cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse
Creators: name: Perou, Charles M.
name: He, Xiaping
name: Carey, Lisa
name: Harrell, J. Chuck
name: Prat, Aleix
name: Parker, Joel S.
name: Ewend, Matthew
name: Anders, Carey
name: Fan, Cheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The ability to predict metastatic potential could be of great clinical importance, however, it is uncertain if predicting metastasis to specific vital organs is feasible. As a first step in evaluating metastatic predictions, we analyzed multiple primary tumors and metastasis pairs and determined that >90% of 298 gene expression signatures were found to be similarly expressed between matched pairs of tumors and metastases; therefore, primary tumors may be a good predictor of metastatic propensity. Next, using a dataset of >1,000 human breast tumor gene expression microarrays we determined that HER2-enriched subtype tumors aggressively spread to the liver, while basal-like and claudin-low subtypes colonize the brain and lung. Correspondingly, brain and lung metastasis signatures, along with embryonic stem cell, tumor initiating cell, and hypoxia signatures, were also strongly expressed in the basal-like and claudin-low tumors. Interestingly, low “Differentiation Scores,” or high expression of the aforementioned signatures, further predicted for brain and lung metastases. In total, these data identify that depending upon the organ of relapse, a combination of gene expression signatures most accurately predicts metastatic behavior.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-011-1619-7) contains supplementary material, which is available to authorized users.
Testing Composite Null Hypothesis Based on $S$-Divergences
Creators: name: Ghosh, Abhik
name: Basu, Ayanendranath
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistics Theory (math.ST)
subject: Methodology (stat.ME)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We present a robust test for composite null hypothesis based on the general $S$-divergence family. This requires a non-trivial extension of the results of Ghosh et al.~(2015). We derive the asymptotic and theoretical robustness properties of the resulting test along with the properties of the minimum $S$-divergence estimators under parameter restrictions imposed by the null hypothesis. An illustration in the context of the normal model is also presented.
description: 13 pages
title: ANTOPOL-GOLDMAN LESION: When and how to suspect it
Creators: name: Iturralde-Garriz, Amaya
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Kidney
subject: CT
subject: Ultrasound
subject: Imaging sequences
subject: Structured reporting
subject: Education
subject: Acute
subject: Blood

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: -Describe the Antopol-Goldman lesion and its radiographic findings. -To show the differential diagnosis we must do when we face these radiographic findings. -To expose an infrequent variant of the Antopol Goldman lesion from our hospital with...
Worlds in communities
Creators: name: Galwas, P.A.
Publisher: name: Zenodo
Year: 2023

description: We extend consideration of karma to the realms of digital twins, and then to networks of simulators and surveillance sensors. We show how traditional concepts such as authenticity, provenance, and credibility of information and reliability of sources can all be undermined, leading to interactions that we call “World 4 war”, with humans being out of the loop. The first paper builds on the other three papers to extend Popper’s Worlds 1, 2 & 3 with the concept of a World 4, where autonomous simulations (such as those using machine learning), combine with sensing, for example to generate patterns of life models of individuals. World 4 actuation can influence individuals in scalable and pervasive networks that support replication and feedback, with human control being at best ‘on-the-loop’. This approach can undermine the credibility of information and sources, and the interplay between IT-simulations can give rise to what we call “World 4 war”. The second paper builds context by briefly reviewing the developments of concepts of ‘reality’ and drawing on Popper’s classification of World 1 (physical), World 2 (mental), and World 3 (shared artefacts and beliefs). To demonstrate the approach, we consider examples of biological organisms (World 1); Camus’ viewpoint on human creativity (World 2); and digital processes (World 3). The third paper considers the Buddhist tradition of the Middle Way, which can be seen as bridging Worlds 1 & 2, and which complements Grayings observations of modern thinking on ‘well-supported beliefs’, bridging Worlds 2 & 3 as the basis for shared truths. The MIddle Way requires distinguishing World 1 from World 2, and emphasises the dependent origination of phenomena in both worlds, which necessarily leads to emergence. In this worldview, karma corresponds to humans being in-the-loop, directly influencing origination. Considering high quality data models (HQDM) in this worldview, we note that World 1 admits spatial-temporal extents (STEs), but not abstract entities (such as classifications and relationships). Similarly, DNA-based reproduction exists in World 1, but classification of organisms is clearly in World 2. To bridge Worlds 2 & 3, we draw on Gosden’s triple helix model that gives rise to a spectrum of human participations in the world, bridging the three historical domains of religion, magic and science. The fourth paper explores Worlds in the context of simulations, and formulates a model for digital twins, which are adaptive models in World 3 based on sensing World 1. We observe that stimuli from physical and simulated sources may be indistinguishable and, by considering authenticity and provenance, also that distinguishing stimuli from sentient actors from those from automatons may not be possible. These properties give rise to the new World 4 conception and the possibility of ‘World 4 wars’, with humans being out of the loop.
