cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Factors Associated With Medical Staff’s Engagement and Perception of a Quality Improvement Program for Acute Coronary Syndromes in Hospitals: A Nationally Representative Mixed-Methods Study in China
Creators: name: Smith, Jr., S.C
name: Guan, X
name: Huo, Y
name: Zhou, S
name: Ma, J
name: Dong, X
name: Zhang, Y
name: Li, N
name: Jin, Y
name: Zheng, Z.-J
name: Shi, H
name: Labresh, K.A
Publisher: name: American Heart Association Inc.
Year: 2022

description: BACKGROUND: Medical staff represent critical stakeholders in the process of implementing a quality improvement (QI) program. Few studies, however, have examined factors that influence medical staff engagement and perception regarding QI programs. METHODS AND RESULTS: We conducted a nationally representative survey of a QI program in 6 cities in China. Quantitative data were analyzed using multilevel mixed-effects linear regression models, and qualitative data were analyzed using the framework method. The engagement of medical staff was significantly related to knowledge scores regarding the specific content of chest pain center accreditation (β=0.42; 95% CI, 0.27–0.57). Higher scores for inner motivation (odds ratio [OR], 1.79; 95% CI, 1.18–2.72) and resource support (OR, 1.52; 95% CI, 1.02–2.24) and lower scores for implementation barriers (OR, 0.81; 95% CI, 0.67–0.98) were associated with improved treatment behaviors among medical staff. Resource support (OR, 4.52; 95% CI, 2.99–6.84) and lower complexity (OR, 0.81; 95% CI, 0.65–1.00) had positive effects on medical staff satisfaction, and respondents with improved treatment behaviors were more satisfied with the QI program. Similar findings were found for factors that influenced medical staff’s assessment of QI program sustainability. The qualitative analysis further confirmed and supplemented the findings of quantitative analysis. CONCLUSIONS: Clarifying and addressing factors associated with medical staff’s engagement and perception of QI programs will allow further improvements in quality of care for patients with acute coronary syndrome. These findings may also be applicable to other QI programs in China and other low-and middle-income countries. REGISTRATION: URL: https://www.chictr.org.cn/; Unique identifier: Chi-CTR2100043319.
Additional file 9 of Identification and characterization of transposable element AhMITE1 in the genomes of cultivated and two wild peanuts
Creators: name: Tang, Yanyan
name: Li, Xiaoting
name: Hu, Changli
name: Qiu, Xiaochen
name: Li, Jingjing
name: Li, Xin
name: Zhu, Hong
name: Wang, Jingshan
name: Sui, Jiongming
name: Qiao, Lixian
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9: Supplementary fig 9.
The Optical Gravitational Lensing Experiment. Cepheids in the Magellanic Clouds. IV. Catalog of Cepheids from the Large Magellanic Cloud
Creators: name: Udalski, A.
name: Soszynski, I.
name: Szymanski, M.
name: Kubiak, M.
name: Pietrzynski, G.
name: Wozniak, P.
name: Zebrun, K.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the Catalog of Cepheids from the LMC. The Catalog contains 1333 objects detected in the 4.5 square degree area of central parts of the LMC. About 3.4*10^5 BVI measurements of these stars were collected during the OGLE-II microlensing survey. The Catalog data include period, BVI photometry, astrometry, and R_21, ϕ_21 parameters of the Fourier decomposition of I-band light curve. The vast majority of objects from the Catalog are the classical Cepheids pulsating in the fundamental or first overtone mode. The remaining objects include Population II Cepheids and red giants with pulsation-like light curves. Tests of completeness performed in overlapping parts of adjacent fields indicate that completeness of the Catalog is very high: >96%. Statistics and distributions of basic parameters of Cepheids are also presented. Finally, we show the light curves of three eclipsing systems containing Cepheid detected among objects of the Catalog. All presented data, including individual BVI observations are available from the OGLE Internet archive.
description: 23 pages, Latex+psfig. Fig. 1 and Appendices (only one page) in JPG format. Acta Astronomica 49, 223. Full resolution Figure 1, all Appendices and the entire Catalog are available from the OGLE Internet archive: http://www.astrouw.edu.pl/~ftp/ogle or its US mirror http://www.astro.princeton.edu/~ogle Revised (journal) version, minor changes
title: Partial agenesis of the pericardium
Creators: name: Oliveira, Hélder
Publisher: name: EURORAD
Year: 2025
Subjects: subject: Cardiovascular
subject: Cardiac
subject: Mediastinum
subject: Peritoneum
subject: CT
subject: Education
subject: Normal variants
subject: Congenital
subject: Education and training
subject: Genetic defects
subject: Clinical Case

description: Clinical History: A 78-year-old man with no significant past medical history presented with a two-week history of a persistent, non-productive cough. A chest X-ray revealed a left-sided pleural effusion. There was no evidence of fever, weight loss or night sweats. A non-enhanced chest CT scan was performed to complete the study and clarify the findings.

