cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation of vitamin B3, D3 and E as photoprotectors against UVB-induced damages on primary keratinocytes and fibroblasts
Creators: name: Camillo, Lara
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Non-melanoma skin cancer; ultraviolet; keratinocytes; fibroblasts; vitamins; oxidative stress
subject: Non-melanoma skin cancer
subject: ultraviolet
subject: keratinocytes
subject: fibroblasts
subject: vitamins
subject: oxidative stress

description: Non-melanoma skin cancers (NMSCs) are one of the most frequent cancers diagnosed in the elderly Caucasian population. Among several factors that contribute to NMSCs development, ultraviolet (UV) radiations are the main responsible for cancer degeneration. UV can damage cell DNA, trigger ROS production, which oxidize DNA bases causing mutations. Besides, UV inhibit immune response, activate local inflammation, trigger the production of metalloproteinases, and induce cell senescence. Most of the modifications UV-induced contribute to photocarcinogenesis and photoaging. To prevent UV-induced damages especially on high-risk patients, the use of inexpensive chemopreventive molecules with low side effects could help to prevent NMSC development. So, this thesis aims to provide new insights on the role of vitamin B3, D3, and E, in their active forms, as photoprotectors against UVB-induced damages on human primary keratinocytes and fibroblasts. We firstly demonstrated that keratinocytes isolated from field cancerization are more sensible to UV radiations in comparison with normal keratinocytes. However, nicotinamide (NAM) at 25 μM given 24h before irradiation efficiently protected keratinocytes from UVB damages reducing ROS production and DNA damages and blocking the inflammatory response. Then, we proved that NAM and vitamin D3 analog, calcipotriol, can protect human fibroblasts from photoaging by inhibiting ROS release, reducing DNA damages, restoring cell cycle, and decreasing cell senescence. Overall, our results suggest that NAM could be an efficient photoprotector against photocarcinogenesis and photoaging on both keratinocytes and fibroblasts. Moreover, vitamin D3 seems to be protect efficiently fibroblasts from premature aging. Our results might suggest that nicotinamide and vitamin D3 could be used for non-invasive treatment of field cancerization and chronically photoexposed skin areas, in order to prevent NMSC relapse and to reduce demand for surgical treatment.
Evaluierung des Webentwicklungsframeworks eGovWDF im Hinblick auf den Aspekt Validierung und die besonderen Anforderungen im Bereich des eGovernment
Creators: name: Kern, Walter
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: Eingabevalidierung, Evaluation, Barrierefreiheit, Plausibilisierung, Validatoren, Software Engineering, eGovernment
subject: 004 Informatik

description: Wie im Rahmen einer umfangreichen Evaluation gezeigt wurde, erfüllt keines der derzeit erhältlichen Frameworks zur Benutzereingaben-Validierung das sich im Schnittfeld aus Webentwicklung, modernem Software-Engineering und eGovernment ergebende Anforderungsprofil. Auf Basis des genannten Anforderungsprofils wurde im Rahmen der Realisierung eines übergeordneten Rich Client-Webentwicklungsframeworks (eGovWDF – eGovernmental Web Development Framework) für den Einsatz im eGovernment-Bereich ein Validierungsteilframework realisiert, welches auf die vollständige Konformität zu diesen Anforderungen abzielt. Zielsetzung dieser Untersuchung ist nun die Prüfung des Grads der Anforderungserfüllung des eGovWDF-Teilframeworks bezüglich des in der oben genannten Evaluation spezifizierten Anforderungskatalogs.
Evaluierung bedeutender Webapplikations-Entwicklungsframeworks im Hinblick auf die Unterstützung assistiver Komponenten im Kontext der Anforderungen im Bereich eGovernment
Creators: name: Kern, Walter
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: Web 2.0, Webentwicklungsframework, Assistive Technologien, eGovernment
subject: 004 Informatik

description: Wie mehrere kürzlich erschienene wissenschaftliche Publikationen zeigen, existiert eine Vielzahl an Problemen im Schnittfeld der Anforderungen aus Web 2.0-Technologien und Barrierefreiheit. Assistive Technologien können helfen, Defizite bezüglich der Barrierefreiheit von Webanwendungen zu kompensieren und darüber hinausgehende Unterstützung anbieten. Sie erfordern jedoch oft die Installation spezieller, gegebenenfalls kostenpflichtiger Software, die nicht überall vorliegt (z.B. Internet Cafes) und zudem in der Regel nur mit bestimmten Browsern funktioniert. Ferner ist das Funktionieren dieser Technologien abhängig von der Gestaltung und Entwicklung der jeweiligen Webanwendung. All diese Gründe sprechen für die Kapselung assistiver Technologien in Form wiederverwendbarer Komponenten, wodurch Browser- und Rechnerunabhängigkeit und optimale Anwendungsunterstützung erreicht werden kann. Vor Konzeption eines entsprechenden Framework-basierten Ansatzes soll daher im Rahmen dieser Arbeit eine Untersuchung der bedeutendsten und vielversprechendsten, am Markt erhältlichen, Produkte im Webentwicklungsumfeld erfolgen.
Magnetic nanoparticles as nanocarriers and immune modulators for cancer targeted therapy
Creators: name: D'Urso, Annarita
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Cancer; Nanomedicine; macrophages
subject: Cancer
subject: Nanomedicine
subject: macrophages

