cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A radio pulsing white dwarf binary star
Creators: name: Marsh, T. R.
name: Gänsicke, B. T.
name: Hümmerich, S.
name: Hambsch, F. -J.
name: Bernhard, K.
name: Lloyd, C.
name: Breedt, E.
name: Stanway, E. R.
name: Steeghs, D. T.
name: Parsons, S. G.
name: Toloza, O.
name: Schreiber, M. R.
name: Jonker, P. G.
name: van Roestel, J.
name: Kupfer, T.
name: Pala, A. F.
name: Dhillon, V. S.
name: Hardy, L. K.
name: Littlefair, S. P.
name: Aungwerojwit, A.
name: Arjyotha, S.
name: Koester, D.
name: Bochinski, J. J.
name: Haswell, C. A.
name: Frank, P.
name: Wheatley, P. J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: White dwarfs are compact stars, similar in size to Earth but ~200,000 times more massive. Isolated white dwarfs emit most of their power from ultraviolet to near-infrared wavelengths, but when in close orbits with less dense stars, white dwarfs can strip material from their companions, and the resulting mass transfer can generate atomic line and X-ray emission, as well as near- and mid-infrared radiation if the white dwarf is magnetic. However, even in binaries, white dwarfs are rarely detected at far-infrared or radio frequencies. Here we report the discovery of a white dwarf / cool star binary that emits from X-ray to radio wavelengths. The star, AR Scorpii (henceforth AR Sco), was classified in the early 1970s as a delta-Scuti star, a common variety of periodic variable star. Our observations reveal instead a 3.56 hr period close binary, pulsing in brightness on a period of 1.97 min. The pulses are so intense that AR Sco's optical flux can increase by a factor of four within 30 s, and they are detectable at radio frequencies, the first such detection for any white dwarf system. They reflect the spin of a magnetic white dwarf which we find to be slowing down on a 10^7 yr timescale. The spin-down power is an order of magnitude larger than that seen in electromagnetic radiation, which, together with an absence of obvious signs of accretion, suggests that AR Sco is primarily spin-powered. Although the pulsations are driven by the white dwarf's spin, they originate in large part from the cool star. AR Sco's broad-band spectrum is characteristic of synchrotron radiation, requiring relativistic electrons. These must either originate from near the white dwarf or be generated in situ at the M star through direct interaction with the white dwarf's magnetosphere.
description: 27 pages, 10 figures, 3 tables. Published online by Nature on 27 July 2016
Additional file 3 of High-throughput characterization of cortical microtubule arrays response to anisotropic tensile stress
Creators: name: Demes, Elsa
name: Verger, Stéphane
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Additional file 3: Figure S1. High-throughput image analysis workflow to quantify CMT arrays in pavement cells. Figure S2. 3D vs. 2D context and rational for the analysis of projected signal from curved samples. Figure S3. Sample preparation and experimental design. Figure S4. Comparison of workflow output using manual estimation vs. geometry-based prediction of tensile stress pattern around the ablation. Figure S5. Plots of time series with different time resolutions. Figure S6. Time-lapse of the GFP-MBD reporter line after ablation or mock experiment. Figure S7. Individual sample plots of CMT arrays for the GFP-MBD reporter lines. Figure S8. Individual cell plots of CMT arrays for the GFP-MBD reporter lines. Figure S9. Time-lapse of the katanin mutant bot1-7 GFP-MBD reporter line after ablation or mock experiment. Figure S10. Individual sample plots of CMT arrays for the katanin mutant bot1-7 GFP-MBD reporter lines. Figure S11. Individual cell plots of CMT arrays for the katanin mutant bot1-7 GFP-MBD reporter lines. Figure S12. Time-lapse of the mCit-MBD reporter line after ablation or mock experiment. Figure S13. Individual sample plots of CMT arrays for the mCit-MBD reporter lines. Figure S14. Individual cell plots of CMT arrays for the mCit-MBD reporter lines. Figure S15. Time-lapse of the GFP-TUA6 reporter line after ablation or mock experiment. Figure S16. Individual sample plots of CMT arrays for the GFP-TUA6 reporter lines. Figure S17. Individual cell plots of CMT arrays for the GFP-TUA6 reporter lines.
