cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes
Creators: name: Xue, Zhuyi
name: Warren, René L
name: Gibb, Ewan A
name: MacMillan, Daniel
name: Wong, Johnathan
name: Chiu, Readman
name: Hammond, S. Austin
name: Yang, Chen
name: Nip, Ka M
name: Ennis, Catherine A
name: Hahn, Abigail
name: Reynolds, Sheila
name: Birol, Inanc
Publisher: name: BioMed Central
Year: 2018

description: Background: Alternative polyadenylation (APA) results in messenger RNA molecules with different 3′ untranslated regions (3’ UTRs), affecting the molecules’ stability, localization, and translation. APA is pervasive and implicated in cancer. Earlier reports on APA focused on 3’ UTR length modifications and commonly characterized APA events as 3’ UTR shortening or lengthening. However, such characterization oversimplifies the processing of 3′ ends of transcripts and fails to adequately describe the various scenarios we observe. Results: We built a cloud-based targeted de novo transcript assembly and analysis pipeline that incorporates our previously developed cleavage site prediction tool, KLEAT. We applied this pipeline to elucidate the APA profiles of 114 genes in 9939 tumor and 729 tissue normal samples from The Cancer Genome Atlas (TCGA). The full set of 10,668 RNA-Seq samples from 33 cancer types has not been utilized by previous APA studies. By comparing the frequencies of predicted cleavage sites between normal and tumor sample groups, we identified 77 events (i.e. gene-cancer type pairs) of tumor-specific APA regulation in 13 cancer types; for 15 genes, such regulation is recurrent across multiple cancers. Our results also support a previous report showing the 3’ UTR shortening of FGF2 in multiple cancers. However, over half of the events we identified display complex changes to 3’ UTR length that resist simple classification like shortening or lengthening. Conclusions: Recurrent tumor-specific regulation of APA is widespread in cancer. However, the regulation pattern that we observed in TCGA RNA-seq data cannot be described as straightforward 3’ UTR shortening or lengthening. Continued investigation into this complex, nuanced regulatory landscape will provide further insight into its role in tumor formation and development.
Dépouillement et identité chez Jacques et Ricoeur : étude comparative.
Creators: name: Beaudoin, Simon.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Philosophy.

description: Cette thèse s'inscrit dans la problématique générale de l'identité personnelle. Plus précisément, elle questionne la fonction du dépouillement dans la perspective d'une réalisation authentique de soi chez Francis Jacques et Paul Ricoeur. Dans le corps de la thèse, l'auteur présente les modèles d'identité de ces deux auteurs selon les thèmes de la question de départ: l'authenticité et la fonction du dépouillement. À cette fin, il analyse certaines dimensions de la pensée de Jacques--ontologie de la relation, personne, individu, solitude, force illocutoire du silence, compétence pragmatique, etc.--et de Ricoeur--visée éthique, distinction de l'idem et de l'ipse, attestation, disponibilité, etc. En conclusion, l'auteur compare thématiquement les deux modèles d'identité afin de faire ressortir leurs points de convergence, de divergence et, surtout, de complémentarité. C'est ainsi qu'apparaissent un tant soit peu certaines forces et limites des deux approches philosophiques.
Methodological utility of chemerin as a novel biomarker of immunity and metabolism
Creators: name: Eichelmann, Fabian
name: Weikert, Cornelia
name: Di Giuseppe, Romina
name: Biemann, Ronald
name: Isermann, Berend
name: Schulze, Matthias B.
name: Boeing, Heiner
name: Aleksandrova, Krasimira
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: adipokine
subject: immune system
subject: reliability
subject: chemerin
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses. Intra-individual reproducibility of chemerin measurements was assessed by calculating intraclass correlation coefficients (ICCs) and exploration of Bland–Altman plots. Reliability analyses revealed good reproducibility of chemerin measurements (ICC: 0.72 (95%-CI 0.65, 0.78)). Visual inspection of Bland–Altman plots confirmed that the two time point measurements had a high level of agreement. In correlation analyses, chemerin was positively correlated with adiposity measures (body mass index and waist circumference). In addition, independent of adiposity measures, chemerin was correlated with the biomarkers C-reactive protein, fatty acid-binding protein 4 and progranulin (Rho-s ranging from 0.23 to 0.37). In multivariable linear regression analysis, a combination of correlated factors including body mass index, waist circumference, C-reactive protein, progranulin and fatty acid- binding protein-4 explained 28.0% of chemerin concentrations. These findings demonstrate methodological utility of chemerin concentrations in population- based research setting. Human studies are highly warranted in order to provide further insights into the role of chemerin as a biomarker linking immunity and metabolism in relation to chronic disease risk.
Determining the contribution of retinotopic discrimination to localization performance with a suprachoroidal retinal prosthesis
Creators: name: Petoe, Matthew A.
name: McCarthy, Christopher
name: Shivdasani, Mohit N.
name: Sinclair, Nicholas C.
name: Scott, Adele F.
name: Ayton, Lauren N.
name: Barnes, Nick M.
name: Guymer, Robyn H.
name: Allen, Penelope J.
name: Blamey, Peter J.
Publisher: name: Swinburne
Year: 2024

