cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional ultrasound imaging for assessment of extracellular matrix scaffolds used for liver organoid formation
Creators: name: Gessner, Ryan C.
name: Cashion, Avery T.
name: Dayton, Paul A.
name: Reid, Lola M.
name: Corcimaru, Ana
name: Feingold, Steven
name: Mullins, Christopher R.
name: Hanson, Ariel D.
name: Aylward, Stephen R.
name: Wu, Bryant T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A method of 3D functional ultrasound imaging has been developed to enable non-destructive assessment of extracellular matrix scaffolds that have been prepared by decellularization protocols and are intended for recellularization to create organoids. A major challenge in organ decellularization is retaining patent micro-vascular structures crucial for nutrient access and functionality of organoids. The imaging method described here provides statistical distributions of flow rates throughout the tissue volumes, 3D vessel network architecture visualization, characterization of microvessel volumes and sizes, and delineation of matrix from vascular circuits. The imaging protocol was tested on matrix scaffolds that are tissue-specific, but not species-specific, matrix extracts, prepared by a process that preserved >98% of the collagens, collagen-associated matrix components, and matrix-bound growth factors and cytokines. Image-derived data are discussed with respect to assessment of scaffolds followed by proof-of-concept studies in organoid establishment using Hep3B, human hepatoblast-like cells. Histology showed that the cells attached to scaffolds with patent vasculature within minutes, achieved engraftment at near 100%, expressed liver-specific functions within 24h, and yielded evidence of proliferation and increasing differentiation of cells throughout the two weeks of culture studies. This imaging method should prove valuable in analyses of such matrix scaffolds.
[PDF/Kindle] SI ES TÓXICO NO ES AMOR descargar gratis
Creators: name: Odom
Publisher: name: Zenodo
Year: 2024

description: SI ES TÓXICO NO ES AMOR de EVA GUTIERREZ CAMPO

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Ficha técnica

SI ES TÓXICO NO ES AMOR

EVA GUTIERREZ CAMPO

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788466676601

Editorial: EDICIONES B

Año de edición: 2023

 

 

 

 

 

Libros descargables gratis para teléfono. SI ES TÓXICO NO ES AMOR 9788466676601 (Literatura española) de EVA GUTIERREZ CAMPO

 

Overview

¿Cómo una persona "normal", con una vida y un entorno "normales" puede acabar en una relación destructiva? ¿Por que es tan difícil salir de ellas, aunque sepas que es lo correcto? ¿Por que me ha hecho ghosting? Y lo más importante, ¿cómo se sale de las relaciones tóxicas y del sufrimiento? Hay relaciones que comienzan como un sueño, pero acaban convirtiendose en una pesadilla. Hay relaciones que te destruyen y te hacen sentir tan insignificante que un día ya no te reconoces en el espejo. Hay relaciones construidas a base de mentiras, celos, reproches y control en las que se normalizan comportamientos de violencia sibilina, como si vivir en paz no fuera una opción. Hay relaciones que solo te harán feliz cuando hayas salido de ellas. ¿Cómo una persona "normal", con una vida y un entorno "normales" puede acabar en una relación destructiva? ¿Por que es tan difícil salir de ellas, aunque sepas que es lo correcto? ¿Por que me ha hecho ghosting? Y lo más importante, ¿cómo se sale de las relaciones tóxicas y del sufrimiento? Eva Gutierrez -psicóloga especializada en relaciones de pareja- da respuesta a estas y muchas otras preguntas basándose en su propia experiencia y en ejemplos de consulta, y explica todas las herramientas para detectar a tiem
A cryogenic tracking detector for antihydrogen detection in the AEgIS experiment
Creators: name: Amsler, C.
name: Antonello, M.
name: Belov, A.
name: Bonomi, G.
name: Brusa, R. S.
name: Caccia, M.
name: Camper, A.
name: Caravita, R.
name: Castelli, F.
name: Comparat, D.
name: Consolati, G.
name: Demetrio, A.
name: Di Noto, L.
name: Doser, M.
name: Ekman, P. A.
name: Fani, M.
name: Ferragut, R.
name: Gerber, S.
name: Giammarchi, M.
name: Gligorova, A.
name: Guatieri, F.
name: Hackstock, P.
name: Haider, D.
name: Haider, S.
name: Hinterberger, A.
name: Kellerbauer, A.
name: Khalidova, O.
name: Krasnicky, D.
name: Lagomarsino, V.
name: Malbrunot, C.
name: Mariazzi, S.
name: Matveev, V.
name: Muller, S. R.
name: Nebbia, G.
name: Nedelec, P.
name: Nowak, L.
name: Oberthaler, M.
name: Oswald, E.
name: Pagano, D.
name: Penasa, L.
name: Petracek, V.
name: Prelz, F.
name: Prevedelli, M.
name: Rienaecker, B.
name: Robert, J.
name: Rohne, O. M.
name: Rotondi, A.
name: Sandaker, H.
name: Santoro, R.
name: Storey, J.
name: Testera, G.
name: Tietje, I. C.
name: Toso, V.
name: Wolz, T.
name: Wuethrich, J.
name: Yzombard, P.
name: Zimmer, C.
name: Zurlo, N.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We present the commissioning of the Fast Annihilation Cryogenic Tracker detector (FACT), installed around the antihydrogen production trap inside the 1 T superconducting magnet of the AEgIS experiment. FACT is designed to detect pions originating from the annihilation of antiprotons. Its 794 scintillating fibers operate at 4 K and are read out by silicon photomultipliers (MPPCs) at near room temperature. FACT provides the antiproton/antihydrogen annihilation position information with a few ns timing resolution. We present the hardware and software developments which led to the successful operation of the detector for antihydrogen detection and the results of an antiproton-loss based efficiency assessment. The main background to the antihydrogen signal is that of the positrons impinging onto the positronium conversion target and creating a large amount of gamma rays which produce a sizeable signal in the MPPCs shortly before the antihydrogen signal is expected. We detail the characterization of this background signal and its impact on the antihydrogen detection efficiency.
title: A high-order discontinuous Galerkin solver and exact solutions for helically invariant flows
Creators: name: Dierkes, Dominik
Publisher: name: UNSPECIFIED
Year: 2020

