cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MOESM3 of Comparing 16S rDNA amplicon sequencing and hybridization capture for pea aphid microbiota diversity analysis
Creators: name: Cariou, Marie
name: Ribière, Céline
name: Morlière, Stéphanie
name: Gauthier, Jean-Pierre
name: Jean-Christophe Simon
name: Peyret, Pierre
name: Charlat, Sylvain
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Additional file 3: Table S2. Normalized and relative abundances of the different OTUs.
Symplectic invariants for parabolic orbits and cusp singularities of integrable systems with two degrees of freedom
Creators: name: Bolsinov, Alexey
name: Guglielmi, Lorenzo
name: Kudryavtseva, Elena
Publisher: name: arXiv
Year: 2018
Subjects: subject: Symplectic Geometry (math.SG)
subject: Differential Geometry (math.DG)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 53D12, 53D20, 37J35, 70H06

description: We discuss normal forms and symplectic invariants of parabolic orbits and cuspidal tori in integrable Hamiltonian systems with two degrees of freedom. Such singularities appear in many integrable systems in geometry and mathematical physics and can be considered as the simplest example of degenerate singularities. We also suggest some new techniques which apparently can be used for studying symplectic invariants of degenerate singularities of more general type.
description: 3 figures
Thermal Hadron Production in High Energy Heavy Ion Collisions
Creators: name: Cleymans, Jean
name: Satz, Helmut
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We provide a method to test if hadrons produced in high energy heavy ion collisions were emitted at freeze-out from an equilibrium hadron gas. Our considerations are based on an ideal gas at fixed temperature $T_f$, baryon number density $n_B$, and vanishing total strangeness. The constituents of this gas are all hadron resonances up to a mass of 2 GeV; they are taken to decay according to the experimentally observed branching ratios. The ratios of the various resulting hadron production rates are tabulated as functions of $T_f$ and $n_B$. These tables can be used for the equilibration analysis of any heavy ion data; we illustrate this for some specific cases.
description: 12 pages (not included :13 figures + tables) report CERN-TH 6523/92 and Bielefeld preprint BI-TP 92/08
Making Public Pasts: Cultural Dialogue and Negotiation in Public Space
Creators: name: Rodrigo, Russell
Publisher: name: Landscape Review
Year: 2015

description: In The Collective Memory, Maurice Halbwachs (1950/1980) asserts there is a close relationship between memory and space, in that memory is not just a matter of consciously lived time but of socially lived space and the collective representation of that space. The city, for Halbwachs, is an image of collective memory. Relationships between individuals and between groups are established with regard to the artefacts of the city. Collective memory could not be maintained and passed on from one generation to the next were it not able to reside in physical objects of remembrance such as spaces of public commemoration. This paper examines the way in which public spaces of commemoration shape a consensual view of the past through the mediation of complex political, personal, cultural and aesthetic forces.
description: Landscape Review, Vol 15 No 2 (2015): Commemoration and Public Space
Many-Body effects and resonances in universal quantum sticking of cold atoms to surfaces
Creators: name: Bittner, Eric R.
name: Light, John C.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The role of shape resonances and many-body effects on universal quantum sticking of ultra cold atoms onto solid surfaces is examined analytically and computationally using an exactly solvable representation of the Dyson equation. We derive the self-energy renormalization of the the transition amplitude between an ultra cold scattering atom and the bound states on the surface in order to elucidate the role of virtual phonon exchanges in the limiting behavior of the sticking probability. We demonstrate that, to first order in the interactions for finite ranged atom-surface potentials, virtual phonons can only rescale the strength of the atom-surface coupling and do not rescale the range of the coupling. Thus, universal sticking behaviour at ultra-low energies is to be expected for all finite ranged potentials. We demonstrate that the onset of the universal sticking behavior depends greatly on the position of the shape resonance of the renormalized potential and for sufficiently low energy shape resonances, deviations from the universal $s(E)\propto\sqrt{E}$ can occur near these energies. We believe that this accounts for many of the low energy sticking trends observed in the scattering of sub-millikelvin H atoms from superfluid $^4$He films.
description: To appear in 08-Feb-95 issue of The Journal of Chemical Physics
Squeezed Thermal Vacuum and the Maximum Scale for Inflation
Creators: name: Gasperini, M.
name: Giovannini, M.
name: Veneziano, G.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the stimulated emission of gravitons from an initial state of thermal equilibrium, under the action of the cosmic gravitational background field. We find that the low-energy graviton spectrum is enhanced if compared with spontaneous creation from the vacuum; as a consequence, the scale of inflation must be lowered, in order not to exceed the observed CMB quadrupole anisotropy. This effect is particularly important for models based on a symmetry-breaking transition which require, as initial condition, a state of thermal equilibrium at temperatures of the order of the inflation scale.
description: 13 pages, plain tex, three figures available upon request, to appear in Phys.Rev.D, CERN-TH.6836/93
What $e^+e^-$ collider could make a ``no-lose'' search for MSSM Higgs bosons?
