cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The presence of identical deformed wing virus sequence variants in co-occurring Apis species in Northern Thailand may represent a potential epidemiological threat to native honey bees of Southeast Asia
Creators: name: Chantaphanwattana, Thunyarat
name: Shafiey, Hassan
name: Phokasem, Patcharin
name: Disayathanoowat, Terd
name: Paxton, Robert J.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 595

description: Widespread native honey bee species in South and East Asia (Apis cerana, Apis dorsata and Apis florea) and the imported western honey bee (Apis mellifera) share habitats and potentially also share pathogens. Chief among the threats facing A. mellifera in Europe and North America is deformed wing virus (DWV), including its two principal genotypes: A and B (DWV-A and DWV-B respectively). Though DWV-A has been recorded in Asia’s native Apis species, it is not known if DWV-B, or both DWV-A and DWV-B, are currently widespread in Asia and, if so, whether viral transmission is primarily intraspecific or interspecific. This study aims to fill these knowledge gaps by (i) determining the DWV genotype in four co-occurring Apis host species using qPCR and (ii) inferring viral transmission between them using nucleotide sequences of DWV from Apis host species collected at three independent localities in Northern Thailand. We found DWV-A and -B in all four Apis species, the exotic A. mellifera and the native A. cerana, A. dorsata and A. florea. That DWV-A sequences were identical across Apis species at the same locality, with a similar pattern for DWV-B sequences, suggests that DWV’s epidemiology is largely driven by ongoing interspecific transmission (spillover) of DWV across co-occurring native and exotic Apis species. Both genotypes of DWV represent a serious threat to Asia’s exotic and native honey bee species.
Protein kinase C (PKC) dependent induction of tissue factor (TF) by mesangial cells in response to inflammatory mediators and release during apoptosis
Creators: name: Lang, Detlef
name: Terstesse, Martin
name: Dohle, Frank
name: Bangen, Philip
name: Banas, Bernhard
name: Pauels, Hans-Gerd
name: Heidenreich, Stefan
Publisher: name: Universität Regensburg
Year: 2002
Subjects: subject: Apoptosis, tissue factor, mesangial cell, IL-1, PKC
subject: 610 Medizin

description: 1. In inflammatory kidney diseases procoagulatory activity (PCA) becomes evident. Glomerular fibrin deposits and capillary microthrombi are histopathological hallmarks in most forms of glomerulonephritis. 2. Therefore in this study the expression of tissue factor (TF) as the main inducer of thrombogenesis was examined in cultured human mesangial cells (MC) in response to proinflammatory stimuli such as interleukin-1 (IL-1 beta), tumour necrosis factor alpha (TNF-alpha) and lipopolysaccharide (LPS). Also main signalling pathways were investigated. 3. IL-1 beta, TNF-alpha and LPS induced TF in MC in a time and dose dependent manner on mRNA and protein levels. Highest activity was found after 12 h of stimulation. Induction of TF was completely blockable by BAPTA-AM, a chelator of intracellular [Ca(2+)](i) as well as calphostin, a protein kinase C (PKC) inhibitor. Activation of the protein kinase A (PKA) pathway had no influence on basal TF expression, but down-regulated cytokine-induced TF. The PKA blocker, KT5720, increased TF formation significantly. Since TF exerts its activity primarily on the surface of cells and after release of encrypted receptors we further tested TF activity in MC supernatants. IL-1 beta did not significantly increase TF activity in supernatants of intact cells. However, when MC were rendered apoptotic by oxidative metabolites, IL-1 beta treated MC released highly stimulated TF activity into the supernatants, suggesting that a paracrine activation of the coagulatory cascade can take place under such conditions. 4. Inflammatory mediators up-regulate TF expression in MC by a PKC dependent pathway whereas PKA can serve as a negative feed-back link. Apoptosis of inflammatory MC may trigger to spread PCA.
Phase transitions in the complex plane of physical parameters
Creators: name: Wei, Bo-Bo
name: Chen, Shao-Wen
name: Po, Hoi-Chun
name: Liu, Ren-Bao
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: At low temperature a thermodynamic system undergoes a phase transition when a physical parameter passes through a singularity point of the free energy, corresponding to formation of a new order. At high temperature the thermal fluctuations destroy the orders; correspondingly the free energy is a smooth function of the physical parameter and the singularity would occur only at complex values of the parameter. Since a complex parameter is unphysical, at high temperature no phase transition is expected with varying the physical parameter. Here we show that the quantum evolution, driven by a designed interaction, of a system initialized in thermal equilibrium is equivalent to the partition function of a complex parameter. Therefore we can access the complex singularity points of thermodynamic functions and observe phase transitions even at high temperatures. This discovery makes it possible to study thermodynamics in the complex plane of physical parameters.
description: 27 Pages, 6 figures (with supplementary information 7 Pages)
Control of magnetization reversal in oriented Strontium Ferrite thin films
Creators: name: Roy, Debangsu
name: Kumar, P S Anil
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Oriented Strontium Ferrite films with the c axis orientation were deposited with varying oxygen partial pressure on Al2O3(0001) substrate using PLD technique. The angle dependent magnetic hysteresis, remanent coercivity and temperature dependent coercivity had been employed to understand the magnetization reversal of these films. It was found that the Strontium Ferrite thin film grown at lower (higher) oxygen partial pressure shows Stoner-Wohlfarth type (Kondorsky like) reversal. The relative importance of pinning and nucleation processes during magnetization reversal is used to explain the type of the magnetization reversal with different oxygen partial pressure during growth.
Subwavelength imaging of sparse broadband sources surrounded by an open disordered medium from a single antenna
Creators: name: Li, Lianlin
name: Li, Fang
name: Cui, Tie Jun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In this letter we study the subwavelength imaging of sparse broadband sources inside a disordered medium by processing the data acquired by a single antenna. A mathematical model has been developed for solving such problem based on the idea of sparse reconstruction. We show that the strongly disordered medium can serves as an efficient apparatus for compressive measurement, which shifts the complexity of devising compressive sensing (CS) hardware from the design, fabrication and electronic control. The proposed method and associated results can find applications in several imaging disciplines, such as optics, THz, RF or ultrasound imaging.
Regulation of glucose transporters in human peritoneal mesothelial cells
Creators: name: Fischereder, Michael
name: Schröppel, Bernd
name: Wiese, Patrick
name: Fink, Monika
name: Banas, Bernhard
name: Schmidbauer, Stefan
name: Schlöndorff, Detlef
Publisher: name: Universität Regensburg
Year: 2003
Subjects: subject: Peritoneal dialysis; Biocompatibility; Inflammation; Glucose transporter
subject: 610 Medizin

