cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Pictorial review of Pancreatic cystic lesions: Radiological work-up
Creators: name: Kolleri, Jouhar Jabeen
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Pancreas
subject: CT
subject: MR
subject: Imaging sequences
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: • To identify key imaging features that distinguish the different types of cystic pancreatic lesions. • To describe the best diagnostic modality for identifying different cystic pancreatic lesions. • To show imaging findings that enable the...
title: A repeat audit to measure unnecessary scan field length in Computerised Tomography Kidneys, Ureters, and Bladder (CT KUB) scans for renal colic.
Creators: name: Stride, Rebecca
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radiographers
subject: Radioprotection / Radiation dose
subject: Urinary Tract / Bladder
subject: CT
subject: Diagnostic procedure
subject: Calcifications / Calculi
subject: Workforce

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Purpose: To ascertain if unnecessary scan length in CT KUBs is still occurring at Torbay and South Devon NHS Foundation Trust, ten months after R. Stride and C. Greer performed an audit to call attention to using bony landmarks as a guide in May...
Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis
Creators: name: Brennwald, Patrick
name: Rossi, Guendalina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The yeast type V myosin, Myo2, and the lethal giant larvae homologue, Sro7, are important players in polarized exocytosis. This paper article characterizes the role of Myo2 both in recruiting Sro7 to sites of polarized growth and in negatively regulating a Sec4-dependent vesicle-clustering activity of Sro7.Lgl family members play an important role in the regulation of cell polarity in eukaryotic cells. The yeast homologues Sro7 and Sro77 are thought to act downstream of the Rab GTPase Sec4 to promote soluble N-ethylmaleimide–sensitive factor adaptor protein receptor (SNARE) function in post-Golgi transport. In this article, we characterize the interaction between Sro7 and the type V myosin Myo2 and show that this interaction is important for two distinct aspects of Sro7 function. First, we show that this interaction plays a positive role in promoting the polarized localization of Sro7 to sites of active growth. Second, we find evidence that Myo2 negatively regulates Sro7 function in vesicle clustering. Mutants in either Myo2 or Sro7 that are defective for this interaction show hypersensitivity to Sro7 overexpression, which results in Sec4-dependent accumulation of large groups of vesicles in the cytoplasm. This suggests that Myo2 serves a dual function, to both recruit Sro7 to secretory vesicles and inhibit its Rab-dependent tethering activity until vesicles reach the plasma membrane. Thus Sro7 appears to coordinate the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane.
title: Comparing models of DXA-scanners with different X-ray beam geometry
Creators: name: Artyukova, Zlata
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Bones
subject: Musculoskeletal bone
subject: Musculoskeletal spine
subject: Absorptiometry / Bone densitometry
subject: Efficacy studies
subject: Outcomes analysis
subject: Technology assessment
subject: Demineralisation-Bone
subject: Osteoporosis

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: High-accuracy measurement of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) [1] is considered an important criterion to diagnose osteoporosis and to monitor the treatment progress. The International Society for Clinical...
title: May venous impedance index be more helpful than resistive index in the evaluation of renal obstruction?
Creators: name: Schillirò , Maria Laura
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Emergency
subject: Kidney
subject: Ultrasound physics
subject: Ultrasound
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To demonstrate the correlation between the presence of acute obstructive uropathy and significant decrease in impedance index (II) measured with pulsed Doppler at the level of interlobar...
Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells
Creators: name: Crites, Travis
name: Yi, Jason
name: Hammer III, John A.
