cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Olivierus martensii
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Buthidae
Olivierus
Olivierus martensii

description: (2) Olivierus martensii (Karsch, 1879)
TYPE LOCALITY AND TYPE DEPOSITORY. “ Singapore ”; ZMHB.
PROTONYM. Buthus martensii Karsch, 1879.
SYNONYM. Buthus confucius Simon, 1880 (●).
CHINESE EQUIVALENT. ¼氏Dz氏x.
DISTRIBUTION (○). Anhui; Beijing; Fujian; Hebei; Henan; Hubei; Inner Mongolia; Jiangsu; Liaoning; Ningxia; Qinghai; Shaanxi; Shandong; Shanxi; Sichuan; Tianjin.
REMARKS. Buthus martensii hainanensis Birula, 1904 (●) is presumably a junior synonym of this species (Tang et al., 2024a: 19).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 15, DOI: 10.5281/zenodo.14660932
Developing systems-based methodologies for constructing context-specific versions of the Bcr-Abl and Src signaling network
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Towards the goal of developing system-wide views of signaling in Bcr-Abl-driven leukemias, we are developing phosphoprofiling-based approaches to determining the structure of the Bcr-Abl signaling network. While our ultimate goal is a systems view, we have begun by focusing on the subnetwork proximal to Bcr-Abl and Src family kinases (SFKs). While many signaling pathways have been defined in the literature, the compiled results typically come from multiple biological systems (e.g. different tissue types or lineages). Thus, our interests are both in defining SFK signaling in the context of Bcr-Abl-driven leukemia and in the contexts of different blood cell lineages. This proposal continues our preliminary work in inferring the SFK subnetwork structure from measurements of how the network responds to perturbations of SFKs by specific kinase inhibitory drugs or Src kinase overexpression or knock down (Aim 1). For this part of the proposal we are using a global mass spectrometry-based phospho proteomics approach that generically measures tyrosine phosphorylation events using a pan-specific anti-phosphotyrosine antibody in an enrichment step. We also propose here to develop more targeted phospho-profiling approaches that will use specific anti-phospho antibodies in a phospho immunostaining flow cytometry approach (phosphoflow) and multiple reaction monitoring (MRM) mass spectrometry-based phospho proteomics (Aim 2). These targeted approaches will greatly reduce the amount of input material required. Together the global and targeted methods will allow us to define subnetworks with high coverage in a reference system (global approach), and then more efficiently redefine the network in additional cellular contexts (targeted approach). Beyond the scope of this proposal, these advances will allow us to use mouse models to define the Bcr-Abl and Src kinase signaling network in the lineage contexts (lymphoid versus myeloid) where Src kinases have been shown to have distinct contributions to the phenotype of transformation. Ultimately we are searching for a molecular or network-based explanation as to why lymphoid transformation relies on SFKs and myeloid does not. Our approach for generating context-specific signaling networks will be applicable to other cancers, diseases and normal physiology, and our results on lineage-specific leukemia signaling will aid in the development of molecularly targeted therapeutics.
On the Proper Characterization of 'Nonconcatenative' Languages
Creators: name: Gafos, Adamantios
Publisher: name: Garland
Year: 1995

description: Nonconcatenative languages have been claimed to employ a special type of phonological spreading of a consonant over a vowel, which assumes a representation that segregates vowels and consonants on different planes. I argue that this type of spreading can and must be eliminated from the theory, by reducing it to segmental copying as in reduplication. Crucial to this reduction is the notion of gradient violation of constraints in Optimality Theory (Prince & Smolensky 1993), and the notion of Correspondence with its particular application to reduplicative morphology (McCarthy & Prince 1995a). The reduction is demonstrated in detail for Temiar, one of the main indigenous languages of Malaysia, notorious for the complexity of its copying patterns. Extensions of the proposal to Semitic languages are also discussed. Two main theoretical implications of this reduction are then developed. First, the distinction between concatenative and nonconcatenative languages need not and should not be encoded in terms of the special phonological mechanisms of consonantal spreading over a vowel, applying under planar segregation. Second, the locus of the distinction is found to be, instead, in the mode of affixation employed in nonconcatenative languages, namely, a-templatic reduplicative affixation. This type of affixation is predicted, though heretofore undocumented in the typology of word formation.
A small animal model for replication by a human retrovirus implicated in prostate cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In this proposal we will test the hypothesis that the rat is a suitable animal model to study in vivo infection by Xenotropic MuLV-related Virus (XMRV-1), a new human retrovirus that has been implicated in familial human prostate cancer. The tissue tropism and range of cell types infected by XMRV-1 will be investigated. This may provide an animal model to investigate if XMRV-1 participates in human prostate cancer, and it may also provide insight into the cell types that might be infected in vivo. In preliminary results we have established that XMRV-1 can productively infect rat cell lines in culture which raises the possibility that it may be possible to infect rats with the virus as well. This could provide a valuable small animal model for study of XMRV-1. This will be particularly important, since published work suggests that the levels of XMRV-1 in humans with familial prostate cancer, while detectable, is low. In the proposed experiments, we will: 1. Establish a quantitative focal immunofluorescence assay for XMRV-1, as well as other assays for detecting infection. 2. Infect XMRV-1 produced by transient transfection of human 293T cells into rats and determine the tissues and cell types infected. 3. Infect rats with XMRV-1 produced from chronically infected rat NRK cells that shows enhanced infectivity in rat cells. The results of these experiments may establish a small animal model for studying the role of XMRV-1 in prostate carcinogenesis in humans. In future experiments, XMRV-1 infected animals will be monitored for development of prostate cancer or other neoplasias; development of prostate cancer would support an etiologic role in human prostate cancer. Conversely, if other cancers develop, it will be important to survey XMRV-1-infected humans for development of those cancers. Finally, XMRV-1 will be tested for potentiating prostate cancer carcinogenesis in established rat models of prostate cancer.
Didymoglossum rotundifolium (Bonap.) J.P.Roux
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum
Didymoglossum rotundifolium

