cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Graf Albrecht II. und die Grafschaft Hohenberg, hg. v. Bernhard Rüth u. Andreas Zekorn
Creators: name: Eberl, Immo
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
$\mathfrak{gl}_n$-webs, categorification and Khovanov-Rozansky homologies
Creators: name: Tubbenhauer, Daniel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Algebra (math.QA)
subject: Geometric Topology (math.GT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In this paper we define an explicit basis for the $\mathfrak{gl}_n$-web algebra $H_n(\vec{k})$ (the $\mathfrak{gl}_n$ generalization of Khovanov's arc algebra) using categorified $q$-skew Howe duality. Our construction is a $\mathfrak{gl}_n$-web version of Hu--Mathas' graded cellular basis and has two major applications: it gives rise to an explicit isomorphism between a certain idempotent truncation of a thick calculus cyclotomic KLR algebra and $H_n(\vec{k})$, and it gives an explicit graded cellular basis of the $2$-hom space between two $\mathfrak{gl}_n$-webs. We use this to give a (in principle) computable version of colored Khovanov-Rozansky $\mathfrak{gl}_n$-link homology, obtained from a complex defined purely combinatorially via the (thick cyclotomic) KLR algebra and needs only $F$.
description: New version with additional results and an improved presentation, following a referee report. 59 pages, lots of figures, comments welcome. To appear in J. Knot Theory Ramifications
Long‐term effects of pallidal and thalamic deep brain stimulation in myoclonus dystonia
Creators: name: Krause, Patricia
name: Koch, Kristin
name: Gruber, Doreen
name: Kupsch, Andreas
name: Gharabaghi, Alireza
name: Schneider, Gerd‐Helge
name: Kühn, Andrea A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: dystonia
subject: myoclonus
subject: pallidal DBS
subject: thalamic DBS
subject: long-term effects
subject: DBS and quality of life
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Observational study to evaluate long-term effects of deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the ventral intermediate thalamic nucleus (VIM) on patients with medically refractory myoclonus dystonia (MD). Background: More recently, pallidal as well as thalamic DBS have been applied successfully in MD but long-term data are sparse. Methods: We retrospectively analyzed a cohort of seven MD patients with either separate (n = 1, VIM) or combined GPi- DBS and VIM-DBS (n = 6). Myoclonus, dystonia and disability were rated at baseline (BL), short-term (ST-FU) and long-term follow-up (LT-FU) using the United Myoclonus Rating Scale, Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and Tsui rating scale, respectively. Quality of life (QoL) and mood were evaluated using the SF-36 and Beck Depression Inventory questionnaires, respectively. Results: Patients reached a significant reduction of myoclonus at ST-FU (62% ± 7.3%; mean ± SE) and LT-FU (68% ± 3.4%). While overall motor BFMDRS changes were not significant at LT-FU, patients with GPi-DBS alone responded better and predominant cervical dystonia ameliorated significantly up to 54% ± 9.7% at long-term. Mean disability scores significantly improved by 44% ± 11.4% at ST-FU and 58% ± 14.8% at LT-FU. Mood and QoL remained unchanged between 5 and up to 20 years postoperatively. No serious long-lasting stimulation-related adverse events were observed. Conclusions: We present a cohort of MD patients with very long follow-up of pallidal and/or thalamic DBS that supports the GPi as the favourable stimulation target in MD with safe and sustaining effects on motor symptoms (myoclonus>dystonia) and disability.
No fixed limit for storing simple visual features: Realistic objects provide an efficient scaffold for holding features in mind
Creators: name: Störmer, Viola S.
name: Chung, Yong Hoon
name: Brady, Timothy
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Cognition and Perception
subject: Biological Psychology
subject: Psychology
subject: FOS: Psychology
subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Quantitative Psychology
subject: Experimental Analysis of Behavior
subject: meaningfulness
subject: working memory capacity
subject: color memory
subject: object recognition

description: Prominent theories of visual working memory postulate that the capacity to maintain a particular visual feature is fixed. In contrast to these theories, recent studies have demonstrated that meaningful objects are better remembered than simple, non-meaningful stimuli. Here, we test whether this is solely because meaningful stimuli can recruit additional features — and thus more storage capacity — or whether simple visual features that are not themselves meaningful can also benefit from being part of a meaningful object. Across five experiments (thirty young adults each) we demonstrate that visual working memory capacity for color is increased when colors are part of recognizable real-world objects compared to unrecognizable objects. Our results indicate that meaningful stimuli provide a potent scaffold to help maintain simple visual feature information, possibly because they effectively increase the objects’ distinctiveness from each other and reduce interference.
