cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Visible learning: Educational innovation for shaping 21st century thai teachers
Creators: name: Mahapoonyanont, Natcha
name: Phinla, Wipapan
name: Phinla, Wipada
name: Mahapoonyanont, Tharadeth
name: Jeerarat, Khanitta
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 390102
subject: Curriculum and pedagogy theory and development

description: This study examines how model schools in the "Thai Teachers for Students in the 21st Century" initiative use John Hattie's Visible Learning framework. Visible learning emphasizes evidence-based teacher methods that improve learning outcomes through transparency and quantifiable progress. The research emphasizes the fundamental components of visible learning, such as effective feedback, explicit instruction, student self-evaluation, and well-defined learning objectives. Thai educational institutions have integrated these components through teacher professional development, action research, and Professional Learning Communities. The study's three main objectives are to (1) learn from model schools that use visible learning, (2) design a training program to improve Thai teachers' educational management, and (3) create 21st-century model schools that use student-centered learning. The investigation examined how visible learning enhanced student engagement, analytical thinking, and educational equity, with a specific focus on its impact on teaching and learning in the five southern border provinces of Thailand. The findings indicate that visible learning improves academic performance, promotes teacher collaboration, and reduces educational inequalities. The teacher training program demonstrated impressive participant satisfaction, accompanied by notable enhancements in knowledge and teaching methodologies. The study concludes with suggestions for the Ministry of Education, school leaders, and policymakers to more extensively incorporate visible learning into the Thai education system to equip students for the challenges of the 21st century.
Additional file 7 of Prioritising attributes for tuberculosis preventive treatment regimens: a modelling analysis
Creators: name: Vesga, Juan F.
name: Lienhardt, Christian
name: Nsengiyumva, Placide
name: Campbell, Jonathon R.
name: Oxlade, Olivia
name: den Boon, Saskia
name: Falzon, Dennis
name: Schwartzman, Kevin
name: Churchyard, Gavin
name: Arinaminpathy, Nimalan
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 7. Further sensitivity analysis: Tables S7-S8 and Fig. S12. Results with 6H scale-up as alternative comparator. Fig. S13. Alternative optimisation order of regimen properties. Table S9 and Fig. S14. Sensitivity analysis on forgiveness thresholds. Table S10. Sensitivity analysis on efficacy of regimen on Rif resistant TB. Fig. S15 and Table S11. Widened ranges for regimen properties. Fig. S16. PRCCs assuming lower ease of adherence. Fig. S17. Effect of regimen duration on epidemiological impact. Fig. S18. PRCCs for a Rifampicin-sparing regimen.
Equity and Digital Literacies : Issues of Access, Ethics and Engagement in a Youth Community Setting
Creators: name: Ford, Colin Andrew
Publisher: name: The University of British Columbia
Year: 2019

description: This article reports on the issue of confidentiality faced by a community youth agency that provides access to digital technology for homeless or street-involved youth. Social media is the prevalent form of communication in displaced communities and presents certain ethical challenges as a result of creating and sharing media with potential unintended audiences. Ensuring ethical practices is a key aspect of the ongoing process of developing digital literacy that changes as technology evolves. It requires the facilitator’s focused attention to guide the youth in their ability to consider their digital footprint and potential unintended consequences of their practices.
Snail_RNA_Protein_Sequences
Creators: name: Cerullo, Antonio R.
name: B. McDermott, Maxwell
name: Pepi, Lauren E.
name: Lui, Zhi-Lun
name: Barry, Diariou
name: Zhang, Sheng
name: Yang, Xu
name: Azadi, Parastoo
name: Holford, Mande
name: Braunschweig, Adam B.
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310204
subject: Genomics and transcriptomics
classificationCode: 310107
subject: Glycobiology
classificationCode: 310109
subject: Proteomics and intermolecular interactions (excl. medical proteomics)

description: This data includes RNA sequences from Cornu aspersum (garden snail) and the entire set of assembled RNA sequences (and their amino acid translations with stop codons removed) as well as the annotated shortlist of the proteins cross-validated with proteomics.
Additional file 1 of Hyolithid-like hyoliths without helens from the early Cambrian of South China, and their implications for the evolution of hyoliths
Creators: name: Liu, Fan
name: Skovsted, Christian B.
name: Topper, Timothy P.
name: Zhang, Zhifei
Publisher: name: figshare
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Additional file 1. List of selected characters and coding comments on hyoliths in cladistic analysis. Figure S1. The trees generated from TNT v. 1.5.
HOW PUBLIC EXPENDITURE TRACKING SYSTEMS ARE IMPROVING BUDGET IMPLEMENTATION AND ACCOUNTABILITY IN DEVELOPING COUNTRIES
Creators: name: Mbonigaba Celestin
Publisher: name: Zenodo
Year: 2016