description: Purpose: With a retinal prosthesis connected to a head-mounted camera, subjects can perform low vision tasks using a combination of electrode discrimination and head-directed localization. The objective of the present study was to investigate the contribution of retinotopic electrode discrimination (perception corresponding to the arrangement of the implanted electrodes with respect to their position beneath the retina) to visual performance for three recipients of a 24-channel suprachoroidal retinal implant. Proficiency in retinotopic discrimination may allow good performance with smaller head movements, and identification of this ability would be useful for targeted rehabilitation.
Methods: Three participants with retinitis pigmentosa performed localization and grating acuity assessments using a suprachoroidal retinal prosthesis. We compared retinotopic and nonretinotopic electrode mapping and hypothesized that participants with measurable acuity in a normal retinotopic condition would be negatively impacted by the nonretinotopic condition. We also expected that participants without measurable acuity would preferentially use head movement over retinotopic information.
Results: Only one participant was able to complete the grating acuity task. In the localization task, this participant exhibited significantly greater head movements and significantly lower localization scores when using the nonretinotopic electrode mapping. There was no significant difference in localization performance or head movement for the remaining two subjects when comparing retinotopic to nonretinotopic electrode mapping.
Conclusions: Successful discrimination of retinotopic information is possible with a suprachoroidal retinal prosthesis. Head movement behavior during a localization task can be modified using a nonretinotopic mapping. Behavioral comparisons using retinotopic and nonretinotopic electrode mapping may be able to highlight deficiencies in retinotopic discrimination, with a view to address these deficiencies in a rehabilitation environment. (ClinicalTrials.gov number, NCT01603576).
title: Enfermedad de gorham: El síndrome del hueso evanescente
Creators: name: Massó Odriozola, Amaia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Paediatric
subject: Bones

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Revisar la Enfermedad de Gorham,
también denominada osteolisis masiva o linfangiomatosis ósea.
Una entidad poco conocida e infrecuente,
sobre la que presentamos dos pacientes diagnosticados en nuestro...
title: RM ENTEROGRAFÍA: técnica y resultados
Creators: name: Ramiro Ayan, Laura
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir la técnica de la RM-enterografía en la Enfermedad de Crohn y su aplicación en la práctica diaria por parte de la sección de radiología abdominal de nuestro hospital. Mostrar los distintos hallazgos que podemos encontrar en esta...
title: Die regionale Oberflaechenwaermeflussdichte-Verteilung in den zentralen Anden und daraus abgeleitete Temperaturmodelle der Lithosphaere
Creators: name: Springer, Michael
Publisher: name: Deutsches GeoForschungsZentrum GFZ
Year: 2012

description: Scientific Technical Report; 97/05; ISSN 1610-0956
Der Blaue Engel
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: subject: Produktkennzeichnung
subject: Blauer Engel
subject: umweltfreundliche Produkte
subject: Wirtschaft | Konsum
subject: Economy | Consumption

description: Das Umweltbundesamt erarbeitet spezifische Standards für Produkte und Dienstleistungen und passt sie stets an den aktuellen Stand der Technik an. Unterstützt wird es dabei von Umwelt- und Verbraucherorganisationen sowie Herstellern. So können Sie sicher sein, dass nur die ökologisch Besten das Umweltzeichen tragen.
Pulse duration of seeded free-electron lasers
Creators: name: Finetti, Paola
name: Höppner, Hauke
name: Allaria, Enrico
name: Callegari, Carlo
name: Capotondi, Flavio
name: Cinquegrana, Paolo
name: Coreno, Marcello
name: Cucini, Riccardo
name: Danailov, Miltcho B.
name: Demidovich, Alexander
name: Ninno, Giovanni De
name: Fraia, Michele Di
name: Feifel, Raimund
name: Ferrari, Eugenio
name: Fröhlich, Lars
name: Gauthier, David
name: Golz, Torsten
name: Grazioli, Cesare
name: Kai, Yun
name: Kurdi, Gabor
name: Mahne, Nicola
name: Manfredda, Michele
name: Medvedev, Nikita
name: Nikolov, Ivaylo P.
name: Pedersoli, Emanuele
name: Penco, Giuseppe
name: Plekan, Oksana
name: Prince, Kevin
name: Prince, Kevin C.
name: Raimondi, Lorenzo
name: Rebernik, Primoz
name: Riedel, Robert
name: Roussel, Eleonore
name: Sigalotti, Paolo
name: Squibb, Richard
name: Stojanovic, Nikola
name: Stranges, Stefano
name: Svetina, Cristian
name: Tanikawa, Takanori
name: Teubner, Ulrich
name: Tkachenko, Victor
name: Toleikis, Sven
name: Zangrando, Marco
name: Ziaja, Beata
name: Tavella, Franz
name: Giannessi, Luca
Publisher: name: Swinburne
Year: 2024

