cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Are Compact High-Velocity Clouds Extragalactic Objects?
Creators: name: Maloney, Philip R.
name: Putman, Mary E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Compact high-velocity clouds (CHVCs) are the most distant of the HVCs in the Local Group model and would have HI volume densities of order 0.0003/cm^3. Clouds with these volume densities and the observed neutral hydrogen column densities will be largely ionized, even if exposed only to the extragalactic ionizing radiation field. Here we examine the implications of this process for models of CHVCs. We have modeled the ionization structure of spherical clouds (with and without dark matter halos) for a large range of densities and sizes, appropriate to CHVCs over the range of suggested distances, exposed to the extragalactic ionizing photon flux. Constant-density cloud models in which the CHVCs are at Local Group distances have total (ionized plus neutral) gas masses roughly 20-30 times larger than the neutral gas masses, implying that the gas mass alone of the observed population of CHVCs is about 40 billion solar masses. With a realistic (10:1) dark matter to gas mass ratio, the total mass in such CHVCs is a significant fraction of the dynamical mass of the Local Group, and their line widths would exceed the observed FWHM. Models with dark matter halos fare even more poorly; they must lie within approximately 200 kpc of the Galaxy. We show that exponential neutral hydrogen column density profiles are a natural consequence of an external source of ionizing photons, and argue that these profiles cannot be used to derive model-independent distances to the CHVCs. These results argue strongly that the CHVCs are not cosmological objects, and are instead associated with the Galactic halo.
description: 30 pages, 14 figures; to appear in The Astrophysical Journal
Establishment of diagnostic criteria for upper urinary tract urothelial carcinoma based on genome-wide DNA methylation analysis
Creators: name: Fujimoto, Mao
name: Arai, Eri
name: Tsumura, Koji
name: Yotani, Takuya
name: Yamada, Yuriko
name: Takahashi, Yoriko
name: Maeshima, Akiko Miyagi
name: Fujimoto, Hiroyuki
name: Teruhiko Yoshida
name: Kanai, Yae
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The aim of this study was to develop a less invasive and accurate diagnostic system for upper urinary tract urothelial carcinoma (UTUC) based on genome-wide DNA methylation profiling. Genome-wide DNA methylation screening was performed using the Infinium HumanMethylation450 BeadChip, and DNA methylation quantification was verified using pyrosequencing. We analysed 26 samples of normal control urothelial tissue (C), an initial cohort of 62 samples (31 samples of non-cancerous urothelium [N] from UTUC patients and 31 samples of the corresponding UTUCs), a validation cohort of 82 samples (41 N and 41 UTUC samples), and 14 samples of urinary bladder urothelial carcinoma (BUC). In the initial cohort, we identified 2,448 CpG sites showing significant differences in DNA methylation levels between both C and UTUC and N and UTUC, but not showing differences between C and N. Among these CpG sites, 10 were located within CpG islands or their shores and shelves included in genomic domains where DNA methylation levels are stably controlled, allowing discrimination of UTUC even from BUC. Receiver operating characteristic curve analysis for discrimination of UTUC from N in these 10 CpG and neighbouring sites (37 diagnostic panels in total) yielded area under the curve values of 0.959–1.000, with a sensitivity and specificity of 86.6–100% and 93.5–100%, respectively. The diagnostic impact was successfully confirmed in the validation cohort. Our criteria were useful for diagnosis of UTUC, regardless of its clinicopathological features. Application of our criteria to voided urine samples will ultimately allow non-invasive DNA methylation diagnosis of UTUC.
Additional file of SMS education for the promotion of diabetes self-management in low & middle income countries: a pilot randomized controlled trial in Egypt
Creators: name: Abaza, Haitham
name: Marschollek, Michael
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file of SMS education for the promotion of diabetes self-management in low & middle income countries: a pilot randomized controlled trial in Egypt
MOESM5 of A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos
Creators: name: Troll, Christopher
name: Kapp, Joshua
name: Rao, Varsha
name: Harkins, Kelly
name: Cole, Charles
name: Naughton, Colin
name: Morgan, Jessica
name: Shapiro, Beth
name: Green, Richard
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Plant Biology

description: Additional file 5: Table S3. Synthetic duplexed oligos sequences. (docx 14â€‰kb)
Model of the tail region of the heliospheric interface
Creators: name: Izmodenov, Vladislav V.
