cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sulforaphane induces SLPI secretion in the nasal mucosa
Creators: name: Meyer, Megan
name: Diaz-Sanchez, David
name: Kesic, Matthew J.
name: Jaspers, Ilona
name: Ho, Emily
name: Clarke, John
name: Noah, Terry L.
name: Simmen, Rosalia C.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Cells lining the respiratory tract are equipped with mechanisms that dampen the effects of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a mediator involved in regulating oxidative stress. Recent data indicate Nrf2 also controls expression of secretory leukocyte protease inhibitor (SLPI). Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, enhances Nrf2 activity. Therefore, we hypothesized that SFN supplementation induces SLPI secretion in the nasal mucosa in an Nrf2 dependent manner. Healthy nonsmoking adults ingested SFN-containing broccoli shake homogenate (BSH) for 3 consecutive days. Nasal lavage fluid (NLF) was collected before and after BSH ingestion and analyzed for SLPI protein levels. In follow up in vitro experiments, differentiated primary nasal epithelial cells were used to evaluate the relationship between SFN, Nrf2, and SLPI. Epithelial cells were transduced with Nrf2-specific shRNA to examine the regulatory role of Nrf2 on SLPI expression. Supplementation with BSH significantly increased SLPI levels in NLF. SFN supplementation in vitro significantly enhanced SLPI secretion and these effects were significantly decreased in cells transduced with Nrf2-specific shRNA.
The GOLEM: an ontology and knowledge graph for fiction and reader response
Creators: name: Pianzola, Federico
Publisher: name: Zenodo
Year: 2023
Subjects: computational literary studies
digital humanities
knowledge graph
formal ontology

description: This paper presents the first release of a graph database of online fiction corpora taken from various online sources in five different languages (English, Spanish, Italian, Indonesian, Korean). The goal is to describe texts using “derived data” (OECD, 2005) – or “mesodata” (Boot, 2009) – referring to various textual features, so that comparisons between documents could be done without accessing the full text of the documents. The idea is similar to that of the HathiTrust Extracted Features dataset (Jett et al., 2020), but the features encoded in the GOLEM project (“Graphs and Ontologies for Literary Evolution Models”) are much richer and also refer to narrative and stylistic elements and to reader response data (e.g. characters, relationships, topics, readability, sentiment of comments received by the story, etc.) (cf. Schöch et al., 2022; Pfeffer & Roth, 2019). During this presentation, I will show the challenges faced and the decision taken with respect to the following aspects: developing an ontology for stories and reader response, taking into account the perspectives of both researchers and the communities of online readers, as well as cultural and linguistic differences; extracting structured information about narrative features from the full text of the stories; linking information derived from the stories with information extracted from Wikidata and other fan wikis (e.g. fandom.com); legal and ethical issues related to copyright and personal data, including the licensing of the database for reuse by third parties; possible use cases of the knowledge graph to study changes in fiction over time (Pianzola et al. 2020). References Boot, P. (2009). Mesotext: Digitised Emblems, Modelled Annotations and Humanities Scholarship. Amsterdam University Press. Jett, J., Capitanu, B., Kudeki, D., Cole, T., Hu, Y., Organisciak, P., Underwood, T., Dickson Koehl, E., Dubnicek, R., & Downie, J. S. (2020). The HathiTrust Research Center Extracted Features Dataset (2.0) [Data set]. HathiTrust Research Center. https://doi.org/10.13012/R2TE-C227 OECD. (2005). Derived data element. In OECD Glossary of Statistical Terms. https://stats.oecd.org/glossary/detail.asp?ID=5130 Pfeffer, M., & Roth, M. (2019). Japanese Visual Media Graph: Providing researchers with data from enthusiast communities. Proc. Int’l Conf. on Dublin Core and Metadata Applications, 136–141. Pianzola, F., Acerbi, A., & Rebora, S. (2020). Cultural accumulation and improvement in online fan fiction. CHR 2020: Workshop on Computational Humanities Research, November 18–20, 2020, Amsterdam, The Netherlands, 2723, 2–11. http://ceur-ws.org/Vol-2723/short8.pdf Schöch, C., Hinzmann, M., Röttgermann, J., Dietz, K., & Klee, A. (2022). Smart Modelling for Literary History. International Journal of Humanities and Arts Computing, 16(1), 78–93. https://doi.org/10.3366/ijhac.2022.0278
Kinematics and Host-Galaxy Properties Suggest a Nuclear Origin for Calcium-Rich Supernova Progenitors
Creators: name: Foley, Ryan J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Calcium-rich supernovae (Ca-rich SNe) are peculiar low-luminosity SNe Ib with relatively strong Ca spectral lines at ~2 months after peak brightness. This class also has an extended projected offset distribution, with several members of the class offset from their host galaxies by 30 - 150 kpc. There is no indication of any stellar population at the SN positions. Using a sample of 13 Ca-rich SNe, we present kinematic evidence that the progenitors of Ca-rich SNe originate near the centers of their host galaxies and are kicked to the locations of the SN explosions. Specifically, SNe with small projected offsets have large line-of-sight velocity shifts as determined by nebular lines, while those with large projected offsets have no significant velocity shifts. Therefore, the velocity shifts must not be primarily the result of the SN explosion. There is an excess of SNe with blueshifted velocity shifts within two isophotal radii (5/6 SNe), indicating that the SNe are moving away