cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Роль пищевого разнообразия рациона в формировании синдрома избыточного бактериального роста в тонкой кишке
Creators: name: Пилипенко Владимир Иванович
name: Исаков Василий Андреевич
name: Власова Алина Владимировна
name: Найденова Майя Александровна
name: Морозов Сергей Владимирович
Publisher: name: Вопросы питания
Year: 2020
Subjects: дыхательный тест с лактулозой
синдром избыточного бактериального роста в кишечнике
фактическое питание
пищевое разнообразие

description: Синдром избыточного бактериального роста в кишечнике (СИБР) – широко распространенное заболевание, характеризующееся существенным снижением качества жизни. Лечение антибиотиками СИБР недостаточно эффективно – частота рецидивов после успешной терапии высока. Одним из наиболее важных факторов изменения микробиома кишки могут являться особенности питания, способствующие формированию СИБР. Цель – сопоставить пищевое разнообразие у пациентов с выявленным синдромом избыточного бактериального роста водород-продуцирующей флоры в тонкой кишке (СИБР-Н2) и без него. Материал и методы. Обследованы 1023 пациента с подозрением на наличие СИБР. У 973 пациентов выполнен водородно-метановый дыхательный тест с лактулозой, по результатам которого выделены группы с избыточным ростом водород-продуцирующей флоры в тонкой кишке (n=522), с избытком метана (n=340) и без признаков СИБР (n=108). У всех участников методом суточного воспроизведения собирали данные о фактическом питании. Для оценки пищевого разнообразия использован метод подсчета уникальных значений (сount base diversity) пищевых продуктов по 11 группам: злаки, мясо и яйца, рыба и нерыбные продукты моря, жировые продукты, молочные продукты, овощи, бобовые и орехи, фрукты и ягоды, кондитерские изделия, напитки, соусы и пряности. Сравнение средних величин числа позиций в каждой изучаемой группе пищевых продуктов использовалось для сопоставления пищевого разнообразия у пациентов с СИБР-Н2 и без него. Результаты и обсуждение. Более низкое пищевое разнообразие было обнаружено у пациентов с СИБР-Н2 в группах молочной продукции (2,70±1,37 против 3,19±1,34, р<0,001), овощей (5,50±2,22 против 6,29±1,90, р<0,001) и фруктов (1,54±1,38 против 1,99±1,69, р=0,018) по сравнению с пациентами без признаков СИБР. Различия по группам злаков, мяса, рыбы, бобовых и орехов, жировых продуктов и сладостей не достигли уровня статистической значимости. Заключение. Впервые установлены статистически значимые отличия пищевого разнообразия рационов у пациентов с СИБР-Н2 в отношении потребления молочной продукции, овощей и фруктов. Полученные данные могут быть использованы для разработки мер диетологического обеспечения терапии СИБР и профилактики его рецидивов.
Ферментативные гидролизаты белков молочной сыворотки и куриного яйца: получение, физико-химическая и иммунохимическая характеристики
Creators: name: Зорин Сергей Николаевич
name: Сидорова Юлия Сергеевна
name: Мазо Владимир Кимович
Publisher: name: Вопросы питания
Year: 2020
Subjects: ферментативный гидролизат
белок молочной сыворотки
белок куриного яйца
панкреатин
алкалаза
антигенность
молекулярно-массовое распределение

