cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome
Creators: name: Wang, Zefeng
name: Li, Ronghui
name: Zeng, Xin
name: Keles, Sunduz
name: Li, Hongda
name: Dong, Qiping
name: Yuan, Xinni
name: Zhao, Xinyu
name: Gao, Yu
name: Chiao, Cassandra
name: Chang, Qiang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Mutations in the human MECP2 gene cause Rett syndrome (RTT), a severe neurodevelopmental disorder that predominantly affects girls. Despite decades of work, the molecular function of MeCP2 is not fully understood. Here we report a systematic identification of MeCP2-interacting proteins in the mouse brain. In addition to transcription regulators, we found that MeCP2 physically interacts with several modulators of RNA splicing, including LEDGF and DHX9. These interactions are disrupted by RTT causing mutations, suggesting that they may play a role in RTT pathogenesis. Consistent with the idea, deep RNA sequencing revealed misregulation of hundreds of splicing events in the cortex of Mecp2 knockout mice. To reveal the functional consequence of altered RNA splicing due to the loss of MeCP2, we focused on the regulation of the splicing of the flip/flop exon of Gria2 and other AMPAR genes. We found a significant splicing shift in the flip/flop exon toward the flop inclusion, leading to a faster decay in the AMPAR gated current and altered synaptic transmission. In summary, our study identified direct physical interaction between MeCP2 and splicing factors, a novel MeCP2 target gene, and established functional connection between a specific RNA splicing change and synaptic phenotypes in RTT mice. These results not only help our understanding of the molecular function of MeCP2, but also reveal potential drug targets for future therapies.
Tailoring optical response of a hybrid comprising a quantum dimer emitter strongly coupled to a metal nanoparticle
Creators: name: Nugroho, Bintoro S.
name: Malyshev, Victor A.
name: Knoester, Jasper
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study theoretically the optical response of a nanohybrid comprising a symmetric quantum dimer emitter coupled to a metal nanoparticle (MNP). The interactions between the exitonic transitions in the dimer and the plasmons in the MNP lead to novel effects in the composite's input-output characteristics for the light intensity and the absorption spectrum, which we study in the linear and nonlinear regimes. We fnd that the exciton-plasmon hybridization leads to optical bistability and hysteresis for the one-exciton transition and enhancement of excitation for the two-exciton transition. The latter leads to a signifcant decrease of the field strength needed to saturate the system. In the linear regime, the absortion spectrum has a dispersive (Fano-like) line shape. The spectral position and shape of this spectrum depend on the detuning of the dimer's one-exciton resonance relative to the plasmon resonance. Upon increasing the applied field intensity to the nonlinear regime, the Fano-like singularities in the absorption spectra are smeared and they disappear due to the saturation of the dimer, which leads to the MNP dominating the spectrum. The above effects, for which we provide physical explanations, allow one to tailor the Fano-like shape of the absorption spectrum, by changing either the detuning or the input power.
American End of World Beliefs and Environmental Concern
Creators: name: Billet, Matthew
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: This study is meant to replicate and extend our previous findings using a representative sample from the USA. In previous studies, we’ve found that participants who believe the end of the world will be caused by climate change diverged on a number of measures from those that believe in the world ending via judgment day. In general terms, they diverged in how they conceptualized the end of the world, which may have downstream consequences for their attitudes and behaviours towards the environment and their views towards having children. Beyond testing the replicability of these patterns of results, we also seek to understand the association between end of world beliefs and well-being.
Entropy determination for mixtures in the adiabatic grand-isobaric ensemble
Creators: name: Desgranges, Caroline
name: Delhommelle, Jerome
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The entropy change that occurs upon mixing two fluids has remained an intriguing topic since the dawn of statistical mechanics. In this work, we generalize the grand-isobaric ensemble to mixtures, and develop a Monte Carlo algorithm for the rapid determination of entropy in these systems. A key advantage of adiabatic ensembles is the direct connection they provide with entropy. Here, we show how the entropy of a binary mixture A-B can be readily obtained in the adiabatic grand-isobaric $(μ_{\text{A}}$, $μ_{\text{B}}, P, R)$ ensemble, in which $μ_{\text{A}}$ and $μ_{\text{B}}$ denote the chemical potential of components A and B, respectively, $P$ is the pressure, and $R$ is the heat (Ray) function, that corresponds to the total energy of the system. This, in turn, allows for the evaluation of the entropy of mixing, as well as of the Gibbs free energy of mixing. We also demonstrate that our approach performs very well both on systems modeled with simple potentials and with complex many-body force fields. Finally, this approach provides a direct route to the determination of the thermodynamic properties of mixing, and allows for the efficient detection of departures from ideal behavior in mixtures.
