cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Increased Pathway Complexity Is a Prognostic Biomarker in Metastatic Castration-Resistant Prostate Cancer
Creators: name: De Laere, Bram
name: Crippa, Alessio
name: Mortezavi, Ashkan
name: Ghysel, Christophe
name: Rajan, Prabhakar
name: Eklund, Martin
name: Wyatt, Alexander
name: Dirix, Luc
name: Ost, Piet
name: Grönberg, Henrik
name: Lindberg, Johan
name: CORE And ProBio Investigators
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease, characterized by common and rare driver gene alterations that provide a selective growth advantage for progressing tumour cells. We hypothesized that the number of distinct gene driver alteration-affected pathways or gene classes was associated with poor prognosis in patients initiating androgen receptor signalling inhibitors (ARSi). We performed a post hoc analysis of an amalgamated baseline circulating tumour DNA (ctDNA) mutational landscape dataset of ARSi-treated men with mCRPC (n = 342). We associated the detected hotspot, pathogenic, and/or high impact protein function-affecting perturbations in 39 genes into 13 pathways. Progression-free (PFS) and overall survival (OS) were analysed using Kaplan–Meier curves and multivariate Cox regression models. Driver gene alterations were detected in 192/342 (56.1%) evaluable patients. An increased number of affected pathways, coined pathway complexity index (PCI), resulted in a decremental PFS and OS, and was independently associated with prognosis once ≥3 pathway or gene classes were affected (PFS HR (95%CI): 1.7 (1.02–2.84), p = 0.04, and OS HR (95%CI): 2.5 (1.06–5.71), p = 0.04). Additionally, visceral disease and baseline PSA and plasma ctDNA levels were independently associated with poor prognosis. Elevated PCI is associated with poor ARSi outcome and supports comprehensive genomic profiling to better infer mCRPC prognosis.
Additional file 4 of Continuous work-related sitting time and its association with perceived workplace support for health among workers in the Greater Accra Municipality: a cross-sectional analysis with sensitivity analyses
Creators: name: Danquah, Emelia
name: Asiamah, Nestor
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: Appendix D. steps taken at the two stages of the sensitivity analyses.
Conto-Corrent-Buch
Creators: name: Christoph Burckhardt & Co
Publisher: name: [s.n.]
Year: 1790

description: Enthält: Conti Correnti pro diversi
description: Darin: Wechselkurse (change de Naples etc.); Teile stehen Kopf zu Fuss
description: Deutsch, Französisch
description: Verzeichnung=Description=Inventaire 14.03.2017 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
[33 Ansichten von Tunis]
Creators: name: Garrigues, J.
name: Neurdein, Étienne
name: Neurdein, Antonin L.
name: C. Albert. Ph
Publisher: name: [s.n.]
Year: 1860

description: Verschiedene Aufnahmen von Tunis, darunter eine Gesamtansicht, verschiende Strassenszenen sowie mehrere Abzüge von Innenräumen.
description: Intérieur de la Grande Mosquée à Kairouan
description: Chaire de la Grand Mosquée à Kairouan
description: Lustre de la grande mosquée à Kairouan
description: Courde de la Mosquée du Barbier
description: Vue de Kairouan
description: Mosquée des Sabres à Kairouan
description: Cour de la Grande Mosquée à Kairouan
description: El Djem
description: El Djem.- Vue de l'Amphithéâtre, côte de la brèche
description: Entrée des citernes de Carthage
description: Intérieur des bciternes de Carthage
description: La Goulette
description: Oudena
description: [Wasserleitung von Oudena]
description: [Stare [unleserlich] und Bab Djebli]
description: [Stare]
description: Sousse. - Vue Générale
description: 6209. P.Z.- Sousse
description: Sousse. - La Gare du Decauville de Kairouan
description: [Tunis]
description: Porte de Bab-Djedid
description: Intérieur des Souks (bazars)
description: Le Bardo
description: Escalier dees lious au Bardo
description: Salle du trône au Bardo
description: Salle de psychés (Dar-el-Bey)
description: Lit du Bey à Kassar-Saïd
description: Façade du palais du Bey (La Marsa)
description: [Tunis. Thüre eines reichen Hauses]
description: Intérieur d'une maison arabe, Tunis
description: Cinretiere des Beys
description: Aquedue romain (route de Zaghouan)
description: J. Garrigues ; [und weitere]
description: Nicht alle Fotografien können einem Urheber zugeschrieben werden
description: Mit handschriftlicher Notiz auf der Rückseite der Unterlage; die Jahreszahlen wurden zu einem späteren Zeitpunkt notiert
description: Die Abzüge sind auf Karton montiert
description: 23 Fotografien stammen von J. Garrigues, 2 von den Gebürdern Neurdein sowie ein Abzug von C. Albert - die übrigen 9 Aufnahmen stammen von einem unbekannten Fotograf
description: Digitalisierung=Digitization=Numérisation 2024 TIFF
Brief an Amandus Polanus von Polansdorf
Creators: name: Jonas, Johannes
Publisher: name: [s.n.]
Year: 1592

