cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design of coplanar power amplifiers for MM-WAVE system applications including thermal aspects
Creators: name: Bessemoulin, A.
name: Marsetz, W.
name: Baeyens, Y.
name: Osorio, R.
name: Massler, H.
name: Hülsmann, A.
name: Schlechtweg, M.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2000
Subjects: ING-INF/01 Elettronica

description: Due to the poor thermal conductivity of GaAs, successful power amplifier design in coplanar technology requires careful thermal considerations. The influences of the active device geometry and mounting conditions have been investigated theoretically and experimentally to provide reliable thermal management design data. 50-µm thinning and flip-chip with thermal bump attachment on AlN or diamond exhibited temperature rises in the order of 50 and 40-30 °C respectively, leading to significant improvement in the performance of coplanar power devices and circuits. These results demonstrate the potential of coplanar MMIC technology for high power applications.
Eventia: Adaptive Navigation System-Human Following Robot Using Arduino Uno
Creators: name: Shraddha. R. Ratnaparkhi, Atharva.Y.Deshmukh, Pranav. V. Patil, Parth. S. Wawge, Mohammed Saif
Publisher: name: Zenodo
Year: 2025

description: This paper presents the design and implementation of an adaptive navigation system for a humanfollowing robot using Arduino Uno, IR sensors, ultrasonic sensors, a servo motor, DC gear motors, and amotor driver shield. The system is designed to autonomously follow a human while avoiding obstacles inreal-time. The robot uses IR sensors for human detection, ultrasonic sensors for obstacle avoidance, and aservo motor for directional control. The motor driver shield controls the DC gear motors, enabling smoothmovement. The proposed system is cost-effective, easy to implement, and suitable for applications inhealthcare, retail, and personal assistance. Experimental results demonstrate the robot's ability to follow ahuman accurately while navigating through dynamic environments.
Moduli of Abelian varieties, Vinberg theta-groups, and free resolutions
Creators: name: Gruson, Laurent
name: Sam, Steven V
name: Weyman, Jerzy
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: Commutative Algebra (math.AC)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 13D02, 14K05, 15A72, 14L24

description: We present a systematic approach to studying the geometric aspects of Vinberg theta-representations. The main idea is to use the Borel-Weil construction for representations of reductive groups as sections of homogeneous bundles on homogeneous spaces, and then to study degeneracy loci of these vector bundles. Our main technical tool is to use free resolutions as an "enhanced" version of degeneracy loci formulas. We illustrate our approach on several examples and show how they are connected to moduli spaces of Abelian varieties. To make the article accessible to both algebraists and geometers, we also include background material on free resolutions and representation theory.
description: 41 pages, uses tabmac.sty, Dedicated to David Eisenbud on the occasion of his 65th birthday; v2: fixed some typos and added references
Understanding the role of female school principals : an exploratory case study of four female principals in a metropolitan city in China
Creators: name: Li, Bingbing
Publisher: name: University of British Columbia
Year: 2014

description: Women’s school leadership has been discussed for decades in regard to the influence of gender on educational leadership. Discourse on women’s school leadership focuses on unique leadership styles of female school leaders compared with their male counterparts. Literature on women’s leadership is, in most cases, located in an Anglo-American culture, rather than in a broader cultural context. Research on women’s school leadership in developing countries is marginalized. There is a need for researchers to adopt a cross-cultural framework to analyze the intersecting issue of gender, school leadership and cultural experience. This study focuses on the intersection between educational leadership and societal culture as well as organizational culture within which women school principals act in China. The objectives of this study were to: (1) examine how women school principals exert their leadership and their leadership styles in both public schools and private schools; (2) explore the lived experiences of women school principals in China to examine the conflicts and challenges between social goals and practices that seek to promote gender equity and culturally-based and institutionally-based patriarchal forms of domination within schools; (3) provide suggestions for future school leadership education in China for aspiring women school leaders. This research is an exploratory case study of four women school principals in a metropolitan area (Hangzhou, Zhejiang Province) in China. Case study makes it possible to explore the role of gender in female principals’ negotiation within contexts of personal life history, societal and institutional cultural expectations. This study adopted hybrid strategies for collecting data in the pursuit of triangulation. In addition to four semi-structured interviews with four female principals, data were collected by two additional techniques: document analysis and participant observation. Rich meanings were found with regard to how female principals construct and explain their leadership differently based on various experiences. The findings in this study suggest that women’s leadership in China is a dynamic process that varies with social, institutional and cultural contexts. They also suggest that understanding the role of gender in educational leadership without a cross-cultural approach fails to clarify the experiences of female principals in China.
1W/mm GaAs pHEMT for realization of linear power amplifier in the K band.
Creators: name: Hue, X.
name: Rogeaux, E.
name: Cazaux, Jean-Louis
name: Mallet, A.
name: Lapierre, L.
name: Boudart, B.
name: Bonte, B.
name: Crosnier, Y.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2000
Subjects: ING-INF/01 Elettronica

