cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Facet joints: forgotten area
Creators: name: Drozdova, Julia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neuroradiology spine
subject: CNS
subject: MR
subject: CT
subject: Imaging sequences
subject: Arthritides
subject: Education and training
subject: Image verification

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: to discuss pathology of facet joints that can be a reason for low back...
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Creators: name: Senisterra, Guillermo
name: Brown, Peter J.
name: Chau, Irene
name: Chen, Xin
name: Arrowsmith, Cheryl H.
name: Jin, Jian
name: Liu, Feng
name: Wasney, Gregory A.
name: Vedadi, Masoud
name: Herold, J. Martin
name: Dong, Aiping
name: Jadhav, Ajit
name: Kireev, Dmitri B.
name: Quinn, Amy M.
name: Kozieradzki, Ivona
name: Barsyte, Dalia
name: Siarheyeva, Alena
name: Allali-Hassani, Abdellah
name: Frye, Stephen V.
name: Simeonov, Anton
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template led to the discovery of 8 (UNC0224) as a potent and selective G9a inhibitor. A high resolution X-ray crystal structure of the G9a-8 complex, the first co-crystal structure of G9a with a small molecule inhibitor, was obtained. The co-crystal structure validated our binding hypothesis and will enable structure-based design of novel inhibitors. 8 is a useful tool for investigating the biology of G9a and its roles in chromatin remodeling.
The Spitzer Local Volume Legacy (LVL) Global Optical Photometry
Creators: name: Cook, David O.
name: Dale, Daniel A.
name: Johnson, Benjamin D.
name: Van Zee, Liese
name: Lee, Janice C.
name: Kennicutt, Robert C.
name: Calzetti, Daniela
name: Staudaher, Shawn M.
name: Engelbracht, Charles W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the global optical photometry of 246 galaxies in the Local Volume Legacy (LVL) survey. The full volume-limited sample consists of 258 nearby (D < 11 Mpc) galaxies whose absolute B-band magnitude span a range of -9.6 < M_B < -20.7 mag. A composite optical (UBVR) data set is constructed from observed UBVR and SDSS ugriz imaging, where the ugriz magnitudes are transformed into UBVR. We present photometry within three galaxy apertures defined at UV, optical, and IR wavelengths. Flux comparisons between these apertures reveal that the traditional optical R25 galaxy apertures do not fully encompass extended sources. Using the larger IR apertures we find color-color relationships where later-type spiral and irregular galaxies tend to be bluer than earlier-type galaxies. These data provide the missing optical emission from which future LVL studies can construct the full panchromatic (UV-optical-IR) spectral energy distributions.
description: Accepted for publication in MNRAS (9 pages, 5 figures, 5 tables)
Lattice Radiation Therapy in clinical practice: a systematic review
Creators: name: Iori, Federico
name: Cappelli, Anna
name: Elisa, D'Angelo
name: Cozzi, Salvatore
name: Ghersi, Sebastiano
name: De Felice Francesca,
name: Ciammella, Patrizia
name: Bruni, Alessio
name: Iotti, Cinzia
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: ABSTRACT Purpose: Lattice radiation therapy (LRT) is an innovative type of spatially fractionated radiation therapy. It aims to increase large tumors control probability by administering ablative doses without an increased toxicity. Considering the rising number of positive clinical experiences, the objective of this work is to evaluate LRT safety and efficacy. Method: Reports about LRT clinical experience were identified with a systematic review conducted on 4 different databases (namely, Medline, Embase, Scopus, and Cochrane Library) through the August 2022. Only LRT clinical reports published in English and with the access to the full manuscript text were considered as eligible. The 2020 update version PRISMA statement was followed. Results: Data extraction was performed from 11 eligible records encompassing 7 case reports, 1 case series, and 3 clinical studies. 80 patients (83 lesions) with a large lesion ranging from 63.2 cc to 3713.5 cc were subjected to exclusive, hybrid, and metabolism guided LRT. Excluding one G4 toxicity possibly related with LRT, no G3 toxicity was reported. When a complete response was not achieve 3-6 months after LRT, a median lesion reduction approximately ≥ 50% was registered. Conclusion: This systematic review suggests LRT safety, especially for exclusive LRT. The very low level of evidence and the study heterogeneity preclude drawing definitive conclusions on LRT efficacy even though an interesting trend in terms of lesions reduction has been described.
