cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Predicting the Potential Habitat of Three Endangered Species of Carpinus Genus under Climate Change and Human Activity
Creators: name: Sun, Jiejie
name: Feng, Lei
name: Wang, Tongli (Forest Geneticist)
name: Tian, Xiangni
name: He, Xiao
name: Xia, Hui
name: Wang, Weifeng
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: The impact of climate change and human activities on endangered plants has been a serious concern in forest ecology. Some Carpinus plants have become extinct. Thus, we need to pay more attention to the Carpinus plants that are not yet extinct but are endangered. Here, we employed the species distribution model (SDM) considering different climate change scenarios and human footprint to test the potential habitat changes of three Carpinus species (C. oblongifolia, C. tientaiensis, and C. purpurinervis) in the future. Our results showed that the mean diurnal range of temperature (MDRT), isothermality, mean temperature of wettest quarter, and human footprint were the most influential factors determining the distribution of C. oblongifolia. Precipitation seasonality (coefficient of variation), MDRT, and precipitation of driest quarter were the most important climatic factors affecting C. tientaiensis. The minimum temperature of the coldest month was the most important factor in the distribution of C. purpurinervis. Our results also showed that the three species had different adaptability and habitat change trends under the future climate change scenarios, although they belong to the same genus. The potential habitats of C. oblongifolia would expand in the future, while the potential habitats of C. tientaiensis and C. purpurinervis would decrease for the same period. The predicted changes of these three endangered species on temporal and spatial patterns could provide a theoretical basis for their conservation strategies.
Development of Gold Nanorod NIR Active Surfaces for Human Mesenchymal Stem Cell Detachment
Creators: name: Vegi, Yashaswini
Publisher: name: Swinburne
Year: 2024

description: Enzymatic and non-enzymatic cell detachment solutions in therapeutic industries has many short comings, including being derived from animal/human pancreatic enzymes, cleaving of cell surface proteins leading to disrupted of cell functions and cell death when exposed for longer time period.
Surface-plasmons generated by irradiating surface bound gold nanostructures with near infra-red light can mediate non-toxic cell detachment. In collaboration with St. Vincent's Hospital, Melbourne Australia I have developing a new gold nanorods based coating for 2D substrates and 3D microcarriers, in order to develop biomaterials suitable for stem cell detachment on a clinically relevant scale.
TOP 10 MOST CITED ARTICLES IN OCTOBER 2024 - International Journal of Managing Value and Supply Chains (IJMVSC)
Creators: name: IJMVSC
Publisher: name: Zenodo
Year: 2024

description: International Journal of Managing Value and Supply Chains ( IJMVSC ) is a quarterly open access peer-reviewed journal that publishes articles that contribute new results in all areas of value and supply chain management. The journal provides a platform to disseminate new ideas and new research, advance theories, and propagate best practices in the management of value and supply chain management, looking across both product and service-based businesses. This will include works based in service management, logistics and distribution, operations management, process management, flow control, and customer service. The journal offers a forum in which academics, consultants, and practitioners in a variety of fields can exchange ideas to further research and improve practices in all areas of business. The International Journal of Managing Value and Supply Chains ( IJMVSC ) seek to establish new collaborations, new best practices, and new theories in the management of both product and service-based organizations around the world.
Pitfalls of Fighting with Mucormycosis in an Immunocompromised Patient One Month After Simultaneous Pancreas and Kidney Transplantation (SPK)
Creators: name: Hagerf, Barbora
name: Kudláčková, Michaela
name: Veleba, Jiří
name: Kříž, Jan
name: Saudek, František
name: Girman, Peter
Publisher: name: Zenodo
Year: 2025

description: This work was supported by  National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104)- Funded by the European Union– Next Generation EU).
Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic
Creators: name: Weiss, Matthew J.
name: Hornby, Laura
name: Foroutan, Farid
name: Belga, Sara
name: Bernier, Simon
name: Bhat, Mamatha
name: Buchan, C. Arianne
name: Gagnon, Michael
name: Hardman, Gillian
name: Ibrahim, Maria
name: Luo, Cindy
name: Luong, Me-Linh
name: Mainra, Rahul
name: Manara, Alex R.
name: Sapir-Pichhadze, Ruth
name: Shalhoub, Sarah
name: Shaver, Tina
name: Singh, Jeffrey M.
name: Srinathan, Sujitha
name: Thomas, Ian
name: Wilson, Lindsay C.
name: Wilson, T. Murray
name: Wright, Alissa
name: Mah, Allison
Publisher: name: Wolters Kluwer Health, Inc.
Year: 2021

