cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis.
Creators: name: Kuethe, Friedhelm
name: Lindner, Juha
name: Matschke, Klaus
name: Wenzel, Juergen J.
name: Norja, Päivi
name: Ploetze, Katrin
name: Schaal, Sarah
name: Kamvissi, Virginia
name: Bornstein, Stefan R.
name: Schwanebeck, Uta
name: Modrow, Susanne
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: 500 Naturwissenschaften
subject: Aged
subject: Antibodies, Viral/immunology
subject: Capsid Proteins/immunology
subject: Cardiomyopathy, Dilated
subject: DNA, Viral/genetics
subject: Enzyme-Linked Immunosorbent Assay
subject: Female
subject: Genotype
subject: Heart/virology
subject: Human bocavirus/immunology
subject: Humans
subject: Male
subject: Middle Aged
subject: Myocarditis
subject: Parvoviridae Infections/virology
subject: Parvovirus B19, Human/immunology
subject: Polymerase Chain Reaction
subject: Prevalence

description: BACKGROUND: Although the DNA of parvovirus B19 (B19V) is frequently detected in patients with dilated cardiomyopathy or myocarditis, whether the parvovirus causes disease is questionable, since even in healthy individuals the virus persists in various tissues. The same question applies to human bocavirus (HBoV). We have determined the prevalence and quantity of B19V and HBoV DNA in heart tissue of patients who were not experiencing virus-related heart diseases and analyzed whether the seroprevalence corresponded to DNA prevalence in the heart. METHODS: Samples of left-atrium heart tissue and serum were obtained from 100 patients who underwent open-heart surgery. Serum immunoglobulin (Ig) G and IgM against proteins encoded by B19V and HBoV were detected by enzyme-linked immunoabsorption assay and immunoblotting. B19V and HBoV DNA concentrations were determined by quantitative real-time polymerase chain reaction (PCR) in heart tissue and serum samples. Nested PCRs for VP1, K71, and GT3 identified the B19V genotypes. RESULTS: The prevalences of serum IgG specific for B19V and HBoV were 85% and 96%, respectively. Of all the patients, 85% had B19V DNA detected in heart tissues, and 4% displayed low-level B19V viremia, whereas only 5% of heart tissue samples and none of the serum samples demonstrated HBoV DNA. The sensitivity of B19V serological testing for B19V DNA in heart samples was 0.96 (95% confidence interval, 0.92-1.0). Specificity was 0.8 (95% confidence interval, 0.6-1.0), and the positive predictive value was 0.96 (95% confidence interval, 0.92-1.0). B19V genotypes 1 and 2 were present in 11% and 89% of heart tissues samples, respectively. B19V genotype 3 was not detected in any of the samples. CONCLUSIONS: Our data suggest that B19V but not HBoV demonstrates a lifelong persistence in the heart. The detection of B19V DNA in heart tissue showed no correlation with clinical symptoms. We strongly recommend that serological testing become a standardized procedure for future studies, to obtain representative data concerning the prevalence of B19V in the heart.
Continuous and Discrete Symmetries of Renormalization Group Equations for Neutrino Oscillations in Matter
Creators: name: Zhou, Shun
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Three-flavor neutrino oscillations in matter can be described by three effective neutrino masses $\widetilde{m}^{}_i$ (for $i = 1, 2, 3$) and the effective mixing matrix $V^{}_{αi}$ (for $α= e, μ, τ$ and $i = 1, 2, 3$). When the matter parameter $a \equiv 2\sqrt{2} G^{}_{\rm F} N^{}_e E$ is taken as an independent variable, a complete set of first-order ordinary differential equations for $\widetilde{m}^2_i$ and $|V^{}_{αi}|^2$ have been derived in the previous works. In the present paper, we point out that such a system of differential equations possesses both the continuous symmetries characterized by one-parameter Lie groups and the discrete symmetry associated with the permutations of three neutrino mass eigenstates. The implications of these symmetries for solving the differential equations and looking for differential invariants are discussed.
description: 24 pages, no figures, typos corrected, more discussions added, to be published in J. Phys. G
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future
Creators: name: Stueven, Anna Kathrin
name: Kayser, Antonin
name: Wetz, Christoph
name: Amthauer, Holger
name: Wree, Alexander
name: Tacke, Frank
name: Wiedenmann, Bertram
name: Roderburg, Christoph
name: Jann, Henning
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: neuroendocrine tumor
subject: carcinoid
subject: somatostatin analogue
subject: octreotide
subject: lanreotide
subject: PROMID
subject: CLARINET
subject: PRRT
subject: NETTER-1
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no longer available. Prognosis and survival of patients with NETs are determined by the location of the primary lesion, biochemical functional status, differentiation, initial staging, and response to treatment. Somatostatin analogue (SSA) therapy has been a mainstay of antisecretory therapy in functioning neuroendocrine tumors, which cause various clinical symptoms depending on hormonal hypersecretion. Beyond symptomatic management, recent research demonstrates that SSAs exert antiproliferative effects and inhibit tumor growth via the somatostatin receptor 2 (SSTR2). Both the PROMID (placebo-controlled, prospective, randomized study in patients with metastatic neuroendocrine midgut tumors) and the CLARINET (controlled study of lanreotide antiproliferative response in neuroendocrine tumors) trial showed a statistically significant prolongation of time to progression/progression-free survival (TTP/PFS) upon SSA treatment, compared to placebo. Moreover, the combination of SSA with peptide receptor radionuclide therapy (PRRT) in small intestinal NETs has proven efficacy in the phase 3 neuroendocrine tumours therapy (NETTER 1) trial. PRRT is currently being tested for enteropancreatic NETs versus everolimus in the COMPETE trial, and the potential of SSTR-antagonists in PRRT is now being evaluated in early phase I/II clinical trials. This review provides a synopsis on the pharmacological development of SSAs and their use as antisecretory drugs. Moreover, this review highlights the clinical evidence of SSAs in monotherapy, and in combination with other treatment modalities, as applied to the antiproliferative management of neuroendocrine tumors with special attention to recent high-quality phase III trials.
