cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Redefining hypoglycemia in clinical trials: Validation of definitions recently adopted by the American Diabetes Association/European Association for the study of diabetes
Creators: name: Bardtrum, L.
name: Tutkunkardas, D.
name: Hansen, C.T.
name: Ratner, R.
name: Buse, J.B.
name: Heller, S.R.
name: Seaquist, E.
name: Moses, A.C.
Publisher: name: American Diabetes Association Inc.
Year: 2020

description: OBJECTIVE: To determine if the International Hypoglycaemia Study Group (IHSG) level 2 low glucose definition can identify clinically relevant hypoglycemia in clinical trials and offer value as an end point for future trials. RESEARCH DESIGN AND METHODS: A post hoc analysis was performed of the SWITCH (SWITCH 1: n = 501, type 1 diabetes; SWITCH 2: n = 721, type 2 diabetes) and DEVOTE (n = 7,637, type 2 diabetes) trials utilizing the IHSG low glucose definitions. Patients in all trials were randomized to either insulin degludec or insulin glargine 100 units/mL. In the main analysis, the following definitions were compared: 1) American Diabetes Association (ADA) 2005 (plasma glucose [PG] confirmed ≤3.9 mmol/L with symptoms); and 2) IHSG level 2 (PG confirmed <3.0 mmol/L, independent of symptoms). RESULTS: In SWITCH 2, the estimated rate ratios of hypoglycemic events indicated increasing differences between treatments with decreasing PG levels until 3.0 mmol/L, following which no additional treatment differences were observed. Similar results were observed for the SWITCH 1 trial. In SWITCH 2, the IHSG level 2 definition produced a rate ratio that was lower than the ADA 2005 definition. CONCLUSIONS: The IHSG level 2 definition was validated in a series of clinical trials, demonstrating its ability to discriminate between basal insulins. This definition is therefore recommended to be uniformly adopted by regulatory bodies and used in future clinical trials.
(101410) Vincent Amcotts Massingberd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101404) Edward Henry Maish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Valsalva sinus aneurysms: radiologic assessment with multidetector CT
Creators: name: Ibáñez Caturla, Santiago
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Arteries / Aorta
subject: Cardiovascular system
subject: Vascular
subject: CT
subject: Image manipulation / Reconstruction
subject: Education
subject: eLearning
subject: Aneurysms
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe normal anatomy of Valsalva sinuses and their appearance in multidetector computed tomography (MDCT) To review aneurysmal pathology with emphasis on imaging findings relevant for treatment planning To outline the importance of...
title: Percutaneous treatment for Herpes Zoster: new hopes...
Creators: name: Brunner, Philippe
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional non-vascular
subject: Neuroradiology peripheral nerve
subject: CT
subject: Percutaneous
subject: Education
subject: Puncture
subject: Acute
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to: Brieflydiscuss the epidemiology, pathophysiology and clinical presentation of Herpes Zoster. Assess the Herpes Zoster main complication: Post-Herpetic Neuralgia. Explain and illustrate a powerful...
(101407) Minnie Margaret Maish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Lacunaryx: Computing bounded-degree factors of lacunary polynomials
Creators: name: Grenet, Bruno
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Software (cs.MS)
subject: Symbolic Computation (cs.SC)
subject: FOS: Computer and information sciences

description: In this paper, we report on an implementation in the free software Mathemagix of lacunary factorization algorithms, distributed as a library called Lacunaryx. These algorithms take as input a polynomial in sparse representation, that is as a list of nonzero monomials, and an integer $d$, and compute its irreducible degree-$\le d$ factors. The complexity of these algorithms is polynomial in the sparse size of the input polynomial and $d$.
description: 6 pages
title: Pediatric intestinal malrotation in Upper Gastrointestinal Series: key points for diagnosis
Creators: name: Terranova, Maria Chiara
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Volvulus
subject: Education and training
subject: Acute
subject: Barium meal
subject: Fluoroscopy
subject: Paediatric
subject: Emergency
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this poster isto describe the golden features for the challenging diagnosis of intestinal malrotation in children, that predisposes to life-threatening volvulus [1]. Every radiologist should be familiar to the main imaging findings of...
title: Assessment of the evolution of hepatitis C with ARFI elastography in patients treated with new antiviral agents: a preliminary study
Creators: name: Ibáñez Caturla, Santiago
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Liver
subject: Ultrasound
subject: Treatment effects
subject: eLearning
subject: Education
subject: Cirrhosis
subject: Education and training
subject: Infection

