cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Jurisdictional Intersection: Family Law And The Equity Doctrine
Creators: name: Wilson, Joshua Douglas
Publisher: name: Swinburne
Year: 2024

description: Principles governing the alteration of property interests under the Family Law Act have their sources deeply embedded in the equity doctrine. Curiously, over the four and a half decades of the operation of the Family Law Act, no detailed examination has been given to the jurisdictional intersection between the two bodies of legal jurisprudence. This thesis, the first exposition of its kind in Australia and written by a sitting Justice of the Family Court of Australia, (now Division One of the Federal Circuit and Family Court of Australia), explores the metes and bounds of that jurisdictional intersection and is of immediate utility to legal practitioners, legal historians and students alike.
Effect of Fungal Deterioration on Physical and Mechanical Properties of Hemp and Flax Natural Fiber Composites
Creators: name: Crawford, Bryn
name: Pakpour, Sepideh
name: Kazemian, Negin
name: Klironomos, John
name: Stoeffler, Karen
name: Rho, Denis
name: Denault, Johanne
name: Milani, Abbas S.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The development and application of bio-sourced composites have been gaining wide attention, yet their deterioration due to the growth of ubiquitous microorganisms during storage/manufacturing/in-service phases is still not fully understood for optimum material selection and design purposes. In this study, samples of non-woven flax fibers, hemp fibers, and mats made of co-mingled randomly-oriented flax or hemp fiber (50%) and polypropylene fiber (50%) were subjected to 28 days of exposure to (i) no water-no fungi, (ii) water only and (iii) water along with the Chaetomium globosum fungus. Biocomposite samples were measured for weight loss over time, to observe the rate of fungal growth and the respiration of cellulose components in the fibers. Tensile testing was conducted to measure mechanical properties of the composite samples under different configurations. Scanning electron microscopy was employed to visualize fungal hyphal growth on the natural fibers, as well as to observe the fracture planes and failure modes of the biocomposite samples. Results showed that fungal growth significantly affects the dry mass as well as the tensile elastic modulus of the tested natural fiber mats and composites, and the effect depends on both the type and the length scale of fibers, as well as the exposure condition and time.
3362656.pdf
Creators: name: McNeur, Joshua
name: Kozák, Martin
name: Schönenberger, Norbert
name: Leedle, Kenneth
name: Deng, Huiyang
name: Ceballos, Andrew
name: Hoogland, Heinar
name: Ruehl, Axel
name: Hartl, Ingmar
name: Holzwarth, Ronald
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Updated Supplementary Text file with modified Figure S1
Common trunk between V1 + 2 and V3 of the left superior pulmonary vein
Creators: name: Amore, Dario
name: Casazza, Dino
name: Imitazione, Pasquale
name: Caterino, Umberto
name: Cagini, Lucio
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Common trunk between V1 + 2 and V3 of the left superior pulmonary vein
Set-indexed survival analysis with generalized censoring
Creators: name: Aguirre, Alberto Carabarin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Mathematics.

description: This thesis focuses on the problem of survival analysis of data subject to generalized censoring by an arbitrary adapted random set. We consider the problem of estimation of both the cumulative hazard and the distribution function. A problem with observability of certain events needed to construct the Nelson-Aalen estimator for the cumulative hazard is resolved by introducing a new model based on a more general type of random set. Under the framework of this censoring scheme, we reconstruct the Nelson-Aalen estimator and propose three different estimators for the distribution function: the first two come from a reverse probability equation and the last is a path-dependent estimator. Functional central limit theorems are proven for each of these estimators which, coupled with bootstrapping methods, allow us to explore some applications, like tests for independence of the components in the bivariate case, a test of hazard rate order and copula estimation. The novelty of this work is twofold: first, the techniques developed may be applied not only to distributions on Euclidean spaces, but also to distributions on more general metric spaces, and second, the generalized censoring mechanism subsumes and extends the usual models used in multivariate survival analyis.
title: Dietary Intake of Flavonoids and Ventilatory Function in European Adults
title: A GA2LEN Study
titleType: Subtitle
Creators: name: Garcia-Larsen, Vanessa
name: Thawer, Narjis
name: Charles, David
name: Cassidy, Aedin
name: Van Zele, Thibaut
name: Thilsing, Trine
name: Ahlstrom, Matti
name: Haahtela, Tari
name: Keil, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: flavonoids
subject: pro-anthocyanidins
subject: lung function
subject: GA2LEN
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro- anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults. View Full-Text
From Reflective Practitioner to Learning Professionals: The role of reflecting and learning in architectural teams
Creators: name: Tan, Linus
Publisher: name: Swinburne
Year: 2024

description: To work effectively as a team, architects must not only reflect on their individual experience, but also learn from each other. This thesis investigated both processes – reflecting and learning – through three research studies. The first study examined six design teams’ reflective practices and team learning qualities when they pitched for an architectural project valued at $2 billion. The second study surveyed 105 architects and revealed distinct team learning behaviours that were linked closely to team effectiveness. The last study tested a one-hour online workshop with an architecture firm to reflect on and learn from their team processes, which resulted in gradual improvements in their team performance.
Study of the production of fructose and ethanol from sucrose and molasses media using Saccharomyces cerevisiae ATCC 36858
Creators: name: Atiyeh, Hasan K
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Biology, Microbiology.
subject: Engineering, Chemical.