from their host galaxies and redshifted SNe on the far sides of their galaxies are selectively missed in SN surveys. Additionally, nearly every Ca-rich SN is hosted by a galaxy with indications of a recent merger and/or is in a dense environment. We propose a progenitor model which fits all current data: The progenitor system for a Ca-rich SN is a double white dwarf (WD) system where at least one WD has a significant He abundance. This system, through an interaction with a super-massive black hole (SMBH) is ejected from its host galaxy and the binary is hardened, significantly reducing the merger time. After 10 - 100 Myr (on average), the system explodes with a large physical offset. The rate for such events is significantly enhanced for galaxies which have undergone recent mergers, potentially making Ca-rich SNe new probes of both the galaxy merger rate and (binary) SMBH population. (abridged)
description: 16 pages, 12 pages, submitted to MNRAS
Movements Improvements from Bimanual Interactive Training Post-Stroke
Creators: name: Verardi, Martina
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Artificially augmenting error during therapeutic training has shown promise in some recent studies. Here was explored visual error augmentation using a visual distortion that instantaneously shifts the subject’s cursor in the direction of error. 29 chronic stroke survivors were asked to practice a bimanual reaching task for approximately 40 minutes, for three weeks. The primary outcome of the study was Fugl-Meyer. Results show that the change in the mean values for the group who received the error augmentation between pre-evaluation and post-evaluation is 2.80, while between pre-evaluation and follow-up is 1.47. Even if both are below the minimal clinical importance difference of the scale, 5.6, results seem promising. Other kinematic outcomes were examined, such as range of motion deficit, asymmetry in the top-down direction, and the average movement time. All these three metrics were added together to obtain a composite error metric. Results show that the change in the mean values for the group who received the error augmentation between pre-evaluation and post-evaluation is -15.05, while between pre-evaluation and follow-up is -11.82. Because this is an error metric if the values are more negative, then the subject is improving. Such automated touch-free therapy may prove compelling because such approaches can reduce the expenses and complexity of using a robot while providing additional therapeutic support during arm rehabilitation, but further studies are necessary to highlight the benefit of the visual error augmentation without any haptic feedback and also the possible profiles of patients who can most benefit.
Predictions for Observing Protostellar Outflows with ALMA
Creators: name: Bradshaw, C.
name: Offner, S. S. R.
name: Arce, H. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Protostellar outflows provide a means to probe the accretion process of forming stars and their ability to inject energy into their surroundings. However, conclusions based on outflow observations depend upon the degree of accuracy with which their properties can be estimated. We examine the quality of Atacama Large Millimeter/submillimeter Array (ALMA) observations of protostellar outflows by producing synthetic $^{12}$CO(1-0) and $^{13}$CO(1-0) observations of numerical simulations. We use various ALMA configurations, observational parameters, and outflow inclinations to assess how accurately different assumptions and setups can recover underlying properties. We find that more compact arrays and longer observing times can improve the mass and momentum recovery by a factor of two. During the first $\sim$0.3 Myr of evolution, $^{12}$CO(1-0) is optically thick, even for velocities $|v|\ge 1$ km s$^{-1}$, and outflow mass is severely underestimated without an optical depth correction. Likewise, $^{13}$CO(1-0) is optically thick during the first $\simeq 0.1$ Myr. However, underestimation due to shorter observing time, missing flux, and optical depth are partially offset by the assumption of local thermodynamic equilibrium and higher excitation temperatures. Overall, we expect that full ALMA $^{13}$CO(1-0) observations of protostellar sources within 500 pc with observing times $\gtrsim 1$ hrs and assumed excitation temperatures of $T<20$K will reliably measure mass and line-of-sight momentum to within 20\%.
description: 13 pages, 14 figures, accepted to ApJ
Promising alternative settings for HPV vaccination of US adolescents
Creators: name: Shah, Parth D
name: Gilkey, Melissa B
name: Gottlieb, Sami L
name: Pepper, Jessica K
name: Brewer, Noel T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Vaccination in alternative settings, defined here as being outside of traditional primary care, can help address the pressing public health problem of low human papillomavirus vaccine coverage among adolescents in the United States. Pharmacies are promising because they are highly accessible and have well established immunization practices. However, pharmacies currently face policy and reimbursement challenges. School-located mass vaccination programs are also promising because of their high reach and demonstrated success in providing other vaccines, but control by local policymakers and challenges in establishing community partnerships complicate widespread implementation. Health centers in schools are currently too few to greatly increase access to human papillomavirus vaccine. Specialty clinics have experience with vaccination, but the older age of their patient populations limits their reach. Future steps to making alternative settings a success include expanding their use of statewide vaccine registries and improving their coordination with primary care providers.
