cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effect of Syzygium cumini and Bauhinia forficata aqueous-leaf extracts on oxidative and mitochondrial parameters in vitro
Creators: name: Ecker, Assis
name: Araujo Vieira, Francielli
name: De Souza Prestes, Alessandro
name: Mulling Dos Santos, Matheus
name: Ramos, Angelica
name: Dias Ferreira, Rafael
name: Teixeira De Macedo, Gabriel
name: Vargas Klimaczewski, Claudia
name: Lopes Seeger, Rodrigo
name: Teixeira Da Rocha, João Batista
name: De Vargas Barbosa, Nilda B.
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: Bauhinia forficate
subject: Syzygium cumini
subject: mitochondria
subject: antioxidant properties
subject: 610

description: Aqueous-leaf extract of Syzygium cumini and Bauhinia forficata are traditionally used in the treatment of diabetes and cancer, especially in South America, Africa, and Asia. In this study, we analyzed the effects of these extracts on oxidative and mitochondrial parameters in vitro, as well as their protective activities against toxic agents. Phytochemical screenings of the extracts were carried out by HPLC analysis. The in vitro antioxidant capacities were compared by DPPH radical scavenging and Fe2+ chelating activities. Mitochondrial parameters observed were swelling, lipid peroxidation and dehydrogenase activity. The major chemical constituent of S. cumini was rutin. In B. forficata were predominant quercetin and gallic acid. S. cumini reduced DPPH radical more than B. forficata, and showed iron chelating activity at all tested concentrations, while B. forficata had not similar property. In mitochondria, high concentrations of B. forficata alone induced a decrease in mitochondrial dehydrogenase activity, but low concentrations of this extract prevented the effect induced by Fe2++H2O2. This was also observed with high concentrations of S. cumini. Both extracts partially prevented the lipid peroxidation induced by Fe2+/citrate. S. cumini was effective against mitochondrial swelling induced by Ca2+, while B. forficata alone induced swelling more than Ca2+. This study suggests that leaf extract of S. cumini might represent a useful therapeutic for the treatment of diseases related with mitochondrial dysfunctions. On the other hand, the consumption of B. forficata should be avoided because mitochondrial damages were observed, and this possibly may pose risk to human health.
description: EXCLI Journal;Vol. 14, 2015
Unraveling two-photon entanglement via the squeezing spectrum of light traveling through nanofiber-coupled atoms
Creators: name: Hinney, Jakob
name: Prasad, Adarsh S.
name: Mahmoodian, Sahand
name: Hammerer, Klemens
name: Rauschenbeutel, Arno
name: Schneeweiss, Philipp
name: Volz, Jürgen
name: Schemmer, Max
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We observe that a weak guided light field transmitted through an ensemble of atoms coupled to an optical nanofiber exhibits quadrature squeezing. From the measured squeezing spectrum we gain direct access to the phase and amplitude of the energy-time entangled part of the two-photon wavefunction which arises from the strongly correlated transport of photons through the ensemble. For small atomic ensembles we observe a spectrum close to the lineshape of the atomic transition, while sidebands are observed for sufficiently large ensembles, in agreement with our theoretical predictions. Furthermore, we vary the detuning of the probe light with respect to the atomic resonance and infer the phase of the entangled two-photon wavefunction. From the amplitude and the phase of the spectrum, we reconstruct the real- and imaginary part of the time-domain wavefunction. Our characterization of the entangled two-photon component constitutes a diagnostic tool for quantum optics devices.
Evaluation of the Episiotomy Scissors Attached with an Adjusted Angle Plate for Mediolateral Episiotomy on the Occurrence of Obstetric Anal Sphincter Injuries
Creators: name: Phiangjit Wiruchpongsanon
Publisher: name: PIMDEE Co., Ltd.
Year: 2024
Subjects: episiotomy scissors
adjusted angle plate
mediolateral episiotomy
obstetric anal sphincter injuries

description: Thai Journal of Obstetrics and Gynaecology, 32, 1, 68-75
Equivalence and practice effect of alternate forms for Malay version of Auditory Verbal Learning Test (MAVLT)
Creators: name: Munjir, Norulsuhada
name: Othman, Zahiruddin
name: Zakaria, Rahimah
name: Shafin, Nazlahshaniza
name: Hussain, Noor Aini
name: Desa, Anisah Mat
name: Ahmad, Asma Hayati
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: MAVLT
subject: alternate forms
subject: practice effect
subject: equivalency
subject: neuropsychological testing
subject: 610

description: This study aims to develop two alternate forms for Malay version of Auditory Verbal Learning Test (MAVLT) and to determine their equivalency and practice effect. Ninety healthy volunteers were subjected to the following neuropsychological tests at baseline, and at one month interval according to their assigned group; group 1 (MAVLT - MAVLT), group 2 (MAVLT – Alternate Form 1 - Alternate Form 1), and group 3 (MAVLT - Alternate Form 2 - Alternate Form 2). There were no significant difference in the mean score of all the trials at baseline among the three groups, and most of the mean score of trials between MAVLT and Alternate Form 1, and between MAVLT and Alternate Form 2. There was significant improvement in the mean score of each trial when the same form was used repeatedly at the interval of one month. However, there was no significant improvement in the mean score of each trial when the Alternate Form 2 was used during repeated neuropsychological testing. The MAVLT is a reliable instrument for repeated neuropsychological testing as long as alternate forms are used. The Alternate Form 2 showed better equivalency to MAVLT and less practice effects.
description: EXCLI Journal;Vol. 14, 2015
Η οικονομική ανάλυση του Blockchain
Creators: name: Ανδρονής, Σόλων
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Blockchain
subject: Blocks
subject: Κρυπτονομίσματα
subject: Πρωτόκολλο λειτουργίας
subject: Αλγόριθμος συναίνεσης
subject: Ιδιωτικά και δημόσια blockchain
subject: Smart contracts
subject: Double spending
subject: Επίθεση 51%
subject: Ψηφοφορία
subject: Blockchain trilemma
subject: Proof of Work (PoW)
subject: Proof of Stake (PoS)
subject: Private blockchain
subject: Χειραγώγηση συναίνεσης

