cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis
Creators: name: Alemayehu, Ermiyas
name: Fiseha, Temesgen
name: Bambo, Getachew Mesfin
name: Sahile Kebede, Samuel
name: Bisetegn, Habtye
name: Tilahun, Mihret
name: Debash, Habtu
name: Ebrahim, Hussen
name: Mohammed, Ousman
name: Belete, Melaku Ashagrie
name: Gedefie, Alemu
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Supplementary Material 1
Design and fabrication of diffractive atom chips for laser cooling and trapping
Creators: name: Cotter, J. P.
name: McGilligan, J. P.
name: Griffin, P. F.
name: Rabey, I. M.
name: Docherty, K.
name: Riis, E.
name: Arnold, A. S.
name: Hinds, E. A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: It has recently been shown that optical reflection gratings fabricated directly into an atom chip provide a simple and effective way to trap and cool substantial clouds of atoms [1,2]. In this article we describe how the gratings are designed and micro-fabricated and we characterise their optical properties, which determine their effectiveness as a cold atom source. We use simple scalar diffraction theory to understand how the morphology of the gratings determines the power in the diffracted beams.
ОСНОВНЫЕ ПОДХОДЫ В УПРАВЛЕНИИ ПРЕДПРИЯТИЕМ
Creators: name: ПУШКАРЁВ О.Н.
name: ЕВДОКИМОВ В.О.
Publisher: name: StudNet
Year: 2020
Subjects: SYSTEM APPROACH
PROCESS APPROACH
SITUATIONAL APPROACH
ENTERPRISE MANAGEMENT
СИСТЕМНЫЙ ПОДХОД
ПРОЦЕССНЫЙ ПОДХОД
СИТУАЦИОННЫЙ ПОДХОД
УПРАВЛЕНИЕ ПРЕДПРИЯТИЕМ

description: Данная статья посвящена рассмотрению трёх важнейших подходов в управлении предприятием: системный, процессный и ситуационный. Системный подход рассматривает организацию, как открытую систему. Процессный подход рассматривает функции управления как взаимосвязанный процесс. Ситуационный подхододин из самых распространенных подходов. В его основе лежит анализ внешних и внутренних факторов, вследствие которого выбирается оптимальный метод управления организацией.This article is devoted to the consideration of three major approaches to enterprise management: systemic, process and situational. A systematic approach considers the organization as an open system. The process approach considers management functions as an interconnected process. The situational approach is one of the most common approaches. It is based on an analysis of external and internal factors, as a result of which the optimal method of managing the organization is selected.
Construction of a traversable wormhole from a suitable embedding function
Creators: name: Rueda, A.
name: Ávalos, R.
name: Contreras, E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work, we construct a traversable wormhole by providing a suitable embedding function ensuring the fulfilling of the flaring--out condition. The solution contains free parameters that are reduced through the study of the acceptable conditions of a traversable wormhole. We compute both the quantifier of exotic matter and the quasi--normal modes through the $13^{th}$ order WKB as a function of the remaining free parameters. We obtain that the wormhole geometry can be sustained by a finite amount of exotic matter and seems to be stable under scalar perturbations.
Finiteness of $π_1$-sensitive Hofer-Zehnder capacity and equivariant loop space homology
Creators: name: Frauenfelder, Urs
name: Pajitnov, Andrei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Symplectic Geometry (math.SG)
subject: Algebraic Topology (math.AT)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53D05, 53D40, 55N91, 55P35, 57R17

description: We prove that if M is a closed, connected, oriented, rationally inessential manifold, then the Hofer-Zehnder capacity of the unit disk bundle of the cotangent bundle of M is finite.
description: 13 pages
Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood
Creators: name: Möllers, Tobias
name: Stocker, Hannah
name: Perna, Laura
name: Nabers, Andreas
name: Rujescu, Dan
name: Hartmann, Annette M.
name: Holleczek, Bernd
name: Schöttker, Ben
name: Gerwert, Klaus
name: Brenner, Hermann
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Background: To understand the potential for early intervention and prevention measures in Alzheimer’s disease, the association between risk factors and early pathological change needs to be assessed. Hence, the aim of this study was to determine whether risk factors of Alzheimer’s clinical syndrome (clinical AD), such as body mass index (BMI), are associated with Aβ misfolding in blood, a strong risk marker for AD among older adults. Methods: Information on risk factors and blood samples were collected at baseline in the ESTHER study, a population-based cohort study of older adults (age 50–75 years) in Germany. Aβ misfolding in blood plasma was analyzed using an immuno-infrared-sensor in a total of 872 participants in a nested case-control design among incident dementia cases and matched controls. Associations between risk factors and Aβ misfolding were assessed by multiple logistic regression. For comparison, the association between the risk factors and AD incidence during 17 years of follow-up was investigated in parallel among 5987 cohort participants. Results: An inverse association with Aβ misfolding was seen for BMI at age 50 based on reported weight history (aOR 0.64, 95% CI 0.43–0.96, p = 0.03). Similar but not statistically significant associations were seen for BMI at baseline (i.e., mean age 68) and at age 40. No statistically significant associations with Aβ misfolding were found for other risk factors, such as diabetes, smoking, and physical activity. On the other hand, low physical activity was associated with a significantly reduced risk of developing clinical AD compared to physical inactivity. Conclusions: Our results support that AD pathology may be detectable and associated with reduced weight even in middle adulthood, many years before clinical diagnosis of AD. Physical activity might reduce the risk of onset of AD symptoms.
