cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Boosting Algorithms for Delivery Time Prediction in Transportation Logistics
Creators: name: Khiari, Jihed
name: Olaverri-Monreal, Cristina
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Travel time is a crucial measure in transportation. Accurate travel time prediction is also fundamental for operation and advanced information systems. A variety of solutions exist for short-term travel time predictions such as solutions that utilize real-time GPS data and optimization methods to track the path of a vehicle. However, reliable long-term predictions remain challenging. We show in this paper the applicability and usefulness of travel time i.e. delivery time prediction for postal services. We investigate several methods such as linear regression models and tree based ensembles such as random forest, bagging, and boosting, that allow to predict delivery time by conducting extensive experiments and considering many usability scenarios. Results reveal that travel time prediction can help mitigate high delays in postal services. We show that some boosting algorithms, such as light gradient boosting and catboost, have a higher performance in terms of accuracy and runtime efficiency than other baselines such as linear regression models, bagging regressor and random forest.
Braiding a flock: winding statistics of interacting flying spins
Creators: name: Caussin, Jean-Baptiste
name: Bartolo, Denis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: When animal groups move coherently in the form of a flock, their trajectories are not all parallel, the individuals exchange their position in the group. In this Letter we introduce a measure of this mixing dynamics, which we quantify as the winding of the braid formed from the particle trajectories. Building on a paradigmatic flocking model we numerically and theoretically explain the winding statistics, and show that it is predominantly set by the global twist of the trajectories as a consequence of a spontaneous symmetry breaking.
Additional file 1 of Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types
Creators: name: Larsson, Peter
name: Pettersson, Daniella
name: Engqvist, Hanna
name: Werner Rönnerman, Elisabeth
name: Forssell-Aronsson, Eva
name: Kovács, Anikó
name: Karlsson, Per
name: Helou, Khalil
name: Parris, Toshima Z.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. OncoPrint conducted by cBioPortal displaying genetic alteration frequency of proteasome genes.
109. Study of pathogenic T-helper cell subsets in Asian Indian patients with Takayasu arteritis
Creators: name: Goel1, Ruchika
name: Punithavathy PM2
name: Babu3, Ramesh
name: Savit B  Prabhu2
name: Jayakanthan  Kabeerdoss1
name: Chanduni  Syed2
name: Joseph4, George
name: Debashish  Danda1
name: Thomas3, Meera
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Relapses and refractory disease are a challenge in management of patients with Takayasu arteritis (TAK). In the present study, we quantified pathogenic CD4+memory T-helper cells bearing surface markers CD161 and/or p-glycoprotein (MDR1) in patients with TAK. Methods: Peripheral blood mononuclear cells of 21 patients with TAK and 16 age-matched controls were stained with anti-CD3, anti-CD4, anti-CD45RA-, anti-CD161 and anti-p-glycoprotein antibodies and subjected to flow cytometry by FACS ARIAIII. Follow up sample was immunophenotyped for 18 patients. Intracellular staining for interleukin-17 and interferon-Ƴ was performed for 18 patients at 2 visits and 11 controls. The clinical details of patients were recorded prospectively. Surgical arterial biopsies of 6 TAK patients and 5 non-inflammatory controls were subjected to immunohistochemistry with anti-CD161 and anti-p-glycoprotein. Results: Among memory CD4+ T cell pool, frequency of MDR1+ and CD161+MDR1 cells was significantly higher in TAK than in controls at baseline visit (p=0.002 and 0.01 respectively). After stimulation, frequency of CD161+cells with intracellular IFN-Ƴ expression was higher in TAK than controls (p=0.028). Modal fluorescence intensity of CD161+MDR1+ CD45RA-CD4+ cells normalized to the MFI value of MDR1+CD161-CD45RA-CD4+ subset was higher in patients with active disease as compared with stable disease (p=0.041). Among 6 surgical biopsies from patients with TAK, 4 and 5 stained positive for CD161 and MDR1 respectively. Only one of the 5 control biopsy stained positive for CD161 and MDR1. On serial sampling, frequency of MDR1+ and CD161+MDR1+ memory CD4+ cells decreased significantly in only patients who had complete/partial response to treatment at 6 months (p=0.047 and 0.02 respectively). Conclusion: MDR1+ and MDR1+CD161+CD4+ memory T-helper cells are increased in patients with TAK. Decrease in frequency of these cells is associated with response to treatment during subsequent follow up. Disclosures: None. This study is funded by CMC, Intramural and Indian Rheumatology Association research grant to Ruchika Goel. Figure 1. Frequency of MDR1+ and CD161+MDR1+ T helper cells in TAK patients and healthy controls (HC)
Additional file 2 of Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types
Creators: name: Larsson, Peter
name: Pettersson, Daniella
name: Engqvist, Hanna
name: Werner Rönnerman, Elisabeth
name: Forssell-Aronsson, Eva
name: Kovács, Anikó
name: Karlsson, Per
name: Helou, Khalil
name: Parris, Toshima Z.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Supplementary Figure 2. Stacked bar chart depicting the number of amplifications per PSM gene in the 32 cancer types. Supplementary Figure 3. PSM focal amplification and gene expression associated with patient survival (OS and PFI). Supplementary Figures 4. Forest plots depicting multivariable Cox regression analysis and prognostic relevance (OS and PFI) PSM gene expression patterns in UVM patients and PSM gene (PSMA1 and PSMD2) expression patterns and survival risk in 33 cancer types. HR <1 depicts the association between high PSM gene expression and decreased risk of survival, whereas HR >1 illustrates the association between high PSM gene expression and increased risk of survival.
