cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone
Creators: name: Schmid, R.
name: Lai, C.
name: Weber, J.
name: Ghashghaei, H. T.
name: Pevny, L.
name: Lloyd, K. C. K.
name: Anton, E. S.
name: Eisenstat, D. D.
name: Schwab, M. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Coordinated regulation of neuronal progenitor differentiation in the subventricular zone (SVZ) is a fundamental feature of adult neurogenesis. However, the molecular control of this process remains mostly undeciphered. Here, we investigate the role of neuregulins (NRGs) in this process and show that a NRG receptor, ErbB4, is primarily expressed by polysialylated neural cell adhesion molecule immature neuroblasts but is also detected in a subset of GFAP+ astroglial cells, ependymal cells, and Dlx2+ precursors in the SVZ. Of the NRG ligands, both NRG1 and -2 are expressed by immature polysialylated neural cell adhesion molecule neuroblasts in the SVZ. NRG2 is also expressed by some of the GFAP+ putative stem cells lining the ventricles. Infusion of exogenous NRG1 leads to rapid aggregation of Dlx2+ cells in the SVZ and affects the initiation and maintenance of organized neuroblast migration from the SVZ toward the olfactory bulb. In contrast, the infusion of NRG2 increased the number of Sox2 and GFAP+ precursors in the SVZ. An outcome of this NRG2 effect is an increase in the number of newly generated migrating neuroblasts in the rostral migratory stream and GABAergic interneurons in the olfactory bulb. The analysis of conditional null mice that lack NRG receptor, ErbB4, in the nervous system revealed that the observed activities of NRG2 require ErbB4 activation. These results indicate that different NRG ligands affect distinct populations of differentiating neural precursors in the neurogenic regions of the mature forebrain. Furthermore, these studies identify NRG2 as a factor capable of promoting SVZ proliferation, leading to the formation of new neurons in vivo.
Formación en TIC, estrategia para transformar las prácticas pedagógicas de los estudiantes del II semestre del programa de Formación Complementaria de Educadores en la Escuela Normal Superior “Claudina Múnera” de Aguadas, Caldas.
Creators: name: Rios Torres, Ester Johane
Publisher: name: Universidad de Cartagena
Year: 2023
Subjects: subject: Plataforma virtual
subject: Docentes - Entrenamiento en servicio
subject: Pedagogía - Enseñanza

description: Este proyecto tiene como objeto una propuesta formativa al programa de Formación Complementaria de Educadores, preparando a las docentes cabalmente para el desarrollo correcto y completo de sus enseñanzas. Para el cumplimiento de los objetivos, se implementó un Modelo de Investigación Acción Pedagógica, el cual reevaluó la labor docente, y posteriormente se aplicó una propuesta de formación en los estudiantes, involucrando el uso de las TICs. A su vez, un enfoque cualitativo se desarrolló, pretendiendo la sustentación de procesos hermenéuticos en los cuales se describe el objeto de estudio de forma clara, comprendiéndolo y explicándolo pertinentemente. Al finalizar el proceso, se evidenció la necesidad que se hallaba en la Escuela Primaria ante el uso correcto de las TICs; a su vez, la propuesta permitió una mayor motivación por parte de los maestros para la planeación de los procesos curriculares, y de los estudiantes al recibir las enseñanzas. La mayor persuasión observada fue la mejoría en los subcampos del conocimiento, la cual permitió la profundización educativa por medio de las competencias TIC. Como conclusión, se experimentó el fortalecimiento por parte de las estrategias de los docentes, la motivación estudiantil y, por tanto, la el fortalecimiento del aprendizaje.
Lidar-based Gust Load Alleviation - Results Obtained on a Generic Long Range Aircraft Configuration
Creators: name:  CHRISTIAN WALLACE
name:   NICOLAS FEZANS
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: GUST LOAD ALLEVIATION
LIDAR
PREVIEW CONTROL

description: In this paper a lidar-based preview gust load alleviation controller is synthesised via modem robust control methods in discrete time and optimised for an industrial long-range aircraft configuration. The synthesis and load analysis is performed using a set of 54 linear-time-invariant state-space models corresponding to a wide range of mass distributions and flight conditions. The controller performance is tested in a realistic hybrid and multi-rate simulation environment in which, in addition to the aeroelastic aircraft model (continuous time) and the various control functions in discrete time, the lidar measurement chain (sensor, wind estimation) as well as speed and position-limited actuators are simulated. The load alleviation performance is evaluated for a wide range of mass distributions, altitudes, airspeeds and gust lengths, leading to results based on over 4000 analysed gust load cases. The paper concludes with a discussion of the impact of the GLA control function on the structural loads, the load hierarchy and the general aircraft behaviour. The gust load alleviation controller achieves a reduction in peak bending moment between 17 % and 18 % at the important wing root, about 20 % in the middle of the wing and still over 10 % near the wing tip. It barely reaches the rate and position limits even on the extreme gusts defined in the certification specifications for large aeroplanes and only moderate increases of peak gust loads are observed on other load types or stations. Directly outside of the engine position a few percent increase in torsional moment is found. The controller yields an increase of about 50 % of the HTP gust loads, which is not critical as the HTP is usually, by far, not sized by gust loads but rather by manoeuvre loads. If needed, this figure could drastically be reduced by reducing the aggressiveness of the pitching behaviour and tolerating slight higher loads on the wing.
Bimodal activity of diurnal flower visitation at high elevation
Creators: name: Xu, Xin
name: Ren, Zong-Xin
name: Trunschke, Judith
name: Kuppler, Jonas
name: Zhao, Yan-Hui
name: Knop, Eva
name: Wang, Hong
Publisher: name: Zenodo
Year: 2023

