cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
How do citizen scientists improve at counting from Fossil atmospheres: a case study of citizen science in question-driven palaeontological research
Creators: name: Soul, Laura C.
name: Barclay, Richard S.
name: Bolton, Amy
name: Wing, Scott L.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Plots of improvement by image counted for each individual user. The accuracy of each citizen scientist's stomatal index estimate, relative to the estimate of RSB, plotted as a ‘time series’ in the order in which they classified them, as a proxy for experience.
Boosting the Performance of Quantum Annealers using Machine Learning
Creators: name: Brence, Jure
name: Mihailović, Dragan
name: Kabanov, Viktor
name: Todorovski, Ljupčo
name: Džeroski, Sašo
name: Vodeb, Jaka
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Noisy intermediate-scale quantum (NISQ) devices are spearheading the second quantum revolution. Of these, quantum annealers are the only ones currently offering real world, commercial applications on as many as 5000 qubits. The size of problems that can be solved by quantum annealers is limited mainly by errors caused by environmental noise and intrinsic imperfections of the processor. We address the issue of intrinsic imperfections with a novel error correction approach, based on machine learning methods. Our approach adjusts the input Hamiltonian to maximize the probability of finding the solution. In our experiments, the proposed error correction method improved the performance of annealing by up to three orders of magnitude and enabled the solving of a previously intractable, maximally complex problem.
Advancing Renewable Energy Communities in Europe
Creators: name: Hinsch, Arthur
name: Di Nucci, Maria Rosaria
name: Krug, Michael
name: Rothballer, Cartsen
name: Russel, Lucy
Publisher: name: Zenodo
Year: 2023
Subjects: renewable energy communities, best practices, enabling frameworks, transposition of the Renewable Energy Directive

description: This publication presents in a compact, easy to read format some of the major outcomes of the COME RES project (H2020 Grant 9530040). It illustrates how the nine COME RES countries (BE, DE, IT, LV, NL PL, PT, LV, ES) can count on a wealth of experiences and innovative solutions at local and regional level and how elements of them can be easily adapted to other contexts and transferred elsewhere and thus contribute to a more resilient and inclusive energy system.
description: This publication presents in a compact, easy to read form some of the major outcomes of the COME RES project (H2020 GA 9530040). It illustrates how the nine COME RES countries (BE, DE, IT, LV, NL PL, PT, LV, ES) can count on a wealth of experiences and innovative solutions at local and regional level and how elements of them can be easily adapted to other contexts and transferred elsewhere and thus contribute to a more resilient and inclusive energy system.
The Small Subunit of the Mammalian Mitochondrial Ribosome: IDENTIFICATION OF THE FULL COMPLEMENT OF RIBOSOMAL PROTEINS PRESENT
Creators: name: Burkhart, William
name: Spremulli, Linda L.
name: Moseley, Arthur
name: Blackburn, Kevin
name: Koc, Emine Cavdar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Identification of all the protein components of the small subunit (28 S) of the mammalian mitochondrial ribosome has been achieved by carrying out proteolytic digestions of whole 28 S subunits followed by analysis of the resultant peptides by liquid chromatography and tandem mass spectrometry (LC/MS/MS). Peptide sequence information was used to search the human EST data bases and complete coding sequences of the proteins were assembled. The human mitochondrial ribosome has 29 distinct proteins in the small subunit. Fourteen of this group of proteins are homologs of the Escherichia coli 30 S ribosomal proteins S2, S5, S6, S7, S9, S10, S11, S12, S14, S15, S16, S17, S18, and S21. All of these proteins have homologs in Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae mitochondrial ribosomes. Surprisingly, three variants of ribosomal protein S18 are found in the mammalian and D. melanogaster mitochondrial ribosomes while C. elegans has two S18 homologs. The S18 homologs tend to be more closely related to chloroplast S18s than to prokaryotic S18s. No mitochondrial homologs to prokaryotic ribosomal proteins S1, S3, S4, S8, S13, S19, and S20 could be found in the peptides obtained from the whole 28 S subunit digests or by analysis of the available data bases. The remaining 15 proteins present in mammalian mitochondrial 28 S subunits (MRP-S22 through MRP-S36) are specific to mitochondrial ribosomes. Proteins in this group have no apparent homologs in bacterial, chloroplast, archaebacterial, or cytosolic ribosomes. All but two of these proteins have a clear homolog in D. melanogaster while all but three can be found in the genome of C. elegans. Five of the mitochondrial specific ribosomal proteins have homologs in S. cerevisiae.
