cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Electronic supplementary material: tables, simulation code and data from Selection bias in studies of human reproduction-longevity trade-offs
Creators: name: Helle, Samuli
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: A shorter lifespan as a potential cost of high reproductive effort in humans has intrigued researchers for more than a century. However, the results have been inconclusive so far and despite strong theoretical expectations we do not currently have compelling evidence for the longevity costs of reproduction. Using Monte Carlo simulation, it is shown here that a common practice in human reproduction-longevity studies using historical data (the most relevant data sources for this question), the omission of women who died prior to menopausal age from the analysis, results in severe underestimation of the potential underlying trade-off between reproduction and lifespan. In other words, assuming that such a trade-off is expressed also during reproductive years, the strength of the trade-off between reproduction and lifespan is progressively weakened when women dying during reproductive ages are sequentially and non-randomly excluded from the analysis. In cases of small sample sizes (e.g. few hundreds of observations), this selection bias by reducing statistical power may even partly explain the null results commonly found in this field. Future studies in this field should thus apply statistical approaches that account for or avoid selection bias in order to recover reliable effect size estimates between reproduction and longevity.
Tables S1-S3 from The deep history of the number words
Creators: name: Pagel, Mark
name: Meade, Andrew
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: We have previously shown that the ‘low limit’ number words (from one to five) have exceptionally slow rates of lexical replacement when measured across the Indo-European (IE) languages. Here, we replicate this finding within the Bantu and Austronesian language families, and with new data for the IE languages. Number words can remain stable for 10 000 to over 100 000 years, or around 3.5–20 times longer than average rates of lexical replacement among the Swadesh list of ‘fundamental vocabulary’ items. Ordinal evidence suggests that number words also have slow rates of lexical replacement in the Pama–Nyungan language family of Australia. We offer three hypotheses to explain these slow rates of replacement: (i) that the abstract linguistic-symbolic processing of ‘number’ links to evolutionarily conserved brain regions associated with numerosity; (ii) that number words are unambiguous and therefore have lower ‘mutation rates’; and (iii) that the number words occupy a region of the phonetic space that is relatively full and therefore resist change because alternatives are unlikely to be as ‘good’ as the original word.This article is part of the themed issue ‘The origins of numerical abilities’.
Additional Detail of Methods & Raw Data from Testing differential use of payoff-biased social learning strategies in children and chimpanzees
Creators: name: Vale, Gillian L.
name: Flynn, Emma G.
name: Kendal, Jeremy
name: Rawlings, Bruce
name: Hopper, Lydia M.
name: Schapiro, Steven J.
name: Lambeth, Susan P.
name: Kendal, Rachel L.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour

description: Various non-human animal species have been shown to exhibit behavioural traditions. Importantly, this research has been guided by what we know of human culture, and the question of whether animal cultures may be homologous or analogous to our own culture. In this paper, we assess whether models of human cultural transmission are relevant to understanding biological fundamentals by investigating whether accounts of human payoff-biased social learning are relevant to chimpanzees (Pan troglodytes). We submitted 4- and 5-year old children (N = 90) and captive chimpanzees (N = 69) to a token–reward exchange task. The results revealed different forms of payoff-biased learning across species and contexts. Specifically, following personal and social exposure to different tokens, children's exchange behaviour was consistent with proportional imitation, where choice is affected by both prior personally acquired and socially demonstrated token–reward information. However, when the socially derived information regarding token value was novel, children's behaviour was consistent with proportional observation; paying attention to socially derived information and ignoring their prior personal experience. By contrast, chimpanzees' token choice was governed by their own prior experience only, with no effect of social demonstration on token choice, conforming to proportional reservation. We also find evidence for individual- and group-level differences behaviour in both species. Despite the difference in payoff strategies used, both chimpanzees and children adopted beneficial traits when available. However, the strategies of the children are expected to be the most beneficial in promoting flexible behaviour by enabling existing behaviours to be updated or replaced with new and often superior ones.
