cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Polarization Pursuers' Guide
Creators: name: Jaffe, Andrew H.
name: Kamionkowski, Marc
name: Wang, Limin
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We calculate the detectability of the polarization of the cosmic microwave background (CMB) as a function of the sky coverage, angular resolution, and instrumental sensitivity for a hypothetical experiment. We consider the gradient component of the polarization from density perturbations (scalar modes) and the curl component from gravitational waves (tensor modes). We show that the amplitude (and thus the detectability) of the polarization from density perturbations is roughly the same in any model as long as the model fits the big-bang-nucleosynthesis (BBN) baryon density and degree-scale anisotropy measurements. The degree-scale polarization is smaller (and accordingly more difficult to detect) if the baryon density is higher. In some cases, the signal-to-noise for polarization (both from scalar and tensor modes) may be improved in a fixed-time experiment with a smaller survey area.
description: 18 pages, 6 figures
Additional file 4: of Comparative root transcriptome of wild Arachis reveals NBS-LRR genes related to nematode resistance
Creators: name: Mota, Ana
name: Vidigal, Bruna
name: Danchin, Etienne
name: Togawa, Roberto
name: Leal-Bertioli, Soraya
name: Bertioli, David
name: Araujo, Ana
name: Brasileiro, Ana
name: Guimaraes, Patricia
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Figure S2. Transcriptional profile of members of four TF families: (A) WRKY (B) MYB (C) bZIP (D) ERF in A. stenosperma (SN3, SN6, SN9) and A. duranensis (DN3, DN6, DN9) in response to RKN infection. (PDF 1356 kb)
Yielding of a Model Glassformer: an Interpretation with an Effective System of Icosahedra
Creators: name: Pinney, Rhiannon
name: Liverpool, Tanniemola B.
name: Royall, C. Patrick
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We consider the yielding under simple shear of a binary Lennard-Jones glassformer whose super-Arrhenius dynamics are correlated with the formation of icosahedral structures. We recast this glassformer as an effective system of icosahedra [Pinney et al. J. Chem. Phys. 143 244507 (2015)]. Looking at the small-strain region of sheared simulations, we observe that shear rates affect the shear localisation behavior particularly at temperatures below the glass transition as defined with a fit to the Vogel-Fulcher-Tamman equation. At higher temperature, shear localisation starts immediately upon shearing for all shear rates. At lower temperatures, faster shear rates can result in a delayed start in shear localisation; which begins close to the yield stress. Building from a previous work which considered steady-state shear [Pinney et al. J. Chem. Phys. 143 244507 (2016)], we interpret the response to shear and the shear localisation in terms of a \emph{local} effective temperature with our system of icosahedra. We find that the effective temperatures of the regions undergoing shear localisation increase significantly with increasing strain (before reaching a steady state plateau).
description: 13 pages, accepted in Phys. Rev. E
Foundations of the self-force problem in arbitrary dimensions
Creators: name: Harte, Abraham I.
name: Taylor, Peter
name: Flanagan, Éanna É.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The self-force problem---which asks how self-interaction affects a body's motion---has been poorly studied for spacetime dimensions $d \neq 4$. We remedy this for all $d \geq 3$ by nonperturbatively constructing momenta such that forces and torques acting on extended, self-interacting electromagnetic charges have the same functional forms as their test body counterparts. The electromagnetic field which appears in the resulting laws of motion is not however the physical one, but a certain effective surrogate which we derive. For even $d\geq 4$, explicit momenta are identified such that this surrogate field satisfies the source-free Maxwell equations; laws of motion in these cases can be obtained similarly to those in the well-known four-dimensional Detweiler-Whiting prescription. For odd $d$, no analog of the Detweiler-Whiting prescription exists. Nevertheless, we derive its replacement. These general results are used to obtain explicit point-particle self-forces and self-torques in Minkowski spacetimes with various dimensions. Among various characteristics of the resulting equations, perhaps the most arresting is that an initially-stationary charge which is briefly kicked in 2+1 dimensions asymptotically returns to rest.
description: 30 pages, 1 figure
Pinwheel nebula around WR 98a
Creators: name: Monnier, J. D.
name: Tuthill, P. G.
name: Danchi, W. C.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the first near-infrared images of dusty Wolf-Rayet star WR 98a. Aperture masking interferometry has been utilized to recover images at the diffraction-limit of the Keck-I telescope, ~<50 mas at 2.2 micron. Multi-epoch observations spanning about one year have resolved the dust shell into a ``pinwheel'' nebula, the second example of a new class of dust shell first discovered around WR 104 (Tuthill, Monnier, & Danchi 1999a). Interpreting the collimated dust outflow in terms of an interacting winds model, the binary orbital parameters and apparent wind speed are derived: a period of 565 +/- 50 days, a viewing angle of 35 +/- 6 degrees from the pole, and a wind speed of 99 +/- 23 mas/yr. This period is consistent with a possible ~588 day periodicity in the infrared light curve (Williams et al. 1995), linking the photometric variation to the binary orbit. Important implications for binary stellar evolution are discussed by identifying WR 104 and WR 98a as members of a class of massive, short-period binaries whose orbits were circularized during a previous red supergiant phase. The current component separation in each system is similar to the diameter of a red supergiant, indicating that the supergiant phase was likely terminated by Roche-lobe overflow, leading to the present Wolf-Rayet stage.
description: Accepted in ApJ Letters (4 pages, 2 figures, 1 table); latex style files: epsfig, emulateapj
Vanilla pfaviana Rchb. f.