description: von Jo[hannes] Jonas
description: Abschrift: UB Basel, G2 II 32:Bl.82-85r
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2018 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis, Briefkatalog und Original
Empirical Models for Correlation of Clearness Index with Cloud Index at Rutba, Iraq State.pdf
Creators: name: Majeed, Dr. Amani
Publisher: name: figshare
Year: 2022
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 91307 Numerical Modelling and Mechanical Characterisation

description: In this study, the monthly average daily values of global solar radiation and relative sunshine hours global solar radiation on a horizontal surface over a period of five years (2004-2008) using multi-linear polynomial form of the Angstrom-Prescott model have been developed to estimate global solar radiation for Rutba (one of west Iraqi cities) which lies on latitude 30°03'N and longitude 40o28' E. It was found that the five different mathematical correlations models ( first order, second order, exponential, powered, and logarithmic ) utilizing relative sunshine hours gave the best overall estimate of the total solar radiation in Rutba. The agreement between the measured values (that obtained from the archives of Iraqi meteorological office) and the computed values is remarkable and the models are recommended for use in Rutba.
Additional file 5 of Continuous work-related sitting time and its association with perceived workplace support for health among workers in the Greater Accra Municipality: a cross-sectional analysis with sensitivity analyses
Creators: name: Danquah, Emelia
name: Asiamah, Nestor
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: Appendix E. STROBE Statement—checklist of items that should be included in reports of observational studies.
Violence and mental illness: harsh reality demands sensitive answers
Creators: name: Purcell, Rosemary
name: Ogloff, James
Publisher: name: Swinburne
Year: 2024

description: The violent and senseless death of 11-year-old Luke Batty in Victoria has not only drawn attention to the serious problem of family violence but has also raised questions about the role that undiagnosed or untreated mental illness may have played in his father's behaviour. The relationship between violence and mental illness is a vexed and contentious issue. The vast majority of people experiencing mental illness are not violent. However, those with a serious mental illness have increased rates of violence, including family violence, when compared to people who do not have a mental illness.
Additional file 1 of Assessing the contributions of gender, clinical symptoms, and psychometric traits to non-suicidal self-injury behaviors in Chinese adolescents: a nomogram approach
Creators: name: Shen, Guanghui
name: Li, Cheng-Han
name: Ruan, Qian-Nan
name: Xu, Su
name: Yan, Wen-Jing
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary file1 (DOCX 762 KB)
title: Caractérisation de matériaux de stockage thermique par bilan entropique : analyse des irréversibilités et mesure des propriétés.
Creators: name: Olivès, Régis
name: Mancaux, Jean-Marie
Publisher: name: Société Française de Thermique
Year: 2024
Subjects: Stockage thermique
Bilan entropique
Sollicitation dynamique

description: Le stockage thermique repose sur la sollicitation dynamique de matériaux, c'est-à-dire une succession de phases de charge et de décharge. Afin d'évaluer les performances du module de stockage, il est donc nécessaire de déterminer les propriétés des matériaux en régime dynamique. Or, le bilan énergétique n'apporte d'information que sur l'isolation du module et non sur les performances du matériau de stockage. Ce qui semble plus intéressant est donc l'étude du bilan entropique qui renseigne sur les irréversibilités et donc conduit à la possibilité de définir un rendement exergétique du stockage. Partant de ce constat, nous basons la caractérisation du matériau sur l'analyse entropique [1]. La résolution de l'équation de bilan entropique peut conduire à l'identification de propriétés thermophysiques. L'étude des irréversibilités et de la production d'entropie lors du transfert par conduction permet de déterminer par exemple l'effusivité d'un matériau soumis à une sollicitation dynamique [2]. La méthode expérimentale consiste en la mesure et le traitement des températures superficielles et des flux de chaleur. Ainsi, le banc expérimental est constitué d'une résistance chauffante qui impose un flux de chaleur à un échantillon. Un capteur planaire, placé entre la résistance et l'échantillon mesure à la fois le flux et la température. On obtient ainsi le flux entropique à la surface de l'échantillon. La résolution de l'équation de bilan entropique peut conduire dans certains cas à une expression analytique reliant l'effusivité à l'intégrale sur le temps du flux entropique. Des mesures sont effectuées sur différents matériaux. Les solutions analytiques et des simulations numériques sont comparées aux résultats expérimentaux. Références [1] Olivès R., Mancaux J.-M. Détermination et analyse des irréversibilités dans des matériaux hétérogènes soumis à des sollicitations thermiques dynamiques. Congrès SFT, Nantes, 2019 [2] Bartoli C. Analysis of thermal irreversibilities in a homogeneous and isotropic solid. International Journal of Thermal Sciences 44, 2005.
Easy access, interactive exploration and analysis of public gene expression datasets with Phantasus
Creators: name: Sergushichev, Alexey
Publisher: name: Zenodo
Year: 2024

