cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SIENNA D2.5: Public views on genetics, genomics and gene editing in 11 EU and non-EU countries
Creators: name: Hanson, Tim
Publisher: name: Zenodo
Year: 2020
Subjects: human genomics
whole genome sequencing
genetic testing
gene editing
exploratory public survey
ELSI
public opinion

description: Based on a telephone survey of 1,000 people in each of 11 countries (EU: France, Germany, Greece, the Netherlands, Poland, Spain, Sweden; non-EU: Brazil, South Africa, South Korea, USA), this report provides a snapshot of awareness, understanding and opinions on human genetics and genomics in 2019. Most respondents, in all countries, had at least heard of both genetics or DNA and gene editing in humans. However, there was variation between countries in the proportion of respondents who said they had seen or heard a lot or a fair amount about these areas. The majority of respondents in all countries felt that it was important for people tounderstand more about genetics or DNA. Opinions regarding experimenting on human embryos differed based onthe purpose of the research. Generally, it was thought of as unacceptable to carry out research on human embryos for ‘any purpose’ or to ‘increase human intelligence’. However, the majority of respondents thought thiswould be acceptable if the purpose of this research was to understand ‘how to treat or cure severe health conditions. Respondents were split on whether researchers understood the health risks and benefits of changing an unborn baby’s DNA, as well as on who should be responsible for decision making about how genetic technologies are used. Opinions varied between countries on whether all babies should have their all DNAanalysed at birth. In some countries, a majority agreed with this statement and in other countries, a majority disagreed with the statement. In all countries, a majority of respondents agreed that the termination of pregnancies as a result of genetic tests would lead to disabled people becoming less accepted in society, and that parents would come to feel pressured to have genetic tests on their unborn babies if the practice becomes more common.
Cognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907
Creators: name: Pitcher, Brandelyn
name: Cohen, Harvey Jay
name: Keating, Nancy L.
name: Mandelblatt, Jeanne
name: Muss, Hyman B.
name: Hurria, Arti
name: Winer, Eric P.
name: Kornblith, Alice B.
name: Hudis, Clifford A.
name: Freedman, Rachel A.
name: Kimmick, Gretchen G.
name: Ballman, Karla V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Cognitive changes in older women receiving chemotherapy are poorly understood. We examined self-reported cognitive function for older women who received adjuvant chemotherapy on Cancer and Leukemia Group B (CALGB) 49907. CALGB 49907 randomized 633 women aged ≥65 with stage I–III breast cancer to standard adjuvant chemotherapy (cyclophosphamide–methotrexate–5-fluoro-uracil or doxorubicin–cyclophosphamide) versus capecitabine. We examined self-reported cognitive function in 297 women (CALGB 361002) who enrolled on the quality of life substudy and had no gross impairment on cognitive screening. Women were evaluated using an 18-item instrument at six time points (baseline through 24 months). At each time point for each patient, we calculated a cognitive function score (CFS) defined as the mean response of items 1–18 and defined impairment as a score >1.5 standard deviations above the overall average baseline score. Differences in scores by patient characteristics were evaluated using a Kruskal–Wallis test. A linear mixed-effects model was used to assess CFSs by treatment over time. Among 297 women, the median age was 71.5 (range 65–85) and 73 % had performance status of 0. Baseline depression and fatigue were reported in 6 and 14 % of patients, respectively. The average CFS at baseline was 2.08 (corresponding to “normal ability”), and baseline cognitive function did not differ by treatment regimen (p = 0.350). Over 24 months, women reported minimal changes at each time point and insignificant differences by treatment arm were observed. In a healthy group of older women, chemotherapy was not associated with longitudinal changes in self-reported cognitive function.
title: European regional elite behaviour: A comparative study of political and business elites in the Strathclyde region of Scotland and Nomos Chanion in Crete
Creators: name: Christopoulos, Dimitrios C.
Publisher: name: University of Glasgow
Year: 1996
Subjects: subject: Political science, European studies.

