cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epigenetic Mechanisms of Mouse Interstrain Variability in Genotoxicity of the Environmental Toxicant 1,3-Butadiene
Creators: name: Sorrentino, Jessica
name: Koturbash, Igor
name: Swenberg, James A.
name: Beland, Frederick A.
name: Pardo-Manuel deVillena, Fernando
name: Scherhag, Anne
name: Pogribny, Igor P.
name: Bodnar, Wanda
name: Sexton, Kenneth
name: Rusyn, Ivan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: 1,3-Butadiene (BD) is a common environmental contaminant classified as “carcinogenic to humans.” Formation of BD-induced DNA adducts plays a major role in its carcinogenicity. BD is also an epigenotoxic agent (i.e., it affects DNA and histone methylation in the liver). We used a panel of genetically diverse inbred mice (NOD/LtJ, CAST/EiJ, A/J, WSB/EiJ, PWK/PhJ, C57BL/6J, and 129S1/SvImJ) to assess whether BD-induced genotoxic and epigenotoxic events may be subject to interstrain differences. Mice (male, 7 weeks) were exposed via inhalation to 0 or 625 ppm BD for 6 h/day and 5 days/week for 2 weeks and liver BD-DNA adducts, epigenetic alterations, and liver toxicity were assessed. N-7-(2,3,4-trihydroxybut-1-yl)-guanine adducts were detected in all strains after exposure, yet BD-induced DNA damage in CAST/EiJ mice was two to three times lower. Epigenetic effects of BD were most prominent in C57BL/6J mice where loss of global DNA methylation and loss of trimethylation of histone H3 lysine 9, histone H3 lysine 27, and histone H4 lysine 20, accompanied by dysregulation of liver gene expression indicative of hepatotoxicity, were found. Interestingly, we observed an increase in histone methylation in the absence of changes in gene expression and DNA methylation in CAST/EiJ strain. We hypothesized that mitigated genotoxicity of BD in CAST/EiJ mice may be due to chromatin condensation. Indeed, we show that in response to BD exposure, chromatin condensation occurs in CAST/EiJ, whereas the opposite effect is observed in C57BL/6J mice. These findings demonstrate that interstrain susceptibility to genotoxicity by a well-known environmental carcinogen may be due to strain-specific epigenetic events in response to the exposure.
title: "Maîtresse, pourquoi tu parles fort ?" : La prosodie, un marqueur de sens lors de consignes orales au cycle 1 et 2
title: "Maîtresse, pourquoi tu parles fort ?" : La prosodie, un marqueur de sens lors de consignes orales au cycle 1 et 2
titleType: AlternativeTitle
Creators: name: Studli, Aurélia
name: Hayoz, Véronique
Publisher: name: Unknown
Year: 0
Subjects: subject: prosodie
subject: consigne
subject: voix
subject: geste vocal
subject: communication non verbale
subject: enseignement primaire

description: Ce mémoire porte sur les modulations de la voix, à savoir la prosodie, dans l’enseignement primaire. Les consignes font partie intégrante du paysage scolaire. Nous nous axons donc sur la prosodie lors de consignes et la recherche de ce travail consiste à déterminer quelles variations prosodiques sont à privilégier lors de consignes orales. De plus, elle vise à comparer les variations prosodiques émises par les enseignantes des deux cycles du primaire (1-2H et 8H) dans le but de découvrir un geste vocal propre à un enseignant de classe enfantine et à un enseignant de classe de préadolescents. Pour ce faire, nous avons choisi une méthode quasi expérimentale. Un groupe témoin et un groupe expérimental sont déterminés pour les deux classes afin de tester certains traits prosodiques lors de nos consignes qui sont suivies d’une tâche. Nous les avons ainsi comparées à l’aide d’un logiciel qui permet une écoute fine des variations de la voix. L’analyse de ces consignes orales a permis de dégager des observations concernant la réussite de la tâche entre le groupe témoin et le groupe expérimental, mais également entre la voix de l’enseignante du cycle 1 et celle du cycle 2. A travers la définition de divers concepts liés à la prosodie, nous mettons en relation notre cadre théorique à nos observations menées lors de l’analyse.
Additional file 1 of Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in Waves 1 through 5 (2013–2019) of the Population Assessment of Tobacco and Health (PATH) Study
Creators: name: Paulin, Laura M.
name: Halenar, Michael J.
name: Edwards, Kathryn C.
name: Lauten, Kristin
name: Stanton, Cassandra A.
name: Taylor, Kristie
name: Hatsukami, Dorothy
name: Hyland, Andrew
name: MacKenzie, Todd
name: Mahoney, Martin C.
name: Niaura, Ray
name: Trinidad, Dennis
name: Blanco, Carlos
name: Compton, Wilson M.
name: Gardner, Lisa D.
name: Kimmel, Heather L.
name: Lauterstein, Dana
name: Marshall, Daniela
name: Sargent, James D.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 1. Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in Waves 1 through 5 (2013–2019) of the Population Assessment of Tobacco and Health (PATH) Study.
