cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention
Creators: name: Hanley, Gillian E.
name: McAlpine, Jessica N.
name: Miller, Dianne
name: Huntsman, David G.
name: Schrader, Kasmintan A.
name: Blake Gilks, C.
name: Mitchell, Gillian
Publisher: name: BioMed Central
Year: 2018

description: Background: Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast cancer. There are five major histologic subtypes of ovarian cancer and high grade serous cancer (the most common) is reported in 75–100% of BRCA1 and BRCA2 mutation carriers. We examined histology-based referral to the Hereditary Cancer Program following an educational prevention campaign recommending BRCA1 and BRCA2 mutation screening for all high-grade serous cancer patients. Methods: We conducted a population-based retrospective study in the province of British Columbia, Canada that included all patients visiting the Hereditary Cancer Program for genetic counselling for BRCA1 and BRCA2 mutation between 2001 and 2014. We examined the difference in rates of BRCA1 and BRCA2 testing between serous cancer patients and endometrioid and clear cell cancer patients using a differences in differences analysis. We also calculated the mean number of family members tested for every BRCA1 and BRCA2 identified ovarian cancer patient before and after the educational campaign. Results: There were 5712 women tested for a BRCA1 and BRCA2 mutation at the HCP between 2001 and 2014, 887 of which had previously received a diagnosis of ovarian cancer. By 2013, 43% of serous cancer patients were being tested for BRCA1 and BRCA2 mutations compared with 20% of endometrioid and clear cell patients (p < 0.001). The mean number of family members tested for each BRCA1 and BRCA2 positive ovarian cancer patient increased after the educational campaign from 2.54 to 3.27 (p = 0.071), and the number of family members identified as BRCA positive also increased significantly. Conclusions: Recommendations for histology-based referral significantly increased the likelihood of serous cancer patients being tested for BRCA mutations. There was also an increase in the number of carrier tests performed for each BRCA1 and BRCA2 index ovarian cancer patient.
Révision taxinomique des genres Solea, Barnardichthys, Dagetichthys et Synaptura sensu Chabanaud, 1928 (Soleidae; Pleuronectiformes) et phylogénie du genre Dagetichthys
Creators: name: Vachon, Josiane
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Genetics.

description: The examination of type and non-type specimens and of original descriptions for several nominal species of the genus Solea allowed me to determine that among the 97 nominal species, only eight species are valid. They are Solea solea, S. senegalensis, S. aegyptiaca, S. turbynei, S. ovata, S. stanalandi, S. elongata and S. heinii. I provide a new description for the genus with comments on its phylogenetic position, and a new description for each species. I also resurrect the genus Barnardichthys Chabanaud, 1927b for the species Solea fulvomarginata Gilchrist, 1904. I provide an identification key to species of Solea. The second part of the work is a revision of the genus Dagetichthys Stauch and Blanc, 1964, including the species that were traditionally described as Synaptura sensu Chabanaud, 1928, with a description and the phylogeny of these species. I first determined that the five species in the genus Synaptura sensu Chabanaud, 1928, were forming a monophyletic group with Dagetichthys lakdoensis as its sister group. As Synaptura has never been a valid genus name, I assigned the Synaptura sensu Chabanaud, 1928, species to the genus Dagetichthys. Its sister group is Buglossidium luteum (Risso, 1810). From the most plesiomorphic to the most apomorphic, the species are D. lakdoensis Stauch and Blanc, 1964, D. marginatus Boulenger, 1900, D. lusitanicus Brito Capello, 1868, D. commersonnii (Lacepede, 1802), D. albomaculatus Kaup, 1858, and D. cadenati Chabanaud 1948. I discuss a biogeographic scenario explaining the distribution of species and I give an identification key to species.
Dependence of implant-bone micromotion on total ankle replacement design features, amount of interference press-fit, and local bone density
Creators: name: Clarke, Gabriel Arthur
Publisher: name: University of Iowa
Year: 2026
Subjects: Ankle
FEA
Rehabilitation
Total Ankle Replacement
Orthopedics

description: Ankle Osteoarthritis (OA) is a debilitating disease that in end-stage has impairment comparable to that of end-stage kidney disease or congestive heart failure. A common treatment option for end-stage ankle OA is total ankle replacement (TAR). Unfortunately, TAR has relatively poor survivorship compared to hip and knee replacement. TAR failure is linked to initial implant stability, but little is known about the complex mechanics at the implant-bone interface. The work detailed in this thesis improves upon existing knowledge of TAR implant bone interfacial mechanics and how implant fixation (line-to-line or interference fixation), implant design, and patient bone density influence early stability, which is indicative of long term survivorship.
description: Finite Element Analysis models were developed to analyze the behavior of the tibial components of TAR implants through the stance phase of the gait cycle. Implant performance was quantified by calculating the micromotion between the implant and the bone at discrete steps in simulated gait. Micromotion results show how interference-fit fixation improves implant stability, how different implant designs uniquely resist multiaxial loading, and how implant behavior is highly dependent upon patient-specific bone density.
description: Implant stability may be achieved through the proper implantation (interference fixation) of an appropriate implant design, chosen specifically for a patient’s bone density. A better understanding of bone-implant mechanics may help us prescribe the most effective treatment option for patients undergoing TAR, leading to improved implant survivorship.
Exile from the actual: Delmore Schwartz and the difficult inheritance of T. S. Eliot.
Creators: name: Richardson, Scott.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Literature, Modern.

