cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 4 of “That was one of my most difficult and biggest challenges”: experiences, preconditions and preventive measures of health-oriented leadership in virtual teams – A qualitative study with virtual leaders
Creators: name: Efimov, Ilona
name: Harth, Volker
name: Mache, Stefanie
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Material 4: Interview quotes
DISCURSO PROFERIDO PELO REITOR DA UNL PROFESSOR ANTÓNIO RENDAS NA ATRIBUIÇÃO DO GRAU DE DOUTOR HONORIS CAUSA A LUÍS G. SAMBO
Creators: name: Rendas, António
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
A systematic review of the budget impact analyses for antitumor drugs of lung cancer
Creators: name: L Han
name: X Zhang
name: Wenqi Fu
name: CY Sun
name: XM Zhao
name: LR Zhou
name: GX Liu
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020, The Author(s). Background: Budget impact analyses (BIAs) are used for reimbursement decisions and drug access medical insurance, as a supplement to cost-effectiveness analyses (CEAs). Objectives: We systematically reviewed BIAs for antitumor drugs of lung cancer to provide reference for high-value drug budget impact analyses and decision making. Methods: We conducted a literature search on PubMed, EMbase, The Cochrane Library, China National Knowledge Infrastructure and Wanfang Data Knowledge Service Platform from 2010 to 2019. The methodological indicators and result information of the budget impact analyses were extracted and evaluated for quality. Results: A total of 14 studies on the budget impact for antitumor drugs of lung cancer were included, and the overall quality was good. Half of studies were from developed countries. Nine of the studies were designed using the BIA cost calculation model, and two were simulated using the Markov model Monte Carlo model. From all studies, only 14.3% reported model validation. The budget impact results of the same drug in different countries were inconsistent. Conclusions: Included studies evaluating budget impact analyses for anti-tumor drugs of lung cancer showed variability in the methodological framework for BIAs. The budget impact analyses of high-value drugs need to be more stringent to ensure the accuracy of the parameters, and should provide reliable results based on real data to decision-making departments, which should carefully consider access to lung cancer drugs.
Additional file 1 of From Slow Shifts to Fast Flips: Unraveling problem-based learning group function dynamics
Creators: name: Mellon, Matthew
name: Dunn, Nicholas
name: Azim, Arden
name: Chan, Teresa M.
name: Sibbald, Matthew
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy
Mental Health

description: Supplementary Material 1
title: Journalistische Qualität von Musikkritiken
Creators: name: Griessner, Christoph
Year: 2010

description: Ausgehend von der wahrzunehmenden Konkurrenzsituation zwischen Print- und Online-Medien vergleicht die Magisterarbeit Popmusikkritiken der drei Mediengattungen Tageszeitung, Musikmagazin und Online-Magazin. Es soll untersucht werden, ob aus journalistischer Sicht qualitative Unterschiede zwischen den einzelnen Ausprägungen zu attestieren sind und ob gerade die Online-Medien schon zu den Qualitätsmedien aufschließen konnten. Als zweiter Aspekt soll versucht werden, eine subkulturelle Funktion von Popjournalismus anhand der inhaltsanalytischen Betrachtung nachzuweisen. Als theoretische Basis dienen sowohl Ansätze der kritischen Medientheorie wie auch der Cultural Studies. Basierend auf bisherigen wissenschaftlichen Abhandlungen werden die Themenbereiche Musikkritik, Popjournalismus sowie Subkultur und Identitätsbildung eingegrenzt und ausführlich beschrieben, um eine fundierte Ausgangslage für die abschließende Analyse zu schaffen. Im Rahmen dieser sind 60 Artikel aus sechs unterschiedlichen Medien (pro Gattung ein österreichisches und ein deutsches Exemplar) anhand eines deduktiv wie induktiv gebildeten Kategoriensystems kodiert worden. Anhand der Beantwortung der eingangs aufgestellten Forschungsfragen kommt die Magisterarbeit zu dem Schluss, dass Popmusikkritiken in Tageszeitungen zwar sprachlich wie informationstechnisch tendenziell eine höhere Qualität aufweisen können, sich die Kritiken der drei Medienarten insgesamt aber recht ähnlich gestalten, was Metapherndichte oder vergleichbare Aspekte betrifft. Hervorzuheben sind die sehr positiven Merkmale von Online-Kritiken im Vergleich zu jenen in Printmagazinen. Somit lässt sich doch eine leichte Verschiebung popkultureller Berichterstattung in Richtung des World Wide Web artikulieren, auch was deren qualitative Eigenschaften anbelangt. Eine subkulturelle Funktion von Musikkritiken, ausgelöst etwa durch extrem positive Äußerungen der Kritiker zu einzelnen musikalischen wie gesellschaftlichen Phänomenen, kann bei keinem Medium in signifikantem Ausmaß nachgewiesen werden.
Lecanora fluoroxylina Aptroot & M. F. Souza 2021, sp. nov.
Creators: name: Aptroot, André
name: Souza, Maria Fernanda
name: Spielmann, Adriano Afonso
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Lecanoromycetes
Lecanorales
Lecanoraceae
Lecanora
Lecanora fluoroxylina

description: Lecanora fluoroxylina Aptroot & M.F. Souza, sp. nov.   (Fig. 3)
MYCOBANK. — MB 83948.