description: Public Expenditure Tracking Systems (PETS) play a crucial role in enhancing budget transparency and accountability in developing countries, where inefficient public spending and corruption lead to significant economic losses. This study examines the effectiveness of PETS in improving budget implementation from 2011 to 2015, focusing on their role in reducing financial mismanagement and ensuring that allocated funds reach their intended beneficiaries. The research employed a secondary data analysis approach, utilizing reports from global institutions such as the World Bank, IMF, and OECD. Statistical analysis revealed significant findings: the chi-square test confirmed discrepancies between budget allocation and utilization (χ² = 6.24, p = 0.044), regression analysis demonstrated a strong positive correlation between institutional capacity and PETS efficiency (r = 1.0, p < 0.001), and a t-test confirmed that digital tracking reduced misallocation rates by up to 57% in Kenya, 50% in Uganda, and 44% in Rwanda. These findings highlight the importance of PETS in enhancing fiscal responsibility, but also emphasize the need for stronger institutional frameworks, increased public participation, and further technological integration to maximize efficiency. The study recommends policy reforms to strengthen governance, expand digital tracking adoption, and encourage citizen engagement in budget monitoring. Future research should explore the role of artificial intelligence in automating PETS for enhanced transparency.
Conceptualising Addiction as Disability in Discrimination Law : A Situated Comparison
Creators: name: Bunn, Rebecca
Publisher: name: The University of British Columbia
Year: 2019

description: People labelled as having an addiction and people with disabilities face significant discrimination in their daily lives. In countries where targeted disability discrimination law is applied, it is often assumed that including addiction in the definition of disability will protect those labelled as having an addiction from discrimination. Several scholars have considered the effects of excluding addiction from the remit of discrimination law, but there has been less work examining the consequences – both positive and negative – of including addiction. Using the method of ‘situated comparisons’ developed by intersectionality scholars, this article interrogates how addiction and disability are co-constituted in two contrasting legal and geographical contexts, where people labelled as having an addiction have sought to assert their right to equality before the law. By comparing the application of targeted discrimination law in Australia with a human rights charter in Canada, it demonstrates how systems of power such as ableism and neoliberalism work through the law to co-constitute addiction and disability in ways that are stigmatising, even within legal approaches that aim to eliminate discrimination. Furthermore, the law, in both contexts, fails to recognise the intersectional nature of discrimination often experienced by these groups. The article contends that conceptualising addiction as a disability will not necessarily reduce the discrimination faced by people labelled as having an addiction; and concludes with recommendations for both policy and legal practice.
Supplementary document for Spatio-Spectral Quantum State Estimation of Photon Pairs from Optical Fiber Using Stimulated Emission - 7424239.pdf
Creators: name: Kim, Dong Beom
name: Hu, Xiye
name: U'Ren, Alfred
name: Garay-Palmett, Karina
name: Lorenz, Virginia
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Nonlinear Optics and Spectroscopy
Quantum Information, Computation and Communication
Quantum Optics

description: Supplement 1 tex file
РАЗВИТИЕ ТВОРЧЕСКОГО МЫШЛЕНИЯ СТУДЕНТОВ ПРИ ИЗУЧЕНИИ ИСТОРИЧЕСКИХ ДИСЦИПЛИН
Creators: name: Пулатова, Зарина
Publisher: name: Zenodo
Year: 2025

description: В статье рассматривается проблема развития креативного (творческого) мышления у студентов в процессе изучения исторических дисциплин. Анализируются традиционные формы преподавания (лекции и семинарские занятия), подчеркивается их важная роль в формировании системного представления об истории и фактологической основы. В то же время указывается на ограниченность репродуктивных методов, которые могут приводить к пассивному восприятию материала и снижению мотивации. Предлагается расширить лекционно-семинарскую парадигму за счёт интерактивных и инновационных методов, стимулирующих творческую переработку исторической информации: проблемные вопросы, кейсы, дискуссии. Автор подчеркивает необходимость синтеза классических и современных дидактических подходов, чтобы сформировать у студентов не только базовые исторические знания, но и умения креативно мыслить, ставить вопросы и находить собственные интерпретации исторических фактов и событий.
Additional file 1 of Release of lead from Renaissance lead-glazed ceramics from southern Denmark and northern Germany: implications from acetic acid etching experiments
Creators: name: Rasmussen, Kaare Lund
name: Milner, George R.
name: Delbey, Thomas
name: Jensen, Lisa Kathrine Ivalu
name: Witte, Frauke
name: Rehren, Thilo
name: Kjaer, Ulla
name: Grinder-Hansen, Poul
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 1. Photos of examples of samples analysed in the present work. Analyses of Corning glass standards for SEM-EDS. Full ternary phase diagram.
Additional file 1 of Substitution impacts of Nordic wood-based multi-story building types: influence of the decarbonization of the energy sector and increased recycling of construction materials
Creators: name: Myllyviita, Tanja
name: Hurmekoski, Elias
name: Kunttu, Janni
Publisher: name: figshare
Year: 2022
Subjects: subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. Materials required (as tonnes) of major materials in the finished building alternatives from Tettey et al. [30]. Table S2. Materials required (kg/building) for alternative buildings obtained from Vares et al. (2017). Table S3. Materials required for alternative buildings (kg) per heated floor area obtained from Peñaloza et al. (2018). Table S4. Carbon footprints of wooden construction materials (kg CO2 eq./kg). Table S5. Carbon footprints of plastic construction materials (kg CO2 eq./kg). Table S6. Carbon footprints of other construction materials (kg CO2eq/kg). Table S7. Share of GHG energy emissions caused of the total carbon footprint of a construction material (Ecoinvent 3.0). Table S8. Assumptions behind recycling scenarios.
NCBI curated Pseudo-nitzschia spp. ITS1 Reference Database
Creators: name: Setta, Samantha P.
name: Roche, Katherine
name: Sterling, Alexa R.
Publisher: name: Zenodo
Year: 2025
Subjects: metabarcoding
environmental DNA
ITS1
Pesudo-nitzschia spp.

