cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(4122) Arthur Goodwin Greenland
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Genetic modification of human T lymphocytes for the treatment of hematologic malignancies
Creators: name: Hoyos, V.
name: Savoldo, B.
name: Dotti, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Modern chemotherapy regimens and supportive care have produced remarkable improvements in the overall survival of patients with hematologic malignancies. However, the development of targeted small molecules, monoclonal antibodies, and biological therapies that demonstrate greater efficacy and lower toxicity remains highly desirable in hematology, and oncology in general. In the context of biological therapies, T-lymphocyte based treatments have enormous potential. Donor lymphocyte infusion in patients relapsed after allogeneic hematopoietic stem cell transplant pioneered the concept that T lymphocytes can effectively control tumor growth, and this was then followed by the development of cell culture strategies to generate T lymphocytes with selective activity against tumor cells. Over the past decade, it has become clear that the adoptive transfer of ex vivo expanded antigen-specific cytotoxic T lymphocytes promotes sustained antitumor effects in patients with virusassociated lymphomas, such as Epstein-Barr virus related post-transplant lymphomas and Hodgkin's lymphomas. Because of this compelling clinical evidence and the concomitant development of methodologies for robust gene transfer to human T lymphocytes, the field has rapidly evolved, offering new opportunities to extend T-cell based therapies. This review summarizes the most recent biological and clinical developments using genetically manipulated T cells for the treatment of hematologic malignancies.
Pressure dependence of the charge-density-wave and superconducting states in GdTe$_3$, TbTe$_3$ and DyTe$_3$
Creators: name: Zocco, D. A.
name: Hamlin, J. J.
name: Grube, K.
name: Chu, J. -H.
name: Kuo, H. -H.
name: Fisher, I. R.
name: Maple, M. B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present electrical resistivity and ac-susceptibility measurements of GdTe$_3$, TbTe$_3$ and DyTe$_3$ performed under pressure. An upper charge-density-wave (CDW) is suppressed at a rate of $\mathrm{d}T_{\mathrm{CDW,1}}/\mathrm{d}P$ = $-$85 K/GPa. For TbTe$_3$ and DyTe$_3$, a second CDW below $T_{\mathrm{CDW,2}}$ increases with pressure until it reaches the $T_{\mathrm{CDW,1}}$($P$) line. For GdTe$_3$, the lower CDW emerges as pressure is increased above $\sim$ 1 GPa. As these two CDW states are suppressed with pressure, superconductivity (SC) appears in the three compounds at lower temperatures. Ac-susceptibility experiments performed on TbTe$_3$ provide compelling evidence for bulk SC in the low-pressure region of the phase diagram. We provide measurements of superconducting critical fields and discuss the origin of a high-pressure superconducting phase occurring above 5 GPa.
description: 8 pages, 5 figures
ASSESSMENT OF BIOSAFETY PRACTICE AND ASSOCIATED FACTORS IN CLINICAL LABORATORY WORKERS AMONG GOVERNMENT HOSPITALS IN ADDIS ABABA, ETHIOPIA
Creators: name: Alexsander Seyoum Hagos
Publisher: name: Zenodo
Year: 2014

description: Background: Biosafety is an important practice in all laboratory settings especially in developing countries where standard operating procedures are lacking. There is only limited information about biosafety practices in government hospital laboratories in Addis Ababa.

Objective: To assess the situation of biosafety practice and associated factors in clinical laboratory workers among government Hospitals in Addis Ababa, Ethiopia

Method: Cross-sectional study design was conducted from March to May 2014; in all government Hospitals of Addis Ababa. A total of 290 laboratory professionals were participated about their biosafety practice and its associated factors using structured questionnaire to assess the structural and functional aspects of Biosafety Practice of laboratories. Data were coded and entered by Epi Info and Exported to SPSS V.20 for analysis. Bivariate and multivariate analysis were also used to identify factors that affect the outcome variable and to examine the effect of selected variables on laboratory personnel practice toward biosafety practice by using Odds Ratio (OR) with a 95% Confidence Interval. P- Value less than 0.05 were taken as statistically significant. Variables that were found with a statistically significant association (p<0.05) at bivariate logistic analysis were entered and analyzed by multiple logistic regression analysis
Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia
Creators: name: Okur, F.V.
name: Peshwa, M.V.
name: Yvon, E.
name: Heslop, H.
name: Li, L.
name: Carrum, G.
name: Brenner, M.K.
name: Mims, M.P.
name: Dotti, G.
name: Fratantoni, J.C.
name: Biagi, E.
Publisher: name: Elsevier Inc.
