cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Our Rainbow Lives
Creators: name: Parsons, Matthew
name: Despott, Nathan
name: Power, Rosalie
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Our Rainbow Lives is an introduction to LGBTIQA+ identity, experiences, sexuality, gender and bodies for people with intellectual disability and their supporters.
Our Rainbow Lives is designed for supported reading. It works best if a person with a disability and a supporter read it together.
Most of the left-hand pages are written in plain language. The right-hand pages are written using easy-to-read language. This means that the text uses larger letters and there are pictures to assist supported readers.
Supporters should read the left-hand pages before supporting a person with disability to read the right-hand pages. In most cases, the ideas on the left and the right are the same but with more information for the support person to facilitate a conversation around the material.
Our Rainbow Lives is an introduction to what it means to be LGBTIQA+ and how to be supportive of LGBTIQA+ people. It should be used within a holistic sexuality and relationship program at an appropriate point where the necessary foundational education and support has occurred. It may also be appropriate to introduce this content in employment settings – where foundational education has occurred – to help a person with a disability understand standards of appropriate behaviour according to anti-discrimination legislation. NDIS providers have an obligation to provide inclusive services for LGBTIQA+ people and this booklet can help them to do so.
At the end of the book you will find additional resources for supporters as well as a glossary.

© Inclusion Melbourne and Rainbow Health Victoria 2021
title: The value of routine screening mammography in women aged 35 to 39 years in a symptomatic breast unit
Creators: name: Buckley, Anne
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Radioprotection / Radiation dose
subject: Mammography
subject: Biopsy
subject: Screening
subject: Health policy and practice
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To determine the cancer detection rate over a 5-year period in women aged 35-39 years attending a symptomatic breast clinic with a normal or benign clinical examination, as a result of the practice of performing bilateral screening mammography on...
Un canvi en la unió a la cromatina de la p38 fosforilada precedeix els canvis transcripcionals davant l'estrès oxidatiu
Creators: name: Camilleri-Robles, Carlos
name: Climent-Cantó, Paula
name: Llorens-Giralt, Palmira
name: Klein, Cecilia C.
name: Serras, Florenci
name: Corominas, Montserrat
Publisher: name: Zenodo
Year: 2024

description: This document contains the Catalan translation of the abstract and the graphical summary of the article “A shift in chromatin binding of phosphorylated p38 precedes transcriptional changes upon oxidative stress” by Camilleri-Robles et al. FEBS Letters (2024), https://doi.org/10.1002/1873-3468.15006
A white paper with legal recommendations - v. 2
Creators: name: Gliściński LL.M., Konrad
name: Lima, Francisco
Publisher: name: Zenodo
Year: 2023

description: The white paper presents legal recommendations from research conducted in the inDICEs project addressing policymakers in the cultural heritage field on European and national levels. The recommendations rely on recognising the socio-economic values generated in digital cultural heritage following the Culture 3.0 paradigm by Pier Luigi Sacco. This paradigm blurs the boundaries between producers and users. “Cultural producers and users are enabled to interchange roles in a wide range of possibilities” . It thus makes it necessary to redefine the role of copyright 1 itself and its normative shape in the new realm of the heritage sector. Traditionally, the regulatory approach places the artwork understood as an object of ownership in the centre of attention, together with the market mechanisms of its production and distribution, and treats CHI's activity as a marginal element of the system. In contrast, the white paper approach places the artwork as part of the cultural heritage at the centre and CHI's activity as an essential aspect to extract from this heritage the socio-economic values. The traditional approach deprives society of these benefits by insufficient consideration of these values.
title: Recall of unstructured radiology reports is significantly inferior to that of structured reports
Creators: name: Buckley, Bryan
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: eHealth
subject: Professional issues
subject: Management
subject: MR
subject: CT
subject: Ultrasound
subject: Outcomes analysis
subject: eLearning
subject: Technology assessment
subject: Education and training
subject: Image verification
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The majority of radiology reports comprise a “free-text” structure without headings and/or subheadings. An alternative to free text reporting is the structured report, which uses a uniform and consistent report template and typically uses...
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity
Creators: name: Han, G.W.
name: Slocum, S.T.
name: Huang, X.-P.
name: Zhu, L.
name: McCorvy, J.D.
name: Li, C.
name: Johansson, L.C.
name: Katritch, V.
name: Roth, B.L.
name: Grandner, J.M.
name: Tribo, A.R.
name: Cherezov, V.
name: Zaare, S.
name: Yous, S.
name: Patel, N.
name: Liu, W.
name: Stauch, B.
name: Weierstall, U.
name: Olsen, R.H.J.
name: Gati, C.
name: Batyuk, A.
name: Zatsepin, N.A.
name: Hao, S.
name: Stevens, R.C.
Publisher: name: Nature Publishing Group
Year: 2019