description: Η τεχνολογία του Blockchain χαρακτηρίζεται από την αποκεντροποιημένη μορφή συναίνεσης μεταξύ αντισυμβαλλόμενων ατόμων, με χαμηλές σε κόστος πραγματοποίησης και ελέγχου συναλλαγές αντίθετο με τα παραδοσιακά κεντροποιημένα συστήματα. Το blockchain δεν συνδέεται μόνο με τα κρυπτονομίσματα αλλά ήδη έχει πολλά πεδία εφαρμογής και υπάρχουν πολλά σημάδια πως θα διαταράξει (disrupt) τον επιχειρηματικό και χρηματοοικονομικό κόσμο αναδύοντας νέες αγορές, τομείς αλλά και εφαρμογές όπως είναι τα Smart Contracts. Καταγράφουμε λοιπόν και αναλύουμε την τεχνολογία του blockchain πως συνδέεται με τις χαμηλές σε κόστος συναλλαγές, πως είναι η δομή της αρχιτεκτονική ενός blockchain συστήματος, αναλύσουμε τα πεδία εφαρμογής του και εξετάζοντας το βασικό αποτέλεσμα του άρθρου των Abadi J. και Brunnermeier M. (2019) που είναι το blockchain trilemma εφαρμόζουμε το μαθηματικό τους μοντέλο για να ερευνήσουμε πως μπορεί να επιτευχθεί η χειραγώγησης του blockchain δικτύου σε συγκεκριμένες περιπτώσεις αλγορίθμων συναίνεσης.
On the Wess-Zumino term in high energy QCD
Creators: name: Hatta, Yoshitaka
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recently, Kovner and Lublinsky proposed new small-x QCD evolution equations valid when the gluon density inside the target is low. The key element of their construction is the Wess-Zumino term which ensures the non-commutativity of valence charges. In this paper we clarify the origin and significance of this term by showing that it can be naturally incorporated in the effective theory of Color Glass Condensate. We also reexamine the renormalization group description in the high density (JIMWLK) regime.
description: 21 pages
mRNA Expression Profiling in Hydatidiform Mole: Comparison between Pre-Gestational Trophoblastic Neoplasia Moles and Remission Moles
Creators: name: Wilasinee Areeruk
Publisher: name: PIMDEE Co., Ltd.
Year: 2024
Subjects: gestational trophoblastic neoplasia
postmolar GTN
mRNA
nanostring

description: Thai Journal of Obstetrics and Gynaecology, 32, 1, 76-84
The improvement of large High-Density Lipoprotein (HDL) particle levels, and presumably HDL metabolism, depend on effects of low-carbohydrate diet and weight loss
Creators: name: Finelli, C.
name: Crispino, P.
name: Goiia, S.
name: La Sala, N.
name: D'amico, L.
name: La Grotta, M.
name: Miro, O.
name: Colarusso, D.
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: obesity
subject: HDL
subject: low carbohydrate diet and weight loss
subject: 610

description: Depressed levels of atheroprotective large HDL particles are common in obesity and cardiovascular disease (CVD). Increases in large HDL particles are favourably associated with reduced CVD event risk and coronary plaque burden. The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year. This study was performed by screening for body mass index (BMI) and metabolic syndrome in 160 consecutive subjects referred to our out-patient Metabolic Unit in South Italy. We administered dietary advice to four small groups rather than individually. A single team comprised of a dietitian and physician administered diet-specific advice to each group. Large HDL particles at baseline and 1 year were measured using two-dimensional gel electrophoresis. Dietary intake was assessed via 3-day diet records. Although 1-year weight loss did not differ between diet groups (mean 4.4 %), increases in large HDL particles paralleled the degree of carbohydrate restriction across the four diets (p<0.001 for trend). Regression analysis indicated that magnitude of carbohydrate restriction (percentage of calories as carbohydrate at 1 year) and weight loss were each independent predictors of 1-year increases in large HDL concentration. Changes in HDL cholesterol concentration were modestly correlated with changes in large HDL particle concentration (r=0.47, p=.001). In conclusion, reduction of excess dietary carbohydrate and body weight improved large HDL levels. Comparison trials with cardiovascular outcomes are needed to more fully evaluate these findings.
description: EXCLI Journal;Vol. 15, 2016
Ovarian Tumour Presenting as an Inguinal Hernia in a Postmenopausal Woman with Mullerian Agenesis: A case report
Creators: name: Rangasamy, Aruna
Publisher: name: PIMDEE Co., Ltd.
Year: 2024
Subjects: inguinal hernia
ovarian tumour
mullerian agenesis
MRKH (Mayer-Rokitansky-Kuster-Hauser) syndrome

