cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus
Creators: name: Cone, Richard
name: Ensign, Laura M.
name: Moench, Thomas
name: Schroeder, Holly
name: Chattopadhyay, Sumon
name: Roffler, Steve R.
name: Wang, Ying-Ying
name: Hoang, Thuy
name: Nunn, Kenetta L.
name: McCallen, Justin
name: Henry, Christine E.
name: Hoen, Timothy
name: Lai, Samuel K.
name: Yang, Qi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Antibodies that specifically bind polyethylene glycol (PEG) can lead to rapid elimination of PEGylated therapeutics from the systemic circulation. We have recently shown that virus-binding IgG can immobilize viruses in mucus via multiple low-affinity crosslinks between IgG and mucins. However, it remains unclear whether anti-PEG antibodies in mucus may also alter the penetration and consequently biodistribution of PEGylated nanoparticles delivered to mucosal surfaces. We found that both anti-PEG IgG and IgM can readily bind nanoparticles that were densely coated with PEG polymer to minimize adhesive interactions with mucus constituents. Addition of anti-PEG IgG and IgM into mouse cervicovaginal mucus resulted in extensive trapping of mucus-penetrating PEGylated nanoparticles, with the fraction of mobile particles reduced from over 95% to only 34% and 7% with anti-PEG IgG and IgM, respectively. Surprisingly, we did not observe significant agglutination induced by either antibody, suggesting that particle immobilization is caused by adhesive crosslinks between mucin fibers and IgG or IgM bound to individual nanoparticles. Importantly, addition of corresponding control antibodies did not slow the PEGylated nanoparticles, confirming anti-PEG antibodies specifically bound to and trapped the PEGylated nanoparticles. Finally, we showed that trapped PEGylated nanoparticles remained largely in the luminal mucus layer of the mouse vagina even when delivered in hypotonic formulations that caused untrapped particles to be drawn by the flow of water (advection) through mucus all the way to the epithelial surface. These results underscore the potential importance of elucidating mucosal anti-PEG immune responses for PEGylated therapeutics and biomaterials applied to mucosal surfaces.
Neutrinos from SN 1987a. A Puzzle Revisited
Creators: name: Schatz, Gerd
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The smallest of the four detectors which claim to have observed neutrinos from SN 1987a registered the events more than 4 h earlier than the other three ones. This claim is not usually accepted because it is difficult to understand that the other (and larger) detectors did not register any events at the same time. It is shown that microlensing of the neutrinos by a star in-between the supernova (SN) and Earth can enhance the neutrino intensity at the position of one detector by more than an order of magnitude with respect to the other detectors. Such a configuration is improbable but not impossible. Essential for this enhancement is the small source diameter, of order 100 km. So if two bursts of neutrinos were emitted by SN 1987a at a separation of about 4 h it could be explained easily that the smallest detector observed the first burst while the other ones missed it and vice versa.
description: Paper presented at the 24th European Cosmic Ray Symposium Kiel 2014
Impacts of the European Rabbit (Oryctolagus cuniculus) on Eucalyptus regeneration in Box-Gum Grassy Woodland
Creators: name: Brickhill, Hannah Cassinia
Publisher: name: The Australian National University
Year: 2010

description: Insufficient natural regeneration in an issue affecting modified landscapes around the world. Loss of tree cover due to a lack of regeneration has a detrimental effect on both biodiversity and agricultural productivity in these landscapes. Insufficient Eucalyptus regeneration is an established problem in Box-Gum Grassy Woodland, a threatened ecological community in south-eastern Australia. The European Rabbit (Oryctolagus cuniculus) is known to prevent recruitment of many species of woody perennials across a range of ecosystems. Its distribution overlaps with that of Box-Gum Grassy Woodland. Despite this, there have been very few studies on the effects of grazing by the European Rabbit on Eucalyptus regeneration in this ecological community. I investigated the impact of the European Rabbit on regeneration of Yellow Box (Eucalyptus mellidora) and Blakely's Red Gum (E. blakeyi) in Box-Gum Grassy Woodland in a Canberra nature reserve. One hundred and fifty seedlings of Yellow Box and Blakely's Red Gum were planted across a range of rabbit densities. Fifty of these seedlings were caged, representing zero rabbit density. At the location of each seedling I recorded potential explanatory variables representing three factors that may affect the impact of the European Rabbit on the survival of Eucalyptus seedlings: rabbit density, total availability of food and competition with other herbivores. The survival of planted seedlings was assessed after 6 weeks. I also measured the abundance of naturally occurring Eucalyptus seedlings at 100 sites in a retrospective study to assess longer-term impacts of rabbit grazing. Planted seedlings at zero rabbit density (caged seedlings) had a significantly higher probability of survival than uncaged planted seedlings, although this difference was minor. There was a significant association between rabbit density (as measured by rabbit diggings) and the survival of planted seedlings; however, seedling survival was only negatively associated with rabbit density at sites with a high cover of forbs. Rabbit density was also negatively associated with the abundance of naturally occurring Eucalyptus seedlings. This effect was greatest at sites with high grass cover. A high density of the other major herbivore at the site, the Eastern Kangaroo Grey (Macropus giganteus), did not drive rabbits to consume more seedlings. Although this study did not provide compelling evidence that the European Rabbits impacts Eucalyptus regeneration in Box-Gum Grassy Woodland, it does suggests that the rabbit presents a potential threat and rabbit control should be considered as part of restoration efforts in this ecological community.
Constructing solutions to the Björling problem for isothermic surfaces by structure preserving discretization
Creators: name: Bücking, Ulrike
name: Matthes, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 53A05, 65M12, 65M22

