cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Deletions of exons with regulatory activity at the DYNC1I1 locus are associated with split-hand/split-foot malformation
title: array CGH screening of 134 unrelated families
titleType: Subtitle
Creators: name: Tayebi, Naeimeh
name: Jamsheer, Aleksander
name: Flöttmann, Ricarda
name: Sowinska-Seidler, Anna
name: Doelken, Sandra C.
name: Oehl-Jaschkowitz, Barbara
name: Hülsemann, Wiebke
name: Habenicht, Rolf
name: Klopocki, Eva
name: Mundlos, Stefan
name: Spielmann, Malte
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: SHFM
subject: DLX5/6
subject: DYNC1I1
subject: Regulatory Mutations
subject: eExons
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background A growing number of non-coding regulatory mutations are being identified in congenital disease. Very recently also some exons of protein coding genes have been identified to act as tissue specific enhancer elements and were therefore termed exonic enhancers or “eExons”. Methods We screened a cohort of 134 unrelated families with split-hand/split-foot malformation (SHFM) with high resolution array CGH for CNVs with regulatory potential. Results In three families with an autosomal dominant non-syndromic SHFM phenotype we detected microdeletions encompassing the exonic enhancer (eExons) 15 and 17 of DYNC1I1. In a fourth family, who had hearing loss in addition to SHFM, we found a larger deletion of 510 kb including the eExons of DYNC1I1 and, in addition, the human brain enhancer hs1642. Exons 15 and 17 of DYNC1I1 are known to act as tissue specific limb enhancers of DLX5/6, two genes that have been shown to be associated with SHFM in mice. In our cohort of 134 unrelated families with SHFM, deletions of the eExons of DYNC1I1 account for approximately 3% of the cases, while 17p13.3 duplications were identified in 13% of the families, 10q24 duplications in 12%, and TP63 mutations were detected in 4%. Conclusions We reduce the minimal critical region for SHFM1 to 78 kb. Hearing loss, however, appears to be associated with deletions of a more telomeric region encompassing the brain enhancer element hs1642. Thus, SHFM1 as well as hearing loss at the same locus are caused by deletion of regulatory elements. Deletions of the exons with regulatory potential of DYNC1I1 are an example of the emerging role of exonic enhancer elements and their implications in congenital malformation syndromes.
The influence of genetic polymorphisms and natural health products on drug metabolism
Creators: name: Chauhan, Bobby
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Biology, Molecular.

description: The activities of two major components involved in drug metabolism, P-glycoprotein (P-gp) and members of the cytochrome P450 oxidase (CYP) family were studied. This investigation specifically examined the influence of polymorphisms within the ABCB1 gene on P-gp efflux activity and expression. Additionally, the role of natural health products (NHPs) on the activity of both P-gp and members of the CYP3A subfamily was also studied. Findings from this study suggest that the haplotype relationship of C3435T, G2677A/T and C1236T within the ABCB1 gene does not influence P-gp efflux activity or expression. Furthermore, some commonly consumed NHPs, including trans-beta-carotene, Arctostaphylos uva-ursi L. (Kinnikinnick), Acorus americanus Raf. and Acorus calamus L. (Acorus), Curcuma longa L. (turmeric powder), Capsicum annuum L. (chilli powder) and Piper nigrum L. (black pepper), are able to influence the activity of P-gp and members of the CYP3A subfamily in vitro. The results suggest that in order for conventional drug therapy to he effective, the genotype of an individual in relation to drug metabolism, as well as the influence of concomitantly consumed NHPs, should be considered in determining how the bioavailability of therapeutic drugs are influenced.
First test of Verlinde's theory of emergent gravity using weak gravitational lensing measurements
Creators: name: Brouwer, Margot M.
name: Visser, Manus R.
name: Dvornik, Andrej
name: Hoekstra, Henk
name: Kuijken, Konrad
name: Valentijn, Edwin A.
name: Bilicki, Maciej
name: Blake, Chris
name: Brough, Sarah
name: Buddelmeijer, Hugo
name: Erben, Thomas
name: Heymans, Catherine
name: Hildebrandt, Hendrik
name: Holwerda, Benne W.
name: Hopkins, Andrew M.
name: Klaes, Dominik
name: Liske, Jochen
name: Loveday, Jon
name: McFarland, John
name: Nakajima, Reiko
name: Sifón, Cristóbal
name: Taylor, Edward
Publisher: name: Swinburne
Year: 2024

