cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting a Novel Lung Cancer Membrane Vulnerability through Pulsed Magnetic Fields
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: As the leading cause of cancer death in the U.S. and worldwide, lung cancer develops as a result of tobacco use in the vast majority of cases. Tobacco induced cancer develops with unique alterations in a carbohydrate (or “sugar”) layer of molecules on the tumor-cell surface known as the glycocalyx. In discovery work, we found that applying an external “pulsed” magnetic field to lung cancer cells may induce novel electric forces (EMFs) that engage with charged sugars uniquely enriched on the glycocalyx of the cancer cells, inducing tumor-cell leak and reduced tumor cell viability. The pulsed fields appear to engage with tumor glycans to disrupt the integrity of the tumor cell’s surface or membrane. Such unique sugars are expressed heavily on the glycocalyx of lung tumors, and might thus represent a novel “Achilles heel” or vulnerability of lung cancer cells to treatment using pulsed magnetic fields, while normal cells appear to be spared in studies thus far. Biophysical approaches to target lung cancer remain under-explored, and we aim to study how pulsed magnetic fields target lung cancer cell systems, including pilot work to inhibit the growth of tobacco-induced model human lung tumors in mice. This may facilitate novel therapeutic approaches to eradicate tumor cells without classical radiation or chemotherapy that can damage normal surrounding body cells. We hypothesize that EMFs generated by pulsed magnetic fields can: (1) engage with unique “charged glycan” arrays on the glycocalyx of tobacco induced lung cancer cells to disrupt tumor membrane integrity, and (2) inhibit cancer-cell viability in human lung tumor models growing in mice treated with short exposures to the novel pulsed fields. Lung cancer recurs frequently, and non-toxic strategies to cure micro-metastatic disease are needed. Applying pulsed magnetic fields in a treatment setting may potentially eradicate “visible and invisible” tumor with high impact. In addition, proposed pilot studies will inform the specific impact on tobacco-induced lung cancers, including any unique susceptibility of their glycocalyx to pulsed fields. Finally, we have an eye to the fact that the cancer glycocalyx is known to augment a cancer’s invasive potential, so the use of pulsed fields to target glycocalyx-rich tumor cells may uniquely eradicate highly invasive tumor cell subsets to further improve outcomes.
The effects of vaping during pregnancy on placental biology and offspring development
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Tobacco and nicotine addiction have significant adverse effects on our society's health, particularly affecting vulnerable groups such as pregnant women and adolescents, who are often underrepresented in related studies. With the rising use of e-cigarettes across different age groups and the legalization of cannabis in many U.S. states, it has become crucial to gain a deeper understanding of the impact of nicotine and cannabinoid co-exposure on neural development and function. Maintaining proper placental development and function is vital for a healthy pregnancy and the well-being of the developing fetus. Any factors influencing placental maturation can potentially disrupt fetal growth and development. Both nicotine and delta -9-tetrahydrocannabinol (THC) found in cannabis can cross the placenta and blood-brain barrier, concentrating in fetal blood and amniotic fluid. The primary objective of this research is to explore the effects of nicotine and cannabinoid co-exposure during pregnancy on communication between the placenta and fetus, neural development and cognitive flexibility. To achieve this, the proposed studies will systematically investigate the impact of prenatal exposure to vaped e-cigarette nicotine and THC on the molecular extracellular mechanism between the placenta and fetus, as well as its genetic implications. To study these effects, a combination of in vivo and in vitro approaches will be utilized, focusing on how vapor co-exposure of nicotine and THC during pregnancy influences extracellular communication in the placenta-fetus axis, potentially altering extracellular vesicles (EV) cargo and increasing vulnerability to cognitive flexibility in adolescent rats. The data obtained from this study will significantly contribute to our fundamental knowledge of how prenatal drug exposure affects the critical placenta-fetus communication mechanism neural function and cognitive flexibility. Furthermore, the findings could inform the development of public policies aimed at educating pregnant women about the impact of drug exposure on the developing fetus. Additionally, the research outcomes will enhance our understanding of the genetic and behavioral profiles of childhood neurodevelopmental disorders, potentially leading to novel therapeutic approaches.