In Vitro Screening for Population Variability in Chemical Toxicity
Creators: name: Ross, Pamela K.
name: Rusyn, Ivan
name: Ha, Min Jin
name: Wright, Fred A.
name: O'Shea, Shannon H.
name: Schwarz, John
name: Kosyk, Oksana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Immortalized human lymphoblastoid cell lines have been used to demonstrate that it is possible to use an in vitro model system to identify genetic factors that affect responses to xenobiotics. To extend the application of such studies to investigative toxicology by assessing interindividual and population-wide variability and heritability of chemical-induced toxicity phenotypes, we have used cell lines from the Centre d'Etude du Polymorphisme Humain (CEPH) trios assembled by the HapMap Consortium. Our goal is to aid in the development of predictive in vitro genetics-anchored models of chemical-induced toxicity. Cell lines from the CEPH trios were exposed to three concentrations of 14 environmental chemicals. We assessed ATP production and caspase-3/7 activity 24 h after treatment. Replicate analyses were used to evaluate experimental variability and classify responses. We show that variability of response across the cell lines exists for some, but not all, chemicals, with perfluorooctanoic acid (PFOA) and phenobarbital eliciting the greatest degree of interindividual variability. Although the data for the chemicals used here do not show evidence for broad-sense heritability of toxicity response phenotypes, substantial cell line variation was found, and candidate genetic factors contributing to the variability in response to PFOA were investigated using genome-wide association analysis. The approach of screening chemicals for toxicity in a genetically defined yet diverse in vitro human cell-based system is potentially useful for identification of chemicals that may pose a highest risk, the extent of within-species variability in the population, and genetic loci of interest that potentially contribute to chemical susceptibility.
Interstrain Differences in the Liver Effects of Trichloroethylene in a Multistrain Panel of Inbred Mice
Creators: name: Threadgill, David W.
name: Pogribny, Igor P.
name: Uehara, Takeki
name: Bradford, Blair U.
name: Kosyk, Oksana
name: Harbourt, David
name: Lock, Eric F.
name: Bleyle, Lisa
name: Kim, Sungkyoon
name: Rusyn, Ivan
name: Koop, Dennis R.
name: Tryndyak, Volodymyr
name: DeSimone, Michelle
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Trichloroethylene (TCE) is a widely used industrial chemical and a common environmental contaminant. It is a well-known carcinogen in rodents and a probable carcinogen in humans. Studies utilizing panels of mouse inbred strains afford a unique opportunity to understand both metabolic and genetic basis for differences in responses to TCE. We tested the hypothesis that strain- and liver-specific toxic effects of TCE are genetically controlled and that the mechanisms of toxicity and susceptibility can be uncovered by exploring responses to TCE using a diverse panel of inbred mouse strains. TCE (2100 mg/kg) or corn oil vehicle was administered by gavage to 6- to 8-week-old male mice of 15 mouse strains. Serum and liver were collected at 2, 8, and 24 h postdosing and were analyzed for TCE metabolites, hepatocellular injury, and gene expression of liver. TCE metabolism, as evident from the levels of individual oxidative and conjugative metabolites, varied considerably between strains. TCE treatment-specific effect on the liver transcriptome was strongly dependent on genetic background. Peroxisome proliferator–activated receptor–mediated molecular networks, consisting of the metabolism genes known to be induced by TCE, represent some of the most pronounced molecular effects of TCE treatment in mouse liver that are dependent on genetic background. Conversely, cell death, liver necrosis, and immune-mediated response pathways, which are altered by TCE treatment in liver, are largely genetic background independent. These studies provide better understanding of the mechanisms of TCE-induced toxicity anchored on metabolism and genotype-phenotype correlations that may define susceptibility or resistance.
title: Μελέτη, καταγραφή και αποτίμηση εκπαιδευτικών δεδομένων εξόρυξης από την εξ αποστάσεως εξεταστική διαδικασία μέσω σχετικών εργαλείων λογισμικού
title: Study, recording and evaluation of educational data from remote examination process through relevant software tools
titleType: AlternativeTitle
Creators: name: Πολίτης, Νικόλαος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Εξ' αποστάσεως εξέταση
Έρευνα
Εκπαιδευτικά δεδομένα
Ερωτηματολόγιο

description: Η πτυχιακή αυτή θα εστιάζει στην μελέτη, την καταγραφή αλλά και την αποτίμηση των δεδομένων από τον χώρο της εκπαίδευσης, τα οποία θα βασίζονται στις εξ αποστάσεως εξετάσεις, ως διαδικασία αξιόλογησης, που διεξάγονται μέσω των ποικίλων διαθέσιμων εργαλείων λογισμικού για την επιτυχή διεκπεραίωσή τους.