Year: 2011

description: Background aims. Several studies have demonstrated that the immunogenicity of chronic lymphocytic leukemia (CLL) cells can be increased by manipulation of the CD40/CD40-ligand (CD40L) pathway. Although immunologic, and perhaps clinical, benefits have been obtained with an autologous CLL tumor vaccine obtained by transgenic expression of CD40L and interleukin (IL)-2, there is little information about the optimal gene transfer strategies. Methods. We compared two different CLL vaccines prepared by adenoviral gene transfer and plasmid electroporation, analyzing their phenotype and immunostimulatory activity. Results. We found that higher expression of transgenic CD40L was mediated by adenoviral gene transfer than by plasmid transduction, and that adenoviral transfer of CD40L was associated with up-regulation of the co-stimulatory molecules CD80 and CD86 and adhesion molecule CD54. In contrast, transgenic IL-2 secretion was greater following plasmid transduction. These phenotypic differences in the vaccines were associated with different functionality, both ex vivo and following administration to patients. Thus adenoviral vaccines induced greater activation of leukemia-reactive T cells ex vivo than plasmid vaccines. In treated patients, specific T-cell (T helper 1 (Th1) and T helper 2 (Th2)) and humoral anti-leukemia responses were detected following administration of the adenoviral vaccine (n = 15), while recipients of the plasmid vaccine (n = 9) manifested only a low-level Th2 response. Progression-free survival at 2 years was 46.7% in the adenoviral vaccine recipients, versus 11.1 % in those receiving plasmid vaccine. Conclusions. CLL vaccines expressing the same transgenes but produced by distinct methods of gene transfer may differ in the polarity of the immune response they induce in patients.
(4123) James Kitchin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Location-aware sign-on and key exchange using attribute-based encryption and Bluetooth beacons
Creators: name: Portnoi, Marcos
name: Shen, Chien-Chung
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: This work presents a mobile sign-on scheme, which utilizes Bluetooth Low Energy beacons for location awareness and Attribute-Based Encryption for expressive, broadcast-style key exchange. Bluetooth Low Energy beacons broadcast encrypted messages with encoded access policies. Within range of the beacons, a user with appropriate attributes is able to decrypt the broadcast message and obtain parameters that allow the user to perform a short or simplified login. The effect is a "traveling" sign-on that accompanies the user throughout different locations.
description: Communications and Network Security (CNS), 2013 IEEE Conference on. arXiv admin note: text overlap with arXiv:1410.0983
(4116) Joseph Bedford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MICROALGAE PEPTIDES IN CARDIOVASCULAR DISEASE PREVENTION: STRUCTURE ELUCIDATION,BIOACTIVITY INVESTIGATION,AND IN SILICO MOLECULAR MODELING ANALYSIS
Creators: name: LI, YUCHEN
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Bioactive food-derived peptides have been increasingly studied and the multiple health benefits they provide have been acknowledged. Since the most investigated sources of bioactive peptides are eggs, meat, fish, soybean, wheat, milk, and their derivatives or byproducts. More recently, some attention is being paid to microalgae, a promising unconventional protein source. On this basis, the PhD thesis was focused on the evaluation of the potential of microalgae to generate peptides with cardiovascular-promoting effects, especially hypotensive and antidiabetic activities, by targeting two therapeutic agents ? angiotensin I converting enzyme (ACE) and peptidyl-peptidase IV (DPP-IV), respectively. To achieve this objective, multidisciplinary approaches were employed, involving peptidomic techniques to profile the peptide sequences, biochemical tools to analyze the bioactivity, and emerging molecular modelling methods to predict potentially bioactive peptides as well as to explore their possible mechanism of action. Briefly, the results showed that the protein hydrolysates from spirulina, PBP and chlorella generally presented significant ACE and/or DPP-IV inhibitory activities. By comparison, peptic hydrolysate of spirulina protein showed the best in vitro inhibiting effect on ACE with IC50 value of 0.1 � 0.04 mg/mL while the tryptic hydrolysate of PBP stands out with the lowest IC50 value of DPP-IV inhibition (0.5 ? 1.0 mg/mL). Noticeably, when working on the intestinal Caco-2 cells, all the hydrolysates turned to be less bioactive than in vitro, indicating their susceptibility to metabolic degradation by intestinal cells. This is further in line with the kinetics of DPP-IV inhibition of PBP tryptic hydrolysate working on the intestinal cells, which showed the decreasing trend of its bioactivity after incubation with Caco-2 cells for 3 h. This reflects the issue of peptide bioavailability, which could be stressed in further studies. Moreover, peptides Pep2 (FLKPLGSGK), Pep7 (QIYTMGK), Pep8 (FLFVAEAIYK), and Pep10 (QHAGTKAK) were screened from hydrolysates of chlorella protein by peptidomics combined with docking and MD. The modelling results indicated that they may block the important domain of both ACE and DPP-IV and generate dynamically stable peptide-ACE/DPP-IV complexes. Based on this theoretical evidence, further study will focus on the verification of their actual bioactivity by biochemical approaches. In conclusion, the bioactivity investigation of microalgae protein hydrolysates provides new evidence that microalgae protein are great sources to produce peptides with health-promoting properties. The exclusive data of peptide characterization makes a foundation to isolate single bioactive peptides as well as offers useful structural and functional implications for food ingredient formulation or pharmacological use.