description: In his earliest work, American writer Delmore Schwartz takes his cue from the writings of T. S. Eliot. Schwartz's experience is representative of his generation's experience, but his intense devotion to Eliot's work and person is highly idiosyncratic. Eliot's legacy soon becomes troublesome. Schwartz watches Eliot create a distant, authoritative persona in exile, yet as he narrates his own family's stories of emigration, Schwartz wonders if one can ever truly transcend determined identity. Exile for Schwartz is primarily an attitude toward experience. Eliot exemplifies that attitude. We thrives on the distance of exile; his poetry is seen by Schwartz as a striving for ideal order. Schwartz begins during the 1940s and 50s to mistrust such idealism and find value in the disorderly actuality of American life. He looks to new artistic heroes like James Joyce to replace Eliot. The new aesthetic of celebration, however, coexists uneasily with Schwartz's instinct for criticism.
Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α
Creators: name: Brill, Christina
name: Scheuer, Till
name: Buehrer, Christoph
name: Endesfelder, Stefanie
name: Schmitz, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Glial progenitors
subject: Paediatric research
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The premature increase of oxygen tension may contribute to oligodendroglial precursor cell (OPC) damage in preterm infants. Fetal OPCs are exposed to low oxygen tissue tensions not matched when cells are cultured in room air. Maturation (A2B5, O4, O1, MBP, CNP, arborization), oxidative stress (nitrotyrosine Western blot, NRF2 and SOD2 expression), apoptosis (TUNEL), proliferation (Ki67), and expression of transcription factors regulated by Hypoxia-Inducible-Factor-1-alpha (Hif-1α) expressed in OPCs (Olig1, Olig2, Sox9, Sox10) were assessed in rat OPCs and OLN93 cells cultured at 5% O2 and 21% O2. Influences of Hif-1α were investigated by Hif-1α luciferase reporter assays and Hif-1α-knockdown experiments. At 21% O2, cell proliferation was decreased and process arborization of OPCs was reduced. Expression of MBP, CNP, Olig1, Sox9 and Sox10 was lower at 21% O2, while Nrf2, SOD2, nitrotyrosine were increased. Apoptosis was unchanged. Luciferease reporter assay in OLN93 cells indicated increased Hif-1α activity at 5% O2. In OLN93 cells at 5% O2, Hif-1α knockdown decreased the expression of MBP and CNP, similar to that observed at 21% O2. These data indicate that culturing OPCs at 21% O2 negatively affects development and maturation. Both enhanced oxidative stress and reduced expression of Hif-1α-regulated genes contribute to these hyperoxia-induced changes.
Cosmic dynamics in the era of Extremely Large Telescopes
Creators: name: Liske, J.
name: Grazian, Andrea
name: Vanzella, E.
name: Dessauges, M.
name: Viel, M.
name: Pasquini, L.
name: Haehnelt, Martin G.
name: Cristiani, Stefano
name: Pepe, Francesco
name: Avila, G.
name: Bonifacio, P.
name: Bouchy, François
name: Dekker, H.
name: Delabre, B.
name: D'Odorico, S.
name: D'Odorico, V.
name: Levshakov, Sergei A.
name: Lovis, C.
name: Mayor, M.
name: Molaro, Paolo
name: Moscardini, L.
name: Murphy, Michael
name: Queloz, D.
name: Shaver, P.
name: Udry, S.
name: Wiklind, T.
name: Zucker, S.
Publisher: name: Swinburne
Year: 2024

