cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Electronic supplementary material from Timing of spring departure of long distance migrants correlates with previous year conditions at their breeding site
Creators: name: Amélineau, Françoise
name: Delbart, Nicolas
name: Schwemmer, Philipp
name: Marja, Riho
name: Fort, Jérôme
name: Garthe, Stefan
name: Elts, Jaanus
name: Delaporte, Philippe
name: Rousseau, Pierre
name: Duraffour, Françoise
name: Bocher, Pierrick
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Contains supplementary methods S1 and S2, figure S1, table S1
A real-time fine particulate matter monitor based on inertial size-separation and optical detection in a microchannel
Creators: name: Yuen, Leon Ching Fung
Publisher: name: University of British Columbia
Year: 2016

description: Exposure to fine particulate matter smaller than 2.5 μm in diameter (PM 2.5) is linked to increased mortality and morbidity. The real-time monitoring of PM 2.5 has important applications in indoor and outdoor air quality monitoring including occupational environments. However, commercially available real-time instruments are bulky and expensive, not suitable for personal exposure level monitoring. This thesis presents a real-time, miniaturized PM 2.5 monitor which consists of a microfluidic-based particle trapping impactor and a forward light scattering optical detector with a 3D-printed housing. The particle trapping impactor channel includes a 90° turn, where larger particles experience a greater inertial force and enter and become captured in the particle trapping region. The detector, positioned downstream from the separator, illuminates the sized particles with a focused laser beam and detects light scattered by the particles using a photodiode to obtain the particle count. The baseline geometry of the impactor is designed according to conventional impactor design methods and analytical calculations. The geometry is further optimized through an iterative process by simulating the flow velocity and particle behavior in the microchannel to obtain the sorting efficiency. The fabricated impactor channel is tested by transmitting particles from 0.5 to 3 µm through the device and is shown to have a 50% cut-off diameter of around 3 µm. The experimental sorting efficiency curve agrees with simulation-based predictions. The arrangement of the detection system is optimized based on Mie scattering intensity and ray tracing calculations. Inexpensive, commercially available components are selected by modeling the optical power of scattered light on the photodiode surface. The detector is tested in parallel with a commercial instrument and shows good correlation at 1 minute sampling interval for 2 µm particles. The measured pulse peak voltage and pulse width agree with the theoretical calculations. The integrated device requires a 10 minutes sampling time for a statistically significant measurement due to particle loss at the interface between the separator and detector. The experimental results demonstrate the potential of using microfluidics as a platform for a low-cost, real-time portable PM 2.5 sensor.
title: Reforming the United Nations : a study of the Secretary-General's High-level Panel on Threats, Challenges and Change
Creators: name: Fraser, Trudy
Publisher: name: University of St Andrews
publisherIdentifier: https://ror.org/02wn5qz54
publisherIdentifierScheme: ROR
Year: 2011

description: This thesis examines the UN’s existential crisis of efficacy following its ineffectiveness in Rwanda (1994), Srebrenica (1995), Kosovo (1999) and Iraq (2003). Specifically, this thesis examines the reform agenda initiated by Secretary-General Kofi Annan’s High-level panel on Threats, Challenges and Change (HLP). The work seeks to diagnose the HLP-initiated reform of the UN and apply that analysis to prescribe the optimal shape of future UN reform. The current work analyses three main areas of reform initiated by the HLP—Security Council, Human Rights Council and development activities. One of the key subplots of the reform agenda concerned the expansion of the definition of security to encompass non-traditional issues such human rights and the coherent system-wide delivery of development functions. I put forth two intertwined theses: 1. The effectiveness of reform increased directly with distance from the Security Council and the veto powers contained therein; 2. The effectiveness of reforms in development placated developing countries and reduced the impetus for meaningful Security Council reform. The changes brought about by these reforms fell into two categories—structural and normative. Structural change is Charter-based legalistic reform, while normative change alters the ideals to which the UN aspires. Ineffective normative change took place at the Security Council, while ineffective structural change took place at the Human Rights Council. Only at the development level was there structural and normative change where intent was matched with action. It should be no surprise that the HLP-initiated reform agenda brought about effective, pragmatic changes only in development. Having completed this analysis of the effectiveness of the HLP-reform agenda, I will conclude by prescribing ways in which the UN can optimally reform itself based on a theory of tragedy that suggests political action to be best pursued in a piecemeal, small-scale results oriented fashion. The methodology of this work will be based on textual analysis of primary UN and Member State documents, expert interviews with UN personnel, and observation of the UN reform process. The empirical findings from thus will be correlated against a theoretical review of the purpose and effectiveness of the UN, and the UN reform agenda. It is anticipated that the combined empirical and theoretical sections will work together to elucidate new ways forward concerning the current limitations, and potential way forward, for the UN reform process.
Four Generations, Higgs Physics, and the MSSM
Creators: name: Dawson, S.
name: Jaiswal, P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the effects of a fourth generation of chiral fermions within the MSSM. Such a model offers the possibility of having the lightest neutral Higgs boson significantly heavier than in the three generation MSSM. The model is highly constrained by precision electroweak data, along with Higgs searches at the Tevatron. In addition, the requirements of perturbative unitarity and direct searches for heavy quarks imply that the four generation MSSM is only consistent for tan beta ~ 1 and highly tuned 4th generation fermion masses.
description: References added and minor typographical errors corrected
Macroscopic traversable wormholes: minimum requirements
Creators: name: Kuhfittig, Peter K. F.
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: While wormholes are just as good a prediction of Einstein's theory as black holes, they are subject to severe restrictions from quantum field theory. To allow for the possibility of interstellar travel, a macroscopic wormhole would need to maintain sufficiently low radial tidal forces. It is proposed in this paper that the assumption of zero tidal forces, i.e., the limiting case, is sufficient for overcoming the restrictions from quantum field theory. The feasibility of this approach is subsequently discussed by (a) introducing the additional conditions needed to ensure that the radial tidal forces can indeed be sufficiently low and (b) by viewing traversable wormholes as emergent phenomena, thereby increasing the likelihood of their existence.
description: 14 pages, no figures
EXPORT ORIENTATION AND IMPORT SUBSTITUTION: EVALUATING POLICIES IN TRANSITIONING TO AN EXPORT-ORIENTED DEVELOPMENT MODEL
Creators: name: Madaminov, Abduvosidjon
name: Xolmuxamedova, Solixa
name: Nurullaeva, Samirabonu
name: Ramatova, Alina
name: Khaitkulieva, Kumush
Publisher: name: Zenodo
Year: 2025

