cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantum entanglement in a four-partite hybrid system containing three macroscopic subsystems
Creators: name: Corrêa, C.
name: Vidiella-Barranco, A.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The combination of different quantum systems may allow the exploration of the distinctive features of each system for the investigation of fundamental phenomena as well as for quantum technologies. In this work we consider a setup consisting of an atomic ensemble enclosed within a laser-driven optomechanical cavity, having the moving mirror further (capacitively) coupled to a low frequency LC circuit. This constitutes a four-partite optoelectromechanical quantum system containing three macroscopic quantum subsystems of a different nature, viz, the atomic ensemble, the massive mirror and the LC circuit. The quantized cavity field plays the role of an auxiliary system that allows the coupling of two other quantum subsystems. We show that for experimentally achievable parameters, it is possible to generate steady state bipartite Gaussian entanglement between pairs of macroscopic systems. In particular, we find under which conditions it is possible to obtain a reasonable amount of entanglement between the atomic ensemble and the LC circuit, systems that might be suitable for constituting a quantum memory and for quantum processing, respectively. For complementarity, we discuss the effect of the environmental temperature on quantum entanglement.
description: 16 pages, 5 figures
Borders of a Human Being
Creators: name: Plochberger, Franz
Publisher: name: figshare
Year: 2016
Subjects: subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description:
Informatics in technical reality is coming nearer and nearer to the “biological” human being.
It seems to be necessary to protect humans against excessive demands by hardware of
Cyber world and especially against computers as machines and their software.
The human being as evolutional species on one side is measured in a very long development
time of thousands of years, the IT on the other side works with human creativity and in
much faster time intervals of some years or - maximal - decenniums only. These times show
a big difference in both areas. The execution-times of the biological human being and his
general surroundings on one hand and the IT with her applications – in electronic speeds -
on the other hand are an outstanding conflict of time. Humans don’t act like computers!
The structure of this work is given by the biological organism, but also the thinking and
feeling of a human being. He has senses, instruments for movement and mental abilities as a
whole. The human being in nature science is a biological object and in the human society an
individual subject with own self awareness und personal intelligence. Compared with all living
subjects he has the highest developed consciousness of his own person. The modern science
seems to make them unimportant.
The goal of this work is, to find the biological a n d psychological borders of the human
being and protect him in a preventive medical kind against coming dangers like for inst. bad
stress and following sickness. Theoretical Informatics has to find out principles, rules and
ways of thinking for human-orientated IT to avoid this danger.
There is no demand on finding out all at once but a beginning on a scientific level is intended.
This work is thought as the first foundation and compendium for all main themes of HO
(Human Orientation).
Besides a speciality out of biology is described new - The Rules of Mendel, a biological
stimulus for informatics.
Additional file 2: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Creators: name: Billin, Andrew
name: Honeycutt, Samuel
name: McDougal, Alan
name: Kerr, Jaclyn
name: Chen, Zhe
name: Freudenberg, Johannes
name: Rajpal, Deepak
name: Luo, Guizhen
name: Kramer, Henning
name: Geske, Robert
name: Fang, Frank
name: Yao, Bert
name: Clark, Richard
name: Lepore, John
name: Cobitz, Alex
name: Miller, Ram
name: Nosaka, Kazunori
name: Hinken, Aaron
name: Russell, Alan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Figure S2. Prolyl hydroxylase inhibitors do not alter transcriptional profiles in skeletal muscle. (a) Transcriptional profile in mouse gastrocnemius muscle 9 h after injury with 10 mg/kg GSK360 or vehicle. After correcting for multiple testing, no statistically significant changes were detected. (b) Relative tissue concentration of GSK360 after 4 h of IV infusion (n = 3). (c) Flow cytometry quantification of F4/80 positive macrophages in muscle 0–14 days after muscle injury with 10 mg/kg GSK360 or vehicle (n = 4). (d) Quantification of HIF1α in polarized murine bone marrow-derived macrophages (BMDM) following 24 h of GSK360 treatment. Protein extracts from BMDMs were generated (n = 2). HIF1α was quantified via DuoSet ELISA (R&D Systems) with protein extracts. All data in the figure are shown as the mean ± SEM. Two-way ANOVA followed by Holm-Sidak’s test corrected for multiple comparisons; **P < 0.01 as compared to vehicle dosed cohort. (PDF 257 kb)
Effects of dried tomato waste powder levels on lycopene content,lipid oxidation, color, antioxidant activity, and sensory properties offrankfurter sausage made from Thai native beef
Creators: name: Sarong So
name: Suthipong Uriyapongson
name: Juntanee Uriyapongson
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2020
Subjects: tomato
antioxidant
lycopene content
color
sensory property

