cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Role of Scavenger Receptor-A in Heat Shock Protein 27-mediated Atheroprotection: Mechanistic Insights into a Novel Anti-atherogenic Therapy
Creators: name: Raizman, Joshua E.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: scavenger receptor-A
heat shock protein 27
macrophage
foam cell formation
atherosclerosis
acetylated low density lipoprotein
NF-kappa b

description: Heat shock protein (HSP)27 is traditionally described as an intracellular chaperone and signaling molecule, but growing evidence suggests it is released from immune cells where it plays an anti-inflammatory role during atherogenesis. Previously, the O’Brien lab found that overexpression of HSP27 led to augmented HSP27 serum levels in female apolipoprotein E knockout (ApoE-/-) mice, attenuated atherogenesis, and inhibited macrophage foam cell formation via physical binding with scavenger receptor (SR)-A. However, the precise mechanism of atheroprotection remained elusive. This thesis sought to ascertain the mechanism(s) by which HSP27 prevents foam cell formation, and determine if SR-A, a key receptor involved in the uptake of lipid into macrophages, plays an important role in HSP27-mediated atheroprotection. Pre-treatment of human macrophages with recombinant HSP27 (rHSP27) inhibited acytelated low density lipoprotein (acLDL) binding and uptake independent from receptor competition effect. Reduction in uptake was associated with attenuation of expression of SR-A mRNA, total protein, and cell surface expression. To explore the signaling mechanism by which HSP27 modulated SR-A expression it was hypothesized that nuclear factor-kappa B (NF-kB), a major regulator of many atherosclerosis gene programs, is altered by extracellular HSP27. Indeed, rHSP27 markedly activated NF-kB signaling in macrophages. Using an inhibitor of NF-kBsignaling there was an attenuation of rHSP27-induced inhibition of SR-A gene and protein expression, as well as lipid uptake, suggesting that SR-A expression is regulated by NF-kB activation. Lastly, to investigate if SR-A is required for HSP27-mediated atheroprotection in vivo, ApoE-/- and ApoE-/-SR-A-/- mice fed a high fat diet were treated with rHSP25, the mouse orthologue of HSP27, or PBS for 3 weeks. While rHSP25 therapy equally reduced serum cholesterol levels in the mouse cohorts, aortic atherogenesis, assessed using en face and sinus cross-sectional analyses, was attenuated in ApoE-/- mice but not ApoE-/-SR-A-/- mice. In conclusion, rHSP27 inhibits foam cell formation by downregulating SR-A expression. This effect may be associated with NF-kB activation. Reductions in atherosclerotic burden by rHSP27 require SR-A, and are independent of changes in serum cholesterol levels, highlighting the importance of macrophage lipid uptake in atherogenesis. Results presented in this thesis demonstrate that SR-A is a major target for HSP27 atheroprotection in the vessel wall, and provide an impetus for further studies that investigate the potential therapeutic value of HSP27.
Environmental Factors and Transnational Migration: A Case Study with Filipino Newcomers in Ottawa, Canada
Creators: name: Obokata, Reiko
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Environment
Migration
Transnationalism
Filipino

description: A number of international documents, NGOs and scholars have predicted that due to global environmental/climate change, the increased frequency and intensity of phenomena such as natural disasters, flooding, sea-level rise, pollution, and drought will be felt particularly in less developed regions of the world, and may force millions of people to leave their homelands. Given the far-reaching humanitarian and security concerns that have arisen with regard to the issue of environmentally-motivated migration, there have been calls for more empirical work to investigate this phenomenon, and particularly with respect to international movement. This thesis project takes a qualitative approach to investigating how environmental conditions in the Philippines are influencing migration to Ottawa, Canada. Using semi-structured focus group and personal interviews, it contributes some of the first ever empirical research on the links between environment and international migration to Canada. In taking a qualitative approach, it focuses on the perceptions and experiences of migrants themselves, and suggests that an emphasis on personal agency should be privileged to a greater extent in the environmental migration field. Additionally, by conducting research from a “receiving” country in the Global North, this research separates itself from the majority of previous empirical work in its field which has primarily been conducted in environmentally marginal areas in the Global South. In so doing, it provides a novel perspective particular to the experiences of long-distance and more permanent migrants. The results show that environmental factors are not currently perceived as migration influences for Filipino newcomers in Ottawa, although environmental factors do interact with political and economic factors in complex ways to influence migration decisions. This paper utilizes a transnational lens to demonstrate that environmental conditions in the Philippines may not act as direct migration influences, but they do impact migrants and their families through the social fields that are created between the Philippines and Canada. Previous work has primarily investigated the environment as a “push” factor of migration, making the transnational perspective an important theoretical contribution for addressing links between environmental change and remittances, family separation, and agency and power in relation to (im)mobility.
Assessing how health information needs of individuals with colorectal cancer are met across the care continuum: an international cross-sectional survey
Creators: name: Dau, Hallie
name: Safari, Abdollah
name: Saad El Din, Khalid
name: McTaggart-Cowan, Helen
name: Loree, Jonathan M.
name: Gill, Sharlene
name: De Vera, Mary
Publisher: name: BioMed Central
Year: 2020

