cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Microscydmus
Creators: name: Jałoszyński, Paweł
name: Perkovsky, Evgeny
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Microscydmus

description: ? Microscydmus sp. 2
(Figs 30, 204–208)
Material studied. Late Eocene of Europe, Rovno amber: sex unknown; inclusion in elongate, subtrapezoidal prism of amber 14 mm long (Fig. 30), collection number K-6943 (SIZK).
Description. Body (Figs 204–208) elongate, moderately slender and convex, light brown; BL 0.73 mm.
Head (Figs 204–208) short and subhexagonal, broadest at eyes, HL 0.13 mm, HW 0.19 mm; vertex (Fig. 207; vt) and frons (Fig. 207; fr) confluent, weakly convex and together subhexagonal, strongly transverse; eyes large, oval, strongly convex; tempora in lateral view (Fig. 208) distinctly shorter than eyes. Punctures and setae on frons and vertex poorly visible. Antennae (Figs 204–208) distinctly shorter than half BL, AnL about 0.25 mm, scape and pedicel strongly elongate, antennomeres III–VII each about as long as broad or slightly elongate, VIII slightly elongate, X about as long as broad, XI slightly transverse, XI much shorter than IX–X combined, about 1.2 × as long as broad, slightly narrower than X and rounded at apex.
Pronotum (Figs 204, 207) round, broadest near anterior third; PL 0.20 mm, PW 0.20 mm; anterior and posterior margins weakly arcuate, anterior and posterior pronotal corners broadly obtuse-angled and blunt; sides strongly rounded; antebasal structures poorly visible. Punctures and setae on pronotal disc poorly visible.
Elytra (Figs 204–205, 207–208) elongate oval, moderately convex, EL 0.40 mm, EW 0.30 mm, EI 1.33; punctures (Fig. 208) fine but discernible, separated by spaces 3–4 × as wide as diameters of punctures; setae (Fig. 208) sparse, short, suberect.
Legs (Figs 205–206, 208) moderately long, slender, unmodified.
Remarks. This small specimen is tentatively identified as Microscydmus, but too few important structures are observable to confirm this placement.
description: Published as part of Jałoszyński, Paweł & Perkovsky, Evgeny, 2016, Diversity of Scydmaeninae (Coleoptera: Staphylinidae) in Upper Eocene Rovno amber, pp. 1-85 in Zootaxa 4157 (1) on pages 68-69, DOI: 10.11646/zootaxa.4157.1.1, http://zenodo.org/record/262413
Co-ordinated regulation of pathways controlling chlamydial virulence and stress response
Creators: name: Omesi, Samuel Y
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Chlamydia trachomatis is an obligate intracellular bacterium responsible for an estimated 127 million annual genital infections worldwide. Though disease symptoms are dependent upon chlamydial infection, the factors behind chlamydial disease outcomes are poorly understood. C. trachomatis possesses a highly conserved plasmid containing the virulence gene pgp3 as well as the global regulator pgp4, which regulates the expression of multiple genes including the glycogen synthase gene glgA. Expression of these genes is reduced when glucose is limited as is transcription of omcA, a plasmid-independent gene that encodes a key component of the chlamydial cell envelope. A similar regulatory pathway is active in the murine-adapted pathogen Chlamydia muridarum, although the response to low glucose availability is not conserved. The principal aim of this research was to investigate the regulatory hierarchy of Pgp4 and environmental stress to better understand mechanisms modulating chlamydial virulence during human infection.

To study the impact of the regulator Pgp4 on virulence factors in the plasmid of C. trachomatis, inducible plasmids were generated and gene expression was measured via fluorescent microscopy and glycogen staining. Environmental regulation was observed via glucose washout, as well as the addition of the glucose competitor 2-deoxyglucose (2DG),which chlamydia is unable to metabolize. Finally,stress conditions beyond glucose limitation were introduced to determine which conditions of stress induce similar responses.  Our research indicated that pgp4 served a regulatory role in the expression of pgp3 and glgA, however genetic regulation response to glucose limitation was cis-acting within the promoters glgA and omcA, suggesting multiple levels of regulation of virulence.  This research emphasizes that C.trachomatis is in a constant condition of stress within human epithelial systems, as the human immune system introduces conditions of stress.  Overall,this research confirms a model of regulatory complexity and environmental sensing while showcasing the host-dependence as it applies to glucose parasitism in the C. trachomatis system.
