cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluating the Online Mood Assessment Post Stroke (O-MAPS) training: a phase II randomized-controlled trial
Creators: name: El-Helou, Rebecca
name: Ryan, Brooke
name: Rogers, Jeffrey M.
name: Marsden, Dianne L.
name: Winkler, Ann
name: Baillie, Andrew
name: Elhindi, James
name: Gallagher, Liz
name: Kneebone, Ian
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Anxiety and depressive disorders as well as suicidal ideas are common post stroke and early identification via routine screening is imperative for stroke survivors to access formal assessment and treatment. Currently there is a dearth of training programs available and no online mood screening training programs have been evaluated to date. The current study aims to evaluate the Online Mood Assessment Post Stroke Training Program (OMAPS) developed in partnership with the Stroke Foundation in Australia via a phase II wait listed Randomized Control Trial. Recruitment occurred online via webinars and social media pages for stroke clinicians and enrolled participants were randomized, using REDCAP randomization software, into the immediate intervention group or wait list control (where participants waited for one week to complete the training). Participants completed a Mood Screening Self-Efficacy Questionnaire (MSEQ) and a mood screening knowledge quiz, pre and post training. Participants were followed up one month following via e-mail to determine whether they implemented the training. The results indicated that participants screening knowledge quiz scores improved (M = 1.01, t (59) = 6.81, p=<0.0001, d = 1.05) and self-reported self-efficacy increased for both groups after completing the training (t = 8.294, p < 0.001). Many participants reported a change of practice following completing the training and others reported remaining barriers to implementation. The results of this study are promising and indicate the preliminary efficacy of the OMAPS training program in boosting stroke clinicians’ self-efficacy in mood screening. Further studies should evaluate and explore other changes in clinical practices as a result of the training.
Batrachoididae Jordan 1896
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Batrachoidiformes
Batrachoididae

description: Family Batrachoididae Jordan 1896 (Fig. 3G). Toadfishes; Peces Sapo, Picadores, Peces Fraile, Brujas
Description: Body relatively elongate and robust, with a relatively large, wide and flattened head; up to 57 cm in length; head with barbels and/or fleshy flaps; mouth wide; eyes directed upward and positioned on the top of the head; spines usually present on operculum and suboperculum; scales usually absent; 1-4 lateral lines on head and body; pelvic fins located under the operculum, before pectoral fins, with one spine and 2–3 rays (Robertson & Allen 2015, Nelson et al. 2016). Distribution: Marine (primarily coastal benthic), rarely entering brackish water and a few species confined to freshwater; Atlantic, Indian and Pacific oceans (Nelson et al. 2016). One genus and two species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 30, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Pemberton Township master plan summary
Creators: name: Associates, Alvin E. Gershen
Publisher: name: No Publisher Supplied
Year: 1972

description: Summary of the findings of the master plan background studies and proposals for future land use, traffic circulation and community facilities. Combining the findings of the studies of Physical Characteristics, Land Use, Population and Housing and Transportation, this report suggests both future planning proposals and a method for their implementation. Within the proposals for future land use are contained seven residential districts, three commercial districts and two types of industrial districts. The circulation plan is concentrated on expanding the existing network of collector roads within the township to form a more complete network of traffic circulation. The facilities plan represents a comprehensive analysis of existing community facilities and suggests additional facilities and open space proposals.
MOESM1 of Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections
Creators: name: Thomas, Guillemette
name: Hraiech, Sami
name: Cassir, Nadim
name: Lehingue, Samuel
name: Rambaud, Romain
name: Wiramus, Sandrine
name: Guervilly, Christophe
name: Klasen, Fanny
name: MĂŠlanie Adda
name: StĂŠphanie Dizier
name: Roch, Antoine
name: Papazian, Laurent
name: Forel, Jean-Marie
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Table S1. Microorganisms cultured in different samples of 103 Extracorporeal Membrane Oxygenation (at the time of ECMO removal).
Identifying synthetic lethalities in tumors harboring mutations in IDH1 or IDH2
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Mutations in metabolic enzymes frequently contribute to tumorigenesis. Whether the mechanism of action lies in loss of function or gain of function modifications to proteins, these genetic lesions cause metabolic defects to arise in tumors. Mutations in isocitrate dehydrogenases (IDHs) 1 and 2 occur at high frequencies in low grade gliomas, acute myeloid leukemia, and occasionally in various other tumors. These NADP+-dependent enzymes produce the oncometabolite (R)-2-hydroxyglutarate and exhibit minimal "normal" activity. Here we will apply isotope tracing and metabolic flux analysis to identify the metabolic behavior of an isogenic panel of cells harboring heterozygous mutations in IDH1 or IDH2. We have preliminary evidence that such mutations compromise metabolic regulation in response to drugs or other stresses. These experiments will be conducted by culturing cells in the presence of [13C] and [2H] tracers, extracting metabolites, and quantifying isotope enrichment in biomass and free metabolite pools via mass spectrometry. Labeling data is incorporated into systems-level metabolic network models of central metabolism to estimate fluxes in each cell type and condition. We aim to accomplish the following objectives: 1. Perform 13C metabolic flux analysis in an isogenic panel of IDH mutant cell lines to identify metabolic defects arising associated with these oncogenic mutations 2. Trace cofactor metabolism in our cell panel to investigate specific dependencies on NADPH-generating pathways arising from IDH mutations. 3. Evaluate the sensitivity of parental, IDH1, and IDH2 mutant cells to specific metabolic inhibitors targeting pathways identified in Aims 1 and 2.
Qianxie solegladi Tang 2022
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Pseudochactidae
Qianxie
Qianxie solegladi