Improving communication of breast cancer recurrence risk
Creators: name: Richman, Alice R.
name: Carey, Lisa A.
name: DeFrank, Jessica T.
name: Brewer, Noel T.
name: Reyna, Valerie F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Doctors commonly use genomic testing for breast cancer recurrence risk. We sought to assess whether the standard genomic report provided to doctors is a good approach for communicating results to patients.
Processos Participativos na Criação e Desenvolvimento de Comunidades de Aprendizagem
Creators: name: Gomes, Susana P.
Publisher: name: Zenodo
Year: 2022

description: Poster apresentado ao XII Fórum de Jovens Investigadores (FJI) do Instituto de Educação da Universidade de Lisboa, com o objetivo de comunicar e discutir o projeto de investigação em curso no âmbito do Doutoramento em Educação, Formação de Professores e Supervisão.
Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer
Creators: name: Lips, Esther H.
name: Mukhtar, Rita A.
name: Van'T Veer, Laura J.
name: Carey, Lisa A.
name: Livasy, Chad
name: Loo, Claudette E.
name: Sonke, Gabe S.
name: Rodenhuis, Sjoerd
name: De Ronde, Jorma J.
name: Yau, Christina
name: Shelley Hwang, E.
name: Esserman, Laura J.
name: Wesseling, Jelle
name: Berry, Donald A.
name: Vrancken-Peeters, Marie Jeanne T.F.D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Invasive lobular carcinoma (ILC) has been reported to be less responsive to neoadjuvant chemotherapy (NAC) than invasive ductal carcinoma (IDC). We sought to determine whether ILC histology indeed predicts poor response to NAC by analyzing tumor characteristics such as protein expression, gene expression, and imaging features, and by comparing NAC response rates to those seen in IDC after adjustment for these factors. We combined datasets from two large prospective NAC trials, including in total 676 patients, of which 75 were of lobular histology. Eligible patients had tumors ≥ 3 cm in diameter or pathologic documentation of positive nodes, and underwent serial biopsies, expression microarray analysis, and MRI imaging. We compared pathologic complete response (pCR) rates and breast conservation surgery (BCS) rates between ILC and IDC, adjusted for clinicopathologic factors. On univariate analysis, ILCs were significantly less likely to have a pCR after NAC than IDCs (11% vs. 25%, p=0.01). However, the known differences in tumor characteristics between the two histologic types, including hormone-receptor (HR) status, Her2 status, histological grade, and p53 expression, accounted for this difference with the lowest pCR rates among HR+/Her2- tumors in both ILC and IDC (7% and 5%, respectively). ILC which were HR- and/or Her2+ had a pCR rate of 25%. Expression subtyping, particularly the NKI 70-gene signature, was correlated with pCR, although the small numbers of ILC in each group precluded significant associations. BCS rate did not differ between IDC and ILC after adjusting for molecular characteristics. We conclude that ILC represents a heterogeneous group of tumors which are less responsive to NAC than IDC. However, this difference is explained by differences in molecular characteristics, particularly HR and Her2, and independent of lobular histology.
Barjols, entrée des tambourinaires sur la place de la Rouguière pour l'ouverture des fêtes provençales
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Barjols, place de la Rouguière, rigodon dansé par Lei Tambourinaire de Sant Sumian
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Locally advanced breast cancers are more likely to present as Interval Cancers: results from the I-SPY 1 TRIAL (CALGB 150007/150012, ACRIN 6657, InterSPORE Trial)
Creators: name: Lehman, Constance
name: Moore, Dan
name: Esserman, Laura J.
name: Berry, Donald
name: Liu, Minetta
name: Buxton, Meredith Becker
name: Tripathy, Debasish
name: Krontiras, Helen
name: Lin, Cheryl
name: De Michele, Angela
name: Montgomery, Leslie
name: Yau, Christina
name: Carey, Lisa
name: Olapade, Olufunmilayo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Interval cancers (ICs), defined as cancers detected between regular screening mammograms, have been shown to be of higher grade, larger size, and associated with lower survival, compared with screen-detected cancers (SDCs) and comprise 17% of cancers from population-based screening programs. We sought to determine the frequency of ICs in a study of locally advanced breast cancers, the I-SPY 1 TRIAL. Screening was defined as having a mammogram with 2 years, and the proportion of ICs at 1 and 2 years was calculated for screened patients. Differences in clinical characteristics for ICs versus SDCs and screened versus non-screened cancers were assessed. For the 219 evaluable women, mean tumor size was 6.8 cm. Overall, 80% of women were over 40 and eligible for screening; however, only 31% were getting screened. Among women screened, 85% were ICs, with 68% diagnosed within 1 year of a previously normal mammogram. ICs were of higher grade (49% vs. 10%) than SDCs. Among non-screened women, 28% (43/152) were younger than the recommended screening age of 40. Of the entire cohort, 12% of cancers were mammographically occult (MO); the frequency of MO cancers did not differ between screened (11%) and non-screened (15%). ICs were common in the I-SPY 1 TRIAL suggesting the potential need for new approaches beyond traditional screening to reduce mortality in women who present with larger palpable cancers.
