cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Food size selectivity and diet overlap in larvae of Clupeiform species from central Chile
Creators: name: LLANOS-RIVERA, Alejandra
name: HERRERA, Guillermo
name: BERNAL, Patricio
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: The feeding behaviour of larvae of four Clupeiform fish species (Sardinops sagax, Strangomera bentincki,
 Ethmidium maculatum and Engraulis ringens) was studied using specimens collected from September to November 1987
 in Concepcion Bay, Chile. The indices of food preference (α) of Chesson, of diet overlap (D) of Schoener and (L) of
 Hurlbert, were used. Similar feeding patterns were found in the larvae of the four species. The diet included several
 developmental stages of copepods: eggs, nauplii and copepodites. The larvae of Engraulis ringens showed an early
 euriphagy. There were no significant differences in food preference between the species, except for Ethmidium maculatum,
 which showed a high preference for eggs, even at larger larval sizes. A general trend for preference for larger prey as larvae
 grow is displayed by the other species. No significant difference was found between sampling periods. A high level of diet
 overlap was found, regardless of the index used to estimate it.
Inactivation of NuRD Component Mta2 Causes Abnormal T Cell Activation and Lupus-like Autoimmune Disease in Mice
Creators: name: Kovalev, Grigoriy I.
name: Mishra, Nilamadhab
name: Lu, Xiangdong
name: Ruiz, Phillip
name: Su, Lishan
name: Xia, Li
name: Zhang, Yi
name: Li, En
name: Chang, Hua
name: Knudsen, Geoffrey
name: Kallin, Eric
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Dynamic changes in chromatin structure through ATP-dependent remodeling and covalent modifications on histones play important roles in transcription regulation. Among the many chromatin modifiers identified, the NuRD (nucleosome remodeling histone deacetylase) complex is unique because it possesses both nucleosome remodeling and histone deacetylase activities. To understand the biological function of the NuRD complex, we generated a knock-out mouse model of the Mta2 (metastasis-associated protein 2) gene, which encodes a NuRD-specific component. Mta2 null mice exhibited partial embryonic lethality. The surviving mice developed lupus-like autoimmune symptoms including skin lesions, bodyweight loss, glomerulonephritis, liver inflammation, and production of autoantibodies. Transplantation of bone marrow cells from Mta2 null mice recapitulated some of the symptoms including skin lesion and bodyweight loss in the recipient mice. Mta2 null T lymphocytes showed normal development but hyperproliferation upon stimulation, which correlates with hyperinduction of interleukin (IL)-2, IL-4, and interferon (IFN)-γ. T cell hyperproliferation, but not other autoimmune symptoms, was observed in T cell-specific Mta2 knock-out mice. Mta2 null T cells produced more IL-4 and IFN-γ under Th2 activation conditions, but normal levels of IL-4 and IFN-γ under Th1 activation conditions. Furthermore, we found that IL-4 is a direct target gene of Mta2. Our study suggests that Mta2/NuRD is involved in modulating IL-4 and IFN-γ expression in T cell immune responses, and gene expression in non-T cells plays an important role in controlling autoimmunity.
Dyonic ISO(7) supergravity and the duality hierarchy
Creators: name: Guarino, Adolfo
name: Varela, Oscar
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Motivated by its well defined higher dimensional origin, a detailed study of $D=4$ $\mathcal{N}=8$ supergravity with a dyonically gauged $\textrm{ISO}(7) = \textrm{SO}(7) \ltimes \mathbb{R}^7$ gauge group is performed. We write down the Lagrangian and describe the tensor and duality hierarchies, focusing on an interesting subsector with closed field equations and supersymmetry transformations. We then truncate the $\mathcal{N}=8$ theory to some smaller sectors with $\mathcal{N}=2$ and $\mathcal{N}=1$ supersymmetry and SU(3), $\textrm{G}_2$ and SO(4) bosonic symmetry. Canonical and superpotential formulations for these sectors are given, and their vacuum structure and spectra is analysed. Unlike the purely electric ISO(7) gauging, the dyonic gauging displays a rich structure of vacua, all of them AdS. We recover all previously known ones and find a new $\mathcal{N}=1$ vacuum with SU(3) symmetry and various non-supersymmetric vacua, all of them stable within the full $\mathcal{N}=8$ theory.