(4118) Samuel Cooper
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The fast molecular outflow in the Seyfert galaxy IC5063 as seen by ALMA
Creators: name: Morganti, Raffaella
name: Oosterloo, Tom
name: Oonk, J. B. R.
name: Frieswijk, Wilfred
name: Tadhunter, Clive
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use high-resolution (0.5 arcsec) CO(2-1) observations performed with ALMA to trace the kinematics of the molecular gas in the Seyfert 2 galaxy IC5063. A fast outflow of molecular gas extends along the entire radio jet, with the highest outflow velocities about 0.5kpc from the nucleus, at the location of the brighter hot-spot in the W lobe. The data show that a massive, fast outflow with velocities up to 650 km/s of cold molecular gas is present, in addition to one detected earlier in warm H2, HI and ionised gas. Both the central AGN and the radio jet could energetically drive the outflow. However, the characteristics of the outflowing gas point to the radio jet being the main driver. This is important, because IC5063, although one of the most powerful Seyfert galaxies, is a relatively weak radio source (P = 3x10^23 W/Hz). All the observed characteristics can be described by a scenario of a radio plasma jet expanding into a clumpy medium, interacting directly with the clouds and inflating a cocoon that drives a lateral outflow into the interstellar medium. This model is consistent with results obtained by recent simulations such as those of Wagner et al.. A stronger, direct interaction between the jet and a gas cloud is present at the location of the brighter W lobe. Even assuming the most conservative values for the conversion factor CO-to-H2, the mass of the outflowing gas is between 1.9 and 4.8x10^7 Msun. These amounts are much larger than those of the outflow of warm gas (molecular and ionized) and somewhat larger than of the HI outflow. This suggests that most of the observed cold molecular outflow is due to fast cooling after being shocked. This gas is the end product of the cooling process. Our CO observations demonstrate that fast outflows of molecular gas can be driven by relativistic jets.
description: Accepted for publication in A&A. 11 pages, 8 figures
'USED SCORES'. LINEE TEORICHE E OPERATIVE PER L�INDAGINE DEL RAPPORTO TRA ESECUTORI E MATERIALI PERFORMATIVI
Creators: name: CESTINO, GIOVANNI
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: This study provides a theoretical and analytical framework to investigate the relationship between performers and their materials (scores, parts, etc.) in the Western art music context. Whilst the literature has focused on annotation practice ? and thus on the informational content of scores ? the approach here is extended to the practices of reading and the material alteration of the performative support. Textual artifacts are thus considered both for their role in the performative process, and for the cultural affordance of the content they convey. Combining recent anthropological perspectives on creative processes with textual criticism methods, this study delves into each of the three practices with a constant reference to numerous sources, belonging to relevant mid-XX century performers who had a unique relationship with their materials. In order to derive some analytical tools ? potentially suitable for future case studies ? the dissertation focuses on an example: the materials of Berg's Lyrische Suite employed by the LaSalle Quartet and its founder, Walter Levin. On one hand, this investigation reaffirms the relevance of such sources for different scholarly perspectives, including reception history and performance practice. On the other, this study claims for a reconsideration of text-performance dichotomy by relocating it in performers? perspectives. Lastly, it suggests a multi-disciplinary approach to textual artifacts which aims to fill the gap between opposite approaches like musical philology and performance studies, towards an 'anthropology of the musical text'.
Asymptotic Completeness in Quantum Field Theory: Translation Invariant Nelson Type Models Restricted to the Vacuum and One-Particle Sectors
Creators: name: Gérard, Christian
name: Møller, Jacob Schach
name: Rasmussen, Morten Grud
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 81Q10, 47A40, 81T10, 81U30

description: Time-dependent scattering theory for a large class of translation invariant models, including the Nelson and Polaron models, restricted to the vacuum and one-particle sectors is studied. We formulate and prove asymptotic completeness for these models. The translation invariance imply that the Hamiltonians considered are fibered with respect to the total momentum. On the way to asymptotic completeness we determine the spectral structure of the fiber Hamiltonians, establish a Mourre estimate and derive a geometric asymptotic completeness statement as an intermediate step.