description: In this thesis helical flows are investigated, in which the fluid particles simultaneously perform a rotational as well as a translational motion and, thus, move along a helix. The special feature of such flows is that they are based on a dimensional reduction, i.e. the number of coordinates, used to describe the flow is reduced. Such a reduction is referred to as dimensional reduction, since each coordinate represents one spatial dimension. The present work is divided into an analytical and a numerical part. In the analytical part, a new time-dependent coordinate system is derived from the symmetries of the incompressible Navier-Stokes equations. New conservation laws for viscous and non-viscous helical flows could be found for this coordinate system, which are shown in this thesis and have been published in the article Dierkes and Oberlack (2017). Furthermore, we consider the classical, temporally constant helical coordinate system and derive two classes of new exact solutions of the helical symmetric, full time-dependent Navier-Stokes equations. The first class of solutions is based on the symmetries of the Navier-Stokes equations and hence are denoted as invariant solutions. The second class of solutions is based on a linearization of the Navier-Stokes equations using the so-called Beltrami condition, whereby the velocity and vorticity vectors are assumed to be parallel to each other. In the numerical part of the work, a solver for the simulation of helically symmetrical flows is developed using the discontinuous Galerkin (DG) method, in which the solution is approximated by high-order polynomials. Due to the fact that helical flows in most cases are periodically in the direction of the central axis of the helix, a periodicity condition for the helical coordinates is derived. A condition for the velocity and the pressure is formulated analogously to the procedure known from the literature for axisymmetric flows (cf. Khorrami et al., 1989). This ensures the uniqueness of these physical quantities at the central axis of the helix. In addition, we introduce a suitable function space and formulate the spatial and temporal discretization of the helically symmetric Navier-Stokes equations. For the temporal discretization, we use a third order semi-explicit method in which the spatial operator is split into an explicit and an implicit part. Using this, the computational effort for transient simulations has been reduced significantly. The correct implementation is verified by various test cases including the exact solutions which have been found before. It is further shown that the convergence rates that we expect from theory are achieved. Finally, the results of direct numerical simulations at high Reynolds numbers are performed which reveal the formation of vortices, Kelvin-Helmholtz instabilities and the temporal development of energy spectra for helically invariant flows.
Features of the relationship between human capital development and digital technologies in the context of society 5.0 formation
Creators: name: Stryzhak, Olena
name: Stryzhak, Olena
Publisher: name: Unknown
Year: 2022
Subjects: subject: Labor and Human Capital
subject: Industry 4.0
subject: Industry 5.0
subject: Society 5.0
subject: human capital
subject: digital technologies
subject: digitalization
subject: Human Capital Index
subject: Networked Readiness Index

