cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Conformal Scaling Gauge Symmetry and Inflationary Universe
Creators: name: Wu, Yue-Liang
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Considering the conformal scaling gauge symmetry as a fundamental symmetry of nature in the presence of gravity, a scalar field is required and used to describe the scale behavior of universe. In order for the scalar field to be a physical field, a gauge field is necessary to be introduced. A gauge invariant potential action is constructed by adopting the scalar field and a real Wilson-like line element of the gauge field. Of particular, the conformal scaling gauge symmetry can be broken down explicitly via fixing gauge to match the Einstein-Hilbert action of gravity. As a nontrivial background field solution of pure gauge has a minimal energy in gauge interactions, the evolution of universe is then dominated at earlier time by the potential energy of background field characterized by a scalar field. Since the background field of pure gauge leads to an exponential potential model of a scalar field, the universe is driven by a power-law inflation with the scale factor $a(t) \sim t^p$. The power-law index $p$ is determined by a basic gauge fixing parameter $g_F$ via $p = 16πg_F^2[1 + 3/(4πg_F^2) ]$. For the gauge fixing scale being the Planck mass, we are led to a predictive model with $g_F=1$ and $p\simeq 62$.
description: 12 pages, RevTex, no figures
The double-edged sword of acculturation: Navigating work-family conflict among immigrants
Creators: name: Shang, Sudong
name: Yao, Christian
name: Roche, Maree
name: Wang, Minghui
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2025
Subjects: classificationCode: 3507
subject: Strategy, management and organisational behaviour
classificationCode: 4702
subject: Cultural studies
classificationCode: 4404
subject: Development studies

description: No description supplied
Additional file 15 of Japanese quail (Coturnix japonica) as a novel model to study the relationship between the avian microbiome and microbial endocrinology-based host-microbe interactions
Creators: name: Lyte, Joshua M.
name: Keane, James
name: Eckenberger, Julia
name: Anthony, Nicholas
name: Sandip Shrestha
name: Marasini, Daya
name: Daniels, Karrie M.
name: Caputi, Valentina
name: Donoghue, Annie M.
name: Lyte, Mark
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Computational Biology

description: Additional file 14: Supplemental Table 5. Title of data (Correlation metrics for significant associations from the low stress ensemble network). Description of data. (Statistical scores from the Conet Analysis (Pearson, Spearman, Bray Curtis, Kullback-Liebler and Mutual Information) that support inclusion of an edge in the low stress ensemble network. qvalues (Adjusted pvalues) for each edge in the low stress ensemble network from the Conet, Spearman and Pearson networks are also presented).
Tairiku Nippo
大陸日報
Creators: name: (:Null)
Publisher: name: Vancouver, BC : Tairiku Nippŏsha
Year: 2016

description: 本日の貴族院で日露戦争の噂が問題；　ロシアとの関係は好結果なく迷惑；　衆議院本会議；　ガーデナー研究会；　福岡海協の新幹部決定；　シーダコーブ愛友会新幹部；　カルタ大会に；　妄弁苦言
Deep Clustering of Compressed Variational Embeddings
Creators: name: Wu, Suya
name: Diao, Enmao
name: Ding, Jie
name: Tarokh, Vahid
Publisher: name: arXiv
Year: 2019
Subjects: subject: Image and Video Processing (eess.IV)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Motivated by the ever-increasing demands for limited communication bandwidth and low-power consumption, we propose a new methodology, named joint Variational Autoencoders with Bernoulli mixture models (VAB), for performing clustering in the compressed data domain. The idea is to reduce the data dimension by Variational Autoencoders (VAEs) and group data representations by Bernoulli mixture models (BMMs). Once jointly trained for compression and clustering, the model can be decomposed into two parts: a data vendor that encodes the raw data into compressed data, and a data consumer that classifies the received (compressed) data. In this way, the data vendor benefits from data security and communication bandwidth, while the data consumer benefits from low computational complexity. To enable training using the gradient descent algorithm, we propose to use the Gumbel-Softmax distribution to resolve the infeasibility of the back-propagation algorithm when assessing categorical samples.
description: Submitted to the IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), Barcelona, Spain, May 2020
Wakeful Prone “Tummy Time” During Infancy: How Can We Help Parents?
Creators: name: Felzer-Kim, Isabella Theresa
name: Erickson, Karl
name: Adkins, Chelsea
name: Hauck, Janet L.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Aims: This study’s purpose is to present facilitators and barriers for wakeful prone positioning or “tummy time” during infancy by exploring the personal perspectives of infant caregivers attempting to provide daily tummy time. Methods: The study was qualitative in design, using thematic analysis to identify major and minor themes from semi-structured interviews. The Capability, Opportunity, Motivation – Behavior Model provided a conceptual framework for the interview guide and categorization of major themes. Results: Within capability, opportunity, and motivation, the major themes of self-efficacy, scheduling, variations, siblings, committed adult help, social responses of acquaintances, and caregiver enjoyment could be barriers or facilitators, depending on the context. Optimized physical circumstances, caregiver interest, perceived benefits to the infant, pride and accomplishment, and obligation were identified as facilitators only. Barriers included negative infant affect. Conclusions: These results offer preliminary guidance in a knowledge gap: tummy time support that addresses the self-identified concerns of infant caregivers.
Additional file 16 of Japanese quail (Coturnix japonica) as a novel model to study the relationship between the avian microbiome and microbial endocrinology-based host-microbe interactions
Creators: name: Lyte, Joshua M.
name: Keane, James
name: Eckenberger, Julia
name: Anthony, Nicholas
name: Sandip Shrestha
name: Marasini, Daya
name: Daniels, Karrie M.
name: Caputi, Valentina
name: Donoghue, Annie M.
name: Lyte, Mark
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Computational Biology