description: Songklanakarin Journal of Science and Technology, 42, 1, 27-34
Borders of Human Being
Creators: name: Plochberger, Franz
Publisher: name: figshare
Year: 2016
Subjects: subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description:
Informatics in technical reality is coming nearer and nearer to the “biological” human being.
It seems to be necessary to protect humans against excessive demands by hardware of
Cyber world and especially against computers as machines and their software.
The human being as evolutional species on one side is measured in a very long development
time of thousands of years, the IT on the other side works with human creativity and in
much faster time intervals of some years or - maximal - decenniums only. These times show
a big difference in both areas. The execution-times of the biological human being and his
general surroundings on one hand and the IT with her applications – in electronic speeds -
on the other hand are an outstanding conflict of time. Humans don’t act like computers!
The structure of this work is given by the biological organism, but also the thinking and
feeling of a human being. He has senses, instruments for movement and mental abilities as a
whole. The human being in nature science is a biological object and in the human society an
individual subject with own self awareness und personal intelligence. Compared with all living
subjects he has the highest developed consciousness of his own person. The modern science
seems to make them unimportant.
The goal of this work is, to find the biological a n d psychological borders of the human
being and protect him in a preventive medical kind against coming dangers like for inst. bad
stress and following sickness. Theoretical Informatics has to find out principles, rules and
ways of thinking for human-orientated IT to avoid this danger.
There is no demand on finding out all at once but a beginning on a scientific level is intended.
This work is thought as the first foundation and compendium for all main themes of HO
(Human Orientation).
Besides a speciality out of biology is described new - The Rules of Mendel, a biological
stimulus for informatics.
Effects of black cumin seed cake on qualityand mineral value of steamed cutlets
Creators: name: Naumova, Natalia
name: Lukin, Aleksandr
name: Reshetnik, Ekaterina
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2020
Subjects: cutlets
black cumin seed cake
mineral value

description: Songklanakarin Journal of Science and Technology, 42, 1, 15-20
Duals of Feynman Integrals, 2: Generalized Unitarity
Creators: name: Caron-Huot, Simon
name: Pokraka, Andrzej
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The first paper of this series introduced objects (elements of twisted relative cohomology) that are Poincaré dual to Feynman integrals. We show how to use the pairing between these spaces -- an algebraic invariant called the intersection number -- to express a scattering amplitude over a minimal basis of integrals, bypassing the generation of integration-by-parts identities. The initial information is the integrand on cuts of various topologies, computable as products of on-shell trees, providing a systematic approach to generalized unitarity. We give two algorithms for computing the multi-variate intersection number. As a first example, we compute 4- and 5-point gluon amplitudes in generic spacetime dimension. We also examine the 4-dimensional limit of our formalism and provide prescriptions for extracting rational terms.
description: 51+8 pages, 7 figures, 4 ancillary files; updated to match version published in JHEP
Enlarged Kuramoto Model: Secondary Instability and Transition to Collective Chaos
Creators: name: León, Iván
name: Pazó, Diego
Publisher: name: arXiv
Year: 2021
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: The emergence of collective synchrony from an incoherent state is a phenomenon essentially described by the Kuramoto model. This canonical model was derived perturbatively, by applying phase reduction to an ensemble of heterogeneous, globally coupled Stuart-Landau oscillators. This derivation neglects nonlinearities in the coupling constant. We show here that a comprehensive analysis requires extending the Kuramoto model up to quadratic order. This "enlarged Kuramoto model" comprises three-body (nonpairwise) interactions, which induce strikingly complex phenomenology at certain parameter values. As the coupling is increased, a secondary instability renders the synchronized state unstable, and subsequent bifurcations lead to collective chaos. An efficient numerical study of the thermodynamic limit, valid for Gaussian heterogeneity, is carried out by means of a Fourier-Hermite decomposition of the oscillator density.
description: 12 pages, 4 figures
Testing Sulforaphane for chemoprevention against ageing and functional decline in male Drosophila models
Creators: name: Bellew-Dunn, Esme
Publisher: name: Lancaster University
Year: 2020
Subjects: Sulforaphane
Ageing
Drosophila melanogaster
DROSOPHILA

