cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Global well-posedness of 2D nonlinear Boussinesq equations with mixed partial viscosity and thermal diffusivity
Creators: name: Chen, Chao
name: Liu, Jitao
Publisher: name: arXiv
Year: 2016
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we discuss with the global well-posedness of 2D anisotropic nonlinear Boussinesq equations with any two positive viscosities and one positive thermal diffusivity. More precisely, for three kinds of viscous combinations, we obtain the global well-posedness without any assumption on the solution. For other three difficult cases, under the minimal regularity assumption, we also derive the unique global solution. To the authors' knowledge, our result is new even for the simplified model.
description: 21 pages
Structure-activity relationship of antioxidant prenylated (iso)flavonoid-type compounds: quantum chemistry and molecular docking studies
Creators: name: Boulebd, Houssem
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Prenylated (iso)flavonoid-type compounds are a subclass of natural flavonoids that have been reported to exhibit good antioxidant properties. In the present paper, the structure–activity relationship of three typical prenylated (iso)flavonoids namely 8-prenyldaidzein (Per), Licoflavone (Lic), and erysubin F (Ery) have been determined using DFT (density functional theory)-based calculations and molecular docking studies. As result, the CH bond of the prenyl substituent was found to be the most thermodynamically favorable site for trapping free radicals in the gas phase and lipid physiological environments. While the OH bond of the B-ring seems to be more reactive in water. HAT (hydrogen atom transfer) and SPLET (sequential proton loss electron transfer) play a decisive role in the antiradical activity of the studied compounds in lipid and polar physiological environments, respectively. All of the studied compounds exhibit strong binding affinity to both xanthine oxidase and inducible nitric oxide synthase enzymes by forming several hydrogen bonds and hydrophobic interactions with their respective catalytic sites. These results suggest that (iso)flavonoid-type compounds are promising radical scavengers and antioxidants. Communicated by Ramaswamy H. Sarma.
TiO2 nanotubes with laterally spaced ordering enable optimized hierarchical structures with significantly enhanced photocatalytic H2 generation
Creators: name: Nguyen, Nhat Truong
name: Ozkan, Selda
name: Hwang, Imgon
name: Mazare, Anca
name: Schmuki, Patrik
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In the present work we grow self-organized TiO2 nanotube arrays with a defined and controlled regular spacing between individual nanotubes. These defined intertube gaps allow to build up hierarchical 1D-branched structures, conformally coated on the nanotube walls using a layer by layer nanoparticle TiO2 decoration of the individual tubes, i.e. having not only a high control over the TiO2 nanotube host structure but also on the harvesting layers. After optimizing the intertube spacing, we build host-guest arrays that show a drastically enhanced performance in photocatalytic H2 generation, compared to any arrangement of conventional TiO2 nanotubes or conventional TiO2 nanoparticle layers. We show this beneficial effect to be due to a combination of increased large surface area (mainly provided by the nanoparticle layers) with a fast transport of the harvested charge within the passivated 1D nanotubes. We anticipate that this type of hierarchical structures based on TiO2 nanotubes with adjustable spacing will find even wider application, as they provide an unprecedented controllable combination of surface area and carrier transport.
Market Analysis Brazil: BUS 35
Creators: name: Market Analysis
Publisher: name: Roper Center for Public Opinion Research
Year: 2023

description: Ownership of appliances/luxuries (1); social class (1); government should force companies to act responsibly (1); trust in institutions to benefit society (1); capacity of institutions to solve problems in society (1); responsibility of energy companies (1); economy and equality better/worse in the last twenty years (1); optimistic about progress over the next twenty years (1); performance rating of institutions at solving problems in society (1); opinions on other countries (2); views on free market capitalism (1); equal distribution of economic development (1); election of President Obama in 2008 (1); personal body image (1).
A study of motorcycle crashes in Victoria 1983-1987
Creators: name: Bui, Bill B. D.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Tidal Features around Galaxies in Cosmological Simulations
Creators: name: Khalid, Aman
Publisher: name: Zenodo
Year: 2023

description: Galaxies are thought to evolve via a series of mergers over time. Tidal features are an important signature of recent (up to ~ 3 Gyr) mergers and offer a unique insight into the contribution of mergers to galaxy evolution. With the advent of mega surveys like the Rubin Observatory's Legacy Survey of Space and Time (LSST) it will be possible to study tidal features around billions of galaxies. To better understand the contributions of mergers to galaxy evolution it will be necessary to compare this observational data set with theoretical models. I will present my work studying the tidal features in LSST-like mock images from four cosmological simulations. In particular, how the frequency of tidal features differ between these simulations and the behaviour of this fraction with respect to stellar mass and how that differs between the simulations and existing observational studies.
