cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Methodological details, supplementary figures, and tables from Domestication impacts on plant-herbivore interactions: a meta-analysis
Creators: name: Whitehead, Susan R.
name: Turcotte, Martin M.
name: Poveda, Katja
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Plant Biology

description: For millennia, humans have imposed strong selection on domesticated crops, resulting in drastically altered crop phenotypes compared with wild ancestors. Crop yields have increased, but a long-held hypothesis is that domestication has also unintentionally decreased plant defences against herbivores. To test this hypothesis, we conducted a phylogenetically controlled meta-analysis comparing insect herbivore resistance and putative plant defence traits between crops and their wild relatives. Our database included 2098 comparisons made across 73 crops in 89 studies. We found that domestication consistently reduced plant resistance to herbivores, although the magnitude of the effects varied across plant organs and depending on how resistance was measured. However, domestication had no consistent effects on the specific plant defence traits underlying resistance, including secondary metabolites and physical feeding barriers. The values of these traits sometimes increased and sometimes decreased during domestication. Consistent negative effects of domestication were observed only when defence traits were measured in reproductive organs or in the plant organ that was harvested. These results highlight the complexity of evolution under domestication and the need for an improved theoretical understanding of the mechanisms through which agronomic selection can influence the species interactions that impact both the yield and sustainability of our food systems.This article is part of the themed issue 'Human influences on evolution, and the ecological and societal consequences'.
Identification of the energy contributions associated with wall-attached eddies and very-large-scale motions in the near-neutral atmospheric surface layer through wind LiDAR measurements
Creators: name: Puccioni, Matteo
name: Calaf, Marc
name: Pardyjak, Eric R.
name: Hoch, Sebastian
name: Morrison, Travis J.
name: Perelet, Alexei
name: Iungo, Giacomo Valerio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Recent works on wall-bounded flows have corroborated the coexistence of wall-attached eddies, whose statistical features are predicted through Townsend's attached eddy hypothesis (AEH), and very-large-scale motions (VLSMs), which are not encompassed in the AEH. Furthermore, it has been shown that the presence of wall-attached eddies within the logarithmic layer is linked to the appearance of an inverse-power-law region in the streamwise velocity energy spectra, upon significant separation between outer and viscous scales. In this work, a near-neutral atmospheric surface layer (ASL) is probed with a wind LiDAR to investigate the contributions to the streamwise velocity energy associated with wall-attached and VLSMs for a very-high Reynolds-number boundary layer. Energy and linear coherence spectra (LCS) of the streamwise velocity are interrogated to identify the spectral boundaries associated with eddies of different typologies and the maximum height attained by wall-attached eddies. Inspired by the AEH, an analytical model for the LCS associated with wall-attached eddies is formulated. The experimental results show that the identification of the wall-attached-eddy energy contribution through the analysis of the energy spectra leads to an underestimate of the associated spectral range, maximum height attained, and turbulence intensity. This feature is due to the overlap of the energy associated with VLSMs obscuring the inverse-power-law region. On the other hand, the Townsend-Perry constant for the turbulence intensity seems to be properly estimated through the spectral analysis. The LCS analysis estimates wall-attached eddies with a streamwise/wall-normal ratio of about 14.3 attaining a height of about 30% of the outer scale of turbulence.
{pdf descargar} EL SASTRE DE PANAMA
Creators: name: Honeycutt
Publisher: name: Zenodo
Year: 2024

description: EL SASTRE DE PANAMA de JOHN LE CARRE

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EL SASTRE DE PANAMA

JOHN LE CARRE

Número de páginas: 544

Idioma: CATALÁN

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788429751604

Editorial: EDICIONS 62

Año de edición: 2002

 

 

 

 

 

Ebook francais descargar gratuit EL SASTRE DE PANAMA

 