Creators: name: Barger, V.
name: Cheung, Kingman
name: Phillips, R. J. N.
name: Stange, A. L.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The lightest CP-even Higgs boson $h$ in the minimum supersymmetric standard model (MSSM) has a mass upper bound depending on the top quark and squark masses. An $e^+e^-$ collider with enough energy and luminosity to produce $h+Z$ at measurable rates up to the maximum $h$ mass would cover the entire MSSM parameter space, if $h+A$ production was also searched for. We explore the energy and/or luminosity needed for various top quark and squark masses. For $m_t=150$\,GeV and 1\,TeV SUSY mass scale, a 230\,GeV collider with 10\,fb$^{-1}$ luminosity would suffice.
description: MAD/PH/704 11 pages, plus 2 postscript figures available on request
National Identity and Commemorative Space: Connections to the Nation through Time and Site
Creators: name: Sumartojo, Shanti
Publisher: name: Landscape Review
Year: 2015

description: Historical monuments and memorials often mobilise national history to serve contemporary political ends through the people and events they memorialise. They can also be powerful agents of erasure or forgetting, as some histories are privileged over others. This article addresses how national identity works through and on public commemorative structures and how aspects of such structures and their landscapes might reflect back on to national identity. This includes the role that aesthetic forms and designed spaces play in the representation and performance of such identities through the use of space. This paper makes three overlapping arguments about the relationship between national identity, commemoration and public space. The first is that spatial context shapes discursive meaning. Second, ways of understanding time in national commemorative places are used to connect individuals to the nation and to co-nationals in the past, present and future; even so, site histories can complicate these narratives. Third, official and vernacular uses of commemorative sites activatelandscapes in ways that both reinforce and undermine each other. These arguments are underpinned by examples from Australian and British commemorative sites, with a focus on how they are employed by their users to define or promulgate national identity.
description: Landscape Review, Vol 15 No 2 (2015): Commemoration and Public Space
Growth of perturbations in dark energy parametrization scenarios
Creators: name: Mehrabi, A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this paper, we study the evolution of dark matter perturbations in the linear regime by considering the possibility of dark energy perturbations. To do this, two popular parameterizations, CPL and BA with same number of free parameters and different redshift dependency have been considered. We integrate the full relativistic equations to obtain the growth of matter fluctuations for both clustering and smooth versions of CPL and BA dark energy. The growth rate is larger (smaller) than the $Λ$CDM in the smooth cases when $w-1$) but the dark energy clustering gives a larger (smaller) growth index when $w>-1$ ($w
description: Accepted for publication in PRD
Additional file 2: of Do adolescents understand the items of the European Health Literacy Survey Questionnaire (HLS-EU-Q47) – German version? Findings from cognitive interviews of the project “Measurement of Health Literacy Among Adolescents” (MOHLAA) in Germany
Creators: name: Domanska, Olga
name: Firnges, Christiane
name: Bollweg, Torsten
name: Sørensen, Kristine
name: Holmberg, Christine
name: Jordan, Susanne
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: Table S2. Characteristics of the participants of cognitive interviews in the MOHLAA study in Germany (12/2015–03/2016). (DOCX 45 kb)
A novel connection between scalar field theories and quantum mechanics
Creators: name: Bazeia, D.
name: Losano, L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: This work deals with scalar field theories and supersymmetric quantum mechanics. The investigation is inspired by a recent result, which shows how to use the reconstruction mechanism to describe two distinct field theories from the very same quantum mechanics potential, and by an older work, which describes the deformation procedure that offers an interesting way to generate and solve new scalar field theories, starting from a given model of current interest. We use the procedure to unveil a new route, from which one can describe families of scalar field theories that engender the very same quantum mechanics potential. The approach can be applied algorithmically, and implemented to generate models that give rise to distinct quantum mechanics systems as well.