description: 52 pages, 4 tables. v2: Section 2.4 on critical points added. v3: Version published in JHEP
Mental Health Morbidity in Survivors of Cardiogenic Shock Complicating Myocardial Infarction – A Population-Based Cohort Study
Creators: name: Thiele, Holger
name: Bienvenu, Joseph
name: McIsaac, Daniel I
name: Qureshi, Danial
name: Di Santo, Pietro
name: Scales, Damon
name: Mathew, Rebecca
name: Kwado Kyeremanteng
name: Vigod, Simone
name: Combes, Alain
name: Needham, Dale
name: Tanuseputro, Peter
name: Sterling, Lee
name: Fernando, Shannon
name: Herridge, Margaret
name: Talarico, Robert
name: Van Diepen, Sean
name: Brodie, Daniel
name: Hibbert, Benjamin
name: Price, Susanna
name: Fan, Eddy
name: Slutsky, Arthur
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Cardiology
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Critical Care

description: Population-based cohort study aimed to evaluate the association between survivorship after cardiogenic shock secondary to acute myocardial infarction (AMI-CS), and new mental health diagnoses, self-harm, and suicide.
title: MRI features and clinical outcomes of osteomyelitis-myositis complex
Creators: name: Leung, Bonnie
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal soft tissue
subject: MR
subject: Diagnostic procedure
subject: Infection

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Acute osteomyelitis is an infection of the bone which can be associated with surrounding muscle involvement described as myositis [1]. These musculoskeletal infections can lead to significant morbidity and mortality in our patient population at...
Increased Cellular Free Cholesterol in Macrophage-specific Abca1 Knock-out Mice Enhances Pro-inflammatory Response of Macrophages
Creators: name: Gebre, Abraham K.
name: Lee, Ji Young
name: Timmins, Jenelle M.
name: Boudyguina, Elena
name: Maeda, Nobuyo
name: Mulya, Anny
name: Mishra, Nilamadhab
name: Parks, John S.
name: Brown, J. Mark
name: Zhu, Xuewei
name: Hiltbold, Elizabeth M.
name: Willingham, Mark C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Macrophage-specific Abca1 knock-out (Abca1–M/–M) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate immune response of macrophages. Plasma lipid and lipoprotein concentrations in chow-fed Abca1–M/–M and wild-type (WT) mice were indistinguishable. Compared with WT macrophages, Abca1–M/–M macrophages had a >95% reduction in ABCA1 protein, failed to efflux lipid to apoA-I, and had a significant increase in free cholesterol (FC) and membrane lipid rafts without induction of endoplasmic reticulum stress. Lipopolysaccharide (LPS)-treated Abca1–M/–M macrophages exhibited enhanced expression of pro-inflammatory cytokines and increased activation of the NF-κB and MAPK pathways, which could be diminished by silencing MyD88 or by chemical inhibition of NF-κB or MAPK. In vivo LPS injection also resulted in a higher pro-inflammatory response in Abca1–M/–M mice compared with WT mice. Furthermore, cholesterol depletion of macrophages with methyl-β-cyclodextrin normalized FC content between the two genotypes and their response to LPS; cholesterol repletion of macrophages resulted in increased cellular FC accumulation and enhanced cellular response to LPS. Our results suggest that macrophage ABCA1 expression may protect against atherosclerosis by facilitating the net removal of excess lipid from macrophages and dampening pro-inflammatory MyD88-dependent signaling pathways by reduction of cell membrane FC and lipid raft content.
Growth of marine bacterioplankton on river and seawater dissolved organic carbon in a Mediterranean coastal system
Creators: name: KORMAS, Konstantinos Ar.
name: PAPASPYROU, Sokratis
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: The growth of marine bacteria and the degradation of bulk river and seawater dissolved organic carbon (DOC)
 were investigated in a coastal system of the Aegean Sea, Eastern Mediterranean. Batch cultures were set up for each season
 under study (summer to winter) and incubated at in situ temperature. Changes in inorganic nutrients and DOC
 concentrations, bacterial abundance and biomass were monitored for a maximum of ca. 17 days. Bacterial specific growth
 rate (µ) ranged between 0.011 – 0.023 h-1 in the river water cultures and between 0.012 - 0.022 h-1 in the seawater cultures.
 In most cases, bacterial abundance, bacterial productivity (BP) and bacterial growth efficiency (BGE) were higher in the
 river water cultures than in the seawater ones. However, on average, marine utilizable DOC (UDOC) was higher (42.2%)
 than the riverine UDOC (38.7%). Inorganic nutrients seemed not to be limiting for bacterial growth and in most of the
 incubations final nitrogen and phosphorous concentrations were similar or higher than the initial ones. Temperature did not
 correlate with any of the bacterial parameters but it correlated positively with DOC degradation rates in both treatments,
 suggesting that temperature had no direct effect on bacterial growth on either riverine or marine DOC.
title: Imaging findings of acute and chronic cholecystitis
Creators: name: Lim, Joel
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Biliary Tract / Gallbladder
subject: Abdomen
subject: Gastrointestinal tract
subject: CT
subject: Ultrasound
subject: MR
subject: Cholangiography
subject: Education
subject: Calcifications / Calculi
subject: Education and training

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To illustrate and describe the findings of acute and chronic cholecystitis, highlighting the complementary role of Ultrasound (US) and Computed Tomography (CT). To illustrate complications of acute cholecystitis namely gangrenous...
