cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene
Creators: name: Dai, Feng
name: Diatchenko, Luda
name: Gibson, Dustin G.
name: Langeslag, Michiel
name: Sarangi, Rinku
name: Pospisilik, J. Andrew
name: Thomas, Winston
name: Maixner, William
name: Cronin, Shane J.F.
name: Dan, Debasis
name: Xia, Cui ping
name: Wolz, Susanne
name: Neely, G. Gregory
name: Gupta, Vaijayanti
name: Ly, Cindy V.
name: Alenius, Mattias
name: Angjeli, Belinda
name: Dietzl, Georg
name: Novatchkova, Maria
name: Meixner, Arabella
name: Heindl-Erdmann, Cornelia
name: Bellen, Hugo J.
name: Zoranovic, Tamara
name: Hess, Andreas
name: Woolf, Clifford J.
name: Belfer, Inna
name: Rosenzweig, Mark
name: Garrity, Paul A.
name: Subramaniam, Sai
name: Truong, Darwin
name: Penninger, Josef M.
name: Kreitz, Silke
name: Kress, Michaela
name: Arora, Suchir
name: Smith, Shad B.
name: Brune, Kay
name: Griffin, Robert S.
name: Goulas, Spyros
name: Keene, Alex C.
name: Schramek, Daniel
name: Amann, Sabina
name: Costigan, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Worldwide, acute and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knock-down in Drosophila, we report a global screen for an innate behavior and identify hundreds of novel genes implicated in heat nociception, including the α2δ-family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (α2δ3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, α2δ3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in α2δ3 mutant mice revealed impaired transmission of thermal pain evoked signals from the thalamus to higher order pain centers. Intriguingly, in α2δ3 mutant mice thermal pain and tactile stimulation triggered strong cross-activation or synesthesia of brain regions involved in vision, olfaction, and hearing.
Schwinger pair production with ultracold atoms
Creators: name: Kasper, V.
name: Hebenstreit, F.
name: Oberthaler, M.
name: Berges, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider a system of ultracold atoms in an optical lattice as a quantum simulator for electron-positron pair production in quantum electrodynamics (QED). For a setup in one spatial dimension, we investigate the nonequilibrium phenomenon of pair production including the backreaction leading to plasma oscillations. Unlike previous investigations on quantum link models, we focus on the infinite-dimensional Hilbert space of QED and show that it may be well approximated by experiments employing Bose-Einstein condensates interacting with fermionic atoms. The calculations based on functional integral techniques give a unique access to the physical parameters required to realize the QED phenomena in a cold atom experiment. In particular, we use our approach to consider quantum link models in a yet unexplored parameter regime and give bounds for their ability to capture essential features of the physics. The results suggest a paradigmatic change towards realizations using coherent many-body states rather than single atoms for quantum simulations of high-energy particle physics phenomena.
description: 5 pages, 4 figures, PLB version
title: Role of imaging in the diagnosis and monitoring of paediatric Langerhans Cell Histiocytosis
Creators: name: ben abdeladhim, yasmine
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Musculoskeletal bone
subject: Paediatric
subject: CT
subject: MR
subject: Ultrasound
subject: Education
subject: Cirrhosis
subject: Cysts
subject: Endocrine disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The aim of this presentation is to recognize the aspects that suggest Langerhans Cell Histiocytosis (LCH) in skeletal and extra skeletal localizations in pediatric population and to illustrate some cases of LCH that are followed in our...
title: Retrograde urethrocystography interest in secondary vesicoureteral reflux evaluation in adults. About 28 cases.
Creators: name: NDAYISHIMIYE, NDAYISHIMIYE
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Urinary Tract / Bladder
subject: Conventional radiography
subject: Contrast agent-other
subject: Obstruction / Occlusion

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Vesicoureteral reflux (VUR) is defined as the retrograde flow of urine from the bladder to the kidneys. It may be divided into primary and secondary types, with primary VUR being the predominant process. Primary VUR occurs in the absence of any...
title: Spleen elastography as а noninvasive method for diagnostics of esophageal varices in patients with cirrhosis
Creators: name: Doykova, Katya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Gastrointestinal tract
subject: Elastography
subject: Endoscopy
subject: Cirrhosis
subject: Haemorrhage
subject: Varices

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Chronic liver disease leads to portal hypertension and hepatic failure, ascites, esophageal varices /EV/ and encephalopathy. [1, 2, 3] Gastro-esophageal varices are a major complication that occurs in 30-70% of the patients with liver cirrhosis and...