name: Alexashov, Dmitry B.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Physical processes in the tail of the solar wind interaction region with the partially ionized local interstellar medium are investigated in a framework of the self-consistent kinetic-gas dynamic model. It is shown that the charge exchange process of the hydrogen atoms with the plasma protons results in suppression of the gas dynamic instabilities and disappearance the contact discontinuity at sufficiently (~3000 AU) large distances from the Sun. The solar wind plasma temperature decreases and, ultimately, the parameters of the plasma and hydrogen atoms approach to the corresponding parameters of the unperturbed interstellar medium at large heliocentric distances.
description: first version, final version is published in Astronomy Letters vol.29 N.1, pp.58-63, 2003
PREDICTING GROUNDWATER TRADING PARTICIPATION IN THE UPPER REPUBLICAN NATURAL RESOURCE DISTRICT
Creators: name: Juchems, Elizabeth M.
name: Schoengold, Karina
name: Brozovic, Nicholas
name: Juchems, Elizabeth M.
name: Schoengold, Karina
name: Brozovic, Nicholas
Publisher: name: Unknown
Year: 2013
Subjects: Land Economics/Use
Research and Development/Tech Change/Emerging Technologies
Research Methods/ Statistical Methods
Resource /Energy Economics and Policy

description: Previous research on water trading has focused on surface water trading and theoretical approaches to analyzing groundwater trading. Empirical analysis of groundwater trading is a new area of study due in part to the previous lack of recorded usage, trade data and binding constraints on groundwater use by landowners. Groundwater trading can help move water from low-value to high-value areas of use for the benefit of the participating traders and general public. The paper predicts participation in groundwater trading and the directions of trades among participants. Specifically, the paper considers both formal and informal trading of groundwater used for crop irrigation purposes and attempts to identify those characteristics that predict the probability of trade participation and whether an individual is a buyer or seller of groundwater rights. Results from this research indicate a strong desire to participate in trades, but high transactions costs have limited the number of trades that have occurred. Utilizing empirical models improves the accuracy of predicting trade participation and direction, and therefore the accuracy of models of trade effects on water supplies and stream flows used in policy and decision making.
Melissodes (Eumelissodes) mimica
Creators: name: Genaro, Julio A.
name: Franz, Nico M.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Apidae
Melissodes
Melissodes mimica

description: Melissodes (Eumelissodes) mimica (Cresson, 1869)
 GD: Cuba and Hispaniola.
 Recorded from Puerto Rico by Ståhl (1882), Gundlach (1887), and Friese (1902). These records are apparently misidentifications of M. trifasciata.
description: Published as part of Genaro, Julio A. & Franz, Nico M., 2008, The bees of Greater Puerto Rico (Hymenoptera: Apoidea: Anthophila), pp. 1-24 in Insecta Mundi 2008 (40) on page 15, DOI: 10.5281/zenodo.5169664
Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells
Creators: name: Owczarz, Magdalena
name: Połosak, Jacek
name: Domaszewska-Szostek, Anna
name: Kołodziej, Paulina
name: Kuryłowicz, Alina
name: Puzianowska-Kuźnicka, Monika
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in SIRT6 expression in peripheral blood mononuclear cells (PBMCs) of healthy young (n = 55, mean age 27.5 ± 4.4 years), middle-aged (n = 51, 65.4 ± 3.3 years), and long-lived (n = 51, 93.9 ± 3.6 years) humans. In silico analysis was performed using the STRING network. No age-related differences were observed in the percentage of SIRT6 CpG island methylation. However, the age affected the expression of miR-34a-5p, miR-125a-5p, miR-186-5p, miR-342-5p and miR-766-3p (all p SIRT6 mRNA and miR-186-5p (rs = −0.25, p = 0.026), and a positive association was observed with miR-34a-5p (rs = 0.31, p = 0.0055) and miR-181a-2-3p (rs = 0.39, p = 0.0002). SIRT6 mRNA also negatively correlated with the expression of TP53 (rs = −0.41, p = 0.0126) and MYC (rs = −0.35, p = 0.0448). Notably, the expression of several miRNAs and genes was similar in young and long-lived groups but different from the middle-aged group. We conclude that age-related epigenetic changes can affect the expression of SIRT6 in PBMCs and, in this way, possibly influence immunosenescence. Moreover, molecular events could differentiate ‘normal’ ageing from that of long-lived individuals.
