cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CSF biomarkers of brain metastases from lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Brain metastases represent a major problem in patients with both non-small cell and small cell lung cancer histology. Relapse in the brain occurs in at least 25% of patients with surgically removed non-small cell lung cancer and 65% of patients with small cell lung cancer. Because of this natural propensity for central nervous system (CNS) dissemination, there has been increasing interest in the preventive use of radiation treatment of the brain (prophylactic cranial irradiation) in selected patients who have responded well to surgery, chemotherapy and radiation treatment of their primary tumors. This prophylactic cranial irradiation has been shown to significantly decrease the risk for CNS relapse in the brain, and it may result in the extension of survival. However, because of concerns regarding the toxicities associated with brain irradiation, routine use of this treatment is restricted.

 We propose to use state-of-the-art molecular analysis of the cerebrospinal fluid (CSF) in order to identify biomarkers of brain metastases from lung cancer. The identification of such biomarkers would have a significant impact in the treatment of patients with this malignancy. First, CSF biomarkers for lung cancer may help doctors decide which patients need prophylactic cranial irradiation. Second, CSF biomarkers for lung cancer brain metastases could help doctors determine whether a brain tumor is caused by metastatic lung cancer, whether the tumor began in the brain, or whether it metastasized from a different organ besides the lungs. Thus, some neurosurgical procedures might be avoided to reduce risks to patients. Third, CSF biomarkers help doctors evaluate the clinical response. If such biomarkers disappear after treatment, then the doctors would be confident that the tumor cells are absent. Finally, the identification of CSF biomarkers may also be relevant to more early stage lung cancer. Such biomarkers could be used to screen patients who are at risk for lung cancer, so that some patients may achieve early diagnosis and cure before they develop symptoms.

 We plan to search for informative and novel CSF markers using combined gene expression profiling and mass spectrometry proteomics approaches. Our preliminary work in gene profiling on lymphomas has yielded promising candidate markers, and we believe that a similar approach in lung cancer patients will provide evidence for “lead” CNS markers for more detailed validation. The proteomics work will be done with a biotech company, SurroMed, Inc. in Mountain View, CA. We hope that our project will lead to better clinical management of brain metastasis. Of the 150,000 new brain metastatic cancers diagnosed yearly, approximately 40,000 originate from lung cancers. This research topic represents an ideal application for the newly emerging gene profiling and proteomics technologies.
D-branes and orientifolds in calabi-yau compactifications
Creators: name: Garcia-Raboso, Alberto
Publisher: name: No Publisher Supplied
Year: 2008

description: We explore the dynamics of nonsupersymmetric D-brane configurations on Calabi-Yau orientifolds with fluxes. We show that supergravity D-terms capture supersymmetry breaking effects predicted by more abstract II-stability considerations. We also investigate the vacuum structure of such configurations in the presence of fluxes. Based on the shape of the potential, we argue that metastable nonsupersymmetric vacua can be in principle obtained by tuning the values of fluxes.We also develop computational tools for the tree-level superpotential of B-branes in Calabi- Yau orientifolds. Our method is based on a systematic implementation of the orientifold projection in the geometric approach of Aspinwall and Katz. In the process we lay down some ground rules for orientifold pro jections in the derived category.This dissertation is based on the following articles published in peer-reviewed journals: * D.-E. Diaconescu, A. Garcia-Raboso and K. Sinha, A D-brane landscape on Calabi-Yau manifolds, JHEP 0606, 058 (2006), hep-th/0602138. * D.-E. Diaconescu, A. Garcia-Raboso, R. L. Karp and K. Sinha, D-brane superpotentials in Calabi-Yau orientifolds, Adv. Theor. Math. Phys. 11, 471 (2007), hep-th/0606180.
Tympanoterpes cordubensis Berg 1884
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Tympanoterpes
Tympanoterpes cordubensis

description: Tympanoterpes cordubensis Berg, 1884
Tympanoterpes cordubensis Berg 1884: 113 (type material examined).
Type locality. Córdoba, Argentina.
Remarks. The species was reported from Córdoba Province (Berg 1884). We collected specimens in Córdoba and San Luis Provinces. The species is associated with the Monte floristic province (Sanborn et al. 2011a).
New provincial records. San Luis, ca. El Chorrillo, 22-I-1988, J.E. & M.S. Heath-Allen Sanborn-F. Noriega coll. (one male, MSHC, three males, AFSC); Prov. San Luis, San Luis, 6-I-1992, A. Sanborn & P. Ganter coll. (three males, AFSC).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 62, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Gymnodactylus longipes Nikolsky 1896
Creators: name: Ananjeva, Natalia B.
name: Milto, Konstantin D.
name: Barabanov, Andrei V.
name: Golynsky, Evgeny A.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Phyllodactylidae
Gymnodactylus
Gymnodactylus longipes