Liutold von Achalm († 1098), Graf und Klostergründer
Creators: name: Zimpel, Detlev
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Roland Deigendesch, Die Kartause Güterstein
Creators: name: Stievermann, Dieter
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
The Black Hole Mass Function Derived from Local Spiral Galaxies
Creators: name: Davis, Benjamin L.
name: Berrier, Joel C.
name: Johns, Lucas
name: Shields, Douglas W.
name: Hartley, Matthew T.
name: Kennefick, Daniel
name: Kennefick, Julia
name: Seigar, Marc S.
name: Lacy, Claud H. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present our determination of the nuclear supermassive black hole (SMBH) mass function for spiral galaxies in the Local Universe, established from a volume-limited sample consisting of a statistically complete collection of the brightest spiral galaxies in the Southern Hemisphere. Our SMBH mass function agrees well at the high-mass end with previous values given in the literature. At the low-mass end, inconsistencies exist in previous works that still need to be resolved, but our work is more in line with expectations based on modeling of SMBH evolution. This low-mass end of the spectrum is critical to our understanding of the mass function and evolution of SMBHs since the epoch of maximum quasar activity. A luminosity distance $\leq$ 25.4 $Mpc$ and an absolute B-band magnitude $\leq$ -19.12 define the sample. These limits define a sample of 140 spiral galaxies, with 128 measurable pitch angles to establish the pitch angle distribution for this sample. This pitch angle distribution function may be useful in the study of the morphology of late-type galaxies. We then use an established relationship between the pitch angle and the mass of the central SMBH in a host galaxy in order to estimate the mass of the 128 respective SMBHs in this sample. This result effectively gives us the distribution of mass for SMBHs residing in spiral galaxies over a lookback time $\leq$ 82.1 $h_{67.77}^{-1}$ $Myr$ and contained within a comoving volume of 3.37 $\times$ $10^4$ $h_{67.77}^{-3}$ $Mpc^3$. We estimate the density of SMBHs residing in spiral galaxies in the Local Universe is $5.54_{-2.73}^{+6.55}$ $\times$ $10^4$ $h_{67.77}^3$ $M_{\odot}$ $Mpc^{-3}$. Thus, our derived cosmological SMBH mass density for spiral galaxies is $Ω_{BH} = 4.35_{-2.15}^{+5.14}$ $\times$ $10^{-7}$ $h_{67.77}$.
description: 16 pages, 12 figures, 5 tables
Birgitt Maier, Kloster Kaisheim
Creators: name: Rückert, Maria Magdalena
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Partnership for Girls: Be Fit with Friends Physical Activity Mobile Units
Creators: name: Institute, Latino Research
Publisher: name: The University of Texas at Austin
Year: 2023
Subjects: Partnership for Girls
PA Partnership for Girls
Be Fit With Friends
Latina
Latino
Hispanic
urban
girls
physical activity
mental health
exercise
intervention

description: The Physical Activity Partnership for Girls was funded by the National Institute on Minority Health and Health Disparities (R24MD005096).
description: This record includes materials for the BFF Physical Activity Mobile Units, a program component of BFF Meetings. The program included a total of 5 PA Mobile Units: (1) Active Gaming with Kinect, (2) FlexiFun, (3) Time for Recess, (4) Active Gaming with Wii, and (5) Video Fitness. Learn more about this intervention component by reading the BFF Facilitator Training Manual.
Evaluating the Effectiveness of Personalized Medicine with Software
Creators: name: Kapelner, Adam
name: Bleich, Justin
name: Levine, Alina
name: Cohen, Zachary D.
name: DeRubeis, Robert J.
name: Berk, Richard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: We present methodological advances in understanding the effectiveness of personalized medicine models and supply easy-to-use open-source software. Personalized medicine involves the systematic use of individual patient characteristics to determine which treatment option is most likely to result in a better outcome for the patient on average. Why is personalized medicine not done more in practice? One of many reasons is because practitioners do not have any easy way to holistically evaluate whether their personalization procedure does better than the standard of care. Our software, "Personalized Treatment Evaluator" (the R package PTE), provides inference for improvement out-of-sample in many clinical scenarios. We also extend current methodology by allowing evaluation of improvement in the case where the endpoint is binary or survival. In the software, the practitioner inputs (1) data from a single-stage randomized trial with one continuous, incidence or survival endpoint and (2) a functional form of a model for the endpoint constructed from domain knowledge. The bootstrap is then employed on data unseen during model fitting to provide confidence intervals for the improvement for the average future patient (assuming future patients are similar to the patients in the trial). One may also test against a null scenario where the hypothesized personalization are not more useful than a standard of care. We demonstrate our method's promise on simulated data as well as on data from a randomized comparative trial investigating two treatments for depression.
description: 36 pages, 3 figures, 1 table
Benedict Kominiak (†), Jacques Coté, Cyrill Schäfer, Loci Ubi Deus Quaeritur
Creators: name: Scharfenecker, Uwe
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Sabine von Heusinger, Johannes Mulberg OP († 1414)
Creators: name: Wehrli-Johns, Martina
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
The decay $τ\rightarrow f_1 πν_τ$ in the Nambu--Jona-Lasinio model
Creators: name: Vishneva, A. V.
name: Volkov, M. K.