Additional file 3 of SMS education for the promotion of diabetes self-management in low & middle income countries: a pilot randomized controlled trial in Egypt
Creators: name: Abaza, Haitham
name: Marschollek, Michael
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: SMS content; the educational SMS messages listed by category and followed by their English translation. (PDF 121 kb)
Exploring Dark Matter, Neutrino mass and flavour anomalies in L_μ-L_τ model
Creators: name: Mohanta, Rukmani
name: Singirala, Shivaramakrishna
name: Sahoo, Suchismita
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate Majorana dark matter in a new variant of $U(1)_{L_μ-L_τ}$ gauge extension of Standard Model, containing three additional neutral fermions $N_{e}, N_μ, N_τ$, along with a $(\bar{3},1,1/3)$ scalar Leptoquark (SLQ) and an inert doublet, to study the phenomenology of dark matter, neutrino mass generation and flavour anomalies on a single platform. The lightest mass eigenstate of the $N_μ, N_τ$ neutral fermions plays the role of dark matter. We compute the WIMP-nucleon cross section in leptoquark portal and the relic density mediated by inert doublet components, leptoquark and the new $Z^{\prime}$ boson. We constrain the parameter space consistent with Planck limit on relic density, PICO-60 and LUX bounds on spin-dependent direct detection cross section. We also discuss about the neutrino mass generation at one-loop level and the viable parameter region to explain current neutrino oscillation data. The $Z^\prime$ gauge boson of extended $U(1)$ symmetry and the SLQ play an important role in settling the known issues of flavor sector.
description: 4 pages, 3 figures, to appear in the Proceedings of TAUP-2019 conference, Toyama, Japan
Magneto-transport and magneto-optical properties of ferromagnetic (III,Mn)V semicondcutors: a review
Creators: name: Sinova, Jairo
name: Jungwirth, T.
name: Cerne, J.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Rapid developments in material research of metallic ferromagnetic (III,Mn)V semiconductors over the past few years have brought a much better understanding of these complex materials. We review here some of the main developments and current understanding of the bulk properties of these systems within the metallic regime, focusing principally on the magneto-transport and magneto-optical properties. Although several theoretical approaches are reviewed, the bulk of the review uses the effective Hamiltonian approach, which has proven useful in describing many of these properties namely in (Ga,Mn)As and (In,Mn)As. The model assumes a ferromagnetic coupling between Mn d-shell local moments mediated by holes in the semiconductor valence band.
description: 19 pages, 11 figures
The Equation of State for Two Flavor QCD at Non-zero Chemical Potential
Creators: name: Allton, C. R.
name: Ejiri, S.
name: Hands, S. J.
name: Kaczmarek, O.
name: Karsch, F.
name: Laermann, E.
name: Schmidt, C.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present results of a simulation of QCD on a 4x16^3 lattice with 2 continuum flavors of p4-improved staggered fermion with mass m/T=0.4. Derivatives of the thermodynamic grand potential with respect to quark chemical potential mu_q up to fourth order are calculated, enabling estimates of the pressure, quark number density and associated susceptibilities as functions of mu_q via Taylor series expansion. Discretisation effects associated with various staggered fermion formulations are discussed in some detail. In addition it is possible to estimate the radius of convergence of the expansion as a function of temperature. We also discuss the calculation of energy and entropy densities which are defined via mixed derivatives of the thermodynamic grand potential with respect to the bare couplings and quark masses.
description: 30 pages, LaTeX2e File, 17 Postscript figures
Additional file 2 of SMS education for the promotion of diabetes self-management in low & middle income countries: a pilot randomized controlled trial in Egypt
Creators: name: Abaza, Haitham
name: Marschollek, Michael
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Instruction booklet and nutrition leaflet; both the instruction booklet and nutrition leaflet as given to patients followed by their English translation. (PDF 860 kb)
MOESM4 of A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos
Creators: name: Troll, Christopher
name: Kapp, Joshua
name: Rao, Varsha
name: Harkins, Kelly
name: Cole, Charles
name: Naughton, Colin
name: Morgan, Jessica
name: Shapiro, Beth
name: Green, Richard
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 4: Figure S2. Standard NGS metrics for merged reads from SRSLY, TaKara SMARTer, and Swift 1S libraries from healthy human cfDNA extracts H-69 and H-81
Biofortification, crop adoption and health information: Impact pathways in Mozambique and Uganda
Creators: name: Brauw, Alan De
name: Eozenou, Patrick
name: Gilligan, Daniel O.