name: Wu, Xufeng S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Actin and myosin IIA have been implicated in the inward movement of receptor clusters at the immunological synapse of T lymphocytes. This study defines their spatial organization and quantifies their relative contributions to the dynamics of receptor clusters at the immunological synapse.Actin retrograde flow and actomyosin II contraction have both been implicated in the inward movement of T cell receptor (TCR) microclusters and immunological synapse formation, but no study has integrated and quantified their relative contributions. Using Jurkat T cells expressing fluorescent myosin IIA heavy chain and F-tractin—a novel reporter for F-actin—we now provide direct evidence that the distal supramolecular activation cluster (dSMAC) and peripheral supramolecular activation cluster (pSMAC) correspond to lamellipodial (LP) and lamellar (LM) actin networks, respectively, as hypothesized previously. Our images reveal concentric and contracting actomyosin II arcs/rings at the LM/pSMAC. Moreover, the speeds of centripetally moving TCR microclusters correspond very closely to the rates of actin retrograde flow in the LP/dSMAC and actomyosin II arc contraction in the LM/pSMAC. Using cytochalasin D and jasplakinolide to selectively inhibit actin retrograde flow in the LP/dSMAC and blebbistatin to selectively inhibit actomyosin II arc contraction in the LM/pSMAC, we demonstrate that both forces are required for centripetal TCR microcluster transport. Finally, we show that leukocyte function–associated antigen 1 clusters accumulate over time at the inner aspect of the LM/pSMAC and that this accumulation depends on actomyosin II contraction. Thus actin retrograde flow and actomyosin II arc contraction coordinately drive receptor cluster dynamics at the immunological synapse.
Synthesis of Various N-heterocycles Using the Ugi Four-Center Three-Component Reaction
Creators: name: Heravi, Majid Mommahed
name: Mohammadkhani, Leyla
Publisher: name: figshare
Year: 2020
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30303 Optical Properties of Materials
subject: 30503 Organic Chemical Synthesis
subject: Organic Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry
subject: 39904 Organometallic Chemistry
subject: 30699 Physical Chemistry not elsewhere classified

description: Ugi four‐center three‐component reaction (U‐4 C‐3CR) as actually an important development of the well‐known Ugi four‐component reaction (U‐4CR). In U‐4 C‐3CR, one of the components is bifunctional, reducing the components of U‐4CR to three components. This review aims to provide the application of U‐4 C‐3CR in the synthesis of different N‐heterocyclic compounds with four‐, five‐, six‐, and seven‐membered rings as well as fused heterocycles.
(401584) John Christie Reid
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Centre of mass decoherence due to time dilation: paradoxical frame-dependence
Creators: name: Diósi, Lajos
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The recently proposed centre of mass decoherence of composite objects due to gravitational time-dilation [Pikovski et al., Nat.Phys. 15. June (2015); arXiv:1311.1095] is confronted with the principle of equivalence between gravity and observer's acceleration. In the laboratory frame, a positional superposition $\vert x_1\rangle+\vert x_2\rangle$ can quickly decohere whereas in the free-falling frame, as I argue, the superposition can survive for almost arbitrary long times. The paradoxical result is explained by the so far unappreciated feature of the proposed model: the centre of mass canonical subsystem is ambiguous, it is different in the laboratory and the free-falling frames, respectively. As long as the centre-of-mass motion of the composite object is non-relativistic, a simple Galilean-covariant Hamiltonian represents the Pikovski {\it et al} theory with exactly the same physical predictions. We emphasize the power of this Hamiltonian to understand essential features of the Pikovski {\it et al} theory and to moderate a few divergent statements in recent works.
description: 7pp, Secs.2-4+App.B added; Expanding a topic of invited talk at eighth International Workshop DICE2016 (Castello Pasquini/Castiglioncello/Tuscany, Sept. 12-16, 2016)
title: Imaging features and therapy of chronic pancreatitis vascular complications: A single center experience
Creators: name: Mitrovic, Milica
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Pancreas
subject: Catheter arteriography
subject: CT-Angiography
subject: Ultrasound
subject: Embolisation
subject: Surgery
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Chronic pancreatitis is characterized by recurrent attacks of acute inflammation. Vascular complications are relatively rare, potentially lethal, including venous thrombosis and pseudoaneurysms of arterial blood vessels. Pancreatic enzymes, as well...