description: The realization and characterization of Al0.22Ga0.78As/In0.22Ga0.78As/GaAs power pHEMT are reported. This structure was optimized to obtain a quasi flat transconductance profile to increase the device linearity near the compression. A maximum single carrier output power higher than 0.8 W/mm for 2 dB compression has been obtained, with more than 30 % power added efficiency and 7.4 dB linear gain at 18.5 GHz. Two tones intermodulation distortion have shown a C/I ratio of 19.9 dBc and 42.3 dBc to the 3 rd and 5 th order respectively, for an input two tones power corresponding to 1 dB compression input power in CW.
Parametric estimation of hidden stochastic model by contrast minimization and deconvolution: application to the Stochastic Volatility Model
Creators: name: Kolei, Salima El
Publisher: name: arXiv
Year: 2012
Subjects: subject: Applications (stat.AP)
subject: Statistical Finance (q-fin.ST)
subject: FOS: Computer and information sciences
subject: FOS: Economics and business

description: We study a new parametric approach for particular hidden stochastic models such as the Stochastic Volatility model. This method is based on contrast minimization and deconvolution. After proving consistency and asymptotic normality of the estimation leading to asymptotic confidence intervals, we provide a thorough numerical study, which compares most of the classical methods that are used in practice (Quasi Maximum Likelihood estimator, Simulated Expectation Maximization Likelihood estimator and Bayesian estimators). We prove that our estimator clearly outperforms the Maximum Likelihood Estimator in term of computing time, but also most of the other methods. We also show that this contrast method is the most robust with respect to non Gaussianity of the error and also does not need any tuning parameter.
description: 46 pages
Robust rapid-setting antibacterial liquid bandages
Creators: name: Bastos, Carlos A. P.
name: Thom, William D.
name: Reilly, Beth
name: Batalha, Iris L.
name: Burge Rogers, Maedee L.
name: McCrone, Ian S.
name: Faria, Nuno
name: Powell, Jonathan J.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/639/638/298/54/990
/692/308/575
article

description: Abstract: Bandaging is a steadfast but time-consuming component of wound care with limited technical advancements to date. Bandages must be changed and infection risk managed. Rapid-set liquid bandages are efficient alternatives but lack durability or inherent infection control. We show here that antibacterial zinc (Zn) and copper (Cu) species greatly enhance the barrier properties of the natural, waterproof, bio-adhesive polymer, shellac. The material demonstrated marked antibacterial contact properties and, in ex-vivo studies, effectively locked-in pre-applied therapeutics. When challenged in vivo with the polybacterial bovine wound infection ‘digital dermatitis’, Zn/Cu-shellac adhered rapidly and robustly over pre-applied antibiotic. The bandage self-degraded, appropriately, over 7 days despite extreme conditions (faecal slurry). Treatment was well-tolerated and clinical improvement was observed in animal mobility. This new class of bandage has promise for challenging topical situations in humans and other animals, especially away from controlled, sterile clinical settings where wounds urgently require protection from environmental and bacterial contamination.
Synthese und biologische Evaluierung von Verbindungen zur potentiellen Therapie neurodegenerativer Erkrankungen
Creators: name: Barthel, Alexander
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2006
Subjects: subject: Elektronische Publikation
subject: Hochschulschrift
subject: Online-Publikation
subject: Zsfassung in engl. Sprache
subject: 616.8

description: Neurodegenerative Erkrankungen sind eine Gruppe von meist langsam voranschreitender erblicher oder sporadisch auftretender Erkrankungen des zentralen Nervensystems. Zu dieser Gruppe gehören die Prionen- und Alzheimer-Erkankungen, beide sind durch die Ablagerung von Proteinen gekennzeichnet. Durch eine Vielzahl von Untersuchungen konnte die Wirksamkeit von Acridin-Verbindungen bei Prionen-Aggregaten nachgewiesen werden. Dabei zeigten Bis-Acridine, die über einen Spacer verknüpft sind, eine deutlich höhere Aktivität als monomere Derivate. Die größten Aktivitäten wurden bei Verbindungen mit 1,4-Bis-(3-aminopropyl)-piperazin als Spacer beobachtet. In der Arbeit wurde dieses Konzept der dimeren Verbindungen weiter ausgebaut, wobei verschiedene Heterocyclen über einen Piperazin-Spacer verknüpft wurden. Als Heterocyclen wurden Acridine, Phenanthridine, Kastellpaolitine, Isoalloxazine, Purine, Anthrachinone, Chinazolin-2-one, Diazepame und Adamantane verwendet. Des Weiteren erfolgte die Synthese dimerer Acridin-Verbindungen, bei denen die Spacer- Länge variiert und durch die Verwendung von Aminosäuren eine Seitenkette eingeführt wurde. Darüber hinaus wurde der Piperazin-Ring durch Homopiperazin und 5,5-Diethylbarbitursäure ersetzt. Die Aktivitätsbestimmung in Bezug auf eine Anti-Prionen- und eine Anti-Alzheimer-Wirkung erfolgte auf der Basis von FACS-Analysen.
description: Neurodegenerative diseases are a group of mostly slow proceeding or sporadically occurring diseases of the central nervous system. To this groups belong the Alzheimer- as well as prion-based diseases, both of these are characterized by the deposition of proteins. These neuronal plaques cause apoptosis of the surrounding neurons, finally leading to a degeneration of the central nervous system. Several studies showed a potency of acridine-compounds. Dimeric acridine compounds however, that are linked by a spacer, show an increased activity as compared to the monomeric derivatives. The highest activities were observed for compounds containing a 1,4-Bis-(3-aminopropyl)piperazine spacer. In this work the concept of the dimeric compounds was further developed. Different heterocycles were connected by a piperazin spacer. As heterocycles were used acridines, phenanthridines, kastellpaolitines, isoalloxazines, purines, anthraquinones, quinazolin-2-ones, diazepames and adamantanes. Furthermore the synthesis of dimeric acridine compounds was achieved, wherein the length of the spacer was varied and an additional side chain was introduced by the use of amino acids. In addition, the piperazine ring was replaced by homopiperazine or a 5,5-diethylbarbituric acid moiety. The screening of the substances for a antiprion or a antialzheimer activity was performed by FACS analysis.
Finanziarizzazione e regolazione del lavoro: un’alternativa analitica alle vulgate del postfordismo
Creators: name: Salento, Angelo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: IUS/07 Diritto del lavoro
SECS-P/08 Economia e gestione delle imprese
SPS/09 Sociologia dei processi economici e del lavoro
SPS/12 Sociologia giuridica, della devianza e mutamento sociale

