enzymatic studies implicate an interesting mechanism of PRMT5 activity regulation.
Estrogen Receptor Alpha in the Medial Preopic Area Mediates Male Rat Sexual Responses to Estrogen
Creators: name: Russell, Nancy
Publisher: name: Georgia State University
Year: 2010

description: Male rat sexual behavior requires aromatization of testosterone (T) to estradiol (E2) in the medial preoptic area (MPO) where estrogen receptors (ER) exist in two isoforms, ERà and ER?. We hypothesized that E2 acts through estrogen receptor à (ERà) in the MPO to promote male mating behavior. Four groups of male rats were castrated, administered DHT s.c. and bilateral MPO implants delivering either: cholesterol, E2, propyl pyrazole triol (PPT, ERà agonist), diarylpropionitrile (DPN, ER ? agonist), or 1-methyl-4-phenyl pyridinium (MPP, ERà antagonist). Additional gonadally intact males received bilateral MPO DPN implants. PPT maintained sexual behavior equally as well as E2, whereas mating was not maintained by cholesterol or DPN MPO implants. Exogenous T did not reinstate mating in animals that received MPP MPO implants. These findings indicate that, in the MPO, ERà is necessary and sufficient to promote copulatory behavior in male rats and ER? is not sufficient for mating.
Mathematik für Wirtschaftsinformatiker: Übungen mit Lösungen
Creators: name: Hoffmann, Ulrich
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2006
Subjects: subject: Wirtschaftsinformatik
subject: Angewandte Mathematik
classificationCode: 004
subject: 004 Datenverarbeitung; Informatik

description: Das vorliegende Skript dient als Unterlage für die Veranstaltung Mathematik für Wirtschaftsinformatikerinnen und Wirtschaftsinformatiker am Fachbereich Wirtschaft. Es enthält Übungen mit Lösungen zu dem Skript "Mathematik für Wirtschaftsinformatiker".
Early Epigenetic Regulation of the Adaptive Immune Response Gene CIITA
Creators: name: Mehta, Ninad
Publisher: name: Georgia State University
Year: 2010

description: The precise regulation of Major Histocompatibility class II (MHC-II) genes plays an important role in the control of the adaptive immune response. MHC-II genes are expressed constitutively in only a few cell types, but their expression can be induced by the inflammatory response cytokine interferon gamma (INF-?). The regulation of MHC-II is controlled by a Master Regulator, the class II transactivator (CIITA). Multiple studies have shown that CIITA regulated expression of MHC-II is controlled and induced by INF-?. It has been also shown that a functional CIITA gene is necessary for the expression of MHC-II genes. CIITA is thus a general regulator of both constitutive and inducible MHC-II expression. Although much is known about the transcription factors necessary for CIITA expression, there is little information as to the epigenetic modifications and the requisite enzymes needed to provide these transcription factors access to DNA. Previous studies in the Greer lab have shown that increased levels of acetylation of histones H3 upon INF-? stimulation, as does tri-methylation of H3K4 upon prolonged cytokine stimulation. Similar observations were made at early time points post IFN-? stimulation, where there is an instantaneous increase in the levels of H3K18ac and H3K4me3. In contrast to this, the levels of silencing modifications begin to drop with in the first 20 minutes of IFN-? stimulation. The binding of STAT1 reaches its peak at about 60 minutes and the first transcripts for the protein start to appear as early as 40 minutes post the cytokines stimulation. Our study is the first to link the rapidly occurring epigenetic changes at the CIITA promoter pIV to EZH2
E-stability and stability of adaptive learning in models of asymetric information
Creators: name: Heinemann, Maik
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2007
Subjects: subject: Learning
subject: Eductive Stability
subject: Rational Expectations
subject: Lernen
subject: Erwartung
subject: Stabilität
classificationCode: 330
subject: 330 Wirtschaft