Supplementary information for Knell and Martínez 2017 from Selective harvest focused on sexual signal traits can lead to extinction under directional environmental change
Creators: name: Knell, Robert J.
name: Martínez-Ruiz, Carlos
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Contains supplementary results, a full description of the model and the model code.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Cart. 189 (11 H 74), 316 folios, f. 0065v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0065v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0065v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: ADCO, Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Cart. 29 (G 134), 996 folios, f. 0496
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0496, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Septième cartulaire de Saint-Étienne de Dijon (1661-1665), Archives départementales de la Côte-d'Or, Cart. 29 (G 134), 996 folios, f. 0496, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Aggregate parameters and stability analysis from Delayed behavioural shifts undermine the sustainability of social–ecological systems
Creators: name: A.-S. Lafuite
name: C. De Mazancourt
name: M. Loreau
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Section 1 (table S1) presents the aggregate parameters of the model, their definition, and units. Section 2 (table S2) defines the parameters and gives the default values used for the simulations. Section 3 derives the analytical conditions for the local stability of the steady states.
Supplementary information on the mathematical model and supplementary figures from Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
Creators: name: Bocci, Federico
name: Mohit Kumar Jolly
name: Satyendra C. Tripathi
name: Aguilar, Mitzi
name: Hanash, Samir M.
name: Levine, Herbert
name: Onuchic, José N.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 29903 Medical Physics
subject: FOS: Physical sciences

description: Provides further information on the mathematical model and the experimental protocols.
Supplemental Information from Identifying spatio-temporal dynamics of Ebola in Sierra Leone using virus genomes
Creators: name: Gustafson, Kyle B.
name: Proctor, Joshua L.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional details of analysis
‘A Poor Prospect Indeed’: The State’s Disavowal of Child Abuse Victims in Youth Custody, 1960–1990
Creators: name: Jarman, Ben
name: Lanskey, Caroline
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: child abuse
youth justice
imprisonment
sexual abuse
safeguarding
child protection

description: Public seminar given at the Institute of Criminology on 31st October 2019. Presents the argument given in the 'Societies' journal article of the same name.
title: Flow Injection Analysis Concepts and Misconceptions
Creators: name: Tyson, Julian
Publisher: name: University of Massachusetts Amherst
Year: 1993
Subjects: subject: Chemistry

description: Aspects of definitions of analytical chemistry and flow injection analysis are discussed. The driving force in analytical research of cost-effectiveness is identified and the characteristics of flow injection examined. Basic concepts of fluid flow relevant to flow injection are explained and some common misconceptions concerning the magnitude of various phenomena examined. The implications fa the design of manifolds for high sensitivity are evaluated and some practical problems addressed. Novel features of FI, which take advantages of the kinetic nature of suitable processes, are identified and illustrated by some of Professor Ishibshi's work.
Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis
Creators: name: Tiam, Eric Robert
name: Bikobo, Dominique Serge Ngono
name: Zintchem, Auguste Abouem A
name: Nyemeck, Norbert Mbabi
name: Ndedi, Esther Del Florence Moni
name: Diboué, Patrick Hervé Betote
name: Nyegue, Maximilienne Ascension
name: Atchadé, Alex De Théodore
name: Pegnyemb, Dieudonné Emmanuel
name: Bochet, Christian G.
name: Koert, Ulrich
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D-glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, 1H and 13C and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 μg/mL.
Taxonomic affinities of the enigmatic Prionogale breviceps, early Miocene, Kenya
Creators: name: Borths, Matthew R.
name: Stevens, Nancy J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Prionogale breviceps is a tiny carnivorous mammal from the early Miocene of eastern Africa. Originally, specimens were interpreted as the adult morphology of the taxon. The dentition did not obviously align Prionogale with the carnivorous lineages present in Afro-Arabia during the early Miocene: Hyaenodonta and Carnivora. When Namasector was discovered in Namibia, the small taxa were placed together in Prionogalidae and aligned with Hyaenodonta. In this study, based on comparisons to hyaenodont specimens preserving deciduous dentition, the holotype of Prionogale is reinterpreted as preserving dP3 and dP4. Some of the lower dental specimens attributed to the taxon preserve dp4. The holotype of Namasector also preserves deciduous dental material. A phylogenetic analysis that includes deciduous dental characters for a broader sample of hyaenodonts resolved Prionogalidae as a clade. Understanding of the deciduous dentition of Prionogale allows future analyses to compare homologous morphology, and to explore the environmental factors that shaped carnivorous mammal evolution through the Miocene.
Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum
Creators: name: Vinh, Le Ba
name: Nguyen Thi Minh Nguyet
name: Yang, Seo Young
name: Kim, Jang Hoon
name: Nguyen Van Thanh
name: Nguyen Xuan Cuong
name: Nguyen Hoai Nam
name: Minh, Chau Van
name: Inkyu Hwang
name: Kim, Young Ho
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC50 values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.
Supplementary Material for: The Membrane Attack Complex/Perforin Superfamily
Creators: name: Moreno-Hagelsieb, G.
name: Vitug, B.
name: Medrano-Soto, A.
name: Saier Jr., M.H.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: The membrane attack complex/perforin (MACPF) superfamily consists of a diverse group of proteins involved in bacterial pathogenesis and sporulation as well as eukaryotic immunity, embryonic development, neural migration and fruiting body formation. The present work shows that the evolutionary relationships between the members of the superfamily, previously suggested by comparison of their tertiary structures, can also be supported by analyses of their primary structures. The superfamily includes the MACPF family (TC 1.C.39), the cholesterol-dependent cytolysin (CDC) family (TC 1.C.12.1 and 1.C.12.2) and the pleurotolysin pore-forming (pleurotolysin B) family (TC 1.C.97.1), as revealed by expansion of each family by comparison against a large protein database, and by the comparisons of their hidden Markov models. Clustering analyses demonstrated grouping of the CDC homologues separately from the 12 MACPF subfamilies, which also grouped separately from the pleurotolysin B family. Members of the MACPF superfamily revealed a remarkably diverse range of proteins spanning eukaryotic, bacterial, and archaeal taxonomic domains, with notable variations in protein domain architectures. Our strategy should also be helpful in putting together other highly divergent protein families.
MyGene2 automated match report: ZMIZ1
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for ZMIZ1.
Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis
Creators: name: Tiam, Eric Robert
name: Bikobo, Dominique Serge Ngono
name: Zintchem, Auguste Abouem A
name: Nyemeck, Norbert Mbabi
name: Ndedi, Esther Del Florence Moni
name: Diboué, Patrick Hervé Betote
name: Nyegue, Maximilienne Ascension
name: Atchadé, Alex De Théodore
name: Pegnyemb, Dieudonné Emmanuel
name: Bochet, Christian G.
name: Koert, Ulrich
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D-glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, 1H and 13C and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 μg/mL.
Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms
Creators: name: Du, Yunai
name: Wang, Sheng
name: Zhang, Tianhao
name: He, Dongsheng
name: Tu, Jiasheng
name: Shen, Yan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Receptor-mediated active targeting and tumor microenvironment responsive systems from polymeric micelles have been studied for rapid cellular internalization and triggered drug release. Previously we have constructed redox-responsive polymeric micelles composed of vitamin E succinate conjugated hyaluronic acid (HA-ss-TOS), which are able to actively target CD44 proteins and quickly release loaded drugs upon exposure to high levels of glutathione (GSH) in tumor cells. In the present study, we found that despite different cellular internalization mechanisms, micelles showed strong antineoplastic effects on 4T1 and B16F10 cells due to redox responsiveness. HA-ss-TOS-PTX micelles exhibited an excellent tumor targeting ability and prolonged retention time compared to Taxol in vivo. In addition, a superior antitumor effect was achieved compared to PTX-loaded insensitive micelles (HA-TOS-PTX) and Taxol. Our results revealed that PTX-loaded HA-ss-TOS micelles could enhance the antineoplastic efficacy of PTX for breast cancer and melanoma treatment and, thus, deserve further attention.
Fingerprinting Browsers in Encrypted Communications
Creators: name: Aneja, Sandhya
name: Aneja, Nagender
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cryptography and Security (cs.CR)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Browser fingerprinting is the identification of a browser through the network traffic captured during communication between the browser and server. This can be done using the HTTP protocol, browser extensions, and other methods. This paper discusses browser fingerprinting using the HTTPS over TLS 1.3 protocol. The study observed that different browsers use a different number of messages to communicate with the server, and the length of messages also varies. To conduct the study, a network was set up using a UTM hypervisor with one virtual machine as the server and another as a VM with a different browser. The communication was captured, and it was found that there was a 30\%-35\% dissimilarity in the behavior of different browsers.