Improving Sequential Latent Variable Models with Autoregressive Flows
Creators: name: Marino, Joseph
name: Chen, Lei
name: He, Jiawei
name: Mandt, Stephan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: We propose an approach for improving sequence modeling based on autoregressive normalizing flows. Each autoregressive transform, acting across time, serves as a moving frame of reference, removing temporal correlations, and simplifying the modeling of higher-level dynamics. This technique provides a simple, general-purpose method for improving sequence modeling, with connections to existing and classical techniques. We demonstrate the proposed approach both with standalone flow-based models and as a component within sequential latent variable models. Results are presented on three benchmark video datasets, where autoregressive flow-based dynamics improve log-likelihood performance over baseline models. Finally, we illustrate the decorrelation and improved generalization properties of using flow-based dynamics.
description: Published at Machine Learning Journal
Genotoxic and genoprotective effects of phytoestrogens: a systematic review
Creators: name: Tagorti, Ghada
name: Yalçın, Burçin
name: Güneş, Merve
name: Kurşun, Ayşen Yağmur
name: Kaya, Bülent
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Phytoestrogens are xenoestrogens found in plants with a myriad of health benefits. However, various studies reported the genotoxic effects of these substances. Thus, we reviewed in vitro and in vivo studies published in PubMed, Scopus, and Web of Science to evaluate the genotoxic and the genoprotective potential of phytoestrogens. Only studies written in English and intended to study commercially available phytoestrogens were included. The screening was performed manually. Moreover, the underlying mechanism of action of phytoestrogens was described. Around half of those studies (43%) reported genoprotective results. However, several studies revealed positive results for genotoxicity with specific model organisms and with dose/concentration dependence. The assessment of the selected articles showed substantial differences in the used concentrations and a biphasic response was recorded in some phytoestrogens. As far as we know, this is the first study to assess the genotoxic and genoprotective effects of phytoestrogens systematically.
title: Anticodes and error-correcting for digital data transmission
Creators: name: Khadem-Zadeh, A.
Publisher: name: University of Kent
Year: 2023

description: The work reported in this thesis is an investigation in the field of error-control coding. This subject is concerned with increasing the reliability of digital data transmission through a noisy medium, by coding the transmitted data. In this respect, an extension and development of a method for finding optimum and near-optimum codes, using N.m digital arrays known as anticodes, is established and described. The anticodes, which have opposite properties to their complementary related error-control codes, are disjoined fron the original maximal-length code, known as the parent anticode, to leave good linear block codes. The mathematical analysis of the parent anticode and as a result the mathematical analysis of its related anticodes has given some useful insight into the construction of a large number of optimum and near-optimum anticodes resulting respectively in a large number of optimum and near-optimum codes. This work has been devoted to the construction of anticodes from unit basic (small dimension) anticodes by means of various systematic construction and refinement techniques, which simplifies the construction of the associated linear block codes over a wide range of parameters. An extensive list of these anticodes and codes is given in the thesis. The work also has been extended to the construction of anticodes in which the symbols have been chosen from the elements of the finite field GF(q), and, in particular, a large number of optimum and near-optimum codes over GF(3) have been found. This generalises the concept of anticodes into the subject of multilevel codes.
Encourager l'innovation tout en assurant la stabilité : Les enjeux de la régulation des fintech au Maroc
Creators: name: BENNIS, Laila
name: ANGUER, Nour-Eddine
Publisher: name: Zenodo
Year: 2023
Subjects: Innovation ; Fintech ; Risques ; Règlementation ; Stabilité financière.