description: (1) Qianxie solegladi Tang, 2022
TYPE LOCALITY AND TYPE DEPOSITORY. China, Yunnan Province, Kunming City, Luquan County, Wumeng Township, Zhongping Village; VT.
CHINESE EQUIVALENT. ‡氏ffx.
DISTRIBUTION (●). Sichuan: Liangshan Prefecture, and Panzhihua and Yibin cities; Yunnan: Chuxiong and Kunming cities.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Batrachoides surinamensis
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Batrachoidiformes
Batrachoididae
Batrachoides
Batrachoides surinamensis

description: Batrachoides surinamensis (Bloch & Schneider 1801) (Fig. 7H). Pacuma Toadfish; Sapo Guayanés
Vouchers: Not available. Distribution: Western Atlantic Ocean; from Honduras to northern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Pr and BF (Atlantic); 0–4 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Fowler (1923: 32; listed, including information on distribution), Collette & Russo (1981: 203; information on distribution), van den Berghe (2015: 47; listed, including an illustration and information on distribution and ecology) and Robertson & Van Tassell (2019: 3152; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 30, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Scorpiops asthenurus Pocock 1900
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops asthenurus

description: (1) Scorpiops asthenurus Pocock, 1900
TYPE LOCALITY AND TYPE DEPOSITORY. India, West Bengal State, Kalimpong, near Darjeeling; NHMUK.
CHINESE EQUIVALENT. 弱尾ẍx.
DISTRIBUTION (○). Xizang: Nyingchi City (Mêdog and Zayü counties) and Shannan City (Tsona City); = “ Arunachal Pradesh ”.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Tetramorium bicarinatum
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium bicarinatum

