cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effect of genetic print and phenotypic print of Salmonella enterica in a quantitative risk assessment for the consumption of food in the central region of Mexico
Creators: name: Godv¿nez Oviedo, A
Publisher: name: University Of Tasmania
Year: 2023

description: Quantitative Microbiological Risk Assessment (QMRA) is a tool used to determine the risk of a particular pathogen quantitatively. This research aimed to evaluate the genotypic print (GP) and phenotypic print (PP) intra-species variability of Salmonella food isolates (FI) and include them in a QMRA for the central region of Mexico population. Samples of chicken (354), mango (300), and tomato (272) were collected in Aguascalientes, Jalisco, and Quer‚àö¬©taro. The prevalence and concentration of Salmonella in chicken (24.9 %, -0.61 Log MPN/g) were higher than in mango (1.3%, -1.7 Log NMP/g) and tomato (1.1%, 1.7 Log NMP/g). A total of 284 FI and 38 human isolates (HI) were characterized according to GP (virulence genes) and PP (antimicrobial resistance, behavior at acid conditions, and biofilm formation). Seven virulotypes were found; virulotype-2 was the most abundant in FI (68.7%) and HI (60.5%). Regarding PP, 54.9% and 26.3% of FI and HI were multidrug-resistant (MDR). For growth at acidic conditions, high variability in the growth rate, 0.003 to 0.038 OD600nm/h and 0.016 to 0.066 OD600nm/h, and detection time, 13.2 to 26.3 h and 6.1 to 17.3 h, for pH4 and pH5 was observed. Also, in the biofilm formation (0.109-2.08 OD595nm) through the time. Multifactorial analysis of GP and PP characteristics and hierarchical analysis was used to group the isolates into seven clusters. Amongst these clusters, 39 FI and 18 HI were selected to evaluate their survival under gastric conditions; populations were reduced from 2.7 to 4.7 LogCFU. Six FI were selected to evaluate the effect of food matrices (chicken, mango, tomato, water) on survival during gastric simulation; the isolates vehiculized in chicken showed the highest survival probability, followed by tomato, water, and mango. The probability (Pinf) and severity of the infection of the six strains also were evaluated using a gastrointestinal model. These data were linked to their whole-genome sequencing using a principal component analysis; mobile genetic elements were associated with higher Pinf and epithelial integrity damage. A baseline QMRA model for Salmonella in chicken was created, and a refinement was performed, improving the hazard characterization with the GP and PP. The refined model estimated 66064 cases, showing that high-virulent/MDR Salmonella strains were responsible for most cases (66.6%), despite their low prevalence.
Practice-Oriented Techniques in Lattice-Based Cryptography
Creators: name: MUHAMMED FETHULLAH ESGIN
Publisher: name: Monash University
Year: 2020
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics
subject: 80402 Data Encryption
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: In today’s computerised world, billions of people rely heavily on security systems that protect a tremendous amount of sensitive information ranging from banking information to government secrets. The algorithms currently used in such systems rely on classical cryptographic assumptions that do not provide security against powerful quantum computers. In this thesis, new techniques in lattice-based cryptography, one of the most promising candidates for quantum-safe cryptography, are explored with a practice-oriented approach in mind. A particular focus is on privacy-preserving protocols and their higher level applications. To this end, the thesis starts from building foundational techniques and proceeds towards practical schemes, constructing a full-fledged quantum-safe blockchain protocol in the end.
title: Identification of arid soil inducible genes in Pseudomonas fluorescens strain Pf0-1
Creators: name: Pipitone, Katila
Publisher: name: University of Nevada, Las Vegas
Year: 2009

description: This thesis contains three major sections: introduction, literature  review and the project entitled: 'Identification of Arid Soil Inducible  Genes in Pseudomonas fluorescens Strain Pf0-1'. The introduction section describes a general background, the current and potential applications of P. fluorescens and the main goal of this dissertation. The literature review chapter  discusses two main areas. The first area offers insights about different  types of in vivo expression technology (IVET) as a tool in gene  identification. This section also describes the limitations of IVET, as  well as the benefits over other methods for gene identification. The  second part of the literature review is a compendium of previously  reported genetic factors involved in soil survival. Finally, the last  part of this thesis documents the identification of arid soil inducible  gene in   P. fluorescens strain Pf0-1.
This study, identification of arid soil inducible genes in Pseudomonas fluorescens , investigated adaptation mechanisms of Pseudomonas fluorescens strain Pf0-1 in arid soil. Auxotrophy-based in vivo expression  technology (IVET) was employed to identify 26 arid-soil inducible genes  in  P. fluorescens. Based on analysis of Clusters of Orthologous  Groups of proteins (COGs), ten genes are involved in metabolism; four  genes are engaged in information storage and processing; three are  signaling and regulation cellular processes genes; and nine are poorly  characterized or hypothetical. Four genes of different functional groups  (Pfl0l_2143: glutamine synthetase; Pfl01_2660: GTPase Subunit of  Restriction Endonuclease like; Pfl0l_5595: hypothetical protein; and  Pfl01_3972: putative diguanylate phosphodiesterase EAL domain) were  inactivated and tested for their influence in soil colonization. Only  two of the four strains carrying defective alleles showed slight but  significant decreases in soil colonization. The growth patterns of  mutant strains carrying defective alleles on Pfl01_2143 and Pfl01_5595  showed a decline in arid soil persistence, which were partially restored  in strain derivatives carrying a complementing plasmid. Overall, these  results indicate that adaptation of   P. fluorescens to soil  requires the expression of many genes, perhaps acting cooperatively. We  further surmise that nitrogen limitation and metabolism are important  factors in soil colonization in arid soils.
title: Magnetic sensors for biodetection
Creators: name: Deshpande, Pranjali Vineet Sneha
Publisher: name: University of Nevada, Las Vegas
Year: 2009