description: L'innovation dans le domaine des fintech englobe une gamme de nouvelles idées, de méthodes et de technologies qui perturbent et transforment les services financiers traditionnels. Cette innovation a poussé à l'émergence des fintech, résultant de l'intersection entre les avancées technologiques et les besoins changeants du secteur financier. Les fintech offrent de nombreuses opportunités d'innovation et de transformation des services financiers, mais elles sont également exposées à certains risques. Aujourd'hui, la principale préoccupation des États réside dans la recherche d'un modèle approprié pour réguler ces nouveaux acteurs, afin de protéger les déposants et de préserver la stabilité financière. Le présent document vise à examiner la réglementation en vigueur au Maroc concernant les fintech, qui jouent un rôle essentiel dans l'innovation technologique dans le secteur financier et suscitent des questions relatives à la réglementation.
Inverse iteration quantum eigensolvers assisted with a continuous variable
Creators: name: He, Min-Quan
name: Zhang, Dan-Bo
name: Wang, Z. D.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The capacity for solving eigenstates with a quantum computer is key for ultimately simulating physical systems. Here we propose inverse iteration quantum eigensolvers, which exploit the power of quantum computing for the classical inverse power iteration method. A key ingredient is constructing an inverse Hamiltonian as a linear combination of coherent Hamiltonian evolution. We first consider a continuous-variable quantum mode (qumode) for realizing such a linear combination as an integral, with weights being encoded into a qumode resource state. We demonstrate the quantum algorithm with numerical simulations under finite squeezing for various physical systems, including molecules and quantum many-body models. We also discuss a hybrid quantum-classical algorithm that directly sums up Hamiltonian evolution with different durations for comparison. It is revealed that continuous-variable resources are valuable for reducing the coherent evolution time of Hamiltonians in quantum algorithms.
description: 13 + 6 pages, close to published version
Towards Runtime Verification via Event Stream Processing in Cloud Computing Infrastructures
Creators: name: Cotroneo, Domenico
name: De Simone, Luigi
name: Liguori, Pietro
name: Natella, Roberto
name: Scibelli, Angela
Publisher: name: arXiv
Year: 2020
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Software bugs in cloud management systems often cause erratic behavior, hindering detection, and recovery of failures. As a consequence, the failures are not timely detected and notified, and can silently propagate through the system. To face these issues, we propose a lightweight approach to runtime verification, for monitoring and failure detection of cloud computing systems. We performed a preliminary evaluation of the proposed approach in the OpenStack cloud management platform, an "off-the-shelf" distributed system, showing that the approach can be applied with high failure detection coverage.
description: International Workshop on Artificial Intelligence for IT Operations, 14 December 2020
FAR: A General Framework for Attributional Robustness
Creators: name: Ivankay, Adam
name: Girardi, Ivan
name: Marchiori, Chiara
name: Frossard, Pascal
Publisher: name: arXiv
Year: 2020
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Attribution maps are popular tools for explaining neural networks predictions. By assigning an importance value to each input dimension that represents its impact towards the outcome, they give an intuitive explanation of the decision process. However, recent work has discovered vulnerability of these maps to imperceptible adversarial changes, which can prove critical in safety-relevant domains such as healthcare. Therefore, we define a novel generic framework for attributional robustness (FAR) as general problem formulation for training models with robust attributions. This framework consist of a generic regularization term and training objective that minimize the maximal dissimilarity of attribution maps in a local neighbourhood of the input. We show that FAR is a generalized, less constrained formulation of currently existing training methods. We then propose two new instantiations of this framework, AAT and AdvAAT, that directly optimize for both robust attributions and predictions. Experiments performed on widely used vision datasets show that our methods perform better or comparably to current ones in terms of attributional robustness while being more generally applicable. We finally show that our methods mitigate undesired dependencies between attributional robustness and some training and estimation parameters, which seem to critically affect other competitor methods.
Seriös oder nicht? Die individuelle Prüfung der Qualität von Zeitschriften an der TIB
Creators: name: Schmeja, Stefan
name: Kändler, Ulrike
Publisher: name: Heidelberg : Universitätsbibliothek
Year: 2023
Subjects: subject: Open-Access-Zeitschriften
subject: Predatory Journals
subject: Open-Access-Beratung
subject: Open-Access-Finanzierung
subject: 020

description: Die Frage nach der Qualität von Open-Access-Zeitschriften stellt sich an der TIB sowohl bei der Beratung von Autor:innen als auch bei der Förderung durch einen Publikationsfonds. Wenn eine Zeitschrift nicht im Directory of Open Access Journals (DOAJ) gelistet ist und auch nicht eindeutig unseriös erscheint, wird sie individuell anhand unterschiedlicher Kriterien geprüft. In diesem Beitrag stellen wir die benutzten Kriterien vor und schildern unsere Erfahrung bei der Einschätzung.