description: The bicarinatum -group
Antennae with 12 segments, sting appendage triangular, dentiform or pennant-shaped. Anterior clypeal margin with a median notch or impression. Median portion of clypeus with three principal longitudinal carinae, often without other sculpture but sometimes with another much weaker pair of carinae. Mandibles variously sculptured, smooth to striate. Frontal carinae strongly developed, reaching back almost or quite to the occipital margin. Propodeal spines always strongly developed, straight to somewhat upcurved along their length. First gastral tergite commonly costulate basally. Basic sculpture throughout the group a strong rugoreticulum. Pilosity usually abundant, elongate and fine; short truncated hairs absent.
This group contains a number of the larger and more conspicuous members of the genus. The Oriental / Indo-Australian region has a total of 13 species and the Ethiopian region about 15.
One species of the group, bicarinatum, is a highly successful tramp-species and has been recorded from all over the world except for the Ethiopian region. Two other members of the group have some tramping ability, insolens and pacificum. The former closely resembles bicarinatum and has been found to date in Britain, Germany and the U. S. A., but always as an introduction or living in zoological or botanical gardens. The latter occurs sporadically in California where it has been recorded by M. R. Smith (1943) and Creighton (1950). The species has an enormous range in the Indo-Australian and Oriental regions and seems to be present on most of the Pacific island-systems, so it is hardly surprising that it should occur occasionally on the west coast of the United States.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 164
Early tumor detection by active-feedback magnetic resonance molecular imaging
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Detection of cancer at an early, localized, and curable stage can substantially improve patient prognosis. While magnetic resonance (MR) imaging provides better contrast than other imaging modalities in the later stages of cancer, MRI is not currently able to pick up on the subtle physiological changes in early-stage tumors. In developing MRI into a potent tool for detecting early tumors and cancerous changes in tissues, a general contrast and sensitivity amplification scheme for overcoming fundamental limitations in tumor contrast and detection sensitivity is needed. For this purpose, this proposal suggests a joint approach: (i) labeling early tumors by targeting the associated biomarkers with novel contrast agents in MR molecular imaging (e.g., magnetic nanoparticles conjugated with antibodies), and then (ii) sensitively imaging magnetic nanoparticles by our recently developed active-feedback magnetic resonance. The specific objectives are: (i) Instrumentation -- build an electronic active-feedback device, in order to extend the applicability of the proposed method for sensitive imaging of magnetic nanoparticles to low-field MR spectrometers and imagers with programmable and controllable feedback phase, gain, and duration; (ii) Experiments -- image in vivo mouse pancreatic cancer mouse models, in order to evaluate the performance of the proposed method over existing popular MR imaging modalities and to demonstrate its potential biomedical applicability. As preliminary results, in vivo images of human pancreatic cancers from both subcutaneous and orthotopic xenograft mouse models were carried out, where the pancreatic cancers were targeted by the CA19-9 bio-conjugated magnetic nanoparticles and imaged by the Active Feedback MR method. Both subcutaneous and orthotopic pancreatic cancer mouse models show that, while T2-weighted image cannot clearly locate the magnetic nanoparticles, the active-feedback images successfully highlight the magnetic nanoparticles distribution with a close correlation with iron-stained histopathology.
Mecodium
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Mecodium

description: Subgenus Mecodium
Subgenus Mecodium potentially groups five species in the area including eastern and southern Africa and the western Indian Ocean. These species are morphologically close and are thus often confused (Fig. 5): paleotropical populations of supposedly H. polyanthos (Sw.) Sw., East and South-African and Indian Ocean H. capense Schrad., East and South-African H. kuhnii C.Chr., the western Indian Ocean H. fumarioides Bory ex Willd. and H. inaequale (Poir.) Desv. In the fern flora of South Africa, Sim (1915) considered H. capense as a synonym of H. fumarioides, and H. inaequale is cited in the area but not H. kuhnii contrary to the other more recent local floras (e.g., Burrows 1990). Roux (2009) restricted H. fumarioides (the type is a mixed collect from Mauritius and La Réunion: J.B.G.M. Bory de St.­ Vincent 119, holotype BW20229010, isotype P00547028) and H. inaequale to the Indian Ocean and Tanzania, H. capense being treated as a distinct species with a wider distribution including the Indian Ocean, eastern Africa and South-Africa.
Our investigations allowed us to recognize and propose here only three species for subg. Mecodium in the archipelago as we will discuss here-after. These species are H. capense, H. inaequale and H. kuhnii.
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 24, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Impact of inhibitors of the human spliceosome on cancer cell growth and gene expression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The larger goal of our work is understand the role of spliceosome function in the growth and gene expression profiles of cancer cells. The spliceosome is a large and dynamic RNA/protein complex that removes intron sequences from gene transcripts by a process known as splicing, which is an essential and highly regulated step in human gene expression. Mutations that affect the spliceosome and splicing are linked to a quickly growing number of genetic diseases, including many cancers. To dissect the complicated molecular mechanisms of splicing, there is a pressing need for small molecules that inhibit spliceosomes at different stages of the splicing process and can be used to probe the functions of the many proteins involved in splicing. My lab recently piloted a high-throughput screen (HTS) for splicing inhibitors. We identified three compounds that block splicing in vitro and affect different stages of spliceosome assembly, and are continuing the search for more compounds that target any of the nearly 100 spliceosome components. We are also working with Dr. Arun Ghosh to determine the structure-activity relationships of Pladienolide B (PB), a complex natural product that targets a component of the spliceosome and strongly inhibits splicing in vitro. In this proposal we will determine how in vitro spliceosome inhibitors affect growth and gene expression in human cancer cells. Preliminary data show that the inhibitors identified by HTS, as well as PB derivatives, alter HeLa cell growth. The growth defect may be due to general splicing inhibition, to inhibition of splicing of a subset of genes, or to off-target effects of the compounds. Differentiating between these possibilities is important for linking our biochemical/structural studies of the spliceosome to its cellular role in gene expression. It also may identify splicing programs that are important for cancer cell proliferation and serve as new targets for chemotherapeutic drugs. Specifically, we will use a cytological profiling assay to characterize the phenotypic effects of treating different cancer cell lines with spliceosome inhibitors. Correlation of in vitro splicing inhibition with changes in cell growth an morphology will indicate potential effects of altering splicing pathways in cells. We will address that possibility by using RT-qPCR to measure splicing levels of a set of test genes in HeLa cells exposed the compounds relative to a DMSO control, and compare the results with the effects siRNA knockdown of spliceoso
Additional file 2: of Globular domain structure and function of restriction-like-endonuclease LINEs: similarities to eukaryotic splicing factor Prp8
Creators: name: M. Mahbub
name: Saiful Chowdhury
name: Christensen, Shawn
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Developmental Biology
subject: 60506 Virology

