cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Connexin expression, connexin-mediated communication, and the effect of connexin overexpression in an in vitro model of human neuronal differentiation.
Creators: name: Boucher, Sherri Elizabeth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Biology, Neuroscience.

description: The connexin (Cx) family of transmembrane proteins oligomerize to form hemichannels, permitting communication with the extracellular environment, and gap junctions, forming the basis for intercellular communication between adjacent cells. Although hemichannel communication remains unexplored, it is well established that gap junction intercellular communication is maximal in the developing central nervous system prior to formation of functional chemical synapses. The NT2/D1 (NT2) in vitro system, which can be terminally differentiated to hNT cultures containing human central nervous system neurons, was used as a starting point to further our understanding of the functional significance of Cx proteins and Cx-mediated communication in influencing neural progenitor fate. In Chapter 1, several Cxs, typically expressed by the mammalian central nervous system, were analyzed for expression in NT2 and hNT cultures. Cx30, Cx36, Cx37, and Cx43 were detected in undifferentiated NT2 cultures. Cx36, Cx43, and Cx46.6 were detected in all hNT cultures tested while Cx30 and Cx37 were detected in only a subset of hNT cultures. In Chapter 3, fluorescent dye transfer assays validated previous reports of decreased gap junction intercellular communication in hNT cultures compared to NT2 cultures. A series of dye uptake assays revealed inducible hemichannel activity in NT2s but not hNTs suggesting that like gap junction intercellular communication, hemichannel activity decreases following terminal neuronal differentiation. This marks the first report of hemichannel activity in neural progenitors. In Chapter 4, the specific role of Cx32 in neuronal differentiation was addressed through transfection of NT2s with Cx32. Cx32 expression blocked terminal neuronal differentiation without affecting oligodendrocyte differentiation as determined by lineage analysis of NT2s and hNTs. We propose a model where Cx32 expression by neural progenitors prevents differentiation to neurons and promotes differentiation to oligodendrocytes in NT2 cell through activation of hemichannels.
3364822.pdf
Creators: name: Li, Kwai Hei
name: Fu, Wai Yuen
name: Cheung, Yuk
name: Wong, Kenneth Kin-Yip
name: wang, yongjin
name: Lau, Kei May
name: Choi, H.
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplementary Document
HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study
Creators: name: Harris, Marianne
name: Ganase, Bruce
name: Watson, Birgit
name: Harrigan, Paul Richard
name: Montaner, Julio
name: Hull, Mark W.
Publisher: name: BioMed Central
Year: 2017

description: Background: As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) with darunavir. Methods: A single arm, open-label 48-week study was conducted of regimen simplification to E/C/F/TDF plus darunavir 800 mg daily from stable therapy including two nucleoside/nucleotide reverse transcriptase inhibitors, a ritonavir-boosted protease inhibitor, and an integrase inhibitor. Participants had plasma HIV viral load consistently < 200 copies/mL for ≥ 6 months, estimated glomerular filtration rate (eGFR) ≥ 60 mL/min, and no genotypic resistance to major components of the study regimen. Plasma viral load was measured at weeks 2 and 4, then every 4 weeks throughout the study. Safety laboratory assessments were conducted at baseline and at weeks 12, 24, 36, and 48. Antiretroviral drug concentrations were measured at baseline and once ≥ 2 weeks after the regimen change. Results: Ten HIV-infected adults (8 male and 2 female; median age 50.5 years) were enrolled. All maintained virologic suppression on the new regimen for 48 weeks. One subject experienced a decrease in eGFR from 62 mL/min at baseline to 52 mL/min at week 12; study medications were continued and his eGFR remained stable (50–59 mL/min) thereafter. No subjects discontinued study medications for renal function changes or other adverse events. Darunavir trough concentration were lower on the new regimen than on darunavir/ritonavir 800/100 mg (n = 5; p < 0.05). Conclusions: Despite low darunavir trough concentrations, treatment simplification to a two-pill, once-daily regimen of E/C/F/TDF plus darunavir was safe and effective for 48 weeks among 10 selected treatment-experienced HIV-infected patients. Trial registration The study protocol was registered with ClinicalTrials.gov (NCT02199613) on July 22, 2014
D1.3: Degradation Mechanisms in Automotive Fuel Cell Systems
Creators: name: Penga, Željko
name: Radica, Gojmir
name: Barbir, Frano
name: Eckert, Peter
Publisher: name: Zenodo
Year: 2017
Subjects: PEM fuel cell stack and balance-of-plant
degradation mechanisms
accelerated stress test