A tamper-indicating quantum seal
Creators: name: Williams, Brian P.
name: Britt, Keith A.
name: Humble, Travis S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Technical means for identifying when tampering occurs is a critical part of many containment and surveillance technologies. Conventional fiber optic seals provide methods for monitoring enclosed inventories, but they are vulnerable to spoofing attacks based on classical physics. We address these vulnerabilities with the development of a quantum seal that offers the ability to detect the intercept-resend attack using quantum integrity verification. Our approach represents an application of entanglement to provide guarantees in the authenticity of the seal state by verifying it was transmitted coherently. We implement these ideas using polarization-entangled photon pairs that are verified after passing through a fiber-optic channel testbed. Using binary detection theory, we find the probability of detecting inauthentic signals is greater than 0.9999 with a false alarm chance of $10^{-9}$ for a 10 second sampling interval. In addition, we show how the Hong-Ou-Mandel effect concurrently provides a tight bound on redirection attack, in which tampering modifies the shape of the seal. Our measurements limit the tolerable path length change to sub-millimeter disturbances. These tamper-indicating features of the quantum seal offer unprecedented security for unattended monitoring systems.
description: 9 Pages, 6 Figures
(401585) William Lawson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis
Creators: name: Forsberg, Lawrence J.
name: Alzate, Oscar
name: Onyenwoke, Rob U.
name: Williams, Tyisha
name: Liu, Lucy
name: Brenman, Jay E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Nucleoside diphosphate kinase (NDPK) is a direct target of AMP-activated protein kinase (AMPK) and is inhibited by AMPK-mediated phosphorylation at a conserved serine residue. This serine residue in NDPK is mutated in neuroblastoma, making the enzyme constitutively active.AMP-activated protein kinase (AMPK) is a key energy sensor that regulates metabolism to maintain cellular energy balance. AMPK activation has also been proposed to mimic benefits of caloric restriction and exercise. Therefore, identifying downstream AMPK targets could elucidate new mechanisms for maintaining cellular energy homeostasis. We identified the phosphotransferase nucleoside diphosphate kinase (NDPK), which maintains pools of nucleotides, as a direct AMPK target through the use of two-dimensional differential in-gel electrophoresis. Furthermore, we mapped the AMPK/NDPK phosphorylation site (serine 120) as a functionally potent enzymatic “off switch” both in vivo and in vitro. Because ATP is usually the most abundant cellular nucleotide, NDPK would normally consume ATP, whereas AMPK would inhibit NDPK to conserve energy. It is intriguing that serine 120 is mutated in advanced neuroblastoma, which suggests a mechanism by which NDPK in neuroblastoma can no longer be inhibited by AMPK-mediated phosphorylation. This novel placement of AMPK upstream and directly regulating NDPK activity has widespread implications for cellular energy/nucleotide balance, and we demonstrate in vivo that increased NDPK activity leads to susceptibility to energy deprivation–induced death.
Optomechanically-induced-transparency cooling of massive mechanical resonators to the quantum ground state
Creators: name: Liu, Yong-Chun
name: Xiao, Yun-Feng
name: Luan, Xingsheng
name: Wong, Chee Wei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Ground state cooling of massive mechanical objects remains a difficult task restricted by the unresolved mechanical sidebands. We propose an optomechanically-induced-transparency cooling scheme to achieve ground state cooling of mechanical motion without the resolved sideband condition in a pure optomechanical system with two mechanical modes coupled to the same optical cavity mode. We show that ground state cooling is achievable for sideband resolution $ω_{m}/κ$ as low as 0.003. This provides a new route for quantum manipulation of massive macroscopic devices and high-precision measurements.
description: 6 pages, 5 figures
Elisabetta Fiorini Mazzanti (Terracina, 3 giugno 1799 – Roma, 23 aprile 1879) / Davide Fiorino, Daniele Vergari
Creators: name: Vergari, Daniele
name: Fiorino, Davide
Publisher: name: Zenodo
Year: 2022
Subjects: Accademia dei Georgofili
Fiorini Mazzanti, Elisabetta
Fiorino, Davide
Vergari, Daniele
Biografie
Donne
Scienziate
Pregiudizi

description: Testo originale della Mostra virtuale : Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). Natura: risorsa elettronica. Consistenza: [4] p. Incipit: La seconda figura femminile, in ordine cronologico, ammessa come Socio dei Georgofili è Elisabetta Fiorini, botanica molto nota nel corso del XIX secolo. Nata a Terracina il 3 giugno 1799, fin da giovane manifestò una notevole curiosità verso le piante, spesso raccolte nelle tenute familiari...