description: The human MT1 and MT2 melatonin receptors1,2 are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns3. Drug development efforts have targeted both receptors for the treatment of insomnia, circadian rhythm and mood disorders, and cancer3, and MT2 has also been implicated in type 2 diabetes4,5. Here we report X-ray free electron laser (XFEL) structures of the human MT2 receptor in complex with the agonists 2-phenylmelatonin (2-PMT) and ramelteon6 at resolutions of 2.8 Å and 3.3 Å, respectively, along with two structures of function-related mutants: H2085.46A (superscripts represent the Ballesteros–Weinstein residue numbering nomenclature7) and N862.50D, obtained in complex with 2-PMT. Comparison of the structures of MT2 with a published structure8 of MT1 reveals that, despite conservation of the orthosteric ligand-binding site residues, there are notable conformational variations as well as differences in [3H]melatonin dissociation kinetics that provide insights into the selectivity between melatonin receptor subtypes. A membrane-buried lateral ligand entry channel is observed in both MT1 and MT2, but in addition the MT2 structures reveal a narrow opening towards the solvent in the extracellular part of the receptor. We provide functional and kinetic data that support a prominent role for intramembrane ligand entry in both receptors, and suggest that there might also be an extracellular entry path in MT2. Our findings contribute to a molecular understanding of melatonin receptor subtype selectivity and ligand access modes, which are essential for the design of highly selective melatonin tool compounds and therapeutic agents. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
title: Comparison of spoiled gradient recalled acquisition and spin echo magnetic resonance images in detection of pituitary ACTH secreting adenoma
Creators: name: Kidzinski, Rafal
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: MR
subject: Comparative studies
subject: Technical aspects
subject: Endocrine disorders

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The objective of the study was to compare the efficacy of spoiled gradient recalled acquisition (SPGR) and fast spin echo (FSE) magnetic resonance images in detection of pituitary ACTH secreting adenoma. SPGR images have the potential to improve...
(103393) Henry Harold Daniel Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Structural basis of ligand recognition at the human MT1 melatonin receptor
Creators: name: Grandner, J.M.
name: Batyuk, A.
name: Madsen, C.
name: Stauch, B.
name: Grant, T.D.
name: Slocum, S.T.
name: Katritch, V.
name: Shiriaeva, A.
name: Brehm, W.
name: Johansson, L.C.
name: Han, G.W.
name: Tribo, A.R.
name: Patel, N.
name: Zhu, L.
name: Cherezov, V.
name: Yous, S.
name: Liu, W.
name: Gati, C.
name: Michaelian, N.
name: Roth, B.L.
name: White, T.A.
name: Olsen, R.H.J.
name: Ishchenko, A.
name: Weierstall, U.
name: Stevens, R.C.
name: Huang, X.-P.
name: McCorvy, J.D.
Publisher: name: Nature Publishing Group
Year: 2019