description: The goal of this paper is to provide a contribution to the debate concerning the relationship between the financialization process of the economy and the organizational changes implemented by enterprises, as well as the transformation of labour regulation. The hypothesis here proposed is that there is a tight connection between these elements, and that the analysis of such connection provides key insights about how to critically interpret the development, in the last few decades, of organizational and managerial practices and of a profoundly renewed labour law. In this perspective, the paper offers an alternative reconstruction of the so-called “post-fordist” transformations.
190220 Earth Compact 2020
Creators: name: Brenneman, Kurt
Publisher: name: Zenodo
Year: 2019
Subjects: law
international law
government
governance
access
accountability
due process
human rights
ecology
economics
environment
sustainability
earth
compact

description: Earth Compact 2020 is an open source project intended to evolve from a visionary document in 2020 into a fully peer-to-peer Earth Compact, living on in perpetuity as an open source universal agreement on certain immutable elements of the rule of law necessary to governance of sustainable human ecology.
Systematische Inaktivierung des murinen 12/15-Lipoxygenase-Gens (Alox15) schützt weibliche Mäuse vor einer durch Dextran-Natriumsulfat induzierten Kolitis
Creators: name: Kroschwald, Saskia
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2018
Subjects: subject: Dickdarmentzündung
subject: Pathophysiologie
subject: Tierversuch
subject: 616.3447

description: Die 12/15-Lipoxygenase (Alox15) wird häufig als funktioneller Gegenspieler der pro- inflammatorischen 5-Lipoxygenase (Alox5) angesehen, da das Enzym in mehreren Entzündungsmodellen eine anti-inflammatorische Wirkung zeigt. Um zu überprüfen, ob dies auch für die murine Kolitis zutrifft, wurde bei Alox15-defizienten Mäusen und entsprechenden Kontrolltieren eine experimentelle DSS-Kolitis ausgelöst. Dabei erhielten die Tiere über sieben Tage 2,5 % DSS über das Trinkwasser. Dieser Induktionsphase folgte eine sieben-tägige Erholungsphase, während der kein DSS appliziert wurde. Als klinische Parameter für den Schweregrad der Erkrankung galten Gewichtsveränderungen, der Krankheitsaktivitätsindex (DAI) und die Kolonlänge. Weiterhin wurde mithilfe der qRT- PCR im Darmgewebe das Expressionsniveau pro- und anti-inflammatorischer Zytokine (TNFa, IL-1b, TGFb), wichtiger Komponenten der intestinalen Barriere (Occludin, Claudin- 1, Kollagen IV) sowie pro-inflammatorischer Enzyme (COX1, COX2, iNOS) quantifiziert. Ex vivo-Experimente zur intestinalen Permeabilität sollten zum besseren Verständnis der pathophysiologischen Prozesse beitragen, die der DSS-Kolitis zugrunde liegen. Die Alox15-defizienten Mäuse waren im Vergleich zu den Wildtyptieren gegenüber der induzierten DSS-Kolitis geschützt. Die molekularen Ursachen für diesen Zusammenhang sind noch nicht eindeutig geklärt. Die mechanistischen Untersuchungen dieser Arbeit deuten darauf hin, dass die Erhöhung der intestinalen Permeabilität bei den Alox15- defizienten Mäusen im Vergleich zu den Wildtyptieren weniger stark ausgeprägt ist. Diese Hypothese wird durch Expressionsstudien von Tight Junction-Proteinen bestätigt.
Maximum-likelihood estimation of lithospheric flexural rigidity, initial-loading fraction, and load correlation, under isotropy
Creators: name: Simons, Frederik J.
name: Olhede, Sofia C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Geophysics (physics.geo-ph)
subject: Statistics Theory (math.ST)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Topography and gravity are geophysical fields whose joint statistical structure derives from interface-loading processes modulated by the underlying mechanics of isostatic and flexural compensation in the shallow lithosphere. Under this dual statistical-mechanistic viewpoint an estimation problem can be formulated where the knowns are topography and gravity and the principal unknown the elastic flexural rigidity of the lithosphere. In the guise of an equivalent "effective elastic thickness", this important, geographically varying, structural parameter has been the subject of many interpretative studies, but precisely how well it is known or how best it can be found from the data, abundant nonetheless, has remained contentious and unresolved throughout the last few decades of dedicated study. The popular methods whereby admittance or coherence, both spectral measures of the relation between gravity and topography, are inverted for the flexural rigidity, have revealed themselves to have insufficient power to independently constrain both it and the additional unknown initial-loading fraction and load-correlation fac- tors, respectively. Solving this extremely ill-posed inversion problem leads to non-uniqueness and is further complicated by practical considerations such as the choice of regularizing data tapers to render the analysis sufficiently selective both in the spatial and spectral domains. Here, we rewrite the problem in a form amenable to maximum-likelihood estimation theory, which we show yields unbiased, minimum-variance estimates of flexural rigidity, initial-loading frac- tion and load correlation, each of those separably resolved with little a posteriori correlation between their estimates. We are also able to separately characterize the isotropic spectral shape of the initial loading processes.
description: 41 pages, 13 figures, accepted for publication by Geophysical Journal International
Exome reanalysis and proteomic profiling identified TRIP4 as a novel cause of cerebellar hypoplasia and spinal muscular atrophy (PCH1)
Creators: name: Töpf, Ana
name: Pyle, Angela
name: Griffin, Helen
name: Matalonga, Leslie
name: Schon, Katherine
name: Sickmann, Albert
name: Schara–Schmidt, Ulrike
name: Hentschel, Andreas
name: Chinnery, Patrick F.
name: Kölbel, Heike
name: Roos, Andreas
name: Horvath, Rita
name: Cohen, Enzo
name: Cuesta, Isabel
name: Danis, Daniel
name: Denommé-Pichon, Anne-Sophie
name: Duffourd, Yannis
name: Gilissen, Christian
name: Johari, Mridul
name: Laurie, Steven
name: Li, Shuang
name: Nelson, Isabelle
name: Paramonov, Ida
name: Peters, Sophia
name: Prasanth, Sivakumar
name: Robinson, Peter
name: Sablauskas, Karolis
name: Savarese, Marco
name: Steyaert, Wouter
name: Van Der Velde, Joeri K.
name: Vitobello, Antonio
name: Baets, Jonathan
name: Beijer, Danique
name: Bonne, Gisèle
name: Cossins, Judith
name: Evangelista, Teresinha
name: Ferlini, Alessandra
name: Hackman, Peter
name: Hanna, Michael G.
name: Houlden, Henry
name: Lau, Jarred
name: Lochmüller, Hanns
name: Macken, William L.
name: Musacchia, Francesco
name: Nascimento, Andres
name: Natera-De Benito, Daniel
name: Nigro, Vincenzo
name: Piluso, Giulio
name: Pini, Veronica
name: Pitceathly, Robert D. S.
name: Polavarapu, Kiran
name: Cruz, Pedro M. Rodriguez
name: Sarkozy, Anna
name: Selvatici, Rita
name: Thompson, Rachel
name: Torella, Annalaura
name: Udd, Bjarne
name: Van De Vondel, Liedewei
name: Vandrovcova, Jana
name: Zaharieva, Irina
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Brief Communication
/692/308/2056
/631/208/514/2254
/38/23
/45/22
/82/58
/82/80
/45/41
brief-communication