description: Didymoglossum rotundifolium (Bonap.) J.P.Roux
Didymoglossum rotundifolium (Bonap.) J.P.Roux, Strelitzia 23: 42 (2009). – Trichomanes rotundifolium Bonap., Notes ptéridologiques 9: 23 (1920a). – Type: Madagascar, Massif de Manongarivo, s.d., H.Perrier de la Bâthie 7735 (lectotype, here designated: hololecto-: P00482612!; isolecto-: P00477780!, P00482613!); Madagascar, Massif de Manongarivo, s.d., H.Perrier de la Bâthie 7442 p.p. (syn-: P00482611!).
Short description
Lithophytic or epiphytic; long-creeping filiform rhizomes, rootless and densely covered by dense black trichomes, bearing widely separated pending fronds; fronds sessile to subsessile, up to 0.7(–1) cm long, round to oblong, or ovate, entire with entire to undulate margins, with palmate to slightly pinnate venation, and false veins parallel to true veins in addition to a submarginal false vein; mostly a single terminal sorus per fertile frond, rarely more, and epitactic, campanulate with a slightly dilated mouth.
Global distribution
Madagascar, Comoros.
Distribution in Comoros
Anjouan, Mayotte, Mohéli.
Additional specimens examined
COMOROS: ANJOUAN, s. loc., 1875, J.M.Hildebrandt s.n. (P00347524). MAYOTTE, Massif de Mtsapéré, Maison de la Convalescence, 10 Nov. 2002, F.Rakotondrainibe et al. 6670 (P00311383); Mont Tchaourembo, 13 Nov. 2002, F.Rakotondrainibe et al. 6681 (P00311397). MOHÉLI, Chalet St Antoine, 5 Nov. 2008, M.Pignal et al. 3484 (P00684897).
Note
The sheet P00482612, included in the original material, consists of many individuals with several fertile fronds, and specimens are representative of the morphology of the species. Moreover, this sheet was probably intended to be the holotype, as indicated by the handwritten annotation ‘Original’ by Bonaparte. For all these reasons, P00482612 was selected as the lectotype specimen for T. rotundifolium.
Didymoglossum rotundifolium is the smallest Comorian Hymenophyllaceae species with sessile to subsessile, round to oblong, entire fronds (never lobed contrary to D. erosum), and laminae up to 0.7–1 cm long (see Fig. 2D).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on pages 19-20, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Predicting treatment response of soft tissue sarcomas to neoadjuvant therapy by imaging proliferation with a FLT-PET/CT scan: A pilot study
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Functional imaging has become a promising modality to monitor response to therapy in patients with many malignancies, including high grade soft tissue sarcomas (STS). Although metabolic imaging with F18-fluorodeoxyglucose positron emission tomography (FDG-PET) is significantly more sensitive than current standard size based criteria RECIST (Response Evaluation Criteria in Solid Tumors), its limited specificity considerably restricts its clinical utility as a functional biomarker for assessing treatment response in STS. We hypothesize that imaging proliferation with 18F-fluorodeoxythymidine positron emission tomography (FLT-PET) will provide a more accurate assessment of response to therapy in patients with high grade STS compared to RECIST. We propose three specific aims: 1) To evaluate the ability of FLT-PET to predict histopathologic response to systemic neoadjuvant therapy in patients with resectable high grade STS. We will enroll 30 adult patients to undergo a FLT-PET/CT scan prior to and after neoadjuvant treatment. Relative changes in tumor FLT uptake and size from the baseline to the follow-up scan will be calculated, and their ability to predict histopathologic response will be assessed. 2) To compare the change in tumor FLT uptake and size with histopathologic markers of cellular proliferation, cell cycle progression and apoptosis. 3) To monitor patients for long term outcome measures correlating changes in FLT uptake, size and histopathology with recurrence and survival. We anticipate that this study will improve the treatment of patients with STS by providing a more accurate, non-invasive modality to identify response early in the course of therapy. In addition it will establish a basis by which new targeted therapies can be assessed for response as they become available.
Is French Optimal? A question concerning phonological process order
Creators: name: Noske, Roland
Publisher: name: European Studies Research Institute, University of Salford
Year: 1996

