cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DeepDiffusion: Unsupervised Learning of Retrieval-adapted Representations via Diffusion-based Ranking on Latent Feature Manifold
Creators: name: Furuya, Takahiko
name: Ohbuchi, Ryutarou
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Unsupervised learning of feature representations is a challenging yet important problem for analyzing a large collection of multimedia data that do not have semantic labels. Recently proposed neural network-based unsupervised learning approaches have succeeded in obtaining features appropriate for classification of multimedia data. However, unsupervised learning of feature representations adapted to content-based matching, comparison, or retrieval of multimedia data has not been explored well. To obtain such retrieval-adapted features, we introduce the idea of combining diffusion distance on a feature manifold with neural network-based unsupervised feature learning. This idea is realized as a novel algorithm called DeepDiffusion (DD). DD simultaneously optimizes two components, a feature embedding by a deep neural network and a distance metric that leverages diffusion on a latent feature manifold, together. DD relies on its loss function but not encoder architecture. It can thus be applied to diverse multimedia data types with their respective encoder architectures. Experimental evaluation using 3D shapes and 2D images demonstrates versatility as well as high accuracy of the DD algorithm. Code is available at https://github.com/takahikof/DeepDiffusion
description: Accepted to the IEEE Access journal
Assessment of Active Kinome Profiles in Peripheral Blood Mononuclear Cells in Renal Transplant Patient
Creators: name: Shedroff, Elizabeth
name: Ryan, WIlliam
name: Nadiminty, Nagalakshmi
name: Sindhwani, Puneet
name: Yadav, Kunal
name: Imami, Ali Sajid
name: Alganem, Khaled
name: Eby, Hunter
name: Meller, Jarek
name: Dowrkin, Lance
name: McCullumsmith, Robert
Publisher: name: Zenodo
Year: 2021
Subjects: bioinformatics
kinome
renal transplant

description: Poster presentation at the University of Toledo's Department of Medicine First Annual Research Symposium
Inestabilidad ambiental durante el Holoceno: analisis paleoecologico del sitio arqueologico Cuba, Colombia
Creators: name: Velasquez-Franco, Susana
name: González-Arango, Catalina
Publisher: name: Zenodo
Year: 2023
Subjects: paleoecologia
isotopos
carbones sedimentarios
arqueologia
Valle Medio del Rio Cauca

description: En este estudio se presenta el primer análisis multiproxy de una sección de sedimentos (175 cm) proveniente del sitio arqueológico Cuba (66PER001), que permite revisar la idea de estabilidad climática y ecológica para los bosques premontanos de la Cordillera Central de Colombia durante el Holoceno, y de esta manera enmarcar los procesos de poblamiento temprano y domesticación de plantas en el noroccidente de Suramérica. Las líneas de evidencia independientes que se analizaron para la sección Cuba, muestran cambios en las condiciones ambientales desde finales del Pleistoceno (ca. 13,3 ka AP.) al presente. En general, las concentraciones de polen y esporas en la sección Cuba muestran un efecto de degradación del componente orgánico del suelo a lo largo de la columna estratigráfica. Las tefras presentan concentraciones relativamente altas en la base de la sección, con dos aumentos de concentración importantes en 164 cm y en 95 cm respectivamente. La actividad de fuegos (carbones sedimentarios <100 y >100 µm), presentan valores altos en la base hasta los 12 cm, una marcada disminución alcanzando los valores mínimos entre 120 cm y 65 cm y un nuevo aumento en el tope entre 65 cm y 0 cm. Los valores de isótopos δ 13 C cambian desde valores muy negativos (-26,4) en la base de la sección (174 cm), hasta valores menos negativos (-22,48) en los 20 cm superiores de la sección. Los datos de la sección Cuba sugieren que la vegetación parece estar respondiendo a los cambios climáticos regionales, particularmente a los cambios de precipitación asociados con la migración de la zona de convergencia Intertropical (máximo térmico Holocénico) y el aumento de la variabilidad en fenómenos del Pacífico Oriental (ENOS).
Canadian Gallup Poll # 375
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); TV coverage of Parliament sessions(2); strikes in public services(5); personal/family financial situation(3); TV violence influences on children(2); Arab states investing in Canada(1); economic outlook(2). Note: Demographics(14).
