cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Materials
Creators: name: Ma, Tianyue
name: De Verteuil, Lauréanne
name: Fraser, Carly
name: Alany, Ammar
Publisher: name: OSF Registries
Year: 2020

description: All the materials included in our study (#20-58) are presented here including the Informed consent, the Debriefing form and the questionnaire for our additional measure (Eysenck's Personality Inventory).
Neuroprotective terpenoids from the leaves of Viburnum odoratissimum
Creators: name: Zhang, Yan
name: Zhou, Wei-Yu
name: Song, Xiao-Yu
name: Yao, Guo-Dong
name: Song, Shao-Jiang
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound 3 displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound 3 could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis.
A longitudinal study of bipolar disordered clients going through an intensive psycho-educational intervention program
Creators: name: Sorensen, John
Publisher: name: University of Hertfordshire
Year: 2004

description: Although it is still possible to encounter the view that medication is the only method of treatment for bipolar disorder, research shows that there is a significant need for a comprehensive and integrative approach to this complex disorder. The current thesis firstly describes the rationale and development of a new, psychological intervention specifically directed at bipolar disorder, and secondly reports on an evaluation of this approach to treatment. Using a longitudinal design with replication across 13 participants, combined with the use of multiple case study methodology and qualitative data collection strategies, which allowed for triangulation between multiple data sources, it is concluded that the newly developed Therapeutic Instability Model approach to treatment had a significant and positive impact on factors of importance when treating bipolar disorder. These factors included hopelessness, known to be predictive of suicidal behaviour, and perceived control over internal states, a central aspect of bipolar disorder. As part of the evaluation, insights into which factors are important for client satisfaction and perceived usefulness of a treatment were also gained and it is argued that these should be borne in mind when attempting to develop interventions with high effectiveness and low dropout from treatment. The study further-more found positive changes occurring as a result of the intervention in thoughts, feelings, behaviours and illness related knowledge, and began a mapping of the participants' understanding or subjective models of their disorder's aetiology and maintenance. Further, two distinct patterns of change in important variables were observed during treatment and appear to be related to the participants' general attitude to having future episodes of mania. In relation to this, it was noted that specific interventions, such as behavioural experiments, may be more important for outcomes of treatment for individuals with a positive/ambivalent attitude to mania compared with individuals who do not share this attitude to manic experiences. It was argued that these findings could have potentially important clinical implications and a number of suggestions with regards to further research in this, and other, areas relating to the study were finally made.
Convergence and divergence in opera and music theatre : supporting thesis for a folio of work
Creators: name: Barker, Paul
Publisher: name: University of Hertfordshire
Year: 2004

description: This appraisal presents various musico-dramatic works through the elucidation of source impulse and places them alongside other works in the genre, i and related works by the composer. Four of the works are operatic, in a hybrid form, I 1 which is both typical of and central to the author's creative output. The author ! 1 postulates an analytical theory that transcends the historical limitations of traditional musical, literary or dramatic presentation. For this reason the author adopts a comparative generic and historical analysis, which exposes both their debts to and departures from traditional operatic forms and structures. I Several arguments are postulated to evidence the originality of the works: the use of found or specially constructed instruments; the effect of these instruments on voices through the use of relative pitch; the absence of a traditional orchestra as the basis for an opera; the use of a vocal chorus to provide the role of an orchestra; the use of obscure languages; the use of several languages simultaneously; the symbiotic nature of music and text; the influence of the sound of the languages on the music itself; the ensuing dichotomy between meaning in music and meaning in text and the consequences for the dramatic presentation of the works. Evidence is provided from each of the works to point to originality of compositional style and idiosyncrasy of word setting, and the affects of these issues on contemporary audiences and performers. One research outcome suggests that responsibility for meaning in opera lies ultimately with the performer, rather than with the creator or the score. Such an argument could hardly be more forcibly made than when, as is the case here, both author and composer are one and the same. The works which constitute the portfolio have been performed widely, internationally, commercially recorded, broadcast on radio and some televised.
Sleep deprivation and intrinsic brain connectivity – a near-systematic review
Creators: name: Nilsonne, Gustav
Publisher: name: figshare
Year: 2017
Subjects: subject: 110999 Neurosciences not elsewhere classified
subject: FOS: Clinical medicine

description: An informal review of functional magnetic resonance imaging (fMRI) studies of intrinsic connectivity after sleep deprivation in humans. Originally published as a blog post.
Identidade cristã e cidade dos homens: notas para um ’diálogo’
Creators: name: Ambrosio, Juan
Publisher: name: Didaskalia
Year: 2007

