cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The experience of falls and fall risk during the subacute phase of spinal cord injury: a mixed methods study
Creators: name: Perez, Olinda Habib
name: Chan, Katherine
name: Martin, Samantha
name: Marinho-Buzelli, Andresa
name: Singh, Hardeep
name: Musselman, Kristin E.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: To understand the circumstances, causes and consequences of falls experienced by individuals with subacute SCI, and to explore their perspectives on how falls/fall risk impacted their transition to community living. Sixty adults with subacute SCI participated. A sequential explanatory mixed methods design was adopted. In Phase I, falls were monitored for six months post-inpatient rehabilitation discharge through a survey. In Phase II, a qualitative focus group (n = 5) was held to discuss participants’ perspectives on Phase I results and falls/fall risk. Descriptive statistics and thematic analysis were used to analyze Phase I and II data, respectively. Falls commonly occurred in the daytime, at home and about half resulted in minor injury. Three themes reflecting participants’ perspectives were identified in Phase II. 1) Lack of preparedness to manage fall risk upon returning home from inpatient rehabilitation. 2) Adjusting to increased fall risk following discharge from inpatient rehabilitation. 3) Psychological impact of the transition to living at home with an increased fall risk. The findings highlight the need for fall prevention initiatives during subacute SCI, when individuals are learning to manage their increased fall risk. Falls are common in the subacute phase of spinal cord injury (SCI), with falls commonly occurring in the daytime at home while walking or changing positions and resulting in minor injury.Individuals living with SCI feel unprepared to manage the increased fall risk experienced after discharge from inpatient rehabilitation, and the possibility of falling can cause anxiety and fear.Following the transition from inpatient rehabilitation to living at home, individuals with SCI would like continued support from health professionals and/or peers to prevent falls and adjust to living independently with SCI. Falls are common in the subacute phase of spinal cord injury (SCI), with falls commonly occurring in the daytime at home while walking or changing positions and resulting in minor injury. Individuals living with SCI feel unprepared to manage the increased fall risk experienced after discharge from inpatient rehabilitation, and the possibility of falling can cause anxiety and fear. Following the transition from inpatient rehabilitation to living at home, individuals with SCI would like continued support from health professionals and/or peers to prevent falls and adjust to living independently with SCI.
Detecting glacial refugia in the Southern Ocean
Creators: name: SCY Lau
name: NG Wilson
name: CNS Silva
name: Strugnell, Jan
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 The Authors. Ecography published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos Throughout the Quaternary, the continental-based Antarctic ice sheets expanded and contracted repeatedly. Evidence suggests that during glacial maxima, grounded ice eliminated most benthic (bottom-dwelling) fauna across the Antarctic continental shelf. However, paleontological and molecular evidence indicates most extant Antarctica benthic taxa have persisted in situ throughout the Quaternary. Where and how the Antarctic benthic fauna survived throughout repeated glacial maxima remain mostly hypothesised. If understood, this would provide valuable insights into the ecology and evolution of Southern Ocean biota over geological timescales. Here we synthesised and appraised recent studies and presented an approach to demonstrate how genetic data can be effective in identifying where and how Antarctic benthic fauna survived glacial periods. We first examined the geological and ecological evidence for how glacial periods influenced past species demography in order to provide testable frameworks for future studies. We outlined past ice-free areas from Antarctic ice sheet reconstructions that could serve as glacial refugia and discussed how benthic fauna with pelagic or non-pelagic dispersal strategies moved into and out of glacial refugia. We also reviewed current molecular studies and collated proposed locations of Southern Ocean glacial refugia on the continental shelf around Antarctica, in the deep sea, and around sub-Antarctic islands. Interestingly, the proposed glacial refugia based on molecular data generally do not correspond to the ice-free areas identified by Antarctic ice sheet reconstructions. The potential biases in sampling and in the choice of molecular markers in current literature are discussed, along with the future directions for employing testable frameworks and genomic methods in Southern Ocean molecular studies. Continued data syntheses will elucidate greater understanding of where and how Southern Ocean benthic fauna persisted throughout glacial periods and provide insights into their resilience against climate changes in the future.
Antitumor and antioxidant activity of Escherichia coli is accompanied by changes in the L-arginine dichotomous pathways in peritoneal and blood leukocytes following Ehrlich ascites carcinoma
Creators: name: Alchujyan, N. Kh.
name: Movsesyan, H. A.
name: Aghababova, A. A.
name: Guevorkyan, A. G.
name: Movsesyan, N. H.
name: Khachatryan, H. F.
name: Barseghyan, V. H.
name: Hairapetyan, H. L.
name: Sahakyan, L. S.
name: Avanesyan, L. G.
name: Melkonyan, L. H.
name: Barseghyan, K. A.
name: Kevorkian, G. A.
Publisher: name: European Chemical Bulletin
Year: 2015

