cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
When, Where and How Osteoporosis-Associated Fractures Occur: An Analysis from the Global Longitudinal Study of Osteoporosis in Women (GLOW)
Creators: name: Costa, Aline G.
name: Wyman, Allison
name: Siris, Ethel S.
name: Watts, Nelson B.
name: Silverman, Stuart
name: Saag, Kenneth G.
name: Roux, Christian
name: Rossini, Maurizio
name: Pfeilschifter, Johannes
name: Nieves, Jeri W.
name: Netelenbos, J. Coen
name: LaCroix, Andrea Z.
name: March, Lyn
name: Hooven, Frederick H.
name: Greenspan, Susan L.
name: Gehlbach, Stephen H.
name: Díez-Pérez, Adolfo
name: Cooper, Cyrus
name: Compston, Juliet E.
name: Chapurlat, Roland D.
name: Boonen, Steven
name: Anderson Jr, Frederick A.
name: Adachi, Jonathan D.
name: Adami, Silvano
Publisher: name: Columbia University
Year: 2013
Subjects: Seasons
Osteoporosis
Hip joint--Fractures
Public health

description: Objective

To examine when, where and how fractures occur in postmenopausal women.

Methods

We analyzed data from the Global Longitudinal Study of Osteoporosis in Women (GLOW), including women aged ≥55 years from the United States of America, Canada, Australia and seven European countries. Women completed questionnaires including fracture data at baseline and years 1, 2 and 3.

Results

Among 60,393 postmenopausal women, 4122 incident fractures were reported (86% non-hip, non-vertebral [NHNV], 8% presumably clinical vertebral and 6% hip). Hip fractures were more likely to occur in spring, with little seasonal variation for NHNV or spine fractures. Hip fractures occurred equally inside or outside the home, whereas 65% of NHNV fractures occurred outside and 61% of vertebral fractures occurred inside the home. Falls preceded 68–86% of NHNV and 68–83% of hip fractures among women aged ≤64 to ≥85 years, increasing with age. About 45% of vertebral fractures were associated with falls in all age groups except those ≥85 years, when only 24% occurred after falling.

Conclusion

In this multi-national cohort, fractures occurred throughout the year, with only hip fracture having a seasonal variation, with a higher proportion in spring. Hip fractures occurred equally within and outside the home, spine fractures more often in the home, and NHNV fractures outside the home. Falls were a proximate cause of most hip and NHNV fractures. Postmenopausal women at risk for fracture need counseling about reducing potentially modifiable fracture risk factors, particularly falls both inside and outside the home and during all seasons of the year.
Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy
Creators: name: Zhou, Wendi
name: Liu, Xiyong
name: Chen, Yih-Wen
name: Chu, Peiguo
name: Loria, Sofia
name: Wang, Yafan
name: Yen, Yun
name: Chou, Kai-Ming
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Squamous cell carcinoma
subject: Head--Cancer--Treatment
subject: DNA polymerases
subject: Genetics
subject: FOS: Biological sciences

description: Purpose:
The development of resistance against anticancer drugs has been a persistent clinical problem for the treatment of locally advanced malignancies in the head and neck mucosal derived squamous cell carcinoma (HNSCC). Recent evidence indicates that the DNA translesion synthesis (TLS) polymerase η (Pol η; hRad30a gene) reduces the effectiveness of gemcitabine/cisplatin. The goal of this study is to examine the relationship between the expression level of Pol η and the observed resistance against these chemotherapeutic agents in HNSCC, which is currently unknown.

Methods:

Sixty-four mucosal derived squamous cell carcinomas of head and neck (HNSCC) from 1989 and 2007 at the City of Hope National Medical Center (Duarte, CA) were retrospectively analyzed. Pretreatment samples were immunostained with anti-Pol η antibody and the correlation between the expression level of Pol η and clinical outcomes were evaluated. Forty-nine cases treated with platinum (n=40) or gemcitabine (n=9) based chemotherapy were further examined for Pol η expression level for comparison with patient response to chemotherapy.

Results:

The expression of Pol η was elevated in 67% of the head and neck tumor samples. Pol η expression level was significantly higher in grade 1 to grade 2 tumors (well to moderately differentiated). The overall benefit rate (complete response+ partial response) in patients treated with platinum and gemcitabine based chemotherapy was 79.5%, where low Pol η level was significantly associated with high complete response rate (p=0.03), although not associated with overall survival. Furthermore, no significant correlation was observed between Pol η expression level with gender, age, tobacco/alcohol history, tumor stage and metastatic status.

Conclusions:

Our data suggest that Pol η expression may be a useful prediction marker for the effectiveness of platinum or gemcitabine based therapy for HNSCC.
Women's Occupational Health Resource Center News, Volume 4, Number 2
Creators: name: Women's Occupational Health Resource Center
Publisher: name: Columbia University
Year: 1982
Subjects: Women employees
Video display terminals--Safety measures
Abnormalities, Human--Prevention
Industrial safety
Public health
Medicine, Industrial