description: Background. The coronavirus 2019 (COVID-19) pandemic has disrupted health systems worldwide, including solid organ donation and transplantation programs. Guidance on how best to screen patients who are potential organ donors to minimize the risks of COVID-19 as well as how best to manage immunosuppression and reduce the risk of COVID-19 and manage infection in solid organ transplant recipients (SOTr) is needed. Methods. Iterative literature searches were conducted, the last being January 2021, by a team of 3 information specialists. Stakeholders representing key groups undertook the systematic reviews and generation of recommendations using a rapid response approach that respected the Appraisal of Guidelines for Research and Evaluation II and Grading of Recommendations, Assessment, Development and Evaluations frameworks. Results. The systematic reviews addressed multiple questions of interest. In this guidance document, we make 4 strong recommendations, 7 weak recommendations, 3 good practice statements, and 3 statements of “no recommendation.” Conclusions. SOTr and patients on the waitlist are populations of interest in the COVID-19 pandemic. Currently, there is a paucity of high-quality evidence to guide decisions around deceased donation assessments and the management of SOTr and waitlist patients. Inclusion of these populations in clinical trials of therapeutic interventions, including vaccine candidates, is essential to guide best practices.
Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.
Creators: name: Lee, Sunwoo
name: Ochoa, Eguzkine
name: Barwick, Katy
name: Cif, Laura
name: Rodger, Fay
name: Docquier, France
name: Pérez-Dueñas, Belén
name: Clark, Graeme
name: Martin, Ezequiel
name: Banka, Siddharth
name: Kurian, Manju A
name: Maher, Eamonn
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research Article
chromatin disorders
early-onset dystonia
histone lysine methyltransferases (KMTs)
Kabuki syndrome
methylation
neurodevelopmental disorder

description: Funder: Rosetrees Trust
description: Aim & methods: To investigate peripheral blood methylation episignatures in KMT2B-related dystonia (DYT-KMT2B), the authors undertook genome-wide methylation profiling of ∼2 M CpGs using a next-generation sequencing-based assay and compared the findings with those in controls and patients with KMT2D-related Kabuki syndrome type 1 (KS1). Results: A total of 1812 significantly differentially methylated CpG positions (false discovery rate
Institutionelles Open Access – Was funktioniert und was nicht funktioniert
Creators: name: Anderson, Catherine
name: Hess, Philipp
Publisher: name: Zenodo
Year: 2020
Subjects: Institutional Open Access
OA
Gut
Schlecht
S2O
Crowdfunding
Distribution
Preistransparenz
Changing Marketplace

description: Institutionell finanziertes Open Access für Zeitschriften und Bücher findet seit 2012 über verschiedene Player immer mehr Unterstützung. Knowledge Unlatched, Open Library of Humanities, Luminos und TOME sind einige Beispiele für zum Teil sehr unterschiedliche Ansätze. Sie alle haben zum Ziel, Finanzierung für Open Access Monographien in den Geistes- und Sozialwissenschaften zu sichern. Allen Initiativen ist gemein, dass sie durch ein hohes Maß an Experimentieren aktiv die Entwicklung der Modelle vorantreiben. Dass es dabei nicht nur Erfolge, sondern auch wichtige Flops gibt, liegt in der Natur der Sache. Der Vortrag untersucht kritisch, welche Ansätze erfolgreich waren und welche Ideen nicht funktioniert haben und bemüht sich, daraus generalisierende Ableitungen zu treffen. Zielgruppe sind Entscheider in Verlagen und Bibliotheken, die aktiv an der (Weiter-) Entwicklung von Zugangs- und Geschäftsmodellen für OA Zeitschriften und Bücher beteiligt sind.
PO15 Sedação no doente com BAV 2ºgrau: Qual a melhor estratégia para minimização do risco perioperatório?
Creators: name: Branquinho, Juliana
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Volcanic effects on climate: recent advances and future avenues
Creators: name: Marshall, Lauren
name: Maters, Elena
name: Schmidt, Anja
name: Timmreck, Claudia
name: Robock, Alan
name: Toohey, Matthew
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Perspectives
Looking Backwards and Forwards in Volcanology: A Collection of Perspectives on the Trajectory of a Science
Volcanic eruptions
Stratospheric aerosols
Aerosol-climate modelling
Climate

description: Volcanic eruptions have long been studied for their wide range of climatic effects. Although global-scale climatic impacts following the formation of stratospheric sulfate aerosol are well understood, many aspects of the evolution of the early volcanic aerosol cloud and regional impacts are uncertain. In the last twenty years, several advances have been made, mainly due to improved satellite measurements and observations enabling the effects of small-magnitude eruptions to be quantified, new proxy reconstructions used to investigate the impact of past eruptions, and state-of-the-art aerosol-climate modelling that has led to new insights on how volcanic eruptions affect the climate. Looking to the future, knowledge gaps include the role of co-emissions in volcanic plumes, the impact of eruptions on tropical hydroclimate and Northern Hemisphere winter climate, and the role of eruptions in long-term climate change. Future model development, dedicated model intercomparison projects, interdisciplinary collaborations, and the application of advanced statistical techniques will facilitate more complex and detailed studies. Ensuring that the next large-magnitude explosive eruption is well observed will be critical in providing invaluable observations that will bridge remaining gaps in our understanding.
Volcanologists—who are we and where are we going?
Creators: name: Kavanagh, Janine L
name: Annen, Catherine J
name: Burchardt, Steffi
name: Chalk, Caitlin
name: Gallant, Elisabeth
name: Morin, Julie
name: Scarlett, Jazmin
name: Williams, Rebecca
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Perspectives
Looking Backwards and Forwards in Volcanology: A Collection of Perspectives on the Trajectory of a Science
Equality
Diversity
Inclusion
Equity
Justice
Policy
Discrimination
Action