description: In this article, we study an analog of the Björling problem for isothermic surfaces (that are more general than minimal surfaces): given a real analytic curve $γ$ in ${\mathbb R}^3$, and two analytic non-vanishing orthogonal vector fields $v$ and $w$ along $γ$, find an isothermic surface that is tangent to $γ$ and that has $v$ and $w$ as principal directions of curvature. We prove that solutions to that problem can be obtained by constructing a family of discrete isothermic surfaces (in the sense of Bobenko and Pinkall) from data that is sampled along $γ$, and passing to the limit of vanishing mesh size. The proof relies on a rephrasing of the Gauss-Codazzi-system as analytic Cauchy problem and an in-depth-analysis of its discretization which is induced from the geometry of discrete isothermic surfaces. The discrete-to-continuous limit is carried out for the Christoffel and the Darboux transformations as well.
description: 29 pages, some figures
Historic-Habitat Selection and Post-Reintroduction Population Biology of the New Holland Mouse
Creators: name: Abicair, Kristen
Publisher: name: The Australian National University
Year: 2016

description: The historic distribution of the New Holland Mouse, coupled with the ecological shifts associated with Australian colonisation, suggests the species currently resides in refuge habitats. Current habitat models for the New Holland Mouse are based on its extant distribution, describing the species as an early successional post fire habitat specialist of select coastal vegetation. This study describes the first account of habitat selection by the species postreintroduction into an historic environment, and in absence of exotic predation. A novel method for detection of the species was developed and used to reveal habitat preferences that differ from current habitat models, and genetic diversity was also assessed at three stages of the reintroduction using microsatellite analysis. Findings suggest that the means by which the species is able to persist in an historic environment leaves it pre-disposed to exotic predation, more so than in current locations. Loss of genetic diversity and an increased inbreeding coefficient was identified during the captive breeding phase. The current population size is seemingly small with only fourteen individuals identified, and allelic richness has also declined. The introduction of additional founders is suggested to increase population size and insure gene flow. In light of this study, more diverse potential habitat for the species has been identified, subsequently expanding on our knowledge on the fundamental ecology of the species prior to European settlement. Furthermore, this study highlights the potential to incorporate historic habitat in modelling for species recovery programs, and presents a holistic framework for assessing post-reintroduction population biology, to best inform on past methods and future management action.
Fabrication of novel high surface area mushroom gilled fibers and their effects on human adipose derived stem cells under pulsatile fluid flow for tissue engineering applications
Creators: name: Pourdeyhimi, Behnam
name: Loboa, Elizabeth G.
name: Tuin, Stephen A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Abstract The fabrication and characterization of novel high surface area hollow gilled fiber tissue engineering scaffolds via industrially relevant, scalable, repeatable, high speed, and economical nonwoven carding technology is described. Scaffolds were validated as tissue engineering scaffolds using human adipose derived stem cells (hASC) exposed to pulsatile fluid flow (PFF). The effects of fiber morphology on the proliferation and viability of hASC, as well as effects of varied magnitudes of shear stress applied via PFF on the expression of the early osteogenic gene marker runt related transcription factor 2 (RUNX2) were evaluated. Gilled fiber scaffolds led to a significant increase in proliferation of hASC after seven days in static culture, and exhibited fewer dead cells compared to pure PLA round fiber controls. Further, hASC-seeded scaffolds exposed to 3 and 6 dyn/cm resulted in significantly increased mRNA expression of RUNX2 after one hour of PFF in the absence of soluble osteogenic induction factors. This is the first study to describe a method for the fabrication of high surface area gilled fibers and scaffolds. The scalable manufacturing process and potential fabrication across multiple nonwoven and woven platforms makes them promising candidates for a variety of applications that require high surface area fibrous materials. Statement of Significance We report here for the first time the successful fabrication of novel high surface area gilled fiber scaffolds for tissue engineering applications. Gilled fibers led to a significant increase in proliferation of human adipose derived stem cells after one week in culture, and a greater number of viable cells compared to round fiber controls. Further, in the absence of osteogenic induction factors, gilled fibers led to significantly increased mRNA expression of an early marker for osteogenesis after exposure to pulsatile fluid flow. This is the first study to describe gilled fiber fabrication and their potential for tissue engineering applications. The repeatable, industrially scalable, and versatile fabrication process makes them promising candidates for a variety of scaffold-based tissue engineering applications. Graphical abstract