description: Verlinde proposed that the observed excess gravity in galaxies and clusters is the consequence of emergent gravity (EG). In this theory, the standard gravitational laws are modified on galactic and larger scales due to the displacement of dark energy by baryonic matter. EG gives an estimate of the excess gravity (described as an apparent dark matter density) in terms of the baryonic mass distribution and the Hubble parameter. In this work, we present the first test of EG using weak gravitational lensing, within the regime of validity of the current model. Although there is no direct description of lensing and cosmology in EG yet, we can make a reasonable estimate of the expected lensing signal of low-redshift galaxies by assuming a background Lambda cold dark matter cosmology. We measure the (apparent) average surface mass density profiles of 33 613 isolated central galaxies and compare them to those predicted by EG based on the galaxies' baryonic masses. To this end, we employ the similar to 180 deg(2) overlap of the Kilo-Degree Survey with the spectroscopic Galaxy And Mass Assembly survey. We find that the prediction from EG, despite requiring no free parameters, is in good agreement with the observed galaxy-galaxy lensing profiles in four different stellar mass bins. Although this performance is remarkable, this study is only a first step. Further advancements on both the theoretical framework and observational tests of EG are needed before it can be considered a fully developed and solidly tested theory.
Modeling articulated bodies with distributed mass for virtual interactive environments
Creators: name: Delannoy, Jean-Christian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: Dynamic simulation is a powerful application of contemporary computers, it has uses that range from design and manufacturing to simulation and entertainment products. This work investigates dynamic simulation of articulated bodies in interactive virtual environments. Previous techniques for both modeling articulated bodies in virtual environments as well as simulating their motion are qualitatively compared for the twin goals of correctness of results and computational efficiency. Implementations of the Verlet system and the method of stiff springs for articulated bodies are quantitatively compared when used for bodies with segments of varied mass in interactive virtual environments. Finally, a novel adaptation of the Verlet technique for simulating constrained and articulated bodies is presented. Through this adaptation to the Verlet algorithm we are able to simulate bodies with links of inconsistent mass more faithfully than with previous implementations.
EMPOWERING NURSING STUDENTS: EXPLORING SELF-COMPASSION AND SELF-AFFIRMATION FOR MENTAL RESILIENCE
Creators: name: Emiko Taneka, PhD, Taneka, PhD
Publisher: name: continental journal
Year: 2024
Subjects: Japan, nursing profession, burnout, empathy fatigue, self-compassion

description: In Japan, despite the full university enrollment era, there has been a significant increase in the number of universities and nursing schools. This expansion aligns with the rising demand for nurses, amplified by factors like the impact of new coronavirus infections. As of recent records, there are approximately 1.27 million nurses in Japan, as reported by the Japan Nurses Association. However, this increase in numbers does not eliminate the persisting issue of high turnover rates in the nursing profession. One contributing factor is nurses' tendency to internalize others' distress, which often leads to empathy fatigue, secondary stress, and self-negative cognitions. These emotional burdens can culminate in burnout.

This paper emphasizes the importance of self-compassion as a crucial factor in addressing burnout, particularly in scenarios where nurses consistently grapple with empathy fatigue and secondary stress. By examining the dynamics of self-compassion, this study seeks to provide valuable insights into strategies for alleviating the burnout crisis among nurses in Japan.
Crop improvement of the vanilla tree, Vanilla planifolia, using organic fertilizer based on rice straw and manure in Mandritsara-Madagascar
Creators: name: Flora Soarizafy
name: Feno Arthur Rahajason
name: Martial Zozime Rasolonjatovo
name: Ronald Harison Randimbiarivelo
name: Emilienne Rasoanandrasana
Publisher: name: Zenodo
Year: 2024

description: Certain theoretical models have been proposed in this article such as in intensive agriculture which proposes agricultural systems based on a model where the dependence of farmers on agro-food industries in order to improve economic efficiency with the aim of increasing and improving the ecological efficiency. Madagascar vanilla is not only one of the main revenue products, but it is also the national pride of the big island. But currently, this vanilla sector finds itself in a delicate situation due to the lack of quality on world markets. Thus, the objective of this study is to improve the cultivation technique of vanilla using organic fertilizer based on rice straw and manure in order to determine its quality. The adopted methodology focuses on the making of organic fertilizers, cultural tests and laboratory analysis. According to the obtained results, the development of vanilla cultivation showed that intensive agriculture could mobilize certain services linked to good management of biodiversity, particularly at the agronomic level, and making it possible to better reconcile agricultural production and the preservation of nature biodiversity.
The Size Evolution of Star-forming Galaxies since z ∼ 7 Using ZFOURGE
Creators: name: Allen, Rebecca
name: Kacprzak, Glenn
name: Glazebrook, Karl
name: Labbe, Ivo
name: Tran, Kim-Vy H.
name: Spitler, Lee R.
name: Cowley, Michael
name: Nanayakkara, Themiya
name: Papovich, Casey
name: Quadri, Ryan
name: Straatman, Caroline M. S.
name: Tilvi, Vithal
name: van Dokkum, Pieter
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: For the first time, we present the size evolution of a mass-complete (log(M ∗/M o) > 10) sample of star-forming galaxies over redshifts z = 1-7, selected from the FourStar Galaxy Evolution Survey. Observed H-band sizes are measured from the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) Hubble Space Telescope (HST)/F160W imaging. Distributions of individual galaxy masses and sizes illustrate that a clear mass-size relation exists up to z ∼ 7. At z ∼ 7, we find that the average galaxy size from the mass-size relation is more compact at a fixed mass of log(M ∗/M o) = 10.1, with kpc, than at lower redshifts. This is consistent with our results from stacking the same CANDELS HST/F160W imaging, when we correct for galaxy position angle alignment. We find that the size evolution of star-forming galaxies is well fit by a power law of the form kpc, which is consistent with previous works for normal star-formers at 1 < z < 4. In order to compare our slope with those derived Lyman break galaxy studies, we correct for different IMFs and methodology and find a slope of -0.97 ± 0.02, which is shallower than that reported for the evolution of Lyman break galaxies (LBGs) at z > 4 (). Therefore, we conclude the LBGs likely represent a subset of highly star-forming galaxies that exhibit rapid size growth at z > 4.
Revised syntactic attributes for relative cause simplification and relative pronoun correction
Creators: name: George, Christina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, Electronics and Electrical.

