cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ground-State Electromagnetic Moments of Calcium Isotopes
Creators: name: Ruiz, R. F. Garcia
name: Bissell, M. L.
name: Blaum, K.
name: Frommgen, N.
name: Hammen, M.
name: Holt, J. D.
name: Kowalska, M.
name: Kreim, K.
name: Menendez, J.
name: Neugart, R.
name: Neyens, G.
name: Nortershauser, W.
name: Nowacki, F.
name: Papuga, J.
name: Poves, A.
name: Schwenk, A.
name: Simonis, J.
name: Yordanov, D. T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: High-resolution bunched-beam collinear laser spectroscopy was used to measure the optical hyperfine spectra of the $^{43-51}$Ca isotopes. The ground state magnetic moments of $^{49,51}$Ca and quadrupole moments of $^{47,49,51}$Ca were measured for the first time, and the $^{51}$Ca ground state spin $I=3/2$ was determined in a model-independent way. Our results provide a critical test of modern nuclear theories based on shell-model calculations using phenomenological as well as microscopic interactions. The results for the neutron-rich isotopes are in excellent agreement with predictions using interactions derived from chiral effective field theory including three-nucleon forces, while lighter isotopes illustrate the presence of particle-hole excitations of the $^{40}$Ca core in their ground state.
description: Accepted as a Rapid Communication in Physical Review C
Reciprocal Efficiency of RNQ1 and Polyglutamine Detoxification in the Cytosol and Nucleus
Creators: name: Ren, Hong Yu
name: Douglas, Peter M.
name: Summers, Daniel W.
name: Cyr, Douglas M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Onset of proteotoxicity is linked to change in the subcellular location of proteins that cause misfolding diseases. Yet, factors that drive changes in disease protein localization and the impact of residence in new surroundings on proteotoxicity are not entirely clear. To address these issues, we examined aspects of proteotoxicity caused by Rnq1-green fluorescent protein (GFP) and a huntingtin's protein exon-1 fragment with an expanded polyglutamine tract (Htt-103Q), which is dependent upon the intracellular presence of [RNQ+] prions. Increasing heat-shock protein 40 chaperone activity before Rnq1-GFP expression, shifted Rnq1-GFP aggregation from the cytosol to the nucleus. Assembly of Rnq1-GFP into benign amyloid-like aggregates was more efficient in the nucleus than cytosol and nuclear accumulation of Rnq1-GFP correlated with reduced toxicity. [RNQ+] prions were found to form stable complexes with Htt-103Q, and nuclear Rnq1-GFP aggregates were capable of sequestering Htt-103Q in the nucleus. On accumulation in the nucleus, conversion of Htt-103Q into SDS-resistant aggregates was dramatically reduced and Htt-103Q toxicity was exacerbated. Alterations in activity of molecular chaperones, the localization of intracellular interaction partners, or both can impact the cellular location of disease proteins. This, in turn, impacts proteotoxicity because the assembly of proteins to a benign state occurs with different efficiencies in the cytosol and nucleus.
Additional file 2 of Relationship between craniofacial skeletal patterns and anatomic characteristics of masticatory muscles: a systematic review and meta-analysis
Creators: name: Togninalli, David
name: Antonarakis, Gregory S.
name: Papadopoulou, Alexandra K.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file2 (DOCX 464 KB)
(401598) Annie Crow
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Am I going to Heaven? First step climbing the Stairway to Heaven Model: Results from a Case Study in Industry
Creators: name: Santos Jr, Paulo Sérgio
name: Barcellos, Monalessa P.
name: Calhau
Publisher: name: Zenodo
Year: 2020
Subjects: Stairway to Heaven
Agile
Systems Theory
GUT Matrix
Ontology

description: Context: Nowadays, software development organizations have adopted agile practices and data-driven software development aiming at competitive advantage. Moving from traditional to agile and datadriven software development requires changes in the organization culture and structure, which may not be easy. Stairway to Heaven Model (StH) describes this evolution path in five stages. Objective: We aimed to investigate howSystems Theory tools, GUT Matrix and reference ontologies can help organizations in the first transition of StH, i.e., moving from traditional to agile development. Method: We performed a participative case study in a Brazilian organization that develops software in partnership with a European organization. We applied Systems Theory tools (systemic maps and archetypes) to understand the organization and identify undesirable behaviors and their causes, and also GUT matrices to decide about which ones should be addressed first; we defined strategies to change the undesirable behaviors by implementing agile practices, and we used reference ontologies to share a common understanding about agile concepts. Results: By understanding the organization, a decision was made to implement a combination of agile and traditional practices. The implemented strategies improved software quality and project time and cost. Problems due to misunderstanding agile concepts were solved, allowing the organization to experience agile culture and foresee changes in its business model. Conclusion: Systems Theory tools and GUT Matrix aid organizations to move from traditional to agile development by supporting better understand the organization, find leverage points of change and enabling to define strategies aligned to the organization characteristics and priorities. Reference ontologies can be useful to establish a common understanding about agile, enabling teams to be aware of and, thus, more committed to agile practices and concepts.