description: Purpose. The purpose of the article is to determine the features of the relationship between the level of digital technologies and human capital development in the countries around the world under the conditions of the emergence of Society 5.0. Methodology / approach. The research is based on general scientific research methods, such as analysis, synthesis, induction, deduction, comparison, systematization and generalization. Bibliographic analysis, standardization, correlation analysis (calculation of Pearson, Spearman, Kendall correlation coefficients), cluster analysis and data visualization techniques were also used in the research process. Results. The literature review shows that a key postulate of the Society 5.0 concept is human-centeredness combined with a high level of digital technology development. In this context, the features of the relationship between the level of human capital development and the degree of a country digitization have been identified in the study. The results of the analysis show that there is a direct rather strong relationship between HCI and NRI, and HCI and NRI sub-indices for the sample of 131 countries for 2020. These findings are supported by the results of analyses based on the calculation of Pearson, Spearman, Kendall correlation coefficients. Further analysis showed that this dependence is not homogeneous for the whole sample. As a result of the cluster analysis, four clusters were identified and correlation coefficients were calculated for each cluster. Scatterplot and Box & Whisker plot diagrams for clusters were also plotted. It turned out that the relationship between the analyzed indicators varies by groups of countries. Originality / scientific novelty. The results of the analysis show that the level of human capital development is closely linked to the level of society digitalization. However, this relationship is not homogeneous. This confirms the need to implement the Society 5.0 approach to the human development problems. Practical value / implications. The article proposes an approach to assess the relationship between the degree of digitalisation of society and the quality of the human factor in the economy. The obtained results can be used to justify the directions and tools for the implementation of state policy to support human capital development, taking into account the factors and characteristics of Society 5.0.
(3393) Alex J Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Detecting Disease Outbreaks Using Local Spatiotemporal Methods
Creators: name: Kosorok, Michael R.
name: Zeng, Donglin
name: Zhao, Yingqi
name: Richardson, David
name: Waller, Anna
name: Herring, Amy H.
name: Ising, Amy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A real-time surveillance method is developed with emphasis on rapid and accurate detection of emerging outbreaks. We develop a model with relatively weak assumptions regarding the latent processes generating the observed data, ensuring a robust prediction of the spatiotemporal incidence surface. Estimation occurs via a local linear fitting combined with day-of-week effects, where spatial smoothing is handled by a novel distance metric that adjusts for population density. Detection of emerging outbreaks is carried out via residual analysis. Both daily residuals and AR model-based de-trended residuals are used for detecting abnormalities in the data given that either a large daily residual or an increasing temporal trend in the residuals signals a potential outbreak, with the threshold for statistical significance determined using a resampling approach.
Morphological instability during steady electrodeposition at overlimiting currents
Creators: name: Nielsen, Christoffer P.
name: Bruus, Henrik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We present a linear stability analysis of a planar metal electrode during steady electrodeposition. We extend the previous work of Sundstrom and Bark by accounting for the extended space-charge density, which develops at the cathode once the applied voltage exceeds a few thermal voltages. In accordance with Chazalviel's conjecture, the extended space-charge region is found to greatly affect the morphological stability of the electrode. To supplement the numerical solution of the stability problem, we have derived analytical expressions valid in limit of low and high voltage, respectively.
description: 10 pages, 6 eps figures, Revtex 4-1
Asymptotic Zero Behavior of Laguerre Polynomials with Negative Parameter
Creators: name: McLaughlin, K. T-R
name: Kuijlaars, A. B. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: We consider Laguerre polynomials L(αn) n (nz) with varying negative parameters αn, such that the limit A = −limn αn/n exists and belongs to (0, 1). For A > 1, it is known that the zeros accumulate along an open contour in the complex plane. For every A ∈ (0, 1), we describe a one-parameter family of possible limit sets of the zeros. Under the condition that the limit r = −limn 1 n log [dist (αn,Z)] exists, we show that the zeros accumulate on Γr ∪[ β1, β 2] with  β1 and  β2 only depending on A. For r ∈ [0,∞), Γr is a closed loop encircling the origin, which for r = +∞, reduces to the origin. This shows a great sensitivity of the zeros to αn’s proximity to the integers. We use a Riemann-Hilbert formulation for the Laguerre polynomials, together with the steepest descent method of Deift and Zhou to obtain asymptotics for the polynomials, from which the zero behavior follows.
(3394) Joseph Gledhill
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A study of the structure–activity relationship of GABAA–benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis
Creators: name: Holger Försterling, F.
name: Roth, Bryan L.
name: Furtmuller, Roman
name: Rowlett, James K.
name: Li, Xiaoyan
name: Deschamps, Jeffrey R.
name: Sankar, Subramaniam
name: Sieghart, Werner
name: Weed, Michael R.
name: Parrish, Damon
name: Cook, James M.
name: Majumder, Samarpan
name: Clayton, Terry
name: Han, Dongmei
name: Rallapalli, Sundari
name: Teng, Yun
name: Cao, Hui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The stable conformations of GABAA-benzodiazepine receptor bivalent ligands were determined by low temperature NMR spectroscopy and confirmed by single crystal X-ray analysis. The stable conformations in solution correlated well with those in the solid state. The linear conformation was important for these dimers to access the binding site and exhibit potent in vitro affinity and was illustrated for α5 subtype selective ligands. Bivalent ligands with an oxygen-containing linker folded back upon themselves both in solution and the solid state. Dimers which are folded do not bind to Bz receptors.
CFD visualizations from Inference of facultative mobility in the enigmatic Ediacaran organism Parvancorina.
Creators: name: Darroch, Simon A. F.
name: Rahman, Imran A.
name: Brandt Gibson
name: Racicot, Rachel A.
name: Laflamme, Marc
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Results of CFD simulations visualized as two-dimensional plots
Descargar [PDF] {EPUB} EL MAESTRO Y MARGARITA
Creators: name: Greene
Publisher: name: Zenodo
Year: 2024