description: Using previous work for resolving relative clause attachment ambiguities as a starting point, we expanded an existing framework consisting mainly of semantic features to include new syntactic features. We used these new syntactic attributes on their own, as well as with the existing ones in two separate applications. First, we examined sentences containing restrictive and non-restrictive relative clauses and classified them according to whether the relative clauses could be removed to simplify the sentences. In the second application, we corrected the selection of relative pronouns in French to English machine translations. To test our revised syntactic attributes, we devised a two-stage system. In the first stage, we used binary classification to perform an initial screening of sentences, followed by a more detailed classification in the second stage. We then evaluated the performance of each stage as well as the system as a whole. In each application, we made specific adjustments and succeeded in demonstrating that the combination of syntactic and semantic attributes was more effective in these classification tasks than relying on one type of attribute exclusively.
Tracing the distribution and growth of baryons in the nearby cosmic web
Creators: name: Gurvarinder
Publisher: name: Swinburne
Year: 2024

description: This thesis examined the importance of separating and controlling for large and small-scale environment when investigating the roles of nature versus nurture in the evolution of galaxies in the cosmic web. A key outcome of this work was the characterisation of how differing corrections for redshift distortions can impact the subsequent analysis. Finally, it was shown that high completeness galaxy surveys can reliably disentangle the role of small-scale environment in the assembly of stellar mass within large-scale structures in the Universe.
The mechanism of adsorption of sulfides on gold(111).
Creators: name: Qu, Deyu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Chemistry, Physical.

description: In this thesis, we present the electrochemical and spectroscopic characterization of the monolayer on a Au(111) single crystal formed by alkanethiols, dialkyldisulfides and dialkylsulfides. We found that all these organic sulfur compounds adsorb dissociatively and form a monolayer of thiolates. We also study the monolayer formed by a cyclic sulfide, pentamethylene sulfide. We found that this sulfide forms a monolayer of an aldehyde terminated thiolate. We suggest that the sulfide is oxidatively dissociated by molecular oxygen and adsorb on the gold surface. A mechanism of this process is also described. We use S$\sb{\rm N}$2 chemistry to examine the reactivity of this cyclic sulfide. The fact that an S$\sb{\rm N}$2 reaction occurs on the gold surface proves the formation of a reactive chemisorbed sulfide on the gold surface.
The meaning and implementation of curriculum integration in the middle school years: Ministry of Education reforms and current practice in the Ontario school system.
Creators: name: Clausen, Kurt W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Education, Curriculum and Instruction.

description: While government agencies and numerous education specialists have, for most of this century, tried to promote the use of integrated curricula, the application of this innovation has remained scattered and unfocused. Their lack of agreement concerning its purpose and practicality appears to be a central cause of this problem. With an unclear perception of what this innovation is, many educators find it difficult to implement and resistant to effective and widely-accepted definition and evaluation. The Ontario public school system reflects this problem. The Ministry of Education has directly promoted various forms of curriculum integration in successive stages since 1937. However, each of these initiatives has been followed by a period of retrenchment to disciplinary curricula. A trend emerges from this repeated cycle of advocation, resistance, and then reversal. To many who have implemented this innovation, curriculum integration comes to appear as a worthy endeavour in theory, but inapplicable and unworkable in practice. Nevertheless, its underlying premise, capable of being transferred into a multitude of potential benefits, remains attractive enough that the initiative is repeatedly resurrected. The objective of this thesis is to develop a more precise representation of the dynamics that affect the process of defining and implementing curriculum integration within the framework of the Ontario school system. This will be represented by an examination of both the perspectives of the Ministry, and of school administrators and teachers. This research will be undertaken through a two-phase study, coordinated through a series of innovation profiles (based on the work of Leithwood & Montgomery, 1987; and Scheirer, 1994), and will focus on the "Middle School Years" (grades 7 & 8).
title: Sectoral Checklist for preparation and inspection of a safety report
title: Sectoral Checklist for Safety Reports (Triple C)
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: Industrie
subject: Anlagenbetrieb
subject: Leitfaden
subject: Seveso
subject: Triple C
subject: UNECE
subject: safety report
subject: industrial accident
subject: industrial accidents
subject: safety management
subject: checklist
subject: guideline
subject: Chemikalien
subject: Chemicals

description: Based on the UNECE Convention on the Transboundary Effects of Industrial Accidents and EU Directive 96/82/EC (Seveso II), this sector- and region-specific guideline provides checklists for drawing up and reviewing safety reports. Quelle: Bericht
description: Based on the ⁠UNECE⁠ Convention on the Transboundary Effects of Industrial Accidents and EU Directive 96/82/EC (SEVESO II), this sector- and region-specific guideline provides checklists for drawing up and reviewing safety reports.
Buenoa konta Nieser & Pelli 1994
Creators: name: Santos, Suzane Evaristo Dos
name: Barbosa, Julianna Freires
name: Moreira, Felipe Ferraz Figueiredo
name: Couceiro, Sheyla Regina Marques
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Notonectidae
Buenoa
Buenoa konta