description: This study analyzes two major industrial development strategies—import substitution (IS) and export-oriented (EO) growth—highlighting their relevance for developing economies, particularly Uzbekistan. While IS policies aimed to foster domestic industries by limiting foreign competition, they often led to inefficiency and economic stagnation. In contrast, EO strategies, as demonstrated by countries like South Korea and China, have proven more effective in promoting innovation, competitiveness, and global market integration.  The paper discusses systemic issues restricting Uzbekistan's shift to an EO model such as strong reliance on primary goods exports, poor quality infrastructure, low value-added exports, and skill mismatch. It also reviews the contribution of WTO in promoting trade liberalization and provides the policy steps that would enable Uzbekistan to deal with the existing challenges. These policies include investment in education and R&D, modernization of the logistics and component manufacturing infrastructure, facilitation of small and medium enterprise activity, and deregulation. With these steps, Uzbekistan will be able to move towards a more diversified, competitive nondomestic, and sustainable economy.
Spectrum of an oscillator with jumping frequency and the interference of partial susceptibilities
Creators: name: Dykman, M. I.
name: Khasin, M.
name: Portman, J.
name: Shaw, S. W.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study an underdamped oscillator with shot-noise frequency fluctuations. The oscillator spectrum is determined by the interference of the susceptibilities for different eigenfrequencies. Depending on the parameters, it has a fine structure or displays a single asymmetric peak. For nano-mechanical resonators with a fluctuating number of attached molecules, the spectrum is found in a simple analytical form. The results bear on various types of systems where the reciprocal correlation time of frequency fluctuations can be comparable to the typical frequency jumps.
Additional file 1: of Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma
Creators: name: Ma, Jie
name: Fu, Yong
name: Tu, Yao-yao
name: Liu, Ying
name: Tan, Yi-ran
name: Ju, Wu-tong
name: Pickering, Curtis
name: Myers, Jeffrey
name: Zhang, Zhi-yuan
name: Zhong, Lai-ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Table S1. Non-synonymous mutations (threshold of allele frequency of â Ľ10%) in the cancerous tissues from oral squamous cell carcinoma patients. (DOCX 22Â kb)
Additional file 8: of Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma
Creators: name: Ma, Jie
name: Fu, Yong
name: Tu, Yao-yao
name: Liu, Ying
name: Tan, Yi-ran
name: Ju, Wu-tong
name: Pickering, Curtis
name: Myers, Jeffrey
name: Zhang, Zhi-yuan
name: Zhong, Lai-ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Table S6. Correlation between NOTCH1 non-synonymous mutation and baseline characteristics in patients with oral squamous cell carcinoma. (DOCX 19Â kb)
Research Note on a Parabolic Heat-Balance Integral Method with Unspecified Exponent: An Entropy Generation Approach in Optimal Profile Determination
Creators: name: Hristov, Jordan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The heat-balance integral method of Goodman is studied with two simple 1-D heat conduction problems with prescribed temperature and flux boundary conditions. These classical problems with well known exact solutions enable to demonstrate the heat-balance integral method performance by a parabolic profile and the entropy generation minimization concept in definition of the appropriate profile exponent. The basic assumption generating the additional constraints needed to perform the solution is based on the requirement to minimize the difference in the local thermal entropy generation rates calculated by the approximate and the exact profile, respectively. This concept is easily applicable since the general concept has simple implementation of the condition requiring the thermal entropy generations calculated through both profiles to be the same at the boundary. The entropy minimization generation approach automatically generates the additional requirement which is deficient in the set of conditions defined by the heat-balance integral method concept.
description: 11 pages, 1 figure
title: Shell
title: Shell
Creators: name: Skinner, Harold Allen
Publisher: name: BSB - Bavarian State Library
Year: 2020
Subjects: subject: Weltkrieg [1914-1918]
subject: Militärtechnik
subject: Waffentechnik
subject: World War, 1914-1918
subject: Military engineering

