cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Budding Yeast Chromosome Structure and Dynamics during Mitosis
Creators: name: Pearson, Chad G.
name: Bloom, Kerry
name: Salmon, E.D.
name: Maddox, Paul S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Using green fluorescent protein probes and rapid acquisition of high-resolution fluorescence images, sister centromeres in budding yeast are found to be separated and oscillate between spindle poles before anaphase B spindle elongation. The rates of movement during these oscillations are similar to those of microtubule plus end dynamics. The degree of preanaphase separation varies widely, with infrequent centromere reassociations observed before anaphase. Centromeres are in a metaphase-like conformation, whereas chromosome arms are neither aligned nor separated before anaphase. Upon spindle elongation, centromere to pole movement (anaphase A) was synchronous for all centromeres and occurred coincident with or immediately after spindle pole separation (anaphase B). Chromatin proximal to the centromere is stretched poleward before and during anaphase onset. The stretched chromatin was observed to segregate to the spindle pole bodies at rates greater than centromere to pole movement, indicative of rapid elastic recoil between the chromosome arm and the centromere. These results indicate that the elastic properties of DNA play an as of yet undiscovered role in the poleward movement of chromosome arms.
Local Photorelease of Caged Thymosin β4 in Locomoting Keratocytes Causes Cell Turning
Creators: name: Loew, Leslie
name: Jones, David
name: Marriott, Gerard
name: Rajfur, Zenon
name: Jacobson, Ken
name: Roy, Partha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The broad aim of this work was to explore the feasibility of using light-directed perturbation techniques to study cell locomotion. Specifically, a caged form of thymosin β4 (Tβ4) was photoactivated in a defined local region of locomoting fish scale keratocytes and the resulting perturbation of locomotion was studied. Purified Tβ4 was produced in an inactive form by “caging” with ([n-nitroveratryl]oxy)chlorocarbamate. In vitro spectrophotofluorometric assays indicated that caged Tβ4 did not change the normal actin polymerization kinetics, whereas photoactivated Tβ4 significantly inhibited actin polymerization. With an a priori knowledge of the cytoplasmic diffusion coefficient of Tβ4 as measured by fluorescence recovery after photobleaching experiments, the rapid sequestration of actin monomers by uncaged Tβ4 and the consequent reduction in the diffusional spread of the Tβ4–actin complex were predicted using Virtual Cell software (developed at the Center for Biomedical Imaging Technology, University of Connecticut Health Center). These simulations demonstrated that locally photoactivating Tβ4 in keratocytes could potentially elicit a regional locomotory response. Indeed, when caged Tβ4 was locally photoactivated at the wings of locomoting keratocytes, specific turning about the irradiated region was observed, whereas various controls were negative. Additionally, loading of exogenous Tβ4 into both keratocytes and fibroblasts caused very rapid disassembly of actin filaments and reduction of cellular contractility. Based on these results, a mechanical model is proposed for the turning behavior of keratocytes in response to photoreleased Tβ4.
Efficacy of social cognition and interaction training in outpatients with schizophrenia spectrum disorders: randomized controlled trial
Creators: name: Davidson C.A.
name: Roberts D.L.
name: Fiszdon J.M.
name: Penn D.L.
name: Dixon H.D.
name: Bell M.D.
Publisher: name: Frontiers Media SA
Year: 2023

description: Given the relationship between social cognition and functional outcome in schizophrenia, a number of social cognitive interventions have been developed, including Social Cognition Interaction Training (SCIT), a group-based, comprehensive, manualized intervention. In the current trial, we examined SCIT efficacy as well as potential moderators of treatment effects. Fifty-one outpatients were randomized to SCIT or a wait-list-control (WLC), with assessments of social cognition, neurocognition, self-report, symptoms, and functioning conducted at baseline and end of the active phase. Relative to WLC, we did not find significant improvements for SCIT on neurocognition, social cognition, self-report, or symptoms, though there was a trend-level, medium effect favoring the SCIT condition on interpersonal and instrumental role function. Post-hoc analyses indicated that baseline neurocognition did not impact degree of social cognitive or functional change. Shorter duration of illness was significantly associated with better post-training neurocognition and self-esteem and, at trend-level with better symptoms and social functioning. We discuss the importance of outcome measure selection and the need for continued evaluation of potential treatment moderators in order to better match people to existing treatments. Clinical trial registration: Clinicaltrials.gov, Identifier NCT00587561.
An Egocentric Look at Video Photographer Identity
Creators: name: Hoshen, Yedid
name: Peleg, Shmuel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Egocentric cameras are being worn by an increasing number of users, among them many security forces worldwide. GoPro cameras already penetrated the mass market, reporting substantial increase in sales every year. As head-worn cameras do not capture the photographer, it may seem that the anonymity of the photographer is preserved even when the video is publicly distributed. We show that camera motion, as can be computed from the egocentric video, provides unique identity information. The photographer can be reliably recognized from a few seconds of video captured when walking. The proposed method achieves more than 90% recognition accuracy in cases where the random success rate is only 3%. Applications can include theft prevention by locking the camera when not worn by its rightful owner. Searching video sharing services (e.g. YouTube) for egocentric videos shot by a specific photographer may also become possible. An important message in this paper is that photographers should be aware that sharing egocentric video will compromise their anonymity, even when their face is not visible.
Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton: Figure 1.
Creators: name: Aplin, Andrew E.
name: Juliano, R.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regulate the trafficking of signaling proteins between the cytoplasm and nucleus. Cell adhesion molecule control of nucleocytoplasmic trafficking allows adhesion to influence many cell decisions, and highlights the diversity of nuclear import and export mechanisms.
Diversity and recognition in research teams
Creators: name: Robinson-Garcia, Nicolas
Publisher: name: Zenodo
Year: 2024
Subjects: team science
researchers
research careers
scientometrics
science of science
local research

