cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Better Data Discoverability in Science Gateways
Creators: name: Supun Nakandala
name: Sudhakar Pamidighantam
name: Marru, Suresh
name: Pierce, Marlon
Publisher: name: figshare
Year: 2017
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: Science gateways primarily focused on remote job execution management generate domain specific output data mainly readable by application specific parsers and post processing utilities. For example, computational chemistry data outputs encode molecule information, convergence of the simulation and energy values. Such domain-specific information is non-trivial to search in a generic fashion. It is thus desirable to add a wide range of application-specific and user-specific post-processing features that may include remote executions of scripts and smaller applications that don’t require scheduling on clusters. It is also desirable to support integrations with searching, indexing, and general purpose data analysis and mining tools provided by the Apache “big data” software stack. As gateways become tenants to general purpose platform services, providing a general purpose infrastructure that enables these application specific post-processing steps is an interesting architectural challenge. Furthermore, it is desirable to share results from the post-processing and indexing. In this paper, we discuss how we have incorporated a new automated application output indexing system for the SEAGrid Science Gateway using Apache Airavata that will parse and index generated output for easy querying. We also examine data sharing and automated data publication so that another user can reuse the results without running an already executed experiment and hence reduce resource utilization.
Analysis of nanoHUB.org from a Business Perspective
Creators: name: Zentner, Lynn
name: Zentner, Michael
name: Klimeck, Gerhard
Publisher: name: figshare
Year: 2016
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: Science Gateways are typically implemented by scientists and cyberinfrastructure experts to serve a specific, externally-funded scientific focus. Sustainability of those gateways and the knowledge and tools they contain continues to be of strong interest to both the gateways and the funding agencies that support their creation and initial operation. nanoHUB.org is an established gateway entering its 15th year of operation and now serving over 1.4 million visitors annually. The leadership at nanoHUB have utilized a partnership with Purdue’s Krannert School of Management to collaborate on examining nanoHUB from a business perspective. The results of these collaborations are outlined in this extended abstract and will be expanded upon in the corresponding presentation.
Identifying areas to improve the quality of reporting in randomized clinical trials published in anesthesiology journals: A study protocol for a series of literature surveys assessing quality of trial registration, adherence to abstract reporting guidelines, adequacy of sample size calculations, and impact of funding source
Creators: name: Chow, Jeffrey
name: Jones, Philip
Publisher: name: figshare
Year: 2016
Subjects: subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 110301 Anaesthesiology
subject: FOS: Clinical medicine

description: Background: Randomized clinical trials (RCTs) provide important evidence for clinical decision-making, but low quality design or reporting of these trials may result in a biased or distorted evidence base. Of particular interest are quality of trial registration, adherence to the CONSORT for Abstracts guidelines, accuracy of sample size calculations, and impact of funding source. Methods: This research program will consist of a series of studies assessing these four areas of reporting quality for RCTs published in six general anesthesiology journals. The first study will include RCTs from 2007, 2010, 2013, and 2015; the second and third study will include RCTs from 2010 and 2016; and the fourth study will include RCTs from 2015 and 2016. Comparing both across time and between journals, the first study will determine whether the reported outcomes of published RCTs are the same as the outcomes originally registered in clinical trial registries, the second study will determine the degree of adherence to the CONSORT reporting guidelines for the abstracts of RCTs, the third study will determine whether the quality of sample size calculations has improved, and the fourth study will determine whether industry funding has an effect on the outcomes measured previously. For the first study, the trial registration status will be systematically determined, along with the types of outcome discrepancies observed between the publication and registry entry. For the second study, the number of CONSORT criteria met in the abstract and the number of criteria not met in the abstract but found in the full-text. The third study will only include two-arm, parallel group, superiority RCTs, measuring the number of sample size calculation assumptions reported, the accuracy of those assumptions compared to the actual results, and the post-hoc power. The fourth study will examine the effect of “any industry funding” and “only industry funding” on the outcomes described earlier. Discussion: This series of studies will highlight important issues of reporting quality in anesthesiology RCTs, providing a specialty-specific perspective and updating the literature using the most current RCTs.
Better Data Discoverability in Science Gateways
Creators: name: Supun Nakandala
name: Sudhakar Pamidighantam
name: Marru, Suresh
name: Pierce, Marlon
Publisher: name: figshare
Year: 2016
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: Science gateways primarily focused on remote job execution management generate domain specific output data mainly readable by application specific parsers and post processing utilities. For example, computational chemistry data outputs encode molecule information, convergence of the simulation and energy values. Such domain-specific information is non-trivial to search in a generic fashion. It is thus desirable to add a wide range of application-specific and user-specific post-processing features that may include remote executions of scripts and smaller applications that don’t require scheduling on clusters. It is also desirable to support integrations with searching, indexing, and general purpose data analysis and mining tools provided by the Apache “big data” software stack. As gateways become tenants to general purpose platform services, providing a general purpose infrastructure that enables these application specific post-processing steps is an interesting architectural challenge. Furthermore, it is desirable to share results from the post-processing and indexing. In this paper, we discuss how we have incorporated a new automated application output indexing system for the SEAGrid Science Gateway using Apache Airavata that will parse and index generated output for easy querying. We also examine data sharing and automated data publication so that another user can reuse the results without running an already executed experiment and hence reduce resource utilization.
Bringing the George H. & Alice F. Beatty Odonata Collection Into the Digital Age
Creators: name: Sandall, Emily
Publisher: name: figshare
Year: 2016
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences

description: A collection of over 60,000 odonate specimens can tell many stories. It can show the successful preservation of dragonflies and damselflies, as well as the differences in prey and habitat associations between taxa. The field notes can share observations and collecting details with those who may have never seen a particular species in the field. A collection of this size can also demonstrate the importance of natural history museums and their contents, enabling biodiversity research decades later. Of particular interest is the mobility of collections in the digital age, as evidenced through the U.S. NSF’s investment in Advancing Digitization of Biodiversity Collections (ADBC) grants, liberating natural history data on which novel research can be conducted. Over the past two years, I have worked with the collection of George H. and Alice F. Beatty at the Frost Entomological Museum at Penn State University in order to digitize the specimens in the collection, catalog them, and find ways to use their data through an NSF Thematic Collections Network (TCN) grant for digitization.
Silica iodide catalyzed, ultrasound-promoted, one-pot four-component synthesis of novel 1,4,5,6-tetrahydropyridine-3-carboxylate derivatives
Creators: name: Santhosh Govindaraju
name: Sumaiya Tabassum
name: Pasha, Mohamed Afzal
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Silica iodide catalyzed, competent synthesis of 15 novel substituted-1,4,5,6-tetrahydropyridine-3-carboxylate derivatives was achieved by a one-pot four-component cyclocondensation of Meldrum's acid, aryl aldehydes, aromatic amines and ethyl acetoacetate under ultrasonic irradiation. In comparison to the conventional methods, our protocol is convenient, eco-friendly and offers several benefits such as: mild conditions, high yields, shorter reaction time and ease in product isolation.
Synthesis, spectral characterization and bioactivity evaluation of novel α-aminophosphonates
Creators: name: Ch. Subramanyam
name: Sk. Thaslim Basha
name: G. Madhava
name: Sk. Nayab Rasool
name: Sk. Adam
name: S. Durga Srinivasa Murthy
name: C. Naga Raju
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: A facile synthesis of novel α-aminophosphonates 5a-j was accomplished by condensation of imines (3a-j) with diethyl phosphite (4) in ethanol at 50–60°C using easily recoverable and reusable catalyst, tetramethyl guanidine (TMG) via pudovik reaction in high yields. All the title compounds were characterized by spectral and elemental analysis. They were further screened for their abilities towards in vitro antibacterial, antifungal and antioxidant activities. The compounds 5g, 5d, 5f exhibited good antibacterial and antifungal activities compared to the standard bactericide, Penicillin and fungicide, Griseofulvin, respectively. The compounds 5h, 5i, 5g, and 5c exhibited good antioxidant activity compared to the standard ascorbic acid.
Characterization of SecA N-Terminus for Membrane Binding and Activity
Creators: name: Floyd, Jeanetta
Publisher: name: Georgia State University
Year: 2007