description: Successful pollination in animal-pollinated plants depends on the temporal overlap between flower presentation and pollinator foraging activity. Variation in the temporal dimension of plant-pollinator networks has been investigated intensely across flowering seasons. However, over the course of a day, the dynamics of plant-pollinator interactions may vary strongly due environmental fluctuations. It is usually assumed there is a unimodal, diurnal, activity pattern, while alternative multi-modal types of activity patterns are often neglected and deserve greater investigation. Here, we quantified the daily activity pattern of flower visitors in two different habitats contrasting high elevation meadows versus forests in Southwest China to investigate the role of abiotic conditions in the temporal dynamics of plant-pollinator interactions. We examined diurnal activity patterns for the entire pollinator community. Pollinator groups may differ in their ability to adapt to habitats and abiotic conditions, which might be displayed in their patterns of activity. We hypothesized, that 1) pollinator communities show multi-modal activity patterns, 2) patterns differ between pollinator groups and habitat types, and 3) abiotic conditions explain observed activity patterns. In total, we collected 4988 flower visitors belonging to six functional groups. There was a bimodal activity pattern when looking at the entire pollinator community, and in five out of six flower visitor groups (exempting solitary bees). Bumblebees, honeybees, dipterans, lepidopterans, and other insects showed activity peaks in the morning and afternoon, whereas solitary bees were most active at midday. Activity of all six pollinator groups increased as solar radiation increased and then decreased after reaching a certain threshold. Our findings suggest that in habitats at higher elevations, a bimodal activity pattern of flower visitation is commonly employed across most pollinator groups that are diurnal foragers. This pattern may be caused by insects avoiding overheating due to elevated temperatures when exposed to high solar radiation at midday.
description: Funding provided by: Strategic Priority Research Program of the Chinese Academy of Sciences*
Crossref Funder Registry ID:
Award Number: XDB31000000Funding provided by: National Natural Science Foundation of China
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001809
Award Number: 32071670Funding provided by: National Natural Science Foundation of China
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100001809
Award Number: 31700361Funding provided by: Natural Science Foundation of Yunnan Province
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100005273
Award Number: 2019FB035Funding provided by: Yunlin Scholarship of Yunnan Province*
Crossref Funder Registry ID:
Award Number: YLXL20170001
Detection of a QPO in 5 XMM-Newton observations of RE J1034+396
Creators: name: Alston, W. N.
name: Markevičiūtė, J.
name: Kara, E.
name: Fabian, A. C.
name: Middleton, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The X-ray quasi-periodic oscillation (QPO) at $\sim 2.6 \times 10^{-4}$ Hz in RE J1034+396 has been robustly observed in the 0.2-10 keV band of one $\sim 90$ ks XMM-Newton observation, but was not detected in subsequent observations. Here, we investigate the power spectral density (PSD) of 8 archival XMM-Newton observations of RE J1034+396, and search for the presence of QPOs in three energy bands: soft (0.3-0.8 keV); hard (1.0-4.0 keV) and total (0.2-10.0 keV). We find a significant detection of a QPO feature in the hard-band PSD of 5 low flux/spectrally-harder observations. The QPO frequency has remained persistent at $\sim 2.6 \times 10^{-4}$ Hz over $\sim 4$ years of observations, though it is no longer detected in the soft band, except in the original observation. This result increases the duration where the QPO is present by a factor of three (now $\sim 250$ ks), allowing for a better understanding of the QPO phenomenon observed in both Active Galactic Nuclei (AGN) and black hole X-ray binaries (BHBs).
description: 6 pages, 3 figures. Accepted for publication in MNRAS Letters
Desarrollo de una secuencia didáctica en la plataforma Moodle para potenciar el pensamiento numérico en estudiantes de séptimo grado de la Institución Educativa Yatí en el municipio de Magangué.
Creators: name: Fernández Arrieta, Fernando
Publisher: name: Universidad de Cartagena
Year: 2023
Subjects: subject: Herramientas tecnológicas
subject: Matemática - Aprendizaje
subject: Moodle (Programa para Computador)