description: In the framework of the European Communities and later the European Union a number of policies were devised for the European regions to facilitate their balanced economic development. An attempt to co-ordinate these policies can be linked to the fact that European regions are increasingly interdependent and European Union policies increasingly more relevant to this interdependence. Socio-economic and regional planning information between the Community regions is vital in this interdependent environment. The importance placed by the academic literature and by the European Commission on regional planners and their actions has to an extent obscured the importance of regional elites in this process. This thesis attempts to redress the balance, and does so by means of a series of interviews with business and political elites on the effects and prospects of further economic integration as well as administrative and political autonomy. I am comparing Western Scotland and the west of Crete focusing on the wider regional political and business elites within these regions. My assumption that the interaction of regional elites with each other can be, at least partly, responsible for competitiveness differentials between regions underlies most of this analysis. I attempt a comparison of elite attitudes within regions and between regions, giving particular attention to the effect aspirations to autonomy may have on elite perspectives. I have been able to discern and identify a relationship between regional elite attitudes on devolution and their perceptions of business prospects in a region. I have also identified a relationship between the attitudinal concordance among a region's elite groups and regional growth prospects. Furthermore, I have identified certain value groups for which attitudinal concordance appears significant to elite co-operation. Ensuing conclusions do not necessarily have predictive value but, by identifying attitudinal patterns among regional elites, can provide an insight into the transforming effect of European integration and modernity on European regional civil societies.
Complete Classification of Four-Dimensional Black Hole and Membrane Solutions in IR-modified Hořava Gravity
Creators: name: Argüelles, Carlos
name: Grandi, Nicolás
name: Park, Mu-In
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Hořava gravity has been proposed as a renormalizable, higher-derivative gravity without ghost problems, by considering different scaling dimensions for space and time. In the non-relativistic higher-derivative generalization of Einstein gravity, the meaning and physical properties of black hole and membrane space-times are quite different from the conventional ones. Here, we study the singularity and horizon structures of such geometries in IR-modified Hořava gravity, where the so-called "detailed balance" condition is softly broken in IR. We classify all the viable static solutions without naked singularities and study its close connection to non-singular cosmology solutions. We find that, in addition to the usual point-like singularity at $r=0$, there exists a "surface-like" curvature singularity at finite $r=r_S$ which is the cutting edge of the real-valued space-time. The degree of divergence of such singularities is milder than those of general relativity, and the Hawking temperature of the horizons diverges when they coincide with the singularities. As a byproduct we find that, in addition to the usual "asymptotic limit," a consistent flow of coupling constants, that we called "GR flow limit," is needed in order to recover general relativity in the IR.
description: Accepted in JHEP, Typos corrected
Diagnostic imaging and biopsy pathways following abnormal screen-film and digital screening mammography
Creators: name: Henderson, Louise
name: Karliner, Leah
name: Buist, Diana S.M.
name: Lee, David
name: Hubbard, Rebecca A.
name: Horblyuk, Ruslan
name: Sweet, Alison
name: Sprague, Brian L.
name: Zhu, Weiwei
name: Onega, Tracy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The transition from screen-film to digital mammography may have altered diagnostic evaluation of women following a positive screening examination. This study compared use and timeliness of diagnostic imaging and biopsy for women screened with screen-film or digital mammography.
Leichenpredigt und Personalien des sel. Landesstatthalter und Nationalrath Dr. Johann Ulrich Meier von Trogen, bei dessen den 14. Februar 1868 in Trogen stattgehabten Beerdigung
Creators: name: Bion, Walter
Publisher: name: Druck und Verlag der M. Schläpfer'schen Buchdruckerei
Year: 1868
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Meyer, Johann Ulrich
subject: Trogen (Appenzell Ausserrhoden)
subject: Wald (Appenzell Ausserrhoden)
subject: Wien

description: Auf vielseitiges Verlangen in Druck herausgegeben
Differential methylation relative to breast cancer subtype and matched normal tissue reveals distinct patterns
Creators: name: Fan, Cheng
name: Bardowell, Sabrina A.
name: Swift-Scanlan, Theresa
name: Crandell, Jamie
name: Parker, Joel
name: Perou, Charles M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Due to the heterogeneous nature of breast cancer and the widespread use of single-gene studies, there is limited knowledge of multi-gene, locus-specific DNA methylation patterns in relation to molecular subtype and clinical features. We, therefore, quantified DNA methylation of 70 candidate gene loci in 140 breast tumors and matched normal tissues and determined associations with gene expression and tumor subtype. Using Sequenom’s EpiTYPER platform, approximately 1,200CpGs were interrogated and revealed six DNA methylation patterns in breast tumors relative to matched normal tissue. Differential methylation of several gene loci was observed within all molecular subtypes, while other patterns were subtype-dependent. Methylation of numerous gene loci was inversely correlated with gene expression, and in some cases, this correlation was only observed within specific breast tumor subtypes. Our findings were validated on a larger set of tumors and matched adjacent normal tissue from The Cancer Genome Atlas dataset, which utilized methylation data derived from both Illumina Infinium 27 and 450k arrays. These findings highlight the need to control for subtype when interpreting DNA methylation results, and the importance of interrogating multiple CpGs across varied gene regions.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-013-2738-0) contains supplementary material, which is available to authorized users.
HANK_case_study.pdf
Creators: name: Prieto, Guillermo Asín
name: Sarasua, Ane Intxaurburu
name: Seco, Maite Fernández
name: Isoird, Carlos Fernández
Publisher: name: figshare
Year: 2020
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: This is an extended abstract of a paper we are preparing with a wider sample of patients. We present the preliminary findings towards the optimization of the robotic exoskeleton used in our study.
Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features
Creators: name: Harrell, J. Chuck
name: Spillman, Monique A.
name: Horwitz, Kathryn B.
name: Post, Miriam D.
name: Jacobsen, Britta M.
name: Jambal, Purevsuren
name: Badtke, Melanie M.
name: Borges, Virginia F.
name: Sollender, Grace E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Mucinous breast cancer (MBC) is mainly a disease of postmenopausal women. Pure MBC is rare and augurs a good prognosis. In contrast, MBC mixed with other histological subtypes of invasive disease loses the more favorable prognosis. Because of the relative rarity of pure MBC, little is known about its cell and tumor biology and relationship to invasive disease of other subtypes. We have now developed a human breast cancer cell line called BCK4, in which we can control the behavior of MBC. BCK4 cells were derived from a patient whose poorly differentiated primary tumor was treated with chemotherapy, radiation and tamoxifen. Malignant cells from a recurrent pleural effusion were xenografted in mammary glands of a nude mouse. Cells from the solid tumor xenograft were propagated in culture to generate the BCK4 cell line. Multiple marker and chromosome analyses demonstrate that BCK4 cells are human, near diploid and luminal, expressing functional estrogen, androgen, and progesterone receptors. When xenografted back into immunocompromised cycling mice, BCK4 cells grow into small pure MBC. However, if mice are supplemented with continuous estradiol, tumors switch to invasive lobular carcinoma (ILC) with mucinous features (mixed MBC), and growth is markedly accelerated. Tamoxifen prevents the expansion of this more invasive component. The unexpected ability of estrogens to convert pure MBC into mixed MBC with ILC may explain the rarity of the pure disease in premenopausal women. These studies show that MBC can be derived from lobular precursors and that BCK4 cells are new, unique models to study the phenotypic plasticity, hormonal regulation, optimal therapeutic interventions, and metastatic patterns of MBC.
title: Value of MDTC imaging in atypical spinal tuberculosis
Creators: name: BIgnardi, Elio
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: CT
subject: Diagnostic procedure
subject: Infection

