cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM1 of Engineering Corynebacterium glutamicum to produce 5-aminolevulinic acid from glucose
Creators: name: Xiaoli Yu
name: Haiying Jin
name: Wenjing Liu
name: Wang, Qian
name: Qingsheng Qi
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1. Figure S1. Multiple-sequence alignment of GluRS (A), HemA (B), and HemL (C) from E. coli and C. glutamicum. Table S1. Strains and plasmids used in this study. Table S2. Primers used in this study. Table S3. Down-regulated genes (-) and up-regulated genes (+) were identified using comparative transcriptome analysis of the C. glutamicum strains SEAL and PECX.
Hyalochiton colpochilus
Creators: name: Heiss, Ernst
name: Eckelt, Andreas
name: Lederwasch, Manfred
name: Unterasinger, Romed
name: T, Familie
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Tingidae
Hyalochiton
Hyalochiton colpochilus

description: Hyalochiton colpochilus (HORVÁTH, 1897)
E S P S p a n i e n: Andalusien, Pico Veleta, 1 Ex., 25. VII. 1959, leg. fA.
F R A F r a n k r e i c h: Languedoc-Roussillon, St.Guilhem leDesert, 2Ex., 18. VI. 1976, leg. Péricart J.; Languedoc-Roussillon, Banyuls W / Massane, 2 Ex., 26. VII. 1956, leg. Weber.
description: Published as part of Heiss, Ernst, Eckelt, Andreas, Lederwasch, Manfred, Unterasinger, Romed & T, Familie, 2022, Die Heteropterensammlung Ernst Heiss im Tiroler Landesmuseum Ferdinandeum. Teil V: Tingoidea, Familie Tingidae LAPORTE, 1832, pp. 85-142 in Linzer biologische Beiträge 54 (1) on page 110, DOI: 10.5281/zenodo.7507194
Additional file 7: of Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom
Creators: name: Sussex, Jon
name: Feng, Yan
name: Mestre-Ferrandiz, Jorge
name: Pistollato, Michele
name: Hafner, Marco
name: Burridge, Peter
name: Grant, Jonathan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Modelling specification tables. (DOCX 21 kb)
The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure
Creators: name: Mustroph, Julian
name: Drzymalski, Marzena
name: Baier, Maria
name: Pabel, Steffen
name: Biedermann, Alexander
name: Memmel, Bernadette
name: Durczok, Melanie
name: Neef, Stefan
name: Sag, Can Martin
name: Floerchinger, Bernhard
name: Rupprecht, Leopold
name: Schmid, Christof
name: Zausig, York
name: Bégis, Guillaume
name: Briand, Veronique
name: Ozoux, Marie‐Laure
name: Tamarelle, Dorothee
name: Ballet, Veronique
name: Janiak, Philip
name: Beauverger, Philippe
name: Maier, Lars S.
name: Wagner, Stefan
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: RETICULUM CA2+ LEAK; DILATED CARDIOMYOPATHY; CAMKII; POTENTIATION; HYPERTROPHY; DYSFUNCTION; MYOCARDIUM; STRESS; MODEL; LOAD; Inhibition; Heart failure; Contractility; SR Ca leak; Arrhythmias
subject: 610 Medizin

description: Aims Excessive activation of Ca/calmodulin-dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We investigated a novel CaMKII delta/CaMKII-selective, ATP-competitive, orally available CaMKII inhibitor (RA608) on right atrial biopsies of 119 patients undergoing heart surgery. Furthermore, we evaluated its oral efficacy to prevent deterioration of HF in mice after transverse aortic constriction (TAC). Methods and results In human atrial cardiomyocytes and trabeculae, respectively, RA608 significantly reduced sarcoplasmic reticulum Ca leak, reduced diastolic tension, and increased sarcoplasmic reticulum Ca content. Patch-clamp recordings confirmed the safety of RA608 in human cardiomyocytes. C57BL6/J mice were subjected to TAC, and left ventricular function was monitored by echocardiography. Two weeks after TAC, RA608 was administered by oral gavage for 7 days. Oral RA608 treatment prevented deterioration of ejection fraction. At 3 weeks after TAC, ejection fraction was 46.1 +/- 3.7% (RA608) vs. 34.9 +/- 2.6% (vehicle), n = 9 vs.n = 12, P < 0.05, ANOVA, which correlated with significantly less CaMKII autophosphorylation at threonine 287. Moreover, a single oral dose significantly reduced inducibility of atrial and ventricular arrhythmias in CaMKII delta transgenic mice 4 h after administration. Atrial fibrillation was induced in 6/6 mice for vehicle vs. 1/7 for RA608,P < 0.05, 'n - 1' chi(2) test. Ventricular tachycardia was induced in 6/7 for vehicle vs. 2/7 for RA608,P < 0.05, 'n - 1' chi(2) test. Conclusions RA608 is the first orally administrable CaMKII inhibitor with potent efficacy in human myocytes. Moreover, oral administration potently inhibits arrhythmogenesis and attenuates HF development in micein vivo.
Additional file 5: of Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom
Creators: name: Sussex, Jon
name: Feng, Yan
name: Mestre-Ferrandiz, Jorge
name: Pistollato, Michele
name: Hafner, Marco
name: Burridge, Peter
name: Grant, Jonathan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Interview protocol for key informants. (DOCX 15 kb)
Weak and Unstable Prediction of Personality from the Structural Connectome
Creators: name: Rauland, Amelie
name: Jung, Kyesam
name: Satterthwaite, Theodore D.
name: Cieslak, Matthew
name: Reetz, Kathrin
name: Eickhoff, Simon B.
name: Popovych, Oleksandr
Publisher: name: Forschungzentrum Jülich
Year: 2025
Subjects: subject: 050