title: An integrating of clinical, pathological, and radiomic approach to predict the microsatellite instability in rectal carcinoma
Creators: name: Ma, Yanqing
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Colon
subject: CT
subject: Comparative studies
subject: Computer Applications-Detection, diagnosis
subject: Efficacy studies
subject: Cancer
subject: Pathology
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To develop an integrative model with clinical, pathological, and radiomic characteristics to predict the status of microsatellite instability (MSI) in rectal carcinoma...
title: Aberrant resting functional brain network topology in cirrhosis with and without hepatic encephalopathy
Creators: name: zhou, jiamin
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR-Functional imaging
subject: Outcomes analysis
subject: Cirrhosis

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: In this study, the graph theory method was used to construct the brain functional network, and then the network topology properties were calculated to compare the changes of the brain network characteristics in the process of liver cirrhosis...
Metal monoxide abundances as a function of the C/O ratio
Creators: name: Meijer, Gerard
name: von Helden, Gert
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The diatomic metal monoxides whose optical spectra define the classification of stars on the asymptotic giant branch (AGB), that is, TiO, YO, ZrO, and LaO, have the unusual property that their ionization energy is below their dissociation limit. The cations of these metal monoxides can be efficiently produced via associative ionization of their constituent ground state atoms and are long-lived. We present a simple model that can explain the observed relative abundance of these metal oxides as a function of the C/O ratio.
(401707) Barbara Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ABP1 Mediates Auxin Inhibition of Clathrin-Dependent Endocytosis in Arabidopsis
Creators: name: Kleine-Vehn, Jürgen
name: Barbez, Elke
name: Zažímalová, Eva
name: Baster, Pawel
name: Simon, Sibu
name: Dhonukshe, Pankaj
name: Čovanová, Milada
name: Hayashi, Kenichiro
name: Friml, Jiří
name: Bednarek, Sebastian Y.
name: Zhang, Jing
name: Paciorek, Tomasz
name: Aniento, Fernando
name: Jones, Alan M.
name: Luschnig, Christian
name: Robert, Stéphanie
name: Sauer, Michael
name: Yang, Zhenbiao
name: Vanneste, Steffen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Spatial distribution of the plant hormone auxin regulates multiple aspects of plant development. These self-regulating auxin gradients are established by the action of PIN auxin transporters, whose activity is regulated by their constitutive cycling between the plasma membrane and endosomes. Here, we show that auxin signaling by the auxin receptor AUXIN-BINDING PROTEIN 1 (ABP1) inhibits the clathrin-mediated internalization of PIN proteins. ABP1 acts as a positive factor in clathrin recruitment to the plasma membrane, thereby promoting endocytosis. Auxin binding to ABP1 interferes with this action and leads tothe inhibition of clathrin-mediated endocytosis. Our study demonstrates that ABP1 mediates a nontranscriptional auxin signaling that regulates the evolutionarily conserved process of clathrin-mediated endocytosis and suggests that this signaling may be essential for the developmentally important feedback of auxin on its own transport.
01 Using tablets in a prekindergarten classroom to foster phonological awareness
Creators: name: Shifflet, Rena
name: Mattoon, Cassandra
name: Bates, Alan
Publisher: name: Monash University
Year: 2020
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences

description: Today’s young children are exposed to a variety of digital technologies in their home and school environments. While the presence of these technologies is increasing in US prekindergarten classrooms, teachers must critically analyze the role these tools will play in the quest to provide early learners with developmentally appropriate practice. The benefit of using tablet-based applications, compared to traditional concrete materials, to teach phonological awareness skills is the focus of this study conducted in 2014. The sample consisted of 27 four- and five-year-old children, who attended a half-day early childhood program, 5 days a week, in a Midwestern university laboratory school in the US. Children participated in similar small-group instruction once or twice a week for 4 months, from September to December, targeting phonological awareness skills. A comparison was made between those who were instructed using the traditional materials and those who used tablet-based applications. Both groups were found to make progress toward mastering the tested skills. There was no significant difference between the two groups’ acquisition of these skills. Students were able to achieve targeted phonological awareness skills using either method of instruction.
(401708) David Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Evaluation of retinoblastoma with magnetic resonance imaging. What the radiologist needs to know.
Creators: name: Constenla, Diego
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Eyes
subject: Head and neck
subject: Paediatric
subject: MR
subject: Education
subject: Cancer
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To recognize the main imaging characteristics of retinoblastomas in MRI. To know and recognize the MRI findings in retinoblastoma that are predictors of local invasion and distant metastasis. To utilize 3D illustrations as a tool in radiological...