description: The objective of thesis is to design magnetic sensor for detection of nanoparticles. Recently integrating the standard laboratory techniques into integrated system on chip is growing attention. Recent development is to combine magnetic markers and magnetoresistive sensors together in magnetic chip. In this thesis two magnetoresistive sensors were studied and designed.
By applying magnetic fields, magnetic nanoparticles can be manipulated on-chip, which can be utilized to pull the molecules to specific binding sites or to test the binding strength and distinguish between specifically and non-specifically bound molecules
Magnetoresistive sensors are compatible with the semiconductor industry which provides electronic signal directly as the output. Giantmagnetoresistive senor are based on change in resistance due to the magnetization of electron where as Tunneling device uses the probability of an electron to cross the oxide barrier.
Novel Framework for Mobile Collaborative learning (MCL)to substantiate pedagogical activities
Creators: name: Razaque, Abdul
name: Elleithy, Khalid
name: Salama, Nyembo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Latest study shows that MCL is highly focusing paradigm for research particularity in distance and online education. MCL provides some features and functionalities for all participants to obtain the knowledge. Deployment of new emerging technologies and fast growing trends toward MCL boom attract people to develop learning management system, virtual learning environment and conference system with support of MCL. All these environments lack the most promising supportive framework. In addition some of major challenges in open, large scale, dynamic and heterogeneous environments are not still handled in developing MCL for education and other organizations. These issues includes such as knowledge sharing, faster delivery of contents, request for modified contents, complete access to enterprise data warehouse, delivery of large rich multimedia contents (video-on-demand), asynchronous collaboration, synchronous collaboration, support for multi model, provision for archive updating, user friendly interface, middleware support and virtual support. To overcome these issues; the paper introduces novel framework for MCL consisting of four layers with many promising functional components, which provide access to users for obtaining required contents from enterprise data warehouse (EDW). Novel framework provides information regarding the course materials, easy access to check the grades and use of labs. The applications running on this framework give substantial feedback for collaboration such as exchange for delivery of communication contents including platform for group discussion, short message service (SMS), emails, audio, video and video-on-demand to obtain on-line information to students and other persons who will be part of collaboration.
description: 8 pages, 5 figure IADIS International Conference on Internet Technologies & Society 2011
Mapping Species distribution in space and time using social network site geotagged photos
Creators: name: MOATAZ MAHMOUD
Publisher: name: Monash University
Year: 2020
Subjects: subject: 80104 Computer Vision
subject: FOS: Computer and information sciences
subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Applied Computer Science
subject: Ecology
subject: FOS: Biological sciences

description: Climate change is affecting the environment and threatening the insect pollinators we need for one third of human food production. To understand these changes, we need fine-scale monitoring of insects, flowering plants and habitats worldwide. We cannot fulfil this need with manual labour. However, data posted on social network sites might help meet our requirements. Here I show how to extract useful insights on pollinators and flowering plants from social network site photos. Since these photos were not posted for scientific research, there are many challenges involved. I show how to solve these challenges using recent Artificial Intelligence software.
Additional file 3 of Clinical reasoning pattern used in oral health problem solving – A case study in Indonesian undergraduate dental students
Creators: name: Chrismawaty, B. E.
name: Emilia, O.
name: Rahayu, G. R.
name: Ana, I. D.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 3.
title: Gaining perspective: incidents that damage the therapeutic alliance as described by male mental health clients
Creators: name: Richards, Michelle Ann
Publisher: name: Western Washington University
Year: 2012

description:
This study investigated what incidents male clients found to be most detrimental to the formation or strengthening of the alliance with their mental health care providers, using an abbreviated version of the qualitative critical incident technique (a written form focusing on hindering incidents). Participants were 86 adult (M = 36.87 years old) male outpatients. Most (90.7%) were receiving individual counseling or psychotherapy at the time of the study. A total of 76 critical incident statements were extracted. After redundant statements were eliminated, 56 statements remained. The statements were sorted into categories by three participants and two researchers, according to what each sorter understood as the commonalities between the incidents in relation to what male clients saw as hindering or weakening the alliance. The consensus structure, based on the individual sort structures, contains 12 categories: Not the Right Fit, Unexpected Actions/Personality of Counselor/Psychotherapist, Communication Problems, Unprofessional, Client Needs to Build Trust, No Choice, Unsure of Therapist/Therapy, Client Not Putting in Work, Counselor/Psychotherapist Didn't Work Hard Enough on Client's Issues, Acting on Assumptions About Client, Pushy Counselor/Psychotherapist, and Time Problems. These categories can serve researchers in developing measures to better represent the male client's perspective on the alliance and can aid practitioners in providing gender-sensitive care by helping them become alert to the ways in which strains in the alliance may manifest with male clients.
Dipodillus zakariai Cockrum, Vaughan, and Vaughan 1976
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Dipodillus
Dipodillus zakariai