description: The pulse duration, and, more generally, the temporal intensity profile of free-electron laser (FEL) pulses, is of utmost importance for exploring the new perspectives offered by FELs; it is a nontrivial experimental parameter that needs to be characterized. We measured the pulse shape of an extreme ultraviolet externally seeded FEL operating in high-gain harmonic generation mode. Two different methods based on the cross-correlation of the FEL pulses with an external optical laser were used. The two methods, one capable of single-shot performance, may both be implemented as online diagnostics in FEL facilities. The measurements were carried out at the seeded FEL facility FERMI. The FEL temporal pulse characteristics were measured and studied in a range of FEL wavelengths and machine settings, and they were compared to the predictions of a theoretical model. The measurements allowed a direct observation of the pulse lengthening and splitting at saturation, in agreement with the proposed theory.
Untersuchung der Auswirkungen ausgewählter nanotechnischer Produkte auf den Rohstoff- und Energiebedarf
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: subject: Energieeffizienz
subject: LCA [Life Cycle Assessment]
subject: Nanotechnik
subject: Organische Photovoltaik
subject: Rohstoffeffizienz
subject: Nanomaterialien
subject: Nanotechnisches Produkt
subject: Rohstoffeinsparung
subject: Energieeinsparpotenzial
subject: Klima | Energie
subject: Abfall | Ressourcen
subject: Climate | Energy
subject: Waste | Resources

description: In der vorliegenden Studie werden für besonders aussichtsreiche nanotechnische Anwendungs-felder die zu erwartenden Rohstoff- und Energieaufwendungen qualitativ und so weit wie möglich quantitativ beschrieben. Hierzu wurden insbesondere elektrisch dimmbare Fenster (Fa. EControl-Glas GmbH & Co. KG) und organische Photovoltaik-Module (Fa. BELECTRIC OPV GmbH) einer quantitativen Analyse mit unternehmensspezifischen Daten unterzogen. Die Ergebnisse aus den beiden Fallbeispielen zeigen, dass diese Innovationen grundsätzlich signifi-kante Einsparungen im Bereich der Rohstoff- und Energieaufwendungen ermöglichen können.
Quelle: www.umweltbundesamt.de

description: In der vorliegenden Studie werden für besonders aussichtsreiche nanotechnische Anwendungs-felder die zu erwartenden Rohstoff- und Energieaufwendungen qualitativ und so weit wie möglich quantitativ beschrieben. Hierzu wurden insbesondere elektrisch dimmbare Fenster (Fa. EControl-Glas GmbH & Co. KG) und organische Photovoltaik-Module (Fa. BELECTRIC OPV GmbH) einer quantitativen Analyse mit unternehmensspezifischen Daten unterzogen. Die Ergebnisse aus den beiden Fallbeispielen zeigen, dass diese Innovationen grundsätzlich signifi-kante Einsparungen im Bereich der Rohstoff- und Energieaufwendungen ermöglichen können.
In Their Finest Hour: Deciphering the Role of the Canadian Women's Movement in the Formulation of the Charter of Rights and Freedoms
Creators: name: Gill, Amy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: History, Canadian.
subject: Women's Studies.