name: Hotz, Christine
name: Kumar, Neha
name: Meenakshi, J.V.
name: Brauw, Alan De
name: Eozenou, Patrick
name: Gilligan, Daniel O.
name: Hotz, Christine
name: Kumar, Neha
name: Meenakshi, J.V.
Publisher: name: Unknown
Year: 2013
Subjects: subject: Agricultural and Food Policy
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: International Development
subject: Productivity Analysis
subject: Biofortification
subject: Impact Evaluation
subject: Randomized Control Trial
subject: Technology Adoption
subject: Program Evaluation
subject: Program Design

description: Biofortification, breeding staple food crops to be dense sources of essential micronutrients, is fast emerging as a strategy to fight micronutrient malnutrition. Large scale biofortification investments are being made in several developing countries, but until recently little rigorous evidence about the impact of these investments has been available. In this paper, we report findings from randomized impact evaluations conducted in both Mozambique and Uganda to study the impact of large-scale pilot projects conducted between 2006 and 2009 to introduce provitamin-A-rich orange-fleshed sweet potato (OFSP) as a strategy to reduce vitamin A deficiency. In both countries, projects randomly assigned interventions of different cost and intensity to distribute OFSP vines, train households to grow OFSP, and disseminate the health benefits of vitamin A. We compare the impact of the interventions within and across the two countries on OFSP adoption, knowledge about vitamin A, and dietary intake of vitamin A by children, and use causal mediation analysis (Imai et al. 2011) to examine the impact pathways on vitamin A consumption. After two years of intervention, in both countries the project led to OFSP adoption rates of 61-68 percent among project households, improved household knowledge about vitamin A, and nearly doubled average dietary intake of vitamin A, with no difference between the more and less intense intervention models. Evidence suggests that vine access played the most important role in explaining the impact on vitamin A consumption in both countries. Consequently, future programs can be designed to have similar impacts at even lower costs
DNA methylation in the promoters of PD-L1, MMP9, ARG1, galectin-9, TIM-3, VISTA and TGF-β genes in HLA-DR– myeloid cells, compared with HLA-DR+ antigen-presenting cells
Creators: name: Saleh, Reem
name: Toor, Salman M.
name: Rowaida Z. Taha
name: Al-Ali, Dana
name: Varun Sasidharan Nair
name: Elkord, Eyad
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses during physiological and pathological conditions. We investigated the role of DNA methylation in regulating the transcription of inhibitory/suppressive molecules in myeloid suppressive cells (identified as CD33+HLA-DR–) in comparison to APCs. We selected a number of immune checkpoints (ICs), IC ligands, and immunosuppressive molecules that have been implicated in MDSC function, including PD-L1, TIM-3, VISTA, galectin-9, TGF-β, ARG1 and MMP9. We examined their mRNA expression levels, and investigated whether DNA methylation regulates their transcription in sorted myeloid cell subpopulations. We found that mRNA levels of PD-L1, TIM-3, TGF-β, ARG1 and MMP9 in CD33+HLA-DR– cells were higher than APCs. However, VISTA and galectin-9 mRNA levels were relatively similar in both myeloid subpopulations. CpG islands in the promoter regions of TGF-β1, TIM-3 and ARG1 were highly unmethylated in CD33+HLA-DR–cells, compared with APCs, suggesting that DNA methylation is one of the key mechanisms, which regulate their expression. However, we did not find differences in the methylation status of PD-L1 and MMP9 between CD33+HLA-DR– and APCs, suggesting that their transcription could be regulated via other genetic and epigenetic mechanisms. The promoter methylation status of VISTA was relatively similar in both myeloid subpopulations. This study provides novel insights into the epigenetic mechanisms, which control the expression of inhibitory/suppressive molecules in circulating CD33+HLA-DR– cells in a steady-state condition, possibly to maintain immune tolerance and haemostasis.