Overview

Harry Pendel, un prestigiós sastre anglès resident al Panamà, és triat com a agent pel servei d'espionatge britànic. A dos anys de recuperar el control sobre el canal, Panamà és un cau de droga, de diner blanquejat i de corrupció. Pendel escolta plans i confidències dels seus clients: des del president panameny fins a un general nord-americà, passant per polítics, lladres i tota mena d'estafadors. I la informació que li falta l'acabarà sabent per altres bandes. En aquesta sàtira del nostre temps, Le Carré es qüestiona: iquè són els espies, els polítics i els periodistes, sinó seleccionadors i manipuladors de la veritat segons les seves conveniències?
S1.mp4 from Dynamics and flight control of a flapping-wing robotic insect in the presence of wind gusts..
Creators: name: Pakpong Chirarattananon
name: Yufeng Chen
name: E. Farrell Helbling
name: Ma, Kevin Y.
name: Cheng, Richard
name: Wood, Robert J.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Biological Engineering
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Electronic supplementary video
Contributions to the Muon $g-2$ from a Three-Form Field
Creators: name: Huang, Da
name: Tang, Yong
name: Wu, Yue-Liang
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We examine contributions to the muon dipole moment $g-2$ from a 3-form field $Ω$, which naturally arises from many fundamental theories, such as the string theory and the hyperunified field theory. In particular, by calculating the one-loop Feynman diagram, we have obtained the leading-order $Ω$-induced contribution to the muon $g-2$, which is found to be finite. Then we investigate the theoretical constraints from perturbativity and unitarity. Especially, the unitarity bounds are yielded by computing the tree-level $μ^+μ^-$ scattering amplitudes of various initial and final helicity configurations. As a result, despite the strong unitarity bounds imposed on this model of $Ω$, we have still found a substantial parameter space which can accommodates the muon $g-2$ data.
description: 21 pages, 3 figures; references added
Geodesic equation in Schwarzschild--(anti-)de Sitter space--times: Analytical solutions and applications
Creators: name: Hackmann, Eva
name: Lämmerzahl, Claus
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The complete set of analytic solutions of the geodesic equation in a Schwarzschild--(anti-)de Sitter space--time is presented. The solutions are derived from the Jacobi inversion problem restricted to the set of zeros of the theta function, called the theta divisor. In its final form the solutions can be expressed in terms of derivatives of Kleinian sigma functions. The different types of the resulting orbits are characterized in terms of the conserved energy and angular momentum as well as the cosmological constant. Using the analytical solution, the question whether the cosmological constant could be a cause of the Pioneer Anomaly is addressed. The periastron shift and its post--Schwarzschild limit is derived. The developed method can also be applied to the geodesic equation in higher dimensional Schwarzschild space--times.
description: 23 pages, 12 figures
Read online: Augmented Reality: Principles and Practice by Dieter Schmalstieg, Tobias Hollerer
Creators: name: Exley
Publisher: name: Zenodo
Year: 2024

description: Augmented Reality: Principles and Practice by Dieter Schmalstieg, Tobias Hollerer

 

 

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Augmented Reality: Principles and Practice

Dieter Schmalstieg, Tobias Hollerer

Page: 552

Format: pdf, ePub, mobi, fb2

ISBN: 9780321883575

Publisher: Addison-Wesley

 

Free new release books download Augmented Reality: Principles and Practice ePub iBook FB2 in English 9780321883575