description: Sulforaphane (SFN) has been a phytochemical of interest in targeting several diseases. Many of these diseases are age related. Further, we can find evidence in the literature that SFN affects nearly every understood hallmark of ageing. Despite this, very little work has been carried out with SFN in the context of ageing, lifespan and functional health with age. Previous unpublished work has supported the possibility that SFN acts as a hormetic drug to improve lifespan at sub-toxic doses. In this study, SFN was tested in the Drosophila melanogaster model organism, and its effects in lifespan, performance and biochemical hallmarks of ageing were monitored. These were assessed through three full lifespan/survival studies, a negative geotaxis assay, and a quantitative Real-Time Polymerase Chain Reaction experiment to investigate the impact of the drug on antioxidant gene expression. A High-Performance Liquid Chromatography experiment was also carried out to investigate our early findings, and test SFN absorption into fly food. A significant improvement in lifespan was associated with SFN in only very limited conditions. White Dahomey flies reared on sugar-yeast food given 100µg/ml SFN between days 9 and 45 of their lives showed an improvement of 5.74%. Notably, Lancaster flies under identical conditions showed a significant decline (6.34%). No other significant findings were made. These findings may indicate SFN has limited potential as an anti-ageing intervention and its effect is dramatically altered by food conditions, genetic background, and timing of dosage. However, we cannot rule out that these findings were caused by chance, and so recommend further work to verify our findings. We also hypothesise that another compound found in broccoli extract, glucoraphanin, may represent a better target for these studies, as previous work has shown low-SFN content broccoli extract to have a stronger effect than pure SFN.
Dissipation Inequality and Parameter values from A continuum model for the growth of dendritic actin networks
Creators: name: Abeyaratne, Rohan
name: Purohit, Prashant K.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Biophysics
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Polymerization of dendritic actin networks underlies important mechanical processes in cell biology such as the protrusion of lamellipodia, propulsion of growth cones in dendrites of neurons, intracellular transport of organelles and pathogens, among others. The forces required for these mechanical functions have been deduced from mechano-chemical models of actin polymerization; most models are focused on single growing filaments, and only a few address polymerization of filament networks through simulations. Here, we propose a continuum model of surface growth and filament nucleation to describe polymerization of dendritic actin networks. The model describes growth and elasticity in terms of macroscopic stresses, strains and filament density rather than focusing on individual filaments. The microscopic processes underlying polymerization are subsumed into kinetic laws characterizing the change of filament density and the propagation of growing surfaces. This continuum model can predict the evolution of actin networks in disparate experiments. A key conclusion of the analysis is that existing laws relating force to polymerization speed of single filaments cannot predict the response of growing networks. Therefore, a new kinetic law, consistent with the dissipation inequality, is proposed to capture the evolution of dendritic actin networks under different loading conditions. This model may be extended to other settings involving a more complex interplay between mechanical stresses and polymerization kinetics, such as the growth of networks of microtubules, collagen filaments, intermediate filaments and carbon nanotubes.
Antimicrobial activity of prodigiosin is attributable to plasma-membrane damage
Creators: name: Suryawanshi, Rahul K.
name: Chandrashekhar D. Patil
name: Koli, Sunil H.
name: Hallsworth, John E.