Dilations of CP-maps commuting according to a graph
Creators: name: Vernik, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 46L55, 46L57, 46L08

description: We study dilations of finite tuples of normal, completely positive and completely contractive maps (which we call CP-maps) acting on a von Neumann algebra, and commuting according to a graph G. We show that if G is acyclic, then a tuple commuting according to it has a simultaneous *-endomorphic dilation, which also commutes according to G. Conversely, if G has a cycle, we exhibit an example of a tuple of CP-maps commuting according to G, which does not have an *-endomorphic dilation commuting according to G. To achieve these results we use dilation theory of representations of subproduct systems, as introduced and studied by Shalit and Solel. In the course of our investigations we also prove some results about those kinds of subproduct systems which arise from CP-maps commuting according to to a graph.
description: 30 pages
Validity of the single-particle description and charge noise resilience for multielectron quantum dots
Creators: name: Bakker, Michiel A.
name: Mehl, Sebastian
name: Hiltunen, Tuukka
name: Harju, Ari
name: DiVincenzo, David P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We construct an optimal set of single-particle states for few-electron quantum dots (QDs) using the method of natural orbitals (NOs). The NOs include also the effects of the Coulomb repulsion between electrons. We find that they agree well with the noniteracting orbitals for GaAs QDs of realistic parameters, while the Coulomb interactions only rescale the radius of the NOs compared to the noninteracting case. We use NOs to show that four-electron QDs are less susceptible to charge noise than their two-electron counterparts.
description: 11+ pages, 5 figures
Modeling Populations of Thermostatic Loads with Switching Rate Actuation
Creators: name: Totu, Luminita Cristiana
name: Wisniewski, Rafael
name: Leth, John
Publisher: name: arXiv
Year: 2014
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We model thermostatic devices using a stochastic hybrid description, and introduce an external actuation mechanism that creates random switch events in the discrete dynamics. We then conjecture the form of the Fokker-Planck equation and successfully verify it numerically using Monte Carlo simulations. The actuation mechanism and subsequent modeling result are relevant for power system operation.
description: In Proceedings HAS 2014, arXiv:1501.05405
"Ich will dich lieben, meine Stärke"
Creators: name: Kapellari, Egon
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 2 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 2
Evaluating the efficacy of EFTX-016 ASO in inhibiting the most prevalent lung cancer KRAS mutations
Creators: name: Im, Jonah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Antisense oligonucleotides (ASOs) regulate cellular gene expression by hybridizing to a complementary RNA sequence and subsequently activating the RNase H1 degradation pathway. Recent advances in oligomer chemical modifications have paved the way for next-generation ASOs with much greater stability in vivo, showing great potential for ASOs as a cancer therapeutic. EFTX-016 ASO is a selective and potent ASO sequence currently under development and designed to knockdown mutant KRAS expression for cancer treatment. In this study, we characterize the efficacy of a screen of variously modified EFTX-016 ASOs to downregulate KRAS mRNA in representative cancer cell lines. We found that free-uptake of the pan-KRAS EFTX-016 ASO sequence (ASO16), which simultaneously targets the four most common KRAS mutations (G12C, G12V, G12D, and G13D), much less potently knocks down KRAS mRNA than the G12C mutant-specific EFTX-016 ASO sequence (ASO16-G12C). Further modifying ASO16-G12C with locked nucleic acid(s) (LNAs) significantly reduced G12C mutant KRAS expression in vitro while moderately sparing wild type activity. Future studies aim to uncover the clinical potential of the ASO16-G12C sequence by continuing to improve its KRAS knockdown efficiency in vitro, wild type KRAS sparing capacity, and evaluating its ability to modulate growth in lung tumor microenvironments.
A Strategy to Minimize Dust Foregrounds in B-mode Searches
Creators: name: Kovetz, Ely D.
name: Kamionkowski, Marc
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Planck satellite has identified several patches of sky with low polarized dust emission, obvious targets for searches for the cosmic-microwave-background (CMB) B-mode signal from inflationary gravitational waves. Still, given the Planck measurement uncertainties, the polarized dust foregrounds in these different candidate patches may differ by an order of magnitude or more. Here we show that a brief initial experiment to map these candidate patches more deeply at a single high frequency can efficiently zero in on the cleanest patch(es) and thus improve significantly the sensitivity of subsequent B-mode searches. A ground-based experiment with current detector technology operating at >~220 GHz for 3 months can efficiently identify a low-dust-amplitude patch and thus improve by up to a factor 2 or 3 on the sensitivity to cosmic B modes of the subsequent lower-frequency deep integration. A balloon experiment with current detector sensitivities covering the set of patches and operating at ~350 GHz can reach a similar result in less than two weeks. This strategy may prove crucial in accessing the smallest gravitational-wave signals possible in large-field inflation. The high-frequency data from this exploratory experiment should also provide valuable foreground templates to subsequent experiments that integrate on any of the candidate patches explored.