description: Curated database of Pseudo-nitzschia spp. ITS1 sequences on NCBI as of August 14, 2024.

Primer Name:  ITS1 SterlingGene:   ITS1Length of Target:  235–370

Forward Sequence (5'-3'):   TCCGTAGGTGAACCTGCGG

Reverse Sequence (5'-3'):    CATCCACCGCTGAAAGTTGTAA

Sterling et al. (2022). Emerging harmful algal blooms caused by distinct seasonal assemblages of a toxic diatom. Limnology and Oceanography, 67(11), 2341–2359. https://doi.org/10.1002/lno.12189

White, T., T. Bruns, S. Lee, and J. Taylor. (1990). Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics, p. 315–322. In PCR Protocols: A guide to methods and applications. Academic Press, Inc.

Detailed information on creating and curating the database is outlined in the README.md file. All Pseudo-nitzschia spp. internal transcribed spacer (ITS) sequences from NCBI were downloaded. The sequences are then curated by removing all sequences that do not include the ITS1 region, aligning all sequences, removing sequences that are likely mis-identified (based on alignment and publication), using Sterling et al. (2022) and White et al. (2020) primers to extract ITS1 region, and removing sequences with ambiguous bases (R,Y,S,W,K,M,B,D,H,V,N).
Research to develop a model school for learning management for students in the 21st century based on the concept of visible learning to raise the quality of educational management in educational institutions under the songkhla primary educational service area office 1
Creators: name: Mahapoonyanont, Natcha
name: Phinla, Wipapan
name: Phinla, Wipada
name: Mahapoonyanont, Tharadet
name: Jirarat, Khanitta
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 390102
subject: Curriculum and pedagogy theory and development

description: The goal of this research paper is to create model schools for managing learning in the 21st century by combining the Visible Learning method with Professional Learning Communities (PLC) of teachers in the Songkhla Primary Educational Service Area 1. The goal is to enhance the quality of education by preparing students for a rapidly changing, technology-driven society through the development of essential skills such as critical thinking, creativity, collaboration, and communication. In Thailand, educational reform is necessary to equip students with 21st-century skills. This study integrated John Hattie’s Visible Learning model, emphasizing clear and measurable learning processes, with PLC to support teacher development and enhance student engagement. This study had five steps: looking at the needs and starting points of the case study schools; creating a framework and research tools with the help of experts; checking to see if the framework and tools were useful and workable; creating model schools by setting up PLCs and encouraging learning activities that focus on 21st-century skills; and finally, reviewing and judging the results. The findings revealed that developing model schools for 21st-century learning management using the Visible Learning approach combined with PLC significantly improved both the teaching quality of teachers and the learning outcomes of students. The study showed that students learned 21st-century skills like analytical thinking, teamwork, and problem-solving, and they also did better in school, with O-NET scores in Science and English going up by 12.15 and 21.23%, respectively. School administrators identified student engagement, community support, and effective resource management as key factors in the success of educational transformation. This model demonstrates the potential for sustainable improvement in education quality across diverse contexts.
Additional file 3 of Forecasting daily emergency department arrivals using high-dimensional multivariate data: a feature selection approach
Creators: name: Tuominen, Jalmari
name: Lomio, Francesco
name: Oksala, Niku
name: Palomäki, Ari
name: Peltonen, Jaakko
name: Huttunen, Heikki
name: Roine, Antti
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 3.Residual analysis. The document contains detailed residual analysis of the models performance. (DOCX 4.9 Mb).
Project Inclusion : Confronting Anti-Homeless & Anti-Substance User Stigma in British Columbia
Creators: name: Bennett, Darcie
name: Larkin, D. J.
Publisher: name: The University of British Columbia
Year: 2019