description: Background: Studies evaluating health information needs in colorectal cancer (CRC) lack specificity in terms of study samples involving patients. We assessed how health information needs of individuals with CRC are met across the care continuum. Methods: We administered an international, online based survey. Participants were eligible for the study if they: 1) were 18 years of age or older; 2) received a diagnosis of CRC; and 3) were able to complete the online health survey in English, French, Spanish, or Mandarin. We grouped participants according to treatment status. The survey comprised sections: 1) demographic and cancer characteristics; 2) health information needs; and 3) health status and quality of life. We used multivariable regression models to identify factors associated with having health information needs met and evaluated impacts on health-related outcomes. Results: We analyzed survey responses from 1041 participants including 258 who were currently undergoing treatment and 783 who had completed treatment. Findings suggest that information needs regarding CRC treatments were largely met. However, we found unmet information needs regarding psychosocial impacts of CRC. This includes work/employment, mental health, sexual activity, and nutrition and diet. We did not identify significant predictors of having met health information needs, however, among participants undergoing treatment, those with colon cancer were more likely to have met health information needs regarding their treatments as compared to those with rectal cancer (0.125, 95% CI, 0.00 to 0.25, p-value = 0.051). Conclusions: Our study provides a comprehensive assessment of health information needs among individuals with CRC across the care continuum.
Design, survey and restoration of monuments: some examples
Disegno, rilievo e restauro dei monumenti: alcuni esempi
Creators: name: Esposito, Daniela; Univeristà La Sapienza Di Roma
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: restoration; design; survey; architecture
restauro; disegno; rilievo; architettura

description: Design and architectural survey constitute a preparatory phase to the study and restoration project of a monument. The survey is the result of a pre-understanding of the work under study in the activity of measurement, both in drawing graphic drawings, reproduced in appropriate scales in graphs immediate readability, such as to enable a complete view of the work same. The work of restoration of a monument thus coincides in part with the results of the survey of the monument itself. The contribution will present a series of examples of 'good' reading of the monuments through the processing and interpretation of architectural reliefs, in view of the restoration.
description: Disegno e rilievo architettonico costituiscono una fase propedeutica allo studio e al progetto di restauro di un monumento. Il rilievo è infatti il risultato di una precomprensione critica dell’opera oggetto di studio sia nell’attività propriamente mensoria, sia nell’elaborazione grafica dei disegni, riprodotti in scale appropriate in grafici di immediata leggibilità, tali da consentire una visione unitaria dell’opera stessa. L’attività di restauro di un monumento coincide così in parte con i risultati dell’attività di rilievo del monumento stesso. Il contributo presenterà una serie di esempi di ‘buona’ lettura dei monumenti attraverso l’elaborazione e l’interpretazione di rilievi architettonici, in vista degli interventi di restauro.
description: DISEGNARECON; Vol. 5, Numero Speciale (2012) - DOCO 2012, a cura di R. Mingucci, C. Bartolomei, L. Bravo, S. Garagnani; 27-32
Case Studies in “Convento de Cristo”: recording and documentation.
Casos de estudo no Convento de Cristo: registo e documentação.
Creators: name: Mateus, Luís; Universidade Técnica De Lisboa
name: Fereira, Victor; Universidade Técnica De Lisboa
name: Aguiar, José; Universidade Técnica De Lisboa
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: Automatic Photogrammetry; Laser Scanning; recording; reflectance; Conservation
Fotogrametria automática; Varrimento laser; registo; reflectância; Conservação

description: Through examples in Convento de Cristo, it is discussed the contribution that graphical documentation produced through automatic photogrammetry, under SFM/MVS (structure-from-motion / multi-view-stereo) methodology, and laser scanning, can represent to the enhancement of the recording processes of architectural heritage, originating a base documentation more reliable, and therefore potentiating later analysis processes that have to be done by conservation agents.
description: Através de aplicações ao Convento de Cristo, discute-se o contributo que a documentação gráfica produzida através da fotogrametria automática, sob a metodologia SFM/MVS (structure-from-motion / multi-view-stereo), e do varrimento laser 3D, pode dar para a melhoria dos processos de registo do património arquitectónico, dando origem a uma documentação base mais fiel ao objecto, e por isso potenciadora dos processos de interpretação e análise a efectuar pelos agentes da Conservação.
description: DISEGNARECON; Vol. 5, Numero Speciale (2012) - DOCO 2012, a cura di R. Mingucci, C. Bartolomei, L. Bravo, S. Garagnani; 169-172
Complexité topologique
Creators: name: Poirier, Gabrielle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Complexité topologique
Topologie
LS-catégorie
Sullivan