description: Abstract: TRIP4 is one of the subunits of the transcriptional coregulator ASC-1, a ribonucleoprotein complex that participates in transcriptional coactivation and RNA processing events. Recessive variants in the TRIP4 gene have been associated with spinal muscular atrophy with bone fractures as well as a severe form of congenital muscular dystrophy. Here we present the diagnostic journey of a patient with cerebellar hypoplasia and spinal muscular atrophy (PCH1) and congenital bone fractures. Initial exome sequencing analysis revealed no candidate variants. Reanalysis of the exome data by inclusion in the Solve-RD project resulted in the identification of a homozygous stop-gain variant in the TRIP4 gene, previously reported as disease-causing. This highlights the importance of analysis reiteration and improved and updated bioinformatic pipelines. Proteomic profile of the patient’s fibroblasts showed altered RNA-processing and impaired exosome activity supporting the pathogenicity of the detected variant. In addition, we identified a novel genetic form of PCH1, further strengthening the link of this characteristic phenotype with altered RNA metabolism.
Comparison of quantum binary experiments
Creators: name: Jencova, Anna
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A quantum binary experiment consists of a pair of density operators on a finite dimensional Hilbert space. An experiment E is called ε-deficient with respect to another experiment F if, up to ε, its risk functions are not worse than the risk functions of F, with respect to all statistical decision problems. It is known in the theory of classical statistical experiments that 1. for pairs of probability distributions, one can restrict to testing problems in the definition of deficiency and 2. that 0-deficiency is a necessary and sufficient condition for existence of a stochastic mapping that maps one pair onto the other. We show that in the quantum case, the property 1. holds precisely if E consist of commuting densities. As for property 2., we show that if E is 0-deficient with respect to F, then there exists a completely positive mapping that maps E onto F, but it is not necessarily trace preserving.
description: 13 pages; version accepted in Rep. Math. Phys, minor changes
Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science
Creators: name: Luppi, Andrea I.
name: Cain, Joshua
name: Spindler, Lennart R. B.
name: Górska, Urszula J.
name: Toker, Daniel
name: Hudson, Andrew E.
name: Brown, Emery N.
name: Diringer, Michael N.
name: Stevens, Robert D.
name: Massimini, Marcello
name: Monti, Martin M.
name: Stamatakis, Emmanuel A.
name: Boly, Melanie
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: The Curing Coma Campaign
Curing Coma Campaign
Brain injury
Coma
Consciousness
Electroencephalography
Magnetic resonance imaging
Neuroimaging
Mechanism