Molecular dynamics simulations provide structural insight into binding of cyclic dinucleotides to human STING protein
Creators: name: Tehrani, Zahra Aliakbar
name: Rulíšek, Lubomír
name: Černý, Jiří
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Human stimulator of interferon genes (hSTING) is a signaling adaptor protein that triggers innate immune system by response to cytosolic DNA and second messenger cyclic dinucleotides (CDNs). Natural CDNs contain purine nucleobase with different phosphodiester linkage types (3′-3′, 2′-2′ or mixed 2′-3′-linkages) and exhibit different binding affinity towards hSTING, ranging from micromolar to nanomolar. High-affinity CDNs are considered as suitable candidates for treatment of chronic hepatitis B and cancer. We have used molecular dynamics simulations to investigate dynamical aspects of binding of natural CDNs (specifically, 2'-2'-cGAMP, 2'-3'-cGAMP, 3'-3'-cGAMP, 3'-3'-c-di-AMP, and 3'-3'-c-di-GMP) with hSTINGwt protein. Our results revealed that CDN/hSTINGwt interactions are controlled by the balance between fluctuations (conformational changes) in the CDN ligand and the protein dynamics. Binding of different CDNs induces different degrees of conformational/dynamics changes in hSTINGwt ligand binding cavity, especially in α1-helices, the so-called lid region and α2-tails. The ligand residence time in hSTINGwt protein pocket depends on different contribution of R232 and R238 residues interacting with oxygen atoms of phosphodiester groups in ligand, water distribution around interacting charged centers (in protein residues and ligand) and structural stability of closed conformation state of hSTINGwt protein. These findings may perhaps guide design of new compounds modulating hSTING activity. Communicated by Ramaswamy H. Sarma
In vitro and in silico analysis of Thymus serpyllum essential oil as bioactivity enhancer of antibacterial and antifungal agents
Creators: name: Salaria, Deeksha
name: Rolta, Rajan
name: Patel, Chirag N.
name: Dev, Kamal
name: Sourirajan, Anuradha
name: Kumar, Vikas
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Wild thyme (Thymus serpyllum L.) of family Laminaceae is an unexplored perennial medicinal shrub. Aerial part of this plant is traditionally used for the treatment of respiratory and gastrointestinal problems. The current study was designed to evaluate the GC-MS, antimicrobial and synergistic potential of T. serpyllum essential oil (TEO). Chemical characterization of TEO showed the presence of thymol (15.79%), Phenol, 2-(1,1-dimethylethyl) (11.55%), o-Cymene (10.96%) as major phytocompounds. Antimicrobial activity of TEO in terms zone of inhibition (ZOI) varied from 13.66 ± 0.58 mm to 33.66 ± 1.52 mm, while, thymol (10%, v/v) showed ZOI ranged from 15.5 ± 0.5 mm to 26.33 ± 2.08 mm against tested bacterial and fungal species. MIC of TEO was 0.039% to 0.078% against tested bacterial and fungal species, whereas, thymol showed 1.25% to 2.5% MIC against tested bacterial and fungal species. Different combinations of TEO (2MIC to ½MIC) and thymol (2MIC to ½MIC) with antibacterial and antifungal antibiotics (2MIC to ½MIC) were found to increase the efficacy of antibiotics by 4-130 folds against bacterial and fungal pathogens. Molecular docking showed the good binding of thymol with both bacterial and fungal targets. Whereas MD simulation showed the stability of thymol complexed with target proteins over 100 ns time scale. Thymol also fulfills the Lipinski rule and showed characteristics similar to that of drugs. Therefore, it can be concluded from the present study that TEO and its major phytocompound, thymol can act as a bioactivity enhancer of antibacterial and antifungal antibiotics and could be used as a potential candidate to fight against antimicrobial drug resistance. Communicated by Ramaswamy H. Sarma
Star-Formation and Gas Economy of Galaxies in the Deep Drilling Fields
Creators: name: , Holwerda
Publisher: name: Zenodo
Year: 2023

description: Pathfinder science in the direct detection of the atomic hydrogren (HI) of galaxies at higher redshifts (z=0.5-1.4) is currently under way for the Looking At the Distant Universe with the MeerKAT Array (LADUMA) on one of the Rubin Observatory's Deep Drilling Fields, specifically the Chandra Deep Field South. In this redshift range, the ultra-violet information on massive star-formation has shifted into the blue filters of the Rubin Observatory. The coming availability of HI line information and restframe ultraviolet star-formation estimates for galaxies over this early epoch when star-formation in the Universe started its decline since cosmic noon, offers insight in how galaxies stopped forming stars at the high rate and transitioned to the present day star formation rate. The direct link between HI gas supply and star-formation in different stellar mass bins for statistical samples of galaxies will be a tight constraint on any galaxy evolution models that explain the cosmic star-formation rates since cosmic noon 7 billion years ago. I will discuss the key role LSST u-band observations of the deep drilling fields will play here.
