cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Solid-state NMR investigation of the metastasis-inducing protein matrilysin
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Matrilysin, which is overexpressed in many human cancers, is a matrix metalloproteinase (MMP) that cleaves a variety of proteins on the cell surface and in the extracellular matrix. Because of this diversity of function, MMPs play a role in many processes such as tissue differentiation and wound healing, as well as being implicated in pathologies like arthritis and cancer. In particular, matrilysin contributes to the metastasis of colon cancer 1. Matrilysin-mediated aggregation has been observed in vitro using human colon cancer cells, and also in a nude mouse model of colon cancer metastasis 3. It has recently been shown that matrilysin interacts with the cell surface by binding to cholesterol sulfate 4, which is ubiquitous in biological membranes. Previous structural studies of matrilysin have used X-ray crystallography to obtain the structure of the protein complexed with different inhibitors 5. The objectives of this project are twofold: to identify the residues of matrilysin involved in cholesterol sulfate binding as a guide to future mutagenesis studies, and to investigate the structure of cholesterol sulfate-bound matrilysin in a membrane environment. The insights gained may lead to treatment strategies that focus on inhibition of cholesterol sulfate binding, rather than blocking of the active site, which could interfere with the legitimate biological function of matrilysin and lead to unwanted side effects. Preliminary results have been obtained indicating the applicability of solid-state NMR to protein structures, and the utility of switched-angle spinning NMR in studies of oriented molecules. This project will combine aspects of these successful methodologies to investigate the structure and membrane association of matrilysin bound to cholesterol sulfate. We will use projected magic angle spinning (p-MAS) to measure an isotropic spectrum correlated with the anisotropic interactions measured at two different spinning angles. This will extend the currently widely used residual dipolar coupling measurements into the regime of strongly oriented samples. 13C-15N correlations between 15N-matrilysin and 13C- cholesterol sulfate will identify the residues responsible for membrane association, as a guide for future mutagenesis studies. Uniformly labeled 13C-15Nmatrilysin will be used to obtain detailed structural information about cholesterol sulfatebound matrilysin in a membrane environment.
Threading the loop: a novel approach to anti-cancer agent sungsanpin
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lasso peptides possess a unique topology that includes a threaded loop (i.e., a linear tail that is feed through a central peptide ring). This unique conformation improves cell permeability, metabolic stability, and target recognition. Recently isolated from a marine bacteria, sungsanpin is a lasso peptide that displays cytotoxic activity against human lung cancer. To date, no synthetic strategy exists to access lasso peptide structures, which warrant further study due to their unique structure and compelling medicinal properties. The following proposal details three synthetic approaches to access this novel class of unexplored therapeutics. We plan to prepare sungsanpin and related lasso peptidomimetics by: (A) fragmentation of a bridged bicyclic peptide through a phosphate-promoted ligation, (B) metal-catalyzed ligation of functionality on a cyclic peptide with an external coupling partner, and (C) cyclization of a preorganized dehydropeptide. Our proposed synthetic routes derive from my laboratories unique perspective and background, which encompasses the fields of supramolecular chemistry, peptide synthesis, and organometallic catalysis. Once an ideal route to the lasso architecture is established, we will synthesize more potent lasso peptide analogues based on structure activity relationship (SAR) studies. These studies will enable access to a novel and promising class of peptides for the study and treatment of human lung cancer and other strains.
Annual report of the Shade Tree Division of the city of Newark, New Jersey for the year ending December 31, 191&
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1917