description: Superparamagnetic iron oxide nanoparticles (SPIONs) and in general magnetic nanoparticles (MNPs) have attracted great interest in the cancer therapy as nanocarriers. SPIONs can be multifunctionalized and manipulated by an external gradient magnetic field (GMF) and an alternating magnetic field (AMF), mediating targeting of different classes of biologically active molecules (chemotherapeutics, antibodies, nucleic acids) and hyperthermia, respectively. SPIONs can also be used not only to target cancer cells, but also the tumor microenvironment (TME), by modulating the activities of the infiltrating host 's cells residing there to restore an anti-tumor response. Indeed, tumor-associated macrophages (TAMs) are the major cell population in the TME and play a prominent role in favoring tumor progression, displaying an M2 phenotype. Macrophages are highly plastic cells, which can acquire different phenotypes according to the microenvironmental stimuli they receive, and can be polarized towards two extreme phenotypes, the classically-activated M1 pro-inflammatory one and the alternatively-activated M2 antiinflammatory and pro-tumor one. TAMs display an irregular unfolded protein response (UPR) in their endoplasmic reticulum (ER) to endure the surrounding environment stress and ensure the protumor activity. Recent studies have suggested that the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) arm of the UPR is uniquely upregulated in TAMs to contribute to the metabolic adaptation necessary to support tumor growth; while other studies have shown that the arm inositol-Requiring Protein 1 (IRE-1) induces the macrophage polarization towards proinflammatory phenotype (M1) by activating the XBP1 protein. In this contest, the re-education of TAMs from the M2 immunosuppressive to the M1 tumoricidal phenotype by modulating UPR with nanotechnology represents an alternative and effective anti-cancer strategy.
5-dimensional braneworld with gravitating Nambu-Goto matching conditions
Creators: name: Kofinas, Georgios
name: Zarikas, Vasilios
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We continue the investigation of a recent proposal on alternative matching conditions for self-gravitating defects which generalize the standard matching conditions. The reasoning for this study is the need for consistency of the various codimension defects and the existence of a meaningful equation of motion at the probe limit, things that seem to lack from the standard approach. These matching conditions arise by varying the brane-bulk action with respect to the brane embedding fields (and not with respect to the bulk metric at the brane position) in a way that takes into account the gravitational back-reaction of the brane to the bulk. They always possess a Nambu-Goto probe limit and any codimension defect is seemingly consistent for any second order bulk gravity theory. Here, we consider in detail the case of a codimension-1 brane in five-dimensional Einstein gravity, derive the generic alternative junction conditions and find the Z_{2}-symmetric braneworld cosmology, as well as its bulk extension. Compared to the standard braneworld cosmology, the new one has an extra integration constant which accounts for the today matter and dark energy contents, therefore, there is more freedom for accommodating the observed cosmic features. One branch of the solution possesses the asymptotic linearized LFRW regime. We have constrained the parameters so that to have a recent passage from a long deceleration era to a small today acceleration epoch and we have computed the age of the universe, consistent with current data, and the time-varying dark energy equation of state. For a range of the parameters it is possible for the presented cosmology to provide a large acceleration in the high energy regime.
description: 23 pages, 2 figures. Version to appear in Ann. Phys. arXiv admin note: substantial text overlap with arXiv:1309.0674
title: На пути к архетипу матери: «Генеральная линия» С. Эйзенштейна и "Земля" А. Довженко
Creators: name: Günther, Hans
Publisher: name: Fachinformationsdienst Slavistik
Year: 2006
Subjects: subject: Ėjzenštejn, Sergej M.
subject: Dovženko, Oleksandr Petrovyč
subject: UdSSR
subject: Filmanalyse
subject: Sublimierung
subject: Große Mutter
subject: Mythos
subject: 491.8

description: In dem Beitrag wurden die Filme „Die Generalinie“ von Eisenstein und „Erde“ von Dovzhenko im Kontext der stalinistischen Mythologie und in Bezug auf Mutterarchetyp untersucht.
description: Советская власть и медиа, p. 542
Hyperbolic entire functions with bounded Fatou components
Creators: name: Bergweiler, Walter
name: Fagella, Núria
name: Rempe-Gillen, Lasse
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: We show that an invariant Fatou component of a hyperbolic transcendental entire function is a bounded Jordan domain (in fact, a quasidisc) if and only if it contains only finitely many critical points and no asymptotic curves. We use this theorem to prove criteria for the boundedness of Fatou components and local connectivity of Julia sets for hyperbolic entire functions, and give examples that demonstrate that our results are optimal. A particularly strong dichotomy is obtained in the case of a function with precisely two critical values.
description: 27 pages, 5 figures. To appear in Commentarii Mathematici Helvetici. V2: Final accepted manuscript (general revision from V1 throughout)
ANTIHYPERTENSIVE THERAPY IN ELDERLY PATIENTS WITH CHRONIC KIDNEY DISEASE
Creators: name: Mirzaeva, G.P.
name: Jabbarov, O.O.
Publisher: name: Zenodo
Year: 2024

