cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
E02634: John Chrysostom delivers an encomium On the Holy Martyrs during a festival held after Pentecost for a group of martyrs who were burned on an iron ladder/grill. Written in Greek at Antioch (Syria) or Constantinople, 386/407.
Creators: name: Erizos
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: John Chrysostom, On the Holy Martyrs (CPG 4365, BHG 1188)

Summary

1. This is a festival for a group of martyrs, which follows less than seven days after Pentecost. The martyrs do not differ from angels, except by name, since both of them are immortal and live in heaven. Their works are the same. If there is something good about the existence of death, it is that it has given us the possibility of martyrdom. God has turned the doom of humanity, caused by the Devil through death, into a blessing. These martyrs resemble a dancing party by their joyful haste towards martyrdom, and a military squadron by the bravery of their perseverance. Their martyrdom resembles a war of two camps fighting one another, as the martyrs enter the contest with their bare bodies, and the tyrants with their weapons. With their hands bound, the martyrs are beaten and skinned from all sides. Next, they are bound on a stake and suffer more torments, and, after that, they are placed on an iron ladder (klimax) and roasted over burning coals.

2. This ladder should remind us of Jacob’s ladder, though here we have martyrs instead of angels. Martyrdom is an exemplar of perseverance for us common people, who are unable to bear even a simple fever. The angels marvel at the blood flowing from the bodies of the martyrs, while the demons are horrified. The martyrdoms of the saints are the natural sequel to the death of Christ. What follows is the even more wondrous condition of the heavenly life prepared by God for those who love him, and no one loves him more than the martyrs. The angels welcome them with admiration, just like people admire foreign athletes when they visit their towns. They venerate God, and are treated by Him as friends, not servants. We must yearn for martyrdom and prepare ourselves for it, by fighting our own passions.

3. The method of achieving this is by looking at the rewards that follow, rather than the suffering involved in, actions like charity, fasting, and vigils. When lying in our beds, we should keep in mind the iron ladder of the martyrs. We should adorn the walls of our heart with the pictures of the saints’ martyrdom, just like people adorn their houses with paintings of flowers.
Efficient separation of coal gasification fine slag from Texaco gasifier and microstructures and elemental characteristics of separated components
Creators: name: Xiong, Shanxin
name: Yang, Nana
name: Lv, Fengyan
name: Zhang, Yukun
name: Zhang, Wei
name: Wang, Xiaoqin
name: Chu, Jia
name: Li, Zhen
name: Wang, Hong
name: Xu, Jianwei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Coal gasification fine slag (CGFS) is one of the by-products of coal gasification process, which is mainly composed of inorganic minerals and residual carbon. The key to realize the high-value utilization of CGFS is separating the residual carbon and mineral in CGS effectively. Owing to irregular distribution of carbon in different size of CGFS, which could not be enriched by simple grinding and screening for component enrichment. In this paper, the enrichment of CGFS was carried out by the float-sink method, which is low-cost and does not result in the loss of raw materials. The carbon-rich particles (CRP, ash: 27.89%) and mineral-rich particles (MRP, ash: 78.01%) were obtained, where CRP contains a large amount of amorphous carbon with rich porous structure, while MRP is a heterogeneous material containing not only inorganic minerals but also organic carbon with low porosity. The mineral particles exist as aluminosilicates with a high degree of polymerization. The results of this paper will provide theoretical and technical support for the high-value utilization of CGFS.
sj-pdf-1-hpq-10.1177_1359105320982042 – Supplemental material for Depression symptoms, HIV testing, linkage to ART, and viral suppression among women in a high HIV burden district in KwaZulu-Natal, South Africa: A cross-sectional household study
Creators: name: Kaymarlin Govender
name: Durevall, Dick
name: Cowden, Richard G
name: Beckett, Sean
name: Kharsany, Ayesha BM
name: Lewis, Lara
name: George, Gavin
name: Cawood, Cherie
name: Khanyile, David
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-hpq-10.1177_1359105320982042 for Depression symptoms, HIV testing, linkage to ART, and viral suppression among women in a high HIV burden district in KwaZulu-Natal, South Africa: A cross-sectional household study by Kaymarlin Govender, Dick Durevall, Richard G Cowden, Sean Beckett, Ayesha BM Kharsany, Lara Lewis, Gavin George, Cherie Cawood and David Khanyile in Journal of Health Psychology
E02635: Gregory of Tours, in his Glory of the Confessors (45), describes how *Romanus (priest of Blaye, ob. late 4th c., S01129) from his grave at Blaye (near Bordeaux, south-west Gaul) protected people travelling on the river Garonne from shipwreck; Gregory himself witnessed the calming of a storm and flood. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 45