description: The paper demonstrates how the E–stability principle introduced by Evans and Honkapohja can be applied to models with heterogeneous and private information in order to assess the stability of rational expectations equilibria under learning. The paper extends already known stability results for the Grossman and Stiglitz model to a more general case with many differentially informed agents and to the case where information is endogenously acquired by optimizing agents. In both cases it turns out that the rational expectations equilibrium of the model is inherently E-stable and thus locally stable under recursive least squares learning.
Systemanalyse für Softwaresysteme
Creators: name: Bonin, Hinrich E. G.
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2006
Subjects: subject: Wirtschaftsinformatik
subject: Systemanalyse
subject: Software Engineering
classificationCode: 004
subject: 004 Datenverarbeitung; Informatik

description: Systemanalyse für Softwaresysteme ist ein Manuskript zum Selbststudium und zur Begleitung von Lehrveranstaltungen. Es vermittelt eine Einführung in die Systemanalyse in diesem Informatik-Kontext. Systemanalyse wird dargestellt als ein zielorientiertes Vorgehen mit vielfältigen Konkretisierungs- und Abstraktionsaktivitäten. Die Vorgehensweise wird anhand von Beispielen erläutert.
Frontrunners but different games? Comparing Catalan and Basque paradiplomacy towards the EU
Creators: name: Antunes, Sandrina
name: Cornago, Noé
name: Lecours, André
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Mental Health

description: This article compares Basque and Catalan mobilisation towards the EU over the period from 1992 to 2022. The contrasting trajectories of these regions are approached through the conceptual framework of ‘paradiplomacy’ and ‘protodiplomacy’. Building on a combination of primary and secondary sources, six explanatory variables are selected and the observed patterns compared across time. Both cases alternate between cooperation and benign neglect, becoming politically controversial only when the regions overtly express claims for self-determination; however, only the Catalan case involves a severe and lasting political conflict. Although the strategies are framed by the broader structures of opportunity imposed by the EU, our research shows that the most salient features of these contrasting trajectories are deeply rooted in the idiosyncrasies of the Spanish political system and individual leadership styles. These findings help us to understand the scope and limits of paradiplomacy in other settings in which the continuum between intergovernmental cooperation, conflict and benign neglect has repercussions beyond state borders in the EU.
Impact of Aging on Morphine Analgesia and Associated Changes in ?-Opioid Receptor Binding and Expression in the Ventrolateral Periaqueductal Gray
Creators: name: Hanberry, Richard
Publisher: name: Georgia State University
Year: 2010

description: Chronic pain in the aged is a widespread phenomenon, and morphine is the most commonly used narcotic analgesic for treatment. Despite that fact, there are relatively few published studies examining the impact of advanced age on morphine analgesia. We hypothesized that aged rats would be less sensitive to morphine than adults, and that aged animals would have reduced mu-opioid receptor (MOR) binding and expression in the ventrolateral periaqueductal gray, a brain region responsible for morphine analgesia. Using a model of persistent inflammatory pain, we found that morphine was significantly less effective in aged males compared to adult males, and that aged males and females experience a reduction in MOR binding and expression compared to adults. These results suggest that there are clear age differences in morphine efficacy, and that reductions in MOR binding and expression in the periaqueductal gray could underlie those differences.
Globalisierung, Postmoderne und Orientierungsprobleme der Sexualpädagogik
Creators: name: Kerscher, Ignatz
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2005
Subjects: subject: Postmoderne
subject: Globalisierung
subject: Sexualerziehung
classificationCode: 370
subject: 370 Bildung und Erziehung

description: Im Kontext einer Sexualpädagogik der Gegenwart stellt sich die Frage, wie sich globale Strömungen und Veränderungen auf individuelles Denken, Erleben und Verhalten – bis hin zum sexuellen Sektor der menschlichen Lebensäußerungen – auswirken mögen und wo die Sexualpädagogik Orientierungspunkte findet.
Differential Gene Expression in Bugula Neritina during Symbiotic Association with "Candidatus Endobugula Sertula"
Creators: name: Mathew, Meril
Publisher: name: Georgia State University
Year: 2010