Creators: name: Damián-Parizaca, Alexander
name: Karremans, Adam P.
name: Mitidieri-Rivera-Rivera, Nicole
name: Cameron, Kenneth M.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Vanilla
Vanilla pfaviana

description: 23.Vanilla pfavianaRchb. f. (Reichenbach 1883: 230)
Type.
COSTA RICA • “ Mexico ”; R. Pfau 269; holotype: W!, AMES! [00090736] sketch, K! [K 001784688] photograph.
Notes.
The paper in which Reichenbach published this species explicitly states he is basing it solely on a sketch received from Pfau (Reichenbach 1883). There is a single sketch in his herbarium matching the protologue, and it is determined as ‘ Pfaviana’ in the author’s own handwriting. We find this sufficient to unambiguously determine it as the holotype.
description: Published as part of Damián-Parizaca, Alexander, Karremans, Adam P., Mitidieri-Rivera-Rivera, Nicole & Cameron, Kenneth M., 2025, Towards a monograph of membranaceous Vanillas: a nomenclatural revision of Vanilla subgen. Vanilla (Vanilloideae, Orchidaceae), pp. 111-121 in Plant Ecology and Evolution 158 (1) on pages 111-121, DOI: 10.5091/plecevo.140667
Anomalous quartic couplings in $ W^+W^- γ$ production at $e^+e^- $ colliders
Creators: name: Leil, Ghadir Abu
name: Stirling, W. J.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the process $e^+e^- \rightarrow W^+W^- γ$ at high-energy $e^+ e^-$ colliders to investigate the effect of genuine quartic $W^+W^-γγ$ and $W^+W^- Zγ$ anomalous couplings on the cross section. Deviations from the Standard Model predictions are quantified. We show how bounds on the anomalous couplings can be improved by choosing specific initial state helicity combinations. The dependence of the anomalous contributions on the collider energy is studied.
description: 15 pages, DTP/94/10
Precision Timing of Two Anomalous X-Ray Pulsars
Creators: name: Kaspi, Victoria M.
name: Chakrabarty, Deepto
name: Steinberger, Julia
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on long-term X-ray timing of two anomalous X-ray pulsars, 1RXS J170849.0-400910 and 1E 2259+586, using the Rossi X-ray Timing Explorer. In monthly observations made over 1.4 yr and 2.6 yr for the two pulsars, respectively, we have obtained phase-coherent timing solutions which imply that these objects have been rotating with great stability throughout the course of our observations. For 1RXS J170849.0-400910, we find a rotation frequency of 0.0909169331(5) Hz and frequency derivative -15.687(4) x 10^(-14) Hz/s, for epoch MJD 51215.931. For 1E 2259+586, we find a rotation frequency of 0.1432880613(2)Hz, and frequency derivative -1.0026(7) x 10^(-14) Hz/s, for epoch MJD 51195.583. RMS phase residuals from these simple models are only about 0.01 cycles for both sources. We show that the frequency derivative for 1E 2259+586 is inconsistent with that inferred from incoherent frequency observations made over the last 20 yr. Our observations are consistent with the magnetar hypothesis and make binary accretion scenarios appear unlikely.
description: 12 pages including 3 figures. To appear in ApJ Letters
A complete sample of LSP blazars fully described in $γ$-rays. New $γ$-ray detections and associations with Fermi-LAT
Creators: name: Arsioli, B.
name: Polenta, G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the $γ$-ray and broadband spectral energy distribution (SED) properties of a complete sample of 104 bright, radio-selected low-synchrotron peaked (LSP) blazars. Most of the sources have already been detected in the $γ$-ray band by Fermi-LAT, however almost 20% of these blazars have no counterpart in any of the Fermi catalogs so far. Using the Fermi Science Tools, we look for $γ$-ray emission for those objects not yet reported in any Fermi-LAT catalog. We performed a binned likelihood analysis in the 0.3-500 GeV energy band with Fermi-LAT Pass 8 data, integrating over 7.5 years of observations. We studied $γ$-ray light curves and test statistic (TS) maps to validate new detections and associations. We fit the synchrotron (Syn) and inverse Compton (IC) components for all sources using all available historical data, enhancing the study of Syn to IC peak-power correlations. We derive the distribution of the Compton dominance (CD) along with population properties such as Syn and IC peak power, and frequency distributions. We deliver a unique characterization in $γ$-rays for a complete sample of LSP blazars. We show that three previously unidentified 3FGL sources can be associated with blazars when using improved $γ$-ray positions obtained from TS maps. Six previously unreported $γ$-ray sources are detected at TS>20 level, while another three show TS values between 10-20. We evaluate two cases in which source confusion is likely present. In four cases there is no significant $γ$-ray signature, however short-lived flares have been detected in these sources. Finally, the log(CD) has a Gaussian-like distribution with median log(CD)=0.1, implying that on average the peak-power for the Syn and IC components in LSP blazars are similar.
