cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Euprepes aureo-punctatus Grandid.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Squamata
Sauria
Scincidae
Euprepes
Euprepes aureo-Punctatus

description: * Euprepes aureo-punctatus Grandid.
Betsileo v. F M. [1]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 706, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
Structural modulation of p53TAD1-TAZ2 complex upon mutations and post-translational modification
Creators: name: Ghosh, Anamika
name: Ganguly, Debabani
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: The tumour suppressing p53 is a target for genetic alterations in human cancer. Native p53, found in latent state in cells, gets activated following various intracellular or extracellular responses. It plays imperative role in cell-cycle control, via growth-arrest, DNA repair and apoptosis, mainly regulated by post-translational modifications (PTM). However, the influence of PTMs on the activity of p53 is still under extensive experimental and computational study. There are numerous PTM sites in p53, which are reported to regulate its binding affinities with other proteins. Of the many, Thr18 at transactivational domain (TAD) of p53 is reported to amplify p53 activity upon phosphorylation. To understand the molecular basis of p53 recognition by its binding partner upon mutations and PTMs, we have exploited all atom molecular dynamic (MD) simulation of p53TAD1 bound to TAZ2 domain of p300. The MD simulation inferred that phosphorylated and mutated Thr18, as a phospho-mimic, bound with TAZ2, redistributed the charge environment of the interface, thereby modulating the stronger interactions with TAZ2 to enhance the binding efficiency. The electrostatic interactions due to different charge environment together with H-bonding and hydrophobic interaction dictate diverse binding approach between the two. The results of this computational study further explain the importance of the Thr18 as a PTM site in atomistic detail, hence shedding further light to the understanding of how PTMs are imperative for p53 activity to protect the cellular world. Communicated by Ramaswamy H. Sarma
Cross-Calibration of Cluster Mass-Observables
Creators: name: Cunha, Carlos
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: This paper is a first step towards developing a formalism to optimally extract dark energy information from number counts using multiple cluster observation techniques. We use a Fisher matrix analysis to study the improvements in the joint dark energy and cluster mass-observables constraints resulting from combining cluster counts and clustering abundances measured with different techniques. We use our formalism to forecast the constraints in Omega_{DE} and w from combining optical and SZ cluster counting on a 4000 sq. degree patch of sky. We find that this cross-calibration approach yields ~2 times better constraints on Omega_{DE} and w compared to simply adding the Fisher matrices of the individually self-calibrated counts. The cross-calibrated constraints are less sensitive to variations in the mass threshold or maximum redshift range. A by-product of our technique is that the correlation between different mass-observables is well constrained without the need of additional priors on its value.
description: 14 pages, 10 figures, submitted to PRD on 08/08/08. This version incorporates referees' suggestions
Topological Electronic Structure and Transport Properties of the Distorted Rutile-type WO$_2$
Creators: name: Muramatsu, Yuto
name: Hirai, Daigorou
name: Kawamura, Mitsuaki
name: Minami, Susumu
name: Ikeda, Yoshitaka
name: Shimada, Takahiro
name: Kojima, Keita
name: Katayama, Naoyuki
name: Takenaka, Koshi
Publisher: name: arXiv
Year: 2025
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We elucidate the transport properties and electronic structures of distorted rutile-type WO2. Electrical resistivity and Hall effect measurements of high-quality single crystals revealed the transport property characteristics of topological materials; these characteristics included an extremely large magnetoresistance of 13,200% (2 K and 9 T) and a very high carrier mobility of 25,700 cm2 V-1 s-1 (5 K). First-principles calculations revealed Dirac nodal lines (DNL) near the Fermi energy in the electronic structure when spin-orbit interactions (SOIs) were absent. Although these DNLs mostly disappeared in the presence of SOIs, band crossings at high-symmetry points in the reciprocal space existed as Dirac points. Furthermore, DNLs protected by nonsymmorphic symmetry persisted on the ky = π/b plane. The unique transport properties originating from the topological electronic structure of chemically and thermally stable WO2 could represent an opportunity to investigate the potential electronic applications of the material.
description: 9 pages, 6 figures, 1 table
A Fast New Public Code for Computing Photon Orbits in a Kerr Spacetime
Creators: name: Dexter, Jason
name: Agol, Eric
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Relativistic radiative transfer problems require the calculation of photon trajectories in curved spacetime. We present a novel technique for rapid and accurate calculation of null geodesics in the Kerr metric. The equations of motion from the Hamilton-Jacobi equation are reduced directly to Carlson's elliptic integrals, simplifying algebraic manipulations and allowing all coordinates to be computed semi-analytically for the first time. We discuss the method, its implementation in a freely available FORTRAN code, and its application to toy problems from the literature.