description: Il y a seulement une dizaine d’années que l’invariant de la complexité topologique a été défini. Il y a encore beaucoup de travail à y consacrer. Ici nous comparons algébriquement les deux invariants TC(X) et tc(X). En fait, ce qui nous motive, c’est la conjecture de leur égalité. Dans le but d’appuyer cette conjecture, nous regardons les bornes inférieures et supérieures de chacun, pour resserrer l’intervalle dans lequel ils se trouvent. Ceci nous a permis de trouver un nouveau résultat: la borne supérieure 2cat(X) de TC(X) est aussi une borne supérieure de tc(X). Ensuite, pour trois espaces nous avons calculé l’intervalle dans lequel se trouvent TC(X) et tc(X). Tous nos résultats nous incitent à dire que ces deux invariants se comportent bien de la même façon.
title: Nachdenken hilft: Seidels Reise durch die Psychiatrie
Creators: name: Söhner, Felicitas
name: Becker, Thomas
name: Seidel, Ralf
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: Sozialpsychiatrische Informationen, vol. 53, no. 1, p. 70
title: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie 12/22
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2022
Subjects: subject: 610

description: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie, vol. 2022, no. 12
Les effets de la perception santé des aliments sur la compensation post-exercice chez les femmes adultes inactives
Creators: name: Lafreniere, Jacynthe
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: exercice
compensation
perception alimentaire
apport énergétique

description: Cette thèse est le compte-rendu d’une expérimentation visant à explorer l’effet de la perception des aliments sur la prise alimentaire en réponse à l’exercice. Plus précisément, l’objectif était d’observer si l’opinion d’un produit est influencée par l’étiquetage utilisé pour le décrire comme étant riche ou faible en gras et si cette opinion influence l’appétit et la prise alimentaire immédiatement après une séance d’exercice ainsi que dans les 34 heures subséquentes. Dans un protocole en chassé-croisé, quatorze femmes inactives, mais en bonne santé ont été soumises aléatoirement à quatre séances expérimentales (Contrôle-Faible en gras; Contrôle-Riche en gras; Exercice-Faible en gras; Exercice-Riche en gras) où la dépense énergétique était fixée à 300kcal et obtenu lors d’une séance de marche ou course sur tapis roulant à 70% de la VO2peak des participantes. Aucune différence ne fut observée en ce qui a trait à l’apport énergétique au dîner et au cours des 34 heures qui ont suivies les conditions expérimentales, mais la réponse des participantes fut significativement influencée par leur niveau de stress. Les aliments présentés comme faibles en gras ont été jugés significativement plus santé, moins enclin à engendrer un gain de poids et plus appropriés dans un menu sain bien qu’une différence attribuable aux préconceptions des participantes a été observée entre les aliments offerts. Il s’agit de la première étude à mettre en lumière un effet de l’exercice sur la perception santé des aliments ce qui ouvre la porte à l’inclusion de ce facteur dans la recherche sur la compensation énergétique associée à l’exercice.
DoCo2012: a perspective of work and research?
DoCo2012 : una prospettiva di lavoro e di ricerca?
Creators: name: Mingucci, Roberto; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012

description: DOCUMENTATION AND CONSERVATION OF THE ARCHITECTURAL AND URBAN HERITAGE
description: DOCUMENTAZIONE E CONSERVAZIONE DEL PATRIMONIO ARCHITETTONICO ED URBANO.
description: DISEGNARECON; Vol. 5, Numero Speciale (2012) - DOCO 2012, a cura di R. Mingucci, C. Bartolomei, L. Bravo, S. Garagnani; 1-2
La sécurité arctique 2000-2010 : une décennie turbulente?
Creators: name: Landriault, Mathieu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: souveraineté arctique
Inuit
sécurité arctique
Grand nord assiégé
Passage du Nord-Ouest
politique étrangère canadienne
crises de souveraineté

description: Cette thèse a pour but d’analyser l’émergence et l’évolution de différents discours portant sur la sécurité et la souveraineté arctiques au Canada, pendant la décennie 2000-2010. Notre regard portera plus précisément sur le discours du Grand Nord assiégé. Une de nos questions de recherche fut de comprendre comment des évaluations optimistes et pessimistes du portrait sécuritaire arctique au Canada se sont traduites dans les discours sécuritaires arctiques tenus par différents acteurs politiques canadiens au cours de la décennie 2000-2010. De plus, une deuxième question de recherche se demandera si des groupes de la société civile canadienne ont été à même de formuler des idées sécuritaires alternatives à celles défendues par le gouvernement canadien. Pour ce faire, nous réaliserons une analyse de contenu qualitative de trois différents acteurs politiques canadiens : le gouvernement fédéral, les médias, plus particulièrement les textes d’opinion dans les quotidiens canadiens, et les groupes inuits. Une attention particulière sera portée à trois crises de souveraineté ayant éclaté durant cette période : la crise de l’île de Hans (été 2005), celle du sous-américain USS Charlotte (hiver 2005-2006) et la crise du drapeau russe sous le pôle nord (été 2007). Nos conclusions nous indiquent que le discours pessimiste a été exprimé en tout premier lieu dans les médias canadiens avant d’être inséré dans la rhétorique gouvernementale en 2005. De plus, les menaces étatiques vont davantage mobiliser les différents acteurs politiques canadiens étudiés que les menaces non-étatiques. La menace russe en particulier a été utilisée pour justifier des mesures additionnelles de défense de la souveraineté canadienne en Arctique. Sur notre deuxième question de recherche, nous pouvons observer que la société civile canadienne a été capable d’exprimer des idées sécuritaires alternatives. Par contre, les idées dominantes du continentalisme et du nationalisme ont guidé la politique étrangère canadienne pendant une bonne partie de la décennie, l’internationalisme libéral étant marginalisé par la prédominance de celles-ci. De plus, les groupes inuits ont été les plus à même de formuler des conceptualisations alternatives de la sécurité et de la souveraineté arctiques au Canada.
title: Absorption Imaging Studies on Intrinsic GaAs
Creators: name: Kenney, John Samuel
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1993

