cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Two Applications of Boolean Valued Analysis
Creators: name: Kusraev, A. G.
name: Kutateladze, S. S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46B42, 46S20

description: The paper contains two main results that are obtained by Boolean valued analysis. The first asserts that a universally complete vector lattice without locally one-dimensional bands can be decomposed into a direct sum of two vector sublattices that are laterally complete and invariant under all band projections and there exists a band preserving linear isomorphism of each of these sublattices to the original lattice. The second result establishes a counterpart of the Ando Theorem on the joint characterization of $A\!L^p$ and $c_0$ for the class of cyclic Banach lattices, using the Boolean valued transfer for injective Banach lattices.
description: This a preprint of the work accepted for publication in Siberian Mathematical Journal; $\copyright$ 2019, Pleiades Publishing Ltd. http://pleiades.online/
Mode of Delivery and the Effectiveness of Foreign Aid: The Example of Missionary Work
Creators: name: Mangeloja, Esa
name: Ovaska, Tomi
name: Mangeloja, Esa
name: Ovaska, Tomi
Publisher: name: Unknown
Year: 2010
Subjects: subject: International Development
subject: International Relations/Trade
subject: Development
subject: foreign aid
subject: grass-roots aid
subject: missionary work

description: Conventional development aid, typically a service from government to government, has been a relatively poor determinant of economic growth or human development in developing countries. In this paper we test whether a distinctly grass-roots delivery mode, as is the case with missionary work, leads to a more effective dispersion of foreign aid. In addition to its mode of delivery, missionary work is also of interest as there is a known positive correlation between the growth rate of Christianity and economic development. We estimate the economic growth impacts of development aid versus missionary work variables by using empirical data from 119 countries and discuss several explanations for our empirical results.
MOESM1 of Shifts in FGM/C practice in Sudan: communitiesâ€™ perspectives and drivers
Creators: name: Bedri, Nafisa
name: Sherfi, Huda
name: Rudwan, Ghada
name: Elhadi, Sara
name: Kabiru, Caroline
name: Amin, Wafaa
Publisher: name: figshare
Year: 2019
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Socio-demographic Characteristics of the Study Participants.
Chiquitano Santos-Silva & Galileo & Wappes 2017, gen. nov.
Creators: name: Santos-Silva, Antonio
name: Galileo, Maria Helena M.
name: Wappes, James E.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Chiquitano

description: Chiquitano gen. nov.
 Type species: Chiquitanovolcanesensis sp. nov.
 Etymology. Chiquitano: a native ethnic people living in Santa Cruz Department, Bolivia, where the specimens of the type species were collected. Masculine gender.
 Diagnosis. Male meso- and metatibiae cylindrical, tumid and not laterally carinate.
 Description. Head not notably constricted behind eyes. Eyes not divided; upper eye lobes with 3–4 rows of ommatidia. Antennal tubercles separated. Antennae 11-segmented and surpassing elytral apex in both sexes; scape subcylindrical, slightly widened toward apex; antennomeres III–XI filiform, not carinate; basal antennomeres in male not distinctly tumid; antennomere III about 1.3 times longer than IV and 1.1 times longer than V. Prothorax cylindrical, about 1.4 times longer than wide in both sexes. Pronotum not microsculptured, with 5 moderately distinct gibbosities, not striate, nearly entirely pubescent. Procoxal cavities slightly open behind. Prosternum entirely pubescent in basal half, not forming V-shaped area. Elytra elongate, parallel-sided, apex subtruncate, without spines, pubescent, with long, erect, moderately abundant setae. Profemora fusiform; meso- and metafemora moderately pedunculate-clavate; apex of femora without spine or projection; apex of metafemora distinctly not reaching elytral apex. Tibiae lacking lateral carina in both sexes; male meso- and metatibiae cylindrical, tumid; female meso- and metatibiae not tumid, somewhat flattened laterally. Metatarsomere Iabout as long as II and III together in both sexes.
 Remarks. Although the new genus has some features aberrant to Neoibidionina (Martins and Galileo 2007), such as female basal antennomeres not carinate, prosternum with pubescence not V-shaped and metatibiae not carinate laterally, it is included here especially because of its cylindrical scape and open procoxal cavities.