description: Funder: Tiny Blue Dot Foundation
description: Funder: Templeton World Charity Foundation; doi: http://dx.doi.org/10.13039/501100011730
description: Funder: Cambridge Commonwealth, European and International Trust; doi: http://dx.doi.org/10.13039/501100003343
description: Funder: Gates Cambridge Trust; doi: http://dx.doi.org/10.13039/501100005370
description: Abstract: Aim: In order to successfully detect, classify, prognosticate, and develop targeted therapies for patients with disorders of consciousness (DOC), it is crucial to improve our mechanistic understanding of how severe brain injuries result in these disorders. Methods: To address this need, the Curing Coma Campaign convened a Mechanisms Sub-Group of the Coma Science Work Group (CSWG), aiming to identify the most pressing knowledge gaps and the most promising approaches to bridge them. Results: We identified a key conceptual gap in the need to differentiate the neural mechanisms of consciousness per se, from those underpinning connectedness to the environment and behavioral responsiveness. Further, we characterised three fundamental gaps in DOC research: (1) a lack of mechanistic integration between structural brain damage and abnormal brain function in DOC; (2) a lack of translational bridges between micro- and macro-scale neural phenomena; and (3) an incomplete exploration of possible synergies between data-driven and theory-driven approaches. Conclusion: In this white paper, we discuss research priorities that would enable us to begin to close these knowledge gaps. We propose that a fundamental step towards this goal will be to combine translational, multi-scale, and multimodal data, with new biomarkers, theory-driven approaches, and computational models, to produce an integrated account of neural mechanisms in DOC. Importantly, we envision that reciprocal interaction between domains will establish a “virtuous cycle,” leading towards a critical vantage point of integrated knowledge that will enable the advancement of the scientific understanding of DOC and consequently, an improvement of clinical practice.
Prévention de la pénibilité : une approche contradictoire ?
Creators: name: Maggi, Bruno
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: IUS/07 Diritto del lavoro
M-PSI/06 Psicologia del lavoro e delle organizzazioni
MED/44 Medicina del lavoro
SECS-P/08 Economia e gestione delle imprese
SPS/09 Sociologia dei processi economici e del lavoro

description: In France, recent  laws concerning retirement foresee the obligation to reach agreements in order to prevent some risks, whose disabling consequences imply forms of compensations. These norms raise a number of issues: the language used to define risks, damages and their consequences, generates ambiguities, and some contradictions with the norms concerning health and safety at work appear. It is plausible that this depends on distorted interpretations of the general prevention principles that have been widespread for a long time, which inhibit to reduce effectively the high rates of work accidents and professional diseases.
La svolta retorica e stilistica del secondo decennio del ventunesimo secolo: un personaggio letterario alla ricerca di nuovi spazi editoriali per saggi poetici e narrativi.
Creators: name: Tonfoni, Graziella
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: L-FIL-LET/11 Letteratura italiana contemporanea

description: In questo articolo, si confermano sia la periodizzazione storica precedente, relativa ai classici scientifici e didattici dell'autrice, che la svolta attuale, definitiva, della sua linea retorica e letteraria italiana.Si risolve il problema rimasto aperto, per alcuni anni, dai critici più scettici, che non si risolvevano a ritenerlo risolto, ovvero del come sia possibile per una scienziata di punta, rinunciare al suo intero patrimonio scientifico di un trentennio di ricerca, senza sentirsi oppressa dall' emozione di avere perso interi decenni della sua esistenza dedicata alla scienza avanzata. Attraverso la analisi di una sua attività parallela, letteraria, costante, seppur assai discreta, si dimostra,come la ricercatrice, pioniera interdisciplinare ed internazionalmente attiva come ingegnere dell'informazione, concepisse un autentico sogno, della sua esistenza fondata sulla quotidiana scrittura, e considerasse quindi il più autentico obiettivo, quello effettivamente letterario, fino dai suoi primi anni, di attività negli ambienti più prestigiosi della ricerca avanzata.Solo così si può finalmente comprendere, come le innumerevoli rinunce da lei sottoscritte, nei confronti di una rapida visibilità mediatica dei suoi prodotti di ricerca, a seguito di sue innovazioni di evidente, straordinaria rilevanza, siano state per lei di fatto prove di forza morale, abbastanza semplici da superare.
Sia per il senso di responsabilità, che chi opera nella scienza deve avere, nei confronti di teorie e metodi, di cui sia autrice, e che interessino poi il destino di numerosi utenti, sensibilità di cui la medesima è da anni anche effettiva testimonial e promotrice, ma anche perché la palese asperità, di alcune rinunce era effettivamente per lei mitigata dalla sua stessa innata aspirazione, a potere diventare quanto sempre aveva sognato di essere ovvero una semplice letterata, scrittrice di narrativa prosa.
Scalar Domain Wall as the Universe
Creators: name: Toyozato, Yuta
name: Bamba, Kazuharu
name: Nojiri, Shin'ichi
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We develop a formulation where for an arbitrarily given warp factor, we construct a scalar field action which reproduces the warp factor as a solution of the Einstein equation and field equation corresponding to the action. This formulation could be called as the reconstruction. By using the formulation of the reconstruction, we construct models which have an exact solution describing the domain wall. The shape of the domain wall can be flat, de Sitter space-time, or anti-de Sitter space-time. In the constructed domain wall solutions, there often appears ghost with negative kinetic energy. We give, however, an example of the de Sitter domain wall solution without ghost, which could be a toy model of inflation. We also investigate the localization of gravity as in the Randall-Sundrum model. It is demonstrated that the four dimensional Newton law could be reproduced even in the de Sitter space-time domain wall solution. We show that we can construct a space-time, where the domain wall is the general Friedmann-Robertson-Walker (FRW) universe and the warp factor can be arbitrary. For such a construction, we use two scalar fields. It is also illustrated that the scalar field equations are equivalent to the Bianchi identities: $\nabla^μ(R_{μν} - \frac{1}{2}R g_{μν})=0$.
description: LaTeX, 11 pages, veersion to appear in Phys. Rev. D, a new section is added
Uncertainties in the item parameter estimates and robust automated test assembly
Creators: name: Veldkamp, Bernard P.
name: Matteucci, Mariagiulia
name: De Jong, Martijn
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: M-PSI/03 Psicometria
MAT/09 Ricerca operativa
SECS-S/01 Statistica
SECS-S/05 Statistica sociale

