cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2: Figure S2. of A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani
Creators: name: P. Vacchina
name: B. Norris-Mullins
name: E. Carlson
name: M. Morales
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Principal components analysis (PCA) of LdWT vs LdR10/LdR30 2D-DIGE. Statistical analysis shows the â  goodâ   clustering of the biological replicates for each experiment: (a) WT vs LdR10 and (b) WT vs LdR30). (PDF 64 kb)
Additional file 5: Figure S5. of Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
Creators: name: Schönherr, Caroline
name: Bien, Jessica
name: Isbert, Simone
name: Rielana Wichert
name: Prox, Johannes
name: Altmeppen, Hermann
name: Sathish Kumar
name: Walter, Jochen
name: Lichtenthaler, Stefan
name: Weggen, Sascha
name: Glatzel, Markus
name: Becker-Pauly, Christoph
name: Pietrzik, Claus
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: APP A673T mutation protects from meprin β mediated cleavage. HEK-293 T cells were transiently transfected with APPwt or APP A673T mutant and co-transfected with the empty vector or meprin β. 24 h post transfection supernatants were immunoprecipitated using Dynabeads conjugated with a 6E10 anti-Aβ antibody, subsequently separated on an 8 M urea gel and probed with 1E8 anti-Aβ1-x/2-x (A). The blot was reprobed with 6E10 anti-Aβ antibody. All samples were run on one gel but rearranged for better presentation. (B) We could exclude a phosphorylation at the substituted threonine that causes a shift of Aβ2-40 by dephosphorylating with λ-phosphatase (New England Biolabs) after the last washing step of the immunoprecipitation. Samples were separated on an 8 M urea gel and probed with 6E10 anti-Aβ antibody that showed no change with or without phosphatase treatment (C). (PDF 936 kb)
Synthesis, Antibacterial, and Antifungal Evaluation of Some New Quinazolinone-Azole Hybrids
Creators: name: Mohammadi, Marzieh
name: Dilmaghani, Karim Akbari
name: Sarveahrabi, Yasin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Nowadays, the need to replace the existing drugs is felt more than ever by increasing drug resistance. Quinazoline is one of the major heterocyclic compounds in biological activity. This research was done to synthesize new derivatives of quinazolin-4(3H)-one and evaluation of their antibacterial and antifungal properties. Ten new quinazolin-4(3H)-one derivatives (5(a–d), 6(a–d), and 7(a,b)) were synthesized by using the nucleophilic substitution reaction of 2-(chloromethyl)-3-(4-chlorophenyl) quinazolin-4(3H)-one (4) and the heterocyclic moieties of 1,3,4-oxadiazole I(a–d) or 1,2,4-triazole (II(a–d), III(a,b)) in the presence of potassium carbonate as base and in acetone as solvent. The chemical structures of the products were approved using 1H-NMR, 13 C-NMR, IR, and Mass spectroscopy. The antimicrobial activity of the compounds was assessed against a panel of Gram-positive and Gram-negative bacteria and species of Candida and Aspergillus fungal. Minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration (MBC/MFC), and inhibition zone (IZ) of these compounds were determined. As results shown, 7a showed better effects against Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa than the other compounds. However, 5d showed better effects against Proteus vulgaris. Compound 6b showed better effects against Candida albicans, Aspergillus fumigatus, and Aspergillus niger, also compound 5a showed better effects against Candida glabrata.
Additional file 11: of Understanding pneumococcal serotype 1 biology through population genomic analysis
Creators: name: Chrispin Chaguza
name: Cornick, Jennifer
name: Harris, Simon
name: Andam, Cheryl
name: Bricio-Moreno, Laura
name: Yang, Marie
name: Feyruz Yalcin
name: Sani Ousmane
name: Shanil Govindpersad
name: Madikay Senghore
name: Chinelo Ebruke
name: Plessis, Mignon Du
name: Anmol Kiran
name: Pluschke, Gerd
name: Betuel Sigauque
name: McGee, Lesley
name: Klugman, Keith
name: Turner, Paul
name: Corander, Jukka
name: Parkhill, Julian
name: Jean-Marc Collard
name: Antonio, Martin
name: Gottberg, Anne Von
name: Heyderman, Robert
name: French, Neil
name: Kadioglu, Aras
name: Hanage, William
name: Everett, Dean
name: Bentley, Stephen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Distribution of genes associated with virulence and colonisation in the ST217 in serotype 1 isolates. Presence of the genes was screened in all the isolates using BLAST as described in the methods section. (PDF 1702Â kb)
Melica uniflora Retz.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Melica
Melica uniflora