description: Digitalizzato come parte della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). https://www.georgofili.it/contenuti/riconoscere-il-merito-superare-i-pregiudizi-scienziate-ai-georgofili-1753-1911-mostra-in-rete/11369
Scalar Singlet Dark Matter and Gamma Lines
Creators: name: Duerr, Michael
name: Perez, Pavel Fileviez
name: Smirnov, Juri
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We point out the possibility to test the simplest scalar dark matter model at gamma-ray telescopes. We discuss the relevant constraints and show the predictions for direct detection, gamma line searches and LHC searches. Since the final state radiation processes are suppressed by small Yukawa couplings one could observe the gamma lines from dark matter annihilation.
description: new references, to appear in Physics Letters B
title: MSK Radiologists- Look out for those non MSK findings on MRI Hip scans!
Creators: name: Dhir, Varun
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Colon
subject: Genital / Reproductive system female
subject: Genital / Reproductive system male
subject: MR
subject: Audit and standards
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: As Musculoskeletal (MSK) radiologists working in tertiary care centres, performing dedicated imaging protocols and reading MRI Hip scans, it can be easy to focus on the osseous details and soft tissue structures in and around the bony pelvis,...
Exploring the Self-enhanced Mechanism of Interactive Advertising Phenomenon---Based on the Research of Three Cases
Creators: name: Ren, Jian
name: Ding, Wanxing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Under the background of the new media era with the rapid development of interactive advertising, this paper used case study method based on the summary of the research of the communication effect of interactive advertising from both domestic and foreign academia. This paper divided interactive advertising into three types to examine ---- interactive ads on official website, interactive ads based on SNS and interactive ads based on mobile media. Furthermore, this paper induced and summarized a self-enhanced dissemination mechanism of the interactive advertising, including three parts which are micro level, meso level and macro level mechanism, micro level embodies core interaction, inner interaction and outer interaction which reveal the whole process of interact with contents, with people and with computer, and the communication approach and spread speed shown in meso level which is self-fission-type spread, finally in macro level the communication effect of IA achieved the spiral increasing. In a word, this article enriches research procedure of the interactive advertising communication effects.
description: 16 pages,10 figures, The International Journal of Multimedia & its Application,2015
title: Role and limitations of cranial ultrasound in the newborn
Creators: name: EL OUALI, Aicha
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: Paediatric
subject: Ultrasound physics
subject: Ultrasound
subject: Diagnostic procedure
subject: Haemorrhage
subject: Infection
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: (1) To revisethe technique of performing cranial ultrasound,(2) To recognize the advantages and disadvantages of this technique.(3) To recognize the normal anatomical structures and the anatomical variants.(4) To know the main pathologies diagnosed...
(401586) Thomas Hunter
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Accretion Processes for General Spherically Symmetric Compact Objects
Creators: name: Bahamonde, Sebastian
name: Jamil, Mubasher
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Category Theory (math.CT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We investigate the accretion process for different spherically symmetric space-time geometries for a static fluid. We analyse this procedure using the most general black hole metric ansatz. After that, we examine the accretion process for specific spherically symmetric metrics obtaining the velocity of the sound during the process and the critical speed of the flow of the fluid around the black hole. In addition, we study the behaviour of the rate of change of the mass for each chosen metric for a barotropic fluid.
description: 10 pages, 15 figures, v2 accepted for publication in 'European Physical Journal C'
title: A Multicentre Retrospective Audit of Coronary Artery Calcification Prevalence on non-ECG gated CT Scans and Analysis of Reporting Rates.
Creators: name: Llewellyn, Oliver
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: Lung
subject: CT
subject: CT-High Resolution
subject: Observer performance
subject: Arteriosclerosis
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Purpose Coronary artery calcification (CAC) is an important marker for coronary heart disease that can be easily identified on computed tomography (CT) scans performed for non-cardiac indications, but is commonly overlooked in radiology reports...
Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase
Creators: name: Huoh, Yu San
name: Hung, Chia Sui
name: Bankaitis, Vytas
name: Stefan, Christopher J.
name: Mousley, Carl J.
name: Ferguson, Kathryn M.
name: Wood, Christopher S.
name: Burd, Christopher G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Signaling by phosphatidylinositol 4-kinases (PI4Ks) in the Golgi apparatus controls lipid homeostasis and protein-sorting pathways. Signaling is shown to be terminated on the medial cisterna by a complex of a PI4K effector, Vps74, and Sac1, the major PtdIns4P phosphatase in the cell.In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a signaling molecule that is recognized by downstream effector proteins. Quantitative analysis of the intra-Golgi distribution of a PtdIns4P reporter protein confirms that PtdIns4P is enriched on the trans-Golgi cisterna, but surprisingly, Vps74 (the orthologue of human GOLPH3), a PI4K effector required to maintain residence of a subset of Golgi proteins, is distributed with the opposite polarity, being most abundant on cis and medial cisternae. Vps74 binds directly to the catalytic domain of Sac1 (KD = 3.8 μM), the major PtdIns4P phosphatase in the cell, and PtdIns4P is elevated on medial Golgi cisternae in cells lacking Vps74 or Sac1, suggesting that Vps74 is a sensor of PtdIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylation of this pool of PtdIns4P. Consistent with the established role of Sac1 in the regulation of sphingolipid biosynthesis, complex sphingolipid homeostasis is perturbed in vps74Δ cells. Mutant cells lacking complex sphingolipid biosynthetic enzymes fail to properly maintain residence of a medial Golgi enzyme, and cells lacking Vps74 depend critically on complex sphingolipid biosynthesis for growth. The results establish additive roles of Vps74-mediated and sphingolipid-dependent sorting of Golgi residents.
The CHY representation of tree-level primitive QCD amplitudes
Creators: name: de la Cruz, Leonardo
name: Kniss, Alexander
name: Weinzierl, Stefan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we construct a CHY representation for all tree-level primitive QCD amplitudes. The quarks may be massless or massive. We define a generalised cyclic factor $\hat{C}(w,z)$ and a generalised permutation invariant function $\hat{E}(z,p,\varepsilon)$. The amplitude is then given as a contour integral encircling the solutions of the scattering equations with the product $\hat{C} \hat{E}$ as integrand. Equivalently, it is given as a sum over the inequivalent solutions of the scattering equations, where the summand consists of a Jacobian times the product $\hat{C} \hat{E}$. This representation separates information: The generalised cyclic factor does not depend on the helicities of the external particles, the generalised permutation invariant function does not depend on the ordering of the external particles.
description: 32 pages, version to be published
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization
Creators: name: Pronobis, Mira I.
name: Poulton, John S.
name: Peifer, Mark
name: Roberts, David M.
name: Kane, Eric G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In this study, we test two current models for the function of the tumor suppressor adenomatous polyposis coli (APC). We find that APC can regulate Wnt signaling from diverse cytoplasmic locations, suggesting that its roles in the nucleus or in localizing the β-catenin destruction complex are not essential.Wnt signaling plays key roles in development and disease. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling. Its best-characterized role is as part of the destruction complex, targeting the Wnt effector β-catenin (βcat) for phosphorylation and ultimate destruction, but several studies suggested APC also may act in the nucleus at promoters of Wnt-responsive genes or to shuttle βcat out for destruction. Even in its role in the destruction complex, APC's mechanism of action remains mysterious. We have suggested APC positions the destruction complex at the appropriate subcellular location, facilitating βcat destruction. In this study, we directly tested APC's proposed roles in the nucleus or in precisely localizing the destruction complex by generating a series of APC2 variants to which we added tags relocalizing otherwise wild-type APC to different cytoplasmic locations. We tested these for function in human colon cancer cells and Drosophila embryos. Strikingly, all rescue Wnt regulation and down-regulate Wnt target genes in colon cancer cells, and most restore Wnt regulation in Drosophila embryos null for both fly APCs. These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling.