Manganese Accumulation in the Olfactory Bulbs and Other Brain Regions of “Asymptomatic” Welders
Creators: name: Huang, Xuemei
name: An, Hongyu
name: Tröster, Alexander I.
name: Du, Guangwei
name: Sen, Suman
name: Flynn, Michael R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Welding-generated metallic fumes contain a substantial amount of manganese (Mn), making welders susceptible to Mn toxicity. Although overt Mn toxicity manifests as a type of parkinsonism, the consequences of chronic, low-level Mn exposure are unknown. To explore region-specific Mn accumulation and its potential functional consequences at subclinical levels of Mn exposure, we studied seven welders without obvious neurological deficits and seven age- and gender-matched controls. Mn exposure for welders was estimated by an occupational questionnaire. High-resolution brain magnetic resonance imaging (MRI), Grooved Pegboard performance of both hands, Trail making, and olfactory function tests were obtained from all subjects. Compared with controls, the welders had a significantly higher T1 relaxation rate (R1) in the olfactory bulb (OB, p = 0.02), mean T1-weighted intensity at frontal white matter (FWM; p = 0.01), bilateral globus pallidus (GP; p = 0.03), and putamen (p = 0.03). The welders scored worse than the controls on the Grooved Pegboard test for both dominant (p = 0.06) and nondominant hand (p = 0.03). The dominant hand Grooved Pegboard scores correlated best with mean MRI intensity of FWM (R2 = 0.51, p = 0.004), GP (R2 = 0.51, p = 0.004), putamen (R2 = 0.49, p= 0.006), and frontal gray matter (R2 = 0.42, p = 0.01), whereas the nondominant hand scores correlated best with intensity of FWM (R2 = 0.37, p = 0.02) and GP (R2 = 0.28, p = 0.05). No statistical differences were observed in either the Trail-making test or the olfactory test between the two groups. This study suggests that Mn accumulates in OB and multiple other brain regions in “asymptomatic” welders and that MRI abnormalities correlate with fine motor but not cognitive deficits. Further investigations of subclinical Mn exposure are warranted.
Prenatal Perfluorooctanoic Acid Exposure in CD-1 Mice: Low-Dose Developmental Effects and Internal Dosimetry
Creators: name: Fenton, Suzanne E.
name: White, Sally S.
name: Strynar, Mark J.
name: Zehr, Robert D.
name: Villanueva, LaTonya R.
name: Stanko, Jason P.
name: Macon, Madisa B.
name: Helfant, Laurence
name: Tatum-Gibbs, Katoria
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Perfluorooctanoic acid (PFOA) is an environmental contaminant that causes adverse developmental effects in laboratory animals. To investigate the low-dose effects of PFOA on offspring, timed-pregnant CD-1 mice were gavage dosed with PFOA for all or half of gestation. In the full-gestation study, mice were administered 0, 0.3, 1.0, and 3.0 mg PFOA/kg body weight (BW)/day from gestation days (GD) 1–17. In the late-gestation study, mice were administered 0, 0.01, 0.1, and 1.0 mg PFOA/kg BW/day from GD 10–17. Exposure to PFOA significantly (p < 0.05) increased offspring relative liver weights in all treatment groups in the full-gestation study and in the 1.0 mg PFOA/kg group in the late-gestation study. In both studies, the offspring of all PFOA-treated dams exhibited significantly stunted mammary epithelial growth as assessed by developmental scoring. At postnatal day 21, mammary glands from the 1.0 mg/kg GD 10–17 group had significantly less longitudinal epithelial growth and fewer terminal end buds compared with controls (p < 0.05). Evaluation of internal dosimetry in offspring revealed that PFOA concentrations remained elevated in liver and serum for up to 6 weeks and that brain concentrations were low and undetectable after 4 weeks. These data indicate that PFOA-induced effects on mammary tissue (1) occur at lower doses than effects on liver weight in CD-1 mice, an observation that may be strain specific, and (2) persist until 12 weeks of age following full-gestational exposure. Due to the low-dose sensitivity of mammary glands to PFOA in CD-1 mice, a no observable adverse effect level for mammary developmental delays was not identified in these studies.
On the second homology group of the Torelli subgroup of Aut(F_n)
Creators: name: Day, Matthew B.
name: Putman, Andrew
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Topology (math.AT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: Let IA_n be the Torelli subgroup of Aut(F_n). We give an explicit finite set of generators for H_2(IA_n) as a GL_n(Z)-module. Corollaries include a version of surjective representation stability for H_2(IA_n), the vanishing of the GL_n(Z)-coinvariants of H_2(IA_n), and the vanishing of the second rational homology group of the level l congruence subgroup of Aut(F_n). Our generating set is derived from a new group presentation for IA_n which is infinite but which has a simple recursive form.
description: 39 pages; minor revision; to appear in Geom. Topol
Role of Fibrinogen and Protease-Activated Receptors in Acute Xenobiotic-Induced Cholestatic Liver Injury
Creators: name: Luyendyk, James P.
name: Sullivan, Bradley P.