description: Gymnodactylus longipes NIKOLSKY (1896: 369)
Lectotype (designated by Szczerbak & Golubev 1986):
ZISP 8810.1, adult female, “Persia orient., Neh” [Nehbandan, South Khorasan Province, Iran, 31.54 N 60.04 E]. Leg: N. A. Zarudny, 1896.
Paralectotypes:
NMW 17392–17393, 2 specimens, “Nech, E-Persien” [Nehbandan, South Khorasan Province, Iran, 31.54 N 60.04 E]. Leg: N. A. Zarudny, 1896.
ZISP 8809.1 - 3, 3 specimens, “Persia orient., Neh” [Nehbandan, South Khorasan Province, Iran, 31.54 N 60.04 E]. Leg: N. A. Zarudny, 1896.
ZISP 8810.2 - 3, 2 specimens, “Persia orient., Neh” [Nehbandan, South Khorasan Province, Iran, 31.54 N 60.04 E]. Leg: N. A. Zarudny, 1896.
ZISP 8811, 1 specimen, “Persia orient., Neh” [Nehbandan, South Khorasan Province, Iran, 31.54 N 60.04 E]. Leg: N. A. Zarudny, 1896.
Present name: Tenuidactylus longipes (Nikolsky, 1896) fide Bauer et al. (2013).
Remarks: 3 paralectotypes (ZISP 8809.1-3) could not be located in the ZISP collection.
description: Published as part of Ananjeva, Natalia B., Milto, Konstantin D., Barabanov, Andrei V. & Golynsky, Evgeny A., 2020, An annotated type catalogue of amphibians and reptiles collected by Nikolay A Zarudny in Iran and Middle Asia, pp. 101-128 in Zootaxa 4722 (2) on pages 114-115, DOI: 10.11646/zootaxa.4722.2.1, http://zenodo.org/record/3605815
Visual art made musical: issues of shape, proportion and large-scale form in Escher sketches
Creators: name: Gage, Darren
Publisher: name: No Publisher Supplied
Year: 2008

description: This dissertation examines the relationship between the orchestral work, Escher Sketches, and the two graphic prints by M.C. Escher on which its music is based, Regular Division of the Plane I and Regular Division of the Plane VI.  Chapter 1 provides background information on the two visual works and, generally, on Escher's work with the "regular division of the plane."  Chapter 2 discusses how Escher Sketches, a 12-tone piece, utilizes a regular division of the octave in the construction of the prime row forms behind its two movements.  Chapter 3 and Chapter 4 explain how Movement I, "Birds and Fish," and Movement II, "Lizards," share structural similarities with Escher's prints at the background, middleground and foreground levels of the music.
Dietary fat and ETS effects on lung epithelial biology
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Exposure to the air pollutant, environmental tobacco smoke (ETS) is causally associated with lung cancer in both men and women. ETS is a complex mixture that contains over 4000 different chemicals, many of which are well-known human carcinogens and that also injure cells. Lung diseases have increased in prevalence in the latter half of the 20th century. This may be due to several factors in combination such as consumption of a diet high in saturated fat and exposure to the carcinogens and toxins in air pollutants. Lung cancer risk is increased by exposure to ETS. Lung cancer risk may also be increased by a high dietary intake of saturated fat. The most obvious impact of a high fat diet is weight gain. The National Institute of Diabetes, Digestive and Kidney diseases estimates that one-third of Americans, about 58 million people, are overweight. Weight gain has been shown to accelerate loss of lung function (the ability to breath) as people age. Little is known about the effects of a high fat diet on lung cells. Even less is known about how diet affects the lung’s ability to withstand toxins found in ETS. There are sex-based differences in how the lung responds to ETS. The risk for cancers of the peripheral lung is higher in women than in men exposed to tobacco smoke. Epidemiologic studies also suggest that women with altered expression of certain genes and enzymes have an increased risk of cancer. These genes and enzymes interact with tobacco smoke to cause formation of tumors as well as acute toxicity to epithelial cells in the lung. Our hypothesis is that a high fat diet will enhance the toxicity of ETS in the lung. We further hypothesize that these responses will differ by gender. We will try to define the mechanism for the enhanced toxicity. Our long term goal is to define the mechanisms by which an unhealthy lifestyle, such as consumption of a high fat diet, impairs the lung’s ability to resist injury by ETS and thus leads to lung diseases such as cancer, asthma and bronchitis. This research has potential impact for both men and women who smoke or are exposed to ETS and consume a diet high in saturated fat. We expect that these studies will benefit the general population by defining the mechanisms that make a high fat diet and ETS exposure both risk factors for loss of lung function and lung cancer. These studies are highly relevant to TRDRP research priorities regarding the effects of environmental tobacco smoke on human health.
title: Proceedings Bauphysiktage in Weimar 2019: Bauphysik in Forschung und Praxis
Creators: name: :None
Publisher: name: Bauhaus-Universität Weimar
Year: 2024
Subjects: subject: Bauphysik
subject: Weimar
subject: Akustik
subject: Raumklima
subject: Energie
subject: Behaglichkeit
subject: Weiterbildung
subject: 000
subject: 500
subject: 600
subject: 624
subject: 720