description: Com certa frequência se ouve falar na dificuldade em compaginar a vivência da experiência cristã e a dimensão da contemporaneidade. Por vezes – demasiadas vezes – parece ficar a ideia de que uma realidade se opõe à outra. Será possível, de facto, apostar na construção da identidade cristã e simultaneamente assumir a condição de cidadão? Para o autor, não só é possível, como é indispensável e necessário. A opção cristã implica obrigatoriamente a dimensão da encarnação, o que compromete com a edificação da cidade humana em cada momento do percurso histórico da humanidade. Não é possível assumir o compromisso cristão sem simultaneamente assumir o compromisso e a corresponsabilidade da construção da história humana.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
A origem da Bioética: uma interpretação à luz da Ética e da Teologia
Creators: name: Cunha, Jorge Teixeira Da
Publisher: name: Didaskalia
Year: 2007

description: O nascimento da bioética representa um crescimento ético da humanidade. É sinal de uma sociedade que procura chegar ao nível moral pós-convencional, para usar uma terminologia de L. Kohlberg. O texto procura justificar esta afirmação e procura ir mais adiante, ao interpretar o mesmo fenómeno desde a perspectiva teológica: quando a humanidade se torna mais responsável e cria melhores condições para a protecção do bem frágil da vida, parece que isso corresponde ao divino projecto de associar o ser humano ao seu projecto criador e redentor.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
Additional file 1 of Homoprejudiced violence among Chinese men who have sex with men: a cross-sectional analysis in Guangzhou, China
Creators: name: Wu, Dan
name: Yang, Eileen
name: Huang, Wenting
name: Tang, Weiming
name: Xu, Huifang
name: Liu, Chuncheng
name: Baral, Stefan
name: Day, Suzanne
name: Tucker, Joseph D.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Additional file 1. Homoprejudiced violence questionnaire.
A ‘Destruktion’ da ideia de humanismo na encruzilhada do pensamento antigo e cristão segundo Heidegger na ‘Carta sobre o humanismo’
Creators: name: Martins, Maria Manuela Brito
Publisher: name: Didaskalia
Year: 2007

description: O objectivo deste artigo é de efectuar uma leitura da Brief über den «Humanismus» de Heidegger, tendo em conta o significado fundamental daquilo que o filósofo proclama e, em confrontação com a perspectiva existencialista, a humanitas do homo humanus. É a partir deste conceito que se parte para uma compreensão da Humanitas heideggeriana, à luz do método da Destruktion fenomenológica, de forma entender-se a ekstatic Existenz do Dasein, que instaura a “humanitas do homem numa posição suficientemente alta”. Para a sua completa realização, Heidegger intenta, de igual modo, e à luz também do pensamento cristão, pensar a essência da humanitas, através da ek-sistência ekstática do homem, em direcção da verdade do Ser e do ‘Cuidado’, aberta à deitas e ao Transcendente.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
A Igreja e a sua história: a propósito de Monsenhor Miguel de Oliveira e da história da Igreja em Portugal
Creators: name: Clemente, Manuel
Publisher: name: Didaskalia
Year: 2007

description: Pensar a Igreja e a sua História é um exercício inseparável da nomeação dos seus protagonistas. E um dos mais argutamente fecundos, na arte do fazer e do fundar, foi, no século XX português, Monsenhor Miguel de Oliveira (Válega, 1887-Lisboa, 1968), cujo perfil biográfico e científico aqui se traça. A sua múltipla investigação integrou-o num notável grupo de historiadores coetâneos; com eles fundou um Centro de Estudos e uma revista temática, a “Lusitania Sacra”; e desenvolveu uma série de estudos que ainda hoje constituem pontos de partida sólidos para a investigação.
description: Didaskalia, v. 37 n. 1 (2007): Gramáticas da plenitude: homenagem à Professora Maria Manuela de Carvalho
Encore une fois: la dernière Cène, un repas pascal
Creators: name: Manns, Frédéric
Publisher: name: Didaskalia
Year: 2007