description: The colonial marine bryozoan, Bugula neritina, harbors an uncultured endosymbiont, ?Candidatus Endobugula sertula? throughout its life stages. The bacterial symbiont has been proposed to be a source of complex polyketide metabolites, the bryostatins, that chemically defend B. neritina larvae from predation. Within a bryozoan colony, significantly higher amounts of bryostatins are found in ovicell-bearing zooids where the developing larvae are brooded, as compared to ovicell-free zooids. It is hypothesized that signaling between B. neritina and ?Ca. Endobugula sertula? may be involved in the regulation of bryostatin production in different zooids, as well as in maintenance of the symbiosis. In this study, suppression subtractive hybridization (SSH) was used to identify differentially expressed host genes during this association. The identified genes suggest that the host plays a role in the distribution and localization of bacterial symbionts in different host zooids, possibly to regulate levels of bryostatin production in the zooids.
Cours Research4Life, DOAJ, ASSAf. Module 4 : Maintenir l'intégrité et l'éthique de la recherche
Creators: name: García Reátegui, Gala
Publisher: name: Zenodo
Year: 2024
Subjects: open access
science ouverte

description: Voici le matériel du Module 4 du cours accrédité sur les revues en accès ouvert.

Ce cours a été réalisé en collaboration avec Research4Life, le DOAJ et l'ASSAf.
New Challenger for Sustainable Ethanol Production in Industrial Biorefineries
Creators: name: Hernandez, Jesus Ernesto
name: Espinosa-Solares, Teodoro
name: Ramírez-Arpide, Félix Rafael
Publisher: name: Elsevier
Year: 2024
Subjects: sustainability
bio refinery
renewables
biomass
ethanol production
cactus
life cycle assessment
energy efficiency

description: Climate change, circular economy and Sustainable Development Goals are worldwide agendas. Using more renewables rather than fossil feedstocks in cleaner manufacturing is in line with those agendas. Holistic approaches are desired to care for water, energy, food and communities locally or globally. Ethanol is at the heart of the economy and sustainable ethanol production could help reaching Sustainable Development Goals. Sustainable biomass availability is problematic, and efforts continue to propose more biomass feedstocks with better impacts on water- food-energy and wellbeing. Promising arid plants, nopales aka prickly pear cactus, made breaking news when reaching the Alps while invading European countries due to climate change. Nopales are resilient to deserts and outcompete algae and other fermentable biomasses in many aspects. A novel sustainable biorefinery for ethanol production from nopales is desirable but its environmental impact and energy efficiency under realistic scenarios are unknown. We conducted experiments and sustainability assessments of realistic scenarios in a biorefinery producing ethanol from nopales with positive outcomes.
Europäische Mobilitätswoche
Creators: name: Kiso, Claudia
Publisher: name: My University
Year: 2017
Subjects: subject: Nachhaltige Mobilität
subject: Europäische Mobilitätswoche
subject: EMW
subject: Verkehr

description: Die EUROPÄISCHE MOBILITÄTSWOCHE (kurz EMW) ist eine Kampagne der Europäischen Kommission. Jedes Jahr vom 16. bis 22. September bietet sie Kommunen aus ganz Europa die perfekte Möglichkeit, ihren Bürgerinnen und Bürgern die komplette Bandbreite nachhaltiger Mobilität vor Ort näher zu bringen. Der neue Leitfaden zur EMW Deutschland fasst auf 28 Seiten alle wichtigen Informationen rund um die EMW zusammen und bietet durch viele Praxisbeispiele gleichzeitig Ideen für die eigene Teilnahme.
Occupational Exposure to Wood Dust and the Burden of Nasopharynx and Sinonasal Cancer in Canada
Creators: name: Mofidi, Amirabbas
name: Tompa, Emile
name: Kalcevich, Christina
name: McLeod, Chris B.
name: Lebeau, Martin
name: Song, Chaojie
name: Kim, Joanne
name: Demers, Paul A.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2022