description: Wie kann die Energiebilanz von Gebäuden nachhaltig verbessert werden? Welchen Einfluss hat das Raumklima auf unser Wohlbefinden? Und gibt es dabei typische Verhaltensmuster in Bürogebäuden? Diese und weitere aktuelle Fragestellungen aus Forschung, Bauplanung und Ausführung stehen bei den Bauphysiktagen 2019 auf der Agenda. »Die Erfordernisse des Klimaschutzes sowie die fortschreitende Globalisierung und Digitalisierung der modernen Bauindustrie stellen hohe Anforderungen an die Bauphysik«, weiß Prof. Dr.-Ing. Conrad Völker von der Bauhaus-Universität Weimar. In über 50 Vorträgen sollen die hierfür notwendigen Verfahren und Berechnungsmethoden sowie Änderungen in der Normung dargelegt und Disziplinen übergreifend mit Ingenieuren und Architekten diskutiert werden. Das Themenspektrum der zweitägigen Konferenz reicht hierbei von innovativen Baustoffen, über personalisierte Klimaregulierung und moderne Brandschutzkonzepte bis hin zu Fortschritten in der Raum- und Bauakustik. Alle zwei Jahre finden die Bauphysiktage an wechselnden Orten statt. Im Bauhaus-Jubiläumsjahr wird die Fachtagung erstmals seit 2011 wieder in Weimar ausgerichtet. Mit einem Grußwort zum Thema »100 Jahre Bauhaus« wird das Programm von Prof. Dr. Winfried Speitkamp, Präsident der Bauhaus-Universität Weimar, am 25. September 2019 im Hörsaalgebäude eröffnet.
The role of soil metal contamination in the vegetative assemblage development of an urban brownfield
Creators: name: Gallagher, Francis J. (Frank J.)
Publisher: name: No Publisher Supplied
Year: 2008

description: Anthropogenic sources of toxic elements have seriously compromised the ecological integrity of many green areas in urban landscapes.  Analysis of soil samples from a brownfield within Liberty State Park, Jersey City, New Jersey, USA, shows that arsenic, chromium, lead, zinc and vanadium exist at concentrations above those considered ambient for the area.  Accumulation and translocation features were characterized for the dominant plant species of four vegetative assemblages.  A comparison of soil metal maps and vegetative assemblage maps indicates that northern hardwoods dominated areas of increasing total soil metal load while semi-emergent marshes, consisting mostly of endemic species were restricted primarily to areas of low soil metal load. Using both satellite imagery and field spectral measurement we examined plant productivity at the assemblage and individual specimen level.  In addition, we studied longer-term growth trends via tree core data (basal area increase). Leaf chlorophyll content within the hardwood assemblage correlated with a threshold model for metal tolerance, decreasing significantly beyond a total soil metal index of 3.5.  Biomass production in Betula populifolia (Marsh) (Gray Birch), the co-dominant tree species, demonstrated an inverse relationship with the concentration of Zn in the leaf tissue during the growing season.  Incremental basal area growth in B. populifolia also exhibited a reciprocal relationship with soil metal load.The results of this study also indicate that B. populifolia, employs a strategy whereby different wing loading rates result from variation in size and weight of the seed.  The decrease in seed size correlated well with total soil metal load, while the correlation with seed weight was marginal.  All three areas of the study indicate that assemblage development is impacted if not driven by soil metal contamination. Hence, models for vegetative assembly development, at least those associated with contamination gradients within the urban context, should account for these abiotic factors rather than focusing primarily on competition or facilitation between species.
title: Proceedings Weimarer Bauphysiktagung 2011: Bauphysik in Forschung und Praxis
Creators: name: :None
Publisher: name: Verlag der Bauhaus-Universität Weimar
Year: 2011
Subjects: subject: Bauphysik
subject: Weimar
subject: Akustik
subject: Raumklima
subject: Energie
subject: Behaglichkeit
subject: Weiterbildung
subject: 000
subject: 500
subject: 600
subject: 624
subject: 720

description: Auf der Weimarer Bauphysiktagung werden Themen aus der aktuellen Forschung und moderneAnwendungen in der Praxis vorgestellt. Sie ist damit ein ideales Diskussionsforum zum gegenseitigen Austausch von Fachleuten aus Wissenschaft und Praxis. Maßnahmen zur Verbesserung der Energiebilanz eines Gebäudes stellen ebenso wie nachhaltige Sanierungskonzepte hohe Anforderungen an die Bauphysik und dies insbesondere vor dem Hintergrund knapper und teurer werdender fossiler Energieträger. Neben der thermischen Bauphysik, dem Feuchteschutz und dem Brandschutz ist die Akustik ein zentrales Schwerpunktthema der Weimarer Bauphysiktagung. Moderne Verfahren und Berechnungsmethoden und nicht zuletzt Änderungen in der Normung machen einen intensiven fachlichen Austausch unentbehrlich, der in Weimar regelmäßig zu spannenden Diskussionen mit interessanten Kollegen führt. Der vorliegenden Tagungsband beinhaltet Paper zu allen Vorträgen der Weimarer Bauphysiktagung 2011 sowie Beiträge der Posterausstellung.
Using Geographical Information System (GIS)-based watershed characteristics to predict stream visual assessment scores
Creators: name: Fyock, Ellen L.
Publisher: name: No Publisher Supplied
Year: 2008