Optimal Foraging Predicts the Ecology but Not the Evolution of Host Specialization in Bacteriophages
Creators: name: Burch, Christina L.
name: Guyader, Sébastien
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We explore the ability of optimal foraging theory to explain the observation among marine bacteriophages that host range appears to be negatively correlated with host abundance in the local marine environment. We modified Charnov's classic diet composition model to describe the ecological dynamics of the related generalist and specialist bacteriophages φX174 and G4, and confirmed that specialist phages are ecologically favored only at high host densities. Our modified model accurately predicted the ecological dynamics of phage populations in laboratory microcosms, but had only limited success predicting evolutionary dynamics. We monitored evolution of attachment rate, the phenotype that governs diet breadth, in phage populations adapting to both low and high host density microcosms. Although generalist φX174 populations evolved even broader diets at low host density, they did not show a tendency to evolve the predicted specialist foraging strategy at high host density. Similarly, specialist G4 populations were unable to evolve the predicted generalist foraging strategy at low host density. These results demonstrate that optimal foraging models developed to explain the behaviorally determined diets of predators may have only limited success predicting the genetically determined diets of bacteriophage, and that optimal foraging probably plays a smaller role than genetic constraints in the evolution of host specialization in bacteriophages.
Ovulation Order Mediates a Trade-Off between Pre-Hatching and Post-Hatching Viability in an Altricial Bird
Creators: name: Sockman, Keith W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Simultaneously dependent siblings often compete for parentally provided resources. This competition may lead to mortality, the probability of which may be a function, in part, of the individual offspring's production order. In birds, serial ovulation followed by hatching asynchrony of simultaneous dependents leads to differences in post-hatching survival that largely depend on ovulation (laying) order. This has led to the widespread assumption that early-laid eggs are of greater value and therefore should possess different maternally manipulated characteristics than later-laid eggs. However, this perspective ignores the potential effect of laying order on pre-hatching viability, an effect which some studies suggest should offset the effect of laying order on post-hatching viability. I examined the relationship between laying order and hatching and fledging probability in wild, free-living Lincoln's sparrows (Melospiza lincolnii). In broods with complete hatching success, first-laid and therefore first-hatched offspring had the highest probability of fledging, and fledging probability declined with increasing laying order. However, first-laid eggs were less likely than later-laid eggs to hatch. This effect of laying order on pre-hatching viability seemed to offset that on post-hatching viability, and, consistently, maternal investment in egg size varied little if at all with respect to laying order. These results suggest that ovulation order mediates a trade-off between pre-hatching and post-hatching viability and should encourage a re-evaluation of the solitary role post-embryonic survival often plays when researchers make assumptions about the value of propagules based on the order in which they are produced.
The Actin-Binding Protein Capulet Genetically Interacts with the Microtubule Motor Kinesin to Maintain Neuronal Dendrite Homeostasis
Creators: name: Brenman, Jay E.
name: Medina, Paul M. B.
name: Worthen, Ryan J.
name: Forsberg, Lawrence J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: BackgroundNeurons require precise cytoskeletal regulation within neurites, containing microtubule tracks for cargo transport in axons and dendrites or within synapses containing organized actin. Due to the unique architecture and specialized function of neurons, neurons are particularly susceptible to perturbation of the cytoskeleton. Numerous actin-binding proteins help maintain proper cytoskeletal regulation.Methodology/Principal FindingsFrom a Drosophila forward genetic screen, we identified a mutation in capulet-encoding a conserved actin-binding protein-that causes abnormal aggregates of actin within dendrites. Through interaction studies, we demonstrate that simultaneous genetic inactivation of capulet and kinesin heavy chain, a microtubule motor protein, produces elongate cofilin-actin rods within dendrites but not axons. These rods resemble actin-rich structures induced in both mammalian neurodegenerative and Drosophila Alzheimer's models, but have not previously been identified by loss of function mutations in vivo. We further demonstrate that mitochondria, which are transported by Kinesin, have impaired distribution along dendrites in a capulet mutant. While Capulet and Cofilin may biochemically cooperate in certain circumstances, in neuronal dendrites they genetically antagonize each other.Conclusions/SignificanceThe present study is the first molecularly defined loss of function demonstration of actin-cofilin rods in vivo. This study suggests that simultaneous, seemingly minor perturbations in neuronal dendrites can synergize producing severe abnormalities affecting actin, microtubules and mitochondria/energy availability in dendrites. Additionally, as >90% of Alzheimer's and Parkinson's cases are sporadic this study suggests mechanisms by which multiple mutations together may contribute to neurodegeneration instead of reliance on single mutations to produce disease.
Canadian Gallup Poll # 305
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); juvenile deliquency(2); personal satisfaction(8); churches and nuclear weapons(1); federal government job performance(1); US capital investment in Canada(1); government's treatment of farmers(1); Biculturalism(2). Note: Demographics(11).
Canadian Gallup Poll # 336
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); family finances(3); opposition leader job performance(1); Expo '67(1); inflation(1); Arab-Israeli conflict(1); sex education(5). Note: Demographics(11).