 DIAGNOSIS. — Lignicolous Lecanora with extensive thallus of usnic acid colour, apothecia with granularly sorediate margins that are higher than the disk.
 TYPE. — Brazil. Mato Grosso do Sul, Aquidauana, Camisão, alt. 150 m, 20°28’52”S, 55°36’47”W, on wooden fence post, 27. VI.2020, A.Aptroot & M.F. Souza 81401 (holo-, CGMS; iso-, ABL).
 ADDITIONAL MATERIAL STUDIED. — Brazil. Mato Grosso do Sul: Miranda, Salobra, on wooden fence post, 26. VI.2020, A.Aptroot & M.F. Souza 81310a; Campo Grande, UCDB campus, on wooden fence post, 13.III.2020, A.Aptroot & M.F. Souza 80858; Mato Grosso: Cuiaba, Chapada dos Guimarães, on wood, 12-18.IX.2020, M.F. Souza & A.Aptroot 104; Paraná: Antonina, Cacatu, on wood of fence, 17.X.2020, M.F. Souza & A.Aptroot 268 (para-, CGMS). CHEMISTRY. — Thallus and apothecia UV-, C-, P+ yellow-orange, K+ yellow, KC+ yellow. TLC: usnic acid and zeorin.
ETYMOLOGY. — Named after the colour that resembles the fluorescence of lichexanthone, and the occurrence on wood.
ECOLOGY AND DISTRIBUTION. — On wooden poles and fences; so far only known from two states in Brazil, but expected to occur in bordering states and countries.  DESCRIPTION
 Thallus crustose, lignicolous, greyish green (usnic acid colour), smooth to granular, sorediate, without prothallus or rarely surrounded by thin black line. Soralia pale greenish, initially punctiform, later usually a bit higher than the thallus but soon confluent and covering most of the thallus, of thallus colour or colour a bit more saturated. Soredia granular, 25-45 µm. Apothecia often present, sessile, round to usually angular, 0.2-0.7 mm diam., up to 0.3 mm high. Margin of thallus colour, granular sorediate, higher than the disk, c. 0.1 mm wide. Disk flat to somewhat convex, pale ochraceous, with greenish (usnic acid) pruina. Epihymenium a dense mass of small usnic acid crystals that extend downward in streaks into the hymenium. Hypothecium hyaline. Excipulum only with small usnic acid crystals. Ascospores and pycnidia not observed.
description: Published as part of Aptroot, André, Souza, Maria Fernanda & Spielmann, Adriano Afonso, 2021, Two new crustose Cladonia species with strepsilin and other new lichens from the Serra de Maracaju, Mato Grosso do Sul, Brazil, pp. 137-148 in Cryptogamie, Mycologie 20 (8) on pages 143-144, DOI: 10.5252/cryptogamie-mycologie2021v42a8, http://zenodo.org/record/12214676
A comparison of penalised regression methods for informing the selection of predictive markers
Creators: name: CJ Greenwood
name: GJ Youssef
name: P Letcher
name: JA Macdonald
name: LJ Hagg
name: A Sanson
name: McIntosh, Jennifer
name: DM Hutchinson
name: JW Toumbourou
name: M Fuller-Tyszkiewicz
name: Olsson, Craig A
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Greenwood et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Penalised regression methods are a useful atheoretical approach for both developing predictive models and selecting key indicators within an often substantially larger pool of available indicators. In comparison to traditional methods, penalised regression models improve prediction in new data by shrinking the size of coefficients and retaining those with coefficients greater than zero. However, the performance and selection of indicators depends on the specific algorithm implemented. The purpose of this study was to examine the predictive performance and feature (i.e., indicator) selection capability of common penalised logistic regression methods (LASSO, adaptive LASSO, and elastic-net), compared with traditional logistic regression and forward selection methods. Design Data were drawn from the Australian Temperament Project, a multigenerational longitudinal study established in 1983. The analytic sample consisted of 1,292 (707 women) participants. A total of 102 adolescent psychosocial and contextual indicators were available to predict young adult daily smoking. Findings Penalised logistic regression methods showed small improvements in predictive performance over logistic regression and forward selection. However, no single penalised logistic regression model outperformed the others. Elastic-net models selected more indicators than either LASSO or adaptive LASSO. Additionally, more regularised models included fewer indicators, yet had comparable predictive performance. Forward selection methods dismissed many indicators identified as important in the penalised logistic regression models. Conclusions Although overall predictive accuracy was only marginally better with penalised logistic regression methods, benefits were most clear in their capacity to select a manageable subset of indicators. Preference to competing penalised logistic regression methods may therefore be guided by feature selection capability, and thus interpretative considerations, rather than predictive performance alone.