description: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), which have nephroprotective effects, are first-line drugs (FL) for treatment of arterial hypertension (AH) in patients with chronic kidney disease (CKD). However, these groups of drugs have a number of contraindications, certain adverse drug reactions, unwanted drug interactions and therefore cannot be prescribed in all AH patients with CKD. Therefore, real clinical practice studies are needed to assess the real frequency of nephroprotective drugs prescription, especially in the elderly.
title: Interaction of model peptides with the peptidyl-prolyl cis/trans isomerases SurA and PpiD
Creators: name: Stymest, Krista Helen
Publisher: name: University of Kent
Year: 2022

description: Over the last 30 years there has been deep interest into the folding of proteins and the mechanisms in which they fold. One of the rate limiting steps of protein folding has been shown to be the cis/trans isomerisation of proline residues, which is catalysed by a range of peptidyl prolyl cis/trans isomerases (PPIases). In the periplasmic space of E.coli and other gram-negative bacteria two PPIases, SurA and PpiD, have been identified, which show high sequence similarity to the catalytic domain of the small PPIase parvulin. This observation raises the question about the biological significance of two apparently similar enzymes being present in the same cellular compartment: Do they interact with different substrates or do they catalyse different reactions? SurA has recently shown to be an important function in the formation of outer membrane porins and the pilus. Recent developments have revealed the crystallographic structure of SurA, indicating a possible region that could act as a binding cleft which corresponds to an area that has been shown to bind peptides. The substrate binding motif of PpiD has not been characterised so far and no biochemical data have been available on how this folding catalyst recognizes and interacts with substrates. To characterise the interaction between model peptides and the periplasmic PPIases PpiD and SurA from E.coli, a chemical cross-linking strategy was employed that has been used previously to elucidate the interaction of substrates with PDI. It was found that PpiD interacted with a range of model peptides independent of whether they contained proline residues or not. It was further demonstrate here that PpiD and SurA could interact with similar amino acids in a specific model peptide and therefore have overlapping substrate recognition motifs. However, the binding motif of PpiD is less specific than the one of SurA, indicating that the two PPIases might interact with different substrates, which was confirmed by in vivo crosslinking. We therefore propose that although PpiD and SurA have overlapping substrate recognition motifs they fulfil different functions in the cell. Molecular modeling coupled with mutagenesis has highlighted residues within SurA that are significant for the overall structure of the protein and subsequently the binding ability. This study has also shown that the N-terminal domain of SurA alone is sufficient for the binding xx Abstract of peptides and does not require the C-terminal domain for binding but does require the C-terminal domain for stability.
Mechanochemistry of fluoride solids: from mechanical activation to mechanically stimulated synthesis
Creators: name: Scholz, Gudrun
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: Mechanical activation
subject: Mechanochemical synthesis
subject: Solid fluorides
subject: 540 Chemie und zugeordnete Wissenschaften

description: This lecture text is focused on the comparatively young field of mechanochemistry of fluoride solids, considering both their mechanical activation and their mechanochemical synthesis. Beside a literature survey, the mechanochemical synthesis of binary fluorides MF2, MF3, of complex fluorides MMgF4, of solid solutions Ma xMb 1−xF2 or M1− xLnxF2+x (Ln: Y, Eu) and of fluorine-containing coordination polymers is presented. Owing to their interesting potential applications in the field of fluoride ion conductivity or luminescence properties when doped, most of the given examples are alkaline earth metal compounds. A short historical survey, remarks on peculiarities and consequences of mechanical activation as well as the necessary technical equipment for mechanochemical reactions precede the section.
Convergence Time for Unbiased Quantized Consensus Over Static and Dynamic Networks
Creators: name: Etesami, Seyed Rasoul
name: Basar, Tamer
Publisher: name: arXiv
Year: 2014
Subjects: subject: Systems and Control (eess.SY)
subject: Social and Information Networks (cs.SI)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: In this paper, the question of expected time to convergence is addressed for unbiased quantized consensus on undirected connected graphs, and some strong results are obtained. The paper first provides a tight expression for the expected convergence time of the unbiased quantized consensus over general but fixed networks. It is shown that the maximum expected convergence time lies within a constant factor of the maximum hitting time of an appropriate lazy random walk, using the theory of harmonic functions for reversible Markov chains. Following this, and using electric resistance analogy of the reversible Markov chains, the paper provides a tight upper bound for the expected convergence time to consensus based on the parameters of the network. Moreover, the paper identifies a precise order of the maximum expected convergence time for some simple graphs such as line graph and cycle. Finally, the results are extended to bound the expected convergence time of the underlying dynamics in time-varying networks. Modeling such dynamics as the evolution of a time inhomogeneous Markov chain, the paper derives a tight upper bound for expected convergence time of the dynamics using the spectral representation of the networks. This upper bound is significantly better than earlier results for the quantized consensus problem over time-varying graphs.
description: The paper is accepted in IEEE Transactions on Automatic Control and will appear soon
Fuel cell electrodes from organometallic platinum precursors: an easy atmospheric plasma approach
Creators: name: DUFOUR, Thierry
name: Merche, Delphine
name: Baneton, Joffrey
name: Caldarella, Giueseppe
name: Debaille, Vincianne
name: Job, Nathalie
name: Reniers, François
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 510602
subject: Plasma physics; fusion plasmas; electrical discharges