Mammographic density and breast cancer risk in White and African American Women
Creators: name: Gierach, Gretchen L.
name: Olshan, Andrew F.
name: Millikan, Robert C.
name: Razzaghi, Hilda
name: Troester, Melissa A.
name: Yankaskas, Bonnie C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Mammographic density is a strong risk factor for breast cancer, but limited data are available in African American (AA) women. We examined the association between mammographic density and breast cancer risk in AA and white women. Cases (n = 491) and controls (n = 528) were from the Carolina Breast Cancer Study (CBCS) who also had mammograms recorded in the Carolina Mammography Registry (CMR). Mammographic density was reported to CMR using Breast Imaging Reporting and Data System (BI-RADS) categories. Increasing mammographic density was associated with increased breast cancer risk among all women. After adjusting for potential confounders, a monotonically increasing risk of breast cancer was observed between the highest versus the lowest BI-RADS density categories [OR = 2.45, (95 % confidence interval: 0.99, 6.09)]. The association was stronger in whites, with ~40 % higher risk among those with extremely dense breasts compared to those with scattered fibroglandular densities [1.39, (0.75, 2.55)]. In AA women, the same comparison suggested lower risk [0.75, (0.30, 1.91)]. Because age, obesity, and exogenous hormones have strong associations with breast cancer risk, mammographic density, and race in the CBCS, effect measure modification by these factors was considered. Consistent with previous literature, density-associated risk was greatest among those with BMI > 30 and current hormone users (P value = 0.02 and 0.01, respectively). In the CBCS, mammographic density is associated with increased breast cancer risk, with some suggestion of effect measure modification by race, although results were not statistically significant. However, exposures such as BMI and hormone therapy may be important modifiers of this association and merit further investigation.
On the formation of shocks of electromagnetic plane waves in non-linear crystals
Creators: name: Christodoulou, Demetrios
name: Perez, Daniel Raoul
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Optics (physics.optics)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35L67 (Primary) 35L60, 35L50, 78A60 (Secondary)

description: An influential result of F. John states that no genuinely non-linear strictly hyperbolic quasi-linear first order system of partial differential equations in two variables has a global $C^2$-solution for small enough initial data. Inspired by recent work of D. Christodoulou, we revisit John's original proof and extract a more precise description of the behaviour of solutions at the time of shock. We show that John's singular first order quantity, when expressed in characteristic coordinates, remains bounded until the final time, which is then characterised by an inverse density of characteristics tending to zero in one point. Moreover, we study the derivatives of second order, showing again their boundedness when expressed in appropriate coordinates. We also recover John's upper bound for the time of shock formation and complement it with a lower bound. Finally, we apply these results to electromagnetic plane waves in a crystal with no magnetic properties and cubic electric non-linearity in the energy density, assuming no dispersion.
description: 54 pages, no figures
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
Creators: name: Bigelow, Carol
name: Joseph Jerry, D.
name: Smith Schneider, Sallie
name: Sun, Xuezheng
name: Troester, Melissa A.
name: Casbas-Hernandez, Patricia
name: Makowski, Liza
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have seldom been studied in association with obesity.
Barjols, place de la Rouguière, montagnarde dansée par le groupe folklorique toulonnais Escolo de la Targo
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
title: A Novel Method for Grounding in Answer-Set Programming
Creators: name: Besin, Viktor
Publisher: name: TU Wien
Year: 2023
Subjects: subject: Algorithms
subject: Answer Set Programming
subject: Epistemic Logic Programming
subject: Computational Complexity
subject: Grounding
subject: Knowledge Representation and Reasoning

description: Answer-set programming (ASP) is a declarative programming paradigm that has gained widespread popularity together with many extensions for solving a variety of problems in artificial intelligence, especially in the field of knowledge representation and reasoning. One of the key challenges in ASP is the process of grounding, which involves transforming a high-level problem specification into a set of low-level logical rules by replacing variables with constants. Grounding is crucial for the overall performance of ASP systems, as it directly affects the size and complexity of the resulting rule set, and for certain problems results in the well-known ASP grounding bottleneck, where the ground program is too huge to be processed by the ASP solver. In this thesis, we present a novel method for grounding in ASP which decouples non-ground atoms in rules in order to delegate the evaluation of rule bodies to the solving process. To this end, we present translations from non-ground, normal (tight) programs to ground, disjunctive programs as well as non-ground, disjunctive to ground epistemic logic programs. In comparison to traditional grounding systems, our translations yield programs that are exponential only in the maximum predicate arity, and thus polynomial if this arity is bounded by a constant. With the implementation of a prototype, we demonstrate technical feasibility of this new method and compare to state-of-the-art ASP technology in terms of grounding size, grounding time and total runtime. It turns out that our approach is competitive with existing systems.