N$_2$H: A Novel Polymeric Hydronitrogen as a High Energy Density Material
Creators: name: Yin, Ketao
name: Wang, Yanchao
name: Liu, Hanyu
name: Peng, Feng
name: Zhang, Lijun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The polymeric phase of nitrogen connected by the lower (than three) order N-N bonds has been long sought after for the potential application as high energy density materials. Here we report a hitherto unknown polymeric N$_2$H phase discovered in the high-pressure hydronitrogen system by first-principle structure search method based on particle swarm optimization algorithm. This polymeric hydronitrogen consists of quasi-one-dimensional infinite armchair-like polymeric N chains, where H atoms bond with two adjacent N located at one side of armchair edge. It is energetically stable against decomposition above ~33 GPa, and shows novel metallic feature as the result of pressure-enhanced charge transfer and delocalization of π electrons within the infinite nitrogen chains. The high energy density (~4.40 KJ/g), high nitrogen content (96.6%), as well as relatively low stabilization pressure, make it a possible candidate for high energy density applications. It also has lattice dynamical stability down to the ambient pressure, allowing for the possibility of kinetic stability with respect to variations of external conditions. Experimental synthesis of this novel phase is called for.
description: 7 pages, 8 figures + Supplementary information
Effective angle of attack from Aerodynamics of manoeuvring flight in brown long-eared bats (Plecotus auritus).
Creators: name: Henningsson, Per
name: Jakobsen, Lasse
name: Hedenström, Anders
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Effective angle of attack
One-loop conformal anomaly in an implicit momentum space regularization framework
Creators: name: Vieira, A. R.
name: Felipe, J. C. C.
name: Gazzola, G.
name: Sampaio, Marcos
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we consider matter fields in a gravitational background in order to compute the breaking of the conformal current at one-loop order. Standard perturbative calculations of conformal symmetry breaking expressed by the non-zero trace of the energy-momentum tensor have shown that some violating terms are regularization dependent, which may suggest the existence of spurious breaking terms in the anomaly. Therefore, we perform the calculation in a momentum space regularization framework in which regularization dependent terms are judiciously parametrized. We compare our results with those obtained in the literature and conclude that there is an unavoidable arbitrariness in the anomalous term $\Box R$.
description: in European Physical Journal C, 2015
Bat and prey trajectories from Aerodynamics of manoeuvring flight in brown long-eared bats (Plecotus auritus).
Creators: name: Henningsson, Per
name: Jakobsen, Lasse
name: Hedenström, Anders
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: 2D top-down view of bat and prey trajectories
(1769) Charlotte Anne Brown
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Thrombin Regulates Vascular Smooth Muscle Cell Growth and Heat Shock Proteins via the JAK-STAT Pathway
Creators: name: Patterson, Cam
name: Runge, Marschall S.
name: Li, Suzhen
name: Madamanchi, Nageswara R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The growth-stimulating effects of thrombin are mediated primarily via activation of a G protein-coupled receptor, PAR-1. Because PAR-1 has no intrinsic tyrosine kinase activity, yet requires tyrosine phosphorylation events to induce mitogenesis, we investigated the role of the Janus tyrosine kinases (JAKs) in thrombin-mediated signaling. JAK2 was activated rapidly in rat vascular smooth muscle cells (VSMC) treated with thrombin, and signal transducers and activators of transcription (STAT1 and STAT3) were phosphorylated and translocated to the nucleus in a JAK2-dependent manner. AG-490, a JAK2-specific inhibitor, and a dominant negative JAK2 mutant inhibited thrombin-induced ERK2 activity and VSMC proliferation suggesting that JAK2 is upstream of the Ras/Raf/MEK/ERK pathway. To elucidate the functional significance of JAK-STAT activation, we studied the effect of thrombin on heat shock protein (Hsp) expression, based upon the following: 1) reports that thrombin stimulates reactive oxygen species production in VSMC; 2) the putative role of Hsps in modulating cellular responses to reactive oxygen species; and 3) the presence of functional STAT1/3-binding sites in Hsp70 and Hsp90beta promoters. Indeed, thrombin up-regulated Hsp70 and Hsp90 protein expression via enhanced binding of STATs to cognate binding sites in the Hsp70 and Hsp90 promoters. Together, these results suggest that JAK-STAT pathway activation is necessary for thrombin-induced VSMC growth and Hsp gene expression.