description: Additional file 15: Supplemental Table 6. Title of data (Correlation metrics for significant associations from the high stress ensemble network). Description of data. (Statistical scores from the Conet Analysis (Pearson, Spearman, Bray Curtis, Kullback-Liebler and Mutual Information) that support inclusion of an edge in the high stress ensemble network. qvalues (Adjusted pvalues) for each edge in the high stress ensemble network from the Conet, Spearman and Pearson networks are also presented).
OPERAÇÕES DE “CASH-AND-CARRY ARBITRAGE” NA BM&F: UMA DESAGREGAÇÃO DOS CUSTOS
Creators: name: Silva, Gustavo De Souza E
name: Marques, Pedro Valentim
name: Silva, Gustavo De Souza E
name: Marques, Pedro Valentim
Publisher: name: Unknown
Year: 2006
Subjects: Demand and Price Analysis

description: A explosão dos mercados futuros se deve a eventos da economia mundial que resultaram num maior e mais volátil cenário de preços e taxas de juros, surgindo possibilidades para obtenção de lucros através de diversas operações. Uma dessas operações é conhecida como “Cash and Carry Arbitrage”. Conhecer os custos desta operação e a respectiva participação no custo total é fundamental para que os agentes possam aumentar a possibilidade de captar o maior retorno de cada operação, travando-a no momento mais apropriado. O custo da operação de “Cash and Carry Arbitrage” pode ser desagregado em quatro custos gerais: 1) custo do dinheiro no tempo; 2) custo da armazenagem; 3) custo para operar na BM&F; e 4) custos dos impostos incidentes. Os custos de armazenagem e o do dinheiro no tempo registraram as maiores participações no custo total das operações, sendo estes altamente relacionados com o tempo da operação.
ALTERNATIVAS DE INVESTIMENTOS PARA O CERTIFICADO DE DEPÓSITO AGROPECUÁRIO / WARRANT AGROPECUÁRIO (CDA/WA)
Creators: name: Silva, Gustavo De Souza E
name: Marques, Pedro Valentim
name: Silva, Gustavo De Souza E
name: Marques, Pedro Valentim
Publisher: name: Unknown
Year: 2006
Subjects: Agribusiness
Agricultural and Food Policy