The Kodaira problem for Kähler spaces with vanishing first Chern class
Creators: name: Graf, Patrick
name: Schwald, Martin
Publisher: name: arXiv
Year: 2020
Subjects: subject: Algebraic Geometry (math.AG)
subject: Complex Variables (math.CV)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: Let $X$ be a normal compact Kähler space with klt singularities and torsion canonical bundle. We show that $X$ admits arbitrarily small deformations that are projective varieties if its locally trivial deformation space is smooth. We then prove that this unobstructedness assumption holds in at least three cases: if $X$ has toroidal singularities, if $X$ has finite quotient singularities, and if the second cohomology group of its tangent sheaf vanishes.
description: Final version, to appear in Forum of Mathematics, Sigma
The HI Detection of Low Column Density Clouds and Galaxies
Creators: name: Linder, Suzanne M.
name: Minchin, Robert F.
name: Davies, Jonathan I.
name: Baes, Maarten
name: Evans, Rhodri
name: Roberts, Sarah
name: Sabatini, Sabina
name: Smith, Rodney
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The HIDEEP survey (Minchin et al. 2003) was done in an attempt to find objects having low inferred neutral hydrogen column densities, yet they found a distribution which was strongly peaked at 10^20.65 cm^-2. In an attempt to understand this distribution and similar survey results, we model HI profiles of gas discs and use simple simulations of objects having a wide range of HI properties in the presence of an ionizing background. We find that inferred column density (N_HI^o) values, which are found by averaging total HI masses over some disc area, do not vary strongly with central column density (N_max) for detectable objects, so that even a population having a wide range of N_max values will give rise to a strongly peaked distribution of N_HI^o values. We find that populations of objects, having a wide range of model parameters, give rise to inferred column density distributions around 10^20.6+/-0.3 cm^-2. However, populations of fairly massive objects having a wide range of central column densities work best in reproducing the HIDEEP data, and these populations are also consistent with observed Lyman limit absorber counts. It may be necessary to look two orders of magnitude fainter than HIDEEP limits to detect ionized objects having central column densities <10^20 cm^-2, but the inferred column densities of already detected objects might be lower if their radii could be estimated more accurately.
description: 11 pages, 11 figures, accepted to MNRAS, typos fixed
Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring
Creators: name: Khosbayar Lkhagvadorj
name: Meyer, Karolin F.
name: Verweij, Laura P.
name: Kooistra, Wierd
name: Reinders-Luinge, Marjan
name: Dijkhuizen, Henk W.
name: De Graaf, Inge A. M.
name: Plösch, Torsten
name: Hylkema, Machteld N.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Prenatal smoke exposure (PSE) is a risk factor for nicotine dependence. One susceptibility gene for nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine and nicotine clearance in the liver. Higher activity of the CYP2A6 enzyme is associated with nicotine dependence, but no research has addressed the PSE effects on the CYP2A6 gene or its mouse homologue Cyp2a5. We hypothesized that PSE affects Cyp2a5 promoter methylation, Cyp2a5 mRNA levels, and nicotine metabolism in offspring. We used a smoke-exposed pregnant mouse model. RNA, DNA, and microsomal protein were isolated from liver tissue of foetal, neonatal, and adult offspring. Enzyme activity, Cyp2a5 mRNA levels, and Cyp2a5 methylation status of six CpG sites within the promoter region were analysed via HPLC, RT-PCR, and bisulphite pyrosequencing. Our data show that PSE induced higher cotinine levels in livers of male neonatal and adult offspring compared to controls. PSE-induced cotinine levels in neonates correlated with Cyp2a5 mRNA expression and promoter methylation at CpG-7 and CpG+45. PSE increased methylation in almost all CpG sites in foetal offspring, and this effect persisted at CpG-74 in male neonatal and adult offspring. Our results indicate that male offspring of mothers which were exposed to cigarette smoke during pregnancy have a higher hepatic nicotine metabolism, which could be regulated by DNA methylation. Given the detected persistence into adulthood, extrapolation to the human situation suggests that sons born from smoking mothers could be more susceptible to nicotine dependence later in life.