Spatially clustered type I interferon responses at injury borderzones
Creators: name: Ninh, Van
Publisher: name: Zenodo
Year: 2024

description: Sterile inflammation after myocardial infarction is classically credited to myeloid cells interacting with dead cell debris in the infarct zone1,2. Here we show that cardiomyocytes are the dominant initiators of a previously undescribed type I interferon response in the infarct borderzone. Using spatial transcriptomics analysis in mice and humans, we find that myocardial infarction induces colonies of interferon-induced cells (IFNICs) expressing interferon-stimulated genes decorating the borderzone, where cardiomyocytes experience mechanical stress, nuclear rupture and escape of chromosomal DNA. Cardiomyocyte-selective deletion of Irf3 abrogated IFNIC colonies, whereas mice lacking Irf3 in fibroblasts, macrophages, neutrophils or endothelial cells, Ccr2-deficient mice or plasmacytoid-dendritic-cell-depleted mice did not. Interferons blunted the protective matricellular programs and contractile function of borderzone fibroblasts, and increased vulnerability to pathological remodelling. In mice that died after myocardial infarction, IFNIC colonies were immediately adjacent to sites of ventricular rupture, while mice lacking IFNICs were protected from rupture and exhibited improved survival3. Together, these results reveal a pathological borderzone niche characterized by a cardiomyocyte-initiated innate immune response. We suggest that selective inhibition of IRF3 activation in non-immune cells could limit ischaemic cardiomyopathy while avoiding broad immunosuppression.
(401580) Alfred Boase
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4
Creators: name: Werner, Michael
name: Goldstein, Bob
name: Tse, Yu Chung
name: Labbe, Jean Claude
name: Longhini, Katrina M.
name: Glotzer, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: RhoA and the Rho guanine nucleotide exchange factor ECT-2 are involved in both polarization and cytokinesis. During cytokinesis, interactions of ECT-2 with the Rho GTPase-activating protein CYK-4 promote RhoA activation. A novel protein, NOP-1, acts in parallel with CYK-4 to promote RhoA activation during polarization and cytokinesis.The GTPase RhoA is a central regulator of cellular contractility in a wide variety of biological processes. During these events, RhoA is activated by guanine nucleotide exchange factors (GEFs). These molecules are highly regulated to ensure that RhoA activation occurs at the proper time and place. During cytokinesis, RhoA is activated by the RhoGEF ECT-2. In human cells, ECT-2 activity requires its association with CYK-4, which is a component of the centralspindlin complex. In contrast, in early Caenorhabditis elegans embryos, not all ECT-2–dependent functions require CYK-4. In this study, we identify a novel protein, NOP-1, that functions in parallel with CYK-4 to promote RhoA activation. We use mutations in nop-1 and cyk-4 to dissect cytokinesis and cell polarization. NOP-1 makes a significant, albeit largely redundant, contribution to cytokinesis. In contrast, NOP-1 is required for the preponderance of RhoA activation during the establishment phase of polarization.
Tracer metadata from Thermotolerant coral–algal mutualisms maintain high rates of nutrient transfer while exposed to heat stress
Creators: name: Kemp, Dustin W.
name: Hoadley, Kenneth D.
name: Lewis, Allison M.
name: Wham, Francis
name: Smith, Robin T.
name: Warner, Mark E.
name: LaJeunesse, Todd C.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology

description: All raw data used for Kemp et al. 2023
On the Oblivious Transfer Capacity of the Degraded Wiretapped Binary Erasure Channel
Creators: name: Mishra, Manoj
name: Dey, Bikash Kumar
name: Prabhakaran, Vinod M.
name: Diggavi, Suhas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: We study oblivious transfer (OT) between Alice and Bob in the presence of an eavesdropper Eve over a degraded wiretapped binary erasure channel from Alice to Bob and Eve. In addition to the privacy goals of oblivious transfer between Alice and Bob, we require privacy of Alice and Bob's private data from Eve. In previous work we derived the OT capacity (in the honest-but-curious model) of the wiretapped binary independent erasure channel where the erasure processes of Bob and Eve are independent. Here we derive a lower bound on the OT capacity in the same secrecy model when the wiretapped binary erasure channel is degraded in favour of Bob.
description: To be presented at the IEEE International Symposium on Information Theory (ISIT 2015), Hong Kong
Tension-dependent nucleosome remodeling at the pericentromere in yeast
Creators: name: Yeh, Elaine
name: Verdaasdonk, Jolien S.
name: Bloom, Kerry
name: Stephens, Andrew D.