description: A yearly series of reports from the Newark Shade Tree Commission which covers planting, care, and inventory of shade trees in the city of Newark, New Jersey. Other topics include maintenance, insect control, nurseries, and parks.
A facile and versatile polyvalent drug-targeting system for cancer treatment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Leukemia is one of the 10 most common cancers in the United States. Current chemotherapeutic drugs lack selectivity and are associated with major side-effects and lack of efficacy in many patients. We therefore propose to develop a drug-carry, polyvalent aptamer system to specifically deliver therapeutic agents to leukemia cells. This platform technology will take advantage of the increased avidity and specificity of multivalent binding in the form of multiple aptamers against the leukemia cell marker protein tyrosine kinase 7 (PTK7, overexpressed in up to 70% of some subtypes of leukemia). The polymeric form of aptamers will be generated via rolling circle amplification and will incorporate linker regions in which we will incorporate the chemotherapeutic doxorubicin. In our preliminary data, we have synthesized the polyvalent DNA aptamer complexed with doxorubicin and demonstrated that these polyvalent aptamers specifically bind to target PTK7+ CCRF-CEM cells. In the proposed work, we will investigate 1) the specific binding, 2) internalization, and 3) in vitro cytotoxicity of the polyvalent aptamer loaded with drugs. We anticipate that our approach will yield easily tunable therapeutics that can be utilized to specifically target leukemia and other cancer cells to both more effectively treat cancer and minimize the side effects of systemic chemotherapy.
Cathorops fuerthii
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Cathorops
Cathorops fuerthii

description: Cathorops fuerthii (Steindachner 1876). Congo Sea Catfish; Cuminate, Bagre Congo
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from southern Nicaragua to central Panama; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Ni (Pacific); 0–5 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; DD (2019), population trend unknown. Literature: Robertson & Allen (2015: 582; detailed description, including illustrations, and information on distribution, with a map, and ecology), Angulo (2021: 31; listed, including information on distribution) and Froese & Pauly (2023; listed, including information on identification, distribution and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 29, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Hymenophyllum Sm. (Smith 1793
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Hymenophyllum

description: Genus Hymenophyllum Sm. (Smith 1793)
This pantropical genus (in addition to numerous species in wet temperate areas, especially in southern hemisphere) regroups more than 300 epiphytic (more rarely lithophytic), dwarf to large species with mostly long-creeping filiform rhizomes bearing sparsely distributed roots and pending dissected fronds in addition to sori without developed tubular base (at least for species of the region; Fig. 2A, F). In the Comoros, species belong to three subgenera following Ebihara et al. (2006): Hymenophyllum, Sphaerocionium (C.Presl) C.Chr. and Mecodium C.Presl ex Copel.
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 20, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
title: Diascia :
title: Principes directeurs pour la conduite de l’examen de la distinction, de l’homogénéité et de la stabilité.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: Plants
New Varieties of Plants
Dascia
Jamesbrittenia

description: Ces principes directeurs (“principes directeurs d’examen”) visent à approfondir les principes énoncés dans l’introduction générale (document TG/1/3) et dans les documents TGP qui s’y rapportent afin de donner des indications concrètes détaillées pour l’harmonisation de l’examen de la distinction, de l’homogénéité et de la stabilité (DHS) et, en particulier, à identifier des caractères convenant à l’examen DHS et à la production de descriptions variétales harmonisées.
Tetramorium delagoense Forel, stat. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium delagoense