description: Published as part of Santos-Silva, Antonio, Galileo, Maria Helena M. & Wappes, James E., 2017, Descriptions, notes and reassignments in Neoibidionini (Coleoptera: Cerambycidae: Cerambycinae) with a new genus, three new species and keys to species of Brechmoidion Martins, 1969, Compsibidion Thomson, 1864 and Rhysium Pascoe, 1866, pp. 1-21 in Insecta Mundi 2017 (560) on page 2, DOI: 10.5281/zenodo.5183126
A Resale Explanation for the Declining Price Anomaly in Sequential Auctions
Creators: name: Tu, Zhiyong
name: Tu, Zhiyong
Publisher: name: Unknown
Year: 2010
Subjects: subject: Demand and Price Analysis
subject: Marketing
subject: FOS: Economics and business
subject: Public Economics
subject: Research Methods/ Statistical Methods
subject: Sequential common-value auction
subject: resale
subject: declining prices

description: This paper studies price trends in a sequential first-price common-value auction with resale. It differs from the previous research in that it considers sequential auctions with multi-unit demand. In the two-stage case, we propose a condition that guarantees the existence of a symmetric monotonic equilibrium which exhibits a declining trend. This is because bidders have the incentive to overbid in the first round to lower their rivals' intertemporal inference on the object value so that they can obtain a second-stage advantage. We also characterize the necessary properties of symmetric monotonic equilibria in the finite N-stage and the infinite-stage cases. In the former case, the price trend remains constant and drops only at the last stage; in the latter case, we have a constant price trend throughout.
A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability
Creators: name: Boyang Sun
name: Jing, Huang
name: Mabrouk, Moustafa T.
name: Yumiao Zhang
name: Honglin Jin
name: Lovell, Jonathan F.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Pluronic (Poloxomer) micelles can solubilize cabazitaxel (CTX), a second generation taxane, and then be subjected to low-temperature “surfactant-stripping” to selectively remove loose and free surfactant, thereby increasing the drug-to-surfactant ratio. We previously found that addition of certain other co-loaded hydrophobic cargo to the micelles can result in stabilized, surfactant-stripped cabazitaxel (sss-CTX) micelles, which resist drug aggregation in aqueous storage, a common challenge for taxanes. Here, we show that elevated temperatures can accelerate the aggregation of sss-CTX micelles, thereby enabling rapid optimization of formulations with respect to the type and ratio of co-loader used for stabilization. A sss-CTX micelle formulation was developed using mifepristone as the co-loader, at a 60% mass ratio to the CTX. Drug release, hemolysis and complement activation were investigated in vitro. Microtubule stabilization and in vitro cytotoxicity were similar for sss-CTX and a conventional Tween-80 micelle formulation. In vivo pharmacokinetics also revealed similar blood circulation of the two formulations. In subcutaneous Lewis lung carcinoma tumors, as well as in an aggressive mouse model of malignant pleural effusion, sss-CTX showed a similar therapeutic effect as the Tween-80 based formulation. Altogether, these data show that sss-CTX can achieve similar efficacy as conventional Tween-80 formulations, albeit with substantially higher drug-to-surfactant ratio and with capability of extended aqueous storage.
Data Management at the ICSU/WMO World Data Center for Remote Sensing of the Atmosphere (WDC-RSAT)
Creators: name: Sommer, Peter
name: Hildenbrand, Beate
name: Bernonville, Severine
name: Goussev, Oleg
name: Höppner, Kathrin
name: Bittner, Michael
Publisher: name: Geographisches Institut der Universität zu Köln - Kölner Geographische Arbeiten
Year: 2010
Subjects: Data Management
Metadata
Remote Sensing
Atmosphere

description: WDC-RSAT is hosted and operated by the German Remote Sensing Data Center, DFD of the German Aerospace Center (DLR) under the nongovernmental auspices of the International Council for Science (ICSU) and is the most recent data center in the WMO-WDC family, in cooperation with the World Meteorological Organization (WMO). WDC-RSAT cooperates with partners in establishing and making use of modern information technologies (e.g. Grid) in order to promote networking. It is already being implemented as a data publication agent for data related to remote sensing of the atmosphere and is thus authorized to assign so-called Digital Object Identifiers (DOI) to data sets. The German ICSU WDCs (WDC-Climate, WDC-Mare, WDC-Terra, and WDC-RSAT) have formed in 2004 the 'WDC-Cluster on Earth System Research' in order to promote interdisciplinary research related to Earth sciences. Following the recommendations of the Committee of Earth Observation Satellites (CEOS), WDC-RSAT is currently establishing in cooperation with NASA a portal for satellite-based atmospheric composition data (ACC) which ultimately will be integrated in the Global Earth Observation System of Systems (GEOSS).
description: Proceedings of the Data Management Workshop, 29-30 October 2009, University of Cologne, Germany, Kölner Geographische Arbeiten, 90, pp. 119-125
Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals
Creators: name: Alptug Karakucuk
name: Tort, Serdar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Hematology

description: The objective of this study was to develop resveratrol nanocrystals to solve low water solubility issues of resveratrol and adsorb them to the polycaprolactone nanofibers. Nanocrystals were prepared by microfluidization. Particle size, polydispersity index and zeta potential values were evaluated as dependent variables. Polycaprolactone (PCL) nanofibers were prepared via electrospinning method and the flow rate, electrical voltage and tip-to-needle distance were set to 3 mL/h, 13 kV and 15 cm, respectively. Optimum resveratrol nanocrystals were lyophilized and re-suspended in water and physically adsorbed to PCL nanofibers with two different concentrations (0.2 and 1 mg/cm2). Bioadhesion, wettability, solubility, drug loading and antimicrobial activity against P. acnes studies were carried out. Final nanocrystals showed 800 nm of particle size, 0.4 of polydispersity index, and -8 mV of zeta potential. Nanocrystals successfully adsorbed to PCL nanofibers proven on SEM images with adsorption efficiencies >70%. Addition of resveratrol crystals decreased the contact angle of PCL from 128° to 50°. The solubility of resveratrol nanocrystals enhanced ∼5-fold in comparison with coarse powder. Effective antimicrobial activity against P.acnes was observed. It is concluded that nanocrystal loading on nanofibers brings advantage into preparing easy to use dermal patches for acne treatment or skin disorders.