description: A J. Jeremias se atribui o mérito de ter colocado claramente o problema: a última ceia de Jesus desenrolou-se, sim ou não, no quadro de uma refeição pascal judaica? A resposta que se dê a esta questão é de grande relevância. A Eucaristia tem raízes judaicas ou ela traduz unicamente a novidade cristã? Este será o nosso território de indagação. Como é sabido, o ponto de vista de J. Jeremias não reuniu consenso e diferentes soluções foram sendo avançadas e, sucessivamente, relativizadas. O presente texto avança com uma nova hipótese, mostrando que a Festa da Páscoa constitui, face ao acontecimento final da vida de Jesus, o critério hermenêutico mais importante.
description: Didaskalia, v. 37 n. 2 (2007): O viver crente: um mapa que se faz?
Cytotoxic activity of two natural sesquiterpene lactones, isobutyroylplenolin and arnicolide D, on human colon cancer cell line HT-29
Creators: name: Huang, Xuedan
name: Awano, Yurika
name: Maeda, Eri
name: Asada, Yoshihisa
name: Takemoto, Hiroaki
name: Watanabe, Takashi
name: Kojima-Yuasa, Akiko
name: Kobayashi, Yoshinori
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin. Treatment with isobutyroylplenolin and arnicolide D increased the levels of intracellular reactive oxygen species and decreased the levels of nuclear factor-κB protein, resulting in cell cycle arrest in G1 phase and apoptosis. We also discuss the difference in structure and activity between these two compounds.
Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure
Creators: name: Shi, Cheng
name: Han, Hong Jing
name: Fan, Li Juan
name: Guan, Jing
name: Zheng, Xing Bang
name: Chen, Xi
name: Liang, Rong
name: Zhang, Xiao Wei
name: Sun, Kun Kun
name: Cui, Qing Hua
name: Shen, Huan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: High endometrial receptivity in the window of implantation (WOI) is essential for successful implantation. However, a diagnostic tool with high specificity for impaired endometrial receptivity remains to be developed. We collected endometrium specimens during the WOI from patients with RIF and women who conceived after one IVF/ICSI attempt. We conducted mRNA microarray on the samples followed by relevant comparative and functional analysis. Microarray analysis revealed 357 dysregulated mRNAs between the two groups. The majority of these mRNAs were found to encode membrane proteins by Gene Ontology (GO) analysis. The major functional biological pathways associated with the down-regulated mRNAs were cytokine-cytokine receptor interaction, the p53 signalling pathway and the complement and coagulation cascades. Up-regulated mRNAs were found mainly to participate in pathways such as PPAR signalling, hematopoietic cell lineage, phosphatidylinositol signalling system, ECM-receptor interaction and notch signalling. AQP3, DPP4 and TIMP3 whose expression patterns were down-regulated in RIF patients both by microarray and real-time PCR had a high correspondence with previous studies demonstrating that these genes may contribute to the defects in endometrial receptivity in RIF patients. Overall, these RIF-associated mRNAs may help devise new diagnostic tools for endometrial receptivity.
Innovation durch Vielfalt: De-Kolonialisierung des Designs – Eine Analyse in drei Phasen
Creators: name: Weisser, Kathrin
Publisher: name: Universität Hamburg
Year: 2024
Subjects: De-Kolonialisierung, Safe Spaces, Dialogische Kuratierung, Co-Design

description: Innerhalb der Forschungslandschaft gewinnt de-koloniales Design zunehmend an Bedeutsamkeit. Die vorherrschenden westlichen Prinzipien, die sich in allen Lebensbereichen widerspiegeln, sind Gegenstand wissenschaftlicher Kritik. Nicht nur werden marginalisierte Gruppen vernachlässigt, sondern auch die Wahrnehmung einer westlichen Überlegenheit gefördert sowie bestehende Ungleichheiten verstärkt. Die weitreichenden Auswirkungen der Kolonialzeit und ihren komplexen Zusammenhängen haben dazu geführt, dass sich koloniales Design in die heutige Gesellschaft und ihre Strukturen integriert hat. Im Rahmen de-kolonialen Designs sollen gängige Strukturen aufgebrochen und eine kritische Auseinandersetzung mit der Vergangenheit und Gegenwart gefördert werden. So können diverse Perspektiven in Prozesse einbezogen und die Schaffung kultureller Vielfalt als neue Chancen zukünftiger Gestaltung genutzt werden. Im Rahmen des Essays werden Chancen und Herausforderungen eines de-kolonialen Forschungsprozesses mit Angehörigen der Namibian Born Frees reflektiert. Insgesamt bietet der Safe Space vielfältige Möglichkeiten unterdrückte Stimmen mehr Sichtbarkeit zu geben und in einem sicheren Umfeld neues Wissen zu generieren. Im Rahmen der Untersuchung kristallisieren sich verschiedene Herausforderungen heraus. Einerseits zeichnen sich diese in den gewählten Methodologien und Rahmenbedingungen ab, andererseits beziehen sie sich auf die erforderliche Sensibilisierung aller Akteure.
Two bioactive compounds from the Chinese scorpion Buthusmartensii Karsch
Creators: name: Gao, Jiayu
name: Yin, Weiping
name: Gao, Ting
name: Deng, Ruixue
name: Li, Xin
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Two compounds, 3β-acetoxyl,2,14,22-trihydroxy,19-hydroxymethyl,9α,5β,14β-card-20(22)enolide (1) and 1,2,3,4-tetrahydro-6-hydroxy1-5-pyrimidinecarbox-aldehyde (2), were isolated from arthropods in scorpion, Buthus martensii Karsch, by medium pressure liquid chromatography with silica gel as stationary phase and RP-HPLC analysis technology. The structures were elucidated on the basis of NMR spectroscopic analysis and HR-ESI-MS determination. It was found that (1) is a novel compound and both compounds showed inhibitory activities against the Gram-positive bacteria Bacillus subtilis (minimum inhibitory concentrations = 15 μg/mL), with diameter of inhibition zone at ϕ = 6.0 mm (compound 1) and ϕ = 9.0 mm (compound 2), respectively.
D2.1 Communication & Dissemination Plan
Creators: name: Skarpa, Andela
name: Kozaric, Marta
name: De Las Heras, Ane
name: Horgan, Denis
name: European Alliance for Personalised Medicine (EAPM)
Publisher: name: Zenodo
Year: 2025
Subjects: CAN.HEAL
communication strategy
dissemination strategy
EU4Health
CancerGenomics
public health
stakeholder engagement
oncology
healthcare innovation