Leibniz seminorms in probability spaces
Creators: name: Besenyei, Adam
name: Leka, Zoltan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 46L53, 60E15, Secondary 26A51, 60B99

description: In this paper we study the (strong) Leibniz property of centered moments of bounded random variables. We shall answer a question raised by M. Rieffel on the non-commutative standard deviation.
description: 10 pages
Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure−Activity Relationship Modeling, Virtual Screening, and Experimental Validation
Creators: name: Wang, Xiang S.
name: Tropsha, Alexander
name: Peterson, Yuri K.
name: Casey, Patrick J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Geranylgeranylation is critical to the function of several proteins including Rho, Rap1, Rac, Cdc42, and G-protein gamma subunits. Geranylgeranyltransferase type I (GGTase-I) inhibitors (GGTIs) have therapeutic potential to treat inflammation, multiple sclerosis, atherosclerosis, and many other diseases. Following our standard QSAR modeling workflow, we have developed and rigorously validated Quantitative Structure Activity Relationship (QSAR) models for 48 GGTIs using variable selection k nearest neighbor (kNN), automated lazy learning (ALL), and partial least square (PLS) methods. The QSAR models were employed for virtual screening of 9.5 million commercially available chemicals yielding 47 diverse computational hits. Seven of these compounds with novel scaffolds and high predicted GGTase-I inhibitory activities were tested in vitro, and all were found to be bona fide and selective micromolar inhibitors. Notably, these novel hits could not be identified using traditional similarity search. These data demonstrate that rigorously developed QSAR models can serve as reliable virtual screening tools.
title: Evaluation of digital X-ray image quality depending on the change of X-ray tube voltage and current at the same irradiation dose.
Creators: name: YOO, BYEONG CHEON
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Perception image
subject: Digital radiography
subject: Radiographers
subject: Image verification

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: This study evaluates the change of X-ray Image quality due to changes kVp and mAs at the same irradiation...
Lacosamide Isothiocyanate-Based Agents: Novel Agents To Target and Identify Lacosamide Receptors
Creators: name: Park, Ki Duk
name: Kohn, Harold
name: Morieux, Pierre
name: Reamtong, Onrapak
name: Salomé, Christophe
name: Eyers, Claire
name: Liu, Rihe
name: Cotten, Steven W.
name: Stables, James P.
name: Gaskell, Simon J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: (R)-Lacosamide ((R)-2, (R)-N-benzyl 2-acetamido-3-methoxypropionamide), has recently gained regulatory approval for the treatment of partial-onset seizures in adults. Whole animal pharmacological studies have documented that (R)-2 function is unique. A robust strategy is advanced for the discovery of interacting proteins associated with function and toxicity of (R)-2 through the use of (R)-2 analogs, 3, that contain “affinity bait (AB)” and “chemical reporter (CR)” functional groups. In 3, covalent modification of the interacting proteins proceeds at the AB moiety, and detection or isolation of the selectively captured protein occurs through the bioorthogonal CR group upon reaction with an appropriate probe. We report the synthesis, pharmacological evaluation, and interrogation of the mouse soluble brain proteome using 3 where the AB group is an isothiocyanate moiety. One compound, (R)-N-(4-isothiocyanato)benzyl 2-acetamido-3-(prop-2-ynyloxy)propionamide ((R)-9), exhibited excellent seizure protection in mice and, like (R)-2, anticonvulsant activity principally resided in the (R)-stereoisomer. Several proteins were preferentially labeled by (R)-9 compared with (S)-9, including collapsin response mediator protein 2.
title: Continuous infusion of hypertonic saline in monopolar radiofrequency ablation in order to increase ablation defect volume
Creators: name: Schicho, Andreas
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Interventional non-vascular
subject: Oncology
subject: CT
subject: Ablation procedures
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Radiofrequency ablation (RFA) is a minimal-invasive treatment option for liver malignancies, e.g. hepatocellular carcinoma or metastases. With the help of computed tomography or ultrasound, an electrode is inserted into the hepatic malignancy. A...
title: Emergency call after renal trasplantation: don’t press the panic button
Creators: name: OTERINO SERRANO, CÉSAR
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Kidney
subject: Abdomen
subject: CT
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Complications
subject: Diagnostic procedure
subject: Transplantation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To go over normal findings after recent transplantation. 2. To review early complications classification and frequency. 3. To illustrate their radiologic features with US and CT...
Additional file 1 of Modifiable factors associated with postoperative atrial fibrillation in older patients with hip fracture in an orthogeriatric care pathway: a nested case–control study
Creators: name: Gay, Pierre
name: Genet, Bastien
name: Rouet, Audrey
name: Alkouri, Rana
name: Cohen-Bittan, Judith
name: Boddaert, Jacques
name: Zerah, Lorène
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. STROBE Statement—Checklist of items that should be included in reports of cohort studies.
Countable homogeneous lattices
Creators: name: Abogatma, A.
name: Truss, J. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 06A99

description: We show that there are uncountably many countable lattices. We give a discussion of which such lattices can be modular or distributive. The method applies to show that certain other classes of structures also have uncountably many homogeneous structures
description: 4 pages The final publication is available at Springer via http://dx.doi.org/10.1007/s11083-014-9328-6
title: The development, standardisation and validation of an instrument designed to measure coping with chronic pain
Creators: name: J. Ghadiali, E.