Teresa Invrea Paveri Fontana (†1813) / Davide Fiorino, Daniele Vergari
Creators: name: Vergari Daniele
name: Davide, Fiorino
Publisher: name: Zenodo
Year: 2022
Subjects: Accademia dei Georgofili
Invrea Paveri Fontana, Teresa
Fiorino, Davide
Vergari, Daniele
Donne
Scienziate
Pregiudizi
Biografie

description: Testo originale della Mostra virtuale Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911) Natura: risorsa elettronica Consistenza: [4] p. Incipit: La prima accademica dei Georgofili risulta essere la Marchesa Teresa Invrea Paveri Fontana del Dipartimento del Taro, nominata socio Corrispondente il 29 gennaio 1812. Le notizie biografiche sulla nobildonna parmense sono scarse e, per una omonimia, è facile scambiarla con Teresa Paveri Fontana (Parma, 5 luglio 1775 – Parma, 30 gennaio 1850), figlia di Demofilo e della prima moglie Enrichetta Malaspina della Bastia, che raggiunse una certa notorietà come dama di corte e cantante lirica agli inizi del XIX secolo...
description: Digitalizzato come parte della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). https://www.georgofili.it/contenuti/riconoscere-il-merito-superare-i-pregiudizi-scienziate-ai-georgofili-1753-1911-mostra-in-rete/11369
Additional file 1 of Relationship between craniofacial skeletal patterns and anatomic characteristics of masticatory muscles: a systematic review and meta-analysis
Creators: name: Togninalli, David
name: Antonarakis, Gregory S.
name: Papadopoulou, Alexandra K.
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file1 (DOCX 1154 KB)
(401599) Charles Edward Crow
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton
Creators: name: Van Itallie, Christina M.
name: Fanning, Alan S.
name: Anderson, James M.
name: Bridges, Arlene
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: ZO-1 binds numerous transmembrane and cytoplasmic proteins and is required for assembly of both adherens and tight junctions, but its role in defining barrier properties of an established tight junction is unknown. We depleted ZO-1 in MDCK cells using siRNA methods and observed specific defects in the barrier for large solutes, even though flux through the small claudin pores was unaffected. This permeability increase was accompanied by morphological alterations and reorganization of apical actin and myosin. The permeability defect, and to a lesser extent morphological changes, could be rescued by reexpression of either full-length ZO-1 or an N-terminal construct containing the PDZ, SH3, and GUK domains. ZO-2 knockdown did not replicate either the permeability or morphological phenotypes seen in the ZO-1 knockdown, suggesting that ZO-1 and -2 are not functionally redundant for these functions. Wild-type and knockdown MDCK cells had differing physiological and morphological responses to pharmacologic interventions targeting myosin activity. Use of the ROCK inhibitor Y27632 or myosin inhibitor blebbistatin increased TER in wild-type cells, whereas ZO-1 knockdown monolayers were either unaffected or changed in the opposite direction; paracellular flux and myosin localization were also differentially affected. These studies are the first direct evidence that ZO-1 limits solute permeability in established tight junctions, perhaps by forming a stabilizing link between the barrier and perijunctional actomyosin.
title: The role of imaging in the detection and management of colorectal carcinoma
Creators: name: Gandileva, Venelina
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Colon
subject: Gastrointestinal tract
subject: CT
subject: CT-Colonography
subject: MR
subject: Contrast agent-intravenous
subject: Contrast agent-oral
subject: Education
subject: Cancer
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe the imaging characteristics of colorectal carcinoma, its metastases, and the most common complications. To discuss the proper reporting in...
