cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Asymptotic Analysis of Structured Determinants via the Riemann-Hilbert Approach
Creators: name: Gharakhloo, Roozbeh
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mathematical physics not elsewhere classified
Integrable systems (classical and quantum)
Approximation theory and asymptotic methods

description: In this work we use and develop Riemann-Hilbert techniques to study the asymptotic behavior of structured determinants. In chapter one we will review the main underlyingdefinitions and ideas which will be extensively used throughout the thesis. Chapter two is devoted to the asymptotic analysis of Hankel determinants with Laguerre-type and Jacobi-type potentials with Fisher-Hartwig singularities. In chapter three we will propose a Riemann-Hilbert problem for Toeplitz+Hankel determinants. We will then analyze this Riemann-Hilbert problem for a certain family of Toeplitz and Hankel symbols. In Chapter four we will study the asymptotics of a certain bordered-Toeplitz determinant which is related to the next-to-diagonal correlations of the anisotropic Ising model. The analysis is based upon relating the bordered-Toeplitz determinant to the solution of the Riemann-Hilbert problem associated to pure Toeplitz determinants. Finally in chapter ve we will study the emptiness formation probability in the XXZ-spin 1/2 Heisenberg chain, or equivalently, the asymptotic analysis of the associated Fredholm determinant.
sj-pdf-1-imr-10.1177_03000605211029504 - Supplemental material for A variant in the 3ʹ-untranslated region of the MC2R gene decreases the risk of schizophrenia in a female Han Chinese population
Creators: name: Tang, Liang
name: Xiang, Qin
name: Xiang, Ju
name: Li, Jianming
name: Chen, Danna
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605211029504 for A variant in the 3ʹ-untranslated region of the MC2R gene decreases the risk of schizophrenia in a female Han Chinese population by Liang Tang, Qin Xiang, Ju Xiang, Jianming Li and Danna Chen in Journal of International Medical Research
sj-pdf-1-eso-10.1177_23969873211030842 - Supplemental material for European stroke organization interim expert opinion on cerebral venous thrombosis occurring after SARS-CoV-2 vaccination
Creators: name: Ferro, José M
name: Sousa, Diana Aguiar de
name: Coutinho, Jonathan M
name: Martinelli, Ida
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-eso-10.1177_23969873211030842 for European stroke organization interim expert opinion on cerebral venous thrombosis occurring after SARS-CoV-2 vaccination by José M Ferro, Diana Aguiar de Sousa, Jonathan M Coutinho and Ida Martinelli in European Stroke Journal
sj-docx-1-mre-10.1177_14707853211030482 – Supplemental material for Does sustainable consumption make consumers happy?
Creators: name: Ramos-Hidalgo, Encarnación
name: Diaz-Carrion, Rosalia
name: Rodríguez-Rad, Carlos
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-mre-10.1177_14707853211030482 for Does sustainable consumption make consumers happy? by Encarnación Ramos-Hidalgo, Rosalia Diaz-Carrion and Carlos Rodríguez-Rad in International Journal of Market Research
Understanding the Science Practice-Linked Identities of Preservice Elementary Teachers
Creators: name: Nardo, Jocelyn Elizabeth
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Theoretical and computational chemistry not elsewhere classified

description: Science is an area of study with unique particularities concerning what “counts” as scientific practices where some learners are legitimized, while other learners are not. Such is the case for preservice elementary teachers (hereafter PSETs) –a population characterized by the literature as being in-need of science intervention. However, most of the literature deficiently conceptualizes PSETs’ science learning, so I sought for ways to refigure their learning positively. Drawing from Van Horne and Bell’s (2017) constructs of practice-linked and disciplinary identity, I offer that PSETs have nuanced, complex science identities that are influenced by their lived experiences inside and outside the classroom. To investigate the lived experiences of PSETs both inside and outside the classroom, 10 video-recorded, focus-group interviews were done while PSETs were undertaking an undergraduate chemistry-content course. Students were asked about their relationships with science as past elementary and high school students, as well as current undergraduate students. Students were also asked how they perceived their learning in the chemistry-content course. The research questions this work seeks to answer are:
• How do PSETs construct their science practice-linked identities?• How does Fundamentals of Chemistry afford identity resources that contribute to PSETs’ science practice-linked identities?
The data was coded for themes surrounding their science identities, teaching identities, and learning of each individual PSET. Using narrative analysis, I synthesized three allegories, “I am a science person,” and “I am not a science person,” and Ambiguous which aim to elucidate the spectrum of ways PSETs navigate science learning as a science person, a non-science person, and an unsure person. In addition to the PSETs’ stories, I also analyzed how the chemistry-content course curriculum afforded PSETs with identity-building resources that helped science learning as current students and as future elementary teachers. I found that PSETs’ science identities formed before the course impacted the ways they participated in the chemistry-content course (practice-linked identity), but the curriculum offered students opportunities to renegotiate their science identities and practice science in ways that felt more legitimate to themselves and their prospective careers. Overall, I hope this work informs how instructors can design courses that are sensitive towards the needs of their students and highlight the importance of having a curriculum that affords students with the chance to re-engage with disciplinary practices in which their identities are legitimized as meaningful for their learning.If science determines practices that “count,” science must also acknowledge whose practices are accounted.
Association between renal mean perfusion pressure and prognosis in patients with sepsis-associated acute kidney injury: insights from the MIMIC IV database
Creators: name: Fang, Yipeng
name: Dou, Aizhen
name: Xie, Hui
name: Zhang, Yunfei
name: Zhu, Weiwei
name: Zhang, Yingjin
name: Li, Caifeng
name: Su, Yanchao
name: Gao, Ying
name: Xie, Keliang
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Cell Biology
Biotechnology
Developmental Biology
Marine Biology
Science Policy

