cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
E02449: Gregory of Tours, in his Glory of the Confessors (1), recounts a miracle of drink that never runs dry, after a man invokes the names of the *Angels (S00723) on an estate in the territory of Clermont (central Gaul); episode datable to before 573. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 1

The lord of an estate tells Gregory, then living in the territory of Clermont, about a miracle performed by angels. He ordered his servants to prepare caelia (a drink brewed from grain soaked and boiled in water) for the reapers gathered to cut his corn, but they drank almost everything before the work began, so he was afraid the drink would run out.

Tandem, inspirante Domino, conversus ad vasculum, nomina angelorum sanctorum, quae sacrae docent lectiones, super aditum eius devote invocat, orans, ut virtus eorum pario vitatem hanc in abundantiam convertere dignaretur, ne operaiis defeceret quod haurirent. Mirum dictu! Tota die ab hoc extractum numquam defuit bibentibus, sed, usque quod nox finem operandi fecit, omnibus fuit in abundantia ministratum.

'Finally, with the inspiration of the Lord he turned to the container and piously recited over its mouth the names of the holy angels that the sacred readings taught (quae sacrae docent lectiones). He prayed that their power deign to transform this pittance into an abundance, that the workers would not lack something to drink. Wonderful to relate! Throughout the entire day drinkers never lacked [drink] drawn from this container. Until nightfall ended work, drink was served in abundance to everyone.'

Text: Krusch 1969, 298-299. Translation: Van Dam 2004, 2-3, lightly modified.
sj-pdf-5-nnr-10.1177_1545968320981942 – Supplemental material for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial
Creators: name: Maijke Van Bloemendaal
name: Bus, Sicco A.
name: Nollet, Frans
name: Geurts, Alexander C. H.
name: Beelen, Anita
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, sj-pdf-5-nnr-10.1177_1545968320981942 for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial by Maijke van Bloemendaal, Sicco A. Bus, Frans Nollet, Alexander C. H. Geurts and Anita Beelen in Neurorehabilitation and Neural Repair
Additional file 21 of Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Creators: name: Martirosyan, Araks
name: Ansari, Rizwan
name: Pestana, Francisco
name: Hebestreit, Katja
name: Gasparyan, Hayk
name: Aleksanyan, Razmik
name: Hnatova, Silvia
name: Poovathingal, Suresh
name: Marneffe, Catherine
name: Thal, Dietmar R.
name: Kottick, Andrew
name: Hanson-Smith, Victor J.
name: Guelfi, Sebastian
name: Plumbly, William
name: Belgard, T. Grant
name: Metzakopian, Emmanouil
name: Holt, Matthew G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 21: Supplementary Figure 11. TH expression across subpopulations. Violin plots showing the SCT-normalized expression of tyrosine hydroxylase (TH) across subpopulations of neurons, astrocytes, microglia and oligodendrocytes.
Der Einzelmensch in den sozialen Kundgebungen Pius' XII.
Creators: name: Leiber SJ, Robert
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013
Subjects: Mensch; Individuum; Lehre; Papst; Pius XII.; Verkündigung; Person; Leben; Recht; Arbeit; Gesellschaft; Macht; Staat; Wirtschaft; Würde; Materialismus; Gefahr

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 3 (1962): Jahrbuch für Christliche Sozialwissenschaften 03 (1962)
sj-pdf-6-nnr-10.1177_1545968320981942 – Supplemental material for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial
Creators: name: Maijke Van Bloemendaal
name: Bus, Sicco A.
name: Nollet, Frans
name: Geurts, Alexander C. H.
name: Beelen, Anita
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, sj-pdf-6-nnr-10.1177_1545968320981942 for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial by Maijke van Bloemendaal, Sicco A. Bus, Frans Nollet, Alexander C. H. Geurts and Anita Beelen in Neurorehabilitation and Neural Repair
Zellen, Verbände, Kirche
Creators: name: Paulus, Josef
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013
Subjects: Zelle; Verband; Kirche; Katholizismus; Deutschland; Seelsorge; Gemeinschaft; Bildung; Soziologie; Sozialismus; Arbeit; Caritas

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 3 (1962): Jahrbuch für Christliche Sozialwissenschaften 03 (1962)
sj-pdf-1-sjp-10.1177_1403494820984026 – Supplemental material for COVID-19 among immigrants in Norway, notified infections, related hospitalizations and associated mortality: A register-based study
Creators: name: Indseth, Thor
name: Grøsland, Mari
name: Arnesen, Trude
name: Skyrud, Katrine
name: Kløvstad, Hilde
name: Veneti Lamprini
name: Telle, Kjetil
name: Kjøllesdal, Marte
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-sjp-10.1177_1403494820984026 for COVID-19 among immigrants in Norway, notified infections, related hospitalizations and associated mortality: A register-based study by Thor Indseth, Mari Grøsland, Trude Arnesen, Katrine Skyrud, Hilde Kløvstad, Veneti Lamprini, Kjetil Telle and Marte Kjøllesdal in Scandinavian Journal of Public Health
sj-pdf-1-eqs-10.1177_8755293020981995 – Supplemental material for A frequency-dependent ground-motion spatial correlation model of within-event residuals for Fourier amplitude spectra
Creators: name: Wang, Nan
name: Olsen, Kim B
name: Day, Steven M
Publisher: name: SAGE Journals
Year: 2021
Subjects: Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-eqs-10.1177_8755293020981995 for A frequency-dependent ground-motion spatial correlation model of within-event residuals for Fourier amplitude spectra by Nan Wang, Kim B Olsen and Steven M Day in Earthquake Spectra
Die acht Grundgestalten des Lebensweges im Spannungsfeld von Familie und Berufsbereich
Creators: name: Heinen, Wilhelm
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2013
Subjects: Familie; Leben; Spannung; Beruf; Ehe; Gemeinschaft; Leben; Person; Arbeit; Reifung; Prozess