description: An organometallic powder (platinum (II) acetylacetonate) is decomposed in the post-discharge of an atmospheric RF plasma torch to deposit Pt nanoparticles on carbon black supports. The resulting nanohybrid materials are characterized by FEG-SEM and XPS techniques to highlight their high content in Pt, their oxidation degree, and the dispersion of the Pt nanoparticles on the substrate. ICP-MS and electrochemical characterizations in a single fuel cell (cyclic voltammetry, dynamic polarization curves) are also performed on electrodes realized by treating the powder mixture overlaid on gas diffusion layers. The comparison of the catalytic activity and the Pt loading with commercially available electrodes shows the great potential of this simple innovative, fast, and robust deposition method.
La reciprocità dei soggetti come principio  etico-politico.  Per una ermeneutica della com-passione
Creators: name: Jervolino, Domenico
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: La reciprocità dei soggetti come principio etico-politico. La sola enunciazione di questo tema suscita difficoltà e imbarazzo. È possibile usare con disinvoltura termini come «soggetto», «principio», «etica», «politica», ignorando il cumulo dei problemi e di interrogativi che essi comportano? Eppure non possiamo fare a meno di correre il rischio insito nell’uso di questi termini, sapendo che lo sforzo per chiarirli non ci mette al riparo dall’ambiguità e dal fraintendimento. Ma si tratta di un “bel rischio” che è necessario correre.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Daten teilen in der Industrie? – Erfahrungen beim Aufbau einer Datenaustauschplattform und Metadata Schema für die KI-Forschung in der Prozessindustrie
Creators: name: Sherpa, Lincoln
name: Müller-Pfefferkorn, Ralph
Publisher: name: Zenodo
Year: 2022
Subjects: SaxFDM-Tagung

description: Die Effizienz und Produktivität der Herstellung chemischer Stoffe in Chemiefabriken hängt wesentlich von optimierten Produktions­prozessen ab. Im Projekt KEEN (KI-Inkubator-Labore in der Pro­zessindustrie) arbeiten zwanzig Partner aus der Prozessindustrie und aus Forschungseinrichtungen zusammen, um mit Hilfe von Methoden der Künstlichen Intelligenz diese Prozesse entlang des gesamten Produktlebenszyklus zu verbessern. Grundlage der Methodenentwicklung und -anwendung sind dabei Messdaten aus dem Produktionsprozess und der Forschung. Um die Daten bes­ser miteinander teilen und nach-nutzen zu können, ist der Aufbau einer Datenaustauschplattform Teil des Projektes. Die Plattform ermöglicht es, die Datensätze nicht nur manuell, sondern auch automatisiert abzulegen und für die Verarbeitung abzurufen. In­tegriert sind ein neues, einheitliches Metadatenschema für die Prozessindustrie sowie Methoden zur Qualitätssicherung, um die strukturierte Beschreibung und das Finden der Daten zu deutlich zu verbessern. Im Vortrag wollen wir zeigen, wie es möglich ist, inhaltliche, methodische und technische Aspekte des Datenmana­gements in enger Zusammenarbeit in einer Anwendungsdisziplin zu entwickeln und umzusetzen.
Ring-cleavage of Phthalidisoquinoline Alkaloids by Ethyl Chloroformate
Creators: name: Angerer, S. von
name: Angerer, E. von
name: Ambros, R.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 540 Chemie