(4045) Robert Cree
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
LA SATIRA SECENTESCA: MODI, FORME, QUESTIONI
Creators: name: ALONZO, GIUSEPPE
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: The aim of the dissertation is to offer a modern monograph on the seventeenth-century satirical genre, starting from a theoretical perspective and enriching it through a specific examination of the historical developments and structural constants of the genre. The thesis is divided into three sections, the first (Introduction to the seventeenth-century satire) offers a historical overview of the developments of this kind of satire, and its delineation well in the determination of the corpus examined. The second (Metasatire) is strictly theoretical, and is intended to illustrate the statute of such seventeenth-century satire through the drawing up that is provided by the satirists themselves, whose metaliterary sections included in satires are examined, or side works aimed at a general speculation. The third section (Narration) is ultimately of a structural nature, since it aims, on several levels, to illustrate the narrative strategies that feed the seventeenth-century satirical genre, relying on the main narratological categories and moving from the distinction between the authorial personality of the writer and the literary figure of a moral satirist-narrator who says ?I?.
(4047) Sophia Roederer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Telescope performance and image simulations of the balloon-borne coded-mask protoMIRAX experiment
Creators: name: Penacchioni, A. V.
name: Braga, J.
name: Castro, M. A.
name: D'Amico, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this work we present the results of imaging simulations performed with the help of the GEANT4 package for the protoMIRAX hard X-ray balloon experiment. The instrumental background was simulated taking into account the various radiation components and their angular dependence, as well as a detailed mass model of the experiment. We modeled the meridian transits of the Crab Nebula and the Galatic Centre region during balloon flights in Brazil ($\sim -23^{\circ}$ of latitude and an altitude of $\sim 40 \thinspace$ km) and introduced the correspondent spectra as inputs to the imaging simulations. We present images of the Crab and of three sources in the Galactic Centre region: 1E 1740.7-2942, GRS 1758-258 and GX 1+4. The results show that the protoMIRAX experiment is capable of making spectral and timing observations of bright hard X-ray sources as well as important imaging demonstrations that will contribute to the design of the MIRAX satellite mission.
description: 9 figures
Unicit� du monde et figures de la temporalit� chez Marsile Ficin avec introduction, pr�sentation, �tablissement critique du text, traduction, notes et commentaire des Argumenta Marsilii Ficinii in Rempublicam Platonis
Creators: name: ROCHE GRANDPIERRE, ELISABETH
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: The thesis studies and highlights the central theme of temporality in Marsilio Ficino?s philosophy which is a thought crossed by the figures of time that are tradition, revelation and hope. The philosophy of Ficino, which is both a coherent and united thought, is not a system but it is rather the expression of a dynamic, specific to the Renaissance thought. In this study, the forms of the temporality and the unicity of the world are examined through the critical analysis of Marsilio Ficino's Commentary on the Republic of Plato which, unlike the political and ethical themes specific to the platonic dialogue, is expressly metaphysical and theological because the figures of temporality are conceived as so many metaphysical points of view from which are contemplated the world and the beings composing it. As this text did not benefit from a modern French translation, the thesis fills a gap in ficinian studies by proposing for the first time a French translation of the Argumenta in Rempublicam Platonis is proposed for the first time and, this French version, which is based on the critical establishment of the text, includes a notice, additional notes and the possibility of referring to the various sources on which this work is based. Finally, the thesis exposes a strictly ficinian definition of temporality as a spiritual and human reality by dealing with the question of the genesis and genealogy of temporal concepts and showing its cosmological implication.
Insulin-like Growth Factor-I Stimulates Shc-dependent Phosphatidylinositol 3-Kinase Activation via Grb2-associated p85 in Vascular Smooth Muscle Cells
Creators: name: Clemmons, David R.
name: Radhakrishnan, Yashwanth
name: Ling, Yan
name: Maile, Laura A.