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The aim of this retrospective study was to evaluate MDTC imaging in patients with atipical spinal tubercolosis . Any tuberculous vertebral lesion, with does not have classical features of Pott's disease is referred to as atypical spinal TB. Atypical...
Comparison of the lateral retention forces on sessile and pendant water drops on a solid surface
Creators: name: de la Madrid, Rafael
name: Whitehead, Taylor
name: Irwin, George
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We present a simple experiment that demonstrates how a water drop hanging from a Plexiglas surface (pendant drop) experiences a lateral retention force that is comparable to, and in some cases larger than, the lateral retention force on a drop resting on top of the surface (sessile drop). The experiment also affords a simple demonstration of the Coriolis effect in two dimensions.
title: Value of MDCT in musculoskeletal manifestations in HIV-infected patients.
Creators: name: BIgnardi, Elio
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal system
subject: CT
subject: Diagnostic procedure
subject: Infection

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The aim of this retrospective study was to evaluate MDCT imaging in muscoloskeletal manifestations in HIV-infected patients. Muscoloskeletal manifestations in HIV-infected patients include: Rheumatologic syndrome as a consequence of HIV infection...
title: The anterolateral ligament in young patients under eighteen with and without knee injury: A visibility study with magnetic resonance imaging
Creators: name: Kranewitter, Christof
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Trauma
subject: Decision analysis
subject: MR
subject: Musculoskeletal joint
subject: Extremities

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: To assess the visibility of the anterolateral ligament (ALL) in patients under 18 years with and without knee injury. Further to evaluate and characterize possible injuries of the...
Fixed-dose capecitabine is feasible: results from a pharmacokinetic and pharmacogenetic study in metastatic breast cancer
Creators: name: Fetting, John H.
name: Garrett-Mayer, Elizabeth
name: Rudek, Michelle A.
name: Armstrong, Deborah K.
name: Wright, Laurie A.
name: Hoskins, Janelle M.
name: Stearns, Vered
name: Davidson, Nancy E.
name: Wolff, Antonio C.
name: Connolly, Roisin M.
name: Zhao, Ming
name: McLeod, Howard L.
name: Watkins Jr., Stanley P.
name: Jeter, Stacie C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The pro-drug capecitabine is approved for treatment of anthracycline- and paclitaxel-resistant metastatic breast cancer. However, toxicity and large interpatient pharmacokinetic variability occur despite body surface area (BSA)-dosing. We hypothesized that a fixed-dose schedule would simplify dosing and provide an effective and safe alternative to BSA-based dosing.
WB -Original date
Creators: name: bu, xianzhong
name: Bu, Baoxian
name: Qin, Baijun
name: Zhong, Ni
name: Mai, Wei
name: Yu, Weibo
name: Xu, Wei
name: Zhong, Yuanming
name: Li, Zhifei
Publisher: name: figshare
Year: 2023
Subjects: Orthopaedics
Pathology (excl. oral pathology)