description: Transcriptomic profiling became a standard approach to quantify a cell state, which led to accumulation of huge amounts of public gene expression datasets. However, reuse of these datasets is inhibited by the lack of uniform format of how such data is deposited. This leads to the situation when actually getting the data ready for analysis requires many steps such as loading the gene expression values, feature and sample annotation, normalization, quality check and outlier filtering. Here we present Phantasus – a user-friendly web application for interactive gene expression analysis which provides streamlined access to almost 120,000 public gene expression datasets from Gene Expression Omnibus. Importantly, Phantasus supports both public microarray and RNA-seq datasets as quantified by ARCHS4 and DEE2 projects. With Phantasus, researchers can quickly and easily perform quality checks and analysis through its intuitive and highly interactive JavaScript user interface integrated with opencpu-based R backend. Phantasus is available at https://alserglab.wustl.edu/phantasus as well as the Bioconductor R package (https://bioconductor.org/packages/phantasus). We further provide a lightweight phantasusLite package (https://bioconductor.org/packages/devel/bioc/html/phantasusLite.html) featuring helper R functions for working with public datasets, in particular providing an access for RNA-seq counts stored at the remote HSDS (Highly Scalable Data Service) server.
Additional file 1 of Development of a whole-cell SELEX process to select species-specific aptamers against Aspergillus niger
Creators: name: Ellena, Valeria
name: Ioannou, Alexandra
name: Kolm, Claudia
name: Farnleiter, Andreas H.
name: Steiger, Matthias G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1.
Supplementary tables, figures and methods from The emergence of supergenes from inversions in Atlantic salmon
Creators: name: Stenlokk, Kristina
name: Saitou, Marie
name: Rud-Johansen, Live
name: Nome, Torfinn
name: Moser, Michel
name: Arnyasi, Mariann
name: Kent, Matthew
name: Barson, Nicola Jane
name: Lien, Sigbjorn
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Developmental Biology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics
subject: FOS: Biological sciences

description: Supplementary tables, figures and methods
From the exposome to mechanistic understanding of chemical-induced adverse effects
Creators: name: Escher, Beate I.
name: Hackemüller, Jörg
name: Polte, Tobias
name: Eisenträger, Adolf
name: Walter-Rohde, Susanne
Publisher: name: My University
Year: 2017
Subjects: Risikoanalyse

description: The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistic understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. Quelle: Verlagsinformation
Spike sorting pipeline for the International Brain Laboratory
Creators: name: Laboratory, International Brain
Publisher: name: figshare
Year: 2022
Subjects: subject: Neuroscience
subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this article, we document our current spike sorting processing pipeline, including several modifications that enable more scalable and robust processing. We also document our newly developed tools for visualizing and quality-scoring the output of each stage of the processing pipeline. We close by discussing known issues in our pipeline that present opportunities for further improvements.
Additional file 1 of Community-based participatory research (CBPR) approaches in vaccination promotion: a scoping review
Creators: name: Zhang, Yan
name: Xie, Yao Jie
name: Yang, Lin
name: Cheung, Kin
name: Zhang, Qingpeng
name: Li, Yan
name: Hao, Chun
name: Wang, Harry HX
name: Zhou, Qianling
name: Leung, Angela Yee Man
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1
Please un-do 'booty' pop videos
Creators: name: Tunstall, Elizabeth Dori
Publisher: name: Swinburne
Year: 2024

description: Dear Music Industrial Complex, Do you mind if I call you Mic? I normally don't write about pop music, but I am upset. I know that sex sells, but may I make a special request of no more music videos consisting of purely women's undulating butts? In 2014 alone, I have been subjected to the waxed and oiled derrieres of Beyoncé in all but two of her 14 videos released this year, of Rihanna and Shakira in I Can't Remember to Forget You, of Nicki Minaj in Anaconda, and now of Jennifer Lopez and Iggy Azalea in their Booty video. When the venerable New York Times is writing about butts, the butt needs to stop here.
A rapid and highly sensitive HILIC-HPLC based analytical assay method for quantification of azacitidine and venetoclax in a single run
Creators: name: More, Dnyaneshwar
name: Khan, Nasir
name: Sengupta, Pinaki
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Venetoclax and Azacitidine combination has recently been approved by the USFDA to treat old people with acute myeloid leukemia. Pharmaceutical formulations of the combination of these two drugs are expected to be launched soon. Till date, an analytical method of any type has not been reported in literature for quantification of Venetoclax and Azacitidine in a single run. The current work set out to establish an HILIC-HPLC based analytical assay method for simultaneous quantification of Azacitidine and Venetoclax from the mixed sample. The method has been developed employing Poroshell HILIC column. Ammonium formate (10 mM, pH 5.0) and acetonitrile were used as a mobile phase in gradient programme. A variety of parameters, including linearity, accuracy, precision, specificity, robustness, and ruggedness were evaluated to validate the method. Azacitidine and Venetoclax were eluted at 8.8 min and 4.0 min, respectively. Method was linear over the range of 1-100 µg/mL. Recovery was found to be 98.29-99.28% and 101.84-101.95% for Azacitidine and Venetoclax, respectively. The method was reproducible with a relative standard deviation of less than two in precision studies. The developed method can suitably be employed for quantifying Venetoclax and Azacitidine in a single run from their mixed samples.
Carphobius cupressi Wood 1974
Creators: name: Cognato, Anthony I.
name: Smith, Sarah M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Carphobius
Carphobius cupressi