description: Este proyecto tiene como objeto evidenciar cómo, a través de la implementación de una secuencia didáctica digital, se logró promover y fortalecer el desarrollo del pensamiento numérico en un grupo de estudiantes. Estos estudiantes presentaban bajos resultados en las diversas actividades relacionadas con las matemáticas, debido a la ausencia de estrategias metodológicas que incorporaran el uso de recursos educativos digitales innovadoras. Esta estrategia permitió fortalecer habilidades como el reconocimiento de números enteros en diferentes contextos y la realización de sumas y restas con este conjunto numérico, competencias fundamentales para abordar y resolver problemas planteados. En resumen, los hallazgos de este proyecto respaldan la idea de que la incorporación de una secuencia didáctica digital, apoyada en la plataforma Moodle, tiene un impacto positivo en el desarrollo del pensamiento numérico de los estudiantes, al fomentar la adquisición de habilidades esenciales para la resolución de problemas matemáticos.
Outflow measurements on porous injector elements
Creators: name:  MARKUS SELZER
name:   JONAS PEICHL
name:   IVENS DANIEL HOFFMANN
name:   DMITRY SUSLOV
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: POROUS MEDIA
INJECTOR
OUTFLOW DISTRIBUTION

description: In this report, the outflow distribution on a porous injector element is measured on the pore level using dynamic pressure measurements. The results are used to link features in the outflow distribution to the characteristics of the specific porous material. Furthermore, the flow direction of the individual outflow jets is investigated and finally the evolution of the flow field downstream of the injector element is analysed. The results provide further understanding of the flow field created by the porous injector element, hinting also at possible optimizations of this technology.
The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA
Creators: name: Lad, C.
name: Schroeder, G. K.
name: Wolfenden, R.
name: Williams, N. H.
name: Wyman, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Phosphodiester linkages, including those that join the nucleotides of DNA, are highly resistant to spontaneous hydrolysis. The rate of water attack at the phosphorus atom of phosphodiesters is known only as an upper limit, based on the hydrolysis of the dimethyl phosphate anion. That reaction was found to proceed at least 99% by C–O cleavage, at a rate suggesting an upper limit of 10−15 s−1 for P–O cleavage of phosphodiester anions at 25°C. To evaluate the rate enhancement produced by P–O cleaving phosphodiesterases such as staphylococcal nuclease, we decided to establish the actual value of the rate constant for P–O cleavage of a simple phosphodiester anion. In dineopentyl phosphate, C–O cleavage is sterically precluded so that hydrolysis occurs only by P–O cleavage. Measurements at elevated temperatures indicate that the dineopentyl phosphate anion undergoes hydrolysis in water with a t1/2 of 30,000,000 years at 25°C, furnishing an indication of the resistance of the internucleotide linkages of DNA to water attack at phosphorus. These results imply that staphylococcal nuclease (kcat = 95 s−1) enhances the rate of phosphodiester hydrolysis by a factor of ≈1017. In alkaline solution, thymidylyl-3′-5′-thymidine (TpT) has been reported to decompose 105-fold more rapidly than does dineopentyl phosphate. We find however that TpT and thymidine decompose at similar rates and with similar activation parameters, to a similar set of products, at pH 7 and in 1 M KOH. We infer that the decomposition of TpT is initiated by the breakdown of thymidine, not by phosphodiester hydrolysis.
Construction Materials COS11P1
Creators: name: Nleya, Faith
name: Ngxongo, Bathandwa
Publisher: name: Walter Sisulu University
Year: 2022
Subjects: Civil engineering not elsewhere classified
Construction materials

description: Subject : Construction Materials Subject code : COS11P1 Qualification : National Diploma Engineering: Civil Examiners : Mrs. Faith Nleya and Mr. NB Ngxongo Moderator : Mr R Kieck Date : July 2019
Aula virtual “Matemáticas Vagas” para fortalecer el planteamiento y resolución de problemas matemáticos, en grados octavos de la Institución Educativa Sagrado Corazón.
Creators: name: Vanegas Piñeros, Alvaro
Publisher: name: Universidad de Cartagena
Year: 2023
Subjects: subject: Herramientas tecnológicas
subject: Matemática - Aprendizaje
subject: Matemáticas - Enseñanza con ayuda de computadores