description: Fructose is available as a component of invert sugar and of high fructose corn syrups (HFCS) in which fructose and glucose are present in nearly equimolar concentrations. This study reports on a new mutant, Saccharomyces cerevisiae ATCC 36858, which is able to produce enriched and pure fructose syrups from synthetic glucose/fructose mixtures, sucrose and raffinose, and from molasses media. In this study, the results showed that S. cerevisiae ATCC 36858 can hydrolyze sucrose, raffinose and melibiose then selectively ferment glucose and galactose to ethanol. In batch tests, the fructose yield was above 93% of the theoretical value in synthetic glucose/fructose media with a total sugar concentration of 300 g/L. The ethanol yield was about 76% of the theoretical value. The fructose yield was above 90% of the theoretical value in synthetic media with a sucrose concentration up to 726 g/L and in molasses media with a sugar concentration up to 323 g/L. The ethanol yield was between 72 and 85% in synthetic media with a sucrose concentration up to 451 g/L. A lower ethanol yield was obtained in molasses media. The strain of yeast used can be considered osmophilic because it can grow in synthetic media even with a sucrose concentration above 530 g/L. In synthetic media with initial raffinose concentrations between 30 and 242 g/L, fructose and ethanol yields were between 82 and 96%, and 67 and 76%, respectively. Syrups with more than 97% fructose based on the final total sugar concentrations can be produced from synthetic media with initial sucrose concentrations below 360 g/L. Even at a sucrose concentration of 574 g/L, the produced syrup contained 59% fructose and thus, it was richer in this carbohydrate than the ordinary 55% HFCS. The fructose fractions in the carbohydrate content of the produced syrups was more than 95% when the total initial sugar concentrations in sugar cane and beet molasses media were below 274 and 242 g/L, respectively. Syrups with more than 96% fructose based on the final total sugar concentrations can be produced in media with initial raffinose concentrations below 189 g/L. The effects of initial biomass, yeast extract and ethanol concentrations, pH, and media sterilization on the production of fructose and ethanol in synthetic sucrose media were also examined. (Abstract shortened by UMI.)
A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-kB
Creators: name: Freise, Christian
name: Kim, Ki Young
name: Querfeld, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Vascular calcifications bear the risk for cardiovascular complications and have a high prevalence among patients with chronic kidney disease. Central mediators of vascular calcifications are vascular smooth muscle cells (VSMC). They transdifferentiate into a synthetic/osteoblast-like phenotype, which is induced, for example, by elevated levels of calcium and phosphate (Ca/P) due to a disturbed mineral balance. An aqueous extract from Lindera obtusiloba (LOE) is known to exert antifibrotic and antitumor effects or to interfere with the differentiation of preadipocytes. Using murine and rat VSMC cell lines, we here investigated whether LOE also protects VSMC from Ca/P-induced calcification. Indeed, LOE effectively blocked Ca/P-induced calcification of VSMC as shown by decreased VSMC mineralization and secretion of alkaline phosphatase. In parallel, mRNA expression of the calcification markers osterix and osteocalcin was reduced. Vice versa, the Ca/P-induced loss of the VSMC differentiation markers alpha smooth muscle actin and smooth muscle protein 22-alpha was rescued by LOE. Further, LOE blocked Ca/P-induced mRNA expressions and secretions of matrix metalloproteinases-2/-9 and activation of NF-B, which are known contributors to vascular calcification. In conclusion, LOE interferes with the Ca/P-induced transdifferentiation/calcification of VSMC. Thus, LOE should be further analysed regarding a potential complementary treatment option for cardiovascular diseases including vascular calcifications.
Distribution and power of selected item bias indices: A Monte Carlo study.
Creators: name: Ibrahim, Abdul K.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Education, Tests and Measurements.