name: Gardner, Ryan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Dynamics of histones under tension in the pericentromere depends on RSC and ISW2 chromatin remodeling. The underlying pericentromeric chromatin forms a platform that is required to maintain kinetochore structure when under spindle-based tension.Nucleosome positioning is important for the structural integrity of chromosomes. During metaphase the mitotic spindle exerts physical force on pericentromeric chromatin. The cell must adjust the pericentromeric chromatin to accommodate the changing tension resulting from microtubule dynamics to maintain a stable metaphase spindle. Here we examine the effects of spindle-based tension on nucleosome dynamics by measuring the histone turnover of the chromosome arm and the pericentromere during metaphase in the budding yeast Saccharomyces cerevisiae. We find that both histones H2B and H4 exhibit greater turnover in the pericentromere during metaphase. Loss of spindle-based tension by treatment with the microtubule-depolymerizing drug nocodazole or compromising kinetochore function results in reduced histone turnover in the pericentromere. Pericentromeric histone dynamics are influenced by the chromatin-remodeling activities of STH1/NPS1 and ISW2. Sth1p is the ATPase component of the Remodels the Structure of Chromatin (RSC) complex, and Isw2p is an ATP-dependent DNA translocase member of the Imitation Switch (ISWI) subfamily of chromatin-remodeling factors. The balance between displacement and insertion of pericentromeric histones provides a mechanism to accommodate spindle-based tension while maintaining proper chromatin packaging during mitosis.
(401582) George O'Farrell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401583) James Balmain
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Network science based quantification of resilience demonstrated on the Indian Railways Network
Creators: name: Bhatia, Udit
name: Kumar, Devashish
name: Kodra, Evan
name: Ganguly, Auroop R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: The structure, interdependence, and fragility of systems ranging from power grids and transportation to ecology, climate, biology and even human communities and the Internet, have been examined through network science. While the response to perturbations has been quantified, recovery strategies for perturbed networks have usually been either discussed conceptually or through anecdotal case studies. Here we develop a network science-based quantitative methods framework for measuring, comparing and interpreting hazard responses and as well as recovery strategies. The framework, motivated by the recently proposed temporal resilience paradigm, is demonstrated with the Indian Railways Network. The methods are demonstrated through the resilience of the network to natural or human-induced hazards and electric grid failure. Simulations inspired by the 2004 Indian Ocean Tsunami and the 2012 North Indian blackout as well as a cyber-physical attack scenario. Multiple metrics are used to generate various recovery strategies, which are simply sequences in which system components should be recovered after a disruption. Quantitative evaluation of recovery strategies suggests that faster and more resource-effective recovery is possible through network centrality measures. Case studies based on two historical events, specifically the 2004 Indian Ocean tsunami and the 2012 North Indian blackout, and a simulated cyber-physical attack scenario, provides means for interpreting the relative performance of various recovery strategies. Quantitative evaluation of recovery strategies suggests that faster and more resource-effective restoration is possible through network centrality measures, even though the specific strategy may be different for sub-networks or for the partial recovery.
title: To what extent does pineapple juice have a positive influence on image quality during a MRCP examination?
Creators: name: Gilani, Warda
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Biliary Tract / Gallbladder
subject: Radiographers
subject: MR-Cholangiography
subject: Contrast agent-oral
subject: Artifacts
subject: Obstruction / Occlusion

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Magnetic Resonance Cholangiopancreatography (MRCP) is a noninvasive imaging technique to visualize the biliary tree and the pancreatic ductal system. The technique used for this examination is based on heavy T2 weighted sequences, allowing only...
(401581) George Omond
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Exploring the Quantum Speed Limit with Computer Games
Creators: name: Sørensen, Jens Jakob W. H.
name: Pedersen, Mads Kock
name: Munch, Michael
name: Haikka, Pinja
name: Jensen, Jesper Halkjær
name: Planke, Tilo
name: Andreasen, Morten Ginnerup
name: Gajdacz, Miroslav
name: Mølmer, Klaus
name: Lieberoth, Andreas
name: Sherson, Jacob F.