description: 15 pages, 10 figures, accepted by ApJ
CasCalib : cascaded calibration for motion capture from sparse unsynchronized cameras
Creators: name: Tang, James
Publisher: name: University of British Columbia
Year: 2023

description: It is now possible to estimate 3D human pose from monocular images with off-the-shelf 3D pose estimators. However, many practical applications require fine-grained absolute pose information for which multi-view cues and camera calibration are necessary. Such multi-view recordings are laborious because they require manual calibration, and are expensive when using dedicated hardware. Our goal is full automation, which includes temporal synchronization, as well as intrinsic and extrinsic camera calibration. This is done by using persons in the scene as the calibration objects. We attain this generality by partitioning the high-dimensional time and calibration space into a cascade of subspaces, and introduce tailored algorithms to optimize each efficiently and robustly. The outcome is an easy-to-use, flexible, and robust motion capture toolbox that we release to enable scientific applications, which we demonstrate on diverse multi-view benchmarks.
Supplementary Information (SI) of the Manuscript “On Some Fundamental Challenges in Monitoring Epidemics” from On some fundamental challenges in monitoring epidemics
Creators: name: Vasiliauskaite, Vaiva
name: Antulov-Fantulin, Nino
name: Helbing, Dirk
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: 80110 Simulation and Modelling
subject: FOS: Computer and information sciences
subject: 80201 Analysis of Algorithms and Complexity

description: Epidemic models often reflect characteristic features of infectious spreading processes by coupled nonlinear differential equations considering different states of health (such as susceptible, infectious or recovered). This compartmental modelling approach, however, delivers an incomplete picture of the dynamics of epidemics, as it neglects stochastic and network effects, and the role of the measurement process, on which the estimation of epidemiological parameters and incidence values relies. In order to study the related issues, we combine established epidemiological spreading models with a measurement model of the testing process, considering the problems of false positives and false negatives as well as biased sampling. Studying a model-generated ground truth in conjunction with simulated observation processes (virtual measurements) allows one to gain insights into the fundamental limitations of purely data-driven methods when assessing the epidemic situation. We conclude that epidemic monitoring, simulation, and forecasting are wicked problems, as applying a conventional data-driven approach to a complex system with nonlinear dynamics, network effects, and uncertainty can be misleading. Nevertheless, some of the errors can be corrected for, using scientific knowledge of the spreading dynamics and the measurement process. We conclude that such corrections should generally be part of epidemic monitoring, modelling and forecasting efforts.This article is part of the theme issue ‘Data science approaches to infectious diseases surveillance’.
Tunneling across dilaton-axion black holes
Creators: name: Ghosh, Tanwi
name: SenGupta, Soumitra
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work we study both charged and uncharged particles tunneling across the horizon of spherically symmetric dilaton-axion black holes using Parikh-Wilczek tunneling formalism. Such black hole solutions have much significance in string theory based models. For different choices of the dilaton and axion couplings with the electromagnetic field, we show that the tunneling probability depends on the difference between initial and final entropies of the black hole. Our results, which agrees with similar results obtained for other classes of black holes, further confirm the usefulness of Parikh-Wilczek formalism to understand Hawking radiation. The emission spectrum is shown to agree with a purely thermal spectrum only in the leading order. The modification of the proportionality factor in the area-entropy relation in the Bekenstien-Hawking formula has been determined.
description: 13 pages, To appear in Phys.Lett.B
Novel tetrakis–phthalocyanines bearing pyrimidine derivative: crystal XRD analysis, enzyme inhibition, molecular docking, and anticancer effects
Creators: name: Günsel, Armağan
name: Yazar, Bilge
name: Taslimi, Parham
name: Erden, Yavuz
name: Taskin-Tok, Tugba
name: Pişkin, Hasan
name: Bilgiçli, Ahmet T.