Multifrequency JVLA observations of the X-shaped radio galaxy in Abell 3670
Creators: name: Bruno, Luca
name: Gitti, Myriam
name: Zanichelli, Alessandra
name: Gregorini, Loretta
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context. X-shaped radio galaxies (XRGs) exhibit a pair of bright primary lobes and a pair of weak secondary lobes (wings), which are oriented with an angle that gives the structure a cross-like shape. Though several theoretical models have been proposed to explain their origin, there is currently not a general consensus on a formation scenario. Aims. We analysed new multifrequency Karl G. Jansky Very Large Array (JVLA) radio data at 1.5, 5.5, 6, and 9 GHz of the candidate XRG in Abell 3670 (A3670) in order to characterise and classify it for the first time and to investigate its origin. Methods. We produced flux, spectral index, and radiative age maps of A3670 by means of the new radio data. We investigated the connection between the radio galaxy and its host, a brightest cluster galaxy (BCG) with two optical nuclei classified as a dumbbell galaxy. Finally we discussed the literature models and compared them to the observed properties of A3670. Results. We classify A3670 as a Fanaroff-Riley I-type XRG and measured a 1.4 GHz radio power of 1.7 x 10^25 W Hz-1. By estimating the radiative age of the various source components, we find that the wings are 20 Myr older than the lobes. We verified that the lobes and wings are aligned with the major and minor axes of the optical galaxy, respectively, and we estimated a black hole mass of 10^9 Msun , which is in agreement with the typical properties of the XRGs. Conclusions. Among the discussed scenarios, the jet-shell interaction model may best reproduce the observed properties of A3670. The gas of a stellar shell is responsible for the deflection of the jets, thus forming the wings. The presence of stellar shells in A3670 is plausible, but it needs further optical observations to be confirmed.
description: 11 pages, 19 figures grouped in 8, in press on Astronomy&Astrophysics
On 4-fold covering moves
Creators: name: Apostolakis, Nikos
Publisher: name: arXiv
Year: 2003
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M12, 57M25

description: We prove the existence of a finite set of moves sufficient to relate any two representations of the same 3-manifold as a 4-fold simple branched covering of S^3. We also prove a stabilization result: after adding a fifth trivial sheet two local moves suffice. These results are analogous to results of Piergallini in degree 3 and can be viewed as a second step in a program to establish similar results for arbitrary degree coverings of S^3.
description: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol3/agt-3-5.abs.html Version 2: correction added on page 138
Investigation of the mucoadhesivity, swelling and drug release mechanisms of indomethacin buccal tablets: effect of formulation variables
Creators: name: Ozgur Esim
name: Savaser, Ayhan
name: Ozkan, Cansel Kose
name: Cetin Tas
name: Yalcın Ozkan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: The purpose of this study was to investigate the effect of formulation variables on properties related to critical functionality for their use in indomethacin buccal tablets. Chitosan (CH), carbopol (PAA) and hydroxypropyl methyl cellulose (HPMC) concentration and filler type were evaluated as parameters for describing tablet hardness, swelling index, indomethacin release and mucoadhesion in controlled release buccal tablets. Moreover, a 32 full factorial design was employed to study the effect of each polymer ratios in CH and PAA combination, which significantly influenced characteristics. A slower indomethacin release and a considerably larger degree of swelling were found for different concentrations of PAA or CH (P In vitro drug release in simulated saliva (pH 6.75) appears to occur both by diffusion and a swelling-controlled mechanism, exhibiting anomalous, Case II type transport or Super Case II type transport. The diluent present in all study samples, mannitol (MAN), spray dried lactose (SDL) and microcrystalline cellulose (MC) were believed to contribute minimally to hydrogel formation and drug release regulation. The dissolution values for the three co-excipients were a decreasing order mannitol, spray dried lactose and microcrystalline cellulose. In conclusion, the type and concentration of all polymers seem to change the functionality of buccal tablets and it seems important to understand and characterize these excipients to fully predict the drug release, mucoadhesion and swelling of buccal tablets.