description: By centring and amplifying the voices and experiences of people most affected by BC’s homelessness crisis and drug policy crisis, Project Inclusion identiﬁes the legal, policy-related, and other structural barriers that must be addressed in order to meaningfully prevent opioid-related deaths and other health and safety harms, particularly among people who are experiencing homelessness and people in deep poverty who use substances. Project Inclusion is the culmination of over a year of research by Pivot Legal Society lawyers and researchers, who travelled to ten communities across BC’s ﬁve regional health authorities. Working from the perspective that people are experts in their own lives and hold powerful visions for change, the Pivot team interviewed people about their experiences of homelessness, with accessing harm reduction and health care services, with the criminal justice system, and with accessing services such as income assistance, shelters, and hospitals. For many people who participated in Project Inclusion, the interviews marked a new experience. No matter where Pivot researchers travelled, people shared, again and again, that they had seldom been asked about their lives in a way that suggested to them that their experiences and their visions for change held value. Many individuals shared that they had instead been shown, over the course of their lives and through ongoing interactions with police, other residents of their communities, and even some health care workers, that their homelessness and their substance use deﬁned them and resulted in them being treated as unworthy of respect and dignity. These two markers seemed to be used by others to justify their daily experiences of violence, racism, theft, threats, and ostracism. Project Inclusion study participants described a diversity of life experiences with researchers, yet the commonality of experiences that transcended geography and demographics was striking. In every community that researchers visited, stigma was the unifying thread that shaped people’s lives. Stigma disqualiﬁes people and groups from social acceptance and social equity. Stigma is powerful because it is not always easy to quantify. By shedding light on the experiences and voices of people who are told that they don’t matter because their lives and identities are stigmatized, Project Inclusion makes stigma visible. The project aims to address stigma’s root causes by offering analysis of how laws and policies in BC are both shaped by stigma and serve to perpetuate it. This report offers that analysis alongside actionable recommendations for change.
Additional file 1 of Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study
Creators: name: Jeong, Sung Hoon
name: Hoon Kim, Seung
name: Lee, Doo Woong
name: Park, Eun-Cheol
name: Jang, Suk-Yong
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Table 1. Results of the associationbetween Parkinson's disease and the risk of suicide.
The New Enlightenment:  Beyond the Age of Science towards a magical world view  in the face of Artificial Intelligence.
Creators: name: Galwas, P.A.
Publisher: name: Zenodo
Year: 2024

description: In this paper we argue that we are entering a new age - the New Enlightenment - in which the pervasion of artificial intelligence (AI) and human individuals’ direct interactions with AI, will take us full circle from the peak of scientific dominance to magical world views.

We identify five principal characteristics of the New Enlightenment:

Mirror identities: my identity (i), paired with its virtual spirit (i’);

Identity separation: in the AI ‘digital twin’ and through its reflexive interactions through i’;

Emergent epistemological gaps: combining AI classification and generation capabilities operating in the space of individual interactions with AI digital twins;

Ω-communities: arising from the combination of the above three properties in complex adaptive systems (CASs) yielding genuine surprises; and

Emergent correlation: beyond logic and scientific method.

We conclude by suggesting that we are entering a new age - the New Renaissance.
But We Do DevOps!
Creators: name: Westlake, William
Publisher: name: Zenodo
Year: 2025

description: Everyone wants to say they "do DevOps" — it's become a badge of honor. The term has gone from a cultural shift to a checkbox on a capability matrix. But putting Jenkins in your stack and wiring up a few GitHub actions doesn't mean you're delivering software well. More often than not, teams adopt tools without addressing the bottlenecks those tools were meant to alleviate.
Additional file 1 of An evaluation of an Extension for Community Healthcare Outcomes (ECHO) intervention in cancer prevention and survivorship care
Creators: name: Milgrom, Zheng Z.
name: Severance, Tyler S.
name: Scanlon, Caitlin M.
name: Carson, Anyé T.
name: Janota, Andrea D.
name: Vik, Terry A.
name: Duwve, Joan M.
name: Dixon, Brian E.
name: Mendonca, Eneida A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Survey questions.
Additional file 2 of An evaluation of an Extension for Community Healthcare Outcomes (ECHO) intervention in cancer prevention and survivorship care
Creators: name: Milgrom, Zheng Z.
name: Severance, Tyler S.
name: Scanlon, Caitlin M.
name: Carson, Anyé T.
name: Janota, Andrea D.
name: Vik, Terry A.
name: Duwve, Joan M.
name: Dixon, Brian E.
name: Mendonca, Eneida A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Survey results on self-reported burnout change.
Guide to Coral Reef Restoration: Optimizing efficiency and scale for in situ nurseries and outplanting
Creators: name: Goergen, Elizabeth A.
name: Lustic, Caitlin
name: Levy, Jessica
name: Johnson, Meaghan E.
name: Griffin, Sean
name: Moulding, Alison L.
name: Ross, Andrew
Publisher: name: Coral Restoration Consortium
Year: 2025

description: This Guide is designed to walk practitioners through the process of developing a restoration program and provide foresight for program success. This Guide was developed to fulfill the priorities of the Coral Restoration Consortium's Field-based Propagation Working Group and includes methods, techniques, and guidance for in situ nursery development and outplanting. While not exhaustive, the use of this Guide is a critical step in advancing coral reef restoration by synthesizing knowledge from across the field.
Polyclads from the Gulf of Mexico
Creators: name: Hernández, Alejandro
name: Simoes, Nuno
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Polyclads
subject: GBIF: 108
subject: Biodiversity
subject: Marine biodiversity
subject: Marine Biology
subject: Marine biology
subject: Marine organism
subject: Marine fauna
subject: Aquatic organism

description: This poster is a product of BDMY (www.bdmy.org.mx) project, which was produced in collaboration with the Universidad Nacional Autónoma de México and Kalanbio A.C (www.kalanbio.org)