description: 19 pages, 24 figures, Accepted for publication in A&A
The Free Energy of Hot QED at Fifth Order
Creators: name: Parwani, Rajesh R.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The order $e^5$ contribution to the pressure of massless quantum electrodynamics at nonzero temperature is determined explicitly. An identity is also obtained relating a gauge-invariant piece of the pressure at order $e^{2n+3} \ (n \ge 1) $ (from diagrams with only one fermion loop) to the pressure at order $e^{2n}$.
description: 1+9+1 pages (figures attached as .ps file after end{document}); preprint SPhT/94-065
Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis
Creators: name: Liu, M
name: Wang, M
name: Huang, L
name: Tan, J
name: Hu, M
name: Wang, Y
name: Liu, Z
name: Yu, Z
name: Guan, K
Publisher: name: Nature Research
Year: 2021

description: Relaxin is an antifibrotic peptide hormone previously assumed to directly reverse the activation of hepatic stellate cells for liver fibrosis resolution. Using nanoparticle-mediated delivery, here we show that, although relaxin gene therapy reduces liver fibrosis in vivo, in vitro treatment fails to induce quiescence of the activated hepatic stellate cells. We show that hepatic macrophages express the primary relaxin receptor, and that, on relaxin binding, they switch from the profibrogenic to the pro-resolution phenotype. The latter releases exosomes that promote the relaxin-mediated quiescence of activated hepatic stellate cells through miR-30a-5p. Building on these results, we developed lipid nanoparticles that preferentially target activated hepatic stellate cells in the fibrotic liver and encapsulate the relaxin gene and miR-30a-5p mimic. The combinatorial gene therapy achieves synergistic antifibrosis effects in models of mouse liver fibrosis. Collectively, our findings highlight the key role that macrophages play in the relaxin-primed alleviation of liver fibrosis and demonstrate a proof-of-concept approach to devise antifibrotic strategies through the complementary application of nanotechnology and basic science.
Образовательный кластер как форма социального партнерства (на примере Сухоложского многопрофильного техникума)
Creators: name: Зырянова Наталья Искандарьевна
name: Маскина Ольга Геннадьевна
name: Фоменко Ирина Владимировна
Publisher: name: Профессиональное образование и рынок труда
Year: 2019
Subjects: образовательный кластер
качество профессионального образования
подготовка кадров
социальное партнерство
рынок труда
educational cluster
quality of professional education
training
social partnership
labor market

description: Статья посвящена созданию образовательного кластера на базе Сухоложского многопрофильного техникума, основанного на взаимодействии «школа — техникум — вуз — предприятие — муниципалитет». Материал имеет практическую значимость для специалистов, осуществляющих реализацию проектов и программ в рамках партнерских отношений не только среди образовательных организаций СПО, но и предприятий, общеобразовательных школ
description: The article is devoted to the creation of an educational cluster on the basis of the Sukholozhsky Multidisciplinary College, based on the interaction «school — College — University — enterprise — municipality». The material is of practical importance for specialists implementing projects and programs within the framework of partnerships not only among educational organizations of the SPO, but also enterprises, secondary schools.
Madrepora favosa Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Oculinidae
Madrepora
Madrepora favosa

description: Madrepora favosa [spec. nov.]
M. composita, stellis angulosis concavis coadunatis. Amoen. acad. 1. p. 96. t. 4. f. XVI.
Bocc. mus. 1. t. 5. f. 3. Astroites.
Habitat .. fossilis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 796, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Driving Scene Perception Network: Real-time Joint Detection, Depth Estimation and Semantic Segmentation
Creators: name: Chen, Liangfu
name: Yang, Zeng
name: Ma, Jianjun
name: Luo, Zheng
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: As the demand for enabling high-level autonomous driving has increased in recent years and visual perception is one of the critical features to enable fully autonomous driving, in this paper, we introduce an efficient approach for simultaneous object detection, depth estimation and pixel-level semantic segmentation using a shared convolutional architecture. The proposed network model, which we named Driving Scene Perception Network (DSPNet), uses multi-level feature maps and multi-task learning to improve the accuracy and efficiency of object detection, depth estimation and image segmentation tasks from a single input image. Hence, the resulting network model uses less than 850 MiB of GPU memory and achieves 14.0 fps on NVIDIA GeForce GTX 1080 with a 1024x512 input image, and both precision and efficiency have been improved over combination of single tasks.
