cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characteristics of music intervention for anxiety relief in patients undergoing cardiac catheterization: Scoping Review Protocol
Creators: name: de Carvalho Batista, Letícia
name: Melo, Michele
name: de Almeida Lopes Monteiro da Cruz, Diná
name: de Cassia Gengo e Silva Butcher, Rita
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: Introduction: Although music is a non-pharmacological intervention that has been used to reduce anxiety and its manifestations in patients undergoing cardiac catheterization, its effectiveness is controversial. The lack of knowledge of the characteristics that constitute such an intervention may contribute to the lack of consistency. To map the characteristics music intervention to reduce anxiety in patients undergoing cardiac catheterization. Methods and analysis: A scoping review will be conducted according to the Joanna Briggs Institute (JBI) methodology. The searches will be performed using PubMed, CINAHL, PsycINFO, Cochrane, EMBASE, Scopus and LILACS databases. Unpublished studies will be searched using the CAPES Thesis Portal, DART-Europe E-theses Portal, Theses Canada Portal, Pro-Quest and Google Scholar databases. This review will include experimental and quasi-experimental studies that used intervention with music to reduce anxiety in adult patients before, during, or after cardiac catheterization in the hospital setting, published in Portuguese, English, and Spanish with no limit on the year of publication. Two independent reviewers will perform the selection of documents for full reading and data extraction. A third reviewer will resolve disagreements. The data extracted will include the characteristics of the manuscripts, of the research report, and of the intervention. There will be no critical appraisal of the studies. The results will be presented with a data map and in a descriptive approach, aligned with the objective of the scoping review. Ethics and dissemination: This protocol will be published in the registry on the OSF registration website.
title: Leigh syndrome: is there a correlation between diffusion abnormalities and clinical presentation?
Creators: name: Kakkar, Chandan
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: MR
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Metabolic disorders
subject: Congenital

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Leigh syndrome is a progressive neurodegenerative disorder of infancy/early childhood secondary to mitochondrial dysfunction. Typical MRI findings include basal ganglia and brainstem changes secondary to spongiform...
Vibrio fischeri -derived outer membrane vesicles trigger host development: OMV deliver signals in the squid/vibrio symbiosis
Creators: name: Mcfall-Ngai, Margaret
name: Ruby, Edward
name: Goldman, William
name: Aschtgen, Marie-Stephanie
name: Wetzel, Keith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Outer membrane vesicles (OMV) are critical elements in many host-cell/microbe interactions. Previous studies of the symbiotic association between Euprymna scolopes and Vibrio fischeri had shown that, within 12 h of colonizing crypts deep within the squid’s light organ, the symbionts trigger an irreversible program of tissue development in the host. Here, we report that OMV produced by V. fischeri are powerful contributors to this process. The first detectable host response to the OMV is an increased trafficking of macrophage-like cells called hemocytes into surface epithelial tissues. We showed that exposing the squid to other Vibrio species fails to induce this trafficking; however, addition of a high concentration of their OMV, which can diffuse into the crypts, does. We also provide evidence that tracheal cytotoxin (TCT) release by the symbionts, which can induce hemocyte trafficking, is not part of the OMV cargo, suggesting two distinct mechanisms to induce the same morphogenesis event. By manipulating the timing and localization of OMV signal delivery, we showed that hemocyte trafficking is fully induced only when V. fischeri, the sole species able to reach and grow in the crypts, succeeds in establishing a sustained colonization. Further, our data suggest that the host detection of OMV serves as a symbiotic checkpoint prior to inducing irreversible morphogenesis.
title: The BI-RADS 5th edition density scale and breast cancer risk: a case-control study
Creators: name: Abdolell, Mohamed
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Mammography
subject: Statistics
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Mammographic breast density is an independent risk factor for breast cancer and is also associated with numerous known breast cancer risk factors such as reproductive history and hormone replacement therapy.[1-4] Numerous studies have shown that...
title: Endovascular treatment of brain aneurysms: results of a 15 years single-center experience
Creators: name: Sacchetti, Federico
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional vascular
subject: Neuroradiology brain
subject: Vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: MR-Angiography
subject: Embolisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: This is a retrospective analysis of a 15-year single-centre experience in endovascular treatment of brain aneurysms. 460 patients underwent endovascular treatment; 527 aneurysms were treated, 212 ruptured and 315 unruptured. Morphological...
Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy
Creators: name: Xu, Liang
name: Wu, Xiaoqing
name: Slone, Samuel
name: Tranter, Michael
name: Aube, Jeffrey
name: Anthony, Sarah R.
name: Benoit, Joshua B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The RNA binding protein Human antigen R (HuR) interacts with specific AU-rich domains in target mRNAs and is highly expressed in many cell types, including cardiomyocytes. However, the role of HuR in cardiac physiology is largely unknown. Our results show that HuR undergoes cytoplasmic translocation, indicative of its activation, in hypertrophic cardiac myocytes. Specifically, HuR cytoplasmic translocation is significantly increased in NRVMs (neonatal rat ventricular myocytes) following treatment with phenylephrine or angiotensin II, agonists of two independent Gαq-coupled GPCRs known to induce hypertrophy. This Gq-mediated HuR activation is dependent on p38 MAP kinase, but not canonical Gq-PKC signaling. Furthermore, we show that HuR activation is necessary for Gq-mediated hypertrophic growth of NRVMs as siRNA-mediated knockdown of HuR inhibits hypertrophy as measured by cell size and expression of ANF (atrial natriuretic factor). Additionally, HuR overexpression is sufficient to induce hypertrophic cell growth. To decipher the downstream mechanisms by which HuR translocation promotes cardiomyocyte hypertrophy, we assessed the role of HuR in the transcriptional activity of NFAT (nuclear factor of activated T cells), the activation of which is a hallmark of cardiac hypertrophy. Using an NFAT-luciferase reporter assay, we show an acute inhibition of NFAT transcriptional activity following pharmacological inhibition of HuR. In conclusion, our results identify HuR as a novel mediator of cardiac hypertrophy downstream of the Gq-p38 MAPK pathway, and suggest modulation of NFAT activity as a potential mechanism.
title: Prognostic value of CT-angiographic pulmonary artery obstruction indices in patients with acute pulmonary embolism
Creators: name: Wiśniewska, Małgorzata
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Thorax
subject: CT-Angiography
subject: Diagnostic procedure
subject: Embolism / Thrombosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To assess a prognostic value of pulmonary artery obstruction indices (PAOIs) in predicting a complicated clinical course of acute pulmonary embolism...
Does bigram legality constrain the transposed-letter effect?
Creators: name: Schmalz, Xenia
Publisher: name: Open Science Framework
Year: 2022