Estimation of respiratory pattern from video using selective ensemble aggregation
Creators: name: Prathosh, A. P.
name: Praveena, Pragathi
name: Mestha, Lalit K.
name: Bharadwaj, Sanjay
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Non-contact estimation of respiratory pattern (RP) and respiration rate (RR) has multiple applications. Existing methods for RP and RR measurement fall into one of the three categories - (i) estimation through nasal air flow measurement, (ii) estimation from video-based remote photoplethysmography, and (iii) estimation by measurement of motion induced by respiration using motion detectors. These methods, however, require specialized sensors, are computationally expensive and/or critically depend on selection of a region of interest (ROI) for processing. In this paper a general framework is described for estimating a periodic signal driving noisy LTI channels connected in parallel with unknown dynamics. The method is then applied to derive a computationally inexpensive method for estimating RP using 2D cameras that does not critically depend on ROI. Specifically, RP is estimated by imaging the changes in the reflected light caused by respiration-induced motion. Each spatial location in the field of view of the camera is modeled as a noise-corrupted linear time-invariant (LTI) measurement channel with unknown system dynamics, driven by a single generating respiratory signal. Estimation of RP is cast as a blind deconvolution problem and is solved through a method comprising subspace projection and statistical aggregation. Experiments are carried out on 31 healthy human subjects by generating multiple RPs and comparing the proposed estimates with simultaneously acquired ground truth from an impedance pneumograph device. The proposed estimator agrees well with the ground truth device in terms of correlation measures, despite variability in clothing pattern, angle of view and ROI.
Influence of non-collisional laser heating on the electron dynamics in dielectric materials
Creators: name: Barilleau, L.
name: Duchateau, G.
name: Chimier, B.
name: Geoffroy, G.
name: Tikhonchuk, V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The electron dynamics in dielectric materials induced by intense femtosecond laser pulses is theoretically addressed. The laser driven temporal evolution of the energy distribution of electrons in the conduction band is described by a kinetic Boltzmann equation. In addition to the collisional processes for energy transfer such as electron-phonon-photon and electron-electron interactions, a non-collisional process for photon absorption in the conduction band is included. It relies on direct transitions between sub-bands of the conduction band through multiphoton absorption. This mechanism is shown to significantly contribute to the laser heating of conduction electrons for large enough laser intensities. It also increases the time required for the electron distribution to reach the equilibrium state as described by the Fermi-Dirac statistics. Quantitative results are provided for quartz irradiated by a femtosecond laser pulse with a wavelength of 800 nm and for intensities in the range of tens of TW/cm$^2$, lower than the ablation threshold. The change in the energy deposition induced by this non-collisional heating process is expected to have a significant influence on the laser processing of dielectric materials.
Influence of environment on galaxy mergers
Creators: name: Pearson, William J.
Publisher: name: Zenodo
Year: 2023

description: Galaxy mergers underpin our current understanding of how galaxies grow and evolve. As the dark matter halos merge and grow, so to do the galaxies that they host. During this hierarchical growth, galaxies also join together to form groups and clusters. Clusters with high velocity dispersion are known to have more interactions but fewer mergers, as the relative velocities between galaxies are to high for the galaxies to become gravitationally bound to each other. How exactly does the environment in which a galaxy lies influence galaxy mergers and does this extend beyond the velocity dispersion? In this talk, we will discuss this question. We will examine galaxies in the North Ecliptic Pole that lie in the field, in groups and in clusters and use merging galaxies identified with deep learning. Using these galaxies, we will see how the properties of the environment influence the merger fraction. We will study how the local density, the number of galaxies in a group or cluster, the radius of the group or cluster, the velocity dispersion in a group or cluster, and group or cluster mass influence the merger fraction. For group and cluster galaxies, this will also extend these analyses to if the galaxy is a central or satellite. Why these influence the merger fraction will also be discussed. With the large area coverage and deep observations, we will see how such a study can be performed with the upcoming Rubin observations and how the larger area will be invaluable.
description: W.J.P. has been supported by the Polish National Science Center project UMO-2020/37/B/ST9/00466 and by the Foundation for Polish Science (FNP).