description: Abstract: Equity, diversity and inclusivity (EDI) are principles all scientific groups and organisations should strive to achieve as they secure working conditions, policies and practices that not only promote high-quality scientific output but also well-being in their communities. In this article, we reflect on the progress of EDI in volcanology by presenting data related to memberships of international volcanology organisations, positions on volcanology committees, volcanology awards and lead-authorship on volcanology papers. The sparse demographic data available means our analysis focuses mainly on gender identity discrimination, but we show that discrimination related to ethnicity, sexual orientation, religion, physical ability and socio-economic background is also occurring, with the intersection of these discriminations further exacerbating marginalisation within the volcanology community. We share suggestions and recommendations from other disciplines on how individuals, research groups and organisations can promote, develop and implement new initiatives to call out and tackle discrimination and advance EDI in the volcanological community. There is a lot of potential for improvement if we all see our role in creating a more equitable, diverse and inclusive volcanology community. This requires (1) awareness: acknowledgement of the problem, (2) commitment: through the statement of EDI core values and the development of action plans, codes of conducts and guidelines, (3) action: aiming for representation of all groups, and (4) reflection: development through critical self-reflection and a willingness to address shortcomings.
PO14 Intercostal nerve neurolysis for cancer-associated chest wall pain: a case report.
Creators: name: Duarte, Catarina
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis.
Creators: name: Forster, Samuel C
name: Clare, Simon
name: Beresford-Jones, Benjamin S
name: Harcourt, Katherine
name: Notley, George
name: Stares, Mark D
name: Kumar, Nitin
name: Soderholm, Amelia T
name: Adoum, Anne
name: Wong, Hannah
name: Morón, Bélen
name: Brandt, Cordelia
name: Dougan, Gordon
name: Adams, David J
name: Maloy, Kevin J
name: Pedicord, Virginia
name: Lawley, Trevor D
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Animals
Mice
Bacteroidetes
Colitis
Inflammatory Bowel Diseases
Disease Models, Animal
Gastrointestinal Microbiome

description: Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous gut bacteria drive immunophenotypic variability in mouse models of human disease remains poorly understood. We performed a large-scale experiment using 579 genetically identical laboratory mice from a single animal facility, designed to identify the causes of disease variability in the widely used dextran sulphate sodium mouse model of inflammatory bowel disease. Commonly used treatment endpoint measures-weight loss and intestinal pathology-showed limited correlation and varied across mouse lineages. Analysis of the gut microbiome, coupled with machine learning and targeted anaerobic culturing, identified and isolated two previously undescribed species, Duncaniella muricolitica and Alistipes okayasuensis, and demonstrated that they exert dominant effects in the dextran sulphate sodium model leading to variable treatment endpoint measures. We show that the identified gut microbial species are common, but not ubiquitous, in mouse facilities around the world, and suggest that researchers monitor for these species to provide experimental design opportunities for improved mouse models of human intestinal diseases.
PO13 Chemical neurolysis for the conservative treatment of hip fractures: a case series.
Creators: name: Duarte1, Catarina
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Auto-generated database of semiconductor band gaps using ChemDataExtractor.
Creators: name: Dong, Qingyang
name: Cole, Jacqui
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Data Descriptor
/639/766/1130/2798
/639/766/119/1000
/639/301/1005/1007
/639/301/119/1000
data-descriptor

description: Large-scale databases of band gap information about semiconductors that are curated from the scientific literature have significant usefulness for computational databases and general semiconductor materials research. This work presents an auto-generated database of 100,236 semiconductor band gap records, extracted from 128,776 journal articles with their associated temperature information. The database was produced using ChemDataExtractor version 2.0, a 'chemistry-aware' software toolkit that uses Natural Language Processing (NLP) and machine-learning methods to extract chemical data from scientific documents. The modified Snowball algorithm of ChemDataExtractor has been extended to incorporate nested models, optimized by hyperparameter analysis, and used together with the default NLP parsers to achieve optimal quality of the database. Evaluation of the database shows a weighted precision of 84% and a weighted recall of 65%. To the best of our knowledge, this is the largest open-source non-computational band gap database to date. Database records are available in CSV, JSON, and MongoDB formats, which are machine readable and can assist data mining and semiconductor materials discovery.
PO12 Videolaryngoscopic awake intubation in the sitting position: A case report
Creators: name: Duarte1, Catarina
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
แบบแผนของเรือนพื้นถิ่นไทลื้อ: ทิศทาง การจัดวางพื้นที่ และลําดับศักดิ์ของพื้นที่ หมู่บ้านหุม เมืองมาง สิบสองปันนา ประเทศจีน
Creators: name: ธนิก หมื่นคําวัง
Publisher: name: Thammasat University
Year: 2020
Subjects: แบบแผน
เรือนพื้นถิ่นไทลื้อ
ทิศทาง
การจัดวางพื้นที่
ลําดับศักดิ์ของพื้นที่
สิบสองปันนา