description: Compared with those in the healthy controls (HC) group, the levels of PPP2R1A, MYL9 and ALOX12 expressions were downregulated in the serum in the DCCS group (P < 0.05) .
Impact of breast cancer on anti-mullerian hormone levels in young women
Creators: name: Demichele, A.
name: Su, H. I.
name: Steiner, A. Z.
name: Natarajan, L.
name: Flatt, S. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Young women with breast cancer face treatments that impair ovarian function, but it is not known if malignancy itself impacts ovarian reserve. As more breast cancer patients consider future fertility, it is important to determine if ovarian reserve is impacted by cancer, prior to any therapeutic intervention.
title: Τεχνικές παρεμβάσεις για τη μείωση της ενεργειακής κατανάλωσης κτιρίου δημοσίου τομέα - Η περίπτωση του Δημαρχείου Καλαμάτας
Creators: name: Ηλιοπουλου Σταυρουλα
Publisher: name: Technical University of Crete
Year: 2020

description: Η παρούσα διπλωματική εργασία έχει ως σκοπό την ενεργειακή επιθεώρηση ενός
ήδη υφιστάμενου κτιρίου τριτογενούς τομέα, του Δημαρχείου Καλαμάτας, καθώς
και την πρόταση τεσσάρων επενδυτικών σεναρίων που αποσκοπούν στην ελάττωση των ενεργειακών του αναγκών.
Στο πρώτο κεφάλαιο γίνεται μία σύντομη εισαγωγή στον Κανονισμό Ενεργειακής
Απόδοσης Κτιρίων, που αποτελεί την ισχύουσα νομοθεσία η οποία αφορά τις
ενεργειακές καταναλώσεις τόσο των ήδη υφιστάμενων κτιρίων, όσο και των νέων
προς κατασκευή κτιρίων.
Στο δεύτερο κεφάλαιο γίνεται μία σύντομη περιγραφή και ιστορική αναδρομή του
κτιρίου υπό μελέτη, καθώς και μία εισαγωγή στα δύο βασικά μέρη του
προγράμματος 4Μ, το οποίο θα χρησιμοποιηθεί για να γίνει η ενεργειακή
επιθεώρηση.
Το τρίτο κεφάλαιο αναφέρεται στο σχεδιαστικό κομμάτι του 4Μ, το GCAD, στο οποίο ο ενεργειακός επιθεωρητής σχεδιάζει το κτίριο και ορίζει τόσο τα βασικά δομικά του στοιχεία, όσο και τυχόν εξωτερικά στοιχεία τα οποία μπορούν με κάποιο τρόπο να επηρεάσουν την ενεργειακή του κατανάλωση.
Στο τέταρτο κεφάλαιο, γίνεται ανάλυση του υπολογιστικού τμήματος του 4Μ, το
ΕΝΚΑ (Ενεργειακά – Κτίριο Αναφοράς), όπου αντλούνται όλα τα εισαχθέντα στοιχεία του σχεδιαστικού και ορίζονται τα συστήματα του κτιρίου υπό μελέτη, με τελικό αποτέλεσμα την εξαγωγή της ενεργειακής του κλάσης.
Το πέμπτο κεφάλαιο αποτελεί την παράθεση τεσσάρων σεναρίων, τα οποία
αποσκοπούν στη μείωση των ενεργειακών καταναλώσεων του κτιρίου υπό μελέτη,
συνοδευόμενα από την εκτίμηση του κόστους και της αποπληρωμής του εκάστοτε
σεναρίου, σύμφωνα με το πρόγραμμα «Εξοικονομώ κατ’ οίκον».
Στο έκτο κεφάλαιο εξάγονται συμπεράσματα σχετικά με τα σενάρια βελτίωσης των
ενεργειακών καταναλώσεων και βγαίνει η καινούρια ενεργειακή κλάση του κτιρίου
υπό μελέτη, μετά την εφαρμογή των σεναρίων.
description: The environmental crisis has made critical the need for greener housing
solutions. In Greece, the construction department has yet to provide
environmentally friendly houses and is far behind compared to other countries
that have made serious advancements in low-cost energy living. Since
construction is scarce in Greece because of the economic crisis that prevails in
the last 10 years, the trend now is to renovate existing buildings, thus promoting
investments in renewable energy and reducing their environmental footprint. The
European Union, in order to promote greener housing, funds these kinds of
renovations up to 70%. In this case study, we get a public building, a city hall,
under the scope of its energy requirements. According to the Energy Performance
of Buildings Directive, we conduct the energy certificate of the building and
provide guidelines that will reduce its energy footprint, alongside with cost
evaluations and investment depreciations.
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion
Creators: name: Bockhorn, Jessica
name: Olopade, Olufunmilayo I.
name: Yee, Kathy
name: Greene, Geoffrey L.
name: Huang, Simo
name: Liu, Huiping
name: Nwachukwu, Chika
name: Chang, Ya Fang
name: Perou, Charles M.
name: Dalton, Rachel
name: Huo, Dezheng
name: Prat, Aleix
name: Clarke, Michael F.
name: Swanson, Kaitlin E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop more effective treatments. Here we show that human breast tumor biomarker miR-30c regulates invasion by targeting the cytoskeleton network genes encoding Twinfilin 1 (TWF1) and Vimentin (VIM). Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition (EMT). Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition to a more invasive mesenchymal phenotype. To further characterize the role of the TWF1 pathway in breast cancer, we found that IL-11 is an important target of TWF1 that regulates breast cancer cell invasion and STAT3 phosphorylation. The miR-30c-VIM/TWF1 signaling cascade is also associated with clinical outcome in breast cancer patients.
title: Multi-modal imaging of elbow trauma injuries and its sequelae in adult patients
Creators: name: Cristiano, Lara
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Trauma
subject: Conventional radiography
subject: CT
subject: MR
subject: Complications
subject: Cost-effectiveness
subject: Trauma
subject: Acute