description: A Lei no 11.076, de 30 de dezembro de 2004, oficializou cinco títulos de créditos que deverão ser utilizados pelo agronegócio para captar recursos privados para o seu financiamento : Certificado de Depósito Agropecuário (CDA), Warrant Agropecuário (WA), Certificados de Direitos Creditórios do Agronegócio (CDCA), Letra de Crédito do Agronegócio (LCA) e Certificado de Recebíveis do Agronegócio (CRA). Este trabalho apresenta esses novos instrumentos de financiamento e busca alternativas de investimento para o CDA/WA nos mercados físicos e futuros de janeiro a outubro de 2005. Duas situações foram consideradas: 1) especulações com o CDA/WA, onde o investidor adquire o papel e especula com cada produto, sendo seu resultado comparado a quatro investimentos tradicionais do mercado financeiro brasileiro: 1) rendimento da poupança; 2) taxa de juros Selic; 3) dólar americano; e 4) índice Bovespa.; e 2) operação de spread, onde o investidor compra o CDA/WA e trava o rendimento numa operação com o mercado futuro, sem ficar exposto a variações de preço. A partir disso, concluiu-se que a especulação com os produtos agrícolas não teve um bom resultado no período. Já as operações de spread ofereceram boas oportunidades de rentabilidade ao investidor que conseguiu captar o momento correto para a operação.
A spectroscopic search for faint secondaries in cataclysmic variables
Creators: name: Putte, D. Vande
name: Smith, Robert Connon
name: Hawkins, N. A.
name: Martin, J. S.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The secondary in cataclysmic variables (CV's) is usually detected by cross-correlation of the CV spectrum with that of a K or M dwarf template, to produce a radial velocity curve. Although this method has demonstrated its power, it has its limits in the case of noisy spectra, such as are found when the secondary is faint. A method of co-adding spectra, called skew mapping, has been proposed in the past. Gradually, examples of its application are being published. Nonetheless, so far no journal article has described the technique in detail. To answer this need, this paper explores in detail the capabilities of skew mapping when determining the amplitude of the radial velocity for faint secondaries. It demonstrates the method's power over techniques that are more conventional, when the signal-to-noise (s/n) ratio is poor. The paper suggests an approach to assessing the quality of results. This leads in the case of the investigated objects to a first tier of results, where we find K2=127+-23 km/s for SY Cnc, K2=144+-18 km/s for RW Sex, and K2=262+-14 km/s for UX UMa. These we believe to be the first direct determinations of K2 for these objects. Furthermore, we also obtain K2=263+-30 km/s for RW Tri, close to a skew mapping result obtained elsewhere. In the first three cases, we use these results to derive the mass of the white dwarf companion. A second tier of results includes UU Aqr, EX Hya, and LX Ser, for which we propose more tentative values of K2. Clear failures of the method are also discussed (EF Eri, VV Pup, SW Sex).
description: 23 pages, 22 figures, 10 tables; translated to pdf from a Word file - no TeX version available. Accepted for publication in MNRAS
MOESM2 of Optimisation: defining and exploring a concept to enhance the impact of public health initiatives
Creators: name: Wolfenden, Luke
name: Bolsewicz, Katarzyna
name: Grady, Alice
name: McCrabb, Sam
name: Kingsland, Melanie
name: Wiggers, John
name: Bauman, Adrian
name: Wyse, Rebecca
name: Nathan, Nicole
name: Sutherland, Rachel
name: Hodder, Rebecca
name: Fernandez, Maria
name: Lewis, Cara
name: Taylor, Natalie
name: McKay, Heather
name: Grimshaw, Jeremy
name: Hall, Alix
name: Moullin, Joanna
name: Albers, Bianca
name: Batchelor, Samantha
name: Attia, John
name: Milat, Andrew
name: Bailey, Andrew
name: Rissel, Chris
name: Reeves, Penny
name: Sims-Gould, Joanie
name: Mildon, Robyn
name: Doran, Chris
name: Sze Yoong
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file 2.Â Conceptual map of 'Optimisation' derived from the literature.
Elucidating specific interactions for designing novel pyrrolamide derivatives as potential GyrB inhibitors based on ab initio fragment molecular orbital calculations
Creators: name: Thongdee, Paptawan
name: Nagura, Yoshinobu
name: Sabishiro, Haruna
name: Phusi, Naruedon
name: Sukchit, Darunee
name: Kamsri, Pharit
name: Punkvang, Auradee
name: Suttisintong, Khomson
name: Pungpo, Pornpan
name: Kurita, Noriyuki
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Tuberculosis (TB), the second leading infectious killer, causes serious public health problems worldwide. To develop novel anti-TB agents, many biochemical studies have targeted the subunit B of DNA gyrase (GyrB), which captures a second DNA segment and responses for ATP hydrolysis. Here, we investigated specific interactions between GyrB residues and existing pyrrolamide derivatives at an electronic level using ab initio fragment molecular orbital (FMO) calculations and designed potent inhibitors against GyrB. The evaluated binding affinities between GyrB and pyrrolamides were confirmed to be consistent with the IC50 values obtained from previous experiments. Thus, we employed the most potent pyrrolamide (compound 1) as a lead compound and proposed novel pyrrolamide derivatives. The specific interactions between GyrB and these derivatives were investigated using molecular mechanic optimizations and FMO calculations. The results revealed that our proposed derivatives had strong hydrogen bonds with Asp79 and Arg141 and exhibited electrostatic interactions with Glu56 and Ile84 of GyrB. In addition, the binding affinity between GyrB and compound 1 was enhanced significantly by the replacement at the R3 site of compound 1. The present results may provide structural concepts for the rational design of potent GyrB inhibitors as anti-TB agents.
Non-collinear antiferromagnetic states in Ru-based Heusler compounds induced by biquadratic coupling
Creators: name: Simon, Eszter
name: Donges, Andreas
name: Szunyogh, László
name: Nowak, Ulrich
Publisher: name: arXiv
Year: 2019
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the magnetic properties of Ru$_{2}$Mn$Z$ ($Z$ = Sn, Sb, Ge, Si) chemically ordered full Heusler compounds for zero as well as finite temperatures. Based on first principles calculations we derive the interatomic isotropic bilinear and biquadratic couplings between Mn atoms from the paramagnetic state. We find frustrated isotropic couplings for all compounds and in case of $Z$ = Si and Sb a nearest-neighbor biquadratic coupling that favors perpendicular alignment between the Mn spins. By using an extended classical Heisenberg model in combination with spin dynamics simulations we obtain the magnetic equilibrium states. From these simulations we conclude that the biquadratic coupling, in combination with the frustrated isotropic interactions, leads to non-collinear magnetic ground states in the Ru$_{2}$MnSi and Ru$_{2}$MnSb compounds. In particular, for these alloys we find two distinct, non-collinear ground states which are energetically equivalent and can be identified as $3-q$ and $4-q$ states on a frustrated fcc lattice. Investigating the thermal stability of the non-collinear phase we find that in case of Ru$_{2}$MnSi the multiple$-q$ phase undergoes a transition to the single$-q$ phase, while in case of Ru$_{2}$MnSb the corresponding transition is not obtained due to the larger magnitude of the nearest-neighbor biquadratic coupling.
description: 7 pages, 6 figures, 1 table
Additional file 17 of Japanese quail (Coturnix japonica) as a novel model to study the relationship between the avian microbiome and microbial endocrinology-based host-microbe interactions
Creators: name: Lyte, Joshua M.
name: Keane, James
name: Eckenberger, Julia
name: Anthony, Nicholas
name: Sandip Shrestha
name: Marasini, Daya
name: Daniels, Karrie M.
name: Caputi, Valentina
name: Donoghue, Annie M.
name: Lyte, Mark
Publisher: name: figshare
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Computational Biology