(4119) Nanny [Cooper]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Adverse events following infusion of T cells for adoptive immunotherapy: A 10-year experience
Creators: name: Torrano, V.
name: Rooney, C.M.
name: Gottschalk, S.
name: Gee, A.P.
name: Bollard, C.M.
name: Heslop, H.E.
name: Louis, C.U.
name: Arce, J.A.
name: Hanley, P.J.
name: Cruz, C.R.
name: Liu, H.
name: Brenner, M.K.
name: Lin, Y.-F.
name: Leen, A.M.
name: Dotti, G.
name: Savoldo, B.
Publisher: name: Elsevier Inc.
Year: 2010

description: Background aims. The Food and Drug Administration (FDA) currently recommends at least 4 h of recipient monitoring after T cell infusions to detect early infusion reactions. Recent catastrophic reactions to 'first-in-man' biologic agents have emphasized the importance of this rule for initial studies of new products. The value of such monitoring for better established agents is less obvious. Methods. We reviewed infusion-related adverse events (AE) following administration of ex vivo-expanded T cell products (antigen-specific cytotoxic T lymphocytes, allodepleted T cells, and genetically modified T cells) on investigational new drug (IND) studies in our center. Results. From 1998 to 2008, we infused 381 T cell products to 180 recipients, enrolled on 18 studies, receiving T cells targeting malignancies or post-transplant viral infections. There were no grade 34 infusion reactions during initial monitoring or 24-h follow-up. Twenty-four mild (grade 12) AE occurred in 21 infusions either during or immediately following infusion (up to 6 h), most commonly nausea and vomiting (10/24, 41.6%), probably because of the dimethyl sulfoxide cryoprotectant, and hypotension (20.8%), attributable to diphenhydramine pre-medication. Twenty-two additional non-severe events were reported within 24 h of infusion, most commonly culture-negative fever, chills and nausea. An increased risk of adverse events was associated with age [incidence rate ratio (IRR) 0.98; 95% confidence interval (CI) 0.961.00, P 0.05], while an increased risk of immediate infusion-related events was higher in patients reporting allergies (IRR 2.72, 95% CI 1.007.40, P 0.05); sex, disease type and T cell source (allogeneic or autologous) had no effect on frequency of adverse events. Conclusions. Infusion of these T cell products was safe in the outpatient setting and associated with no severe reactions, so monitoring for 1 h after infusion is probably sufficient. As many of the AE were attributable to diphenhydramine premedication, a lower dose (0.25 mg/kg) should be selected.
Positive scalar curvature on foliations
Creators: name: Zhang, Weiping
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: We generalize classical theorems due to Lichnerowicz and Hitchin on the existence of Riemannian metrics of positive scalar curvature on spin manifolds to the case of foliated spin manifolds. As a consequence, we show that there is no foliation of positive leafwise scalar curvature on any torus, which generalizes the famous theorem of Schoen-Yau and Gromov-Lawson on the non-existence of metrics of positive scalar curvature on torus to the case of foliations. Moreover, our method, which is partly inspired by the analytic localization techniques of Bismut-Lebeau, also applies to give a new proof of the celebrated Connes vanishing theorem without using noncommutative geometry.
description: 28 pages. Title changed. Revised version to appear in Annals of Mathematics. arXiv admin note: text overlap with arXiv:1204.2224
An Empirical Study on Configuration-Related Code Weaknesses
Creators: name: Medeiros, Flávio
Publisher: name: Zenodo
Year: 2020
Subjects: Configurable Systems, Preprocessors, Code Weaknesses

description: Developers often use the C preprocessor to handle variability and portability. However, many researchers and practitioners criticize the use of preprocessor directives because of their negative effect on code understanding, maintainability, and error proneness. This negative effect may lead to configuration-related code weaknesses, which appear only when we enable or disable certain configuration options. A weakness is a type of mistake in software that, in proper conditions, could contribute to the introduction of vulnerabilities within that software. Configuration-related code weaknesses may be harder to detect and fix than weaknesses that appear in all configurations, because variability increases complexity. To address this problem, we propose a sampling-based white-box technique to detect configuration-related weaknesses in configurable systems. To evaluate our technique, we performed an empirical study with 24 popular highly configurable systems that make heavy use of the C preprocessor, such as Apache Httpd and Libssh. Using our technique, we detected 57 configuration-related weaknesses in 16 systems. In total, we found occurrences of the following five kinds of weaknesses: 30 memory leaks, 10 uninitialized variables, 9 null pointer dereferences, 6 resource leaks, and 2 buffer overflows. The corpus of these weaknesses is a valuable source to better support further research on configuration-related code weaknesses.