description: Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms1 by synchronization to environmental cues and is involved in diverse physiological processes2 such as the regulation of blood pressure and core body temperature, oncogenesis, and immune function3. Melatonin is formed in the pineal gland in a light-regulated manner4 by enzymatic conversion from 5-hydroxytryptamine (5-HT or serotonin), and modulates sleep and wakefulness5 by activating two high-affinity G-protein-coupled receptors, type 1A (MT1) and type 1B (MT2)3,6. Shift work, travel, and ubiquitous artificial lighting can disrupt natural circadian rhythms; as a result, sleep disorders affect a substantial population in modern society and pose a considerable economic burden7. Over-the-counter melatonin is widely used to alleviate jet lag and as a safer alternative to benzodiazepines and other sleeping aids8,9, and is one of the most popular supplements in the United States10. Here, we present high-resolution room-temperature X-ray free electron laser (XFEL) structures of MT1 in complex with four agonists: the insomnia drug ramelteon11, two melatonin analogues, and the mixed melatonin–serotonin antidepressant agomelatine12,13. The structure of MT2 is described in an accompanying paper14. Although the MT1 and 5-HT receptors have similar endogenous ligands, and agomelatine acts on both receptors, the receptors differ markedly in the structure and composition of their ligand pockets; in MT1, access to the ligand pocket is tightly sealed from solvent by extracellular loop 2, leaving only a narrow channel between transmembrane helices IV and V that connects it to the lipid bilayer. The binding site is extremely compact, and ligands interact with MT1 mainly by strong aromatic stacking with Phe179 and auxiliary hydrogen bonds with Asn162 and Gln181. Our structures provide an unexpected example of atypical ligand entry for a non-lipid receptor, lay the molecular foundation of ligand recognition by melatonin receptors, and will facilitate the design of future tool compounds and therapeutic agents, while their comparison to 5-HT receptors yields insights into the evolution and polypharmacology of G-protein-coupled receptors.
Are rogue waves really unexpected?
Creators: name: Fedele, Francesco
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: An unexpected wave is defined by Gemmrich & Garrett (2008) as a wave that is much taller than a set of neighboring waves. Their definition of "unexpected" refers to a wave that is not anticipated by a casual observer. Clearly, unexpected waves defined in this way are predictable in a statistical sense. They can occur relatively often with a small or moderate crest height, but large unexpected waves that are rogue are rare. Here, this concept is elaborated and statistically described based on a third-order nonlinear model. In particular, the conditional return period of an unexpected wave whose crest exceeds a given threshold is developed. This definition leads to greater return periods or on average less frequent occurrences of unexpected waves than those implied by the conventional return periods not conditioned on a reference threshold. Ultimately, it appears that a rogue wave that is also unexpected would have a lower occurrence frequency than that of a usual rogue wave. As specific applications, the Andrea and WACSIS rogue wave events are examined in detail. Both waves appeared without warning and their crests were nearly $2$-times larger than the surrounding $O(10)$ wave crests, and thus unexpected. The two crest heights are nearly the same as the threshold~$h_{0.3\cdot10^{6}}\sim1.6H_{s}$ exceeded on average once every~$0.3\cdot 10^{6}$ waves, where $H_s$ is the significant wave height. In contrast, the Andrea and WACSIS events, as both rogue and unexpected, would occur slightly less often and on average once every~$3\cdot10^{6}$ and~$0.6\cdot10^6$ waves respectively.
Density-Dependent Gauge Field with Raman Lattices
Creators: name: Cheng, Xiang-Can
name: Wang, Zong-Yao
name: Zhang, Jinyi
name: Chen, Shuai
name: Nie, Xiaotian
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The study of the gauge field is an everlasting topic in modern physics. Spin-orbit coupling is a powerful tool in ultracold atomic systems, resulting in an artificial gauge field that can be easily manipulated and observed in a tabletop environment. Combining optical Raman lattices and atom-atom interaction, the artificial gauge field can be made density-dependent. In this work, we propose a straightforward way to engineer one-dimensional density-dependent gauge field in a Bose-Hubbard model in spin-orbit coupled Raman lattices. Next, we study the model from two perspectives: few-body quantum walk dynamics and many-body ground state. In the first perspective, we show that large spin-flipped tunneling can lead to a deep two-body bound state. In the second perspective, mean-field and density matrix renormalization group (DMRG) calculations consistently reveal three different phases, i.e. the Mott insulator phase, the superfluid phase, and the magnetic superfluid phase. Finally, we discuss the experimental protocol with Raman lattices based on existing experimental platforms.
description: Phys. Rev. A 111, 013319
Ultra-large library docking for discovering new chemotypes
Creators: name:  Che, T.
name:  Balius, T.E.
name:  O’Meara, M.J.
name:  Levit, A.
name: Tolmachova, K.
name: Tolmachev, A.A.
name: Lyu, J.
name:  Algaa, E.
name:  Singh, I.
name: Irwin, J.J.
name: Shoichet, B.K.
name: Roth, B.L.
name:  Moroz, Y.S.
name:  Wang, S.
Publisher: name: Nature Publishing Group
Year: 2019