description: Evaluative processes struggle with the notion of diversity and the introduction of team-level approaches. This is because metrics rely solely on authorship as the means of attributing and distributing credit. The notion of a behaviourist attitude towards the reward system of science is contradicted by evidence suggesting that scientists behave in ways that can potentially be detrimental to their own career prospects. In this talk I will be presenting and discussing our findings with regard to the use of scientometric methods to analyze and study team diversity. We will be discussing how research teams are defined and operationalized and the consequences task distribution may have for specific individuals affecting their research career prospects. Furthermore, we will look into aspects such as gender or nationality to which science is socially biased affecting negatively specific cohorts of the scientific workforce.
Refined Algorithms to Compute Syzygies
Creators: name: Erocal, Burcin
name: Motsak, Oleksandr
name: Schreyer, Frank-Olaf
name: Steenpass, Andreas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Commutative Algebra (math.AC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14Q99 (Primary), 13D02, 13P20 (Secondary)

description: Based on Schreyer's algorithm (Schreyer, 1980, 1991; Berkesch and Schreyer, 2014), we present two refined algorithms for the computation of syzygies. The two main ideas of the first algorithm, called LiftHybrid, are the following: First, we may leave out certain terms of module elements during the computation which do not contribute to the result. These terms are called "lower order terms", see Definition 4.2. Second, we do not need to order the remaining terms of these module elements during the computation. This significantly reduces the number of monomial comparisons for the arithmetic operations. For the second algorithm, called LiftTree, we additionally cache some partial results and reuse them at the remaining steps.
description: 25 pages, 18 tables, 5 figures
Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders
Creators: name: McLarnan S.M.
name: Zhang S.
name: Baker B.H.
name: Pearson B.L.
name: Simon J.M.
name: Chung W.K.
Publisher: name: Frontiers Media SA
Year: 2023