description: Newsletter dated March/April 1982 produced by the Women’s Occupational Health Resource Center (WOHRC).The WOHRC (1979-1987) was a research and training program devoted to identifying and better understanding hazards faced by women workers. WOHRC was housed in Columbia’s School of Public Health and directed by Professor Jeanne Mager Stellman. WOHRC was a designated OSHA New Directions Training program, and also received support from other federal and private agencies. As a New Directions project, WOHRC trained thousands of workers and professionals in hazard recognition and accident and illness prevention for women workers. In order to carry out its public health programs, WOHRC developed and disseminated original educational materials. The materials were designed to be authoritative while at the same time accessible to non-professional users (e.g. the workers). WOHRC published a monthly newsletter that contained a “fact sheet” focusing on a particular job or a particular hazard. This issue features articles titled "Canadian Government Employees Win Important VDT Safeguards" and "Bill To Prevent Birth Defects Drafted by Ecology Group". The fact sheets were also made available individually or collected into “fact packs” of related materials.
Η Προστασία των Δεδομένων Προσωπικού χαρακτήρα και η ασφάλεια κατά την ενσωμάτωση των Τεχνολογιών Πληροφορικής και Επικοινωνιών (ΤΠΕ) στις έξυπνες πόλεις
Creators: name: Κοντόπουλος, Φώτιος Γρηγορίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2025
Subjects: Smart City
Information and Communication Technologies-ICT
Internet of Things
Big Data
Open Data
Cloud Computing
Artificial Intelligence
Personal Data
General Data Protection Regulation
Data Security

description: Η τεχνολογική πρόοδος επηρεάζει όλες τις πτυχές της ζωής μας, με τη διείσδυση των Τεχνολογιών Πληροφορικής και Επικοινωνιών (ΤΠΕ) να είναι καθοριστική στην προσωπική, επαγγελματική και κοινωνική ζωή. Σημαντικό πεδίο αυτής της εξέλιξης είναι οι έξυπνες πόλεις (Smart Cities), που υποστηρίζουν τη βιώσιμη ανάπτυξη και τη βελτίωση της ποιότητας ζωής των κατοίκων, αξιοποιώντας συνδεδεμένες συσκευές και αισθητήρες για την παροχή έξυπνων υπηρεσιών. Οι πόλεις συγκεντρώνουν μεγάλο ποσοστό του πληθυσμού και της ενέργειας, αλλά αντιμετωπίζουν την πρόκληση της διατήρησης μιας ισορροπημένης ανάπτυξης χωρίς περιβαλλοντικές επιπτώσεις. Με την ανάπτυξη των έξυπνων πόλεων παράγεται μεγάλος όγκος δεδομένων, τα οποία απαιτούν αποτελεσματική διαχείριση και υψηλό επίπεδο ασφάλειας για την προστασία της ιδιωτικής ζωής. Η συμμόρφωση με κανονισμούς, όπως ο Γενικός Κανονισμός Προσωπικών Δεδομένων, καθίσταται κρίσιμη για την προστασία του ανθρώπου, αποτρέποντας παραβιάσεις και κακόβουλες επιθέσεις. Η μελέτη αυτή στοχεύει να παρουσιάσει την έννοια των έξυπνων πόλεων, τις τεχνολογίες πληροφορικής και επικοινωνιών που ενσωματώνουν και τους κινδύνους που εγείρονται, με έμφαση στην προστασία και ασφάλεια των δεδομένων.
description: Technological progress affects all aspects of our lives, with the penetration of Information and Communication Technologies (ICT) being crucial in our personal, professional and social lives. An important area of this evolution is Smart Cities, which support sustainable development and improve the quality of life for residents by using connected devices and sensors to deliver smart services. Cities concentrate a large share of population and energy, but face the challenge of maintaining balanced growth without environmental impacts. The development of smart cities generates large volumes of data, which require effective management and a high level of security to protect privacy. Compliance with regulations, such as the General Data Protection Regulation, becomes critical to protect people, preventing breaches and malicious attacks. This study aims to introduce the concept of smart cities, the information and communication technologies they incorporate and the risks they pose, with a focus on data protection and security.
Using Portable Transducers to Measure Tremor Severity
Creators: name: Elble, Rodger J.
name: McNames, James
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Tremor
subject: Accelerometers
subject: Transducers
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Background: Portable motion transducers, suitable for measuring tremor, are now available at a reasonable cost. The use of these transducers requires knowledge of their limitations and data analysis. The purpose of this review is to provide a practical overview and example software for using portable motion transducers in the quantification of tremor.

Methods: Medline was searched via PubMed.gov in December 2015 using the Boolean expression “tremor AND (accelerometer OR accelerometry OR gyroscope OR inertial measurement unit OR digitizing tablet OR transducer).” Abstracts of 419 papers dating back to 1964 were reviewed for relevant portable transducers and methods of tremor analysis, and 105 papers written in English were reviewed in detail.

Results: Accelerometers, gyroscopes, and digitizing tablets are used most commonly, but few are sold for the purpose of measuring tremor. Consequently, most software for tremor analysis is developed by the user. Wearable transducers are capable of recording tremor continuously, in the absence of a clinician. Tremor amplitude, frequency, and occurrence (percentage of time with tremor) can be computed. Tremor amplitude and occurrence correlate strongly with clinical ratings of tremor severity.