description: Buenoa konta Nieser & Pelli, 1994
(Fig. 39A–B)
Buenoa konta Nieser & Pelli, 1994: 1 (original description)
Distribution. Brazil: Alagoas, Bahia, Ceará (Jordão et al. 2025), Goiás (Barbosa & Dias-Silva 2017), Mato Grosso do Sul (Barbosa et al. 2010a), Minas Gerais (Nieser & Pelli 1994; Nieser & Melo 1997; Melo & Nieser 2004; Barbosa & Rodrigues 2013; Carrenho et al. 2020), Pará (Barbosa et al. 2010a; Barbosa & Nessimian 2013a; present study), Rio de Janeiro (Ribeiro et al. 2010), Sergipe (Jordão et al. 2025).
Distribution in Pará. Canaã dos Carajás (Barbosa et al. 2010a; Barbosa & Nessimian 2013a), Capitão Poço (Barbosa & Nessimian 2013a), Curionópolis (Barbosa et al. 2010a; Barbosa & Nessimian 2013a), Itaituba (present study), Parauapebas (Barbosa et al. 2010a; Barbosa & Nessimian 2013a).
Material examined. Brazil, Pará, Município de Itaituba, Lago São Tomé, 04°15’27” S / 55°58’40” W, 26/ VII/2022, S.E. Santos col. (7 ♂, 5 ♀).
description: Published as part of Santos, Suzane Evaristo Dos, Barbosa, Julianna Freires, Moreira, Felipe Ferraz Figueiredo & Couceiro, Sheyla Regina Marques, 2025, Corixoidea and Notonectidae (Hemiptera: Heteroptera: Nepomorpha) of Pará, Brazil, with new records from the western portion of the state, pp. 275-304 in Zootaxa 5627 (2) on page 288, DOI: 10.11646/zootaxa.5627.2.3, http://zenodo.org/record/15325988
Levels and predictors of urinary nickel concentrations of children in Germany: Results from the German Environmental Survey on children (GerES IV)
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: Human-Biomonitoring
Nickel
Harn
Umwelt-Survey [Bevölkerungsexposition]
Umweltmedizin
Bundesrepublik Deutschland

description: Human biomonitoring of nickel has gained interest in environmental medicine due to its wide distribution in the environment and its allergenic potential. There are indications that the prevalence of nickel sensitization in children is increased by nickel exposure and that oral uptake of nickel can exacerbate nickel dermatitis in nickel-sensitive individuals. Urinary nickel measurement is a good indicator of exposure. However, data on nickel levels in urine of children are rare. For the first time, the German Environmental Survey on children (GerES IV) 2003-2006 provided representative data to describe the internal nickel exposure of children aged 3-14 years in Germany. Nickel was measured after enrichment in the organic phase of urine by graphite furnace atomic absorption spectrometry with Zeeman background correction. Nickel levels (n = 1576) ranged from <0.5 to 15 ĆÊg/l. Geometric mean was 1.26 ĆÊg/l. Multivariate regression analysis showed that gender, age, socio-economic status, being overweighted, consumption of hazelnut spread, nuts, cereals, chocolate and urinary creatinine were significant predictors for urinary nickel excretion of children who do not smoke. 20.2% of the variance could be explained by these variables. With a contribution of 13.8% the urinary creatinine concentration was the most important predictor. No influence of nickel intake via drinking water and second hand smoke exposure was observed.Copyright ©2012 Published by Elsevier GmbH.
The dynamics of transition from high-performance sport.
Creators: name: Sinclair, Dana A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Education, Guidance and Counseling.

description: The purpose of this study was to examine and explore the transition experiences of Canada's high performance athletes within Charner and Schlossberg's (1986) theoretical framework to determine the predisposing factors and effects of the transition process. More specifically, this study investigated the reasons for retirement, the individual coping strategies and support networks used by transitional athletes, as well as other variables that may have impacted on the athlete's adjustment process. This study provided an alternative, comprehensive perspective from which to examine retirement from high performance sport. Retired high performance athletes (N = 199) with international competitive experience completed the Athlete Retirement Questionnaire, a 34-item instrument developed for this study. Multivariate analyses revealed that planned retirement led to smoother adjustment than unplanned retirement. Loglinear analyses indicated that positive adjustment was also related to those transitions which caused the least disruption in the lives of the athletes. Chi-square analyses showed that those athletes who adjusted smoothly tended to retire after they had achieved their sport related goals or because they had achieved their goals in sport. Athletes who were more dissatisfied with their transition tended to feel incompetent outside of sport and tended to feel that keeping busy was not an effective coping strategy. Charner and Schlossberg's transitional framework received support in terms of overall fit, and provided direction for practical intervention suggestions. Finally, this study suggests that adjustment to retirement from high performance sport may not be as distressing or problematic for as many national team athletes as previously thought.
Hybrid Sensing Platform for IoT-based Precision Agriculture
Creators: name: Bagha, Hamid
Publisher: name: Swinburne
Year: 2024

description: Sensing approaches in precision agriculture are typically divided into ground-based and UAV-based aerial sensing each of which have certain advantages and limitations. This research proposes a hybrid sensing platform (HSP) which integrates aerial and ground-based sensing approaches. In HSP the data observation of ground-based nodes is used as ground truth to validate and calibrate the aerial data. Once the aerial data quality is improved, the UAV is used to collect data from the farm zones which are out of ground-based sensors field of view. Such platform reduces the cost of sensors deployment while at the same time increases the data quality and decision making process.
Reduction of phytic acid content in canola meal by solid state fermentation.
Creators: name: Nair, Vipinachandran.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Chemical.