Publisher: name: University of Liverpool Repository
Year: 2023

description: The purpose of the study was to investigate the structure of coping with chronic pain and to develop a standardised, reliable and valid ~t to measure coping with chronic pain. The use of this instrument as a measure of change in the evaluation of a local Pain Management Programe was investigated. The Pain Coping Questionnaire was developed from analysis of responses of 298 chronic pain patients to a self-report questionnaire concerned with coping with chronic pain. Following empirical psychometric investigations of reliability and validity, four psychologically meaningful dimensions were identified. One dimension, the General Coping Measure, was a measure of psycho-social adjustment to chronic pain. Three dimensions measured beliefs in the use of cognitive and behavioural pain coping strategies. One dimension, Active Coping Strategies, measured active pain coping strategies. Two dimensions, Avoidance and Use of Drugs, measured passive pain coping strategies. Belief in the use of active pain coping strategies was predictive of good psycho-social adjustment. Belief in the use of passive pain coping strategies was predictive of poor psycho-social adjustment. The results from outco~e studies indicated that the Pain Coping Questionnaire was a sensitive measure of change. The Pain Manag~.ment Programne had beneficial effects with respect to short-term outcome. Limitations were discussed. It was concluded that the Pain Coping Questionnaire represents an original contribution that is likely to have broad applications in the assessment and treatment of chronic pain patients.
Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-κB Pathways
Creators: name: Hong, Tse-Ming
name: Shi, Qian
name: Yang, Pan-Chyr
name: Lee, Kuo-Hsiung
name: Wei, Linyi
name: Yu, Sung-Liang
name: Chen, Hsuan-Yu
name: Lin, Jau-Chen
name: Yang, Shuenn-Chen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Tylophorine and related natural compounds exhibit potent antitumor activities. We previously showed that PBT-1, a synthetic C9-substituted phenanthrene-based tylophorine (PBT) derivative, significantly inhibits growth of various cancer cells. In this study, we further explored the mechanisms and potential of PBT-1 as an anticancer agent. PBT-1 dose-dependently suppressed colony formation, induced cell cycle G2/M arrest and apoptosis. DNA microarray and pathway analysis showed that PBT-1 activated the apoptosis pathway and mitogen-activated protein kinase signaling. In contrast, PBT-1 suppressed the nuclear factor kappaB (NF-κB) pathway and focal adhesion. We further confirmed that PBT-1 suppressed Akt activation accelerated RelA degradation via IκB kinase-α, and downregulated NF-κB target gene expression. The reciprocal recruitment of RelA and RelB on COX-2 promoter region led to downregulation of transcriptional activity. We conclude that PBT-1 induces cell cycle G2/M arrest and apoptosis by inactivating Akt and by inhibiting the NF-κB signaling pathway. PBT-1 may be a good drug candidate for anticancer chemotherapy.
Additional file 2 of Modifiable factors associated with postoperative atrial fibrillation in older patients with hip fracture in an orthogeriatric care pathway: a nested case–control study
Creators: name: Gay, Pierre
name: Genet, Bastien
name: Rouet, Audrey
name: Alkouri, Rana
name: Cohen-Bittan, Judith
name: Boddaert, Jacques
name: Zerah, Lorène
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Answers of 9 atrial fibrillation experts to the question: “According to you, what are the 9 or 10 main baseline predisposing factors of POAF among patients of 70 and more undergoing HF surgery?”
Evaluation of mental health symptoms as moderators of the relationship between drinking identity and hazardous drinking
Creators: name: Lindgren, Kristen
name: Neighbors, Clayton
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Mental and Social Health
subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences

description: This is a secondary data analysis. This project will investigate mental health symptoms as moderators of the relationship between drinking identity and hazardous drinking; evaluate implicit and explicit drinking identity and mental health symptoms at between and within-person levels to evaluate both dispositional and fluctuating aspects of drinking identity and mental health symptoms; evaluate interactions and their relationship to indicators of hazardous drinking (alcohol consumption and alcohol-related problems)
title: Bridging between diploma and undergraduate radiography education: development of a short programme of study
Creators: name: Alvey, Christopher
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Professional issues
subject: Conventional radiography
subject: Diagnostic procedure
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Aim: To facilitate the transition from Assistant Practitioner (AP) to Radiographer Objectives: Identify and address learning needs of AP's to enable progression to eligibility for state registration with the Health & Care Professions Council. Design...
Additional file 3 of Modifiable factors associated with postoperative atrial fibrillation in older patients with hip fracture in an orthogeriatric care pathway: a nested case–control study
Creators: name: Gay, Pierre
name: Genet, Bastien
name: Rouet, Audrey
name: Alkouri, Rana
name: Cohen-Bittan, Judith
name: Boddaert, Jacques
name: Zerah, Lorène
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Comparison between included and excluded patients in the perioperative geriatric unit.