description: 5 pages, 9 figures. To appear in EPL
title: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 73
Creators: name: Aubert, Eduardo Henrik
name: Brochard, Pierre
name: Aubert, Eduardo Henrik
name: Brochard, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Laboratoire de médiévistique occidentale de Paris
subject: Semur-en-Auxois
subject: LaMOP

description: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 73

production-software: eScriptorium + Kraken version 3.0.13 (PageXml)
description: Source: https://www.nakala.fr/10.34847/nkl.ee2926zv
description: Source: https://www.nakala.fr/10.34847/nkl.e905tdea
description: Relation: https://lamop.hypotheses.org/
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
Additional file 1: of Improving cardiovascular health and quality of life in people with severe mental illness: study protocol for a randomised controlled trial
Creators: name: Battersby, Malcolm
name: Kidd, Michael
name: Licinio, Julio
name: Aylward, Philip
name: Baker, Amanda
name: Ratcliffe, Julie
name: Quinn, Stephen
name: Castle, David
name: Zabeen, Sara
name: A. Fairweather-Schmidt
name: Lawn, Sharon
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Developmental Biology
Science Policy

description: SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*. (DOC 125 kb)
Uncovering allostery and regulation in SORCIN through molecular dynamics simulations
Creators: name: Saravanan, Vinnarasi
name: Ahammed, Ijas
name: Bhattacharya, Akash
name: Bhattacharya, Swati
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Soluble resistance-related calcium-binding protein or Sorcin is an allosteric, calcium-binding Penta-EF hand (PEF) family protein implicated in multi-drug resistant cancers. Sorcin is known to bind chemotherapeutic molecules such as Doxorubicin. This study uses in-silico molecular dynamics simulations to explore the dynamics and allosteric behavior of Sorcin in the context of Ca2+ uptake and Doxorubicin binding. The results show that Ca2+ binding induces large, but reversible conformational changes in the Sorcin structure which manifest as rigid body reorientations that preserve the local secondary structure. A reciprocal allosteric handshake centered around the EF5 hand is found to be key in Sorcin dimer formation and stabilization. Binding of Doxorubicin results in rearrangement of allosteric communities which disrupts long-range allosteric information transfer from the N-terminal domain to the middle lobe. However, this binding does not result in secondary structure destabilization. Sorcin does not appear to have a distinct Ca2+ activated mode of Doxorubicin binding. Communicated by Ramaswamy H. Sarma
Topology, Decoherence, and Semiclassical Gravity
Creators: name: Kiefer, C.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We address the issue of recovering the time-dependent Schrödinger equation from quantum gravity in a natural way. To reach this aim it is necessary to understand the nonoccurrence of certain superpositions in quantum gravity. We explore various possible explanations and their relation. These are the delocalisation of interference terms through interaction with irrelevant degrees of freedom (decoherence), gravitational anomalies, and the possibility of $θ$ states. The discussion is carried out in both the geometrodynamical and connection representation of canonical quantum gravity.
description: 18 pages, ZU-TH 3/93, to appear in Phys. Rev. D
Nonet Symmetry and Two-Body Decays of Charmed Mesons
Creators: name: Kwong, Waikwok
name: Rosen, S. P.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The decay of charmed mesons into pseudoscalar (P) and vector (V) mesons is studied in the context of nonet symmetry. We have found that it is badly broken in the PP channels and in the P sector of the PV channels as expected from the non-ideal mixing of the ηand the η'. In the VV channels, it is also found that nonet symmetry does not describe the data well. We have found that this discrepancy cannot be attributed entirely to SU(3) breaking at the usual level of 20--30%. At least one, or both, of nonet and SU(3) symmetry must be very badly broken. The possibility of resolving the problem in the future is also discussed.
description: 9 pages, UTAPHY-HEP-3
Low-temperature dynamical simulation of spin-boson systems
Creators: name: Egger, Reinhold
name: Mak, C. H.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The dynamics of spin-boson systems at very low temperatures has been studied using a real-time path-integral simulation technique which combines a stochastic Monte Carlo sampling over the quantum fluctuations with an exact treatment of the quasiclassical degrees of freedoms. To a large degree, this special technique circumvents the dynamical sign problem and allows the dynamics to be studied directly up to long real times in a numerically exact manner. This method has been applied to two important problems: (1) crossover from nonadiabatic to adiabatic behavior in electron transfer reactions, (2) the zero-temperature dynamics in the antiferromagnetic Kondo region 1/2
description: Phys. Rev. B (in press), 28 pages, 6 figures
Supersymmetric Homogeneous Quantum Cosmologies Coupled to a Scalar Field
Creators: name: Bene, J.
