cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Screening for common eye diseases in the elderly with Optos ultra-wide-field scanning laser ophthalmoscopy: a pilot study with focus on ocular toxoplasmosis
Creators: name: Logroño Wiese, Pablo Eduardo
name: Seeber, Frank
name: Endres, Anne-Sophie
name: Brockmann, Claudia
name: Pleyer, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Geriatric screening
subject: Ocular toxoplasmosis
subject: T. gondii
subject: Ultra-wide-field scanning laser ophthalmoscopy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose Studies on the occurrence of ocular toxoplasmosis (OT) in a general population are rare. Therefore, we conducted this pilot study to assess whether a nonmydriatic ultra-wide-field (UWF) scanning laser ophthalmoscope (SLO) is suitable for a simple, rapid screening procedure. Methods The population of this cross-sectional study was randomly recruited from a cohort of hospital-based patients in an urban geriatric hospital. Ophthalmologic evaluation was performed on 201 eyes from 101 participants through nonmydriatic UWF-SLO (Optos Daytona) and assessed for suspicious lesions and other relevant ocular findings. All images were evaluated by two independent examiners. Individuals who presented lesions with a morphological appearance suggestive of OT underwent fundoscopy and serological analysis of Toxoplasma gondii-specific antibodies. Results The mean age of the study group was 76 years, and 63 (62%) were female. Despite many health restrictions, the SLO examination was carried out easily in this geriatric population. Three participants presented findings by SLO suspicious for T. gondii-related injury. Further clinical examination and serological investigation confirmed the diagnosis, with funduscopic evaluation and positive T. gondii ELISA testing. In addition, a high rate of arterial hypertension and dyslipidemias within the cohort led to a high incidence of vascular changes and age-related fundus findings. Conclusion In our study, we confirm that UWF-SLO technology is helpful in the rapid detection of peripheral retinal injuries in elderly patients such as OT and may be used as a routine screening tool.
title: Three Essays in Empirical Historical Economics
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2022
Subjects: subject: Ethiopia
subject: Hundred Years War
subject: Printing press
subject: Economic history

description: In recent years text analysis and geographic information systems (GIS) have become vital as sources of data for economic research. In this dissertation I use these tools in conjunction with economic theory to investigate several historical questions. In the first chapter, text matching tools are used in the construction of a database of early European printed materials to explain why some cities adopted the printing press earlier than others during the 15th century. In the second chapter, GIS tools are used to construct a panel of environmental controls to assess the impact of a land redistribution on agricultural productivity in Ethiopia. In the final chapter, both sets of tools are used to explore a database of English soldier names from the 14th and 15th centuries and assess the importance of social status and regional recruitment in the armies of the Hundred Years' War.
Modelling of flexibility-centric energy systems: Operation, planning and policy-making
Creators: name: Schledorn, Amos
Publisher: name: Zenodo
Year: 2023

description: The climate crisis, caused by air pollution through fossil fuel combustion, is an existential threat to billions of people. The global energy sector is responsible for a substantial share of this pollution, making its decarbonisation essential in stopping the climate crisis.Decarbonised energy systems are supplied by renewable energy sources, which are largely variable and uncertain. To maintain the balance of demand and supply in these systems, flexibility across time, space and sectors must be utilised.Such flexibility must be adequately represented in all stages of energy system analysis. Thus, this dissertation addresses the mathematical modelling and optimisation of flexibility-centric energy systems across their operation, planning and policymaking. This is done across different geographical scopes ranging from small-scale to large-scale studies.Residential energy system operation is addressed in introducing a novel home energy management system model that optimises the operation of home battery systems under uncertain electric load. It allows smart home residents to make a trade-off between cost and emission minimisation without expressing their preferences a-priori.District heating systems constitute a substantial source of energy flexibility. I propose an optimisation model for stochastic block bidding for combined heat-and power generation. Through that model, district heating systems can participate in electricity markets more efficiently.Flexibility from energy end-use must also be considered in the planning stage. Yet, the existing body of research does not account for end-user characteristics in modelling demand response. Hence, Frigg, a modelling approach for integrating pricebased, non-linear demand response models into energy system planning, is introduced. This approach allows for better representation of end-user flexibility in energy system planning. It is applied in a case study on flexibility from electrified heating in a future Danish electricity system. Study results suggest both heat storage and demand response yield substantial cost savings.Finally, ongoing research on cross-border energy flexibility is presented. Here, Ukrainian hydrogen exports to the EU are analysed. Main questions regard the competitiveness of such hydrogen exports in terms of their costs, as well as the impact of hydrogen exports on Ukrainian post-war energy system recovery and decarbonisation. Preliminary results suggest hydrogen exports to significantly impact the Ukrainian energy system, depending on their volume.