THE DOUBLE LIFE OF THE APOPTOSIS INDUCING FACTOR (AIF): THE PRO-VITAL ROLE OF A PRO-DEATH PROTEIN
Creators: name: COCOMAZZI, PAOLO GIUSEPPE
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Beside its apoptotic function, the Apoptosis Inducing Factor (AIF), a highly conserved mitochondrial flavoprotein, plays a pro-vital role in eukaryotic cells through its interaction with CHCHD4, a mitochondrial protein that contributes to oxidative folding of respiratory complexes? subunits. A unique feature of AIF is the ability to form a tight, air-stable charge-transfer complex (CT complex) upon reaction with NAD(H), which leads to protein dimerization modulating the affinity for its ligands. To date, nine point mutations of the human AIF gene were found to cause rare and severe neurodegenerative mitochondriopathies. To define the molecular bases of the pathogenicity of AIF variants, we selected a set of AIF mutations (G337E, D236G, G261S and F133L) and investigated their effects on both AIF molecular properties and its interaction with CHCHD4. To this aim, a combination of biophysical techniques, Microscale Thermophoresis (MST) and structural biology was used. AIF variants CT complex stability was evaluated studying its reoxidation by O2. Interestingly, CT complex of G337E and G261S forms displayed a faster oxidation compared to wild type AIF, indicating a lower stability. Moreover, the 3D structures of the CT complex of AIF-D236G and of AIF-F133L both in oxidized and CT complex state were obtained, showing, however, no significant structural rearrangements with respect to the wild type protein. Hence, we investigated possible alterations of the interaction with CHCHD4 induced by AIF pathogenic mutations. Through a MST approach, for the first time we quantitatively studied redox-dependent effects of AIF amino acid replacements on its affinity for CHCHD4, revealing a possible involvement of the G337 residue in protein-protein complex formation. We characterized the AIF-CHCHD4 complex also from a structural point of view using the Small-Angle X-ray Scattering (SAXS) technique, through which we identified a putative interaction region between the two proteins. In addition, all SAXS models obtained revealed that the solvent-exposed G337 residue is localized in the neighborhood of the identified region, in agreement with a possible role of this residue in complex formation. Our results, not only shed new light on AIF-CHCHD4 relationship, but also provide a possible explanation of the pathogenicity of the AIF G337E allelic variant.
Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine
Creators: name: Dotti, G.
name: Savoldo, B.
name: Yvon, E.
name: Biagi, E.
name: Lu, A.
name: Heslop, H.E.
name: Foster, A.E.
name: Goodell, M.A.
name: Brenner, M.K.
name: Okur, F.V.
name: Carrum, G.
Publisher: name: Nature Publishing Group
Year: 2010

description: Side-population (SP) analysis identifies precursor cells in normal and malignant tissues. Cells with this phenotype have increased resistance to many cytotoxic agents, and may represent a primary drug-resistant population in malignant diseases. To discover whether drug-resistant malignant SP cells are nonetheless sensitive to immune-mediated killing, we first established the presence of a malignant CD5+ CD19+ SP subset in the blood of 18/21 subjects with B-cell chronic lymphocytic leukemia (B-CLL). We examined the fate of these cells in six of these individuals who received autologous human CD40 ligand and interleukin-2 (hCD40L/IL-2) gene-modified tumor cells as part of a tumor vaccine study. Vaccinated patients showed an increase in B-CLL-reactive T cells followed by a corresponding decline in circulating CD5+ CD19+ SP cells. T-cell lines and clones generated from vaccinated patients specifically recognized B-CLL SP tumor cells. Elimination of SP cells is likely triggered by their increased expression of target antigens, such as receptor for hyaluronan-mediated motility (RHAMM), after stimulation of the malignant cells by hCD40L, as CD8+ RHAMM-specific T cells could be detected in the peripheral blood of immunized patients and were associated with the decline in B-CLL SP cells. Hence, malignant B cells with a primary drug-resistant phenotype can be targeted by T-cell-mediated effector activity after immunization of human subjects.