NNR918841_Supplementary_material_CLN – Supplemental material for Motor Skill Training May Restore Impaired Corticospinal Tract Fibers in Children With Cerebral Palsy
Creators: name: Bleyenheuft, Yannick
name: Dricot, Laurence
name: Ebner-Karestinos, Daniela
name: Paradis, Julie
name: Saussez, Geoffroy
name: Renders, Anne
name: Volder, Anne De
name: Araneda, Rodrigo
name: Gordon, Andrew M.
name: Friel, Kathleen M.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, NNR918841_Supplementary_material_CLN for Motor Skill Training May Restore Impaired Corticospinal Tract Fibers in Children With Cerebral Palsy by Yannick Bleyenheuft, Laurence Dricot, Daniela Ebner-Karestinos, Julie Paradis, Geoffroy Saussez, Anne Renders, Anne De Volder, Rodrigo Araneda, Andrew M. Gordon and Kathleen M. Friel in Neurorehabilitation and Neural Repair
Supplemental_material_TOP - Short-Term Study Abroad in Psychology: Effects of a Cultural Scavenger Hunt on the Development of Intercultural Competence
Creators: name: Zayac, Ryan M.
name: Miller, Sydney
name: Lenhard, Wolfgang
name: Paulk, Amber
name: Chrysler, Kirby
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental_material_TOP for Short-Term Study Abroad in Psychology: Effects of a Cultural Scavenger Hunt on the Development of Intercultural Competence by Ryan M. Zayac, Sydney Miller, Wolfgang Lenhard, Amber Paulk and Kirby Chrysler in Teaching of Psychology
Deciphering mechanisms of p53 action in AT1 cell fate determination and lung cancer suppression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the most common cancer worldwide. Among lung cancer subtypes, lung adenocarcinoma (LUAD) is the most common one and a leading cause of cancer deaths in the United States. Smoking tobacco is a major cause of lung cancer, which is responsible for approximately 90% of all cases. Tobacco-derived carcinogens induce mutations in oncogenes and tumor suppressor genes, thereby triggering the transformation of normal lung cells to cancer cells. Among the susceptible genes, TP53, an essential tumour suppressor gene, is one of the most mutated genes in LUAD, with alterations in ~50% of LUAD. Mutations in TP53 are also associated with poor prognosis of lung cancer patients, indicating the critical roles of TP53 in restraining LUAD development and malignant transformation. P53 is a transcriptional activator protein that induces expression of a host of downstream target genes. Despite the crucial roles of TP53 in suppressing lung cancer initiation and progression, however, the underlying mechanisms by which p53 acts remain uncompletely understood. LUAD arises in the gas-exchange region of the lung, the alveoli, from alveolar type 2 (AT2) cells, cuboidal cells that secrete pulmonary surfactants and serve as a stem cells pools for generating additional AT2 cells and for differentiation into thin and quiescent alveolar type 1 (AT1) cells which mediate gas exchange. During lung injury repair, AT2 cells are activated to proliferate and form cells known as transitional cells, which eventually differentiate into AT1 cells. Importantly, our recent studies in mouse models revealed that p53 is activated in transitional cells during injury repair and in response to oncogenic insults in the lung. We showed further that p53 inactivation prevents transitional cells from becoming AT1 cells in LUAD and in tissue regeneration after injury. Our findings suggest that p53 restricts LUAD by promoting an AT1 differentiation gene expression program, but the genes required for p53 to induce AT1 differentiation are unknown. In addition, whether AT1 differentiation is critical for p53-mediated tumor suppression is unclear. Our experiments will address these two questions. Achieving these goals will shed light on mechanisms of p53 action in suppressing LUAD development, thereby opening new opportunities for lung cancer prevention and treatment.
The role of the colon microbiota in the Mexican children obesity
Creators: name: Murugesan, Selvasankar
name: García-Mena, Jaime
name: Pizano-Zárate, Maria Luisa
name: Maya, Otoniel
name: Galván-Rodríguez, Flor María
name: Miranda-Brito, Carolina
name: Romano, Marta
name: Piña-Escobedo, Alberto
name: Hoyo-Vadillo, Carlos
Publisher: name: Journal of International Society of Microbiota
Year: 2016

description: Background
Obesity is epidemic in Mexico, and among several other factors, the colon microbiota which produces short chain fatty acids by fermentation of undigested carbohydrates, plays an important role. Changes in the colon microbial diversity of Mexican children may affect nutrient absorption and contribute to development of obesity.
Method
Normal-weight (n=81), overweight (n=29), and obese Mexican children (n=80) aged 9-11 were selected. V3-16S rDNA libraries were prepared from fecal DNA and high-throughput sequenced1. After QIIME analysis of data, metabolic profile was done using PICRUSt2.