Habetur in hoc terreturio et sanctus Romanus presbiter, quem, ut scripta vitae eius edocent, Martinus eum noster sepulturae locavit. Est autem sepulchrum eius contiguum Blaviensi castello super litus amnis Garonnae. In quo saepe naufragio perituros virtutis suae salvat occursu, proclamantibus inter fluctus torrentis undosi: 'Miserere nostri, sanctae Romane confessor Dei'. Sed mox sedata tempestate, obtata litora potiuntur. Nec fas est tamen ullum perire naufragio, qui eius basilicam amnis de medio contemplare meruerit. Quod et nos valde in grandi necessitate experti sumus. Nam cum imber creberrimus per multos defluens dies amnem Garonnam extra litora eiecisset, atque, inpellente vento, validis fluetibus exundaret, elevarenturque fluctuum montes validii, qui non parvum intuentibus ingererent metum, exoratos beatus confessor obtenuit, sicut credimus, virtutis suae suffragio, ut, conpressis fragoribus, planum praeberetur fluminis alveum. Et sic ingressi navem, ripae alteri sine periculo sumus devecti.

'In this territory [of Bordeaux] is [the tomb of] Saint Romanus the priest. According to the written records of his life, our Martin [of Tours] placed him in his tomb. For his tomb is next to the fortress of Blaye, which is situated on a bank of the Garonne River. Often through the display of his power he rescues people who are about to die from being shipwrecked in this river, when they cry out amidst the waves and currents of the torrent: ‘Have pity on us, Saint Romanus, confessor of God.’ Soon the storm is quieted, and the people reach the banks they had hoped for. It is not proper for anyone who has deserved to see Romanus’ church from the middle of the river to die in a shipwreck. I myself experienced his power in a situation of great duress. A driving storm that rained for many days caused the Garonne river to flood outside its banks. As the wind whipped about, the river overflowed in huge waves. Overpowering mountains of water were tossed up that caused great fear among the onlookers. But after the blessed confessor was petitioned, by the assistance of his power he brought it about (so I believe) that he restrained the crashing and caused the channel of the river to be level. And so I entered a boat and crossed to the other bank without any danger.'

Text: Krusch 1969, 325-326. Translation: Van Dam 2004, 36, lightly modified.
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration
Creators: name: Liu, Sheng
name: Hu, Yiqiang
name: Xu, Weihua
name: Liu, Weijian
name: Wang, Bingjin
name: Zeng, Xianlin
name: Shao, Zengwu
name: Yang, Cao
name: Xiong, Liming
name: Cai, Xianyi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Intervertebral disc degeneration (IVDD) is a leading cause of low back pain that incurs large socioeconomic burdens. Growing evidence reveals that macroautophagy/autophagy dysregulation contributes to IVDD, but the exact role of autophagy and its regulatory mechanisms remain largely unknown. Here, we found that mechanical overloading impaired the autophagic flux of nucleus pulposus (NP) cells in vivo and in vitro. Mechanistically, the impairment of autophagic flux was attributed to lysosomal dysfunction induced by overloading. Overloading could also lead to lysosomal membrane permeabilization and consequent lysosome-dependent cell death. As critical effectors of lysosomal quality control pathways, CHMP4B (charged multivesicular body protein 4B) and TFEB (transcription factor EB) were downregulated in overloading-treated NP cells and degenerative discs. Restoring lysosomal function by CHMP4B or TFEB overexpression attenuated autophagic flux impairment of NP cells and protected against overloading-induced IVDD. Additionally, human IVDD was associated with impaired autophagy, and defective lysosomal quality control was also linked to human IVDD. Collectively, these findings highlighted that lysosomal defects were crucial for mechanical overloading-induced autophagic flux impairment and death of NP cells, suggesting the potential therapeutic relevance of restoring lysosomal function for IVDD. Abbreviations: ADAMTS4: ADAM metallopeptidase with thrombospondin type 1 motif 4; Ad: adenovirus; AO: acridine orange; BafA1: bafilomycin A1; CHMP4B: charged multivesicular body protein 4B; CTSD: cathepsin D; CV%: coefficient of variation; DMSO: dimethyl sulfoxide; ESCRT: endosomal sorting complex required for transport; HE: haemotoxylin and eosin; IVDD: intervertebral disc degeneration; LAMP: lysosomal associated membrane protein; LMP: lysosomal membrane permeabilization; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MFI: mean fluorescence intensity; MMP3: matrix metallopeptidase 3; MRI: magnetic resonance imaging; NP: nucleus pulposus; PG: Pfirrmann grade; PI: propidium iodide; RT-qPCR: reverse transcription-quantitative PCR; SOFG: safranin O fast green; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; TFEB: transcription factor EB.
Die Enzyklika "Laudato si'" von Papst Franziskus. Auch ein Beitrag zur Problematik des Klimawandels und zur Ethik der Energiewende
Creators: name: Heimbach-Steins, Marianne
name: Lienkamp, Andreas
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2015
Subjects: Energie; Wende; Soziallehre; Papst; Franziskus; Laudato si; LS; Energie; Ethik; Ökologie; Gerechtigkeit; Umwelt; Engagement; Gesellschaft; Klima; Praxis; Verantwortung; Kirche; Verkündigung