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Hepatitis C virus (HCV) infection is an important public health concern since it represents one of the main causes of chronic liver disease. Even though thelong-term impact of infection is highly variable, HCV virus might be reponsible for liver...
Microvascular and cardiovascular outcomes according to renal function in patients treated with once-weekly exenatide: Insights from the EXSCEL trial
Creators: name: Jakuboniene, N.
name: Maggioni, A.P.
name: Angelyn Bethel, M.
name: Goodman, S.G.
name: Ohman, P.
name: Chan, J.C.
name: Buse, J.B.
name: Lopes, R.D.
name: Mentz, R.J.
name: Holman, R.R.
name: Merrill, P.
name: Hernandez, A.F.
name: Lokhnygina, Y.
name: Katona, B.
name: Bakris, G.L.
name: Iqbal, N.
name: Tankova, T.
Publisher: name: American Diabetes Association Inc.
Year: 2020

description: OBJECTIVE To evaluate the impact of once-weekly exenatide (EQW) on microvascular and cardiovascular (CV) outcomes by baseline renal function in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL). RESEARCH DESIGN AND METHODS Least squares mean difference (LSMD) in estimated glomerular filtration rate (eGFR) from baseline between the EQW and placebo groups was calculated for 13,844 participants. Cox regression models were used to estimate effects by group on incident macroalbuminuria, retinopathy, and major adverse CV events (MACE). Interval-censored time-to-event models estimated effects on renal composite 1 (40% eGFR decline, renal replacement, or renal death) and renal composite 2 (composite 1 variables plus macroalbuminuria). RESULTS EQW did not change eGFR significantly (LSMD 0.21 mL/min/1.73 m2 [95% CI 20.27 to 0.70]). Macroalbuminuria occurred in 2.2% of patients in the EQW group and in 2.5% of those in the placebo group (hazard ratio [HR] 0.87 [95% CI 0.70-1.07]). Neither renal composite was reduced with EQW in unadjusted analyses, but renal composite 2 was reduced after adjustment (HR 0.85 [95% CI 0.74-0.98]). Retinopathy rates did not differ by treatment group or in the HbA1c-lowering or prior retinopathy subgroups. CV outcomes in those with eGFR <60 mL/min/1.73 m2 did not differ by group. Those with eGFR ≥60 mL/min/1.73 m2 had nominal risk reductions for MACE, all-cause mortality, and CV death, but interactions by renal function group were significant for only stroke (HR 0.74 [95% CI 0.58-0.93]; P for interaction 5 0.035) and CV death (HR 1.08 [95% CI 0.85-1.38]; P for interaction 5 0.031). CONCLUSIONS EQW had no impact on unadjusted retinopathy or renal outcomes. CV risk was modestly reduced only in those with eGFR ≥60 mL/min/1.73 m2 in analyses unadjusted for multiplicity.
น้ำหมักชีวภาพกระตุ้นการเจริญและเพิ่มความต้านทานโรคในกล้วยหอมทอง
Creators: name: ธัญพิสิษฐ์ พวงจิก
Publisher: name: Thammasat University
Year: 2019
Subjects: Kluai Hom-Thong
Bio extract
Effective microorganism group

description: Thai Journal of Science and Technology, 8, 4, 345-354
A reassessment of the in situ formation of close-in super-Earths
Creators: name: Ogihara, Masahiro
name: Morbidelli, Alessandro
name: Guillot, Tristan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: A large fraction of stars host one or multiple close-in super-Earth planets. There is an active debate about whether these planets formed in situ or at greater distances from the central star and migrated to their current position. It has been shown that part of their observed properties (e.g., eccentricity distribution) can be reproduced by N-body simulations of in situ formation starting with a population of protoplanets of high masses and neglecting the effects of the disk gas. We plan to reassess the in situ formation of close-in super-Earths through more complete simulations. We performed N-body simulations of a population of small planetary embryos and planetesimals that include the effects of disk-planet interactions (e.g., eccentricity damping, type I migration). In addition, we also consider the accretion of a primitive atmosphere from a protoplanetary disk. We find that planetary embryos grow very quickly well before the gas dispersal, and thus undergo rapid inward migration, which means that one cannot neglect the effects of a gas disk when considering the in-situ formation of close-in super-Earths. Owing to their rapid inward migration, super-Earths reach a compact configuration near the disk's inner edge whose distribution of orbital parameters matches the observed close-in super-Earths population poorly. On the other hand, simulations including eccentricity damping, but no type I migration, reproduce the observed distributions better. Including the accretion of an atmosphere does not help reproduce the bulk architecture of observations. Interestingly, we find that the massive embryos can migrate inside the disk edge while capturing only a moderately massive hydrogen/helium atmosphere. By this process they avoid becoming giant planets. The bulk of close-in super-Earths cannot form in situ, unless type I migration is suppressed in the entire disk inside 1 AU.
description: 9 pages, 7 figures, accepted for publication in A&A
PPARA polymorphism influences the cardiovascular benefit of fenofibrate in type 2 diabetes: Findings from accord-lipid
Creators: name: Rotroff, D.M.
name: Mychaleckyj, J.C.
name: Paré, G.
name: Chew, E.Y.
name: Sjaarda, J.
name: Trischitta, V.
name: Morieri, M.L.
name: Sigal, R.J.
name: Buse, J.B.
name: Ginsberg, H.N.
name: Mercuri, L.
name: Marcovina, S.M.
name: Campbell, H.
name: Motsinger-Reif, A.A.
name: Prudente, S.
name: Lenzini, P.A.
name: Gerstein, H.C.
name: Patorno, E.
name: Pezzolesi, M.G.
name: Lovato, L.
name: Kraft, P.
name: Cresci, S.
name: Shah, H.S.
name: Wagner, M.J.
name: Doria, A.
name: Gao, H.
name: Pandolfi, A.
Publisher: name: American Diabetes Association Inc.
Year: 2020

