cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment
Creators: name: Li, Guofei
name: Zhao, Limei
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Tumor microenvironment is closely related to the occurrence and development of liver cancer. Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment promoting tumor deterioration and metastasis by inhibiting immune cells. Previous studies showed that PI3Kγ inhibitor could reverse the phenotype of TAMs, relieve immunosuppression and sensitize chemotherapy drugs, suggesting that the combination of PI3Kγ inhibitor and chemotherapeutics is likely to bring new breakthroughs in the treatment of liver cancer. Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Pharmacokinetic study showed that the prepared micelles had longer half-life than that of the free drug solutions, which was favorable for high propensity of extravasation through tumor vascular fenestrations. Under low pH and high α-amylasereductive conditions, micelles could depolymerize quickly due to the sensitivity of bonds and enhance significantly cytotoxic activity against Hep-3B liver cancer cell. Additionally, micelles demonstrated higher levels of antitumor efficiency and better tolerance against nude mouse with Hep-3B cell than the free drug solutions. These findings reveal that HES-TG100-115-CDM-PEG micelles are a promising drug delivery system in clinical comprehensive therapy of liver cancer.
Acidente Vascular Cerebral Isquémico num Lactente Filho de Mãe Vegana
Creators: name: Amaral, Joana
name: Ezequiel, Marta
name: Luís, Catarina
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: O acidente vascular cerebral é uma doença rara na infância (2,7 por 100 000 crianças por ano). A hiperhomocisteinemia é um fator de risco independente para a aterosclerose prematura, sendo habitualmente secundário a mutações na enzima metiltetrahidrofolato redutase ou défice de vitamina B12, na idade pediátrica. Descreve-se o caso clínico de um lactente de 10 meses, observado no serviço de urgência por queda da própria altura, com diminuição dos movimentos espontâneos do hemicorpo esquerdo e com postura flexora do membro superior esquerdo. A tomografia computorizada realizada na admissão mostrava imagens de hipodensidade nos corpos estriados bilaterais, e a ressonância magnética lesões isquémicas nas áreas das artérias lentículo-estriadas externas. Analiticamente apresentava aumento da homocisteína sérica (25,2 μmol/L) e défice de vitamina B12 (< 150 pg/mL). A mãe apresentava igualmente défice de vitamina B12, associado a dieta vegana. Foi feita suplementação com vitamina B12, iniciada a diversificação alimentar com introdução da carne, verificando-se normalização dos níveis de homocisteína sérica. Após seis meses de cumprimento do plano terapêutico de medicina física e de reabilitação não eram objetiváveis assimetrias sequelares. A dieta vegana pode associar-se a défices nutricionais que obrigam a uma vigilância nutricional por um profissional experiente, nos casos em que esta seja a opção materna durante a gravidez, sobretudo se prolongada no período de aleitamento materno, e/ou na criança ou adolescente.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 1 (2018)
Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers
Creators: name: Mendes, Livia P.
name: Sarisozen, Can
name: Luther, Ed
name: Pan, Jiayi
name: Torchilin, Vladimir P.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Inorganic Chemistry

description: Modification of nanoparticle surfaces with PEG has been widely considered the gold standard for many years. However, PEGylation presents controversial and serious challenges including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of the nanoparticles. We report the development of novel liposomal formulations surface-modified with a low molecular weight, branched polyethyleneimine (bPEI)–lipid conjugate for use as an alternative to PEG. The formulations had very good stability characteristics in ion- and protein-rich mediums. Protein adsorption onto the liposomal surface did not interfere with the cellular interaction. bPEI-modified liposomes (PEIPOS) showed enhanced association with three different cell lines by up to 75 times compared to plain or PEGylated liposomes and were without carrier toxicity. They also penetrated the deeper layers of 3D spheroids. Encapsulating paclitaxel (PTX) into PEIPOS did not change its main mechanism of action. PEIPOS complexed and intracellularly delivered siRNAs and downregulated resistance-associated proteins. Finally, tumor growth inhibition was observed in a mouse ovarian xenograft tumor model, without signs of toxicity, in animals treated with the siRNA/PTX co-loaded formulation. These complex-in-nature but simple-in-design novel liposomal formulations constitute viable and promising alternatives with added functionality to their PEGylated counterparts.
Large eddy simulations of coal jet flame ignition using the direct quadrature method of moments
Creators: name: Pedel, Julien
Publisher: name: University of Utah
Year: 2012
Subjects: Cfd
Coal
Direct quadrature method of moments
Dqmom
Large eddy simulation
Particles