The Role of Mindfulness in Positive Reappraisal
Creators: name: Gaylord, Susan
name: Park, Jongbae
name: Garland, Eric
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Mindfulness meditation is increasingly well known for therapeutic efficacy in a variety of illnesses and conditions, but its mechanism of action is still under debate in scientific circles. In this paper we propose a hypothetical causal model that argues for the role of mindfulness in positive reappraisal coping. Positive reappraisal is a critical component of meaning-based coping that enables individuals to adapt successfully to stressful life events. Mindfulness, as a metacognitive form of awareness, involves the process of decentering, a shifting of cognitive sets that enables alternate appraisals of life events. We review the concept of positive reappraisal in transactional stress and coping theory; then describe research and traditional literature related to mindfulness and cognitive reappraisal, and detail the central role of mindfulness in the reappraisal process. With this understanding, we present a causal model explicating the proposed mechanism. The discussion has implications for clinical practice, suggesting how mindfulness-based integrative medicine interventions can be designed to support adaptive coping processes.
In vivo ureteroscopic intrarenal pressures and clinical outcomes: a multi-institutional analysis of 120 consecutive patients
Creators: name: Croghan, Stefanie M.
name: Cunnane, Eoghan
name: O’Meara, Sorcha
name: Muheilan, Muheilan
name: Cunnane, Connor
name: Patterson, Kenneth
name: Skolarikos, Andreas
name: Somani, Bhaskar
name: Jack, Gregory S
name: Forde, James C.
name: O’Brien, Fergal J
name: WALSH, MICHAEL
name: Manecksha, Rustom P
name: McGuire, Barry B
name: F. Davis, Niall
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 40
subject: Engineering
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Objectives To evaluate the pressure range generated in the human renal collecting system during ureteroscopy (URS), in a large patient sample, and to investigate a relationship between intrarenal pressure (IRP) and outcome. Patients and Methods A prospective multi-institutional study was conducted, with ethics board approval; February 2022–March 2023. Recruitment was of 120 consecutive consenting adult patients undergoing semi-rigid URS and/or flexible ureterorenoscopy (FURS) for urolithiasis or diagnostic purposes. Retrograde, fluoroscopy-guided insertion of a 0.036-cm (0.014″) pressure guidewire (COMET™ II, Boston Scientific, Marlborough, MA, USA) to the renal pelvis was performed. Baseline and continuous ureteroscopic IRP was recorded, alongside relevant operative variables. A 30-day follow-up was completed. Descriptive statistics were applied to IRP traces, with mean (sd) and maximum values and variance reported. Relationships between IRP and technical variables, and IRP and clinical outcome were interrogated using the chi-square test and independent samples t-test. Results A total of 430 pressure traces were analysed from 120 patient episodes. The mean (sd) baseline IRP was 16.45 (5.99) mmHg and the intraoperative IRP varied by technique. The mean (sd) IRP during semi-rigid URS with gravity irrigation was 34.93 (11.66) mmHg. FURS resulted in variable IRP values: from a mean (sd) of 26.78 (5.84) mmHg (gravity irrigation; 12/14-F ureteric access sheath [UAS]) to 87.27 (66.85) mmHg (200 mmHg pressurised-bag irrigation; 11/13-F UAS). The highest single pressure peak was 334.2 mmHg, during retrograde pyelography. Six patients (5%) developed postoperative urosepsis; these patients had significantly higher IRPs during FURS (mean [sd] 81.7 [49.52] mmHg) than controls (38.53 [22.6] mmHg; P < 0.001). Conclusions A dynamic IRP profile is observed during human in vivo URS, with IRP frequently exceeding expected thresholds. A relationship appears to exist between elevated IRP and postoperative urosepsis.
Effective rates from thermodynamically consistent coarse-graining of models for molecular motors with probe particles
Creators: name: Zimmermann, Eva
name: Seifert, Udo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Many single molecule experiments for molecular motors comprise not only the motor but also large probe particles coupled to it. The theoretical analysis of these assays, however, often takes into account only the degrees of freedom representing the motor. We present a coarse-graining method that maps a model comprising two coupled degrees of freedom which represent motor and probe particle to such an effective one-particle model by eliminating the dynamics of the probe particle in a thermodynamically and dynamically consistent way. The coarse-grained rates obey a local detailed balance condition and reproduce the net currents. Moreover, the average entropy production as well as the thermodynamic efficiency is invariant under this coarse-graining procedure. Our analysis reveals that only by assuming unrealistically fast probe particles, the coarse-grained transition rates coincide with the transition rates of the traditionally used one-particle motor models. Additionally, we find that for multicyclic motors the stall force can depend on the probe size. We apply this coarse-graining method to specific case studies of the F1-ATPase and the kinesin motor.
description: Phys. Rev. E, in press
A relational description of higher commutators in Mal'cev varieties
Creators: name: Opršal, Jakub
Publisher: name: arXiv
Year: 2014
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 08A40

description: We give a relational description of higher commutator operators, which were introduced by Bulatov, in varieties with a Mal'cev term. Furthermore, we use this result to prove that for every algebra with a Mal'cev term there exists a largest clone on the same underlying set containing the Mal'cev operation and having the same congruence lattice and the same higher commutator operators as the original algebra. A local variant of this theorem is given.