Overview

Augmented Reality (AR) is one of today's most fascinating and future-oriented areas of computer science and technology. By overlaying computer-generated information on views of the real world, AR amplifies human perception and cognition in remarkable new ways. Do you like the virtual first-down line in football games on TV? That's AR -- and AR apps are rapidly coming to billions of smartphones, too. Working in AR requires knowledge from diverse disciplines, including computer vision, computer graphics, and human-computer interaction (HCI). Augmented Reality: Principles and Practice integrates all this knowledge into one single-source reference, presenting the most significant AR work with scrupulous accuracy. Dieter Schmalstieg, a pioneer of both AR foundation and application, is drawing from his two decades of AR experience to clearly present the field. Together with mobile AR pioneer and research colleague Tobias Höllerer he addresses all aspects of the field, illuminating AR from both technical and HCI perspectives. The authors review AR's technical foundations, including display and tracking technologies, show how AR emerges from the symbiosis of computer vision and computer graphics, introduce AR-specific visualization and 3D interaction techniques, and showcase applications from diverse industries. They conclude with an outlook on trends and emerging technologies, including practical pointers for beginning practitioners. This book will be an indispensable resource for everyone interested in AR, including software and app developers, engineers, students and instructors, researchers, and hobbyists. For use in educational environments, the authors provide a companion website containing slides, code examples, and other source materials/
A Unified Catalog-level Reanalysis of Stage-III Cosmic Shear Surveys
Creators: name: Longley, Emily P.
name: Chang, Chihway
name: Walter, Christopher W.
name: Zuntz, Joe
name: Ishak, Mustapha
name: Mandelbaum, Rachel
name: Miyatake, Hironao
name: Nicola, Andrina
name: Pedersen, Eske M.
name: Pereira, Maria E. S.
name: Prat, Judit
name: Sánchez, J.
name: Tröster, Tilman
name: Troxel, Michael
name: Wright, Angus
name: Collaboration, The LSST Dark Energy Science
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Cosmological parameter constraints from recent galaxy imaging surveys are reaching $2-3\%$-level accuracy. The upcoming Legacy Survey of Space and Time (LSST) of the Vera C. Rubin Observatory will produce sub-percent level measurements of cosmological parameters, providing a milestone test of the $Λ$CDM model. To supply guidance to the upcoming LSST analysis, it is important to understand thoroughly the results from different recent galaxy imaging surveys and assess their consistencies. In this work we perform a unified catalog-level reanalysis of three cosmic shear datasets: the first year data from the Dark Energy Survey (DES-Y1), the 1,000 deg$^{2}$ dataset from the Kilo-Degree Survey (KiDS-1000), and the first year data from the Hyper Suprime-Cam Subaru Strategic Program (HSC-Y1). We utilize a pipeline developed and rigorously tested by the LSST Dark Energy Science Collaboration to perform the reanalysis and assess the robustness of the results to analysis choices. We find the $S_{8}$ constraint to be robust to two different small-scale modeling approaches, and varying choices of cosmological priors. Our unified analysis allows the consistency of the surveys to be rigorously tested and we find the three surveys to be statistically consistent. Due to the partially overlapping footprint, we model the cross-covariance between KiDS-1000 and HSC-Y1 approximately when combining all three datasets, resulting in a $1.6-1.9\%$ constraint on $S_8$ given different assumptions on the cross-covariance.
description: 27 pages, 18 figures, to be submitted to MNRAS
(3043) Harold Norman Tate
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Two Nucleon Systems at $m_π\sim 450~{\rm MeV}$ from Lattice QCD
Creators: name: Orginos, Kostas
name: Parreno, Assumpta
name: Savage, Martin J.
name: Beane, Silas R.
name: Chang, Emmanuel
name: Detmold, William
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Nucleon-nucleon systems are studied with lattice quantum chromodynamics at a pion mass of $m_π\sim 450~{\rm MeV}$ in three spatial volumes using $n_f=2+1$ flavors of light quarks. At the quark masses employed in this work, the deuteron binding energy is calculated to be $B_d = 14.4^{+3.2}_{-2.6} ~{\rm MeV}$, while the dineutron is bound by $B_{nn} = 12.5^{+3.0}_{-5.0}~{\rm MeV}$. Over the range of energies that are studied, the S-wave scattering phase shifts calculated in the 1S0 and 3S1-3D1 channels are found to be similar to those in nature, and indicate repulsive short-range components of the interactions, consistent with phenomenological nucleon-nucleon interactions. In both channels, the phase shifts are determined at three energies that lie within the radius of convergence of the effective range expansion, allowing for constraints to be placed on the inverse scattering lengths and effective ranges. The extracted phase shifts allow for matching to nuclear effective field theories, from which low energy counterterms are extracted and issues of convergence are investigated. As part of the analysis, a detailed investigation of the single hadron sector is performed, enabling a precise determination of the violation of the Gell-Mann--Okubo mass relation. [An Erratum to the published version is included as an appendix. It details the impact of an error discovered in 2020 and corrects typographical errors.]
description: 29 pages, 31 figures, Erratum from 2020 included
Is there publication bias in the reporting of cancer risk in Barrett's esophagus?
Creators: name: Bozymski, E. M.
name: Crosby, M. A.
name: Sandler, R. S.
name: Shaheen, N. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: AbstractBackground & Aims: The published risk of adenocarcinoma in the setting of Barrett's esophagus (BE) varies. Publication bias, the selective reporting of studies featuring positive or extreme results, may result in overestimation of this cancer risk in the literature. The aim of this study was to assess those publications reporting a cancer risk in BE for evidence of publication bias. Methods: A MEDLINE search for all published estimates between 1966 and 1998 of cancer risk in BE was performed. All studies reporting a cancer risk expressible in cancers per patient-year of follow-up were retrieved. Bibliographies of these studies were surveyed for additional estimates. All publications that required an initial endoscopy with histologic confirmation of BE and any cancer were included. The relationship of reported cancer risk to size of the study was assessed. Multivariable regression controlling for differences in definition of BE, as well as other study characteristics, was performed. The data were also analyzed by means of a funnel diagram, an epidemiologic method to assess publication bias. Results: Five hundred fifty-four abstracts were reviewed. Twenty-seven publications met the stated criteria for inclusion. There was a strong correlation between cancer risk and the size of the study, with small studies reporting much higher risks of cancer than larger studies. This association persisted when differences in the definition of BE, retrospective vs. prospective nature of the study, surveillance interval, and the effect of cancer detected in the first year were considered. The funnel diagram analysis suggested publication bias. Conclusions: The cancer risk in BE may be overestimated in the literature due to publication bias.GASTROENTEROLOGY 2000;119:333-338
Non-Linear Ablative Rayleigh-Taylor Instability: Increased Growth due to Self-Generated Magnetic Fields
Creators: name: Walsh, C. A.
name: Clark, D. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The growth rate of the non-linear ablative Rayleigh-Taylor (RT) instability is enhanced by magnetic fields self-generated by the Biermann battery mechanism; a scaling for this effect with perturbation height and wavelength is proposed and validated with extended-magnetohydrodynamic simulations. The magnetic flux generation rate around a single RT spike is found to scale with the spike height. The Hall Parameter, which quantifies electron magnetization, is found to be strongly enhanced for short wavelength spikes due to Nernst compression of the magnetic field at the spike tip. The impact of the magnetic field on spike growth is through both the suppressed thermal conduction into the unstable spike and the Righi-Leduc heat-flow deflecting heat from the spike tip to the base. Righi-Leduc is found to be the dominant effect for small Hall Parameters, while suppressed thermal conduction dominates for large Hall Parameters. These results demonstrate the importance of considering magnetic fields in all perturbed inertial confinement fusion hot-spots.
Tata Kelola Jurnal Internasional Bereputasi
Creators: name: Busro
Publisher: name: Zenodo
Year: 2022

description: TATA Kelola JURNAL INTERNASIONAL BEREPUTASI
 Disampaikan dalam kegiatan Bimtek Tata Kelola E-Jurnal Bereputasi International, UIN Fatmawati Bengkulu,
 07 September 2022
Descargar EL PRIMER CASO DE UNAMUNO
Creators: name: Watson
Publisher: name: Zenodo
Year: 2024

description: EL PRIMER CASO DE UNAMUNO EBOOK de LUIS GARCIA JAMBRINA

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EL PRIMER CASO DE UNAMUNO EBOOK