description: Degradation mechanisms in automotive PEM fuel cell systems are categorized, in this deliverable, in regard to the degradation mechanisms of each component of PEM fuel cell stack, namely: membrane, catalyst layers, gas diffusion layers, bipolar plates and sealing gaskets. The underlying degradation mechanisms of each of the aforementioned structural component of the cell are decomposed with brief explanation of the physical phenomena causing the degradation and the inter-relation of the influence of one constituent of the structural component on the other. The analysis based on available data from the project partners and literature survey leads to the conclusion that the main degradation mechanisms of the cell depend on high number of different variables, such as MEA manufacturing process, assembly, operating conditions, thermal cycling, relative humidity cycling, subfreezing ambient temperature, load cycling, etc. Therefore, the main degradation mechanisms have to be determined based on the particular and highly detailed cell configuration. The mitigation strategies are proposed for each structural component, although some of the requirements may be in confrontation with each other. PEM fuel cell degradation cannot be completely suppressed, however by closely monitoring the cell operation and adapting the operating conditions to the particular cell design, they can be significantly minimized. The accelerated stress tests are surveyed and listed for each structural component, and some of them are compared vs. real-time investigation under certain operating conditions (e.g. carbon corrosion) with good agreement. General conclusion is that the ability of Degradation Mechanisms in Automotive Fuel Cell Systems Page 2 of 46 the accelerated stress tests to predict the real-time operating conditions inside the cell is of a limited reliability, due to the nature of simulating only a limited number of degradation mechanisms at the same time, with quite limited influence on other structural components of the cell, unlike the real-time field testing. However, by monitoring and understanding each of the underlying degradation phenomena and modifying the cell design and operating conditions, the remaining useful lifetime of the cell can be significantly prolonged, even under highly transient operating conditions. The analysis and evaluation of the mechanical, chemical and thermal factors contributing to ageing and/or early
 failure of the balance-of-plant components, particularly the air compressor and the humidifier, identified the most critical ageing factors for the conditions of the intended use, i.e., inside the range extender trailer, and identified those that will need to be characterised in laboratory experiments.
Musical time and recording technology: A perspective from music theory.
Creators: name: Sztein Baremberg, Gabriella Ana.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Music.

description: This thesis deals with two categories of musical time, concrete and subjective, and the effect of recording technology on musical time. Concrete musical time can be measured in an objective way, for example, through reference to standards of time external to the listener, such as clocks. Subjective musical time refers to the musical time that cannot be measured objectively: it depends entirely on the listener who experiences the musical work. It is my conclusion that recording technology affects the concrete aspect of musical time, but not the subjective one. Chapter one defines the relationship between time and different forms of art, as well as the relationship between time and music. Chapter two defines concrete and subjective musical time. Chapter three discusses recording technology and the changes it imposes on the musical aesthetic ritual. By musical aesthetic ritual, I mean the agreed-upon physical actions which are related to the activities involving music and the experience of music. Chapter four explains the influence of recording technology on certain musical aesthetic ideas such as the reproduction of music, the completeness of the musical work, and the temporality of the musical work. Chapter five presents my conclusions with regards to the influence of recording technology on concrete and subjective musical time.
Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance
Creators: name: Krepsova, Eva
name: Tycova, Irena
name: Sekerkova, Alena
name: Wohlfahrt, Peter
name: Hruba, Petra
name: Striz, Ilja
name: Sawitzki, Birgit
name: Viklicky, Ondrej
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Basiliximab
subject: FOXP3
subject: Kidney transplantation
subject: rATG
subject: Rejection
subject: Tolerance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. Methods The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1, FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor- based triple immunosuppression and induction with rabbit anti-thymocyte globulin (rATG, n = 24), basiliximab (n = 17), or without induction (no- induction, n = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis. Results rATG treatment caused an intense reduction in all T cell type population and natural killer (NK) cells within 7 days, then a slow increase and repopulation was observed. This was also noticed in the expression levels of CD247, FOXP3, GZMB, and PRF1. The basiliximab group exhibited higher CD247, GZMB, FOXP3 and TCAIM mRNA levels and regulatory T cell (Treg) counts than the no-induction group. The levels of MAN1A1 and TLR5 mRNA expressions were increased, whereas TCAIM decreased in the rATG group as compared with those in the no-induction group. Conclusion The rATG induction therapy was associated with decreased T and NK cell-related transcript levels and with upregulation of two rejection- associated transcripts (MAN1A1 and TLR5) shortly after KTx. Basiliximab treatment was associated with increased absolute number of Treg cells, and increased level of FOXP3 and TCAIM expression.
Petrology and geochemistry of Timiskaming Group sedimentary rocks, Kirkland Lake area, Abitibi greenstone belt.
Creators: name: Legault, Marc Ian.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Geology.