description: 6 pages, 1 figure; clarifications added; version accepted as rapid communication in PRD
Mexican children's perception of cultural specificity in American cartoons
Creators: name: Cornelio Marí, Elia Margarita
Publisher: name: The University of Texas at Austin
Year: 2005
Subjects: Animation studies
Cultural imperialism
Mexican children

description: This thesis combines elements of industrial and textual analysis along with reception studies to explore how children from Tabasco, Mexico, perceive cultural specificity in the American animated series Dexter’s Laboratory. The basic objective is to study the ways in which an American text distributed internationally is perceived by a local audience, particularly by one that is in the process of construction of its cultural identity. The results present a complex picture of the reception moment, showing that children apply diverse strategies to make sense of culturally distant references in the cartoon. Issues of cultural adaptation and international trade of animation are also addressed
The VLT-FLAMES Tarantula Survey XIX. B-type Supergiants - Atmospheric parameters and nitrogen abundances to investigate the role of binarity and the width of the main sequence
Creators: name: McEvoy, C. M.
name: Dufton, P. L.
name: Evans, C. J.
name: Kalari, V. M.
name: Markova, N.
name: Simón-Díaz, S.
name: Vink, J. S.
name: Walborn, N. R.
name: Crowther, P. A.
name: de Koter, A.
name: de Mink, S. E.
name: Dunstall, P. R.
name: Hénault-Brunet, V.
name: Herrero, A.
name: Langer, N.
name: Lennon, D. J.
name: Apellániz, J. Maíz
name: Najarro, F.
name: Puls, J.
name: Sana, H.
name: Schneider, F. R. N.
name: Taylor, W. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: TLUSTY non-LTE model atmosphere calculations have been used to determine atmospheric parameters and nitrogen (N) abundances for 34 single and 18 binary B-type supergiants (BSGs). The effects of flux contribution from an unseen secondary were considered for the binary sample. We present the first systematic study of the incidence of binarity for a sample of BSGs across the theoretical terminal age main sequence (TAMS). To account for the distribution of effective temperatures of the BSGs it may be necessary to extend the TAMS to lower temperatures. This is consistent with the derived distribution of mass discrepancies, projected rotational velocities (vsini) and N abundances, provided that stars cooler than this temperature are post RSG objects. For the BSGs in the Tarantula and previous FLAMES surveys, most have small vsini. About 10% have larger vsini (>100 km/s) but surprisingly these show little or no N enhancement. All the cooler BSGs have low vsini of <70km/s and high N abundance estimates, implying that either bi-stability braking or evolution on a blue loop may be important. A lack of cool binaries, possibly reflects the small sample size. Single star evolutionary models, which include rotation, can account for the N enhancement in both the single and binary samples. The detailed distribution of N abundances in the single and binary samples may be different, possibly reflecting differences in their evolutionary history. The first comparative study of single and binary BSGs has revealed that the main sequence may be significantly wider than previously assumed, extending to Teff=20000K. Some marginal differences in single and binary atmospheric parameters and abundances have been identified, possibly implying non-standard evolution for some of the sample. This sample as a whole has implications for several aspects of our understanding of the evolution of BSGs. Full abstract in paper
description: 21 pages, 15 figures, 11 tables
362. Patient reported outcome measure for Giant Cell Arteritis: Cross-sectional validation study
Creators: name: Joanna Robson1, 2
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background/Objectives: Giant cell arteritis (GCA) presents in people over the age of 50 with cranial, ocular, and large vessel vasculitis. This study ai to validate a disease-specific patient reported outcome measure (PROM) for patients with GCA, to capture the impact of GCA and its treatment on health-related quality of life. Methods: This cross-sectional study included UK patients with clinician-confirmed GCA; diagnosed within the last three years or flaring within the last year. Patients completed the 40 candidate PROM ite, the EQ5D-5L, CAT-PROM5 and self-report of disease activity. Rasch and factor analysis were used to determine internal validity and factor structure. Item reductions were based on clinical importance, Rasch model fit, and redundancy. Tests of validity included comparison of the GCA-PROM (i) in participants with ‘active disease’ versus patients ‘in remission’ (known groups validity) and (ii) with EQ5D-5L and CAT-PROM5 scores (convergent validity). Results: The survey included 428 patients, mean age (SD) of 74.2 (7.2), 285 (67%) female. 