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The aim of our study was to evaluate the role of cross-sectional imaging medalities inorder to study elbow trauma in adults patients and its complications before...
Gravitons e Gravidade Emergente na Teoria Menezes: Excitações Quânticas na Rede de Qubits
Creators: name: Menezes, Jorge
Publisher: name: Zenodo
Year: 2024
Subjects: gravitons
gravidade emergente
Teoria Menezes
excitações quanticas
Qubits

description: Gravitons e Gravidade Emergente na Teoria Menezes: Excitações Quânticas na Rede de Qubits

Este artigo explora profundamente a relação entre a gravidade emergente, conforme proposta pela Teoria Menezes, e os gravitons, tradicionalmente descritos como mediadores da força gravitacional na teoria quântica de campos. Reformulamos os gravitons como excitações emergentes de uma rede quântica de qubits em estados de superposição e entrelaçamento, propondo uma abordagem alternativa à gravitação. Este trabalho inclui modelos matemáticos detalhados, uma comparação com outras teorias quânticas da gravidade, e uma série de previsões experimentais e observacionais que podem validar essa teoria inovadora. Discutimos também as limitações tecnológicas dos experimentos propostos e o impacto dessa teoria na cosmologia e na física de buracos negros.

A gravidade tem sido um dos maiores desafios na unificação das forças fundamentais da natureza. As forças eletromagnética, fraca e forte são descritas por teorias quânticas de campos, mas a gravidade, conforme descrita pela Relatividade Geral, resiste à quantização. A introdução dos gravitons, partículas hipotéticas que mediam a gravidade, é uma das tentativas de integrar a gravidade ao arcabouço da física quântica.

A Teoria Menezes oferece uma abordagem diferente, sugerindo que o espaço-tempo emerge de uma rede fundamental de qubits em estados de superposição e entrelaçamento. A gravidade, então, é uma propriedade emergente dessas interações quânticas, e os gravitons são uma excitação da rede de qubits. Este artigo explora essa nova abordagem, revisa a literatura relevante, detalha os modelos matemáticos envolvidos e propõe experimentos e simulações numéricas para validar essa teoria.
title: Paediatric Cervical Spine injuries: Incidence, Mechanism and injury pattern at a large Level 1 trauma centre
Creators: name: Davies, Joseph
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Trauma
subject: Paediatric
subject: CT
subject: MR
subject: Conventional radiography
subject: Diagnostic procedure
subject: Trauma

