cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Conversion of an inactive xylose isomerase into a functional enzyme by co-expression of GroEL-GroES chaperonins in Saccharomyces cerevisiae
Creators: name: Temer, Beatriz
name: Santos, Leandro
name: Negri, Victor
name: Galhardo, Juliana
name: Magalhães, Pedro
name: José, Juliana
name: Cidnei Marschalk
name: Thamy Corrêa
name: Carazzolle, Marcelo
name: Pereira, Gonçalo
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology
subject: Computational Biology

description: Fig. S1. Analysis of possible xylose isomerase codifying genes in the genome of P. acidipropionici. [a]: possible operon containing the gene PACID_ 03490; [b]: possible operon containing the gene PACID_ 34,060; [c]: possible operon containing the gene PACID_34150 [d]: possible operon containing the gene PACID_33980. The xylA candidate genes are represented in green, closely related genes are represented in blue. Fig. S2. Agarose gel electrophoresis of xylA amplification from cDNA. BT was used as a negative control and RNA translation of xylA gene can be observed with amplification of BTXIPa and BTXI2.0 samples. Table S1. XI expressed in Saccharomyces cerevisiae. (DOC 610 kb)
The role of NOS1AP, a schizophrenia susceptibility gene, in the regulation of dendrite branching, dendritic spine formation, and actin dynamics.
Creators: name: Hernandez, Kristina
Publisher: name: No Publisher Supplied
Year: 2015

description: Proper communication between neurons is dependent upon the appropriate patterning of dendrites and the correct distribution and structure of spines. Schizophrenia is one of several neurodevelopmental disorders that are characterized by alterations in dendrite branching and spine density. NOS1AP is a protein encoded by a schizophrenia susceptibility gene, and its expression is upregulated in the dorsolateral prefrontal cortex of patients with schizophrenia. Previously, our laboratory showed that NOS1AP isoforms negatively regulate dendrite branching in cultured rat hippocampal neurons. Since dendrites and spines are influenced by changes in the cytoskeleton, we investigated whether the overexpression of NOS1AP isoforms in heterologous cells alters actin and microtubule organization. Overexpression of a long isoform of NOS1AP (NOS1AP-L) increases the presence of microtubule organizing centers, whereas overexpression of the short isoform of NOS1AP (NOS1AP-S) decreases microtubule organization. Furthermore, NOS1AP isoforms associate with F-actin in rat brain and can alter actin organization in distinct ways. NOS1AP-S increases actin polymerization, and its overexpression in HEK293T cells decreases total Rac1 and cofilin protein expression. To elucidate the role of NOS1AP in spine formation and synaptic function, we overexpressed NOS1AP isoforms in cultured rat cortical neurons. Overexpression of NOS1AP-L increases the number of immature spines, whereas overexpression of NOS1AP-S increases the number of mature and immature spines. In addition, overexpression of NOS1AP-S increases the frequency of miniature excitatory postsynaptic currents (mEPSCs) but not the amplitude. Overexpression of NOS1AP-L decreases the amplitude of mEPSCs but not the frequency. To investigate whether NOS1AP-L can mediate changes to dendrite patterning in vivo, we overexpressed NOS1AP-L in neuronal progenitor cells of the embryonic rat neocortex and analyzed dendrite patterning three weeks later. Neurons overexpressing NOS1AP-L in layers II/III of the neocortex exhibit a reduction in dendrite length and number. Finally, to investigate the role that NOS1AP plays in human dendritic arbor development, human neurons were generated using induced pluripotent stem cell technology. Overexpression of either NOS1AP-L or NOS1AP-S in human neurons results in a decrease in dendrite branching. Interestingly, treatment of human neurons with D-serine results in a reduction in NOS1AP-L protein expression. Taken together, our data support a role for NOS1AP-L and NOS1AP-S in dendritogenesis and synaptic function.
Leveraging organizational dynamics in buildings to change behavior
Creators: name: Hewitt, Elizabeth L.
Publisher: name: No Publisher Supplied
Year: 2015

description: Buildings may be stationary, but they are not static; they are dynamic and active collectives of agents and actors, and play an important cultural and social role in shaping norms and influencing outcomes in the built environment. This research develops and applies a unique framework that conceptualizes the urban multifamily residential building as an organization, and seeks to use this lens to better understand the role of organizational characteristics in influencing energy efficiency in buildings.    This work finds that an organizational analogy is a fruitful approach for understanding buildings, and that buildings in many ways can and do function successfully as organizations. In particular, eight organizational characteristics are explored here that extend well to buildings. These eight organizational characteristics are also explored more deeply to support an argument that some buildings have an organizational advantage that well positions them to undertake energy efficiency initiatives.    One organizational characteristic – the ownership type of the building – is determined to be particularly important in driving energy outcomes in multifamily buildings in New York City. In particular, it was found that cooperative buildings in the New York City housing market consume less energy citywide than other types of multifamily properties, holding all else equal. Conversely, it was also found that rental buildings tend to consume more energy citywide. Subsequent qualitative case study work in a small Brooklyn cooperative building offers a deeper understanding of organizational decentralization and its role in driving decision-making and outcomes in the building. Additional comparative work in two rental properties – one high-income and one low-income – adds additional context and understanding to economic considerations such as the influence of income in overriding centralized efforts to operate the building efficiently.   Ultimately, this research develops an analogy of buildings-as-organizations – a conceptual framework – to better understand tangible built space. It posits that all buildings can function as organizations, and extends this framework to the urban multifamily building to advance knowledge of energy efficiency.
Getting warmer
Creators: name: Howansky, Kristina
Publisher: name: No Publisher Supplied
Year: 2015