SI for Dispersion and mixing dynamics of bilgewater emulsions in Taylor Couette flows
Creators: name: Panwar, Vishal
name: Varga, Cassandra N.
name: Dutcher, Cari S.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: 91504 Fluidisation and Fluid Mechanics
subject: FOS: Other engineering and technologies

description: Mass transfer results for the 10 mM NaCl systems
title: e-Forschungsberichte, Faszikel 2 (2022)
title: Research E-Papers, Faszikel 2 (2022)
title: Faszikel 2 (2022)
titleType: AlternativeTitle
Creators: name: Deutsches Archäologisches Institut
Publisher: name: Deutsches Archäologisches Institut
Year: 2022

description: Frankfurt am Main, Deutschland. ClaReNet. Klassifikation und Repräsentation keltischer Münzprägungen im Netz. Das Projekt von 2021 bis 2024...§ 1–21 Athen, Griechenland. Forschungen im Rahmen des Projektes »Shapes of Ancient Greece«: Das Fragment einer spätgeometrischen Riesenamphora. Arbeiten im Jahr 2022...§ 1–12 Olympia, Griechenland. Die Geschichte der Ausgrabung in der III. und IV. Kampagne. Eine digitale Rekonstruktion in iDAI.field. Die Arbeiten des Jahres 2021...§ 1–21 Uruk, Irak. Wissenschaftliche Forschungen und Konservierungsarbeiten. Die Arbeiten der Jahre 2020 bis 2022...§ 1–31 Kal-e Chendar/Shami, Iran. Ein ungehobener Schatz hellenistischer Plastik aus der Elymais. Die Arbeiten des Jahres 2021...§ 1–26 Tabrīz, Iran. Ilkhanid Tabrīz. Architectural and Archaeological Research on the Rabʿi Rashīdī. Season 2019...§ 1–35 Selinunt, Italien. Forschungen in Selinunt, Teil 2. Die Arbeiten der Jahre 2020 und 2021...§ 1–26 Sevilla, Spain. The chalcolithic mega-site of Valencina de la Concepción (Sevilla), Spain. Results of the fieldwork from 2018 to 2020...§ 1–25 Meroë, Sudan. Site Management und Konservierung durch Ausbildung. Capacity Building in den Jahren 2020 und 2021...§ 1–13 Boğazköy, Türkei. Die kaiserzeitlichen Strukturen in der nördlichen Unterstadt von Boğazköy. Erste Ergebnisse der Arbeiten von 2019 bis 2021...§ 1–15 Didyma, Turkey. Archaeometric analyses of ceramics from excavations in Didyma. Season 2021...§ 1–21 Istanbul, Türkei. Reliquientranslationen und die Konstruktion einer christlichen Sakraltopographie für Konstantinopel vom 4. bis zum 7. Jahrhundert. Die Arbeiten der Jahre 2020 und 2021...§ 1–9 Karien, Türkei. Zur Reflexion der ptolemäischen Herrschaft in der karischen Münzprägung. Die Arbeiten des Jahres 2020...§ 1–23 Pergamon, Turkey. Monument Conservation and Capacity Building. The work of 2020 and 2021...§ 1–18 Pergamon, Türkei. Pergamon. Die Arbeiten des Jahres 2021...§ 1–48
Prescription of atropine eye drops among children diagnosed with myopia in Taiwan from 2000 to 2007: a nationwide study
Creators: name: Liu, T-L
name: Lin, P-J
name: Pu, C
name: Fang, Y-T
name: Chou, P
name: Huang, N
name: Chou, Y-J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: This study was conducted to examine the atropine eye drop prescription trend for children diagnosed with myopia, and to determine the factors associated with the prescription of atropine eye drops.
Modeling Components of Lumbar Spine Using an Optimization Algorithm Developed for Passive Exoskeletons
Creators: name: Marconi, Francesco
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: This work describes a rst attempt to model the passive components of the lumbar spine during a simple movement of lateral bending. This approach adopts an adapted version of an algorithm that was developed for the design of a passive exoskeleton for the rehabilitation of upper and lower limbs. The aim of this work is to assess the capability of this approach to deal with more complex structures. This approach is structured in two sections: the rst one deals with the design of a human lumbar spine by integrating geometrical data taken from literature with intervertebral joint angles measured on human lumbar spines. In particular, the model is composed by 3D images of lumbar vertebrae obtained from CT scans performed on cadaver specimens while their orientation is given by values of intervertebral angles measured on healthy patients. In order to properly arrange all the vertebrae in the space, geometrical assumptions have been considered and implemented. The second part of the work focuses on the algorithm cited above; in particular, it describes the di erences respect to the original one and its implementation to the virtual lumbar spine. Instead of having elements that are simpli ed as beams that perform movements in a plane, the algorithm deals with the morphologies of the vertebrae that are moving in space. Therefore, the developed code has been structured in order to arrange a network of linear springs for each functional spinal unit; these elastic elements would represent passive tissues such as intervertebral discs and ligaments. For each pair of vertebrae, the algorithm tunes the characteristics of these springs in order to guarantee the torque equilibrium with respect to external loads that are acting on the vertebral body centroid of the upper vertebra; indeed, this is able to rotate around a spherical joint placed between the lower endplate of the upper vertebra and the upper endplate of the lower vertebra. The results show that this is a theoretical framework that could be used to apply the Exonet as an hypotetical assistive device
Ricci tensor on ${\rm RCD}^*(K,N)$ spaces
Creators: name: Han, Bang-Xian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: We obtain an improved Bochner inequality based on the curvature-dimension condition ${\rm RCD}^*(K,N)$ and propose a definition of $N$-dimensional Ricci tensor on metric measure spaces.