description: To investigate the association between renal mean perfusion pressure (MPP) and prognosis in sepsis-associated acute kidney injury (SA-AKI). Data were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Group-based trajectory modeling (GBTM) was applied to identify dynamic MPP patterns, while restricted cubic spline (RCS) curves were utilized to confirm the non-linear relationship between MPP and mortality. Cox regression analysis assessed the risk of mortality across different MPP levels, adjusting for potential confounders. Subgroup analyses and sensitivity analyses were conducted to ensure the robustness of the findings. A total of 2318 patients with SA-AKI were stratified into five MPP trajectories by GBTM. Patients in Traj-1 and Traj-2, characterized by consistently low MPP (<60 mmHg), demonstrated markedly higher 90-d mortality (62.86% and 26.98%). RCS curves revealed a non-linear inverse relationship between MPP and 90-d mortality, identifying 60 mmHg as the optimal threshold. Patients with MPP ≤ 60 mmHg exhibited significantly elevated 90-d mortality compared to those with MPP > 60 mmHg (29.81% vs. 20.88%). Cox regression analysis established Traj-1 and Traj-2 as independent risk factors for increased mortality relative to Traj-3 (60–70 mmHg), with hazard ratios (HRs) of 4.67 (95%-CI 3.28–6.67) and 1.45 (95%-CI 1.20–1.76). MPP > 60 mmHg was significantly associated with reduced 90-d mortality (HR 0.65, 95%-CI 0.55–0.77). Subgroup and PSM analyses supported these findings. Dynamic MPP trajectory serves as a valuable prognostic biomarker for SA-AKI. Early monitoring of MPP trends offers critical insights into renal perfusion management, potentially improving outcomes in SA-AKI.
Quality indicators and clinical outcomes: the role of care quality in nondiabetic chronic kidney disease management
Creators: name: Hsieh, Yun-Fang
name: Hsu, Le-Yin
name: Tsai, Ping-Hsiu
name: Tsai, Wan-Chuan
name: Ko, Mei-Ju
name: Chien, Kuo-Liong
name: Wu, Hon-Yen
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Science Policy

