cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MPEC 2024-G32 : 2023 FX54
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 FX54

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Lebensstil von Patienten mit überlebtem Herzinfarkt in Deutschland
Creators: name: Herrmann, Wolfram
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Aufgrund der verbesserten Therapie überleben zunehmend mehr Menschen in Deutschland einen akuten Herzinfarkt (aMI). Die Langzeitversorgung nach Herzinfarkt gewinnt daher zunehmend an Bedeutung, vor allem im hausärztlichen Setting. Bisher ist bekannt, dass die medikamentöse[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Numerical methods for piecewise deterministic Markov processes with boundary
Creators: name: Goudenège, Ludovic
Publisher: name: arXiv
Year: 2018
Subjects: subject: Analysis of PDEs (math.AP)
subject: Numerical Analysis (math.NA)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: In this paper is described the general aspect of a numerical method for piecewise determin-istic Markov processes with boundary. Under very natural hypotheses, a crucial result about uniqueness of solution of a generalized Kolmogorov equation with respect to a test function space is proved. Next we prove the existence and uniqueness of a positive solution to the finite volume scheme without result about convergence. Finally different models of transmission control protocol window-size processes are simulated to illustrate the efficiency of the numerical method for describing the evolution of the density of a piecewise deterministic Markov process with boundary. Obviously some technical aspects have been skipped for reader convenience but the full theory will be exposed in a forthcoming paper in collaboration with C.
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile-Induced Abdominal Aortic Aneurysm.
Creators: name: Kawai, Tatsuo
name: Takayanagi, Takehiko
name: Forrester, Steven J.
name: Preston, Kyle J.
name: Obama, Takashi
name: Tsuji, Toshiyuki
name: Kobayashi, Tomonori
name: Boyer, Michael J.
name: Cooper, Hannah A.
name: Kwok, Hang Fai
name: Hashimoto, Tomoki
name: Scalia, Rosario
name: Rizzo, Victor
name: Eguchi, Satoru
Publisher: name: Health Research Alliance
Year: 2019
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Angiotensin II (AngII)-activated epidermal growth factor receptor has been implicated in abdominal aortic aneurysm (AAA) development. In vascular smooth muscle cells (VSMCs), AngII activates epidermal growth factor receptor via a metalloproteinase, ADAM17 (a disintegrin and metalloproteinase domain 17). We hypothesized that AngII-dependent AAA development would be prevented in mice lacking ADAM17 in VSMCs. To test this concept, control and VSMC ADAM17-deficient mice were cotreated with AngII and a lysyl oxidase inhibitor, β-aminopropionitrile, to induce AAA. We found that 52.4% of control mice did not survive because of aortic rupture. All other surviving control mice developed AAA and demonstrated enhanced expression of ADAM17 in the AAA lesions. In contrast, all AngII and β-aminopropionitrile-treated VSMC ADAM17-deficient mice survived and showed reduction in external/internal diameters (51%/28%, respectively). VSMC ADAM17 deficiency was associated with lack of epidermal growth factor receptor activation, interleukin-6 induction, endoplasmic reticulum/oxidative stress, and matrix deposition in the abdominal aorta of treated mice. However, both VSMC ADAM17-deficient and control mice treated with AngII and β-aminopropionitrile developed comparable levels of hypertension. Treatment of C57Bl/6 mice with an ADAM17 inhibitory antibody but not with control IgG also prevented AAA development. In conclusion, VSMC ADAM17 silencing or systemic ADAM17 inhibition seems to protect mice from AAA formation. The mechanism seems to involve suppression of epidermal growth factor receptor activation.
Diffractive Dijet Production and Wigner Distributions from the Color Glass Condensate
Creators: name: Mäntysaari, Heikki
name: Mueller, Niklas
name: Schenke, Björn
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Experimental processes that are sensitive to parton Wigner distributions provide a powerful tool to advance our understanding of proton structure. In this work, we compute gluon Wigner and Husimi distributions of protons within the Color Glass Condensate framework, which includes a spatially dependent McLerran-Venugopalan initial configuration and the explicit numerical solution of the JIMWLK equations. We determine the leading anisotropy of the Wigner and Husimi distributions as a function of the angle between impact parameter and transverse momentum. We study experimental signatures of these angular correlations at a proposed Electron Ion Collider by computing coherent diffractive dijet production cross sections in e+p collisions within the same framework. Specifically, we predict the elliptic modulation of the cross section as a function of the relative angle between nucleon recoil and dijet transverse momentum for a wide kinematical range. We further predict its dependence on collision energy, which is dominated by the growth of the proton with decreasing $x$.
description: prefactors for longitudinal and transverse cross sections corrected, figures updated, typos corrected, 20 pages, 22 figures
MPEC 2024-G33 : 2023 FW54
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 FW54