Selective 5-Hydroxytryptamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine: Identification of Drugs with Antidepressant-Like Action
Creators: name: Jensen, Niels H.
name: Kozikowski, Alan P.
name: Roth, Bryan L.
name: Malberg, Jessica E.
name: Manzano, Michael L.
name: Caldarone, Barbara
name: Kadari, Sudhakar
name: Kurome, Toru
name: Cho, Sung Jin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine (9), which itself was discovered as a lead compound in a high-throughput screening campaign. Starting from 9, which shows modest activity as a 5-HT2C agonist, a series of 1-aminomethyl-2-phenylcyclopropanes was investigated as 5-HT2C agonists through iterative structural modifications. Key pharmacophore feature of this new class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted benzene ring. Among the tested compounds, several were potent and efficacious 5-HT2C receptor agonists with selectivity over both 5-HT2A and 5-HT2B receptors in functional assays. The most promising compound is 37 with 120- and 14-fold selectivity over 5-HT2A and 5-HT2B, respectively (EC50 = 585, 65, and 4.8 nM at the 2A, 2B, and 2C subtypes, respectively). In animal studies, compound 37 (10–60 mg/kg) decreased immobility time in the mouse forced swim test.
On the Origin of Pluto's Small Satellites by Resonant Transport
Creators: name: Cheng, W. H.
name: Peale, S. J.
name: Lee, Man Hoi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The orbits of Pluto's four small satellites (Styx, Nix, Kerberos, and Hydra) are nearly circular and coplanar with the orbit of the large satellite Charon, with orbital periods nearly in the ratios 3:1, 4:1, 5:1, and 6:1 with Charon's orbital period. These properties suggest that the small satellites were created during the same impact event that placed Charon in orbit and had been pushed to their current positions by being locked in mean-motion resonances with Charon as Charon's orbit was expanded by tidal interactions with Pluto. Using the Pluto-Charon tidal evolution models developed by Cheng et al. (2014), we show that stable capture and transport of a test particle in multiple resonances at the same mean-motion commensurability is possible at the 5:1, 6:1, and 7:1 commensurabilities, if Pluto's zonal harmonic $J_{2P} = 0$. However, the test particle has significant orbital eccentricity at the end of the tidal evolution of Pluto-Charon in almost all cases, and there are no stable captures and transports at the 3:1 and 4:1 commensurabilities. Furthermore, a non-zero hydrostatic value of $J_{2P}$ destroys the conditions necessary for multiple resonance migration. Simulations with finite but minimal masses of Nix and Hydra also fail to yield any survivors. We conclude that the placing of the small satellites at their current orbital positions by resonant transport is extremely unlikely.
description: 22 pages, including 7 figures; accepted for publication in Icarus
Empirical ugri-UBVRc Transformations for Galaxies
Creators: name: Cook, David O.
name: Dale, Daniel A.
name: Johnson, Benjamin D.
name: Van Zee, Liese
name: Lee, Janice C.
name: Kennicutt, Robert C.
name: Calzetti, Daniela
name: Staudaher, Shawn M.
name: Engelbracht, Charles W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present empirical color transformations between Sloan Digital Sky Survey ugri and Johnson-Cousins UBVRc photometry for nearby galaxies (D < 11 Mpc). We use the Local Volume Legacy (LVL) galaxy sample where there are 90 galaxies with overlapping observational coverage for these two filter sets. The LVL galaxy sample consists of normal, non-starbursting galaxies. We also examine how well the LVL galaxy colors are described by previous transformations derived from standard calibration stars and model-based galaxy templates. We find significant galaxy color scatter around most of the previous transformation relationships. In addition, the previous transformations show systematic offsets between transformed and observed galaxy colors which are visible in observed color-color trends. The LVL-based $galaxy$ transformations show no systematic color offsets and reproduce the observed color-color galaxy trends.
description: Accepted for publication in MNRAS (9 pages, 6 figures, 4 tables)
title: Postmortem stereotactic-guided biopsies in minimally invasive autopsy
Creators: name: Koning, Anton
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Biopsy
subject: CT
subject: Interventional non-vascular
subject: Economics
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: CT-guided biopsies require validation scans that take up a large part of the procedure time. Postmortem stereotactic-guided biopsies of the torso could alleviate this drawback by making validation scans...
Strumenti d’incentivo e modelli di gestione del personale volontario nelle organizzazioni non profit
Creators: name: Amendola, Adalgiso
name: Troisi, Roberta
Publisher: name: Universita' degli Studi di Salerno
Year: 2004

description: Questo lavoro prova ad offrire soluzioni ai problemi legati alla complessa gestione dei volontari nel mondo non profit, considerando il ciclo di vita del lavoratore volontario, dalla selezione alla definizione del ruolo e della mansione ai meccanismi d’incentivo e di valutazione.Il modello d’agente utilizzato, riconducibile al lavoratore volontario è quello del “non egoista per simpatia”. È inoltre scopo di questo lavoro considerare le conseguenze, in termini di soluzioni organizzative, derivanti da una corretta gestione di tali risorse umane.
HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL - Unidad de Evaluación de Tecnologías Sanitarias
Creators: name: Santafe, Angie
name: Comas, David
name: Rojas- Reyes, María
name: Rispau, Ariadna
name: Alonso-Coello, Pablo
name: Rada, Gabriel
name: Urrutia, Gerard
name: Plana, Nieves
name: Zamora, Javier
name: Correa-Pérez, Andrea
name: Gil, Andrea
name: Jimenez, Juan
name: González, Raquel
name: Ávila, Camila
name: Verdugo, Francisca
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: capacity building
subject: Continuos update
subject: Epistemonikos L.OVE Platform
subject: Evidence-based medicine
subject: Evidence Synthesis
subject: Inform Health Decisions
subject: knowledge transfer
subject: Living Evidence

description: Comunication
Anti-AIDS Agents 81. Design, Synthesis, and Structure−Activity Relationship Study of Betulinic Acid and Moronic Acid Derivatives as Potent HIV Maturation Inhibitors †
Creators: name: Huang, Li
name: Chen, Chin-Ho
name: Lee, Kuo-Hsiung
name: Qian, Keduo
name: Kuo, Reen-Yun
name: Morris-Natschke, Susan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl- betulinic acid (MSB) analogs were also designed to better understand the contribution of the C-3′ dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical trials. In addition, another triterpene skeleton, moronic acid (MA, 3) was also employed to study the influence of the backbone and the C-3 modification towards the anti-HIV activity of this compound class. This study enabled us to better understand the structure-activity relationships (SAR) of triterpene-derived anti-HIV agents, and led to the design and synthesis of compound 12 (EC50: 0.0006 μM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor.
title: Radiological findings of lesions among victims of terroristic attack in St. Petersburg
Creators: name: Drozdov, Aleksandr
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Bones
subject: Emergency
subject: Trauma
subject: CT
subject: CT-Angiography
subject: Education
subject: Acute
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: • To understand and explain the basic injuring mechanisms of the bomb implemented during the terroristic attack in the subway at St. Petersburg, Russia on April 3, 2017 • To illustrate and describe series of the Multidetector computed tomography...
Additional file 4 of Modifiable factors associated with postoperative atrial fibrillation in older patients with hip fracture in an orthogeriatric care pathway: a nested case–control study
Creators: name: Gay, Pierre
name: Genet, Bastien
name: Rouet, Audrey
name: Alkouri, Rana
name: Cohen-Bittan, Judith
name: Boddaert, Jacques
name: Zerah, Lorène
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4. Cardiovascular drugs before surgery at baseline in patients hospitalized in the perioperative geriatric unit with and without post-operative atrial fibrillation (POAF).
Antitumor Agents 286. Design, Synthesis, and Structure−Activity Relationships of 3′ R ,4′ R -Disubstituted-2′,2′-dimethyldihydropyrano[2,3- f ]chromone (DSP) Analogues as Potent Chemosensitizers to Overcome Multidrug Resistance
Creators: name: Shi, Qian
name: Bastow, Kenneth F.
name: Lee, Kuo-Hsiung
name: Zhou, Ting
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In this study, various 3′R,4′R-disubstituted-2′,2′-dimethydihydropyrano[2,3-f]chromone (DSP) derivatives were discovered as potent chemosensitizers in the treatment of multidrug resistant cancer cells. Twenty-four DSP analogs (5–28) were synthesized and evaluated against a multi-drug resistant (MDR) cell line (KB-Vin) with and without vincristine (VCR). All DSP analogs exhibited low intrinsic cytotoxicity. However, in combination treatment, most DSPs reversed resistance to VCR and lowered the GI50 value of VCR by 12–349-fold. At a concentration of 1μg/mL, three compounds, 11, 14 and 21, fully reversed resistance to VCR in KB-Vin cancer cells, a twofold increase compared to verapamil, a first generation chemosensitizer. Detailed structure-activity relationship (SAR) conclusions were established based on 3′ and 4′ substitutions. Moreover, a preliminary mechanism study indicated that the chemosensitizing activity of DSP analogs results from inhibition of P-glycoprotein (P-gp) over-expressed in MDR cancer cells.1
title: Straight to test CTC for investigation of symptomatic lower GI symptoms in the English, two week wait referral system
Creators: name: Hudson, Sarah
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Colon
subject: Gastrointestinal tract
subject: Abdomen
subject: Colonography CT
subject: CT-Colonography

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Colorectal cancer is a common malignancy; it is the second commonest cause of cancer related mortality in Europe and colonoscopy services are increasingly under strain due to enhanced population screening programmes [1, 2]. Straight to test (STT)...
title: Is MRI the gold standard imaging technique to diagnose levator ani muscle avulsion?
Creators: name: Stankiewicz, Aleksandra
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Genital / Reproductive system female
subject: Anatomy
subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: MR
subject: Ultrasound
subject: Computer Applications-3D
subject: Imaging sequences
subject: Obstetrics
subject: Pelvic floor dysfunction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The levator ani muscle (LAM) is a broad muscular sheet of variable thickness attached to the internal surface of the bony pelvis. There is significant controversy about the sub-divisions of the muscle, however, it is broadly accepted that it is...