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
Creators: name: Yau, Michelle S.
name: Lane, Nancy E.
name: Barrett-Connor, Elizabeth
name: Valdes, Ana M.
name: Lafeber, Floris
name: Muir, Kenneth
name: Evans, Dan S.
name: Boer, Cindy G.
name: Nelissen, Rob G. H. H.
name: Uitterlinden, Andre G.
name: Kraus, Virginia B.
name: Zhang, Weiya
name: van Rooij, Jeroen
name: Rivadeneira, Fernando
name: Styrkarsdottir, Unnur
name: Kloppenburg, Margreet
name: Metrustry, Sarah
name: Castaño-Betancourt, Martha C.
name: Hart, Deborah J.
name: Ramos, Yolande F. M.
name: Doherty, Michael
name: Spector, Tim D.
name: Meulenbelt, Ingrid
name: Doherty, Sally
name: Liu, Youfang
name: Jordan, Joanne M.
name: Hofman, Albert
name: Kraaij, Robert
name: Evangelou, Evangelos
name: Nevitt, Michael C.
name: den Hollander, Wouter
name: van Meurs, Joyce B. J.
name: Zeggini, Eleftheria
name: Slagboom, Eline P.
name: Arden, Nigel
name: Mitchell, Braxton D.
name: Maciewicz, Rose A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts. We identified five genome-wide significant (GWS, P≤5·0×10−8) SNPs annotated to four distinct loci. In addition, we found two additional loci that were significantly replicated, but results of combined meta-analysis fell just below the genome wide significance threshold. The four novel associated genetic loci were located in/near TGFA (rs2862851), PIK3R1 (rs10471753), SLBP/FGFR3 (rs2236995), and TREH/DDX6 (rs496547), while the other two (DOT1L and SUPT3H/RUNX2) were previously identified. A systematic prioritization for underlying causal genes was performed using diverse lines of evidence. Exome sequencing data (n = 2,050 individuals) indicated that there were no rare exonic variants that could explain the identified associations. In addition, TGFA, FGFR3 and PIK3R1 were differentially expressed in OA cartilage lesions versus non-lesioned cartilage in the same individuals. In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human OA, which may serve as a new target for future therapies.
title: A systematic review and meta-analysis of the impact of the COVID-19 pandemic on learning (LIEPP Working Paper, n°134)
Creators: name: Betthäuser, Bastian A.
name: Bach-Mortensen, Anders
name: Engzell, Per
Publisher: name: Sciences Po - LIEPP
Year: 2022
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: How has the COVID-19 pandemic affected learning progress among school-age children? Two years after the onset of the pandemic, a growing number of studies have addressed this question, but findings vary depending on context. We conduct a pre-registered systematic review, quality appraisal and meta-analysis of 34 studies across 12 countries to assess the magnitude of the effect of the pandemic on learning and the role of different factors in moderating this effect. We find a significant overall learning deficit early in the pandemic (Cohen's d =-0.17, 95 c.i.-0.22,-0.13), which persists over time. Forgone learning was particularly large among children from low socioeconomic backgrounds and in contexts with high excess mortality, longer school closures, and less-developed digital learning infrastructures. Future research should assess the effects of the COVID-19 pandemic in low and middle-income countries, as existing studies mainly focus on high-income countries.
The Effectiveness Investigation of Evaporative Cooling Using Radiator for Pre-Cooling System
Creators: name: Srithorn Aupakham
Publisher: name: Rajamangala University of Technology Lanna
Year: 2018
Subjects: Evaporative Cooling
Radiator
Pre-Cooling

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 12, 2, 1-9
Two-dimensional germanium islands with Dirac signature on Ag2Ge surface alloy
Creators: name: Deng, Jiaqi
name: Ablat, Gulnigar
name: Yang, Yumu
name: Fu, Xiaoshuai
name: Wu, Qilong
name: Li, Ping
name: Zhang, Li
name: Safaei, Ali
name: Zhang, Lijie
name: Qin, Zhihui
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Two-dimensional (2D) Dirac materials have attracted intense research efforts due to their promise for applications ranging from field-effect transistors and low-power electronics to fault-tolerant quantum computation. One key challenge is to fabricate 2D Dirac materials hosting Dirac electrons. Here, monolayer germanene is successfully fabricated on a Ag2Ge surface alloy. Scanning tunneling spectroscopy measurements revealed a linear energy dispersion relation. The latter was supported by density functional theory calculations. These results demonstrate that monolayer germanene can be realistically fabricated on a Ag2Ge surface alloy. The finding opens the door to exploration and study of 2D Dirac material physics and device applications.
Decentralized Search and Track with Multiple Autonomous Agents
Creators: name: Papaioannou, Savvas
name: Kolios, Panayiotis
name: Theocharides, Theocharis
name: Panayiotou, Christos G.
name: Polycarpou, Marios M.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper we study the problem of cooperative searching and tracking (SAT) of multiple moving targets with a group of autonomous mobile agents that exhibit limited sensing capabilities. We assume that the actual number of targets is not known a priori and that target births/deaths can occur anywhere inside the surveillance region. For this reason efficient search strategies are required to detect and track as many targets as possible. To address the aforementioned challenges we augment the classical Probability Hypothesis Density (PHD) filter with the ability to propagate in time the search density in addition to the target density. Based on this, we develop decentralized cooperative look-ahead strategies for efficient searching and tracking of an unknown number of targets inside a bounded surveillance area. The performance of the proposed approach is demonstrated through simulation experiments.