High-Efficiency All-Dielectric Metasurfaces for Ultra-Compact Beam Manipulation in Transmission Mode
Creators: name: Shalaev, Mikhail I.
name: Sun, Jingbo
name: Tsukernik, Alexander
name: Pandey, Apra
name: Nikolskiy, Kirill
name: Litchinitser, Natalia M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Metasurfaces are two-dimensional optical structures enabling complete control of the amplitude, phase, and polarization of light. Unlike plasmonic metasurfaces, planar silicon structures facilitate high transmission, low losses and compatibility with existing semiconductor technologies. Here, we report an experimental demonstration of high-efficiency polarization- sensitive dielectric metasurfaces with full 2pi phase control in transmission mode at telecommunication wavelengths. Such silicon metasurfaces are poised to enable a versatile optical platform the realization of all-optical circuitry on a chip.
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates
Creators: name: Kordower, Jeffrey H.
name: Gray, Steven J.
name: McCown, Thomas
name: Kirik, Deniz
name: Chu, Yaping
name: Marmion, David J.
name: Heindel, Clifford
name: Mandel, Ronald J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather than neurons. Glial cytoplasmic inclusions (GCIs) of α-syn are thought to elicit changes in oligodendrocyte function, such as reduced neurotrophic support and demyelination, leading to neurodegeneration. To date, only a murine model using one of three promoters exist to study this disease. We sought to develop novel rat and nonhuman primate (NHP) models of MSA by overexpressing α-syn in oligodendroglia using a novel oligotrophic adeno-associated virus (AAV) vector, Olig001. To establish tropism, rats received intrastriatal injections of Olig001 expressing GFP. Histological analysis showed widespread expression of GFP throughout the striatum and corpus callosum with >95% of GFP+ cells co-localizing with oligodendroglia and little to no expression in neurons or astrocytes. We next tested the efficacy of this vector in rhesus macaques with intrastriatal injections of Olig001 expressing GFP. As in rats, we observed a large number of GFP+ cells in gray matter and white matter tracts of the striatum and the corpus callosum, with 90-94% of GFP+ cells co-localizing with an oligodendroglial marker. To evaluate the potential of our vector to elicit MSA-like pathology in NHPs, we injected rhesus macaques intrastriatally with Olig001 expressing the α-syn transgene. Histological analysis 3-months after injection demonstrated widespread α-syn expression throughout the striatum as determined by LB509 and phosphorylated serine-129 α-syn immunoreactivity, all of which displayed as tropism similar to that seen with GFP. As in MSA, Olig001-α-syn GCIs in our model were resistant to proteinase K digestion and caused microglial activation. Critically, demyelination was observed in the white matter tracts of the corpus callosum and striatum of Olig001-α-syn but not Olig001-GFP injected animals, similar to the human disease. These data support the concept that this vector can provide novel rodent and nonhuman primate models of MSA.
Measuring Metrics - A forty year longitudinal cross-validation of citations, downloads, and peer review in Astrophysics
Creators: name: Kurtz, Michael J.
name: Henneken, Edwin A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Digital Libraries (cs.DL)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Citation measures, and newer altmetric measures such as downloads are now commonly used to inform personnel decisions. How well do or can these measures measure or predict the past, current of future scholarly performance of an individual? Using data from the Smithsonian/NASA Astrophysics Data System we analyze the publication, citation, download, and distinction histories of a cohort of 922 individuals who received a U.S. PhD in astronomy in the period 1972-1976. By examining the same and different measures at the same and different times for the same individuals we are able to show the capabilities and limitations of each measure. Because the distributions are lognormal measurement uncertainties are multiplicative; we show that in order to state with 95% confidence that one person's citations and/or downloads are significantly higher than another person's, the log difference in the ratio of counts must be at least 0.3 dex, which corresponds to a multiplicative factor of two.
description: Author's version of manuscript accepted for publication in the Journal of the Association for Information Science and Technology (JASIST); 35 pages 16 figures
Double posets and the antipode of QSym
Creators: name: Grinberg, Darij
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05E05, 05E18