description: The Stream Visual Assessment Protocol (SVAP) was designed as a cost-effective measurement of stream condition that can be used by non-scientific individuals with minimal training. It is intended as a preliminary assessment to determine problem areas where further study is needed. Although the SVAP is a simple assessment, resources are still required to train staff and volunteers on the protocol and to spend days in the field collecting data. However, if existing data can be used to obtain comparable stream health information without requiring field work, the cost associated with these resources can be reduced. This research investigated whether models can be created using previously collected SVAP data and GIS-based watershed characteristics to evaluate stream conditions to eliminate field work.Using GIS, characteristics such as basin area and stream size were calculated for the areas draining into SVAP assessment locations. Digital data was used to determine characteristics based on land use/cover and soils. Statistical models were created using SVAP data from the Ramapo watershed in northeastern New Jersey. Models significant at α = 0.10 or lower were applied to the Wanaque watershed to determine whether the SVAP scores can be predicted in another location. While the regression models generally explained a high amount of variance in the Ramapo SVAP scores, the SVAP scores for Wanaque could not be accurately predicted from the test models.
The platonic rhetor in the Second Sophistic
Creators: name: Fowler, Ryan Coleman
Publisher: name: No Publisher Supplied
Year: 2008

description: This dissertation looks at four authors (all "unqualified Second Sophists") whose literary activity covers the same period in the latter half of the second century: Lucian of Samosata, Maximus of Tyre, Publius Aelius Aristides of Mysia, and Lucius Apuleius of Madaura. Though born and in general operating at the geographic periphery of the Greco-Roman world, these second-century authors wrote with profoundly acculturated voices. At the same time, there was great concern in their work to emulate the themes and language of Classical Greece, and thereby add their names to the long tradition of Greek thought. The friction between various cultural trends such as the centripetal force of Rome, the movement of the Sophists around the East, and the importance of the tradition of fifth- and fourth-century Greek letters adds a particular force to their treatment of Plato. For these authors hailing from Asia and Africa, one strategy of appealing to past Hellenic literary glory was to invoke Plato and the tradition of Platonism. This dissertation aims to describe the backbone of the Middle Platonic tradition in order to identify the significant influence Plato had on nearly all the literature from the Second Sophistic.
Solid oxide fuel cells developed by the sol-gel process for oxygen generation
Creators: name: Finch, Joshua S.
Publisher: name: No Publisher Supplied
Year: 2008

description: Electrochemical fuel cells convert chemical energy directly to electrical energy through the reaction of a fuel and an oxidant.  Solid oxide fuel cells (SOFC) are solid-state devices that operate at temperatures around 800oC, using a solid oxygen electrolyte.  The goal of this thesis is to prepare a defect-free solid oxygen electrolyte by a sol-gel process that is capable of (a) functioning in a fuel cell and (b) producing measurable oxygen when operated as an oxygen generator.Sol-gel processing was chosen for membrane development because it offers a means of applying high-purity layers with controlled doping and a variety of geometries.  In this study, the sol-gel process was used to produce yttria-stabilized zirconia (YSZ) electrolyte membranes as well as the electrodes required for an operational fuel cell.  Zirconium oxychloride (ZOC) was used as the precursor material for the electrolyte.  The YSZ solution was prepared by mixing yttrium nitrate and ZOC in a 50/50 ETOH and water solvent.  The reaction was catalyzed with 1.5M NH4OH.  Viscosity and solution application techniques were varied to monitor the effect on membrane development.  The YSZ layer was sintered to full density.The sol-gel process was used to synthesize supported lanthanum strontium manganate (LSM) electrodes separated by a YSZ electrolyte.  The LSM solution was made by mixing strontium nitrate, lanthanum chloride, and manganese acetate solutions.  The LSM layers were sintered but were porous.  After the membranes were assembled by successive layering and sintering, the membranes and completed fuel cells were characterized using TGA, XRD, FE-SEM, a gas pressurization technique, and electrochemical testing.The YSZ membrane exhibited a stable tetragonal crystal phase and formed a triple phase boundary (TPB) with the cathode.  The three phases are the electrode, the electrolyte, and air.  Electrochemical testing showed successful membrane development.  Although oxygen production was not measured quantitatively, voltage was produced during hydrogen testing.  A maximum voltage of 0.352V was obtained using forming gas as a fuel.  The relationship between the TPB and oxygen production is critical.  By using the sol-gel process, it is possible to form a TPB where the YSZ electrolyte is dense.
The 4-1-9 coalition, the internet, and Nigerian business integration in the United States
Creators: name: Eleanya, Conleth
Publisher: name: No Publisher Supplied
Year: 2008