name: Graham, R.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Recent work on $N=2$ supersymmetric Bianchi type IX cosmologies coupled to a scalar field is extended to a general treatment of homogeneous quantum cosmologies with explicitely solvable momentum constraints, i.e. Bianchi types I, II, VII, VIII besides the Bianchi type IX, and special cases, namely the Friedmann universes, the Kantowski-Sachs space, and Taub-NUT space. Besides the earlier explicit solution of the Wheeler DeWitt equation for Bianchi type IX, describing a virtual wormhole fluctuation, an additional explicit solution is given and identified with the `no-boundary state'.
description: 23 PAGES
Identification of terpenoids as dihydropteroate synthase and dihydrofolate reductase inhibitors through structure-based virtual screening and molecular dynamic simulations
Creators: name: Saini, Abhishek
name: Kumar, Amit
name: Jangid, Kailash
name: Kumar, Vinod
name: Jaitak, Vikas
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Bacterial infections are rising, and antimicrobial resistance (AMR) in bacteria has worsened the scenario, requiring extensive research to find alternative therapeutic agents. Terpenoids play an essential role in protecting plants from herbivores and pathogens. The present study was designed to focus on in silico evaluation of terpenoids for their affinity towards two necessary enzymes, i.e. DHFR and DHPS, which are involved in forming 5, 6, 7, 8-tetrahydrofolate, a key component in bacterial DNA synthesis proteins. Additionally, to account for activity against resistant bacteria, their affinity towards the L28R mutant of DHFR was also assessed in the study. The structure-based drug design approach was used to screen the compound library of terpenes for their interaction with active sites of DHFR and DHPS. Further, compounds were screened based on their dock score, pharmacokinetic properties, and binding affinities. A total of five compounds for each target protein were screened, having dock scores better than their respective standard drug molecules. CNP0169378 (−8.4 kcal/mol) and CNP0309455 (−6.5 kcal/mol) have been identified as molecules with a higher affinity toward the targets of DHFR and DHPS, respectively. At the same time, one molecule CNP0298407 (−5.8 kcal/mol for DHPS, −7.6 kcal/mol for DHFR, −6.1 kcal/mol for the L28R variant), has affinity for both proteins (6XG5 and 6XG4). All the molecules have good pharmacokinetic properties. We further validated the docking study by binding free energy calculations using the MM/GBSA approach and molecular dynamics simulations. Communicated by Ramaswamy H. Sarma
Urban Landscape: Interstitial Spaces
Creators: name: Sousa Matos, Rute
Publisher: name: Landscape Review
Year: 2014

description: Any analysis of urban development will certainly show that the city has undergone numerous transformations, not only from conceptual and ideological perspectives but also in morphologic terms determined by different cultural and social contexts. This does not constitute in itself a negative factor; it is simply a distinct reality, determined by the rhythms of technological, economic, social and demographic changes. The extensive growth of urbanisation has raised new questions about the diversity of the urban interstitial void spaces, mainly because of their apparent inability to appropriate a recognisable typology or their lack of an attributed name. In the last decades, the open space, usually called ‘green’ space, has played a subordinate role in the construction of the urban space. The indifference to its qualitative definition tends to reduce these spaces to just another index. Together with high and persistent deficits of environmental infrastructures, there came new attempts to understand the urban condition of the interstitial void spaces and the value of landscape quality. All things considered, it is imperative to proceed to an appropriate and intentional reconstruction of these spaces as a vital condition for its defence, which can be guaranteed by understanding and utilising it.
description: Landscape Review, Vol 13 No 1 (2009): Globalisation in Landscape Architecture
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00601
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00601, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
High-Dimensional Vector Semantics
Creators: name: Andrecut, M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: In this paper we explore the "vector semantics" problem from the perspective of "almost orthogonal" property of high-dimensional random vectors. We show that this intriguing property can be used to "memorize" random vectors by simply adding them, and we provide an efficient probabilistic solution to the set membership problem. Also, we discuss several applications to word context vector embeddings, document sentences similarity, and spam filtering.