description: Zusammenfassung
Die Enzyklika Laudato si’ formuliert zentrale politische und moralische Herausforderungen und legt die christlichen Grundlagen einer „ganzheitlichen Ökologie“ dar. Dazu gehört, dass der Einsatz für den Schutz der Natur eine prioritäre Gerechtigkeitsfrage ist, dass Umwelt- und Sozialengagement zusammengehen müssen und dass die Option für die Armen dementsprechend eine Option für die Schöpfung umfassen muss (und umgekehrt). Damit bietet die Enzyklika eine grundsätzliche Orientierung zur sozialen und ökologischen Verantwortung, die zugleich konkrete politisch-praktische Provokationen und Impulse enthält. Der Beitrag ordnet die Enzyklika in die Tradition der Sozialverkündigung ein, stellt wesentliche Aspekte ihrer theologisch-ethischen und spirituellen Fundamente im Überblick vor, analysiert die Aussagen zur Klimaproblematik und zur Energie-Ethik und greift einige Aspekte auf, die vertiefter Diskussion bedürfen.

Abstract
The encyclical Laudato si’ formulates crucial political and moral challenges and explains the Christian foundations of the „integral ecology“. This includes the effort to protect the nature as a priority issue of justice, the correlation of ecological and social commitment and the interdependence of the option for the poor and an option for the creation. The encyclical gives a fundamental orientation to social and ecological responsibility, likewise comprising concrete political and practical provocations and stimuli. The paper situates the encyclical within the tradition of Catholic social teaching, and outlines the essential aspects of the theological-ethical and spiritual basis included in the encyclical. Furthermore the article analyses the statements on climate problems as well as on energy ethics and describes some aspects that require a deepened discussion.
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 56 (2015): Ethische Herausforderungen der Energiewende
Demokratie und Partizipation im 21. Jahrhundert. Bericht über das 25. Forum Sozialethik 2015 in der Katholischen Akademie Die Wolfsburg
Creators: name: Zink, Sebastian
name: Wahl, Stefanie A.
name: Henkel, Christian
name: Fischer, Luisa
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2016
Subjects: Demokratie; Partizipation; Herausforderung; Versprechen; Repräsentation; Zukunft; Sozialethik; Forum

description: Bericht über das 25. Forum Sozialethik 2015 in der Katholischen Akademie Die Wolfsburg
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 57 (2016): Sozialethik der Pflege und Pflegepolitik
Supplemental Material, sj-docx-2-cpa-10.1177_0706743720984679 - How High? Trends in Cannabis Use Prior to First Admission to Inpatient Psychiatry in Ontario, Canada, between 2007 and 2017: À quelle hauteur? Les tendances de l’usage du cannabis avant la première hospitalisation en psychiatrie en Ontario, Canada entre 2007 et 2017
Creators: name: McGuckin, Taylor
name: Ferro, Mark A.
name: Hammond, David
name: Stewart, Shannon
name: Maloney-Hall, Bridget
name: Nawaf Madi
name: Porath, Amy
name: Perlman, Christopher M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental Material, sj-docx-2-cpa-10.1177_0706743720984679 for How High? Trends in Cannabis Use Prior to First Admission to Inpatient Psychiatry in Ontario, Canada, between 2007 and 2017: À quelle hauteur? Les tendances de l’usage du cannabis avant la première hospitalisation en psychiatrie en Ontario, Canada entre 2007 et 2017 by Taylor McGuckin, Mark A. Ferro, David Hammond, Shannon Stewart, Bridget Maloney-Hall, Nawaf Madi, Amy Porath and Christopher M. Perlman in The Canadian Journal of Psychiatry
Development and validation of a sensitive sandwich ELISA against human PINK1
Creators: name: Baninameh, Zahra
name: Watzlawik, Jens O.
name: Bustillos, Bernardo A.
name: Fiorino, Gabriella
name: Yan, Tingxiang
name: Lewicki, Szymon L.
name: Zhang, Haonan
name: Dickson, Dennis W.
name: Siuda, Joanna
name: Wszolek, Zbigniew K.
name: Springer, Wolfdieter
name: Fiesel, Fabienne C.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Developmental Biology