description: 78 years, male
Large-Scale QSO-Galaxy Correlations and Weak Lensing
Creators: name: Williams, Liliya L. R.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Several recent studies show that bright, intermediate and high redshift optically and radio selected QSOs are positively correlated with nearby galaxies on a range of angular scales up to a degree. Obscuration by unevenly distributed Galactic dust can be ruled out as the cause, leaving weak statistical lensing as the physical process responsible. However the amplitude of correlations on < 1 degree scales is at least a factor of a few larger than lensing model predictions. A possible way to reconcile the observations and theory is to revise the weak lensing formalism. We extend the standard lensing formulation to include the next higher order term (second order) in the geodesic equation of motion for photons. We derive relevant equations applicable in the weak lensing regime, and discuss qualitative properties of the updated formulation. We then perform numerical integrations of the revised equation and study the effect of the extra term using two different types of cosmic mass density fluctuations. We find that nearby large-scale coherent structures increase the amplitude of the predicted lensing-induced correlations between QSOs and foreground galaxies by ~ 10% (not a factor of several required by observations), while the redshift of the optimal, i.e. `most correlated' structures is moved closer to the observer compared to what is predicted using the standard lensing equation.
description: extended Section 2; 20 pages, including 4 figures, accepted to ApJ
Serpula penicillus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Sabellida
Serpulidae
Serpula
Serpula penicillus

description: Serpula penicillus [spec. nov.]
S. testa teretiuscula recta basi flexuosa. �
Ellis corall. 92. t. 34.
Habitat in M. Mediterraneo ad Melitam.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 788, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Focus4TAPS pupil work collection - progression in plan-do-review
Creators: name: Earle, Sarah
Publisher: name: BathSPAdata
Year: 2025
Subjects: classificationCode: 390113
subject: Science, technology and engineering curriculum and pedagogy

description: A collection of primary school pupil work to exemplify different elements of the scientific enquiry plan-do-review cycle. This resource can be used as a source of ideas and as a stimulus for moderation discussions with colleagues to consider progression across school. Created to support the Focus4TAPS professional development programme, which arose from the Teacher Assessment in Primary Science (TAPS) project.
Minimal String Unification and Constraint on Hidden Sector
Creators: name: Kawabe, H.
name: Kobayashi, T.
name: Ohtsubo, N.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We examine whether a minimal string model possessing the same massless spectra as the MSSM can be obtained from $Z_4$, $Z_6$ and $Z_8$ orbifold constructions. Using an anomaly cancellation condition of the target space duality symmetry, we derive allowable values of a level $k_1$ of U(1)$_Y$ for the minimal string model on the orbifolds through computer analyses. We investigate threshold corrections of the gauge coupling constants of SU(3), SU(2) and U(1)$_Y$ and examine consistencies of the model with the LEP experiments. Further we investigate what kinds of hidden sectors are consistent with the minimal string models. Also their gauge coupling constants of the hidden groups are estimated. We discuss Yukawa couplings of the models.
description: 36 pages, KANAZAWA-94-09, Latex file
Felicia Hill-Briggs: A Tireless Worker for Better Outcomes and Social Justice in Diabetes
Creators: name: Fitzpatrick S.L
name: Kahn S.E
name: Buse J.B
name: Selvin E
name: Anderson C.A.M
Publisher: name: American Diabetes Association Inc.
Year: 2023

description: On 23 June 2023, our community lost Dr. Felicia Hill-Briggs, a remarkable colleague and friend to many. She was a professor, behavioral scientist, and social justice warrior. Beloved, admired, and respected, she left an extraordinary legacy of science and mentorship.
Non-GUT Baryogenesis and Large Scale Structure of the Universe
Creators: name: Kirilova, D. P.
name: Chizhov, M. V.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We discuss a mechanism for producing baryon density perturbations during inflationary stage and study the evolution of the baryon charge density distribution in the framework of the low temperature baryogenesis scenario. This mechanism may be important for the large scale structure formation of the Universe and particularly, may be essential for understanding the existence of a characteristic scale of 130h^{-1} Mpc (comoving size) in the distribution of the visible matter. The detailed analysis showed that both the observed very large scale of the visible matter distribution in the Universe and the observed baryon asymmetry value could naturally appear as a result of the evolution of a complex scalar field condensate, formed at the inflationary stage. Moreover, according to our model, the visible part of the Universe at present may consist of baryonic and antibaryonic regions, sufficiently separated, so that annihilation radiation is not observed.
description: 14 pages, 3 eps figures, final version for MNRAS
Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
Creators: name: Liu M
name: Baric R.S
name: Diamond M.S
name: Karl C.E
name: Alter G
name: Whitener B.M
name: McNamara R.P
name: Desai P
name: Chicz T.M
name: Edwards D.K
name: Mackin S.R
Publisher: name: Nature Research
Year: 2023