description: Journal of Architectural/Planning Research and Studies, 17, 2, 59-78
A database of refractive indices and dielectric constants auto-generated using ChemDataExtractor.
Creators: name: Zhao, Jiuyang
name: Cole, Jacqui
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Data Descriptor
/639/624/400
/639/766/400
/639/301/1019/1015
/639/301/1019/385
data-descriptor

description: The ability to auto-generate databases of optical properties holds great potential for advancing optical research, especially with regards to the data-driven discovery of optical materials. An optical property database of refractive indices and dielectric constants is presented, which comprises a total of 49,076 refractive index and 60,804 dielectric constant data records on 11,054 unique chemicals. The database was auto-generated using the state-of-the-art natural language processing software, ChemDataExtractor, using a corpus of 388,461 scientific papers. The data repository offers a representative overview of the information on linear optical properties that resides in scientific papers from the past 30 years. Public availability of these data will enable a quick search for the optical property of certain materials. The large size of this repository will accelerate data-driven research on the design and prediction of optical materials and their properties. To the best of our knowledge, this is the first auto-generated database of optical properties from a large number of scientific papers. We provide a web interface to aid the use of our database.
Secure deep neural networks in adversarial settings
Creators: name: Wang, Derui (Derek)
Publisher: name: Swinburne
Year: 2024

description: Artificial intelligence (AI) has been introduced in almost every aspect of our lives to assist in smart decision making. As a key technology, it is fundamentally changing the way people work and live. The thesis studies the security problems of AI models. The research exposes the attack surface of modern AI applications and proposes defences to mitigate the threats. It is a critical step in building trustworthy and resilient AI applications that can truly benefit the nation.
Alternative splicing modulation by G-quadruplexes.
Creators: name: Georgakopoulos-Soares, Ilias
name: Parada, Guillermo E
name: Wong, Hei Yuen
name: Medhi, Ragini
name: Furlan, Giulia
name: Munita, Roberto
name: Miska, Eric A
name: Kwok, Chun Kit
name: Hemberg, Martin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/208/212/2019
/631/337/2019
/42/44
/45/77
/45/29
article

description: Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched ~3-fold near splice junctions. The importance of G4s in RNA is emphasised by a higher enrichment for the non-template strand. RNA-seq data from mouse and human neurons reveals an enrichment of G4s at exons that were skipped following depolarisation induced by potassium chloride. We validate the formation of stable RNA G4s for three candidate splice sites by circular dichroism spectroscopy, UV-melting and fluorescence measurements. Moreover, we find that sQTLs are enriched at G4s, and a minigene experiment provides further support for their role in promoting exon inclusion. Analysis of >1,800 high-throughput experiments reveals multiple RNA binding proteins associated with G4s. Finally, exploration of G4 motifs across eleven species shows strong enrichment at splice sites in mammals and birds, suggesting an evolutionary conserved splice regulatory mechanism.
แนวทางปรับปรุงกรอบด้านหน้าอาคารย่านเมืองเก่า เพื่อพัฒนาการท่องเที่ยวเมืองหนองคาย
Creators: name: ปกรณ์ พัฒนานุโรจน์
Publisher: name: Thammasat University
Year: 2020
Subjects: กรอบด้านหน้าอาคาร
ลักษณะเฉพาะ
อาคารรูปแบบอาณานิคม
ย่านเมืองเก่าหนองคาย
การอนุรักษ์อาคาร

description: Journal of Architectural/Planning Research and Studies, 17, 2, 141-162
PO11 Siderose Medular Superficial: valerá a pena correr riscos?
Creators: name: Santos, João Carlos
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients.
Creators: name: Cantoni, Diego
name: Mayora-Neto, Martin
name: Thakur, Nazia
name: Elrefaey, Ahmed ME
name: Newman, Joseph
name: Vishwanath, Sneha
name: Nadesalingam, Angalee
name: Chan, Andrew
name: Smith, Peter
name: Castillo-Olivares, Javier
name: Baxendale, Helen
name: Charleston, Bryan
name: Heeney, Jonathan
name: Bailey, Dalan
name: Temperton, Nigel
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/326/596
/631/326/590
/13/106
/13/1
/13/109
article