description: The Direct Quadrature Method of Moments (DQMOM) was implemented in the Large Eddy Simulation (LES) tool ARCHES to model coal particles. LES coupled with DQMOM was first applied to nonreacting particle-laden turbulent jets. Simulation results were compared to experimental data and accurately modeled a wide range of particle behaviors, such as particle jet waviness, spreading, break up, particle clustering and segregation, in different configurations. Simulations also accurately predicted the mean axial velocity along the centerline for both the gas phase and the solid phase, thus demonstrating the validity of the approach to model particles in turbulent flows. LES was then applied to the prediction of pulverized coal flame ignition. The stability of an oxy-coal flame as a function of changing primary gas composition (CO2 and O2) was first investigated. Flame stability was measured using optical measurements of the flame standoff distance in a 40 kW pilot facility. Large Eddy Simulations (LES) of the facility provided valuable insight into the experimentally observed data and the importance of factors such as heterogeneous reactions, radiation or wall temperature. The effects of three parameters on the flame stand-off distance were studied and simulation predictions were compared to experimental data using the data collaboration method. An additional validation study of the ARCHES LES tool was then performed on an air-fired pulverized coal jet flame ignited by a preheated gas flow. The simulation results were compared qualitatively and quantitatively to experimental observations for different inlet stoichiometric ratios. LES simulations were able to capture the various combustion regimes observed during flame ignition and to accurately model the flame stand-off distance sensitivity to the stoichiometric ratio. Gas temperature and coal burnout predictions were also examined and showed good agreement with experimental data.
Sonnenfleckenzeichnung Nr. 23453.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: Global Tuberculosis Spending 2000-2017
Creators: name: Institute for Health Metrics and Evaluation (IHME), World Health Organization (WHO)
Publisher: name:  Institute for Health Metrics and Evaluation (IHME)
Year: 2020

description: Research by the Global Burden of Disease Health Financing Collaborator Network estimated tuberculosis spending for 134 low- and middle-income countries for 2000-2017. The estimates cover tuberculosis spending disaggregated by source into three domestic financing source categories (government, out-of-pocket, and prepaid private) and development assistance for health (DAH). Spending is also disaggregated by function, including care and treatment, prevention, and other spending. Domestic tuberculosis spending by source and function was estimated based on data from sources including the WHO Global Tuberculosis database, the Global Fund, WHO National Health Accounts and sub-accounts, WHO Global Health Expenditure database (GHED), National Tuberculosis Reports, and Ministry of Health Reports. Development assistance for tuberculosis data were drawn from IHME's 2019 Development Assistance for Health Database. Estimates are reported in constant 2019 United States dollars.
Improving cellular uptake of therapeutic entities through interaction with components of cell membrane
Creators: name: Zhang, Renshuai
name: Qin, Xiaofei
name: Kong, Fandong
name: Chen, Pengwei
name: Pan, Guojun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. The cellular uptake of macromolecules and drug carriers is very inefficient without external assistance. Therefore, it is desirable to develop potent delivery systems for achieving effective intracellular delivery of chemic entities. Apart from of the types of delivery strategies, the composition of the cell membrane is critical for delivery efficiency due to the fact that cellular uptake is affected by the interaction between the chemical entity and the plasma membrane. In this review, we aimed to develop a profound understanding of the interactions between delivery systems and components of the plasma membrane. For the purpose, we attempt to present a broad overview of what delivery systems can be used to enhance the intracellular delivery of poorly permeable chemic entities, and how various delivery strategies are applied according to the components of plasma membrane.
Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment
Creators: name: Li, Guofei
name: Zhao, Limei
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Tumor microenvironment is closely related to the occurrence and development of liver cancer. Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment promoting tumor deterioration and metastasis by inhibiting immune cells. Previous studies showed that PI3Kγ inhibitor could reverse the phenotype of TAMs, relieve immunosuppression and sensitize chemotherapy drugs, suggesting that the combination of PI3Kγ inhibitor and chemotherapeutics is likely to bring new breakthroughs in the treatment of liver cancer. Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Pharmacokinetic study showed that the prepared micelles had longer half-life than that of the free drug solutions, which was favorable for high propensity of extravasation through tumor vascular fenestrations. Under low pH and high α-amylasereductive conditions, micelles could depolymerize quickly due to the sensitivity of bonds and enhance significantly cytotoxic activity against Hep-3B liver cancer cell. Additionally, micelles demonstrated higher levels of antitumor efficiency and better tolerance against nude mouse with Hep-3B cell than the free drug solutions. These findings reveal that HES-TG100-115-CDM-PEG micelles are a promising drug delivery system in clinical comprehensive therapy of liver cancer.
Canadian Gallup Poll # 504-1
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Federal election vote intent(1); past federal elections vote(1); greatest problem facing Canada(1); greatest threat to Canada: big business, labor or government(1); public schools in the community(1); labor unions(2); mandatory retirement(1). Note: Demographics(17).
Sonnenfleckenzeichnung Nr. 23385.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Role of dorsal CA3 recurrent collaterals in cue-induced pattern completion leading to relapse into drug taking and drug seeking behaviors
Creators: name: Clark, Jascha Kennedy
Publisher: name: University of Utah
Year: 2012
Subjects: Drug abuse - Relapse - Treatment
Drug abuse - Treatment
Hippocampus (Brain) - Effect of drugs on