description: Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with antigenic changes in the spike protein are neutralized less efficiently by serum antibodies elicited by legacy vaccines against the ancestral Wuhan-1 virus. Nonetheless, these vaccines, including mRNA-1273 and BNT162b2, retained their ability to protect against severe disease and death, suggesting that other aspects of immunity control infection in the lung. Vaccine-elicited antibodies can bind Fc gamma receptors (FcγRs) and mediate effector functions against SARS-CoV-2 variants, and this property correlates with improved clinical coronavirus disease 2019 outcome. However, a causal relationship between Fc effector functions and vaccine-mediated protection against infection has not been established. Here, using passive and active immunization approaches in wild-type and FcγR-knockout mice, we determined the requirement for Fc effector functions to control SARS-CoV-2 infection. The antiviral activity of passively transferred immune serum was lost against multiple SARS-CoV-2 strains in mice lacking expression of activating FcγRs, especially murine FcγR III (CD16), or depleted of alveolar macrophages. After immunization with the pre-clinical mRNA-1273 vaccine, control of Omicron BA.5 infection in the respiratory tract also was lost in mice lacking FcγR III. Our passive and active immunization studies in mice suggest that Fc–FcγR engagement and alveolar macrophages are required for vaccine-induced antibody-mediated protection against infection by antigenically changed SARS-CoV-2 variants, including Omicron strains.
Standard Model Predictions for Weak Boson Pair Production in E-E- Scattering
Creators: name: Cuypers, Frank
name: Kolodziej, Karol
name: Rueckl, Reinhold
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study polarized $e^-e^-$ scattering into $\WW$, $\WZ$ and $\ZZ$ final states within the framework of the standard model of electroweak interactions. These mechanisms for producing pairs of weak gauge bosons are potential backgrounds to new reactions beyond the realm of the standard model. At a centre-of-mass energy of 500 GeV the total cross sections are calculated to be 2.5, 9.4 and 1.0 fb, respectively, for unpolarized beams. The energy behaviour of the cross sections as well as particularly interesting differential distributions are presented and the topology of the final states is discussed.
description: 19 pages, 8 figures (not included), PostScript version available via anonymous ftp from hep.physik.uni-muenchen.de in preprints/mpi9427.ps, Munich preprint MPI-PhT/94-27
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Creators: name: Zhang, L
name: Tang, W
name: Huang, L
name: McCabe, E
name: Liu, X
name: Yu, Z
name: Hu, M
name: Zhou, J
name: Chen, S
name: Liu, R
name: Choi, C.H.J
name: Duan, L
name: Cheng, A.S.-L
name: Wu, H
name: Wang, Y
name: Liu, H
name: Sung, J.J.-Y
Publisher: name: Cell Press
Year: 2023

description: The local microenvironment where tumors develop can shape cancer progression and therapeutic outcome. Emerging evidence demonstrate that the efficacy of immune-checkpoint blockade (ICB) is undermined by fibrotic tumor microenvironment (TME). The majority of hepatocellular carcinoma (HCC) develops in liver fibrosis, in which the stromal and immune components may form a barricade against immunotherapy. Here, we report that nanodelivery of a programmed death-ligand 1 (PD-L1) trap gene exerts superior efficacy in treating fibrosis-associated HCC when compared with the conventional monoclonal antibody (mAb). In two fibrosis-associated HCC models induced by carbon tetrachloride and a high-fat, high-carbohydrate diet, the PD-L1 trap induced significantly larger tumor regression than mAb with no evidence of toxicity. Mechanistic studies revealed that PD-L1 trap, but not mAb, consistently reduced the M2 macrophage proportion in the fibrotic liver microenvironment and promoted cytotoxic interferon gamma (IFNγ)+tumor necrosis factor α (TNF-α)+CD8+T cell infiltration to the tumor. Moreover, PD-L1 trap treatment was associated with decreased tumor-infiltrating polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) accumulation, resulting in an inflamed TME with a high cytotoxic CD8+T cell/PMN-MDSC ratio conductive to anti-tumor immune response. Single-cell RNA sequencing analysis of two clinical cohorts demonstrated preferential PD-L1 expression in M2 macrophages in the fibrotic liver, thus supporting the translational potential of nano-PD-L1 trap for fibrotic HCC treatment.
Serpula ringens Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Sabellida
Serpulidae
Serpula
Serpula ringens

description: Serpula ringens [spec. nov.]
S. testa tereti recta punctato-arenacea. Fig. 8.
Baker. micr. t. 8. f. 2, 3, 4, 5.
Schaeff. monogr. 1755.
Habitat in Europae Lacubus frequens; minuta.
Testa Dentalii structura, sed basi tenuiore fixa, ex arenulis confectis constructa, minima oculo armato dignoscenda. Animalculum refert florem didynamiae.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 788, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Dust Formation and Inhomogeneous Mass Loss from AGB Stars
Creators: name: Soker, Noam
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We examine the flow from asymptotic giant branch (AGB) stars when along a small solid angle the optical depth due to dust is very large. We consider two types of flows. In the first, small cool spots are formed on the surface of slowly rotating AGB stars. During the last AGB phase when mass loss rate is high, the dust shields the region above it from the stellar radiation. This leads to both further dust formation in the shaded region, and the convergence of the stream toward the shaded region. A concentration of magnetic cool spots toward the equator will lead to a density contrast of up to a few between the equatorial and polar directions. This process can explain the positive correlation between high mass loss rate and a larger departure from sphericity in progenitors of elliptical planetary nebulae. In the second type of flow, the high density in the equatorial plane is formed by a binary interaction, where the secondary star is close to, but outside the AGB envelope. The shielding of the radiation by dust results in a very slow and dense flow in the equatorial plane. We suggest this flow as an alternative explanation for the equatorial dense matter found at several hundred astronomical units around several post-AGB binary systems.
description: 15 pages + 2 figures (postscript), to be published in MNRAS
Four Cases of Cholesterol Management Informed by the 2018 American Heart Association/American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol
Creators: name: Chuzi, S
name: Stone, N.J
name: Lloyd-Jones, D.M
name: Virani, S.S
name: Pfenniger, A
name: Grundy, S.M
name: Smith, Jr., S.C
name: Blumenthal, R.S
Publisher: name: American Medical Association
Year: 2019