description: Introduction: De novo mutations contribute to a large proportion of sporadic psychiatric and developmental disorders, yet the potential role of environmental carcinogens as drivers of causal de novo mutations in neurodevelopmental disorders is poorly studied. Methods: To explore environmental mutation vulnerability of disease-associated gene sets, we analyzed publicly available whole genome sequencing datasets of mutations in human induced pluripotent stem cell clonal lines exposed to 12 classes of environmental carcinogens, and human lung cancers from individuals living in highly polluted regions. We compared observed rates of exposure-induced mutations in disease-related gene sets with the expected rates of mutations based on control genes randomly sampled from the genome using exact binomial tests. To explore the role of sequence characteristics in mutation vulnerability, we modeled the effects of sequence length, gene expression, and percent GC content on mutation rates of entire genes and gene coding sequences using multivariate Quasi-Poisson regressions. Results: We demonstrate that several mutagens, including radiation and polycyclic aromatic hydrocarbons, disproportionately mutate genes related to neurodevelopmental disorders including autism spectrum disorders, schizophrenia, and attention deficit hyperactivity disorder. Other disease genes including amyotrophic lateral sclerosis, Alzheimer’s disease, congenital heart disease, orofacial clefts, and coronary artery disease were generally not mutated more than expected. Longer sequence length was more strongly associated with elevated mutations in entire genes compared with mutations in coding sequences. Increased expression was associated with decreased coding sequence mutation rate, but not with the mutability of entire genes. Increased GC content was associated with increased coding sequence mutation rates but decreased mutation rates in entire genes. Discussion: Our findings support the possibility that neurodevelopmental disorder genetic etiology is partially driven by a contribution of environment-induced germ line and somatic mutations.
Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions
Creators: name: Popko, Brian
name: Marcus, Jill
name: Dupree, Jeffrey L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: We have analyzed mice that lack both the myelin-associated glycoprotein (MAG) and the myelin galactolipids, two glial components implicated in mediating axo-glial interactions during the myelination process. The single-mutant mice produce abnormal myelin containing similar ultrastructural abnormalities, suggesting that these molecules may play an overlapping role in myelin formation. Furthermore, the absence of the galactolipids results in a disruption in paranodal axo-glial interactions, and we show here that similar, albeit less severe, abnormalities exist in the developing MAG mutant. In the double-mutant mice, maintenance of axo-glial adhesion is significantly more affected than in the single mutants, supporting the overlapping function hypothesis. We also show that independently of MAG, galactolipids, and paranodal junctional components, immature nodes of Ranvier form normally, but rapidly destabilize in their absence. These data indicate that distinct molecular mechanisms are responsible for the formation and maintenance of axo-glial interactions.
Additional file 1 of A multidisciplinary opioid-reduction pathway for robotic prostatectomy: outcomes at year one
Creators: name: Manning, Michael W.
name: Whittle, John
name: Fuller, Matthew
name: Cooper, Sara H.
name: Manning, Erin L.
name: Chapman, Joe
name: Moul, Judd W.
name: Miller, Timothy E.
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Neuroscience
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1: Table 1. Opioid Free Pathway during the perioperative period. Table 2. Script elements to align expectations for OFA in Robotic Prostatectomies.
On the duality in CPT-even Lorentz-breaking theories
Creators: name: Scarpelli, A. P. Baeta
name: Nascimento, J. R.
name: Petrov, A. Yu.
name: Ribeiro, R. F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, we generalize the duality between self-dual and Maxwell-Chern-Simons theories for the case of a CPT-even Lorentz-breaking extension of these theories. The duality is demonstrated with use of the gauge embedding procedure, both in free and coupled cases, and with the master action approach. The physical spectra of both Lorentz-breaking theories are studied. The massive poles are shown to coincide and to respect the requirements for unitarity and causality at tree level. The extra massless poles which are present in the dualized model are shown to be nondynamical.
description: 17 pages, version accepted to EPJC
Exploring the evolution and function of Canoe’s intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis
Creators: name: Szymanski R.A.
name: Butcher T.A.
name: Peifer M.
name: Dowen R.H.
name: Gurley N.J.
name: Ishiyama N.
Publisher: name: Public Library of Science
Year: 2023

description: One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway. We focus on Drosophila Canoe, homolog of mammalian Afadin, as a model for defining the underlying mechanisms. Canoe and Afadin are complex, multidomain proteins that share multiple domains with defined and undefined binding partners. Both also share a long carboxy-terminal intrinsically disordered region (IDR), whose function is less well defined. IDRs are found in many proteins assembled into large multiprotein complexes. We have combined bioinformatic analysis and the use of a series of canoe mutants with early stop codons to explore the evolution and function of the IDR. Our bioinformatic analysis reveals that the IDRs of Canoe and Afadin differ dramatically in sequence and sequence properties. When we looked over shorter evolutionary time scales, we identified multiple conserved motifs. Some of these are predicted by AlphaFold to be alpha-helical, and two correspond to known protein interaction sites for alpha-catenin and F-actin. We next identified the lesions in a series of eighteen canoe mutants, which have early stop codons across the entire protein coding sequence. Analysis of their phenotypes are consistent with the idea that the IDR, including the conserved motifs in the IDR, are critical for protein function. These data provide the foundation for further analysis of IDR function. © 2023 Gurley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fine-grained functional parcellation maps of the infant cerebral cortex
Creators: name: Lin W.
name: Zhou Z.
name: Wu Z.
name: Zhang H.
name: Girault J.B.
name: Li G.
name: Wang L.
name: Hu D.
name: Wang F.
Publisher: name: eLife Sciences Publications Ltd
Year: 2023

