cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Parameter estimation for additive hazards model with partly interval-censored failure time data using a penalized likelihood approach
Creators: name: Rathnayake, Kasun Dananjaya
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: In the context of failure time data, interval censoring is a censoring type which has become increasingly prevalent in many areas, including medical, financial, actuarial and sociological studies. In interval-censored data, the actual failure time is neither exactly observed nor right-censored nor left-censored, but one can establish boundaries of an interval within which the survival event has occurred. The aim of this thesis is to develop a maximum penalized log-likelihood (MPL) method which estimates model parameters of the semiparametric additive hazards model with partly interval-censored failure time data. This data will contain exactly observed, left-censored, finite interval-censored and right-censored data. This MPL method estimates the regression coefficients and the underlying non-parametric baseline hazard function, simultaneously, by imposing non-negativity constraints on the baseline hazard and the overall hazard function. We approximate infinite dimensional baseline hazard from a finite number of non-negative basis functions. The chosen MPL method guarantees the smoothness of the baseline hazard estimates, which clearly depicted the trend of how the estimates changed over time. We adopted the augmented Lagrangian method to solve this constraint optimization problem, and the estimates were obtained simultaneously using the Newton and multiplicative iterative (Newton-MI) algorithm followed by line-search steps. The asymptotic properties of these derived constrained MPL estimators were studied when the number of basis functions was fixed and when it went to infinity. We investigated the performance of this proposed MPL method by conducting simulation studies for both right-censored data and partly interval-censored data. Both of the simulation studies demonstrated that our method worked well for small and large datasets as well as small and large censoring proportions. The derived asymptotic standard deviation formula was generally accurate in approximating the standard deviation of the constrained MPL estimates. In addition, we also made comparisons between our MPL method and existing parameter estimation methods developed by Aalen (1980) and Lin & Ying (1994). Results show that our MPL method provided better estimates. In a real data analysis, we applied our MPL method to fit the additive hazards model to a melanoma data set with all types of censoring, which was provided by the Melanoma Institute of Australia.
Neisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3
Creators: name: Spoerry, Christian
name: Karlsson, Jens
name: Aschtgen, Marie-Stephanie
name: Loh, Edmund
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Neisseria meningitidis (meningococcus) is a common bacterial colonizer of the human nasopharynx but can occasionally cause very severe systemic infections with rapid onset. Meningococci are able to degrade IgA encountered during colonization of mucosal membranes using their IgA1-specific serine protease. During systemic infection, specific IgG can induce complement-mediated lysis of the bacterium. However, meningococcal immune evasion mechanisms in thwarting IgG remain undescribed. In this study, we report for the first time that the meningococcal IgA1-specific serine protease is able to degrade IgG3 in addition to IgA. The IgG3 heavy chain is specifically cleaved in the lower hinge region thereby separating the antigen binding part from its effector binding part. Through molecular characterization, we demonstrate that meningococcal IgA1-specific serine protease of cleavage type 1 degrades both IgG3 and IgA, whereas cleavage type 2 only degrades IgA. Epidemiological analysis of 7581 clinical meningococcal isolates shows a significant higher proportion of cleavage type 1 among isolates from invasive cases compared to carrier cases, regardless of serogroup. Notably, serogroup W cc11 which is an increasing cause of invasive meningococcal disease globally harbors almost exclusively cleavage type 1 protease. Our study also shows an increasing prevalence of meningococcal isolates encoding IgA1P cleavage type 1 compared to cleavage type 2 during the observed decade (2010–2019). Altogether, our work describes a novel mechanism of IgG3 degradation by meningococci and its association to invasive meningococcal disease.