description: The effectiveness and mechanisms of antitumor activity of non-pathogenic Escherichia coli EM0 strain using mouse model of Ehrlich ascites carcinoma (EAC) is studied. 48 h after inoculating EAC cells, a single noninvasive treatment of the 2-month-old male white mice’s eyes and mouths with live E. coli isolate increased the life span by 75% (P<0.001). Furthermore, a significant decrease in the volume of ascites fluid (66.5 %, P<0.01) was determined, accompanied by down-regulation of EAC-activated lipid peroxidation processes and changes in the L-arginine metabolic profile in leukocytes as early as within 9 days of post-treatment compared to non-treated EAC-bearing mice. We found EAC-induced stimulation of arginase and nitric oxide synthase (NOS) activity correlated with the levels of their common substrate, L-arginine and products (arginase-derived L-ornithine and NOS-derived NO and L-citrulline) in the cytoplasm and mitochondria of peritoneal and blood leukocytes. The biochemical pattern was differentially modulated by E.coli treatment depending on whether leukocytes were localized in the ascitic fluid or the peripheral blood. E. coli concentrated in the ascitic fluid directly affected the surrounding cells including peritoneal leukocyte in which it decreased the activity of two arginase isoforms and a total NOS in the cytoplasm. Negligible number of E coli at sites remote of tumor suggests its indirect effects particularly via stimulation of LPS-mediated non-specific immune response associated with activation of arginase and NOS in the cytoplasm of blood leukocytes. The data obtained should be taken into account in the further study aimed to use non-pathogenic E. coli strains in the adjuvant therapy of ascites tumors.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
Supplemental Material, sj-pdf-1-tva-10.1177_1524838020961879 - Indigenous People’s Experiences and Expectations of Health Care Professionals When Accessing Care for Family Violence: A Qualitative Evidence Synthesis
Creators: name: Fiolet, Renee
name: Cameron, Jacqui
name: Tarzia, Laura
name: Gallant, David
name: Hameed, Mohajer
name: Hooker, Leesa
name: Koziol-McLain, Jane
name: Glover, Karen
name: Spangaro, Joanne
name: Hegarty, Kelsey
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-1-tva-10.1177_1524838020961879 for Indigenous People’s Experiences and Expectations of Health Care Professionals When Accessing Care for Family Violence: A Qualitative Evidence Synthesis by Renee Fiolet, Jacqui Cameron, Laura Tarzia, David Gallant, Mohajer Hameed, Leesa Hooker, Jane Koziol-McLain, Karen Glover, Joanne Spangaro and Kelsey Hegarty in Trauma, Violence, & Abuse
Vitamin D3 loaded polycaprolactone nanoparticles enhance the expression of the antimicrobial peptide cathelicidin in macrophages
Creators: name: Dlozi, Prince N.
name: Ahmed, Rami
name: Khoza, Star
name: Dube, Admire
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Virology

description: Tuberculosis (TB), primarily caused by Mycobacterium tuberculosis, remains a global health burden. Current antibiotic treatments are limited by adverse effects, poor adherence, and drug resistance, necessitating new therapeutic approaches. Recent studies highlight the role of vitamin D3 (VD3) in enhancing host immune responses against the mycobacterium via cathelicidin (an antimicrobial peptide) and autophagy activation. In this study, VD3-loaded poly-ƹ-caprolactone (PCL) nanoparticles (NPs) were synthesized to enhance cathelicidin expression in macrophages. NPs containing cholecalciferol, calcifediol, and calcitriol were synthesized using an emulsification solvent-evaporation technique. Average sizes of synthesized NPs ranged from 304.7 to 458.7 nm, with polydispersity index (PDI) and zeta potential (ZP) ranging from 0.103 to 0.257 and −17.3 to −7.47 mV, respectively. Encapsulation efficiencies were 9.68%, 10.99%, and 19.28% for cholecalciferol, calcifediol, and calcitriol, respectively. VD3-encapsulated NPs stimulated a dose-dependent increase in cathelicidin expression in THP-1 macrophages. Encapsulated calcifediol and calcitriol (100 ng/ml) induced the expression of 243.46 ng/ml ± 4.55 ng/ml and 396.67 ng/ml ± 25.24 ng/ml of cathelicidin, respectively, which was significantly higher than that induced by the free drugs. These findings suggest that NP encapsulation may offer a more efficient approach to using vitamin D3 for inducing cathelicidin expression as a host-directed treatment for TB.
TOTAL LIPIDS, PROTEINS, MINERALS AND ESSENTIAL OILS OF PINUS NIGRA ARNOLD AND PINUS SYLVESTRIS GROWING WILD IN KOSOVO
Creators: name: Faiku, Fatmir
name: Haziri, Arben
name: Gashi, Fatbardh
name: Troni, Naser
name: Faiku, Haxhere
Publisher: name: European Chemical Bulletin
Year: 2015