description: 9 pages, 7 figures, WACV'18
Additional file 1: of The economic burden of cardiovascular disease and hypertension in low- and middle-income countries: a systematic review
Creators: name: Gheorghe, Adrian
name: Griffiths, Ulla
name: Murphy, Adrianna
name: Legido-Quigley, Helena
name: Lamptey, Peter
name: Perel, Pablo
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Computational Biology

description: Search strategies for the included databases. (DOCX 54 kb)
X-rays from the Highly Polarized Broad Absorption Line QSO CSO 755
Creators: name: Brandt, W. N.
name: Comastri, A.
name: Gallagher, S. C.
name: Sambruna, R. M.
name: Boller, Th.
name: Laor, A.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present results from a BeppoSAX observation of the BAL QSO CSO 755, observed as part of our program to investigate the X-ray properties of highly polarized BAL QSOs. CSO 755 is clearly detected by the BeppoSAX MECS, making it the highest redshift (z=2.88) and most optically luminous (M_V=-27.4) BAL QSO seen in X-rays. It is detected in several energy bands including the rest-frame 21-39 keV band, but we are only able to place loose constraints upon its X-ray spectral shape. Our X-ray detection is consistent with the hypothesis that the BAL QSOs with high optical continuum polarization tend to be the X-ray brighter members of the class. We examine a scattering interpretation of a polarization/X-ray flux connection, and we discuss the data needed to prove or refute such a connection. We also discuss a probable ROSAT detection of CSO 755. The observed-frame 2-10 keV flux from BeppoSAX (1.3 x 10^{-13} erg cm^{-2} s^{-1}) is high enough to allow XMM spectroscopy, and studies of iron K line emission should prove of particular interest if a large amount of scattered X-ray flux is present.
description: 13 pages, ApJL accepted, also available from http://www.astro.psu.edu/users/niel/papers/papers.html
Madrepora organu Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Oculinidae
Madrepora
Madrepora organu

description: Madrepora organu [spec. nov.]
M. composita, cylindris striatis membrana deflexa striata combinatis.
Amoen. acad. 1. p. 96. t. 4. f. 6: 1. Madrepora composita, corporibus proliferis e centro solitariis, membrana reflexa coadunatis stellatis.
Habitat .. fossilis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 796, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release
Creators: name: Chen G.-Y
name: McKnight K.L
name: Shiota T
name: Li Z
name: Shirasaki T
name: Sheahan T.P
name: Muramatsu M
name: Kapustina M
name: Zhang Q
name: Lemon S.M
name: Cameron C.E
name: Li Y
name: Yonish B
name: Kim H
name: Fritch E.J
Publisher: name: American Association for the Advancement of Science
Year: 2023

description: Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells and purified extracellular quasi-enveloped virions with high-throughput RNA sequencing and genetic depletion studies, we show that hepatitis A virus, an hepatotropic picornavirus, broadly manipulates the host cell lipid environment, enhancing synthesis of ceramides and other sphingolipids and transcriptionally activating acyl–coenzyme A synthetases and fatty acid elongases to import and activate long-chain fatty acids for entry into the fatty acid elongation cycle. Phospholipids with very-long-chain acyl tails (>C22) are essential for genome replication, whereas increases in sphingolipids support assembly and release of quasi-enveloped virions wrapped in membranes highly enriched for sphingomyelin and very-long-chain ceramides. Our data provide insight into how a pathogenic virus alters lipid flux in infected hepatocytes and demonstrate a distinction between lipid species required for viral RNA synthesis versus nonlytic quasi-enveloped virus release.
The broad Fe K line profile in NGC 4151
Creators: name: Wang, Junxian.
name: Zhou, Youyuan.
name: Wang, Tinggui.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present an analysis of the Fe K line profile of NGC 4151 by using long ASCA observation data obtained in May 1995. The unprecedented good data quality, which is much better in the energy band around 6.4 keV than that of the famous 4.2-day ASCA observation of MCG -6-30-15 in July 1994, offers a unique opportunity to study the details of Fe K line profile. Apart from those characteristics already noticed in earlier ASCA observations on this object (Yaqoob et al. 1995): a broad and skewed profile, with a strong peak at about 6.4 keV and a large red wing extending to $\sim$4 - 5 keV, which is remarkably similar to that of MCG -6-30-15, we also find a weak blue wing extending to about 8 keV, thanks to the good quality of the data. When fitted by a relativistic accretion disk line plus a narrow core at 6.4 keV, the data constrain the accretion disk to be nearly face-on, contrary to the edge-on geometry inferred from optical and UV observations. However, the extended blue wing can not be well fitted even after we include corresponding Fe K$β$ components. Ni K$α$ line emission by an amount of 12% of Fe K$α$ is statistically required. An alternative explanation is a model consisting of a narrow core and two disk lines with inclinations of 58$^{\rm o}$ and 0$^{\rm o}$, respectively. We suppose that the component with inclination of 58$^{\rm o}$ was observed directly, consistent with its edge-on geometry, and the component with inclination of 0$^{\rm o}$ was scattered into our line of sight by a Compton mirror, which might be the cool accretion disk corona proposed by Poutanen et al. (1996).