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Advanced control laws for the new generation of AO systems
Creators: name: Correia, Carlos M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Geared by the increasing need for enhanced performance, both optical and computational, new dynamic control laws have been researched in recent years for next generation adaptive optics systems on current 10 m-class and extremely large telescopes up to 40 m. We provide an overview of these developments and point out prospects to making such controllers drive actual systems on-sky.
description: 11 pages, 2 colour figures
Sum Rule for the Optical Absorption of an Interacting Many-Polaron Gas
Creators: name: Tempere, J.
name: Devreese, J. T.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A sum rule for the first frequency moment of the optical absorption of a many-polaron system is derived, taking into account many-body effects in the system of constituent charge carriers of the many-polaron system. In our expression for the sum rule, the electron-phonon coupling and the many-body effects in the electron (or hole) system formally decouple, so that the many-body effects can be treated to the desired level of approximation by the choice of the dynamical structure factor of the electron (hole) gas. We calculate correction factors to take into account both low and high experimental cutoff frequencies.
description: 16 pages, 3 figures, revised version; new results added
Nonlinear optics with less than one photon
Creators: name: Resch, K. J.
name: Lundeen, J. S.
name: Steinberg, A. M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We demonstrate suppression and enhancement of spontaneous parametric down- conversion via quantum interference with two weak fields from a local oscillator (LO). Pairs of LO photons are observed to upconvert with high efficiency for appropriate phase settings, exhibiting an effective nonlinearity enhanced by at least 10 orders of magnitude. This constitutes a two-photon switch, and promises to be useful for a variety of nonlinear optical effects at the quantum level.
description: 8 pages, 5 figures
Possible Exotic Phases in the One-Dimensional Extended Hubbard Model
Creators: name: Clay, R. Torsten
name: Sandvik, Anders W.
name: Campbell, David K.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate numerically the ground state phase diagram of the one-dimensional extended Hubbard model, including an on--site interaction U and a nearest--neighbor interaction V. We focus on the ground state phases of the model in the V >> U region, where previous studies have suggested the possibility of dominant superconducting pairing fluctuations before the system phase separates at a critical value V=V_PS. Using quantum Monte Carlo methods on lattices much larger than in previous Lanczos diagonalization studies, we determine the boundary of phase separation, the Luttinger Liquid correlation exponent K_rho, and other correlation functions in this region. We find that phase separation occurs for V significantly smaller than previously reported. In addition, for negative U, we find that a uniform state re-enters from phase separation as the electron density is increased towards half filling. For V < V_PS, our results show that superconducting fluctuations are not dominant. The system behaves asymptotically as a Luttinger Liquid with K_rho < 1, but we also find strong low-energy (but gapped) charge-density fluctuations at a momentum not expected for a standard Luttinger Liquid.
description: 16 pages, 14 figures
MOESM2 of Detection of fetal trisomy and single gene disease by massively parallel sequencing of extracellular vesicle DNA in maternal plasma: a proof-of-concept validation
Creators: name: Zhang, Weiting
name: Lu, Sen
name: Pu, Dandan
name: Zhang, Haiping
name: Yang, Lin
name: Zeng, Peng
name: Su, Fengxia
name: Chen, Zhichao
name: Guo, Mei
name: Gu, Ying
name: Luo, Yanmei
name: Hu, Huamei
name: Lu, Yanping
name: Chen, Fang
name: Gao, Ya
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S2 Clinical information of the 20 euploid, 9â T21, 3â T18 and 1â T13 plasma of pregnancy women.
On the magnetic field in M51 ULX-8
Creators: name: Middleton, Matthew
name: Brightman, Murray
name: Pintore, Fabio
name: Bachetti, Matteo
name: Fabian, Andrew
name: Fuerst, Felix
name: Walton, Dominic
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The reported discovery of a cyclotron resonance scattering feature (CRSF) in the spectrum of M51 ULX-8 may provide an important clue as to the nature of the magnetic field in those ultraluminous X-ray sources hosting neutron stars. In this paper we present the covariance (linearly correlated variability) spectrum of M51 ULX-8 on long (> 2000s) timescales. This allows us to unambiguously decompose the spectrum which requires multiple components in order to explain the broad-band emission. Having a clearer picture of the spectral decomposition leads to various tests for the dipole field strength of the neutron star which can be extended to other ULXs when certain criteria are met. In the case of M51 ULX-8, we rule out a very strong (~10^15 G) dipole solution with either a sub- or super-critical disc. Instead, our tests indicate an upper limit on the dipole field of ~10^12 G, and a classical super-critical inflow, similar to that inferred in other ULXs found to harbour neutron stars, although we do not rule out the presence of an additional, strong (~10^15 G) multipole field falling off steeply with distance from the neutron star.
description: 9 pages, 4 figures, accepted to MNRAS, updated following corrections
Role of the PRC2-Six1-miR-25 signaling axis in heart failure.
Creators: name: Oh, Jae Gyun
name: Jang, Seung Pil
name: Jimeen Yoo
name: Min-Ah Lee
name: Lee, Seung Hee
name: Taejoong Lim
name: Jeong, Eden
name: Changwon Kho
name: Kook, Hyun
name: Hajjar, Roger J.
name: Park, Woo Jin
name: Dongtak Jeong
Publisher: name: Health Research Alliance
Year: 2019
Subjects: Cardiology