Implications of the corporate food regime on small farmers in Bangladesh
Creators: name: Haque, Mohammed Ziaul
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis investigates the implications of the corporate food regime for small farmers in Bangladesh by using the conceptual framework of food regime analysis and a mixed methods approach to data collection. It argues that, although the corporate food regime has challenged the livelihood of small farmers, it also provides them with opportunities. A further contribution of this thesis is its argument that an economic access to food is not the sole determinant of food security, with other aspects of entitlement, such as political, social and legal, being equally important. Bangladesh has some unique features that make it ideal as a case study for investigating the implications of the corporate food regime, due to its three different geo-political identities during the three food regimes. This study therefore offers a much-required historical perspective on the implications of the present food regime for the small farmers in Bangladesh. At the same time, this research provides an opportunity to obtain an understanding of the fate of small farmers in a pragmatic and sustainable manner, due to the transitional nature of the agri-food system and economy of Bangladesh. The study concludes with the need to take a realistic and sustainable look at small farming, so that the members of this occupational group are not deprived of their right to reach the next stage of their development.
The effect of home visits as an additional recruitment step on the composition of the final sample : a cross-sectional analysis in two study centers of the German National Cohort (NAKO)
Creators: name: Krist, Lilian
name: Bedir, Ahmet
name: Fricke, Julia
name: Kluttig, Alexander
name: Mikolajczyk, Rafael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Background: Participation in epidemiologic studies has been declining over the last decades. In addition to postal invitations and phone calls, home visits can be conducted to increase participation. The aim of this study was therefore to evaluate the effects of home visits in terms of response increase and composition of the additionally recruited and final sample. Methods: In the framework of the German National Cohort (NAKO) recruitment process, two of 18 study centers, Halle (Saale) and Berlin-Center, performed home visits as additional recruitment step after postal invitation and reminders. Response increase was calculated and differences between participants recruited via home visits and standard recruitment were examined. Proportions are presented as percentages with 95%-confidence intervals. Results: In the general population in Halle, 21.3-22.8% participated after postal invitation and two reminders in the five assessed recruitment waves. The increase of the overall response was 2.8 percentage points (95%confidence interval: 1.9-4.0) for home visits compared to 2.4 percentage points (95%CI: 1.7-3.3) for alternatively sent third postal reminder. Participants recruited via home visits had similar characteristics to those recruited via standard recruitment. Among persons of Turkish descent in Berlin-Center site of the NAKO, home visits conducted by native speakers increased the participation of women, persons living together with their partner, were born in Turkey, had lower German language skills, lower-income, lower education, were more often smokers and reported more often diabetes and depression to a degree which changed overall estimates for this subsample. Conclusions: As an additional recruitment measure in the general population, home visits increased response only marginally, and the through home visits recruited participants did not differ from those already recruited. Among persons with migration background, home visits by a native speaker increased participation of persons not reached by the standard recruitment, but the effects of using a native speaker approach could not be separated from the effect of home visits.
Tuberculin anergy in a clinically normal population
Creators: name: Martin., Christopher Leon
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
A smoothness test for higher codimensions
Creators: name: Boehm, Janko
name: Frühbis-Krüger, Anne
Publisher: name: arXiv
Year: 2016
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14B05, 68W10, 13P10, 32S05

description: Based on an idea in Hironaka's proof of resolution of singularities, we present an algorithmic smoothness test for algebraic varieties. The test is inherently parallel and does not involve the calculation of codimension-sized minors of the Jacobian matrix of the variety. We also describe a hybrid method which combines the new method with the Jacobian criterion, thus making use of the strengths of both approaches. We have implemented all algorithms in the computer algebra system Singular, and compare the different approaches with respect to timings and memory usage. The test examples originate from questions in algebraic geometry, where the use of the Jacobian criterion is impractical due to the number and size of the minors involved.
description: 12 pages, 4 algorithms
Intersection Two-Vehicle Crash Scenario Specification for Automated Vehicle Safety Evaluation Using Sequence Analysis and Bayesian Networks
Creators: name: Song, Yu
name: Chitturi, Madhav V.