description: Tetramorium delagoense Forel stat. n.
Tetramorium simillimum st. delagoense Forel, 1894: 80. Syntype workers, queens, males, Mozambique: Delagoa (Dr Liengme) (MHN, Geneva) [examined]. Tetramorium simillimum var. madecassum Forel, 1895 «: 248. Holotype worker, Madagascar: Imerina (Sikora) (MNH, Geneva) [examined]. Syn. n.
Worker. TL 2.3 - 2.8, HL 0.56 - 0.66, HW 0.49 - 0.58, CI 84 - 89, SL 0.42 - 0.52, SI 84 - 92, PW 0.33 - 0.41, AL 0.61 - 0.80 (25 measured).
Mandibles finely sculptured with dense, weak striation or dense shagreening. Anterior clypeal margin entire. Frontal carinae strongly developed, extending back almost to the occiput and distinctly more strongly developed than the remaining cephalic sculpture. Antennal scrobes broad and quite shallow, but distinct. With the head in full-face view the sides immediately behind the eyes with a single short, stout hair projecting anteriorly. Alitrunk in profile usually with a slight indentation at the metanotal groove. Propodeal spines usually short and broadly triangular, sometimes reduced and blunted but never absent, the spines shorter than the metapleural lobes which are themselves broadly triangular in shape. Petiole node in profile somewhat variable in shape but usually the same as in simillimum (Fig. 38). In dorsal view the node broader than long. Dorsum of head longitudinally rugulose, the spaces between rugulae packed with a dense, conspicuous reticulate-punctate ground-sculpture or densely granular. Dorsal alitrunk finely rugulose, with distinct punctulation between the rugulae. Dorsal surfaces of petiole and postpetiole similarly but more faintly sculptured. All dorsal surfaces of head, alitrunk and gaster with scattered short, stout, blunt hairs. Colour yellowish brown to mid-brown.
This small species is a very close sibling of simillimum and was originally described as a variety of it. However, it differs consistently from simillimum by possessing a single projecting stout hair on the side of the head just below the eye, a feature absent from simillimum. Also, the scapes of delagoense tend to be relatively slightly longer, with SI 84 - 92, as opposed to SI 74 - 80 in simillimum.
Although known from Madagascar, delagoense does not appear to be very common there. It is an African species which has spread to Madagascar and it is common in eastern and southern Africa, being known from numerous collections from South Africa, Rhodesia, Angola, Tanzania, Kenya and Sudan.
Material examined
Madagascar: Bekonazy (nr Morondava) (W. L. Brown); Imerintsiatosika (nr. Tananarivo) (W. L. Brown).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 156-157
Light-activated nuclear import to investigate YAP function in epithelial homeostasis and cancerogenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Most cancers are derived from epithelial tissues, and loss of epithelial cell polarity and the associated loss of contact inhibition and increased cell motility are important hallmarks of cancer. The Hippo/YAP signaling pathway was identified as a central control point balancing epithelial polarity and proliferation. YAP is a transcriptional co-activator that is nuclear in proliferating cells and activates transcription of cell proliferation genes. In contact-inhibited cells, YAP is retained in the cytoplasm and inhibited. YAP has also been identified as an oncogene, and is overexpressed in a variety of cancers. However, little is not known about YAP nuclear localization dynamics during growth and development of normal epithelial tissues or in epithelia-derived cancerogenesis. In this pilot proposal, that represents a new direction for my lab, we plan to test how YAP localization controls contact inhibition in a growing apical-basal polarized epithelial structure, and ask whether spatially and temporally controlled YAP nuclear translocation in single cells can overcome contact inhibition and induce tumor formation. This is an important question because intact epithelial structure acts as a barrier against tumor development, and it is unclear how sporadic single cells with oncogenic alterations can develop and disrupt the tightly organized epithelial tissue. We will address these unresolved questions by using innovative live cell microscopy of EGFP-YAP expressing MCF10A mammary epithelial acini in 3D tissue culture. My lab has significant experience in high resolution imaging of 3D epithelial structures, and state-of-the-art spinning disk confocal microscopes are available for this project. In addition, we will use a novel light-activated LOV2-NLS nuclear protein import model that we have recently developed to manipulate YAP localization with high spatial and temporal precision in MCF10A acini to test how this disrupts epithelial polarity and promotes proliferation by itself or in combination with other oncogenes.
Additional file 3: of Predicting high risk births with contraceptive prevalence and contraceptive method-mix in an ecologic analysis
Creators: name: Perin, Jamie
name: Agbessi Amouzou
name: Neff Walker
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional predictions for how birth spacing will change with mCPR ranging between 20 and 80% for similar scenarios are shown for 71 countries. (PDF 1962Â kb)
Chaerilus mainlingensis Di & Zhu 2009
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Chaerilidae
Chaerilus
Chaerilus mainlingensis

description: (3) Chaerilus mainlingensis Di & Zhu, 2009
TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Nyingchi City, Mainling City, Milin Town, Gongbuwang Manor; MHBU (lost).
CHINESE EQUIVALENT. ※林ṅfflx.
DISTRIBUTION (●). Xizang: Nyingchi City (Mainling City: Gongbuwang Manor in Milin Town).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Atlantodesmus teresa
Creators: name: Bouzan, Rodrigo Salvador
name: Iniesta, Luiz Felipe Moretti
name: Brescovit, Antonio Domingos
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Polydesmida
Chelodesmidae
Atlantodesmus
Atlantodesmus teresa