description: In the contest of drug addiction, relapse is defined as the return to drug seeking and drug taking behavior after a prolonged period of abstinence. Relapse is a serious problem that still requires extensive research in order to generate sufficient knowledge of the mechanisms that mediate it. Often, the role of craving is cited as a primary motivating factor for relapse. One possible mechanism that could support this observation is known as pattern completion, a process wherein presentation of an incomplete stimulus complex reinstates the complete, previously learned pattern. It has been proposed that during retrieval of information, the dorsal CA3 recurrent collaterals of the hippocampus play a major role in retrieving complete previously learned patterns in the face of an incomplete stimulus complex input to the hippocampus (pattern complietion).  Support for the operation of a pattern completion process is based on a spatial pattern completion task in which-the effects of naloxone injections into the dorsal CA3 sub-region of the hippocampus revealed impairment of pattern completion in the presence of varying numbers of available cues. We used a variant of the conditioned place-preference task in which the number of available cues was parametrically adjusted to assess the role of pattern completion in cue-induced reinstatement of drug-seeking behavior and to determine whether disruption of pattern completion secondary to infusion of naloxone into the dorsal CA3 region disrupts cue-induced reinstaement. Results indicate that naloxone will disrupt the reinsta tement (preference for cocaine conditioned cues over saline conditioned cues) for one cue, but not for all four cues, suggesting a significant impact on pattern completion within the dorsal CA3 region.
Sonnenfleckenzeichnung Nr. 23358.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 31.05.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The relationship between social psychological climate and psychological well-being in late adolescent dancers
Creators: name: Stark, Andrea
Publisher: name: University of Utah
Year: 2012
Subjects: Adolescent dancers
Body-esteem
Friendship
Positive and negative affect
Psychological well-being
Social psychological climate