Designed and illustrated by: naturae.art@gmail.com
Additional file 1 of Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples
Creators: name: Avian, Alice
name: Clemente, Nicolò
name: Mauro, Elisabetta
name: Isidoro, Erica
name: Di Napoli, Michela
name: Dudine, Sandra
name: Del Fabro, Anna
name: Morini, Stefano
name: Perin, Tiziana
name: Giudici, Fabiola
name: Cammisuli, Tamara
name: Foschi, Nicola
name: Mocenigo, Marco
name: Montrone, Michele
name: Modena, Chiara
name: Polenghi, Martina
name: Puzzi, Luca
name: Tomaic, Vjekoslav
name: Valenti, Giulio
name: Sola, Riccardo
name: Zanolla, Shivani
name: Vogrig, Enea
name: Riva, Elisabetta
name: Angeletti, Silvia
name: Ciccozzi, Massimo
name: Castriciano, Santina
name: Pachetti, Maria
name: Petti, Matteo
name: Centonze, Sandro
name: Gerin, Daniela
name: Banks, Lawrence
name: Marini, Bruna
name: Canzonieri, Vincenzo
name: Sopracordevole, Francesco
name: Zanconati, Fabrizio
name: Ippodrino, Rudy
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Intralaboratory reproducibility of HPV Selfy according to Meijer’s guidelines. HPV Selfy assay was performed twice on a subpopulation of 521 samples of which 157 samples positive to HC2. Overall concordance observed was 94.6% (kappa value of 0.87). Table S2. Interlaboratory reproducibility of HPV Selfy according to Meijer’s guidelines. HPV Selfy assay was performed in another laboratory (MediChrom) on a subpopulation of 500 samples of which 150 samples positive to HC2. Overall concordance observed was 93.6% (kappa value of 0.85). Table S3. Intra-laboratory reproducibility of genotype findings of HPV Selfy. Data are presented as number of each genotype detected in each run (i.e. run1 and/or run 2), and numbers do not count up to the total number of HR-HPV positive samples due to multiple infections.
Rhein potentiates doxorubicin in treating triple negative breast cancer by inhibiting cancer-associated fibroblasts
Creators: name: Xiong, Yang
name: Xu, Shujun
name: Ma, Ninghui
name: Shi, Jingbin
name: Wang, Menglin
name: Zheng, Shuang
name: Zhang, Hongyan
name: Huang, Jingyi
name: Luo, Ninghchao
Publisher: name: Elsevier
Year: 2024

description: Cancer-associated fibroblasts (CAFs), one of the most abundant stromal cells in the tumor microenvironment, mediate desmoplastic responses. CAFs are major drivers for the failure of triple-negative breast cancer (TNBC) chemotherapy. It is well-documented that many traditional Chinese medicines (TCMs) exhibit potent anti-fibrotic effects based on their capacity to suppress the production of ECM proteins. Therefore, the combination of TCMs exhausting CAFs with chemotherapy is a potential regimen for treating TNBC. Here, TGF-β was used to induce the transformation of NIH/3T3 cells into CAFs for screening TCMs to inhibit tumor fibrosis. After screening 11 candidate TCMs for inhibiting CAFs using the TMS method, rhein (Rhe) was found to strongly inhibit the proliferation of CAFs. Therefore, Rhe was chosen as a representative TCM to inhibit CAFs in TNBC. A 4T1Fluc/CAFs tumor sphere resembling the TME in vivo was constructed to explore the feasibility of inhibiting CAFs to sensitize DOX in treating TNBC. It was found that CAFs apparently hindered the penetration of DOX into 4T1Fluc/CAFs tumor spheres and decreased the the sensitivity of 4T1Fluc cells to DOX, while Rhe significantly restored the sensitivity of 4T1Fluc cells to DOX by inhibiting the proliferation of CAFs. Consistent with in vitro results, Rhe reversed the abnormal activation of CAFs and diminished the accumulation of collagen in 4T1Fluc mouse xenograft models. This removal of stromal barrier facilitated the antitumor efficacy of DOX. Altogether, this study demonstrated for the first time that Rhe could inhibit tumor tissue fibrosis and synergize DOX to treat TNBC.
Supplementary document for CoCoCs: Co-optimized Comressive Imaging Driven by High-level Vision - 5981131.pdf
Creators: name: Huang, Honghao
name: Hu, Chengyang
name: Li, Jingwei
name: Dong, Xiaowen
name: Chen, Hongwei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Image Processing