Observations of Subarcsecond Bright Dots in the Transition Region above Sunspots with the Interface Region Imaging Spectrograph
Creators: name: Tian, H.
name: Kleint, L.
name: Peter, H.
name: Weber, M.
name: Testa, P.
name: DeLuca, E.
name: Golub, L.
name: Schanche, N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Observations with the Interface Region Imaging Spectrograph (IRIS) have revealed numerous sub-arcsecond bright dots in the transition region above sunspots. These bright dots are seen in the 1400Å and 1330Å slit-jaw images. They are clearly present in all sunspots we investigated, mostly in the penumbrae, but also occasionally in some umbrae and light bridges. The bright dots in the penumbrae typically appear slightly elongated, with the two dimensions being 300--600 km and 250--450 km, respectively. The long sides of these dots are often nearly parallel to the bright filamentary structures in the penumbrae but sometimes clearly deviate from the radial direction. Their lifetimes are mostly less than one minute, although some dots last for a few minutes or even longer. Their intensities are often a few times stronger than the intensities of the surrounding environment in the slit-jaw images. About half of the bright dots show apparent movement with speeds of $\sim$10--40~km~s$^{-1}$ in the radial direction. Spectra of a few bright dots were obtained and the Si~{\sc{iv}}~1402.77Å line profiles in these dots are significantly broadened. The line intensity can be enhanced by one to two orders of magnitude. Some relatively bright and long-lasting dots are also observed in several passbands of the Atmospheric Imaging Assembly onboard the Solar Dynamics Observatory, and they appear to be located at the bases of loop-like structures. Many of these bright dots are likely associated with small-scale energy release events at the transition region footpoints of magnetic loops.
description: 5 figures, will appear in ApJL
title: A pictorial review of peripheral vascular malformations and the use of Onyx in their treatment.
Creators: name: Kok, Shawn
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Arteriovenous malformations
subject: Embolisation
subject: Ultrasound-Power Doppler
subject: Ultrasound-Colour Doppler
subject: MR
subject: Vascular
subject: Interventional vascular
subject: Extremities

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To review the imaging features of peripherally located vascular malformations on both ultrasound and MRI. 2. To illustrate the use of Onyx ,an ethylene-vinyl alcohol copolymer liquid embolic agent as a treatment...
Additional file 5 of Modifiable factors associated with postoperative atrial fibrillation in older patients with hip fracture in an orthogeriatric care pathway: a nested case–control study
Creators: name: Gay, Pierre
name: Genet, Bastien
name: Rouet, Audrey
name: Alkouri, Rana
name: Cohen-Bittan, Judith
name: Boddaert, Jacques
name: Zerah, Lorène
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5. Sensitivity analysis: exclusion of patient with pre-existing atrial fibrillation prior to surgery.
Antitumor Agents. 272. Structure−Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues
Creators: name: Bastow, Kenneth F.
name: Hung, Mien-Chie
name: Peng, Chieh-Yu
name: Dong, Yizhou
name: Teng, Che-Ming
name: Yu, Donglei
name: Shi, Qian
name: Wu, Pei-Chi
name: Pan, Shiow-Lin
name: Lee, Eva Y.-H. P.
name: Liu, Yi-Nan
name: Nakagawa-Goto, Kyoko
name: Brossi, Arnold
name: Hsu, Jennifer L.
name: Pai, Huei-Chen
name: Morris-Natschke, Susan L.
name: Lang, Jing-Yu
name: Lee, Kuo-Hsiung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Neo-tanshinlactone (1) and its previously reported analogs, such as 2, are potent and selective in vitro anti-breast cancer agents. The synthetic pathway to 2 was optimized from seven to five steps, with a better overall yield. Structure–activity relationships studies on these compounds revealed some key molecular determinants for this family of anti-breast agents. Several derivatives (19-21 and 24) exerted potent and selective anti-breast cancer activity with IC50 values of 0.3, 0.2, 0.1 and 0.1 μg/mL, respectively, against the ZR-75-1 cell lines. Compound 24 was two- to three-fold more potent than 1 against SK-BR-3 and ZR-75-1. Importantly, 21 exhibited high selectivity; it was 23 times more active against ZR-75-1 than MCF-7. Compound 20 had an approximately 12-fold ratio of SK-BR-3/MCF-7 selectivity. In addition, analog 2 showed potent activity against a ZR-75-1 xenograft model, but not PC-3 and MDA-MB-231 xenografts, as well as high selectivity against breast cancer cell line compared with normal breast tissue-derived cell lines. Further development of lead compounds 19-21 and 24 as clinical trial candidates is warranted.