name: Kostunin, D. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The width of the decay $τ\rightarrow f_1 πν_τ$ has recently been measured by the BaBar experiment. The estimation of this width is given in the framework of the NJL model with the axial-vector mesons. Prediction is in agreement with the experimental data. It is shown that the $π-a_1$ transition contribution plays an important role and allows us to bring the NJL prediction to the data.
description: 3 pages, 3 figures
Roman Zehetmayer, Kloster und Gericht
Creators: name: Rückert, Maria Magdalena
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Württembergisches Klosterbuch. Klöster, Stifte und Ordensgemeinschaften von den Anfängen bis zur Gegenwart, hg. v. Wolfgang Zimmermann u. Nicole Priesching
Creators: name: Schaffer, Wolfgang
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Die deutschsprachigen Länder und das II. Vatikanum, hg. v. Hubert Wolf u. Claus Arnold
Creators: name: Bausenhart, Guido
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Subthalamic beta band suppression reflects effective neuromodulation in chronic recordings
Creators: name: Feldmann, Lucia K.
name: Neumann, Wolf‐Julian
name: Krause, Patricia
name: Lofredi, Roxanne
name: Schneider, Gerd‐Helge
name: Kühn, Andrea A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: biomarkers
subject: chronic LFP recordings
subject: deep brain stimulation
subject: neuromodulation
subject: Parkinson's disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and purpose: Biomarkers for future adaptive deep brain stimulation still need evaluation in clinical routine. Here, we aimed to assess stimulation-induced modulation of beta-band activity and clinical symptoms in a Parkinson's disease patient during chronic neuronal sensing using a novel implantable pulse generator. Methods: Subthalamic activity was recorded OFF and ON medication during a stepwise increase of stimulation amplitude. Off-line fast fourier transfom -based analysis of beta-band activity was correlated with motor performance rated from blinded videos. Results: The stepwise increase of stimulation amplitude resulted in decreased beta oscillatory activity and improvement of bradykinesia. Mean low beta-band (13-20 Hz) activity correlated significantly with bradykinesia (ρ = 0.662, p < 0.01). Conclusions: Motor improvement is reflected in reduced subthalamic beta-band activity in Parkinson's disease, supporting beta activity as a reliable biomarker. The novel PERCEPT neurostimulator enables chronic neuronal sensing in clinical routine. Our findings pave the way for a personalized precision-medicine approach to neurostimulation.
On the penetration distance in Garside monoids
Creators: name: Gebhardt, Volker
name: Tawn, Stephen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Group Theory (math.GR)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 20F36, 43A07 (Primary) 20M13, 20F69, 60B15 (Secondary)

description: We prove that the exponential growth rate of the regular language of penetration sequences is smaller than the growth rate of the regular language of normal form words, if the acceptor of the regular language of normal form words is strongly connected. Moreover, we show that the latter property is satisfied for all irreducible Artin monoids of spherical type, extending a result by Caruso. Our results establish that the expected value of the penetration distance $pd(x,y)$ in an irreducible Artin monoid of spherical type is bounded independently of the length of $x$, if $x$ is chosen uniformly among all elements of given canonical length and $y$ is chosen uniformly among all atoms; the latter in particular explains observations made by Thurston in the context of the braid group, and it shows that all irreducible Artin monoids of spherical type exhibit an analogous behaviour. Our results also give an affirmative answer to a question posed by Dehornoy.
description: Published version
Type of headache at onset and risk for complications in reversible cerebral vasoconstriction syndrome
Creators: name: Lange, Kristin Sophie
name: Forster, Ophélie
name: Mawet, Jérôme
name: Tuloup, Gabrielle
name: Burcin, Cécilia
name: Corti, Lucas
name: Duflos, Claire
name: Roos, Caroline
name: Ducros, Anne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: calcitonin gene-related peptide
subject: cerebrovascular diseases
subject: reversible cerebral vasoconstriction syndrome
subject: stroke
subject: thunderclap headache
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: In a recent Italian study, 30% of patients with reversible cerebral vasoconstriction syndrome (RCVS) presented without thunderclap headache (TCH), and tended to present more severe forms of RCVS than patients with TCH. We aimed to analyze the risk for complications of RCVS in patients with and without TCH at onset. Methods: In a pooled cohort of 345 French patients with RCVS, we compared patients with and without TCH at onset regarding rates of neurological complications, and the functional outcome at 3 months. Results: As compared to the 281 patients with TCH at onset, the 64 patients without TCH had a higher risk for any neurological complication (61% vs. 24%, OR 4.9, 95% CI 2.8-8.7, p < 0.001). The association was strongest for cervical artery dissections (28% vs. 5%, OR 8.1, 95% CI 3.7-17.6, p < 0.001), followed by posterior reversible encephalopathy syndrome (17% vs. 3%, OR 7.1, 95% CI 2.7-18.4, p < 0.001), seizures (9% vs. 2.5%, OR 4.1, 95% CI 1.3-12.5, p = 0.019), and subarachnoid hemorrhage (41% vs. 16%, OR 3.5, 95% CI 1.9-6.3, p < 0.001). In multivariable analysis, the risk for any neurological complication remained significantly elevated in the absence of TCH (OR 3.5, 95% CI 1.8-6.8, p < 0.001). The functional outcome was equal in both groups, with a modified Rankin scale score of 0-1 in ≥90% of patients. Conclusions: Absence of TCH at onset might predict a higher risk of complications in RCVS. Our results warrant further multicentric studies to prove this finding.