Hybrid Imaging in Head and Neck Sarcoidosis
Creators: name: Grozdic Milojevic, Isidora
name: Tadic, Marijana
name: Sobic-Saranovic, Dragana
name: Saponjski, Jelena
name: Artiko, Vera M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: FDG PET/CT
subject: chronic sarcoidosis
subject: head and neck sarcoidosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: To determine the prevalence of head and neck sarcoidosis (HNS) and evaluate the role of hybrid molecular imaging in HNS. Between 2010 and 2018, 222 patients with chronic sarcoidosis and presence of prolonged symptoms of active disease were referred to FDG PET/CT. Active disease was found in 169 patients, and they were all screened for the presence of HNS. All patients underwent MDCT and assessment of the serum ACE level. Follow-up FDG PET/CT examination was done 19.84 ± 8.98 months after the baseline. HNS was present in 38 out of 169 patients. FDG uptake was present in: cervical lymph nodes (38/38), submandibular glands (2/38), cerebrum (2/38), and bone (1/38). The majority of patients had more than two locations of disease. After FDG PET/CT examination, therapy was changed in most patients. Fourteen patients returned to follow-up FDG PET/CT examination in order to assess the therapy response. PET/CT revealed active disease in 12 patients and complete remission in two patients. Follow-up ACE levels had no correlation with follow-up SUVmax level (ρ = −0.18, p = 0.77). FDG PET/CT can be useful in the detection of HNS and in the evaluation of the therapy response. It may replace the use of non-purposive mounds of insufficiently informative laboratory and radiological procedures.
Helluodes taprobanae Westwood 1847
Creators: name: Sabu, Thomas K.
name: Abhitha, Prabhakar
name: Zhao, Danyang
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Helluodes
Helluodes taprobanae

description: Helluodes taprobanae Westwood, 1847
(Figs. 9–11)
 Helluodes taprobanae Westwood, 1847: 279; Chaudoir, 1862: 302.
 Head. Labrum large, as wide as long, anterior angles rounded, apex between angles slightly emarginate. Maxillary palpomere 4 roundly dilate from middle to apex, inflexed medially and medial surface with distinct, deep puncture, roundly narrowed at apex. Ligula elongate, narrow and tapering towards apex with two elongate apical setae.
 Pronotum. Apical angles projected and rounded; surface densely punctate and pubescent; anterior and posterior transverse sulci shallow; lateral margin explanate and reflexed; posterior angles weakly reflexed and blunt at apex; basal foveae deep and wide, extended forward as deep lateral furrows; lateral margins weakly sinuate anterior to posterior angles; base distinctly oblique laterally, narrower than apex.
 Elytra. Apices obliquely truncate with wide membranous margins; intervals densely pubescent and punctuated; lateral edges narrow.
 Venter. Sternites 3 to 4 in male with one pair of paramedian setae
 Measurements. Male (n=1), TLA = 24.5; TLB = 19.5; TW = 7.0; PL = 3.2; PW = 5.5; EL = 12.0.
 Specimens examined (n=1). Lectotype male, labeled “ Ex-Musaeo Chaudoir ” / “ Taprobanae Westwoodi, Ceylan, Nietner ” at MNHN Paris.
 Distribution. Sri Lanka (Kandy, Kitugalle, Kotte, Matale, Galgamuwa, Peradeniya-Sri Lanka Lowland rainforest ecoregion)
 Remarks. With slightly emarginate margin between anterior angles of labrum, rounded anterior angles of pronotum and slender ligula, H. taprobanae is more similar to H. devagiriensis n.sp., but differs from the latter in the absence of dentation on the anterior margin of labrum, maxillary palpomere 4 roundly dilated from middle to apex and roundly narrowed at apex, and in more densely punctuate pronotal disc. Although females of H. taprobanae are not known, we predict that the venter of the female will not have paramedial setae on segments 3 and 4 and that this will be a sexually dimorphic character similar to that found in all species of the genus Helluodes and tribe Physocrotaphini examined to date.
description: Published as part of Sabu, Thomas K., Abhitha, Prabhakar & Zhao, Danyang, 2008, A new Helluodes Westwood species from Western Ghats with notes on habitat, distribution and phylogenetic relationships of genera Helluodes Westwood and Physocrotaphus Parry of the tribe Physocrotaphini Chaudoir (Insecta: Coleoptera: Carabidae: Anthiinae), pp. 30-46 in Zootaxa 1745 (1) on page 36, DOI: 10.11646/zootaxa.1745.1.3, http://zenodo.org/record/5108342
Yttrium Tantalum Oxynitride Multiphases as Photoanodes for Water Oxidation
Creators: name: Si, Wenping
name: Tehrani, Zahra Pourmand
name: Haydous, Fatima
name: Marzari, Nicola
name: Castelli, Ivano E.
name: Pergolesi, Daniele
name: Lippert, Thomas
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Perovskite yttrium tantalum oxynitride is theoretically proposed as a promising semiconductor for solar water splitting because of the predicted bandgap and energy positions of band edges. In experiment, however, we show here that depending on processing parameters, yttrium tantalum oxynitrides exist in multiphases, including the desired perovskite YTaON2, defect fluorite YTa(O,N,o)4, and N-doped YTaO4. These multiphases have bandgaps ranging between 2.13 and 2.31 eV, all responsive to visible light. The N-doped YTaO4, perovskite main phase, and fluorite main phase derived from crystalline fergusonite oxide precursors exhibit interesting photoelectrochemical performances for water oxidation, while the defect fluorite derived from low crystallized scheelite-type oxide precursors show negligible activity. Preliminarily measurements show that loading IrOx cocatalyst on N-doped YTaO4 significantly improves its photoelectrochemical performance encouraging further studies to optimize this new material for solar fuel production.