description: BACKGROUND: Risk factors for peritoneal fibrosis and mesothelial cell (MsC) injury in CAPD are infections and bioincompatibility of the dialysate, including high glucose concentrations. To study a potential link between dialysate and glucose toxicity in MsC, we investigated the expression of facilitative glucose transporters (GLUT), which could contribute to glucose toxicity. METHODS: After induction of cell differentiation, MsC were incubated in regular medium or medium with 60 mM D-glucose, 30 mM glucose plus 30 mM mannitol, 60 mM mannitol, PD effluent, or with a cytokine mix. Expression of GLUT1, GLUT3, SGLT and GAPDH/L32 was studied by RNase protection assay. MsC were incubated under identical conditions with 14C-fluoro-deoxy-glucose for 30 minutes and glucose uptake was measured. To estimate Vmax and Km, 14C-fluoro-deoxy-glucose uptake rates were determined over a range of 0.6 to 10 mM unlabeled glucose. RESULTS: The cytokine mix significantly stimulated GLUT1 expression (3-fold) and GLUT3 (1.7-fold). There was a 1.4-fold increase in GLUT1 (p<0.05) and a 1.7-fold increase in GLUT3 (p<0.05) after incubation in high glucose but not in mannitol or PD-effluent controls. Glucose uptake studies confirmed this increase after incubation in 30 mM (p<0.05) and 60 mM glucose solutions. Kinetic studies showed the Km was approximately 3.7 mM for this transport. CONCLUSIONS: GLUT mRNA expression and glucose uptake are induced by high ambient glucose concentrations and cytokines. Unlike many other cells, MsC are not able to protect themselves from increased glucose concentrations by downregulation of GLUTs. The intracellular glucose concentration may therefore increase during CAPD, affecting growth factor expression and glycosylation, and contributing to glucose toxicity.
Gebhard Spahr, Oberschwäbische Barockstraße, Bd. 5
Creators: name: Pellens, Karl
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
Simulation of pumping mechanism of H2O-masers in circumstellar envelopes of late-type stars
Creators: name: Nesterenok, Aleksandr
Publisher: name: arXiv
Year: 2013
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The radiative transfer problem is considered in dense gas-dust clouds. Physical parameters are adopted in simulations corresponding to gas-dust clouds in the circumstellar envelopes of late-type stars. An one-dimensional plane-parallel slab geometry of the cloud is considered. The radiative transfer problem is solved using the accelerated lambda iteration technique. The rotational levels of the five lowest vibrational levels of H2O-molecule are considered in the simulations. The level populations of H2O-molecule are computed as a function of distance in the cloud. The conditions of the level population inversion occurrence are investigated. In particular, the factors controlling the population inversion in the 22.2 GHz maser line are considered. A radiative excitation of the molecules by external radiation field of a star is considered together with the collisional pumping of the maser.
Ute-Nortrud Kaiser, Jerg Rathgeb - Spurensicherung
Creators: name: Hummel, Heribert
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
Direct Measurement of Surface Transport on a Bulk Topological Insulator
Creators: name: Barreto, Lucas
name: Kühnemund, Lisa
name: Edler, Frederik
name: Tegenkamp, Christoph
name: Mi, Jianli
name: Bremholm, Martin
name: Iversen, Bo Brummerstedt
name: Frydendahl, Christian
name: Bianchi, Marco
name: Hofmann, Philip
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Topological insulators are guaranteed to support metallic surface states on an insulating bulk, and one should thus expect that the electronic transport in these materials is dominated by the surfaces states. Alas, due to the high remaining bulk conductivity, surface contributions to transport have so-far only been singled out indirectly via quantum oscillations, or for devices based on gated and doped topological insulator thin films, a situation in which the surface carrier mobility could be limited by defect and interface scattering. Here we present the first direct measurement of surface-dominated conduction on an atomically clean surface of bulk-insulating Bi$_2$Te$_2$Se. Using nano-scale four point setups with variable contact distance, we show that the transport at 30 K is two-dimensional rather than three-dimensional and by combining these measurements with angle-resolved photoemission results from the same crystals, we find a surface state mobility of 390(30) cm$^{2}$V$^{-1}$s$^{-1}$ at 30 K at a carrier concentration of 8.71(7)$\times 10^{12}$ cm$^{-2}$.
Veit Stoß. Bildhauer von Horb, hrsg. von Franz Geßler
Creators: name: Hummel, Heribert
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
Bispectrum of cosmological density perturbations in the most general second-order scalar-tensor theory
Creators: name: Takushima, Yuichiro
name: Terukina, Ayumu
name: Yamamoto, Kazuhiro
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the bispectrum of the matter density perturbations induced by the large scale structure formation in the most general second-order scalar-tensor theory that may possess the Vainshtein mechanism as a screening mechanism. On the basis of the standard perturbation theory, we derive the bispectrum being expressed by a kernel of the second order of the density perturbations. We find that the kernel at the leading order is characterized by one parameter, which is determined by the solutions of the linear density perturbations, the Hubble parameter and the other function specifying nonlinear interactions. This does not allow for varied behavior in the bispectrum of the matter density perturbations in the most general second-order scalar-tensor theory equipped with the Vainshtein mechanism. We exemplify the typical behavior of the bispectrum in a kinetic gravity braiding model.
description: 17 pages, 3 figures
Wolfgang Irtenkauf Stuttgarter Zimelien
Creators: name: Hummel, Heribert
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
A standard protocol to report discrete stage-structured demographic information
Creators: name: Gascoigne, Samuel J. L.
name: Compagnoni, Aldo
name: Knight, Tiffany M.
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: Stage-based demographic methods, such as matrix population models (MPMs), are powerful tools used to address a broad range of fundamental questions in ecology, evolutionary biology and conservation science. Accordingly, MPMs now exist for over 3000 species worldwide. These data are being digitised as an ongoing process and periodically released into two large open-access online repositories: the COMPADRE Plant Matrix Database and the COMADRE Animal Matrix Database. During the last decade, data archiving and curation of COMPADRE and COMADRE, and subsequent comparative research, have revealed pronounced variation in how MPMs are parameterized and reported. Here, we summarise current issues related to the parameterisation and reporting of MPMs that arise most frequently and outline how they affect MPM construction, analysis, and interpretation. To quantify variation in how MPMs are reported, we present results from a survey identifying key aspects of MPMs that are frequently unreported in manuscripts. We then screen COMPADRE and COMADRE to quantify how often key pieces of information are omitted from manuscripts using MPMs. Over 80% of surveyed researchers (n = 60) state a clear benefit to adopting more standardised methodologies for reporting MPMs. Furthermore, over 85% of the 300 MPMs assessed from COMPADRE and COMADRE omitted one or more elements that are key to their accurate interpretation. Based on these insights, we identify fundamental issues that can arise from MPM construction and communication and provide suggestions to improve clarity, reproducibility and future research utilising MPMs and their required metadata. To fortify reproducibility and empower researchers to take full advantage of their demographic data, we introduce a standardised protocol to present MPMs in publications. This standard is linked to www.compadre-db.org, so that authors wishing to archive their MPMs can do so prior to submission of publications, following examples from other open-access repositories such as DRYAD, Figshare and Zenodo. Combining and standardising MPMs parameterized from populations around the globe and across the tree of life opens up powerful research opportunities in evolutionary biology, ecology and conservation research. However, this potential can only be fully realised by adopting standardised methods to ensure reproducibility.
Deliverable 5.5: Report on SbD strategies
Creators: name: Larraz, Alberto
name: BARBERO COLMENAR, ELENA
name: Ballesteros Riaza, Arantxa
name: Vela, Verónica
Publisher: name: Zenodo
Year: 2023
Subjects: Safe by Design
MCNM
HARN
Risk Management
surface engineering
nanomaterials