description: Additional file 16: Supplemental Table 7. Title of data (ANOVA Tables from permutation tests on CCA models). Description of data. (ANOVA Tables from permutation tests CCA models of microbiota composition regressed on chemical concentrations in cecal, colon, jejunum, liver, lung and plasma samples. For each variable within the ANOVA table the following information is presented: the model degrees of freedom, the Chi Square coefficient, the F score and pvalue).
ANÁLISE DA QUALIDADE DE VIDA E DO DESENVOLVIMENTO HUMANO DAS FAMÍLIAS DAS BORDADEIRAS DE ITAPAJÉ – CE (*)
Creators: name: Filgueiras, Araguacy Paixao Almeida
name: Carvalho, Rosemeiry Melo
name: Casimiro Filho, Francisco
name: Filgueiras, Araguacy Paixao Almeida
name: Carvalho, Rosemeiry Melo
name: Casimiro Filho, Francisco
Publisher: name: Unknown
Year: 2006
Subjects: subject: Community/Rural/Urban Development
subject: Artesanato
subject: Moda
subject: Aspectos Socioeconômicos
subject: Desenvolvimento Humano
subject: Qualidade de Vida

description: A produção do artesanato pode ser questionada em virtude do crescimento acelerado da industrialização. Para alguns autores as características do mesmo vêm sofrendo, ao longo do tempo, alterações na sua apresentação em virtude da concorrência com produtos industrializados. Porém, convém ressaltar que o artesanato pode se tornar competitivo em relação ao similar industrializado por apresentar personalização de suas peças, bem como aspectos artísticos e culturais intrínsecos a sua concepção e produção. Todavia, percebe-se, ainda, algumas disparidades do artesanato diante das inovações tecnológicas e das exigências do mercado consumidor, tendo em vista, as incipientes formas de criação, de produção, de administração e de comercialização. Tendo em vista a relação – artesanato, moda, economia e cultura –, o presente estudo analisa os aspectos socioeconômicos do artesanato em comunidade rural do estado do Ceará, enfocando a qualidade de vida e o desenvolvimento humano das famílias envolvidas. A comunidade de Itapajé foi escolhida como objeto deste estudo por ser um local tradicional em bordados, que vem tentando explorar todas as potencialidades de inserção no mercado de forma a melhorar seu contexto socioeconômico. Assim, pretendeuse analisar a importância do artesanato como elemento propulsor na produção tanto sob os aspectos da preservação da cultura popular, da mão-de-obra utilizada, como também o fator econômico que favorece as unidades produtoras, calculando-se os índices de qualidade de vida -IQV e de desenvolvimento humano –IDH. Tendo em conta o contexto no qual a pesquisa foi realizada, seus resultados podem fornecer parâmetros para os Projetos de Qualificação e Melhoria do Artesanato Cearense, que poderão ser implementados por Instituições como CEART, SEBRAE-CE, SETE – Secretaria de Trabalho e Empreendedorismo do Estado, Prefeitura Municipal e outras políticas públicas.
Tairiku Nippo
大陸日報
Creators: name: (:Null)
Publisher: name: Vancouver, BC : Tairiku Nippŏsha
Year: 2016

description: 足利尊氏問題で痛撃された中島商相；　戦闘機で海軍長距離飛行；　中島は男爵を辞し大臣を辞めよ；　人生五十歳説に異議が出ました；　青棟の下にて
A LOGÍSTICA COMO GARANTIA DE ALIMENTOS MAIS BARATOS: UM ESTUDO DE CASO SOBRE A MOVIMENTAÇÃO DE ARROZ
Creators: name: Payeras, Jose Adrian Pintos
name: Gonzales, Moises Villalba
name: Santos Filho, Jonas Irineu Dos
name: Payeras, Jose Adrian Pintos
name: Gonzales, Moises Villalba
name: Santos Filho, Jonas Irineu Dos
Publisher: name: Unknown
Year: 2006
Subjects: subject: Crop Production/Industries
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: pobreza
subject: fome
subject: custo de transporte
subject: programação linear
subject: arroz