description: SecA is an essential component for the translocation of proteins across bacterial membranes.  Though SecA is known to function in the membrane the mechanism for this process remains unclear.  In this study we identify two specific regions of SecA that may be important for N-terminal membrane interactions.  Molecular modeling of SecA from the E. coli and B. subtilus crystal structures, previously determined, revealed that the first 30 amino acids of SecA consists of a helix of amino acids 1-11 connected by a linker (amino acids 12-16) to an amphipathic helix of amino acids 17-30.  The first helix is dispensable for SecA activity; however, deletions in the second N-terminal helix, at amino acids 21-25, result in decrease of SecA activity and a deletion of 26 amino acids no longer complements E. coli ts mutant BL21.19.  We show that the deletions of N-terminal amino acids that result in the decrease of SecA activity are correlated to the loss of SecA membrane binding and integration in these deletion mutants.  In this study we also test the accuracy of a new membrane protein prediction software PSSM_SVM.  This program predicted an embedded membrane (EM) region at SecA amino acids 110-118.  The predicted sequence represents an unusual prediction for an EM region as most membrane integral regions consist of 15-30 amino acids.  Molecular modeling indicated that the region 110-118 is a part of a helix composed of amino acids 107-121 in E. coli SecA, and is indicative of a membrane embedded domain.  Site-directed mutagenesis was carried out with several conserved residues, which included L110, L114, and L118 to determine if substitutions at these positions would affect SecA activity.  Our data shows that most SecA mutants (including some predicted to be inactive) are active in vivo; however, L110E and L114R mutations rendered the mutated SecA non-functional.  All together this study shows that the N-terminal limit of SecA resides at amino acid 26 and that amino acids 21-25 may form a N-terminal membrane binding determinate.  Moreover, the predicted EM region may indeed correspond to a functional embedded membrane region for SecA.
Who Believes in the Storybook Image of the Scientist?
Creators: name: Coosje L. S. Veldkamp
name: Hartgerink, Chris H. J.
name: Assen, Marcel A. L. M. Van
name: Wicherts, Jelte M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Do lay people and scientists themselves recognize that scientists are human and therefore prone to human fallibilities such as error, bias, and even dishonesty? In a series of three experimental studies and one correlational study (total N = 3,278) we found that the “storybook image of the scientist” is pervasive: American lay people and scientists from over 60 countries attributed considerably more objectivity, rationality, open-mindedness, intelligence, integrity, and communality to scientists than to other highly-educated people. Moreover, scientists perceived even larger differences than lay people did. Some groups of scientists also differentiated between different categories of scientists: established scientists attributed higher levels of the scientific traits to established scientists than to early-career scientists and Ph.D. students, and higher levels to Ph.D. students than to early-career scientists. Female scientists attributed considerably higher levels of the scientific traits to female scientists than to male scientists. A strong belief in the storybook image and the (human) tendency to attribute higher levels of desirable traits to people in one’s own group than to people in other groups may decrease scientists’ willingness to adopt recently proposed practices to reduce error, bias and dishonesty in science.
Partition musicale : le grand père
Creators: name: Lancelot, Francine
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/FileId-3413
description: created: ca 1970
On the Distribution of Worker Productivity: The Case of Teacher Effectiveness and Student Achievement
Creators: name: Goldhaber, Dan
name: Startz, Richard
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: It is common to assume that worker productivity is normally distributed, but this assumption is rarely, if ever, tested. We estimate the distribution of worker productivity, where individual productivity is measured with error, using the productivity of teachers as an example. We employ a nonparametric density estimator that explicitly accounts for measurement error using data from the Tennessee STAR experiment, and longitudinal data from North Carolina and Washington. Statistical tests show that the productivity distribution of teachers is not Gaussian, but the differences from the normal distribution tend to be small. Our findings confirm the existing empirical evidence that the differences in the effects of individual teachers on student achievement are large and the assumption that the differences in the upper and lower tails of the teacher performance distribution are far larger than in the middle of the distribution. Specifically, a 10 percentile point movement for teachers at the top (90th) or bottom (10th) deciles of the distribution is estimated to move student achievement by 8–17 student percentile ranks, as compared to a change of 2–7 student percentile ranks for a 10 percentile change in teacher productivity in the middle of the distribution.
Dressing Apache Airavata Services With Automatically User-Generated Interfaces
Creators: name: D'Agostino, Daniele
name: Roverelli, Luca
name: Zereik, Gabriele
name: Danovaro, Emanuele
name: Clematis, Andrea
name: Galizia, Antonella
Publisher: name: figshare
Year: 2017
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: The development of community-specific user interfaces of a science gateway can be a challenging task for non-IT experts. This contribution proposes an original, easy-to-use solution to tackle this issue based on the PortalTS Web portal. In particular, we present how PortalTS can “dress” Apache Airavata to manage job submissions.
The Role of Ribosomal Protein L7, An Estrogen Receptor Coactivator, on the Development of Zebra Finch (Taeniopygia Guttata) Song System
Creators: name: Duncan, Kelli
Publisher: name: Georgia State University
Year: 2008