name: players, Quantum Moves
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Humans routinely solve problems of immense computational complexity by intuitively forming simple, low-dimensional heuristic strategies. Citizen science exploits this ability by presenting scientific research problems to non-experts. Gamification is an effective tool for attracting citizen scientists to provide solutions to research problems. While citizen science games Foldit, EteRNA and EyeWire have been used successfully to study protein and RNA folding and neuron mapping, so far gamification has not been applied to problems in quantum physics. Does the fact that everyday experiences are based on classical physics hinder the use of non-expert citizen scientists in the realm of quantum mechanics? Here we report on Quantum Moves, an online platform gamifying optimization problems in quantum physics. We show that human players are able to find solutions to difficult problems associated with the task of quantum computing. Players succeed where purely numerical optimization fails, and analyses of their solutions provide insights into the problem of optimization of a more profound and general nature. Based on player strategies, we have thus developed a new, few-parameter heuristic optimization method which efficiently outperforms the most prominent established numerical methods. The numerical complexity associated with time-optimal solutions increases for shorter process durations. To better understand this, we have made a low-dimensional rendering of the optimization landscape. These studies show why traditional optimization methods fail near the quantum speed limit, and they bring promise that combined analyses of optimization landscapes and heuristic solution strategies may benefit wider classes of optimization problems in quantum physics and beyond.
description: 19 pages, 7 figures, supplementary materials are included
The coupling between sister kinetochore directional instability and oscillations in centromere stretch in metaphase PtK1 cells
Creators: name: Wan, Xiaohu
name: Cameron, Lisa A.
name: Cimini, Daniela
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: High-resolution kinetochore tracking reveals that oscillations in centromere stretch occur at twice the frequency of kinetochore oscillations because of the nonlinear kinetics of kinetochore directional instability, which produce poleward and away-from-the-pole kinetochore oscillations.Kinetochores bound to kinetochore microtubules (kMTs) exhibit directional instability in mammalian and other mitotic vertebrate cells, oscillating between poleward (P) and away-from-the-pole (AP) movements. These oscillations are coupled to changes in length of kMTs in a way that maintains a net stretch of the centromere. To understand how sister kinetochore directional instability and kMT plus-end dynamic instability are coupled to oscillations in centromere stretch, we tracked at high resolution the positions of fluorescent kinetochores and their poles for oscillating chromosomes within spindles of metaphase PtK1 cells. We found that the kinetics of P and AP movement are nonlinear and different. By subtracting contributions from the poleward flux of kMTs, we found that maximum centromere stretch occurred when the leading kinetochore switched from depolymerization to polymerization, whereas minimum centromere stretch occurred on average 7 s after the initially trailing kinetochore switched from polymerization to depolymerization. These differences produce oscillations in centromere stretch at about twice the frequency of kinetochore directional instability and at about twice the frequency of centromere oscillations back and forth across the spindle equator.
Analyse du niveau de risque des activités illégales dans les UFAs de la Région de l'Est au Cameroun (cas de la SEBAC et de la Filière Bois)
Creators: name: Saague, E.
name: Foudjet, A.E.
name: Gweth, L.R.
Publisher: name: Zenodo
Year: 2020
Subjects: Activité illégale
braconnage
droit d'usage
exploitation forestière
exploitation minière

description: 1. Objectif Général (OG)
 Analyser le niveau de risque des activités illégales dans l’Unité Forestière d'Aménagement (UFA) 10009 appartenant à la Société d'Exploitation de BOIS d'Afrique Centrale (SEBAC) et l’UFA 10064 appartenant à la Filière Bois.
 2. Objectifs spécifiques (OS)
 OS1 : Analyser l’état des lieux des activités menées dans les concessions Forestières de la SEBAC et de la Filière Bois ;
 OS2 : Evaluer les mesures préventives mises en place pour limiter les activités illégales dans leurs concessions forestières ;
 OS3 : Proposer des stratégies de limitation de risques.
 3. Hypothèse Générale (HG)
 Le niveau de risque des activités illégales est connu et a été réduit grâce au renforcement des mesures préventives en place. 4. Hypothèse Spécifiques (HS)
 H1 : Les activités exercées dans les UFA et leurs périphéries compromettent la gestion durable de ces UFA;
 H2 : Les mesures préventives mises en place par la SEBAC et de la Filière Bois pour sécuriser leurs concessions forestières connaissent quelques insuffisances ;
 H3 : La SEBAC et l’entreprise Filière Bois possèdent des stratégies de surveillance pas assez efficaces pour limiter les risques d’activités illégales dans leurs UFA.