description: The redshifts of all cosmologically distant sources are expected to experience a small, systematic drift as a function of time due to the evolution of the Universe's expansion rate. A measurement of this effect would represent a direct and entirely model-independent determination of the expansion history of the Universe over a redshift range that is inaccessible to other methods. Here we investigate the impact of the next generation of Extremely Large Telescopes on the feasibility of detecting and characterizing the cosmological redshift drift. We consider the Lyα forest in the redshift range 2 < z < 5 and other absorption lines in the spectra of high-redshift QSOs as the most suitable targets for a redshift drift experiment. Assuming photon-noise-limited observations and using extensive Monte Carlo simulations we determine the accuracy to which the redshift drift can be measured from the Lyα forest as a function of signal-to-noise ratio and redshift. Based on this relation and using the brightness and redshift distributions of known QSOs we find that a 42-m telescope is capable of unambiguously detecting the redshift drift over a period of ∼20 yr using 4000 h of observing time. Such an experiment would provide independent evidence for the existence of dark energy without assuming spatial flatness, using any other cosmological constraints or making any other astrophysical assumption.
Encircling the Liouvillian exceptional points: a brief review
Creators: name: Sun, Konghao
name: Yi, Wei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Exceptional points are the branch-point singularities of non-Hermitian Hamiltonians, and have rich consequences in open-system dynamics. While the exceptional points and their critical phenomena are widely studied in the non-Hermitian settings without quantum jumps, they also emerge in open quantum systems depicted by the Lindblad master equations, wherein they are identified as the degeneracies in the Liouvillian eigenspectrum. These Liouvillian exceptional points often have distinct properties compared to their counterparts in non-Hermitian Hamiltonians, leading to fundamental modifications of the steady states or the steady-state-approaching dynamics. Since the Liouvillian exceptional points widely exist in quantum systems such as the atomic vapours, superconducting qubits, and ultracold ions and atoms, they have received increasing amount of attention of late. Here we present a brief review on an important aspect of the dynamic consequence of Liouvillian exceptional points, namely the chiral state transfer induced by the parametric encircling the Liouvillian exceptional points. Our review focuses on the theoretical description and experimental observation of the phenomena in atomic systems that are experimentally accessible. We also discuss the on-going effort to unveil the collective dynamic phenomena close to the Liouvillian exceptional points, as a consequence of the many-body effects therein. Formally, these phenomena are the quantum-many-body counterparts to those in classical open systems with nonlinearity, but hold intriguing new potentials for quantum applications.
description: 9 pages, 6 figures
Projekt SeEiS - Substitutionseffekte erneuerbarer Energien im Stromsektor
Creators: name: Kunze, Robert
name: Miehling, Hannes
name: Anke, Carl-Philipp
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Substitutionseffekt
subject: Emissionsbilanz
subject: Erneuerbare Energie
subject: Stromsektor
subject: Klima | Energie

description: Das SeEiS-Forschungsvorhaben zielt auf die Weiterentwicklung der bislang angewandten Methodik zur Emissionsbilanzierung der im deutschen Stromsektor eingesetzten erneuerbaren Energieträger ab. Im Hinblick auf die zunehmende Vernetzung des europäischen Strommarkts sollen zukünftig auch die Effekte des deutschen Stromaußenhandels bei der Emissionsbilanz adäquat Berücksichtigung finden. Hierfür werden die europaweit vermiedenen Erzeugungsmengen aus konventionellen Kraftwerken modellgestützt quantifiziert, welche in den Jahren 2013 bis 2018 durch die Stromerzeugung aus erneuerbaren Energieträgern in Deutschland substituiert wurden. Der vorliegende Abschlussbericht stellt die Ergebnisse sowie die Vorgehensweise und die verwendete Datengrundlage im SeEiS-Projekt vor. Quelle: Forschungsbericht
description: The SeEiS research project aims at the further development of the methodology used so far for emission balancing of the renewable energy sources used in the German electricity sector. In view of the increasing interconnectedness of the European electricity market, the effects of German foreign trade in electricity should be adequately considered in the emissions balance. For this purpose, the avoided conventional electricity generation throughout Europe, which was substituted by electricity generation from renewable energy sources in Germany between 2013 and 2018, is model based analysed and quantified. This final report presents the results as well as the methodology and the data used in the SeEiS project. Quelle: Forschungsbericht
description: Ziel des Forschungsvorhabens „Substitutionseffekte erneuerbarer Energien im Stromsektor“ (SeEiS) ist die Weiterentwicklung der Methodik zur Quantifizierung der verdrängten konventionellen Stromerzeugung durch die deutsche EE-Stromerzeugung. Um die Substitutionseffekte zu ermitteln, wird die reale Entwicklung des europäischen Stromerzeugungssektors einem kontrafaktischen ⁠Entwicklungspfad⁠ vergleichend gegenübergestellt, welcher keine erneuerbaren Energien im deutschen Strommix beinhaltet. Diese Effekte gehen in die am ⁠UBA⁠ erstellte Emissionsbilanz erneuerbarer Energieträger ein. Im vorliegenden Bericht werden die Projektergebnisse für die Jahre 2013-2018 dokumentiert.
Analyse du processus d'intervention pédagogique d'entraîneurs de hockey amateur.
Creators: name: Lapierre, Mathieu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Education, Physical.

description: En pedagogie sportive, plusieurs recherches descriptives ont investigue les comportements des entrai neurs lors de seances d'entrai nement ou de competition (Trudel & Gilbert, 1995). A l'oppose, peu d'etudes ont ete realisees sur la composante organisation/planification et sur le contenu de l'enseignement d'une activite sportive. Or, pour comprendre l'ensemble du processus d'intervention pedagogique des entrai neurs, des recherches sur la planification et l'interaction entrai neur-joueurs sont necessaires. Afin de circonscrire le processus d'intervention pedagogique de trois entrai neurs au hockey mineur, de multiples sources de donnes ont ete utilises: entrevues generales, entrevues pre et post-seances d'entrai nement et de matchs, entrevues post-projet, enregistrements sur bande video des seances d'entrai nement et des matchs, et ainsi que des seances de rappel stimule. Les resultats demontrent que les entrai neurs planifiaient leurs seances d'entrai nement dans le but de developper les habiletes tactiques et techniques de leurs athletes mais planifiaient leurs matchs dans le but de vaincre l'adversaire. De plus, les entrai neurs avaient un pourcentage de congruence entre le contenu de leur planification et le contenu de leur intervention deux fois pius eleve lors des seances d'entrai nement (74%) que lors des matchs (37%).
3854359.pdf
Creators: name: Wiegandt, Amnueporn
name: Anderson, Patrick
name: Yu, Fei
name: Treacher, Daniel
name: Lloyd, David
name: Mosley, Peter
name: Hooker, Simon
name: Walmsley, Ian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: HHG build-up model
Determining metabolic fluxes from metabolomics and stable isotope tracing data
Creators: name: Guppy, Breanna
Publisher: name: University of Iowa
Year: 2024