description: The Australian zebra finch (Taeniopygia guttata) serves as an excellent model organism for studying the mechanisms that influence brain sexual differentiation. The brain and behavior of the zebra finch are sexually dimorphic. The regions of the brain that control the learning and production of song (song control nuclei) are significantly larger in the male brain than in the female brain and only males sing courtship songs, thus the majority of past research has focused on the development of these sex differences. In the majority of mammals, brain sexual differentiation occurs because hormones secreted from the gonads act to initiate male or female brain development. In zebra finches, estradiol is sufficient to masculinize the male brain, however manipulations of developmental hormone exposure fail to fully reverse the sex differences in song nuclei size. Furthermore, genetic females induced to develop functional testicular tissue do not develop a completely masculinized song system and castration has no effect on development of the song system in males. The source of the increased estrogenic signal in male zebra finch brain has yet to be identified, but data suggest that other neuronal factors play a role in development of the song control nuclei. Coregulators, such as coactivators and corepressors, are proteins and RNA activators that work by enhancing or depressing transcriptional activity of the nuclear steroid receptor with which they associate. Coregulators also modulate the development of sex-specific brain morphology and behavior in rodents and birds and may help to explain the difficulties observed in altering song nuclei development via castration and gonadal hormone replacement. As an estrogen receptor-? coactivator, ribosomal protein L7 (RPL7) is able to make the brain more sensitive to estradiol by enhancing the effects of steroid receptor action. Therefore, this dissertation addressed the following questions regarding RPL7: (1) is RPL7 expression sexually dimorphic in the song nuclei of the zebra finch brain?; (2) is RPL7 protein expression regulated by steroid hormones?; and (3) does decreasing RPL7 protein expression with antisense oligonucleotides alter neuronal survival in vivo and song nuclei size and neuron number in vitro? Collectively, these studies will provide valuable information about the role of steroid receptor coactivators in development of the zebra finch song system and on the role of coactivators on sexual differentiation of the brain.
Estudo temporal de monitorização (2010-2013) de pesticidas de acordo com a Diretiva Quadro da Água Europeia: a Ria Formosa (Portugal) como caso de estudo
Creators: name: Cruzeiro, Catarina
name: Rocha, Eduardo
name: Pardal, Miguel Ângelo
name: Rocha, Maria João
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: A contaminação de águas superficiais por pesticidas tem sido alvo de atenção crescente por parte das entidades europeias devido aos efeitos nocivos destes compostos, principalmente a nível do biota. Neste contexto, procedeu-se à monitorização sazonal de 56 pesticidas em águas superficiais da Ria Formosa (Portugal) de 2010 a 2013. Os pontos de amostragem incluíram as cidades de Faro, Olhão e Tavira, assim como o Parque Natural e várias áreas turísticas. No total, foram recolhidas 72 amostras de água, a partir das quais os pesticidas (fungicidas, herbicidas e inseticidas) foram extraídos por fase sólida (SPE) e analisados por cromatografia gasosa acoplada à espectrometria de massa (GC-MS). Foram quantificados mais de 80% dos pesticidas nas duas campanhas de amostragem, sendo as suas concentrações acumuladas (Σ≈ 11,0 μg/L e Σ≈ 1,8 μg/L, respetivamente) superiores às dos limites legais (Σ500 ng/L; 98/83/CE). Verificou-se que mais de 40% e de 29% dos pesticidas quantificados, em cada campanha, respetivamente, apresentaram concentrações superiores às estabelecidas nas diretivas europeias (98/83/CE e 2013/39/UE) e que as concentrações mais altas foram determinadas após as épocas de maior pluviosidade. Nove dos 56 pesticidas foram detetados em ambas as campanhas, mas apenas a alfa-cipermetrina e a deltametrina apresentaram concentrações (EC50 300 ng/L e EC50 560 ng/L, respetivamente) capazes de afetar invertebrados aquáticos (ex., Daphnia magna). Numa visão global, foi evidenciada uma diminuição notável nos níveis dos pesticidas em 2012-2013. Apesar disto, houve compostos — como os hexaclorobenzeno, cialofop-butil, clorfenvinfos Z, dimetoato, endosulfão sulfato, hexaclorociclopentadieno e lindano — com concentrações médias mais elevadas em 2012-2013, sendo na sua maioria, e de acordo com a base de dados Europeia de pesticidas, classificados como não aprovados para uso. Para além da importância que os resultados apresentam para a apreciação do estado de poluição do emblemático habitat estudado, o trabalho também é relevante para se inferir sobre o tipo de pesticidas que hoje se encontram no ambiente aquático em geral e as concentrações que podem atingir. Estas informações são essenciais para cientistas e órgãos governamentais, permitindo-lhes avaliar o uso de pesticidas para fins agrícolas, em particular quanto às violações da lei e os impactos.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 1 (2016)
Dressing Apache Airavata Services With Automatically User-Generated Interfaces
Creators: name: D'Agostino, Daniele
name: Roverelli, Luca
name: Zereik, Gabriele
name: Danovaro, Emanuele
name: Clematis, Andrea
name: Galizia, Antonella
Publisher: name: figshare
Year: 2016
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: The development of community-specific user interfaces of a science gateway can be a challenging task for non-IT experts. This contribution proposes an original, easy-to-use solution to tackle this issue based on the PortalTS Web portal. In particular, we present how PortalTS can “dress” Apache Airavata to manage job submissions.
Estudo taxonómico da Família Sternotpychidae (Actinopterygii, Stomiiformes) do Monte submarino Senghor, Cabo Verde
Creators: name: Cruz, Ana Carolina
name: Pitarma, Bárbara
name: Vieira, Rui Pedro
name: Cunha, Marina R.
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: Os montes submarinos têm sido considerados como locais de grande biodiversidade e acumulação de biomassa marinhas. O monte submarino Senghor encontra-se no extremo nordeste do arquipélago de Cabo Verde, a aproximadamente 60 milhas da Ilha do Sal. Com o objetivo de estudar a ictiofauna mesopelágica desta reunião, realizaram-se duas campanhas, a bordo do navio de investigação Poseidon - P423 e P466, efetuadas em dezembro de 2011 e fevereiro de 2013, respetivamente. A amostragem foi concebida com arrastos oblíquos entre os 0 e os 500 m, com recurso a uma rede de arrasto pelágica IKMT. Depois de triadas as amostras foi selecionada a família Sternoptychidae para um estudo taxonómico mais aprofundado. A Família de peixes mesopelágicos Sternoptychidae, pertencente à ordem dos Stomiformes, engloba espécies com grande diversidade morfológica, particularmente em relação à quilha pós-abdominal que deu aos membros desta família o seu nome mais comum: “Peixes-machadinha”. Estes seres realizam migrações verticais diárias, durante as quais ascendem (à noite ou entardecer) de profundidades entre 250 e 1000 m até aos 20-100 m. A Família Sternoptychidae engloba cerca de 70 espécies válidas atribuídas a 10 géneros. Dessas setenta espécies, vinte e três ocorrem no Oceano Atlântico, e nove foram identificadas neste trabalho. São apresentados detalhes morfológicos sobre os principais caracteres diagnósticos para a identificação das espécies encontradas na região do Monte submarino Senghor.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 1 (2016)
Electrophysiological Studies on Escherichia coli Protein-conducting Channel
Creators: name: Lin, Bor-Ruei
Publisher: name: Georgia State University
Year: 2008