Additional file 2 of From Slow Shifts to Fast Flips: Unraveling problem-based learning group function dynamics
Creators: name: Mellon, Matthew
name: Dunn, Nicholas
name: Azim, Arden
name: Chan, Teresa M.
name: Sibbald, Matthew
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy
Mental Health

description: Supplementary Material 2
Quantification of plasma kynurenine metabolites following one bout of sprint interval exercise
Creators: name: A Trepci
name: S Imbeault
name: Wyckelsma, Victoria
name: H Westerblad
name: S Hermansson
name: DC Andersson
name: F Piehl
name: T Venckunas
name: M Brazaitis
name: S Kamandulis
name: L Brundin
name: S Erhardt
name: L Schwieler
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © The Author(s) 2020. The kynurenine pathway of tryptophan degradation produces several neuroactive metabolites suggested to be involved in a wide variety of diseases and disorders, however, technical challenges in reliably detecting these metabolites hampers cross-comparisons. The main objective of this study was to develop an accurate, robust and precise bioanalytical method for simultaneous quantification of ten plasma kynurenine metabolites. As a secondary aim, we applied this method on blood samples taken from healthy subjects conducting 1 session of sprint interval exercise (SIE). It is well accepted that physical exercise is associated with health benefits and reduces risks of psychiatric illness, diabetes, cancer and cardiovascular disease, but also influences the peripheral and central concentrations of kynurenines. In line with this, we found that in healthy old adults (n = 10; mean age 64 years), levels of kynurenine increased 1 hour (P =.03) after SIE, while kynurenic acid (KYNA) concentrations were elevated after 24 hours (P =.02). In contrast, no significant changes after exercise were seen in young adults (n = 10; mean age 24 years). In conclusion, the described method performs well in reliably detecting all the analyzed metabolites in plasma samples. Furthermore, we also detected an age-dependent effect on the degree by which a single intense training session affects kynurenine metabolite levels.
Additional file 1 of Genetic characterization of bovine coronavirus strain isolated in Inner Mongolia of China
Creators: name: Zhang, Fan
name: Chai, Chunxia
name: Niu, Rui
name: Diao, Yun
name: Zhou, Yanyan
name: Zhang, Jinlong
name: Feng, Lin
name: Yao, Chunming
name: Wu, Youzhi
name: Ma, Yanhua
name: Zan, Xiaohui
name: Wang, Wei
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Breast ultrasound in breast cancer surveillance; incremental cancers found at what cost?
Creators: name: L Bromley
name: J Xu
name: SW Loh
name: G Chew
name: E Lau
name: Yeo, Belinda
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Purpose: To determine the diagnostic parameters of breast ultrasound (US) in the setting of routine radiological surveillance after a diagnosis of breast cancer and evaluate costs of the inclusion of breast US as well as any survival benefit of US detected cases of recurrence in surveillance. Methods: 622 patients underwent breast cancer surgery and follow up at Austin Health from July 2009 to December 2015. Retrospective data analysis was performed to determine; diagnostic parameters, financial costs of US and survival outcomes of US detected cases of recurrence. Results: Patients underwent 1–9 years of breast cancer surveillance, with a median of 4.24 years. 390 (62.7%) patients underwent additional breast US surveillance to mammography. 232 (38.3%) fit criteria for use of additional breast US. 199 abnormal imaging episodes occurred, leading to 16 screen detected-cases of locoregional recurrence. US alone generated 107 abnormal images and found 9 cancers. US had a sensitivity of 44.1%, specificity of 95.2% and positive predictive value of 11.7% in comparison to mammography; 20.6%, 97.4% and 9.9% respectively. US had a biopsy rate of 4.0% and lead to an incremental cancer detection rate of 0.38%. The cost of incremental cancer found was $31,463.72 AUD. Survival outcomes based on method of detection of recurrence were insignificant (p value = 0.71). Conclusions: Breast US has a sensitivity of 44.1% and detected seven recurrences that were mammographically occult. Breast US has a similar PPV to mammography in surveillance. Breast US generated considerable biopsy rates and costs. Survival analysis was not able to detect any benefit of US detected cases of recurrence.
title: Die Personalisierung der politischen Wahlkampfberichterstattung in der italienischen Presse
Creators: name: Manganiello, Paolo
Year: 2010

description: Die vorliegende Arbeit ist ein kommunikationswissenschaftlicher Forschungsbericht zum Thema Personalisierung der Wahlkampfberichterstattung in der italienischen Presse. Der erste Teil setzt sich theoretisch mit den verschiedenen Aspekten und Problematiken des Begriffs der Personalisierung auseinander. Laut der These der Personalisierung können aus der Sicht der Medien zwei Entwicklungen analysiert werden, nämlich eine quantitative, wonach die Berichterstattung zunehmend die Akteure in den Mittelpunkt des politischen Geschehens stellt, und eine qualitative, die die Verdrängung der sachpolitischen Darstellung und Diskussion durch die Persönlichkeitsprofile der Politiker vermutet. Auf dieser Basis wird das Modell der (Dys)Funktionalen Personalisierung für die Analyse der Berichterstattung vorgeschlagen, laut dem es zwei Richtungen der Personalisierung gibt, eine funktionale, bei der die Zunahme von personenzentrierter Berichterstattung die Behandlung der sachpolitischen Thematiken nicht ausschließt, und eine dysfunktionale, die sich hauptsächlich mit dem Privatleben und den persönlichen Eigenschaften von Politikern beschäftigt. Dieses Modell wird als Grundlage für die Analyse der Wahlkampfberichterstattung der italienischen Presse verwendet. Die empirische Untersuchung wurde mittels der Methode der Inhaltsanalyse anhand einer Stichprobe aus den italienischen Tageszeitungen „Corriere della Sera“ und „La Repubblica“ durchgeführt. Die Ergebnisse zeigen, dass die Politiker im Laufe der Zeit immer mehr zu Personifikationen ihrer Parteien werden, so dass sich die Wähler mit ihnen als Träger der jeweiligen Ideale und Werte ihrer Partei identifizieren. Auf der Basis des Modells der (Dys)Funktionalen Personalisierung konnte für die italienische Presse eine quantitative Entwicklung der Berichterstattung festgestellt werden, während für die qualitativen Aspekte eine gleichbleibende Dominanz der Sachpolitik beobachtet wurde, was eine Entwicklung in Richtung der „funktionalen Personalisierung“ bedeutet.