Intake of Supplemental Deer Pellets Containing Ground Blueberry Juniper  by Wild Pigs
Creators: name: Glasscock, Jessica L.
name: Whitney, Travis R
name: Hewitt, David G.
name: Cooper, Susan M
name: Bryant, Fred C.
name: Toenjes, Christina M
Publisher: name: Utah State University
Year: 2020

description: Supplemental feeding of cervid species such as white-tailed deer (Odocoileus virginianus; deer) is now a common management practice in the United States. Supplemental feeding can be costly and more expensive when supplements are consumed by non-target species such as wild pigs (Sus scrofa; pigs). From May 13 to June 17, 2015, we evaluated the effects of using ground blueberry juniper (Juniperus ashei) or cottonseed (Gossypium spp.) hulls as a roughage ingredient in a supplemental deer pellet to deter pig consumption at the Texas A&M AgriLife Research Center in San Angelo, Texas, USA. We analyzed dry matter intake, growth performance, in vitro digestibility and fermentation, and blood serum chemistry of pigs using a 2 × 2 factorial study design that included 3 feeding periods. Pigs were assigned to 1 of 4 supplement diets (n = 5 pigs/supplement) or to a commercially available swine diet (BASAL; n = 4 pigs). Animals assigned to supplement diets were also offered BASAL based on percentage of body weight (BW) during each period. Supplement diets differed by roughage source and percentage of roughage: cottonseed hulls 20%, cottonseed hulls 40%, blueberry juniper 20%, or blueberry juniper 40%. During each period, the amount of supplement and BASAL diet offered to animals assigned to a supplement was fed as a percentage of BW; period 1 (day 0 to 17) = 5% supplement diet and 5% BASAL diet, period 2 (day 18 to 26) = 5% supplement diet and 2% BASAL diet, period 3 (day 27 to 34) = 5% supplement diet and 5% BASAL diet. Animals assigned to only BASAL were offered the same amount of feed as a percent of BW as supplement animals during each period. We observed a roughage × period interaction (P = 0.03) for supplement dry matter intake g/day and a roughage × period interaction (P < 0.09) for total dry matter intake as a percentage of BW. No differences were observed within period. No other variables had percent roughage x period differences. Ground blueberry juniper was indigestible by pigs; the in vitro digestibility of dry matter and gross energy was < 1%. Greater blood serum alanine aminotransferase (P= 0.07) in pigs consuming experimental supplement diets suggested the possibility of liver damage. Our findings suggest that there does not appear to be a benefit of using ground juniper as a roughage source to reduce consumption of supplemental deer feed by pigs.
Cell Type-dependent Requirement for PIP Box-regulated Cdt1 Destruction During S Phase
Creators: name: Xiong, Yue
name: Duronio, Robert J.
name: Lee, Hyun O.
name: Zacharek, Sima J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Previous studies have shown that Cdt1 overexpression in cultured cells can trigger re-replication, but not whether CRL4Cdt2-triggered destruction of Cdt1 is required for normal mitotic cell cycle progression in vivo. We demonstrate that PIP box–mediated destruction of Cdt1Dup during S phase is necessary for the cell division cycle in Drosophila.DNA synthesis–coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4Cdt2 E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase. To directly test whether CRL4Cdt2-triggered destruction of Cdt1 is required for normal cell cycle progression in vivo, we expressed a mutant version of Drosophila Cdt1 (Dup), which lacks the PCNA-binding PIP box (DupΔPIP) and which cannot be regulated by CRL4Cdt2. DupΔPIP is inappropriately stabilized during S phase and causes developmental defects when ectopically expressed. DupΔPIP restores DNA synthesis to dup null mutant embryonic epidermal cells, but S phase is abnormal, and these cells do not progress into mitosis. In contrast, DupΔPIP accumulation during S phase did not adversely affect progression through follicle cell endocycles in the ovary. In this tissue the combination of DupΔPIP expression and a 50% reduction in Geminin gene dose resulted in egg chamber degeneration. We could not detect Dup hyperaccumulation using mutations in the CRL4Cdt2 components Cul4 and Ddb1, likely because these cause pleiotropic effects that block cell proliferation. These data indicate that PIP box–mediated destruction of Dup is necessary for the cell division cycle and suggest that Geminin inhibition can restrain DupΔPIP activity in some endocycling cell types.
Endogenous RhoG Is Rapidly Activated after Epidermal Growth Factor Stimulation through Multiple Guanine-Nucleotide Exchange Factors
Creators: name: Hahn, Klaus M.