Michael F. Feldkamp, Pius XII. und Deutschland
Creators: name: Scheidgen, Hermann-Josef
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Yet another proof of the Morse index theorem
Creators: name: Portaluri, Alessandro
name: Waterstraat, Nils
Publisher: name: arXiv
Year: 2013
Subjects: subject: Differential Geometry (math.DG)
subject: Functional Analysis (math.FA)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics
subject: 58E10

description: We give a new analytical proof of the Morse index theorem for geodesics in Riemannian manifolds.
description: 9 pages; v2: final version, minor changes
Georg Denzler, Widerstand ist nicht das richtige Wort
Creators: name: Weiß, Otto
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Orders of Nikshych's Hopf algebra
Creators: name: Cuadra, Juan
name: Meir, Ehud
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 16T05, 18D10, 16G30, 14L15

description: Let $p$ be an odd prime number and $K$ a number field having a primitive $p$-th root of unity $ζ.$ We prove that Nikshych's non-group theoretical Hopf algebra $H_p$, which is defined over $\mathbb{Q}(ζ)$, admits a Hopf order over the ring of integers $\mathcal{O}_K$ if and only if there is an ideal $I$ of $\mathcal{O}_K$ such that $I^{2(p-1)} = (p)$. This condition does not hold in a cyclotomic field. Hence this gives an example of a semisimple Hopf algebra over a number field not admitting a Hopf order over any cyclotomic ring of integers. Moreover, we show that, when a Hopf order over $\mathcal{O}_K$ exists, it is unique and we describe it explicitly.
description: 33 pages. Major changes in the presentation
Exploring hypergraphs with martingales
Creators: name: Bollobás, Béla
name: Riordan, Oliver
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C80

description: Recently, we adapted exploration and martingale arguments of Nachmias and Peres, in turn based on ideas of Martin-Löf, Karp and Aldous, to prove asymptotic normality of the number $L_1$ of vertices in the largest component $C$ of the random $r$-uniform hypergraph throughout the supercritical regime. In this paper we take these arguments further to prove two new results: strong tail bounds on the distribution of $L_1$, and joint asymptotic normality of $L_1$ and the number $M_1$ of edges of $C$. These results are used in a separate paper "Counting connected hypergraphs via the probabilistic method" to enumerate sparsely connected hypergraphs asymptotically.
description: 32 pages; significantly expanded presentation. To appear in Random Structures and Algorithms
High-Fidelity Single-Qubit Gates for Two-Electron Spin Qubits in GaAs
Creators: name: Cerfontaine, Pascal
name: Botzem, Tim
name: DiVincenzo, David P.
name: Bluhm, Hendrik
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Single-qubit operations on singlet-triplet qubits in GaAs double quantum dots have not yet reached the fidelities required for fault-tolerant quantum information processing. Considering experimentally important constraints and using measured noise spectra, we numerically minimize the effect of decoherence (including high-frequency 1/f-like noise) and show theoretically that quantum gates with fidelities higher than 99.9% are achievable. We also present a self-consistent tuning protocol which should allow the elimination of individual systematic gate errors directly in an experiment.
description: 5 pages, 4 figures
Heike Kreutzer, Das Reichskirchenministerium im Gefüge der nationalsozialistischen Herrschaft
Creators: name: Feldkamp, Michael F.
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Quantum many-body models with cold atoms coupled to photonic crystals
Creators: name: Douglas, J. S.
name: Habibian, H.
name: Hung, C. -L.
name: Gorshkov, A. V.
name: Kimble, H. J.
name: Chang, D. E.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Using cold atoms to simulate strongly interacting quantum systems represents an exciting frontier of physics. However, as atoms are nominally neutral point particles, this limits the types of interactions that can be produced. We propose to use the powerful new platform of cold atoms trapped near nanophotonic systems to extend these limits, enabling a novel quantum material in which atomic spin degrees of freedom, motion, and photons strongly couple over long distances. In this system, an atom trapped near a photonic crystal seeds a localized, tunable cavity mode around the atomic position. We find that this effective cavity facilitates interactions with other atoms within the cavity length, in a way that can be made robust against realistic imperfections. Finally, we show that such phenomena should be accessible using one-dimensional photonic crystal waveguides in which coupling to atoms has already been experimentally demonstrated.