description: 15 pages, including 2 figures, aasms4.sty. To appear in ApJL 523
HER2DX genomic test in HER2-positive/hormone receptor-positive breast cancer treated with neoadjuvant trastuzumab and pertuzumab: A correlative analysis from the PerELISA trial
Creators: name: Perou, C.M
name: Conte, P
name: Blasco, P
name: Castillo, O
name: Prat, A
name: Galván, P
name: Paré, L
name: Marín-Aguilera, M
name: Guarneri, V
name: Brasó-Maristany, F
name: Parker, J.S
name: Miglietta, F
name: Giorgi, C.A
name: Bottosso, M
name: Villagrasa, P
name: Dieci, M.V
name: Griguolo, G
name: Vivancos, A
Publisher: name: Elsevier B.V.
Year: 2022

description: Background: HER2DX is a prognostic and predictive assay in early-stage HER2-positive breast cancer based on clinical features and the expression of 4 gene signatures (immune, proliferation, luminal differentiation and HER2 amplicon), including ERBB2 mRNA levels. Here, we evaluated the ability of HER2DX to predict efficacy of a de-escalated, chemotherapy-free neoadjuvant regimen in HER2-positive/hormone receptor-positive breast cancer. Methods: HER2DX was evaluated on pre-treatment tumour samples from the PerELISA phase II study focused on postmenopausal patients with operable HER2-positive/hormone receptor-positive breast cancer. Patients received 2-weeks of letrozole, and then underwent a re-biopsy for Ki67 evaluation. Patients with endocrine therapy sensitive disease (ESD) (i.e., >20.0% Ki67 relative reduction at week 2) continued letrozole and 5 cycles of trastuzumab and pertuzumab. Primary aim was to test the ability of HER2DX risk-score, HER2DX pCR score and HER2DX ERBB2 mRNA score (as continuous variables and group categories) to predict pathological complete response (pCR) in patients with ESD. Logistic regression and receiver–operator curve (ROC) analysis assessed associations of HER2DX scores with pCR and ESD. Findings: HER2DX was evaluated in 55 patients (86.0%) enrolled in PerELISA and 40 patients (73.0%) had ESD. The pCR rate in patients with ESD was 22.5% (9/40). In this group, HER2DX pCR score and HER2DX ERBB2 mRNA score were significantly associated with pCR (p = 0.008 and p = 0.003, univariate logistic regression model; area under ROC [AUC] = 0.803 and 0.896). The pCR rate in low, medium, and high HER2DX pCR score groups was 7.7% (2/26), 46.2% (6/13) and 100.0% (1/1), respectively. The pCR rate in low, medium, and high HER2DX ERBB2 score groups was 0.0% (0/12), 7.7% (1/13) and 53.3% (8/15), respectively. HER2DX pCR score was also significantly associated with Ki-67 response following 2-weeks of letrozole (p = 0.002, univariate logistic regression model; AUC = 0.775). The rate of ESD in low, medium, and high HER2DX pCR score groups was 89.7% (26/29), 65.0% (13/20) and 16.7% (1/6), respectively. Interpretation: HER2DX predicts response following neoadjuvant letrozole in combination with dual HER2 blockade with trastuzumab and pertuzumab in early-stage HER2-positive/hormone receptor-positive breast cancer. Funding: This study received funding from Reveal Genomics.
Large Scale Structure and Supersymmetric Inflation without Fine Tuning
Creators: name: Dvali, G.
name: Shafi, Q.
name: Schaefer, R.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We explore constraints on the spectral index $n$ of density fluctuations and the neutrino energy density fraction $Ω_{HDM}$, employing data from a variety of large scale observations. The best fits occur for $n\approx 1$ and $Ω_{HDM} \approx 0.15 - 0.30$, over a range of Hubble constants $40-60$ km s$^{-1}$ Mpc$^{-1}$. We present a new class of inflationary models based on realistic supersymmetric grand unified theories which do not have the usual `fine tuning' problems. The amplitude of primordial density fluctuations, in particular, is found to be proportional to $(M_X /M_P)^2$, where $M_X (M_P)$ denote the GUT (Planck) scale, which is reminiscent of cosmic strings! The spectral index $n = 0.98$, in excellent agreement with the observations provided the dark matter is a mixture of `cold' and `hot' components.
