cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Convex polygons in geometric triangulations
Creators: name: Dumitrescu, Adrian
name: Tóth, Csaba D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Metric Geometry (math.MG)
subject: Discrete Mathematics (cs.DM)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 05C85, 05D99, 52A10, 68W05

description: We show that the maximum number of convex polygons in a triangulation of $n$ points in the plane is $O(1.5029^n)$. This improves an earlier bound of $O(1.6181^n)$ established by van Kreveld, Löffler, and Pach (2012) and almost matches the current best lower bound of $Ω(1.5028^n)$ due to the same authors. Given a planar straight-line graph $G$ with $n$ vertices, we show how to compute efficiently the number of convex polygons in $G$.
description: 20 pages, 6 figures, a preliminary version has been presented at WADS 2015
МОДЕРНИЗМ В АСПЕКТЕ ХУДОЖЕСТВЕННО-ЭСТЕТИЧЕСКОЙ ОРГАНИЗАЦИИ ПРОИЗВЕДЕНИЙ ТАТАРСКОЙ ЛИТЕРАТУРЫ ХХ ВЕКА
Creators: name: Шагбанова Х.С.
Publisher: name: Образование и право
Year: 2022
Subjects: модернизм
татарская литература
сибирские татары
развитие культуры
национальный интерес
этническое самосознание.

description: В статье констатируется, что феномен модернизма многопланов с точки зрения эстетики, функционирования, эволюции, типологии и генезиса. Проводится мысль о том, что XX в. отмечен тенденциями к формированию различных идейных взглядов, трансформацией парадигм. В татарской литературе есть произведения, которые не вписываются в традиционную школу романтизма или реализма. Направление модерна в татарской литературе в сравнении с русским или европейским тяготеет к знаковому и символическому выражению авторской мысли, художественному обобщению и игре смыслов, использованию функциональных связей. В частности, в статье указывается, что модернизм являет собой совершенно новое направление и в творчестве сибирско-татарских поэтов и писателей, которые стремятся к психологическому обогащению внутреннего мира персонажей своих произведений.
title: Factors explaining capital market reactions during corporate, sovereign, and pandemic events
Creators: name: He, Jianan
Publisher: name: UNSPECIFIED
Year: 2022

description: The presented studies show evidence of the semi-strong market efficiency, where security prices react significantly to public announcements of the events that are crucial to firms’ valuation. We focus on two trends in capital markets. One is industry integration, where companies improve their efficiency to adapt to the changing environment. In this context, many firms choose M&A to achieve external growth and strengthen their competitiveness. The other is investment diversification, where investors actively search for low correlated markets and assets with global portfolios to reduce their investment risk. These two trends have been well explored in previous studies, where researchers provide deep insights to market participants. Nevertheless, the recent changes in regulation and market environment have put many findings in question, and some emerging markets and assets are still unfamiliar to investors. These unknowns gain more importance during the Covid-19 crisis. On the one side, the pandemic has accelerated the industry integration as many inefficient firms suffered liquidity shortages and were acquired by better-positioned firms; on the other side, investors have been searching for alternatives to diversify investment risk as central banks have injected massive liquidity into capital markets, leading to soaring inflation risk. This dissertation addresses new findings on the aforementioned trends and important implications for different groups of interests.
НАЛОГ НА ПРОФЕССИОНАЛЬНЫЙ ДОХОД В 2022 ГОДУ: ПЛЮСЫ И МИНУСЫ
Creators: name: Гаджиалиев Р.К.
Publisher: name: Образование и право
Year: 2022
Subjects: профессиональный доход
налогообложение
самозанятый гражданин
специальный налоговый режим
индивидуальный предприниматель
налоговый вычет
налоговая декларация
ставка налога
личный кабинет налогоплательщика
упрощенная система налогообложения.