description: Studies of dancers have indicated they experience a variety of psychological issues including low body satisfaction, low self-esteem, and poor mood. Researchers have suggested that perceptions of the dance climate may impact psychological well-being and have concluded that promoting task-involving climates is beneficial to dancers' well-being. Other researchers have suggested that caring climates are integral to optimizing well-being. However, perceptions of a caring climate have not been examined in dance studios and little is known about the relationship between perceptions of a broader climate and aspects of psychological well-being. Additionally, no studies have examined whether types of dance studios (competitive or technical) influence dancers' experiences of the climate or their well-being. The purpose of this study was to examine the relationship between perceptions of the social psychological climate (task-involving, ego-involving, and caring) and aspects of psychological well-being (positive and negative affect, body-esteem, and teacher and peer friendship quality) in both technical and competitive adolescent dancers. Eighty-three female dancers (M age = 16.28 +/- .93) completed questionnaires regarding perceptions of their studio's dance climate and self-reported well-being. Competition dancers perceived their dance climate to be more task-involving, more caring, and less ego-involving and reported higher levels of psychological well-being (positive affect, body-esteem, and friendship) than technical dancers. Dancers' overall perceptions of task-involving and caring climates were related to higher positive affect, greater body-esteem, and better quality relationships with teachers and peers (r range: .33 - .68). A second order factor analysis of the subscale scores revealed two factors. The first factor, exemplifying a thriving climate, accounted for 47.93% of the variance and involved aspects of a positive climate and positive well-being. The second factor, characterizing a threatening climate, accounted for an additional 14.70% of the variance and included an ego-involving climate and negative loadings on well-being. Results demonstrate perceptions of a positive social psychological climate are vital to promoting psychological well-being in adolescent dancers. These findings suggest dance teachers should be considerate of the impact the climate has for promoting well-being in their dance students. Educating dance teachers to create such a climate should be included in any dance pedagogy program.
Sonnenfleckenzeichnung Nr. 23471.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.09.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Development of an intravaginal ring delivering simultaneously anastrozole and levonorgestrel: a pharmacokinetic perspective
Creators: name: Nave, Rüdiger
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Intravaginal rings (IVRs) are an option for continuous administration of drugs in women. As an attractive approach for the treatment of endometriosis-associated pelvic pain, IVRs delivering a combination of the aromatase inhibitor anastrozole (ATZ) and the progestin levonorgestrel (LNG) have been developed. This article describes the developmental pharmacokinetic (PK) aspects covering the characterization of in vitro release, preclinical IVR PK investigations in monkeys, and clinical PK considerations. An IVR for ATZ has been developed and investigated in healthy menstruating female cynomolgus monkeys showing effective in vivo release. PK data from the size-adapted IVR used in these animals can be translated into a human context as confirmed in human studies where predefined exposure levels of ATZ were reached. As ATZ may cause harm to the fetus, use of effective contraception has to be assured in women of childbearing potential. Therefore, the IVR delivers a low dose of LNG as a contraceptive. Although the daily dose differed strongly between both drugs (20 µg LNG/d to >1 mg ATZ/d), simultaneous delivery of ATZ and LNG in vitro and in vivo was observed with a high correlation between the in vitro release and PK profiles. The PK characteristics successfully guided the design of clinical studies investigating the drug–drug interaction (DDI) potential. No relevant DDI between both the investigated or other vaginally administered drugs were identified.
An inverse acoustical phased array technique for impact detection and location
Creators: name: Papulak, Tyler Steven
Publisher: name: University of Utah
Year: 2012
Subjects: Composites
Impact detection and location
Large structures
Modal acoustic emissions
Phased array
Structural health monitoring

description: Due to the complex failure modes associated with composites, a structural health monitoring system capable of accurately locating the source of strength-reducing events is desirable in order to reduce inspection time and time out of service. Various active and passive inspection techniques exist but most require large footprints and extensive cabling to monitor full scale structures. This work derives various location techniques by coupling modal acoustic emissions with phased array techniques to detect and accurately locate the source of strength-reducing events such as impacts. Phased array techniques provide a method to more accurately track phase points for determining arrival times used to back-calculate the source, as well as providing a method that can incorporate anisotropic wave speeds. To increase accuracy by neglecting local to global material changes, the local velocity profile per component was found and built into the derived location algorithms. The location algorithms were then tested on two full scale composite structures based on strength and stiffness critical design considerations. It was found that with two arrays, each with dimensions of 1 inches in width and 8 inches in length and consisting of four sensors each, events could be accurately located over a 65 ft2 region on the stiffness critical structure with an average error of 10 inches and over a 100 ft2 region on the strength critical structure with an average error of 9 inches.
Sonnenfleckenzeichnung Nr. 23431.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.08.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23495.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.10.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Hidroxiureia (Hidroxicarbamida) na Doença de Células Falciformes
Creators: name: Baptista, Rute Baeta
name: Maia, Raquel
name: Batalha, Sara
name: Fernandes, Ricardo M
name: Kjöllerström, Paula
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
In Vivo Characterization of Pituitary Adenylate Cyclase-Activating  Polypeptide in Mouse Olfactory Epithelium
Creators: name: Stamm, Michelle L.
Publisher: name: University of Utah
Year: 2014