A study of evaporation at Lake Merrimu
Creators: name: Jackson, Peter W. .
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Additional file 1 of Improving reflective evaluations of sport through repeated experiences of fun—rationale, design, feasibility, and acceptability of the PlayFit Youth Sport Program
Creators: name: Ladwig, Matthew A.
name: Sciamanna, Christopher N.
name: Luzier, Gavin
name: Blaker, Joshua M.
name: Agans, Jennifer P.
name: Visek, Amanda J.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. CONSORT 2010 checklist of information to include when reporting a pilot or feasibility trial*.
Molecular insights into MYO3A kinase domain variants explain variability in both severity and progression of DFNB30 hearing impairment
Creators: name: Souissi, Amal
name: Driss, Dorra Abdelmalek
name: Chakchouk, Imen
name: Said, Mariem Ben
name: Ayed, Ikhlas Ben
name: Mosrati, Mohamed Ali
name: Elloumi, Ines
name: Tlili, Abdelaziz
name: Aifa, Sami
name: Masmoudi, Saber
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology
subject: Computational Biology

description: Hereditary hearing impairment (HI) is a common disease with the highest incidence among sensory defects. Several genes have been identified to affect stereocilia structure causing HI, including the unconventional myosin3A. Interestingly, we noticed that variants in MYO3A gene have been previously found to cause variable HI onset and severity. Using clinical exome sequencing, we identified a novel pathogenic variant p.(Lys50Arg) in the MYO3A kinase domain (MYO3A-KD). Previous in vitro studies supported its damaging effect as a ‘kinase-dead’ mutant. We further analyzed this variation through molecular dynamics which predicts that changes in flexibility of MYO3A structure would influence the protein-ATP binding properties. This Lys50Arg mutation segregated with congenital profound non-syndromic HI. To better investigate this variability, we collected previously identified MYO3A-KDs variants, p.(Tyr129Cys), p.(His142Gln) and p.(Pro189Thr), and built both wild type and mutant 3 D MYO3A-KD models to assess their impact on the protein structure and function. Our results suggest that KD mutations could either cause a congenital profound form of HI, when particularly affecting the kinase activity and preventing the auto-phosphorylation of the motor, or a late onset and progressive form, when partially or completely inactivating the MYO3A protein. In conclusion, we report a novel pathogenic variant affecting the ATP-binding site within the MYO3A-KD causing congenital profound HI. Through computational approaches we provide a deeper understanding on the correlation between the effects of MYO3A-KD mutations and the variable hearing phenotypes. To the best of our knowledge this is the first study to correlate mutations’ genotypes with the variable phenotypes of DFNB30. Communicated by Ramaswamy H. Sarma
Predicting epidemic evolution on contact networks from partial observations
Creators: name: Bindi, Jacopo
name: Braunstein, Alfredo
name: Dall'Asta, Luca
Publisher: name: arXiv
Year: 2016
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences
subject: 62M86

description: The massive employment of computational models in network epidemiology calls for the development of improved inference methods for epidemic forecast. For simple compartment models, such as the Susceptible-Infected-Recovered model, Belief Propagation was proved to be a reliable and efficient method to identify the origin of an observed epidemics. Here we show that the same method can be applied to predict the future evolution of an epidemic outbreak from partial observations at the early stage of the dynamics. The results obtained using Belief Propagation are compared with Monte Carlo direct sampling in the case of SIR model on random (regular and power-law) graphs for different observation methods and on an example of real-world contact network. Belief Propagation gives in general a better prediction that direct sampling, although the quality of the prediction depends on the quantity under study (e.g. marginals of individual states, epidemic size, extinction-time distribution) and on the actual number of observed nodes that are infected before the observation time.
North Saskatchewan Integrated Watershed Management Plan Development Process
Creators: North Saskatchewan Watershed Alliance (NSWA)
Publisher: name: University of Alberta Library
Year: 2012

Report includes 4 files: A Workbook To Share Your Views on Developing an Integrated Watershed Management Plan (IWMP) for the North Saskatchewan River Watershed (2011); Workbook Results: Integrated Watershed Management Plan for the North Saskatchewan River (2012)--Discussion Paper for the Development of an Integrated Watershed Management Plan for the North Saskatchewan River Watershed in Alberta (2011)--Engaging Rural Municipalities: Forum Final Report (2009); Developing Collaborative Planning Partnerships: Final Report (2010)--Integrated Watershed Management Plan for the North Saskatchewan River Watershed in Alberta, Terms of Reference (2005).