Discussion: Transducers provide measurements of tremor amplitude that are objective, precise, and valid, but the precision and accuracy of transducers are mitigated by natural variability in tremor amplitude. This variability is so great that the minimum detectable change in amplitude, exceeding random variability, is comparable for scales and transducers. Research is needed to determine the feasibility of detecting smaller change using averaged data from continuous long-term recordings with wearable transducers.
Sicista concolor
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Zapodidae
Sicista
Sicista concolor

description: Sicista concolor (Buchner, 1892). Imp. Sci. St. Petersb., 35(3): 107. TYPE LOCALITY: China, Kansu, N. slope of the mountains of Sining, Guiduisha. DISTRIBUTION: Kansu, Tsinghai, and Szechwan (W. China); Kashmir. COMMENT: Corbet, 1978:149, included caucasica, caudata, and tianshanica in this species; also see Bobrinskii et al., 1965 [Key to the Mammals of the U.S. S. R.], Moscow; but also see Ellerman and Morrison-Scott, 1951:524 and Ognev, 1948, 6:32-45. OLR, AEM, and GSJ consider these forms distinct species. See also comments under caucasica, caudata, and tianshanica. ISIS NUMBER: 5301410015001004001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 563, DOI: 10.5281/zenodo.7353039
description: {"references": ["Bobrinskii, N. A., B. A. Kuznetsov, and A. P. Kuzyakin. 1965. Opredelitl' mlekopitayushchikh SSSR [Guide to the mammals of the U. S. S. R.] Second ed. Proveshchenie, Moscow, 382 pp. (in Russian).", "Ellerman, J. R., and T. C. S. Morrison-Scott. 1951. Checklist of Palaearctic and Indian mammals 1758 to 1946. Trustees of the British Museum (Natural History), London, 810 pp.", "Ognev, S. I. 1948. Zveri SSSR i prilezhashchikh stran: Gryzuny (prodolzhenie). (Zveri vostochnoi Evropy i severnoi Azii) [Mammals of the USSR and adjacent countries: Rodents (continued). (Mammals of eastern Europe and northern Asia)]. Akademiya Nauk SSSR, 6: 1 - 559 (in Russian)."]}
Electrically-Detected ESR in Silicon Nanostructures Inserted in Microcavities
Creators: name: Bagraev, Nikolay
name: Danilovskii, Eduard
name: Gehlhoff, Wolfgang
name: Gets, Dmitrii
name: Klyachkin, Leonid
name: Kudryavtsev, Andrey
name: Kuzmin, Roman
name: Malyarenko, Anna
name: Mashkov, Vladimir
name: Romanov, Vladimir
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present the first findings of the new electrically-detected electron spin resonance technique (EDESR), which reveal the point defects in the ultra-narrow silicon quantum wells (Si-QW) confined by the superconductor delta-barriers. This technique allows the ESR identification without application of an external cavity, as well as a high frequency source and recorder, and with measuring the only response of the magnetoresistance, with internal GHz Josephson emission within frameworks of the normal-mode coupling (NMC) caused by the microcavities embedded in the Si-QW plane.
title: Catalogus Librorum a Viro Plurimum Reuerendo Jo. Christiano Breuningio, Ecclesiæ Ratisbonensis Ministro, b. m. collectorum; [1778]
title: Jam vero Auctionis Lege A. MDCCLXXVIIII. d. XXII. Sept. & sqq. hora post meridiem IIda. In Aedibvs Pie Defvncti (in der Waffner-Strasse) publice divendendorum
titleType: Subtitle
Creators: name: Breuning, Johann Christian
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2016

description: Vorlageform des Erscheinungsvermerks: Ratisbonæ. - Druckvermerk: Auswärtige Bücherliebhaber können sich ... an den hiesigen Buchdrucker, Johann Christoph Keyser, wenden, bey welchem auch dieses Bücher-Verzeichniß unentgeldlich abgegeben wird.
The Sodium/Proline Transporter PutP of Helicobacter pylori
Creators: name: Rivera-Ordaz, Araceli
name: Bracher, Susanne
name: Sarrach, Sannia
name: Li, Zheng
name: Shi, Lei
name: Quick, Matthias
name: Hilger, Daniel
name: Haas, Rainer
name: Jung, Heinrich
Publisher: name: Columbia University
Year: 2013
Subjects: Proteins--Metabolism
Molecular structure
Helicobacter pylori
Molecular biology

description: Helicobacter pylori is cause of chronic gastritis, duodenal ulcer and gastric carcinoma in humans. L-proline is a preferred energy source of the microaerophilic bacterium. Previous analyses revealed that HpputP and HpputA, the genes that are predicted to play a central role in proline metabolism as they encode for the proline transporter and proline dehydrogenase, respectively, are essential for stomach colonization. Here, the molecular basis of proline transport in H. pylori by HpPutP was investigated experimentally for the first time. Measuring radiolabeled substrate transport in H. pylori and E. coli heterologously expressing HpputP as well as in proteoliposomes reconstituted with HpPutP, we demonstrate that the observed proline transport in H. pylori is mediated by HpPutP. HpPutP is specific and exhibits a high affinity for L-proline. Notably, L-proline transport is exclusively dependent on Na+ as coupling ion, i.e., Na+/L-proline symport, reminiscent to the properties of PutP of E. coli even though H. pylori lives in a more acidic environment. Homology model-based structural comparisons and substitution analyses identified amino acids crucial for function. HpPutP-catalyzed proline uptake was efficiently inhibited by the known proline analogs 3,4-dehydro-D,L-proline and L-azetidine-2-carboxylic acid.
Progressive Ataxia and Palatal Tremor: Think about POLG Mutations
Creators: name: Mongin, Marie
name: Delorme, Cecile
name: Lenglet, Timothee
name: Jardel, Claude
name: Vignal, Catherine
name: Roze, Emmanuel
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Ataxia
subject: Brain stem
subject: Eye--Paralysis
subject: Tremor
subject: Genetic disorders
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Background: Progressive ataxia and palatal tremor (PAPT) can be observed in both acquired brainstem or cerebellar lesions and genetic disorders.