description: Quality indicators (QIs) are essential for evaluating healthcare quality, but their validation for nondiabetic chronic kidney disease (CKD) populations is limited. We aimed to assess the association between QIs and outcomes in nondiabetic CKD patients. Using Taiwan’s National Health Insurance claims data and death registries, we analyzed 27,842 nondiabetic adults with stage 3B-5 CKD from 2016 to 2019. Three QIs were assessed: renin–angiotensin system (RAS) inhibitor prescription, proteinuria testing, and nonsteroidal anti-inflammatory drug (NSAID) avoidance. Each patient received an overall QI score (range: 0–3) based on the sum of the individual QI scores. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between QI scores and outcomes, including long-term dialysis, all-cause death, hospitalization for acute kidney injury (AKI), hyperkalemia, and acidosis. The study population had a mean age of 68.7 years and a female prevalence of 41.7%. Only 33.5% of patients received the highest QI score. During a median follow-up period of 23 months, higher overall QI scores were associated with lower risks of long-term dialysis (HR 0.891, 95% CI 0.846–0.938), all-cause death (HR 0.900, 95% CI 0.864–0.939), and acidosis (HR 0.882, 95% CI 0.799–0.972). Notably, the prescription of RAS inhibitors was consistently correlated with better outcomes. These findings underscore the importance of quality indicators, particularly the continued use of RAS inhibitors, in improving outcomes for nondiabetic CKD patients. Future research should focus on refining existing QIs and expanding their validation to broader populations and healthcare settings.
sj-pdf-2-fla-10.1177_01427237211024221 – Supplemental material for Preschoolers’ imitation of sentential complement sentences: Does the nature of the matrix clause matter?
Creators: name: Morton, Ian
name: Schuele, C. Melanie
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: Education
subject: 200399 Language Studies not elsewhere classified
subject: FOS: Languages and literature
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-2-fla-10.1177_01427237211024221 for Preschoolers’ imitation of sentential complement sentences: Does the nature of the matrix clause matter? by Ian Morton and C. Melanie Schuele in First Language
Hypertension modifies the association between serum Klotho and chronic kidney disease in US adults with diabetes: a cross-sectional study of the NHANES 2007–2016
Creators: name: Hong, Tao
name: Lian, Zelong
name: Zhang, Chaojun
name: Zhang, Weihuang
name: Ye, Zhennan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The association between serum soluble Klotho (sKlotho) and chronic kidney disease (CKD) in individuals with diabetes mellitus (DM) remains controversial, and the influence of hypertension on this association is inconclusive. This study aims to investigate the joint association of sKlotho and hypertension with CKD prevalence in adults with DM. This cross-sectional study included 3,302 adults with DM from the National Health and Nutrition Examination Survey (2007–2016). Multivariate logistic regression analysis stratified by hypertension was used to assess the association between sKlotho and CKD prevalence. Moreover, the interaction between hypertension and sKlotho on CKD was evaluated. Among individuals with DM, a significant association between sKlotho levels and CKD prevalence was observed only in those with hypertension. CKD prevalence was significantly lower in individuals with high sKlotho (≥ 806 pg/mL) than in those with low sKlotho (< 806 pg/mL) [adjusted OR = 0.54 (95% CI: 0.41–0.72); p < 0.001]. Moreover, a significant interaction between hypertension and sKlotho on CKD prevalence was observed among adults with DM [Multiplicative scale: OR = 0.65 (95% CI: 0.42–0.99); RERI = −0.80 (95% CI: −1.49 to −0.10); AP = −0.51 (95% CI: −0.90 to −0.12); SI = 0.44 (95% CI: 0.30–0.66)]. Among DM adults, hypertension modified the association between sKlotho levels and CKD prevalence. Both additive and multiplicative interactions were observed between hypertension and sKlotho levels on CKD. The causalities between hypertension, Klotho, and CKD in diabetic patients need further exploration, and underlying mechanisms warrants elucidation.
Public interest in chronic kidney disease and dialysis: a 20-year data analysis
Creators: name: Arriola-Montenegro, Jose
name: Cheungpasitporn, Wisit
name: Thongprayoon, Charat
name: Craici, Iasmina M.
name: Miao, Jing
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Chronic kidney disease (CKD) is a growing global health challenge. As the disease progresses, it can lead to end-stage renal disease, necessitating dialysis or kidney transplantation. However, access to these life-saving treatments is often limited by geographic, financial, and resource constraints, underscoring the importance of public awareness and interest. This study examined global and U.S. search trends related to CKD and dialysis using Google Trends™ data from 2004 to 2024. Public search activity was measured using the Relative Search Interest (RSI) index, which ranges from 0 to 100. Both CKD and dialysis exhibited an upward trend in search activity worldwide and in the U.S., as indicated by a positive slope in linear regression analysis (all p < .0001), though some fluctuations and regional differences were observed. Pearson’s correlation analysis demonstrated a strong relationship between the U.S. dialysis RSI scores from Google Trends and real-world dialysis incidence rates from the United States Renal Data System (USRDS) (r = 0.961, p < .0001). Notably, in 2020, search activity for both CKD and dialysis declined, likely due to disruptions caused by the COVID-19 pandemic. The study highlights the potential of Google Trends as a valuable tool for assessing public interest and awareness of kidney health, providing insights that can inform public health strategies and educational initiatives. However, relying solely on Google Trends data to assess public interest is insufficient, due to inherent limitations and biases. Findings derived from search trends should be interpreted with caution and ideally supplemented with additional research methodologies.
Investigating the Borderlands of Historically Minoritized Graduate Students in Chemistry
Creators: name: Nardo, Jocelyn Elizabeth
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Other chemical sciences not elsewhere classified

description: My dissertation consists of three, interrelated papers that provided insight into the professional development of historically minoritized (hereafter, HM) graduate students within the discipline of chemistry. There was one overarching theoretical framework that situated the three papers together, but each paper has its own appropriate theoretical constructs and methodological organizations. The main data sources for this project consisted of 10 interviews with chemistry administration, staff, and faculty, 6 interviews with HM chemistry graduate students, 7 documents that are publicly available, and 55 assortments of researcher notes and reflections. The guiding question in the introduction described the overarching objectives of the study and was operationalized into specific research questions for each paper. To inform the study objectives, I asked the following guiding question:
How do the structures of the chemistry graduate program shape how HM graduate students learn to become chemistry professionals?
Epidemiological Data Management during an Outbreak of Ebola Virus Disease: Key Issues and Observations from Sierra Leone
Creators: name: Owada, Kei
name: Eckmanns, Tim
name: Kamara, Kande-Bure O’Bai
name: Olu, Olushayo Oluseun
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: epidemiology
subject: public health
subject: Ebola virus disease
subject: infectious disease outbreak
subject: surveillance system
subject: practice
subject: Sierra Leone
subject: perspective
subject: 610 Medizin