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 5 (1964): Jahrbuch für Christliche Sozialwissenschaften 05 (1964)
sj-pdf-1-wmr-10.1177_0734242X20982060.pdf – Supplemental material for Environmentally friendly automated line for recovering aluminium and lithium iron phosphate components of spent lithium-iron phosphate batteries
Creators: name: Haijun Bi
name: Huabing Zhu
name: Jialin Zhan
name: Zu, Lei
name: Yuxuan Bai
name: Huabing Li
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-wmr-10.1177_0734242X20982060.pdf for Environmentally friendly automated line for recovering aluminium and lithium iron phosphate components of spent lithium-iron phosphate batteries by Haijun Bi, Huabing Zhu, Jialin Zhan, Lei Zu, Yuxuan Bai and Huabing Li in Waste Management & Research
Additional file 1 of Defense Responses of Different Rice Varieties Affect Growth Performance and Food Utilization of Cnaphalocrocis medinalis Larvae
Creators: name: Zhao, Xiaoyu
name: Xu, Hongxing
name: Yang, Yajun
name: Sun, Tianyi
name: Ullah, Farman
name: Zhu, Pingyang
name: Lu, Yanhui
name: Huang, Jianlei
name: Wang, Zhengliang
name: Lu, Zhongxian
name: Guo, Jiawen
Publisher: name: figshare
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Additional File 1: Supplementary Figure S1. The leaf rolling rate of C. medinalis on three rice varieties
Sozialer Katholizismus und demokratischer Wohlfahrtsstaat. Klärungsversuche zur Geschichte und Gegenwart einer ungewollten Wahlverwandtschaft
Creators: name: Große Kracht, Hermann-Josef
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Wohlfahrt; Politik; Wohlstand; Geschichte; Liberalismus; Katholizismus; Demokratie; Freiheit; Gleichheit; Recht; Moderne

description: Sozialer Katholizismus und demokratischer Wohlfahrtsstaat. Klärungsversuche zur Geschichte und Gegenwart einer ungewollten Wahlverwandtschaft
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 46 (2005): Europäische Wohlfahrtsstaatlichkeit. Soziokulturelle Grundlagen und religiöse Wurzeln
Körperlichkeit – Gesundheit – gutes Leben. Zur Begründung einer allgemeinen Gesundheitsversorgung aus der Perspektive des Capabilities approach
Creators: name: Winkler, Katja
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2006
Subjects: Gesundheit; Politik; Gesundheitspolitik; Anthropologie; Gerechtigkeit; Ethik; Liberalismus; Utilitarismus; Verantwortung

description: Der Capabilities approach geht davon aus, dass es unmöglich ist, Sozialpolitik ohne eine Vorstellung von Humanität zu gestalten. Deshalb stehen die Bedingungen des Menschseins und dessen Zwecke im Mittelpunkt der Gerechtigkeitstheorie des Fähigkeitenansatzes, die systematisch drei Ebenen umfasst: Auf anthropologischer Grundlage (Ebene 1) wird eine allgemeine, aber deutungsoffene Konzeption des Guten (Ebene 2) als gerechtigkeitstheoretische Zielvorstellung ermittelt, aus der sich gewisse politische Aufgaben (Ebene 3) ergeben. Die Theorie des Guten ist aus freiheitsrelevanten Gründen in Form von Grundfähigkeiten formuliert, wobei eine davon die Fähigkeit ist, sich guter Gesundheit zu erfreuen. Aus dieser Grundfähigkeit ergibt sich die politische Forderung, ein öffentliches Gesundheitswesen zu etablieren und nach dem Kriterium der Befähigung zum guten, und das heißt selbstbestimmten, Leben zu gestalten. Der Capabilities approach bietet einerseits eine plausible ethische Begründungsmöglichkeit des Menschenrechts auf Gesundheit und andererseits an Grundfähigkeiten orientierte Kriterien für die gerechte Gestaltung der Rahmenordnung eines Gesundheitssystems. Die Ethik des Fähigkeitenansatzes setzt sich mit einem Rückgriff auf die klassisch-naturrechtliche Argumentationsform von liberalen und utilitaristischen Theorien ab und versucht eine sozialethische Position zu formulieren, in der es um die Befähigung zum konkreten eigenverantwortlichen Leben geht.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 47 (2006): Gesundheit – Ethik – Politik. Sozialethik der Gesundheitsversorgung
Einheitliche Gesundheitsversorgung oder Basisabsicherung mit privater Zusatzversicherung? Grundzüge einer Ethik des Gesundheitswesens
Creators: name: Bobbert, Monika
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2006
Subjects: Gesundheit; Versicherung; Deutschland; Verantwortung; Liberalismus; Recht; Solidarität; Kultur