name: Noyce, David A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: This paper develops a test scenario specification procedure using crash sequence analysis and Bayesian network modeling. Intersection two-vehicle crash data was obtained from the 2016 to 2018 National Highway Traffic Safety Administration Crash Report Sampling System database. Vehicles involved in the crashes are specifically renumbered based on their initial positions and trajectories. Crash sequences are encoded to include detailed pre-crash events and concise collision events. Based on sequence patterns, the crashes are characterized as 55 types. A Bayesian network model is developed to depict the interrelationships among crash sequence types, crash outcomes, human factors, and environmental conditions. Scenarios are specified by querying the Bayesian network conditional probability tables. Distributions of operational design domain attributes - such as driver behavior, weather, lighting condition, intersection geometry, traffic control device - are specified based on conditions of sequence types. Also, distribution of sequence types is specified on specific crash outcomes or combinations of operational design domain attributes.
К ВОПРОСУ О КОРПОРАТИВНОМ ВОЛОНТЕРСТВЕ КРАСНОЯРСКОМ КРАЕ (НА ПРИМЕРЕ БЛАГОТВОРИТЕЛЬНОЙ ОРГАНИЗАЦИИ ФОНД «ЦЕНТР СОЦИАЛЬНЫХ ПРОГРАММ»)
Creators: name: САПРЫГИНА С.А.
name: ЗЕМЦОВА Ю.Е.
Publisher: name: StudNet
Year: 2020
Subjects: VOLUNTEERING
CORPORATE VOLUNTEERING
GRANT COMPETITION
PROGRAM
PROJECT
ВОЛОНТЕРСТВО
КОРПОРАТИВНОЕ ВОЛОНТЕРСТВО
ГРАНТОВЫЙ КОНКУРС
ПРОГРАММА
ПРОЕКТ

description: Статья посвящена изучению опыта организации деятельности корпоративных волонтеров, на примере Благотворительной организации Фонда «Центр социальных программ» Компании РУСАЛ. Раскрыта сущность корпоративного волонтерства в данной организации, его цели и методы работы с корпоративными волонтерами. Показан успешный опыт объединения ресурсов компаний Красноярска, с целью решения социальных вопросов города, через деятельность волонтеров. Так же представлены успешные практики реализованных проектов корпоративных волонтеров.The article examines the experience of activities corporate volunteers, for example Charity Fund "Center of social programs" RUSAL. The essence of corporate volunteering in this organization, its goals and methods of working with corporate volunteers are revealed. The successful experience of combining the resources of Krasnoyarsk companies with the purpose of solving social issues of The city through the activities of volunteers is shown. Successful practices of implemented projects of corporate volunteers are also presented.
Probing the magnetic field structure in Sgr A* on Black Hole Horizon Scales with Polarized Radiative Transfer Simulations
Creators: name: Gold, Roman
name: McKinney, Jonathan C.
name: Johnson, Michael D.
name: Doeleman, Sheperd S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Magnetic fields are believed to drive accretion and relativistic jets in black hole accretion systems, but the magnetic-field structure that controls these phenomena remains uncertain. We perform general relativistic (GR) polarized radiative transfer of time-dependent three-dimensional GR magnetohydrodynamical (MHD) simulations to model thermal synchrotron emission from the Galactic Center source Sagittarius A$^\ast$ (Sgr A*). We compare our results to new polarimetry measurements by the Event Horizon Telescope (EHT) and show how polarization in the visibility (Fourier) domain distinguishes and constrains accretion flow models with different magnetic field structures. These include models with small-scale fields in disks driven by the magnetorotational instability (MRI) as well as models with large-scale ordered fields in magnetically-arrested disks (MAD). We also consider different electron temperature and jet mass-loading prescriptions that control the brightness of the disk, funnel-wall jet, and Blandford-Znajek-driven funnel jet. Our comparisons between the simulations and observations favor models with ordered magnetic fields near the black hole event horizon in Sgr A*, although both disk- and jet-dominated emission can satisfactorily explain most of the current EHT data. We show that stronger model constraints should be possible with upcoming circular polarization and higher frequency ($349~{\rm GHz}$) measurements.
description: Submitted to ApJ, 20 pages, 19 figures, 1 table
Usable Security for an IoT OS: Integrating the Zoo of Embedded Crypto Components Below a Common API
Creators: name: Boeckmann, Lena
name: Kietzmann, Peter
name: Lanzieri, Leandro
name: Schmidt, Thomas
name: Wählisch, Matthias
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences
subject: D.4.6; B.8.2; D.2.8

description: IoT devices differ widely in crypto-supporting hardware, ranging from no hardware support to powerful accelerators supporting numerous of operations including protected key storage. An operating system should provide uniform access to these heterogeneous hardware features, which is a particular challenge in the resource constrained IoT. Effective security is tied to the usability of cryptographic interfaces. A thoughtful API design is challenging, and it is beneficial to re-use such an interface and to share the knowledge of programming embedded security widely. In this paper, we integrate an emerging cryptographic interface into usable system-level calls for the IoT operating system RIOT, which runs on more than 240 platforms. This interface supports ID-based key handling to access key material in protected storage without exposing it to anyone. Our design foresees hardware acceleration on all available variants; our implementation integrates diverse cryptographic hardware and software backends via the uniform interface. Our performance measurements show that the overhead of the uniform API with integrated key management is negligible compared to the individual crypto operation. Our approach enhances the usability, portability, and flexibility of cryptographic support in the IoT.