description: R2Bm sequence and domain boundaries. (DOCX 28Â kb)
Novel antibody paratope design for highly selective inhibition of tumorigenic matrix metalloproteinases
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Proteolytic processing is involved in nearly every stage of cancer growth and progression. This makes cancer related proteases (MMP, ADAM, ADAMTS, MT-SP families) important regulatory enzymes for study and attractive targets for cancer therapy. Previous failure of broad-spectrum small molecule inhibitors in clinical trials and recent insights on the paradoxical roles of proteases in tumor progression emphasize that selectivity is the key for any protease-inhibition therapy. Due to extensive homology between catalytic domains of MMPs, it presents a great challenge to distinguish them by developing small compound inhibitors. With a large contact surface area and exquisite specificity, antibody-based inhibitors are therefore emerging as very promising therapeutic agents able to distinctly block cancer-promoting proteases rather than cancer-suppressing proteases. Unfortunately, to date, at least two obstacles make the routine discovery of protease-inhibiting antibodies considerably difficult: (1) low antigenicity of the proteolytic active sites, and (2) lack of a function-based selection method. Our long-term goal is to develop therapeutic mAbs targeting tumorigenic metalloproteases. The objective of this proposed CRCC research is to overcome the technical hurdles and establish general methodologies that facilitate the identification of inhibitory antibodies. The central hypothesis is that custom-designed synthetic antibody libraries can provide desired paratope features suitable for inhibitory functions. Building on my expertise in antibody selection, library construction and characterization, and our recent development of function-based inhibitory antibody selection method, we will, Step 1: Construct synthetic human antibody libraries enriched with protease-inhibiting paratopes; and Step 2: Fast identify protease inhibitory antibodies through FRET-based high-throughput selection methods, which were developed recently in my lab. The approaches are innovative, because it will construct synthetic human antibody libraries with novel inhibition-prone paratope features, and utilize ground breaking function-based rather than binding-based HTS methods. The proposed research is significant because it will facilitate the generation of specific protease-inhibiting human antibodies can be valuable reagents for diagnosis, prognosis, and therapy of cancer. In summary, this CRCC seed grant will provide initial and critical supports for the development of antibody-based MMP inhibitors. Established collaborations and coll
MicroRNAs - Tiny players with a major role in cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: MicroRNAs (miRs) exemplify the emerging view that non-coding RNAs (ncRNAs) may challenge proteins in regulatory importance. More than 50% of the human transcriptome is predicted to be under miR regulation, positioning this post-transcriptional control pathway within every major gene cascade. Given this pivotal role, it is not surprising that disruption of miR function contributes to many human diseases including cancer. This study interrogates mechanisms by which a single miR regulate the complex cellular states of tumorigenesis. We are utilizing miR lenti-viral library screens to identify miRs with novel functions in cancer. One screen has led to the identification of miR-367, which is normally only expressed in embryonic stem cells, but when expressed in differentiated cells such as pre-B-cells has oncogenic properties. We have preliminary data indicating, that tumor suppressor Pten and the apoptotic protein BIM are direct targets of miR-367. In addition, we find that STAT3 is strongly upregulated and modified in leukemia cells from sick mice, with an ALL-like pheotype. Analysis of human ALL patients specimens showns that a minority does express miR-367 at low levels. We propose to characterize which molecular pathways are involved in miR-367 induced tumorigenesis and to interrogate if restoring Pten and Bim levels, or attenuation of STAT3 levels prevents tumorigenesis. We believe that our study of the signaling pathways as well as the regulation of this onco-genic miR in cancer cells, will shed light on ways to counteract the dysregulation of miR-367 and thereby attenuate tumorigenesis.
Scorpiops atomatus Qi, Zhu & Lourenco 2005
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops atomatus