description: IRT parameters have to be estimated, and because of the estimation process, they do have uncertainty in them. In most large scale testing programs, the parameters are stored in item banks, and automated test assembly algorithms are applied to assemble operational test forms. These algorithms treat item parameters as fixed values, and uncertainty is not taken into account. As a consequence, resulting tests might be off target or less informative than expected. In this paper, the process of parameter estimation is described to provide insight into the causes of uncertainty in the item parameters. The consequences of uncertainty are studied. Besides, an alternative automated test assembly algorithm is presented that is robust against uncertainties in the data. Several numerical examples demonstrate the performance of the robust test assembly algorithm, and illustrate the dangers of not taking this uncertainty into account. Finally, some recommendations about the use of robust test assembly and some directions for further research are given.
The use of predicted values for item parameters in item response theory models: an application in intelligence tests
Creators: name: Matteucci, Mariagiulia
name: Mignani, Stefania
name: Veldkamp, Bernard P.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: M-PSI/03 Psicometria
SECS-S/01 Statistica
SECS-S/05 Statistica sociale

description: In testing, item response theory models are widely used in order to estimate item parameters and individual abilities. However, even unidimensional models require a considerable sample size so that all parameters can be estimated precisely. The introduction of empirical prior information about candidates and items might reduce the number of candidates needed for parameter estimation. Using data for IQ measurement, this work shows how empirical information about items can be used effectively for item calibration and in adaptive testing. First, we propose multivariate regression trees to predict the item parameters based on a set of covariates related to the item solving process. Afterwards, we compare the item parameter estimation when tree fitted values are included in the estimation or when they are ignored. Model estimation is fully Bayesian, and is conducted via Markov chain Monte Carlo methods. The results are two-fold: a) in item calibration, it is shown that the introduction of prior information is effective with short test lengths and small sample sizes, b) in adaptive testing, it is demonstrated that the use of the tree fitted values instead of the estimated parameters leads to a moderate increase in the test length, but provides a considerable saving of resources.
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
Creators: name: Knatko, Elena V.
name: Castro, Cecilia
name: Higgins, Maureen
name: Zhang, Ying
name: Honda, Tadashi
name: Henderson, Colin J.
name: Wolf, C. Roland
name: Griffin, Julian L.
name: Dinkova-Kostova, Albena T.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/67
/631/154
/64
/64/60
article

description: Funder: Stony Brook Foundation Reata Pharmaceuticals
description: Abstract: Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism. Nrf2 activation is protective in models of human disease and has benefits in clinical trials. Consequently, the Keap1/Nrf2 protein complex is a drug target. However, in cancer Nrf2 plays a dual role, raising concerns that Nrf2 activators may promote growth of early neoplasms. To address this concern, we examined the role of Nrf2 in development of colorectal adenomas by employing genetic, pharmacological, and metabolomic approaches. We found that colorectal adenomas that form in Gstp−/−: ApcMin/+ mice are characterized by altered one-carbon metabolism and that genetic activation, but not disruption of Nrf2, enhances these metabolic alterations. However, this enhancement is modest compared to the magnitude of metabolic differences between tumor and peri-tumoral tissues, suggesting that the metabolic changes conferred by Nrf2 activation may have little contribution to the early stages of carcinogenesis. Indeed, neither genetic (by Keap1 knockdown) nor pharmacological Nrf2 activation, nor its disruption, affected colorectal adenoma formation in this model. We conclude that pharmacological Nrf2 activation is unlikely to impact the early stages of development of colorectal cancer.
La contemporaneità letteraria italiana nell'epoca della instabilità didattica e della turbolenza formativa
Creators: name: Tonfoni, Graziella
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: L-FIL-LET/11 Letteratura italiana contemporanea