name: Mackman, Nigel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Alpha-naphthylisothiocyanate (ANIT)–induced cholestatic liver injury causes tissue factor (TF)–dependent coagulation in mice, and TF deficiency reduces ANIT-induced liver injury. However, the mechanism whereby TF contributes to hepatotoxicity in this model is not known. Utilizing pharmacological and genetic strategies, we evaluated the contribution of fibrinogen and two distinct receptors for thrombin, protease-activated receptor-1 (PAR-1) and PAR-4, in a model of acute ANIT hepatotoxicity. ANIT administration (60 mg/kg, po) caused a marked induction of the genes encoding the three fibrinogen chains (α, β, and γ) in liver, an increase in plasma fibrinogen, and concurrent deposition of thrombin-cleaved fibrin in liver. Partial depletion of circulating fibrinogen with ancrod did not impact ANIT hepatotoxicity. However, complete fibrin(ogen) deficiency significantly reduced serum alanine aminotransferase activity and hepatocellular necrosis in ANIT-treated mice. ANIT-induced hepatocellular necrosis was similar in PAR-1−/− mice compared with PAR-1+/+ mice. Interestingly, the progression of ANIT-induced hepatocellular necrosis was significantly reduced in PAR-4−/− mice and by administration of an inhibitory PAR-4 pepducin (P4Pal-10, 0.5 mg/kg, sc) to wild-type mice 8 h after ANIT treatment. Interestingly, a distinct lesion, parenchymal-type peliosis, was also observed in PAR-4−/− mice treated with ANIT and in mice that were given P4Pal-10 prior to ANIT administration. The results suggest that fibrin(ogen), but not PAR-1, contributes to the progression of ANIT hepatotoxicity in mice. Moreover, the data suggest a dual role for PAR-4 in ANIT hepatotoxicity, both mediating an early protection against peliosis and contributing to the progression of hepatocellular necrosis.
The motion of a deforming capsule through a corner
Creators: name: Zhu, Lailai
name: Brandt, Luca
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: A three-dimensional deformable capsule convected through a square duct with a corner is studied via numerical simulations. We develop an accelerated boundary integral implementation adapted to general geometries and boundary conditions. A global spectral method is adopted to resolve the dynamics of the capsule membrane developing elastic tension according to the neo-Hookean constitutive law and bending moments in an inertialess flow. The simulations show that the trajectory of the capsule closely follows the underlying streamlines independently of the capillary number. The membrane deformability, on the other hand, significantly influences the relative area variations, the advection velocity and the principal tensions observed during the capsule motion. The evolution of the capsule velocity displays a loss of the time-reversal symmetry of Stokes flow due to the elasticity of the membrane. The velocity decreases while the capsule is approaching the corner as the background flow does, reaches a minimum at the corner and displays an overshoot past the corner due to the streamwise elongation induced by the flow acceleration in the downstream branch. This velocity overshoot increases with confinement while the maxima of the major principal tension increase linearly with the inverse of the duct width. Finally, the deformation and tension of the capsule are shown to decrease in a curved corner.
Additional file 1 of Working with alcohol prevention in occupational health services: “knowing how” is more important than “knowing that” – the WIRUS OHS study
Creators: name: Thørrisen, Mikkel Magnus
name: Sadeghi, Talieh
name: Bonsaksen, Tore
name: Graham, Ian D.
name: Aas, Randi Wågø
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Component structure and internal consistency for the alcohol knowledge items.
Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference
Creators: name: Berry, Sir Colin L.
name: Weiss, Noel S.
name: Breckenridge, Charles B.
name: Adami, Hans-Olov
name: Swenberg, James A.
name: Pastoor, Timothy P.
name: Smith, Lewis L.
name: Trichopoulos, Dimitrios
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Historically, toxicology has played a significant role in verifying conclusions drawn on the basis of epidemiological findings. Agents that were suggested to have a role in human diseases have been tested in animals to firmly establish a causative link. Bacterial pathogens are perhaps the oldest examples, and tobacco smoke and lung cancer and asbestos and mesothelioma provide two more recent examples. With the advent of toxicity testing guidelines and protocols, toxicology took on a role that was intended to anticipate or predict potential adverse effects in humans, and epidemiology, in many cases, served a role in verifying or negating these toxicological predictions. The coupled role of epidemiology and toxicology in discerning human health effects by environmental agents is obvious, but there is currently no systematic and transparent way to bring the data and analysis of the two disciplines together in a way that provides a unified view on an adverse causal relationship between an agent and a disease. In working to advance the interaction between the fields of toxicology and epidemiology, we propose here a five-step “Epid-Tox” process that would focus on: (1) collection of all relevant studies, (2) assessment of their quality, (3) evaluation of the weight of evidence, (4) assignment of a scalable conclusion, and (5) placement on a causal relationship grid. The causal relationship grid provides a clear view of how epidemiological and toxicological data intersect, permits straightforward conclusions with regard to a causal relationship between agent and effect, and can show how additional data can influence conclusions of causality.
Additional file 2 of Working with alcohol prevention in occupational health services: “knowing how” is more important than “knowing that” – the WIRUS OHS study
Creators: name: Thørrisen, Mikkel Magnus
name: Sadeghi, Talieh
name: Bonsaksen, Tore
name: Graham, Ian D.
name: Aas, Randi Wågø
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Descriptions of measures utilized in sensitivity analyses.