Additional file 1 of Intravenous dantrolene in hypermetabolic syndromes: a survey of the U.S. Veterans Health Administration database
Creators: name: Caroff, Stanley N.
name: Roberts, Christopher B.
name: Rosenberg, Henry
name: Tobin, Joseph R.
name: Watt, Stacey
name: Mashman, Darlene
name: Riazi, Sheila
name: Berkowitz, Rosalind M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplementary Table 1. Diagnostic Codes (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM]).
Development of a molecular marker for Arbuscular Mycorhizzal Fungae environmental tracing
Creators: name: Simone, Marcolini
Publisher: name: Zenodo
Year: 2023

description: Presentation of my doctoral project to the faculty members of Sant'Anna School of Advanced Studies. The project is titled: "Development of a molecular marker for Arbuscular Mycorhizzal Fungae environmental tracing".
107. Method Development for the Detection of Proteinase 3-specific B Cells in Granulomatosis with Polyangiitis
Creators: name: Bonasia1, Carlo
name: Wayel Abdulahad1, 2
name: Bos1, Nicolaas
name: Heeringa2, Peter
name: Rutgers1, Abraham
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Granulomatosis with polyangiitis (GPA) is a severe, relapsing, autoimmune disease predominantly affecting the small blood vessels of the airways and kidneys. In GPA, an autoimmune response is present against proteinase 3 (PR3), which is a protein primarily located in the granules of neutrophils. Moreover, GPA is considered to be a B cell-mediated autoimmune disease since pathogenic PR3-anti-neutrophil cytoplasmic antibodies are present and B cell depletion therapy is efficacious. Unraveling the biology of PR3-specific B cells is of high interest because this may provide insights into the differentiation and maturation process of PR3-specific B cells, and may aid in the identification of novel therapeutic targets and relapse risk biomarkers. However, sensitive techniques to specifically detect, isolate, and characterize these low-frequency cells are lacking. Therefore, we aimed to develop a flow cytometry-based detection method for the specific identification and isolation of PR3-specific B cells from the peripheral blood of GPA patients. Methods: Native human PR3 was fluorescently labeled with Alexa Fluor 647 (AF647) or R-Phycoerythrin (PE) and their binding characteristics to anti-human PR3, anti-human elastase, and anti-human epithelial glycoprotein-2 hybridoma cells were determined by flow cytometry. Freshly isolated or frozen peripheral blood mononuclear cells (PBMCs) from GPA patients in remission (n=5), with active disease (n=1), and healthy donors (n=2) were dual stained with PR3-AF647 and PR3-PE, and the presence of PR3-specific B cells was studied by flow cytometry. Results: PR3-AF647 and PR3-PE separately bound to anti-human PR3 hybridoma cells specifically. Combining PR3-AF647 and PR3-PE resulted in higher specificity to anti-human PR3 hybridoma cells and lower background staining. PR3-AF647+PR3-PE+ B cells could be detected from the PBMCs of GPA patients and healthy donors and the frequency of PR3-AF647+PR3-PE+ B cells within the total B cell population was higher in GPA patients (mean: 0.58%; 0.02-1.48) compared to healthy donors (mean: 0.12%; 0.04, 0.2,). Conclusions: These preliminary data suggest that circulating PR3-specific B cells can be detected in GPA patients and healthy donors with a PR3-AF647/PR3-PE dual staining. However, whether the detected B cells can produce PR3-anti-neutrophil cytoplasmic antibodies, thereby confirming the validity of the detection method, needs to be determined. Disclosures: None
Bayesian sample size determination using commensurate priors to leverage pre-experimental data
Creators: name: Zheng, Haiyan
name: Jaki, Thomas
name: Wason, James M. S.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Methodology (stat.ME)
subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: This paper develops Bayesian sample size formulae for experiments comparing two groups. We assume the experimental data will be analysed in the Bayesian framework, where pre-experimental information from multiple sources can be represented into robust priors. In particular, such robust priors account for preliminary belief about the pairwise commensurability between parameters that underpin the historical and new experiments, to permit flexible borrowing of information. Averaged over the probability space of the new experimental data, appropriate sample sizes are found according to criteria that control certain aspects of the posterior distribution, such as the coverage probability or length of a defined density region. Our Bayesian methodology can be applied to circumstances where the common variance in the new experiment is known or unknown. Exact solutions are available based on most of the criteria considered for Bayesian sample size determination, while a search procedure is described in cases for which there are no closed-form expressions. We illustrate the application of our Bayesian sample size formulae in the setting of designing a clinical trial. Hypothetical data examples, motivated by a rare-disease trial with elicitation of expert prior opinion, and a comprehensive performance evaluation of the proposed methodology are presented.