การศึกษาเชิงทดลองการเพิ่มประสิทธิภาพแผงเซลล์แสงอาทิตย์โดยใช้ท่อความร้อนแบบแบน
Creators: name: อนุรัตน์  เทวตา
Publisher: name: มหาวิทยาลัยเทคโนโลยีราชมงคลล้านนา
Year: 2018
Subjects: การเพิ่มประสิทธิภาพ, แผงเซลล์แสงอาทิตย์, ท่อความร้อนแบบแบน

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 12, 2, 83-94
title: Dynamic CT Assessment of Distal Radioulnar Instability
Creators: name: Srikanthan, Ahagasthikan
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2016
Subjects: subject: Trauma
subject: Education and training
subject: Diagnostic procedure
subject: CT
subject: Musculoskeletal joint

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To understand and apply the different radiological techniques for assessing Distal Radioulnar Joint instability using standard radiographs, MRI, ultrasound and dynamic CT...
Cliques in dense inhomogeneous random graphs
Creators: name: Doležal, Martin
name: Hladký, Jan
name: Máthé, András
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: The theory of dense graph limits comes with a natural sampling process which yields an inhomogeneous variant G(n,W) of the Erdos-Renyi random graph. Here we study the clique number of these random graphs. We establish the concentration of the clique number of G(n,W) for each fixed n, and give examples of graphons for which G(n,W) exhibits wild long-term behavior. Our main result is an asymptotic formula which gives the almost sure clique number of these random graphs. We obtain a similar result for the bipartite version of the problem. We also make an observation that might be of independent interest: Every graphon avoiding a fixed graph is countably-partite.
description: 30 pages, 2 figure; accepted to publication in Random Structures and Algorithms
Probabilistic Search and Track with Multiple Mobile Agents
Creators: name: Papaioannou, Savvas
name: Kolios, Panayiotis
name: Theocharides, Theocharis
name: Panayiotou, Christos G.
name: Polycarpou, Marios M.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper we are interested in the task of searching and tracking multiple moving targets in a bounded surveillance area with a group of autonomous mobile agents. More specifically, we assume that targets can appear and disappear at random times inside the surveillance region and their positions are random and unknown. The agents have a limited sensing range, and due to sensor imperfections they receive noisy measurements from the targets. In this work we utilize the theory of random finite sets (RFS) to capture the uncertainty in the time-varying number of targets and their states and we propose a decision and control framework, in which the mode of operation (i.e. search or track) as well as the mobility control action for each agent, at each time instance, are determined so that the collective goal of searching and tracking is achieved. Extensive simulation results demonstrate the effectiveness and performance of the proposed solution.
Recombination Rate Heterogeneity within Arabidopsis Disease Resistance Genes
Creators: name: Griffin, Catherine
name: Zhao, Xiaohui
name: McVean, Gil
name: Hardcastle, Thomas J.
name: Jackson, Matthew
name: Copenhaver, Gregory P.
name: Ziolkowski, Piotr A.
name: Underwood, Charles J.
name: Choi, Kyuha
name: Henderson, Ian R.
name: Mézard, Christine
name: Serra, Heïdi
name: Yelina, Nataliya E.
name: Reinhard, Carsten
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Meiotic crossover frequency varies extensively along chromosomes and is typically concentrated in hotspots. As recombination increases genetic diversity, hotspots are predicted to occur at immunity genes, where variation may be beneficial. A major component of plant immunity is recognition of pathogen Avirulence (Avr) effectors by resistance (R) genes that encode NBS-LRR domain proteins. Therefore, we sought to test whether NBS-LRR genes would overlap with meiotic crossover hotspots using experimental genetics in Arabidopsis thaliana. NBS-LRR genes tend to physically cluster in plant genomes; for example, in Arabidopsis most are located in large clusters on the south arms of chromosomes 1 and 5. We experimentally mapped 1,439 crossovers within these clusters and observed NBS-LRR gene associated hotspots, which were also detected as historical hotspots via analysis of linkage disequilibrium. However, we also observed NBS-LRR gene coldspots, which in some cases correlate with structural heterozygosity. To study recombination at the fine-scale we used high-throughput sequencing to analyze ~1,000 crossovers within the RESISTANCE TO ALBUGO CANDIDA1 (RAC1) R gene hotspot. This revealed elevated intragenic crossovers, overlapping nucleosome-occupied exons that encode the TIR, NBS and LRR domains. The highest RAC1 recombination frequency was promoter-proximal and overlapped CTT-repeat DNA sequence motifs, which have previously been associated with plant crossover hotspots. Additionally, we show a significant influence of natural genetic variation on NBS-LRR cluster recombination rates, using crosses between Arabidopsis ecotypes. In conclusion, we show that a subset of NBS-LRR genes are strong hotspots, whereas others are coldspots. This reveals a complex recombination landscape in Arabidopsis NBS-LRR genes, which we propose results from varying coevolutionary pressures exerted by host-pathogen relationships, and is influenced by structural heterozygosity.