description: LaTEX, 14 pp. + 1 postscript figure appended
The lamppost model: effects of photon trapping, the bottom lamp and disc truncation
Creators: name: Niedzwiecki, Andrzej
name: Zdziarski, Andrzej A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the lamppost model, in which the primary X-ray sources in accreting black-hole systems are located symmetrically on the rotation axis on both sides of the black hole surrounded by an accretion disc. We show the importance of the emission of the source on the opposite side to the observer. Due to gravitational light bending, its emission can increase the direct (i.e., not re-emitted by the disc) flux by as much as an order of magnitude. This happens for near to face-on observers when the disc is even moderately truncated. For truncated discs, we also consider effects of emission of the top source gravitationally bent around the black hole. We also present results for the attenuation of the observed radiation with respect to that emitted by the lamppost as functions of the lamppost height, black-hole spin and the degree of disc truncation. This attenuation, which is due to the time dilation, gravitational redshift and the loss of photons crossing the black-hole horizon, can be as severe as by several orders of magnitude for low lamppost heights. We also consider the contribution to the observed flux due to re-emission by optically-thick matter within the innermost stable circular orbit.
description: submitted to MNRAS
Meson Synchrotron Emission from Central Engines of Gamma-Ray Bursts with Strong Magnetic Fields
Creators: name: Tokuhisa, Akira
name: Kajino, Toshitaka
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Gamma-ray bursts (GRBs) are presumed to be powered by still unknown central engines for the timescales in the range $1ms \sim$ a few s. We propose that the GRB central engines would be a viable site for strong meson synchrotron emission if they were the compact astrophysical objects such as neutron stars or rotating black holes with extremely strong magnetic fields $H \sim10^{12} - 10^{17}G$ and if protons or heavy nuclei were accelerated to ultra-relativistic energies of order $\sim 10^{12}-10^{22}eV$. We show that the charged scalar mesons like $π^{\pm}$ and heavy vector mesons like $ρ$, which have several decay modes onto $π^{\pm}$, could be emitted with high intensity a thousand times larger than photons through strong couplings to ultra-relativistic nucleons. These meson synchrotron emission processes eventually produce a burst of very high-energy cosmic neutrinos with $10^{12} eV \leq E_ν$. These neutrinos are to be detected during the early time duration of short GRBs.
description: 12 pages, 4 figures. Accepted for publication in the Astrophysical Journal Letters
$D^*$ Radiative Decays and Strong Coupling of Heavy Mesons with Soft Pions in a QCD Relativistic Potential Model
Creators: name: Colangelo, P.
name: De Fazio, F.
name: Nardulli, G.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the framework of a QCD inspired relativistic potential model, we evaluate radiative decay rates of heavy mesons and their coupling with soft pions. The agreement with the existing experimental data is satisfactory. In the limit $m_Q \to \infty$ one obtains results in agreement with the Heavy Quark Effective Theory and is able to predict the values of the relevant couplings; in particular, for the scaled $B^*B π$ strong coupling constant $g$, we find that the non relativistic constituent quark model prediction $g=1$ is modified, by the inclusion of the relativistic effects due to the light quarks, to the value $g=1/3$, in agreement with recent QCD sum rules determination.
description: LaTex, 11 pages, BARI-TH/94-180
Madrepora flexuosa Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Oculinidae
Madrepora
Madrepora flexuosa

description: Madrepora flexuosa [spec. nov.]
M. composita, stellis cylindricis flexuosis scabris: superne distinctis fastigiatis.
Amoen. acad. 1. p. 96. t. 4. f. XIII: 5. Madrepora composita, cylindris flexuosis scabris, cortice hinc inde coalitis.
Habitat .. fossilis.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 796, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Heterojunction structures for reduced noise in large-area and sensitive perovskite x-ray detectors
Creators: name: Ni Z
name: Huang J
name: Xiao X
name: Xu S
name: Zhao L
name: Zhou Y
name: Zhao J
Publisher: name: American Association for the Advancement of Science
Year: 2021

description: Polycrystalline perovskites can be readily fabricated into large areas using solution depositions; however, they suffer from large dark currents that are tens to hundreds times higher than industrially relevant values, limiting their application in low-dose x-ray detection. Here, we show that the application of a heterojunction structure into polycrystalline films significantly reduces the dark current density by more than 200 times to subnanoampere per square centimeter without reducing the sensitivity of the detectors. The heterojunction perovskite films are formed by laminating several membrane films filled with perovskites of different bandgaps. A gradient bandgap is formed during annealing. The detectors have a lowest detectable dose rate of 13.8 ± 0.29 nGyair s-1 for 40-keV x-ray and can conduct dynamic x-ray imaging at a low-dose rate of 32.2 nGyair s-1. Simulation and experimental analysis show that the heterojunction is tolerant of halide diffusion and can be stable for over 15 years.
Additional file 2 of SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism
Creators: name: Zhang, Yue
name: Li, Ting
name: Pan, Miaoxia
name: Wang, Wei
name: Huang, Wenhui
name: Yuan, Yafei
name: Xie, Zhanzhan
name: Chen, Yixin
name: Peng, Jun
name: Li, Xu
name: Meng, Ying
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 2 MTT test for compounds used to treat cells. Cells were treated as indicated and their concentrations were showed in Materials and Methods section. Then, MTT tests were performed following manufacture’s instruction (Beyond, Shanghai, China). CSE cigarette smoke extract, MitoQ mitoquinone, Feno fenofibrate, OA oleic acid, ETO etomoxir, BA bafilomycin.