description: In this paper, an analysis is presented of a central part of the phonology of French in the framework of Optimality Theory (OT). It is shown that the facts of the language suggest that the phonological processes at hand should be described as output-driven. Also, the facts suggest that violable constraints should play a central role in the language.Therefore, that the phenomena in question seem ideally suited for an analysis in OT-terms, because of the strong need for two of the principles that define OT. A comprehensive OT analysis of the processes is presented. An output-based analysis predating OT, which treats the schwa-deletion and gliding phenomena of French, is complemented by an analysis ofepenthesis and dierisis phenomena, which were not not covered in the previous analysis. It will become clear, however, that a basic feature of the interaction of the processes collides with one of the defining principles of OT, i.e. the absence of derivation.
Determining the role of Bmi1 in tumorigenesis and generation of cancer stem cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The recent identification of cancer stem cells in solid tumors changes the traditional paradigm for how some cancers arise and ultimately how they are treated. In order to understand the biology of cancer stem cells and therefore develop targeted treatment strategies to eradicate them, a model is required where the cancer initiating cell is known, tumor formation progresses in a timely manner and the resulting cancer stem cell population can be reproducibly isolated from the resulting tumor. To meet this need we have developed a quantitative model in which teratocarcinomas are generated within 6 weeks from cancer initiating cells called embryonic germ cells. The resulting carcinomas are composed of well-differentiated tumor cells, and a stem cell population comprising 4-8% of the bulk tumor. These cancer stem cells can be isolated and re-grown in vitro or re-transplanted in vivo. Using this model we can now evaluate genetic pathways that are hypothesized to impact cancer pathogenesis from the tumor initiating cells, as well as formation and activity of cancer stem cells in this tumor. Using gene expression profiling we compared human embryonic stem cells to teratocarcinoma stem cells and determined that Bmi1 is significantly up-regulated in the cancer stem cells compared to normal embryonic stem cells. Therefore, the hypothesis to be addressed in is that elevated expression of Bmi1 in tumor-initiating cells will result in increased and faster tumor growth and an increase in the percentage of cancer stem cells compared to controls. In order to address this hypothesis, Bmi1 expression will be elevated in the cancer initiating cells using lentiviral transduction, where Bmi1 expression will be driven by the Ubiquitin promoter. Tumor growth from Bmi1 over expressing cells will be quantified using live animal imaging. Next the downstream targets of Bmi1 including p16 and p19 and phosphorylated Retinoblastoma protein will be evaluated in both the cancer initiating cells and cancer stem cells to determine mode of activity during tumorigenesis and formation of cancer stem cells. Finally, we will evaluate the self-renewal and differentiation capacity of cancer stem cells with elevated levels of Bmi1 by re-transplanting the cancer stem cells into a second recipient mouse and quantifying tumor growth using live animal imaging followed by assessment of tumor histology. At the conclusion of these experiments, the role of Bmi1 in tumor pathogenesis and cancer stem cell biology using a teratocarc
Tetramorium tosii
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium tosii