Foveal changes in aquaporin‐4 antibody seropositive neuromyelitis optica spectrum disorder are independent of optic neuritis and not overtly progressive
Creators: name: Roca‐Fernández, Adriana
name: Oertel, Frederike Cosima
name: Yeo, Tianrong
name: Motamedi, Seyedamirhosein
name: Probert, Fay
name: Craner, Matthew J.
name: Sastre‐Garriga, Jaume
name: Zimmermann, Hanna G.
name: Asseyer, Susanna
name: Kuchling, Joseph
name: Bellmann‐Strobl, Judith
name: Ruprecht, Klemens
name: Leite, Maria Isabel
name: Paul, Friedemann
name: Brandt, Alexander Ulrich
name: Palace, Jacqueline
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: aquaporin-4 antibodies (AQP4-IgG)
subject: foveal morphometry
subject: neuromyelitis optica spectrum disorders (NMOSD)
subject: optic neuritis
subject: retinal neuroaxonal damage
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and purpose: Foveal changes were reported in aquaporin-4 antibody (AQP4-Ab) seropositive neuromyelitis optica spectrum disorder (NMOSD) patients; however, it is unclear whether they are independent of optic neuritis (ON), stem from subclinical ON or crossover from ON in fellow eyes. Fovea morphometry and a statistical classification approach were used to investigate if foveal changes in NMOSD are independent of ON and progressive. Methods: This was a retrospective longitudinal study of 27 AQP4-IgG + NMOSD patients (49 eyes; 15 ON eyes and 34 eyes without a history of ON [NON eyes]), follow-up median (first and third quartile) 2.32 (1.33-3.28), and 38 healthy controls (HCs) (76 eyes), follow-up median (first and third quartile) 1.95 (1.83-2.54). The peripapillary retinal nerve fibre layer thickness and the volume of combined ganglion cell and inner plexiform layer as measures of neuroaxonal damage from ON were determined by optical coherence tomography. Nineteen foveal morphometry parameters were extracted from macular optical coherence tomography volume scans. Data were analysed using orthogonal partial least squares discriminant analysis and linear mixed effects models. Results: At baseline, foveal shape was significantly altered in ON eyes and NON eyes compared to HCs. Discriminatory analysis showed 81% accuracy distinguishing ON vs. HCs and 68% accuracy in NON vs. HCs. NON eyes were distinguished from HCs by foveal shape parameters indicating widening. Orthogonal partial least squares discriminant analysis discriminated ON vs. NON with 76% accuracy. In a follow-up of 2.4 (20.85) years, no significant time-dependent foveal changes were found. Conclusion: The parafoveal area is altered in AQP4-Ab seropositive NMOSD patients suggesting independent neuroaxonal damage from subclinical ON. Longer follow-ups are needed to confirm the stability of the parafoveal structure over time.
Treatment expectations and perception of therapy in adult patients with spinal muscular atrophy receiving nusinersen
Creators: name: Meyer, Thomas
name: Maier, André
name: Uzelac, Zeljko
name: Hagenacker, Tim
name: Günther, René
name: Schreiber‐Katz, Olivia
name: Weiler, Markus
name: Steinbach, Robert
name: Weyen, Ute
name: Koch, Jan Christoph
name: Kettemann, Dagmar
name: Norden, Jenny
name: Dorst, Johannes
name: Wurster, Claudia
name: Ludolph, Albert C.
name: Stolte, Benjamin
name: Freigang, Maren
name: Osmanovic, Alma
name: Petri, Susanne
name: Grosskreutz, Julian
name: Rödiger, Annekathrin
name: Griep, Ramona
name: Gaudlitz, Marcel
name: Walter, Bertram
name: Münch, Christoph
name: Spittel, Susanne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: nusinersen
subject: spinal muscle atrophy
subject: treatment satisfaction
subject: treatment expectations
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and purpose: This was an investigation of treatment expectations and of the perception of therapy in adult patients with 5q-associated spinal muscular atrophy (5q-SMA) receiving nusinersen. Methods: A prospective, non-interventional observational study of nusinersen treatment in adult 5q-SMA patients was conducted at nine SMA centers in Germany. The functional status, treatment expectations and perceived outcomes were assessed using the Amyotrophic Lateral Sclerosis Functional Rating Scale-extended (ALS-FRS-ex), the Measure Yourself Medical Outcome Profile (MYMOP2), the Treatment Satisfaction Questionnaire for Medication (TSQM-9) and the Net Promoter Score (NPS). Results: In all, 151 patients were included with a median age of 36 years (15-69 years). SMA type 3 (n = 90, 59.6%) prevailed, followed by type 2 (33.8%) and type 1 (6.6%). In SMA types 1-3, median ALS-FRS-ex scores were 25, 33 and 46 (of 60 scale points), respectively. MYMOP2 identified distinct treatment expectations: head verticalization (n = 13), bulbar function (n = 16), arm function (n = 65), respiration (n = 15), trunk function (n = 34), leg function (n = 76) and generalized symptoms (n = 77). Median symptom severity decreased during nusinersen treatment (median observational period 6.1 months, 0.5-16 months) from 3.7 to 3.3 MYMOP2 score points (p < 0.001). The convenience of drug administration was critical (49.7 of 100 TSQM-9 points, SD 22); however, the overall treatment satisfaction was high (74.3, SD 18) and the recommendation rating very positive (NPS +66). Conclusions: Nusinersen was administered across a broad range of ages, disease durations and motor function deficits. Treatment expectations were highly differentiated and related to SMA type and functional status. Patient-reported outcomes demonstrated a positive perception of nusinersen therapy in adult patients with 5q-SMA.