name: Graves, Lee M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Insulin-like growth factor-I (IGF-I) stimulates vascular smooth muscle cell proliferation and migration by activating both MAPK and phosphatidylinositol 3-kinase (PI3K). Vascular smooth muscle cells (VSMCs) maintained in 25 mm glucose sustain MAPK activation via increased Shc phosphorylation and Grb2 association resulting in an enhanced mitogenic response compared with cells grown in 5 mm glucose. PI3K plays a major role in IGF-I-stimulated VSMC migration, and hyperglycemia augments this response. In contrast to MAPK activation the role of Shc in modulating PI3K in response to IGF-I has not been determined. In this study we show that impaired Shc association with Grb2 results in decreased Grb2-p85 association, SHPS-1-p85 recruitment, and PI3K activation in response to IGF-I. Exposure of VSMCs to cell-permeable peptides, which contained polyproline sequences from p85 proposed to mediate Grb2 association, resulted in inhibition of Grb2-p85 binding and AKT phosphorylation. Transfected cells that expressed p85 mutant that had specific prolines mutated to alanines resulted in less Grb2-p85 association, and a Grb2 mutant (W36A/W193A) that attenuated p85 binding showed decreased association of p85 with SHPS-1, PI3K activation, AKT phosphorylation, cell proliferation, and migration in response to IGF-I. Cellular exposure to 25 mm glucose, which is required for Shc phosphorylation in response to IGF-I, resulted in enhanced Grb2 binding to p85, activation of PI3K activity, and increased AKT phosphorylation as compared with cells exposed to 5 mm glucose. We conclude that in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration.
title: Distended gastrocnemius bursae/recesses: Clinical significance and associated findings on MRI
Creators: name: Moore, Timothy
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal soft tissue
subject: MR
subject: Diagnostic procedure
subject: Cysts

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Fluid-filled collections adjacent to the tendons of origin of the medial and lateral heads of gastrocnemius are frequent findings on routine knee MRI studies. Often noted, but rarely reported, these collections are usually regarded as...
(4048) Maria Vincent
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Interaction with the 5D3 Monoclonal Antibody Is Regulated by Intramolecular Rearrangements but Not by Covalent Dimer Formation of the Human ABCG2 Multidrug Transporter
Creators: name: Hegedus, Csilla
name: Litman, Thomas
name: Laczko, Rozália
name: Goda, Katalin
name: Dokholyan, Nikolay V.
name: Sorrentino, Brian P.
name: Váradi, András
name: Hegedus, Tamás
name: Sarkadi, Balázs
name: Özvegy-Laczka, Csilla
name: Várady, György
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Human ABCG2 is a plasma membrane glycoprotein working as a homodimer or homo-oligomer. The protein plays an important role in the protection/detoxification of various tissues and may also be responsible for the multidrug-resistant phenotype of cancer cells. In our previous study we found that the 5D3 monoclonal antibody shows a function-dependent reactivity to an extracellular epitope of the ABCG2 transporter. In the current experiments we have further characterized the 5D3-ABCG2 interaction. The effect of chemical cross-linking and the modulation of extracellular S–S bridges on the transporter function and 5D3 reactivity of ABCG2 were investigated in depth. We found that several protein cross-linkers greatly increased 5D3 labeling in ABCG2 expressing HEK cells; however, there was no correlation between covalent dimer formation, the inhibition of transport activity, and the increase in 5D3 binding. Dithiothreitol treatment, which reduced the extracellular S–S bridge-forming cysteines of ABCG2, had no effect on transport function but caused a significant decrease in 5D3 binding. When analyzing ABCG2 mutants carrying Cys-to-Ala changes in the extracellular loop, we found that the mutant C603A (lacking the intermolecular S–S bond) showed comparable transport activity and 5D3 reactivity to the wild-type ABCG2. However, disruption of the intramolecular S–S bridge (in C592A, C608A, or C592A/C608A mutants) in this loop abolished 5D3 binding, whereas the function of the protein was preserved. Based on these results and ab initio folding simulations, we propose a model for the large extracellular loop of the ABCG2 protein.
(4044) William James Cree
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Scale-invariant power spectra from a Weyl-invariant scalar-tensor theory
Creators: name: Myung, Yun Soo
name: Park, Young-Jai
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We obtain scale-invariant scalar and tensor power spectra from a Weyl-invariant scalar-tensor theory in de Sitter spacetime. This implies that the Weyl-invariance guarantees to implement the scale-invariance of power spectrum in de Sitter spacetime. We establish a deep connection between the Weyl-invariance of the action and scale-invariance of power spectrum in de Sitter spacetime.
description: 19 pages, no figures, version to appear in EPJC. arXiv admin note: text overlap with arXiv:1407.0441
Colorblind ideology/Assimilation and Perception of a Bleak Future on Anti-immigration attitudes and White Nationalism: Replication and Extensions
Creators: name: Christine E Reyna, Ph.D.