description: The tosii -group
Antennae with 12 segments, sting appendage dentiform. Mandibles sculptured. Anterior clypeal margin entire, without trace of a median notch or impression. Body with erect or suberect fine hairs present but dorsal (outer) surfaces of hind tibiae without such hairs. Petiole node in profile elongate and low (Figs 31, 33). Frontal carinae running back well beyond the level of the eyes. Large species, HW> 0.90. Antennal scrobes absent.
The two species in this small group represent the only endemic members of Tetramorium in the entire Malagasy region in which the antennae are 12 - merous and which are not obviously derived from any based on the Ethiopian region.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 152
Replication and pathogenesis of XMRV; a new human retrovirus associated with prostate cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Xenotropic murine leukemia virus-related virus (XMRV) is a newly discovered human gamma-retrovirus identified in prostate cancer tissue from patients homozygous for a reduced activity variant of the antiviral enzyme RNase L. The casual relationship of XMRV infection to prostate cancer and the mechanism of tumorigenesis have not yet been established. In addition, the mode of viral transmission in humans and whether XMRV can cause pathological changes in human tissues other than the prostate are not known. The objectives of this proposal are to confirm the presence of XMRV in human blood samples, and to test the ability of XMRV to infect and replicate in various human blood cells in vitro and human chimeric mouse models in vivo. We have obtained a molecular viral clone of XMRV that is replication-competent in human cells. The ability of XMRV to infect various human cells and tissues will be analyzed by a real-time, quantitative PCR, reverse transcriptase activity, and ELISA with a monoclonal antibody that can corss-react with the XMRV Gag protein. SCID-hu Thy/Liv and NOD-SCID mice will be used to test the ability of XMRV to infect human tissues and replicate within a mouse host. The information obtained will shed light on the possible route of viral transmission, and provide a better understanding of viral tropism. Successful infection of XMRV in the chimeric mice will also provide an animal model amendable for studying the replication and pathogenesis of XMRV. The study will also impact significantly our appreciation of the role of viral infection in human cancers, and has practical applications in identifying viral or new cellular targets for treatment.
The Development of On-glides in American English
Creators: name: Barlow, Jessica A.
Publisher: name: Cascadilla Press
Year: 1996

description: The status of the C/y/ sequence as a consonant cluster has motivated an investigation into the representation of such sequences in comparison to C/w/ and consonant-liquid sequences in data from developing systems. Evidence from production and substitution patterns indicated that children showed different patternings for the consonant-glide sequences,  such that for some children the palatal glide patterned as part of the onset of a syllable, whereas for other children it patterned as part of the nucleus. Results support the claim that the palatal glide of the C/y/ sequence patterns as part of both the onset and the nucleus of a syllable. The seemingly ambivalent behavior of glides would then follow from a complex structure and different constraint rankings
Additional file 1: Figure S1. of Analyses of methylomes of upland and lowland switchgrass (Panicum virgatum) ecotypes using MeDIP-seq and BS-seq
Creators: name: Mollee Dworkin
name: Shaojun Xie
name: Saha, Malay
name: Jyothi Thimmapuram
name: Venu Kalavacharla
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology

description: Meta-plots of DNA methylation level across gene without intronic TE. (PDF 7Â kb)
Feature classes
Creators: name: Padgett, Jaye
Publisher: name: GLSA (Graduate Linguistic Student Association), Dept. of Linguistics, University of Massachusetts
Year: 1995

description: This paper and the next investigate the status of feature classes like Place and Laryngeal in featural phonology. In a departure from Feature Geometry, I argue that constraints mentioning such classes are gradiently violable in the sense given within Optimality Theory. The result is what I call partial class behavior: under compulsion of a constraint mentioning an entire feature class, only a proper subset of the relevant features spread, for reasons of markedness, locality or whatever. This idea leads to feature class generalizations that are not visible to Feature Geometry.ROA-112 strengthens the evidence for a class Color (cf. Odden's 1991 [back]/[round]), arguing that the copatternings of [back] and [round] harmonies in Turkic and other languages represent instances of Color harmony, formerly unrecognized only because Color spreading is often gradiently violated, leading to partial class behavior. This paper also argues for an understanding of segment transparency as segment participation, following work of Smolensky and McCarthy.ROA-113 focuses on nasal place assimilation and has two goals. The first is to demonstrate the robust existence of partial class behavior in nasal place assimilation, and so further motivate the ideas outlined above. The second is to better understand nasal place assimilation itself. This latter goal leads to proposals for the employment of a release feature in phonology (following Steriade) and for very general spreading constraints.'Partial Class Behavior and Nasal Place Assimilation' by Jaye Padgett supersedes this article, 'Feature Classes'  in some technical details, and the two papers should be read together.
Tetramorium tantillum Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium tantillum