description: Carphobius cupressi Wood, 1974
(Figs. 15–18, 21, 22, 24, 25)
 Carphobius cupressi Wood 1974: 12.
 Type Specimens. Holotype (NMNH) and paratypes (16 NMNH), examined.
 Diagnosis. This species is distinguished from other Carphobius by the pronotum with coarse, deep punctures spaced less than a puncture diameter apart, and larger, deeply impressed punctures on the elytral disc.
 Host. Cupressus lusitanica Mill.
 Distribution. Guatemala.
description: Published as part of Cognato, Anthony I. & Smith, Sarah M., 2023, Taxonomic Review of Carphobius Blackman, 1943 (Coleoptera: Curculionidae: Scolytinae) and a New Species from San Clemente Island, California, USA, pp. 255-263 in The Coleopterists Bulletin 77 (2) on pages 259-261, DOI: 10.1649/0010-065X-77.2.255, http://zenodo.org/record/13242980
The chromatographic determination of the lipophilicity of newly synthesized aromatic-heterocyclic carbohydrazone derivatives with potential antibacterial and antituberculosis activities
Creators: name: Hawrył, Anna
name: Swatko-Ossor, Marta
name: Hawrył, Dominika
name: Hawrył, Mirosław
name: Grabiec, Olga
name: Pitucha, Monika
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified

description: Hydrazones are a large group of compounds with antibacterial, antituberculosis, antifungal, anticonvulsant, antiviral, antiprotozoal, anticancer and anti-inflammatory properties. Ten newly synthesized hydrazones were tested for their antimicrobial and antituberculosis activities. Screening tests were performed using the disk diffusion method. Then, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration were determined for the most promising compounds. Synergy of the action of the tested substances with reference drugs was also tested. Drugs standardly used in the treatment of tuberculosis: rifampicin and isoniazid were used as reference substances. Based on the obtained results, fractional inhibitory concentration coefficients were calculated for individual combinations. The tested ones showed weak antimicrobial activity. They didn’t show either synergism of action with rifampicin and isoniazid. Then, experimental and theoretical lipophilicity parameters were determined for the obtained derivatives. The research was carried out using reversed-phase high-performance liquid chromatography (RP-HPLC), in which the mobile phase is a mixture of methanol and water. To confirm the validity of the chromatographic technique used, both experimental and calculated lipophilicity parameters were correlated. The correlation matrix of these relationships was subjected to principal component analysis (PCA).
Additional file 1 of Stable Plasmodium falciparum merozoite surface protein-1 allelic diversity despite decreasing parasitaemia in children with multiple malaria infections
Creators: name: Yaa, Reuben M.
name: Kimenyi, Kelvin M.
name: Palasciano, Henry Antonio
name: Obiero, George
name: Ochola-Oyier, L. Isabella
Publisher: name: figshare
Year: 2025
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1
Chromatographic descriptors in QSAR examination of the N, N-disubstituted chloroacetamides’ bioactivity
Creators: name: Apostolov, Suzana
name: Bogdanović, Aleksandra
name: Petrović, Slobodan
name: Vastag, Gyöngyi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: The main goal of this study was the assessment of the N, N-disubstituted-2-chloroacetamides’ biological profile by chromatographic and in silico approach. Preliminary, their drug-like as well as lead-like properties and the bioactivity scores were analyzed. By applying reversed phase thin-layer chromatography as the simulator of compound’s distribution across biological membranes, the assumed bioactivity descriptors of the studied chloroacetamides were obtained. The compliance between obtained chromatographic parameters (RM,0 m) and relevant software lipophilicity/pharmacokinetic/ecotoxicity predictors of studied derivatives were examined by linear regression and additionally supported by more detailed relations established by multivariate methods. Also, it was confirmed that the studied bioactivity properties of the given chloroacetamides are conditioned by the type of the present hydrocarbon substituents (number, arrangement and binding of C atoms).
Additional file 1 of Early behavioral indicators of aberrant feces in newly-weaned piglets
Creators: name: Witjes, Vivian L.
name: Veldkamp, Fleur
name: Velkers, Francisca C.
name: de Jong, Ingrid C.
name: Meijer, Ellen
name: Rebel, Johanna M. J.
name: Stegeman, Jan A.
name: Tobias, Tijs J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1.
Carphobius pilifer Wood 1983
Creators: name: Cognato, Anthony I.
name: Smith, Sarah M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Carphobius
Carphobius pilifer