description: Melica uniflora Retz.
Artbeschreibung: Unterscheidet sich von M. nutans durch folgende Merkmale: Blatthäutchen höchstens 0,2 mm lang, aber diesem gegenüber ein bis 4 mm langes, spitzes, dem Stängel anliegendes Anhängsel (nur bei dieser M. -Art). Rispenäste schief abstehend, die untersten bis 6 cm lang, mit 1-4 entfernt stehenden Ährchen, unter diesen kahl, Ährchen 5-6 mm lang, +/- aufrecht, mit nur einer fertilen Blüte.
Blütezeit: 5-6(-9)
Standort und Verbreitung in der Schweiz: Laubmischwälder / kollin-montan / J, M, ANW, TI u.a.
Verbreitung global: Europäisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Ffrisch; Feuchtigkeit mässig wechselnd (± 1-2 Stufen)Lichtzahl LschattigSalzzeichen--Reaktionszahl Rsauer (pH 3.5-6.5)Temperaturzahl Tkollin (Laubmischwälder mit Eichen)Nährstoffzahl Nmässig nährstoffarm bis mässig nährstoffreichKontinentalitätszahl Ksubozeanisch (hohe Luftfeuchtigkeit, geringe Temperaturschwankungen, eher milde Winter)
Volksname Deutscher Name: Einblütiges Perlgras Nom français: Mélique uniflore Nome italiano: Melica comune
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Poaceae, pp. 1458-1570 in Flora Helvetica, Bern :Haupt Verlag on page 1556
Investigations into the Shear Strength Reduction method using distinct element models
Creators: name: Fournier, Mathew
Publisher: name: University of British Columbia
Year: 2008

description: This thesis reports a detailed investigation into the use of the Shear Strength Reduction (SSR) method to determine factor of safety values in discontinuum models using the Universal Distinct Element Code. The SSR method depends on the definition of failure within the model and two different criteria were compared: the numerical unbalanced force definition and a more qualitative displacement-monitoring based method. A parametric study was first undertaken, using a simple homogeneous rock slope, with three different joint networks representing common kinematic states. Lessons learned from this study were then applied to a more complex case history used for validation of the SSR method. The discontinuum models allow for the failure surface to propagate based on constitutive models that better idealize the rockmass than simpler methods such as limit equilibrium (e.g. either method of slices or wedge solutions) and even numerical continuum models (e.g. finite difference, finite element). Joints are explicitly modelled and can exert a range of influences on the SSR result. Simple elasto-plastic models are used for both the intact rock and joint properties. Strain-softening models are also discussed with respect to the SSR method. The results presented highlight several important relationships to consider related to both numerical procedures and numerical input parameters. The case history was modelled similar to how a typical forward analysis would be undertaken: i.e. simple models with complexities added incrementally. The results for this case generally depict a rotational failure mode with a reduced factor of safety due to the presence of joints within the rockmass when compared to a traditional limit equilibrium analysis. Some models with large persistence of steeply dipping joints were able to capture the actual failure surface. Softening models were employed in order to mimic the generation and propagation of joints through the rockmass in a continuum; however, only discontinuum models using explicitly defined joints in the model were able to capture the correct failure surface.
Green Beads with Reticella Decoration of the 8th Century BC in Italy – On the Type and Chemical Composition of an Unusual Form
Creators: name: Koch, Leonie C.
name: Yatsuk, Oleh
Publisher: name: Archäologisches Korrespondenzblatt
Year: 2024

description: Green Beads with Reticella Decoration of the 8th Century BC in Italy – On the Type and Chemical Composition of an Unusual Form
Glass beads of the earliest Iron Age in Italy have still not been systematically analysed. Here, two forms are presented, which, according to their common, green glass matrix obtained from copper, combined with a yellow-dark decoration, are unusual for the first half of the 1st millennium BC. They date to the 8th century BC and occur especially in Latium Vetus, but remain seldom. With a parallel on Rhodes, they seem to have been imported from the Aegean, yet, according to their similarity in the combination of trace elements with typical Italian Final Bronze Age beads of the LMHK glass group, a raw glass production and bead manufacture in Italy seem now to be imaginable.
description: Archäologisches Korrespondenzblatt, Bd. 53 Nr. 4 (2023): Archäologisches Korrespondenzblatt
Additional file 3: Figure S3. of A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani
Creators: name: P. Vacchina
name: B. Norris-Mullins
name: E. Carlson
name: M. Morales
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Bioinformatic analysis of L. infantum (LinJ.30.2480). The relationship of L. infantum HSPA9B to other HSPA9B homologs of L. infantum, L. major, T. brucei, T. cruzi, S. cerevisiae, M. musculus and H. sapiens was analyzed by multiple alignment and cluster analysis using Clustal X. Alignment was fed into MEGA 6.0 software and a Neighbor-Joining tree was computed with 500 bootstrap replicates. Numbers on the notes indicate bootstrap support. (PDF 10 kb)
Additional file 3: Figure S3. of Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
Creators: name: Schönherr, Caroline
name: Bien, Jessica
name: Isbert, Simone
name: Rielana Wichert
name: Prox, Johannes
name: Altmeppen, Hermann
name: Sathish Kumar
name: Walter, Jochen
name: Lichtenthaler, Stefan
name: Weggen, Sascha
name: Glatzel, Markus
name: Becker-Pauly, Christoph
name: Pietrzik, Claus
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: APP and meprin β colocalize in the secretory pathway and at the cell surface. HEK cells were co-transfected with APP-GFP and meprin β-dsRed. Both proteins predominantly colocalize in the cis-golgi compartment. Colocalization in early endosomes was hardly detectable. (PDF 890 kb)
Additional file 5: Table S1. of A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani
Creators: name: P. Vacchina
name: B. Norris-Mullins
name: E. Carlson
name: M. Morales
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Ecology
subject: Developmental Biology
subject: Hematology