description: Tetramorium tantillum sp. n.
(Figs 30, 31)
Holotype worker. TL 4.5, HL 1.09, HW 0.92, CI 90, SL 0.74, SI 80, PW 0.70, AL 1.22.
Mandibles with faint and delicate longitudinal striation, the anterior clypeal margin arcuate and entire. Clypeus medially with only three longitudinal carinae. Eyes moderate, maximum diameter 0.21, about 0.23 x HW, not strongly protuberant. Frontal carinae long, almost reaching occipital region before merging with other cephalic sculpture, but not strong, no more strongly developed than the longitudinal rugae between them. The frontal carinae very weakly sinuate along their length, broadest at about level of eyes and converging slightly posteriorly, not diverging towards the occipital corners. Outline shape of lateral alitrunk as in Fig. 31. Propodeal spines straight and acute, metapleural lobes broad and bluntly triangular. Pedicel in profile as in Fig. 31, in dorsal view the petiole node roughly globular, very slightly broader than long and distinctly more voluminous than the postpetiole. Dorsum of head with irregular longitudinal rugae which are widely spaced, about 7 between the frontal carinae at the level of the eyes. Spaces between rugae with feeble ground-sculpture which amounts to little more than a slight roughening of the surface. Dorsal alitrunk with low, rounded, very weak rugae which form a feeble, almost effaced reticulum on the promesonotum. Dorsal surfaces of petiole and postpetiole smooth, with superficial faint markings which resemble an almost effaced fine reticulate-punctulation. Sides of petiole node with a few vestigial rugulae. Gaster unsculptured. All dorsal surfaces of head and body with numerous hairs, mostly erect or sub-erect. Colour uniform dark brown.
Paratype workers. TL 4.2 - 4.4, HL 1.00 - 1.02, HW 0.88 - 0.90, CI 88 - 90, SL 0.70 - 0.74, SI 79 - 82, PW 0.64 - 0.68, AL 1.12 - 1.88. Maximum diameter of eye 0.19 - 0.21 (3 measured).
Holotype worker, Madagascar: Mangabe Isl., Antongil Bay 19. ii. 1977, prim. rain forest, AB 42 litter (W. L. & D. E. Brown) (MCZ, Cambridge). Paratypes. 3 workers with same data as holotype (MCZ, Cambridge; BMNH).
Closely related to tosii but not as specialized as that species. The eyes in tantillum are much less prominent, the scapes and propodeal spines shorter, and the petiole node is constructed differently (Figs 30, 31 and 32, 33).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 152-153
Targeting EMP2 in endometrial cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Endometrial cancer (EC) is the most common malignancy of the female genital tract. Few modalities exist for its treatment, and like most cancers new treatments are needed. Epithelial Membrane Protein-2 is an adaptor protein in integrin-FAK signaling, which plays a critical physiologic role in the endometrium for blastocyst implantation. Using local UCLA funding, we identified it as the first biomarker informative for endometrial cancer survival. In a collaborative tissue microarray study, EMP2 expression was correlated with poor prognosis, and was also increased in a subset of patients with EC premalignancy. Preliminary data suggest that recombinant EMP2 antibodies, recently produced in our lab, inhibit proliferation and induce apoptosis in vitro. Accordingly, our hypothesis is that EMP2 expression may be required for the malignant phenotype in a subset of EC, and could represent a therapeutic target in patients with EMP2-positive EC. In this proposal, we seek to test the rationale and feasibility of EMP2-directed antibody cancer immunotherapy. Our specific aims are to evaluate the effectiveness of these recombinant EMP2 antibodies by in vivo molecular imaging with positron emission tomography, and as therapeutic agent for human endometrial carcinoma cell line xenografts in vivo. If successful, these aims will provide preclinical evidence for the therapeutic use of EMP2 antibodies, or biologic targeting of EMP2 expression, as a new strategy for biotherapy of EC. This progress would strengthen our efforts to secure large-scale funding to advance this therapeutic endeavor, to elucidate the underlying cell biology linking EMP2 to the malignant phenotype, the tumoricidal action of anti-EMP2, and approaches that could link anti-EMP2 therapy to associated downstream signaling targets (notably the FAK-SRC pathway). Anti-EMP2 is also likely to be pertinent to other categories of malignancy, since EMP2 expression is upregulated in subsets in a variety of malignancies, including acute lymphocytic leukemias, gliomas, head/neck, lung, breast, and ovarian cancer. This qualifies in the REG category, since it represents a new entry into the cancer field: my work has previously concerned inflammatory bowel disease, and endometrial physiology (blastocyst implanatation).
The Inadequacy of Filters and Faithfulness in Loanword Adaptation
Creators: name: Paradis, Carole
Publisher: name: European Studies Research Institute, University of Salford
Year: 1996