description: The ubiquitin kinase and ligase PINK1 and PRKN together label damaged mitochondria for their elimination in lysosomes by selective autophagy (mitophagy). This cytoprotective quality control pathway is genetically linked to familial Parkinson disease but is also altered during aging and in other neurodegenerative disorders. However, the molecular mechanisms of these mitophagy changes remain uncertain. In healthy mitochondria, PINK1 protein is continuously imported, cleaved, and degraded, but swiftly accumulates on damaged mitochondria, where it triggers the activation of the mitophagy pathway by phosphorylating its substrates ubiquitin and PRKN. Levels of PINK1 protein can therefore be used as a proxy for mitochondrial damage and mitophagy initiation. However, validated methodologies to sensitively detect and quantify PINK1 protein are currently not available. Here, we describe the development and thorough validation of a novel immunoassay to measure human PINK1 on the Meso Scale Discovery platform. The final assay showed excellent linearity, parallelism, and sensitivity. Even in the absence of mitochondrial stress (i.e. at basal conditions), when PINK1 protein is usually not detectable by immunoblotting, significant differences were obtained when comparing samples from patient fibroblasts or differentiated neurons with and without PINK1 expression. Of note, PINK1 protein levels were found increased in human postmortem brain with normal aging, but not in brains with Alzheimer disease, suggesting that indeed different molecular mechanisms are at play. In summary, we have developed a novel sensitive PINK1 immunoassay that will complement other efforts to decipher the roles and biomarker potential of the PINK1-PRKN mitophagy pathway in the physiological and pathological context. Abbreviations: AD: Alzheimer disease; CCCP: carbonyl cyanide 3-chlorophenylhydrazone; ECL: electrochemiluminescence; ELISA: enzyme-linked immunosorbent assay; iPSC: induced pluripotent stem cell; KO: knockout; LLOQ: lower limit of quantification; MSD: Meso Scale Discovery; PD: Parkinson disease; p-S65-Ub: serine-65 phosphorylated ubiquitin; Ub: ubiquitin; ULOQ: upper limit of quantification; WT: wild-type.
sj-pdf-1-aop-10.1177_1060028020983049 – Supplemental material for Characterization of Pharmacogenetic Information in Food and Drug Administration Drug Labeling and the Table of Pharmacogenetic Associations
Creators: name: Cheng, Christine M.
name: So, Thomas W.
name: Bubp, Jeff L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-aop-10.1177_1060028020983049 for Characterization of Pharmacogenetic Information in Food and Drug Administration Drug Labeling and the Table of Pharmacogenetic Associations by Christine M. Cheng, Thomas W. So and Jeff L. Bubp in Annals of Pharmacotherapy
Inhaltsverzeichnis
Creators: name: ,
Publisher: name: Institut für Christliche Sozialwissenschaften (ICS)
Year: 2016

description: Inhaltsverzeichnis des Bandes 57/2016
description: Jahrbuch für Christliche Sozialwissenschaften, Vol 57 (2016): Sozialethik der Pflege und Pflegepolitik
Chinese Pottery: Design through the Dynasties
Creators: name: Schalk, Nicole
Publisher: name: World Historical Gazetteer
publisherIdentifier: https://www.wikidata.org/wiki/Q130424771
publisherIdentifierScheme: Wikidata
Year: 2023
Subjects: subject: Historical geography
subject: Place names, History
subject: Geographical names, History
subject: Maps, Historical
subject: Historical regions

description: Diving into Art History, students will be viewing, describing, and learning about the various dynasties that have built the world of ceramics and the factors that influenced them. The objective is to better understand why people use the ceramic techniques for construction and glazing they do presently and the history behind these techniques.
E02636: Gregory of Tours, in his Glory of the Confessors (46), tells of the tombs of *Two priests of Bouliac (S02843), a village near Bordeaux (south-west Gaul); from their graves they join in chanting the psalms in the church where they are buried; and grant other benefits. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 46

Sunt etiam sub eiusdem territurii vico sepulti duo presbiteri, ut res ipsa declarat, aegregiae sanctitatis viri.
Nam eos post sepulchra vivere, ipsius rei miraculum quae geritur manifestissime docet. In una quidem sunt sepulti basilicam, sed e diversis parietibus. Nam unius eorum sepulchrum a parte austri, alterius habetur ad aquilonem. Igitur cum ad implendum officium clerici psallentium coeperint exercere et, choris a se factis, Domino turba canora concinere, mixtitur publico vox utriusque psallentio; et unus quidem chorus unius vocis adiutorio additur, alius vero alterius vocis modolamine convalescit. Tantaque est suavitatis huius concentus, ut audientium saepe mulceat adtentos auditos. Probantur et cum his plerumque indulgi beneficia, si fidelis oratio praemittatur. Agitur enim in vico Vodollacensi.

'Two priests are buried in a village in the territory of the same city [of Bordeaux]. These were men of outstanding holiness, as this event demonstrates. For the miracle that happened during this event clearly proves that they still live after their burial. The two priests are buried in the same church but against opposite walls. The tomb of one was on the south side, the tomb of the other on the north side. Later the clerics began to chant the psalms during the celebration of the [liturgical] office. When they had divided into choirs and [each] group sang songs to the Lord, the voice of each priest joined in the public chanting of the psalms. For one choir was augmented by the assistance of the voice of one priest, while the other choir gained strength from the melody of the other’s voice. This harmony was so sweet that it often delighted attentive listeners. In addition, benefits are often shown to be granted, if a faithful prayer is presented. This happened in the village of Bouliac.'