name: Sulaimon Kasali
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social Psychology
subject: Social Psychology and Interaction
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology
subject: anti-immigrant policies
subject: assimilation
subject: colorblind ideology
subject: extremism
subject: perceived bleak future
subject: prejudice
subject: white nationalism

description: In our first pre-registered study titled “Re-categorization and Perception of a Bleak Future”, we assess whether (1) the perception of a bleak future for one’s racial group by the majority (Whites) will predict anti-immigration policies, (2) not recategorizing targets of prejudice as having a shared identity will lead Whites to show higher anti-immigration attitudes, especially when they perceive a bleak future. Our analysis showed that anti-immigration attitudes were not dependent on recategorizations, i.e participants who recategorized and those who did not showed higher anti-immigration attitudes when they perceived a bleak future. However, the trend for low recategorizers was more steep than for the high recatgeorizers. Hence, the effect of perceived bleak future on anti-immigration attitudes was more pronounced in low recategorizers. In our previous study, we acknowledge that the item we used to measure recategorization was actually a measure of assimilation (a facet of colorblindness) which explains the result. Therefore, the purpose of this research is to see if the result found in our earlier study would replicate using explicit measures of color blind ideology (CBI)/assimilation. We expect a similar pattern with support for white nationalist ideologies.
TITLE: 'REGULATORY MECHANISMS IN TUMORIGENESIS'. SUBTITLE: 'THE DOWNREGULATION OF HOXA2 GENE IN BREAST CANCERS'.
Creators: name: DE PALMA, FATIMA DOMENICA ELISA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Breast cancer (BC) is a heterogeneous group of diseases, each one characterized by different biological, molecular and clinical features. Accumulating evidences indicated the currently promising role of genetic and epigenetic subtype-specific biomarkers for BC early detection and disease monitoring. HOXA2, a member of the HOX gene family, is a transcription factor involved in gene expression regulation during embryonic development. Dysregulation of HOXA2 expression has been associated with different cancers. However, limited information is available on HOXA2 expression and functions in breast tumorigenesis. Here, we have demonstrated that HOXA2 is significantly downregulated in human BC tissues and cell lines. Immunohistochemistry and survival curve analysis showed a significant negative correlation between the downexpression of HOXA2 and histological grading, tumor stage and lymph node involvement, and relapse-free survival in hormone positive BC patients, respectively. At functional level, we demonstrated that HOXA2-knockdown significantly enhances cell proliferation, cell migration and invasion. In contrast, HOXA2 increased expression induced by HOXA2-overespression remarkably inhibits cell proliferation. In conclusion, our data provide evidence that HOXA2 is a tumor suppressor gene, whose downregulation is implicated in BC progression and predicts poor relapse-free survival rate in BC patients.
The Idea of Fear as Reflected in Shaw’s Saint Joan
Creators: name: Muzahim Ali alkareem, khawla
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 470504
subject: British and Irish literature

description: One of the major themes that Shaw explores in his works is the concept of fear and terror. Fear of revolution or reformation takes precedence over all other fears in his plays . This paper shows how Shaw tackled this recurring idea of fear from change, reformation, and revolution. It reflects Shaw’s philosophy that the essence of our changing human world is revolution and reformation. As a result, there are anti-revolutionary forces that are afraid of such revolutionary figures. For the sake of truth and social reformation, reformists do their best and even risk their lives. Joan of Arc, a historical heroine, is used by Shaw as a symbol of reformation and revolution. Those who dread such people, on the other hand, do everything they can to prevent people from using their sacred right to revolt against tyranny and injustice. The paper focuses on Saint Joan as Shaw's best work that deals with the fear of reformation.
THE AXIAL SYMMETRY OF SPONGE SPICULES AND ITS PHYLOGENETIC SIGNIFICANCE
Creators: name: REISWIG, Henry M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Axial canals and thus presumably axial filaments of all Hexactinellida surveyed are square in cross section. Axial canals and filaments of Demospongiae, where resolvable by light microscopy, are triangular in cross section. This includes the majority of samples studied in the orders Choristida. Spirophorida, Hadromerida, Axinellida, and Poecilosclerida. The canals of the Homoscleropho- rida, Haplosclerida, and Halichondrida are generally too small to resolve by light microscopy. The relationship of secondary axes to the symmetry of the primary axial filament indicates that the shape of the primary filament may reflect the potential limits of external spicule symmetry. The basic potential symmetry of the axis may or may not be expressed in external spicule morphology. The presence of triangular axial canals in both subclasses, Tetractinomorpha and Ceractinomorpha, as proposed by Levi, indicates a close relationship between the two goups. The independent evolution of spicules in these two subclasses of demosponges as suggested by Lévi and Reid is rejected by the results of this study. Discontinuities in the taxonomic placements of several species and genera of demosponges, indicated in the work of previous authors, are re-emphasized by differences in the ability or inability to resolve a triangular axial canal with light microscopy in these cases.