(1770) James Browne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Search for anisotropic Lorentz invariance violation with γ-rays
Creators: name: Kislat, Fabian
name: Krawczynski, Henric
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: While Lorentz invariance, the fundamental symmetry of Einstein's theory of General Relativity, has been tested to a great level of detail, Grand Unified Theories that combine gravity with the other three fundamental forces may result in a violation of Lorentz symmetry at the Planck scale. These energies are unattainable experimentally. However, minute deviations from Lorentz invariance may still be present at much lower energies. These deviations can accumulate over large distances, making astrophysical measurements the most sensitive tests of Lorentz symmetry. One effect of Lorentz invariance violation is an energy dependent photon dispersion of the vacuum resulting in differences of the light travel time from distant objects. The Standard-Model Extension (SME) is an effective theory to describe the low-energy behavior of a more fundamental Grand Unified Theory, including Lorentz and CPT violating terms. In the SME the Lorentz violating operators can in part be classified by their mass-dimension d, with the lowest order being d=5. However, measurements of photon polarization have constrained operators with d=5 setting lower limits on the energy at which they become dominant well beyond the Planck scale. On the other hand, these operators also violate CPT, and thus d=6 could be the leading order. In this paper we present constraints on all 25 real coefficients describing anisotropic non-birefringent Lorentz invariance violation at mass dimension d=6 in the SME. We used Fermi-LAT observations of 25 active galactic nuclei to constrain photon dispersion and combined our results with previously published limits in order to simultaneously constrain all 25 coefficients. This represents the first set of constraints on these coefficients of a mass-dimension d=6, whereas previous measurements were only able to constrain linear combinations of all 25 coefficients.
description: 11 pages, 4 figures, Accepted for publication in Phys. Rev. D
Tissue Transglutaminase Facilitates the Polymerization of Insulin-like Growth Factor-binding Protein-1 (IGFBP-1) and Leads to Loss of IGFBP-1's Ability to Inhibit Insulin-like Growth Factor-I-stimulated Protein Synthesis
Creators: name: Clemmons, David R.
name: Busby Jr., Walker H.
name: Sakai, Keiji
name: Clarke, Jane B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Insulin-like growth factor-binding protein-1 (IGFBP-1) binds to insulin-like growth factors (IGFs) and has been shown to inhibit or stimulate cellular responses to IGF-I in vitro. This capacity of IGFBP-1 to inhibit or stimulate IGF-I actions correlates with its ability to form stable high molecular weight multimers. Since the ability of some proteins to polymerize is dependent upon transglutamination, we determined if tissue transglutaminase could catalyze this reaction and the effect of polymerization of IGFBP-1 upon IGF-I action. Following incubation with pure tissue transglutaminase (Tg), IGFBP-1 formed covalently linked multimers that were stable during SDS-polyacrylamide gel electrophoresis using reducing conditions. Dephosphorylated IGFBP-1 polymerized more rapidly and to a greater extent compared with native (phosphorylated) IGFBP-1. Exposure to IGF-I stimulated transglutamination of IGFBP-1 in vitro. An IGFBP-1 mutant in which Gln(66)-Gln(67) had been altered to Ala(66)-Ala(67) (Q66A/Q67A) was relatively resistant to polymerization by Tg compared with native IGFBP-1. Tg localized in fibroblast membranes was also shown to catalyze the formation of native IGFBP-1 multimers, however, Q66A/Q67A IGFBP-1 failed to polymerize. Although the mutant IGFBP-1 potently inhibited IGF-I stimulated protein synthesis in pSMC cultures, the same concentration of native IGFBP-1 had no inhibitory effect. The addition of higher concentrations of native IGFBP-1 did inhibit the protein synthesis response, and this degree of inhibition correlated with the amount of monomeric IGFBP-1 that was present. In conclusion, IGFBP-1 is a substrate for tissue transglutaminase and Tg leads to the formation of high molecular weight covalently linked multimers. Polymerization is an important post-translational modification of IGFBP-1 that regulates cellular responses to IGF-I.
Unique Pathway of Thrombin-induced Platelet Aggregation Mediated by Glycoprotein Ib
Creators: name: Foster, Carolyn
name: Lord, Susan T.
name: Class, Reiner
name: Marchese, Patrizia
name: Ruggeri, Zaverio M.
name: Morgan, Doris A.