MPEC 2024-G156 : 2013 DZ
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Genuine $N$-partite entanglement without $N$-partite correlation functions
Creators: name: Tran, Minh Cong
name: Zuppardo, Margherita
name: de Rosier, Anna
name: Knips, Lukas
name: Laskowski, Wiesław
name: Paterek, Tomasz
name: Weinfurter, Harald
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A genuinely $N$-partite entangled state may display vanishing $N$-partite correlations measured for arbitrary local observables. In such states the genuine entanglement is noticeable solely in correlations between subsets of particles. A straightforward way to obtain such states for odd $N$ is to design an `anti-state' in which all correlations between an odd number of observers are exactly opposite. Evenly mixing a state with its anti-state then produces a mixed state with no $N$-partite correlations, with many of them genuinely multiparty entangled. Intriguingly, all known examples of `entanglement without correlations' involve an \emph{odd} number of particles. Here we further develop the idea of anti-states, thereby shedding light on the different properties of even and odd particle systems. We conjecture that there is no anti-state to any pure even-$N$-party entangled state making the simple construction scheme unfeasable. However, as we prove by construction, higher-rank examples of `entanglement without correlations' for arbitrary even $N$ indeed exist. These classes of states exhibit genuine entanglement and even violate an $N$-partite Bell inequality, clearly demonstrating the non-classical features of these states as well as showing their applicability for quantum communication complexity tasks.
description: 8 pages
A reconsideration of red slip tableware at Pompeii
Creators: name: Pont, Jaye
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The assessment of red slip tableware at Pompeii has traditionally involved the study of pottery from AD 79 contexts housed in the National Archaeological Museum of Naples and storerooms of Pompeii and Herculaneum. These collections represent only a partial view of the ceramics in use in Pompeii because they reflect the priorities and values of past excavators, who customarily retained only well preserved or interesting vessels. Pompeii provides an important chronological marker in the study of Roman ceramics and it is therefore crucial that the pottery in use in the city is comprehensively and accurately documented. This thesis investigates red slip pottery found in pre-AD 79 contexts in two regions of the city. The systematic and detailed examination of these ceramics has enabled a comprehensive and scientific assessment of red slip pottery found at Pompeii. Determination of the provenance of this tableware enhances current knowledge and understanding of local, regional, and inter-regional trade patterns operating in Campania. Examination of the distribution of red slip pottery throughout an entire city block reveals distinct patterns in the use of these ceramics within Pompeian society. The results of this thesis furnish new insight into the production and evolution of red slip tableware in Campania and highlight the significance of this ceramic production to the economy of Pompeii and Campania.
Additional file 1: Table S1. of Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients
Creators: name: Hundeshagen, Gabriel
name: Herndon, David
name: Capek, Karel
name: Branski, Ludwik
name: Voigt, Charles
name: Killion, Elizabeth
name: Janos Cambiaso-Daniel
name: Sljivich, Michaela
name: Crescenzo, Andrew De
name: Mlcak, Ronald
name: Kinsky, Michael
name: Finnerty, Celeste
name: Norbury, William
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Statistical summary of secondary study endpoints. All data are presented as count (percentage) or mean (standard deviation). (DOCX 12 kb)
Additional file 1 of Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP)
Creators: name: Guo, Weihong
name: Chen, Zhian
name: Feng, Xiaoli
name: Shen, Guodong
name: Huang, Huilin
name: Liang, Yanrui
name: Zhao, Bingxia
name: Li, Guoxin
name: Hu, Yanfeng
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1. Additional figures S1–S20.
Effect of meson cloud on the jet nuclear modification factor in $pA$ collisions
Creators: name: Zakharov, B. G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the effect of the nucleon meson cloud on centrality dependence of the jet nuclear modification factor $R_{pA}$. We find that the meson-baryon Fock components may lead to a noticeable deviation of $R_{pA}$ from unity. Our results for $R_{pA}$ show the same tendency as that observed by ATLAS in $p+Pb$ collisions at $\sqrt{s}=5.02$ TeV. The meson cloud suppresses the central jet events and enhances the peripheral jet events. But quantitatively the effect is somewhat smaller than in the data.
description: 5 pages, 2 figures
Supplementary Figure S1 from Bioinformatic prediction of putative metallothioneins in non-ciliate protists
Creators: name: Balzano, Sergio
name: Sardo, Angela
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Environmental Science
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Full length alignment of the putative MTs from heterokonts and dinoflagellates. Numbers correspond to the amino acid position with respect to the known MT from Aureococcus anophagefferens (XP_009037419).