description: Deliverable 5.5 aims to collect the work conducted within task 5.3 "Safe by design strategies development", in particular subtask 5.3.1 (safe by material design strategies) and subtask 5.3.2 (safe by process design strategies). For subtask 5.3.1, we did an extensive literature review in order to come out with a library of well-balanced safe by material design strategies applied to different types of nanomaterials. Based on these general strategies, specific strategies that could be applied to the materials developed in DIAGONAL project have been proposed with the aim of being implemented later under the framework of task 5.4 "Safe by design strategies demonstration." Similarly, the work conducted under subtask 5.3.2 "Safe by process design strategies" focused on the exhaustive analysis of the production processes as well as the results obtained from the monitoring campaigns. According to this analysis, the proper safe by process design strategies have been proposed also considering, where applicable, the recommendation for implementing risk management measures (RMM) identified also in WP6. These strategies would be used as well as an input for the activities covered by Task 5.4, related to the demonstration of the SbD strategies within DIAGONAL case studies, as well as a base for the work that is being conducted in Task 5.5 "SbD best practices guidelines".
It is worth to mention that the activities conducted in this task and the results reported in the current deliverable, are related to the work done before, specifically to the results reported in deliverable D5.1 "DIAGONAL SbD and SusbD implementation framework" in the third mont of the project which was aimed at implementing a theoretical framework for the subsequent development of Safe-by-Design (SbD) and Sustainability-by-Design (SusbD) strategies under the scope of High Aspect Ratio Nanoparticle (HARN) and Multi-Component Nanomateria (MCNM) production.
Building Information Twinning: Investigating the Software Architecture of a Building’s Digital Twin
Creators: name: Williams, Brad
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 120104 Architectural Science and Technology (incl. Acoustics, Lighting, Structure and Ecologically Sustainable Design)
subject: FOS: Civil engineering