description: Metabolic fluxes are the reaction rates of biochemical reactions in a metabolic pathway. This thesis examines the capacity to reliably compute estimates of metabolic fluxes from isotopic non-stationary systems in metabolic steady state. Determining the dynamics of these fluxes is critical to understanding the pathophysiology of diseases associated with disruption of normal metabolism.
description: We develop a procedure for translating diagrams of metabolic pathways into mathematical models composed of hybrid systems of differential equations and algebraic constraints. This process begins with the use of graph theory to represent biochemical networks as weighted directed graphs. The method applies to linear, branched, and cyclic pathways. We also establish essential models for extending this approach to include changing metabolite concentration as well as isotope dynamics.
description: Kinetic flux profiling (KFP) is an experimental method for computing fluxes in pathways incorporating isotopic label while in metabolic steady state. The dynamical systems model of this pathway involves parameters describing metabolic fluxes. By re-scaling the dynamical systems model we discover a connection between the diagram of the pathway and the number of parameters required in the model. We use Bayesian parameter estimation on simulated data sets to explore the ability of the method to quantify the model’s parameter values. Bayesian methods allow us to ascertain both the accuracy and the certainty of those estimates. The obstacles preventing precise parameter estimations are articulated using local sensitivity analysis and singular perturbation theory. Parameters associated with metabolites downstream in the pathway are more challenging to estimate.
description: Finally, we extend the KFP models to include reversible reactions between metabolites. The re-scaled models for reversible reactions share the connection between the number of required parameters and components in the diagram. The difficulties of parameter estimation increase with the need to compute additional fluxes. Again using local sensitivity analysis and singular perturbation analysis, we describe the limitations impeding accurate parameter estimations using the Bayesian method. The investigation of both reversible and non-reversible KFP models revealed that accurate parameter estimations are infeasible when a large separation of timescales exists between the turnover rates of upstream metabolites and their downstream products.
High occurrence of disabilities caused by leprosy: census from a hyperendemic area in Brazil's savannah region
Creators: name: Haefner, Kathrin
name: Walther, Friederike
name: Chichava, Olga Andre
name: Ariza, Liana
name: Alencar, Carlos Henrique
name: Freitas De Alencar, Maria De Jesus
name: Ramos, Alberto Novaes
name: Richter, Joachim
name: Heukelbach, Jorg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: leprosy
subject: disabilities
subject: epidemiology
subject: prevention
subject: Brazil
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives: To describe leprosy-related disabilities, we performed a census including people affected by leprosy in 78 municipalities of Tocantins state in northern Brazil. The study consisted of a review of patient charts, structured questionnaires, and clinical examinations for disabilities of eyes, hands, and feet (August – December 2009), according to WHO standards. Results: A total of 910 individuals diagnosed from 2006 to 2008 were included (clinical examination and application of questionnaires), but information from patient charts was not available in all cases, resulting in different denominators. The majority (783/858; 91·3%) had completed multidrug therapy. The most common clinical findings included: enlarged/painful peripheral nerves (412/910, 45·3%), namely of ulnar (207; 22·7%), posterior tibial (196; 21·6%), peroneal (186; 20·5%), and radial cutaneous nerves (166; 18·2%); reduction/loss of sensibility 201/907 (22·2%) and reduced motor function (185/906, 20·4%). At diagnosis, 142/629 (22·6%) had Grade 1 disability (G1D), and 28/629 (4·5%) had Grade 2 disability (G2D). At the time of the study, 178/910 (19·6%) presented with G1D, and 84/910 (9·2%) with G2D. Disability grading was significantly higher in males ( P , 0·01). Subjects with G2D showed claw hands (26; 2·9%), followed by plantar ulcers (23; 2·5%), abrasion/excoriation on the foot (12; 1·3%), claw foot (7; 0·7%), and drop foot (7; 0·7%). Conclusions: Leprosy- related disabilities were common in a highly endemic area. Prevention and rehabilitation measures, especially after release from treatment, should be intensified by the primary health care system. Policy makers need to be aware of an ongoing demand for leprosy control programmes, even in a world of constantly reducing leprosy detection.
Leitfaden zur umweltfreundlichen öffentlichen Beschaffung: Schreibgeräte und Stempel
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2019
Subjects: subject: Beschaffung
subject: Umweltfreundliche Beschaffung
subject: Öffentliche Beschaffung
subject: Umweltfreundliche öffentliche Beschaffung
subject: Produktkennzeichnung
subject: Schreibgeräte
subject: Stempel
subject: Stift
subject: Stifte
subject: Kugelschreiber
subject: Blauer Engel
subject: Umweltzeichen
subject: Wirtschaft | Konsum

