Additional file 2 of Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration
Creators: name: Woollacott, Ione O. C.
name: Toomey, Christina E.
name: Strand, Catherine
name: Courtney, Robert
name: Benson, Bridget C.
name: Rohrer, Jonathan D.
name: Tammaryn Lashley
Publisher: name: figshare
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Cancer
subject: 60506 Virology

description: Additional file 2: Supplementary Fig. 4. Heat map of comparisons of microglial burden between all groups and between grey and white matter within each group. a and b: CD68-positive microglia; c and d: CR3/43-positive microglia; e and f: Iba1-positive microglia. Frontal lobe: a, c, e. Temporal lobe: b, d, f. P values are presented in each box and represent results of comparisons between groups listed on corresponding vertical versus horizontal axes. The colour of each box represents the degree of statistical significance in the difference between groups, with red indicating a highly significant difference, blue a non-significant difference and white borderline (trend) or moderately significant difference, with gradations in between. FG = frontal grey matter; FW = frontal white matter; TG = temporal grey matter; TW = temporal white matter. Supplementary Fig. 5. Heat map of comparisons of microglial circularity between all groups and between grey and white matter within each group. a and b: CD68-positive microglia; c and d: CR3/43-positive microglia; e and f: Iba1-positive microglia. Frontal lobe: a, c, e. Temporal lobe: b, d, f. P values are presented in each box and represent results of comparisons between groups listed on corresponding vertical versus horizontal axes. The colour of each box represents the degree of statistical significance in the difference between groups, with red indicating a highly significant difference, blue a non-significant difference and white borderline (trend) or moderately significant difference, with gradations in between. FG = frontal grey matter; FW = frontal white matter; TG = temporal grey matter; TW = temporal white matter. Supplementary Fig. 6. Heat map of comparisons of microglial perimeter between all groups and between grey and white matter within each group. a and b: CD68-positive microglia; c and d: CR3/43-positive microglia; e and f: Iba1-positive microglia. Frontal lobe: a, c, e. Temporal lobe: b, d, f. P values are presented in each box and represent results of comparisons between groups listed on corresponding vertical versus horizontal axes. The colour of each box represents the degree of statistical significance in the difference between groups, with red indicating a highly significant difference, blue a non-significant difference and white borderline (trend) or moderately significant difference, with gradations in between. FG = frontal grey matter; FW = frontal white matter; TG = temporal grey matter; TW = temporal white matter. Supplementary Fig. 7. Heat map of comparisons of microglial dystrophy scores between all groups and between grey and white matter within each group. a frontal lobe; b temporal lobe. P values are presented in each box and represent results of comparisons between groups listed on corresponding vertical versus horizontal axes. The colour of each box represents the degree of statistical significance in the difference between groups, with red indicating a highly significant difference, blue a non-significant difference and white borderline (trend) or moderately significant difference, with gradations in between. FG = frontal grey matter; FW = frontal white matter; TG = temporal grey matter; TW = temporal white matter.