cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stable topological modes in two-dimensional Ginzburg-Landau models with trapping potentials
Creators: name: Mihalache, D.
name: Mazilu, D.
name: Skarka, V.
name: Malomed, B. A.
name: Leblond, H.
name: Aleksić, N. B.
name: Lederer, F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Complex Ginzburg-Landau (CGL) models of laser media (with the cubic-quintic nonlinearity) do not contain an effective diffusion term, which makes all vortex solitons unstable in these models. Recently, it has been demonstrated that the addition of a two-dimensional periodic potential, which may be induced by a transverse grating in the laser cavity, to the CGL equation stabilizes compound (four-peak) vortices, but the most fundamental "crater-shaped" vortices (CSVs), alias vortex rings, which are, essentially, squeezed into a single cell of the potential, have not been found before in a stable form. In this work we report families of stable compact CSVs with vorticity S=1 in the CGL model with the external potential of two different types: an axisymmetric parabolic trap, and the periodic potential. In both cases, we identify stability region for the CSVs and for the fundamental solitons (S=0). Those CSVs which are unstable in the axisymmetric potential break up into robust dipoles. All the vortices with S=2 are unstable, splitting into tripoles. Stability regions for the dipoles and tripoles are identified too. The periodic potential cannot stabilize CSVs with S>=2 either; instead, families of stable compact square-shaped quadrupoles are found.
Mass and metal ejection efficiency in disk galaxies driven by young stellar clusters of nuclear starburst
Creators: name: Rodriguez-Gonzalez, A.
name: Esquivel, A.
name: Raga, A. C.
name: Colin, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present results from models of galactic winds driven by energy injected by nuclear starbursts. The total energy of the starburst is provided by young central stellar clusters and parts of the galactic interstellar medium are pushed out as part of the galactic wind (in some cases the galactic wind contains an important part of the metals produced in the new generation of stars). We have performed adiabatic and radiative 3D N-Body/Smooth Particle Hydrodynamics simulations of galactic winds using the GADGET-2 code. The numerical models cover a wide range of starburst (from $\sim10^2$ to $\sim10^7$ M$_\odot$) and galactic gas masses (from $\sim6\times10^6$ to $\sim10^{11}$ M$_\odot$). The concentrated central starburst regions are an efficient engine for producing of the mass and metal loss in galaxies, and also for driving the metal redistribution in the galaxies.
description: 15 pages, 7 figures, (in press)
Error analysis of a partial pivoting method for structured matrices
Creators: name: Sweet, Douglas R.
name: Brent, Richard P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: F.2.1
subject: 65F05 (Primary) 15B05, 65G50 (Secondary)

description: Many matrices that arise in the solution of signal processing problems have a special displacement structure. For example, adaptive filtering and direction-of-arrival estimation yield matrices of Toeplitz type. A recent method of Gohberg, Kailath and Olshevsky (GKO) allows fast Gaussian elimination with partial pivoting for such structured matrices. In this paper, a rounding error analysis is performed on the Cauchy and Toeplitz variants of the GKO method. It is shown the error growth depends on the growth in certain auxiliary vectors, the generators, which are computed by the GKO algorithms. It is also shown that in certain circumstances, the growth in the generators can be large, and so the error growth is much larger than would be encountered with normal Gaussian elimination with partial pivoting. A modification of the algorithm to perform a type of row-column pivoting is proposed; it may ameliorate this problem.
description: 18 pages. An old Technical Report, submitted for archival purposes. For further details see http://wwwmaths.anu.edu.au/~brent/pub/pub157.html
A new cytotoxic plumbagin derivative from roots of Diospyros undulata
Creators: name: Suchaichit, Nattawut
name: Suchaichit, Natcha P.
name: Kanokmedhakul, Kwanjai
name: Boottanun, Patcharaporn
name: Sermswan, Rasana W.
name: Moosophon, Panawan
name: Kanokmedhakul, Somdej
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A new plumbagin derivative, 3-(5-oxohexyl)plumbagin (1), together with six known benzoquinone derivatives (2–7), four known triterpenoids (8–11) and coniferyl aldehyde (12) were isolated from Diospyros undulata roots. Their structures were elucidated by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. Compound 1 exhibited strong cytotoxicity against three cancer cell lines as lung cancer (NCI-H187), breast cancer (MCF-7), and oral cancer (KB) with IC50 values of 7.16, 12.85 and 28.67 µM, respectively. Moreover, it did not showed cytotoxicity to Vero cells. In addition, the antimicrobial activity of compound 1 was moderate that kill only S. aureus with MBC of 250 µg/mL while other compounds especially compound 4 showed a broader activity that kill all tested bacteria.