Additional file of Haem relieves hyperoxia-mediated inhibition of HMEC-1 cell proliferation, migration and angiogenesis by inhibiting BACH1 expression
Creators: name: Jian, Lan
name: Mei, Yang
name: Xing, Chen
name: Rongdi, Yuan
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Additional file of Haem relieves hyperoxia-mediated inhibition of HMEC-1 cell proliferation, migration and angiogenesis by inhibiting BACH1 expression
The late time radio emission from SN 1993J at meter wavelengths
Creators: name: Chandra, P.
name: Ray, A.
name: Bhatnagar, S.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the investigations of SN 1993J using low frequency observations with the Giant Meterwave Radio Telescope. We analyze the light curves of SN 1993J at 1420, 610, 325 and 243 MHz during $7.5-10$ years since explosion.The supernova has become optically thin early on in the 1420 MHz and 610 MHz bands while it has only recently entered the optically thin phase in the 325 MHz band. The radio light curve in the 235 MHz band is more or less flat. This indicates that the supernova is undergoing a transition from an optically thick to optically thin limit in this frequency band. In addition, we analyze the SN radio spectra at five epochs on day 3000, 3200, 3266, 3460 and 3730 since explosion. Day 3200 spectrum shows a synchrotron cooling break. SN 1993J is the only young supernova for which the magnetic field and the size of the radio emitting region are determined through unrelated methods. Thus the mechanism that controls the evolution of the radio spectra can be identified. We suggest that at all epochs, the synchrotron self absorption mechanism is primarily responsible for the turn-over in the spectra. Light curve models based on free free absorption in homogeneous or inhomogeneous media at high frequencies overpredict the flux densities at low frequencies. The discrepancy is increasingly larger at lower and lower frequencies. We suggest that an extra opacity, sensitively dependent on frequency, is likely to account for the difference at lower frequencies. The evolution of the magnetic field (determined from synchrotron self absorption turn-over) is roughly consistent with $B \propto t^{-1}$. Radio spectral index in the optically thin part evolves from $α\sim 0.8-1.0$ at few tens of days to $\sim 0.6$ in about 10 years.
description: 37 pages, 9 figures in LaTex; scheduled for ApJ 10 September 2004, v612 issue; send comments to: poonam@tifr.res.in
Factors Affecting Rural Facilitators’ Role: Iran
Creators: name: Azimi, Farideh
name: Kamali, Mohammad Bagher
name: Azimi, Farideh
name: Kamali, Mohammad Bagher
Publisher: name: Unknown
Year: 2011
Subjects: subject: Farm Management
subject: Rural female facilitators
subject: Facilitation
subject: Rural development
subject: Appreciative inquiry
subject: Iran

description: This study aimed to examine key factors affecting rural female facilitators’ role in participatory rural development in Tehran Province. Since the researchers intended to have a better insight into the facilitators’ role and employ inquiry as a learning forum for bringing about changes for all participants, they preferred to use a case study based upon an appreciative inquiry method. The study divided the factors affecting the facilitators’ role into two main categories: driving factors and preventing factors. The former are: two-way communication, election of rural eligible facilitators, participation, sense of responsibility, and the latter are: cultural and tribal fanaticism, lack of permanent female extension workers and frequent management changes. Appreciative inquiry as a positive mode of action research could facilitate the process of education and communication for all stakeholders. We suggested that there should be a shift from the extension as a knowledge transfer to facilitation as people’s own knowledge creation. This study showed that appreciative inquiry could facilitate the process of change and gender-awareness. This research method could also facilitate mutual communication between the rural facilitators and extension workers.