description: RaTG13 is a close relative of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, sharing 96% sequence similarity at the genome-wide level. The spike receptor binding domain (RBD) of RaTG13 contains a number of amino acid substitutions when compared to SARS-CoV-2, likely impacting affinity for the ACE2 receptor. Antigenic differences between the viruses are less well understood, especially whether RaTG13 spike can be efficiently neutralised by antibodies generated from infection with, or vaccination against, SARS-CoV-2. Using RaTG13 and SARS-CoV-2 pseudotypes we compared neutralisation using convalescent sera from previously infected patients or vaccinated healthcare workers. Surprisingly, our results revealed that RaTG13 was more efficiently neutralised than SARS-CoV-2. In addition, neutralisation assays using spike mutants harbouring single and combinatorial amino acid substitutions within the RBD demonstrated that both spike proteins can tolerate multiple changes without dramatically reducing neutralisation. Moreover, introducing the 484 K mutation into RaTG13 resulted in increased neutralisation, in contrast to the same mutation in SARS-CoV-2 (E484K). This is despite E484K having a well-documented role in immune evasion in variants of concern (VOC) such as B.1.351 (Beta). These results indicate that the future spill-over of RaTG13 and/or related sarbecoviruses could be mitigated using current SARS-CoV-2-based vaccination strategies.
Collective Memory, an Effective Tool for Adaptive Reuse in Modern Heritage: Challenges and Opportunities Identified in the Case of Gropius Torten Estate, Dessau
Creators: name: Ahmed, Sayed
Publisher: name: Thammasat University
Year: 2020
Subjects: Bauhaus
Modernism
Social-Functionalist Housing
World Heritage Site
Collective Memory

description: Journal of Architectural/Planning Research and Studies, 17, 2, 163-180
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.
Creators: name: Zhang, Yang
name: Garcia-Ibanez, Laura
name: Ulbricht, Carolin
name: Lok, Laurence SC
name: Pike, Jeremy A
name: Mueller-Winkler, Jennifer
name: Dennison, Thomas W
name: Ferdinand, John R
name: Burnett, Cameron JM
name: Yam-Puc, Juan C
name: Zhang, Lingling
name: Alfaro, Raul Maqueda
name: Takahama, Yousuke
name: Ohigashi, Izumi
name: Brown, Geoffrey
name: Kurosaki, Tomohiro
name: Tybulewicz, Victor LJ
name: Rot, Antal
name: Hauser, Anja E
name: Clatworthy, Menna R
name: Toellner, Kai-Michael
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/250/2152/2153/1982
/631/250/2152/2153/1571
/631/250/1620/1616
/631/250/2503
/13/31
/13/21
/13/1
/13/51
/14/35
/14/63
/14/69
/38/47
/38/77
/38/88
/64/60
article

description: Infection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory pathways of B cells emerging from germinal centers (BEM) and find that many BEM cells migrate into the lymph node subcapsular sinus (SCS) guided by sphingosine-1-phosphate (S1P). From the SCS, BEM cells may exit the lymph node to enter distant tissues, while some BEM cells interact with and take up antigen from SCS macrophages, followed by CCL21-guided return towards the GC. Disruption of local CCL21 gradients inhibits the recycling of BEM cells and results in less efficient adaption to antigenic variation. Our findings thus suggest that the recycling of antigen variant-specific BEM cells and transport of antigen back to GC may support affinity maturation to antigenic drift.
Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP
Creators: name: Melo, Eduardo Pinho
name: Konno, Tasuku
name: Farace, Ilaria
name: Awadelkareem, Mosab Ali
name: Skov, Lise R
name: Teodoro, Fernando
name: Sancho, Teresa P
name: Paton, Adrienne W
name: Paton, James C
name: Fares, Matthew
name: Paulo, Pedro MR
name: Zhang, Xin
name: Avezov, Edward
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/80/304
/631/80/470/1981
/631/80/470/1463
/631/80/470/2284
/9
/13
/13/31
/13/100
/13/106
/13/109
/14
/14/19
/14/34
/14/63
/38/88
/82/16
article

description: Funder: This study received Portuguese national funds from FCT - Foundation for Science and Technology through project UIDB/04326/2020, UIDP/04326/2020 and LA/P70101/2020, and from the operational programmes CRESC Algarve 2020 and COMPETE 2020 through project EMBRC.PT ALG-01-0145-FEDER-022121
description: Funder: UK Medical Research Council
description: Abstract: Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation prone species. Protein aggregation underlies pathologies including neurodegeneration. Aggregates’ formation is antagonised by molecular chaperones, with cytoplasmic machinery resolving insoluble protein aggregates. However, it is unknown whether an analogous disaggregation system exists in the Endoplasmic Reticulum (ER) where ~30% of the proteome is synthesised. Here we show that the ER of a variety of mammalian cell types, including neurons, is endowed with the capability to resolve protein aggregates under stress. Utilising a purpose-developed protein aggregation probing system with a sub-organellar resolution, we observe steady-state aggregate accumulation in the ER. Pharmacological induction of ER stress does not augment aggregates, but rather stimulate their clearance within hours. We show that this dissagregation activity is catalysed by the stress-responsive ER molecular chaperone – BiP. This work reveals a hitherto unknow, non-redundant strand of the proteostasis-restorative ER stress response.
Clinicians’ perceptions of a potential wearable device for capturing upper limb activity post-stroke: a qualitative focus group study
Creators: name: Simpson, Lisa Ann
name: Menon, Carlo
name: Hodgson, Antony J.
name: Mortenson, W. Ben
name: Eng, Janice
Publisher: name: BioMed Central
Year: 2021