description: Resting-state functional MRI (rs-fMRI) is widely used to examine the dynamic brain functional development of infants, but these studies typically require precise cortical parcellation maps, which cannot be directly borrowed from adult-based functional parcellation maps due to the substantial differences in functional brain organization between infants and adults. Creating infant-specific cortical parcellation maps is thus highly desired but remains challenging due to difficulties in acquiring and processing infant brain MRIs. In this study, we leveraged 1064 high-resolution longitudinal rs-fMRIs from 197 typically developing infants and toddlers from birth to 24 months who participated in the Baby Connectome Project to develop the first set of infant-specific, fine-grained, surface-based cortical functional parcellation maps. To establish meaningful cortical functional correspondence across individuals, we performed cortical co-registration using both the cortical folding geometric features and the local gradient of functional connectivity (FC). Then we generated both age-related and age-independent cortical parcellation maps with over 800 fine-grained parcels during infancy based on aligned and averaged local gradient maps of FC across individuals. These parcellation maps reveal complex functional developmental patterns, such as changes in local gradient, network size, and local efficiency, especially during the first 9 postnatal months. Our generated fine-grained infant cortical functional parcellation maps are publicly available at https://www.nitrc.org/projects/infantsurfatlas/ for advancing the pediatric neuroimaging field.
Phospholipids undergo hop diffusion in compartmentalized cell membrane
Creators: name: Kusumi, Akihiro
name: Fujiwara, Takahiro
name: Jacobson, Ken
name: Ritchie, Ken
name: Murakoshi, Hideji
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The diffusion rate of lipids in the cell membrane is reduced by a factor of 5–100 from that in artificial bilayers. This slowing mechanism has puzzled cell biologists for the last 25 yr. Here we address this issue by studying the movement of unsaturated phospholipids in rat kidney fibroblasts at the single molecule level at the temporal resolution of 25 μs. The cell membrane was found to be compartmentalized: phospholipids are confined within 230-nm-diameter (φ) compartments for 11 ms on average before hopping to adjacent compartments. These 230-nm compartments exist within greater 750-nm-φ compartments where these phospholipids are confined for 0.33 s on average. The diffusion rate within 230-nm compartments is 5.4 μm2/s, which is nearly as fast as that in large unilamellar vesicles, indicating that the diffusion in the cell membrane is reduced not because diffusion per se is slow, but because the cell membrane is compartmentalized with regard to lateral diffusion of phospholipids. Such compartmentalization depends on the actin-based membrane skeleton, but not on the extracellular matrix, extracellular domains of membrane proteins, or cholesterol-enriched rafts. We propose that various transmembrane proteins anchored to the actin-based membrane skeleton meshwork act as rows of pickets that temporarily confine phospholipids.
Home Telemonitoring Program in Individuals with COPD During the Coronavirus Disease 2019 Pandemic: A Pilot Study
Creators: name: Rydberg, Michael
name: Johnson, Erica
name: Burkett, Pete
name: Drummond, M. Bradley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: There has been significant interest in innovative ways to improve care of COPD patients. Remote patient monitoring (RPM), also called telemonitoring, is a method of healthcare delivery that gathers patient data outside of traditional healthcare settings. The COVID-19 pandemic has moved telemedicine to the forefront of care, accelerating the need to study remote monitoring in COPD patients. RPM tools including home spirometry, pulse oximetry and daily questionnaires have been shown to have potential to detect AECOPD earlier and improve patient-reported outcomes in COPD. Given the older age and numerous comorbid conditions of many COPD patients, it remains unclear if RPM interventions are feasible and acceptable by this patient population. To address this, we conducted a 12-week pilot study of a novel in-home telemonitoring system, consisting of three components: home spirometer, Bluetooth®-enabled home pulse oximeter, and tablet-based data collection system with avatar-assisted technology with the goal of determining impact on COPD Assessment Test (CAT) score and adherence to device measurements. The study was designed to be conducted entirely remotely given the Coronavirus disease-19 (COVID-19) pandemic.
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
Creators: name: DeMali, K. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Cell migration involves many steps, including membrane protrusion and the development of new adhesions. Here we have investigated whether there is a link between actin polymerization and integrin engagement. In response to signals that trigger membrane protrusion, the actin-related protein (Arp)2/3 complex transiently binds to vinculin, an integrin-associated protein. The interaction is regulated, requiring phosphatidylinositol-4,5-bisphosphate and Rac1 activation, and is sufficient to recruit the Arp2/3 complex to new sites of integrin aggregation. Binding of the Arp2/3 complex to vinculin is direct and does not depend on the ability of vinculin to associate with actin. We have mapped the binding site for the Arp2/3 complex to the hinge region of vinculin, and a point mutation in this region selectively blocks binding to the Arp2/3 complex. Compared with WT vinculin, expression of this mutant in vinculin-null cells results in diminished lamellipodial protrusion and spreading on fibronectin. The recruitment of the Arp2/3 complex to vinculin may be one mechanism through which actin polymerization and membrane protrusion are coupled to integrin-mediated adhesion.
Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component
Creators: name: Cavallo, Robert
name: Myster, Steven H.
name: Anderson, Charles T.
name: Peifer, Mark