Results
The bacterial genera Blautia spp, Faecalibacterium spp and Coprococcus spp were significantly increased in overweight and obese children. Principal component analysis revealed association of these bacteria with increased BMI and triglycerides in overweight and obese children. Functional profile prediction disclosed that fatty acids, and lipid biosynthesis functional genes were significantly more abundant in obese children. Three different enterotypes were identified associated to these changes.
Conclusion
We conclude that a particular colon microbiota imbalance with different enterotype patterns in overweight and obese children, increases fatty acid and lipid production. These changes are associated with the increase of BMI and triglycerides in overweight and obese children.
description: Journal of International Society of Microbiota, Vol 3, No 1 (2016)
LYTAC targeting galectin-1 to enhance radioimmunotherapy of tobacco-related cancers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Tobacco smoking is a major cause of two types of cancer: non-small cell lung cancer (NSCLC) and head and neck cancer (HNC). These cancers are significant contributors to cancer-related deaths and are among the most common cancers worldwide. While treatments for these cancers have improved, there is still a need for better therapies to help patients live longer and improve their quality of life. A recent breakthrough in cancer treatment involves a new method called lysosome-targeted chimera (LYTAC), which was reported in the journal Nature by Carolyn Bertozzi’s research group. LYTAC targets proteins that promote cancer growth to either degrade or remove them. They've successfully tested this approach on several cancer-promoting proteins in cells, including epidermal growth factor receptor (EGFR). However, before this method can be used in clinics, its effectiveness in activating the immune system and controlling tumor growth in different animal models needs to be thoroughly tested. Our research has focused on a protein called galectin-1 (Gal-1), which is found in high levels in HNC and NSCLC. Gal-1 suppresses the immune system in cancer by binding to receptors on immune cells, leading to the death of anticancer T cells, promoting cancer-supporting T cells, and attracting immune-suppressing cells into tumors. Despite its potential as a target for immunotherapy, there is currently no effective treatment targeting Gal-1 available. In collaboration with Bertozzi’s group, we've developed the first LYTAC degrader called G-M6Pn, which can degrade Gal-1 in human HNC cells. Our study aims to investigate the effects of G-M6Pn on NSCLC cells and its ability to activate key immune cells, control tumor growth and metastasis, and improve survival rates in animal models by eliminating Gal-1. We also plan to explore how G-M6Pn can enhance tumor-killing immune responses when combined with radiotherapy in animal models. We hope that this research will lay the groundwork for using LYTAC degraders to improve the treatment outcomes of tobacco-related cancers in the future.
Ctenoscelis (Ctenoscelis) coeus
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Ctenoscelis
Ctenoscelis coeus

description: * 3. Ctenoscelis (Ctenoscelis) coeus (Perty, 1832)
 Prionus coeus Perty, 1832: 86, est. 17, fig. 5.
 Material examinado: Araguanã (Alto Rio Turiaçu, Reserva Indígena Awaguajá), macho, 17-20.III.2002, F. Limeira-de-Oliveira & J.T. Câmara col., armadilha luminosa; macho, 17-20.III.2002, F. Limeira-de-Oliveira & J.T. Câmara col., armadilha Malaise; Caxias (Reserva Ecológica Inhamum), fêmea, 02-05.IV.2006, M.M.B.G. Jesus Junior col., armadilha “Pitt fall”; macho, 01-02.II.2006, C.O. Lima & M.C. Souza col.; fêmea, 06-07.III.2006, A.S.S. Costa col.; fêmea, 26-30. I.2008, R.R. Almeida col.; fêmea, 06-07.III.2006, A.S.S. Costa & F.C.G. Santana col.; fêmea, 15-16. II.2006, F.C.G. Santana col.; fêmea, 24.II.2006, F. Limeira-de-Oliveira col.; fêmea, 13.III.2006, F. Limeira-de-Oliveira col., rede entomológica; macho, 27.II-01.III.2006, F. Limeira-de-Oliveira & J.C. Silva col., lençol e luz mista; (Campus CESC/UEMA), fêmea, 10-20.II.2008, F. Limeira-de-Oliveira col.; fêmea, 20-30.II.2008, F. Limeira-de-Oliveira col., lâmpadas brancas; (Fazenda Nova), macho, 25-26. II.2004, F. Limeira-de-Oliveira et al. col.; Mirador (Parque Estadual Mirador, Base da Geraldina), 3 machos, 20-24.XII.2006, R.O. Souza & J.C. Silva col., armadilha luminosa; macho, 17-21.II.2007, J.C. Silva & M.J. A. Holanda col.