Photon-Dominated Region Modeling of the [C I],[C II], and CO Line Emission from a Boundary in the Taurus Molecular Cloud
Creators: name: Orr, Matthew
name: Pineda, Jorge
name: Goldsmith, Paul
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present [Ci] and [Cii] observations of a linear edge region in the Taurus molecular cloud, and model this region as a cylindrically symmetric PDR exposed to a low-intensity UV radiation field. The sharp, long profile of the linear edge makes it an ideal case to test PDR models and determine cloud parameters. We compare observations of the [C i], 3P1 -> 3P0 (492 GHz), [C i] 3P2 -> 3P1 (809 GHz), and [Cii] 2P3/2 -> 2P1/2 (1900 GHz) transitions, as well as the lowest rotational transitions of 12CO and 13CO, with line intensities produced by the RATRAN radiative transfer code from the results of the Meudon PDR code. We constrain the density structure of the cloud by fitting a cylindrical density function to visual extinction data. We study the effects of variation of the FUV field, 12C/13C isotopic abundance ratio, sulfur depletion, cosmic ray ionization rate, and inclination of the filament relative to the sky-plane on the chemical network of the PDR model and resulting line emission. We also consider the role of suprathermal chemistry and density inhomogeneities. We find good agreement between the model and observations, and that the integrated line intensities can be explained by a PDR model with an external FUV field of 0.05 G0, a low ratio of 12C to 13C ~ 43, a highly depleted sulfur abundance (by a factor of at least 50), a cosmic ray ionization rate (3 - 6) x 10-17 s^-1, and without significant effects from inclination, clumping or suprathermal chemistry.
description: Accepted for publication in the Astrophysical Journal (Sept. 1, 2014), 11 pages, 7 figures
title: Diagnosis of Neurological Diseases Associated with Alcohol Consumption
Creators: name: de Grazia, Jose
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: CT
subject: Education
subject: Cirrhosis
subject: Dementia
subject: Metabolic disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To know the main diseases of the central nervous system (CNS) associated with alcohol consumption, and to identify its classical neuroimaging patterns. To keep in mind a simple neuroradiological approach algorithm for these...
Additional file 1 of High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials
Creators: name: Ovtcharenko, N.
name: Ho, E.
name: Alhazzani, W.
name: Cortegiani, A.
name: Ergan, B.
name: Scala, R.
name: Sotgiu, G.
name: Chaudhuri, D.
name: Oczkowski, S.
name: Lewis, K.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1: Table S1. Embase and Medline Search Results. Table S2. Cochrane Central Search Results. Table S3. Excluded Studies. Table S4. Risk of Bias Table. Fig. S1. Forest plot of mortality—subgroup analysis by risk of bias. Fig. S2. Forest plot of mortality—subgroup analysis excluding Wang et al. Fig. S3. Forest plot of intubation—subgroup analysis by risk of bias. Fig. S4. Forest plot of intubation—subgroup analysis excluding Wang et al. Fig. S5. Forest plot of ICU Length of Stay—subgroup analysis by risk of bias. Fig. S6. Forest plot of ICU Length of Stay—subgroup analysis excluding Wang et al. Fig. S7. Forest plot of Hospital Length of Stay—subgroup analysis by risk of bias. Fig. S8. Forest plot of change in comfort—subgroup analysis by AECOPD studies alone. Fig. S9. Forest plot of change in dyspnea—subgroup analysis by AECOPD studies alone. Fig. S10. Forest plot of change in respiratory rate—subgroup analysis by AECOPD studies alone. Fig. S11. Forest plot of respiratory rate—subgroup analysis by risk of bias. Fig. S12. Forest plot of change in PO2. Fig. S13. Forest plot of change in PO2—subgroup analysis by risk of bias. Fig. S14. Forest plot of change in PCO2. Fig. S15. Forest plot of change in PCO2—subgroup analysis by AECOPD studies alone. Fig. S16. Forest plot of change in PCO2—subgroup analysis by risk of bias. Fig. S17. Trial sequential analysis for mortality. Fig. S18. Trial sequential analysis for intubation. Fig. S19. Trial sequential analysis for ICU length of stay.
Antitumor Agents. 280. Multidrug Resistance-Selective Desmosdumotin B Analogues
Creators: name: Chen, Tzu-Hsuan
name: Bastow, Kenneth F.
name: Nakagawa-Goto, Kyoko
name: Hung, Hsin-Yi
name: Sedykh, Alexander
name: Lai, Chin-Yu
name: Lee, Kuo-Hsiung
name: Chang, Po-Cheng
name: Zhu, Hao
name: Wu, Pei-Chi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: 6,6,8-Triethyldesmosdumotin B (2) was discovered as a MDR–selective flavonoid with significant in vitro anticancer activity against a multi-drug resistant (MDR) cell line (KB-VIN) but without activity against the parent cells (KB). Additional 2-analogues were synthesized and evaluated to determine the effect of B-ring modifications on MDR-selectivity. Analogues with a B-ring Me (3) or Et (4) group had substantially increased MDR–selectivity. Three new disubstituted analogues, 35, 37 and 49, also had high collateral sensitivity (CS) indices of 273, 250 and 100, respectively. Furthermore, 2–4 also displayed MDR-selectivity in an MDR hepatoma-cell system. While 2–4 showed either no or very weak inhibition of cellular P-glycoprotein (P-gp) activity, they either activated or inhibited the actions of the first generation P-gp inhibitors verapamil or cyclosporin, respectively.