description: 3 pages
Immunopathology in drug resistant mesial temporal lobe epilepsy with different types of hippocampal sclerosis
Creators: name: F. Irsel Tezer
name: Aysegul Firat
name: Tuzun, Erdem
name: Isik Unal
name: Soylemezoglu, Figen
name: Burcak Bilginer
name: Kaymaz, Figen
name: Oguz, Kader K.
name: Saygi, Serap
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Purpose: There is evidence that autoimmunity has a specific role in temporal lobe seizures of limbic encephalitis patients. Our aim in this study was to investigate any histopathological clues of autoimmune process in refractory temporal lobe epilepsy (TLE) patients with different pathologically proven hippocampal sclerosis (HS) types. Methods: 22 patients who had undergone epilepsy surgery due to mesial TLE-HS were included. The sera of patients are tested for neuronal antibodies to N-methyl-D-aspartate receptors (NMDAR), leucine-rich, glioma inactivated 1 (LGI1), contactin-associated protein 2 (CASPR2), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), gamma-aminobutyric acid B receptor (GABABR) and glutamic acid decarboxylase (GAD). Pathological and immunohistochemical investigations including neuronal nuclei (NeuN), NMDAR, GAD, glial fibrillary acidic protein (GFAP), CD8+-CD3+ lymphocytes and immunoglobulin G (IgG) were done. Patients were grouped according to type of HS. Clinical features and immunohistochemical changes were defined in these groups. Results: Available sera of 15 patients did not have any neuronal antibodies. Thirteen of 22 patients had HS type 1, three had HS type 2 and two had HS type 3. According to immunohistochemical investigations CD3+ and CD8+ T cell infiltration was more prominent in the hippocampus of patients with classical HS (International League Against Epilepsy (ILAE) Type 1 HS) and there was a significant negative correlation between epilepsy duration and numbers of CD3+-CD8+ lymphocytes in temporal lobe parenchyma. Conclusion: The role of T cell-mediated immunopathology and immunopathological difference in a variety of drug resistant TLE-H2S patients was suggested. These findings can be helpful in understanding the epileptogenicity of HS.
Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum
Creators: name: Vinh, Le Ba
name: Nguyen Thi Minh Nguyet
name: Yang, Seo Young
name: Kim, Jang Hoon
name: Nguyen Van Thanh
name: Nguyen Xuan Cuong
name: Nguyen Hoai Nam
name: Minh, Chau Van
name: Inkyu Hwang
name: Kim, Young Ho
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC50 values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.
Turning points or dead ends? Identity, desistance and the experience of imprisonment
Creators: name: Jarman, Ben
Publisher: name: Apollo - University of Cambridge Repository
Year: 2018
Subjects: life imprisonment
criminology
prisons
desistance
long-term imprisonment
risk needs responsivity
indeterminate imprisonment
england and wales
risk reduction
human agency

description: Desistance research has pushed criminologists to develop a nuanced conceptual account of criminal identity and human agency. However, these tools have mostly not been used to consider identity changes among long-sentenced prisoners, despite the growing preponderance of long-term imprisonment in England and Wales. As a result of this, desistance theory has not been used to evaluate the administration of indeterminate sentences, meaning that practitioners may be missing out on some of the insights that it can generate. This qualitative study begins to fill that gap, using a phenomenological analysis of eighteen in-depth semi-structured interviews with life- sentenced prisoners at a single prison in England, all of whom had been convicted of murder. It argues that most eventually attempt conscious projects of personal change during imprisonment; second, that many frame change in terms which are not consistent with the official discourses of risk reduction (which govern their progression through the sentence); and third, that how they themselves conceive and pursue personal change is affected by their position in the sentence and the life course, and also by the specific nature and circumstances of their index offences. The analysis classifies four different styles of agency found in the sample: ‘defensive’ and ‘fractured’ agents were unwilling or unable to accept responsibility for the offence, and were consequently in penal ‘dead ends’; while ‘corrective’ and ‘redemptive’ agents had encountered ‘turning points’, in that they accepted responsibility, albeit in different ways. The analysis describes each group’s characteristic ways of describing the offence and their part in it. It also describes their attitudes to prison social life in general, and to rehabilitative intervention in particular. The study as a whole suggests that much of the personal change which lifers themselves frame as significant happens outside rehabilitative interventions, and may be invisible to key prison staff. This raises important questions about whether prisons and prisoners think about rehabilitation in the same way, with consequences for the legitimacy of penal power.
description: None to declare.