description: Este proyecto tiene como objeto analizar el efecto de la estrategia tic “aulas vagas” en el fortalecimiento de competencias de planteamiento y resolución de problemas matemáticos, de los estudiantes de grado octavo de la Institución educativa, con una metodología de tipo descriptivo, puesto que pretende estudiar las actividades realizadas por los estudiantes, de manera que la investigación está delimitada bajo un enfoque cualitativo, teniendo en cuenta que se efectuó un diagnóstico del estado actual de las competencias de planteamiento y resolución de problemas matemáticos de una muestra de estudiantes de octavo grado, logrando con ello el diseño de actividades estratégicas en el aula virtual "Matemáticas VAGAS" que motiven a los estudiantes a utilizar correctamente las herramientas de enseñanza digital en sus procesos de aprendizaje, donde la implementación del aula virtual "Matemáticas VAGAS” para promover PA G E 47 actitudes positivas de los estudiantes de grado octavo, terminando con la evaluación del efecto de la implementación de “aulas vagas” a través del desarrollo de un post test en los estudiantes de octavo grado de la IESC.
The up-regulation of ferritin expression using a small-molecule ligand to the native mRNA
Creators: name: Fox, P. M.
name: Thorp, H. H.
name: Ropp, P. A.
name: Tibodeau, J. D.
name: Theil, E. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The binding of small molecules to distinctive three-dimensional structures in mRNA provides a new dimension in RNA control, previously limited to the targeting of secondary structures with antisense and RNA interference; such targeting can modulate mRNA function and rates of protein biosynthesis. Small molecules that selectively bind the iron-responsive element (IRE), a specific three-dimensional structure in the noncoding region of the ferritin mRNA model that is recognized by the iron-regulatory protein repressor, were identified by using chemical footprinting. The assay used involved an oxoruthenium(IV) complex that oxidizes guanine bases in RNA sequences. Small molecules that blocked oxidation of guanines in the internal loop region were expected to selectively increase the rate of ferritin synthesis, because the internal loop region of the ferritin IRE is distinctive from those of other IREs. The natural product yohimbine was found (based on gel mobility shifts) to block cleavage of the internal loop RNA site by >50% and seemed to inhibit protein binding. In the presence of yohimbine, the rate of biosynthesis of ferritin in a cell-free expression system (rabbit reticulocyte lysate) increased by 40%. Assignment of the IRE–yohimbine interaction as the origin of this effect was supported by a similar increase in synthesis of luciferase protein in a chimera of the IRE and luciferase gene. The identification of a small, drug-like molecule that recognizes a naturally occurring three-dimensional mRNA structure and regulates protein biosynthesis rates raises the possibility that small molecules can regulate protein biosynthesis by selectively binding to mRNA.
Multi-epoch VLBA observations of radio galaxy 0932+075: is this a compact symmetric object?
Creators: name: Marecki, A.
name: Sokołowska, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A part of the radio structure of the galaxy 0932+075 emerged as a possible compact symmetric object (CSO) after the observation with the Very Long Baseline Array (VLBA) at 5 GHz in 1997. More than a decade later, we carried out observations at 5, 15.4, and 22.2 GHz using the VLBA to test this possibility. We report here that we have found a component whose spectrum is inverted in the whole range from 5 GHz to 22 GHz and we label it a high-frequency peaker (HFP). Using a set of 5 GHz images from two epochs separated by 11.8 years and a set of 15.4 GHz images separated by 8.2 years, we were able to examine the proper motions of the three components of the CSO candidate with respect to the HFP. We found that their displacements cannot be reconciled with the CSO paradigm. This has led to the rejection of the hypothesis that the western part of the arcsecond-scale radio structure of 0932+075 is a CSO anchored at the HFP. Consequently, the HFP cannot be labelled a core and its role in this system is unclear.
description: 7 pages, accepted for publication in A&A
Mathematics I MAT10P1; MATH1P1; MATM1P0; MTM11P
Creators: name: Mbebe, Monalisa
name: Stofile, Pateka
Publisher: name: Walter Sisulu University
Year: 2022
Subjects: Civil engineering not elsewhere classified

description: Subject : Mathematics I Subject code : MAT10P1; MATH1P1; MATM1P0; MTM11P Qualification : National Diploma Engineering: Civil Examiners : Ms. MM Mbebe and Ms. P Stofile Moderator : Mr M Mofoka Date : June 2019
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
Creators: name: Warren, M. R.
name: Majumder, S.
name: Earp, H. S.
name: Mohler, J. L.
name: Parker, C. E.
name: Whang, Y. E.
name: Mahajan, N. P.
name: Liu, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Activation of the androgen receptor (AR) may play a role in androgen-independent progression of prostate cancer. Multiple mechanisms of AR activation, including stimulation by tyrosine kinases, have been postulated. We and others have recently shown involvement of activated Cdc42-associated tyrosine kinase Ack1 in advanced human prostate cancer. Here we provide the molecular basis for interplay between Ack1 and AR in prostate cancer cells. Activated Ack1 promoted androgen-independent growth of LNCaP and LAPC-4 prostate xenograft tumors, AR recruitment to the androgen-responsive enhancer, and androgen-inducible gene expression in the absence of androgen. Heregulin-stimulated HER2 activation induced Ack1 activation and AR tyrosine phosphorylation. Ack1 knockdown inhibited heregulin-dependent AR tyrosine phosphorylation, AR reporter activity, androgen-stimulated gene expression, and AR recruitment. Ack1 was recruited to the androgen-responsive enhancers after androgen and heregulin stimulation. In 8 of 18 primary androgen-independent prostate tumor samples, tyrosine-phosphorylated AR protein was detected and correlated with the detection of tyrosine-phosphorylated Ack1. Neither was elevated in androgen-dependent tumors or benign prostate samples. Activated Ack1 phosphorylated AR protein at Tyr-267 and Tyr-363, both located within the transactivation domain. Mutation of Tyr-267 completely abrogated and mutation of Tyr-363 reduced Ack1-induced AR reporter activation and recruitment of AR to the androgen-responsive enhancer. Expression of AR point mutants inhibited Ack1-driven xenograft tumor growth. Thus, Ack1 activated by surface signals or oncogenic mechanisms may directly enhance AR transcriptional function and promote androgen-independent progression of prostate cancer. Targeting the Ack1 kinase may be a potential therapeutic strategy in prostate cancer.
Optimal control of a combat aircraft with thrust vectoring during take off
Creators: name:  JUAN MANZANERO
name:   DIEGO LODARES
name:   MIGUEL SABARIS BOULLOSA
name:   FRANCISCO ASENSIO NIETO
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: FLIGHT CONTROL LAWS
OPTIMAL CONTROL
THRUST VECTORING