description: A shell is a streamlined steel metal projectile, filled with a variety of explosive and chemical payloads, and detonated by an impact or time fuse. Delivered by complex systems to the point of impact, artillery shells were the greatest cause of death and injury on the Great War battlefield.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Characterisation of Long Baseline Calibrators at 2.3 GHz
Creators: name: Hungwe, F.
name: Ojha, R.
name: Booth, R. S.
name: Bietenholz, M. F.
name: Collioud, A.
name: Charlot, P.
name: Boboltz, D.
name: Fey, A. L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a detailed multi-epoch analysis of 31 potential southern hemisphere radio calibrators that were originally observed as part of a program to maintain the International Celestial Reference Frame (ICRF). At radio wavelengths, the primary calibrators are Active Galactic Nuclei (AGN), powerful radio emitters which exist at the centre of most galaxies. These are known to vary at all wavelengths at which they have been observed. By determining the amount of radio source structure and variability of these AGN, we determine their suitability as phase calibrators for long baseline radio interferometry at 2.3 GHz. For this purpose, we have used a set of complementary metrics to classify these 31 southern sources into five categories pertaining to their suitability as VLBI calibrators. We find that all of the sources in our sample would be good interferometric calibrators and almost ninety per cent would be very good calibrators.
description: 9 pages, 7 Figures, accepted MNRAS
On the Queueing Behavior of Random Codes over a Gilbert-Elliot Erasure Channel
Creators: name: Parag, Parimal
name: Chamberland, Jean-Francois
name: Pfister, Henry D.
name: Narayanan, Krishna R.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper considers the queueing performance of a system that transmits coded data over a time-varying erasure channel. In our model, the queue length and channel state together form a Markov chain that depends on the system parameters. This gives a framework that allows a rigorous analysis of the queue as a function of the code rate. Most prior work in this area either ignores block-length (e.g., fluid models) or assumes error-free communication using finite codes. This work enables one to determine when such assumptions provide good, or bad, approximations of true behavior. Moreover, it offers a new approach to optimize parameters and evaluate performance. This can be valuable for delay-sensitive systems that employ short block lengths.
description: 5 pages, 4 figures, conference
The heat-balance integral method by a parabolic profile with unspecified exponent: Analysis and Benchmark Exercises
Creators: name: Hristov, Jordan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The heat-balance integral method of Goodman has been thoroughly analyzed in the case of a parabolic profile with unspecified exponent depending on the boundary condition imposed. That the classical Good man's boundary conditions defining the time-dependent coefficients of the prescribed temperature profile do not work efficiently at the front of the thermal layers if the specific parabolic profile at issue is employed. Additional constraints based on physical assumption enhance the heat-balance integral method and form a robust algorithm defining the parabola exponent . The method has been compared by results provided by the Veinik's method that is by far different from the Good man's idea but also assume forma tion of thermal layer penetrating the heat body. The method has been demonstrated through detailed solutions of 4 1-D heat-conduction problems in Cartesian co-ordinates including a spherical problem (through change of vari ables) and over-specified boundary condition at the face of the thermal layer.
description: 22 pages
Transduction on Kadanoff Sand Pile Model Avalanches, Application to Wave Pattern Emergence
Creators: name: Perrot, Kévin
name: Rémila, Eric
Publisher: name: arXiv
Year: 2011
Subjects: subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences

description: Sand pile models are dynamical systems describing the evolution from $N$ stacked grains to a stable configuration. It uses local rules to depict grain moves and iterate it until reaching a fixed configuration from which no rule can be applied. The main interest of sand piles relies in their {\em Self Organized Criticality} (SOC), the property that a small perturbation | adding some sand grains | on a fixed configuration has uncontrolled consequences on the system, involving an arbitrary number of grain fall. Physicists L. Kadanoff {\em et al} inspire KSPM, a model presenting a sharp SOC behavior, extending the well known {\em Sand Pile Model}. In KSPM($D$), we start from a pile of $N$ stacked grains and apply the rule: $D-1$ grains can fall from column $i$ onto the $D-1$ adjacent columns to the right if the difference of height between columns $i$ and $i+1$ is greater or equal to $D$. This paper develops a formal background for the study of KSPM fixed points. This background, resumed in a finite state word transducer, is used to provide a plain formula for fixed points of KSPM(3).
description: 14 pages
ArgoNeuT and the Neutrino-Argon Charged Current Quasi-Elastic Cross Section
Creators: name: Spitz, Joshua
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: ArgoNeuT, a Liquid Argon Time Projection Chamber in the NuMI beamline at Fermilab, has recently collected thousands of neutrino and anti-neutrino events between 0.1 and 10 GeV. The experiment will, among other things, measure the cross section of the neutrino and anti-neutrino Charged Current Quasi-Elastic interaction and analyze the vertex activity associated with such events. These topics are discussed along with ArgoNeuT's automated reconstruction software, currently capable of fully reconstructing the muon and finding the event vertex in neutrino interactions.
description: 6 pages, 4 figures, presented at the International Nuclear Physics Conference, Vancouver, Canada, July 4-9, 2010, to be published in Journal of Physics: Conference Series (JPCS)
New insights into the phytochemical composition, enzyme inhibition and antioxidant properties of desert cotton (Aerva javanica (Bum.f) Shult. -Amaranthaceae)
Creators: name: Saleem, Hammad
name: Zengin, Gokhan
name: Khan, Kashif-Ur-Rehman
name: Ahmad, Irshad
name: Waqas, Muhammad
name: Mahomoodally, Fawzi M.
name: Rengasamy, Kannan R.R.
name: Zainol, Noorazwani
name: Abidin, Syafiq Asnawi Zainal
name: Ahemad, Nafees
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: This study sets out to probe into total bioactive contents, UHPLC-MS secondary metabolites profiling, antioxidant (DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum and metal chelating) and enzyme inhibitory (acetylcholinesterase- AChE, butyrylcholinesterase- BChE, α-amylase, α glucosidase, and tyrosinase) activities of methanol extract of Aerva javanica, also known as desert cotton or Kapok bush. Aerva javanica contains considerable phenolic (44.79 ± 3.12 mg GAE/g) and flavonoid (28.86 ± 0.12 mg QE/g) contents which tends to correlate with its significant antioxidant potential for ABTS, FRAP and CUPRAC assays with values of 101.41 ± 1.18, 124.10 ± 1.71 and 190.22 ± 5.70 mg TE/g, respectively. The UHPLC-MS analysis identified the presence of 45 phytochemicals belonging to six major groups: phenolic, flavonoids, lignin, terpenes, glycoside and alkaloid. Moreover, the plant extract also showed potent inhibitory action against AChE (3.73 ± 0.22 mg GALAE/g), BChE (3.31 ± 0.19 mg GALAE/g) and tyrosinase (126.05 ± 1.77 mg KAE/g). The observed results suggest A. javanica could be further explored as a natural source of bioactive compounds.
Multiple-length-scale elastic instability mimics parametric resonance of nonlinear oscillators
Creators: name: Brau, Fabian
name: Vandeparre, Hugues
name: Sabbah, Abbas
name: Poulard, Christophe
name: Boudaoud, Arezki
name: Damman, Pascal
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: Spatially confined rigid membranes reorganize their morphology in response to the imposed constraints. A crumpled elastic sheet presents a complex pattern of random folds focusing the deformation energy while compressing a membrane resting on a soft foundation creates a regular pattern of sinusoidal wrinkles with a broad distribution of energy. Here, we study the energy distribution for highly confined membranes and show the emergence of a new morphological instability triggered by a period-doubling bifurcation. A periodic self-organized focalization of the deformation energy is observed provided an up-down symmetry breaking, induced by the intrinsic nonlinearity of the elasticity equations, occurs. The physical model, exhibiting an analogy with parametric resonance in nonlinear oscillator, is a new theoretical toolkit to understand the morphology of various confined systems, such as coated materials or living tissues, e.g., wrinkled skin, internal structure of lungs, internal elastica of an artery, brain convolutions or formation of fingerprints. Moreover, it opens the way to new kind of microfabrication design of multiperiodic or chaotic (aperiodic) surface topography via self-organization.
description: Submitted for publication
Searching for Weak or Complex Magnetic Fields in Polarized Spectra of Rigel
Creators: name: Shultz, M.
name: Wade, G. A.
name: Neiner, C.
name: Manset, N.
name: Petit, V.
name: Grunhut1, J.
name: Guinan, E.
name: Hanes, D.
name: Collaboration, the MiMeS
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Seventy-eight high-resolution Stokes V, Q and U spectra of the B8Iae supergiant Rigel were obtained with the ESPaDOnS spectropolarimeter at CFHT and its clone NARVAL at TBL in the context of the Magnetism in Massive Stars (MiMeS) Large Program, in order to scrutinize this core-collapse supernova progenitor for evidence of weak and/or complex magnetic fields. In this paper we describe the reduction and analysis of the data, the constraints obtained on any photospheric magnetic field, and the variability of photospheric and wind lines.
description: IAUS272 - Active OB Stars: Structure, Evolution, Mass Loss and Critical Limits
An Inverse Stefan Problem Relevant to Boilover: Heat Balance Integral Solutions and Analysis
Creators: name: Hristov, Jordan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Stefan problems relevant to burning oil-water systems are formulated. Two moving boundary sub-problems are defined: burning liquid surface and formation of a distillation ("hot zone") layer beneath it. The basic model considers a heat transfer equation with internal heat generation due to radiation flux absorbed in the fuel depth. In verse Stefan problem corresponding to the first case solved by the heat balance integral method and dimensionless scaling of semi-analytical solutions are at issue.
description: 20 pages, 3 figures, 3 tables
Five Elementary Proofs of Goldbach Conjecture (Fixed)
Creators: name: Chavez, Danilo
Publisher: name: figshare
Year: 2022
Subjects: subject: 10101 Algebra and Number Theory
subject: FOS: Mathematics
subject: 10401 Applied Statistics
subject: Algebra
subject: Probability