description: Thai Journal of Obstetrics and Gynaecology, 32, 1, 85-90
Quantum noise minimization in transistor amplifiers
Creators: name: Gavish, U.
name: Yurke, B.
name: Imry, Y.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: General quantum restrictions on the noise performance of linear transistor amplifiers are used to identify the region in parameter space where the quantum-limited performance is achievable and to construct a practical procedure for approaching it experimentally using only the knowledge of directly measurable quantities: the gain, (differential) conductance and the output noise. A specific example of resonant barrier transistors is discussed.
description: 4 pages
Variational method for lattice spectroscopy with ghosts
Creators: name: Burch, Tommy
name: Gattringer, Christof
name: Glozman, Leonid Ya.
name: Hagen, Christian
name: Lang, C. B.
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We discuss the variational method used in lattice spectroscopy calculations. In particular we address the role of ghost contributions which appear in quenched or partially quenched simulations and have a non-standard euclidean time dependence. We show that the ghosts can be separated from the physical states. Our result is illustrated with numerical data for the scalar meson.
description: 4 pages, 1 figure
Linear response in the uniformly heated granular gas
Creators: name: Sánchez-Rey, B.
name: Prados, A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We analyse the linear response properties of the uniformly heated granular gas. The intensity of the stochastic driving fixes the value of the granular temperature in the non-equilibrium steady state reached by the system. Here, we investigate two specific situations. First, we look into the ``direct'' relaxation of the system after a single (small) jump of the driving intensity. This study is carried out by two different methods. Not only do we linearise the evolution equations around the steady state, but also derive generalised out-of-equilibrium fluctuation-dissipation relations for the relevant response functions. Second, we investigate the behaviour of the system in a more complex experiment, specifically a Kovacs-like protocol with two jumps in the driving. The emergence of anomalous Kovacs response is explained in terms of the properties of the direct relaxation function: it is the second mode changing sign at the critical value of the inelasticity that demarcates anomalous from normal behaviour. The analytical results are compared with numerical simulations of the kinetic equation, and a good agreement is found.
description: 14 pages, 10 figures; major revision; completely new section on non-equilibrium FDR; accepted for publication in PRE
Electron Spin-Lattice Relaxation of Er3+ ions in Er0.01Y0.99Ba2Cu3Ox
Creators: name: Ivanshin, V. A.
name: Gafurov, M. R.
name: Kurkin, I. N.
name: Kurzin, S. P.
name: Shengelaya, A.
name: Keller, H.
name: Gutmann, M.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The temperature dependence of the electron spin-lattice relaxation SLR was studied in Er0.01Y0.99Ba2Cu3Ox compounds. The data derived from the electron spin resonance ESR and SLR measurements were compared to those from inelastic neutron scattering studies. SLR of Er3+ ions in the temperature range from 20 K to 65 K can be explained by the resonant phonon relaxation process with the involvement of the lowest excited crystalline-electric-field electronic states of Er3+. These results are consistent with a local phase separation effects. Possible mechanisms of the ESR line broadening at lower temperatures are discussed. Keywords: YBCO; EPR; ESR; Electron spin-lattice relaxation time, T ; Crystalline-electric-field
description: 6 pages, 4 figures
DNA methylation assessment as a prognostic factor in invasive breast cancer using methylation-specific multiplex ligation dependent probe amplification
Creators: name: Shakeri, Halaleh
name: Gharesouran, Jalal
name: Fakhrjou, Ashraf
name: Esfahani, Ali
name: Mohaddes Ardebili, Seyyed Mojtaba
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: MS-MLPA
subject: methylation
subject: breast cancer
subject: IDC
subject: tumor suppressor genes
subject: 610

description: DNA methylation of promoter regions is a common molecular mechanism for inactivation of tumor suppressor genes that participates in carcinogenesis. Determining the methylation status of genes in cancer and their association with clinical features play an essential role in early diagnosis, prognosis and determine appropriate treatment for patients. The purpose of the present study was to evaluate the methylation of tumor suppressor genes in patients with invasive ductal carcinoma (IDC). Furthermore, we evaluated the association between clinical parameters and DNA methylation as a biomarker in diagnostic IDC patients. The methylation-specific multiplex ligation dependent probe amplification (MS-MLPA) assay was used to analyze the methylation profile of 24 genes in formalin-fixed paraffin embedded (FFPE) tissue samples from 75 patients with IDC. Each of the patients showed a distinctive methylation profile. We observed higher methylation in the RASSF1 (48 %), CDH13 (44 %) and GSTP1 (36 %) genes. Some of the methylated genes were associated with clinical features. Methylation of GSTP1 (P=0.028) and RASSF1 (P=0.012) were related with lymph node metastasis. Methylation of GSTP1 (P=0.005) was associated with high histological grade. Moreover, concurrent methylation of GSTP1 and CDH13 was observed in IDC patients (p<0.001). Hierarchical cluster analysis based on the methylation profile revealed two main clusters of patients, the highly methylated cluster being significantly associated with high histological grade and lymph node metastasis. The results of this study indicate that the methylation status of RASSF1 and CDH13 and GSTP1 can be a prognostic marker to better management of IDC patients.
description: EXCLI Journal;Vol. 15, 2016
Next-to-soft corrections for Drell-Yan and Higgs boson rapidity distributions beyond N$^3$LO
Creators: name: Ajjath, A. H.
name: Mukherjee, Pooja
name: Ravindran, V.
name: Sankar, Aparna
name: Tiwari, Surabhi
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a formalism that sums up both soft-virtual (SV) and next to SV (NSV) contributions to all orders in perturbative QCD for the rapidity distribution of any colorless particle produced in hadron colliders. We have exploited the factorization properties and the renormalisation group (RG) invariance of the differential cross-section to achieve this. Using the state-of-the-art multiloop and multileg results, we determine the complete NSV contributions to third order in strong coupling constant for the rapidity distributions for a pair of leptons in Drell-Yan and also for Higgs boson in gluon fusion as well as bottom quark annihilation. Using the integral representation of our all order $z$ space result, we show how the NSV contributions can be resummed in two-dimensional Mellin space.
description: 6 Pages and 1 Table
The effect of ballast water on marine and coastal ecology of the Mediterranean Sea
Creators: name: Μαλισσόβας, Κωνσταντίνος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Ballast water
subject: Ballasting
subject: Marine and coastal ecology
subject: Mediterranean Sea