description: Here, we aim to provide a conceptual replication of a finding by Perea & Carreiras (2008, Language and Cognitive Processes): in their Experiment 1, they report that, using a masked priming paradigm, transposed-letter primes (e.g., jugde - JUDGE) provide stronger facilitation of target word recognition, when the transposed letter pair forms an illegal bigram.
The Brain Basis of Positive and Negative Affect: Evidence from a Meta-Analysis of the Human Neuroimaging Literature
Creators: name: Weber, Jochen
name: Wager, Tor D.
name: Lindquist, Kristen A.
name: Barrett, Lisa Feldman
name: Satpute, Ajay B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The ability to experience pleasant or unpleasant feelings or to represent objects as “positive” or “negative” is known as representing hedonic “valence.” Although scientists overwhelmingly agree that valence is a basic psychological phenomenon, debate continues about how to best conceptualize it scientifically. We used a meta-analysis of 397 functional magnetic resonance imaging (fMRI) and positron emission tomography studies (containing 914 experimental contrasts and 6827 participants) to test 3 competing hypotheses about the brain basis of valence: the bipolarity hypothesis that positive and negative affect are supported by a brain system that monotonically increases and/or decreases along the valence dimension, the bivalent hypothesis that positive and negative affect are supported by independent brain systems, and the affective workspace hypothesis that positive and negative affect are supported by a flexible set of valence-general regions. We found little evidence for the bipolar or bivalent hypotheses. Findings instead supported the hypothesis that, at the level of brain activity measurable by fMRI, valence is flexibly implemented across instances by a set of valence-general limbic and paralimbic brain regions.
Pre-pregnancy and pregnancy cohorts - a scoping review protocol
Creators: name: Maxwell, Lauren
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: The following is a protocol for a scoping review, which will focus on the measurement of different exposures of interest in pregnancy and prepregnancy cohorts to better understand what can be ascertained from existing cohorts regarding the short- and long-term effects of different types of exposures during pregnancy on immediate pregnancy outcomes and later life developmental outcomes.
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
Creators: name: Holbrook, Joanna D.
name: Buss, Claudia
name: Meaney, Michael J.
name: Fortier, Marielle V.
name: Entringer, Sonja
name: Kwek, Kenneth
name: Shen, Mojun
name: Saw, Seang-Mei
name: Heim, Christine M.
name: O'donnell, Kieran J.
name: Qiu, Anqi
name: Karnani, Neerja
name: Gluckman, Peter D.
name: Wadhwa, Pathik D.
name: Styner, Martin
name: Chong, Yap-Seng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.
Detection of Enhancement in Number Densities of Background Galaxies due to Magnification by Massive Galaxy Clusters
Creators: name: Chiu, I.
name: Dietrich, J. P.
name: Mohr, J.
name: Applegate, D. E.
name: Benson, B. A.
name: Bleem, L. E.
name: Bayliss, M. B.
name: Bocquet, S.
name: Carlstrom, J. E.
name: Capasso, R.
name: Desai, S.
name: Gangkofner, C.
name: Gonzalez, A. H.
name: Gupta, N.
name: Hennig, C.
name: Hoekstra, H.
name: von der Linden, A.
name: Liu, J.
name: McDonald, M.
name: Reichardt, C. L.
name: Saro, A.
name: Schrabback, T.
name: Strazzullo, V.
name: Stubbs, C. W.
name: Zenteno, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a detection of the enhancement in the number densities of background galaxies induced from lensing magnification and use it to test the Sunyaev-Zel'dovich effect (SZE) inferred masses in a sample of 19 galaxy clusters with median redshift $z\simeq0.42$ selected from the South Pole Telescope SPT-SZ survey. Two background galaxy populations are selected for this study through their photometric colours; they have median redshifts ${z}_{\mathrm{median}}\simeq0.9$ (low-$z$ background) and ${z}_{\mathrm{median}}\simeq1.8$ (high-$z$ background). Stacking these populations, we detect the magnification bias effect at $3.3σ$ and $1.3σ$ for the low- and high-$z$ backgrounds, respectively. We fit NFW models simultaneously to all observed magnification bias profiles to estimate the multiplicative factor $η$ that describes the ratio of the weak lensing mass to the mass inferred from the SZE observable-mass relation. We further quantify systematic uncertainties in $η$ resulting from the photometric noise and bias, the cluster galaxy contamination and the estimations of the background properties. The resulting $η$ for the combined background populations with $1σ$ uncertainties is $0.83\pm0.24\mathrm{(stat)}\pm0.074\mathrm{(sys)}$, indicating good consistency between the lensing and the SZE-inferred masses. We use our best-fit $η$ to predict the weak lensing shear profiles and compare these predictions with observations, showing agreement between the magnification and shear mass constraints. This work demonstrates the promise of using the magnification as a complementary method to estimate cluster masses in large surveys.
description: 16 pages, 10 figures, accepted for publication in MNRAS
title: Accuracy in antenatal ultrasound in diagnosis of posterior fossa lesions with postnatal MRI correlation
Creators: name: SHAH, DIGISH
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Foetal imaging
subject: Ultrasound
subject: MR
subject: Intrauterine diagnosis
subject: Congenital