description: The study of neurogenesis is important for understanding the causes of many developmental defects, and crucial for the prevention and treatment of neuronal degeneration and injury. The olfactory system is an excellent model for the study of neurogenesis due to its unique ability to continuously regenerate olfactory sensory neurons (OSNs), even in adults. Pituitary adenylate cyclaseactivating polypeptide (PACAP) functions in many aspects of neurogenesis and is present in the olfactory epithelium (OE). We examined the role of PACAP, in vivo, in the development and regeneration of the OE by comparing PACAP knock-out (KO) and wild-type (WT) mice. In early postnatal development, proliferation levels are reduced in PACAP KO mice but the number of OSNs is not different from WT mice. By 1 week of age, no differences between PACAP KO and WT mice were observed. Given that other growth factors may be present during development and could compensate for the absence of PACAP, we also examined adult OE. Although adult PACAP KO mice have normal food odorant detection, the OE exhibits decreased epithelial thickness due to loss of cells. However, immunostaining revealed no differences in OSN numbers between PACAP KO and WT mice, although expression levels for markers of OSNs were increased. Surprisingly, PACAP KO mice show increased proliferation compared to WT mice. Injury-induced degradation, resulting in iv regeneration of the OE, was also examined in adult PACAP KO and WT mice. Immediately after chemical insult, PACAP KO mice exhibited more inflammation than WT mice. A faster decline in OSNs, leading to quicker onset of anosmia, was seen in PACAP KO mice. In addition, PACAP KO mice recovered from anosmia more quickly, likely due to increased proliferation levels before insult. However, 1 week following insult there were no differences between PACAP KO and WT mice, and both groups were recovered functionally after 2 weeks. We conclude that PACAP has a minor influence promoting proliferation during OE development. PACAP is not required for adult proliferation, but is required for the survival and maintenance of adult OE. This study suggests PACAP may be important for future therapies aimed at promoting neuronal survival.
Sonnenfleckenzeichnung Nr. 23507.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.11.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 23355.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.05.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Case study of turbulent fluxes during a wintertime persistent cold air pool in the Salt Lake Valley
Creators: name: Sriramasamudram, Jai K
Publisher: name: University of Utah
Year: 2012
Subjects: Cold air pool
Inversion
Meterology
Persistent cold air pool
Turbulence

description: Local turbulence processes during the formation, maintenance and destruction of persistent cold air pools are relatively unknown. A wide variety of mechanisms are involved in the formation and destruction of persistent cold air pool that contribute to this problem. In this work, two persistent cold air pool episodes were observed during February 2004 in the Salt Lake valley. The two inversion episodes were separated by a  brief ‘washout' period when the persistent cold air pool was destroyed. The current research presents near surface turbulence measurements including fluxes of heat, momentum and water vapor during February 2004 from a measurement site located at the southwest end of the Salt Lake valley. The turbulence levels during the persistent cold air pool episodes compared to turbulence during a period that was not under the influence of  a cold air pool were reduced by over 70%. Meteorological data from various regional weather monitoring stations have been utilized to conjecture two types of mixing scenarios during a persistent cold air pool namely, a surface based inversion scenario and  a well-mixed surface layer capped by an elevated inversion. It is shown that both of these types of cold air pools can exist during a single persistent cold air pool episode.
Sonnenfleckenzeichnung Nr. 23460.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.09.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Brief an [Johann Bernoulli]
Creators: name: Ludwig Eugen
Publisher: name: [s.n.]
Year: 1782

description: von Ludwig [Eugen] von W[ürttemberg]
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Experience of pregnancy among Hispanic women
Creators: name: White, Vivian K.
Publisher: name: University of Utah
Year: 2012
Subjects: Cross-Cultural Comparison