description: The reduced expression of cardiac sarco-endoplasmic reticulum Ca2+ ATPase (SERCA2a) is a hallmark of heartfailure. We previously showed that miR-25 is a crucial transcriptional regulator of SERCA2a in the heart.However, the precise mechanism of cardiac miR-25 regulation is largely unknown. Literatures suggested thatmiR-25 is regulated by the transcriptional co-factor, sine oculis homeobox homolog 1 (Six1), which in turn isepigenetically regulated by polycomb repressive complex 2 (PRC 2) in cardiac progenitor cells. Therefore, weaimed to investigate whether Six1 and PRC2 are indeed involved in the regulation of the miR-25 level in thesetting of heart failure. Six1 was up-regulated in the failing hearts of humans and mice. Overexpression of Six1led to adverse cardiac remodeling, whereas knock-down of Six1 attenuated pressure overload-induced cardiacdysfunction. The adverse effects of Six1 were ameliorated by knock-down of miR-25. The epigenetic repressionon the Six1 promoter by PRC2 was significantly reduced in failing hearts. Epigenetic repression of Six1 is relievedthrough a reduction of PRC2 activity in heart failure. Six1 up-regulates miR-25, which is followed byreduction of cardiac SERCA2a expression. Collectively, these data showed that the PRC2-Six1-miR-25 signalingaxis is involved in heart failure. Our finding introduces new insight into potential treatments of heart failure.
Controlling rotationally-resolved two-dimensional infrared spectra with polarization
Creators: name: Kowzan, Grzegorz
name: Allison, Thomas K.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Recent advancements in infrared frequency combs will enable recording of coherent two-dimensional infrared spectra of gas-phase molecules with rotational resolution (RR2DIR). We describe how RR2DIR spectra can be controlled with polarization to enhance or suppress certain features of the spectrum, with new polarization conditions unique to freely rotating molecules and absent in the condensed-phase. With the polarization control methods described here, RR2DIR spectroscopy can be a powerful tool for studying complex gas mixtures of polyatomic molecules.
description: updated references, minor clarification; 6 pages, 4 figures
title: Phonological milestones for African American English-speaking children learning Mainstream American English as a second dialect
Creators: name: Pearson, Barbara Zurer
name: Velleman, Shelley L
name: Bryant, Timothy J.
name: Charko, Tiffany
Publisher: name: University of Massachusetts Amherst
Year: 2009
Subjects: subject: speech and assessment
subject: multicultural issues
subject: evidence-based practice
subject: African American English