title: Kinsey Dialogue Series #4: Claiming Global Space: Global Grassroots Movements
Creators: name: Batliwala, Srilatha
Publisher: name: Center for International Education
Year: 2002
Subjects: subject: Bilingual, Multilingual, and Multicultural Education
subject: Education
subject: Educational Assessment, Evaluation, and Research
subject: Educational Methods

description: The Kinsey Dialogue Series was established in memory of our beloved collegue, David Chapin Kinsey. David touched countless lives in the course of his 40 years as a dedicated, brilliant and outstanding educator, helping people everywhere to inquire, explore and discover the world and themselves. From 1975, David Kinsey served as a faculty member of the School of Education in the Center for International Education at the University of Massachusetts at Amherst. It is our hope that the Kinsey Dialogue Series will uphold his legacy, keeping alive his passionate vision for a better world.
description: The influence of transnational civil society organizations and networks - both civil and uncivil - in global politics and unprecedented. Among them, those dedicated to greater social and economic equity and equality, to human security, ecological sustainability, peace, inclusion, and tolerance, have played a particularly effective role in restructuring the norms that inform policy and regulatory frameworks for the world. Some scholarly analysts grant that they have in fact effectively restructured global politics in visible and lasting ways. For this very reason, perhaps, their legitimacy, accountability and constituency base is being challenged by states, multinational corporations, scholars, and leaders of the powerful global institutions they seek to influence or discipline. These challenges make it imperative that they democratize their own structures and the processes by which they generate their agendas. They also bring into the limelight the emerging set of transnational grassroots networks and movements that are contesting for space in global policy making. These newer entities can teach us a great deal about how to create more grounded, constituency-based, accountable global advocacy structures that embody the right to represent those for whom they speak.
Sacral nerve stimulation in patients with ileal pouch-anal anastomosis
Creators: name: Seifarth, Claudia
name: Slavova, Nadine
name: Degro, Claudius
name: Lehmann, Kai S.
name: Kreis, M. E.
name: Weixler, Benjamin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Fecal incontinence
subject: Ulcerative colitis
subject: Sacral nerve stimulation
subject: IPAA
subject: Proctocolectomy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Functional results after proctocolectomy and ileal pouch-anal anastomosis (IPAA) are generally good. However, some patients suffer from high stool frequency or fecal incontinence. Sacral nerve stimulation (SNS) may represent a therapeutic alternative in these patients, but little is known about indication and results. The aim of this study was to evaluate incontinence after IPAA and demonstrate SNS feasibility in these patients. Methods: This retrospective study includes patients who received a SNS between 1993 and 2020 for increased stool frequency or fecal incontinence after proctocolectomy with IPAA for ulcerative colitis. Proctocolectomy was performed in a two- or three-step approach with ileostomy closure as the last step. Demographic, follow-up data and functional results were obtained from the hospital database. Results: SNS was performed in 23 patients. Median follow-up time after SNS was 6.5 years (min. 4.2-max. 8.8). Two patients were lost to follow-up. The median time from ileostomy closure to SNS implantation was 6 years (min. 0.5-max. 14.5). Continence after SNS improved in 16 patients (69%) with a median St. Marks score for anal incontinence of 19 (min. 4-max. 22) before SNS compared to 4 (0-10) after SNS placement (p = 0.012). In seven patients, SNS therapy was not successful. Conclusion: SNS implantation improves symptoms in over two-thirds of patients suffering from high stool frequency or fecal incontinence after proctocolectomy with IPAA. Awareness of the beneficial effects of SNS should be increased in physicians involved in the management of these patients.
title: Urban Forest Implementation Plans as a Means of Achieving Urban Tree Canopy Goals: Case Studies from the Virginia Region of the Chesapeake Bay Watershed
Creators: name: Greenberg, Patricia Pearl
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Urban tree canopy
subject: Urban forest
subject: Urban forest implementation plans
subject: Chesapeake Bay Watershed
subject: Urban tree canopy goals
subject: Trees

description: Among the considerable benefits of tree biomass, as measured by canopy cover, is watershed pollution reduction. This study uses open-ended interviews to identify effective strategies for achieving urban tree canopy goals within four Chesapeake Bay Watershed (CBW) communities in the Commonwealth of Virginia. The study sites were chosen among those that have obtained urban tree canopy assessments and implementation plans. Three key barriers to implementation are: 1) management and policies that do not emphasize urban forestry programs, 2) lack of funding and staff to implement effective strategies, and 3) development-driven and illegal tree removal. Effective strategies include: one-on-one communication with property owners, business and other entities; strong public-private partnerships; inter-departmental partnerships and alliances with non-profits; tree replacements; physically searching for possible planting sites; and education. If these approaches are to be more widely adopted to improve water quality, CBW communities must have more support to further these strategies. Organizations seeking to help communities increase their tree canopy coverage should develop and pilot test programs that reduce the barriers and harness the strategies identified in this research; this may entail collaboration with academic researchers. Beyond the qualitative results presented here, further research is needed to determine specifically both how these strategies result in substantial change in canopy and how key barriers may be overcome.
