cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
[PDF/Kindle] All Fours by Miranda July
Creators: name: Jackson
Publisher: name: Zenodo
Year: 2024

description: All Fours by Miranda July

 

 

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All Fours

Miranda July

Page: 336

Format: pdf, ePub, mobi, fb2

ISBN: 9780593190265

Publisher: Penguin Publishing Group

 

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All Fours Trini Card Game - Apps on Google Play Play All Fours - Trinidad and Tobago's favorite Card Game by CardsClan.com. All Fours: A Novel: July, Miranda - Books All Fours Online 2 - Apps on Google Play About this game. arrow_forward. If you're an All Fours lover, your favourite game has returned to smart phones! Play All Fours with real players online; call  All four All four · All fours (human position) · All fours (card game), 17th-century game still played today that gave rise to the All Fours family · A concept in  All Fours: Miranda July's new novel might derail your life May 16, 2024 — All Fours on XX (Twitter)https://twitter.com/search/All+Fours 21 Synonyms & Antonyms for ON ALL FOURS on all fours · crawling · groveling · hobbling · inching · quailing · shambling · shuffling · skulking · slinking · slithering · sneaking · squirming · worming  on all fours | Wex | US Law | LII / Legal Information Institute Primary tabs. “On all fours” is a metaphor used by legal practitioners to describe a previous case with facts that are substantially similar to the case at
Supplementary material from Asymmetric drop coalescence launches fungal ballistospores with directionality
Creators: name: Fangjie Liu
name: Chavez, Roger L.
name: S. N. Patek
name: Pringle, Anne
name: Feng, James J.
name: Chen, Chuan-Hua
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Thousands of fungal species use surface energy to power the launch of their ballistospores. The surface energy is released when a spherical Buller's drop at the spore's hilar appendix merges with a flattened drop on the adaxial side of the spore. The launching mechanism is primarily understood in terms of energetic models, and crucial features such as launching directionality are unexplained. Integrating experiments and simulations, we advance a mechanistic model based on the capillary–inertial coalescence between the Buller's drop and the adaxial drop, a pair that is asymmetric in size, shape and relative position. The asymmetric coalescence is surprisingly effective and robust, producing a launching momentum governed by the Buller's drop and a launching direction along the adaxial plane of the spore. These key functions of momentum generation and directional control are elucidated by numerical simulations, demonstrated on spore-mimicking particles, and corroborated by published ballistospore kinematics. Our work places the morpho-logical and kinematic diversity of ballistospores into a general mechanical framework, and points to a generic catapulting mechanism of colloidal particles with implications for both biology and engineering.
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
Creators: name: Kim, Jaehyoung
name: Peterson, Daniel A.
name: Zhang, Min
name: Moriyama, Etsuko N.
name: Legge, Ryan
name: Kelly, Scott A.
name: Walter, Jens
name: Hua, Kunjie
name: Kachman, Stephen D.
name: Low, Soo Jen
name: Pomp, Daniel
name: Benson, Andrew K.
name: Ma, Fangrui
name: Nehrenberg, Derrick
name: Oh, Phaik Lyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions of dominant microbial groups are tremendously varied. Although external and stochastic factors clearly contribute to the individuality of the microbiota, the fundamental principles dictating how environmental factors and host genetic factors combine to shape this complex ecosystem are largely unknown and require systematic study. Here we examined factors that affect microbiota composition in a large (n = 645) mouse advanced intercross line originating from a cross between C57BL/6J and an ICR-derived outbred line (HR). Quantitative pyrosequencing of the microbiota defined a core measurable microbiota (CMM) of 64 conserved taxonomic groups that varied quantitatively across most animals in the population. Although some of this variation can be explained by litter and cohort effects, individual host genotype had a measurable contribution. Testing of the CMM abundances for cosegregation with 530 fully informative SNP markers identified 18 host quantitative trait loci (QTL) that show significant or suggestive genome-wide linkage with relative abundances of specific microbial taxa. These QTL affect microbiota composition in three ways; some loci control individual microbial species, some control groups of related taxa, and some have putative pleiotropic effects on groups of distantly related organisms. These data provide clear evidence for the importance of host genetic control in shaping individual microbiome diversity in mammals, a key step toward understanding the factors that govern the assemblages of gut microbiota associated with complex diseases.
title: From Transition To Transitioning: An Anthropological Study of Female To Male Transsexuality
Creators: name: Gonzalez-Polledo Bermudez, Elena
Publisher: name: Goldsmiths, University of London
Year: 2010