description: The cardiovascular benefits of fibrates have been shown to be heterogeneous and to depend on the presence of atherogenic dyslipidemia. We investigated whether genetic variability in the PPARA gene, coding for the pharmacological target of fibrates (PPAR-a), could be used to improve the selection of patients with type 2 diabetes who may derive cardiovascular benefit from addition of this treatment to statins. We identified a common variant at the PPARA locus (rs6008845, C/T) displaying a study-wide significant influence on the effect of fenofibrate on major cardiovascular events (MACE) among 3,065 self-reported white subjects treated with simvastatin and randomized to fenofibrate or placebo in the ACCORD-Lipid trial. T/T homozygotes (36% of participants) experienced a 51% MACE reduction in response to fenofibrate (hazard ratio 0.49; 95% CI 0.34–0.72), whereas no benefit was observed for other genotypes (Pinteraction 5 3.7 3 1024). The rs6008845-by-fenofibrate interaction on MACE was replicated in African Americans from ACCORD (N 5 585, P 5 0.02) and in external cohorts (ACCORD-BP, ORIGIN, and TRIUMPH, total N 5 3059, P 5 0.005). Remarkably, rs6008845 T/T homozygotes experienced a cardiovascular benefit from fibrate even in the absence of atherogenic dyslipidemia. Among these individuals, but not among carriers of other genotypes, fenofibrate treatment was associated with lower circulating levels of CCL11—a proinflammatory and atherogenic chemokine also known as eotaxin (P for rs6008845-by-fenofibrate interaction 5 0.003). The GTEx data set revealed regulatory functions of rs6008845 on PPARA expression in many tissues. In summary, we have found a common PPARA regulatory variant that influences the cardiovascular effects of fenofibrate and that could be used to identify patients with type 2 diabetes who would derive benefit from fenofibrate treatment, in addition to those with atherogenic dyslipidemia.
title: Ultrasound guided posterior approach MRI arthrogram of the shoulder: a pictorial review
Creators: name: Paez, Diego
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Technical aspects
subject: Diagnostic procedure
subject: Contrast agent-other
subject: Ultrasound
subject: MR
subject: Musculoskeletal joint
subject: Interventional non-vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Describe the ultrasound-guided posterior approach and review the most common features on the MRI...
title: Drug Induced Pulmonary Toxicity: A diagnostic Conundrum!
Creators: name: Gudi, Sureshkumar
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Drugs / Reactions
subject: Chemotherapy
subject: CT-High Resolution
subject: Respiratory system
subject: Oncology

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To study the histopathological processes underlying pulmonary drug toxicity 2. Pictorial review of the imaging patterns on HRCT (High Resolution Computed tomography), of drug induced pulmonary toxicity by common agents at a tertiary cancer...
Derivation of the Biot-Savart equation from the Nonlinear Schrödinger equation
Creators: name: Bustamante, Miguel D.
name: Nazarenko, Sergey V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We present a systematic derivation of the Biot-Savart equation from the Nonlinear Schrödinger equation, in the limit when the curvature radius of vortex lines and the inter-vortex distance are much greater than the vortex healing length, or core radius. We derive the Biot-Savart equations in Hamiltonian form with Hamiltonian expressed in terms of vortex lines, $$ H= \frac{κ^2}{8 π}\int_{|{\bf s}-{\bf s}'|>ξ_*} \frac{d{\bf s} \cdot d {\bf s}'}{|{\bf s}-{\bf s}'|} \,,$$ with cut-off length $ξ_* \approx 0.3416293 /\sqrt{ρ_0},$ where $ρ_0$ is the background condensate density far from the vortex lines and $κ$ is the quantum of circulation.
Exploring the Possible Impact of Unbalanced Open-Label Drop-In of Glucose-Lowering Medications on EXSCEL Outcomes
Creators: name: Patel, R.A.
name: Mentz, R.J.
name: Schernthaner, G.
name: Hernandez, A.F.
name: Stevens, S.R.
name: Bethel, M.A.
name: Choi, J.
name: Gustavson, S.M.
name: Lecube, A.
name: Öhman, P.
name: Buse, J.B.
name: Holman, R.R.
name: Iqbal, N.
name: Lokhnygina, Y.
Publisher: name: Lippincott Williams and Wilkins
Year: 2020