Additional file 1 of Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC
Creators: name: Li, Jie-pin
name: Liu, Yuan-jie
name: Zeng, Shu-hong
name: Gao, Hai-jian
name: Chen, Yu-gen
name: Zou, Xi
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Table S1. Figure S1. Figure S2. Figure S3. Figure S4. Figure S5. Figure S6.
Gravitational waves from Sco X-1: A comparison of search methods and prospects for detection with advanced detectors
Creators: name: Messenger, C.
name: Bulten, H. J.
name: Crowder, S. G.
name: Dergachev, V.
name: Galloway, D. K.
name: Goetz, E.
name: Jonker, R. J. G.
name: Lasky, P. D.
name: Meadors, G. D.
name: Melatos, A.
name: Premachandra, S.
name: Riles, K.
name: Sammut, L.
name: Thrane, E. H.
name: Whelan, J. T.
name: Zhang, Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The low-mass X-ray binary Scorpius X-1 (Sco X-1) is potentially the most luminous source of continuous gravitational-wave radiation for interferometers such as LIGO and Virgo. For low-mass X-ray binaries this radiation would be sustained by active accretion of matter from its binary companion. With the Advanced Detector Era fast approaching, work is underway to develop an array of robust tools for maximizing the science and detection potential of Sco X-1. We describe the plans and progress of a project designed to compare the numerous independent search algorithms currently available. We employ a mock-data challenge in which the search pipelines are tested for their relative proficiencies in parameter estimation, computational efficiency, robust- ness, and most importantly, search sensitivity. The mock-data challenge data contains an ensemble of 50 Scorpius X-1 (Sco X-1) type signals, simulated within a frequency band of 50-1500 Hz. Simulated detector noise was generated assuming the expected best strain sensitivity of Advanced LIGO and Advanced VIRGO ($4 \times 10^{-24}$ Hz$^{-1/2}$). A distribution of signal amplitudes was then chosen so as to allow a useful comparison of search methodologies. A factor of 2 in strain separates the quietest detected signal, at $6.8 \times 10^{-26}$ strain, from the torque-balance limit at a spin frequency of 300 Hz, although this limit could range from $1.2 \times 10^{-25}$ (25 Hz) to $2.2 \times 10^{-26}$ (750 Hz) depending on the unknown frequency of Sco X-1. With future improvements to the search algorithms and using advanced detector data, our expectations for probing below the theoretical torque-balance strain limit are optimistic.
description: 33 pages, 11 figures
title: A Diagnostic Imaging Algorithm for Developmental Dysplasia of the Hip
Creators: name: Shivananda, Arjun
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Paediatric
subject: Ultrasound
subject: Plain radiographic studies
subject: Education
subject: Developmental disease

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Developmental dysplasia of the hip (DDH) is the most common hip pathology noted in infants and delayed diagnosis may lead to early development of osteoarthritis in addition to gait abnormalities. [1] The screening of children for DDH is a...
NUCLEAR FRAGMENTATION CROSS SECTIONS MEASUREMENTS FOR HADRONTHERAPY: IMPLEMENTATION AND OPTIMIZATION OF A BEAM MONITORING SYSTEM
Creators: name: DONG, YUNSHENG
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: The FOOT project is a nuclear physics experiment that aims to measure the differential cross sections (d2?/d?�dE) of the nuclear interactions involved in particle therapy and space radioprotection. The final experimental data will be adopted as benchmark for the MC simulation tools, to improve the current particle therapy treatment planning systems and to develop a new shielding design suitable for the future space missions. The FOOT project consists of two different experimental setups and in both of them a drift chamber is adopted as Beam Monitor to measure the projectile direction and position, to count the total number of delivered particles and to reject the pre-target fragmentation events. In this Ph. D. project, which has contributed to the construction and start of the FOOT experiment, the drift chamber has been finalized, tested, calibrated and operated in the experiment. A multi-track reconstruction algorithm has been developed taking advantages of the Legendre transformation properties combined with a ?2 minimization algorithm. The software has been tested and optimized both on experimental and on MC simulated data and it has been included within the FOOT global reconstruction code. The detector has been used in different tests and data takings. In particular, an extensive calibration and performance assessment has been conducted with protons at 228 and 80 MeV. In this occasion, the overall Beam Monitor efficiency, spatial resolution and active area have been measured. In addition, the space-time relations of the drift chamber have been measured and the results have been adopted as benchmark for a self calibration method developed to estimate the space-time relations using only the Beam Monitor hits and tracks. The detector has been successfully operated in the FOOT data takings performed with both the experimental setups. In particular, in the framework of the emulsion spectrometer measurements, the Beam Monitor has been employed to measure the profile of the irradiation pattern and to count the total number of delivered particles. Then, during the test performed with the electronic spectrometer, the drift chamber has been used with the FOOT general DAQ system to measure the incoming beam direction and position. In addition, the Beam Monitor has performed a characterization of the GSI 700 MeV/u carbon ion beam, measuring the transverse spot size, the rate and the angular spread of the incoming beam. The final part of the project has been devoted to a detailed study of the performances of the detector in view of the work for the data analysis of the FOOT experiment. In particular, different selection criteria have been studied to identify and reject the pre-target fragmentation events and the impact of the drift chamber spatial resolution on the cross section accuracy has been estimated by means of MC simulations.