The Biathlon Injury and Illness Surveillance (BIIS) project protocol: A prospective cohort study across two World Cup seasons
Creators: name: J Fitzpatrick
name: Perera, Nirmala
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Introduction Reliably and accurately establishing injury and illness epidemiology in biathletes will provide insight into seasonal changes, provide potential to better embed innovative prevention strategies and advance sports medicine through the provision of effective healthcare to biathletes. The main objective of the Biathlon Injury and Illness Study (BIIS) is to provide the first comprehensive epidemiological profile of injury and illness in biathlon athletes during two consecutive Biathlon World Cup seasons over 2-years. Methods The BIIS study methodology is established in line with the International Olympic Committee (IOC) injury and illness surveillance protocols using a biathlon-specific injury and illness report form. Team medical staff will provide weekly data using injury and illness definitions of any injury or illness that receives medical attention regardless of time loss. Injuries or illness must be diagnosed and reported by a qualified medical professional (eg, team physician, physiotherapist) to ensure accurate and reliable diagnoses. Descriptive statistics will be used to identify the type, body region and nature of the injury or illness and athlete demographics such as age and gender. Summary measures of injury and illnesses per 1000 athlete-days will be calculated whereby the total number of athletes will be multiplied by the number of days in the season to calculate athlete-days. Ethics and Dissemination This study has been approved by the Bellbery Human Research Ethics Committee (HREC reference: 2017-10-757). Results will be published irrespective of negative or positive outcomes and disseminated through different platforms to reach a wide range of stakeholders.
Impact de la qualité des institutions sur la croissance économique : cas de la république centrafricaine
Creators: name: KEZE-KOVOUNGBO, Junior Aristide
Publisher: name: Zenodo
Year: 2024
Subjects: Qualité des institutions ; gouvernance ; croissance économique ; RCA ; MCE.

description: L’objectif de cet article est d’analyser l’impact de la qualité des institutions sur la croissance économique en RCA. A cet effet, un modèle à correction d’erreur a été appliqué sur une période allant de 2002Q1 à 2019Q4. Les résultats de l’estimation montrent qu’à court terme, la qualité des institutions politiques et celle des institutions économiques ont des effets directs et indirects sur la croissance économique. Cependant, sur le long terme, uniquement la qualité des institutions économiques a eu un effet significatif sur celle-ci. Bien que les variables représentatives de la qualité des institutions aient un impact significatif sur la croissance économique, les résultats montrent également qu’il existe d’autres facteurs majeurs qui ont un impact significatif sur celle-ci. Parmi ces derniers figurent la formation brute du capital fixe, les investissements directs étrangers et le soutien public au développement. De plus, la croissance économique n’est pas influencée ni par le capital humain ni par le capital naturel. Les résultats exhortent les autorités centrafricaines à instaurer des institutions politiques et économiques inclusives, tout en les incitant à entreprendre des réformes macroéconomiques. Ces dernières impliquent la mise en place de stratégies économiques destinées à préserver la stabilité macroéconomique pour exploiter au mieux leur potentiel économique.
Scoping review of pharmacy-based initiatives for preventing unintended pregnancy: Protocol
Creators: name: Buckingham, Philippa
name: Amos, Natalie
name: Hussainy, SY
name: Mazza, D
Publisher: name: La Trobe
Year: 2023

description: © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Due to a high global incidence of unintended pregnancy, finding novel ways to increase the accessibility of contraceptive products and information is critical. One proposed strategy is to use the accessibility of community pharmacies and expand the role of pharmacists to deliver these services. This protocol reports the methods of a proposed scoping review of pharmacy-based initiatives for preventing unintended pregnancy. We intend to identify the range of interventions employed by pharmacists worldwide and their outcomes and aim to infer the value of task sharing for reducing certain access and equity barriers to contraception. Methods and analysis This protocol was developed with guidance from the Joanna Briggs Institute Methodology for Scoping Reviews. Reporting is compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocols. The scoping review will be reported according to the PRISMA Extension for Scoping Reviews. Seven electronic databases (PubMed, Ovid Medline, Embase, Cochrane Library, Scopus and Cumulative Index to Nursing and Allied Health Literature) were systematically searched for relevant literature published in English from 2000, on 22 August 2019. Two authors will individually screen articles for eligibility in Covidence and data will be charted and reported using a tool developed for the purpose of this review. Ethics and dissemination Findings will be disseminated in publications and presentations with relevant stakeholders. Ethical approval is not required as we will be using data from publicly available literature sources. We will map available evidence across the breadth of studies that have been conducted and identify the effectiveness and acceptability of interventions.