ESSAYS ON MONETARY POLICY AND CYCLICAL CONVERGENCE IN THE EURO AREA
Creators: name: RIVOLTA, GIULIA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: This work contributes to the literature about the Euro-area monetary policy analysing the effects of unconventional measures, the conduct of monetary policy by the European central bank and the effects of the crisis on the economic structures of member countries. The first chapter deals with the effects of unconventional monetary policy measures implemented since 2007 to cope with the financial and sovereign debt crisis. The focus is on government bond yields as they as they became the direct expression of the sovereign debt crisis in the Euro area, and it deals with two aspects of the transmission mechanism: the first one is the expectational channel and the second one is the effect of liquidity injections. Results show that the effect of unconventional monetary policies are not unique inside the monetary union but vary across countries and over time. In particular, the unfolding of the European sovereign debt crisis completely changed the impact of liquidity injections as they led to a rise in interest rate spreads for highly indebted countries. The second chapter analyzes the conduct of monetary policy in the Euro area over the period 1999-2013 by estimating several monetary policy reaction functions with time-varying coefficients and heteroskedastic error terms. This allows to evaluate whether relevant shifts in the conduct of monetary policy occurred and whether the current financial crisis had an influence on that. Results show that the sensitivity of the ECB towards inflation and output gap changed along the time span and mainly after 2008 as it also started to respond to new variables like bank loans and sovereign bond yield spreads. The third chapter analyzes the effects of the recent economic crisis in the Euro area in light of international structural macroeconomic relationships. This is achieved through a conditional forecast exercise. By comparing the forecast with the actual path of the Euro-area variables it is possible to evaluate whether, given the effects of the crisis in US, pre-crisis structural macroeconomic relationship are able to explain Euro-area economic developments during the crisis. Results show that the effects of the crisis have been much more heterogeneous than what implied by structural relationships and the crisis shock suggesting that either a structural break or a strong idiosyncratic shock affected the Euro area after 2008. Finally, the sovereign debt crisis by itself seems not to be able to explain neither business-cycle and inflation heterogeneity, nor the recent recession and economic slack.
PPM1A and PPM1B act as IKKβ phosphatases to terminate TNFα-induced IKKβ-NF-κB activation
Creators: name: Dotti, G.
name: Yu, Y.
name: Shen, T.
name: Lin, X.
name: Fu, S.
name: Chu, M.
name: Zhang, D.
name: Lu, X.
name: Sun, W.
name: Pass, A.K.
name: Tan, X.
name: Savoldo, B.
name: Yang, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: IKKβ serves as a central intermediate signaling molecule in the activation of the NF-κB pathway. However, the precise mechanism for the termination of IKKβ activity is still not fully understood. Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, PPM1A and PPM1B, as IKKβ phosphatases. Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKβ at Ser177 and Ser181 and termination of IKKβ-induced NF-κB activation. PPM1A and PPM1B associate with the phosphorylated form of IKKβ, and the interaction between PPM1A/PPM1B and IKKβ is induced by TNFα in a transient fashion in the cells. Furthermore, knockdown of PPM1A and PPM1B expression enhances TNFα-induced IKKβ phosphorylation, NF-κB nuclear translocation and NF-κB-dependent gene expression. These data suggest that PPM1A and PPM1B play an important role in the termination of TNFα-mediated NF-κB activation through dephosphorylating and inactivating IKKβ.
Supplementary Material for CSCW paper: "Don't Disturb Me: Challenges of Interacting with Software Bots on Open Source Software Projects"
Creators: name: Anonymous
Publisher: name: Zenodo
Year: 2020
Subjects: Software Bots, GitHub Bots, Human-bot Interaction, Open Source Software, Collaborative Development, Software Engineering

description: Interview Script and Codebook for the paper "Don't Disturb Me: Challenges of Interacting with Software Bots on Open Source Software Projects"
Secure Zones: An Attribute-Based Encryption advisory system for safe firearms
Creators: name: Portnoi, Marcos
name: Shen, Chien-Chung
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: This work presents an application of the highly expressive Attribute-Based Encryption to implement Secure Zones for firearms. Within these zones, radio-transmitted local policies based on attributes of the user and the firearm are received by embedded hardware in the firearms, which then advises the user about safe operations. The Secure Zones utilize Attribute-Based Encryption to encode the policies and user attributes, and providing privacy and security through it cryptography. We describe a holistic approach to evolving the firearm to a cyber-physical system to aid in augmenting safety. We introduce a conceptual model for a firearm equipped with sensors and a context-aware software agent. Based on the information from the sensors, the agent can access the context and inform the user of potential unsafe operations. To support Secure Zones and the cyber-physical firearm model, we propose a Key Infrastructure Scheme for key generation, distribution, and management, and a Context-Aware Software Agent Framework for Firearms.
description: Communications and Network Security (CNS), 2013 IEEE Conference on. arXiv admin note: substantial text overlap with arXiv:1411.1733
Immunotherapy of human cancers using gene modified T lymphocytes
Creators: name: Dotti, G.
name: Brenner, M.K.
name: Vera, J.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.
IMOTHEP_D7.1_Project-Identity_VF
Creators: name: Keranen, Jetta
name: Favier, Peggy
Publisher: name: Zenodo
Year: 2020
Subjects: project identity, graphic identity, H2020 project, IMOTHEP, HEP, INEA

description: The deliverable D7.1: “Project consortium identity” describe the creation of a graphic identity for the H2020 IMOTHEP project.