description: Background: EXSCEL (Exenatide Study of Cardiovascular Event Lowering) assessed the impact of once-weekly exenatide 2 mg versus placebo in patients with type 2 diabetes mellitus, while aiming for glycemic equipoise. Consequently, greater drop-in of open-label glucose-lowering medications occurred in the placebo group. Accordingly, we explored the potential effects of their unbalanced use on major adverse cardiovascular events (MACE), defined as cardiovascular death, nonfatal myocardial infarction or nonfatal stroke, and all-cause mortality (ACM), given that some of these agents are cardioprotective. Methods: Cox hazard models were performed by randomized treatment for drug classes where >5% open-label drop-in glucose-lowering medication occurred, and for glucagon-like peptide-1 receptor agonists (GLP-1 RAs; 3.0%) using three methodologies: drop-in visit right censoring, inverse probability for treatment weighting (IPTW), and applying drug class risk reductions. Results: Baseline glucose-lowering medications for the 14 752 EXSCEL participants (73.1% with previous cardiovascular disease) did not differ between treatment groups. During median 3.2 years follow-up, open-label drop-in occurred in 33.4% of participants, more frequently with placebo than exenatide (38.1% versus 28.8%), with metformin (6.1% versus 4.9%), sulfonylurea (8.7% versus 6.9%), dipeptidyl peptidase-4 inhibitors (10.6% versus 7.5%), SGLT-2i (10.3% versus 8.1%), GLP-1 RA (3.4% versus 2.4%), and insulin (13.8% versus 9.4%). The MACE effect size was not altered meaningfully by right censoring, but the favorable HR for exenatide became nominally significant in the sulfonylurea and any glucose-lowering medication groups, while the ACM HR and p-values were essentially unchanged. IPTW decreased the MACE HR from 0.91 (P=0.061) to 0.85 (P=0.008) and the ACM HR from 0.86 (P=0.016) to 0.81 (P=0.012). Application of literature-derived risk reductions showed no meaningful changes in MACE or ACM HRs or P values, although simulations of substantially greater use of drop-in cardioprotective glucose-lowering agents demonstrated blunting of signal detection. Conclusions: EXSCEL-observed HRs for MACE and ACM remained robust after right censoring or application of literature-derived risk reductions, but the exenatide versus placebo MACE effect size and statistical significance were increased by IPTW. Effects of open-label drop-in cardioprotective medications need to be considered carefully when designing, conducting, and analyzing cardiovascular outcome trials of glucose-lowering agents under the premise of glycemic equipoise. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01144338.
A Mixed-Methods, Randomized Clinical Trial to Examine Feasibility of a Mindfulness-Based Stress Management and Diabetes Risk Reduction Intervention for African Americans with Prediabetes
Creators: name: Gaylord, S.A.
name: Bangdiwala, S.I.
name: Leniek, K.
name: Woods-Giscombe, C.L.
name: Yoo, J.
name: Lynch, C.
name: Smith, S.
name: Phillips, P.
name: Faurot, K.
name: Brintz, C.E.
name: Young, L.
name: Al-Barwani, S.
name: Li, Y.
name: Buse, J.B.
name: Mann, J.D.
Publisher: name: Hindawi Limited
Year: 2019