Quantum fluctuations can promote or inhibit glass formation
Creators: name: Markland, Thomas E.
name: Morrone, Joseph A.
name: Berne, B. J.
name: Miyazaki, Kunimasa
name: Rabani, Eran
name: Reichman, David R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The very nature of glass is somewhat mysterious: while relaxation times in glasses are of sufficient magnitude that large-scale motion on the atomic level is essentially as slow as it is in the crystalline state, the structure of glass appears barely different than that of the liquid that produced it. Quantum mechanical systems ranging from electron liquids to superfluid helium appear to form glasses, but as yet no unifying framework exists connecting classical and quantum regimes of vitrification. Here we develop new insights from theory and simulation into the quantum glass transition that surprisingly reveal distinct regions where quantum fluctuations can either promote or inhibit glass formation.
description: Accepted for publication in Nature Physics. 22 pages, 3 figures, 1 Table
Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay
Creators: name: Stuber, G.
name: Leder, G. H.
name: Storkus, W. T.
name: Lotze, M. T.
name: Modrow, Susanne
name: Székely, L.
name: Wolf, Hans J.
name: Klein, E.
name: Kärre, K.
name: Klein, G.
Publisher: name: Universität Regensburg
Year: 1994
Subjects: subject: 610 Medizin
subject: Amino Acid Sequence
subject: Cell Line
subject: HLA-A2 Antigen/immunology
subject: Humans
subject: Molecular Sequence Data
subject: Peptides/immunology
subject: Protein Binding
subject: Structure-Activity Relationship
subject: Tumor Suppressor Protein p53/immunology

description: Mutations of the p53 gene are the most frequently observed genetic changes in human cancers; often leading to an overexpression of the wild-type (wt) p53 protein. Demonstrable T cell reactivity against tumor cells overexpressing wt or mutant p53-derived peptides could support the application of such epitopes in cancer immunotherapies. As the binding of peptide to MHC class I molecules is a prerequisite for antigen-specific T cell recognition, we evaluated the ability of wt and mutant p53 peptides to bind to HLA-A2.1 using two independent flow cytometry-based assay systems, the T2 major histocompatibility complex (MHC) class I peptide stabilization assay (stabilization assay) and the peptide-induced MHC class I reconstitution assay (reconstitution assay). The twenty selected wt sequences each conformed to the previously reported HLA-A2.1 peptide binding motif. Seven of the wt p53 and 2/13 mutant p53 peptides derived from the previously chosen wt peptides bound to HLA-A2.1 in both the stabilization and the reconstitution assays. An additional six wt and six mutant p53 peptides, presumably exhibiting lower affinity for HLA-A2.1, were identified only in the reconstitution assay. Those p53 peptides binding HLA-A2.1 may provide useful immunogens for the generation of HLA-A2.1-restricted cytolytic T lymphocytes in vitro and in vivo.
DAMPAK PANDEMI COVID-19 TERHADAP DUNIA USAHA DI INDONESIA
Creators: name: Hapiz
Publisher: name: Zenodo
Year: 2022
Subjects: Kewirausahaan

description: Tugas UAS Makalah Individu / Hapiz (11812061) / PBA 7C / Kewirausahaan / Dosen Pengampu : Dr. Fachrurazi, S.Ag., MM dan Yulida, MM. FTIK - IAIN Pontianak, 2022
Roper Reports 93-4
Creators: name: Organization, The Roper
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: President Bill Clinton job performance (1); Clinton economic plan and taxes (16); community crime (2); credit cards (24); food safety (2); health and safety issues such as radon, asbestos, etc. (19); brand name products and choices (26); personal appearance (15).
Probing the Nature of Short Swift Bursts via Deep INTEGRAL Monitoring of GRB 050925
Creators: name: Sakamoto, T.
name: Barbier, L.
name: Barthelmy, S. D.
name: Cummings, J. R.
name: Fenimore, E. E.
name: Gehrels, N.
name: Krimm, H. A.
name: Markwardt, C. B.
name: Palmer, D. M.
name: Parsons, A. M.
name: Sato, G.
name: Stamatikos, M.
name: Tueller, J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present results from Swift, XMM-Newton, and deep INTEGRAL monitoring in the region of GRB 050925. This short Swift burst is a candidate for a newly discovered soft gamma-ray repeater (SGR) with the following observational burst properties: 1) galactic plane (b=-0.1 deg) localization, 2) 150 msec duration, and 3) a blackbody rather than a simple power-law spectral shape (with a significance level of 97%). We found two possible X-ray counterparts of GRB 050925 by comparing the X-ray images from Swift XRT and XMM-Newton. Both X-ray sources show the transient behavior with a power-law decay index shallower than -1. We found no hard X-ray emission nor any additional burst from the location of GRB 050925 in ~5 Ms of INTEGRAL data. We discuss about the three BATSE short bursts which might be associated with GRB 050925, based on their location and the duration. Assuming GRB 050925 is associated with the H II regions (W 58) at the galactic longitude of l=70 deg, we also discuss the source frame properties of GRB 050925.