description: The soil and climatic conditions allow the growth of a lot of medical herbs in Kosovo. Lipids, proteins, minerals and essential oils were quantitatively determined from the Pinus nigra Arnold and Pinus sylvestris growing wild in Germia Park (located in the north-east of Pristina). Total proteins were analyzed, by Kjeldahl method. The total amount of proteins in Pinus nigra Arnold is 7.714 % and in Pinus sylvestris is 4.375 %. Lipids are analyzed by Soxhlet extraction. The total amount of lipids in Pinus nigra Arnold are 7.185 % and in Pinus sylvestris 6.670 %. Essential oils were isolated using steam distillation. The total amount of essential oils in Pinus nigra Arnold are 0.35 % and in Pinus sylvestris 0.32 %. The mineral content was studied and analyzed by flame atomic absorption spectrometry. Six elements, sodium, potassium, calcium, zinc, iron and copper were determined in Pinus nigra Arnold and Pinus sylvestris. The mean levels of sodium, potassium, calcium, zinc, iron and copper are 0.0246 %, 0.128 %, 0.426 %, 1.72 x10-3 %, 0.0173 %, 3.83 x10-4 % in Pinus nigra Arnold, respectively. The mean levels of sodium, potassium, calcium, zinc, iron and copper are 6.9 x10-4 %, 0.042 %, 0.118 %, 9.5 x10-3 %, 0.084 %, 1.9 x10-3 % in Pinus sylvestris, respectively. Calcium and potassium are present in large amounts of Pinus nigra Arnold while calcium and iron to Pinus sylvestris.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
PGRMC1 Phosphorylation Affects Cell Shape, Motility, Glycolysis, Mitochondrial Form and Function, and Tumor Growth
Creators: name: Thejer, BM
name: Adhikary, PP
name: Kaur, A
name: Teakel, SL
name: Van Oosterum, A
name: Seth, I
name: Pajic, M
name: Hannan, KM
name: Pavy, M
name: Poh, P
name: Jazayeri, JA
name: Zaw, T
name: Pascovici, D
name: Ludescher, M
name: Pawlak, M
name: Cassano, JC
name: Turnbull, L
name: Jazayeri, Mitra
name: James, AC
name: Coorey, CP
name: Roberts, TL
name: Kinder, SJ
name: Hannan, RD
name: Patrick, E
name: Molloy, MP
name: New, EJ
name: Fehm, TN
name: Neubauer, H
name: Goldys, EM
name: Weston, LA
name: Cahill, MA
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Background: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Results: We demonstrate that manipulating PGRMC1 phosphorylation status in MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental cells over-expressing hemagglutinin-tagged wild-type (WT) PGRMC1-HA, cells expressing a PGRMC1-HA-S57A/S181A double mutant (DM) exhibited reduced levels of proteins involved in energy metabolism and mitochondrial function, and altered glucose metabolism suggesting modulation of the Warburg effect. This was associated with increased PI3K/AKT activity, altered cell shape, actin cytoskeleton, motility, and mitochondrial properties. An S57A/Y180F/S181A triple mutant (TM) indicated the involvement of Y180 in PI3K/AKT activation. Mutation of Y180F strongly attenuated subcutaneous xenograft tumor growth in NOD-SCID gamma mice. Elsewhere we demonstrate altered metabolism, mutation incidence, and epigenetic status in these cells. Conclusions: Altogether, these results indicate that mutational manipulation of PGRMC1 phosphorylation status exerts broad pleiotropic effects relevant to cancer and other cell biology.
sj-pdf-3-eex-10.1177_2515127420969957 - Supplemental material for Developing Educational Escape Rooms for Experiential Entrepreneurship Education
Creators: name: Martina, Richard A.
name: Göksen, Sultan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-4-eex-10.1177_2515127420969957 for Developing Educational Escape Rooms for Experiential Entrepreneurship Education by Richard A. Martina and Sultan Göksen in Entrepreneurship Education and Pedagogy
CHANGES IN THE CONTENT OF SUGARS AND ORGANIC ACIDS DURING RIPENING OF COFFEA ARABICA AND COFFEA CANEPHORA FRUITS
Creators: name: Koshiro, Yukiko
name: Jackson, Mel C.
name: Nagai, Chifumi
name: Ashihara, Hiroshi
Publisher: name: European Chemical Bulletin
Year: 2015

description: Changes in concentration (% of dry weight) and content (mg/organ) of sucrose, glucose, fructose and some organic acids in pericarps and seeds of Coffea arabica cv. Mokka, C. arabica cv. Catimor and C. canephora were monitored during the development and ripening of fruits. The coffee fruits were categorized into five stages 1 to 5 which corresponded to young, developing, fully-developed (green), ripening (pink) and fully-ripened (red) fruits, respectively. In all samples, the major sugars in young fruits (stage 1) were fructose (~5% dry weight) and glucose (~3% dry weight). Significant amounts of sucrose were also found in the later stages of development. The concentration of sucrose in ripened pericarp and seeds (stage 5) in two cultivars of C. arabica (19-25% of dry weight in pericarp and 8‒18% in seeds) was higher than those in C. canephora (8% in pericarp and 5% in seeds). Sucrose was accumulated exclusively in seeds of two cultivars of C. arabica. In contrast, both sucrose and the reducing sugars, fructose and glucose, accumulated in pericarps of all coffee samples and in seeds of C. canephora. The concentration of malic acid, citric acid, lactic acid, oxalic acid and quinic acid changed during development and ripening of fruits. The values of most organic acid fluctuated between 0‒1%, except for a transient, high content of quinic acid (>2%) in young fruits. Characteristic accumulation patterns of organic acids were found in different organs; citric acid concentration was high in seeds, but malic acid or oxalic acid was high in pericarps. Possible metabolic routes of metabolites are discussed.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
«progetto Pedianet»: L'informatica in Pediatra
Creators: name: Barbieri, Elisa
Publisher: name: Zenodo
Year: 2024

description: The Pedianet network…where all started

The Pedianet network throught the years

The Pedianet network now

Management Structure

The Pedianet Database

The Pedianet Database: some numbers for 2011-2021

Potential: from research…

Potential: to public health tool.…

Potential: to health outcomes evaluation tool..