description: We have developed a novel, sensitive and less time-consuming method to detect activity of the SecA-dependent protein-conducting channels. Nanogram levels of E. coli inverted membrane vesicles were injected into Xenopus oocytes, and ionic currents were recorded using the two-electrode voltage clamp. Currents were observed only in the presence of E. coli SecA in conjunction with E. coli membranes. The observed currents showed outward rectification in the presence of KCl as permeable ions and were significantly enhanced by coinjection with the precursor protein, proOmpA, or active LamB signal peptide. Channel activity was blockable with sodium azide or adenylyl 5?-(?, ?-methylene)-diphosphonate, a non-hydrolyzable ATP analog, both of which are known to inhibit SecA protein activity. Channel activity was also stimulated by oocyte endogenous precursor proteins, which could be inhibited by puromycin. In the presence of puromycin, exogenous proOmpA or LamB signal peptides, but not defective signal peptides, stimulated the ionic currents. 
We also measured SecA-dependent currents with membranes depleted of SecYEG. Wild-type LamB signal peptides, or precursor proteins stimulated ionic currents following a co-injection of SecYEG? membranes with puromycin. Excess exogenous SecA stimulated ionic currents through SecYEG? membranes. Similar activities of added SecA were observed with reconstituted membranes depleted of SecYEG. Currents through such SecYEG-depleted membranes were also stimulated by addition of defective LamB signal peptides and unfolded mature PhoA protein. In contrast, currents produced by the membranes containing wild-type SecYEG were not so stimulated, but ionic currents were stimulated through mutant strains, similar to PrlA (SecY) suppressors, e.g. PrlA4, or PrlA665 membranes, suggesting that the proofreading function of SecY was bypassed in these membranes. 
We have observed that azide can inhibit ionic currents when E. coli wild-type MC4100 membranes were injected with proOmpA or LamB signal peptides into Xenopus oocytes. However, such inhibition was lost when observed with oocyte-endogenous signal peptides in the absence of bacterial signal peptides. Moreover, azide did not show complete inhibition upon using SecYEG? membranes or SecYEG? reconstituted membranes plus excess SecA in the presence or absence of LamB signal peptides. Such conformational alterations reflect different sensitivity in response to azide during the opening of protein-conducting channels.
Efeitos do TBT em células vasculares: estado da arte e trabalho futuro
Creators: name: Barros, Ana R.
name: Feiteiro, Joana
name: Cairrão, Elisa
name: Verde, Ignacio
name: Barroso, Carlos M.
name: Sousa, Ana C. A.
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: O tributilestanho (TBT) é um contaminante ambiental com uma distribuição à escala mundial, considerado como um dos mais potentes disruptores endócrinos, sendo também considerado como um composto obesogénico e imunotóxico. Os seres humanos estão expostos a este e outros compostos orgânicos de estanhos de várias formas, sendo a ingestão de alimentos, especialmente peixe e marisco, e de água da rede pública, vias importantes de exposição. A absorção através da pele, inalação e ingestão de pó doméstico são também vias importantes. Alguns dispositivos médicos tais como válvulas de silicone e implantes mamários, por terem na sua constituição compostos orgânicos de estanho, podem também constituir uma importante via de exposição. Estudos prévios demonstraram que estes compostos afetam a pressão arterial e podem induzir alterações metabólicas em células vasculares. Considerando a prevalência de doenças cardiovasculares é importante compreender melhor como é que os contaminantes ambientais interferem com o sistema cardiovascular. Neste trabalho, uma revisão da literatura disponível sobre os efeitos dos compostos orgânicos de estanho no sistema vascular será realizada. Considerando o número limitado de estudos existentes, pretendemos estudar o efeito do TBT na linha celular A7r5 (linha celular de músculo liso vascular da aorta embrionária obtida a partir de ratos) por forma a elucidar os efeitos vasculares do TBT. A contractilidade das células A7r5 será analisada através da técnica PCSA (Planar Cell Surface Area) e a atividade de canais de cálcio do tipo L irá ser estudada utilizando a configuração whole cell da técnica Patch Clamp. Este será o primeiro estudo sobre o efeito do TBT em células vasculares.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 1 (2016)
Muchówki (Diptera) stwierdzone w czasie XLI Zjazdu  Sekcji Dipterologicznej PTE – Słopnice, Beskid Wyspowy / Flies (Diptera) found during the XLI Meeting of the Dipterological Section  of the Polish Entomological Society – Słopnice, Island Beskids
Creators: name: Żóralski, Robert
name: Syratt, Maksymilian
name: Słomczyński, Kamil
name: Mielczarek, Łukasz
name: Jędro, Magdalena
name: Bystrowski, Cezary
name: Szpila, Krzysztof
name: Woznica, Andrzej Józef
Publisher: name: Polskie Towarzystwo Entomologiczne
Year: 2024
Subjects: Diptera, Dipterological meeting, Dipterological Section, Polish Entomological Society, Słopnice, Beskid Wyspowy Mts, Carpathians, Poland