name: Yarasir, M. Nilüfer
name: Gülçin, İlhami
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: In this study, the novel 4-(4-Aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material was synthesized and its 3D structure was verified by the single crystal X-ray diffraction experiment. Then, its peripherally tetra-substituted phthalocyanines (2,3) and the methylated derivatives (2a,3a) containing pyrimidine derivative were synthesized. All these newly synthesized compounds were characterized with various spectroscopic methods such as UV–Vis, FT-IR, 1H-NMR, 13C-NMR and MALDI-TOF MS by obtaining satisfactory results. In addition, these novel phthalocyanines effectively inhibited acetylcholinesterase enzyme, with Ki values in the range of 10.43 ± 2.38 to 41.70 ± 9.32 µM. For the related enzyme, the IC50 values were obtained in the range of 11.68 to 44.28 µM. For α-glycosidase enzyme the most effective Ki values of (3a) and (2) were with Ki values of 92.87 ± 10.70 and 95.18 ± 17.83 µM, respectively. Indeed, the most potent phthalocyanines against both enzymes were recorded for the purpose of investigating interaction modes of these complexes in the active site of the target enzyme. The cytotoxicity potential of these phthalocyanines against human breast, colon, and prostate cancers demonstrated that these compounds had normal cytotoxic effects. Communicated by Ramaswamy H. Sarma
IAM_COMPACT_D5.4_Modelling_out_of_ordinary_extremes
Creators: name: Khourdajie, Alaa Al
name: Fragkos, Panagiotis
name: Zisarou, Eleftheria
name: van de Ven, Dirk-Jan
name: Rinaldi, Lorenzo
name: Hawkes, Adam
name: Mittal, Shivika
name: Nieto Vega, Jaime
Publisher: name: Zenodo
Year: 2024

description: The deliverable aims to enhance the scenario analyses in WP4 by exploring a broad spectrum of uncertainties, including extreme environmental, technological, policy, and societal shifts. It focuses on resilient pathways and technologies in both national and global contexts, under extreme conditions. The urgency of addressing climate change underscores the importance of integrated assessment models (IAMs) in decision-making, especially in energy. IAMs, however, struggle with the complexities of real-world systems and extreme events like sudden technological or policy changes and natural disasters. The study addresses these challenges by examining critical questions across dimensions, defining extremes, understanding geographical differences, identifying system vulnerabilities, assessing model adaptability, and integrating new frameworks and technologies, aiming to improve IAMs’ response to extreme events in the energy sector.  

The literature review discusses IAMs’ role in capturing extreme events, their types, impacts, and the need for IAMs to incorporate such conditions beyond conventional models. It categorises extremes, explores their origins and impacts, and proposes a scenario framework and narratives informed by recent studies and the NGFS scenario approach. This framework considers climate and socio-economic tipping points through transformational response and resilience, presenting four narratives: Business as Usual, Unadaptive Transformation, Effective Transformation, and Incremental Resilience.  

Expert interviews explore how technologies and measures can enhance resilience in transformation pathways during extreme events and identify feasible mitigation trajectories. Key themes from the interviews highlight the distinction between risk and uncertainty, technological impacts, abrupt policy changes, regional differences, vulnerabilities, and challenges in adapting IAMs. The interviews underscore the need for adaptable strategies, robust modelling, and interdisciplinary collaboration.
Electron transport in a two-terminal Aharonov-Bohm ring with impurities
Creators: name: Kokoreva, M. A.
name: Margulis, V. A.
name: Pyataev, M. A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Electron transport in a two-terminal Aharonov-Bohm ring with a few short-range scatterers is investigated. An analytical expression for the conductance as a function of the electron Fermi energy and magnetic flux is obtained using the zero-range potential theory. The dependence of the conductance on positions of scatterers is studied. We have found that the conductance exhibits asymmetric Fano resonances at certain energies. The dependence of the Fano resonances on magnetic field and positions of impurities is investigated. It is found that collapse of the Fano resonances occurs and discrete energy levels in the continuous spectrum appear at certain conditions. An explicit form for the wave function corresponding to the discrete level is obtained.
description: 25 pages (one-column), 8 figures
Location-Dependent Communications using Quantum Entanglement
Creators: name: Malaney, Robert A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The ability to unconditionally verify the location of a communication receiver would lead to a wide range of new security paradigms. However, it is known that unconditional location verification in classical communication systems is impossible. In this work we show how unconditional location verification can be achieved with the use of quantum communication channels. Our verification remains unconditional irrespective of the number of receivers, computational capacity, or any other physical resource held by an adversary. Quantum location verification represents a new application of quantum entanglement that delivers a feat not possible in the classical-only channel. For the first time, we possess the ability to deliver real-time communications viable only at specified geographical coordinates.
description: 11 pages, 1 figure
Local control of ultrafast dynamics in magnetic nanoparticles
Creators: name: Sukhov, A.
name: Berakdar, J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Using the local control theory we derive analytical expressions for magnetic field pulses that steer the magnetization of a monodomain magnetic nanoparticle to a predefined state. Finite-temperature full numerical simulations confirm the analytical results and show that a magnetization switching or freezing is achievable within few precessional periods and that the scheme is exploitable for fast thermal switching.