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 230, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
Characterizing neuromuscular and respiratory muscle performance declines limiting exercise in COPD
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Chronic obstructive pulmonary disease (COPD) is a lung disease predominantly caused by tobacco smoking. There is no cure for COPD, therefore treatment focuses on alleviating patient symptoms. One of the most common symptoms reported by COPD patients is exercise intolerance. However, in COPD patients the standard measure of exercise intolerance (V̇O2peak) is poorly related to the severity of the decline in lung function. Therefore, although COPD is a ‘lung disease’, this well-appreciated finding affirms that leg muscle dysfunction also contributes to exercise intolerance in COPD patients. We have developed a new exercise test that adds the assessment of leg muscle performance to a standard test that measures V̇O2peak. This allows us to identify whether the “legs” or the “lungs” limit exercise tolerance. This test can also characterize how quickly leg muscle performance declines during an exercise test. Preliminary data, in healthy people, shows that leg muscle performance primarily limits exercise tolerance. However, in COPD patients the reserve in leg muscle performance at the point of exercise intolerance can be substantial. Moreover, the muscles that support breathing can also be dysfunctional in patients with COPD. It has been proposed that signals from these breathing muscles to the brain can result in exercise intolerance before the limits of leg muscle performance are reached. However, it is unclear how leg muscle performance declines during an exercise test in COPD patients. It is also unclear how breathing muscle dysfunction affects the decline in leg muscle performance and exercise tolerance in COPD patients. This project will 1. Characterize the decline in leg muscle performance during exercise and 2. Investigate how adding or reducing the work done by the breathing muscles affects the decline in leg muscle performance. These data will significantly advance our knowledge of the basic mechanisms of exercise intolerance in COPD and our understanding of how breathing muscle dysfunction affects the decline in leg muscle performance and exercise tolerance. This knowledge is essential for understanding how best to design effective treatment strategies to alleviate symptoms in COPD patients.
Additional file 1 of Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis
Creators: name: Kohle, Felix
name: Ackfeld, Robin
name: Hommen, Franziska
name: Klein, Ines
name: Svačina, Martin K. R.
name: Schneider, Christian
name: Fink, Gereon R.
name: Barham, Mohammed
name: Vilchez, David
name: Lehmann, Helmar C.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified

description: Additional file 1. Material S1.
Examining the effects of cytisinicline on neural substrates of cigarette cue-reactivity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking is the leading cause of preventable disease and premature death worldwide. The majority of smokers report a desire to quit smoking; however only 3-5% of unaided quit attempts are successful. Pharmacotherapy for smoking cessation increases odds of abstinence, but the current FDA-approved options are associated with modest long-term quit rates that rarely exceed 30%. Furthermore, these medications are often accompanied by adverse events that deter utilization. There is a pressing need for alternative smoking cessation medications. A recent phase 3 clinical trial found cytisinicline, a naturally occurring plant-based alkaloid, to be an effective, safe, and well-tolerated pharmacotherapy to promote smoking cessation. Unlike the current FDA-approved pharmacotherapies, cytisinicline is widely accessible and cost-effective. Despite promising clinical findings, cytisinicline’s effects on the human brain are unknown. The objective of this TRDRP postdoctoral application is to advance the neuroscience of nicotine addiction treatment and medication development for smoking cessation. I will use neuroimaging and daily diary self-report assessments to examine cytisinicline’s effects on the human brain and test the brain processes that underlie variability in cytisinicline response. 34 adult daily smokers (50% female) will complete a randomized, within-subject, crossover, double-blind, placebo-controlled laboratory study of cytisinicline. Specifically, participants will complete two 7-day outpatient protocols that include taking cytisinicline (3 mg, 3 times daily) or placebo, and completing daily diary self-reports of cigarette craving and reward. On day 7, participants will complete a cigarette cue-exposure task during fMRI. Specific aims are to test (1) the effects of cytisinicline on neural reward signal to cigarette cues, (2) the effects of cytisinicline on smoking subjective effects, including (a) cigarette craving and (b) reward, and (3) the neural processes that predict variability in response to cytisinicline (i.e., craving and reward). The execution of this project will (a) identify the neural mechanisms underlying cytisinicline’s actions as a smoking cessation treatment and variability in cytisinicline response; and (b) foster my scientific development as an independent clinical neuroscientist with a focus on tobacco use disorder.
Additional file 1 of Point-of-Care-ultrasound in undergraduate medical education: a scoping review of assessment methods
Creators: name: DeBiasio, Celina
name: Pageau, Paul
name: Shefrin, Allan
name: Woo, Michael Y.
name: Cheung, Warren J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1: Supplement 1, Scoping review search strategy.