description: In this present paper we will show you five elementary proofs of the Goldbach Conjecture based on probabilities.
Time evolution of the QED vacuum in a uniform electric Field: Complete analytic solution by spinorial decomposition
Creators: name: Bialynicki-Birula, Iwo
name: Rudnicki, Łukasz
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Exact analytical solutions are presented for the time evolution of the density of pairs produced in the QED vacuum by a time-independent, uniform electric field. The mathematical tool used here to describe the pair production is the Dirac-Heisenberg-Wigner function introduced before [Phys. Rev. D 44, 1825 (1991)]. The initial value problem for this function is solved by decomposing the solution into a product of spinors. The equations for spinors are much simpler and are solved analytically. These calculations are nonperturbative since pair production is due to quantum-mechanical tunneling and the explicit solutions clearly exhibit their nonanalytic behavior.
description: 6 pages, 1 figure
Additional file 1: of Shanghai cognitive intervention of mild cognitive impairment for delaying progress with longitudinal evaluation-a prospective, randomized controlled study (SIMPLE): rationale, design, and methodology
Creators: name: Lin, Yiqi
name: Li, Binyin
name: Tang, Huidong
name: Xu, Qun
name: Wu, Yuncheng
name: Cheng, Qi
name: Li, Chunbo
name: Xiao, Shifu
name: Shen, Lu
name: Tang, Weiguo
name: Yu, Hui
name: He, Naying
name: Lin, Huawei
name: Yan, Fuhua
name: Cao, Wenwei
name: Yang, Shilin
name: Liu, Ye
name: Zhao, Wei
name: Lu, Dong
name: Jiao, Bin
name: Xiao, Xuewen
name: Zhou, Lin
name: Chen, Shengdi
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Computational Biology

description: Description of neuropsychological battery. Here is the description of neuropsychological assessments used in in the SIMPLE study, including their versions, scores and clinical significance. (DOCX 35 kb)
Implicit solvent models and free energies of solvation in the context of protein folding
Creators: name: Cumberworth, Alexander Michael
Publisher: name: University of British Columbia
Year: 2016

description: Given the wide and fundamental roles proteins play in cells, as well as their potential medical and industrial applications, a detailed understanding of the relationships between sequence, structure, dynamics, and function is of critical importance. Molecular models are required to solve this problem, as well as models of the associated conformational spaces. One of the most challenging aspects of modeling these vast ensembles is the computer power required to carry out the requisite simulations. Reduced solvent models, and particularly a class referred to as implicit solvent models, have been developed extensively; however, they make many assumptions and approximations that are likely to affect accuracy. Here, several implicit solvent models commonly used for protein modeling are evaluated by comparing the expected changes in free energies of solvation upon folding ΔGsolv derived from micro--ms simulations of fast folding proteins to those given by the implicit solvent models. In the majority of cases, there is a significant and substantial difference between the ΔGsolv values calculated from the two approaches, with the implicit solvent models excessively favouring the folded state over the unfolded state. This could only be remedied by selecting values for the model parameters -- the internal dielectric constant for the polar term and the surface tension coefficient for the apolar term -- that were system specific or physically unrealistic.
Georgia Climate Information Portal: Coast
Creators: name: Gambill, Jill
Publisher: name: figshare
Year: 2022
Subjects: subject: Climate Science
subject: 40105 Climatology (excl. Climate Change Processes)
subject: FOS: Earth and related environmental sciences
subject: 50101 Ecological Impacts of Climate Change
subject: 50204 Environmental Impact Assessment
subject: 50205 Environmental Management
subject: Environmental Science