Prediction of Saxagliptin Stability using a New Approach Based on Partial Least Squares and Design of Experiments
Creators: name: Jordan, Nika
name: Zakrajšek, Jure
name: Bohanec, Simona
name: Roškar, Robert
name: Grabnar, Iztok
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: The objective of this study was to assess the possibility of applying Partial Least Squares (PLS) statistics with the use of experimental design approach towards stability evaluation of the Saxagliptin drug product. The influences of temperature, time, dose, packaging, batch, and oxygen protection were analyzed for identification of critical factors responsible for degradation of saxagliptin and prediction of impurity levels at various storage conditions. Predicted levels of the impurity DP-2 were lower for at least 0.2 % when the drug product was protected from oxygen after its manufacture. Additionally, the PLS model revealed that the lower strength is at least twice less stable concerning impurity DP-1. Based on this analysis shelf life for Zone II was proposed at 24 months with high reliability. Comparison of the PLS model estimates with the measured stability data at shelf life revealed good predictive ability of the developed model. Moreover, PLS predictions of DP-1 and Total impurities were more accurate than those obtained with a standard linear least squares regression, while DP-2 predictions were at least as accurate. We can thus propose a more extensive use of this approach for stability evaluation of pharmaceuticals.
Assessment the Socio-economic Factors Affecting Rural Youth Attitude to Occupation in Agricultural (Case of Kohgiluyeh and Boyer- Ahmad Province, Iran)
Creators: name: Mosaee, Mohsen
name: Ommani, Ahmadreza
name: Mosaee, Mohsen
name: Ommani, Ahmadreza
Publisher: name: Unknown
Year: 2011
Subjects: subject: Farm Management
subject: Youth
subject: Attitude
subject: Agriculture
subject: Kogilouyh and Boyerahmad province

description: The main objective in this causal-correlation field research was to identify effective factors on rural youth's attitude towards agricultural occupation, in Kohgiluyeh and Boyer-Ahmad Province, Iran. Rural youth 15-25 years old in Kohgiluyeh and Boyer- Ahmad province were the population of this study. The technique of sampling was cluster sampling. The technique of data collection is questionnaire. The panel of experts was used to validity of the questionnaire. Corenbach Alpha was used to gain assurance of the reliability of the questionnaire (α=0.79). The results of multivariate regression indicate the variables of type of farming system, rate of relation to organizations, participation in extension and education courses, insurance, age and income have the main role in showing the variations of attitude to agricultural occupation.
MOESM1 of The higher education space: connecting degree programs from individuals’ choices
Creators: name: Candia, Cristian
name: Encarnação, Sara
name: Pinheiro, Flávio
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Supplementary describes in detail the data pre-processing and the analysis of degree program characteristics (PDF 1.2 MB)
Universality of the thermodynamic Casimir effect
Creators: name: Dantchev, Daniel
name: Krech, Michael
name: Dietrich, S.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Recently a nonuniversal character of the leading spatial behavior of the thermodynamic Casimir force has been reported [X. S. Chen and V. Dohm, Phys. Rev. E {\bf 66}, 016102 (2002)]. We reconsider the arguments leading to this observation and show that there is no such leading nonuniversal term in systems with short-ranged interactions if one treats properly the effects generated by a sharp momentum cutoff in the Fourier transform of the interaction potential. We also conclude that lattice and continuum models then produce results in mutual agreement independent of the cutoff scheme, contrary to the aforementioned report. All results are consistent with the {\em universal} character of the Casimir force in systems with short-ranged interactions. The effects due to dispersion forces are discussed for systems with periodic or realistic boundary conditions. In contrast to systems with short-ranged interactions, for $L/ξ\gg 1$ one observes leading finite-size contributions governed by power laws in $L$ due to the subleading long-ranged character of the interaction, where $L$ is the finite system size and $ξ$ is the correlation length.
description: 11 pages, revtex, to appear in Phys. Rev. E 68 (2003)
PAEDIATRIC EMERGENCIES
Creators: name: Jumayev, Firdavs
name: Eshmamatov, Norbek
name: Akhmedov, Y.M.
Publisher: name: Zenodo
Year: 2025

description: The article provides valuable information regarding emergencies involving children, highlighting a systematic approach for responding to these critical circumstances. It serves as an informative resource designed to help readers understand the fundamentals of first aid and the essential role of anesthesiology and resuscitation services in pediatric emergencies. In emergency scenarios, children often present unique challenges due to their physiological differences and developmental stages. The article outlines various common emergency conditions, such as respiratory distress, choking, allergic reactions, and trauma, along with clear algorithms to guide responders in these high-pressure situations. These algorithms serve as step-by-step instructions for caregivers, healthcare professionals, and bystanders, enabling them to act swiftly and effectively when a child is in crisis.