description: 12 pages, 5 figures, Int. J. Mod. Phys. C, 2018
Elucidation of bezlotoxumab binding specificity to toxin B in Clostridioides difficile
Creators: name: Karnchanapandh, Kun
name: Hanpaibool, Chonnikan
name: Sanachai, Kamonpan
name: Rungrotmongkol, Thanyada
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: C. difficile or Clostridioides difficile infection (CDI) is currently one of the major causes of epidemics worldwide. Toxin B from Clostridioides difficile toxin B (TcdB) infection is the main target protein inhibiting CDI recurrence. Clinical research suggested that bezlotoxumab’s (Bez) efficiency is significantly reduced in neutralizing the B2 strain compared to the B1 strain. The monoclonal antibody (mAb) functions by binding to the epitope 1 and 2 regions in the combined repetitive oligopeptide (CROP) domain. Some binding residues are distinctively different between B1 and B2 strains. In this work, we aimed to elucidate and compare insights into the interaction of toxins B1 and B2 in complex with Bez by using all-atom molecular dynamics (MD) simulations and binding free energy calculations. The predicted ΔGbinding values suggested that the antibody (Ab) could bind to toxin B1 significantly better than B2, supported by higher salt bridge and hydrogen bonding (H-bonding) interactions, as well as the number of contact residues between the two focused proteins. The toxin B1 residues important for binding with Bez were E1878, T1901, E1902, F1905, N1941, V1946, N2031, T2032, E2033, V2076, V2077, and E2092. The lower susceptibility of Bez towards toxin B2 was primarily due to a change of residue E2033 from glutamate to alanine (A2033) and the loss of E1878 and E1902 contributions, as determined by the intermolecular interaction changes from the dynamic residue interaction network (dRIN) analysis. The obtained data strengthen our understanding of Bez/toxin B binding. Communicated by Ramaswamy H. Sarma
Canonical Quantum Supergravity in Three Dimensions, (some lines lost during submission)
Creators: name: Matschull, H. -J.
name: Nicolai, H.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the canonical treatment and quantization of matter coupled supergravity in three dimensions, with special emphasis on $N=2$ supergravity. We then analyze the quantum constraint algebra; certain operator ordering ambiguities are found to be absent due to local supersymmetry. We show that the supersymmetry constraints can be partially solved by a functional analog of the method of characteristics. We also consider extensions of Wilson loop integrals of the type previously found in ordinary gravity, but now with connections involving the bosonic and fermionic matter fields in addition to the gravitational connection. In a separate section of this paper, the canonical treatment and quantization of non-linear coset space sigma models are discussed in a self contained way.
description: 40 pages, LaTeX, DESY 93-073
Pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation for identification of potential ERK inhibitors
Creators: name: Tian, Yafeng
name: Zhang, Mi
name: Heng, Panpan
name: Hou, Hua
name: Wang, Baoshan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Computational Biology

description: As the downstream component of the mitogen-activated protein kinases (MAPK) pathway, the extracellular signal-regulated kinase (ERK) is responsible for phosphorylating a broad range of substrates in cell proliferation, differentiation, and survival. Direct targeting the ERK proteins by the piperidinopyrimidine urea-based inhibitors has been demonstrated to be an effective way to block the MAPK signaling pathway in inhibiting tumor growth. In order to discover better inhibitors, a computer-aided drug design (CADD) approach was employed to reveal the pharmacological characteristics and mechanisms of action. The pharmacophore model was generated on the basis of the compounds with eight features, i.e., four hydrogen bond acceptor atoms, one hydrogen bond donor atom, and three hydrophobic centers. A total of 14 hit compounds were obtained through virtual screening. Two potential inhibitors, namely VS01 and VS02, have been identified by molecular docking and molecular dynamics simulations. Both compounds are capable of attaching to the ERK pocket precisely. The binding free energies of VS01 and VS02 are about 15 kJ/mol and 4 kJ/mol stronger than that of the clinic Ulixertinib because of the characteristic hydrogen bonding, electrostatic, and hydrophilic interactions. The present theoretical investigations shed new light on the rational design of the potential ERK inhibitors to stimulate further experimental tests. Communicated by Ramaswamy H. Sarma
The Value of Landscape Essence
Creators: name: Da Conceição Marques Freire, Maria
Publisher: name: Landscape Review
Year: 2014

description: A new approach to interpreting the landscape is examined by accepting its complexity through inductive reasoning. While attempting to identify the essence of the landscape in the city and municipality of Óbidos, Portugal, several architectural recommendations of Venturi (2004) have been adapted as a framework for understanding this landscape. These will then guide the process of landscape transformation through: • • • using the concepts of closed and contained spaces and the concept of fluid space; • recognising the existence of interstitial open spaces; • using those elements which are common to the distinct typologies of space; • defining the components that should be respected and those that can be respected; • observing landscape as a whole , while emphasising the relationship between the parts and the whole; and • rejecting simplification in the landscape transformation process.valuing the ambiguity incorporating the complexity Underlying this approach is the belief that the process of transformation must be based on the essence of each landscape. This implies the use of elements and structures of the landscape which are related to ecological, morphological and cultural systems. These elements and structures represent points of reference which should be considered in the process of landscape transformation.