description: In this work we explore the benefits of thrust vectoring to reduce the take-off distance of a combat aircraft. To assess the aircraft\'s pure performance and handling qualities, the optimal control method is proposed herein to avoid the need to design preliminary Flight Control Laws (FCL) to simulate the aircraft. This becomes even more relevant for combat aircraft, usually open-loop longitudinally unstable, where a suboptimal FCL might not fully exploit the capabilities of the plant and lead to misleading design decisions. We conclude that without thrust vectoring, the aircraft is limited by its capability to rotate early on and build up enough angle of attack, whereas with thrust vectoring it is limited by the maximum rotation angle due to tail strikes. Overall, we find that the take-off distance is reduced by 38%. The optimal control method helps to understand how thrust vectoring can be used efficiently, to introduce a pitch up moment that induces the rotation, followed by a pitch down moment that stops it and prevents impacts against the tarmac.
An Estimation of Production Coupling Effects of Direct Payments for Rice Farms
Creators: name: Lee, Moonho
name: Lee, Moonho
Publisher: name: Unknown
Year: 2020
Subjects: subject: Crop Production/Industries
subject: direct payments for rice
subject: coupling
subject: expected utility maximization model

description: This study provides empirical estimation results concerning the degree of production coupling for the fixed and variable direct payment program designed for stabilizing rice farmers’ income. Based on a set of producer’s expectation formulations, we analyzed the impacts of direct payments on the rice cultivation area, using a panel data estimation technique. To consider the risk preference of farmers, we used an expected utility maximization model under the expected utility hypothesis. Also, we explicitly included a variable capturing truncated variance of rice price related to variable direct payments. Our estimation results indicate that both fixed and variable direct payments tend to have production coupling effects. Specifically, we found that the production coupling effect of variable direct payments was higher than that of fixed direct payments. We also discovered that the rice cultivation area has been affected by these direct payments via the insurance effects (variable direct payments) and wealth effects (fixed direct payments).
Diseño de un entorno virtual de aprendizaje de Ciencias Naturales utilizando el aprendizaje basado en problemas y saberes sobre anime en estudiantes Otaku del grado séptimo del Instituto Olga Santa María.
Creators: name: Ramírez Cortes, Lina Johanna
Publisher: name: Universidad de Cartagena
Year: 2023
Subjects: subject: Herramientas virtuales
subject: Ciencias naturales - Enseñanza
subject: Caricatura - Enseñanza

description: Este proyecto tiene como objeto facilitar los procesos de enseñanza aprendizaje de las ciencias naturales en el grado séptimo del Instituto técnico Olga Santamaría.Los Otaku, cultura juvenil emergente de la era digital, poseen saberes relacionados con el anime que pueden ser el punto de partida desde el cual enriquecer algunas prácticas educativas.Los resultados más relevantes de esta investigación están relacionados con la identificación de algunos elementos importantes que aportan a la comprensión de los jóvenes en esta cultura juvenil en la etapa escolar. Se concluye que el anime es una herramienta que facilita los procesos de enseñanza aprendizaje de las ciencias naturales. Para ello; es importante la transposición didáctica por parte del docente que permita transformar los saberes de los estudiantes fans de anime en contenido educativo de calidad.
"La Cabreta" (Spain): an outdoor goat and sheep production linked to forest and grasslands
Creators: name: Biosca, Joan Alibés
Publisher: name: Zenodo
Year: 2016
Subjects: Agroforestry
Goat
Sheep
Forest grazing
Agrosilvopastoral

description: "La Cabreta" is an outdoor goat and sheep production enterprise linked to forest and grasslands. It was established in 2008 in Meira (Lugo province of Galicia region) on rented lands from the Banco de Terras de Galicia. The starting point for “La Cabreta” was 26 ha of abandoned land full of bushes (Ulex europaeus and Ulex gallii). In order to control and take advantage of the bushes, they introduced a 150 goat flock and transformed 10 ha to grassland with a long term mixture of seeds. Thanks to the cooperation with their neighbors, they found a way to help forest owners by grazing during the summertime the bushes that grow under the trees (bramble), while grazing dairy cow grasslands during the autumn and winter, when grass from spring grass silage areas is available. With this system the forest owners get understory bushes removed, while grassland areas are better used. So, the whole system is optimized.
Shaping the trees
Creators: name: van Lerberghe, Philippe
Publisher: name: Zenodo
Year: 2017
Subjects: Pruning

description: Trees planted at wide spacing naturally develop a shorter trunk, with a greater tendency to a sinuous and forked shape. They often bear many vigorous lateral branches that can hamper the movement of agricultural machinery.

A wide array of factors can lead to defects in shape (high wind, frost, drought, snow, presence of birds and insects, game, changes in soil fertility) or more structural (genetics and quality of seedlings). All defects in shape should be corrected as soon as they appear.