description: This thesis critically examines the adaptation of Building Information Modeling (BIM) to receive real-time sensor data, bringing it closer to a representational paradigm known as ’Digital Twin’ (DT) in the Architecture, Engineering, and Construction (AEC) industry. However, current monolithic BIM systems struggle with this integration, as demonstrated by the development of a construction LiDAR to BIM translation service. To address these challenges, the research proposes a microservices-based architecture with Docker containers, enabling efficient communication, adaptable data handling, and enhanced scalability. This thesis contrasts this novel approach against traditional methods, revealing its improved handling in dependency management and scalability. It concludes by advocating for a distributed, task-oriented BIM system that aligns with the increasingly collaborative AEC industry and modern software development practices.
Projective differential geometry of multidimensional dispersionless integrable hierarchies
Creators: name: Bogdanov, L. V.
name: Konopelchenko, B. G.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We introduce a general setting for multidimensional dispersionless integrable hierarchy in terms of differential $m$-form $Ω_m$ with the coefficients satisfying the Plücker relations, which is gauge-invariantly closed and its gauge-invariant coordinates (ratios of coefficients) are (locally) holomorphic with respect to one of the variables (the spectral variable). We demonstrate that this form defines a hierarchy of dispersionless integrable equations in terms of commuting vector fields locally holomorphic in the spectral variable. The equations of the hierarchy are given by the gauge-invariant closedness equations.
description: 10 pages, the text of the talk at PMNP2013 (Gallipoli, Italy, 22-29 June 2013)
Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis
Creators: name: Banas, Bernhard
name: Wörnle, Markus
name: Berger, Thorsten
name: Nelson, Peter J.
name: Cohen, Clemens D.
name: Kretzler, Matthias
name: Pfirstinger, Jochen
name: Mack, Matthias
name: Lipp, Martin
name: Gröne, Hermann-Josef
name: Schlöndorff, Detlef
Publisher: name: Universität Regensburg
Year: 2002
Subjects: subject: 610 Medizin