description: Снижение проявлений пищевой аллергии при включении специализированных пищевых продуктов (СПП) в питание детей и взрослых, страдающих этим заболеванием, представляет актуальную задачу. Цель работы – получение и характеристика in vitro гидролизатов пищевых белков для оценки возможности их использования в составе СПП со сниженной потенциальной аллергенностью. Материал и методы. В работе использованы концентрат белка молочной сыворотки (КБМС) и белок куриного яйца (БКЯ), ферменты панкреатин и алкалаза. Протеолиз белков проводили в ферментере в течение 3 ч при соотношении фермент : субстрат 1:50 (по сухому веществу), при оптимальных для панкреатина и алкалазы рН и температуре. Ферменты инактивировали при +75 °С и проводили ультрафильтрацию. Растворы концентрировали методом обратного осмоса и лиофильно высушивали. Методом эксклюзионной жидкостной хроматографии высокого давления оценивали молекулярно-массовое распределение пептидных фракций. Остаточную антигенность определяли методом непрямого твердофазного иммуноферментного анализа и выражали как кратность снижения антигенности относительно исходного белка. Результаты и обсуждение. При протеолизе панкреатином КБМС получен гидролизат с кратностью снижения антигенности 2,3×103 относительно исходного КБМС. Снижение антигенности в 4,7×104 раз было достигнуто при протеолизе КБМС алкалазой. Сочетание ферментолиза КБМС панкреатином или алкалазой с последующей ультрафильтрацией позволило снизить содержание высокомолекулярных пептидов с массой >8,7 кДа. Кратность снижения антигенности по отношению к исходному белку составила при этом соответственно 1,64×105 и 1,90×105. При повторной ультрафильтрации кратность снижения антигенности полученных гидролизатов КБМС с использованием алкалазы или панкреатина была соответственно >1,0×106 и >5,0×105. Кратность снижения антигенности гидролизата БКЯ, полученного протеолизом алкалазой и ультрафильтрацией, по сравнению с исходным БКЯ составила 9,9×104, а при повторной ультрафильтрации – >5,0×105. Заключение. Значительное уменьшение содержания высокомолекулярных пептидов и снижение антигенности пептидных смесей на основе КБМС и БКЯ до значений, позволяющих использовать их в составе гипоаллергенных продуктов, достигается при сочетании протеолиза и двукратной ультрафильтрации через мембрану УФ10.
Carbon nanopowder acts as a Trojan-horse for benzo(α)pyrene in Danio rerio embryos
Creators: name: A. Binelli
name: L. Del Giacco
name: N. Santo
name: L. Bini
name: S. Magni
name: M. Parolini
name: L. Madaschi
name: A. Ghilardi
name: D. Maggioni
name: M. Ascagni
name: A. Armini
name: L. Prosperi
name: C. Landi
name: C. La Porta
name: C. Della Torre
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Computational Biology

description: Carbon-based nanoparticles (CBNs) are largely distributed worldwide due to fossil fuel combustion and their presence in many consumer products. In addition to their proven toxicological effects in several biological models, attention in recent years has focussed on the role played by CBNs as Trojan-horse carriers for adsorbed environmental pollutants. This role has not been conclusively determined to date because CBNs can decrease the bioavailability of contaminants or represent an additional source of intake. Herein, we evaluated the intake, transport and distribution of one of the carbon-based powders, the so-called carbon nanopowder (CNPW), and benzo(α)pyrene, when administered alone and in co-exposure to Danio rerio embryos. Data obtained by means of advanced microscopic techniques illustrated that the “particle-specific” effect induced a modification in the accumulation of benzo(α)pyrene, which is forced to follow the distribution of the physical pollutant instead of its natural bioaccumulation. The combined results from functional proteomics and gene transcription analysis highlighted the different biochemical pathways involved in the action of the two different contaminants administered alone and when bound together. In particular, we observed a clear change in several proteins involved in the homeostatic response to hypoxia only after exposure to the CNPW or co-exposure to the mixture, whereas exposure to benzo(α)pyrene alone mainly modified structural proteins. The entire dataset suggested a Trojan-horse mechanism involved in the biological impacts on Danio rerio embryos especially due to different bioaccumulation pathways and cellular targets.
Guideline for the application of ETV in the sector
Creators: name: Landini, Chiara
name: Arnesano, Francesco
name: Balossino, Elena
Publisher: name: Zenodo
Year: 2020
Subjects: Industrial Symbiosis
Guidelines
ETV sector

description: This report aims to put into practice the inputs provided by the ETV General Verification Protocol, version 1.2 - 27th July 20162 (from now on called “GVP”) and by the Guidance Documents published by the ETV Technical Working Groups.
 The FISSAC project aims to develop and demonstrate a new paradigm built on an innovative industrial symbiosis model towards a zero waste approach in the resource intensive industries of the construction value chain, leading to material closed-loop processes and moving to a circular economy.
 Switching from a linear business model to a circular one can lead to a more sustainable and resource efficient way of supplying products and services to the market. It is therefore crucial to evaluate new production systems from an environmental, social and economic point of view, in order to ensure that investments in circular models are producing tangible results and paving the way to a more sustainable future. The EU-Environmental Technology Verification (ETV) pilot programme has been selected as specific evaluation tool.
title: Improving psychological therapies for older adults by advancing understanding of patient preferences
Creators: name: Cross, Rachel
Publisher: name: University of Glasgow
Year: 2021
Subjects: subject: Patient preferences, older adults, decision-making, psychological therapy, evidence based practice, Mental Health, Telehealth.