Additional file 1 of Impact of methods of estimating baseline Serum Creatinine (bSCr) on the incidence and outcomes of acute kidney injury in childhood severe malaria
Creators: name: Ibrahim, Olayinka Rasheed
name: Afolayan, Folake Moriliat
name: Alao, Michael Abel
name: Mohammed, Bashir
name: Suleiman, Bello Mohammed
name: Adedoyin, Olanrewaju Timothy
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
classificationCode: 19999
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplementary Table 1. Details of the mortalityamong children with childhood severe malaria.
Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system
Creators: name: Heinze, Marc-Dominic
name: Chawla, Anshika
name: Cattaneo, Maurizio
name: Kupke, Sascha Young
name: Genzel, Yvonne
name: Reichl, Udo
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 615

description: Respiratory diseases including influenza A virus (IAV) infections represent a major threat to human health. While the development of a vaccine requires a lot of time, a fast countermeasure could be the use of defective interfering particles (DIPs) for antiviral therapy. IAV DIPs are usually characterized by a large internal deletion in one viral RNA segment. Consequentially, DIPs can only propagate in presence of infectious standard viruses (STVs), compensating the missing gene function. Here, they interfere with and suppress the STV replication and might act “universally” against many IAV subtypes. We recently reported a production system for purely clonal DIPs utilizing genetically modified cells. In the present study, we established an automated perfusion process for production of a DIP, called DI244, using an alternating tangential flow filtration (ATF) system for cell retention. Viable cell concentrations and DIP titers more than 10 times higher than for a previously reported batch cultivation were observed. Furthermore, we investigated a novel tubular cell retention device for its potential for continuous virus harvesting into the permeate. Very comparable performances to typically used hollow fiber membranes were found during the cell growth phase. During the virus replication phase, the tubular membrane, in contrast to the hollow fiber membrane, allowed 100% of the produced virus particles to pass through. To our knowledge, this is the first time a continuous virus harvest was shown for a membrane-based perfusion process. Overall, the process established offers interesting possibilities for advanced process integration strategies for next-generation virus particle and virus vector manufacturing.
The harmonic balance method for bifurcation analysis of large-scale nonlinear mechanical systems
Creators: name: Detroux, Thibaut
name: Renson, Ludovic
name: Masset, Luc
name: Kerschen, Gaetan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: The harmonic balance (HB) method is widely used in the literature for analyzing the periodic solutions of nonlinear mechanical systems. The objective of this paper is to exploit the method for bifurcation analysis, i.e., for the detection and tracking of bifurcations of nonlinear systems. To this end, an algorithm that combines the computation of the Floquet exponents with bordering techniques is developed. A new procedure for the tracking of Neimark-Sacker bifurcations that exploits the properties of eigenvalue derivatives is also proposed. The HB method is demonstrated using numerical experiments of a spacecraft structure that possesses a nonlinear vibration isolation device.
description: Journal paper
ФИНАНСОВЫЙ ЭКВИВАЛЕНТ ВОЛОНТЕРСКОЙ ДЕЯТЕЛЬНОСТИ В ОРГАНИЗАЦИИ
Creators: name: ЗЕМЦОВА Ю.Е.
Publisher: name: StudNet
Year: 2020
Subjects: VOLUNTEERING
VOLUNTEER WORK
ECONOMIC ASSESSMENT
ECONOMIC EFFICIENCY
ВОЛОНТЕРСТВО
ВОЛОНТЕРСКИЙ ТРУД
ЭКОНОМИЧЕСКАЯ ОЦЕНКА
ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ

description: В статье рассматривается проблема оценки экономической эффективности волонтерской деятельности, которая играет важную роль для некоммерческих организаций и бизнеса, в виду необходимости оценки показателей устойчивого развития, эффективности реализуемых проектов и программ. Также рассмотрены основные методы проведения экономической оценки волонтерской деятельности, обозначены полюсы и минусы каждого. Обозначен вопрос сложности унифицированной оценки волонтерского труда, а также даны рекомендации по оценке его экономической эффективности.The article deals with the problem of evaluating the economic efficiency of volunteer activities, which play an important role for non-profit organizations and businesses, in view of the need to assess indicators of sustainable development, the effectiveness of projects and programs. The main methods of conducting economic evaluation of volunteer activities are also considered, and the poles and cons of each are indicated. The issue of the complexity of the unified assessment of volunteer work is outlined, as well as recommendations for evaluating its economic efficiency are given.