name: Monaghan-Benson, Elizabeth
name: Burridge, Keith
name: Samson, Thomas
name: Welch, Christopher
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In this article it is shown that EGF stimulation leads to rapid activation of RhoG through Vav GEFs and the GEF PLEKHG6. Importantly, different cellular responses induced by EGF are determined by the available GEFs. Furthermore, this article presents results showing that EGF-stimulated cell migration and EGFR internalization are regulated by RhoG.RhoG is a member of the Rac-like subgroup of Rho GTPases and has been linked to a variety of different cellular functions. Nevertheless, many aspects of RhoG upstream and downstream signaling remain unclear; in particular, few extracellular stimuli that modulate RhoG activity have been identified. Here, we describe that stimulation of epithelial cells with epidermal growth factor leads to strong and rapid activation of RhoG. Importantly, this rapid activation was not observed with other growth factors tested. The kinetics of RhoG activation after epidermal growth factor (EGF) stimulation parallel the previously described Rac1 activation. However, we show that both GTPases are activated independently of one another. Kinase inhibition studies indicate that the rapid activation of RhoG and Rac1 after EGF treatment requires the activity of the EGF receptor kinase, but neither phosphatidylinositol 3-kinase nor Src kinases. By using nucleotide-free RhoG pull-down assays and small interfering RNA-mediated knockdown studies, we further show that guanine-nucleotide exchange factors (GEFs) of the Vav family mediate EGF-induced rapid activation of RhoG. In addition, we found that in certain cell types the recently described RhoG GEF PLEKHG6 can also contribute to the rapid activation of RhoG after EGF stimulation. Finally, we present results that show that RhoG has functions in EGF-stimulated cell migration and in regulating EGF receptor internalization.
Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911) : [introduzione alla Mostra] / Davide Fiorino, Daniele Vergari
Creators: name: Vergari, Daniele
name: Fiorino, Davide
Publisher: name: Zenodo
Year: 2022
Subjects: Accademia dei Georgofili
Fiorino, Davide
Vergari, Daniele
Scienziate
Pregiudizi
Donne

description: Introduzione alla mostra virtuale Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). Natura: risorsa elettronica. Consistenza: [5] p. Abstract: Affrontare il tema della partecipazione femminile alla vita dell’Accademia dei Georgofili nel corso dei suoi primi 150 anni di vita non vuole essere un tentativo di ricostruzione di storia di genere, per la quale non abbiamo gli strumenti, ma vuole essere un tassello di una ricostruzione delle vicende dell’Istituzione attraverso i suoi soci, che superi ed integri studi già esistenti ed editi dall’Accademia. Dal lavoro di Marco Tabarrini a quelli celebrativi di Tito Marucelli e Nino Breviglieri, rispettivamente per il centesimo, centocinquantesimo e per il duecentesimo anniversario dalla sua istituzione, l’Accademia non ha mai fatto una riflessione sulle figure femminili che sono state accolte nell’Accademia in passato. Il recupero dei registri manoscritti relativi agli accademici corrispondenti nel periodo fra la fondazione e il 1864 ha permesso così di far ri-emergere alcune accademiche di cui si era persa, in qualche modo, memoria e ri-scoprirne il valore scientifico....
description: Realizzato come parte della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). https://www.georgofili.it/contenuti/riconoscere-il-merito-superare-i-pregiudizi-scienziate-ai-georgofili-1753-1911-mostra-in-rete/11369
Spatial and Temporal Dynamics of Human–Wildlife Conflicts in the Kenya Greater Tsavo Ecosystem
Creators: name: Mukeka, Joseph M.
name: Ogutu, Joseph O.
name: Kanga, Erustus
name: Røskaft, Eivin
Publisher: name: Utah State University
Year: 2020

description: Biodiversity conservation in developing countries is faced with many and mounting challenges, including increasing human–wildlife conflicts (HWCs). In Africa and other developing countries, increasing HWCs, particularly those adjacent to protected areas, can adversely affect local stakeholder perceptions and support for conservation. We analyzed HWC reports for multiple wildlife species compiled >23 years (1995–2017) from the Greater Tsavo Ecosystem (GTE) in Kenya to determine HWC trends. The GTE is the largest protected area in Kenya, covering 22,681 km2. Overall, 39,022 HWC incidents were reported in 6 GTE regions (i.e., Taveta, Mutomo, Kibwezi, Rombo, Galana, Bachuma). The 5 wildlife species most often implicated in HWC incidents were the African elephant (Loxodonta africana, 61.6%, n = 24,032), nonhuman primates (11.5%, n = 4,480), buffalo (Syncerus caffer, 6.2%, n = 2,432 ), African lion (Panthera leo, 4.2%, n = 1,645), and the hippopotamus (Hippopotamus amphibius, 3.8%, n = 1,497). The HWC reports also revealed spatial distinctions across the 6 GTE regions. More human–elephant conflicts (HECs; 43.3%, n = 10,427) were reported in the Taveta region than other regions. The Mutomo region was the epicenter of primate, snake, and python (Python spp.) conflicts. More large carnivore depredations on livestock were reported in the Taveta, Rombo, and Mutomo regions. Lions, spotted hyenas (Crocuta crocuta), and leopards (P. pardus) were implicated in more livestock depredations than other carnivores. The number of HWCs reported varied by year and season and were related to similar variations in the availability, quality, and distribution of food and water governed by rainfall fluctuations. Reported HECs were positively and linearly related to human, elephant, and livestock population densities. The Kenya Wildlife Service responded to >90% of the reported HWCs. In general, the number of HWCs and trends reported were higher in the regions that also exhibited the highest human population growth rates and densities. Sustainable biodiversity conservation in human-dominated landscapes is contingent upon communities deriving meaningful benefits from wildlife conservation. Far-sighted measures and different conservation approaches are required to mitigate HWCs in communities neighboring protected areas.
