cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Thiazolidin-4-one derivatives as antitumor agents against (Caco-2) cell line: synthesis, characterization, in silico and in vitro studies
Creators: name: Saad, Salwa S
name: El-Sakka, Sahar S. A.
name: Soliman, M. H. A.
name: Gadelmawla, Mohamed H. A.
name: Mahmoud, Nashwa M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Compounds based on thiazolidinones have drawn particular attention in the field of medicinal chemistry as potential sources of novel drug-like molecules. In this study thiazolidin-4-one derivatives (3–17) were prepared by refluxing a mixture of β-aroylacrylic acid (1) and aryl thiosemicarbazone (2) and characterized using IR and 1H NMR spectroscopy. In silico, physicochemical descriptors and pharmacokinetic properties were assessed using the SwissADME web tool. Moreover, docking studies of synthesized compounds were performed in order to explore their binding to cyclooxygenase-2 (COX-2) (PDB code: 5IKT) and p53 (PDB code: 6MXZ). Some synthesized compounds were evaluated for their in vitro cytotoxic activity against colon cancer (Caco-2) cell line. Among the tested compounds, compound (16) showed a higher effect with (IC50 of 70 µg/ml). The synthesized compounds revealed reduced Caspase-3 and p53 gene expression, suggesting the potential antineoplastic effects of these compounds.
Missa : [d-Moll] : [für Soli, gemischten Chor und Orchester]
Creators: name: Naumann, Johann Gottlieb
name: Fröhlich, Friedrich Theodor
Publisher: name: [s.n.]
Year: 1828

description: [Johann Gottlieb Naumann]
description: a) Partitur. Akz.Nr.: *27.932
description: b) Alt-Solostimme. Akz.Nr.: *54,1017
description: c) Bass-Solostimme. Akz.Nr.: *54,1017
description: d) Tenor-Tuttistimme. Akz.Nr.: *54,1017
description: e) Offertorium. Tenorstimme. Akz.Nr.: *54,1017. (4 Ex.)
description: Partitur datiert: Berlin 26.II.28
description: Vermerk auf den Stimmen: Missa von Th. Fröhlich, Nro. II
description: Dieses Werk galt lange als Komposition von Friedrich Theodor Fröhlich. Seit 2000 (Vergleich der Partituren) ist klar, dass es sich um eine Abschrift der "Missa d-Moll" (Nr. 18) von Johann Gottlieb Naumann (komponiert 1794) handelt, die kleine Änderungen von Fröhlich enthält
description: Geschenk 1927 ; 1954 Verschiedene Akz.Nr. Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Tschupp, Räto. - Eine Messe - zwei Komponisten? In: SLUB-Kurier ; Jg. 15(2001), Nr. 4, S. 12-14
description: Meyer, Thomas. - Johann Gottlieb Naumann und Theodor Fröhlich. In: Schweizer Musikzeitung ; Jg. 5(2002),Nr. 9, S. 9-10
description: Sarbach, Pierre. - Es irrt der Mensch, so lang er lebt. In: Schweizer Musikzeitung ; Jg. 6(2003), Nr. 7/8, S. 15-16
description: Teil e) früher als kr XI 3a signiert (06.12.2011/A100/JPL)
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation März 2024 TIFF
Poema Rauricum oder, der Sach vnd Weis halb, gantz Newes, Teutsches, Heroisches Versgedicht: Von des jungen Ritters Fidamoris, vnd Schäfers Erotandri, bey den vhralten Raurachern, Nachbarn, vnd andern Völckern, lob- vnd liebreichen Verhaltungen, 1658
Creators: name: Brandmüller, Johannes
Publisher: name: [s.n.]
Year: 1658