On The Relationship Between Magnetic Cancellation and UV Burst Formation
Creators: name: Nelson, C. J.
name: Doyle, J. G.
name: Erdelyi, R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Burst-like events with signatures in the UV are often observed co-spatial to strong line-of-sight photospheric magnetic fields. Several authors, for example, have noted the spatial relationship between Ellerman bombs (EBs) and Moving Magnetic Features (MMFs), regions of flux which disconnect from a sunspot or pore before propagating away in the moat flow and often displaying evidence of cancellation. In this article, data collected by the Solar Dynamics Observatory's Helioseismic and Magnetic Imager and Atmospheric Imaging Assembly are analysed in an attempt to understand the potential links between such cancellation and UV burst formation. Two MMFs from AR 11579, three bi-poles from AR 11765, and six bi-poles (four of which were co-spatial to IRIS bursts) in AR 11850 were identified for analysis. All of these cancellation features were found to have lifetimes of the order hours and cancellation rates of the order 10^14-10^15 Mx s^-1. H-alpha line wing data from the Dunn Solar Telescope's Interferometric BIdimensional Spectrometer were also available for AR 11579 facilitating a discussion of links between MMFs and EBs. Using an algebraic model of photospheric magnetic reconnection, the measured cancellation rates are then used to ascertain estimates of certain quantities (such as up-flow speeds, jet extents, and potential energy releases) which compared reasonably to the properties of EBs reported within the literature. Our results suggest that cancellation rates of the order measured here are capable of supplying enough energy to drive certain UV bursts (including EBs), however, they are not a guaranteeing condition for burst formation.
description: 13 pages, 6 figures, 2 tables in Monthly Notices of the Royal Astronomical Society 2016
Elaborarea și implementarea politicilor instituționale privind Știința Deschisă: Ghid pentru organizații de cercetare = Development and Implementation of Institutional Open Science Policies: Guidelines for Research Organizations
Creators: name: Nelly, Țurcan
name: Natalia, Cheradi
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
Institutional policy
Research organizations

description: This guide provides theoretical guidelines, explanations, comments, and suggestions on how to implement the principles outlined in the Institutional Open Science Policy in practice. The guide is intended for research organizations.
An investigation of car ownership modelling
Creators: name: Spiridonos, Fotios.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Risk and Ambiguity in Information Seeking: Eye Gaze Patterns Reveal Contextual Behaviour in Dealing with Uncertainty
Creators: name: Wittek, Peter
name: Liu, Ying-Hsang
name: Darányi, Sándor
name: Gedeon, Tom
name: Lim, Ik Soo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Retrieval (cs.IR)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Information foraging connects optimal foraging theory in ecology with how humans search for information. The theory suggests that, following an information scent, the information seeker must optimize the tradeoff between exploration by repeated steps in the search space vs. exploitation, using the resources encountered. We conjecture that this tradeoff characterizes how a user deals with uncertainty and its two aspects, risk and ambiguity in economic theory. Risk is related to the perceived quality of the actually visited patch of information, and can be reduced by exploiting and understanding the patch to a better extent. Ambiguity, on the other hand, is the opportunity cost of having higher quality patches elsewhere in the search space. The aforementioned tradeoff depends on many attributes, including traits of the user: at the two extreme ends of the spectrum, analytic and wholistic searchers employ entirely different strategies. The former type focuses on exploitation first, interspersed with bouts of exploration, whereas the latter type prefers to explore the search space first and consume later. Based on an eye-tracking study of experts' interactions with novel search interfaces in the biomedical domain, we demonstrate that perceived risk shifts the balance between exploration and exploitation in either type of users, tilting it against vs. in favour of ambiguity minimization. Since the pattern of behaviour in information foraging is quintessentially sequential, risk and ambiguity minimization cannot happen simultaneously, leading to a fundamental limit on how good such a tradeoff can be. This in turn connects information seeking with the emergent field of quantum decision theory.
description: 20 pages, 3 figures
Frequency dispersion of small-amplitude capillary waves in viscous fluids
Creators: name: Denner, Fabian
Publisher: name: arXiv
Year: 2016
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: This work presents a detailed study of the dispersion of capillary waves with small amplitude in viscous fluids using an analytically derived solution to the initial value problem of a small-amplitude capillary wave as well as direct numerical simulation. A rational parametrization for the dispersion of capillary waves in the underdamped regime is proposed, including predictions for the wavenumber of critical damping based on a harmonic oscillator model. The scaling resulting from this parametrization leads to a self-similar solution of the frequency dispersion of capillary waves that covers the entire underdamped regime, which allows an accurate evaluation of the frequency at a given wavenumber, irrespective of the fluid properties. This similarity also reveals characteristic features of capillary waves, for instance that critical damping occurs when the characteristic timescales of dispersive and dissipative mechanisms are balanced. In addition, the presented results suggest that the widely adopted hydrodynamic theory for damped capillary waves does not accurately predict the dispersion when viscous damping is significant and a new definition of the damping rate, which provides consistent accuracy in the underdamped regime, is presented.
description: Accepted manuscript for publication in Physical Review E
Additional file 1 of TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2
Creators: name: Balducci, Estelle
name: Steimlé, Thomas
name: Smith, Charlotte
name: Villarese, Patrick
name: Feroul, Mélanie
name: Payet-Bornet, Dominique
name: Kaltenbach, Sophie
name: Couronné, Lucile
name: Lhermitte, Ludovic
name: Touzart, Aurore
name: Dourthe, Marie-Emilie
name: Simonin, Mathieu
name: Baruchel, André
name: Dombret, Hervé
name: Ifrah, Norbert
name: Boissel, Nicolas
name: Nadel, Bertrand
name: Macintyre, Elizabeth
name: Cieslak, Agata
name: Asnafi, Vahid
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Supplementary materials.