327 (76%) cranial GCA, 114 (26.6%) large vessel vasculitis and 142 (33.2%) ocular involvement. Positive diagnostic tests included 167 (39%) temporal artery biopsy, 177 (41.4%) temporal artery ultrasound, and 51 (11.9%) Positron Emission Tomography and Computed Tomography (PET-CT). One huned and eight participants (25%) received second-line immunosuppressants, and 34 (7.9%) anti-IL6 therapy. Active disease was reported in 197 (46%). After the initial analysis (40 ite), ten ite were deleted, and two response categories collapsed to ensure overall fit to the Rasch model. This resulted in a final PROM comprising a 30-item scale with a 4-response category structure. Factor analysis confirmed four factors (domains): Acute sympto (8 ite), Activities of daily living (7 ite), Psychological (7 ite) and Participation (8 ite), all of which individually fitted the Rasch model (X2 = 25.219, DF=24, p=0.394 including reliability [Person Separation Index, PSI=0.828]), (construct validity). Each domain correlated, at least moderately, with EQ5D-5L and CAT-PROM5 scores (Spearman’s Correlation Coefficients 0.44 to 0.78) (convergent validity). The new GCA-PRO discriminated between patients with active disease and remission (known groups validity) (Table 1). Conclusions: The 30-item GCA-PROM demonstrates internal and external validity in measuring health-related quality of life in people with GCA. Disclosures: None
Social Self-Efficacy and Psychosocial Impact of Ostomy in Young Adults between 18- 25 Years: A Descriptive Cross-Sectional Survey Study
Creators: name: Vaughn, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description:      Many gastrointestinal conditions that commonly occur in young adults may result in the creation of an ostomy, but little ostomy research focuses on this population. Young adults with ostomies may face unique challenges compared to other age groups, especially regarding their psychosocial wellbeing. The purpose of this study is to assess the effects of having an ostomy on the psychosocial status and social self-efficacy of young adults between the ages of 18 and 25.  The study followed a descriptive cross-sectional design. Adults who had an ostomy between the ages of 18 and 25 (N = 13) participated in this study and self-rated their responses on Negative Psychosocial Illness Impact and Self-Efficacy related to ostomy. The data were collected via online survey using the Patient-Reported Outcomes Measurement Information System tools of Negative Psychosocial Illness Impact and Self-Efficacy for Managing Chronic Conditions. The survey found that the ostomy had a marked negative psychosocial impact for a majority (84.6% of participants). Low self-efficacy in managing social interactions with an ostomy was reported by 53.8% of the participants. The results also highlight the need for increased psychosocial support for young adults with ostomies, specifically from their healthcare teams. Due to the small sample size, the results of the survey are not generalizable and no associations could be made. Further research is needed to explore whether significant relationships exist among psychosocial impact, social self-efficacy and demographic variables for young adults with ostomies.
Wie arm muss die Kirche, wie reich darf sie sein?
Creators: name: Winkler, Hans
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 1 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 1
Predigt, Schriftlesung und geistliche Begleitung
Creators: name: Schwienhorst-Schönberger, Ludger
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 1 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 1
Magnetic Fields and Galactic Star Formation Rates
Creators: name: Van Loo, Sven
name: Tan, Jonathan C.
name: Falle, Sam A. E. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The regulation of galactic-scale star formation rates (SFRs) is a basic problem for theories of galaxy formation and evolution: which processes are responsible for making observed star formation rates so inefficient compared to maximal rates of gas content divided by dynamical timescale? Here we study the effect of magnetic fields of different strengths on the evolution of giant molecular clouds (GMCs) within a kiloparsec patch of a disk galaxy and resolving scales down to $\simeq0.5\:{\rm{pc}}$. Including an empirically motivated prescription for star formation from dense gas ($n_{\rm{H}}>10^5\:{\rm{cm}^{-3}}$) at an efficiency of 2\% per local free-fall time, we derive the amount of suppression of star formation by magnetic fields compared to the nonmagnetized case. We find GMC fragmentation, dense clump formation and SFR can be significantly affected by the inclusion of magnetic fields, especially in our strongest investigated $B$-field case of $80\:{\rmμ}$G. However, our chosen kpc-scale region, extracted from a global galaxy simulation, happens to contain a starbursting cloud complex that is only modestly affected by these magnetic fields and likely requires internal star formation feedback to regulate its SFR.