description: This study examines the following DIF procedures--Transformed Item Difficulty (TID), Full Chi-Square, Mantel-Haenszel chi-square, Mantel-Haenszel delta, Logistic Regression, SOS2, SOS4, and Lord's chi-square under three sample sizes, two test lengths, four cases of item discrimination arrangement, and three item difficulty levels. The study is in two parts: The first part examines the distributions of the indices under null (no bias) conditions. The second part deals with the power of the procedures to detect known bias in simulated test data. Agreements among procedures are also addressed. Lord's chi-square certainly appears to perform very well. Its detection rates were very good, and its percentiles were not affected by discrimination level or test length. In retrospect, one would like to know how well it might do at smaller sample sizes. When the tabled values were used, it performed equally well in detecting bias and improved in reducing false positive rates. Of the other indices, the Mantel-Haenszel and the logistic regression indices seemed the best. Camilli chi-square had a number of problems. Its tabled values were not at all useful for detection of bias. The TID was somewhat better but does not have a significance test associated with it. One would need to rely on baseline studies, if one were to use it. For uniform bias either Mantel-Haenszel chi-square or logistic regression would be recommended, while for nonuniform bias logistic regression would be appropriate. It is interesting to note that Lord's chi-square was effective for detecting either kinds of bias. We have been told that sample size is related to chi-square values. For each of the chi square indices the observed values were considerably lower than tabled values. Of course, these were conditions where no bias was present except that which might be randomly induced in data generation. Perhaps it is those instances where bias is truly present that larger sample sizes allow us to more easily identify biased items. Certainly the proportions of biased items detected was greater for large sample sizes for Camilli chi-square, Mantel-Haenszel chi-square, and logistic regression chi-squares.
Development of tools to prevent food waste
Creators: name: Jepsen, Dirk
name: Vollmer, Annette
name: Eberle, Ulrike
Publisher: name: My University
Year: 2016
Subjects: subject: Nahrungsmittelabfall
subject: Abfallvermeidung
subject: Food losses
subject: waste prevention
subject: environmental impacts
subject: Life Cycle Assessment
subject: legal
subject: Waste | Resources

description: I
description: Food losses and food waste along the food value chain are a central problem not only for moral and ethical reasons, but also from an environmental perspective. The production and processing of food entail serious environmental impacts which could be reduced significantly by lowering food loss rates. Reducing food losses and food waste may as well contribute significantly to climate and to resource protection as the study underlines.
Rainwater harvesting system with the perspective of its water saving potentials, reliability, and cost efficiency: a case study for Adelaide
Creators: name: Paudel, Upendra
Publisher: name: Swinburne
Year: 2024

description: Rainwater is a very popular alternative water resource in Adelaide, South Australia. In Adelaide, fewer studies have been done regarding optimal sizing of rainwater tanks for the specific site conditions. This research will provide in depth understanding on water saving efficiency, reliability and cost effectiveness of the rainwater harvesting system so that user can select the proper tank even in the critical dry period. Also, outcome of this research will be helpful for government authorities in managing current and future water demand as well as justifiable disbursement of government incentives for the promotion of rainwater harvesting system in the community.
Nesfatin-130−59 Injected Intracerebroventricularly Differentially Affects Food Intake Microstructure in Rats Under Normal Weight and Diet-Induced Obese Conditions
Creators: name: Prinz, Philip
name: Teuffel, Pauline
name: Lembke, Vanessa
name: Kobelt, Peter
name: Goebel-Stengel, Miriam
name: Hofmann, Tobias
name: Rose, Matthias
name: Klapp, Burghard F.
name: Stengel, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: anorexigenic
subject: brain-gut-axis
subject: NUCB2
subject: satiation
subject: satiety
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Nesfatin-1 is well-established to induce an anorexigenic effect. Recently, nesfatin-130−59, was identified as active core of full length nesfatin-11−82 in mice, while its role in rats remains unclear. Therefore, we investigated the effects of nesfatin-130−59 injected intracerebroventricularly (icv) on the food intake microstructure in rats. To assess whether the effect was also mediated peripherally we injected nesfatin-130−59 intraperitoneally (ip). Since obesity affects the signaling of various food intake-regulatory peptides we investigated the effects of nesfatin-130−59 under conditions of diet- induced obesity (DIO). Male Sprague–Dawley rats fed ad libitum with standard diet were icv cannulated and injected with vehicle (5 μl ddH2O) or nesfatin-130−59 at 0.37, 1.1, and 3.3 μg (0.1, 0.3, 0.9 nmol/rat) and the food intake microstructure assessed using a food intake monitoring system. Next, naïve rats were injected ip with vehicle (300 μl saline) or nesfatin-130−59 (8.1, 24.3, 72.9 nmol/kg). Lastly, rats were fed a high fat diet for 10 weeks and those developing DIO were icv cannulated. Nesfatin-1 (0.9 nmol/rat) or vehicle (5 μl ddH2O) was injected icv and the food intake microstructure assessed. In rats fed standard diet, nesfatin-130−59 caused a dose-dependent reduction of dark phase food intake reaching significance at 0.9 nmol/rat in the period of 4–8 h post injection (−29%) with the strongest reduction during the fifth hour (−75%), an effect detectable for 24 h (−12%, p < 0.05 vs. vehicle). The anorexigenic effect of nesfatin-130−59 was due to a reduction in meal size (−44%, p < 0.05), while meal frequency was not altered compared to vehicle. In contrast to icv injection, nesfatin-130−59 injected ip in up to 30-fold higher doses did not alter food intake. In DIO rats fed high fat diet, nesfatin-130−59 injected icv reduced food intake in the third hour post injection (−71%), an effect due to a reduced meal frequency (−27%, p < 0.05), while meal size was not altered. Taken together, nesfatin-130−59 is the active core of nesfatin-11−82 and acts centrally to reduce food intake in rats. The anorexigenic effect depends on the metabolic condition with increased satiation (reduction in meal size) under normal weight conditions, while in DIO rats satiety (reduction in meal frequency) is induced.
Carbon Monoxide Poisoning : Hospitalizations and Deaths in Canada
Creators: name: Cohen, Irwin
name: Garis, Len
name: Rajabali, Fahra
name: Pike, Ian, 1958-
Publisher: name: The University of British Columbia
Year: 2021