Potential: to clinical support tool…

The future: lessons from the hospital setting
Identifiers and labels for everyone: recent developments in Symbiota
Creators: name: Rocha Prado, Laura
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Identifiers and labels for everyone: recent developments in Symbiota by Biodiversity Informatician Laura Rocha Prado of Biodiversity Informatician Symbiota Support Hub Tempe United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
INVESTIGATION ON ENHANCED MICROWAVE DEMULSIFICATION USING INORGANIC SALTS
Creators: name: Miadonye, Adango
name: Shanshan, Lin
Publisher: name: European Chemical Bulletin
Year: 2015

description: While the formation of water-in-crude oil (W/O) emulsion is identified to cause serious problems in petroleum industry such as decreasing the oil recovery efficiency, increasing pumping cost, and generating pipeline corrosion, much of its treatment has been focused mostly on gravity separation by mechanical/chemical technology. As an integral part in the process of oil production and transportation, crude oil demulsification has become a significant research attention. Microwave has also long been employed to crude oil demulsification based on the fact that microwave heating can dissipate heat in aqueous medium and raise the energy of the molecules rapidly. However, the research on salts-assisted microwave demulsification has been limited to salts mostly identified in produce-water. The aim of this work is to carry out a comprehensive research on the effect of microwave demulsification and the influence of a variety of inorganic salts to the microwave process. Also, a comparative study on microwave demulsification between heavy oil and light oil were conducted. The obtained results revealed water separation of 47% between irradiated and non-irradiated emulsion for heavy crude oil compared to 13% for light crude oil. Also the effect of different inorganic salts and its optimum amount to promote demulsification were identified.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
Enhanced cartilage repair using gelatin methacryloyl hydrogels combined with icariin and magnesium-doped bioactive glass
Creators: name: Liao, Shiyao
name: Zhou, Kai
name: Kang, Yao
name: Zhao, Tingxiao
name: Lin, Yicheng
name: Lv, Jun
name: Zhu, Danjie
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Cartilage repair remains challenging due to limited self-healing, poor biocompatibility, and insufficient mechanical properties of current materials. To overcome these issues, we developed a multifunctional composite hydrogel by integrating gelatine methacrylate (GelMA) with magnesium-doped bioactive glass (Mg-BG) and icariin (ICA). SEM analysis revealed that pure GelMA exhibited a highly porous yet loosely organized structure, whereas the addition of Mg-BG and ICA produced a denser, more interconnected porous network that enhances cell adhesion and nutrient diffusion. In vitro, the ICA/Mg-BG/GelMA hydrogel achieved a swelling ratio up to 430% and maintained cell viability above 80% over 5 days. Moreover, qRT-PCR and immunohistochemical analyses demonstrated that the composite hydrogel upregulated chondrogenic markers (SOX9, ACAN, and COL2A1) compared with GelMA alone. Specifically, it downregulates M1 pro-inflammatory markers (CCR7, iNOS, CD86) and upregulates M2 anti-inflammatory markers (ARG1, CD163, CD206), thereby creating a regenerative microenvironment. These results indicate that the synergistic combination of GelMA, Mg-BG, and ICA not only improves the scaffold’s mechanical support but also enhances its biological functionality, offering a promising strategy for cartilage repair. Future studies will focus on in vivo validation to further assess its clinical potential.
TOTAL LIPIDS, PROTEINS, MINERALS, ESSENTIAL OILS AND ANTIOXIDANT ACTIVITY OF THE ORGANIC EXTRACTS OF MENTHA LONGIFOLIA (L.) GROWING WILD IN KOSOVO
Creators: name: Faiku, Fatmir
Publisher: name: European Chemical Bulletin
Year: 2015

description: The soil and climatic conditions are conducive for the growth of a lot of medical herbs in Kosovo. Mentha longifolia (L.) is native to Europe, Central Asia and Australia. Lipids, proteins, minerals and essential oils were quantitatively determined from theMentha longifolia (L.) growing wild in Germia Park (located in the northeast of Pristina). Total proteins were analyzed, by Kjeldahl method. The total amount of proteins in the Mentha longifolia (L.) is 8.227 %. Lipids are analyzed by Soxhlet extraction. The total amount of lipids in the Mentha longifolia (L.) are 5.804 %. Essential oils were isolated using steam distillation. The total amount of essential oils in the Mentha longifolia (L.) are 0.589 %. The mineral content was studied and analyzed by flame atomic absorption spectrometry. Six elements, sodium, potassium, calcium, zinc, iron and copper were determined in the Mentha longifolia (L.). The mean levels of sodium, potassium, calcium, zinc, iron and copper are 509.7 mg kg-1, 4055 mg kg-1, 9097 mg kg-1, 256.7 mg kg-1, 11841 mg kg-1, 82.83 mg kg-1 in the Mentha longifolia (L.), respectively. Iron and calcium are present in large amounts in the Mentha longifolia (L.). The antioxidant activity of essential oil was evaluated by means of the 2,2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging method. During the analysis of antioxidant activity of the extracts of Mentha longifolia (L) it has been observed that only H2O extract shows strong antioxidant activity than BHT and BHA.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
PupilDilationStudy_ResearcherSurveyUnredacted – Supplemental material for Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation
Creators: name: Szpernal, Jacob
name: Carroll, Joseph
name: Spellecy, Ryan
name: Groth, Jane A. Bachman
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, PupilDilationStudy_ResearcherSurveyUnredacted for Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation by Jacob Szpernal, Joseph Carroll, Ryan Spellecy and Jane A. Bachman Groth in Journal of Empirical Research on Human Research Ethics
Altered Caecal Neuroimmune Interactions in the Neuroligin-3(R451C) Mouse Model of Autism
Creators: name: Sharna, Samiha Sayed
name: Balasuriya, Gayathri K
name: Hosie, Suzanne
name: Nithianantharajah, Jess
name: Franks, Ashley
name: Hill-Yardin, Elisa L
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 5202
subject: Biological psychology