description: African Americans have disproportionately high rates of stress-related conditions, including diabetes and diabetes-related morbidity. Psychological stress may negatively influence engagement in risk-reducing lifestyle changes (physical activity and healthy eating) and stress-related physiology that increase diabetes risk. This study examined the feasibility of conducting a randomized trial comparing a novel mindfulness-based stress management program combined with diabetes risk-reduction education versus a conventional diabetes risk-reduction education program among African American adults with prediabetes and self-reported life stress. Participants were recruited in collaboration with community partners and randomized to the mindfulness-based diabetes risk-reduction education program for prediabetes (MPD; n = 38) or the conventional diabetes risk-reduction education program for prediabetes (CPD; n = 30). The mindfulness components were adapted from the Mindfulness-based Stress Reduction Program. The diabetes risk-reduction components were adapted from the Power to Prevent Program and the Diabetes Prevention Program. Groups met for eight weeks for 2.5 hours, with a half-day retreat and six-monthly boosters. Mixed-methods strategies were used to assess feasibility. Psychological, behavioral, and metabolic data were collected before the intervention and at three and six months postintervention to examine within-group change and feasibility of collecting such data in future clinical efficacy research. Participants reported acceptability, credibility, and cultural relevance of the intervention components. Enrollment of eligible participants (79%), intervention session attendance (76.5%), retention (90%), and postintervention data collection attendance (83%, 82%, and 78%, respectively) demonstrated feasibility, and qualitative data provided information to further enhance feasibility in future studies. Both groups exhibited an A1C reduction. MPD participants had reductions in perceived stress, BMI, calorie, carbohydrate and fat intake, and increases in spiritual well-being. Considering the high prevalence of diabetes and diabetes-related complications in African Americans, these novel findings provide promising guidance to develop a larger trial powered to examine efficacy of a mindfulness-based stress management and diabetes risk-reduction education program for African Americans with prediabetes.
(101401) Edward Nelson Maish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Ultrasound Guided Brachial Plexus block:An effective technique for Analgesia in Dialysis AV Fistula Interventions
Creators: name: Kumar, Aman
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Interventional non-vascular
subject: Neuroradiology peripheral nerve
subject: Catheter arteriography
subject: Ultrasound
subject: Catheter venography
subject: Angioplasty
subject: Treatment effects
subject: Education
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate efficacy of Ultrasound guided brachial Plexus block as an effective technique for analgesia in Dialysis AV Fistula...
Identifying individual risk rare variants using protein structure guided local tests (POINT)
Creators: name: Kuenemann, M.A.
name: Wu, M.C.
name: Buse, J.B.
name: Rotroff, D.M.
name: Chang, S.-M.
name: West, R.M.
name: Tzeng, J.-Y.
name: Lu, W.
name: Fourches, D.
name: Wagner, M.J.
name: Motsinger-Reif, A.A.
Publisher: name: Public Library of Science
Year: 2019

description: Rare variants are of increasing interest to genetic association studies because of their etiological contributions to human complex diseases. Due to the rarity of the mutant events, rare variants are routinely analyzed on an aggregate level. While aggregation analyses improve the detection of global-level signal, they are not able to pinpoint causal variants within a variant set. To perform inference on a localized level, additional information, e.g., biological annotation, is often needed to boost the information content of a rare variant. Following the observation that important variants are likely to cluster together on functional domains, we propose a protein structure guided local test (POINT) to provide variant-specific association information using structure-guided aggregation of signal. Constructed under a kernel machine framework, POINT performs local association testing by borrowing information from neighboring variants in the 3-dimensional protein space in a data-adaptive fashion. Besides merely providing a list of promising variants, POINT assigns each variant a p-value to permit variant ranking and prioritization. We assess the selection performance of POINT using simulations and illustrate how it can be used to prioritize individual rare variants in PCSK9, ANGPTL4 and CETP in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial data.
(101403) Sarah Margaret Elizabeth Evans
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The effects of dimer and oligomer separation on cell signaling in the EGFR family
Creators: name: Pattengale, Sarah Ruth
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: EGFR
Cell signaling
Receptor tyrosine kinases
Oligomer separation
Dimer separation
Receptor activation
Downstream signaling
Extracellular domain
Receptor regulation