description: Imaging neuroscience (2025). doi:10.1162/imag_a_00416
description: Personality neuroscience aims to discover links between personality traits and features of the brain. Previous neuroimaging studies have investigated the connection between the brain structure, microstructural properties of brain tissue or the functional connectivity (FC) and these personality traits. Analyses relating personality to diffusion weighted MRI measures were limited to investigating the voxel-wise or tract-wise association of microstructural properties with trait scores. The main goal of our study was to determine whether there is an individual predictive relationship between the structural connectome (SC) and the big five personality traits. To that end we expanded past work in two ways: First, by focusing on the entire structural connectome (SC) instead of separate voxels and tracts; and second, by predicting personality trait scores instead of performing a statistical correlation analysis to assess an out-of-sample performance. Prediction of personality from the SC is however not yet as established as prediction of behavior from the FC, and sparse studies in this field so far delivered rather heterogeneous results. We therefore further dedicated our study to investigate if and how different pipeline settings influence prediction performance. In a sample of 426 unrelated subjects with high quality MRI acquisitions from the Human Connectome Project, we analyzed 19 different brain parcellations, three SC weightings, three groups of subjects and four feature classes for the prediction of the five personality traits using a ridge regression. From the large number of evaluated pipelines, only very few lead to promising results of prediction accuracy r > 0.2, while the vast majority lead to a small prediction accuracy centered around zero. A markedly better prediction was observed for a cognition target confirming the chosen methods for SC calculation and prediction and indicating limitations of the personality trait scores and their relation to the SC. We therefore report, that for methods evaluated here, the SC cannot predict personality trait scores. Overall, we found that all considered pipeline conditions influence the predictive performance of both cognition and personality trait scores. The strongest differences were found for the trait openness and the SC weighting by number of streamlines which outperformed the other traits and weightings respectively. As there is a substantial variation in prediction accuracy across pipelines even for the same subjects and the same target, these findings highlight the crucial importance of pipeline settings for predicting individual traits from the SC.
description: Published by MIT Press, Cambridge, MA
Low long-term mortality in patients with sleep apnoea and positive airway pressure therapy: analysis of a large German healthcare database
Creators: name: Arzt, Michael
name: Woehrle, H.
name: Schoebel, C.
name: Oldenburg, O.
name: Young, P.
name: Fietze, I.
name: Ficker, J. H.
name: Bischoff-Everding, C.
name: Libutzki, B.
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: Sleep-disordered breathing, Treatment, Hospitalisation, Prognosis
subject: 610 Medizin

description: Background
There are limited data on long-term mortality in sleep apnoea (SA) patients with and without positive airway pressure (PAP) therapy. This retrospective cohort study investigated long-term hospitalisation and mortality rates in SA patients from a German statutory health insurance (SHI) database who did versus did not receive PAP therapy.

Methods
Patients had continuous insurance coverage from 01 January 2008 to 31 December 2013, complete medical records and ≥1 SA-related diagnosis in 2009. Those receiving PAP were matched with a control group not treated with PAP. Outcomes (hospitalisations including stays in the sleep laboratory) were compared between groups the year prior to and the 4 years after SA diagnosis. Mortality was assessed in the 4 years after SA diagnosis.

Results
2176 PAP therapy recipients were matched with 2176 controls. The PAP group had a higher rate of hospitalisation in the year before SA diagnosis than the control group (80.2% vs. 26.6%; p = 0.0016). After diagnosis, the PAP group had a higher hospitalisation rate only in year 1 (p < 0.05), and average length of stay per hospitalisation was lower in the PAP group (p < 0.05 vs. control at years 1, 2 and 4). Cumulative all-cause mortality after year 3 (3.4% vs. 4.6%; p = 0.0287) and after year 4 (4.8% vs. 6.5%; p = 0.0175) was significantly lower in SA patients receiving PAP versus controls (relative risk reduction for death after 4 years: 25.5%).

Conclusion
This real-world cohort study showed an association between long-term PAP therapy use and lower mortality, a higher rate of hospitalisations before and shorter hospital stays after treatment initiation.
title:  SEX DIFFERENCES IN PEDIATRIC HYPERTENSION
title: OBESITY, STRESS, AND THE RENIN-ANGIOTENSIN SYSTEM
titleType: Subtitle
Creators: name: Dyar, Allyson
Publisher: name: University of Kentucky Libraries
Year: 2024
Subjects: classificationCode: 4.5
subject: FOS: Other agricultural sciences

description: Pediatric hypertension, linked to long-term cardiovascular risks, shows increasing prevalence and varying patterns between boys and girls. This study explores sex-based differences in hypertension among 251 children aged 6-18 from Kentucky Children’s Hospital. Using 24-hour ambulatory blood pressure monitoring (ABPM) and assessing plasma renin, aldosterone, and cortisol, we examined blood pressure severity by sex. Girls showed a higher incidence of severe hypertension and elevated cortisol levels, whereas boys had higher mean systolic blood pressure. Aldosterone was associated with night systolic blood pressure in girls, while night diastolic blood pressure was linked to aldosterone in both sexes and renin in girls. Tests of between-subject effects revealed that cortisol, BMI, and age influenced blood pressure differently across sexes. These results suggest unique physiological mechanisms in boys and girls, emphasizing the need for sex-specific diagnostic criteria and interventions. Tailored approaches to pediatric hypertension may improve early detection and mitigate adult cardiovascular risks.
Hyalochiton komaroffii
Creators: name: Heiss, Ernst
name: Eckelt, Andreas
name: Lederwasch, Manfred
name: Unterasinger, Romed
name: T, Familie
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Tingidae
Hyalochiton
Hyalochiton komaroffii