description: Специальный налоговый режим «Налог на профессиональный доход» введен с 2019 г. Сейчас он применяется на территории всей страны. С 1 января 2022 г. указанный режим действует и в федеральной территории «Сириус». При применении Налога на профессиональный доход все взаимодействие с налоговым органом, в том числе регистрация, происходит онлайн через мобильное приложение «Мой налог». Самозанятые активно пользуются услугами банков и электронных площадок-партнеров проекта, которые через разработанный ФНС России API встроили функциональность мобильного приложения «Мой налог» в свои программные продукты. Основная задача в развитии этого налогового режима повышение качества предоставляемых самозанятым сервисов и услуг, увеличение поступления налоговых платежей, способствовать уменьшению безработицы, увеличению гибкости рынка труда и развитию экономики. В статье представлен анализ текущего правового статуса и механизм налогообложения самозанятых, его плюсы и минусы, а также предложены возможные пути развития самозанятости в России.
Non-parametric Estimation of Operational Risk and Expected Shortfall
Creators: name: Tursunalieva, Ainura
name: Silvapulle, Param
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper proposes improvements to advanced measurement approach (AMA) to estimating operational risks, and applies the improved methods to US business losses categorised into five business lines and three event types operational losses. The AMA involves, among others, modelling a loss severity distribution and estimating the Expected Loss and the 99.9% operational value-at-risk (OpVaR). These measures form a basis for calculating the levels of regulatory and economic capitals required to cover risks arising from operational losses. In this paper, Expected Loss and OpVaR are estimated consistently and efficiently by nonparametric methods, which use the large (tail) losses as primary inputs. In addition, the 95% intervals for the underlying true OpVaR are estimated by the weighted empirical likelihood method. As an alternate measure to OpVaR, the Expected Shortfall - a coherent risk- is also estimated. The empirical findings show that the interval estimates are asymmetric, with very large upper bounds, highlighting the extent of uncertainties associated with the 99.9% OpVaR point estimates. The Expected Shortfalls are invariably greater than the corresponding OpVaRs. The heavier the loss severity distribution the greater the difference between OpVaR and Expected Shortfall, from which we infer that the latter would provide the right level of capital to cover risks than would the former, particularly during
Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction
Creators: name: Burridge, K.
name: Lessey, E.C.
name: Marjoram, R.J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states.
Enhancing refugees’ self-reliance in Uganda – The role of cash and food assistance
Creators: name: Mastrorillo, Marina
name: Scognamillo, Antonio
name: Ginet, Camille
name: Pietrelli, Rebecca
name: D’Errico, Marco
name: Ignaciuk, Adriana
name: Mastrorillo, Marina
name: Scognamillo, Antonio
name: Ginet, Camille
name: Pietrelli, Rebecca
name: D’Errico, Marco
name: Ignaciuk, Adriana
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agricultural Finance
subject: Community/Rural/Urban Development
subject: Food Security and Poverty
subject: refugees
subject: cash transfers
subject: food transfers
subject: food security
subject: self-reliance

description: Social protection transfers are the most widespread measures adopted to stabilize refugee households’ livelihoods and alleviate their food insecurity. This paper contributes to the literature on the effectiveness of different types of support on livelihoods and productivity outcomes of one of the largest refugee populations in Africa. Taking advantage of a unique panel dataset representative of the largest part of the 1.4 million people hosted in the Uganda refugees’ settlements, this paper investigates how different social protection interventions (cash and food) are effective in alleviating food insecurity and in contributing to beneficiaries’ self-reliance. The results show that the effectiveness of transfers depends on beneficiaries’ characteristics, on context specificity, and on the outcome assessed.
description: FAO Document Repository: https://doi.org/10.4060/cc1838en
A Theoretical Study on Crystallization of Polyethylene Using Modified Weighted Density Approximation (MWDA)
Creators: name: Razeghizadeh, Alireza
name: Rafee, Vahdat
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences
subject: J.2
subject: 62G07

description: In this article, the crystallization of Polyethylene is investigated by the modified weighted density approximation. Also a direct correlation function of Polyethylene based on the RISM theory is used. The free energy of a Polyethylene is calculated using density functional theory. The crystallization together with solid and liquid densities are calculated and finally compared with the PRISM simulations and experimental results. The result obtained by modified weighted density approximation MWDA is shown to be in a better agreement with the experimental results rather than the PRISM simulations.
Improvement of Electron Field Emission in Patterned Carbon Nanotubes by High Temperature Hydrogen Plasma Treatment
Creators: name: Sellin, Paul.
name: Lian, Jun
name: Chang, Sha
name: Wang, Sigen
name: Ozsan, Ersin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In this paper, we report a significant improvement of electron field emission property in patterned carbon nanotubes films by using a high temperature (650 °C) hydrogen plasma treatment. This treatment was found to greatly increase the emission current, emission uniformity and stability. The mechanism study showed that these enhanced properties are attributed to the lowering of the potential barrier and the creation of geometrical features through the removal of amorphous carbon, catalyst particles and the saturation of dangling bonds after such a hydrogen plasma treatment.
НЕКОТОРЫЕ АСПЕКТЫ ВЕДОМСТВЕННОГО НОРМАТИВНОГО ПРАВОВОГО РЕГУЛИРОВАНИЯ ПОЛУЧЕНИЯ НЕСОВЕРШЕННОЛЕТНИМИ, СОДЕРЖАЩИМИСЯ ПОД СТРАЖЕЙ НАЧАЛЬНОГО ОБЩЕГО, ОСНОВНОГО ОБЩЕГО И СРЕДНЕГО ОБЩЕГО ОБРАЗОВАНИЯ
Creators: name: Новицкий С.С.
name: Панина С.А.
Publisher: name: Образование и право
Year: 2022
Subjects: образование несовершеннолетних
самообразование
лица
заключенные под стражу
внутренний распорядок следственных изоляторов
уголовно-исполнительная система.