New results from the LIGHTS survey. A preview of the low surface brightness Universe to be unveiled by LSST.
Creators: name: Golini, Giulia
Publisher: name: Zenodo
Year: 2023
Subjects: galaxies: evolution – galaxies: formation – galaxies: halos – galaxies: photometry – galaxies: structure – Cosmology: dark matter

description: We present the new results of the LBT Imaging of Galaxy Haloes and Tidal Structures (LIGHTS) survey. LIGHTS is an ongoing observational campaign with the 2 × 8.4 m Large Binocular Telescope (LBT) aiming to explore the stellar haloes and the low surface brightness population of satellites down to a depth of μV ∼ 31 mag arcsec−2 (3σ in 10″ × 10″ boxes) of nearby galaxies. We simultaneously collected deep imaging in the g and r Sloan filters using the Large Binocular Cameras. The resulting images are 60 times (i.e. ∼4.5 mag) deeper than those from the Sloan Digital Sky Survey, and they have characteristics comparable (in depth and spatial resolution) to the ones expected from the future Legacy Survey of Space and Time (LSST). This depth is enough to show the structure of the stellar halos in galaxies beyond the Local Group. Additionally, we show that deep imaging from the LBT reveals low mass satellites (a few times 10^5 M⊙) with very faint central surface brightness μV(0) ∼ 27 mag arcsec−2 (i.e. similar to Local Group dwarf spheroidals, such as Andromeda XIV or Sextans, but at distances well beyond the local volume). The depth and spatial resolution provided by the LIGHTS survey open up a unique opportunity to explore the `missing satellites' problem in a large variety of galaxies beyond our Local Group down to masses where the difference between the theory and observation (if any) should be significant.
Hydrophobic quercetin encapsulated hemoglobin nanoparticles: formulation and spectroscopic characterization
Creators: name: Majumder, Debashis
name: Roychoudhry, Shaon
name: Kundu, Somashree
name: Dey, Subrata Kumar
name: Saha, Chabita
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Various natural proteins are finding application in drug delivery for their high biodegradability and biocompatibility. Albumins are well explored and now focus is shifting to other proteins like hemoglobin (Hb) with unique structural properties. In the present study Hb is allowed to denature at pH 5.0 and model hydrophobic drug quercetin (Q) is encapsulated via self-assembly and hydrophobic interactions. Fluorimetric titrations record highest binding between Hb and Q at pH 5.0, rendering significant structural changes in Hb as captured in CD spectra. A decrease in fluorescence life time of tryptophan residues from 3.31 ns in Hb to 2.89 ns in presence of Q at pH 5.0; surmises efficient binding of Q at the hydrophobic core housing tryptophan. Peak shifts in Fourier transform infrared spectroscopy spectra of Hb-Q compared to Hb evidence significant interactions between them at pH 5.0. Significant spectral changes in soret band region of Hb on addition of Q at pH 5.0 envisages unfolding of porphyrin ring and binding influence of Q. Efficient formation of Hb-Q nanoparticles (NPs) at pH 5.0 is established by DLS, SEM and TEM. Communicated by Ramaswamy H. Sarma
Additional file 1 of Barriers to tuberculosis treatment adherence in high-burden tuberculosis settings in Ashanti region, Ghana: a qualitative study from patient’s perspective
Creators: name: Appiah, Maxwell Afranie
name: Arthur, Joshua Appiah
name: Gborgblorvor, Delphine
name: Asampong, Emmanuel
name: Kye-Duodu, Gideon
name: Kamau, Edward Mberu
name: Dako-Gyeke, Phyllis
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Patient-focused interview
Exploring the dust content of Low Surface Brightness Galaxies with multi-wavelength observations
Creators: name: , Junais
name: Małek, Katarzyna
Publisher: name: Zenodo
Year: 2023

description: Although it is recognized now that low surface brightness galaxies (LSBs) contribute to a large fraction of the number density of galaxies, many of their properties are still poorly known. The upcoming Legacy Survey of Space and Time (LSST) will be particularly interesting for LSBs since they are difficult to detect with other traditional surveys. LSBs are often considered as “dust poor”, with a very low amount of dust, based on a few studies. We use, for the first time, a large sample of LSBs and high surface brightness galaxies (HSBs) with deep observational data to study the variation of stellar and dust properties as a function of the surface brightness/surface mass density. Our sample consists of 1631 galaxies that are optically selected (with ugrizy-bands) at z < 0.1 from the North Ecliptic Pole (NEP) wide field. We use the large multi-wavelength