cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BAYESIAN METHODS FOR JOINT MODELING OF LONGITUDINAL AND SURVIVAL DATA WITH APPLICATIONS TO CANCER VACCINE TRIALS
Creators: name: Ibrahim, Joseph
name: Chen, Ming-Hui
name: Sinha, Debajyoti
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Vaccines have received a great deal of attention recently as potential therapies in cancer clinical trials. One reason for this is that they are much less toxic than chemotherapies and potentially less expensive. However, little is currently known about the biologic activity of vaccines and whether they are associated with clinical outcome. The antibody immune measures IgG and IgM have been proposed as potential useful measures in melanoma clinical trials because of their observed association with clinical outcome in pilot studies. To better understand the role of the IgG and IgM antibodies for a particular vaccine, we examine a case study in melanoma and investigate the association between clinical outcome and an individual’s antibody (IgG and IgM titers) history over time. The Cox proportional hazards model is used to study the relationship between the antibody titers as a time varying covariate and survival. We develop a Bayesian joint model for multivariate longitudinal and survival data and give its biologic motivation. Various scientific features of the model are discussed and interpreted. In addition, we present a model assessment tool called the multivariate L measure that allows us to formally compare different models. A detailed analysis of a recent phase II melanoma vaccine clinical trial conducted by the Eastern Cooperative Oncology Group is presented.
Additional file 1 of Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT): study protocol for an effectiveness-implementation hybrid randomized control trial
Creators: name: Tan, Bryan Yijia
name: Pereira, Michelle Jessica
name: Su-Yin Yang
name: Hunter, David J.
name: Soren Thorgaard Skou
name: Thumboo, Julian
name: Car, Josip
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Neuroscience
Biotechnology
Science Policy

description: Appendix 1 – Intervention Description. (DOCX 26 kb)
Additional file 1 of Building trust: Leadership reflections on community empowerment and engagement in a large urban initiative
Creators: name: Lansing, Amy E.
name: Romero, Natalie J.
name: Siantz, Elizabeth
name: Silva, Vivianne
name: Center, Kimberly
name: Casteel, Danielle
name: Gilmer, Todd
Publisher: name: figshare
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Additional file 1.
Additional file 3 of Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT): study protocol for an effectiveness-implementation hybrid randomized control trial
Creators: name: Tan, Bryan Yijia
name: Pereira, Michelle Jessica
name: Su-Yin Yang
name: Hunter, David J.
name: Soren Thorgaard Skou
name: Thumboo, Julian
name: Car, Josip
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Neuroscience
Biotechnology
Science Policy

description: Appendi× 3 – Cost Questionnaire. (DOCX 43 kb)
Generalized Fiducial Inference via Discretization
Creators: name: Hannig, Jan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: In addition to the usual sources of error that have been long studied by statisticians, many data sets have been rounded off in some manner, either by the measuring device or storage on a computer. In this paper we investigate theoretical properties of generalized fiducial distribution introduced in Hannig (2009) for discretized data. Limit theorems are provided for both fixed sample size with increasing precision of the discretization, and increasing sample size with fixed precision of the discretization. The former provides an attractive definition of generalized fiducial distribution for certain types of exactly observed data overcoming a previous non-uniqueness due to Borel paradox. The latter establishes asymptotic correctness of generalized fiducial inference, in the frequentist, repeated sampling sense, for i.i.d. discretized data under very mild conditions.
title: SentiNet: Twitter-basierter Ansatz zur kombinierten Netzwerk- und Stimmungsanalyse in Katastrophenlagen
Creators: name: Kaufhold, Marc-André
name: Schmidt, Arne
name: Seifert, Fabienne
name: Riebe, Thea
name: Reuter, Christian
Publisher: name: Gesellschaft für Informatik e.V
Year: 2022

description: Das Forschungsfeld Social Media Analytics untersucht Methoden zur Analyse sozialer Medien nicht nur für Bürger und Unternehmen, sondern auch für Einsatzkräfte in Notsituationen. Zur Unterstützung des Situationsbewusstseins in derartigen Lagen werden unter anderem soziale Netzwerkanalysen angewandt, um Handlungen und die Vernetzung von Helfern nachzuvollziehen, sowie Stimmungsanalysen, um Emotionen der nutzergenerierten Inhalte zu extrahieren. Unsere Literaturstudie zeigt allerdings, dass keine technischen Ansätze existieren, die Netzwerk- und Stimmungsanalysen kombinieren. Dieser Beitrag stellt das Design und die Implementierung einer solchen Web Anwendung auf Basis von Twitter vor, um anschließend Potenziale und Herausforderungen für die Evaluation und Weiterentwicklung des Ansatzes zu diskutieren.
Additional file 4 of Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT): study protocol for an effectiveness-implementation hybrid randomized control trial
Creators: name: Tan, Bryan Yijia
name: Pereira, Michelle Jessica
name: Su-Yin Yang
name: Hunter, David J.
name: Soren Thorgaard Skou
name: Thumboo, Julian
name: Car, Josip
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Neuroscience
Biotechnology
Science Policy