description: The 15th Dipterological Conference and the XLI Meeting of the Dipterological Section of the Polish Entomological Society was held on April 21st–23rd 2023 in Słopnice, in the Beskid Wyspowy (Island Beskids) in the Polish Carpathians. During this meeting, participants collected or photographed 76 species of flies, identified within 30 families. Among them, a snail-killing species Pherbellia silana Rivosecchi, 1989 (Sciomyzidae) is reported from Poland for the first time. Moreover, two rare species, Dicranota (Paradicranota) mikiana Lackschewitz, 1940 (Pediciidae), and Syrphus nitidifrons Becker, 1921 (Syrphidae) were found. The study area is also home area to Brachypalpus chrysites Egger, 1859, an impressive hoverfly, listed in the Red List of Threatened Species in Poland and in the European Red List of Syrphidae
A Novel Gateway for Visual Exploratory Analysis and Sharing of Survey Data
Creators: name: Zaslavsky, Ilya
name: Side Li
name: Lamont, Stephan
name: Valentine, David
name: Whitenack, Thomas
Publisher: name: figshare
Year: 2017
Subjects: subject: 80501 Distributed and Grid Systems
subject: FOS: Computer and information sciences
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)
subject: Distributed Computing

description: SuAVE (Survey Analysis via Visual Exploration) is a key component of an emerging infrastructure enabling users to publish, share, and collaboratively analyze survey data in natural and social sciences. We discuss SuAVE analytical capabilities, which combine visual, statistical and cartographic analyses, as well as associated tools for publishing surveys, annotating them, and sharing annotations with partners. In addition to presenting this application as a scalable science gateway for survey data of different types, we demonstrate it using the 2015 Science Gateways Institute survey as a sample dataset. The Institute survey was published in SuAVE to make analysis of raw survey data easily accessible, intuitive, and visually attractive, while offering a combination of powerful data exploration tools.
Effects of the human pharmaceutical gemfibrozil on fish Sparus aurata
Creators: name: Barreto, Ângela
name: Luís, Luís
name: Soares, Amadeu
name: Hylland, Ketil
name: Loureiro, Susana
name: Oliveira, Miguel
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: The growing use of pharmaceutical products is becoming a new environmental problem. The occurrence and fate of pharmaceutically active compounds in the aquatic environment has been recognized as one of the emerging issues in environmental chemistry. Blood lipid lowering agents are among the most commonly found drugs in the aquatic environment. Gemfibrozil, one of the most frequently detected pharmaceuticals from this class, may be considered a high priority pharmaceutical on the basis of its consumption, physico-chemical properties, environmental occurrence and persistence. However, little is known about the aquatic toxicity of gemfibrozil. Therefore, short-term exposure of Sparus aurata to dissimilar concentrations of gemfibrozil, including environmentally relevant concentrations was performed and behavioral and biochemical responses were assessed as endpoints.
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 1 (2016)
Evidencing the Value of Australian Science Gateways
Creators: name: MICHELLE BARKER
Publisher: name: figshare
Year: 2017
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: Impact metrics play a key role in evidencing the value of science gateways, and a range of studies are now emerging that demonstrate the significance of science gateways in different ways. This paper examines some of the research approaches that are being utilized in this field, and discusses the value of different approaches in demonstrating different types of outcomes. The paper concludes by examining the Australian context, and reflects on how this is affecting the analytical approaches being employed to measure the impact of Australian-based science gateways.
A Novel Gateway for Visual Exploratory Analysis and Sharing of Survey Data
Creators: name: Zaslavsky, Ilya
name: Side Li
name: Lamont, Stephan
name: Valentine, David
name: Whitenack, Thomas
Publisher: name: figshare
Year: 2016
Subjects: subject: 80501 Distributed and Grid Systems
subject: FOS: Computer and information sciences
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)
subject: Distributed Computing