Profiling gene expression dynamics underpinning conventional testing approaches to better inform pre-clinical evaluation of an age appropriate spironolactone formulation
Creators: name: Russell, Craig
name: Majad Hussain
name: Huen, David
name: Rahman, Ayesha S.
name: Mohammed, Afzal R.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: There is a need to accelerate paediatric formulation evaluation and enhance quality of early stage data in drug development to alleviate the information pinch point present between formulation development and clinical evaluation. This present work reports application of DNA microarrays as a high throughput screening tool identifying markers for prediction of bioavailability and formulation driven physiological responses. With a focus on enhancing paediatric medicine provision, an oral liquid spironolactone suspension was formulated addressing a paediatric target product profile. Caco-2 cells cultured on transwell inserts were implemented in transport assays in vitro and DNA microarrays were used to examine gene expression modulation. Wistar rats were used to derive in vivo bioavailability data. In vitro, genomic, and in vivo data sets were concurrently evaluated linking drug transport and the genomic fingerprint generated by spironolactone formulation exposure. Significant changes in gene expression are reported as a result of formulation exposure. These include genes coding for ATP-binding cassette (ABC) transporters, solute carrier (SLC) transporters, cytochrome P450 (CYP) enzymes, and carboxylesterase enzymes. Genomic findings better inform pre-clinical understanding of pharmacokinetic and pharmacodynamic responses to spironolactone and its active metabolites than current in vitro drug transport assays alone.
MOESM1 of Comparative photon and proton dosimetry for patients with mediastinal lymphoma in the era of Monte Carlo treatment planning and variable relative biological effectiveness
Creators: name: Tseng, Yolanda
name: Shadonna Maes
name: Kicska, Gregory
name: Sponsellor, Patricia
name: Traneus, Erik
name: Wong, Tony
name: Stewart, Robert
name: Saini, Jatinder
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Figure S1. RBE for DSB induction (RBEDSB) and the low dose [compared to (α/β)R] RBE for cell survival (RBELD). Left Panel: RBE as a function of proton kinetic energy. A (and grey shaded region) denotes the approximate range of proton energies (“energy layers”) incident on patient (~ 90 to 225 MeV). Right Panel: RBE as a function of the continuous slowing down approximation (CSDA) range for a monoenergetic proton in water. Filled green squares denote estimates of RBE DSB from track structure simulations [64]. Filled red squares [(α/β)R = 10 Gy] and yellow triangles [(α/β)R = 2 Gy] denote LEM IV estimates of the RBE for cell survival after a 1.8 Gy absorbed dose (LEM IV data adapted from [36]). Solid black lines in the left and right panel are estimates of RBEDSB from the MCDS [31, 33]. Dashed lines are computed using Eq. (1) with (α/β)R = 1 Gy, 5 Gy and 10 Gy and an effective cell diameter of 4 μm. At the proton end of range (left panel, blue shaded region), the RBE for the last-traversed-cell may be as large as 2 to 3.7. However, the RBE for most cells near the tip of a pristine Bragg peak (red shaded regions) is likely to be much closer to 1.1 (~ 1.05 to 1.25). Distal to a pristine Bragg peak, RBEDSB and the RBE for cell survival rapidly rises to values that may approach 2.0 to 3.7 (blue shaded region in left panel). Figure S2. Proton RBE as a function of linear energy transfer (LET). Solid black line: MCDS estimate of RBEDSB [31, 33]. Dashed lines: RMF model [35, 36] with (α/β)R = 1 Gy, 5 Gy and 10 Gy (cell diameter = 4 μm). Red filled circles: LEM IV model estimate of the RBE for cell survival with (α/β)R = 2 Gy and 10 Gy [36]. Yellow triangles: Microdosimetric-Kinetic (MK) model estimate of the RBE for cell survival with (α/β)R = 2 Gy and 10 Gy [36]. Filled cyan squares: Wedenberg et al. [63] model of the RBE (1.8 Gy) for cell survival with (α/β)R = 2 Gy and 10 Gy. Filled stars: McNamara et al. [63] model of the RBE (1.8 Gy) for cell survival with (α/β)R = 2 Gy and 10 Gy. Blue shaded region corresponds to an RBE slope in the range from + 0.03 to + 0.09 per keV/μm.
Point-like sources of Euclidean non-abelian field in the instanton liquid
Creators: name: Molodtsov, S. V.
name: Zinovjev, G. M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: An appraisal of average energy of Euclidean non-abelian point-like source in the instanton liquid is calculated. It behaves linearly increasing at large distances while unscreened. For the dipole in colour singlet state this energy increases linearly again with the separation increasing and its "tension" coefficient develops the magnitude pretty similar to the lattice approach and other model estimates. The situation of sources arbitrary oriented in colour space is perturbatively considered.
description: 8 pages
X-Ray Emission from the Double Pulsar System J0737-3039
Creators: name: McLaughlin, M. A.
name: Camilo, F.
name: Burgay, M.
name: D'Amico, N.
name: Joshi, B. C.
name: Kramer, M.
name: Lorimer, D. R.
name: Lyne, A. G.
name: Manchester, R. N.