description: Die Hs. enthält den ersten Teil des epischen Gedichts: Sequania (6 Bücher), während ein zweiter Teil: Germania (6 weitere Bücher) verschollen ist oder nie als Reinschrift vorlag, vgl. die Edition der Titelseite (1r) sowie der Inhaltsangabe (1v-4v) bei Kleinschmidt, S. 11 resp. 46-55. Der Autograph mit dem umfangreichen "Vortrab" dazu (vgl. 5r), eine Hs. kleineren Formats, aber mit vollkommen entsprechender Einrichtung, befindet sich in Stuttgart: Donaueschingen 135, vgl. zu den beiden Hss. und ihrer Provenienz etc. Kleinschmidt, S. 10-15.
description: Johannes Brandmüller (1593-1664)
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Kleinschmidt, Erich. - Stadtbürgertum und späthumanistische Gelehrtenkultur. Johannes Brandmüllers (1593-1664) Versuch einer heroischen Epik in deutschen Hexametern, in: Jahrbuch der deutschen Schillergesellschaft, 22 (1978), S. 1-55.
description: Verzeichnung=Description=Inventaire Dez. 2009 Titel, Jahr und Signatur nach: Steinmann, Inventar, 1970
description: Verzeichnung=Description=Inventaire April 2024 Ergänzungen nach Autopsie Mangold
description: Digitalisierung=Digitization=Numérisation April 2024 TIFF
description: Erschliessungsniveau Minimalniveau
description: Stuttgart, Württembergische Landesbibliothek, Cod. Don. 135
A ratiometric fluorescent probe based on phenothiazine and quinazolinone for rapid detection of ClO− and its application
Creators: name: Zhang, Cheng-lu
name: Guo, Jing-hao
name: Zhang, Yang
name: Zhang, Lu
name: Liu, Chang
name: Nie, Shi-ru
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: A novel fluorescent probe (BPQ-1) with large conjugated system (phenothiazine was conjugated with quinazolinone) was synthesized. BPQ-1 showed a remarkable ratiometric fluorescence response to ClO− within 10 s, and achieved large stokes shift (168 nm), high sensitivity (LOD = 16.7 nM) and excellent selectivity. Among the analytes to be detected, there is a significant change from bright yellow fluorescence to cyan fluorescence only when ClO− is added to BPQ-1. Through density functional theory calculation and mass spectrometry experiments, the fluorescence response mechanisms of the BPQ-1 are given. In addition, BPQ-1 has been successfully applied to the detection of ClO− in real water samples and test strips for detecting ClO− with different concentrations have been prepared. In particular, the probe has been successfully applied to the fluorescence imaging of exogenous ClO− in living cells.
Synthesis of new 1,2,3-triazole-linked pyrimidines by click reaction
Creators: name: Cheldavi, Forough
name: Bakherad, Mohammad
name: Keivanloo, Ali
name: Nikpour, Mohsen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: A mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazole linked pyrimidines is reported using click reactions. These compounds were prepared by the reaction of 4-propargyl substituted 5-iodo-6-methyl-2(methylthio) pyrimidine with aryl and benzyl azides via copper-catalyzed azide-alkyne cycloaddition reactions in the presence of sodium ascorbate, as a reducing agent. Furthermore, the synthesized compounds were screened against the two bacterial strains pseudomonas aeruginosa and saphylococcus aureus.
Synthesis and application of Fe3O4@RHA nanocatalyst in the synthesis of polyhydroquinolines and dihydropyrimidinones (statistical approach to optimize parameters)
Creators: name: Shahbazarab, Zeinab
name: Nasr-Esfahani, Masoud
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology

description: In this study, rice husk ash as silica source was obtained and then, by adding Fe3O4, Fe3O4@RHA core-shell nanocatalyst was prepared. The Fe3O4@RHA nanocatalyst was identified using VSM, XRD, FE-SEM, EDX, and FT-IR analysis, and the optimization of the effective parameters in the reaction was done using response surface methodology (RSM). This nanocatalyst had spherical particles with an average particle size of about 30 nm and good magnetic properties of about 42 emu/gr. The Fe3O4 particles encapsulated in RHA were easily recovered and showed good catalytic activity. Using Fe3O4@RHA biosynthesized nanocatalyst, polyhydroquinoline derivatives were obtained through multi-component condensation of ammonium acetate, aldehyde, ethyl acetoacetate, and dimedone, under solvent-free conditions at 80 °C, as well as dihydropyrimidinone derivatives through multi-component reactions by condensation of urea, aromatic aldehyde, and β-Keto ester under solvent-free conditions at 70 °C. Fe3O4@RHA nanocatalyst was introduced as a heterogeneous, stable, and environmentally compatible catalyst; in its production, dangerous materials, reagents, and solvents were avoided and it is environmentally friendly. In addition, it has the advantage of being recyclable, resulting in short reaction time, high product yield, and economically good performance.
A promising α-amylase inhibitor based on the 2-(2-hydrazinyl) thiazole scaffolds: synthesis, docking studies and biological evaluation
Creators: name: Raut, Dattatraya
name: Bhosale, Dnyandev
name: Bhosale, Raghunath
name: Lawand, Anjana
name: Hublikar, Mahesh
name: Nirmal, Shraddha
name: Dhadake, Shailaja
name: Chaudhari, Praffula
name: Deshmukh, Sandip
name: Hiwarale, Dipak
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: A series of novel hydrazinyl-based thiazole scaffolds were designed, synthesized, and evaluated for their anti-diabetic activity. The cyclocondensation reaction of the appropriately substituted acetophenones 1, thiosemicarbazide 2, and appropriate phenacyl bromide 3 allowed for the creation of a new series of hydrazinyl-based thiazole scaffolds (4a–h). The newly generated compounds were characterized using mass spectrometry,1H NMR, IR, and 13C NMR techniques. The novel hydrazinyl-based thiazole scaffolds were evaluated by the in vitro α-amylase inhibitory assay. Hydrazinyl-based thiazole scaffolds 4a, 4b, 4d, and 4f showed good activity compared to acarbose as a standard reference. Although insulin is a necessary medication for the treatment of diabetes, it carries a significant risk. We believe that thiazole scaffolds based on hydrazinyl structural motive provide recommendations for designing and producing novel anti-diabetic drugs, which are critically needed. Moreover, these compounds show a strong affinity for the pancreatic α-amylase protein binding site, suggesting greater inhibitory capability at the cellular level, and molecular docking studies have demonstrated their better-fit potential as anti-diabetic agents. This indicates the versatility of the hydrazinyl-based thiazole molecules to achieve new classes of anti-diabetic scaffold.
Preyssler heteropolyacid-mediated direct deprotection/N-benzoylation of N-Boc-protected sulfonamides: synthesis, molecular docking, DFT study and in-silico ADME evaluation of novel benzamides bearing the sulfonamide moiety as possible inhibitors of human carbonic anhydrase II
Creators: name: Bouskia, Soumaya
name: Bougheloum, Chafika
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: An adequate method is described for the synthesis of new substituted benzamides containing a sulfonamide moiety using Preyssler heteropolyacid H14[NaP5W30O110] as an efficient catalyst. This method proceeds in one-step, including deprotection and benzoylation of N-(tert-butoxycarbonyl) sulfonamides to give the target compounds good yields (up to 92%). A molecular docking was performed to study the interactions between the synthesized benzamides and human carbonic anhydrases II. It was concluded that all compounds demonstrated good binding score values (up to −9.4 kcal/mol) for the active site of all selected proteins when compared with the reference drug Acetazolamide (−6.3 kcal/mol). In addition, the ADME/T analyses show that all synthesized molecules exhibited good pharmacokinetics and bioavailability. The theoretical calculations for all compounds were performed using the DFT/B3LYP/6–31G (d,p) level of theory. The study yielded optimized structural parameters, global reactivity descriptors, and Frontier Molecular Orbitals (FMO’s).
Pyrimidine appended heterocycles: synthesis, characterization, and biological evaluation
Creators: name: Basavanna, Vrushabendra
name: Basavaraj, Siddesh M.
name: Ramegowda, Manjunatha C.
name: Bhadraiah, Umesha K
name: Manasa, Chandramouli
name: Gurudatt, Doddahosuru M.
name: Ningaiah, Srikantamurthy
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A new class of pyrimidine-based heterocycles has been successfully synthesized via a simple and efficient way starting from 2-keto-thiophene (1). The α,β-unsaturated ketone (chalcone) (3) was first synthesized by treating the ketone (1) with 4-methoxy benzaldehyde (2), followed by treating with amino formamidine hydrochloride to afford the intermediate pyrimidine moiety (4) which was converted to amide functionalized pyrimidines (5a–e), pyrimidine-2-imines (6a–e) and thiophene tethered pyrimidine-imidazoles (7a–e). The structures assigned to the new compounds are confirmed by IR, NMR, and MS studies. The newly synthesized compounds were subjected to a molecular docking study with the protein of Staphylococcus aureus (PDB ID: 1JIJ), for antioxidant and antibacterial activity. The compounds 5a, 6a, 6b, and 7d were found to show hydrogen bond interaction with active site amino acid residues with the binding energy of −8,08, −8.39, −8.64, and −8.02 kJ/mol, respectively, and may act as potential inhibitors of bacterial tyrosyl-tRNA synthetases. The biological study envisioned that the synthesized compound 7b has shown potent antioxidant properties with 74.07% scavenging activity at 400 µg/mL and compound 6b was found to exhibit excellent antibacterial activity with 16, 20, 21, and 22 mm zone of inhibition against S. aureus, Escherichia coli, Salmonella paratyphi-A and Bacillus subtilis bacterial strains, respectively.
