title: ÐÐ¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ¸, Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð·Ð° Ð¸Ð½Ð¸ÑÐ¸Ð°ÑÐ¸Ñ ÑÐ²ÐµÑÐµÐ½Ð¸Ñ Ñ Ð³Ð¾ÑÐ¾Ñ Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Modeling the gene network responsible for the initiation of flowering in pea
Creators: name: ÐÐ°Ð²Ð»Ð¸Ð½Ð¾Ð²Ð°, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð±Ð¾Ð±Ð¾Ð²ÑÐµ
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Ð³ÐµÐ½Ð½Ð°Ñ ÑÐµÑÑ
Ð¸Ð½Ð¸ÑÐ¸Ð°ÑÐ¸Ñ ÑÐ²ÐµÑÐµÐ½Ð¸Ñ
ÑÐ¾ÑÐ¾Ð¿ÐµÑÐ¸Ð¾Ð´
Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÐµ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ
Ð»Ð¸Ð½ÐµÐ¹Ð½Ð°Ñ ÑÐµÐ³ÑÐµÑÑÐ¸Ñ
Ð½ÐµÐ¹ÑÐ¾Ð½Ð½Ð°Ñ ÑÐµÑÑ
bean
pea
gene network
flowering initiation
photo period
differential equations
linear regression
neural network

description: Ð¦ÐµÐ»ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÐ»ÑÑ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ¸ Ð¿ÐµÑÐµÑÐ¾Ð´Ð° Ðº ÑÐ²ÐµÑÐµÐ½Ð¸Ñ Ñ Ð³Ð¾ÑÐ¾ÑÐ° (Pisum sativum) Ð¿ÑÑÐµÐ¼ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ðº Ð´Ð°Ð½Ð½ÑÐ¼ Ð¿Ð¾ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð². Ð ÑÐ°Ð±Ð¾ÑÐµ ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹, Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð½Ð° Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð¹ ÑÐ°Ð½ÐµÐµ ÑÑÐµÐ¼Ðµ Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ Ð¸Ð½Ð¸ÑÐ¸Ð°ÑÐ¸Ð¸ ÑÐ²ÐµÑÐµÐ½Ð¸Ñ Ð³Ð¾ÑÐ¾ÑÐ°. Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½ÑÐµ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ, Ð¼ÐµÑÐ¾Ð´ Ð»Ð¸Ð½ÐµÐ¹Ð½Ð¾Ð¹ ÑÐµÐ³ÑÐµÑÑÐ¸Ð¸ Ð¸ Ð½ÐµÐ¹ÑÐ¾Ð½Ð½ÑÐµ ÑÐµÑÐ¸. ÐÐ¾Ð´ÐµÐ»Ð¸ Ð²ÐµÑÐ¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð»Ð¸ÑÑ Ð½Ð° ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¿Ð¾ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÑ Ð³ÐµÐ½Ð¾Ð² Ð² Ð´Ð¸ÐºÐ¾Ð¼ ÑÐ¸Ð¿Ðµ Ð¸ Ð² ÑÑÐµÑ Ð¼ÑÑÐ°Ð½ÑÐ½ÑÑ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð°Ñ. ÐÑÐ»Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ñ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ Ð³Ð¸Ð¿Ð¾ÑÐµÐ· Ð¾ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÑ Ð°Ð»ÑÑÐµÑÐ½Ð°ÑÐ¸Ð²Ð½ÑÑ ÑÐµÐ³ÑÐ»ÑÑÐ¾ÑÐ½ÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸ÑÑ Ð¼ÐµÐ¶Ð´Ñ Ð³ÐµÐ½Ð°Ð¼Ð¸. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð±ÑÐ»Ð¸ ÑÐ´ÐµÐ»Ð°Ð½Ñ Ð²ÑÐ²Ð¾Ð´Ñ Ð¾ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾ÑÑÐ¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÑ ÑÐ°Ð½ÐµÐµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ Ð² Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ¸ Ð¸ Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ð¸ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÑÐ»Ð¾Ð²Ð¸Ð¹ Ð²ÑÑÐ°ÑÐ¸Ð²Ð°Ð½Ð¸Ñ Ð½Ð° Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÑ ÑÐµÑÐ¸. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ ÑÐµÐ³ÑÐ»ÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² PIM, FTa1 Ð¸ FTc Ð² Ð³Ð¾ÑÐ¾ÑÐµ Ð½Ðµ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÐ¼ ÑÐ°Ð½ÐµÐµ Ð³Ð¸Ð¿Ð¾ÑÐµÐ·Ð°Ð¼. ÐÑÐ´Ð²Ð¸Ð½ÑÑÐ° Ð³Ð¸Ð¿Ð¾ÑÐµÐ·Ð° Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ ÑÑÐ»Ð¾Ð²Ð¸Ñ ÐºÐ¾ÑÐ¾ÑÐºÐ¾Ð³Ð¾ Ð¸ Ð´Ð»Ð¸Ð½Ð½Ð¾Ð³Ð¾ Ð´Ð½Ñ Ð² ÑÐ¾Ð´Ðµ Ð²ÑÑÐ°ÑÐ¸Ð²Ð°Ð½Ð¸Ñ Ð³Ð¾ÑÐ¾ÑÐ° ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÑÑÑÑ ÑÐ°Ð·Ð½Ð¾Ð¹ Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÐ¾Ð¹ Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ¸ Ð¿ÐµÑÐµÑÐ¾Ð´Ð° Ðº ÑÐ²ÐµÑÐµÐ½Ð¸Ñ. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð´Ð»Ñ Ð°Ð´ÐµÐºÐ²Ð°ÑÐ½Ð¾Ð³Ð¾ ÑÑÐµÑÐ° Ð³Ð¾Ð¼Ð¾Ð»Ð¾Ð³Ð¾Ð² ÑÐ²ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÐµÐ¿ÑÐµÑÑÐ¾ÑÐ° TFL1 Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð° Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ Ð² Ð´Ð°Ð½Ð½ÑÑ Ð¸ Ð¼Ð¾Ð´ÐµÐ»ÑÑ. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð½Ð¾Ð²ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð² Ð¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð±Ð¾Ð»ÐµÐµ ÑÐ¾ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸Ð½Ð¸ÑÐ¸Ð°ÑÐ¸Ð¸ ÑÐ²ÐµÑÐµÐ½Ð¸Ñ Ñ Ð³Ð¾ÑÐ¾ÑÐ° Ð¸, Ð² Ð±Ð¾Ð»ÐµÐµ ÑÐ¸ÑÐ¾ÐºÐ¾Ð¼ ÐºÐ¾Ð½ÑÐµÐºÑÑÐµ, Ñ Ð±Ð¾Ð±Ð¾Ð²ÑÑ.
description: The main goal of the study was a quantitative analysis of the gene network of the flowering initiation in pea (Pisum sativum) by applying various modeling methods to gene expression data. In the paper has been formulated several mathematical models based on the previously proposed scheme of gene regulation of the initiation of flowering in pea. As modeling methods, differential equations, linear regression method and neural networks were used. Models were verified using experimental the dynamic expression data of major genes in the wild type of pea and in three mutant genotypes. Several hypotheses about possible alternative regulatory interactions between genes have been tested. The analysis led to conclusions on the functionality of the early described interactions in the gene network and the influence of various growing conditions on the network architecture. It was shown that the regulation of the PIM, FTa1, and FTc genes in pea does not correspond to the previously proposed hypotheses. It has been hypothesized that the short- and long-day conditions during pea cultivation are characterized by different architecture of the gene network controlling transition to flowering. Spatial information in data and models has been required to adequately account for flower repressor TFL1 homologues. The results can be used to plan new experiments and create more accurate models in the field of studying the initiation of flowering in pea and, in a wider context, in legumes.