description: The Timiskaming Group is a late Archaean syn-tectonic lithological unit which lies unconformably on greenstone-belt volcanic rocks and consists of an alluvial-fluvial assemblage intercalated with alkalic volcanic rocks and a turbidite assemblage. The fine-grained sedimentary rocks of the alluvial-fluvial assemblage and turbidite north unit have similar mineralogical and chemical compositions such as high SiO$\sb2$, U, Th and total rare-earth elements (REE). The turbidite south unit has high Fe$\sb2$O$\sb{3(\rm tot)}$, MgO, TiO$\sb2$, Cr and Ni. Petrographic and geochemical examinations of clasts from the alluvial-fluvial assemblage indicate that the clasts are mostly igneous rocks with minor sedimentary rocks. Four major types of igneous clasts are recognized: calc-alkaline porphyries, trachytes, trondhjemites and tholeiitic basalts. Results indicate that the turbidite south unit is the oldest unit of the Timiskaming Group and the age of sedimentation is bracketed between 2685 Ma and 2700 Ma. It was derived from an undissected arc terrane uplifted during accretion. Sources for the turbidite south unit estimated from chemical compositions of shales are 12% rhyolite, 18% komatiite and 70% andesite. The alluvial-fluvial assemblage and turbidite north unit are inferred to have been derived from a dissected island arc after accretion, but before the unroofing of K-rich intrusions, which are presently extensively exposed. A source comprising 60% calc-alkaline porphyries, 20% trachytes and 20% tholeiitic basalts is estimated for the turbidite north unit from the chemical composition of shales. The distribution of trachyte clasts in the alluvial-fluvial assemblage only close to the Lander Lake-Cadillac Fault (LLCF) suggests that displacement along the fault may have created conduits for alkaline magmas. Similar lithology of conglomerates north and south of the fault suggests that the alluvial-fluvial assemblage was deposited in a pull-apart basin after juxtaposition of two tectonic blocks along the fault between 2685 and 2677 Ma. (Abstract shortened by UMI.)
Enhancing and integrating tools for the analysis of genomic variants in rare disease studies
Creators: name: Hunt, Sarah
name: Lane, Lydie
name: Gateau, Alain
name: Lemos, Diana
name: Baudot, Anaïs
name: Ehrhart, Friederike
name: Evelo, Chris
name: Peter A.C 'T Hoen
Publisher: name: F1000 Research Limited
Year: 2020

description: Rare diseases, though cumulatively common, can be complex to diagnose individually. It is becoming standard practice to sequence and analyse exomes or genomes to diagnose affected individuals, and gain insight into possible pathophysiological mechanisms. An improved understanding of the impact of genetic variation is required to accelerate this process.

Mapping variants to genes and predicting their effects at the protein level is a key first step in interpretation. Knowledge of previously discovered links between phenotypes and both variants and the genes they lie within is essential. Simple extraction of information showing the pathways genes are involved in can provide insight into potential disease mechanisms. Mature tools are available to enable this, including: the Ensembl Variant Effect Predictor, which annotates variants with predicted gene consequence, pathogenicity scores and population frequencies; neXtProt, a reference database on human proteins which provides detailed information about the functional impact of mutations for a set of clinically relevant proteins; Orphanet which curates gene-rare disease associations; the Leiden Open Variation Database (LOVD) and ClinVar which capture variant phenotype associations; and WikiPathways, the community-curated database for biological pathways.

As part of the European Joint Project on Rare Disease, we seek to improve interoperability and to facilitate federated queries across existing resources. We will also enhance the functionality of our tools through discussions within the community to elicit requirements. This work will contribute to the construction of the ELIXIR service bundles for Rare diseases.
Unveiling research landscapes using open research information
Creators: name: Grimau, Berta
name: Veiga, Sonia
Publisher: name: Zenodo
Year: 2025

description: Recent studies have shown that OpenAlex, one of the main open databases of scientific publications, has greater coverage than proprietary alternatives both in terms of volume and in terms of diversity. However, it also suffers from some limitations, for example, when it comes to affiliation disambiguation.