description: The intrinsic nervous system of the gut interacts with the gut-associated lymphoid tissue (GALT) via bidirectional neuroimmune interactions. The caecum is an understudied region of the gastrointestinal (GI) tract that houses a large supply of microbes and is involved in generating immune responses. The caecal patch is a lymphoid aggregate located within the caecum that regulates microbial content and immune responses. People with Autism Spectrum Disorder (ASD; autism) experience serious GI dysfunction, including inflammatory disorders, more frequently than the general population. Autism is a highly prevalent neurodevelopmental disorder defined by the presence of repetitive behavior or restricted interests, language impairment, and social deficits. Mutations in genes encoding synaptic adhesion proteins such as the R451C missense mutation in neuroligin-3 (NL3) are associated with autism and impair synaptic transmission. We previously reported that NL3R451C mice, a well-established model of autism, have altered enteric neurons and GI dysfunction; however, whether the autism-associated R451C mutation alters the caecal enteric nervous system and immune function is unknown. We assessed for gross anatomical changes in the caecum and quantified the proportions of caecal submucosal and myenteric neurons in wild-type and NL3R451C mice using immunofluorescence. In the caecal patch, we assessed total cellular density as well as the density and morphology of Iba-1 labeled macrophages to identify whether the R451C mutation affects neuro-immune interactions. NL3R451C mice have significantly reduced caecal weight compared to wild-type mice, irrespective of background strain. Caecal weight is also reduced in mice lacking Neuroligin-3. NL3R451C caecal ganglia contain more neurons overall and increased numbers of Nitric Oxide (NO) producing neurons (labeled by Nitric Oxide Synthase; NOS) per ganglion in both the submucosal and myenteric plexus. Overall caecal patch cell density was unchanged however NL3R451C mice have an increased density of Iba-1 labeled enteric macrophages. Macrophages in NL3R451C were smaller and more spherical in morphology. Here, we identify changes in both the nervous system and immune system caused by an autism-associated mutation in Nlgn3 encoding the postsynaptic cell adhesion protein, Neuroligin-3. These findings provide further insights into the potential modulation of neural and immune pathways.
sj-pdf-1-inc-10.1177_1751143720963757 - Supplemental material for Outcome measurement tools for communication, voice and speech intelligibility in the ICU and their clinimetric properties: A systematic review
Creators: name: Zaga, Charissa J
name: Cigognini, Bridie
name: Vogel, Adam P
name: Berney, Sue
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-inc-10.1177_1751143720963757 for Outcome measurement tools for communication, voice and speech intelligibility in the ICU and their clinimetric properties: A systematic review by Charissa J Zaga, Bridie Cigognini, Adam P Vogel and Sue Berney in Journal of the Intensive Care Society
IRES activation: HK2 and TPI1 glycolytic enzymes play a pivotal role in non-neuronal cell survival under hypoxia
Creators: name: Ismail, Rehana
name: Najar, Imtiyaz Ahmed
name: Rahamathulla, Mohamed
name: Hussain, Mahboob-Ul-
name: Banday, Muddasir Sharief
name: Devi, Sushma
name: Arora, Poonam
name: Kumar, Manish
name: Shivanandappa, Thippeswamy Boreddy
name: Ahmed, Mohammed Muqtader
name: Pasha, Ismail
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: Hypoxia-induced brain damage can cause consciousness, memory failure and death. HK2 and TPI1 were investigated to see how they change hypoxia sensitivity in neurons and non-neurons. Hypoxia sensitivity is determined by the differential overexpression of both important glycolytic enzymes in neuronal and non-neuronal cells. C6 glioma cells expressed greater HK2 and TPI1 protein than neuro 2A cells, which were more sensitive to hypoxia-induced cell death by MTT and lactate dehydrogenase leakage assay. After 48 h of hypoxia, C6 glioma cells displayed substantial protein upregulation of HK2 and TPI1 glycolytic proteins but not mRNA. Hypoxia did not raise HK2 and TPI1 mRNA transcription, pointing at post-transcriptional protein regulation. Using di-cistronic and promoter-less di-cistronic assays, we discovered significant IRES regions in HK2 and TPI1 mRNA’s 5′UTR, more active in C6 glioma cells with polypyrimidine tract binding (PTB) protein. We concluded that non-neuronal cells varied in HK2 and TPI1 overexpression, altering their vulnerability to hypoxia-induced cell death. Adjusting HK2, TP1 and PTB levels may prevent hypoxia-induced brain cell death. These results offer new information on glycolytic enzyme modulation under hypoxia, crucial for comprehending cell survival in hypoxic situations. This could affect situations like neurodegenerative illnesses or ischaemic injuries, where hypoxia-induced cell death is crucial.
Mechanisms for the removal of Cd(II) and Cu(II) from aqueous solution and mine water by biochars derived from agricultural wastes
Creators: name: Tharanga Dissanayaka Mudiyanselage
name: Jianming Xu
name: Potter, Ian
name: Franks, Ashley
name: JBAJ Chathurika
name: Caixian Tang
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Elsevier Ltd The capacity of biochars derived from agricultural wastes to remove Cd(II) and Cu(II) from aqueous solution and contaminated mine water was evaluated using laboratory-based batch sorption experiments. To examine immobilization of heavy metals, biochars produced in a commercial-scale mobile pyrolizer from feedstocks: poultry litter; lucerne shoot; vetch shoot; canola shoot; wheat straws; and sugar-gum wood, were tested in a liquid-based system. Biochars were characterized by FTIR, XPS and XRD before and after the mine water treatment. Lucerne biochar had the highest Langmuir sorption capacity of Cd(II) (6.28 mg g−1) and vetch-derived biochar had the highest Cu(II) sorption capacity (18.0 mg g−1) at pH 5.5. All the biochars exhibited higher sorption capacity for Cu(II) than for Cd(II). The smaller ionic radius and higher electronegativity of Cu(II), and the PO43−, CO32− and N-containing functional groups of biochars enhanced their binding affinity. The results demonstrated that poultry litter-derived biochar was effective at removal of the Cd(II) and Cu(II) from mine water up to the levels recommended by the World Health Organisation. The results revealed that precipitation with CO32− and PO43−, complexation with –OH and –COOH groups and electrostatic interaction with O-containing surface functional groups were the main mechanisms involved in the removal of multi-metals by biochars, and that selection of feedstock materials for biochar production is important to maximise remediation of multi-metals in contaminated water.
Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone
Creators: name: Owen, Katie L
name: LJ Gearing
name: Zanker, Damien J
name: Brockwell, Natasha
name: WH Khoo
name: DL Roden
name: M Cmero
name: S Mangiola
name: MK Hong
name: Spurling, Alex J
name: M McDonald
name: CL Chan
name: A Pasam
name: RJ Lyons
name: Duivenvoorden, Hendrika M
name: A Ryan
name: LM Butler
name: Mariadason, John
name: T Giang Phan
name: VM Hayes
name: S Sandhu
name: A Swarbrick
name: NM Corcoran
name: PJ Hertzog
name: PI Croucher
name: C Hovens
name: Parker, Belinda
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2020 Peter MacCallum Cancer Centre. Published under the terms of the CC BY NC ND 4.0 license The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in which cancer cells persist prior to overt lesion formation. Using single-cell transcriptomics and ex vivo profiling, we have uncovered the critical role of tumor-intrinsic immune signaling in the retention of cancer cell dormancy. We demonstrate that loss of tumor-intrinsic type I IFN occurs in proliferating prostate cancer cells in bone. This loss suppresses tumor immunogenicity and therapeutic response and promotes bone cell activation to drive cancer progression. Restoration of tumor-intrinsic IFN signaling by HDAC inhibition increased tumor cell visibility, promoted long-term antitumor immunity, and blocked cancer growth in bone. Key findings were validated in patients, including loss of tumor-intrinsic IFN signaling and immunogenicity in bone metastases compared to primary tumors. Data herein provide a rationale as to why current immunotherapeutics fail in bone-metastatic prostate cancer, and provide a new therapeutic strategy to overcome the inefficacy of immune-based therapies in solid cancers.
Table_1._The_physiological_parameters_among_different_groups_before,_during,_and_after_ischemia – Supplemental material for Agrin Involvement in Synaptogenesis Induced by Exercise in a Rat Model of Experimental Stroke
Creators: name: Pengyue Zhang
name: Liqiang Yang
name: Guangxiang Li
name: Yaju Jin
name: Danli Wu
name: Wang, Qing Mei
name: Peidong Huang
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, Table_1._The_physiological_parameters_among_different_groups_before,_during,_and_after_ischemia for Agrin Involvement in Synaptogenesis Induced by Exercise in a Rat Model of Experimental Stroke by Pengyue Zhang, Liqiang Yang, Guangxiang Li, Yaju Jin, Danli Wu, Qing Mei Wang and Peidong Huang in Neurorehabilitation and Neural Repair
Genetic Data and Climate Niche Suitability Models Highlight the Vulnerability of a Functionally Important Plant Species from South-Eastern Australia
Creators: name: AD Miller
name: C Nitschke
name: AR Weeks
name: WL Weatherly
name: Heyes, Simon
name: SJ Sinclair
name: OJ Holland
name: A Stevenson
name: Broadhurst, Linda
name: Hoebee, Susan
name: CDH Sherman
name: Morgan, John
Publisher: name: La Trobe
Year: 2020
Subjects: Uncategorized