X-ray Point Sources in the Sombrero Galaxy: Supersoft sources, the globular cluster/LMXB connection, and an overview
Creators: name: Di Stefano, R.
name: Kong, A. K. H.
name: VanDalfsen, M. L.
name: Harris, W. E.
name: Murray, S. S.
name: Delain, K. M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on the population of point sources discovered during an 18.5 ksec Chandra ACIS-S observation of the Sombrero Galaxy. We present the luminosity function, the spectra of the 6 brightest sources, consider correlations with globular clusters (GCs) and with planetary nebulae (PNe), and study the galaxy's population of SSSs. We detected 122 sources, 22 of them are identified as luminous supersoft X-ray sources (SSSs). There is an over density of SSSs within 1.5 kpc of the nucleus, which is itself the brightest X-ray source. SSSs are also found in the disk and halo, with 1 SSS in a globular cluster (GC). Several sources in Sombrero's halo are good candidates for SSS models in which the accretor is a nuclear-burning white dwarf. In total, 32 X-ray sources are associated with GCs. The majority of sources with luminosity > 1e38 erg/s are in GCs. These results for M104, an Sa galaxy, are similar to what has been found for elliptical galaxies and for the late-type spiral M31. We find that those optically bright GCs with X-ray sources house only the brightest X-ray sources. We find that, in common with other galaxies, there appears to be a positive connection between young (metal-rich) GCs and X-ray sources, but that the brightest X-ray sources are equally likely to be in metal-poor GCs. We propose a model which can explain the trends seen in the data sets from the Sombrero and other galaxies. Thermal-time scale mass transfer can occur in some of the the younger clusters in which the turn-off mass is slightly greater than $0.8 M_\odot$; multiplicity may play a role in some of the most massive clusters; accretion from giant stars may be the dominant mechanism in some older, less massive and less centrally concentrated clusters.
description: 13 pages, 7 figures. ApJ submitted
Heavy-light mesons beyond ladder approximation
Creators: name: Qin, Pianpian
name: Qin, Si-xue
name: Liu, Yu-xin
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The heavy-light mesons are studied within the framework of Dyson-Schwinger equations of QCD. Inspired by the axial-vector Ward-Takahashi identity resulting from the chiral symmetry, we propose a truncation scheme beyond the ladder approximation without introducing any additional parameter. For the pseudoscalar and vector heavy-light mesons, the obtained mass spectrum has the level of relative errors at $5\%$ compared with experimental data and lattice-QCD results. For the leptonic decay constants, our results are comparable with those from experiments and/or lattice QCD. For some channels, the discrepancies are sizable but significantly smaller than those using the equal spacing rule. The truncation scheme proposed in this work is simple and could be improved and applied to study other open flavor hadrons including both mesons and baryons.
description: 9 pages, 6 figures, and 4 tables
Toward simplified oral lipid-based drug delivery using mono-/di-glycerides as single component excipients
Creators: name: Alexandra-Roxana Ilie
name: Griffin, Brendan T.
name: Vertzoni, Maria
name: Kuentz, Martin
name: Cuyckens, Filip
name: Wuyts, Koen
name: Ruzica Kolakovic
name: Holm, René
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: This study aimed to systematically explore compositional effects for a series of lipid systems, on the in vitro drug solubilization and in vivo bioavailability of three poorly water-soluble drugs with different physico-chemical properties. While many lipid-based drug products have successfully reached the market, there is still a level of uncertainty on the design guidelines for such drug products with limited understanding on the influence of composition on in vitro and in vivo performance. Lipid-based drug delivery systems were prepared using either single excipient systems based on partially digested triglycerides (i.e. mono- and/or di-glycerides) or increasingly complex systems by incorporating surfactants and/or triglycerides. These lipid systems were evaluated for both in vitro and in vivo behavior. Results indicated that simple single component long chain lipid systems are more beneficial for the absorption of the weak acid celecoxib and the weak base cinnarizine compared to equivalent single component medium chain lipid systems. Similarly, a two-component system produced by incorporating small amount of hydrophilic surfactant yields similar overall pharmacokinetic effects. The lipid drug delivery systems based on medium chain lipid excipients improved the in vivo exposure of the neutral drug JNJ-2A. The higher in vivo bioavailability of long chain lipid systems compared to medium chain lipid systems was in agreement with in vitro dilution and dispersion studies for celecoxib and cinnarizine. The present study demonstrated the benefits of using mono-/di-glycerides as single component excipients in LBDDS to streamline formulation screening and improve oral bioavailability for the three tested poorly water-soluble drugs.
REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder
Creators: name: Repantis, Dimitris
name: Wermuth, Katharina
name: Tsamitros, Nikolaos
name: Danker-Hopfe, Heidi
name: Bublitz, Jan Christoph
name: Kühn, Simone
name: Dresler, Martin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Acute stress disorder
subject: REM sleep
subject: REM sleep suppression
subject: polysomnography
subject: posttraumatic stress disorder
subject: secondary prevention
subject: sleep deprivation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Increasing evidence supports a close link between REM sleep and the consolidation of emotionally toned memories such as traumatic experiences. In order to investigate the role of sleep for the development of symptoms related to traumatic experiences, beyond experimental models in the laboratory, sleep of acutely traumatised individuals may be examined on the first night after trauma. This might allow us to identify EEG variables predicting the development of posttraumatic stress disorder (PTSD) symptoms, and guide the way to novel sleep interventions to prevent PTSD. Based on our experience, patients' acceptance of polysomnography in the first hours after treatment in an emergency room poses obstacles to such a strategy. Wearable, self-applicable sleep recorders might be an option for the investigation of sleep in the aftermath of trauma. They would considerably decrease the perceived burden for patients and thus increase the likelihood of successful patient recruitment. As one potential sleep intervention, sleep deprivation directly after trauma has been suggested to reduce the consolidation of traumatic memories and hence act as a secondary preventive measure. However, experimental data from sleep deprivation studies in healthy volunteers with the trauma film paradigm have been inconclusive regarding the beneficial or detrimental effects of sleep on traumatic memory processing. Depending on further insights into the role of sleep in traumatic memory consolidation through observational and experimental studies, several options for therapeutic sleep interventions are conceivable: besides behavioural sleep deprivation, selective REM sleep suppression or enhancement by a pharmacological intervention into the serotonergic, noradrenergic or cholinergic systems might provide novel therapeutic options. While REM-modulating drugs have been used with some success for the prevention of PTSD after trauma, they have never been tried before the first night of sleep. In conclusion, more experimental and observational research is needed before sleep interventions are performed in actual trauma victims
A 30 W, sub-kHz frequency-locked laser at 532 nm
Creators: name: Chen, Hao-Ze
name: Liu, Xiang-Pei
name: Wang, Xiao-Qiong
name: Wu, Yu-Ping
name: Wang, Yu-Xuan
name: Yao, Xing-Can
name: Chen, Yu-Ao
name: Pan, Jian-Wei
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on the realization of a high-power, ultranarrow-linewidth, and frequency-locked 532~nm laser system. The laser system consists of single-pass and intra-cavity second harmonic generation of a continuous-wave Ytterbium doped fiber laser at 1064~nm in the nonlinear crystal of periodically poled lithium niobate and lithium triborate, respectively. With 47~W infrared input, 30~W green laser is generated through the type I critical phase matching in the intracavity lithium triborate crystal. The laser linewidth is measured to be on the order of sub-kHz, which is achieved by simultaneously locking the single-pass frequency doubling output onto the iodine absorption line R69 (36-1) at 532~nm. Furthermore, the phase locking between the laser system and another slave 1064~nm laser is demonstrated with relative frequency tunability being up to 10~GHz. Our results completely satisfy the requirements of 532~nm laser for quantum simulation with ultracold atoms.
Lemborexant: First Approval
Creators: name: Scott, Lesley J.
Publisher: name: Adis Journals
Year: 2020
Subjects: Medicine

description: Compliance with Ethical Standards Funding The preparation of this review was not supported by any external funding. Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Lesley Scott is a salaried employee of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest.
Additional information about this Adis Drug Review can be found here

AbstractLemborexant (DAYVIGO™) is an orally administered, small molecule, competitive orexin receptor subtypes 1 and 2 antagonist is being developed by Eisai Inc. for the treatment of adult patients with insomnia and for adults with irregular sleep-wake rhythm disorder (ISWRD) associated with mild to moderate Alzheimer’s disease. In December 2019, lemborexant received its first global approval in the USA for the treatment of adult patients with insomnia, characterized by difficulties with sleep onset and/or maintenance. This article summarizes the milestones in the development of lemborexant leading to its first global approval for the treatment of adult patients with insomnia, characterized by difficulties with sleep onset and/or maintenance.© Springer Nature Switzerland AG 2020
Evolution of a Subsumption Architecture Neurocontroller
Creators: name: Togelius, Julian
Publisher: name: arXiv
Year: 2004
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences
subject: I.2.9; I.2.6

description: An approach to robotics called layered evolution and merging features from the subsumption architecture into evolutionary robotics is presented, and its advantages are discussed. This approach is used to construct a layered controller for a simulated robot that learns which light source to approach in an environment with obstacles. The evolvability and performance of layered evolution on this task is compared to (standard) monolithic evolution, incremental and modularised evolution. To corroborate the hypothesis that a layered controller performs at least as well as an integrated one, the evolved layers are merged back into a single network. On the grounds of the test results, it is argued that layered evolution provides a superior approach for many tasks, and it is suggested that this approach may be the key to scaling up evolutionary robotics.