การสร้างสรรค์หุ่นกระบอกไทยในยุคไฮเทคโนโลยีเพื่อสื่อสารในสื่อดิจิทัล
Creators: name: นิเวศ แววสมณะ
Publisher: name: สำนักงานบริหารการวิจัย นวัตกรรมและการสร้างสรรค์
Year: 2564
Subjects: การออกแบบ
การสร้างสรรค์
การพัฒนา
ไฮเทคโนโลยี
สื่อดิจิทัล
หุ่นกระบอกไทย

description: วารสารมหาวิทยาลัยศิลปากร, 41, 4, 1-14
Computational Complexity and Numerical Stability of Linear Problems
Creators: name: Holtz, Olga
name: Shomron, Noam
Publisher: name: arXiv
Year: 2009
Subjects: subject: Computational Complexity (cs.CC)
subject: Data Structures and Algorithms (cs.DS)
subject: Numerical Analysis (math.NA)
subject: History and Overview (math.HO)
subject: Rings and Algebras (math.RA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We survey classical and recent developments in numerical linear algebra, focusing on two issues: computational complexity, or arithmetic costs, and numerical stability, or performance under roundoff error. We present a brief account of the algebraic complexity theory as well as the general error analysis for matrix multiplication and related problems. We emphasize the central role played by the matrix multiplication problem and discuss historical and modern approaches to its solution.
description: 16 pages; updated to reflect referees' remarks; to appear in Proceedings of the 5th European Congress of Mathematics
Interacting Binaries with Eccentric Orbits II. Secular Orbital Evolution Due To Non-Conservative Mass Transfer
Creators: name: Sepinsky, J. F.
name: Willems, B.
name: Kalogera, V.
name: Rasio, F. A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate the secular evolution of the orbital semi-major axis and eccentricity due to mass transfer in eccentric binaries, allowing for both mass and angular momentum loss from the system. Adopting a delta function mass transfer rate at the periastron of the binary orbit, we find that, depending on the initial binary properties at the onset of mass transfer, the orbital semi-major axis and eccentricity can either increase or decrease at a rate linearly proportional to the magnitude of the mass transfer rate at periastron. The range of initial binary mass ratios and eccentricities that leads to increasing orbital semi-major axes and eccentricities broadens with increasing degrees of mass loss from the system and narrows with increasing orbital angular momentum loss from the binary. Comparison with tidal evolution timescales shows that the usual assumption of rapid circularization at the onset of mass transfer in eccentric binaries is not justified, irrespective of the degree of systemic mass and angular momentum loss. This work extends our previous results for conservative mass transfer in eccentric binaries and can be incorporated into binary evolution and population synthesis codes to model non-conservative mass transfer in eccentric binaries.
description: 6 pages, 3 figures, Accepted for publication in ApJ. To appear September 2009
Quotient Complexity of Closed Languages
Creators: name: Brzozowski, J.
name: Jirásková, G.
name: Zou, C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences

description: A language L is prefix-closed if, whenever a word w is in L, then every prefix of w is also in L. We define suffix-, factor-, and subword-closed languages in the same way, where by subword we mean subsequence. We study the quotient complexity (usually called state complexity) of operations on prefix-, suffix-, factor-, and subword-closed languages. We find tight upper bounds on the complexity of the prefix-, suffix-, factor-, and subword-closure of arbitrary languages, and on the complexity of boolean operations, concatenation, star and reversal in each of the four classes of closed languages. We show that repeated application of positive closure and complement to a closed language results in at most four distinct languages, while Kleene closure and complement gives at most eight languages.
description: 12 pages, 5 eps figures, uses llncs
ТАРБИЯ — ТАРБИЯЧИ ВА ТАРБИЯЛАНУВЧИ ФАОЛИЯТЛАРИНИ ЎЗ ИЧИГА ОЛГАН ИККИ ЀҚЛАМА ЖАРАЀНДИР
Creators: name: Кукон Давлат педагогика институти Бошлангич таълим факультети  Факультетлараро педагогика ва психология кафедра  ўқитувчиси  Абдуллаева Дилором Номановна Мамаюсупова Дилдора  Таълим менежменти 2-босқичт талабаси. Олимжонова Зайнабхон  Таълим менежменти 2-босқич талабаси.
Publisher: name: Zenodo
Year: 2023

description: Ушбу мақолада тарбиячилар — билим ва тарбияга эга бўлган кишилар, тарбияланувчилар — билим ва тажриба ўрганувчи ѐшлардир.Тарбия воситалари бирон-бир тарбиявий масалани мақсадга мувофиқтарбия жараѐнида ўқитувчи якка ўқувчи ѐки синф жамоаси манфаати йўлида бирон-бир тарбиявий масалани ҳал қилиш учун ўқувчиларнинг ѐш ва индивидуал хусусиятларини, тарбияланганлик даражаларини, педагогик вазият характерини ҳисобга олган ҳолда таъсир этиш шакллари мажмуасини ёритиб берилган.
Калит сўзлар: тарбиячи,билим тарбияланувчи , тажриба , ўрганувчи , ѐшлар,  восита ,жараѐн, ўқитувчи, ўқувчи , синф , жамоа, индивидуал.