description: Atlantodesmus teresa (Hoffman, 2000)
BRAZIL • 1 ♀; Espírito Santo, Linhares, Reserva Natural Vale do Rio Doce; 40°06′37″ W, 19°13′74″ S; 09–15 Jan. 2012; J.P.P. Pena-Barbosa et al. coll.; IBSP 4106 • 1 ♂; São Mateus Reserva Florestal do Vale do Rio Doce; 39°85′67″ W, 18°71′91″ S; 05–12 Jan. 1998; A.D. Brescovit coll.; IBSP 565.
description: Published as part of Bouzan, Rodrigo Salvador, Iniesta, Luiz Felipe Moretti & Brescovit, Antonio Domingos, 2019, Cladistic analysis and description of a new species of the Brazilian genus Atlantodesmus Hoffman, 2000 (Diplopoda: Polydesmida: Chelodesmidae), pp. 1-17 in European Journal of Taxonomy 538 on page 16, DOI: 10.5852/ejt.2019.538, http://zenodo.org/record/3346493
Additional file 3: of Enhancing Mental and Physical Health of Women through Engagement and Retention (EMPOWER): a protocol for a program of research
Creators: name: Hamilton, Alison
name: Farmer, Melissa
name: Tannaz Moin
name: Finley, Erin
name: Lang, Ariel
name: Oishi, Sabine
name: Huynh, Alexis
name: Zuchowski, Jessica
name: Haskell, Sally
name: Bevanne Bean-Mayberry
Publisher: name: Figshare
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Implementation of Tailored Collaborative Care for Women Veterans (Alison Hamilton (PI) and Ariel Lang (Co-PI)). (DOCX 50Â kb)
Annual report of the Shade Tree Division (Department of Parks and Public Property) of the city of Newark, New Jersey for the year ending December 31, 1918
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1918

description: A yearly series of reports from the Newark Shade Tree Commission which covers planting, care, and inventory of shade trees in the city of Newark, New Jersey. Other topics include maintenance, insect control, nurseries, and parks.
Cathorops melanopus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Cathorops
Cathorops melanopus

description: Cathorops melanopus (Günther 1864). Dark Sea-Catfish; Cuminate, Bagre Prieto
Vouchers: Not available. Distribution: Western Atlantic Ocean; from northern Guatemala to northern Nicaragua; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) UI and WK (Atlantic); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2020), population trend unknown. Literature: Villa (1982: 115, as Arius melanopus —synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Van Tassell (2019: 4467; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 29, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Chaerilus pseudoconchiformus Yin, Qiu, Pan, Li & Di 2015
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Chaerilidae
Chaerilus
Chaerilus pseudoconchiformus

description: (5) Chaerilus pseudoconchiformus Yin, Qiu, Pan, Li & Di, 2015
TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Nyingchi City, Bayi District; USTC.
CHINESE EQUIVALENT. LJffi形ṅfflx.
DISTRIBUTION (●). Xizang: Nyingchi City (Bayi District).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Structure-based inhibitor design and discovery of chemotherapeutics targeted at p53R2, a novel ribonucleotide reductase
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The objective of this proposal is to identify new chemotherapeutics that inhibit a unique ribonucleotide reductase (RNR) called hp53R2. RNR catalyzes the reduction of all four ribonucleotides to their corresponding deoxyribonucleotides (dNTP), the building blocks for DNA biosynthesis. RNR is paramount for cancer cell survival and a validated target for anticancer agents, and currently there are many RNR-targeting anticancer drugs in the clinic or clinical trials. However, the broad specificity of many such RNR inhibitors remains a major shortcoming. Therefore, there is a need to understand the structures and functions of different RNR components so that specific inhibitors can be designed accordingly. In human, the RNR small subunits hp53R2 and R2 are highly homologous. However, hp53R2 and R2 have different biological roles: hp53R2 for p53-dependent DNA repair, and R2 for S-phase dependent DNA replication. Selectively inhibiting hp53R2 (versus R2) will have a high impact on the success of RNR-specific chemotherapeutics for the target cancer cells that exploit the subunits differentially. Our hypothesis is that we can apply the hp53R2 crystal structure and first-generation hp53R2-specific inhibitors to design the next-generation of hp53R2 inhibitors with improved specificity and potency. We based this hypothesis on our preliminary data that we have solved the apo hp53R2 crystal structure, which shows distinct structural features that are significantly different from those in R2, and that we have also identified potent anticancer inhibitors more specific against hp53R2 than R2. These data firmly support the feasibility of the proposed research. The proposal include 3 specific aims: AIM 1. Solve the co-crystal structures of hp53R2 bound to channel-specific inhibitors. AIM 2. Identify next-generation inhibitors in silico and conduct in vitro screens against hp53R2. AIM 3. Determine the anticancer potency of hp53R2 inhibitors in vivo. The proposed research is significant, because the outcomes will provide the first critical comparison between R2 and hp53R2, a clarification of the hp53R2 functions, as well as inhibitors specific for hp53R2. It will also answer important questions about the molecular features of R2 and hp53R2 that are correlated with their distinct biological roles. The CRCC support will help answer important scientific questions about RNR, and will lead to the development of new chemotherapeutics that specifically target at the RNR small subunits.
Sphaerocionium
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Sphaerocionium