description: This thesis analyzes the role of the Canadian women's movement in the formulation of sections 15 and 28 in the Canadian Charter of Rights and Freedoms. Grounded in the context of the decade leading up to the 1980-1982 mega-constitutional debates, the ideas and actions of the women's movement demonstrate both their intellectual and political agency in securing a new interpretation of equality rights within the Charter. Intellectually, women drew on the legal experiences of Canadian, American, and international interpretations of equality as well as feminist ideology to conceive of a more substantive equality. Built out of two principles, equality of opportunity and equality of results, Canadian women devised a new language to reinforce the interpretation of substantive equality and sought out the means to transform their idea into reality. The success of the women's movement in this era is typically attributed to its effective mobilization, profiting from an environment in which Canadian women were able to develop a complex network of organizations at the national, provincial, local, and grass roots level. Moreover, the structure of the women's movement provided a powerful platform for key figures within the movement to articulate women's concerns and have those opinions respectfully considered. Only in tandem do the ideals championed by the women's movement and the structure of the movement allow for its eventual success. The women's movement was riddled by strong cleavages, including ideological, regional, class, and ethnic cleavages, but held together in this era by a common commitment to substantive equality. Providing an arena for action, the critical events that mark the 1980-1982 mega-constitutional debates showcase these elements and illustrate how Canadian women transformed their ideas into action. Examining the context leading up to the debates along with the events during the fourteen-month span of negotiations, it is argued that women played both an intellectual and political role in shaping equality rights in Canada. Their contributions not only secured an effective path to substantive equality but also irrevocably altered the nature of the debate surrounding human rights and changed the way Canadians understand, interpret, and practice equality.
The SLUGGS survey: dark matter fractions at large radii and assembly epochs of early-type galaxies from globular cluster kinematics
Creators: name: Alabi, Adebusola B.
name: Forbes, Duncan
name: Romanowsky, Aaron J.
name: Brodie, Jean
name: Strader, Jay
name: Janz, Joachim
name: Usher, Christopher
name: Spitler, Lee R.
name: Bellstedt, Sabine
name: Ferre-Mateu, Anna
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We use globular cluster kinematics data, primarily from the SAGES Legacy Unifying Globulars and GalaxieS (SLUGGS) survey, to measure the dark matter fraction (f(DM)) and the average dark matter density () within the inner 5 effective radii (Re) for 32 nearby early-type galaxies (ETGs) with stellar mass log (M-*/M-circle dot) ranging from 10.1 to 11.8. We compare our results with a simple galaxy model based on scaling relations as well as with cosmological hydrodynamical simulations where the dark matter profile has been modified through various physical processes. We find a high f(DM) (>= 0.6) within 5 Re in most of our sample, which we interpret as a signature of a late mass assembly history that is largely devoid of gas-rich major mergers. However, around log (M-*/M-circle dot) similar to 11, there is a wide range of f(DM) which may be challenging to explain with any single cosmological model. We find tentative evidence that lenticulars (S0s), unlike ellipticals, have mass distributions that are similar to spiral galaxies, with decreasing f(DM) within 5 Re as galaxy luminosity increases. However, we do not find any difference between the < DM > of S0s and ellipticals in our sample, despite the differences in their stellar populations. We have also used to infer the epoch of halo assembly (z similar to 2-4). By comparing the age of their central stars with the inferred epoch of halo formation, we are able to gain more insight into their mass assembly histories. Our results suggest a fundamental difference in the dominant late-phase mass assembly channel between lenticulars and elliptical galaxies.
Discovery of a z = 0.65 post-starburst BAL quasar in the DES supernova fields
Creators: name: Mudd, Dale
name: Martini, Paul
name: Tie, Suk Sien
name: Lidman, Chris
name: McMahon, Richard
name: Banerji, Manda
name: Davis, Tamara
name: Peterson, Bradley
name: Sharp, Rob
name: Seymour, Nicholas
name: Childress, Michael
name: Lewis, Geraint
name: Tucker, Brad
name: Yuan, Fang
name: Abbot, Tim
name: Abdalla, Filipe
name: Allam, Sahar
name: Benoit-Lévy, Aurélien
name: Bertin, Emmanuel
name: Brooks, David
name: Camero Rosell, A.
name: Kind, Matias Carrasco
name: Carretero, Jorge
name: da Costa, Luiz N.
name: Desai, Shantanu
name: Diehl, Thomas
name: Eifler, Tim
name: Finley, David
name: Flaugher, Brenna
name: Glazebrook, Karl
name: Gruen, Daniel
name: Gruendl, Robert
name: Gutierrez, Gaston
name: Hinton, Samuel
name: Honscheid, Klaus
name: James, David
name: Kuehn, Kyler
name: Kuropatkin, Nikolav
name: Macaulay, Edward
name: Maia, Marcio A.G.
name: Miquel, Ramon
name: Ogando, Ricardo
name: Plazas, Andres
name: Riel, Kevin
name: Sanchez, Eusebio
name: Santiago, Basillio
name: Schubnell, Michael
name: Sevilla-Noarbe, Ignacio
name: Smith, Robert C.
name: Soares-Santos, Marcelle
name: Sobreira, Flavia
name: Suchyta, Eric
name: Swanson, Molly
name: Tarle, Gregory
name: Thomas, Daniel
name: Uddin, Syed
name: Walker, Alistair
name: Zhang, Bonnie
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We present the discovery of a z = 0.65 low-ionization broad absorption line (LoBAL) quasar in a post-starburst galaxy in data from the Dark Energy Survey (DES) and spectroscopy from the Australian Dark Energy Survey (OzDES). LoBAL quasars are a minority of all BALs, and rarer still is that this object also exhibits broad Fe II (an FeLoBAL) and Balmer absorption. This is the first BAL quasar that has signatures of recently truncated star formation, which we estimate ended about 40 Myr ago. The characteristic signatures of an FeLoBAL require high column densities, which could be explained by the emergence of a young quasar from an early, dust-enshrouded phase, or by clouds compressed by a blast wave. The age of the starburst component is comparable to estimates of the lifetime of quasars, so if we assume the quasar activity is related to the truncation of the star formation, this object is better explained by the blast wave scenario.
Web-based intervention to improve quality of life in late stage bipolar disorder (ORBIT): randomised controlled trial protocol
Creators: name: Fletcher, Kathryn
name: Foley, Fiona
name: Thomas, Neil
name: Michalak, Erin E.
name: Berk, Lesley
name: Berk, Michael
name: Bowe, Steve
name: Cotton, Sue
name: Engel, Lidia
name: Johnson, Sheri L.
name: Jones, Steven
name: Kyrios, Michael
name: Lapsley, Sara
name: Mihalopoulos, Cathrine
name: Perich, Tania
name: Murray, Greg
Publisher: name: BioMed Central
Year: 2018