Application of Kansei Engineering and DEMATEL to Prioritize Service Quality for Public Hospital in Thailand
Creators: name: Chaiwat  Kittidecha
Publisher: name: Rajamangala University of Technology Lanna
Year: 2018
Subjects: Kansei Engineering
DEMATEL
Service Quality
Thailand Public Hospitals

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 12, 2, 103-114
title: Compétences socio-comportementales, réussite académique et inégalités socio-économiques (LIEPP Working Paper, n°113)
Creators: name: Maximino Pinheiro, Mélanie
Publisher: name: Sciences Po - LIEPP
Year: 2020
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Ce document se veut être un support guidant les futurs projets portés par l'axe Politiques éducatives du Laboratoire Interdisciplinaire d'Evaluation des Politiques Publiques (LIEPP) autour du thème de recherche « Apprentissages et compétences socio-comportementales » chez les enfants. Ne pouvant couvrir toutes les compétences existantes et toutes leurs sous-dimensions, nous nous sommes particulièrement intéressés aux plus prédictives de la réussite académique et à celles qui pouvaient être le plus socialement biaisées. Le choix des compétences traitées s'appuie également sur les thématiques de recherche privilégiées des membres de l axe et s’inscrit dans le cadre du récent redéploiement du LIEPP en collaboration avec Université de Paris. Trois synthèses sont ainsi proposées portant respectivement sur les compétences non-cognitives (dites aussi socio- émotionnelles) telles que l'engagement, le contrôle de soi ou les compétences sociales ; les fonctions exécutives et plus particulièrement l'inhibition, la mise à jour en mémoire de travail et la flexibilité cognitive ; et enfin la métacognition.
On the quasinormal modes in generalized Nariai spacetimes
Creators: name: Venâncio, Joás
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Quasinormal modes are eigenmodes of dissipative systems. For instance, if a spacetime with an event or cosmological horizon is perturbed from its equilibrium state, quasinormal modes arise as damped oscillations with a spectrum of complex frequencies, called quasinormal frequencies, that depends just on the charges which define the geometry of the spacetime in which the perturbation is propagating, such as the mass, electric charge, and angular momentum. Mathematically, this discrete spectrum of quasinormal modes stems from the fact that certain boundary conditions must be imposed to the physical fields propagating in such a spacetime. In this thesis, we shall consider a higher-dimensional generalization of the charged Nariai spacetime that is comprised of the direct product of the two-dimensional de Sitter space, $dS_2$, with an arbitrary number of two-spheres, $S^2$, and investigate the dynamics of spin-$s$ field perturbations for $s = 0, 1/2, 1$ and $2$. The boundary conditions leading to quasinormal modes are analyzed and the quasinormal frequencies are analytically obtained.
description: 114 pages, 7 figures. arXiv admin note: text overlap with arXiv:1804.05953
Sotorasib: A Review in KRAS G12C Mutation-Positive Non-Small Cell Lung Cancer
Creators: name: Lee, Arnold
Publisher: name: Adis Journals
Year: 2022
Subjects: subject: Medicine
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Arnold Lee is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
 Additional information about this Adis Drug Review can be found here.
 Abstract  Sotorasib (LUMAKRAS™ in the USA and LUMYKRAS™ in the EU) is an orally active, first-in-class G12C-mutant KRAS (KRASG12C) inhibitor. By binding irreversibly to KRASG12C, sotorasib inhibits downstream signalling pathways which are associated with cell growth and differentiation. Sotorasib is indicated for the treatment of adults with advanced, previously treated, KRAS G12C mutation-positive non-small cell lung cancer (NSCLC) in multiple countries, including the countries of the EU and the USA. A clinically relevant objective response rate was observed in patients with KRAS G12C mutation-positive NSCLC during the primary analysis and in an updated analysis of the phase I/II CodeBreaK 100 trial. Furthermore, a clinically relevant response duration was reported in updated analyses of the trial. Sotorasib has a manageable tolerability profile, with permitted dose modifications to manage toxicity. In summary, sotorasib is a promising KRASG12C inhibitor that increases the available treatment options for patients with KRAS G12C mutation-positive NSCLC who were previously treated with platinum-based chemotherapy and/or immunotherapy.