name: Fox, Donald T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Cadherin–catenin complexes, localized to adherens junctions, are essential for cell–cell adhesion. One means of regulating adhesion is through the juxtamembrane domain of the cadherin cytoplasmic tail. This region is the binding site for p120, leading to the hypothesis that p120 is a key regulator of cell adhesion. p120 has also been suggested to regulate the GTPase Rho and to regulate transcription via its binding partner Kaiso. To test these hypothesized functions, we turned to Drosophila, which has only a single p120 family member. It localizes to adherens junctions and binds the juxtamembrane region of DE-cadherin (DE-cad). We generated null alleles of p120 and found that mutants are viable and fertile and have no substantial changes in junction structure or function. However, p120 mutations strongly enhance mutations in the genes encoding DE-cadherin or Armadillo, the β-catenin homologue. Finally, we examined the localization of p120 during embryogenesis. p120 localizes to adherens junctions, but its localization there is less universal than that of core adherens junction proteins. Together, these data suggest that p120 is an important positive modulator of adhesion but that it is not an essential core component of adherens junctions.
Impact of the COVID-19 pandemic on delays in diagnosis and treatment of tick-borne diseases endemic to southeastern USA
Creators: name: Tyrlik, Katherine
name: Giandomenico, Dana
name: Arahirwa, Victor
name: Abernathy, Haley
name: Boyce, Ross M.
name: Cassidy, Caitlin
name: Mansour, Odai
name: Brown Marusiak, Amanda
name: Alejo, Aidin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: BACKGROUND: The Coronavirus disease 2019 (COVID-19) pandemic was marked by an increase in diagnosis and treatment delays for a range of medical conditions. Yet the impact of the pandemic on the management of tick-borne diseases, which frequently manifest as an acute febrile illness similar to COVID-19, has not been well described. METHODS: In this retrospective cohort study of patients with suspected tick-borne disease attending the University of North Carolina Health facilities, we compared the timeliness of diagnosis and treatment in a "pre-COVID" period (March 2019 to February 2020) and a "post-COVID" period (March 2020 to February 2021). Participants included patients with an ICD-10 diagnosis code of spotted fever group rickettsiosis or ehrlichiosis and a positive Rickettsia rickettsii or Ehrlichia indirect immunofluorescence assay immunoglobulin G antibody test result. Of the 897 patients who had an eligible diagnosis, 240 (26.8%) met the inclusion criteria. The main outcome was time from initial presentation to definitive diagnosis and treatment. RESULTS: During the 2-year study period, 126 (52.5%) patients were grouped in the pre-COVID period and 114 (47.5%) were grouped in the post-COVID period; 120 (50.0%) were female; and 139 (57.9%) were aged > 50 years. Comparing the post-COVID to the pre-COVID period, the adjusted odds ratio (aOR) for delay in treatment > 0 days was 1.81 (95% confidence interval [CI] 1.07-3.07, P = 0.03), and for a treatment delay > 7 days, 1.65 (95% CI 0.94-2.90, P = 0.08). The odds of a delay in diagnosis were similar for patients in the post- and pre-COVID periods, with an aOR of 1.61 (95% CI 0.96-2.72, P = 0.07) for delays > 0 days, and aOR of 1.72 (95% CI 0.99-3.00, P = 0.05) for delays > 7 days. CONCLUSIONS: The odds of a delay in treatment > 0 days were significantly higher in the post-COVID period than in the pre-COVID period. However, the odds of a delay in treatment > 7 days, or a delay in diagnosis, were similar between these two periods. Shifts in care-seeking, alternative care delivery models and prioritization of COVID-19 may contribute to diminished timeliness of treatment for patients with tick-borne diseases.
Neutrinos from Extra-Large Hadron Collider in the Milky Way
Creators: name: Neronov, Andrii
name: Semikoz, Dmitry
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Neutrino telescope IceCube has recently discovered astrophysical neutrinos with energies in the TeV-PeV range. We use the data of Fermi gamma-ray telescope to demonstrate that the neutrino signal has significant contribution from the Milky Way galaxy. Matching the gamma-ray and neutrino spectra we find that TeV-PeV Galactic cosmic rays form a powerlaw spectrum with the slope p~2.45. This spectral slope is consistent with the average cosmic ray spectrum in the disks of the Milky Way and Large Magellanic Cloud galaxies. It is also consistent with the theoretical model of cosmic ray injection by diffusive shock acceleration followed by escape through the Galactic magnetic field with Kolmogorov turbulence. The locally observed TeV-PeV cosmic ray proton spectrum is softer than the average Galactic cosmic ray spectrum. This could be readily explained by variability of injection of cosmic rays in the local interstellar medium over the past 1e7 yr and discreetness of the cosmic ray source distribution.
description: 6 pages 3 figures, accepted to Astroparticle Physics
Variational Monte Carlo Method in the Presence of Spin-Orbit Interaction and Its Application to the Kitaev and Kitaev-Heisenberg Model
Creators: name: Kurita, Moyuru
name: Yamaji, Youhei
name: Morita, Satoshi
name: Imada, Masatoshi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We propose an accurate variational Monte Carlo method applicable in the presence of the strong spin-orbit interaction. Our variational wave functions consist of generalized Pfaffian-Slater wave functions that involve mixtures of singlet and triplet Cooper pairs, Jastrow-Gutzwiller-type pro- jections, and quantum number projections. The generalized wave functions allow any symmetry breaking states, ranging from magnetic and/or charge ordered states to superconducting states and their fluctuations, on equal footing without any ad hoc ansatz for variational wave functions. We de- tail our optimization scheme for the generalized Pfaffian-Slater wave functions with complex-number variational parameters. Generalized quantum number projections are also introduced, which im- poses the conservation of not only spin and momentum quantum numbers but also Wilson loops. As a demonstration of the capability of the present variational Monte Carlo method, the accuracy and efficiency of the present method is tested for the Kitaev and Kitaev-Heisenberg models. The Kitaev model serves as a critical benchmark of the present method: The exact ground state of the model is a typical gapless quantum spin liquid far beyond the applicability range of simple mean-field wave functions. The newly introduced quantum number projections precisely reproduce the ground state degeneracy of the Kitaev spin liquids, in addition to their ground state energy. Our framework offers accurate solutions for the systems where strong electron correlation and spin-orbit interaction coexist.
description: 12pages, 5 figures
Additional file 1 of Exploring the contribution of case study research to the evidence base for occupational therapy: a scoping review
Creators: name: McQuaid, Leona
name: Thomson, Katie
name: Bannigan, Katrina
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.
On inversion sets and the weak order in Coxeter groups
Creators: name: Hohlweg, Christophe
name: Labbé, Jean-Philippe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 20F55, Secondary 06B23, 05E15