description: This thesis explores Female To Male processes of transition through ethnographic and qualitative data gathered during fieldwork in the trans community in London, and through critical engagement with existing discourses of trans sexuality. Despite the greater visibility of Male to Female transsexuality in academic texts and popular culture, FTM transition remains largely under theorised. This research is an anthropological contribution to this field, as well as to current developments in social anthropology and the anthropology of gender. Transition has been traditionally theorised through the sex/gender distinction, where sex and gender hold different ontological and political values, and it is understood as the passage from 'female' to 'male' in terms of the intersection of a series of biological, psychological, social and legal changes. Even though recent discourses of sexuality have pointed out the limitations of this paradigm, they still reinforce universal models of the relation between sex and gender and abstract categories such as subjectivity, time and experience. However, my informants understood that their transitions were complex and unique, and that their experience of transitioning was not necessarily exclusively about sex/gender. They described their experiences of transition in very different ways, where hormones, surgery and other transitional technologies were not mechanistic agents in their processes, but part of particular assemblages through which change, continuity and time are brought into experience through becoming 'FTM'. Therefore, in this thesis FTM is understood as a particular kind of becoming rather than the passage between static categories. In the first part of the thesis I explore existing ways of conceptualising transsexuality and transition through a series of theoretical, medical and political' coordinates'. I focus on how the emergence of protocols of clinical management of transsexuality were grounded in the distinction between sex and gender, and unpack some of the ways in which this distinction informed the emergence of political discourses of sexuality and sexual formation through which trans people in Britain construct their individual and collective identities. In the second part I explore three subjects privileged by the participants in my primary research: testosterone, narrative and thresholds. I argue that these domains both reproduce categories and the language of linear passage and demand a different analytic approach. Each chapter explicates 'FTM' by exploring different kinds, scales and temporalities of experience, as well as the kinds, scales and temporalities of the relations between them.
The Effect of Structural Equation Modeling on Chatbot Usage: An Investigation of Dialogflow
Creators: name: Nguyen, Vinh T.
name: Nguyen, Chuyen T. H.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: This study aims to understand users' perceptions of using the Dialogflow framework and verify the relationships among service awareness, task-technology fit, output quality, and TAM variables. Generalized Structured Component Analysis was employed to experiment with six hypotheses. Two hundred twenty-seven participants were recruited through the purposive non-random sampling technique. Google Forms was utilized as a medium to develop and distribute survey questionnaires to subjects of interest. The experimental results indicated that perceived ease of use and usefulness had a statistically significant and positive influence on behavioral intention. Awareness of service and output quality was considered reliable predictors of perceived usefulness. Also, perceived task-technology fit positively affected perceived ease of use. The model specification accounted for 50.04% of the total variation. The findings can be leveraged to reinforce TAM in future research in a comparative academic context to validate the hypothesis. Several practitioner recommendations and the study's limitations have been presented.
Splitting CO2 into CO and O2 by a single catalyst
Creators: name: Concepcion, Javier J.
name: Hoertz, Paul G.
name: Kang, Peng
name: Brennaman, M. Kyle
name: Norris, Michael R.
name: Chen, Zuofeng
name: Meyer, Thomas J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The metal complex [(tpy)(Mebim-py)RuII(S)]2+ (tpy = 2,2′ : 6′,2′′-terpyridine; Mebim-py = 3-methyl-1-pyridylbenzimidazol-2-ylidene; S = solvent) is a robust, reactive electrocatalyst toward both water oxidation to oxygen and carbon dioxide reduction to carbon monoxide. Here we describe its use as a single electrocatalyst for CO2 splitting, CO2 → CO + 1/2 O2, in a two-compartment electrochemical cell.
Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity
Creators: name: Messer, William B.
name: Kahle, Kristen M.
name: Pfaff, Jennifer M.
name: De Silva, Aravinda M.
name: Baric, Ralph S.
name: Crowe, James E.
name: De Alwis, Ruklanthi
name: Yount, Boyd L.
name: Huynh, Jeremy P.
name: Smith, Scott A.
name: Sariol, Carlos A.
name: White, Laura J.
name: Doranz, Benjamin J.
name: Royal, Scott R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Dengue virus is the most important arthropod-borne viral disease of humans worldwide, with an estimated 390 million acute infections annually. The best means to control this global health threat is a vaccine, but dengue vaccine development has progressed slowly, partly because the antigenic targets required to stimulate long-term immunity are not well-defined. Here, we show a specific region on the viral surface (the envelope domain I/II hinge) that is the target of protective antibodies after primary human infections. These results are critically important for dengue vaccine design, because we hypothesize that a successful dengue vaccine will stimulate antibodies that target this region. More broadly, this study establishes a template for similar approaches for improving vaccines for influenza, HIV, hepatitis C virus, and other clinically important viral pathogens.
Non-equilibrium pre-thermal states in a two-dimensional photon fluid
Creators: name: Abuzarli, Murad
name: Cherroret, Nicolas
name: Bienaimé, Tom
name: Glorieux, Quentin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Thermalization is the dynamical process by which a many-body system evolves toward a thermal equilibrium state that maximizes its entropy. In certain cases, however, the establishment of thermal equilibrium is significantly slowed down and a phenomenon of pre-thermalization can emerge. It describes the initial relaxation toward a quasi-steady state after a perturbation. While having similar properties to their thermal counterparts, pre-thermal states exhibit a partial memory of initial conditions. Here, we observe the dynamical formation of a pre-thermal state in a non-equilibrium, two-dimensional (2D) fluid of light after an interaction quench. Direct measurements of the fluid's first-order correlation function reveal the spontaneous emergence of long-range algebraic correlations spreading within a light-cone, providing a clear signature of a quasi steady-state strongly similar to a 2D thermal superfluid. Detailed experimental characterization of the algebraic order is presented and a partial memory of the initial conditions is demonstrated, in agreement with recent theoretical predictions. Furthermore, by a controlled increase of the fluid fluctuations, we unveil a cross-over from algebraic to short-range (exponential) correlations, analogous to the celebrated Kosterlitz-Thouless transition observed at thermal equilibrium. These results suggest the existence of non-equilibrium precursors for thermodynamic phase transitions.
Robert Kuok A Memoir by Andrew Tanzer on Audiobook New
Creators: name: Dryden
Publisher: name: Zenodo
Year: 2024