 © Springer Nature Switzerland AG 2022
The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts
Creators: name: Mieczkowski, Piotr A.
name: Malc, Ewa P.
name: Klimczak, Leszek J.
name: Dai, Shuangshuang
name: Gordenin, Dmitry A.
name: Grimm, Sara A.
name: Fargo, David C.
name: Chan, Kin
name: Cortes-Ciriano, Isidro
name: Roberts, Steven A.
name: Taylor, Jack A.
name: Schurman, Shepherd H.
name: Saini, Natalie
name: Kaufmann, William K.
name: Park, Peter J.
name: Boyer, Jayne C.
name: Lee, Eunjung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and improving the prognosis and prevention of cancers and other genetic diseases. Previous methods relying on either the generation of induced pluripotent stem cells, or sequencing of single-cell genomes were inherently error-prone and did not allow independent validation of the mutations. In the current study we eliminated these potential sources of error by high coverage genome sequencing of single-cell derived clonal fibroblast lineages, obtained after minimal propagation in culture, prepared from skin biopsies of two healthy adult humans. We report here accurate measurement of genome-wide magnitude and spectra of mutations accrued in skin fibroblasts of healthy adult humans. We found that every cell contains at least one chromosomal rearrangement and 600–13,000 base substitutions. The spectra and correlation of base substitutions with epigenomic features resemble many cancers. Moreover, because biopsies were taken from body parts differing by sun exposure, we can delineate the precise contributions of environmental and endogenous factors to the accrual of genetic changes within the same individual. We show here that UV-induced and endogenous DNA damage can have a comparable impact on the somatic mutation loads in skin fibroblasts.
เปรียบเทียบประสิทธิภาพการส่งกำลังไฟฟ้าระหว่างหม้อแปลงแกนอากาศและหม้อแปลงแกนเหล็กของวงจรขยายกำลังคลาสอี
Creators: name: มุหัมมัด มั่นศรัทธา
Publisher: name: มหาวิทยาลัยนราธิวาสราชนครินทร์
Year: 2018
Subjects: หม้อแปลงแกนเหล็ก
หม้อแปลงแกนอากาศ
วงจรขยายสัญญาณคลาสอี
ส่งกำลังไฟฟ้า

description: วารสารวิชาการและวิจัย มทร.พระนคร สาขาวิทยาศาสตร์และเทคโนโลยี, 12, 2, 115-122
title: Imaging of polymyalgia rheumatica: what the radiologist should know
Creators: name: Leao, Renata
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2016
Subjects: subject: Education
subject: Diagnostic procedure
subject: Ultrasound
subject: PET-CT
subject: MR
subject: Musculoskeletal system
subject: Musculoskeletal joint
subject: Inflammation

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: Illustrate the cases of Polymyalgia Rheumatica emphasizing the imaging findings that may contribute for its specific diagnosis Illustrate the clinical set and the main image patterns that should make the radiologist think of PMR Illustrate the main...
title: Des inégalités répertoriées : les (dé)valorisations genrées des emplois de soutien à la recherche (LIEPP Working Paper, n°135)
Creators: name: Bouchet, Célia
Publisher: name: Sciences Po - LIEPP
Year: 2022
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Alors qu'un écart de salaire substantiel existe entre le personnel masculin et féminin de soutien à la recherche, les inégalités professionnelles entre les sexes demeurent moins étudiées pour leur groupe que pour les chercheurs et chercheuses. En contribution à ce programme, cet article mobilise une approche d'équité salariale et une perspective d'action publique pour examiner les écarts de valorisation entre des emplois et des branches d’activité de soutien à la recherche ayant différents taux de féminisation. Nous utilisons des statistiques bivariées et des régressions pour analyser les descriptions des 242 emplois-types de soutien à la recherche classifiés dans RéFérens III, un répertoire ministériel. RéFérens III reproduit plusieurs inégalités salariales au détriment des emplois les plus féminisés : en manquant de revaloriser deux diplômes typiquement féminins ; en sous-repérant certaines compétences au sein des branches d’activité à dominante féminine ; et/ou en omettant d’échelonner les compétences dans lesdites branches. Ces résultats éclairent certains ressorts des inégalités entre les sexes parmi les métiers de soutien à la recherche, tout en ouvrant des réflexions sur les enjeux intersectionnels de l’approche d’équité salariale et sur les défis du dialogue entre recherche et action publique devant le « genre des politiques ».
description: While a substantial wage gap exists between male and female research support staff, gender professional inequalities have been less studied for their group than for male and female researchers. As a contribution to this program, this article mobilizes a pay equity approach and a policy perspective to examine valuation gaps among research support jobs and fields of activity with different feminization rates. We use bivariate statistics and regressions to analyze descriptions of the 242 typical jobs listed by RéFérens III, a classification conceived by the Ministry. RéFérens III reproduces several wage inequalities to the detriment of the most feminized jobs: by failing to upgrade two typically female diplomas; by underrecognizing certain skills within female-dominated fields; and/or by omitting to scale the skills within these fields. These findings shed light on some of the mechanisms of gender inequalities among research support staff, while also prompting reflections on the intersectional issues of the pay equity approach and on the challenges in the research-policy dialogue regarding the "gender of policies".