description: Cross-resistance to reference compounds. HSPA9B-mCherry overexpressing lines are significantly more resistant to amphotericin B, antimony (III) and pentamidine isethionate when compared to WT cultures. All the cultures were analyzed in triplicate and data is indicated as meanâ  Âąâ  SD of three independent experiments. (PDF 40 kb)
Synthesis, Quantum Mechanical Studies, Physicochemical Properties and Molecular Docking Studies of Schiff Base N-N-(1,2-Phenylene)Bis(1-(4-Bromophenyl)Methanimine) from o- Phenylenediamine and 4-Bromobenzaldehyde
Creators: name: Ganesan, T. Sankar
name: Elangovan, N.
name: Sirajunnisa, A.
name: Angel, T.
name: Sowrirajan, S.
name: Chandrasekar, S.
name: Nair, Deepthi S. Rajendran
name: Thomas, Renjith
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Computational Biology

description: Schiff bases have advanced physical, chemical, and medicinal properties, making them strong biological agents. Comparable FTIR, UV-VIS, 1HNMR, 13CNMR spectra confirmed the successful formation of N-N-(1,2-Phenylene)bis(1-(4-bromophenyl)methanimine) (CS3) compound. Geometry was optimized using DFT with B3LYP/cc-pVDZ basis set. Obtained energy gap of the compound was 2.07 eV. Carbon and oxygen atoms were electrophilic, according to molecular electrostatic potential analysis. Mulliken charge analysis found that C atoms have + ve and -ve charges, H atoms have only positive charges, while Br, O, and N atoms have only -ve charges. The ELF analyzed the molecule and found that the atoms of C, N, and Br all had delocalized electron density. The wave function LOL identified localized orbital positions in the hydrogen atoms. RDG maps provided various non-covalent interactions. Synthesized compound was docked using PDB: 2ZM5 protein, with the lowest binding attractions obtained, are −5.44 (7BYE) kcal/mol.
Combinatorial Effect of Syringic Acid-Pyrazinamide Adduct against Luminal Type Breast Cancer Investigated through DFT, Drug-Likeness, and Molecular Docking Simulation
Creators: name: Priya, Mohana
name: Zochedh, Azar
name: Palaniyandi, Karthikeyan
name: Shunmuganarayanan, Athimoolam
name: Sultan, Asath Bahadur
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Luminal type breast cancer is a type of breast cancer that has a favorable prognosis in comparison to other forms. In accordance with the proliferation index, luminal-type breast malignancy is divided as luminal A and B types. The combination of two molecules will be a more effective strategy for the treatment of breast cancer. In this study, the structural and different spectroscopic parameters for the 4-hydroxy3, 5-dimethoxybenzoic acid-pyrazine 2-carboxamide cocrystal were calculated using quantum mechanics employing the B3LYP/6–311++G (d,p) approach. With the use of XRD data, the optimized geometrical parameters were compared. The HOMO-LUMO, molecule electrostatic potential surfaces, and vibrational investigations of the cocrystal are all computed. The possibility of charge transmission inside the particle is demonstrated by the minimal HOMO–LUMO energy gap. The existence of intermolecular OH…O hydrogen bonds, which are brought about by the interface of the oxygen lone pair with the anti-bonding orbital, was demonstrated by NBO examination. The drug-likeness possessions exhibited the safety profile of the 4-hydroxy-3,5-dimethoxybenzoic acid-pyrazine-2-carboxamide adduct. The results of molecular docking indicate that the cocrystal of 4-hydroxy3, 5-dimethoxybenzoic acid and pyrazine 2-carboxamide revealed better binding ability against luminal type breast cancer proteins with docking values of −8.3, −7.6, and −8.7 kcal/mol.
Additional file 10: of Understanding pneumococcal serotype 1 biology through population genomic analysis
Creators: name: Chrispin Chaguza
name: Cornick, Jennifer
name: Harris, Simon
name: Andam, Cheryl
name: Bricio-Moreno, Laura
name: Yang, Marie
name: Feyruz Yalcin
name: Sani Ousmane
name: Shanil Govindpersad
name: Madikay Senghore
name: Chinelo Ebruke
name: Plessis, Mignon Du
name: Anmol Kiran
name: Pluschke, Gerd
name: Betuel Sigauque
name: McGee, Lesley
name: Klugman, Keith
name: Turner, Paul
name: Corander, Jukka
name: Parkhill, Julian
name: Jean-Marc Collard
name: Antonio, Martin
name: Gottberg, Anne Von
name: Heyderman, Robert
name: French, Neil
name: Kadioglu, Aras
name: Hanage, William
name: Everett, Dean
name: Bentley, Stephen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Intragenic number of observed and expected numbers of SNPs in the ST217 isolates. All the genes in the ST217 isolates, sizes, observed (OSNP) and expected (ESNP) number of SNPs, ratio OSNP to ESNP and products of each gene are summarised. (DOCX 315Â kb)
Additional file 1: of Cytosolic phospholipase A2 (cPLA2) IVA as a potential signature molecule in cigarette smoke condensate induced pathologies in alveolar epithelial lineages
Creators: name: Subodh Yadav
name: Sharma, Sanjeev
name: Farooque, Abdullah
name: Gaurav Kaushik
name: Kaur, Balwinder
name: Pathak, Chander
name: Bilikere Dwarakanath
name: Khanduja, Krishan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary data. Table S1. Primer Sequences of various genes. Table S2. CSC-induced mRNA expression of various cPLA2 groups in A-549 and WI-26 Cells. The values (mean ± SD of three different experiments) are in folds of control values. Figure S1. Schematic presentation of proposed plan of experimental design. Figure S2. Effect of CSC treatment at concentrations’ of 150 μg/ml (b) and 200 μg/ml (c) on cell morphology in lung epithelial type II (A-549) cells and type I (WI-26) cells. Figure 2a shows the normal morphology in two types of the cells (Magnification 5x). (DOCX 1098 kb)
Additional file 6: Figure S5. of A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani
Creators: name: P. Vacchina
name: B. Norris-Mullins
name: E. Carlson
name: M. Morales
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Science Policy
subject: Plant Biology