Theory of nonlinear excitonic response of hybrid organic perovskites in the regime of strong light-matter coupling
Creators: name: Belogur, A. D.
name: Baghdasaryan, D. A.
name: Iorsh, I. V.
name: Shelykh, I. A.
name: Shahnazaryan, V.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a quantitative study of the nonlinear optical response of layered perovskites placed inside planar photonic microcavities in the regime of strong light matter coupling, when excitonic and photonic modes hybridize and give rise to cavity polaritons. Two sources of nonlinearity are specified, the saturation of the excitonic transition with increase of the optical pump and Coulomb interaction between the excitons. It is demonstrated, that peculiar form of the interaction potential, specific to multilayer structure of organic perovskites, is responsible for substantial increase of the exciton binding energy and Rabi splitting with respect to conventional semiconductor systems. This results in dominant contribution of the Rabi splitting quench effect in the nonlinear optical response. Moreover, due to the tightly bound character of excitons, the density of Mott transition is essentially higher, allowing to reach extremely large polariton blueshifts of about 50 meV, which is order of magnitude higher than in conventional semiconductors.
Terahertz in-line digital holography of dragonfly hindwing: amplitude and phase reconstruction at enhanced resolution by extrapolation
Creators: name: Rong, Lu
name: Latychevskaia, Tatiana
name: Wang, Dayong
name: Zhou, Xun
name: Huang, Haochong
name: Li, Zeyu
name: Wang, Yunxin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report here on terahertz (THz) digital holography on a biological specimen. A continuous-wave (CW) THz in-line holographic setup was built based on a 2.52 THz CO2 pumped THz laser and a pyroelectric array detector. We introduced novel statistical method of obtaining true intensity values for the pyroelectric array detector's pixels. Absorption and phase-shifting images of a dragonfly's hind wing were reconstructed simultaneously from single in-line hologram. Furthermore, we applied phase retrieval routines to eliminate twin image and enhanced the resolution of the reconstructions by hologram extrapolation beyond the detector area. The finest observed features are 35 μm width cross veins.
description: 16 pages, 7 figures
Canadian Gallup Poll # 286
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); inflation(2); government-run businesses, banks(4); Canada buys less from US(2); China into UN(3); US capital in Canada(1); labor unions(3); taxes(3); railroad strike(3); Canada's 'New Political Party'(3); greatest problem facing Canada(2). Note: Demographics(11).
VHL Type 2B Mutations Retain VBC Complex Form and Function
Creators: name: Lee, Caroline Martz
name: Rathmell, W. Kimryn
name: Hacker, Kathryn E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Backgroundvon Hippel-Lindau disease is characterized by a spectrum of hypervascular tumors, including renal cell carcinoma, hemangioblastoma, and pheochromocytoma, which occur with VHL genotype-specific differences in penetrance. VHL loss causes a failure to regulate the hypoxia inducible factors (HIF-1α and HIF-2α), resulting in accumulation of both factors to high levels. Although HIF dysregulation is critical to VHL disease-associated renal tumorigenesis, increasing evidence points toward gradations of HIF dysregulation contributing to the degree of predisposition to renal cell carcinoma and other manifestations of the disease.Methodology/Principal FindingsThis investigation examined the ability of disease-specific VHL missense mutations to support the assembly of the VBC complex and to promote the ubiquitylation of HIF. Our interaction analysis supported previous observations that VHL Type 2B mutations disrupt the interaction between pVHL and Elongin C but maintain partial regulation of HIF. We additionally demonstrated that Type 2B mutant pVHL forms a remnant VBC complex containing the active members ROC1 and Cullin-2 which retains the ability to ubiquitylate HIF-1α.ConclusionsOur results suggest that subtypes of VHL mutations support an intermediate level of HIF regulation via a remnant VBC complex. These findings provide a mechanism for the graded HIF dysregulation and genetic predisposition for cancer development in VHL disease.
On canonical-type connections on almost contact complex Riemannian manifolds
Creators: name: Manev, Mancho
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 53C05, Secondary 53C15, 53C50

description: We consider a pair of smooth manifolds, which are the counterparts in the even-dimensional and odd-dimensional cases. They are separately an almost complex manifold with Norden metric and an almost contact manifolds with B-metric, respectively. They can be combined as the so-called almost contact complex Riemannian manifold. This paper is a survey with additions of results on differential geometry of canonical-type connections (i.e. metric connections with torsion satisfying a certain algebraic identity) on the considered manifolds.
description: 16 pages, a survey with additions
A Common and Unstable Copy Number Variant Is Associated with Differences in Glo1 Expression and Anxiety-Like Behavior
Creators: name: Wiltshire, Tim
name: Teschke, Meike
name: Distler, Margaret G.
name: Wing, Claudia
name: Wu, Chunlei
name: Palmer, Abraham A.
name: Lim, Jackie E.