description: These 4 hypothetical cases highlight some of the new features in the 2018 American Heart Association/American College of Cardiology multisociety cholesterol management guidelines. Topics include management issues in a secondary prevention patient judged to be at very high risk of another event, a patient with familial hypercholesterolemia with a low-density lipoprotein cholesterol level of 190 mg/dL or greater (to convert to millimoles per liter, multiply by 0.0259), a primary prevention patient with intermediate (7.5%-19.9%) 10-year atherosclerotic cardiovascular risk, and a patient who has statin-associated adverse effects. A multiple-choice format is used to engage clinicians in selecting the best choice based on guidance from the new 2018 cholesterol management guidelines.
Limits on the Gunn-Peterson Effect at z = 5
Creators: name: Songaila, Antoinette
name: Hu, Esther M.
name: Cowie, Lennox L.
name: McMahon, Richard G.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report new limits on the Gunn-Peterson effect at a redshift near 5 using spectroscopic observations of the z = 5 Sloan Digital Sky Survey quasar, J033829.31+002156.3, made with the LRIS and HIRES spectrographs on the Keck telescopes. Lower resolution spectrophotometrically calibrated observations made with LRIS over the wavelength region 4500-9600 angstroms were used to obtain a continuum shape and to flux calibrate much higher resolution (R = 36,000) observations made with HIRES. The LRIS data show an Oke D_A index of 0.75. Portions of the HIRES spectrum return to near the extrapolated continuum level. Including both statistical and systematic errors we place an upper limit of tau = 0.1 on the regions of minimum opacity. We argue that, even if this opacity arises in underdense regions of the intergalactic gas, we require a high value of the metagalactic ionizing flux at these redshifts ($J_ν \gg 4 \times 10^{-23}~{\rm ergs cm^{-2} s^{-1} Hz^{-1} sr^{-1}}$ at $z\sim4.72$) to produce a solution which is consistent with even minimum nucleosynthesis estimates of the baryon density. We also report the presence of a Mg II absorption system of extremely high equivalent width ($W_{λ,rest}(2796)=1.73$ Å) at z=2.304.
description: 15 pages including 2 figures. Also available at http://www.ifa.hawaii.edu/~acowie/gp_5.html To be published in Astrophysical Journal Letters
John Arthur Joseph Pateman - Bibliography from John Arthur Joseph Pateman. 18 May 1926 — 18 May 2011
Creators: name: Scazzocchio, Claudio
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: John Pateman was a distinguished British microbial geneticist. He came from a working-class area of London and a non-academic background. His earliest contribution to genetics was the discovery (together with John Fincham) of intracistronic complementation, an important phenomenon to understand the relationship of genetic information and protein structure; this at a time when the actual coding relationships of DNA and proteins were not yet worked out. Later on, he and his students made a fundamental contribution to the understanding of control of gene expression in eukaryotic microorganisms, providing some of the earliest examples of positive control. This work also led to the discovery of a new enzyme cofactor, the only one discovered through purely genetic evidence. He worked at various universities in Britain and Australia and trained a number of students who further developed the subject.
Formulation of two lipid-based membrane–core nanoparticles for FOLFOX combination therapy
Creators: name: Huang, L
name: Guo, J
Publisher: name: Springer Nature
Year: 2022

description: FOLFOX is a combination of folinic acid (FnA), 5-fluorouracil (5-Fu) and oxaliplatin (OxP). It has been used as the standard treatment for colorectal cancer (CRC) and hepatocellular carcinoma (HCC). This treatment is effective, but its high toxicity is dose limiting, and the drugs need to be taken for a long time. To lower the toxicity so that higher doses can be administered with minimal side effects, two lipid-based membrane–core (MC) nanoformulations, Nano-Folox and Nano-FdUMP, have recently been developed by using the nanoprecipitation technique. The combination of Nano-Folox (containing platinum drug and FnA) and Nano-FdUMP (containing fluorine drug) significantly improves the antitumor effect against CRC and HCC relative to FOLFOX (the combination of free drugs), resulting in long-term survival of animals without significant toxic signs. Here, we describe two formulation protocols. First, for Nano-Folox, a Pt(DACH)•FnA nanoprecipitate is formed by [Pt(DACH)(H2O)2]2+ (the active form of OxP) and FnA2−, and the resultant nanoprecipitate is encapsulated inside the lipid nanoparticles (NPs) modified with the PEGylated aminoethyl anisamide (AEAA, a targeting ligand for sigma-1 receptor overexpressing on CRC and HCC). Second, for Nano-FdUMP, FdUMP (the active metabolite of 5-Fu) is entrapped inside the amorphous Ca3(PO4)2 nanoprecipitate, and the resultant Ca3(PO4)2•FdUMP nanoprecipitate is encapsulated into the AEAA-targeted PEGylated lipid NPs. The procedures for Nano-Folox and Nano-FdUMP take ~17 h and ~4 h, respectively (~17 h if they are prepared simultaneously). Procedures for the physicochemical (~30 h) and cytotoxic (~54 h) characterization are also described.
FigShare1_Genitalia_Bristle_Number
Creators: name: Nagy, Olga
name: Courtier-Orgogozo, Virginie
Publisher: name: figshare
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Genitalia Bristle Number Figure for 'Correlated Evolution of two Copulatory Organs via a Single Cis-Regulatory Nucleotide Change'
Running genetic algorithms on Hadoop for solving high dimensional optimization problems
Creators: name: Yildirim, Güngör
name: Hallac, İbrahim R
name: Aydin, Galip
name: Tatar, Yetkin
Publisher: name: arXiv
Year: 2018
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Hadoop is a popular MapReduce framework for developing parallel applications in distributed environments. Several advantages of MapReduce such as programming ease and ability to use commodity hardware make the applicability of soft computing methods for parallel and distributed systems easier than before. In this paper, we present the results of an experimental study on running soft computing algorithms using Hadoop. This study shows how a simple genetic algorithm running on Hadoop can be used to produce solutions for high dimensional optimization problems. In addition, a simple but effective technique, which did not need MapReduce chains, has been proposed.
wragge/ndf2018: A GLAM data workbench for reluctant researchers
Creators: name: Sherratt, Tim
Publisher: name: Zenodo
Year: 2019
Subjects: GLAM Workbench
DigitalNZ
digital collections