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To evaluate the accuracy of antenatal imaging in differentiating posterior fossa lesions and to follow up with postnatal outcome of the affected...
GIMME
Creators: name: Hardi, Felicia
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Developmental Neuroscience
subject: Developmental Psychology
subject: Life Sciences
subject: Neuroscience and Neurobiology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Association between fronto-limbic-striatal functional network connectivity during emotion processing using data-driven person-specific approach.
Optimal synchronization of directed complex networks
Creators: name: Skardal, Per Sebastian
name: Taylor, Dane
name: Sun, Jie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: We study optimal synchronization of networks of coupled phase oscillators. We extend previous theory for optimizing the synchronization properties of undirected networks to the important case of directed networks. We derive a generalized synchrony alignment function that encodes the interplay between the network structure and the oscillators' natural frequencies and serves as an objective measure for the network's degree of synchronization. Using the generalized synchrony alignment function, we show that a network's synchronization properties can be systematically optimized. This framework also allows us to study the properties of synchrony-optimized networks, and in particular, investigate the role of directed network properties such as nodal in- and out-degrees. For instance, we find that in optimally rewired networks, the heterogeneity of the in-degree distribution roughly matches the heterogeneity of the natural frequency distribution, but no such relationship emerges for out-degrees. We also observe that a network's synchronization properties are promoted by a strong correlation between the nodal in-degrees and the natural frequencies of oscillators, whereas the relationship between the nodal out-degrees and the natural frequencies has comparatively little effect. This result is supported by our theory, which indicates that synchronization is promoted by a strong alignment of the natural frequencies with the left singular vectors corresponding to the largest singular values of the Laplacian matrix.
Transitivity reinforcement in the coevolving voter model
Creators: name: Lee, Hsuan-Wei
name: Shi, Feng
name: Malik, Nishant
name: Mucha, Peter J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: One of the fundamental structural properties of many networks is triangle closure. Whereas the influence of this transitivity on a variety of contagion dynamics has been previously explored, existing models of coevolving or adaptive network systems typically use rewiring rules that randomize away this important property, raising questions about their applicability. In contrast, we study here a modified coevolving voter model dynamics that explicitly reinforces and maintains such clustering. Carrying out numerical simulations for a variety of parameter settings, we establish that the transitions and dynamical states observed in coevolving voter model networks without clustering are altered by reinforcing transitivity in the model. We then use a semi-analytical framework in terms of approximate master equations to predict the dynamical behaviors of the model for a variety of parameter settings.
Oral diseases associated with COVID-19 in adults. Scoping Review.
Creators: name: Astudillo, Jackeline
name: López, Miriam
name: Monrroy, Catherine
name: NAVAS P, RITA
name: Ramos, Ronald
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: adults
subject: COVID-19
subject: oral clinical manifestations
subject: Scoping Review