Supplementary Material for: Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders
Creators: name: Spicer, T.P.
name: Hubbs, C.
name: Vaissiere, T.
name: Collia, D.
name: Rojas, C.
name: Kilinc, M.
name: Vick, K.
name: Madoux, F.
name: Baillargeon, P.
name: Shumate, J.
name: Martemyanov, K.A.
name: Page, D.T.
name: Puthanveettil, S.
name: Hodder, P.
name: Davis, R.
name: Miller, C.A.
name: Scampavia, L.
name: Rumbaugh, G.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: There is a pressing need to improve approaches for drug discovery related to neuropsychiatric disorders (NSDs). Therapeutic discovery in neuropsychiatric disorders would benefit from screening assays that can measure changes in complex phenotypes linked to disease mechanisms. However, traditional assays that track complex neuronal phenotypes, such as neuronal connectivity, exhibit poor scalability and are not compatible with high-throughput screening (HTS) procedures. Therefore, we created a neuronal phenotypic assay platform that focused on improving the scalability and affordability of neuron-based assays capable of tracking disease-relevant phenotypes. First, using inexpensive laboratory-level automation, we industrialized primary neuronal culture production, which enabled the creation of scalable assays within functioning neural networks. We then developed a panel of phenotypic assays based on culturing of primary neurons from genetically modified mice expressing HTS-compatible reporters that capture disease-relevant phenotypes. We demonstrated that a library of 1,280 compounds was quickly screened against both assays using only a few litters of mice in a typical academic laboratory setting. Finally, we implemented one assay in a fully automated high-throughput academic screening facility, illustrating the scalability of assays designed using this platform. These methodological improvements simplify the creation of highly scalable neuron-based phenotypic assays designed to improve drug discovery in CNS disorders.
Can people 'desist' in prison? Reflections on the implications of desistance theory for long-term imprisonment
Creators: name: Jarman, Ben
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: long-term imprisonment
desistance
criminology

description: Talk given at the Institute of Criminology in March 2019, setting out some findings and theoretical reflections arising from my MPhil research
Independent validation of the ICU requirement score in a cohort of acutely poisoned adults
Creators: name: Böll, Regina
name: Romanek, Katrin
name: Schmoll, Sabrina
name: Stich, Raphael
name: Ott, Armin
name: Stenzel, Jochen
name: Geith, Stefanie
name: Eyer, Florian
name: Rabe, Christian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Hematology
subject: 60506 Virology

description: Objective: To independently validate the predictive value of the intensive care requirement score (IRS) in unselected poisoned patients. Design: Retrospective chart review. Patients and methods: Five hundred and seventeen out of 585 admissions for acute intoxications could be analyzed. Eleven were excluded for a condition already requiring intensive care unit (ICU) support at admission (e.g., preclinical intubation). A further 57 admissions were excluded due to missing data. The IRS was calculated using a point-scoring system including age, Glasgow Coma Scale, heart rate, type of intoxication, and preexisting conditions. It was then compared to a composite endpoint indicating an ICU requirement (death in hospital, vasopressors, need for ventilation). The endpoint and the point-scoring system were identical to the original publication of the score. Results and conclusion: Twenty-three out of 517 patients had a complicated clinical course as defined by meeting the endpoint definition. Twenty-one out of 23 complicated courses had a positive IRS (defined as greater or equal 6 points), as compared to 255/494 patients with an uncomplicated clinical course (p
Merged supplementary file from Culture of an aphid heritable symbiont demonstrates its direct role in defence against parasitoids
Creators: name: Brandt, Jayce W.
name: Chevignon, Germain
name: Oliver, Kerry M.