Our talk will present some of the ways in which we can improve/enrich OpenAlex data through AI. First, we will introduce Affilgood (Duran-Silva et al, 2024), a tool to improve affiliation disambiguation and to enrich its geographical metadata.

Second, we will present a semi-automatic methodology to build on-demand classification models based on open data, by leveraging on generative LLMs as well as an open-source tool for collaborative dataset curation. Finally, we will demonstrate how entirely new classifications can be developed and openly shared, an approach that is not possible with closed or proprietary data infrastructures.Furthermore, we will present concrete examples of how collaborative and open innovation approaches are enabling analytical and monitoring capabilities that were previously out of reach. These breakthroughs are driven by access to large-scale open datasets: for example, biomedical analyses using OpenAlex data, which provide extensive coverage across the large biomedical domain.
N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury
Creators: name: Witzel, Christian
name: Reutter, Werner
name: Stark, G. Björn
name: Koulaxouzidis, Georgios
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: N-propionylmannosamine
subject: sialic acid
subject: glycoengineering
subject: sciatic nerve
subject: peripheral nerve
subject: branching
subject: arborisation
subject: Thy1-YFP mouse
subject: nerve regeneration
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-acyl side chain. N-Propionylmannosamine (ManNProp) increases neurite outgrowth and accelerates the reestablishment of functional synapses in vitro. We investigated the influence of systemic ManNProp application using a specific in vivo mouse model. Using mice expressing axonal fluorescent proteins, we quantified the extension of regenerating axons, the number of regenerating axons, the number of arborising axons and the number of branches per axon 5 days after injury. Sciatic nerves from non-expressing mice were grafted into those expressing yellow fluorescent protein. We began a twice-daily intraperitoneal application of either peracetylated ManNProp (200 mg/kg) or saline solution 5 days before injury, and continued it until nerve harvest (5 days after transection). ManNProp significantly increased the mean distance of axonal regeneration (2.49 mm vs. 1.53 mm; P < 0.005) and the number of arborizing axons (21% vs. 16%; P = 0.008) 5 days after sciatic nerve grafting. ManNProp did not affect the number of regenerating axons or the number of branches per arborizing axon. The biochemical glycoengineering of the N-acyl side chain of sialic acid might be a promising approach for improving peripheral nerve regeneration.
The first German map of geo-referenced ixodid tick locations
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: Arealkunde

description: Background
Georeferenced locations of ixodid ticks are required to depict the observed distribution of species. Further, they are used as input data for species distribution models also known as niche models. The latter were applied to describe current and future (projected) tick distributions. Beside model assumptions and selected climate parameters, the number of georeferenced tick locations available as a digital dataset is of fundamental importance for the reliability of such models. For Germany, however, no comprehensive dataset of ixodid tick species exists. The goal of this study was to put together all the available information on ixodid tick locations in Germany to produce such a digital dataset and to visualize it in a map. Findings
A total of 2,044 georeferenced locations of ixodid ticks in Germany were compiled from two existing datasets (altogether 993 locations) and an extensive literature study (1,051 locations). The resulting digital dataset comprises the following tick species: Ixodes ricinus (1,855 locations), Ixodes apronophorus (1), Ixodes frontalis (1), Ixodes hexagonus (1), Ixodes trianguliceps (4), Dermacentor marginatus (77), Dermacentor reticulatus (96), Haemaphysalis concinna (8) and Hyalomma marginatum (1). The data were used to draw a tick map for Germany, showing I. ricinus occurring in the whole federal territory, while D. marginatus has been restricted to the climatically favoured region of the Rhine valley. Clustered locations of D. reticulatus were also documented in the Rhine valley as well as in Berlin and its vicinity. Conclusions
The introduced map depicts for the first time the available geographical coordinates of ixodid tick locations in Germany. The digital dataset used to draw the map is provided to the scientific community as a basis for further investigations such as species distribution modelling.Quelle: http://www.parasitesandvectors.com/
Constance Beresford-Howe's interrogation of integrative feminism.
Creators: name: Gale, Heather.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Literature, Modern.