description: This work compared three competing models for the effect of psychological distance on climate change limiting behaviors. The Proximal Model suggested that reducing psychological distance could be beneficial for motivating pro-environmental actions. The Distal Model supported the notion that increasing distance from climate change could motivate action. And the Optimal Distance Model suggested the greatest amount of action should occur at a moderate distance. A manipulation of the temporal distance of climate change failed to produce effects on attitudes, intentions, or behaviors. However, examination of individual difference measures of distance provided support for the Proximal Model whereas decreasing the psychological distance between the self and climate change increased pro-environmental intentions. Further, perceiving climate change as near was related to increased concern, efficacy, and responsibility. The current work also establishes concern, efficacy, and responsibility as mediators between psychological distance and pro-environmental intentions. Theoretical implications and directions for future research as discussed.
MOESM1 of Class 1 integrons and plasmid-mediated multiple resistance genes of the Campylobacter species from pediatric patient of a university hospital in Taiwan
Creators: name: Yi-Chih Chang
name: Tien, Ni
name: Jai-Sing Yang
name: Chi-Cheng Lu
name: Fuu-Jen Tsai
name: Tsurng-Juhn Huang
name: I-Kuan Wang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. Additional tables.
Riodinella nympha
Creators: name: Jong, Rienk De
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Riodinidae
Riodinella
Riodinella nympha

description: nympha. Riodinella nympha Durden & Rose, 1978
Incertae sedis.
USA, Colorado, Rio Blanco Co., Ray Dome; early Lutetian, middle Eocene.
Depositories: PLME (holotype, no. 3a), BHM (counterpart, no. 3b).
Published figures: Durden & Rose (1978: Figs 4, 5, 6E–F); Murata (1998: Figs 4, 5).
Described as belonging to Lycaenidae (at the time including Riodinidae) and compared, among others, to the extant genus Riodina. In addition to photos of the holotype, a reconstruction of the wing venation and an extensive description is given. In the reconstruction of the hindwing a long tail at the end of M3 and CuA1 has been reproduced, or rather produced, since it is not present in the fossil. Hall et al. (2004) extensively explain that in wing venation there is nothing to link the fossil exclusively to the Riodinidae; several of the venational characters also are found in Papilionidae, Pieridae and Nymphalidae. Hall et al. (2004) conclude that it should be treated as an unplaced butterfly, with which I can fully agree.
According to the original description “the male genitalia are definitely comparable to modern members of this subtribe”, but the genitalia are not described except for a structure "in the anterior third of the capsule". This structure is interpreted as representing a Y-shaped furca, an interpretation that is considered unreliable. Apparently the specimen is supposed to be a male, but under “Characters agreeing with the family” [Lycaenidae] is listed “Prothoracic femur 0.6 of mesothoracic femur in female” (Durden & Rose 1978)
description: Published as part of Jong, Rienk De, 2017, Fossil butterflies, calibration points and the molecular clock (Lepidoptera: Papilionoidea), pp. 1-63 in Zootaxa 4270 (1) on page 33, DOI: 10.5281/zenodo.583183
Position: Machine learning-powered assessments of the EU digital services act aid quantify policy impacts on online harms
Creators: name: Bonel, Eleonora
name: Nannini, Luca
name: BASSI, DAVIDE
name: Michele, Joshua Maggini
Publisher: name: Zenodo
Year: 2025

description: While machine learning shows promise in automated knowledge generation, current techniques such as large language models and micro-targeted influence operations can be exploited for harmful purposes like the proliferation of disinformation. The European Union's Digital Services Act (DSA) is an exemplary policy response addressing these harms generated by online platforms. In this regard, it necessitates a comprehensive evaluation of its impact on curbing the harmful downstream effects of these opaque practices. Despite their harmful applications, we argue that machine learning techniques offer immense, yet under-exploited, potential for unraveling the impacts of regulations like the DSA. Following an analysis that reveals possible limitations in the DSA's provisions, we call for resolute efforts to address methodological barriers around appropriate data access, isolating marginal regulatory effects, and facilitating generalization across different contexts. Given the identified advantages of data-driven approaches to regulatory delivery, we advocate for machine learning research to help quantify the policy impacts on online harms.
Doliops sklodowskii Barsevskis 2013
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Doliops
Doliops sklodowskii