description: The purpose of this research note is to draw attention to the number of carbon monoxide poisonings and deaths in Canada, which is, to some degree, preventable through the implementation of legislation requiring all new constructions to have installed and functioning CO alarms as the current built environment does not have this requirement. In effect, this research note is a call for retrospective regulation to require the built environment to install CO alarms in all existing residences.
Weiterentwicklung des Geruchsmessverfahrens für Bauprodukte
Creators: name: Brandt, S.
name: Brozowski, Frank
name: Horn, Wolfgang
name: Plehn, Wolfgang
Publisher: name: My University
Year: 2021

description: Emissions or odours occurring from building products and furnishings for interiors, like floor coverings or wall panels, should not have a negative impact on well-being or health. Odours can be measured applying the standard ISO 16000-28 "Indoor air - Determination of odour emissions from building products using test chambers". It describes among other procedures the assessment of perceived intensity with comparative scale by a group of panellists. In the study presented here, proposals for further technical development of the methodology are discussed to increase the reproducibility of measurement results. The sampling procedure and evaluation method of perceived intensity are investigated in particu-lar because they have a major influence at the assessment of construction products applying the procedure of the Commit-tee for Health Evaluation of Building Products. © 2021, VDI Fachmedien GmBbH & Co.. All rights reserved.
Kuli ngi daw = (La force sacrée du mil) : de la religion du mil à l'Eucharistie chrétienne chez les Gizigas du Nord Cameroun.
Creators: name: Jaouen, René.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Religion, History of.

description: Dix ans après la fin du Concile Vatican II, Paul VI renouvelait la doctrine missionnaire du Décret Ad Gentes et de la Déclaration Nostra Aetate par son Exhortation Apostolique Evangelii Nuntiandi sur l'Evangélisation dans le monde moderne, en date du 8 décembre 1975. Il disait alors que "L'Église évangélise lorsque, par la seule puissance divine du message qu'elle proclame (cf. Rom 1.16: 1 Cor 1, 18;2.4), elle cherche à convertir en même temps la conscience personnelle et collective des hommes, l'activité dans laquelle ils s'engagent, la vie et le milieu concrets qui sont les leurs" (E.N.18). Ce qui est à convertir, c'est donc, non seulement les consciences individuelles, mais aussi ce que le Concile a appelé ailleurs les cultures (G.S. 53). Et Paul VI d'insister sur la profondeur de cette conversion: il s'agit selon lui "d'atteindre et comme de bouleverser par la force de l'Évangile les critères de jugement, les valeurs déterminantes, les points d'intérêt, les lignes de pensée, les sources inspiratrices et les modèles de vie de l'humanidessein du salut" (E.N.19). L'hypothèse de cette recherche, c'est qu'il importe de traduire, non seulement les éléments secondaires, mais la totalité du langage ("matière et forme", symbole, signifiants). Pour atteindre à la profondeur que visait Paul VI, il ne faut pas commencer par faire éclater la structure du langage, en imposant des "limites convenables" (G.S.44) qui seraient des limites à priori étrangères à l'esprit de l'Incarnation. La pratique de l'Eucharistie dans les jeunes Églises d'Afrique fournit un excellent terrain pour vérifier cette hypothèse dans toutes ses dimensions, implications et conséquences. (Abstract shortened by UMI.)
Auseinandersetzung mit Herkunft - Wohnen von Großeltern
Creators: name: Amstad, Sabine
Publisher: name: Athena
Year: 2009
Subjects: subject: Architektur mit Kindern und Jugendlichen
subject: Staatsinstitut für Schulqualität und Bildungsforschung München
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Erprobter Unterrichtsimpuls im Studienbuch Raum erfahren - Raum gestalten. Architektur mit Kindern und Jugendlichen für die Aus- und Weiterbildung von Lehrpersonen. Die Publikation bündelt wissenschaftliche Forschungen zur Raum- und Architekturwahrnehmung mit methodischen Fragen zur Vermittlung des Themas in verschiedenen Schulstufen.
Rechtsgutachten zum Schutz von terrestrischen Nichtzielarten einschließlich der biologischen Vielfalt vor den Auswirkungen von Pflanzenschutzmitteln
Creators: name: Klinger, Remo
name: Borwieck, Karoline
name: Douhaire, Caroline
Publisher: name: My University
Year: 2017
Subjects: subject: Pflanzenschutzgesetz
subject: Biologische Vielfalt
subject: terrestrische Nichtzielarten
subject: Auswirkungen von Pflanzenschutzmitteln
subject: Biodiversität
subject: Chemikalien