Near-field radiative heat transfer between a sphere and a substrate
Creators: name: Narayanaswamy, Arvind
name: Shen, Sheng
name: Chen, Gang
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Near-field force and energy exchange between two objects due to quantum electrodynamic fluctuations give rise to interesting phenomena such as Casimir and van der Waals forces, and thermal radiative transfer exceeding Planck's theory of blackbody radiation. Although significant progress has been made in the past on the precise measurement of Casimir force related to zero-point energy, experimental demonstration of near-field enhancement of radiative heat transfer is difficult. In this work, we present a sensitive technique of measuring near-field radiative transfer between a microsphere and a substrate using a bi-material atomic force microscope (AFM) cantilever, resulting in "heat transfer-distance" curves. Measurements of radiative transfer between a sphere and a flat substrate show the presence of strong near-field effects resulting in enhancement of heat transfer over the predictions of the Planck blackbody radiation theory.
description: 12 pages, 2 figures
Evidence for Graphene Edges Beyond Zigzag and Armchair
Creators: name: Koskinen, Pekka
name: Malola, Sami
name: Häkkinen, Hannu
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The edges of nanoscopic objects determine most of their properties. For this reason the edges of honeycomb carbon--always considered either zigzag- or armchair-like--need special attention. In this report we provide experimental evidence confirming a previous unexpected prediction: zigzag is a metastable edge, as its planar reconstruction lowers energy and forms the most stable graphene edge. Our evidence is based on re-analyzing a recent experiment. Since the reconstructed edge, along with other unconventional edges we discuss, has distinct chemical properties, this discovery urges for care in experiments and theory--we must enter the realm beyond zigzag and armchair.
description: 3 pages, 2 figures
Phosphorus–nitrogen compounds. Part 58. Syntheses, structural characterizations and biological activities of 4-fluorobenzyl-spiro(N/O)cyclotriphosphazene derivatives
Creators: name: Binici, Arzu
name: Elmas, Gamze
name: Okumuş, Aytuğ
name: Tayhan, Seçil Erden
name: Hökelek, Tuncer
name: Şeker, Büşra Nur
name: Açık, Leyla
name: Kılıç, Zeynel
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: The starting compound, tetrachloro-4-fluorobenzyl-spiro(N/O)cyclotriphosphazene (2), was synthesized from the substitution reaction of hexachlorocyclotriphosphazatriene (N3P3Cl6; trimer; HCCP) with sodium 3-(4-fluorobenzylamino)-1-propanoxide (1). Reactions of spiro (2) with excess 1-(2-aminoethyl)-piperidine, 4-(2-aminoethyl)-morpholine, 1-(2-hydroxyethyl)piperidine and 4-(2-aminoethyl)morpholine yielded the fully substituted cyclotriphosphazene derivatives (2a–2d), respectively. Elemental analysis, mass spectrometry (ESI-MS), FTIR, 1H-, 13C- and 31P-NMR data confirmed the structure of the new cyclotriphosphazenes (2a–2d); and the crystal structure of 2 was also identified by X-ray crystallography. The quantum mechanical DFT calculations of 2 were performed to estimate the geometry optimization, total energy, orientation of frontier molecular orbitals (HOMOs and LUMOs), and chemical parameters. In addition, antibacterial and antifungal activities of the fully substituted 4-fluorobenzyl-spiro(N/O)cyclotriphosphazenes (2a–2d) were investigated against G(+) and G(−) bacteria and fungi. Using agarose gel electrophoresis, the DNA cleavage activities of these phosphazenes on double-stranded plasmid DNA were evaluated. To evaluate the abilities of compounds 2a–2d to inhibit cell proliferation in different concentrations, the antiproliferative and antimigrative activities against prostate adenocarcinoma (PC3), breast cancer (MCF7) and colon cancer (HT29) cell lines were studied in vitro; and the compound 2c was determined to be the most efficient against the three cancer cells. Communicated by Ramaswamy H. Sarma
In Search for Extraterrestrial High Energy Neutrinos
Creators: name: Anchordoqui, Luis A.
name: Montaruli, Teresa
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this paper we review the search for astrophysical neutrinos. We begin by summarizing the various theoretical predictions which correlate the expected neutrino flux with data from other messengers, specifically gammas and ultra-high energy cosmic rays. We then review the status and results of neutrino telescopes in operation and decommissioned, the methods used for data analysis and background discrimination. Particular attention is devoted to the challenge enforced by the highly uncertain atmospheric muon and neutrino backgrounds in relation to searches of diffuse neutrino fluxes. Next, we examine the impact of existing limits on neutrino fluxes on studies of the chemical composition of cosmic rays. After that, we show that not only do neutrinos have the potential to discover astrophysical sources, but the huge statistics of atmospheric muons can be a powerful tool as well. We end by discussing the prospects for indirect detection of dark matter with neutrino telescopes.