Cranial shape diversification in horses : variation and covariation patterns under the impact of artificial selection
Creators: name: Hanot, Pauline
name: Bajarsajhan, Žamsranžavyn
name: Guintard, Claude
name: Haruda, Ashleigh Francis
name: Mijiddorj, Enkhbayar
name: Schafberg, Renate
name: Taylor, William
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 576

description: The potential of artificial selection to dramatically impact phenotypic diversity is well known. Large-scale morphological changes in domestic species, emerging over short timescales, offer an accelerated perspective on evolutionary processes. The domestic horse (Equus caballus) provides a striking example of rapid evolution, with major changes in morphology and size likely stemming from artificial selection. However, the microevolutionary mechanisms allowing to generate this variation in a short time interval remain little known. Here, we use 3D geometric morphometrics to quantify skull morphological diversity in the horse, and investigate modularity and integration patterns to understand how morphological associations contribute to cranial evolvability in this taxon. We find that changes in the magnitude of cranial integration contribute to the diversification of the skull morphology in horse breeds. Our results demonstrate that a conserved pattern of modularity does not constrain large-scale morphological variations in horses and that artificial selection has impacted mechanisms underlying phenotypic diversity to facilitate rapid shape changes. More broadly, this study demonstrates that studying microevolutionary processes in domestic species produces important insights into extant phenotypic diversity.
An ensemble meta-estimator to predict source code testability
Creators: name: Zakeri-Nasrabadi, Morteza
name: Parsa, Saeed
Publisher: name: arXiv
Year: 2022
Subjects: subject: Software Engineering (cs.SE)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Unlike most other software quality attributes, testability cannot be evaluated solely based on the characteristics of the source code. The effectiveness of the test suite and the budget assigned to the test highly impact the testability of the code under test. The size of a test suite determines the test effort and cost, while the coverage measure indicates the test effectiveness. Therefore, testability can be measured based on the coverage and number of test cases provided by a test suite, considering the test budget. This paper offers a new equation to estimate testability regarding the size and coverage of a given test suite. The equation has been used to label 23,000 classes belonging to 110 Java projects with their testability measure. The labeled classes were vectorized using 262 metrics. The labeled vectors were fed into a family of supervised machine learning algorithms, regression, to predict testability in terms of the source code metrics. Regression models predicted testability with an R2 of 0.68 and a mean squared error of 0.03, suitable in practice. Fifteen software metrics highly affecting testability prediction were identified using a feature importance analysis technique on the learned model. The proposed models have improved mean absolute error by 38% due to utilizing new criteria, metrics, and data compared with the relevant study on predicting branch coverage as a test criterion. As an application of testability prediction, it is demonstrated that automated refactoring of 42 smelly Java classes targeted at improving the 15 influential software metrics could elevate their testability by an average of 86.87%.
description: 52 pages, 11 figures, 11 tables
The pathophysiology of heart failure in type 2 diabetes
Creators: name: Martin., Jennifer Helen
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Modeling, dynamics and optimal control of Ebola virus spread
Creators: name: Rachah, Amira
name: Torres, Delfim F. M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Optimization and Control (math.OC)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Biological sciences
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 49N90, 92D25, 92D30, 93A30

description: We present a mathematical analysis of the early detection of Ebola virus. The propagation of the virus is analysed by using a Susceptible, Infected, Recovered (SIR) model. In order to provide useful predictions about the potential transmission of the virus, we analyse and simulate the SIR model with vital dynamics, by adding demographic effects and an induced death rate. Then, we compute the equilibria of the model. The numerical simulations confirm the theoretical analysis. Our study describes the 2015 detection of Ebola virus in Guinea, the parameters of the model being identified from the World Health Organization data. Finally, we consider an optimal control problem of the propagation of the Ebola virus, minimizing the number of infected individuals while taking into account the cost of vaccination.
description: This is a preprint of a paper whose final and definite form will be published in the International Journal 'Pure and Applied Functional Analysis', ISSN 2189-3756 (print), ISSN 2189-3764 (online). Submitted 01-Dec-2015; revised 17-Mar-2016; accepted for publication 18-Mar-2016
Clinico-genetic findings in 509 frontotemporal dementia patients
Creators: name: Wagner, Matias
name: Lorenz, Georg
name: Volk, Alexander E.
name: Brunet, Theresa
name: Edbauer, Dieter
name: Berutti, Riccardo
name: Zhao, Chen
name: Anderl-Straub, Sarah
name: Bertram, Lars
name: Danek, Adrian
name: Deschauer, Marcus
name: Dill, Veronika
name: Fassbender, Klaus
name: Fliessbach, Klaus
name: Götze, Katharina S.
