cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Strong and tough double network hydrogels based on poly(2-oxazoline) and polyacrylates
Creators: name: Benitez-Duif, Paola Andrea
Publisher: name: TU Dortmund
Year: 2025
Subjects: subject: Double network hydrogels
subject: Poly(2-oxazoline)
subject: Polyacrylates
subject: 660
subject: Hydrogel

description: Double network hydrogels (DNHs) are known for their exceptional stiffness, toughness, and tunable characteristics, making them valuable for applications in membrane technology, energy storage, and, of significant importance, in biomedicine. These materials show great potential for replicating complex biomaterials such as cartilage. This work presents, for the first time, the development of DNHs based on poly(2-oxazoline) as the primary network and various polyacrylates as the secondary network, resulting in materials with remarkable toughness. The thesis is structured into three main parts, each addressing different features and challenges involved in developing these DNHs. The first section focuses on the synthesis and optimization of DNHs using poly(2-oxazoline)s (POx) and poly(acrylic acid) (PAA), yielding materials with biomechanical properties comparable to cartilage, including high compressive strength and durability under physiological conditions. The second section further explores the potential of POx-based DNHs by incorporating various polyacrylates as secondary networks. This part emphasizes the investigation of interactions, functional groups, and the structural influence of the networks involved on the mechanical performance of the resulting hydrogels, achieving superior mechanical properties compared to conventional DNHs composed solely of polyacrylate networks. Additionally, the thesis addresses the critical challenge of maintaining hydrogel functionality across a wide pH range, essential for implantable materials exposed to varying tissue environments and inflammatory responses. A novel DNH formulation, comprising poly(2-methyl-2-oxazoline) and poly(acrylic acid-co-acrylamide) P(AA-co-AAm), is developed, demonstrating remarkable stability and mechanical integrity across pH levels from 3.4 to 10.5. Through extensive mechanical testing, this research highlights the robustness and versatility of these advanced DNHs, positioning them as strong candidates for use in tissue regeneration, implants, and other biomedical applications where durability and adaptability are crucial. This work contributes significantly to the understanding and application of DNHs in complex physiological environments.
Evaluation of the Support Provided to Male BRCA1/2 Mutation Carriers: Are Their Needs Being Met or Can Genetic Counselors Do Better?
Creators: name: Nassar, Anna-Lena
Publisher: name: Brandeis University
Year: 2018
Subjects: Support
Needs
Men
HBOC
BRCA
Male Carriers
Resources
Children
Fathers
Genetic Counseling
Mutation

description: Inherited mutations in the BRCA1 and BRCA2 genes are associated with hereditary breast and ovarian cancer syndrome (HBOC), a cancer susceptibility condition which significantly increases a woman’s risk for breast and ovarian cancer compared to the general population. Hence, HBOC is primarily associated with women while male carriers of a BRCA1 or BRCA2 mutation have a significantly increased risk for a variety of cancers as well. Research and efforts to support individuals affected with HBOC have been heavily focused on women, and little acknowledgment is given to the cancer risks and needs of male carriers. The purpose of this study was to get a better understanding of what resources and supports genetic counselors should offer to male BRCA mutation carriers, who are also fathers, to best serve their needs. Seven men who are a BRCA1 or BRCA2 mutation carrier and have biological children were recruited from an online support group and an online foundation to participate in a semi-structured phone interview. The major topics addressed included what was provided by the genetic counselor, what their experience was with supports and resources, their concerns, and how fatherhood impacted their experience with being a carrier. Thematic analysis of the interview transcripts was performed in ATLAS.ti (v.8) and seven themes were identified: (1) an overall positive impression of the genetic counseling session; interest in (2) more medical management options, (3) informational resources, and (4) support groups and opportunities to connect with others; (5) a need for recognition and awareness of male BRCA mutation carriers, (6) concern for children, and (7) normalization. This study showed that male BRCA mutation carriers have similar needs for informational and emotional supports and resources as women affected with HBOC.
Effects of -NO2 and -NH2 functional groups in mixed-linker Zr-based MOFs on gas adsorption of CO2 and CH4
Creators: name: Rada, Zana Hassan
name: Abid, Hussein Rasool
name: Sun, Hongqi
name: Shang, Jin
name: Li, Jiaye
name: He, Yingdian
name: Liu, Shaomin
name: Wang, Shaobin
Publisher: name: Swinburne
Year: 2024

description: This study was undertaken to evaluate the effects of mixing BDC-NO2 and BDC-NH2 linkers in the synthesis of Zr-based metal organic frameworks (Zr-MOFs) on their adsorption and separation of CO2 and CH4. UiO-66 with single or binary -NO2 and -NH2 samples were synthesized under solvothermal conditions and activated by solvent exchanging using methanol. Structural analyses of the materials were conducted using FTIR, XRD, TGA, SEM, 1HNMR and N2 adsorption/desorption techniques and adsorption of CO2 and CH4 at high pressures and different temperatures (273 and 298 K) was investigated. It was found that UiO-66-NH2 exhibited higher CO2 and CH4 adsorption capacities than those of UiO-66-NO2. Addition of -NH2 functional group in UiO-66-NO2 could enhance CO2 and CH4 adsorption due to the extra CO2 adsorption sites of -NH2 functional groups. Addition of -NO2 functional group to UiO-66-NH2 at a low loading could also increase CO2 and CH4 adsorption, however, a high loading of NO2 functional group to UiO-66-NH2 would result in decreased adsorption.
Development of laser techniques for applications in biomolecules and cellular systems.
Creators: name: Berinstain, Alain.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Chemistry, Organic.