LUIS GARCIA JAMBRINA

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788420476773

Editorial: ALFAGUARA

Año de edición: 2024

 

 

 

 

 

Descargar el texto completo de los libros. EL PRIMER CASO DE UNAMUNO EBOOK de LUIS GARCIA JAMBRINA en español 9788420476773 MOBI ePub DJVU

 

Overview

MIGUEL DE UNAMUNO ES DETECTIVE EN ESTE FASCINANTE THRILLER HISTÓRICOPor el ganador del Premio Internacional de Novela Histórica por la serie «Fernando de Rojas, pesquisidor», con más de cien mil lectores:«El Sherlock Holmes del Renacimiento» (El Confidencial)En el crudo diciembre de 1905, Enrique Maldonado, propietario de las tierras del municipio salamantino de Boada y cacique local, aparece brutalmente apuñalado en las afueras del pueblo. Los vecinos son los principales sospechosos de haberle dado muerte y Unamuno, que escribió un artículo incendiario para denunciar las condiciones de vida de los campesinos boadenses, decide investigar el crimen con la ayuda de Manuel Rivera, abogado defensor de los detenidos, y Teresa Maragall, una misteriosa anarquista.Conforme vayan apareciendo nuevos cadáveres, el perfil público de Unamuno como intelectual de renombre y polémico rector de la Universidad de Salamanca se verá dividido entre sus valedores y sus detractores, y su carácter indomable se topará con el poder y sus insidias, dificultando las pesquisas y poniendo en peligro muchas vidas, entre ellas la suya.La crítica ha dicho:«Jambrina bebe de los influjos [de Umberto Eco] para relatar tramas en las que los protagonistas son fieles a la historia de España».El Diario de MallorcaSobre El manuscrito de piedra«Un escenario y una época que sostienen una trama negra al mejor estilo Arthur Conan Doyle».Paula Corroto, Público«GarcíaJambrina convierte en éxito un thriller con Fernando de Rojas como personaje».Miguel Ángel Villena, El País«Combina a la perfección la estructura clásica de novela detectivesca con un conocimiento que se percibe real, profundo y reposado del ambiente salmantino del primer Renacimiento y de la literatura de la época».Sergio Vila-Sanjuán, La Vanguardia«Me ha divertido mucho [...] con su calma erudición y su espíritu aventurero».Alberto ManguelSobre El manuscrito de nieve«Una novela que respira y transpira inteligencia. […] La mejor novela del año».Tino Pertierra, La Nueva España«Un estilo ágil, claro y preciso y grandes dosis de inteligencia, imaginación e ironía».Lecturalia«Creación literaria en profundidad».Rosa Navarro Durán, Ínsula
Static properties and Semileptonic transitions of lowest-lying double heavy baryons
Creators: name: Ghalenovi, Zahra
name: Sorkhi, Masoumeh Moazzen
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The static properties and semileptonic decays of ground-state doubly heavy baryons are studied working in the framework of a non-relativistic quark model. Using a phenomenological potential model, we calculate the ground-state masses and magnetic moments of doubly heavy $ Ω$ and $ Ξ$ baryons. In the heavy quark limit, we introduce a simple form of the universal Isgur-Wise function used as the transition form factor and then investigate the exclusive $ b \rightarrow c $ semileptonic decay widths and branching ratios for $ \frac{1}{2}\rightarrow \frac{1}{2} $ baryon transitions. Our obtained results are in agreement with other theoretical predictions.
description: Accepted for publication in Chin. Phys. c
TODO LO QUE SE SOBRE EL AMOR EBOOK | DOLLY ALDERTON | Descargar libro PDF EPUB
Creators: name: Christopher
Publisher: name: Zenodo
Year: 2024

description: TODO LO QUE SE SOBRE EL AMOR de DOLLY ALDERTON

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TODO LO QUE SE SOBRE EL AMOR

DOLLY ALDERTON

Número de páginas: 384

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408214359

Editorial: PLANETA

Año de edición: 2019

 

 

 

 

 

Bestseller ebooks descargar gratis TODO LO QUE SE SOBRE EL AMOR (Spanish Edition) 9788408214359 de DOLLY ALDERTON

 

Overview

N.º1 en Reino Unido. Medio millón de ejemplares vendidos.La Bridget Jones de la era millennial.