description: We all know that our GLAM collections hold important data for research in the humanities. An increasing number of institutions are opening up collection data for public use through APIs or downloads. But how do we help non-technical users understand the possibilities of large scale collection data? How do we create pathways that lead them through the code to the questions they want to ask? In my latest attempt to introduce researchers to the wonders of collection data, I've created an GLAM workbench that uses Jupyter notebooks to combine live code with worked examples and tutorials. With minimal setup, and a few presses of Shift+Enter, anyone can harvest bulk data from Trove, or analyse series from the National Archives of Australia -- all within their browser. The workbench is an experiment in itself, as I learn more about the technology and explore different approaches. But I think it offers some exciting possibilities.
FOXA1 overexpression suppresses interferon signaling and immune response in cancer
Creators: name: Weinshilboum, R
name: Zhang, X
name: Yan, Y
name: Wei, T
name: Hollern, D.P
name: Boughey, J.C
name: Wang, L
name: Tang, X
name: Ma, J
name: Wang, L
name: Xie, H
name: Weroha, S.J
name: Ye, D
name: Huang, H
name: Wen, S
name: He, Y
name: Sheng, H
name: Bryce, A.H
name: Ren, S
name: Xiao, Y.-T
name: Kalari, K.R
name: Goetz, M.P
name: Suman, V.J
name: Perou, C.M
name: Hou, X
name: Dong, H
name: Carter, J.M
name: Pan, Y
name: Su, H
Publisher: name: American Society for Clinical Investigation
Year: 2021

description: Androgen receptor–positive prostate cancer (PCa) and estrogen receptor–positive luminal breast cancer (BCa) are generally less responsive to immunotherapy compared with certain tumor types such as melanoma. However, the underlying mechanisms are not fully elucidated. In this study, we found that FOXA1 overexpression inversely correlated with interferon (IFN) signature and antigen presentation gene expression in PCa and BCa patients. FOXA1 bound the STAT2 DNA-binding domain and suppressed STAT2 DNA-binding activity, IFN signaling gene expression, and cancer immune response independently of the transactivation activity of FOXA1 and its mutations detected in PCa and BCa. Increased FOXA1 expression promoted cancer immuno- and chemotherapy resistance in mice and PCa and BCa patients. These findings were also validated in bladder cancer expressing high levels of FOXA1. FOXA1 overexpression could be a prognostic factor to predict therapy resistance and a viable target to sensitize luminal PCa, BCa, and bladder cancer to immuno- and chemotherapy.
Framing of national HPV vaccine recommendations and willingness to recommend at ages 9-10
Creators: name: Queen T.L
name: Brewer N.T
name: Reiter P.L
name: Kahn B.Z
name: Kritikos K.I
name: Gilkey M.B
Publisher: name: Taylor and Francis Ltd.
Year: 2023