Physical properties of solar polar jets: A statistical study with Hinode XRT data
Creators: name: Paraschiv, A. R.
name: Bemporad, A.
name: Sterling, A. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The target of this work is to investigate the physical nature of polar jets in the solar corona and their possible contribution to coronal heating and solar wind flow based on the analysis of X-ray images acquired by the Hinode XRT telescope. We estimate the different forms of energy associated with many of these small-scale eruptions, in particular the kinetic energy and enthalpy. Two Hinode XRT campaign datasets focusing on the two polar coronal holes were selected to analyze the physical properties of coronal jets; the analyzed data were acquired using a series of three XRT filters. Typical kinematical properties (e.g., length, thickness, lifetime, ejection rate, and velocity) of 18 jets are evaluated from the observed sequences, thus providing information on their possible contribution to the fast solar wind flux escaping from coronal holes. Electron temperatures and densities of polar-jet plasmas are also estimated using ratios of the intensities observed in different filters. We find that the largest amount of energy eventually provided to the corona is thermal. The energy due to waves may also be significant, but its value is comparatively uncertain. The kinetic energy is lower than thermal energy, while other forms of energy are comparatively low. Lesser and fainter events seem to be hotter, thus the total contribution by polar jets to the coronal heating could have been underestimated so far. The kinetic energy flux is usually around three times smaller than the enthalpy counterpart, implying that this energy is converted into plasma heating more than in plasma acceleration. This result suggests that the majority of polar jets are most likely not escaping from the Sun and that only cooler ejections could possibly have enough kinetic energy to contribute to the total solar wind flow.
description: 21 pages, 10 figures, Submitted and accepted for publishing in Astronomy and Astrophysics journal
Sup-norm bounds for Eisenstein series
Creators: name: Huang, Bingrong
name: Xu, Zhao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11F12

description: The paper deals with establishing bounds for Eisenstein series on congruence quotients of the upper half plane, with control of both the spectral parameter and the level. The key observation in this work is that we exploit better the structure of the amplifier by just supporting on primes for the Eisenstein series, which can use both the analytic method as Young did to get a lower bound for the amplifier and the geometric method as Harcos--Templier did to obtain a more efficient treatment for the counting problem.
description: 17 pages. Comments are welcome!
PET imaging of T cells derived from umbilical cord blood
Creators: name: Simmons, P.J.
name: Huls, H.
name: Manuri, P.R.
name: Singh, H.
name: Bollard, C.
name: Gelovani, J.G.
name: Najjar, A.M.
name: Olivares, S.
name: Shpall, E.J.
name: Lee, D.A.
name: Nishii, R.
name: Alauddin, M.
name: Mukhopadhyay, U.
name: Champlin, R.E.
name: Dotti, G.
name: Cooper, L.J.N.
Publisher: name: Nature Publishing Group
Year: 2009

description: Progress in understanding tumor-specific immune responses, genetic engineering and ex vivo manufacturing, have led to improvements in the safety and feasibility of adoptive transfer of genetically modified T cells. However, rational design, application and evaluation of T-cell therapy requires monitoring methods that can detect, locate and serially quantify these cell-mediated immune responses. Currently, such monitoring methods are chiefly limited to invasive techniques to investigate recovered cell populations for in vitro measurements including histology, flow cytometry, Q-PCR or the detection of cytokines. These assays provide episodic glimpses of the bio distribution of T cells and are limited by the number and sites of sampling. In contrast, imaging provides a methodology for quantitative, non-invasive, longitudinal and spatial in vivo information about the dynamic processes of infused T cells.
(4113) Honor Mary Stanhope Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression
Creators: name: Heslop, H.E.
name: Brenner, M.K.
name: Dotti, G.
name: Carrum, G.
name: Savoldo, B.
name: Andreeff, M.
name: Lu, A.
name: Biagi, E.
name: Goodell, M.A.
name: Okur, F.V.
name: Yvon, E.
name: Foster, A.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Cancer precursor/progenitor cells may initiate and sustain the growth of tumors, but evidence for their existence in human disease is indirect, relying on their it in vitro it properties and animal models. More directly, specific elimination of these rare cells from cancer patients should produce a delayed but progressive disappearance of differentiated malignant progeny. Here, we describe selective eradication of a putative precursor population in a patient with B-cell chronic lymphocytic leukemia, followed 6 months later by a progressive loss of mature tumor cells without further treatment. This outcome supports the presence of a rare population of precursor/progenitor cells in human malignancies, and suggests benefit from their removal.