description: Конституционное право несовершеннолетних лиц, заключенных под стражу, на получение основного общего образования законодательно закреплено в Федеральном законе от 15.07.1995 № 103-ФЗ «О содержании под стражей подозреваемых и обвиняемых в совершении преступлений» и Федеральном законе от 29.12.2012 № 273-ФЗ «Об образовании в Российской Федерации». Порядок получения такого образования закреплен в ведомственном нормативном правовом акте Минюста России и Минпросвещения России. При этом новая редакция Правил внутреннего распорядка следственных изоляторов уголовно-исполнительной системы содержит отдельные положения, направленные на реализацию указанного права несовершеннолетних. В этой связи в статье проанализированы соответствующие положения данного ведомственного нормативного акта.
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
Creators: name: Dutzan N.
name: Abusleme L.
name: Flick M.J.
name: Kastrup C.J.
name: Moss K.
name: Lionakis M.S.
name: Juang L.J.
name: Chun E.M.
name: Leung J.
name: Bugge T.H.
name: Moutsopoulos N.M.
name: Kram V.
name: Sibree M.
name: Castellino F.J.
name: Agler C.S.
name: Lum A.G.
name: Silva L.M.
name: Jani P.
name: Zuazo C.E.
name: Divaris K.
name: Greenwell-Wild T.
name: Doyle A.D.
name: Martin D.
name: Tran C.L.
Publisher: name: American Association for the Advancement of Science
Year: 2021

description: Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We demonstrate that commensal microbiota trigger extravascular fibrin deposition in the oral mucosa. Fibrin engages neutrophils through the aMb2 integrin receptor and activates effector functions, including the production of reactive oxygen species and neutrophil extracellular trap formation. These immune-protective neutrophil functions become tissue damaging in the context of impaired plasmin-mediated fibrinolysis in mice and humans. Concordantly, genetic polymorphisms in PLG, encoding plasminogen, are associated with common forms of periodontal disease. Thus, fibrin is a critical regulator of neutrophil effector function, and fibrin-neutrophil engagement may be a pathogenic instigator for a prevalent mucosal disease.
Higher-Order Improvements of the Sieve Bootstrap for Fractionally Integrated Processes
Creators: name: Poskitt, D.S.
name: Grose, Simone D.
name: Martin, Gael M.
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper investigates the accuracy of bootstrap-based inference in the case of long memory fractionally integrated processes. The re-sampling method is based on the semi-parametric sieve approach, whereby the dynamics in the process used to produce the bootstrap draws are captured by an autoregressive approximation. Application of the sieve method to data pre-filtered by a semi-parametric estimate of the long memory parameter is also explored. Higher-order improvements yielded by both forms of re-sampling are demonstrated using Edgeworth expansions for a broad class of statistics that includes first- and second-order moments, the discrete Fourier transform and regression coefficients. The methods are then applied to the problem of estimating the sampling distributions of the sample mean and of selected sample autocorrelation coefficients, in experimental settings. In the case of the sample mean, the pre-filtered version of the bootstrap is shown to avoid the distinct underestimation of the sampling variance of the mean which the raw sieve method demonstrates in finite samples, higher order accuracy of the latter notwithstanding. Pre-filtering also produces gains in terms of the accuracy with which the sampling distributions of the sample autocorrelations are reproduced, most notably in the part of the parameter space in which asymptotic normality does not obtain. Most importantly, the sieve bootstrap is shown to reproduce the (empirically infeasible) Edgeworth expansion of the sampling distribution of the autocorrelation coefficients, in the part of the parameter space in which the expansion is valid.
Sparse Quantum Codes from Quantum Circuits
Creators: name: Bacon, Dave
name: Flammia, Steven T.
name: Harrow, Aram W.
name: Shi, Jonathan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We describe a general method for turning quantum circuits into sparse quantum subsystem codes. The idea is to turn each circuit element into a set of low-weight gauge generators that enforce the input-output relations of that circuit element. Using this prescription, we can map an arbitrary stabilizer code into a new subsystem code with the same distance and number of encoded qubits but where all the generators have constant weight, at the cost of adding some ancilla qubits. With an additional overhead of ancilla qubits, the new code can also be made spatially local. Applying our construction to certain concatenated stabilizer codes yields families of subsystem codes with constant-weight generators and with minimum distance $d = n^{1-ε}$, where $ε= O(1/\sqrt{\log n})$. For spatially local codes in $D$ dimensions we nearly saturate a bound due to Bravyi and Terhal and achieve $d = n^{1-ε-1/D}$. Previously the best code distance achievable with constant-weight generators in any dimension, due to Freedman, Meyer and Luo, was $O(\sqrt{n\log n})$ for a stabilizer code.
description: 28 pages, 2 figures. v4. Fixed an error regarding our fault-tolerant gadgets; results unchanged. Added discussion of explicit constant factors. v5. Final published version
Healthy volunteers in US phase I clinical trials: Sociodemographic characteristics and participation over time
Creators: name: Kalbaugh C.A.
name: McManus L.
name: Fisher J.A.
name: Kalbaugh J.M.
Publisher: name: Public Library of Science
Year: 2021