description: A diagnostic technique has been developed which allows recording of the temporal and spatial development of electric field structures in GaAs photoconductive switches. The optical method is based on the Franz-Keldysh effect. Measurements were performed with a Nd:YAG activation laser and a GaAs laser diode as the probe laser. At low applied voltages a 100 atm wide region of high electric field is seen at the cathode only. With increasing voltage strong domain like structures emerge at the anode also. A calibration measurement shows that the electric fields in these domains are well above 50 kV/cm. At a threshold voltage, current filaments were recorded which cause a permanent current flow, the lock-on current, and at extreme levels permanent damage of the sample.
Integrated modeling for the restoration project management
Modellazione integrata per la gestione del progetto di restauro
Creators: name: Mingucci, Roberto; Università Di Bologna
name: Garagnani, Simone; Università Di Bologna
name: Manferdini, Anna Maria; Università Di Bologna
name: Bartolomei, Cristiana; Università Di Bologna
name: Cipriani, Luca; Università Di Bologna
Publisher: name: Alma Mater Studiorum, Università di Bologna
Year: 2012
Subjects: A.I.M.; information modeling; digital archive; laser scanner survey; VR
A.I.M.; Modello informativo; archivi digitali; laser scanner; VR

description: This paper introduces some possibilities offered by the Information Multimedia Archives (A.I.M.), methodology aimed at existing architectures and important historic monuments documentation. The A.I.M.’s generation process and its digital archive structure result from studies on digital modeling and computer vision intended to document informative surveys, produced during two distinct acquiring and compiling phases. The data is collected in the A.I.M. through increasing levels of detail and organized through the use of databases developed in order to be queried by mobile devices too.
description: In questo contributo vengono esaminate le possibilità offerte dagli Archivi Informativi Multimediali (A.I.M.) utilizzati nell’ambito della descrizione di architetture esistenti e monumenti di riconosciuta importanza storica. La metodologia di generazione e la strutturazione di un A.I.M. sono il risultato di studi condotti su modellazione digitale e computer vision finalizzate al rilievo documentale, prodotto attraverso due distinte fasi di acquisizione e compilazione informativa. I dati sono raccolti nell’A.I.M. attraverso livelli di dettaglio crescenti e organizzati per la loro fruizione attraverso l’uso di database sviluppati per l’utilizzo anche attraverso dispositivi mobili.
description: DISEGNARECON; Vol. 5, Numero Speciale (2012) - DOCO 2012, a cura di R. Mingucci, C. Bartolomei, L. Bravo, S. Garagnani; 103-106
A framework for an active interface to characterise compositional security contracts of software components
Creators: name: Khan, Khaled M.
name: Han, Jun
name: Zhang, Yuliang
Publisher: name: Swinburne
Year: 2024

description: This paper presents a framework for constructing compositional security contracts (CsC) based on the security property exposed by the atomic component. The framework uses interface structure of components in order to determine the CsC of software components. An active interface provides the component a basis for reasoning and assessing a component's suitability to meet certain security requirements of a particular application. Based on the security information available from the component interface, an active interface can reason whether the candidate component meets the security requirements for an envisaged systemwide application. Any security mismatches or discrepancies between components can be identified by the participating components before an actual composition takes place. Exposing the security properties of software components can be the basis for a trust relationship among components, and the exposed security could affect the underlying security of the enclosing system.
The Factors Affecting Individuals' Choice To Be Entrepreneur: A Comparison Between Efficiency-Driven Economies and Innovation-Driven Economies
Creators: name: Wang, Juanzi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Entrepreneur
Entrepreneurship