Tan salvajemente divertido y conmovedor como la vida de cualquier veinteañero que crece navegando entre desengaños amorosos y relaciones desastrosasLa periodista Dolly Alderton se propuso dar cuenta de sus locos veinte años en este divertido libro trufado de amores y desamores, relaciones intensas por Messenger que fracasan en el cara a cara, trabajos precarios y amigos que siempre están ahí. Un novio que acaba saliendo del armario, borracheras que te llevan a cruzar el país en taxis que no puedes pagar, chicos sin redes sociales que se creen Sartre…, escenas todas ellas de nuestra lucha por entender que el amor más intenso e importante es el que sentimos por nuestros amigos y nosotros mismos.«Casi todo lo que sé sobre el amor lo he aprendido charlando con mis amigas de toda la vida. He aprendido que el amor es júbilo desenfrenado, bailar borracha sobre el fango de un festival de música, los cruces de miradas en un autobús nocturno, los polvos de una noche. Pero también he aprendido que el amor no son las relaciones tediosas, ni las horas de obsesivo seguimiento en Instagram al chico que te gusta, ni los orgasmos fingidos.»«No quería que acabara nunca», Marian KeyesN.º1 ...
[PDF/Kindle] The Atlas Paradox by Olivie Blake
Creators: name: Allison
Publisher: name: Zenodo
Year: 2024

description: The Atlas Paradox by Olivie Blake

 

 

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The Atlas Paradox

Olivie Blake

Page: 416

Format: pdf, ePub, mobi, fb2

ISBN: 9781250882226

Publisher: Tom Doherty Associates

 