description: O tema da fome ganhou amplo destaque político nos últimos anos, tendo estado presente em diversos debates sobre o desenvolvimento nacional e mundial. No Brasil, estudos foram efetuados sobre o tema visando identificar os seus fatores determinantes. Estes estudos comprovam que o problema da fome no Brasil está relacionado à impossibilidade demanda e não a falta de oferta de alimentos. Desta forma, este artigo buscou investigar, por meio de um modelo de programação linear aplicado na movimentação do arroz, como o estudo logístico pode propiciar melhoria de bem-estar para a população de baixa renda, uma vez que ajuda a observar alternativas que reduzem o custo de transporte. O pressuposto utilizando neste estudo é de que reduções no custo de comercialização são transferidas aos preços pagos pelos consumidores. O estudo de caso envolveu os municípios gaúchos de Itaqui, Cachoeira do Sul, Camaquã, São Sepé, Pelotas e Guaíba como ofertantes de arroz e como demandantes os municípios de Salvador, Maceió, Recife, Fortaleza e Manaus. A escolha dos municípios estudados decorreu da disponibilidade de informações e do fato do estado do Rio Grande do Sul ser o mais importante produtor nacional de arroz. O estudo apontou que, ceteris paribus, a cabotagem é capaz de reduzir, consideravelmente, o custo de transporte do arroz do Sul do país para as cidades selecionadas do Norte e Nordeste. A utilização da cabotagem diminuiu em aproximadamente 40% o custo de transporte. Desta forma, levando-se em consideração o preço praticado nas regiões demandantes, seria possível, com o uso da cabotagem, diminuir o preço do arroz para a população demandante em aproximadamente 10%.
In vitro and in silico exploration of newly synthesized triazolyl- isonicotinohydrazides as potent antitubercular agents
Creators: name: Bakale, Rajubai D.
name: Phatak, Pramod S.
name: Rathod, Sanket S.
name: Choudhari, Prafulla B.
name: Rekha, Estharla Madhu
name: Sriram, Dharmarajan
name: Kulkarni, Ravibhushan S.
name: Haval, Kishan P.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives (4a-r), via the click chemistry approach. The synthesized isoniazid-triazole derivatives have potent in vitro antitubercular activity against the Mycobacterium tuberculosis (MTB) H37Rv strain. Among these compounds, 4b, 4f, 4g, 4j, 4k, 4m, 4o, 4p, and 4r were found to be the most active ones with a MIC value of 0.78 μg/mL. This activity is better than ciprofloxacin (MIC value = 1.56 μg/mL) and ethambutol (MIC value = 3.12 μg/mL). The compounds, 4a, 4c, 4d, 4e, 4h, 4i, 4l, and 4n have displayed activity equal to ciprofloxacin (MIC value = 1.56 μg/mL). The cytotoxicity of the active isoniazid-triazole derivatives was studied against RAW 264.7 cell line by MTT assay at 25 μg/mL concentration and no toxicity was observed. Moreover, in-vitro results were supported by in-silico studies with the known antitubercular target (PanK). The drug-likeness, density functional study, molecular docking, and molecular dynamics simulation studies of isoniazid-triazole derivatives validated the ability to form a stable complex with Pantothenate kinase (PanK), which will result in inhibiting the Pantothenate kinase (PanK). Therefore, the results obtained indicate that this class of compounds may offer candidates for future development, and positively provide drug alternatives for tuberculosis treatment.
Organizing genome engineering for the gigabase scale
Creators: name: Bartley, Bryan A.
name: Beal, Jacob
name: Karr, Jonathan R.
name: Strychalski, Elizabeth A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Genomics (q-bio.GN)
subject: FOS: Biological sciences

description: Engineering the entire genome of an organism enables large-scale changes in organization, function, and external interactions, with significant implications for industry, medicine, and the environment. Improvements to DNA synthesis and organism engineering are already enabling substantial changes to organisms with megabase genomes, such as Escherichia coli and Saccharomyces cerevisiae. Simultaneously, recent advances in genome-scale modeling are increasingly informing the design of metabolic networks. However, major challenges remain for integrating these and other relevant technologies into workflows that can scale to the engineering of gigabase genomes. In particular, we find that a major under-recognized challenge is coordinating the flow of models, designs, constructs, and measurements across the large teams and complex technological systems that will likely be required for gigabase genome engineering. We recommend that the community address these challenges by 1) adopting and extending existing standards and technologies for representing and exchanging information at the gigabase genomic scale, 2) developing new technologies to address major open questions around data curation and quality control, 3) conducting fundamental research on the integration of modeling and design at the genomic scale, and 4) developing new legal and contractual infrastructure to better enable collaboration across multiple institutions.
MOESM3 of Optimisation: defining and exploring a concept to enhance the impact of public health initiatives
Creators: name: Wolfenden, Luke
name: Bolsewicz, Katarzyna
name: Grady, Alice
name: McCrabb, Sam
name: Kingsland, Melanie
name: Wiggers, John
name: Bauman, Adrian
name: Wyse, Rebecca
name: Nathan, Nicole
name: Sutherland, Rachel
name: Hodder, Rebecca
name: Fernandez, Maria
name: Lewis, Cara
name: Taylor, Natalie
name: McKay, Heather
name: Grimshaw, Jeremy
name: Hall, Alix
name: Moullin, Joanna
name: Albers, Bianca
name: Batchelor, Samantha
name: Attia, John
name: Milat, Andrew
name: Bailey, Andrew
name: Rissel, Chris
name: Reeves, Penny
name: Sims-Gould, Joanie
name: Mildon, Robyn
name: Doran, Chris
name: Sze Yoong
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Additional file 3. Conceptual map of 'Optimisation' derived from participant responses.
AVALIAÇÃO DA EFICIÊNCIA DO USO DE ÁGUA PELO TOMATEIRO SOB IRRIGAÇÃO POR SULCOS
Creators: name: Silveira, Jane Maria Carvalho
name: Daniel, Luiz Antonio
name: Matsura, Edson Eiji
name: Silveira, Jane Maria Carvalho
name: Daniel, Luiz Antonio
name: Matsura, Edson Eiji
Publisher: name: Unknown
Year: 2006
Subjects: subject: Crop Production/Industries
subject: Environmental Economics and Policy
subject: impactos ambientais
subject: recursos hídricos
subject: irrigação
subject: tomate
subject: percolação