Fully Bayesian Logistic Regression with Hyper-Lasso Priors for High-dimensional Feature Selection
Creators: name: Li, Longhai
name: Yao, Weixin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation (stat.CO)
subject: Methodology (stat.ME)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: 62J07

description: High-dimensional feature selection arises in many areas of modern science. For example, in genomic research we want to find the genes that can be used to separate tissues of different classes (e.g. cancer and normal) from tens of thousands of genes that are active (expressed) in certain tissue cells. To this end, we wish to fit regression and classification models with a large number of features (also called variables, predictors). In the past decade, penalized likelihood methods for fitting regression models based on hyper-LASSO penalization have received increasing attention in the literature. However, fully Bayesian methods that use Markov chain Monte Carlo (MCMC) are still in lack of development in the literature. In this paper we introduce an MCMC (fully Bayesian) method for learning severely multi-modal posteriors of logistic regression models based on hyper-LASSO priors (non-convex penalties). Our MCMC algorithm uses Hamiltonian Monte Carlo in a restricted Gibbs sampling framework; we call our method Bayesian logistic regression with hyper-LASSO (BLRHL) priors. We have used simulation studies and real data analysis to demonstrate the superior performance of hyper-LASSO priors, and to investigate the issues of choosing heaviness and scale of hyper-LASSO priors.
description: 33 pages. arXiv admin note: substantial text overlap with arXiv:1308.4690
Schweizer Katholizismus 1933-1945
Creators: name: Pahud De Mortanges, Elke
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
title: Création de collectif au sein d'une séquence en arts visuels
title: Création de collectif au sein d'une séquence en arts visuels
titleType: AlternativeTitle
Creators: name: Delfosse, Viviane
Publisher: name: Unknown
Year: 0
Subjects: subject: collectif
subject: collaboration
subject: idées
subject: créativité
subject: arts visuels
subject: théorisation ancrée

description: L’apport d’une séquence collaborative et collective dans le cadre de l'enseignement d'une séquence en AVI avec des élèves de 7 H a permis d’observer une prise d’autonomie de la part de plusieurs élèves ainsi qu’un développement de collectivité dans la construction d’un « esprit de classe » notable. L’intérêt le plus significatif d’une séquence ainsi menée nous amène à la mise en lumière d’apprentissages sociaux effectifs plus importants que plastiques, ce qui encourage le développement de l’élève comme un individu, futur acteur de la société dans laquelle il évolue. La créativité, au travers d’échanges d’idées, s’est alors transformée en levier d’apprentissage lors de collaboration et de collectivité. Dans le cadre de ce mémoire, nous avons adopté une théorisation ancrée (grounded theory), démarche de recherche inductive. A partir des différents entretiens et observations, nous en sommes arrivés à la mise en forme d’un processus d’échange dans lequel deux tensions apparaissent entre la recherche des idées et la collaboration. La stimulation de la créativité des élèves dans un contexte de collaboration a engendré une création de relation humaine primant sur la création artistique. La découverte d’une telle dimension nous permet de rendre compte des apprentissages sociaux (savoir être) qui peuvent se faire au sein de la discipline n’étant plus réduits, comme souvent, à seuls des savoirs techniques (savoir faire).
Probing CP Violation in $h\rightarrowγγ$ with Converted Photons
Creators: name: Bishara, Fady
name: Grossman, Yuval
name: Harnik, Roni
name: Robinson, Dean J.
name: Shu, Jing
name: Zupan, Jure
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study Higgs diphoton decays, in which both photons undergo nuclear conversion to electron- positron pairs. The kinematic distribution of the two electron-positron pairs may be used to probe the CP violating (CPV) coupling of the Higgs to photons, that may be produced by new physics. Detecting CPV in this manner requires interference between the spin-polarized helicity amplitudes for both conversions. We derive leading order, analytic forms for these amplitudes. In turn, we obtain compact, leading-order expressions for the full process rate. While performing experiments involving photon conversions may be challenging, we use the results of our analysis to construct experimental cuts on certain observables that may enhance sensitivity to CPV. We show that there exist regions of phase space on which sensitivity to CPV is of order unity. The statistical sensitivity of these cuts are verified numerically, using dedicated Monte-Carlo simulations.