Universality in one-dimensional fermions at finite temperature: Density, pressure, compressibility, and contact
Creators: name: Hoffman, M. D.
name: Javernick, P. D.
name: Loheac, A. C.
name: Porter, W. J.
name: Anderson, E. R.
name: Drut, J. E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present finite-temperature, lattice Monte Carlo calculations of the particle number density, compressibility, pressure, and Tan's contact of an unpolarized system of short-range, attractively interacting spin-1/2 fermions in one spatial dimension, i.e., the Gaudin-Yang model. In addition, we compute the second-order virial coefficients for the pressure and the contact, both of which are in excellent agreement with the lattice results in the low-fugacity regime. Our calculations yield universal predictions for ultracold atomic systems with broad resonances in highly constrained traps. We cover a wide range of couplings and temperatures and find results that support the existence of a strong-coupling regime in which the thermodynamics of the system is markedly different from the noninteracting case. We compare and contrast our results with identical systems in higher dimensions.
description: 6 pages, 7 figures; improved, published version
title: Τοπίο
title: Landscape
titleType: AlternativeTitle
Creators: name: Κατσιάνου, Θάλεια
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Τοπίο
Αρκαδισμός
Αττική

description: Στη παρακάτω μελέτη, κεντρικό θέμα είναι το τοπίο. Πρόκειται για μια προσέγγιση του τοπίου στο οποίο απουσιάζει η ανθρώπινη παρουσία. Αρχικά, ορίζεται το τοπίο ως είδος (genre), καθώς και οι δυο μεγάλες κατηγορίες του : το Γραφικό και το Υψηλό. Σε αυτό το πλαίσιο, για την καλύτερη κατανόηση θα αναφερθούν ζωγράφοι που έχουν ασχοληθεί με αυτές τις δυο κατηγορίες. Ως προς το Γραφικό, παρουσιάζεται το έργο του ζωγράφου John Constable (1776-1837) και ως προς το Υψηλό, εξετάζεται το έργο του ζωγράφου William Turner (1775-1851) καθώς και ο τρόπος που απεικονίζονται τα τοπία αυτά στους πίνακές τους. Στη συνέχεια, μελετάται το Αρκαδικό τοπίο με αναφορές στο έργο του ζωγράφου Nikolas Poussin (1594-1665). Τέλος, γίνεται μια προσπάθεια σύνδεσης των εικονογραφικών χαρακτηριστικών του αρκαδικού τοπίου, ως κατηγορία, με τοπία της Αττικής που συμπεριλαμβάνονται στο φωτογραφικό έργο μου. Τέλος, εξετάζονται οι σύγχρονοι φωτογράφοι Fay Godwin (1931- 2005) και ο Πάρις Πετρίδης(1960-) καθώς και οι καλλιτέχνες Ed Hill και Suzanne Bloom, για την ενασχόληση τους με το αρκαδικό τοπίο.
Geodesic Motion in Schwarzschild Spacetime Surrounded by Quintessence
Creators: name: Uniyal, Rashmi
name: Devi, N. Chandrachani
name: Nandan, Hemwati
name: Purohit, K. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the time-like geodesic congruences, in the space-time geometry of a Schwarzschild black hole surrounded by quintessence. The nature of effective potential along with the structure of the possible orbits for test particles in view of the different values of quintessence parameter are analysed in detail. %wherever possible it is done analytically otherwise numerically. An increase in quintessence parameter is seen to set the particles from farther distance into motion around black hole. The effect of quintessence parameter is investigated analytically wherever possible otherwise we perform the numerical analysis to probe the structure of possible orbits. It is observed that there exist a number of different possible orbits for a test particle in case of non-radial geodesics, such as circular (stable as well as unstable) bound orbits, radially plunge and fly-by orbits, whereas no bound orbits exist in case of radial geodesics. Using the geodesic deviation equations, we obtain the corresponding deviation vector and find that the quintessence assists the divergence of neighbouring geodesics in both the radial and transverse directions.
description: 20 pages, 8 figures
N3C Results Download Policy
Creators: name: O'Neil, Shawn
name: Walden, Anita
name: Suver, Christine
name: Loomba, Johanna
name: Chute, Chris
name: Haendel, Melissa
Publisher: name: Zenodo
Year: 2023
Subjects: governance
rwd data

description: Investigators using the rich data compiled in the N3C Data Enclave are expected to generate quantitative results in the forms of tables, figures, parameter estimates, and aggregated statistics. These results may have broad impact and will be shared, typically in the form of manuscripts, reports, and visualizations for websites and seminars. Additionally, many artifacts such as workflows, value sets, and phenotyping algorithms may be developed in the Enclave and made useful to others by being exported for presentation on public websites such as GitHub, or incorporated as supplementary materials to publications. The purpose of this policy is to establish a process to permit the download of quantitative artifacts used in analyses that are necessary for sharing results, while at the same time ensuring protection and security of the data in the Enclave and compliance with the NCATS Data Transfer and Data Use Agreements.
Additional file 3 of Working with alcohol prevention in occupational health services: “knowing how” is more important than “knowing that” – the WIRUS OHS study
Creators: name: Thørrisen, Mikkel Magnus
name: Sadeghi, Talieh
name: Bonsaksen, Tore
name: Graham, Ian D.
name: Aas, Randi Wågø
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Comparisons between completers and non-completers.