description: The goal of this portal—created by Georgians for Georgians—is to share information and resources that can help all of us answer two key questions: What does a changing climate mean for Georgia, and what can we do about it?
This page focuses on the question: how does climate change affect Georgia's coast?
Redistributing Power in Mississippi: The Reversal of Section 4 of the Voting Rights Act
Creators: name: Billngsley, Gloria J.
name: Sylvester, Murray
Publisher: name: figshare
Year: 2021
Subjects: subject: 160699 Political Science not elsewhere classified
subject: FOS: Political science

description: Recently, the U.S. Supreme Court declared Section 4 of the Voting Rights Act of 1965 unconstitutional, essentially defanging preclearance requirements of Section 5 and leaving racial and other previously disenfranchised minorities unprotected. Using social contract theory as the theoretical framework, empirical field study research was used to examine whether the Voting Rights Act has achieved the results in Mississippi that the Supreme Court’s decision to revoke Section 4 has assumed. Data were collected on race-specific voter registration and voting data, measures of vote discrimination, litigations and Mississippi legislative activity regarding voting rights. Findings indicate that the gap between minority and non-minority voter registration and voting has improved. However, other measures of vote discrimination show that Mississippi has a higher noncompliance rate than any of the other 1965 covered jurisdictions. These findings suggest that the decision in Shelby v. Holder may be premature, particularly as it relates to Mississippi. A Congressional remedy is needed to ensure that Black Mississippians have unfettered opportunities to exercise their Constitutional right to vote and sustain the gains in political power resulting from the protection afforded under Section 4 of the Voting Rights Act.
Additional file 11: of Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma
Creators: name: Ma, Jie
name: Fu, Yong
name: Tu, Yao-yao
name: Liu, Ying
name: Tan, Yi-ran
name: Ju, Wu-tong
name: Pickering, Curtis
name: Myers, Jeffrey
name: Zhang, Zhi-yuan
name: Zhong, Lai-ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Table S9. Correlation between CDH1 non-synonymous mutation and baseline characteristics in patients with oral squamous cell carcinoma. (DOCX 19Â kb)
Additional file 9: of Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma
Creators: name: Ma, Jie
name: Fu, Yong
name: Tu, Yao-yao
name: Liu, Ying
name: Tan, Yi-ran
name: Ju, Wu-tong
name: Pickering, Curtis
name: Myers, Jeffrey
name: Zhang, Zhi-yuan
name: Zhong, Lai-ping
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Table S7. Correlation between CAPS8 non-synonymous mutation and baseline characteristics in patients with oral squamous cell carcinoma. (DOCX 19Â kb)
A proper motion study of the Lupus clouds using VO tools
Creators: name: Martí, Belén López
name: Jiménez-Esteban, Francisco
name: Solano, Enrique
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Aims: By using kinematical information, we test the membership of the new Lupus candidate members proposed by the Cores to Disks (c2d) Spitzer Legacy Program program and by a complementary optical survey. We also investigate the relationship between the proper motions (pm) and other properties, in order to get some clues about their formation and early evolution. Methods: We compiled a list of members and possible members of Lupus 1, 3, and 4, together with all information on their spectral types, disks, and physical parameters. Using VO-tools, we cross-matched this list with the astrometric catalogues to get pm. Our final sample contains sources with magnitudes I<16mag and estimated masses >~0.1Msun. Results: According to the kinematic information, our sources can be divided into two main groups. The first one contains sources with higher pm in agreement with other Gould Belt populations and with spatial distribution, optical and near-infrared colours, and disk composition consistent with these objects belonging to the Lupus clouds. In the second group, sources have lower pm with random orientations, and they are mostly located outside the cloud cores, making their association with the Lupus complex more doubtful. We investigate the properties of the higher pm group, but cannot find any correlations with spatial location, binarity, the presence of a circumstellar disk, or with physical properties such as effective temperature, luminosity, mass, or age. Conclusions: We conclude that the lower pm group probably represents a background population or mixture of populations unrelated to the Lupus clouds. The higher pm group, on the other hand, has properties consistent with it being a genuine population of the Lupus star-forming region. More accurate pm and/or radial velocity information are required for a more detailed study of the kinematic properties of the Lupus stellar members.
description: Accepted in A&A
Truncation error analysis for diffusion schemes in boundary regions of unstructured meshes
Creators: name: Puneria, Varun Prakash
Publisher: name: University of British Columbia
Year: 2015