Period-Luminosity-Colour distribution and classification of Galactic oxygen-rich LPVs
Creators: name: Barthes, D.
name: Luri, X.
name: Alvarez, R.
name: Mennessier, M. O.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The absolute K magnitudes and kinematic parameters of about 350 oxygen-rich Long-Period Variable stars are calibrated, by means of an up-to-date maximum-likelihood method, using Hipparcos parallaxes and proper motions together with radial velocities and, as additional data, periods and V-K colour indices. Four groups, differing by their kinematics and mean magnitudes, are found. For each of them, we also obtain the distributions of magnitude, period and de-reddened colour of the base population, as well as de-biased period-luminosity-colour relations and their two-dimensional projections. The SRa semiregulars do not seem to constitute a separate class of LPVs. The SRb appear to belong to two populations of different ages. In a PL diagram, they constitute two evolutionary sequences towards the Mira stage. The Miras of the disk appear to pulsate on a lower-order mode. The slopes of their de-biased PL and PC relations are found to be very different from the ones of the Oxygen Miras of the LMC. This suggests that a significant number of so-called Miras of the LMC are misclassified. This also suggests that the Miras of the LMC do not constitute a homogeneous group, but include a significant proportion of metal-deficient stars, suggesting a relatively smooth star formation history. As a consequence, one may not trivially transpose the LMC period-luminosity relation from one galaxy to the other.
description: 13 pages, 23 figures. Accepted for publication in A&AS
High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy
Creators: name: Zhai, Y
name: He, Z
name: Zhang, H
name: Sun, J
name: Sun, B
name: Jiang, Q
name: Xu, Y
name: Jing, Y
name: Ye, H
name: Lv, Q
name: Luo, C
name: Huang, L
name: Wang, M
Publisher: name: American Chemical Society
Year: 2019

description: Photodynamic therapy (PDT) shows a promising synergy with chemotherapy in the therapeutic outcome of malignant cancers. The minimal invasiveness and nonsystemic toxicity are appealing advantages of PDT, but combination with chemotherapy brings in the nonselective toxicity. We designed a polymeric nanoparticle system that contains both a chemotherapeutic agent and a photosensitizer to seek improvement for chemo-photodynamic therapy. First, to address the challenge of efficient co-delivery, polymer-conjugated doxorubicin (PEG-PBC-TKDOX) was synthesized to load photosensitizer chlorin e6 (Ce6). Ce6 is retained with DOX by a ?-πstacking interaction, with high loading (41.9 wt %) and the optimal nanoparticle size (50 nm). Second, light given in PDT treatment not only excites Ce6 to produce cytotoxic reactive oxygen species (ROS) but also spatiotemporally activates a cascade reaction to release the loaded drugs. Finally, we report a self-destructive polymeric carrier (PEG-PBC-TKDOX) that depolymerizes its backbone to facilitate drug release upon ROS stimulus. This is achieved by grafting the ROS-sensitive pendant thioketal to aliphatic polycarbonate. When DOX is covalently modified to this polymer via thioketal, target specificity is controlled by light, and off-target delivery toxicity is mostly avoided. An oral squamous cell carcinoma that is clinically relevant to PDT was used as the cancer model. We put forward a polymeric system with improved efficiency for chemo-photodynamic therapy and reduced off-target toxicity.
Production of Pairs of Sleptoquarks in Hadron Colliders
Creators: name: de Montigny, M.
name: Marleau, L.
name: Simon, G.
Publisher: name: arXiv
Year: 1994
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the cross section for the production of pairs of scalar leptoquarks (sleptoquarks) in a supersymmetric $E_6$ model, at hadron colliders. We estimate higher order corrections by including $π^2$ terms induced by soft-gluon corrections. Discovery bounds on the sleptoquark mass are estimated at collider energies of 1.8, 2, and 4 TeV (Tevatron), and 16 TeV (LHC).
description: 8 pages, REVTEX, (1 fig. available on request), LAVAL-PHY-94-13/McGILL-94-26/SPhT-94-072
High grain boundary recombination velocity in polycrystalline metal halide perovskites
Creators: name: Ni Z
name: Fei C
name: Huang J
name: Xu S
name: Gu H
name: Jiao H
Publisher: name: American Association for the Advancement of Science
Year: 2022

description: Understanding carrier recombination processes in metal halide perovskites is fundamentally important to further improving the efficiency of perovskite solar cells, yet the accurate recombination velocity at grain boundaries (GBs) has not been determined. Here, we report the determination of carrier recombination velocities at GBs (SGB) of polycrystalline perovskites by mapping the transient photoluminescence pattern change induced by the nonradiative recombination of carriers at GBs. Charge recombination at GBs is revealed to be even stronger than at surfaces of unpassivated films, with average SGB reaching 2200 to 3300 cm/s. Regular surface treatments do not passivate GBs because of the absence of contact at GBs. We find a surface treatment using tributyl(methyl)phosphonium dimethyl phosphate that can penetrate into GBs by partially dissolving GBs and converting it into one-dimensional perovskites. It reduces the average SGB by four times, with the lowest SGB of 410 cm/s, which is comparable to surface recombination velocities after passivation.