name: Strand, Michael R.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Evolutionary Biology

description: Merged supplementary files consists of Table S1, S2, Figure S1, S2, S3, S4, and Supplemental References
Supplementary document for Rational design of an integrated directional coupler for wideband operation - 6756461.pdf
Creators: name: Passarelli, Nicolás
name: Palomba, Stefano
name: Kabakova, Irina
name: de Sterke, C. Martijn
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Equation 2
Palladium complex composites based on fullerene encapsulated in porous zinc porphyrin polymers
Creators: name: Shen, Tieyin
name: Chang, Zhaosen
name: Liu, Xin
name: Chen, Qi
name: Feng, Lijuan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Porphyrins and fullerenes were suitable for the construction of multi-component reticular polymer owing to the interaction of their coordination. In this work, a novel organic porous polymer (PPZ/C60) composed of metalloporphyrin and fullerene was designed and constructed. Compared with the traditional sawtooth structure, a fullerene encapsulated in porous zinc porphyrin polymers (PPZ/C60) was fabricated by the combination of covalent and non-covalent interaction based on the “porphyrin-fullerene-porphyrin” self-assembly system. Subsequently, the composites containing palladium complexes (PPZ/C60-Pd) were further constructed by the coordination between Pd(PPh3)4 and fullerene. Notably, the synthesized PPZ/C60 and PPZ/C60-Pd displayed an ample and stable structure of channel, high specific surface area (516 m2g−1, 452 m2g−1) and uniform pore size (0.77 nm, 0.66 nm). Furthermore, the PPZ/C60-Pd exhibited a significant catalytic performance in the deallylation reaction of 1,4-diprop-2-enoxybenzene with different side-chain groups. This work not only expanded the structure of this material, but also provided more possibilities for the application of the PPZ/C60-Pd.
Synthesis and Antiproliferative Evaluation of Novel 5-Substituted Pyridazin-4-Amine Derivatives
Creators: name: Liu, Bin
name: Xu, Xiaona
name: Tong, Hongjuan
name: Zhu, Zhoujing
name: Tang, Wenqiang
name: Tang, Chu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified

description: Synthesis and Antiproliferative Evaluation of Novel 5-Substituted Pyridazin-4-Amine Derivatives
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00150
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00150, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
Additional file 1 of Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications
Creators: name: Tan, Fei
name: Xuan, Yuan
name: Long, Lan
name: Yu, Yang
name: Zhang, Chunhua
name: Liang, Pengchen
name: Wang, Yaoqun
name: Chen, Meiyu
name: Wen, Jiling
name: Chen, Geng
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Table S1. Top 10 markers in each cell cluster used for determining corresponding cell types.
Supplementary document for Photothermal microfluidic-assisted self-cleaning effect for highly reusable SERS sensor - 5396861.pdf
Creators: name: Liu, Shaojing
name: Zhong, Huiqing
name: Li, Zongbao
name: Xu, Yu
name: Hu, Xiaowen
name: Zheng, Zhidong
name: Liu, Liu
name: Chen, PENGXIN
name: Cai, Xiang
name: Jiang, Xiaofang
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Surface Processes

description: Supplemental document
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0008
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0008, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0008, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Association of psychosis, affective disorders and diseases affecting the immune system
Creators: name: Larsen, Jeanette Brun
name: Iversen, Valentina Cabral
name: Reitan, Solveig Klæbo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Purpose of the article: There are indications of altered immune activity in depressed and psychotic patients compared to healthy controls in several studies. To explore the clinical importance of this phenomenon we examined the relation between different disorders affecting the immune system and psychoses and depression, respectively. Materials and methods: A total of 276 patients consecutively admitted to a psychiatric acute ward were included in the study. Of these 41 patients fulfilled the criteria for ICD-10 F20–29 (psychotic) diagnosis and 157 patients a F30–39 (affective) diagnosis. Information on diseases affecting the immune system in patients themselves and family members of the patients were obtained by a self-report questionnaire. Results: Comparing the two groups showed a significant correlation between the F20–29 group and eczema (r = −0.116, p = .037). Comparing what patients reported for family members showed a significantly higher frequency of epilepsy (p = .033) in the F20–29 group. Summarizing all immunological diseases for family members showed a significantly higher frequency in the F30–39 group compared to the F20–29 group (χ2 = 4, 82, df = 1, p = .028). Conclusions: There may be differences between the F20–29 and F30–39 groups and their family members regarding risk for diseases affecting the immune system. This is in line with different activity of the immune system measured in blood for the disorders and may add information regarding etiology and pathology of these psychiatric diseases. Further studies including a greater number of subjects, as well as confirmation of the immunological diseases through blood samples are needed.