description: Accuracy of numerical solution is of paramount importance for any CFD simulation. The error in satisfying the continuous partial differential equations by their discrete form results in truncation error and it has a direct influence on discretization errors. Discretization error, which is the difference in the numerical solution and the exact solution to a CFD problem, is generally the largest source of numerical errors. Understanding the relationship between the discretization and truncation error is crucial for reducing numerical errors. Studies have been carried out to understand the truncation-discretization error relationship in the interior regions of a computational domain but fewer for the boundary regions. The effect of different solution reconstruction methods, face gradient averaging schemes and boundary condition implementation methods on boundary truncation error in specific and overall truncation and solution error are the subject of research for this thesis. To achieve the goals laid out, the error has to be quantified first and then tests performed to compare the schemes. The Poisson's equation is chosen as the model diffusion equation. The truncation error coefficients, analogous to the analytical coefficients of the spatial derivatives in Taylor series expansion of truncation error, are quantified using error metrics. The solution error calculation is made possible by a careful selection of exact solutions and their appropriate source terms for Poisson's equation. Analytic tests are performed on a family of topologically regular meshes to test and verify the theoretical implementation of different schemes and to eliminate schemes performing poorly from consideration for numerical tests. The numerical tests are performed on unstructured triangular, mixed and pure quad meshes to extend the accuracy assessment for general meshes. The results obtained from both the tests are utilized to arrive at schemes where the overall truncation error and discretization error can be minimized simultaneously.
A QUANTITATIVE ANALYSIS OF COMMON CHALLENGES FACED BY WOMEN PRISONERS IN THAI PRISONS
Creators: name: Veenunkarn Rujiprak
Publisher: name: National Research Council of Thailand
Year: 2021
Subjects: Women Prisoners
Prisons in Thailand
Problems in Prisons
Challenges

description: SOCIAL SCIENCE ASIA : Official Journal of National Research Council of Thailand in conjunction with Journal of Thai Justice System, 7, 3, 67-80
Additional file 1: of Ethanol locks for the prevention of catheter-related bloodstream infection: a meta-analysis of randomized control trials
Creators: name: Zhang, Peng
name: Lei, Jun-Hao
name: Su, Xin-Jun
name: Wang, Xing-Huan
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Reasons for the exclusion of 36 studies in the literature screening process. (DOCX 67 kb)
Fish-tail and vortex dynamics in Ni doped iron-pnictide BaFe{1.82}Ni_{0.18}As_2
Creators: name: Salem-Sugui, S.
name: Ghivelder, L.
name: Alvarenga, A. D.
name: Cohen, L. F.
name: Luo, Huiqian
name: Lu, Xingye
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the vortex-dynamics of a BaFe{1.82}Ni_{0.18}As_2 crystal with Tc = 8 K, by measuring flux-creep over the second magnetisation (or fish-tail) peak for both H//c-axis and H//ab planes. Magnetic relaxation data show an anomalously long initial stage of relaxation, lasting approximately10 minutes for H//c-axis and 2-3 min for H//ab, resembling a transient effect with a lower relaxation rate, which is followed by the usual log(time) relaxation. Interestingly, study of the relaxation rate R vs H for both stages of relaxation and for both field directions, are featureless over the field range associated with the fish-tail. The same trend was confirmed by plotting R vs T obtained from flux-creep data measured as a function of temperature for a fixed field (H//$c-axis). A plot of the activation energy U(M,T) calculated from the time relaxation of the magnetisation at a fixed field also shows a smooth behavior further supporting the view that the fish-tail peak is not associated with a crossover in vortex pinning regime within the collective pinning scenario.
description: 4 pages, 4 figures
Kinematically detected polar rings/disks in blue compact dwarf galaxies
Creators: name: Moiseev, Alexei
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Polar ring galaxies are systems with nearly orthogonally rotated components. We have found the gas on polar (or strongly inclined) orbits in two BCD galaxies using ionized gas velocity fields taken with a Fabry-Perot interferometer of the SAO RAS 6-m telescope. Our analysis shows that all ionized gas in Mrk 33 is concentrated in a compact disk (3 kpc in diameter) which rotates in the polar plane relative to the main stellar body. The gaseous disk in Mrk 370 has a more complex structure with a heavily warped innermost part. The presence of polar gaseous structures supports an idea that current the burst of star formation in these galaxies is due to the external gas accretion or merging. A possible fraction of polar structures among BCD galaxies seems to be very large (up to 10-15%)
description: to appear in the proceedings of the conference "A Universe of dwarf galaxies" (Lyon, June 14-18, 2010)
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Creators: name: Perera, Luke A
name: Preissler, Steffen
name: Zaccai, Nathan R
name: Prévost, Sylvain
name: Devos, Juliette M
name: Haertlein, Michael
name: Ron, David
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Humans
Nucleotidyltransferases
Heat-Shock Proteins
Membrane Proteins
Adenosine Monophosphate
Adenosine Triphosphate
Protein Processing, Post-Translational
Amino Acid Motifs
Dimerization
Biocatalysis