Early, moderate and gradual pruning interventions are necessary to increase the rigor of the trees, straightness of the trunk and produce quality marketable timber. Those interventions have to be undertaken at the right time and with the adequate material.
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
Creators: name: Smithies, O.
name: Kim, H.-S.
name: Caron, K.
name: Hagaman, J.
name: Nishikimi, T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Adrenomedullin (AM) is a potent vasodilator peptide in plasma at picomolar levels. Polymorphisms in the human AM gene have been associated with genetic predisposition to diabetic nephropathy and proteinuria with essential hypertension, and numerous studies have demonstrated that endogenous AM plays a role in protecting the heart and kidneys from fibrosis resulting from cardiovascular disease. Elevated plasma levels of AM are associated with pregnancy and sepsis and with cardiovascular stress and hypertension. However, there are no reports of the effects of genetic differences in the expression of the endogenous AM gene and of gender on blood pressure in these circumstances or on the pathological changes accompanying hypertension. To address these questions, we have generated mice having genetically controlled levels of AM mRNA ranging from ≈50% to ≈140% of wild-type levels. These modest changes in AM gene expression have no effect on basal blood pressure. Although pregnancy and sepsis increase plasma AM levels, genetically reducing AM production does not affect the transient hypotension that occurs during normal pregnancy or that is induced by treatment with lipopolysaccharide. Nor does the reduction of AM affect chronic hypertension caused by a renin transgene. However, 50% normal expression of AM enhances cardiac hypertrophy and renal damage in male, but not female, mice with a renin transgene. These observations suggest that the effect of gender on the role of AM in counteracting cardiovascular damage in humans merits careful evaluation.
User’s Guide to Central Alaskan Yup’ik Stress Derivation
Creators: Alden, McKinley
Arnhold, Anja
Publisher: name: University of Alberta Library
Year: 2022

This document is a step-by-step description of the process for deriving stress in Central Alaskan Yup'ik words, complete with a brief overview of the stress system of the language and detailed examples.
Agostic interactions in transition metal compounds
Creators: name: Brookhart, M.
name: Parkin, G.
name: Green, M. L. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The impact of agostic interactions (i.e., 3-center–2-electron MHC bonds) on the structures and reactivity of organotransition metal compounds is reviewed.
GHS-POP2G - Population to Grid
Creators: name: Schiavina, Marcello
name: Freire, Sergio
name: MacManus, Kytt
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: GHSL
Landsat 8
Land cover
Population Density
Urban
Earth Observations Toolkit for Sustainable Cities and Human Settlements

description: What it is for? 
The Population To Grid (GHS-POP2G) is a flexible tool to produce geospatial population grids in GeoTIFF format from vector census data (polygons or points).
The tool operationalises the workflow developed for the production of the Global Human Settlement Layer Population Grid layers (GHS-POP).
The principal purpose of the tool is the production of the population grid used as input for the Degree of Urbanisation Grid (GHS-DUG) also produced in the GHSL framework.
It is part of the  GHS Layers  which are extensively used in in crisis management, as they are key variable in disaster alert system. GHSL area used also for disaster response as population density, provide insights on the population in need of emergency relief. Increasingly GHS layers are used to projecting future climate change impact by combining population projections with that of hazard impacts.
Urban planners use GHS layers to understand the built-environment within a city, and regional planners use GHS layers to assess the impact of the expansion of cities on other land covers. The layers also inform policy makers that assess the degree of urbanization in the respective countries, or urbanization trends across countries or across regions of interest. The spatial arrangement of built up and green areas within a city is used to quantify climate impact, quality of life in cities based on the amount of green area or the access to transport facilities.
Related materials
This resource is associated with the Earth Observations Toolkit for Sustainable Cities and Human Settlements. If you want to learn more about it, please, check the EO Toolkit portal (https://eotoolkit.unhabitat.org/), a place where you will find use cases, learning material, and many other tools and resources related to the Sustainable Development Goal 11 and New Urban Agenda.
Taking the Scribe Seriously
Creators: name: Burghardt, Bettina
Publisher: name: Corpus Masoreticum Working Papers
Year: 2022

description: MS Vat ebr. 14 was produced by Eliyya ha-Naqdan, a scribe from northern France who lived in the 13th century. All direct information we have about him today is contained in the colophons of this manuscript and of MS Berlin or. quart. 9, the only two manuscripts of his still extant today. In both cases, Eliyya provides a date of completion, but the information given in Vat ebr. 14 presents difficulties that have let previous investigators to believe that he must have made a mistake. In this paper, we systematically evaluate every plausible option for reading Vat ebr. 14’s main colophon to examine the possibility of identifying a date of completion for which the data given by Eliyya match up. We show that an internally consistent date exists, Tuesday, Av 16, 4999 (July 19, 1239 C.E.), only five days before the date the majority of scholars who assume that Eliyya did make a mistake arrive at, Sunday, Av 21, 4999 (July 24, 1239 C.E.). We thus conclude that the assumption that the scribe made an error is unwarranted, and that Tuesday, Av 16, 4999 (July 19, 1239 C.E.) is the likely date of the manuscript’s completion.
description: Corpus Masoreticum Working Papers, Nr. 1 (2022)
Estrategia didáctica apoyada en la herramienta digital Genially para el proceso de enseñanza y aprendizaje de los sistemas y sentidos del cuerpo humano en los estudiantes del grado tercero de la Institución Educativa Juan Jacobo Rousseau de Arauquita.
Creators: name: Luna Cáceres, Nancy Mayerly
Publisher: name: Universidad de Cartagena
Year: 2023
Subjects: subject: Herramientas tecnológicas
subject: Anatomía humana - Enseñanza
subject: Ciencias naturales - Enseñanza