First evidence of external disc photoevaporation in a low mass star forming region: the case of IM Lup
Creators: name: Haworth, Thomas J.
name: Facchini, Stefano
name: Clarke, Cathie J.
name: Cleeves, L. Ilsedore
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We model the radiatively driven flow from IM Lup -- a large protoplanetary disc expected to be irradiated by only a weak external radiation field (at least 10$^4$ times lower than the UV field irradiating the Orion Nebula Cluster proplyds). We find that material at large radii ($>400$AU) in this disc is sufficiently weakly gravitationally bound that significant mass loss can be induced. Given the estimated values of the disc mass and accretion rate, the viscous timescale is long ($\sim10$Myr) so the main evolutionary behaviour for the first Myr of the disc's lifetime is truncation of the disc by photoevaporation, with only modest changes effected by viscosity. We also produce approximate synthetic observations of our models, finding substantial emission from the flow which can explain the CO halo observed about IM Lup out to $\geq1000$AU. Solutions that are consistent with the extent of the observed CO emission generally imply that IM Lup is still in the process of having its disc outer radius truncated. We conclude that IM Lup is subject to substantial external photoevaporation, which raises the more general possibility that external irradiation of the largest discs can be of significant importance even in low mass star forming regions.
description: 5 pages, 5 figures. Accepted for publication in MNRAS letters
Comparing topologies on linearly recursive sequences
Creators: name: Kaoutit, Laiachi El
name: Saracco, Paolo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Commutative Algebra (math.AC)
subject: General Topology (math.GN)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: Primary: 13J05, 40A05, 16W70, Secondary: 13J10, 54A10, 16W80

description: The space of linearly recursive sequences of complex numbers admits two distinguished topologies. Namely, the adic topology induced by the ideal of those sequences whose first term is $0$ and the topology induced from the Krull topology on the space of complex power series via a suitable embedding. We show that these topologies are not equivalent.
description: 8 pages
A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner
Creators: name: Yang, Qiankun
name: Zhang, Jianguo
name: Liu, Feixue
name: Chen, Huizhen
name: Zhang, Wei
name: Yang, Haitao
name: He, Nana
name: Dong, Jingquan
name: Zhao, Panpan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates or supernatants. This process triggered NLRP3 levels upregulation, ASC oligomerization, as well as dot gathering of NLRP3 and speck-like signals of ASC in the cytoplasm. MCC950 blocked A. caviae mediated IL-1β release. Meanwhile, NLRP3 inflammasome mediated the release of IL-1β in dose- and time-dependent manners, and the release of IL-1β was dependent on active caspase-1, as well as NLRP3 inflammasome was activated by potassium efflux and cathepsin B release ways. A. caviae also enhanced TLR2 levels, and deletion of TLR2 obviously decreased IL-1β secretion. What’s more, A. caviae resulted in NF-κB p65 nuclear translocation partly in a TLR2-dependent manner. Blocking NF-κB using BAY 11-7082 almost completely inhibited NLRP3 inflammasome first signal pro-IL-1β expression. Blocking TLR2, NF-κB, NLRP3 inflammasome significantly downregulated IL-1β release and TNF-α and IL-6 levels. These data illustrate that A. caviae caused IL-1β secretion in PMs is controlled by NLRP3 inflammasome, of which is mediated by NF-κB pathway and is partially dependent on TLR2, providing basis for drugs against A. caviae.
Enhancing the significance of gravitational wave bursts through signal classification
Creators: name: Vinciguerra, S.
name: Drago, M.
name: Prodi, G. A.
name: Klimenko, S.
name: Lazzaro, C.
name: Necula, V.
name: Salemi, F.
name: Tiwari, V.
name: Tringali, M. C.
name: Vedovato, G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The quest to observe gravitational waves challenges our ability to discriminate signals from detector noise. This issue is especially relevant for transient gravitational waves searches with a robust eyes wide open approach, the so called all- sky burst searches. Here we show how signal classification methods inspired by broad astrophysical characteristics can be implemented in all-sky burst searches preserving their generality. In our case study, we apply a multivariate analyses based on artificial neural networks to classify waves emitted in compact binary coalescences. We enhance by orders of magnitude the significance of signals belonging to this broad astrophysical class against the noise background. Alternatively, at a given level of mis-classification of noise events, we can detect about 1/4 more of the total signal population. We also show that a more general strategy of signal classification can actually be performed, by testing the ability of artificial neural networks in discriminating different signal classes. The possible impact on future observations by the LIGO-Virgo network of detectors is discussed by analysing recoloured noise from previous LIGO-Virgo data with coherent WaveBurst, one of the flagship pipelines dedicated to all-sky searches for transient gravitational waves.