Epidemiology of gnathiid isopods on red mullet (Mullus barbatus barbatus) along the Tyrrhenian Sicilian coast (Mediterranean Sea)
Creators: name: BOTTARI, Teresa
name: RINELLI, Paola
name: GAROFALO, Germana
name: SPANÒ, Nunziacarla
name: MANGANO, Maria C.
name: PORPORATO, Erika M.D.
name: MOBILIA, Valeria
name: FIORENTINO, Fabio
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Fishing, reducing the density of fish, might decrease the efficiency of parasite transmission. The present study aims at examining the presence of gnathiid isopods on a wild fish species, the red mullet, under the influence of trawling activity by comparing epidemiological data of trawled and no-trawled areas. The potential impact of gnathiids on the red mullet within a no-trawled area (NTA) of the Southern Tyrrhenian Sea (Central Mediterranean Sea) has been assessed examining epidemiological indices in relation to season, sex, age and host condition. The spatial distribution of prevalence in the study was heterogeneous with the bulk of gnathiids found inside the NTA. Similarly, the intensity and abundance showed values significantly higher inside the NTA than outside. Inside the NTA temporal variations of gnathiid infestation were evident, with the lowest prevalence and intensity during winter but without a seasonal pattern. Gnathiids infection is not related to the sex and age of the red mullet and does not influence negatively the host condition. The occurrence of gnathiids, despite being temporary and generalist parasites, strongly reflects the host density and site protection level.
title: Assessment of a small-animal IGRT device for pre-clinical radiotherapy research
Creators: name: Ebert, Martin
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Oncology
subject: Radiation physics
subject: CT-High Resolution
subject: Experimental
subject: Equipment
subject: Experimental investigations
subject: Radiobiology
subject: Cancer
subject: Radiotherapy techniques

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Pre-clinical radiotherapy research can be impeded due to poor replication of clinical treatments in animal models. Small-animal radiotherapy devices (SARDs) ‘scale-down’ the geometry of a clinical linear accelerator to the scale of a mouse or...
Leukocyte Antigen-related Protein Tyrosine Phosphatase Negatively Regulates Hydrogen Peroxide-induced Vascular Smooth Muscle Cell Apoptosis
Creators: name: Madamanchi, Nageswara R.
name: Niu, Xi Lin
name: Li, Juxiang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Reactive oxygen species (ROS) have been implicated in vascular smooth muscle cell (VSMC) apoptosis, a hallmark of advanced atherosclerotic lesions. Transient oxidation and inactivation of protein-tyrosine phosphatases play a critical role in cellular response to ROS production. However, the function of leukocyte antigen-related (LAR) protein-tyrosine phosphatase in ROS signaling is not known. To determine the expression of LAR in ROS-induced apoptosis, we investigated hydrogen peroxide-induced cell death and signaling in aortic VSMCs from wild-type and LAR-/- mice. Histone-associated DNA fragmentation and caspase-3/7 activity were significantly enhanced, mitochondrial membrane integrity was compromised, and cell viability was significantly decreased following H2O2 treatment in LAR-/- VSMCs compared with wild-type cells. Stronger and sustained increase in autophosphorylation and activity of Fyn, an Src family tyrosine kinase, was observed in LAR-/- cells compared with wild-type cells following H2O2 treatment. LAR binds to activated Fyn in H2O2-treated VSMCs, and recombinant LAR dephosphorylates phosphorylated-Fyn in vitro. In addition, LAR deficiency enhanced H2O2-induced phosphorylation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), and p38 mitogen-activated protein kinase (MAPK). PP2, a Fyn-specific inhibitor, blocked JAK2, STAT3, and p38 MAPK activation and significantly attenuated apoptosis induced by H2O2. AG490, a JAK2-specific inhibitor, significantly attenuated H2O2-induced apoptosis, and blocked H2O2-induced activation of STAT3, but not p38 MAPK in both wild-type and LAR-/- VSMCs. Attenuation of Fyn expression by short hairpin RNA significantly decreased H2O2-induced downstream signaling and apoptosis in VSMCs. Together, these data indicate that LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis.