Phenomenology shown: PAPT due to mutation in POLG, the gene encoding the mitochondrial DNA polymerase.

Educational value: POLG mutation should be considered in patients with PAPT, particularly when additional clues such as a sensory neuronopathy or an ophthalmoplegia are present.
Urinary and Dietary Analysis of 18,470 Bangladeshis Reveal a Correlation of Rice Consumption with Arsenic Exposure and Toxicity
Creators: name: Melkonian, Stephanie
name: Argos, Maria
name: Hall, Megan N.
name: Chen, Yu
name: Parvez, Faruque
name: Pierce, Brandon
name: Cao, Hongyuan
name: Aschebrook-Kilfoy, Briseis
name: Ahmed, Alauddin
name: Islam, Tariqul
name: Slavcovich, Vesna
name: Gamble, Mary
name: Haris, Parvez I.
name: Graziano, Joseph H.
name: Ahsan, Habibul
Publisher: name: Columbia University
Year: 2013
Subjects: Rice
Arsenic
Arsenic--Toxicology
Public health
Environmental health

description: Background: We utilized data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, to evaluate the association of steamed rice consumption with urinary total arsenic concentration and arsenical skin lesions in the overall study cohort (N=18,470) and in a subset with available urinary arsenic metabolite data (N=4,517).

Methods: General linear models with standardized beta coefficients were used to estimate associations between steamed rice consumption and urinary total arsenic concentration and urinary arsenic metabolites. Logistic regression models were used to estimate prevalence odds ratios (ORs) and their 95% confidence intervals (CIs) for the associations between rice intake and prevalent skin lesions at baseline. Discrete time hazard models were used to estimate discrete time (HRs) ratios and their 95% CIs for the associations between rice intake and incident skin lesions.

Results: Steamed rice consumption was positively associated with creatinine-adjusted urinary total arsenic (β=0.041, 95% CI: 0.032-0.051) and urinary total arsenic with statistical adjustment for creatinine in the model (β=0.043, 95% CI: 0.032-0.053). Additionally, we observed a significant trend in skin lesion prevalence (P-trend=0.007) and a moderate trend in skin lesion incidence (P-trend=0.07) associated with increased intake of steamed rice.

Conclusions: This study suggests that rice intake may be a source of arsenic exposure beyond drinking water.
"Credit and Worthiness": Forming and Organizing Subjects in the Credit Economy
Creators: name: Fletcher, Arahi
Publisher: name: University of Chicago
Year: 2023
Subjects: subject: creditworthiness
subject: subject formation
subject: political economy of credit
subject: debt relation
subject: stretched marxism

description: "Creditworthiness" is a knowledge object central to the establishment of a leveraged economy over the last century, that has nevertheless gone relatively unexamined. In this thesis, I assert that “creditworthiness” is a conceptual knowledge object around which subjects unique to the consumption economy are formed. In support of this theoretical framework, I offer two case studies: 1) the establishment of creditworthiness through the FHA based on racial underwriting, subsequent “block-busting” practices, and the Community Reinvestment Act, and 2) the Fringe Economy of Alternative Financial Services today. These histories and ongoing dynamics reveal "creditworthiness" as a constructed knowledge intersecting with and mirroring race as a discursive market technology. I argue that "creditworthiness" is used to form market subjects from which wealth is systemically siphoned, a practice necessary to the credit-based economy at large.
Coherence effects between the initial and final state radiation in a dense QCD medium
Creators: name: Martinez, Mauricio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In these proceedings contribution we review our recent results of medium modifications to the coherence pattern between the initial and final state radiation. We study single gluon production off a highly energetic parton that undergoes a hard scattering and subsequently crosses a dense QCD medium of finite size. Multiple scatterings lead to a partial suppression of the interferences between different emitters that opens the phase space for large angle emissions. We briefly discuss the generalization of this setup to describe gluon production in the case of pA collisions by including finite length and energy corrections. The configuration studied here may have phenomenological consequences in high-energy nuclear collisions.
description: 8 pages, 1 figure. Plenary contribution to the IS2013 Conference, September 8-14 2013, Illa da Toxa - Galicia (Spain). Matched with the published version
Learning curve for collective behavior of zero-intelligence agents in successive job-hunting processes with a diversity of Jaynes-Shannon's MaxEnt principle
Creators: name: Chen, He
name: Inoue, Jun-ichi
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Finance (q-fin.GN)
subject: FOS: Economics and business