description: Robert Kuok A Memoir by Andrew Tanzer

 

 

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Robert Kuok A Memoir

Andrew Tanzer

Page: 376

Format: pdf, ePub, mobi, fb2

ISBN: 9789814189736

Publisher: John Beaufoy Publishing

 

Free kindle ebook downloads for mac Robert Kuok A Memoir 9789814189736 by Andrew Tanzer

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Robert Kuok A Memoir by Andrew Tanzer Robert Kuok is one of the most highly respected businessmen in Asia. But this legendary Overseas Chinese entrepreneur, commodities trader who made his first milion on the London sugar market, hotelier of the Shangri-la chain, and property mogul has maintained a low profile and seldom shed light in public on his business empire or personal life. That is, until now. In these memoirs, the 94-year-old Kuok tells the remarkable story of how, starting in British Colonial Malaya, he built a multi-industry, multinational business group. In reflecting back on 75 years of conducting business, he offers management insights, discusses strategies and lessons learned, and relates his principles, philosophy, and moral code. Kuok has lived through fascinating and often tumultuous times in Asia – from British colonialism to Japanese military occupation to post-colonial Southeast Asia and the dramatic rise of Asian economies, including, more recently, China. From his front-row seat and as an active participant, this keen, multi-cultural observer tells nearly a century of Asian history through his life and times. Readers interested in business, management, history, politics, culture and sociology will all enjoy Robert Kuok’s unique and remarkable story.
Planar Graphs of Girth at least Five are Square $(Δ+ 2)$-Choosable
Creators: name: Bonamy, Marthe
name: Cranston, Daniel W.
name: Postle, Luke
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We prove a conjecture of Dvořák, Král, Nejedlý, and Škrekovski that planar graphs of girth at least five are square $(Δ+2)$-colorable for large enough $Δ$. In fact, we prove the stronger statement that such graphs are square $(Δ+2)$-choosable and even square $(Δ+2)$-paintable.
description: 22 pages, 7 figures; this version incorporates reviewer feedback: fixed and rewrote proof of Lemma 3.5, expanded Section 4; to appear in J. Combin. Theory Ser. B
Magnetic dipole moments of $B_{(s)}^{(*)}B_{(s)}^{(*)}$ states
Creators: name: Ozdem, U.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We systematically study the magnetic dipole moments of multiquark states. In this study, the magnetic dipole moments of possible $B^- B^{*-}$, $B^0 B^{*-}$, $B^- B^{*0} $, $B^0 B^{*0}$, $B_s^0 B^{*-}$, $B^- B_s^{*0}$, $B_s^{0} B^{*0}$, $B^0 B_s^{*0}$ and $B^0_s B_s^{*0}$ states are extracted using light-cone sum rules. We explore magnetic dipole moments of these states as molecular picture with spin-parity $J^P = 1^+$. The magnetic dipole moments of hadrons include useful information on the distributions of internal charge and magnetization, which can be used to understand their geometrical shapes and quark-gluon organization. The results of the present study along with the spectroscopic parameters may help the future theoretical and experimental research on the characteristics of doubly-bottom tetraquark states.
description: 12 pages, 2 tables and 2 figures
Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography
Creators: name: Oldenburg, Amy L.
name: Wu, Wei Chen
name: Button, Brian
name: Casbas-Hernandez, Patricia
name: Hill, David B.
name: Yang, Changhuei
name: Tracy, Joseph B.
name: Troester, Melissa A.
name: Chhetri, Raghav K.
name: Blackmon, Richard L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Many diseases are characterized by nanostructural changes in connective fibers and soluble proteins, which can indicate or drive disease progression. Noninvasive methods sensitive to nanotopological changes in 3D tissue models can elucidate biophysical changes associated with disease progression. Nanoparticles probe their environment via their diffusion, which is impacted by the size and connectivity of pores into which they freely diffuse. Here, we show that optical coherence tomography provides depth-resolved imaging of gold nanorods (GNRs) to infer local biological nanotopology. We demonstrate the broad potential of this method by sensing changes in diffusion of GNRs in 3D models of mammary ECM and pulmonary mucus.
Complex Supersymmetry in Graphene
Creators: name: Castillo-Celeita, Miguel
name: Contreras-Astorga, Alonso
name: C, David J. Fernández