description: 13 pages, 13 figures, accepted for publication in ASR special issue on Neutron Stars and Gamma Ray Bursts, full resolution of Fig 5 is available at http://asd.gsfc.nasa.gov/Takanori.Sakamoto/GRB050925/integral_ibis_images.eps
Multimodal Misinformation Detection in a South African Social Media Environment
Creators: name: De Jager, Amica
name: Marivate, Vukosi
name: Modupe, Abioudun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: With the constant spread of misinformation on social media networks, a need has arisen to continuously assess the veracity of digital content. This need has inspired numerous research efforts on the development of misinformation detection (MD) models. However, many models do not use all information available to them and existing research contains a lack of relevant datasets to train the models, specifically within the South African social media environment. The aim of this paper is to investigate the transferability of knowledge of a MD model between different contextual environments. This research contributes a multimodal MD model capable of functioning in the South African social media environment, as well as introduces a South African misinformation dataset. The model makes use of multiple sources of information for misinformation detection, namely: textual and visual elements. It uses bidirectional encoder representations from transformers (BERT) as the textual encoder and a residual network (ResNet) as the visual encoder. The model is trained and evaluated on the Fakeddit dataset and a South African misinformation dataset. Results show that using South African samples in the training of the model increases model performance, in a South African contextual environment, and that a multimodal model retains significantly more knowledge than both the textual and visual unimodal models. Our study suggests that the performance of a misinformation detection model is influenced by the cultural nuances of its operating environment and multimodal models assist in the transferability of knowledge between different contextual environments. Therefore, local data should be incorporated into the training process of a misinformation detection model in order to optimize model performance.
description: Artificial Intelligence Research. SACAIR 2023
Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus Paecilomyces sp
Creators: name: Braun, Glaucia H.
name: Ramos, Henrique P.
name: Candido, Ana C. B. B.
name: Pedroso, Rita C. N.
name: Siqueira, Kátia A.
name: Soares, Marcos A.
name: Dias, Gustavo M.
name: Magalhães, Lizandra G.
name: Ambrósio, Sérgio R.
name: Januário, Ana H.
name: Pietro, Rosemeire C. L. R.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Fractionation of extracts from the culture broth of the marine-derived fungus, Paecilomyces sp. 7A22, resulted in the isolation of the harzialactone A (HA), a known compound previously isolated from fungi of marine environments. The chemical structure of HA was determined by spectroscopic analyses. Upon evaluation of HA on antileishmanial assays against Leishmania amazonensis, HA exhibited significant activity against promastigotes forms with IC50 of 5.25 µg mL−1 and moderate activity against intracellular amastigotes with IC50 of 18.18 µg mL−1. This is the first report on the antileishmanial activity of HA, and the effects of HA presented in this work suggest that this class of compounds are suitable for future biological in vitro and in vivo studies for the search of natural products with activity against Leishmania spp. Furthermore, the present results corroborate marine-derived fungi as a promising source of natural products with antiparasitic activity.
The ERASMUS+ SIDECar project - A Manual for the exploitation of the framework
Creators: name: Janssen, Niels
name: Ottoboni, Giovanni
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2021
Subjects: LS5_11 Neurological disorders (e.g. Alzheimer’s disease, Huntington’s disease, Parkinson’s disease)
M-PED/04 Pedagogia sperimentale
M-PSI/08 Psicologia clinica
SH4_5 Social and clinical psychology

description: Before you lay the manual about the ERASMUS+ SIDECar project, we remind you that the SIDECar project aimed at developing a transnational curriculum on psycho-social education in dementia. In the manual, the project will be presented, including the curriculum and Platform on which the material is stored. The SIDECar curriculum: a quick overview The SIDECar curriculum comprises three online Modules with 17 topics (Module 1 “Living well with dementia”: seven topics; Module 2 “Living well with PwD”: six topics, and Module 3 ”Positive working with PwD and their family members”: four topics). The Modules can be followed consecutively, but can also be followed in a flexible way, for example choosing the topics that align with the interests or needs. Each topic is developed by experts from one of the partners’ countries, and is based on the latest insights. Topics range from theoretical perspectives to more practical topics and include videos and other material. Please see Chapter 2 for an overview of all Modules and topics. How can the Material be accessed? The three Modules, including the learning material, can be accessed through the specifically developed online Platform. All material is freely accessible, and ready to be used, allowing for flexibility in studying. To access the material, registration is, however, required. Please see Chapter 3 for more information about the Platform. For whom is Sidecar intended? The online Sidecar curriculum is intended mainly for students from Higher Education living or studying in Europe. It can also be useful for professionals working in the field of dementia care who want to learn more about this topic, and for teachers who are not experts in psycho-social care for dementia but are keen to offer their students learning materials for psycho-social education in dementia. Please see Chapter 6 for recommendations for using the Sidecar material.