description: Subgenus Sphaerocionium
Subgenus Sphaerocionium is clearly distinct in the archipelago with two species characterized by lamina covered by a dense indumentum (see Fig. 2A). By contrast, all other Comorian Hymenophyllum species display glabrous lamina margins. Furthermore, the two Comorian Sphaerocionium species, Hymenophyllum hirsutum (L.) Sw. and H. capillare are easily distinguished from each other: H. capillare usually has wingless stipes and rachis (except in dwarf forms exhibiting winged rachis, at least in their upper part) while H. hirsutum always bears a developed wing all along the stipes and rachis. In addition, lamina hairs are pedunculated in H. hirsutum (see Fig. 2A) and not pedunculated in H. capillare.
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 22, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Cathorops steindachneri
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Cathorops
Cathorops steindachneri

description: Cathorops steindachneri (Gilbert & Starks 1904). Steindachner’s Sea Catfish; Cuminate, Bagre, Congo Baboso
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from El Salvador to western Panama; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER, PN and Ni (Pacific); 0–5 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; DD (2017), population trend unknown. Literature: Robertson & Allen (2015: 4657; detailed description, including illustrations, and information on distribution, with a map, and ecology), Angulo (2021: 32; listed, including information on distribution) and Froese & Pauly (2023; listed, including information on identification, distribution and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 29, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Chaerilus tessellatus Qi, Zhu & Lourenco 2005
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Chaerilidae
Chaerilus
Chaerilus tessellatus

description: (6) Chaerilus tessellatus Qi, Zhu & Lourenço, 2005
TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Nyingchi City, Mêdog County, Drepung Township; MHBU (lost).
CHINESE EQUIVALENT. 格âṅfflx.
DISTRIBUTION (●). Xizang: Nyingchi City (Bayi District: Dongjiu Village and Sejila Mountain; Mêdog County: Drepung Township).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Highway plan; a Section of the master reference plan for Paterson
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1954

description: The objective of the Highway Plan is to formulate a comprehensive series of improvements and measures which will provide for a traffic flow which is not fixed but which is continually increasing. The Future Land Use Plan contemplates some shifts in population distribution but no substantial increase in total population. The three major objectives of a highway plan in Paterson are relief of congestion, reduction of accidents, and provision of facilities which will tend to conserve and encourage the expansion of the central business district. The Plan looks at the present highway traffic flow and expected future traffic, a future highway system, and suggests an improvement plan that consists of: first (or immediate) projects, intermediate projects and long range projects.
Notarius planiceps
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Notarius
Notarius planiceps

description: Notarius planiceps (Steindachner 1876). Thick-Lip Sea-Catfish; Cuminate, Cominata Chomba, Bagre Chombo
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from southern Baja California, Mexico, to Colombia; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN (Pacific); 0–7 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Villa (1982: 116, as Netuma planiceps —misspelled and synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Allen (2015: 571; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 30, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Rutherford master plan; Report number 3 master plan
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1966