description: Appendix 4 – SPIRIT diagram. (DOC 74 kb)
Towards a complete $A_4 \times SU(5)$ SUSY GUT
Creators: name: Björkeroth, Fredrik
name: de Anda, Francisco J.
name: Varzielas, Ivo de Medeiros
name: King, Stephen F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a renormalisable model based on $A_4$ family symmetry with an $SU(5)$ grand unified theory (GUT) which leads to the minimal supersymmetric standard model (MSSM) with a two right-handed neutrino seesaw mechanism. Discrete $\mathbb{Z}_9\times \mathbb{Z}_6$ symmetry provides the fermion mass hierarchy in both the quark and lepton sectors, while $\mathbb{Z}_4^R$ symmetry is broken to $\mathbb{Z}_2^R$, identified as usual R-parity. Proton decay is highly suppressed by these symmetries. We discuss both the $A_4$ and $SU(5)$ symmetry breaking sectors, including doublet-triplet splitting, Higgs mixing and the origin of the $μ$ term. The model provides an excellent fit (better than one sigma) to all quark and lepton (including neutrino) masses and mixing with spontaneous CP violation. With the $A_4$ vacuum alignments, $(0,1,1)$ and $(1,3,1)$, the model predicts the entire PMNS mixing matrix with no free parameters, up to a relative phase, selected to be $2π/3$ from a choice of the nine complex roots of unity, providing a direct link between neutrino oscillations and leptogenesis.
description: 30 pages, 17 figures, 7 tables; Minor changes, references added, version accepted in JHEP
A statistical assessment of Buchanan's vote in Palm Beach County
Creators: name: Smith, Richard L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: This article presents a statistical analysis of the results of the 2000 U.S. presidential election in the 67 counties of Florida, with particular attention to the result in Palm Beach county, where the Reform party candidate Pat Buchanan recorded an unexpectedly large 3,407 votes. It was alleged that the "butterfly ballot" had misled many voters into voting for Buchanan when they in fact intended to vote for Al Gore. We use multiple regression techniques, using votes for the other candidates and demographic variables as covariates, to obtain point and interval predictions for Buchanan's vote in Palm Beach based on the data in the other 66 counties of Florida. A typical result shows a point prediction of 371 and a 95% prediction interval of 219-534. Much of the discussion is concerned with technical aspects of applying multiple regression to this kind of data set, focussing on issues such as heteroskedasticity, overdispersion, data transformations and diagnostics. All the analyses point to Buchanan's actual vote as a clear and massive outlier.
$a_1(1420)$ resonance as a tetraquark state and its isospin partner
Creators: name: Chen, Hua-Xing
name: Cui, Er-Liang
name: Chen, Wei
name: Steele, T. G.
name: Liu, Xiang
name: Zhu, Shi-Lin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We systematically construct tetraquark currents of $I^GJ^{PC}=1^-1^{++}$ and classify them into types $\mathbf{A}$ (antisymmetric), $\mathbf{S}$ (symmetric) and $\mathbf{M}$ (mixed), based on flavor symmetries of diquarks and antidiquarks composing the tetra quark currents. We use tetraquark currents of type $\mathbf{M}$ to perform QCD sum rule analyses, and find a tetraquark current $η^M_{5μ}$ with quark contents $q s\bar q \bar s$($q=u$ or $d$) leading to a mass of $1.44 \pm 0.08$ GeV consistent with the $a_1(1420)$ state recently observed by the COMPASS collaboration. Our results support tetraquark explanations for both $a_1(1420)$ and $f_1(1420)$, assuming that they are isospin partners. We also study their possible decay patterns. As tetraquark candidates, the possible decay modes of $a_1(1420)$ are $S$-wave $a_1(1420) \rightarrow K^*(892)K$ and $P$-wave $a_1(1420)\rightarrow f_0(980) π$ while the possible decay patterns of $f_1(1420)$ are $S$-wave $f_1(1420) \rightarrow K^*(892)K$ and $P$-wave $f_1(1420) \rightarrow a_0(980) π$. We speculate that $a_1(1420)$ is partly responsible for the large isospin violation in the $η(1405)\to f_0(980)π_0$ decay mode which is reported by BESIII collaboration in the $J/ψ\toγ3π$ process.
description: 15 pages, 8 figures. Accepted by Phys. Rev. D
DPCfam PUA_UR50 and P53_UR50 datasets and metaclusters
Creators: name: Russo, Elena Tea
Publisher: name: Zenodo
Year: 2020