A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models
Creators: name: Eaddy, J. Scott
name: Wolf, Kristina K.
name: DeSmet, Kristina D.
name: Watkins, Paul B.
name: Kurtz, C. Lisa
name: Hall, J. Ed.
name: Harrill, Alison H.
name: Bridges, Arlene S.
name: Tidwell, Richard R.
name: Paine, Mary F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: DB289 is the first oral drug shown in clinical trials to have efficacy in treating African trypanosomiasis (African sleeping sickness). Mild liver toxicity was noted but was not treatment limiting. However, development of DB289 was terminated when several treated subjects developed severe kidney injury, a liability not predicted from preclinical testing. We tested the hypothesis that the kidney safety liability of DB289 would be detected in a mouse diversity panel (MDP) comprised of 34 genetically diverse inbred mouse strains. MDP mice received 10 days of oral treatment with DB289 or vehicle and classical renal biomarkers blood urea nitrogen (BUN) and serum creatinine (sCr), as well as urine biomarkers of kidney injury were measured. While BUN and sCr remained within reference ranges, marked elevations were observed for kidney injury molecule-1 (KIM-1) in the urine of sensitive mouse strains. KIM-1 elevations were not always coincident with elevations in alanine aminotransferase (ALT), suggesting that renal injury was not linked to hepatic injury. Genome-wide association analyses of KIM-1 elevations indicated that genes participating in cholesterol and lipid biosynthesis and transport, oxidative stress, and cytokine release may play a role in DB289 renal injury. Taken together, the data resulting from this study highlight the utility of using an MDP to predict clinically relevant toxicities, to identify relevant toxicity biomarkers that may translate into the clinic, and to identify potential mechanisms underlying toxicities. In addition, the sensitive mouse strains identified in this study may be useful in screening next-in-class compounds for renal injury.
Additional file 4 of Working with alcohol prevention in occupational health services: “knowing how” is more important than “knowing that” – the WIRUS OHS study
Creators: name: Thørrisen, Mikkel Magnus
name: Sadeghi, Talieh
name: Bonsaksen, Tore
name: Graham, Ian D.
name: Aas, Randi Wågø
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Study selection analysis.
Krylov subspace methods for the Dirac equation
Creators: name: Beerwerth, Randolf
name: Bauke, Heiko
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Lanczos algorithm is evaluated for solving the time-independent as well as the time-dependent Dirac equation with arbitrary electromagnetic fields. We demonstrate that the Lanczos algorithm can yield very precise eigenenergies and allows very precise time propagation of relativistic wave packets. The unboundedness of the Dirac Hamiltonian does not hinder the applicability of the Lanczos algorithm. As the Lanczos algorithm requires only matrix-vector products and inner products, which both can be efficiently parallelized, it is an ideal method for large-scale calculations. The excellent parallelization capabilities are demonstrated by a parallel implementation of the Dirac Lanczos propagator utilizing the Message Passing Interface standard.
Formation of 1,2:3,4-Diepoxybutane-Specific Hemoglobin Adducts in 1,3-Butadiene Exposed Workers
Creators: name: Albertini, Richard J.
name: Georgieva, Nadia I.
name: Šram, Radim J.
name: Boysen, Gunnar
name: Bordeerat, Narisa K.
name: Vacek, Pamela
name: Swenberg, James A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: 1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to its metabolism to several reactive epoxide metabolites and formation of the highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been hypothesized to drive mutagenesis and carcinogenesis at exposures experienced in humans. We report herein the formation of DEB-specific N,N-(2,3-dihydroxy-1,4-butadiyl)valine (pyr-Val) in BD-exposed workers as a biomarker of DEB formation. pyr-Val was determined in BD monomer and polymer plant workers that had been previously analyzed for several other biomarkers of exposure and effect. pyr-Val was detected in 68 of 81 (84%) samples ranging from 0.08 to 0.86 pmol/g globin. Surprisingly, pyr-Val was observed in 19 of 23 administrative control subjects not known to be exposed to BD, suggesting exposure from environmental sources of BD. The mean ± SD amounts of pyr-Val were 0.11 ± 0.07, 0.16 ± 0.12, and 0.29 ± 0.20 pmol/g globin in the controls, monomer, and polymer workers, respectively, clearly demonstrating formation of DEB in humans. The amounts of pyr-Val found in this study suggest that humans are much less efficient in the formation of DEB than mice or rats at similar exposures. Formation of pyr-Val was more than 50-fold lower than has been associated with increased mutagenesis in rodents. The results further suggest that formation of DEB relative to other epoxides is significantly different in the highest exposed polymer workers compared with controls and BD monomer workers. Whether this is due to saturation of metabolic formation or increased GST-mediated detoxification could not be determined.