description: Das Rechtsgutachten dient der Überprüfung einer vom Umweltbundesamt für die Zulassung von Pflanzenschutzmitteln vorgeschlagenen Anwendungsbestimmung (Anwendungsvorbehalt), die den Schutz der ⁠Biodiversität⁠ vor unannehmbaren Risiken durch Nahrungsnetzeffekte, sog. indirekte Effekte, sicherstellen soll. Demnach sollen Pflanzenschutzmittel mit erheblichen Nahrungsnetzeffekten zukünftig nur dort anwendbar sein, wo unannehmbare indirekte Auswirkungen durch das Vorhandensein ökologischer Ausgleichsflächen kompensiert werden. Die Gutachter schlussfolgern, dass diesem Vorschlag sowohl auf europäischer, als auch nationaler Ebene keine rechtlichen Hemmnisse entgegenstünden.
Oral tolerance and immune mechanisms in food-induced diabetes.
Creators: name: Rowsell, Paul.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Health Sciences, Nutrition.

description: Diet controls $\sim$80% of type-I (insulin-dependent) diabetes in the diabetes-prone BioBreeding (BBdp) rat. This study was designed to define the relationship among diet, the gut immune system and the pancreas. BB rats were fed either a diabetogenic NIH-07 (NIH) diet or the diabetes protective, hydrolysed casein (HC) diet. Bovine serum albumin (BSA), ovalbumin (OVA), sheep red blood cells (SRBC) and NIH were given by gavage daily for 5 days. Both BBdp and the diabetes resistant BBc rat when fed NIH became unresponsive in antibody production to NIH antigens. None of the other oral antigen treatments induced tolerance. In delayed-type hypersensitivity (DTH) reactions, footpad injection of NIH resulted in lower DTH reactions and less increase in popliteal lymph node weight when animals were fed NIH than HC. We conclude that oral tolerance, both cell-mediated and humoral, to diabetogenic antigens is inducible in both strains of BB rats. This required daily feeding unlike in other rat strains. The depressed DTH reaction in the animals fed NIH indicates no link between the systemic Th1 DTH reaction to NIH and the Th1 food-induced diabetogenesis. Neonatal intrathymic injection of autoclaved NIH did not affect diabetes incidence, suggesting systemic exposure to these food antigens was not protective. Feeding neonatal BBdp rats a diabetogenic diet between 4 and 7d of age significantly delayed diabetes and reduced incidence. This effect was seen with the NIH diet and its diabetogenic component, wheat gluten. We conclude that early exposure to food diabetogens is protective against food-induced diabetes, indicating a crucial link between the local gut immune system and autoimmunity against pancreatic $\beta$ cells.
Factors predicting local effectiveness of impaired driving laws, British Columbia, Canada
Creators: name: Brubacher, Jeffrey
name: Chan, Herbert
name: Erdelyi, Shannon
name: Asbridge, Mark
name: Schuurman, Nadine
Publisher: name: The University of British Columbia
Year: 2022

description: Objective: In 2010 British Columbia introduced laws allowing police to suspend licenses and impound vehicles of drinking drivers based on roadside breathalyzer results. This study examines regional variation in the effectiveness of the new laws and identifies local factors that may have modified the law’s effectiveness. Methods: First, we used an interrupted time series design with a negative binomial mixed model to study the change in rate of single vehicle nighttime crashes (SVNCs, a proxy for alcohol related crashes) in each of British Columbia’s 118 police patrol after the laws were introduced. Next, the role of explanatory factors was studied using patrollevel estimated percent reduction in SVNCs as the response variable in a linear regression model with spatially autocorrelated errors that included explanatory factors as covariates. Results: The average rate of SVNCs across police patrols was 12% lower (95%CI:9.1%-14.8%) following the new laws, and all police patrols included in our model had estimated reductions in SVNCs. Reductions in SVNCs were positively associated with the number of alcohol serving establishments per capita and with socioeconomic status and negatively associated with baseline rates of traffic citations. Conclusions: The laws were associated with improved road safety across the province but were least effective in more socioeconomically disadvantaged regions. Increased effectiveness in regions with more alcohol serving establishments may have indicated a specific deterrent effect on drinking drivers who frequent these establishments The laws were also more effective in regions with lower baseline traffic law enforcement (i.e. lower citation rates), perhaps because media reports about the IRP regime created unease in drinking drivers who previously knew that their risk of punishment for traffic law violations was low.
Health and Crime Outcomes During and Following Prison Release Among a Prospective Cohort of Men With a History of Injecting Drug Use
Creators: name: Cossar, Reece D.
Publisher: name: Swinburne
Year: 2024