description: (2) Scorpiops atomatus Qi, Zhu & Lourenço, 2005
TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Nyingchi City, Nang County; MHBU (lost).
CHINESE EQUIVALENT. DZṄẍx.
DISTRIBUTION (●). Xizang: Nyingchi (Nang (Tonga Town) and Zayü (Xiazayü Town) counties) and Shannan (Gyaca County) cities.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 17, DOI: 10.5281/zenodo.14660932
Targeting sarcoma cancer stem cells with natural killer cell immunotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed intervention is a novel therapeutic regimen combining a tyrosine kinase inhibitor (sorafenib) which has shown activity in the clinical treatment of patients with soft tissue sarcoma (STS) with a cell-based immunotherapy using activated natural killer (NK) cells. Preliminary data from our laboratory demonstrate that sorafenib enriches for sarcoma cancer stem cells (CSCs), and CSCs are increasingly viewed as a mechanism of resistance to standard anti-proliferative cancer treatments. The senior mentor for this proposal has previously demonstrated that activated NK cells can attack human breast cancer and glioblastoma cells in vitro and in vivo, and his laboratory is well-established in the field of NK biology. Therefore, the central hypothesis of this proposal is that combining anti-proliferative sorafenib therapy that enriches for sarcoma CSCs with NK cell immunotherapy specifically targeting the remaining sarcoma CSCs will result in a greater and more durable therapeutic effect against STS, a disease with few effective treatment options for patients with advanced disease. If successful, this novel combination of targeted therapies may translate into improved therapy for many cancers. This hypothesis will be tested through the following specific aims: Aim 1: To demonstrate that sorafenib and NK immunotherapy are an effective combination therapy targeting non-CSCs and CSCs in a rodent xenograft model of human STS. Aim 2: To demonstrate that sorafenib and NK immunotherapy are an effective combination therapy targeting non-CSCs and CSCs in a canine clinical trial of spontaneous STS. Effects on oncologic outcome, CSC populations, and potential toxicities will be determined. Experimental techniques will include flow cytometry and immunohistochemistry to demonstrate targeting of CSC and non-CSC populations with treatment, bioluminescent imaging and survival studies to demonstrate therapeutic efficacy in rodents, and survival studies in canines. Human allogeneic NK cells will be used in xenograft studies. Autologous canine NK cells will be isolated and expanded from patients for treatment, and toxicity will be monitored by a Veterinary Oncologist.
Scorpiops deshpandei Tang, Ouyang, Liu & Stahlavsky 2024
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops deshpandei

description: (4) Scorpiops deshpandei Tang, Ouyang, Liu & Šťáhlavský, 2024
TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Nyingchi City, Mêdog County, Drepung Township; VT.
CHINESE EQUIVALENT. 德氏ẍx.
DISTRIBUTION (●). Xizang: Nyingchi City (Mêdog County: Drepung Township).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 17, DOI: 10.5281/zenodo.14660932
Batrachoides waltersi Collette & Russo 1981
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Batrachoidiformes
Batrachoididae
Batrachoides
Batrachoides waltersi