description: This dissertation explores how the presentation of the advance fee fraud on the Internet and its association with Nigerians might impact Nigerian immigrants engaged in business in the United States. It examines the nature of Internet contents regarding the advance fee fraud and how they characterize Nigerians in relation to the scams as background to its main objective.  It studies the above issues relating to the advance fee fraud as presented on the Internet and its possible impacts on the Nigerian immigrant business people from the theoretical perspective of constructionism, framing effect, and cultural theories, which underline the mediated nature of reality and media content.  Exponents of these theories insist that both the media and audience are engaged in the negotiation and construction of meanings facilitated through the use of language, thereby highlighting the subjective aspect of human knowledge. This research employed both quantitative and qualitative methodology, namely, content analysis, depth interviews and focus group interviews.  Content analysis of Internet samples was undertaken to determine the nature of Internet contents about the Nigerian involvement in the advance fee fraud.  Interviews with Nigerian immigrant business people provided their perspectives from a face-to-face and non-directive discourse.This dissertation finds that the greatest problem for the Nigerian immigrant business people is their perception of being unfairly stereotyped in reference to the scams, which they say impacts them in several negative ways to the extent that some are unable to grow their businesses or embark on new ones.  The analysis of Internet content on the advance fee fraud also provides strong evidence that Nigerians are stereotyped as fraudulent people, and this hits at the heart of business.  This dissertation underscores the role of communication as a mediator of reality through the use of language, points to the limitations of the Internet as a medium of communication, and speaks to the reality of media effects.
Individual and gender differences in nicotine sensitivity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Gender and stress responsivity are important regulatory factors in human smoking behavior. Both animal and human studies clearly indicate that females respond differently to nicotine, the psychoactive component of tobacco. For example, women are more sensitive to mood changes after smoking and during smoking abstinence than men. Animal research also indicates that the motivation to get nicotine is greater in females. There exist dynamic, bi-directional interactions between nicotine and the stress system. Nicotine activates the stress system and increases glucocorticoid release. Glucocorticoid, in turn, modulates nicotine sensitivity. Biological responses to stress are greatly different between individuals, and are implicated in differential sensitivity toward abused drugs. The development of the stress system is strongly influenced by early rearing conditions. Using animal models of early environmental manipulation, studies have shown that these environmental factors contribute to long-term changes in the developing offspring’s ability to deal with stress and vulnerability to abused drugs in adulthood. Recently, I have found that early environmental manipulation differentially affects male and female rats. Early postnatal handling dampened endocrine stress reactivity in male offspring while potentiating stress reactivity in female littermates. These differences in stress reactivity are also reflected in brain activity. Although nicotine is known to modulate the stress system, there has been no systemic analysis of nicotine effects in these animals. We will test the hypothesis, using this animal model, that male and female rats with differential stress reactivity respond to nicotine with different sensitivity. We will measure hormonal, neuroanatomical and behavioral changes after nicotine administration and, ultimately, compare the differences between male and female’s response to the reinforcing effect of nicotine. Data from the current study will provide evidence as to differential stress reactivity may be a regulating factor in initiation of tobacco use and progression to nicotine addiction. Furthermore, data from this study will improve understanding of how nicotine addiction may differ by gender. The combined biochemical and behavioral data from this study should provide a conceptual framework to develop more effective tobacco use prevention and interventions in gender-specific and individual-specific ways.
Water quality design storms for stormwater hydrodynamic separators
Creators: name: Fernandez, Victoria Julia
Publisher: name: No Publisher Supplied
Year: 2008

description: Stormwater runoff has become an important source of non-point pollution for surface waters. Management practices such as the installation of hydrodynamic separators are implemented in order to treat the stormwater runoff.  In New Jersey, the efficiency of these devices is verified and certified by NJCAT and NJDEP, respectively. When the measure of the device performance is based on laboratory data, NJCAT calculates the average annual removal efficiency using weighting factors. The weighting factors were developed by NJDEP based on the average annual distribution of runoff volumes and the assumed similarity with the distribution of runoff peak flow rates. In this study, 10 years of precipitation records were used to evaluate the frequency distributions of the runoff volumes as well as the runoff peak flow rates. USEPA's SWMM model was used to simulate the runoff events produced by the given precipitation events.  From the model results, three sets of weighting factors were determined.  The first was based on the runoff volume frequency distribution expressed as percentage of the volume produced by the water quality design storm (uniform or non-uniform). The second was based on the runoff peak flow rates frequency distribution expressed as percentage of the peak flow rate generated by the uniformly distributed water quality design storm. The third was also based on the runoff peak flow rates frequency distribution, but expressed as percentage of the peak flow generated by the non-uniformly distributed water quality design storm.   The results indicate that the weighting factors, based on the peak runoff rates generated from the uniform design storm, are the closest to the NJDEP weighting factors. The impact of two different water quality design storms, uniform vs. non-uniform distribution, on the sizing of a certified hydrodynamic separator was also evaluated.   One sets the design flow rate of the device equal to the peak flow rate generated by the uniform design storm. The other sets the design flow rate of the device equal to the peak flow rate generated by the non-uniform design storm. USEPA's SWMM model was used to continuously simulate solids loading to the treatment device. The lab-measured relationship between flow rate and removal efficiency was used to specify the removal rate of solids within the storm event.  The results indicate that sizing with the uniform design storm would achieve a removal efficiency close to the one verified but that sizing with the non-uniform storm would achieve a removal efficiency significantly higher than the one verified.It is concluded that setting design flow rate equal to the peak flow rate generated by the uniform water quality design storm is more consistent with use of the existing weight factors in calculating the average annual solids removal efficiency. Use of the non-uniform water quality design storm is too conservative.
Tympanoterpes elegans Berg 1882
Creators: name: Sanborn, Allen F.
name: Heath, Maxine S.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Tympanoterpes
Tympanoterpes elegans