description: The purpose of this study is to examine the influence of institutional (environmental) factors and personal (attitude, human capital) factors on the probability of becoming an entrepreneur. In particular, this study aims to make a comparison between different types of economies. The data for this study is derived from the 2011 Adult Population Survey (APS), the 2011 National Expert Survey (NES) of Global Entrepreneurship Monitor (GEM) and the World Bank Database, and covers 32 countries, including efficiency-driven economies and innovation-driven countries. This study applies hierarchical logistic regression and uses multilevel modeling for the cross-country, cross-individual dataset. The results reinforce the importance of environmental factors (regulative and normative), attitude factors, and human capital factors. The findings of this proposed study will contribute to the further analysis of the GEM database to understanding the diversity of nascent entrepreneurial activities in different contexts.
The impact of rates of reactions with cosmic ray induced photons on chemical composition of protoplanetary discs
Creators: name: Zwicky, L. N.
name: Molyarova, T. S.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Cosmic rays and cosmic ray induced photons are vital components of chemical evolution in areas of interstellar medium that are impenetrable by external ultraviolet radiation. However, rates of reactions with cosmic ray induced photons used in astrochemical models were calculated for molecular clouds and can be different in protoplanetary discs, where dust grows up to larger sizes. Using ANDES astrochemical model, we study how an increase in both upper dust size and rates of reactions with cosmic ray induced photons can influence species abundances in protoplanetary discs. We show that the increase in these reactions' rates has a significant impact on the ice mass fraction in area between 2 and 20 au but has little impact on ionisation degree in disc.
description: 5 pages, 4 figures, 1 table. This is a translation from Russian to English of a paper published in INASAN Science Reports in 2021
title: Wie für mich gemacht: das neue Zentrum für individualisierte Infektionsmedizin
Creators: name: Zorn, Stefan
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 1
The impact of legalization of access to recreational Cannabis on Canadian medical users with Cancer
Creators: name: Hawley, Philippa
name: Gobbo, Monica
name: Afghari, Narsis
Publisher: name: BioMed Central
Year: 2020

description: Background: Canada legalized cannabis use for medical purposes in 1999. Legalization of cannabis for recreational purposes in October 2018 offered the opportunity to assess the impact of recreational legalization on cancer patients’ patterns of use to identify learning points that could be helpful to other countries considering similar legislation. Method: Two identical anonymous cross-sectional surveys were administered to cancer patients in British Columbia 2 months before and 3 months following legalization, with the same eligibility criteria. The prevalence of medical cannabis use, the distribution of symptoms leading to use, the most common types of cannabis products and sources, reasons for stopping using cannabis, and barriers to access were assessed. Results: The overall response rate was 27%. Both cohorts were similar regarding age (median = 66 yrs), gender (53% female), and education (approximately 85% of participants had an education level of high school graduation and higher). Respondents had multiple motives for taking cannabis, including to manage multiple symptoms, to treat cancer, and for recreational reasons. The majority of patients in both surveys did not use the legal medical access system. Comparison of the two cohorts showed that after legalization the prevalence of current cannabis use increased by 26% (23·1% to 29·1%, p-value 0·01), including an increased disclosure of recreational motive for use, from 32 to 40%. However, in the post-legalization cohort more Current Users reported problems getting cannabis (18%) than the pre-legalization cohort (8%), (p-value < 0·01). The most common barrier cited was lack of available preferred products, including edibles, as these were only available from illegal dispensaries. Conclusions: Results showed that legalization of cannabis for recreational purposes may have an impact on those who use medical cannabis. Impacts include an increase in prevalence of use; problems accessing preferred products legally; higher cost, and difficulties using a legal access system. The desired goal of regulation in reducing harms from use of illegal cannabis products are unlikely to be achieved if the legal process is less attractive to patients than use of illegal sources.
Supplementary document for Efficient Harnessing of Light from Nanoscale Emitters Deterministically Placed through Polymer-Pen Lithography at the Focus of 3D-Printed Ellipsoidal Micro-Lenses - 5419609.pdf
Creators: name: Amrithanath, Abhishek Kottaram
name: Krishnaswamy, Sridhar
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: This document details information about the FDTD simulations, chemical sysnthesis of upconversion nanoparticles and the direct laser writing process.
Prostaglandin E2 Signaling Through Kidney EP1 and EP4 Receptors; Implications in Diabetes and Hypertension
Creators: name: Thibodeau, Jean-François
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: prostaglandin receptors
diabetic nephropathy
hypertension
cyclooxygenase

description: Chronic kidney disease is defined as the appearance of kidney functional or structural injury. Cyclooxygenase and prostaglandin E2 have been implicated in the pathogenesis of diabetic nephropathy, the leading cause of chronic kidney disease. Beneficial in certain settings, inhibition of the cyclooxygenase pathway can however be detrimental in patients with compromised cardiac or renal function. Moreover, the quest for new therapies to treat diabetic nephropathy is hampered by the lack of appropriate rodent models. This doctoral thesis is a culmination of three studies, the first to determine the role of the prostaglandin E2 EP1 receptor in diabetic nephropathy, the second to elucidate the vascular prostaglandin E2 EP4 receptor’s role in hypertension and lastly to establish and characterise a novel mouse model of diabetic nephropathy. The goal being to uncover new therapeutic avenues for the treatment of CKD, its causes and/or complications.
The Determinants and Evolution of Major Inter-firm Transactions in the U.S. Apparel Sector
Creators: name: Zhao, Xiao
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Apparel sector
Transaction networks structure
Inter-firm complementarity
Inter-firm similarity
Panel data