Evaluating the therapeutic use of Indoleamine 2,3-dioxygenase (IDO) expressing allogenic dermal fibroblast populated within an acellular skin substitute as a wound coverage
Creators: name: Farrokhi, Ali
Publisher: name: University of British Columbia
Year: 2018

description: Acute and chronic wounds contribute to increased morbidity and mortality in affected people and impose significant financial burdens on healthcare systems. Allogeneic cell-based skin substitutes have been proposed as ready-to-use wound coverage as an alternative to conventional split-thickness skin grafts, but the survival and usefulness of such cells after transplantation into an immunocompetent host remain controversial. We hypothesize that the application of an indoleamine 2,3-dioxygenase (IDO) expressing allogenic dermal fibroblast populated within an acellular dermal matrix (ADM) is sufficient to create an immune-privileged area within the wound to protect fibroblasts from rejection. Fibroblasts in the skin substitute can potentially assist the graft to restore its function by synthesizing extracellular matrix components and growth factors. In this study, ADMs were prepared using a novel detergent–free method, recellularized with IDO-expressing or control fibroblasts from C57/B6 mice, and were transplanted on splinted full-thickness skin wounds in Balb/c mice. Transplantation studies demonstrated that ADM significantly enhanced the wound-healing process but there was no demonstrable benefit when the ADM was recellularized with fibroblasts. Investigating the transplanted cells’ fate by bioluminescence in vivo imaging after intra-hypo-dermal injection of fibroblasts in to mouse skin revealed that both type of fibroblasts were rejected in allogeneic recipients while in immunodeficient NOD-SCID-Il2r gamma null (NSG) mice they were not. Allogeneic fibroblasts transplanted in natural killer T cell and gamma delta T (NKT) cell deficient mice were rejected as well. Depleting natural killer (NK) cells or CD4+ T cells could delay the rejection but not prevent it. Double depletion of CD4+ and CD8+ cells could partially prevent the rejection. Analyzing the infiltrated immune cells to graft region in time of cell rejection revealed the presence of high number of monocytes, macrophage and neutrophils. Our data indicate a clear immune response to allogeneic fibroblasts in which both innate and T-cell immune response are involved in targeting cells. Although it has been reported by other researchers that IDO-expressing cells exhibit strong immunosuppressive activity in vitro and in vivo, we documented rejection of these cells in our study, suggesting that the application of these cells in wound sites requires further improvements.
Pairwise wave interactions in ideal polytropic gases
Creators: name: Chen, Geng
name: Endres, Erik E.
name: Jenssen, Helge Kristian
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We consider the problem of resolving all pairwise interactions of shock waves, contact waves, and rarefaction waves in 1-dimensional flow of an ideal polytropic gas. Resolving an interaction means here to determine the types of the three outgoing (backward, contact, and forward) waves in the Riemann problem defined by the extreme left and right states of the two incoming waves, together with possible vacuum formation. This problem has been considered by several authors and turns out to be surprisingly involved. For each type of interaction (head-on, involving a contact, or overtaking) the outcome depends on the strengths of the incoming waves. In the case of overtaking waves the type of the reflected wave also depends on the value of the adiabatic constant. Our analysis provides a complete breakdown and gives the exact outcome of each interaction.
description: 39 pages
Investigating the use of remote ischemic preconditioning to attenuate the decline in vascular function during hypoxia
Creators: name: Rieger, Mathew
Publisher: name: University of British Columbia
Year: 2017

description: Application of repeated short duration bouts of ischemia to the limbs, termed remote ischemic preconditioning (RIPC), is a novel technique that may have protective effects on vascular function during hypoxic exposures. In separate parallel-design studies, at sea-level (SL; n=16), and after 8-12 days at high-altitude (HA; n=12; White Mountain, 3800m), participants underwent either a sham protocol or one session of 4x5 minutes of dual-thigh cuff occlusion with 5-minutes recovery. Brachial artery flow-mediated dilation (FMD; ultrasound), pulmonary artery systolic pressure (PASP; echocardiography), and internal carotid artery flow (ICA; ultrasound) were measured at SL in normoxia and isocapnic hypoxia [end-tidal PO₂ (PETO₂) maintained to 50mmHg], and during normal breathing at HA. The hypoxic ventilatory response (HVR) was measured at each location. All measures at SL and HA were obtained at baseline (BL), 1 hour, 24 hours, and 48 hours post-RIPC or sham. At SL, RIPC produced no changes in FMD, PASP, ICA flow, end-tidal gases or HVR in normoxia or hypoxia. At HA, although HVR increased 24 hours post RIPC compared to BL (2.05±1.4 vs. 3.21±1.2 L·min-1·%SaO2-1, p<0.01), there were no significant differences in FMD, PASP, ICA flow, resting end-tidal gases. Accordingly, a single session of RIPC is insufficient to evoke changes in peripheral, pulmonary, and cerebral vascular function in healthy adults. Although chemosensitivity may increase following RIPC at HA, this did not confer any vascular changes. Under the current testing situations, for healthy and asymptomatic participants, the utility of a single RIPC session seems unremarkable during acute and chronic hypoxia.