description: The objective of this scoping review is to identify and map the evidence available in the literature to provide an overview of COVID-19 related oral diseases in adults. The literature review will be carried out in the databases: PubMed, Scopus, Epistemonikos, Web of Science, Springer, Lilacs, Latindex, Redalyc, Imbiomed, Bireme, Scielo; and the reports of the World Health Organization and the Pan-American Health Organization (WHO/PAHO). There will be no limits on languages. The time range for the information search will be from 2020 to marzo 2021.
Incorporating inductances in tissue-scale models of cardiac electrophysiology
Creators: name: Griffith, Boyce E.
name: Rossi, Simone
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: In standard models of cardiac electrophysiology, including the bidomain and monodomain models, local perturbations can propagate at infinite speed. We address this unrealistic property by developing a hyperbolic bidomain model that is based on a generalization of Ohm's law with a Cattaneo-type model for the fluxes. Further, we obtain a hyperbolic monodomain model in the case that the intracellular and extracellular conductivity tensors have the same anisotropy ratio. In one spatial dimension, the hyperbolic monodomain model is equivalent to a cable model that includes axial inductances, and the relaxation times of the Cattaneo fluxes are strictly related to these inductances. A purely linear analysis shows that the inductances are negligible, but models of cardiac electrophysiology are highly nonlinear, and linear predictions may not capture the fully nonlinear dynamics. In fact, contrary to the linear analysis, we show that for simple nonlinear ionic models, an increase in conduction velocity is obtained for small and moderate values of the relaxation time. A similar behavior is also demonstrated with biophysically detailed ionic models. Using the Fenton-Karma model along with a low-order finite element spatial discretization, we numerically analyze differences between the standard monodomain model and the hyperbolic monodomain model. In a simple benchmark test, we show that the propagation of the action potential is strongly influenced by the alignment of the fibers with respect to the mesh in both the parabolic and hyperbolic models when using relatively coarse spatial discretizations. Accurate predictions of the conduction velocity require computational mesh spacings on the order of a single cardiac cell. We also compare the two formulations in the case of spiral break up and atrial fibrillation in an anatomically detailed model of the left atrium, and we examine the effect of intracellular and extracellular inductances on the virtual electrode phenomenon.
title: Prognostic value of preoperative dynamic contrast-enhanced MRI perfusion parameters for high-grade glioma patients
Creators: name: Ulyte, Agne
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Oncology
subject: MR-Diffusion/Perfusion
subject: Staging
subject: Statistics
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: High-grade glioma patient prognosis depends on the clinical, genetic and MR imaging profile of the tumor, including parameters such as perfusion. Dynamic contrast-enhanced (DCE) perfusion is a technique to measure vessel permeability, intravascular...
Ubaldino Peruzzi a Raffaello Busacca (29 giugno 1852)
Creators: name: Peruzzi, Ubaldino
name: Busacca, Raffaello
Publisher: name: Zenodo
Year: 2023
Subjects: Accademia dei Georgofili
Peruzzi, Ubaldino
Busacca, Raffaello
1852
Carteggio
Correspondence
Letter
Lettera