Elution study of acrylic monomers from orthodontic materials using high performance liquid chromatography (HPLC)
Creators: name: Kux, Benjamin Jakob
name: Bacigalupo, L. M.
name: Scriba, A.
name: Emmrich, M.
name: Jost-Brinkmann, Paul-Georg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Bisphenol A-glycidyl dimethacrylate
subject: Triethylene glycol dimethacrylate
subject: Urethane dimethacrylate
subject: Adhesives
subject: Orthodontic appliances
subject: fixed
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Main goal of the study was the identification and quantitative analysis of monomer elution from materials commonly used in fixed orthodontic therapy. Studies have shown severe health effects of monomers including cytotoxic, allergenic or mutagenic potential and endocrine changes. This in vitro study focusses primarily on five resins which are usually processed intraorally and remain in the oral cavity long-term. Methods: We tested the elution of monomers from specimens (7.5 mm x 1.5 mm) immersed in artificial saliva at body temperature (37 degrees C) for 30 min to 5 weeks. The used method is in accordance with DIN EN ISO 10993-13. The five tested materials were BrackFix (R) (Voco GmbH, Cuxhaven, Germany), Triad (R) Gel (DeguDent GmbH, Hanau, Germany), and Transbond (TM) XT, LR and Plus (3M Unitek, Monrovia, CA, USA). All aliquots were analyzed using high performance liquid chromatography (HPLC). Data were statistically analyzed. Results: All five analyzed materials eluted substances over a period of 5 weeks. Identified substances included bisphenol A (BPA), triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA). BPA eluted from Transbond (TM) Plus, XT, LR and BrackFix (R). The cumulated mean values after 35 days ranged from 16.04 to 64.83 ppm, depending on the material. TEGDMA eluted with a mean of 688.61 ppm from Transbond (TM) LR. UDMA with a mean of 1682.00 ppm from Triad (R) Gel. For each material the highest concentrations of all these substances were found in the first elution period. Other substances that were not equivocally identified or of low concentration also eluted. Conclusion: Using the described method, it is possible to qualitatively and quantitatively determine the in vitro elution of monomers from orthodontic materials. The concentrations of the substances identified were below the current maximum recommended intake. However, a cumulative effect and low-dose effects should be considered for both patients and dental professionals, especially for young patients. Measures to reduce exposure patients and practitioners are suggested.
Guangdong Qing dai dang an lu [volume 07]
廣東清代檔案錄 [第七冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of archives about Guangdong in Qing dynasty.
Title from label, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
title: Bacterial contamination of irrigation fluid and suture material during ACL reconstruction and meniscus surgery
title: Low infection rate despite increasing contamination over surgery time
titleType: Subtitle
Creators: name: Bartek, Benjamin
name: Winkler, Tobias
name: Garbe, Anja
name: Schelberger, Tarek
name: Perka, Carsten
name: Jung, Tobias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: ACL reconstruction
subject: Meniscus surgery
subject: Infection
subject: Contamination
subject: Prophylaxis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: During knee arthroscopy, irrigation fluid from the surgical site accumulates in the sterile reservoir. Whether these fluid collections and also suture material used during the arthroscopic surgical processes show bacterial contamination over time during surgery remains unclear. The purpose of this study was to determine this contamination rate and to analyze its possible influence on postoperative infection. Materials and methods: In this study, 155 patients were included. Fifty-eight underwent reconstruction of the anterior cruciate ligament (ACL), 63 meniscal surgery and 34 patients combined ACL reconstruction and meniscus repair. We collected pooled samples of irrigation fluid from the reservoir on the sterile drape every 15 min during the surgery. In addition, we evaluated suture material of ACL graft and meniscus repair for bacterial contamination. Samples were sent for microbiological analysis, incubation time was 14 days. All patients were seen in the outpatient department 6, 12 weeks and 12 months postoperatively and examined for clinical signs of infection. Results: A strong statistical correlation (R-2 = 0.81, p = 0.015) was found between an advanced duration of surgery and the number of positive microbiological findings in the accumulated fluid. Suture and fixation material showed a contamination rate of 28.4% (29 cases). Despite the high contamination rate, only one infection was found in the follow-up examinations, caused by Staphylococcus lugdunensis. Conclusion: Since bacterial contamination of accumulated fluid increases over time the contact with the fluid reservoirs should be avoided.
Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity
Creators: name: Kruyer, Anna
name: Parrilla-Carrero, Jeffrey
name: Powell, Courtney
name: Brandt, Lasse
name: Gutwinski, Stefan
name: Angelis, Ariana
name: Chalhoub, Reda M.
name: Jhou, Thomas C.
name: Kalivas, Peter W.
name: Amato, Davide
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: D2-MSN hyperactivity
subject: antipsychotic-induced
subject: behavioral supersensitivity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a problematic consequence of long-term antipsychotic treatment characterized by the emergence of motor abnormalities, refractory symptoms, and rebound psychosis. The underlying mechanisms are unclear and no approaches exist to prevent or reverse these unwanted effects of antipsychotic treatment. Here we demonstrate that behavioral supersensitivity stems from long-lasting pre, post and perisynaptic plasticity, including insertion of Ca2+-permeable AMPA receptors and loss of D2 receptor-dependent inhibitory postsynaptic currents (IPSCs) in D2 receptor-expressing medium spiny neurons (D2-MSNs) in the nucleus accumbens core (NAcore). The resulting hyperexcitability, prominent in a subpopulation of D2-MSNs (21%), caused locomotor sensitization to cocaine and was associated with behavioral endophenotypes of antipsychotic treatment resistance and substance use disorder, including disrupted extinction learning and augmented cue-induced cocaine-seeking behavior. Chemogenetic restoration of IPSCs in D2-MSNs in the NAcore was sufficient to prevent antipsychotic-induced supersensitivity, pointing to an entirely novel therapeutic direction for overcoming this condition.