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This work analyzes monolayer graphene in external electromagnetic fields, which is described by the Dirac equation with minimal coupling. Supersymmetric quantum mechanics allows building new Dirac equations with modified magnetic fields. Here, we will use complex factorization energies and iterate the method in order to arrive at Hermitian graphene Hamiltonians. Finally, we compare these results with the matrix supersymmetric quantum mechanics approach.
Limits to the evolution of assortative mating by female choice under restricted gene flow
Creators: name: Servedio, Maria R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The evolution of assortative mating is a key component of the process of speciation with gene flow. Several recent theoretical studies have pointed out, however, that sexual selection which can result from assortative mating may cause it to plateau at an intermediate level; this is primarily owing to search costs of individuals with extreme phenotypes and to assortative preferences developed by individuals with intermediate phenotypes. I explore the limitations of assortative mating further by analysing a simple model in which these factors have been removed. Specifically, I use a haploid two-population model to ask whether the existence of assortative mating is sufficient to drive the further evolution of assortative mating. I find that a weakening in the effective strength of sexual selection with strong assortment leads to the existence of both a peak level of trait differentiation and the evolution of an intermediate level of assortative mating that will cause that peak. This result is robust to the inclusion of local adaptation and different genetic architecture of the trait. The results imply the existence of fundamental limits to the evolution of assortment via sexual selection in this situation, with which other factors, such as search costs, may interact.
Real-Word Error Correction with Trigrams: Correcting Multiple Errors in a Sentence
Creators: name: Dashti, Seyed MohammadSadegh
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Spelling correction is a fundamental task in Text Mining. In this study, we assess the real-word error correction model proposed by Mays, Damerau and Mercer and describe several drawbacks of the model. We propose a new variation which focuses on detecting and correcting multiple real-word errors in a sentence, by manipulating a Probabilistic Context-Free Grammar (PCFG) to discriminate between items in the search space. We test our approach on the Wall Street Journal corpus and show that it outperforms Hirst and Budanitsky's WordNet-based method and Wilcox-O'Hearn, Hirst, and Budanitsky's fixed windows size method.-O'Hearn, Hirst, and Budanitsky's fixed windows size method.
(3182) Cyril Reginald Stanley Beale
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Variation in growth and instar number in field and laboratory Manduca sexta
Creators: name: Kingsolver, Joel G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The tobacco hornworm Manduca sexta has been an important model system for understanding physiological control of growth, development and metamorphosis of insects for more than half a century. Like all Manduca, M. sexta typically has five larval instars, with developmental commitment to metamorphosis occurring early in the 5th (final) instar. Here we show that M. sexta from a field population in North Carolina (USA) shows substantial intraspecific variation in the number of larval instars when feeding on a modified artificial diet. Individuals with six instars consistently exhibited slower growth rates during early larval development than individuals with five instars. The frequency of individuals with six instars decreased with increased rearing temperature. In contrast, M. sexta from a laboratory colony consistently had five instars, and had more rapid larval growth rates than M. sexta from the field. We identify a threshold body size at the start of the 5th instar that predicts whether an individual will have five (greater than 600 mg) or six instars (less than 600 mg). Variation in field populations in Manduca provides an important resource for understanding physiological control, developmental plasticity and evolution of growth rate, body size and instar number.
Climate variability slows evolutionary responses of Colias butterflies to recent climate change
Creators: name: Buckley, Lauren B.