description: Schreibgeräte umfassen ein breites Spektrum verschiedenartiger Produkte. Viele Produkte, wie Kugelschreiber oder Bleistift, werden täglich genutzt. Schreibgeräte und Stempel, die die Kriterien des vorliegenden Leitfadens einhalten, zeichnen sich durch folgende Umwelteigenschaften aus: Verwendung ressourcenschonender Materialien, Maßnahmen zur Verlängerung der Nutzungsdauer, Verminderung bzw. Vermeidung gesundheitsbelastender Stoffe und Gemische im Produkt. Der Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel für Schreibgeräte und Stempel (RAL-UZ 200), Ausgabe Januar 2016. Quelle: http://www.umweltbundesamt.de/
description: Schreibgeräte umfassen ein breites Spektrum verschiedenartiger Produkte. Viele Produkte, wie Kugelschreiber oder Bleistift, werden täglich genutzt. Schreibgeräte und Stempel, die die Kriterien des vorliegenden Leitfadens einhalten, zeichnen sich durch folgende Umwelteigenschaften aus: Verwendung ressourcenschonender Materialien, Maßnahmen zur Verlängerung der Nutzungsdauer, Verminderung bzw. Vermeidung gesundheitsbelastender Stoffe und Gemische im Produkt. Der Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel für Schreibgeräte und Stempel (DE-UZ 200), Ausgabe Januar 2016.
The synthetic opioid epidemic and the need for mental health support for first responders who intervene in overdose cases.
Creators: name: Jozaghi, Ehsan
name: Maynard, Russ
name: Dadakhah-Chimeh, Zahra
name: Yake, Kevin
name: Blyth, Sarah
Publisher: name: The University of British Columbia
Year: 2019

Abstract
Wavelet-based coding and indexing of images and video.
Creators: name: Mandal, Mrinal Kumar.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Electronics and Electrical.

description: The multitude of visual media based applications demands sophisticated compression and indexing techniques for efficient storage, transmission, and retrieval of images and video. Wavelet transform has emerged as a powerful tool for efficient compression of images and video sequences. However, there is a need for significant enhancements in the motion estimation process in order to design an efficient wavelet-based video coder. More importantly, there has been little work done in the area of image and video indexing in the wavelet domain. These are crucial for consideration of wavelets as a potential candidate for multimedia applications. Hence there is an impending need for investigating joint compression and indexing approaches in the wavelet transform domain which is the principal focus of this thesis. In this thesis, we have proposed several novel coding and indexing techniques in the wavelet domain. The proposed coding techniques emphasize efficient motion estimation techniques for a wavelet-based video coder, which include bi-directional motion estimation, fine-to-coarse motion estimation, and variable block-size motion estimation. The proposed indexing techniques include moment-based indexing, fast wavelet histogram indexing, indexing based on distribution of wavelet coefficients, illumination invariant indexing, and robust video segmentation. An efficient video storage and archival system has been developed by combining all proposed techniques. The novelty of the coding and indexing techniques is that both employ a set of key features that describe the content of the visual data. This results in superior performance with lower storage space requirement, and reduced computational complexity.
Development of Synthetic Lightweight Aggregates from Fly Ash
Creators: name: Graytee, Ahmed Redha Saleem
Publisher: name: Swinburne
Year: 2024

description: There is an increasing pressure on coal-fired power stations to increase the rate of fly ash utilisation as a best solution for the environmental problems associated with fly ash storage and management. One of the high-value added applications of fly ash is to convert it into lightweight aggregates that can be used to produce lightweight concrete. Manufacturing of economical and good quality fly ash aggregates will reduce the impact of fly ash on the environment and provide a great benefit to the economy. This thesis provides a study on the development of synthetic lightweight aggregates from fly ash using innovative curing techniques which are applied for very short time.
Influence of environment and size on the creep and drying shrinkage of concrete.
Creators: name: Huh, Jungsuck (Ben).
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Civil.