description: Lettera di Ubaldino Peruzzi a Raffaello Busacca del 29 giugno 1852. Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio, Busta 31, 2774. Natura: manoscritto. Consistenza: cc. 2.
description: Digitalizzato come parte della Mostra virtuale: Ubaldino Peruzzi : un percorso in rete : in occasione del bicentenario della nascita https://www.georgofili.it/contenuti/ubaldino-peruzzi-un-percorso-in-rete/17485
title: Submillisievert CT angiography for carotid arteries using new adaptive statistical iterative reconstruction - V
Creators: name: Annoni, Andrea
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Vascular
subject: Head and neck
subject: Radioprotection / Radiation dose
subject: CT-Angiography
subject: Diagnostic procedure
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: CT angiography (CTA) has been demonstrated to be an accurate non-invasive method for detection of atherosclerotic lesions of the carotid arteries and for stenosis evaluation. However patients with carotid atherosclerotic lesions often undergo...
Recurrent Labial Hair Thread Tourniquet Syndrome in an Adolescent Girl: A Systematic Review and Case Report
Creators: name: Lynn, Anna
name: Naomi Adjei, MPH
name: Grimshaw, Alyssa
name: Brault, Marie
name: Vash-Margita, Alla
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Obstetrics and Gynecology
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Pediatrics

description: Systematic Review and Case Report
Juden und Judentum in Katechese und Predigt
Creators: name: Willebrands, Johannes G. M.
name: Duprey, Pierre
name: Mejía, Jorge María
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 39 Nr. 10 (1985): Herder Korrespondenz, Band 39, Heft 10
title: Comparison of quantitative analysis to qualitative analysis for interpretation of lower limb lymphoscintigraphy
Creators: name: Nganga, Edward
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Nuclear medicine
subject: Lymphography
subject: Technical aspects
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Lymphoscintigraphy is now the primary imaging modality used in determining a diagnosis in patients with suspected extremity lymphedema. However, analysis is mainly by visual qualitative analysis which is subjective and has a wide inter-observer...
Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation
Creators: name: Rydeen, Amy E.
name: Brustad, Eric M.
name: Leuthaeuser, Janelle B.
name: Fetrow, Jacquelyn S.
name: Gibson-O'Grady, Evan J.
name: Gober, Joshua G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Cytochrome P450s and other heme-containing proteins have recently been shown to have promiscuous activity for the cyclopropanation of olefins using diazoacetate reagents. Despite the progress made thus far, engineering selective catalysts for all possible stereoisomers for the cyclopropanation reaction remains a considerable challenge. Previous investigations of a model P450 (P450BM3) revealed that mutation of a conserved active site threonine (Thr268) to alanine transformed the enzyme into a highly active and selective cyclopropanation catalyst. By incorporating this mutation into a diverse panel of P450 scaffolds, we were able to quickly identify enantioselective catalysts for all possible diastereomers in the model reaction of styrene with ethyl diazoacetate. Some alanine variants exhibited selectivities that were markedly different from the wild-type enzyme, with a few possessing moderate to high diastereoselectivity and enantioselectivities up to 97 % for synthetically challenging cis-cyclopropane diastereomers.
title: Can we diagnose piriformis muscle syndrome via sonoelastography: preliminary findings of twenty-one patients
Creators: name: Baykara, Murat
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal soft tissue
subject: Elastography
subject: Diagnostic procedure
subject: Pathology