Free ebook download epub The Atlas Paradox

The Atlas Paradox Audiobook by Olivie Blake - Rakuten Kobo Listen to "The Atlas Paradox" by Olivie Blake available from Rakuten Kobo. Narrated by Alexandra Palting. Start a free 30-day trial today and get your first  THE ATLAS PARADOX: Sequel Preview - Olivie Blake THE PARADOX: If power is a thing to be had, then it must be capable of possession. But power does not contain any discrete size or weight, and  The Atlas Paradox by Olivie Blake - OverDrive The Atlas Paradox is the long-awaited sequel to Olivie Blake's New York Times bestselling dark academic sensation The Atlas Six—guaranteed to have even more  The Atlas Paradox a book by Olivie Blake - Bookshop The Atlas Paradox is the long-awaited sequel to Olivie Blake's New York Times bestselling dark academic sensation The Atlas Six--guaranteed to have even  The Atlas Paradox | Bookreporter.com THE ATLAS PARADOX is the long-awaited sequel to Olivie Blake's New York Times bestselling dark academic sensation THE ATLAS SIX --- guaranteed to have even
Cryptosporidium parvum activates nuclear factor κB in biliary epithelia preventing epithelial cell apoptosis
Creators: name: Levine, Susan A.
name: Ganong, Amanda L.
name: Tietz, Pamela S.
name: Splinter, Patrick L.
name: Paya, Carlos V.
name: Chen, Xian Ming
name: LaRusso, Nicholas F.
name: Gores, Gregory J.
name: Jobin, Christian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: AbstractBackground & Aims: Our previous studies have shown that Cryptosporidium parvum induces biliary epithelial cell apoptosis in vivo and causes apoptosis in bystander uninfected biliary epithelia in vitro. We analyzed C. parvum–induced nuclear factor kappa B (NF-κB) activation in human biliary epithelial cells and assessed its relevance to epithelial cell apoptosis. Methods: In vitro models of cryptosporidial infection using a human biliary epithelial cell line were used to assay C. parvum– induced NF-κB activation and associated apoptosis. Results: Degradation of IκB and nuclear translocation of the NF-κB family of proteins (p65 and p50) were observed in the biliary epithelial cell cultures directly exposed to the parasite. Activation of NF-κB was found only in directly infected cells (but not in bystander uninfected cells). A time-dependent secretion of a known NF-κB gene product, interleukin 8, from infected cell cultures was detected. C. parvum–induced biliary epithelial cell apoptosis was limited to bystander uninfected cells. In contrast, inhibition of NF-κB activation resulted in apoptosis in directly infected cells and significantly enhanced C. parvum–induced apoptosis in bystander uninfected cells. Conclusions: These observations support the concept that, while C. parvum triggers host cell apoptosis in bystander uninfected biliary epithelial cells, which may limit spread of the infection, it directly activates the NF-κB/IκB system in infected biliary epithelia thus protecting infected cells from death and facilitating parasite survival and propagation.GASTROENTEROLOGY 2001;120:1774-1783
Harnessing the polymer-particle duality of ultra-soft nanogels to stabilise smart emulsions
Creators: name: Petrunin, Alexander V.
name: Bochenek, Steffen
name: Richtering, Walter
name: Scotti, Andrea
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Micro- and nanogels are widely used to stabilise emulsions and simultaneously implement their responsiveness to the external stimuli. One of the factors that improves the emulsion stability is the nanogel softness. Here, we study how the softest nanogels that can be synthesised with precipitation polymerisation of N-isopropylacrylamide (NIPAM), the ultra-low crosslinked (ULC) nanogels, stabilise oil-in-water emulsions. We show that ULC nanogels can efficiently stabilise emulsions already at low mass concentrations. These emulsions are resistant to droplet flocculation, stable against coalescence, and can be easily broken upon an increase in temperature. The resistance to flocculation of the ULC-stabilised emulsion droplets is similar to the one of emulsions stabilised by linear pNIPAM. In contrast, the stability against coalescence and the temperature-responsiveness closely resemble the one of emulsions stabilised by regularly crosslinked pNIPAM nanogels. The reason for this combination of properties is that ULC nanogels can be thought of as colloids in between flexible macromolecules and particles. As a polymer, ULC nanogels can efficiently stretch at the interface and cover it uniformly. As a regularly crosslinked nanogel particle, ULC nanogels protect emulsion droplets against coalescence by providing a steric barrier and rapidly respond to changes in external stimuli thus breaking the emulsion. This polymer-particle duality of ULC nanogels can be exploited to improve the properties of emulsions for various applications, for example in heterogeneous catalysis or in food science.
Supplementary Figure S1 from How the embryonic chick brain twists
Creators: name: Chen, Zi
name: Qiaohang Guo
name: Dai, Eric
name: Forsch, Nickolas
name: Taber, Larry A.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Biophysics
subject: Biological Engineering
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Measurement of the torsional angle from the OCT images
Cystic fibrosis gene mutations and pancreatitis risk: Relation to epithelial ion transport and trypsin inhibitor gene mutations
Creators: name: Zhou, Zhaoqing
name: Knowles, Michael R.
name: Cohn, Jonathan A.
name: Silverman, Lawrence M.
name: Jowell, Paul S.
name: Noone, Peadar G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Abstract Background & Aims: Nonalcoholic chronic pancreatitis is usually idiopathic and often associated with cystic fibrosis gene (CFTR) mutations. It is unknown whether pancreatitis risk correlates with having 1 or 2 CFTR mutations, abnormal epithelial ion transport, or mutations of other genes. Methods: We tested 39 patients with idiopathic chronic pancreatitis (mean age at diagnosis, 33 years) for common mutations of CFTR and of genes encoding a trypsin inhibitor (PSTI) and trypsinogen (PRSS1). To exclude hereditary pancreatitis, we initially relied on family history and subsequently tested for PRSS1 mutations. Twenty subjects were tested for rare CFTR mutations (DNA sequencing) and 11 were tested for extrapancreatic CFTR function (clinical and physiologic evaluation). Results: Mutations were identified in 24 of 39 subjects. Nine patients had cystic fibrosis–causing mutations, 8 of whom also had mild-variable mutations. Eight others had only mild-variable mutations. Nine subjects had the N34S PSTI mutation and 1 had hereditary pancreatitis (R122H, PRSS1). Pancreatitis risk was increased approximately 40-fold by having 2 CFTR mutations (P < 0.0001), 20-fold by having N34S (P < 0.0001), and 900-fold by having both (P < 0.0001). Subjects with 2 CFTR mutations had abnormal nasal epithelial ion transport and clinical findings suggesting residual CFTR function between that in cystic fibrosis and in carriers. By contrast, subjects with only PSTI mutations had normal CFTR function. Conclusions: CFTR-related pancreatitis risk correlates with having 2 CFTR mutations and reduced extrapancreatic CFTR function. The N34S PSTI mutation increased risk separately. Testing for pancreatitis-associated CFTR and PSTI genotypes may be useful in nonalcoholic pancreatitis.GASTROENTEROLOGY 2001;121:1310-1319
Three-Sensor 3ω-2ω Method for the Simultaneous Measurement of Thermal Conductivity and Thermal Boundary Resistance in Film-on-Substrate Heterostructures
Creators: name: Yang, Guang
name: Cao, Bing-Yang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Solid heterostructures composed of substrates and epitaxial films are extensively used in advanced technologies, and their thermophysical properties fundamentally determine the performance, efficiency, reliability, and lifetime of the corresponding devices. However, an experimental method that is truly appropriate for the thermophysical property measurement of solid heterostructures is still lacking. To this end, a three-sensor 3ω-2ω method is proposed, which can simultaneously measure the thermal conductivities of the film and the substrate, along with the film-substrate thermal boundary resistance (TBR) in a single solid heterostructure without any reference samples, showing broad applicability for miscellaneous heterostructures with film thickness ranging from 100 nm to 10 μm. In this method, three parallel metal sensors with unequal width and spacing are fabricated on the sample surface, in which the two outer sensors are used as heaters, and the middle sensor is used as a detector. The respective 3ω signals of the two heaters and 2ω signal of the detector are measured, and then the thermophysical properties of the sample are fitted within 3D finite element simulations. To verify this method, two typical wide bandgap semiconductor heterojunctions, i.e., GaN on SiC (#SiC) and GaN on Si (#Si) with ~2.3 μm GaN epilayers, are measured. The thermal conductivity of the GaN film, the thermal conductivities of the SiC and Si substrates, and the GaN/substrate TBRs are derived, exhibiting good agreement with the reported values in the literature. The proposed method will provide a comprehensive solution for the thermophysical property measurements of various solid heterostructures.
Spectroscopy of higher bottomonia
Creators: name: Ferretti, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this contribution, we discuss our recent unquenched quark model results for the spectrum of $b \bar b$ mesons with self energy corrections, due to the coupling to the meson-meson continuum. Our unquenched quark model predictions for the masses of the recently discovered $χ_b(3P)$ states are compared to those of a re-fit of Godfrey and Isgur's relativized quark model to the most recent experimental data. The possible importance of continuum effects in the $χ_b(3P)$ states is discussed. Finally, we show our quark model results for the radiative decays of the $χ_b(3P)$ system and the open-bottom decays of $b \bar b$ mesons.
description: Talk given at the conference "Dark Matter, Hadron Physics and Fusion Physics", Messina (Italy), September 24-26, 2014
(3034) Florence Tate
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Enhanced survival and mucosal repair after dextran sodium sulfate–induced colitis in transgenic mice that overexpress growth hormone
Creators: name: Haldeman, Kaaren M.
name: DaCosta, Chris M.
name: Fuller, C. Randall
name: Lund, P. Kay
name: Sartor, R. Balfour
name: Dieleman, Levinus A.
name: Williams, Kristen L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: AbstractBackground & Aims: Growth hormone (GH) is used as therapy for inflammatory bowel disease (IBD), but the specific effects on intestine are unknown. Transgenic mice overexpressing GH (MT1-bGH-TG) were used to test whether increased plasma GH levels alter inflammation or crypt damage during dextran sodium sulfate (DSS)-induced colitis. Methods: MT1-bGH-TG and wild-type (WT) littermates were given 3% DSS for 5 days followed by up to 10 days of recovery. Colitis and epithelial cell proliferation were evaluated histologically. Plasma insulin-like growth factor (IGF)-I and colonic IGF-I, interleukin (IL)-1β, and intestinal trefoil factor (ITF) messenger RNAs (mRNAs) were measured. Results: DSS induced similar disease onset in MT1-bGH-TG and WT. More MT1-bGH-TG survived than WT. By recovery day 7, MT1-bGH-TG had less inflammation and crypt damage, elevated plasma IGF-I, and increased colonic ITF expression relative to WT. Colonic IL-1β was elevated in DSS-treated MT1-bGH-TG and WT, but IL-1β mRNA abundance correlated with disease only in WT. MT1-bGH-TG showed earlier increases in epithelial cell proliferation than WT during recovery but only WT showed atypical repair. Conclusions: GH does not alter susceptibility to acute DSS-induced colitis but enhances survival, remission of inflammation, and mucosal repair during recovery. GH therapy may be beneficial during active IBD by improving mucosal repair.GASTROENTEROLOGY 2001;120:925-937
HLA similarity calculation from Men's preferences for women's body odours are not associated with human leucocyte antigen.
Creators: name: Probst, Fabian
name: Fischbacher, Urs
name: Lobmaier, Janek S.
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Additional information regarding the pre-selection of similar and dissimilar odour pads
title: Defining the importance of mitochondrial genotype in determining individual variation in hepatic fatty acid oxidation and dysregulation
Creators: name: Jensen, Rebecca
Publisher: name: University of Liverpool Repository
Year: 2024