description: The release of chemokines by intrinsic renal cells is an important mechanism for the regulation of leukocyte trafficking during renal inflammation. The expression of chemokine receptors by intrinsic renal cells such as mesangial cells (MC) suggests an expanded role for chemokine-chemokine receptor biology in local immunomodulation and potentially glomerular homeostasis. By immunohistochemistry we found the chemokine receptor CCR7 expressed in a mesangial pattern while the CCR7 ligand SLC/CCL21 showed a podocyte-specific expression. CCR7 expression was further characterized by RT-PCR, RNase protection assays, and FACS analysis of cultured human MC, and was found to be constitutively present. Real-time PCR of microdissected glomeruli confirmed the expression of SLC/CCL21. A functional role for CCR7 was demonstrated for human MC migration and proliferation. A protective effect of SLC/CCL21 was shown for MC survival in Fas Ab-induced apoptosis. Finally, "wound healing" was enhanced in the presence of SLC/CCL21 in an in vitro injury model. The constitutive glomerular expression of CCR7 and its ligand SLC/CCL21 in adjacent cell types of the human kidney suggests novel biological functions of this chemokine/chemokine receptor pair and a potential role in processes involved in glomerular homeostasis and regeneration.
Sterile neutrino dark matter bounds from galaxies of the Local Group
Creators: name: Horiuchi, Shunsaku
name: Humphrey, Philip J.
name: Onorbe, Jose
name: Abazajian, Kevork N.
name: Kaplinghat, Manoj
name: Garrison-Kimmel, Shea
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that the canonical oscillation-based (non-resonant) production of sterile neutrino dark matter is inconsistent at $>99$% confidence with observations of galaxies in the Local Group. We set lower limits on the non-resonant sterile neutrino mass of $2.5$ keV (equivalent to $0.7$ keV thermal mass) using phase-space densities derived for dwarf satellite galaxies of the Milky Way, as well as limits of $8.8$ keV (equivalent to $1.8$ keV thermal mass) based on subhalo counts of $N$-body simulations of M 31 analogues. Combined with improved upper mass limits derived from significantly deeper X-ray data of M 31 with full consideration for background variations, we show that there remains little room for non-resonant production if sterile neutrinos are to explain $100$% of the dark matter abundance. Resonant and non-oscillation sterile neutrino production remain viable mechanisms for generating sufficient dark matter sterile neutrinos.
description: 10 pages, 4 figures, 2 tables. Submitted to PRD
Max Gögler/Gregor Richter (Hrsg.), Das Land Württemberg-Hohenzollern 1945-1952
Creators: name: Köhler, Joachim
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
MATCASC: A tool to analyse cascading line outages in power grids
Creators: name: Koç, Yakup
name: Verma, Trivik
name: Araujo, Nuno A. M.
name: Warnier, Martijn
Publisher: name: arXiv
Year: 2013
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Blackouts in power grids typically result from cascading failures. The key importance of the electric power grid to society encourages further research into sustaining power system reliability and developing new methods to manage the risks of cascading blackouts. Adequate software tools are required to better analyze, understand, and assess the consequences of the cascading failures. This paper presents MATCASC, an open source MATLAB based tool to analyse cascading failures in power grids. Cascading effects due to line overload outages are considered. The applicability of the MATCASC tool is demonstrated by assessing the robustness of IEEE test systems and real-world power grids with respect to cascading failures.
Modulation of HIV-1 enhancer activity and virus production by cAMP
Creators: name: Banas, B.
name: Eberle, J.
name: Banas, B.
name: Schlöndorff, D.
name: Luckow, B.
Publisher: name: Universität Regensburg
Year: 2001
Subjects: subject: HIV-1 enhancer; cAMP; Negative regulation; Transient transfection; Virus production
subject: 610 Medizin

description: The effect of cAMP on the transcriptional activity of the HIV-1 long terminal repeat/enhancer was investigated and compared to the effect of cAMP on virus replication. In culture cAMP repressed virus replication in vivo using different cell types. Transient transfection studies with HIV-1 enhancer-derived luciferase reporter gene constructs identified the minimal DNA sequence mediating the negative regulatory effect of cAMP on HIV-1 transcription. A single nuclear factor kappaB element from the HIV-1 enhancer mediates the repressive effect on transcription. AP-2 is not involved in cAMP repression. Stable transfection of Jurkat T cells with the co-activators CREB binding protein (CBP) and p300 completely abolished the cAMP repressive effect, supporting the hypothesis that elevation of intracellular cAMP increases phosphorylation of CREB, which then competes with phosphorylated p65 and Ets-1 for limiting amounts of CBP/p300 thereby mediating the observed repressive effect on transcription. These findings suggest an important role of cAMP on HIV-1 transcription.
Computational-aided engineering of a selective unspecific peroxygenase toward enantiodivergent β-ionone hydroxylation
Creators: name: Münch, Judith
name: Soler, Jordi
name: Hunecke, Nicole
name: Homann, Dominik
name: Garcia-Borrás, Marc
name: Weissenborn, Martin J.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Unspecific peroxygenases (UPOs) perform oxyfunctionalizations for a wide range of substrates utilizing H2O2 without the need for further reductive equivalents or electron transfer chains. Tailoring these promising enzymes toward industrial application was intensely pursued in the last decade with engineering campaigns addressing the heterologous expression, activity, stability, and improvements in chemo- and regioselectivity. One hitherto missing integral part was the targeted engineering of enantioselectivity for specific substrates with poor starting enantioselectivity. In this work, we present the engineering of the short-type MthUPO toward the enantiodivergent hydroxylation of the terpene model substrate, β-ionone. Guided by computational modeling, we designed a small smart library and screened it with a GC–MS setup. After two rounds of iterative protein evolution, the activity increased up to 17-fold and reached a regioselectivity of up to 99.6% for the 4-hydroxy-β-ionone. Enantiodivergent variants were identified with enantiomeric ratios of 96.6:3.4 (R) and 0.3:99.7 (S), respectively.
Expression of chemokines and their receptors in nephrotoxic serum nephritis
Creators: name: Schadde, E.
name: Kretzler, M.
name: Banas, B.
name: Luckow, B.
name: Assmann, K.
name: Schlöndorff, D.
Publisher: name: Universität Regensburg
Year: 2000
Subjects: subject: CC-chemokines; chemokine receptors; glomerulonephritis; mouse; nephrotoxic glomerulonephritits
subject: 610 Medizin