name: Jahn, Holger
name: Kornhuber, Johannes
name: Landwehrmeyer, Bernhard
name: Lauer, Martin
name: Obrig, Hellmuth
name: Prudlo, Johannes
name: Schneider, Anja
name: Schroeter, Matthias L.
name: Uttner, Ingo
name: Vukovich, Ruth
name: Wiltfang, Jens
name: Winkler, Andrea S.
name: Zhou, Qihui
name: Ludolph, Albert C.
name: Oexle, Konrad
name: Otto, Markus
name: Diehl-Schmid, Janine
name: Winkelmann, Juliane
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-driven differences in biomarker profiles, disease severity and clinical manifestation by recruiting 509 FTD patients from different centers of the German FTLD consortium where individuals were clinically assessed including biomarker analysis. Exome sequencing as well as C9orf72 repeat analysis were performed in all patients. These genetic analyses resulted in a diagnostic yield of 18.1%. Pathogenic variants in C9orf72 (n = 47), GRN (n = 26), MAPT (n = 11), TBK1 (n = 5), FUS (n = 1), TARDBP (n = 1), and CTSF (n = 1) were identified across all clinical subtypes of FTD. TBK1-associated FTD was frequent accounting for 5.4% of solved cases. Detection of a homozygous missense variant verified CTSF as an FTD gene. ABCA7 was identified as a candidate gene for monogenic FTD. The distribution of APOE alleles did not differ significantly between FTD patients and the average population. Male sex was weakly associated with clinical manifestation of the behavioral variant of FTD. Age of onset was lowest in MAPT patients. Further, high CSF neurofilament light chain levels were found to be related to GRN-associated FTD. Our study provides large-scale retrospective clinico-genetic data such as on disease manifestation and progression of FTD. These data will be relevant for counseling patients and their families.
EasyMLServe: Easy Deployment of REST Machine Learning Services
Creators: name: Neumann, Oliver
name: Schilling, Marcel
name: Reischl, Markus
name: Mikut, Ralf
Publisher: name: KIT Scientific Publishing
Year: 2022

description: Various research domains use machine learning approaches because they can solve complex tasks by learning from data. Deploying machine learning models, however, is not trivial and developers have to implement complete solutions which are often installed locally and include Graphical User Interfaces (GUIs). Distributing software to various users on-site has several problems. Therefore, we propose a concept to deploy software in the cloud. There are several frameworks available based on Representational State Transfer (REST) which can be used to implement cloud-based machine learning services. However, machine learning services for scientific users have special requirements that state-of-the-art REST frameworks do not cover completely. We contribute an EasyMLServe software framework to deploy machine learning services in the cloud using REST interfaces and generic local or web-based GUIs. Furthermore, we apply our framework on two real-world applications, i. e., energy time-series forecasting and cell instance segmentation. The EasyMLServe framework and the use cases are available on GitHub.
Additional file 1 of Heart Rate Variability-Derived Thresholds for Exercise Intensity Prescription in Endurance Sports: A Systematic Review of Interrelations and Agreement with Different Ventilatory and Blood Lactate Thresholds
Creators: name: Kaufmann, Sebastian
name: Gronwald, Thomas
name: Herold, Fabian
name: Hoos, Olaf
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Item description of the modified Standard for Reporting Diagnostic Accuracy Studies Guidelines for Heart Rate Variability Research (STARDHRV) by Dobbs et al. [69] based on Cohen et al. [70].
A ram-pressure threshold for star formation
Creators: name: Whitworth, A. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In turbulent fragmentation, star formation occurs in condensations created by converging flows. The condensations must be sufficiently massive, dense and cool to be gravitationally unstable, so that they start to contract; {\it and} they must then radiate away thermal energy fast enough for self-gravity to remain dominant, so that they continue to contract. For the metallicities and temperatures in local star forming clouds, this second requirement is only met robustly when the gas couples thermally to the dust, because this delivers the capacity to radiate across the full bandwidth of the continuum, rather than just in a few discrete spectral lines. This translates into a threshold for vigorous star formation, which can be written as a minimum ram-pressure Pcrit ~ 4 10^-11 dyne. Pcrit is independent of temperature, and corresponds to flows with molecular hydrogen number-density nH2 and velocity v satisfying nH2 v^2 > 800 cm^-3 (km/s)^2. This in turn corresponds to a minimum molecular hydrogen column-density for vigorous star formation, NH2crit ~ 4 10^21 cm^-2 (SIGMAcrit ~ 100 MSun pc^-2), and a minimum visual extinction AVcrit ~ 9. The characteristic diameter and line-density for a star-forming filament when this threshold is just exceeded -- a sweet spot for local star formation regions -- are 2Rfil ~ 0.1 pc and mufil ~ 13 MSun pc^-2. The characteristic diameter and mass for a prestellar core condensing out of such a filament are 2Rcore ~ 0.1 pc, and Mcore ~ MSun. We also show that fragmentation of a shock-compressed layer is likely to commence while the convergent flows creating the layer are still ongoing, and we stress that, under this circumstance, the phenomenology and characteristic scales for fragmentation of the layer are fundamentally different from those derived traditionally for pre-existing layers.