Astrophysical Parameters and Habitable Zone of the Exoplanet Hosting Star GJ 581
Creators: name: von Braun, Kaspar
name: Boyajian, Tabetha S.
name: Kane, Stephen R.
name: van Belle, Gerard T.
name: Ciardi, David R.
name: Lopez-Morales, Mercedes
name: McAlister, Harold A.
name: Henry, Todd J.
name: Jao, Wei-Chun
name: Riedel, Adric R.
name: Subasavage, John P.
name: Schaefer, Gail
name: Brummelaar, Theo A. ten
name: Ridgway, Stephen
name: Sturmann, Lazlo
name: Sturmann, Judit
name: Mazingue, Jude
name: Turner, Nils H.
name: Farrington, Chris
name: Goldfinger, P. J.
name: Boden, Andrew F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: GJ 581 is an M dwarf host of a multiplanet system. We use long-baseline interferometric measurements from the CHARA Array, coupled with trigonometric parallax information, to directly determine its physical radius to be $0.299 \pm 0.010 R_{\odot}$. Literature photometry data are used to perform spectral energy distribution fitting in order to determine GJ 581's effective surface temperature $T_{\rm EFF}=3498 \pm 56$ K and its luminosity $L=0.01205 \pm 0.00024 L_{\odot}$. From these measurements, we recompute the location and extent of the system's habitable zone and conclude that two of the planets orbiting GJ 581, planets d and g, spend all or part of their orbit within or just on the edge of the habitable zone.
description: 10 pages, 3 figures, 2 tables; accepted for publication in ApJL
DiscoBAX: Discovery of Optimal Intervention Sets in Genomic Experiment Design
Creators: name: Lyle, Clare
name: Mehrjou, Arash
name: Notin, Pascal
name: Jesson, Andrew
name: Bauer, Stefan
name: Gal, Yarin
name: Schwab, Patrick
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Machine Learning (cs.LG)
subject: Methodology (stat.ME)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: The discovery of therapeutics to treat genetically-driven pathologies relies on identifying genes involved in the underlying disease mechanisms. Existing approaches search over the billions of potential interventions to maximize the expected influence on the target phenotype. However, to reduce the risk of failure in future stages of trials, practical experiment design aims to find a set of interventions that maximally change a target phenotype via diverse mechanisms. We propose DiscoBAX, a sample-efficient method for maximizing the rate of significant discoveries per experiment while simultaneously probing for a wide range of diverse mechanisms during a genomic experiment campaign. We provide theoretical guarantees of approximate optimality under standard assumptions, and conduct a comprehensive experimental evaluation covering both synthetic as well as real-world experimental design tasks. DiscoBAX outperforms existing state-of-the-art methods for experimental design, selecting effective and diverse perturbations in biological systems.
A new cytotoxic plumbagin derivative from roots of Diospyros undulata
Creators: name: Suchaichit, Nattawut
name: Suchaichit, Natcha P.
name: Kanokmedhakul, Kwanjai
name: Boottanun, Patcharaporn
name: W. Sermswan, Rasana
name: Moosophon, Panawan
name: Kanokmedhakul, Somdej
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A new plumbagin derivative, 3-(5-oxohexyl)plumbagin (1), together with six known benzoquinone derivatives (2–7), four known triterpenoids (8–11) and coniferyl aldehyde (12) were isolated from Diospyros undulata roots. Their structures were elucidated by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. Compound 1 exhibited strong cytotoxicity against three cancer cell lines as lung cancer (NCI-H187), breast cancer (MCF-7), and oral cancer (KB) with IC50 values of 7.16, 12.85 and 28.67 µM, respectively. Moreover, it did not showed cytotoxicity to Vero cells. In addition, the antimicrobial activity of compound 1 was moderate that kill only S. aureus with MBC of 250 µg/mL while other compounds especially compound 4 showed a broader activity that kill all tested bacteria.
Bertha Edwards Riding on Bull
Creators: name: Springs Historical Society
Publisher: name: Unknown
Year: 0
Subjects: East Hampton
Springs
Edwards Family
Bulls
Horns (Animal)

description: This image shows Bertha Edwards riding a bull. She is the daughter of George B. Edwards and Martha Tuthill. She taught at Springs School and was the wife of Charles Howard Finch. This image is a reprint of the original.
description: This material was lent to the Long Island Collection by the Springs Historical Society Library for digitization purposes.