name: Possenti, A.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on a 10 ksec observation of the double pulsar system J0737-3039 obtained with the Chandra X-ray Observatory's Advanced CCD Imaging Spectrometer. We detect the system as a point source with coordinates (J2000) RA = 07:37:51.23, Decl. = -30:39:40.9, making this the first double neutron star system to be detected at X-ray energies. Only 77 source counts are detected. The data are represented satisfactorily by a power-law spectrum with photon index = 2.9 +/- 0.4. The inferred 0.2-10 keV luminosity is approximately 2e30 erg/s for a distance of 0.5 kpc. We do not detect any significant variability with orbital phase in these data, which span one full orbit. These results are consistent with the X-ray emission originating solely from the magnetosphere of the energetic A pulsar, with an efficiency for conversion of rotational energy to X-rays in this band of roughly 0.04%, although we cannot exclude other possibilities.
description: 5 pages, 4 figures, accepted by ApJ Letters
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title: High-order heuristic fuzzy forecasting model with hedge algebra
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name: Ð§ÐµÑÐ½ÐµÐ½ÑÐºÐ°Ñ , ÐÑÐ´Ð¼Ð¸Ð»Ð°
name: "Ð¡Ð¸ÑÑÐµÐ¼Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð² Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¸", Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð°Ñ Ð½Ð°ÑÑÐ½Ð¾-Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ñ (27; 2023; Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³)
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2024
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forecasting models
higher order fuzzy models
heuristic models
hedge algebra
fuzzy relation groups
linguistic variables
fuzzification
defuzzification

description: Ð ÑÑÐ°ÑÑÐµ Ð¿ÑÐµÐ´Ð»Ð°Ð³Ð°ÐµÑÑÑ Ð½Ð¾Ð²Ð°Ñ ÑÐ²ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ Ð´Ð»Ñ Ð½ÐµÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ´Ð¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð½ÐµÑÐµÑÐºÐ¸Ñ Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¹ Ð²ÑÑÐ¾ÐºÐ¾Ð³Ð¾ Ð¿Ð¾ÑÑÐ´ÐºÐ° Ð² ÑÐ¾ÑÐµÑÐ°Ð½Ð¸Ð¸ Ñ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð¼ ÑÐµÐ´Ð¶-Ð°Ð»Ð³ÐµÐ±ÑÑ. ÐÐ¾Ð´ÐµÐ»Ñ Ð±ÑÐ»Ð° Ð¿ÑÐ¾ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð° Ð½Ð° Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð´Ð°Ð½Ð½ÑÑ. ÐÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÑÐµÐ¼ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¾ÑÐµÐ½ÐµÐ½Ñ Ð¸ ÑÑÐ°Ð²Ð½ÐµÐ½Ñ Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ð¼Ð¸ Ð¼Ð¾Ð´ÐµÐ»ÑÐ¼Ð¸. ÐÐ½Ð°Ð»Ð¸Ð· Ð¿Ð¾ÐºÐ°Ð·Ð°Ð», ÑÑÐ¾ Ð¿ÑÐµÐ´Ð»Ð°Ð³Ð°ÐµÐ¼Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ Ð¸Ð¼ÐµÐµÑ Ð±Ð¾Ð»ÐµÐµ Ð²ÑÑÐ¾ÐºÑÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ.
description: This paper proposes a new heuristic model for fuzzy time series forecasting using high-order fuzzy relations combined with a hedge algebra approach. The model was tested on practical data. The forecasted results are evaluated and compared with existing models and it is shown that the proposed model has higher performance.
Nanoparticles integrating natural and synthetic polymers for in vivo insulin delivery
Creators: name: Safy Hadiya
name: Radwa Radwan
name: Zakaria, Menna
name: Tahra El-Sherif
name: Hamad, Mostafa A.
name: Elsabahy, Mahmoud
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The aims of the current study were to develop insulin-loaded nanoparticles comprised of various polymers at different compositions, and to evaluate their ability to lower blood glucose levels in diabetic rats following subcutaneous and oral administrations. Several combinations of natural and synthetic polymers have been utilized for preparation of nanoparticles including, chitosan, alginate, albumin and Pluronic. Nanosized (170 nm–800 nm) spherical particles of high encapsulation efficiency (15–52%) have been prepared. Composition and ratios between the integrated polymers played a pivotal role in determining size, zeta potential, and in vivo hypoglycemic activity of particles. After subcutaneous and oral administration in diabetic rats, some of the insulin-loaded nanoparticles were able to induce much higher hypoglycemic effect as compared to the unloaded free insulin. For instance, subcutaneous injection of nanoparticles comprised of chitosan combined with sodium tripolyphosphate, Pluronic or alginate/calcium chloride, resulted in comparable hypoglycemic effects to free insulin, at two-fold lower dose. Nanoparticles were well-tolerated after oral administration in rats, as evidenced by by measuring levels of alanine aminotransferase, aspartate aminotransferases, albumin, creatinine and urea. This study indicates that characteristics and delivery efficiency of nanomaterials can be controlled via utilizing several natural/synthetic polymers and by fine-tuning of combination ratio between polymers.