Robust freeze-drying process re-design of a legacy product based on risk analysis and design of experiments
Creators: name: Clua-Palau, Gloria
name: Jo, Enric
name: Nikolic, Sasha
name: Coello, Jordi
name: Maspoch, Santiago
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: In this study, a QbD freeze-drying process re-design applied to a lyophilized injectable drug product is presented. The main objective was to assess the freeze-drying process robustness using a risk analysis and a proper experimental design. First, product’s thermal fingerprint was characterized by thermal analysis and freeze-drying microscopy. Then, according to the output of the risk analysis, primary drying temperature and pressure were studied by a Doehlert DoE design with four responses; primary drying time, appearance, residual moisture content and reconstitution time. Statistically significant MLR models were obtained for residual moisture content and primary drying time. In the latter, the temperature factor was the predominant factor to predict the duration of the primary drying stage. Two additional lab-scale batches were run to confirm the mathematical model predictions. Finally, optimal primary drying conditions (30 °C, 0.400mbar) were selected to minimize the duration of the primary drying stage, while preserving the quality of the product. It was possible to set high temperature and pressure values because no collapse temperature was found during the thermal characterization of the product. Secondary drying temperature and time were defined based on the residual moisture content results. It was shown that secondary drying is robust between 30 °C and 50 °C and from 3 h to 16 h. In conclusion, we were able to define a robust freeze-drying process which was further validated at industrial scale with satisfactory results and approved by the health authorities in different countries around Europe.
Vasodilation of Tea Polyphenols Ex Vivo Is Mediated by Hydrogen Peroxide Under Rapid Compound Decay
Creators: name: Lorenz, Mario
name: Lehmann, Stephanie
name: Djordjevic, Ilija
name: Düsterhöft, Thomas
name: Zimmermann, Benno F.
name: Stangl, Karl
name: Stangl, Verena
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: EGCG
subject: theaflavin
subject: polyphenols
subject: green tea
subject: black tea
subject: vasodilation
subject: ROS
subject: hydrogen peroxide
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Improvement of endothelial function represents a major health effect of tea in humans. Ex vivo, tea and tea polyphenols stimulate nitric oxide (NO)-dependent vasodilation in isolated blood vessels. However, it was reported that polyphenols can generate reactive oxygen species (ROS) in vitro. We therefore aimed to elucidate the role of ROS production in tea polyphenol-induced vasodilation in explanted aortic rings. Vasorelaxation of rat aortic rings was assessed in an organ chamber model with low concentrations of epigallocatechin-3-gallate (EGCG), theaflavin-3,3'-digallate (TF3), and with green and black tea, with or without pretreatment with catalase or superoxide dismutase (SOD). The stability of EGCG and TF3 was measured by HPLC, and the levels of hydrogen peroxide (H2O2) were determined. EGCG and green tea-induced vasorelaxation was completely prevented by catalase and slightly increased by SOD. TF3 and black tea yielded similar results. Both EGCG and TF3 were rapidly degraded. This was associated with increasing H2O2 levels over time. Hydrogen peroxide concentrations produced in a time range compatible with tea polyphenol decay induced NO-dependent vasodilation in aortic rings. In conclusion, tea polyphenol-induced vasodilation in vitro is mediated by low levels of H2O2 generated during compound decay. The results could explain the apparent lack of vasodilatory effects of isolated tea polyphenols in humans.
On the 3D dynamics and morphology of inner rings
Creators: name: Patsis, P. A.
name: Skokos, Ch.
name: Athanassoula, E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We argue that inner rings in barred spiral galaxies are associated with specific 2D and 3D families of periodic orbits located just beyond the end of the bar. These are families located between the inner radial ultraharmonic 4:1 resonance and corotation. They are found in the upper part of a type-2 gap of the x1 characteristic, and can account for the observed ring morphologies without any help from families of the x1-tree. Due to the evolution of the stability of all these families, the ring shapes that are favored are mainly ovals, as well as polygons with `corners' on the minor axis, on the sides of the bar. On the other hand pentagonal rings, or rings of the NGC 7020 type hexagon, should be less probable. The orbits that make the rings belong in their vast majority to 3D families of periodic orbits and orbits trapped around them.
description: 11 pages, 12 figures, to appear in MNRAS
Deuterosminthurus pallipes sensu Nayrolles 1996
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Bourletiellidae
Deuterosminthurus
Deuterosminthurus pallipes

description: Deuterosminthurus pallipes (Bourlet, 1841) sensu Nayrolles 1996 *
Sminthurus pallipes Bourlet, 1841: XLI.
Deuterosminthurus pallipes – Nayrolles 1996: 536, 546.
DISTRIBUTION. — France. Bourlet 1841; Gervais 1844; Nicolet 1847.
Aveyron. Gages au Causse Comtal, 620 m, vers Montrozier etroute entre Lioujas et Concourès, 600 m (Nayrolles 1996).
Côte-d’Or. Fontaines-les-Dijon (Denis 1924d, D. repandus).