description: A irrigação como a maior usuária de recursos hídricos necessita melhorar a eficiência do uso da água para produção de alimentos. Neste contexto, o objetivo do trabalho foi avaliar a eficiência do uso da água pela cultura do tomate sob irrigação por sulcos. O estudo foi realizado no Município de Estiva Gerbi/SP com o sistema de irrigação por sulcos conduzido por bandeira, o qual é amplamente utilizado na cultura de tomate. Os resultados mostraram que a eficiência de uso da água pela cultura do tomate foi baixa (3,3 kg.m-3), onde apenas 30% da água captada foi efetivamente utilizada pela cultura, e mais de 70% foi desperdiçado. Das perdas, o transporte de água até os talhões irrigados foi o principal responsável pelo desperdício. Foi constatada uma perda de água por percolação nos sulcos de irrigação ao redor de 80%. A alta perda por percolação foi conseqüência do dimensionamento e manejo inadequados deste sistema de irrigação por sulcos.
Completeness of Bethe ansatz for 1D Hubbard model with AB-flux through combinatorial formulas and exact enumeration of eigenstates
Creators: name: Nishino, Akinori
name: Deguchi, Tetsuo
Publisher: name: arXiv
Year: 2004
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: For the one-dimensional Hubbard model with Aharonov-Bohm-type magnetic flux, we study the relation between its symmetry and the number of Bethe states. First we show the existence of solutions for Lieb-Wu equations with an arbitrary number of up-spins and one down-spin, and exactly count the number of the Bethe states. The results are consistent with Takahashi's string hypothesis if the system has the so(4) symmetry. With the Aharonov-Bohm-type magnetic flux, however, the number of Bethe states increases and the standard string hypothesis does not hold. In fact, the so(4) symmetry reduces to the direct sum of charge-u(1) and spin-sl(2) symmetry through the change of AB-flux strength. Next, extending Kirillov's approach, we derive two combinatorial formulas from the relation among the characters of so(4)- or (u(1)\oplus sl(2))-modules. One formula reproduces Essler-Korepin-Schoutens' combinatorial formula for counting the number of Bethe states in the so(4)-case. From the exact analysis of the Lieb-Wu equations, we find that another formula corresponds to the spin-sl(2) case.
description: 26 pages, 6 figures
Computational assessment and in vitro test of phytochemicals of Usnea aciculifera as potential inhibitors of Escherichia coli efflux pump AcrB
Creators: name: Phan, Thien-Vy
name: Tuong, Lam-Truong
name: Nguyen, Vu-Thuy-Vy
name: Vo, Cam-Van T.
name: Tran, Thanh-Dao
name: Le, Minh-Tri
name: Nguyen, Bao Gia Dang
name: Tran, Van-Thanh
name: Vu, Thanh-Thao
name: Thai, Khac-Minh
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Lichens produce secondary metabolites that have many pharmaceutical activities such as antimicrobial, antioxidant, antiviral, anticancer, antigenotoxic, anti-inflammatory, analgesic and antipyretic activities. However, there is limited research on their efflux pump inhibitory activities. Twelve phytochemicals were isolated from Usnea aciculifera, and their activity of AcrAB-TolC efflux pump inhibition was evaluated. Four potential compounds, which are diffractaic acid (2), 8′ -O- methylstictic acid (5), 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 2,4-dimethoxy-3,6-dimethylbenzoate (8) and 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 2-hydroxy-4-methoxy-3,6-dimethylbenzoate (9), were found by virtual screening using pharmacophore and 2D-QSAR model. Compound 8 exhibited AcrB inhibition activity in vitro with an accumulation H33342 percentage compared with untreated control of 202% at a concentration of 50 µM and increased the antibacterial activity of levofloxacin by four-fold at a concentration of 200 µM. By molecular docking and molecular dynamics (MD) simulation, the binding affinity of depside and depsidone derivatives to AcrB was also clarified. Despite the poor docking score to the AcrB binding site, compound 8 was the most stable among the four complexes at 20 ns of MD simulation. The analysis of long MD at 100 ns indicated that compound 8 interacts strongly with the residues in the distal pocket, creating a stable complex with ΔGbind of −31.51 kcal.mol-1. According to the ADMETlab 2.0 web server’s predictions of pharmacokinetics and toxicities, compound 8 has the potential for drug development.
Symmetry of matrix-valued stochastic processes and noncolliding diffusion particle systems
Creators: name: Katori, Makoto
name: Tanemura, Hideki
Publisher: name: arXiv
Year: 2004
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: As an extension of the theory of Dyson's Brownian motion models for the standard Gaussian random-matrix ensembles, we report a systematic study of hermitian matrix-valued processes and their eigenvalue processes associated with the chiral and nonstandard random-matrix ensembles. In addition to the noncolliding Brownian motions, we introduce a one-parameter family of temporally homogeneous noncolliding systems of the Bessel processes and a two-parameter family of temporally inhomogeneous noncolliding systems of Yor's generalized meanders and show that all of the ten classes of eigenvalue statistics in the Altland-Zirnbauer classification are realized as particle distributions in the special cases of these diffusion particle systems. As a corollary of each equivalence in distribution of a temporally inhomogeneous eigenvalue process and a noncolliding diffusion process, a stochastic-calculus proof of a version of the Harish-Chandra (Itzykson-Zuber) formula of integral over unitary group is established.
description: LaTeX, 27 pages, 4 figures, v3: Minor corrections made for publication in J. Math. Phys
MUDANÇAS RECENTES NO EFEITO DA ESCOLARIDADE SOBRE O SALÁRIO DO TRABALHADOR AGRÍCOLA GAÚCHO
Creators: name: Stulp, Valter Jose
name: Stulp, Valter Jose
Publisher: name: Unknown
Year: 2006
Subjects: subject: Demand and Price Analysis
subject: Financial Economics
subject: Labor and Human Capital
subject: salários agrícolas
subject: agricultura gaúcha
subject: qualificação da mão de obra