set of ancillary data in this field, ranging from UV to FIR. We measured the optical size and the surface brightness of the targets, and analyzed their spectral energy distribution using the CIGALE fitting code. Based on the measured average r-band surface brightness (mue_avg), our sample consists of 1003 LSBs (mue_avg > 23 mag/arcsec^2) and 628 HSBs (mue_avg ≤ 23 mag/arcsec^2). We found that the specific star formation rate and specific infrared luminosity (total infrared luminosity per stellar mass) remain mostly flat as a function of surface brightness for both LSBs and HSBs that are star-forming but decline steeply for the quiescent galaxies. The majority of LSBs in our sample have negligible dust attenuation (Av < 0.1 mag), except for about 4% of them that show significant attenuation with a mean Av of 0.8 mag. We found that these LSBs with a significant attenuation also have a high r-band mass-to-light ratio (M/Lr > 3 Msun/Lsun), making them outliers from the linear relation of surface brightness and stellar mass surface density. These outlier LSBs also show similarity to the extreme giant LSBs from the literature, indicating a possibly higher dust attenuation in giant LSBs as well. This work provides a large catalog of LSBs and HSBs with detailed measurements of their several optical and infrared physical properties. Our results suggest that the dust content of LSBs is more varied than previously thought, with some of them having significant attenuation making them fainter than their intrinsic value. With these results, we will be able to make predictions on the dust content of the population of LSBs and how the presence of dust will affect their observations from current/upcoming surveys like JWST and LSST.
The composition of condensates from the evaporation of magnefite spent liquor
Creators: name: Llewellyn, Paul .
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Azoles containing naphthalene with activity against Gram-positive bacteria: in vitro studies and in silico predictions for flavohemoglobin inhibition
Creators: name: Sari, Suat
name: Sabuncuoğlu, Suna
name: Aslan, Ebru Koçak
name: Avci, Ahmet
name: Kart, Didem
name: Özdemir, Zeynep
name: Acar, M. Fahir
name: Sayoğlu, Burcu
name: Alagöz, M. Abdullah
name: Karakurt, Arzu
name: Dalkara, Sevim
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Azoles are first-line drugs used in fungal infections. Topical antifungals, such as miconazole and econazole, are known to be active against Gram-positive bacteria, which was reported to result from bacterial flavohemoglobin (flavoHb) inhibition. Dual antibacterial/antifungal action is believed to have benefits for antimicrobial chemotherapy. In this study, we tested antibacterial effects of an in-house library of naphthalene-bearing azoles, some of which were reported as potent antifungals, in an attempt to find dual-acting hits. Several potent derivatives were obtained against the Gram-positive bacteria, Enterococcus faecalis and Staphylococcus aureus. 9 was active at a minimum inhibitor concentration (MIC) less than 1 µg/ml against E. faecalis and S. aureus, and 10 against S. aureus. 16 was also potent against E. faecalis and S. aureus (MIC = 1 and 2 µg/ml, respectively). Six more were active against S. aureus with MIC ≤ 4 µg/ml. In vitro cytotoxicity studies showed that the active compounds were safe for healthy cells within their MIC ranges. According to the calculated descriptors, the library was found within the drug-like chemical space and free of pan-assay interference compounds (PAINS). Molecular docking studies suggested that the compounds might be bacterial flavohemoglobin (flavoHb) inhibitors and the azole and naphthalene rings were important pharmacophores, which was further supported by pharmacophore modeling study. As a result, the current study presents several non-toxic azole derivatives with antibacterial effects. In addition to their previously reported antifungal properties, they could set a promising starting point for the future design of dual acting antimicrobials. Communicated by Ramaswamy H. Sarma
Efficient implementation of RKN-type Fourier collocation methods for second-order differential equations
Creators: name: Wang, Bin
name: Meng, Fanwei
name: Fang, Yonglei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper we discuss the efficient implementation of RKN-type Fourier collocation methods, which are used when solving second-order differential equations. The proposed implementation relies on an alternative formulation of the methods and the blended formulation. The features and effectiveness of the implementation are confirmed by the performance of the methods on two numerical tests.