description: Η παρούσα διπλωματική εργασία εκπονήθηκε στα πλαίσια του Μεταπτυχιακού Προγράμματος «Shipping Management» του Πανεπιστημίου Πειραιώς. Ξεκινώντας, η έρευνα αυτή πραγματεύεται τον Ερματισμό, την έννοια του και τη χρησιμοποίηση κυρίως θαλάσσιου νερού για την επίτευξη επαρκής ευστάθειας των πλοίων. Στη συνέχεια, αναφέρονται οι επιδράσεις του θαλασσέρματος από τα παλαιότερα χρόνια μέχρι και σήμερα στο περιβάλλον και τον άνθρωπο. Πιο συγκεκριμένα, υπογραμμίζονται προβλήματα από παρεμβατικά είδη (invasive species) που μεταφέρονται από τον θαλάσσιο ερματισμό στη Μεσόγειο Θάλασσα και την θαλάσσια οικολογία της. Επιπροσθέτως, οι διεθνής κανονισμοί που έχουν θεσπιστεί από τον Παγκόσμιο Οργανισμό της Ναυτιλίας (IMO) αναλύονται εκτενέστατα με αναφορές στα νέα συστήματα διαχείρισης έρματος. Τέλος, αποτελέσματα ερευνών, στρατηγικές και μέτρα δράσης από περιφερειακούς οργανισμούς και μηχανισμούς της Μεσογείου παρατηρούνται και αναγνωρίζονται.
Geodesic networks in Liouville quantum gravity surfaces
Creators: name: Gwynne, Ewain
Publisher: name: arXiv
Year: 2020
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Recent work has shown that for $γ\in (0,2)$, a Liouville quantum gravity (LQG) surface can be endowed with a canonical metric. We prove several results concerning geodesics for this metric. In particular, we completely classify the possible networks of geodesics from a typical point on the surface to an arbitrary point on the surface, as well as the types of networks of geodesics joining two points which occur for a dense set of pairs of points on the surface. This latter result is the $γ$-LQG analog of the classification of geodesic networks in the Brownian map due to Angel, Kolesnik, and Miermont (2017). We also show that there is a deterministic $m\in\mathbb N$ such that almost surely any two points are joined by at most $m$ distinct LQG geodesics.
description: 40 pages, 10 figures; accepted to PMP
Incorporation of cobalt into ZnO nanoclusters
Creators: name: Ozerov, Igor
name: Chabre, Francoise
name: Marine, Wladimir
Publisher: name: arXiv
Year: 2005
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The structural, optical and magnetic properties of nanostructured ZnO films co-doped with cobalt and aluminium have been studied. The nanocrystalline films, with cluster sizes in range 50 - 100 nm, were deposited by pulsed laser ablation in a mixed atmosphere of oxygen and helium. The nanocrystallites have the wurtzite structure and are highly oriented with the c-axis perpendicular to the substrate. Both optical and electron spin resonance (ESR) spectroscopy results show the substitutional incorporation of Co$^{2+}$ ions on the Zn site inside the ZnO nanoclusters. The temperature dependence of the ESR spectra follows Curie law corresponding to a paramagnetic material.
Biologically-inspired machine learning approaches to large-scale neural data analysis
Creators: name: Hathway, Pamela
Publisher: name: Imperial College London
Year: 2020

description: Recent progress in recording techniques now allows researchers to record from hundreds and even thousands of neurons simultaneously. New, scalable methods need to be developed to handle such large data sets. Ideally these methods should not only analyse the multi-dimensional data, but also provide results which could be interpreted by the brain. One key problem in neuronal data analysis is to identify neuronal assemblies i.~e. groups of neurons displaying coordinated neuronal activity. Currently available methods either search for assemblies whose neurons participate in repeated spike sequences or search for assemblies whose neurons display similar firing rate modulations. In this thesis, I present two approaches to the search for neuronal assemblies. I investigate whether a spiking neural network equipped with biologically plausible synaptic learning rules can provide a biologically interpretable way of finding repeating spike patterns in neuronal data. Due to the similarities between spiking neural networks to how brains function, this might be very close to how the brain itself detects such repeated activity. Furthermore, I present neural topic modelling -- a new data analysis method for large neuronal data sets. Based on a machine learning method from text mining, neural topic modelling is scalable and produces interpretable results. By including multiple features of neuronal spike trains and even other data types such as local field potentials into the analysis, I can expand the definition of neuronal assemblies to any type of neuronal activity features which are co-modulated. The application of neural topic modelling to neuronal recordings reveals interactions between features of neuronal activity which have previously not been identified. Since both approaches are biologically plausible, the results from both methods can be used to generate hypotheses about how the brain processes information and may reveal hitherto unknown information processing pathways.
The arrow of time in operational formulations of quantum theory
Creators: name: Di Biagio, Andrea
name: Donà, Pietro
name: Rovelli, Carlo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The operational formulations of quantum theory are drastically time oriented. However, to the best of our knowledge, microscopic physics is time-symmetric. We address this tension by showing that the asymmetry of the operational formulations does not reflect a fundamental time-orientation of physics. Instead, it stems from built-in assumptions about the $users$ of the theory. In particular, these formalisms are designed for predicting the future based on information about the past, and the main mathematical objects contain implicit assumption about the past, but not about the future. The main asymmetry in quantum theory is the difference between knowns and unknowns.
description: 16 pages + references, a few diagrams. This version is to appear in Quantum. Title has changed, it used to be "Quantum information and the arrow of time''
Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents
Creators: name: Ravula, Parameshwar
name: Vamaraju, Harinadha Babu
name: Paturi, Manichandrika
name: Chandra, Narendra Sharath JN
name: Kolli, Swetha
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: Pyrazolyl tetrazole acetic acids
subject: antiproliferative activity
subject: molecular modeling
subject: VEGFR-2
subject: 610