name: Kingsolver, Joel G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: How does recent climate warming and climate variability alter fitness, phenotypic selection and evolution in natural populations? We combine biophysical, demographic and evolutionary models with recent climate data to address this question for the subalpine and alpine butterfly, Colias meadii, in the southern Rocky Mountains. We focus on predicting patterns of selection and evolution for a key thermoregulatory trait, melanin (solar absorptivity) on the posterior ventral hindwings, which affects patterns of body temperature, flight activity, adult and egg survival, and reproductive success in Colias. Both mean annual summer temperatures and thermal variability within summers have increased during the past 60 years at subalpine and alpine sites. At the subalpine site, predicted directional selection on wing absorptivity has shifted from generally positive (favouring increased wing melanin) to generally negative during the past 60 years, but there is substantial variation among years in the predicted magnitude and direction of selection and the optimal absorptivity. The predicted magnitude of directional selection at the alpine site declined during the past 60 years and varies substantially among years, but selection has generally been positive at this site. Predicted evolutionary responses to mean climate warming at the subalpine site since 1980 is small, because of the variability in selection and asymmetry of the fitness function. At both sites, the predicted effects of adaptive evolution on mean population fitness are much smaller than the fluctuations in mean fitness due to climate variability among years. Our analyses suggest that variation in climate within and among years may strongly limit evolutionary responses of ectotherms to mean climate warming in these habitats.
Experimental Progress on the Emergent Infinite-Layer Ni-Based Superconductors
Creators: name: Zhou, Xiaorong
name: Qin, Peixin
name: Feng, Zexin
name: Yan, Han
name: Wang, Xiaoning
name: Chen, Hongyu
name: Meng, Ziang
name: Liu, Zhiqi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The emergence of the infinite-layer superconducting nickelate thin films marks the Ni age of superconductivity, which has excited a huge surge of studies since the first report in August of 2019. Despite of the tremendous attention drawn from the entire material science community and a large body of theoretical studies, the experimental progress has been relatively slow due to the challenging sample fabrication, which may, in turn, be holding back the fast development of theoretical research. Therefore, a timely and comprehensive review on all the up-to-date experimental progress of the emergent infinite-layer Ni-based superconductors is urgently needed. In this review, we first introduce the history of more than 30-year-long Ni-based superconductivity exploration, then summarize the sample fabrication processes, later present the experimental electrical transport and magnetic properties, and finally come up with several key issues deserving intensive studies. This review is thus expected to be helpful for researchers with diverse research background to readily capture the major progress of this emerging field.
description: 36 pages, 23 figures, a review article published online at Materials Today
The impact of individual nuclear masses on $r$-process abundances
Creators: name: Mumpower, M. R.
name: Surman, R.
name: Fang, D. -L.
name: Beard, M.
name: Moller, P.
name: Kawano, T.
name: Aprahamian, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have performed for the first time a comprehensive study of the sensitivity of $r$-process nucleosynthesis to individual nuclear masses across the chart of nuclides. Using the latest version (2012) of the Finite-Range Droplet Model, we consider mass variations of $\pm0.5$ MeV and propagate each mass change to all affected quantities, including $Q$-values, reaction rates, and branching ratios. We find such mass variations can result in up to an order of magnitude local change in the final abundance pattern produced in an $r$-process simulation. We identify key nuclei whose masses have a substantial impact on abundance predictions for hot, cold, and neutron star merger $r$-process scenarios and could be measured at future radioactive beam facilities.
description: 8 pages, 3 figures, submitted
Peroxidative aggregation of α-synuclein requires tyrosines
Creators: name: Olteanu, Alina
name: Pielak, Gary J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: α-Synuclein is the main component of the intracellular protein aggregates in neurons of patients with Parkinson’s disease. The occurrence of the disease is associated with oxidative damage. Although it is known that peroxidative chemistry leads to the aggregation of α-synuclein in vitro, the specific amino acid types of α-synuclein involved in this type of aggregation have not been identified. We show, using human cytochrome c plus H2O2 as the source oxidative stress, that the tyrosines of α-synuclein are required for aggregation. The studies reveal the chemical basis for a crucial step in the aggregation process.
[Pdf/ePub/Mobi] HEREDEROS DEL TIEMPO - ADRIAN TCHAIKOVSKY descargar ebook gratis
Creators: name: Carter
Publisher: name: Zenodo
Year: 2024