description: EL MAESTRO Y MARGARITA de MIJAIL BULGAKOV

Descargar eBook gratis ➡ Link

Ficha técnica

EL MAESTRO Y MARGARITA

MIJAIL BULGAKOV

Número de páginas: 560

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788419311054

Editorial: NAVONA

Año de edición: 2022

 

 

 

 

 

Libros digitales gratis descargables EL MAESTRO Y MARGARITA 9788419311054

 

Overview

No existe ninguna obra comparable a El maestro y Margarita.Una tarde de primavera, el Diablo sale de las sombras hacia Moscú arrastrando el fuego y el caos con él. La sátira fantástica, divertida y devastadora de la vida soviética que nos brinda Bulgákov se combina en dos partes distintas pero entrelazadas: una ambientada en el Moscú de los años treinta del siglo XX y otra en la antigua Judea del siglo I, cada una llena de personajes históricos, imaginarios, espantosos y maravillosos. Escrita durante los días más oscuros del reinado de Stalin y finalmente publicada en 1967, El maestro y Margarita se convirtió en un fenómeno literario que trasciende lenguas y fronteras. La nueva traducción de Marta Rebón parte de la edición canónica de Marietta Chudakova, a la que agrega nuevas aportaciones fruto de sus dos últimos años de investigación.
Benthic cover maps associated with paper "Landsat historical records reveal large-scale dynamics and enduring recovery of seagrasses in an impacted seascape", in Science of the Total Environment
Creators: name: Fernandes, Milena
name: Hennessy, Andrew
name: Law, Wallace
name: Daly, Robert
name: Gaylard, Samuel
name: Lewis, Megan
name: Clarke, Kenneth
Publisher: name: The University of Adelaide
Year: 2022
Subjects: Environmental assessment and monitoring
Natural resource management

description: This dataset includes benthic exposure annual maps as well as decadal benthic cover trajectory and persistence maps derived from summer Landsat imagery between 1988 and 2018 over 501 km2 off the coast of Adelaide, South Australia.
 Image processing included spectral subsetting, density slicing (Landsat 5 and Landsat 7) or Support Vector Machine (SVM) supervised classification (Landsat 8) and temporal majority filtering. Training and accuracy assessment of the classification were based on video transect data.
 The benthic exposure maps were classified into seagrass and sand. The trajectory maps identified an increase or decrease in seagrass cover for each pixel every 10 years, no change, or too variable to detect trends in time. The persistence maps showed the most frequent benthic cover for each pixel within each decade.
 The analysis of annual changes highlighted major temporal shifts in the system, while the analysis of decadal products allowed interpretation of long-term spatial dynamics.
 The associated paper published in Science of the Total Environment investigated the relationship between these temporal/spatial changes in benthic cover and land-based inputs, including breakpoints and timelags in system trajectory, and the identification of vulnerable seagrass meadows.
 Annual benthic exposure file names use the following convention: "YYYY_reprojected.tif", where YYYY = the year in which the summer covered by that map started (e.g., for mapping covering the summer of 1988-1989 the year is recorded as '1988') Data values for annual benthic exposure: * Reef = NoData * Seagrass = 1 * Sand = 0
 Benthic cover trajectory file names use the following convention: "traj_XX-YY_reprojected.tif" where XX = the year of the summer at the start of the epoch, and YY = the year of the summer at the end of the epoch. Data values for benthic cover trajectory: * No clear trend = -1 * Sand - no change = 0 * Seagrass - no change = 1 * Seagrass - loss = 2 * Seagrass - gain = 3 * Reef = NoData
 Benthic cover persistence file names use the following convention: "pers_XX-YY_reprojected.tif" where XX = the year of the summer at the start of the epoch, and YY = the year of the summer at the end of the epoch. Data values for benthic cover persistence: * Seagrass = 50 * Sand = 200 * Equal persistence (seagrass and sand) = 65,535 * Reef = NoData
Lagrangian circulation on the Southeast US Continental Shelf: Implications for larval dispersal and retention
Creators: name: Werner, F.E.
name: Blanton, B.O.
name: Hare, J.A.
name: Edwards, K.P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Lagrangian characterization of continental shelf circulation provides estimates of the retention and transport of particulate and dissolved substances. In this paper, we quantify the retentive characteristics of the Southeast U.S. Continental Shelf by comparing observed and numerical (modeled) drifters released throughout 2000 and 2001. Agreement between the observed and computed drifter trajectories shows that retention on this shelf can be up to two months at any point during the year. These results have important implications for ecological and fisheries applications and indicate that the populations of marine organisms in this region might be relatively closed (i.e., with weak exchange) during some periods of the year.
(3389) Charlotte Mary Eveleen Willans
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Reference-Based MRI
Creators: name: Weizman, Lior
name: Eldar, Yonina C.
name: Ben-Basaht, Dafna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Medical Physics (physics.med-ph)
subject: FOS: Physical sciences