description: This zip contains data used in DPCfam to analyise PUA_UR50 and P53_UR50 datasets (paper in submission). Each folder, named as the dataset, contains two files:
 - all.fasta (fasta file containing the query sequences of the dataset)
 - all_blasted_out.txt (alignments produced running blast using the respective all.fasta file)
 To analyze these files, you can use the DPCfam0 program at https://gitlab.com/ETRu/dpcfam (see the repository README on how to use these data) Moreover, each folder contains an "MCs" folder.
 Here final MCs, filtered at 95 PI with CD-HIT,are stored. Each MC file is a fasta file named as the numbered MC discussed in the paper. Each sequence is named using its protein's Uniref50 identifier and, separated by a | , the starting and the endig position of the sequence along the given protein. Note that the sequences reported are NOT the full protein, but the specific sequence located at the starting-ending position written in the sequence name. Note, finally, that the enumeration of the MCs reported corresponds to the enumeration in the paper tables (2 and 4), and NOT with the enumeration produced by the algorithm.
Robust criticality of Ising model on rewired directed networks
Creators: name: Lipowski, Adam
name: Gontarek, Krzysztof
name: Lipowska, Dorota
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We show that preferential rewiring, which is supposed to mimick the behaviour of financial agents, changes a directed-network Ising ferromagnet with a single critical point into a model with robust critical behaviour. For the non-rewired random graph version, due to a constant number of links out-going from each site, we write a simple mean-field-like equation describing the behaviour of magnetization; we argue that it is exact and support the claim with extensive Monte Carlo simulations. For the rewired version, this equation is obeyed only at low temperatures. At higher temperatures, rewiring leads to strong heterogeneities, which apparently invalidates mean-field arguments and induces large fluctuations and divergent susceptibility. Such behaviour is traced back to the formation of a relatively small core of agents which influence the entire system.
description: 6 pages, minor changes, Phys.Rev. E (accepted)
A Periodically Varying Luminous Quasar at z=2 from the Pan-STARRS1 Medium Deep Survey: A Candidate Supermassive Black Hole Binary in the Gravitational Wave-Driven Regime
Creators: name: Liu, Tingting
name: Gezari, Suvi
name: Heinis, Sebastien
name: Magnier, Eugene A.
name: Burgett, William S.
name: Chambers, Kenneth
name: Flewelling, Heather
name: Huber, Mark
name: Hodapp, Klaus W.
name: Kaiser, Nicholas
name: Kudritzki, Rolf-Peter
name: Tonry, John L.
name: Wainscoat, Richard J.
name: Waters, Christopher
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Supermassive black hole binaries (SMBHBs) should be an inevitable consequence of the hierarchical growth of massive galaxies through mergers, and the strongest sirens of gravitational waves (GWs) in the cosmos. And yet, their direct detection has remained elusive due to the compact (sub-parsec) orbital separations of gravitationally bound SMBHBs. Here we exploit a theoretically predicted signature of a SMBHB in the time domain: periodic variability caused by a mass accretion rate that is modulated by the binary's orbital motion. We report our first significant periodically varying quasar detection from the systematic search in the Pan-STARRS1 (PS1) Medium Deep Survey. Our SMBHB candidate, PSO J334.2028+01.4075, is a luminous radio-loud quasar at $z=2.060$, with extended baseline photometry from the Catalina Real-Time Transient Survey, as well as archival spectroscopy from the FIRST Bright Quasar Survey. The observed period ($542 \pm 15$ days) and estimated black hole mass ($\log (M_{\rm BH}/M_\odot) = 9.97 \pm 0.50$), correspond to an orbital separation of $7^{+8}_{-4}$ Schwarzschild radii ($\sim 0.006^{+0.007}_{-0.003}$ pc), assuming the rest-frame period of the quasar variability traces the orbital period of the binary. This SMBHB candidate, discovered at the peak redshift for SMBH mergers, is in a physically stable configuration for a circumbinary accretion disk, and within the regime of GW-driven orbital decay. Our search with PS1 is a benchmark study for the exciting capabilities of LSST, which will have orders of magnitude larger survey power, and will potentially pinpoint the locations of thousands of SMBHBs in the variable night sky.
description: Published in ApJ Letters; matches published version
How Do I Pardon Thee?: The Effects of Relationship Type, Account Type, and Gender on Offence-Specific Forgiveness
Creators: name: Ridge, Robert D.
name: Hedges, Ariana
name: Mead, Brian G.
name: Busath, Gregory Lynn
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Forgiveness, ambivalent relationships, accounts, gender, transgressions, apologies

description: We employed a Bayesian analysis to compare offence-specific forgiveness in supportive versus ambivalent relationships. We also investigated offender accounts to assess their effect on forgiveness. Participants (283 total, 171 female) read a hypothetical scenario wherein an offender from a supportive or ambivalent relationship transgressed against them. The offender then offered a mitigating (i.e., concession or excuse) or an aggravating (i.e., justification or refusal) account for their behaviour. As predicted, an ambivalent offender received less forgiveness than a supportive offender, and mitigating accounts produced more forgiveness than aggravating accounts. These results suggest that the positive aspects of an ambivalent relationship are not substantial enough to negate the negative aspects of the relationship, which results in less forgiveness being offered to an offender, independent of the type of account offered for the offense.
An Efficient Strategy for the Synthesis of α,α′-cis and trans-Disubstituted Medium Ring Ethers
Creators: name: Crimmins, Michael T.
name: Emmitte, Kyle A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: An asymmetric alkylation-ring-closing metathesis strat-egy was developed for the construction of a,a'-disubstituted medi-um ring ethers. The approach features an asymmetric alkylation of highly functionalized a-alkoxy acyl oxazolidinones followed by ring closure effected by Grubbs' ruthenium catalyst. The relation-ship between diene conformation and the rate of ring-closure was examined. Medium ring ethers are a common structural feature of many ladder ether marine toxins, as well as simpler me-tabolites from Laurencia species. This diverse collection of natural products often contains seven, eight, and nine membered ring ethers. 1 The challenge of efficient con-struction of medium ring ethers has led to the develop-ment of numerous strategies for their synthesis. 2-5 The vast majority of these approaches have focused on the a,a'-cis-disubstitution pattern rather than a,a'-trans-di-substituted medium ring ethers, despite their similar fre-quency of occurrence. trans-Isoprelaurefucin (1), 6 isolau-refucin methyl ether (2), 7 chlorofucin (3), 8 bromofucin (4), 9 isolaureatin (5), 10 and obtusenyne (6), 8 for example, all contain a,a'-trans-disubstituted medium ring ethers (Figure 1). Murai's synthesis of obtusenyne (6) 11 and our own recent syntheses of prelaureatin and laurallene 12 con-stitute the only known syntheses of medium ring ether natural products with the a,a'-trans-disubstitution ar-rangement. The investigation of a versatile, general strat-egy for the synthesis of both a,a'-cis and a,a'-trans-disubstituted medium ring ethers is described here. We recently published a total synthesis of the marine nat-ural product (+)-laurencin (9), in which the key steps were an asymmetric alkylation of the sodium enolate of substi-tuted acyl oxazolidinone 7, followed by ring-closing met-athesis of the resultant diene to give cyclic ether 8 (Scheme 1). 2 Previous work in our laboratory has demon-strated that an asymmetric aldol-ring-closing metathesis strategy for the assembly of medium ring ethers was equally adaptable to both the a,a'-cis and a,a'-trans-di-substituted medium ring ethers. 3,12 The asymmetric alky-lation-ring-closing metathesis approach to cyclic ethers also offered the potential for a similar adaptable strategy.
Additional file 5 of Collaborative model of care between Orthopaedics and allied healthcare professionals in knee osteoarthritis (CONNACT): study protocol for an effectiveness-implementation hybrid randomized control trial
Creators: name: Tan, Bryan Yijia
name: Pereira, Michelle Jessica
name: Su-Yin Yang
name: Hunter, David J.
name: Soren Thorgaard Skou
name: Thumboo, Julian
name: Car, Josip
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Neuroscience
Biotechnology
Science Policy