Additional file 1 of Risk of Mycoplasma pneumoniae-related hepatitis in MP pneumonia pediatric patients: a predictive model construction and assessment
Creators: name: Bi, Yuna
name: Ma, Yan
name: Zhuo, Jinhua
name: Zhang, Lili
name: Yin, Liyan
name: Sheng, Hongling
name: Luan, Jie
name: Li, Tao
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1: Table S1. Characterististics of the pneumonia pediatric patients without MP infection (n = 175 ), the external pediatric patients with MP pneumonia validation set (n = 84 ) and health control (n = 93 ).
A New Approach to Turbulent Transport of a Mean Scalar
Creators: name: Blackman, Eric G.
name: Field, George B.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We develop a simple mean field approach to the transport of a passive scalar for which the fundamental equation is a second order differential equation in the transported quantity, not a first order equation. Triple correlations are included, as they must be for any realistic description of turbulence. No correlation time enters the theory, only an eddy turnover time. The approach is simpler than standard approaches which incorporate triple correlations, but more realistic than Gaussian or short correlation time closures which do not. A similar approach has proven useful in magnetohydrodynamics.
description: 8 Pages, LaTeX, version in press, Physics of Fluids (Letters)
Runaway O-star Bow Shocks as Particle Accelerators? The Case of AE Aur revisited
Creators: name: Rangelov, Blagoy
name: Montmerle, Thierry
name: Federman, S. R.
name: Boisse, Patrick
name: Gabici, Stefano
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present results of our Chandra/ACIS observations of the field centered on the fast, runaway O star AE Aur and its bow shock. Previous XMM-Newton observations revealed an X-ray "blob" near the IR arc tracing the bow shock, possibly a nonthermal source consistent with models of Inverse Compton scattering of dust IR photons by electrons accelerated at the shock. The new, subarcsecond resolution Chandra data, while confirming the presence of the XMM-Newton source, clearly indicate that the latter is neither extended nor coincident with the IR arc and strongly suggest it is a background AGN. Motivated by results published for the bow shock of BD+43 3654, we extended our study to the radio domain, by analyzing archival EVLA data. We find no radio emission from the AE Aur bow shock either. The corresponding upper limits for the absorbed (unabsorbed) X-ray flux of 5.9(7.8)x10^-15 erg/cm^2/s (3 sigma) and, in the radio range, of 2 mJy (1.4 GHz), and 0.4 mJy (5.0 GHz), are used to put constraints on model predictions for particle acceleration within the bow shock. In the "classical" framework of Diffusive Shock Acceleration, we find that the predicted X-ray and radio emission by the bow shock is at least two orders of magnitude below the current upper limits, consistent with the systematic non-detections of up to 60 stellar bow shocks. The only exception so far remains that of BD+43 3654, probably the result of its very large mass-loss rate among runaway O stars.
description: Accepted for publication in ApJ
Automorphism covariant representations of the holonomy-flux *-algebra
Creators: name: Okolow, Andrzej
name: Lewandowski, Jerzy
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We continue an analysis of representations of cylindrical functions and fluxes which are commonly used as elementary variables of Loop Quantum Gravity. We consider an arbitrary principal bundle of a compact connected structure group and following Sahlmann's ideas define a holonomy-flux *-algebra whose elements correspond to the elementary variables. There exists a natural action of automorphisms of the bundle on the algebra; the action generalizes the action of analytic diffeomorphisms and gauge transformations on the algebra considered in earlier works. We define the automorphism covariance of a *-representation of the algebra on a Hilbert space and prove that the only Hilbert space admitting such a representation is a direct sum of spaces L^2 given by a unique measure on the space of generalized connections. This result is a generalization of our previous work (Class. Quantum. Grav. 20 (2003) 3543-3567, gr-qc/0302059) where we assumed that the principal bundle is trivial, and its base manifold is R^d.
description: 34 pages, 1 figure, LaTeX2e, minor clarifying remarks
Additional file 2 of Risk of Mycoplasma pneumoniae-related hepatitis in MP pneumonia pediatric patients: a predictive model construction and assessment
Creators: name: Bi, Yuna
name: Ma, Yan
name: Zhuo, Jinhua
name: Zhang, Lili
name: Yin, Liyan
name: Sheng, Hongling
name: Luan, Jie
name: Li, Tao
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 2: Table S2. ROC analysis of MRP for MP-related hepatitis diagnosis in different patients’ age and MP-IgM titer subgroups.