description: A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 colon and PC-3 prostate cancer cell lines, and angioinhibitory activity in chorioallantoic membrane (CAM) model. Based on the obtained antiproliferative activity results of in vitro and CAM assay, compounds 4b, 4c, 4f, 5b, 5c and 5f were selected, and tested for anticancer activity using in vivo ehrlich ascites carcinoma (EAC) bearing mice. Compound 5c showed the highest in vitro antiproliferative activity against HT-29 and PC-3 with IC50 values of 6.43 μM and 9.83 μM respectively and comparable to reference drug Doxorubicin. Results of in vivo anticancer activity revealed that compound 5c showed the highest percentage increase in life span ( %ILS), and mean survival time (MST) with 75.13 % and 32.4 ± 0.53 days respectively. Moreover, compound 5c demonstrated significant reduction of microvessel density (MVD) in CAM assay. In silico prediction of toxicities, and drug score profiles of designed compounds are promising. A correlation made between the results obtained by antiproliferative study and molecular docking studies suggest that the synthesized compounds may be beneficial as molecular scaffolds for antiproliferative activity.
description: EXCLI Journal;Vol. 15, 2016
The ISO 170um Luminosity Function of Galaxies
Creators: name: Takeuchi, Tsutomu T.
name: Ishii, Takako T.
name: Dole, Herve
name: Dennefeld, Michel
name: Lagache, Guilaine
name: Puget, Jean-Loup
Publisher: name: arXiv
Year: 2005
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We constructed a local luminosity function (LF) of galaxies using a flux-limited sample (S_170 > 0.195Jy) of 55 galaxies at z < 0.3 taken from the ISO FIRBACK survey at 170um. The overall shape of the 170-um LF is found to be different from that of the total 60-um LF (Takeuchi et al. 2003): the bright end of the LF declines more steeply than that of the 60-um LF. This behavior is quantitatively similar to the LF of the cool subsample of the IRAS PSCz galaxies. We also estimated the strength of the evolution of the LF by assuming the pure luminosity evolution (PLE): L(z) \propto (1+z)^Q. We obtained Q=5.0^{+2.5}_{-0.5} which is similar to the value obtained by recent Spitzer observations, in spite of the limited sample size. Then, integrating over the 170-um LF, we obtained the local luminosity density at 170um, ρ_L(170um). A direct integration of the LF gives ρ_L(170um) = 1.1 \times 10^8 h Lsun Mpc^{-3}, whilst if we assume a strong PLE with Q=5, the value is 5.2 \times 10^7 h Lsun Mpc^{-3}. This is a considerable contribution to the local FIR luminosity density. By summing up with other available infrared data, we obtained the total dust luminosity density in the Local Universe, ρ_L(dust)=1.1 \times 10^8 h Lsun Mpc^{-3}. Using this value, we estimated the cosmic star formation rate (SFR) density hidden by dust in the Local Universe. We obtained ρ_SFR(dust) \simeq 1.1-1.2 h \times 10^{-2} Msun yr^{-1} Mpc^{-3}$, which means that 58.5% of the star formation is obscured by dust in the Local Universe.
description: A&A in press
Electron Spin-Lattice Relaxation of doped Yb3+ ions in YBa2Cu3Ox
Creators: name: Aminov, L. K.
name: Ivanshin, V. A.
name: Kurkin, I. N.
name: Gafurov, M. R.
name: Salikhov, I. Kh.
name: Keller, H.
name: Gutmann, M.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The electron spin-lattice relaxation (SLR) times T1 of Yb3+ ions were measured from the temperature dependence of electron spin resonance linewidth in Y0.99Yb0.01Ba2Cu3Ox with different oxygen contents. Raman relaxation processes dominate the electron SLR. Derived from the temperature dependence of the SLR rate, the Debye temperature (Td) increases with the critical temperature Tc and oxygen content x. Keywords: EPR; ESR; Electron spin-lattice relaxation; Debye temperature; Critical temperature
description: 5 Pages 4 Figures
Chemically synthesized CdSe quantum dots inhibit growth of human lung carcinoma cells via ROS generation
Creators: name: Jigyasu, Aditya Kumar
name: Siddiqui, Sahabjada
name: Lohani, Mohatashim
name: Khan, Irfan Ali
name: Arshad, Md
Publisher: name: Technische Universität Dortmund
Year: 2016
Subjects: subject: CdSe quantum dots
subject: transmission electron microscope
subject: A549
subject: reactive oxygen species
subject: DNA fragmentation
subject: 610

description: Quantum dots (QDs), semiconducting materials have potential applications in the field of electronic and biomedical applications including cancer therapy. In present study, cadmium selenide (CdSe) QDs were synthesized by chemical method. Octadecene was used as non-coordinating solvent which facilitated the formation of colloidal solutions of nanoparticles. CdSe QDs were characterized by UV-vis spectrometer and transmission electron microscope (TEM). The size measured by TEM was varied between 2-5 nm depending upon temperature. The cytotoxic activity of QDs was monitored by MTT assay, nuclear condensation, ROS activity and DNA fragmentation assay on human lung epithelial A549 cell line. Cells were treated with different concentrations of varying size of CdSe QDs for 24 h. CdSe QDs induced significant (p < 0.05) dose dependent cytotoxicity and this was comparable to the sizes of particles. Smaller particles were more cytotoxic to the large particles. Fluorescence microscopic analysis revealed that QDs induced oxidative stress generating significant ROS level and consequently, induced nuclear condensation and DNA fragmentation. Study suggested the cytotoxicity of CdSe QDs via ROS generation and DNA fragmentation depending upon particles size.
description: EXCLI Journal;Vol. 15, 2016
title: Improving Port State Control (PSC) performance using a risk-based approach: an in-depth literature review
title: Βελτιώνοντας την επίδοση των επιθεωρήσεων ελέγχου των Λιμενικών Αρχών (PSC) μέσω της προσέγγισης της διαχείρισης ρίσκου: μια σε βάθος βιβλιογραφική επισκόπηση
titleType: AlternativeTitle
Creators: name: Βεντούρης, Ιάκωβος-Μάριος
name: Ventouris, Iakovos-Marios
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Port State Control (PSC)
subject: Performance
subject: Risk factors
subject: Paris MoU