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Cervical spine injury (CSI) in children under 10 years of age is rare and there remains debate around the most common traumatic mechanisms and patterns of injury [ 1 ] . Below the age of 10 years, the paediatric cervical spine (c-spine) differs...
Generalized non-minimal couplings in Randall-Sundrum scenarios
Creators: name: Alencar, G.
name: Jardim, I. C.
name: Landim, R. R.
name: Muniz, C. R.
name: Filho, R. N. Costa
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The Geometrical Localization mechanism in Randall-sundrum (RS) scenarios is extended by considering the coupling between a quadratic mass term and geometrical tensors. Since the quadratic term is symmetric, tensors with two symmetric indices have to be taken into account. These are the Ricci and the Einstein tensors. For the Ricci tensor it is shown that a localized zero mode exists while that is not possible for the Einstein tensor. It is already known that the Ricci scalar generates a localized solution but the metrics do not. Therefore, it can be conclude that divergenceless tensors do not localize the zero mode of gauge fields. The result is valid for any warp factor recovering the RS metrics at the boundaries, and therefore is valid for RS I and II models. We also compute resonances for all couplings. These are calculated using the transfer matrix method. The cases studied consider the standard RS with delta-like branes, and branes generated by kinks and domain-wall as well. The parameters are changed to control the thickness of the smooth brane. We find that, for all cases considered, geometrical coupling does not generate resonances. This enforces similar results for the coupling with the Ricci scalar and points to the existence of some unidentified fundamental structure of these couplings.
description: Typos corrected, 25 pages
Barjols, place de la Rouguière, jeu de l'écharpe exécuté par les gardians
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer
Creators: name: Perou, Charles M.
name: Milner, J. Justin
name: Darr, David B.
name: Freemerman, Alex J.
name: Makowski, Liza
name: Galanko, Joseph A.
name: McNaughton, Kirk K.
name: Johnson, Amy R.
name: Sundaram, Sneha
name: Troester, Melissa A.
name: Bendt, Katharine M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Obesity is associated with basal-like breast cancer (BBC), an aggressive breast cancer subtype. The objective of this study was to determine whether obesity promotes BBC onset in adulthood and to evaluate the role of stromal-epithelial interactions in obesity-associated tumorigenesis. We hypothesized that hepatocyte growth factor (HGF) plays a promoting role in BBC, which express the HGF receptor, c-Met. In C3(1)-Tag mice, a murine model of BBC, we demonstrated that obesity leads to a significant increase in HGF secretion and an associated decrease in tumor latency. By immunohistochemical analysis, normal mammary gland exhibited obesity-induced HGF, c-Met and phospho-c-Met, indicating that activation of the cascade was obesity-driven. HGF secretion was also increased from primary mammary fibroblasts isolated from normal mammary glands and tumors of obese mice compared to lean. These results demonstrate that obesity-induced elevation of HGF expression is a stable phenotype, maintained after several passages, and after removal of dietary stimulation. Conditioned media from primary tumor fibroblasts from obese mice drove tumor cell proliferation. In co-culture, neutralization of secreted HGF blunted tumor cell migration, further linking obesity-mediated HGF-dependent effects to in vitro measures of tumor aggressiveness. In sum, these results demonstrate that HGF/c-Met plays an important role in obesity-associated carcinogenesis. Understanding the effects of obesity on risk and progression is important given that epidemiologic studies imply a portion of BBC could be eliminated by reducing obesity.
Topological surface states and Fermi arcs of the noncentrosymmetric Weyl semimetals TaAs, TaP, NbAs, and NbP
Creators: name: Sun, Yan
name: Wu, Shu-Chun
name: Yan, Binghai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Very recently the topological Weyl semimetal (WSM) state was predicted in the noncentrosymmetric compounds TaAs, TaP, NbAs, and NbP and soon led to photoemission and transport experiments to verify the presumed topological properties such as Fermi arcs (unclosed Fermi surfaces) and the chiral anomaly. In this work, we have performed fully \textit{ab initio} calculations of the surface band structures of these four WSM materials and revealed the Fermi arcs with spin-momentum-locked spin texture. On the (001) polar surface, the shape of the Fermi surface depends sensitively on the surface terminations (cations or anions), although they exhibit the same topology with arcs. The anion (P or As) terminated surfaces are found to fit recent photoemission measurements well. Such surface potential dependence indicates that the shape of the Fermi surface can be manipulated by depositing guest species (such as K atoms), as we demonstrate. On the polar surface of a WSM without inversion symmetry, Rashba-type spin polarization naturally exists in the surface states and leads to strong spin texture. By tracing the spin polarization of the Fermi surface, we can also distinguish Fermi arcs from trivial Fermi circles. The four compounds NbP, NbAs, TaP, and TaAs present an increasing amplitude of spin-orbit coupling (SOC) in the band structure. By comparing their surface states, we reveal the evolution of topological Fermi arcs from the spin-degenerate Fermi circle to spin-split arcs when the SOC increases from zero to a finite value. Our work will help us understand the complicated surface states of WSMs and allow us to manipulate them, especially for future spin-revolved photoemission and transport experiments.
description: This manuscript has been submitted to Physical Review B on 22 Jul. 2015
Finite time collapsing of the Kähler-Ricci flow on threefolds
Creators: name: Tosatti, Valentino
name: Zhang, Yuguang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 53C44, 53C55, 14J45, 32Q15, 58J35, 14E30

description: We show that if on a compact Kahler threefold there is a solution of the Kahler-Ricci flow which encounters a finite time collapsing singularity, then the manifold admits a Fano fibration. Furthermore, if there is finite time extinction then the manifold is Fano and the initial class is a positive multiple of the first Chern class.
description: 15 pages; small changes, final version to appear in Annali SNS
title: Spinal Osseous Lesions in Tuberosclerosis
Creators: name: Örgüç, Ihsan Sebnem
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Dysplasias