description: The work presented in this thesis demonstrates how laser flash photolysis techniques can be employed in the application of the study of biomolecules and in cellular environments. The development of a new laser flash photolysis system is described, and a user-oriented, integrated hardware and software solution is presented. The combination of hardware and software used in this approach makes use of the concept of virtual instrumentation through the LabVIEW programming environment. This graphical approach to programming is optimized for data acquisition and instrument control, and for creating a user-friendly environment for the experimenter. Laser techniques have been used to study the biomolecule lignin and some of its model compounds in order to address the issue of light-induced colour reversion of pulp and paper products. High-yield pulps which contain lignin could have new and different industrial uses if the colour could be stabilized. Our work in this field has helped to elucidate the mechanism of yellowing of lignin mainly through the use of lignin model compounds such as $\alpha$-guaiacoxyacetoveratrone ($\alpha$-GAV) and related compounds. Our studies show that the formation of radicals from the excited singlet state is much more important than what is expected from aromatic ketones, and under certain conditions, the singlet pathway is the only degradative one. The results obtained in studies of crystalline $\alpha$-GAV show that efficient excited state deactivation pathways can be created by intermolecular interactions, leading to very good photostability of the molecule. Excited state transients detectable in solution are not present in the crystalline form. In contrast, $\alpha$-(p-methoxyphenoxy)-p-methoxy acetophenone (VII), does produce triplet state absorption on sufficiently long time scale to be detected. This difference is attributed to a different packing structure of crystalline VII which does not allow for efficient excited state deactivation as in the case of $\alpha$-GAV. Pulse radiolysis studies were carried out on VII, giving us insight into the fragmentation of the ketyl radical derived from this molecule. These results demonstrate that this ketyl radical is extremely short-lived and any strategy involving trapping of these types of radicals in the paper environment will most probably prove to be unsuccessful. The properties of the p-methoxyphenacyl radical (IX) were studied and show some interesting aspects of reactivity (acting as a carbon-centred radical), whereas the spectroscopic properties show a long-wavelength absorption which shows some oxygen-centred radical characteristics. These are supported by molecular modeling calculations. This thesis presents the first use of diffuse reflectance laser flash photolysis to directly monitor photochemically generated transients in living cell suspensions. (Abstract shortened by UMI.)
Vasilij Kamenskij et F. T. Marinetti : une poésie virtuelle.
Creators: name: Roger, Christine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Language, Modern.

description: Cette these porte sur le futurisme, un mouvement artistique avant-gardiste qui s'est eclos surtout en Italie et en Russie au debut du 20$\sp{\rm e}$ siecle. Ce mouvement a ete influence par le neo-impressionnisme et le cubisme danse le domaine de la peinture, tandis que dans celui de la poesie, il a remplace le symbolisme. Ulterieurement, le futurisme a influence le dadaisme. Plus precisement, cette these presente deux poetes dont les oeuvres ont subi les influences a la fois de la peinture et de la poesie. Les oeuvres sur lesquelles cette these se penche ont ete choisies pour tenir compte des deux branches importantes du futurisme, l'italienne et la russe, ainsi que de l'interpenetration entre la peinture et la poesie. Ces oeuvres sont les poemes IIBopeu C. N. IIIyKUH (Palais S. I. Scukin) et FaHR (Bain Russe) de Vasilij Kamenskij, ainsi que Apres la Marne, Joffre visita le front en auto et Le soir, couchee dans son lit, Elle relisait la lettre de son artilleur au front de F. T. Marinetti. Cependant, le poids de la recherche repose sur le poete russe etant donne que cette these se devoue a la litterature russe.
Convergent Evolution in Cryptosporidium parvum Lactate Dehydrogenase and SARS-CoV-2
Creators: name: Phuong, Karen
Publisher: name: Brandeis University
Year: 2022
Subjects: LDH
SARS-CoV-2
Evolution & development
Evolution
Phylogenetics