description: Purpose: This study provides milestones for phonological development in African American English (AAE) speakers who are learning Mainstream American English (MAE) as a second dialect. Method: The Dialect Sensitive Language Test (DSLT; H. Seymour, T. Roeper,&J.G. de Villiers, 2000) was administered to a nationwide sample of typically developing children ages 4 through 12: 537 speakers of AAE as a first dialect and 317 speakers of MAE as a first dialect. DSLT items tested all consonant segments and many clusters of MAE in initial and final position. The age at which each dialect group reached 90% criterion for each segment in each position was compared. Results: Several phonetic elements that are contrastive between the dialects (i.e., differentiate the dialects) in word-final position were found to be similar in the 2 groups in word-initial position. Only /ð/ was contrastive in both positions. We confirm the later acquisition of certain phonological segments and structures by AAE speakers compared to MAE speakers and report their earlier mastery of other elements of MAE phonology. Conclusion: Both segmental and phonotactic development show different trajectories for AAE and MAE. Thus, initial diagnosis of impairment for AAE children should focus only on mastery of noncontrastive segments and structures that share a similar developmental profile for the 2 dialect groups.
title: Prozessevaluation einer Interventionsstudie zur Verbesserung der Patient_innenversorgung durch Vernetzung und informierten Dialog – Accountable Care in Deutschland
Creators: name: Geiger, Isabel
name: Leve, Verena
name: Schüttig, Wiebke
name: Flemming, Ronja
name: Reddemann, Olaf
name: Hemming, Bernd
name: Gummersbach, Elisabeth
name: Wilm, Stefan
name: Sundmacher, Leonie
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: In der inter- sowie intrasektoralen Koordination der Versorgung von Patient_innen bestehen besondere Herausforderungen. In einer Interventionsstudie werden in der Versorgung zusammenarbeitende Akteure anhand von Routinedaten identifiziert und miteinander vernetzt. Die Intervention [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
title: Informationsbedürfnisse von Patienten mit geplanten bariatrischen Eingriffen aus Sicht von Ernährungsfachkräften – Ergebnisse eines Online-Surveys
Creators: name: Breuing, Jessica
name: Doni, Katharina
name: Pieper, Dawid
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Anzahl der bariatrischen Eingriffe in Deutschland steigt. Dabei zeigt sich die bariatrische Chirurgie im Vergleich zur konservativen Therapie als sehr effizient. Chirurgische Verfahren sind jedoch mit einschneidenden Konsequenzen für die Patienten verbunden wodurch ein gesteigertes[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Using Twitter Data to Understand Public Perceptions of Approved versus Off-label Use for COVID-19-related Medications
Creators: name: Hua, Yining
name: Jiang, Hang
name: Lin, Shixu
name: Yang, Jie
name: Plasek, Joseph M.
name: Bates, David W.
name: Zhou, Li
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computers and Society (cs.CY)
subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Understanding public discourse on emergency use of unproven therapeutics is crucial for monitoring safe use and combating misinformation. We developed a natural language processing-based pipeline to comprehend public perceptions of and stances on coronavirus disease 2019 (COVID-19)-related drugs on Twitter over time. This retrospective study included 609,189 US-based tweets from January 29, 2020, to November 30, 2021, about four drugs that garnered significant public attention during the COVID-19 pandemic: (1) Hydroxychloroquine and Ivermectin, therapies with anecdotal evidence; and (2) Molnupiravir and Remdesivir, FDA-approved treatments for eligible patients. Time-trend analysis was employed to understand popularity trends and related events. Content and demographic analyses were conducted to explore potential rationales behind people's stances on each drug. Time-trend analysis indicated that Hydroxychloroquine and Ivermectin were discussed more than Molnupiravir and Remdesivir, particularly during COVID-19 surges. Hydroxychloroquine and Ivermectin discussions were highly politicized, related to conspiracy theories, hearsay, and celebrity influences. The distribution of stances between the two major US political parties was significantly different (P < .001); Republicans were more likely to support Hydroxychloroquine (55%) and Ivermectin (30%) than Democrats. People with healthcare backgrounds tended to oppose Hydroxychloroquine (7%) more than the general population, while the general population was more likely to support Ivermectin (14%). Our study found that social media users have varying perceptions and stances on off-label versus FDA-authorized drug use at different stages of COVID-19. This indicates that health systems, regulatory agencies, and policymakers should design tailored strategies to monitor and reduce misinformation to promote safe drug use.
description: Full paper published in JAMIA
Inquiries into the Nature of Free Energy and Entropy in Respect to Biochemical Thermodynamics
Creators: name: Stoner, Clinton D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Physics Education (physics.ed-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Free energy and entropy are examined in detail from the standpoint of classical thermodynamics. The approach is logically based on the fact that thermodynamic work is mediated by thermal energy through the tendency for nonthermal energy to convert spontaneously into thermal energy and for thermal energy to distribute spontaneously and uniformly within the accessible space. The fact that free energy is a Second-Law, expendable energy that makes it possible for thermodynamic work to be done at finite rates is emphasized. Entropy, as originally defined, is pointed out to be the capacity factor for thermal energy that is hidden with respect to temperature; it serves to evaluate the practical quality of thermal energy and to account for changes in the amounts of latent thermal energies in systems maintained at constant temperature. A major objective was to clarify the means by which free energy is transferred and conserved in sequences of biological reactions coupled by freely diffusible intermediates. In achieving this objective it was found necessary to distinguish between a 'characteristic free energy' possessed by all First-Law energies in amounts equivalent to the amounts of the energies themselves and a 'free energy of concentration' that is intrinsically mechanical and relatively elusive in that it can appear to be free of First-Law energy. The findings in this regard serve to clarify the fact that the transfer of chemical potential energy from one repository to another along sequences of biological reactions of the above sort occurs through transfer of the First-Law energy as thermal energy and transfer of the Second-Law energy as free energy of concentration.
description: 18-page PDF; major correction in APPENDIX; minor corrections elsewhere
title: Situationsanalyse Partner*innen-Benachrichtigung zu sexuell übertragbaren Infektionen (STI) in Deutschland
Creators: name: Enders, Kristina
name: Schu, Martina
name: Eisenbach, Katharina
name: Tossmann, Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Weltweit sind Partner*innen-Benachrichtigung (PB) und zum Teil auch Partner Notification wichtige Bestandteile der Maßnahmen zur Bekämpfung von sexuell übertragbaren Krankheiten. Allerdings gibt es erhebliche Unterschiede in der Art und Weise, wie PB umgesetzt wird.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Analytical operator solution of master equations describing phase-sensitive processes
Creators: name: Vidiella-Barranco, A.
name: Arevalo-Aguilar, Luis M.
name: Moya-Cessa, H.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a method of solving master equations which may describe, in their most general form, phase sensitive processes such as decay and amplification. We make use of the superoperator technique.
description: 10 pages, LaTex, 3 figures, accepted for publication in International Journal of Modern Physics B
Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions
Creators: name: Majtan, Tomas
name: Pey, Angel L.
name: Ereno-Orbea, June
name: Martínez-Cruz, Luis Alfonso
name: Kraus, Jan P.
Publisher: name: Health Research Alliance
Year: 2019
Subjects: subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: FOS: Biological sciences
subject: Genetics
subject: Medicine
subject: Molecular Biology