title: Imaging of congenital lung malformations about 20 cases: from antenatal to postnatal diagnosis
Creators: name: ELmouden, hanane
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Paediatric
subject: Thorax
subject: CT
subject: Ultrasound
subject: Complications
subject: Cysts

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Congenital lung malformations (CLMs) are rare and constitute a very diversified group of anomalies related to the development of the tracheobronchial tree. [6] The prenatal growth pattern of CLMs is unpredictable with larger lesions causing...
Entanglement of quantum clocks through gravity
Creators: name: Castro-Ruiz, Esteban
name: Giacomini, Flaminia
name: Brukner, Časlav
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In general relativity, the picture of spacetime assigns an ideal clock to each worldline. Being ideal, gravitational effects due to these clocks are ignored and the flow of time according to one clock is not affected by the presence of clocks along nearby worldlines. However, if time is defined operationally, as a pointer position of a physical clock that obeys the principles of general relativity and quantum mechanics, such a picture is at most a convenient fiction. Specifically, we show that the general relativistic mass-energy equivalence implies gravitational interaction between the clocks, while the quantum mechanical superposition of energy eigenstates leads to a non-fixed metric background. Based only on the assumption that both principles hold in this situation, we show that the clocks necessarily get entangled through time dilation effect, which eventually leads to a loss of coherence of a single clock. Hence, the time as measured by a single clock is not well-defined. However, the general relativistic notion of time is recovered in the classical limit of clocks.
description: 14 pages, 3 figures. Revised version, contains a new figure and further derivations. Published version, doi: 10.1073/pnas.1616427114
(401594) Alexander Hutcheson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Fast Microtubule Dynamics in Meiotic Spindles Measured by Single Molecule Imaging: Evidence That the Spindle Environment Does Not Stabilize Microtubules
Creators: name: Maresca, Tom
name: Ohi, Ryoma
name: Mitchison, Tim
name: Needleman, Daniel J.
name: Groen, Aaron
name: Mirny, Leonid
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Metaphase spindles are steady-state ensembles of microtubules. We used single molecule imaging to measure tubulin dynamics in spindles and non-spindle assemblies in Xenopus egg extract. Our results argue that the high density of microtubules in spindles is caused by local enhancement of nucleation, and not by local stabilization.Metaphase spindles are steady-state ensembles of microtubules that turn over rapidly and slide poleward in some systems. Since the discovery of dynamic instability in the mid-1980s, models for spindle morphogenesis have proposed that microtubules are stabilized by the spindle environment. We used single molecule imaging to measure tubulin turnover in spindles, and nonspindle assemblies, in Xenopus laevis egg extracts. We observed many events where tubulin molecules spend only a few seconds in polymer and thus are difficult to reconcile with standard models of polymerization dynamics. Our data can be quantitatively explained by a simple, phenomenological model—with only one adjustable parameter—in which the growing and shrinking of microtubule ends is approximated as a biased random walk. Microtubule turnover kinetics did not vary with position in the spindle and were the same in spindles and nonspindle ensembles nucleated by Tetrahymena pellicles. These results argue that the high density of microtubules in spindles compared with bulk cytoplasm is caused by local enhancement of nucleation and not by local stabilization. It follows that the key to understanding spindle morphogenesis will be to elucidate how nucleation is spatially controlled.
Indigenous Guardianship and Moose Monitoring: Weaving Indigenous and Western Ways of Knowing
Creators: name: Popp, Jesse N
name: Priadka, Pauline
name: Young, Megan
name: Koch, Kevin
name: Morgan, James
Publisher: name: Utah State University
Year: 2020

description: Increasing global rates of wildlife species extinctions, extirpations, and declines warrant improvements to population monitoring and management approaches. To address regional environmental and wildlife issues, Indigenous communities globally are re-establishing traditional roles as stewards of the land through emerging Indigenous Guardianship Programs (IGPs). By providing the opportunity for community-level participation in monitoring and management, IGPs help foster cohesive solutions for long-term conservation of species while promoting environmental stewardship at the community level. Addressing challenges in monitoring and management of wildlife is especially critical for species that are of cultural and ecological importance at both community and distribution-wide scales. Herein, we describe IGPs in Canada with a focus on moose (Alces alces), an important species to many Indigenous Peoples across the species’ distribution. We outline common Western approaches to moose monitoring applied across Canadian jurisdictions and discuss ways in which weaving Indigenous knowledge systems and information gathered through local participation from Indigenous communities enhances monitoring initiatives at regional levels. We elaborate on a case study on moose monitoring and co-management in the community of Gitanyow in British Columbia, Canada to highlight the value of Guardianship to communities and species conservation in relation to moose. Our study reveals how IGPs and the weaving of Indigenous and Western knowledge systems can contribute to the maintenance of both ecological and cultural integrity to strengthen wildlife monitoring and management under changing global environments.