description: O estudo analisa como o nível de escolaridade do trabalhador agrícola influencia a sua probabilidade de obter maiores salários dentro do setor agropecuário do Rio Grande do Sul e se houve mudanças nesta probabilidade no período de 1996 a 2002. Para esta análise são utilizados os dados da RAIS. Os resultados indicam que as chances de um trabalhador agrícola de auferir um salário acima de quatro salários mínimos somente se elevam se ele tem o 2o grau completo ou curso superior e que para dois salários mínimos é suficiente a 8a série completa. De 1996 a 2002 diminuíram as probabilidades de um trabalhador agrícola com uma escolaridade entre 4a série completa e 8a série incompleta de auferir qualquer nível de rendimento do trabalho acima de dois salários mínimos, mas não mudaram as chances dos trabalhadores com curso superior. Portanto, as mudanças tecnológicas que tenham ocorrido, neste período, na agricultura gaúcha, talvez ainda em função da liberalização econômica, requerem mão de obra mais qualificada, mas cujo nível de qualificação ainda não exija o curso superior.
p-adic etale cohomology of period domains
Creators: name: Colmez, Pierre
name: Dospinescu, Gabriel
name: Hauseux, Julien
name: Nizioł, Wiesława
Publisher: name: arXiv
Year: 2020
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We compute the p-torsion and p-adic etale cohomologies with compact support of period domains over local fields in the case of basic isocrystals for quasi-split reductive groups. For the p-torsion case, we follow the method used by Orlik in his computations of the l-torsion etale cohomology using as a key new ingredient the computation of Ext groups between mod p generalized Steinberg representations of p-adic groups. For the p-adic case, we don't use Huber's definition of etale cohomology with compact support as Orlik did since it seems to give spaces that are much too big; instead we use continuous etale cohomology with compact support.
description: published version
Perusal on the role of DMF solvent and hydrogen bonding in the formation of 1D polymeric chains in mixed ligand Ni(II) complex as an anticancer agent: a computational approach
Creators: name: Nagaraju, Maithra
name: Karthik, C. S.
name: Hema, M. K.
name: Chethan, B. S.
name: Ramalingam, R. Jothi
name: Karnan, Muthusamy
name: Lokanath, N. K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Computational Biology

description: A novel mixed ligand Ni(II) metal complex has been investigated for the modification in structural conformation, coordination bond, and noncovalent interactions. The novel Ni(II) metal complex [Ni(TFPB)2(1,10-Ph)(DMF)] has been synthesized and structurally characterized, which featured six coordination with three bidentate ligands connected through oxygen and nitrogen atoms. The single-crystal X-ray analysis showed that the compound possessed octahedral geometry and C-H…F, C-H…O, and π…π intermolecular interactions resulting in the formation of supramolecular architecture contributed significantly towards the crystal packing and molecular stability. Hirshfeld surface analysis was carried out to validate various intermolecular interactions. Further, the 3D structural topologies were visualized using energy framework analysis. To explore the coordination stability and chemically reactive parameters of the novel Ni(II) complex, the electronic structure was optimized using density functional theory calculations. The natural bond orbital analysis revealed the various hyperconjugative interactions exhibited by the complex. In addition, the complex was screened for in silico studies to understand the antitumoricidal potential of the novel Ni(II) complex. Molecular docking studies were also performed against three targeted proteins (PDB ID: 6H0W, 6NE5, and 6E91) to investigate the binding mode and protein–ligand interactions. These results are further analyzed by molecular dynamic simulation to confirm the best possible interactions and stability in the active site of the targeted proteins with a simulation period of 100 ns.
ANÁLISE DA EFICIÊNCIA DOS MERCADOS FUTUROS DE COMMODITIES AGRÍCOLAS BRASILEIRAS UTILIZANDO CO-INTEGRAÇÃO
Creators: name: Melo, Andre De Souza
name: Lima, Ricardo Chaves
name: Moraes, Andre Steffens
name: Melo, Andre De Souza
name: Lima, Ricardo Chaves
name: Moraes, Andre Steffens
Publisher: name: Unknown
Year: 2006
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: Mercados futuros
subject: commodities agrícolas
subject: eficiência de mercado
subject: co-integração
subject: prêmio ao risco