Supplementary methods from Relation between travel strategy and social organization of migrating birds with special consideration of formation flight in the northern bald ibis
Creators: name: B. Voelkl
name: J. Fritz
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: A considerable proportion of the world's bird species undertake seasonal long-distance migrations. These journeys are energetically demanding. Two major behavioural means to reduce energy expenditure have been suggested: the use of thermal uplifts for a soaring-gliding migration style and travelling in echelon or V-shaped formation. Both strategies have immediate consequences for the social organization of the birds as they either cause large aggregations or require travelling in small and stable groups. Here, we first discuss those consequences, and second present an analysis of formation flight in a flock of northern bald ibis on their first southbound migration. We observe clear correlations between leading and trailing on the dyadic level but only a weak correlation on the individual level during independent flight and no convincing correlation during the human guided part of the migration. This pattern is suggestive of direct reciprocation as a means for establishing cooperation during formation flight. In general, we conclude that behavioural adaptations for dealing with physiological constraints on long-distance migrations either necessitate or ultimately foster formation of social groups with different characteristics. Patterns and social organization of birds travelling in groups have been elusive to study; however, new tracking technology—foremost lightweight GPS units—will provide more insights in the near future.This article is part of the themed issue ‘Physiological determinants of social behaviour in animals’.
Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures
Creators: name: Kline, Enos
name: Sartorius, Carol A.
name: Wisell, Joshua
name: Edgerton, Susan M.
name: Harrell, J. Chuck
name: Finlay-Schultz, Jessica
name: Elias, Anthony
name: Kabos, Peter
name: Li, Chunling
name: Manuel, Christopher A.
name: Finlayson, Christina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Bypassing estrogen receptor (ER) signaling during development of endocrine resistance remains the most common cause of disease progression and mortality in breast cancer patients. To date, the majority of molecular research on ER action in breast cancer has occurred in cell line models derived from late stage disease. Here we describe patient-derived ER + luminal breast tumor models for the study of intratumoral hormone and receptor action. Human breast tumor samples obtained from patients post surgery were immediately transplanted into NOD/SCID or NOD/SCID/ILIIrg−/− mice under estrogen supplementation. Five transplantable patient-derived ER + breast cancer xenografts were established, derived from both primary and metastatic cases. These were assessed for estrogen dependency, steroid receptor expression, cancer stem cell content, and endocrine therapy response. Gene expression patterns were determined in select tumors ±estrogen and ±endocrine therapy. Xenografts morphologically resembled the patient tumors of origin, and expressed similar levels of ER (5–99 %), and progesterone and androgen receptors, over multiple passages. Four of the tumor xenografts were estrogen dependent, and tamoxifen or estrogen withdrawal (EWD) treatment abrogated estrogen-dependent growth and/or tumor morphology. Analysis of the ER transcriptome in select tumors revealed notable differences in ER mechanism of action, and downstream activated signaling networks, in addition to identifying a small set of common estrogen-regulated genes. Treatment of a na¨ıve tumor with tamoxifen or EWD showed similar phenotypic responses, but relatively few similarities in estrogen-dependent transcription, and affected signaling pathways. Several core estrogen centric genes were shared with traditional cell line models. However, novel tumor-specific estrogen-regulated potential target genes, such as cancer/testis antigen 45, were uncovered. These results evoke the importance of mapping both conserved and tumor-unique ER programs in breast cancers. Furthermore, they underscore the importance of primary xenografts for improved understanding of ER+ breast cancer heterogeneity and development of personalized therapies.
Melting Hadrons, Boiling Quarks
Creators: name: Rafelski, Johann
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: In the context of the Hagedorn temperature half-centenary I describe our understanding of the hot phases of hadronic matter both below and above the Hagedorn temperature. The first part of the review addresses many frequently posed questions about properties of hadronic matter in different phases, phase transition and the exploration of quark-gluon plasma (QGP). The historical context of the discovery of QGP is shown and the role of strangeness and strange antibaryon signature of QGP illustrated. In the second part I discuss the corresponding theoretical ideas and show how experimental results can be used to describe the properties of QGP at hadronization. The material of this review is complemented by two early and unpublished reports containing the prediction of the different forms of hadron matter, and of the formation of QGP in relativistic heavy ion collisions, including the discussion of strangeness, and in particular strange antibaryon signature of QGP.
description: Review with both scientific and historical contents: 84 EPJ pages, v2 in press at EPJ-A; the two appendices will be published as citable separate items
Predictors of timing of adjuvant chemotherapy in older women with hormone receptor–negative, stages II–III breast cancer
Creators: name: Peppercorn, Jeffrey
name: Wheeler, Stephanie B.
name: Carpenter, William R.
name: Weinberger, Morris
name: Schenck, Anna P.