description: © 2020 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd Habitat fragmentation imperils the persistence of many functionally important species, with climate change a new threat to local persistence due to climate niche mismatching. Predicting the evolutionary trajectory of species essential to ecosystem function under future climates is challenging but necessary for prioritizing conservation investments. We use a combination of population genetics and niche suitability models to assess the trajectory of a functionally important, but highly fragmented, plant species from south-eastern Australia (Banksia marginata, Proteaceae). We demonstrate significant genetic structuring among, and high level of relatedness within, fragmented remnant populations, highlighting imminent risks of inbreeding. Population simulations, controlling for effective population size (Ne), suggest that many remnant populations will suffer rapid declines in genetic diversity due to drift in the absence of intervention. Simulations were used to demonstrate how inbreeding and drift processes might be suppressed by assisted migration and population mixing approaches that enhance the size and connectivity of remnant populations. These analyses were complemented by niche suitability models that predicted substantial reductions of suitable habitat by 2080; ~30% of the current distribution of the species climate niche overlaps with the projected distribution of the species climate niche in the geographic region by the 2080s. Our study highlights the importance of conserving remnant populations and establishing new populations in areas likely to support B. marginata in the future, and adopting seed sourcing strategies that can help populations overcome the risks of inbreeding and maladaptation. We also argue that ecological replacement of B. marginata using climatically suited plant species might be needed in the future to maintain ecosystem processes where B. marginata cannot persist. We recommend the need for progressive revegetation policies and practices to prevent further deterioration of species such as B. marginata and the ecosystems they support.
Additional file 3 of Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients
Creators: name: Tornesello, Anna Lucia
name: Botti, Chiara
name: Micillo, Alberto
name: Labonia, Francesco
name: Arpino, Sergio
name: Isgrò, Maria Antonietta
name: Meola, Serena
name: Russo, Luigi
name: Cavalcanti, Ernesta
name: Sale, Silvia
name: Nicastro, Carmine
name: Atripaldi, Luigi
name: Starita, Noemy
name: Cerasuolo, Andrea
name: Reimer, Ulf
name: Holenya, Pavlo
name: Buonaguro, Luigi
name: Buonaguro, Franco M.
name: Tornesello, Maria Lina
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Table S3. Percentage of individuals who developed IgG response against N and S proteins of the seven human coronaviruses in each patient group.
Images on glass: Recovering hidden treasures of the University of Vienna's Zoological Collection
Creators: name: Engelberger, Simon
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Images on glass: Recovering hidden treasures of the University of Vienna's Zoological Collection by Simon Engelberger of Department Of Evolutionary Biology, University Of Vienna Vienna Austria for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
sj-pdf-1-bjo-10.1177_0308022620963746 - Supplemental material for Defining the role of occupational therapy with people living with and beyond cancer: Perspectives of British and Irish occupational therapists
Creators: name: Mackenzie, Lynette
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: 111702 Aged Health Care