description: Tympanoterpes elegans Berg, 1882
Tympanoterpes elegans Berg 1882: 40 (type material examined).
Type locality. Argentina, Montevideo, Uruguay, and Brazil.
Remarks. The species was reported from Argentina, Brazil, and Uruguay (Metcalf 1963a). It was reported from the Entre Rios and Santa Fe Provinces (Berg 1882; Bolcatto et al. 2006; De Santis et al. 2007) in Argentina. The reference to Buenos Aires (Metcalf 1963a) is actually in reference to the museum housing specimens studied by Berg (1882). We collected specimens in Córdoba, Entre Rios, La Pampa, Rìo Negro, and San Luis Provinces. The species is associated with the Espinal and Pampas floristic provinces (Sanborn et al. 2011a).
New provincial records. Cordoba, 23–25 km N Huinea Renanco, 10-XII-1986, J.E. Heath Coll. (one male, MSHC); Cordoba, 34 km So. Of Salsacate, 14-XII-1986, F. Noriega Coll. (one male, MSHC); Cordoba, 34 km So. Of Salsacate, 14-XII-1986, Al Sanborn Coll. (one male, MSHC); La Pampa, Junction Rts. 188 & 35, 10-XII-1986, Al Sanborn Coll. (one male, AFSC); La Pampa, Junction Rts. 188 & 35, 10-XII-1986, M.S. Heath Coll. (one male, MSHC); Rio Negro, 56 km E Choele Choel, 9-XII-1986, F. Noriega coll. (two males, MSHC); Rio Negro, 56 km E Choele Choel, 9-XII-1986, J.E. Heath Coll. (one male, MSHC); Rio Negro, 56 km E Choele Choel, 9-XII-1986, M.S. & J.E. Heath Coll. (one male, MSHC); Rio Negro, 56 km E Choele Choel, 9-XII-1986, M.S. Heath Coll. (two males, MSHC); Rio Negro, 56 km E Choele Choel, 9-XII-1986, A. Sanborn Coll. (three males, MSHC); San Luis, 4 km N San Jose del Morro, 11-XII-1986, M.S. Heath Coll. (one male, MSHC); San Luis, 3 km S Rt 8 on Rt 148 btw Noschet & Concaran, 5-XII-1981, M.S. & J.E. Heath Coll., EX: Bunchgrass (five males, MSHC).
description: Published as part of Sanborn, Allen F. & Heath, Maxine S., 2014, The cicadas of Argentina with new records, a new genus and fifteen new species (Hemiptera: Cicadoidea: Cicadidae), pp. 1-94 in Zootaxa 3883 (1) on page 63, DOI: 10.11646/zootaxa.3883.1.1, http://zenodo.org/record/4951252
Graded traces and irreducible representations of Aut(A(Gamma)) acting on graded A(Gamma) and A(Gamma)!
Creators: name: Duffy, Colleen M.
Publisher: name: No Publisher Supplied
Year: 2008

description: In this work we will study the structure of algebras A(Gamma) associated to directed, layered graphs.  The algebras for which we find a decomposition are the algebras related topseudo-roots of noncommutative polynomials and algebras associated to the Hasse graphs of polytopes, to the lattice of subspaces of afinite-dimensional vector space over a finite field, and to the complete layered graph.  We will first find the filtration-preserving automorphism group of these algebras and develop methods of calculating the graded trace of an automorphism acting on the algebra.  We will then find the multiplicities of the irreducible representations of Aut(A(Gamma)) acting on thehomogeneous components of A(Gamma) and A(Gamma)^!. The methods developed lead us to consider subalgebras of graded A(Gamma).
Multibody computational biomechanical model of the upper body
Creators: name: Dubowsky, Sarah Rebecca
Publisher: name: No Publisher Supplied
Year: 2008