description: In literature a lot of studies about the prediction of creep and shrinkage of concrete at constant temperature and relative humidity can be found. However, when a concrete structure is built in reality, temperature and relative humidity of the environment vary with location and seasons of construction. So it can be expected that the "moment of casting concrete" has an influence on the evolution of creep and shrinkage of that concrete. In order to acquire information regarding the problem of " the prediction of creep and shrinkage due to a time-varying climate history" a research program is going on at the University of Ottawa. The following parameters are examined: curing period, storage environment, specimen size and age of loading. Creep and shrinkage testing of two sets of specimens is described. For the size and environment tests, the 89 mm, 152 mm, 254 mm, and 610 mm diameter cylinders were used. All specimens were exposed to the chosen environment after moist curing 3-4 days and typically loaded at 24 days. For the age of loading tests, 89 mm diameter specimens were loaded at concrete ages raging from 3 to 200 days, 152 mm diameter specimens were loaded at concrete age 24 days, 254 mm diameter specimens were loaded at concrete ages raging from 24 to 200 days, and 610 mm diameter specimens were loaded at concrete age 24 days in each of the chosen environment. The environment wereinside Lab (22°C, variable humidity), Tent 22°C and 50 % relative humidity , outside (uncontrolled temperature and humidity) and immersed in water.
3854359.pdf
Creators: name: Wiegandt, Amnueporn
name: Anderson, Patrick
name: Yu, Fei
name: Treacher, Daniel
name: Lloyd, David
name: Mosley, Peter
name: Hooker, Simon
name: Walmsley, Ian
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: HHG build-up model
Conceptual Design Report: X-Ray Optics and Beam Transport
Creators: name: H. Sinn
name: J. Gaudin
name: L. Samoylova
name: A. Trapp
name: G. Galasso
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2011
Subjects: Physics

description: DESY Technical Report
Addressing goal conflicts: New policy mixes for commercial land use management
Creators: name: Kosow, Hannah
name: Grimski, Detlef
name: Wassermann, Sandra
name: Bartke, Stephan
Publisher: name: My University
Year: 2022
Subjects: Gewerbefläche

description: Commercial land use management that focuses on a future-oriented urban and regional development must address multiple goals. Effective policy mixes need to simultaneously (1) improve city-regional and inter-municipal cooperation, (2) reduce land take, and (3) assure the long-term economic development of a region. Using the Northern Black Forest in Germany as a case study, we brought together planning and land use research with public policy analysis. We applied cross-impact balances (CIB) to build and analyze a participatory policy-interaction model. Together with a group of 12 experts, we selected effective individual measures to reach each of the three goals and analyzed their interactions. We then assessed the current policy mix and designed alternative policy mixes. The results demonstrate that current approaches to commercial land use management present internal contradictions and generate only little synergies. Implementing innovative measures on a stand-alone basis runs the risk of not being sufficiently effective. In particular, the current practice of competing for municipal marketing and planning of commercial sites has inhibiting effects. We identified alternative policy mixes that achieve all three goals, avoid trade-offs, and generate significant synergy effects. Our results point towards a more coherent and sustainable city-regional (commercial) land-use governance. © 2022 by the authors
3854387.pdf
Creators: name: McGrew, William
name: zhang, xiaogang
name: Leopardi, Holly
name: Fasano, Robert
name: Nicolodi, Daniele
name: Beloy, Kyle
name: Yao, Jian
name: Sherman, Jeff
name: Schäffer, Stefan
name: Savory, Joshua
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document
Wie grün müssen Mitteldeutschlands Rechenzentren werden?
Creators: name: Erll, Christian
Publisher: name: My University
Year: 2023

description: Wir streamen Serien, besprechen uns mit Kollegen in der Videokonferenz oder sichern wichtige Dokumente online. Daten lagern oft nicht mehr auf Laptop oder Computern, sondern in großen Servern in Rechenzentren. Da es immer mehr von diesen Rechenzentren gibt, verbrauchen sie auch immer mehr Energie. Den Stromhunger will die Bundesregierung eindämmen - das hat sie im Koalitionsvertrag vereinbart. Wie sollen die Rechenzentren in Mitteldeutschland klimaneutral werden? Quelle: https://www.mdr.de/
In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System
Creators: name: Knöspel, Fanny
name: Jacobs, Frank
name: Freyer, Nora
name: Damm, Georg
name: De Bondt, An
name: Wyngaert, Ilse Van Den
name: Snoeys, Jan
name: Monshouwer, Mario
name: Richter, Marco
name: Strahl, Nadja
name: Seehofer, Daniel
name: Zeilinger, Katrin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: primary human hepatocytes
subject: in vitro hepatotoxicity model
subject: three-dimensional (3D) bioreactor
subject: diclofenac
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the effects of diclofenac, as a model substance with a known risk of hepatotoxicity in vivo, in a dynamic multi-compartment bioreactor using primary human liver cells. Biotransformation pathways of the drug and possible effects on metabolic activities, morphology and cell transcriptome were evaluated. Formation rates of diclofenac metabolites were relatively stable over the application period of seven days in bioreactors exposed to 300 µM diclofenac (300 µM bioreactors (300 µM BR)), while in bioreactors exposed to 1000 µM diclofenac (1000 µM BR) metabolite concentrations declined drastically. The biochemical data showed a significant decrease in lactate production and for the higher dose a significant increase in ammonia secretion, indicating a dose-dependent effect of diclofenac application. The microarray analyses performed revealed a stable hepatic phenotype of the cells over time and the observed transcriptional changes were in line with functional readouts of the system. In conclusion, the data highlight the suitability of the bioreactor technology for studying the hepatotoxicity of drugs in vitro.
Evaluation of restricted driver licensing for medical impairments in Saskatchewan.
Creators: name: Marshall, Shawn Calder.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Health Sciences, Public Health.