An examination of the relationships between neuropathic pain, exercise and affect in adults with spinal cord injury
Creators: name: Todd, Kendra Robyn
Publisher: name: University of British Columbia
Year: 2017

description: Purpose: Neuropathic pain affects up to 75% of individuals with a spinal cord injury (SCI), with many reporting pain as more disabling than the injury itself. Currently, treatments are primarily pharmaceutical, however exercise may alleviate neuropathic pain. Daily fluctuations in neuropathic pain are not well understood, specifically in relation to exercise participation. Additionally, the connection between exercise and affective mood states of adults with SCI is unclear. The purpose of this study was to utilize ecological momentary assessment to measure intra-individual diurnal variations in neuropathic pain sensations and affect. This study aimed to provide a deeper understanding of how neuropathic pain and affect change from pre- to post-exercise, and over time. Methods: Six physically active adults with SCI participated in a 6-day study protocol. They responded to six daily prompts between 9:00 AM and 9:00 PM, and before and after exercising, using the Smartphone application mEMA. The prompts required participants to answer the Feeling Scale, Felt Arousal Scale, and a modified version of the Neuropathic Pain Scale. Neuropathic pain scores were averaged into a composite score and data were analyzed by plotting neuropathic pain and affective scores over the 6 days. Paired samples t-tests were conducted to observe changes in neuropathic pain and affect from pre- to post-exercise. Bivariate Pearson’s correlational analyses were performed to observe if correlations existed between time of day, neuropathic pain and affect within-subjects. Results: Overall, participants experienced a significant decrease in neuropathic pain (t(5) = 3.93; p=0.011) following completion of at least one bout of exercise. However, two participants experienced an increase in neuropathic pain following one bout of exercise. With regards to affect, a large, but non-significant increase (Hgav=0.76) in Feeling Scale scores occurred following one bout of exercise. Changes in arousal were non-significant following exercise. Time of day, neuropathic pain and affect were significantly correlated for one participant. Conclusion: These results suggest that exercise can reduce neuropathic pain, and may also increase feelings of pleasure. Further research is needed to look at both individual characteristics, and characteristics of exercise that may moderate exercise-induced changes in neuropathic pain and affect for adults with SCI.
Degenerate Fermi Gas of $^{87}$Sr
Creators: name: DeSalvo, B. J.
name: Yan, M.
name: Mickelson, P. G.
name: de Escobar, Y. N. Martinez
name: Killian, T. C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We report quantum degeneracy in a gas of ultra-cold fermionic $^{87}$Sr atoms. By evaporatively cooling a mixture of spin states in an optical dipole trap for 10.5\,s, we obtain samples well into the degenerate regime with $T/T_F=0.26^{+.05}_{-.06}$. The main signature of degeneracy is a change in the momentum distribution as measured by time-of-flight imaging, and we also observe a decrease in evaporation efficiency below $T/T_F \sim 0.5$.
description: 4 pages, 3 figures
title: Integration of Base Excitation with nonlinear Coupling within the Multiharmonic Balance Method
Creators: name: Kubatschek, Tido
name: Albers, Tomke
name: Tatzko, Sebastian
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2025
Subjects: subject: 600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: [no abstract available]
Elucidation and characterization of genes associated with montbretin a biosynthesis within crocosmia x crocosmiiflora and white pine weevil defense in picea sitchensis
Creators: name: Roach, Christopher Robert
Publisher: name: University of British Columbia
Year: 2018

description: Plant-specialized metabolites have long been utilized as medicines, cosmetics, flavours, and industrial raw materials. To explore the biosynthesis of a specialized metabolite in a non-model system and utilize the biosynthetic genes for future application, genomics-informed research typically flows through three phases: i) development of genomic or transcriptomic resources, ii) discovery and characterization of biosynthetic genes, and iii) application of the genes and enzymes for improved production of the specialized metabolite. This thesis describes hypothesis-driven research along these three phases in two different plant species and two different metabolic systems. My research with Crocosmia x crocosmiiflora focused on resource development and discovery of biosynthetic genes of a specialized metabolite of interest, montbretin A (MbA). I developed new resources for this system including metabolite-profiles and transcriptome sequences and annotations. This work resulted in insight into the spatial and temporal patterns of MbA accumulation in C. x crocosmiiflora and a first reference transcriptome with annotation for this species. Using these resources, I functionally characterized four UDP-xylose synthases and five UDP-rhamnose synthases. I discuss the application of these genes for possible use in an improved MbA production system and provide a proof of concept for using these genes to enable characterization of downstream MbA biosynthetic genes. I also identified 14 UDP-glycosyltransferases as candidate MbA biosynthetic genes through a guilt-by-association analysis; however, their functional characterization did not support a role in MbA biosynthesis. In the second biological system, Sitka spruce (Picea sitchensis), I performed a detailed characterization of a set of monoterpene synthases involved in the biosynthesis of the (+)-3-carene. Using domain swapping and site-directed mutagenesis, I demonstrated the catalytic plasticity of monoterpene synthases across a family of (+)-3-carene synthase-like genes associated with P. sitchensis resistance against the white pine weevil (Pissodes strobi). This work identified a single amino acid as most critical in determining both product profile and enzyme kinetics. Furthermore, I described mechanisms by which this amino acid directs product profiles through differential stabilization of the reaction intermediate. The work presented highlights the inherent plasticity and potential for evolution of alternative product profiles of these monoterpene synthases of conifer defense against pests.