description: The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present crystallographic and solution structures of a deAMPylation Michaelis complex formed between mammalian AMPylated BiP and FICD. The latter, via its tetratricopeptide repeat domain, binds a surface that is specific to ATP-state Hsp70 chaperones, explaining the exquisite selectivity of FICD for BiP's ATP-bound conformation both when AMPylating and deAMPylating Thr518. The eukaryotic deAMPylation mechanism thus revealed, rationalises the role of the conserved Fic domain Glu234 as a gatekeeper residue that both inhibits AMPylation and facilitates hydrolytic deAMPylation catalysed by dimeric FICD. These findings point to a monomerisation-induced increase in Glu234 flexibility as the basis of an oligomeric state-dependent switch between FICD's antagonistic activities, despite a similar mode of engagement of its two substrates - unmodified and AMPylated BiP.
Feature analysis and in silico prediction of lower solubility proteins in three eukaryotic model systems
Creators: name: Chan, Gerard
Publisher: name: University of British Columbia
Year: 2015

description: Regulation of protein solubility, or the ability of proteins to remain soluble within the cell, is an important part of protein homeostasis. This is highlighted with the disruption of protein homeostasis and dysregulation of solubility being associated with various neurodegenerative diseases. Using quantitative mass spectrometry and computational analyses, we identify low solubility proteins under unstressed conditions in three eukaryotic model systems: yeast cells, human neuroblastoma cells, and mouse brain tissue. Using an internal reference, we account for protein abundance, and allow for the analysis of proteins based on their partitioning between the soluble and insoluble fractions, rather than purely on their abundance within the insoluble fraction. We identified several intrinsic traits such as length, disorder, abundance, molecular recognition features, and low complexity regions which are correlated with protein solubility. These features have been previously shown to be associated with protein-protein interactions. This suggests that, under unstressed conditions, lower solubility in proteins may be linked to functional aggregation, rather than aberrant aggregation. We then present two predictors which may be used to predict the in vivo solubility of proteins, built using the many traits examined in this work. The linear regression model is able to give estimates of protein solubility, although proteins near the threshold between low and normal solubility may be misclassified. The Support Vector Machine is able to reliably distinguish between low and high solubility proteins, but is unable to reliably distinguish low and normal solubility proteins. We have identified several traits that distinguish low solubility proteins from other proteins, as well as developed two models that are able to estimate the solubility of proteins.
Anytime parallel tempering
Creators: name: Marie D’Avigneau, Alix
name: Singh, Sumeetpal S.
name: Murray, Lawrence M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
Bayesian inference
Markov chain Monte Carlo (MCMC )
Parallel tempering
Anytime Monte Carlo
Approximate Bayesian computation (ABC )
Likelihood-free inference

description: Abstract: Developing efficient MCMC algorithms is indispensable in Bayesian inference. In parallel tempering, multiple interacting MCMC chains run to more efficiently explore the state space and improve performance. The multiple chains advance independently through local moves, and the performance enhancement steps are exchange moves, where the chains pause to exchange their current sample amongst each other. To accelerate the independent local moves, they may be performed simultaneously on multiple processors. Another problem is then encountered: depending on the MCMC implementation and inference problem, local moves can take a varying and random amount of time to complete. There may also be infrastructure-induced variations, such as competing jobs on the same processors, which arises in cloud computing. Before exchanges can occur, all chains must complete the local moves they are engaged in to avoid introducing a potentially substantial bias (Proposition 1). To solve this issue of randomly varying local move completion times in multi-processor parallel tempering, we adopt the Anytime Monte Carlo framework of (Murray, L. M., Singh, S., Jacob, P. E., and Lee, A.: Anytime Monte Carlo. arXiv preprintarXiv:1612.03319, (2016): we impose real-time deadlines on the parallel local moves and perform exchanges at these deadlines without any processor idling. We show our methodology for exchanges at real-time deadlines does not introduce a bias and leads to significant performance enhancements over the naïve approach of idling until every processor’s local moves complete. The methodology is then applied in an ABC setting, where an Anytime ABC parallel tempering algorithm is derived for the difficult task of estimating the parameters of a Lotka–Volterra predator-prey model, and similar efficiency enhancements are observed.