description: This study provides a systematic description of the nature and evolution of major transactions in the U.S. apparel sector, using a theory that applies across sectors. This research investigates the determinants of the existence and magnitude of major inter-firm transactions, relying on a unique longitudinal dataset of over 2,000 of the largest transactional (buy-sell) relations between publicly traded firms in the U.S. apparel sector. The results indicate the importance of inter-firm complementarity, rather than inter-firm similarity, in explaining the sector architecture; thus contributing to the future improvement of industry classification systems. This study also contributes to a deeper understanding of the apparel sector focusing on the change in the relative importance of manufacturing activities versus service activities and in the involvement of firms from the outside apparel sector. Implications of inter-firm transactions are discussed regarding industry policies, and human and environmental welfare in manufacturing and raw materials industries.
Hydrodynamics and Morphologic Modelling of Alternative Design Scenarios Using CMS: Shippagan Gully, New Brunswick
Creators: name: Provan, Mitchel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: tidal inlet
hydrodynamics
coastal
numerical modelling
morphology
sediment transport

description: Shippagan Gully is a highly dynamic tidal inlet located on the Gulf of St-Lawrence near Le Goulet, New Brunswick. This tidal inlet is highly unusual due to the fact that the inlet has two open boundaries with phase lagged tidal cycles that drives flow through the inlet. Over the past few decades, the shipping activities through the inlet have been threatened due to the narrowing of the navigation channel caused by deposited sediment on the east side of the channel. Many engineering projects have been undertaken at Shippagan Gully in order to try and mitigate the deposition problem. However, these attempts have either been unsuccessful or the engineered structures have deteriorated over the years. This study uses the CMS-Flow and CMS-Wave numerical models to provide guidance concerning the response of the inlet to various potential interventions aimed at improving navigation safety.
Alignment of Patient and Provider Views in Health Care Intervention Programs: A Study of the Centre for Healthy Active Living at the Children’s Hospital of Eastern Ontario
Creators: name: Gajaria, Asha
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: obesity
obesity management programs
childhood obesity
alignment of views
healthcare intervention

description: This research study focuses on examining the views of patients, their families, and staff member providers of the Centre for Healthy Active Living a clinical obesity management program for children and youth at the Children’s Hospital of Eastern Ontario, in Ottawa, Canada. Qualitative methodology was used and content analysis was conducted with data obtained from family questionnaires and a provider focus group. Analysis of obtained data was conducted to determine alignment of views between patient, family, and provider views, and the formal goals of the program. Emerging themes from the data indicated that patients and families place higher value on the formal goals of “improve quality of life; improve eating behaviours; improving fitness, increasing activity levels; and empower/strengthen families.” (Children’s Hospital of Eastern Ontario, 2012). Specific recommendations with regards to each component of these goals were provided. Instrumental, procedural, systemic, and conceptual recommendations of program components were also provided.
Analyzing Value Networks for Change Decision Making in a Collaborative Environment With a Case Study in Healthcare
Creators: name: Sharif, Soroosh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Collaborative Networked Organizations
Value Network
Virtual Organizations

description: Management of Collaborative Networked Organizations faces various challenges in terms of decision-making. Particularly, in complex and multi-player environments, like healthcare, it is not easy to find the roots of low performance processes, and unmet goals. This research provides a framework, as well as associated techniques to analyze the value network, identify problematic actors, and consequently, find the best possible solution to change them. The proposed framework consists of two main components: Analyzing the value network, and Multi-Criteria Decision Making. To analyze the value network of a collaborative environment, in addition to the existing techniques, four complementary components are introduced: Actors’ value interchanges matrix, Value Gantt chart, Identifying problematic actors flowchart, and Actors’ ease of substitution table. Employing these hybrid analyses, decision makers gain a better understanding of the bottlenecks in the value network, current conditions and contributions of the involved actors, and the consequences of considering various alternatives. Then, by applying one of the Multi-Criteria Decision Making methods, and based on pre-defined criteria, possible alternatives are analyzed and outlined. As a proof of concept and validation of the proposed methods, we reviewed a scenario of patient flow and wait times in healthcare. We derive the value network for collaborative processes in a hospital, specify the roles’ of actors, identify the bottlenecks, then rank the solutions, and suggest possible changes to improve the performance of the collaborative environment.
Relationship Between the Invasive Eurasian Milfoil (Myriophyllum spicatum L.) and Macrophyte Diversity Across Spatial Scales
Creators: name: Gräfe, Simon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Charophytes
Zebra mussels