description: Vor dem Hintergrund der Finanzierungskrise der Gesetzlichen Krankenversicherung wird zunehmend die Frage diskutiert, ob eine öffentliche Gesundheitsversorgung wirklich immer umfassenden Charakter haben muss, oder ob nicht eine allgemeine, öffentlich garantierte Basisversorgung genügt, über die hinaus jede Einzelperson nach Maßgabe ihrer Bereitschaft und finanziellen Möglichkeiten selbst private Zusatzversicherungen abschließen muss, um für sich eine umfassendere Gesundheitsversorgung zu gewährleisten. Häufig wird die letztgenannte Auffassung aus dem liberalen Spektrum der politischen Philosophie heraus vertreten. Auch der vorliegende Beitrag geht von einer liberalen Grundkonzeption – von dem in der Tradition Kants stehenden Ansatz des US-amerikanischen Ethikers Alan Gewirth – aus, kommt aber zu dem Ergebnis, dass zur Realisierung der Bedingungen der Handlungsfähigkeit der Menschen eine umfassende allgemeine Gesundheitsversorgung notwendig ist. Er zeigt, wie sich Rechte auf Hilfeleistungen durch andere begründet fordern lassen. Schwerpunkt des Beitrags bilden aber nicht Begründungs-, sondern Anwendungsfragen: Etwa die gegenwärtig diskutierten Fragen der Prioritätensetzung in der Versorgung, des Selbstbestimmungsrechts, der Gesundheitsprävention und eines entsprechenden Anreizsystems oder der Überprüfung institutioneller Strukturen auf ihre Legitimität hin. Obwohl es im Wesentlichen um das Recht auf eine umfassende Gesundheitsversorgung geht, wird schließlich die Notwendigkeit einer gesellschaftlichen Kultur des Helfens betont.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 47 (2006): Gesundheit – Ethik – Politik. Sozialethik der Gesundheitsversorgung
Additional file 1 of Bioindication for Ecosystem Regeneration towards Natural conditions: the BERN data base and BERN model
Creators: name: Schlutow, Angela
name: Kraft, Philipp
name: Scheuschner, Thomas
name: Schlutow, Mark
name: Schröder, Winfried
Publisher: name: figshare
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 1: Table S1. Comparison of measured and modelled value ranges for pH-values (pH), and C/N ratio (CN).
Globale Solidarität mit den Armen
Creators: name: Mack, Elke
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2007
Subjects: Solidarität; Armut; Markt; Institution; Ordnung; Rahmen; Entwicklung; Gerechtigkeit; Kosmopolitanismus; Liebe

description: Zum ersten Mal in der Geschichte der Menschheit besteht die reale Möglichkeit, durch globale Solidarität die absolute Armut in weiten Teilen der Welt signifikant zu lindern. Der Beitrag prüft und diskutiert aus christlich-sozialethischer Perspektive drei Instrumente der Armutsbekämpfung, nämlich Märkte, Solidarität und Institutionen auf nationaler und internationaler Ebene. Märkte bieten – sofern faire Rahmenbedingungen gewährleistet sind – für die Einzelnen wie für die Entwicklungsländer als ganze die Chance zur eigenverantwortlichen Wohlstandssicherung. Sie bedürfen aber der Ergänzung durch Maßnahmen der Solidarität, die im Beitrag erläutert werden. Transnationale Strukturen politischer Gerechtigkeit bilden schließlich den notwendigen institutionellen Rahmen für die Selbstentwicklung aus Armut. Den theologisch-heuristischen Rahmen für eine globale Theorie der Gerechtigkeit bildet ein subsidiärer Kosmopolitanismus, der jeden Menschen gleichermaßen zum Subjekt der Liebe macht.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 48 (2007): Solidarität
Zur Lage des wissenschaftlichen Nachwuchses in der katholischen Theologie: Forschungsbericht
Creators: name: Gabriel, Karl
name: Schönhöffer, Peter
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2007

description: Zur Lage des wissenschaftlichen Nachwuchses in der katholischen Theologie: Forschungsbericht
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 48 (2007): Solidarität
„Mittendrin und nicht dabei?“ Beteiligung, Inklusion und Integration in modernen Gesellschaften Bericht zum 16. Forum Sozialethik (11. bis 13.09.2006 in der Kommende, Dortmund)
Creators: name: Eckstein, Christiane
name: Filipović, Alexander
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2007

description: „Mittendrin und nicht dabei?“ Beteiligung, Inklusion und Integration in modernen Gesellschaften Bericht zum 16. Forum Sozialethik (11. bis 13.09.2006 in der Kommende, Dortmund)
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 48 (2007): Solidarität
Supplemental Material, sj-pdf-1-cll-10.1177_0963689720970456 - Intravenously Injected Pluripotent Stem Cell–derived Cells Form Fetomaternal Vasculature and Prevent Miscarriage in Mouse
Creators: name: Daimon, Atsushi
name: Morihara, Hirofumi
name: Kiichiro Tomoda
name: Morita, Natsuko
name: Koishi, Yoshinori
name: Kanki, Kazuyoshi
name: Ohmichi, Masahide
name: Asahi, Michio
Publisher: name: SAGE Journals
Year: 2020
Subjects: Medicine
Cell Biology

description: Supplemental Material, sj-pdf-1-cll-10.1177_0963689720970456 for Intravenously Injected Pluripotent Stem Cell–derived Cells Form Fetomaternal Vasculature and Prevent Miscarriage in Mouse by Atsushi Daimon, Hirofumi Morihara, Kiichiro Tomoda, Natsuko Morita, Yoshinori Koishi, Kazuyoshi Kanki, Masahide Ohmichi and Michio Asahi in Cell Transplantation
Mitteilungen aus der deutschsprachigen Sozialethik: Aktuelle Projekte
Creators: name: Gabriel, Karl
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2007