description: Background Increasing the diversity of research participants is an important focus of clinical trials. However, little is known regarding who enrolls as healthy volunteers in Phase I clinical trials, which test the safety and tolerability of investigational new drugs. Despite the risk, healthy volunteers can derive no medical benefit from their participation, and they are financially compensated for enrolling. Objective This study’s purpose is to describe sociodemographic characteristics and clinical trial participation histories of healthy people who enroll in US Phase I trials. Methods The HealthyVOICES Project (HVP) is a longitudinal study of healthy individuals who have enrolled in Phase I trials. We describe self-reported sociodemographic information and Phase I trial history from HVP recruitment (May-December 2013) through the project’s end three years later (December 2016). Trial experiences are presented as medians and quartiles. Results The HVP included 178 participants. Nearly three-fourths of participants were male, and two-thirds were classified as racial and ethnic minorities. We found that some groups of participants were more likely to have completed a greater number of clinical trials over a longer timeframe than others. Those groups included participants who were male, Black, Hispanic, 30-39-years-old, unemployed, had received vocational training in a trade, or had annual household incomes of less than $25,000. Additionally, the greater the number of clinical trials participants had completed, the more likely they were to continue screening for new trials over the course of three years. Participants who pursued clinical trials as a full-time job participated in the greatest number of trials and were the most likely to continuing screening over time. Implications Participation as a healthy volunteer in US Phase I trials is driven by social inequalities. Disadvantaged groups tend to participate in a greater number of clinical trials and participate longer than more privileged groups.
НЕКОТОРЫЕ ВОПРОСЫ ВОЗМЕЩЕНИЯ ВРЕДА, ПРИЧИНЕННЫХ ДИКИМ ЖИВОТНЫМ (МЕДВЕДЯМ)
Creators: name: Петровичева Ю.В.
Publisher: name: Образование и право
Year: 2022
Subjects: возмещение вреда
дикие животные
фармакологические вещества
бурые медведи
окружающая среда
правосудие.

description: Настоящая статья посвящена нескольким процессуальным и материальным проблемам, связанных с причинением вреда правомерными действиями к диким животным т.е. бурым медведям в результате применения к ним фармакологических веществ для их успокоения. Применение процессуальных норм анализируется на примере конкретного спора, связанного с использованием положений Орхусской Конвенции «О доступе к информации, участии общественности в принятии решений и доступе общественности к правосудию по вопросам, касающимся окружающей среды», утвержденной Решением ЕС 2005/370/ ЕС Совета от 17 февраля 2005 г. (OJ 2005 L 124, стр. 1)[1] как международного правового акта на основе принципа «совместной компетенции». В области материальных норм исследуются действия физических лиц, использовавших фармакологические препараты к бурым медведям, в качестве деликтных, т.е. правонарушениям или действиям, относящихся к правомерным действиям.
НЕКОТОРЫЕ ОСОБ ЕННОСТИ ОБЕСПЕЧЕНИИ КРИМИНОЛОГИЧЕСКОЙ БЕЗОПАСНОСТИ БИОСОЦИАЛЬНОЙ СУЩНОСТИ ЧЕЛОВЕКА
Creators: name: Пинкевич Т.В.
name: Чукреев В.А.
Publisher: name: Образование и право
Year: 2022
Subjects: биосоциальная сущность человека
конвергенция
имплантация
когнитивные технологии
имплантация.

description: В статье анализируются некоторые особенности обеспечения криминологической безопасности в условиях развития и внедрения конвергенции биологических, информационных, нанои когнитивных технологий, которые при их практическом применении несут в себе значительные криминогенные риски воздействия на биосоциальную сущность человека и влияющие на уровень безопасности. В ходе анализа раскры ваются понятия «криминологическая безопасность» и «биосоциальная сущность человека», дана характеристика признаков защищенности личности. В заключении авторы приходят к выводу о необходимости создания инновационных подходов способных нейтрализовать криминогенные риски в названной сфере.
Two-dimensional smoothing of mortality rates
Creators: name: Dokumentov, Alexander
name: Hyndman, Rob J
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: We propose three new practical methods of smoothing mortality rates (the procedure known in demography as graduation) over two dimensions: age and time. The first method uses bivariate thin plate splines. The second uses a similar procedure but with lasso-type regularization. The third method also uses bivariate lasso-type regularization, but allows for both period and cohort effects. Thus the mortality rates are modelled as the sum of four components: a smooth bivariate function of age and time, smooth one-dimensional cohort effects, smooth one-dimensional period effects and random errors. Cross validation is used to compare these new methods of graduation with existing approaches.
The Teaching Peer-Review Process (TPRP) Resource Pack: The quick 'how to' guide for educators seeking to develop their practice.
Creators: name: Yates, Shaun S.
Publisher: name: London Metropolitan University
Year: 2023