Enhancement of Physical Layer Security Using Destination Artificial Noise Based on Outage Probability
Creators: name: Rahmanpour, Ali
name: Vakili, Vahid T.
name: Razavizadeh, S. Mohammad
Publisher: name: arXiv
Year: 2017
Subjects: subject: Information Theory (cs.IT)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: In this paper, we study using Destination Artificial Noise (DAN) besides Source Artificial Noise (SAN) to enhance physical layer secrecy with an outage probability based approach. It is assumed that all nodes in the network (i.e. source, destination and eavesdropper) are equipped with multiple antennas. In addition, the eavesdropper is passive and its channel state and location are unknown at the source and destination. In our proposed scheme, by optimized allocation of power to the SAN, DAN and data signal, a minimum value for the outage probability is guaranteed at the eavesdropper, and at the same time a certain level of signal to noise ratio (SNR) at the destination is ensured. Our simulation results show that using DAN along with SAN brings a significant enhancement in power consumption compared to methods that merely adopt SAN to achieve the same outage probability at the eavesdropper.
description: Accepted for publication in Wireless Personal Communications (Springer)
The autophagy-related proteins FvAtg4 and FvAtg8 are involved in virulence and fumonisin biosynthesis in Fusarium verticillioides
Creators: name: Wang, Yujie
name: Liu, Xin
name: Xu, Yujiao
name: Gu, Yiying
name: Zhang, Xinyue
name: Zhang, Mengxuan
name: Wen, Wen
name: Lee, Yin-Won
name: Shi, Jianrong
name: Mohamed, Sherif Ramzy
name: Goda, Amira A.
name: Wu, Huijun
name: Gao, Xuewen
name: Gu, Qin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Autophagy is the main intracellular degradation system by which cytoplasmic materials are transported to and degraded in the vacuole/lysosome of eukaryotic cells, and it also controls cellular differentiation and virulence in a variety of filamentous fungi. However, the contribution of the autophagic pathway to fungal development and pathogenicity in the important maize pathogen and mycotoxigenic fungus Fusarium verticillioides is still unknown. In this study, we characterized two autophagy-related proteins, FvAtg4 and FvAtg8. The F. verticillioides deletion mutants ΔFvAtg4 and ΔFvAtg8 were impaired in autophagosome formation, aerial hyphal formation, sexual growth, lipid turnover, pigmentation and fungal virulence. Interestingly, ΔFvAtg4 and ΔFvAtg8 were defective in fumonisin B1 (FB1) synthesis, which may have resulted from decreased intracellular levels of alanine in the mutants. Our results indicate that FvAtg4 and FvAtg8 contribute to F. verticillioides pathogenicity by regulating the autophagic pathway to control lipid turnover, fumonisin biosynthesis, and pigmentation during its infectious cycle.
Additional file 1: of Receptor of ghrelin is expressed in cutaneous neurofibromas of individuals with neurofibromatosis 1
Creators: name: Rozza-De-Menezes, Rafaela
name: Gaglionone, Nicolle
name: Andrade-Losso, Raquel
name: Siqueira, Orlando
name: Almeida, Lilian
name: Peruzini, Kamila
name: Guimarães-Filho, Marco
name: Brum, Carolina
name: Geller, Mauro
name: Cunha, Karin
Publisher: name: figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology

description: Supplementary information – Methods. Detailed information about immunohistochemistry and immunoquantification. (PDF 40 kb)
A powerful flare from Sgr A* confirms the synchrotron nature of the X-ray emission
Creators: name: Ponti, G.
name: George, E.
name: Scaringi, S.
name: Zhang, S.
name: Jin, C.
name: Dexter, J.
name: Terrier, R.
name: Clavel, M.
name: Degenaar, N.
name: Eisenhauer, F.