description: Dipodillus zakariai Cockrum, Vaughan, and Vaughan, 1976. Mammalia, 40:320. TYPE LOCALITY: Tunisia, Kerkennah Isis., 500 m. east of Kellabine, about 42 km east of Sfax. DISTRIBUTION: Kerkennah Isl. (Tunisia). COMMENT: May be conspecific with simoni (DML).
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 3), pp. 392-476 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 409, DOI: 10.5281/zenodo.7353031
Dopsch, Alfons. Wirtschaftliche und soziale Grundlagen der europäischen Kulturentwicklung aus der Zeit von Cäsar bis auf Karl den Großen
Creators: name: Jacob-Friesen, Karl Hermann
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2017

description: Rezension zu: Dopsch, Alfons. Wirtschaftliche und soziale Grundlagen der europäischen Kulturentwicklung aus der Zeit von Cäsar bis auf Karl den Großen. 2. Auflage. 8°. 1. Teil 418 S. Wien 1923. 2. Teil 615 S. Wien 1924
description: Nachrichten aus Niedersachsens Urgeschichte, 1926: Neue Folge Nr. 3
Modelling Data with Stochastic Generative Processes
Creators: name: NHAN NGUYEN TRONG DAM
Publisher: name: Monash University
Year: 2020
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Learning and modelling complex data with generative models is a prominent research topic in modern artificial intelligence since generative models empower us to answer fundamental and important research questions into the generative processes of algorithmic intelligence. They also enable practical applications such as recognising patterns and anomaly, constructing high-level abstractions utilised in reasoning and decision making, and drawing deep insights from the data to facilitate data compression and augmentation. This dissertation aims to advance research in generative models by enriching their modelling capacity and enhancing their robustness to work more efficiently on a wider range of problems and data types.
title: Environmental stress in the correctional workplace
Creators: name: Brummel, Jeff
Publisher: name: Western Washington University
Year: 2012

description:
Experiencing stress in the work environment is common for most occupations, and some occupations experience more work-related stress than others. Environmental factors including lighting, temperature, air quality and noise, can affect workers' stress levels in subtle ways often overlooked during typical work related stress evaluations. The present study examines the relationship between these environmental factors and their effects on the stress levels of corrections officers. Survey respondents (N=45) evaluated two correctional facilities in the Pacific Northwest for environmental quality and the incidence of Sick Building Syndrome (SBS) symptoms such as headache, fatigue, nausea, lethargy and other health-related issues. Baseline environmental measurements and facility environmental standards were compared with survey results to evaluate officers' experience of stress from the workplace environment. Results indicate that environmental factors may affect officers' stress levels and their experience of SBS symptoms to a greater degree than is currently discussed in the literature. Future studies should attempt to further refine these relationships, as a better understanding of them will help correctional administrators decrease workplace stress, absenteeism and attrition.
Privacy-Preserving Social Search: Primitives and Realisation
Creators: name: SHANGQI LAI
Publisher: name: Monash University
Year: 2020
Subjects: subject: 80303 Computer System Security
subject: FOS: Computer and information sciences
subject: 80402 Data Encryption

description: To mitigate the data breach issue in online social networks, this thesis builds an encrypted search system. The system can process queries on the encrypted data, and it can be used to support real-world social network services. To further improve the security of the system, this thesis reviews the underlying cryptographic primitives used by the system and propose a new cryptographic primitive to address an attack with a moderate cost.
Effects of enhanced stratification on equatorward dynamo wave propagation
Creators: name: Käpylä, Petri J.
name: Mantere, Maarit. J.
name: Cole, Elizabeth
name: Warnecke, Jörn
name: Brandenburg, Axel
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present results from simulations of rotating magnetized turbulent convection in spherical wedge geometry representing parts of the latitudinal and longitudinal extents of a star. Here we consider a set of runs for which the density stratification is varied, keeping the Reynolds and Coriolis numbers at similar values. In the case of weak stratification, we find quasi-steady dynamo solutions for moderate rotation and oscillatory ones with poleward migration of activity belts for more rapid rotation. For stronger stratification, the growth rate tends to become smaller. Furthermore, a transition from quasi-steady to oscillatory dynamos is found as the Coriolis number is increased, but now there is an equatorward migrating branch near the equator. The breakpoint where this happens corresponds to a rotation rate that is about 3-7 times the solar value. The phase relation of the magnetic field is such that the toroidal field lags behind the radial field by about $π/2$, which can be explained by an oscillatory $α^2$ dynamo caused by the sign change of the $α$-effect about the equator. We test the domain size dependence of our results for a rapidly rotating run with equatorward migration by varying the longitudinal extent of our wedge. The energy of the axisymmetric mean magnetic field decreases as the domain size increases and we find that an $m=1$ mode is excited for a full $2π$ azimuthal extent, reminiscent of the field configurations deduced from observations of rapidly rotating late-type stars.
description: 17 pages, 19 figures, version published in ApJ, version with higher resolution figures http://www.helsinki.fi/~kapyla/publ.html
The Hanani-Tutte Theorem and Non-separating Planar Graphs
Creators: name: Dehkordi, Hooman Reisi
Publisher: name: Monash University
Year: 2020
Subjects: subject: 10104 Combinatorics and Discrete Mathematics (excl. Physical Combinatorics)
subject: FOS: Mathematics