description: Background There is growing interest in the use of wearable devices that track upper limb activity after stroke to help determine and motivate the optimal dose of upper limb practice. The purpose of this study was to explore clinicians’ perceptions of a prospective wearable device that captures upper limb activity to assist in the design of devices for use in rehabilitation practice. Methods Four focus groups with 18 clinicians (occupational and physical therapists with stroke practice experience from a hospital or private practice setting) were conducted. Data were analyzed thematically. Results Our analysis revealed three themes: (1) “Quantity and quality is ideal” emphasized how an ideal device would capture both quantity and quality of movement; (2) “Most useful outside therapy sessions” described how therapists foresaw using the device outside of therapy sessions to monitor homework adherence, provide self-monitoring of use, motivate greater use and provide biofeedback on movement quality; (3) “User-friendly please” advocated for the creation of a device that was easy to use and customizable, which reflected the client-centered nature of their treatment. Conclusions Findings from this study suggest that clinicians support the development of wearable devices that capture upper limb activity outside of therapy for individuals with some reach to grasp ability. Devices that are easy to use and capture both quality and quantity may result in greater uptake in the clinical setting. Future studies examining acceptability of wearable devices for tracking upper limb activity from the perspective of individuals with stroke are needed.
title: Automated Cephalometric Landmark Localization using a Coupled Shape Model
Creators: name: Wirtz, Andreas
name: Lam, Julian
name: Wesarg, Stefan
Publisher: name: De Gruyter
Year: 2025

description: Cephalometric analysis is an important method in orthodontics for the diagnosis and treatment of patients. It is performed manually in clinical practice, therefore automation of this time consuming task would be of great assistance. In order to provide dentists with such tools, a robust and accurate identification of the necessary landmarks is required. However, poor image quality of lateral cephalograms like low contrast or noise make this task difficult. In this paper, an approach for automatic landmark localization is presented and used to find 19 landmarks in lateral cephalometric images. An initial predicting of the individual landmark locations is done by using a 2-D coupled shape model to utilize the spatial relation between landmarks and other anatomical structures. These predictions are refined with a Hough Forest to determine the final landmark location. The approach achieves competitive performance with a successful detection rate of 70.24% on 250 images for the clinically relevant 2mm accuracy range.
PO10 PROGRAMA DE FORMAÇÃO EM ANESTESIOLOGIA NA VIA CLÁSSICA DA ESPECIALIDADE DE MEDICINA INTENSIVA
Creators: name: Cravo, Hugo
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
PO08 Differential Target Multiplexed Programming for the Treatment of Complex Regional Pain Syndrome
Creators: name: Dornelles1, Larissa
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
title: Die Logik des Ausbruchs
title: Formierung von Covid-19 durch Krisenbearbeitungsweisen
titleType: Subtitle
Creators: name: Füller, Henning
name: Dzudzek, Iris
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 550 Earth sciences

description: Die unzähligen und weitreichenden Bezüge der gesellschaftlichen Auseinandersetzung mit der Covid-19-Infektion stehen nun schon einige Zeit im Zentrum sozialwissenschaftlicher Aufmerksamkeit. Ergänzend zu prägnanten unmittelbaren Diagnosen der Effekte und Blindstellen bei der Bewältigung richten wir das Augenmerk auf strukturelle Einstellungen im Vorfeld der Pandemie. Die aktuelle Krise entfaltet sich teils in der Realisierung solcher Voreinstellungen. Mit der kritischen Sozialepidemiologie führen wir eine Perspektive ein, die darauf verweist, dass Gesundheit eine soziale Frage ist. Mit Hilfe der Perspektive des worldings verfolgen wir, wie bestimmte Logiken und Regierungsweisen der Krise sich im Moment der Krise materiell entfalten, dabei an Kontexte angepasst werden, sich verändern und dabei ganz konkrete Welten der Krisenbewältigung erschaffen. Unter der Klammer „Logik des Ausbruchs“ zeigen wir die Verschränkung von zwei Momenten – die Klassifikation als Feind sowie die Zurichtung als Sicherheitsproblem – die richtungsweisend für die gesellschaftliche Interaktion mit dem neuartigen Virus sind. In dem wir die aktuelle Bearbeitungsweise der Krise als eine strukturell voreingestellte, machtgeladene, aber letzten Endes nur eine von vielen anderen möglichen dekonstruieren, öffnen wir den Blick für Bedingungen einer solidarischen Politik des Lebens, die wir abschließend knapp skizzieren. Damit liefert der Artikel einen Beitrag zu einer Geographie der Gesundheit, die im Sinne einer Sozialepidemiologie zweiter Ordnung nicht nach der Verbreitung und Bekämpfung von Viren und Seuchen fragt, sondern nach den Topologien der Macht, die den Ausbruch strukturieren.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Bariatric surgery prior to posterior lumbar interbody fusion is associated with higher revision rate but lower medical complication rate compared with morbidly obese patients
Creators: name: Arakawa, Jordan
name: Lin, Clifford
name: Wright, James
name: Ryu, W.H. Andrew
name: Yoo, Jung
Publisher: name: Oregon Health and Science University
Year: 2024
Subjects: subject: Obesity
subject: Bariatrics
subject: Bariatric Surgery
subject: Pseudarthrosis
subject: Body Mass Index
subject: PLIF
subject: spine fusion
subject: revision rate
subject: BMI