Using a human in vitro platform to study the effects of cannabinoids on the cardiovascular system
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: E-cigarettes, which are increasingly popular among young people, are often marketed as a safer alternative to traditional smoking devices. They come in a variety of enticing flavors, including marijuana. Strikingly, some e-cigarettes contain new compounds designed to heighten the sensory experience or market health benefits like better sleep and reduced inflammation. However, these products may have unknown health risks due to the compounds used, such as hexahydrocannabinol HHC for its stimulating effects or cannabinol (CBN) for its supposed medicinal properties. This project aims to bring clarity to this issue by studying the possible heart-related health effects of these compounds. I will generate stem cells from a variety of healthy individuals, which will then be used to create cell populations resembling important heart cells. I will then expose these cell groups to the e-cigarette compounds HHC, CBN, and a conventional compound, tetrahydrocannabinol (Δ9-THC), to see how they may affect the heart. By exploring how different heart cells interact when exposed to these compounds, we can better understand the potential effects of e-cigarettes on the heart. The knowledge we gain will then be expanded on using animal models and a smoking machine, which imitates the human consumption of e-cigarettes. This will enable us to more accurately determine the compounds' short- and long-term effects on heart health. This study aims to provide crucial information that will help us understand the risks associated with e-cigarettes, potentially shielding public health from unknown threats posed by these popular devices.
Additional file 2 of Point-of-Care-ultrasound in undergraduate medical education: a scoping review of assessment methods
Creators: name: DeBiasio, Celina
name: Pageau, Paul
name: Shefrin, Allan
name: Woo, Michael Y.
name: Cheung, Warren J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 2: Supplement 2, Included studies and Miller's level of assesment.
Supporting Parents' Knowledge and Communication Strategies for Preventing Adolescent E-cigarette Use
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: E-cigarettes have become highly popular among adolescents within the last decade. National surveys estimate that over 2.5 million middle and high school students are currently using e-cigarettes. High rates of adolescent e-cigarette use are concerning given documented health harms from e-cigarette use to adolescents’ heart, lungs, and brain. Health risks associated with adolescent e-cigarette use have prompted the development of prevention programs designed to reduce adolescent e-cigarette initiation and use. Though most prevention programs are designed for implementation in school settings, parents can also play an important role in preventing their adolescents’ general tobacco use through setting clear expectations and discussing health risks. However, many parents lack knowledge of e-cigarettes and their health harms, especially since e-cigarette designs, ingredients, and health harms change frequently. Parents’ poor knowledge and misperceptions regarding e-cigarettes are likely to undermine their efforts to proactively discuss e-cigarettes with their adolescents and prevent their initiation and use. Notably, there is a lack of up-to-date e-cigarette prevention programs designed for use by parents with their adolescents. To develop such programs, more research is required to assess parents’ knowledge and perceptions regarding e-cigarette products, and to determine the prevention content, messages, communication strategies, format, and resources that would be most beneficial to parents. To address these gaps, we will conduct surveys and focus groups with parents to assess their e-cigarette knowledge, perceptions, household rules about use, and communication strategies. We will also assess their needs and preferences for a parent-based e-cigarette prevention toolkit. Data collected will provide new insights into parent perspectives on adolescent e-cigarette use, and inform the development of a parent-based e-cigarette prevention program.
Achryson surinamum
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Achryson
Achryson surinamum

description: * 8. Achryson surinamum (Linnaeus, 1767)
 Cerambyx surinamus Linnaeus, 1767: 632.
 Material examinado: Caxias (Sitio São Francisco, Distrito Itapecuruzinho), macho, 15-16.V.1999, J.T. Câmara; M.A.F. Silva & F. Limeira-de-Oliveira col., armadilha luminosa; (Reserva Ecológica Inhamum), macho, 30.X-02.XI.2005, F. Limeira-de-Oliveira col., luz mista; (Campus, CESC), 2 fêmeas, 21.I.1999, R.C. Bastos col.; Mirador (Parque Estadual Mirador, Base da Geraldina), macho, 22-26.VIII.2006, F. Limeira-de-Oliveira col., armadilha luminosa.