description: Solid state fermentation of canola meal has been carried out for the reduction of its phytic acid content. Several microorganisms were surveyed for this purpose. The phytic acid content of canola meal was reduced by 26%, 60% and 66% using Saccharomyces cerevisiae, Rhizopus oligosporus NRRL 2990 and Aspergillus niger NRC 401121 respectively after 120 hours of fermentation. Aspergillus ficuum NRRL 3135 was found to be the best for the reduction of phytic acid content. For this reason, this microorganism was studied more extensively. In the study of the phytase (EC 3.1.3.8) from Aspergillus ficuum NRRL 3135, it was found that the production of the enzyme in a submerged batch process was inhibited by high concentrations of glucose. The inhibition was overcome by applying a fed batch technique in the production of the enzyme. Tests carried out at different oxygen concentrations revealed that aeration had a beneficial effect on the production of the enzyme. (Abstract shortened by UMI.)
Wide-band profile domain pulsar timing analysis
Creators: name: Lentati, L.
name: Kerr, M.
name: Dai, S.
name: Hobson, M. P.
name: Shannon, Ryan
name: Hobbs, G.
name: Bailes, Matthew
name: Bhat, N. D. Ramesh
name: Burke-Spolaor, S.
name: Coles, W.
name: Dempsey, J.
name: Lasky, P. D.
name: Levin, Y.
name: Manchester, R. N.
name: Oslowski, Stefan
name: Ravi, V.
name: Reardon, Daniel
name: Rosado, P. A.
name: Spiewak, R.
name: van Straten, Willem
name: Toomey, L.
name: Wang, J.
name: Wen, L.
name: You, X.
name: Zhu, X.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 5101
subject: Astronomical sciences
classificationCode: 5109
subject: Space sciences

description: We extend profile domain pulsar timing to incorporate wide-band effects such as frequencydependent profile evolution and broad-band shape variation in the pulse profile. We also incorporate models for temporal variations in both pulse width and in the separation in phase of the main pulse and interpulse. We perform the analysis with both nested sampling and Hamiltonian Monte Carlo methods. In the latter case, we introduce a new parametrization of the posterior that is extremely efficient in the low signal-to-noise regime and can be readily applied to a wide range of scientific problems. We apply this methodology to a series of simulations, and to between seven and nine years of observations for PSRs J1713+0747, J1744-1134 and J1909-3744 with frequency coverage that spans 700-3600 Mhz. We use a smooth model for profile evolution across the full frequency range, and compare smooth and piecewise models for the temporal variations in dispersion measure (DM). We find that the profile domain framework consistently results in improved timing precision compared to the standard analysis paradigm by as much as 40 per cent for timing parameters. Incorporating smoothness in the DM variations into the model further improves timing precision by as much as 30 per cent. For PSR J1713+0747, we also detect pulse shape variation uncorrelated between epochs, which we attribute to variation intrinsic to the pulsar at a level consistent with previously published analyses. Not accounting for this shape variation biases the measured arrival times at the level of ~30 ns, the same order of magnitude as the expected shift due to gravitational waves in the pulsar timing band.
Quantum criticality and optical conductivity in a two-valley system
Creators: name: Gindikin, Yasha
name: Li, Songci
name: Levchenko, Alex
name: Kamenev, Alex
name: Chubukov, Andrey V.
name: Maslov, Dmitrii L.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate that the optical conductivity of a Fermi liquid (FL) in the absence of umklapp scattering is dramatically affected by the topology of the Fermi surface (FS). Specifically, electron-electron (ee) scattering leads to rapid current relaxation in systems with multiple, or multiply connected, FSs, provided the valleys have different effective masses. This effect results from intervalley drag. We microscopically derive the optical conductivity of a two-valley system, both within the FL regime and near a quantum critical point (QCP) of the Ising-nematic type. In the FL regime, intervalley drag restores the Gurzhi-like scaling of the conductivity, $\mathrm{Re} σ(ω) \sim ω^0$. This dependence contrasts sharply with the previously identified sub-leading contribution to the conductivity of a two-dimensional FL with a single convex FS, where $\mathrm{Re} σ(ω) \sim ω^2 \ln |ω|$. The vanishing of the leading term in the optical conductivity is a signature of geometric constraints on ee scattering channels, which are lifted for a multiply connected FS. A large differential response, $d \mathrm{Re} σ/d μ$ with $μ$ being the chemical potential, is predicted at the Lifshitz transition from a single-valley to a multi-valley FS, which should be observable within the experimentally accessible frequency range. Near a QCP, intervalley drag leads to a $|ω|^{-2/3}$ scaling of $\mathrm{Re} σ(ω)$ in 2D, thus providing a specific current-relaxing process for this long-standing conjecture.
description: 18 pages, 3 figures
title: Einsatz von Nanomaterialien in Textilien
title: Datenblatt Nanoprodukte
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: Textilien
subject: Nanomaterialien
subject: Nanotechnik
subject: Nanotechnologie
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Nanotechnologie kann Jacken mehr wasser- und Tischdecken mehr schmutzabweisend machen. Sie kann auch die Umwelt schützen, wenn die Textilien öfter verwendet werden können oder die selbstreinigende Oberflächen sparen Reinigungsmittel. Nanomaterialien sind stabil eingebettet werden, um die Produktqualität und die Funktionalität der Textilien zu erhalten. Dies verhindert auch die Freisetzung von Nanomaterialien mit potenziellen Gefahren für die menschliche Gesundheit und die Umwelt.
Characterization and functional analysis of the bidirectional promoter region of the zebrafish hsp1060 genes
Creators: name: Kamkar, Maryam
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, General.