description: Background: The primary objective of this randomised controlled trial (RCT) is to establish the effectiveness of a novel online quality of life (QoL) intervention tailored for people with late stage (≥ 10 episodes) bipolar disorder (BD) compared with psychoeducation. Relative to early stage individuals, this late stage group may not benefit as much from existing psychosocial treatments. The intervention is a guided self-help, mindfulness based intervention (MBI) developed in consultation with consumers, designed specifically for web-based delivery, with email coaching support. Methods/design: This international RCT will involve a comparison of the effectiveness and cost-effectiveness of two 5-week adjunctive online self-management interventions: Mindfulness for Bipolar 2.0 and an active control (Psychoeducation for Bipolar). A total of 300 participants will be recruited primarily via social media channels. Main inclusion criteria are: a diagnosis of BD (confirmed via a phone-administered structured diagnostic interview), no current mood episode, history of 10 or more mood episodes, no current psychotic features or active suicidality, under the care of a medical practitioner. Block randomisation will be used for allocation to the interventions, and participants will retain access to the program for 6 months. Evaluations will be conducted at pre- and post- treatment, and at 3- and 6- months follow-up. The primary outcome measure will be the Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD), collected immediately post-intervention at 5 weeks (T1). Secondary measures include BD-related symptoms (mania, depression, anxiety, stress), time to first relapse, functioning, sleep quality, social rhythm stability and resource use. Measurements will be collected online and via telephone assessments at baseline (T0), 5 weeks (T1), three months (T2) and six months (T3). Candidate moderators (diagnosis, anxiety or substance comorbidities, demographics and current treatments) will be investigated as will putative therapeutic mechanisms including mindfulness, emotion regulation and self-compassion. A cost-effectiveness analysis will be conducted. Acceptability and any unwanted events (including adverse treatment reactions) will be documented and explored. Discussion: This definitive trial will test the effectiveness and cost-effectiveness of a novel QoL focused, mindfulness based, online guided self-help intervention for late stage BD, and investigate its putative mechanisms of therapeutic action. Trial registration: ClinicalTrials.gov : NCT03197974 . Registered 23 June 2017.
The Effect of Measurement Errors on the Double Sampling X̅ Chart
Creators: name: Si, Kama Sherab Khee Yong
Publisher: name: Swinburne
Year: 2024

description: Measurement errors are invariable and their appearance will adversely affect the performance of the control chart judging the quality of the product. The effect of measurement errors on the double sampling (DS) X̅ chart is investigated using the linear covariate error model, thereby accurately determining the status of the production process based on the inspected products with measurement errors. Furthermore, the proposed DS X̅ chart designed under the statistical and economic criteria contributes to producing high-quality products in a cost-effective manner.
A novel Coltivirus-related virus isolated from free-tailed bats from Côte d’Ivoire is able to infect human cells in vitro
Creators: name: Weiss, Sabrina
name: Dabrowski, Piotr Wojtek
name: Kurth, Andreas
name: Leendertz, Siv Aina J.
name: Leendertz, Fabian H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Reoviridae
subject: Chiroptera
subject: Bats
subject: Coltivirus
subject: Chaereophon aloysiisabaudiae
subject: Colorado tick fever
subject: Spinareovirinae
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Zoonotic transmission events play a major role in the emergence of novel diseases. While such events are virtually impossible to predict, wildlife screening for potential emerging pathogens can be a first step. Driven by recent disease epidemics like severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and Ebola, bats have gained special interest as reservoirs of emerging viruses. Methods: As part of a bigger study investigating pathogens in African bats we screened animals for the presence of known and unknown viruses. Results: We isolated and characterised a novel reovirus from blood of free-tailed bats (Chaereophon aloysiisabaudiae) captured in 2006 in Côte d’Ivoire. The virus showed closest relationship with two human pathogenic viruses, Colorado tick fever virus and Eyach virus, and was able to infect various human cell lines in vitro. Conclusion: The study shows the presence of a coltivirus-related virus in bats from Sub-Sahara Africa. Serological studies could help to assess its impact on humans or wildlife health.
MPEC 2024-L122 : 2024 LN3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 LN3

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Biomarkers of Presbycusis and Tinnitus in a Portuguese Older Population
Creators: name: Haider, Haula F.
name: Flook, Marisa
name: Aparicio, Mariana
name: Ribeiro, Diogo
name: Antunes, Marilia
name: Szczepek, Agnieszka J. [U.A.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Introduction: Presbycusis or age-related hearing loss (ARHL) is a ubiquitous health problem. It is estimated that it will affect up to 1.5 billion people by 2025. In addition, tinnitus occurs in a large majority of cases with presbycusis. Glutamate metabotropic receptor 7 (GRM7) and N-acetyltransferase 2 (NAT2) are some of the genetic markers for presbycusis. Objectives: To explore patterns of hearing loss and the role of GRM7 and NAT2 as possible markers of presbycusis and tinnitus in a Portuguese population sample. Materials and Methods: Tonal and speech audiometry, tinnitus assessment, clinical interview, and DNA samples were obtained from patients aged from 55 to 75 with or without tinnitus. GRM7 analysis was performed by qPCR. Genotyping of single nucleotide polymorphisms (SNPs) in NAT2 was performed by PCR amplification followed by Sanger sequencing or by qPCR. Results: We screened samples from 78 individuals (33 men and 45 women). T allele at GRM7 gene was the most observed (60.3% T/T and 33.3% A/T). Individuals with a T/T genotype have a higher risk for ARHL and 33% lower risk for tinnitus, compared to individuals with A/A and A/T genotype, respectively. Being a slow acetylator (53%) was the most common NAT2 phenotype, more common in men (55.8%). Intermediate acetylator was the second most common phenotype (35.9%) also more frequent in men (82.6%). Noise exposed individuals and individuals with ‘high frequency’ hearing loss seem to have a higher risk for tinnitus. Our data suggests that allele AT of GRM7 can have a statistically significant influence toward the severity of tinnitus. Conclusion: For each increasing year of age the chance of HL increases by 9%. The risk for ARHL was not significantly associated with GRM7 neither NAT2. However, we cannot conclude from our data whether the presence of T allele at GRM7 increases the odds for ARHL or whether the A allele has a protective effect. Genotype A/T at GRM7 could potentially be considered a biomarker of tinnitus severity. This is the first study evaluating the effect of GRM7 and NAT2 gene in tinnitus.
Analysis of Human Co-exposure to Lead and Cadmium Using Human Biomonitoring (HBM) Data in a Bayesian Copula-Based Regression Framework
Creators: name: Conrad, André
name: Sy, Moustapha
name: Jung, Christian
Publisher: name: My University
Year: 2023