description: The EGFR family of receptor tyrosine kinases (RTKs) includes EGFR, HER2/ErbB2, HER3/ErbB3, and HER4/ErbB. The EGFR family members play crucial roles in development and in regulating normal cellular processes. However, these receptors are found to be overexpressed or mutated in various cancers. The complete mechanism by which the EGFR family is autoregulated is still unknown. This work focuses on the role of the extracellular domain of EGFR family members on receptor activation, dimerization/oligomerization, and downstream signaling. We generated a system using designed ankyrin repeat proteins (DARPins) to study EGFR extracellular domain dimers of varying separation distances. We biochemically, cellularly, and structurally characterize interactions between HER3 and A30, an RNA that binds to the extracellular domain of HER3 and reduces HER2 phosphorylation. This work also includes preliminary efforts to characterize HER2-HER3 oligomers using single molecule photobleaching experiments. This work lays the groundwork for future studies involving EGFR family receptor regulation
Simple and efficient way of speeding up transmission calculations with $k$-point sampling
Creators: name: Falkenberg, Jesper Toft
name: Brandbyge, Mads
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The transmissions as functions of energy are central for electron or phonon transport in the Landauer transport picture. We suggest a simple and computationally "cheap" post-processing scheme to interpolate transmission functions over $k$-points to get smooth well-converged average transmission functions. This is relevant for data obtained using typical "expensive" first principles calculations where the leads/electrodes are described by periodic boundary conditions. We show examples of transport in graphene structures where a speed-up of an order of magnitude is easily obtained.
description: 6 pages, 4 figures
(101405) Katherine Mary Perry
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Leadership style as a factor in the radiographer’s motivation
Creators: name: Azevedo, Kevin
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Radiographers
subject: Professional issues
subject: CT
subject: Digital radiography
subject: Conventional radiography
subject: Physiological studies
subject: Health policy and practice
subject: Outcomes
subject: Quality assurance
subject: Patterns of Care

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Objective of this work is to establish whether the motivation of radiology technicians is related to the leadership style adopted by its leader...
Identification of clinically relevant dysglycemia phenotypes based on continuous glucose monitoring data from youth with type 1 diabetes and elevated hemoglobin A1c
Creators: name: Buse, J.B.
name: Aiello, A.E.
name: Nguyen, C.T.
name: Mayer-Davis, E.J.
name: Maahs, D.M.
name: Kosorok, M.R.
name: Kahkoska, A.R.
name: Crandell, J.
name: Adair, L.A.
name: Burger, K.S.
Publisher: name: Blackwell Publishing Ltd
Year: 2019

description: Background/Objective: To identify and characterize subgroups of adolescents with type 1 diabetes (T1D) and elevated hemoglobin A1c (HbA1c) who share patterns in their continuous glucose monitoring (CGM) data as “dysglycemia phenotypes.”. Methods: Data were analyzed from the Flexible Lifestyles Empowering Change randomized trial. Adolescents with T1D (13-16 years, duration >1 year) and HbA1c 8% to 13% (64-119 mmol/mol) wore blinded CGM at baseline for 7 days. Participants were clustered based on eight CGM metrics measuring hypoglycemia, hyperglycemia, and glycemic variability. Clusters were characterized by their baseline features and 18 months changes in HbA1c using adjusted mixed effects models. For comparison, participants were stratified by baseline HbA1c (≤/>9.0% [75 mmol/mol]). Results: The study sample included 234 adolescents (49.8% female, baseline age 14.8 ± 1.1 years, baseline T1D duration 6.4 ± 3.7 years, baseline HbA1c 9.6% ± 1.2%, [81 ± 13 mmol/mol]). Three Dysglycemia Clusters were identified with significant differences across all CGM metrics (P <.001). Dysglycemia Cluster 3 (n = 40, 17.1%) showed severe hypoglycemia and glycemic variability with moderate hyperglycemia and had a lower baseline HbA1c than Clusters 1 and 2 (P <.001). This cluster showed increases in HbA1c over 18 months (p-for-interaction = 0.006). No other baseline characteristics were associated with Dysglycemia Clusters. High HbA1c was associated with lower pump use, greater insulin doses, more frequent blood glucose monitoring, lower motivation, and lower adherence to diabetes self-management (all P <.05). Conclusions: There are subgroups of adolescents with T1D for which glycemic control is challenged by different aspects of dysglycemia. Enhanced understanding of demographic, behavioral, and clinical characteristics that contribute to CGM-derived dysglycemia phenotypes may reveal strategies to improve treatment.
(101398) William Maish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101400) Walter Machado Maish
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hydrodynamic correlations in shear flow: A Multiparticle--Collision--Dynamics simulation study
Creators: name: Varghese, Anoop
name: Huang, Chien-Cheng
name: Winkler, Roland G.
name: Gompper, Gerhard
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The nonequilibrium hydrodynamic correlations of a Multiparticle-Collision-Dynamics (MPC) fluid in shear flow are studied by analytical calculations and simulations. The Navier-Stokes equations for a MPC fluid are linearized about the shear flow and the hydrodynamic modes are evaluated as an expansion in the momentum vector. The shear-rate dependence and anisotropy of the transverse and longitudinal velocity correlations are analyzed. We demonstrate that hydrodynamic correlations in shear flow are anisotropic, specifically, the two transverse modes are no longer identical. In addition, our simulations reveal the directional dependence of the frequency and attenuation of the longitudinal velocity correlation function. Furthermore, the velocity autocorrelation functions of a tagged fluid particle in shear flow are determined. The simulations results for various hydrodynamic correlations agree very well with the theoretical predictions.
description: 8 pages, 5 figures
Advances in transdermal insulin delivery
Creators: name: Buse, J.B.
name: Wang, J.
name: Gu, Z.
name: Zhang, Y.
name: Yu, J.
name: Kahkoska, A.R.
Publisher: name: Elsevier B.V.
Year: 2019