description: Supplement 1
Additional file 1 of Seroprevalence of anti-Toxocara canis antibodies and associated risk factors among dog owners in the rural community of Nakhon Si Thammarat province, southern Thailand
Creators: name: Na-Ek, Prasit
name: Narkkul, Udomsak
name: Phasuk, Nonthapan
name: Punsawad, Chuchard
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1. Questionnaire Form.
Adjunctive hyperbaric oxygen therapy promotes successful healing in patients with refractory Crohn Disease
Creators: name: Feitosa, Marley Ribeiro
name: Parra, Rogério Serafim
name: Tamaki, Camila Mussolin
name: Filho, Omar Féres
name: Rocha, José Joaquim Ribeiro Da
name: Féres, Omar
Publisher: name: F1000Research
Year: 2016

description: The purpose of the study was to investigate the adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn disease. A total of 29 subjects with refractory daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn’s disease. A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn’s disease healing rate was 65%. Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn’s disease.
Des algorithmes aux urnes : repenser les dynamiques électorales sous le prisme de l'IA responsable
Creators: name: Mboa Nkoudou, Thomas Hervé
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Artificial Intelligence
subject: Elections
subject: Democracy
subject: Algorithms

description: Cette présentation a été faite dans le cadre du 92è congrès de l'ACFAS.  

Colloque 309 - Responsabiliser le numérique : enjeux théoriques, méthodologiques et politiques (Colloque CRIHN)
MAKTAB O`QUVCHILARINING CHANOQ SUYAGI ANTROPOMETRIK PARAMETRLARI
Creators: name: Ozodbekova, Sitora
name: Adilov, Abdujabbor
name: Xatamov, A.I.
Publisher: name: Zenodo
Year: 2024

description: Maktab o‘quvchilarida chanoq suyagi antropometrik parametrlarini o‘rganish.
Stimuli-Responsive Hydrogels from Dynamic Network Interactions
Creators: name: Ollier, Rachel C
Publisher: name: University of Notre Dame
Year: 2025
Subjects: classificationCode: 3206
subject: Medical biotechnology
subject: FOS: Medical biotechnology
classificationCode: 401202
subject: Bio-fluids

description: Hydrogels are hydrated 3-dimensional networks of polymer chains. The polymer chains are connected by crosslinks, which may be covalent bonds or physical network junctions based on non-covalent intermolecular interactions. While covalent crosslinks give hydrogels advantageous mechanical properties such as high stiffness and strength, these bonds translate to static networks which are unable to respond to environmental stimuli. In contrast, dynamic or non-covalent crosslinks endow hydrogels with the ability to respond to environmental cues. Stimuli-responsive hydrogels are of interest for a large range of applications, many of which are bioinspired, with the goal of emulating the rapid and complex natural responses of living organisms to their environments. These include sensors based on mechanoresponsive strain-stiffening or mechanochromic hydrogels, shear-thinning and self- healing hydrogels for 3D printing, wound dressings, and injectable therapeutics, and chemoresponsive hydrogels for controlled release and delivery of therapeutics. Here, dynamic and non-covalent crosslinking motifs are utilized to develop hydrogel-based materials which exhibit tunable stimuli-responsive behaviors. First, the strain-responsive stiffening of 4-arm poly(ethylene glycol) hydrogels crosslinked with dynamic-covalent boronate esters is explored. This system allows the impact of dynamic-covalent crosslinking on strain-stiffening to be studied without additional polymer chain interactions. The magnitude of the strain-stiffening response increases with decreasing crosslink density and gel stiffness. A cellulose-based hydrogel system is characterized next, which incorporates both dynamic-covalent and hydrogen bonding motifs. The contributions of these interactions to various mechanoresponsive behaviors, including strain-stiffening and shear-thickening, are studied. To further explore the impact of dynamic interactions on hydrogel strain-stiffening, the behaviors of covalent and dynamic-covalent hydrogels in response to mechanical stimuli are compared. This work reveals that dynamic crosslinking is essential for strain-stiffening in synthetic hydrogel systems, and in fact, the magnitude of the strain-stiffening response is well- correlated with the reverse rate constant of the crosslinking reaction. Lastly, a chemoresponsive hydrogel capsule system is designed based on dynamic-covalent crosslinking and electrostatic interactions. Enzymatic activity enabled glucose-responsive dissolution. This work highlights the importance of dynamic crosslinking motifs in engineering stimuli- responsive hydrogel materials. These findings have provided design insight towards realizing biomimetic materials with tunable stimuli-responsive properties.
Additional file 1 of UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases
Creators: name: Suárez-Rivero, Juan M.
name: Pastor-Maldonado, Carmen J.
name: Povea-Cabello, Suleva
name: Álvarez-Córdoba, Mónica
name: Villalón-García, Irene
name: Talaverón-Rey, Marta
name: Suárez-Carrillo, Alejandra
name: Munuera-Cabeza, Manuel
name: Reche-López, Diana
name: Cilleros-Holgado, Paula
name: Piñero-Perez, Rocío
name: Sánchez-Alcázar, José A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: Additional file 1.Supplementary figures.
Additional file 1 of From formic acid to single-cell protein: genome-scale revealing the metabolic network of Paracoccus communis MA5
Creators: name: Tong, Sheng
name: Zhao, Lizhi
name: Zhu, Daling
name: Chen, Wuxi
name: Chen, Limei
name: Li, Demao
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file1: Table S1. Primers used in this study. Table S2. Concentration detection and integrity analysis of RNA. Table S3. Concentration detection and integrity analysis of DNA. Table S4. Number of genes associated with the 24 general COG functional categories. Table S5. Differentially expressed genes (DEGs) in both the B vs. A group and the C vs. A group. Table S6. Significant KEGG pathway-relevant DEGs in the B vs. A group. Table S7. Significant KEGG pathway-relevant DEGs in the C vs. A group. Fig. S1 Agarose electrophoresis results of genomic DNA (A) and total RNA (B). Genomic DNA was isolated from strain MA5 grown in Group A. A1-A3: total RNA extraction from Group A; B1-B3: total RNA extraction from Group B; C1-C3: total RNA extraction from Group C. Fig. S2 Circular representation of the genome of strain MA5. The genome of strain MA5 consists of 3 contigs, Chr1 (1.41 MB), Chr2 (2.39 MB) and Plas1 (0.67 MB). Fig. S3 Expression of the selected DEGs in the B vs. A group was examined by real-time PCR with dnaN as the reference gene. Error bars represent the standard deviation of three replicates. odc: ornithine decarboxylase; fadH: 3-oxoacyl-[acyl-carrier-protein] synthase; cysI: sulfite reductase; cdp: cell division protein; katG: peroxidase; nir: nitrite reductase. Fig. S4 KEGG pathway enrichment of the downregulated DEGs in the C vs. A group. The size of the circle represents the number of DEGs in the pathway, and the color of the circle represents the padj value (p value adjusted to false discovery rate), reflecting the enrichment degree. Fig. S5 Expression of the selected DEGs in the C vs. A group was examined by real-time PCR with dnaN as the reference gene. Error bars represent the standard deviation of three replicates. agxT: serine transaminase; aspB: aspartate transaminase; gdh: glutamate dehydrogenase; argC: N-acetyl-gamma-glutamyl-phosphate reductase; fdh: formate dehydrogenase; argJ: glutamate N-acetyltransferase; fhs: formate-tetrahydrofolate ligase; folD: 5,10-methylene-tetrahydrofolate dehydrogenase (NADP+); aceE: pyruvate dehydrogenase E1 component; suc: 2-oxoacid dehydrogenase acyltransferase.
Additional file 1 of Sleep patterns and potential risk factors for disturbed sleep quality in patients after surgery for infective endocarditis
Creators: name: Hu, Xiang-Ming
name: Wei, Wen-Ting
name: Huang, De-Yi
name: Lin, Cai-Di
name: Lu, Fen
name: Li, Xiao-Ming
name: Liao, Huo-Sheng
name: Yu, Zhi-Hong
name: Weng, Xiao-Ping
name: Wang, Shi-Bin
name: Hou, Cai-Lan
name: Jia, Fu-Jun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Fig. S1. The PSQI and ESS scores at 2 weeks after surgery during hospitalisation and at 6 months after surgery.
Obscene History. The Two Sedlmayrs
Creators: name: Verstegen, Ian
Publisher: name: Università degli Studi di Milano
Year: 2016