description: Purpose: In many clinical MRI scenarios, existing imaging information can be used to significantly shorten acquisition time or to improve Signal to Noise Ratio (SNR). In this paper the authors present a framework for fast MRI by exploiting a reference image (FASTMER). Methods: The proposed approach utilizes the possible similarity of the reference image that exists in many clinical MRI imaging scenarios. Such scenarios include similarity between adjacent slices in high resolution MRI, similarity between various contrasts in the same scan and similarity between different scans of the same patient. The authors take into account that the reference image may exhibit low similarity with the acquired image and develop an iterative weighted approach for reconstruction, which tunes the weights according to the degree of similarity. Results: Experimental results demonstrate the performance of the method in three different clinical MRI scenarios: SNR improvement in high resolution brain MRI, exploiting similarity between T2-weighted and fluid-attenuated inversion recovery (FLAIR) for fast FLAIR scanning and utilizing similarity between baseline and follow-up scans for fast follow-up. Results outperform reconstruction results of existing state-of-the-art methods. Conclusions: The authors present a method for fast MRI by exploiting a reference image. The method is based on an iterative reconstruction approach that supports cases in which similarity to the reference scan is not guaranteed, which enables the applicability of the method to a variety of MRI applications. Thanks to the existence of reference images in various clinical imaging scenarios, the proposed framework can play a major part in improving reconstruction in many MR applications.
(3391) Elizabeth Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Read online: Victor Hugo habite chez moi  - A1
Creators: name: Henkle
Publisher: name: Zenodo
Year: 2024

description: Victor Hugo habite chez moi - A1 pan Myriam Louviot

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Victor Hugo habite chez moi - A1

Myriam Louviot

Nb. de pages: 48

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782278087969

Editeur: Didier (Editions)

Date de parution: 2017

 

 

 

Livres de téléchargement itouch gratuits Victor Hugo habite chez moi - A1

 

Overview

"J'habite une belle maison. Chez moi, je suis le roi. Je fais ce que je veux et tout est parfait... Hmm, non, tout n'est pas parfait. En fait, j'ai un problème : Victor Hugo habite chez moi... Croyez-moi, ce n'est pas facile tous les jours !". Victor Hugo, sa vie, sa famille, son exil... La vie de l'écrivain racontée avec humour par son chat.
Mass formulas for local Galois representations and quotient singularities II: dualities and resolution of singularities
Creators: name: Wood, Melanie Machett
name: Yasuda, Takehiko
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14E15, 14E16, 11S15, 11G25

description: A total mass is the weighted count of continuous homomorphisms from the absolute Galois group of a local field to a finite group. In the preceding paper, the authors observed that in a particular example, two total masses coming from two different weightings are dual to each other. We discuss the problem how general such a duality holds and relate it to the existence of simultaneous resolution of singularities, using the wild McKay correspondence and the Poincaré duality for stringy invariants. We also exhibit several examples.
description: 20 pages
[PDF] Bonjour tristesse by Françoise Sagan
Creators: name: Johnson
Publisher: name: Zenodo
Year: 2024

description: Bonjour tristesse pan Françoise Sagan

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Bonjour tristesse

Françoise Sagan

Nb. de pages: 143

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782011612397

Editeur: Hachette Education

Date de parution: 2015

 

 

 

Télécharger des ebooks gratuits en grec Bonjour tristesse par Françoise Sagan 9782011612397

 