description: Background: Millions of workers around the world are exposed to wood dust, as a by-product of woodworking. Nasopharynx cancers (NPCs) and sinonasal cancers (SNCs) are two cancers that can be caused by occupational exposure to wood dust, but there is little evidence regarding their burden in Canada. Objective: the aim of this study was to estimate the incidence and economic burden of newly diagnosed cases of NPC and SNC in 2011 in Canada, attributable to occupational exposures to wood dust. Methods: calculating the incidence of cancer attributable to occupational exposure involved three steps of defining relative risk, assessing the prevalence of exposure and population modelling. We estimated the lifetime costs of newly diagnosed NPC and SNC from the societal perspective. The three major cost categories that we considered were direct costs (healthcare costs, out-of-pocket costs, and informal caregiving costs), indirect costs (labour productivity/output costs, employer adjustment costs, and home production losses), and intangible costs (health-related quality of life losses). To generate an estimate of economic burden, we used secondary data from multiple sources and applied them to our computational model developed from an extensive literature review. Results: From approximately 1.3 million workers exposed to wood dust, we expected 28%, 43% and 29% were exposed to low, medium, and high levels, respectively. We estimated from 235 newly diagnosed cases of NPC and 245 newly diagnosed cases of SNC, 4.6% (11 cases) and 4.4% (11 cases) were attributed to occupational exposure to wood dust, respectively. Our estimates of the economic burden of occupational NPC and SNC were about CAD 5.4 million (CAD 496,311 per-case) and CAD 6.7 million (CAD 627,437 per-case), respectively. For NPC direct costs constituted approximately 20% of all costs, and indirect and intangible costs accounted for 55% and 25%, while for SNC the breakdown distribution were 16%, 42% and 42%, respectively. Conclusions: Our estimates highlighted the importance of occupational NPC and SNC amongst other occupational cancers, especially in countries with large wood-related industries. This paper also serves the information needs of policymakers who are seeking to make evidence-based decisions about occupational cancer prevention efforts.
The Effects of Selective Estrogenic Drugs in the Medial Amygdala on Male Rat Sexual Behavior
Creators: name: Ogaga-Mgbonyebi, Ejiroghene
Publisher: name: Georgia State University
Year: 2010

description: Male rat copulatory behavior is dependent on Testosterone (T) and its metabolites, estradiol (E2) and dihydrotestosterone (DHT). The estrogen receptor (ER) isoforms, ERà and ER?, exist in the medial Amygdala (MEA) and either receptor might mediate mating behavior. Therefore, the effects of selective estrogenic MEA implants: propyl pyrazole triol (PPT, ERà agonist), diarylpropionitrile (DPN, ER? agonist), and 1-methyl-4-phenyl pyridinium (MPP, ERà antagonist) were compared to E2 in maintaining sexual behavior. Four groups of male rats were castrated and administered DHT s.c. and bilateral MEA implants containing either cholesterol, E2, PPT or DPN. An additional group of gonadally intact male rats received bilateral MPP-MEA implants. The post-surgical trials showed a significant decrease in the mating behavior of groups that received cholesterol, PPT, or DPN-MEA implants. However, sexual behavior was maintained in male rats that received the E2 or MPP-MEA implants. These results suggest a differential response of the MEA to E2.
Study of Cellular Activities in Response to Metal-Induced Apoptosis in Saccharomyces Cerevisiae using FTIR
Creators: name: Koduru, Rupa
Publisher: name: Georgia State University
Year: 2011