name: Williams, Richard
name: Walters, Ryan
name: Sokoloff, Greta
name: Borevitz, Justin O.
name: Su, Andrew I.
name: Tarantino, Lisa M.
name: Harr, Bettina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ∼475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390–30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used it to detect this duplication in 23 of 71 inbred strains tested, and in various outbred and wild-caught mice. Presence of the duplication is associated with a cis-acting expression QTL for Glo1 (LOD>30) in BXD recombinant inbred strains. However, evidence for an eQTL for Glo1 was not obtained when we analyzed single SNPs or 3-SNP haplotypes in a panel of 27 inbred strains. We conclude that association analysis in the inbred strain panel failed to detect an eQTL because the duplication was present on multiple highly divergent haplotypes. Furthermore, we suggest that non-allelic homologous recombination has led to multiple reversions to the non-duplicated state among inbred strains. We show associations between multiple duplication-containing haplotypes, Glo1 expression and anxiety-like behavior in both inbred strain panels and outbred CD-1 mice. Our findings provide a molecular basis for differential expression of Glo1 and further implicate Glo1 in anxiety-like behavior. More broadly, these results identify problems with commonly employed tests for association in inbred strains when CNVs are present. Finally, these data provide an example of biologically significant phenotypic variability in model organisms that can be attributed to CNVs.
Canadian Gallup Poll # 313
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal elections vote intent(1); past federal elections vote(1); corporal punishment in schools(2); job satisfaction(2); Medicare Medicare(2); immigration to Canada(2); UN peacekeeping force(2); Prime Minister and opposition leader job performance(4); inflation(2). Note: Demographics(11).
AAV Recombineering with Single Strand Oligonucleotides
Creators: name: Samulski, R. Jude
name: Hirsch, Matthew L.
name: Storici, Francesca
name: Choi, Vivian W.
name: Li, Chengwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Adeno-associated virus (AAV) transduction initiates a signaling cascade that culminates in a transient DNA damage response. During this time, host DNA repair proteins convert the linear single-strand AAV genomes to double-strand circular monomers and concatemers in processes stimulated by the AAV inverted terminal repeats (ITRs). As the orientation of AAV genome concatemerization appears unbiased, the likelihood of concatemerization in a desired orientation is low (less than 1 in 6). Using a novel recombineering method, Oligo-Assisted AAV Genome Recombination (OAGR), this work demonstrates the ability to direct concatemerization specifically to a desired orientation in human cells. This was achieved by a single-strand DNA oligonucleotide (oligo) displaying homology to distinct AAV genomes capable of forming an intermolecular bridge for recombination. This DNA repair process results in concatemers with genomic junctions corresponding to the sequence of oligo homology. Furthermore, OAGR was restricted to single-strand, not duplexed, AAV genomes suggestive of replication-dependent recombination. Consistent with this process, OAGR demonstrated oligo polarity biases in all tested configurations except when a portion of the oligo targeted the ITR. This approach, in addition to being useful for the elucidation of intermolecular homologous recombination, may find eventual relevance for AAV mediated large gene therapy.
Canadian Gallup Poll # 322
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); job security(1); US prestige(1); mandatory retirement(1); French Canadians in civil service(2); political parties and issues(10); government and opposition job performances(2); Montreal Expo '67(2); mandatory retirement(1). Note: Demographics(11).
Addressing Reported Pro-Apoptotic Functions of NF-κB: Targeted Inhibition of Canonical NF-κB Enhances the Apoptotic Effects of Doxorubicin
Creators: name: Baldwin, Albert S.
name: Bednarski, Brian K.
name: Kim, Hong Jin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The ability of the transcription factor NF-κB to upregulate anti-apoptotic proteins has been linked to the chemoresistance of solid tumors to standard chemotherapy. In contrast, recent studies have proposed that, in response to doxorubicin, NF-κB can be pro-apoptotic through repression of anti-apoptotic target genes. However, there is little evidence analyzing the outcome of NF-κB inhibition on the cytotoxicity of doxorubicin in studies describing pro-apoptotic NF-κB activity. In this study, we further characterize the activation of NF-κB in response to doxorubicin and evaluate its role in chemotherapy-induced cell death in sarcoma cells where NF-κB is reported to be pro-apoptotic. Doxorubicin treatment in U2OS cells induced canonical NF-κB activity as evidenced by increased nuclear accumulation of phosphorylated p65 at serine 536 and increased DNA–binding activity. Co-treatment with a small molecule IKKβ inhibitor, Compound A, abrogated this response. RT–PCR evaluation of anti-apoptotic gene expression revealed that doxorubicin-induced transcription of cIAP2 was inhibited by Compound A, while doxorubicin-induced repression of other anti-apoptotic genes was unaffected by Compound A or siRNA to p65. Furthermore, the combination of doxorubicin and canonical NF-κB inhibition with Compound A or siRNA to p65 resulted in decreased cell viability measured by trypan blue staining and MTS assay and increased apoptosis measured by cleaved poly (ADP-ribose) polymerase and cleaved caspase 3 when compared to doxorubicin alone. Our results demonstrate that doxorubicin-induced canonical NF-κB activity associated with phosphorylated p65 is anti-apoptotic in its function and that doxorubicin-induced repression of anti-apoptotic genes occurs independent of p65. Therefore, combination therapies incorporating NF-κB inhibitors together with standard chemotherapies remains a viable method to improve the clinical outcomes in patients with advanced stage malignancies.