Scoping review of pharmacy-based initiatives for preventing unintended pregnancy: Protocol
Creators: name: P Buckingham
name: Amos, Natalie
name: SY Hussainy
name: D Mazza
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Due to a high global incidence of unintended pregnancy, finding novel ways to increase the accessibility of contraceptive products and information is critical. One proposed strategy is to use the accessibility of community pharmacies and expand the role of pharmacists to deliver these services. This protocol reports the methods of a proposed scoping review of pharmacy-based initiatives for preventing unintended pregnancy. We intend to identify the range of interventions employed by pharmacists worldwide and their outcomes and aim to infer the value of task sharing for reducing certain access and equity barriers to contraception. Methods and analysis This protocol was developed with guidance from the Joanna Briggs Institute Methodology for Scoping Reviews. Reporting is compliant with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocols. The scoping review will be reported according to the PRISMA Extension for Scoping Reviews. Seven electronic databases (PubMed, Ovid Medline, Embase, Cochrane Library, Scopus and Cumulative Index to Nursing and Allied Health Literature) were systematically searched for relevant literature published in English from 2000, on 22 August 2019. Two authors will individually screen articles for eligibility in Covidence and data will be charted and reported using a tool developed for the purpose of this review. Ethics and dissemination Findings will be disseminated in publications and presentations with relevant stakeholders. Ethical approval is not required as we will be using data from publicly available literature sources. We will map available evidence across the breadth of studies that have been conducted and identify the effectiveness and acceptability of interventions.
Additional file 2 of Genetic characterization of bovine coronavirus strain isolated in Inner Mongolia of China
Creators: name: Zhang, Fan
name: Chai, Chunxia
name: Niu, Rui
name: Diao, Yun
name: Zhou, Yanyan
name: Zhang, Jinlong
name: Feng, Lin
name: Yao, Chunming
name: Wu, Youzhi
name: Ma, Yanhua
name: Zan, Xiaohui
name: Wang, Wei
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 2
O ENSINO DAS CIÊNCIAS BIOMÉDICAS NO INSTITUTO DE HIGIENE E MEDICINA TROPICAL
Creators: name: Afonso Grácio, Maria Amélia
name: Dos Santos Grácio, António José
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: É aqui apresentada uma nota breve sobre a fundação da Escola de Medicina Tropical, em 1902, e sua evolução, bem como uma síntese hist órica sobre o ensino das Ciências Biomédicas no ”Inst it ut o de Higiene e Medicina Tropical – Lisboa”.
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
O ENSINO EM SAÚDE PÚBLICA NO INSTITUTO DE HIGIENE E MEDICINA TROPICAL DE LISBOA, 1902-2012
Creators: name: Ferrinho, Paulo
name: Dias, Sónia
name: Hartz, Zulmira
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: Este art igo apresenta uma descrição sumária da longa t radição e evolução do ensino da Saúde Pública no Inst ituto de Higiene e Medicina Tropical (IHMT), que emergiram de uma at ividade integrada da oferta docente da Escola de Medicina Tropical e dos inst itutos que se lhe seguiram. Essa oferta colaborat iva manteve-se ao longo de mais de um século e mult iplicou-se numa at ividade docente em saúde pública alicerçada numa forte agenda de invest igação, que foi crescendo at ravés da realização de cursos para programas de mest rado e doutoramento, bem como de uma forte oferta de cursos de apoio ao desenvolvimento, orientados para a saúde pública como ação colet iva para desenvolver as condições que permitem uma vida saudável no seio das comunidades em que vivemos. Esta ação coletiva está implicada naquilo que a saúde pública faz melhor: a medição do estado de saúde, a organização e gestão de serviços e programas de saúde, o desenvolvimento de recursos humanos em saúde, a promoção da saúde e a intervenção em grupos populacionais específicos. O grupo mult idisciplinar de docentes e invest igadores de saúde pública do IHMT tem assumido protagonismo não só no t rabalho desenvolvido sobre problemát icas prioritárias de saúde, mas também na influência nas polít icas de saúde, no contexto português e internacional, em especial em vários países africanos (Angola, Cabo Verde, Guiné-Bissau e Moçambique), bem como nas organizações internacionais, nomeadamente a União Europeia, a OMS (único Cent ro colaborador da OMS em Portugal para polít icas e planeamento da força de t rabalho em saúde), Banco Mundial e CPLP.
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
Wave interaction and overwash with a flexible plate by smoothed particle hydrodynamics
Creators: name: T Tran-Duc
name: MH Meylan
name: N Thamwattana
name: Bishnu Lamichhane
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The motion of a flexible elastic plate under wave action is simulated, and the well–known phenomena of overwash is investigated. The fluid motion is modelled by smoothed particle hydrodynamics, a mesh-free solution method which, while computationally demanding, is flexible and able to simulate complex fluid flows. The freely floating plate is modelled using linear thin plate elasticity plus the nonlinear rigid body motions. This assumption limits the elastic plate motion to be small but is valid for many cases both in geophysics and in the laboratory. The principal conclusion is that the inclusion of flexural motion causes significantly less overwash than that which occurs for a rigid plate.