description: 27. Doliops sklodowskii Barševskis, 2013
Philippines: Luzon isl., Mountain Province, Bontoc, Mainit, 10.2020 (1, local collector leg.), 12.2020 (1, local collector leg.);: Luzon isl., Mountain Province, Barlig, 10.2019 (1, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 235, DOI: 10.5281/zenodo.10905476
SFT-based DOA detection on co-prime array
Creators: name: Huang, Guanjie
Publisher: name: No Publisher Supplied
Year: 2015

description: In the thesis, we propose a direction of arrival (DOA) estimation method with co-prime sensor  arrays based on the Sparse Fourier Transform (SFT). A co-prime array is composed of two  uniform linear arrays (ULAs) whose inter-sensor spacings are (M*lambda) /2 and (N*lambda )/2, respectively,where M and N are co-prime integers and the   represents the signal wavelength. The co-  prime array is adopted here because it can extend the degrees of freedom thus bene ting DOA  detection. Assuming that there are not many targets in the array far  eld, the array snapshot  is sparse in the spatial frequency domain. Since the spatial frequencies of the array snapshot  contain DOA information, the DFT is traditionally used to obtain DOA information. In the  thesis, the SFT is employed to estimate the DOA instead of the DFT. Compared to the DFT,  the SFT only needs a small subset of snapshot samples to estimate the signi cant coe cients.  Owing to this advantage, we design a new method to estimate DOA, using a subset of sensors.  Both analytical and computer simulations con rm the validity of the proposed approach.
The effect of lake level on sulfur isotope systematics in the Lockatong Formation of the Newark Basin, New Jersey
Creators: name: Hupfer, Ryan W.
Publisher: name: No Publisher Supplied
Year: 2015

description: The Lockatong Formation is composed of lacustrine sediments that were deposited in the Newark Basin during the Late Triassic (~222-218 Ma).  This formation is characterized by black, organic rich layers interspersed with iron-oxide rich, red layers at various intervals, both of which contain pyrite, indicating that the lake supported a community of sulfate reducing bacteria.  The stratigraphic patterns of this formation reflect cyclic depositional environments of the ancient lake from a deep, productive freshwater lake to a playa or completely dried out lake bed.  Wet-dry cycles forced by climatic changes are proposed as the primary influence on the sulfate concentration in the paleo-lakes of the Newark Basin, which influences the δ34S of sulfide, produced from bacterial sulfate reduction and is preserved in pyrite.    In modern closed systems, stratification influences sulfate concentration.  Deep lakes with euxinic bottom waters have sulfate concentrations that limit bacterial sulfate reduction producing sulfide with high δ34S values, which are preserved in sedimentary pyrite.  Conversely, low lake levels have a higher sulfate concentration, resulting in more fractionation and lower δ34S values.  This study tests this hypothesis using the varying lake levels in the Triassic Newark Basin.  Comparison of δ34S values from pyrite and sedimentary depth rankings show that deep lake pyrite samples have relatively high δ34S values (+5 ± 5 ‰) while shallow lake deposits have lower values (-6‰  ± 5 ‰).  These findings indicate a relationship between climatically controlled lake level and δ34S values that are preserved in sedimentary pyrite.
Additional file 1: Table S1. of Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients â Ľ65Â years old
Creators: name: Eraj, Salman
name: Jomaa, Mona
name: Crosby Rock
name: Mohamed, Abdallah
name: Smith, Blaine
name: Smith, Joshua
name: Browne, Theodora
name: Cooksey, Luke
name: Bowman Williams
name: Temple, Brandi
name: Preston, Kathryn
name: Aymar, Jeremy
name: Gross, Neil
name: Weber, Randal
name: Hessel, Amy
name: Ferrarotto, Renata
name: Phan, Jack
name: Sturgis, Erich
name: Ehab Hanna
name: Frank, Steven
name: Morrison, William
name: Goepfert, Ryan
name: Lai, Stephen
name: Rosenthal, David
name: Mendoza, Tito
name: Cleeland, Charles
name: Hutcheson, Kate
name: Fuller, Clifton
name: Garden, Adam
name: G. Gunn
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Proportions of patients reporting moderate to severe (â Ľ5) rating for the 22 MDASI-HN symptom items by clinical subgroups of interest. (DOCX 20Â kb)
Structural members produced from unrefined lunar regolith, a structural assessment
Creators: name: Indyk, Stephen
Publisher: name: No Publisher Supplied
Year: 2015