On nonexistence of Feller semigroups in the nontransversal case
Creators: name: Gurevich, Pavel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 47F05, 47D07

description: We give three examples of second-order elliptic operators with nonlocal boundary conditions of the Ventsel type that admit a closure in the space of continuous functions, but do not generate a Feller semigroup (i.e., a strongly continuous contractive nonnegative semigroup).
description: 3 pages
A new bound in the Littlewood--Offord problem
Creators: name: Götze, Friedrich
name: Zaitsev, Andrei Yu.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary 60F05, secondary 60E15, 60G50

description: The paper deals with studying a connection of the Littlewood--Offord problem with estimating the concentration functions of some symmetric infinitely divisible distributions.
description: 7 pages. arXiv admin note: substantial text overlap with arXiv:1411.6872
Half-metallicity in aluminum-doped zigzag silicene nanoribbons
Creators: name: Dong, Y. J.
name: Wang, X. F.
name: Vasilopoulos, P.
name: Zhai, M. X.
name: Wu, X. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The spin-dependent electronic structures of aluminum-(Al) doped zigzag silicene nanoribbons (ZSiNRs) are investigated by first-principles calculations. When ZSiNRs are substitutionally doped by a single Al atom on different sites in every three primitive cells, they become half-metallic in some cases, a property that can be used in spintronic devices. More interestingly, spin-down electrons can be transported at the Fermi energy when the Al atom is placed on the sub-edge site. In contrast, spin-up electrons can be transported at the Fermi energy when the ZSiNRs are doped on sites near their center. The magnetic moment on edge is considerably suppressed if the Al atom is doped on edge or near-edge sites. Similar results are obtained for a phosphorus-(P) and boron-(B) doped ZSiNR. When two or more Si atoms are replaced by Al atoms, in general the half-metallic behavior is replaced by a metallic, spin gapless semiconducting or semiconducting one. When a line of six Si atoms, along the ribbon's width, are replaced by Al atoms, the spin resolution of the band structure is suppressed and the system becomes nonmagnetic.
Robustness of Antiferromagnetism in the Su-Schrieffer-Heeger-Hubbard model
Creators: name: Cai, Xun
name: Li, Zi-Xiang
name: Yao, Hong
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We recently unveiled that antiferromagnetism (AFM) order can be dominantly induced by the bond Su-Schrieffer-Heeger (SSH) electron-phonon coupling (EPC), which is beyond the conventional wisdom that AFM order is usually driven by strong Coulomb interactions. Nevertheless, many aspects of the interplay between EPC and strong electronic interactions on AFM ordering remains unexplored. Here, we investigate the Su-Schrieffer-Heeger-Hubbard (SSHH) model with bond SSH phonons and onsite Hubbard interactions by large-scale quantum Monte-Carlo (QMC) simulations and obtain its ground-state phase diagram for various Hubbard interactions and EPC strength at half filling. Our results show that Hubbard interactions further enhance EPC-induced AFM, especially for small phonon frequency or in adiabatic limit, the regime most relevant to various quantum materials. This could shed further light to understanding the cooperative effect between EPC and electronic correlations in quantum materials.
description: 4 pages plus supplemental material, 5 figures
Breaking the News or Fueling the Epidemic? Temporal Association between News Media Report Volume and Opioid-Related Mortality
Creators: name: Dasgupta, Nabarun
name: Mandl, Kenneth D.