description: Proactive HPV vaccination at age 9 better prevents infection and improves vaccine series completion. Because national organizations recommend starting the vaccine at different ages, we sought to understand the impact of these recommendation frames. In 2022, we surveyed 2,527 US clinical staff (45% physicians) who provide HPV vaccine for children. We randomized respondents to one of three frames based on HPV vaccine recommendations of national organizations or a no-recommendation control, and assessed willingness to recommend HPV vaccine for children ages 9–10. Respondents also reported perceived benefits of HPV vaccination at ages 9 or 12. Recommending HPV vaccination “at ages 11–12” led to lower willingness to vaccinate at ages 9–10 than control (37% vs. 54%, p <.05). Recommending vaccination “at ages 9–12” led to similar willingness as control. However, “starting at age 9” led to higher willingness than control (63% vs. 54%, p <.05). Results were similar across respondents’ training, specialty, or years in practice, or their clinic’s rurality or healthcare system membership. More common benefits of recommending at age 9 than 12 were avoiding the topic of sex (24% vs. 10%, OR = 2.78, 95%CI: 2.23, 3.48) and completing the vaccine series before age 13 (56% vs. 47%, OR = 1.44, 95%CI: 1.23, 1.68). Less common benefits for age 9 were having parents ready to talk about HPV vaccine and agreeing to vaccination (both p <.05). An effective way to encourage proactive HPV vaccination is to say that it starts at age 9. Aligning national recommendations to start at age 9 can promote timely vaccination.
Gravitational Coupling and the Cosmological Constant
Creators: name: Bisabr, Yousef
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We deal with a dynamical mechanism in which a large cosmological constant, as suggested by inflationary scenarios, decays due to expansion of the universe. This mechanism has its origin in the gravitational coupling of the vacuum density. We assume that the vacuum couples anomalously to gravity that is the metric tensor that appears the gravitational part is not the same as that appears the matter part as suggested by weak equivalence principle. Instead, the two metric tensors are taken to be conformally related. We show that this provides a dynamical mechanism which works during expansion of the universe. We also consider some observational consequences of such a gravitational model.
description: 7 pages, no figure. To appear in IJMPD
Fully human antibody v H domains to generate mono and bispecific CAR to target solid tumors
Creators: name: McGuinness B
name: Shou P
name: Du H
name: Zhou X
name: Li H
name: Dukhovlinova E
name: Johnston C
name: Fucà G
name: Dotti G
name: Wang G
Publisher: name: BMJ Publishing Group
Year: 2021

description: Background Chimeric antigen receptor (CAR) T cells are effective in B-cell malignancies. However, heterogeneous antigen expression and antigen loss remain important limitations of targeted immunotherapy in solid tumors. Therefore, targeting multiple tumor-associated antigens simultaneously is expected to improve the outcome of CAR-T cell therapies. Due to the instability of single-chain variable fragments, it remains challenging to develop the simultaneous targeting of multiple antigens using traditional single-chain fragment variable (scFv)-based CARs. Methods We used Humabody V H domains derived from a transgenic mouse to obtain fully human prostate-specific membrane antigen (PSMA) V H and mesothelin (MSLN) V H sequences and redirect T cell with V H based-CAR. The antitumor activity and mode of action of PSMA V H and MSLN V H were evaluated in vitro and in vivo compared with the traditional scFv-based CARs. Results Human V H domain-based CAR targeting PSMA and MSLN are stable and functional both in vitro and in vivo. V H modules in the bispecific format are capable of binding their specific target with similar affinity as their monovalent counterparts. Bispecific CARs generated by joining two human antibody V H domains can prevent tumor escape in tumor with heterogeneous antigen expression. Conclusions Fully human antibody V H domains can be used to generate functional CAR molecules, and redirected T cells elicit antitumoral responses in solid tumors at least as well as conventional scFv-based CARs. In addition, V H domains can be used to generate bispecific CAR-T cells to simultaneously target two different antigens expressed by tumor cells, and therefore, achieve better tumor control in solid tumors.
Lithophyta Linnaeus, 1758, ord. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Lithophyta

description: Lithophyta [ord. nov.]
IV. LITHOPHYTA.
Animalia Mollusca composita, pullulantia e Corallio Lapideo subjecto, cui inserta, quodque aedificant.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 789, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Infrared emission from interstellar dust cloud with two embedded sources: IRAS 19181+1349
Creators: name: Karnik, A. D.
name: Ghosh, S. K.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Mid and far infrared maps of many Galactic star forming regions show multiple peaks in close proximity, implying more than one embedded energy sources. With the aim of understanding such interstellar clouds better, the present study models the case of two embedded sources. A radiative transfer scheme has been developed to deal with an uniform density dust cloud in a cylindrical geometry, which includes isotropic scattering in addition to the emission and absorption processes. This scheme has been applied to the Galactic star forming region associated with IRAS 19181+1349, which shows observational evidence for two embedded energy sources. Two independent modelling approaches have been adopted, viz., to fit the observed spectral energy distribution (SED) best; or to fit the various radial profiles best, as a function of wavelength. Both the models imply remarkably similar physical parameters.
description: 17 pages, 6 Figures, uses epsf.sty. To appear in Journal of Astronophysics & Astronomy
Vanilla mexicana Mill.
Creators: name: Damián-Parizaca, Alexander
name: Karremans, Adam P.
name: Mitidieri-Rivera-Rivera, Nicole
name: Cameron, Kenneth M.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Vanilla
Vanilla mexicana