description: The effect of the invasive macrophyte Myriophyllum spicatum L. on native macrophyte diversity was studied across 21 lakes at small (1 quadrat) and large (18 quadrats) scales and in mesocosms. No relationship was observed between M. spicatum and native richness at either spatial scale, or native evenness at small scales; however, at large scales native evenness was negatively correlated with the cover of M. spicatum in lakes. This suggests that M. spicatum can grow in lakes with other dominant species, contrary to predictions that invasive species will outcompete other dominant species. While macrophyte communities were mainly distinguished by environmental and spatial variables, M. spicatum was a significant predictor of the remaining variation in community composition. Within lakes M. spicatum occurred in deep water apart from other species; however, competition studies in mesocosms did not find sufficient evidence that this isolation was due to superior competitiveness.
INKLYUZIV TA'LIM SHAROITIDA ESHITISHDA NUQSONI BO'LGAN BOLALARNI O'QITISH VA TARBIYALASH
Creators: name: Baxromova, Gulsanam
Publisher: name: Zenodo
Year: 2025

description: Maqolada inklyuziv ta`lim o`zi nima uning mohiyati. Eshitish nuqsonlarining  kelib chiqish sabablari, eshitishning patalogik buzilishlari. Kar bolalarni o`qitish va tarbiyalash jarayoni. Kar va zaif eshituvchilarning nutqini rivojlantirish xususiyatlari  va oiladagi kar bolalarni tarbiyalash jarayoni haqida so`z boradi.
title: A Hurricane Evacuation Route System Real-Time Monitoring and Distribution of Load
Creators: name: Khanal, Anup
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2009

description: Hurricane evacuation is one of the major steps in diminishing the devastating effects of hurricanes on lives and properties. The challenge in evacuating a large number of people in a short time is the severe congestion faced in the transportation network, leading to long delays and shortages. Standard hurricane evacuation plans focus on how to best utilize the main arteries. The research challenge is to not overload the fastest routes and to utilize all the routes efficiently. The evacuation routing system proposed in this thesis focuses on distributing the traffic load throughout the network, utilizing alternative routes not considered in initial planning, while not overloading those routes. Real-time traffic data is monitored through sensors on probe vehicles and taken into account to make better decisions. The proposed evacuation algorithm considers the transportation network as a resistive network, where traffic is distributed to utilize the full network. The vehicles are guided individually, and the decisions are made at a local level. This thesis shows that the proposed system opens the opportunity for greater throughput, thus a shorter overall evacuation time. A study of the evacuation of Hampton Roads demonstrates the potential to improve the throughput by 50 %.
Traduire une pluralité de discours : 'This Side Jordan' de Margaret Laurence
Creators: name: Lavoie, Caroline
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Margaret Laurence
traduction
This Side Jordan

description: Premier roman de Margaret Laurence publié en 1960, This Side Jordan oppose monde ancestral et modernité par l'entremise de personnages ghanéens et anglais qui cherchent à affirmer leur identité à la veille de l’Indépendance du Ghana. Cette thèse présente la réflexion traductologique qui a accompagné notre traduction française de ce roman. Ce qui nous intéresse, c'est la pluralité des discours que tiennent les personnages du roman et le transfert de ces discours fictifs en traduction. La question fondamentale qui a motivé cet exercice est la suivante : est-il possible de substituer une pluralité de discours tenus en anglais en 1960 par d'autres discours pluriels tenus en français en 2013 et qui se voudraient identiques? Nous tentons d'y répondre grâce à l'analyse des différents discours qui dominent dans le roman, à de nombreuses illustrations de leur passage en traduction et aux pistes de réflexion proposées par les chercheurs, en traductologie comme dans d'autres disciplines.
Does Increased Self-Compassion Improve Social Anxiety Symptomology? Results from a Mindfulness-Based Intervention for Social Anxiety Disorder
Creators: name: Thake, Jennifer
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: mindfulness
self-compassion
intervention
social anxiety

description: Purpose: This study assessed whether a mindfulness-based intervention (MBI) adapted for social anxiety disorder (SAD) led to increases in self-compassion and trait mindfulness, and whether these increases mediated change in SAD symptom severity. Methods: Participants were randomly assigned to a 12-week MBI adapted for SAD (MBI-SAD, n = 21) or a wait-list control (WLC, n = 18). The MBI-SAD included aspects of the mindfulness-based stress reduction program, as well as explicit training in self-compassion and “mindful exposure”. Participants were assessed at baseline and weeks 6 and 12. Results: The MBI-SAD resulted in higher self-compassion and trait mindfulness and lower levels of social anxiety, compared to the WLC. Mediation analyses revealed that self-compassion and aspects of trait mindfulness mediated clinical response. Implications: Results suggest that self-compassion and aspects of trait mindfulness are possible mechanisms of change for the MBI-SAD. Results and their implications are discussed.
title: Anpassung - Widerstand? Anmerkungen zur sozialpsychiatrischen Haltung im Angesicht der Digitalisierung
Creators: name: Elgeti, Hermann
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: Sozialpsychiatrische Informationen, vol. 53, no. 2, p. 11
Supplementary document for Efficient Harnessing of Light from Nanoscale Emitters Deterministically Placed through Polymer-Pen Lithography at the Focus of 3D-Printed Ellipsoidal Micro-Lenses - 5419609.pdf
Creators: name: Amrithanath, Abhishek Kottaram
name: Krishnaswamy, Sridhar
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: This document details information about the FDTD simulations, chemical sysnthesis of upconversion nanoparticles and the direct laser writing process.
Design and Calibration of a Network of RGB-D Sensors for Robotic Applications over Large Workspaces
Creators: name: Macknojia, Rizwan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: camera calibration
RGB-D imaging
3D reconstruction
3D profiling
Kinect
vehicle inspection
robotic guidance
point cloud registration
OpenNI
depth measurement
multi camera system
calibration of robot base with depth sensor