description: Saccharomyces cerevisiae exhibits an apoptotic response upon exposure to toxic metals such as cadmium (Cd) and copper (Cu). Preliminary findings indicate that this response is dependent ?to some extent- on the presence of a fermentable carbon source, glucose. To investigate this dependency we monitored the apoptotic response to both metals in the presence and absence of glucose and have shown that glucose is absolutely necessary in order to induce apoptosis in yeast at least during the exposure to metal. We have also looked at the biochemical changes that are taking place in yeast when treated with Cd using Fourier Transform Infra-Red (FTIR) Spectroscopy. Our results suggest that there are definitive changes in cellular activities that are discernable at 1660-1640cm-1 (amide I), 1540-1510cm-1 (amide II) and 1140-1080cm-1(DNA absorption bands).
Perception of Color Vision In the Asian Small-Clawed Otter (Aonyx cinerea)
Creators: name: Svoke, Joseph
Publisher: name: Georgia State University
Year: 2011

description: Color vision can affect our assumptions of an animals? natural history. It can be determined by testing sensory or perception ability, which was employed here. Two Asian small-clawed otters (Aonyx cinerea), of opposite sexes, housed at ZooAtlanta, were trained via operant conditioning to discriminate stimuli within 7 tasks, primarily in a two-choice fashion. Varying shades of the colors blue, green and red were tested against varying greys, all which differed in intensity, served as the stimuli for the first 4 tasks. The remaining 3 tasks, the colors were tested against each other. The male reached criterion for the first 6 tasks, indicating an ability to discriminate the stimuli based on color. The female however participated only in 2, and could not achieve criterion as set, though there were indications of discrimination ability. Taken together with sensory work on two related otter species, Asian small-clawed otters possess color vision.
Mechanismen der Veränderung personalpolitischer Konstellationen : Ergebnisse von Simulationsstudien
Creators: name: Martin, Albert
Publisher: name: Medien- und Informationszentrum, Leuphana Universität Lüneburg
Year: 2020
Subjects: subject: Personalpolitik
subject: Simulationsstudie
classificationCode: 331
subject: 331 Arbeitsökonomie

description: Die vorliegende Simulationsstudie befasst sich mit der Etablierung und Veränderung der Personal-politik von Organisationen. Das den Simulationsrechnungen zugrunde liegende Modell beschreibt und erklärt den Einfluss personalpolitischer Kraftfelder auf die personalpolitischen Orientierungen von Organisationen. Berücksichtigt werden dabei die Rückwirkungen, die von der Personalpolitik auf die sie bestimmenden Kräfte ausgehen sowie die Beharrungskräfte, die einer einmal etablier-ten personalpolitischen Konstellation innewohnen. Und schließlich wird den Zufallsprozessen, die das personalpolitische Geschehen wesentlich mitbestimmen, die ihnen gebührende Beachtung ge-schenkt. Als theoretische Grundlage dient eine erweiterte und auf die Erklärung der Personalpolitik hin aus-gerichtete Version der Anreiz-Beitrags-Theorie, wonach sich, je nach den gegebenen Feldkraft-konstellationen, angepasste Sozialordnungen herausbilden. Die Elemente und Strukturen dieser Sozialordnungen sind aufeinander abgestimmt und stützen sich gegenseitig. Daraus entwickeln sich interne „Bindungskräfte“, die den verschiedenen Sozialordnungen ihre je eigene Stabilität ver-leihen. Die in dieser Theorie thematisierten Zusammenhänge werden in dem Simulationsmodell konkretisiert und in entsprechende Rechenvorschriften transformiert. Damit wird es möglich, den Ablauf und die Wirkung der von der Theorie unterstellten Mechanismen anhand von konkret be-nennbaren Vorgängen zu analysieren.
Systematic Studies of Kir and TRP Channel mRNAs in the Norepinephrenergic Neurons of the Locus Coeruleus
Creators: name: Tadepalli, Sakuntala Jyothirmayee
Publisher: name: Georgia State University
Year: 2011