description: Κατά τις τελευταίες δεκαετίες, η οικονομική συμβολή των θαλάσσιων μεταφορών στη ναυτιλιακή βιομηχανία αυξήθηκε ραγδαία. Αυτή είναι μια θετική τάση, αλλά συνεπάγεται πολλές απειλές (π.χ. απώλειες ανθρώπινων ζωών, περιβαλλοντικές απειλές, θαλάσσια ρύπανση κ.λπ.) για τη ναυτιλιακή βιομηχανία. Ως εκ τούτου, έχει δημιουργηθεί ένα ευρύ φάσμα θαλάσσιων μέτρων με στόχο την εξάλειψη των απειλών που απειλούν την ασφάλεια στη θάλασσα. Μεταξύ αυτών των μέτρων περιλαμβάνονται οι επιθεωρήσεις ελέγχου στα λιμάνια. Από την υπογραφή του Μνημονίου της Χάγης το 1978, ο έλεγχος στα λιμάνια αποτελεί μία στρατηγική, η οποία εφαρμόζεται παγκοσμίως, με στόχο την αποκατάσταση ή την απόσυρση των πλοίων που δεν πληρούν συγκεκριμένα ασφάλειας. Λαμβάνοντας υπόψη τη σημασία της αύξησης της απόδοσης των επιθεωρήσεων στα λιμάνια, η παρούσα Διπλωματική συνιστά μια εις βάθος ανασκόπηση της βιβλιογραφίας, η οποία στοχεύει στον εντοπισμό των μεθόδων κινδύνων οι οποίες προτείνονται στη διεθνή βιβλιογραφία για τη βελτίωση της απόδοσης του του ελέγχου στα λιμάνια. Επιπλέον, αυτή η έρευνα στοχεύει στον εντοπισμό των παραγόντων που επηρεάζουν τις επιθεωρήσεις στα λιμάνια με βάση τα ευρήματα της διεθνούς βιβλιογραφίας. Το δείγμα αυτής της βιβλιογραφικής επισκόπησης είναι ακαδημαϊκά άρθρα που έχουν δημοσιευτεί σε περιοδικά υψηλής ποιότητας τα τελευταία 20 χρόνια. Κατά τη διαδικασία συλλογής δευτερογενών δεδομένων εντοπίστηκαν συνολικά 28 άρθρα που προτείνουν μεθοδολογικές προσεγγίσεις κινδύνου (risk based approaches) για τη βελτίωση της απόδοσης των επιθεωρήσεων στα λιμάνια. Επιπλέον, εντοπίστηκαν συνολικά 19 άρθρα που εξέταζουν τους παράγοντες που επηρεάζουν την απόδοση των επιθεωρήσεων στα λιμάνια. Τα αποτελέσματα της έρευνας, έδειξαν ότι τα περισσότερα από τα επιλεγμένα επιστημονικά άρθρα επικεντρώνονται στην μέθοδο κινδύνου που είναι γνωστή ως «Bayesian δίκτυα». Λιγότερες μελέτες έχουν δημοσιευτεί πάνω σε άλλες προσεγγίσεις όπως η μέθοδος «μηχανική διανυσματικής υποστήριξης (Support Ventor Machine Approach), η μέθοδος «Bayesian δίκτυα σε συνδυασμό με τη θεωρία παιγνίων (game theory) και η μέθοδος K-nearest neighbor. Όσον αφορά στους παράγοντες, οι οποίοι επηρεάζουν την απόδοση των επιθεωρήσεων στα λιμάνια, τα αποτελέσματα της έρευνας έδειξαν ότι τα 17 από τα 19 επιστημονικά άρθρα, που εξετάστηκαν στο πλαίσιο της παρούσας Διπλωματικής, εστιάζουν στους ακόλουθους παράγοντες: την ηλικία του πλοίου, τη σημαία του πλοίου, το ιστορικό επιθεωρήσεων και την κοινωνία ταξινόμησης (classification society).
Lattice gauge equivariant convolutional neural networks
Creators: name: Favoni, Matteo
name: Ipp, Andreas
name: Müller, David I.
name: Schuh, Daniel
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: Machine Learning (cs.LG)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Machine Learning (stat.ML)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We propose Lattice gauge equivariant Convolutional Neural Networks (L-CNNs) for generic machine learning applications on lattice gauge theoretical problems. At the heart of this network structure is a novel convolutional layer that preserves gauge equivariance while forming arbitrarily shaped Wilson loops in successive bilinear layers. Together with topological information, for example from Polyakov loops, such a network can in principle approximate any gauge covariant function on the lattice. We demonstrate that L-CNNs can learn and generalize gauge invariant quantities that traditional convolutional neural networks are incapable of finding.
description: letter: 6 pages, 5 figures; supplementary material: 14 pages, 4 figures; replaced some figures, added supplementary material
ETHNICISED ENTITLEMENTS? PROPERTY RIGHTS AND CIVIL WAR IN SRI LANKA
Creators: name: Korf, Benedikt
name: Korf, Benedikt
Publisher: name: Unknown
Year: 2003
Subjects: Political Economy
Resource /Energy Economics and Policy