description: The following article proposes a new interpretation of Hans Sedlmayr’s politics, which thereby achieves a more successful understanding of his work. Seeking to reconcile pro­gressive and totalitarian elements of Sedlmayr’s thought, his stance is characterized as «Na­tional Bolshevist». Consistent with this view, there are two phases detected in Sedlmayr’s outlook, an early cosmopolitan phase and a later more symptomological cultural criticism. Seeking to nuance the complexity of politics in the 1930s, in the end it is nevertheless argued that it is impossible to link tightly Sedlmayr’s historical pronouncements with his politics.
description: Studia austriaca, Vol 24 (2016)
Multiscale Modeling of the Mechanical Behaviors and Failures of Additive Manufactured Titanium Metal Matrix Composites and Titanium Alloys Based on Microstructure Heterogeneity
Creators: name: Elkhateeb, Mohamed G
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 401401
subject: Additive manufacturing
classificationCode: 401406
subject: Machining
classificationCode: 401499
subject: Manufacturing engineering not elsewhere classified
classificationCode: 401799
subject: Mechanical engineering not elsewhere classified
classificationCode: 401706
subject: Numerical modelling and mechanical characterisation
classificationCode: 460207
subject: Modelling and simulation

description: This
study is concerned with the predictive modeling of the machining and the
mechanical behaviors of additive manufactured (AMed) Ti6AlV/TiC composites and
Ti6Al4V, respectively, using microstructure-based hierarchical multiscale
modeling. The predicted results could constitute as a basis for optimizing the
parameters of machining and AM of the current materials.