description: Background: Evidence-based practice requires using the best research evidence, clinical expertise, and patient characteristics/preferences to inform the provision of appropriate interventions. Although accommodating patient treatment preferences can have a significant positive impact on psychotherapy attendance and outcome, they are often overlooked in clinical decision-making. Aims: To establish the feasibility and acceptability of using self-report questionnaires to elicit older adults’ (OAs) mental health treatment and outcome preferences and determine whether clinicians consider these preferences when selecting treatment. The secondary aim is to establish a preliminary understanding of participants’ responses on the questionnaires. Methods: Two questionnaires were adapted from previous research for this study. Patients were recruited from NHS Lanarkshire Psychological Therapies for Older People service and asked to complete a questionnaire about their preferences for psychological therapy. Clinicians who deliver psychological therapies to OAs were recruited and asked to complete a questionnaire about their decision-making. Participants also rated questionnaire acceptability. Results: 18 patients and 27 clinicians were recruited. Patients expressed preferences for therapy delivered in-person. Their most preferred therapy task was ‘learn ways to be less critical of me’ and outcome was ‘feel more confident’. Clinicians rated their clinical experience as the most influential factor in their decision-making about treatment. They also identified patient insight and previous experience of therapy as the factors with the most influence on whether they consider patient preferences in decision-making, and reported that COVID-19 makes accommodating patient preferences more difficult. Conclusions: questionnaires are a feasible and acceptable method of eliciting OAs’ treatment and outcome preferences and gathering data about clinicians’ decision-making.
A Syzygy Basis for the Centro-Affine Covariants of the Planar Cubic Differential System
Creators: name: HEZZAM, Anis
name: Dahira Dali
Publisher: name: figshare
Year: 2019
Subjects: subject: 10109 Ordinary Differential Equations, Difference Equations and Dynamical Systems
subject: FOS: Mathematics

description: We find a basis for the syzygies between the centro-affine covariants and invariants of planar cubic differential systems. 
title: Tricksters, witches, and warriors: a feminist experiment in rewriting a patriarchal narrative in children’s fantasy literature
Creators: name: Dulemba, Elizabeth O.
Publisher: name: Unversity of Glasgow
Year: 2021
Subjects: subject: tricksters, witches, warriors, children’s literature, fantasy, patriarchy, feminism, feminist studies, writing experiment, mythology, archetypes, goddesses, folktales, fairy tales, The Three Golden Hairs.

description: In this thesis, I identify and analyze mechanisms of patriarchal bias in children’s fantasy literature primarily through the lens of under-represented female tricksters, examining existing literature to reveal ideologies and semiotics that reinforce patriarchal normativity according to limited archetypal representation. Through this study, three insights became clear. First, there are few identified female tricksters in various world mythologies; however, when applying trickster characteristics to mythological archetypes, it becomes evident that there are plenty of female tricksters who are identified by another label: “witch.” I examine the impact this negative stereotype plays on feminine representation of otherwise beloved tricksters, especially within children’s literature. Second, I describe ongoing efforts to unweave patriarchal biases in so-called feminist texts via the trickster archetype, pointing out a common overcorrection through the use of women warriors— women who are stronger and more powerful than men within their patriarchal environments, who create unrealistic expectations for female agency. Third, I point out that by placing women warriors within hegemonic systems, these stories reinforce patriarchal normativity rather than mitigate the suppositions of male superiority, as intended. Therefore, this paper aims to bring new perspective to the negative tropes we employ in our writings for children’s fantasy and suggest the use of more appropriately labeled and embodied female tricksters to help unweave embedded patriarchal biases. I also conduct an experiment to employ my theories by example in the craft application portion of my study—a feminist fantasy novel called Two Lies and a Truth.
Report on the contribution to the standardisation system regarding FISSAC technologies
Creators: name: Martínez, Raquel
Publisher: name: Zenodo
Year: 2020
Subjects: Industrial Symbiosis
Standardisation

description: The Spanish Association for Standardization (UNE), as a European Standardization Body, is a partner in the FISSAC project to provide support regarding the standardization tasks included in the project. This Report on the contribution to the standardization System regarding FISSAC technologies, consists of two different parts: an approximation and analysis of the relevant technical committees, published standards and works under development dealing with the secondary raw materials and products related to FISSAC project. This first part should provide FISSAC members basic information to help decide further steps in the standardization process of the project results. the contribution to standardization, including strategy to follow, envisaged actions or taken and proposals to be made to promote and facilitate the inclusion of project results in standards as a way to disseminate project results within market stakeholders and industry concerned. The strategy for the communication with the corresponding TCs will be elaborated considering which of them can be the most relevant, to what extent the relationship should be established and an initial planning of activities. All these contribution activities will evolve as the project progresses and project results are obtained. This deliverable contains the fields considered of interest related to FISSAC project, that can be useful and relevant for the project activities. Furthermore, it can help to identify standardization gaps that will need to be addressed.
Phytochemical study of Bituminaria basaltica aerial parts, an Italian endemism
Creators: name: R. V. Bandeira Reidel
name: S. Giovanelli
name: A. Pipitone
name: P. Minissale
name: L. Pistelli
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The first phytochemical investigation of the aerial parts of Bituminaria basaltica, an endemic species from the Aeolian Islands, led to the isolation and identification of eight compounds including plicatin B (3), two furanocoumarins: angelicin (1), psoralen (2), three pterocarpans: erybraedin C (4), 3,9-dihydroxy-4-isoprenyl-pterocarpan (5), bitucarpin A (8) and two flavonoid glycosides: isoorientin (6), daidzin (7). Their structures were elucidated by spectroscospic techniques and compared with data reported in the literature. Sesquiterpenes characterised the essential oil composition of the title plant where β-caryophyllene and germacrene D were the main constituents.
Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy
Creators: name: Chen, Lei-Lei
name: Wang, Yong-Bo
name: Song, Ju-Xian
name: Deng, Wan-Kun
name: Lu, Jia-Hong
name: Ma, Li-Li
name: Yang, Chuan-Bin
name: Li, Min
name: Xue, Yu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology

description: Recent studies have demonstrated that dysregulation of macroautophagy/autophagy may play a central role in the pathogenesis of neurodegenerative disorders, and the induction of autophagy protects against the toxic insults of aggregate-prone proteins by enhancing their clearance. Thus, autophagy has become a promising therapeutic target against neurodegenerative diseases. In this study, quantitative phosphoproteomic profiling together with a computational analysis was performed to delineate the phosphorylation signalling networks regulated by 2 natural neuroprotective autophagy enhancers, corynoxine (Cory) and corynoxine B (Cory B). To identify key regulators, namely, protein kinases, we developed a novel network-based algorithm of in silico Kinome Activity Profiling (iKAP) to computationally infer potentially important protein kinases from phosphorylation networks. Using this algorithm, we observed that Cory or Cory B potentially regulated several kinases. We predicted and validated that Cory but not Cory B downregulated a well-documented autophagy kinase, RPS6KB1/p70S6K (ribosomal protein S6 kinase, polypeptide 1). We also discovered 2 kinases, MAP2K2/MEK2 (mitogen-activated protein kinase kinase 2) and PLK1 (polo-like kinase 1), to be potentially upregulated by Cory, whereas the siRNA-mediated knockdown of Map2k2 and Plk1 significantly inhibited Cory-induced autophagy. Furthermore, Cory promoted the clearance of Alzheimer disease-associated APP (amyloid beta [A4] precursor protein) and Parkinson disease-associated SNCA/α-synuclein (synuclein, alpha) by enhancing autophagy, and these effects were dramatically diminished by the inhibition of the kinase activities of MAP2K2 and PLK1. Taken together, our study not only developed a powerful method for the identification of important regulators from the phosphoproteomic data but also identified the important role of MAP2K2 and PLK1 in neuronal autophagy.
Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis
Creators: name: Du, Ailian
name: Huang, Shiqian
name: Zhao, Xiaonan
name: Feng, Kuan
name: Zhang, Shuangyan
name: Huang, Jiefang
name: Miao, Xiang
name: Baggi, Fulvio
name: Ostrom, Rennolds S.
name: Zhang, Yanyun
name: Chen, Xiangjun
name: Xu, Congfeng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against postsynaptic CHRN/AChR (cholinergic receptor nicotinic) in the endplate of skeletal muscle. Our previous studies have identified CA3 (carbonic anhydrase 3) as a specific protein insufficient in skeletal muscle from myasthenia gravis patients. In this study, we investigated the underlying mechanism of how CA3 insufficiency might contribute to myasthenia gravis. Using an experimental autoimmune myasthenia gravis animal model and the skeletal muscle cell C2C12, we find that inhibition of CAR3 (the mouse homolog of CA3) promotes CHRN internalization via a lipid raft-mediated pathway, leading to accelerated degradation of postsynaptic CHRN. Activation of CAR3 reduces CHRN degradation by suppressing receptor endocytosis. CAR3 exerts this effect by suppressing chaperone-assisted selective autophagy via interaction with BAG3 (BCL2-associated athanogene 3) and by dampening endoplasmic reticulum stress. Collectively, our study illustrates that skeletal muscle cell CAR3 is critical for CHRN homeostasis in the neuromuscular junction, and its deficiency leads to accelerated degradation of CHRN and development of myasthenia gravis, potentially revealing a novel therapeutic approach for this disorder.
Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis
Creators: name: Du, Ailian
name: Huang, Shiqian
name: Zhao, Xiaonan
name: Feng, Kuan
name: Zhang, Shuangyan
name: Huang, Jiefang
name: Miao, Xiang
name: Baggi, Fulvio
name: Ostrom, Rennolds S
name: Zhang, Yanyun
name: Chen, Xiangjun
name: Xu, Congfeng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against postsynaptic CHRN/AChR (cholinergic receptor nicotinic) in the endplate of skeletal muscle. Our previous studies have identified CA3 (carbonic anhydrase 3) as a specific protein insufficient in skeletal muscle from myasthenia gravis patients. In this study, we investigated the underlying mechanism of how CA3 insufficiency might contribute to myasthenia gravis. Using an experimental autoimmune myasthenia gravis animal model and the skeletal muscle cell C2C12, we find that inhibition of CAR3 (the mouse homolog of CA3) promotes CHRN internalization via a lipid raft-mediated pathway, leading to accelerated degradation of postsynaptic CHRN. Activation of CAR3 reduces CHRN degradation by suppressing receptor endocytosis. CAR3 exerts this effect by suppressing chaperone-assisted selective autophagy via interaction with BAG3 (BCL2-associated athanogene 3) and by dampening endoplasmic reticulum stress. Collectively, our study illustrates that skeletal muscle cell CAR3 is critical for CHRN homeostasis in the neuromuscular junction, and its deficiency leads to accelerated degradation of CHRN and development of myasthenia gravis, potentially revealing a novel therapeutic approach for this disorder.
title: Are we doing enough? US foreign policy and the Soviet nationalities, 1977-1984
Creators: name: Campbell, Christopher
Publisher: name: Unversity of Glasgow
Year: 2021