description: 16.Vanilla mexicanaMill. (Miller 1768: without number)
Epidendrum vanilla L. (Linnaeus 1753: 952)
Vanilla aromatica Sw. (Swartz 1799: 66), nom. superfl. illeg.
Vanilla anaromatica Griseb. (Grisebach 1864: 638), nom. superfl. illeg.
Vanilla epidendrum Mirb. (Mirbel 1802: 249), nom. superfl. illeg.
Type.
Lectotype (designated by Reveal (2009: 359) as lectotype of V. mexicana and by Cribb in Cafferty and Jarvis (1999: 47) as lectotype of E. vanilla): HAITI • “ Volubilis siliquosa mexicana plantagini folio ” in Catesby, Natural History of Carolina, Florida and the Bahama Islands vol. 2 (Catesby 1747: appendix 7, pl. 7, reproduced in Karremans et al. 2020: fig. 25 A).
Notes.
Upon proposing Vanilla mexicana, Miller cited a single illustration by Catesby (1747: fig. 4). This was later proven to be based on unpublished illustrations by Plumier (see Karremans et al. 2020: fig. 25). Miller attributed his species to an aromatic entity, noting that “ … with this fruit the Spaniards perfume their chocolate, ” effectively combining the non-aromatic species illustrated by Plumier (Karremans et al. 2020: fig. 25 C – D) with the species of the Mexicas, valued for their fragrant fruits. Miller’s slip resulted in the typification of Vanilla mexicana (Reveal 2009) with the illustration of a species that is neither aromatic nor native to Mexico.
Under Epidendrum vanilla, Linnaeus listed the following elements: Epidendrum foliis ovato-oblongis nervosis, sessilibus caulinis, cirrhis spiralibus (van Royen 1740: 13, Linnaeus 1749: 13); Vanilla piperis arbori jamaicensis innascens (Plukenet 1696: 381); Vanille (Merian 1705: 25); Volubilis siliquosa, plantaginis folio (Catesby 1747: 7); Lobus aromaticus subfuscus terebinthi corniculis simili (Bauhin 1671: 404). Additional materials are indirectly listed by citation of a reference that contains it. For example, both Royen’s Florae Leydensis and Linnaeus’s Acta Universitatis Upsaliensis refer to Vanilla flore viridi & albo, fructu nigrescente of Plumier, which is not directly cited here. From this is becomes clear that Linnaeus believed these elements belonged to a single taxon, the Vanilla of commerce. Today we know that the materials in this list represent different, often unrelated, Vanilla species, belonging to both aromatic and non-aromatic taxa (Karremans and Pupulin 2023).
description: Published as part of Damián-Parizaca, Alexander, Karremans, Adam P., Mitidieri-Rivera-Rivera, Nicole & Cameron, Kenneth M., 2025, Towards a monograph of membranaceous Vanillas: a nomenclatural revision of Vanilla subgen. Vanilla (Vanilloideae, Orchidaceae), pp. 111-121 in Plant Ecology and Evolution 158 (1) on pages 111-121, DOI: 10.5091/plecevo.140667
New representation of two-loop propagator and vertex functions
Creators: name: Czarnecki, Andrzej
name: Kilian, Ulrich
name: Kreimer, Dirk
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a new method of calculating scalar propagator and vertex functions in the two-loop approximation, for arbitrary masses of particles. It is based on a double integral representation, suitable for numerical evaluation. Real and imaginary parts of the diagrams are calculated separately, so that there is no need to use complex arithmetics in the numerical program.
description: 13 pages (9 figures not included; complete ps file available from the authors), LaTeX, MZ-TH/94-13
Effective two-dimensional model for granular matter with phase separation
Creators: name: Risso, Dino
name: Soto, Rodrigo
name: Guzman, Marcelo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Granular systems confined in vertically vibrated shallow horizontal boxes (quasi two-dimensional geometry) present a liquid to solid phase transition when the frequency of the periodic forcing is increased. An effective model, where grains move and collide in two-dimensions is presented, which reproduces the aforementioned phase transition. The key element is that besides the two-dimensional degrees of freedom, each grain has an additional variable $ε$ that accounts for the kinetic energy stored in the vertical motion in the real quasi two-dimensional motion. This energy grows monotonically during free flight, mimicking the energy gain by collisions with the vibrating walls and, at collisions, this energy is instantaneously transferred to the horizontal degrees of freedom. As a result, the average values of $ε$ and the kinetic temperature are decreasing functions of the local density, giving rise to an effective pressure that can present van der Waals loops. A kinetic theory approach predicts the conditions that must satisfy the energy grow function to obtain the phase separation, which are verified with molecular dynamics simulations. Notably, the effective equation of state and the critical points computed considering the velocity--time-of-flight correlations differ only slightly from those obtained by simple kinetic theory calculations that neglect those correlations.
Finite Temperature Reduction of the SU(2) Higgs-Model with Complete Static Background
Creators: name: Jakovác, A.
name: Patkós, A.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Direct evaluation of the 1-loop fluctuation determinant of non-static degrees of freedom in a complete static background is advocated to be more efficient for the determination of the effective three-dimensional model of the electroweak phase transition than the one-by-one evaluation of Feynman diagrams. The relation of the couplings and fields of the effective model to those of the four-dimensional finite temperature system is determined in the general 't Hooft gauge with full implementation of renormalisation effects. Only field renormalisation constants display dependence on the gauge fixing parameter. Characteristics of the electroweak transition are computed from the effective theory in Lorentz-gauge. The dependence of various physical observables on the three-dimensional gauge fixing parameter is investigated.
description: 12 pages (LATEX) + 1 table (TEX) appended
Cell cycle and differentiation of Sca-1+ and Sca-1− hematopoietic stem and progenitor cells
Creators: name: Páral, Petr
name: Kateřina Faltusová
name: Molík, Martin
name: Renešová, Nicol
name: Luděk Šefc
name: Nečas, Emanuel
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Hematopoietic stem and progenitor cells (HSPCs) are crucial for lifelong blood cell production. We analyzed the cell cycle and cell production rate in HSPCs in murine hematopoiesis. The labeling of DNA-synthesizing cells by two thymidine analogues, optimized for in-vivo use, enabled determination of the cell cycle flow rate into G2-phase, the duration of S-phase and the average cell cycle time in Sca-1+ and Sca-1− HSPCs. Determination of cells with 2n DNA content labeled in preceding S-phase was then used to establish the cell flow rates in G1-phase. Our measurements revealed a significant difference in how Sca-1+ and Sca-1− myeloid progenitors self-renew and differentiate. Division of the Sca-1+ progenitors led to loss of the Sca-1 marker in about half of newly produced cells, corresponding to asymmetric cell division. Sca-1− cells arising from cell division entered a new round of the cell cycle, corresponding to symmetric self-renewing cell division. The novel data also enabled the estimation of the cell production rates in Sca-1+ and in three subtypes of Sca-1− HSPCs and revealed Sca-1 negative cells as the major amplification stage in the blood cell development.
RAISING ENGLISH SPEAKING PROFICIENCY TO B2
Creators: name: Kaipbergenova, Khurliman
Publisher: name: Zenodo
Year: 2024