description: The quality of teaching at London Metropolitan University is very good, 6th in the UK in fact! This is a testament to the university's excellent staff, in every department. To preserve this high-quality teaching standard, project lead Shaun Yates and a working group of teaching staff have composed the Teaching Peer-Review Process (TPRP). Additional feedback on the project was provided by Digby Warren, Kevin Brazant and Owen Beacock, with oversight provided by Joanna Cooke and Kelly Cooper. The mission of the TPRP is to encourage teaching staff to reflect on their own practice in view of prior student comments. An essential part of the review process is for staff to examine students' comments / feedback from module's annual student surveys. The result, therefore, is that staff will (hopefully) identify new useful practices that will better serve students. These new practices could be a fairer assessment method, a clearer way to present information, a more engaging seminar technique or something else entirely.
НЕКОТОРЫЕ ПРОБЛЕМЫ ПРИ ИСПОЛЬЗОВАНИИ БИОМЕТРИЧЕСКИХ ДАННЫХ ДЛЯ ИДЕНТИФИКАЦИИ ЛИЧНОСТИ В НОТАРИАЛЬНОЙ ПРАКТИКЕ
Creators: name: Кирсанова Е.В.
Publisher: name: Образование и право
Year: 2022
Subjects: единая биометрическая система
биометрические данные
биометрические персональные данные
идентификация личности нотариусом
нотариальные действия
цифровизация
цифровой нотариат.

description: Цифровизация диктует новые условия работы для органов и организаций, в том числе и для столь важного социального института как нотариат. В последнее время в России тема биометрической идентификации граждан находится в фокусе общественного и политического внимания. Это связано с развитием Единой биометрической системы (далее – ЕБС), для нормативно-правового обеспечения которой был принят федеральный закон от 31 декабря 2017 г. № 482-ФЗ «О внесении изменений в отдельные законодательные акты Российской Федерации» [9]. Этот закон регламентирует объединение как уже имеющихся, так и будущих биометрических данных в общую систему. Тем не менее, несмотря на положительные прогрессивные тенденции в развитии биометрической системы в России, у нотариусов остаются проблемы при использовании биометрических данных для идентификации личности. В статье автором рассмотрены лишь некоторые из существующих проблем.
Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors:Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure
Creators: name: K. Williams, Sarah
name: M. Johns, Josephine
name: M. Lauder, Jean
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Prenatal cocaine (PC) exposure negatively impacts the developing nervous system, including numerous changes in serotonergic signaling. Cocaine, a competitive antagonist of the serotonin transporter, similar to selective serotonin reuptake inhibitors (SSRIs), also blocks dopamine and norepinephrine transporters, leaving the direct mechanism through which cocaine disrupts the developing serotonin system unclear. In order to understand the role of the serotonin transporter in cocaine’s effect on the serotonergic system, we compare reports concerning PC and prenatal antidepressant exposure and conclude that PC exposure affects many facets of serotonergic signaling (serotonin levels, receptors, transporters) and that these effects differ significantly from what is observed following prenatal SSRI exposure. Alterations in serotonergic signaling are dependent on timing of exposure, test regimens, and sex. Following PC exposure, behavioral disturbances are observed in attention, emotional behavior and stress response, aggression, social behavior, communication, and like changes in serotonergic signaling, these effects depend on sex, age and developmental exposure. Vulnerability to the effects of PC exposure can be mediated by several factors, including allelic variance in serotonergic signaling genes, being male (although fewer studies have investigated female offspring), and experiencing the adverse early environments that are commonly coincident with maternal drug use. Early environmental stress results in disruptions in serotonergic signaling analogous to those observed with PC exposure and these may interact to produce greater behavioral effects observed in children of drug-abusing mothers. We conclude that based on past evidence, future studies should put a greater emphasis on including females and monitoring environmental factors when studying the impact of PC exposure.
НЕКОТОРЫЕ ПРОБЛЕМЫ ПРИМЕНЕНИЯ НОРМ, УСТАНАВЛИВАЮЩИХ ОТВЕТСТВЕННОСТЬ ЗА ФИКТИВНУЮ РЕГИСТРАЦИЮ И ФИКТИВНУЮ ПОСТАНОВКУ НА УЧЕТ ИНОСТРАННЫХ ГРАЖДАН И ЛИЦ БЕЗ ГРАЖДАНСТВА
Creators: name: Лайкова Е.А.
Publisher: name: Образование и право
Year: 2022
Subjects: уголовная ответственность
проблемы квалификации
фиктивная регистрация
миграционный учет
иностранные граждане
лица без гражданства
посредники
единый умысел
совокупность
ложные сведения.

description: В статье исследуются вопросы применения норм, устанавливающих уголовную ответственность за преступления в сфере регистрационного и миграционного учета иностранных граждан и лиц без гражданства. Особое внимание уделяется проблемам квалификации нескольких фактов совершения преступления как единого продолжаемого или как совокупности преступлений, определения субъективной стороны, разграничения рассматриваемых преступлений между собой, а также с другими смежными составами преступлений, квалификации по совокупности с другими преступлениями, а также квалификации действий иных лиц, оказывающих содействие фиктивной регистрации и фиктивной постановке на учет.
On asymptotically good ramp secret sharing schemes
Creators: name: Geil, Olav
name: Martin, Stefano
name: Martínez-Peñas, Umberto
name: Matsumoto, Ryutaroh
name: Ruano, Diego
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences
subject: 94A62, 94B27, 94B65