description: 7 pages, 5 figures. Accepted by ApJ Letters
365. Vitamin D status in ANCA-associated vasculitis
Creators: name: Doubelt1, Irena
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background/ Objectives: Vitamin D may participate in the pathogenesis of some immune-mediated diseases, although this topic has been minimally examined in ANCA-associated vasculitis (AAV). The aim of this study was to measure the vitamin D status and its association with disease activity in a cohort of patients with AAV. Methods: Vitamin D levels were measured in stored serum samples of 125 randomly selected patients with granulomatosis with polyangiitis (n=50), eosinophilic granulomatosis with polyangiitis (n=50), or microscopic polyangiitis (n=25) enrolled in the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Studies. Sera samples were selected from visits at the time of enrolment, and a subsequent relapse visit for patients who had a relapse during follow-up. Levels of 25-hyoxyvitamin (25[OH]D) were measured using ELISA. Insufficiency was defined as a 25(OH)D level between 20-30 ng/mL (50-75 nmol/L), and deficiency as ˂20 ng/mL (<50 nmol/L). Results: Seventy (56%) of the study patients were female, with a mean age at diagnosis of AAV of 51.5+/-16 years; 84 (67.2%) were or had been positive for the presence of ANCA. Main disease manifestations included lung (80%), renal (45.6%) neurologic (42.4%), and/or ears/nose/throat (41.6%) involvement. At their enrollment visit, 79 (63.2%) patients were in remission, the remaining 46 (36.8%) having some disease activity. Mean vitamin D level at enrollment was 37.7+/-16.3 ng/ml; vitamin D deficiency and insufficiency was seen in 13 (10.4%) and 26 (20.8%) patients, respectively (Figure 1). Higher serum levels of vitamin D at enrollment were associated with female sex (p=0.027) and inactive disease (p=0.047) in univariate analysis, but not in multivariate analysis. In both univariate and multivariate analysis deficiency status at enrollment was associated only with active disease (p=0.015). Mean level of 25(OH)D in the 21 patients with a subsequent relapse visit did not differ between baseline and relapse visit (37.8+/-3.6 vs. 38.0+/-9.6 ng/ml, respectively; p=0.92), with deficit in 1 (4.8%) and insufficiency in 3 (14.3%) of the 21 patients at the time of relapse (p=0.28 for comparison to baseline distribution). Conclusions: Most patients in this cohort of AAV had sufficient 25(OH)D levels. Levels were higher in patients in remission at enrollment, but did not significantly change in patients who had a subsequent relapse. Whether optimization of vitamin D status alters disease manifestations or activity remains to be determined. Disclosures: The authors declare no disclosures.
Effects of obesity on the efficacy of PEGylated liposomal doxorubicin in patients with platinum-resistant or refractory ovarian cancer
Creators: name: Whitehead, Zachary
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: INTRODUCTION: Studies have shown that body habitus significantly influences nanoparticle (NP) pharmacokinetics (PK) and potentially pharmacodynamics (PD). NPs, such as pegylated liposomal doxorubicin (PLD), are primarily cleared by the mononuclear phagocyte system (MPS), which is part of the innate immune system. Obese body habitus (OBH) is associated with a higher incidence of ovarian cancer. In addition, OBH is associated with increased MPS function, which has been shown to reduce NP exposure. Thus, we evaluated the effects of body habitus on PLD response in patients with platinum-resistant and refractory ovarian cancer. METHODS: This study employed a retrospective chart review to collect data from patients within the UNC Health System who received PLD monotherapy for the treatment of platinum-resistant or refractory ovarian cancer. The patient cohorts were defined by body mass index (BMI) and consisted of non-obese (BMI <30 kg/m2 ) and obese patients (BMI ≥30.0 kg/m2 ). The primary clinical endpoint was progression-free survival (PFS). RESULTS: For PLD monotherapy, the mean ± SD PFS in patients that were non-obese (n=38) and obese (n=19) were 150.2 ± 85.5 days and 108.4 ± 65.4 days, respectively (p=0.05). When comparing PFS between the different cohorts, PFS was found to be 38.6% longer among nonobese individuals compared to those who are obese. According to RECIST, 42.1% of nonobese patients showed a response to therapy or stable disease at some point during treatment compared to 26.3% of obese patients. CONCLUSIONS: Obese patients that received PLD monotherapy had lower PFS compared to non-obese patients. This is consistent with our theory that obese patients have higher MPS function and lower exposures of PLD in their blood that results in reduced response. Thus, obese patients may require a higher dose to achieve the same PK exposure as non-obese patients. Ongoing studies are evaluating if the dose of PLD and other nanoparticles in overweight and obese patients may be optimized and individualized by using biomarkers of the MPS.
title: Future Scenarios as an Appropriate Way for Designers to Anticipate the Future
Creators: name: Akin, Izzettin Fazil
Publisher: name: University of Liverpool Repository
Year: 2022

description: Designers are the people who build the future through their activities. Imagining and affecting the future is a key responsibility of designers. There are many ways to anticipate the future such as trend forecasting, Delphi studies, science fiction stories and so on. Also, there are techniques which have their roots from the design discipline such as design fiction, or design probes. In this research, the focus is on future scenarios as a way to speculate about the future. This research aims to show the value of how scenario planning methodology will increase the credibility of designers while they develop their ideas and products for the future. Scenarios are a powerful tool for discussing situations and showing the results of our current decisions. Through interviews with three experts, case studies and a review of the methods for anticipating the future, the value of future scenarios for designers has been shown.