description: Principal components analysis (PCA) of WT vs HSPA9B-mCherry 2D-DIGE. Statistical analysis shows the â  goodâ   clustering of the biological replicates for each sample. (PDF 41 kb)
Additional file 5: of Understanding pneumococcal serotype 1 biology through population genomic analysis
Creators: name: Chrispin Chaguza
name: Cornick, Jennifer
name: Harris, Simon
name: Andam, Cheryl
name: Bricio-Moreno, Laura
name: Yang, Marie
name: Feyruz Yalcin
name: Sani Ousmane
name: Shanil Govindpersad
name: Madikay Senghore
name: Chinelo Ebruke
name: Plessis, Mignon Du
name: Anmol Kiran
name: Pluschke, Gerd
name: Betuel Sigauque
name: McGee, Lesley
name: Klugman, Keith
name: Turner, Paul
name: Corander, Jukka
name: Parkhill, Julian
name: Jean-Marc Collard
name: Antonio, Martin
name: Gottberg, Anne Von
name: Heyderman, Robert
name: French, Neil
name: Kadioglu, Aras
name: Hanage, William
name: Everett, Dean
name: Bentley, Stephen
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Recombination events identified in the West African clade (SC2-WA). (a) Maximum likelihood phylogeny showing genetic relationship of the isolates in the SC. Color strips labeled (b) and (c) shows country and continent of origin of the isolates respectively. (d) Annotations in the reference serotype 1 genome. (e) Horizontal tracks from the phylogenetic tips represent each genome. The coloured blocks shows locations of the recombination events in the chromosome. Red blocks show shared recombination events identified in at least two isolate while the blue blocks show strain specific (unique) recombination events. (PDF 1452Â kb)
title: Dynamiques des diasporas littéraires
Publisher: name: CRILLASH
Year: 2024