UV Continuum, Physical Conditions and Filling Factor in Active Galactic Nuclei
Creators: name: Martins, Lucimara P.
name: Viegas, Sueli M.
name: Gruenwald, Ruth
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The narrow line region of active galaxies is formed by gas clouds surrounded by a diluted gas. Standard one-dimensional photoionization models are usually used to model this region in order to reproduce the observed emission lines. Since the narrow line region is not homogeneous, two major types of models are used: (a) those assuming a homogeneous gas distribution and a filling factor less than unity to mimic the presence of the emitting clouds; (b) those based on a composition of single-cloud models combined in order to obtain the observed spectra. The first method is largely used but may induce to misleading conclusions as shown in this paper. The second one is more appropriate, but requires a large number of observed lines in order to limit the number of single models used. After discussing the case of an extragalactic HII region, for which the ionizing radiation spectrum is better known, we show that 1-D models for the narrow line region with a filling factor less than unit do not properly mimic the clumpiness, but just simulates an overall lower density. Multi-cloud models lead to more reliable results. Both models are tested in this paper, using the emission-line spectra of two well-known Seyfert galaxies, NGC 4151 and NGC 1068. It is shown that ionizing radiation spectra with a blue bump cannot be excluded by multi-cloud models, although excluded by Alexander et al. (1999, 2000)using homogeneous models with a filling factor less than unity.
description: 23 pages, 7 figures. Accepted for Publication in ApJ
Predicting Planets in Known Extra-Solar Planetary Systems I: Test Particle Simulations
Creators: name: Barnes, Rory
name: Raymond, Sean N.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent work has suggested that many planetary systems lie near instability. If all systems are near instability, an additional planet must exist in stable regions of well-separated extra-solar planetary systems to push these systems to the edge of stability. We examine the known systems by placing massless test particles in between the planets and integrating for 1-10 million years. We find that some systems, HD168443 and HD74156, eject nearly all test particles within 2 million years. However we find that HD37124, HD38529, and 55Cnc have large contiguous regions in which particles survive for 10 million years. These three systems, therefore, seem the most likely candidates for additional companions. Furthermore HD74156 and HD168443 must be complete and therefore radial velocity surveys should only focus on detecting more distant companions. We also find that several systems show stable regions that only exist at nonzero eccentricities.
description: 8 pages, 6 figures, 2 tables, submitted to ApJ
MPEC 2025-C167 : 2025 CG4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 CG4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Self-supervised Attention Model for Weakly Labeled Audio Event Classification
Creators: name: Kim, Bongjun
name: Ghaffarzadegan, Shabnam
Publisher: name: arXiv
Year: 2019
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Machine Learning (cs.LG)
subject: Sound (cs.SD)
subject: Machine Learning (stat.ML)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: We describe a novel weakly labeled Audio Event Classification approach based on a self-supervised attention model. The weakly labeled framework is used to eliminate the need for expensive data labeling procedure and self-supervised attention is deployed to help a model distinguish between relevant and irrelevant parts of a weakly labeled audio clip in a more effective manner compared to prior attention models. We also propose a highly effective strongly supervised attention model when strong labels are available. This model also serves as an upper bound for the self-supervised model. The performances of the model with self-supervised attention training are comparable to the strongly supervised one which is trained using strong labels. We show that our self-supervised attention method is especially beneficial for short audio events. We achieve 8.8% and 17.6% relative mean average precision improvements over the current state-of-the-art systems for SL-DCASE-17 and balanced AudioSet.
D1.4 Definition of assessment study including test scenarios & metrics, and study initiation package
Creators: name: Lepik, Katrin
name: Norak, Kerli
name: Lotman, Eno-Martin
name: Massik, Mall
name: de zegher, isabelle
Publisher: name: Zenodo
Year: 2024
Subjects: assessment study
Study protocol

description: The AIDAVA prototype will be delivered in 2 generations: Generation 1 in Q3 2024 and Generation 2 in Q2 2026. It will be tested in 4 hospitals and 2 Health Data Intermediaries, with 45 patients respectively per therapeutic area across all sites (90 patients for the 2 therapeutic areas in scope).
This deliverable includes the description of the 4 documents developed to support the execution of this assessment study of the two generations of the AIDAVA prototype in an ELSI compliant way, with a minimum burden for the patients and the sites.
The first document - and the most important one - is the study protocol (Annexe 1); it starts with a synopsis of the study and includes a description of the objectives of the study, the specification of the primary and secondary endpoints, the study schedule with the different activities to take place during the evaluation of the prototype across the 2 generations (including the washout period between the 2 generations), the study population with eligibility criteria, the data points to be collected with associated data collection forms (in RedCap) and the statistical analysis.