description: Degradation of (-)-α-narcotine (5), (-)-ß-narcotine (6), and (-)-ß-hydrastine (7) with ethyl chloroformate (ECF) affords the chloro-urethans 9 and 18, respectively. Diastereomer 9-1 is easily hydrolyzed to the hydroxy-urethan 10, whilst 18 is converted to the methoxy-analogue 19. The stilbene lactone 11 is obtained from 9-1 by treatment with DBU, the analogous stilbene 17 arises already when 7 is reacted with ECF. - Hydroxy-urethan 10 - a phenylogous aldol - is split by OH" to aldehyde 13 and to meconine (14). LiAIH4- reduction of 10 yields the stereochemically homogenous triol 15, which is cyclized to diastereomers of the 3-phenyl-isochroman 16 under acidic conditions. Der Abbau von (-)-α-Narkotin (5), (-)-ß-Narkotin (6) und (-)-ß-Hydrastin (7) mit Chlorameisensäureethylester (ECF) führt zu den Chlorurethanen 9 bzw. 18. Das Diastereomer 9-1 reagiert leicht zum Hydroxyurethan 10, 18 zum Methoxy-Analogen 19. Chlorurethan 9-1 bildet mit DBU das Stilbenlacton 11, aus 7 entsteht das analoge Stilben 17 bereits beim ECF-Abbau. - Hydroxyurethan 10 (ein phenyloges Aldol) wird durch Basen zum Aldehyd 13 und Mekonin (14) gespalten. LiAIH4 reduziert 10 zum sterisch einheitlichen Triol 15, das H+-katalysiert zu Diastereomeren des 3-Phenylisochromans 16 zyklisiert wird.
Properties of Kenaf Cellulose Nanofiber (CNF) as Potential Larvicide Nanocarrier and Its Acute Ecotoxicity against Daphnia Magna and Dania rerio
Creators: name: Pengiran, Hazirah
name: Kamaldin, Jahangir
name: Fen, Leo Bey
name: Yusob, Siti Aishah Asmah
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The study investigates nonmodified kenaf cellulose nanofiber (CNF) physicochemical properties, loading capability, and its acute toxicity against Daphnia magna and Dania rerio concerning the dispersion stability behavior of the kenaf CNF as a potential larvicide nanocarrier. The physicochemical properties of kenaf CNF were characterized using field emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, specific surface area and porosity, and zeta potential. The loading capability was assessed using various water volumes, and the acute ecotoxicity was determined following the Organisation for Economic Cooperation and Development test guidelines Test no. 202 and Test no. 203, respectively. Kenaf CNF is a fibrous high aspect ratio nanomaterial comprising a negatively charged hydroxyl group with moderate particle stability and high loading capability. With high dispersion stability in the freshwater environment’s aquatic conditions, kenaf CNF did not cause abnormalities and mortality to the D. rerio and no acute immobilization against D. magna. The kenaf CNF could be a candidate to function as a larvicide nanocarrier with insignificant acute ecotoxicity. The EC50 and LC50 for D. magna and D. rerio were above 100 mg/L and classified as nonhazardous to the aquatic environment according to the Globally Harmonized System (GHS).
La Regione sostenibile. Forme giuridiche del regionalismo alla luce del principio di sostenibilità. Spunti comparativi dalle esperienze italiana, francese e spagnola = La Région durable. Formes juridiques du régionalisme au vu du principe de durabilité. Suggestions comparatives à partir des expériences italienne, française et espagnole
Creators: name: Faval, Cherie
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Regione; Enti territoriali; Sostenibilità; Autonomia; Sostenibilità istituzionale; Regionalismo; Territorializzazione; Governance multlivello
subject: Regione
subject: Enti territoriali
subject: Sostenibilità
subject: Autonomia
subject: Sostenibilità istituzionale
subject: Regionalismo
subject: Territorializzazione
subject: Governance multlivello

description: The thesis aims to deal with a classical theme (regional territorial organisation), in a comparative perspective (comparing the Italian Regione, the French Région and the Spanish Comunidad Autónoma) and adopting a dimension that is widely spread (sustainability). In this sense, the research, on the one hand, traces the reference framework of the whole work, introducing the basic concepts (Region; Regional State), not without having previously contextualised them in the perimeter in which it is (still) relevant to deal with them (the questions relating to territorialization and autonomy). Then, the thesis discusses certain characteristics ('static' and 'dynamic' variables of the 'regional state') which are described as emblematic, insofar as their function is both to provide a representative description of the 'regional state', abstractly considered, and to serve as a parameter of the comparative relationship between concrete regional experiences. On the other hand, the thesis analyses the subject of sustainability, attempting, firstly, to trace the origins of the concept and the processes of its "juridicisation" and "constitutionalisation". Secondly, it asks whether it is possible to propose further interpretations of sustainability that could prove useful for an analysis of institutional nature. This component of the work – a sort of "research within the research" – leads to the identification of a notion of institutional sustainability – and, in particular, of regional institutional sustainability – and of a series of potential indicators of sustainability. On this basis, the identified criterion is proposed as a key to interpret the experiences of 'regionalism', with a view not to give exhaustive and complete answers, but to provide useful elements for a fruitful reflection on the existence or not of conditions of permanent and future sustainability of the regional institution.
On the shortfall risk control -- a refinement of the quantile hedging method
Creators: name: Barski, Michał
Publisher: name: arXiv
Year: 2014
Subjects: subject: Pricing of Securities (q-fin.PR)
subject: Optimization and Control (math.OC)
subject: FOS: Economics and business
subject: FOS: Mathematics
subject: 91B30, 91B24, 91B70