description: People with a history of substance use, particularly injecting drug use, are overrepresented among people in prison. The aim of this thesis was to examine the health outcomes during periods of imprisonment and the health and crime outcomes within 12 months following release from prison among a prospective cohort of men with a history of injecting drug use in Victoria, Australia. This thesis shows there is a need to increase resources and reallocate those current available toward an evidence-based and health-oriented response for people engaging in non-violent and drug-related crime.
Preparation of highly selective polyamide membranes for gas separation applications.
Creators: name: Tabe Mohhamadi, Abdulreza.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Engineering, Chemical.

description: The use of reverse osmosis (RO) and ultrafiltration (UF) membranes for separation of gas mixtures is a relatively new development. Most of asymmetric RO and UF membranes which are useful in liquid separation fail to be effective in gas separation because some of the pores on the membrane surface are too large and have no separation capacity. The selectivity of these membranes can be improved by blocking the large pores with a second material. This process is known as coating and has proven to be highly effective in upgrading RO & UF membranes for gas separation. In this study membranes were prepared from an aromatic polyamide (PA) polymer and coated by silicone rubber. In a set of experiments, the permeation rates of six experimental gases through these membranes were measured at different pressures. The ideal separation factors higher than those reported in the literature were obtained. These results show that PA membranes are highly capable of separating the gases under investigation. The resistance model was employed to analyze the data and to explain the performance of this polymeric membrane. In another set of experiments, mixtures of CH$\sb4$/CO$\sb2$ with known compositions, and O$\sb2$/N$\sb2$ (air), were separated using coated PA membranes. The actual separation factors of 64 to 166 for CO$\sb2$/CH$\sb4$ and 8.7 for O$\sb2$/N$\sb2$ systems obtained in this set of experiments were higher than those reported in the literature. A "membrane-self-sealing" gas separation cell design allowed for a leak-free system with a leak rate of ${}1.2\times10\sp{-9}$ cm$\sp3$/s. This level of leak is few orders of magnitude lower than similar existing systems. This cell design facilitates experiments involving the separation of air in which a perfect sealing is necessary in order to prevent the oxygen enriched permeate to mix with the leaking air. The new separation cell was installed in a fully automated system which operates gas permeation experiments using a process control computer program. The system is designed such that measurement of permeation rates as low as $1\times10\sp{-8}$ cm$\sp3$/s becomes possible. The new system is ideal for experiments involving homogeneous membrane and/or low permeable gases such as nitrogen and methane.
Modelling and control problems of distillation column.
Creators: name: Jafri, M. Noman.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1964
Subjects: subject: Engineering, Electronics and Electrical.

description: A linearised dynamic model of a 10-plate binary distillation column was obtained by perturbation technique. The control of the column was considered by two methods: one manipulated variable (reflux) control and two manipulated variables (reflux and reboil) control. These methods were studied on an analog computer. In both cases optimal parameters of the controllers were obtained by integral of the square error criterion for disturbances in the feed composition. The effect of interaction in two manipulated variable control was also studied. It was concluded that two manipulated variable control was practical since it ensures reliability in the operation of the column.
title: The credibility of the ECB’s inﬂation target in times of corona
title: new evidence from an online survey
titleType: Subtitle
Creators: name: Coleman, Winnie
name: Nautz, Dieter
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Credibility of Inflation Targets
subject: Household Inflation Expectations
subject: Online Surveys
subject: Coronavirus pandemic
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: Evidence on the credibility of a central bank’s inflation target typically refers to the anchoring of survey-based measures of inflation expectations. However, both the survey question and the anchoring criteria are only loosely connected to the actual inflation target used in monetary policy practice. By using the exact wording of the ECB’s definition of price-stability, we started a representative online survey of German citizens in January 2019 that is designed to measure the time-varying credibility of the inflation target. Our results indicate that credibility has significantly decreased in our sample period, particularly in the course of the coronavirus pandemic. Interestingly, even though inflation rates in Germany have been clearly below 2% for several years, credibility has declined mainly because Germans increasingly expect that inflation will be much higher than 2% over the medium term.
Synthesis of linear sequential machines using cyclic subspaces.
Creators: name: Farley, J. W. Jacques.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1970
Subjects: subject: Engineering, Electronics and Electrical.