description: Between 1977 and 1984, a group of policymakers inside the United States government attempted to harness the growing unrest among the Soviet Union’s ethnic nationalities, with the objective of undermining their geopolitical rival and serving America’s Cold War interests. These officials were motivated by long-standing beliefs about the nature of the Soviet system and the latent power of nationalism as a crucial vulnerability within the USSR. As the relative stability of the détente era passed, a more confrontational relationship emerged between the United States and the USSR. The growth of the global human rights movement and deep structural changes within the international system during the 1970s had opened up new opportunities for American policymakers to attack the internal legitimacy of the Soviet Union. During the Carter administration, and with the blessing of the president, national security adviser Zbigniew Brzezinski and a small cadre of hard-line officials began to focus on the internal nature of the Soviet regime and the domestic drivers of Soviet foreign policy. Through increased research and regular seminars, these officials hoped to improve awareness and knowledge of Soviet nationality issues inside the US government and explore ways to reach the ethnic groups inside the USSR. Radio broadcasting and covert book publication programs were a central part of this strategy, although these policies were never fully accepted as a central part of the administration’s Soviet strategy. In 1981, the incoming Reagan administration contained many individuals, such as Soviet expert Richard Pipes, who were highly sympathetic to these ideas. Reagan officials were eager to explore ways of assaulting the internal cohesion of the Soviet Union as an official objective of US foreign policy, in order to promote greater democratisation and pluralism within the USSR. As such, serious attempts were made to craft concrete policies which would exploit ethnic tensions inside the Soviet Union, before these concepts finally fell from favour in 1984. This thesis explores these themes, offering an in-depth study of the Carter and Reagan administrations’ efforts to exploit the weaknesses of the USSR by manipulating the growing ethnic resentments within the Soviet system. These policies were driven by hard-line individuals in both administrations, figures who held long-standing beliefs that the US government should be doing more to undermine the USSR by embracing policies designed to stir up the Soviet nationalities.
The promise and perils of LLMs for AI driven ontology curation (DRKB talk)
Creators: name: Mungall, Chris
Publisher: name: Zenodo
Year: 2024

description: Presentation from Panel on AI and Biocuration, at NIH DRKB (Data Repositories and Knowledge Bases) meeting Marc 2024Ontologies are fundamental components of informatics infrastructure in domains such as biomedical, environmental, and food sciences, representing consensus knowledge in an accurate and computable form. However, their construction and maintenance demand substantial resources, necessitating substantial collaborative efforts of domain experts, curators, and ontology experts.

 

We present Dynamic Retrieval Augmented Generation of Ontologies using AI (DRAGON-AI), an ontology generation method employing Large Language Models (LLMs) and Retrieval Augmented Generation (RAG). This method can generate textual and logical ontology components, drawing from existing knowledge in multiple ontologies, as well as unstructured textual sources.

 

We assessed DRAGON-AI across ten diverse ontologies, making use of extensive manual evaluation of results. We demonstrate high precision for relationship generation, close to but lower than precision from logic-based reasoning. We also demonstrate definition generation comparable with but lower than human-generated definitions. Notably, expert evaluators were better able to discern subtle flaws in AI-generated definitions. We also demonstrated the ability of DRAGON-AI to incorporate natural language instructions in the form of GitHub issues. 