Fast Mixing of Parallel Glauber Dynamics and Low-Delay CSMA Scheduling
Creators: name: Jiang, Libin
name: Leconte, Mathieu
name: Ni, Jian
name: Srikant, R.
name: Walrand, Jean
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Glauber dynamics is a powerful tool to generate randomized, approximate solutions to combinatorially difficult problems. It has been used to analyze and design distributed CSMA (Carrier Sense Multiple Access) scheduling algorithms for multi-hop wireless networks. In this paper we derive bounds on the mixing time of a generalization of Glauber dynamics where multiple links are allowed to update their states in parallel and the fugacity of each link can be different. The results can be used to prove that the average queue length (and hence, the delay) under the parallel Glauber dynamics based CSMA grows polynomially in the number of links for wireless networks with bounded-degree interference graphs when the arrival rate lies in a fraction of the capacity region. We also show that in specific network topologies, the low-delay capacity region can be further improved.
description: 12 pages
Consumer acceptance of different insect-based foods: a cross-cultural study in China and France
Creators: name: Yan, X.
name: Federighi, M.
name: Cappelier, J.M.
name: Jury, V.
name: Boué, G.
Publisher: name: Brill Online
Year: 2024
Subjects: classificationCode: 309999
subject: Other agricultural, veterinary and food sciences not elsewhere classified

description: Consumption of edible insects as an alternative protein source has recently gained attention for its potential beneficial impacts on the environment, nutrition, and food security compared to traditional sources. However, despite being a traditional food in some parts of the world, its acceptance is still limited, especially in Europe. The present study aims to examine consumers’ willingness to eat (WTE) different insect-based foods (IBF) and investigate determining factors for acceptance in countries with or without entomophagy traditions. An online cross-cultural survey was conducted in France (n = 515) and China (n = 594) in April 2023. Several explanatory variables were established, and their effects on the acceptance of insect foods was analysed by applying multiple linear regression. The results showed that Chinese respondents had higher willingness to eat insects than French respondents, with a different preference ranking of thirteen IBFs. In both countries, significant predictors of consumers’ willingness to eat insects were the low insect visibility, low food neophobia and disgust level, previous experience of consuming insects and knowledge of insects’ nutritional and environmental benefits. Consequently, the inclusion of insects in the daily diet of French and Chinese consumers requires a transitional phase to familiarize consumers with processed foods containing invisible insects and establish positive perceptions of insect foods.
Voice Recognition Robot with Real-Time Surveillance and Automation
Creators: name: Basyal, Lochan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Voice recognition technology enables the execution of real-world operations through a single voice command. This paper introduces a voice recognition system that involves converting input voice signals into corresponding text using an Android application. The text messages are then transmitted through Bluetooth connectivity, serving as a communication platform. Simultaneously, a controller circuit, equipped with a Bluetooth module, receives the text signal and, following a coding mechanism, executes real-world operations. The paper extends the application of voice recognition to real-time surveillance and automation, incorporating obstacle detection and avoidance mechanisms, as well as control over lighting and horn functions through predefined voice commands. The proposed technique not only serves as an assistive tool for individuals with disabilities but also finds utility in industrial automation, enabling robots to perform specific tasks with precision.
description: 6 pages, 16 figures
On general local Tb theorems
Creators: name: Hytönen, Tuomas
name: Martikainen, Henri
Publisher: name: arXiv
Year: 2010
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 42B20, 42B25

description: In this paper, local Tb theorems are studied both in the doubling and non-doubling situation. We prove a local Tb theorem for the class of upper doubling measures. With such general measures, scale invariant testing conditions are required (L^{\infty} or BMO). In the case of doubling measures, we also modify the general non-homogeneous method of proof to yield a new proof of the local Tb theorem with L^2 type testing conditions.
description: 31 pages
Gamow-Teller Unit Cross Sections for (t,3He) and (3He,t) Reactions
Creators: name: Perdikakis, G.
name: Zegers, R. G. T.
name: Austin, Sam M.
name: Bazin, D.
name: Caesar, C.
name: Deaven, J. M.
name: Gade, A.
name: Galaviz, D.
name: Grinyer, G.
name: Guess, C. J.
name: Herlitzius, C.
name: Hitt, G. W.
name: Howard, M. E.
name: Meharchand, R.
name: Noji, S.
name: Sakai, H.
name: Shimbara, Y.
name: Smith, E. E.
name: Tur, C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The proportionality between differential cross sections at vanishing linear momentum transfer and Gamow-Teller transition strength, expressed in terms of the \textit{unit cross section} ($\hatσ_{GT}$) was studied as a function of target mass number for ($t$,$^{3}$He) and ($^{3}$He,$t$) reactions at 115 $A$MeV and 140 $A$MeV, respectively. Existing ($^{3}$He,$t$) and ($t$,$^{3}$He) data on targets with mass number $12\leq A\leq 120$ were complemented with new and reevaluated ($t$,$^{3}$He) data on proton, deuteron, $^{6}$Li and $^{12}$C targets. It was found that in spite of the small difference in beam energies between the two probes, the unit cross sections have a nearly identical and simple dependence on target mass number $A$, for $A\geq 12$: $\hatσ_{GT}=109/A^{0.65}$. The factorization of the unit cross sections in terms of a kinematical factor, a distortion factor and the strength of the effective spin-isospin transfer nucleus-nucleus interaction was investigated. Simple phenomenological functions depending on mass number $A$ were extracted for the latter two. By comparison with plane and distorted-wave Born approximation calculations, it was found that the use of a short-range approximation for knock-on exchange contributions to the transition amplitude results in overestimated cross sections for reactions involving the composite ($^{3}$He,$t$) and ($t$,$^{3}$He) probes.