description: This thesis analyzes Constance Beresford-Howe's novels in terms of their place in the contemporary feminist debate over women's traditional roles as mothers, daughters, sisters, and wives. Her treatment of these roles supports Andrea O'Reilly's assertion that Beresford-Howe espouses what Angela Miles has called "integrative feminism", "a feminism which affirms and celebrates women's specificity and asks not for the eradication of women's traditional roles and values but for the recognition of their importance" (O'Reilly 69). Chapter One deals with a range of feminist literary criticism and particularly with the notion of "integrative feminism" and its applicability to the novels of Beresford-Howe, as well as entertaining complementary and divergent readings of this theory offered by such critics as Germaine Greer and Judith Stacey. Chapter Two considers the portrayal of sisters, daughters, and other female "helpers" in such novels as Of this Day's Journey (1947), The Invisible Gate (1949), My Lady Greensleeves (1955), A Population of One (1977), and Prospero's Daughter (1988). Chapter Three examines the portrayal of the institutionalized roles of mother and wife in such novels as The Unreasoning Heart (1946), My Lady Greensleeves 1955), The Book of Eve (1973), and Night Studies (1985). Chapter four extends the discussion of mothers and wives, with an emphasis on the protagonist's successful redefinition of those roles in The Marriage Bed (1981) and A Serious Widow (1991).
Designing Digital Video to Support Learner Outcomes: A Study in an Online Learning Resource for Healthcare Professionals and Students
Creators: name: Kellam, Hugh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Education, Health.
subject: Education, Technology of.

description: Instructors are incorporating video into their blended and web-based courses at an ever increasing rate. Thus the need for research in this area is required to understand how to design, utilize, and incorporate video most effectively as a pedagogical tool. This study explored how the design and implementation of digital video resources in an online educational environment affected learning outcomes. Forty-five health professionals and students evaluated the digital videos incorporated into ePhysicianHealth.com. Three types of digital video genre were examined in this study: modeling/demonstrations, personal stories/commentaries, and content expert narratives. The findings suggested that the majority of the participants found that the digital videos to be a valuable addition to ePhysicianHealth.com, as they made the learning environment more authentic, memorable, realistic, varied, and accommodating to different learning styles. Key Words: eLearning; online learning; video; healthcare education; physician wellness; disruptive behaviour; emerging technologies
Experimental evolution of ecological niches in heterogeneous environments
Creators: name: Jasmin, Jean-Nicolas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Ecology.
subject: Paleontology.

description: Organisms live in heterogeneous environments but fail to demonstrate optimal adaptation toil the totality of the ecological conditions they experience. This imperfection would result from trade-offs between ecologically relevant traits, which implies that trade-offs are the ultimate cause of major features of life such as biodiversity. Here, I selected bacterial populations in defined laboratory environments to test for the importance of differences in productivity and quality among alternative resources (Chapter 1), as well as the spatial pattern of resources (Chapter 2), in shaping the evolution of ecological niches and genetic diversity. The experiment presented in Chapter 1 provides support for a general model for the evolution of diversity. In Chapter 2 however, I suggest that mutational processes can impinge on the expression of trade-offs, which is not recognized in our current view of the problem of diversity. These findings provide plausible explanations for situations where expected trade-offs are not found.
"Die gegenwärtige Krise kann ungeahnte Kräfte freisetzen"
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2022

description: Klimaziele? Verfehlt. Die Abkehr von russischem Gas könnte das ändern, sagt Bundesumweltamtpräsident Dirk Messner. Und Energiesparen. Ein Klimageld könne Kosten abfedern. Quelle: http://www.zeit.de/
Building verbs in language mixing varieties
Creators: name: Alexiadou, Artemis
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: language-mixing
subject: light verb construction
subject: affixal pattern
subject: distributed morphology
subject: 410 Linguistik

description: This paper discusses two patterns of language mixing involving verbal predicates produced by bilingual speakers, the so-called light verb construction and the so-called affixal pattern. The empirical focus of the study is on Greek-German and Cypriot Greek-English varieties, which are contrasted to the Spanish-German variety discussed in González-Vilbazo and López (2011). An analysis of the constructions is offered using the tools of Distributed Morphology and Minimalist Syntax. The paper shows that bilingual speakers have very detailed knowledge of fine properties of their two linguistic systems that become apparent in the context of building verbs.
Gamma type distribution: Maximum likelihood values of the T-year event and their asymptotic variance.
Creators: name: Pilon, Paul J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Civil.