description: This report summarizes in one document all of the pertinent information in the Master Plan contained in two previously issued reports. The first report covered historical background, earlier planning efforts, regional evaluation, population, housing and neighborhood analysis and the second covered physical characteristics, existing land use, community facilities, lot frontage analysis, economic base and fiscal studies. For a fuller discussion of these subjects, the reader should consult the first two complete reports. This document as well reviews the master plan, the land use plan, population forecast, communities facilities plan, circulation plan, capital improvements program, urban renewal and a continuing planning program.
STARD9 inhibitors for the treatment of cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A focal point of our research is to identify novel enzymatic activities that are critical for cancer cell division (cancer targets) and then discover/develop small molecules that can inhibit their activities (anticancer agents). Recently we identified STARD9 (Torres et al. Cell 2011), a novel mitotic kinesin required for cancer cell division/proliferation. Several of our findings indicate that inhibition of STARD9 function is a viable approach to treating cancer. First, depletion of STARD9 by siRNA leads to a mitotic arrest and an apoptotic cell death in many types of cancer cells, but has a limited effect on normal cells from the same tissues. Second, STARD9-depleted cells apoptose with faster kinetics than cells treated with inhibitors targeting other mitotic enzymes, which are being used in clinical trials. Third, STARD9 possesses an ATP hydrolyzing activity that is essential for its function and has been shown to be amenable to small molecule inhibition in other kinesins. Thus, we have developed an in vitro miniaturized high-throughput screening assay that will be used to identify inhibitors of STARD9. This assay is comprised of purified STARD9 motor domain, microtubules, ATP and enzymes that allow us to detect ATP hydrolysis with a plate reader. We propose to utilize this assay to screen through 140,000 drug-like molecules (housed at the UCLA Molecular Shared Screening Facility) for inhibitors of STARD9 ATPase activity. As an alternative we will employ structure-based computational virtual drug screening methodologies to identify STARD9 inhibitors. These inhibitors will be validated in vitro for their specificity for STARD9 and their efficacy will be analyzed in cell culture with a broad panel of cancer cell lines. This research is important because STARD9 inhibitors will enable us to study STARD9 function acutely in a temporal manner to define its role in cell division. Additionally, these inhibitors will be used as lead compounds for developing novel therapeutics for the treatment of cancer.
Additional file 1: Table S1. of Should the poor have no medicines to cure? A study on the association between social class and social security among the rural migrant workers in urban China
Creators: name: Guan, Ming
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Proposed updation of Kuppuswamy classification of socioeconomic status. (DOCX 17Â kb)
Controlled delivery of GM-CSF/IL-4 as an adjuvant for cancer immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Recent advances with anti-PD-1 and anti-CTLA-4 therapy have renewed interest in cancer immunotherapy. The delicate balance between tumor-associated immunosuppression and host anti-tumor defenses can be shifted when an appropriate stimulus is applied. In a phase II clinical trial we demonstrated that daily injections of human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) and Interleukin-4 (IL-4) for 7-14 days resulted in a dramatic expansion and functional activation of dendritic cells (DC) in-vivo within cancer patients. Therapy was associated with spontaneous tumor regression in some patients and correlative mouse studies confirmed the boost in antigen presenting cell number and functional vaccine responses. Although GM-CSF alone has some adjuvant effects in animals, GM-CSF cannot generate functional human DC. In this proposal we hypothesize that GM-CSF/IL-4 can be formulated into a slow-release hydrogel matrix so that a single injection can temporarily shift the balance of anti-tumor immunity toward therapeutic responses. Further, we believe that recent advances with humanized animal models will allow us to assess DC responses at both the regional and systemic level, setting the stage for future research. There are two aims. The first aim is to titrate the concentration and ratio of hydrogel structural components (thiolated hyaluronic acid; thiolated gelatin; and glutathione disulfide catalyzing reagent and/or polyethylene glycol diacrylate) and identify a formulation capable of optimal release of GM-CSF and IL-4 over a period of 4-10 days in-vitro. Cytokine release will be studied using a transwell assay system in which the concurrent differentiation of monocytes into DC can be studied. Second, titrating amounts of hydrogel-encapsulated GM-CSF/IL-4 will be assessed for their ability to promote regional (lymph node) and systemic (splenic, blood) expansion of activated human DC in humanized NOD/SCID-IL2r?- mice (hu-NSG model). NSG animals are reconstituted with CD34+ cord blood cells at birth and assessed once they develop a mature immune system. GM-CSF will be titrated to identify levels that expand regional and systemic myeloid responses. IL-4 will then be added and titrated to identify a combination that produces appropriate DC responses. Recent advances in hydrogel technology and the hu-NSG model provide a new opportunity to develop this adjuvant therapy. Positive findings would form the basis for ongoing research to study the interaction of this adjuvant with radiosurgery, tumor a
West Long Branch; the future community, master plan report six
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1964