description: There is a paucity of data on bariatric surgery (BS) prior to spine surgery. Some literature suggests that bariatric surgery (BS) prior to spine surgery may be cost-effective and lower rates of medical complications when compared to morbidly obese (MO) patients, however, the studies have a small number of patients and statistically significant differences have not been reported.
PO07 Reação anafilática repetida, após administração de indometacina retal
Creators: name: Santos, João
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
PO06 POPPING THE BUBBLE: AN ANESTHETIC SURPRISE!
Creators: name: Salvador, Pedro Vaz
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Impact of business analytics on large organisations: an information processing theory perspective
Creators: name: Shamekhi, Maryamalsadat
Publisher: name: Swinburne
Year: 2024

description: This study aims at answering this question: how does the use of business analytics impact organisations? The findings may guide organisations that are eager to adopt and use business analytics to identify the factors that will be affected by using business analytics and provide an overview of expectations, benefits, and challenges of using business analytics. In addition, this study extended and enriched Information Processing Theory by including categories directly related to business analytics use. To validate the proposed framework, this study examines the perspectives of both technical and business users of business analytics in four large organisations from different industry sectors.
PO05 DESAFIOS PERIOPERATÓRIOS DO DOENTE COM PARAGANGLIOMA – UM CASO CLÍNICO
Creators: name: Miguel, Bernardo
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
PO04 PERIOPERATIVE CARE IN CHILDREN WITH MEDIUM-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY - A CASE REPORT
Creators: name: Graça1, Maria Inês
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
PO03 Cetoacidose euglicémica, uma complicação atual no peri-operatório
Creators: name: Madruga, Carolina
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
HalluciNet-ing Spatiotemporal Representations Using a 2D-CNN
Creators: name: Parmar, Paritosh
name: Morris, Brendan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Spatiotemporal representations learned using 3D convolutional neural networks (CNN) are currently used in state-of-the-art approaches for action-related tasks. However, 3D-CNN are notorious for being memory and compute resource intensive as compared with more simple 2D-CNN architectures. We propose to hallucinate spatiotemporal representations from a 3D-CNN teacher with a 2D-CNN student. By requiring the 2D-CNN to predict the future and intuit upcoming activity, it is encouraged to gain a deeper understanding of actions and how they evolve. The hallucination task is treated as an auxiliary task, which can be used with any other action-related task in a multitask learning setting. Thorough experimental evaluation, it is shown that the hallucination task indeed helps improve performance on action recognition, action quality assessment, and dynamic scene recognition tasks. From a practical standpoint, being able to hallucinate spatiotemporal representations without an actual 3D-CNN can enable deployment in resource-constrained scenarios, such as with limited computing power and/or lower bandwidth. We also observed that our hallucination task has utility not only during the training phase, but also during the pre-training phase.
PO02 CAPSAICINA TÓPICA 8% NA FACE – DOIS CASOS CLÍNICOS
Creators: name: Camile Lanzaro; Nádia Andrade; Zélia Martins; Isabel Preza; Maria João Costa
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
PO01 A DELAYED CATASTROPHE: A CASE REPORT ON SHOCK AND EMERGENCY HYSTERECTOMY
Creators: name: Graça, Maria Inês
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO08 BNP PARAVERTEBRAL PARA CIRURGIA DA MAMA EM GRÁVIDA DO 1º TRIMESTRE
Creators: name: Xavier1, Beatriz
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO07 PROPOFOL FOR INDUCTION AND MAINTENANCE OF ANESTHESIA IN PATIENTS WITH BRUGADA SYNDROME
Creators: name: Tiago, Catarina
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO06 FORMAÇÃO EM SUPORTE BÁSICO DE VIDA NO 1º CICLO: DE PEQUENINO É QUE SE TORCE O PEPINO!
Creators: name: Nascimento, Maria João
name: Nascimento, Maria João
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO05 PRE-OPERATIVE FLUID THERAPY AND THIRST IN ELECTIVE GENERAL SURGERY: A CROSS-SECTIONAL STUDY
Creators: name: Adams, Mariana
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO04 NEUROMODULAÇÃO DO GÂNGLIO DA RAIZ DORSAL NO SÍNDROME DOLOROSO REGIONAL COMPLEXO – UM DESAFIO TÉCNICO
Creators: name: Galacho1, João Bonito
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO03 Epidural catheter in liver resection surgery: friend or foe? A retrospective study
Creators: name: Marques, Beatriz
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: x
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Resumos submetidos ao Congresso da SPA 2024
Creators: name: Reis, Pedro
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: c
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO02 MANAGEMENT OF PERIPHERAL NEUROPATHY AFTER DELIVERY: ROLE AND LEADERSHIP OF THE ANESTHESIOLOGIST
Creators: name: Guimarães, Joana
name: P. Pedrosa, Filipa
name: Santos-Jorge, Inês
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: Category: Obstetric Anesthesia