description: BACKGROUND: Chemokines play a major role in leukocyte infiltration in inflammatory kidney diseases. The specificity of the chemokine action is determined by the restricted expression of the corresponding receptors on leukocytes. We therefore simultaneously studied the expression of CC-chemokine and CC-chemokine receptor 1-5 (CCR 1-5) mRNA in an accelerated model of nephrotoxic nephritis in CD-1 mice. METHODS: Kidneys were harvested at day 0, 2 and 7. Induction of nephritis was confirmed by assessment of albuminuria by ELISA and by histological evaluation. RNA was prepared from cortex and isolated glomeruli. RNase protection assays were performed to study the expression of chemokines, RNase protection assays as well as quantitative RT-PCR assays to study the expression of chemokine receptors. RESULTS: In the cortex of nephritic kidneys mRNA for MCP-1 was increased 5-fold on day 2 and increased 4-fold on day 7 as compared to controls. mRNA for RANTES was increased 5-fold on day 7 and mRNA for IP-10 6-fold on day 7. The increase of mRNA for the chemokine receptors CCR1 and 5 was between 2-fold and 3-fold determined by RNase protection assay and for CCR1, 2 and 5 between 2- and 4-fold as determined by RT-PCR. In isolated glomeruli we found by RT-PCR an increase of CCR1, CCR2 and CCR5 of between 3 and 12-fold. CONCLUSION: These results show that chemokines and their specific chemokine receptors are increased in parallel in this model of glomerulonephritis, consistent with the potential role of the chemokine system in leukocyte recruitment to the immune injured kidney.
Hubble Space Telescope/Advanced Camera for Surveys Confirmation of the Dark Substructure in A520
Creators: name: Jee, M. James
name: Hoekstra, Henk
name: Mahdavi, Andisheh
name: Babul, Arif
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the results from a weak gravitational lensing study of the merging cluster A520 based on the analysis of Hubble Space Telescope/Advanced Camera for Surveys (ACS) data. The excellent data quality allows us to reach a mean number density of source galaxies of ~109 per sq. arcmin, which improves both resolution and significance of the mass reconstruction compared to a previous study based on Wide Field Planetary Camera 2 (WFPC2) images. We take care in removing instrumental effects such as the trailing of charge due to radiation damage of the ACS detector and the position-dependent point spread function (PSF). This new ACS analysis confirms the previous claims that a substantial amount of dark mass is present between two luminous subclusters. We examine the distribution of cluster galaxies and observe very little light at this location. We find that the centroid of the dark peak in the current ACS analysis is offset to the southwest by ~1 arcmin with respect to the centroid from the WFPC2 analysis. Interestingly, this new centroid is in better spatial agreement with the location where the X-ray emission is strongest, and the mass-to-light ratio estimated with this centroid is much higher 813+-78 M_sun/L_Rsun than the previous value; the aperture mass based on the WFPC2 centroid provides a slightly lower, but consistent mass. Although we cannot provide a definite explanation for the presence of the dark peak, we discuss a revised scenario, wherein dark matter with a more conventional range sigma_DM/m_DM < 1 cm^2/g of self-interacting cross-section can lead to the detection of this dark substructure. If supported by detailed numerical simulations, this hypothesis opens up the possibility that the A520 system can be used to establish a lower limit of the self-interacting cross-section of dark matter.
description: Accepted to The Astrophysical Journal
Hans Wicki, Das Königreich Württemberg im Ersten Weltkrieg
Creators: name: Ziegler, Uwe
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
Franz Quarthai (Hrsg.), Zwischen Schwarzwald und Schwäbischer Alb
Creators: name: Binder, Hans-Otto
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
Gaps in the space of skeletal signatures
Creators: name: Anderson, James W
name: Wootton, Aaron
Publisher: name: arXiv
Year: 2013
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 14H37, 30F20

description: Skeletal signatures were introduced in [J W Anderson and A Wootton, A Lower Bound for the Number of Group Actions on a Compact Riemann Surface, Algebr. Geom. Topol. 12 (2012) 19--35.] as a tool to describe the space of all signatures with which a group can act on a surface of genus $σ\geq 2$. In the present paper we provide a complete description of the gaps that appear in the space of skeletal signatures, together with proofs of the conjectures posed in our earlier work.
description: 10 pages, 1 figure
Executive functions and borderline personality features in adolescents with major depressive disorder
Creators: name: Albermann, Mona
name: Emery, Sophie
name: Baumgartner, Noemi
name: Strumberger, Michael
name: Erb, Suzanne
name: Wöckel, Lars
name: Müller-Knapp, Ulrich
name: Rhiner, Bruno
name: Contin-Waldvogel, Brigitte
name: Bachmann, Silke
name: Schmeck, Klaus
name: Berger, Gregor
name: Häberling, Isabelle
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 150