description: Despite intense interest in expanding chemical space, libraries containing hundreds-of-millions to billions of diverse molecules have remained inaccessible. Here we investigate structure-based docking of 170 million make-on-demand compounds from 130 well-characterized reactions. The resulting library is diverse, representing over 10.7 million scaffolds that are otherwise unavailable. For each compound in the library, docking against AmpC β-lactamase (AmpC) and the D 4 dopamine receptor were simulated. From the top-ranking molecules, 44 and 549 compounds were synthesized and tested for interactions with AmpC and the D 4 dopamine receptor, respectively. We found a phenolate inhibitor of AmpC, which revealed a group of inhibitors without known precedent. This molecule was optimized to 77 nM, which places it among the most potent non-covalent AmpC inhibitors known. Crystal structures of this and other AmpC inhibitors confirmed the docking predictions. Against the D 4 dopamine receptor, hit rates fell almost monotonically with docking score, and a hit-rate versus score curve predicted that the library contained 453,000 ligands for the D 4 dopamine receptor. Of 81 new chemotypes discovered, 30 showed submicromolar activity, including a 180-pM subtype-selective agonist of the D 4 dopamine receptor.
Monolayer Magnetic Metal with Scalable Conductivity
Creators: name: Parfenov, Oleg E.
name: Averyanov, Dmitry V.
name: Sokolov, Ivan S.
name: Mihalyuk, Alexey N.
name: Kondratev, Oleg A.
name: Taldenkov, Alexander N.
name: Tokmachev, Andrey M.
name: Storchak, Vyacheslav G.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: 2D magnets have emerged as a class of materials highly promising for studies of quantum phenomena and applications in ultra-compact spintronics. Current research aims at design of 2D magnets with particular functional properties. A formidable challenge is to produce metallic monolayers: the material landscape of layered magnetic systems is strongly dominated by insulators; rare metallic magnets, such as Fe3GeTe2, become insulating as they approach the monolayer limit. Here, electron transport measurements demonstrate that the recently discovered 2D magnet GdAlSi - graphene-like AlSi layers coupled to layers of Gd atoms - remains metallic down to a single monolayer. Band structure analysis indicates the material to be an electride, which may stabilize the metallic state. Remarkably, the sheet conductance of 2D GdAlSi is proportional to the number of monolayers - a manifestation of scalable conductivity. The GdAlSi layers are epitaxially integrated with silicon, facilitating applications in electronics.
title: MRI-guided high-intensity focused ultrasound: a new first-line technique in the treatment of osteoid osteoma?
Creators: name: Napoli, Alessandro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Musculoskeletal bone
subject: MR
subject: Ablation procedures

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Osteoid Osteoma (OO) is a benign tumor that mainly affects pediatric population. The impact on quality of life is considerable, since OO is typically associated with nocturnal pain and limitations ineveryday or sportive activity. Currently, the most...
Stability Analysis of Axial Reflection Symmetric Spacetime
Creators: name: Sharif, M.
name: Bhatti, M. Zaeem Ul Haq
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: In this paper, we explore instability regions of non-static axial reflection symmetric spacetime with anisotropic source in the interior. We impose linear perturbation on the Einstein field equations and dynamical equations to establish the collapse equation. The effects of different physical factors like energy density and anisotropic stresses on the instability regions are studied under Newtonian and post-Newtonian limits. We conclude that stiffness parameter has a significant role in this analysis while the reflection terms increase instability ranges of non-static axial collapse.
description: 21 Pages, title is changed, some other changes are incorporated
(103388) Adelaide Elizabeth Phoebe Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Zeit und Geld
title: Bericht zur Jahreskonferenz 2009 von WIDE Europe in Basel
titleType: Subtitle
Creators: name: Fankhauser, Lilian
Publisher: name: Humboldt-Universität zu Berlin
Year: 2009
Subjects: subject: Care
subject: Zeit
subject: Alter
subject: Wirtschaft
subject: 300 Sozialwissenschaften
subject: 361 Soziale Probleme und Sozialhilfe im Allgemeinen

description: Wir können Fast Food produzieren und konsumieren, um in immer kürzerer Zeit das Funktionieren unseres Körpers sicher zu stellen – aber wir können „Care“, das Sich-Kümmern um und Sorgen für andere Menschen, nicht immer weiter zeitlich reduzieren: „Fast Care“, so das Fazit der Konferenz zu Care Ökonomie, können wir uns längerfristig gar nicht leisten.
title: Efficacy of ultrasound elastography in diagnosing thyroid lesions and correlation with FNAC or biopsy
Creators: name: Phansalkar, Dilip
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Thyroid / Parathyroids
subject: Head and neck
subject: Elastography
subject: Ultrasound
subject: Efficacy studies
subject: Diagnostic procedure
subject: Tissue characterisation
subject: Endocrine disorders