description: The purpose of this research was to explore the Hispanic women's first experience of pregnancy.  The investigation was a descriptive study of 10 nulliparous women who considered themselves Hispanic.  Each informant was interviewed twice during the last month of pregnancy.  An open ended interview schedule was designed to answer the research questions.  Utilizing the grounded theory approach addition topic areas emerged as being important to the sample and was explored in subsequent interviews.  The findings indicate that becoming a mother us an important step in the lives of Hispanic women.  The women interviews described the pregnancy as a time for growth in which they often turned to their mothers for support and advice.  The majority of the women had heard of the traditional childbirth practices and expressed a tendency to adhere to these practices.  Knowledge of these traditional practices will enable nurse to provide culturally sensitive care
Sonnenfleckenzeichnung Nr. 23434.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.08.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Health status and problems managing physical health among chronically mentally ill outpatients: a descriptive and correlational study
Creators: name: Bjork, Marilynne R.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Bibliography
subject: Psychology
subject: FOS: Psychology
subject: Self Care
subject: Psychiataric Nursing

description: A comprehensive evaluation of 25 chronically mentally ill Day Treatment Center patients revealed 140 functional health problems. Fifty-six (40%) of these health problems were considered to have a potentially major impact upon life and functioning of the individual. Twenty-one patients (84%) were found to have at least one major functional health problem, and 72% (n = 18) to have more than one major problem. Minor functional health problems were identified in 100% of the patients. A majority of the health problems identified in this study (69%, n = 96) were either undiagnosed or untreated at the time of the study. This finding highlights a need for comprehensive health assessments to be regularly provided to this population. Each of the potential barriers to obtaining and managing physical health care was endorsed by some of the patients. The significant correlations relating to health and health care management are discussed. Potential ways of helping chronically mentally ill patients access, obtain, and follow through with physical health care are discussed.
Descriptio observatorii Gedanensis
Creators: name: Wolf, Nathanael Matthias von
Publisher: name: [s.n.]
Year: 1724

description: von [Nathanael Matthias von Wolf]
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis
Úlceras de Lipschütz - Do Dogma à Realidade
Creators: name: Vieira-Baptista, Pedro
name: Lima-Silva, Joana
name: Soares, Henrique
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Lemos com o maior interesse o artigo intitulado “Úlcerade Lipschütz na Adolescência: Um Desafio Diagnóstico”. Antes de mais, congratulamos os autores pela abordagem de um tema tão pouco conhecido entre a pediatria, a ginecologia e a dermatologia, bem como pela magnífica descrição do caso e metodologia diagnóstica aplicada.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Carta ao Editor - Conjuntivite Neonatal. Que (Não) Profilaxia?
Creators: name: Serras, Inês
name: Candeias, Flora
name: João Brito, Maria
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: A conjuntivite neonatal ocorre nas primeiras quatro semanas de vida sendo as causas infeciosas adquiridas durante a passagem pelo canal do parto as mais frequentes.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Preliminary investigations of Eosinophil Cationic Related Protein, a putative eosinophil granule protein.
Creators: name: Frost, Marisa Antónia
Publisher: name: University of Utah
Year: 2012
Subjects: Proteins
Antibodies

description: Eosinophils play a dual role in the hose immune response.  Whereas considerable evidence exists that are effective in defending the host against parasite infections, they also play an important role in the inflammatory pathology resulting from parasitic infections and allergic reactions.  De-granulation of the eosinophil and release of its cytotoxic proteins are important both in the host defense and inflammation.  For example, the granule proteins are toxic to parasites as well as normal host tissue.  Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are ribonucleases of the eosinophil granule.  We report on studies of a putative novel protein in the eosinophil granules isolated from lysates of human eosinophil granules from a patient with hypereosinophilic syndrome.  This putative protein is named Eosinophil Cationic Related Protein (ECRP).  We attempted to isolate ECRP from the granule lysates by get filtration and ion exchange chromatography.  Chemiluminescent immunodection using polyclonal antibodies revealed a band on western blots which reacted to ECRP antibodies.  The sequence homology, conservation of known functional sites, and chromosomal mapping to the same region in chromosome 14 as EDN and ECP strongly suggest that ECRP is also a ribonuclease with functions similar to both ECN and ECP.  RCEP has a predicted weight of 14.7KDs and a predicted PI of 9.72.  ECRP has 90% identity to EDN in sequence homology.  The putative ECRP appears to have an open reading frame that is transcriptional active in response to IL-5.  Furthermore, ICRP antibodies reacting to granule lysates suggests that the ECRP protein is likely to be present in eosinophil granules.
Testamentabschrift
Creators: name: Wolf, Nathanael Matthias von
Publisher: name: [s.n.]
Year: 1784