description: HEREDEROS DEL TIEMPO de ADRIAN TCHAIKOVSKY

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HEREDEROS DEL TIEMPO

ADRIAN TCHAIKOVSKY

Número de páginas: 518

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788498891195

Editorial: ALAMUT EDICIONES

Año de edición: 2019

 

 

 

 

 

Descargar audiolibros gratis HEREDEROS DEL TIEMPO de ADRIAN TCHAIKOVSKY (Literatura española)

 

Overview

Una carrera por la supervivencia entre las estrellas. Los últimos restos de la especie humana dejan una Tierra moribunda, ansiosos por encontrar un nuevo hogar entre las estrellas. Siguiendo los pasos de sus antecesores, descubren el mayor tesoro de una era remota: un mundo terraformado y preparado para la vida humana.Pero este nuevo Edén no es tan ideal como parece. En los largos años desde que el planeta fue abandonado, el trabajo de sus ingenieros ha dado frutos catastróficos. El planeta no se encuentra intacto ni deshabitado. Sus nuevas dueñas lo han convertido en refugio de la peor pesadilla de la humanidad. Ahora dos civilizaciones se encuentran en rumbo de colisión, y ambas afrontan los límites de lo que harán para sobrevivir. El destino de la humanidad pende de un hilo. ¿Quiénes serán los verdaderos herederos de esta nueva Tierra?"Una aproximación innovadora a las civilizaciones post distópicas, con la construcción de escenario más inteligente en términos evolutivos que jamás leeréis." --Peter F. Hamilton
Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains: Detergents Destabilize Extramembranous Soluble Domains
Creators: name: Hunt, John F.
name: Kappes, John C.
name: An, Jianli
name: DeLucas, Lawrence J.
name: Brouillette, Christie G.
name: Hildebrandt, Ellen
name: Riordan, John R.
name: Yang, Zhengrong
name: Zhou, Qingxian
name: Aleksandrov, Luba A.
name: Urbatsch, Ina L.
name: Wang, Chi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Detergent interaction with extramembranous soluble domains (ESDs) is not commonly considered an important determinant of integral membrane protein (IMP) behavior during purification and crystallization, even though ESDs contribute to the stability of many IMPs. Here we demonstrate that some generally nondenaturing detergents critically destabilize a model ESD, the first nucleotide-binding domain (NBD1) from the human cystic fibrosis transmembrane conductance regulator (CFTR), a model IMP. Notably, the detergents show equivalent trends in their influence on the stability of isolated NBD1 and full-length CFTR. We used differential scanning calorimetry (DSC) and circular dichroism (CD) spectroscopy to monitor changes in NBD1 stability and secondary structure, respectively, during titration with a series of detergents. Their effective harshness in these assays mirrors that widely accepted for their interaction with IMPs, i.e., anionic > zwitterionic > nonionic. It is noteworthy that including lipids or nonionic detergents is shown to mitigate detergent harshness, as will limiting contact time. We infer three thermodynamic mechanisms from the observed thermal destabilization by monomer or micelle: (i) binding to the unfolded state with no change in the native structure (all detergent classes); (ii) native state binding that alters thermodynamic properties and perhaps conformation (nonionic detergents); and (iii) detergent binding that directly leads to denaturation of the native state (anionic and zwitterionic). These results demonstrate that the accepted model for the harshness of detergents applies to their interaction with an ESD. It is concluded that destabilization of extramembranous soluble domains by specific detergents will influence the stability of some IMPs during purification.
Download Pdf Lonely Planet East Africa 12 by Trent Holden, Shawn Duthie, Mark Eveleigh, Mary Fitzpatrick, Neema Githere
Creators: name: Hawthorne
Publisher: name: Zenodo
Year: 2024

description: Lonely Planet East Africa 12 by Trent Holden, Shawn Duthie, Mark Eveleigh, Mary Fitzpatrick, Neema Githere

 

 

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Lonely Planet East Africa 12

Trent Holden, Shawn Duthie, Mark Eveleigh, Mary Fitzpatrick, Neema Githere

Page: 560

Format: pdf, ePub, mobi, fb2

ISBN: 9781787018228

Publisher: Lonely Planet

 