description: Convergent evolution is the process by which distantly related organisms independently evolve the similar traits. To understand the impact of convergence on protein structure, function, and mechanism, we studied the Cryptosporidium parvum lactate dehydrogenase (CpLDH). CpLDH evolved independently from all other lactate dehydrogenases (LDHs) in nature and has a unique protein structure. While all known LDHs follow the same enzymatic mechanism, we investigated if CpLDH follows a different mechanism due to its convergent evolution. Using steady state kinetic assays, we determined that CpLDH has a novel random bi-bi mechanism and is the only LDH known to do so. Furthermore, we studied the role of convergence in molecular phylogenetics and to elucidate the origins of SARS-CoV-2. Due to the redundancy of the genetic code or codon degeneracy, different codons can converge to the same amino acid. Previous work studying the amino acid sequences of SARS-CoV-2 suggested it was a recombinant virus from pangolins and bats. However, we surmised that amino acid convergence may have influenced this result. To investigate the origins of SARS-CoV-2, we generated maximum likelihood phylogenies on the codon level to eliminate the effects of codon degeneracy. Our codon sequence phylogenies indicated that SARS-CoV-2 originated from bats and is not a recombinant virus.
Converting 3D rigid metal–organic frameworks (MOFs) to 2D flexible networks via ligand exchange for enhanced CO2/N2 and CH4/N2 separation
Creators: name: He, Yingdian
name: Shang, Jin
name: Gu, Qinfen
name: Li, Gang
name: Li, Jiaye
name: Singh, Ranjeet
name: Xiao, Penny
name: Webley, Paul A.
Publisher: name: Swinburne
Year: 2024

description: We report a synthetic strategy for constructing a novel flexible MOF from a rigid parent structure by ligand exchange. This is the first reported study on introducing flexible heterogeneity into a rigid structure via substantial structural rearrangement. The daughter material exhibits enhanced gas separation selectivity compared with the parent.
Divided Labors: Narrative Innovation and Political Economy in Industrial Britain
Creators: name: Eggebrecht, Paige Marie
Publisher: name: Brandeis University
Year: 2021
Subjects: Charlotte Bronte
division of labor
George Dodd
industrialism
Jane Marcet
narrative
British & Irish Literature
British History

description: Divided Labors examines how literary narratives articulate and model division of labor, which was a core organizing principle of the social body, industrial economy, and knowledge
description: production in the first half of the nineteenth century in industrial Britain. Investigating the way that narrative simultaneously articulates and embodies division of labor and other political economic ideas, this dissertation examines the narrative innovations made by Conversations on Political Economy (1816) by Jane Marcet, the “Days at the Factories” (1841-1844) tours by George Dodd, and the social novel, Shirley (1849) by Charlotte Brontë. Division of labor, through its logics of organization, helps give comprehensibility to the vast and complex industrial economy and populous social body. It does this by distilling interconnected networks of productive relationships between laborers, machines, tools, factories, industries, and classes down to two related activities: dividing and combining. The organizational logics of the division of labor were, I argue, adapted into literary forms that serve both narrative and economic purposes; as a result, it also is an iterative vehicle by which economic knowledge is created, and ideologies are constructed and naturalized.
Metals recovery from industrial wastewaters and metallic hydroxide sludges through microbial sulphate-reduction.
Creators: name: Weyland, H. J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1977
Subjects: subject: Engineering, Civil.

description: This paper describes how metals originate in industrial wastewaters from the mining and metal finishing industries. Treatment of wastewaters containing dissolved metals produces a metallic hydroxide sludge which has to be disposed of in an environmentally acceptable way. It is estimated that the metal finishing industry annually disposes of 2,500,000 pounds and 49,000,000 pounds of non-ferrous metals in Canada and the United States respectively. These non-ferrous metals are either discharged to municipal sewers as untreated wastewater where they can interfere with the sewage treatment process and can also pose serious problems for sewage sludge disposal, or they can be disposed of as metallic hydroxide sludges in landfills, deepwells, or holding lagoons. The value of the metals contained in these sludges has long been recognized, and technology has been developed for their recovery. This recovery technology is based on well known chemical unit processes such as leaching, selective precipitation, ion exchange, and electrowinning. These processes are capable of recovering metals in a pure form, however, this technology does not appear to be economical at this time due to high energy costs, high chemical cost, and undue competition of this pure product from virgin metals. The paper describes a process whereby these non-ferrous metals can be recovered via microbial sulphate-reduction as metallic sulphides suitable as basemetal smelter feed. The bacterium Desulfovibrio desulfuricans is capable of reducing sulphate sulphur to sulphide sulphur while simultaneously oxidizing organic carbon to carbon dioxide. The hydrogen sulphide thus produced reacts with metal hydroxide sludge leachate to produce a high grade metallic sulphide concentrate suitable for basemetal smelter feed. The process described utilizes three industrial waste streams, namely: metallic hydroxide sludge, waste sulphuric acid, and biodegradable waste organics, as feedstocks for the reaction. Bench scale experiments are described which produced concentrates containing in excess of 28 per cent copper and zinc as sulphides. The paper includes a flow sheet and process design for a pilot plant recovering 1000 pounds per year of non-ferrous metal as metallic sulphides.
Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy
Creators: name: Moyle, Louise A.
name: Blanc, Eric
name: Jaka, Oihane
name: Prueller, Johanna
name: Banerji, Christopher R. S.
name: Tedesco, Francesco Saverio
name: Harridge, Stephen D. R.
name: Knight, Robert D.
name: Zammit, Peter S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Facioscapulohumeral muscular dystrophy (FSHD) involves sporadic expression of DUX4, which inhibits myogenesis and is pro-apoptotic. To identify target genes, we over-expressed DUX4 in myoblasts and found that the receptor tyrosine kinase Ret was significantly up-regulated, suggesting a role in FSHD. RET is dynamically expressed during myogenic progression in mouse and human myoblasts. Constitutive expression of either RET9 or RET51 increased myoblast proliferation, whereas siRNA-mediated knockdown of Ret induced myogenic differentiation. Suppressing RET activity using Sunitinib, a clinically- approved tyrosine kinase inhibitor, rescued differentiation in both DUX4-expressing murine myoblasts and in FSHD patient-derived myoblasts. Importantly, Sunitinib also increased engraftment and differentiation of FSHD myoblasts in regenerating mouse muscle. Thus, DUX4-mediated activation of Ret prevents myogenic differentiation and could contribute to FSHD pathology by preventing satellite cell-mediated repair. Rescue of DUX4-induced pathology by Sunitinib highlights the therapeutic potential of tyrosine kinase inhibitors for treatment of FSHD.
La théorie de la participation chez Charles Taylor: Formulation et application
Creators: name: Marleau Ouellet, Samuel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Political Science, General.