description: Sierra Leone experienced intense transmission of Ebola virus disease (EVD) from May 2014 to November 2015 during which a total of 8,704 confirmed cases and over 3,589 confirmed deaths were reported. Our field observation showed many issues in the EVD data management system, which may have contributed to the magnitude and long duration of the outbreak. In this perspective article, we explain the key issues with EVD data management in the field, and the resulting obstacles in analyzing key epidemiological indicators during the outbreak response work. Our observation showed that, during the latter part of the EVD outbreak, surveillance and data management improved at all levels in the country as compared to the earlier stage. We identified incomplete filling and late arrival of the case investigation forms at data management centers, difficulties in detecting double entries and merging identified double entries in the database, and lack of clear process of how death of confirmed cases in holding, treatment, and community care centers are reported to the data centers as some of challenges to effective data management. Furthermore, there was no consolidated database that captured and linked all data sources in a structured way. We propose development of a new application tool easily adaptable to new occurrences, regular data harmonization meetings between national and district data management teams, and establishment of a data quality audit system to assure good quality data as ways to improve EVD data management during future outbreaks.
Supplemental Material, sj-pdf-3-fnb-10.1177_03795721211011136 - Associations of Knowledge, Attitude, and Practices toward Anemia with Anemia Prevalence and Height-for-Age Z-Score among Indonesian Adolescent Girls
Creators: name: Rah, Jee Hyun
name: Melse-Boonstra, Alida
name: Agustina, Rina
name: van Zutphen, Kesso Gabrielle
name: Kraemer, Klaus
name: Wirawan, Fadila
name: Sadariskar, Arini A.
name: Setianingsing, Ainanur A.
name: Nadiya, Khairun
name: Prafiantini, Erfi
name: Asri, Eriana K.
name: Purwanti, Tutut S.
name: Kusyuniati, Sri
name: Karyadi, Elvina
name: Raut, Manoj K.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-3-fnb-10.1177_03795721211011136 for Associations of Knowledge, Attitude, and Practices toward Anemia with Anemia Prevalence and Height-for-Age Z-Score among Indonesian Adolescent Girls by Rina Agustina, Fadila Wirawan, Arini A. Sadariskar, Ainanur A. Setianingsing, Khairun Nadiya, Erfi Prafiantini, Eriana K. Asri, Tutut S. Purwanti, Sri Kusyuniati, Elvina Karyadi and Manoj K. Raut in Food and Nutrition Bulletin
Towards a framework for evaluating and grading evidence in public health
Creators: name: Harder, Thomas
name: Sin, Muna Abu
name: Bosch-Capblanch, Xavier
name: Coignard, Bruno
name: Gomes, Helena De Carvalho
name: Duclos, Phillippe
name: Eckmanns, Tim
name: Elder, Randy
name: Ellis, Simon
name: Forland, Frode
name: Garner, Paul
name: James, Roberta
name: Jansen, Andreas
name: Krause, Gérard
name: Lévy-Bruhl, Daniel
name: Morgan, Antony
name: Meerpohl, Joerg J.
name: Norris, Susan
name: Rehfuess, Eva
name: Sánchez-Vivar, Alex
name: Schünemann, Holger
name: Takla, Anja
name: Wichmann, Ole
name: Zingg, Walter
name: Zuiderent-Jerak, Teun
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Infectious diseases
subject: Public health
subject: GRADE
subject: Evidence-based health care
subject: PRECEPT
subject: 610 Medizin