Another important document, related to the protocol is the English version of the Study Information Package and Informed Consent Form (Annexe 2) to be translated by each site and provided to patients during the recruitment process.
The third document includes a training plan (Annexe 3) for the patients participating in the evaluation and for the study team. It includes a specification of the different modules and a training program for the participants of the study, based on their role.
The final document is a template Data Sharing agreement (Annexe 4), to be adapted and finalised by each site, including guidance for technical and legal provisions.
The deliverable also includes description of work that was conducted with the help of Health Data Intermediaries (HDI) who helped to identify vendors who would provide a patient app application (to collect Quality of Life information) and a blood pressure medical device to be used during the study; the collected data will be managed by the HDI and provided to AIDAVA for integration in the patient record.
We also provide an overview on the feedback provided by the patients´consultants for the different materials mentioned above, and specify the study design with the schedule of activities as well as the Study Information Package and the Informed Consent Form.
title: 02_1265
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
D1.4 Definition of assessment study including test scenarios & metrics, and study initiation package
Creators: name: Lepik, Katrin
name: Lotman, Eno-Martin
name: Markus, Kreuzthaler
Publisher: name: Zenodo
Year: 2023
Subjects: assessment study
Study protocol

description: The AIDAVA prototype will be delivered in 2 generations: Generation 1 in Q3 2024 and Generation 2 in Q2 2026. It will be tested in 4 hospitals and 2 Health Data Intermediaries, with 45 patients respectively per therapeutic area across all sites (90 patients for the 2 therapeutic areas in scope).
This deliverable includes the description of the 4 documents developed to support the execution of this assessment study of the two generations of the AIDAVA prototype in an ELSI compliant way, with a minimum burden for the patients and the sites.
The first document - and the most important one - is the study protocol (Annexe 1); it starts with a synopsis of the study and includes a description of the objectives of the study, the specification of the primary and secondary endpoints, the study schedule with the different activities to take place during the evaluation of the prototype across the 2 generations (including the washout period between the 2 generations), the study population with eligibility criteria, the data points to be collected with associated data collection forms (in RedCap) and the statistical analysis.
Another important document, related to the protocol is the English version of the Study Information Package and Informed Consent Form (Annexe 2) to be translated by each site and provided to patients during the recruitment process.
The third document includes a training plan (Annexe 3) for the patients participating in the evaluation and for the study team. It includes a specification of the different modules and a training program for the participants of the study, based on their role.
The final document is a template Data Sharing agreement (Annexe 4), to be adapted and finalised by each site, including guidance for technical and legal provisions.
The deliverable also includes description of work that was conducted with the help of Health Data Intermediaries (HDI) who helped to identify vendors who would provide a patient app application (to collect Quality of Life information) and a blood pressure medical device to be used during the study; the collected data will be managed by the HDI and provided to AIDAVA for integration in the patient record.
We also provide an overview on the feedback provided by the patients´consultants for the different materials mentioned above, and specify the study design with the schedule of activities as well as the Study Information Package and the Informed Consent Form.
How market-based water allocation can improve water use efficiency in the Aral Sea basin?
Creators: name: Bekchanov, Maksud
name: Bhaduri, Anik
name: Ringler, Claudia
name: Bekchanov, Maksud
name: Bhaduri, Anik
name: Ringler, Claudia
Publisher: name: Unknown
Year: 2013
Subjects: subject: Agribusiness
subject: International Development
subject: International Relations/Trade
subject: Land Economics/Use
subject: Resource /Energy Economics and Policy
subject: inter-catchment and intra-catchment water trading
subject: transaction costs
subject: hydro-economic model

description: Increasing water demand due to population growth, irrigation expansion, industrial development, and the need for ecosystem improvements under mounting investment costs for developing new water sources calls for the efficient, equitable and sustainable management of water resources. This is particularly essential in the Aral Sea Basin (ASB) where ineffective institutions are the primary reason of intersectoral and inter-state water sharing conflicts and lack of sufficient investments for improving water use efficiency. This study examined market-based water allocation as an alternative option to the traditional administrative allocation to deal with water scarcity issues in the ASB. Potential economic gains of tradable water use rights were analyzed based on a newly constructed integrated hydro-economic river basin management model. The analysis differentiates between inter-catchment and intra-catchment water trading. The former does not consider any restrictions on water trading whereas the latter is based on the assumption that water trading is more likely to happen between neighboring water users located within the same catchment area. The analyses show that compared to fixed water allocation, inter-catchment water trading can improve basin-wide benefits by US$ 373 and US$ 476 million depending on water availability. Similarly, additional gains of US$ 259 to US$ 339 million are estimated under intra-catchment water trading depending on relative water availability. Trading gains are higher under drier conditions. However, water trading carries a series of transaction costs. We find that transaction costs exceeding US$0.05 per m3 of water traded wipe out the economic potential for water trading. Enforcement of the rule of law, infrastructural improvements, participation of representatives of all water stakeholders in decision making processes, and friendly relationships among the riparian countries are suggested as means for reducing transaction costs of water trading contracts.
