title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼ÐµÑÐ¾Ð´Ð° Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ ÑÐ·Ð»Ð¾Ð²ÑÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐ¸ÑÐ¾Ð²Ð¸Ð´Ð½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÐÐ¢-ÐÐ¦Ð Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼Ð¸ÐºÑÐ¾Ð ÐÐ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of a method of differential diagnosis of thyroid nodules based on RT-PCR microRNA analysis
Creators: name: ÐÐ½ÑÐ·ÐµÐ²Ð°, ÐÐ°ÑÐ³Ð°ÑÐ¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¼Ð¸ÐºÑÐ¾Ð ÐÐ
ÑÐ°Ðº ÑÐ¸ÑÐ¾Ð²Ð¸Ð´Ð½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ
Ð¾Ð±ÑÐ°ÑÐ½Ð°Ñ ÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ñ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐµÐ¹ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ°Ð·Ð½Ð¾Ð¹ ÑÐµÐ¿Ð½Ð¾Ð¹ ÑÐµÐ°ÐºÑÐ¸ÐµÐ¹ (ÐÐ¢-ÐÐ¦Ð )
ROC-ÐºÑÐ¸Ð²ÑÐµ
Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ°
miRNA
thyroid cancer
RT-qPCR
ROC-curva
diagnostics

description: ÐÐ¸ÐºÑÐ¾Ð ÐÐ â ÐºÐ»Ð°ÑÑ Ð¼Ð°Ð»ÑÑ Ð¼Ð¾Ð»ÐµÐºÑÐ», ÑÐµÐ³ÑÐ»Ð¸ÑÑÑÑÐ¸Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² Ð½Ð° Ð¿Ð¾ÑÑÑÑÐ°Ð½ÑÐºÑÐ¸Ð¿ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¼ ÑÑÐ¾Ð²Ð½Ðµ. ÐÐ½Ð¾Ð³Ð¸Ðµ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´Ð°ÑÑÑÑ ÑÐ°ÑÐ°ÐºÑÐµÑÐ½ÑÐ¼Ð¸ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸ÑÐ¼Ð¸ Ð² ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð¼ Ð¿ÑÐ¾ÑÐ¸Ð»Ðµ Ð¼Ð¸ÐºÑÐ¾Ð ÐÐ, ÑÑÐ¾ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑ ÑÑÐ¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ, ÐºÐ°Ðº Ð½Ð¾Ð²ÑÐ¹ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐ¹ ÐºÐ»Ð°ÑÑ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð°ÑÐºÐµÑÐ¾Ð². Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð°ÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ Ð¾ÑÐµÐ½ÐºÐ° Ð¼ÐµÑÐ¾Ð´Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼Ð¸ÐºÑÐ¾Ð ÐÐ Ð´Ð»Ñ ÑÑÐ¾ÑÐ½ÑÑÑÐµÐ¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ ÑÐ»Ð¾Ð¶Ð½ÑÑ ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ»ÑÑÐ°ÐµÐ² ÑÐ·Ð»Ð¾Ð²ÑÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐ¸ÑÐ¾Ð²Ð¸Ð´Ð½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ Ð² Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ðµ Ð¢ÐÐ. ÐÐ±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾, ÑÑÐ¾ Ð½ÐµÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿Ð°ÑÑ Ñ ÑÐ°Ð·Ð½Ð¾Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐ¼ ÑÑÐ¾Ð²Ð½ÐµÐ¼ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ (ÑÐµÑÐ¸Ð¿ÑÐ¾ÐºÐ½ÑÐµ Ð¿Ð°ÑÑ) Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð²ÑÑÐ¾ÐºÐ¸Ð¼ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¼. ÐÑÑÐ²Ð»ÐµÐ½Ñ ÑÐµÑÐ¸Ð¿ÑÐ¾ÐºÐ½ÑÐµ Ð¿Ð°ÑÑ Ð´Ð»Ñ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°ÑÐ¸Ð¸ Ð½ÐµÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð·Ð¾Ð±Ð° Ð¸ Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹ ÑÐ¸ÑÐ¾Ð²Ð¸Ð´Ð½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ; Ð¿Ð°Ð¿Ð¸Ð»Ð»ÑÑÐ½Ð¾Ð³Ð¾ ÑÐ°ÐºÐ° Ð¸ ÑÐ¾Ð»Ð»Ð¸ÐºÑÐ»ÑÑÐ½Ð¾Ð³Ð¾ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ° Ð¿Ð°Ð¿Ð¸Ð»Ð»ÑÑÐ½Ð¾Ð³Ð¾ ÑÐ°ÐºÐ°; ÑÐ¾Ð»Ð»Ð¸ÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð°Ð´ÐµÐ½Ð¾Ð¼Ñ Ð¸ ÑÐ¾Ð»Ð»Ð¸ÐºÑÐ»ÑÑÐ½Ð¾Ð¹ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ñ.
description: MicroRNA is a class of small molecules that regulate gene expression at the post-transcriptional level; many pathological conditions are accompanied by characteristic changes in the cellular profile of miRNA, which allows us to consider these molecules as a new promising class of biological markers. In this work, the miRNA analysis method in the TAB material was developed to diagnostics of complex cytological cases of thyroid cancer. Some pairs with a multidirectional level of expression (reciprocal pairs) have a high diagnostic index. Reciprocal pairs for differentiation of goiter and thyroid malignant tu-mors were revealed; papillary cancer and follicular papillary cancer; follicular adenoma and follicular carcinoma.