title: Bylaws: Reston Community Association, "Bylaws," October 21, 1991
Creators: name: Reston Community Association
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Reston (Va.)
subject: Reston Community Association

description: Textual: bylaws, original; 11” x 8.5” (27.9 cm x 21.6 cm)
description: Bylaws for the Reston Community Association dated October 21, 1991. This is a set of bylaws for the Reston Community Association. This document discusses the purpose, objectives, organization, membership and governance procedures for the organization. The Reston Community Association was a community advocacy group for Reston, Virginia. Planned Community Archives Collection, mcd4.10
Supplementary document for Ultrahigh-density 3D Holographic Projection by Scattering-assisted Dynamic Holography - 6310469.pdf
Creators: name: Yu, Panpan
name: Liu, Yifan
name: Wang, Ziqiang
name: Liang, Jinyang
name: Liu, Xingsi
name: Li, Yinmei
name: Qiu, Cheng-Wei
name: Gong, Lei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Classical and Physical Optics

description: Supplementary Figures and Notess
title: Moderately hypofractionated radiotherapy as definitive treatment for localized prostate cancer: Pattern of practice in German-speaking countries
title: A survey of the Prostate Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO) and the Working Party on Radiation Oncology of the German Cancer Society (DKG-ARO)
titleType: Subtitle
Creators: name: Shelan, Mohamed
name: Aebersold, Daniel M.
name: Albrecht, Clemens
name: Böhmer, Dirk
name: Flentje, Michael
name: Ganswindt, Ute
name: Höcht, Stefan
name: Hölscher, Tobias
name: Müller, Arndt-Christian
name: Niehoff, Peter
name: Pinkawa, Michael
name: Schmidt-Hegemann, Nina-Sophie
name: Sedlmayer, Felix
name: Wolf, Frank
name: Zamboglou, Constantinos
name: Zips, Daniel
name: Wiegel, Thomas
name: Ghadjar, Pirus
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Hypofractionation
subject: Prostate cancer
subject: Radiotherapy
subject: Guidelines
subject: Survey
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Various randomized phase III clinical trials have compared moderately hypofractionated to normofractionated radiotherapy (RT). These modalities showed similar effectiveness without major differences in toxicity. This project was conducted by the Prostate Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO) and the Working Party on Radiation Oncology of the German Cancer Society. We aimed to investigate expert opinions on the use of moderately hypofractionated RT as a definitive treatment for localized prostate cancer in German-speaking countries. Methods: A 25-item, web-based questionnaire on moderate-hypofractionation RT was prepared by an internal committee. The experts of the DEGRO were asked to complete the questionnaire. Results: Fourteen active members of DEGRO completed the questionnaire. The questions described indications for selecting patients eligible to receive moderate hypofractionation based on clinical and pathological factors such as age, urinary symptoms, and risk-group. The questions also collected information on the technical aspects of selection criteria, including the definition of a clinical target volume, the use of imaging, protocols for bladder and rectal filling, the choice of a fractionation schedule, and the use of image guidance. Moreover, the questionnaire collected information on post-treatment surveillance after applying moderately hypofractionated RT. Conclusion: Although opinions varied on the use of moderate-hypofractionation RT, the current survey reflected broad agreement on the notion that moderately hypofractionated RT could be considered a standard treatment for localized prostate cancer in German-speaking countries.
title: The Perils of Anonymity
Creators: name: Cohen, Dan
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Academia
subject: Blogs

description: Originally published by Dan Cohen on Dan Cohen's Digital Humanities Blog (www.dancohen.org). This work is licensed under a Creative Commons Attribution 3.0 United States License (http://creativecommons.org/licenses/by/3.0/us/).
title: Interventions that positively impact the performance of students with learning disabilities in secondary general education classrooms
Creators: name: Hughes, Charles A.
name: Maccini, Paula
name: Gagnon, Joseph Calvin
Publisher: name: Learning Disabilities: A Multidisciplinary Journal
Year: 2003
Subjects: subject: Learning disabilities
subject: Instruction
subject: General education curriculum

description: The article discusses strategies for helping secondary students with LD within the general education curriculum. Descriptions of strategies and examples are provided.
title: Putin, Ahmadinejad and the Iranian Nuclear Crisis
Creators: name: Katz, Mark N.