Quantum battery supercharging via counter-diabatic dynamics
Creators: name: de Moraes, L. F. C.
name: Duriez, Alan C.
name: Saguia, A.
name: Santos, Alan C.
name: Sarandy, Marcelo S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce a counter-diabatic approach for deriving Hamiltonians modeling superchargable quantum batteries (QBs). A necessary requirement for the supercharging process is the existence of multipartite interactions among the cells of the battery. Remarkably, this condition may be insufficient no matter the number of multipartite terms in the Hamiltonian. We analytically illustrate this kind of insufficiency through a model of QB based on the adiabatic version for the Grover search problem. On the other hand, we provide QB supercharging with just a mild number of global connections in the system. To this aim, we consider a spin-$1/2$ chain with $n$ sites in the presence of Ising multipartite interactions. We then show that, by considering the validity of the adiabatic approximation and by adding $n$ terms of $(n-1)$-site interactions, we can achieve a Hamiltonian exhibiting maximum QB power, with respect to a normalized evolution time, growing quadratically with $n$. Therefore, supercharging can be achieved by $O(n)$ terms of multipartite connections. The time constraint required by the adiabatic approximation can be surpassed by considering a counter-diabatic expansion in terms of the gauge potential for the original Hamiltonian, with a limited $O(n)$ many-body interaction terms assured via a Floquet approach for the counter-diabatic implementation.
description: 13 pages and 3 figures. Last version also available as Open Access from Quantum Science and Technology website
Completing the picture of the Roper resonance
Creators: name: Segovia, Jorge
name: El-Bennich, Bruno
name: Rojas, Eduardo
name: Cloet, Ian C.
name: Roberts, Craig D.
name: Xu, Shu-Sheng
name: Zong, Hong-Shi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We employ a continuum approach to the three valence-quark bound-state problem in relativistic quantum field theory to predict a range of properties of the proton's radial excitation and thereby unify them with those of numerous other hadrons. Our analysis indicates that the nucleon's first radial excitation is the Roper resonance. It consists of a core of three dressed-quarks, which expresses its valence-quark content and whose charge radius is 80% larger than the proton analogue. That core is complemented by a meson cloud, which reduces the observed Roper mass by roughly 20%. The meson cloud materially affects long-wavelength characteristics of the Roper electroproduction amplitudes but the quark core is revealed to probes with $Q^2 \gtrsim 3 m_N^2$.
description: 6 pages, 3 figures
Prospects for Measurement of the Neutrino Mass Hierarchy
Creators: name: Patterson, R. B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The unknown neutrino mass hierarchy -- whether the $ν_3$ mass eigenstate is the heaviest or the lightest -- represents a major gap in our knowledge of neutrino properties. Determining the hierarchy is a critical step toward further precision measurements in the neutrino sector. The hierarchy is also central to interpreting the next generation of neutrinoless double beta decay results, plays a role in numerous cosmological and astrophysical questions, and serves as a powerful model discriminant for theories of neutrino mass generation and unification. Various current and planned experiments claim sensitivity for establishing the neutrino mass hierarchy. We review the most promising of these here, paying special attention to points of concern and consolidating the projected sensitivities into an outlook for the years ahead.
description: Uploading final version. 13 pages, 7 figures
Cell Surface- and Rho GTPase-Based Auxin Signaling Controls Cellular Interdigitation in Arabidopsis
Creators: name: Fu, Ying
name: Friml, Jiří
name: Yang, Zhenbiao
name: Xu, Tongda
name: Chen, Jin Gui
name: Nagawa, Shingo
name: Perrot-Rechenmann, Catherine
name: Wu, Ming Jing
name: Wen, Mingzhang
name: Jones, Alan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Auxin is a multi-functional hormone essential for plant development and pattern formation. A nuclear auxin signaling system controlling auxin-induced gene expression is well established, but cytoplasmic auxin signaling as in its coordination of cell polarization is unexplored. We found a cytoplasmic auxin signaling mechanism that modulates the interdigitated growth of Arabidopsis leaf epidermal pavement cells (PCs), which develop interdigitated lobes and indentations to form a puzzle-piece shape in a two-dimensional plane. PC interdigitation is compromised in leaves deficient in either auxin biosynthesis or its export mediated by PINFORMED 1 localized at the lobe tip. Auxin coordinately activates two Rho GTPases, ROP2 and ROP6, which promote the formation of complementary lobes and indentations, respectively. Activation of these ROPs by auxin occurs within 30 seconds and depends on AUXIN-BINDING PROTEIN 1. These findings reveal Rho GTPase-based novel auxin signaling mechanisms, which modulate the spatial coordination of cell expansion across a field of cells.