name: Brownstein, John S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundHistorical studies of news media have suggested an association between reporting and increased drug abuse. Period effects for substance use have been documented for different classes of legal and illicit substances, with the suspicion that media publicity may have played major roles in their emergence. Previous analyses have drawn primarily from qualitative evidence; the temporal relationship between media reporting volume and adverse health consequences has not been quantified nationally. We set out to explore whether we could find a quantitative relationship between media reports about prescription opioid abuse and overdose mortality associated with these drugs. We assessed whether increases in news media reports occurred before or after increases in overdose deaths.Methodology/Principal FindingsOur ecological study compared a monthly time series of unintentional poisoning deaths involving short-acting prescription opioid substances, from 1999 to 2005 using multiple cause-of-death data published by the National Center for Health Statistics, to monthly counts of English-language news articles mentioning generic and branded names of prescription opioids obtained from Google News Archives from 1999 to 2005. We estimated the association between media volume and mortality rates by time-lagged regression analyses. There were 24,272 articles and 30,916 deaths involving prescription opioids during the seven-year study period. Nationally, the number of articles mentioning prescription opioids increased dramatically starting in early 2001, following prominent coverage about the nonmedical use of OxyContin. We found a significant association between news reports and deaths, with media reporting preceding fatal opioid poisonings by two to six months and explaining 88% (p<0.0001, df 78) of the variation in mortality.Conclusions/SignificanceWhile availability, structural, and individual predispositions are key factors influencing substance use, news reporting may enhance the popularity of psychoactive substances. Albeit ecological in nature, our finding suggests the need for further evaluation of the influence of news media on health. Reporting on prescription opioids conforms to historical patterns of news reporting on other psychoactive substances.
Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif
Creators: name: Aghajanian, Amir
name: Burridge, Keith
name: Campbell, Sharon L.
name: Wittchen, Erika S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundRho family GTPases are critical regulators of the cytoskeleton and affect cell migration, cell-cell adhesion, and cell-matrix adhesion. As with all GTPases, their activity is determined by their guanine nucleotide-bound state. Understanding how Rho proteins are activated and inactivated has largely focused on regulatory proteins such as guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). However, recent in vitro studies have indicated that GTPases may also be directly regulated by redox agents. We hypothesized that this redox-based mechanism occurs in cells and affects cytoskeletal dynamics, and in this report we conclude this is indeed a novel mechanism of regulating the GTPase RhoA.Methodology/Principal FindingsIn this report, we show that RhoA can be directly activated by reactive oxygen species (ROS) in cells, and that this requires two critical cysteine residues located in a unique redox-sensitive motif within the phosphoryl binding loop. First, we show that ROS can reversibly activate RhoA and induce stress fiber formation, a well characterized readout of RhoA activity. To determine the role of cysteine residues in this mechanism of regulation, we generated cysteine to alanine RhoA mutants. Mutation of these cysteines abolishes ROS-mediated activation and stress fiber formation, indicating that these residues are critical for redox-regulation of RhoA. Importantly, these mutants maintain the ability to be activated by GEFs.Conclusions/SignificanceOur findings identify a novel mechanism for the regulation of RhoA in cells by ROS, which is independent of classical regulatory proteins. This mechanism of regulation may be particularly relevant in pathological conditions where ROS are generated and the cellular redox-balance altered, such as in asthma and ischemia-reperfusion injury.
Canadian Gallup Poll # 318
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal elections vote intent(1); past federal elections vote(1); two major parties(3); Canadian and US TV programs(2); changing Canada's parliamentary system(1); laws regulating business and labor(2); US influence on Canadian way of life(1); US in Vietnam(1) drunkenness(2); greatest problem facing Canada(1). Note: Demographics(11).
Inelastic Neutron Scattering Studies of Phonon Spectra and Simulations in Tungstates, AWO4 (A = Ba, Sr, Ca and Pb)
Creators: name: Goel, Prabhatasree
name: Gupta, M. K.
name: Mittal, R.
name: Rols, S.
name: Achary, S. N.
name: Tyagi, A. K.
name: Chaplot, S. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Lattice dynamics and high pressure phase transitions in AWO4 (A = Ba, Sr, Ca and Pb) have been investigated using inelastic neutron scattering experiments, ab-initio density functional theory calculations and extensive molecular dynamics simulations. The vibrational modes that are internal to WO4 tetrahedra occur at the highest energies consistent with the relative stability of WO4 tetrahedra. The neutron data and the ab-initio calculations are found to be in excellent agreement. The neutron and structural data are used to develop and validate an interatomic potential model. The model is used for classical molecular dynamics simulations to study their response to high pressure. We have calculated the enthalpies of the scheelite and fergusonite phases as a function of pressure, which confirms that the scheelite to fergusonite transition is second order in nature. With increase in pressure, there is a gradual change in the AO8 polyhedra, while there is no apparent change in the WO4 tetrahedra. We found that that all the four tungstates amorphize at high pressure. This is in good agreement with available experimental observations which show amorphization at around 45 GPa in BaWO4 and 40 GPa in CaWO4. On amorphization, there is an abrupt increase in the coordination of the W atom while the bisdisphenoids around A atom are considerably distorted. The pair correlation functions of the various atom pairs corroborate these observations. Our observations aid in predicting the pressure of amorphization in SrWO4 and PbWO4, which have not been experimentally reported.