Publisher: name: Blackwell Publishing Ltd
Year: 2007
Subjects: subject: Russia
subject: Ahmadinejad
subject: International affairs
subject: Iran
subject: Nuclear Crisis

description: The definitive version of this document can be found at http://www.blackwell-synergy.com This document was created using OCR technology, and may contain minor discrepancies from the published document.
description: Iranian President Mahmoud Ahmadinejad has presented Moscow with both opportunities and challenges. This article will examine Russian policies toward and views of Iran since his election in June 2005 with regard to the most prominent issue in the Russian- Iranian relationship: the Iranian nuclear crisis. What this analysis will show is that Moscow has become increasingly frustrated with Ahmadinejad. Despite this, however, Moscow is unlikely to support a confrontational American approach to the Iranian nuclear issue, not only out of a desire to prevent the United States from becoming even more dominant, but also out of fear of losing what stakes Russia now has (and hopes to have) in Iran.
Emotional abuse interacts with borderline personality in adolescent inpatients with binge-purging eating disorders
Creators: name: Spiegel, J.
name: Arnold, S.
name: Salbach, H.
name: Gotti, Emma Giordana
name: Pfeiffer, E.
name: Lehmkuhl, U.
name: Correll, Christoph U.
name: Jaite, Charlotte
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Bulimia nervosa
subject: Anorexia nervosa binge-purging
subject: Adolescents
subject: Childhood emotional abuse
subject: Borderline personality
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Childhood abuse is associated with an increased risk of developing eating disorders (EDs) as well as personality disorders (PDs). However, their interaction is still uncertain, particularly in adolescents. This study investigates the correlations between childhood emotional neglect (CEN), childhood emotional abuse (CEA), and obsessive-compulsive and borderline personality styles in female adolescent inpatients with eating disorders (EDs). Methods: One hundred and twenty-eight inpatients (ages 14-18) were assessed, 54 were diagnosed with restricting-type anorexia nervosa (AN-R) and 33 with a binge-purging ED [BP-ED; comprising patients with binge-purging type anorexia nervosa (AN-BP), n = 15, and bulimia nervosa (BN), n = 18]. Fifty healthy participants made up the control group (CG). CEN and CEA were assessed with the Childhood Trauma Questionnaire, while the Personality Style and Disorder Inventory was implemented to determine personality styles. Results: A MANOVA revealed a significant main effect of CEA on spontaneous-borderline personality style [F(8,119) = 17.1, p < 0.001, eta(2) = 0.126], as well as a main effect of ED group on spontaneous-borderline [F(2,119) = 3.1, p = 0.048, eta(2) = 0.050]. A significant interaction between ED group, CEA, and spontaneous-borderline was found [F(2,119) = 3.5, p = 0.034, eta(2) = 0.055] with BP-ED showing significantly higher scores in CEA (9.3 +/- 4.0) and in spontaneous-borderline (14.2 +/- 6.2). Conclusions: Considering CEA and borderline personality style in adolescent inpatients with BN or AN-BP may help improve the understanding of the etiology and maintenance of BP-ED and provide more effective treatment targets.
Guangdong Qing dai dang an lu [volume 08]
廣東清代檔案錄 [第八冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of archives about Guangdong in Qing dynasty.
Title from label, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
Audio-guided self-hypnosis for reduction of claustrophobia during MR imaging: results of an observational 2-group study
Creators: name: Napp, Adriane E.
name: Diekhoff, Torsten
name: Stoiber, Olf
name: Enders, Judith
name: Diederichs, Gerd
name: Martus, Peter
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Phobic disorders
subject: Anxiety
subject: Magnetic resonance imaging
subject: Hypnosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To evaluate the influence of audio-guided self-hypnosis on claustrophobia in a high-risk cohort undergoing magnetic resonance (MR) imaging. Methods: In this prospective observational 2-group study, 55 patients (69% female, mean age 53.6 ± 13.9) used self-hypnosis directly before imaging. Claustrophobia included premature termination, sedation, and coping actions. The claustrophobia questionnaire (CLQ) was completed before self-hypnosis and after MR imaging. Results: were compared to a control cohort of 89 patients examined on the same open MR scanner using logistic regression for multivariate analysis. Furthermore, patients were asked about their preferences for future imaging. Results There was significantly fewer claustrophobia in the self-hypnosis group (16%; 9/55), compared with the control group (43%; 38/89; odds ratio .14; p = .001). Self-hypnosis patients also needed less sedation (2% vs 16%; 1/55 vs 14/89; odds ratio .1; p = .008) and non-sedation coping actions (13% vs 28%; 7/55 vs 25/89; odds ratio .3; p = .02). Self-hypnosis did not influence the CLQ results measured before and after MR imaging (p = .79). Self-hypnosis reduced the frequency of claustrophobia in the subgroup of patients above an established CLQ cut-off of .33 from 47% (37/78) to 18% (9/49; p = .002). In the subgroup below the CLQ cut-off of 0.33, there were no significant differences (0% vs 9%, 0/6 vs 1/11; p = 1.0). Most patients (67%; 35/52) preferred self-hypnosis for future MR examinations. Conclusions: Self-hypnosis reduced claustrophobia in high-risk patients undergoing imaging in an open MR scanner and might reduce the need for sedation and non-sedation coping actions.
Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography
Creators: name: Laskowski, Dominik
name: Feger, Sarah
name: Bosserdt, Maria
name: Zimmermann, Elke
name: Mohamed, Mahmoud
name: Kendziora, Benjamin
name: Rief, Matthias
name: Dreger, Henryk
name: Estrella, Melanie
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Computed tomography angiography
subject: Coronary artery disease
subject: Coronary angiography
subject: Chest pain
subject: Incidental findings
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To compare the detection of relevant extracardiac findings (ECFs) on coronary computed tomography angiography (CTA) and invasive coronary angiography (ICA) and evaluate the potential clinical benefit of their detection. Methods: This is the prespecified subanalysis of ECFs in patients presenting with a clinical indication for ICA based on atypical angina and suspected coronary artery disease (CAD) included in the prospective single-center randomized controlled Coronary Artery Disease Management (CAD-Man) study. ECFs requiring immediate therapy and/or further workup including additional imaging were defined as clinically relevant. We evaluated the scope of ECFs in 329 patients and analyzed the potential clinical benefit of their detection. Results: ECFs were detected in 107 of 329 patients (32.5%; CTA: 101/167, 60.5%; ICA: 6/162, 3.7%; p < .001). Fifty-nine patients had clinically relevant ECFs (17.9%; CTA: 55/167, 32.9%; ICA: 4/162, 2.5%; p < .001). In the CTA group, ECFs potentially explained atypical chest pain in 13 of 101 patients with ECFs (12.9%). After initiation of therapy, chest pain improved in 4 (4.0%) and resolved in 7 patients (6.9%). Follow-up imaging was recommended in 33 (10.0%; CTA: 30/167, 18.0%; ICA: 3/162, 1.9%) and additional clinic consultation in 26 patients (7.9%; CTA: 25/167, 15.0%; ICA: 1/162, 0.6%). Malignancy was newly diagnosed in one patient (0.3%; CTA: 1/167, 0.6%; ICA: 0). Conclusions: In this randomized study, CTA but not ICA detected clinically relevant ECFs that may point to possible other causes of chest pain in patients without CAD. Thus, CTA might preclude the need for ICA in those patients.
Gender trends in authorships and publication impact in Academic Radiology—a 10-year perspective
Creators: name: Molwitz, Isabel
name: Yamamura, Jin
name: Ozga, Ann-Kathrin
name: Wedekind, Ilka
name: Nguyen, Thai-An
name: Wolf, Liesa
name: Kamo, Minobu
name: Zhao, Jing
name: Can, Elif
name: Keller, Sarah
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Authorship
subject: Female
subject: Journal impact factor
subject: Bibliometrics
subject: Publishing
subject: statistics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To analyze the development of publication numbers of female authors in high-, medium-, and low-impact radiological journals. Methods: In this bibliometric analysis, gender of the first (FA) and senior author (SA) was assigned to all original research articles and reviews, published in 10 high-, medium-, and low-impact radiological journals in 2007/8 and 2017/18. The adjusted event rate (AER) and adjusted odds ratio (AOR) were calculated using mixed logistic and multinomial logistic regression models to assess and compare female publications according to impact factor, journal, author position, and combination. Results: The proportion of female FA and female SA in N = 6979 (2007/2008) and N = 7383 (2017/2018) articles increased to 29.1% and 16.1% in 2017/2018, respectively. While most female authorships were continuously observed in medium-impact journals, the strongest increase occurred for both female FA (AOR 2.0; p < .0001) and SA (AOR 2.1; p < .0001) in low-impact journals. Female SA published significantly more often in a low- (AOR 1.5) or medium- (AOR 1.8) than in a high-ranking journal. Among the high-ranking journals, female FA published most frequently in European Radiology (32.4%; 95% CI [29.3-35.8]; p < .0001), female SA in Investigative Radiology (15.9%; 95% CI [13.7-18.4]; p < .0001). Male same-sex authorships decreased (AOR 0.9), but remained at least twice as common as all-female or mixed authorships. Conclusion: The increase in female authorship is reflected in all impact areas. Female FA and SA increased most in low-ranking journals but are most common in medium-ranking journals. Female SA remain rare, especially in high impact journals.
Patient-specific risk profile associated with early-onset primary osteoarthritis of the shoulder: is it really primary?