description: This report is a recommended general guide for the comprehensive long-range development of the borough of West Long Branch,  Monmouth County, New Jersey.It contains a recommended Master Plan for the Borough, one of seven developed as part of the Community Planning Program being conducted by the Planning Board. The preceding five reports examine present-day conditions in West Long Branch. The seventh, and final, report contains an action program to implement the Plan. It provides a historical sketch, a summary of present conditions as well as the recommended master plan, objectives and proposals.
Comprehensive plan Borough of Audubon, Camden County, N.J.; Summary report
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1964

description: This document is a brief summary of the Comprehensive Plan for Audubon. The pamphlet  includes highlights of the more extensive presentation in Technical Reports #1 and #2 by the planning consultants. The primary concern addressed pertains to immediate and long-range measures which will safeguard he residential community. The recommendations include regulatory measures, a land-use plan, vehicular circulation improvements, and community facilities. The projections visualize Audubon's  needs to 1980.
Determining how a cancer/testis antigen inhibits circadian clock function to promote oncogenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Mammals have an internal molecular clock that coordinates physiology into rhythms that coincide with the external solar day, providing enhanced evolutionary fitness by timing the peak activity of integrated physiological processes. Loss of this internal 24-hour circadian clock leads to diabetes, metabolic syndrome, premature aging and cancer by disrupting the temporal coordination of physiology with our behavior and the external environment. Circadian disruption plays a key role in the etiology and progression of cancer, as loss of the clock removes intrinsic once-a-day limits to cellular proliferation and disconnects tumor cells from daily homeostatic metabolic inputs. Our long-term goal is to develop a deeper mechanistic understanding of how the molecular clock regulates cellular proliferation in order to develop new and innovative strategies to treat a broad spectrum of human cancers. The objective in this proposal is to identify the mechanism by which a cancer-induced protein represses the primary circadian transcription factor CLOCK:BMAL1 to disrupt clock function. As a cancer/testis antigen, the expression of PASD1 is restricted to germ line tissues such as the testis in healthy individuals, but is upregulated in a wide variety of human cancers. Our preliminary data provide evidence that PASD1 potently represses transcriptional activation by CLOCK:BMAL1 and dramatically attenuates circadian cycling in cell culture. Here we propose to use unbiased, genome-wide chromatin immunoprecipitation-sequencing approaches to identify how expression of PASD1 regulates genomic targeting of CLOCK:BMAL1 to control its activity. To investigate a potential mechanism of PASD1 action in human cancer, we will determine the effect of regulating PASD1 expression on circadian cycling in PASD1-positive human cancer cell lines. To do this, we will create bioluminescent clock reporter lines from colon and breast cancer cells that express PASD1 and determine the effect that targeted silencing of PASD1 has on quantitative parameters of the molecular oscillator. The proposed research is significant because it is expected to provide fundamentally new conceptual advances that address how CLOCK:BMAL1 works to generate 24-hour molecular rhythms and control global homeostasis. Ultimately, such knowledge has the potential to inform new strategies for basic and translational research into circadian control of human physiology as it applies to cancer.
Notarius troschelii
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Notarius
Notarius troschelii

description: Notarius troschelii (Gill 1863). Chili Sea-Catfish; Bagre Chili, Bagre Colorado
Vouchers: (other collections) TCWC 44401 (1). Distribution: Eastern Pacific Ocean; from Sinaloa, Mexico, to northern Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Ni (Pacific); 0–2 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Robertson & Allen (2015: 590; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 30, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Chaerilus tricostatus Pocock 1899
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Chaerilidae
Chaerilus
Chaerilus tricostatus