name: Soslau, Gerald
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Thrombin plays a central role in normal and abnormal hemostatic processes. It is assumed that alpha-thrombin activates platelets by hydrolyzing the protease-activated receptor (PAR)-1, thereby exposing a new N-terminal sequence, a tethered ligand, which initiates a cascade of molecular reactions leading to thrombus formation. This process involves cross-linking of adjacent platelets mediated by the interaction of activated glycoprotein (GP) IIb/IIIa with distinct amino acid sequences, LGGAKQAGDV and/or RGD, at each end of dimeric fibrinogen molecules. We demonstrate here the existence of a second alpha-thrombin-induced platelet-activating pathway, dependent on GP Ib, which does not require hydrolysis of a substrate receptor, utilizes polymerizing fibrin instead of fibrinogen, and can be inhibited by the Fab fragment of the monoclonal antibody LJIb-10 bound to the GP Ib thrombin-binding site or by the cobra venom metalloproteinase, mocarhagin, that hydrolyzes the extracellular portion of GP Ib. This alternative alpha-thrombin pathway is observed when PAR-1 or GP IIb/IIIa is inhibited. The recognition sites involved in the cross-linking of polymerizing fibrin and surface integrins via the GP Ib pathway are different from those associated with fibrinogen. This pathway is insensitive to RGDS and anti-GP IIb/IIIa antibodies but reactive with a mutant fibrinogen, gamma407, with a deletion of the gamma-chain sequence, AGDV. The reaction is not due to simple trapping of platelets by the fibrin clot, since ligand binding, signal transduction, and second messenger formation are required. The GP Ib pathway is accompanied by mobilization of internal calcium and the platelet release reaction. This latter aspect is not observed with ristocetin-induced GP Ib-von Willebrand factor agglutination nor with GP Ib-von Willebrand factor-polymerizing fibrin trapping of platelets. Human platelets also respond to gamma-thrombin, an autoproteolytic product of alpha-thrombin, through PAR-4. Co-activation of the GP Ib, PAR-1, and PAR-4 pathways elicit synergistic responses. The presence of the GP Ib pathway may explain why anti-alpha-thrombin/anti-platelet regimens fail to completely abrogate thrombosis/restenosis in the cardiac patient.
Попутный нефтяной газ: подготовка, транспортировка и переработка
Creators: name: Муллахметова Л.И.
name: Черкасова Е.И.
Publisher: name: Вестник Казанского технологического университета
Year: 2015
Subjects: ПОПУТНЫЙ НЕФТЯНОЙ ГАЗ
ASSOCIATED OIL GAS
ТЕХНОЛОГИИ ПОДГОТОВКИ
TECHNOLOGY OF PREPARATION
ТРАНСПОРТИРОВКИ И УТИЛИЗАЦИИ
TRANSPORTATION AND DISPOSAL

description: Описаны методы подготовки и переработки попутного нефтяного газа с целью его эффективного использования, приведены перспективные способы реализации и использования попутного газа непосредственно на месторождениях, показаны преимущества и недостатки методов.
(1771) Richard Shuttleworth Streatfeild
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1767) Barbara Isabella Lawson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Novel PDZ Protein Regulates the Activity of Guanylyl Cyclase C, the Heat-stable Enterotoxin Receptor
Creators: name: Thelin, William R.
name: Milgram, Sharon L.
name: Scott, Robert O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Secretory diarrhea is the leading cause of infectious diarrhea in humans. Secretory diarrhea may be caused by binding of heat-stable enterotoxins to the intestinal receptor guanylyl cyclase C (GCC). Activation of GCC catalyzes the formation of cGMP, initiating a signaling cascade that opens the cystic fibrosis transmembrane conductance regulator chloride channel at the apical cell surface. To identify proteins that regulate the trafficking or function of GCC, we used the unique COOH terminus of GCC as the "bait" to screen a human intestinal yeast two-hybrid library. We identified a novel protein, IKEPP (intestinal and kidney-enriched PDZ protein) that associates with the COOH terminus of GCC in biochemical assays and by co-immunoprecipitation. IKEPP is expressed in the intestinal epithelium, where it is preferentially accumulated at the apical surface. The GCC-IKEPP interaction is not required for the efficient targeting of GCC to the apical cell surface. Rather, the association with IKEPP significantly inhibits heat-stable enterotoxin-mediated activation of GCC. Our findings are the first to identify a regulatory protein that associates with GCC to modulate the catalytic activity of the enzyme and provides new insights in mechanisms that regulate GCC activity in response to bacterial toxin.
Performing Communism in the American Dance: Culture, Politics and the New Dance Group
Creators: Phillips, Victoria
Publisher: name: Columbia University
Year: 2008
Subjects: Propaganda, Communist
Dance
History

description: In 1931 the Workers Cultural Federation declared: ‘‘Art is a weapon.’’ Within six months the New Dance Group (NDG) premiered in New York City. The following year it appeared as a member of the Worker's Dance League and deployed the slogan ‘‘The Dance is a Weapon of the Class Struggle.’’ The NDG program notes explained: ‘‘The working class is growing in number, growing in strength, and growing in knowledge. It is simultaneously developing itself and its weapons. One of its most important weapons is our modern revolutionary dance.’’ The NDG and WDL dancers brought Communist propaganda tools to cultural projects.