description: SuAVE (Survey Analysis via Visual Exploration) is a key component of an emerging infrastructure enabling users to publish, share, and collaboratively analyze survey data in natural and social sciences. We discuss SuAVE analytical capabilities, which combine visual, statistical and cartographic analyses, as well as associated tools for publishing surveys, annotating them, and sharing annotations with partners. In addition to presenting this application as a scalable science gateway for survey data of different types, we demonstrate it using the 2015 Science Gateways Institute survey as a sample dataset. The Institute survey was published in SuAVE to make analysis of raw survey data easily accessible, intuitive, and visually attractive, while offering a combination of powerful data exploration tools.
Characterization of the fungal community in indoor air from hospital emergency departments waiting rooms
Creators: name: Amaro, Raquel
name: Vasconcelos, Marta
name: Gomes, Célia
name: Ferreira, Ana
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: A high number of people are admitted at emergency departments of hospitals on a daily basis. At those environments patients can, sometimes, get healthcare-associated infections (HAIs). Since waiting rooms are also shared by patients’ families or accompanying persons and health care professionals, all these individuals are exposed being at risk of getting this type of infection. Hence, it can constitute a public health problem and the study of such environments, particularly on the identification of microorganisms, becomes crucial. [...]
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 1 (2016)
Test
Creators: name: Łukasz Opaliński
Publisher: name: figshare
Year: 2016
Subjects: subject: 80705 Informetrics
subject: FOS: Media and communications
subject: 80706 Librarianship
subject: Library and Information Studies
subject: 80799 Library and Information Studies not elsewhere classified

description: A number of citations of scientific publications which were published in 2015 and earlier. The citations were observed and counted within an empirical study conducted on the basis of the periodicals listed in Appendix 1 (2016).
The RNA Helicase p68 Regulates Transcription by Facilitating Chromatin Remodeling
Creators: name: Carter, Christie
Publisher: name: Georgia State University
Year: 2009

description: P68 is a prototypical member of the DEAD box RNA helicase family.  Implicated in numerous functions such as cell proliferation, cancer metastasis, transcription regulation and pre-mRNA spllicing, p68 is a multifunctional protein whose roles are still not completely understood.  In the studies presented, we found that p68 was an important regulator of numerous cancer related genes.  This study focuses on the cancer related genes Snail and hTERT.  We show that p68 binds to the promoter and a downstream region within each gene, suggesting that p68 operates via the same mechanism with both genes.  We also show that tyrosine phosphorylated p68 is the major player in transcription regulation.  p68 was also discovered to recruit CREB-binding protein to the promoters of these genes as well as aid in the removal of HDAC1 from the promoters; these findings are consistent with chromatin remodeling and active transcription.  Also, we found that p68 phosphorylation level correlates with the expression level of these genes.  Finally, we describe other genes that are potentially regulated by p68 in the same manner, through the use of ChiP-on-chip technology.
Evidencing the Value of Australian Science Gateways
Creators: name: MICHELLE BARKER
Publisher: name: figshare
Year: 2016
Subjects: subject: Distributed Computing
subject: FOS: Computer and information sciences
subject: 80501 Distributed and Grid Systems
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)

description: Impact metrics play a key role in evidencing the value of science gateways, and a range of studies are now emerging that demonstrate the significance of science gateways in different ways. This paper examines some of the research approaches that are being utilized in this field, and discusses the value of different approaches in demonstrating different types of outcomes. The paper concludes by examining the Australian context, and reflects on how this is affecting the analytical approaches being employed to measure the impact of Australian-based science gateways.
Comunidade bacteriana associada ao inseto vetor da Doença do Nemátodo do Pinheiro
Creators: name: Alves, Marta
name: Matos, Patrícia
name: Pereira, Anabela
name: Vicente, Cláudia
name: Henriques, Joana
name: Lopes, Helena
name: Mota, Manuel
name: Correia, António
name: Henriques, Isabel
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2016