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Piriformis syndrome (PS), is a neuropathy which occurs from either compression or irritation of sciatic nerve by piriformis muscle spasm or contracture. Diagnosis of PS is difficult clinically and can be delayed. This will cause difficulty and more...
A Method to Generate and Analyze Modified Myristoylated Proteins
Creators: name: Yu, Yanbao
name: Chen, Xian
name: Gao, Huanyao
name: Sun, Wei
name: Wang, Li
name: Song, Zhiquan
name: Zhang, Qisheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Covalent lipid modification of proteins is essential to their cellular localizations and functions. Engineered lipid motifs, coupled with bio-orthogonal chemistry, have been utilized to identify myristoylated or palmitoylated proteins in cells. However, whether modified proteins have similar properties as endogenous ones has not been well investigated mainly due to lack of methods to generate and analyze purified proteins. We have developed a method that utilizes metabolic interference and mass spectrometry to produce and analyze modified, myristoylated small GTPase ADP-ribosylation factor 1 (Arf1). The capacities of these recombinant proteins to bind liposomes and load and hydrolyze GTP were measured and compared with the unmodified myristoylated Arf1. The ketone-modified myristoylated Arf1 could be further labeled by fluorophore-coupled hydrazine and subsequently visualized through fluorescence imaging. This methodology provides an effective model system to characterize lipid-modified proteins with additional functions before applying them to cellular systems.
Deriving physical parameters of unresolved star clusters IV. The M33 star cluster system
Creators: name: de Meulenaer, P.
name: Narbutis, D.
name: Mineikis, T.
name: Vansevičius, V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context. When trying to derive the star cluster physical parameters of the M33 galaxy using broad-band unresolved ground-based photometry, previous studies mainly made use of simple stellar population models, shown in the recent years to be oversimplified. Aims. In this study, we aim to derive the star cluster physical parameters (age, mass, and extinction; metallicity is assumed to be LMC-like for clusters with age below 1\,Gyr and left free for older clusters) of this galaxy using models that take stochastic dispersion of cluster integrated colors into account. Methods. We use three recently published M33 catalogs of cluster optical broad-band photometry in standard $UBVRI$ and in CFHT/MegaCam $u^{*}g'r'i'z'$ photometric systems. We also use near-infrared $JHK$ photometry that we derive from deep 2MASS images. We derive the cluster parameters using a method that takes into account the stochasticity problem, presented in previous papers of this series. Results. The derived differential age distribution of the M33 cluster population is composed of a two-slope profile indicating that the number of clusters decreases when age gets older. The first slope is interpreted as the evolutionary fading phase of the cluster magnitudes, and the second slope as the cluster disruption. The threshold between these two phases occurs at $\sim$300\,Myrs, comparable to what is observed in the M31 galaxy. We also model by use of artificial clusters the ability of the cluster physical parameter derivation method to correctly derive the two-slope profile for different photometric systems tested.
description: 12 pages, 10 figures
Temporal Logic as Filtering
Creators: name: Rodionova, Alena
name: Bartocci, Ezio
name: Nickovic, Dejan
name: Grosu, Radu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: F.4.1; D.3.1
subject: 03B44

description: We show that metric temporal logic can be viewed as linear time-invariant filtering, by interpreting addition, multiplication, and their neutral elements, over the (max,min,0,1) idempotent dioid. Moreover, by interpreting these operators over the field of reals (+,*,0,1), one can associate various quantitative semantics to a metric-temporal-logic formula, depending on the filter's kernel used: square, rounded-square, Gaussian, low-pass, band-pass, or high-pass. This remarkable connection between filtering and metric temporal logic allows us to freely navigate between the two, and to regard signal-feature detection as logical inference. To the best of our knowledge, this connection has not been established before. We prove that our qualitative, filtering semantics is identical to the classical MTL semantics. We also provide a quantitative semantics for MTL, which measures the normalized, maximum number of times a formula is satisfied within its associated kernel, by a given signal. We show that this semantics is sound, in the sense that, if its measure is 0, then the formula is not satisfied, and it is satisfied otherwise. We have implemented both of our semantics in Matlab, and illustrate their properties on various formulas and signals, by plotting their computed measures.
description: 10 pages
FRW in quadratic form of $f(T)$ gravitational theories
Creators: name: Nashed, G. G. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We derive asymptote solution of a homogeneous and isotropic universe governed by the quadratic form of the field equation of $f(T)$ gravity. We explain how the higher order of the torsion can provide an origin for late accelerated phase of the universe in the FRW. The solution makes the scalar torsion $T$ to be a function of the cosmic time $t$. We show that for the equation of state $p=ωρ$ with $ω\neq -1$ the scale factor represent late phase of universe. We perform the cosmological studies and show how the quadratic form of $f(T)$ effect on the behavior of these studies.
description: 15 pages Latex, 4 figurs. arXiv admin note: substantial text overlap with arXiv:1403.0913, arXiv:1411.3293; text overlap with arXiv:1501.00621, arXiv:1501.02198, arXiv:1501.00103 by other authors
title: Hypointensity rim of hepatocellular carcinoma on arterial phase of dynamic contrast-enhanced MRI can predict low recurrence rate after hepatectomy
Creators: name: Fujinaga, Yasunari
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Liver
subject: MR
subject: Outcomes analysis
subject: Diagnostic procedure
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Dynamic contrast-enhanced MRI (DCE-MRI) with high temporal resolution using radial volumetric imaging breath-hold examination with k-space weighted image contrast reconstruction (r-VIBE-KWIC) has a diagnostic potential comparable to dynamic CT...
title: Dosimetric advantage of percutaneous femoral artery approach vs radial approach in coronary angiography: preliminary analysis
Creators: name: Aviano, Davide
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Radioprotection / Radiation dose
subject: Cardiac
subject: Fluoroscopy
subject: Catheter arteriography
subject: Dosimetry
subject: Angioplasty
subject: Cardiac Assist Devices