description: A submitted paper formatted with the double spacing, including 34 pages, 4 figures, 1 table
Additional file 1 of TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome
Creators: name: Perez-Rivas, Luis Gustavo
name: Simon, Julia
name: Albani, Adriana
name: Tang, Sicheng
name: Roeber, Sigrun
name: Assié, Guillaume
name: Deutschbein, Timo
name: Fassnacht, Martin
name: Gadelha, Monica R.
name: Hermus, Ad R.
name: Stalla, Günter K.
name: Tichomirowa, Maria A.
name: Rotermund, Roman
name: Flitsch, Jörg
name: Buchfelder, Michael
name: Nasi-Kordhishti, Isabella
name: Honegger, Jürgen
name: Thorsteinsdottir, Jun
name: Saeger, Wolfgang
name: Herms, Jochen
name: Reincke, Martin
name: Theodoropoulou, Marily
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Cancer

description: Additional file 1. Supplementary Table 1: Description of study cohort. Supplementary Table 2: Primers used for TP53 amplification and Sanger sequencing. Supplementary Table 3: Common TP53 variants in the study cohort. Supplementary Table 4: Comparison of TP53 mutant versus TP53 wild type group. Supplementary Figure 1. Chromatograms showing the TP53 variants found in the corticotroph tumor of patient #1 and #8 (Table 1). A. The variant c.398T>A was present in homozygocity in the tumor and absent in the blood. B. The variant c.1009C>G is detected in all available surgical specimens in this patient. First and 2nd surgeries were Cushing’s disease tumors and 4th and 5th CTP-BADX/NS.
Accelerated Additive Schwarz Methods for Convex Optimization with Adaptive Restart
Creators: name: Park, Jongho
Publisher: name: arXiv
Year: 2020
Subjects: subject: Optimization and Control (math.OC)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N55, 65B99, 65K15, 90C25

description: Based on an observation that additive Schwarz methods for general convex optimization can be interpreted as gradient methods, we propose an acceleration scheme for additive Schwarz methods. Adopting acceleration techniques developed for gradient methods such as momentum and adaptive restarting, the convergence rate of additive Schwarz methods is greatly improved. The proposed acceleration scheme does not require any a priori information on the levels of smoothness and sharpness of a target energy functional, so that it can be applied to various convex optimization problems. Numerical results for linear elliptic problems, nonlinear elliptic problems, nonsmooth problems, and nonsharp problems are provided to highlight the superiority and the broad applicability of the proposed scheme.
description: 20 pages, 8 figures
Nosotras
Creators: name: Martínez Quiroga, Pilar
Publisher: name: No Publisher Supplied
Year: 2011

description: In my dissertation I analyze how Spanish women writers have used the historical and autobiographical novel in order to reinvent both personal lives and national histories and to reconfigure new feminine communities. While the primary goal is Spanish literature, I approach the definition of women’s community from a multidisciplinary perspective that includes political, sociological, economic, religious, and anthropological issues, paying special attention to instances of resistance and social change reflected in recent narratives written by Spanish women. Counteracting previous metaphysical and religious conceptions of a homogeneous community, I analyze the reflection of a multiple, plural feminine subject, as found in different spaces and relationships. I begin the dissertation by exploring the specific family ties created between women: thus, while chapter one studies the bonds between mothers and daughters, chapter two focuses on the relationship between sisters. The rest of the dissertation moves from the private to the public realm. In chapter three, I analyze how feminine friendship is the first form of public association that allows for the creation of a women political community. The fourth chapter deals with the creation of communities of feminine readers and authors, and how they are shaped by editorial ideologies and practices. In chapter five, I analyze the intersections between feminism and nationalism in the Historic Communities of Spain: Catalonia, Basque Country, and Galicia.