name: Biddle, Andrea K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Adherence to consensus guidelines for cancer care may vary widely across health care settings and contribute to differences in cancer outcomes. For some women with breast cancer, omission of adjuvant chemotherapy or delays in its initiation may contribute to differences in cancer recurrence and mortality. We studied adjuvant chemotherapy use among women with stage II or stage III, hormone receptor–negative breast cancer to understand health system and socio-demographic correlates of under-use and delayed adjuvant chemotherapy. We used Surveillance Epidemiology and End Results (SEER)-Medicare linked data to examine the patterns of care for 6,678 women aged 65 and older diagnosed with stage II or stage III hormone receptor–negative breast cancer in 1994–2002, with claims data through 2007. Age-stratified logistic regression was employed to examine the potential role of socio-demographic and structural/organizational health services characteristics in explaining differences in adjuvant chemotherapy initiation. Overall utilization of guideline-recommended adjuvant chemotherapy peaked at 43% in this population. Increasing age, higher co-morbidity burden, and low-income status were associated with lower odds of chemotherapy initiation within 4 months, whereas having positive lymph nodes, more advanced disease, and being married were associated with higher odds (P < 0.05). Health system–related structural/organizational characteristics and race/ethnicity offered little explanatory insight. Timely initiation of guideline-recommended adjuvant chemotherapy was low, with significant variation by age, income, and co-morbidity status. Based on these findings, future studies should seek to explore the more nuanced reasons why older women do not receive chemotherapy and why delays in care occur.
The Shared and Unique Effects of Structural Stigma and Interpersonal Discrimination on Internalized Stigma and Self-Hate: A Commonality Analysis
Creators: name: Zeng, Katherine
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Clinical Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Discrimination
subject: Internalized stigma
subject: SGM
subject: Self-hate
subject: Structural stigma

description: Honors Project
D1.3 Report on policies, policy-making processes, and governance for multi- hazard, multi-risk management
Creators: name: Schlumberger, Julius
name: Stuparu, Dana
name: Ciurean, Roxana L.
name: Duncan, Melanie
name: Mysiak, Jaroslav
name: Khazai, Bijan
name: Rimmer, Jemma
name: Dochiu, Corina
name: Claassen, Judith
name: Warren, Andrew
Publisher: name: Zenodo
Year: 2023
Subjects: Multi-risk
Governance
Multi-Sector Dynamics
Science-Policy Interaction

description: MYRIAD-EU has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003276.
Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients
Creators: name: Wang, Qiao
name: Gonzalez, Karina
name: Xu, Xinran
name: Chen, Jia
name: Gammon, Marilie D.
name: Garbowski, Gail
name: Hibshoosh, Hanina
name: Zhang, Yu Jing
name: Neugut, Alfred I.
name: Shen, Jing
name: Santella, Regina M.
name: Teitelbaum, Susan L.
name: Cho, Yoon Hee
name: Bradshaw, Patrick T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The association between promoter methylation status and survival was investigated in a large cohort of women with breast cancer, participants in the Long Island Breast Cancer Study Project. Archived tumor tissues (n=839) were collected from women diagnosed with a first primary invasive or in situ breast cancer in 1996-1997. Vital status was followed through the end of 2005 with a mean follow up time of 8 years. Promoter methylation of 8 breast cancer-related genes was assessed by MethyLight. The frequencies of methylation for HIN1, RASSF1A, DAPK1, GSTP1, CyclinD2, TWIST, CDH1 and RARβ were 62.9%, 85.2%, 14.1%, 27.8%, 19.6%, 15.3%, 5.8% and 27.6%, respectively. Since survival rates of in situ and invasive breast cancers are substantially different, survival analyses were conducted within 670 invasive cases with complete data on all genes. Age-adjusted Cox-proportional hazards models revealed that GSTP1, TWIST and RARβ methylation was significantly associated with higher breast cancer-specific mortality. Methylation of GSTP1 and RARβ were significantly associated with higher all-cause mortality. To investigate the relationship between the number of methylated genes and breast cancer-specific mortality, we included previously published MethyLight data on p16 and APC methylation status. Breast cancer-specific mortality increased in a dose-dependent manner with increasing number of methylated genes (Ptrend = 0.002), although confidence intervals were wide. Our results suggest that promoter methylation, particularly for a panel of genes, has the potential to be used as a biomarker for predicting prognosis in breast cancer.
Structural/organizational characteristics of health services partly explain racial variation in timeliness of radiation therapy among elderly breast cancer patients
Creators: name: Peppercorn, Jeffrey
name: Schenck, Anna P.
name: Carpenter, William R.
name: Weinberger, Morris
name: Biddle, Andrea K.