 

These findings suggest DRAGON-AI's potential to substantially aid the manual ontology construction process. However, our results also underscore the importance of having expert curators and ontology editors drive the ontology generation process.
Redback: A Bayesian inference software package for electromagnetic transients
Creators: name: Sarin, Nikhil
name: Hübner, Moritz
name: Omand, Conor M. B.
name: Setzer, Christian N.
name: Schulze, Steve
name: Adhikari, Naresh
name: Sagués-Carracedo, Ana
name: Galaudage, Shanika
name: Wallace, Wendy F.
name: Lamb, Gavin P.
name: Lin, En-Tzu
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Fulfilling the rich promise of rapid advances in time-domain astronomy is only possible through confronting our observations with physical models and extracting the parameters that best describe what we see. Here, we introduce {\sc Redback}; a Bayesian inference software package for electromagnetic transients. {\sc Redback} provides an object-orientated {\sc python} interface to over 12 different samplers and over 100 different models for kilonovae, supernovae, gamma-ray burst afterglows, tidal disruption events, engine-driven transients among other explosive transients. The models range in complexity from simple analytical and semi-analytical models to surrogates built upon numerical simulations accelerated via machine learning. {\sc Redback} also provides a simple interface for downloading and processing data from various catalogs such as \textit{Swift} and Fink. The software can also serve as an engine to simulate transients for telescopes such as the Zwicky Transient Facility and Vera Rubin with realistic cadences, limiting magnitudes, and sky-coverage or a hypothetical user-constructed survey or a generic transient for target-of-opportunity observations with different telescopes. As a demonstration of its capabilities, we show how {\sc Redback} can be used to jointly fit the spectrum and photometry of a kilonova, enabling a more powerful, holistic probe into the properties of a transient. We also showcase general examples of how {\sc Redback} can be used as a tool to simulate transients for realistic surveys, fit models to real, simulated, or private data, multi-messenger inference with gravitational waves, and serve as an end-to-end software toolkit for parameter estimation and interpreting the nature of electromagnetic transients.
description: Published in MNRAS. 25 pages 11 figures. Redback is available on GitHub at https://github.com/nikhil-sarin/redback
A Syzygy Basis for the Centro-Affine Covariants of the Planar Cubic Differential System
Creators: name: HEZZAM, Anis
name: Dahira Dali
Publisher: name: figshare
Year: 2017
Subjects: subject: 10109 Ordinary Differential Equations, Difference Equations and Dynamical Systems
subject: FOS: Mathematics

description: We find a basis for the syzygies between the centro-affine covariants and invariants of planar cubic differential systems. 
title: Think of what you’re saying: mapping the evolution and impact of the Beatles’ lyrical approaches to gender in 1965-1966
Creators: name: Gallaher, Lisette F.
Publisher: name: University of Glasgow
Year: 2021