name: Genzel, R.
name: Gillessen, S.
name: Goldwurm, A.
name: Habibi, M.
name: Haggard, D.
name: Hailey, C.
name: Harrison, F.
name: Merloni, A.
name: Mori, K.
name: Nandra, K.
name: Ott, T.
name: Pfuhl, O.
name: Plewa, P. M.
name: Waisberg, I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the first fully simultaneous fits to the NIR and X-ray spectral slope (and its evolution) during a very bright flare from Sgr A*, the supermassive black hole at the Milky Way's center. Our study arises from ambitious multi-wavelength monitoring campaigns with XMM-Newton, NuSTAR and SINFONI. The average multi-wavelength spectrum is well reproduced by a broken power-law with $Γ_{NIR}=1.7\pm0.1$ and $Γ_X=2.27\pm0.12$. The difference in spectral slopes ($ΔΓ=0.57\pm0.09$) strongly supports synchrotron emission with a cooling break. The flare starts first in the NIR with a flat and bright NIR spectrum, while X-ray radiation is detected only after about $10^3$ s, when a very steep X-ray spectrum ($ΔΓ=1.8\pm0.4$) is observed. These measurements are consistent with synchrotron emission with a cooling break and they suggest that the high energy cut-off in the electron distribution ($γ_{max}$) induces an initial cut-off in the optical-UV band that evolves slowly into the X-ray band. The temporal and spectral evolution observed in all bright X-ray flares are also in line with a slow evolution of $γ_{max}$. We also observe hints for a variation of the cooling break that might be induced by an evolution of the magnetic field (from $B\sim30\pm8$ G to $B\sim4.8\pm1.7$ G at the X-ray peak). Such drop of the magnetic field at the flare peak would be expected if the acceleration mechanism is tapping energy from the magnetic field, such as in magnetic reconnection. We conclude that synchrotron emission with a cooling break is a viable process for Sgr A*'s flaring emission.
description: Accepted for publication in MNRAS
Additional file 1: of A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction?
Creators: name: Miyashiro, Denis
name: Vieira, Ana
name: Trindade, Maria
name: Avancini, João
name: Sanches, José
name: Benard, Gil
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Immunohistochemistry staining for Foxp3, IL-4, IL-17 and IFN-γ of the biopsies of skin lesions. Material and methods for the immunohistochemistry stainings. (DOCX 16 kb)
Disruption of the accidental Dirac semimetal state in ZrTe$_{5}$ under hydrostatic pressure
Creators: name: Zhang, J. L.
name: Guo, C. Y.
name: Zhu, X. D.
name: Ma, L.
name: Zheng, G. L.
name: Wang, Y. Q.
name: Pi, L.
name: Chen, Y.
name: Yuan, H. Q.
name: Tian, M. L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the effect of hydrostatic pressure on the magnetotransport properties of the zirconium pentatelluride. The magnitude of resistivity anomaly gets enhanced with increasing pressure, but the transition temperature $T^{\ast}$ is almost independent of it. In the case of H $\parallel$ $b$, the quasi-linear magnetoresistance decreases drastically from 3300$\%$ (9 T) at ambient pressure to 400$\%$ (14 T) at 2.5 GPa. Besides, the change of the quantum oscillation phase from topological nontrivial to trivial is revealed around 2 GPa. Both demonstrate that the pressure breaks the accidental Dirac node in ZrTe$_{5}$. For H $\parallel$ $c$, in contrast, subtle changes can be seen in the magnetoresistance and quantum oscillations. In the presence of pressure, ZrTe$_{5}$ evolves from a highly anisotropic to a nearly isotropic electronic system, which accompanies with the disruption of the accidental Dirac semimetal state. It supports the assumption that ZrTe$_{5}$ is a semi-3D Dirac system with linear dispersion along two directions and a quadratic one along the third.