name: Patil, Satish V.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The bacterial pigment prodigiosin has various biological activities; it is, for instance, an effective antimicrobial. Here, we investigate the primary site targeted by prodigiosin, using the cells of microbial pathogens of humans as model systems: Candida albicans, Escherichia coli, Staphylococcus aureus. Inhibitory concentrations of prodigiosin; leakage of intracellular K+ ions, amino acids, proteins and sugars; impacts on activities of proteases, catalases and oxidases; and changes in surface appearance of pathogen cells were determined. Prodigiosin was highly inhibitory (30% growth rate reduction of C. albicans, E. coli, S. aureus at 0.3, 100 and 0.18 μg ml−1, respectively); caused leakage of intracellular substances (most severe in S. aureus); was highly inhibitory to each enzyme; and caused changes to S. aureus indicative of cell-surface damage. Collectively, these findings suggest that prodigiosin, log Poctanol–water 5.16, is not a toxin but is a hydrophobic stressor able to disrupt the plasma membrane via a chaotropicity-mediated mode-of-action.
LHC Lifetime Frontier and Visible Decay Searches in Composite Asymmetric Dark Matter Models
Creators: name: Kamada, Ayuki
name: Kuwahara, Takumi
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The LHC lifetime frontier will probe dark sector in near future, and the visible decay searches at fixed-target experiments have been exploring dark sector. Composite asymmetric dark matter with dark photon portal is a promising framework explaining the coincidence problem between dark matter and visible matter. Dark strong dynamics provides rich structure in the dark sector: the lightest dark nucleon is the dark matter, while strong annihilation into dark pions depletes the symmetric components of the dark matter. Dark photons alleviate cosmological problems. Meanwhile, dark photons make dark hadrons long-lived in terrestrial experiments. Moreover, the dark hadrons are produced through the very same dark photon. In this study, we discuss the visible decay searches for composite asymmetric dark matter models. For a few GeV dark nucleons, the LHC lifetime frontier, MATHUSLA and FASER, has a potential to discover their decay when kinetic mixing angle of dark photon is $ε\gtrsim 10^{-4}$. On the other hand, fixed-target experiments, in particular SeaQuest, will have a great sensitivity to dark pions with a mass below GeV and with kinetic mixing $ε\gtrsim 10^{-4}$ in addition to the LHC lifetime frontier. These projected sensitivities to dark hadrons in dark photon parameter space are comparable with the future sensitivities of dark photon searches, such as Belle-II and LHCb.
description: 37+37 pages, 6+6 figures; discussions improved, figures modified, version published in JHEP
title: Tableau référençant les articles de presse entre 1975 et 1999 dans les archives Leibowitch
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-2019311113569663
description: created: start=1975;end=2018
Quantitative projection of human brain penetration of the H3 antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancy
Creators: name: Sawant-Basak, Aarti
name: Laigao Chen
name: Shaffer, Christopher L.
name: Palumbo, Donna
name: Schmidt, Anne
name: Tseng, Elaine
name: Spracklin, Douglas K.
name: Jean-Dominique Gallezot
name: Labaree, David
name: Nabulsi, Nabeel
name: Yiyun Huang
name: Carson, Richard E.
name: McCarthy, Timothy
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: 1. Unbound brain drug concentration (Cb,u), a valid surrogate of interstitial fluid drug concentration (CISF), cannot be directly determined in humans, which limits accurately defining the human Cb,u:Cp,u of investigational molecules. 2. For the H3R antagonist (1R,3R)-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-lmethyl)phenyl]cyclobutane-1-carboxamide (PF-03654746), we interrogated Cb,u:Cp,u in humans and nonhuman primate (NHP). 3. In rat, PF-03654746 achieved net blood–brain barrier (BBB) equilibrium (Cb,u:Cp,u of 2.11). 4. In NHP and humans, the PET receptor occupancy-based Cp,u IC50 of PF-03654746 was 0.99 nM and 0.31 nM, respectively, which were 2.1- and 7.4-fold lower than its in vitro human H3 Ki (2.3 nM). 5. In an attempt to understand this higher-than-expected potency in humans and NHP, rat-derived Cb,u:Cp,u of PF-03654746 was integrated with Cp,u IC50 to identify unbound (neuro) potency of PF-03654746, nIC50. 6. The nIC50 of PF-03654746 was 2.1 nM in NHP and 0.66 nM in human which better correlated (1.1- and 3.49-fold lower) with in vitro human H3 Ki (2.3 nM). 7. This correlation of the nIC50 and in vitro hH3 Ki suggested the translation of net BBB equilibrium of PF-03654746 from rat to NHP and humans, and confirmed the use of Cp,u as a reliable surrogate of Cb,u. 8. Thus, nIC50 quantitatively informed the human Cb,u:Cp,u of PF-03654746.
IN03150 Galle Trilingual Slab - Tamil Inscription
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03150
Epigraphia Zeylanica
Galle Trilingual Slab