description: In the US alone, more than 10,000 spinal cord injuries (SCI) are reported each year.  Those who use a manual wheelchair (WC) depend upon their upper limbs to provide a means of locomotion during completion of their activities of daily living.  As a result of greater than normal usage of the upper limbs, shoulder pain and pathology is common among manual wheelchair users (MWUs).  The use of a patient-specific computational biomechanical model of WC propulsion may help guide rehabilitation that may improve clinical instruction and patient performance.  The focus of the work will be two-fold: 1.) experimentally investigate the simultaneous kinematics, kinetics, and electromyography (EMG) throughout WC propulsion, and 2.) computationally, use these data for the creation and validation of a computational model examining resulting shoulder joint forces.1.)Experimentally: An integrated data collection and analysis of kinematics, kinetics, and EMG data allow for the comparison of differences in WC propulsion between able-bodied and persons with paraplegia.  Resulting muscle activity differences may be responsible for the observed kinematic and kinetic disparities between the two groups.  The high incidence of shoulder pain in MWUs may be the result of such differences. 2.)Computational: When prescribing a WC, the use of a computational model may aide in determining an axle placement in which shoulder joint forces are at a minimum.  Created from the information collected above, a patient-specific model was used to calculate the magnitude of shoulder joint forces throughout propulsion.  In addition, results from a parametric study, determine the effect of axle placement on the magnitude of these forces.  The overall goal is to find an ideal axle placement that minimizes the magnitude of these forces throughout propulsion.    In summary, the current patient-specific computational model can serve as a rehabilitative guide in WC prescription.  With its ability to identify varying magnitudes of compressive loads in different axle positions, clinicians can target the resulting axle positions that minimize shoulder joint forces as an ideal set-up when prescribing a WC.  In turn, minimizing joint forces from injury onset may prolong a MWU's pain-free propulsion and quality of life.
Triglyceride metabolism: Genetics, smoking and heart disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Coronary heart disease (CHD) is the leading cause of death in the United States and the world. The most common cause of CHD is atherosclerosis, which is characterized by the accumulation oflipids in the arterial wall, leading to a narrowing of the lumen and a heart attack. Several risk factors have been identified, including plasma lipid abnormalities, such as elevated cholesterol or triglycerides, and environmental or lifestyle factors, such as smoking. Elevated plasma triglycerides can represent an independent risk factor or be associated with low levels of high density lipoprotein cholesterol (HDL-C). Smoking accentuates the detrimental effects of various risk factors and is also associated with elevated triglyceride levels. A better understanding of the atherosclerotic process, including the factors that regulate plasma triglycerides, may lead to novel

 ways to control plasma lipids and thus counteract the harmful effects of smoking on the atherosclerotic process.

 The present study is designed to understand the role of the microsomal triglyceride transfer protein(MTP) on plasma triglyceride levels. This protein, which is produced in the liver, is critical for transferring lipids, including triglycerides, to the precursors of plasma very low density lipoprotein (VLDL) particles. VLDL are triglyceride-rich lipoproteins. In a large population study we have shown that genetic variation in the structure of the MTP gene can be associated with high plasma triglyceride levels. Importantly, we have shown that these genetic variations in MTP can interact with apolipoprotein (apo) E isoform–specific genotypes to enhance further plasma triglyceride levels. Previously, it was shown that the apoE4 isoform was associated with elevated triglycerides and thus the interaction between apoE4 and MTP could help to explain this observation. In addition, we have found that genetic variations in MTP and smoking interact to cause high triglyceride levels. Therefore, understanding how various factors, including MTP and apoE, interact could lead to important new data related to smoking and CHD.

 Specific Aim 1 is to generate transgenic mice expressing low and high levels of MTP activity in their livers. This will allow us to understand how MTP regulates triglyceride and VLDL levels. In Specific Aim 2 we will cross the human MTP transgenic mice with either apoE3- or apoE4-expressing mice to determine the effect of apoE phenotype on MTP-modulated triglyceride metabolism. Plasma lipids and lipoproteins, including VLDL-triglyceride and apoB production, will be studied in these animal models.
Structure of CYP2A6: the principal nicotine oxidase
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The significant social cost and health risks associated with tobacco have prompted a continued effort to reduce and ultimately eliminate it’s use. The identification of nicotine as the primary addictive component has spawned a therapeutic approach termed “nicotine replacement” to help diminish the grasp of addiction. The logic is simple and compelling. Nicotine provided in the form of chewing gum, skin patches or oral medications is used to replace tobacco as the source of nicotine. However, the body’s ability to rapidly degrade and remove nicotine has been a major obstacle to realizing the full benefits of this approach because of the difficulty in maintaining blood levels that are sufficient to curb craving while remaining below levels that cause nausea and toxicity.

 One enzyme, designated CYP2A6, is primarily responsible for the breakdown and removal of nicotine. Recent research indicates that chemical compounds that block the activity of this enzyme can stabilize nicotine levels and enhance the effectiveness and reliability of nicotine replacement therapy. The objective of the research proposed in this application is to determine the structure of the CYP2A6 enzyme using a technique of x-ray crystallography. X-ray crystallography will allow us to build a comprehensive model of the enzyme down to the atomic positions of all the atoms. This will aid us in the characterization of the features that determine inhibitor binding which will provide critical information for the eventual design of drugs that can efficiently and specifically disrupt nicotine inactivation by CYP2A6. A three dimensional model of the enzyme will enable inexpensive and rapid computer searches and simulations to identify and evaluate likely inhibitors.
Welding Defects
Creators: name: Hadzihafizovic, Dzevad
Publisher: name: Dzevad Hadzihafizovic's Lab
Year: 2022