Text: Krusch 1969, 326. Translation: Van Dam 2004, 36-37, lightly modified.
Additional file 1 of Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease
Creators: name: Margara-Escudero, Hernando J.
name: Paz-Graniel, Indira
name: García-Gavilán, Jesús
name: Ruiz-Canela, Miguel
name: Sun, Qi
name: Clish, Clary B.
name: Toledo, Estefania
name: Corella, Dolores
name: Estruch, Ramón
name: Ros, Emilio
name: Castañer, Olga
name: Arós, Fernando
name: Fiol, Miquel
name: Guasch-Ferré, Marta
name: Lapetra, José
name: Razquin, Cristina
name: Dennis, Courtney
name: Deik, Amy
name: Li, Jun
name: Gómez-Gracia, Enrique
name: Babio, Nancy
name: Martínez-González, Miguel A.
name: Hu, Frank B.
name: Salas-Salvadó, Jordi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. Diagram of participant inclusion and analytical methodology. Table S1. Participant’s characteristics according to tertiles of energy-adjusted total legume consumption at one year of follow-up. Table S2. Correlations between the legume-related metabolites and other food groups and Mediterranean diet adherence. Table S3. Mean and SD metabolite coefficients associated to legume consumption. Table S4. Participant’s general characteristics according to T2D case-cohort database. Table S5. Participant’s general characteristics according to CVD case-cohort database. Table S6. Legume metabolite profile and risks of type 2 diabetes and cardiovascular disease by sex. Table S7. Legume metabolite profile and risk of type 2 diabetes and cardiovascular disease by intervention groups.
E02637: Floor-mosaic with a Greek inscription commemorating the paving of a church (naos) dedicated to *John the Baptist (S00020). Found at Riḥāb, between Bostra and Gerasa/Jerash (Jordan/Roman province of Arabia). Dated 604 or 619.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: The inscription is reportedly almost entirely complete. Here square brackets indicate passages which are not visible in the published photograph.

[+ ἐπὶ τ]οῦ ἁγιωτάτου καὶ μακαριωτάτου Πολυ[ε]ύκτου [ἀρχιεπισκ(όπου)]
[ἐψηφ]ώθη ὁ ναὸς οὗτος τοῦ ἁγίου (καὶ) Βαπτιστοῦ Ἰωάννου ἐκ [τῶν προσόδων (?)]
[τοῦ ἁγίο]υ τόπου, ἐκ σπουδῆς Γεωργίου πρεσβ(υτέρου) (καὶ) περιοδευτο[ῦ - - -]
[ἐν μην]ὶ Ἀπελλαίῳ, χρόνων ὀγδόης ἰνδικτιõνος τ[οῦ . . . ἔτους]

'+ Under the most holy and the most blessed [archbishop] Polyeuktos was paved this church (naos) of the holy and Baptist John from [the incomes (?)] of the holy place, through the zeal of the presbyter Georgios and itinerant priest (periodeutes) [- - -]. In the month of Apellaios, in the times of the eighth indiction of the [... year].'

Text: SEG 51, 2040. Translation: P. Nowakowski.

In 2011 Piccirillo published a translation based on a photograph of the complete text, which is slightly different from the provisional transcription in SEG, suggesting that the right-hand end is longer than it had been supposed:

'At the time of the most holy and blessed archbishop and metropolitan Polyeuktos, this temple of Saint John the Baptist of Neon Kastron (?) was paved with mosaics by George the priest and visitor and by Severus the steward, in the month of Apellaios, in the 8th indiction of the year 514 of the province [= November - December AD 619].'

Text and translation: Piccirillo 2011, 104-105.
Mobilitazione ambientale e anti-'ndrangheta di prossimità
Creators: name: Garofalo, Sabrina
Publisher: name: Rivista di Studi e Ricerche sulla criminalità organizzata
Year: 2017

description: La proposta ha come focus le diverse forme di partecipazione e solidarietà nella mobilitazione anti-’ndrangheta. In particolare, emerge che la mobilitazione legata ai temi ambientali rappresenta una nuova forma di partecipazione e di riconoscimento delle soggettività a partire da nuovi modi per declinare gli ancoraggi di prossimità. Lo studio delle dinamiche dei comitati ambientali nella provincia di Cosenza ha permesso di mettere a lavoro le nuove forme di solidarietà e di decostruzione del potere in quella che può essere definita anti-’ndrangheta di prossimità.

Parole Chiave: anti-'ndrangheta, mobilitazione, ambiente, territorio-prossimità

This paper is part of a research about the anti-‘ndrangheta movement, to share analysis about central elements about the experience of mobilization. Specifically, the research question focuses on new types of participation and solidarity, to recognise subjectivities in the de-construction of the power of the ‘ndrangheta. In particular, this analysis is rooted in the relationship between the environment, territory and fight against organised crime within the experience of environmental organisations in Calabria.