description: This document outlines the Communication and Dissemination Plan (Deliverable D2.1) for the CAN.HEAL project (EU4Health Programme, Grant number: 101080009). It defines the strategy and activities for internal and external communication to maximize CAN.HEAL’s impact by optimizing knowledge exchange, building community engagement, and strengthening the dissemination of project outcomes. The plan sets out clear objectives, identifies key audiences, establishes content workflows, and details the communication channels, including website updates, social media (X/Twitter), newsletters, events, academic publications, and a Zenodo repository. The plan also includes sustainability strategies to ensure the long-term accessibility of project results post-project completion.The CAN.HEAL consortium consists of 42 partners from 17 countries, aiming to bridge health and genomics in cancer prevention, diagnosis, and treatment across Europe.
Flavonoids from the halophyte Apocynum venetum and their antifouling activities against marine biofilm-derived bacteria
Creators: name: Kong, Na-Na
name: Fang, Sheng-Tao
name: Liu, Ying
name: Wang, Jian-Hua
name: Yang, Cui-Yun
name: Xia, Chuan-Hai
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Eleven flavonoids were isolated from the leaves of the halophyte Apocynum venetum. Among them, the isolation of plumbocatechin A (1), 8-O-methylretusin (2) and kaempferol 3-O-(6″-O-acetyl)-β-d-galactopyranoside (7) was reported for the first time from this plant. Their structures were identified by using spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In addition, the antifouling activities of these compounds against the marine fouling bacteria, Bacillus thuringiensis, Pseudoalteromonas elyakovii and Pseudomonas aeruginosa, have been evaluated in this article.
ECS Sustainability and Environmental Footprint
Creators: name: EPoSS European Association on Smart Systems Integration
name: Joint EPoSS Working Group on Green ECS
name: Györvary, Erika
name: Andersson, Dag
name: Belaineh Yilma, Dagmawi
name: Blouet, Patrick
name: Collin, Daniela
name: Dallemagne, Philippe
name: Donat, Albrecht
name: Funk, Hannah
name: Gouze, Nicolas
name: Gustafsson, Jonas
name: Hakola, Liisa
name: Hildenbrand, Jutta
name: Kriegel, Kai
name: Landmann, Valentin
name: Lengger, Sabine
name: Niskala, Paavo
name: Nissen, Nils
name: Offenberg, Michael
name: Quinn, Aidan
name: Robin, Benedicte
name: Rzepka, Sven
name: Salo, Tomi
name: Sandionigi, Chiara
name: Schlagmann, Moritz
name: Schüttauf, Jan-Willem
name: Servin, Isabelle
name: Straub, Matthias
name: Summers, Jon
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Green ECS
subject: Electronic Components and Systems
subject: Sustainable economy
subject: sustainable microelectronics
subject: Microelectronics
subject: Smart Systems

description: In this White Paper, experts from the smart systems integration community of EPoSS present their views on the state-of-the-art and future technology targets in the green electronic components and systems (ECS) domain – following the EU laws and international standards set up to support the European Green Deal – and provide recommendations to European stakeholders, both public and private, regarding the next shared actions that should be taken.
Coworking Spaces: A Source of Social Support for Independent Professionals
Creators: name: Gerdenitsch, Cornelia
name: Scheel, Tabea E.
name: Andorfer, Julia
name: Korunka, Christian
Publisher: name: Humboldt-Universität zu Berlin
Year: 2016
Subjects: subject: coworking space
subject: new ways of working
subject: social support
subject: entrepreneurship
subject: ressources
subject: social interaction
subject: 150 Psychologie

description: Coworking spaces are shared office environments for independent professionals. Such spaces have been increasing rapidly throughout the world, and provide, in addition to basic business infrastructure, the opportunity for social interaction. This article explores social interaction in coworking spaces and reports the results of two studies. Study 1 (N = 69 coworkers) finds that social interaction in coworking spaces can take the form of social support. Study 2 further investigates social support among coworkers (N = 154 coworkers) and contrasts these results with those of social support among colleagues in traditional work organizations (N = 609). A moderated mediation model using time pressure and self-efficacy, based on the conservation of resources theory, is tested. Social support from both sources was positively related to performance satisfaction. Self-efficacy mediated this relationship in the employee sample, while in the coworking sample, self-efficacy only mediated the relationship between social support and performance satisfaction if time pressure was high. Thus, a mobilization of social support seems necessary in coworking spaces. We conclude that coworking spaces, as modern social work environments, should align flexible work infrastructure with well-constructed opportunities for social support.
Political budget cycles and divided government
Creators: name: Garmann, Sebastian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Political budget cycles and divided government. Regional Studies. This study empirically examines the effect of divided governments on the existence of political budget cycles. It uses a setting at the German municipality level, where divided governments occur frequently and can be clearly disentangled from the underlying political system. In this setting, the executive does not have full discretion over expenditures and tax rates, and needs support from the legislative to manipulate policy before executive elections. The study shows that political budget cycles in expenditures and tax rates are more likely when the same party controls executive and legislative. Under divided government, policy manipulation is significantly smaller.
Ethical dimensions of management decision-making : a stakeholder values approach to performance and strategy
Creators: name: Stainer, Lorice
Publisher: name: University of Hertfordshire
Year: 2003
Subjects: Management & business studies, Management

description: The research shows how organisations can improve their strategic management decision-making, in the competitive global arena, through taking into account not only economic criteria but also ethical and environmental responsibilities. This can be achieved by embracing a shared vision and common values as well as be involved with, and accountable to, stakeholders. More and more, this seems to be the way forward as it is vital for both business and society to co-exist. The ethical dimensions of corporate strategy and business performance are determined and approaches to effectively treat the consequent dilemmas are posited. Good business ethics should become a fundamental purpose rather than just an 'add-on'; this is because they contribute to an organisation achieving a reputation which can be trusted and sustained. This thinking and its implications clearly thread through the articles presented. Various frameworks and models, with guidelines and criteria, are developed to relate corporate social responsibility to performance management to create inclusive value. They are also shown to aid business decision-making in such diverse areas as empowerment, technology, competition, corporate communications, productivity and quality, environmental management and strategic organisational change. This research reveals that there is a definite synergy between business excellence and good ethical practice, when taking into consideration stakeholder expectations. This is because a purely financial model of performance is not appropriate for the 21st century. Thus, a performance-focused management system is the best vehicle for institutionalising targeted changes in the business process and galvanising action founded on high ethical standards.
Two novel amphomycin analogues from Streptomyces canus strain FIM-0916
Creators: name: Yang, Huang-Jian
name: Huang, Xiao-Zhen
name: Zhang, Zhu-Lan
name: Wang, Chuan-Xi
name: Zhou, Jian
name: Huang, Kai
name: Zhou, Jing-Ming
name: Zheng, Wei
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Three lipopeptides, the known compound amphomycin, together with two novel compounds named aspartocin D (1) and aspartocin E (2) were obtained from the fermentation broth extraction of Streptomyces canus strain FIM0916 by using various column chromatography techniques. Their structures were elucidated by using spectroscopic methods, mainly by an extensive NMR analysis. It was demonstrated that compounds 1 and 2 are novel analogues of amphomycin, whose structures are similar to aspartocins. Compounds 1 and 2 share the same cyclic decapeptide core of cyclo (Dab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), differing only in the side-chain moiety corresponding to Asp1-△3-isohendecenoic acid and Asp1-△3-isododecenoic acid, for aspartocin D and aspartocin E. In bioassays, compounds 1 and 2 exhibited antimicrobial activities against Gram-positive bacteria in the presence of Ca2+ (1.25 mM); particularly, the activities were enhanced with higher concentrations of calcium.
Supplementary Material for: Racial and Ethnic Differences in Mortality Associated with Serum Potassium in a Large Hemodialysis Cohort
Creators: name: Kim, T.
name: Rhee, C.M.
name: Streja, E.
name: Soohoo, M.
name: Obi, Y.
name: Chou, J.A.
name: Tortorici, A.R.
name: Ravel, V.A.
name: Kovesdy, C.P.
name: Kalantar-Zadeh, K.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Hyperkalemia is observed in chronic kidney disease patients and may be a risk factor for life-threatening arrhythmias and death. Race/ethnicity may be important modifiers of the potassium-mortality relationship in maintenance hemodialysis (MHD) patients given that potassium intake and excretion vary among minorities. Methods: We examined racial/ethnic differences in baseline serum potassium levels and all-cause and cardiovascular mortality using Cox proportional hazard models and restricted cubic splines in a cohort of 102,241 incident MHD patients. Serum potassium was categorized into 6 groups: ≤3.6, >3.6 to ≤4.0, >4.0 to ≤4.5 (reference), >4.5 to ≤5.0, >5.0 to ≤5.5, and >5.5 mEq/L. Models were adjusted for case-mix and malnutrition-inflammation cachexia syndrome (MICS) covariates. Results: The cohort was composed of 50% whites, 34% African-Americans, and 16% Hispanics. Hispanics tended to have the highest baseline serum potassium levels (mean ± SD: 4.58 ± 0.55 mEq/L). Patients in our cohort were followed for a median of 1.3 years (interquartile range 0.6-2.5). In our cohort, associations between higher potassium (>5.5 mEq/L) and higher mortality risk were observed in African-American and whites, but not Hispanic patients in models adjusted for case-mix and MICS covariates. While in Hispanics only, lower serum potassium (<3.6 mEq/L) levels were associated with higher mortality risk. Similar trends were observed for cardiovascular mortality. Conclusions: Higher potassium levels were associated with higher mortality risk in white and African-American MHD patients, whereas lower potassium levels were associated with higher death risk in Hispanics. Further studies are needed to determine the underlying mechanisms for the differential association between potassium and mortality across race/ethnicity.
Pressure losses associated with slurry flow in horizontal pipelines
Creators: name: Alzuhd, Tahir Hussein Hasan
Publisher: name: University of Hertfordshire
Year: 2003
Subjects: Solid liquid mixtures, Pumping machinery, Pipe Hydraulic machinery, Pneumatic machinery

description: The flow of solid liquid mixtures (slurries) has attracted much attention in research work because of its importance to industry. Prediction of pressure losses associated with slurry flow helps pipe designers select the correct pipe sizes for optimum energy consumption, equipment sizing and reliable operation of the pipeline networks. Many workers developed empirical correlations, but due to the randomness of the problem they seem of limited use in design applications because they do not contain an assessment except by trial and error, which is costly. The existence of more than one particle size poses more complexities to the slurry flow problem but it is in need in practical applications. The aims of this work are justified under the light of the observations on the state of the art in slurry transport. An experimental program is designed to highlight the effects of this problem through a predetermined set of test runs. The variables are grouped to optimise the number of experiments and to remove the effect of dimensions on the prediction method The test rig is built to serve the aims of this exercise and test runs conducted, results grouped and discussed for polyfractional slurries. A mathematical model is developed in the form of an empirical correlation. Statistical tests are employed to verify the goodness of fit. Finally, conclusions and recommendations for further work are listed
Contemporary effective population size and predicted maintenance of genetic diversity in the endangered kea (Nestor notabilis)
Creators: name: N. Dussex
name: B. C. Robertson
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Population size and the potential for maintenance of genetic diversity are critical information for the monitoring of species of conservation concern. However, direct estimates of population size are not always feasible, making indirect genetic approaches a valuable alternative. We estimated contemporary effective population size (Ne) in the endangered kea (Nestor notabilis) using three different methods. We then inferred the census size (NC) using published Ne/NC ratios and modelled the future maintenance of genetic diversity assuming a number of demographic parameters. Short-term Ne was small with a range-wide Ne NC was within the range of the current estimate (c. 1000–5000). Forward simulations showed low probability of retaining 90% of rare alleles without immigration. However, the probability of maintaining genetic diversity was high with immigration, juvenile survival of ≥ 30%, and an initial sex ratio of c. 0.5–0.6. Despite the low Ne in kea, predator control and/or artificial immigration might be sufficient to maintain the present genetic diversity.
Additional file 2 of Transcriptomic and metabolomic analysis provides insights into anthocyanin and procyanidin accumulation in pear
Creators: name: Zhang, Zhen
name: Tian, Changping
name: Zhang, Ya
name: Li, Chenzhiyu
name: Li, Xi
name: Yu, Qiang
name: Wang, Shuo
name: Wang, Xinyu
name: Chen, Xuesen
name: Feng, Shouqian
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2:Table S2. Overview of mapping of RNA-seq reads.
6′-O-Caffeoylarbutin inhibits melanogenesis in zebrafish
Creators: name: Xu, Min
name: Lao, Qiao-Cong
name: Zhao, Ping
name: Zhu, Xiao-Yu
name: Zhu, Hong-Tao
name: Luo, Xu-Lu
name: Yang, Chong-Ren
name: He, Jian-Hui
name: Li, Chun-Qi
name: Zhang, Ying-Jun
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: 6′-O-Caffeoylarbutin, an arbutin derivative, is a naturally occurring glucoside of hydroquinone from Vaccinium dunalianum. On anti-melanogenic effect assay, 6′-O-caffeoylarbutin expressed a stronger anti-melanin activity in a dose-dependent manner with about a two-fold more than that of arbutin, but with less toxicity about a two-fold lower than that of arbutin. In addition, melanin synthesis could be fully recovered after the removal of 6′-O-caffeoylarbutin. The result suggested that 6′-O-caffeoylarbutin could be a candidate natural product to serve as a skin-whitening ingredient with the merits of potent melanin inhibition, less toxicity and reversible melanin synthesis after stopping use.
A more robust wall model for use with the two-equation turbulence model
Creators: name: Mallone, Kevin Charles
Publisher: name: University of Hertfordshire
Year: 1995
Subjects: Computational fluid mechanics, Fluid mechanics

description: The applicability of computational fluid dynamics (CFD) modelling schemes to turbulent wall-bounded flows is a matter of concern. In the near-wall region of bounded flows, the standard high Reynolds number k-e model is not valid and requires the use of empirical wall models to mimic the behaviour of this region. A theoretical study of the physics of prevalent wall modelling techniques showed that the velocity distribution took no account of the pressure gradient. To determine the effect of this shortcoming, a typical transient three-dimensional flow was analysed using current CFD methods and the results compared with experimental flow measurements. Consideration of these results showed that the 'traditional' wall model was unable to replicate observed flow features in the near-wall region: further analysis of the computational results confirmed that these poor flow predictions arose from the inability of the model to consider local pressure gradient effects. Consequently, a strong case was made for a more robust wall model for use in conjunction with the standard high Reynolds number k-e model. A number of boundary layer analyses were reviewed and Coles' law of the wake (1956) presented as a viable candidate for the development of a new wall modelling scheme. In theory, Coles' law (1956) provides a description of bounded flows under arbitrary pressure gradients up to the point of near-separation and may be extended to the study of reversed flows. A generic algorithm for Coles' law was prepared and used to study the fundamental test cases of U-bend and backward facing step flows. In a comparison between documented experimentation, 'conventional' CFD modelling and Coles' law models of these flows, the Coles' law model was shown to provide a viable alternative to 'traditional' schemes. Consequently, the Coles' law model of the near-wall region, being valid for pressure-driven flows, offers an extension to the range of flows for which the standard high Reynolds number k-e model may be used.
Artificial Intelligence meets an Accessible Arctic Air Quality Forecast
Creators: name: Crotti, Ilaria
name: Cuzzucoli, Alice
name: De Marchi, Davide
name: Ramalli, Edoardo
name: Eyraud, Franck
name: Selmi, Luigi
name: PASINI, ANTONELLO
name: DOBRICIC, Srdan
Publisher: name: Zenodo
Year: 2024
Subjects: arctic
air pollution
artificial intelligence

description: Presentation of the Air Quality Forecast for Arctic Communities (AURORAE) service @ Arctic PASSION online seminar and dialogue series
Theoretical model for laser ablation outcome predictions in brain: calibration and validation on clinical MR thermometry images
Creators: name: Fahrenholtz, Samuel John
name: Madankan, Reza
name: Shabbar Danish
name: Hazle, John D.
name: R. Jason Stafford
name: Fuentes, David
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology

description: Purpose: Neurosurgical laser ablation is experiencing a renaissance. Computational tools for ablation planning aim to further improve the intervention. Here, global optimisation and inverse problems are demonstrated to train a model that predicts maximum laser ablation extent. Methods: A closed-form steady state model is trained on and then subsequently compared to N = 20 retrospective clinical MR thermometry datasets. Dice similarity coefficient (DSC) is calculated to provide a measure of region overlap between the 57 °C isotherms of the thermometry data and the model-predicted ablation regions; 57 °C is a tissue death surrogate at thermal steady state. A global optimisation scheme samples the dominant model parameter sensitivities, blood perfusion (ω) and optical parameter (μeff) values, throughout a parameter space totalling 11 440 value-pairs. This represents a lookup table of μeff–ω pairs with the corresponding DSC value for each patient dataset. The μeff–ω pair with the maximum DSC calibrates the model parameters, maximising predictive value for each patient. Finally, leave-one-out cross-validation with global optimisation information trains the model on the entire clinical dataset, and compares against the model naïvely using literature values for ω and μeff. Results: When using naïve literature values, the model’s mean DSC is 0.67 whereas the calibrated model produces 0.82 during cross-validation, an improvement of 0.15 in overlap with the patient data. The 95% confidence interval of the mean difference is 0.083–0.23 (p Conclusions: During cross-validation, the calibrated model is superior to the naïve model as measured by DSC, with +22% mean prediction accuracy. Calibration empowers a relatively simple model to become more predictive.
New alkaloids from Aconitum taipaicum and their cytotoxic activities
Creators: name: Xu, Ying
name: Zhang, Hui
name: Guo, Zeng-Jun
name: Li, Meng-Yi
name: Xi, Ke
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A–C (1–3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.
A new flavonoid from the aerial parts of Andrographis paniculata
Creators: name: He, Hao
name: Qiu, Feng
name: Chen, Li-Xia
name: Xia, Gui-Yang
name: Zhou, Kai-Lan
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: A new flavonoid, 7,8-dimethoxy-2′-hydroxy-5-O-β-d-glucopyranosyloxyflavone (1), along with 15 known flavonoids (2–16), was isolated from the aerial parts of Andrographis paniculata Nees. Their structures were elucidated on the basis of chemical and spectroscopic analyses. Most of them have uncommon O-substitution patterns involving 5-, 7-, 8-, 2′-, 3′-, 4′- and 5′-O-substituents. The antiproliferative effects of these flavonoids against human leukaemia HL-60 cells were investigated. Among them, 13 was the most active, displaying potent antiproliferative activity with IC50 of 3.50 μM. The structure–activity relationships of these isolated compounds were discussed.
The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders
Creators: name: Law, Kelsey B.
name: Bronte-Tinkew, Dana
name: Pietro, Erminia Di
name: Snowden, Ann
name: Jones, Richard O.
name: Moser, Ann
name: Brumell, John H.
name: Braverman, Nancy
name: Kim, Peter K.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer

description: Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. The majority of PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) required for cycling PEX5 for peroxisomal matrix protein import. Mutations in these genes are thought to result in a defect in peroxisome assembly by preventing the import of matrix proteins. However, we show here that loss of the AAA-complex does not prevent matrix protein import, but instead causes an upregulation of peroxisome degradation by macroautophagy, or pexophagy. The loss of AAA-complex function in cells results in the accumulation of ubiquitinated PEX5 on the peroxisomal membrane that signals pexophagy. Inhibiting autophagy by genetic or pharmacological approaches rescues peroxisome number, protein import and function. Our findings suggest that the peroxisomal AAA-complex is required for peroxisome quality control, whereas its absence results in the selective degradation of the peroxisome. Thus the loss of peroxisomes in PBD patients with mutations in their peroxisomal AAA-complex is a result of increased pexophagy. Our study also provides a framework for the development of novel therapeutic treatments for PBDs.
Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms
Creators: name: Lu, Dan
name: Yan, Zhaowei
name: Liu, Jinping
name: Narlawar, Rajeshwar
name: Groundwater, Paul
name: Li, Pingya
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Two new ceramides, (3S,4S,5R)-3-octadecanoylamino-4-hydroxy-5-dodecane-2,3,4,5-tetrahydrofuran (1) and (3S,4S,5R)-3-[(2R)-2-hydroxyhexacosanoylamino]-4-hydroxy-5-[(4E)-dodecane-4-ene]-2,3,4,5-tetrahydrofuran (2), together with eight known compounds, eleutheroside A (3), eleutheroside B (4), eleutheroside E (5), 7-hydroxy-6-methoxy-coumarin (6), 6,7-dimethoxycoumarin (7), 5α,8α-epidioxyergosta-6,22-dien-3-ol (8), stigmasterol (9) and rutin (10), were isolated from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Their structures were elucidated by means of physicochemical properties and spectroscopic methods (1D, 2D NMR and MS).
The endocrine disruption potential of betamethasone using Japanese medaka as a fish model
Creators: name: Vestel, Jessica S.
name: Hong, Jun-Yan
name: Qingyu Meng
name: Naumann, Bruce D.
name: Robson, Mark G.
name: Sargent, Edward V.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The presence of synthetic glucocorticosteroids (GCs) in surface water and their potential endocrine disruption (ED) activity at environmental concentrations has not been fully investigated. Synthetic GCs may interfere with endogenous receptors within the hypothalamic-pituitary-gonadal (HPG) axis and disruptions of this pathway can result in decreased reproduction and/or adverse developmental effects. Betamethasone, a synthetic GC, has been on the market in the United States since the 1980's. The Pharmaceutical Assessment and Transport Evaluation model estimated betamethasone concentrations to be <0.6 ng/L in 95% of all U.S. surface waters. Concentrations of 0.01, 0.1, and 1.0 µg betamethasone/L were used in a two-generation fish full life cycle study with Japanese medaka. Gross endpoints, secondary sexual characteristics, and vitellogenin expression were evaluated. The highest concentration at which ED outcomes are not anticipated was determined to be 0.1 µg/L. The ratio of the predicted environmental concentration to the no effect concentration for ED is less than one, indicating no risk to aquatic life from environmentally relevant concentrations of betamethasone.