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Tuberosclerosis which is a rare neurocutaneous syndrome with autosomal dominant inheritance because of inactivating mutations in the genes tuberous sclerosis 1 or tuberous sclerosis 2 (1). This syndrome is characterized with benign congenital tumors...
Asteroseismic modeling of 16 Cyg A & B using the complete Kepler data set
Creators: name: Metcalfe, Travis S.
name: Creevey, Orlagh L.
name: Davies, Guy R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Asteroseismology of bright stars with well-determined properties from parallax measurements and interferometry can yield precise stellar ages and meaningful constraints on the composition. We substantiate this claim with an updated asteroseismic analysis of the solar-analog binary system 16 Cyg A & B using the complete 30-month data sets from the Kepler space telescope. An analysis with the Asteroseismic Modeling Portal (AMP), using all of the available constraints to model each star independently, yields the same age ($t=7.0 \pm 0.3$ Gyr) and composition ($Z=0.021 \pm 0.002$, $Y_i=0.25 \pm 0.01$) for both stars, as expected for a binary system. We quantify the accuracy of the derived stellar properties by conducting a similar analysis of a Kepler-like data set for the Sun, and we investigate how the reliability of asteroseismic inference changes when fewer observational constraints are available or when different fitting methods are employed. We find that our estimates of the initial helium mass fraction are probably biased low by 0.02-0.03 from neglecting diffusion and settling of heavy elements, and we identify changes to our fitting method as the likely source of small shifts from our initial results in 2012. We conclude that in the best cases reliable stellar properties can be determined from asteroseismic analysis even without independent constraints on the radius and luminosity.
description: 5 emulateapj pages, 1 table, 1 figure. ApJ Letters, accepted
Associação entre a Doença de Crohn e a Artrite Idiopática Juvenil: manifestações clínicas e possibilidades cirúrgicas
Creators: name: PINTO, LUIZA RIBEIRO
name: POHLMANN, BRUNA KELREN  FREITAS
name: NOGUEIRA, PAOLA FALCÃO MOREIRA
name: ALCÂNTARA, ANA CAROLINA DE
name: COSTA, RAYSSA MARA FERRERA
name: DE MELO, DAYANE LOUISE CABRAL
name: AMARANTE, GUILHERME ALVES
name: OLIVEIRA, JORDÂNIA SANTOS
name: CAFÉ, LAIRE SAMELYNE SOUSA COSTA
name: BONFIM, DENISE FERREIRA
Publisher: name: Zenodo
Year: 2024

description: PERIÓDICO MÉDICO NÃO INDEXADO Á NENHUMA BASE DE DADOS
title: The Incidence of Adults with Sternal Fractures in Blunt Thoracic Trauma & Their Associated Injuries: A Single Center Retrospective Study
Creators: name: Anand, Neil
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal system
subject: Musculoskeletal joint
subject: Musculoskeletal bone
subject: CT
subject: Experimental investigations
subject: Trauma

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Sternal fractures are a rare diagnosis in blunt trauma. Although representing only 0.3% of emergency room admissions, they can lead to significant morbidity and mortality when the diagnosis is missed. They are predominantly associated with...
The molecular diversity of Luminal A breast tumors
Creators: name: Jacobsen, Anders S.
name: Ciriello, Giovanni
name: Sinha, Rileen
name: Hoadley, Katherine A.
name: Sander, Chris
name: Perou, Charles M.
name: Reva, Boris
name: Schultz, Nikolaus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Breast cancer is a collection of diseases with distinct molecular traits, prognosis, and therapeutic options. Luminal A breast cancer is the most heterogeneous, both molecularly and clinically. Using genomic data from over 1,000 Luminal Atumors from multiple studies, we analyzed the copy number and mutational landscape of this tumor subtype. This integrated analysis revealed four major subtypes defined by distinct copy-number and mutation profiles. We identified an atypical Luminal A subtype characterized by high genomic instability, TP53 mutations, and increased Aurora kinase signaling; these genomic alterations lead to a worse clinical prognosis. Aberrations of chromosomes 1, 8, and 16, together with PIK3CA, GATA3, AKT1, and MAP3K1 mutations drive the other subtypes. Finally, an unbiased pathway analysis revealed multiple rare, but mutually exclusive, alterations linked to loss of activity of co-repressor complexes N-Cor and SMRT. These rare alterations were the most prevalent in Luminal A tumors and may predict resistance to endocrine therapy. Our work provides for a further molecular stratification of Luminal A breast tumors, with potential direct clinical implications.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-013-2699-3) contains supplementary material, which is available to authorized users.
Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model
Creators: name: Wu, X.
name: Guo, J.
name: Dang, G.
name: Sui, X.
name: Zhang, Q.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: Science Policy