description: Batrachoides waltersi Collette & Russo 1981. Hairy Toadfish, Multipored Toadfish, Walter’s Toadfish; Sapo de Walter, Sapo Peludo
Vouchers: (other collections) TCWC 44406 (1; misslabeled as Batrachoides gilberti Meek & Hildebrand 1928).
Distribution: Eastern Pacific Ocean; from southern Mexico to northern Costa Rica; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Ni (Pacific); 0–7 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Collette & Russo (1981: 208; original description), Greenfield et al. (2008: 676; information on distribution) and Robertson & Allen (2015: 738; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 30, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Computation-guided discovery of p53 reactivation compounds
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: p53 is a tumor suppressor protein that prevents cancer by acting as a crucial cellular sentry that normally induces cell death in tumors. It is found in an inactive mutant form in approximately 50% of human cancers, including those that have been notoriously difficult to treat, such as cancers of the lung, colon, breast and ovaries. An attractive potential approach to cancer therapy is "reactivation" of inactive p53 mutants in cancer cells to shrink or kill the tumor. Using molecular dynamics simulations and computational solvent mapping experiments, we have discovered a novel p53 drug-binding site, surrounding Cys-124, that presents itself in an open, drug-accommodating conformation approximately 5% of the time in solution. Intriguingly, this new pocket is closed in the p53 x-ray crystal structures. Our work enabled the identification of the previously unknown, now newly discovered, biologically active binding site of the p53 reactivation drug PRIMA-1, which is currently in Phase I/II clinical trials in Sweden. We have developed an innovative computational platform including ensemble-based virtual screening to identify p53 reactivation molecules, and, as proof of principle, have identified three potential small molecule hits. I seek to transform cancer therapy through the development of small molecule compounds that will reactivate p53, and thus kill human tumor cells through two specific aims: Specific Aim 1: Characterize novel p53 binding sites in the 5 most prevalent p53 mutants in human cancers, using hybrid modeling methods that bridge low- and high-resolution structural data. We will expand our initial models to include the genomic response elements and integrate our structures into newly available low-resolution cryo-electron microscopy structural models of p53; these higher-fidelity models will be simulated with all-atom molecular dynamics. Specific Aim 2: Carry out large-scale ensemble-based virtual screening experiments of the 5 most prevalent p53 cancer mutant ensembles. We will carry out computational solvent mapping and ensemble-based virtual screening experiments on the structures obtained in Aim 1 to predict potential new hits for chemotherapy; initial screening libraries will include compounds from the NCI Molecular Therapeutics program, a marine natural products library from Scripps Institute of Oceanography, and ChemBridge. Top hits will be tested, as a first pass, in differential scanning fluorimetry assays and later, in human cell lines, by our expert collaborator
Latin rhotacism: a case study in the life cycle of phonological processes
Creators: name: Roberts, Philip J.
Publisher: name: No Publisher Supplied
Year: 2012

description: Rhotacism in Latin is a well-known phonological generalisation which, in its paradigm cases, can be stated as a regular sound change of [s] to [r] between vowels. This change/rule is posited on the basis both of comparative evidence, e.g. *swesor > Latin soror 'sister', and of paradigms in which final s alternates with medial intervocalic r, e.g. flos, floris 'flower'. It is possible, however, to cite a number of exceptions to the basic rule, which, if one attempts to account for all of them in a synchronic grammar, amount to outright paradoxes. This paper presents a diachronic model of the progress of rhotacism through the expected life-cycle of a phonological process, within the formalism of Stratal Optimality Theory, and demonstrates that this model can account for the exceptions to rhotacism as epiphenomena of the expected progress of the constraint ranking giving rise to it from phrase- to word-level, and from word- to stem-level. Finally, I argue that rhotacism became a systematic property of the lexicon, at which point it was subject to analogical extension, giving the paradigm levelling observed in e.g. honor, honoris 'honour' (formerly honos, honoris).
Additional file 3: of Globular domain structure and function of restriction-like-endonuclease LINEs: similarities to eukaryotic splicing factor Prp8
Creators: name: M. Mahbub
name: Saiful Chowdhury
name: Christensen, Shawn
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Glu C mapping data (amino terminal identification). (PDF 287Â kb)
Constraint Interaction and Brazilian Portuguese Glide Distribution
Creators: name: Giangola, James P.
Publisher: name: GLSA (Graduate Linguistic Student Association), Dept. of Linguistics, University of Massachusetts
Year: 1997