Background: Postpartum nerve damage is an unusual complication of vaginal delivery mostly secondary to stretch or compression of the affected nerve due to delivery positioning. It is often underreported. We report a case of unilateral deep peroneal neuropathy in a patient under labor analgesia with epidural technique. Differential diagnosis with neuraxial complications is essential.  Anesthesiologists play a pivotal role on the evaluation, diagnosis and management of these patients.


Case Description: A nulliparous 22-year-old woman complained of weakness and numbness of the right inferior limb impairing gait, two days after vaginal delivery. Epidural technique was performed on first attempt and paresthesia were not reported. She was under labor epidural analgesia for 36 hours, with a programmed intermittent epidural bolus protocol using ropivacaine 0,1% with sufentanil 0,2 mcg/ml. She reported paresthesia in the right inferior limb and pain on the contralateral side during labor analgesia. Anesthesiologist evaluation described unilateral right-sided block and epidural catheter was withdrawn two centimeters, achieving a good pain control. Postpartum neurologic examination revealed a sensory loss of lateral leg and dorsum of the foot and weakness on dorsiflexion of the foot. Lumbar magnetic resonance imaging ruled out neurologic complications related to the epidural technique. Right deep peroneal neuropathy was inferred. Prolonged and/or excessive pressure over the fibular head during delivery positioning was formulated as etiology. The patient was referred to physiatry to start early rehabilitation program to improve function.


Conclusion: Understanding the risk factors and preventive measures, such as frequent repositioning and avoidance of excessive compression during delivery, for postpartum neuropathy are essential. Early recognition of neurological symptoms on the postpartum period is vital for an adequate and timely intervention. Excluding neuraxial complications is the first approach on these patients and therefore, anesthesiologists lead their early management. Anesthesiologists have a mainstay role on educating and engaging teams to adopt preventive measures and to create tools for early identification and referral of these patients. Multidisciplinary work with obstetrics, neurology and physiatry is essential to improve outcomes of postpartum neuropathy.
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
CO01 Adesão à Terapêutica Farmacológica após a Primeira Consulta de Dor Crónica: Ainda é um Desafio?
Creators: name: Camile Lanzaro; Daniela Cristelo; Ana Silva; Gisela Vasconcelos
Publisher: name: Revista da Sociedade Portuguesa de Anestesiologia
Year: 2024

description: .
description: Revista da Sociedade Portuguesa de Anestesiologia, Vol. 33 No. 1 (2024): Vol. 33 N.º 1 (2024): SUPLEMENTO Revista da Sociedade Portuguesa de Anestesiologia
Improvement of compacted soil-cement using natural rubber latex for pavement applications
Creators: name: Buritatum, Apinun
Publisher: name: Swinburne
Year: 2024

description: This thesis studies the possibility of using natural rubber latex (NRL) to improve the engineering properties of compacted soil-cement in pavement applications. NRL replacement was found to significantly enhance the mechanical strengths of cement-NRL stabilized soil. The optimum NRL replacement ratios providing the highest mechanical strengths, durability, and fatigue life were found at 20%, 15%, and 10% for 3%, 5%, and 7% cement contents, respectively. Even though the NRL films within the soil-cement matrix improved the cohesion of the soil matrix, it was found to retard cementation bonding. As such, the excessive NRL replacement not only reduced the compatibility but also retarded the cement hydration and, hence, the strength reduction. The outcome of this research will result in the promotion of NRL utilization as an eco-friendly and sustainable additive in cement stabilized pavement base/subbase courses.
Memo from M. V. W. to Edward R. Hoehl, April 29, 1951
Creators: name: M. V., W.
Publisher: name: Unknown
Year: 1951
Subjects: Stony Brook
Concert halls
Concerts
Correspondence

description: This memo is written by M. V. W. to Edward R. Hoehl on April 29, 1951, in regards to scheduled events at Dogwood Hollow with rain days in place.