description: 14 pages, 10 figures
Hybrid optical and electronic laser locking using spectral hole burning
Creators: name: Farr, Warrick G.
name: Tay, Jian Wei
name: Ledingham, Patrick M.
name: Korystov, Dmitry
name: Longdell, Jevon J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on a narrow linewidth laser diode system that is stabilized using both optical and electronic feedback to a spectral hole in cryogenic Tm:YAG. The laser system exhibits very low phase noise. The spectrum of the beat signal between two lasers, over millisecond timescales, is either Fourier limited or limited by the -111dBc/Hz noise floor. The resulting laser is well suited to quantum optics and sensing applications involving rare earth ion dopants.
description: 4 pages, 3 figures
Chemical composition, in vitro antioxidant, anticholinesterase and antibacterial activities of Linaria scariosa Desf
Creators: name: Ahmed-Chaouch, Meroua
name: Cheriet, Thamere
name: Beretta, Giangiacomo
name: Sarri, Djamel
name: Bensouici, Chawki
name: Ouelbani, Rayene
name: Mancini, Ines
name: Sekhara, Ines
name: Seghiri, Ramdane
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: The study was performed on the dichloromethane (DCM), ethyl acetate (EAc) and n-butanol (Bu) fractions (F) obtained from the 80% ethanol extract of Linaria scariosa Desf. aerial parts, collected in the North Eastern region of Algeria. Remarkable total phenolic and flavonoid contents were obtained, mainly for EAcF. These results were in accordance with the antioxidant activity of EAcF against DPPH, ABTS, CUPRAC and reducing power tests. DCMF and BuF exhibited significant cholinesterase activity inhibition of BChE and AChE. Moreover, EAcF displayed only moderate antibacterial activities, especially against S. aureus. The biological results were correlated to the chemical components, deduced by both GC-MS analysis of the fractions and the isolation of hemipholin, pectolinarigenin, antirride, antirrinoside, pectolinarin and linariosise, some of which known to exhibit potent effects on the tested biological activities. The study provides the first biological and chemical investigation on Linaria scariosa Desf (unresolved name).
Improving the quality of patient care and healthcare staff wellbeing through an empathy immersion educational programme in New Zealand: Protocol of a feasibility and pilot study
Creators: name: Hales, Caroline
name: Deak, Krisztina
name: Popoola, Tosin
name: Harris, Deborah
name: Rook, Mary
Publisher: name: Open Access Victoria University of Wellington | Te Herenga Waka
Year: 2022
Subjects: Uncategorized

description: Empathy is positively related to healthcare workers and patients’ wellbeing. There is, however, limited research on the effects of empathy education delivered in acute clinical settings and its impact on healthcare consumers. This research tests the feasibility and the potential efficacy outcomes of an immersive education programme developed by the research team in collaboration with clinical partners and a multidisciplinary advisory group. Healthcare worker participants in the intervention ward will receive an 8-week immersive empathy education. The primary outcome (feasibility) will be assessed by evaluating the acceptability of the intervention and the estimated resources. The secondary outcome (efficacy) will be assessed using a quasi-experimental study design. Non-parametric tests will be used to test healthcare worker participants’ empathy, burnout, and organisational satisfaction (within-group and across groups), and healthcare consumer participants’ satisfaction (between-group) over time. Despite growing interest in the importance of empathy in professional relationships, to our knowledge, the present pilot study is the first to explore the feasibility and efficacy of an immersive empathy education in New Zealand. Our findings will provide critical evidence to support the development of a randomised cluster trial and potentially provide preliminary evidence for the effectiveness of this type of empathy education.
A framework for securing email entrances and mitigating phishing impersonation attacks
Creators: name: Wosah, Peace Nmachi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Emails are used every day for communication, and many countries and organisations mostly use email for official communications. It is highly valued and recognised for confidential conversations and transactions in day-to-day business. The Often use of this channel and the quality of information it carries attracted cyber attackers to it. There are many existing techniques to mitigate attacks on email, however, the systems are more focused on email content and behaviour and not securing entrances to email boxes, composition, and settings. This work intends to protect users' email composition and settings to prevent attackers from using an account when it gets hacked or hijacked and stop them from setting forwarding on the victim's email account to a different account which automatically stops the user from receiving emails. A secure code is applied to the composition send button to curtail insider impersonation attack. Also, to secure open applications on public and private devices.