description: The material presented in this thesis can be divided into two major topics: Controllability and observability of linear systems, where these principles are presented in terms of cyclic subspaces. This is a new approach that gives further insight in the physical aspects of controllability and observability and it is also used for the construction of controllable and observable linear sequential machines. Shift register realization of linear sequential machines, where a general realization algorithm is presented. The algorithm was implemented for parallel shift register realization.
title: N ,N′ ‐Ethylene‐Bridged Bis‐2‐Aryl‐Pyrrolinium Cations to E ‐Diaminoalkenes
title: Non‐Identical Stepwise Reversible Double‐Redox Coupled Bond Activation Reactions
titleType: Subtitle
Creators: name: Nayak, Mithilesh Kumar
name: Stubbe, Jessica
name: Neuman, Nicolás I.
name: Narayanan, Ramakirushnan Suriya
name: Maji, Sandipan
name: Schulzke, Carola
name: Chandrasekhar, Vadapalli
name: Sarkar, Biprajit
name: Jana, Anukul
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: chemistry
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: This work presents a stepwise reversible two‐electron transfer induced hydrogen shift leading to the conversion of a bis‐pyrrolinium cation to an E ‐diaminoalkene and vice versa. Remarkably, the forward and the reverse reaction, which are both reversible, follow two completely different reaction pathways. Establishing such unprecedented property in this type of processes was possible by developing a novel synthetic route towards the starting dication. All intermediates involved in both the forward and the backward reactions were comprehensively characterized by a combination of spectroscopic, crystallographic, electrochemical, spectroelectrochemical, and theoretical methods. The presented synthetic route opens up new possibilities for the generation of multi‐pyrrolinium cation scaffold‐based organic redox systems, which constitute decidedly sought‐after molecules in contemporary chemistry.
3364822.pdf
Creators: name: Li, Kwai Hei
name: Fu, Wai Yuen
name: Cheung, Yuk
name: Wong, Kenneth Kin-Yip
name: wang, yongjin
name: Lau, Kei May
name: Choi, H.
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Document
title: Schritt für Schritt zum nachhaltigen Lieferkettenmanagement
title: Schritt für Schritt zum nachhaltigen Lieferkettenmanagement
titleType: AlternativeTitle
Creators: name: Weiss, Daniel
name: Hajduk, Thomas
name: Knopf, Jutta
Publisher: name: My University
Year: 2017

description: Ein Großteil der Umweltbelastungen entsteht in der Lieferkette. Daraus ergeben sich hier große Reduktionspotenziale für kleinere und mittelständische Betriebe. Die Broschüre ist insbesondere für mittelständische Unternehmen interessant, die bereits ein solides Fundament an Umwelt- oder Nachhaltigkeitspraktiken in ihren Werkshallen und Büros gelegt haben und nun beim nachhaltigen Lieferkettenmanagement erste Schritte gehen möchten. Für Unternehmen, die bereits ein Umweltmanagementsystem nach EMAS oder ISO 14001 eingeführt haben, bietet der Leitfaden Ansatzpunkte für das Management indirekter Umweltaspekte und die Betrachtung des Lebensweges von Produkten und Dienstleistungen. Quelle: Verlagsinformation
Exploring biased agonism at the chemokine receptor CCR4: Implications for targeting in allergic disease
Creators: name: Anderson, Caroline A.
Publisher: name: Imperial College London
Year: 2017