description: 15 pages, 8 figures
Bilevel training schemes in imaging for total-variation-type functionals with convex integrands
Creators: name: Pagliari, Valerio
name: Papafitsoros, Kostas
name: Raiţă, Bogdan
name: Vikelis, Andreas
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: Primary: 94A08, Secondary: 49J45

description: In the context of image processing, given a $k$-th order, homogeneous and linear differential operator with constant coefficients, we study a class of variational problems whose regularizing terms depend on the operator. Precisely, the regularizers are integrals of spatially inhomogeneous integrands with convex dependence on the differential operator applied to the image function. The setting is made rigorous by means of the theory of Radon measures and of suitable function spaces modeled on $BV$. We prove the lower semicontinuity of the functionals at stake and existence of minimizers for the corresponding variational problems. Then, we embed the latter into a bilevel scheme in order to automatically compute the space-dependent regularization parameters, thus allowing for good flexibility and preservation of details in the reconstructed image. We establish existence of optima for the scheme and we finally substantiate its feasibility by numerical examples in image denoising. The cases that we treat are Huber versions of the first and second order total variation with both the Huber and the regularization parameter being spatially dependent. Notably the spatially dependent version of second order total variation produces high quality reconstructions when compared to regularizations of similar type, and the introduction of the spatially dependent Huber parameter leads to a further enhancement of the image details.
description: 27 pages, 6 figures
Dissecting Nucleosome Free Regions by a Segmental Semi-Markov Model
Creators: name: Sun, Wei
name: Xie, Wei
name: Grunstein, Michael
name: Li, Ker-Chau
name: Xu, Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundNucleosome free regions (NFRs) play important roles in diverse biological processes including gene regulation. A genome-wide quantitative portrait of each individual NFR, with their starting and ending positions, lengths, and degrees of nucleosome depletion is critical for revealing the heterogeneity of gene regulation and chromatin organization. By averaging nucleosome occupancy levels, previous studies have identified the presence of NFRs in the promoter regions across many genes. However, evaluation of the quantitative characteristics of individual NFRs requires an NFR calling method.MethodologyIn this study, we propose a statistical method to identify the patterns of NFRs from a genome-wide measurement of nucleosome occupancy. This method is based on an appropriately designed segmental semi-Markov model, which can capture each NFR pattern and output its quantitative characterizations. Our results show that the majority of the NFRs are located in intergenic regions or promoters with a length of about 400–600bp and varying degrees of nucleosome depletion. Our quantitative NFR mapping allows for an investigation of the relative impacts of transcription machinery and DNA sequence in evicting histones from NFRs. We show that while both factors have significant overall effects, their specific contributions vary across different subtypes of NFRs.ConclusionThe emphasis of our approach on the variation rather than the consensus of nucleosome free regions sets the tone for enabling the exploration of many subtler dynamic aspects of chromatin biology.
Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes
Creators: name: Shackelford, Julia
name: Pagano, Joseph S.
name: Bheda, Anjali
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Deubiquitinating enzymes (DUBs) have been increasingly implicated in regulation of cellular processes, but a functional role for Ubiquitin C-terminal Hydrolases (UCHs), which has been largely relegated to processing of small ubiquitinated peptides, remains unexplored. One member of the UCH family, UCH L1, is expressed in a number of malignancies suggesting that this DUB might be involved in oncogenic processes, and increased expression and activity of UCH L1 have been detected in EBV-immortalized cell lines. Here we present an analysis of genes regulated by UCH L1 shown by microarray profiles obtained from cells in which expression of the gene was inhibited by RNAi. Microarray data were verified with subsequent real-time PCR analysis. We found that inhibition of UCH L1 activates genes that control apoptosis, cell cycle arrest and at the same time suppresses expression of genes involved in proliferation and migration pathways. These findings are complemented by biological assays for apoptosis, cell cycle progression and migration that support the data obtained from microarray analysis, and suggest that the multi-functional molecule UCH L1 plays a role in regulating principal pathways involved in oncogenesis.
Canadian Gallup Poll # 358
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); wage/price freeze(1); Canadian films(4); labor unions(1); top political leaders approval(3); nationalizing Canadian natural resources(1); federal budget(2); cross-Canada gas pipeline(2). Note: Demographics(10).
Turkey: Supply and Demand Projections for Farm Products to 1975 with Implications for U.S. Exports
Creators: name: Moe, Lyle E.
name: Moe, Lyle E.