Creators: name: Plachel, Fabian
name: Akgün, Doruk
name: Imiolczyk, Jan-Philipp
name: Minkus, Marvin
name: Moroder, Philipp
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Primary glenohumeral osteoarthritis
subject: Risk profile
subject: Young population
subject: Eccentric osteoarthritis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction Although age is considered to be the major risk factor of primary glenohumeral osteoarthritis (GOA), younger population may suffer from degenerative changes of the shoulder joint without evidence of any leading cause. The purpose of this study was to investigate the risk profile in young patients suffering from presumably primary GOA. Methods A consecutive group of 47 patients undergoing primary shoulder arthroplasty for early-onset GOA below the age of 60 years at time of surgery was retrospectively identified and prospectively evaluated. Patients with identifiable cause for GOA (secondary GOA) were excluded. The resulting 32 patients (mean age 52 +/- 7 years; 17 male, 15 female) with primary GOA were matched by age (+/- 3 years) and gender to 32 healthy controls (mean age 53 +/- 7 years; 17 male, 15 female). Demographic data and patient-related risk factors were assessed and compared among both groups to identify extrinsic risk factors for primary GOA. Patients were further subdivided into a group with concentric GOA (group A) and a group with eccentric GOA (group B) to perform a subgroup analysis. Results Patients had a significantly higher BMI (p = 0.017), were more likely to be smokers (p < 0.001) and to have systematic diseases such as hypertension (p = 0.007) and polyarthritis (p < 0.001) and a higher Shoulder Activity Level (SAL) (p < 0.001) when compared to healthy controls. Furthermore, group B had a significantly higher SAL not only compared to healthy controls but also to group A, including activities such as combat sport (p = 0.048) and weightlifting (p = 0.01). Conclusions Several patient-specific risk factors are associated with primary GOA in the young population, as well as highly shoulder demanding activities in the development of eccentric GOA. Consequently, a subset of young patients with eccentric primary GOA could in reality be secondary due to a muscular imbalance between internal and external rotators caused by improper weight training.
ESUR/ESUI position paper: developing artificial intelligence for precision diagnosis of prostate cancer using magnetic resonance imaging
Creators: name: Penzkofer, Tobias
name: Padhani, Anwar R.
name: Turkbey, Baris
name: Haider, Masoom A.
name: Huisman, Henkjan
name: Walz, Jochen
name: Salomon, Georg
name: Schoots, Ivo G.
name: Richenberg, Jonathan
name: Villeirs, Geert
name: Panebianco, Valeria
name: Rouviere, Olivier
name: Logager, Vibeke Berg
name: Barentsz, Jelle
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Artificial intelligence
subject: Deep learning
subject: Prostate cancer
subject: Multiparametric magnetic resonance imaging
subject: Image-guided biopsy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Artificial intelligence developments are essential to the successful deployment of community-wide, MRI-driven prostate cancer diagnosis. AI systems should ensure that the main benefits of biopsy avoidance are delivered while maintaining consistent high specificities, at a range of disease prevalences. Since all current artificial intelligence / computer-aided detection systems for prostate cancer detection are experimental, multiple developmental efforts are still needed to bring the vision to fruition. Initial work needs to focus on developing systems as diagnostic supporting aids so their results can be integrated into the radiologists' workflow including gland and target outlining tasks for fusion biopsies. Developing AI systems as clinical decision-making tools will require greater efforts. The latter encompass larger multicentric, multivendor datasets where the different needs of patients stratified by diagnostic settings, disease prevalence, patient preference, and clinical setting are considered. AI-based, robust, standard operating procedures will increase the confidence of patients and payers, thus enabling the wider adoption of the MRI-directed approach for prostate cancer diagnosis.
Guangdong Qing dai dang an lu [volume 04]
廣東清代檔案錄 [第四冊]
Creators: name: (:Null)
Publisher: name: The University of British Columbia
Year: 2016

description: A handwritten copy of archives about Guangdong in Qing dynasty.
Title from label, on double leaves, East Asian binding. Sealed by Yao Junshi.
Edition: [Chao ben]
Supplementary document for Pulse-to-pulse field characterization at X-ray free-electron lasers using a speckle-correlation scattering matrix - 6310534.pdf
Creators: name: Lee, KyeoReh
name: Park, YongKeun
name: Lim, Jun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement Information
Accuracy of fractal analysis and PI-RADS assessment of prostate magnetic resonance imaging for prediction of cancer grade groups: a clinical validation study
Creators: name: Michallek, Florian
name: Huisman, Henkjan
name: Hamm, Bernd
name: Elezkurtaj, Sefer
name: Maxeiner, Andreas
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Prostatic neoplasms
subject: Neoplasm grading
subject: Perfusion
subject: Fractals
subject: Multiparametric magnetic resonance imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: Multiparametric MRI with Prostate Imaging Reporting and Data System (PI-RADS) assessment is sensitive but not specific for detecting clinically significant prostate cancer. This study validates the diagnostic accuracy of the recently suggested fractal dimension (FD) of perfusion for detecting clinically significant cancer. Materials and methods: Routine clinical MR imaging data, acquired at 3 T without an endorectal coil including dynamic contrast-enhanced sequences, of 72 prostate cancer foci in 64 patients were analyzed. In-bore MRI-guided biopsy with International Society of Urological Pathology (ISUP) grading served as reference standard. Previously established FD cutoffs for predicting tumor grade were compared to measurements of the apparent diffusion coefficient (25th percentile, ADC(25)) and PI-RADS assessment with and without inclusion of the FD as separate criterion. Results: Fractal analysis allowed prediction of ISUP grade groups 1 to 4 but not 5, with high agreement to the reference standard (kappa(FD) = 0.88 [CI: 0.79-0.98]). Integrating fractal analysis into PI-RADS allowed a strong improvement in specificity and overall accuracy while maintaining high sensitivity for significant cancer detection (ISUP > 1; PI-RADS alone: sensitivity = 96%, specificity = 20%, area under the receiver operating curve [AUC] = 0.65; versus PI-RADS with fractal analysis: sensitivity = 95%, specificity = 88%, AUC = 0.92, p < 0.001). ADC(25) only differentiated low-grade group 1 from pooled higher-grade groups 2-5 (kappa(ADC) = 0.36 [CI: 0.12-0.59]). Importantly, fractal analysis was significantly more reliable than ADC(25) in predicting non-significant and clinically significant cancer (AUC(FD) = 0.96 versus AUC(ADC) = 0.75, p < 0.001). Diagnostic accuracy was not significantly affected by zone location. Conclusions: Fractal analysis is accurate in noninvasively predicting tumor grades in prostate cancer and adds independent information when implemented into PI-RADS assessment. This opens the opportunity to individually adjust biopsy priority and method in individual patients.