description: Driving ability may be adversely affected by many medical conditions and many jurisdictions therefore allow for a restricted license that permits driving under specified conditions. The objective of this retrospective cohort study was to evaluate restricted licensing by comparing "at-fault" crash and traffic violation rates for drivers with a restricted license to the general driving population and also to compare driving pre and post restriction. Following multivariate Poisson regression, the adjusted IRR for "at-fault" crashes and traffic violations for restricted versus non-restricted drivers were 0.92 (95% CI, 0.89 to 0.95) and 0.87 (95% CI, 0.85 to 0.90) respectively. Interventional time series analysis demonstrated a significant decrease in "at-fault" crash and traffic violation rates post imposition of restrictions. Restricted licensing programs are effective and allow persons with decreased driving ability due to medical conditions to continue driving under specific conditions.
title: Not-being-us
title: for sinfonietta ensemble
titleType: Subtitle
Creators: name: Roshandel, Ramin
Publisher: name: University of Iowa
Year: 2024
Subjects: Contemporary Modal Music
Dastgāh
Persian Music Intervals
Radīf
Segāh
Šūr

description: not-being-us, for sinfonietta ensemble, is a three-movement piece and is about 17 minutes in duration.This piece creates a series of structures that are based on the Persian music intervals derived from the radīf. This piece also explores a series of fluid and metamorphic states between the principle tones of the dastgāh šūr and dastgāh segāh. Radīf, the main repertoire of Persian classical music, consists of twelve modes; seven main ones called dastgāh and smaller subgroups called āvāz or māya (or māyé). Each dastgāh or āvāz consists of a series of pre-composed musical units called gūša (or gūšé). In this piece, the electric piano has been re-tuned based on the intervals of the aforementioned dastgāhs.
description: An important aspect of this piece is the liminal spaces that create musical tensions and releases between the tones. The aforementioned liminal structures can either morph into/lean towards more pitch-centric or non-pitch-centric states. They can also create new modal structures using the non-conventional pitches within a dastgāh.
description: The first movement of the piece establishes a fluid atmosphere around the first tetrachord of the dastgāh šūr (شور). As a piano-concerto-esque slow movement, the second movement utilizes the intervals of the dastgāh segāh (سه‌گاه) as well as a series of microtonal intervals between them. The third movement is centered around the clarinet as a soloist. Like the first movement, this movement also uses the dastgāh šūr as a main scale. The electric piano in this piece needs to be connected to a laptop with an installed software that allows the piano to be re-tuned. The piano also needs to be connected to a pair of speakers. The tuning of the first and the third movement is the same and the piano needs to be used as a pitch/tuning reference for the orchestra and the conductor.
gammadelta T cells derived from peripheral blood and cerebrospinal fluid of multiple sclerosis patients: Cytotoxic mechanisms, inhibitory natural killer cell receptors, and protein analysis
Creators: name: Green, Melanie Leslie Dawn
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Biology, Microbiology.
subject: Health Sciences, Immunology.

description: Multiple sclerosis (MS) is characterized by inflammation of the central nervous system, destruction of the oligodendrocyte/myelin unit, demyelination, and axonal loss. MS is believed to result from an autoimmune reaction mediated by alphabeta T cells against the myelin/oligodendrocyte unit. There is, however, increasing evidence that gammadelta T cells are also responsible for the damage observed in the MS brain: gammadelta T cells are found in increased numbers in the peripheral blood (PB) and cerebrospinal fluid (CSF) of MS patients, accumulate in MS lesions, and lyse oligodendrocytes in vitro. The cytotoxic mechanism(s) utilized by gammadelta T cells and the control of these mechanisms are incompletely understood, although it has been reported that gammadelta T cell mediated cytotoxicity can be regulated via inhibitory natural killer cell receptors (iNKR). The work described in this thesis was undertaken to gain a more complete understanding of the cytotoxic mechanism(s) utilized by gammadelta T cells, to investigate the control of gammadelta T cell mediated cytotoxicity by iNKR, and to search for differences in cytotoxic phenotype and function between PB and CSF derived gammadelta T cells. My results have demonstrated that gammadelta T cell mediated cytotoxicity proceeds via the perform/granzyme and Fas/FasL pathways, that granzyme B is an especially potent cytotoxic mediator for these cells, and that the exact method of attack is influenced by the target cell. As well, the cytotoxicity mediated by gammadelta T cells cannot be modulated solely via manipulation of the iNKR/HLA class I molecule interaction, but instead is under the control of a number of inhibitory and activating receptors. It is the balance of the signals these receptors generate that determines the action of the gammadelta T cell. A number of functional and phenotypic differences were observed between PB and CSF derived cells. Two dimensional electrophoretic analyses of protein isolated from PB and CSF derived gammadelta T cells revealed an MS CSF specific protein "profile" consisting of 7 proteins absent from the MS CSF samples.
3854387.pdf
Creators: name: McGrew, William
name: zhang, xiaogang
name: Leopardi, Holly
name: Fasano, Robert
name: Nicolodi, Daniele
name: Beloy, Kyle
name: Yao, Jian
name: Sherman, Jeff
name: Schäffer, Stefan
name: Savory, Joshua
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplemental document
The Over 45s Adult Sexuality and Intimacy Scale: A new approach to understanding and measuring sexuality in mid and later life
Creators: name: Macleod, Ashley
Publisher: name: Swinburne
Year: 2024