Benford's Law Applies To Online Social Networks
Creators: name: Golbeck, Jennifer
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Benford's Law states that the frequency of first digits of numbers in naturally occurring systems is not evenly distributed. Numbers beginning with a 1 occur roughly 30\% of the time, and are six times more common than numbers beginning with a 9. We show that Benford's Law applies to social and behavioral features of users in online social networks. We consider social data from five major social networks: Facebook, Twitter, Google Plus, Pinterest, and Live Journal. We show that the distribution of first significant digits of friend and follower counts for users in these systems follow Benford's Law. The same holds for the number of posts users make. We extend this to egocentric networks, showing that friend counts among the people in an individual's social network also follow the expected distribution. We discuss how this can be used to detect suspicious or fraudulent activity online and to validate datasets.
description: 9 pages, 2 figures
02 Interactive imagination supports toddlers’ emotion regulation: A cultural-historical case study in a Chinese-American family
Creators: name: Feiyan Chen
Publisher: name: Monash University
Year: 2020
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences

description: Emotion regulation—as a vital part of children’s development, school readiness, and academic success—begins to develop in infancy and toddler time. Much of the research on toddler emotion regulation are correlational studies in laboratory settings. Little attention has been directed to toddlers’ emotion regulation in everyday naturalistic contexts. Drawing upon Vygotsky’s cultural-historical approach, the current case study sought to examine how everyday parent–toddler interactions assist the toddler’s emotion regulation in emotionally charged situations in a Chinese-American family home. Findings showed that the strategy of interactive imagination supported the toddler’s emotion regulation in emotionally charged situations. However, parents did not often apply this method. It is argued that interactive imagination is an essential tool to be used in everyday parent–toddler interactions for emotion regulation. Recommendations for practice are discussed.
MATLAB as a Service on INFN Cloud
Creators: name: Fornari, Federico
name: Pellegrino, Carmelo
name: Salomoni, Davide
name: Gasparetto, Jacopo
name: Corvo, Marco
name: Vistoli, Maria Cristina
Publisher: name: Zenodo
Year: 2023

description: MATLAB is a numerical computation software developed and distributed by MathWorks that enables a user to perform advanced mathematical and scientific calculations and can be used to solve problems in mathematics, physics, engineering, and life sciences. In particular, it offers a wide range of functions, supporting computation on GPUs, manipulation and simplification of mathematical equations, but also the design of electronic and control systems. It is therefore a framework that can satisfy various use cases required by the experiments and projects that collaborate with INFN. For this reason, INFN has decided to invest funds for the purchase of unlimited MATLAB licenses. Jupyter is an open-source web-based interactive computing environment that allows users to write and run code in Python, R, Julia, and many other programming languages, as well as create interactive visualizations and graphs. It is therefore a service that lends itself very well to a cloud-type environment and is currently widely used by the communities of users who have access to INFN Cloud. MATLAB can be integrated with Jupyter Notebook to run MATLAB code within the Jupyter interface, or through MATLAB's native web interface. A first but effective development has recently been carried out to obtain the instantiation of MATLAB through the Jupyter services and the storage solutions offered by INFN Cloud. This contribution shows how a user can use the service in PaaS mode through INFN Cloud and was presented in the ICT Services track of INFN CCR Workshop 2023.
title: The association between adipose tissue and abdominal aortic aneurysm progression after endovascular aneurysm repair
Creators: name: Hu, Ge
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Arteries / Aorta
subject: Interventional vascular
subject: CT-Angiography
subject: Angioscopy
subject: Aneurysms

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Endovascular aneurysm repair (EVAR) is the preferable choice for patients with abdominal aortic aneurysm (AAA). Although EVAR is safer and minimally invasive compared to traditional open repair, there is still a potential risk of enlargement or...
MicroMagnetic.jl: A Julia package for micromagnetic and atomistic simulations with GPU support
Creators: name: Wang, Weiwei
name: Lyu, Boyao
name: Kong, Lingyao
name: Fangohr, Hans
name: Du, Haifeng
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: MicroMagnetic.jl is an open-source Julia package for micromagnetic and atomistic simulations. Using the features of the Julia programming language, MicroMagnetic.jl supports CPU and various GPU platforms, including NVIDIA, AMD, Intel, and Apple GPUs. Moreover, MicroMagnetic.jl supports Monte Carlo simulations for atomistic models and implements the Nudged-Elastic-Band method for energy barrier computations. With built-in support for double and single precision modes and a design allowing easy extensibility to add new features, MicroMagnetic.jl provides a versatile toolset for researchers in micromagnetics and atomistic simulations.