title: Characterizing the Effect of Bortezomib on Rift Valley Fever Virus Multiplication
Creators: name: Keck, Forrest David
Publisher: name: George Mason University
Year: 2015
Subjects: subject: Rift Valley Fever Virus
subject: Ubiquitin proteasome system
subject: NSs
subject: SAP30
subject: MSin3A
subject: IFN-B

description: This work was embargoed by the author and will not be publicly available until October 2015.
description: This thesis investigates the FDA-approved cancer drug Bortezomib; characterizing its use as a novel application in Bunyavirus antiviral therapy. Rift Valley Fever virus (RVFV) belongs to the family Bunyaviridae and is a known cause of epizootics and epidemics in Africa and the Middle East. With no FDA approved therapeutics available to treat RVFV infection, understanding the interactions between the virus and the infected host is crucial to developing novel therapeutic strategies. Here, we investigated the requirement of the ubiquitin-proteasome system (UPS) for the establishment of a productive RVFV infection. It was previously shown that the UPS plays a central role in RVFV multiplication involving degradation of PKR and p62 subunit of TFIIH. Using the FDA-approved proteasomal inhibitor Bortezomib, we observed robust inhibition of intracellular and extracellular viral loads. Bortezomib treatment did not affect the nuclear/cytoplasmic distribution of the non-structural protein NSs; however, the ability of NSs to form nuclear filaments was abolished as a result of Bortezomib treatment. In silico ubiquitination prediction analysis predicted that known NSs interactors (SAP30, YY1, and mSin3A) have multiple putative ubiquitination sites, while NSs itself was not predicted to be ubiquitinated. Immunoprecipitation studies indicated a decrease in interaction between SAP30 – NSs, and mSin3A – NSs in the context of Bortezomib treatment. This decrease in association between SAP30 - NSs also correlated with a decrease in the ubiquitination status of SAP30 with Bortezomib treatment. Bortezomib treatment, however; resulted in increased ubiquitination of mSin3A, suggesting that Bortezomib dynamically affects the ubiquitination status of host proteins that interact with NSs. Finally, we observed that expression of interferon beta (IFN-β) was increased in Bortezomib treated cells which indicated that the cellular antiviral mechanism was revived as a result of treatment and may contribute to control of viral multiplication.
Comparison of low-contrast detectability between uniform and anatomically realistic phantoms—influences on CT image quality assessment
Creators: name: Conzelmann, Juliane
name: Genske, Ulrich
name: Emig, Arthur
name: Scheel, Michael
name: Hamm, Bernd
name: Jahnke, Paul
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Tomography, X-ray computed
subject: Phantoms, imaging
subject: Medical physics
subject: Neck
subject: Radiation protection
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objectives: To evaluate the effects of anatomical phantom structure on task-based image quality assessment compared with a uniform phantom background. Methods: Two neck phantom types of identical shape were investigated: a uniform type containing 10-mm lesions with 4, 9, 18, 30, and 38 HU contrast to the surrounding area and an anatomically realistic type containing lesions of the same size and location with 10, 18, 30, and 38 HU contrast. Phantom images were acquired at two dose levels (CTDIvol of 1.4 and 5.6 mGy) and reconstructed using filtered back projection (FBP) and adaptive iterative dose reduction 3D (AIDR 3D). Detection accuracy was evaluated by seven radiologists in a 4-alternative forced choice experiment. Results: Anatomical phantom structure impaired lesion detection at all lesion contrasts (p < 0.01). Detectability in the anatomical phantom at 30 HU contrast was similar to 9 HU contrast in uniform images (91.1% vs. 89.5%). Detection accuracy decreased from 83.6% at 5.6 mGy to 55.4% at 1.4 mGy in uniform FBP images (p < 0.001), whereas AIDR 3D preserved detectability at 1.4 mGy (80.7% vs. 85% at 5.6 mGy, p = 0.375) and was superior to FBP (p < 0.001). In the assessment of anatomical images, superiority of AIDR 3D was not confirmed and dose reduction moderately affected detectability (74.6% vs. 68.2%, p = 0.027 for FBP and 81.1% vs. 73%, p = 0.018 for AIDR 3D). Conclusions: A lesion contrast increase from 9 to 30 HU is necessary for similar detectability in anatomical and uniform neck phantom images. Anatomical phantom structure influences task-based assessment of iterative reconstruction and dose effects.