Spectral determination of the colour and vertical structure of dark spots in Neptune's atmosphere
Creators: name: Irwin, Patrick G. J.
name: Dobinson, Jack
name: Wong, Arjuna James. Michael H.
name: Fletcher, Leigh N.
name: Roman, Michael T.
name: Teanby, Nicholas A.
name: Toledo, Daniel
name: Orton, Glenn S.
name: Perez-Hoyos, Santiago
name: Sanchez-Lavega, Agustin
name: Sromovsky, Lawrence
name: Simon, Amy A.
name: Morales-Juberias, Raul
name: de Pater, Imke
name: Cook, Statia L.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Previous observations of dark vortices in Neptune's atmosphere, such as Voyager-2's Great Dark Spot, have been made in only a few, broad-wavelength channels, which has hampered efforts to pinpoint their pressure level and what makes them dark. Here, we present Very Large Telescope (Chile) MUSE spectrometer observations of Hubble Space Telescope's NDS-2018 dark spot, made in 2019. These medium-resolution 475 - 933 nm reflection spectra allow us to show that dark spots are caused by a darkening at short wavelengths (< 700 nm) of a deep ~5-bar aerosol layer, which we suggest is the H$_2$S condensation layer. A deep bright spot, named DBS-2019, is also visible on the edge of NDS-2018, whose spectral signature is consistent with a brightening of the same 5-bar layer at longer wavelengths (> 700 nm). This bright feature is much deeper than previously studied dark spot companion clouds and may be connected with the circulation that generates and sustains such spots.
description: 1 table. 3 figures. Nature Astronomy (2023)
The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1
Creators: name: Cunin, Pierre
name: Okada, Yukinori
name: Wu, Di
name: Yang, Yu
name: Li, Gang
name: Nigrovic, Peter A.
name: Plenge, Robert M.
name: Diogo, Dorothée
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of how these variants alter gene function. The non-coding triallelic dinucleotide polymorphism CCR6DNP is associated with risk for rheumatoid arthritis, and is considered likely causal because allelic variation correlates with expression of the chemokine receptor CCR6. Using transcription activator-like effector nuclease (TALEN) gene editing, we confirmed that CCR6DNP regulates CCR6. To identify the associated transcription factor, we applied a novel assay, Flanking Restriction Enhanced Pulldown (FREP), to identify specific association of poly (ADP-ribose) polymerase 1 (PARP-1) with CCR6DNP consistent with the established allelic risk hierarchy. Correspondingly, manipulation of PARP-1 expression or activity impaired CCR6 expression in several lineages. These findings show that CCR6DNP is a causal variant through which PARP-1 regulates CCR6, and introduce a highly efficient approach to interrogate non-coding genetic polymorphisms associated with human disease.
LHC Phenomenology of the Type II Seesaw Mechanism: Observability of Neutral Scalars in the Nondegenerate Case
Creators: name: Han, Zhi-Long
name: Ding, Ran
name: Liao, Yi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: This is a sequel to our previous work on LHC phenomenology of the type II seesaw model in the nondegenerate case. In this work, we further study the pair and associated production of the neutral scalars H^0/A^0. We restrict ourselves to the so-called negative scenario characterized by the mass order M_{H^{\pm\pm}}>M_{H^\pm}>M_{H^0/A^0}, in which the H^0/A^0 production receives significant enhancement from cascade decays of the charged scalars H^{\pm\pm},~H^\pm. We consider three important signal channels---b\bar{b}γγ, b\bar{b}τ^+τ^-, $b\bar{b}\ell^+\ell^-\cancel{E}_T$---and perform detailed simulations. We find that at the 14 TeV LHC with an integrated luminosity of 3000/fb, a 5σmass reach of 151, 150, and 180 GeV, respectively, is possible in the three channels from the pure Drell-Yan H^0A^0 production, while the cascade-decay-enhanced H^0/A^0 production can push the mass limit further to 164, 177, and 200 GeV. The neutral scalars in the negative scenario are thus accessible at LHC run II.
description: v1: 32 pages, 17 figures, 3 tables. v2: added 2 refs (2nd in [61] and [66]), revised Acknowledgments, and corrected grammatical errors according to proofs; no other changes
title: Ultrasound, Elastosonography, Functional and Visual Evaluation of the Outcome of Repetitive Muscle Magnetic Stimulation
Creators: name: Forzoni, Leonardo
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2016
Subjects: subject: Tissue characterisation
subject: Image verification
subject: Treatment effects
subject: Diagnostic procedure
subject: Ultrasound
subject: Elastography
subject: Musculoskeletal system
subject: Musculoskeletal soft tissue

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Evaluation of repetitive Muscle Magnetic Stimulation (rMMS) effects on functional status and quality of life after knee surgery. Ultrasound (US) and Elastosonography, as well as Visual Analog Scale (VAS), Maximal Voluntary Contraction (MVC) and...