description: Supplemental material, sj-pdf-1-bjo-10.1177_0308022620963746 for Defining the role of occupational therapy with people living with and beyond cancer: Perspectives of British and Irish occupational therapists by Lynette Mackenzie in British Journal of Occupational Therapy
Additional file 10 of Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients
Creators: name: Tornesello, Anna Lucia
name: Botti, Chiara
name: Micillo, Alberto
name: Labonia, Francesco
name: Arpino, Sergio
name: Isgrò, Maria Antonietta
name: Meola, Serena
name: Russo, Luigi
name: Cavalcanti, Ernesta
name: Sale, Silvia
name: Nicastro, Carmine
name: Atripaldi, Luigi
name: Starita, Noemy
name: Cerasuolo, Andrea
name: Reimer, Ulf
name: Holenya, Pavlo
name: Buonaguro, Luigi
name: Buonaguro, Franco M.
name: Tornesello, Maria Lina
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 10: Fig. S5. Barplot showing the fraction of serum signals reacting towards N and S proteins of MERS and common-cold coronaviruses obtained by setting the threshold above 10,000. Control samples are reaction controls with the secondary antibody only (n=3), the PDC identifies samples from SARS-CoV-2 positive children, INT identifies samples from adults with mild/moderate symptoms and HOS the hospitalized patients with severe symptoms. Samples labeled as VAX-B1, VAX-B2 and VAX-B3 are each a pool of sera from 10 vaccinated subjects.
PREDICTION OF VAPOUR-LIQUID EQUILIBRIUM FOR N-ALKANE FLUIDS
Creators: name: Akhouri, B P
name: Akhtar, K
name: Akhouri, T P
Publisher: name: European Chemical Bulletin
Year: 2016

description: Analysis of the equations of state of the hard convex body chain and hard spheres has been done for predicting the vapor liquid equilibrium of simple fluids of n-alkanes. The repulsive part of the Boublik equation of state for the hard convex body chain has been found as an equivalent alternative either for the well known Carnahan-Starling repulsive term or the established van der Waals repulsive part of hard spheres equations of state. The attractive parts of these equations of state have the similar form as that of the van der Waals and are obeying the power-law temperature dependency. Add-on separation method of compressibility factor has been used for these equations of state. The simulated data for VLE densities from these equations of state are found to agree well with the available experimental data for n-alkane fluids.
description: European Chemical Bulletin, Vol 4, No 10-12 (2015): European Chemical Bulletin
FAIR-EASE: MS06 - FAIR-EASE initial evaluation of the FAIRness of digital resources and services
Creators: name: PIERKOT Christelle
name: VERNET Marine
Publisher: name: Zenodo
Year: 2023