description: Mitteilungen aus der deutschsprachigen Sozialethik: Aktuelle Projekte
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 48 (2007): Solidarität
Wandel von Lebensverlaufsmustern – Herausforderungen für politisches Handeln
Creators: name: Wippermann, Carsten
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Milieus; Lebenslagen, Lebenslauf, Politik, Sozialpolitik

description: Zusammenfassung
Der unabgeschlossene Modernisierungs­prozess der Individualisierung hat zu einer Vielzahl perforierter Lebensverläufe und disparater Normalbiographien mit je eigener Logik geführt. Die Risiken dieser neuen und alten Lebenslaufregime treffen Frauen und Männer, die verschiedenen Generationen sowie die sozialen Milieus nicht in gleichem Maße. Zugleich sind die materiellen, sozialen und kulturellen Ressourcen und daraus resultierend die paradigmatischen Lebensverlaufsperspektiven sowie die Bereitschaften und Möglichkeiten zur Verantwortung in den Milieus sehr unterschiedlich. Das hat Konsequenzen für die Bewältigung der Haupt-, Neben- und Spätfolgen. Damit steht die Politik vor der Herausforderung der Gleichzeitigkeit des Ungleichzeitigen: Die veränderten und sich dynamisch weiter verändernden Realitäten zur Grundlage politischer Entscheidungen und Visionen zu machen. Das erfordert Multiperspektivität und verweist umso dringender auf Institutionalisierung (von Verfahrensweisen) einer konsistenten und konzertierten Politik statt primär eigenlogisch-abgeschlossen operierender Ressorts. Das zielt auf Reflexion der konkreten (!) Konsequenzen für die verschiedenen Zielgruppen in ihren aktuellen und weiteren Phasen im Lebenslauf. Nach Maßgabe der Milieu-, Generationen- und Geschlechtergerechtigkeit wäre ein naheliegendes politisches Prinzip das der Ermöglichung und Aufklärung.

Abstract
The incomplete modern process of individualisation has led to a multiplicity of perforated lives and disparate standard biographies each following their own internal logic. The risks of these new and old life-course regimes do not affect men and women, the different generations or the different milieus to the same extent. At the same time, material, social, and cultural resources and the resulting paradigmatic life-course perspectives, and the willingness and possibilities to accept responsibility vastly differ depending on milieu. This of course has a great bearing on the handling of main, indirect, and late consequences. Hence, politics face the simultaneity of the nonsimultaneous: the challenge of making changed and dynamically further changing reality the basis of political decisions and ideas. This requires multiperspectivity and the urgent institutionalisation (of procedures) of consistent and focussed politics instead of departments locked in their primarily self-referential logics. This aims at considering the concrete (!) consequences for the different target groups in their current and further life-course phases. Taking milieu, generation and gender justice seriously, one political principle that offers itself is that of enablement and education.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 53 (2012): Sozialethik für eine Gesellschaft des langen Lebens
sj-pdf-1-sgo-10.1177_2158244020975409 – Supplemental material for Assessment of ICT in Tertiary Education Applying Structural Equation Modeling and Rasch Model
Creators: name: A. Y. M. Atiquil Islam
name: Xiaoqing Gu
name: Crook, Charles
name: Spector, Jonathan Michael
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-sgo-10.1177_2158244020975409 for Assessment of ICT in Tertiary Education Applying Structural Equation Modeling and Rasch Model by A. Y. M. Atiquil Islam, Xiaoqing Gu, Charles Crook and Jonathan Michael Spector in SAGE Open
Arbeit – ein Schlüssel für soziale Gerechtigkeit!? Bericht zum 21. Forum Sozialethik (05.–07.09.2011) in der Katholischen Akademie Schwerte
Creators: name: Zink, Sebastian
name: Kirmse, Daniela
name: Wahl, Stefanie
name: Fisch, Andreas
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2012
Subjects: Arbeit; Gerechtigkeit; Gerechtigkeit, soziale

description: [Abstract fehlt]
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 53 (2012): Sozialethik für eine Gesellschaft des langen Lebens
E02453: Gregory of Tours, in his Glory of the Confessors (3), recounts how *Eusebius (bishop of Vercelli, ob. 371, S01219), from his grave in Vercelli (northern Italy) cures people and casts out demons, particularly on his feast day, when the possessed smash the lamps and are cured by the falling oil. Gregory's mother placed relics of Eusebius in the oratory of her house in Gaul, which saved her and the building from fire. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 3

Eusebius vero Vercellensis episcopus magnum huic Helario adiutorium contra hereses fuit, qui vivere se post tumulos praesentibus virtutibus manifestat. Nam in die natalis sui cum multi infirmi salventur, inergumini tomen rotatu valido per totam eclesiam debachantes et nimio confitentes torqueri cruciatu, elevati in aera, lignos, qui ad officium luminis succenduntur, manu verberantes effrangunt. De quo perfusi liquore, ilico, discedente daemone, personae purgantur, scitque tunc populus, tot infirmos esse mundatos, quot videret lignos effractos. Sed et omnia, quae sub ditione basilicae eius habentur ita pia protectione conservat, ne exinde quicquam auferatur ab aliquo. Nam videas inter hostes iniquos greges pecorum iumentorumque et ovium nec penitus a quoquam adtingi, cum vox sonuerit: 'Confessoris sunt haec Eusebi'.