description: Cette thèse offre une interprétation et une application de la pensée politique de Charles Taylor sous l'angle de la participation politique. Plus précisement, elle émet au départ deux hypothèses. La première hypothèse est que la participation politique est un élément central de la pensée politique de Taylor. La seconde hypothèse est que le document de consultation du gouvernement québécois sur la réforme de la démocratie--- Le pouvoir aux citoyens et aux citoyennes (2002)---ne véhicule pas une conception de la démocratie compatible avec la conception taylorienne de la participation. La vérification de ces hypothèses procède en quatre temps. Les trois premiers chapitres sont consacrés à la première hypothèse. Le premier chapitre souligne ce qui distingue l'interprétation de l'oeuvre de Taylor proposée dans cette thèse en la situant brièvement par rapport à quelques-unes des principales interprétations déjà existantes. Le deuxième chapitre examine le chantier de l'analyse taylorienne de la modernité qui fonde la réflexion de Taylor sur la participation politique, ainsi que son parcours politique plus engagé et ses prises de position politiques les plus importantes. Le troisième chapitre présente les piliers qui constituent la théorie taylorienne de la participation politique. Enfin, le quatrième chapitre est consacré à la vérification de la seconde hypothèse. La perspective taylorienne est mise à contribution lors de l'évaluation normative du document de consultation Le pouvoir aux citoyens et aux citoyennes, qui s'avère limité à une perspective institutionnelle.
title: Transient Hypothyroidism
title: Dual Effect on Adult-Type Leydig Cell and Sertoli Cell Development
titleType: Subtitle
Creators: name: Rijntjes, Eddy
name: Gomes, Marcos L. M.
name: Zupanic, Nina
name: Swarts, Hans J. M.
name: Keijer, Jaap
name: Teerds, Katja J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: macroorchidism
subject: thyroid hormone
subject: proliferation
subject: testosterone
subject: testis
subject: Leydig cell
subject: Sertoli cell
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Transient neonatal 6-propyl-2-thiouracil (PTU) induced hypothyroidism affects Leydig and Sertoli cell numbers in the developing testis, resulting in increased adult testis size. The hypothyroid condition was thought to be responsible, an assumption questioned by studies showing that uninterrupted fetal/postnatal hypothyroidism did not affect adult testis size. Here, we investigated effects of transient hypothyroidism on Leydig and Sertoli cell development, employing a perinatal iodide-deficient diet in combination with sodium perchlorate. This hypothyroidism inducing diet was continued until days 1, 7, 14, or 28 postpartum (pp) respectively, when the rats were switched to a euthyroid diet and followed up to adulthood. Continuous euthyroid and hypothyroid, and neonatal PTU-treated rats switched to the euthyroid diet at 28 days pp, were included for comparison. No effects on formation of the adult-type Leydig cell population or on Sertoli cell proliferation and differentiation were observed when the diet switched at/or before day 14 pp. However, when the diet was discontinued at day 28 pp, Leydig cell development was delayed similarly to what was observed in chronic hypothyroid rats. Surprisingly, Sertoli cell proliferation was 6- to 8-fold increased 2 days after the diet switch and remained elevated the next days. In adulthood, Sertoli cell number per seminiferous tubule cross-section and consequently testis weight was increased in this group. These observations implicate that increased adult testis size in transiently hypothyroid rats is not caused by the hypothyroid condition per se, but originates from augmented Sertoli cell proliferation as a consequence of rapid normalization of thyroid hormone concentrations.
The quantification of L-dopa induced dyskinesia in Parkinson's disease patients
Creators: name: Lefebvre, Marie Julie Christine
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Health Sciences, Recreation.
subject: Biology, Physiology.