description: Collection dédiée à la dynamique des échanges diasporiques des espaces littéraires des Amériques, de l'Afrique et de l'Asie. Les contributions proviennent, pour la plupart, de rencontres universitaires co-organisées ou coproduites avec d'autres structures ou institutions liées à la recherche, la création artistique ou littéraire.
Antibacterial Potential of Trihydroxycyclohexa-2,4-Diene-1-Carboxylic Acid: Insight from DFT, Molecular Docking, and Molecular Dynamic Simulation
Creators: name: Owen, Aniekan E.
name: Chima, Chioma M.
name: Ahmad, Iqrar
name: Emori, Wilfred
name: Agwamba, Ernest C.
name: Cheng, Chun-Ru
name: Benjamin, Innocent
name: Patel, Harun
name: Ahuekwe, Eze F.
name: Ojong, Mmefone A.
name: Ubah, Chioma B.
name: Manicum, Amanda-Lee E.
name: Louis, Hitler
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: In this study, (z)-5-((3-(2,3-dihydroxyphenyl) acryloyl) oxy)- 1,3,4-trihydroxycyclohexa-2,4-diene-1-carboxylic acid (chlorogenic acid) was isolated and characterized using UV-Visible, 1H NMR and 13C NMR, FT-IR, along with detailed investigation using density functional theory (DFT), in-silico molecular docking, and molecular dynamics (MD) simulation. Results from DFT calculation indicates that the titled compound is very stable with energy gap of 3.7–7.8 for variable functionals, and similarly, the structural parameters show very close agreement with X-ray data for bond lengths and angles. The FT-IR spectrum results revealed stretching vibration O–H (3366 cm−1), C=O (1689 cm−1), C–H (1636, 1606, 1522, and 1442 cm−1), C–O (1192 and 1122 cm−1). The drug-likeness analyses and ADME studies showed drug-likeness ability and good oral behavior of the investigated compound as it obeys Lipinski, Ghose, Veber and Egan rules. Hepatotoxic and immunotoxic activities were indicated for the toxicity/toxicological endpoints of the studied compound. The molecular docking indicates a binding affinity of −8.30 and 9.5 kcal/mol for the titled compound, which is higher than the standard drug. From the molecular dynamic simulation results, chlorogenic-2H14 (complex B) revealed variations in RMSD values of less than 3Å, indicating that the protein structure underwent minor conformational changes throughout the simulation. Chlorogenic-protein complexes had average RGyr values of 3.704 − 4.907Å, which indicates compaction during the simulation. Therefore, it can be said that the titled compound has potential to be effective as an agent for cholera management, and the results obtained can be platform further in-vitro, vivo and clinical trials.
MOESM2 of Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells
Creators: name: Kutmon, Martina
name: Coort, Susan
name: Nooijer, Kim
name: Lemmens, Claire
name: Evelo, Chris
Publisher: name: Figshare
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 60506 Virology

description: Supplementary material 2 (PDF 2486Â kb)
Steinweidband in Muotathal (Ct. Schwyz / CH): A Mesolithic Hunting Camp in a Subalpine Settlement Landscape
Creators: name: Leuzinger, Urs
name: Affolter, Jehanne
name: Beeler, Peter
name: Haas, Jean Nicolas
name: Hajdas, Irka
name: Imhof, Walter
name: Jagher, Reto
name: Müller, Werner
name: Ruchti, Eva-Maria
name: Schoch, Werner H.
name: Steiner, Michael A.
name: Thew, Nigel
Publisher: name: Archäologisches Korrespondenzblatt
Year: 2024

description: The Steinweidband in Muotathal (Ct. Schwyz / CH): A Mesolithic Hunting Camp in a Subalpine Settlement Landscape
Archaeological surveys and excavations from 2005 to 2023 in the municipality of Muotathal have so far revealed nine Mesolithic sites with radiocarbon-dated charcoal and faunal remains, as well as typologically identifiable silices. The differing topographical situations of the sites and find assemblages make it possible to propose a modelled reconstruction of land usage by Mesolithic hunter-gatherer groups in the mountainous Alpine study area. Base camps, campsites at passages obligés and hunting observation posts visited in summer or autumn can be identified. In winter, groups of people probably remained on the Swiss Plateau. Determination of siliceous raw materials provides evidence of contacts and exchange systems involving the Central Plateau, the Jura, the Alpine Rhine Valley and southern Alpine regions. Palaeoethnobotanical, osteological, anthracological and malacological investigations additionally provide valuable data regarding the climate, environment and anthropogenic supply strategies.
description: Archäologisches Korrespondenzblatt, Bd. 53 Nr. 4 (2023): Archäologisches Korrespondenzblatt
Heroldishausen (Unstrut-Hainich-Kreis) – Teil einer älterwartbergzeitlichen Siedlungskammer im westlichen Thüringer Becken
Creators: name: Schwarck, Nadine
name: Hoffmann, Robert
name: Rinne, Christoph
Publisher: name: Archäologisches Korrespondenzblatt
Year: 2024

description: Heroldishausen (Unstrut-Hainich-Kreis) – Teil einer älterwartbergzeitlichen Siedlungskammer im westlichen Thüringer Becken
Der Fundplatz von Heroldishausen-»Schere« ist seit langem als Siedlung mit einem umfangreichen keramischen Inventar innerhalb einer thüringischen Siedlungskammer der spätneolithischen Wartberg-Gruppe bekannt. Das Fundmaterial zeigt Bezüge zu Inventaren des Harzvorlandes, die einem älteren Abschnitt deutlich vor 3000 v. Chr. zugewiesen werden. Die hier vorgestellten Radiokarbondatierungen belegen erstmals eine absolutchronologische Datierung in die Zeit zwischen 3450 und 3000 v. Chr. Auf der Grundlage der auch in Heroldishausen belegten Gefäßzier der Lochbuckel werden hier neue Überlegungen zum Zeitraum und vor allem zum räumlichen sowie kulturellen Kontext der Entstehung von Wartberg entwickelt.
description: Archäologisches Korrespondenzblatt, Bd. 53 Nr. 4 (2023): Archäologisches Korrespondenzblatt
Micropyrum tenellum Link
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Micropyrum
Micropyrum tenellum

description: Micropyrum tenellum (L.) Link
Artbeschreibung: 15-40 cm hoch, büschelig, im Habitus wie ein zierliches Lolium. Blätter kurz, borstenförmig. Blatthäutchen höchstens 0,5 mm lang, zerschlitzt, mit 2 aufwärts gerichteten Zipfeln. Blütenstand eine 2-10 cm lange, schlanke, ährenartige und 2zeilige Traube mit 2kantiger Hauptachse. Ährchen 5-10 mm lang, mit kurzen, dicken Stielen, mit der Breitseite dem Stängel zugekehrt. Beide Hüllspelzen 3nervig und +/- gleich lang. Deckspelzen stumpf, ohne Grannen, nicht gekielt.
Blütezeit: 5-7
Standort und Verbreitung in der Schweiz: Steinige und sandige Böden / kollin / TI, GE
Verbreitung global: Mediterran
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Kies-Dünnschwingel Nom français: Fétuque délicate Nome italiano: Festuca annuale
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Poaceae, pp. 1458-1570 in Flora Helvetica, Bern :Haupt Verlag on page 1556
Experimental Raman, FTIR and UV-Vis Spectra, DFT Studies of Molecular Structures and Conformations, Barrier Heights Against Internal Rotations, Thermodynamic Functions and Bioactivity of Biologically Active Compound - Isorhamnetin
Creators: name: Yadav, Bhoopendra
name: Yadav, Rohit Kumar
name: Srivastav, Gaurav
name: Yadav, R. A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Molecular structural, conformational and spectroscopic investigations on the isorhamnetin molecule have been carried out at the B3LYP/6-311++G(d,p) level. Experimental FTIR, Raman and UV–vis spectra have been recorded and analyzed in light of the computed quantities and potential energy distributions (PEDs). In addition, MEP, Iso-surface plot of ESP and HOMO-LUMO energies, the barrier heights for the internal rotations about different axes and different thermodynamic functions were computed. Moreover, the wavefunction properties like reduced density gradient and electron localization function were computed. To investigate the biological properties, the bioactivity scores were computed and the molecular docking was also performed. The planarity of the flavone skeleton was stabilized by intramolecular interactions of O16.H24, and O26…H22. The barrier heights for bound OH tops were three times than the free OH tops. The bond length of the C-C linkage was found to be the longest among all the C-C bonds. Out of 99 normal modes, only 66 normal modes were seen to be conformer dependent. The sites near the H and O-atoms of free OH groups are more effective for nucleophilic and electrophilic attacks. The HOMO-LUMO analysis suggests that the molecule is chemically soft. From the observed UV-Vis spectral analysis bathochromic shift was noticed. Thermodynamic functions varied non-linearly with temperature. The bioactivity scores and molecular docking suggest that the molecule is a bioactive molecule. The results of the present investigations made on the isorhamnetin molecule are reported for the first time.
Improved teleseismic Green's functions and western Canada mantle structure and evolution
Creators: name: Mercier, Jean-Philippe
Publisher: name: University of British Columbia
Year: 2008

description: The present thesis is divided into three distinct parts and focuses both on the improvement of deconvolution technique in a teleseismic context for crustal and upper-mantle studies and on the understanding of western Canada structure and evolution through seismic imaging. The first part presents estimates of the P-component of the teleseismic-P Green's functions for three stations of the Canadian National Seismic Network (CNSN) obtained using a new deconvolution technique. Our results show evidence of the principal, first-order scattered Moho phases and, in particular, the Pp_Mp. The second part presents teleseismic receiver functions from 20 broadband three-component seismometers deployed along the MacKenzie-Liard Highway in Canada's Northwest Territories as part of the joint Lithoprobe-IRIS CAnadian NOrthwest Experiment (CANOE). These stations traverse a Paleoproterozoic suture and subduction zone that has been previously documented in detail to mantle depths using seismic reflection profiling. Our results reveal the response of the ~1.8 Ga subduction zone on both the radial and transverse component. The identification of this structure and its comparison with fine-scale mantle layering below the adjacent Slave province and from a range of Precambrian terranes provides an unambiguous connection between fossil subduction and fine-scale, anisotropic mantle layering found beneath cratons. Previous documentation of similar layering below the adjacent Slave province provides strong support for the thesis that early cratonic blocks were stabilized through processes of shallow subduction. The last part presents P- and S wave velocity models for western Canada. In this part, we focus our attention on two distinct features: 1) the transition from Phanerozoic to cratonic mantle in northwestern Canada and 2) the complex tectonic environment at the northern terminus of the Cascadia subduction zone where the plate boundary changes from convergent to transform. We find that the main transition from Phanerozoic to cratonic mantle in northwestern Canada occurs at the Cordilleran deformation front. In northern Cascadia, we have imaged and characterized the signature of the subducting Juan de Fuca plate and observed evidence of subduction beyond the northern edge of the slab. Our result show that the Anahim hotspot track is underlain by a -2% low-velocity zone.
Tackling growing inequalities (UNTANGLED Policy Brief)
Creators: name: Capello Roberta
name: Lenzi Camilla
name: Panzera Elisa
name: Caragliu Andrea
Publisher: name: Zenodo
Year: 2024

description: Growing inequalities are shaping modern economies and societies, driven by dramatic changes in the technological landscape, in the organisation of global transactions and value chains and in response to global challenges raised by the financial crisis, the pandemic and the energy crisis. The emerging inequalities are manifest in diverging trends in economic and employment growth between places, as well as the redistribution of wealth among population and worker groups (Chancel et al., 2022). Increasing inequalities are therefore a dominant trait of the contemporary era. Even if national tax and benefits systems can partly mitigate the effects of automation on income inequality (Doorley et al., 2023), digitalisation is expected to amplify inequalities across places (Capello et al., 2023), across firms (Jona-Lasinio and Venturini, 2022) and workers (Perugini and Pompei, 2022).In the opinion of many commentators and scholars, this scenario calls for attention to possible policy actions to curb such multiple inequalities or at least to mitigate their most harmful effects. By analysing some of the factors pushing toward the upsurge of inequalities in the new millennium, Project UNTANGLED has contributed to understanding of which policy fields such interventions could target and the potential complementarities and synergies among EU, national and regional-level actions.Such multi-dimensional and multi-level policies may range from the creation and/or upgrading of digital infrastructure and uptake of cutting-edge technologies, to a renewed prominence of all those social policies aimed at upskilling the current and future labour force and to ensure quality jobs, all central themes in the EU Digital decade agenda.
MATNLARNI IZLASHDA KENGAYTIRILGAN MANTIQIY USULDAN FOYDALANISH
Creators: name: Maxmudov Z.M. dotsent
Publisher: name: Zenodo
Year: 2024

description: Ko’p yillar davomida insonlar ma'lumotni arxivlash va qidirish muhimligini anglab yetdi. Kompyuterlarga bo'lgan ehtiyoj tufayli bunday huhhatlar to'plamlardan foydali ma'lumotlarni topish zaruratga aylandi. Axborot qidirish kompyuter fanlari sohasidagi muhim tadqiqot sohasiga aylandi va biznes, sog'liqni saqlash, qishloq xo'jaligi, tibbiyot, huquq va boshqa ko'plab sohalarda bir qancha sohalarda ahamiyat kasb etdi. Ushbu tadqiqot mavzusi ma'lumotni izlab topish bilan bog'liq ehtiyojlar, modellar va jarayonlarga qaratilgan.

Kalit so'zlar - Axborot qidirish, AQ (IR) modellari, jarayonlar
MOESM3 of Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells
Creators: name: Kutmon, Martina
name: Coort, Susan
name: Nooijer, Kim
name: Lemmens, Claire
name: Evelo, Chris
Publisher: name: Figshare
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 60506 Virology

description: Supplementary material 3 (PDF 672Â kb)
Milium effusum L.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Poales
Poaceae
Milium
Milium effusum

description: Milium effusum L.
Artbeschreibung: 50-120 cm hoch, kahl. Blätter bis 15 mm breit, allmählich zugespitzt, rau. Blatthäutchen ca. 5 mm lang, breit gerundet, meist zerschlitzt. Blütenstand eine sehr lockere, 10-25 cm lange Rispe mit dünnen, welligen, nur wenige Ährchen tragenden, nach dem Blühen +/- waagrecht abstehenden, zuletzt zurückgeschlagenen Ästen. Ährchen 2,5-3 mm lang, einblütig, mit 2 gleichen, die Blüte einschliessenden, stumpfen Hüllspelzen. Keine Grannen.
Blütezeit: 5-6
Standort und Verbreitung in der Schweiz: Wälder, Hochstaudenfluren / kollin-subalpin / CH
Verbreitung global: Eurasiatisch-nordamerikanisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fmässig feuchtLichtzahl LschattigSalzzeichen--Reaktionszahl Rsauer (pH 3.5-6.5)Temperaturzahl Tunter-montan und ober-kollinNährstoffzahl Nmässig nährstoffarm bis mässig nährstoffreichKontinentalitätszahl Ksubozeanisch (hohe Luftfeuchtigkeit, geringe Temperaturschwankungen, eher milde Winter)
Volksname Deutscher Name: Waldhirse, Flattergras Nom français: Millet étalé Nome italiano: Miglio selvatico
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Poaceae, pp. 1458-1570 in Flora Helvetica, Bern :Haupt Verlag on page 1556
MOESM4 of Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells
Creators: name: Kutmon, Martina
name: Coort, Susan
name: Nooijer, Kim
name: Lemmens, Claire
name: Evelo, Chris
Publisher: name: Figshare
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 60506 Virology