description: Inspired by the unsupervised learning or self-organization in the machine learning context, here we attempt to draw `learning curve' for the collective behavior of job-seeking `zero-intelligence' labors in successive job-hunting processes. Our labor market is supposed to be opened especially for university graduates in Japan, where the students have several successive chances n=0,1,2,... to obtain their positions within an academic (business) year. In this sense, the `cumulative unemployment rate' in our model system is regarded as an error-measurement in the collective intelligence of students, and the job-hunting stage n-dependence of the error constructs a learning curve. In our simple toy-model of probabilistic labor market, the diversity of students' behavior is built-in by means of the Jaynes-Shannon's MaxEnt (Maximum Entropy) principle. Then, we discuss the speed of convergence for the error-measurement, where we consider a scenario in which the students do not use any information about the result of job-hunting processes in the previous stage. Our approach enables us to examine the existence of the condition on which macroscopic quantity, say, `stage-wise unemployment rate' becomes `scale-invariant' in the sense that it does not depend on the job-hunting stage n. From the macroscopic view point, the problem could be regarded as a human resource allocation.
description: 18 pages, 9 figures
Post-mortem Findings in Huntington's Deep Brain Stimulation: A Moving Target Due to Atrophy
Creators: name: Vedam-Mai, Vinata
name: Martinez-Ramirez, Daniel
name: Hillard, Justin D.
name: Carbunaru, Samuel
name: Yachnis, Anthony T.
name: Bloom, Joshua
name: Keeling, Peyton
name: Awe, Lisa
name: Foote, Kelly D.
name: Okun, Michael S.
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Brain stimulation
subject: Huntington's disease
subject: Muscular atrophy
subject: Chorea
subject: Histology, Pathological
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD).

Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized.

Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.
The Most Cited Works in Essential Tremor and Dystonia
Creators: name: King, Nicolas K. K.
name: Tam, Joseph
name: Fasano, Alfonso
name: Lozano, Andres M.
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Tremor
subject: Dystonia
subject: Movement disorders
subject: Medicine

description: Background: The study of the most cited works in a particular field gives an indication of the important advances, developments, and discoveries that have had the highest impact in that discipline. Our aim was to identify the most cited works in essential tremor (ET) and dystonia.

Methods: A bibliometric search was performed using the ISI Web of Science database using selected search terms for ET and dystonia for articles published from 1900 to 2015. The resulting citation counts were analyzed to identify the most cited works, and the studies were categorized.

Results: Using the criterion of more than 400 citations, there were four citation classics for ET and six for dystonia. The most cited studies were those on pathophysiology followed by medical treatments, clinical classification, genetic studies, surgical treatments, review articles, and epidemiology studies. A comparison of the most cited articles for ET and dystonia showed that there was a divergence, with ET and dystonia having a higher number of epidemiologic and genetic studies, respectively. Whereas the peak period for the number of publications was 2000–2004 for ET, it was 1995–1999 for dystonia.

Discussion: Given the large number of patients with these disorders, there appears to be an unmet need for further research advances in both areas, but particularly for ET as the most common movement disorder.
Moving Objects in the Hubble Ultra Deep Field
Creators: name: Kilic, Mukremin
name: Gianninas, Alexandros
name: von Hippel, Ted
Publisher: name: arXiv
Year: 2013
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We identify proper motion objects in the Hubble Ultra Deep Field (UDF) using the optical data from the original UDF program in 2004 and the near-infrared data from the 128-orbit UDF 2012 campaign. There are 12 sources brighter than I=27 mag that display >3sigma significant proper motions. We do not find any proper motion objects fainter than this magnitude limit. Combining optical and near-infrared photometry, we model the spectral energy distribution of each point-source using stellar templates and state-of-the-art white dwarf models. For I<27 mag, we identify 23 stars with K0-M6 spectral types and two faint blue objects that are clearly old, thick disk white dwarfs. We measure a thick disk white dwarf space density of 0.1-1.7 E-3 per cubic parsec from these two objects. There are no halo white dwarfs in the UDF down to I=27 mag. Combining the Hubble Deep Field North, South, and the UDF data, we do not see any evidence for dark matter in the form of faint halo white dwarfs, and the observed population of white dwarfs can be explained with the standard Galactic models.
description: ApJ, in press
Genetic Polymorphisms of XRCC1 and Leukemia Risk: A Meta-Analysis of 19 Case-Control Studies
Creators: name: Zhang, Haijun
name: Liu, Hang
name: Jiang, Gaofeng
Publisher: name: Columbia University
Year: 2013
Subjects: Meta-analysis
Genetic polymorphisms
Leukemia
Genomics

description: Objective

Three common X-ray repair cross-complementing groups 1 (XRCC1) polymorphisms, Arg399Gln, Arg194Trp, and Arg280His, have been reported to be implicated in the development of leukemia. However, previous results from different studies were inconsistent. Consequently, we performed a meta-analysis in order to accurately evaluate the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and leukemia risk.

Methods

Through computerized searching of PubMed, ISI Web of Knowledge, Cochrane, EBSCO, and OpenGrey databases, and manually searching relevant references, a total of 19 studies with 3387 cases and 6168 controls for Arg399Gln (G>A) polymorphism, 12 studies with 2043 cases and 4550 controls for Arg194Trp (C>T), and 6 studies with 1445 cases and 1905 controls for Arg280His (G>A) were collected to perform meta-analysis and stratified analysis to explore the associations between these variants and leukemia susceptibility. Based on three genetic models, the codominant model, dominant model and recessive model, odds ratios (ORs) as well as their 95% confidence intervals (CIs) were used to evaluate the association strength between XRCC1 genotypes and leukemia risk.

Results

With respect to overall leukemia susceptibility, no association was detected. In stratified analyses by tumor type, Arg399Gln was associated with higher acute lymphoblastic leukemia (ALL) risk (AA vs. GG, OR  =  1.50, 95% CI: 1.11-2.02; AA+GA vs. GG, OR  =  1.35, 95% CI: 1.02-1.78). Additionally, Arg399Gln, Arg194Trp, and Arg280His may influence the susceptibilities of some leukemia type and race populations.