description: Glide distribution is a traditional problem for syllable, prosodic, metrical, and feature geometry theory. Brazilian Portuguese [BP] presents a particularly complex set of facts in these areas. The apparent unpredictability of glides may suggest that [y] and [w] must be phonemes (e.g. Barbosa 1965, Leite 19&4, Mateus 19&5). A phonemic analysis is based on the surface co-occurrence of [iw], [yu], and [i.u], as well as [uy], [wi], and [u.i]. However, BP glides are indeed predictable once one considers certain prosodic, metrical, and morphological tendencies to be found across languages. Optimality Theory (Prince & Smolensky 1993) maintains that the grammar is constructed of a set of ranked and violable constraints, rather than derivational or generative 'rules'. Since BP glide distribution can be explained solely in terms of general, cross-linguistically motivated constraints, an OT approach is relatively cost-free. In contrast, a traditional rule-based analysis must stipulate desyllabification rules which explicitly target high and mid vowels at various derivational levels.In this paper, I show that the sequence VG (vowel plus offglide) is distributionally less restricted than GV (onglide plus vowel) or V.V (vowels in hiatus). The more restricted forms, GV and V.V, obtain in prosodic, metrical, and morphological environments in which VG is disallowed. In an OT framework, the analysis takes on the following form: When input /VV/ corresponds to output VG, there are no constraint violations, while outputs GV and V.V violate more highly ranked Parse-mora and Onset, respectively. However, GV and V.V are optimal in those environments in which VG violates certain constraints ranked more highly than Parse-mora and Onset.
RNA nanomachines for cancer gene therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Many diseases, including cancer, are caused by inherited or acquired genetic abnormalities. Therefore, gene therapy has been considered as one of the most promising strategies for treating such diseases. One of the major challenges in gene therapy is specificity. The challenge is to therapeutically treat diseased cells and tissues (through gene therapy) while leaving the healthy cells and tissues intact. This is a significant challenge because: 1) diseased and normal cells are often co-located, and 2) genetic differences of the diseased and normal cells are very subtle (e.g. mutation(s) in one or few genes out of >30,000 genes). Consequently, it is extremely important to develop new fundamental gene therapy strategies that can sensitively distinguish diseased cells from normal cells and initiate treatment at molecular and cellular levels. The proposed research is based on the new “RNA nanomachine” architecture we recently developed. Conceptually, the nanomachine contains a sensor (made of RNA) that detects trigger molecules in living cells, and an effector that induces RNAi against a specific gene. The RNAi effector is inactive in the absence of the trigger molecules, but is released and activated when the sensor detects the trigger. Specifically, we plan to design and evaluate RNA nanomachines that can sense a cancer marker (NF-kappaB) and induce RNAi to demonstrate selective killing of liver cancer cells in vitro.
title: Formal analysis of communication protocols for wireless sensor systems
Creators: name: Valkov, Ivaylo
Publisher: name: University of Glasgow
Year: 2024

description: Sensor technology is an increasingly popular area of research due to the prevalent use of sensor devices. With the need for accurate, detailed data sensors are increasingly often used together in sensor networks. As the size of these sensor networks grows, so does the importance of efficient methods for their analysis for the prevention of system errors and discovery of design flaws. The increasing number of sensor devices leads to an exponential increase is the state space of the associated model. As such models of realistic systems are decreasingly often small enough for their verification to be feasible. Symmetry reduction techniques developed over the last 30 years, have been shown to be effective in reducing the state space explosion problem, particularly in the case of heterogeneous sensor systems, which contain many identical sensor devices.

In this thesis we present our approach to verifying Ctrl-MAC, a novel wireless network protocol that supports bidirectional communication of multiple simultaneous physical properties. We explore the extent to which symmetry reduction can aid the model checking process for a sensor network communication protocol. We present our results, and suggest statistical approaches based on our observations of the protocol.

We investigate the use of automated tools for the application of symmetry reduction, in particular GRIP, which is well suited for symmetry reduction of wireless sensor network systems. Models of communication protocols often require the use of synchronisation to model the interaction between devices. We present GRIP 3.0, a new version of the tool, which provides support for the use of synchronised transition statements. We provide results from practical work, coupled together with a discussion of drawbacks and future improvements.
Markedness Relations and Implicational Universals in the Typology of Onset Obstruent Clusters
Creators: name: Morelli, Frida
Publisher: name: GLSA (Graduate Linguistic Student Association), Dept. of Linguistics, University of Massachusetts
Year: 1998

description: Complex onsets consisting of two obstruents violate the Sonority Sequencing Principle, nevertheless a significant number of languages allows them as part of their inventories. I show that a cross-linguistic study reveals that the occurrence of the four possible obstruent clusters (i.e. FS, SF, FF and SS - F(fricative) and S(stop)) strictly obeys certain implicational universals. It is observed that the presence of FF implies the presence of FS, and that the presence of SS implies SF which in turn implies FS. Based on these implications, there are only six ways in which inventories of obstruent clusters can be constructed, and consequently only six possible grammars. Assuming implications as a means to determine markedness, the following markedness relations are established among the obstruent clusters. FF clusters are therefore shown to be more marked than SF clusters and SS clusters more marked than SF which in turn aremore marked than FS.I argue that an inviolable sonority scale that assigns a higher sonority rank to fricatives cannot account for the generalizations which are observed in the typology. Following Clements (1990), I assume that the two classes of sounds differ only in terms of the feature [continuant], which is not relevant for sonority.I propose an analysis of obstruent clusters based on Optimality Theory (Prince and Smolensky 1993). The relative harmony (i.e. markedness) of these clusters is formally derived by evaluating them against a set of structural constraints. I propose two OCP constraints, one for each value of the feature [continuant] and a constraint that disallows a stop as first member of the cluster (*SO). Interaction of these constraints with Faithfulness allows to construct the six differentconstraint hierarchies, which account for the six different typological classes of languages. The implicational universals follow from entailment considerations on the rankings established to admit the relevant structures in the typological grammars.
Traffic Sign Recognition Using Deep Learning Methods
Creators: name: Μήτα, Μυρσίνη-Ελένη Αθανασίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2021
Subjects: Αναγνώριση Σημάτων Κυκλοφορίας
Βαθιά Μάθηση
Γερμανικό Σύνολο Δεδομένων Αναγνώρισης Σημάτων Κυκλοφορίας
Traffic Sign Recognition (TSR)
Deep Learning (DL)
German Traffic Sign Recognition Benchmark (GTSRB)