description: Fatty acid oxidation (FAO) is one of the main pathways for energy production in the mitochondria, with dysregulation of this pathway potentially being a cause of metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD), and can also be a mechanism of drug-induced steatohepatitis (DIS). Due to mitochondria containing their own genome (mtDNA) and having a role in the pathogenesis of NAFLD and DIS, research is needed to understand the role of mitochondrial haplogroup on energy metabolism pathways and the link to NAFLD and DIS. 
Therefore, the overall aim of the research within this thesis was to understand the effect of the mitochondrial haplogroup on basal energy metabolism pathways and the development of steatosis and subsequent toxicity. A personalised 3D in vitro HepG2 transmitochondrial cybrid and stellate cell co-culture liver model was developed to assess the role of the mitochondrial genome in the onset and progression of NAFLD and susceptibility to toxicants. Oleic and palmitic acid (OAPA) were used as a physiological inducer of steatosis and amiodarone was utilised as a chemical inducer of steatosis to assess the role of the mitochondrial genome in lipid accumulation and subsequent toxicity. AZD1979 was used to unravel inter-individual and interspecies mitochondrial susceptibility factors in drug-induced liver injury (DILI). 
Initial investigations using the AdipoRed assay showed that there were no haplogroup-specific differences between transmitochondrial cybrids in the amount of lipid accumulation, after OAPA and amiodarone treatments. However, further studies into the mitochondrial respiratory function and bioenergetic parameters revealed haplogroup-specific differences after treatment with OAPA, amiodarone and AZD1979. Macrohaplogroup J consistently showed impaired mitochondrial function after all the treatments, suggesting this haplogroup is more susceptible to mitochondrial damage compared to the other haplogroups. Furthermore, haplogroup J2b1g showed an increase in COL1A1 expression after OAPA treatment even though there was no change in the mtDNA being released from the cell into the supernatant which may have triggered collagen activation.
To conclude, these studies suggest a role for mtDNA as a susceptibility or protective factor in the onset and progression of NAFLD and DIS and establishes a new personalised model which could be used in industry for research into therapies for NAFLD treatment and as part of pre-clinical safety testing of new drugs. It also highlights the difficulties which come with using 3D model systems and shows that it could also be beneficial to use more simplified 2D in vitro models to identify key targets in the disease pathogenesis before moving into more complex systems.
(3036) James A Tate
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Growth Retardation, Duodenal Lesions, and Aberrant Ileum Architecture in Triple Null Mice Lacking EGF, Amphiregulin, and TGF-α
Creators: name: Luetteke, Noreen C.
name: Qiu, Ting Hu
name: Saxon, Marian L.
name: Troyer, Kelly L.
name: Lee, David C.
name: Xian, Cory J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: BACKGROUND AND AIMS: Mice lacking epidermal growth factor (EGF), transforming growth factor alpha, and amphiregulin were used to identify roles for these EGF receptor (EGF-R) ligands in gastrointestinal development and mucosal integrity.