Conclusion

This meta-analysis indicates these three polymorphisms of XRCC1 do not associate with overall leukemia risks but could be associated with the risks for some specific subgroups.
title: Investigating the impact of, novel, therapeutic delivery systems on immunological responses - determination of short, and long-term, exposure effects
Creators: name: Brain, Danielle
Publisher: name: University of Liverpool Repository
Year: 2023

description: Long-acting therapeutics are being explored for their use in improving adherence to medication and enhancing overall treatment outcomes. Due to increased residence time at the site of administration e.g., subcutaneous, long-acting formulations may affect the responses of local immune cells, due to modifications in the long-acting formulations to improve administration and allow the drugs to be released over specific time periods. Therefore, adaptation of current safety assessments must be considered, to safely translate these formulations into clinical studies. Long-acting formulations of the Nucleotide Reverse Transcriptase Inhibitors (NRTIs): FTC, 3TC and TAF were developed for subcutaneous administration for the treatment of HIV, hereafter termed Polymer of Prodrug (POP) formulations. This thesis starts to explore the immunocompatibility of these POP formulations and their interactions with cells and components of the immune system. Complement analysis showed concentration dependent activation from the linear poly(FTC) formulation. Impact of repeated exposure of the NRTI drugs FTC, 3TC and the POP formulation linear poly(FTC) to cell lines was explored, responses were cell line and drug specific, the linear poly(FTC) formulation was only tested in the MUTZ-3 cell line and led to particularly interesting significant changes in marker expression. In vivo analysis of three FTC containing POP polymers were assessed for cytokine perturbations alongside the pharmacokinetic analysis, no significant perturbations were seen across the board for any of the three implants tested. Early analysis of TAF carbamate pro drugs was carried out to determine whether they could alter cell health and cytotoxicity, no significant perturbations were seen, suggesting that POP implants made from these prodrugs may be safe. The model systems used and developed in this thesis will help to characterise and assess the immunocompatibility of long-acting formulations in the future, particularly those administered subcutaneously.
Sicista kluchorica Sokolov, Kovalskaya, and Baskevich 1980
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Zapodidae
Sicista
Sicista kluchorica

description: Sicista kluchorica Sokolov, Kovalskaya, and Baskevich, 1980. Gryzuny Severnovo Kavkaza., p. 38. TYPE LOCALITY: U.S. S. R., Georgian S.S. R., Tebardin Zapovednik, Upper Severnyi Klukhor River. DISTRIBUTION: Known only from the type locality. COMMENT: See Sokolov et al., 1980:38, and Sokolov, et al., 1981, Zool. Zh., 60(9): 1391, for evidence of specific distinctness.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 564, DOI: 10.5281/zenodo.7353039
Two stream instabilities in degenerate quantum plasmas
Creators: name: Son, S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The quantum mechanical effect on the plasma two-stream instability is studied based on the dielectric function approach. The analysis suggests that the degenerate plasma relevant to the inertial confinement fusion behaves differently from classical plasmas when the electron drift velocity is comparable to the Fermi velocity. For high wave vector comparable to the Fermi wave vector, the degenerate quantum plasma has larger regime of the two-stream instabilities than the classical plasma. A regime, where the plasma waves with the frequency larger than 1.5 times of the Langmuir wave frequency become unstable to the two-stream instabilities, is identified.
Sicista napaea Hollister 1912
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Zapodidae
Sicista
Sicista napaea

description: Sicista napaea Hollister, 1912. Smithson. Misc. Coll., 60(14):2. TYPE LOCALITY: U.S. S. R., Altaisk. Krai, Altai Mtns., Seminsk Ridge, about 5 mi. (8 km) S. of Tapuchii. DISTRIBUTION: N.W. Altai Mtns. (U.S. S.R.). ISIS NUMBER: 5301410015001005001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 564, DOI: 10.5281/zenodo.7353039
Ipsilateral Hemichorea-hemiballism in a Case of Postoperative Stroke
Creators: name: Kannepalli, Narasinga Rao V. L.
name: Yadav, Ravi
name: Vazhayil, Vikas
name: Somanna, Sampath
name: Pal, Pramod Kumar
Publisher: name: Columbia University
Year: 2016
Subjects: subject: Cerebrovascular disease
subject: Cerebrovascular disease--Surgery
subject: Basal ganglia
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Background: Ipsilateral hemiballismus refers to the rare occurrence of hemiballism developing on the same side of a brain lesion.

Case report: We describe a rare case of postoperative ipsilateral hemiballism in a patient who underwent pituitary adenoma resection and experienced a right internal cerebral artery territory infarct. We review the literature on hemichorea hemiballismus (HCHB) and explore various mechanisms for its occurrence.