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Thyroid lesions are common radiological findings in both asymptomatic and symptomatic patients and evaluation of these lesions remains a diagnostic challenge. The main concern for managing thyroid nodules is to exclude malignant lesions, which...
Topological Charge Quadrupole Protected by Spin-Orbit U(1) Quasi-Symmetry in Antiferromagnet NdBiPt
Creators: name: Zhang, Ao
name: Chen, Xiaobing
name: Li, Jiayu
name: Liu, Pengfei
name: Liu, Yuntian
name: Liu, Qihang
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The interplay of symmetry and topology in crystal solids has given rise to various elementary excitations as quasiparticles. Among these, those with significant Berry-phase-related transport responses are of particular interest. Here, we predict a new type of quasiparticle called topological charge quadruple (TCQ), which is analogous to a charge quadrupole but consists of two closely-packed pairs of Weyl points in momentum space, specifically in a half-Heusler antiferromagnet NdBiPt. Interestingly, the TCQ is protected by the spin-orbit $U(1)$ quasi-symmetry, rather than any exact crystallographic symmetries. This quasi-symmetry restricts the energy splitting induced by symmetry-lowering perturbations to a second-order effect. Furthermore, the closely located Berry curvature sources and sinks in the TCQ lead to a large Berry curvature dipole, resulting in a significant nonlinear Hall effect. Our work opens an avenue for designing novel quasiparticles using quasi-symmetries and developing materials with enhanced nonlinear responses.
description: 4 figures
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Creators: name: Gloriam, D.E.
name: Hauser, A.S.
name: Roth, B.L.
name: Haugaard-Kedström, L.M.
name: Foster, S.R.
name: Vedel, L.
name: Gavin, A.C.
name: Penn, R.B.
name: Strachan, R.T.
name: Nayak, A.P.
name: Bräuner-Osborne, H.
name: Huang, X.-P.
name: Shah, S.D.
Publisher: name: Cell Press
Year: 2019

description: The peptidergic system is the most abundant network of ligand-receptor-mediated signaling in humans. However, the physiological roles remain elusive for numerous peptides and more than 100 G protein-coupled receptors (GPCRs). Here we report the pairing of cognate peptides and receptors. Integrating comparative genomics across 313 species and bioinformatics on all protein sequences and structures of human class A GPCRs, we identify universal characteristics that uncover additional potential peptidergic signaling systems. Using three orthogonal biochemical assays, we pair 17 proposed endogenous ligands with five orphan GPCRs that are associated with diseases, including genetic, neoplastic, nervous and reproductive system disorders. We also identify additional peptides for nine receptors with recognized ligands and pathophysiological roles. This integrated computational and multifaceted experimental approach expands the peptide-GPCR network and opens the way for studies to elucidate the roles of these signaling systems in human physiology and disease. Video Abstract: Features learned from comparative sequence and structural analyses enabled prediction of peptide ligands for orphan GPCRs that, when coupled with functional validation, expose physiologically relevant signaling systems. © 2019 The Author(s)
Survey Instrument - 2nd National Survey of Australian Teachers of Sexuality Education 2018
Creators: name: Ezer, Paulina
name: Power, Jennifer
name: Jones, Tiffany
name: Fisher, Christopher
Publisher: name: La Trobe
Year: 2020
Subjects: subject: 169999 Studies in Human Society not elsewhere classified
subject: FOS: Sociology

description: This survey instrument was used to collect data from Australian teachers of sexuality education on their characteristics; training in, delivery of, and views and opinions on sexuality education; and teacher supports.
Supermembrane limit of Yang-Mills theory
Creators: name: Lechtenfeld, Olaf
name: Popov, Alexander D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider Yang-Mills theory with $N{=}1$ super translation group in eleven auxiliary dimensions as the structure group. The gauge theory is defined on a direct product manifold $Σ_3\times S^1$, where $Σ_3$ is a three-dimensional Lorentzian manifold and $S^1$ is a circle. We show that in the infrared limit, when the metric on $S^1$ is scaled down, the Yang-Mills action supplemented by a Wess-Zumino-type term reduces to the action of an M2-brane.
description: 1+6 pages
title: Evolution of brain lesions in patients with antiphospholipid syndrome: a longitudinal MRI study
Creators: name: Svrckova, Patricia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: CNS
subject: Vascular
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Angiography
subject: Treatment effects
subject: Embolism / Thrombosis
subject: Haemorrhage