Key words: anti-'ndrangheta, mobilization, environment, territory, proximity
description: Rivista di Studi e Ricerche sulla criminalità organizzata, V. 3, N. 1 (2017): Rivista di Studi e Ricerche sulla criminalità organizzata
Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
Creators: name: Bui, Van
name: Liang, Xinwen
name: Ye, Yansheng
name: Giang, William
name: Tian, Fang
name: Takahashi, Yoshinori
name: Wang, Hong-Gang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer

description: Macroautophagy/autophagy, an evolutionarily conserved cellular degradation pathway, involves phagophores that sequester cytoplasmic constituents and mature into autophagosomes for subsequent lysosomal delivery. The ATG8 gene family, comprising the MAP1LC3/LC3 and GABARAP/GBR subfamilies in mammals, encodes ubiquitin-like proteins that are conjugated to phagophore membranes during autophagosome biogenesis. A central question in the field is how Atg8-family proteins are precisely involved in autophagosome formation, which remains controversial and challenging, at least in part due to the short lifespan of phagophores. In this study, we depleted the autophagosome closure regulator VPS37A to arrest autophagy at the vesicle completion step and determined the roles of mammalian Atg8-family proteins (mATG8s) in nutrient starvation-induced autophagosome biogenesis. Our investigation revealed that LC3 loss hinders phagophore formation, while GBR loss impedes both phagophore formation and expansion. The defect in membrane expansion by GBR loss appears to be attributed to compromised recruitment of ATG proteins containing an LC3-interacting region (LIR), including ULK1 and ATG3. Moreover, a combined deficiency of both LC3 and GBR subfamilies nearly completely inhibits phagophore formation, highlighting their redundant regulation of this process. Consequently, cells lacking all mATG8 members exhibit defects in downstream events such as ESCRT recruitment and autophagic flux. Collectively, these findings underscore the critical roles of mammalian Atg8-family proteins in phagophore formation and expansion during autophagy.Abbreviation: AIM: Atg8-family interacting motif; ADS: Atg8-interacting motif docking site; ATG: autophagy related; BafA1: bafilomycin A1; CL: control; ESCRT: endosomal sorting complex required for transport; FACS: fluorescence activated cell sorting; GBR: GABARAP; GBRL1: GABARAPL1; GBRL2: GABARAPL2; GBRL3: GABARAPL3; HKO: hexa-knockout; IP: immunoprecipitation; KO: knockout; LDS: LC3-interacting-region docking site; LIR: LC3-interacting region; mATG8: mammalian Atg8-family protein; MIL: membrane-impermeable ligands; MPL: membrane-permeable ligands; RT: room temperature; Stv: starved; TKO: triple-knockout; TMR: tetramethylrhodamine; UEVL: ubiquitin E2 variant-like; WCLs: whole cell lysates; WT: wild-type.
Role of capillary pressure on carbon dioxide sequestration: mathematical analysis
Creators: name: Pavan, Tummuri Naga Venkata
name: Devarapu, Srinivasa Reddy
name: Govindarajan, Suresh Kumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences

description: Geological disposal of CO2 after capturing the gas from large emitting sources is one of the safest and most prominent methods to eliminate CO2 from the atmosphere and mitigate climate change. The heterogeneities in porosity, permeability and capillary pressure in various underground formations impact gas distribution, affecting their storage capacity. Therefore, a numerical model is developed to study the plume migration under various physical heterogeneities by upscaling the variation in capillary pressure. Accordingly, homogeneous, heterogeneous and layered formations have been considered. The influence of capillary pressure and field-scale heterogeneities, such as porosity and permeability, is incorporated using the Leverett J function. The impact of variations in capillary pressure on gas migration is calibrated in different formations for ten years of injection. The analysis project that plume evolution in different formations highly deviates and a plume length of 3410 m is obtained for layered formation. A sensitivity analysis was conducted to understand the influence of interfacial tension in formations with differing heterogeneity. The change in interfacial tension impacts the average saturation of CO2, ranging from 0.287 to 0.155 in heterogeneous aquifers. The plume migration decreases in layered and increases in homogenous and heterogeneous media with decreased interfacial tension.
Additional file 1 of Lead generation of UPPS inhibitors targeting MRSA: Using 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamic simulations
Creators: name: Qandeel, Basma M.
name: Mowafy, Samar
name: Abouzid, Khaled
name: Farag, Nahla A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Induced fit docking interactions for the reference ligand (6TC) and the selected top five hits. Table S2. Interactions between the examined ligands (6TC and the selected top five hits) and the UPPS protein during the simulation run.
E02638: Gregory of Tours, in his Glory of the Confessors (48), writes of the graves of two saints in the territory of Cieutat (south-west Gaul) where miracles occur: *Justinus (priest of Saint-Justin-de-Pardiac, S01275) and *Similinus (priest of Tarbes, S01276). Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 48

Infra terminum autem Beorretanae urbis in vico Sexciacensi sanctus Iustinus presbiter quiescit.
Qui cum multis virtutibus polleat, saepius ad sepulchrum eius inergumini declamantes mundantur, [illuminantur caeci, paralitici diriguntur.] Huius merita ac sanctitate propinquus est Similinus, qui eiusdem ordinis officium in eclesia habuit. Qui apud Tarvam vicum huius territurii quiescit, similibus florens virtutibus.