description: Maximum likelihood and censored sample theory are applied for flood frequency analysis purposes to the Two Parameter Gamma, log Two Parameter Gamma, Pearson Type III, log Pearson Type III (LP3), and Generalized Gamma distributions. The logarithmic likelihood functions are given in terms of the fully specified floods, the historical information, and the parameters to be estimated. Solution of the appropriate transcendental equations yields maximum likelihood estimators of the parameters. T-year floods are expressed as a function of these parameters and the standard normal variate. The asymptotic standard error of estimate of the T-year flood is derived using the general equation for the variance of estimate of a function. The variances and covariances of the parameters are obtained through inversion of Fisher's information matrix. The method is illustrated by application of the LP3 distribution to two sites having historical information. Monte Carlo studies were conducted for the LP3 distribution to analytically verify the accuracy of the derived asymptotic expression for the 10-, 50-, 100-, and 500-year floods. Results indicated that the asymptotic expressions were accurate for both Type I and Type II censored samples, while the bias was less than 2.5%. Subsequently, the Type II censored data were subjected to a random, multiplicative error. Results indicated that historical information contributes greatly to the accuracy of the estimate of the 100-year flood even when the error of its measurement becomes excessive. It is demonstrated that historical information can significantly reduce the standard error of estimate of flood quantiles.
Defective interfering particles of human parainfluenza virus 3 and establishment of persistent infections.
Creators: name: Murphy, Donald G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Health Sciences, Immunology.

description: Defective interfering particles of human parainfluenza virus 3 (HPIV3) were generated and/or amplified by serial undiluted passage of the standard virus. Analysis of the progeny virus titer at each cell passage revealed a cyclic pattern of virus production. Viruses produced from serial passages 8 and 9 interfered with replication of the standard virus. When cells were mixedly infected with standard virus and virus from either serial passages 5 or 8, three subgenomic RNA species, in addition to the standard virus genomic RNA, were detected in the progeny virions. Northern blot analysis revealed that all three subgenomic RNAs contained sequences from the 5$\sp\prime$-end of the standard virus genome. The data indicates that 5$\sp\prime$ defective interfering (DI) particles were generated and/or amplified during serial undiluted passage of HPIV3. Two independent HPIV3 persistent infections of LLC-MK$\sb2$ cells were established. One persistently infected culture was established by propagating the few cells which survived from an acute standard virus infection. The other persistently infected culture was readily established with virus from serial undiluted passage 8. This suggests that the DI particles present in serial passage 8 virus protected the cells from standard virus destruction. The two persistently infected cultures were propagated for nearly three years and the virus released from both cell lines at all times examined was noncytocidal. Subgenomic RNAs (putative DI particle genomes) were detected in virions released from both persistently infected cultures at various cell passages. No apparent changes in the size of the viral proteins were observed throughout the persistent infections. The DI particle-size genomes and the noncytocidal mutant virus are both likely to be involved in the maintenance of the persistent state. The degree of genetic change undergone by the viral genome during long-term persistence was examined. Nucleotide sequence analysis of the M gene and flanking regions of virus recovered after 147 cell passages (29 months of persistence) revealed that the viral genome did not undergo extensive genetic change. In the M protein coding region, only one conservative amino acid change was observed indicating that M protein mutation is not likely to be involved in the maintenance of the persistent infections. In contrast, the genomic 3$\sp\prime$-termini of viruses recovered after 146 cell passages was found to be highly mutated. The mutations observed were either U to C or A to G changes. Such exclusive substitution of one type of nucleotide for another is unlikely to be due to intrinsic polymerase errors but to an extrinsic biased hypermutational activity. An RNA unwinding/modifying activity that could give rise to the biased hypermutations is discussed.
iSHCamp: A case study in hybrid approaches to Digital Humanities pedagogy
Creators: name: Garnett, Vicky
Publisher: name: Zenodo
Year: 2020
Subjects: DH Pedagogy
Spatial Humanities
Flipped Training Schools
Self-directed learning
iSHCamp
Digital Humanities

description: The International Spatial Humanities Sprint Camp (iSHCamp) ran from 24-26th October 2019. It took an approach that could best be described as a 'hybrid' between the Flipped Training School model (whereby there is some element of self-directed learning before a main collaborative event) and a Hackathon. This poster presentation discusses the practicalities of putting together a live training event such as this, and what lessons were learned in the process. It was intended and prepared as a poster demonstration, and following a necessary re-format due to the move of DHBenelux to an online event, was presented in a short talk during the conference. This package therefore contains both the poster and the presentation slides. The iSHCamp Event was funded through an Irish Research Council 'New Foundations' grant (2018 call).
title: Beyond the health care setting
title: Exploring the intersections of gender, culture and religion and their influence on utilization of family planning services in Northern Nigeria
titleType: Subtitle
Creators: name: Bashir, Nasir
Publisher: name: Lancaster University
Year: 2022