description: Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Transdermal systems designed to prevent insulin degradation and offer controlled, sustained release of insulin may be desirable for patients and lead to increased adherence and glycemic outcomes. A challenge for transdermal insulin delivery is the inefficient passive insulin absorption through the skin due to the large molecular weight of the protein drug. In this review, we focus on the different transdermal insulin delivery techniques and their respective advantages and limitations, including chemical enhancers-promoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods.
Video Decoding Energy Estimation Using Processor Events
Creators: name: Herglotz, Christian
name: Kaup, André
Publisher: name: arXiv
Year: 2023
Subjects: subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we show that processor events like instruction counts or cache misses can be used to accurately estimate the processing energy of software video decoders. Therefore, we perform energy measurements on an ARM-based evaluation platform and count processor level events using a dedicated profiling software. Measurements are performed for various codecs and decoder implementations to prove the general viability of our observations. Using the estimation method proposed in this paper, the true decoding energy for various recent video coding standards including HEVC and VP9 can be estimated with a mean estimation error that is smaller than 6%.
description: 5 pages, 2 figures
title: Postoperative complications of surgically and/or endovascularly treated thoracic aorta.
Creators: name: Kotnik, Maruša
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Infection
subject: Haemorrhage
subject: Dissection
subject: Surgery
subject: Diagnostic procedure
subject: Complications
subject: MR-Angiography
subject: CT
subject: CT-Angiography
subject: Interventional vascular
subject: Cardiovascular system
subject: Arteries / Aorta

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To learn the different diseases of thoracic aorta that require surgical and/or endovascular intervention. To recognize various postoperative complications based on their abnormal radiologic appearances. To understand the diagnostic and treatment...
Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs
Creators: name: Khademhosseini, A.
name: Zhang, X.
name: Gu, Z.
name: Chen, G.
name: Qian, C.
name: Wang, J.
name: Chen, Z.
name: Kahkoska, A.R.
name: Yu, J.
name: Wang, Z.
name: Shen, Q.
name: Buse, J.B.
name: Sun, W.
name: Zhang, Y.
name: Cai, L.
Publisher: name: American Association for the Advancement of Science
Year: 2019

description: Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction. Both high insulin loading efficiency (95%) and loading capacity (49%) can be achieved. In the presence of a hyperglycemic state, the glucose-responsive phenylboronic acid (PBA) binds glucose instantly and converts the charge of the polymeric moiety from positive to negative, thereby enabling the release of insulin from the complex. Adjusting the ratio of the positively charged group to PBA achieves inhibited insulin release from the complex under normoglycemic conditions and promoted release under hyperglycemic conditions. Through chemically induced type 1 diabetic mouse and swine models, in vivo hyperglycemia-triggered insulin release with fast response is demonstrated after the complex is administrated by either subcutaneous injection or transdermal microneedle array patch.
STEMplus: Base para la educación del siglo XXI
Creators: name: Reiss, Kristina
name: Filtzinger, Barbara
Publisher: name: Universitaet Tuebingen
Year: 2023
Subjects: subject: MINT-Fächer
subject: Schulbildung
subject: Entdeckendes Lernen
subject: Kommunikation
subject: Kollaboration
subject: Kreativität
subject: Kritisches Denken