ТУКИМАЧИЛИК МАХСУЛОТЛАРИ БОЗОРИДА РАКОБАТ МУХИТИНИ ТАҲЛИЛ ҚИЛИШ АСОСЛАРИ.
Creators: name: Джуманиязова, М.
Publisher: name: Zenodo
Year: 2023

description: Мақолада тукимачилик корхоналарида рақобатбардошлигини ошириш омиллари ва шароитларини аниқлаш ҳамда уларни дастурий ҳужжатларда акс эттириш билан боғлиқ назарий, услубий муаммолар баён этилган.
An analogue of a van der Waerden's theorem and its application to two-distance preserving mappings
Creators: name: Alexandrov, Victor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 52B11, 52B70, 52C25, 51K05

description: The van der Waerden's theorem reads that an equilateral pentagon in Euclidean 3-space $\Bbb E^3$ with all diagonals of the same length is necessarily planar and its vertex set coincides with the vertex set of some convex regular pentagon. We prove the following many-dimensional analogue of this theorem: for $n\geqslant 2$, every $n$-dimensional cross-polytope in $\Bbb E^{2n-2}$ with all diagonals of the same length and all edges of the same length necessarily lies in $\Bbb E^n$ and hence is a convex regular cross-polytope. We also apply our theorem to the study of two-distance preserving mappings of Euclidean spaces.
description: 6 pages; in version 2, a typo is corrected in the abstract
When Pigs Virtually Fly
Creators: name: Tegt, Jessica L.
Publisher: name: Utah State University
Year: 2020

description: Planning for the 2020 Wild Pig Conference was well underway until March 10, 2020, when word was received that federal travel was placed on indefinite hiatus due to COVID-19. The National Wild Pig Task Force leadership and conference organizers took immediate action to cancel the conference and then later announced they would host the first totally virtual wildlife management conference. This Back Page article describes the shift to a fully virtual conference.
Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase
Creators: name: Brenman, Jay E.
name: Kazgan, Nevzat
name: Forsberg, Lawrence J.
name: Williams, Tyisha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In this study, we utilized genetic and cell biological approaches to evaluate potential functions for the AMPKα C-terminus. We identify a critical new function for the carboxy-terminal amino acids of AMPKα in vivo, which affects AMPKα subcellular localization, phosphorylation, and ultimately organismal viability.The metabolic regulator AMP-activated protein kinase (AMPK) maintains cellular homeostasis through regulation of proteins involved in energy-producing and -consuming pathways. Although AMPK phosphorylation targets include cytoplasmic and nuclear proteins, the precise mechanisms that regulate AMPK localization, and thus its access to these substrates, are unclear. We identify highly conserved carboxy-terminal hydrophobic amino acids that function as a leptomycin B–sensitive, CRM1-dependent nuclear export sequence (NES) in the AMPK catalytic subunit (AMPKα). When this sequence is modified AMPKα shows increased nuclear localization via a Ran-dependent import pathway. Cytoplasmic localization can be restored by substituting well-defined snurportin-1 or protein kinase A inhibitor (PKIA) CRM1-binding NESs into AMPKα. We demonstrate a functional requirement in vivo for the AMPKα carboxy-terminal NES, as transgenic Drosophila expressing AMPKα lacking this NES fail to rescue lethality of AMPKα null mutant flies and show decreased activation loop phosphorylation under heat-shock stress. Sequestered to the nucleus, this truncated protein shows highly reduced phosphorylation at the key Thr172 activation residue, suggesting that AMPK activation predominantly occurs in the cytoplasm under unstressed conditions. Thus, modulation of CRM1-mediated export of AMPKα via its C-terminal NES provides an additional mechanism for cells to use in the regulation of AMPK activity and localization.
title: Trainee's guide for IgG4 related pancreatitis.
Creators: name: Arora, Dhawal
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Anatomy
subject: MR
subject: MR-Cholangiography
subject: Diagnostic procedure
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To illustrate the imaging features of IgG4 pancreatitis Role of imaging post treatment of...