description: Classical homocystinuria (HCU) is the most common loss-of-functioninborn error of sulfur amino acids metabolism. HCU is caused by a deficiency inenzymatic degradation of homocysteine, a toxic intermediate of methionine transformationto cysteine, chiefly due to missense mutations in the cystathionine betasynthase(CBS) gene. As with many other inherited disorders, the pathogenic mutationsdo not target key catalytic residues, but rather introduce structural perturbationsleading to an enhanced tendency of the mutant CBS to misfold and either toform non-functional aggregates or to undergo proteasome-dependent degradation.Thus correction of CBS misfolding represents an alternative therapeutic approachfor HCU. In this review, we summarize the complex nature of CBS, its multidomainarchitecture, the interplay between the three cofactors required for CBS function (heme, pyridoxal-5’-phosphate (PLP) and S-adenosyl-L-methionine) as well as the intricate allosteric regulatorymechanism only recently explained thanks to advances in CBS crystallography. While roughly half ofthe patients responds to treatment with a PLP precursor pyridoxine, many studies suggested usefulnessof small chemicals, such as chemical and pharmacological chaperones or proteasome inhibitors,rescuing mutant CBS activity in cellular and animal models of HCU. Non-specific chemical chaperonesand proteasome inhibitors assist in mutant CBS folding process and/or prevent its rapid degradation,thus resulting in increased steady state levels of the enzyme and CBS activity. Recent increasedinterest in the field and available structural information will hopefully yield CBS-specific compoundsby using high-throughput screening and computational modeling of novel ligands improving folding,stability and activity of CBS.
Optical Absorption of an Interacting Many-Polaron Gas
Creators: name: Tempere, J.
name: Devreese, J. T.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The optical absorption of a many (continuum) polaron gas is derived in the framework of a variational approach at zero temperature and weak or intermediate electron-phonon coupling strength. We derive a compact formula for the optical conductivity of the many-polaron system taking into account many-body effects in the electron or hole system. Within the method presented here, these effects are contained completely in the dynamical structure factor of the electron or hole system. This allows to build on well-established studies of the interacting electron gas. Based on this approach a novel feature in the absorption spectrum of the many-polaron gas, related to the emission of a plasmon together with a phonon, is identified. As an application and illustration of the technique, we compare the theoretical many-polaron optical absorption spectrum as derived in the present work with the `d-band' absorption feature in Nd$_{2}$CuO$_{2}$. Similarities are shown between the theoretically and the experimentally derived first frequency moment of the optical absorption of a family of differently doped Nd$_{2-x}$Ce$_{x}$CuO$_{4-y}$ materials.
description: 24 pages, 5 figures; revised and expanded version
Cellular Automata
Creators: name: Bagnoli, Franco
Publisher: name: arXiv
Year: 1998
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: An introduction to cellular automata (both deterministic and probabilistic) with examples. Definition of deterministic automata, dynamical properties, damage spreading and Lyapunov exponents; probabilistic automata and Markov processes, nonequilibrium phase transitions, directed percolation, diffusion; simulation techniques, mean field. Investigation themes: life, epidemics, forest fires, percolation, modeling of ecosystems and speciation. They represent my notes for the school "Dynamical Modeling in Biotechnologies", ISI, Villa Gualino 1996.
description: 40 pages and 23 figures
miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy.
Creators: name: Oh, Jae Gyun
name: Watanabe, Shin
name: Ahyoung Lee
name: Gorski, Przemek A.
name: Philyoung Lee
name: Dongtak Jeong
name: Lifan Liang
name: Yaxuan Liang
name: Baccarini, Alessia
name: Sahoo, Susmita
name: Brown, Brian D
name: Hajjar, Roger J.
name: Changwon Kho
Publisher: name: Health Research Alliance
Year: 2019
Subjects: Cardiology