description: Asymptotically good sequences of linear ramp secret sharing schemes have been intensively studied by Cramer et al. in terms of sequences of pairs of nested algebraic geometric codes. In those works the focus is on full privacy and full reconstruction. In this paper we analyze additional parameters describing the asymptotic behavior of partial information leakage and possibly also partial reconstruction giving a more complete picture of the access structure for sequences of linear ramp secret sharing schemes. Our study involves a detailed treatment of the (relative) generalized Hamming weights of the considered codes.
Renal Cell Carcinoma: Where Will the State-of-the-Art Lead Us?
Creators: name: Brannon, A. Rose
name: Rathmell, W. Kimryn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Less than 20 years ago, the von Hippel-Lindau (VHL) gene was discovered and associated with sporadic renal cell carcinoma (RCC). Since then, researchers and clinicians have labored to better understand the biology driving RCC tumor progression and provide means to predict patient survival and response to therapy. Studies surrounding VHL inactivation and downstream effects continue to provide insights into these areas. Besides studies of this primary pathway, cytogenetic studies, gene expression analyses, tissue microarrays, serum proteomics, genomic resequencing, and microRNA profiling have yielded greater understanding of RCC biology and clinical presentation, and have led to a rich understanding of the heterogeneity of this disease. We review the current state of research investigations into the molecular biology of RCC, and discuss the applications to currently used clinical prognostic nomograms.
НОРМАТИВНОЕ РЕГУЛИРОВАНИЕ ВНЕУЛИЧНОГО ТРАНСПОРТА
Creators: name: Гущин В.В.
Publisher: name: Образование и право
Year: 2022
Subjects: внеуличный транспорт
метрополитен
монорельсовый транспорт
подвесная канатная дорога транспортная (далее канатная дорога)
фуникулер транспортный (наземная канатная дорога транспортная)
инфраструктура

description: Перевозка пассажиров к местам работы, учебы и отдыха внеуличным транспортом в городских агломерациях в настоящее время приобретает особую актуальность. В Росси принят специальный федеральный закон, регулирующий отношения, связанные с использованием внеуличного транспорта. Целью настоящего исследования является критические замечания по данному закона. Предметом исследования выступили нормы закона, регулирующие внеуличный транспорт. В результате проведенного исследования автор пришел к следующим выводам. Допущенные в законе терминологические неточности, противоречия в понятийно-категорийном аппарате могут неоднозначно восприниматься в правоприменительной практике, в этой связи, следует признать, что внеуличный транспорт прежде всего нуждаются в нормативном техническом регулировании.
Inhibitory prodrug mechanism for cysteine cathepsin-targeted self-controlled drug release
Creators: name: van Dalen, Floris J.
name: Verdoes, Martijn
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Tumour-associated macrophages (TAMs) support tumour development and have emerged as important regulators of therapeutic response to cytostatic agents. To target TAMs, we have developed a novel drug delivery approach which induces drug release as it inhibits cysteine cathepsin activity. This inhibitory prodrug (IPD) approach establishes a self-regulated system where drug release stops after all cysteine cathepsins are inhibited. This could improve the therapeutic window for drugs with severe side effects. We demonstrate and characterise this self-regulation concept with a fluorogenic IPD model. Next, we applied this IPD strategy to deliver cytotoxic drugs, as doxorubicin and monomethyl auristatin E, which are efficiently released and dose-dependently eliminate RAW264.7 macrophages. Lastly, by exploiting the increased cathepsin activity in TAM-like M2-polarised primary macrophages, we show that IPD-Dox selectively eliminates M2 over M1 macrophages. This demonstrates the potential of our IPD strategy for selective drug delivery and modulation of the tumour microenvironment.
Exciton-driven quantum phase transitions in holography
Creators: name: Gubankova, E.
name: Cubrovic, M.
name: Zaanen, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study phase transitions driven by fermionic double-trace deformations in gauge-gravity duality. Both the strength of the double trace deformation and the infrared conformal dimension/self-energy scaling of the quasiparticle can be used to decrease the critical temperature to zero, leading to a line of quantum critical points. The self-energy scaling is controlled indirectly through an applied magnetic field and the quantum phase transition naturally involves the condensation of a fermion bilinear which models the spin density wave in an antiferromagnetic state. The nature of the quantum critical points depends on the parameters and we find either a Berezinskii-Kosterlitz-Thouless-type transition or one of two distinct second order transitions with non-mean field exponents. One of these is an anomalous branch where the order parameter of constituent non-Fermi liquid quasiparticles is enhanced by the magnetic field. Stabilization of ordered non-Fermi liquids by a strong magnetic field is observed in experiments with highly oriented pyrolytic graphite.
description: 44 pages, 16 figures; published version
Does Pharmacogenomics Account for Variability in Control of Acute Chemotherapy-Induced Nausea and Vomiting with 5-Hydroxytryptamine Type 3 Receptor Antagonists?
Creators: name: Roederer, Mary
name: Trammel, Morgan
name: McLeod, Howard
name: Patel, Jai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Chemotherapy-induced nausea and vomiting is one of the most concerning adverse drug effects from cytotoxic chemotherapy. Despite appropriate use of antiemetic guidelines, 20–30% of patients experience breakthrough nausea and vomiting secondary to chemotherapy. To assess the variability of 5-hydroxytryptamine type 3 receptor antagonist efficacy caused by genetic variation, a review of the available literature was conducted. From the literature, three sources of pharmacogenomic variability were identified: polymorphisms associated with 5-hydroxytryptamine type 3 receptor subunits, drug metabolism via cytochromes P450, and drug transport in the body. Testing for receptor subunit polymorphisms is not applicable to a clinical setting at this time; however, cytochrome P450 2D6 testing is FDA-approved and widely accessible. Cytochrome P450 2D6 ultrarapid metabolizers and poor metabolizers displayed altered antiemetic efficacy when compared with intermediate metabolizers and extensive metabolizers. We postulate that testing for cytochrome P450 2D6 phenotypes may be the most accessible way to provide individualized antiemetic therapy in the future.
Alteration of the nasal responses to influenza virus by tobacco smoke
Creators: name: Noah, Terry L.
name: Zhou, Haibo
name: Jaspers, Ilona
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The purpose of this review is to highlight recent data regarding the impact of exposure to tobacco smoke on influenza virus infection. This is timely because of the continuing pattern for influenza to cause epidemics and pandemics.
Impact of nutrient warning labels on choice of ultra-processed food and drinks high in sugar, sodium, and saturated fat in Colombia: A randomized controlled trial
Creators: name: Murukutla N.
name: Taillie L.S.
name: Higgins I.C.A.
name: Gomez L.F.
name: Mora-Plazas M.
name: Hall M.
name: Parra M.F.
name: Bercholz M.
Publisher: name: Public Library of Science
Year: 2022

description: Objective This study assessed nutrient warnings’ impact on product selection and identification of food products high in nutrients of concern in Colombia. Methods In an online experiment (October 2020), 8,061 Colombians were randomized to a nutrient warning, guideline daily amounts (GDA), Nutri-Score, or no-label condition. They viewed two fruit drinks labeled according to their condition, one high in sugar and one not, and completed selection tasks. Next, they assessed four products high in sugar, sodium, and/or saturated fat (“high in” product). Finally, they selected which label would most discourage them from consuming a “high in” product. Results The nutrient warning performed better on most outcomes. Twenty percent of participants exposed to the nutrient warning would purchase the high-sugar fruit drink compared to GDA (24%, p<0.01), Nutri-Score (33%, p<0.001), and no label (29%, p<0.001). GDA performed slightly better than the nutrient warning in identifying the high-sugar fruit drink (91% vs 88%, p<0.001). The nutrient warning best helped participants correctly identify other “high in” products (75% vs. 23% no-label, 26% Nutri-Score, and 43% GDA, all p<0.001) and had the highest perceived message effectiveness (3.86 on 5-point scale vs. 2.97 GDA and 2.70 Nutri-Score, both p<0.001) and lowest likelihood of purchasing “high in” products (2.58 on 5-point scale vs. 3.23 GDA, 3.49 Nutri-Score, and 3.51 no label, all p<0.001). The nutrient warning most discouraged participants from wanting to consume “high in” products. Conclusions Nutrient warnings are a promising policy to help consumers identify and discourage consumption of products high in nutrients of concern. Trial registration Trial Registration: NCT04567004.
A Framework for Transceiver Designs for Multi-Hop Communications with Covariance Shaping Constraints
Creators: name: Xing, Chengwen
name: Gao, Feifei
name: Zhou, Yiqing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: For multiple-input multiple-output (MIMO) transceiver designs, sum power constraint is an elegant and ideal model. When various practical limitations are taken into account e.g., peak power constraints, per-antenna power constraints, etc., covariance shaping constraints will act as an effective and reasonable model. In this paper, we develop a framework for transceiver designs for multi-hop communications under covariance shaping constraints. Particularly, we focus on multi-hop amplify-and-forward (AF) MIMO relaying communications which are recognized as a key enabling technology for device-to-device (D2D) communications for next generation wireless systems such as 5G. The proposed framework includes a broad range of various linear and nonlinear transceiver designs as its special cases. It reveals an interesting fact that the relaying operation in each hop can be understood as a matrix version weighting operation. Furthermore, the nonlinear operations of Tomolision-Harashima Precoding (THP) and Decision Feedback Equalizer (DFE) also belong to the category of this kind of matrix version weighting operation. Furthermore, for both the cases with only pure shaping constraints or joint power constraints, the closed-form optimal solutions have been derived. At the end of this paper, the performance of the various designs is assessed by simulations.
description: 31 Pages, 9 Figures, Submitted to Signal Processing IEEE
Uniform Consistency of Nonstationary Kernel-Weighted Sample Covariances for Nonparametric Regression
Creators: name: Li, Degui
name: Phillips, Peter C. B.
name: Gao, Jiti
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: We obtain uniform consistency results for kernel-weighted sample covariances in a nonstationary multiple regression framework that allows for both fixed design and random design coefficient variation. In the fixed design case these nonparametric sample covariances have different uniform convergence rates depending on direction, a result that differs fundamentally from the random design and stationary cases. The uniform convergence rates derived are faster than the corresponding rates in the stationary case and confirm the existence of uniform super-consistency. The modelling framework and convergence rates allow for endogeneity and thus broaden the practical econometric import of these results. As a specific application, we establish uniform consistency of nonparametric kernel estimators of the coefficient functions in nonlinear cointegration models with time varying coefficients and provide sharp convergence rates in that case. For the fixed design models, in particular, there are two uniform convergence rates that apply in two different directions, both rates exceeding the usual rate in the stationary case.
О ВОПРОСЕ ПРОФИЛАКТИКИ ПРЕСТУПЛЕНИЙ
Creators: name: Маздогова З.З.
Publisher: name: Образование и право
Year: 2022
Subjects: профилактическая деятельность
следователь
процессуальные документы
преступление
информация.