TAXATION OF CROSS-BORDER SERVICES IN THE CURRENT INTERNATIONAL, EUROPEAN AND ITALIAN CONTEXT
Creators: name: SUT, SILVIA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: The PhD thesis is entitled to the study of the rules concerning the taxation of services in the International, European and Italian context. The decision to study the taxation of services stems from the prominent position of these activities in today?s economy: such a consideration applies both to developed countries, as well as to developing countries. Such prominence position has been further intensified by the digital revolution. Because of this even more ?service ? oriented? structure, the taxation of services has been under scrutiny for at least thirty years: lately this issue has been brought to the forefront of international taxation debate, in relation to which the taxation of services appears to be nowadays one of the most controversial topic. The work is structured in three chapters, which focus on the taxation of cross ? border services in the current international tax system (chapter 1), on the taxation of cross ? border intra group services in light of its main transfer pricing implications (chapter 2) and on the taxation of digital cross ? border services (chapter 3). Each of the three mentioned chapters starts with an introductory question, followed by the analysis of the main aspects related to the International and European frameworks. The domestic level is also considered: those domestic frameworks that appear to be of most interest for the analysis performed in each chapter have been indeed selected. The last chapter 4 discusses the conclusions of the analysis performed in the three preceding chapters in light of the Italian experience, the one which the PhD student is most familiar with.
title: Correlation of arthritis severity with incidence of falls - An MRI evaluation study.
Creators: name: Rozalli, Faizatul Izza
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal joint
subject: MR
subject: Comparative studies
subject: Arthritides

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Numerous factors contribute to the risk of falling in community-dwelling elderly persons.Falls in older people can cause physical injuries (fractures, head injuries) resulting in disabilities. It can also have long term psychological consequences...
Deterministic separation of suspended particles in a reconfigurable obstacle array
Creators: name: Du, Siqi
name: Drazer, German
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We use a macromodel of a flow-driven deterministic lateral displacement (DLD) microfluidic system to investigate conditions leading to size-separation of suspended particles. This model system can be easily reconfigured to establish an arbitrary orientation between the average flow field and the array of obstacles comprising the stationary phase (forcing angle). We also investigate the effect of obstacle size using two arrays with different obstacles but same surface-to-surface distance between them. In all cases, we observe the presence of a locked mode at small forcing angles, in which particles move along a principal direction in the lattice until a locked-to-zigzag transition takes place when the driving force reaches a critical angle. We show that the transition occurs at increasing angles for larger particles, thus enabling particle separation at specific forcing angles. Moreover, we observe a linear correlation between the critical angle and the size of the particles that could be used in the design of microfluidic systems with a fixed orientation of the flow field. Finally, we present a simple model, based on the presence of irreversible interactions between the suspended particles and the obstacles, which describes the observed dependence of the migration angle on the orientation of the average flow.
title: Thomas Jefferson als Virtuose der Öffentlichkeit? Politiker-Intellektuelle in Nordamerika zur Revolutionszeit
Creators: name: Scheerer, Hanno
Publisher: name: MAP - Modern Academic Publishing, Universität zu Köln
Year: 2016

description: Virtuosen der Öffentlichkeit? Friedrich von Gentz (1764-1832) im globalen intellektuellen Kontext seiner Zeit
Lysyl Oxidase Binds Transforming Growth Factor-β and Regulates Its Signaling via Amine Oxidase Activity
Creators: name: Katafuchi, Michitsuna
name: Yamauchi, Mitsuo
name: Csiszar, Katalin
name: Mochida, Yoshiyuki
name: Fong, Keith S.K.
name: Atsawasuwan, Phimon
name: Kaku, Masaru
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Lysyl oxidase (LOX), an amine oxidase critical for the initiation of collagen and elastin cross-linking, has recently been shown to regulate cellular activities possibly by modulating the functions of growth factors. In this study, we investigated the interaction between LOX and transforming growth factor-β1 (TGF-β1), a potent growth factor abundant in bone, the effect of LOX on TGF-β1 signaling, and its potential mechanism. The specific binding between mature LOX and mature TGF-β1 was demonstrated by immunoprecipitation and glutathione S-transferase pulldown assay in vitro. Both proteins were colocalized in the extracellular matrix in an osteoblastic cell culture system, and the binding complex was identified in the mineral-associated fraction of bone matrix. Furthermore, LOX suppressed TGF-β1-induced Smad3 phosphorylation likely through its amine oxidase activity. The data indicate that LOX binds to mature TGF-β1 and enzymatically regulates its signaling in bone and thus may play an important role in bone maintenance and remodeling.