description: Landscape Review, Vol 13 No 1 (2009): Globalisation in Landscape Architecture
Semiclassical Gravity and Invisible Axions
Creators: name: Holman, R.
name: Kephart, T. W.
name: REY, Soo-Jong
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that charged Eguchi-Hanson instantons provide a concrete and calculable new source of intrinsic Peccei-Quinn symmetry breaking by quantum gravity. The size of this breaking is shown to depend sensitively on the short distance details of a given theory, but is generically suppressed by fermion zero modes. Demanding that these gravitational effects not affet the axion solution to the strong CP problem, we find that at least two sets of quarks with differing Peccei-Quinn charges are required. In addition, these effects obviate the cosmological axion domain wall problem but leave unchanged problems associated with coherent axion oscillations.
description: 13 pages, NSF-ITP-92-85
Short Distance Modification of a Gravitational System and its Optical Analog
Creators: name: Faizal, Mir
name: Zhao, Qin
name: Hou, Chenguang
name: Zaz, Zaid
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Physics (physics.gen-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Motivated by developments in string theory, such as T-duality, it has been proposed that the geometry of spacetime should have an intrinsic minimal length associated with it. This would modify the short distance behavior of quantum systems studied on such a geometry, and an optical analog for such a short distance modification of quantum system has also been realized by using non-paraxial nonlinear optics. As general relativity can be viewed as an effective field theory obtained from string, it is expected that this would also modify the short distance behavior of general relativity. Now the Newtonian approximation is a valid short distance approximation to general relativity, and Schrodinger-Newton equation can be obtained as a non-relativistic semi-classical limit of such a theory, we will analyze the short distance modification of Schrodinger-Newton equation from an intrinsic minimal length in the geometry of spacetime. As an optical analog of the Schrodinger-Newton equation has been constructed, it is possible to optically realize this system. So, this system is important, and we will numerical analyze the solutions for this system. It will be observed that the usual Runge-Kutta method cannot be used to analyze this system. However, we will use a propose and use a new numerical method, which we will call as the two step Runge-Kutta method, for analyzing this system.
description: 21 pages, 3 figures, 2 tables
Three-Dimensional Wave Behaviour of Light
Creators: name: Logiurato, Fabrizio
name: Danese, Beniamino
name: Gratton, Luigi
name: Oss, Stefano
Publisher: name: arXiv
Year: 2018
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: We describe a simple experimental apparatus which allows one to observe the wave properties of light in a new way. This apparatus also makes possible to introduce and illustrate, in a very suggestive way, some fundamental principles of quantum theory.
description: 3 pages, 2 figures, Conference Proceedings, The Foundations of Quantum Mechanics Historical Analysis and Open Questions, Cesena, Italy, 5-9 October 2004
The International Competition for the Reclamation of the Hiriya Landfill: A National Israeli Symbol in the ‘Global’ Arena
Creators: name: Alon-Mozes, Tal
Publisher: name: Landscape Review
Year: 2014

description: The recent international competition for the reclamation of the Hiriya landfill (2004), located in the centre of Israel’s metropolitan area, was the climax of a fiveyear project, in which the fifty-year-old landfill (1948–1998), Israel’s largest, became the focus of international artistic, planning and design activities. This paper discusses the Hiriya project in order to explore the reciprocity between local activity within the field of landscape architecture and the global arena of landscape architecture practice, focusing specifically on the reclamation of marginal landscapes. For many years, Hiriya served as a symbol of Zionists’ environmental neglect. Therefore, unsurprisingly, the reclamation of the site and the design of the metropolitan park surrounding it became a national symbol of regeneration, involving world-renowned experts. By examining the planning process, and particularly the recent design competition, this paper explores the relationship between the local and the global, and significantly, the difficulty of bridging these opposing stands visà- vis landscape reclamation. The design process proved that, to be part of the global arena, it is not enough to bring in foreign designers and let them play according to local rules. It requires frankness toward greater global cultural changes that are beyond the sole activity of design. The design proposals exemplify complex and rich interpretations of local and global ideas by both local and foreign designers, but ultimately proving that at times, outsiders are more successful in grasping the site’s genius loci than locals.
description: Landscape Review, Vol 13 No 1 (2009): Globalisation in Landscape Architecture
A Hybrid Decomposition Parallel Implementation of the Car-Parrinello Method
Creators: name: Wiggs, James K.