Publisher: name: Unknown
Year: 1967
Subjects: Agricultural and Food Policy
Crop Production/Industries
Food Consumption/Nutrition/Food Safety
International Relations/Trade
Land Economics/Use
Livestock Production/Industries
Productivity Analysis

description: Excerpts from the Introduction: This report is a summary and evaluation of a detailed report, "Agriculture in Turkey: Long-Term Projections of Supply and Demand," issued in March 1967. The detailed study was prepared by the School of Business Administration and Economics, Robert College, Istanbul, Turkey, under contract with the U.S. Department of Agriculture. The contract was administered by the Africa and Middle East Branch, Foreign Regional Analysis Division, Economic Research Service of the Department. The major objectives of the detailed report (here called the Robert College report) were the development of projections regarding the production, consumption, imports, and exports of selected Turkish agricultural products for 1970 and 1975.
Deterministic Grover search with a restricted oracle
Creators: name: Roy, Tanay
name: Jiang, Liang
name: Schuster, David I.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Grover's quantum search algorithm provides a quadratic quantum advantage over classical algorithms across a broad class of unstructured search problems. The original protocol is probabilistic, returning the desired result with significant probability on each query, but in general, requiring several iterations of the algorithm. We present a modified version to return the correct result with certainty without having user control over the quantum search oracle. Our deterministic, two-parameter "D2p" protocol utilizes generalized phase rotations replacing the phase inversions after a standard oracle query. The D2p protocol achieves a 100% success rate in no more than one additional iteration compared to the optimal number of steps in the original Grover's search enabling the same quadratic speed up. We also provide a visualization using the Bloch sphere for enhanced geometric intuition.
description: 6 pages, 4 figures
Canadian Gallup Poll # 279
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); greatest personal/family problem(1); predictions for 1960(8); event/personality of the 1950s(2); the world in 20 years(12); peace with Russia(1); marriage(2); UN job performance(2); Note: Demographics(15).
Geometric-Arithmetic Master Equation in Large and Fast Open Quantum Systems
Creators: name: Davidovic, Dragomir
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Understanding nonsecular dynamics in open quantum systems is addressed here, with emphasis on systems with large numbers of Bohr frequencies, zero temperature, and fast driving. We employ the master equation, which replaces arithmetic averages of the decay rates in the open system, with their geometric averages, and find that it can improve the second order perturbation theory, known as the Redfield equation, while enforcing complete positivity on quantum dynamics. The characteristic frequency scale that governs the approximation is the minimax frequency: the minimum of the maximum system oscillation frequency and the bath relaxation rate; this needs to be larger than the dissipation rate for it to be valid. The concepts are illustrated on the Heisenberg ferromagnetic spin-chain model. To study the accuracy of the approximation, a Hamiltonian is drawn from the Gaussian unitary ensemble, for which we calculate the fourth order time convolutionless master equation, in the Ohmic bath at zero temperature. Enforcing the geometric average, decreases the trace distance to the exact solution. Dynamical decoupling of a qubit is examined by applying the Redfield and the geometric-arithmetic master equations, in the interaction picture of the time dependent system Hamiltonian, and the results are compared to the exact path integral solution. The geometric-arithmetic approach is significantly simpler and can be super-exponentially faster compared to the Redfield approach.
DasherVR: Evaluating a Predictive Text Entry System in Immersive Virtual Reality
Creators: name: Pape, Sebastian
name: Ackermann, Jan Jakub
name: Weißker, Tim Wayan
name: Kuhlen, Torsten
Publisher: name: RWTH Aachen University
Year: 2023
Subjects: 3D User Interfaces
Accessibility
Dasher
DasherVR
Text Input
Virtual Reality

description: Towards an Inclusive and Accessible Metaverse at CHI2023 in Hamburg, Germany, CHI'23, Hamburg, Germany, 23 Apr 2023 - 23 Apr 2023; 5 Seiten (2023).
Gene Expression in Peripheral Blood Leukocytes in Monozygotic Twins Discordant for Chronic Fatigue: No Evidence of a Biomarker
Creators: name: Evengard, Birgitta
name: Sullivan, Patrick F.
name: Pedersen, Nancy L.
name: Jacks, Andreas
name: Dahlman-Wright, Karin
name: Wright, Fred A.
name: Byrnes, Andrea
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BackgroundChronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes.MethodsCases were 44 individuals who were clinically evaluated and found to meet standard international criteria for chronic fatigue syndrome or idiopathic chronic fatigue, and controls were their monozygotic co-twins who were clinically evaluated and never had even one month of impairing fatigue. Biological sampling conditions were standardized and RNA stabilizing media were used. These methodological features provide rigorous control for bias resulting from case-control mismatched ancestry and experimental error. Individual gene expression profiles were assessed using Affymetrix Human Genome U133 Plus 2.0 arrays.FindingsThere were no significant differences in gene expression for any transcript.ConclusionsContrary to our expectations, we were unable to identify a biomarker for chronic fatiguing illness in the transcriptome of peripheral blood leukocytes suggesting that positive findings in prior studies may have resulted from experimental bias.