description: The issue of constructing a risk minimizing hedge under an additional almost-surely type constraint on the shortfall profile is examined. Several classical risk minimizing problems are adapted to the new setting and solved. In particular, the bankruptcy threat of optimal strategies appearing in the classical risk minimizing setting is ruled out. The existence and concrete forms of optimal strategies in a general semimartingale market model with the use of conditional statistical tests are proven. The well known quantile hedging method as well as the classical Neyman-Pearson lemma are generalized. Optimal hedging strategies with shortfall constraints in the Black-Scholes and exponential Poisson model are explicitly determined.
description: 24 pages in Statistics & Risk Modeling. ISSN (Online) 2196-7040, ISSN (Print) 2193-1402
El infierno es dejar de amar: la profundidad de la culpa y la altura del perdón
Creators: name: Agís Villaverde, Marcelino
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: Fault is the occasion of forgiveness. The expression “difficult forgiveness” means admitting that it is not easy to forgive but neither is it impossible. Forgiveness is an unfinished task that has a double difficulty: on the one hand, it is difficult to give and receive; on the other hand, it is even difficult to conceive. In light of this, we must frame forgiveness between two poles: the depth of fault and the height of forgiveness. Only love is a phenomenon as strange and as difficult to understand as the generosity behind forgiveness.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Evidence of b-jet quenching in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The production of jets associated to bottom quarks is measured for the first time in PbPb collisions at a center-of-mass energy of 2.76 TeV per nucleon pair. Jet spectra are reported in the transverse momentum (pt) range of 80-250 GeV, and within pseudorapidity abs(eta < 2). The nuclear modification factor (R[AA]) calculated from these spectra shows a strong suppression in the b-jet yield in PbPb collisions relative to the yield observed in pp collisions at the same energy. The suppression persists to the largest values of pt studied, and is centrality dependent. The R[AA] is about 0.4 in the most central events, similar to previous observations for inclusive jets. This implies that jet quenching does not have a strong dependence on parton mass and flavor in the jet pt range studied.
description: Replaced with published version. Added journal reference and DOI
Etica della traduzione per un’Europa Plurale
Creators: name: Brezzi, Francesca
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: After a brief analysis of the early themes of Jervolino, the essay analyzes the ethical value of translation, a value that, following Ricoeur, can constitute a common ethos that plural Europe needs. The translators assume the function of cultural mediators, in an authentic and original sense, so as to live in the other language, as invited guests, adapting as much as possible the resources of one and the other terminology. “Linguistic hospitality” represents this ethos of translation on the cultural and spiritual level. From here also a re-interpretation of the myth of Babel.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Sufficient Bigness Criterion for Differences of Two Nef Classes
Creators: name: Popovici, Dan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: We prove the qualitative part of Demailly's conjecture on transcendental Morse inequalities for differences of two nef classes satisfying a numerical relative positivity condition on an arbitrary compact Kähler (and even more general) manifold. The result improves on an earlier one by J. Xiao whose constant $4n$ featuring in the hypothesis is now replaced by the optimal and natural $n$. Our method follows arguments by Chiose as subsequently used by Xiao up to the point where we introduce a new way of handling the estimates in a certain Monge-Ampère equation. This result is needed to extend to the Kähler case and to transcendental classes the Boucksom-Demailly-Paun-Peternell cone duality theorem if one is to follow these authors' method and was conjectured by them.
description: 7 pages; to appear in Mathematische Annalen; the title has been changed and the abstract reformulated at the referee's suggestion
Analysis on the Yarn and Fabric Characteristics of Chiengora Fibers from Hairs of Lhasa Apso Breed and Its Blends in Comparison with Wool and Its Blends. Part II – Fabric Characteristics
Creators: name: Ramamoorthy, Surjit
name: Ramadoss, Murugan
name: Thangavelu, Karthik
name: Jagannathan, Vishnu Vardhini Kalapatti
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: The chiengora yarns and woolen yarns along with polyester and acrylic are knitted into fabrics with 2 × 2 rib structures in 16 blend proportions. The properties of the chiengora fabrics and its blends are ascertained and compared with the properties of developed knitted wool fabrics and its blends. It is observed that the bursting strength of fabrics decreases with increase in chiengora content similar to woolen fabrics. The air permeability, wickability, and water vapor permeability are found to be lesser for 100% chiengora fabrics similar to the woolen fabrics. The chiengora fabrics possess better thermal insulation property. The 100% lhasa apso fabric has a thermal insulation value (TIV) of 0.606 clo, which is 38% more than the 100% wool fabric, which has 0.373 clo, thereby confirming that these fabrics can be used for thermal wears like sweaters. The presence of scales and thermal properties indicates better thermal insulation properties for these chiengora fiber fabrics. The 75/25 lhasa apso polyester fabrics can be considered as the better blend proportion than other produced fabrics due to their better yarn properties, comfort properties, and higher TIV than wool. The end use for all the produced chiengora blended fabrics is given based on the TIV.
Brief History of Northwesterns Dispensaries and Outpatient Clinics: Part 2, 1926-1975
Creators: name: Sims, Ronald H
Publisher: name: Galter Health Science Library & Learning Center
Year: 2016