description: von Nathanael Matthias v. Wolf
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Computer-based audio-response system for clinical medicine
Creators: name: Johnson, David Kay
Publisher: name: University of Utah
Year: 2012
Subjects: Clipped Speech Synthesizer
LDS Hospital
Audio Response System

description: The history of talking machines is briefly reviewed.  Speech can be infinitely clipped until only zero-crossing information of the original speech signal remain and still be reasonable intelligible.  The feasibility of using clipped speech as a means of implementing and economical Audio Response System from a computer is explored.  A means of compressing clipped speech data is described that uses an average zero-crossing scheme without affecting intelligibility.  A six-bit word was chosen to represent the compressed clipped speech data.  With this technique, average storage for a spoken word is 200 24-bit computer works.  The output rate from the computer to synthesize intelligible speech is 130 24-bit words per second.  Synthesis of clipped speech can be done with a digital computer but to make a practical system, special purpose hardware was designed and constructed.  It is called the Clipped Speech Synthesizer (CSS).  The CSS comprised of a core memory into which the computer can dump clipped speech data a high rate, logic circuits to control the access to the memory and a counter to generate the zero-crossing time-intervals for the reconstructed clipped speech signal.  Detailed operation of this equipment is presented.  A prototype, Audio Response System in now in operation at the LDS Hospital in Salt Lake City, Utah.  The vocabulary is currently about 100 spoken words but expansion to more is simply a matter of allocating the storage and recording the works.  Spoken messages are synthesized under program control and can be transmitted to any location there is a telephone.  Present capabilities of the system allow synthesis and output of a patient's blood chemistry data to any dial -type telephone.  The access and output of additional patient data is simply a matter of programming.  To use the system, a physician dials a telephone in the computer facility at the LDS Hospital.  The telephone is automatically answered and a message is synthesized and transmitted to the caller asking for his ID number.  Upon receiving the correct physician ID number, a message is synthesized and transmitted asking for a patient ID number.  The physician then dials his patient's ID number.  The computer checks whether a patient record with this number is in the current file.  If not, the physician and patient number are synthesized and transmitted to the caller along with a message informing him that there is no such patient number.  The call in then terminated.  If the patient number is valid, the patient number is synthesized and sent to the caller for positive identification.  The latest blood chemistry data on that patient are then retrieved and sent to the physician.
Amioplasia Congénita: Caso Clínico
Creators: name: Esteireiro, Ana
name: Carreira, Raquel
name: Moldovan, Oana
name: Bicho, Anabela
Publisher: name: Portuguese Journal of Pediatrics
Year: 2017

description: Recém-nascido do sexo masculino, filho de pais não consanguíneos e saudáveis. Gestação gemelar monocoriónica e bi-amniótica, mal vigiada, com serologias e ecografias (às 20 e 31 semanas) sem alterações.
description: Portuguese Journal of Pediatrics, Vol. 48 No. 4 (2017)
Brief an [Johann Christoph von] Woellner
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1789

description: von Johann Bernoulli
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Astronomische Beobachtungen aus den Jahren 1744-1784
Creators: name: Wolf, Nathanael Matthias von
Publisher: name: [s.n.]
Year: 1785

description: von [Nathanael Matthias] von Wolf
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 214: Ergänzung von Johann III Bernoulli
Brief an [Johann Bernoulli]
Creators: name: Wettstein, Johann Heinrich
Publisher: name: [s.n.]
Year: 1781

description: von [Johann Heinrich] Wettstein
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Februar 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog