cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Doing time on the outside: Managing relationships with imprisoned men
Creators: name: McCuaig, Erin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Sociology, Criminology and Penology.
subject: Sociology, Individual and Family Studies.

description: Traditionally criminological inquiry has excluded the voices of female partners of imprisoned men, leaving their lived experiences and impacts of incarceration unacknowledged. This is a disturbing oversight in light of the stigmatization of this group both by the correctional system and in society. This thesis is an exploratory study that seeks to capture some of the experiences and challenges faced by female partners of male prisoners to shed light on their lived realities. In order to do so, this study has built upon symbolic interactionism, by drawing on Goffman's concept of stigma, the more recent theorizing around this concept as well as the issue of resistance. This theoretical framework has provided a useful lens through which to examine how structural stigma and interpersonal stigma are experienced by female partners of prisoners. The research is a qualitative study. Five female partners of male prisoners were interviewed regarding their experiences, challenges, and negotiations in the correctional and social spheres. The findings were analyzed and ultimately broken down into four sections: the challenges experienced in corrections and in the social realm, the hardships of intimate relations related to incarceration and the positive side to enforced separation. The analysis revealed that the experiences and coping strategies of women partners of prisoners are diverse. Further, structural stigma and interpersonal stigma (in particular the use of search technologies) were significantly present. In response to these challenges the study highlights that the women engaged in numerous tactics of overt and covert resistance. The findings, while recognizing the agency of these women also speaks to the imperative need for Corrections to humanize their policies and practices.
Belousov-Zhabotinsky Oscillators in Polydimethylsiloxane Microfluidic Devices
Creators: name: Sheehy, James V
Publisher: name: Brandeis University
Year: 2021
Subjects: subject: Central Pattern Generators
subject: Chemical Oscillators
subject: Coupling
subject: Polydimethylsiloxane
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Microfluidics
subject: Neurons

description: The synchronization of oscillators in a network proves a powerful tool for establishing systems which perform complex tasks with relative ease. From the synchronization of fireflies to the coordinated action of neurons embedded in muscle, oscillator dynamics drives a number of natural phenomena. The framework of network synchronization for individual actors proves robust and flexible, allowing for the interactions of microscopic units to have macroscopic impacts. These properties are ideal for the fabrication of novel materials. The Belousov-Zhabotinksy (BZ) reaction is a light sensitive oscillatory chemical mixture which can be confined within a polydimethylsiloxane (PDMS) microfluidic device. In confinement, the BZ acts as a single oscillator, but through the diffusive coupling of the chemical communicator bromine, isolated BZ oscillators can interact. To develop networks capable of supporting larger scales of network synchronization, we begin by understanding the interactions of the BZ with its PDMS substrate. In this work, we a single BZ oscillator and pairs of coupled BZ oscillators in PDMS. We discover that there is a significant interaction between the PDMS and the BZ, which increases the heterogeneity of the oscillators' behavior and even causes wells to stop oscillating in extreme cases. This interaction between PDMS and BZ can be mitigated through the use of a controlled chemical boundary. By studying the interaction of the BZ oscillator with PDMS and light, we are able to establish control over the behavior of a single BZ oscillator, allowing us to change the frequency of the oscillations by up to 15% and the phase of an individual oscillator by up to 30% of the oscillator period. Transitioning to a pair of BZ oscillators, we are able to establish control over the interaction between BZ oscillators, allowing us to control the synchronization time for the oscillators, as well as the final state to which the oscillators synchronize. Through the work laid out in this thesis we aim to lay the ground work for future systems to establish control over larger and more complex networks of oscillators.
Mechanistic Dissection of Bud14 regulation of Yeast Cell Morphology
Creators: name: Brody, Stephanie
Publisher: name: Brandeis University
Year: 2023
Subjects: Cell polarization
BUD14

description: Cell polarization allows cells to orient their growth and movement and is integral to cell and tissue morphogenesis in diverse biological contexts. A well characterized model of cell polarization is the budding yeast Saccharomyces cerevisiae. These single-celled fungi undergo polarized growth, which requires directed delivery of biosynthetic components and organelles from the mother cell to the growing daughter cell, or bud. For more than 20-years we have known that a polarized actin cable network directs secretion to allow polarized growth in budding yeast, and yet many of the crucial details of the underlying mechanism behind formation of this polarized actin network have remained unclear. In my thesis work, I have addressed this question and uncovered new functions for the yeast-specific protein, Bud14, in directing polarized cell growth. Bud14 was previously identified as a regulatory subunit of the yeast Protein Phosphatase 1 (PP1/Glc7), and then as a binding partner of Bnr1, one of the two yeast formins (a family of actin-assembly proteins) that assemble the actin cable network. I have used CRISPR/Cas9 to introduce targeted mutations in the BUD14 coding sequence to specifically disrupt sequences involved in its direct interactions with the formin Bnr1 and the phosphatase Glc7. Using this approach, I have found that Bud14-Glc7 interactions are required for regulating cell morphology, whereas Bud14-Bnr1 interactions are not. Furthermore, I identify a new role for Bud14 in controlling the localization and dynamics of the second yeast formin, Bni1, and show that there is a correlation between hyperaccumulation of Bni1 at the cell tip and an elongated cell morphology.
Cardiotrophin-1 as an ex vivo activator of a stem-cell like population in the murine heart
Creators: name: Knudson, Jennifer Caroline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.
subject: Biology, Animal Physiology.

description: The identification of a multi-potent stem cell-like population (SP) within the adult murine heart infers new methods of cardiac repair, i.e. stem cells compensate for damage by generating new cardiomyocytes. Several studies have emphasized the dominance of the tissue microenvironment on the differentiation & functional properties of stem cells. Of particular interest was Cardiotrophin-1 (CT-1), a member of the Interleukin-6 (IL-6) family of cytokines. To assess whether CT-1 functioned as an activator of cardiac SP cells in the murine heart, an adenovirus containing the full length CT-1 driven by a ubiquitous promoter was generated. The adenovirus was administered via intra-cardiac injections and the effects of CT-1 were primarily assessed using fluorescence-activated cell sorting (FACS) analysis. Analysis showed a temporary increase in the cardiac SP of CT-1 injected hearts. A closer look at the SP cells in other tissues (liver, skeletal muscle and bone marrow) demonstrated that this phenomenon was cardiac specific. Interestingly the cardiac SP expressed the Leukemia Inhibitory Factor (LIF) receptor, which is required for CT-1 signaling through the 130 pathway. Protein analysis also showed that STAT3, a downstream member of the 130 pathway becomes activated in the heart during CT-1 injections. Preliminary results from co-culture experiments suggested that this increase was also accompanied by SP cell differentiation. These results proposed that CT-1 not only increased the cardiac SP size but may have also activated a cardiac differentiation program. The existence of a potential biologic stimulant (CT-1) for cardiac stem cells is an exciting prospect and offers support to the notion that cardiac repair may become a viable therapeutic option in the not too distant future.
La scienza è aperta: fare ricerca e condividerla in tempi di crisi
Creators: name: Giglia, Elena
Publisher: name: Zenodo
Year: 2020
Subjects: Open Science, scholarly communication, FAIR data, data management, DMP

description: Webinar EBSCO 5 giugno 2020 La pandemia Coronovirus ha messo in evidenza la crisi del modello attuale di comunicazione scientifica. Condividere i dati e i testi è fondamentale per far progredire la scienza più rapidamente. Durante il webinar abbiamo presentato l'alternativa Open, che può contribuire a riportare la scienza al suo valore originario di grande conversazione. Registrazione del webinar: https://ebsco.webex.com/recordingservice/sites/ebsco/recording/play/241eadf9d02c4a5fbbabf03d817fbce7
A novel marking-based detection and filtering scheme against distributed denial of service attack
Creators: name: Chen, Yao
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: The Denial of Service (DoS) attack, including Distributed Denial of Service (DDoS) Attack, has become one of the major threats to the Internet today. The victim's resources are exhausted so that its services are disrupted under the DoS attack. Spoofed packets, in which the source IP addresses are forged, are usually used by attackers to implement the attacks or disguise their actual locations. In this thesis, we investigate DoS attack, analyze some existing defense mechanisms, and compare their strengths and weaknesses. Then, we present a novel Marking-based DDoS Attack Detection and Filtering (MDADF) scheme. The MDADF system can distinguish and filter out spoofed IP packets by maintaining a record of the legitimate users and their markings. The system also functions as a DDoS attack detector. We evaluate the performance of this under various conditions in a simulated environment. The results demonstrate that the system is effective in defending against massive DDoS attacks, even when only 20% of the routers on the Internet participate in the marking process. The system is specially effective against IP-spoofed attacks, which are the most difficult to control, although it works well even under randomized attacks. Moreover, the system detects the occurrence of an attack quite quickly and precisely.
Sleep Quality but Not Sleep Quantity Effects on Cortisol Responses to Acute Psychosocial Stress
Creators: name: Bassett, Sarah M.
Publisher: name: Brandeis University
Year: 2014
Subjects: cortisol
psychosocial stress
sleep habits
sleep quality
sleep quantity
Trier Social Stress Test

description: Objective: Poor sleep is a widespread problem and given the well-documented deleterious health effects, has become a serious public health concern. As such, increasing efforts are directed towards understanding the underlying mechanisms. One potential mechanism may be cortisol dysfunctions, however, studies investigating the effects of poor sleep on a body’s capacity to deal with challenges are lacking. The current study thus aimed at testing the effects of sleep quality and sleep quantity on cortisol responses to acute psychosocial stress.\r Methods: N=73 adults (44 females, 19.7±2.4 yrs.) self-reported sleep behavior, and underwent the Trier Social Stress Test (TSST). Saliva samples for cortisol assessment were taken immediately before the TSST as well as repeatedly afterwards.\r Results: Average sleep duration did not appear to impact cortisol stress responses (p=.66). Contrarily, men who reported poor sleep quality showed exaggerated cortisol responses, while women exhibited blunted responses (F=3.17,p=.04). Lastly, participants who reported having trouble staying awake or keeping up enthusiasm also showed blunted cortisol responses compared to participants who did not experience such daytime dysfunctions (F=2.72, p=.06; F=1.99, p=.09, respectively).\r Conclusions: Overall, the current study suggests stress reactivity dysfunctions as one mechanism linking poor sleep with detrimental physical health outcomes in a gender-dependent manner. Furthermore, it can be speculated that the differential sleep effects may indicate that while the body is unable to maintain normal HPA functioning in an acute psychosocial stress situation after falling prey to low sleep quality, it may retain capacities to deal with challenges during times of sleep deprivation.
VHDL design and implementation of high speed blind equalizer
Creators: name: Song, Zhonghe
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Electronics and Electrical.

description: Blind equalization has significant advantages over conventional adaptive equalization because of its self-recovery ability. This ability makes blind equalization the best choice in broadcasting type communication. With increased demands for broadband data communication, the speed of blind equalization is continuously increasing. The main challenge lies in designing a high speed blind equalizer using current VLSI technology. Different blind equalization algorithms were investigated for this thesis. Comparisons of their performances and hardware complexities were performed. The CM algorithm offers excellent performance and the most robust property. A pipelined transposed direct form structure equalizer based on the CM blind equalization algorithm was proposed and designed in a VHDL model. Its performance was verified and the finite wordlength effect was investigated. VHDL model was synthesized using 0.25 mum technology.
Bioactive compounds and antioxidant capacity of Chuquiraga jussieui J.F.Gmel from the highlands of Ecuador
Creators: name: Bonilla, Daniel A. Guerrero
name: Granda-Albuja, María G.
name: Guevara, Mabel
name: Iturralde, Gabriel A.
name: Jaramillo-Vivanco, Tatiana
name: Giampieri, Francesca
name: Alvarez-Suarez, José M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Chuquiraga jussieui J.F.Gmel is grown between 3000 and 5000 meters above sea level throughout the Andean region of Ecuador and used by the indigenous populations of the Andes for medicinal purposes. Here, we determined the total phenolic, flavonoids, vitamin C and carotenoids content of the leaves and flowers of Ch. jussieui J.F.Gmel from different highlands of Ecuador as well as the capacity of a crude methanolic extract from the both parts of the plant to scavenge free radicals and protect red blood cell membranes from lipid oxidation. The leaves showed a high bioactive compound content in comparison to the flowers. The crude extract from the leaves proved to be more effective than the flowers in reducing iron and scavenging the DPPH, O2− and H2O2 radicals, as well as in protecting cellular membrane against lipid oxidation, demonstrating that Ch. jussieui J.F.Gmel represents an important source of bioactive compounds with relevant healthy properties.
Querying communities of interest in peer database networks
Creators: name: Hossain, Md. Delwar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Computer Science.

description: Peer-to-Peer (P2P) networks are used primarily for file sharing. P2P user communities are continuing to grow rapidly, but there is no specific query mechanism for communities of interest in peer database networks. Peer databases are linked to each other through acquaintances. These are individual, independently developed databases that contain local data. Many researchers have tackled the problem of query processing in P2P networks. Moreover, researchers have started to investigate community-based querying in peer database networks. The focus of this thesis is to study a query translation mechanism, to develop an algorithm for querying communities of interest in peer database networks, and to implement a prototype of this algorithm. P2P communities are formed using common claimed items. First, we investigate an existing community formation and discovery algorithm for a text file, as well as an existing query translation mechanism for peer databases. After that, we develop a community-based search algorithm for peer databases. The developed algorithm combines the aforementioned community formation and discovery with the query translation mechanisms. A prototype has been developed and experimental results are shown. An approach for discovering communities 'on the fly' is introduced and a method for optimizing the community discovery technique is shown.
Requirement based test suite generation using dependence analysis
Creators: name: Chemli, Olfa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: Requirement-based automated test case generation has been advocated as a model-based technique for generating a test suite related to individual requirements. The method proposed in this thesis consists in an approach of automating the generation of requirement-based test suites from requirements modeled by an Extended Finite State Machine (EFSM) and using EFSM Dependence Analysis. Two types of dependencies are identified between elements of the EFSM model and used to identify interactions among these elements. Patterns of interactions that affect a requirement under test are then developed to generate a test suite related to this requirement. This thesis proposes algorithms to identify data and control dependencies in the EFSM model, algorithms to use EFSM dependencies in the generation of patterns of interactions related to a requirement under test and algorithms to derive a test suite related to these patterns of interactions. Also, a Test Suite Generation program (TSG) has been developed based on these algorithms and case studies have been performed to confirm the generation of efficient test suites for individual requirements.
The Offspring Experience: Understanding Family Conversations after a Diagnosis of ALS in a Parent
Creators: name: Gondran, Gabriella
Publisher: name: Brandeis University
Year: 2023
Subjects: ALS
communication
family conversations
genetic counseling
genetic testing
Amyotrophic Lateral Sclerosis

description: Amyotrophic Lateral Sclerosis (ALS) is a progressive, life-limiting motor neuron disease withonset typically between 50 and 65 years of age. In addition to physical manifestations of disease, a diagnosis of ALS can have a significant psychological impact on patients and their families. Previous research shows that parents struggle with deciding how much to tell their offspring about their diagnosis, and there is limited published guidance for how to best discuss one’s diagnosis of ALS with their family. This study aimed to collect the opinions of individuals that have/had a parent with ALS to better understand their views around conversations with their parent(s) about their diagnosis of ALS. This study utilized an anonymous Qualtrics survey, which was hosted online from November 2022 to January 2023. Out of 45 respondents, 57.8% felts their parent communicated the right amount of information about their diagnosis, 40% felt their parents communicated too little, and only 2.2% felt their parent communicated too much information about their ALS diagnosis. Our findings show that most individuals with a parent with ALS desired more open communication especially in relation to their parent’s physical and emotional health, as well as discussions about what ALS is and what they should expect from the diagnosis. Responses showed that the manner in which this information was communicated to them played a role in how effective their family conversations were for them. Participants reported getting most of their information about what ALS is and what it means for them and their family from either the internet or a healthcare provider (HCP). This data suggests that HCPs could provide practical information about ALS and encourage patients to share this with family members as a way to facilitate the family conversations about their diagnosis. Furthermore, our survey revealed that participants felt that they had a good understanding of the inheritance of ALS, but further responses suggested unexplained discrepancies in their answers about their experiences with genetic testing. Given the complexities of ALS and the impact of genetics on available therapies, further studies should explore this continuously developing area of care for the offspring of individuals with a diagnosis of ALS.
Metabolomic profiling and anti-infective potential of Zinnia elegans and Gazania rigens (Family Asteraceae)
Creators: name: Alshymaa Abdel-Rahman Gomaa
name: Samy, Mamdouh Nabil
name: Abdelmohsen, Usama Ramadan
name: Krischke, Markus
name: Mueller, Martin J.
name: Wanas, Amira Samir
name: Desoukey, Samar Yehia
name: Kamel, Mohamed Salah
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The present study evaluates the chemical composition of Zinnia elegans and Gazania rigens based on their metabolomic profiles using liquid chromatography coupled with high-resolution mass spectrometry (LC‐HR-MS), alongside with the anti-infective activities of their ethanol extracts, as well as, different fractions. A significant difference was observed between the LC-MS profiles of the two plants such as, coumarins, sesquiterpene lactones and phenylethanoids which were characteristic for Z. elegans, while amides and phenolic acid derivatives were characteristic for G. rigens. These results highlight the chemical potential of Z. elegans and G. rigens. Furthermore, the ethyl acetate fraction of Z. elegans showed a significant antimalarial activity with IC50 values of 21.03 and 13.72 µg/mL against Plasmodium falciparum D6 and P. falciparum W2, respectively.
Naturalised Palestinians in Lebanon: experiences of belonging, identity and citizenship
Creators: name: Ghandour, Hind
Publisher: name: Swinburne
Year: 2024

description: This thesis explores the naturalization of Palestinians in Lebanon. Drawing on a series of in-depth interviews, observations, and secondary data, this research investigates the naturalization process and its aftermath among Palestinians who were granted citizenship in the late 1940s and 1950s in Lebanon. Field research was conducted over the duration of almost one year between 2013 and 2014, during which eighty participants, both naturalized Palestinians as well as refugees, were interviewed.
The involvement of cortisol and corticosteroid receptor types in mediating the effects of a high salt diet on rainbow trout (Oncorhynchus mykiss)
Creators: name: Kipp, Kathryn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Animal Physiology.

description: Rainbow trout (Oncorhynchus mykiss) are able to migrate between freshwater and seawater environments. These transitions induce remodeling of the gill, which aids in maintaining proper ionic balance in the face of changing salt and water requirements. Specific gill phenotypes for both freshwater and seawater rainbow trout have been observed, and are identifiable based on the locations and quantities of ion transporters and on the specific cell types present. Previous research has shown that internal salt loading is sufficient to induce a seawater gill phenotype in freshwater rainbow trout. The present study hypothesized that the developing phenotype was due to increases in circulating cortisol levels or corticosteroid receptor expression; this correlation was attempted by examining the time course of development of the seawater phenotype, and by examining concomitant changes in two other key osmoregulatory tissues, gut and kidney. A novel finding of the present study is that cortisol may play a role in promoting the development of a seawater phenotype in salt-fed freshwater fish, probably through regulation of corticosteroid receptor abundance rather than through modulation of cortisol levels.
Echinophora tenuifolia L. branches phytochemical profile and antiproliferative activity on human cancer cell lines
Creators: name: Marrelli, Mariangela
name: Pisani, Francesca
name: Amodeo, Valentina
name: Duez, Pierre
name: Conforti, Filomena
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: The methanolic extract of Echinophora tenuifolia L. branches and its fractions were evaluated for their in vitro cell growth inhibitory activity on different human cancer cell lines (C32, LoVo and SKBr3) and the normal BJ fibroblasts. All tested samples were effective against the melanoma cell line C32, with IC50 values ranging from 22.8 ± 0.8 to 78.7 ± 1.2 μg/mL, the antiproliferative activity of the dichloromethane fraction being significantly higher. This fraction was also effective against the LoVo adenocarcinoma cell line, with an IC50 value of 53.0 ± 2.1 μg/mL. The ethyl acetate and dichloromethane fractions showed the highest lipid peroxidation inhibitory activity, verified by means of the β-carotene bleaching test. The phytochemical profiles of E. tenuifolia branches extract were established by means of GC-MS and HPTLC. Overall, branches of E. tenuifolia L. could represent a rich source of bioactive compounds, potentially useful in the pharmaceutical field.
On the structure of the cohomology of nilpotent Lie algebras
Creators: name: Pestov, Sviatoslav
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Mathematics.

description: The exterior algebra over the centre of a Lie algebra acts on the cohomology of the Lie algebra in a natural way. Focusing on nilpotent Lie algebras, we explore the module structure afforded by this action. We show that for all two-step nilpotent Lie algebras, this module structure is non-trivial, which partially answers a conjecture of Cairns and Jessup [4]. The presence of free submodules indicates that the Lie algebra satisfies Halperin's Toral rank conjecture [11]. We prove that two specific classes of two-step nilpotent Lie algebras enjoy cohomology spaces with free submodules.
Auroglaucin-related neuroprotective compounds from Vietnamese marine sediment-derived fungus Aspergillus niveoglaucus
Creators: name: Yurchenko, Anton N.
name: Smetanina, Olga F.
name: Ivanets, Elena V.
name: Phan, Trinh Thi Hoai
name: Ngo, Ngoc Thi Duy
name: Zhuravleva, Olesya I.
name: Rasin, Anton B.
name: Dyshlovoy, Sergey A.
name: Menchinskaya, Ekaterina S.
name: Pislyagin, Eugeny A.
name: Amsberg, Gunhild Von
name: Afiyatullov, Shamil Sh.
name: Yurchenko, Ekaterina A.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Two new auroglaucin-derived compounds, niveoglaucins A (1) and B (2), together with four known related compounds were isolated from extract of the marine sediment-derived strain of Aspergillus niveoglaucus. The structures of these compounds were determined by 1D and 2D NMR spectroscopy and high resolution MS. The plausible biosynthetic pathway was proposed for new compounds 1 and 2. The neuroprotective activity in 6-OHDA-induced Parkinson’s disease cell model was shown for niveoglaucin A (1).
Iron as a risk factor for cancers of the gastrointestinal tract
Creators: name: Tait, Valerie K
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Health Sciences, Epidemiology.

description: Background. Iron is a pro-oxidant and involved in inflammatory response and endogenous nitrosation. It is a candidate modifiable risk factor for cancers of the gastrointestinal (GI) tract. Methods. A gene-disease systematic review was conducted to investigate associations between polymorphisms in iron metabolism genes, including HFE, and GI tract cancers. Data from a case-control study of dietary risk factors and esophageal adenocarcinoma (EAC) were analysed to investigate the association between HFE variants and EAC and reported intakes of red meat, iron (total and heme-bound) and EAC. Results. The results of the systematic review did not support an association between HFE variants and colorectal neoplasia. No studies were identified that investigated genetic variants in iron metabolism genes and EAC. The secondary case-control analyses found no association between HFE variants and EAC. The analyses provided evidence suggestive of an association between intake of heme iron and EAC.
Composting of soils contaminated with heavy petroleum hydrocarbons.
Creators: name: Critchley, John G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Environmental.

description: This project tested at the field scale, five on-site, non-proprietary bioremediation processes on weathered petroleum hydrocarbons from a fire fighter training area. Two bioremediation processes based on fungi (commercially produced white rot fungus, Pleurotus ostreatus, and aged, coarse wood chips, 'compost', with naturally occurring fungi) were applied with variations and compared to one control: a typical static biopile. An elevated-face compost turner was used to turn the soil in selected windrows for aeration. Statistically-based sampling was employed and quality control measures were enforced for sampling and analysis. The treatment options examined for the contaminated soil were: (1) white rot fungus and compost, (2) compost, poultry manure and turning, (3) compost, synthetic nitrogen-phosphorous-potassium fertilizer, and turning, (4) compost, the above synthetic fertilizer, and no turning, and (5) the above synthetic fertilizer, and no turning (static biopile). The compost and poultry manure process performed the best, remediating 35 tonnes of soil contaminated with 6000 mg/kg of mineral oil and grease (MOG) to the remediation criteria of 1000 mg/kg in 19 days and to less than 300 mg/kg in less than 56 days. The net rate of bioremediation was 100 mg/kg/day of MOG. The estimated cost of this process for commercial applications, excluding labour, excavation and site preparation, was $18 to $29 per tonne, depending on the cost of the poultry manure.
Volatiles composition and antioxidant activity Inula oculus-christi L. from Serbia
Creators: name: Mitić, Violeta D.
name: Ilić, Marija D.
name: Jovanović, Vesna P. Stankov
name: Djordjevic, Aleksandra S.
name: Marković, Marija S.
name: Stojanović, Gordana S.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The chemical composition of the essential oil and the volatiles obtained by static headspace (HS) of Inula oculus-christi L. is presented. The GC-MS analysis of the hydrodistilled oil resulted in the identification of 90 components, representing 92.7% of the oil. The most abundant compounds were: caryophyllene oxide (9.8%), trans-longipinocarveol (9.2%), eucalyptol (7.3%) and intermedeol (6.2%). The major constituent of I. oculus-christi L. HS volatiles was eucalyptol (87.4%). The antioxidant activity was evaluated by four different methods: 2,2-diphenyl-1-picryl-hydrazylhydrate free radical assay (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method, total reducing power (TRP), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC). Total phenolic content in (TPC) examined oil was 177.95 µg GAE/mg oil. Radical scavenging potential of the oil was promising RSC-DPPH was 57.4% and RSC-ABTS was 82.7%.
Phytochemical profiling, antioxidant, enzyme inhibition and cytotoxic potential of Bougainvillea glabra flowers
Creators: name: Hammad Saleem
name: Thet Thet Htar
name: Naidu, Rakesh
name: Gokhan Zengin
name: Ahmad, Irshad
name: Nafees Ahemad
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Plant Biology

description: In this study, phytochemical composition, antioxidant, enzyme inhibition and cytotoxic activities of methanol and dichloromethane (DCM) extracts of Bougainvillea glabra (B. glabra) flowers were investigated. Methanol extract was found to have higher total bioactive contents and UHPLC-MS analysis of methanol extract revealed the presence of well-known phenolic and flavonoid compounds. Antioxidant activities were performed by radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC), phosphomolybdenum (TAC) and metal chelating assays. From our result, we observed that methanol extract had many antioxidant compounds. The DCM extract exhibited higher cholinesterases and α-glucosidase enzyme inhibition, while methanol extract showed significant urease inhibition. Both extracts exhibited strong to moderate cytotoxicity against MCF-7, MDA-MB-231, CaSki, DU-145 and SW-480 cancer cells with IC50 values ranging from 88.49 to 304.7 µg/mL. The findings showed the B. glabra to possess considerable antioxidant, enzyme inhibition and cytotoxic potentials and therefore has potential to discover novel bioactive molecules.
Screening and characterization of medicinal plants extracts with bactericidal activity against Streptococcus mutans
Creators: name: Vargas-Segura, Alejandra Isabel
name: Silva-Belmares, Sonia Yesenia
name: Segura-Ceniceros, Elda Patricia
name: Ascacio-Valdés, Juan Alberto
name: Méndez-González, Luis
name: Ilyina, Anna
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: The aim of the present study was to perform a screening of extracts obtained from 15 medicinal plants using water (at 25 and 90 °C) or ethanol (at 25 °C), to bactericidal activity against cariogenic S. mutans ATCC 25175, as well as to carry out the preliminary phytochemical characterization of the extracts and HPLC/MS assay for selected extracts. The extractions were carried out for 5 h at 400 rpm. Only five from 45 tested extracts were selected based on their antibacterial activity. The IC50 varied from of 28 ppm for Quercus ilex up to 250 ppm for Jatropha dioica. Different polyphenolic and quinic acids, flavonoids, anthocyanin or tyrosol were identified by HPLC/MS in selected extracts from Rosa gallica L., Jatropha dioica Sessé, Mimosa tenuiflora (Willd.) Poir, Quercus ilex L., and Solanum nigrum. The obtained results confirm that selected extracts are good candidates to be used for cariogenic bacteria control.
D 2.3 Crystal plasticity
Creators: name: Phalke, Vikram
name: Forest, Samuel
name: Chang, Hyung-Jun
Publisher: name: Zenodo
Year: 2020

description: The objective of the present deliverable is to give an overview of the crystal plasticity framework and its
 industrial context. The extension of classical continuum crystal plasticity to predict size effects called strain
 gradient crystal plasticity framework (reduced-order micromorphic and augmented Lagrangian SGP approach)
 is presented. The application of the strain gradient crystal plasticity is demonstrated by a numerical example
 of a microwire torsion test.
Muggles, and quidditch, and squibs, oh my! A study of names and onomastic wordplay in translation, with a focus on the Harry Potter series
Creators: name: McDonough, Julie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Literature, Modern.

description: The goal of this thesis is to study names in the Harry Potter series and its French and Spanish translations. It therefore opens with an analysis of the names, nicknames, and titles that are found in the English series before elaborating on the characteristics that distinguish names with special significance from those without. The second chapter offers an analysis of the onomastic wordplay that can be found in the five English-language novels. Over the course of the third chapter, the reader will find (a) summaries of several translation theories, with a focus on those that pertain directly to the translation of names and onomastic wordplay, (b) a study of the strategies available to translators who are faced with loaded names, and finally, (c) an analysis of which of these strategies would seem to be the most useful in the translation of the Harry Potter series. Last, the reader will find the author's commentary on the treatment of names by Francois Menard, the French translator, by Alicia Dellepiane, who translated Harry Potter and the Philosopher's Stone into Spanish, and by Adolfo Munoz Garcia and Nieves Martin Azofra, who translated the remaining four volumes into Spanish. (Abstract shortened by UMI.)
Proxy-based single source application layer multicast media streaming
Creators: name: Zhong, Yong
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.

description: Multicasting is the data distribution from one sender to a group of receivers. Traditionally multicasting is implemented at the network layer, in the way that routers perform membership management, maintain data delivery path, and replicate and forward data. IP Multicasting is the most efficient way for group data distribution. However, it has been shown that it is extremely difficult to deploy IP Multicasting at a large scale. There are scalability issues, deployment hurdles and marketing reasons. Therefore an alternative has been proposed to shift multicast support to the application layer. This approach expects end-hosts participating in the application to perform multicast functions. This is Application-Layer Multicasting (ALM). This thesis analyzes existing ALM protocols and proposes a proxy-based single source ALM protocol which targets media streaming applications, where latency is the overlay building metric. A single source real-time media streaming application is implemented based on this protocol. Some measurements are taken both on the intranet and on the Internet. The performance data provided by the tests show that the proposed protocol introduces acceptable control overheads. Finally, based on the experience with the implemented ALM system, recommendations for future work are provided.
The effects of hydrogen ions on the resting membrane potential of frog sartorius muscle.
Creators: name: Lee, Sheu-Lun.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1968
Subjects: subject: Biology, Physiology.

description: A considerable amount of work has been done on the study of the effect of H+ ion on the resting membrane potential of frog skeletal muscle fibres and other kinds of tissue as well. The observations, however, are rather contradictory. This may be due to differences in membrane properties of these tissues. The conditions under which the experiments were carried out might also have important effects on the responses as shown in the present paper. The present study has been carried out in order to establish the effects of H+ ions on the resting membrane potential of frog sartorius muscle fibres and to investigate the mechanism by which H+ ions exert their effects. The results show that in frog sartorius muscle under relatively normal conditions, i.e. in Ringer's solution (Table II), the short term effect of lowering pH was to increase the resting membrane potential, while that of raising pH, to reduce the potential. Under these conditions the change in resting membrane potential is small, usually about 1-4 mV. Accompanying the change in resting potential is an equally rapid and reversible change in membrane resistance. Thus, the membrane resistance increases as pH falls. Consideration of the equivalent circuit of cell membrane suggests that the changes in resting membrane potential may result from membrane resistance changes. Since the responses to changes in pH persisted even in the absence of Na+ the study could be focused on the relative effects of H+ on K+ resistance and Cl- resistance of the membrane. When the relationship between the electrochemical potentials of the ions inside and outside of the cell is changed, the response to pH could provide some clues in the estimation of the relative effects of H+ ions on the component resistances of the cell membrane. It has been observed that in muscle fibre with the relation: ECl > Em > E K, lowering pH decreased the resting membrane potential. This would occur if H+ reduced the Cl- conductance of the membrane, or it decreased Cl- conductance to a greater extent than K+ conductance. The interpretation can be fitted into the response of normal cell with the relation: EK > Em > ECl, since with a higher Cl- resistance in acid the influence of ECl on Em would decrease. In each case there is a shift of Em toward EK. A theoretical consideration using the known interrelation between membrane potential, intracellular Cl- concentration and the flux of Cl- and K+ together with the measured increase in the membrane resistance in lowering the pH confirms that H + acts chiefly on Cl- resistance of the membrane in frog sartorius muscle. The physiological significance of the response with change in membrane potential to altering extracellular pH is unknown.
Investigating the role of B cells in limiting the efficacy of oncolytic virus therapy
Creators: name: Christou, Carin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: B cells limit the efficacy of oncolytic virus therapy, both through their role as antibody producers. After VSV infection, neutralizing antibodies are detectable in mouse serum four days post-infection, persisting for many weeks. Pre-existing immunity to VSV precludes viral replication in tumours and is caused by the action of anti-VSV antibodies, and not other immune compartments. I hypothesize that B cells are important in limiting the efficacy of oncolytic virus treatment, and that a lack of B cells would correlate with improved therapeutic outcome. To better study the role of B cells, I have chosen to study VSV infection and oncolytic activity in a B cell-deficient mouse model, muMT. My data indicate that while the absence of B cells correlates with the ability to deliver multiple doses of virus to the tumour and improve efficacy, under the current treatment protocol, this does not correlate with significantly improved survival.
Identifying Adverse Drug Events in Twitter Data Using Semi-Supervised Bootstrapped Lexicons
Creators: name: Benzschawel, Eric
Publisher: name: Brandeis University
Year: 2016
Subjects: natural language processing
social media
twitter
clinical NLP
pharmacovigilance
bootstrapping
lexicon-based techniques
ADE
ADR
adverse effect

description: Adverse drug event (ADE) detection serves as a primary quality of care benchmark in healthcare and plays a major role in pharmacovigilance. Social media data represents a largely untapped source of public clinical narratives which can be used to expand existing ADE tracking systems. Existing studies focus on annotation of small amounts of data to handle non-standard language usage. This study presents a new application of semi-supervised lexicon bootstrapping to flag Twitter data for potential ADEs. To do this, a new corpus sixteen times larger than the current largest, publicly available dataset was constructed and used to generate robust, bootstrapped drug and medical event lexicons. These lexicons were applied to held-out data to flag tweets containing potential ADEs. Compared to recent studies of lexicon-based ADE detection in Twitter, this method achieved competitive F1 scores and offers a robust evaluation capable of identifying severe ADEs in the social media sphere, representing important new data points relevant to existing pharmacovigilance systems.
For better, for worse: Iranian women migrants’ marriages post migration
Creators: name: Zirakbash, Farnaz
name: Farquharson, Karen
Publisher: name: Swinburne
Year: 2024

description: This study investigates whether changes of circumstances and contexts affect individuals’ patterns of interaction with their spouse. We focus on the impact of migration on the marriages of women of Iranian backgrounds who migrated to Australia after the Islamic Revolution of 1979. The results of this study indicate that after migration the women gained new societal rights. Having rights empowered the women in their relationship with their partners, enabling them to negotiate changes to the relationship that were not available to them in Iran.