description: The present paper investigates how ethnic violence and civil war in Sri Lanka have affected local property rights institutions . I use local case studies to analyze the institutional relations and alliances between civilians and combatants in the emergent society of violence that shapes local communities in civil war. My focus will be on how civilians from different ethnic groups utilize social and political capital assets to secure entitlements to natural resources. The findings of my research suggest that resource entitlements in Trincomalee are "ethnicised" in the sense that opportunities and access to resources are unequally distributed among the three ethnic groups (Sinhalese, Tamils, Muslims), because these groups are unequally endowed with political capital. Patron-client networks based on ethnicity shape the relative bargaining power of local actors. This system reproduces perceived grievances among the different ethnic groups and thus reproduces the conditions for ethnic violence.
Triviality of Bloch and Bloch-Dirac bundles
Creators: name: Panati, Gianluca
Publisher: name: arXiv
Year: 2006
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81Q70; 53C07; 53C80

description: In the framework of the theory of an electron in a periodic potential, we reconsider the longstanding problem of the existence of smooth and periodic quasi-Bloch functions, which is shown to be equivalent to the triviality of the Bloch bundle. By exploiting the time-reversal symmetry of the Hamiltonian and some bundle-theoretic methods, we show that the problem has a positive answer for any d < 4, thus generalizing a previous result by G. Nenciu. We provide a general formulation of the result, aiming at the application to the Dirac equation with a periodic potential and to piezoelectricity.
description: 20 pages, no figures
Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling
Creators: name: Yang, Wei
name: Burkhardt, Britta
name: Fischer, Luise
name: Beirow, Maja
name: Bork, Nadja
name: Wönne, Eva C.
name: Wagner, Cornelia
name: Husen, Bettina
name: Zeilinger, Katrin
name: Liu, Liegang
name: Nussler, Andreas K.
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: aging
subject: liver
subject: antioxidant
subject: Akt
subject: MAPKs
subject: cell proliferation
subject: 610

description: Aging is characterized by a progressive decrease of cellular functions, because cells gradually lose their capacity to respond to injury. Increased oxidative stress is considered to be one of the major contributors to age-related changes in all organs including the liver. Our study has focused on elucidating whether important antioxidative enzymes, the mTOR pathway, and MAPKs exhibit age-dependent changes in the liver of rats during aging. We found an age-dependent increase of GSH in the cytosol and mitochondria. The aged liver showed an increased SOD enzyme activity, while the CAT enzyme activity decreased. HO-1 and NOS-2 gene expression was lower in adult rats, but up-regulated in aged rats. Western blot analysis revealed that SOD1, SOD2, GPx, GR, γ-GCL, and GSS were age-dependent up-regulated, while CAT remained constant. We also demonstrated that the phosphorylation of Akt, JNK, p38, and TSC2Ser1254 decreased while ERK1/2 and TSC2Thr1462 increased agedependently. Furthermore, our data show that the mTOR pathway seems to be activated in livers of aged rats, and hence stimulating cell proliferation/regeneration, as confirmed by an age-dependent increase of PCNA and p-eIF4ESer209 protein expression. Our data may help to explain the fact that liver cells only proliferate in cases of necessity, like injury and damage. In summary, we have demonstrated that, age-dependent changes of the antioxidant system and stress-related signaling pathways occur in the livers of rats, which may help to better understand organ aging.
description: EXCLI Journal;Vol. 14, 2015
Quantum oscillator noise spectroscopy via displaced cat states
Creators: name: Milne, Alistair R.
name: Hempel, Cornelius
name: Li, Li
name: Edmunds, Claire L.
name: Slatyer, Harry J.
name: Ball, Harrison
name: Hush, Michael R.
name: Biercuk, Michael J.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum harmonic oscillators are central to many modern quantum technologies. We introduce a method to determine the frequency noise spectrum of oscillator modes through coupling them to a qubit with continuously driven qubit-state-dependent displacements. We reconstruct the noise spectrum using a series of different drive phase and amplitude modulation patterns in conjunction with a data-fusion routine based on convex optimization. We apply the technique to the identification of intrinsic noise in the motional frequency of a single trapped ion with sensitivity to fluctuations at the sub-Hz level in a spectral range from quasi-DC up to 50 kHz.
Comments on the D-instanton calculus in (p,p+1) minimal string theory
Creators: name: Fukuma, Masafumi
name: Irie, Hirotaka
name: Seki, Shigenori
Publisher: name: arXiv
Year: 2005
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The FZZT and ZZ branes in (p,p+1) minimal string theory are studied in terms of continuum loop equations. We show that systems in the presence of ZZ branes (D-instantons) can be easily investigated within the framework of the continuum string field theory developed by Yahikozawa and one of the present authors (hep-th/9609210). We explicitly calculate the partition function of a single ZZ brane for arbitrary p. We also show that the annulus amplitudes of ZZ branes are correctly reproduced.
description: 21 pages, 1 figure, final version
DO DEMOCRACY AND PRESS FREEDOM REDUCE CORRUPTION? EVIDENCE FROM A CROSS COUNTRY STUDY
Creators: name: Chowdhury, Shyamal K.
name: Chowdhury, Shyamal K.
Publisher: name: Unknown
Year: 2004
Subjects: Political Economy

description: This paper calls attention to the instrumental role of democracy and press freedom in combating corruption. As opposed to an autocracy with no or limited press freedom, a free press in a democracy can inform voters about the corruption of political representatives, and voters in turn can punish incumbents by electing opposition parties. The empirical investigation carried out in this paper shows that democracy and press freedom can have significant impact on corruption. Though corruption may persist in the short- to medium-run, an increase in voters' participation and press freedom can reduce corruption.
RETHINKING THE BRAIN DRAIN
Creators: name: Stark, Oded
name: Stark, Oded
Publisher: name: Unknown
Year: 2003
Subjects: Labor and Human Capital