description: 49 pages, 15 figures; updated to match JHEP and fixed minor typos
title: Radiation Therapy in the German Hodgkin Study Group HD 16 and HD 17 Trials: Quality Assurance and Dosimetric Analysis for Hodgkin Lymphoma in the Modern Era
Creators: name: Oertel, Michael
name: Hering, Dominik Alexander
name: Nacke, Nina
name: Kittel, Christopher
name: Kröger, Kai Jannes
name: Kriz, Jan
name: Fuchs, Michael
name: Baues, Christian Manfred
name: Vordermark, Dirk
name: Engenhart, Rita
name: Herfarth, Klaus
name: Lukas, Peter
name: Schmidberger, Heinz
name: Marnitz-Schulze, Simone
name: Borchmann, Peter
name: Engert, Andreas
name: Haverkamp, Uwe
name: Eich, Hans-Theodor
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 610 Medicine and health

description: Purpose: Radiation therapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. This analysis reports on RT quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods and Materials: All RT plans of involved-node radiation therapy (INRT) in HD 17 were requested for analysis, along with 100 and 50 involved-field radiation therapy (IFRT) plans in HD 16 and 17, respectively. A structured assessment regarding field design and protocol adherence was performed by the reference radiation oncology panel of the GHSG. Results: Overall, 100 (HD 16) and 176 (HD 17) patients were eligible for analysis. In HD 16, 84% of RT series were evaluated as correct, with significant improvement compared with the predecessor studies (P < .001). In HD 17, 76.1% of INRT cases revealed a correct RT design compared with 69.0% of IFRT-cases, which was superior to previous studies (P < .001). Comparing INRT and IFRT, we found no significant differences in the percentage of any deviation (P = .418) or major deviations (P = .466). Regarding dosimetry, INRT was accompanied by an improvement in thyroid doses. Comparing different RT techniques, we found that intensity-modulated RT showed a reduction of high doses in the lung at the expense of an increased low-dose exposure in HD 17. Conclusions: The latest study generation of the GHSG demonstrates an improved quality in RT. A modern INRT design could be established without deterioration in quality. On a conceptual level, an individual consideration of the appropriate RT technique has to be performed.
description: Finanziert durch den Open-Access-Publikationsfonds der Universität Münster.
Moduli spaces of bundles over non-projective K3 surfaces
Creators: name: Perego, Arvid
name: Toma, Matei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: We study moduli spaces of sheaves over non-projective K3 surfaces. More precisely, if $v=(r,ξ,a)$ is a Mukai vector on a K3 surface $S$ with $r$ prime to $ξ$ and $ω$ is a "generic" Kähler class on $S$, we show that the moduli space $M$ of $μ_ω-$stable sheaves on $S$ with associated Mukai vector $v$ is an irreducible holomorphic symplectic manifold which is deformation equivalent to a Hilbert scheme of points on a K3 surface. If $M$ parametrizes only locally free sheaves, it is moreover hyperkähler. Finally, we show that there is an isometry between $v^{\perp}$ and $H^{2}(M,\mathbb{Z})$ and that $M$ is projective if and only if $S$ is projective.
description: 42 pages; major revisions; to appear in Kyoto J. Math
Patients’ self‐reported physical and psychological effects of opioid use in chronic noncancer pain—A retrospective cross‐sectional analysis
Creators: name: Schulte, Erika
name: Spies, Claudia
name: Denke, Claudia
name: Meerpohl, Joerg J.
name: Donner‐Banzhoff, Norbert
name: Petzke, Frank
name: Hertwig, Ralph
name: Schäfer, Michael
name: Wegwarth, Odette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Opioid
subject: Chronic noncancer pain
subject: Physical and psychological effects
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Strong opioids can have unintended effects. Clinical studies of strong opioids mainly report physical side effects, psychiatric or opioid use disorders. To date, too little attention has been paid to the psychological effects of opioids to treat patients with chronic noncancer pain (CNCP). This study aims to identify and measure (i) the nature and frequency of physical and psychological effects and (ii) the degree of physician counseling of patients with CNCP taking strong opioids. Methods: Within a cross-sectional survey-conducted as part of a randomised controlled online intervention trial (ERONA [Experiencing the risk of overusing opioids among patients with chronic non-cancer pain in ambulatory care])-300 German CNCP patients were surveyed via patient-reported outcome measures regarding on both the side effects from their use of strong opioids as well as their counselling experience. Results: Among the patients' reported effects, the psychological outcomes of the opioids in CNCP were: feeling relaxed (84%), fatigue (76%), dizziness (57%), listlessness (37%), difficulty with mental activities (23%), dulled emotions (17%) and poor memory (17%). Ninety-two per cent of the patients reported having received information about opioid effects, and 46% had discussed cessation of the opioid medication with their physicians before commencing the prescription. Conclusions: In addition to the well-known physical side effects, patients with CNCP taking strong opioids experience significant psychological effects. In view of these effects, discontinuation of opioid therapy should be discussed early to ensure their benefits do not outweigh their harm. Significance: In this study, patients with non-cancer pain notice that opioids they have taken do not only cause physical side effects but also may have an impact on their psyche and their emotions and, thus, may also affect quality of life substantially. Clinical trial number: DRKS00020358.
Continuous rational maps into spheres
Creators: name: Kucharz, Wojciech
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14P05, 14P25, 57R99

description: Let X be a compact nonsingular real algebraic variety. We prove that if a continuous map from X into the unit p-sphere is homotopic to a continuous rational map, then, under certain assumptions, it can be approximated in the compact-open topology by continuous rational maps. As a byproduct, we also obtain some results on approximation of smooth submanifolds by nonsingular subvarieties.
description: To appear in Mathematische Zeitschrift
Das Christentum und die totalitären Eierausforderungen des 20. Jahrhunderts
Creators: name: Schratz, Sabine
Publisher: name: Rottenburger Jahrbuch für Kirchengeschichte
Year: 1970

description: Rottenburger Jahrbuch für Kirchengeschichte, Bd. 22 (2003): Rottenburger Jahrbuch für Kirchengeschichte, Band 22
Modern flow chemistry – prospect and advantage
Creators: name: Heretsch, Philipp
Publisher: name: Frankfurt, Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Year: 2023
Subjects: subject: flow chemistry
subject: method development
subject: reactor design
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: [no abstract available]
Identification of chemotherapy resistance drivers in breast cancer cells
Creators: name: Kumar, Uttom
Publisher: name: Imperial College London
Year: 2021

description: Breast cancer is a heterogenous disease with some subtypes posing a significant treatment challenge due to lack of targeted therapies and chemoresistance, particularly triple-negative metaplastic breast carcinoma (MBC). Here, I report a novel triple-negative MBC derived cell line, BAS, which showed a molecular and phenotypic diversity to the only existing metaplastic HS578T cells. To gain insight behind the chemotherapeutic resistance, I generated doxorubicin (HS-DOX, BAS-DOX) and paclitaxel (HS-TX, BAS-TX) resistant derivatives of both HS578T and BAS cells. Drug sensitivity assays indicated that doxorubicin- and paclitaxel-resistant cells showed a truly multidrug resistant (MDR) phenotype. Both BAS-DOX and BAS-TX showed significant up-regulation of transcription factor FOXC1 and its experimental down-regulation re-sensitized cells to doxorubicin and paclitaxel. Moreover, experimental modulation of FOXC1 expression in MCF-7 and MDA-MB-231 cells corroborated its role in MDR. Genome-wide expression analyses identified up-regulation of TGFB2 in both BAS-DOX and BAS-TX cells. Pharmacological inhibition of the TGF-β pathway reduced FOXC1 expression and increased drug sensitivity in both BAS-DOX and BAS-TX cells. MicroRNA (miR) expression profiling identified higher endogenous miR-495-3p levels in parental BAS cells that were significantly down-regulated in both BAS MDR cells. Over-expression of miR-495-3p in BAS MDR cells led to re-sensitization to doxorubicin and paclitaxel and down-regulation of TGFB2 and FOXC1, whereas miR-495-3p inhibition in parental BAS cells led to opposite effects. Moreover, miR expression analysis in breast cancer clinical samples identified a miR signature discriminating MBC from invasive ductal carcinoma (IDC). Additionally, transcription factor FOXA1 also contributes to the MDR in breast cancer cells. Experimental down-regulation of FOXA1 in MCF-7 and T47D cells increased doxorubicin and paclitaxel sensitivity, whereas its over-expression in MDA-MB-231 cells increased resistance to both drugs. Overall, the present study reveals some novel regulators of chemoresistance in breast cancer cells and thus opens the exploration of new therapeutic strategies.
Arginase 1+ IL-10+ polymorphonuclear myeloid-derived suppressor cells are elevated in patients with active pemphigus and correlate with an increased Th2/Th1 response
Creators: name: Neri, Davide
name: Carevic‐Neri, Melanie
name: Brück, Jürgen
name: Holstein, Julia
name: Schäfer, Iris
name: Solimani, Farzan
name: Handgretinger, Rupert
name: Hartl, Dominik
name: Ghoreschi, Kamran
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: autoimmune skin blistering disease
subject: autoimmunity
subject: desmoglein
subject: MDSC
subject: T helper cells
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells, which are characterized by their capability to suppress T-cell responses. While MDSCs have been traditionally associated with cancer diseases, their role as regulators of autoimmune diseases is emerging. Pemphigus is a chronic autoimmune blistering skin disease characterized by dysregulated T-cell responses and autoantibody production. The role of MDSCs in pemphigus disease has not been defined yet. The aim of this study was to characterize MDSCs in pemphigus patients and to dissect their relationship with CD4(+) T-cell subsets and clinical disease assessments. For this purpose, we performed a cross-sectional analysis of 20 patients with pemphigus. Our results indicate that a population of CD66b(+)CD11b(+) polymorphonuclear-like MDSCs (PMN-MDSCs) is expanded in the peripheral blood mononuclear cell fraction of pemphigus patients compared to age-matched healthy donors. These PMN-MDSCs have the capability of suppressing allogeneic T-cell proliferation in vitro and show increased expression of characteristic effector molecules such as arginase I and interleukin-10. We further demonstrate that PMN-MDSCs are especially expanded in patients with active pemphigus, but not in patients in remission. Moreover, MDSC frequencies correlate with an increased Th2/Th1 cell ratio. In conclusion, the identification of a functional PMN-MDSC population suggests a possible role of these cells as regulators of Th cell responses in pemphigus.