description: The potential of utilizing lunar regolith as the raw material for manufacturing structural members is very appealing for future exploration of the Moon. Future lunar missions will depend on in-situ resource utilization (ISRU) for structural components. Manufacturing structural components directly from unrefined lunar regolith would have the advantage of needing less specialized material processing equipment in comparison with refining the lunar regolith for its raw elements. Sintering lunar regolith has been proposed as a structural material by previous researchers but has not been evaluated for its elastic material properties. Sintering can be a highly variable process and only with the knowledge of the material constants can a structure be designed using this material.    Quantification of the material properties was performed for sintered lunar regolith by testing sintered lunar regolith simulant. Two batches of sintered lunar regolith simulant JSC-1A samples with porosities 1.44% and 11.78% underwent compression testing using an Instron series 4500 Universal Test System machine. Material properties were evaluated from the load vs. deflection data acquired. Stress, strain, modulus of elasticity, toughness, the compression strength, bulk modulus, Poisson’s ratio and compressive strength were evaluated as a function of porosity and data were aggregated as probability density functions. The average compressive strengths of the low porosity material were 202 MPa, and 84 MPa for the high porosity material. By comparing these values with other ISRU derived structural materials, sintered lunar regolith is expected to be one of the strongest material derived from lunar sources.
Nymphalites obscurum
Creators: name: Jong, Rienk De
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Nymphalites
Nymphalites obscurum

description: obscurum. Nymphalites obscurum Scudder, 1889
Nymphalidae.
USA, Colorado, Teller County, Florissant; late Priabonian, late Eocene. Depository: MCZH (holotype, no. 7768).
Published figures: Emmel et al. (1992: Fig. 1 /8); Scudder (1889: Pl. LIII Figs 1 0–13). A badly preserved fossil with a stout body. Possibly a male, as parts of the uncus (“curving sides of the tapering hook of the upper organ”) seem to be present. According to the original description the “ordinary form of superior apical branching seen in the subcostal vein [now considered to be the radius] of the fore wings of Nymphalinae appears also here.” This is a rather cryptic description, and not supported by Scudder’s own figure, where few venational details are discernible. Moreover, the usual radial arrangement in Nymphalidae, the formula 1, 2, 3+(4+5), apparently is plesiomorphic. Forelegs reduced, terminal tarsal joint with short slender spines instead of the normal claw. This is an apomorphy of Nymphalidae and Lycaenidae (males only). Because of the size of the insect (wing span is estimated at 63 mm), it is unlikely that it belongs to the Lycaenidae, the Nymphalidae thus being the most likely family. Nothing more can be said about the systematic position of the fossil. It is not clear on which evidence Emmel et al. ’s (1992) remark is based that “its closest affinities seem to be with Marpesia and Anaea from Mexico and Central America” which, according Freitas & Brown (2004), based on morphology, and Wahlberg et al. 2009, based on molecular analysis, are in separate subfamilies of Nymphalidae; Marpesia is in Cyrestinae, Anaea in Charaxinae).
description: Published as part of Jong, Rienk De, 2017, Fossil butterflies, calibration points and the molecular clock (Lepidoptera: Papilionoidea), pp. 1-63 in Zootaxa 4270 (1) on page 33, DOI: 10.5281/zenodo.583183
MOESM1 of Class 1 integrons and plasmid-mediated multiple resistance genes of the Campylobacter species from pediatric patient of a university hospital in Taiwan
Creators: name: Yi-Chih Chang
name: Tien, Ni
name: Jai-Sing Yang
name: Chi-Cheng Lu
name: Fuu-Jen Tsai
name: Tsurng-Juhn Huang
name: I-Kuan Wang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. Additional tables.
Nanotechnology approaches for inhalation treatment of fibrosis
Creators: name: Ivanova, Vera
Publisher: name: No Publisher Supplied
Year: 2015

description: Idiopathic Pulmonary Fibrosis (IPF) is very insidious and untreatable disease. While many investigations are focused on the pathogenesis of the disease this disorder does not have reliable  therapeutic options and  an  effective  therapy has yet to  be identified and developed.   Pulmonary fibrosis has been mainly treated for secondary symptoms  with  some  success,  but  unfortunately  patients  succumb  to  the  disease. While cystic fibrosis is caused by mutation in chlorine transporter gene CFTR, idiopathic pulmonary fibrosis is developed similarly to cancer due to various environmental factors combined  with  genetic.    Antibiotic  treatments  have  prolonged  the  survival  rate  of children suffering from cystic fibrosis to forty years.  Meanwhile, various treatments for idiopathic pulmonary fibrosis were less successful with general survival rate less than 3 years.  All of the current treatments address secondary symptoms rather than the cause of the disease.  Therefore, it is very vital to develop new treatment for debilitating fibrotic  diseases.  In our study we focused on the pulmonary form of fibrosis. It is natural to use local administration of drugs by inhalation for treating of - respiratory diseases. Some of the respiratory drugs nowadays are being repositioned for local treatment. With successful inhalation devices and monitoring, local delivery to the lungs has higher efficacy due to administering lower doses directly at the site of action and potentially eliminating systemic toxicity.  Nanotechnology is referred to the field that deals with particles in nanometer size range, which gives higher surface area and bioavailability to its desired therapeutic components.   Nanoparticles improve treatments by increasing stability, solubility, and providing sustained  release  of  therapeutic agent,  which  results  in  reduced  dosage frequency and higher patient compliance.  The overall purpose of this work is to develop, characterize and evaluate in vitro and in vivo novel inhalational nanotechnology-based treatment for idiopathic pulmonary - and cystic fibroses.  In the dissertation we are planning to focus on the: (1) to design bleomycin animal model of idiopathic pulmonary fibrosis and to test novel inhalational treatment approach using liposomal form of Prostaglandin E2 (PGE2); (2) to develop multifunctional targeted nanosystem for the delivery of siRNA and PGE2 into the lungs of mice with IPF;  (3) to develop and evaluate nanosystem containing two drugs with different mechanisms of action  for treatment of cystic fibrosis.
Life cycle assessment of hemicellulose-based products
Creators: name: Rettenmaier, Nils
name: Weise, Sonja
name: Keller, Heiko
name: Reinhardt, Guido
Publisher: name: Zenodo
Year: 2024