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Patients with antiphospholipid syndrome (APS) are prone to a number of systemic complications resulting from a prothrombotic state, and the brain is no exception. The usual presentation is with stroke-like symptoms in a young patient, in contrast to...
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
Creators: name: Olsen, R.H.J.
name: Singh, D.
name: Cockrell, A.S.
name: Strachan, R.T.
name: White, K.
name: English, J.G.
name: Wacker, D.
name: Lansu, K.
name: Roth, B.L.
name: Patel, M.
Publisher: name: Cell Press
Year: 2019

description: Directed evolution, artificial selection toward designed objectives, is routinely used to develop new molecular tools and therapeutics. Successful directed molecular evolution campaigns repeatedly test diverse sequences with a designed selective pressure. Unicellular organisms and their viral pathogens are exceptional for this purpose and have been used for decades. However, many desirable targets of directed evolution perform poorly or unnaturally in unicellular backgrounds. Here, we present a system for facile directed evolution in mammalian cells. Using the RNA alphavirus Sindbis as a vector for heredity and diversity, we achieved 24-h selection cycles surpassing 10−3 mutations per base. Selection is achieved through genetically actuated sequences internal to the host cell, thus the system's name: viral evolution of genetically actuating sequences, or “VEGAS.” Using VEGAS, we evolve transcription factors, GPCRs, and allosteric nanobodies toward functional signaling endpoints each in less than 1 weeks’ time. © 2019 Elsevier Inc.The VEGAS system is a platform for directed evolution, a method for engineering DNA sequences, in mammalian cells. The system is highly mutagenic, facile, and self-contained, requiring no in vitro handling during evolution cycles. As a result, robust evolution campaigns can be run within the context of a mammalian cell signaling environment. We perform three such campaigns as a proof-of-concept: evolving a transcription factor, a G-protein coupled receptor, and llama-derived nanobodies toward specific in vivo activities. © 2019 Elsevier Inc.
(103390) Maurice George Meade-King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism
Creators: name: Zhang, G.
name:  McCorvy, J.D.
name:  Kozikowski, A.P.
name:  Shen, S.
name:  Cheng, J.
name:  Roth, B.L.
Publisher: name: Elsevier Masson SAS
Year: 2019

description: A new series of fluorinated 5-HT2C agonists were designed and synthesized on the basis of our previous work on 2-phenylcyclopropylmethylamines as a potential approach for the treatment of central nervous system disorders. Key fluorinated cyclopropane moieties were constructed through transition metal catalyzed [2 + 1]-cycloaddition of aromatic vinyl fluorides, and the absolute stereochemistry of the representative compound (–)-21a was established. Functional activity measuring calcium flux at 5-HT2 receptors reveals high potency for compounds (+)-21a-d. In particular, (+)-21b had no detectable 5-HT2B agonism and displayed reasonable selectivity against 5-HT2A. Molecular docking studies were further performed to explain the compounds’ possible binding poses to the 5-HT2C receptor. © 2019
Charged Q-balls in gauge mediated SUSY breaking models
Creators: name: Hong, Jeong-Pyong
name: Kawasaki, Masahiro
name: Yamada, Masaki
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: It is known that after Affleck-Dine baryogenesis, spatial inhomogeneities of Affleck-Dine field grow into non-topological solitons called Q-balls. In gauge mediated SUSY breaking models, sufficiently large Q-balls with baryon charge are stable while Q-balls with lepton charge can always decay into leptons. For a Q-ball that carries nonzero $B$ and $L$ charges, the difference between the baryonic component and the leptonic component in decay rate may induce nonzero electric charge on the Q-ball. This implies that charged Q-ball, also called gauged Q-ball, may emerge in our universe. In this paper, we investigate two complex scalar fields, a baryonic scalar field and a leptonic one, in an Abelian gauge theory. We find stable solutions of gauged Q-balls for different baryon and lepton charges. Those solutions shows that a Coulomb potential arises and the Q-ball becomes electrically charged as expected. It is energetically favored that some amount of leptonic component decays, but there is an upper bound on its amount due to the Coulomb force. The baryonic decay also becomes possible by virtue of electrical repulsion and we find the condition to suppress it so that the charged Q-balls can survive in the universe.
description: 21 pages, 9 figures
title: Results of diffusion-weighted and dynamic contrast-enhanced MRI as biomarkers for evaluation of breast cancer response to neoadjuvant chemotherapy
Creators: name: Shliapkina, Olga
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Oncology
subject: MR
subject: Treatment effects
subject: Chemotherapy
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Neoadjuvant chemotherapy (NAC) often allows downstaging of local advanced cancer and improves the respectability and feasibility of breast-conserving surgery by reducing the size of the tumor (1). The achievement of a pathological complete response...
title: Assessment of response to neo-adjuvant chemotherapy in breast carcinoma using shear wave elastography
Creators: name: Ramalingam, Vidyasagar
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Elastography
subject: Diagnostic procedure
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Breast cancer accounts for one in ten of all new cancers diagnosed worldwide every year. The developing countries account for 45% of the global burden, but the incidence is rapidly rising in the developing countries [1, 2]. Breast cancer management...
title: MRI evaluation of knee osteochondritis dissecans treated with a cell-free biomimetic osteochondral scaffold vs microfracture technique: a multicenter randomised experience
Creators: name: Tonetti, Laura
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal joint
subject: Musculoskeletal system
subject: MR
subject: Surgery