DISCURSO PROFERIDO PELO PROFESSOR JORGE SIMÕES NA ATRIBUIÇÃO DO GRAU DE DOUTOR HONORIS CAUSA A LUÍS GOMES SAMBO
Creators: name: Simões, Jorge
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
DISCURSO PROFERIDO PELO DOUTOR LUÍS GOMES SAMBO NA ATRIBUIÇÃO DO SEU GRAU DE DOUTOR HONORIS CAUSA
Creators: name: Gomes Sambo, Luís
Publisher: name: Anais do Instituto de Higiene e Medicina Tropical
Year: 2018

description: .
description: Anais do Instituto de Higiene e Medicina Tropical, v. 11 (2012): Edição Comemorativa
Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial.
Creators: name: Holland, Anne
name: Corte, Tamera
name: Chambers, Daniel C
name: Palmer, Andrew J
name: Ekström, Magnus Per
name: Glaspole, Ian
name: Goh, Nicole SL
name: Hepworth, Graham
name: Yet H Khor
name: Hoffman, Mariana
name: Vlahos, Ross
name: Sköld, Magnus
name: Dowman, Leona
name: Troy, Lauren K
name: Prasad, Jyotika D
name: Walsh, James
name: McDonald, Christine F
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: IntroductionInterstitial lung diseases are characterised by scarring of lung tissue that leads to reduced transfer of oxygen into the blood, decreased exercise capacity and premature death. Ambulatory oxygen therapy may be used to treat exertional oxyhaemoglobin desaturation, but there is little evidence to support its efficacy and there is wide variation in clinical practice. This study aims to compare the clinical efficacy and cost-effectiveness of ambulatory oxygen versus ambulatory air in people with fibrotic interstitial lung disease and exertional desaturation.Methods and analysisA randomised, controlled trial with blinding of participants, clinicians and researchers will be conducted at trial sites in Australia and Sweden. Eligible participants will be randomised 1:1 into two groups. Intervention participants will receive ambulatory oxygen therapy using a portable oxygen concentrator (POC) during daily activities and control participants will use an identical POC modified to deliver air. Outcomes will be assessed at baseline, 3 months and 6 months. The primary outcome is change in physical activity measured by number of steps per day using a physical activity monitor (StepWatch). Secondary outcomes are functional capacity (6-minute walk distance), health-related quality of life (St George Respiratory Questionnaire, EQ-5D-5L and King's Brief Interstitial Lung Disease Questionnaire), breathlessness (Dyspnoea-12), fatigue (Fatigue Severity Scale), anxiety and depression (Hospital Anxiety and Depression Scale), physical activity level (GENEActive), oxygen saturation in daily life, POC usage, and plasma markers of skeletal muscle metabolism, systematic inflammation and oxidative stress. A cost-effectiveness evaluation will also be undertaken.Ethics and disseminationEthical approval has been granted in Australia by Alfred Hospital Human Research Ethics Committee (HREC/18/Alfred/42) with governance approval at all Australian sites, and in Sweden (Lund Dnr: 2019-02963). The results will be published in peer-reviewed scientific journals, presented at conferences and disseminated to consumers in publications for lay audiences.Trial registration numberClinicalTrials.gov Registry (NCT03737409).
20 Years of Olympic Media Research: Trends and Future Directions.
Creators: name: Geurin, Andrea N
name: Naraine, Michael
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The Olympic Games is the largest multisport event in the world, regularly drawing global audiences in the billions to watch coverage of athletes from hundreds of nations. It has received a great deal of scholarly attention, especially in terms of media coverage, consumption, and co-creation. As coverage has the ability to impact media consumers' perceptions of nations, cultures, and issues, it is important to develop an understanding of research trends relating to the Olympic Games and media in order to uncover gaps in the literature which may be filled by future scholarly work. Therefore, in order to highlight trends in the established literature and uncover areas for development, a systematic literature review was conducted to examine the state of Olympic media research over a 20-year time period (1999-2018). A total of 221 articles were examined, revealing insights into the types of research being produced from theoretical, methodological, and contextual perspectives. Results revealed a significant proportion of scholarship focused on the Summer Olympic Games, the United States, newspaper accounts of the Games, and utilized media framing and agenda setting frameworks and the content analysis methodology. Just over half of the studies utilized a theoretical or conceptual framework, the prevalence of which increased over time. Core areas for continued development in the Olympic media space include embracing and grounding research in theory, diversification in research context, and expanding upon the definition of the Olympic Games within the greater Olympic Movement.
Barriers and enablers to the implementation of protocol-based imaging in pancreatic cancer: A qualitative study using the theoretical domains framework.