Hautes-Pyrénées. Valléed’Aure (Cassagnau 1964a, c).
Hérault. Vignesdel’écoled’Agriculturede Montpellier (Denis 1924d).
Indre. Parc régional de la Brenne (Ponge et al. 2008).
Meurthe-et-Moselle. Picard 1962 (D. repanda).
Norddela France. Finot 1890.
Pyrénées-Orientales. Prèsde Banyuls-sur-Mer (Coineau & Delamare Deboutteville 1961, D. beckeri). — Route entre Saint-Paulde-Fenouillet et Ansignan (Nayrolles 1996).
TAXONOMIE. — Nayrolles 1996 (redescription).
ÉCOLOGIE. — Picard 1962 (faune psammique); Cassagnau 1964c; Ponge et al. 2008 (test perturbation environnement).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 400, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Migraine, headache, and mortality in women: a cohort study
Creators: name: Rohmann, Jessica Lee
name: Rist, Pamela Marie
name: Buring, Julie Elizabeth
name: Kurth, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Migraine
subject: Headache
subject: Mortality
subject: Women
subject: Epidemiology
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Migraine carries a high global burden, disproportionately affects women, and has been implicated as a risk factor for cardiovascular disease. Migraine with aura has been consistently associated with increased risk of cardiovascular mortality. However, published evidence on relationships between migraine or non-migraine headache and all-cause mortality is inconclusive. Therefore, we aimed to estimate the effect of non-migraine headache and migraine as well as migraine subtypes on all-cause and cause-specific mortality in women. Methods: In total, 27,844 Women’s Health Study participants, aged 45 years or older at baseline, were followed up for a median of 22.7 years. We included participants who provided information on migraine (past history, migraine without aura, or migraine with aura) or headache status and a blood sample at study start. An endpoints committee of physicians evaluated reports of incident deaths and used medical records to confirm deaths due to cardiovascular, cancer, or female-specific cancer causes. We used multivariable Cox proportional hazards models to estimate the effect of migraine or headache status on both all-cause and cause-specific mortality. Results: Compared to individuals without any headache, no differences in all-cause mortality for individuals suffering from non-migraine headache or any migraine were observed after adjustment for confounding (HR = 1.01, 95%CI, 0.93–1.10 and HR = 0.96, 95% CI: 0.89–1.04). No differences were observed for the migraine subtypes and all-cause death. Women having the migraine with aura subtype had a higher mortality due to cardiovascular disease (adjusted HR = 1.64, 95%CI: 1.06–2.54). As an explanation for the lack of overall association with all-cause mortality, we observed slightly protective signals for any cancer and female-specific cancers in this group. Conclusions: In this large prospective study of women, we found no association between non-migraine headache or migraine and all-cause mortality. Women suffering from migraine with aura had an increased risk of cardiovascular death. Future studies should investigate the reasons for the increased risk of cardiovascular mortality and evaluate whether changes in migraine patterns across the life course have differential effects on mortality.
Physocrotaphus Parry 1849
Creators: name: Sabu, Thomas K.
name: Abhitha, Prabhakar
name: Zhao, Danyang
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Physocrotaphus

description: Physocrotaphus Parry, 1849
Parry, 1849: 180–181; Lacordaire, 1854: 181–182; Chaudoir, 1862: 303.
 Color. Brownish black.
 Head. Narrower than prothorax; frontal foveae deeply depressed. Genae sparsely setose with group six or seven setae. Labrum subrectangular, anterior angles rounded; anterior margin straight. Maxillary palps with palpomere 2 longest; palpomere 4 longer than 3 rd. Mentum with bifid median tooth; lateral lobes of with a sharp tooth at apex. Ligula short and truncate anteriorly; paraglossae distinctly longer than ligula.
 Pronotum. Large, widest at anterior third with distinctly explanate lateral borders; apical margin straight; pronotal base narrower than apex, basal margin sinuate medially; anterior transverse sulcus obsolete; posterior transverse sulcus distinct.
 Elytra. Lateral margins faintly subserrate; apices strongly sinuate near outer angles.
 Venter. Abdominal sternite 3 of male with single circular, median depression and patch of long filamentous setae; sternites 3 to 5 in male and female with one pair of paramedian setae.
 Genitalia. Female stylomere 1 triangular, without setae at apical rim; stylomere 2 with two very small ensiform setae along medial margin and one umbilicate seta in middle of outer margin. Male aedeagus well sclerotised; median lobe with a dorsal opening; apex narrow, tapered, and rounded.