description: In this article, we investigate the existence of joins in the weak order of an infinite Coxeter group W. We give a geometric characterization of the existence of a join for a subset X in W in terms of the inversion sets of its elements and their position relative to the imaginary cone. Finally, we discuss inversion sets of infinite reduced words and the notions of biconvex and biclosed sets of positive roots.
description: 22 pages; 10 figures; v2 some references were added; v2: final version, to appear in European Journal of Combinatorics
Hydrachna Muller 1776
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydrachnidae
Hydrachna

description: Genus Hydrachna Müller, 1776
Records not classified to species level from the study area: Bengal—K. Viets (1926a, b).
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 4, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Fiber bundle description of number scaling in gauge theory and geometry
Creators: name: Benioff, Paul
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This work uses fiber bundles as a framework to describe some effects of number scaling on gauge theory and some geometric quantities. A description of number scaling and fiber bundles over a flat space time manifold, M, is followed by a description of gauge theory. A fiber at point x of M contains a pair of scaled complex number and vector space structures, $C^{c}_{x}\times V^{c}_{x} $ for each c in GL(1,C). A space time dependent scalar field, g, determines, for each x, the scaling value of the vector space structures that contain the values of a vector valued matter field at x. The vertical components of connections between neighboring fibers are taken to be the gradient field A(x)+iB(x), of g. Abelian gauge theory for these fields gives the result that B is massless and no mass restrictions for A. Addition of an electromagnetic field dies not change these results. In the Mexican hat Higgs mechanism B combines with a Goldstone boson to create massive vector bosons, the photon field, and the Higgs field. For geometric quantities the fiber bundle is a tangent bundle with a fiber at point x containing scaled pairs, $R^{r}_{x}\times T^{r}_{x}$ of real number and tangent space structures for each x and and nonnegative real r. B is zero everywhere. The A field affects path lengths and the proper times of clocks along paths. It also appears in the geodesic equation. The lack of physical evidence for the gradient field, A(x)+iB(x) means that it either couples very weakly to matter fields or that it is close to zero for all x in a local region of cosmological space and time. It says nothing about the values outside the local region.
description: 21 pages, 1 figure; extensive revision of first version, errors corrected
RhoA is required for cortical retraction and rigidity during mitotic cell rounding
Creators: name: Maddox, Amy Shaub
name: Burridge, Keith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Mitotic cell rounding is the process of cell shape change in which a flat interphase cell becomes spherical at the onset of mitosis. Rearrangement of the actin cytoskeleton, de-adhesion, and an increase in cortical rigidity accompany mitotic cell rounding. The molecular mechanisms that contribute to this process have not been defined. We show that RhoA is required for cortical retraction but not de-adhesion during mitotic cell rounding. The mitotic increase in cortical rigidity also requires RhoA, suggesting that increases in cortical rigidity and cortical retraction are linked processes. Rho-kinase is also required for mitotic cortical retraction and rigidity, indicating that the effects of RhoA on cell rounding are mediated through this effector. Consistent with a role for RhoA during mitotic entry, RhoA activity is elevated in rounded, preanaphase mitotic cells. The activity of the RhoA inhibitor p190RhoGAP is decreased due to its serine/threonine phosphorylation at this time. Cumulatively, these results suggest that the mitotic increase in RhoA activity leads to rearrangements of the cortical actin cytoskeleton that promote cortical rigidity, resulting in mitotic cell rounding.
Additional file 2 of Exploring the contribution of case study research to the evidence base for occupational therapy: a scoping review
Creators: name: McQuaid, Leona
name: Thomson, Katie
name: Bannigan, Katrina
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Search strategy.
The jet-ISM interaction in the Outer Filament of Centaurus A
Creators: name: Santoro, F.
name: Oonk, J. B. R.
name: Morganti, R.
name: Oosterloo, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences
subject: 85A99