description: When productivity is fostered by both the individual's human capital and by the average level of human capital in the economy, individuals under-invest in human capital. A strictly positive probability of migration to a richer country, by raising both the level of human capital formed by optimizing individuals in the home country and the average level of human capital of non-migrants in the country, can enhance welfare and nudge the economy toward the social optimum. Under a well-controlled restrictive migration policy the welfare of all workers is higher than in the absence of this policy.
Ποιοτική αξιολόγηση της απόδοσης της αλυσίδας εφοδιασμού: μελέτη περιπτώσεων εταιρειών κλάδου ένδυσης
Creators: name: Παπαγεωργίου, Αικατερίνη
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2020
Subjects: subject: Απόδοση αλυσίδας εφοδιασμού
subject: Εταιρείες ένδυσης
subject: Στρατηγική γρήγορης μόδας
subject: Zara
subject: Benetton
subject: H&M

description: Στην σημερινή εποχή του έντονου ανταγωνισμού και της παγκοσμιοποίησης, η σημασία που αποκτά για τις επιχειρήσεις η διαχείριση της αλυσίδας εφοδιασμού είναι όλο και μεγαλύτερη προκειμένου να επιτευχθεί ο διπλός στόχος της βελτίωσης της εξυπηρέτησης του πελάτη με το χαμηλότερο δυνατό κόστος. Οι επιχειρήσεις λιανικού εμπορίου και κυρίως αυτές του χώρου της μόδας αντιμετωπίζουν συνεχείς αλλαγές και μεγάλη αβεβαιότητα με αποτέλεσμα να επιβιώνουν και να διατηρούν το μερίδιο τους στην αγορά μόνο όσες καταφέρνουν να προσαρμόζονται γρήγορα και ευέλικτα στα δεδομένα και τις προκλήσεις που διαμορφώνονται. Οι υπόλοιπες απλά εξαφανίζονται. Η ολοκλήρωση εσωτερικά αλλά και ανάμεσα στις λειτουργίες που τυπικά εκτελούνται σε μία αλυσίδα εφοδιασμού είναι το κλειδί για την επιβίωση και ανάπτυξη των επιχειρήσεων, κάτι το οποίο έχει γίνει πλέον έντονα αντιληπτό από τον ευρύτερο επιχειρηματικό κόσμο. Σύμφωνα λοιπόν με τα παραπάνω, βασικός σκοπός της συγκεκριμένης εργασίας είναι η παρουσίαση, ανάλυση και αξιολόγηση μέσα από την μελέτη περιπτώσεων (case studies) πρακτικών αποδοτικής διαχείρισης της αλυσίδας εφοδιασμού. Λίγες αλυσίδες εφοδιασμού είναι εξίσου δυναμικές με αυτές που επικαλείται η βιομηχανία της μόδας, γι’ αυτό και οι εταιρείες που επελέγησαν να μελετηθούν προέρχονται από τον κλάδο της ένδυσης. Η Zara, η Benetton και η H&M είναι από τις πλέον επιτυχημένες και αποδοτικές εταιρείες του κλάδου που εξειδικεύονται στην στρατηγική της γρήγορης μόδας χαρακτηριστικό της οποίας είναι η «γρήγορη ανταπόκριση» στις απαιτήσεις του πελάτη. Είναι φανερό λοιπόν ότι η αλυσίδα εφοδιασμού κάθε μίας εκ των αναφερόμενων επιχειρήσεων είναι υψίστης σπουδαιότητας και παίζει σημαντικό ρόλο στη μείωση των χρόνων απόκρισης καθώς και του χρόνου που απαιτείται για να φτάσει ένα προϊόν από την παραγωγή στο σημείο λιανικής πώλησης και εντέλει στον τελικό καταναλωτή. Ως εκ τούτου η παρουσίαση και η συγκριτική ανάλυση της οργάνωσης, των ενεργειών και των καινοτόμων πρακτικών που εφάρμοσαν στην διαχείριση της αλυσίδας εφοδιασμού τους πέρα του ιδιαίτερου ενδιαφέροντος που παρουσιάζει ως αντικείμενο μελέτης είναι και ένα εξαιρετικό εργαλείο αντιμετώπισης προκλήσεων και εξάλειψης προβλημάτων που παρουσιάζουν επιχειρήσεις του κλάδου αλλά και εν γένει, το οποίο αποτελεί και το συνολικό αποτέλεσμα της εργασίας.
A genetically immortalized human stem cell line: a promising new tool for Alzheimer's disease therapy
Creators: name: Puangmalai, Nicha
name: Somani, Alyma
name: Thangnipon, Wipawan
name: Ballard, Clive
name: Broadstock, Martin
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: Alzheimer’s disease
subject: cell viability
subject: CTX0E03 cell line
subject: neural stem cell
subject: okadaic acid
subject: oligomeric amyloid-β
subject: 610

description: Amyloid-β peptides and hyper-phosphorylated tau are the main pathological hallmarks of Alzheimer’s disease (AD). Given the recent failure of several large-scale clinical trials and the lack of disease-modifying pharmacological treatments, there is an urgent need to develop alternative therapies. A clinical grade human CTX0E03 neural stem cell line has recently passed phase I trials in people with stroke. However, this cell line has not been investigated in other neurodegenerative disorders. This study investigates the survival of CTX0E03 cells under conditions based on the underlying AD pathology. Cell viability assays showed a concentration dependence of this cell line to the toxic effects of Aβ1-42, but not Aβ1-40, and okadaic acid, a phosphatase 2A inhibitor. Notably, CTX0E03 cell line displayed toxicity at concentrations significantly higher than both rat neural stem cells and those previously reported for primary cultures. These results suggest CTX0E03 cells could be developed for clinical trials in AD patients.
description: EXCLI Journal;Vol. 14, 2015