Die Kirche - "Gesandt, die Liebe Gottes allen Menschen und Völkern zu verkünden"
Creators: name: Predel, Gregor
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 1 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 1
Reentrant superconductivity in URhGe
Creators: name: Mineev, V. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: There is presented a phenomenological description of phase diagram of ferromagnet superconductor URhGe. In frame of the Landau phenomenological theory it was found that phase transition between anisotropic ferromagnetic and paramagnetic states under strong enough magnetic field perpendicular to direction of easy magnetization changes from the second to the first order type. It is shown that magnetic susceptibility corresponding to longitudinal magnetic fluctuations strongly increases in vicinity of the first order transition stimulating reentrance of superconducting state. The reentrant superconductivity observed near the first order transition line at temperatures about twice lower than the tricritical point temperature exists both in ferromagnet and paramagnet state. The critical temperature of transition to superconducting state falls down at intersection with line of ferromagnet-paramagnet phase transition.
description: 5 pages, no figures
357. Bronchitis in patients receiving prolonged rituximab for ANCA-associated vasculitis
Creators: name: Zonozi1, Reza
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background/ Objectives: Pulmonary complications from B cell depletion with rituximab remain with limited description in the literature. Our objective is to describe the frequency and risk factors for development of cough attributed to bronchitis in patients receiving prolonged rituximab. Methods: We conducted a single-center retrospective cohort study of 113 adult patients with AAV who had continuous B cell depletion with rituximab for greater than 24 months. The primary outcome measure was an episode of cough measured with an ordinal scale as follows: 0 = no cough; 1 = daily cough, non-productive; 2 = cough with sputum production once daily; 3 = cough with sputum production twice or more daily. Secondary outcome measures included serum immunoglobulin G (IgG) level, sputum culture results, and antibiotic use for bronchitis. Univariate logistic regression analysis was used to assess the odds ratio of developing cough with smoking status, nadir IgG level, length of time on continuous B cell depletion, and lung involvement of AAV as independent variables. Results: Of the 133 patients, the mean age was 57 years and 47% (n = 53) were female. The median (IQR) duration of continuous B cell depletion was 3.4 years (2.7 – 5.2). The ANCA serotype was PR3 in 62 patients (54.9%), and MPO in 51 patients (45.1%). Fifty-four patients (47.8%) had lung involvement as part of AAV. Five patients (4.5%) and 43 patients (38.4%) were current and former smokers, respectively, while the remainder never smoked. A y cough was observed in 4.2% of patients (n = 5). A daily cough with sputum production once daily was observed in 6.2% of patients (n = 7). A daily cough with sputum production twice or more daily was observed in 11.5% of patients (n = 13). A specimen for sputum culture was obtained in 25 patients, 12 (48%) of which were positive for a bacterial organism. The most common was Haemophilus influenzae (n = 2). Antibiotics for suspected bacterial bronchitis were used in 19.5% of patients (n = 22). The median nadir IgG level was 675 mg/dL (521 – 798). No patient required intravenous IgG supplementation. In a univariate logistic regression model, the smoking status, nadir IgG level, length of time on continuous B cell depletion, and lung involvement of AAV were not associated with an increased odds of developing a cough. Conclusions: Cough attributed to bronchitis was observed in approximately one-fifth of patients with AAV on prolonged B cell depletion with rituximab. Disclosures: None.
title: Research and Design for a Material Sample Information System Appropriate to Industrial Design Students
Creators: name: Akin, Izzettin Fazil
Publisher: name: University of Liverpool Repository
Year: 2022

description: The material of a product is one of the most important elements of product design that an industrial designer considers. It is also a major aspect of product innovation. Unfortunately, most of today’s material selection systems have been built on a technical basis and with an engineering perspective on product design. Current research shows that a physical environment allowing industrial designers to interact with material samples would greatly enhance designers’ material judgements and expertise and, therefore, the quality of subsequent product designs. Such an environment is argued to require different types of material samples and, in addition, to provide access to supplementary sample information that can support industrial designers’ decision-making. Different levels of materials information detail are required for different design phases. The information needed in the concept generation phase of a product is not the same as in the finalization stage. Furthermore, design students have different material information needs than design professionals. Through the thesis, existing material sample environments and sample tagging solutions, along with related literature, are explored and different types of information systems are analyzed to arrive at a set of specifications for a material sample information system appropriate to industrial design students, during the concept generation phase of a product. Utilizing a research through design approach, a solution for a material sample information system is proposed and justified against the developed design specifications.