description: Neurons in the Locus coeruleus (LC) play an important role in the central CO2 chemosensitivity. However, the molecular mechanisms for neuronal CO2 chemosensitivity remain unclear. To demonstrate the expression of pH/CO2 sensitive ion channels, we screened the inward rectifier K+ channels (Kir) and transient receptor protein (TRP) channels, as parallel studies in this lab suggested that certain Kir and TRP channels are involved in neuronal responses to high levels of CO2. Our results showed that several members of the Kir and TRP channel families were robustly expressed in the LC neurons at the mRNA level. Of particular interest are TRPC5, Kir4.1 and Kir5.1 channels that are all pH-sensitive. The rich expression of various pH-sensitive Kir and TRP channels suggests that these ion channels are likely to play a role in the chemosensitivity of LC neurons.
Modulation of NALP3 Inflammasome Genes by Estrogen
Creators: name: Chesnokov, Anton
Publisher: name: Georgia State University
Year: 2011

description: 
Immunity is known to be sexually dimorphic.  This dimorphism may be attributed to the action of different hormones.  Aluminum is a component of several vaccines and acts as an adjuvant of immunogenicity.  The activation of the Nalp3 inflammasome plays a role in aluminum?s adjuvancy.  Estrogen affects immune cells by regulating the expression of genes involved in immune-related mechanisms; such as the modulation of cytokine secretion.  We hypothesized that estrogen modulates the aluminum-induced secretion of IL-1? and IL-18.  Using an ex vivo mouse macrophage model this study examined: (i) the effects of estrogen on Nalp3 inflammasome genes expression and (ii) the estrogen receptor involved in the modulation of these genes.  Our results indicate that estrogen up-regulates Nalp3 gene expression via ERà/? heterodimerization, and caspase-1 activity may be indirectly modulated due to the up-regulation of SPI-6 via ER?.
The Reactive Carbonyl Methylglyoxal Suppresses Vascular KATP Channels by MRNA Destabilization
Creators: name: Konduru, Anuhya
Publisher: name: Georgia State University
Year: 2011

description: Diabetes mellitus is characterized by hyperglycemia, oxidative stress and excessive production of intermediary metabolites including methylglyoxal (MGO), a reactive carbonyl. MGO can readily interact with proteins, lipids and DNA, and cause an imbalance of the cellular antioxidant system leading to carbonyl stress. The effects of MGO can be devastating if the targeted molecules are responsible for the maintenance of membrane potentials and ionic homeostasis. Here we show that MGO disrupts the vascular isoform of ATP-sensitive K+ (KATP) channels by acting on the mRNAs of Kir6.1 and SUR2B subunits thereby regulating vascular tone. Our results show that the 3? untranslated region (UTR) of Kir6.1 mRNA and the coding region of SUR2B mRNA are targeted by MGO causing a disruption of vascular KATP channels. The destabilization of the mRNAs of KATP channel can in turn affect K+ homeostasis of vascular smooth muscles as well as vascular responses to circulating vasodilators and vasoconstrictors.
Quadrupolar and Dipolar Excitons in Bilayer 2$H$-MoSe$_2$
Creators: name: Feng, Shun
name: Campbell, Aidan J.
name: Francis, Bibi Mary
name: Baek, Hyeonjun
name: Taniguchi, Takashi
name: Watanabe, Kenji
name: Gerber, Iann C.
name: Gerardot, Brian D.
name: Brotons-Gisbert, Mauro
Publisher: name: arXiv
Year: 2025
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report the experimental observation of quadrupolar exciton states in the reflectance contrast spectrum of 2$H$-stacked bilayer MoSe$_2$. The application of a vertical electric field results in a quadratic energy redshift of these quadrupolar excitons, in contrast to the linear energy splitting observed in the coexisting dipolar excitons within the bilayer MoSe$_2$. We perform helicity-resolved reflectance contrast measurements to investigate the spin and valley configurations of the quadrupolar exciton states as a function of applied vertical electric and magnetic fields. Comparing our results with a phenomenological coupled-oscillator model indicates that the electric- and magnetic-field dependence of the quadrupolar exciton states can be attributed to the intravalley and intervalley hybridization of spin-triplet interlayer excitons with opposite permanent dipole moments, mediated by interlayer hole tunneling. These results position naturally stacked MoSe$_2$ bilayers as a promising platform to explore electric-field-tunable many-body exciton phenomena.