description: Rationale: Abnormal SUMOylation has emerged as a characteristic of heart failure (HF) pathology. Previously,we found reduced SUMO1 (small ubiquitin-like modifier 1) expression and SERCA2a (sarcoplasmic reticulumCa2+-ATPase) SUMOylation in human and animal HF models. SUMO1 gene delivery or small molecule activationof SUMOylation restored SERCA2a SUMOylation and cardiac function in HF models. Despite the critical role ofSUMO1 in HF, the regulatory mechanisms underlying SUMO1 expression are largely unknown.Objective: To examine miR-146a–mediated SUMO1 regulation and its consequent effects on cardiac morphologyand function.Methods and Results: In this study, miR-146a was identified as a SUMO1-targeting microRNA in the heart. A strongcorrelation was observed between miR-146a and SUMO1 expression in failing mouse and human hearts. miR-146awas manipulated in cardiomyocytes through AAV9 (adeno-associated virus serotype 9)-mediated gene delivery,and cardiac morphology and function were analyzed by echocardiography and hemodynamics. Overexpression ofmiR-146a reduced SUMO1 expression, SERCA2a SUMOylation, and cardiac contractility in vitro and in vivo. Theeffects of miR-146a inhibition on HF pathophysiology were examined by transducing a tough decoy of miR-146ainto mice subjected to transverse aortic constriction. miR-146a inhibition improved cardiac contractile functionand normalized SUMO1 expression. The regulatory mechanisms of miR-146a upregulation were elucidated byexamining the major miR-146a–producing cell types and transfer mechanisms. Notably, transdifferentiation offibroblasts triggered miR-146a overexpression and secretion through extracellular vesicles, and the extracellularvesicle–associated miR-146a transfer was identified as the causative mechanism of miR-146a upregulation in failingcardiomyocytes. Finally, extracellular vesicles isolated from failing hearts were shown to contain high levels of miR-146a and exerted negative effects on the SUMO1/SERCA2a signaling axis and hence cardiomyocyte contractility.Conclusions: Taken together, our results show that miR-146a is a novel regulator of the SUMOylation machineryin the heart, which can be targeted for therapeutic intervention.
Fast radio bursts as synchrotron maser emission from decelerating relativistic blast waves
Creators: name: Metzger, Brian D.
name: Margalit, Ben
name: Sironi, Lorenzo
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Fast radio bursts (FRB) can arise from synchrotron maser emission at ultra-relativistic magnetized shocks, such as produced by flare ejecta from young magnetars. We combine PIC simulation results for the synchrotron maser with the dynamics of self-similar shock deceleration, as commonly applied to GRBs, to explore the implications for FRB emission. We assume the upstream environment into which the ultra-relativistic ejecta collides is a mildly relativistic baryon-loaded shell released following a previous flare, motivated by the high electron-ion injection rate Mdot ~ 1e19-1e21 g/s needed on larger scales to power the persistent radio nebula coincident with the repeating burster FRB 121102 and its high inferred rotation measure. The observed radio fluence peaks once the optical depth ahead of the shock to induced Compton scattering decreases to ~ 1e5 s between major ion-injection events needed to clear sufficiently low densities around the engine for FRB emission could explain prolonged "dark" periods and clustered burst arrival times, and lead to stochastic variation in the dispersion measure. Thermal electrons heated at the shock generate a short-lived
description: 15 pages, 8 figures, accepted to MNRAS after minor revisions
Est-ce que les ressources éducatives libres (REL) peuvent nous faire sauver du temps?
Creators: name: Bourque, Marilou
name: Potvin, Claude
Publisher: name: Université Laval
Year: 2024
Subjects: Ressources éducatives libres
Éducation ouverte

description: Cette présentation tente d'abord d'expliquer ce qu'est une ressource éducative libre (REL) et en quoi consiste le mouvement de l'éducation ouverte. On analyse ensuite ensemble la question du temps accordé à la création de nos ressources éducatives :

Est-ce qu'une REL prend plus de temps à créer qu'une ressource éducative standard?

Qu'est-ce qui demande du temps dans la création de ressources éducatives? 

Est-ce que le temps, c’est de l’argent, et si oui, qui encaisse?

Qu’en est-il du temps versus la qualité des ressources produites?

Qu'entend-on par document "vivant" quand on parle de REL?

Au final, est-ce que la question du temps est la bonne question à se poser?

Enfin, le webinaire nous permet de prendre connaissance de la perspective sur les REL et le temps de 2 personnes créatrices de REL à l'Université Laval, la professeure titulaire à la Faculté de droit, Marie-Claire Belleau, et le conseiller en pédagogie universitaire Jean-François Proteau.