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The purposes of our study were 1) to compare two different surgical approaches, biomimetic osteochondral scaffold implantation and microfracture (MF), in treatment of knee osteochondritis dissecans (OCD) and 2) to evaluate articular...
title: Elasticity characterisation of vastus lateralis muscle by ultrasound quasi-static elastography
Creators: name: Santos, Rute
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal soft tissue
subject: Elastography
subject: Experimental investigations
subject: Image registration

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To validate the use of QSE for muscle elasticity mapping as a possible clinical and quantitative tool and to compare quantitatively the QSE mapping obtained in the vastus lateralis muscles of young adults when submitted to a program of...
title: Thickness and echo-intensity characterisation of quadriceps muscle by ultrasound
Creators: name: Santos, Rute
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal soft tissue
subject: Ultrasound
subject: Experimental investigations
subject: Image registration

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To characterise the thickness and echo-intensity of the quadriceps femoris muscle and analyse its relationship with gender, practice of sports, number of training and practice...
An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking
Creators: name: Sainz, E.
name: Pagani, L.
name: Risso, D.
name: Kozlitina, J.
name: Frigerio-Domingues, C.
name: Luiselli, D.
name: Lansu, K.
name: Olsen, R.H.J.
name: Roth, B.
name: Barik, A.
name: Wooding, S.
name: Niaura, R.
name: Drayna, D.
name: Kirchner, T.
Publisher: name: Public Library of Science
Year: 2019

description: In the U.S., more than 80% of African-American smokers use mentholated cigarettes, compared to less than 30% of Caucasian smokers. The reasons for these differences are not well understood. To determine if genetic variation contributes to mentholated cigarette smoking, we performed an exome-wide association analysis in a multiethnic population-based sample from Dallas, TX (N = 561). Findings were replicated in an independent cohort of African Americans from Washington, DC (N = 741). We identified a haplotype of MRGPRX4 (composed of rs7102322[G], encoding N245S, and rs61733596[G], T43T), that was associated with a 5-to-8 fold increase in the odds of menthol cigarette smoking. The variants are present solely in persons of African ancestry. Functional studies indicated that the variant G protein-coupled receptor encoded by MRGPRX4 displays reduced agonism in both arrestin-based and G protein-based assays, and alteration of agonism by menthol. These data indicate that genetic variation in MRGPRX4 contributes to inter-individual and inter-ethnic differences in the preference for mentholated cigarettes, and that the existence of genetic factors predisposing vulnerable populations to mentholated cigarette smoking can inform tobacco control and public health policies.
(103386) Olive Margaret Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An unexpectedly low-redshift excess of Swift gamma-ray burst rate
Creators: name: Yu, H.
name: Wang, F. Y.
name: Dai, Z. G.
name: Cheng, K. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Gamma-ray bursts (GRBs) are the most violent explosions in the Universe and can be used to explore the properties of high-redshift universe. It is believed that the long GRBs are associated with the deaths of massive stars. So it is possible to use GRBs to investigate the star formation rate (SFR). In this paper, we use Lynden-Bell's $c^-$ method to study the luminosity function and rate of \emph{Swift} long GRBs without any assumptions. We find that the luminosity of GRBs evolves with redshift as $L(z)\propto g(z)=(1+z)^k$ with $k=2.43_{-0.38}^{+0.41}$. After correcting the redshift evolution through $L_0(z)=L(z)/g(z)$, the luminosity function can be expressed as $ψ(L_0)\propto L_0^{-0.14\pm0.02}$ for dim GRBs and $ψ(L_0)\propto L_0^{-0.70\pm0.03}$ for bright GRBs, with the break point $L_{0}^{b}=1.43\times10^{51}~{\rm erg~s^{-1}}$. We also find that the formation rate of GRBs is almost constant at $z<1.0$ for the first time, which is remarkably different from the SFR. At $z>1.0$, the formation rate of GRB is consistent with the SFR. Our results are dramatically different from previous studies. Some possible reasons for this low-redshift excess are discussed. We also test the robustness of our results with Monte Carlo simulations. The distributions of mock data (i.e., luminosity-redshift distribution, luminosity function, cumulative distribution and $\log N-\log S$ distribution) are in good agreement with the observations. Besides, we also find that there are remarkable difference between the mock data and the observations if long GRB are unbiased tracers of SFR at $z<1.0$.
description: 33 pages, 10 figures, 1 table, accepted by ApJS
BINDy -- Bayesian identification of nonlinear dynamics with reversible-jump Markov-chain Monte-Carlo
Creators: name: Champneys, Max D.
name: Rogers, Timothy J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Dynamical Systems (math.DS)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Model parsimony is an important \emph{cognitive bias} in data-driven modelling that aids interpretability and helps to prevent over-fitting. Sparse identification of nonlinear dynamics (SINDy) methods are able to learn sparse representations of complex dynamics directly from data, given a basis of library functions. In this work, a novel Bayesian treatment of dictionary learning system identification, as an alternative to SINDy, is envisaged. The proposed method -- Bayesian identification of nonlinear dynamics (BINDy) -- is distinct from previous approaches in that it targets the full joint posterior distribution over both the terms in the library and their parameterisation in the model. This formulation confers the advantage that an arbitrary prior may be placed over the model structure to produce models that are sparse in the model space rather than in parameter space. Because this posterior is defined over parameter vectors that can change in dimension, the inference cannot be performed by standard techniques. Instead, a Gibbs sampler based on reversible-jump Markov-chain Monte-Carlo is proposed. BINDy is shown to compare favourably to ensemble SINDy in three benchmark case-studies. In particular, it is seen that the proposed method is better able to assign high probability to correct model terms.
Surface group representations to $SL(2,{\mathbb C})$ and Higgs bundles with smooth spectral data
Creators: name: Wentworth, Richard A.
name: Wolf, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We show that for every nonelementary representation of a surface group into $SL(2,{\mathbb C})$ there is a Riemann surface structure such that the Higgs bundle associated to the representation lies outside the discriminant locus of the Hitchin fibration.
description: 15 pages. Revised version. To appear in Geometry and Topology
β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists
Creators: name:  Roth, B.L.
name:  Dockendorff, C.
name: Rosas, R.
name:  Huang, X.-P.
Publisher: name: American Chemical Society
Year: 2019