description: The Project on a Framework for Rating Evidence in Public Health (PRECEPT) is an international collaboration of public health institutes and universities which has been funded by the European Centre for Disease Prevention and Control (ECDC) since 2012. Main objective is to define a framework for evaluating and grading evidence in the field of public health, with particular focus on infectious disease prevention and control. As part of the peer review process, an international expert meeting was held on 13–14 June 2013 in Berlin. Participants were members of the PRECEPT team and selected experts from national public health institutes, World Health Organization (WHO), and academic institutions. The aim of the meeting was to discuss the draft framework and its application to two examples from infectious disease prevention and control. This article introduces the draft PRECEPT framework and reports on the meeting, its structure, most relevant discussions and major conclusions.
Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression
Creators: name: Han, Zhaodi
name: Wang, Xinyu
name: Liu, Jing
name: Wang, Rui
name: Zhao, Wenyan
name: Liao, Hui
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Podocyte injury is a common pathologic mechanism in obesity-related glomerulopathy (ORG). Safflower injection (SFI), scientifically extracted and refined from safflower, is used to treat diabetic kidney disease according to clinical guideline. Our previous study confirmed that the main active compounds of SFI ameliorated high glucose-induced podocyte injury. It is uncertain whether SFI has an effect on ORG-related podocyte injury. This study aimed to explore the pharmacological effects and related mechanisms of SFI on podocyte injury of ORG mice. First, by combining ultra-high performance liquid chromatography tandem mass spectrometry analysis with online databases, the pathway enrichment, target-pathway analysis, and human protein–protein interaction network were conducted to discover the possible crucial mechanism of SFI against ORG. Then, ORG mice model was established by high-fat diet and biochemical assays, histopathology and western blot were used to explore the effects of SFI on obesity and podocyte injury. Finally, system pharmacology-based findings were evaluated in ORG mice. The results of system pharmacology suggested that SFI could alleviate ORG through insulin resistance (IR)-related pathway by regulating insulin receptor (INSR) and endothelial nitric oxide synthase (eNOS) expressions. The in vivo experiment confirmed that SFI ameliorated obesity, lipid metabolism-related indicators, podocyte injury of ORG mice. The mechanism relationships among IR, INSR, and eNOS were further verified in ORG mice. Our findings imply that by up-regulating the expression of renal INSR and eNOS, thereby inhibiting IR, SFI may be a promising candidate for the treatment of ORG.
Detection and Quantitation of Hazardous Chemicals in Environmental Matrices using Paper Spray Mass Spectrometry: Volume 2
Creators: name: Dowling, Sarah
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Forensic chemistry
Environmental biogeochemistry
Analytical chemistry not elsewhere classified

description: Paper spray mass spectrometry (PS-MS) is an ambient ionization technique that has been proven useful in many types of investigative analyses. However, the use of this technique with regards to environmental samples has been largely unexplored since the technique’s development. In this work, paper spray mass spectrometry was utilized to detect and quantify compounds for environmental, forensic and chemical defense applications. Due to the sensitive nature of some projects, the work was split into two volumes. Volume 1 focuses on the detection of pharmaceuticals in soil using paper spray (Chapter 2) and the detection of chemical warfare agent (CWA) simulants and CWA hydrolysis products (Chapter 3). Volume 2 focuses on the detection and quantitation of fentanyl analogs in environmental matrices. Chapter 5 focuses on the rapid analysis of fentanyl analogs in soil matrices. The following chapter evaluates the ability of PS-MS to detect low concentrations of fentanyl analogs in water (Chapter 6). Throughout this work, paper spray has proven to be an effective, rapid alternative to chromatography for the analysis of environmental samples.
Additional file 1 of β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
Creators: name: Halder, Sebok K.
name: Sapkota, Arjun
name: Milner, Richard
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1
sj-pdf-2-aph-10.1177_10105395211029803 – Supplemental material for Analysis of Periodontal Conditions in the Provinces of Vietnam: Results From the National Dental Survey
Creators: name: Minh, Nguyen Thi Hong
name: Cao Binh, Tran
name: Dinh Hai, Trinh
name: Thuy Duong, Nguyen
name: Bui, Quang-Thanh
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-2-aph-10.1177_10105395211029803 for Analysis of Periodontal Conditions in the Provinces of Vietnam: Results From the National Dental Survey by Nguyen Thi Hong Minh, Tran Cao Binh, Trinh Dinh Hai, Nguyen Thuy Duong and Quang-Thanh Bui in Asia Pacific Journal of Public Health
sj-pdf-1-nnr-10.1177_15459683211032967 – Supplemental Material for A Self-Empowered Upper Limb Repetitive Engagement Program to Improve Upper Limb Recovery Early Post-Stroke: Phase II Pilot Randomized Controlled Trial
Creators: name: Chin, Lay Fong
name: Hayward, Kathryn S.
name: Chai, Audrey Lik Ming
name: Brauer, Sandra G.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental Material, sj-pdf-1-nnr-10.1177_15459683211032967 for A Self-Empowered Upper Limb Repetitive Engagement Program to Improve Upper Limb Recovery Early Post-Stroke: Phase II Pilot Randomized Controlled Trial by Lay Fong Chin, Kathryn S. Hayward, Audrey Lik Ming Chai and Sandra G. Brauer in Neurorehabilitation and Neural Repair
Improving Ebola infection prevention and control in primary healthcare facilities in Sierra Leone: a single-group pretest post-test, mixed-methods study
Creators: name: Ratnayake, Ruwan
name: Ho, Lara S.
name: Ansumana, Rashid
name: Brown, Hannah
name: Borchert, Matthias
name: Miller, Laura
name: Kratz, Thomas
name: McMahon, Shannon A.
name: Sahr, Foday
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: 610 Medizin