description: Hyalochiton komaroffii (JAKOVLEV, 1880)
B G R B u l g a r i e n: Blagoevgrad, Kresna Schlucht, 3 Ex., 20. VI. 1969, leg. Josifov M.
E S P S p a n i e n: Katalonien, Castelldefels, 6 Ex., 28. IX. 1962, leg. Weber.
F R A F r a n k r e i c h: Provence-Alpes-Cote d'Azur, Digne, 5 Ex., 9. VII. 1956, leg. Weber; Provence-Alpes-Côte d'Azur, Digne / Champ de Bes, 3 Ex., 22. VII. 1955, leg. Eckerlein H.
description: Published as part of Heiss, Ernst, Eckelt, Andreas, Lederwasch, Manfred, Unterasinger, Romed & T, Familie, 2022, Die Heteropterensammlung Ernst Heiss im Tiroler Landesmuseum Ferdinandeum. Teil V: Tingoidea, Familie Tingidae LAPORTE, 1832, pp. 85-142 in Linzer biologische Beiträge 54 (1) on page 110, DOI: 10.5281/zenodo.7507194
Tomocerus ocreatus Denis 1948
Creators: name: Gong, Xin
name: Qin, Chunyan
name: Yu, Daoyuan
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Tomoceridae
Tomocerus
Tomocerus ocreatus

description: Key to species with single large dental spine in T. ocreatus group
1. Body colour grey; anterior area of head with 2, 0 macrochaetae; cave-dwelling species........ T. leyensis Yu & Deharveng
- Body colour yellow; anterior area of head with 2, 4 macrochaetae; surface-dwelling species.......................... 2
2. Antennae subequal to body in length, being 0.9–1.0× length of body; manubrium with 1+1 blunt dorsal chaetae.............................................................................................. T. paraspinulus sp. nov.
- Antennae shorter than body, being 0.6–0.75× length of body; manubrium without blunt dorsal chaetae.................. 3
3. Dens basally with blunt chaeta; denticles on dental spines unevenly distributed................. T. pseudospinulus sp. nov.
- Dens basally without blunt chaeta; denticles on dental spines evenly distributed........... T. spinulus Chen & Christiansen
description: Published as part of Gong, Xin, Qin, Chunyan & Yu, Daoyuan, 2018, Two new species of Tomocerus ocreatus group with a single large distal dental spine (Collembola, Tomoceridae), pp. 273-282 in Zootaxa 4514 (2) on page 281, DOI: 10.11646/zootaxa.4514.2.10, http://zenodo.org/record/2607838
Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease—results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health
Creators: name: Wolff, Daniel
name: Herzberg, Philipp Y.
name: Herrmann, Anne
name: Pavletic, Steven Z.
name: Heussner, Pia
name: Mumm, Friederike
name: Höfer, Christina
name: Hilgendorf, Inken
name: Hemmati, Philipp G.
name: Holler, Ernst
name: Greinix, Hildegard
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: HEMATOPOIETIC-CELL TRANSPLANTATION; LONG-TERM SURVIVORS; BONE-MARROW-TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; COMORBIDITY INDEX; CLINICAL-PRACTICE; ALLOGENEIC TRANSPLANTATION; INTERNATIONAL-BLOOD; FUNCTIONAL STATUS; APLASTIC-ANEMIA;
subject: 610 Medizin

description: Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Post-transplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL within a multicenter trial, including 208 patients (pts) after alloHSCT, who were prospectively evaluated applying the FACT-BMT, the Human Activity Profile (HAP), the SF-36 v.2, PTMI and the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI). The most prevalent comorbidities were compensated arterial hypertension (28.4%), ambulatory infections (25.5%), iron overload (23%), mild renal function impairment (20%), and osteoporosis (13%). Applying the PTMI 13% of patients had no comorbidity, while 37.1% had 1-3 comorbidities, 27.4% had 4-6 comorbidities, and 13.5% had > 6 comorbidities. Chronic graft-versus-host disease (cGvHD) was significantly associated with the PTMI, while age and prior acute GvHD were not. In contrast, the HCT-CI was not associated with the presence of cGvHD. cGvHD was significantly associated with depression (r = 0.16), neurological disease (r = 0.21), osteoporosis (r = 0.18) and nonmelanoma skin cancer (r = 0.26). The PTMI demonstrated strong measurement properties and compared to the HCT-CI captured a wider range of comorbidities associated with cGvHD.
Additional file 4: of Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom
Creators: name: Sussex, Jon
name: Feng, Yan
name: Mestre-Ferrandiz, Jorge
name: Pistollato, Michele
name: Hafner, Marco
name: Burridge, Peter
name: Grant, Jonathan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Literature review of the drivers of private pharmaceutical R&D. (DOCX 33 kb)
Aspek Keamanan Open Journal System
Creators: name: Saputra, Dwi Fajar
Publisher: name: Zenodo
Year: 2024

description: Dipresentasikan oleh Dwi Fajar S, S.Sos., M.M. di Webinar "Aspek Keamanan Open Journal System" pada Kamis, 19 Desember 2024 melalui Zoom Relawan Jurnal Indonesia
Hyalochiton multiseriatus
Creators: name: Heiss, Ernst
name: Eckelt, Andreas
name: Lederwasch, Manfred
name: Unterasinger, Romed
name: T, Familie
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Tingidae
Hyalochiton
Hyalochiton multiseriatus