description: Parkinson's disease (PD) patients experience postural instability as a primary motor symptom (Parkinson, 1817). The majority of PD patients use L-dopa to treat motor symptoms associated with the disease; however, extended use of L-dopa can cause involuntary movement production termed L-dopa induced dyskinesia (LID) (Bezard et al., 2001). Recently, researchers have speculated that postural sway variability (CoP variability) is associated with clinically unapparent LID (Rocchi et al., 2004). This experiment sought to determine the relationship between CoP variability and LID in PD patients. Eight PD patients on L-dopa medication and eight age matched neurologically healthy control subjects performed a precision aiming task where we manipulated the orientation, size and distance of the target. We recorded CoP fluctuations using two force plates and kinematics of the head, torso, arm and leg segments using the VICON 3-D motion capture system. The results indicate that decreased joint coordination of the head, arm and torso segments contribute to greater CoP variability in PD patients, particularly in the ML direction. Our results also reveal that increased task difficulty by manipulation of target distance increases movement amplitude, and consequently CoP variability. These findings suggest a causal relationship between LID and CoP variability in PD patients.
Chansons infinies, suivi de, La valeur littéraire de la chanson
Creators: name: Bernier, Christian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Literature, Modern.
subject: Music.

description: Cette thèse en création littéraire regroupe, dans la première partie, 24 textes de chanson qui s'inscrivent dans un processus à mi-chemin entre l'autotelisme textuel et les contraintes propres au genre, surtout le rythme et la rime. Ainsi, si certains textes entrent dans la grande tradition de la chanson française, ou vers symétriques, rimes, couplets et refrains sont de mise, d'autres rompent avec cette tradition. C'est dans cette même veine exploratoire que je questionne la longueur généralement présumée des textes de chanson et que je tente de mettre à profit tous les niveaux de langue. La partie réflexive a comme appui théorique de base la proposition de Denis Saint-Jacques selon laquelle l'inscription du littéraire dans un texte se fait par la redondance de formes types propres à chaque genre, de l'interdiscursivité et de l'autoreprésentation thématique. Cette inscription passé par divers procédés tels que la métaphore et l'exploitation de lieux communs. L'analyse de mes textes tend à démontrer que les procédés d'écriture les plus communs à la chanson, et peut-être les plus importants, sont les divers types de répétition. En effet, le rythme et la musicalité se forment par la reprise, ce qui implique qu'une prosodie est possible sans avoir recours à la versification traditionnelle. Il ressort de ma thèse que les textes de chanson entretiennent toujours des liens étroits avec la poésie. Enfin, ce regard porte sur mes textes éclaire les voies que je pourrai désormais emprunter dans mon processus de création.
Guns, Gangsters, and the New Deal: The Politics of Firearm Regulation and the First Federal Gun Control Act
Creators: name: Hall, Robert Maximilian
Publisher: name: Brandeis University
Year: 2024
Subjects: New Deal
Gun Control
Gangsters
1920s
1930s
National Firearms Act of 1934
Prohibition

description: This Thesis begins by discussing the current status of Second Amendment jurisprudence in the Supreme Court, followed by a brief history of fundamental shifts in American legal philosophy following the Civil War and the Reconstruction Amendments that ultimately altered Americans' understanding of Federalism and the role of the national government. These legal developments, along with 19th-century and early 20th-century firearms laws, laid the foundation for the federal government to enact national legislation. The Thesis then explores a brief history of the Prohibition era, organized crime syndicates, and the growing crisis of violence that the American public faced. Next, the Thesis looks at the Roosevelt Administration’s response and how the federal government supported the first federal gun control bill, The National Firearms Act of 1934, along with other New Deal-era crime measures. Finally, the Thesis analyzes the passing of the legislation, its legacy, and legal challenges. Together, this presents a more complete narrative of how the politics of gun control were tied directly to the New Deal and Progressive ideology, how the first National Firearms Act was a successful measure aimed at addressing rising crime and extremely dangerous weapons, and how the NRA and other Pro-gun interests were working for the public good and not the legislative saboteurs they appear to be today.  
Réflexions traductologiques autour de la place du texte traduit dans le cadre des traités multilingues: l'ALENA, un cas d'espèce
Creators: name: Cordoba Serrano, Maria Sierra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Language, General.