description: Prior to starting the process of raising  English proficiency to B2, it's critical to comprehend exactly what it means. B2 is an intermediate level of English proficiency that is defined by the ability to speak with confidence and effectiveness in the majority of daily settings. At this level, one should be able to grasp a broad variety of written and spoken English, articulate thoughts and ideas, and understand and engage in conversations on themes of familiarity. You must educate yourself with the necessary abilities and competences in order to raise your English proficiency to B2. For instance, should be able to participate in debates on a range of subjects and comprehend the essential concepts of lengthy texts. Additionally, you should be able to create materials like essays and reports that are clear and precise. Moreover, should be proficient in vocabulary and grammar and be able to comprehend and speak spoken English at a respectable level of fluency.
Vanilla organensis Rolfe
Creators: name: Damián-Parizaca, Alexander
name: Karremans, Adam P.
name: Mitidieri-Rivera-Rivera, Nicole
name: Cameron, Kenneth M.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Vanilla
Vanilla organensis

description: 17.Vanilla organensisRolfe (Rolfe 1896: 452)
Fig. 2 G
Type.
BRAZIL • Organ Mountains; Gardner 632; lectotype (designated by Soto-Arenas 2010: 385; plant with inflorescence on the bottom left side of the sheet, excluding the detached flower): K! [K 000463758]; isolectotypes: AMES! [AMES 00090735], G! [G 00618049], GH! [GH 00090735], K! [K 000463757, K 000463758], NY! [NY 00803972], US! [US 00093332], W! [W 0254006]; tracing W! [W 0254002]; remaining syntypes: Glaziou 14320, K! [K 000940254], P! [P 00367022]; Glaziou 11620, K! [K 000940255], P! [P 00367023]; Miers s. n., K! [K 000940253].
Notes.
When proposing Vanilla organensis, Rolfe listed four different collections, considered syntypes. Gardner 632 at the Lindley Herbarium (K) was selected by Soto-Arenas and Cribb (2010) as the lectotype, and four additional specimens were designated as isolectotypes. The sheet on which Gardner 632 (K) is conserved includes two other elements that do not belong to the same collection, a stem with inflorescence on the top right and a detached flower, which are excluded.
description: Published as part of Damián-Parizaca, Alexander, Karremans, Adam P., Mitidieri-Rivera-Rivera, Nicole & Cameron, Kenneth M., 2025, Towards a monograph of membranaceous Vanillas: a nomenclatural revision of Vanilla subgen. Vanilla (Vanilloideae, Orchidaceae), pp. 111-121 in Plant Ecology and Evolution 158 (1) on pages 111-121, DOI: 10.5091/plecevo.140667
The interplay of phonon and exciton-mediated superconductivity in hybrid semiconductor-superconductor structures
Creators: name: Skopelitis, Petros
name: Cherotchenko, Evgenia D.
name: Kavokin, Alexey V.
name: Posazhennikova, Anna
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We predict a strong enhancement of the critical temperature in a conventional Bardeen-Cooper-Schrieffer (BCS) superconductor in the presence of a bosonic condensate of exciton-polaritons. The effect depends strongly on the ratio of the cutoff frequencies for phonon and exciton-polariton mediated BCS superconductivity, respectively. We also discuss a possible design of hybrid semiconductor-superconductor structures suitable for the experimental observation of such an effect.
description: 5 pages, 3 figures, accepted in Phys. Rev. Lett
Radiative Leptonic Decays of Heavy Mesons
Creators: name: Burdman, G.
name: Goldman, T.
name: Wyler, D.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We compute the photon spectrum and the rate for the decays $B(D)\to lν_lγ$ These photonic modes constitute a potentially large background for the purely leptonic decays which are used to extract the heavy meson decay constants. While the rate for $D\to l\n\g$ is small, the radiative decay in the $B$ meson case could be of comparable magnitude or even larger than $B\to\m\n$. This would affect the determination of $f_B$ if the $τ$ channel cannot be identified. We obtain theoretical estimates for the photonic rates and disscuss their possible experimental implications.
description: 12 pages, RevTex, 3 uuencoded figures included