Selective Interface Control of Order Parameters in Complex Oxides
Creators: name: Meyers, D.
name: Liu, Jian
name: Freeland, J. W.
name: Middey, S.
name: Kareev, M.
name: Zuo, J. M.
name: Chuang, Yi-De
name: Kim, Jong Woo
name: Ryan, P. J.
name: Chakhalian, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In complex materials observed electronic phases and transitions between them often involves coupling between many degrees of freedom whose entanglement convolutes understanding of the instigating mechanism. Metal-insulator transitions are one such problem where coupling to the structural, orbital, charge, and magnetic order parameters frequently obscures the underlying physics. Here, we demonstrate a way to unravel this conundrum by heterostructuring a prototypical multi-ordered complex oxide NdNiO3 in ultra thin geometry, which preserves the metal-to-insulator transition and bulk-like magnetic order parameter, but entirely suppresses the symmetry lowering and charge order parameter. These findings illustrate the utility of heterointerfaces as a powerful method for removing competing order parameters to gain greater insight into the nature of the transition, here revealing that the magnetic order generates the transition independently, leading to a purely electronic Mott metal-insulator transition.
description: 16 pages, 4 Figures
Effective angle of attack from Aerodynamics of manoeuvring flight in brown long-eared bats (Plecotus auritus)
Creators: name: Henningsson, Per
name: Jakobsen, Lasse
name: Hedenström, Anders
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Effective angle of attack
(1764) Ann Maria Scarlett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1766) Henry (Harry) Scarlett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Signatures of Leptoquarks at the LHC and Right-handed Neutrinos
Creators: name: Evans, Jason L.
name: Nagata, Natsumi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this paper, we argue that an extension of the Standard Model with a single leptoquark and three right-handed neutrinos can explain the excess in the first-generation leptoquark search at the LHC. We also find that when the leptoquark has similarly sized couplings to all three generations, it produces additional signals which will soon be tested in the second- and third-generation leptoquark searches, as well as in decay channels consisting of two mixed flavor leptons and two jets. If the leptoquark only couples to the first generation, on the other hand, two of the right-handed neutrinos need to be fairly degenerate in mass with the leptoquark while the other right-handed neutrinos mass should be much lighter. This hierarchical structure could explain dark matter and the baryon asymmetry of the Universe. These simple models may be regarded as benchmark models for explaining the excess, which can be tested in the next stage of the LHC running.
description: 25 pages, 2 figures
A Novel S -Adenosyl-l-methionine:Arsenic(III) Methyltransferase from Rat Liver Cytosol
Creators: name: Shi, Qing
name: Beck, Melinda A.
name: Hall, Larry L.
name: Simeonsson, Josef B.
name: Herbin-Davis, Karen M.
name: Thomas, David J.
name: Brent Nix, F.
name: Styblo, Miroslav
name: Lin, Shan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: S-Adenosyl-l-methionine (AdoMet):arsenic(III) methyltransferase, purified from liver cytosol of adult male Fischer 344 rats, catalyzes transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. The kinetics of production of methylated arsenicals in reaction mixtures containing enzyme, AdoMet, dithiothreitol, glutathione (GSH), and arsenite are consistent with a scheme in which monomethylated arsenical produced from arsenite is the substrate for a second methylation reaction that yields dimethylated arsenical. The mRNA for this protein predicts a 369-amino acid residue protein (molecular mass 41056) that contains common methyltransferase sequence motifs. Its sequence is similar to Cyt19, a putative methyltransferase, expressed in human and mouse tissues. Reverse transcription-polymerase chain reaction detects S-adenosyl-l-methionine:arsenic(III) methyltransferase mRNA in rat tissues and in HepG2 cells, a human cell line that methylates arsenite and methylarsonous acid. S-Adenosyl-l-methionine:arsenic(III) methyltransferase mRNA is not detected in UROtsa cells, an immortalized human urothelial cell line that does not methylate arsenite. Because methylation of arsenic is a critical feature of its metabolism, characterization of this enzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a carcinogen.
Activation of UBC5 Ubiquitin-conjugating Enzyme by the RING Finger of ROC1 and Assembly of Active Ubiquitin Ligases by All Cullins
Creators: name: Xiong, Yue
name: Ohta, Tomohiko
name: Furukawa, Manabu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Protein ubiquitination plays an important role in regulating the abundance and conformation of a broad range of eukaryotic proteins. This process involves a cascade of enzymes including ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). E1 and E2 represent two families of structurally related proteins and are relatively well characterized. In contrast, the nature and mechanism of E3, proposed to contain activities in catalyzing isopeptide bond formation (ubiquitin ligation) and substrate targeting, remains inadequately understood. Two major families of E3 ubiquitin ligases, the HECT (for homologous to E6-AP C terminus) family and the RING family, have been identified that utilize distinct mechanisms in promoting isopeptide bond formation. Here, we showed that purified RING finger domain of ROC1, an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, was sufficient to activate UBCH5c to synthesize polyubiquitin chains. The sequence flanking the RING finger in ROC1 did not contribute to UBCH5c activation, but was required for binding with CUL1. We demonstrated that all cullins, through their binding with ROC proteins, constituted active ubiquitin ligases, suggesting the existence in vivo of a large number of cullin-RING ubiquitin ligases. These results are consistent with the notion that the RING finger domains allosterically activate E2. We suggest that RING-E2, rather than cullin-RING, constitutes the catalytic core of the ubiquitin ligase and that one major function of the cullin subunit is to assemble the RING-E2 catalytic core and substrates together.