description: The concept recently postulated by Stein and co-workers (Science 2017, 355, 966) that mu opioid receptor (MOR) agonists possessing amines with attenuated basicity show pH-dependent activity and can selectively act at damaged, low pH tissues has been additionally supported by in vitro studies reported here. We synthesized and tested analogs of fentanyl possessing one or two fluorine atoms at the beta position of the phenethylamine side chain, with additional fluorines optionally added to the benzene ring of the side chain. These compounds were synthesized in 1 to 3 steps from commercial building blocks. The novel bis-fluorinated analog RR-49 showed superior pH sensitivity, with full efficacy relative to DAMGO, but with 19-fold higher potency (IC50) in a MOR cAMP assay at pH 6.5 versus 7.4. Such compounds hold significant promise as analgesics for inflammatory pain with reduced abuse potential.
MPEC 2023-T200 : 2023 TA8
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 TA8

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Pulmonary reperfusion injury following right ventricular outflow tract stenting
Creators: name: GARCIA, OMAR
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Interventional vascular
subject: Conventional radiography
subject: Catheter arteriography
subject: Stents

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease (CHD) and represents 5% to 7% of all CHD. TOF has an estimated incidence of 0.5/1000 live births. [1,2]. It is also the most frequent complex CHD in adulthood. TOF is a...
(103387) Christopher David Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets
Creators: name: Sassano, M.F.
name: Roth, B.L.
name: Lyu, J.
name: Karpiak, J.
name: Shoichet, B.K.
name: Huang, X.-P.
name: Weiss, D.R.
Publisher: name: American Chemical Society
Year: 2018

description: To investigate large library docking's ability to find molecules with joint activity against on-targets and selectivity versus antitargets, the dopamine D2 and serotonin 5-HT2A receptors were targeted, seeking selectivity against the histamine H1 receptor. In a second campaign, Î°-opioid receptor ligands were sought with selectivity versus the μ-opioid receptor. While hit rates ranged from 40% to 63% against the on-targets, they were just as good against the antitargets, even though the molecules were selected for their putative lack of binding to the off-targets. Affinities, too, were often as good or better for the off-targets. Even though it was occasionally possible to find selective molecules, such as a mid-nanomolar D2/5-HT2A ligand with 21-fold selectivity versus the H1 receptor, this was the exception. Whereas false-negatives are tolerable in docking screens against on-targets, they are intolerable against antitargets; addressing this problem may demand new strategies in the field. © 2018 American Chemical Society.