Permutations avoiding 1324 and patterns in Łukasiewicz paths
Creators: name: Bevan, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A05, 05A16

description: The class Av(1324), of permutations avoiding the pattern 1324, is one of the simplest sets of combinatorial objects to define that has, thus far, failed to reveal its enumerative secrets. By considering certain large subsets of the class, which consist of permutations with a particularly regular structure, we prove that the growth rate of the class exceeds 9.81. This improves on a previous lower bound of 9.47. Central to our proof is an examination of the asymptotic distributions of certain substructures in the Hasse graphs of the permutations. In this context, we consider occurrences of patterns in Łukasiewicz paths and prove that in the limit they exhibit a concentrated Gaussian distribution.
description: 20 pages, 12 figures
Could Scaling Up Time Currencies Reduce Working Time, EnlargeParticipatory Democracy and Redistribute Wealth?
Creators: name: Théret, Bruno
Publisher: name: International Journal of Community Currency Research (IJCCR)
Year: 2018
Subjects: work time reduction
participative democracy
time currency
public finance

description: In this article we present a proposal of a scaled-up time bank andcurrency at the national level. The aim of such a time currencymanaged by the State (or any regional public power) would be to link alegal reduction of work time in the market sphere to the developmentof an active - participatory - citizenship, and a reduction ofeconomic inequalities through a redistribution of wealth.Paradoxically, we spend much of our lives working in order to financethrough taxes political and administrative activities that we couldfor the most part exercise ourselves, yet from which we are excludedbecause of the rationing of disposable political time and theliberal-bureaucratic constitution of the state. The proposal startsfrom the idea that taxes paid for by additional work in a capitalisteconomy can be at least partially replaced by transferring work hoursfrom market to civic activities. It entails that the reduction of worktime should be seen not only as a way to reduce unemployment in themarket sphere, but also as a political device allowing the developmentof participatory democracy through the payment of taxes "in kind",i.e. in hours of political and administrative activities. Moreover,the value of these activities could be recognized by a national timebank or treasury issuing a time currency which would be required inorder to pay a democratically determined share of the tax burden. Thisdevice would be all the more interesting in that it would notnecessarily imply lower salaries or re-investable profit. All thatwould be required is that reduced work hours be matched by tax cutsaccompanied by corresponding cuts in public spending. The latter, inturn, would be offset by increased civic involvement in politicalactivity and public services. The impact of this transfer of time oneconomic inequalities could be overwhelming but would depend of thetariff of national time currency in the legal tender market currency.
Formation of Hydroxymethyl DNA Adducts in Rats Orally Exposed to Stable Isotope Labeled Methanol
Creators: name: Swenberg, James A.
name: Moeller, Benjamin C.
name: Upton, Patricia B.
name: Gul, Husamettin
name: Lu, Kun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Methanol is a large volume industrial chemical and widely used solvent and fuel additive. Methanol’s well known toxicity and use in a wide spectrum of applications has raised long-standing environmental issues over its safety, including its carcinogenicity. Methanol has not been listed as a carcinogen by any regulatory agency; however, there are debates about its carcinogenic potential. Formaldehyde, a metabolite of methanol, has been proposed to be responsible for the carcinogenesis of methanol. Formaldehyde is a known carcinogen and actively targets DNA and protein, causing diverse DNA and protein damage. However, formaldehyde-induced DNA adducts arising from the metabolism of methanol have not been reported previously, largely due to the absence of suitable DNA biomarkers and the inability to differentiate what was due to methanol compared with the substantial background of endogenous formaldehyde. Recently, we developed a unique approach combining highly sensitive liquid chromatography-mass spectrometry methods and exposure to stable isotope labeled chemicals to simultaneously quantify formaldehyde-specific endogenous and exogenous DNA adducts. In this study, rats were exposed daily to 500 or 2000 mg/kg [13CD4]-methanol by gavage for 5 days. Our data demonstrate that labeled formaldehyde arising from [13CD4]-methanol induced hydroxymethyl DNA adducts in multiple tissues in a dose-dependent manner. The results also demonstrated that the number of exogenous DNA adducts was lower than the number of endogenous hydroxymethyl DNA adducts in all tissues of rats administered 500 mg/kg per day for 5 days, a lethal dose to humans, even after incorporating an average factor of 4 for reduced metabolism due to isotope effects of deuterium-labeled methanol into account.
Additional file 1 of Point-of-care platelet function testing for guided transfusion in neurosurgical management of intracranial hemorrhage: a systematic review
Creators: name: Xu, Flora Wen Xin
name: Lim, Nicole-Ann
name: Sim, Ming Ann
name: Lean, Lyn Li
name: Loh, Ne-Hooi Will
name: Ng, Ka Ting
name: Chua, Vanessa Tze Yuh
name: Chew, Sophia Tsong Huey
name: Ti, Lian Kah
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file1: Table S1. Study quality assessment using Newcastle Ottawa Scale for Cohort Studies and Case–Control Studies. Table S2 Study quality assessment using JBI Checklist for Case Series.
"O Author, Where Art Thou?" An Analysis of Affiliation Indexing in Canadian Journals and Bibliometric Research Potential
Creators: name: van Bellen, Simon
Publisher: name: Zenodo
Year: 2023
Subjects: indexing, Canadian scholarly publishing, author affiliation, persistent identifier, social sciences, humanities, open access, Dimensions, OpenAlex

description: Presentation on the level of author affiliation indexing in Canadian scholarly journals, CAIS-ACSI 2023 online conference.