description: The objective of this paper is twofold. First, it aims to show that segment deletion in borrowings is largely predictable, and that this predictability might be problematic for a filter-based framework since, as we will see, it entails that phonological processes are visible to phonological constraints.  For instance, it is at odds with a filter-based framework such as Optimality Theory (OT; Prince & Smolensky 1993 and McCarthy & Prince 1993), where constraints are in fact "filters", i.e. surface constraints, which do not have access to the processes of the phonological component or the intermediate forms they generate since, by definition, filters deal with final outputs only. Second, this paper will demonstrate that ill-formed segments contained in borrowings are adapted, i.e. recast into a different shape (85.2% of cases), or left unadapted (10.&% of cases) - if these are imports - instead of being deleted. Phonologically-induced segment deletion represents only 2.3% of cases, a fact which is attributed to a principle of the Theory of Constraints and Repair Strategies (TCRS; Paradis 1988a,b), the Preservation Principle. It will be shown that, although the Preservation Principle and Faithfulness (Parse and Fill) in OT seem comparable, they make indeed different predictions. In the view of Faithfulness, the optimal output (candidate) is the one which has undergone the least (segment) deletion, i.e. the one whose segments are all "parsed" (realised), in addition to being the one which has undergone the least (segment) epenthesis (Fill). In other words, the Faithfulness constraints (Parse and Fill) establish that the best candidate is the one which is as close as possible to its input. OT treats both Faithfulness constraints on a par in the sense that their ranking with respect to one another - as is the case with any other constraint in this framework - is determined on language-specific grounds, not universal ones. This means that, statistically, segment deletion in loanwords across languages should be observed as often as segment insertion, a prediction which is not empirically supported.
Additional file 1: of Predicting high risk births with contraceptive prevalence and contraceptive method-mix in an ecologic analysis
Creators: name: Perin, Jamie
name: Agbessi Amouzou
name: Neff Walker
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Supplementary material is provided for the hierarchical modelling results. (DOCX 18Â kb)
Ariopsis seemanni
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Ariopsis
Ariopsis seemanni

description: Ariopsis seemanni (Günther 1864). Tete Sea Catfish; Cominata Negra, Bagre Tete
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from the Gulf of California, Mexico, to northern Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER, PN and Ni (Pacific); 0–32 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown.
Literature: Villa (1982: 115; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 139; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Robertson & Allen (2015: 574; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 31; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 28, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Prosodic Faithfulness in Cupeño
Creators: name: Alderete, John
Publisher: name: GLSA Publications
Year: 1996

description: This paper develops an Optimality Theoretic analysis of Cupeno accent. This analysis crucially depends on underlying specifications of prosody and constraints on faithfulness to underlying prosody. Input-Output prosodic faithfulness is necessary in accounting for distinctive stress in the inventory of accentual patterns observed in roots. Prosodic faithfulness is equally important in explaining the observation that root stress overrides affix stress; in fact, this observation is accounted for as a special case of the crosslinguistic tendency for roots to license a wider range of contrasts than affixes, an explanation that is not available to plausible alternatives. Finally, faithfulness to underlying prosody is shown to be crucial in describing a pattern of unbounded stress, essentially characterizing the intrinsic prominence of underlying accent.
Additional file 3: of Using the missed opportunity tool as an application of the Lives Saved Tool (LiST) for intervention prioritization
Creators: name: Tam, Yvonne
name: Luwei Pearson
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: List of interventions and their definitions. This file contains the definitions of interventions that correspond to the top 5 missed opportunities in DRC, Ethiopia, Kenya, and Tanzania. Also included are definitions of delivery levels for labor and delivery management. (DOCX 17Â kb)
Lexicon Optimization in Languages without Alternations
Creators: name: Yip, Moira
Publisher: name: European Studies Research Institute, University of Salford
Year: 1996

description: Languages with few or no alternations have never fitted smoothly into rule-based theories with a commitment to lexical economy. To derive rich surface inventories from more parsimonious underlying inventories, it was necessary to postulate abstract underlying forms even for morphemes which only ever surfaced with one particular allophone. Even if lexical economy was demoted as a paramount consideration, the occurrence of alternations in one small corner of the grammar, such as in loanwords, still forced the linguist back to the abstract and rule-based analysis. This was so because the alternative, a set of phonotactic statements about the surface distribution of allophones, could not alone produce alternations: only rules could do that, and once the grammar included rules, they could be made use of for other purposes, including the non-alternating forms. Output-based theories are tailor-made for language of this type. Surface-true generalizations can be trivially dealt with. When alternations are encountered, they can be understood as the direct result of the pressure to observe these surface constraints, and no special rules are needed.Using data from vowel systems in several Chinese dialects, Mandarin palatal consonants, and Chaoyang nasalization, it is argued that abstract underlying representations and rules that produce surface forms are highly inefficient for non-alternating systems, in that they frequently require both rules that derive A from B, and rules that derive B from A, in the same contexts. It is proposed that language is learnt on the basis of core data, and that non-core data - language games, poetry, speech errors, onomatopoeia, loanwords - can be used as a probe to investigate the nature of the underlying representations. This paper finds inconclusive evidence for abstract underlying representations, and concludes that the balance of the evidence suggests that learners acquire something rather close to what they hear, unless information from alternations or paradigms forces them to do otherwise. These findings provide support for Lexicon Optimization (Prince and Smolensky 1993).
Correspondence and Compositionality: The Ga-gyō Variation in Japanese Phonology
Creators: name: Itô, Junko
name: Mester, Armin
Publisher: name: Oxford University Press
Year: 1996