MPEC 2023-U149 : 2023 UC3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 UC3

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Alpinia officinarum Rhizome ameliorates the UVB induced photoaging through attenuating the phosphorylation of AKT and ERK
Creators: name: Jung, Jong Min
name: Kwon, Oh Yun
name: Choi, Jong Kyu
name: Lee, Seung Ho
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
title: Building the foundations of sustainable environmental management
title: Understanding the influence of natural capital on ecosystem services
titleType: Subtitle
Creators: name: Linney, George
Publisher: name: Lancaster University
Year: 2023
Subjects: ecosystem service
natural capital
Context
trade-offs
Evidence tool

description: Global indicators of ecosystem extent and condition have declined by 47%, relative to their earliest estimated states. Natural capital is the worlds’ stocks of these natural assets, which supply a wide range of ecosystem services that directly or indirectly produce value for people. This decline in our natural capital is likely to have repercussions for the ecosystem services it supplies. To support and inform sustainable and effective environmental management decisions for the provision of our vital ecosystem services we must fully understand the linkages between them and natural capital. Yet many existing approaches only assess a limited number of ecosystem services and natural capital assets, and therefore miss important synergies and trade-offs. Furthermore, there has been very little exploration into the context dependency of these linkages and the evidence underlying them; natural capital to ecosystem service linkages may be of different relevance to decision makers depending on their desired application. This thesis follows the creation of the Linking Natural Capital Attribute Groups to Ecosystem Services (LiNCAGES) platform to support collation, exploration and synthesis of evidence on linkages between natural capital and ecosystem services and its communication in environmental decision making. The thesis shows how the LiNCAGES platform allows for the holistic investigation of natural capital and ecosystem service linkages while accounting for the context dependency of a user’s decisions. Furthermore, this thesis reveals how accounting for relationships between multiple natural capital attributes can reveal new indirect trade-offs and synergies between ecosystem services and how these are affected by context dependency. Additionally, the thesis highlights the importance of understanding the strengths and limitations of evidence on natural capital that underpins maps of ecosystem service provision, which are frequently used to support environmental decisions. Maps of present and future ecosystem service provision created using evidence from the literature, expert scoring and an existing model were found to vary considerably by the region, ecosystem service, and future scenario mapped. The work presented in this thesis provides new insight into the complexities and context dependencies in natural capital to ecosystem service linkages and relationships between natural capital attributes, as well as in the evidence used to communicate such linkages via ecosystem service provision maps. This deeper understanding contributes to the support of sustainable and effective environmental management decisions necessary for the preservation of our vital ecosystem services.
106. Elevated STAT3/PIM1 Expression in T Cell Subsets of Granulomatosis with Polyangiitis Patients
Creators: name: Nanthicha Inrueangsri1
name: Reitsema2, Rosanne
name: Bijma1, Theo
name: Wayel Abdulahad1, 2
name: Jan-Stephan Sanders3
name: Brouwer2, Elisabeth
name: Rutgers2, Abraham
name: Heeringa1, Peter
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Granulomatosis with polyangiitis (GPA) is an autoimmune disease characterized by inflammation of the microvasculature in various organs. Aberrations in several T cell subsets, both numerical and functional, have been identified in GPA patients. However, their significance for GPA pathogenesis remains unclear. Here, we applied single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) to capture the transcriptional signatures of T cell subsets associated with active disease in GPA. Methods: PBMCs of active GPA patients (n=3) and healthy age-and sex-matched donors (n=3) were subjected to droplet-based scRNA-seq (10x Genomics). Analysis of scRNA-seq data was performed using BioTuring Browser (https://bioturing.com/bbrowser) and Seurat package. Validation of differentially expressed genes was subsequently performed by quantitative PCR (qPCR) on bulk flow-sorted naïve CD4+ T cells (CD4+Tnaive), CD4+ effector memory T cells (CD4+TEM), and CD4+ regulatory T cells (CD4+Tregs) derived from active and remission GPA patients and healthy donors. Results: Differential expression analysis of scRNA-seq datasets revealed that mRNA expression levels of the serine/threonine kinase; proviral integration site for Moloney murine leukemia virus (PIM1) and its transcription factor STAT3 were upregulated in T cells from active GPA patients including subpopulations of CD4+Tnaive, CD4+TEM, and CD4+Tregs. qPCR analysis of bulk flow-sorted CD4+Tnaive, CD4+TEM, and CD4+Tregs of active GPA patients confirmed elevated expression levels of PIM1 in all subsets compared to those of healthy controls whereas STAT3 expression was significantly upregulated in CD4+Tnaive and CD4+TEM subsets. Interestingly, qPCR analysis of CD4+Tnaive and CD4+TEM from remission patients demonstrated that PIM1 expression was still upregulated suggesting persistent T cell activation (figure 1). Conclusions: These data indicate that the STAT3/PIM1 signaling pathway is activated in T cells from GPA patients. Interestingly, previous studies have shown that PIM1 mediated phosphorylation of FOXP3 impairs the suppressive capacity of Tregs which may explain the defective Treg function known to exist in GPA patients (1,2). Further functional studies are warranted to determine whether PIM1 inhibition is a rational therapeutic approach in GPA. Disclosures: None Figure 1. PIM1 mRNA expression is upregulated in bulk sorted CD4+TEM in GPA patients with active disease and in remission compared to healthy controls. Kruskal-Wallis test (p<0.05).