Quantum-speed-limit time for multiqubit open systems
Creators: name: Liu, Chen
name: Xu, Zhen-Yu
name: Zhu, Shiqun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum-speed-limit (QSL) time captures the intrinsic minimal time interval for a quantum system evolving from an initial state to a target state. In single qubit open systems, it was found that the memory (non-Markovian) effect of environment plays an essential role in shortening QSL time or, say, increasing the capacity for potential speedup. In this paper, we investigate the QSL time for multiqubit open systems. We find that for a certain class of states the memory effect still acts as the indispensable requirement for cutting the QSL time down, while for another class of states this takes place even when the environment is of no memory. In particular, when the initial state is in product state |111...1>, there exists a sudden transition from no capacity for potential speedup to potential speedup in a memoryless environment. In addition, we also display evidence for the subtle connection between QSL time and entanglement that weak entanglement may shorten QSL time even more.
description: 5pages, 3 figures
Chiral Hall Effect and Chiral Electric Waves
Creators: name: Pu, Shi
name: Wu, Shang-Yu
name: Yang, Di-Lun
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate the vector and axial currents induced by external electromagnetic fields and chemical potentials in chiral systems at finite temperature. Similar to the normal Hall effect, we find that an axial Hall current is generated in the presence of the electromagnetic fields along with an axial chemical potential, which may be dubbed as the "chiral Hall effect"(CHE). The CHE is related to the interactions of chiral fermions and exists with the a nonzero axial chemical potential. We argue that the CHE could lead to nontrivial charge distributions at different rapidity in asymmetric heavy ion collisions. Moreover, we study the chiral electric waves(CEW) led by the fluctuations of the vector and axial chemical potentials along with the chiral electric separation effect(CESE), where a density wave propagates along the applied electric field. Combining with the normal/chiral Hall effects, the fluctuations of chemical potentials thus result in Hall density waves. The Hall density waves may survive even at zero chemical potentials and become non-dissipative. We further study the transport coefficients including the Hall conductivities, damping times, wave velocities, and diffusion constants of CEW in a strongly coupled plasma via the AdS/CFT correspondence.
description: 36 pages, 12 figures, sec.IV modified, journal version accepted by PRD
The last sunset on mainland Europe
Creators: name: Mira, Jorge
Publisher: name: arXiv
Year: 2014
Subjects: subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: This paper documents the places in mainland Europe at which the sun sets latest, by Coordinated Universal Time (UTC), on any given day (distortion due to differences in local standard times is ignored). In contradiction to the naïve assumption that the sun always sets latest at the westernmost point, the point of last sunset changes cyclically over the course of a year due to the changing orientation of the axis of the Earth with respect to the sun. Specifically, between the winter and summer solstices the last sunset shifts successively from Cabo de Sao Vicente (Portugal) to Cabo da Roca (Portugal) to Cabo Tourinan (Spain) to a site near Aglapsvik (Norway) to a location in the Norwegian municipality of Masoy south of Havoysund; and it shifts back again between the summer and winter solstices. There are two days in the year (April 24th and August 18th) on which the last sunset of mainland Europe (shared in those days effectively by Cabo Tourinan and the Aglapsvik area) coincides with the last sunset of mainland Africa, at a site in Western Sahara near Cap Blanc. A similar analysis of the first Spanish sunrise shows that from April 22nd to August 20th it occurs on the Costa Brava at Cap de Creus (Catalonia), and the rest of the year at Punta de s'Espero (Balearic Islands), the easternmost point of Spain.
description: 20 pages, 6 figures, 1 table
Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data
Creators: name: Rusyn, Ivan
name: Sedykh, Alexander
name: Low, Yen
name: Guyton, Kathryn Z.
name: Tropsha, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Quantitative structure-activity relationship (QSAR) models are widely used for in silico prediction of in vivo toxicity of drug candidates or environmental chemicals, adding value to candidate selection in drug development or in a search for less hazardous and more sustainable alternatives for chemicals in commerce. The development of traditional QSAR models is enabled by numerical descriptors representing the inherent chemical properties that can be easily defined for any number of molecules; however, traditional QSAR models often have limited predictive power due to the lack of data and complexity of in vivo endpoints. Although it has been indeed difficult to obtain experimentally derived toxicity data on a large number of chemicals in the past, the results of quantitative in vitro screening of thousands of environmental chemicals in hundreds of experimental systems are now available and continue to accumulate. In addition, publicly accessible toxicogenomics data collected on hundreds of chemicals provide another dimension of molecular information that is potentially useful for predictive toxicity modeling. These new characteristics of molecular bioactivity arising from short-term biological assays, i.e., in vitro screening and/or in vivo toxicogenomics data can now be exploited in combination with chemical structural information to generate hybrid QSAR–like quantitative models to predict human toxicity and carcinogenicity. Using several case studies, we illustrate the benefits of a hybrid modeling approach, namely improvements in the accuracy of models, enhanced interpretation of the most predictive features, and expanded applicability domain for wider chemical space coverage.