Quasiparticle Dispersions and Lifetimes in the Normal State of the BCS-BEC Crossover
Creators: name: Reichl, Matthew D.
name: Mueller, Erich J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We compute the spectral density in the normal phase of an interacting homogenous Fermi gas using a T-matrix approximation. We fit the quasiparticle peaks of the spectral density to BCS-like dispersion relations, and extract estimates of a "pseudo-gap" energy scale and an effective Fermi-wavevector as a function of interaction strength. We find that the effective Fermi-wavevector of the quasiparticles vanishes when the inverse scattering length exceeds some positive threshold. We also find that near unitarity the quasiparticle lifetimes, estimated from the widths of the peaks in the spectral density, approach values on the order of the inverse Fermi-energy. These results are consistent with the "breakdown of Fermi liquid theory" observed in recent experiments.
description: 5 pages, 7 figures, revtex4; extended discussion of experiments in Sec. 4, references added
The Role of Tau, CHIP, and the Postsynaptic Density in the Pathogenesis of Alzheimer’s Disease
Creators: name: Singh, Suvleen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Alzheimer’s disease (AD), a neurological disorder that results in cognitive decline and memory deficits, has a yet unknown origin. However, aggregation of beta-amyloid plaques and neurofibrillary tangles (NFTs) in neurons represent two known hallmarks of the disease. The latter is made up of the Tau protein, which plays a significant role in maintaining the stability of the cytoskeleton. This protein undergoes a number of post-translational modifications (PTMs), but we are most interested in caspase-mediated cleavage, which confers neuronal toxicity. Preliminary work suggests that the ubiquitin ligase protein CHIP may also play a role in Tau cleavage. Additionally, pathological Tau has been shown to be localized to the postsynaptic density (PSD), causing further damage to the neuron. This study examined the interactions between cleaved Tau, CHIP, and the PSD and speculates on the mechanism of Tau cleavage. Through transfections of HEK 293 cells and a series of co-immunoprecipitation experiments followed by western blot analysis, we were able to visually identify potential interactions between these three cellular components. Our findings strongly suggest an interaction between CHIP, cleaved Tau, and the PSD, with CHIP possibly serving a role in Tau transport to the PSD. Further elucidation of these interactions will help to create a better understanding of the Tau cleavage mechanism and how it relates to the development and progression of AD. In concert with future research, this could lead to the development of drugs that specifically target this pathway to aid in the alleviation of symptoms associated with AD.
"Schwerter zu Pflugscharen" - Auf dem Weg zu einem gerechten Frieden
Creators: name: Sailer-Pfister, Sonja
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 1 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 1
361. A History of Autoimmune Disease is associated with fewer Relapses in patients with ANCA Vasculitis
Creators: name: Lionaki1, Sophia
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Objectives: To explore the frequency and impact of an autoimmune disease past-medical history (PMH) in the clinical picture and outcomes of patients with antineutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV). Patients and methods: This was a retrospective study of patients with biopsy-proven AAV, >16 years old, with detailed information about their PMH. Outcomes of interest included remission, treatment resistance, relapse, end-stage kidney disease (ESKD), and death. Results: 206 patients with biopsy-proven AAV and available information regarding their PMH were studied. 63(30.6%) of them had a history of autoimmune disease prior to AAV diagnosis. The mean age overall was 54.1 years. One huned and five patients (51%) were positive for PR3-ANCA, 101(49%) for MPO-ANCA. Granulomatosis with polyangiitis was diagnosed in 79(38.3%), microscopic polyangiitis in 97(47.1%) and renal-limited vasculitis in 30(14.6%) individuals. Remission rate was similar among patients with and without a PMH of autoimmune disease. Time-to-event analysis indicated that the relapse-free survival was significantly longer in patients with PMH of autoimmune disease (148.2 versus 61.9 months, p-value <0.001). After adjusting for covariates, autoimmune disease history was associated with significantly lower risk of relapse (HR: 0.33, 95% CI: 0.15-0.72), which remained significant in males, patients ≥60 years old and those with C/PR3-ANCA, kidney and lung involvement. Conclusions: Patients with a PMH of autoimmune disease, prior to AAV diagnosis, experienced significantly fewer relapses after achievement of remission, compared to patients without such a history, underlining the importance of individualization of maintenance immunosuppressive therapy, given the different etiopathogenetic settings the disease was developed. Disclosures: None
Der böse Zauber des Militärs
Creators: name: Gerigk, Horst-Jürgen
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 1 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 1
Superconductivity in intercalated group-IV honeycomb structures
Creators: name: Flores-Livas, José A.
name: Sanna, Antonio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present a theoretical investigation on electron-phonon superconductivity of honeycomb MX$_2$ layered structures. Where X is one element of the group-IV (C, Si or Ge) and M an alkali or an alkaline-earth metal. Among the studied composition we predict a $T_c$ of 7 K in RbGe$_2$, 9 K in RbSi$_2$ and 11 K in SrC$_2$. All these compounds feature a strongly anisotropic superconducting gap. Our results show that despite the different doping and structural properties, the three families of materials fall into a similar description of its superconducting behavior. This allows us to estimate an upper critical temperature of about 20 K for the class of intercalated group-IV structures, including intercalated graphite and doped graphene.
description: Phys. Rev. B
Abschied vom "Ewigen Frieden"?