description: Hyalochiton multiseriatus (REUTER, 1888)
I R Q I r a k: Dohuk, Duhok, 2 Ex., 16. VI. 1958, leg. Remane R. T U R T ü r k e i: Konya, Akschehir, 1 Ex., 1. VI. 1955, leg. Seidenstücker; Nigde, Ciftehan, 1 Ex., 27. V. 1955, leg. Seidenstücker.
description: Published as part of Heiss, Ernst, Eckelt, Andreas, Lederwasch, Manfred, Unterasinger, Romed & T, Familie, 2022, Die Heteropterensammlung Ernst Heiss im Tiroler Landesmuseum Ferdinandeum. Teil V: Tingoidea, Familie Tingidae LAPORTE, 1832, pp. 85-142 in Linzer biologische Beiträge 54 (1) on page 110, DOI: 10.5281/zenodo.7507194
Καταγραφή της στοματικής υγείας και του οδοντιατρικού φόβου των παιδιών Ρομά στην περιφέρεια Θεσσαλονίκης
Creators: name: Ζαρκάδη, Αθανασία Ειρήνη Πέτρου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Στοματική Υγεία
Οδοντιατρικός Φόβος
Ρομά
Oral Health
Dental Fear
Roma

description: Σκοπός: Η τεκμηρίωση της κατάστασης της τερηδόνας, του επιπέδου φόβου και η αξιολόγηση της στοματικής υγιεινής και της περιοδοντικής υγείας παιδιών Ρομά στη Θεσσαλονίκη-Ελλάδα, καθώς και η διερεύνηση συσχετίσεων με οδοντιατρική συμπεριφορά και αντιλήψεις. Μέθοδοι: Εξετάστηκαν όλα τα παιδιά Ρομά που φοιτούσαν σε δημοτικά σχολεία σε καθορισμένη περιοχή της κοινότητας Ρομά της Θεσσαλονίκης (n=135). Η στοματική υγιεινή αξιολογήθηκε χρησιμοποιώντας δείκτες DI-S και CI-S, η περιοδοντική υγεία με τον δείκτη CPI, η κατάσταση της τερηδόνας με τα κριτήρια ICDAS II και ο οδοντιατρικός φόβος με το CFSS-DS. Τα ερωτηματολόγια αξιολόγησαν την οδοντιατρική συμπεριφορά και αντιλήψεις. Αποτελέσματα: Το 3,7% των ατόμων βρέθηκε ελεύθερο τερηδόνας, ενώ το 83,0% χρειαζόταν αποκαταστατική θεραπεία. Τρυγία βρέθηκε στο 54,1% των ατόμων και το 33% παρουσίασε αιμορραγία. Ένα σημαντικό 51,9% δεν έχει επισκεφθεί ποτέ οδοντίατρο και το 40,7% αναζητά οδοντιατρική φροντίδα μόνο σε επείγοντα περιστατικά. Παρά το γεγονός ότι περισσότεροι από τους μισούς (51,1%) εξέφρασαν δυσαρέσκεια με την οδοντική τους υγιεινή, το 41,5% ανέφερε ότι σχεδόν ποτέ δεν βουρτσίζει, μόνο το 3% δήλωσε πως χρησιμοποιεί οδοντικό νήμα και το 4,4% στοματικό διάλυμα με φθόριο. Επιπλέον, το 10,3% των συμμετεχόντων ανέφερε ότι κάπνιζε και το 8,9% παραδέχτηκε την κατανάλωση αλκοόλ. Ο οδοντιατρικός φόβος βρέθηκε 31,4 ± 10,2. Συμπέρασμα: Τα ευρήματα υποδεικνύουν την ανάγκη ενίσχυσης της ευαισθητοποίησης των παιδιών Ρομά στη στοματική υγεία και της πρόσβασης στην οδοντιατρική περίθαλψη.
description: Aim: The documentation of caries status, level of fear and the assessment of oral hygiene and periodontal health of Roma children in Thessaloniki-Greece, as well as the exploration of correlations with dental behavior and perceptions. Methods: All Roma children attending primary schools in a designated Roma community area of Thessaloniki were examined (n=135). Oral hygiene was evaluated using DI-S and CI-S indices, periodontal health with the CPI index, dental caries status with ICDAS II criteria and dental fear with CFSS-DS. Questionnaires assessed dental behavior and perceptions. Results: 3.7% of individuals were caries-free, whereas 83.0% required restorative treatment. Calculus was found in 54.1% of subjects, and 33% presented with bleeding. A significant 51.9% have never visited a dentist and 40.7% only seek dental care only in emergencies. Despite over half (51.1%) expressing dissatisfaction with their dental hygiene, 41.5% reported they almost never brush, 3% used dental floss, and 4.4% used fluoride mouthwash. Furthermore, 10.3% of the subjects reported smoking and 8.9% admitted to alcohol consumption. Dental fear was found 31.4 ± 10.2 Conclusion: The findings indicate the need to enhance Roma children’s oral health awareness and access to dental care.
Hyalochiton syrmiensis
Creators: name: Heiss, Ernst
name: Eckelt, Andreas
name: Lederwasch, Manfred
name: Unterasinger, Romed
name: T, Familie
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Tingidae
Hyalochiton
Hyalochiton syrmiensis