description: Solicited Review Article submitted to Annual Review of Nuclear and Particle Science; 50 pages and 15 figures; the review is limited to 150 references, so many of them have been grouped. See http://www.icecube.wisc.edu/~tmontaruli/review for errata and other features
New observables to test the Color Glass Condensate beyond the large-N_c limit
Creators: name: Marquet, Cyrille
name: Weigert, Heribert
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The JIMWLK framework offers a powerful tool to calculate the energy dependence of QCD observables at high energies. Despite a growing number of observables considered for phenomenological analysis, few features of JIMWLK evolution beyond its evolution speed are yet well constrained by experiment. We argue that meson production cross-sections have the potential to provide qualitatively new insights and allow to address issues both beyond the large-N_c limit and at higher twist. These cross-sections generically contain four point functions whose evolution is shown to follow from the JIMWLK framework. The Gaussian truncation is used to provide an efficient and practical means of calculating the evolution of four point correlators beyond the large-N_c limit.
description: 33 pages
BayesCLUMPY: Bayesian Inference with Clumpy Dusty Torus Models
Creators: name: Ramos, A. Asensio
name: Almeida, C. Ramos
Publisher: name: arXiv
Year: 2009
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Our aim is to present a fast and general Bayesian inference framework based on the synergy between machine learning techniques and standard sampling methods and apply it to infer the physical properties of clumpy dusty torus using infrared photometric high spatial resolution observations of active galactic nuclei. We make use of the Metropolis-Hastings Markov Chain Monte Carlo algorithm for sampling the posterior distribution function. Such distribution results from combining all a-priori knowledge about the parameters of the model and the information introduced by the observations. The main difficulty resides in the fact that the model used to explain the observations is computationally demanding and the sampling is very time consuming. For this reason, we apply a set of artificial neural networks that are used to approximate and interpolate a database of models. As a consequence, models not present in the original database can be computed ensuring continuity. We focus on the application of this solution scheme to the recently developed public database of clumpy dusty torus models. The machine learning scheme used in this paper allows us to generate any model from the database using only a factor 10^-4 of the original size of the database and a factor 10^-3 in computing time. The posterior distribution obtained for each model parameter allows us to investigate how the observations constrain the parameters and which ones remain partially or completely undetermined, providing statistically relevant confidence intervals. As an example, the application to the nuclear region of Centaurus A shows that the optical depth of the clouds, the total number of clouds and the radial extent of the cloud distribution zone are well constrained using only 6 filters.
description: 12 pages, 7 figures, accepted for publication in ApJ
Hybrid nucleobases as new and efficient unnatural genetic letters
Creators: name: Jena, N. R.
name: Das, P.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: To expand the existing genetic letters beyond the natural four nucleotides, such as G, C, A, and T, it is necessary to design robust nucleotides that can not only produce stable and unperturbed DNA but also function naturally in living cells. Although hydrophobic bases, such as d5SICS (2,6-dimethyl-2H-isoquiniline-1-thione) and dNaM (2-methoxy-3-methylnaphthalene) were shown to be replicated in bacterial cells, the d5SICS:dNaM base–pair was found to perturb the structure of the duplex DNA. Therefore, it is necessary to design nucleobases that can form base pairs like the natural G:C and A:T pairs. Here, a reliable dispersion-corrected density functional theory has been used to design several nucleobases that can produce three-hydrogen-bonded base pairs like the G:C pair. In doing so, the Watson–Crick faces of d5SICS and dNaM were modified by replacing the hydrophobic groups with hydrogen bond donors and acceptors. As dNaM contains an unnatural C-glycosidic bond (C-dNaM), it was also modified to contain the natural N-glycosidic bond (N-dNaM). This technique produced 91 new bases (N-d5SICS-X (X = 1–33), C-dNaM-X (X = 1–35), and N-dNaM-X (X = 1–23), where X is the different types of modifications applied to d5SICS and dNaM) and 259 base–pairs. Among these base pairs, 76 base pairs are found to be more stable than the G:C pair. Interestingly, the N-d5SICS-32:C-dNaM-32 and N-d5SICS-32:N-dNaM-20 pairs are found to be the most stable with binding energies of about −28.0 kcal/mol. The base-pair patterns of these pairs are also analogous to that of the G:C pair. Hence, it is proposed that N-d5SICS-32, C-dNaM-32, and N-dNaM-20 would act as efficient new genetic letters to produce stable and unperturbed artificial DNA. Communicated by Ramaswamy H. Sarma
Characterising flow through artificial poro-elastic media
Creators: name: Basak, Raunak
Publisher: name: University of British Columbia