Hybrid configuration content of heavy S-wave mesons
Creators: name: Burch, Tommy
name: Toussaint, Doug
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We use the non-relativistic expansion of QCD (NRQCD) on the lattice to study the lowest hybrid configuration contribution to the ground state of heavy S-wave mesons. Using lowest-order lattice NRQCD to create the heavy-quark propagators, we form a basis of ``unperturbed'' S-wave and hybrid states. We then apply the lowest-order coupling of the quark spin and chromomagnetic field at an intermediate time slice to create ``mixed'' correlators between the S-wave and hybrid states. From the resulting amplitudes, we extract the off-diagonal element of our two-state Hamiltonian. Diagonalizing this Hamiltonian gives us the admixture of hybrid configuration within the meson ground state. The present effort represents a continuation of previous work: the analysis has been extended to include lattices of varying spacings, source operators having better overlap with the ground states, and the pseudoscalar (along with the vector) channel. Results are presented for bottomonium ($Υ$, $η_b^{}$) using three different sets of quenched lattices. We also show results for charmonium ($J/ψ$, $η_c^{}$) from one lattice set, although we note that the non-relativistic approximation is not expected to be very good in this case.
description: 9 pages, 7 figures, version to appear in Phys Rev D
Additional file of Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
Creators: name: Yinghui Zhang
name: Moerkens, Marja
name: Sreenivasa Ramaiahgari
name: De Bont, Hans
name: Price, Leo
name: Meerman, John
name: Van De Water, Bob
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file of Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
The hypomethylation of imprinted genes in IVF/ICSI placenta samples is associated with concomitant changes in histone modifications
Creators: name: Choux, Cécile
name: Petazzi, Paolo
name: Sanchez-Delgado, Marta
name: Mora, José R. Hernandez
name: Monteagudo, Ana
name: Sagot, Paul
name: Monk, David
name: Fauque, Patricia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences

description: Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated. Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with potential long-term effects, through disrupted epigenetic regulation. We have previously demonstrated that placental DNA methylation was significantly lower after IVF/ICSI than following natural conception at two differentially methylated regions (DMRs) associated with imprinted genes (IGs): H19/IGF2 and KCNQ1OT1. As histone modifications are critical for placental physiology, the aim of this study was to profile permissive and repressive histone marks in placenta biopsies to reveal a better understanding of the epigenetic changes in the context of ART. Utilizing chromatin immunoprecipitation (ChIP) coupled with quantitative PCR, permissive (H3K4me3, H3K4me2, and H3K9ac) and repressive (H3K9me3 and H3K9me2) post-translational histone modifications were quantified. The analyses revealed a significantly higher quantity of H3K4me2 precipitation in the IVF/ICSI group than in the natural conception group for H19/IGF2 and KCNQ1OT1 DMRs (P = 0.016 and 0.003, respectively). Conversely, the quantity of both repressive marks at H19/IGF2 and SNURF DMRs was significantly lower in the IVF/ICSI group than in the natural conception group (P = 0.011 and 0.027 for H19/IGF2; and P = 0.010 and 0.035 for SNURF). These novel findings highlight that DNA hypomethylation at imprinted DMRs following ART is linked with increased permissive/decreased repressive histone marks, altogether promoting a more permissive chromatin conformation. This concomitant change in epigenetic state at IGs at birth might be an important developmental event because of ART manipulations.