Discussion: Only three cases of ipsilateral hemiballism have been described, and the exact pathophysiology remains unknown. A dominant left hemisphere with corpus callosal connections to the right basal ganglia is the most probable explanation for this unusual event.
Prospects for electron spin-dependent short-range force experiments with rare earth iron garnet test masses
Creators: name: Leslie, T. M.
name: Weisman, E.
name: Khatiwada, R.
name: Long, J. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A study of the possible interactions between fermions assuming only rotational invariance has revealed 15 forms for the potential involving the fermion spins. We review the experimental constraints on unobserved macroscopic, spin-dependent interactions between electrons in the range below 1 cm. An existing experiment, using 1 kHz mechanical oscillators as test masses, has been used to constrain mass-coupled forces in this range. With suitable modifications, including spin-polarized test masses, this experiment can be used to explore all 15 possible spin-dependent interactions between electrons in this range with unprecedented sensitivity. Samples of ferrimagnetic dysprosium iron garnet have been fabricated in the suitable test mass geometry and shown to have high spin density with very low intrinsic magnetism.
description: 13 pages, 6 figures, REVTeX 4.1, new title, additional authors, now with experimental results on polarized test masses
title: Catalogvs Bibliothecae B. Christiani Ernesti A Windheim In Academia Erlangensi Olim LL. Orient. Et Philos. Professoris; 1767
title: D. XIII. Febr. A. MDCCLXVIII. Erlangae Auctionis Lege Divendendae
titleType: Subtitle
Creators: name: Windheim, Christian Ernst ¬von
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2016

description: Vorlageform des Erscheinungsvermerks: Erlangae MDCCLXVII. Typis Tetschnerianis
Sicista pseudonapaea Strautman 1949
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Zapodidae
Sicista
Sicista pseudonapaea

description: Sicista pseudonapaea Strautman, 1949. Vestn. Akad. Nauk Kazakh. S.S.R., 5:109. TYPE LOCALITY: U.S. S. R., E. Kazakhstan, Altai Mtns., N. slope of Narym Range, Katon-Karagai. DISTRIBUTION: Taiga of Altai Mtns. (U.S. S. R.); probably W. China and N.W. Mongolia. COMMENT: Bobrinskii et al., 1965 [Key to the Mammals of the U.S. S. R.], Moscow, and Sokolov et al., 1980:38, considered this species distinct, but see Gromov et al., 1963, [Mammal Fauna of the U.S. S. R.], Moscow, 2 vols., and Gromov and Baranova, 1981:111, who included pseudonapaea in betulina.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 564, DOI: 10.5281/zenodo.7353039
description: {"references": ["Bobrinskii, N. A., B. A. Kuznetsov, and A. P. Kuzyakin. 1965. Opredelitl' mlekopitayushchikh SSSR [Guide to the mammals of the U. S. S. R.] Second ed. Proveshchenie, Moscow, 382 pp. (in Russian).", "Gromov, I. M., A. A. Gureev, G. A. Novikov, I. I. Sokolov, P. P. Strelkov, and K. K. Chapskii. 1963. Mlekopitayushchie fauny SSSR, Chast' 1. [Mammals of the fauna of the USSR. [Vol.] 1. Insectivora, Chiroptera, Lagomorpha, and Rodentia]. Akademii Nauk SSSR, Moskva, 1: 1 - 640.", "Gromov, I. M., and G. I. Baranova (eds.). 1981. Katalog mlekopitayushchikh SSSR [Catalog of mammals of the USSR]. Nauka, Leningrad, 456 pp. (in Russian)."]}
Development of Methods for Cross-Sectional HIV Incidence Estimation in a Large, Community Randomized Trial
Creators: name: Laeyendecker, Oliver
name: Kulich, Michal
name: Donnell, Deborah
name: Komárek, Arnošt
name: Omelka, Marek
name: Mullis, Caroline E.
name: Piwowar-Manning, Estelle
name: Szekeres, Greg
name: Fiamma, Agnes
name: Gray, Ronald H.
name: Lutalo, Tom
name: Morrison, Charles S.
name: Salata, Robert A.
name: Chipato, Tsungai
name: Celum, Connie
name: Taha, Taha E.
name: Kahle, Erin M.
name: Kumwenda, Newton I.
name: Karim, Quarraisha Abdool
name: Naranbhai, Vivek
name: Lingappa, Jairam R.
name: Sweat, Michael D.
name: Coates, Thomas
name: Eshleman, Susan H.
Publisher: name: Columbia University
Year: 2013
Subjects: Algorithms
Serology
HIV infections--Epidemiology
Public health

description: Background

Accurate methods of HIV incidence determination are critically needed to monitor the epidemic and determine the population level impact of prevention trials. One such trial, Project Accept, a Phase III, community-randomized trial, evaluated the impact of enhanced, community-based voluntary counseling and testing on population-level HIV incidence. The primary endpoint of the trial was based on a single, cross-sectional, post-intervention HIV incidence assessment.

Methods and Findings

Test performance of HIV incidence determination was evaluated for 403 multi-assay algorithms [MAAs] that included the BED capture immunoassay [BED-CEIA] alone, an avidity assay alone, and combinations of these assays at different cutoff values with and without CD4 and viral load testing on samples from seven African cohorts (5,325 samples from 3,436 individuals with known duration of HIV infection [1 month to >10 years]). The mean window period (average time individuals appear positive for a given algorithm) and performance in estimating an incidence estimate (in terms of bias and variance) of these MAAs were evaluated in three simulated epidemic scenarios (stable, emerging and waning). The power of different test methods to detect a 35% reduction in incidence in the matched communities of Project Accept was also assessed. A MAA was identified that included BED-CEIA, the avidity assay, CD4 cell count, and viral load that had a window period of 259 days, accurately estimated HIV incidence in all three epidemic settings and provided sufficient power to detect an intervention effect in Project Accept.