(401596) James Watson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Eagle’s syndrome: the role of radiologist.
Creators: name: vasile, tiziana
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Bones
subject: Head and neck
subject: Conventional radiography
subject: CT
subject: Ultrasound-Colour Doppler
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Eagle’s syndrome is a rare condition caused by an elongated styloid process and/or calcification of the stylohyoid ligament. This study aims to define and describe Eagle’s syndrome and its radiological features, helping physicians in...
Scaling and superscaling solutions from the functional renormalization group
Creators: name: Hellwig, Tobias
name: Wipf, Andreas
name: Zanusso, Omar
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the renormalization group flow of $\mathbb{Z}_2$-invariant supersymmetric and non-supersymmetric scalar models in the local potential approximation using functional renormalization group methods. We focus our attention to the fixed points of the renormalization group flow of these models, which emerge as scaling solutions. In two dimensions these solutions are interpreted as the minimal (supersymmetric) models of conformal field theory, while in three dimension they are manifestations of the Wilson-Fisher universality class and its supersymmetric counterpart. We also study the analytically continued flow in fractal dimensions between 2 and 4 and determine the critical dimensions for which irrelevant operators become relevant and change the universality class of the scaling solution. We also include novel analytic and numerical investigations of the properties that determine the occurrence of the scaling solutions within the method. For each solution we offer new techniques to compute the spectrum of the deformations and obtain the corresponding critical exponents.
description: 23 pages, 14 figures; v2: several improvements, new references, version to appear in PRD
title: Are some school inspectors more lenient than others?
Creators: name: Bokhove, Christian
name: Jerrim, John
name: Sims, Samuel
Publisher: name: University of Southampton
Year: 2023

description: School inspections are a common feature of education systems across the word. These involve trained professionals visiting schools and reaching a high-stakes judgement about the quality of education they provide. By their nature, school inspections rely upon professional judgement, with different inspectors potentially putting more emphasis on certain areas than others. Yet there is currently little academic evidence investigating the consistency of school inspections, including how judgements vary across inspectors with different characteristics. We present new empirical evidence on this matter, drawing upon data from more than 30,000 school inspections conducted in England between 2011 and 2019. Male inspectors are found to award slightly more lenient judgements to primary schools than their female counterparts, while permanent Ofsted employees (Her Majesty's Inspectors) are found to be harsher than those who inspect schools on a freelance basis (Ofsted Inspectors).
(401592) Thomas Kinnear Wright
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The Role of Percutaneous Cholecystostomy in the Treatment of Acute Cholecystitis
Creators: name: Arık, Erbil
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Biliary Tract / Gallbladder
subject: Interventional vascular
subject: Fluoroscopy
subject: Ultrasound
subject: Catheters
subject: Drainage
subject: Laboratory tests
subject: Acute
subject: Infection
subject: Inflammation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Percutaneous cholecystostomy (PC) is, by definition, the placement of a catheter into the gallbladder (GB) lumen under imaging guidance [1]. It is applied in patients with the diagnosis of acute calculous or acalculous cholecystitis who are in...
Collapsing democracy in the 21st century : the case of Myanmar
Creators: name: Padrón Hernández, Eduardo
Publisher: name: My University
Year: 2022
Subjects: democracy
democratisation
Myanmar
case studies

description: Second semester University: University of Zagreb
description: The Myanmar military, or Tatmadaw, put an end to the country’s democratic experience on the 1st of February 2021 staging a coup d’etat. This event closed a decade of allegedly inadequate democratic reforms in the hopes of the western democracies in South-East Asia after their failed interventionism in Iraq and Afghanistan. Ironically, the Tatmadaw promoted the beginning of the democratisation process post-2010. Aiming at analysing the reasoning behind why military elites decide to modernise the political institutions of a country, this paper explores the relations between the Tatmadaw and the civilian pro-democratic movement during the last decade in Myanmar. Meanwhile, the world democracies experience new challenges in the nature of their polity and struggle to defend the principles of the right mode of governance since the end of the Cold War.