description: Graphs are a useful data structure for representing networks of relationships among objects. Drawings of graphs help humans to comprehend graphs better. We study several types of drawings such as planar drawings, in which edges do not cross, and superthrackles, in which any two edges cross. We show how to reduce the number of crossings in certain drawings to obtain a planar drawing or a superthrackle drawing. Moreover, we introduce a class of planar graphs that cannot be disconnected by removal of a cycle, determine its fundamental properties and use it to prove results about crossings in drawings of graphs.
title: Design and fabrication of a small prototype airframe structure
Creators: name: Clark, Kimberly Lynn
Publisher: name: University of Nevada, Las Vegas
Year: 2009

description: This project called for a first-generation prototype aircraft with  hovering capabilities that was lightweight. The focus of this study was  to design a small low-cost prototype composite airframe that meets  specified requirements, analyze structures using finite element analysis  and mechanical testing, and construct a prototype using proven  composite manufacturing techniques. One fuselage, one wing, and several  engine nacelles were designed and fabricated. Several design and  fabrication methods and materials were analyzed, with focus given to the  nacelles, and recommendations were provided for the manufacture of the  first generation airframe based on time, weight, and cost.
iOOBN: An Object-Oriented Bayesian Network Modelling Framework with Inheritance
Creators: name: MD SAMIULLAH
Publisher: name: Monash University
Year: 2020
Subjects: subject: Probability
subject: 10404 Probability Theory
subject: FOS: Mathematics
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: This thesis presents an OOBN framework, iOOBN, that extends existing frameworks of OOBNs to include inheritance, abstract classes and interfaces. We demonstrate how iOOBN can be used to build decision-making applications for real-life problems with uncertainty and present a prototype implementation of the framework. Then we evaluate both the framework and implementation by re-engineering a real-life project and several existing OOBNs. In the thesis, we also present a new incremental compilation algorithm for OOBNs. This algorithm allows the efficient compilation of OOBNs without them being flattened. Finally, we describe an algorithm that automatically learns the class hierarchies of OOBNs. This algorithm can be used to maximise re-use and produce better constructions of class inheritance hierarchies.
Controversies about hydrogen bonds in water molecules on the influence of high magnetic fields: implications on structural and electronic parameters
Creators: name: Toledo, Evelyn J. L.
name: Ramalho, Teodorico C.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The application of a magnetic field in water has been the subject of discussion because of possible technological innovations and controversies. Herein, theoretical calculations were carried out and a high magnetic field was applied in different directions, senses and intensity in water dimers. Our findings point out that these three variables significantly impact the obtained trend and results considering the hydrogen bond strength. Keeping this in mind, a better description of the experimental arrangement should occur to inform the positioning of the field in relation to the system to avoid controversies, especially in fields smaller than 100 T.
Sequence Modeling with Recurrent Neural Network
Creators: name: HUNG QUAN TRAN
Publisher: name: Monash University
Year: 2020
Subjects: Applied Computer Science

description: Sequence modeling is a fundamental problem in Natural Language Processing (NLP) due to the sequential nature of language. With advances in Recurrent Neural Networks, this family of models has become the state-of-the-art for many sequence mapping tasks. In this thesis, we examine the effectiveness of this family of models for several classes of problems in NLP.
title: Circuit Rider
Creators: name: Idol, Kimberly Harris
Publisher: name: University of Nevada, Las Vegas
Year: 2009

description: "An historical novel set at the end of the American Civil War  focusing on the week between President Lincoln's assassination and John  Wilkes Booth's death. The backdrop of the story is comprised of the  historical events and political figures that shaped this period in time  in America. The plot is also configured around the fictional histories  of three young souls, the spirit of a murdered Chinese immigrant girl,  and a brother and sister who's home in the Appalachians was destroyed  during the war. All three are escaping the devastating consequences of  the war and seeking a new start in the Western states. They become  personally entangled in the plot to assassinate the president on the way  west.
The story focuses on the American  underclass, the distinctive experiences of the runaways, the  impoverished, immigrants, newly freed slaves and those in the criminal  class who were also active participants in shaping the recorded history  of the United States and as noteworthy as the heroes and villains  Americans know by heart. The novel posits that the small dramas have as  powerful an effect on the course of American history as do the renowned  conflagrations and disasters that become headline news."
Eligmodontia F. Cuvier 1837
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eligmodontia