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 233, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
Investigate Genetic Drivers and Dependencies in Lung Adenocarcinoma to Combat Tobacco-Related Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the leading cause of cancer death and is often caused by tobacco smoking. Over the past year, scientists have worked hard to identify and categorize gene changes, known as mutations, in lung cancer patients. Understanding these mutations is crucial because they are often the starting point for cancer; they can turn normal cells into cancer cells by disrupting normal cell functions. Although we've found many mutations, understanding what each mutated gene does is still a challenge. This is because each tumor can have hundreds or thousands of different mutations, making it difficult to pinpoint which ones are critical. To tackle these challenges, we will take an innovative approach. we plan to use advanced gene-editing tools and detailed experiments to build a detailed map of how genes affect lung cancer development, specifically lung adenocarcinoma, a common type of lung cancer. Our research will focus on testing the roles of the 10,000 most active genes in a special breed of mice that have lung cancer driven by a specific gene change known as oncogenic KRAS. We aim to understand how some genes help stop tumors from growing and how others are essential for the tumor’s survival, which might become targets for new cancer drugs. This large-scale study will allow us to explore these genes' roles thoroughly and could lead to breakthroughs in how we understand and treat lung cancer. The insights gained could reveal how tumors start and grow, providing valuable information for developing better treatment strategies.
Investigating Smoking Cessation Behaviors and Tobacco and Cannabis Use in Pancreatitis Patients
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Pancreatitis (chronic or acute) is the inflammation of the pancreas, with acute pancreatitis (AP) accounting for >300,000 hospital admissions annually in the US. Recurrence of AP is a risk factor for chronic pancreatitis and pancreatic cancer. Tobacco smoking is a modifiable causal factor in pancreatitis and is commonly overlooked in medical management. Even when offered quit interventions, quit rates among patients are low. Pancreatitis causes intense pain, and patients report reliance on smoking and other substances for pain relief. Nicotine replacement to quit smoking is questioned based on evidence that nicotine itself may increase AP risk. Despite the unique and important need for pancreatitis patients to stop smoking, no tailored guidelines or tools are available for them. Given the rising rates of cannabis-induced pancreatitis, understanding how cannabis use (alone or combined with tobacco) impacts tobacco quitting behaviors is a major knowledge gap for this patient group. To better understand tobacco and cannabis behaviors in pancreatitis patients, with the long-term goal of developing more effective smoking cessation strategies for this population, we will investigate tobacco and cannabis use in one of the largest studies of pancreatitis patients being followed for recurrence. We will examine how tobacco and cannabis use impact the recurrence of AP. In addition, we will conduct a qualitative study of 30 participants to gain deeper insight into the tobacco use behaviors in the population, including awareness of the associated risk for recurrent disease and probing the role of stress and pain in use and quit behavior. The combined results will guide the design of interventional strategies to reduce tobacco and/or cannabis smoking in pancreatitis patients. Completion of the mentored research will provide a better understanding of the patterns of cannabis and tobacco use in pancreatitis patients and prepare the Principal Investigator with the skills needed to carry out research on tobacco-related disorders, including research design, synthesis of evidence, statistical analysis, interpretation and communication of findings, and research management. In turn, the project will propel her to become a leader in tobacco research and focus on developing more effective and tailored smoking cessation interventions to reduce the harms attributed to tobacco.
supplemental_material – Supplemental material for Predictive Properties of the Violence Risk Scale–Sexual Offense Version as a Function of Age
Creators: name: Olver, Mark E.
name: Christofferson, Sarah M. Beggs
name: Nicholaichuk, Terry P.
name: Wong, Stephen C. P.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, supplemental_material for Predictive Properties of the Violence Risk Scale–Sexual Offense Version as a Function of Age by Mark E. Olver, Sarah M. Beggs Christofferson, Terry P. Nicholaichuk and Stephen C. P. Wong in Assessment
Precision prevention of tobacco-associated oral cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Oral cancer poses a significant global health threat, with only about 63% of patients survive for 5 years after being diagnosed. Tobacco use is a risk factor for oral cancer, and patients with tobacco-related oral cancer typically exhibit poor responses to current treatments. The challenge in treating tobacco-associated oral cancer lies in the absence of effective treatment options for the tumor and its surrounding immune environment. Our team discovered that the activation of a molecule known as mTOR in oral lesions that precede cancer contributes to their progression to malignancy. This indicates that reducing the activation of mTOR and its molecular network holds promise as a strategy to impede the progression of oral cancer from oral premalignant lesions. Interestingly, our lab showed that metformin, a safe drug used by millions of type 2 diabetes patients, can diminish mTOR activation in oral premalignant lesions and halt their progression to cancer. Based on these findings, our team conducted a Phase 2 trial in individuals with oral premalignant lesions to investigate metformin's potential in preventing oral cancer. The results from this clinical trial suggest that metformin use may reduce cancer progression. Notably, current and former smokers responded more favorably to metformin compared to never smokers. However, we still do not know the factors influencing metformin's efficacy in preventing the progression of oral premalignant lesions to oral cancer. My work will investigate the hypothesis that (1) the specific genetic alterations promoting mTOR activation in oral premalignant lesions and (2) the surrounding immune environment may dictate metformin's sensitivity. We will explore this hypothesis using recently developed mouse models that reflect closely the genetic complexity of tobacco-associated human oral cancer. Subsequently, we will validate our findings with collected information from our cancer prevention trial. By unraveling this knowledge, I aim to identify molecular alterations that can predict clinical responses to metformin and develop new drug combination strategies to enhance metformin’s efficiency. Our collective efforts strive to maximize the therapeutic potential of metformin as a safe, accessible and low-cost drug to reduce oral cancer in tobacco-burdened communities.