name: Wheeler, Stephanie B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Observed racial/ethnic disparities in the process and outcomes of breast cancer care may be explained, in part, by structural/organizational characteristics of health care systems. We examined the role of surgical facility characteristics and distance to care in explaining racial/ethnic variation in timing of initiation of guideline-recommended radiation therapy (RT) after breast conserving surgery (BCS). We used Surveillance Epidemiology and End Results-Medicare data to identify women ages 65 and older diagnosed with stages I–III breast cancer and treated with BCS in 1994–2002. We used stepwise multivariate logistic regression to examine the interactive effects of race/ethnicity and facility profit status, teaching status, size, and institutional affiliations, and distance to nearest RT on timing of RT initiation, controlling for known covariates. Among 38,574 eligible women who received BCS, 39% received RT within 2 months, 52% received RT within 6 months, and 57% received RT within 12 months post-diagnosis, with significant variation by race/ethnicity. In multivariate models, women attending smaller surgical facilities and those with on-site radiation had higher odds of RT at each time interval, and women attending governmental facilities had lower odds of RT at each time interval (P < 0.05). Increasing distance between patients’ residence and nearest RT provider was associated with lower overall odds of RT, particularly among Hispanic women (P < 0.05). In fully adjusted models including race-by-distance interaction terms, racial/ethnic disparities disappeared in RT initiation within 6 and 12 months. Racial/ethnic disparities in timing of RT for breast cancer can be partially explained by structural/organizational health system characteristics. Identifying modifiable system-level factors associated with quality cancer care may help us target policy interventions that can reduce disparities in outcomes.
A triple origin for the lack of tight coplanar circumbinary planets around short-period binaries
Creators: name: Hamers, Adrian S.
name: Perets, Hagai B.
name: Zwart, Simon F. Portegies
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Transiting circumbinary planets are more easily detected around short-period than long-period binaries, but none have yet been observed by {\it Kepler} orbiting binaries with periods shorter than seven days. In triple systems, secular Kozai-Lidov cycles and tidal friction (KLCTF) have been shown to reduce the inner orbital period from $\sim 10^4$ to a few days. Indeed, the majority of short-period binaries are observed to possess a third stellar companion. Using secular evolution analysis and population synthesis, we show that KLCTF makes it unlikely for circumbinary transiting planets to exist around short-period binaries. We find the following outcomes. (1) Sufficiently massive planets in tight and/or coplanar orbits around the inner binary can quench the KL evolution because they induce precession in the inner binary. The KLCTF process does not take place, preventing the formation of a short-period binary. (2) Secular evolution is not quenched and it drives the planetary orbit into a high eccentricity, giving rise to an unstable configuration, in which the planet is most likely ejected from the system. (3) Secular evolution is not quenched but the planet survives the KLCTF evolution. Its orbit is likely to be much wider than the currently observed inner binary orbit, and is likely to be eccentric and inclined with respect to the inner binary. These outcomes lead to two main conclusions: (1) it is unlikely to find a massive planet on a tight and coplanar orbit around a short-period binary, and (2) the properties of circumbinary planets in short-period binaries are constrained by secular evolution.
description: Revised to match MNRAS publication. 24 pages, 22 figures
D1.3 Report on policies, policy-making processes, and governance for multi- hazard, multi-risk management
Creators: name: Schlumberger, Julius
name: Stuparu, Dana
name: Ciurean, Roxana L.
name: Duncan, Melanie
name: Mysiak, Jaroslav
name: Khazai, Bijan
name: Rimmer, Jemma
name: Dochiu, Corina
name: Claassen, Judith
Publisher: name: Zenodo
Year: 2022
Subjects: Multi-risk
Governance
Multi-Sector Dynamics
Science-Policy Interaction

description: MYRIAD-EU has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003276.
Surface electronic structure and evidence of plain s-wave superconductivity in (Li0.8Fe0.2)OHFeSe
Creators: name: Yan, Y. J.
name: Zhang, W. H.
name: Ren, M. Q.
name: Liu, X.
name: Lu, X. F.
name: Wang, N. Z.
name: Niu, X. H.
name: Fan, Q.
name: Miao, J.
name: Tao, R.
name: Xie, B. P.
name: Chen, X. H.
name: Zhang, T.
name: Feng, D. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: (Li0.8Fe0.2)OHFeSe is a newly-discovered intercalated iron-selenide superconductor with a Tc above 40 K, which is much higher than the Tc of bulk FeSe (8 K). Here we report a systematic study of (Li0.8Fe0.2)OHFeSe by low temperature scanning tunneling microscopy (STM). We observed two kinds of surface terminations, namely FeSe and (Li0.8Fe0.2)OH surfaces. On the FeSe surface, the superconducting state is fully gapped with double coherence peaks, and a vortex core state with split peaks near EF is observed. Through quasi-particle interference (QPI) measurements, we clearly observed intra- and inter-pocket scatterings in between the electron pockets at the M point, as well as some evidence of scattering that connects gamma and M points. Upon applying magnetic field, the QPI intensity of all the scattering channels are found to behave similarly. Furthermore, we studied impurity effects on the superconductivity by investigating intentionally introduced impurities and intrinsic defects. We observed that magnetic impurities such as Cr adatoms can induce in-gap states and suppress superconductivity. However, nonmagnetic impurities such as Zn adatoms do not induce visible in-gap states. Meanwhile, we show that Zn adatoms can induce in-gap states in thick FeSe films, which is believed to have an (s+-)wave pairing symmetry. Our experimental results suggest it is likely that (Li0.8Fe0.2)OHFeSe is a plain s-wave superconductor, whose order parameter has the same sign on all Fermi surface sections.