name: Jonsson, Hannes
Publisher: name: arXiv
Year: 1994
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We have developed a flexible hybrid decomposition parallel implementation of the first-principles molecular dynamics algorithm of Car and Parrinello. The code allows the problem to be decomposed either spatially, over the electronic orbitals, or any combination of the two. Performance statistics for 32, 64, 128 and 512 Si atom runs on the Touchstone Delta and Intel Paragon parallel supercomputers and comparison with the performance of an optimized code running the smaller systems on the Cray Y-MP and C90 are presented.
description: Accepted by Computer Physics Communications, latex, 34 pages without figures, 15 figures available in PostScript form via WWW at http://www-theory.chem.washington.edu/~wiggs/hyb_figures.html
Bioisosteric modification of Linezolid identified the potential M. tuberculosis protein synthesis inhibitors to overcome the myelosuppression and serotonergic toxicity associated with Linezolid in the treatment of the multi-drug resistance tuberculosis (MDR-TB)
Creators: name: Girase, Rukaiyya
name: Ahmad, Iqrar
name: Patel, Harun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Linezolid is the first and only oxazolidinone antibacterial drug was approved in the last 35 years. It exhibits bacteriostatic efficacy against M. tuberculosis and is a crucial constituent of the BPaL regimen (Bedaquiline, Pretomanid, and Linezolid), which was authorized by the FDA in 2019 for the treatment of XDR-TB or MDR-TB. Despite its unique mechanism of action, Linezolid carries a considerable risk of toxicity, including myelosuppression and serotonin syndrome (SS), which is caused by inhibition of mitochondrial protein synthesis (MPS) and monoamine oxidase (MAO), respectively. Based on the structure toxicity relationship (STR) of Linezolid, in this work, we used a bioisosteric replacement approach to optimize the structure of Linezolid at the C-ring and/or C-5 position for myelosuppression and serotogenic toxicity. Extensive hierarchical multistep docking, drug likeness prediction, molecular binding interactions analyses, and toxicity assessment identified three promising compounds (3071, 7549 and 9660) as less toxic potential modulators of Mtb EthR protein. Compounds 3071, 7549 and 9660 were having the significant docking score of −12.696 Kcal/mol, −12.681 Kcal/mol and −15.293 Kcal/mol towards the Mtb EthR protein with less MAO-A and B affinity [compound 3071: MAO A (-4.799 Kcal/mol) and MAO B (-6.552 Kcal/mol); compound 7549: MAO A (> −2.00 Kcal/mol) and MAO B (> −2.00 Kcal/mol) and compound 9660: MAO A (> −5.678 Kcal/mol) and MAO B (> −6.537Kcal/mol) and none of them shown the Leukopenia as a side effect due to the Myelosuppression. The MD simulation results and binding free energy estimations correspond well with docking analyses, indicating that the proposed compounds bind and inhibit the EthR protein more effectively than Linezolid. The quantum mechanical and electrical characteristics were evaluated using density functional theory (DFT), which also demonstrated that the proposed compounds are more reactive than Linezolid. Communicated by Ramaswamy H. Sarma
Anisotropic superconductivity and elongated vortices with unusual bound states in quasi-one-dimensional nickel-bismuth compounds
Creators: name: Wang, Wen-Lin
name: Zhang, Yi-Min
name: Lv, Yan-Feng
name: Ding, Hao
name: Wang, Lili
name: Li, Wei
name: He, Ke
name: Song, Can-Li
name: Ma, Xu-Cun
name: Xue, Qi-Kun
Publisher: name: arXiv
Year: 2018
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report low temperature scanning tunneling microscopy and spectroscopy studies of Ni-Bi films grown by molecular beam epitaxy. Highly anisotropic and twofold symmetric superconducting gaps are revealed in two distinct composites, Bi-rich NiBi3 and near-equimolar NixBi, both sharing quasi-one-dimensional crystal structure. We further reveal axially elongated vortices in both phases, but Caroli-de Gennes-Matricon states solely within the vortex cores of NiBi3. Intriguingly, although the localized bound state splits energetically off at a finite distance ~10 nm away from a vortex center along the minor axis of elliptic vortex, no splitting is found along the major axis. We attribute the elongated vortices and unusual vortex behaviors to the combined effects of twofold superconducting gap and Fermi velocity. The findings provide a comprehensive understanding of the electron pairing and vortex matter in quasi-one-dimensional superconductors
description: 7 pages, 7 figures
The sine-Gordon model and the small k^+ region of light-cone perturbation theory
Creators: name: Griffin, Paul A.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The non-perturbative ultraviolet divergence of the sine-Gordon model is used to study the $k^+ = 0$ region of light-cone perturbation theory. The light-cone vacuum is shown to be unstable at the non-perturbative $β^2 = 8π$ critical point by a light-cone version of Coleman's variational method. Vacuum bubbles, which are $k^+=0$ diagrams in light-cone field theory and are individually finite and non-vanishing for all $β$, conspire to generate ultraviolet divergences of the light-cone energy density. The $k^+ = 0$ region of momentum also contributes to connected Green's functions; the connected two point function will not diverge, as it should, at the critical point unless diagrams which contribute only at $k^+ = 0$ are properly included. This analysis shows in a simple way how the $k^+ =0$ region cannot be ignored even for connected diagrams. This phenomenon is expected to occur in higher dimensional gauge theories starting at two loop order in light-cone perturbation theory.