description: La progettazione di un percorso redazionale, che sia una esperienza italiana pilota, assai particolare, da parte di una autrice, che produce letteratura italiana contemporanea, in liquidità diacronica di paragrafi sincronici, assegnando progressivamente manufatti da rivedere nel rispettivo layout, delle pagine, di cui controllare accuratamente, la stabilità stilistica, evitando il rischio di infiltrazioni semantiche da refusi solidi, invita ad astenersi da tentazioni di ipercorrettismo esistenziale.
Si inserisce nel quadro di rilancio pragmatico, delle più stabili e nobili tradizioni editoriali, che prevedevano un rapporto di profonda fiducia, di qualità effettiva, fra editor di case editrici antiche, e loro dedicati autori, fidelizzati, proprio grazie a questa essenziale prassi di sostegno emotivo, per intere generazioni, nei secoli precedenti. Tale sinergia affettiva, fu sempre positivamente efficace, divenuta valore aggiunto, nel panorama nazionale, mai considerata piattaforma superflua, né fase sostituibile da parte di software ammiccanti, da terminali anonimi. Questa ideale situazione fu indiscussa, fino alla pervasiva intrusione, di pratiche eccessive, di accesso a tool dedicati alla magia della formattazione. Il recupero di presenze competenti, stanziabili sul territorio a zolle, della refusologia, deve prescindere da considerazioni di ordine e grado: sia la effettiva abilità a rendere operatori, coloro che sanno dissodare, iscrivibili ad un albo apposito di tale assai pregiata corporazione. Siano lettori accurati e lettrici acute,quindi richiamabili al servizio prestigioso, encomiabile militanza,in un rapporto privilegiato, con un singolo autore.L'autrice dimostra come la identificazione di una presenza volonterosa e competente, già attiva e disponibile nella struttura attuale, incardinata in Alma Mater Studiorum, sia da preferirsi rispetto ad estemporanei interventi esterni, che si alternino. Stabilire un ruolo fisso di 'rilettora', responsabile e delicata, dedicata alla sua fluida prosa, per la nuova linea letteraria dal 2012, in poi, è passo imprescindibile. Le odierne stampabilità di una autrice, che esilia le sue prose, si articolano in paragrafi, che non contemplano più, suoi precedenti stili. Richiedono quindi, le stesse frasi, una diversa presenza, continuativa e motivata, per la revisione precisa, che sconfina nella frugale impaginazione. Mai scevra di buon gusto.Tale rimessa in discussione, della assoluta ed unica rilevanza, dei correttori automatici, apre nuovi orizzonti per una occupazione elegante, che si fonde, con la tradizione di un vero e proprio artigianato della pagina. In linea con il profilo estetico, corredato da affidabile logo, a timbro di provenienza, assicurato, dal Bel Paese Italia.
Fabrication of carbon nanotube structures using dielectrophoresis
Creators: name: Kashefian Naieni, Ali
Publisher: name: University of British Columbia
Year: 2014

description: Carbon nanotubes (CNTs) are promising materials for many applications due to their attractive electronic, optical, mechanical and thermal properties. Currently, the main challenge facing their widespread usage is the inability to fabricate nanotube devices reproducibly. Dielectrophoresis (DEP) is a versatile method for the fabrication of nanostructures from a solution. However, while this method offers advantages such as overall control over the positioning of the nanotubes and the possibility of pre-selecting the types of CNTs, there are many unknowns about how the process works, leading to unreliability and irreproducibility. Although there have been reports on different parameters affecting DEP results, some important factors such as the movement of the solution and the interactions among nanotubes during the process have often been neglected. This thesis presents a combination of experimental and modeling efforts to investigate the mechanisms at work during DEP. Experiments were performed to evaluate the influence of the conductivity of the solution. A framework based on finite-element method simulations was developed to unveil the mechanisms involved. The results showed that variations in the conductivity of the solution, leading to changes in electrothermal movements, could lead to substantial differences in the outcome. Higher levels of repeatability were achieved by using low-conductivity solutions. The mutual interactions of nanotubes during DEP were also investigated using both experiments and simulations; it was shown that these could lead to the formation of periodic patterns in the deposited nanotubes. Finally, a particle tracing simulation formalism was developed, allowing one to follow the CNTs in their journey from the solution to the substrate, taking into account several influential factors: the DEP force, the movement of the solution itself, and the Brownian movement of the CNTs. Metallic and semiconducting nanotubes were traced in various scenarios and the effective forces were explored every step of the way. The work reported in this thesis thus leads to a better understanding of the DEP process and the mechanisms involved in the deposition of nanotubes, and potentially that of other nano-objects, taking us a step closer to engineering reproducible processes for nano-device fabrication.
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
Creators: name: Meddens, S. Fleur W.
name: De Vlaming, Ronald
name: Bowers, Peter
name: Burik, Casper A. P.
name: Linnér, Richard Karlsson
name: Lee, Chanwook
name: Okbay, Aysu
name: Turley, Patrick
name: Rietveld, Cornelius A.
name: Fontana, Mark Alan
name: Ghanbari, Mohsen
name: Imamura, Fumiaki
name: McMahon, George
name: Van Der Most, Peter J.
name: Voortman, Trudy
name: Wade, Kaitlin H.
name: Anderson, Emma L.
name: Braun, Kim V. E.
name: Emmett, Pauline M.
name: Esko, Tonũ
name: Gonzalez, Juan R.
name: Kiefte-De Jong, Jessica C.
name: Langenberg, Claudia
name: Luan, Jian’an
name: Muka, Taulant
name: Ring, Susan
name: Rivadeneira, Fernando
name: Snieder, Harold
name: Van Rooij, Frank J. A.
name: Wolffenbuttel, Bruce H. R.
name: Smith, George Davey
name: Franco, Oscar H.
name: Forouhi, Nita G.
name: Ikram, M. Arfan
name: Uitterlinden, Andre G.
name: Van Vliet-Ostaptchouk, Jana V.
name: Wareham, Nick J.
name: Cesarini, David
name: Harden, K. Paige
name: Lee, James J.
name: Benjamin, Daniel J.
name: Chow, Carson C.
name: Koellinger, Philipp D.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/208
/692/699
article