Pour visualiser la vidéo dans Youtube : https://youtu.be/xcqCCEQIoDk?si=Mzwr_qkdwm9O6JQw
description: Ressources éducatives libres

Open educational resources

REL

OER
description: Discipline : Éducation

Format : Texte; Vidéo

Type de la ressource : Objet d'apprentissage

Type de matériel pédagogique : Présentation
MOESM1 of Disruption of a putative mitochondrial oxaloacetate shuttle protein in Aspergillus carbonarius results in secretion of malic acid at the expense of citric acid production
Creators: name: Yang, Lei
name: Linde, Tore
name: Hossain, Abeer
name: LĂźbeck, Mette
name: Punt, Peter
name: LĂźbeck, Peter
Publisher: name: figshare
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. Transcriptional analysis of the mtpA gene.
Hamiltonisation, measure preservation and first integrals of the multi-dimensional rubber Routh sphere
Creators: name: García-Naranjo, Luis C.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 37J60, 70F25, 70G45

description: We consider the multi-dimensional generalisation of the problem of a sphere, with axi-symmetric mass distribution, that rolls without slipping or spinning over a plane. Using recent results from García-Naranjo (arXiv: 1805:06393) and García-Naranjo and Marrero (arXiv: 1812.01422), we show that the reduced equations of motion possess an invariant measure and may be represented in Hamiltonian form by Chaplygin's reducing multiplier method. We also prove a general result on the existence of first integrals for certain Hamiltonisable Chaplygin systems with internal symmetries that is used to determine conserved quantities of the problem.
description: 23 pages, 1 figure. Submitted to the special issue of Theor. Appl. Mech. in honour of Chaplygin's 150th anniversary
PST: Plant segmentation transformer for 3D point clouds of rapeseed plants at the podding stage
Creators: name: Du, Ruiming
name: Ma, Zhihong
name: Xie, Pengyao
name: He, Yong
name: Cen, Haiyan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Segmentation of plant point clouds to obtain high-precise morphological traits is essential for plant phenotyping. Although the fast development of deep learning has boosted much research on segmentation of plant point clouds, previous studies mainly focus on the hard voxelization-based or down-sampling-based methods, which are limited to segmenting simple plant organs. Segmentation of complex plant point clouds with a high spatial resolution still remains challenging. In this study, we proposed a deep learning network plant segmentation transformer (PST) to achieve the semantic and instance segmentation of rapeseed plants point clouds acquired by handheld laser scanning (HLS) with the high spatial resolution, which can characterize the tiny siliques as the main traits targeted. PST is composed of: (i) a dynamic voxel feature encoder (DVFE) to aggregate the point features with the raw spatial resolution; (ii) the dual window sets attention blocks to capture the contextual information; and (iii) a dense feature propagation module to obtain the final dense point feature map. The results proved that PST and PST-PointGroup (PG) achieved superior performance in semantic and instance segmentation tasks. For the semantic segmentation, the mean IoU, mean Precision, mean Recall, mean F1-score, and overall accuracy of PST were 93.96%, 97.29%, 96.52%, 96.88%, and 97.07%, achieving an improvement of 7.62%, 3.28%, 4.8%, 4.25%, and 3.88% compared to the second-best state-of-the-art network PAConv. For instance segmentation, PST-PG reached 89.51%, 89.85%, 88.83% and 82.53% in mCov, mWCov, mPerc90, and mRec90, achieving an improvement of 2.93%, 2.21%, 1.99%, and 5.9% compared to the original PG. This study proves that the deep-learning-based point cloud segmentation method has a great potential for resolving dense plant point clouds with complex morphological traits.
description: 46 pages, 10 figures
Congruence Kinematics in Conformal Gravity
Creators: name: Fathi, Mohsen
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: In this paper we calculate the kinematical quantities of the Raychaudhuri equations, to characterize a congruence of time-like integral curves, according to the vacuum radial solution of Weyl theory of gravity. Also the corresponding flows are plotted for definite values of constants.
description: 10 pages, 3 figures
Measuring Cardiomyocyte Contractility and Calcium Handling In Vitro.
Creators: name: Gorski, Przemek A.
name: Changwon Kho
name: Oh, Jae Gyun
Publisher: name: Health Research Alliance
Year: 2019
Subjects: Cardiology

description: In vitro measurements of cardiomyocyte contractility and Ca2+ handling have been used as a platform fordetermining physiological consequence of various genetic manipulations and identifying potential therapeutictargets for the treatment of heart failure. The Myocyte Calcium and Contractility System (IonOptix)offers a simultaneous trace of sarcomere movements and changes of intracellular Ca2+ levels in a singlecardiomyocyte. Herein, we describe a modified protocol for the isolation of adult cardiomyocytes frommurine hearts and provide a step-by-step description on how to analyze cardiomyocyte Ca2+ transient andcontractility data collected using the IonOptix system. In our modified protocol, we recommend a novelcannulation technique which simplifies this difficult method and leads to improved viability of isolatedcardiomyocytes. In addition, a comprehensive analysis of intracellular Ca2+ handling, SR Ca2+ load,myofilament Ca2+ sensitivity, and cardiomyocyte contractility is described in order to provide importantinsights into myocardial mechanics.
Experimental Models of Cardiovascular Diseases
Creators: name: Oh, Jae Gyun
name: Ishikawa, Kiyotake
Publisher: name: Health Research Alliance
Year: 2019
Subjects: Cardiology