description: The information in this article (and its Part 1) was part of the exhibit, Photographing Pediatrics, which began mid-June 2011 in Dollie's Corner, on Level 2 of the Galter Health Sciences Library, a collaboration of Ron Sims, Dr. Paula Summerly, post-doc in Medical Humanities and Sue Sacharski, Northwestern Memorial Hospital Archivist. The exhibit included a pictorial history of the dispensary and clinics at Northwestern. (Another version of this two-part article was published in Northwestern Medicine magazine's history blog, Sept. 2014)
Valorization and Evaluation of Terminalia Ivorensis Fibrous Waste for Its Environmental Sequestration Potential for Industrial Anionic Dyes in Aqua System
Creators: name: Olatunde, Abimbola M.
name: Omorogie, Martins O.
name: Agbadaola, Michael T.
name: Adesina, Oreoluwa O.
name: Adeleye, Elizabeth O.
name: Babalola, Jonathan O.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: This research depicts the pragmatic sequestration capacity of ubiquitous Terminalia ivorensis tree bark (TITB) on toxic anionic dyes (congo red (CR), methyl orange (MO), chlorophenol red (CPR), and Eosin Y (EY)) from aqua system. Surface characterization of TITB by bulk density, Boehm titration, pH of point of zero charge (pHPZC), field emission-scanning electron microscopy (FE-SEM) and Fourier transform infrared (FTIR) spectroscopy revealed that TITB comprise rough intertwined texture with some functional moieties which adsorbed the industrial dyes. The adsorption capacities (qe) of MO, CR, and EY were maximum at pH 2.0 (qe= 84.59, 92.67 and 92 mg.g−1 respectively) while that of CPR was maximum at pH 6.0 (qe= 99.05 mg.g−1). Langmuir monolayer coverage capacity (qmax) of TITB was obtained for the adsorption of EY, which was 142.45 mg.g−1. Adsorption kinetics conformed to pseudo-second order kinetic model with a rate constant, k2 ≤ 0.9702 min−1. The change in Gibbs free energy (ΔG°) for the adsorption process was found to be negative showing that the maximum adsorption was spontaneous at operational temperatures for all dyes. Enthalpy and entropy change (∆H° and ∆S°) were positive for CR, MB, and EY describing endothermic form and increased disorderliness between the adsorbent-dye interface.
Beyond Q-Resolution and Prenex Form: A Proof System for Quantified Constraint Satisfaction
Creators: name: Chen, Hubie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Artificial Intelligence (cs.AI)
subject: Computational Complexity (cs.CC)
subject: FOS: Computer and information sciences

description: We consider the quantified constraint satisfaction problem (QCSP) which is to decide, given a structure and a first-order sentence (not assumed here to be in prenex form) built from conjunction and quantification, whether or not the sentence is true on the structure. We present a proof system for certifying the falsity of QCSP instances and develop its basic theory; for instance, we provide an algorithmic interpretation of its behavior. Our proof system places the established Q-resolution proof system in a broader context, and also allows us to derive QCSP tractability results.
Acute peritonitis inaugurating Crohn's disease with spontaneous perforation in the peritoneal cavity_CARE_checklist.pdf
Creators: name: KHEFACHA, Fahd
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 429999
subject: Other health sciences not elsewhere classified

description: The manuscript is about a rare case of a Crohn's disease which was inaugurated by an acute peritonitis. Such inauguration is very rare, leading us to publish this rare case report. All CARE items were checked.
Phenotypic characterization of immune cell populations in homeostatic and FVIII-challenged severe HA mice
Creators: name: Kalandadze, Vakhtang
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Hemophilia A; Factor VIII; T cells
subject: Hemophilia A
subject: Factor VIII
subject: T cells

description: Development of FVIII-neutralizing antibodies (inhibitors) is one of the main complications occurring in 30% of severe hemophilia A (HA) patients undergoing replacement therapy. Both lack of central tolerance, due to the congenital absence of FVIII, and the presence of danger signals are factors involved in inhibitors development, which is definitely related to the immune cells activation. Since recent studies have been proposing new extra-coagulative roles for FVIII in the immuno-hematological biology and have shown the presence of increased levels of several inflammatory cytokines in untreated HA patients, we sought to investigate the effect of FVIII absence on the immune cell populations before and after challenge with a specific (FVIII) or general (OVA) immunological challenge. We also sought to investigate the capability of naïve CD4 T cells to differentiate into T regulatory cells. We employed a mouse model of severe HA and we did not observe any significative change in number and percentage of primary immune populations (e.g. T and B cells) and in the quantitative humoral response against FVIII or OVA when compare to control age- and treatment-matched animals. On the other hand, HA mice challenged with both antigens showed higher conversion of naïve to memory T cells. Interestingly, these differences were detected only when the immunological challenge included an adjuvant while it was absent when FVIII was injected intravenously without any supplemental stimulus, as it happens in the normal therapeutic regimen. Overall, the results obtained in this thesis suggest that immunogenic versus tolerogenic response to FVIII in HA patients could depend on the reciprocal interactions of extrinsic and intrinsic factors among which the pro-inflammatory microenvironment determined by the recurrent microbleedings should be taken in consideration.
Dithranol, Glucose-6-phosphate Dehydrogenase Inhibition and Active Oxygen Species
Creators: name: Müller, K.
name: Seidel, M.
name: Braun, C.
name: Ziereis, K.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: Anthralin, in vitro studies • Antipsoriatic drugs • CAS 480-22-8 • Dithranol • Free radicals • Glucose-6-phosphate dehydrogenase, inhibition
subject: 540 Chemie