description: 20 pages, 2 fugures, published in MNRAS
СРАВНИТЕЛЬНЫЙ АНАЛИЗ АНТИВИРУСНЫХ ПРОГРАММ
Creators: name: СИДЕНКО Г. А.
name: РЕДЬКО Г. В.
name: БЕЗНОС О. С.
Publisher: name: StudNet
Year: 2020
Subjects: ВРЕДОНОСНОЕ ПО
АНТИВИРУСНОЕ ПРОГРАММНОЕ ОБЕСПЕЧЕНИЕ
БРАУЗЕР
MALWARE
ANTIVIRUS SOFTWARE
BROWSER

description: В современном мире одним из важным методов защиты информации являются антивирусные программы (АП). Антивирусная программа специализированная программа для обнаружения компьютерных вирусов, а также нежелательных программ и восстановления заражённых такими программами файлов и профилактики предотвращения заражения файлов или операционной системы вредоносным кодом. Эти программы по разному справляются со своими задачами, имеют свои достоинства и недостатки. В статье проведен анализ наиболее используемых АП.In the modern world, one of the most important methods of protecting information is antivirus software (AP). Antivirus program is a specialized program for detecting computer viruses, as well as unwanted programs and recovering files infected by such programs, and prevention preventing infection of files or the operating system with malicious code. These programs in different ways cope with their tasks, have their own advantages and disadvantages. The article analyzes the most used APs.
Analysis of microbial populations in plastic–soil systems after exposure to high poly(butylene succinate-co-adipate) load using high-resolution molecular technique
Creators: name: Tanunchai, Benjawan
name: Juncheed, Kantida
name: Fareed Mohamed Wahdan, Sara
name: Guliyev, Vusal
name: Udovenko, Maria
name: Lehnert, Ann-Sophie
name: Gomes Alves, Eliane
name: Glaser, Bruno
name: Noll, Matthias
name: Buscot, François
name: Blagodatskaya, Evgenia
name: Purahong, Witoon
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 570

description: Background: Bio-based and biodegradable plastics are considered as plastics of the future owing to their ability to decompose under various environmental conditions. However, their effects on the soil microbiome are poorly characterised. In this study, we aimed to investigate the effects of an important bio-based and biodegradable plastic, polybutylene succinate-co-adipate (PBSA), on soil microbial diversity and community composition using high-resolution molecular technique (Illumina sequencing) targeting all three microbial domains: archaea, bacteria, and fungi. Results: Adding high load of PBSA to soil (6% (w/w)) caused a significant decline in archaeal (13%) and fungal (45%) richness and substantial changes in both bacterial (Proteobacteria, Actinobacteria, and Acidobacteria) and fungal (Eurotiomycetes, Sordariomycetes, Leotiomycetes, and Dothideomycetes) community composition compared with no PBSA addition to soil. The combined effects of PBSA and (NH4)2SO4 fertilisation on the soil microbiome were much greater than the effects of PBSA alone. We only detected opportunistic human pathogens in low abundance on PBSA and in the surrounding soil. However, some plant pathogenic fungi were detected and/or enriched on the PBSA films and in surrounding soil. Apart from plant pathogens, many potential microbial control agents and plant growth-promoting microorganisms were also detected/enriched owing to PBSA addition. Adding high load of PBSA together with (NH4)2SO4 fertilisation can either eliminate some plant pathogens or enrich specific pathogens, especially Fusarium solani, which is economically important. Conclusions: We conclude that high load of bio-based and biodegradable PBSA plastic may negatively affect soil microbiome.
When BERT Fails -- The Limits of EHR Classification
Creators: name: Garcia-Agundez, Augusto
name: Eickhoff, Carsten
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Transformers are powerful text representation learners, useful for all kinds of clinical decision support tasks. Although they outperform baselines on readmission prediction, they are not infallible. Here, we look into one such failure case, and report patterns that lead to inferior predictive performance.