Year: 2023

description: Porous deformable materials are ubiquitous in nature. Fluid flow through any deformable porous medium cause deformation of the medium and in turn, this deformation affects the fluid flow and such materials are poro-elastic. Flow through deformable porous media is relevant to applications such as soil consolidation, CO₂ sequestration, infiltration and transport processes in human tissue including for drug delivery. This work aims to investigate certain aspects of such flow using a purposely designed artificial deformable porous medium (matrix). The matrix is made with polydimethylsiloxane using the solvent casting and particulate leaching technique. This method helps control parameters like pore size, porosity, and stiffness of the matrix. The permeability of several samples is measured as a function of strain. The flow experimental setup comprises a tightly sealed chamber and a mechanism to strain the porous matrix and the pressure difference and the resultant flow rate through the matrix are measured. This gives us the hydraulic resistance which when combined with Darcy’s Law helps to calculate the associated permeability. As the externally applied compressive strain on the matrix increases, the permeability of the matrix decreases. We derive strain-permeability and porosity-permeability relationships from the measurements for comparison with existing models, and we observe that the matrix permeability varies exponentially with strain and porosity. A similar setup also permits the observation of flow-induced deformation of the matrix as a function of driving pressure and fluid viscosity. As the fluid flow takes place through the matrix, a camera captures seed particles present on the outside of the deforming porous matrix during the flow process and the fluid induced deformation and strain profile is visualized using Digital Image Correlation. We observe a non-uniform deformation/strain profile. The flow resistance of the deformed matrix is calculated using the previously derived strain-permeability relationship and it differs only slightly from the measured resistance value.
Thinning, Entropy and the Law of Thin Numbers
Creators: name: Harremoes, Peter
name: Johnson, Oliver
name: Kontoyiannis, Ioannis
Publisher: name: arXiv
Year: 2009
Subjects: subject: Information Theory (cs.IT)
subject: Probability (math.PR)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Renyi's "thinning" operation on a discrete random variable is a natural discrete analog of the scaling operation for continuous random variables. The properties of thinning are investigated in an information-theoretic context, especially in connection with information-theoretic inequalities related to Poisson approximation results. The classical Binomial-to-Poisson convergence (sometimes referred to as the "law of small numbers" is seen to be a special case of a thinning limit theorem for convolutions of discrete distributions. A rate of convergence is provided for this limit, and nonasymptotic bounds are also established. This development parallels, in part, the development of Gaussian inequalities leading to the information-theoretic version of the central limit theorem. In particular, a "thinning Markov chain" is introduced, and it is shown to play a role analogous to that of the Ornstein-Uhlenbeck process in connection to the entropy power inequality.
Implications of primordial black holes on the first stars and the origin of the super--massive black holes
Creators: name: Bambi, Cosimo
name: Spolyar, Douglas
name: Dolgov, Alexander D.
name: Freese, Katherine
name: Volonteri, Marta
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: If the cosmological dark matter has a component made of small primordial black holes, they may have a significant impact on the physics of the first stars and on the subsequent formation of massive black holes. Primordial black holes would be adiabatically contracted into these stars and then would sink to the stellar center by dynamical friction, creating a larger black hole which may quickly swallow the whole star. If these primordial black holes are heavier than $\sim 10^{22} {\rm g}$, the first stars would likely live only for a very short time and would not contribute much to the reionization of the universe. They would instead become $10 - 10^3 M_\odot$ black holes which (depending on subsequent accretion) could serve as seeds for the super--massive black holes seen at high redshifts as well as those inside galaxies today.
description: 16 pages, 2 figures. v2: refereed version
A New Distribution Function for Relativistic Counterstreaming Plasmas
Creators: name: Tautz, R. C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The particle distribution function that describes two interpenetrating plasma streams is re-investigated. It is shown how, based on the Maxwell-Boltzmann-Jüttner distribution function that has been derived almost a century ago, a counterstreaming distribution function can be derived that uses velocity space. Such is necessary for various analytical calculations and numerical simulations that are reliant on velocity coordinates rather than momentum space. The application to the electrostatic two-stream instability illustrates the differences caused by the use of the relativistic distribution function.
description: Accepted for publication in Astrophysics & Space Science
title: Developing methods to detect and remedy DNA damage in sperm
Creators: name: Aquilina, Marie Claire
Publisher: name: University of Kent
Year: 2023

description: Infertility affects millions of couples worldwide, with male-related factors playing a significant role. While basic semen analysis is a standard method for evaluating male infertility, advanced sperm testing can enhance its accuracy. To gain insights into urologists' perspectives on advanced semen analysis tests, a survey was conducted among urologists from different geographical regions. The survey revealed a consensus on clinically relevant parameters in basic semen analysis. Among the various advanced sperm tests offered by urologists, sperm DNA damage testing was the most common. Challenges such as lack of familiarity, test availability, and cost were cited as reasons for not offering advanced testing. Analyzing the underlying causes of increased sperm DNA damage is crucial for guiding patient treatment. Oxidative stress is recognized as a significant contributor to sperm DNA damage, and assessing oxidative stress levels provides valuable information. Seminal oxidative stress can be assessed by determining oxidation-reduction potential (ORP) or reactive oxygen species (ROS) levels. High ORP and/or ROS levels were associated with poorer sperm parameters, and higher levels of sperm DNA damage. To address the need for cost-effective and readily available tests, an in-house flow cytometric sperm DNA damage testing service was validated. Data obtained from the validation of the acridine orange-based flow cytometric test (AOFT) demonstrated its reliability and consistency. Lifestyle modifications and innovative sperm preparation techniques, such as microfluidic-based sperm preparation, can help mitigate sperm DNA damage. Microfluidic devices enable the natural selection of sperm based on various parameters, and an investigative study has shown the microfluidic sperm separation device to produce comparable results to the gold standard method, density gradient centrifugation.
Euprepes albilabris Hall.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Squamata
Sauria
Scincidae
Euprepes

description: * Euprepes albilabris Hall.
Kamerun v. H. Dr. Passavant. [1]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 706, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
Computational design of new tacrine analogs: an in silico prediction of their cholinesterase inhibitory, antioxidant, and hepatotoxic activities
Creators: name: Djafarou, Selsabil
name: Khodja, Imene Amine
name: Boulebd, Houssem
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Tacrine, the first drug approved for the treatment of Alzheimer's disease (AD), is a non-competitive cholinesterase inhibitor withdrawn due to its acute hepatotoxicity. However, new non-hepatotoxic forms of tacrine have been actively researched. Moreover, several recent reports have shown that oxidative stress is the cause of damage and plays a role in the pathogenesis of several neurodegenerative diseases including AD. The aim of the present study is the design of new easily synthesized tacrine analogs with less hepatotoxicity and potent antioxidant activity. In this context, a library of 34 novel tacrine analogs bearing an antioxidant fragment was designed and evaluated for its hepatotoxicity as well as anticholinesterase and antioxidant activities using computational methods. As a result, six new tacrine analogs have been proposed as potential inhibitors of cholinesterase with antioxidant activity and low or no hepatotoxicity. Furthermore, ADME calculations suggest that these compounds are promising oral drug candidates. Communicated by Ramaswamy H. Sarma
Further details of models and parameters from Calibrating COVID-19 susceptible-exposed-infected-removed models with time-varying effective contact rates
Creators: name: Gleeson, James P.
name: Brendan Murphy, Thomas
name: O’Brien, Joseph D.
name: Friel, Nial
name: Bargary, Norma
name: O’Sullivan, David J. P.
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Further details of models and parameters
A Class of Stationary Sequences
Creators: name: Smarandache, Florentin
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Mathematics (math.GM)
subject: FOS: Mathematics
subject: 11K31

description: We define a class of sequences ${a_n}$ by $a_1=a$ and $a_{n+1}=P(a_n)$, where $P(x)$ is a polynomial with real coefficients. We then find out for which values $a$ and for which polynomials $P(x)$ these sequences will be constant after a certain rank. Then we generalize it from polynomials $P(x)$ to real functions $f(x)$.
description: 2 pages
STAT5 inhibitor Pimozide as a probable therapeutic option in overcoming Ponatinib resistance in K562 leukemic cells
Creators: name: Gumus, Nurcan
name: Gunduz, Cumhur
name: Kaymaz, Burcin Tezcanli
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Signal Transducer and Activator of Transcription 5 (STAT5) is a transcription factor that plays a key role in neoplasia, triggered by the fusion oncogene BCR-ABL1; it is not only an essential protein for the pathogenesis of chronic myeloid leukemia (CML), but also its overexpression is associated with drug resistance developed toward various generations of Tyrosine Kinase Inhibitors (TKIs); these are still accepted as gold standard therapeutics for the treatment of CML. In this study, it was investigated whether suppression of STAT5 via a “STAT5 inhibitor” Pimozide resulted in any regain of chemosensitivity to third-generation TKI Ponatinib. Accordingly, the experimental work was designed on both parental CML cell line K562WT and its 1 nM Ponatinib-resistant counterpart, indicated as K562-Pon1. Based on the experimental results, Pimozide was more effective in resistant cells compared to wild-type cells for inducing apoptosis and block cell arrest. Combination therapy of Pimozide and Ponatinib demonstrated that STAT5 was a significant protein for regaining chemosensitivity to Ponatinib when its expression was suppressed both at mRNA and protein level. In conclusion, we consider that STAT5 inhibitor Pimozide can be a good alternative or combination therapy with TKIs for patients suffering from chemotherapeutic drug resistance. Communicated by Ramaswamy H. Sarma