sj-docx-1-psx-10.1177_0032321719884712 – Supplemental material for Explaining the Constitutional Integration and Resurgence of Traditional Political Institutions in Sub-Saharan Africa
Creators: name: Holzinger, Katharina
name: Kern, Florian G
name: Kromrey, Daniela
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, sj-docx-1-psx-10.1177_0032321719884712 for Explaining the Constitutional Integration and Resurgence of Traditional Political Institutions in Sub-Saharan Africa by Katharina Holzinger, Florian G Kern and Daniela Kromrey in Political Studies
Staff_Survey – Supplemental material for Evaluation of prevention of ventilator-associated infections in four Australian intensive care units
Creators: name: Ciampoli, Natasha
name: Stephane Bouchoucha
name: Currey, Judy
name: Hutchinson, Ana
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, Staff_Survey for Evaluation of prevention of ventilator-associated infections in four Australian intensive care units by Natasha Ciampoli, Stephane Bouchoucha, Judy Currey and Ana Hutchinson in Journal of Infection Prevention
Coccoderus longespinicornis Fuchs 1964
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Coccoderus
Coccoderus longespinicornis

description: 11. Coccoderus longespinicornis Fuchs, 1964
 Coccoderus longespinicornis Fuchs, 1964: 7.
 Material examinado: Mirador (Parque Estadual Mirador, Base da Geraldina), fêmea, 27-30.IX.2006, F. Limeira-de-Oliveira & J.A. Rafael col., armadilha luminosa.
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 233, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
Evaluation of California Tobacco Control Policies and Their Influence Among Youth in California
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Despite a downward trend in tobacco use since the 1960s, combustible cigarettes remain a leading cause of preventable disease and death within the United States. Various tobacco policies, including Tobacco 21, smoke-free outdoor policies, and, more recently, the banning of flavored tobacco products, have been introduced with the aim of reducing tobacco use and improving overall quality of life. Alongside these efforts, researchers have also examined harm reduction strategies such as Electronic Nicotine Device Systems (ENDS), which show evidence improving quit rates to help combat the upward trends in tobacco use. Although ENDS can improve quit rates among adults, they are also gaining popularity among youth. The 2021 National Youth Tobacco Survey (NYTS) reported that 11.3% of high school and 2.8% of middle school students use ENDS. Over the past decade, ENDS has sparked a debate among tobacco researchers regarding the benefits versus risks of these products. While ENDS can serve as a harm reduction strategy, they are not an FDA-approved cessation tool and research has shown that these devices contain chemicals that can be harmful to one's health. Upon entering the market, ENDS products targeted young adults with alluring advertisements. Due to the growing concerns about ENDS, California Proposition 56 officially classified ENDS as tobacco products in 2016, subjecting them to all existing tobacco policies. Although tobacco policies are in place to reduce tobacco use, there is no standardized approach to assess their effectiveness. The American Lung Association (ALA) has developed state tobacco grades that evaluate the enforcement of tobacco policies at the state, city, and county levels. These grades are based on laws related to smoke-free outdoor air, smoke-free housing, reducing the sale of tobacco products, and, more recently, restrictions on flavored tobacco products. However, these grades have not been utilized in any study to assess the effectiveness of tobacco policies. The purpose of this project is to evaluate the effectiveness of tobacco policies among different sociodemographic groups within California's youth.