description: The BioSPRINT project investigated innovative, intensified processes for the optimised production of novel bio-based products from hemicellulose. These novel bio-based products are substitutes for fossil-based polyurethane (PU) foam and wood laminate binder. The aim of the present Life Cycle Assessment (LCA) study in D6.3 is to i) evaluate the potential environmental benefits of the innovative processes and ii) compare the environmental impact of the hemicellulose-based products with that of their conventional/fossil equivalents.
Mesoporous silica nanomaterial-supported Fe(III) catalysts for epoxide ring-opening reaction
Creators: name: Jaffar, Ahmed
Publisher: name: No Publisher Supplied
Year: 2015

description: The interest in the development of new heterogeneous catalysts remains unabated because of their long proven uses in industries as well their prospects of applications in several new and existing industrial and commercial processes. In this respect, mesoporous silica nanomaterials provide a unique advantage for making new and better heterogeneous catalysts because of their surface silanols, which allow for not only for further functionalization but also as catalytic moieties themselves. However, the lack of full knowledge regarding their structure-property relationship has often limited the synthesis of mesoporous silica-based heterogeneous catalysts for a range of catalytic applications. In this project, the effects of different solvents on the density of grafted catalytic groups on mesoporous silica (SBA-15) and the catalytic activity of the resulting materials have been investigated by grafting N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (diamine) and 2-(diphenylphosphino)ethyltriethoxysilane (pph2) in toluene and 2-propanol. This procedure produced two materials with diamine and pph2 ligands, respectively. The materials were then coordinated with Fe(III), and the catalytic properties and activities of the resulting materials were tested for epoxide ring opening reaction. The effect of the ligands as well as the indirect influence of solvent dependent grafting has been discussed.
Aggregation inhibition of Parkinson's related alpha-synuclein through interactions with its homolog beta-synuclein.
Creators: name: Janowska, Maria K.
Publisher: name: No Publisher Supplied
Year: 2015

description: Alpha-synuclein (αS) and beta-synuclein (βS) are small pre-synaptic, neuronal proteins, which have high sequence similarity, co-localize and very likely play a similar function in cells. However, αS and βS differ significantly in terms of their involvement in Parkinson's disease:  while αS aggregation is believed to be a centerpiece and main hallmark of the disease, non-fibrillar βS is held to be a negative regulator of αS toxicity. In my research I focused on uncovering the basis for the non-aggregating properties of βS and understanding the basis of inhibition of αS aggregation by βS.   In my research I used integrated biophysical approach primarily focusing on NMR with compliments from CD, DLS, ESI-MS, aggregation assays, cell toxicity assays, chromatography and TEM. Using paramagnetic relaxation enhancement (PRE) I was able to obtain the first ever contact maps for alpha synuclein transient dimers. A similar approach enabled me to discriminate between interactions of alpha synuclein homo-dimers and alpha/beta hetero-dimers which shed light on the interactivity profiles of alpha and beta synuclein. PRE titrations further revealed additional differences in the interactive propensities of these two proteins, that possibly give rise to the differences in aggregation rates. Thus, I was able to provide an initial answer to the first question: beta synuclein can inhibit alpha synuclein aggregation through specific weak interactions that can slow down formation of the aggregation prone complexes. I also sought to extend the knowledge about the inhibition of αS aggregation by βS by characterizing inhibition events at the later stages of aggregation that involve higher order species such as oligomers.   I further investigated the molecular determinants of  P123H, a beta synuclein mutant that switches beta synuclein from being a non-toxic to a toxic species. I discovered that the mutation in the C-terminus induces a conformational change in the P123H ensemble that leads to a collapse of the C-terminus. It is especially interesting that this one mutation can exacerbate the effect of alpha synuclein aggregation, suggesting again that the extension of the synuclein C-terminus plays an important regulatory role in aggregation and inhibition. Coupled together these facts suggest that beta-synuclein’s conformational characteristics make it particularly well-suited to inhibit alpha synuclein aggregation, which in turn provides a good candidate platform for developing inhibitors of alpha synuclein aggregation.
Molecular dynamics of crystals
Creators: name: Janowski, Paul A.
Publisher: name: No Publisher Supplied
Year: 2015