'Bishop Eusebius of Vercelli was a great supporter of Hilary against heresies. He shows that he is still alive after his burial by his current miracles. For although many ill people are cured on his anniversary day, possessed by a demon people dance throughout the entire church in violent spins and believe that they are afflicted with powerful torments. They leap in the air and with their hands strike and break the lamps that are burning as lights. Once they are soaked with the oil from a lamp, immediately the demon leaves and the people are cleansed. Then the congregation knows that the number of ill people who have been healed matches the number of lamps that it sees are broken. The saint guards everything that his church owns with such a devout protection, lest someone steal something from it. For you might see that even among unjust enemies no one touches the herds of cattle, horses, and sheep when the voice has sounded: 'These belong to the confessor Eusebius.'

Gregory's mother places relics of Eusebius in the oratory of her house (Huius sancti reliquias mater mea in oratorio domus suae locavit). On one occasion, sparks from the fire jump to the rafters and threaten to burn down the house, but disaster is averted, which Gregory attributes to the proximity of the relics.

Text: Krusch 1969, 300-301. Translation: Van Dam 2004, 4-5.
sj-pdf-4-hol-10.1177_0959683620981689 – Supplemental material for The distribution of the guanaco (Lama guanicoe) in Patagonia during Late Pleistocene–Holocene and its importance for prehistoric human diet
Creators: name: Rindel, Diego D.
name: Moscardi, Bruno F.
name: S. Ivan Perez
Publisher: name: SAGE Journals
Year: 2020
Subjects: Geography
History

description: Supplemental material, sj-pdf-4-hol-10.1177_0959683620981689 for The distribution of the guanaco (Lama guanicoe) in Patagonia during Late Pleistocene–Holocene and its importance for prehistoric human diet by Diego D. Rindel, Bruno F. Moscardi and S. Ivan Perez in The Holocene
sj-pdf-1-eex-10.1177_2515127420979197 - Supplemental material for The Refill Shoppe: A Certified B Corp on the Quest for Growth to End Plastic Pollution
Creators: name: Ballesteros-Sola, Maria
name: Davidson, Loretta
name: Farrell, Edward
name: Hermida, Crystal
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-eex-10.1177_2515127420979197 for The Refill Shoppe: A Certified B Corp on the Quest for Growth to End Plastic Pollution by Maria Ballesteros-Sola, Loretta Davidson, Edward Farrell and Crystal Hermida in Entrepreneurship Education and Pedagogy
Supplemental Material, sj-pdf-1-ijq-10.1177_1609406920980954 - Exploring the Impact of Home-Schooling on the Psychological Wellbeing of Irish Families During the Novel Coronavirus (COVID-19) Pandemic: A Qualitative Study Protocol
Creators: name: O’Sullivan, Katriona
name: McGrane, Amy
name: Clark, Serena
name: Marshall, Kevin
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material, sj-pdf-1-ijq-10.1177_1609406920980954 for Exploring the Impact of Home-Schooling on the Psychological Wellbeing of Irish Families During the Novel Coronavirus (COVID-19) Pandemic: A Qualitative Study Protocol by Katriona O’Sullivan, Amy McGrane, Serena Clark and Kevin Marshall in International Journal of Qualitative Methods
sj-pdf-2-nnr-10.1177_1545968320981942 – Supplemental material for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial
Creators: name: Maijke Van Bloemendaal
name: Bus, Sicco A.
name: Nollet, Frans
name: Geurts, Alexander C. H.
name: Beelen, Anita
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, sj-pdf-2-nnr-10.1177_1545968320981942 for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial by Maijke van Bloemendaal, Sicco A. Bus, Frans Nollet, Alexander C. H. Geurts and Anita Beelen in Neurorehabilitation and Neural Repair
sj-pdf-4-nnr-10.1177_1545968320981942 – Supplemental material for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial
Creators: name: Maijke Van Bloemendaal
name: Bus, Sicco A.
name: Nollet, Frans
name: Geurts, Alexander C. H.
name: Beelen, Anita
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, sj-pdf-4-nnr-10.1177_1545968320981942 for Feasibility and Preliminary Efficacy of Gait Training Assisted by Multichannel Functional Electrical Stimulation in Early Stroke Rehabilitation: A Pilot Randomized Controlled Trial by Maijke van Bloemendaal, Sicco A. Bus, Frans Nollet, Alexander C. H. Geurts and Anita Beelen in Neurorehabilitation and Neural Repair
Heterometrus xanthopus
Creators: name: Kovařík, František
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpionidae
Heterometrus
Heterometrus xanthopus