description: (7) Chaerilus tricostatus Pocock, 1899
TYPE LOCALITY AND TYPE DEPOSITORY. India, Assam State, Tinsukia District, Sadiya Town; NHMUK.
CHINESE EQUIVALENT. 三Pṅfflx.
DISTRIBUTION (○). Xizang: Nyingchi City (Mêdog and Zayü counties) and Shannan City (Tsona City); = “ Arunachal Pradesh: Upper Rottung in Siang District”.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
ATROF-MUHIT O'ZGARISHLARI VA YURAK-QON TOMIR KASALLIKLARI XAVFINING ORTISHI
Creators: name: Abdullaev, Nodirbek
Publisher: name: Zenodo
Year: 2025

description: So‘nggi yillarda atrof-muhitning tezkor o‘zgarishi inson salomatligiga, xususan, yurak-qon tomir tizimiga katta ta’sir ko‘rsatmoqda. Urbanizatsiya, sanoat rivojlanishi va iqlim o‘zgarishlari tufayli havo, suv va tuproqning ifloslanishi ortib bormoqda. Atmosfera havosidagi zararli moddalar, ekstremal haroratlar va toksik kimyoviy moddalar yurak-qon tomir tizimi kasalliklari xavfini oshiruvchi asosiy omillar sifatida e’tirof etilmoqda. Jahon sog‘liqni saqlash tashkiloti (JSST) ma’lumotlariga ko‘ra, yurak-qon tomir kasalliklari global o‘lim sabablari orasida yetakchi o‘rinni egallaydi.
Tetramorium placidum Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium placidum

description: Tetramorium placidum sp. n.
(Fig. 46)
Holotype worker. TL 3.4, HL 0.76, HW 0.69, CI 91, SL 0.56, SI 81, PW 0.54, AL 0.92.
Mandibles coarsely longitudinally striate; anterior clypeal margin without a median impression. Frontal carinae feebly sinuate, strongly developed through most of their length but becoming weaker close to the occiput, scarcely more strongly developed than the remaining cephalic rugular sculpture. Antennal scrobes weak. Eyes of moderate size, maximum diameter 0.15, about 0.22 x HW, situated at the midlength of the sides of the head. Propodeal spines short and stout, basally broad but tapering to an acute and slightly upcurved apex. Metapleural lobes long and very narrowly triangular, about 0.75 x the length of the propodeal spines. Outline shape of alitrunk and pedicel as in Fig. 46. Dorsum of head finely reticulaterugulose from level of anterior margin of eye to occiput, the reticular cross-meshes only slightly weaker than the longitudinal components. Dorsal alitrunk reticulate-rugose. Ground sculpture of both head and dorsal alitrunk a feeble punctulation, effaced in places, especially between the alitrunkal reticulations. Dorsum of petiole irregularly rugulose, dorsum of postpetiole unsculptured, smooth and polished. First gastral tergite unsculptured except for pits from which hairs arise. Standing fine pilosity abundant on all dorsal surfaces but the leading edges of the antennal scapes and the dorsal (outer) surfaces of the hind tibiae only with short, fine hairs which are subdecumbent to decumbent. Colour reddish brown.
Paratype workers. As holotype, with range of dimensions TL 3.3 - 3.4, HL 0.76 - 0.78. HW 0.69 - 0.72, CI 91 - 92, SL 0.56 - 0.58, SI 80 - 84, PW 0.52 - 0.54, AL 0.90 - 0.92 (2 measured).
Holotype worker, Mexico: Jalisco, Puerto Los Mazos, 10 miles SW. Autlan 4400 ft, 25. ix. 1973, leaf litter forest floor (A. Newton) (MCZ, Cambridge).
Paratypes. 2 workers with same data as holotype (BMNH; LACM, Los Angeles).
Apart from the type-series a short series in alcohol is present in CAS, San Francisco (determined as spinosum). These fit the above description but are lighter in colour (orange-yellow) and somewhat smaller than the types, HL 0.70 - 0.72, HW 0.66 - 0.68, CI 94, SL 0.50 - 0.52, SI 76, PW 0.50 - 0.52, AL 0.86 - 0.88 (3 measured). They come from Mexico: Nayarit, San Blas, 17. ix. 1953 (B. Malkin). This species is distinguished by its small size and unsculptured postpetiole.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 162-163