description: A quasisymmetric function is assigned to every double poset (that is, every finite set endowed with two partial orders) and any weight function on its ground set. This generalizes well-known objects such as monomial and fundamental quasisymmetric functions, (skew) Schur functions, dual immaculate functions, and quasisymmetric $\left(P, ω\right)$-partition enumerators. We prove a formula for the antipode of this function that holds under certain conditions (which are satisfied when the second order of the double poset is total, but also in some other cases); this restates (in a way that to us seems more natural) a result by Malvenuto and Reutenauer, but our proof is new and self-contained. We generalize it further to an even more comprehensive setting, where a group acts on the double poset by automorphisms.
description: 51 pages. Comments are welcome! Version 3: Accepted for publication; exposition much improved, errors corrected, and Remark 4.9 added
Know your place - Social network analysis in cooperatively breeding white-winged choughs (Corcorax melanorhamphos)
Creators: name: Ying, Lee Shu
Publisher: name: The Australian National University
Year: 2019

description: Cooperative breeding is a specialised type of social system in which individuals work together as a group to raise young. This breeding system entails variable costs and benefits for individuals based on their position in group social structure. Social network analysis has become an important tool for understanding causes and consequences of individual positions in such social structures. In this thesis I used social network analysis to understand the impact of individual attributes and behaviours on the social position of group members of an obligate cooperatively breeding bird, the white-winged chough (Corcorax melanorhamphos). I studied five cooperative groups of choughs in the Canberra area and constructed networks from spatial association data to give values for two group-level and three individual-level social network measures. The two group-level social network measures were the extent of their assortative behaviour based on their traits (assortativity) and social cohesion (density). The three individual-level social network measures were number and strength of direct associations (weighted degree), distance to all other individuals in the group (closeness centrality) and network connectedness (eigenvector centrality). I also identified social clusters. I then compared social networks between two stages of breeding, the nesting and post-fledging stages, to understand the impact of nesting activity on social structure. My results confirmed the validity of using networks derived from spatial associations in choughs to quantify social structure and changes in structure. The networks showed that choughs do not assort by age, likely due to poor foraging skills in immature choughs. Choughs assorted by sex but not by breeding status, possibly reflecting differences in mating strategies. Individual traits that impacted a chough’s direct associations might reflect mating strategies, demographics and resource availability. Group size had a significant impact on social measures, suggesting a need for selectivity in choices of social partners due to fewer opportunities to socialise. I suggest that the maintenance of networks between the two breeding stages was a result of choughs compensating for the cost of time investment on their key relationships from nest sitting. Changes in individual network position between breeding stages correlate to contributions to care of young, providing support for the social prestige hypothesis.
A prospective study of maternal, fetal and neonatal outcomes in the setting of cesarean section in low- and middle-income countries
Creators: name: Koso-Thomas, Marion
name: Goldenberg, Robert L.
name: Saleem, Sarah
name: Tshefu, Antoinette K.
name: Bauserman, Melissa
name: Mcclure, Elizabeth M.
name: Miodovnik, Menachem
name: Belizan, Jose
name: Pasha, Omrana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Abstract Introduction Cesarean section (CS) rates are increasing globally with an unclear effect on pregnancy outcomes. The study objective was to quantify maternal and perinatal morbidity and mortality associated with CS compared with vaginal delivery (VD) both within and across sites in low‐ and middle‐income countries. Material and methods A prospective population‐based study including home and facility births in 337 153 women with a VD and 47 308 women with a CS from 2010 to 2015 was performed in Guatemala, India, Kenya, Pakistan, Zambia and Democratic Republic of Congo. Women were enrolled during pregnancy; delivery and 6‐week follow‐up data were collected. Results Across all sites, CS rates increased from 8.6% to 15.2%, but remained low in African sites. Younger, nulliparous women were more likely to have a CS, as were women with higher education and those delivering an infant weighing 1500–2499 g. Across all sites, maternal and neonatal mortality was higher, and stillbirths were lower, in pregnancies delivered by CS. Antepartum and postpartum complications as well as obstetric interventions and treatments were more common among women who underwent CS. In stratified analyses, all outcomes were worse in women with a CS compared with VD in African compared to non‐African sites. Conclusions CS rates increased across all sites during the study period, but at more pronounced rates in the non‐African sites. CS was associated with reduced postpartum hemorrhage and lower rates of stillbirths in the non‐African sites. In the African sites, CS was associated with an increase in all adverse outcomes. Further studies are necessary to better understand the increase in adverse outcomes with CS in the African sites.
Systematic review and meta-analysis of fire needle therapy in the treatment of gout arthritis
Creators: name: Fan, Yihua
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: Objective: To evaluate the efficacy and safety of fire needle therapy in the treatment of gouty arthritis. Methods:The randomized controlled trials (RCTs) of fireneedle therapy for gout arthritis were searched by computer for PubMed, The Cochrane Library, EMBASE, Web of Science, Chinese National Knowledge Infrastructure( CNKI), Wanfang database, VIP databases and Chinese biomedical literature database(CBM). The retrieval period was from establishment of The database to May 2020.Two researchers independently screened the literature, extracted the data and evaluated the risk of bias included in the study, then Meta analysis was performed using RevMan5.3 software.
Reed bee (Exoneura spp.) pollination efficiency and nesting preferences in a Rubus berry orchard in the Yarra Valley, Australia
Creators: name: Coates, Joshua
Publisher: name: The Australian National University
Year: 2020

description: Agricultural pollination services are largely reliant upon the European honeybee (Apis mellifera), a species which is seeing global declines. Native bees have the potential to act as agricultural pollinators, to diversify and add resilience to current honeybee-reliant pollination services. However, little is currently known about the potential for Australian native bees to act as efficient crop pollinators. My thesis examines the role that the reed bee (Exoneura spp.) and white-banded bee (Lasioglossum (Chilalictus)) spp.) might play in pollinating a Rubus crop, and whether the reed bee in particular will nest in this crop. Single-visit pollination data and nesting preference data were collected in the spring of 2019 at a berry orchard in the Yarra Valley, Victoria, Australia. I found that reed bees and white-banded bees were equally efficient in pollinating blackberries (Rubus fruticosus sp. agg.) as honeybees, and were associated with a three-fold increase in drupelet set compared to the control group. I also found that reed bees will willingly nest within a raspberry (Rubus idaeus) crop in large numbers (mean estimate of 3,320 bees per hectare), and that they show preferences towards narrow and more upright stems when choosing a suitable nest. These findings suggest that reed bees show promise as a Rubus pollinator, and exhibit nesting behaviors that may enable land managers to increase reed bee numbers across their properties. This research helps to provide the basis for the management of this genus and highlights avenues for future research.
Inhomogeneous refinement equations with random affine maps
Creators: name: Kapica, Rafał
name: Morawiec, Janusz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: Given a probability space $(Ω,{\mathcal A},P)$, random variables $L,M\colonΩ\to\mathbb R$ and $g\in L^1(\mathbb R)$ we obtain two characterizations of these $f\in L^1(\mathbb R)$ which are solutions of the inhomogeneous refinement equation with a random affine map of the form $f(x)=\int_Ω|L(ω)|f(L(ω)x-M(ω))P(dω)+g(x)$.
description: the final version will be published in Journal of Difference Equations and Applications
Supplement Number 1
Creators: name: Li, Hanyang
name: Yang, Xulong
name: Zhou, Gaoqian
name: Sun, Jiapeng
name: Chen, Ying
name: Tang, Xianqi
name: Ge, Yang
Publisher: name: AIP Publishing
Year: 2024
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: A detailed account of the
parameterized drive model, including the linear relationship between
the controlled integration factor and the initial parameters, as well as
the bubble's energy.
Vergänglichkeit im 17. Jahrhundert am Beispiel von Epitaphien in der St. Marienkirche zu Berlin
Creators: name: Altmann, Yasmin
Publisher: name: Zenodo
Year: 2023
Subjects: Berliner St. Marienkirche
Vanitas
Vergänglichkeit
Epitaph

description: Das Poster setzt sich mit dem barocken Vergänglichkeitsbegriff am Beispiel der Epitaphien der Berliner Marienkirche auseinander.
description: Posterpräsentation der X-Student Research Group "Berliner Inschriften als Quelle für die historische Registerforschung" (Gohar Schnelle, Dina Serova, finanziert durch die Berlin University Alliance) am 03.04.2023.
Barriers and facilitators to the implementation of social robotics for older adults: A scoping review
Creators: name: Koh, Wei Qi
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: barriers and facilitators
subject: implementation
subject: older adults
subject: social robot

description: This is the registration for our scoping review titled: "Barriers and facilitators to the implementation of social robotics for older adults: A scoping review". There have been no prior registrations.
Examining Question and Answer Sessions at Conferences
Creators: name: Ebersole, Charles
name: Jarvis, Shoshana
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: conferences
subject: metascience

description: In this project, we're examining some of the behavioral dynamics of question and answer sessions at scientific conferences.
Exfoliation syndrome: assembling the puzzle pieces
Creators: name: Ritch, Robert
name: Borrás, Terete
name: Wiggs, Janey L.
name: Pasquale, Louis R.
name: Fingert, John H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: PURPOSE: To summarize various topics and the cutting edge approaches to refine XFS pathogenesis that were discussed at the 21st annual Glaucoma Foundation Think Tank meeting in New York City, Sept. 19-20, 2014.

METHODS: The highlights of three categories of talks on cutting edge research in the field were summarized.

RESULTS: Exfoliation syndrome (XFS) is a systemic disorder with a substantial ocular burden, including high rates of cataract, cataract surgery complications, glaucoma and retinal vein occlusion. New information about XFS is akin to puzzle pieces that do not quite join together to reveal a clear picture regarding how exfoliation material (XFM) forms.

CONCLUSION: Meeting participants concluded that it is unclear how the mild homocysteinemia seen in XFS might contribute to the disarrayed extracellular aggregates characteristic of this syndrome. Lysyl oxidase-like 1 (LOXL1) variants are unequivocally genetic risk factors for XFS but exactly how these variants contribute to the assembly of exfoliation material (XFM) remains unclear. Variants in a new genomic region, CACNA1A associated with XFS, may alter calcium concentrations at the cell surface and facilitate XFM formation but much more work is needed before we can place this new finding in proper context. It is hoped that various animal model and ex vivo systems will emerge that will allow for proper assembly of the puzzle pieces into a coherent picture of XFS pathogenesis. A clear understanding of XFS pathogenesis may lead to 'upstream solutions' to reduce the ocular morbidity produced by XFS.
Three-dimensional simulations of scattering polarization and the Hanle effect in MHD chromospheric models
Creators: name: Štěpán, Jiří
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Scattering line polarization and the Hanle effect are among the most important mechanisms for diagnostics of the solar and stellar atmospheres. The fact that real stellar atmospheres are horizontally inhomogeneous makes the spectral synthesis and interpretation very challenging because the effect of thermodynamic fluctuations on spectral line polarization is entangled with the action of magnetic fields. This applies to the spatially resolved as well as to the averaged spectra. The necessary step towards the interpretation of such spectra is to study the line formation in sufficiently realistic 3D MHD models and comparison of the synthetic spectra with observations. This paper gives an overview of recent progress in the field of 3D NLTE synthesis of polarized spectral lines resulting from investigations with the radiative transfer code PORTA.
description: 8 pages, 6 figures
Nikolskii inequality and functional classes on compact Lie groups
Creators: name: Nursultanov, E. D.
name: Ruzhansky, M. V.
name: Tikhonov, S. Yu.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: Analysis of PDEs (math.AP)
subject: Classical Analysis and ODEs (math.CA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In this note we study Besov, Triebel-Lizorkin, Wiener, and Beurling function spaces on compact Lie groups. A major role in the analysis is played by the Nikolskii inequality.
description: In this note (to appear in Funct. Anal. Appl.) we present results from our paper at arXiv:1403.3430 (to appear in Ann. Sc. Norm. Super. Pisa Cl. Sci.) in the simplified setting of compact Lie groups. We refer to the above paper for more general formulations in the setting of compact homogeneous manifolds and for the proofs
Codebook for Analyzing Content and Function of Communication in Social-Ecological Dilemma Experiments
Creators: name: DeCaro, Daniel
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: This codebook was developed through an iterative process (defining and then testing and further refining the definitions and coding procedures) as described by multiple guides (Ratajczyk et al. 2016, Tschan et al. 2018). This codebook is a product of a larger research project with Co-PIs Marco A. Janssen, and Allen Lee, funded by the National Science Foundation: Psychosocial, motivational, and cooperative effects of communication, enforcement, and participatory decision making in resource dilemmas. (2017-2022). National Science Foundation (NSF): Decision, Risk & Management Sciences (Award #1658608) This material is based upon work supported by the National Science Foundation under Grant No. 1658608. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
The impact of the increasing burden of trauma in Malawi on orthopedic trauma service priorities at Kamuzu Central Hospital
Creators: name: Manda, Kumbukani G
name: Gallaher, Jared
name: Munthali, Boston S
name: Charles, Anthony
name: Young, Sven
name: Banza, Leonard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Background and purpose — The burden of road traffic injuries globally is rising rapidly, and has a huge effect on health systems and development in low- and middle-income countries. Malawi is a small low-income country in southeastern Africa with a population of 16.7 million and a gross national income per capita of only 250 USD. The impact of the rising burden of trauma is very apparent to healthcare workers on the ground, but there are very few data showing this development.
Coupling and exponential ergodicity for stochastic differential equations driven by Lévy processes
Creators: name: Majka, Mateusz B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G51, 60H10

description: We present a novel idea for a coupling of solutions of stochastic differential equations driven by Lévy noise, inspired by some results from the optimal transportation theory. Then we use this coupling to obtain exponential contractivity of the semigroups associated with these solutions with respect to an appropriately chosen Kantorovich distance. As a corollary, we obtain exponential convergence rates in the total variation and standard $L^1$-Wasserstein distances.
description: 40 pages, revised version, accepted for publication in Stochastic Processes and their Applications. The final manuscript is available at Elsevier via https://doi.org/10.1016/j.spa.2017.03.020
Antecedents of inflammation biomarkers in preterm newborns on days 21 and 28
Creators: name: Leviton, Alan
name: Dammann, Olaf
name: O'Shea, T. Michael
name: Kuban, Karl C.K.
name: Fichorova, Raina N.
name: Allred, Elizabeth N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Most studies of systemic inflammation in very preterm newborns focus on assessments made during the first two weeks. The purpose of this study was to identify some of the antecedents of systemic inflammation evident during postnatal weeks three and four.
Fault-Tolerant High Level Quantum Circuits: Form, Compilation and Description
Creators: name: Paler, Alexandru
name: Polian, Ilia
name: Nemoto, Kae
name: Devitt, Simon J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Fault-tolerant quantum error correction is a necessity for any quantum architecture destined to tackle interesting, large-scale problems. Its theoretical formalism has been well founded for nearly two decades. However, we still do not have an appropriate compiler to produce a fault-tolerant, error corrected description from a higher level quantum circuit for state of the art hardware models. There are many technical hurdles, including dynamic circuit constructions that occur when constructing fault-tolerant circuits with commonly used error correcting codes. We introduce a package that converts high level quantum circuits consisting of commonly used gates into a form employing all decompositions and ancillary protocols needed for fault-tolerant error correction. We call this form the (I)initialisation, (C)NOT, (M)measurement form (ICM) and consists of an initialisation layer of qubits into one of four distinct states, a massive, deterministic array of CNOT operations and a series of time ordered $X$- or $Z$-basis measurements. The form allows a more flexbile approach towards circuit optimisation. At the same time, the package outputs a standard circuit or a canonical geometric description which is a necessity for operating current state-of-the-art hardware architectures using topological quantum codes.
description: 17 pages, 17 figures, comments welcome. The compiler source code is released under the Microsoft Reference Source License (Ms-RSL, http://referencesource.microsoft.com/ license.html) at http://www.teqcnique.com/icmconvert
Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21 st  International Symposium on Microsomes and Drug Oxidations (MDO)
Creators: name: Jeong, Hyunyoung
name: Xie, Wen
name: Zanger, Ulrich M.
name: Zhong, Xiao-bo
name: Aleksunes, Lauren M.
name: Morgan, Edward T.
name: Bhatt, Aadra P.
name: Wang, Li
name: Waxman, David J.
name: Yu, Ai-Ming
name: Hao, Pengying
name: Cherrington, Nathan J.
name: Klaassen, Curtis D.
name: Turnbaugh, Peter J.
name: Redinbo, Matthew R.
name: Ingelman-Sundberg, Magnus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Variations in drug metabolism may alter drug efficacy and cause toxicity better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.
Determinants of Profitability: Evidence from Large Manufacturing Food and Beverage Companies of Addis Ababa
Creators: name: Yodit Yirgu
Publisher: name: Zenodo
Year: 2017

description: Determinants of Profitability: Evidence from Large Manufacturing food and beverage Companies of Addis Ababa. This study sets out to examine the determinants of food and beverages profitability specifically focused on large manufacturing companies of the sector who submitted their annual financial statement reportto ERCA LTO, during the period 2011-2015. Consequently,the researcher used secondary data obtained from the financial statements (Balance sheet and Profit/Loss account) of food and beverage companies, and financial publications of CSA, MOFED and MOT. Quantitative research approach was adopted.The study performs a panel least square regression analysis to examine the proposed relationship. The study had a population size of 29 food and beveragecompanies operating in Addis Ababa. Simple random sampling technique was used to select the sampled companies from the period of 2011-2015, consisting of 14 companies with 70 observations.The results of panel least square regression analysis showed that: Firm size, Leverage and capital intensity, have statistically significant and negative impact on profitability. On the other hand, Managerial efficiency has a positive and statistically significant impact on manufacturing food and beverage companies’ profitability. The study concluded that size may have no or negative impact on profitability, managerial efficiency has strong effect on profitability. Beside the study suggested for the stakeholders that give more attention on the major variables of the sectors such as firm size and capital intensity.
Doppler Imaging with easily accessible instrumentation
Creators: name: Kriskovics, Levente
name: Kővári, Zsolt
name: Görgei, Anna
name: Oláh, Katalin
name: Seli, Bálint
name: Vida, Krisztián
name: Bódi, Attila
Publisher: name: Zenodo
Year: 2023
Subjects: stellar activity, Doppler imaging

description: Doppler imaging is still one of the most widely used spot modeling technique to date. However, its
 application is restricted by the fact (among others) that it requires time series of high-resolution spectra in
 order to properly resolve surface features. With the limited number of high resolution spectrographs, this
 severely limits its applications. Here we carry out tests to see how the lower resolution blurs the details of
 the Doppler images derived with our code iMAP. We also present three inversions for time series spectra
 taken with the echelle spectrograph (R=21k) mounted on the 1m RCC telescope at Piszkéstető Mountain
 Station, Hungary.
description: {"references": ["Carroll et al. 2012, A&A, 548, 95", "J\u00e4rvinen et al. 2007, A&A, 472, 887", "J\u00e4rvinen et al. 2018. A&A, 620, 162", "K\u0151v\u00e1ri et al. 2013. A&A, 551, 2", "Kriskovics et al. 2019. A&A, 627, 52", "Kupka et al. 1999. A&AS, 138, 119", "Strassmeier et al. 2019. A&A, 625, 27"]}
On Iwahori-Whittaker Functions for Metaplectic Groups
Creators: name: Patnaik, Manish M.
name: Puskás, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We relate Iwahori-Whittaker functions on metaplectic covers to certain Demazure-Lusztig operators, the latter of which are built from a Weyl group action previously considered by G. Chinta and P. Gunnells. Using a certain combinatorial identity for the sum of these Demazure-Lusztig operators, we obtain an analogue of the Casselman-Shalika formula for spherical Whittaker functions in this context.
description: Previous version had title "On the Casselman-Shalika formula for metaplectic groups"
The role of trauma and stress in development of chronic pain in LGBTQ2S+: A scoping review
Creators: name: Miller, Jillian
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: abuse
subject: adverse childhood experiences
subject: bisexual
subject: chronic pain
subject: domestic violence
subject: emotional abuse
subject: gay
subject: gender identity
subject: lesbian
subject: pain
subject: physical abuse
subject: post-traumatic stress disorder
subject: post-traumatic stress symptoms
subject: queer
subject: sexual abuse
subject: sexual identity
subject: sexual orientation
subject: socioeconomic status
subject: stress
subject: transexual
subject: transgender
subject: trauma

description: A scoping review of the literature to examine the role of trauma and stress in the development of chronic pain in persons identifying as LGBTQ2S+.
The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signaling
Creators: name: Wang, Ying
name: Wang, Yue-hu
name: Ming, Xin
name: Su, Xing-li
name: Kong, Yi
name: Su, Wen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Psm2, one of the pyrrolidinoindoline alkaloids isolated from whole Selaginella moellendorffii plants, has shown a potent antiplatelet activity. In this study, we further evaluated the antiplatelet effects of Psm2, and elucidated the underlying mechanisms.
title: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 56 Nr. 1 (1978)
title: Bd. 56 Nr. 1 (1978)
titleType: AlternativeTitle
Creators: name: Germania : Anzeiger Der Römisch-Germanischen Kommission Des Deutschen Archäologischen Instituts
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Attila Kiss, Avar Cemeteries in County Baranya...312-314 Ludwig Buisson, Der Bildstein Ardre VIII auf Gotland...306-311 Anton Gnirs, Beiträge zur Geschichte und Geographie Böhmens und Mährens in der Zeit des Imperium Romanum...294-296 Roger Agache und Bruno Bréart, Atlas d’Archéologie Aérienne de Picardie...290 Gerald Simpson, Watermills and Military Works on Hadrian’s Wall...289-290 L M. Stead, Excavations at Winterton Roman Villa and other Roman sites in North Lincolnshire 1958-1967...287-289 Iron Age and Romano-British Monuments in the Gloucestershire Cotswolds...286-287 Atlante aereofotografico delle sedi umane in Italia...281-284 Renato Peroni, Studi di cronologia hallstattiana...269-280 G. J. Wainwright and I. H. Longworth, Durrington Walls: Excavations 1966-1968...256-258 Zum „Abschnittswall im Walde Brand" des Katalogs Eichstätt von Friedrich Winkelmann...235-238 Eine Tüllengeweihaxt aus Fund mit Stichbandkeramik von Menning an der Donau (Oberbayern)...234-235 Inhalt...V-VI Titelei
Conjugated polymer nanomaterials for theranostics
Creators: name: Gu, Zhen
name: Yu, Ji-cheng
name: Xiao, Xuan-zhong
name: Feng, Pei-jian
name: Dong, Mei
name: Chen, Yu-lei
name: Shen, Qun-dong
name: Hu, Quan-yin
name: Qian, Cheng-gen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrared (NIR) imaging, two-photon (TP) imaging, photoacoustic (PA) imaging, and multimodal (MM) imaging, are introduced. Then, CPN-based photodynamic therapy (PDT) and photothermal therapy (PTT) are surveyed. A variety of stimuli-responsive CPN systems for drug delivery are also summarized, and the promising trends and translational challenges are discussed.
Multimodalität und Rezeptionsbedingungen
Creators: name: Soubeyrand, Ladina
Publisher: name: Zenodo
Year: 2023
Subjects: Multimodalität
Kirchenraum
Systemic Functional Linguistics
Field Tenor Mode Model
St. Marienkirche Berlin
Kommunikationsraum

description: Dieses Poster setzt sich mit der Frage auseinander, inwieweitdie multimodale Rezeption der Epitaphie deren Kommunikation im Kirchenraum beeinflusst?
description: Posterpräsentation der X-Student Research Group "Berliner Inschriften als Quelle für die historische Registerforschung" (Gohar Schnelle, Dina Serova, finanziert durch die Berlin University Alliance) am 03.04.2023.