title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÐ¼Ð° Ð² ÐºÐ°ÑÐºÐ°Ð´Ð°Ñ ÐºÐ¾Ð½ÑÑÑÐ¾Ð² Ñ Ð¿ÑÑÐ¼Ð¾Ð¹ ÑÐ²ÑÐ·ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Noise modeling in feed-forward loop cascades
Creators: name: ÐÑÐ½ Ð¡ÑÐ½ÑÑÐ¸Ð½ÑÐ»Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐºÐ¾Ð½ÑÑÑÐ° Ñ ÑÐ¿ÑÐµÐ¶ÐµÐ½Ð¸ÐµÐ¼(feed-forwardloop)
Ð¼ÐµÑÐ¾Ð´ ÐÐ¸Ð»Ð»ÐµÑÐ¿Ð¸
Ð¼Ð¸ÐºÑÐ¾Ð ÐÐ
ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐ°ÐºÑÐ¾ÑÑ(Ð¢Ð¤)
feed-forward loop(FFL)
Gillespie method
miRNAs
transcription factors (TFs)

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description: The aim of the work is to simulate the stochastic behavior of cascade loops with miRNAs using the Gillespie method, to evaluate the noise characteristics of the loops, to evaluate the degree of influence of upstream miRNA on the performance of downstream loops in the cascade, to evaluate the external noise, to compare two types of cascades. Small FFL have been well studied in the literature, but the analytical study of large loops presents a certain difficulty. The study showed that it is impossible to suppress the internal noise with a miRNA coming from another loop. Moreover, it only amplifies the internal noise in the system. Nevertheless, it was shown that when external noise is introduced into the system, its level in the proteins is lower than in the TF, which proves that the cascade suppresses external noise introduced into the TF. Conclusion: Cascade does not suppress internal noise, butit does suppress external noise.