description: Appendix 5 – SPIRIT checklist. (DOC 124 kb)
Economic hardship and sexually transmitted diseases in Haiti's rural Artibonite Valley.
Creators: name: Lucet, Catherine
name: Roberfroid, Dominique
name: Caliendo, Angela
name: Fitzgerald, Daniel W.
name: Fitzgerald, Jennifer W.
name: Behets, Frieda
name: Kuykens, Luc
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: A study was conducted to determine the prevalence rate and risk factors for sexually transmitted diseases (STDs) in Haiti's rural Artibonite Valley. Women attending antenatal services at Hospital Albert Schweitzer from October to December 1996 were tested for gonorrhea, chlamydia, trichomonas, syphilis, and human immunodeficiency virus (HIV). Of the 476 women tested, 121 (25.4%) had trichomonas, 11/475 (2.3%) had gonorrhea, 51/475 (10.7%) had chlamydia, 32/474 (6.8%) were seropositive for syphilis, 20/469 (4.3%) were seropositive for HIV, and 191 (40.1%) had at least one STD. Nearly 30% of the women reported having entered a sexual relationship out of economic necessity and had increased odds of HIV infection, Odds Ratio (OR) 6.3 (P < 0.001). We postulate that due to recent economic hardship in rural Haiti, women are entering into sexual relationships out of economic necessity and that this trend is contributing to the growing HIV epidemic. We recommend STD prevention and development programs that target young people and economically disadvantaged women.
Construction and properties of a topological index for periodically driven time-reversal invariant 2D crystals
Creators: name: Carpentier, David
name: Delplace, Pierre
name: Fruchart, Michel
name: Gawędzki, Krzysztof
name: Tauber, Clément
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present mathematical details of the construction of a topological invariant for periodically driven two-dimensional lattice systems with time-reversal symmetry and quasienergy gaps, which was proposed recently by some of us. The invariant is represented by a gap-dependent $\,\mathbb Z_2$-valued index that is simply related to the Kane-Mele invariants of quasienergy bands but contains an extra information. As a byproduct, we prove new expressions for the two-dimensional Kane-Mele invariant relating the latter to Wess-Zumino amplitudes and the boundary gauge anomaly.
description: published version ; 56 pages, 15 figures
Additional file 3 of Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein predicts poor prognosis in urothelial carcinoma
Creators: name: Liang, Peir-In
name: Lai, Hong-Yue
name: Chan, Ti-Chun
name: Li, Wei-Ming
name: Hsing, Chung-Hsi
name: Huang, Steven K.
name: Hsieh, Kun-Lin
name: Tseng, Wen-Hsin
name: Chen, Tzu-Ju
name: Li, Wan-Shan
name: Chen, Huan-Da
name: Kuo, Yu-Hsuan
name: Li, Chien-Feng
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3: Figs. S1-S7. Immunoblot Gel Raw data.
Una galleria delle Calunnie di Apelle. Fonti iconografiche e testuali (1408-1875)
Creators: name: Agnoletto Sara
Publisher: name: La Rivista di Engramma
Year: 2005
Subjects: Calumny of Apelles
Lucian

description: Gallery dedicated to the iconographic and textual sources of Lucian’s Calumny of Apelles of Luciano from 1408 to 1875.
Repositioning Individuals for Reading Competence: A Key Focus of the Smart Green Schools Initiative of Enugu State Government, Nigeria
Creators: name: Felicia, Nnenna Ene
Publisher: name: GO JOURNAL
Year: 2024
Subjects: Repositioning, reading competence, initiative, smart green school