description: Background: Accomplishing infection prevention and control (IPC) in health facilities in Sub-Saharan Africa is challenging. Owing to poor IPC, healthcare workers (HCWs) were frequently infected during Sierra Leone's Ebola epidemic. In late 2014, IPC was rapidly and nationally scaled up. We carried out workshops in sampled facilities to further improve adherence to IPC. We investigated HCW experiences and observed practice gaps, before and after the workshops. Methods: We conducted an uncontrolled, before and after, mixed-methods study in eight health facilities in Bo and Kenema Districts during December 2014 and January 2015. Quantitative methods administered to HCWs at baseline and follow-up included a survey on attitudes and self-efficacy towards IPC, and structured observations of behaviours. The intervention involved a workshop for HCWs to develop improvement plans for their facility. We analysed the changes between rounds in survey responses and behaviours. We used interviews to explore attitudes and self-efficacy throughout the study period. Results: HCWs described IPC as ‘life-saving’ and personal protective equipment (PPE) as uncomfortable for providers and frightening for patients. At baseline, self-efficacy was high (median=4/strongly agree). Responses reflecting unfavourable attitudes were low for glove use (median=1/strongly disagree, IQR, 1–2) and PPE use with ill family members (median=1, IQR, 1–2), and mixed for PPE use with ill HCWs (median=2/disagree, IQR, 1–4). Observations demonstrated consistent glove reuse and poor HCW handwashing. The maintenance of distance (RR 1.09, 95% CI 1.02 to 1.16) and patient handwashing (RR 1.19, 95% CI 1.3 to 1.25) improved to >90%. Conclusions: We found favourable attitudes towards IPC and gaps in practice. Risk perceptions of HCWs and tendencies to ration PPE where chronic supply chain issues normally lead to PPE stock-outs may affect practice. As Sierra Leone's Ebola Recovery Strategy aims to make all facilities IPC compliant, socio-behavioural improvements and a secure supply chain are essential.
Detection and Quantitation of Hazardous Chemicals in Environmental Matrices using Paper Spray Mass Spectrometry: Volume 1
Creators: name: Dowling, Sarah
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Forensic chemistry
Environmental biogeochemistry
Analytical chemistry not elsewhere classified

description: Paper spray mass spectrometry (PS-MS) is an ambient ionization technique that has been proven useful in many types of investigative analyses. However, the use of this technique with regards to environmental samples has been largely unexplored since the technique’s development. In this work, paper spray mass spectrometry was utilized to detect and quantify compounds for environmental, forensic and chemical defense applications. Due to the sensitive nature of some projects, the work was split into two volumes. Volume 1 focuses on the detection of pharmaceuticals in soil using paper spray (Chapter 2) and the detection of chemical warfare agent (CWA) simulants and CWA hydrolysis products (Chapter 3). Volume 2 focuses on the detection and quantitation of fentanyl analogs in environmental matrices. Chapter 5 focuses on the rapid analysis of fentanyl analogs in soil matrices. The following chapter evaluates the ability of PS-MS to detect low concentrations of fentanyl analogs in water (Chapter 6). Throughout this work, paper spray has proven to be an effective, rapid alternative to chromatography for the analysis of environmental samples.
Multi-regime Turbulent Combustion Modeling using Large Eddy Simulation/ Probability Density Function
Creators: name: Kashyap, Shashank Satyanarayana
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Aerodynamics (excl. hypersonic aerodynamics)
Aerospace engineering not elsewhere classified
Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics)

description: Combustion research is at the forefront of development of clean and efficient IC engines, gas turbines, rocket propulsion systems etc. With the advent of faster computers and parallel programming, computational studies of turbulent combustion is increasing rapidly. Many turbulent combustion models have been previously developed based on certain underlying assumptions. One of the major assumptions of the models is the regime it can be used for: either premixed or non-premixed combustion. However in reality, combustion systems are multi-regime in nature, i.e.,\ co-existence of premixed and non-premixed modes. Thus, there is a need for development of multi-regime combustion models which closely follows the physics of combustion phenomena. Much of previous modeling efforts for multi-regime combustion was done using flamelet-type models. As a first, the current study uses the highly robust transported Probability Density Function (PDF) method coupled with Large Eddy Simulation (LES) to develop a multi-regime model. The model performance is tested for Sydney Flame L, a piloted methane-air turbulent flame. The concept of flame index is used to detect the extent of premixed and non-premixed combustion modes. The drawbacks of using the traditional flame index definition in the context of PDF method are identified. Necessary refinements to this definition, which are based on the species gradient magnitudes, are proposed for the multi-regime model development. This results in identifying a new model parameter beta which defines a gradient threshold for the calculation of flame index. A parametric study is done to determine a suitable value for beta, using which the multi-regime model performance is assessed for Flame L by comparing it against the widely used non-premixed PDF model for three mixing models: Modified Curl (MCurl), Interaction by Exchange with Mean (IEM) and Euclidean Minimum Spanning Trees (EMST). The multi-regime model shows a significant improvement in prediction of mean scalar quantities compared to the non-premixed PDF model when MCurl mixing model is used. Similar improvements are observed in the multi-regime model when IEM and EMST mixing models are used. The results show potential foundation for further multi-regime model development using PDF model.
sj-docx-4-hol-10.1177_09596836211033197 – Supplemental material for Organic geochemical characterization of Early-Mid-Holocene swamp deposits near the Neolithic settlement in Yenikapı-Istanbul: Assessment of environmental variability and anthropogenic impacts
Creators: name: Yalçın, Mehmet Namık
name: Wilkes, Heinz
name: Plessen, Birgit
Publisher: name: SAGE Journals
Year: 2021
Subjects: Geography
History