description: Supplementary material 4 (PDF 724Â kb)
ADDENDUM: Matching of Extradyadic Stress and Sexual Activity – A Dyadic Response Surface Analysis
Creators: name: Bodenmann, Guy
name: Roth, Michelle
name: Landolt, Selina Andrea
name: Impett, Emily
name: Weitkamp, Katharina
Publisher: name: OSF Registries
Year: 2022
Subjects: subject: Clinical Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: couples
subject: dyadic response surface analysis
subject: romantic relationships
subject: sexual activity
subject: sexuality
subject: stress

description: This study aims to examine how extradyadic stress (stress that originates outside of the couple relationship) is linked to sexual activity in couples. With Dyadic Response Surface Analysis (DRSA; Schönbrodt et al., 2018) and a dataset of 368 mixed-gender couples, we aim to: (1) replicate the previously documented negative association between one person’s extradyadic stress and their own sexual activity (Bodenmann et al., 2010) in a dyadic sample and (2) explore if (mis)matching of extradyadic stress among partners can diminish the couple's sexual activity. In the case of matching, both partners experience similar stress levels, whereas, in mismatching, one partner experiences higher stress levels than the other. Further, in case of mismatching, we aim to (3) test whether men’s or women’s extradyadic stress is more influential on the couple's sexual activity, as some studies indicate that men and women might differ in the impact of their experienced stress on their sexuality (Bodenmann et al., 2007). In this addendum, we are preregistering an additional set of analyses to those outlined in our original preregistration.
Seismic ground-roll separation using sparsity promoting L1 minimization
Creators: name: Yarham, Carson Edward
Publisher: name: University of British Columbia
Year: 2008

description: The removal of coherent noise generated by surface waves in land based seismic is a prerequisite to imaging the subsurface. These surface waves, termed as ground roll, overlay important reflector information in both the t-x and f-k domains. Standard techniques of ground roll removal commonly alter reflector information as a consequence of the ground roll removal. We propose the combined use of the curvelet domain as a sparsifying basis in which to perform signal separation techniques that can preserve reflector information while increasing ground roll removal. We examine two signal separation techniques, a block-coordinate relaxation method and a Bayesian separation method. The derivations and background for both methods are presented and the parameter sensitivity is examined. Both methods are shown to be effective in certain situations regarding synthetic data and erroneous surface wave predictions. The block-coordinate relaxation method is shown to have major weaknesses when dealing with seismic signal separation in the presence of noise and with the production of artifacts and reflector degradation. The Bayesian separation method is shown to improve overall separation for both seismic and real data. The Bayesian separation scheme is used on a real data set with a surface wave prediction containing reflector information. It is shown to improve the signal separation by recovering reflector information while improving the surface wave removal. The abstract contains a separate real data example where both the block-coordinate relaxation method and the Bayesian separation method are compared.
MOESM2 of Description of Campylobacter jejuni Bf, an atypical aero-tolerant strain
Creators: name: Ramila Rodrigues
name: Anne-Lise Pocheron
name: Hernould, Mathieu
name: Haddad, Nabila
name: Tresse, Odile
name: Jean-Michel Cappelier
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Growth and survival of C. jejuni NCTC and Bf in AC at 42Â°C in BHI broth.
AI for automation of contouring in brachytherapy
Creators: name: Maspero, Matteo
Publisher: name: Zenodo
Year: 2024
Subjects: radiotherapy
medical imaging
segmentation
image synthesis
artificial intelligence
deep learning
machine learning

description: List of commercial solutions for automatic segmentation and generation of synthetic CT (pseudo-CT) in radiotherapy along with talks.

Initially made for www.DLinRT.org educational sessions, and partially presented also under the title "Artificial intelligence (deep learning) for image synthesis" at the session "AI for (online?) IGRT" held on Sunday May 14, 15:15 - 16:30, Strauss 1 at ESTRO2023, along with an "Overview of deep learning-based products in radiotherapy: segmentation and synthetic CT".Updated in May 2024 for the session "What's new in AI developments and automation for brachytherapy" and the talk titled "AI for automation of contouring in brachytherapy" on Sunday May 4, 14:45-16:00 at ESTRO2024.

Versioning

Version 2.0/2.1 (typo corrected) presentation at ESTRO 2024, Glasgow, 3-7 May 2024 on 05-05-2024 + overview DL-based clinical products 

Version 1.1 overview product, released for DLinRT 2024 education session, Utrecht, on 24-01-2024.

Version 0.1 presentation + 1.0 overview product, released for ESTRO 2023, Vienna, 11-16 May 2023 on 13-05-2023.