description: Hyalochiton syrmiensis (HORVÁTH, 1897)
F R A F r a n k r e i c h: Languedoc-Roussillon, Banyuls W/ Massane, 23 Ex., 26. VII. 1956, leg. Weber.
description: Published as part of Heiss, Ernst, Eckelt, Andreas, Lederwasch, Manfred, Unterasinger, Romed & T, Familie, 2022, Die Heteropterensammlung Ernst Heiss im Tiroler Landesmuseum Ferdinandeum. Teil V: Tingoidea, Familie Tingidae LAPORTE, 1832, pp. 85-142 in Linzer biologische Beiträge 54 (1) on page 111, DOI: 10.5281/zenodo.7507194
The impact of strategic network on corporate strategic decisions: evidence from China
Creators: name: Chen, Tao
Publisher: name: University of Surrey
Year: 2024
Subjects: Political connections
Military connections
Innovation
Internationalization
Cross-Board Merger and Acquisition
State ownership
Human resource slack
Family ownership
Financial slack

description: This thesis investigates the impact of strategic networks on corporate strategic decision-making, focusing on how political and military connections influence firm innovation and internationalization based on data from Chinese listed firms from 2006 to 2017. It utilizes robust analytical methods to offer solid contributions to literature and practice. The first study demonstrates that political connections facilitate innovation in emerging markets by enabling firms to continue to acquire necessary resources and establish partnerships, with human resource slack and state ownership playing crucial roles in the innovation process. The second study addresses how political connections, financial slack, and state ownership interact to affect cross-border mergers and acquisitions, suggesting that while political connections may increase transaction costs, financial slack and state ownership can mitigate these effects. The third paper applies prospect theory to explore the risk-taking behaviors of executives with military backgrounds in domestic innovation and overseas expansion, considering the influence of non-financial wealth and the unique context of family firms. The findings reveal varied risk preferences influenced by military connections and the firm's ownership structure, contributing new perspectives to the understanding of strategic networks.
Alterations of the renin angiotensin system in human end-stage heart failure before and after mechanical cardiac unloading by LVAD support
Creators: name: Birner, Christoph
name: Messmann, Rebecca
name: Dietl, Alexander
name: Wagner, Stefan
name: Domenig, Oliver
name: Jungbauer, Carsten
name: Luchner, Andreas
name: Maier, Lars S.
name: Schopka, Simon
name: Hirt, Stephan
name: Schmid, Christof
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: ASSIST DEVICE SUPPORT; DESTINATION THERAPY; CIRCULATORY SUPPORT; GENE-EXPRESSION; II RECEPTOR; MYOCARDIUM; HYPERTROPHY; INHIBITION; REGRESSION; PULSATILE; Heart failure; LVAD; Renin angiotensin system
subject: 610 Medizin

description: Heart transplantation is often an unrealizable therapeutic option for end-stage heart failure, which is why mechanical left ventricular assist devices (LVADs) become an increasingly important therapeutic alternative. Currently, there is a lack of information about molecular mechanisms which are influenced by LVADs, particularly regarding the pathophysiologically critical renin angiotensin system (RAS). We, therefore, determined regulation patterns of key components of the RAS and the beta-arrestin signaling pathways in left ventricular (LV) tissue specimens from 8 patients with end-stage ischemic cardiomyopathy (ICM) and 12 patients with terminal dilated cardiomyopathy (DCM) before and after LVAD implantation and compared them with non-failing (NF) left ventricular tissue samples: AT1R, AT2R, ACE, ACE2, MasR, and ADAM17 were analyzed by polymerase chain reaction. ERK, phosphorylated ERK, p38, phosphorylated p38, JNK, phosphorylated JNK, GRK2, beta-arrestin 2, PI3K, Akt, and phosphorylated Akt were determined by Western blot analysis. Angiotensin I and Angiotensin II were quantified by mass spectrometry. Patients were predominantly middle-aged (53 +/- 10 years) men with severely impaired LV function (LVEF 19 +/- 8%), when receiving LVAD therapy for a mean duration of 331 +/- 317 days. Baseline characteristics did not differ significantly between ICM and DCM patients. By comparing failing with non-failing left ventricles, i.e., before LVAD implantation, a downregulation of AT1R, AT2R, and MasR and an upregulation of ACE, ACE2, GRK, beta-arrestin, ERK, PI3K, and Akt were seen. Following LVAD support, then angiotensin I, ACE2, GRK, and beta-arrestin were downregulated and AT2R, JNK, and p38 were upregulated. ACE, angiotensin II, AT1R, ADAM17, MasR, ERK, PI3K, and Akt remained unchanged. Some regulation patterns were influenced by the underlying etiology of heart failure, the severity of LV dysfunction at baseline, and the duration of LVAD therapy. Key components of the RAS and beta-arrestin signaling pathways were divergently altered in failing left ventricles both before and after LVAD implantation, whereas a remarkable fraction remained unchanged. This indicates a rather incomplete molecular reverse remodeling, whose functional relevance has to be further evaluated.
Additional file 1: of Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry
Creators: name: Wanqing Wen
name: Xiao-Ou Shu
name: Xingyi Guo
name: Qiuyin Cai
name: Jirong Long
name: Bolla, Manjeet
name: Michailidou, Kyriaki
name: Dennis, Joe
name: Wang, Qin
name: Yu-Tang Gao
name: Zheng, Ying
name: Dunning, Alison
name: GarcĂ­A-Closas, Montserrat
name: Brennan, Paul
name: Shou-Tung Chen
name: Ji-Yeob Choi
name: Hartman, Mikael
name: Ito, Hidemi
name: Artitaya Lophatananon
name: Keitaro Matsuo
name: Miao, Hui
name: Muir, Kenneth
name: Suleeporn Sangrajrang
name: Shen, Chen-Yang
name: Teo, Soo
name: Chiu-Chen Tseng
name: Wu, Anna
name: Yip, Cheng
name: Simard, Jacques
name: Pharoah, Paul
name: Hall, Per
name: Daehee Kang
name: Yongbing Xiang
name: Easton, Douglas
name: Zheng, Wei
Publisher: name: Figshare
Year: 2016
Subjects: subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: is Table S1 presenting participating studies in this analysis. (PDF 79 kb)
Trends and cardiovascular outcomes of Takotsubo syndrome with cardiogenic shock vs. mixed cardiogenic and septic shock: a nationwide propensity matched analysis
Creators: name: Fakhra, Sadaf
name: Faisaluddin, Mohammed
name: Sattar, Yasar
name: DeCicco, Danielle
name: Ahmed, Asmaa
name: Patel, Neel
name: Balasubramanian, Senthil
name: Ludhwani, Dipesh
name: Masood, Hassan
name: Raina, Sameer
name: Gonuguntla, Karthik
name: Feitell, Scott C.
name: Tarun, Tushar
name: Balla, Sudarshan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Mental Health