Conclusions

In a Southern African setting, HIV incidence estimates and intervention effects can be accurately estimated from cross-sectional surveys using a MAA. The improved accuracy in cross-sectional incidence testing that a MAA provides is a powerful tool for HIV surveillance and program evaluation.
The Effect of Dipole Boron Centers on the Electroluminescence of Nanoscale Silicon p+-n Junctions
Creators: name: Bagraev, Nikolay
name: Klyachkin, Leonid
name: Kuzmin, Roman
name: Malyarenko, Anna
name: Mashkov, Vladimir
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Nanoscale silicon p(+)-n junctions with very high concentration of boron, 5 10^21 cm-3, are found to demonstrate interesting optical properties. Emission band dominated in near-infrared electroluminescence (EL) spectra possesses high degree of the linear polarization along preferred crystallographic axis which can be controlled by the lateral voltage applied in the plane of the p(+)-n junction. Such behavior together with the temperature dependence of the EL intensity is attributed to the presence of the self-compensating dipole boron centers, B(+)-B(-), with negative correlation energy which are identified using the ESR technique in the nanoscale silicon p(+)-n junctions heavily doped with boron. The model of the recombination process though the negative-U dipole boron centers controlling the optical properties of the nanoscale silicon p(+)-n junctions is proposed.
Substantial Conformational Change Mediated by Charge-Triad Residues of the Death Effector Domain in Protein-Protein Interactions
Creators: name: Twomey, Edward Charles
name: Cordasco, Dana F.
name: Kozuch, Stephen D.
name: Wei, Yufeng
Publisher: name: Columbia University
Year: 2013
Subjects: Nuclear magnetic resonance
Phosphoproteins
Proteins--Conformation
Cytology

description: Protein conformational changes are commonly associated with the formation of protein complexes. The non-catalytic death effector domains (DEDs) mediate protein-protein interactions in a variety of cellular processes, including apoptosis, proliferation and migration, and glucose metabolism. Here, using NMR residual dipolar coupling (RDC) data, we report a conformational change in the DED of the phosphoprotein enriched in astrocytes, 15 kDa (PEA-15) protein in the complex with a mitogen-activated protein (MAP) kinase, extracellular regulated kinase 2 (ERK2), which is essential in regulating ERK2 cellular distribution and function in cell proliferation and migration. The most significant conformational change in PEA-15 happens at helices α2, α3, and α4, which also possess the highest flexibility among the six-helix bundle of the DED. This crucial conformational change is modulated by the D/E-RxDL charge-triad motif, one of the prominent structural features of DEDs, together with a number of other electrostatic and hydrogen bonding interactions on the protein surface. Charge-triad motif promotes the optimal orientation of key residues and expands the binding interface to accommodate protein-protein interactions. However, the charge-triad residues are not directly involved in the binding interface between PEA-15 and ERK2.
Clinical and Socio-Demographic Characteristics of College Students Exposed to Traumatic Experiences: A Census of Seven College Institutions in Northeastern Brazil
Creators: name: Netto, Liana R.
name: Cavalcanti-Ribeiro, Patrícia
name: Pereira, Juliana L.
name: Nogueira, José F.
name: Santos, Lene L.
name: Lira, Sidnei B.
name: Guedes, Gisela M.
name: Teles, Carlos A.
name: Koenen, Karestan C.
name: Quarantini, Lucas C.
name: The Trauma, Anxiety Disorders Study Group (TADSG) -. UFBA
Publisher: name: Columbia University
Year: 2013
Subjects: Families
Educational attainment
Post-traumatic stress disorder
Public health

description: Background

Epidemiological studies show that most of the adult population will be exposed to at least one potentially traumatic event in the course of his/her life; adolescence and early adulthood are the most vulnerable periods of life for exposure to traumatic experiences (70% of their deaths are due to external causes). Posttraumatic Stress Disorder is characterized by the development of dysfunctional symptoms that cause distress or social, academic, or occupational impairment, as result of exposure to a traumatic event. The aim of this multicentric study is to establish the proportion of college students, within seven institutions in Northeastern Brazil, who were exposed to traumatic experience and met PTSD criteria.

Methods/Design

A one-phase census protocol of seven college institutions in three metropolitan regions in Northeastern Brazil was performed (April to July 2011). All students aged 18 years or older, matriculated and attending their first or final semester were eligible. The self-applied protocol consisted of a socio-demographic questionnaire and the following scales adjusted to Brazilian Portuguese standards Trauma History Questionnaire (THQ), PTSD Checklist-Civilian (PCL-C), Impulsivity Scale (BIS-11). Data were entered into SPSS 17.0.

Results

2213 (85.5%) students consented to participate, and completely filled in the protocols. Of these, 66.1% were woman, mean age 23.9 (SD 6.3), 82.7% were single, and 57.3% attended university outside their native cities. The total PTSD prevalence was 14%, and the median for frequency of trauma exposure was 5 events.

Conclusion

A high frequency of exposure to violence, as well as a high rate of PTSD, suicide attempts, and high-risk sexual behavior was found in Brazilian college students. This highlights the importance of effective public health actions in relation to the prevention and treatment of PTSD and other dysfunctional behaviors resulting from traumatic exposure in young individuals, usually an at risk population for violence and traumatic situations.