description: Eligmodontia F. Cuvier, 1837. Ann. Sei. Nat. Paris, ser. 2, 7:169. REVIEWED BY: A. Langguth (AL); M. A. Mares (MAM); R. A. Ojeda (RAO); C. J. Terry (CJT); D. F. Williams (DFW). COMMENT: Revised by Hershkovitz, 1962, Fieldiana Zool., 46:1 -524. Karyology reviewed by Pearson and Patton, 1976, J. Mammal., 57:339-350. Subfamily Hesperomyinae; see comment under Cricetidae. ISIS NUMBER: 5301410008013000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 3), pp. 392-476 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 410, DOI: 10.5281/zenodo.7353031
description: {"references": ["Hershkovitz, P. 1962. Evolution of Neotropical cricetine rodents (Muridae) with special reference to the phyllotine group. Fieldiana: Zoology, 46: 1 - 524.", "Pearson, O. P., and J. L. Patton. 1976. Relationships among South American phyllotine rodents based on chromosome analysis. Journal of Mammalogy, 57: 339 - 350."]}
title: Examining the impact of drug court participation for moderate and high risk offenders
Creators: name: Kobus, Kara
Publisher: name: University of Nevada, Las Vegas
Year: 2009

description: The purpose of this study was to examine the impact of drug court  participation among moderate and high risk offenders. While studies have  found that intensive programs, such as drug courts, are more effective  when focusing their services on high risk offenders, few studies have  examined the relationship between offender risk and drug court  effectiveness. Using the Level of Service Inventory-Revised (LSI-R) as a  measure of offender risk, the study employed a quasi-experimental  design to compare outcomes of drug court participants (n=228) and a  matched sample of probationers (n=252). The analyses showed that drug  court participants had lower rates of recidivism than probationers, but  failed to find a difference in the impact of the drug court across  moderate and high risk offenders.
Equivalence of the train model of earthquake and boundary driven Edwards-Wilkinson interface
Creators: name: Biswas, Soumyajyoti
name: Ray, Purusattam
name: Chakrabarti, Bikas K.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A discretized version of the Burridge-Knopoff train model with (non-linear friction force replaced by) random pinning is studied in one and two dimensions. A scale free distribution of avalanches and the Omori law type behaviour for after-shocks are obtained. The avalanche dynamics of this model becomes precisely similar (identical exponent values) to the Edwards-Wilkinson (EW) model of interface propagation. It also allows the complimentary observation of depinning velocity growth (with exponent value identical with that for EW model) in this train model and Omori law behaviour of after-shock (depinning) avalanches in the EW model.
description: 8 pages, 16 figs
Novel inhibitors design through structural investigations and simulation studies for human PKMTs (SMYD2) involved in cancer
Creators: name: Yadav, Arvind Kumar
name: Singh, Tiratha Raj
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferases (PKMTs) from family SMYD. It can regulate gene transcription by catalysing the methylation of lysine residues of protein substrates that play a significant role in oncogenesis. Inhibition of SMYD2 could lead to the proposal of new drugs for cancers, where it is involved. In this study, structure-based virtual screening was carried out for the identification of potential SMYD2 inhibitors. A subset of natural compounds (n = 98,071) from the ZINC database was screened by using a consensus docking approach and identified 391 potent compounds then evaluated based on ADMET parameters. Nine compounds were selected that chase line of drug-likeness criteria and re-docking. Based on docking score and protein–ligand interaction analysis, three compounds (ZINC03844862, ZINC08490711 and ZINC08764231) were identified as potential inhibitors. Finally, these three compounds were employed for 100 ns molecular dynamics simulation analysis to examine the structural stability with SMYD2. Moreover, RMSD, RMSF, H-bond, SASA and PCA analysis indicated the stable binding of potential compounds with SMYD2 structure. Computational approaches incorporated in this study provide novel putative SMYD2 inhibitors. These inhibitors could be potential leads to develop cancer therapeutics after in vivo and in vitro studies.
Additional file 1 of Deep time extinction of largest insular ant predators and the first fossil Neoponera (Formicidae: Ponerinae) from Miocene age Dominican amber
Creators: name: Fiorentino, Gianpiero
name: Lattke, John
name: Troya, Adrian
name: Sosiak, Christine
name: Dong, Minsoo
name: Barden, Phillip
Publisher: name: figshare
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Ecology