description: Everyday Nigeria loses about 145 women of childbearing age as a result of pregnancy related complications, making it the second largest contributor to maternal deaths globally. About 74% of these deaths could be partly averted if all women had access to services that allow them to avoid unintended pregnancies. Despite investments to improve utilization of family planning services, Nigeria’s contraceptive prevalence rate (CPR) remains low (17%), with significantly poorer coverage in North-West (6.2%). The study aimed to explore the beliefs and perceptions of lay men and women of reproductive age about family planning and how gender norms and expectations, cultural practices and religious beliefs exert influence on utilization of modern family planning services in northern Nigeria. An integrative review approach to systematic review of mixed-methods studies revealed knowledge gaps relating to the ways by which culturally assigned masculine gender roles and cultural promotion of large families in the context of extreme poverty influence women’s ability to utilize family planning services. There was also lack of a clearly-defined rational for prohibition of family planning on religious grounds. These knowledge gaps guided the design of this qualitative research. It draws on data collected through focus group discussions and in-depth interviews with 65 participants, comprising of current users and non-users of family planning services, traditional and religious leaders identified using stratified purposeful sampling. The findings suggest that culturally influenced, gendered construction and segregation of power allow men to exert control over women’s contraceptive use, though some women passively resist power imposition through covert contraceptive use to regulate their fertility. Other women decline contraception due to reliance on procreation as a means of self-empowerment where large number of children could improve marriage stability. The study also revealed cultural preference for large families, competition for children amongst co-wives, poor spousal communication that stifles women’s voices, men’s capitalization on public’s mistrust of modern contraceptives and the religiously legitimized performance of masculinity to enforce non-use of modern contraceptives despite conflicting beliefs on prohibition of permanent methods contribute to low uptake. Thus, improving CPR in northern Nigeria will require a change in policy and practice that focuses heavily on social and behaviour change communication strategies to foster long-term sustainable and normative shift in culturally and religiously influenced gender dynamics that promote practice of family planning without disempowering women.
title: Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
title: Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
titleType: AlternativeTitle
Creators: name: Drakvik, Elina
name: Altenburger, Rolf
name: Aoki, Yasunobu
name: Kolossa-Gehring, Marike
name: Reiber, Lena
Publisher: name: My University
Year: 2020
Subjects: Umweltchemikalien
Risikomanagement

description: The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages: - We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures.
 - Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors.
 - Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps.
 - A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient. © 2019 The Authors. Published by Elsevier Ltd.
Devocionario como culminación de la obra poética de Ana Rossetti.
Creators: name: García Peña, Antonio.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Literature, Romance.

description: This study focuses on Devocionario, Ana Rossetti's penultimate book of poetry to date, viewing it as the culmination of a process of development towards poetic maturity. At the beginning of our research on the topic, we were first struck by the scarcity of critical studies on her work, as well as the repeated attempts to apply increasingly restrictive labels to it: erotic poetry, feminist poetry, new Andalusian poetry... If we add to the foregoing the notable lack of studies on her work as a whole, the scant attention paid to aspects of form in Rossetti's poetry, and the undeniable quality of her poetic style which captivates the reader from the very start, our intention of offering an overview of her poetic development through an analysis of Devocionario, the book of poetry which summarizes and encompasses her earlier works, will be seen to be a natural choice. Devocionario is, then, the object of our analysis, and we pay special attention to the last section of the work, entitled "Divinas Palabras". Our aim is to show that Devocionario, and especially "Divinas Palabras", can be seen as the end result of a poetic quest. (Abstract shortened by UMI.)
3375496.pdf
Creators: name: Lyons, Ashley
name: Roger, Thomas
name: Westerberg, Niclas
name: VEZZOLI, STEFANO
name: Maitland, Calum
name: Leach, Jonathan
name: Padgett, Miles
name: Faccio, Daniele
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised supplementary document
Wars2 is a determinant of angiogenesis
Creators: name: Wang, Mao
name: Sips, Patrick
name: Khin, Ester
name: Rotival, Maxime
name: Sun, Ximing
name: Ahmed, Rizwan
name: Widjaja, Anissa Anindya
name: Schafer, Sebastian
name: Yusoff, Permeen
name: Choksi, Pervinder Kaur
name: Ko, Nicole Shi Jie
name: Singh, Manvendra K.
name: Epstein, David
name: Guan, Yuguang
name: Houstek, Josef
name: Mracek, Tomas
name: Nuskova, Hana
name: Mikell, Brittney
name: Tan, Jessie
name: Pesce, Francesco
name: Kolar, Frantisek
name: Bottolo, Leonardo
name: Mancini, Massimiliano
name: Hubner, Norbert
name: Pravenec, Michal
name: Petretto, Enrico
name: MacRae, Calum
name: Cook, Stuart A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Angiogenesis
subject: Cardiovascular genetics
subject: Medical research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Coronary flow (CF) measured ex vivo is largely determined by capillary density that reflects angiogenic vessel formation in the heart in vivo. Here we exploit this relationship and show that CF in the rat is influenced by a locus on rat chromosome 2 that is also associated with cardiac capillary density. Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F protein variant within the ATP-binding motif, is prioritized as the candidate at the locus by integrating genomic data sets. WARS2(L53F) has low enzyme activity and inhibition of WARS2 in endothelial cells reduces angiogenesis. In the zebrafish, inhibition of wars2 results in trunk vessel deficiencies, disordered endocardial-myocardial contact and impaired heart function. Inhibition of Wars2 in the rat causes cardiac angiogenesis defects and diminished cardiac capillary density. Our data demonstrate a pro-angiogenic function for Wars2 both within and outside the heart that may have translational relevance given the association of WARS2 with common human diseases.
Advanced Surface Micro- and Nano- Structures for Controlling the Fate of Mammalian Stem Cells
Creators: name: Babaie, Ali
Publisher: name: Swinburne
Year: 2024