description: Protein folding in vivo, often requires a set of proteins called chaperones. Chaperones assist the folding of newly synthesized proteins, to obtain their active tri-dimensional structures. They may also provide adaptive response against adverse conditions such as heat shock and stress. Chaperonins 10 and 60 (Hsp10 and Hsp60) are present in the mitochondria of all cells. The Hsp10/60 machinery occurs as a complex with a 2:1 stoichiometry of Hsp10 to Hsp60. hsp10/60 genes are linked in a head-to-head manner with a short intergenic region. To investigate the bidirectionality of the hsp10/60 promoter region, we made a number of reporter constructs and tested them by microinjection into fertilized zebrafish eggs and by transfection of mammalian 293 and zebrafish ZF-4 cells. Our results showed that the promoter region is comprised of a ∼1-kb fragment that encompasses the hsp10 transcription start site, the intergenic region, and the transcription start site of hsp60. A larger fragment of about 4 kb, covering the start codon of both genes, which includes the first exon of hsp10, the first intron of hsp60, and the first two exons of hsp60, directs twice as much expression of reporter genes in the hsp60 direction as compared to the hsp10 direction. This fragment also causes strong expression in the yolk syncytial layer, particularly during the gastrula stage. Deletion of the first intron of hsp60 results in the loss of the 2:1 ratio in expression and the loss of expression in the yolk, suggesting the existence of a cis-acting element within the intronic region. This element may be responsible for maintaining protein concentrations suitable for maintaining normal stoichiometry. A 86-bp region within the first intron of hsp60 seems to include a site that is linked to the expression in the yolk. However, the region responsible for the stronger expression in the hsp60 direction could not be more precisely localized. The hsp10/60 genes show a detectable expression under normal conditions and are inducible by at least two-fold under heat shock conditions. The hsp10/60 promoter could be used as an inducible promoter in transgenic studies especially for simultaneous co-expressions.
title: Hallazgos radiológicos en patologia vascular mesentérica
Creators: name: Nieto Moreno, Patricia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Vascular

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
•Nuestra intención es presentar casos sobre patología vascular mesentérica estudiados con TC multidetector (TCMD) de abdomen con contraste intravenoso.
Esperamos que estas imágenes puedan servir de recordatorio y ayuda para facilitar el...
2dFLenS and KiDS: Determining source redshift distributions with cross-correlations
Creators: name: Johnson, Andrew
name: Blake, Chris
name: Amon, Alexandra
name: Erben, Thomas
name: Glazebrook, Karl
name: Harnois-Deraps, Joachim
name: Heymans, Catherine
name: Hildebrandt, Hendrik
name: Joudaki, Shahab
name: Klaes, Dominik
name: Kuijken, Konrad
name: Lidman, Chris
name: Marin Perucci, Felipe
name: McFarland, John
name: Morrison, Christopher B.
name: Parkinson, David
name: Poole, Gregory B.
name: Radovich, Mario
name: Wolf, Christian
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We develop a statistical estimator to infer the redshift probability distribution of a photometric sample of galaxies from its angular cross-correlation in redshift bins with an overlapping spectroscopic sample. This estimator is a minimum-variance weighted quadratic function of the data: a quadratic estimator. This extends and modifies the methodology presented by McQuinn & White. The derived source redshift distribution is degenerate with the source galaxy bias, which must be constrained via additional assumptions. We apply this estimator to constrain source galaxy redshift distributions in theKilo-Degree imaging survey through crosscorrelation with the spectroscopic 2-degree Field Lensing Survey, presenting results first as a binned step-wise distribution in the range z < 0.8, and then building a continuous distribution using a Gaussian process model. We demonstrate the robustness of our methodology using mock catalogues constructed from N-body simulations, and comparisons with other techniques for inferring the redshift distribution.
D4.4: evBOW products in C. elegans
Creators: name: Bergese, Paolo
name: Di Bucchianico, Sebastiano
name: Di Schiavi, Elia
name: Romano, Miriam
name: Santonicola, Pamela
name: Trapani, Irene
Publisher: name: Zenodo
Year: 2024

description: BOW Project deliverable 4.4: evBOW products in C. elegans
Design and transformation of versatile ruthenium catalysts
Creators: name: Drouin, Samantha D
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Chemistry, Inorganic.