description: The identifcation of human co-exposure to industrial chemicals or environmental substances is of high interest in human health risk assessment. Due to their ubiquity and persistence in the environment, heavy metals such as cadmium (Cd) and lead (Pb) are of particular concern. Approaches to adequately investigating combinations of these and other often highly correlated variables are lacking. This study proposes a modeling approach to investigate the co-exposure to Cd and Pb, and better understanding the variations of blood Cd and Pb (CdB and PbB, respectively) together with potentially determinant factors. A copula-based regression model was built, using Bayesian inference and Markov Chain Monte Carlo simulation, to relate CdB and PbB of 3- to 14-year-old children participating in the German Environmental Survey for Children (GerES IV) with socio-demographic and ancillary exposure-relevant information. A minor to negligible dependence between CdB and PbB was observed, suggesting that Cd and Pb are subject to difering exposure sources/pathways or kinetics within human body. Despite the resulting low association between CdB and PbB, the developed approach provides methodological bases for enhancing the assessment of the cumulative exposure to multiple substances and for deepening the understanding of the determinants of these exposures. © The Author(s) 2023
A Policing perspective of high-risk repeat family violence
Creators: name: Ingham, John Frederick
Publisher: name: Swinburne
Year: 2024

description: This research explored the complexities of policing high-risk repeat family violence in the Southern Metropolitan Region of Victoria, Australia. It identified that drugs, alcohol, mental health, the Family Violence Intervention Order process and the underpinning gendered philosophy of the Duluth Model adopted by Victoria Police had restricted police members in providing a balanced approach for all victims of high-risk repeat family violence.
This researcher proposes combining elements of the Duluth and Straus Models to develop an Integrated Family Violence Management Model to assist Police, the Government and Judiciary to provide a more balanced approach in the management of family violence.
The first interferometric detections of fast radio bursts
Creators: name: Caleb, Manisha
name: Flynn, Christopher
name: Bailes, Matthew
name: Barr, Ewan
name: Bateman, T.
name: Bhandari, S.
name: Campbell-Wilson, D.
name: Farah, W.
name: Green, A. J.
name: Hunstead, R. W.
name: Jameson, A.
name: Jankowski, F.
name: Keane, E. F.
name: Parthasarathy, A.
name: Ravi, V.
name: Rosado, P. A.
name: van Straten, W.
name: Venkatraman Krishnan, V.
Publisher: name: Swinburne
Year: 2024

description: We present the first interferometric detections of fast radio bursts (FRBs), an enigmatic new class of astrophysical transient. In a 180-d survey of the Southern sky, we discovered three FRBs at 843 MHz with the UTMOST array, as a part of commissioning science during a major ongoing upgrade. The wide field of view of UTMOST (approximate to 9 deg(2)) is well suited to FRB searches. The primary beam is covered by 352 partially overlapping fan -beams, each of which is searched for FRBs in real time with pulse widths in the range 0.655-42 ms, and dispersion measures <= 2000 pc cm(-3). Detections of FRBs with the UTMOST array place a lower limit on their distances of approximate to 10(4) km (limit of the telescope near -field) supporting the case for an astronomical origin. Repeating FRBs at UTMOST or an FRB detected simultaneously with the Parkes radio telescope and UTMOST would allow a few arcsec localization, thereby providing an excellent means of identifying FRB host galaxies, if present. Up to 100 h of followup for each FRB has been carried out with the UTMOST, with no repeating bursts seen. From the detected position, we present 3 sigma error ellipses of 15 arcsec x 8 degrees.4 on the sky for the point of origin for the FRBs. We estimate an all -sky FRB rate at 843 MHz above a fluence F-lim of 11 Jy ms of similar to 78 events sky(-1) d(-1) at the 95 per cent confidence level. The measured rate of FRBs at 843 MHz is two times higher than we had expected, scaling from the FRB rate at the Parkes radio telescope, assuming that FRBs have a flat spectral index and a uniform distribution in Euclidean space. We examine how this can be explained by FRBs having a steeper spectral index and/or a flatter logN-logF distribution than expected for a Euclidean Universe.
title: Sichere Arzneimitteltherapie. Medikamente sicher einnehmen.
Creators: name: Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ)
Publisher: name: Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Ärztliches Zentrum für Qualität in der Medizin (ÄZQ)
Year: 2011
Subjects: subject: 610 Medical sciences; Medicine