description: Carphobius pilifer Wood, 1983
(Figs. 19, 20, 23, 26)
 Carphobius pilifer Wood 1983: 652.
 Type Specimens. Holotype (NMNH) and paratypes (2 NMNH), examined.
 Diagnosis. This species is distinguished from C. arizonicus by the long, dark setae on declivital interstriae 1 and 2.
 Host. Cupressus lindleyi Klotzsch ex Endl. (= C. lusitanica).
 Distribution. Mexico: Morelos.
 Remarks. The male is unknown.
description: Published as part of Cognato, Anthony I. & Smith, Sarah M., 2023, Taxonomic Review of Carphobius Blackman, 1943 (Coleoptera: Curculionidae: Scolytinae) and a New Species from San Clemente Island, California, USA, pp. 255-263 in The Coleopterists Bulletin 77 (2) on page 261, DOI: 10.1649/0010-065X-77.2.255, http://zenodo.org/record/13242980
Dynamical modelling of the regulatory network underlying Retinoic Acid resistance in Acute Promyelocytic Leukaemia
Creators: name: Thieffry, Denis
Publisher: name: Zenodo
Year: 2024

description: Abstract

Acute Promyelocytic Leukaemia (APL) results from an aberrant chromosomal translocation involving the Retinoic Acid Receptor Alpha (RARA) gene, predominantly with the Promyelocytic Leukaemia (PML) or Promyelocytic Leukaemia Zinc Finger (PLZF) gene. These oncoproteins block the haematopoietic differentiation program promoting aberrant proliferative promyelocytes. Retinoic Acid (RA) therapy is successful in most of the PML::RARA patients, while PLZF::RARA patients frequently become resistant and relapse. Recent studies pointed to various underlying molecular components, but their precise contributions remain to be deciphered. We developed a logical network model integrating signalling, transcriptional and epigenetic regulatory mechanisms, which captures key features of the APL cell responses to RA depending on the genetic background. The explicit inclusion of the histone methyltransferase EZH2 allowed the assessment of its role in the resistance mechanism, distinguishing between its canonical and non-canonical activities. The model dynamics was thoroughly analysed using tools integrated in the public software suite maintained by the CoLoMoTo consortium (https://colomoto.github.io/). The model serves as a solid basis to assess the roles of novel regulatory mechanisms, as well as to explore novel therapeutical approaches in silico.
Dynamical modelling of the regulatory network underlying Retinoic Acid resistance in Acute Promyelocytic Leukaemia
Creators: name: Thieffry, Denis
Publisher: name: Zenodo
Year: 2024

description: AbstractMotivation: Acute Promyelocytic Leukaemia (APL) results from an aberrant chromosomal translocation involving the Retinoic Acid Receptor Alpha (RARA) gene, predominantly with the Promyelocytic Leukaemia (PML) or Promyelocytic Leukaemia Zinc Finger (PLZF) gene. These oncoproteins block the normal haematopoietic differentiation program and promote aberrant proliferative promyelocytes. A Retinoic Acid (RA) therapy is successful in most of the PML::RARA pa- tients, while PLZF::RARA patients frequently display treatment resistance and relapse. Recent studies pointed to various underlying molecular components, but their precise contributions remain to be established.Results: We developed a logical network model integrating signalling, transcriptional and epigenetic regulatory mechanisms, which captures the key features of the APL cell responses to RA treatment depending on the genetic background. The explicit inclusion of the histone methyltransferase EZH2 allowed us to assess its role in the maintenance of the resistant phenotype, distinguishing between its canonical and non-canonical activities. The model dynamics were thoroughly analysed using a combination of tools integrated in the public software suite maintained by the CoLoMoTo consortium (https://colomoto.github.io/). All the code and results are documented in a Jupyter notebook, greatly easing the reproduction and further extensions of our analyses. Ultimately, the model serves as a solid basis to assess the roles of novel regulatory mechanisms, as well as to explore novel therapeutical approaches in silico.Availability: The model and the electronic Jupyter notebook enabling the production of all reported results can be downloaded from http://ginsim.org/node/256.Contact: elisabeth.remy@univ-amu.fr, denis.thieffry@ens.fr
Additional file 2 of Early behavioral indicators of aberrant feces in newly-weaned piglets
Creators: name: Witjes, Vivian L.
name: Veldkamp, Fleur
name: Velkers, Francisca C.
name: de Jong, Ingrid C.
name: Meijer, Ellen
name: Rebel, Johanna M. J.
name: Stegeman, Jan A.
name: Tobias, Tijs J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 2.
Numerical Study of the Effect of Orientation Angles on Combined Convection in a Cavity Contain Rotation Cylinder
Creators: name: Majeed, Dr. Amani
Publisher: name: figshare
Year: 2022
Subjects: subject: 91502 Computational Heat Transfer
subject: FOS: Other engineering and technologies
subject: 91505 Heat and Mass Transfer Operations
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: This study examines the influence of a rotating cylinder on heat transmitted by mixed convection in an air-filled square space. The appropriate mathematical models for continuous, incompressible, 2-dimensional, laminar flows with Boussinseq’s approach are solved numerically, where constant fluid properties have been used. The most important parameters examined are: the angular velocity (Ω = 0 - 1000) and the angle of inclination (Ɵ = 0 – 90o), the study has been carried out with the Rayleigh number (Ra = 104 ), the Prandtl number (Pr = 0.7). The results show that the streamlines are affected by the angular velocity, where the forced convection becomes dominant at high values of angular velocity. The rotation of the cylinder has an effect on the heat exchange between the walls of the cavity and the fluid. Finally the average Nusselt number is increased with increases of angular velocity and decreases as inclination angles change from horizontal to vertical position. A good agreement has been achieved by comparing the results of this work with other previous work
Additional file 4 of Early behavioral indicators of aberrant feces in newly-weaned piglets
Creators: name: Witjes, Vivian L.
name: Veldkamp, Fleur
name: Velkers, Francisca C.
name: de Jong, Ingrid C.
name: Meijer, Ellen
name: Rebel, Johanna M. J.
name: Stegeman, Jan A.
name: Tobias, Tijs J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 4.
Genetic development of the concepts of Mechanics and application to teaching problems
Creators: name: HALBWACHS, FRANCIS
Publisher: name: Review of Science, Mathematics and ICT Education
Year: 2025

description: Draft of paper presented in the International Conference of Science Adult Education, London, 2-4 April 1973 (typed text, retrieved from Halbwachs archives, 2024).
description: Review of Science, Mathematics and ICT Education, Vol 19, No 1 (2025): Fragments of the history of Science Education: Homage to Francis Halbwachs
Additional file 5 of Early behavioral indicators of aberrant feces in newly-weaned piglets
Creators: name: Witjes, Vivian L.
name: Veldkamp, Fleur
name: Velkers, Francisca C.
name: de Jong, Ingrid C.
name: Meijer, Ellen
name: Rebel, Johanna M. J.
name: Stegeman, Jan A.
name: Tobias, Tijs J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 5.
Some remarks on the psychological approach in Didactics
Creators: name: HALBWACHS, FRANCIS
Publisher: name: Review of Science, Mathematics and ICT Education
Year: 2025

description: Draft of a paper presented at the Workshop "Developmental Models of Thinking", Kiel, 11-14 September 1977 (typed text, retrieved from Halbwachs archives, 2024).
description: Review of Science, Mathematics and ICT Education, Vol 19, No 1 (2025): Fragments of the history of Science Education: Homage to Francis Halbwachs
Computational Study of the Electron Spectra of Vapor-Phase Indole and Four Azaindoles
Creators: name: Chong, Delano P. (Delano Pun), 1936-
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: After geometry optimization, the electron spectra of indole and four azaindoles are calculated by density functional theory. Available experimental photoemission and excitation data for indole and 7-azaindole are used to compare with the theoretical values. The results for the other azaindoles are presented as predictions to help the interpretation of experimental spectra when they become available.
Table S2 from Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals
Creators: name: Berdan, Emma L.
name: Blanckaert, Alexandre
name: Butlin, Roger K.
name: Flatt, Thomas
name: Slotte, Tanja
name: Wielstra, Ben
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Supergenes offer spectacular examples of long-term balancing selection in nature, but their origin and maintenance remain a mystery. Reduced recombination between arrangements, a critical aspect of many supergenes, protects adaptive multi-trait phenotypes but can lead to mutation accumulation. Mutation accumulation can stabilize the system through the emergence of associative overdominance (AOD), destabilize the system, or lead to new evolutionary outcomes. One outcome is the formation of maladaptive balanced lethal systems, where only heterozygotes remain viable and reproduce. We investigated the conditions under which these different outcomes occur, assuming a scenario of introgression after divergence. We found that AOD aided the invasion of a new supergene arrangement and the establishment of a polymorphism. However, this polymorphism was easily destabilized by further mutation accumulation, which was often asymmetric, disrupting the quasi-equilibrium state. Mechanisms that accelerated degeneration tended to amplify asymmetric mutation accumulation between the supergene arrangements and vice-versa. As the evolution of balanced lethal systems requires symmetric degeneration of both arrangements, this leaves only restricted conditions for their evolution, namely small population sizes and low rates of gene conversion. The dichotomy between the persistence of polymorphism and degeneration of supergene arrangements likely underlies the rarity of balanced lethal systems in nature.This article is part of the theme issue ‘Genomic architecture of supergenes: causes and evolutionary consequences’.
Supplemental Figures from Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals
Creators: name: Berdan, Emma L.
name: Blanckaert, Alexandre
name: Butlin, Roger K.
name: Flatt, Thomas
name: Slotte, Tanja
name: Wielstra, Ben
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60408 Genomics
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Supplemental Figures S1-S16
Additional file 1 of MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis
Creators: name: Xu, Chungui
name: Lin, Weihao
name: Zhang, Qi
name: Ma, Yarui
name: Wang, Xue
name: Guo, Ai
name: Zhu, Guiling
name: Zhou, Zhendiao
name: Song, Weiwei
name: Zhao, Ziyi
name: Jiao, Yuchen
name: Wang, Xiaobing
name: Du, Chunxia
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
EVALUATION OF THE INCIDENCE RATE OF GASTROESOPHAGEAL REFLUX DISEASE AMONG STUDENTS USING THE GERDQ QUESTIONNAIRE
Creators: name: Zayniyev, Sh.S.
name: Yuldasheva, D.H.
Publisher: name: Zenodo
Year: 2024

description: In this study, the prevalence of gastroesophageal reflux disease among students was investigated using the GERDQ questionnaire. 50 students of the 3rd year participated in the research. The results of the tests are based on the high incidence of gastroesophageal reflux disease among young men.
Majeed2021_Article_NumericalStudyOfTheNaturalFrac1.pdf
Creators: name: Majeed, Dr. Amani
name: Al Mukhtar, A.
Publisher: name: figshare
Year: 2022
Subjects: subject: 91406 Petroleum and Reservoir Engineering
subject: FOS: Environmental engineering

description: This paper presents an experimental and numerical study to investigate the hydrodynamics behavior of the fractured and nonfractured cores. The comparison between the simulated and experiments result is also presented. In this work, the Element Based Finite Volume Method (EbFVM) was used according to the Dual Porosity Dual PermeabilityModel (DPDP). The behavior of single-phase fluid flow in actual cores was studied for a fractured reservoir in Iraqi fields from Rumaila/Mishrif formation at different depths. ANSYS-CFX, a finite element based simulator was used to represent the pressure and velocity distributions. Therefore, the comparison between a fractured core and a nonfractured core was performed. The representation of fluid flow behavior in a fractured reservoir was presented. It is found that the presence of cracks increase the percentage of improvement in the productivity index to reach about (6.59% and 10.46%) for Rumaila core 14 and Rumaila core 15, respectively.
Majeed2021_Article_NumericalStudyOfTheNaturalFrac1.pdf
Creators: name: Majeed, Dr. Amani
Publisher: name: figshare
Year: 2022
Subjects: subject: 91406 Petroleum and Reservoir Engineering
subject: FOS: Environmental engineering

description: This paper presents an experimental and numerical study to investigate the hydrodynamics behavior of the fractured and nonfractured cores. The comparison between the simulated and experiments result is also presented. In this work, the Element Based Finite Volume Method (EbFVM) was used according to the Dual Porosity Dual PermeabilityModel (DPDP). The behavior of single-phase fluid flow in actual cores was studied for a fractured reservoir in Iraqi fields from Rumaila/Mishrif formation at different depths. ANSYS-CFX, a finite element based simulator was used to represent the pressure and velocity distributions. Therefore, the comparison between a fractured core and a nonfractured core was performed. The representation of fluid flow behavior in a fractured reservoir was presented. It is found that the presence of cracks increase the percentage of improvement in the productivity index to reach about (6.59% and 10.46%) for Rumaila core 14 and Rumaila core 15, respectively.
Fracturing Parameters in Petroleum.pdf
Creators: name: Majeed, Dr. Amani
name: Al Mukhtar, A.
Publisher: name: figshare
Year: 2022
Subjects: subject: 91406 Petroleum and Reservoir Engineering
subject: FOS: Environmental engineering
subject: 40309 Petroleum and Coal Geology
subject: FOS: Earth and related environmental sciences

description: The increasing demand for crude oil makes it necessary to consider factors that increase the productivity of the reservoirs. One of these factors is fracture that is found naturally or produced hydraulically, where the fracture improves reservoir flow and connectivity. The most common characteristics of naturally fractured reservoirs (NFRs) are the fractures directionality. In this review, the most important characteristics and parameters that affect the fracture have been explained. In addition, the simulations of the fracture phenomena have been cleared. The difference among the models that solved the fracture problems are; discrete fracture model (DFM), dual porosity model (DPM), embedded discrete fracture model (EDFM), and hybrid models DP and EDFM (DP + EDFM) are shown with characteristics of each model. The present study focused on the shape factor and the direction of the fracture to show their effects on the performance of the petroleum reservoir. In addition, the review of general important parameters for the fractured reservoirs has been presented.
Fracturing Parameters in Petroleum.pdf
Creators: name: Majeed, Dr. Amani
Publisher: name: figshare
Year: 2022
Subjects: subject: 91406 Petroleum and Reservoir Engineering
subject: FOS: Environmental engineering
subject: 40309 Petroleum and Coal Geology
subject: FOS: Earth and related environmental sciences

description: The increasing demand for crude oil makes it necessary to consider factors that increase the productivity of the reservoirs. One of these factors is fracture that is found naturally or produced hydraulically, where the fracture improves reservoir flow and connectivity. The most common characteristics of naturally fractured reservoirs (NFRs) are the fractures directionality. In this review, the most important characteristics and parameters that affect the fracture have been explained. In addition, the simulations of the fracture phenomena have been cleared. The difference among the models that solved the fracture problems are; discrete fracture model (DFM), dual porosity model (DPM), embedded discrete fracture model (EDFM), and hybrid models DP and EDFM (DP + EDFM) are shown with characteristics of each model. The present study focused on the shape factor and the direction of the fracture to show their effects on the performance of the petroleum reservoir. In addition, the review of general important parameters for the fractured reservoirs has been presented.
Additional file 6 of Early behavioral indicators of aberrant feces in newly-weaned piglets
Creators: name: Witjes, Vivian L.
name: Veldkamp, Fleur
name: Velkers, Francisca C.
name: de Jong, Ingrid C.
name: Meijer, Ellen
name: Rebel, Johanna M. J.
name: Stegeman, Jan A.
name: Tobias, Tijs J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 6.
title: Local blood flow analysis and visualization from RGB-video sequences
Creators: name: Kossack, Benjamin
name: Wisotzky, Eric L.
name: Hilsmann, Anna
name: Eisert, Peter
name: Hänsch, Ronny
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: Blood flow
subject: remote photoplethysmography
subject: cardiovascular
subject: heart rate
subject: pulse transit time
subject: 570 Biologie

description: The extraction of heart rate and other vital parameters from video recordings of a person has attracted much attention over the last years. In this paper, we examine time differences between distinct spatial regions using remote photoplethysmography (rPPG) in order to extract the blood flow path through human skin tissue in the neck and face. We can show that the visualization of the blood flow path corresponds to the physiologically defined path.
Electronic stability control for electric vehicle with 4 in-wheel electric motor
Creators: name: Hasan, Muhammad Mehedi Al Emran
Publisher: name: Swinburne
Year: 2024

description: Recently, electric vehicles are becoming increasingly the better option in reducing environmental pollution relative to other fuel based vehicles. An advanced electric vehicle is considered in this research to improve vehicle stability. The idea of using in-wheel motor was implemented which reduced car weight and allowed for flexibility in controlling the vehicle stability. A vehicle model based advanced control technique was analysed and implemented to calculate and maintained individual wheel torque for vehicle stability. This research offers a simplified and effective vehicle active safety system for accident prevention.
Additional file 1 of Impact of standard precautions and unrestricted movements of carbapenemase-producing Enterobacterales (CPE) carriers on CPE transmission in a nursing home in Singapore: a prospective cohort study
Creators: name: Linn, Kyaw Zaw
name: Huan, Xiaowei
name: Hon, Pei Yun
name: Husen, Sharifah Farhanah Syed
name: Thevasagayam, Natascha May
name: Ng, Oon Tek
name: Vasoo, Shawn
name: Ling, Moi Lin
name: Fisher, Dale
name: Marimuthu, Kalisvar
Publisher: name: figshare
Year: 2025
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
Additional file 7 of Early behavioral indicators of aberrant feces in newly-weaned piglets
Creators: name: Witjes, Vivian L.
name: Veldkamp, Fleur
name: Velkers, Francisca C.
name: de Jong, Ingrid C.
name: Meijer, Ellen
name: Rebel, Johanna M. J.
name: Stegeman, Jan A.
name: Tobias, Tijs J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 7.
title: Surgical Phase Recognition for different hospitals
Creators: name: Wisotzky, Eric L.
name: Renz-Kiefel, Lasse
name: Beckmann, Sophie
name: Lünse, Sebastian
name: Mantke, René
name: Hilsmann, Anna
name: Eisert, Peter
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Phase Recognition
subject: Surgical Phase
subject: Temporal Convolutional Network
subject: Cholecystectomy
subject: Laparoscopic Surgery
subject: 570 Biologie

description: Surgical phase recognition is an important aspect of surgical workflow analysis, as it allows an automatic analysis of the performance and efficiency of surgical procedures. A big challenge for training a neural network for surgical phase recognition is the availability of training data and the large (visual) variability in procedures of different surgeons. Hence, a network must be able to generalize to new data. In this paper, we present an adaptation of a Temporal Convolutional Network for surgical phase recognition in order to ensure the generalization of the network to new scenes with different conditions on the example of cholecystectomy. We used publicly available datasets of 104 surgeries from four different centers for training. The results showed that the network was able to generalize to new scenes and we obtained recognition results with accuracy up to 82% on our own six captured surgeries, performed in a different hospital. This performance is similar for test data from the hospitals of the training data, suggesting that the network can well generalize to new surgical rooms and surgeons. The findings have important implications for the development of automated surgical decision support systems that can be applied in a variety of real-world surgical settings.