description: 18 pages, 9 figures, supplementary information included
The Piper Fatigue Scale-12 (PFS-12): psychometric findings and item reduction in a cohort of breast cancer survivors
Creators: name: Alfano, Catherine M.
name: Baumgartner, Kathy B.
name: Ballard-Barbash, Rachel
name: Smith, Ashley Wilder
name: Reeve, Bryce B.
name: Stover, Angela M.
name: Piper, Barbara F.
name: Bernstein, Leslie
name: McTiernan, Anne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Brief, valid measures of fatigue, a prevalent and distressing cancer symptom, are needed for use in research. This study’s primary aim was to create a shortened version of the revised Piper Fatigue Scale (PFS-R) based on data from a diverse cohort of breast cancer survivors. A secondary aim was to determine whether the PFS captured multiple distinct aspects of fatigue (a multidimensional model) or a single overall fatigue factor (a unidimensional model).
T-duality Twists and Asymmetric Orbifolds
Creators: name: Tan, H. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study some aspects of asymmetric orbifolds of tori, with the orbifold group being some $\mathbb{Z}_N$ subgroup of the T-duality group and, in particular, provide a concrete understanding of certain phase factors that may accompany the T-duality operation on the stringy Hilbert space in toroidal compactification. We discuss how these T-duality twist phase factors are related to the symmetry and locality properties of the closed string vertex operator algebra, and clarify the role that they enact in the modular covariance of the orbifold theory, mainly using asymmetric orbifolds of tori which are root lattices as working examples.
description: 67 pages. v2: references added and typos corrected
Obtención de biogás y biol como fuente de energía renovable de biodigestores experimentales en la UTC  extensión La Maná
Creators: name: William Armando, Hidalgo Osorio
name: Paco Jovanni, Vasquez Carrera
name: Johnatan Israel, Corrales Bonilla
name: Monserrath Carolina, Vásquez Rodríguez
Publisher: name: Zenodo
Year: 2023

description: El presente proyecto tiene dos objetivos principales. El primero de ellos, diseñar, construir y
poner en funcionamiento un biodigestor tubular de bolsa; y el segundo, con fines didácticos,
dejar constancia de todo el proceso de construcción y generación de BIOGÁS, para que los
estudiantes de la Universidad Técnica De Cotopaxi Extensión La Maná, implementen el
biodigestor y lo tomen como punto de partida para futuras investigaciones. Un requisito
imprescindible, era la construcción del mismo con materiales locales y utilizando, los recursos tanto técnicos como económicos, con los que contaría un estudiante de la UTC
extensión La Maná. El propósito obtener biogás y utilizarla como fuente de energía a través
de esta tecnología. De este modo, se desarrolló y se puso en funcionamiento un biodigestor,
que requiere una baja inversión de capital, con materiales adquiridos en la región, sin
complejidad técnica y que el beneficiario pueda reproducir, controlar y mantener, haciéndola
parte de su vida cotidiana. Además del proceso constructivo, se llevaron a cabo, diferentes
experimentos y toma de datos, en los laboratorios de la Universidad Técnica De Cotopaxi
Extensión La Maná y en las inmediaciones del biodigestor, con el objetivo de conseguir la
máxima eficiencia en la etapa inicial de producción de gas y de aportar datos empíricos
recogidos durante el proceso de digestión. A demás del aprovechamiento del potencial
energético de la materia orgánica para obtener biogás a través de un biodigestor se obtiene
BIOL como desecho el cual es un fertilizante que aportara en el desarrollo agrícola del sector.
Palabras claves: Eficiencia, Potencial Energético, Fines didácticos.
title: Sü ile çare. Υδροθεραπευτήριο και ξενοδοχειακή μονάδα στην ιαματική πηγή Ευθαλούς Λέσβου

title: Healing Waters. Hydrotherapy center and hotel complex around the thermal spring of Euthalou, Lesvos
Creators: name: Αποστολη Χριστινα-Στυλιανη
name: Σαλαλιδου Αναστασια
Publisher: name: Technical University of Crete
Year: 2020

description: Το κέντρο θερμαλισμού επικάθεται στη βραχώδη πλαγιά, στη βάση της οποίας     βρίσκεται η ιαματική πηγή της Ευθαλούς και η ομώνυμη παραλία. Βασική αρχιτεκτονική πρόθεση είναι η ένωση βουνού και θάλασσας για την ενίσχυση της φυσικής θέσης της πηγής στην περιοχή. Πηγή έμπνευσης αποτελεί η τοπική μέθοδος διαχείρισης απότομων πλαγιών των αγροτών της Λέσβου, τα σέτια - αναβαθμοί. Το συγκρότημα αποτελείται από λουτρά σε ένα σύστημα εναλλακτικών μεθόδων θεραπείας και χρήσεων που τα συνοδεύουν, γύρω από την ιαματική πηγή και πάνω στην παραλία. Το ξενοδοχειακό συγκρότημα, ιδιωτικά καταλύματα σε διάταξη ‘χωριού’  που αναρριχώνται στην πλαγιά και οργανώνονται σε επίπεδα, συμπληρώνει και υποστηρίζει τις προαναφερθείσες λειτουργίες. Οι βασικοί κυβικοί όγκοι των κτηρίων με τους σφηνοειδής ενδιάμεσους χώρους τοποθετούνται ακολουθώντας το φυσικό ανάγλυφο του εδάφους, ενώ με τα μεγάλα ανοίγματα που έχουν θέα προς τη θάλασσα και την άμεση επαφή με τον βράχο επιτυγχάνουν την ένωση των δύο φυσικών στοιχείων και στο εσωτερικό τους.