Identification of potential inhibitors for LLM of Staphylococcus aureus: structure-based pharmacophore modeling, molecular dynamics, and binding free energy studies
Creators: name: Kumari, Reena
name: Dalal, Vikram
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Staphylococcus aureus causes various life-threatening diseases in humans and developed resistance to several antibiotics. Lipophilic membrane (LLM) protein regulates bacterial lysis rate and methicillin resistance level in S. aureus. To identify potential lead molecules, we performed a structure-based pharmacophore modeling by consideration of pharmacophore properties from LLM-tunicamycin complex. Further, virtual screening of ZINC database against the LLM was conducted and compounds were assessed for Lipinski and ADMET properties. Based on pharmacokinetic, and molecular docking, five potential inhibitors (ZINC000072380005, ZINC000257219974, ZINC000176045471, ZINC000035296288, and ZINC000008789934) were identified. Molecular dynamics simulation (MDS) of these five molecules was performed to evaluate the dynamics and stability of protein after binding of the ligands. Several MDS analysis like RMSD, RMSF, Rg, SASA, and PCA confirm that identified compounds exhibit higher binding affinity as compared to tunicamycin for LLM. The binding free energy analysis reveals that five compounds exhibit higher binding energy in the range of −218.76 to −159.52 kJ/mol, which is higher as compared to tunicamycin (–116.13 kJ/mol). Individual residue decomposition analysis concludes that Asn148, Asp151, Asp208, His271, and His272 of LLM play a significant role in the formation of lower energy LLM-inhibitor(s) complexes. These predicted molecules displayed pharmacological and structural properties and may be further used to develop novel antimicrobial compounds against S. aureus. Communicated by Ramaswamy H. Sarma
Syllabic segmentation of continuous spoken Chinese
Creators: name: Tang, Kai Wing.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
A comparison on the biochemical activities of Fluorescein disodium, Rose Bengal and Rhodamine 101 in the light of DNA binding, antimicrobial and cytotoxic study
Creators: name: Mohammad, Mukti
name: Saha, Ishita
name: Pal, Kunal
name: Karmakar, Parimal
name: Pandya, Prateek
name: Gazi, Harun Al Rasid
name: Islam, Md. Maidul
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Biochemical activities of Fluorescein, Rose Bengal and Rhodamine 101 were studied by DNA binding, antibacterial and cytotoxic studies. DNA binding studies were done using spectroscopic, thermodynamic and molecular modeling techniques. Antibacterial activities were investigated against a gram-negative bacteria Escherichia coli and a gram-positive bacteria Staphylococcus aureus. Cytotoxic activities were studied against Wi-38 cell line. We observed these dyes bound to minor groove of DNA and structural diversity of dyes affect the phenomenon. No significant antibacterial and cytotoxic activities of these dyes were found in our observations. Communicated by Ramaswamy H. Sarma
Operational optical turbulence forecast for the Service Mode of top-class ground based telescopes
Creators: name: Masciadri, E.
name: Lascaux, F.
name: Turchi, A.
name: Fini, L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: In this contribution we present the most relevant results obtained in the context of a feasibility study (MOSE) undertaken for ESO. The principal aim of the project was to quantify the performances of a mesoscale model (Astro-Meso-NH code) in forecasting all the main atmospherical parameters relevant for the ground-based astronomical observations and the optical turbulence (CN2 and associated integrated astroclimatic parameters) above Cerro Paranal (site of the VLT) and Cerro Armazones (site of the E-ELT). A detailed analysis on the score of success of the predictive capacities of the system have been carried out for all the astroclimatic as well as for the atmospherical parameters. Considering the excellent results that we obtained, this study proved the opportunity to implement on these two sites an automatic system to be run nightly in an operational configuration to support the scheduling of scientific programs as well as of astronomical facilities (particularly those supported by AO systems) of the VLT and the E-ELT. At the end of 2016 a new project for the implementation of a demonstrator of an operational system to be run on the two ESO's sites will start. Our team is also responsible for the implementation of a similar automatic system at Mt.Graham, site of the LBT (ALTA Project). Our system/method will permit therefore to make a step ahead in the framework of the Service Mode for new generation telescopes. Among the most exciting achieved results we cite the fact that we proved to be able to forecast CN2 profiles with a vertical resolution as high as 150 m. Such a feature is particularly crucial for all WFAO systems that require such detailed information on the OT vertical stratification on the whole 20 km above the ground. This important achievement tells us that all the WFAO systems can rely on automatic systems that are able to support their optimized use.