Overview

Cécile a dix-sept ans. En vacances avec son père, veuf qui se satisfait d'une aventure sans lendemain avec la jolie Elsa, elle découvre l'amour dans les bras de Cyril, un charmant étudiant. Mais l'arrivée d'Anne, une femme belle et intelligente, vient déranger ces délicieux moments d'insouciance. Avec une écriture moderne et un charme troublant resté intact, Françoise Sagan brosse le portrait d'une jeunesse en quête de liberté et de plaisir, jouant avec les sentiments comme on joue avec le feu.
Biosafety of Recombinant Adeno-associated Virus Vectors
Creators: name: Tenenbaum, Liliane
name: Samulski, R.
name: Dismuke, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: It is hoped that the use of gene transfer technology to treat both monogenetic and acquired diseases may soon become a common therapy option in medicine. For gene therapy to achieve this objective, any gene delivery method will have to meet several criteria, including ease of manufacturing, efficient gene transfer to target tissue, long-term gene expression to alleviate the disease, and most importantly safety in patients. Viral vectors are an attractive choice for use in gene therapy protocols due to their relative efficiency in gene delivery. Since there is inherent risk in using viruses, investigators in the gene therapy community have devoted extensive efforts toward reengineering viral vectors for enhance safety. Here we review the approaches and technologies that are being evaluated for the use of recombinant vectors based upon adeno-associated virus (AAV) in the treatment of variety of human diseases. AAV is currently the only known human DNA virus that is non-pathogenic and AAV-based vectors are classified as Risk Group 1 agents for all laboratory and animal studies carried out in the US. Although its apparent safety in natural infection and animals appears well documented, we examine the accumulated knowledge on the biology and vectorology of AAV, lessons learned from gene therapy clinical trials, and how this information is impacting current vector design and manufacturing with an overall emphasis on biosafety.
Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives
Creators: name: Morieux, Pierre
name: Kohn, Harold
name: Stables, James P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Lacosamide has been submitted for regulatory approval in the United States and Europe for the treatment of epilepsy. Previous synthetic methods did not permit the elaboration of the structure–activity relationship (SAR) for the 3-oxy site in lacosamide. We report an expedient five-step stereospecific synthesis for N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide analogs beginning with d-serine methyl ester. The procedure incorporated alkyl (e.g. methyl, primary, secondary, and tertiary) and aryl groups at this position. The SAR for the 3-oxy site showed maximal activity in animal seizure models for small 3-alkoxy substituents.
RApid GeNeration And pReservation of infOrmation and Knowledge from big data (big data RAGNAROK)
Creators: name: Vasiljevic, Nikola
name: Cornwell, Peter John
Publisher: name: Zenodo
Year: 2019
Subjects: data annotation
stand-off data annotation

description: This project proposal describes solutions for efficient generation and preservation of information and knowledge from data enabling open research, citizen science, and open innovation, especially in the domain of Artificial Intelligence. The project intends to develop a comprehensive domain-agnostic platform for the long-term preservation of research data, related digital objects, and resulting information and knowledge corpora. The core of the platform is a stand-off data annotation system that will be used to systematically preserve information and knowledge arising from the interaction of humans and machines with data. The proposed platform will be built and demonstrated around a wind energy use case and generalized for other domains. The platform will be realized using open source technologies, such as CERN's Invenio (Open Source framework for large-scale digital repositories).
Global Regulatory Pathways and Cross-talk Control Pseudomonas aeruginosa Environmental Lifestyle and Virulence Phenotype
Creators: name: Wolfgang, Matthew C
name: Coggan, Kimberly A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Pseudomonas aeruginosa is a metabolically versatile environmental bacterium and an opportunistic human pathogen that relies on numerous signaling pathways to sense, respond, and adapt to fluctuating environmental cues. Although the environmental signals sensed by these pathways are poorly understood, they are largely responsible for determining whether P. aeruginosa adopts a planktonic or sessile lifestyle. These environmental lifestyle extremes parallel the acute and chronic infection phenotypes observed in human disease. In this review, we focus on four major pathways (cAMP/Vfr and c-di-GMP signaling, quorum sensing, and the Gac/Rsm pathway) responsible for sensing and integrating external stimuli into coherent regulatory control at the transcriptional, translational, and post-translational level. A common theme among these pathways is the inverse control of factors involved in promoting motility and acute infection and those associated with biofilm formation and chronic infection. In many instances these regulatory pathways influence one another, forming a complex network allowing P. aeruginosa to assimilate numerous external signals into an integrated regulatory circuit that controls a lifestyle continuum.
title: EPA approval of water quality standards proposed by Massachusetts
titleType: AlternativeTitle
title: Biological Opinion on EPA Approval of Water Quality Criteria Proposed for Adoption by Massachusetts and New Hampshire
Creators: name: United States. National Marine Fisheries Service. Office of Protected Resources
Publisher: name: United States. National Marine Fisheries Service. Office of Protected Resources
Year: 2022