description: Kurzinformation für Patienten
Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease
Creators: name: Shin, Sun H
name: Park, Hye Y
name: Kang, Danbee
name: Cho, Juhee
name: Kwon, Sung O
name: Park, Joo H
name: Lee, Jae S
name: Oh, Yeon-Mok
name: Sin, Don D
name: Kim, Woo J
name: Lee, Sang-Do
Publisher: name: BioMed Central
Year: 2018

description: Background: Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association between the stability of blood eosinophils and long-term clinical outcomes in COPD patients has yet to be fully elucidated. This study aimed to evaluate the stability of blood eosinophils and its association with clinical outcomes in COPD patients. Methods: In total, 299 COPD patients from the Korean Obstructive Lung Disease cohort with at least two blood eosinophil measurements were included. Patients were stratified according to a cut-off of 300 cells/μL, and the association between eosinophil changes and all-cause mortality was analysed. The annual decline in forced expiratory volume in 1 s (FEV1), serial changes in St George’s Respiratory Questionnaire score (SGRQ), and exacerbations during follow-up were compared among eosinophil groups. Results: Patients were stratified into three groups according to the blood eosinophil cut-off: persistently < 300 cells/μL (PL; n = 175), variable (V; n = 68), and persistently ≥300 cells/μL (PH; n = 56). There were no significant differences in baseline characteristics (age, sex, smoking, body mass index, use of inhaled corticosteroids, exacerbations in the previous year, FEV1 (L or % predicted), or emphysema score) among the groups. During a median follow-up of 6.0 years, the PH group had a better survival rate than the PL group (adjusted mortality rate ratio, 0.29; 95% confidence interval, 0.09–0.97; P = 0.045). The PH group also showed improved symptoms and impact domains of SGRQ score compared to the PL group. No difference was found in annual FEV1 decline or exacerbations during follow-up among the groups. Conclusions: Patients with persistently high blood eosinophils had a better survival rate than those with persistently low blood eosinophils. Serial follow-up of blood eosinophils could help to predict outcomes in COPD patients.
title: Semiología en la colonografía-TC del carcinoma colorrectal
Creators: name: de Lara Bendahan, Victoria
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: Gastrointestinal tract
subject: CT

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir los hallazgos mediante colonografía-TC (CTC) del carcinoma colorrectal...
Comparison of pulsar positions from timing and very long baseline astrometry
Creators: name: Wang, J. B.
name: Coles, W. A.
name: Hobbs, G.
name: Shannon, Ryan
name: Manchester, R. N.
name: Kerr, M.
name: Yuan, J. P.
name: Wang, N.
name: Bailes, Matthew
name: Bhat, N. D. R.
name: Dai, S.
name: Dempsey, J.
name: Keith, M. J.
name: Lasky, P. D.
name: Levin, Y.
name: Oslowski, Stefan
name: Ravi, V.
name: Reardon, Daniel
name: Rosado, P. A.
name: Russell, C. J.
name: Spiewak, R.
name: van Straten, Willem
name: Toomey, L.
name: Wen, L.
name: You, X.-P.
name: Zhu, X.-J.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 5101
subject: Astronomical sciences
classificationCode: 5109
subject: Space sciences

description: Pulsar positions can be measured with high precision using both pulsar timing methods and very long baseline interferometry (VLBI). Pulsar timing positions are referenced to a solar-system ephemeris, whereas VLBI positions are referenced to distant quasars. Here, we compare pulsar positions from published VLBI measurements with those obtained from pulsar timing data from the Nanshan and Parkes radio telescopes in order to relate the two reference frames. We find that the timing positions differ significantly from the VLBI positions (and also differ between different ephemerides). A statistically significant change in the obliquity of the ecliptic of 2.16 +/- 0.33 mas is found for the JPL ephemeris DE405, but no significant rotation is found in subsequent JPL ephemerides. The accuracy with which we can relate the two frames is limited by the current uncertainties in the VLBI reference source positions and in matching the pulsars to their reference source. Not only do the timing positions depend on the ephemeris used in computing them, but also different segments of the timing data lead to varying position estimates. These variations are mostly common to all ephemerides, but slight changes are seen at the 10 mu as level between ephemerides.
Drivers, Challenges and Organisational Changes Associated with Integrated Reporting in Sri Lanka
Creators: name: Wijesinghe, K. D. G. Nayomi
Publisher: name: Swinburne
Year: 2024

description: This study investigates the influence of integrated reporting on organizations, with a focus on their preparedness and maturity in producing integrated reports. Empirical data was collected from interviews with listed companies and other influential actors promoting or involved in integrated reporting in Sri Lanka. The study reveals the pivotal role senior managers' personal attributes, such as self-efficacy (encompassing self-confidence, knowledge, experience), goals, and expectations relating to IR, play in facilitating or hindering the adoption and practice of integrated reporting. The challenges associated with the adoption and practice of integrated reporting are intrinsically tied to these specific managerial attributes and vary according to the maturity of the company in preparing integrated reports. Moreover, the extent to which organizations undergo change in connection with integrated reporting is contingent upon these personal attributes of senior managers.
title: Nuestro sistema de archivo, codificación y búsqueda de casos radiológicos.
Creators: name: Sales Fernandez, Covadonga
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Computer Applications-General
subject: MR
subject: Computer applications