 Type species. Physocrotaphus ceylonicus Parry
 Geographic distribution. Sri Lanka (Dikoya-Sri Lankan montane evergreen forests).
description: Published as part of Sabu, Thomas K., Abhitha, Prabhakar & Zhao, Danyang, 2008, A new Helluodes Westwood species from Western Ghats with notes on habitat, distribution and phylogenetic relationships of genera Helluodes Westwood and Physocrotaphus Parry of the tribe Physocrotaphini Chaudoir (Insecta: Coleoptera: Carabidae: Anthiinae), pp. 30-46 in Zootaxa 1745 (1) on page 39, DOI: 10.11646/zootaxa.1745.1.3, http://zenodo.org/record/5108342
3-D Printed Protective Equipment during COVID-19 Pandemic
Creators: name: Wesemann, Christian
name: Pieralli, Stefano
name: Fretwurst, Tobias
name: Nold, Julian
name: Nelson, Katja
name: Schmelzeisen, Rainer
name: Hellwig, Elmar
name: Spies, Benedikt Christopher
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: 3-D printing
subject: COVID-19
subject: personal protective equipment
subject: face shield
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: While the number of coronavirus cases from 2019 continues to grow, hospitals are reporting shortages of personal protective equipment (PPE) for frontline healthcare workers. Furthermore, PPE for the eyes and mouth, such as face shields, allow for additional protection when working with aerosols. 3-D printing enables the easy and rapid production of lightweight plastic frameworks based on open-source data. The practicality and clinical suitability of four face shields printed using a fused deposition modeling printer were examined. The weight, printing time, and required tools for assembly were evaluated. To assess the clinical suitability, each face shield was worn for one hour by 10 clinicians and rated using a visual analogue scale. The filament weight (21-42 g) and printing time (1:40-3:17 h) differed significantly between the four frames. Likewise, the fit, wearing comfort, space for additional PPE, and protection varied between the designs. For clinical suitability, a chosen design should allow sufficient space for goggles and N95 respirators as well as maximum coverage of the facial area. Consequently, two datasets are recommended. For the final selection of the ideal dataset to be used for printing, scalability and economic efficiency need to be carefully balanced with an acceptable degree of protection.
The Optical Gravitational Lensing Experiment. Additional Planetary and Low-Luminosity Object Transits from the OGLE 2001 and 2002 Observational Campaigns
Creators: name: Udalski, A.
name: Pietrzynski, G.
name: Szymanski, M.
name: Kubiak, M.
name: Zebrun, K.
name: Soszynski, I.
name: Szewczyk, O.
name: Wyrzykowski, L.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The photometric data collected by OGLE-III during the 2001 and 2002 observational campaigns aiming at detection of planetary or low-luminosity object transits were corrected for small scale systematic effects using the data pipeline by Kruszewski and Semeniuk and searched again for low amplitude transits. Sixteen new objects with small transiting companions, additional to previously found samples, were discovered. Most of them are small amplitude cases which remained undetected in the original data. Several new objects seem to be very promising candidates for systems containing substellar objects: extrasolar planets or brown dwarfs. Those include OGLE-TR-122, OGLE-TR-125, OGLE-TR-130, OGLE-TR-131 and a few others. Those objects are particularly worth spectroscopic follow-up observations for radial velocity measurements and mass determination. With well known photometric orbit only a few RV measurements should allow to confirm their actual status. All photometric data of presented objects are available to the astronomical community from the OGLE Internet archive.
description: 8 pages. Appendix in 'jpg' format. Minor changes. Full resolution pages of Appendix and photometric data presented in the paper are available from the OGLE Internet archive: See http://ogle.astrouw.edu.pl or its US mirror, at http://bulge.princeton.edu/~ogle
Deuterosminthurus sulphureus subsp. sulphureus sulphureus (Koch 1840
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Bourletiellidae
Deuterosminthurus
Deuterosminthurus sulphureus
Deuterosminthurus sulphureus sulphureus (koch, 1840)

description: Deuterosminthurus sulphureus sulphureus (Koch, 1840)
Smynthurus sulphureus Koch, 1840: 353.
Bourletiella (Deuterosminthurus) sulphura – Gisin 1946: 253.
Deuterosminthurus sulphureus sulphureus – Bretfeld 1999: 241.
DISTRIBUTION. — Ariège. Vers Ornolac-Ussat-les-Bains (Nayrolles 1996, D. mediterraneus).
Aveyron. Plateau de la Justice vers Bessuèjouls et Gages au Causse Comtal (Nayrolles 1996).
Haute-Garonne. Campusuniversitaire de Toulouse (Nayrolles 1996).
Hautes-Pyrénées. Valléed’Aure (Cassagnau 1964a, c).
Nièvre. Parcrégionaldu Morvan (Ponge etal. 2003).
Tarn, Aude. Montagne Noire (Cassagnau 1965).
TAXONOMIE. — Nayrolles 1996 (redescription).
ÉCOLOGIE. — Cassagnau 1964c, 1965 (écologie, sol); Ponge etal. 2003 (bioindicateur).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 400, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
Probabilistic Time of Arrival Localization
Creators: name: Perez-Cruz, Fernando
name: Olmos, Pablo M.
name: Zhang, Michael Minyi
name: Huang, Howard
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Signal Processing (eess.SP)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we take a new approach for time of arrival geo-localization. We show that the main sources of error in metropolitan areas are due to environmental imperfections that bias our solutions, and that we can rely on a probabilistic model to learn and compensate for them. The resulting localization error is validated using measurements from a live LTE cellular network to be less than 10 meters, representing an order-of-magnitude improvement.
description: IEEE Signal Processing Letters, 2019