description: OPR-2022-00203; OPR-2022-00204
Response to Comment on "Stellar activity masquerading as planets in the habitable zone of the M dwarf Gliese 581"
Creators: name: Robertson, Paul
name: Mahadevan, Suvrath
name: Endl, Michael
name: Roy, Arpita
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Anglada-Escudé and Tuomi question the statistical rigor of our analysis while ignoring the stellar activity aspects that we present. Although we agree that improvements in multiparametric radial velocity (RV) modeling are necessary for the detection of Earth-mass planets, the key physical points we raised were not challenged. We maintain that activity on Gliese 581 induces RV shifts that were interpreted as exoplanets.
description: Peer-reviewed comment originally published in Science
CFD visualizations from Inference of facultative mobility in the enigmatic Ediacaran organism Parvancorina
Creators: name: Darroch, Simon A. F.
name: Rahman, Imran A.
name: Brandt Gibson
name: Racicot, Rachel A.
name: Laflamme, Marc
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Results of CFD simulations visualized as two-dimensional plots
Synthesis and evaluation of ligands for D2-like receptors: The role of common pharmacophoric groups
Creators: name: Nkansah, Nancy T.
name: Altundas, Ramazan
name: Ablordeppey, Seth Y.
name: Zhu, Xue Y.
name: Setola, Vincent
name: Roth, Bryan L.
name: Sikazwe, Donald M.N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous reports indicates that arylalkyl substituents can improve the potency and selectivity of the binding affinity at D2-like receptors. In this paper, we explored the contributions of two key pharmacophoric groups, i.e., 4′-fluorobutyrophenones and 3-methyl-7-azaindole groups, to the potency and selectivity of synthesized agents at D2-like receptors. Preliminary observation of binding affinities indicates that there is little predictability of specific effects of the arylalkyl moieties but the composite structure is responsible for selectivity and potency at these receptors.
Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents
Creators: name: Zhu, Xue Y.
name: Setola, Vincent
name: Peprah, Kwakye
name: Eyunni, Suresh V.K.
name: Roth, Bryan L.
name: Ablordeppey, Seth Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Using haloperidol as a scaffold, new agents were designed to investigate the structural contributions of various groups to binding at CNS receptors associated with atypical antipsychotic pharmacology. It is clear that each pharmacophoric group, the butyrophenone, the piperidine and the 4-chlorophenyl moieties contributes to changes in binding to the receptors of interest. This strategy has resulted in the identification of several new agents, compounds 16, 18, 19, 23, 24 and 25, with binding profiles which satisfy our stated criteria for agents to act as potential atypical antipsychotics. This research demonstrates that haloperidol can serve as a useful lead in the identification and design of new agents that target multiple receptors associated with antipsychotic pharmacology.
COMSOL parameters from Inference of facultative mobility in the enigmatic Ediacaran organism Parvancorina.
Creators: name: Darroch, Simon A. F.
name: Rahman, Imran A.
name: Brandt Gibson
name: Racicot, Rachel A.
name: Laflamme, Marc
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Details of Parvancorina models in half-cylinder flume.
Polypyridyl Ru( ii )-derivatized polypropylacrylate polymer with a terminal water oxidation catalyst. Application of reversible addition–fragmentation chain transfer polymerization
Creators: name: Meyer, Thomas
name: Luo, Hanlin
name: Concepcion, Javier
name: Alibabaei, Leila
name: Ito, Akitaka
name: Ashford, Dennis
name: Fang, Zhen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A Ru(II) polypyridyl-derivatized polypropylacrylate end-capped with a water-oxidation-catalyst (WOC) has been synthesized by using reversible addition–fragmentation chain transfer polymerization (RAFT) followed by click reaction and end-group functionalization. In cyclic voltammograms in propylene carbonate, chromophore oxidation occurs at 1.27 V vs. NHE and the RuIII/II wave for the catalyst at 0.84 V vs. NHE. Upon excitation of the Ru(II) chromophore, excited-state energy migration occurs by site-to-site, –RuII*– → –RuII–, energy transfer hopping along the polymer chain, in part, reaching the terminal catalyst site where –RuII*– → –RuII–OH2 2+ energy transfer is favored by ΔGen = −2100 cm−1. Added MV2+ as an electron transfer acceptor oxidizes the –RuII*– excited state on the polymer to Ru(III), –RuII*– + MV2+ → –RuIII– + MV+ , and ultimately, the catalyst, by site-to-site electron transfer hopping and oxidation, -RuIII-← e-RuII - OH2 2+. Oxidation is followed by relatively slow, diffusional back electron transfer from MV•+ to Ru(III) sites on the polymer chain. The mixed chromophore-catalyst polymer is a water oxidation catalyst with potential for enhanced light harvesting and water oxidation.
Directed molecular screening for RecA ATPase inhibitors
Creators: name: Singleton, Scott F.