Odd-even mass staggering with Skyrme-Hartree-Fock-Bogoliubov theory
Creators: name: Chen, W. J.
name: Bertulani, C. A.
name: Xu, F. R.
name: Zhang, Y. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We have studied odd-even nuclear mass staggering with the Skyrme-Hartree-Fock-Bogoliubov theory by employing isoscalar and isovector contact pairing interactions. By reproducing the empirical odd-even mass differences of the Sn isotopic chain, the strengths of pairing interactions are determined. The optimal strengths adjusted in this work can give better description of odd-even mass differences than that fitted by reproducing the experimental neutron pairing gap of $^{120}$Sn.
description: 9 pages, 3 figures, submitted to PRC Brief Report
(1768) Richard James Streatfeild
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Age-related Changes in Human Bone Proteoglycan Structure: IMPACT OF OSTEOGENESIS IMPERFECTA
Creators: name: Gehron Robey, Pamela
name: Sponseller, Paul D.
name: Grzesik, Wojciech J.
name: Frazier, Chester R.
name: Fedarko, Neal S.
name: Shapiro, Jay R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Proteoglycans (PGs) are a family of molecules that undergo extensive post-translational modifications that include addition of glycosaminoglycan (GAG) chains as well as N- and O-linked oligosaccharides to the protein core. PG composition and structure have been reported to alter with age. To test whether the post-translational modifications to PGs can serve as in vitro surrogate end point markers for chronological age, the extent of GAG modifications was determined for PGs derived from normal human bone cells of 14 donors (age range, fetal to 60 years). Isolated cells were steady state radiolabeled with (35)SO(4)(2-) and [(3)H]GlcN. For biglycan and decorin, iduronate content was linearly correlated with age (increased 1.5x between fetal and age 60 years). For the syndecan-like heparan sulfate PG, the N-sulfation of post-natal cells increased over 3.5-fold until reaching a plateau during the 4th decade of life. The amount of O-linked oligosaccharides was also found to decrease as a function of increasing normal donor age, whereas the specific activity of the metabolic precursor pool remained constant regardless of donor age. These age-related changes in post-translational modifications were then used to demonstrate that osteoblasts derived from patients with osteogenesis imperfecta did not exhibit facets of a pre-mature aging, but rather were arrested in a fetal-like phenotypic state. A growth matrix rich in thrombospondin altered PG metabolism in osteoblastic cells, resulting in the production and secretion of the fetal-like (rich in O-linked oligosaccharides) forms of decorin and biglycan. This effect was qualitatively different from the effect of transforming growth factor-beta, which predominantly altered GAGs rather than O-linked oligosaccharides. No other Arg-Gly-Asp protein (fibronectin, vitronectin, type I collagen, osteopontin, and bone sialoprotein) showed any detectable effect on PG metabolism in bone cells. These results indicate that a proper matrix stoichiometry is critical for metabolism of PGs.
Magneto-optical transport properties of monolayer phosphorene
Creators: name: Tahir, M.
name: Vasilopoulos, P.
name: Peeters, F. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The electronic properties of monolayer phosphorene are exotic due to its puckered structure and large intrinsic direct band gap. We derive and discuss its band structure in the presence of a perpendicular magnetic field. Further, we evaluate the magneto-optical Hall and longitudinal optical conductivities, as functions of temperature, magnetic field, and Fermi energy, and show that they are strongly influenced by the magnetic field. The imaginary part of the former and the real part of the latter exhibit regular {\it interband} oscillations as functions of the frequency $ω$ in the range $\hslashω\sim 1.5-2$ eV. Strong {\it intraband} responses in the latter and week ones in the former occur at much lower frequencies. The magneto-optical response can be tuned in the microwave-to-terahertz and visible frequency ranges in contrast with a conventional two-dimensional electron gas or graphene in which the response is limited to the terahertz regime. This ability to isolate carriers in an anisotropic structure may make phosphorene a promising candidate for new optical devices.
description: 7 pages and 8 figures
title: Catalogus Realis. XVI. Ästhetik, Neuere Literatur, Musik. Schema der systematischen Einteilung XVId - XVIg. Neuere Literatur (ab Erscheinungsjahr 1936).