TGF-β Signaling Specifies Axons during Brain Development
Creators: name: Yi, Jason J.
name: Polleux, Franck
name: Ehlers, Michael D.
name: Barnes, Anthony P.
name: Hand, Randal
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the extracellular factor(s) that initiate neuronal polarity in vivo is unknown. Here, we report that transforming growth factor-β (TGF-β) initiates signaling pathways both in vivo and in vitro to fate naïve neurites into axons. Neocortical neurons lacking the type II TGF-β receptor (TβR2) fail to initiate axons during development. Exogenous TGF-β is sufficient to direct the rapid growth and differentiation of an axon, and genetic enhancement of receptor activity promotes the formation of multiple axons. Finally, we show that the bulk of these TGF-β-dependent events are mediated by site-specific phosphorylation of Par6. These results define an extrinsic cue for neuronal polarity in vivo that patterns neural circuits in the developing brain.
Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
Creators: name: Zhang, Lihong
name: Li, Ying
name: Jin, Minzhi
name: Yu, Jia
name: Ma, Dawei
name: Xu, Lihua
name: Kim, Minsu
name: Zhu, Zhimin
name: Hao, Yan
name: Ke, Hengming
name: Choi, Augustine
name: Zhang, Tao
name: Wang, Huanchen
name: Li, Yanxia
name: Norberg, Helin Vakifahmetoglu
name: Yuan, Junying
name: Cai, Yu
name: Xia, Hongguang
name: Liu, Junli
name: Furuya, Tsuyoshi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named “spautin-1” for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Beclin1 is a tumor suppressor and frequently monoallelically lost in human cancers. Interestingly, Beclin1 also controls the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities. Since USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Our study provides a molecular mechanism involving protein deubiquitination that connects two important tumor suppressors, p53 and Beclin1, and a potent small molecule inhibitor of autophagy as a possible lead compound for developing anticancer drugs.
Efficient PDE constrained shape optimization based on Steklov-Poincaré type metrics
Creators: name: Schulz, Volker
name: Siebenborn, Martin
name: Welker, Kathrin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: Recent progress in PDE constrained optimization on shape manifolds is based on the Hadamard form of shape derivatives, i.e., in the form of integrals at the boundary of the shape under investigation, as well as on intrinsic shape metrics. From a numerical point of view, domain integral forms of shape derivatives seem promising, which rather require an outer metric on the domain surrounding the shape boundary. This paper tries to harmonize both points of view by employing a Steklov-Poincaré type intrinsic metric, which is derived from an outer metric. Based on this metric, efficient shape optimization algorithms are proposed, which also reduce the analytical labor, so far involved in the derivation of shape derivatives.
MPEC 2023-T235 : 2023 TD10
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 TD10

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
(401709) Nina Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Investigation on the effectiveness of artificial intelligence-aided diagnostic systems as a second reader to assist radiologist in the prediction of hematoma expansion (HE)
Creators: name: Yuli, Wang
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CT
subject: CAD
subject: Haemorrhage

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To investigate whether the prediction of hematoma expansion (HE) by AI as a second-reader would improve the prediction capability of...
Endocrine Regulation of Male Fertility by the Skeleton
Creators: name: Suarez, Susan
name: Sumara, Grzegorz
name: Hermo, Louis
name: Smith, Charles E.
name: Sumara, Olga
name: Roth, Bryan L.
name: Chang, Haixin
name: Oury, Franck
name: Ducy, Patricia
name: Karsenty, Gerard
name: Ferron, Mathieu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Although the endocrine capacity of bone is widely recognized, interactions between bone and the reproductive system have until now focused on the gonads as a regulator of bone remodeling. We now show that in males, bone acts as a regulator of fertility. Using co-culture assays, we demonstrate that osteoblasts are able to induce testosterone production by the testes, while they fail to influence estrogen production by the ovaries. Analyses of cell-specific loss- and gain-of-function models reveal that the osteoblast-derived hormone osteocalcin performs this endocrine function. By binding to a G-protein coupled receptor expressed in the Leydig cells of the testes, osteocalcin regulates in a CREB-dependent manner the expression of enzymes required for testosterone synthesis, promoting germ cell survival. This study expands the physiological repertoire of osteocalcin, and provides the first evidence that the skeleton is an endocrine regulator of reproduction.