name: Wigle, Tim J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The roles of bacterial RecA in the evolution and transmission of antibiotic resistance genes make it an attractive target for inhibition by small molecules. We report two complementary fluorescence-based ATPase assays that were used to screen for inhibitors of RecA. We elected to employ the ADP-linked variation of the assay, with a Z′ factor of 0.83 in 96-well microplates, to assess whether 18 select compounds could inhibit ATP hydrolyis by RecA. The compounds represented five sets of related inhibitor scaffolds, each of which had the potential to cross-inhibit RecA. Although nucleotide analogs, known inhibitors of GHL ATPases, and known protein kinase inhibitors were not active against RecA, we found that three suramin-like agents substantially inhibited RecA's ATPase activity.
High pressure floating zone growth and structural properties of ferrimagnetic quantum paraelectric BaFe$_{12}$O$_{19}$
Creators: name: Cao, H. B.
name: Zhao, Z. Y.
name: Lee, M.
name: Choi, E. S.
name: McGuire, M. A.
name: Sales, B. C.
name: Zhou, H. D.
name: Yan, J. -Q.
name: Mandrus, D. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: High quality single crystals of BaFe$_{12}$O$_{19}$ were grown using the floating zone technique in flowing oxygen pressurized to 100 atm. Single crystal neutron diffraction was used to determine the nuclear and magnetic structure of BaFe$_{12}$O$_{19}$ at 4 K and 295 K. At both temperatures, there exist local electric dipoles formed by the off-mirror-plane displacements of magnetic Fe$^{3+}$ ions at the bipyramidal sites. The displacement at 4 K is about half of that at room temperature. The temperature dependence of the specific heat shows no anomaly associated with long range polar ordering in the temperature range from 1.90-300 K. The inverse dielectric permittivity, $1/\varepsilon$, along the c-axis shows a $T^2$ temperature dependence between 10 K and 20 K, with a significantly reduced temperature dependence displayed below 10 K. Moreover, as the sample is cooled below 1.4 K there is an anomalous sharp upturn in $1/\varepsilon$. These features resemble those of classic quantum paraelectrics such as SrTiO$_3$. The presence of the upturn in $1/\varepsilon$ indicates that BaFe$_{12}$O$_{19}$ is a critical quantum paraelectric system with Fe$^{3+}$ ions involved in both magnetic and electric dipole formation.
description: 9 pages, 9 figures, submitted to APL Materials
COMSOL parameters from Inference of facultative mobility in the enigmatic Ediacaran organism Parvancorina
Creators: name: Darroch, Simon A. F.
name: Rahman, Imran A.
name: Brandt Gibson
name: Racicot, Rachel A.
name: Laflamme, Marc
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Details of Parvancorina models in half-cylinder flume.
Integrative study of a new cold-seep mussel (Mollusca: Bivalvia) associated with chemosynthetic symbionts in the Marmara Sea
Creators: name: Ritt, Bénédicte
name: Lorion, Julien
name: Sarrazin, Jozée
name: Sara Lazar, Cassandre
name: Duperron, Sébastien
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Recently, small Idas-like mussels have been discovered living on carbonate crusts associated with cold-seeps in the Marmara Sea. These mussels, here referred to as Idas-like nov. sp., differ morphologically and genetically from another species identified as Idas aff. modiolaeformis, living in the same type of ecosystem in the Nile Deep-Sea Fan (eastern Mediterranean Sea). A phylogenetic analysis confirms the distinction between the two species, which belong to highly divergent lineages. Carbon stable isotope values, as well as the detection of thiotroph-related bacteria in the gill tissue, support the presence of a symbiotic, thiotroph-derived nutrition. In contrast, Idas aff. modiolaeformis displays six different types of symbionts. Finally our size-frequency data suggest that the recruitment is continuous in the examined area. The present study extends the documented distribution of symbiont-bearing mussels to the Marmara Sea, and contributes to the characterisation of biological communities in this recently explored area.
Negative differential conductance in molecular junctions: an overview of experiment and theory
Creators: name: Xu, Bingqian
name: Dubi, Yonatan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: One of the ultimate goals of molecular electronics is to create technologies that will complement - and eventually supersede - Si-based microelectronics technologies. To reach this goal, electronic properties that mimic at least some of the electrical behaviors of today's semiconductor components must be recognized and characterized. AN outstanding example for one such behavior is negative differential conductance (NDC), in which an increase in voltage across the device terminals results in a decrease in the electrical current passing through the device. This overview focuses on the NDC phenomena observed in metal-single molecule-metal junctions, and is roughly divided into two parts. In the first part, the central experiments which demonstrate NDC in single-molecule junctions are critically overviewed, with emphasis on the main observations and their possible physical origins. The second part is devoted to the theory of NDC in single-molecule junctions, where simple models are employed to shed light on possible mechanisms leading to NDC.
description: 26 pages, 18 figures, Invited review for J. Phys. Condensed Matter