Additional file 2 of Barriers to tuberculosis treatment adherence in high-burden tuberculosis settings in Ashanti region, Ghana: a qualitative study from patient’s perspective
Creators: name: Appiah, Maxwell Afranie
name: Arthur, Joshua Appiah
name: Gborgblorvor, Delphine
name: Asampong, Emmanuel
name: Kye-Duodu, Gideon
name: Kamau, Edward Mberu
name: Dako-Gyeke, Phyllis
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Characteristics of study participants
Top-N Recommendation on Graphs
Creators: name: Kang, Zhao
name: Peng, Chong
name: Yang, Ming
name: Cheng, Qiang
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Retrieval (cs.IR)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Recommender systems play an increasingly important role in online applications to help users find what they need or prefer. Collaborative filtering algorithms that generate predictions by analyzing the user-item rating matrix perform poorly when the matrix is sparse. To alleviate this problem, this paper proposes a simple recommendation algorithm that fully exploits the similarity information among users and items and intrinsic structural information of the user-item matrix. The proposed method constructs a new representation which preserves affinity and structure information in the user-item rating matrix and then performs recommendation task. To capture proximity information about users and items, two graphs are constructed. Manifold learning idea is used to constrain the new representation to be smooth on these graphs, so as to enforce users and item proximities. Our model is formulated as a convex optimization problem, for which we need to solve the well-known Sylvester equation only. We carry out extensive empirical evaluations on six benchmark datasets to show the effectiveness of this approach.
description: CIKM 2016
Readability of Philippine Literature in English in Commercially Published English Textbooks
Creators: name: Sarmiento-Labastilla, Leah Blescila V.
Publisher: name: Zenodo
Year: 2014
Subjects: Education
Philippine Literature
English textbooks
Readability studies

description: Abstract Readability studies in the United States have a long history spanning over 70 years, but here in the Philippines, these studies are rare. Readability studies are important in the evaluation of texts to match the readers and their textbooks so that communicative competencies will be developed. This study explored the readability of nine (9) Philippine short stories written in English that are featured in commercially published Grade 7 English textbooks. Three (3) readability indices were used to describe the level of text difficulty.: Flesh-Kincaid Grade Level, Cloze Test, and Readability Checklist. The texts were tested for the Flesch-Kincaid Grade Level through online readability calculators. The same texts were converted into cloze tests and were given to 75 Grade Six students of one (1) private and one (1) public school in a first-class urban municipality outside of the National Capital Region. Three (3) Grade 7 English teachers and 20 Grade 8 students evaluated the difficulty level using the readability checklist. Results show that the short stories chosen for Grade 7 English textbooks are much too difficult for the students in that level. The short stories have varied levels of text difficulty, from 3.0 to 10.0 Flesch-Kincaid Grade levels, which reveal the absence of any leveling standards in choosing the literary pieces included in Grade 7 English textbooks. Based on the readability checklists done by both teachers and Grade 8 students, the stories were of high quality in terms of literary merit. However, the cloze scores show that these stories are frustrating for the Grade 7 students, which means the students do not yet have the linguistic abilities require to understand the text, and teachers will require more effort in helping students to understand the text.
description: Masters Thesis
Heat transfer characteristics for 60 degree stabiliser cooling pads
Creators: name: Westmoreland, Ricky Alan.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies
Creators: name: Snoussi, Mejdi
name: Redissi, Alaeddine
name: Mosbah, Amor
name: De Feo, Vincenzo
name: Adnan, Mohd
name: Aouadi, Kaïss
name: Alreshidi, Mousa
name: Patel, Mitesh
name: Kadri, Adel
name: Noumi, Emira
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The main objective of this study is to find out the anti-SARS-CoV-2 potential of emetine by using molecular docking and dynamic simulation approaches. Interestingly, molecular docking studies suggest that Emetine showed significant binding affinity toward Nsp15 (-10.8 kcal/mol) followed by Nsp12 (-9.5 kcal/mol), RNA-dependent RNA polymerase, RdRp (-9.5 kcal/mol), Nsp16 (-9.4 kcal/mol), Nsp10 (-9.2 kcal/mol), Papain-like protein (-9.0 kcal/mol), Nsp13 (-9.0 kcal/mol), Nsp14 (-8.9 kcal/mol) and Spike Protein Receptor Domain (-8.8 kcal/mol) and chymotrypsin-like protease, 3CLpro (-8.5 kcal/mol), respectively, which are essential for viral infection and replication. In addition, molecular dynamic simulation (MD) was also performed for 140 ns to explore the stability behavior of the main targets and inhibitor