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The aim of our study was to measure radiation dose absorbed by patient and interventional operators during coronary procedures comparing transradial and transfemoral access;using sterile and scattered radiation-absorbing shield-or...
Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex
Creators: name: Keeton, Adam
name: Piazza, Gary Anthony
name: Bauer, Matthias
name: Zhang, Yanping
name: Rezk, Mohamed Salah
name: Hartmann, Rolf Wolfgang
name: Abdel-Halim, Mohammad
name: Franklin, Derek
name: Engel, Matthias
name: Abadi, Ashraf Hassan
name: Boeckler, Frank Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Twelve derivatives of the general formula 3-substituted-6-chloroindoles were synthesized and tested for their growth inhibitory effects versus p53(+/+) colorectal cancer HCT116 and its p53 knockout isogenic cells; colorectal cancer cell p53(-/-) SW480; the lung cancer cell line p53(-/-) H1299; mouse embryonic fibroblasts (MEF) p53(+/+) and its p53 knockout isogenic cells. The compounds were also evaluated for their ability to induce p53 nuclear translocation and binding to murine double minute 2 (MDM2) and murine double minute 4 (MDM4). Of these, compound 5a was the most active in inhibiting the growth of cells, with selectivity towards the p53(+/+) cell lines, and it showed stronger binding to MDM4 rather than MDM2. The activity profile of compound 5a is strongly similar to that of Nutlin-3.
title: Radiolabeled somatostatin receptor agonist versus antagonist for molecular imaging and therapy
Creators: name: Dalm, Simone
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Nuclear medicine
subject: Oncology
subject: SPECT
subject: Radionuclide therapy
subject: Radiation therapy / Oncology

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Radiolabeled somatostatin receptor 2 (SSTR2) agonists are successfully used in the clinic for the imaging and therapy of neuroendocrine tumours. 1,2 Although imaging and therapy results with SSTR2 radioligands are positive, there is room for...
Health needs of non-camp-based refugees in MENA scoping review
Creators: name: Abdelrazik, Bassante
name: Maxwell, Lauren
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Medicine and Health Sciences

description: A scoping review aiming to highlight the health needs of refugees in the Middle East and North Africa region. Further leading to an overall broad assessment of refugee’s situation with regards to access to healthcare in the MENA region and their most pressing needs in the past 10 years where the refugees crisis has been a major issue in this region.
A Novel Clerodane Diterpene from Vitex cofassus
Creators: name: Atsumi, Toshiyuki
name: Rasyid, Faradiba Abdul
name: Nakagawa-Goto, Kyoko
name: Goto, Masuo
name: Ando, Hirokazu
name: Sasaki, Yohei
name: Saito, Yohei
name: Fujie, Tetsuo
name: Miyake, Katsunori
name: Fukuyoshi, Shuichi
name: Mikage, Masayuki
name: Shinya, Tomohiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC50 values of 5.4-11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis.
Black Ring and Kerr Ellipsoid - Solitonic Configurations in Modified Finsler Gravity
Creators: name: Rajpoot, Subhash
name: Vacaru, Sergiu I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study an effective Einstein-Finsler theory on tangent Lorentz bundle constructed as a "minimal" extension of general relativity. Black ring and Kerr like ellipsoid exact solutions and soliton configurations are presented. In this endeavor the relevant metric depends not only on four dimensional spacetime coordinates and also on velocity type variables that can be interpreted as additional coordinates in the space of "extra dimensions".
description: 15 pages, latex 2e; version accepted on 25 May 2015 by IJGMMP
title: Социальная работа с молодой семьей
title: Учебное пособие
titleType: Subtitle
Creators: name: Рыбак Е.В.
name:  Федулова А.Б.
name:  Цихончик Н.В.
Publisher: name: Ай Пи Эр Медиа
Year: 2019