105. Identification of central tolerance checkpoints for autoreactive proteinase 3+ B cells in human bone marrow
Creators: name: Alvise Berti1,2,6
name: Tomasi2, Michele
name: Pesce3, Isabella
name: Lista4, Enrico
name: Guella4, Anna
name: Bortolotti1, Roberto
name: Paolazzi1, Giuseppe
name: Hillion5, Sophie
name: Specks6, Ulrich
name: Grandi2, Guido
name: Divi Cornec5, 6
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: Background: Autoreactive proteinase 3 (PR3+) B cells have recently been phenotypically and functionally characterized, and the presence of defective central antigen-independent and peripheral antigen-dependent checkpoints in patients with ANCA-associated vasculitis (AAV) has been shown. This work aimed to investigate the central tolerance-checkpoint controlling immature PR3+ B cells in the bone marrow (BM), before their migration into the periphery as transitional B cells. Methods: By flow-cytometry, using PR3 as ligand to target autoreactive PR3+ B cells, we investigated 1) the presence and the specific phenotypic features of PR3+ B cells in BM mononuclear cells (BMMC) of non-vasculitis controls (No-AAV), comparing them to paired peripheral blood mononuclear cells (PBMC) of No-AAV and PBMC of PR3-AAV patients, and 2) the central tolerance-checkpoints for PR3+ B cells. Results: The proportion of PR3+ B cells within BMMC (median [IQR25-75%]; 1.98%[1.77-2.75]) was higher than within PBMC of No-AAV (0.9%[0.63-1.44], p<0.01 by paired comparison) and similar to their proportion within PBMC of PR3-AAV patients (1.82%[1.66-3.21]; p>0.05). When focusing on immature/transitional CD24++CD38++B cells only in No-AAV, we observed distinct phenotypes within BMMC versus PBMC (i.e. higher proportion of CD27-CD10+ and lower expression of CD21, IgD, IgM within BMMC versus PBMC), representing two separate developmental steps of B cell maturation. Within CD24++CD38++ B cells, BMMC contained the greatest proportion of PR3+ B cells as compared to PBMC (3.35%[1.99-4.92] versus 1.23%[0.62-1.55], p<0.01). We observed a significant decline of the PR3+ fraction from T1-like/immature subset (IgD-IgM+; 2.80%[1.23-4.02]) to T2-like/early transitional subset (IgD+IgM+; 1.76%[0.96-2.68], p<0.01) in BMMC, while no significant reduction was observed between the latter subset and the transitional compartment of PBMC (1.26%[0.62-1.56], p>0.05). Conclusions: To prevent PR3-related autoimmunity, autoreactive PR3+ B cells pass a stringent selection in the BM, and their removal by central tolerance-checkpoint activity occurs mainly between T1-like/immature to T2-like/early transitional B cells of BMMC. Disclosures: Specks have received research grants from Roche/Genentech. Figure 1.
Measuring the Cosmological 21 cm Monopole with an Interferometer
Creators: name: Presley, Morgan
name: Liu, Adrian
name: Parsons, Aaron
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: A measurement of the cosmological 21 cm signal remains a promising but as-of-yet unattained ambition of radio astronomy. A positive detection would provide direct observations of key unexplored epochs of our cosmic history, including the cosmic dark ages and reionization. In this paper, we concentrate on measurements of the spatial monopole of the 21 cm brightness temperature as a function of redshift (the "global signal"). Most global experiments to date have been single-element experiments. In this paper, we show how an interferometer can be designed to be sensitive to the monopole mode of the sky, thus providing an alternate approach to accessing the global signature. We provide simple rules of thumb for designing a global signal interferometer and use numerical simulations to show that a modest array of tightly packed antenna elements with moderately sized primary beams (full-width-half-max of $\sim$40$^\circ$) can compete with typical single-element experiments in their ability to constrain phenomenological parameters pertaining to reionization and the pre-reionization era. We also provide a general data analysis framework for extracting the global signal from interferometric measurements (with analysis of single-element experiments arising as a special case) and discuss trade-offs with various data analysis choices. Given that interferometric measurements are able to avoid a number of systematics inherent in single-element experiments, our results suggest that interferometry ought to be explored as a complementary way to probe the global signal.