description: Pluripotent stem cells are cells possessing pluripotency and self-renewal. It means that these cells can create different types of adult functioning cells from a small population of cells derived from patients. Therefore, they have extensive capacity for treatment of patients who undergo losing of functioning tissues. This research was focused on novel micro-/nano- topographies to improve the growth and quality of embryonic stem cells cultured for lab or clinical applications. The surfaces created in this study have shown to yield with higher growth rates and improved capacity to create different adult functioning cells.
3375496.pdf
Creators: name: Lyons, Ashley
name: Roger, Thomas
name: Westerberg, Niclas
name: VEZZOLI, STEFANO
name: Maitland, Calum
name: Leach, Jonathan
name: Padgett, Miles
name: Faccio, Daniele
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Revised supplementary document
title: TUNE ULR Technisch wissenschaftliche Unterstützung bei der Novellierung der EU-Umgebungslärmrichtlinie (AP3)
title: Lärmaktionsplanung: Ruhige Gebiete
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: EU-Umgebungslärmrichtlinie
subject: Lärmaktionsplanung
subject: Lärmvorsorge
subject: Lärm
subject: Transport

description: Der Vorsorgegedanke beim Schutz der ruhigen Gebiete ist ein wichtiger Aspekt der allgemeinen Aufenthaltsqualitäten, insbesondere in Städten. In den Gemeinden ist die Festsetzung von ruhigen Gebieten jedoch noch wenig verbreitet. Dies hat verschiedene Ursachen, insbesondere das Fehlen von allgemein gültigen Auswahlkriterien, aber auch offene Fragen zur Bindungswirkung und zu möglichen Rechtsfolgen einer Festsetzung. Um die Akzeptanz und Verbreitung von ruhigen Gebieten zu stärken, behandelt die vorliegende Untersuchung zwei wesentliche Aspekte des Themas: die bisherigen Vorgehensweisen bei der Auswahl von ruhigen Gebieten und die rechtlichen Rahmenbedingungen. Abschließend werden mögliche Schlussfolgerungen für zukünftige Aktivitäten formuliert.
Quelle:http://www.umweltbundesamt.de/
description: Der Vorsorgegedanke beim Schutz der ruhigen Gebiete ist ein wichtiger Aspekt der allgemeinen Aufenthaltsqualitäten, insbesondere in Städten. In den Gemeinden ist die Festsetzung von ruhigen Gebieten jedoch noch wenig verbreitet. Dies hat verschiedene Ursachen, insbesondere das Fehlen von allgemein gültigen Auswahlkriterien, aber auch offene Fragen zur Bindungswirkung und zu möglichen Rechtsfolgen einer Festsetzung. Um die Akzeptanz und Verbreitung von ruhigen Gebieten zu stärken, behandelt die vorliegende Untersuchung zwei wesentliche Aspekte des Themas: die bisherigen Vorgehensweisen bei der Auswahl von ruhigen Gebieten und die rechtlichen Rahmenbedingungen. Abschließend werden mögliche Schlussfolgerungen für zukünftige Aktivitäten formuliert.