description: В учебном пособии представлены теоретические и методологические подходы к социальной работе с молодыми семьями, методические материалы, технологии, результаты практического опыта специалистов. В свете новых научных парадигм и стратегий, особое внимание в издании отводится профилактической составляющей социальной работы с молодежью. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов вузов, обучающихся по направлениям подготовки 39.03.02 «Социальная работа», 39.04.02 «Социальная работа», 39.03.03 «Организация работы с молодежью», 44.03.02 «Психолого-педагогическое образование». Пособие также может быть полезным специалистам по работе с молодежью, социальной работе с семьей; социальным педагогам, педагогам образовательных учреждений, работающим с молодыми родителями, их детьми.
description: The textbook presents the theoretical and methodological approaches to social work with young families, instructional materials, technology, results practical experience. In the light of new scientific paradigms and strategies, special attention in the publication is given to the preventive component of social work with young people. Prepared in accordance with the requirements of Federal state educational standard of higher education. The textbook is designed for students studying in areas of training 39.03.02 Social work, 39.04.02 Social work, 39.03.03 "Organization of work with young people," 44.03.02 "Psycho-pedagogical education". The Handbook can also be useful to specialists in youth work, social work with family; social teachers, teachers of educational institutions working with young parents, their children.
Refugees in Ukraine and the perception of war
Creators: name: Burcea, Marin
name: Lătăianu, Gabriel
name: Stefan, Bruno
Publisher: name: figshare
Year: 2023
Subjects: Sociology of migration, ethnicity and multiculturalism

description: The survey was conducted between March 9-20, 2022 on a sample of 800 people living in 220 urban and regional localities in all counties of Romania, with a statistical error of +/- 3.5%. He measured the attitude of Romanians towards refugees from Ukraine, but also from other geographical regions. Compared to the similar research in October 2021, there was a 25% increase in the favorable attitude towards refugees, and it is the highest increase among young people, those with higher education, employers, those living in very large cities. Romanians are favorable to the entry of refugees from Ukraine and hypothetically from Moldova, but more reluctant to those from Asia, Africa, Latin America or the Caucasus. Romanians’ self-esteem has significantly increased for the exemplary way in which their fellow citizens have been involved in helping refugees in Ukraine, although they are aware that there is a risk of upsetting the Russian Federation.
UCOM - Parental Leave Gap Model
Creators: name: Block, Katharina
name: Schmader, Toni
name: Van Grootel, Sanne
name: olsson, maria
name: Meeussen, Loes
name: Martiny, Sarah
name: Schuster, Carolin
name: Wee, Sheila
name: Sun, Molly
name: van Laar, Colette
name: Croft, Alyssa
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: communal
subject: cross-cultural
subject: gender roles
subject: men

description: We hereby pre-register a model, which is part of the project Understanding Communal Orientation in Men (UCOM)
Cyclopentadiene-mediated hydride transfer from rhodium complexes
Creators: name: Finster,
name: Pitman,
name: Miller,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Attempts to generate a proposed rhodium hydride catalytic intermediate instead resulted in isolation of (Cp*H)Rh(bpy)Cl ( 1 ), a pentamethylcyclopentadiene complex, formed by C–H bond-forming reductive elimination from the fleeting rhodium hydride.
Exploring Effects of Current and Childhood Resources 01-2021
Creators: name: Grillo, Tito
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: This preregistration contains information about an exploratory study conducted with undergraduate students from the University of Texas at Austin. The goal of the study was to explore the predictive role of variables related to childhood and current resources in understanding risky behavior/risk-preferences, financial behavior, and self-efficacy in the contexts of the COVID-19 pandemic and personal finances.
Stability of self-gravitating Bose-Einstein-Condensates
Creators: name: Schroven, Kris
name: List, Meike
name: Lämmerzahl, Claus
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the ground state and the first three radially excited states of a self-gravitating Bose-Einstein- Condensate with respect to the influence of two external parameters, the total mass and the strength of interactions between particles. For this we use the so-called Gross-Pitaevskii-Newton system. In this context we especially determine the case of very high total masses where the ground state solutions of the Gross-Pitaevskii- Newton system can be approximated with the Thomas-Fermi limit. Furthermore, stability properties of the computed radially excited states are examined by applying arguments of the catastrophe theory.
description: 11 pages, 9 figures
title: Local hepatic tumour control in patients with HCC undergoing transarterial lipiodol embolisation followed by microwave ablation
Creators: name: Seidel, Roland
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional non-vascular
subject: Oncology
subject: Liver
subject: MR-Functional imaging
subject: Cone beam CT
subject: CT-Angiography
subject: Ablation procedures
subject: Embolisation
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To retrospectively investigate local tumor control in patients with HCC undergoing lipiodol embolization and subsequent microwave...
title: Changes of mental imaginary motor task fMRI activation in chronic spinal cord injury treated by intrathecal baclofen
Creators: name: Keller, Jirí
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Trauma
subject: MR-Functional imaging
subject: Statistics
subject: Trauma

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Increased muscle activity is a frequent sign of upper motor neuron syndrome in chronic spinal cord injury (SCI). In severe cases, intrathecal baclofen (ITB) administration is recommended [1,2]. This GABA-B agonist ( Fig. 1 ) actiavtes spinal as well...