description: Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy, can be complicated by shock. The outcomes of patients with TTS complicated with cardiogenic shock (CS) versus mixed cardiogenic and septic shock (MS) is not known. We queried Nationwide Inpatient Sample (NIS) from 2009–2020 to compare TTS patients with CS and MS using International Classification of Disease, Ninth & Tenth Edition, Clinical Modification (ICD- 9 & 10-CM) coding. In-hospital outcomes were compared using one: one propensity score matched (PSM) analysis. The primary outcome was in-hospital mortality. Of 23,126 patients with TTS 17,132 (74%) had CS, and 6,269 (26%) had MS. The mean age was 67 years in CS and 66 years in MS, and majority of patients were female (n = 17,775, 77%). On adjusted multivariate analysis, MS patients had higher odds of in-hospital mortality (aOR 1.44, 95% CI 1.36–1.52), AKI (aOR 1.53, 95% CI 1.48–1.58), pressor requirement (aOR 1.37, 95% CI 1.25–1.50). However, had lower odds of MCS use (aOR 0.44, 95% CI 0.40–0.48) and cardiac arrest (aOR: 0.81, 95% CI 0.73–0.90) (p-value <0.0001). Mean LOS and inflation-adjusted hospital charges were higher in MS. MS in the setting of TTS have higher rates of in-hospital mortality, AKI, and pressor requirements.
Indocader loebli PERICART 1981
Creators: name: Heiss, Ernst
name: Eckelt, Andreas
name: Lederwasch, Manfred
name: Unterasinger, Romed
name: T, Familie
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Tingidae
Indocader
Indocader loebli