description: This paper explores the theoretical consequences of surface-to-surface correspondence constraints in Optimality Theory, in comparison to a derivational approach employing sequential derivational mechanisms like cyclicity and ordered default rules. The empirical object of investigation are the facts of the g-N(angma) alternation and variation in Tokyo Japanese. The central argument of the paper is that the OT analysis is better equipped to handle the facts of the alternation, which are truly intricate and interesting, since an (at first glance) simple process of allophony is complicated by subpatterns of optionality vs. obligatoriness, governed by factors such as the presence vs. absence of related words and the influence of Rendaku voicing.
Identification of dopamine regulated molecular effectors involved in the genesis of pituitary tumors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Prolactinomas are the most common pituitary tumors, occurring frequently in females of 20-50 years of age. Aberrant growth of lactotrops and very high levels of prolactin in serum characterize these tumors whose genesis is still largely unknown. Dopamine (DA) acting through DA D2 receptors (D2R) is a major regulator of lactotrop physiology and modulates inputs from different hormones and growth factors on these cells. In agreement with this, we have shown that mice lacking D2Rs - D2R-/- mice - develop prolactinomas. Indeed, the current and most efficient therapy for treatment of prolactinomas is the use of DAergic agonists, such as bromocriptine and cabergoline. Nonetheless, a great variability has been reported in the response of these tumors to DAergic agonists, which has been correlated to the decrease of D2 binding sites and/or altered composition of D2Rs. D2R sites are formed by two molecularly distinct isoforms, D2L and D2S generated by alternative splicing of the same gene. We have shown that overexpression of D2S in transgenic mice leads to an increased stimulation of the MAPK pathway, and to a strong inhibition of prolactin synthesis and lactotrop growth. Conversely, D2L overexpression does not impact on the MAPK pathway and results in increased circulating levels of prolactin and subsequent lactotrop hyperplasia. Our preliminary results indicate that in D2R-/- pituitary the AKT/PKB pathway is stimulated as found in human tumors. Thus, indicating that DA negatively controls activation of this pathway by growth factors such as TGF, in normal conditions. Activation of the AKT/PKB pathway has been reported to inhibit the MAPK pathway. We propose to unravel the critical pathway/s responsible for the occurrence of prolactinomas. To do so, we will perform pharmacological stimulation of mice lacking either D2L or D2S with hormones (i.e. estrogen) and analyze the occurrence of prolactinomas. In parallel we will test the pharmacological effect of bromocriptine and cabergoline in preventing lactotrops proliferation. The analysis of D2R isoform’s specific pathways, of their effect on lactotrop growth and prolactin levels will provide novel insights of critical pharmacological importance. This study will lead to alternative therapies for treating resistant prolactinomas by revealing molecular targets downstream of D2Rs.
Atlantodesmus pintoi
Creators: name: Bouzan, Rodrigo Salvador
name: Iniesta, Luiz Felipe Moretti
name: Brescovit, Antonio Domingos
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Polydesmida
Chelodesmidae
Atlantodesmus
Atlantodesmus pintoi

description: Atlantodesmus pintoi (Schubart, 1946)
BRAZIL • 1 ♂, 1 ♀; Bahia, Una, Reserva Biológica de Una; 39°02′98″ W, 15°19′54″ S; Nov. 2001; A.D. Brescovit coll.; IBSP 1001.
description: Published as part of Bouzan, Rodrigo Salvador, Iniesta, Luiz Felipe Moretti & Brescovit, Antonio Domingos, 2019, Cladistic analysis and description of a new species of the Brazilian genus Atlantodesmus Hoffman, 2000 (Diplopoda: Polydesmida: Chelodesmidae), pp. 1-17 in European Journal of Taxonomy 538 on page 16, DOI: 10.5852/ejt.2019.538, http://zenodo.org/record/3346493
Regulation of the yeast S phase checkpoint through a conserved Zn++ finger domain in the replication protein Dbf4
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The S phase checkpoint is a conserved signal transduction pathway whose critical function is to maintain replication fork stability during DNA replication distress. Compromised S phase checkpoint signaling leads to replication fork collapse and uncontrolled cell cycle progression, resulting in genome instability that can promote cancer cell development. The yeast Rad53 protein kinase (Chk2 in human cells) is a central transducer of the S phase checkpoint. One downstream target of Rad53 is the Dbf4 protein. In response to DNA replication distress, Dbf4 is phosphorylated in a Rad53-dependent manner, and this regulation is thought to block the ability of the Dbf4/Cdc7 kinase complex to activate origins of DNA replication. Thus, when replication fork progression is perturbed, the S phase checkpoint actively prevents additional replication origins from firing, which probably helps limit the numbers of forks experiencing the replication problem. In this application we describe evidence that, in addition to modulating origin firing, Rad53 regulation of Dbf4 may also play a novel role in S phase checkpoint cell cycle arrest. Specifically, mutations affecting a highly conserved but little studied Zn++ finger domain in the C-terminus of Dbf4 relieve the S phase checkpoint cell cycle arrest defect of rad53 mutants. This suggests Rad53 inhibition of activities associated with the Dbf4 C-terminus is involved in controlling cell cycle arrest. This is completely unexpected based on current models of S phase checkpoint organization. The goals of this project are therefore to: 1) Examine phenotypes associated with mutations in the Dbf4 C-terminal Zn++ finger region; 2) Examine aspects of Rad53 signaling that are restored in dbf4 C-terminal mutants; 3) Test a specific model for how inhibition of Dbf4 controls cell cycle arrest. This project is unrelated to currently funded work in my lab. I anticipate CRCC funding will allow us to develop this project to a point where we can hopefully secure extramural funding for an additional research focus within my laboratory on the S phase checkpoint.
Olivierus przewalskii
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Buthidae
Olivierus
Olivierus przewalskii