Microscopic Description of Thermodynamics of Lipid Membrane at Liquid-Gel Phase Transition
Creators: name: Kheyfets, Boris
name: Galimzyanov, Timur
name: Mukhin, Sergei
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A microscopic model of the lipid membrane is constructed that provides analytically tractable description of the physical mechanism of the first order liquid-gel phase transition. We demonstrate that liquid-gel phase transition is cooperative effect of the three major interactions: inter-lipid van der Waals attraction, steric repulsion and hydrophobic tension. The model explicitly shows that temperature-dependent inter-lipid steric repulsion switches the system from liquid to gel phase when the temperature decreases. The switching manifests itself in the increase of lateral compressibility of the lipids as the temperature decreases, making phase with smaller area more preferable below the transition temperature. The model gives qualitatively correct picture of abrupt change at transition temperature of the area per lipid, membrane thickness and volume per hydrocarbon group in the lipid chains. The calculated dependence of phase transition temperature on lipid chain length is in quantitative agreement with experimental data. Steric repulsion between the lipid molecules is shown to be the only driver of the phase transition, as van der Waals attraction and hydrophobic tension are weakly temperature dependent.
Additional file 3: of Comparative root transcriptome of wild Arachis reveals NBS-LRR genes related to nematode resistance
Creators: name: Mota, Ana
name: Vidigal, Bruna
name: Danchin, Etienne
name: Togawa, Roberto
name: Leal-Bertioli, Soraya
name: Bertioli, David
name: Araujo, Ana
name: Brasileiro, Ana
name: Guimaraes, Patricia
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S1. Expression profiles of 14 nematode responsive candidate genes in A. stenosperma and A. duranensis at 3,6 and 9 DAI with M. arenaria. (PDF 46 kb)
New polyketides from the basidiomycetous fungus Pholiota sp.
Creators: name: Lin, Jie
name: Huo, Rui-Yun
name: Hou, Lin
name: Jiang, Shan
name: Wang, Shu-Lin
name: Deng, Yan-Ling
name: Liu, Ling
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Two new polyketides, pholiotones B and C (1 and 2), and four known compounds, trichodermatide D (3), vermistatin (4), dehydroaltenuene A (5) and terpestacin (6) were isolated from the crude extract of Pholiota sp. Their structures were identified by NMR and MS spectroscopic data. The absolute configurations of compounds 1 and 2 were elucidated by modified Mosher’s method, electronic circular dichroism (ECD) calculations and 13C NMR calculations as well as DP4+ probability analyses. All the compounds were evaluated for their antifungal and cytotoxicity.
Plumes in stellar convection zones
Creators: name: Zahn, Jean-Paul
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: All numerical simulations of compressible convection reveal the presence of strong downwards directed flows. Thanks to helioseismology, such plumes have now been detected also at the top of the solar convection zone, on super- granular scales. Their properties may be crudely described by adopting Taylor's turbulent entrainment hypothesis, whose validity is well established under various conditions. Using this model, one finds that the strong density stratification does not prevent the plumes from traversing the whole convection zone, and that they carry upwards a net energy flux (Rieutord & Zahn 1995). They penetrate to some extent in the adjacent stable region, where they establish a nearly adiabatic stratification. These plumes have a strong impact on the dynamics of stellar convection zones, and they play probably a key role in the dynamo mechanism.
description: Proceedings of the 14th Florida Workshop in Nonlinear Astronomy and Physics, "Astrophysical Turbulence and Convection", Eds. J.R. Buchler and H. Kandrup, to appear in the Annals of the New York Academy of Sciences (15 pages, 3 figures)
Physical renormalization condition for de Sitter QED
Creators: name: Hayashinaka, Takahiro
name: Xue, She-Sheng
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We considered a new renormalization condition for the vacuum expectation values of the scalar and spinor currents induced by a homogeneous and constant electric field background in de Sitter spacetime. Following a semiclassical argument, the condition named maximal subtraction imposes the exponential suppression on the massive charged particle limit of the renormalized currents. The maximal subtraction changes the behaviors of the induced currents previously obtained by the conventional minimal subtraction scheme. The maximal subtraction is favored for a couple of physically decent predictions including the identical asymptotic behavior of the scalar and spinor currents, the removal of the infrared (IR) hyperconductivity from the scalar current, and the finite current for the massless fermion.
description: 6 pages, 4 figures
Madrepora turbinata Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Scleractinia
Oculinidae
Madrepora
Madrepora turbinata

description: Madrepora turbinata [spec. nov.]
M. composita, stellis turbinatis laevibus subdichotomis apice contingentibus.
Edw. av. t. 194.
Habitat ..
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 796, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206