description: We present a broad effort at the development of crystal simulation methodology and its application  to benefit both macromolecular crystallography and molecular dynamics methods. Crystallography is  the current method of choice for structural determination of biomolecules, but it is hampered by the  inherently time and space-averaged nature of the experiment as well as methodological limitations that  do not sufficiently account for the heterogeneous and dynamic nature of crystals. Molecular dynamics  has proven itself as a method capable of probing the physics and chemistry of biomolecules on an  atomic scale, but requires continued development of the underlying force field parameters to more  accurately reproduce observables. Our effort has focused on developing the framework for molecular  dynamics simulations of biomolecular crystals. We first present our methodology for performing  crystal simulations and show how it is applied first to simple peptide crystals and then to increasingly  complex biomolecular systems. We demonstrate the the utility of crystal simulations for validation of  molecular dynamics. Then we show the improvement to crystallographic methods that can be gained  by incorporating molecular dynamics methods. Our work is of significant benefit to both the molecular  dynamics and macromolecular crystallography communities and proposes specific approaches to  integrate the two fields for the benefit of both.
NASAL AND THROAT DISEASES IN CHILDREN, THEIR PREVALENCE, PREVENTION AND THE IMPORTANCE OF FAMILY REHABILITATION
Creators: name: Boliev, Islomjon
name: Mukhammadieva, Munisa
name: Shamatov, Islom
Publisher: name: Zenodo
Year: 2025

description: This article discusses nasal and throat diseases in children, their prevalence, prevention and the importance of family rehabilitation during the disease process. It considers early detection and accurate diagnosis of the disease, along with children's adherence to hygiene rules as the main criteria. Children with ENT diseases are more likely to develop other diseases, including viral and allergic diseases, respiratory failure, changes in visual function, emotional lability, and rheumatological diseases. Taking this into account, the article provides information on the analysis of the correct care and treatment of the nasal cavity and nasopharynx from the initial stages of various inflammatory processes.
Creation of a novel ETV6-Cre reporter mouse model for ETV6-related fusion protein analysis  and  characterization of Ink4ab/ Vav-Cre transgenic mice Lines
Creators: name: Jones, Daniel William
Publisher: name: No Publisher Supplied
Year: 2015

description: Creation of a Novel ETV6-Cre Reporter Mouse Model for ETV6-Related Fusion Protein Analysis:    The ETV6 gene is one of the most commonly targeted genes for chromosomal translocation in leukemia.  ETV6 has been found to play a key role in hematopoiesis and maintenance of embryonic vascular development, yet its role in B-cell precursor acute lymphoblastic leukemia has yet to be fully determined in respect to both gene expression localization and interactions with other proteins.  In this study, we focus on the creation of a novel transgenic line of ETV6-mCherry-CreERT2 mice that can be used both as a reporter for ETV6 expression and to drive ETV6-specific expression of Cre-ERT2 in mice with ETV6-related fusions using recombineering strategies.      Characterization of Ink4ab/ Vav-Cre Transgenic Mice Lines:    The Ink4ab genetic locus encodes for three essential proteins involved in tumor suppression, designated p15, p16, and p19 in mice.  Full knockout models of this locus have been shown to exhibit accelerated tumorigenesis in multiple forms of cancer (Krimpenfort et al., 2007).  By combining the Vav promoter, a promoter that first targets fetal liver hematopoietic stem cells, with a Cre-Lox system to allow full knock out of Ink4ab in only hematopoietic stem cells, we theorize the possibility of creating a hematopoietic system-based malignancy.  Dissections have shown that Ink4ab+/-; Vav-Cre+ and Ink4ab-/-; Vav-Cre+ mice have splenic hyperplasia, tumor growth in both liver and spleen, and ascites in the peritoneal cavity. Peripheral blood analysis of Ink4ab-/-; Vav-Cre+ mice showed the presence of lymphoblasts, abnormal erythrocytes, and apoptotic neutrophils.  Immunohistochemical staining has shown that Ink4ab-/-; Vav-Cre+ mice have increased apoptosis in T-cells, decreased mature B-cell and T-cell presence, increased cellular proliferation, deregulated cell cycle, and leukemia and lymphoma formation. These studies reveal a novel model for studying hematopoietic cell development, leukemia formation, and lymphoma formation.
Doliops stradinsi Barsevskis 2013
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Doliops
Doliops stradinsi

description: 28. Doliops stradinsi Barševskis, 2013
Philippines: Luzon isl., Mountain Province, Bontoc, Mainit, 08.2019 (5, local collector leg.), 09.2019 (2, local collector leg.), 12.2020 (2, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 235, DOI: 10.5281/zenodo.10905476
Performing race and shaping community in the black barbershop
Creators: name: Jones, Shatima Jenique
Publisher: name: No Publisher Supplied
Year: 2015