Books in pdf to download Lonely Planet East Africa 12

Overview

Lonely Planet's East Africa is our most comprehensive guide that extensively covers all the country has to offer, with recommendations for both popular and lesser-known experiences. Feel the pounding of hooves as wildebeest stampede across the Serengeti; all with your trusted travel companion. Inside Lonely Planet's East Africa Travel Guide: Lonely Planet's Top Picks - a visually inspiring collection of the destination's best experiences and where to have them Itineraries help you build the ultimate trip based on your personal needs and interests Local insights give you a richer, more rewarding travel experience - whether it's history, people, music, landscapes, wildlife, politics Eating and drinking - get the most out of your gastronomic experience as we reveal the regional dishes and drinks you have to try Toolkit - all of the planning tools for solo travellers, LGBTQIA+ travellers, family travellers and accessible travel Colour maps and images throughout Language - essential phrases and language tips Insider tips to save time and money and get around like a local, avoiding crowds and trouble spots Covers Kenya, Tanzania, Uganda, Rwanda, Burundi and more About Lonely Planet: Lonely Planet, a Red Ventures Company, is the world's number one travel guidebook brand. Providing both inspiring and trustworthy information for every kind of traveler since 1973, Lonely Planet reaches hundreds of millions of travelers each year online and in print and helps them unlock amazing experiences. Visit us at lonelyplanet.com and join our community of followers on Facebook (facebook.com/lonelyplanet), Twitter (@lonelyplanet), Instagram (instagram.com/lonelyplanet), and TikTok (@lonelyplanet). 'Lonely Planet. It's on everyone's bookshelves; it's in every traveler's hands. It's on mobile phones. It's on the Internet. It's everywhere, and it's telling entire generations of people how to travel the world.'  Fairfax Media (Australia)
Cyclic Frobenius algebras
Creators: name: Buchstaber, V. M.
name: Mikhailov, A. V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: Rings and Algebras (math.RA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper, we introduce the notion of cyclic Frobenius algebras (CF-algebras). Canonical structures of CF-algebras exist on associative and Poisson algebras. It turns out that the modern theory of integrable systems yields non-trivial examples of CF-algebras. In the theory of the KdV hierarchy there is a structure of CF-algebra which leads to explicit expressions for the first integrals of the N-th Novikov hierarchy, suitable for classical, non-Abelian and quantum cases.
Heisenberg's uncertainty principle in the PTOLEMY project: a theory update
Creators: name: PTOLEMY Collaboration
name: Apponi, A.
name: Betti, M. G.
name: Borghesi, M.
name: Boyarsky, A.
name: Canci, N.
name: Cavoto, G.
name: Chang, C.
name: Cheianov, V.
name: Cheipesh, Y.
name: Chung, W.
name: Cocco, A. G.
name: Colijn, A. P.
name: D'Ambrosio, N.
name: de Groot, N.
name: Esposito, A.
name: Faverzani, M.
name: Ferella, A.
name: Ferri, E.
name: Ficcadenti, L.
name: Frederico, T.
name: Gariazzo, S.
name: Gatti, F.
name: Gentile, C.
name: Giachero, A.
name: Hochberg, Y.
name: Kahn, Y.
name: Lisanti, M.
name: Mangano, G.
name: Marcucci, L. E.
name: Mariani, C.
name: Marques, M.
name: Menichetti, G.
name: Messina, M.
name: Mikulenko, O.
name: Monticone, E.
name: Nucciotti, A.
name: Orlandi, D.
name: Pandolfi, F.
name: Parlati, S.
name: Pepe, C.
name: Heros, C. Pérez de los
name: Pisanti, O.
name: Polini, M.
name: Polosa, A. D.
name: Puiu, A.
name: Rago, I.
name: Raitses, Y.
name: Rajteri, M.
name: Rossi, N.
name: Rozwadowska, K.
name: Rucandio, I.
name: Ruocco, A.
name: Strid, C. F.
name: Tan, A.
name: Teles, L. K.
name: Tozzini, V.
name: Tully, C. G.
name: Viviani, M.
name: Zeitler, U.
name: Zhao, F.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We discuss the consequences of the quantum uncertainty on the spectrum of the electron emitted by the $β$-processes of a tritium atom bound to a graphene sheet. We analyze quantitatively the issue recently raised in [Cheipesh et al., Phys. Rev. D 104, 116004 (2021)], and discuss the relevant time scales and the degrees of freedom that can contribute to the intrinsic spread in the electron energy. We perform careful calculations of the potential between tritium and graphene with different coverages and geometries. With this at hand, we propose possible avenues to mitigate the effect of the quantum uncertainty.
description: 14 pages, 5 figures
Scoring protein interaction decoys using exposed residues (SPIDER): A novel multibody interaction scoring function based on frequent geometric patterns of interfacial residues
Creators: name: Tropsha, Alexander
name: Khashan, Raed
name: Zheng, Weifan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Accurate prediction of the structure of protein-protein complexes in computational docking experiments remains a formidable challenge. It has been recognized that identifying native or native-like poses among multiple decoys is the major bottleneck of the current scoring functions used in docking. We have developed a novel multi-body pose-scoring function that has no theoretical limit on the number of residues contributing to the individual interaction terms. We use a coarse-grain representation of a protein-protein complex where each residue is represented by its side chain centroid. We apply a computational geometry approach called Almost-Delaunay tessellation that transforms protein-protein complexes into a residue contact network, or an un-directional graph where vertex-residues are nodes connected by edges. This treatment forms a family of interfacial graphs representing a dataset of protein-protein complexes. We then employ frequent subgraph mining approach to identify common interfacial residue patterns that appear in at least a subset of native protein-protein interfaces. The geometrical parameters and frequency of occurrence of each “native” pattern in the training set are used to develop the new SPIDER scoring function. SPIDER was validated using standard “ZDOCK” benchmark dataset that was not used in the development of SPIDER. We demonstrate that SPIDER scoring function ranks native and native-like poses above geometrical decoys and that it exceeds in performance a popular ZRANK scoring function. SPIDER was ranked among the top scoring functions in a recent round of CAPRI (Critical Assessment of PRedicted Interactions) blind test of protein–protein docking methods.
The R of FAIR: Urban Vitality data package checklist
Creators: name: Ulzen, N.R. Van
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2020
Subjects: Health Sciences

description: The ultimate goal of FAIR is to optimize the Reuse of data. To achieve this, metadata and data should be well-described and documented so that they can be replicated, understood and/or combined in different settings. Think of variable labels, codebooks, protocols and instruments used, attaching a license, etc. This checklist details what to include in a data package besides the data itself. The data package can be deposited in data repository such as UvA/HvA figshare.
Parents' Perceptions of Benefit of Children's Mental Health Treatment and Continued Use of Services
Creators: name: Fristad, Mary A.
name: Youngstrom, Eric A.
name: Storfer-Isser, Amy
name: Horwitz, Sarah
name: Hayden, Margaret
name: Axelson, David
name: Demeter, Christine
name: Birmaher, Boris
name: Findling, Robert L.
name: Arnold, L. Eugene
name: Frazier, Thomas W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To examine characteristics associated with perceived benefit from outpatient mental health services for children and to determine whether perceived benefit is related to continued use of mental health services at a 6 month follow-up.
PDF [DOWNLOAD] The Throne of Broken Gods by Amber V Nicole on Iphone
Creators: name: Sands
Publisher: name: Zenodo
Year: 2024

description: The Throne of Broken Gods by Amber V Nicole

 

 

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The Throne of Broken Gods

Amber V Nicole

Page: 712

Format: pdf, ePub, mobi, fb2

ISBN: 9798986305042

Publisher: Rose and Star Publishing

 

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Validation of Interpersonal Support Evaluation List-12 (ISEL-12) scores among English- and Spanish-speaking Hispanics/Latinos from the HCHS/SOL Sociocultural Ancillary Study.
Creators: name: Llabre, Maria M.
name: Navas-Nacher, Elena L.
name: Gallo, Linda C.
name: Ponguta, Liliana A.
name: Johnson, Timothy P.
name: Malcarne, Vanessa L.
name: Merz, Erin L.
name: Roesch, Scott C.
name: Perreira, Krista M.
name: Weitzman, Orit B.
name: Gonzalez, Franklyn
name: Penedo, Frank J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The Interpersonal Support Evaluation List-12 (ISEL-12; Cohen, Mermelstein, Kamarck, & Hoberman, 1985) is broadly employed as a short-form measure of the traditional ISEL, which measures functional (i.e., perceived) social support. The ISEL-12 can be scored by summing the items to create an overall social support score; three subscale scores representing appraisal, belonging, and tangible social support have also been proposed. Despite extensive use, studies of the psychometric properties of ISEL-12 scores have been limited, particularly among Hispanics/Latinos, the largest and fastest growing ethnic group in the United States. The present study investigated the reliability, and structural and convergent validity of ISEL-12 scores using data from 5,313 Hispanics/Latinos who participated in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary study. Participants completed measures in English or Spanish, and identified their ancestry as Dominican, Central American, Cuban, Mexican, Puerto Rican, or South American. Cronbach’s alphas suggested adequate internal consistency for the total score for all languages and ancestry groups; coefficients for the subscale scores were not acceptable. Confirmatory factor analyses revealed that the one-factor and three-factor models fit the data equally well. Results from multigroup confirmatory factor analyses supported a similar one-factor structure with equivalent response patterns and variances between language groups and ancestry groups. Convergent validity analyses suggested that the total social support score related to scores of social network integration, life engagement, perceived stress, and negative affect (depression, anxiety) in the expected directions. The total score of the ISEL-12 can be recommended for use among Hispanics/Latinos.