description: Heterometrus xanthopus (Pocock, 1897)
(Fig. 32)
 Palamnaeus xanthopus Pocock, 1897: 116; Pocock, 1900: 92.
 Heterometrus xanthopus: Kraepelin, 1899: 115; Takashima, 1945: 93; Khatavkar & More, 1990: 79.
 Heterometrus (Chersonesometrus) xanthopus: Couzijn, 1981: 136; Tikader & Bastawade, 1983: 609; Kovařík, 1998: 137; Fet, 2000: 441; Bastawade, 2002: 296.
TYPE LOCALITY AND TYPE REPOSITORY. Kadas Tal, Satara, S. Dekhan; BMNH.
 TYPE MATERIAL EXAMINED. India, S. Dekhan, Bombay, Kadas Tal (Satara), 1♂ (lectotype hereby designated) 1♀ 2juvs. (paralectotypes), leg. A.D.Wilkins, BMNH No. 1896.9.26.88-981.
DIAGNOSIS. Adults 60–80 mm long. Color of adults uniformly reddish brown, legs and telson yellow to yellowish or reddish brown, always lighter colored than body. Pectinal teeth number 13–16 in both sexes. Male has longer femur and patella of pedipalp. Chela lobiform, in male narrower, its length to width ratio 2.1 in males and 1.6 in females. Entire manus covered by rounded minute granules that may merge but are devoid of carinae. Patella of pedipalp without pronouced internal tubercle. Carapace in juveniles with disc smooth, margins granulate and anterior portion tuberculate; in adults entire carapace sparsely granulated. Vesicle of telson as long as or longer than aculeus.
COMMENTS. Couzijn (1981: 136) stated that the type series consists of the holotype, allotype and three juveniles. However, he did not designate them, and they had not been designated by the original describer (Pocock, 1897: 116) either. Consequently, in order to stabilize the nomenclature of the species, I hereby designate one of the examined syntypes as the lectotype.
DISTRIBUTION. India: Maharashtra (Pocock, 1897: 116).
 Following is a key to the species of genus Heterometrus. Consult Tables 2-3 for a synopsis of the geographical distribution of these species.
description: Published as part of Kovařík, František, 2004, A review of the genus Heterometrus Ehrenberg, 1828, with descriptions of seven new species (Scorpiones, Scorpionidae), pp. 1-60 in Euscorpius 15 (15) on page 49, DOI: 10.18590/euscorpius.2004.vol2004.iss15.1, http://zenodo.org/record/12781607
sj-docx-1-nnr-10.1177_1545968320981960 – Supplemental material for Canadian Platform for Trials in Noninvasive Brain Stimulation (CanStim) Consensus Recommendations for Repetitive Transcranial Magnetic Stimulation in Upper Extremity Motor Stroke Rehabilitation Trials
Creators: name: Edwards, Jodi D.
name: Black, Sandra E.
name: Boe, Shaun
name: Boyd, Lara
name: Chaves, Arthur
name: Chen, Robert
name: Dukelow, Sean
name: Fung, Joyce
name: Kirton, Adam
name: Meltzer, Jed
name: Moussavi, Zahra
name: Neva, Jason
name: Paquette, Caroline
name: Ploughman, Michelle
name: Pooyania, Sepideh
name: Rajji, Tarek K.
name: Roig, Marc
name: Tremblay, Francois
name: Thiel, Alexander
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-nnr-10.1177_1545968320981960 for Canadian Platform for Trials in Noninvasive Brain Stimulation (CanStim) Consensus Recommendations for Repetitive Transcranial Magnetic Stimulation in Upper Extremity Motor Stroke Rehabilitation Trials by Jodi D. Edwards, Sandra E. Black, Shaun Boe, Lara Boyd, Arthur Chaves, Robert Chen, Sean Dukelow, Joyce Fung, Adam Kirton, Jed Meltzer, Zahra Moussavi, Jason Neva, Caroline Paquette, Michelle Ploughman, Sepideh Pooyania, Tarek K. Rajji, Marc Roig, Francois Tremblay and Alexander Thiel in Neurorehabilitation and Neural Repair
sj-pdf-1-eea-10.1177_0144598720985136 - Supplemental material for Pore structure and adsorption hysteresis of the middle Jurassic Xishanyao shale formation in the Southern Junggar Basin, northwest China
Creators: name: Liu, Bo
name: Gao, Yifei
name: Liu, Kouqi
name: Liu, Jinzhong
name: Ostadhassan, Mehdi
name: Wu, Tong
name: Li, Xianli
Publisher: name: SAGE Journals
Year: 2021
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-eea-10.1177_0144598720985136 for Pore structure and adsorption hysteresis of the middle Jurassic Xishanyao shale formation in the Southern Junggar Basin, northwest China by Bo Liu, Yifei Gao, Kouqi Liu, Jinzhong Liu, Mehdi Ostadhassan, Tong Wu and Xianli Li in Energy Exploration & Exploitation
Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach
Creators: name: Salamah, Maryana
name: Sipos, Bence
name: Schelz, Zsuzsanna
name: Zupkó, István
name: Kiricsi, Ágnes
name: Szalenkó-Tőkés, Ágnes
name: Rovó, László
name: Katona, Gábor
name: Balogh, György Tibor
name: Csóka, Ildikó
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The present study aimed to prepare and optimize lamotrigine-loaded bovine serum albumin nanoparticles (LAM-NP) using the Quality by Design (QbD) approach and to investigate both the in vitro and ex vivo effects of different cross-linking agents glutaraldehyde (GLUT), glucose (GLUC) and 1-(3-dimethylaminutesopropyl)-3-ethylcarbodiimide hydrochloride (EDC) on intranasal applicability. Cross-linked LAM-NP from EDC (NP-EDC-1) showed the lowest Z-average value (163.7 ± 1.9 nm) and drug encapsulation efficacy (EE%) of 97.31 ± 0.17%. The drug release of GLUC cross-linked LAM-NP (NP-GLUC-9), glutaraldehyde cross-linked LAM-NP (NP-GLUT-2), and NP-EDC-1 at blood circulation conditions was higher than the initial LAM. The results of the blood-brain barrier parallel artificial membrane permeability assay (BBB-PAMPA) showed an increase in the permeability of LAM through the BBB with NP-GLUC-9 and an increase in flux with all selected formulations. The ex vivo study showed that LAM diffusion from the selected formulations through the human nasal mucosa was higher than in case of initial LAM. The cytotoxicity study indicated that BSA-NP reduced LAM toxicity, and GLUC 9 mM and EDC 1 mg could be alternative cross-linking agents to avoid GLUT 2% v/v toxicity. Furthermore, permeability through Caco-2 cells showed that nasal epithelial transport/absorption of LAM was improved by using BSA-NPs. The use of BSA-NP may be a promising approach to enhance the solubility, permeability through BBB and decrease the frequency of dosing and adverse effects of LAM.
E02454: Gregory of Tours, in his Glory of the Confessors (4), recounts how *Martin (ascetic and bishop of Tours, ob. 397, S00050) prayed at the tomb of *Gatianus (first bishop of Tours, S01175) in Tours, and heard the voice of Gatianus asking Martin to bless him. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 4

Catianum enim episcopum ab Romanis episcopis ad urbem Turonicam transmissum primumque Turonicis pontificem datum fama ferente cognovimus. Ad cuius tumulum beatus Martinus, cum ad orationem venisset, post effusas preces, dicto etiam capitello, ait: 'Benedic', inquid, 'mihi, vir Dei'. Haec eo dicente, vox ad eum dilapsa auditur, dicens: 'Tu enim, deprecor, benedicas mihi, serve Domini'. Et data iterum oratione, diseessit. Admirabantur autem qui aderant eo tempore et dicebant, eum habitare tunc in Martinum, qui quondam Lazarum vocavit ex monumento.

'I have learned from current opinion that Gatianus was sent by Roman bishops to Tours and was entrusted as the first bishop of Tours. Once when the blessed Martin came to pray at his tomb, he poured out his requests, recited the verses [of psalms], and said: ‘Bless me, man of God.’ As he said this, a voice was heard descending to him. It said: ‘Servant of God, I request that you bless me.’ After Martin prayed again, he left. Those who were present at the time were surprised and said that he who had once summoned Lazarus from his tomb was now dwelling in Martin.'

Text: Krusch 1969, 301. Translation: Van Dam 2004, 5.
sj-pdf-1-jop-10.1177_0269881120981378 – Supplemental material for Cariprazine modulates sleep architecture in rats
Creators: name: Nyitrai, Gabriella
name: Kiss, Béla
name: Farkas, Bence
name: Balázs, Ottilia
name: Pálma Diószegi
name: Lendvai, Balázs
name: Czurkó, András
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-pdf-1-jop-10.1177_0269881120981378 for Cariprazine modulates sleep architecture in rats by Gabriella Nyitrai, Béla Kiss, Bence Farkas, Ottilia Balázs, Pálma Diószegi, Balázs Lendvai and András Czurkó in Journal of Psychopharmacology
title: Crack lung. An uncommon disease
Creators: name: González, Hugo
Publisher: name: EURORAD
Year: 2024
Subjects: subject: Chest imaging
subject: Emergency
subject: CT
subject: Clinical Case

description: Clinical History: A 49-year-old obese male with sleep apnoea, high smoking history, and occasional cocaine use presented with sudden chest pain, cough, and difficulty breathing. Tests revealed severe respiratory insufficiency, leukocytosis, and ground-glass opacities on computed tomography imaging.

description: 49 years, male
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility
Creators: name: Jurgelane, Inga
name: Egle, Karina
name: Grava, Andra
name: Galkina, Dana
name: Brante, Margarita
name: Melnichuks, Maksims
name: Skrinda-Melne, Marite
name: Salms, Girts
name: Dubnika, Arita
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Cannabidiol (CBD) is recognized for its therapeutic properties in various conditions. However, CBD’s limited water solubility and sensitivity to environmental stresses hinder its efficacy and bioavailability. Encapsulation in drug delivery systems, particularly liposomes, offers a promising solution. This study aims to prepare CBD-containing liposomes using commercially used lipids distearoyl phosphatidylcholine (DSPC) and dipalmitoyl phosphatidylcholine (DPPC), and 1,2 distearoyl-sn-glycero-3 phosphoethanolamine-N-[carbonyl-amino(polyethylene glycol)-4300] (ammonium salt) (DSPE-PEG) and to perform in vitro studies – cell viability and CBD release. Liposomes were synthesized using thin-film hydration method, and characterized by Fourier-transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), and scanning transmission electron microscopy (STEM). DLS analysis revealed that CBD incorporation reduced liposome size by 23–53%, depending on the liposomes. Encapsulation efficiency followed the order: DPPC CBD (63%) < DSPC CBD (74%) < DSPC DPPC CBD (81%) < DSPC DSPE-PEG CBD (87%). CBD release profiles indicated that DPPC CBD liposomes released the highest CBD amount initially, while DSPC DSPE-PEG CBD exhibited sustained release, achieving 79% release over 504 h. In vitro cell viability tests showed that blank liposomes were non-cytotoxic. However, CBD-loaded liposomes significantly reduced cell viability for defined type of CBD containing liposomes. The inclusion of DSPE-PEG improved encapsulation efficiency and liposome stability, making DSPC DSPE-PEG CBD liposomes more suitable for long-term CBD release. Compared to other studies, encapsulation of CBD in liposomes enhances its bioavailability, allowing lower concentrations of CBD to be directly delivered to cells, resulting in observable changes in cell viability.
E02456: Gregory of Tours, in his Glory of the Confessors (6), recounts how *Martin (ascetic and bishop of Tours, ob. 397, S00050) heals the sick at his tomb in Tours. Leo, a presbyter of Tours, moved a stone in Martin's basilica, on which the saint had sat (in order to clear a space for his own tomb), and was punished with death. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 6