description: Os insetos do género Monochamus são os vetores de dispersão do nemátodo Bursaphelenchus xylophilus, o agente causador da doença do nemátodo do pinheiro (DNP). A DNP afeta árvores do género Pinus e tem um impacto preocupante nas florestas de pinheiro na Eurásia. Uma vez afetados os pinheiros morrem em menos de um ano. [...]
description: Revista Captar: Ciência e Ambiente para Todos, vol. 6 n.º 1 (2016)
SeedMe2: Data sharing building blocks
Creators: name: Chourasia, Amit
name: Nadeau, David
name: Moreland, John
name: Mishin, Dmitry
name: Norman, Michael
Publisher: name: figshare
Year: 2017
Subjects: subject: 80501 Distributed and Grid Systems
subject: FOS: Computer and information sciences
subject: Applied Computer Science
subject: Computer Software
subject: 80505 Web Technologies (excl. Web Search)
subject: Distributed Computing

description: The need for data sharing and rapid data access has become central with the rise of collaborative research in many disciplines. Several data sharing approaches have emerged for consumer use cases that primarily need an easy way to share files using web browsers. However, these approaches are not well suited to the particular demands of large-scale data sharing for computational research. Whereas consumer approaches primarily support manual user interfaces to add and remove files, the huge number of files that can be generated during and after a large-scale computation job make manual data sharing interfaces impractical. Instead, these tasks require mechanisms that integrate into computation workflows to automatically post files during and after computation jobs. Furthermore, scientific data sharing requires additional metadata and descriptive information that characterizes shared data to record job and compute platform characteristics, input data, job parameters, job completion status, and other record-keeping required to document the trajectory of computational research. Without these features, consumer data sharing approaches are not well suited for computational science.
Venus Equation of Anomaly - Ptolemy's Almagest by Toomer (Gerald J.) (1984) | Type-B (ID n° 372)
Creators: name: Toomer, Gerald J.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Astronomy
Medieval history

description: This is a type B edition: A type-B edition corresponds to a critical edition of several table witnesses:
 it is based on several different editions, themselves based on tables from different primary sources.
 A type-B edition can be based on type-A, type-B or type-C editions.
You can find it on the DISHAS project website from this link: https://dishas.obspm.fr/table-edition/372
description: Source: Ptolemy's Almagest, Toomer (Gerald J.), 1984
Brain Sites Capable of Eliciting Short-Day Responses in the Siberian Hamster
Creators: name: Leitner, Claudia
Publisher: name: Georgia State University
Year: 2009

description: Obesity is America?s fastest growing health threat. Although a primary health risk factor, obesity increases the probability of secondary health consequences such as stroke, diabetes mellitus and heart disease. Siberian hamsters offer a convenient model to study obesity, as they exhibit a photoperiod-driven reversal of obesity during the fall-winter months (i.e., short-days-SD). SD responses in the Siberian hamster, amongst others, include decreased adiposity and gonadal regression. The duration of the dark period is faithfully transmitted into a neuroendocrine melatonin (MEL) signal; that codes seasonal information. The brain communicates with body fat (white adipose tissue- WAT) via the sympathetic nervous system (SNS). The central MEL binding sites, however, necessary for the body fat/lipid mobilization responses during SDs are not precisely known, although melatonin receptor (MEL 1aR) mRNA has been co-localized with sympathetic outflow neurons of WAT in several forebrain areas. This dissertation aims to identify and to characterize the contribution of central sites that are important in seasonal responses in Siberian hamsters. Thus, I asked: Which specific brain sites are both sufficient and necessary to stimulate SD-like decreases in body, WAT and testes mass? Furthermore, I tested if SD-induced decreases in body fat mass are accompanied by increased energy expenditure, specifically brown adipose tissue (BAT) thermogenesis. It is hoped that the identification of brain sites and mechanisms involved in the effortless reversal of obesity in these animals can be applied to treatment opportunities of human obesity.
Delafoy, Guillaume, De la constitution du duché ou Etat souverain de Normandie et des droits, immunités, privilèges, franchises, libertés et prérogatives de ses habitants et citoyens, s.l., 1789
Creators: name: Delafoy, Guillaume
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017

description: Guillaume Delafoy (de Lafoy ou Lafoy), né à Saint-Lô en août 1737, décédé à Rouen en juin 1800, avocat au parlement de Normandie, est l'auteur de plusieurs oeuvres: une Consultation sur les domaines autrefois aliénés en Normandie, De la constitution du duché ou état souverain de Normandie (tous deux visibles sur la BNDN), mais aussi d'un Parallèle des assemblées provinciales établies en Normandie avec l'assemblée des états du duché (sl., 1788) et d'une Addition à ce parallèle (sl., 1788). Ami de David Hoüard, il a probablement collaboré au Dictionnaire analytique, étymologique et historique de la coutume de Normandie dont il a rédigé quelques notices.
description: Source: A copy of Google book https://babel.hathitrust.org/cgi/pt?id=nyp.33433069341562;view=1up;seq=13
https://hdl.handle.net/2027/nyp.33433069341562
description: Relation: vignette : https://www.nakala.fr/data/11280/7c3e5ed8
description: Provenance: Astor, Lexnos and Tilden Foundations, 1904