description: Cardiovascular disease is one of the most common causes of deaths in clinics. Experimental models ofcardiovascular diseases are essential to understand disease mechanism, to provide accurate diagnoses, and todevelop new therapies. Large numbers of experimental models have been proposed and replicated by manylaboratories in the past. Models with significant advantages are chosen and became more popular. Particularly,feasibility, reproducibility, and human disease resemblance are the common key factors for frequentlyused cardiovascular disease models. In this chapter, we provide a brief overview of these experimentalmodels used for in vitro, in vivo, and in silico studies of cardiovascular diseases.
title: Patientenzentrierte Versorgung im letzten Lebensjahr: Adaptierung und Validierung einer PACIC-Kurzversion für Nahestehende
Creators: name: Vennedey, Vera
name: Hanke, Gloria
name: Schippel, Nicolas
name: Shukri, Arim
name: Strupp, Julia
name: Rietz, Christian
name: Voltz, Raymond
name: Stock, Stephanie
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Versorgung von Patient*innen in ihrem letzten Lebensjahr stellt besondere Anforderungen an die patientenzentrierte Ausgestaltung der Versorgung. Beispielsweise ist die Morbidität der Patient*innen sehr hoch, die Inanspruchnahme von Gesundheitsleistungen im letzten Lebensjahr[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Quantifying Chemical Structure and Atomic Energies in Amorphous Silicon Networks
Creators: name: Bernstein, Noam
name: Bhattarai, Bishal
name: Csányi, Gábor
name: Drabold, David A.
name: Elliott, Stephen R.
name: Deringer, Volker L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Amorphous materials are coming within reach of realistic computer simulations, but new approaches are needed to fully understand their intricate atomic structures. Here, we show how machine-learning (ML)-based techniques can give new, quantitative chemical insight into the atomic-scale structure of amorphous silicon (a-Si). Based on a similarity function ("kernel"), we define a structural metric that unifies the description of nearest- and next-nearest-neighbor environments in the amorphous state. We apply this to an ensemble of a-Si networks, generated in melt-quench simulations with an ML-based interatomic potential, in which we tailor the degree of ordering by varying the quench rates down to $10^{10}$ K/s (leading to a structural model that is lower in energy than the established WWW network). We then show how "machine-learned" atomic energies permit a chemical interpretation, associating coordination defects in a-Si with distinct energetic stability regions. The approach is straightforward and inexpensive to apply to arbitrary structural models, and it is therefore expected to have more general significance for developing a quantitative understanding of the amorphous state.
Phenomenological model of high-Tc superconductivity
Creators: name: Mourachkine, A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a phenomenological model of high-Tc superconductivity in hole-doped cuprates: a Magnetic Coupling between Stripes (MCS) model. The MCS model is based upon experimental facts, namely, the presence of (i) stripes, (ii) spin fluctuations, and (iii) two order parameters (for pairing and long-range phase coherence) in hole-doped cuprates. We discuss also the superconductivity in electron-doped cuprates.
description: 2 pages, will appear in Physica C (proceedings of M2S-HTSC-VI Conference in Houston); see also cond-mat/9910449
How Routing Strategies Impact Urban Emissions
Creators: name: Cornacchia, Giuliano
name: Böhm, Matteo
name: Mauro, Giovanni
name: Nanni, Mirco
name: Pedreschi, Dino
name: Pappalardo, Luca
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computers and Society (cs.CY)
subject: Multiagent Systems (cs.MA)
subject: FOS: Computer and information sciences

description: Navigation apps use routing algorithms to suggest the best path to reach a user's desired destination. Although undoubtedly useful, navigation apps' impact on the urban environment (e.g., carbon dioxide emissions and population exposure to pollution) is still largely unclear. In this work, we design a simulation framework to assess the impact of routing algorithms on carbon dioxide emissions within an urban environment. Using APIs from TomTom and OpenStreetMap, we find that settings in which either all vehicles or none of them follow a navigation app's suggestion lead to the worst impact in terms of CO2 emissions. In contrast, when just a portion (around half) of vehicles follow these suggestions, and some degree of randomness is added to the remaining vehicles' paths, we observe a reduction in the overall CO2 emissions over the road network. Our work is a first step towards designing next-generation routing principles that may increase urban well-being while satisfying individual needs.
BCS Theory for Trapped Ultracold Fermions
Creators: name: Bruun, G.
name: Castin, Y.
name: Dum, R.
name: Burnett, K.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We develop an extension of the well-known BCS-theory to systems with trapped fermions. The theory fully includes the quantized energy levels in the trap. The key ingredient is to model the attractive interaction between two atoms by a pseudo-potential which leads to a well defined scattering problem and consequently a BCS-theory free of divergences. We present numerical results for the BCS critical temperature and the temperature dependence of the gap. They are used as a test of existing semi-classical approximations.
description: 4 pages, 3 figures, submitted to PRL