The Exo70 Subunit of the Exocyst Is an Effector for Both Cdc42 and Rho3 Function in Polarized Exocytosis
Creators: name: Brennwald, Patrick
name: Gardner, Jimmy
name: Wu, Hao
name: Temple, Brenda
name: Turner, Courtney
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Genetic and biochemical evidence is presented that the Exo70 subunit of the exocyst is a direct effector for both Rho3 and Cdc42 GTPases in yeast. Prenylation of these GTPases both promotes the interaction and affects the site of binding within Exo70. Thus, interaction of the Rho GTPases with Exo70 is a key event in spatial regulation of exocytosis.The Rho3 and Cdc42 members of the Rho GTPase family are important regulators of exocytosis in yeast. However, the precise mechanism by which they regulate this process is controversial. Here, we present evidence that the Exo70 component of the exocyst complex is a direct effector of both Rho3 and Cdc42. We identify gain-of-function mutants in EXO70 that potently suppress mutants in RHO3 and CDC42 defective for exocytic function. We show that Exo70 has the biochemical properties expected of a direct effector for both Rho3 and Cdc42. Surprisingly, we find that C-terminal prenylation of these GTPases both promotes the interaction and influences the sites of binding within Exo70. Finally, we demonstrate that the phenotypes associated with novel loss-of-function mutants in EXO70, are entirely consistent with Exo70 as an effector for both Rho3 and Cdc42 function in secretion. These data suggest that interaction with the Exo70 component of the exocyst is a key event in spatial regulation of exocytosis by Rho GTPases.
Component action of nilpotent multiplet coupled to matter in 4 dimensional ${\cal N}=1$ supergravity
Creators: name: Hasegawa, Fuminori
name: Yamada, Yusuke
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We construct the component action of the system including an ordinary matter and a nilpotent multiplet in global and local supersymmetric framework. The higher dimensional operators of not only Goldstino but also matter and gravitino fields are shown, which appear due to nonlinearly realized supersymmetry.
description: 15pages, v2:references added, and typos corrected, v3:typos corrected, v4:typos corrected
The Spectraplakin Short Stop Is an Actin-Microtubule Cross-Linker That Contributes to Organization of the Microtubule Network
Creators: name: Rogers, Stephen L.
name: Applewhite, Derek A.
name: Zadeh, Alireza
name: Keller, Darby
name: Grode, Kyle D.
name: Slep, Kevin C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The dynamics of actin and microtubules are coordinated in a variety of cellular and morphogenetic processes; however, little is known about the molecules mediating this cytoskeletal cross-talk. We are studying Short stop (Shot), the sole Drosophila spectraplakin, as a model actin–microtubule cross-linking protein. Spectraplakins are an ancient family of giant cytoskeletal proteins that are essential for a diverse set of cellular functions; yet, we know little about the dynamics of spectraplakins and how they bridge actin filaments and microtubules. In this study we describe the intracellular dynamics of Shot and a structure–function analysis of its role as a cytoskeletal cross-linker. We find that Shot interacts with microtubules using two different mechanisms. In the cell interior, Shot binds growing plus ends through an interaction with EB1. In the cell periphery, Shot associates with the microtubule lattice via its GAS2 domain, and this pool of Shot is actively engaged as a cross-linker via its NH2-terminal actin-binding calponin homology domains. This cross-linking maintains microtubule organization by resisting forces that produce lateral microtubule movements in the cytoplasm. Our results provide the first description of the dynamics of these important proteins and provide key insight about how they function during cytoskeletal cross-talk.
Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins
Creators: name: Theodoraki, Maria A.
name: Sultana, Rasheda
name: Mandal, Atin K.
name: Mayo, Katie J.
name: Ren, Hong Yu
name: Cyr, Douglas M.
name: Johnson, Jill
name: Nillegoda, Nadinath B.
name: Caplan, Avrom J.
name: Wu, Kenneth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Ubr1 and Ubr2 ubiquitin ligases are shown to promote degradation of misfolded cytosolic polypeptides in vivo and in a purified system in association with Hsp70.Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr2 ubiquitin ligases promote degradation of unfolded or misfolded cytosolic polypeptides. Ubr1 also catalyzes ubiquitinylation of denatured but not native luciferase in a purified system. This activity is based on the direct interaction of denatured luciferase with Ubr1, although Hsp70 stimulates polyubiquitinylation of the denatured substrate. We also report that loss of Ubr1 and Ubr2 function suppressed the growth arrest phenotype resulting from chaperone mutation. This correlates with increased protein kinase maturation and indicates partitioning of foldable conformers toward the proteasome. Our findings, based on the efficiency of this quality control system, suggest that the cell trades growth potential to avert the potential toxicity associated with accumulation of unfolded or misfolded proteins. Ubr1 and Ubr2 therefore represent E3 components of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
title: Significance of MRI in the diagnosis and differentiation of placental abnormalities
Creators: name: Videva, Desislava
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: MR
subject: Diagnostic procedure
subject: Haemorrhage
subject: Obstetrics

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: to present and illustrate the diverse array of placental abnormalities and their specific radiological characteristics; to outline the clinical cases in which MRI could be more useful than ultrasound and therefore of utmost importance for the...