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Desarrollar un sistema de archivo radiológico de casos interesantes prestando especial atención a que la introducción de los datos y la codificación sean tan sencillas que invite a usarlo y permita facilmente la búsqueda de casos por múltiples...
title: PAAF de adenopatías supraclaviculares para el diagnóstico de la neoplasia de pulmón.
Creators: name: Sanchis Querol, Eduard
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Puncture
subject: Biopsy
subject: Ultrasound
subject: CT
subject: Respiratory system

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Evaluar la utilidad de la PAAF de adenopatías supraclaviculares en el diagnóstico de la neoplasia de...
The origin and tectonic evolution of the Annieopsquotch ophiolite belt, Newfoundland Appalachians
Creators: name: Lissenberg, Cornelis Johannes
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Geology.

description: The Annieopsquotch Accretionary Tract comprises a series of arc-back arc complexes and ophiolites that formed in lapetus Ocean and were accreted to the composite Laurentian margin, providing a unique view of tectonic processes operating during the Ordovician Taconic orogeny. The Annieopsquotch ophiolite belt, the oldest and structurally highest complex, preserves three magmatic episodes, and formed during initiation of west-directed subduction. It thus records the formation of the subduction zone that was responsible for formation of the units preserved in the Annieopsquotch Accretionary Tract. The Annieopsquotch ophiolite belt was accreted to the Laurentian margin prior to 470 Ma along the sinistral-oblique Lloyds River Fault Zone. The Lloyds River Fault Zone was intruded syn-kinematically by two plutonic suites (464-459 Ma), which triggered renewed deformation at high temperatures, illustrating that a positive feedback between deformation and magmatism facilitates the transfer of oceanic complexes to continental margins. Age constraints indicate that the majority of the Annieopsquotch Accretionary Tract was accreted 5 to 10 Ma after formation of the units, illustrating that complexities of accretionary tectonics in lapetus were similar to those in Mesozoic to recent accretionary orogens. In contrast to other accretionary orogens, the role of fore-arc accretion was limited, whereas recycled continental basement played an important role. Syn-kinematic plutons tapped not only a sub-arc mantle source, but also a lithospheric mantle and crustal source, leading to isotopically evolved signatures. The majority of the gabbro zone of the Annieopsquotch ophiolite is composed of gabbroic cumulates with paleohorizontal intrusive contacts. These contacts have finer grain sizes and comb structures (crescumulates), suggesting they are sills. The parental magmas of cumulates in the sills had compositions very similar to the overlying sheeted dykes and basalts, and generally become more evolved up-section, indicating that magma evolution in the Annieopsquotch ophiolite was dominated by fractionation in lower crustal conduits. The parental magmas of the gabbros, sheeted dykes, and basalts preserve a similar, wide range of compositions, indicating that aggregation, homogenization, and fractionation in an axial melt lens was inefficient. Lower crustal accretion was thus dominated by intrusion of melts from below, rather than remobilization of cumulates from above.
A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents
Creators: name: Dodsworth, Thomas
name: Kim, David D.
name: Procyshyn, Ric M. (Ric Michael), 1961-
name: Ross, Colin J.
name: Honer, William G. (William George), 1957-
name: Barr, Alasdair M.
Publisher: name: BioMed Central
Year: 2018

description: The second generation antipsychotic drug risperidone is widely used in the field of child and adolescent psychiatry to treat conditions associated with disruptive behavior, aggression and irritability, such as autism spectrum disorders. While risperidone can provide symptomatic relief for many patients, there is considerable individual variability in the therapeutic response and side-effect profile of the medication. One well established biological factor that contributes to these individual differences is genetic variation in the cytochrome P450 enzyme 2D6. The 2D6 enzyme metabolizes risperidone and therefore affects drug levels and dosing. In the present review, we summarize the current literature on 2D6 variants and their effects on risperidone responses, specifically in children and adolescents. Relevant articles were identified through systematic review, and after irrelevant articles were discarded, ten studies were included in the review. Most prospective studies were well controlled, but often did not have a large enough sample size to make robust statements about rarer variants, including those categorized as ultra-rapid and poor metabolizers. Individual studies demonstrated a role for different genetic variants in risperidone drug efficacy, pharmacokinetics, hyperprolactinemia, weight gain, extrapyramidal symptoms and drug–drug interactions. Where studies overlapped in measurements, there was typically a consensus between results. These findings indicate that the value of 2D6 genotyping in the youth population treated with risperidone requires further study, in particular with the less common variants.