The impact of hetero-aromatic rings on optoelectronic and charge transport properties of fused polycyclic compounds
Creators: name: Verma, Pankaj
name: Kumar, Vipin
name: Chetti, Prabhakar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The structural, optoelectronic, and charge-transport properties of linearly fused polycyclic hydrocarbon molecules with heteroatoms (NH, O, S, and Se) in five-membered rings have been investigated using the DFT approach. The hybrid functional B3LYP in combination with the 6–311 + G (d,p) basis set is utilized in the Gaussian 16 W software package for all the calculations. The absorption and emission energies are investigated by using time-dependent density functional theory (TD-DFT) at the same level of theory. To investigate the stability of each molecule concerning its aromaticity, nucleus-independent chemical shift (NICS) values are computed. Electron affinity (EA), hole extraction potential (HEP), ionization potential (IP), and electron extraction potential (EEP) are also reported. The simulated hole (λh) and electron (λe) reorganization energies for the majority of the molecules are lower than the characteristics hole and electron-transporting materials. The reported fused polycyclic compounds may have potential applications in optoelectronic devices.
Nano Fe3O4 catalyzed selective, tandem, and oxidative conversion of alcohols, tetrahydropyranyl and trimethylsilyl ethers to oximes
Creators: name: Mohamadian, Samaneh
name: Aghapour, Ghasem
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: Tandem and efficient conversion of alcohols, tetrahydropyranyl (THP) and trimethylsilyl (TMS) ethers as protected alcohols to oximes is described using a catalytic amount of nano Fe3O4 as a highly magnetic and nontoxic catalyst, tert-butyl hydroperoxide (TBHP) and hydroxylamine hydrochloride. The nanocatalyst is easily separated from the reaction medium using an external magnet and can be reused for several times without any considerable loss of its catalytic power. Also, it was found that it is possible to perform these oxidative conversions efficiently even in the presence of epoxides, carboxylic acids and esters, phenols, sulfides and pyridine rings with excellent chemoselectivity. The tandem and catalytic nature, catalyst reusability, high yields, and easy work up can be considered as the main advantages of the present environmentally friendly method.
Efficient synthesis of halobenzothioamides from the hydrosulfuration of halobenzonitriles and mechanism investigation
Creators: name: Chen, Juan
name: Li, Shanshan
name: Hong, Hailong
name: Jia, Huijie
name: Zhu, Ning
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Physical Sciences not elsewhere classified
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: An efficient method for the synthesis of various halobenzothioamides from the hydrosulfuration of a variety of halobenzonitriles with NaHS under mild conditions was developed by adding auxiliary reagent MgCl2 · 6 H2O. It was found that an excellent yield of benzothioamides is obtained from the hydrosulfuration of halobenzonitrile with inorganic sulfur reagents by adjusting the pH value of the reaction solution. Reaction condition optimization experiments revealed, that high yields of products were obtained in the pH range of 8–10.
Synthesis of some new transition metal complexes derived from tellurated formazanes
Creators: name: Naji, Amenah D.
name: Al-Fregi, Adil A.
name: Al-Riyahee, Ali A. A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: A novel series of organotellurium compounds based on formazane derivatives with a general formula of ArTeBr3 4 and Ar2TeBr2 5 [Ar = 2-[{4-hydroxy-3-methoxyphenyl}{4-nitrophenyldiazenyl}methylene amino]-5-nitrophenyl] were synthesized by refluxing mercurated formazane derivative ArHgCl with TeBr4 in two different mole ratios of 1:1 and 2:1, respectively, in dry dioxane solvent under an argon atmosphere. Compounds ArTeBr3 and Ar2TeBr2 were then reduced by the action of an ethanolic solution of hydrazine hydrate to obtain Ar2Te2 6 and Ar2Te 7, respectively. The ligand properties of bis(2-[{4-hydroxy-3-methoxy phenyl}{4-nitrophenyl diazenyl}methylene amino]-5-nitrophenyl) telluride (7) were examined toward several metal ions through its reaction with K2PtCl4, PdCl2 · 2 H2O, K2PtCl6, RhCl3 · 3 H2O, CoCl3 · 6 H2O and NiCl2, respectively. These compounds were characterized by FTIR, UV-Vis,1H and 13C{1H} NMR spectroscopy and mass spectrometry as well as by elemental analysis, thermal analysis, magnetic susceptibility and molar conductivity. The identification of the synthesized complexes 8-13 proved that the complexes of Pt(II), Pd(II) and Ni(II) have square pyramidal geometries and are diamagnetic, while the complexes of Pt(IV), Rh(III) and Co(III) have octahedral shapes with the same magnetic behavior. The telluride 7 behaves as a neutral pentadentate ligand.
Ultrasound-assisted, copper-catalyzed S-arylation of nitro compounds-heterocumulene adducts
Creators: name: Nematpour, Manijeh
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Molecular Biology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer

description: S-Arylation of nitro compounds-heterocumulene adducts with CuI as the catalyst, K2CO3 as the base, and highly efficient was successfully implemented without the help of an additional ligand under ultrasound irradiation in MeCN at room temperature. The use of simple and readily available starting materials, no need for column chromatography, mild copper-catalytic reaction conditions, good yields (70–89%), application of the sonochemical methodology, and short reaction times are remarkable specifications of this protocol.
title: novinki präsentiert: Cultural producers in the ‘post-soviet’ region facing the Covid-19 pandemic – a serie of online workshops: Maria Stepanova im Gespräch mit Kulturschaffenden aus Lettland, Kirgistan, Armenien, Georgien, Belarus und der Ukraine
Creators: name: :None
Publisher: name: Fachinformationsdienst Slavistik
Year: 2020
Subjects: subject: Lettland
subject: Kirgistan
subject: Armenien
subject: Georgien
subject: Belarus
subject: Ukraine
subject: Kulturelle Entwicklung
subject: Künstler
subject: Postkolonialismus
subject: 20. - 21. Jahrhundert
subject: Interview
subject: 491.8

description: Auf Initiative des Fachgebiets für Ostslawische Literaturen und Kulturen fanden im Oktober 2020 unter Leitung von Maria Stepanova (Siegfried Unseld Gastprofessorin 2018-19) im Zoom der Humboldt Universität vier Workshops statt, deren Ziel es war, die Landschaft der Kulturinstitutionen und künstlerischen Entwicklungen in einigen Ländern, ehemaligen Sowjetrepubliken, in Hinblick auf ihre aktuelle Situation – auch im Kontext der Covid-19 Pandemie – zu kartieren, institutionelle und künstlerische Entwicklungen der letzten Jahre zu analysieren und ihre Zukunftsperspektiven auch mit Blick auf Fördermöglichkeiten für unabhängige künstlerische und kuratorische Perspektiven zu erörtern.
description: novinkinachgegangen
Versatile synthesis of 2-functionalized dihydrothiazolo[2,3-b]quinazolines through regioselective electrophilic intramolecular heterocyclization of 3-alkenyl-2-thioxoquinazolin-4-ones
Creators: name: Kut, Diana Zh.
name: Kut, Mykola M.
name: Ostapchuk, Eugeniy M.
name: Onysko, Mikhajlo Yu.
name: Onys’ko, Petro P.
name: Lendel, Vasil G.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Electrophilic intramolecular heterocyclizations of 3-alkenyl-2-thioxoquinazolin-4-ones, induced by halogens, NBS, sulfuryl chloride, protic acids, selenium, or tellurium halides, proceed with high regioselectivity. This process leads to the formation of 2-functionalized dihydrothiazolo[2,3-b]quinazolines, showcasing the versatility and reliability of this synthetic route across various electrophilic reagents.
Design, synthesis and antioxidant studies of thiopyrimidine-based Passerini reaction: sulfur linked derivatives
Creators: name: Rupapara, Mahesh
name: Kamdar, Jignesh
name: Kuchhadiya, Jyoti
name: Chauhan, Mehul
name: Alarifi, Abdullah
name: Kapadiya, Khushal
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Researchers have shown that sulfur-based heterocyclic frameworks form the backbone of a wide variety of synthetic analogues with a wide variety of medicinal actions. In this study, Passerini 3-component condensation reaction (P-3-CCR) approach has been used for the design strategy for imparting sulfur-based starting material, synthesis and antioxidant potential of sulfur containing pyrimidine (α-acyloxy amide) derivatives. The thorough assessment of antioxidant activities with a reference drug allows a proficient assessment of the structure–activity relationships (SARs) of the diversely synthesized molecules of the series. Compounds 4f with 3,4-(OMe)2 [17.35 ± 0.14 µM] and 4h with 4-NO2 [19.21 ± 0.14 µM] functionalities were identified as lead scaffolds with minimum IC50 values. A molecular docking investigation was also performed to compute the binding free energy of 4h and 4f to 1F9G. The results revealed a strong binding affinity (-7.1 kcal/mol) of both compounds as compared to that of ascorbic acid (-6.2 kcal/mol). A design strategy though molecular docking followed by MCRs approach to identify new α-acyloxy amides provided an outstanding approximation and shedded light on the sites of binding for their better use in medicinal field.
COMPARATIVE PROBIOTIC ACTIVITY AGAINST STREPTOCOCCUS PYOGENES.
Creators: name: Yuldasheva M.K - doctoral student Mamatova Z.B - associate professor Narziev B.D. - professor
Publisher: name: Zenodo
Year: 2024

description: This article presents the results of studying the activity of twoprobiotic drugs of Russian origin Lactobacterin+, Sporobacterin, one probioticcreated by employees of the Samarkand state university of veterinary medicine,livestock and biotechnology - Innoprovet2 and the antibiotic ciprofloxacin, whichdemonstrated high antimicrobial activity against the pyogenic microbe Str.pyogenesisolated from abscesses of cattle. A comparative study showed that all probioticsshowed high antimicrobial activity equal to antibiotic activity.
BETONNI BUZMASDAN MUSTAHKAMLIGINI ANIQLASH
Creators: name: Erboyev, Sh.
name: Mahramov, M.A.
name: Abdumannopov, M.A.
Publisher: name: Zenodo
Year: 2024

description: Hozirgi kunda turli soxalarda beton va temir beton buyumlaridan foydalanilmoqda shu betonlarni xavfsiz va mustahkam ekanligini aniqlash uchun quyidagi usullar orqali uning mustahkamligini aniqlash usullarini oʻrganamiz.
Template Data Sharing Agreement
Creators: name: McNamara, Edel
name: Pruner Marques, Larissa
name: Jorge, Vanessa de Arruda
name: Islam, Md.Saimul
name: Uppal, Aashna
name: Wozencraft, Anne
name: Postlethwaite, Neil
name: Retford, Matthew
name: Boylan, Sally
name: Kiosia, Agklinta
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Data protection
subject: Data processing
subject: Data science
subject: Health Data Science

description: This template data sharing agreement aims to enable data sharing between partner organisations seeking to collaborate on global health research studies. The template has been developed with the objective of being concise, equitable and easy to use, and to enable collaborating institutions to customise where needed so additional terms can be added to meet specific requirements.

How to use:

This agreement can be used when one institution would like to share data with researchers from another for research purposes

Throughout the document, we have highlighted areas which will need to be amended for specific research projects or purposes

This document is offered on an as-is basis without any representation or endorsement made and without liability or warranty of any kind.  When using and customising this document, we recommend you work with your organisation’s legal and/or contracts team.