description: The five publications comprising this thesis interlink to produce a novel approach to conceptualising the experience of sexuality and related factors for heterosexual adults in mid and later life, and a validated measurement scale that aligns with this new approach (the Over 45s Adult Sexuality and Intimacy Scale; “The OASIS”). This work creates new opportunities to understand the experience of sexuality for heterosexual adults in mid and later life that better reflect the sexual priorities of this cohort, and creates new avenues to examine the experience of sexuality for this cohort beyond measures of sexual functioning and sexual activity frequency.
Vitamin E and arachidonic acid metabolism in cultured human endothelial cells.
Creators: name: Tran, Khai T.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Chemistry, Biochemistry.

description: A novel approach to study the metabolism of nutrients in human cells was developed. The incorporation and depletion of 2R,4$\sp\prime$R,8$\sp\prime$R-$\alpha$-tocopherol (RRR-$\alpha$-T), a natural form of vitamin E, and its subsequent effect on the metabolism of arachidonic acid were conducted on human umbilical vein endothelial cells (HUVECs) in culture. HUVECs incorporated physiological and pharmacological concentrations of RRR-$\alpha$-T in a time- and dose-dependent manner. Incorporated tocopherol was found mainly associated with membrane fractions of the cell. This stimulatory activity of tocopherol has an absolute structural requirement for both free hydroxyl moiety and the hydrophobic phytyl side chain, although the position and the presence of the methyl groups attached to the aromatic moiety are not required for its activity. Direct analysis of enzymes involved in phospholipid metabolism indicated that tocopherol-enrichment caused an increase in phospholipase A$\sb2$ activity without affecting the activities of lysophospholipase or acylCoA-acyltransferase. Hydrogen peroxide when combined with $\alpha$-tocopherol synergistically stimulated basal release of PGI$\sb2$ from endothelial cells. $\alpha$-tocopherol potentiates PGI$\sb2$ synthesis when challenged with exogenous arachidonic acid. (Abstract shortened by UMI.)
Lineage-Specific Real-Time RT-PCR for Yellow Fever Virus Outbreak Surveillance, Brazil
Creators: name: Fischer, Carlo
name: Torres, Maria C.
name: Patel, Pranav
name: Moreira-Soto, Andres
name: Gould, Ernest A.
name: Charrel, Remi N.
name: De Lamballerie, Xavie
name: Drosten, Christian
name: Drexler, Jan Felix
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The current yellow fever outbreak in Brazil prompted widespread yellow fever virus (YFV) vaccination campaigns, imposing a responsibility to distinguish between vaccine- and wild-type YFV-associated disease. We developed novel multiplex real-time reverse transcription PCRs that differentiate between vaccine and American wild-type YFV. We validated these highly specific and sensitive assays in an outbreak setting.
Impact of changing the wet deposition schemes in ldx on 137-cs atmosperic deposits after the fukushima accident
Creators: name: Quérel, Arnaud
name: Quélo, Denis
name: Roustan, Yelva
name: Mathieu, Anne
name: Kajino, Mizuo
name: Sekiyama, Thomas
name: Adachi, Kouji
name: Didier, Damien
name: Igarashi, Yasuhito
name: Maki, Takashi
Publisher: name: arXiv
Year: 2024
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: The Fukushima-Daiichi release of radioactivity is a relevant event to study the atmospheric dispersion modelling of radionuclides. Actually, the atmospheric deposition onto the ground may be studied through the map of measured Cs-137 established consecutively to the accident. The limits of detection were low enough to make the measurements possible as far as 250km from the nuclear power plant. This large scale deposition has been modelled with the Eulerian model ldX. However, several weeks of emissions in multiple weather conditions make it a real challenge. Besides, these measurements are accumulated deposition of Cs-137 over the whole period and do not inform of deposition mechanisms involved: in-cloud, below-cloud, dry deposition. In a previous study (Qu{é}rel et al., 2016), a comprehensive sensitivity analysis was performed in order to understand wet deposition mechanisms. It has been shown that the choice of the wet deposition scheme has a strong impact on assessment of deposition patterns. Nevertheless, a ``best'' scheme could not be highlighted as it depends on the selected criteria: the ranking differs according to the statistical indicators considered (correlation, figure of merit in space and factor 2). A possibility to explain the difficulty to discriminate between several schemes was the uncertainties in the modelling, resulting from the meteorological data for instance. Since the move of the plume is not properly modelled, the deposition processes are applied with an inaccurate activity concentration in the air. In the framework of the SAKURA project, an MRI-IRSN collaboration, new meteorological fields at higher resolution (Sekiyama et al., 2013) were provided and allow to reconsider the previous study. An update including these new meteorology data is presented. In addition, the focus is put on the deposition schemes commonly used in nuclear emergency context.