Repetitive noninvasive monitoring of hsvl-tk-expressing t cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU
Creators: name: Savoldo, B.
name: Dotti, G.
name: Alauddin, M.
name: Kornblau, S.
name: Gelovani, J.G.
name: Borne, A.
name: Gonzalez, C.
name: Paolillo, V.
name: Jackson, J.
name: Shpall, E.J.
name: Decker, W.K.
name: Najjar, A.
name: Steiner, D.
name: Tian, M.
name: Smith, A.
name: Mawlawi, O.
name: Marini, F.
name: Uthamanthil, R.
name: Bollard, C.M.
name: Brammer, D.
name: Cooper, L.J.N.
Publisher: name: Cell Press
Year: 2009

description: Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) has been successfully used to treat patients with different types of cancer. However, the long-term spatial-temporal dynamics of the distribution of systemically infused CTLs rlargely unknown. Noninvasive imaging of adoptively transferred CTLs using molecular-genetic reporter imaging with positron emission tomography and computed tomography (PET-CT) represents an innovative approach to understanding the long-term migratory patterns and therapeutic potential of adoptively transferred T cells. Here we report the application of repetitive PET-CT imaging with [18F]fluoro-5-ethyl-1-beta-D- arabinofuranosyluracil (18F-FEAU) in two nonhuman primates demonstrating that autologous polyclonal macaque T lymphocytes activated and transduced with a retroviral vector encoding for the sr39 mutant herpes simplex virus 1 thymidine kinase (sr39HSV1-tk) reporter gene can be detected after intravenous infusion in discrete lymphoid organs and in sites of inflammation. This study represents a proof of principle and supports the application of 18F-FEAU PET-CT imaging for monitoring the distribution of intravenously administered sr39HSV1-tk gene-transduced CTLs in humans.
Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
Creators: name: Dotti, G.
name: Rooney, C.M.
name: Savoldo, B.
name: Heslop, H.E.
name: Yvon, E.
name: Rossig, C.
name: Mei, Z.
name: Gee, A.P.
name: Pule, M.A.
name: Huls, M.H.
name: Weiss, H.L.
name: Liu, H.
name: Russell, H.V.
name: Myers, G.D.
name: Brenner, M.K.
name: Liu, E.
Publisher: name: Nature Publishing Group
Year: 2008

description: Cytotoxic T lymphocytes (CTLs) directed to nonviral tumor-associated antigens do not survive long term and have limited antitumor activity in vivo, in part because such tumor cells typically lack the appropriate costimulatory molecules. We therefore engineered Epstein-Barr virus (EBV)-specific CTLs to express a chimeric antigen receptor directed to the diasialoganglioside GD2, a nonviral tumor-associated antigen expressed by human neuroblastoma cells. We reasoned that these genetically engineered lymphocytes would receive optimal costimulation after engagement of their native receptors, enhancing survival and antitumor activity mediated through their chimeric receptors. Here we show in individuals with neuroblastoma that EBV-specific CTLs expressing a chimeric GD2-specific receptor indeed survive longer than T cells activated by the CD3-specific antibody OKT3 and expressing the same chimeric receptor but lacking virus specificity. Infusion of these genetically modified cells seemed safe and was associated with tumor regression or necrosis in half of the subjects tested. Hence, virus-specific CTLs can be modified to function as tumor-directed effector cells.
Inducible Caspase 9 Suicide Gene to Improve the Safety of Allodepleted T Cells after Haploidentical Stem Cell Transplantation
Creators: name: Dotti, G.
name: Heslop, H.E.
name: Brenner, M.K.
name: Rooney, C.M.
name: Tey, S.-K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Addback of donor T cells following T cell-depleted stem cell transplantation (SCT) can accelerate immune reconstitution and be effective against relapsed malignancy. After haploidentical SCT, a high risk of graft-versus-host disease (GVHD) essentially precludes this option, unless the T cells are first depleted of alloreactive precursor cells. Even then, the risks of severe GVHD remain significant. To increase the safety of the approach and thereby permit administration of larger T cell doses, we used a suicide gene, inducible caspase 9 (iCasp9), to transduce allodepleted T cells, permitting their destruction should administration have adverse effects. We made a retroviral vector encoding iCasp9 and a selectable marker (truncated CD19). Even after allodepletion (using anti-CD25 immunotoxin), donor T cells could be efficiently transduced, expanded, and subsequently enriched by CD19 immunomagnetic selection to >90% purity. These engineered cells retained antiviral specificity and functionality, and contained a subset with regulatory phenotype and function. Activating iCasp9 with a small-molecule dimerizer rapidly produced >90% apoptosis. Although transgene expression was downregulated in quiescent T cells, iCasp9 remained an efficient suicide gene, as expression was rapidly upregulated in activated (alloreactive) T cells. We have demonstrated the clinical feasibility of this approach after haploidentical transplantation by scaling up production using clinical grade materials.