description: This paper extols the Smart School initiative of the Enugu State government and the ultimate plan to launch the schools into the 4th industrial revolution. It points out that reading should occupy a pivotal place in the smart school curriculum. Reading involves an interaction between the reader and the printed text. That is to say that reading entails looking at the printed text to make meaning out of it. The journey of ‘learning to read’ begins in the basic or primary schools. The goal of reading instruction at the primary level is that every child should be functionally literate, able to communicate well, read and write with clear understanding, and utilize efficient problem-solving life skills. So, a solid foundation must be laid for reading competence among the pupils of the smart schools to equip them for the demands and tasks of the 4th Industrial Revolution. This is because reading failure in the past has led to educational failure as well as general underdevelopment.  This paper therefore argues that from the commencement of the smart schools, adequate attention must be paid to reading instruction, quality of personnel involved, processes of delivery, and product to reposition the individuals for higher reading achievement.
Jangan Khianati Guru
Creators: name: Zustiyantoro, Dhoni
Publisher: name: figshare
Year: 2022
Subjects: subject: 160506 Education Policy
subject: FOS: Political science
subject: 130313 Teacher Education and Professional Development of Educators
subject: FOS: Educational sciences

description: SECARA mengejutkan, Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi memasukkan Rancangan Undang-Undang Sistem Pendidikan Nasional (RUU Sisdiknas) ke dalam Program Legislasi Nasional (Prolegnas) 2022 kepada Dewan Perwakilan Rakyat. Beberapa hari ini, RUU Sisdiknas disorot oleh sejumlah pakar pendidikan karena sejumlah pasalnya dinilai kontroversial. Namun Kemdikbudristek berpendapat sebaliknya. Jika tak melibatkan ahli eksternal dan melalui uji publik yang ketat, RUU Sisdiknas berpotensi salah arah dan mengkhianati guru yang telah mengabdi untuk pendidikan di Tanah Air.
title: Wertekonflikte in der Nutzung sozialer Medien zur Vernetzung ungebundener HelferInnen in Krisensituationen – Ein Value-Sensitive Design Ansatz
Creators: name: Riebe, Thea
name: Langer, Amanda
name: Kaufhold, Marc-André
name: Kretschmer, Nina Katharina
name: Reuter, Christian
Publisher: name: Gesellschaft für Informatik e.V
Year: 2022

description: Bereits während des Hochwassers in Mitteleuropa 2013 und der Flüchtlingskrise in Europa ab 2015 wurde deutlich, dass freiwillige HelferInnen die Bewältigung von Krisensituationen unterstützen. Durch die vermehrte Koordination der Helfenden, auch unter Einsatz sozialer Medien, kommt es zunehmend zu Konflikten zwischen den teilweise kollidierenden Erwartungshaltungen periodisierter Werte der eingebundenen Akteure. Die Entwicklung von Kollaborationswerkzeugen mit Hilfe der Methode des Value-Sensitive Designs kann bereits im Vorfeld solche Konflikte aufzeigen und gezielt verhindern oder moderieren. Dazu wurde in einer Fallstudie anhand des Hochwassers 2013 induktiv abgeleitet, welche Werte und Erwartungen die unterschiedlichen Stakeholder haben, und welche Konflikte sich daraus im Hinblick auf die Anforderungen ergeben. Diese Studie zeigt insbesondere die Konfliktpotenziale für freiwillige HelferInnen in sozialen Medien in Bezug auf den Schutz der Privatsphäre und vor Diskriminierung auf und leistet damit einen Beitrag für die Konflikt-Optimierung und Akzeptanzsteigerung des Einsatzes sozialer Medien im Katastrophenschutz.
RECRUDESCENCE IN ARTESUNATE-TREATED PATIENTS WITH FALCIPARUM MALARIA IS DEPENDENT ON PARASITE BURDEN NOT ON PARASITE FACTORS
Creators: name: Udomsangpetch, Rachanee
name: Wilairatana, Polrat
name: Rattanasinganchan, Panthip
name: Meshnick, Steven R
name: Emery, Kathryn
name: Pickard, Amy L
name: Low, Jonathan
name: Looareesuwan, Sornchai
name: Ittarat, Wanida
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Artemisinin derivatives are first-line antimalarial drugs in Thailand. No firm evidence of clinically relevant artemisinin resistance exists. When used as monotherapy, artesunate has been associated with a high treatment failure (recrudescence) rate, which could be due to low-level artemisinin resistance. To understand the causes of recrudescence, we retrospectively studied a cohort of 104 malaria patients treated with artesunate monotherapy, 32 of whom recrudesced. There was no difference in in vitro artesunate sensitivities between 6 nonrecrudescent isolates and 16 paired
admission and recrudescent isolates. Paired admission and recrudescent isolates from 10 patients were genotyped; only
3 had pfmdr1 mutations. Patients with admission parasitemias >10,000 per µl had a 9-fold higher likelihood of recrudescence
(adjusted odds ratio) compared with patients with lower parasitemias. This study suggests (1) recrudescence
after treatment with artesunate is not the result of inherent parasite resistance, and (2) admission parasitemia may be
useful in choosing therapeutic options.
The Definition-Dependent Nature of Myopia Prevalence: A Nationwide Study of 1.5 Million Adolescents
Creators: name: Nitzan, Itay
name: Akavian, Inbal
name: Einan-Lifshitz, Adi
name: Shemer, Asaf
name: Afek, Arnon
name: Peled, Alon
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Space Science
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Marine Biology
Science Policy