description: Ever since Du Bois described the double consciousness, scholars have debated if African-Americans hold a distinct worldview because of experiencing racial stigma. Yet controversies surrounding cultural explanations for racial disparities in education and poverty led sociologists to abandon the question of whether blacks enact unique beliefs and values. This ethnography of a Brooklyn, NY barbershop examines how black men perceive and talk about culture and morality through a racial lens and use folk conceptions of race to guide interaction. Building on conceptualizations of the double consciousness and race as performance as well as research on race and place, I find that the men: (1) sometimes express beliefs and values that they claim are uniquely black, while at other times frame conforming to “mainstream” values as “acting black;” (2) deploy notions of an “authentic” black worldview to judge the actions of whites and blacks; and (3) are pressured to put on racial performances in the barbershop. By showing when and how blacks perceive beliefs, values, and practices in relation—and in opposition—to whites, this study of a “racial backstage” shows how a black worldview is accomplished and moralized in interaction and furthers efforts to bring culture back into racial theorizing.
Fanessa pluto
Creators: name: Jong, Rienk De
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Pieridae
Fanessa
Fanessa pluto

description: pluto. Vanessa pluto Heer, 1849
Figs 11–13.
Pieridae: Coliadinae + Pierinae.
Croatia, Radoboj, Croatia; Burdigalian, early Miocene.
Depository: NHMW (holotype, no. 1940/0001/0011).
Published figure: Murata (1998: Figs 27, 28); Pongrácz (1928: Fig. 30); Scudder (1875: Pl. II Figs 2, 7, 17).
This specimen consists of the greater part of both forewings and basal fragments of hindwings. Original description and figure copied in Scudder (1875: 44–50). Considered to belong to Nymphalidae by Heer (and followed by some other authors, see discussion by Scudder) on the basis of a peculiar and highly unlikely venational arrangement: Sc arising from R halfway between base and apex, together with the common stalk of R1 and R2 (which forks shortly thereafter) and the common stalk of R3, R4 and R5, while M1 originates from the radial stem before this trichotomy; the cell is open. Such an arrangement is not found in any extant species.
Scudder’s interpretation is very different, with Sc from base as usual; the radial branching is not clearly visible, partly because the apex is broken, but it seems that M1 branches off an R-branch (formula R1, R2, (R3+M1)). This arrangement, with M1 branching off an R-branch, is found in a number of genera belonging to Coliadinae and Pierinae (see phylogeny by Wahlberg et al. 2014), and Scudder apparently was correct in considering the fossil attributable to the Pieridae. He placed it in his genus Mylothrites (followed by Kozlov 1988) and compared it to the recent genera Mylothris (Africa) and Hebomoia (Southeastern Asia) (Pieridae: Pierinae), both which have only three radial veins. Three radial veins are also found in the American genus Nathalis (Pieridae: Coliadinae), so we cannot identify the fossil more precisely than belonging to Coliadinae + Pierinae. Pongrácz (1928) re-examined the type and concluded that it was close to the satyrine genus Satyrus (Nymphalidae). However, in view of the state of preservation of the fossil of which a photograph of the holotype has been published by Ponomarenko & Schultz 1988: Pl. 7 Fig. 2, Pongrácz’s reconstruction (his Fig. 30) must have been erroneous. Without providing reasons, Handlirsch (1908) mentioned the fossil under “ Papilionidae ”, Handlirsch (1925) under “ Papilioninae ”, and Zeuner (1942) under " Nymphalinae ".
description: Published as part of Jong, Rienk De, 2017, Fossil butterflies, calibration points and the molecular clock (Lepidoptera: Papilionoidea), pp. 1-63 in Zootaxa 4270 (1) on pages 34-36, DOI: 10.5281/zenodo.583183
D5.9 Updated Sustainability Plan
Creators: name: Giuffrida, Maria
name: de Majo, Claudio
Publisher: name: Zenodo
Year: 2024

description: This deliverable outlines the outcomes and future sustainability strategies for the UNLOCK-CEI project, with a focus on two key tools developed within the lifetime of the initiative: the CEI-Radar and the CEI-LING tool. These tools provide actionable insights into demand-side market trends and company readiness for Cloud-Edge-IoT (CEI) adoption. With their integration into the follow-up CEI-Sphere project, this document highlights their role in supporting large-scale pilots and driving innovation within the CEI ecosystem.
Additional file 2: of A two-state comparative implementation of peer-support intervention to link veterans to health-related services after incarceration: a study protocol
Creators: name: Simmons, Molly
name: Fincke, Benjamin
name: Mari-Lynn Drainoni
name: Kim, Bo
name: Byrne, Tom
name: Smelson, David
name: Casey, Kevin
name: Ellison, Marsha
name: Visher, Christy
name: Blue-Howells, Jessica
name: D. McInnes
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: SPIRIT Checklist. (DOC 100Â kb)
Coliates proserpina
Creators: name: Jong, Rienk De
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Pieridae
Coliates
Coliates proserpina