description: IN03150 Galle Trilingual Slab - Tamil Inscription - Transcript and Translation Source: Paranavitana, S., with an appendix by H. W. Codrington. (1928-33). ‘No. 36. The Tamil Inscription on the Galle Trilingual Slab,’ Epigraphia Zeylanica 3, pp. 331–341.
Additional file 1: of A perioperative surgeon-controlled open-lung approach versus conventional protective ventilation with low positive end-expiratory pressure in cardiac surgery with cardiopulmonary bypass (PROVECS): study protocol for a randomized controlled trial
Creators: name: Lagier, David
name: Fischer, François
name: Fornier, William
name: Fellahi, Jean-Luc
name: Colson, Pascal
name: Cholley, Bernard
name: Jaber, Samir
name: Baumstarck, Karine
name: Guidon, Catherine
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Medicine
Developmental Biology

description: PROVECS study protocol (most recent version). (DOCX 330 kb)
An elementary proof of Takagi's theorem on the differential composition of polynomials
Creators: name: Sokal, Alan D.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30C15 (Primary), 30C10 (Secondary)

description: I give a short and completely elementary proof of Takagi's 1921 theorem on the zeros of a composite polynomial $f(d/dz) \, g(z)$.
description: LaTeX2e, 4 pages. Accepted for publication in the American Mathematical Monthly
Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents
Creators: name: Zagórska, Agnieszka
name: Bucki, Adam
name: Kołaczkowski, Marcin
name: Siwek, Agata
name: Głuch-Lutwin, Monika
name: Starowicz, Gabriela
name: Kazek, Grzegorz
name: Partyka, Anna
name: Wesołowska, Anna
name: Słoczyńska, Karolina
name: Elżbieta Pękala
name: Pawłowski, Maciej
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A series of 2-fluoro and 3-trifluoromethylphenylpiperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (4–21) were synthesized and evaluated for their serotonin (5-HT1A/5-HT7) receptor affinity and phosphodiesterase (PDE4B and PDE10A) inhibitor activity. The study enabled the identification of potent 5-HT1A, 5-HT7 and mixed 5-HT1A/5-HT7 receptor ligands with weak inhibitory potencies for PDE4B and PDE10A. The tests have been completed with the determination of lipophilicity and metabolic stability using micellar electrokinetic chromatography (MEKC) system and human liver microsomes (HLM) model. In preliminary pharmacological in vivo studies, selected compound 8-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-1,3,7-trimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (9) behaved as a potential antidepressant in forced swim test (FST) in mice. Moreover, potency of antianxiety effects evoked by 9 (2.5 mg/kg) is greater than that of the reference anxiolytic drug, diazepam. Molecular modeling revealed that fluorinated arylpiperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione have major significance for the provision of lead compounds for antidepressant and/or anxiolytic application.
Additional file 4: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Creators: name: Billin, Andrew
name: Honeycutt, Samuel
name: McDougal, Alan
name: Kerr, Jaclyn
name: Chen, Zhe
name: Freudenberg, Johannes
name: Rajpal, Deepak
name: Luo, Guizhen
name: Kramer, Henning
name: Geske, Robert
name: Fang, Frank
name: Yao, Bert
name: Clark, Richard
name: Lepore, John
name: Cobitz, Alex
name: Miller, Ram
name: Nosaka, Kazunori
name: Hinken, Aaron
name: Russell, Alan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: Figure S3. Daprodustat does not alter arm range of motion after eccentric exercise. (a) Effect of different daily doses of daprodustat on contraction induced injury in mice. Mice were treated with vehicle or the indicated dose of daprodustat daily. Data are normalized to pre-damage force (n = 9). (b) Arm range of motion, measured with a manual goniometer was recorded 10 min pre-exercise and 5 min, 30 min, 24 h, 48 h, and 72 h post exercise. The boxed area represents a 75% range of values with the central line indicating the median and the cross the mean value. Individual values are displayed to the left (top panel placebo vs GSK863 5 mg (n = 14, n = 12), bottom panel placebo vs GSK863 50 mg (both n = 15)). (PDF 270 kb)
Thermodynamics of spacetime and unimodular gravity
Creators: name: Alonso-Serrano, Ana
name: Liška, Marek
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this review we discuss emergence of unimodular gravity (or, more precisely, Weyl transverse gravity) from thermodynamics of spacetime. By analyzing three different ways to obtain gravitational equations of motion by thermodynamic arguments, we show that the results point to unimodular rather than fully diffeomorphism invariant theories and that this is true even for modified gravity. The unimodular character of dynamics is especially evident from the status of cosmological constant and energy-momentum conservation.
description: 19 pages, 2 figures. Review prepared for a Special Issue of the International Journal of Geometric Methods in Modern Physics dedicated to the conference Geometric Foundations of Gravity 2021. Version accepted by IJGMMP
Strain gradient development in 3-dimensional extracellular matrix scaffolds during in vitro mechanical stimulation
Creators: name: Seifer, Benjamin J.
name: Wagner, Christopher T.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: This study analyzed strain variations in 3D ECM scaffolds using a membrane-adherent model (MM) and a direct elongation model (DM). Computational models were solved for target strains from 1 to 10% at varied scaffold thicknesses and intra-scaffold slices. DM strain profiles were uniform within the scaffold and independent of thickness. However, a wide range of strains developed with substantial volume experiencing significantly off-target strain. MM strain profiles varied throughout the scaffold, exhibiting significantly reduced average strain with increasing thickness. These findings are important for tissue engineering studies since biological responses are commonly attributed to a single strain level that only partially describes the mechanical condition, making it difficult to develop precise causal relationships. Spatial strain variations and reduced average strain may warrant targeted sampling for cell response and should be taken into consideration by investigators using large-volume 3D scaffolds when engineering mechanically sensitive tissues.
Excitonic insulators and Gross-Neveu models
Creators: name: Lopes, Nei
name: Continentino, Mucio A.
name: Barci, Daniel G.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We introduce a generalized Gross-Neveu (GN) model to describe the excitonic instabilities in two different systems: a small overlap semi-metal (SM) and a small gap semi-conductor (SMC), both in two (2d) and three-dimensions (3d). We identify the excitonic order parameter (EOP) and obtain the effective potential within the Large $N$ limit approach where the GN model can be exactly solved. We obtain the excitonic insulator (EI) phase diagrams as a function of temperature, chemical potential, overlap between bands and gaps of the system. We show that the EI may undergo first- or second-order thermal transitions depending on the regime whereupon this phase is approached. We also investigate the expected thermodynamic signatures for the specific heat above the fine-tuned excitonic quantum critical point (EQCP), in both 2d and 3d, in the SMC regime. We show that the EQCP is a different kind of critical point since although the EOP vanishes at the EQCP, there is always a finite gap in the SMC regime. We find that for high temperatures, the specific heat might exhibit a scaling behavior in the form $C_V/T \propto T^{(d-z)/z}$, where $d$ is the dimension of the system and $z$ is the dynamical critical exponent. The very low temperature behavior has a dominant exponential thermally activated term due to the presence of a gap that does not vanish at the excitonic transition.
description: 12 pages and 17 figures
OB03125 Galle Trilingual Slab
Creators: name: Perera, E. W.
Publisher: name: Zenodo
Year: 2020
Subjects: OB03125
Galle Trilingual Slab
Spolia Zeylanica

description: OB03125 Galle Trilingual Slab - Image Source: Perera, E. W. (1913). ‘The Galle Trilingual Slab.’ Spolia Zeylanica 8, plate 1, opposite p. 132.
Remote sensing of invasive plants: incorporating functional traits into the picture
Creators: name: Madhura Niphadkar
name: Harini Nagendra
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Science Policy
subject: Plant Biology

description: Invasive plant species spread presents a challenge, requiring better mapping and monitoring for control. Remote sensing (RS) provides an efficient tool to map invasive plants in diverse ecosystems. Yet applications of RS for invasive plant mapping largely rely on spatial and spectral patterns. The use of invasive plant functional traits can improve RS mapping, using ecological insights on processes and functions associated with invasion. We summarize research utilizing plant functional traits in RS mapping of invasive species from the years 2000 to 2014. Based on this review, we summarize plant traits that can be related to spatial and spectral properties, and used to discriminate invasive alien plants from native vegetation. Phenological and structural plant traits have been relatively well exploited via RS for invasion studies. In comparison, there has been limited utilization of physiological traits (with the exception of properties such as nitrogen content). This is an area that merits further research attention, via the linkage of ecophysiological field research with RS.
Additional file 2: of A perioperative surgeon-controlled open-lung approach versus conventional protective ventilation with low positive end-expiratory pressure in cardiac surgery with cardiopulmonary bypass (PROVECS): study protocol for a randomized controlled trial
Creators: name: Lagier, David
name: Fischer, François
name: Fornier, William
name: Fellahi, Jean-Luc
name: Colson, Pascal
name: Cholley, Bernard
name: Jaber, Samir
name: Baumstarck, Karine
name: Guidon, Catherine
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Cancer
Science Policy

description: Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist. (DOC 120 kb)
Performance comparison of computational ghost imaging versus single-pixel camera in light disturbance environment
Creators: name: Gong, Wenlin
Publisher: name: arXiv
Year: 2021
Subjects: subject: Image and Video Processing (eess.IV)
subject: Optics (physics.optics)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Physical sciences

description: Computational ghost imaging (CGI) and single-pixel camera (SPC) are two types of single-pixel imaging and attracts increasing interest in recent years. The performance differences of CGI and SPC in difference light disturbance environment are investigated. In comparison with CGI, we demonstrate that the quality of SPC is always better in the same conditions and local light disturbance has a larger influence to CGI/SPC than global light disturbance. In addition, a method to improve the reconstruction result of SPC is proposed if the source's energy is unstable and there is light disturbance in the detection process, and its validity is also verified by numerical simulation.
The constitution of electricity demand in Central Manchester: practices, infrastructure and spaces
Creators: name: Holmes, Torik
Publisher: name: Lancaster University
Year: 2019

description: Energy demand has been conceptualised and studied as an outcome of the organisation and performance of social practices and of relationships between practices and infrastructures. Detail regarding the spatial features of these relationships remains underdeveloped. This thesis focuses on the shifting sites of electricity provision and demand, as these relate to changes in the mixture of residential and commercial activity in Central Manchester from 1984 to present. The thesis consists of four linked studies, each designed to provide new insights into the spatial organisation of electricity provision and consumption. The first shows how patterns of electricity demand and land use change together within the centre of the city over time. The second shows that these developments relate to and reflect events and trends that extend beyond the city. The third study follows the construction of one critical part of Central Manchester’s electricity infrastructure and the fourth shows this to be an outcome of relations that again extend well beyond the city itself. These studies, based on expert interviews and secondary data, including maps, schematic diagrams and official plans and strategies, move between scales and between aspects of provision and consumption to provide a subtle and complex account of how practices and infrastructures shape each other across scale. Together, these studies reveal changing relationships between practices and the electricity network at different geographical scales and provide new insight into the emergence and types of ‘global-local’ flows, thresholds, and critical moments that characterise the constitution and the dynamics of electricity demand over time.
D3PG: Dirichlet DDPG for Task Partitioning and Offloading with Constrained Hybrid Action Space in Mobile Edge Computing
Creators: name: Ale, Laha
name: King, Scott A.
name: Zhang, Ning
name: Sattar, Abdul Rahman
name: Skandaraniyam, Janahan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Mobile Edge Computing (MEC) has been regarded as a promising paradigm to reduce service latency for data processing in the Internet of Things, by provisioning computing resources at the network edge. In this work, we jointly optimize the task partitioning and computational power allocation for computation offloading in a dynamic environment with multiple IoT devices and multiple edge servers. We formulate the problem as a Markov decision process with constrained hybrid action space, which cannot be well handled by existing deep reinforcement learning (DRL) algorithms. Therefore, we develop a novel Deep Reinforcement Learning called Dirichlet Deep Deterministic Policy Gradient (D3PG), which is built on Deep Deterministic Policy Gradient (DDPG) to solve the problem. The developed model can learn to solve multi-objective optimization, including maximizing the number of tasks processed before expiration and minimizing the energy cost and service latency.} More importantly, D3PG can effectively deal with constrained distribution-continuous hybrid action space, where the distribution variables are for the task partitioning and offloading, while the continuous variables are for computational frequency control. Moreover, the D3PG can address many similar issues in MEC and general reinforcement learning problems. Extensive simulation results show that the proposed D3PG outperforms the state-of-art methods.
Path-entangling evolution and quantum gravitational interaction
Creators: name: Matsumura, Akira
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We explore a general feature of the interaction mediated by the gravitational fields of spatially superposed masses. For this purpose, based on quantum information theory, we characterize the evolution of two particles each in a superposition state of paths. The evolution is assumed to be given by a completely positive trace-preserving (CPTP) map. We further assume that the probability of particle being on each path is unchanged during the evolution. This property is called population-preserving. We examine when a population-preserving CPTP map can create entanglement in terms of separable operations, which form a large class of local operations and classical communication (LOCC). In general, entanglement is not always generated by inseparable or non-LOCC operations, and one can consider a model of gravity described by an inseparable operation which does not create entanglement. However, we find that a population-preserving CPTP map is inseparable if and only if it can create entanglement. This means that the above model of gravity is incompatible with the possible evolution of spatially superposed masses.
description: 21 pages, 4 figures
Selection of a network of large lakes and reservoirs suitable for global environmental change analysis using Earth Observation
Creators: name: E. Politi
name: S. MacCallum
name: M.E.J. Cutler
name: C.J. Merchant
name: J.S. Rowan
name: T.P. Dawson
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The GloboLakes project, a global observatory of lake responses to environmental change, aims to exploit current satellite missions and long remote-sensing archives to synoptically study multiple lake ecosystems, assess their current condition, reconstruct past trends to system trajectories, and assess lake sensitivity to multiple drivers of change. Here we describe the selection protocol for including lakes in the global observatory based upon remote-sensing techniques and an initial pool of the largest 3721 lakes and reservoirs in the world, as listed in the Global Lakes and Wetlands Database. An 18-year-long archive of satellite data was used to create spatial and temporal filters for the identification of waterbodies that are appropriate for remote-sensing methods. Further criteria were applied and tested to ensure the candidate sites span a wide range of ecological settings and characteristics; a total 960 lakes, lagoons, and reservoirs were selected. The methodology proposed here is applicable to new generation satellites, such as the European Space Agency Sentinel-series.
Additional file 5: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Creators: name: Billin, Andrew
name: Honeycutt, Samuel
name: McDougal, Alan
name: Kerr, Jaclyn
name: Chen, Zhe
name: Freudenberg, Johannes
name: Rajpal, Deepak
name: Luo, Guizhen
name: Kramer, Henning
name: Geske, Robert
name: Fang, Frank
name: Yao, Bert
name: Clark, Richard
name: Lepore, John
name: Cobitz, Alex
name: Miller, Ram
name: Nosaka, Kazunori
name: Hinken, Aaron
name: Russell, Alan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health

description: Table S2. Demographic data for the two healthy volunteer studies. Twenty-six healthy volunteers were randomized in Cohort 1, 30 were randomized in cohort 2, with approximately 1:1 ratio of daprodustat vs. placebo. All randomized subjects completed the study, and the data from all randomized subjects were included in the study analyses. Overall, demographic characteristics were similar among the placebo and GSK127863 groups. No violation of the treatment assignment or broken blinding occurred in this study. No significant protocol deviations were found during the study. (PDF 200 kb)
Electromagnetic Signatures from Supermassive Binary Black Holes Approaching Merger
Creators: name: Gutiérrez, Eduardo M.
name: Combi, Luciano
name: Noble, Scott C.
name: Campanelli, Manuela
name: Krolik, Julian H.
name: Armengol, Federico G. López
name: García, Federico
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present fully relativistic predictions for the electromagnetic emission produced by accretion disks surrounding spinning and nonspinning supermassive binary black holes on the verge of merging. We use the code Bothros to post-process data from 3D general relativistic magnetohydrodynamic simulations via ray-tracing calculations. These simulations model the dynamics of a circumbinary disk and the mini-disks that form around two equal-mass black holes orbiting each other at an initial separation of 20 gravitational radii, and evolve the system for more than 10 orbits in the inspiral regime. We model the emission as the sum of thermal blackbody radiation emitted by an optically thick accretion disk and a power-law spectrum extending to hard X-rays emitted by a hot optically thin corona. We generate time-dependent spectra, images, and light curves at various frequencies to investigate intrinsic periodic signals in the emission, as well as the effects of the black hole spin. We find that prograde black hole spin makes mini-disks brighter since the smaller innermost stable circular orbit angular momentum demands more dissipation before matter plunges to the horizon. However, compared to mini-disks in larger separation binaries with spinning black holes, our mini-disks are less luminous: unlike those systems, their mass accretion rate is lower than in the circumbinary disk, and they radiate with lower efficiency because their inflow times are shorter. Compared to a single black hole system matched in mass and accretion rate, these binaries have spectra noticeably weaker and softer in the UV. Finally, we discuss the implications of our findings for the potential observability of these systems.
description: 19 pages, 15 figures; matching published version except for a clarification in Sec. 4.3
Additional file 1: of Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
Creators: name: Zhang, Ze-Yu
name: Liu, Zhe
name: Deng, Hui-Hui
name: Chen, Qin
Publisher: name: figshare
Year: 2018
Subjects: Biological Sciences not elsewhere classified
Developmental Biology
Science Policy

description: PRISMA 2009 Checklist. (DOC 57 kb)
ANOTACIONES SOBRE ASPECTOS FLORÍSTICOS DE LAS ÁREAS VERDES DE LA PARROQUIA URBANA CHIQUINQUIRA, MUNICIPIO MARACAIBO, ESTADO ZULIA, VENEZUELA
Creators: name: Villalobos, José Alberto Soto
name: Diaz, Javier
name: Ramírez, Maribel
Publisher: name: figshare
Year: 2016
Subjects: Botany

description: Esta información la presentamos en la LXII Convención Anual de AsoVAC, en Caracas, 18-23 de noviembre de 2012.
ANOTACIONES SOBRE ASPECTOS FLORÍSTICOS DE LAS ÁREAS VERDES DE LA PARROQUIA URBANA CHIQUINQUIRA, MUNICIPIO MARACAIBO, ESTADO ZULIA, VENEZUELA
Creators: name: Villalobos, José Alberto Soto
name: Diaz, Javier
name: Ramírez, Maribel
Publisher: name: figshare
Year: 2016
Subjects: Botany

description: En esta publicación (resumen) registramos algunos apuntes preliminares sobres los aspectos florísticos de las áreas verdes de la parroquia Urbana Chiquinquira, municipio Maracaibo, estado Zulia.
Esta información la presentamos en la LXII Convención Anual de AsoVAC, en Caracas, 18-23 de noviembre de 2012.
Additional file 6: of HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Creators: name: Billin, Andrew
name: Honeycutt, Samuel
name: McDougal, Alan
name: Kerr, Jaclyn
name: Chen, Zhe
name: Freudenberg, Johannes
name: Rajpal, Deepak
name: Luo, Guizhen
name: Kramer, Henning
name: Geske, Robert
name: Fang, Frank
name: Yao, Bert
name: Clark, Richard
name: Lepore, John
name: Cobitz, Alex
name: Miller, Ram
name: Nosaka, Kazunori
name: Hinken, Aaron
name: Russell, Alan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Table S3. Summary of adverse events. No serious adverse events (SAEs) were reported in this study. Fifteen subjects (26.8%) reported adverse events (AEs). The most commonly reported AEs (>â 1 subject) were myalgia in nine subjects (16.1%), headache in two subjects (3.6%), and peripheral swelling in two subjects (3.6%). Myalgia was largely limited to arm pain during and after the exercise. Single events of vomiting and pollakiuria, both in the placebo group, were not considered by the investigator as related to study drug. No AEs led to withdrawal of subjects from this study. There were no clinically significant findings of vital signs, ECG or clinical laboratory parameters. (PDF 196 kb)