description: Supplemental material, sj-docx-4-hol-10.1177_09596836211033197 for Organic geochemical characterization of Early-Mid-Holocene swamp deposits near the Neolithic settlement in Yenikapı-Istanbul: Assessment of environmental variability and anthropogenic impacts by Mehmet Namık Yalçın, Heinz Wilkes and Birgit Plessen in The Holocene
sj-docx-2-psp-10.1177_01461672211028141 – Supplemental material for On the Varieties of Diversity: Ideological Variations in Attitudes Toward, and Understandings of Diversity
Creators: name: Howard, Kathryn A.
name: Cervone, Daniel
name: Motyl, Matthew
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-2-psp-10.1177_01461672211028141 for On the Varieties of Diversity: Ideological Variations in Attitudes Toward, and Understandings of Diversity by Kathryn A. Howard, Daniel Cervone and Matthew Motyl in Personality and Social Psychology Bulletin
Detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in China
Creators: name: Wang, Bo
name: Yang, Xing-Lou
name: Li, Wen
name: Zhu, Yan
name: Ge, Xing-Yi
name: Zhang, Li-Biao
name: Zhang, Yun-Zhi
name: Bock, Claus-Thomas
name: Shi, Zheng-Li
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: Bat
subject: Natural reservoir
subject: Hepadnavirus
subject: Hepevirus
subject: Genome characterization
subject: 610 Medizin

description: Background: In recent years, novel hepadnaviruses, hepeviruses, hepatoviruses, and hepaciviruses have been discovered in various species of bat around the world, indicating that bats may act as natural reservoirs for these hepatitis viruses. In order to further assess the distribution of hepatitis viruses in bat populations in China, we tested the presence of these hepatitis viruses in our archived bat liver samples that originated from several bat species and various geographical regions in China. Methods: A total of 78 bat liver samples (involving two families, five genera, and 17 species of bat) were examined using nested or heminested reverse transcription PCR (RT-PCR) with degenerate primers. Full-length genomic sequences of two virus strains were sequenced followed by phylogenetic analyses. Results: Four samples were positive for hepadnavirus, only one was positive for hepevirus, and none of the samples were positive for hepatovirus or hepacivirus. The hepadnaviruses were discovered in the horseshoe bats, Rhinolophus sinicus and Rhinolophus affinis, and the hepevirus was found in the whiskered bat Myotis davidii. The full-length genomic sequences were determined for one of the two hepadnaviruses identified in R. sinicus (designated BtHBVRs3364) and the hepevirus (designated BtHEVMd2350). A sequence identity analysis indicated that BtHBVRs3364 had the highest degree of identity with a previously reported hepadnavirus from the roundleaf bat, Hipposideros pomona, from China, and BtHEVMd2350 had the highest degree of identity with a hepevirus found in the serotine bat, Eptesicus serotinus, from Germany, but it exhibited high levels of divergence at both the nucleotide and the amino acid levels. Conclusions: This is the first study to report that the Chinese horseshoe bat and the Chinese whiskered bat have been found to carry novel hepadnaviruses and a novel hepevirus, respectively. The discovery of BtHBVRs3364 further supports the significance of host switches evolution while opposing the co-evolutionary theory associated with hepadnaviruses. According to the latest criterion of the International Committee on Taxonomy of Viruses (ICTV), we hypothesize that BtHEVMd2350 represents an independent genotype within the species Orthohepevirus D of the family Hepeviridae.
Vegetable consumption among adults in Germany
Creators: name: Mensink, Gert
name: Schienkiewitz, Anja
name: Lange, Cornelia
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: ADULTS
subject: GERMANY
subject: HEALTH MONITORING
subject: VEGETABLES
subject: SURVEY
subject: 610 Medizin