description: Background: Executive functions (EF) consolidate during adolescence and are impaired in various emerging psychiatric disorders, such as pediatric Major Depressive Disorder (pMDD) and Borderline Personality Disorder. Previous studies point to a marked heterogeneity of deficits in EF in pMDD. We examined the hypothesis that deficits in EF in adolescents with pMDD might be related to comorbid Borderline Personality features (BPF). Methods: We examined a sample of 144 adolescents (15.86 ± 1.32) diagnosed with pMDD. Parents rated their child’s EF in everyday life with the Behavior Rating Inventory of Executive Function (BRIEF) and BPF with the Impulsivity and Emotion Dysregulation Scale (IED-27). The adolescents completed equivalent self-rating measures. Self- and parent-ratings of the BRIEF scores were compared with paired t-Tests. Correlation and parallel mediation analyses, ICC, and multiple regression analyses were used to assess symptom overlap, parent-child agreement, and the influence of depression severity. Results: Over the whole sample, none of the self- or parent-rated BRIEF scales reached a mean score above T > 65, which would indicate clinically impaired functioning. Adolescents tended to report higher impairment in EF than their parents. Depression severity was the strongest predictor for BPF scores, with Emotional Control predicting parent-rated BPF and Inhibit predicting self-rated BPF. Furthermore, the Behavioral Regulation Index, which includes EF closely related to behavioral control, significantly mediated the relationship between depression severity and IED-27 factors emotional dysregulation and relationship difficulties but not non-suicidal self-injuries. Conclusion: On average, adolescents with depression show only subtle deficits in executive functioning. However, increased EF deficits are associated with the occurrence of comorbid borderline personality features, contributing to a more severe overall psychopathology. Therefore, training of executive functioning might have a positive effect on psychosocial functioning in severely depressed adolescents, as it might also improve comorbid BPF.
Towards Contextualized Synthetic Dataset for Construction Site
Creators: name: Liu, Haoyu
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 120199 Architecture not elsewhere classified
subject: FOS: Civil engineering

description: Datasets are the cornerstone of AI[29], the absence of which has contributed to the slow adoption of AI technologies in the construction industry[10]. The hazardous nature of the construction site, the costly and labor-intensive labeling process, and other challenges make collecting construction datasets difcult. In order to overcome this issue, this research explores an approach to synthetic data generation and presents and validates its benefts compared to real datasets. To specify the scope, the problem of brick recycling from construction waste on-site is chosen for this study as it well represents the construction context’s messy nature. This research utilizes Unity Perception to build the scene of synthetic data generation to simulate the construction context. A series of experiments are proposed with diferent levels of realism, generating thousands of images for the brick recycling scenario at a considerably lesser cost than the real dataset. In an attempt to validate the benefts of the synthetic dataset in terms of performance, real datasets are collected, and object detection models are trained on real data, synthetic data, or real data combined with synthetic data. A benchmarking test is performed and validates that synthetic data mixed with real data could improve the performance of the model in the construction context. However, it still needs improvements if the synthetic data is to replace real data fully.
Whole-genome sequence of Aneurinibacillus sp. Ricciae_BoGa-3, isolated from Riccia fluitans
Creators: name: Hildebrandt, Marvin
name: Bleile, Isabell E.
name: Althoff, Felix
name: Zachgo, Sabine
name: Bräutigam, Andrea
name: Verwaaijena, Bart
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 576

description: Here, we present the Nanopore-only genome sequence of Aneurinibacillus sp. Ricciae_BoGa-3. It was isolated from Riccia fluitans ecotype BoGa-3 and its source was Botanical Garden Osnabrück (Germany). The complete circular genome is 4,981,254 bp with a GC content of 44.8%.
Re-Presentation: Narrative Medicine Workshop Rundown
Creators: name: Northwest Narrative Medicine Collaborative
Publisher: name: Oregon Health and Science University Library
Year: 2023
Subjects: subject: Narrative Medicine
subject: curriculum

description: This curriculum is included in the digital library as part of a partnership between the OHSU Library and the Northwest Narrative Medicine Collaborative to share Narrative Medicine curriculum and the items used in those teaching sessions. For additional information about how the work is used in teaching and a community driven context, please visit Accessible Narrative Medicine website. The website can serve as a starting point for discussion, introspection, and writing. This guide is timed for a 1-hour, 45-minute virtual workshop with 8-10 participants and includes a short break. Adjust your time estimates for groups that are larger, smaller, or of different lengths. If your workshop is in person, adjust timing and exercises as necessary. Find facilitator tips, production notes, and sample language throughout to help make your workshop successful.
Chemokine and chemokine receptor expression in a novel human mesangial cell line
Creators: name: Banas, B.
name: Luckow, B.
name: Möller, M.
name: Klier, C.
name: Nelson, P. J.
name: Schadde, E.
name: Brigl, M.
name: Halevy, D.
name: Holthöfer, H.
name: Reinhart, B.
name: Schlöndorff, D.
Publisher: name: Universität Regensburg
Year: 1999
Subjects: subject: 610 Medizin