Coronal loops above an Active Region - observation versus model
Creators: name: Bourdin, Philippe-A.
name: Bingert, Sven
name: Peter, Hardi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We conducted a high-resolution numerical simulation of the solar corona above a stable active region. The aim is to test the field-line braiding mechanism for a sufficient coronal energy input. We also check the applicability of scaling laws for coronal loop properties like the temperature and density. Our 3D-MHD model is driven from below by Hinode observations of the photosphere, in particular a high-cadence time series of line-of-sight magnetograms and horizontal velocities derived from the magnetograms. This driving applies stress to the magnetic field and thereby delivers magnetic energy into the corona, where currents are induced that heat the coronal plasma by Ohmic dissipation. We compute synthetic coronal emission that we directly compare to coronal observations of the same active region taken by Hinode. In the model, coronal loops form at the same places as they are found in coronal observations. Even the shapes of the synthetic loops in 3D space match those found from a stereoscopic reconstruction based on STEREO spacecraft data. Some loops turn out to be slightly over-dense in the model, as expected from observations. This shows that the spatial and temporal distribution of the Ohmic heating produces the structure and dynamics of a coronal loops system close to what is found in observations.
description: 7 pages, 7 figures, special issue
title: Improving patient experience through ongoing feedback
Creators: name: Bowie, Rachael
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Workforce
subject: Outcomes
subject: Education
subject: Audit and standards
subject: PET-CT
subject: MR
subject: CT
subject: Radiographers

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The importance of patient experience feedback as a means of informing NHS care in the United Kingdom (UK) has been widely documented [1]. Since Lord Darzi’s report ‘high quality care for all’ [2], processes have been put in place to ensure...
Status of the KM3NeT project
Creators: name: Margiotta, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: KM3NeT is a deep-sea research infrastructure being constructed in the Mediterranean Sea. It will be installed at three sites: KM3NeT-Fr, offshore Toulon, France, KM3NeT-It, offshore Portopalo di Capo Passero, Sicily (Italy) and KM3NeT-Gr, offshore Pylos, Peloponnese, Greece. It will host the next generation Cherenkov neutrino telescope and nodes for a deep sea multidisciplinary observatory, providing oceanographers, marine biologists, and geophysicists with real time measurements. The neutrino telescope will search for Galactic and extra-Galactic sources of neutrinos, complementing IceCube in its field of view. The detector will have a modular structure and consists of six building blocks, each including about one hundred Detection Units (DUs). Each DU will be equipped with 18 multi-PMT digital optical modules. The first phase of construction has started and shore and deep-sea infrastructures hosting the future KM3NeT detector are being prepared in France near Toulon and in Italy, near Capo Passero in Sicily. The technological solutions for KM3NeT and the expected performance of the detector are presented and discussed.
description: 12 pages, 9 figures, talk given at the 13th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD13), 7-10 Oct 2013, Siena, Italy (http://www.dsfta.unisi.it/it/eventi/13th-topical-seminar-innovative-particle-and-radiation-detectors-iprd13)
title: Mammography and mammoscintigraphy with 99mTc-MIBI in diagnostic of multicentric breast cancer
Creators: name: Petrova, Anna
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: Mammography
subject: Nuclear medicine conventional
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The development of effective diagnostic methods in multicentric breast cancer (BC) is important in clinical practice, because of its influence on further surgical and radiation therapy. Unlike ordinary breast cancer, multicentric form is a special...
title: The Committee and the Uncommitted : Material Assistance to Members in Need at a Pentecostal Church in Western Kenya
Creators: name: Kroeker, Lena
name: Gez, Yonatan N.
name: Bayreuth Academy Of Advanced African Studies
Publisher: name: University of Bayreuth
Year: 2022
Subjects: subject: Kenya
subject: Social Support
subject: Solidarity
subject: Pentecostalism
subject: Anthropology
subject: FOS: Sociology
subject: 200
subject: 300
subject: 360
subject: 390
subject: 960

description: In Kenya today, churches serve as a central pillar of socio-economic support to people in their hour of need. Drawing on ethnographic research at a small Pentecostal church in Kisumu, Western Kenya, we present four modes of such material support. This classification allows us to examine the provision of church assistance as a subtle balancing act in which leaders and so-called ‘super-members’ seek to bind lay members into greater commitment by projecting institutional dependability while carefully avoiding excessive demands. Rejecting the caricature of the self-enriching charismatic leader, and focused on the intertwinement of religious commitment and class, we offer a fresh examination of churches’ mechanisms of welfare assistance beyond a simple vertical/horizontal (or institutional/congregational) binarism.