Device-to-Device Millimeter Wave Communications: Interference, Coverage, Rate, and Finite Topologies
Creators: name: Venugopal, Kiran
name: Valenti, Matthew C.
name: Heath, Robert W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Emerging applications involving device-to-device communication among wearable electronics require Gbps throughput, which can be achieved by utilizing millimeter wave (mmWave) frequency bands. When many such communicating devices are indoors in close proximity, like in a train car or airplane cabin, interference can be a serious impairment. This paper uses stochastic geometry to analyze the performance of mmWave networks with a finite number of interferers in a finite network region. Prior work considered either lower carrier frequencies with different antenna and channel assumptions, or a network with an infinite spatial extent. In this paper, human users not only carry potentially interfering devices, but also act to block interfering signals. Using a sequence of simplifying assumptions, accurate expressions for coverage and rate are developed that capture the effects of key antenna characteristics like directivity and gain, and are a function of the finite area and number of users. The assumptions are validated through a combination of analysis and simulation. The main conclusions are that mmWave frequencies can provide Gbps throughput even with omni-directional transceiver antennas, and larger, more directive antenna arrays give better system performance.
description: 32 pages, 17 figures, Submitted to IEEE Transactions on Wireless Communications
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes
Creators: name: Adamo, Barbara
name: Troester, Melissa
name: Roman, Erick
name: Bixby, Lisa
name: Karginova, Olga
name: Fan, Cheng
name: Prat, Aleix
name: Perou, Charles M.
name: Harrell, J. Chuck
name: He, Xiaping
name: Parker, Joel S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Five molecular subtypes (luminal A, luminal B, HER2-enriched, basal-like, and claudin-low) with clinical implications exist in breast cancer. Here, we evaluated the molecular and phenotypic relationships of (1) a large in vitro panel of human breast cancer cell lines (BCCLs), human mammary fibroblasts (HMFs), and human mammary epithelial cells (HMECs); (2) in vivo breast tumors; (3) normal breast cell subpopulations; (4) human embryonic stem cells (hESCs); and (5) bone marrow-derived mesenchymal stem cells (hMSC). First, by integrating genomic data of 337 breast tumor samples with 93 cell lines we were able to identify all the intrinsic tumor subtypes in the cell lines, except for luminal A. Secondly, we observed that the cell lines recapitulate the differentiation hierarchy detected in the normal mammary gland, with claudin-low BCCLs and HMFs cells showing a stromal phenotype, HMECs showing a mammary stem cell/bipotent progenitor phenotype, basal-like cells showing a luminal progenitor phenotype, and luminal B cell lines showing a mature luminal phenotype. Thirdly, we identified basal-like and highly migratory claudin-low subpopulations of cells within a subset of triple-negative BCCLs (SUM149PT, HCC1143, and HCC38). Interestingly, both subpopulations within SUM149PT were enriched for tumor-initiating cells, but the basal-like subpopulation grew tumors faster than the claudin-low subpopulation. Finally, claudin-low BCCLs resembled the phenotype of hMSCs, whereas hESCs cells showed an epithelial phenotype without basal or luminal differentiation. The results presented here help to improve our understanding of the wide range of breast cancer cell line models through the appropriate pairing of cell lines with relevant in vivo tumor and normal cell counterparts.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-013-2743-3) contains supplementary material, which is available to authorized users.
On the complexity of the chip-firing reachability problem
Creators: name: Hujter, Bálint
name: Kiss, Viktor
name: Tóthmérész, Lilla
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C57, 05C50, 68Q25

description: In this paper, we study the complexity of the chip-firing reachability problem. We show that for Eulerian digraphs, the reachability problem can be decided in strongly polynomial time, even if the digraph has multiple edges. We also show a special case when the reachability problem can be decided in polynomial time for general digraphs: if the target distribution is recurrent restricted to each strongly connected component. As a further positive result, we show that the chip-firing reachability problem is in co-NP for general digraphs. We also show that the chip-firing halting problem is in co-NP for Eulerian digraphs.