Creators: name: Ashika D Maharaj
name: Evans, Sue M
name: Zalcberg, John R
name: Ioannou, Liane J
name: Graco, Marnie
name: Croagh, Daniel
name: Pilgrim, Charles HC
name: Dodson, Theresa
name: Goldstein, David
name: Philip, Jennifer
name: Kench, James G
name: Merrett, Neil D
name: Neale, Rachel E
name: White, Kate
name: Evans, Peter
name: Leong, Trevor
name: Green, Sally E
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: BackgroundAccurate pre-operative imaging plays a vital role in patient selection for surgery and in allocating stage-appropriate therapies to patients diagnosed with pancreatic cancer (PC). This study aims to: (1) understand the current diagnosis and staging practices for PC; and (2) explore the factors (barriers and enablers) that influence the use of a pancreatic protocol computed tomography (PPCT) or magnetic resonance imaging (MRI) to confirm diagnosis and/or accurately stage PC.MethodsSemi-structured interviews were conducted with radiologists, surgeons, gastroenterologists, medical and radiation oncologists from the states of New South Wales (NSW) and Victoria, Australia. Interviews were conducted either in person or via video conferencing. All interviews were recorded, transcribed verbatim, de-identified and data were thematically coded according to the 12 domains explored within the Theoretical Domains Framework (TDF). Common belief statements were generated to compare the variation between participant responses.FindingsIn total, 21 clinicians (5 radiologists, 10 surgeons, 2 gastroenterologists, 4 medical and radiation oncologists) were interviewed over a four-month-period. Belief statements relevant to the TDF domains were generated. Across the 11 relevant domains, 20 themes and 30 specific beliefs were identified. All TDF domains, with the exception of social influences were identified by participants as relevant to protocol-based imaging using either a PPCT or MRI, with the domains of knowledge, skills and environmental context and resources being offered by most participants as being relevant in influencing their decisions.ConclusionsTo maximise outcomes and personalise therapy it is imperative that diagnosis and staging investigations using the most appropriate imaging modalities are conducted in a timely, efficient and effective manner. The results provide an understanding of specialists' opinion and behaviour in relation to a PPCT or MRI and should be used to inform the design of future interventions to improve compliance with this practice.
(Re)Defining the proline-rich antimicrobial peptide family and the identification of putative new members
Creators: name: Welch, Nicholas
name: Li, Wenyi
name: Hossain, MA
name: Separovic, F
name: O'Brien-Simpson, NM
name: Wade, JD
Publisher: name: La Trobe
Year: 2023

description: © Copyright © 2020 Welch, Li, Hossain, Separovic, O'Brien-Simpson and Wade. As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AMPs) represent a promising class of compounds to help address this global issue. AMPs are best-known for their membrane-disruptive mode of action leading to bacteria cell lysis and death. However, many AMPs are also known to be non-lytic and have intracellular modes of action. Proline-rich AMPs (PrAMPs) are one such class, that are generally membrane permeable and inhibit protein synthesis leading to a bactericidal outcome. PrAMPs are highly effective against Gram-negative bacteria and yet show very low toxicity against eukaryotic cells. Here, we review both the PrAMP family and the past and current definitions for this class of peptides. Computational analysis of known AMPs within the DRAMP database (http://dramp.cpu-bioinfor.org/) and assessment of their PrAMP-like properties have led us to develop a revised definition of the PrAMP class. As a result, we subsequently identified a number of unknown and unclassified peptides containing motifs of striking similarity to known PrAMP-based DnaK inhibitors and propose a series of new sequences for experimental evaluation and subsequent addition to the PrAMP family.
(Re)Defining the proline-rich antimicrobial peptide family and the identification of putative new members
Creators: name: Welch, Nicholas
name: W Li
name: MA Hossain
name: F Separovic
name: NM O'Brien-Simpson
name: JD Wade
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © Copyright © 2020 Welch, Li, Hossain, Separovic, O'Brien-Simpson and Wade. As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AMPs) represent a promising class of compounds to help address this global issue. AMPs are best-known for their membrane-disruptive mode of action leading to bacteria cell lysis and death. However, many AMPs are also known to be non-lytic and have intracellular modes of action. Proline-rich AMPs (PrAMPs) are one such class, that are generally membrane permeable and inhibit protein synthesis leading to a bactericidal outcome. PrAMPs are highly effective against Gram-negative bacteria and yet show very low toxicity against eukaryotic cells. Here, we review both the PrAMP family and the past and current definitions for this class of peptides. Computational analysis of known AMPs within the DRAMP database (http://dramp.cpu-bioinfor.org/) and assessment of their PrAMP-like properties have led us to develop a revised definition of the PrAMP class. As a result, we subsequently identified a number of unknown and unclassified peptides containing motifs of striking similarity to known PrAMP-based DnaK inhibitors and propose a series of new sequences for experimental evaluation and subsequent addition to the PrAMP family.
Claviradulomyces caseariae L. L. Duarte, D. M. Macedo & R. W. Barreto 2021, sp. nov.
Creators: name: Duarte, Lidiane Leal
name: M, Davi
name: Macedo, esquita de
name: Barreto, Robert Weingart
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Lecanoromycetes
Ostropales
Odontotremataceae
Claviradulomyces
Claviradulomyces caseariae

description: Claviradulomyces caseariae L.L.Duarte, D.M.Macedo & R.W.Barreto, sp. nov.   (Fig. 2)
MYCOBANK NUMBER. — MB 811909.