METHODS: Gastrointestinal tract development was examined in knockout mice and correlated with expression of EGF-R protein and EGF family members throughout the gut. Crossfostering experiments addressed roles of maternal- and neonatal-derived ligands in pup growth and intestinal development. Cysteamine-induced ulceration in EGF(-/-) mice was used to examine its role in mucosal cytoprotection.

RESULTS: Neonatal mice lacking all 3 ligands were growth retarded, even when reared by wild-type dams; conversely, lack of maternal ligands transiently impaired wild-type pup growth. Triple null neonates displayed spontaneous duodenal lesions, and ileal villi were truncated and fragile with reduced cellular proliferation in the crypts. However, maturation of digestive enzymes was unaffected. Adult EGF(-/-) mice displayed more severe lesions in response to cysteamine treatment compared with wild-type counterparts, although triple null mice were not more susceptible to dextran sulfate sodium-induced colitis, suggesting a differential role for these ligands in the injury response.

CONCLUSIONS: EGF-R ligands are required for development and mucosal maintenance in mouse small intestine. Both maternal and neonatal sources of growth factors are required for optimal pup growth.
{pdf download} Heal Your Living: The Joy of Mindfulness, Sustainability, Minimalism, and Wellness by Youheum Son
Creators: name: Peterson
Publisher: name: Zenodo
Year: 2024

description: Heal Your Living: The Joy of Mindfulness, Sustainability, Minimalism, and Wellness by Youheum Son

 

 

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Heal Your Living: The Joy of Mindfulness, Sustainability, Minimalism, and Wellness

Youheum Son

Page: 160

Format: pdf, ePub, mobi, fb2

ISBN: 9781952692154

Publisher: Parallax Press

 

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NF-κB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-α– and Fas-mediated apoptosis
Creators: name: Bennett, Brydon L.
name: Brenner, David A.
name: Hatano, Etsuro
name: Qian, Ting
name: Manning, Anthony M.
name: Lemasters, John J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: AbstractBackground & Aims: Hepatocyte apoptosis is induced by tumor necrosis factor α (TNF-α) and Fas ligand. Although nuclear factor–κB (NF-κB) activation protects hepatocytes from TNF-α–mediated apoptosis, the NF-κB responsive genes that protect hepatocytes are unknown. Our aim was to study the role of NF-κB activation and inducible nitric oxide synthases (iNOSs) in TNF-α– and Fas-mediated apoptosis in hepatocytes. Methods: Primary cultures of hepatocytes from wild-type and iNOS knockout mice were treated with TNF-α, the Fas agonistic antibody Jo2, a nitric oxide (NO) donor (S-nitroso-N-acetylpenicillamine), an NO inhibitor (NG-methyl-L-arginine acetate), and/or adenovirus-expressing NF-κB inhibitors. Results: The IκB superrepressor and a dominant-negative form of IκB kinase beta (IKKβ) inhibited NF-κB binding activity by TNF-α or Jo2 and sensitized hepatocytes to TNF-α– and Jo2-mediated apoptosis. TNF-α and Jo2 induced iNOS messenger RNA and protein levels through the induction of NF-κB. S-nitroso-N-acetylpenicillamine inhibited Bid cleavage, the mitochondrial permeability transition, cytochrome c release, and caspase-8 and -3 activity, and reduced TNF-α– and Fas-mediated death in hepatocytes expressing IκB superrepressor. NG-methyl-L-arginine acetate partially sensitized hepatocytes to TNF-α– and Fas-mediated cell killing. TNF-α alone or Jo2 alone induced moderate cell death in hepatocytes from iNOS−/− mice. Conclusions: NO protects hepatocytes from TNF-α– and Fas-mediated apoptosis. Endogenous iNOS, which is activated by NF-κB via IKKβ, provides partial protection from apoptosis.GASTROENTEROLOGY 2001;120:1251-1262