Preserving and Increasing Symmetries of Polyhedral Maps
Creators: name: Brinkmann, Gunnar
name: Buccoliero, Fabio
name: Camp, Heidi Van den
Publisher: name: arXiv
Year: 2024
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C10, 52B15, 05C76, 05C92

description: In this article we investigate the question which local symmetry preserving operations can not only preserve, but also increase the symmetry of a polyhedral map. Often operations that can increase symmetry, can nevertheless not do so for polyhedral maps of every genus. So for maps that can increase symmetry, we also investigate for which genera they can do so. We give complete answers for operations with inflation factor at most 6 (that is: that increase the number of edges by a factor of at most 6) and for the chemically relevant Goldberg-Coxeter operations and the leapfrog operation.
Sharing invasive alien species data: why and how?
Creators: name: Reyserhove, Lien
name: Desmet, Peter
name: Oldoni, Damiano
Publisher: name: Zenodo
Year: 2022
Subjects: open data
GBIF
open source
Darwin Core
GDPR
LIFE RIPARIAS

description: Description This document describes in the context of the LIFE RIPARIAS project: the benefits of making biodiversity (IAS) data open why we use GBIF as a data infrastructure and aggregator what to do with personal and non-validated data the minimal information needed from data providers to allow an efficient harmonisation of data sources Files Sharing invasive alien species data_why and how.pdf
description: This work was funded under the European Commission LIFE programme (LIFE19 NAT/BE/000953).
Unified explanation of the $eejj$, diboson and dijet resonances at the LHC
Creators: name: Dev, P. S. Bhupal
name: Mohapatra, R. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We show that the excess events observed in a number of recent LHC resonance searches can be simultaneously explained within a minimal non-supersymmetric left-right inverse seesaw model for neutrino masses with $W_R$ mass around 1.9 TeV. We further show that the minimal TeV-scale particle content that leads to gauge coupling unification in this model predicts $g_R\simeq 0.51$ at the TeV-scale. The extra color-singlet, $SU(2)$-triplet fermions required for unification can be interpreted as the Dark Matter of the Universe. Future measurements of the ratio of same-sign to opposite-sign dilepton events can provide a way to distinguish this scenario from the canonical cases of type-I and inverse seesaw, i.e. provide a measure of the relative magnitudes of the Dirac and Majorana masses of the right-handed neutrinos in the $SU(2)_R$-doublet of the left-right symmetric model.
description: 7 pages, 2 figures; minor changes; version to appear in PRL
A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing
Creators: name: Hinnebusch, Alan G.
name: Yuan, Peihua
name: Herman, Paul K.
name: Dewar, Brian J.
name: Gaur, Naseem A.
name: Wolpert, Max
name: Mousley, Carl J.
name: Nile, Aaron H.
name: Deminoff, Stephen J.
name: Bankaitis, Vytas A.
name: Trettin, Kyle D.
name: MacDonald, Jeffrey M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Kes1, and other oxysterol binding protein (OSBP) superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal systems. We demonstrate that Kes1 represents a sterol-regulated antagonist of TGN/endosomal phosphatidylinositol-4-phosphate signaling. This regulation modulates TOR activation by amino acids, and dampens gene expression driven by Gcn4; the primary transcriptional activator of the general amino acid control regulon. Kes1-mediated repression of Gcn4 transcription factor activity is characterized by nonproductive Gcn4 binding to its target sequences, involves TGN/endosome-derived sphingolipid signaling, and requires activity of the cyclin-dependent kinase 8 (CDK8) module of the enigmatic ‘large Mediator’ complex. These data describe a pathway by which Kes1 integrates lipid metabolism with TORC1 signaling and nitrogen sensing.
Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis
Creators: name: Bear, James E.
name: Haynes, Elizabeth M.
name: Gomez, Shawn M.
name: Griffith, Jack D.
name: Wu, Congying
name: Asokan, Sreeja B.
name: Sharpless, Norman E.
name: Berginski, Matthew E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Lamellipodia are sheet-like, leading edge protrusions in firmly adherent cells that contain Arp2/3-generated dendritic actin networks. Although lamellipodia are widely believed to be critical for directional cell motility, this notion has not been rigorously tested. Using fibroblasts derived from Ink4a/Arf-deficient mice, we generated a stable line depleted of Arp2/3 complex that lacks lamellipodia. This line shows defective random cell motility and relies on a filopodia-based protrusion system. Utilizing a microfluidic gradient generation system, we tested the role of Arp2/3 complex and lamellipodia in directional cell migration. Surprisingly, Arp2/3-depleted cells respond normally to shallow gradients of PDGF indicating that lamellipodia are not required for fibroblast chemotaxis. Conversely, these cells cannot respond to a surface-bound gradient of extracellular matrix (haptotaxis). Consistent with this finding, cells depleted of Arp2/3 fail to globally align focal adhesions suggesting that one principle function of lamellipodia is to organize cell-matrix adhesions in a spatially coherent manner.
title: Automated volumetry of the uterus on T2-weighted MRI in patients with uterine fibroids
Creators: name: Theis, Maike
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: Genital / Reproductive system female
subject: Pelvis
subject: MR
subject: Computer Applications-3D
subject: Segmentation
subject: Hyperplasia / Hypertrophy

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Uterine fibroids, also known as leiomyomas, are the most common benign pelvic tumors in women. In symptomatic leiomyomas, affected patients often complain of heavy menstrual bleeding, a feeling of pressure in the pelvic area or increased urinary...
Ultrahigh-energy neutrino searches using next-generation gravitational wave detectors at radio neutrino detectors: GRAND, IceCube-Gen2 Radio, and RNO-G
Creators: name: Mukhopadhyay, Mainak
name: Kotera, Kumiko
name: Wissel, Stephanie
name: Murase, Kohta
name: Kimura, Shigeo S.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Binary neutron star (BNS) mergers can be sources of ultrahigh-energy (UHE) cosmic rays and potential emitters of UHE neutrinos. The upcoming and current radio neutrino detectors like the Giant Radio Array for Neutrino Detection (GRAND), IceCube-Gen2 Radio, and the Radio Neutrino Observatory in Greenland (RNO-G) are projected to reach the required sensitivities to search for these neutrinos. In particular, in conjunction with the next-generation of gravitational wave (GW) detectors like Cosmic Explorer (CE) and Einstein Telescope (ET), GW-triggered stacking searches can be performed with the UHE neutrino detectors. In this work, we explore the prospects of such searches by implementing in our analysis an upper distance limit based on the sky-localization capabilities of the GW detectors from which meaningful triggers can be collected. We find that if each GW burst is associated with a total isotropic-equivalent energy of $\sim 10^{50} - 10^{51}$ erg emitted in UHE neutrinos, along with a corresponding beaming fraction of $1$\%, GRAND and IceCube-Gen2 Radio have a large probability ($\sim 99$\%) to detect a coincident neutrino event using the joint combination of CE+ET in a timescale of less than 15 years of operation for our fiducial choice of parameters. In case of nondetections, the parameter spaces can be constrained at $3σ$ level in similar timescales of operation. We also highlight and discuss the prospects of such joint radio neutrino detector network, their importance, and their role in facilitating synergic GW and neutrino observations in the next era of multimessenger astrophysics.
description: 18 pages, 6 figures
Contamination of stellar-kinematic samples and uncertainty about dark matter annihilation profiles in ultrafaint dwarf galaxies: the example of Segue I
Creators: name: Bonnivard, V.
name: Maurin, D.
name: Walker, M. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The expected gamma-ray flux coming from dark matter annihilation in dwarf spheroidal (dSph) galaxies depends on the so-called `J-factor', the integral of the squared dark matter density along the line-of-sight. We examine the degree to which estimates of J are sensitive to contamination (by foreground Milky Way stars and stellar streams) of the stellar-kinematic samples that are used to infer dark matter densities in `ultrafaint' dSphs. Applying standard kinematic analyses to hundreds of mock data sets that include varying levels of contamination, we find that mis-classified contaminants can cause J-factors to be overestimated by orders of magnitude. Stellar-kinematic data sets for which we obtain such biased estimates tend 1) to include relatively large fractions of stars with ambiguous membership status, and 2) to give estimates for J that are sensitive to specific choices about how to weight and/or to exclude stars with ambiguous status. Comparing publicly-available stellar-kinematic samples for the nearby dSphs Reticulum~II and Segue~I, we find that only the latter displays both of these characteristics. Estimates of Segue~I's J-factor should therefore be regarded with a larger degree of caution when planning and interpreting gamma-ray observations. Moreover, robust interpretations regarding dark matter annihilation in dSph galaxies in general will require explicit examination of how interlopers might affect the inferred dark matter density profile.