description: Ruthenium metathesis catalyst RuCl2(PCy3) 2(CHPh) (1a) was transformed into hydrogenation-active species via hydrogenolysis of the alkylidene ligand. Several different hydride products were identified, including novel dihydrogen complex RUCl2(H 2)(PCy3)2 (3), and hydridochloro species RuHCl(H2)(PCy3)2 (4). In related work, an optimized protocol for tandem ring-opening metathesis polymerization (ROMP)-hydrogenation was developed. Thus, hydrogenation of ROMP derived poly(octene) was accomplished under the very mild conditions of 1 atm H2 and 60°C. Strategic regeneration of a metathesis catalyst following hydrogenation allowed implementation of a "double tandem" sequence of ROMP-hydrogenation-ROMP, whereby bimodal polymer blends were generated in a one-pot process starting from a single catalyst precursor. The potential of perfluorophenoxide ligands for design of metathesis catalysts was investigated via synthesis of vinylidene complex Ru(OC 6F5)2(=C=CHBut)(dcypb) (18), where dcypb = bis(dicyclohexyl)-1,4-phosphinobutane. Protonolysis of the perfluorophenoxide ligands in 18 by HCl gave the dichloro analogue [{Ru(=C=CHBut)(dcypb)}(mu-Cl) 3]Cl (19•Cl). The structure of 19•Cl illustrates a common motif in Ru chemistry: the tendency to form trichloride-bridged dimers. By contrast, replacement of chloride ligands in 19•Cl by perfluorophenoxides yields a stable mononuclear complex (18). While both 18 and 19•Cl catalyze the ROMP of norbornene, preliminary results suggest that the mononuclear 18 is a more efficient initiator than 19•Cl. Replacement of each vinylidene in 19•Cl by a CO ligand gave [{Ru(CO)(dcypb)}(mu-Cl)3]Cl (21a), which is a direct structural analogue of 19•Cl. While 21a is stable in air, reaction with hydride reagent KBHSBu 3 gave a highly reactive trihydride K[RuH3(CO)(dcypb)] ( 28). Complex 28 was found to be moderately active for Murai catalysis and extremely active for the hydrogenation of benzophenone. A catalytic intermediate in the hydrogenation chemistry was isolated and identified as orthometallated RuH[o-C(O)(Ph)C6H4](CO)(dcypb) (30). Interestingly, the Murai activity of complex 30 is lower than that of 28, suggesting that the orthometallated species is not on the reaction path for the coupling reaction. The potentially stabilizing effect of a chelating iminopyrrolato ligand was investigated via synthesis of novel metathesis catalysts RuCl(NN ')(PCy3)(CHPh) (34) and RuCl(NN ')(py)2(CHPh) (35), where NN ' is (2, 6-iPr2-C 6H3N=CH)-2-C4H3N-. The activity of 35 for RCM was found to be very low. However, phosphine derivative 34 is an extremely robust metathesis catalyst, capable of effecting RCM in air in non-distilled, non-degassed solvent. (Abstract shortened by UMI.)
Exploiting Diffusion Prior for Out-of-Distribution Detection
Creators: name: Zhu, Armando
name: Liu, Jiabei
name: Li, Keqin
name: Dai, Shuying
name: Hong, Bo
name: Zhao, Peng
name: Wei, Changsong
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Out-of-distribution (OOD) detection is crucial for deploying robust machine learning models, especially in areas where security is critical. However, traditional OOD detection methods often fail to capture complex data distributions from large scale date. In this paper, we present a novel approach for OOD detection that leverages the generative ability of diffusion models and the powerful feature extraction capabilities of CLIP. By using these features as conditional inputs to a diffusion model, we can reconstruct the images after encoding them with CLIP. The difference between the original and reconstructed images is used as a signal for OOD identification. The practicality and scalability of our method is increased by the fact that it does not require class-specific labeled ID data, as is the case with many other methods. Extensive experiments on several benchmark datasets demonstrates the robustness and effectiveness of our method, which have significantly improved the detection accuracy.
Trade-offs, fairness, and funding for cancer drugs: key findings from a deliberative public engagement event in British Columbia, Canada
Creators: name: Bentley, Colene
name: Costa, Sarah
name: Burgess, Michael M.
name: Regier, Dean A.
name: McTaggart-Cowan, Helen
name: Peacock, Stuart J.
Publisher: name: BioMed Central
Year: 2018