description: Vegetables are part of a healthy diet and can help prevent various chronic diseases. According to the GEDA 2014/2015- EHIS study, 40.4% of women and 23.9% of men eat vegetables on a daily basis. The proportion of women who eat vegetables every day increases with age: from 31.9% of 18- to 29-year-olds to 48.3% of women aged 65 and above. Around one fifth of men under the age of 65 eat vegetables daily; this increases to 35.9% of men aged 65 or above. Across all age groups, women with higher levels of education are more likely to eat vegetables on a daily basis; the same can only be said about men in the 45 to 64 age group. Finally, women and men living in Saxony are most likely to eat vegetables every day; however, the differences between the federal states are marginal.
Machine Anomaly Detection using Sound Spectrogram Images and Neural Networks
Creators: name: Kim, Hanjun
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: Sound and vibration analysis is a prominent tool used for scientific investigations in various fields such as structural model identification or dynamic behavior studies. In manufacturing fields, the vibration signals collected through commercial sensors are utilized to monitor machine health, for sustainable and cost-effective manufacturing. Recently, the development of commercial sensors and computing environments have encouraged researchers to combine gathered data and Machine Learning (ML) techniques, which have been proven to be efficient for categorical classification problems. These discriminative algorithms have been successfully implemented in monitoring problems in factories, by simulating faulty situations. However, it is difficult to identify all the sources of anomalies in a real environment. In this paper, a Neural Network (NN) application on a KUKA KR6 robot arm is introduced, as a solution for the limitations described above. Specifically, the autoencoder architecture was implemented for anomaly detection, which does not require the predefinition of faulty signals in the training process. In addition, stethoscopes were utilized as alternative sensing tools as they are easy to handle, and they provide a cost-effective monitoring solution. To simulate the normal and abnormal conditions, different load levels were assigned at the end of the robot arm according to the load capacity. Sound signals were recorded from joints of the robot arm, then meaningful features were extracted from spectrograms of the sound signals. The features were utilized to train and test autoencoders. During the autoencoder process, reconstruction errors (REs) between the autoencoder’s input and output were computed. Since autoencoders were trained only with features corresponding to normal conditions, RE values corresponding to abnormal features tend to be higher than those of normal features. In each autoencoder, distributions of the RE values were compared to set a threshold, which distinguishes abnormal states from the normal states. As a result, it is suggested that the threshold of RE values can be utilized to determine the condition of the robot arm.
L'IMPORTANCE DE LA MOTIVATION DANS LE PROCESSUS DE L'ENSEIGNEMENT-APPRENTISSAGE DU FRANÇAIS LANGUE ETRANGERE A L'ECOLE : CAS DE L'ENS DE YAOUNDE 1
Creators: name: Georges Faustin Koumje
Publisher: name: Zenodo
Year: 2024

description: This article on the importance of motivation of learning French Language as a foreign language explores the different factors that motivate learners of French as a foreign language. We used the qualitative and quantitative research methodology in carrying out this research. A questionnaire was administered to a focus discussion group among the chosen samples. Results indicated that motivation stems from learners’ need to learn French as a means of having access to French-speaking regions or countries and platform for daily interactions. Other factors as our findings showed are instrumental, that is having a good mark and or using French in seeking employment. These instrumental motivations help learners’ progress, as each strives for the best. In sum, the research concludes that motivation in its different forms is the corner stone of the teaching and learning of French as a foreign language.
STRUCTURE-BASED DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1
Creators: name: Cardenas, Emilio Leal
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Organic chemistry not elsewhere classified

description: Alzheimer’s disease (AD) continues to plague the healthcare community as a serious healthcare crisis. Currently there fails to be an effective FDA approved drug that can treat the underlying mechanisms of the disease. Pathologically the disease is characterized by the accumulation of neurotoxic amyloid-b(Ab) plaques within a diseased patient’s brain. These plaques are widely accepted to be generated by the sequential proteolytic cleavage of amyloid precursor protein (APP) by b-secretase (BACE1, memapsin 2) and g-secretase. Numerous biochemical markers suggest that BACE1 is a viable target for AD drug development. Since the cloning and expression of BACE1 there has been an explosion of drug development efforts that have consisted of peptidomimetic-based and non-peptide-based inhibitors. These efforts have led to 13 BACE1 drug candidates some of which have made it to advanced stages of clinical trials. Unfortunately, an effective and tolerable BACE1 drug candidate continues to be rather elusive to the medicinal chemistry community. GRL-8234 is a potent BACE1 inhibitor that has been extensively shown to be tolerable during several short-term and long-term in vivo studies. The scaffold of GRL-8234 provides a suitable template for further lead development. Namely the P1’ 3-methoxy-benzylamine is of particular interest due to the advantageous interactions in the flap region of BACE1 that can be achieved by incorporation of substitution at the benzylic position. In the same way, the meta-substituent of the benzylamine P1’ ligand was investigated to probe the hydrophobic interactions in the S1’-S2’ binding pocket. A novel class of BACE1 inhibitors containing P1’ spirocyclic benzylamine derivatives were designed, synthesized and evaluated for their inhibitory activity against BACE1. In the process of preparing the aforementioned BACE1 inhibitors a method was established to be able to incorporate the desired 3,5-difluorophenyl methyl transition state isostere by utilizing an ester-derived Ti-enolate to access optically pure syn- and anti-aldol adducts as a key step. Additionally, a novel stereoselective method was established to afford heterospirocyclic benzylamines by utilizing a diastereoselective allyl grignard addition to optically pure a-silyloxy N-sulfinyl ketimines as a key step. Biological evaluation of these novel BACE1 inhibitors has been fruitful and continues to be ongoing.