KN V 52 : a late Minoan II reference to Athena and Poseidon
Creators: name: Walsh, Kathryn Elizabeth, 1969-
Publisher: name: The University of Texas at Austin
Year: 1995
Subjects: subject: KN V 52
subject: Room of the Chariot Tablets
subject: Knossos
subject: Theonyms
subject: Linear B inscriptions
subject: Ancient tablets
subject: Athena in inscriptions
subject: Poseidon in inscriptions
subject: Classical deities
subject: Crete
subject: Greece
subject: History
subject: Late Minoan II
subject: LM II
subject: Greek religious continuity
subject: Ancient religious continuity
subject: Classical Greek religious continuity
subject: Ancient religious history
subject: Inscriptions--Greece--Knossos (Extinct city)
subject: Heraclean tablets
subject: Athena (Greek deity)--In literature--History
subject: Poseidon (Greek deity)--In literature--History
subject: Knossos (Extinct city)--Religious life and customs
subject: Greece--Religious life and customs--History
subject: Mythology, Classical--Greece--History

description: The tablet KN V 52, from the Room of the Chariot Tablets (RCT) deposit at Knossos, contains a list of Linear B sign groups unlike any other from the RCT deposit. The sign groups on KN V 52 have been explained as theonyms based on the presence of a-ta-na-po-ti-ni-ja and po-se-da[-o-ne which are interpreted as the deities Athena and Poseidon. KN V 52 is unique within the RCT because no other tablet from the deposit lists theonyms. The archaeological context for KN V 52 and its deposit is also unusual. The RCT dates to the Late Minoan II period (LM II) on Crete, c. 1450 B. C. E., which is an early date for the presence of Linear B on Crete. This find-context tells us that the divinities who became Athena and Poseidon were already being recorded in LM 11. So the theonyms on this tablet have considerable bearing on the larger issue of religious continuity in the Greek world. In fact, on the basis of this tablet, I shall argue for elements of a continuing tradition of religious practice from LM II in the Bronze Age through the Dark Ages and into the Classical era. In discussing the theme of continuity of religious practice from the Bronze Age, I begin with an examination of the evidence for Classical Greek deities who are first recorded in the Bronze Age. This discussion will focus largely on the appearance of Athena and Poseidon on KN V 52 and the context of this tablet, though I will also put the other theonyms on the tablet into context. In addition, as a part of this discussion of the Bronze Age evidence, I will include the names of other deities which existed at that time and also appear in Classical Greek religion. Then, in the second part of this study, I will examine what social, economic, and religious elements from the Bronze Age can be traced through the Dark Ages. In conclusion, I will examine Homeric and other, later references to Athena and Poseidon to determine what a knowledge of their Homeric and Classical attributes may tell us about their association in the Bronze Age
A genetic switch controls the production of flagella and toxins in Clostridium difficile
Creators: name: Anjuwon-Foster, Brandon R.
name: Tamayo, Rita
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: In the human intestinal pathogen Clostridium difficile, flagella promote adherence to intestinal epithelial cells. Flagellar gene expression also indirectly impacts production of the glucosylating toxins, which are essential to diarrheal disease development. Thus, factors that regulate the expression of the flgB operon will likely impact toxin production in addition to flagellar motility. Here, we report the identification a “flagellar switch” that controls the phase variable production of flagella and glucosylating toxins. The flagellar switch, located upstream of the flgB operon containing the early stage flagellar genes, is a 154 bp invertible sequence flanked by 21 bp inverted repeats. Bacteria with the sequence in one orientation expressed flagellum and toxin genes, produced flagella, and secreted the toxins (“flg phase ON”). Bacteria with the sequence in the inverse orientation were attenuated for flagellar and toxin gene expression, were aflagellate, and showed decreased toxin secretion (“flg phase OFF”). The orientation of the flagellar switch is reversible during growth in vitro. We provide evidence that gene regulation via the flagellar switch occurs post-transcription initiation and requires a C. difficile-specific regulatory factor to destabilize or degrade the early flagellar gene mRNA when the flagellar switch is in the OFF orientation. Lastly, through mutagenesis and characterization of flagellar phase locked isolates, we determined that the tyrosine recombinase RecV, which catalyzes inversion at the cwpV switch, is also responsible for inversion at the flagellar switch in both directions. Phase variable flagellar motility and toxin production suggests that these important virulence factors have both advantageous and detrimental effects during the course of infection.