If you have any feedback on this document, please email: hdrglobal@hdruk.ac.uk
Multicomponent one pot synthesis of substituted pyridines with a highly active and recyclable hydrotalcite-lanthanum nanocatalyst
Creators: name: Kamali, Farinaz
name: Alibeik, Mohammad Abdollahi
name: Hamidi, Zeinab
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Herein, the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives has been studied due to wide applications of highly substituted pyridines. At first, Hydrotalcite (HT) with various loading amounts of lanthanum (HT-La) was synthesized. Then, their catalytic activities were investigated for the condensation reaction of benzaldehyde, malononitrile, and thiophenol under reflux condition as a model reaction. The prepared HT nanocatalyst with 10 mol% of La showed the best performance in this multicomponent reaction. In addition, the reusability of the nanocatalyst was studied and the results showed, that the prepared nanocatalyst could be reused several times with an only moderate decrease in activity. Subsequently, HT-La (10 mol%) efficiently catalyzed the one-pot condensation reaction for the synthesis of highly substituted pyridines under reflux conditions. The products were produced with excellent yields, short reaction times, and easy recyclability of the nanocatalyst.
Multigram synthesis of 2-vinylpyridine using bio-renewable 2-methyl tetrahydrofuran solvent
Creators: name: Chandrasekhar, Manchikanti M.
name: Ramakrishna, D. S.
name: Behera, Priyanka
name: Chitturi, Bhujanga Rao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The present work reports the synthesis of 2-vinylpyridine in multigram synthetic approach as it has tremendous application in pharmaceutical science as well as in material science and industries. This present method emphasizes the usage of commercially available inexpensive raw materials and bio renewable solvents. Nontoxic TCCA was used as green chlorinating reagent and its corresponding bi-product obtained in the course of the reaction is biodegradable in nature. This entire three step procedure does not require any chromatographic techniques and the product is obtained in 95% yield with > 98% purity.
ФАСЦИОЛЁЗ ВА ПАРАМФИСТОМАТОЗНИ УРГАНИЛИШИ (адабиётлар таҳлили)
Creators: name: Даминов А.С. – вет. ф.д. профессор Кулмирзаева М.И. – магистр
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада республикамиз яқин ва узоқ хорижийолимларнинг асосий трематодозлар фасциолёз ва парамфистоматознингэпизоотологик ҳолати, мавсумий динамикаси, тур таркиби, ҳайвонларнингёшга боґлиқ ҳолда инвазия экстенсивлиги ва интенсивлиги ҳақидаги адабиётмаьлумотлари таҳлили келтирилган
Investigation of pure and Sn-doped Ca(OH)2 nanoparticles for optical and biomedical applications
Creators: name: Balasubramanian, Karthikeyan
name: Murugesan, Sureshkumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: The present study explores the synthesis and characterization of pure and Sn-doped Ca(OH)2 nanoparticles, highlighting their potential for optical and biomedical applications. The incorporation of Sn into the Ca(OH)2 matrix is investigated for the first time, providing insights into its impact on the structural, optical, and biological properties of the nanoparticles. A straightforward precipitation method was employed to synthesize pure and Sn-doped calcium hydroxide nanoparticles. The synthesized nanoparticles were characterized by using X-ray diffraction (XRD) pattern, ultraviolet–visible–near infrared (UV-Vis-NIR) spectra, Fourier Scanning Electron Microscope (FESEM) micrographs, and agar well diffusion method for antibacterial study. X-ray diffraction examinations confirmed the polycrystalline nature of the Ca(OH)2 nanoparticles and revealed the structure to be hexagonal. The average crystallite size of the pure and Sn-doped Ca(OH)2 nanoparticles are 49 nm and 66 nm, respectively. The FESEM images of the sample revealed the formation of pure Ca(OH)2 nanoparticles in the form of nanoflakes and the change in the morphology while doping Sn with Ca(OH)2. The prepared samples were assessed using UV-Vis-NIR spectra, showing the UV absorption band at approximately 247 and 263 nm for the samples of pure and Sn-doped Ca(OH)2 nanoparticles, respectively. The calculated direct and indirect allowed band gap energies were found to be 4.04 and 3.92 eV for pure Ca(OH)2, and 3.37 and 2.94 eV in the case of Sn-doped Ca(OH)2. The antibacterial effectiveness of Ca(OH)2 nanoparticles was assessed using the well diffusion method, and it was observed that both the samples of pure and Sn doped Ca(OH)2 nanoparticles exhibited significant antibacterial properties against gram-negative bacterial strains. An elevation in Minimum Inhibitory Concentration (MIC) values for Sn-doped Ca(OH)2 nanoparticles compared to pure Ca(OH)2 nanoparticles was observed when examining their impact on Gram-negative bacteria (Klebsiella pneumoniae), which suggested a requirement for a higher concentration due to the nature of surface charges present in order to inhibit the growth of microorganisms.
МЕТОДИКА ОБУЧЕНИЯ  ИСПОЛЬЗОВАНИЮ  АУТЕНТИФИКАЦИИ НА ОСНОВЕ ПАРОЛЯ В ИНФОРМАЦИОННОЙ БЕЗОПАСНОСТИ
Creators: name: Вохидов, Дилшод
name: Ниятқобилова, Мохинур
name: Нодиршоева, Зулфия
name: Махсудова, Баҳор
Publisher: name: Zenodo
Year: 2024

description: Основная цель – изучение теоретических и практических аспектов компьютерной безопасности, знание методов парольной защиты, а также формирование и развитие навыков и умений использовать их на практике.
O reconhecimento do estresse físico e psíquico do cuidador em Cuidado Paliativo
Creators: name: Alves de Oliveira, João Batista
Publisher: name: Zenodo
Year: 2024
Subjects: Cuidado Paliativo
Cuidador
Burnout