description: Additional file 1: Figure S1.Neoponera vejestoria sp. nov. (Holotype BALDR0443): (A) Lateral view of mesosoma; (B) Dorsal view of posterior mesosoma and propodeum; (C) Lateral view of gaster; (D) Ventral vew of mesosoma; (E) Metatarsi 1-5; (F) Arolium and metatarsal claws; (G) Metapleural gland. Scale bars: (A) 2 mm, (B) 1 mm, (C) 2 mm, (D) 2 mm, (E) 0.25 mm, (F) 0.125 mm, (G) 0.25 mm. Figure S2. CT reconstruction of N. vejestoria sp. nov. to illustrate difficult to view characters. (A) Head in front view; (B) Profile view of mesosoma and gaster; Dorsal view of head, posterior mesosoma, and propodeum as a CT reconstruction (C) and as a photograph of the fossil (D). Figure S3. Artistic reconstruction of N. vejestoria sp. nov. Artist: Minsoo Dong. Figure S4. Representation plot for the principal component analysis morphospace of Neoponera ants. Sampling comprised 47 species represented by 12 linear morphological measurements. Principal component 1 (here Dim.1) is represented by all the measured traits while Principal component 2 (here Dim.2) is represented by scape length (SL), pronotal width (ProW), mesosoma width (MsW) and the petiolar dimension (PW, PH and PL).
Bronzezeitliche Grabfunde vom Kronsberg, Gemeinde Laatzen (Kr. Hannover)
Creators: name: Tackenberg, Kurt
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2017

description: -
description: Nachrichten aus Niedersachsens Urgeschichte, 1930: Neue Folge Nr. 4
Spectral Energy Distributions of Local Luminous And Ultraluminous Infrared Galaxies
Creators: name: U, Vivian
name: Sanders, David B.
name: Mazzarella, Joseph M.
name: Evans, Aaron S.
name: Howell, Justin H.
name: Surace, Jason A.
name: Armus, Lee
name: Iwasawa, Kazushi
name: Kim, Dong-Chan
name: Casey, Caitlin M.
name: Vavilkin, Tatjana
name: Dufault, Michele
name: Larson, Kirsten
name: Barnes, Joshua E.
name: Chan, Ben H. P.
name: Frayer, David T.
name: Haan, Sebastian
name: Inami, Hanae
name: Ishida, Cathy M.
name: Kartaltepe, Jeyhan S.
name: Melbourne, Jason L.
name: Petric, Andreea
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Luminous and ultraluminous infrared galaxies ((U)LIRGs) are the most extreme star forming galaxies in the universe. The local (U)LIRGs provide a unique opportunity to study their multi-wavelength properties in detail for comparison to their more numerous counterparts at high redshifts. We present common large aperture photometry at radio through X-ray wavelengths, and spectral energy distributions (SEDs) for a sample of 53 nearby LIRGs and 11 ULIRGs spanning log (LIR/Lsun) = 11.14-12.57 from the flux-limited Great Observatories All-sky LIRG Survey (GOALS). The SEDs for all objects are similar in that they show a broad, thermal stellar peak and a dominant FIR thermal dust peak, where nuLnu(60um) / nuLnu(V) increases from ~2-30 with increasing LIR. When normalized at IRAS-60um, the largest range in the luminosity ratio, R(lambda)=log[nuLnu(lambda)/nuLnu(60um)] observed over the full sample is seen in the Hard X-rays (HX=2-10 keV). A small range is found in the Radio (1.4GHz), where the mean ratio is largest. Total infrared luminosities, LIR(8-1000um), dust temperatures, and dust masses were computed from fitting thermal dust emission modified blackbodies to the mid-infrared (MIR) through submillimeter SEDs. The new results reflect an overall ~0.02 dex lower luminosity than the original IRAS values. Total stellar masses were computed by fitting stellar population synthesis models to the observed near-infrared (NIR) through ultraviolet (UV) SEDs. Mean stellar masses are found to be log(M/Msun) = 10.79+/-0.40. Star formation rates have been determined from the infrared (SFR_IR~45Msun/yr) and from the monochromatic UV luminosities (SFR_UV~1.3Msun/yr), respectively. Multiwavelength AGN indicators have be used to select putative AGN: about 60% of the ULIRGs would have been classified as an AGN by at least one of the selection criteria.
description: 39 pages, including 12 figures and 11 tables; accepted for publication in ApJS
Abel, O. und Kyrle, G.: Die Drachenhöhle bei Mixnitz
Creators: name: Jacob-Friesen, Karl Hermann
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2017

