Hepatitis B Virus Dataset from the National Institute for Health Research Health Informatics Collaborative (NIHR HIC): Describing the characteristics of infection and therapy to inform translational research
Creators: name: Tingyan Wang
name: Smith, David A
name: Campbell, Cori
name: Freeman, Oliver
name: Moysova, Zuzana
name: Noble, Theresa
name: Várnai, Kinga A
name: Harris, Steve
name: Hizni Salih
name: Roadknight, Gail
name: Little, Stephanie
name: Glampson, Ben
name: Mercuri, Luca
name: Papadimitriou, Dimitri
name: Jones, Christopher R
name: Taylor, Vince
name: Chaudhry, Afzal
name: Phan, Hang
name: Borca, Florina
name: Olza, Josune
name: Warricker, Frazer
name: Romão, Luis
name: Ramlakhan, David
name: English, Louise
name: Nastouli, Eleni
name: Khakoo, Salim I
name: Gelson, William
name: Cooke, Graham S
name: Woods, Kerrie
name: Davies, Jim
name: Matthews, Philippa C
name: Barnes, Eleanor
Publisher: name: F1000 Research Limited
Year: 2021

description: <b><i>* Full information of affiliations for all authors is included in the poster, noting that only institutions of corresponding authors are allowed to display above on this page.</i><br> <br> Background: </b>Most UK data related to HBV have been reported from certain populations, e.g., HIV/HBV coinfected individuals, blood/organ donors, or primary care population. We aim to characterise HBV infection across multi-site secondary care in the UK, providing data to support international goals for viral hepatitis elimination.<br> <br> <b>Methods: </b>We used a clinical informatics infrastructure, supported by NIHR Health Informatics Collaborative (HIC), to collect individual-level data from electronic patient record (EPR) systems in five NHS Trusts. Index date was defined as the first recorded positive HBsAg or HBV DNA.<br> <br> <b>Results: </b>We identified 4259 adults with chronic HBV infection between 1994 - 2020. 54% were male, and the median age was 39 years (interquartile range [IQR]: 32-48) at the index date, with diverse ethnicities (31% Asian, 24% Black, 30% White, and 15% Other). The median follow-up duration was 4.8 years (IQR: 2.8-7.1), with ~7 deaths per 1,000 person-years. At the index date, 21% had high viraemia levels (≥20,000 IU/ml), and 24% had elevated ALT (above the upper limit of normal), respectively. Antiviral therapy was prescribed in 12%, and those treated were more likely to be male, significantly older at index date, and more likely to be Asian than from other ethnic groups (all p-values &lt;0.001).<br> <br> <b>Discussion: </b>This novel dataset provides comprehensive longitudinal data on HBV infection from multi-site secondary care in the UK, offering important opportunities for HBV translational research. We have successfully integrated data from heterogenous EPR environments. Longitudinal data collection is continuing, and we are extending collaboration to more NHS Trusts.<br> <br> <i><b>Ethics approval</b>: The research database for the NIHR HIC viral hepatitis theme was approved by South Central - Oxford C Research Ethics Committee (REF Number: 21/SC/0060). All methods in this study were carried out in accordance with relevant guidelines and regulations.</i><br> <br> <i><b>Funding</b>: This work has been conducted using National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) data resources and funded by the NIHR HIC, and has been supported by NIHR Biomedical Research Centres at Cambridge, Imperial, Oxford, Southampton, and University College London Hospitals. GSC is an NIHR research professor, EB is an NIHR senior investigator. PCM is funded by the Wellcome Trust (ref. 110110/Z/15/Z) and holds an NIHR Senior Fellowship award. CC is a doctoral student who receives partial doctoral funding from GlaxoSmithKline (GSK). FW is an NIHR funded ACF. The views expressed in this article are those of the authors and not necessarily those of the National Health Service, the NIHR, or the Department of Health.<br> <br> <b>Acknowledgments</b>: The authors would like to thank all the research nurses and research admin staff at the contributing sites for their help in data collection and submission. The authors would also like to thank clinicians, projects managers, informaticians, and data managers at the other participating sites (Nottingham University Hospitals NHS Trust; Manchester University NHS Foundation Trust; Liverpool University Hospitals NHS Foundation Trust; University Hospitals Birmingham NHS Foundation Trust; King's College Hospital NHS Foundation Trust) working to submit data.<br> <br> <b>Data availability statement</b>: Further details are available at https://hic.nihr.ac.uk. Queries regarding data access should be directed to orh-tr.nihrhic@nhs.net.</i>