Designing, Synthesizing and Modeling Active Fluids
Creators: name: Essafri, Ilham
name: Ghosh, Bappa
name: Desgranges, Caroline
name: Delhommelle, Jerome
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We review recent advances in the design, synthesis, and modeling of active fluids. Active fluids have been at the center of many technological innovations and theoretical advances over the past two decades. Research on this new class of fluids has been inspired by the fascinating and remarkably efficient strategies that biological systems employ, leading to the development of biomimetic nano- and micro-machines and -swimmers. The review encompasses active fluids on both the nano- and micro-scale. We start with examples of biological active systems before we discuss how experimentalists leverage novel propulsion mechanisms to power nano- and micro-machines. We then examine how the study of these far-from-equilibrium systems has prompted the development of new simulation methods and theoretical models in nonquilibrium physics to account for their mechanical, thermodynamic and emergent properties. Recent advances in the field have paved the way for the design, synthesis, and modeling of autonomous systems at the nano- and micro-scale and open the door to the development of soft matter robotics.
Synergy of Volunteer Measurements and Volunteer Computing for Effective Data Collecting, Processing, Simulating and Analyzing on a Worldwide Scale
Creators: name: Gordienko, Nikita
name: Lodygensky, Oleg
name: Fedak, Gilles
name: Gordienko, Yuri
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The paper concerns the hype idea of "Citizen Science" and the related paradigm shift: to go from the passive "volunteer computing" to other volunteer actions like "volunteer measurements" under guidance of scientists. They can be carried out by ordinary people with standard computing gadgets (smartphone, tablet, etc.) and the various standard sensors in them. Here the special attention is paid to the system of volunteer scientific measurements to study air showers caused by cosmic rays. The technical implementation is based on integration of data about registered night flashes (by radiometric software) in shielded camera chip, synchronized time and GPS-data in ordinary gadgets: to identify night "air showers" of elementary particles; to analyze the frequency and to map the distribution of "air showers" in the densely populated cities. The project currently includes the students of the National Technical University of Ukraine "KPI", which are compactly located in Kyiv city and contribute their volunteer measurements. The technology would be very effective for other applications also, especially if it will be automated (e.g., on the basis of XtremWeb or/and BOINC technologies for distributed computing) and used in some small area with many volunteers, e.g. in local communities (Corporative/Community Crowd Computing).
description: 6 pages, 8 figures, 1 table. 38th International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO 2015); Distributed Computing, Visualization and Biomedical Engineering (DC VIS) May 25-29, 2015 (Opatija, Croatia)
Marco Jurídico en la Prevención Seguridad y Salud Ocupacional
Creators: name: Molina Delgado, José Renán
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 460102
subject: Applications in health
classificationCode: 480799
subject: Public law not elsewhere classified

description: La Constitución del Ecuador, garantiza las normas laborales, antiguamente se la conocía como la Constitución Política del Ecuador, el térmico “política”, fue suprimido ya que el mismo era considerado como el arte para gobernar
title: Imaging evaluation and exclusion of sepsis in a child presenting with a limp
Creators: name: Davies, Charlotte
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2016
Subjects: subject: Infection
subject: Education and training
subject: Diagnostic procedure
subject: Ultrasound
subject: Plain radiographic studies
subject: MR
subject: Paediatric
subject: Musculoskeletal system

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: The aim of this poster is tohighlighthow the Radiology department can assist their Peadiatric surgical and medical colleagues inexcluding sepsis as the cause of an atraumaticlimp in a child. The objectives to achieve this include: Reviewing the...
Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes
Creators: name: Richards, Emilie J.
name: Martin, Christopher H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Rapid diversification often involves complex histories of gene flow that leave variable and conflicting signatures of evolutionary relatedness across the genome. Identifying the extent and source of variation in these evolutionary relationships can provide insight into the evolutionary mechanisms involved in rapid radiations. Here we compare the discordant evolutionary relationships associated with species phenotypes across 42 whole genomes from a sympatric adaptive radiation of Cyprinodon pupfishes endemic to San Salvador Island, Bahamas and several outgroup pupfish species in order to understand the rarity of these trophic specialists within the larger radiation of Cyprinodon. 82% of the genome depicts close evolutionary relationships among the San Salvador Island species reflecting their geographic proximity, but the vast majority of variants fixed between specialist species lie in regions with discordant topologies. Top candidate adaptive introgression regions include signatures of selective sweeps and adaptive introgression of genetic variation from a single population in the northwestern Bahamas into each of the specialist species. Hard selective sweeps of genetic variation on San Salvador Island contributed 5 times more to speciation of trophic specialists than adaptive introgression of Caribbean genetic variation; however, four of the 11 introgressed regions came from a single distant island and were associated with the primary axis of oral jaw divergence within the radiation. For example, standing variation in a proto-oncogene (ski) known to have effects on jaw size introgressed into one San Salvador Island specialist from an island 300 km away approximately 10 kya. The complex emerging picture of the origins of adaptive radiation on San Salvador Island indicates that multiple sources of genetic variation contributed to the adaptive phenotypes of novel trophic specialists on the island. Our findings suggest that a suite of factors, including rare adaptive introgression, may be necessary for adaptive radiation in addition to ecological opportunity.