description: This dissertation explores the evolution of the Beatles’ lyrics focusing on gender. Placing their work in social and historical context, this thesis examines the shifting relationship between the Beatles and their largely female fanbase by focusing on two key questions: 1) how did the Beatles’ lyrical approaches to gender change over time, and what insight does this give historians into how the Beatles shaped history, specifically in connection to their involvement with the counterculture, and 2) given the Beatles’ quasi-religious, young female fanbase, how did the band’s evolution of portrayal and representation of gender impact their fans? In addressing these questions, I employ historical, musicological and gender theory lenses to the Beatles music, fanbase, and historical context in order to provide the interdisciplinary approach this cultural study requires.
Sources, distribution, and decomposition stages of sedimentary organic matter in estuaries and its adjacent areas
Creators: name: Yuan, Hong-Wei
name: Loh, Pei Sun
name: Lin, Shi-Yuan
name: Hu, Xin-Ying
name: Qian, Jing
name: Chen, Jian-Fang
name: Ye, Ying
name: Lou, Zhang-Hua
name: Jin, Ai-Min
name: Chen, Xue-Gang
name: Jiang, Zong-Pei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Lignin-derived phenols, C/N ratios and ratios of refractory to total organic matter were used to study the sources, distribution, and diagenesis of sedimentary organic matter along estuary, river bank, and salt marsh systems. The Changjiang Estuary showed a higher signal of terrestrial organic matter at the river mouth which decreased farther offshore. The locations along the Qiantang River were affected by their adjacent surroundings, and the Andong salt marsh showed higher terrestrial organic matter signal at the upper marsh compared to the lower marsh. All studied areas showed slight increases in organic matter decomposition farther downstream and towards the sea. Study of these three different systems will improve our understanding on their ecotoxicological impact. The Changjiang Estuary had higher pollutant levels near the river mouth, which decreased farther offshore due to dilution. The midstream Qiantang River was most likely affected by pollution from their adjacent surroundings. Pollutants were likely to be accumulated in the Andong salt marsh due to the presence of marsh plants and small-sized particles. Organic pollutants were likely to be decomposed during transport along the systems. The ability of the sediments to release inorganic pollutants was determined by whether these systems were oxic or anoxic.
LC-ESI-MS/MS profiling of phenolics in the leaves of Eleutherococcus senticosus cultivated in the West Europe and anti-hyaluronidase and anti-acetylcholinestarase activities
Creators: name: Rafał Kuźniewski
name: Załuski, Daniel
name: Olech, Marta
name: Banaszczak, Piotr
name: Nowak, Renata
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Neither secondary metabolites of the spring leaves nor the autumn leaves of Eleutherococcus senticosus species cultivated in Poland, or the bioactivity are known. The richest in polyphenols was the autumn leaves (171.1 mg/g DE), while in flavonoids the spring leaves (107.9 mg/g DE). Using LC-ESI-MS/MS, protocatechuic acid has been identified as the most abundant compound in the spring and autumn leaves (200 and 70 μg/g DE, respectively). Amongst flavonoids, naringenin 7-O-glucoside occurred in the largest amount (20 and 10 mg/g DE in the spring and autumn leaves, respectively). The autumn leaves inhibited Hyal the strongest (74.3%), comparing to the spring leaves (33%). A weak inhibition was found towards AChE (0.64 and 5.8% for the autumn and spring leaves, respectively). To our best knowledge, no information was available on the phytochemical composition and activity of the leaves of E. senticosus cultivated in Poland.
Entretien d'Arzaq Abu Id auprès de Udh Ibrahim Mharram à propos du café Raouché de Zarqa
Creators: name: Mharram, Udh Ibrahim
name: Arzaq Abu Id (Enquêtrice)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/FileId-3139
description: Coverage: Zarqa, Jordanie
Engineering the bacterial endophyte Burkholderia pyrrocinia JK-SH007 for the control of lepidoptera larvae by introducing the cry218 genes of Bacillus thuringiensis
Creators: name: Li, Yang
name: Wu, Choufei
name: Xing, Zhong
name: Gao, Bingli
name: Zhang, Liqin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: To expand the usage of endophytes in agriculture and in forestry, the insecticidal gene cry218 of Bacillus thuringiensis was introduced into a poplar bacterial endophyte Burkholderia pyrrocinia JK-SH007. The cry218 gene was cloned by polymerase chain reaction (PCR) and was inserted into a PHKT2 expression vector that was introduced into the bacterial endophyte JK-SH007. By using sodium dodecyl sulphate polyacryl amide gel electrophoresis (SDS-PAGE) and western blotting, we confirmed that the engineered bacterial endophyte was successfully constructed, and it harboured insecticidal function after the bioassay in planta. The toxicity of the expressed insecticidal protein was analysed on second instar silkworm. The regression equation showed that the median lethal concentration (LC50) of the insecticidal protein was 0.77 (0.57–1.04) g/L at 72 h. The insecticidal bacteria genetically modified in this study have laid the foundation for further exploitation of biocontrol bacteria.
The Evolution of EU Differentiated Integration between Crises and Dilemmas
Creators: name: Brunazzo, Marco
Publisher: name: Zenodo
Year: 2019
Subjects: European Union
Differentiated integration
European integration

description: This paper analyses the debate about differentiated integration (DI) from the beginning of the European Union integration process to the 2016 referendum on the withdrawal of the United Kingdom from the EU. This debate can be divided in three different periods, according to the main dilemmas that policymakers tried to address: (i) a political dilemma about the final “destination” of the EU integration project between the 1950s and the 1980s; (ii) a legal dilemma about the mechanism to adopt to promote DI in the 1980s and the 1990s; and (iii) an institutional dilemma about the growing complexity of EU institutions, begun in the 2000s and encapsulated in the Lisbon Treaty (2007). As the paper shows, every period of debate coincided with a specific type of crisis – respectively, a “crisis of design”, a crisis of (foreseen) enlargement and a crisis of economic adaptation.
title: A comparison of decorative features in the Ælfrician textual tradition
Creators: name: Rae, Emily M.
Publisher: name: University of Glasgow
Year: 2021