description: Background: Spending on cancer drugs has risen dramatically in recent years compared to other areas of health care, due in part to higher prices associated with newly approved drugs and increased demand for these drugs. Addressing this situation requires making difficult trade-offs between cost, harms, and ability to benefit when using public resources, making it important for policy makers to have input from many people affected by the issue, including citizens. Methods: In September 2014, a deliberative public engagement event was conducted in Vancouver, British Columbia (BC), on the topic of priority setting and costly cancer drugs. The aim of the study was to gain citizens’ input on the topic and have them generate recommendations that could inform cancer drug funding decisions in BC. A market research company was engaged to recruit members of the BC general public to deliberate over two weekends (four days) on how best to allocate resources for expensive cancer treatments. Participants were stratified based on the 2006 census data for BC. Participants were asked to discuss disinvestment, intravenous versus oral chemotherapy delivery, and decision governance. All sessions were audio recorded and transcribed. Transcripts were analyzed using NVivo 11 software. Results: Twenty-four individuals participated in the event and generated 30 recommendations. Participants accepted the principle of resource scarcity and the need of governments to make difficult trade-offs when allocating health-care resources. They supported the view that cost-benefit thresholds must be set for high-cost drugs. They also expected reasonable health benefits in return for large expenditures, and supported the view that some drugs do not merit funding. Participants also wanted drug funding decisions to be made in a non-partisan and transparent way. Conclusion: The recommendations from the Vancouver deliberation can provide guidance to policy makers in BC and may be useful in challenging pricing by pharmaceutical companies.
title: Neumatosis intestinal y gas portomesenterico: causas no isquémicas.
Creators: name: Alonso Espinaco, Maria Teresa
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: Education
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Comprender los distintos mecanismos de instauración de la neumatosis intestinal y del gas portomesentérico y mostrar otras etiologías distintas a la isquemia intestinal como origen de estos signos...
The stellar mass-size relation for cluster galaxies at z = 1 with high angular resolution from the Gemini/GeMS multiconjugate adaptive optics system
Creators: name: Sweet, Sarah
name: Sharp, Robert
name: Glazebrook, Karl
name: Rigaut, Francois
name: Carrasco, Eleazar R.
name: Brodwin, Mark
name: Bayliss, Matthew
name: Stalder, Brian
name: Abraham, Roberto
name: McGregor, Peter
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We present the stellar mass–size relation for 49 galaxies within the z = 1.067 cluster SPT-CL J0546−5345, with full width at half-maximum ∼80–120 mas Ks-band data from the Gemini multiconjugate adaptive optics system (GeMS/GSAOI). This is the first such measurement in a cluster environment, performed at sub-kpc resolution at rest-frame wavelengths dominated by the light of the underlying old stellar populations. The observed stellar mass–size relation is offset from the local relation by 0.21 dex, corresponding to a size evolution proportional to (1 + z)−1.25, consistent with the literature. The slope of the stellar mass–size relation β = 0.74 ± 0.06, consistent with the local relation. The absence of slope evolution indicates that the amount of size growth is constant with stellar mass. This suggests that galaxies in massive clusters such as SPT-CL J0546−5345 grow via processes that increase the size without significant morphological interference, such as minor mergers and/or adiabatic expansion. The slope of the cluster stellar mass–size relation is significantly shallower if measured in Hubble Space Telescope (HST)/Advanced Camera for Surveys imaging at wavelengths blueward of the Balmer break, similar to rest-frame ultraviolet relations at z = 1 in the literature. The stellar mass–size relation must be measured at redder wavelengths, which are more sensitive to the old stellar population that dominates the stellar mass of the galaxies. The slope is unchanged when GeMS Ks-band imaging is degraded to the resolution of K-band HST/Near Infrared Camera and Multi-Object Spectrometer resolution but dramatically affected when degraded to Ks-band Magellan/FourStar resolution. Such measurements must be made with adaptive optics in order to accurately characterize the sizes of compact, z = 1 galaxies.
Comparative Analysis of Label-Free and 8-Plex iTRAQ Approach for Quantitative Tissue Proteomic Analysis
Creators: name: Latosinska, Agnieszka
name: Vougas, Konstantinos
name: Makridakis, Manousos
name: Klein, Julie
name: Mullen, William
name: Abbas, Mahmoud
name: Stravodimos, Konstantinos
name: Katafigiotis, Ioannis
name: Merseburger, Axel S.
name: Zoidakis, Jerome
name: Mischak, Harald
name: Vlahou, Antonia
name: Jankowski, Vera
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: High resolution proteomics approaches have been successfully utilized for the comprehensive characterization of the cell proteome. However, in the case of quantitative proteomics an open question still remains, which quantification strategy is best suited for identification of biologically relevant changes, especially in clinical specimens. In this study, a thorough comparison of a label-free approach (intensity-based) and 8-plex iTRAQ was conducted as applied to the analysis of tumor tissue samples from non-muscle invasive and muscle-invasive bladder cancer. For the latter, two acquisition strategies were tested including analysis of unfractionated and fractioned iTRAQ-labeled peptides. To reduce variability, aliquots of the same protein extract were used as starting material, whereas to obtain representative results per method further sample processing and MS analysis were conducted according to routinely applied protocols. Considering only multiple-peptide identifications, LC-MS/MS analysis resulted in the identification of 910, 1092 and 332 proteins by label-free, fractionated and unfractionated iTRAQ, respectively. The label-free strategy provided higher protein sequence coverage compared to both iTRAQ experiments. Even though pre-fraction of the iTRAQ labeled peptides allowed for a higher number of identifications, this was not accompanied by a respective increase in the number of differentially expressed changes detected. Validity of the proteomics output related to protein identification and differential expression was determined by comparison to existing data in the field (Protein Atlas and published data on the disease). All methods predicted changes which to a large extent agreed with published data, with label-free providing a higher number of significant changes than iTRAQ. Conclusively, both label-free and iTRAQ (when combined to peptide fractionation) provide high proteome coverage and apparently valid predictions in terms of differential expression, nevertheless label-free provides higher sequence coverage and ultimately detects a higher number of differentially expressed proteins. The risk for receiving false associations still exists, particularly when analyzing highly heterogeneous biological samples, raising the need for the analysis of higher sample numbers and/or application of adjustment for multiple testing.