Through
hierarchical flow of material behaviors from the atomistic, to the microscopic
and the macroscopic scales, multiscale heterogeneous models (MHMs) coupled to
the finite element method (FEM) are employed to simulate the conventional and the
laser assisted machining (LAM) of Ti6AlV/TiC composites. In the atomistic
level, molecular dynamics (MD) simulations are used to determine the
traction-separation relationship for the cohesive zone model (CZM) describing
the Ti6AlV/TiC interface. Bridging the microstructures across the scales in
MHMs is achieved by representing the workpiece by macroscopic model with the
microscopic heterogeneous structure including the Ti6Al4V matrix, the TiC
particles, and their interfaces represented by the parameterized CZM. As a
result, MHMs are capable of revealing the possible reasons of the peculiar high
thrust forces behavior during conventional machining of Ti6Al4V/TiC composites,
and how laser assisted machining can improve this behavior, which has not been
conducted before.

Extending MHMs to predict the mechanical
behaviors of AMed Ti6Al4V would require including the heterogeneous
microstructure at the grain level, which could be computational expensive. To
solve this issue, the extended mechanics of structure genome (XMSG) is
introduced as a novel multiscale homogenization approach to predict the
mechanical behavior of AMed Ti6Al4V in a computationally efficient manner. This
is realized by embedding the effects of microstructure heterogeneity, porosity
growth, and crack propagation in the multiscale calculations of the mechanical
behavior of the AMed Ti6Al4V using FEM. In addition, the XMSG can predict the
asymmetry in the Young’s modulus of the AMed Ti6Al4V under tensile and
compression loading as well as the anisotropy in the mechanical behaviors. The
applicability of XMSG to fatigue life prediction with valid results is
conducted by including the energy dissipations associated with cyclic
loading/unloading in the calculations of the cyclic response of the material.
Additional file 1 of NGS data vectorization, clustering, and finding key codons in SARS-CoV-2 variations
Creators: name: Kim, Juhyeon
name: Cheon, Saeyeon
name: Ahn, Insung
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1. Result graphs for additional dimensionality reduction techniques, tables containing more detailed information about data, and additional information about experimental results are provided.
Oxaliplatin pharmacokinetics on hemodialysis in a patient with diffuse large B cell lymphoma
Creators: name: Balzer, Michael S.
name: Eggers, Hendrik
name: Heuser, Michael
name: Reising, Ansgar
name: Ganser, Arnold
name: Haller, Hermann
name: Bertram, Anna
Publisher: name: F1000Research
Year: 2016

description: Introduction	Oxaliplatin is widely used in diverse anticancer regimens. Elimination occurs mainly by the kidneys, clearance strongly correlates with GFR.	CKD and ESRD patients are especially prone to accumulation and drug- related toxicity.	The role of extra-corporal RRT in oxaliplatin clearance is not clear. Pharmacokinetic data is limited to single HD cycles. No data is available on the absolute clearance of oxaliplatin by HD.	HD dose as a parameter of oxaliplatin clearance has not been studied so far.Methods	Sample collection included spent dialysate, ultrafiltrate, serum before and after HD as well as pre- and post-dialyzer after 15, 0, 120, 180 and 240 min of HD.	Total serum platinum concentrations were quantified by inductively coupled plasma mass spectrometry.	HD was performed as high-flux bicarbonate dialysis (GENIUS® dialysis system, F60S polysulfone high-flux dialyzer, both Fresenius Medical Care, Bad Homburg, Germany; blood flow (Qb) and dialysate flow (Qd) rates 250 mL/min).	Dialyzer clearance (CLdial) was calculated from pre- (Ca) and postfilter (Cv) serum drug concentrations: CLdial = plasma perfusion rate (Qb × (1−hematocrit)) × extraction ratio ((Ca−Cv)/Ca).Case report	Oxaliplatin is widely used in diverse anticancer regimens. Elimination occurs mainly by the kidneys, clearance strongly correlates with GFR.	A 61-year-old anuric HD patient was referred to our tertiary care hospital in April 2014 with cervical, supraclavicular, and retroperitoneal lymphadenopathy.	Histology revealed follicular lymphoma grade 3A, stage IIIA.	Due to additional cardiovascular comorbidity, the patient received six courses of rituximab and bendamustine, which led to partial remission as best response.	Despite rituximab maintenance, clinical relapse with recurrence in the known localisations plus splenic infiltration and histopathological transformation to diffuse large B cell lymphoma occurred in September 2015.	Second-line treatment with rituximab, gemcitabine, and oxaliplatin was chosen.	Because of ESRD secondary to polycystic kidney disease requiring regular home HD since 2002 and lack of evidence for long-term oxaliplatin clearance, dosage of oxaliplatin was reduced to 50 mg/m2 (50% reduction, Fig. 1).Disclaimer	Informed consent was obtained from the patient.	This work has meanwhile been published in Annals of Hematology: Ann Hematol 2016;95: 649-650.Conclusion	Similarly to patients with normal GFR, daily dialysis over five consecutive days was able to reduce serum platinum below 50% of Cmax.	Oxaliplatin clearance by daily HD efficiently reduces platinum levels to non- toxic levels (Cmin 435 μg/L after 5 days and 273 μg/L after 14 days), which should be incorporated into dose adjustment concepts.	Showing a partial response after 3 cycles, we can also conclude antitumoral therapeutic effectiveness.