description: 12 pages, 8 figures. New appendix A (joint light/dark matter likelihood), results unchanged. Match accepted MNRAS version
CP Violation of Baryon Decays with $Nπ$ Scatterings
Creators: name: Wang, Jian-Peng
name: Yu, Fu-Sheng
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: There is a long-standing puzzle that the CP violation (CPV) in the baryon systems has never been well established in experiments, while the CPV of mesons have been observed by decades. In this paper, we propose that the CPV of baryon decays can be generated with the rescatterings of a nucleon and a pion into some final states, i.e. $Nπ\to Nπ$ or $Nππ$. Benefited by the fruitful data of $Nπ$ scatterings, we can model-independently analyse the strong phases of $b$-baryon decays using the partial wave amplitudes of $Nπ$ scatterings. Avoiding the most difficult problem of non-perturbative dynamics, it makes a great advantage to predict the CPV of baryon decays with a relatively reliable understanding of the decay dynamics. We study the processes of $Λ_b^0\to (pπ^+π^-)h^-$ and $(pπ^0)h^-$ with $h=π$ or $K$. It is found that the global CPV of the above processes in the invariant mass regions of $Nπ$ scatterings are at the order of several percent. More importantly, the local CPV in some regions of the Dalitz plots can reach the order of $10\%$, or be even larger. Considering the predicted results and the experimental data samples, we strong suggest to measure the CPV of $Λ_b^0\to (pπ^+π^-)K^-$, which has a large possibility to achieve the first observation of CPV in the baryon system.
description: 10 pages, 5 figures, 1 table. Updated to match the published version
Hinweise zu Erkennung, Diagnostik und Therapie von Patienten mit COVID-19
Creators: name: Ständiger Arbeitskreis Der Kompetenz- Und Behandlungszentren Für Krankheiten Durch Hochpathogene Erreger
Publisher: name: Robert Koch-Institut
Year: 2020
Subjects: subject: 610 Medizin und Gesundheit

description: Die Pandemie durch das neue Coronavirus SARS-CoV-2 stellt unser gesamtes Gesundheitssystem vor große Herausforderungen. Trotz der globalen Forschungsanstrengungen bestehen weiterhin erhebliche Wissenslücken in Bezug auf die durch das Virus verursachte Erkrankung COVID-19. Die Evidenzgrundlage verändert sich kontinuierlich, sodass eine regelmäßige Aktualisierung der Inhalte dieses Dokumentes sowie die ergänzenden verlinkten Quellen erfolgt. Daher sollte dieses Dokument auch nur in seiner jeweils letzten Fassung Anwendung finden. Ziel des Dokuments ist es, Hinweise zum Umgang mit COVID-19-Patienten zu geben und vorhandene weiterführende Dokumente zur besseren Übersicht zu bündeln.
Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Creators: name: Jordan, Nicole Vincent
name: Granger, Deborah A.
name: Zawistowski, Jon S.
name: Darr, David B.
name: Midland, Alicia A.
name: Usary, Jerry
name: Zhou, Bing
name: Kuan, Pei Fen
name: Frye, Stephen V.
name: Sharpless, Norman E.
name: Jin, Jian
name: He, Xiaping
name: Earp, H. Shelton
name: Major, Ben
name: Perou, Charles M.
name: Johnson, Nancy L.
name: Graves, Lee M.
name: Johnson, Gary L.
name: Duncan, James S.
name: Nakamura, Kazuhiro
name: Kim, William Y.
name: Smalley, David M.
name: Gomez, Shawn M.
name: Whittle, Martin C.
name: Abell, Amy N.
name: Hoadley, Katherine A.
name: Chen, Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome activity in response to MEK inhibition in triple negative breast cancer (TNBC) cells and genetically engineered mice (GEMMs). MEK inhibition caused acute ERK activity loss, resulting in rapid c-Myc degradation that induced expression and activation of several receptor tyrosine kinases (RTKs). RNAi knockdown of ERK or c-Myc mimicked RTK induction by MEK inhibitors, whereas prevention of proteasomal c-Myc degradation blocked kinome reprogramming. MEK inhibitor-induced RTK stimulation overcame MEK2 but not MEK1 inhibition, reactivating ERK and producing drug resistance. The C3Tag GEMM for TNBC similarly induced RTKs in response to MEK inhibition. The inhibitor-induced RTK profile suggested a kinase inhibitor combination therapy that produced GEMM tumor apoptosis and regression where single agents were ineffective. This approach defines mechanisms of drug resistance, allowing rational design of combination therapies for cancer.