'St Justinus the priest is buried within the territory of Cieutat in the village of Saint-Justin-de-Pardiac. He is distinguished for his many miracles; often possessed people who are shouting are cleansed at his tomb. Similinus,
who performed the duties of the same rank [of the priesthood] in the church, shares in his merits and holiness. Similinus is buried in Tarbes, a village in the territory [of Cieutat]; he flourishes with similar miracles.'

Text: Krusch 1969, 327. Translation: Van Dam 2004, 37.
Resource and recycling: a comprehensive review of India’s coal landscape, characterization, and the current to future potential of fly ash from thermal power plants
Creators: name: Naskar, Joyprakash
name: Sharma, Anil Kumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This study delves into a comprehensive review of coal mining, production, and consumption in India, focusing on thermal power plants and the generation of coal fly ash (CFA). It assesses CFA’s physicochemical properties and potential applications, as well as its environmental and technological management aspects. CFA, an industrial by-product, has gained importance due to increasing disposal challenges and environmental concerns. Reviewing global trends, the study highlights the economic, environmental, and sustainability implications of CFA utilization, emphasizing both opportunities and challenges. CFA has valuable properties for use in construction materials, agriculture, water purification, wastewater treatment, metal recovery, ceramics, and paint, contributing to environmental pollution mitigation and waste recycling. However, challenges such as metal leaching variability and logistical barriers hinder its widespread adoption. Regulatory support, including preferential recycling policies, is identified as critical to promoting CFA utilization. The future of CFA utilization in India looks promising, bolstered by initiatives like the “Swachh Bharat Mission” and the “National Clean Energy Fund.” Recommendations include optimizing CFA’s agricultural applications by studying long-term effects on soil health and productivity. Emerging technologies, such as blending CFA with organic and industrial wastes, biosolids, and innovative materials, hold the potential for enhancing sustainability, highlighting the need for further research.
Additional file 1 of The evaluation of cognitive-behavioral therapy-based intervention on type 2 diabetes patients with comorbid metabolic syndrome: a randomized controlled trial
Creators: name: Li, Yanni
name: Buys, Nicholas
name: Ferguson, Samantha
name: Li, Zhiyong
name: Shi, Yan-Chuan
name: Li, Li
name: Sun, Jing
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Neuroscience
Biotechnology
Chemical Sciences not elsewhere classified
Mental Health
Virology

description: Additional file 1: Figure S1. Intervention flow chart. Table S1. Patient participation details. Table S2. Intervention session contents.
E02639: Gregory of Tours, in his Glory of the Confessors (49-50), tells the story of *Severus (priest of the territory of Cieutat, S02844) who built two churches in the territory of Cieutat, equipping both with relics of saints; he miraculously blights a tree, but then revives it; a dead lily revives on the day of his feast. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Bryan
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 49-50

Summary:

49. The priest Severus, from a noble family, built two churches, almost twenty miles apart, in the territory of Cieutat and 'fortified both with the relics of saints (utrumque tamen sanctorum reliquiis communivit).' Every Sunday he rode between them to celebrate mass. One day while doing this he hit his head on a branch and cursed the tree, which immediately shrivelled up. Returning four days later and seeing the tree he prayed that God might revive it, which happened. He was buried in one of these churches. He was accustomed to gather lilies and hang them on the walls of this church.

50. Miracles show how good a life he led. A lily he had hung up in the church of his burial dried up completely; but when the day he left his body came round, it fully revived. 'Thus the blessed confessor offers new blossoms from his tomb (Et sic beatus confessor profert novos flores e tumulo).'

Text: Krusch 1969, 327-328. Summary: Katarzyna Wojtalik.
E02640: Gregory of Tours, in his Glory of the Confessors (51), tells of *Three priests (S02845) buried in the village of Aire-sur-l'Ardour (south-west Gaul), whose graves effect miracles and are slowly rising out of the ground. Written in Latin in Tours (north-west Gaul), 587/588.
Creators: name: Kwojtalik
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: Gregory of Tours, Glory of the Confessors 51

Summary

Three priest who were close companions, are buried next to each other in the territory of the vicus Iuliensis [Aire-sur-l'Adour, south-west Gaul]; they render this place famous by a constant succession of miracles (assiduitate miraculorum). The hard floor above their graves split open, exposing one tomb after another; the graves are continuing to rise year by year, so that one of them is now already fully exposed. This is a clear sign of the purity of the buried men.