description: The interaction between the radio plasma ejected by the active nucleus of a galaxy and the surrounding medium is a key process that can have a strong impact on the interstellar medium of the galaxy and hence on galaxy evolution. The closest laboratory where we can observe and investigate this phenomenon is the radio galaxy Centaurus A. About 15 kpc north-east of this galaxy, a particularly complex region is found: the so-called Outer Filament where jet-cloud interactions have been proposed to occur. We investigate the presence of signatures of jet-ISM interaction by a detailed study of the kinematics of the ionized gas, expanding on previous results obtained from the HI. We observed two regions of the outer filament with VLT/VIMOS in the IFU observing mode. Emission from Hbeta and [OIII]4959,5007Å is detected in both pointings. We found two distinct kinematical components of ionized gas that well match the kinematics of the nearby HI cloud. One component follows the regular kinematics of the rotating gas while the second shows similar velocities to those of the nearby HI component thought to be disturbed by an interaction with the radio jet. We suggest that the ionized and atomic gas are part of the same dynamical gas structure originating as result of the merger that shaped Centaurus A and which is regularly rotating around Centaurus A as proposed by other authors. The gas (ionized and HI) with anomalous velocities is tracing the interaction of the Large-Scale radio Jet with the ISM, suggesting that, although poorly collimated as structure, the jet is still active. However, we can exclude that a strong shock is driving the ionization of the gas. It is likely that a combination of jet entrainment and photoionization by the UV continuum from the central engine is needed in order to explain both the ionization and the kinematics of the gas in the Outer Filament.
description: 6 pages, 6 figures, 1 table. Final version accepted for publication on A&A
การสร้างกระบวนการและกลไกการมีส่วนร่วมในการจัดทำแผนชุมชนเพื่อส่งเสริมสินค้าพื้นถิ่น กรณีศึกษาพื้นที่ตำบลกุดหว้า อำเภอกุฉินารายณ์ จังหวัดกาฬสินธุ์
Creators: name: พิมพ์ลิขิต แก้วหานาม
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2022
Subjects: Participatory Process
Participatory Mechanisms
Area Management

description: Journal of Politics and Governance, 12, 1, 168-188
Temperature-driven volume transition in hydrogels: phase--coexistence and interface localization
Creators: name: Cirillo, Emilio N. M.
name: Nardinocchi, Paola
name: Sciarra, Giulio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study volume transition phenomenon in hydrogels within the framework of Flory-Rehner thermodynamic modelling; we show that starting from different models for the Flory parameter different conclusions can be achieved, in terms of admissible coexisting equilibria of the system. In particular, with explicit reference to a one-dimensional problem we establish the ranges of both temperature and traction which allow for the coexistence of a swollen and a shrunk phase. Through consideration of an augmented Flory-Rehner free-energy, which also accounts for the gradient of volume changes, we determine the position of the interface between the coexisting phases, and capture the connection profile between them.
Extra trees in the mixed-mode forest
Creators: name: Mosser, Benoît
name: Belkacem, Kévin
name: Cunha, Margarida S.
name: Deheuvels, Sébastien
name: Matteuzzi, Massimiliano
name: Pinçon, Charly
name: Takata, Masao
name: Vrard, Mathieu
Publisher: name: Zenodo
Year: 2024

description: A large interest of red-giant seismology comes from the ability of dipole modes, which behave has mixed modes, to probe the stellar core of these evolved stars. Unique information has been derived from the mixed-mode pattern, such as evolutionary state, core rotation, mass transfer, and buoyancy glitches. The careful analysis of individual oscillation spectra shows that extra peaks are sometimes present in core-helium burning stars, which do not follow the asymptotic expansion derived from the coupling of a gravity cavity and a pressure cavity. We used the formalism developed to account for complicated cases, as the presence of strong structure glitches or multiple cavities (Cunha et al. 2015, Deheuvels & Belkacem 2018, Pinçon & Takata 2022), to decipher the extra peaks. We could interpret them in terms or supernumerary mixed modes. The determination of the extra asymptotic terms associated with the additional modes makes it possible to better describe the core structure of these stars.
รูปแบบผู้นำสตรีในศตวรรษที่ 21 กับบทบาทการพัฒนาชุมชนของสตรีในจังหวัดร้อยเอ็ด
Creators: name: กัลญา อุปัชฌาย์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2022
Subjects: Leadership
Women
Community Development Role
21st Century