description: Chemokines are thought to play a pivotal role in mediating the selective migration of leukocytes into sites of tissue injury. The local production of chemokines by mesangial cells (MC) has been linked to inflammatory processes within the glomerulus. To study the chemokine biology of human MC, an immortalized human MC line was generated and then chemokine and chemokine receptor expression was examined in response to various proinflammatory stimuli. The results show that human MC have a specific and limited repertoire of chemokine expression. The stimulus-specific regulation of the chemokines monocyte chemoattractant protein- (MCP- 1), regulated upon activation, normal T cell expressed and secreted (RANTES), interleukin-8 (IL-8), and IP-10 was demonstrated using RNase protection assays. Transcripts for the chemokines MIP-1alpha, MIP-1beta, I-309, or lymphotactin could not be detected. The expression of CC chemokine receptors was investigated by reverse transcription-PCR and RNase protection assays. MC stimulated with interferon-gamma (IFN-gamma) expressed mRNA for the chemokine receptor CCR1. The expression could be further increased by activating the cells with a combination of tumor necrosis factor-a (TNF-alpha), IL-1beta, and IFN-gamma. Under these conditions, no mRNA for CCR2, CCR3, CCR4, CCR5, or CCR8 was detected. A comparison of the immortalized human mesangial cells with primary cells showed identical expression patterns of chemokine receptors. To demonstrate functional activity of chemokine receptors expressed by human MC, chemotaxis assays were performed. MC stimulated with a combination of TNF-alpha, IL-1beta, and IFN-gamma, but not unstimulated MC, migrated toward a RANTES gradient. Eotaxin did not enhance the migratory activity of human MC. In summary, a novel human mesangial cell line was established and the pattern of chemokine expression was examined. For the first time, the inducible expression of functionally active CCR1 by human MC was shown.
Witness: Narrative Medicine Workshop Guide
Creators: name: Northwest Narrative Medicine Collaborative
Publisher: name: Oregon Health and Science University Library
Year: 2023
Subjects: subject: Narrative Medicine
subject: curriculum

description: This curriculum is included in the digital library as part of a partnership between the OHSU Library and the Northwest Narrative Medicine Collaborative to share Narrative Medicine curriculum and the items used in those teaching sessions. For additional information about how the work is used in teaching and a community driven context, please visit Accessible Narrative Medicine website. The website can serve as a starting point for discussion, introspection, and writing. This guide is timed for a 1-hour, 45-minute virtual workshop with 8-10 participants and includes a short break. Adjust your time estimates for groups that are larger, smaller, or of different lengths. If your workshop is in person, adjust timing and exercises as necessary. Find facilitator tips, production notes, and sample language throughout to help make your workshop successful.
Optimal and sub-optimal quadratic forms for non-centered Gaussian processes
Creators: name: Grebenkov, D. S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Individual random trajectories of stochastic processes are often analyzed by using quadratic forms such as time averaged (TA) mean square displacement (MSD) or velocity auto-correlation function (VACF). The appropriate quadratic form is expected to have a narrow probability distribution in order to reduce statistical uncertainty of a single measurement. We consider the problem of finding the optimal quadratic form that minimizes a chosen cumulant moment (e.g., the variance) of the probability distribution, under the constraint of fixed mean value. For discrete non-centered Gaussian processes, we construct the optimal quadratic form by using the spectral representation of the cumulant moments. Moreover, we obtain a simple explicit formula for the smallest achievable cumulant moment that may serve as a quality benchmark for other quadratic forms. We illustrate the optimality issues by comparing the optimal variance with the variances of the TA MSD and TA VACF of fractional Brownian motion superimposed with a constant drift and independent Gaussian noise.
Ulrich Pfister, Die Anfänge von Geburtenbeschränkung
Creators: name: Bátori, Ingrid
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 5 (1986): Rottenburger Jahrbuch für Kirchengeschichte, Band 5
Temporal evolution and scaling of mixing in two-dimensional Rayleigh-Taylor turbulence
Creators: name: Zhou, Quan
Publisher: name: arXiv
Year: 2013
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We report a high-resolution numerical study of two-dimensional (2D) miscible Rayleigh-Taylor (RT) incompressible turbulence with the Boussinesq approximation. An ensemble of 100 independent realizations were performed at small Atwood number and unit Prandtl number with a spatial resolution of $2048\times8193$ grid points. Our main focus is on the temporal evolution and the scaling behavior of global quantities and of small-scale turbulence properties. Our results show that the buoyancy force balances the inertial force at all scales below the integral length scale and thus validate the basic force-balance assumption of the Bolgiano-Obukhov scenario in 2D RT turbulence. It is further found that the Kolmogorov dissipation scale $η(t)\sim t^{1/8}$, the kinetic-energy dissipation rate $\varepsilon_u(t)\sim t^{-1/2}$, and the thermal dissipation rate $\varepsilon_θ(t)\sim t^{-1}$. All of these scaling properties are in excellent agreement with the theoretical predictions of the Chertkov model [Phys. Rev. Lett. \textbf{91}, 115001 (2003)]. We further discuss the emergence of intermittency and anomalous scaling for high order moments of velocity and temperature differences. The scaling exponents $ξ^r_p$ of the $p$th-order temperature structure functions are shown to saturate to $ξ^r_{\infty}\simeq0.78\pm0.15$ for the highest orders, $p\sim10$. The value of $ξ^r_{\infty}$ and the order at which saturation occurs are compatible with those of turbulent Rayleigh-Bénard (RB) convection [Phys. Rev. Lett. \textbf{88}, 054503 (2002)], supporting the scenario of universality of buoyancy-driven turbulence with respect to the different boundary conditions characterizing the RT and RB systems.
description: 17 pages, 17 figures, Accepted by Physics of Fluids