description: Based on the positivist ideal that the original text as immutable (Kasirer, 2001: 339), a series of negative connotations has been attributed to translation as a product in the legal community. In addition, the discipline of Translation Studies has devoted little attention to the status of the translated legal text. Faced with this marginalization, the goal of this thesis is to determine the importance of the hermeneutic role (Cote, 1999: 409) of authenticated translations in the interpretative process of multilingual treaties and, in a more general perspective, to show the status of authenticated translated texts. In fact, these texts, which often constitute legal precedents for subsequent agreements, can attain an equal, if not superior, position with respect to the so-called "original" text. First, this thesis presents an analysis of general rules of interpretation in order to determine the importance of consulting different authenticated translations of a multilingual treaty in the interpretative process. Second, the historical evolution of the role of the translated text in the interpretative process will be outlined. The goal here is to determine whether any changes have taken place that improved the status of translation in this interpretative context. Finally, in an attempt to be objective, a quantitative analysis shows the limitations of the hermeneutic role played by translations in the context of disputes settled pursuant to chapter 11 of the North American Free Trade Agreement.
Cell Type-Specific Signaling During Gustatory Learning Within Basolateral Amygdala Projection Neurons
Creators: name: Xiong, Joanna
Publisher: name: Brandeis University
Year: 2023
Subjects: Conditioned Taste Aversion
Associative Learning
Basolateral Amygdala
Nucleus Accumbens
Ventral Striatum
Learning and Memory
Stk11
Fos
Gustatory Learning
3D Image Analysis
RNAscope
RNA in situ hybridization
Colocalization Analysis

description: Associative learning is driven by survival incentives that naturally dispose animals towards risk avoidance and reward seeking in the natural world. In the case of conditioned taste aversion (CTA), animals learn to avoid a palatable taste stimulus after associating it with gastric malaise. In a previous study, an activity-dependent immediate early gene, Fos, and a gene encoding the master kinase for metabolic control, serine/threonine kinase 11 (Stk11), were identified as key regulators for long-term memory formation. Deletion of either Fos or Stk11 in basolateral amygdala projection neurons (BLApn) prevent CTA acquisition yet increase neuronal intrinsic excitability, and the mechanistic connection between enhanced intrinsic excitability and learning impairment is unclear. Recent studies show that the anterior BLA consists of functionally divergent subpopulations of projection neurons that drive motivationally opposing behaviors. In order to further understand the subtype-specific molecular mechanisms of learning and motivation, we used a multiplex labeling system to investigate whether CTA would induce differential transcriptional changes of Fos and Stk11 in different BLApn subpopulations. Results show that Fos mRNA fold change significantly increases in negative valence subpopulations and significantly decreases in positive valence subpopulations after CTA training. On the other hand, expression of Stk11 and Mark2 underwent a global reduction across subpopulations after CTA training. Overall, these findings suggest that cell type-specific expression of Fos and experience-dependent expression of Stk11 takes place during CTA acquisition. These results suggest that Fos and Stk11 pathways are likely activated by different components of gustatory learning, and the means by which both pathways independently regulate learning and memory is yet to be determined.
Our Land and the Land of Our Fathers: The Case of Aaron David Gordon
Creators: name: Dahlen, Yonatan
Publisher: name: Brandeis University
Year: 2011
Subjects: aliyah
pioneer
a.d. gordon
aaron david gordon
halutz
Israel

description: The following study confronts a current wave of Israeli historiography seeking to separate myth from reality in halutz ethos during the second and third aliyot. While leading historians argue for a political and social desacralization of this spiritually rich era, I insist on the legitimacy and sincerity of religious and mystical language ubiquitous in pioneer writing and practice. Using Aaron David Gordon as a paradigm of this movement, I propose an analysis of Israeli pioneer history free from metaphor, where the Land of Israel becomes the focal point of a newly interpreted religiosity.
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
Creators: name: Imamura, Hideo
name: Downing, Tim
name: Van Den Broeck, Frederik
name: Sanders, Mandy J.
name: Rijal, Suman
name: Sundar, Shyam
name: Mannaert, An
name: Vanaerschot, Manu
name: Berg, Maya
name: De Muylder, Geraldine
name: Dumetz, Franck
name: Cuypers, Bart
name: Maes, Ilse
name: Domagalska, Malgorzata
name: Decuypere, Saskia
name: Rai, Keshav
name: Uranw, Surendra
name: Bhattarai, Narayan Raj
name: Khanal, Basudha
name: Prajapati, Vijay Kumar
name: Sharma, Smriti
name: Stark, Oilvia
name: Schoenian, Gabriele
name: De Koning, Harry P.
name: Settimo, Luca
name: Vanhollebeke, Benoit
name: Roy, Syamal
name: Ostyn, Bart
name: Boelaert, Marleen
name: Maes, Louis
name: Berriman, Matthew
name: Dujardin, Jean-Claude
name: Cotton, James A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor in the persistence of this epidemic. Here we use whole genome sequences from 204 clinical isolates to track the evolution and epidemiology of L. donovani from the ISC. We identify independent radiations that have emerged since a bottleneck coincident with 1960s DDT spraying campaigns. A genetically distinct population frequently resistant to antimonials has a two base-pair insertion in the aquaglyceroporin gene LdAQP1 that prevents the transport of trivalent antimonials. We find evidence of genetic exchange between ISC populations, and show that the mutation in LdAQP1 has spread by recombination. Our results reveal the complexity of L. donovani evolution in the ISC in response to drug treatment.
Integrated Pest Management, 2020 Quarter 4 Newsletter
Creators: name: Washington State University Extension
Publisher: name: Washington State University
Year: 2020
Subjects: Pest Management