description: (3) Olivierus przewalskii (Birula, 1897)
TYPE LOCALITY AND TYPE DEPOSITORY. China, Xinjiang Uygur Autonomous Region, Bayingolin Mongol Autonomous Prefecture, near Lop Nur Lake and Cherchen Oasis, in the east edge of Tarim Basin; ZISP.
PROTONYM. Buthus caucasicus przewalskii Birula, 1897.
NOMEN NUDUM. Mesobuthus nanjiangensis Zhang, 2009.
CHINESE EQUIVALENT. Î氏Dz氏x.
DISTRIBUTION (○). Gansu: Dunhuang and Jiuquan (Guazhou County) cities; Inner Mongolia: Alxa League (Ejina Banner); Xinjiang: Aksu (Aksu and Kuqa cities), Bayingolin (Bügür, Qiemo, Ruoqiang, and Yuli counties; Korla City), Bortala (Bole City), Ili (Ghulja County), Kashgar (Yarkant and Makit counties), and Kizilsu (Artux City; Wuqia County) prefectures, Turpan (Shanshan and Toksun counties), Tiemenguan, and Tumxuk cities, and Yizhou District (Hami City).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 15, DOI: 10.5281/zenodo.14660932
Sprouty2 loss in melanoma pathogenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Deregulation of the RAS/MAPK pathway is a common defect in human cancer. The RAS/MAPK pathway is inhibited by a conserved family of intracellular proteins called Sproutys. We have identified a deletion of the SPRY2 locus in human melanoma that is present in the majority of melanomas that arise from sun damaged skin. In fibroblast transformation assays, Spry2 functions as a tumor suppressor. Preliminary results also indicate that Spry2 loss affects the growth of melanocytes in culture. These findings have led us to ask how Spry2 controls melanocyte growth and which deregulated components of the RAS/MAPK pathway contribute to altered growth controls. We propose to identify the components of RTK signal transduction pathway that are affected by Spry2 loss in Spry2-deficient fibroblasts and melanocytes following growth factor stimulation. The hypothesis that loss of Spry2 confers improved survival and growth of melanocytes will be tested in Spry2-deficient melanocytes. Lastly, a role for Spry2 in c-Kit signal transduction will be examined in cultured melanocytes and in genetic interaction studies.
Mongolian Stress, Licensing, and Factorial Typology
Creators: name: Rachel, Walker
Publisher: name: University of California, Santa Cruz
Year: 1997

description: This paper examines the analysis and typology of prominence-based stress systems, which do not call on binary rhythms but depend solely on factors such as syllable weight or sonority, peripherality, and nonfinality in locating stress (Prince 1983, 1990; Prince & Smolensky 1993). Four prominence-driven constraints are defined which position stress independent of foot structure. Pursuing the optimality-theoretic hypothesis that typology derives from factorial constraint ranking, it is established that reranking accurately captures attested variation, and further, that the range of prominence-driven patterns is richer than previous conceptions, including variation in nonfinality effects. Two important empirical and theoretical findings are presented. First, new data from East Mongolian dialects are introduced, correcting a misinterpretation of the Khalkha stress pattern and illuminating the analysis with a case uniquely employing all four prominence-driven constraints. Second, opposite-edge default is argued to be a categorical licensing effect, informed by the typological result that nonfinality only fails to cooccur with opposite-side systems when the default is to the right. This finds new evidence for Zoll's (1996) licensing account of conflicting directionality and offers an argument against alternative foot-based analyses.