description: Rezension zu: Abel, O. und Kyrle, G.: Die Drachenhöhle bei Mixnitz. 8°. Textband XXIX und 953 Seiten mit 76 Textfiguren und zahlreichen Tabellen. Tafelband mit 200 Tafeln. Wien 1931. Verlag der Österreichischen Staatsdruckerei.
description: Nachrichten aus Niedersachsens Urgeschichte, 1931: Neue Folge Nr. 5
Symmetry-protected topological invariants of symmetry-protected topological phases of interacting bosons and fermions
Creators: name: Wen, Xiao-Gang
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, it was realized that quantum states of matter can be classified as long-range entangled (LRE) states (i.e. with non-trivial topological order) and short-range entangled (SRE) states (\ie with trivial topological order). We can use group cohomology class ${\cal H}^d(SG,R/Z)$ to systematically describe the SRE states with a symmetry $SG$ [referred as symmetry-protected trivial (SPT) or symmetry-protected topological (SPT) states] in $d$-dimensional space-time. In this paper, we study the physical properties of those SPT states, such as the fractionalization of the quantum numbers of the global symmetry on some designed point defects, and the appearance of fractionalized SPT states on some designed defect lines/membranes. Those physical properties are SPT invariants of the SPT states which allow us to experimentally or numerically detect those SPT states, i.e. to measure the elements in ${\cal H}^d(G, R/Z)$ that label different SPT states. For example, 2+1D bosonic SPT states with $Z_n$ symmetry are classified by a $Z_n$ integer $m \in {\cal H}^3(Z_n, R/Z)=Z_n$. We find that $n$ identical monodromy defects, in a $Z_n$ SPT state labeled by $m$, carry a total $Z_n$-charge $2m$ (which is not a multiple of $n$ in general).
description: 42 pages, 12 figures, 3 tables, RevTeX4-1
Neural Machine Translation for Bilingually Low-Resource Scenarios
Creators: name: POORYA ZAREMOODI
Publisher: name: Monash University
Year: 2020
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences
subject: 80107 Natural Language Processing

description: Artificial intelligence is revolutionising the language translation industry by efficiently bridging the barriers of language in different areas. This approach, called Machine Translation (MT), is a data-hungry technology. However, we do not have the luxury of having large amounts of labelled training data for many languages. This thesis aims to improve the quality of MT for low-resource languages by leveraging linguistic resources.
An in silico molecular dynamics simulation study on the inhibitors of SARS-CoV-2 proteases (3CLpro and PLpro) to combat COVID-19
Creators: name: Bera, Krishnendu
name: Reeda, V. S. Jeba
name: Babila, P. R.
name: Dinesh, Dhurvas Chandrasekaran
name: Hritz, Jozef
name: Karthick, T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The work attempts to recognise the possible inhibitors against Papain-like protease (PLpro) and 3-Chymotrypsin-like protease (3CLpro) of SARS-CoV-2 to combat infectious COVID-19 virus using in silico studies. These two proteases are predominantly involved in the virus replication cycle; hence they are considered as potential drug targets. The virtual dock screening was performed for 53 selected drugs. The drugs with higher binding energy and oriented in the vicinity of active binding sites were selected for finding thermal stability using molecular dynamics (MD) simulation. The docking result reflects that the drugs A17 (Dasabuvir) and A34 (Methisazone) bind with PLpro and the drugs A17 and A53 (Vaniprevir) bind with 3CLpro with higher binding affinities. The MD simulation and principal component analysis show that the drug A17 has stable dynamic behaviour with both proteins over the 300 ns time-scale. The binding free energy of complexes was predicted from the last 100 ns trajectories using MM/PBSA. The predicted binding free energy of PLPro-A17 (Dasabuvir) and PLpro-A34 complexes (Methisazone) were −16.1 kcal/mol and −12.3 kcal/mol, respectively and −41.3 kcal/mol and −11.9 kcal/mol for 3CLpro-A17 (Dasabuvir) and 3CLpro-A53 (Vaniprevir) complexes, respectively. However, further experimental validation is required to confirm their inhibitory activities against SARS-CoV-2 causing COVID-19.
Don‚ÄövÑv¥t you forget about me : overlooked factors in prospective memory research
Creators: name: Elliott, DJ
Publisher: name: University Of Tasmania
Year: 2023

description: Prospective Memory refers to the ability to perform an intended action in the future, such as buying milk on the way home from work. Contemporary prospective memory research typically requires participants to perform an ongoing task (such as lexical decision) with further instructions to perform an alternative (or additional) task when they encounter a PM cue, such as a stimulus presented in a specific colour. This thesis investigates important overlooked factors affecting performance in this paradigm with the use of the prospective memory decision control (PMDC) computational model. The first chapter provides an overview of the relevant prospective memory literature, as well as an overview of the PMDC model and the role it plays in understanding the cognitive processes involved in prospective memory performance. The second chapter examines how altering the response method used in this paradigm can improve PM performance. The third chapter examines the effect of ongoing task load in this paradigm. The fourth chapter, a follow-up to the previous chapter, examines the effect of ongoing task difficulty. The fifth chapter examines the effect of PM cue frequency in this paradigm. In the sixth chapter, I discuss the findings of the studies, the theoretical and practical implications of the thesis, the limitations of the studies, and directions for future research.
Quantum gas mixtures in different correlation regimes
Creators: name: Garcia-March, Miguel Angel
name: Busch, Thomas
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a many-body description for two-component ultracold bosonic gases when one of the species is in the weakly interacting regime and the other is either weakly or strongly interacting. In the one-dimensional limit the latter case system is a hybrid in which a Tonks-Girardeau gas is immersed in a Bose-Einstein condensate, which is an example of a new class of quantum system involving a tunable, superfluid environment. We describe the process of phase separation microscopically and semiclassically in both situations and show that the quantum correlations are maintained in the separated phase.
description: 4 pages, 3 figures
Engel, Carl: Bilder aus der Vorzeit an der mittleren Elbe. Ein Heimat- und Volksbuch für den Regierungsbezirk Magdeburg und seine Grenzlandschaften. Erster Band: Steinzeit und Bronzezeit
Creators: name: Jacob-Friesen, Karl Hermann
Publisher: name: Nachrichten aus Niedersachsens Urgeschichte
Year: 2017