Publisher: name: Philipps-Universität Marburg
Year: 2020
Subjects: Hassiaca
Systematik
Library and information sciences
Bibliotheks- und Informationswissenschaft

description: Elektronische Reproduktion von: Catalogus Realis. Schema der systematischen Einteilung XVId - XVIg. Neuere Literatur. - Stand: Dezember 2019. - Standort: Universität Marburg, Universitätsbibliothek. - Signatur: Sonderlesesaal. - Bemerkungen: Der vorliegende Band 75 bietet eine systematische Übersicht über die Einteilung der Systemstellen XVId (Germanistik), XVIe (Anglistik, Niederlandistik, Skandinavistik), XVIf (Romanistik), XVIg (Slavistik und Keltologie) des Catalogus Realis der Universitätsbibliothek Marburg. Der Realkatalog (Catalogus Realis) verzeichnet in systematisch-sachlicher Ordnung den Bestand der Universitätsbibliothek Marburg von den Anfängen bis 1957. Später erworbene ältere Literatur ist hier nicht verzeichnet. Mit Hilfe dieses Katalogs ist die Suche nach Literatur zu bestimmten Inhalten und Themen möglich. – Zur Systematik: Die Signaturen der einzelnen Bücher und Zeitschriften geben die Ordnung des Bestands wieder. Alle Signaturen beginnen mit einer römischen Zahl von I (1) bis XX (20), die das jeweilige Fach (Theologie, Geschichte, Medizin usw.) bezeichnet. Die weitere Untergliederung ergibt sich aus den nachfolgenden Kleinbuchstaben und arabischen Zahlen. Beispiel: XVIa A 117. Die Großbuchstaben A, B und C sind nicht Teil der Systematik, sondern bezeichnen das Format der betreffenden Bände: A = Folio (großformatige Bände), B = Quart (mittelgroße Bände), C = Oktav (kleinformatige Bände). - Digitalisiert 2020
description: [Schöne Literatur ab Erscheinungsjahr 1936] Vorbemerkung 5 5 XVId. Allgemeines. [Germanistik]. 7 7 - Mittel- und neugriechische Literatur. 8 8 - Mittel- und neulateinische Literatur. Gemein- u. altgermanische Literatur. 9 9 - Deutsche Literatur (Alt-, Mittel- u. Neuhochdeutsche Literatur) 10 10 - - Die neuhochdeutschen Schriftsteller. 16 16 - - - Goethe 17 17 XVIe. Niederländische, Skandinavische, Englische Literatur. 22 22 XVIf. Romanische Literaturen . 24 24 XVIg. Keltische, slavische und baltische Literaturen. 27 27
A Phytochrome B-PIF4-MYC2/MYC4 module inhibits secondary cell wall thickening in response to shaded light
Creators: name: Luo, F
name: Zhang, Q
name: Xin, H
name: Liu, H
name: Yang, H
name: Doblin, Monika
name: Bacic, Tony
name: Li, L
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3004
subject: Crop and pasture production
classificationCode: 4106
subject: Soil sciences

description: Secondary cell walls (SCWs) in stem cells provide mechanical strength and structural support for growth. SCW thickening varies under different light conditions. Our previous study revealed that blue light enhances SCW thickening through the redundant function of MYC2 and MYC4 directed by CRYPTOCHROME1 (CRY1) signaling in fiber cells of the Arabidopsis inflorescence stem. In this study, we find that the Arabidopsis PHYTOCHROME B mutant phyB displays thinner SCWs in stem fibers, but thicker SCWs are deposited in the PHYTOCHROME INTERACTING FACTOR (PIF) quadruple mutant pif1pif3pif4pif5 (pifq). The shaded light condition with a low ratio of red to far-red light inhibits stem SCW thickening. PIF4 interacts with MYC2 and MYC4 to affect their localization in nuclei, and this interaction results in inhibition of the MYCs’ transactivation activity on the NST1 promoter. Genetic evidence shows that regulation of SCW thickening by PIFs is dependent on MYC2/MYC4 function. Together, the results of this study reveal a PHYB-PIF4-MYC2/MYC4 module that inhibits SCW thickening in fiber cells of the Arabidopsis stem.
Bat and prey trajectories from Aerodynamics of manoeuvring flight in brown long-eared bats (Plecotus auritus)
Creators: name: Henningsson, Per
name: Jakobsen, Lasse
name: Hedenström, Anders
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 110601 Biomechanics
subject: FOS: Health sciences

description: 2D top-down view of bat and prey trajectories
ATR Enforces the Topoisomerase II-dependent G 2 Checkpoint through Inhibition of Plk1 Kinase
Creators: name: Flores, Kristina G.
name: Paules, Richard S.
name: Stephen Downes, C.
name: Deming, Paula B.
name: Kaufmann, William K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: An ATR-dependent G
The offsets between galaxies and their dark matter in Lambda-CDM
Creators: name: Schaller, Matthieu
name: Robertson, Andrew
name: Massey, Richard
name: Bower, Richard G.