Creators: name: Zaborowski, Holger
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 43 Nr. 1 (2014): Internationale katholische Zeitschrift Communio, Band 43, Heft 1
Report for workshop/innovation activities 1
Creators: name: KOMPETENZZENTRUM HOLZ GMBH
Publisher: name: Zenodo
Year: 2025

description: In order to develop the innovation activities in a targeted manner, firstly a two-dayworkshop with a comprehensive project program was set up. This workshop was held as partof work package 4 ‘Workshop/ Innovation Activities’. The event was held on 12th and 13thSeptember 2024 in Linz by the work package leader Wood K plus. The partners and membersof the ‘Bio-Acouis’ project as well as privately interests parties and state funding bodies wereinvited. The purpose of this workshop was to present and discuss the results of the scientificwork in a public auditorium. The speakers included partners of ‘Bio-Acouis’ as well asscientific staff from Wood K plus. In addition to the presentations, group discussions were alsoheld on three flipcharts on topics relevant to ‘Bio-Acouis’. The workshop concluded with a tourof the technical centre and a discussion on the future of bio-based materials. At the end ofsessions 1 and 2, an initial statement for the continuation of the innovation activities wasdiscussed.
Germline DPYD Variant Effect on Fluorouracil Toxicity
Creators: name: Mills, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The fluoropyrimidines, 5-fluorouracil (5-FU) and capecitabine, are widely used for solid tumor treatment. They can cause early-onset, severe toxicities such as neutropenia, mucositis, colitis, emesis, and hand-foot syndrome. 5-FU and capecitabine are metabolized by the DPD enzyme, coded for by the DPYD gene. Current pharmacogenetic guidelines from the Clinical Pharmacogenetics Implementation Consortium (CPIC) suggest testing for DPYD variants before initiation of these antineoplastics. The clinical utility of DPYD testing is limited because only a few variants are known to significantly influence clinical outcomes. This analysis includes novel DPYD mutations that may explain interpatient variability in fluoropyrimidine toxicities. The variants analyzed were discovered via an analysis of SNP effect on liver gene expression and have never been studied in relation to 5-FU toxicity. Novel snp1 decreases DPYD expression and is expected to increase 5-FU toxicity. Novel snp2 increases DPYD expression and is expected to decrease 5-FU toxicity.
This retrospective cohort analysis included patients from the CALGB 80405 trial if they were of genetically determined European-descent and received FOLFOX for colorectal cancer. Patients with severe 5-FU-related early-onset toxicity were compared to a control group of patients with no early-onset 5-FU-related toxicity (of any grade). Chi-squared tests were utilized for statistical analysis. Severe, early-onset toxicity was defined as combined fluoropyrimidine-related toxicity (grade ≥3 neutropenia, mucositis, diarrhea, nausea or vomiting, and hand/foot disease) occurring in cycles 1 or 2 of treatment. The DPYD variants studied were two novel variants (snp1, snp2). Two DPYD variants from current guidelines (*2A, HapB3) are included as positive controls. There are three variants with strong evidence in the current guidelines, but these two were selected for controls because they were available in the dataset.
Patients homozygous for snp2 had a significantly lower percentage of severe, early-onset neutropenia and severe, early-onset combined toxicities compared to wild-type and heterozygous patients. Patients with *2A and hapB3 heterozygous mutations had a greater percentage of severe, early-onset neutropenia and overall toxicities, compared to wild-type patients. This was statistically significant for *2A. Patients homozygous for snp1 did not have a significantly higher percentage of toxicity, compared to wild-type and heterozygous patients.
This analysis supports the inclusion of snp2 in guidelines predicting fluoropyrimidine toxicity based on DPYD. Adding new variants to the guidelines could improve patient outcomes by supporting initial fluoropyrimidine dosing based on genotype. This has the potential to improve the toxicity profile of heavily utilized chemotherapies.
Stabilizing the Higgs potential with a Z$'$
Creators: name: Di Chiara, Stefano
name: Keus, Venus
name: Lebedev, Oleg
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Current data point toward metastability of the electroweak vacuum within the Standard Model. We study the possibility of stabilizing the Higgs potential in U(1) extensions thereof. A generic Z$'$ boson improves stability of the scalar potential in two ways: it increases the Higgs self--coupling, due to a positive contribution to the beta--function of the latter, and it decreases the top quark Yukawa coupling, which again has a stabilizing effect. We determine the range of U(1) charges which leads to a stable electroweak vacuum. In certain classes of models, such stabilization is possible even if the Z$'$ does not couple to the Higgs and is due entirely to the reduction of the top Yukawa coupling. We also study the effect of the kinetic mixing between the extra U(1) and hypercharge gauge fields.
description: 14 pages, 7 figures; a typo in Delta V fixed, references added