description: 11 pages, 8 figures, Proc. SPIE 9909 "Adaptive Optics Systems V", 99090I, 2016
Structural insights of the conserved “priming loop” of hepatitis B virus pre-genomic RNA
Creators: name: LeBlanc, Regan M.
name: Kasprzak, Wojciech K.
name: Longhini, Andrew P.
name: Olenginski, Lukasz T.
name: Abulwerdi, Fardokht
name: Ginocchio, Stefano
name: Shields, Brigit
name: Nyman, Julie
name: Svirydava, Maryia
name: Del Vecchio, Claudia
name: Ivanic, Joseph
name: Schneekloth, John S.
name: Shapiro, Bruce A.
name: Dayie, Theodore Kwaku
name: Le Grice, Stuart F. J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Initiation of protein-primed (-) strand DNA synthesis in hepatitis B virus (HBV) requires interaction of the viral polymerase with a cis-acting regulatory signal, designated epsilon (ε), located at the 5′-end of its pre-genomic RNA (pgRNA). Binding of polymerase to ε is also necessary for pgRNA encapsidation. While the mechanistic basis of this interaction remains elusive, mutagenesis studies suggest its internal 6-nt “priming loop” provides an important structural contribution. ε might therefore be considered a promising target for small molecule interventions to complement current nucleoside-analog based anti-HBV therapies. An ideal prerequisite to any RNA-directed small molecule strategy would be a detailed structural description of this important element. Herein, we present a solution NMR structure for HBV ε which, in combination with molecular dynamics and docking simulations, reports on a flexible ligand “pocket”, reminiscent of those observed in proteins. We also demonstrate the binding of the selective estrogen receptor modulators (SERMs) Raloxifene, Bazedoxifene, and a de novo derivative to the priming loop. Communicated by Ramaswamy H. Sarma
Additional file 2 of TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2
Creators: name: Balducci, Estelle
name: Steimlé, Thomas
name: Smith, Charlotte
name: Villarese, Patrick
name: Feroul, Mélanie
name: Payet-Bornet, Dominique
name: Kaltenbach, Sophie
name: Couronné, Lucile
name: Lhermitte, Ludovic
name: Touzart, Aurore
name: Dourthe, Marie-Emilie
name: Simonin, Mathieu
name: Baruchel, André
name: Dombret, Hervé
name: Ifrah, Norbert
name: Boissel, Nicolas
name: Nadel, Bertrand
name: Macintyre, Elizabeth
name: Cieslak, Agata
name: Asnafi, Vahid
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Fig. S1. Patient flow diagram. Fig. S2. Schematic representation of breakpoints in partner genes of TRD translocation. Fig. S3. Schematic representation of TRD translocations with TLX1, LMO2 and TAL1 oncogenes. Fig. S4. Schematic representation of TRD translocations with partner genes other than TLX1, LMO2, and TAL1 (A) and trans-rearrangements involving TRD (B) excluding all TREC insertions which are shown in Fig. 1. Table S1. Incidence of recurrent and non-recurrent TRD translocation partner genes. Table S2. Clinical and biological characteristics of patients exhibiting insertion of TREC from TRD and TRB loci. Table S3. TREC size.
Intrinsic localized mode and low thermal conductivity of PbSe
Creators: name: Shulumba, Nina
name: Hellman, Olle
name: Minnich, Austin J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Lead chalcogenides such as PbS, PbSe, and PbTe are of interest for their exceptional thermoelectric properties and strongly anharmonic lattice dynamics. Although PbTe has received the most attention, PbSe has a lower thermal conductivity despite being stiffer, a trend that prior first-principles calculations have not reproduced. Here, we use ab-initio calculations that explicitly account for strong anharmonicity to identify the origin of this low thermal conductivity as an anomalously large anharmonic interaction, exceeding in strength that in PbTe, between the transverse optic and longitudinal acoustic branches. The strong anharmonicity is reflected in the striking observation of an intrinsic localized mode that forms in the acoustic frequencies. Our work shows the deep insights into thermal phonons that can be obtained from ab-initio calculations that are not confined to the weak limit of anharmonicity.
description: 18 pages, 5 figures
In silico screening of small molecule modulators and their binding studies against human sirtuin-6 protein
Creators: name: Jos, Sneha
name: Aouti, Snehal
name: Unni, Sruthi
name: Haridass, Vishnupriya
name: Gogoi, Hemanga
name: Deshmukh, Prashant
name: Padmanabhan, Balasundaram
name: Padavattan, Sivaraman
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Sirtuin-6 (SIRT6), class III family of deacetylase regulates several biological functions, including transcriptional repression, telomere maintenance, and DNA repair. It is unique among sirtuin family members with diverse enzymatic functions: mono-ADP-ribosylase, deacetylase and defatty-acylase. The studies so far implicated SIRT6 role in lifespan extension, tumor suppression, and is considered as an attractive drug target for aging-related disease. In this study, we have carried out in silico screening for human SIRT6 modulators using NCI Diversity Set III library, molecular dynamic (MD) simulations to analyze the protein-ligand interaction, and validated their binding-affinity (Kd) using MicroScale Thermophoresis. This study yielded two novel compounds, ((3Z)-3-((4-(dimethylamino)phenyl)methylidene)-5-(5,6,7,8-tetrahydronaphthalen-2-yl)furan-2-one and 5-phenyl-2-(5-phenyl-2,3-dihydro-1,3-benzoxazol-2-yl)-2,3-dihydro-1,3-benzoxazole showing high-affinity interaction for SIRT6. The structural analysis from MD simulation suggests both compounds might act as substrate-analogs or mimic the nicotinamide binding. On considering the uniqueness of SIRT6 substrate binding acyl channel among sirtuin family member, binding of both compounds to the above site suggesting their specificity for SIRT6 isoform. Therefore, it may form the basis for the development of potential modulators for human SIRT6. Communicated by Ramaswamy H. Sarma
Determination of blasted rock fragmentation using a transputer array
Creators: name: Yeo, Kim Pow.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Spontaneous structural distortion of metallic Shastry-Sutherland system DyB4 by quadrupole-spin-lattice coupling
Creators: name: Sim, Hasung
name: Lee, Seongsu
name: Hong, Kun-Pyo
name: Jeong, Jaehong
name: Zhang, J. R.
name: Kamiyama, T.
name: Adroja, D. T.
name: Murray, C. A.
name: Thompson, S. P.
name: Iga, F.
name: Ji, S.
name: Khomskii, D.
name: Park, Je-Geun
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: DyB4 has a two-dimensional Shastry-Sutherland (Sh-S) lattice with strong Ising character of the Dy ions. Despite the intrinsic frustrations, surprisingly, it undergoes two successive transitions: a magnetic ordering at TN = 20K, and a quadrupole ordering at TQ=12.5 K. From high-resolution neutron and synchrotron X-ray powder diffraction studies, we have obtained full structural information on this material in all phases, and demonstrate that structural modifications occurring at quadrupolar transition lead to the lifting of frustrations inherent in the Sh-S model. Our study thus provides a complete experimental picture of how the intrinsic frustration of the Sh-S lattice can be lifted by the coupling to quadrupole moments. We show that two other factors, i.e. strong spin-orbit coupling and long-range RKKY interaction in metallic DyB4, play an important role in this behavior.
description: 12 pages, 3 figures Physical Review B, accepted
Tidally-disrupted Molecular Clouds falling to the Galactic Center
Creators: name: Tsuboi, Masato
name: Kitamura, Yoshimi
name: Uehara, Kenta
name: Miyawaki, Ryosuke
name: Miyazaki, Atsushi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We found a molecular cloud connecting from the outer region to the "Galactic Center Mini-spiral (GCMS)" which is a bundle of the ionized gas streams adjacent to Sgr A*. The molecular cloud has a filamentary appearance which is prominent in the CS J=2-1 emission line and is continuously connected with the GCMS. The velocity of the molecular cloud is also continuously connected with that of the ionized gas in the GCMS observed in the H42alpha recombination line. The morphological and kinematic relations suggest that the molecular cloud is falling from the outer region to the vicinity of Sgr A*, being disrupted by the tidal shear of Sgr A* and ionized by UV emission from the Central Cluster. We also found the SiO J=2-1 emission in the boundary area between the filamentary molecular cloud and the GCMS. There seems to exist shocked gas in the boundary area.
description: 4 pages, 1 figure, Proceedings of IAU Symposium 322 (The Multi-Messenger Astrophysics of the Galactic Centre)
title: Mounds in Chryse Planitia and Oxia Planum, Mars: an unrecognised archive of Noachian geology
Creators: name: McNeil, Joseph Douglas
Publisher: name: The Open University
Year: 2023

description: The southern margin of Chryse Planitia forms part of the martian global dichotomy boundary, dividing the ancient, rugged southern highlands from the younger plains of the northern lowlands. This region contains 14,386 isolated, positive relief, kilometre-scale landforms (‘mounds’) comparable to mesas, buttes, and inselbergs on Earth. The mounds are associated with several areas of geological and astrobiological significance including Oxia Planum, the future landing site of ESA’s ExoMars ‘Rosalind Franklin’ rover, and Mawrth Vallis, a type locality for martian phyllosilicate-bearing stratified rocks. Using high-resolution orbital remote sensing datasets, including HiRISE, CaSSIS, CTX, and CRISM, this thesis investigates the stratigraphy, age, and origins of the mounds for the first time.

 I present a map that shows the extent of the mounds in the circum-Chryse region, defines their individual morphometries and morphologies, and establishes a relationship between these characteristics that reveals an erosional origin. Through investigation of their stratigraphy, composition, and geometry, I show that the mounds are phyllosilicate-bearing remnants of the circum-Chryse highland terrains that formed through stepwise backstepping and top-down aqueous alteration of highland material during the Noachian. Prior to this erosion, therefore, the dichotomy boundary lay hundreds of kilometres further north than at present. The mounds are the last remnants of this ancient landscape, and are an accessible archive of substantial physical and chemical modification of the dichotomy. The mounds are key targets for astrobiological exploration and understanding Noachian Mars. They are the only known localities in Chryse Planitia where altered strata are interposed between unaltered strata, and thus provide the most complete record of Noachian aqueous conditions. Furthermore, I show that mound-forming material buried mission-relevant phyllosilicate-bearing plains at Oxia Planum, providing long-term protection from martian surface environments. The mounds are therefore ideal localities for ExoMars, or other future missions, to explore Mars’ aqueous history and search for biosignatures.
Structural and functional role of invariant water molecules in matrix metalloproteinases: a data-mining approach
Creators: name: Kumar, Hemant
name: Mandal, Suraj Kumar
name: Gogoi, Prerana
name: Kanaujia, Shankar Prasad
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases known to degrade extracellular matrix (ECM). Being involved in many biological and physiological processes of tissue remodeling, MMPs play a crucial role in many pathological conditions such as arthritis, cancer, cardiovascular diseases, etc. Typically, MMPs possess a propeptide, a zinc-containing catalytic domain, a hinge region and a hemopexin domain. Based on their structural domain organization and substrates, MMPs are classified into six different classes, viz. collagenases, stromelysins, gelatinases, matrilysins, membrane-type and other MMPs. As per previous studies, a set of invariant water (IW) molecules of MMP-1 (a collagenase) play a significant role in stabilizing their catalytic domain. However, a functional role of IW molecule in other classes of MMPs has not been reported yet. Thus, in this study, IW molecules of MMPs from different classes were located and their plausible role(s) have been assigned. The results suggest that IW molecules anchor the structurally and functionally essential metal ions present in the vicinity of the active site of MMPs. Further, they (in)directly interlink different structural features and bridge the active site metal ions of MMPs. This study provides the key IW molecules that are structurally and functionally relevant to MMPs and hence, in turn, might facilitate the development of potent generalized inhibitor(s) against different classes of MMPs. Communicated by Ramaswamy H. Sarma
Xenia bauiana , May 1899
Creators: name: Halász, Anna
name: Mcfadden, Catherine S.
name: Toonen, Robert
name: Benayahu, Yehuda
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Xeniidae
Xenia
Xenia bauiana

description: Xenia bauiana May, 1899
Fig. 2
Xenia bauiana May, 1899: 88
Xenia bauiana; Kükenthal 1902: 655–656
Material. Syntype: ZMB 3673, Zanzibar, 1885, coll. Sander.
Description. The syntype is 25 mm high; its stalk is 14–20 mm long and 12 mm wide at its base and 28 mm wide at the uppermost part. The polyp body is up to 9 mm long, and the tentacles are up to 4 mm long, featuring four rows of pinnules on each side. The pinnules are relatively short and slender, up to 0.50 mm long and 0.15 mm wide, 26–30 in the outermost row with no gap between adjacent pinnules.
Sclerites are ellipsoid platelets, occasionally slightly irregular 0.008 –0.014 X 0.015 –0.020 mm in diameter (Fig. 2a, n =25). They are composed of calcite rods (Fig. 2b) thus providing a granular appearance to the sclerite surface, which is mostly fractured (Fig. 1a). The ethanol-preserved holotype is brown-gray in color.
Remarks. In the original description of X. bauiana, May (1899) indicated three rows of pinnules, but not their number on the margins of the tentacles. Later, Kükenthal (1902) noted that this species features six rows, probably referring to the total number – namely, three on each side of the tentacle. Both of these descriptions lack details regarding the number of pinnules and sclerite dimensions. The current findings further indicate that the number of rows of pinnules recorded in previous studies is erroneous (May 1899: 3 rows; Kükenthal 1902: 6 rows; and this study: 4 rows).
Similar species and conclusion. Both X. bauiana and X. sansibariana feature four rows of pinnules with 26– 30 and 25–27 pinnules in the outermost row, respectively, and share the same type locality. Notably, X. sansibariana lacks sclerites and thus these two species should be considered as separate.
Distribution. Zanzibar.
description: Published as part of Halász, Anna, Mcfadden, Catherine S., Toonen, Robert & Benayahu, Yehuda, 2019, Re-description of type material of Xenia Lamarck, 1816 (Octocorallia: Xeniidae), pp. 201-239 in Zootaxa 4652 (2) on pages 206-207, DOI: 10.11646/zootaxa.4652.2.1, http://zenodo.org/record/3363653
Kinetics of Diffusion-Controlled Annihilation with Sparse Initial Conditions
Creators: name: Ben-Naim, E.
name: Krapivsky, P. L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study diffusion-controlled single-species annihilation with sparse initial conditions. In this random process, particles undergo Brownian motion, and when two particles meet, both disappear. We focus on sparse initial conditions where particles occupy a subspace of dimension $δ$ that is embedded in a larger space of dimension $d$. We find that the co-dimension $Δ=d-δ$ governs the behavior. All particles disappear when the co-dimension is sufficiently small, $Δ\leq 2$; otherwise, a finite fraction of particles indefinitely survive. We establish the asymptotic behavior of the probability $S(t)$ that a test particle survives until time $t$. When the subspace is a line, $δ=1$, we find inverse logarithmic decay, $S\sim (\ln t)^{-1}$, in three dimensions, and a modified power-law decay, $S\sim (\ln t)\,t^{-1/2}$, in two dimensions. In general, the survival probability decays algebraically when $Δ<2$, and there is an inverse logarithmic decay at the critical co-dimension $Δ=2$.
description: 5 pages, 4 figures
Development of an automatic Charpy machining cell
Creators: name: Drummond, M. .).
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Resistive Switching and Voltage Induced Modulation of Tunneling Magnetoresistance in Nanosized Perpendicular Organic Spin Valves
Creators: name: Göckeritz, Robert
name: Homonnay, Nico
name: Müller, Alexander
name: Fuhrmann, Bodo
name: Schmidt, Georg
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Nanoscale multifunctional perpendicular organic spin valves have been fabricated. The devices based on an La$_{0.7}$Sr$_{0.3}$MnO$_3$/Alq$_3$/Co trilayer show resistive switching of up to 4-5 orders of magnitude and magnetoresistance as high as -70% the latter even changing sign when voltage pulses are applied. This combination of phenomena is typically observed in multiferroic tunnel junctions where it is attributed to magnetoelectric coupling between a ferromagnet and a ferroelectric material. Modeling indicates that here the switching originates from a modification of the La$_{0.7}$Sr$_{0.3}$MnO$_3$ surface. This modification influences the tunneling of charge carriers and thus both the electrical resistance and the tunneling magnetoresistance which occurs at pinholes in the organic layer.
description: 8 pages, 5 figures
Automated Generation of High-Order Modes for Tests of Quasi-Optical Systems of Gyrotrons for W7-X Stellarator
Creators: name: Ruess, T.
name: Avramidis, K. A.
name: Gantenbein, G.
name: Ioannidis, Z.
name: Illy, S.
name: Jin, J.
name: Lutz, F.-C.
name: Marek, A.
name: Ruess, S.
name: Rzesnicki, T.
name: Thumm, M.
name: Wagner, D.
name: Weggen, J.
name: Jelonnek, J.
Publisher: name: Karlsruhe
Year: 2019

description: A test system for the verification of the quasi-optical converter system is vital in the gyrotron development. For this reason, an automated measurement setup has been developed and is benchmarked with the TE$_{28,8}$ mode operating in the cavities of the gyrotrons of W7-X with a high purity of about 95 % and a counter-rotating amount of about 0.3 %. The time duration for the mode generator adjustment has been reduced to two days for this mode. After a successful mode excitation, the quasi-optical mode converter, consisting of a launcher and three mirrors, is measured having a vectorial Gaussian mode content of 97 %.
Asymmetric structure in Sgr A* at 3mm from closure phase measurements with VLBA, GBT and LMT
Creators: name: Brinkerink, Christiaan D.
name: Müller, Cornelia
name: Falcke, Heino
name: Bower, Geoffrey C.
name: Krichbaum, Thomas P.
name: Castillo, Edgar
name: Deller, Adam T.
name: Doeleman, Sheperd S.
name: Fraga-Encinas, Raquel
name: Goddi, Ciriaco
name: Hernández-Gómez, Antonio
name: Hughes, David H.
name: Kramer, Michael
name: León-Tavares, Jonathan
name: Loinard, Laurent
name: Montaña, Alfredo
name: Mościbrodzka, Monika
name: Ortiz-León, Gisela N.
name: Sanchez-Arguelles, David
name: Tilanus, Remo P. J.
name: Wilson, Grant W.
name: Zensus, J. Anton
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the results of a closure phase analysis of 3 mm very long baseline interferometry (VLBI) measurements performed on Sagittarius A* (Sgr A*). We have analyzed observations made in May 2015 using the Very Long Baseline Array, the Robert C. Byrd Green Bank Telescope and the Large Millimeter Telescope Alfonso Serrano and obtained non-zero closure phase measurements on several station triangles - indicative of a non-point-symmetric source structure. The data are fitted with an asymmetric source structure model in Sgr A*, represented by a simple two-component model, which favours a fainter component due East of the main source. This result is discussed in light of a scattering screen with substructure or an intrinsically asymmetric source.
description: To be published in MNRAS. First published online July 19, 2016
Parking demand for small suburban offices
Creators: name: Hunkin, Peter J.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
On the role of repetitive magnetic reconnections in evolution of magnetic flux-ropes in solar corona
Creators: name: Kumar, Sanjay
name: Bhattacharyya, R.
name: Joshi, Bhuwan
name: Smolarkiewicz, P. K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Parker's magnetostatic theorem extended to astrophysical magnetofluids with large magnetic Reynolds number supports ceaseless regeneration of current sheets and hence, spontaneous magnetic reconnections recurring in time. Consequently, a scenario is possible where the repeated reconnections provide an autonomous mechanism governing emergence of coherent structures in astrophysical magnetofluids. In this work, such a scenario is explored by performing numerical computations commensurate with the magnetostatic theorem. In particular, the computations explore the evolution of a flux-rope governed by repeated reconnections in a magnetic geometry resembling bipolar loops of solar corona. The revealed morphology of the evolution process, including onset and ascent of the rope, reconnection locations and the associated topology of the magnetic field lines, agrees with observations, and thus substantiates physical realisability of the advocated mechanism.
Additional file 1 of Unveiling the enigma: physicians' perceptions of functional neurological disorders in Egypt—a cross-sectional study
Creators: name: Alamrawy, Roa Gamal
name: Abdel Tawab, Alshymaa Mohamed
name: Omran, Hoda Aly Mohamed
name: Awad, Ahmed K.
name: Rizk, Marwa Abdelazim
name: Abdelrasoul, Esraa Ahmed
name: Etman, Amira
name: Ahmed, Dina B.
name: Ali, Essam G.
name: Ahmed Kamal, Manar
Publisher: name: figshare
Year: 2023
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
classificationCode: 111714
subject: Mental Health

description: Additional file 1. Appendix 1: Sociodemographic and Professional Data Profile. Appendix 2: Views about Functional Neurological Disorders Survey.
Skyrmions at the edge: Confinement effects in Fe/Ir(111)
Creators: name: Hagemeister, J.
name: Iaia, D.
name: Vedmedenko, E. Y.
name: von Bergmann, K.
name: Kubetzka, A.
name: Wiesendanger, R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have employed spin-polarized scanning tunneling microscopy and Monte-Carlo simulations to investigate the effect of lateral confinement onto the nanoskyrmion lattice in Fe/Ir(111). We find a strong coupling of one diagonal of the square magnetic unit cell to the close-packed edges of Fe nanostructures. In triangular islands this coupling in combination with the mismatching symmetries of the islands and of the square nanoskyrmion lattice leads to frustration and triple-domain states. In direct vicinity to ferromagnetic NiFe islands, the surrounding skyrmion lattice forms additional domains. In this case a side of the square magnetic unit cell prefers a parallel orientation to the ferromagnetic edge. These experimental findings can be reproduced and explained by Monte-Carlo simulations. Here, the single-domain state of a triangular island is lower in energy, but nevertheless multi-domain states occur due to the combined effect of entropy and an intrinsic domain wall pinning arising from the skyrmionic character of the spin texture.
description: 5 pages, 4 figures, supplement not uploaded to arXiv due to size limitation
title: Soil–climate contribution to DNDC model uncertainty in simulating biomass accumulation under urban vegetable production on a Petroplinthic Cambisol in Tamale, Ghana
Creators: name: Budiman, Budiman
name: Steiner, Christoph
name: Topp, Cairistiona F. E.
name: Buerkert, Andreas
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: carbon–nitrogen modelling
subject: factor importance
subject: horticulture
subject: urban agriculture
subject: West Africa
subject: 580
subject: 630
subject: Gemüsebau
subject: Urbaner Gartenbau
subject: Denitrifikation
subject: Ghana

description: Gefördert im Rahmen des Projekts DEAL
VARIATIONS IN MEASUREMENTS OF THE GRAVITATIONAL CONSTANT DUE TO ELECTROMAGNETIC FIELD GRADIENTS
Creators: name: DAVIES, JOHN BRUCE
Publisher: name: Zenodo
Year: 2025
Subjects: G Gravitational Constant Measurements Variation Electric Field Gradients Torsion Binci Identities

description: Measurements of the Gravitational Constant G have large variations both within individual experimental runs and also between results from different experiments. Davies (1988) extended Einstein/Cartan theory and developed linearized Bianchi Identities that proved Torsion gradients contribute to Curvature and the Gravitational Field. By applying a particle-in-field model of particle-antiparticle pair production, Davies (1988) identified Curvature with the massive charged particle/antiparticle and their intermediating electroweak forces were identified with timelike components of the Torsion tensorwith identification of Maxwell's Equation in these linearized Bianchi Identities. Thus, it is to be expected that Electric field gradients in the vicinity of Gravitational Constant measurements will affect the resultant values. It is shown that observed variations both in the same experiment and between different G experiments are explained by observed values of local Electric field gradients. Davies(1988)https://zenodo.org/records/1157895