description: Este proyecto tiene como objeto fortalecer el proceso de enseñanza de los sistemas y sentidos del cuerpo humano, en los estudiantes del grado tercero de la Institución Educativa Juan Jacobo Rousseau de Arauquita, esta estrategia se desarrolló de forma secuencial en alineación con cuatro fases guiadas por cada uno de los objetivos propuesto. El impacto pedagógico en el proceso de enseñanza y aprendizaje se evidencia en la mejora de los contenidos y las calificaciones durante el desarrollo de las competencias, los cuales fueron basadas en las características y necesidades de los estudiantes, el impacto tecnológico se refleja en la implementación y el uso de las TIC y sus herramientas en contextos que la institución aún no ha incursionado.
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
Creators: name: Anver, M.
name: Dickins, R.
name: DePinho, R. A.
name: Bennett, D. C.
name: Merlino, G.
name: Ichikawa, T.
name: Sharpless, N. E.
name: Sviderskaya, E. V.
name: Ha, L.
name: Lowe, S.
name: Krimpenfort, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we show that genetic deficiency in Arf but not p53 facilitates rapid development of melanoma in a genetically engineered mouse model. This difference is accounted for, at least in part, by the unanticipated observation that, unlike fibroblasts, senescence control in melanocytes is strongly regulated by Arf and not p53. Moreover, oncogenic NRAS collaborates with deficiency in Arf, but not p53, to fully transform melanocytes. Our data demonstrate that ARF and p53, although linked in a common pathway, suppress tumorigenesis through distinct, lineage-dependent mechanisms and suggest that ARF helps restrict melanoma progression by executing the oncogene-induced senescence program in benign nevi. Thus, therapeutics designed to restore wild-type p53 function may be insufficient to counter melanoma and other malignancies in which ARF holds p53-independent tumor suppressor activity.
Invisible fencing in wood pasture
Creators: name: Burgess, Paul
name: Chinery, Francesca
name: Eriksson, George
name: Pershagen, Erica
name: Pérez-Casenave, Cristina
name: Giannitsopoulos, Michail
Publisher: name: Zenodo
Year: 2017
Subjects: Invisible fencing
GPS
Wood pastures
Costs
Wooden fencing

description: Invisible fencing is an innovation that allows the control of cattle movement without needing physical barriers. In open areas, cattle can be fitted with a Geographical Positioning System (GPS) which will signal when a cow approaches a boundary. Under trees in a wood pasture, due to the intermittent GPS signal, an alternative method is to bury an electric cable in the soil surface that emits a shortwave radio signal which is sensed by a transponder on a cattle collar. The transponder emits a noise as a cow approaches the boundary and, if she does not turn back, it provides an electric pulse similar to an electric fence. At Epping Forest, each collar also includes a GPS sensor which helps to locate the cattle.
An Impact Assessment of Weather Changes on Yield and Price for Chinese cabbage and Korean radish
Creators: name: Choi, Byungok
name: Choi, Byungok
Publisher: name: Unknown
Year: 2020
Subjects: subject: Environmental Economics and Policy
subject: Meteorological Environment
subject: Time Series Data
subject: Yield Functions

description: This study targeted two purposes. Firstly, we examined the effect of climate changes on crop changes such as Chinese cabbages and Korean radishes, which are typically grown in unprotected farm fields. Through this examination, we intended to estimate cabbage and Korean radish yield models reflecting relevant weather factors and examine the effect on cabbage and Korean radish yields. Secondly, we aimed to assess the time series model of cabbages and Korean radishes, reflecting seasonal features to examine characteristics of price changes and find out which climate changes occur when prices significantly change. The result of this study will contribute to examining what climate changes occur in the season and when the price of Chinese cabbages and Korean radishes dramatically changes. We believe that our accomplishment will help the government establish preemptive strategies for stabilized supply and demand of Chinese cabbages and Korean radishes.
Blood gene expression signatures predict exposure levels
Creators: name: Wilson, R. E.
name: Ward, S. M.
name: Chou, J. W.
name: Huang, L.
name: Li, J.
name: Heinloth, A. N.
name: Watkins, P. B.
name: Russo, M. W.
name: Boorman, G. A.
name: Houle, C. D.
name: Paules, R. S.
name: Bushel, P. R.
name: Tennant, R. W.
name: Malarkey, D. E.
name: Fannin, R. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP) intoxication, the leading cause of liver failure in the U.S. We hypothesized that gene expression patterns derived from blood cells would provide useful indicators of acute exposure levels. To test this hypothesis, we used a blood gene expression data set from rats exposed to APAP to train classifiers in two prediction algorithms and to extract patterns for prediction using a profiling algorithm. Prediction accuracy was tested on a blinded, independent rat blood test data set and ranged from 88.9% to 95.8%. Genomic markers outperformed predictions based on traditional clinical parameters. The expression profiles of the predictor genes from the patterns extracted from the blood exhibited remarkable (97% accuracy) transtissue APAP exposure prediction when liver gene expression data were used as a test set. Analysis of human samples revealed separation of APAP-intoxicated patients from control individuals based on blood expression levels of human orthologs of the rat discriminatory genes. The major biological signal in the discriminating genes was activation of an inflammatory response after exposure to toxic doses of APAP. These results support the hypothesis that gene expression data from peripheral blood cells can provide valuable information about exposure levels, well before liver damage is detected by classical parameters. It also supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage.
Implementación de la gamificación en el aula de clase para otorgar de sentido y significado el número natural en niños de primer grado de la Institución Educativa Ramón Múnera Lopera sede Alto de la Cruz.
Creators: name: Franco Castro, Natalia
Publisher: name: Universidad de Cartagena
Year: 2023
Subjects: subject: Juegos por Computador
subject: Matemática - Aprendizaje
subject: Matemáticas - Enseñanza con ayuda de computadores