description: Welding Defects

Weld defect is any flaw or imperfection that compromises the intended use of a weldment. These are classified according to ISO 6520. This also implies a flaw or imperfection may not compromise the weld, and a weld is said to have a discontinuity when this occurs. So, a weld can have a discontinuity and not be considered defective. These acceptable limits are specified in ISO 5817 and ISO 10042. However, if enough discontinuities exist (i.e., they exceed a limit as defined in an applicable code or specification), then the discontinuities become classified as defects, and the weld is rejected. A weld must be strong enough for the intended purpose at the most basic level, and many defects can weaken a joint. But in some cases, your weld must be aesthetically pleasing, too. So, most defects either weaken a weld or make it look ragged and unpresentable. We all want to avoid having our welds fail or be rejected. So, you need to know the types of defects that can occur and how to avoid them. 13 Common Types Of Weld Defects There are many types of welding defects, but in general, the most common weld defects are: Cracks Inclusions Lack of fusion Porosity Undercut Poor penetration Burn through Under-fill Excess reinforcement Spatter Over-roll/Overlap Whiskers Mechanical damage Irregular welds include too wide or too narrow, those with an excessively convex or concave surface, and those with coarse, irregular ripples. These characteristics may be caused by poor torch manipulation, a speed of travel that is too slow, current that is too high or low, improper arc voltage, improper stick out, or improper shielding gas. But when a particular defect occurs, you want to know which parameter needs adjusting so you can fix it. Therefore, a list by defect type, along with how to correct the problem, is helpful.
Mechanism of TGF-a shedding in lung cancer development
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It has long been known that cigarette smoke can lead to lung damage that begins with an inflammation response and could eventually result in tumor formation. A key player in this process is thought to be Transforming Growth Factor a (TGF-a), a protein that can activate cell proliferation when binding to its receptor, EGFR (epidermal growth factor receptor). TGF-a and EGFR are required to promote lung cells to form tumors. Although both benign and tumorigenic human lung cells can produce TGF-a, the cells that are capable of forming tumors express increased amounts of TGF-a. In addition to its expression level, the activity of TGF-a is also regulated. One such activity modification is by protein cleavage that will release TGF-a from cell membrane to form a soluble protein. In soluble form TGF-a can act on neighboring (e.g. stromal) cells and also provide a positive proliferation feedback to the same cells where it was produced. Soluble TGF-a can also be internalized together with its receptor, EGFR, and this is associated with a poor prognostic outcome in patients. The key to cleavage of transmembrane TGF-a is a transmembrane metalloproteinase enzyme, called TACE. Induction of TACE phosphorylation by cigarette smoke correlates with induced TGF-a cleavage.

 The aims of this proposal are to study the regulation of TACE-mediated TGF-a cleavage and its effects on cancer progression. We will investigate whether TACE is regulated from the inside of cancer cells via the Erk/MAPK pathways of signaling. We propose to identify the precise region of TACE that becomes phosphorylated, and determine whether there are existing or unknown proteins that interact to influence TACE activation. Lung cancer cells will also be treated with ectodomain cleavage blockers and monitored for their response to cigarette smoke by examining key cancer markers.

 This study will not only expand our knowledge of the transition from normal epithelial to lung cancer cells, but also could identify new potential drug targets for cancer prevention and treatment.
Swiss Google Books for Research - Experimentierfeld für LLM-Methoden
Creators: name: Reisacher, Martin
name: Dubey, Eric
name: Lorenzini, Matteo
name: Rüdiger, Tim
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Digital humanities
subject: Library sciences
subject: Artificial intelligence

description: Die Bibliotheken UB Bern, ZHB Luzern, ZB Zürich und UB Basel arbeiten mit Google Books zusammen, um einen grossen Teil ihrer Monografien aus den Jahren 1700 bis 1900 zu digitalisieren. Mit fast 300’000 Bänden und über 90 Millionen Volltextseiten entsteht eines der grössten digitalisierten Korpora der Schweiz, das Potenzial für datengetriebene Forschung und Lehre bietet. Unser Projekt analysiert Szenarien, wie dieses Datenset optimal für die Wissenschaft bereitgestellt werden kann.
Asynchronous data transfers on large scale HPC systems with experiments on the CRAY XT3/XT4
Creators: name: Docan, Ciprian
Publisher: name: No Publisher Supplied
Year: 2008

description: A key challenge faced by the emerging large scale scientific and engineering simulations is effectively and efficiently managing the large volumes of heterogeneous data generated. This includes offloading this data from the compute nodes at runtime, and transferring it over to service nodes or remote clusters for onlinemonitoring, analysis, or archiving. To be effective, these I/O operations should not impose additional synchronization penalties onthe simulation, should have minimal impact on the computational performance, maintain overall Quality of Service, and ensure that no data is lost.This thesis describes the design, implementation, and operation of DART (Decoupled Asynchronous Remote Transfers). DART is a thin software layer built on RDMA (Remote Direct Memory Access) communication technology, and specifically the Portals RDMA library to allow fast, low-overhead access to data from simulations running on compute elements, and to support high-throughput low latencyasynchronous I/O transfer of this data.DART is part of the infrastructure for an integrated simulation of fusion plasma in a Tokamak being developed at the Center for Plasma Edge Simulation (CPES), a DoE Office of Fusion Energy Science (OFES) Fusion Simulation Projects (FSP). A performance evaluation on the Cray XT3/XT4 system at Oak Ridge National Laboratory demonstrates that DART can be used to offload expensive I/O operations to dedicated service nodes allowing more efficient utilization of the compute elements.