Supplementary document for Eigenvalue calibration method for dual rotating-compensator Mueller matrix polarimetry - 5388803.pdf
Creators: name: Sheng, Sheng
name: Chen, Xiuguo
name: Chen, Chao
name: Zhuang, Jinfeng
name: Wang, Cai
name: Gu, Honggang
name: Liu, Shiyuan
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplement 1
title: Образы церковности в поэзии Аглаиды Шиманской и поэтика модернизма
Creators: name: Марков, Александр
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Поэзия Аглаиды Шиманской, эстетически зависимая от множества образцов модернистской поэзии (Блок, Ахматова, Пастернак, поэты «парижской ноты»), показывает оригинальность в соединении двух речевых узусов: церковного обихода и насыщенного символико-аллегорического толкования одних и тех же образов, причем обиходное выражение предшествует намеку на сложное соотношение аллегорий. Эти узусы благодаря сжатости поэтического выражения совмещаются, как правило, в пределах одной строки и характеризуют определенную культуру созерцания храмового пространства. Реконструируются источники такого совмещения узусов — рассказ А.П.Чехова «Святою ночью», поэзия Блока, поэзия и проза Пастернака. Также этот способ соединения двух разноплановых узусов вписан в более общие перипетии православной культуры в новое время. Перед нами убедительный проект сохранения живой русской речи в ситуации эмиграции, который может рассматриваться как один из вариантов развития любой эмигрантской литературы вообще.
Additional file 1 of FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer
Creators: name: Wang, Dongying
name: Wu, Shuying
name: He, Jiaxing
name: Sun, Luguo
name: Zhu, Hongming
name: Zhang, Yuxuan
name: Liu, Shanshan
name: Duan, Xuefeng
name: Wang, Yanhong
name: Xu, Tianmin
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1: Figure S1. Related to Fig. 4. (A&B) (A) Fluorescence-activated cell sorting (FACS) plots and (B) quantification of CD4+ PD-1+ in CD3+ TILs derived from sgFat4 or CTRL group. (C&D) (C) Fluorescence-activated cell sorting (FACS) plots and (D) quantification of CD8+ PD-1+ in CD3+ TILs derived from sgFat4 or CTRL group. All error bars are expressed as mean ± SD, ****P< 0.0001. Figure S2. Related to Fig. 5. (A) Ubiquitination of β-catenin protein in CTRL or FAT4 overexpression cells. Immunoprecipitation was performed with β-catenin antibody followed by immunoblotting with ubiquitin antibody. MG-132 (5μM; 24 h) treated CTRL cells as a positive control. (B) Immunofluorescence staining for FAT4 (red) and total-β-catenin (green) in U14 cells. In CTRL cells, the total-β-catenin runs throughout the cytoplasm, and sgFat4 is enriched in the cell membrane, with significant co-localization with FAT4. (C&D) Immunofluorescence staining for active-β-catenin and total-β-catenin in (C) ME180 and (D) U14 cells. FAT4 overexpression significantly inhibited the nuclear localization of active-β-catenin, total-β-catenin was detected throughout the cytoplasm (yellow arrow) in CTRL cells, and sgFAT4/sgFat4 was enriched for signaling signals at the cell membrane (white arrow). Figure S3. Related to Fig. 7 (A) Immunofluorescence analysis of CTRL or sgFat4 U14 cells for (left) co-localization of endogenous PD-L1 and endoplasmic reticulum maker (TGN38), (right) co-localization of endogenous PD-L1 and Golgi maker (Calreguli, CALR), nuclei stained with Hoechst (blue). (B&C) The Edu assay confirmed that PD-L1 overexpression in sgFAT4 ME180 cells could partially rescue the FAT4-induced proliferation inhibition (***P＜0.0010). (D&E) Intensity profiles showing signals from two fluorescent channels in Figure A. (F&G) T cell-mediated cancer cell killing assay. U14 CTRL and sgFat4 cells were co-cultured with activated T cells for 48 h and stained with crystal violet. U14 to T cell ratio 1:3. The normalized ratio of live cells in each well is shown. ***P< 0.001 and ****P< 0.0001. Supplementary Table 1. Antibody list.