description: Este proyecto tiene como objeto analizar cómo los estudiantes de primer grado otorgan sentido y el significado de los números naturales a través de las prácticas matemáticas implementadas mediante la gamificación en el aula de clase. Utilizando este marco teórico, se analizan las prácticas matemáticas que los estudiantes llevan a cabo al resolver situaciones planteadas desde la gamificación en el aula. Estas categorías permiten examinar de manera detallada las diferentes dimensiones involucradas en las prácticas matemáticas de los estudiantes. En las cuales se analizó que los estudiantes otorgan más sentidos y significados en el contexto de conteo y que es necesario que implementar en el aula de clase situaciones de aula implementando los demás contextos de uso.
Multi-functional hedgerows in the bocage systems of France
Creators: name: Thenail, Claudine
name: Aviron, Stéphanie
name: Viaud, Valérie
name: Guéhenneuc, Thierry
name: Menguy, Cyrille
Publisher: name: Zenodo
Year: 2017
Subjects: Hedgerows
Bocage agroforestry

description: In Brittany, the main period for creating the bocage landscape stretched from late 18th Century to early 20th Century. The hedgerows drew on the discontinuities of the physical environment; they signified the limits of ownership or use, while delivering fuel and timber wood for local and regional use. During the last 50 years, agricultural and broader rural changes have led to the deconstruction of the bocage and to the loss of ecological functions it provides. To date, initiatives of bocage restoration have primarily emphasised the value of hedgerows as providers of environmental services rather than productive resources, and creates a problem in terms of sustainability.The principle of bocage agroforestry is to develop a holistic approach, whereby hedgerows are considered as multi-functional components of landscapes and agricultural systems. This requires a change in both mindset and practices.
Feasibility study of a single-score Life-Cycle Assessment for Space missions: preliminary results.
Creators: name:  MARNIX VERKAMMEN
name:   HAKAN SVEDHEM
name:    ALESSANDRA MENICUCCI
name:   MATHIEU UDRIOT
name:   ADRIEN SAADA
name:   EMMANUELLE DAVID
name:   ANDREW WILSON
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: LIFE-CYCLE ASSESSMENT
SUSTAINABILITY
SPACE MISSION
ENVIRONMENT
SUSTAINABILITY RATING
MODULE
METHODOLOGY
SPACE DEBRIS
BIOSPHERE

description: With a continuously growing number of satellites in orbit, it becomes increasingly important to assess their impacts on the Earth\'s environment in a standardised manner. While interest in Life Cycle Assessment (LCA) for space missions has gained in strength in the past few years -particularly in Europe -no consensus has yet been reached on a single-score LCA system. In parallel however, scoring systems for other sustainability aspects have been defined and are increasingly being used in the industry. A notable example is that of the Swiss-based Space Sustainability Rating (SSR) non-profit organization. It aims to incentivise sustainable behaviors in space through a quantitative and qualitative assessment of the sustainability level of a mission. Several criteria are considered for this such as collision avoidance, post-mission disposal strategy, compliance to existing space debris mitigation standards, detectability and trackability, data sharing, and readiness level to active removal. This paper presents the preliminary results of a feasibility study for creating a single-score LCA module of the SSR. The focus of the study lies in the identification of the initial inputs and the methodology to assess them, as well as the weighting method to reach a single-score. A global survey, with a European focus, has been conducted for this study and its conclusions are used to provide an initial discussion on the weighting method to be used. Overall, this paper highlights the importance of an easy-to-understand LCA tool for space systems. It shows the necessity for a tool that is implementable during the design phase of the mission, to incentivise space actors to opt for more sustainable materials and designs, and to reassess their logistics. To that effect, this paper presents a literature review about LCA, explores consensus-based weights for a single score, highlights perceived benefits and drawbacks of doing a space LCA, investigates new weights for SSR and underlines the main aspects which still need further development and investigation.