description: Inhibition of glucose-6-phosphate dehydrogenase (G6- PDH) by dithranpl (anthralin, CAS 480-22-8) has been studied in the presence of catalase, superoxide dismutase (SOD) and various scavengers of active oxygen species. Most scavengers were found to be either inhibitors of G6- PDH by themselves or simply without effect. The combined addition of catalase and SOD as well as the heatdenatured enzymes and the oxygen radical scavengers atocopherol and salicylic acid markedly reduced the inhibitory effect of dithranol. The direct exposure of G6-PDH to active oxygen species led to different results. When liberated from a water-soluble naphthalene endoperoxide, singlet oxygen was without effect whereas photosensitization with methylene blue resulted in a total loss of enzyme activity. Experiments under anaerobic conditions revealed that this inhibition was accomplished by the triplet state of the sensitizer. Superoxide anion radical was highly effective at concentrations corresponding to the amount of that produced by a 10 nmol/l dithranol solution. In contrast, hydroxyl, alkylperoxyl and alkoxyl radicals were all less efficient. H202 and alkylhydroperoxides did not alter the enzyme activity. The results suggest that O2 is the potent species towards G6-PDH, if dithranol acts through formation of active oxygen species. Glucose-6-phosphat-Dehydrogenase (G6-PDH)-Hemmung durch Dithranol (Anthralin, CAS 480-22-8) wurde in Gegenwart von Catalase, Superoxid-Dismutase (SOD) und verschiedenen Fängern für aktive Sauerstoffspezies untersucht. Die meisten Fänger waren entweder selbst Hemmstoffe der G6-PDH oder wirkungslos. Sowohl die kombinierte Zugabe von Catalase und SOD als auch die denaturierten Enzyme, ebenso die Sauerstoffradikalfänger a-Tocopherol und Salicylsäure zeigten eine deutliche Reduzierung der durch Dithranol verursachten Hemmefi fekte. Die direkte Einwirkung von aktiven Sauerstoffspezies auf G6-PDH führte zu unterschiedlichen Resultaten. Freisetzung von Singulett-Sauerstoff aus einem wasserlöslichen Endoperoxid war ohne Effekt, hingegen führte die Photosensibilisierung mit Methylenblau zum vollständigen Verlust der Enzymaktivität. Experimente unter anaeroben Bedingungen zeigten jedoch, daß diese Hemmung durch den Triplett-Zustand des Sensibilisators verursacht wurde. Superoxid-Anion-Radikal erwies sich in Konzentrationen, die von einer 10 jumol/l Dithranol-Lösung produziert werden, als hochwirksam. Hydroxyl-, Alkylperoxyl- und Alkoxyl-Radikale waren hingegen weniger wirksam. H202 und Alkylhydroperoxide führten zu keiner Beeinträchtigung der Enzymaktivität. Die Resultate deuten darauf hin, daß O2 die potente Spezies der G6-PDH-Hemmung durch Dithranol ist, wenn diese über die aktiven Sauerstoffspezies erfolgt
Distributed Optimal Power Flow Algorithm for Balanced Radial Distribution Networks
Creators: name: Peng, Qiuyu
name: Low, Steven H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: The optimal power flow (OPF) problem is fundamental in power system operations and planning. Large-scale renewable penetration in distribution networks calls for real-time feedback control, and hence the need for fast and distributed solutions for OPF. This is difficult because OPF is nonconvex and Kirchhoff's laws are global. In this paper we propose a solution for balanced radial distribution networks. It exploits recent results that suggest solving for a globally optimal solution of OPF over a radial network through the second-order cone program (SOCP) relaxation. Our distributed algorithm is based on alternating direction method of multiplier (ADMM), but unlike standard ADMM algorithms that often require iteratively solving optimization subproblems in each ADMM iteration, our decomposition allows us to derive closed form solutions for these subproblems, greatly speeding up each ADMM iteration. We present simulations on a real-world 2,065-bus distribution network to illustrate the scalability and optimality of the proposed algorithm.
Ascesi del pensiero ed apertura all’alterità  nella riflessione filosofica di Domenico Jervolino
Creators: name: Brugiatelli, Vereno
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: In this study I will take into consideration Domenico Jervolino’s work focusing on two fundamental moments in philosophical reflection: the opening up of philosophy towards otherness and asceticism of thought. I will highlight the fact that the first moment is based on and fostered by the second and that both form part of a philosophical activity which aims to pursue the practical ends of dignity, solidarity, hospitality and human liberation.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
The influence of power and frequency on the filamentary behavior of a flowing DBD - Application to the splitting of CO2
Creators: name: DUFOUR, Thierry
name: Ozkan, Alp
name: Silva, Tiago
name: Britun, Nikolay
name: Snyders, Rony
name: Bogaerts, Annemie
name: Reniers, François
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 510602
subject: Plasma physics; fusion plasmas; electrical discharges

description: In this experimental study, a flowing dielectric barrier discharge operating at atmospheric pressure is used for the splitting of CO2 into O2 and CO. The influence of the applied frequency and plasma power on the microdischarge properties is investigated to understand their role on the CO2 conversion. Electrical measurements are carried out to explain the conversion trends and to characterize the microdischarges through their number, their lifetime, their intensity and the induced electrical charge. Their influence on the gas and electrode temperatures is also evidenced through optical emission spectroscopy and infrared imaging. It is shown that, in our configuration, the conversion depends mostly on the charge delivered in the plasma and not on the effective plasma voltage when the applied power is modified. Similarly, at constant total current, a better conversion is observed at low frequencies, where a less filamentary discharge regime with a higher effective plasma voltage than that at a higher frequency is obtained.