description: Highlights include:
description: Tree fruit outreach in pears and IPM of codling moth & stink bugs
description: Benefits of pruning in urban IPM
description: Focus on herbicide resistance in small grains
description: Watermelon grafting articles published
description: Onion grower survey shows high IPM adoption
description: IPM outreach at grape and mint conferences
description: New video explains phylloxera monitoring
The integration of patient cues, nursing knowledge and clinical judgements by Intensive Care Unit nurses in simulated situations of urgency.
Creators: name: Van Den Berg, Rick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Health Sciences, Nursing.

description: Nurses who work in critical care areas must learn how to make effective clinical judgements about patients under a variety of conditions. The process of making clinical judgements includes attending to cues from the patient and integrating prior nursing knowledge. The study examined this process within the context of simulated patient instability, in which there is minimal time for the nurse to reflect upon the judgements made. Registered Nurses from four Intensive Care Units (ICU) within the Regional Municipality of Ottawa-Carleton were randomly selected and invited to participate in the study and twenty-four nurses participated. The study employed a 'think aloud' method and verbal protocol analysis to examine the number and types of patient cues from six case studies, that were attended to by the nurses. The relationship between cue recognition, domain-specific knowledge and clinical judgements was examined. Nurses verbalized a low percentage of the available patient cues, knowledge, and clinical judgements. A significant and moderately positive correlation was found between cue recognition and knowledge verbalized, knowledge verbalized and clinical judgements made and cue recognition and clinical judgements made. The number of knowledge items verbalized were positively correlated with the level of ICU (tertiary or secondary), with higher levels of knowledge items verbalized found in the nurses working in the two tertiary level ICUs. The results of this study have implications for all nurses as well as those in advanced practice roles. Case reviews, as part of ongoing education, can encourage the nurses to examine and improve their clinical judgements. Teaching nurses to become reflective practitioners would provide them with tools to examine and improve their own process of making clinical judgements. Ensuring that nurses have current nursing knowledge can provide a stronger basis for their clinical judgements. Areas for further research are described.
Measuring and understanding child-to-parent abuse in Australia
Creators: name: Simmons, Melanie L. O.
Publisher: name: Swinburne
Year: 2024

description: This thesis developed a measure, the Abusive behaviour by Children- Indices (ABC-I), to assess the presence of abusive behaviours by children aged 14-25 years old towards their parents. Using the ABC-I, 1 in 6 youth (N = 435) were considered to be abusive towards their parents. The ABC-I is the first measure of its kind to include a cut-off differentiating normative from abusive behaviour according to social norms as defined by parents, which has significant implications for intervention. This thesis also provides novel insight into social norms regarding child-to-parent abuse and the risk factors associated with child-to-parent abuse in Australia.
Elasto-plastic finite element for pipelines.
Creators: name: Nowzartash, Farhood.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Engineering, Civil.