Integer-Programming Ensemble of Temporal-Relations Classifiers
Creators: name: Kerr, Catherine
name: Hoare, Terri
name: Carroll, Paula
name: Marecek, Jakub
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The extraction and understanding of temporal events and their relations are major challenges in natural language processing. Processing text on a sentence-by-sentence or expression-by-expression basis often fails, in part due to the challenge of capturing the global consistency of the text. We present an ensemble method, which reconciles the outputs of multiple classifiers of temporal expressions across the text using integer programming. Computational experiments show that the ensemble improves upon the best individual results from two recent challenges, SemEval-2013 TempEval-3 (Temporal Annotation) and SemEval-2016 Task 12 (Clinical TempEval).
Market Analysis Brazil: BUS 17
Creators: name: Market Analysis
Publisher: name: Roper Center for Public Opinion Research
Year: 2023

description: Household appliances (9); household employee (1); social status (1); access to computer/phone (6); most important issue (2); current/future status of Brazil's economy (2); personal financial situation (4); vote in previous presidential election (1); vote in previous gubernatorial election (1); rating of presidential candidates (1); relate to a political party (2); ideological placement (1); President Lula performance (2); support for US policies (1); economic initiatives (1); daily habits (1); personal values (1); job satisfaction (1).
On the robustness of topological quantum codes: Ising perturbation
Creators: name: Zarei, Mohammad Hossein
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the phase transition from two different topological phases to the ferromagnetic phase by focusing on points of the phase transition. To this end, we present a detailed mapping from such models to the Ising model in a transverse field. Such a mapping is derived by re-writing the initial Hamiltonian in a new basis so that the final model in such a basis has a well-known approximated phase transition point. Specifically, we consider the toric codes and the color codes on some various lattices with Ising perturbation. Our results provide a useful table to compare the robustness of the topological codes and to explicitly show that the robustness of the topological codes depends on triangulation of their underlying lattices.
description: 15 pages, 12 figures, 1 table, Accepted for publication in Physical Review A
Understanding the Effects of Movement-Based Priming on Neuroplasticity and Motor Control in Stroke
Creators: name: Lim, Hyosok
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: The purpose of this dissertation was to examine the effects of movement-based priming on neuroplasticity and motor control in stroke survivors. Specifically, this dissertation examined whether movement-based priming using the paretic or non-paretic lower limb enhanced corticomotor activity and paretic lower limb motor control in stroke survivors. The rationale for this dissertation derived from the recent impactful perspective suggesting that people with mild stroke impairment may improve paretic limb motor recovery utilizing the interhemispheric competition model (facilitating the lesioned motor cortex) while people with severe stroke may benefit from the vicariation model (facilitating the non-lesioned motor cortex). We first investigated the effects of movement-based priming using the paretic lower limb with gaming technology on corticomotor excitability of the paretic TA and paretic ankle motor control in people with chronic stroke. We demonstrated that the short-term paretic limb movement priming increased corticomotor excitability of the paretic TA, however the ankle motor control did not change. This study establishes the use of paretic limb movement of the lower limb as a priming approach in relatively less impaired chronic stroke survivors. Also, we examined the effects of movement-based priming using the non-paretic lower limb on neurophysiological outcomes and paretic ankle motor control in severely impaired stroke survivors. We found that the contralateral corticomotor excitability of the non-paretic TA increased after non-paretic skill- and strength-based movement priming. Ipsilateral connectivity from the non-lesioned hemisphere to the paretic TA and TCI from the non-lesioned to lesioned hemisphere increased after skill priming while strength priming did not show any changes for ipsilateral connectivity and TCI. Also, reaction time of the paretic TA improved after skill and strength priming tasks using the non-paretic limb. The study finding suggests the non-paretic lower limb movements as an alternative cortical priming approach for those with severe impairment in the paretic limb and enhances our understanding on the role of non-lesioned M1 to promote lower limb neuroplasticity and motor recovery in severe stroke. Findings from this dissertation may provide useful information to develop targeted rehabilitation approaches for individuals post stroke with different impairment levels.
Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer
Creators: name: Salinas, Claudia A.
name: Isaacs, William B.
name: Xu, Jianfeng
name: Tembe, Waibov A.
name: Stoffel, Elena M.
name: Robbins, Christiane M.
name: Carpten, John D.
name: Lange, Ethan M.
name: Johnson, Anna M.
name: Zuhlke, Kimberly A.
name: Okoth, Linda A.
name: Zheng, S. Lilly
name: Cooney, Kathleen A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Nibrin (NBN), located on chromosome 8q21 is a gene involved in DNA double-strand break repair that has been implicated in the rare autosomal recessive chromosomal instability syndrome known as Nijmegen Breakage Syndrome. NBS is characterized by specific physical characteristics (microcephaly and dysmorphic facies), immunodeficiency, and increased risk of malignancy. Individuals who are heterozygous for NBN mutations are clinically asymptomatic, but may display an elevated risk for certain cancers including, but not limited to, ovarian and prostate cancer as well as various lymphoid malignancies. In this study, 94 unrelated familial prostate cancer cases from the University of Michigan Prostate Cancer Genetics Project (n= 54) and Johns Hopkins University (n=40) were subjected to targeted next-generation sequencing of the exons, including UTRs, of NBN. One individual of European descent, diagnosed with prostate cancer at age 52, was identified to have a heterozygous 2117 C>G mutation in exon 14 of the gene, that results in a premature stop at codon 706 (S706X). Sequencing of germline DNA from additional male relatives showed partial co-segregation of the NBN S706X mutation with prostate cancer. This NBN mutation was not observed among 2768 unrelated European men (1859 with prostate cancer and 909 controls). NBN is involved in double-strand break repair as a component of the MRE11 (meiotic recombination 11)/RAD50/NBN genomic stability complex. The S706X mutation truncates the protein in a highly conserved region of NBN near the MRE11 binding site, thus suggesting a role for rare NBN mutations in prostate cancer susceptibility.
Effective equidistribution for some unipotent flows in $PSL(2, \mathbb{R})^k$ mod cocompact, irreducible lattice
Creators: name: Tanis, James
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37A17, 37A05, 47A67

description: Let $d \geq 2$, and let $Γ\subset PSL(2, \mathbb{R})^d$ be an irreducible, cocompact lattice. We prove a sharp estimate up to a logarithmic factor on the rate of equidistribution of coordinate horocycle flows on $Γ\backslash PSL(2, \mathbb{R})^d$.
description: 12 pages. This is part of an expanded paper titled "Exponential multiple mixing for some partially hyperbolic flows on products of $PSL(2,\mathbb{R}$)," published in DCDS - A, 2018, 38 (3) : 989-1006
Graphs and Ontologies for Literary Evolution Models (GOLEM)
Creators: name: Pianzola, Federico
Publisher: name: Zenodo
Year: 2023
Subjects: computational literary studies
cultural evolution
digital humanities
knowledge graph
fiction

description: Stories are a crucial element of our evolutionary legacy (Boyd 2009; Gottschall 2012), they are instruments that help us organize our experiences, develop mind reading, and enhance emotional attunement (Herman 2003; Zunshine 2006; Mar and Oatley 2008). Given their utmost importance for human beings, in order to better understand the specific beneficial effects that stories can have, we need to study how they evolved, adapting to different societies and cultures. The evolution of fictional storytelling goes beyond literary history, having its roots in oral performance and having developed into audiovisual and interactive narrative forms (e.g. films and video games). However, despite this long trajectory, we know very little of how fiction evolves. Online fiction allows us to collect thousands of data points about readers’ response to a text, in the form of comments to paragraphs (e.g. Wattpad) or chapters (e.g. the Archive of Our Own), ratings, and book reviews (e.g. Goodreads). Thanks to online fiction, we can design robust experiments for the study of readers’ thoughts and emotions and the text that elicited them. GOLEM will be the first large-scale project studying the evolution of fiction and its effects, using data available thanks to digital and social media.
Supersymmetry of IIA warped flux AdS and flat backgrounds
Creators: name: Beck, S.
name: Gutowski, J. B.
name: Papadopoulos, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We identify the fractions of supersymmetry preserved by the most general warped flux AdS and flat backgrounds in both massive and standard IIA supergravities. We find that $AdS_n\times_w M^{10-n}$ preserve $2^{[{n\over2}]} k$ for $n\leq 4$ and $2^{[{n\over2}]+1} k$ for $40}$. In addition we show that, for suitably restricted fields and $M^{10-n}$, the killing spinors of AdS backgrounds are given in terms of the zero modes of Dirac like operators on $M^{10-n}$. This generalizes the Lichnerowicz theorem for connections whose holonomy is included in a general linear group. We also adapt our results to $\bR^{1,n-1}\times_w M^{10-n}$ backgrounds which underpin flux compactifications to $\bR^{1,n-1}$ and show that these preserve $2^{[{n\over2}]} k$ for $2
description: 44 pages
Карпатський годограф P- и S-волн и неоднородности литосферы
Creators: name: Kutas, R I
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 370609
subject: Seismology and seismic exploration

description: Карпатський годограф P- и S-волн и неоднородности литосферы
On terminal Fano 3-folds with 2-torus action
Creators: name: Bechtold, Benjamin
name: Huggenberger, Elaine
name: Hausen, Juergen
name: Nicolussi, Michele
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14J45, 14J30, 14L30

description: We classify the terminal Fano threefolds of Picard number one that come with an effective action of a two-torus. Our approach applies also to higher dimensions and generalizes the correspondence between toric Fano varieties and lattice polytopes: to any Fano variety with a complete intersection Cox ring we associate its "anti canonical complex", which is a certain polyhedral complex living in the lattice of one parameter groups of an ambient toric variety. For resolutions constructed via the tropical variety, the lattice points inside the anticanonical complex control the discrepancies. This leads, for example, to simple characterizations of terminality and canonicity.
description: missing items in the classification list added, other corrections
Study of Synaptic Function in Galactosyl-Ceramidase Deficient Mice
Creators: name: Rebiai, Rima
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Synaptic failure is a major contributor to cognitive impairment in many neurological diseases. Krabbe disease (KD) is a lysosomal deficiency of galactosyl-ceramidase (GALC) that causes toxic accumulation of psychosine and global demyelination. KD patients develop major motor problems and become neurologically compromised. It is unknown whether synaptic function is also affected by the deficiency of GALC. Because psychosine is a lipid that disrupts the normal architecture of the membrane, altering associated signaling, we hypothesized that synaptic function is also impaired in KD. Using Golgi Cox staining, we found a significant decrease in the number of dendritic spines in cortical neurons of sick twitcher mice, the authentic murine model of infantile KD. Electron microscopy data confirmed ultrastructural alterations in many KD synapses in the cortex as well as in the hippocampus, with reduced contact area and lower number of synaptic vesicles. Levels of psychosine were elevated in synaptic membranes, in parallel with altered levels of several pre-synaptic SNARE proteins. Paired pulse facilitation was significantly reduced in hippocampal neurons of sick twitcher mice, as well as in additional mutants bearing other GALC mutations. Furthermore, conditional ablation of GALC in neurons but not in oligodendrocytes confirmed intrinsic deficits of synaptic transmission, independent from myelin defects. Together, these results support our hypothesis that KD synapses are structurally and functionally disrupted and provide a basis to understand neurological deficits observed in KD patients.
Classifiers
Creators: name: , Ying
Publisher: name: Zenodo
Year: 2023

description: The resource contains trained models, the pre-processed dataset, and all train logs of our results in the NLBSE2023 Tool Competition. In addition, the files are zipped separately for each classifier. all_train_log.tar.gz: all training logs final_final_dataset.tar.gz: the preprocessed dataset unzip the zip file: checkpoint-best-ppl: the best model on the validation dataset checkpoint-last: the last model in the training. We used it to test the testing dataset to calculate the precision, recall, fscore recorded in the paper. the dev.gold is the ground truth of the validation dataset; the dev.output is the ground truth of the validation dataset in the trainning stage. the test_0.gold is the ground truth of the validation dataset; the test_0.output is the ground truth of the validation dataset in the testing stage. the test_1.gold is the ground truth of the testing dataset; the test_1.output is the prediction of our classifier.
Konflikte und Kontroversen in und um Statistik
Creators: name: Weiß, Christel
Publisher: name: Heidelberger Jahrbücher Online
Year: 2023

description: Die Statistik als eigenständige wissenschaftliche Disziplin und als angewandte Wissenschaft bietet Potenzial für vielerlei Kontroversen. Dieser Beitrag beleuchtet Konflikte, die wegen Statistik entstehen, auf mehreren Ebenen. Zunächst wird dargelegt, dass zwischen Statistikern interkollegiale Divergenzen und Meinungsverschiedenheiten wahrnehmbar sind – sei es wegen Streitigkeiten um Begriffe, wegen unterschiedlicher Vorstellungen bei der Durchführung analytischer Methoden oder bezüglich der Anwendungen von Statistik. Zudem wird darauf eingegangen, wie Statistiker bei der Datenanalyse Konflikte mit Kollegen anderer Fachrichtungen und mit sich selbst austragen – beginnend bei der Studienplanung über die Datenanalyse bis hin zur Interpretation der Ergebnisse. Schließlich wird anhand einiger konkreter Anwendungsbeispiele aufgezeigt, dass Statistik auch gesellschaftlicher Sprengstoff sein kann und Meinungsverschiedenheiten wegen Statistik nicht nur im akademischen Umfeld auftreten.
description: Heidelberger Jahrbücher Online, Bd. 8 (2023): Krieg, Konflikt, Solidarität
High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry
Creators: name: Young, Joanne P.
name: Jenkins, Mark A.
name: Win, Aung Ko
name: Winship, Ingrid
name: Lindor, Noralane M.
name: Mundt, Erin
name: Pollett, Aaron
name: Pearson, Sally
name: Buchanan, Daniel D.
name: Thibodeau, Stephen N.
name: Walsh, Michael D.
name: Nagler, Belinda N.
name: Crawford, William J.
name: Rosty, Christophe
name: Walters, Rhiannon J.
name: Baron, John A.
name: Hopper, John L.
name: Gallinger, Steven
name: Aronson, Melyssa
name: Clendenning, Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The question of whether prostate cancer is part of the Lynch syndrome spectrum of tumors is unresolved. We investigated the mismatch repair (MMR) status and pathologic features of prostate cancers diagnosed in MMR gene mutation carriers. Prostate cancers (mean age at diagnosis = 62 ± SD = 8 years) from 32 MMR mutation carriers (23 MSH2, 5 MLH1 and 4 MSH6) enrolled in the Australasian, Mayo Clinic and Ontario sites of the Colon Cancer Family Registry were examined for clinico-pathologic features and MMR-deficiency (immunohistochemical loss of MMR protein expression and high levels of microsatellite instability; MSI-H). Tumor MMR-deficiency was observed for 22 cases [69 %; 95 % confidence interval (CI) 50–83 %], with the highest prevalence of MMR-deficiency in tumors from MSH2 mutation carriers (19/23, 83 %) compared with MLH1 and MSH6 carriers combined (3/9, 33 %; p = 0.01). MMR-deficient tumors had increased levels of tumor infiltrating lymphocytes compared with tumors without MMR-deficiency (p = 0.04). Under the assumption that tumour MMR-deficiency occurred only because the cancer was caused by the germline mutation, mutation carriers are at 3.2-fold (95 % CI 2.0–6.3) increased risk of prostate cancer, and when assessed by gene, the relative risk was greatest for MSH2 carriers (5.8, 95 % CI 2.6–20.9). Prostate cancer was the first or only diagnosed tumor in 37 % of carriers. MMR gene mutation carriers have at least a twofold or greater increased risk of developing MMR-deficient prostate cancer where the risk is highest for MSH2 mutation carriers. MMR IHC screening of prostate cancers will aid in identifying MMR gene mutation carriers.