description: Acute toxicity is an important basis for the assessment of hazardous chemicals, but currently there is a huge data gap in chemical toxicity information. The in silico Quantitative Structure Activity Relationship (QSAR) models can use the existing experimental data information to predict the missing chemical toxicity information data and thus reduce animal testing. In the present study, a global QSAR model for the prediction of acute Daphnia magna toxicity has been developed based on the five principles proposed by the Organization for Economic Co-operation and Development (OECD). Moreover, a Daphnia-minnow (referring specifically to the fathead minnow) Quantitative Toxicity–Toxicity Relationship (QTTR) prediction model has been developed based on the present study and our previous work on fathead minnow (Pimephales promelas). Both the QSAR and QTTR prediction models have good goodness-of-fit, robustness, and predictive ability. Finally, the acute toxicity mode of action (MOA) for fathead minnow and Daphnia magna was compared by toxicity ratio based on interspecies toxicity data. By comparison, Daphnia magna was found more sensitive to anilines and phosphorothioates than fathead minnow. The present models can fill the acute toxicity data gap and contribute to the chemicals risk assessment and priority setting.
Fourier analysis of multi-tracer cosmological surveys
Creators: name: Abramo, L. Raul
name: Secco, Lucas F.
name: Loureiro, Arthur
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present optimal quadratic estimators for the Fourier analysis of cosmological surveys that detect several different types of tracers of large-scale structure. Our estimators can be used to simultaneously fit the matter power spectrum and the biases of the tracers - as well as redshift-space distortions (RSDs), non-Gaussianities (NGs), or any other effects that are manifested through differences between the clusterings of distinct species of tracers. Our estimators reduce to the one by Feldman, Kaiser & Peacock (ApJ 1994, FKP) in the case of a survey consisting of a single species of tracer. We show that the multi-tracer estimators are unbiased, and that their covariance is given by the inverse of the multi-tracer Fisher matrix (Abramo, MNRAS 2013; Abramo & Leonard, MNRAS 2013). When the biases, RSDs and NGs are fixed to their fiducial values, and one is only interested in measuring the underlying power spectrum, our estimators are projected into the estimator found by Percival, Verde & Peacock (MNRAS 2003). We have tested our estimators on simple (lognormal) simulated galaxy maps, and we show that it performs as expected, being either equivalent or superior to the FKP method in all cases we analyzed. Finally, we have shown how to extend the multi-tracer technique to include the 1-halo term of the power spectrum.
description: 20 pages, 5 figures. Comments are welcome
Lepton Flavor Violating Radiative Decays in EW-Scale $ν_R$ Model: An Update
Creators: name: Hung, P. Q.
name: Le, Trinh
name: Tran, Van Que
name: Yuan, Tzu-Chiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We perform an updated analysis for the one-loop induced lepton flavor violating radiative decays $l_i \to l_j γ$ in an extended mirror model. Mixing effects of the neutrinos and charged leptons constructed with a horizontal $A_4$ symmetry are also taken into account. Current experimental limit and projected sensitivity on the branching ratio of $μ\to e γ$ are used to constrain the parameter space of the model. Calculations of two related observables, the electric and magnetic dipole moments of the leptons, are included. Implications concerning the possible detection of mirror leptons at the LHC and the ILC are also discussed.
description: 9 figures, 36 single-side pages. Updated email addresses and reference
Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004–2010
Creators: name: Freedman, Rachel A.
name: Alexander, G. Caleb
name: Keating, Nancy L.
name: Dusetzina, Stacie B.
name: Huskamp, Haiden A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Nearly a decade ago, researchers identified a potential interaction between tamoxifen and strong CYP2D6 inhibitors, including several frequently used antidepressants. Based on evidence available at that time, a United States Food and Drug Administration advisory committee recommended tamoxifen’s label be changed in October 2006, noting that postmenopausal women with estrogen receptor-positive breast cancer who are poor CYP2D6 metabolizers by genotype or drug interactions may be at increased risk of cancer recurrence. The impact of accumulating drug risk information on antidepressant use is unknown.
Testing Lorentz symmetry with planetary orbital dynamics
Creators: name: Hees, Aurélien
name: Bailey, Quentin G.
name: Poncin-Lafitte, Christophe Le
name: Bourgoin, Adrien
name: Rivoldini, Attilio
name: Lamine, Brahim
name: Meynadier, Frédéric
name: Guerlin, Christine
name: Wolf, Peter
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Planetary ephemerides are a very powerful tool to constrain deviations from the theory of General Relativity using orbital dynamics. The effective field theory framework called the Standard-Model Extension (SME) has been developed in order to systematically parametrize hypothetical violations of Lorentz symmetry (in the Standard Model and in the gravitational sector). In this communication, we use the latest determinations of the supplementary advances of the perihelia and of the nodes obtained by planetary ephemerides analysis to constrain SME coefficients from the pure gravity sector and also from gravity-matter couplings. Our results do not show any deviation from GR and they improve current constraints. Moreover, combinations with existing constraints from Lunar Laser Ranging and from atom interferometry gravimetry allow us to disentangle contributions from the pure gravity sector from the gravity-matter couplings.
description: 12 pages, 2 figures, version accepted for publication in Phys. Rev. D
แนวทางการส่งเสริมการมีส่วนร่วมของพระสอนศีลธรรม ในการพัฒนาเบญจศีล เบญจธรรม ของนักเรียนประถมศึกษาในสถานศึกษา อำเภอบึงนาราง จังหวัดพิจิตร
Creators: name: พระอธิการเกียรติศักดิ์ กตทีโป
Publisher: name: มหาวิทยาลัยมหาจุฬาลงกรณราชวิทยาลัย วิทยาเขตนครสวรรค์
Year: 2022
Subjects: แนวทางการส่งเสริม
การมีส่วนร่วม
การพัฒนา
เบญจศีล เบญจธรรม

description: The Journal of Research and Academics, 5, 5, 1-ธ.ค.
title: Role of MDTC imaging in sacral tumors
Creators: name: BIgnardi, Elio
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Diagnostic procedure
subject: CT
subject: Bones

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The aim of this retrospective study was to evaluate MDTC imaging in patients with sacral tumors. A wide variety of tumors can involve the sacrum. All the structures of the sacrum can cause tumor : bone, cartilage, nerves, notochord...