description: Indocader loebli PÉRICART, 1981 exld
I N D I n d i e n: Westbengalen, Darjeeling/ Ghoom, 1 Ex., 15. X. 1978, leg. Besuchet & Löbl (Paratype).
description: Published as part of Heiss, Ernst, Eckelt, Andreas, Lederwasch, Manfred, Unterasinger, Romed & T, Familie, 2022, Die Heteropterensammlung Ernst Heiss im Tiroler Landesmuseum Ferdinandeum. Teil V: Tingoidea, Familie Tingidae LAPORTE, 1832, pp. 85-142 in Linzer biologische Beiträge 54 (1) on page 111, DOI: 10.5281/zenodo.7507194
Additional file 3: of Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry
Creators: name: Wanqing Wen
name: Xiao-Ou Shu
name: Xingyi Guo
name: Qiuyin Cai
name: Jirong Long
name: Bolla, Manjeet
name: Michailidou, Kyriaki
name: Dennis, Joe
name: Wang, Qin
name: Yu-Tang Gao
name: Zheng, Ying
name: Dunning, Alison
name: GarcĂ­A-Closas, Montserrat
name: Brennan, Paul
name: Shou-Tung Chen
name: Ji-Yeob Choi
name: Hartman, Mikael
name: Ito, Hidemi
name: Artitaya Lophatananon
name: Keitaro Matsuo
name: Miao, Hui
name: Muir, Kenneth
name: Suleeporn Sangrajrang
name: Shen, Chen-Yang
name: Teo, Soo
name: Chiu-Chen Tseng
name: Wu, Anna
name: Yip, Cheng
name: Simard, Jacques
name: Pharoah, Paul
name: Hall, Per
name: Daehee Kang
name: Yongbing Xiang
name: Easton, Douglas
name: Zheng, Wei
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: is Table S3 presenting the association between selected SNPs and ER-positive breast cancer risk in East Asian women. (PDF 134 kb)
Additional file 1: Table S1. of An iNTT system for the large-scale screening of differentially expressed, nuclear-targeted proteins: cold-treatment-induced nucleoproteins in Rye (Secale cereale L.)
Creators: name: Xinyou Cao
name: Xueyan Chen
name: Yangna Liu
name: Zhaoshi Xu
name: Liancheng Li
name: Yongbin Zhou
name: Jianjun Liu
name: Zhendong Zhao
name: Chen, Ming
name: Youzhi Ma
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: Related Unigenes using nuclear transportation trap (NTT) system and “after suppression subtractive” method. Table S2. Remove Unigenes using “after suppression subtractive” method from two libraries. Table S3. PCR primers for Q-RT-PCR analysis of gene expression. (DOC 327 kb)
Additional file 2: Figure S1. of An iNTT system for the large-scale screening of differentially expressed, nuclear-targeted proteins: cold-treatment-induced nucleoproteins in Rye (Secale cereale L.)
Creators: name: Xinyou Cao
name: Xueyan Chen
name: Yangna Liu
name: Zhaoshi Xu
name: Liancheng Li
name: Yongbin Zhou
name: Jianjun Liu
name: Zhendong Zhao
name: Chen, Ming
name: Youzhi Ma
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Experimental protocol of iNTT system method. (DOCX 538 kb)
The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients
Creators: name: Parmar, Simran Singh
name: Mohamed, Mohamed O.
name: Mamas, Mamas A.
name: Wilkie, Ross
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: The prevalence of osteoarthritis (OA) and cardiovascular disease are increasing and both conditions share similar risk factors. We investigated the association between OA and receipt of invasive managements and clinical outcomes in patients with acute myocardial infarction (AMI). Using the National Inpatient Sample, adjusted binary logistic regression determined the association between OA and each outcome variable. Of 6,561,940 AMI hospitalizations, 6.3% had OA. OA patients were older and more likely to be female. OA was associated with a decreased odds of coronary angiography (adjusted odds ratio 0.91; 95% confidence interval 0.90, 0.92), PCI (0.87; 0.87, 0.88), and coronary artery bypass grafting (0.98; 0.97, 1.00). OA was associated with a decreased odds of adverse outcomes (in-hospital mortality: 0.68; 0.67, 0.69; major acute cardiovascular and cerebrovascular events: 0.71; 0.70, 0.72; all-cause bleeding: 0.76; 0.74, 0.77; and stroke/TIA: 0.84; 0.82, 0.87). This study of a representative sample of the US population highlights that OA patients are less likely to be offered invasive interventions following AMI. OA was also associated with better outcomes post-AMI, possibly attributed to a misclassification bias where unwell patients with OA were less likely to receive an OA code because codes for serious illness took precedence.
Additional file 2: of Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry
Creators: name: Wanqing Wen
name: Xiao-Ou Shu
name: Xingyi Guo
name: Qiuyin Cai
name: Jirong Long
name: Bolla, Manjeet
name: Michailidou, Kyriaki
name: Dennis, Joe
name: Wang, Qin
name: Yu-Tang Gao
name: Zheng, Ying
name: Dunning, Alison
name: GarcĂ­A-Closas, Montserrat
name: Brennan, Paul
name: Shou-Tung Chen
name: Ji-Yeob Choi
name: Hartman, Mikael
name: Ito, Hidemi
name: Artitaya Lophatananon
name: Keitaro Matsuo
name: Miao, Hui
name: Muir, Kenneth
name: Suleeporn Sangrajrang
name: Shen, Chen-Yang
name: Teo, Soo
name: Chiu-Chen Tseng
name: Wu, Anna
name: Yip, Cheng
name: Simard, Jacques
name: Pharoah, Paul
name: Hall, Per
name: Daehee Kang
name: Yongbing Xiang
name: Easton, Douglas
name: Zheng, Wei
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: is Table S2 presenting the association between selected SNPs and breast cancer risk in East Asian women. (PDF 146 kb)
A cost-effectiveness analysis of empagliflozin for heart failure patients across the full spectrum of ejection fraction in Spain: combined results of the EMPEROR-Preserved and EMPEROR-Reduced trials
Creators: name: García-Moll, Xavier
name: Croci, Francesco
name: Solé, Alexandra
name: Hartgers-Gubbels, Elisabeth S.
name: Calleja-Hernández, Miguel A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Biological Sciences not elsewhere classified
Science Policy

description: Heart failure (HF) is a chronic condition with considerable clinical burden for patients and economic burden for healthcare systems. Treatment for HF is typically based on ejection fraction (EF) phenotype. The cost-effectiveness of empagliflozin + standard of care (SoC) compared to SoC has been examined for HF phenotypes below or above 40% EF separately, but not across the full spectrum of EF in Spain. The results of two preexisting, validated, and published phenotype-specific Markov cohort models were combined using a population-weighted approach, reflecting the incidence of each phenotype in the total HF population in Spain. A probabilistic sensitivity analysis was performed by sampling each model’s probabilistic results. Empagliflozin + SoC compared to SoC resulted in increased life-years (LYs) (6.48 vs. 6.35), quality-adjusted LYs (QALYs) (4.80 vs. 4.63), and healthcare costs (€19,090 vs. €18,246), over a lifetime time horizon for the combined HF population in Spain. The incremental cost-effectiveness ratio (ICER) was €5,089/QALY. All subgroup, scenario, and probabilistic ICERs were consistently below €10,000/QALY. Empagliflozin is the first treatment with established efficacy and cost-effectiveness for HF patients across EF from the perspective of healthcare payers in Spain. Empagliflozin also proved to be cost-effective for all subgroups of patients included in the analysis.
COVID-19 among heart transplant recipients in Germany: a multicenter survey
Creators: name: Rivinius, Rasmus
name: Kaya, Ziya
name: Schramm, René
name: Boeken, Udo
name: Provaznik, Zdenek
name: Heim, Christian
name: Knosalla, Christoph
name: Schoenrath, Felix
name: Rieth, Andreas
name: Berchtold-Herz, Michael
name: Barten, Markus J.
name: Rauschning, Dominic
name: Mücke, Victoria T.
name: Heyl, Stephan
name: Pistulli, Rudin
name: Grinninger, Carola
name: Hagl, Christian
name: Gummert, Jan F.
name: Warnecke, Gregor
name: Schulze, P. Christian
name: Katus, Hugo A.
name: Kreusser, Michael M.
name: Raake, Philip W.
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: REPLICATION; SENSITIVITY; FAILURE; COV; COVID-19; Heart transplantation; Immunosuppression; Mortality
subject: 610 Medizin