description: 21 pages, 13 figures; Replaced to match accepted ApJ version: minor revisions throughout + expanded discussion in Section 2.1 to clarify the importance of curved and finite sky effects in making an interferometer sensitive to the monopole
Moving through motherhood: Co-designing dance for maternal wellbeing
Creators: name: Cluderay, Emily-Rose
Publisher: name: College of Health, Psychology and Social Care (University of Derby)
Year: 2022
Subjects: Maternal health
Maternal wellbeing
Dance and health
Dance and wellbeing
Community dance practice
Participatory arts
Arts interventions
postnatal

description: This thesis contributes to the growing body of evidence discussing the use of participatory arts to contribute to health and wellbeing outcomes. The original research contained in this work discusses the use of arts-based interventions with a maternal population and seeks to understand how dance and movement might be used with first time mothers in the postnatal period, with the overarching research question being ‘What contribution might dance make to enhancing maternal wellbeing?’. The research employed an iterative mixed methods approach, incorporating (i) a systematic review and meta synthesis exploring the evidence base for arts-based interventions across the perinatal period; (ii) a qualitative study utilising co-design, in which a group of first time mothers took part in focus groups and practical dance workshops; (iii) and a thematic analysis of the qualitative data from this process. It was found that there is a lack of peer-reviewed research into the impact of arts-based interventions for a maternal population. Whilst the published research is of varying degrees of methodological rigour and reporting of data, some common themes around the social, psychological, and emotional benefits were identified using meta-synthesis. Thematic analysis from the co-design study highlighted three key challenges to wellbeing in the maternal period: searching for calm; motherhood threatens wellbeing; and baby takes over. Participants reported that engaging in a dance-based intervention in the postnatal period provided: an inner energy; a physical vocabulary; a means of conquering baby brain and forming sisterhood beyond baby. Finally, a blueprint for an online dance-based intervention to improve wellbeing in the postnatal period was created, featuring a suite of resources including online dance sessions, reflective journaling, peer support, and self-directed movement resources.
Semantic and Relational Spaces in Science of Science: Deep Learning Models for Article Vectorisation
Creators: name: Kozlowski, Diego
name: Dusdal, Jennifer
name: Pang, Jun
name: Zilian, Andreas
Publisher: name: arXiv
Year: 2020
Subjects: subject: Social and Information Networks (cs.SI)
subject: Machine Learning (cs.LG)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Over the last century, we observe a steady and exponentially growth of scientific publications globally. The overwhelming amount of available literature makes a holistic analysis of the research within a field and between fields based on manual inspection impossible. Automatic techniques to support the process of literature review are required to find the epistemic and social patterns that are embedded in scientific publications. In computer sciences, new tools have been developed to deal with large volumes of data. In particular, deep learning techniques open the possibility of automated end-to-end models to project observations to a new, low-dimensional space where the most relevant information of each observation is highlighted. Using deep learning to build new representations of scientific publications is a growing but still emerging field of research. The aim of this paper is to discuss the potential and limits of deep learning for gathering insights about scientific research articles. We focus on document-level embeddings based on the semantic and relational aspects of articles, using Natural Language Processing (NLP) and Graph Neural Networks (GNNs). We explore the different outcomes generated by those techniques. Our results show that using NLP we can encode a semantic space of articles, while with GNN we are able to build a relational space where the social practices of a research community are also encoded.
MPEC 2023-U150 : 2023 UD3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 UD3

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Biofilm of Klebsiella pneumoniae minimize phagocytosis and cytokine expression by macrophage cell line
Creators: name: Rathore, Sudarshan Singh
name: Cheepurupalli, Lalitha
name: Gangwar, Jaya
name: Raman, Thiagarajan
name: Ramakrishnan, Jayapradha
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Table S1. Statistical analysis for heat inactivated biofilms. t-test was performed for the heat inactivated biofilms using an incubator and water bath (Fig. 2).
title: A Man's Home is His Castle: A Look at the Relationship Between Fathers and Children in the Novels of Jane Austen
Creators: name: Johnson-Parries, Miranda M.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2003

description: In western society, the father is one of, if not the most, significant roles possible for a man. In the 18th C bourgeois family, he was especially crucial. In the novels of Jane Austen, the father, even when absent, is a central figure: Dead fathers influence their children by their lack of planning and absence, while a physically present, but mentally distant father has much the same effect. I will analyze how seemingly peripheral male characters within Jane Austen's novels react to their stations in life and try to manipulate them in a similar way to Austen's much analyzed and lauded female characters.

Furthermore, I propose that the hidden restrictions in the different aspects of manhood create a lifestyle that is as constricting as that of the obviously narrow female bourgeois sphere. As men try to negotiate and succeed within the patriarchy, they often find the multiple responsibilities associated with manhood and masculinity to be a burden rather than a badge of honor. Traditionally, our society views the father as the hero of his family: a hero who is strong and silent, intelligent and shrewd, and capable of great passion. If a man fails to measure up to all of these essential qualities, he is unfit for his place within the patriarchal structure. I will discuss how the absence of certain of these qualities leads to difficulties for fathers and their families in the Austen novels.
On auto and hetero Backlund transformations for the Henon-Heiles systems
Creators: name: Tsiganov, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider a canonical transformation of parabolic coordinates on the plain and suppose that this transformation together with some additional relations may be considered as a counterpart of the auto and hetero Bäcklund transformations associated with the integrable Hénon-Heiles systems.
description: 7 pages, LaTeX with AMS fonts, in this version we add an explicit expression for the B\"acklund transformation