Three-dimensional Simulation of Thermal Harmonic Lasing FEL with Detuning of the Fundamental
Creators: name: Salehi, Elham
name: Maraghechi, Behrouz
name: Mirian, Najmeh Sadat
Publisher: name: arXiv
Year: 2016
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Detuning of the fundamental is a way to enhance harmonic generation . By this method, the wiggler is composed of two segments in such a way that the fundamental resonance of the second segment to coincide with the third harmonic of the first segment of the wiggler to generate extreme ultraviolet radiation and x-ray emission. A set of coupled, nonlinear, and first-order differential equations in three dimensions describing the evolution of the electron trajectories and the radiation field with warm beam is solved numerically by CYRUS 3D code in the steady-state for two models (1) seeded free electron laser (FEL) and (2) shot noise on the electron beam (self-amplified spontaneous emission FEL). Thermal effects in the form of longitudinal velocity spread is considered. Three-dimensional simulation describes self-consistently the longitudinal spatial dependence of radiation waists, curvatures, and amplitudes together with the evaluation of the electron beam. The evolutions of the transverse modes are investigated for the fundamental resonance and the third harmonic. Also, the effective modes of the third harmonic are studied. In this paper, we found that detuning of the fundamental with shot noise gives more optimistic result than the seeded FEL.
Additional file 1 of Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
Creators: name: Kosnopfel, Corinna
name: Wendlinger, Simone
name: Niessner, Heike
name: Siewert, Johannes
name: Sinnberg, Tobias
name: Hofmann, Angelika
name: Wohlfarth, Jonas
name: Schrama, David
name: Berthold, Marion
name: Siedel, Claudia
name: Sauer, Birgit
name: Jayanthan, Aarthi
name: Lenz, Georg
name: Dunn, Sandra E.
name: Schilling, Bastian
name: Schittek, Birgit
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
classificationCode: 60506
subject: Virology

description: Additional file 1: Suppl. Figure S1. Specific small molecule inhibitors suppress active RSK signaling in MAPK pathway hyperactivated melanoma cell lines.
Indirect measurement of the $\pmb{(n,γ)^{127}}$Sb cross section
Creators: name: Pogliano, Francesco
name: Larsen, Ann-Cecilie
name: Garrote, Frank Leonel Bello
name: Bjørøen, Marianne Møller
name: Eriksen, Tomas Kvalheim
name: Gjestvang, Dorthea
name: Görgen, Andreas
name: Guttormsen, Magne
name: Li, Kevin Ching Wei
name: Markova, Maria
name: Matthews, Eric Francis
name: Paulsen, Wanja
name: Pedersen, Line Gaard
name: Siem, Sunniva
name: Storebakken, Tellef
name: Tornyi, Tamas Gabor
name: Vevik, Julian Ersland
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Nuclei in the $^{135}$I region have been identified as being a possible bottleneck for the \textit{i} process. Here we present an indirect measurement for the Maxwellian-averaged cross section of $^{126}\text{Sb}(n,γ)$. The nuclear level density and the $γ$-ray strength function of $^{127}$Sb have been extracted from $^{124}$Sn$(α,pγ)^{127}$Sb data using the Oslo method. The level density in the low-excitation-energy region agrees well with known discrete levels, and the higher-excitation-energy region follows an exponential curve compatible with the constant-temperature model. The strength function between $E_γ\approx$ 1.5-8.0 MeV presents several features, such as an upbend and a possibly double-peaked pygmy-like structure. None of the theoretical models included in the nuclear reaction code TALYS seem to reproduce the experimental data. The Maxwellian-averaged cross section for the $^{126}$Sb$(n,γ)^{127}$Sb reaction has been experimentally constrained by using our level-density and strength-function data as input to TALYS. We observe a good agreement with the JINA REACLIB, TENDL, and BRUSLIB libraries, while the ENDF/B-VIII.0 library predicts a significantly higher rate than our results.
The role of endothelin in hypertension and chronic heart failure
Creators: name: Martin., Paul
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia
Creators: name: Sekulovski, Samoil
name: Devant, Pascal
name: Caprioglio Panizza, Silvia
name: Gogakos, Tasos
name: Pitiriciu, Anda
name: Heitmeier, Katharina
name: Ramsay, Ewan Phillip
name: Barth, Marie
name: Schmidt, Carla
name: Tuschl, Thomas
name: Baas, Frank
name: Weitzer, Stefan
name: Martinez, Javier
name: Trowitzsch, Simon
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 572

description: Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur in patients with pontocerebellar hypoplasia (PCH), however, their role in the disease is unclear. Here, we show that intron excision is catalyzed by tetrameric TSEN assembled from inactive heterodimers independently of CLP1. Splice site recognition involves the mature domain and the anticodon-intron base pair of pre-tRNAs. The 2.1-Å resolution X-ray crystal structure of a TSEN15–34 heterodimer and differential scanning fluorimetry analyses show that PCH mutations cause thermal destabilization. While endonuclease activity in recombinant mutant TSEN is unaltered, we observe assembly defects and reduced pre-tRNA cleavage activity resulting in an imbalanced pre-tRNA pool in PCH patient-derived fibroblasts. Our work defines the molecular principles of intron excision in humans and provides evidence that modulation of TSEN stability may contribute to PCH phenotypes.