description: Aims Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted a nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics of heart transplant recipients with COVID-19 during the first months of the pandemic in Germany. Methods and results A multicenter survey of all heart transplant centers in Germany evaluating the current status of COVID-19 among adult heart transplant recipients was performed. A total of 21 heart transplant patients with COVID-19 was reported to the transplant centers during the first months of the pandemic in Germany. Mean patient age was 58.6 +/- 12.3 years and 81.0% were male. Comorbidities included arterial hypertension (71.4%), dyslipidemia (71.4%), diabetes mellitus (33.3%), chronic kidney failure requiring dialysis (28.6%) and chronic-obstructive lung disease/asthma (19.0%). Most patients received an immunosuppressive drug regimen consisting of a calcineurin inhibitor (71.4%), mycophenolate mofetil (85.7%) and steroids (71.4%). Eight of 21 patients (38.1%) displayed a severe course needing invasive mechanical ventilation. Those patients showed a high mortality (87.5%) which was associated with right ventricular dysfunction (62.5% vs. 7.7%;p = 0.014), arrhythmias (50.0% vs. none;p = 0.012), and thromboembolic events (50.0% vs. none;p = 0.012). Elevated high-sensitivity cardiac troponin T- and N-terminal prohormone of brain natriuretic peptide were significantly associated with the severe form of COVID-19 (p = 0.017 andp < 0.001, respectively). Conclusion Severe course of COVID-19 was frequent in heart transplanted patients. High mortality was associated with right ventricular dysfunction, arrhythmias, thromboembolic events, and markedly elevated cardiac biomarkers.
Additional file 6: Table S4. of Comparative proteomics illustrates the complexity of drought resistance mechanisms in two wheat (Triticum aestivum L.) cultivars under dehydration and rehydration
Creators: name: Lixiang Cheng
name: Yuping Wang
name: He, Qiang
name: Huijun Li
name: Xiaojing Zhang
name: Zhang, Feng
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Identification of differentially abundant proteins associated with drought stress response in Xihan No. 2. Protein identifications were performed by searching for the Viridiplantae index of the NCBInr database using peptide mass fingerprinting (PMF) and MS/MS data from a MALDI-TOF/TOF mass spectrometry analysis. The spot number as given on the 2-DE gel image (shown in Fig. 3), the identified protein name, the source organism, the gene identification number as in GenBank, the number of matched peptides, the statistical score from the database, the sequence coverage (%), the theoretical Mass (kDa)/ pI values retrieved from protein database and the means for relative protein abundance ± standard error (SE) were listed. Spots with a significant differential expression are described as the spot volumes that were significantly different (p
Margo Garrett: Juilliard Journal Features
Creators: name: VanderHart, Chanda
name: Juilliard School
name: Dahmus Farah, Jeni
Publisher: name: Zenodo
Year: 2024

description: 3 cropped .pdf scans of articles and images featuring pianist and pedagogue Margo Garrett from the Juilliard Journal:

Ayres, Alfred 'An Interview with Margo Garrett' October 1988, p. 

Egan, Laury 'A Tribute to Paul Doktor' November 1989, p. 2.

Brown, Lydia 'Margo Garrett Collaborative Piano Teacher Steps Down' April, 2018, p. 9.

 

Juilliard retains the rights to these files; their reproduction or re-publication is prohibited without express permission.
A cost-effectiveness analysis of empagliflozin for heart failure patients across the full spectrum of ejection fraction in Spain: combined results of the EMPEROR-Preserved and EMPEROR-Reduced trials
Creators: name: García-Moll, Xavier
name: Croci, Francesco
name: Solé, Alexandra
name: Hartgers-Gubbels, Elisabeth S
name: Calleja-Hernández, Miguel A
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Biological Sciences not elsewhere classified
Science Policy

description: Heart failure (HF) is a chronic condition with considerable clinical burden for patients and economic burden for healthcare systems. Treatment for HF is typically based on ejection fraction (EF) phenotype. The cost-effectiveness of empagliflozin + standard of care (SoC) compared to SoC has been examined for HF phenotypes below or above 40% EF separately, but not across the full spectrum of EF in Spain. The results of two preexisting, validated, and published phenotype-specific Markov cohort models were combined using a population-weighted approach, reflecting the incidence of each phenotype in the total HF population in Spain. A probabilistic sensitivity analysis was performed by sampling each model’s probabilistic results. Empagliflozin + SoC compared to SoC resulted in increased life-years (LYs) (6.48 vs. 6.35), quality-adjusted LYs (QALYs) (4.80 vs. 4.63), and healthcare costs (€19,090 vs. €18,246), over a lifetime time horizon for the combined HF population in Spain. The incremental cost-effectiveness ratio (ICER) was €5,089/QALY. All subgroup, scenario, and probabilistic ICERs were consistently below €10,000/QALY. Empagliflozin is the first treatment with established efficacy and cost-effectiveness for HF patients across EF from the perspective of healthcare payers in Spain. Empagliflozin also proved to be cost-effective for all subgroups of patients included in the analysis.