description: No Cuidado Paliativo é essencial reconhecer que não só o paciente, mas seus cuidadores também devem ser o foco do cuidado e saber reconhecer o grande impacto que doenças graves, progressivas e ameaçadoras da vida provocam sobre esse cuidador, especialmente o informal, sendo fundamental a adoção de medidas preventivas que minimizem o efeito físico e psíquico e sendo de extrema importância a avaliação do componente social para se avaliar a melhor forma de intervenção
Amtliches Verzeichnis der Lehrer, Beamten und Studierenden an der Königlich-Bayerischen Ludwig-Maximilians-Universität zu München 1884; 1884
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 1884

description: Textfreie Seiten wurden entfernt.
Clinical effectiveness of nirmatrelvir plus ritonavir for patients with COVID-19 and preexisting psychiatric disorders
Creators: name: Liu, Ting-Hui
name: Wu, Jheng-Yan
name: Huang, Po-Yu
name: Hsu, Wan-Hsuan
name: Chuang, Min-Hsiang
name: Tsai, Ya-Wen
name: Lai, Chih-Cheng
name: Huang, Charles Lung-Cheng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: This study assessed the clinical effectiveness of the combination of nirmatrelvir and ritonavir (NMV-r) in treating nonhospitalized patients with COVID-19 who have preexisting psychiatric disorders. Patients diagnosed with COVID-19 and psychiatric disorders between 1 March 2020, and 1 December 2022, were included using the TriNetX network. The primary outcome was the composite outcome of all-cause emergency department (ED) visits, hospitalization, or death within 30 days. Propensity score matching yielded two cohorts of 20,633 patients each. The composite outcome of all-cause ED visits, hospitalization, or death within 30 days was 3.57% (737 patients) in the NMV-r cohort and 5.69% (1176) in the control cohort, resulting in a reduced risk in the NMV-r cohort (HR: 0.657; 95% confidence interval (CI): 0.599–0.720). The NMV-r cohort exhibited a lower risk of all-cause hospitalization (HR: 0.385; 95% CI: 0.328–0.451) and all-cause death (HR: 0.110; 95% CI: 0.053–0.228) compared with the control group. NMV-r could mitigate the risk of adverse outcomes in nonhospitalized patients with COVID-19 and preexisting psychiatric disorders. However, only a limited number of patients in this population received adequate treatment, thus emphasizing the importance of promoting its appropriate use.
Synthesis, characterization, and antimicrobial activity of some benzimidazolyl, benzoxazolyl, benzothiazolyl-methylsulfanyl-4-aryl-1,4-dihydropyrimidine-5-carbonitrile derivatives
Creators: name: Celiane, Die Rachelle
name: Mélissa, Ambeu-Loko N’ta Christelle
name: Bamba, Fante
name: Marie-Aude, Hiebel
name: Franck, Suzenet
name: Aurélie, Vallin
name: Vincent, Chagnault
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: We synthetized some methylsulfanyl-4-aryl-1,4-dihydropyrimidine-5-carbonitriles derivatives coupled with benzimidazole, benzoxazole, and benzothiazole rings. Some of these compounds exhibit antibacterial activity, particularly against gram-positive bacteria such as Enterococcus faecalis (6e) and Staphylococcus aureus (4f, 6b, 6i, and 8a).
Comparison of dolutegravir+Lamivudine and bictegravir/emtricitabine/tenofovir alafenamide in antiretroviral therapy-naïve patients infected with HIV: preliminary results from clinical practice
Creators: name: Gan, Lin
name: Xie, Xiaoxin
name: Fu, Yanhua
name: Yang, Xiaoyan
name: Ma, Shujing
name: Kong, Linghong
name: Song, Chunli
name: Song, Yebing
name: Ren, Tingting
name: Long, Hai
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The efficacy and safety of dolutegravir+lamivudine (DTG +3TC) and bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) have been demonstrated in clinical trials of treatment-naïve therapy. However, real-life data are lacking. We investigated and compared the virological outcomes and safety of DTG + 3TC with BIC/FTC/TAF in an adult cohort of people living with HIV (PLWH). We performed a retrospective cohort analysis of PLWH who were naïve to antiretroviral therapy and initiated the antiretroviral regimen of DTG + 3TC or BIC/FTC/TAF from January 2020 to March 2022. Treatment effectiveness, defined as the capability of treatment to achieve viral suppression (viral load < 50 copies/mL), was analyzed. Changes in immunology, metabolism, liver and renal function after 48 weeks of treatment were evaluated. At 48 weeks, both groups showed high viral suppression, with 82.4% (108/131) and 89% (129/145) of the patients in the BIC/FTC/TAF and DTG + 3TC groups, respectively, having viral suppression (OR = 0.58, 95% CI: 0.29–1.15, P = 0.3). No differences existed in immunology, metabolism, liver and renal function; however, BIC/FTC/TAF led to greater weight gain. Both optimization strategies showed high tolerability in antiretroviral therapy-naïve patients, with no differences in virological efficacy; however, BIC/FTC/TAF may be related to the risk of weight gain risk. Further research is required to evaluate this problem.
MPEC 2024-J91 : 2024 JD2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 JD2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Chloromonas rubrosalmonea sp. nov. (Chlorophyta) causes blooms of salmon-red snow due to high astaxanthin and low chlorophyll content
Creators: name: Procházková, Lenka
name: Remias, Daniel
name: Suzuki, Hirono
name: Kociánová, Milena
name: Nedbalová, Linda
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Melting snowfields support microbial communities, including blooms of phototrophic psychrophiles. “Watermelon snow” and its flagship species Sanguina nivaloides are mostly found at exposed, alpine or polar sites. Here, we investigated an alga that is morphologically similar but likely less common, thriving in exposed or semi-exposed snowpacks at lower altitudes frequently close to the tree line, and causing characteristic, intensely salmon-red snow surface spots in Central European and Norwegian mountains. Our aim was to illustrate the taxonomic heterogeneity of red snow by performing a cellular and molecular characterization of this species. The phylogenetic analysis placed the alga into the genus Chloromonas, clade “group C”. Single-cell Sanger sequencing enabled us to link the cell morphotype to its genotype. In addition to light microscopy of the snow samples, applying 18S rRNA gene and ITS2 metabarcoding confirmed that this alga dominated the bloom communities. The cysts had multi-layered smooth cell walls, and had a broadly oval to fully spherical shape, in striking contrast to most other Chloromonas species found on snow surfaces. Another remarkable feature was a pronounced astaxanthin accumulation in relation to a low proportion of chlorophylls, occasionally accompanied by a significant reduction of thylakoid membranes. This likely caused the photosynthetic dormancy of mature cysts found in some samples. Based on these data, we describe the snow alga as Chloromonas rubrosalmonea, sp. nov.
Interactions between mangrove soil, water, and microbes in degraded, natural, and restored tropical coastline ecosystems
Creators: name: Dookie, Sabrina
name: Jaikishun, Sirpaul
name: Ansari, Abdullah Adil
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology

description: The interactions among soil, water, and microbes are unique and fundamental in mangrove forests. We examined and compared the physicochemical parameters of soil (pH, Organic Carbon (OC), Electrical Conductivity (EC), N, P, K, Mg, Ca, S, Fe, Zn, Cu, and Mn) and water (pH, temperature, Total Dissolved Solids (TDS), EC) as well as microbial diversity and abundance in nine natural, degraded, and restored mangrove ecosystems along Guyana’s coastline. Sampling was done using a randomized block design for one year in two seasons. Significant differences, correlations (p < 0.05, R > 0.75) and regressions in water and soil parameters were documented for the natural ecosystems and restored ecosystems in both seasons. Additionally, microbial abundance was greater in the restored ecosystems, while seasonal variations in diversity were seen in the degraded and restored ecosystems. Our study lends some credence to the idea that ecosystem type and seasonality can influence soil, water, and microbial interactions, which can ultimately affect mangrove biodiversity. Mangroves fulfill significant functions in coastal protection by mitigating erosion, enhancing sediment accumulation, and actively combating the challenge of rising sea levels.Mangroves significantly enhance productivity within several biogeochemical cycles, hence fostering sustainable biodiversity and establishing advantageous linkages with adjacent forest ecosystems.The exceptional levels of resilience and adaptation exhibited by mangrove forests enable them to consistently deliver ecosystem goods and services, while concurrently serving as effective mitigating agents in the ongoing climate change crisis.Anthropogenic activities pose a significant threat to the viability and effectiveness of mangroves, resulting in the decline and deterioration of these ecosystems. Mangroves fulfill significant functions in coastal protection by mitigating erosion, enhancing sediment accumulation, and actively combating the challenge of rising sea levels. Mangroves significantly enhance productivity within several biogeochemical cycles, hence fostering sustainable biodiversity and establishing advantageous linkages with adjacent forest ecosystems. The exceptional levels of resilience and adaptation exhibited by mangrove forests enable them to consistently deliver ecosystem goods and services, while concurrently serving as effective mitigating agents in the ongoing climate change crisis. Anthropogenic activities pose a significant threat to the viability and effectiveness of mangroves, resulting in the decline and deterioration of these ecosystems.
АСАЛАРИ КАСАЛЛИКЛАРИГА ҚАРШИ АНТИБИОТИКЛАР САМАРАДОРЛИГИ
Creators: name: Юнусов Х.Б. – биология фанлари доктори, профессор Ибрагимов Ф.Б. – ветеринария фанлари номзоди, доцент, Дускулов В.М. – ветеринария фанлари номзоди, доцент в.б., Суюнов Р.У. - ассистент Бердиева Н.М. - талаба Рустамова Ш.А.
Publisher: name: Zenodo
Year: 2024

description: В статье переведена сведения о болезни встречающийсясемействе пчел, а также о порядке подачи сахарного сиропа с препаратомстрептоцид для лечения американском гнилья, и варроатоза и егоэффективности против этих заболевания