Martin heals many sick people at his tomb in Tours; any doubters should visit Tours and see for themselves. Gregory writes that he has already written three books of the miracles of Martin, but wants to include a few here too. There followed this punishing miracle:

Extat nunc in ipsa superius memorata basilica, quam in eius honore fideles aedificaverunt, lapis, super quem vir beatus dicitur resedisse. Post multum autem tempus Leo quidam presbiter, ut sibi sepulchrum deponeret, lapidem sanctum a loco demovit; nec mora, ad domum suam cum tremore rediens, correptus a febre, die tertia expiravit, cognitumque est, offensum antestitem [ob praesumptionis auctoritatem]. Hoc igitur nostro tempore gestum recolimus.

'In the church mentioned above [the church of Martin in Tours] that the believers built in his honor there is still a stone on which the blessed man [Martin] is said to have sat. Many years later a presbyter named Leo moved the holy stone from its spot in order to set down his own tomb. Immediately he returned to his house with a tremor, was struck by a fever, and died on the third day. It was clear that bishop Martin had been insulted. I recall that this happened during my lifetime.'

Text: Krusch 1969, 302-303. Translation: Van Dam 2004, 8.
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis
Creators: name: Zhang, Meng
name: Zhang, Ru
name: Feng, Chunbo
name: Jiang, Xinnan
name: Xu, Xinchun
name: Wang, Jianxin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: The clinical treatment of rheumatoid arthritis (RA) with first-line therapeutic drugs is hindered by the poor solubility, low bioavailability, off-target toxicity, and insufficient accumulation in inflamed joints. Liposomes have been shown to mitigate some of these limitations in drug delivery systems. However, the use of cholesterol to stabilize liposomal structures remains controversial due to its potential association with cardiovascular diseases. Here, we developed a novel liposome based on ginsenoside compound K (CK), which not only serves as an effective therapeutic agent for RA but also replaces cholesterol as a membrane stabilizer to address these challenges. Compared with conventional liposomes, ginsenoside CK Liposomes (CK@Lipo) are excellent nanoparticles, with CK stabilizing the liposomal structure and providing targeting functionality toward inflamed joints. When encapsulated with dexamethasone (Dex), CK@Lipo exhibits a synergistic anti-inflammatory effect, slowing the progression of RA. This study provides a theoretical basis for the future development of multifunctional novel ginsenoside CK@Lipo.
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques
Creators: name: Story, Brett D.
name: Park, Sangwan
name: Roszak, Karolina
name: Shim, Jaeho
name: Motta, Monica
name: Ferneding, Michelle
name: Rudeen, Kayla M.
name: Blandino, Andrew
name: Ardon, Monica
name: Le, Sophie
name: Teixeira, Leandro B. C.
name: Yiu, Glenn
name: Mieler, William F.
name: Thomasy, Sara M.
name: Kang-Mieler, Jennifer J.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Space Science
Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: A clinical need exists for more effective intravitreal (IVT) drug delivery systems (DDS). This study tested the hypothesis that a novel biodegradable, injectable microsphere-hydrogel drug delivery system loaded with aflibercept (aflibercept-DDS) would exhibit long-term safety and biocompatibility in a non-human primate (NHP) model. We generated aflibercept-loaded poly (lactic-co-glycolic acid) microparticles with a modified double emulsion technique then embedded them into a biodegradable, thermo-responsive poly (ethylene glycol)-co-(L-lactic-acid) diacrylate/N-isopropylacrylamide hydrogel. Aflibercept-DDS (50 µL, 15 µg) was injected into the right eye of 23 healthy rhesus macaques. A complete ophthalmic examination, intraocular pressure (IOP), corneal pachymetry, specular microscopy, A-scan biometry, streak retinoscopy, spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and electroretinography (ERG) were performed monthly. Globes from 7 NHPs were histologically examined. Aflibercept-DDS was visualized in the vitreous up to 9 months post-IVT injection, slightly impeding fundoscopy in 4 of 23 eyes; no other consistent abnormalities were appreciated during ophthalmic examination. The IOP and total retinal thickness remained normal in all animals over all timepoints. Central corneal thickness, endothelial cell density, axial globe length, and refractive error did not significantly differ from baseline. Scotopic mixed rod-cone implicit times and amplitudes along with photopic cone response implicit times and amplitudes did not significantly differ from control values. No retinal or choroidal vascular abnormalities were detected with FA and normal retinal architecture was preserved using SD-OCT. Intravitreal injection of a biodegradable aflibercept-DDS was safe and well tolerated in NHPs up to 24 months.
Additional file 1 of Up-to-date quality survey and evaluation of neonatal screening programs in China
Creators: name: Zhang, Jinming
name: Jin, Lizi
name: Feng, Penghui
name: Fei, Yu
name: Li, Wen
name: Jiang, Ting
name: Zhang, Zehao
name: He, Falin
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1