description: The application of myopia definition varies considerably within the literature. The purpose of this study was to examine the relationship between different myopia and high myopia definitions and resultant prevalence estimates. A population-based cross-sectional study of 1,588,508 Israeli adolescents assessed for medical fitness before mandatory military service at the age of 17 years between 1993 through 2015. Participants underwent non-cycloplegic autorefraction. Nine definitions of myopia and seven definitions of high myopia were examined. Prevalence estimates for each definition were calculated and compared with the reference definition (right eye spherical equivalent (SE)≤-0.50D and ≤-6.00D for myopia and high myopia, respectively), to yield a rate ratio (RR) across definitions. Applying the right eye SE≤-0.50D reference definition yielded 31.0% myopia prevalence. While some definitions resulted in similar prevalence estimates, using the right eye SE of ≤-0.75D; ≤-1.00D or least minus meridian of ≤-0.75D definitions yielded 28.8%, 26.3%, and 26.9% myopia prevalence, respectively, which corresponded to a 7.1%, 15.1% and 13.4% reduction in myopia RR, respectively. The prevalence of high myopia demonstrated considerable alternations, with a 1.7-fold increase in prevalence for the narrower threshold of SE≤-5.00D compared with SE≤-6.00D reference definition (4.2% and 2.4%, respectively). The prevalence of myopia and especially high myopia varies between frequently applied definitions, considering diverse thresholds, eye lateralization, and spherical vs. astigmatic refractive components. This variability highlights the pressing need for standardization of myopia definition in ophthalmic research. The results of this study provide crude estimates of a “conversion rate” across data, allowing comparisons between studies that utilize different myopia definitions.
Case study n° 1: Risk of loss of tourism attractiveness due to climate change in the western Mediterranean (D4.2.1, factsheet in Spanish with an English summary)
Creators: name: Gabriel, Jordà
name: Agulles Miguel
name: Camilo, Melo-Aguilar
Publisher: name: Zenodo
Year: 2023

description: This UNCHAIN deliverable presents a fact sheet in Spanish with an English summary describing the main outcomes of the case study on the risk of loss of tourism attractiveness due to climate change in the Spanish Mediterranean destinations.
description: Support was provided by the Spanish Ministry of Science and Innovation through the grant PCI2019-103680 funded by MCIN/AEI/ 10.13039/501100011033 and by the European Union.
Saddle point formulations for a class of nonlinear boundary value problems
Creators: name: Cojocaru, Marianna
Publisher: name: Zenodo
Year: 2024

description: A class of boundary value problems governed by two subdifferential inclusions is considered. In the present paper we study the weak solvability by means of the saddle point theory. The boundary value problems under consideration are nonlinear problems arising from electricity and elasticity.
HEMATOLOGIC AND CLINICAL INDICES OF MALARIA IN A SEMI-IMMUNE POPULATION OF WESTERN THAILAND
Creators: name: Meshnick, Steven R
name: Gasser, Robert A
name: Miller, R Scott
name: Laoboonchai, Anintita
name: Buathong, Nilawan
name: Chuanak, Niphon
name: Yingyuen, Kritsanai
name: Erhart, Laura M
name: Wongsrichanalai, Chansuda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: This study examines hematologic profiles of persons with acute Plasmodium falciparum or P. vivax
infection in Maesod on Thailand’s western border with Myanmar compared with febrile, non-parasitemic persons also
reporting to malaria clinics. Nine hundred seventy-nine subjects were malaria-negative, 414 were infected with P.
falciparum, and 646 were infected with P. vivax. Persons with patent parasitemia tended to have significantly lower white
blood cell, red blood cell, platelet, and hemoglobin levels than those who were malaria-negative. For the first time, a
parallel trend in thrombocytopenia with parasitemia was found to be associated with both P. falciparum, and P. vivax
infection. Using logistic regression, persons with platelet counts < 150,000/µL were 12−15 times more likely to have
malaria than persons with platelet counts ≥ 150,000/µL. This study supplements previous literature on the hematologic
effects of malaria and helps define those alterations for a semi-immune population. Thrombocytopenia is identified as
a key indicator of malaria in these febrile patients.
Distributed Ledger Technologies - Past Present and Future
Creators: name: O'hEocha, Aonghus
Publisher: name: Zenodo
Year: 2020
Subjects: open finance
blockchain
Distributed Ledger Technologies

description: Slides for the Open Scholarship Cafe on 2 July 2020 by Aonghus O'hEocha . The topic was part of the event "Open Fintech, blockchain and cryptocurrencies - The future of Open Finance" on 2 July 2020 which was organised by the Open Scholarship Community Galway (OSCG). The structure of the talk was: Blockchain Definition, Origins & Technology Trends & use cases Distributed Ledger Technologies (DLT) - A Contraceptive to Corruption? The talk can be viewed at https://nuigalway.mediaspace.kaltura.com/media/Open+Scholarship+CafeA+Open+Finance+%282+July+2020%29/1_l83dc24f/121659351. A related blog post can be found at http://osc-galway.ie/os-cafe-open-finances/.
Long-Term Burden of Pain and Reduced Visual Acuity after Gunshot Wounds to the Orbit
Creators: name: Meer, Elana
name: Nguyen, Brian J.
name: Bautista, Sana
name: McGeehan, Brendan
name: Maguire, Maureen G.
name: Briceño, César A.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer
subject: Science Policy