description: The chemokine receptor CCR4 and its ligands CCL17 and CCL22 are strongly implicated in the pathogenesis of allergic diseases, notably asthma. This stems from their involvement in recruiting pro-inflammatory T helper 2 (Th2) cells to inflammatory sites. Targeting CCR4 in allergy, however, is complicated by expression of the receptor on homeostatic T regulatory (T reg) cells. Strategies for selectively targeting CCR4 on Th2 cells are therefore desirable to avoid the development of autoimmune disease. An emerging solution relates to accumulating evidence that CCL17 and CCL22 are functionally selective ligands of their receptor. This thesis therefore examined the hypothesis that CCL17 and CCL22 are biased agonists of CCR4 and induce differential signalling pathways that may be exploited therapeutically. CCR4 expression at the cell surface was found to be strictly regulated in experiments investigating CCR4 turnover, with the receptor undergoing both ligand-induced and constitutive internalization. Importantly, CCR4 was constitutively degraded and replenished at the cell surface by de novo protein synthesis. Truncation of the CCR4 C-terminus by 40 amino acids revealed that this region of CCR4 is important for ligand-induced internalization and chemotaxis. Comparing the chemotactic responsiveness of in vitro-polarized human Th2 cells revealed a lack of redundancy for CCL17 and CCL22. Surprisingly, directional migration of Th2 cells was observed along gradients of CCL22 but not along CCL17 gradients. Conversely, exposure of Th2 cells to CCL17 induced greater adhesion than did exposure to CCL22. Bias at CCR4 was further investigated by comparing the transcriptomes induced in Th2 cells following culture with CCL17 and CCL22. Despite variation between biological replicates, differentially expressed genes were identified that may have implications for T cell activation. Collectively, the data support a model in which CCL22 acts predominantly as a chemoattractant of CCR4+ cells whilst CCL17 plays alternative roles in cell adhesion and retention at inflammatory sites. Fine-tuning CCR4 activity using biased ligands could represent an exciting opportunity for targeting this receptor in allergic diseases.
Estimation of Directed Effective Connectivity from fMRI Functional Connectivity Hints at Asymmetries of Cortical Connectome
Creators: name: Gilson, Matthieu
name: Moreno-Bote, Ruben
name: Ponce-Alvarez, Adrian
name: Ritter, Petra
name: Deco, Gustavo
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The brain exhibits complex spatio-temporal patterns of activity. This phenomenon is governed by an interplay between the internal neural dynamics of cortical areas and their connectivity. Uncovering this complex relationship has raised much interest, both for theory and the interpretation of experimental data (e.g., fMRI recordings) using dynamical models. Here we focus on the so-called inverse problem: the inference of network parameters in a cortical model to reproduce empirically observed activity. Although it has received a lot of interest, recovering directed connectivity for large networks has been rather unsuccessful so far. The present study specifically addresses this point for a noise-diffusion network model. We develop a Lyapunov optimization that iteratively tunes the network connectivity in order to reproduce second-order moments of the node activity, or functional connectivity. We show theoretically and numerically that the use of covariances with both zero and non-zero time shifts is the key to infer directed connectivity. The first main theoretical finding is that an accurate estimation of the underlying network connectivity requires that the time shift for covariances is matched with the time constant of the dynamical system. In addition to the network connectivity, we also adjust the intrinsic noise received by each network node. The framework is applied to experimental fMRI data recorded for subjects at rest. Diffusion-weighted MRI data provide an estimate of anatomical connections, which is incorporated to constrain the cortical model. The empirical covariance structure is reproduced faithfully, especially its temporal component (i.e., time-shifted covariances) in addition to the spatial component that is usually the focus of studies. We find that the cortical interactions, referred to as effective connectivity, in the tuned model are not reciprocal. In particular, hubs are either receptors or feeders: they do not exhibit both strong incoming and outgoing connections. Our results sets a quantitative ground to explore the propagation of activity in the cortex.
Surfactant phospholipid metabolism and respiratory failure in lung transplantation
Creators: name: Thakuria, Louit
Publisher: name: Imperial College London
Year: 2017

description: Primary graft dysfunction (PGD) after lung transplantation is a multi-factorial syndrome of postoperative lung injury that is similar to the acute respiratory distress syndrome. PGD is a major risk factor for chronic lung allograft dysfunction and perioperative death. Pulmonary surfactant dysfunction is frequently seen in PGD and contributes to respiratory failure. Surfactant is primarily comprised of lipids, of which phosphatidylcholine (PC) species predominate. Dipalmitoylphosphatidylcholine (DPPC) is the most surface-active species that normally represents over half of all airway PC content. Combining electrospray ionisation tandem mass spectrometry with deuterium labelling of Kennedy’s PC synthetic pathway can assess surfactant phospholipid flux, with a molecular specificity that differentiates between lipids with unique functions. This technique was used to quantify perioperative phospholipid metabolic disruption in lung transplantation. The same technique was used in an ex vivo human lung model to isolate the pulmonary contribution to systemic phospholipid metabolism, and evaluate Kennedy pathway integrity during ex vivo lung perfusion (EVLP). Airway DPPC content was severely reduced after transplantation, and was associated with impaired oxygenation. Variations in Kennedy pathway activity were associated with impaired graft function for months after transplantation. Perioperative flux of phospholipids, like DPPC and polyunsaturated PC species, were strong predictors of poor postoperative lung function. Deuterium labelled ex vivo experiments confirmed continued Kennedy pathway dependent surfactant phospholipid synthesis during EVLP, and could represent a protective mechanism against PGD in clinical EVLP. Ex vivo lungs secreted a different phospholipid profile into the perfusate that is enriched with polyunsaturated PC when compared to the airways, providing compelling evidence of the previously hypothesized basolateral phospholipid secretion by the alveolar epithelium. These polyunsaturated PC species are precursors of numerous inflammatory mediators, and could contribute to PGD. Continued investigation of phospholipid flux through the Kennedy pathway could identify novel biomarkers and therapeutic targets in lung transplantation.