description: This thesis investigates the enlarged and decorated initials in manuscripts containing texts from Ælfric’s First Series of Catholic Homilies, specifically those that begin new texts. I demonstrate that such aspects of mise-en-page are transferred from manuscript to manuscript with the texts they accompany; furthermore, this transference accompanies known routes of textual dissemination. This thesis is divided broadly into four sections. Following the first, in which I provide research contextualisation along with a discussion of relevant terminology, I next focus on groups of manuscripts identified as closely related based on their textual content. I here note several points of previously unnoticed exceptional visual similarity between these textually-linked manuscripts, most notably between several texts occurring in MS Cott Faust A. ix and MS CCCC 302. In the third section, I focus on texts that are particularly frequently copied: Ælfric’s First Series homilies for Pentecost (ÆCHom I, 22), the Lord’s Prayer (ÆCHom I, 19), and All Saints’ Day (ÆCHom I, 36). I compile the appearance of text-beginning initials across all surviving instances of the texts; ÆCHom I, 36 especially shows evidence of letter-form transference across multiple manuscripts, namely MS CCCC 303; MSS Bod 340/342; MS Cott Vesp D. XIV; and MSS Hatton 113 and 114 and MS Junius 121. In the final section, I include additional case studies that argue that the above similarities are significant, and not a result of scribal standards or specific house styles. I begin with an investigation into the decoration of other vernacular manuscripts from a similar time and place of origin: CCCC 201, CCCC 322, MS Cott Tib B. I, and MS Cott Vesp D. XXI. I also include manuscripts, and one comparing two homilies in two related volumes.
Blood pressure effects of adiposity in non-overweight children aged 6–17 years
Creators: name: Tian, Changwei
name: Xu, Shuang
name: Wang, Hua
name: Wang, Wenming
name: Shen, Hui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Background: Obesity is a well-established risk factor of elevated blood pressure; however, the relationships between normal weight status and the risk of hypertension and pre-hypertension are not clear. Aim: The aim of this study is to describe the blood pressure effects of adiposity in non-overweight children. Methods and results: In total, 588 097 non-overweight children aged 6–17 years were included from the National Surveys on Students’ Constitution and Health. A non-linear relationship was found between age- and gender-standardised body mass index (BMI) z-score and pre-hypertension and hypertension, respectively. The odds ratios and 95% confidence intervals [ORs (95% CIs)] of pre-hypertension were 0.61 (0.59–0.63), 0.67 (0.65–0.68), 0.83 (0.83–0.84), 1.00 (reference), 1.13 (1.12–1.14), 1.18 (1.16–1.20) and 1.20 (1.18–1.22) for BMI z-scores of −1.2, −1.0, −0.5, 0 (reference), 0.5, 0.7 and 0.8, respectively. The ORs (95% CIs) of hypertension were 0.56 (0.54–0.58), 0.62 (0.61–0.64), 0.81 (0.80–0.82), 1.00 (reference), 1.17 (1.16–1.18), 1.23 (1.22–1.5) and 1.27 (1.24–1.29) for BMI z-scores of −1.2, −1.0, −0.5, 0 (reference), 0.5, 0.7 and 0.8, respectively. The above-mentioned associations were consistent in sub-group analysis by age, gender and height. Conclusions: Non-linear relationships of BMI z-scores with pre-hypertension and hypertension were found in non-overweight children. Interventions to control blood pressure are also important in non-overweight children.
Working memory and domain in DLD (Larson & Ellis Weismer, 2022)
Creators: name: Larson, Caroline
name: Ellis Weismer, Susan
Publisher: name: ASHA journals
Year: 2022
Subjects: Child language acquisition
Speech pathology
Memory and attention

description: Purpose: This study examined working memory in children with developmental language disorder (DLD). The overarching goal of this work was to integrate three primary processing-based hypotheses of DLD, (a) limited verbal working memory, (b) slowed processing speed, and (c) inefficient inhibition of interference, by using the serial-order-in-a-box–complex span (SOB-CS) computational model as our theoretical framework. We also examined the role of domain in working memory performance by varying the domain of interference and recall (i.e., verbal vs. nonverbal) task demands.Method: Participants were 55 school-age children, 21 children with DLD and 34 age-matched typically developing (TD) peers (9–13 years old).Results: Findings indicated that verbal and nonverbal working memory performance was poorer in the DLD than TD group. There was a modest benefit of dispersing interference and recall task demands across domains relative to task demands being within one domain, yet verbal interference affected performance to a greater degree than nonverbal interference in the DLD group.Conclusions: Overall findings supported a role for each of the processing-based hypotheses of DLD, albeit an incomplete role. In contrast, the SOB-CS model accounted for interrelationships among these processing-based factors and provided an explanation across patterns of findings. Thus, the SOB-CS model represents a useful step forward in explaining processing in children with DLD.
Supplemental Material S1. Additional methods.
Supplemental Material S2. Multiple imputation mixed-effects model results.
Larson, C., & Ellis Weismer, S. (2022). Working memory performance in children with developmental language disorder: The role of domain. Journal of Speech, Language, and Hearing Research. Advance online publication. https://doi.org/10.1044/2022_JSLHR-21-00420
title: 01_1647
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/