description: Целью данного исследования являются вопросы профилактики преступлений подразделениями МВД России. В статье сообщается о преступлениях, но не дается глубокого и полного анализа причин и условий их совершения. Предпринята попытка выявления обстоятельств, влекущих распространенность и повторность совершения определенного вида преступлений в районе, городе, области, республике с тем, чтобы своевременно нейтрализовать эти процессы. Важную роль в данном вопросе имеет внесение обобщенных представлений и информаций по группам однородных дел, отдельным видам преступлений в том или ином регионе либо отрасли хозяйственной деятельности. В статье излагаются взгляды, посвященные актуальному вопросу – предупреждению преступлений и устранению причин, их порождающих. Вместе с тем представления правоохранительных органов о негативных явлениях и их причинах, конкретные и эффективные предложения по их устранению приобретают в современных условиях особо важное значение. Сегодня уже мало ограничивать профилактическую работу установлением причин лишь одного конкретного преступления.
The effect of environmental oxidative stress on airway inflammation
Creators: name: Auerbach, Amy
name: Hernandez, Michelle L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Asthma is an inflammatory respiratory condition with significant associated morbidity and mortality that is increasing in prevalence. Air pollution is an important factor in both the development of asthma and in asthma exacerbations. Oxidative stress as a result of exposure to air pollution and underlying genetic polymorphisms that may play a role in susceptibility to this oxidative stress are the subject of current investigation.
Inference on Self-Exciting Jumps in Prices and Volatility using High Frequency Measures
Creators: name: Maneesoonthorn, Worapree
name: Forbes, Catherine S.
name: Martin, Gael M.
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: This paper investigates the dynamic behaviour of jumps in financial prices and volatility. The proposed model is based on a standard jump diffusion process for price and volatility augmented by a bivariate Hawkes process for the two jump components. The latter process speci.es a joint dynamic structure for the price and volatility jump intensities, with the intensity of a volatility jump also directly affected by a jump in the price. The impact of certain aspects of the model on the higher-order conditional moments for returns is investigated. In particular, the differential effects of the jump intensities and the random process for latent volatility itself, are measured and documented. A state space representation of the model is constructed using both financial returns and non-parametric measures of integrated volatility and price jumps as the observable quantities. Bayesian inference, based on a Markov chain Monte Carlo algorithm, is used to obtain a posterior distribution for the relevant model parameters and latent variables, and to analyze various hypotheses about the dynamics in, and the relationship between, the jump intensities. An extensive empirical investigation using data based on the S&P500 market index over a period ending in early-2013 is conducted. Substantial empirical support for dynamic jump intensities is documented, with predictive accuracy enhanced by the inclusion of this type of specification. In addition, movements in the intensity parameter for volatility jumps are found to track key market events closely over this period.
Threat and error management for anesthesiologists: a predictive risk taxonomy
Creators: name: Guffey, Patrick
name: Park, Kellie
name: Stiegler, Marjorie P.
name: Chidester, Thomas
name: Kurup, Viji
name: Ruskin, Keith J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Patient care in the operating room is a dynamic interaction that requires cooperation among team members and reliance upon sophisticated technology. Most human factors research in medicine has been focused on analyzing errors and implementing system-wide changes to prevent them from recurring. We describe a set of techniques that has been used successfully by the aviation industry to analyze errors and adverse events and explain how these techniques can be applied to patient care.
Entanglement Generation by Communication using Phase-Squeezed Light with Photon Loss
Creators: name: Matsuoka, Fumiaki
name: Tomita, Akihisa
name: Okamoto, Atsushi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In order to implement fault-tolerant quantum computation, entanglement generation with low error probability and high success probability is required. We have proposed the use of squeezed coherent light as a probe to generate entanglement between two atoms by communication, and shown that the error probability is reduced well below the threshold of fault-tolerant quantum computation [Phys. Rev. A. {\bf 88}, 022313 (2013)]. Here, we investigate the effect of photon loss mainly due to finite coupling efficiency to the cavity. The error probability with the photon loss is calculated by the beam-splitter model for homodyne measurement on probe light. Optimum condition on the amplitude of probe light to minimize the error probability is examined. It is shown that the phase-squeezed probe light yields lower error probability than coherent-light probe. A fault-tolerant quantum computation algorithm can be implemented under 0.59 dB loss by concatenating five-qubit error correction code.