description: Abstract: We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 × 10−8), while five of the 21 lead SNPs reach suggestive significance (P < 1 × 10−5) for at least one other macronutrient. While the phenotypes are genetically correlated, each phenotype carries a partially unique genetic architecture. Relative protein intake exhibits the strongest relationships with poor health, including positive genetic associations with obesity, type 2 diabetes, and heart disease (rg ≈ 0.15–0.5). In contrast, relative carbohydrate and sugar intake have negative genetic correlations with waist circumference, waist-hip ratio, and neighborhood deprivation (|rg| ≈ 0.1–0.3) and positive genetic correlations with physical activity (rg ≈ 0.1 and 0.2). Relative fat intake has no consistent pattern of genetic correlations with poor health but has a negative genetic correlation with educational attainment (rg ≈−0.1). Although our analyses do not allow us to draw causal conclusions, we find no evidence of negative health consequences associated with relative carbohydrate, sugar, or fat intake. However, our results are consistent with the hypothesis that relative protein intake plays a role in the etiology of metabolic dysfunction.
La letteratura quotidiana italiana del XXI secolo: dispositivi ad alta precisione poetica per il rilevamento ed il contenimento di fenomeni di cyber-bullying in formato nazionale.
Creators: name: Tonfoni, Graziella
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: L-FIL-LET/11 Letteratura italiana contemporanea

description: In questo saggio, l' autrice, che da alcuni mesi è stata invitata a prendere atto ufficialmente, di una fenomenologia internet, assai conturbante, ed a sottoscrivere per un intero anno accademico, di lavorare come osservatrice scientifica del tutto super partes, identifica, ed analizza, le dinamiche della produzione di notizie spurie, influenzate dal vistoso e grave fenomeno del cyber-bullying, esprimendo particolare preoccupazione nei confronti di liquami di informazione autoctona, assai inquinante, diffusi, senza filtro e circolati istantaneamente, senza una accorta verifica delle fonti. Considera il ruolo ambiguo, di alcuni sistemi di reperimento di notizie prive di fondamento, impacchettate per nuocere, disruptive packaging for hideus data mining, che circolano in social network, sulla base di motori di ricerca, semantic search engine, progettati, senza alcun tipo di controllo pragmatico, senza sufficiente supervisione da parte di esperti del settore, mai invitati a collaudare. Indica con preoccupazione, la esistenza di prodotti stoccati appositamente, progettati per funzionare con procedure fisse, di stalking ad personam, appositamente disegnati per richiamare con nessi a trigger, intere filiere, estratte da cronache nere, sulla base della markedness, ovvero marcatezza denotativa di rimbalzo, ricavata attraverso una serie di keyword connotative, per trascinamento indotto al negativo. Si deduce, come soltanto chi abbia acquisito negli anni, stabili competenze, nella elaborazione automatica dei testi, possa effettivamente accorgersi, di un fenomeno che, uscito dal web, si traduce meccanicamente poi in azioni turbative, sul territorio, destinate a divulgare con ubiquito story telling , conclusioni improprie, che possano continuare a diffondere tale epopea al negativo. Con la vasta copertura di cellulari, le operazioni tese ad abbassare costantemente la fiducia in una autrice unica, si materializzano attraverso chiamate di numeri, a linee assai chiare, in una composizione collaborativa di sms, in scritture meccaniche, che proprio per la loro totale artificiosità, l' autrice riconosce immediatamente e capta. Scientificamente descrive, mutuando la definizione dal settore chimico dei prodotti plastici, del teflon, tali interazioni giovanili coatte, nei termini di automatiche frasi di istigazione, rese in materiale telfon.
La ricostruzione della balista di Vitruvio
Creators: name: Molari, Pier Gabriele
name: Maraldi, Mirko
name: Angelini, Guido
name: Bignami, Stefano
name: Lionello, Giacomo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: ING-IND/14 Progettazione meccanica e costruzione di macchine
M-STO/05 Storia della scienza e delle tecniche

description: Viene riportato il lavoro svolto durante le esercitazioni del primo anno dell’insegnamento Laboratorio di storia dell’ingegneria meccanica, tenuto presso la Facoltà di Ingegneria dell’Università di Bologna.
La descrizione della balista di Vitruvio offre un esempio di progettazione modulare basato sul valore del diametro degli elementi elastici. La lettura critica del testo a noi pervenuto porta ad esaminare i disegni del Valturio, quelli di Fra Giocondo e le conclusioni del Barbaro, anche in relazione alle macchine scolpite sulla colonna Traiana.
La funzione che interpola i dati di Vitruvio garantisce che macchine di diversa taglia, sollecitate nello stesso modo, a parità di alzo, abbiano la stessa gittata e quindi che il proietto abbia uguale velocità iniziale. Si trova anche che la palla da lanciare può essere usata come calibro per i fori per i quali passa la matassa elastica.
Si tenta una argomentata ricostruzione della macchina, basandosi su calcoli, prove sui materiali e disegni.
La struttura della macchina viene confrontata con quella di recenti ricostruzioni rintracciate in rete ed in letteratura. 
Si passa quindi allo “studio”, al disegno del complessivo e ai disegni costruttivi.
In attesa della costruzione reale … si simulano le prove di lancio.