description: Den MINT-Fächern kommt in unserer zunehmend technologiebestimmten Welt eine besondere Rolle zu. Es gilt daher, Kinder und Jugendliche gerade im Schulunterricht gezielt in die Grundlagen einzuführen. Dabei darf es allerdings nicht nur um deklaratives Wissen, um Begriffe und ab-fragbare Fakten gehen. Vielmehr ist es wichtig, ihre Motivation und ihr Interesse zu wecken, sie über das eigene Handeln Wissenschaft erfahren zu lassen, sie zu eigenen Experimenten, zum kritischen Hinterfragen und zur Diskussion der Ergebnisse anzuregen. Genauso sind die MINT-Fächer in ihrer gesellschaftlichen Rolle zu sehen, die mit einer besonderen Verantwortung im Hinblick auf die Konsequenzen des Handelns verbunden ist. Auch hier müssen Kinder und Jugendliche Erfahrungen machen können, die sie auf eine Teilhabe an der Gesellschaft vorbe-reiten. Dazu gehört es dann, offen für kreative Wege auch außerhalb der eigenen Umgebung zu sein, diverse Aspekte von Wissen zu prüfen und unterschiedliche Kulturen zu respektieren. Es reicht entsprechend nicht, bei den fachbezogenen Aspekten von MINT stehen zu bleiben. Vielmehr braucht es einen ganzheitlichen Ansatz und dieser verbirgt sich hinter dem Kürzel MINTplus.
description: Der inhaltsgleiche Artikel ist in diesem Portal MINTplus STEMplus auch in den Sprachen Deutsch und Englisch verfügbar.
description: Las asignaturas STEM tienen un papel especial que desempeñar en nuestro mundo, cada vez más impulsado por la tecnología. Por lo tanto, es importante introducir a niñas, niños y jóvenes en los conceptos básicos de forma selectiva, especialmente en las clases de aula escolar. Sin embargo, no debe tratarse sólo de conocimientos declarativos, conceptos y hechos que puedan ponerse a prueba. Es mucho más importante despertar su motivación e interés, dejarles experimentar la ciencia a través de sus propias acciones, animarles a realizar sus propios experimentos, a cues- tionar los resultados críticamente y a discutirlos. Del mismo modo, las asignaturas STEM deben considerarse en su papel social, que está relacionado con una responsabilidad especial respecto a las consecuencias de las acciones. También en este caso, las niñas, los niños y los jóvenes deben poder vivir experiencias que les preparen para participar en la sociedad. Esto incluye estar abierto a formas creativas también fuera de su propio entorno, examinar diversos aspectos del cono- cimiento y respetar culturas diferentes. En consecuencia, no basta con detenerse en los aspectos de STEM relacionados con las asignaturas. Más bien se necesita un enfoque holístico, y esto es lo que se esconde tras el acrónimo “STEMplus”.
STEMplus: The Foundation of an Education in the 21st Century
Creators: name: Reiss, Kristina
name: Filtzinger, Barbara
Publisher: name: Universitaet Tuebingen
Year: 2023
Subjects: subject: MINT-Fächer
subject: Schulbildung
subject: Entdeckendes Lernen
subject: Kommunikation
subject: Kollaboration
subject: Kreativität

description: Den MINT-Fächern kommt in unserer zunehmend technologiebestimmten Welt eine besondere Rolle zu. Es gilt daher, Kinder und Jugendliche gerade im Schulunterricht gezielt in die Grundlagen einzuführen. Dabei darf es allerdings nicht nur um deklaratives Wissen, um Begriffe und ab-fragbare Fakten gehen. Vielmehr ist es wichtig, ihre Motivation und ihr Interesse zu wecken, sie über das eigene Handeln Wissenschaft erfahren zu lassen, sie zu eigenen Experimenten, zum kritischen Hinterfragen und zur Diskussion der Ergebnisse anzuregen. Genauso sind die MINT-Fächer in ihrer gesellschaftlichen Rolle zu sehen, die mit einer besonderen Verantwortung im Hinblick auf die Konsequenzen des Handelns verbunden ist. Auch hier müssen Kinder und Jugendliche Erfahrungen machen können, die sie auf eine Teilhabe an der Gesellschaft vorbe-reiten. Dazu gehört es dann, offen für kreative Wege auch außerhalb der eigenen Umgebung zu sein, diverse Aspekte von Wissen zu prüfen und unterschiedliche Kulturen zu respektieren. Es reicht entsprechend nicht, bei den fachbezogenen Aspekten von MINT stehen zu bleiben. Vielmehr braucht es einen ganzheitlichen Ansatz und dieser verbirgt sich hinter dem Kürzel MINTplus.
description: Der inhaltsgleiche Artikel ist in diesem Portal MINTplus STEMplus auch in den Sprachen Spanisch und Deutsch verfügbar.
description: The STEM subjects have a special role to play in our increasingly technology-driven world. That is why it is important to introduce children and adolescents to the basics in a targeted way, especially in school lessons. However, this should not only be about declarative knowledge, about testable terms and facts. Rather, it is important to stimulate their motivation and interest, to let them experience science through their own actions, and to encourage them to conduct their own experiments, to question them critically, and to discuss the results. Likewise, STEM subjects must be seen in terms of their role in the society, which comes with a special respon- sibility in terms of the consequences of actions. Here, too, children and adolescents must be able to have experiences that prepare them for participation in society. This includes being open to creative ways outside their own environment, engaging with different aspects of knowledge and respecting other cultures. Thus, it is not enough to limit oneself to the technical aspects of STEM. Rather, a holistic approach is required, which is what is at the bottom of the acronym STEMplus.