Habenula Circuitry and Early Use of Tobacco Products
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The use of tobacco products is a leading cause of preventable death and illness in California and worldwide. Early age and racial/ethnic minority status confer increased risk of using these products along with associated negative health outcomes. Youths are more vulnerable to nicotine addiction following exposure due to an earlier maturation of reward circuitry as compared with inhibitory control circuits in the brain. Furthermore, minority status is associated with the faster transition from initiation of tobacco product use to tobacco dependence. Neural mechanisms likely play a role as causes for these disparities. We propose that there are differences in habenula circuitry between school-aged youth who ultimately go on to use tobacco products compared with those who do not. Racial/ethnic minority status likely modulates possible differences. The habenula is a brain region that responds strongly to nicotine in animals and densely expresses the gene most strongly linked to nicotine dependence in humans. It also is implicated more generally in addiction-related behavior and negative affective states. As such, the circuitry of the habenula may have bearing on initiation and transition to heavy use of tobacco products. Yet the human habenula has eluded study because of its size and the difficulty in segmenting it from adjacent structures of the brain. We will use new analytical techniques that make it possible to segment the habenula from surrounding regions in brain scans using Magnetic Resonance Imaging (MRI) and explore its functional connectivity in relation to vulnerability to tobacco product use during early adolescence. We will analyze data from the Adolescent Brain Cognitive Development Study (ABCD), which provides longitudinal MRI and smoking-related data from 11,875 children, including subsamples of individuals from different racial/ethnic minority groups. We will assess functional connectivity of the habenula to two targets in the brain: the ventral tegmental area, an important component of the brain’s reward circuitry, and the salience network, which is linked to nicotine dependence. The findings can provide important information about the circuits related to nicotine addiction and disparities in the negative consequences of tobacco product use.
Understanding how immune cells protect against tobacco-associated head and neck cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Tobacco use greatly increases the risk of many cancers and accounts for 25% of all cancer deaths worldwide. Head and neck cancers (HNC), the majority of which arise from tobacco use, are becoming increasingly common. Patients with HNC have poor response to available therapies and high mortality rates. The body’s immune system plays an integral part in killing cancer cells: increased numbers of tumor-infiltrating immune cells has been reported to correlate with better cancer prognosis. Boosting the immune response has thus been a considerable focus of cancer treatment strategies. However, the effectiveness of immune-boosting therapies in HNC remains unexpectedly low, highlighting the need for a better understanding of immune-tumor interactions in order to improve the treatment of HNC. In recent years, immunologists have gained insight into a subset of immune cells termed “tissue-resident memory CD8+ T cells,” or “TRM” for short. Compared to other immune cell types, TRM possess a distinctive ability to surveil tissues and quickly respond to threats of infection and cancer growth. The robust function of TRM in tissues is thought to underlie improved patient outcomes in many cancer types such as colorectal, breast, and lung cancers. What is known about TRM mostly stem from studies in mouse models of infection and less so models of cancer. Furthermore, while TRM in many different organs have been investigated, our knowledge of the characteristics and function of TRM in head and neck tissues remain severely limited. Because of their unique protective capabilities, improving our understanding of basic TRM biology in the context of HNC potentiates new targets for boosting antitumor immunity for cancer treatment. In this proposal, I will study TRM in a mouse model of tobacco-associated HNC. This mouse HNC model shares 94% genetic similarity with human HNC, making my findings applicable to human disease. I will (1) characterize the properties of TRM in mouse HNC, and evaluate the tumor-fighting abilities of TRM compared to other immune cell types. In light of exploring novel therapeutic targets, I will also (2) identify cellular factors that regulate TRM in mouse HNC. My project provides an opportunity to deepen our understanding of immune cell biology within tumor tissues, uncovering new ways of tackling tobacco-associated HNC to improve patient outcomes.
sj-pdf-4-joh-10.1177_0020731420923532 - Supplemental material for Socioeconomic Inequalities in Small-for-Gestational-Age Births Before and During the Economic Crisis: An Ecologic Study of Trends in 13 Spanish Cities
Creators: name: Domínguez-Berjón, María Felícitas
name: Glòria Pérez
name: Gotsens, Mercè
name: Gènova, Ricard
name: Martín, Unai
name: Ruiz-Ramos, Miguel
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-4-joh-10.1177_0020731420923532 for Socioeconomic Inequalities in Small-for-Gestational-Age Births Before and During the Economic Crisis: An Ecologic Study of Trends in 13 Spanish Cities by María Felícitas Domínguez-Berjón, Glòria Pérez, Mercè Gotsens, Ricard Gènova, Unai Martín, Miguel Ruiz-Ramos and the IMCRISES Project Working Group in International Journal of Health Services