description: Η αναγνώριση πινακίδων κυκλοφορίας είναι απαραίτητη για τα ευφυή συστήματα μεταφορών και τα ευφυή οχήματα. Τα συστήματα αυτά έχουν καθοριστική σημασία για την ανάπτυξη αυτόνομων οχημάτων, ενός δημοφιλούς τομέα που γνωρίζει συνεχή επέκταση. Για την αντιμετώπιση αυτής της πρόκλησης, οι ερευνητές έχουν εμβαθύνει σε διάφορες μεθόδους αναγνώρισης πινακίδων κυκλοφορίας, που κυμαίνονται από τη μηχανική μάθηση έως τις μεθόδους βαθιάς μάθησης . Παρά τις προσπάθειες αυτές, η ποικιλομορφία των πινακίδων κυκλοφορίας σε διάφορες περιοχές, οι περίπλοκες ρυθμίσεις φόντου και οι διακυμάνσεις του φωτισμού εξακολουθούν να αποτελούν σημαντικές προκλήσεις για τη δημιουργία αξιόπιστων συστημάτων αναγνώρισης πινακίδων κυκλοφορίας. Στην παρούσα μελέτη, χρησιμοποιούνται τεχνικές βαθιάς μάθησης για την αναγνώριση πινακίδων κυκλοφορίας, χρησιμοποιώντας το δημόσια διαθέσιμο σύνολο δεδομένων German Traffic Sign Recognition Benchmark (GTSRB). Σχεδιάζεται ένα νευρωνικό δίκτυο και συγκρίνεται με σύγχρονα μοντέλα βαθιάς μάθησης όπως τα ResNet-18, VGG-11 και ConvNeXt για την ταξινόμηση πινακίδων κυκλοφορίας από άποψη ακρίβειας και πολυπλοκότητας.
description: Traffic Sign Recognition (TSR) is essential to Intelligent Transportation Systems (ITS) and intelligent vehicles. These systems are pivotal in developing autonomous vehicles, a popular field experiencing continuous expansion. To address this challenge, researchers have been delving into different methods of traffic sign recognition, ranging from machine learning (ML) to deep learning (DL) methods. Despite these endeavors, the diversity of traffic signs across different regions, intricate background settings, and fluctuations in illumination continues to present considerable challenges to creating dependable traffic sign recognition systems. In this study, DL techniques are employed for traffic sign recognition, utilizing the publicly available German Traffic Sign Recognition Benchmark (GTSRB) dataset. A neural network is designed and compared with state-of-the-art (SOTA) DL models such as ResNet-18, VGG-11, and ConvNeXt for traffic sign classification in terms of accuracy and complexity.
Scorpiops hardwickii
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops hardwickii

description: (5) Scorpiops hardwickii (Gervais, 1843) *
TYPE LOCALITY AND TYPE DEPOSITORY. Nepal, Himalayan Mountain Range; NHMUK.
PROTONYM. Scorpio hardwickii Gervais, 1843.
CHINESE EQUIVALENT. Ǭ氏ẍx.
DISTRIBUTION (◌). Xizang: Lhasa City (“Nyenchen Tanglha Mts.”, probably in Damxung County).
REMARKS. This population is most likely conspecific with S. tibetanus after examining one adult female (Lowe & Tang, 2024) from the material series in Kovařík (2000: 176). It will be addressed in an upcoming paper.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 17, DOI: 10.5281/zenodo.14660932