Balanced $k$-nearest neighbor imputation
Creators: name: Hasler, Caren
name: Tillé, Yves
Publisher: name: arXiv
Year: 2015
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In order to overcome the problem of item nonresponse, random imputation methods are often used because they tend to preserve the distribution of the imputed variable. Among the random imputation methods, the random hot-deck has the interesting property of imputing observed values. A new random hot-deck imputation method is proposed. The key innovation of this method is that the selection of donors is viewed as a sampling problem and uses calibration and balanced sampling. This approach makes it possible to select donors such that if the auxiliary variables were imputed, their estimated totals would not change. As a consequence, very accurate and stable totals estimations can be obtained. Moreover, the method is based on a nonparametric procedure. Donors are selected in neighborhoods of recipients. In this way, the missing value of a recipient is replaced with an observed value of a similar unit. This new approach is very flexible and can greatly improve the quality of estimations. Also, this method is unbiased under very different models and is thus resistant to model misspecification. Finally, the new method makes it possible to introduce edit rules while imputing.
A community assessment to inform a multi-level intervention to reduce CVD risk and risk disparities in a rural community
Creators: name: Braxton, Danielle
name: Ammerman, Alice S.
name: McGuirt, Jared T.
name: Keyserling, Thomas C.
name: Huff, Joey V.
name: Pitts, Stephanie B. Jilcott
name: Garcia, Beverly A.
name: Vu, Maihan B.
name: Hengel, Constance E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: In order to complete a formative evaluation to identify community-level assets and barriers to healthy lifestyle choices, we conducted qualitative interviews, community audits, and secondary data analyses. We solicited local leaders’ perspectives regarding ‘win-ability’ of obesity prevention policy options. Participants noted that many resources were available, yet a barrier was high cost. There were more parks per capita in low-income areas, but they were of lower quality. The most winnable obesity prevention policy was incentives for use of food from local farms. Results are being used to inform an intervention to reduce CVD risk in a rural eastern North Carolina.
Gewalt im Tierreich
Creators: name: Wink, Michael
Publisher: name: Heidelberger Jahrbücher Online
Year: 2023

description: Gewalt ist im Tierreich weit verbreitet und tritt in der Auseinandersetzung zwischen unterschiedlichen Arten, vor allem aber intraspezifisch, also innerhalb derselben Art auf. Die Knappheit von Ressourcen (Nahrung, Reviere, Paarungspartner) ist häufig ein Auslöser von Gewalt. Bei Ressourcenmangel setzt häufig ein Wettbewerb ein, der sich in ritualisierten Kämpfen, aber auch in Vernichtungskämpfen äußert. Gewalt manifestiert sich auch im Kindesmord (Infantizid) und im Geschwistermord (Siblizid), die unter besonderen Umständen bei einigen Tierarten regelmäßig auftreten. Auch eine erzwungene Paarung (Vergewaltigung) ist im Tierreich nicht unbekannt. Gewalt ist ein Merkmal, dass durch die Natürliche Selektion ausgelesen wurde, und weil es offenbar vorteilhaft für das Überleben ist, wurde es bis heute bei vielen Tierarten beibehalten. Wir Menschen gehören zu den Primaten, unter denen es viele gewalttätige und aggressive Arten gibt. Wir teilen uns einen gemeinsamen Vorfahren mit Gorillas und Schimpansen, die als besonders gewaltig gelten. Es ist daher anzunehmen, dass Gewalt zum evolutionären Erbe bei uns Menschen zählt. Untersuchungen zeigen, dass Mord und Totschlag mit der Sesshaftwerdung und Zivilisierung vor rund 10.000 Jahren deutlich zurückgegangen sind. Demnach ist der moderne Mensch verglichen zu seinen Vorfahren eine ausgesprochen friedfertige Art, auch wenn die vielen Meldungen von Gewalt in den Medien uns das Gegenteil suggerieren. Es wird postuliert, dass beim Menschen eine Art Selbstdomestikation zu größerer Friedfertigkeit erfolgte: Es waren vermutlich die Frauen, die über viele Generationen hinweg durch Damenwahl Männer als Väter für ihren Nachwuchs selektierten, die weniger gewalttätig, dafür aber friedfertig, hilfsbereit und kooperativ waren.
description: Heidelberger Jahrbücher Online, Bd. 8 (2023): Krieg, Konflikt, Solidarität