description: To characterize the clinical presentation, surgical management, long-term complications and outcomes of Gunshot Wounds(GSW) to the orbit. An extended case series with retrospective chart-review was conducted on all cases (1985–2020) of traumatic ocular injuries secondary to GSWs at an academic institution with a level 1 trauma center. Predictors included demographic information, clinical and radiologic examination findings, and surgical intervention at time of presentation. Outcomes included long-term lid malposition, visual acuity, pain, and secondary surgery. Descriptive statistics and tests of association were performed, including Fishers exact tests for categorical data, Kruskal-Wallis rank sum tests, analysis of variance, and, in the case of repeated measures, generalized estimating equations. 88 patients with GSW involving the orbit were included with average age of 32.6 years (sd = 15.7). Patients were 85.2% male, 75% African-American, 25.0% Caucasian, and 5.7% Hispanic. Median follow up was 43.3 months (4.6, 136.4). The injuries at presentation were 53.4% intracranial, 21.6% open globe, 80.7% orbital fracture, 89.8% lid laceration. Visual acuity did not significantly improve over time. Long-term complications included abnormal lid or globe position in 26.1% of patients, reduced visual acuity in 55.2%, and persistent pain in 50.6%. To our knowledge, this represents the first and largest clinical epidemiologic study with insight into the clinical presentation, surgical intervention, and long-term outcomes of GSW to the orbit. The results demonstrate a long-term burden of persistent pain and reduced visual acuity in patients who suffer from GSW to the globe and orbit. This study may guide patient management and communications.
title: Large-scale dimensionality reduction using perturbation theory and singular vectors
Creators: name: Afshar, Majid
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: Massive volumes of high-dimensional data have become pervasive, with the number of features significantly exceeding the number of samples in many applications. This has resulted in a bottleneck for data mining applications and amplified the computational burden of machine learning algorithms that perform classification or pattern recognition. Dimensionality reduction can handle this problem in two ways, i.e. feature selection (FS) and feature extraction. In this thesis, we focus on FS, because, in many applications like bioinformatics, the domain experts need to validate a set of original features to corroborate the hypothesis of the prediction models. In processing the high-dimensional data, FS mainly involves detecting a limited number of important features among tens/hundreds of thousands of irrelevant and redundant features. We start with filtering the irrelevant features using our proposed Sparse Least Squares (SLS) method, where a score is assigned to each feature, and the low-scoring features are removed using a soft threshold. To demonstrate the effectiveness of SLS, we used it to augment the well-known FS methods, thereby achieving substantially reduced running times while improving or at least maintaining the prediction accuracy of the models. We developed a linear FS method (DRPT) which, upon data reduction by SLS, clusters the reduced data using the perturbation theory to detect correlations between the remaining features. Important features are ultimately selected from each cluster, discarding the redundant features. To extend the clustering applicability in grouping the redundant features, we proposed a new Singular Vectors FS (SVFS) method that is capable of both removing the irrelevant features and effectively clustering the remaining features. As such, the features in each cluster solely exhibit inner correlations with each other. The independently selected important features from different clusters comprise the final rank. Devising thresholds for filtering irrelevant and redundant features has facilitated the adaptability of our model to the particular needs of various applications. A comprehensive evaluation based on benchmark biological and image datasets shows the superiority of our proposed methods compared to the state-of-the-art FS methods in terms of classification accuracy, running time, and memory usage.
Melting conditions beneath the Newer Volcanics Province from probabilistic inversions
Creators: name: Vaughan-Taylor, Kelly
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The Newer Volcanics Province (NVP) represents mainland Australia’s youngest intraplate volcanism. Despite past studies, the exact mechanism of magma generation is heavily debated, with the exact source composition and melting environments remaining unclear. Previous models of NVP magma genesis have tended to focus on either geochemical or geophysical arguments. In this work, we use an integrated approach using both geochemical and geophysical observations to explain mantle processes. Geochemical data from the NVP is screened to obtain a dataset containing <2 Ma samples that represent primitive melts from peridotitic sources. A newprobabilistic inversion method is applied to the samples in conjunction with a recently developed mantle melting model to evaluate the melting conditions in the mantle. A separate geophysical model of the present-day thermochemical structure of the lithosphere and sublithospheric upper mantle is created by jointly inverting available seismic datasets. The results from the geochemical and the geophysical models suggest the presence of a thin, hot lithosphere. Furthermore, findings indicate the source is relatively depleted in all major elements except FeO but enriched in rare earth elements. The source is also suggested to have developed this signature due to a substantial input from the sub-continental lithosphere mantle.
A Refined Analysis of the Personality of the Surgical Workforce
Creators: name: Van Der Vorst, Joost R.
name: Sier, Vincent
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Medicine and Health Sciences
subject: Psychology
subject: FOS: Psychology
subject: Big Five
subject: Five-factor model
subject: Surgical personality