Physicochemical, pharmacokinetic, and pharmacodynamic characterization of isradipine tablets for controlled release
Creators: name: D. Nagasamy Venkatesh
name: S. N. Meyyanathan
name: R. Shanmugam
name: S. S. Kamatham
name: J. R. Campos
name: J. Dias-Ferreira
name: E. Sanchez-Lopez
name: J. C. Cardoso
name: P. Severino
name: E. B. Souto
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Isradipine is a dihydropyridine calcium channel blocker (CCB) commonly used as vasodilator with antihypertensive properties. A remote-controlled release formulation for isradipine would substantially improve the clinical outcomes of the patients requiring chronic long-term treatment. In this work, sustained release (SR) tablets of isradipine, composed of hydroxypropylmethyl cellulose (HPMC), have been produced by wet granulation and their in vitro and in vivo characterization was compared to a conventional tablet dosage form of immediate release (IR) as preliminary assessment. Tablets composed of 15.0% (wt/wt) HPMC exhibited a SR profile over a period of 24 hours. The release of isradipine followed a Fickian diffusion pattern obeying to the first order kinetics and the extent of absorption was even higher in comparison to the developed conventional tablets, which showed immediate drug release. In vivo studies were carried out in rabbits, showing that the extent of isradipine absorption from the developed tablets was higher in comparison to IR tablets due to the modified release profile obtained for the former (p
MOESM2 of Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis
Creators: name: Droz, Nina
name: Yingfen Hsia
name: Ellis, Sally
name: Dramowski, Angela
name: Sharland, Mike
name: Basmaci, Romain
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Figure S1. Proportion of Gram positive bacteria (GPB) in paediatric sepsis.
Nanoparticles Integrating Natural and Synthetic Polymers for in vivo Insulin Delivery
Creators: name: Safy Hadiya
name: Radwa Radwan
name: Zakaria, Menna
name: Tahra El-Sherif
name: Hamad, Mostafa A.
name: Elsabahy, Mahmoud
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The aims of the current study were to develop insulin-loaded nanoparticles comprised of various polymers at different compositions, and to evaluate their ability to lower blood glucose levels in diabetic rats following subcutaneous and oral administrations. Several combinations of natural and synthetic polymers have been utilized for preparation of nanoparticles including, chitosan, alginate, albumin and Pluronic. Nanosized (170 nm-800 nm) spherical particles of high encapsulation efficiency (15-52%) have been prepared. Composition and ratios between the integrated polymers played a pivotal role in determining size, zeta potential, and in vivo hypoglycemic activity of particles. After subcutaneous and oral administration in diabetic rats, some of the insulin-loaded nanoparticles were able to induce much higher hypoglycemic effect as compared to the unloaded free insulin. For instance, subcutaneous injection of nanoparticles comprised of chitosan combined with sodium tripolyphosphate, Pluronic or alginate/calcium chloride, resulted in comparable hypoglycemic effects to free insulin, at two-fold lower dose. Nanoparticles were well-tolerated after oral administration in rats, as evidenced by by measuring levels of alanine aminotransferase, aspartate aminotransferases, albumin, creatinine and urea. This study indicates that characteristics and delivery efficiency of nanomaterials can be controlled via utilizing several natural/synthetic polymers and by fine-tuning of combination ratio between polymers.
Quasiparticle relaxation dynamics in heavy fermion compounds
Creators: name: Demsar, J.
name: Averitt, R. D.
name: Ahn, K. H.
name: Graf, M. J.
name: Trugman, S. A.
name: Kabanov, V. V.
name: Sarrao, J. L.
name: Taylor, A. J.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present the first femtosecond studies of electron-phonon (e-ph) thermalization in heavy fermion compounds. The e-ph thermalization time tau_{ep} increases below the Kondo temperature by more than two orders of magnitude as T = 0 K is approached. Analysis using the two-temperature model and numerical simulations based on Boltzmann's equations suggest that this anomalous slowing down of the e-ph thermalization derives from the large electronic specific heat and the suppresion of scattering between heavy electrons and phonons.
description: 4 pages, 3 figures, accepted for publication in Phys. Rev. Lett
Profiling gene expression dynamics underpinning conventional testing approaches to better inform pre-clinical evaluation of an age appropriate spironolactone formulation
Creators: name: Russell, Craig
name: Majad Hussain
name: Huen, David
name: Rahman, Ayesha S
name: Mohammed, Afzal R
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: There is a need to accelerate paediatric formulation evaluation and enhance quality of early stage data in drug development to alleviate the information pinch point present between formulation development and clinical evaluation. This present work reports application of DNA microarrays as a high throughput screening tool identifying markers for prediction of bioavailability and formulation driven physiological responses. With a focus on enhancing paediatric medicine provision an oral liquid spironolactone suspension was formulated addressing a paediatric target product profile. Caco-2 cells cultured on transwell inserts were implemented in transport assays in vitro and DNA microarrays were used to examine gene expression modulation. Wistar rats were used to derive in vivo bioavailability data. In vitro, genomic and in vivo data sets were concurrently evaluated linking drug transport and the genomic fingerprint generated by spironolactone formulation exposure. Significant changes in gene expression are reported as a result of formulation exposure. These include genes coding for ATP-binding cassette (ABC) transporters, Solute carrier (SLC) transporters, Cytochrome P450 (CYP) enzymes and carboxylesterase enzymes. Genomic findings better inform pre-clinical understanding of pharmacokinetic and pharmacodynamic responses to spironolactone and its active metabolites than current in vitro drug transport assays alone.