complexes as well as the binding mechanics of the ligand to the target proteins. The obtained MD results followed by absolute binding energy calculation confirm that the binding of emetine at the level of the various receptors is more stable. The complex EmetineNSP15, mechanistically was stabilized as follows: Emetine first binds to the monomer, after, binds to the second inducing the formation of a dimer which in turn leading to the formation of complex that simulation stabilizes it at a value less than 5 Å. Overall, supported by the powerful and good pharmacokinetic data of Emetine, our findings with clinical trials may be helpful to confirm that Emetine could be promoted in the prevention and eradication of COVID-19 by reducing the severity in the infected persons and therefore can open possible new strategies for drug repositioning. Communicated by Ramaswamy H. Sarma
In silico analysis of glycosylation pattern in 5th-6th repeat sequence of reelin glycoprotein
Creators: name: Demir, Ramiz
name: Deveci, Remziye
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Reelin is an extracellular matrix glycoprotein that plays a key role in cortical development, maturation, synaptic plasticity, and memory formation in the adult mammalian brain. Glycosylation is a significant post- and co-translational modification of proteins. Although glycosylation contributes to the characteristic of proteins from their production to molecular interactions, the knowledge about the glycosylation pattern of reelin is very limited. In this study, we aimed to predict the potential glycosylation pattern of the 5th-6th repeat of central reelin fragment that responsible for their signaling, by using in silico methods. We found that the predicted glycosylation pattern of the 5th-6th repeat of human reelin was highly conserved between vertebrate species. However, this conservation was not observed in analyzed invertebrates. For the first time, we described the sites of glycosylation at a three-dimensional protein structure in human reelin. Because the sites were very closed to EGF-like repeats and receptor binding sites, they could contribute the interaction with a partner of reelin in addition to the effect of thermostability to protein. Many of the residues related glycosylation were also conserved in analyzed species. These findings may guide biochemical, genetic, and glycobiology base on further experiments about reelin glycosylation. The understanding of reelin glycosylation might change the point of view of treatment for many pathological conditions in neurodegenerative diseases such as Alzheimer’s disease. Communicated by Ramaswamy H. Sarma
Study of optical nonlinearity of a highly dispersive medium using optical heterodyne detection technique
Creators: name: Bhowmick, Arup
name: Sahoo, Sushree S.
name: Mohapatra, Ashok K
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss the optical heterodyne detection technique to study the absorption and dispersion of a probe beam propagating through a medium with a narrow resonance. The technique has been demonstrated for Rydberg Electro-magnetically induced transparency (EIT) in rubidium thermal vapor and the optical non-linearity of a probe beam with variable intensity has been studied. A quantitative comparison of the experimental result with a suitable theoretical model is presented. The limitations and the working regime of the technique are discussed.
An analysis of static stresses using the boundary element method
Creators: name: McAree, Peter Ross.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The lifetime of the $B_c^-$ meson and the anomalies in $B\to D^{(*)}τν$
Creators: name: Alonso, Rodrigo
name: Grinstein, Benjamín
name: Camalich, Jorge Martin
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We investigate a new constraint on new-physics interpretations of the anomalies observed in $B\to D^{(*)}τν$ decays making use of the lifetime of the $B_c^-$ meson. A constraint is obtained by demanding that the rate for $B_c^-\toτ^-\barν$ does not exceed the fraction of the total width that is allowed by the calculation of the lifetime in the standard model. This leads to a very strong bound on new-physics scenarios involving scalar operators since they lift the slight, but not negligible, chiral suppression of the $B_c^-\toτ^-\barν$ amplitude in the standard model. The new constraint renders a scalar interpretation of the enhancement measured in $R_{D^*}$ implausible, including explanations implementing extra Higgs doublets or certain classes of leptoquarks. We also discuss the complementarity of $R_{D^{(*)}}$ and a measurement of the longitudinal polarization of the $τ$ in the $B\to D^*τν$ decay in light of our findings.
description: 6 pages, 2 figs
Additional file 3 of Barriers to tuberculosis treatment adherence in high-burden tuberculosis settings in Ashanti region, Ghana: a qualitative study from patient’s perspective
Creators: name: Appiah, Maxwell Afranie
name: Arthur, Joshua Appiah
name: Gborgblorvor, Delphine
name: Asampong, Emmanuel
name: Kye-Duodu, Gideon
name: Kamau, Edward Mberu
name: Dako-Gyeke, Phyllis
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Code patterns