name: Eke, Vincent R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use the "Evolution and Assembly of GaLaxies and their Environments" ( EAGLE ) suite of hydrodynamical cosmological simulations to measure offsets between the centres of stellar and dark matter components of galaxies. We find that the vast majority (>95%) of the simulated galaxies display an offset smaller than the gravitational softening length of the simulations (Plummer-equivalent $ε= 700$ pc), both for field galaxies and satellites in clusters and groups. We also find no systematic trailing or leading of the dark matter along a galaxy's direction of motion. The offsets are consistent with being randomly drawn from a Maxwellian distribution with $σ\leq 196$ pc. Since astrophysical effects produce no feasible analogues for the $1.62^{+0.47}_{-0.49}$ kpc offset recently observed in Abell 3827, the observational result is in tension with the collisionless cold dark matter model assumed in our simulations.
description: 5 pages, 2 figures, accepted for publication in MNRAS Letters
title: Catalogus Realis. XVI. Ästhetik, Neuere Literatur, Musik. XVIm. Musik
Publisher: name: Philipps-Universität Marburg
Year: 2020
Subjects: Library and information sciences
Bibliotheks- und Informationswissenschaft
Systematischer Katalog
Hassiaca

description: Elektronische Reproduktion von: Catalogus Realis. XVIm. Musik - Stand: Dezember 2019. - Standort: Universität Marburg, Universitätsbibliothek. - Signatur: Sonderlesesaal. - Bemerkungen: Der Katalog verzeichnet in systematisch-sachlicher Ordnung den Bestand der Universitätsbibliothek Marburg von den Anfängen bis 1957. Später erworbene ältere Literatur ist hier nicht verzeichnet. Mit Hilfe dieses Katalogs ist die Suche nach Literatur zu bestimmten Inhalten und Themen möglich. – Zur Systematik: Die Signaturen der einzelnen Bücher und Zeitschriften geben die Ordnung des Bestands wieder. Alle Signaturen beginnen mit einer römischen Zahl von I (1) bis XX (20), die das jeweilige Fach (Theologie, Geschichte, Medizin usw.) bezeichnet. Die weitere Untergliederung ergibt sich aus den nachfolgenden Kleinbuchstaben und arabischen Zahlen. Beispiel: XVIa A 117. Die Großbuchstaben A, B und C sind nicht Teil der Systematik, sondern bezeichnen das Format der betreffenden Bände: A = Folio (großformatige Bände), B = Quart (mittelgroße Bände), C = Oktav (kleinformatige Bände). - Digitalisiert 2020
Supplementary Data from Herbarium specimens reveal substantial and unexpected variation in phenological sensitivity across the eastern United States.
Creators: name: Park, Daniel S.
name: Breckheimer, Ian
name: Williams, Alex C.
name: Law, Edith
name: Ellison, Aaron M.
name: Davis, Charles C.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Tables S2 - S4; Figures S1 - S3
ADVANCES IN CLINICAL LIQUID BIOPSY: BIOFLUID EXTRACELLULAR VESICLES AS PROMISING SOURCES FOR DRUG METABOLISM AND EFFICACY SURVEILLANCE
Creators: name: Wu, Xiaofeng
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Analytical chemistry not elsewhere classified

description: Cell-derived extracellular vesicles (EVs) are increasingly being recognized as an important mediator of intercellular communication, immune response and waste disposal. Due to the prevalent dissemination in most biofluids, EVs provide a promising alternative for non-invasive liquid biopsy in clinics. With internal cargoes well-preserved by EV membranes, EV-containing DNA, RNA, proteins, lipids and metabolites are widely investigated for biomarker discovery and disease progression and therapeutics monitoring. Among them, proteins and their post-translational modifications (PTMs), are the direct phenotypic indicators of pathophysiological states. Besides, development of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has allowed high-throughput and discovery-driven bioanalysis on proteomics, including EV proteomics. Nevertheless, the translational research and clinical applications on EVs are severely hampered due to the lack of suitable and efficient isolation methods as well as robust and sensitive proteomic approaches. This dissertation proposes EV proteomic strategies for therapeutic surveillance by using a novel EV isolation technique. Chapter One introduces overall status of proteomics and phosphoproteomics in translational and clinical analysis for to-date medical sciences. Chapter Two highlights a novel EV isolation method termed EV total recovery and purification (EVtrap). Chapter Three delves into the development of a pipeline proteomic strategy that utilizes EV P450 enzymes to monitor drug metabolic behaviors. Finally, Chapter Four explores the possibility of leveraging protein PTMs in EVs, especially tyrosine phosphorylation, to indicate drug therapeutic efficacy in a clinical setting. This dissertation primarily proposes EV-based liquid biopsy for revolutionary clinical analysis, especially on longitudinal monitoring for in vivo treatment response.