description: A Refined Analysis of the Personality of the Surgical Workforce. An initiative by the Surgical Personality Research (SUPER) group. Contact: www.surgicalpersonality.com.
Dichroism as a probe for parity-breaking phases of spin-orbit coupled metals
Creators: name: Norman, M. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Recently, a general formalism was presented for gyrotropic, ferroelectric, and multipolar order in spin-orbit coupled metals induced by spin-spin interactions. Here, I point out that the resulting order parameters are equivalent to expectation values of operators that determine natural circular dichroic signals in optical and x-ray absorption. Some general properties of these operator equivalents and the resulting dichroisms are mentioned, and I list several material examples in this connection, including Weyl semimetals. The particular case of the tensor order in the pyrochlore superconductor Cd2Re2O7 is treated in more detail, including calculations of the x-ray absorption and circular dichroism at the O K edge.
description: v3 is a significant extension of the previous version, including a new table and a figure presenting ab initio results on Cd2Re2O7
Additional file 1 of Evolutionary engineering of Lactobacillus bulgaricus reduces enzyme usage and enhances conversion of lignocellulosics to D-lactic acid by simultaneous saccharification and fermentation
Creators: name: J. Vishnu Prasad
name: Tridweep K. Sahoo
name: S. Naveen
name: Jayaraman, Guhan
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. Comparison of reported titer and yield of D-LA produced from lignocellulosics in literature and current work. Fig S1. Growth profile of L. bulgaricus WT on 30 g/L glucose at 37 °C in MRS media of a) 6 pH b) 5.5 pH. Fig S2. Growth profile of L. bulgaricus WT in LCB hydrolysate (SHF) at 37 °C and pH 5.5. Fig S3. Effect of temperature on enzymatic cellulose hydrolysis with 10% (w/v) solid loading using 5 FPU/gLCB at pH 5.5. Fig. S4. Tukey Simultaneous 95% Confidence Intervals –of one way ANOVA comparing the effect of temperature on enzymatic cellulosic hydrolysis with 10% (w/v) solid loading using at pH 5.5 at enzyme loadings of a) 5 FPU/gLCB and b) 15 FPU/gLCB. Fig S5. Effect of Cellobiose on cellulose hydrolysis with 10% (w/v) solid loading at pH 5.5 and 15 FPU/gLCB. Time course profile of (a) net cellobiose accumulation (b) percentage cellulose conversion. Fig S6. Effect of glucose removal on enzymatic cellulose hydrolysis with different enzyme loadings. Fig. S7. Growth profile of L. bulgaricus WT on 30 g/L glucose at in MRS media of pH 5.5 at a) 40 °C and b) 42 °C. Fig. S8. Growth profile of L. bulgaricus ET45 at 45 °C and pH 5.5 in a) 30 g/L glucose b) lignocellulosic hydrolysate containing 30 g/L glucose (SHF). Fig S9. Production of D-LA in batch SSF at pH 5.5 with 5% (w/v) solid loading by a) L. bulgaricus ET45 at 5 FPU/gLCB and 45 °C (b) L. bulgaricus ET45 at 3 FPU/gLCB and 45 °C (c) L. bulgaricus WT at 5 FPU/gLCB and 37 °C. Values are mean ± SD (n = 3).
Antihypertensive Use and the Risk of Cataract in Patients with Hypertension: A Nationwide Case-control Study
Creators: name: Yang, Hye Lim
name: Byun, Seong Jun
name: Park, Sewon
name: Lee, Sung Hoon
name: Park, Sang Jun
name: Jung, Sun-Young
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: This study aims to investigate the association between antihypertensive use and the risk of cataract in a matched case-control study. We analysed the Korean National Health Insurance Service-Health Screening Cohort database from 2002 to 2013. We defined ‘cases’ as patients prescribed antihypertensives and underwent their first eye cataract surgery between 2010 and 2013. ‘Controls’ were patients prescribed antihypertensives and no history of cataract surgery or diagnosis between 2002 and 2013. Four controls were matched to each case by several variables. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated for cataract risk using a conditional logistic regression model after adjustment. The analyses comprised 12,166 cases and 48,664 controls. The adjusted ORs for cataracts were 1.18 (95% CI: 1.12–1.24) in thiazide diuretics, 1.12 (95% CI: 1.07–1.18) in beta-blockers, 0.94 (95% CI: 0.90–1.00) in calcium channel blockers, 1.22 (95% CI: 1.14–1.30) in angiotensin-converting enzyme (ACE) inhibitors, and 0.97 (95% CI: 0.91–1.03) in angiotensin II receptor blockers compared to ‘non-use’ of each antihypertensive. In a nationwide case-control study, the use of thiazide diuretics, beta-blockers, or ACE inhibitors do not represent minimal clinical important difference in the risk of cataract and the use of calcium channel blockers or angiotensin II receptor blockers is not associated with an increased risk of cataracts compared to non-use of each antihypertensive. Given the benefits of treating hypertension, such as the reduction in further complications, we suggest there is no need to change current clinical practice for antihypertensives.
Additional file 1 of Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein predicts poor prognosis in urothelial carcinoma
Creators: name: Liang, Peir-In
name: Lai, Hong-Yue
name: Chan, Ti-Chun
name: Li, Wei-Ming
name: Hsing, Chung-Hsi
name: Huang, Steven K.
name: Hsieh, Kun-Lin
name: Tseng, Wen-Hsin
name: Chen, Tzu-Ju
name: Li, Wan-Shan
name: Chen, Huan-Da
name: Kuo, Yu-Hsuan
name: Li, Chien-Feng
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Primary antibodies and dilution for immunohistochemistry and immunoblot analysis.