description: Rezension zu: Engel, Carl: Bilder aus der Vorzeit an der mittleren Elbe. Ein Heimat- und Volksbuch für den Regierungsbezirk Magdeburg und seine Grenzlandschaften. Erster Band: Steinzeit und Bronzezeit. 8°. XIV und 334 Seiten mit 183 Abbildungen. Burg bei Magdeburg 1930. Verlag August Hopfer.
description: Nachrichten aus Niedersachsens Urgeschichte, 1931: Neue Folge Nr. 5
Microbiological risk assessment of meat and seafoods
Creators: name: Sumner, JL
Publisher: name: University Of Tasmania
Year: 2023

description: This thesis summarises elements of more than half a century of my work as an academic and as a consultant. It has been influenced by numerous events, responses and developments, to which I refer as footnotes. Of these, three developments have been pivotal: the Hazard Analysis Critical Control Point (HACCP) concept, Quality Assurance (QA) and Predictive Microbiology. These are key elements of the discipline of Risk Assessment, which is the subject of this thesis ‚ÄövÑv¨ my involvement with risk assessments for the seafood and meat industries. However, underpinning any credible risk estimate is knowledge of the food process, the supply chain and information about how pathogens behave through that chain. These are the ‚ÄövÑv¿hard yards‚ÄövÑvp of risk assessment, without which modelers must rely on assumptions which, as we saw with early estimates of Covid illness and death, may be orders of magnitude from reality.
Success of an International Learning Health Care System in Hematopoietic Cell Transplantation: The American Society of Blood and Marrow Transplantation Clinical Case Forum
Creators: name: Litzow, Mark R.
name: Burns, Linda J.
name: Vivek, Roy
name: Selby, George B.
name: Malone, Adriana K.
name: Khan, Shakila P.
name: Lee, Stephanie J.
name: Westmoreland, Michael
name: Mir, Muhammad
name: Klein, Andreas K.
name: Moravec, Carina G.
name: Costa, Luciano J.
name: Cochran, Melissa
name: Komanduri, Krishna V.
name: Devlin, Sean M.
name: Krishnan, Amrita
name: Barba, Pere
name: Wood, William A.
name: Tierney, D. Kathryn
name: Perales, Miguel-Angel
name: Juckett, Mark B.
name: Stricherz, Melisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The ASBMT Clinical Case Forum (CCF) was launched in 2014 as an online secure tool to enhance interaction and communication among hematopoietic cell transplantation (HCT) professionals worldwide through the discussion of challenging clinical care issues. After 14 months, we reviewed clinical and demographical data on cases posted in the CCF from 1/29/2014 to 3/18/2015. A total of 137 cases were posted during the study period. Ninety-two cases (67%) were allogeneic HCT, 29 (21%) autologous HCT and in 16 (12%) the type of transplant (auto vs. allo) was still under consideration. The diseases most frequently discussed included non-Hodgkin lymphoma (NHL; n = 30, 22%), acute myeloid leukemia (AML; n = 23, 17%) and multiple myeloma (MM; n = 20, 15%). When compared with the US transplant activity reported by the US Department of Health and Human Services, NHL and acute lymphoblastic leukemia cases were overrepresented in the CCF while myeloma was underrepresented (P < 0.001). A total of 259 topics were addressed in the CCF with a median of two topics/case (range 1-6). Particularly common topics included whether transplant was indicated (n = 57, 41%), conditioning regimen choice (n = 44, 32%), and post-HCT complications after day 100 (n = 43, 31%). The ASBMT CCF is a successful tool for collaborative discussion of complex cases in the HCT community worldwide and may allow identification of areas of controversy or unmet need from clinical, educational and research perspectives.
Römischer Grabstein einer Frau, gefunden in Asberg (Asciburgium)
Creators: name: Oxé, August
Publisher: name: Bonner Jahrbücher
Year: 2018

description: -
description: Bonner Jahrbücher, Bd. 116 (1907): Bonner Jahrbücher : Jahrbücher des Vereins von Altertumsfreunden im Rheinlande
Additional file 1 of Study protocol for ACTIVE study: safety and feasibility evaluation of external ventricular drainage with ACTIVE fluid exchange in intraventricular hemorrhage—a phase 2, multi-center, randomized controlled trial
Creators: name: Haldrup, Mette
name: Mohamad, Niwar
name: Rasmussen, Mads
name: Thorup, Line
name: Dyrskog, Stig
name: Simonsen, Claus Ziegler
name: Miscov, Rares
name: Bjarkam, Carsten Reidies
name: Grønhøj, Mads
name: Poulsen, Frantz Rom
name: Korshøj, Anders Rosendal
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Substitute consent for participation in a health science research project.