description: An efficient pipe element for the modeling of the inelastic behaviour of three-dimensional pipes is presented. The formulation is based on a two-node element with twelve degrees of freedom. The element consists of an elastic portion and two potentially plastic generalized 3D hinges located at both nodes. The formulation is based on a lumped plasticity approach. The behaviour of plastic hinges is characterized using recently developed interaction relations for pipe sections. The interaction relations are exact and include the effects of axial force, bi-axial bending moments, bi-axial shear, torsion and internal and/or external pressure. The element models shear deformation effects both in the elastic and plastic ranges. Therefore, it is suitable for predicting the behaviour of pipe segments subject to high shear forces. The analysis is implemented using the displacement control scheme in order to capture the peak point of the load deformation response without numerical difficulty. The normality condition concept in conjunction with the yield hyper-surface at stress resultant level is used to approximately simulate the material nonlinearity effects. The developed technique models material nonlinearity in a very efficient way when compared to full 3D or shell finite element analysis. The model is thus particularly suitable for long pipeline systems. Solutions for simple problems are provided and compared to several other well-established elements in the ABAQUS(TM) library in order to assess the validity of the results and demonstrate their scope of applicability. A discussion of additional features that can be added to the analysis is also presented.
Drebrin Regulates Neuroblast Migration in the Postnatal Mammalian Brain
Creators: name: Sonego, M.
name: Oberoi, M.
name: Stoddart, J.
name: Gajendra, S.
name: Hendricusdottir, R.
name: Oozeer, F.
name: Worth, D. C.
name: Hobbs, C.
name: Eickholt, B. J.
name: Gordon-Weeks, P. R.
name: Doherty, P.
name: Lalli, G.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: After birth, stem cells in the subventricular zone (SVZ) generate neuroblasts that migrate along the rostral migratory stream (RMS) to become interneurons in the olfactory bulb (OB). This migration is crucial for the proper integration of newborn neurons in a pre-existing synaptic network and is believed to play a key role in infant human brain development. Many regulators of neuroblast migration have been identified; however, still very little is known about the intracellular molecular mechanisms controlling this process. Here, we have investigated the function of drebrin, an actin-binding protein highly expressed in the RMS of the postnatal mammalian brain. Neuroblast migration was monitored both in culture and in brain slices obtained from electroporated mice by time-lapse spinning disk confocal microscopy. Depletion of drebrin using distinct RNAi approaches in early postnatal mice affects neuroblast morphology and impairs neuroblast migration and orientation in vitro and in vivo. Overexpression of drebrin also impairs migration along the RMS and affects the distribution of neuroblasts at their final destination, the OB. Drebrin phosphorylation on Ser142 by Cyclin-dependent kinase 5 (Cdk5) has been recently shown to regulate F-actin-microtubule coupling in neuronal growth cones. We also investigated the functional significance of this phosphorylation in RMS neuroblasts using in vivo postnatal electroporation of phosphomimetic (S142D) or non-phosphorylatable (S142A) drebrin in the SVZ of mouse pups. Preventing or mimicking phosphorylation of S142 in vivo caused similar effects on neuroblast dynamics, leading to aberrant neuroblast branching. We conclude that drebrin is necessary for efficient migration of SVZ-derived neuroblasts and propose that regulated phosphorylation of drebrin on S142 maintains leading process stability for polarized migration along the RMS, thus ensuring proper neurogenesis.
Customer understanding with the interactionist's lens: Exploring the experience of the Chinese Millennial Generation for banking service design
Creators: name: Li, Weidan
Publisher: name: Swinburne
Year: 2024

description: This thesis explores the Chinese Millennial Generation’s banking experience in their daily context. The research starts by bringing up the facts that Chinese Millennials are the growing cohort that is increasingly impact the world consuming marketing. The author collaborated with ANZ Banking Group to study one facet of the Chinese Millennials lives – the daily banking attitude and behaviour. By qualitative research, the author has found insightful results to lead to design principles for this market. The research methods also inform an overarching framework to plan and implement design research from a social interaction perspective.
Chinese Parents’ Perception of Autism Spectrum Disorders: An Exploration of the Influence of Culture
Creators: name: Chen, Jin Yun
Publisher: name: Brandeis University
Year: 2014
Subjects: cultural competency
parental perception
cultural beliefs
autism spectrum disorder
ASD
Chinese-American parents
Immigrants

description: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication skills, repetitive behaviors, and restricted interests. Numerous studies have examined the underlying causes of ASD and have identified biological causes including genetic and environmental factors. Researchers have also explored parental perceptions regarding the etiology of ASD. These studies have demonstrated that parents endorse a wide variety of causes for ASD, including genetic factors, vaccinations, prenatal exposures, and other environmental factors. However, there are few studies addressing parental perceptions among minority or immigrant populations, who may be likely to hold beliefs that are heavily influenced by their own culture. The purpose of this study was to explore the impact of culture on perceptions of causality, treatment and family dynamics among parents of children with ASD who are of Chinese ancestry. To this end, we conducted semi-structured interviews with six Chinese-American mothers of children with ASD and analyzed the interview transcripts using ATLAS.ti software. We found that as a group the experiences and beliefs of the mothers we interviewed were similar to those of parents described in previous studies. For example, the mothers we interviewed believed in Western notions of causality (including genetics) and treatment (such as ABA therapy), and shared stories of guilt, shame and blame in their families and social networks. However, our mothers also commented on experiences that were unique to their status as immigrants, such as additional grief over the loss of opportunity in the United States for their child, and further isolation caused by language barriers and geographical distance from extended family members. Our results suggest a need for additional support for Chinese immigrant parents coping with their child’s diagnosis of ASD. Future research should focus on exploring the experiences of a broader population of immigrant parents whose children have been diagnosed with ASD.
The Death of the Image: Liberation Beyond Reflection
Creators: name: Patrick Carodine
Publisher: name: Unified Theistic Naturalism
Year: 2025

description: There is no greater veil than the image one holds of oneself. Built not of flesh or ego, but of subtle self-perception, this image can wear the face of humility, truth, service—even enlightenment. It is crafted through suffering, praise, discipline, and the echoes of belonging. But it is still an image. And all images distort.

 

This paper reveals the path not to perfect the image, but to let it die. For in the death of the image, paradise is no longer chased—it is revealed.