description: This thesis presents an approach for configuring and calibrating a network of RGB-D sensors used to guide a robotic arm to interact with objects that get rapidly modeled in 3D. The system is based on Microsoft Kinect sensors for 3D data acquisition. The work presented here also details an analysis and experimental study of the Kinect’s depth sensor capabilities and performance. The study comprises examination of the resolution, quantization error, and random distribution of depth data. In addition, the effects of color and reflectance characteristics of an object are also analyzed. The study examines two versions of Kinect sensors, one dedicated to operate with the Xbox 360 video game console and the more recent Microsoft Kinect for Windows version. The study of the Kinect sensor is extended to the design of a rapid acquisition system dedicated to large workspaces by the linkage of multiple Kinect units to collect 3D data over a large object, such as an automotive vehicle. A customized calibration method for this large workspace is proposed which takes advantage of the rapid 3D measurement technology embedded in the Kinect sensor and provides registration accuracy between local sections of point clouds that is within the range of the depth measurements accuracy permitted by the Kinect technology. The method is developed to calibrate all Kinect units with respect to a reference Kinect. The internal calibration of the sensor in between the color and depth measurements is also performed to optimize the alignment between the modalities. The calibration of the 3D vision system is also extended to formally estimate its configuration with respect to the base of a manipulator robot, therefore allowing for seamless integration between the proposed vision platform and the kinematic control of the robot. The resulting vision-robotic system defines the comprehensive calibration of reference Kinect with the robot. The latter can then be used to interact under visual guidance with large objects, such as vehicles, that are positioned within a significantly enlarged field of view created by the network of RGB-D sensors. The proposed design and calibration method is validated in a real world scenario where five Kinect sensors operate collaboratively to rapidly and accurately reconstruct a 180 degrees coverage of the surface shape of various types of vehicles from a set of individual acquisitions performed in a semi-controlled environment, that is an underground parking garage. The vehicle geometrical properties generated from the acquired 3D data are compared with the original dimensions of the vehicle.
In ovo Effects of Tris(1-chloro-2-propyl) phosphate (TCPP) and Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) Flame Retardants on Chicken Embryo Toxicity and Gene Expression
Creators: name: Farhat, Amani
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: mRNA expression
avian
organophosphate flame retardant
thyroid hormone
lipid metabolism
microarray
embryo developement

description: Tris(1-chloro-2-propyl) phosphate (TCPP) and tris(1,3-dichloro-2-propyl) phosphate (TDCPP) are added to polyurethane foams in a variety of industrial and consumer products to prevent flame ignition. The gradual release of these flame retardants (FRs) from such products leads to contamination of various abiotic and biotic media, including wild birds. Recent studies demonstrated endocrine-disrupting effects of TCPP and TDCPP, including alteration of circulating thyroid hormone (TH) levels. The TH-pathway is essential for normal growth and development in birds. There are limited data on the toxicological effects of TCPP and TDCPP in avian species and, prior to this work, no study has examined their effects in avian embryos. This M.Sc. thesis investigates the developmental, molecular and biochemical effects of TCPP and TDCPP in chicken (Gallus gallus domesticus) embryos via egg injection studies. TCPP delayed pipping at doses ≥9.24 μg/g, both TCPP and TDCPP reduced embryo growth at the highest dose (51.6 μg TCPP/g and 45 μg TDCPP/g), and TDCPP decreased free plasma thyroxine and gallbladder size at 7.64 μg/g and 45 μg/g, respectively. Real-time reverse transcription polymerase chain reaction was used to measure changes in mRNA levels of hepatic genes that were responsive to these FRs in a previous in vitro study. TCPP dysregulated the expression of TH-responsive genes and xenobiotic metabolizing enzymes (cytochrome P450s; CYPs), whereas TDCPP only affected CYPs. Less than 1% of the administered TCPP or TDCPP was detected in egg contents following 19 days of incubation, indicating extensive metabolism of the parent compounds. DNA microarrays were used to perform a global transcriptional analysis on liver samples from embryos that exhibited adverse effects following TDCPP injection. 47 differentially expressed genes were identified at the 45 μg/g dose. Functional analysis revealed that immune function and lipid and steroid metabolism were major targets of TDCPP toxicity and indicated a state of cholestatic liver/biliary fibrosis. Since the TH-pathway is a key regulator of metabolic homeostasis, its disruption early in development is a potential cause of the observed adverse effects. This thesis demonstrates, for the first time, developmental and endocrine-disrupting effects of TCPP and TDCPP in an avian species and attempts to link phenotypic changes to molecular-level disruptions in hopes to improve the understanding of their modes of action.