description: Journal of Politics and Governance, 12, 1, 189-203
Additional file 3 of Exploring the contribution of case study research to the evidence base for occupational therapy: a scoping review
Creators: name: McQuaid, Leona
name: Thomson, Katie
name: Bannigan, Katrina
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3. Data extraction instrument (Empirical studies).
Sign conjugacy classes of the symmetric groups
Creators: name: Morotti, Lucia
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: A conjugacy class $C$ of a finite group $G$ is a sign conjugacy class if every irreducible character of $G$ takes value 0, 1 or -1 on $C$. In this paper we classify the sign conjugacy classes of the symmetric groups and thereby verify a conjecture of Olsson.
การเสริมสร้างศักยภาพในการลดความเสี่ยงด้านอุทกภัย ของเทศบาลนครอุบลราชธานี และเทศบาลเมืองวารินชำราบ จังหวัดอุบลราชธานี
Creators: name: เอกราช บุญเริง
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2022
Subjects: Capacity building
Flood disaster risk reduction

description: Journal of Politics and Governance, 12, 1, 204-224
ปัจจัยที่มีอิทธิพลต่อความเป็นอิสระทางการคลังขององค์กรปกครองส่วนท้องถิ่น กรณีศึกษาเทศบาลตำบลในจังหวัดสกลนคร
Creators: name: สุมาพร ชัยศร
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2022
Subjects: Fiscal Operations
Fiscal Autonomy
Local Government
Sakon Nakhon Province

description: Journal of Politics and Governance, 12, 1, 225-242
อิทธิพลของสื่อที่มีต่อการมีส่วนร่วมทางการเมืองของประชาชน ในเทศบาลเมืองเมืองปัก ตำบลเมืองปัก อำเภอปักธงชัย จังหวัดนครราชสีมา
Creators: name: ภัทริกา จุฑางกูร
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2022
Subjects: Media Influences
Media Exposure
Political Participation

description: Journal of Politics and Governance, 12, 1, 243-261
Improving COVID-19 vaccine uptake: a message co-design process for a national mHealth intervention in Colombia
Creators: name: Agudelo-Londoño, Sandra
name: Castro-Barbudo, Daniella
name: Otero Machuca, Jessica
name: Franco-Suarez, Oscar
name: Trujillo, Antonio J.
name: Aya Pastrana, Nathaly
name: Guzman-Tordecilla, Deivis Nicolás
name: López Sánchez, María Camila
name: Rodriguez-Patarroyo, Mariana
name: Rivera-Sánchez, Cristhian Alejandro
name: Vecino-Ortiz, Andres I.
name: Maniar, Vidhi
Publisher: name: Taylor and Francis Group
Year: 2023

description: BACKGROUND: COVID-19 vaccination is a global priority. Latin American countries have some of the highest COVID-19 death rates worldwide with vaccination hampered by a variety of reasons, including mis- and disinformation, vaccine hesitancy, and vaccine supply constraints. Addressing vaccine hesitancy through effective messages has been found to help increase vaccine uptake. Participatory processes could be used to co-design health messages for this purpose. OBJECTIVE: This article describes the methodology used to co-design evidence-based audio messages to be deployed in a cohort of individuals through an interactive voice response (IVR) mobile phone survey intervention, aimed towards increasing vaccination uptake in an adult population in Colombia. METHODS: Participants of the COVID-19 vaccination message co-design process included a sample of the general population of the country, representatives of the funder organisation, and research team members. The co-design process consisted of four phases: (1) formative quantitative and qualitative research, (2) message drafting based on the results of the formative research, (3) message content evaluation, and (4) evaluation of the voices to deliver the audio messages; and was informed by reflexive meetings. RESULTS: Three categories of evidence-based audio messages were co-designed, each corresponding to an arm of the mHealth intervention: (1) factual messages, (2) narrative messages, and (3) mixed messages. An additional fourth arm with no message was proposed for control. The iterative co-design process ended with a total of 14 audio messages recorded to be deployed via the intervention. CONCLUSIONS: Co-developing health messages in response to health emergencies is possible. Adopting more context-relevant, participatory, people-centred, and reflexive multidisciplinary approaches could help develop solutions that are more responsive to the needs of populations and public health priorities. Investing resources in message co-design is deemed to have a greater potential for influencing behaviours and improving health outcomes.
พัฒนาการทางนโยบายการเข้าถึงยาต้านไวรัสเอชไอวีในประเทศไทย และผลกระทบของการเปลี่ยนแปลงนโยบาย: จากยุคจำกัดการเข้าถึงสู่ยุคการรักษาฟรี
Creators: name: พิเชษฐ พิณทอง
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2022
Subjects: Developments of Policy
Antiretroviral Therapy
Impacts of Policy Change

description: Journal of Politics and Governance, 12, 1, 262-285