description: 8 pages, UFIFT-HEP-92-17
Constructing Resilience: The Wellington Studio
Creators: name: Allan, Penny
name: Roberts, Jamie
Publisher: name: Landscape Review
Year: 2014

description: This paper describes the results of a design studio on climate change at Victoria University of Wellington (VUW), New Zealand, in 2007. It discusses the processes and outcomes of the studio and the subsequent testing of student work against a resilience model developed by Canadian ecologist CS Holling (1973, 1998; Walker et al, 2004) to create a framework for the design of resilient cities.
description: Landscape Review, Vol 13 No 1 (2009): Globalisation in Landscape Architecture
Localising the Global: Landscape Architecture and Post-War Recovery in South Lebanon
Creators: name: Makhzoumi, Jala
Publisher: name: Landscape Review
Year: 2014

description: The scale of devastation following the July 2006 war in Lebanon resulted in a rush of international aid to address immediate needs and secure funding for reconstruction, while nationally, architects, urban designers and planners, among many others, volunteered to reclaim shelter and rebuild settlements. This paper investigates whether and in what ways landscape architecture, an emerging profession in Lebanon, can play a role in post-war recovery. A senior design studio project in the war-devastated village of El Qlaile in South Lebanon serves as a case study to elaborate method and outcome. Landscape architects, the case study demonstrates, are likely to contribute recovery narratives that integrate social, economic and environmental objectives and respond to place and everyday living needs and aspirations of local communities in rural Lebanon. The multifunctional community landscapes proposed prioritise livelihoods, valorise rural heritage and reaffirm village identity and pride in place. This in turn enables the local community to negotiate recovery priorities and offer their own agenda for future development.
description: Landscape Review, Vol 13 No 1 (2009): Globalisation in Landscape Architecture
Automatically assembling a full census of an academic field
Creators: name: Morgan, Allison C.
name: Way, Samuel F.
name: Clauset, Aaron
Publisher: name: arXiv
Year: 2018
Subjects: subject: Digital Libraries (cs.DL)
subject: Computers and Society (cs.CY)
subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The composition of the scientific workforce shapes the direction of scientific research, directly through the selection of questions to investigate, and indirectly through its influence on the training of future scientists. In most fields, however, complete census information is difficult to obtain, complicating efforts to study workforce dynamics and the effects of policy. This is particularly true in computer science, which lacks a single, all-encompassing directory or professional organization. A full census of computer science would serve many purposes, not the least of which is a better understanding of the trends and causes of unequal representation in computing. Previous academic census efforts have relied on narrow or biased samples, or on professional society membership rolls. A full census can be constructed directly from online departmental faculty directories, but doing so by hand is prohibitively expensive and time-consuming. Here, we introduce a topical web crawler for automating the collection of faculty information from web-based department rosters, and demonstrate the resulting system on the 205 PhD-granting computer science departments in the U.S. and Canada. This method constructs a complete census of the field within a few minutes, and achieves over 99% precision and recall. We conclude by comparing the resulting 2017 census to a hand-curated 2011 census to quantify turnover and retention in computer science, in general and for female faculty in particular, demonstrating the types of analysis made possible by automated census construction.
description: 11 pages, 6 figures, 2 tables
Dimensional coupling induced current reversal in two-dimensional driven lattices
Creators: name: Mukhopadhyay, Aritra K.
name: Xie, Tianting
name: Liebchen, Benno
name: Schmelcher, Peter
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We show that the direction of directed particle transport in a two dimensional ac-driven lattice can be dynamically reversed by changing the structure of the lattice in the direction perpendicular to the applied driving force. These structural changes introduce dimensional coupling effects, the strength of which governs the timescale of the current reversals. The underlying mechanism is based on the fact that dimensional coupling allows the particles to explore regions of phase space which are inaccessible otherwise. The experimental realization for cold atoms in ac-driven optical lattices is discussed.