Text: Krusch 1969, 328. Summary Katarzyna Wojtalik.
Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death
Creators: name: Alvarez-Valadez, Karla
name: Sauvat, Allan
name: Diharce, Julien
name: Leduc, Marion
name: Stoll, Gautier
name: Guittat, Lionel
name: Lambertucci, Flavia
name: Paillet, Juliette
name: Motino, Omar
name: Ferret, Lucille
name: Muller, Alexandra
name: Forveille, Sabrina
name: Maiuri, Maria Chiara
name: Kepp, Oliver
name: de Brevern, Alexandre G
name: Wodrich, Harald
name: Pol, Jonathan G
name: Kroemer, Guido
name: Djavaheri-Mergny, Mojgan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Cholesterol serves as a vital lipid that regulates numerous physiological processes. Nonetheless, its role in regulating cell death processes remains incompletely understood. In this study, we investigated the role of cholesterol trafficking in immunogenic cell death. Through cell-based drug screening, we identified two antidepressants, sertraline and indatraline, as potent inducers of the nuclear translocation of TFEB (transcription factor EB). Activation of TFEB was mediated through the autophagy-independent lipidation of MAP1LC3/LC3 (microtubule associated protein 1 light chain 3). Both compounds promoted cholesterol accumulation within lysosomes, resulting in lysosomal membrane permeabilization, disruption of autophagy and cell death that could be reversed by cholesterol depletion. Molecular docking analysis indicated that sertraline and indatraline have the potential to inhibit cholesterol binding to the lysosomal cholesterol transporters, NPC1 (NPC intracellular cholesterol transporter 1) and NPC2. This inhibitory effect might be further enhanced by the upregulation of NPC1 and NPC2 expression by TFEB. Both antidepressants also upregulated PLA2G15 (phospholipase A2 group XV), an enzyme that elevates lysosomal cholesterol. In cancer cells, sertraline and indatraline elicited immunogenic cell death, converting dying cells into prophylactic vaccines that were able to confer protection against tumor growth in mice. In a therapeutic setting, a single dose of each compound was sufficient to significantly reduce the outgrowth of established tumors in a T-cell-dependent manner. These results identify sertraline and indatraline as immunostimulatory agents for cancer treatment. More generally, this research shed light on novel therapeutic avenues harnessing lysosomal cholesterol transport to regulate immunogenic cell death.
Baicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity
Creators: name: Hao, Bingjie
name: Lin, Shumeng
name: Liu, Haipeng
name: Xu, Junfang
name: Chen, Li
name: Zheng, Tiansheng
name: Zhang, Wen
name: Dang, Yifang
name: Reiter, Russel J.
name: Li, Chaoqun
name: Zhai, Hong
name: Xia, Qing
name: Fan, Lihong
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: Immune checkpoint inhibitors, especially those targeting CD274/PD-L1yield powerful clinical therapeutic efficacy. Thoughmuch progress has been made in the development of antibody-basedCD274 drugs, chemical compounds applied for CD274degradation remain largely unavailable. Herein,baicalein, a monomer of traditional Chinese medicine, isscreened and validated to target CD274 and induces itsmacroautophagic/autophagic degradation. Moreover, we demonstrate thatCD274 directly interacts with MAP1LC3B (microtubule associatedprotein 1 light chain 3 beta). Intriguingly, baicalein potentiatesCD274-LC3 interaction to facilitate autophagic-lysosomal degradationof CD274. Importantly, targeted CD274. degradation via baicaleininhibits tumor development by boosting T-cell-mediated antitumorimmunity. Thus, we elucidate a critical role of autophagy-lysosomalpathway in mediating CD274 degradation, and conceptually demonstratethat the design of a molecular “glue” that tethers the CD274-LC3interaction is an appealing strategy to develop CD274 inhibitors incancer therapy. Abbreviations: ATTECs: autophagy-tethering compounds; AUTACs: AUtophagy-TArgeting Chimeras; AUTOTACs: AUTOphagy-TArgeting Chimeras; AMPK: adenosine 5‘-monophosphate (AMP)-activated protein kinase; BiFC: bimolecular fluorescence complementation; BafA1: bafilomycin A1; CD274/PD-L1/B7-H1: CD274 molecule; CQ: chloroquine; CGAS: cyclic GMP-AMP synthase; DAPI: 4’6-diamino-2-phenylindole; FITC: fluorescein isothiocyanate isomer; GFP: green fluorescent protein; GZMB: granzyme B; IHC: immunohistochemistry; ICB: immune checkpoint blockade; KO: knockout; KD: equilibrium dissociation constant; LYTAC: LYsosome-TArgeting Chimera; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MST: microscale thermophoresis; NFAT: nuclear factor of activated T cells; NFKB/NF-kB: nuclear factor kappa B; NSCLC: non-small-cell lung cancer; PDCD1: programmed cell death 1; PROTACs: PROteolysis TArgeting Chimeras; PRF1: perforin 1; PE: phosphatidylethanolamine; PHA: phytohemagglutinin; PMA: phorbol 12-myristate 13-acetate; STAT: signal transducer and activator of transcription; SPR: surface plasmon resonance; TILs: tumor-infiltrating lymphocyte; TME: tumor microenvironment.
Additional file 1 of Long-term monitoring of fatty acid oxidation defects: results from a MetabERN survey
Creators: name: Schwantje, Marit
name: Grünert, Sarah C.
name: Fuchs, Sabine A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: An overview of the questions and answer options included in the questionnaire on long-term monitoring of LCFAOD.