description: The INFRA-EOSC Horizon Europe FAIR-EASE project aims to improve the discovery, access, and useof multidisciplinary data for the earth system that represent heterogeneous and distributedinformation from the environment to biodiversity, through the development of distributed andintegrated services.It is therefore primordial not only to ensure that the data and digital resources offered throughthese services meet the FAIR principles but also that all research outputs of the project, includingthe services themselves, implement these recommendations.Within WP6 (Work Package), task 6.3 is dedicated to the application and endorsement of the FAIRprinciples.The first activity of Task 6.3 was to assess research data and software expected to be reused in theproject, in order to obtain an overview of their level of FAIRness, identify possible improvements,and draft recommendations in terms of FAIRisation of the various research objects, to be taken intoaccount when developing FAIR-EASE services.This preliminary action was carried out from April to June 2023, involving FAIR-EASE WP5 Pilots(which are described in FAIR-EASE deliverable D5.1) and project partners involved in theproduction of research software serving as building blocks for FAIR-EASE services.This report describes the objectives and the methodology applied, as well as the results of thisevaluation and first recommendations.
Andersen_Supplemental_Material – Supplemental material for Playing With Fear: A Field Study in Recreational Horror
Creators: name: Andersen, Marc Malmdorf
name: Schjoedt, Uffe
name: Price, Henry
name: Rosas, Fernando E.
name: Coltan Scrivner
name: Clasen, Mathias
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, Andersen_Supplemental_Material for Playing With Fear: A Field Study in Recreational Horror by Marc Malmdorf Andersen, Uffe Schjoedt, Henry Price, Fernando Rosas, Coltan Scrivner and Mathias Clasen in Psychological Science
SATURATION AND WATTABILITY EVOLUTION UNDER NON-ISOTHERMAL CARBON DIOXIDE INJECTION INTO SALINE AQUIFER
Creators: name: Miadonye, Adango
name: Amadu, Mumuni
Publisher: name: European Chemical Bulletin
Year: 2016

description: To reduce the cost of carbon capture, transportation and eventual geologic storage at potential geologic sites future sequestration plans envisage the locating of power plants at potential geologic sites. The implication is that the injection temperature of flue gas will be typically those encountered in combustion power plants. This, obviously has a geomechanical consequence considering the fact that heat transferred from the aquifer to the low permeability cap rock will cause excessive pore pressure build up due to poor pore pressure diffusion characteristics of these rocks. While these low permeability rocks are required to provide stratigraphic trapping mechanisms such excessive pore pressure build up can result in compromising the geomechanical integrity.
This paper has used heat transfer theories and geomechanical concepts to obtain steady state temperature distribution in cap rocks for temperatures ranging from 50 to 800 degrees Celsius. In so doing, cap rock critical temperatures for tensile and shear failures have been established for a potential on-site gas injection into saline aquifers.
description: European Chemical Bulletin, Vol 4, No 10-12 (2015): European Chemical Bulletin
Antiparasitic and antimicrobial activity of Ipomoea palmata against Toxoplasma gondii and Staphylococcus aureus: correlation with major phenolics identified by HPLC
Creators: name: Mira, Amira
name: Aljarba, Tariq M.
name: Bar, Fatma M. Abdel
name: Ahmed, Rehab
name: Negm, Walaa A.
name: Elekhnawy, Engy
name: El-Seadawy, Hosam M.
name: Elmorsy, Eman A.
name: Younis, Salwa S.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Toxoplasma gondii, a protozoan parasite found in water sources, causes toxoplasmosis, with no current protocols for inactivating its oocysts in water. Staphylococcus aureus, a significant bacterial pathogen, is known for causing various illnesses, including skin infections and biofilm-related diseases. This study investigated the antibacterial and antiparasitic properties of Ipomoea palmata leaf extract, rich in phenolics, against T. gondii tachyzoites and S. aureus. I. palmata extract significantly reduced tachyzoites count in peritoneal fluids and liver smears of infected mice with alleviation of toxoplasmosis-induced hepatitis. SEM showed surface irregularities in tachyzoites from treated groups. The extract demonstrated antibacterial action against S. aureus with a minimum inhibitory concentration of 128 to 512 µg/mL, reduced biofilm formation from 69.23% to 15.38% of tested isolates, and downregulated biofilm genes (cna, fnbA, and ica) in 53.85% of isolates. Treatment with I. palmata extract improved liver architecture, reduced inflammation, and eliminated blood vessel congestion. The main phenolic acids identified by HPLC/UV analysis were chlorogenic acid, gallic acid, ellagic acid, and methyl gallate, while the predominant flavonoids were apigenin, quercetin, and naringenin. These findings highlight the potential of I. palmata extract as a natural antimicrobial and antiparasitic agent, warranting further research to isolate and evaluate its active compounds.