 HOLOTYPE. — Brazil. State of Minas Gerais, Fervedouro, Refúgio dos Gaudinos, on branches of Casearia ulmifolia Vahl ex. Vent. (Salicaceae), 23. I.2014, R. W.Barreto (VIC 42849, COAD 2348, GenBank LSU sequence MK 931434, rpb 2 sequence MW 191755).
 ETYMOLOGY. — Referring to its host-genus Casearia.
 DIAGNOSIS. — Differing from other species of Claviradulomyces by having septate conidia.
HABITAT AND DISTRIBUTION. — Inside lenticels on branches of a tree growing on the margin of a creek in remnants of the Atlantic tropical rainforest.  DESCRIPTION
 Asexual morph in abnormal hypertophyed lenticels with spongy tissue present on living branches. Conidiomata pycnidial, semi-immersed, isolate, mostly one per lenticel, globose to subglobose 50-70 Μm diam; walls pale brown, textura intrincata at base, changing into olivaceous to light brown textura angularis in the upper half, ostiolate, rostrate; neck subulate 50-105 Μm long and c. 20 Μm diam, walls pale brown, textura porrecta, ending in a short, narrower tip of bristle-like hyphae, smooth. Conidiophores normally reduced to conidiogenous cells, hyaline, suboblate to somewhat lageniform, straight to slightly curved, (-10) 12.5-15 × 2.5 Μm, 0-1 septate, hyaline, smooth. Conidiogenous cells hyaline, holoblastic and smooth. Conidia fusoid-filiform to narrowly acerose, 14.5-30 × 1.5-2.5 Μm, attenuated toward the ends, apex rounded, base subtruncate, guttulate, 0-2 septate, guttulate, hyaline, smooth. Sexual morph not observed.    Culture characteristics
Very slow growing (2.2-3.9 cm diam after 40 days), colonies dry, flat or effuse, slightly depressed, with lobed or entire margins, aerial mycelium scarce and immersed at periphery; pale purplish grey, pigmenting the medium; ending with a white periphery; not sporulating.  NOTES
 Claviradulomyces caseariae sp. nov. has the most divergent morphology among the old and newly described species for of Claviradulomyces in terms of its asexual stage. It has larger conidiophores, (-10) 12.5-15 × 2.5 Μm, and is the only species described until now having septate conidia.
description: Published as part of Duarte, Lidiane Leal, M, Davi, Macedo, esquita de & Barreto, Robert Weingart, 2021, Cryptic but ubiquitous: Claviradulomyceae fam. nov. with five novel species of the lenticel fungus Claviradulomyces from Brazil, pp. 121-135 in Cryptogamie, Mycologie 20 (7) on page 125, DOI: 10.5252/cryptogamie-mycologie2021v42a7, http://zenodo.org/record/12214713
Out of sight, out of mind: long-term outcomes for people discharged home, to inpatient rehabilitation and to residential aged care after stroke
Creators: name: EA Lynch
name: AS Labberton
name: J Kim
name: MF Kilkenny
name: NE Andrew
name: Lannin, Natasha
name: R Grimley
name: SG Faux
name: DA Cadilhac
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Purpose: The aim of this study was to describe differences in long-term outcomes for patients discharged to inpatient rehabilitation facilities (IRFs) following stroke compared to patients discharged directly home or to residential aged care facilities (RACFs). Materials and methods: Cohort study. Data from the Australian Stroke Clinical Registry were linked to hospital admissions records and the national death index. Main outcomes: death and hospital readmissions up to 12 months post-admission, Health-related Quality of Life (HRQoL) 90-180 days post-admission. Results: Of 8,555 included patients (median age 75, 55% male, 83% ischemic stroke), 4,405 (51.5%) were discharged home, 3,442 (40.2%) to IRFs, and 708 (8.3%) to RACFs. No between-group differences were observed in hazard of death between patients discharged to IRFs versus home. Fewer patients discharged to IRFs were readmitted to hospital within 90, 180 or 365-days compared to patients discharged home (adjusted subhazard ratio [aSHR]:90-days 0.54, 95%CI 0.49, 0.61; aSHR:180-days 0.74, 95%CI 0.67, 0.82; aSHR:365-days 0.85, 95%CI 0.78, 0.93). Fewer patients discharged to IRFs reported problems with mobility compared to those discharged home (adjusted OR 0.54, 95%CI 0.47, 0.63), or to RACFs (aOR 0.35, 95%CI 0.25, 0.48). Overall HRQoL between 90-180 days was worse for people discharged to IRFs versus those discharged home and better than those discharged to RACFs. Conclusions: Several long-term outcomes differed significantly for patients discharged to different settings after stroke. Patients discharged to IRFs reported some better outcomes than people discharge directly home despite having markers of more severe stroke.Implications for rehabilitation People with mild strokes are usually discharged directly home, people with moderate severity strokes to inpatient rehabilitation, and people with very severe strokes are usually discharged to residential aged care facilities. People discharged to inpatient rehabilitation reported fewer problems with mobility and had a reduced risk of hospital readmission in the first year post-stroke compared to people discharged directly home after stroke. The median self-reported health-related quality of life for people discharged to residential aged care equated to ‘worst health state imaginable’.