description: Este trabalho testa a presença de eficiência nos mercados futuros de boi gordo, açúcar cristal, milho e café negociados na Bolsa de Mercadorias de Futuros (BM&F), utilizando técnicas de cointegração. A eficiência de mercado é resultante de uma hipótese conjunta: dos preços futuros correntes serem preditores não viesados dos preços a vista no futuro e do prêmio ao risco ser nulo. Entretanto, a presença de prêmio ao risco é criada quando os agentes de mercado (investidores e produtores) demandam contratos futuros, visto que estes agentes são avessos ao risco. Com isso, objetiva-se analisar a existência de eficiência de mercado na presença de prêmio ao risco. O principal resultado é que os mercados de boi gordo, açúcar e milho se mostraram eficientes, ocorrendo convergência de longo prazo mesmo com presença de prêmio ao risco.
Arrival Distribution of Ultra-High Energy Cosmic Rays: Prospects for the Future
Creators: name: Yoshiguchi, Hiroyuki
name: Nagataki, Shigehiro
name: Sato, Katsuhiko
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We predict the arrival distribution of UHECRs above $4 \times 10^{19}$ eV with the event number expected by future experiments in the next few years. We perform event simulations with the source model which is adopted in our recent study and can explain the current AGASA observation. At first, we calculate the harmonic amplitude and the two point correlation function for the simulated event sets. We find that significant anisotropy on large angle scale will be observed when $\sim 10^3$ cosmic rays above $4 \times 10^{19}$ eV are detected by future experiments. The statistics of the two point correlation function will also increase. The angle scale at which the events have strong correlation with each other corresponds to deflection angle of UHECR in propagating in the EGMF, which in turn can be determined by the future observations. We further investigate the relation between the number of events clustered at a direction and the distance of their sources. Despite the limited amount of data, we find that the C2 triplet events observed by the AGASA may originate from the source within 100 Mpc. Merger galaxy Arp 299 (NGC 3690 + IC 694) is the best candidate for their source. If data accumulate, the UHECR sources within $\sim 100$ Mpc can be identified from observed event clusterings significantly. This will provide some kinds of information about poorly known parameters which influence the propagation of UHECRs, such as extragalactic and galactic magnetic field, chemical composition of observed cosmic rays. Also, we will reveal their origin with our method to identify the sources of UHECR. Finally, we predict the arrival distribution of UHECRs above $10^{20}$ eV, which is expected to be observed if the current HiRes spectrum is correct, and discuss their statistical features and implications.
description: 11 pages, 9 figures. accepted version for publication in ApJ
Estimating Input Cost Shares for Agriculture Using a Multinomial Logit Framework
Creators: name: LeBlanc, Michael
name: LeBlanc, Michael
Publisher: name: Unknown
Year: 1982
Subjects: subject: Production Economics
subject: Research Methods/ Statistical Methods
subject: Econometrics
subject: FOS: Economics and business
subject: limited dependent variable
subject: multinomial logit
subject: maximum likelihood

description: Many econometric analyses include dependent variables constrained to the interval between zero and 1 Under such conditions, simple regression procedures break down Several alternative stochastic models which avoid this problem can be defined depending on the assumed error structure Two alternative forms of the logit model are treated here The multivariate logit approach assumes that the share specification is an accurate representation of the underlying input demand structure The multinomial logit approach treats the dependent variable as a probability with a multinomial density
First-order magnetic phase-transition of mobile electrons in monolayer MoS$_2$
Creators: name: Roch, Jonas Gaël
name: Miserev, Dmitry
name: Froehlicher, Guillaume
name: Leisgang, Nadine
name: Sponfeldner, Lukas
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Klinovaja, Jelena
name: Loss, Daniel
name: Warburton, Richard John
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Evidence is presented for a first-order magnetic phase transition in a gated two-dimensional semiconductor, monolayer-MoS$_2$. The phase boundary separates a spin-polarised (ferromagnetic) phase at low electron density and a paramagnetic phase at high electron density. Abrupt changes in the optical response signal an abrupt change in the magnetism. The magnetic order is thereby controlled via the voltage applied to the gate electrode of the device. Accompanying the change in magnetism is a large change in the electron effective mass.
Excess mortality and risk factors for mortality among patients with severe mental disorders receiving home care case management
Creators: name: Chen, Wen-Yin
name: Sheng-Jean Huang
name: Chin-Kuo Chang
name: Chun-Hung Pan
name: Sheng-Shiang Su
name: Tien-Wei Yang
name: Chian-Jue Kuo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Home care case management (CM) is the main intervention for patients with severe mental disorders (SMDs) requiring outreach care. This study investigated the long-term mortality outcome and associated risk factors in patients who received home care CM. This nationwide study enrolled patients who received home care CM (n = 10,255) between 1 January 1999 and 31 December 2010. Each patient was followed up from the baseline (when patients underwent home case CM for the first time during the study period) to the censor (i.e. mortality or the end of the study). We calculated the standardized mortality ratio (SMR) and presented by age and diagnosis. Multivariate regression was performed to assess independent risk factors for mortality. Among 10,255 patients who received home care CM, 1409 died during the study period; the overall SMR was 3.13. Specifically, patients with organic mental disorder had the highest SMR (4.98), followed by those with schizophrenia (3.89), major depression (2.98), and bipolar disorder (1.97). In the multivariate analysis, patients with organic mental disorder or dementia had the highest risk, whereas the mortality risk in patients with schizophrenia was comparable to that in patients with bipolar disorder or major depression. Deceased patients had a significantly higher proportion of acute or chronic physical illnesses, including cancer, chronic hepatic disease, pneumonia, diabetes mellitus, cardiovascular disease, and asthma. This study presented the gap of mortality in patients with SMDs receiving home care CM in Taiwan. We highlight the need for effective strategies to improve medical care for this specified population.