description: proserpina. Coliates Scudder, 1875
Family incertae sedis.
France, Bouches-du-Rhône, Aix-en-Provence; late Oligocene–early Miocene.
Depository: MNHN (probably).
Published figures: Leestmans (1983: Fig. 5); Scudder (1875: Pl. II Fig. 5).
Only forewings are available in this specimen. It seems that R2 is missing or fused with R1, while M1 is stalked on the common stem of R3, R4 and R5. The latter condition is widespread in Pieridae, but recurs in some Lycaenidae and in one genus (Microtia) of Nymphalidae and, thus, is insufficient to identify the fossil as a pierid. Scudder compared the fossil to Delias (Pieridae, India to Australia), but in this genus there are only three radial branches present. In most pierid genera two radial branches (R1 and R2) arise free from the cell. The fossil does not exhibit additional further characters that could be helpful phylogenetically; we can only identify the fossil as belonging to the Pieridae. Apparently based on Scudder’s comparison of the fossil with Delias and not on a personal inspection of the fossil or of the description, Braby et al. (2006) considered the closest relative the Delias- Prioneris group (possibly Aporia), and used it as calibration point for this node in the phylogeny of the Pieridae, thus taking the risk that it greatly overestimates the divergence ages in Pieridae.
description: Published as part of Jong, Rienk De, 2017, Fossil butterflies, calibration points and the molecular clock (Lepidoptera: Papilionoidea), pp. 1-63 in Zootaxa 4270 (1) on page 36, DOI: 10.5281/zenodo.583183
Exploring the link between high performance work systems and innovation
Creators: name: Kang, Saehee
Publisher: name: No Publisher Supplied
Year: 2015

description: This study examines processes linking high-performance work systems (HPWS) and innovation performance. I propose that HPWS are positively related to innovative climate, individual creativity, and organizational innovation. This study further investigates the possibility that the relations between HPWS and creativity and innovation are moderated by innovative climate. Based on a sample of R&D units in South Korea, this study provides novel insight into how firms can facilitate innovation process in such a way that creative ideas are successfully produced and implemented for innovation.
Additional file 2: Figure S1. of Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy
Creators: name: Milad, Nadia
name: White, Zoe
name: Tehrani, Arash
name: Sellers, Stephanie
name: Rossi, Fabio
name: Bernatchez, Pascal
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: Plasma lipid levels at 4 months of age on Western diet. Plasma CK in IU/L (A), total cholesterol in mmol/L (B), HDL in mmol/L (C) and TG in mmol/L (D) at 4 months of age on Western diet. WT (n = 4), ApoE (n = 4), mdx (n = 7), and mdx-ApoE (n = 5). Mean + SEM. *P
Lamprobityle rugulata
Creators: name: Barševskis, Arvīds
name: Barševska, Zeltīte
name: Vanaga, Anarina
name: Borodina, Olga
name: Roze, Liāna
name: Pilace, Sanda
name: Mantilla, Leslae Kay Cataytay
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Lamprobityle
Lamprobityle rugulata

description: 29. Lamprobityle rugulata (Vives, 2012)
Philippines: Luzon isl., Nueva Viscaya, Belance, 03.2019 (2, local collector leg.).
description: Published as part of Barševskis, Arvīds, Barševska, Zeltīte, Vanaga, Anarina, Borodina, Olga, Roze, Liāna, Pilace, Sanda & Mantilla, Leslae Kay Cataytay, 2021, To the knowledge of long-horned beetles (Coleoptera: Cerambycidae) of the Oriental Region (with new synonymy). Part 4, pp. 229-247 in Baltic Journal of Coleopterology 21 (2) on page 235, DOI: 10.5281/zenodo.10905476
Anomaly detection in network using non-negative matrix factorization techniques
Creators: name: Kang, Yunyi
Publisher: name: No Publisher Supplied
Year: 2015

description: Anomaly detection is becoming an important problem in graph mining. This is because people are eager to find out unusual objects or patterns in a network, which may results in possible damages, emerging trends, or even creations in different types of graphs or networks. For example, the transaction occurs in out-of- hometown area with high amount may indicate credit card fraud in a bank transaction network; a substantial high frequency of connectivity in the network may infer possible web attack. The discoveries of these activities are important for people’s life and personal information security, and thus are important tasks for relevant institutions. There are mainly three kinds of anomalies in a graph data: node, edge and subgraph anomaly. This thesis presents new graph anomaly detection algorithms that provide scoring functions on detecting both node anomalies and edge anomalies based on non-negative matrix factorization techniques. The experiments on real life data verify that the suggested method could provide better performance in finding meaningful anomalies.