Higgs boson mass corrections in the $μν$SSM with effective potential methods
Creators: name: Zhang, Hai-Bin
name: Feng, Tai-Fu
name: Yang, Xiu-Yi
name: Zhao, Shu-Min
name: Ning, Guo-Zhu
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: To solve the $μ$ problem of the MSSM, the $μ$ from $ν$ Supersymmetric Standard Model ($μν$SSM) introduces three singlet right-handed neutrino superfields $\hatν_i^c$, which lead to the mixing of the neutral components of the Higgs doublets with the sneutrinos, producing a relatively large CP-even neutral scalar mass matrix. In this work, we analytically diagonalize the CP-even neutral scalar mass matrix and analyze in detail how the mixing impacts the lightest Higgs boson mass. We also give an approximate expression for the lightest Higgs boson mass. Simultaneously, we consider the radiative corrections to the Higgs boson masses with effective potential methods.
description: 22 pages, 4 figures, published in Phys. Rev. D
A Complete Basis of Helicity Operators for Subleading Factorization
Creators: name: Feige, Ilya
name: Kolodrubetz, Daniel W.
name: Moult, Ian
name: Stewart, Iain W.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Factorization theorems underly our ability to make predictions for many processes involving the strong interaction. Although typically formulated at leading power, the study of factorization at subleading power is of interest both for improving the precision of calculations, as well as for understanding the all orders structure of QCD. We use the SCET helicity operator formalism to construct a complete power suppressed basis of hard scattering operators for $e^+e^-\to$ dijets, $e^- p\to e^-$ jet, and constrained Drell-Yan, including the first two subleading orders in the amplitude level power expansion. We analyze the form of the hard, jet, and soft function contributions to the power suppressed cross section for $e^+e^-\to$ dijet event shapes, and give results for the lowest order matching to the contributing operators. These results will be useful for studies of power corrections both in fixed order and resummed perturbation theory.
description: 110 pages, many figures
Phenomenological Parameters of the Prototype Eclipsing Binaries Algol, $β$ Lyrae and W UMa
Creators: name: Tkachenko, Mariia G.
name: Andronov, Ivan L.
name: Chinarova, Lidia L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The phenomenological parameters of eclipsing binary stars, which are the prototypes of the EA, EB and EW systems are determined using the expert complex of computer programs, which realizes the NAV ("New Algol Variable") algorithm (Andronov 2010, 2012) and its possible modifications are discussed, as well as constrains for estimates of some physical parameters of the systems in a case of photometric observations only, such as the degree of eclipse, ratio of the mean surface brightnesses of the components. The half-duration of the eclipse is 0.0617(7), 0.1092(18) and 0.1015(7) for Algol, $β$ Lyrae and W UMa, respectively. The brightness ratio is 6.8$\pm$1.0, 4.9$\pm$1.0 and 1.15$\pm$0.13. These results show that the eclipses have distinct begin and end not only in EA (as generally assumed), but also in EB and EW - type systems as well. The algorithm may be applied to classification and study of the newly discovered (or poorly studied) eclipsing variables based on own observations or that obtained using photometric surveys.
description: Journal of Physical Studies, 2016, 20, N4 (in press), 10 pages, 4 figures
HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs
Creators: name: Lim, Albebson L.
name: Moos, Philip
name: Pond, Christopher D.
name: Larson, Erica C.
name: Martins, Laura J.
name: Szaniawski, Matthew A.
name: Planelles, Vicente
name: Barrows, Louis R.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu that accompanies viral production is incomplete. We have used an in vitro system to model HIV-1 infection of macrophages, and single-cell RNA sequencing (scRNA-seq) to compare the transcriptomes of uninfected cells, cells harboring pre-integration complexes (PIC), and those containing integrated provirus and making late HIV proteins. scRNA-seq can distinguish between provirus and PIC cells because their background transcriptomes vary dramatically. PIC cell transcriptomes are characterized by NFkB and AP-1 promoted transcription, while transcriptomes of cells transcribing from provirus are characterized by E2F family transcription products. We also find that the transcriptomes of PIC cells and Bystander cells (defined as cells not producing any HIV transcript and thus presumably not infected) are indistinguishable except for the presence of HIV-1 transcripts. Furthermore, the presence of pathogen alters the transcriptome of the uninfected Bystander cells, so that they are distinguishable from true control cells (cells not exposed to any pathogen). Therefore, a single cell comparison of transcriptomes from provirus and PIC cells provides a new understanding of the transcriptional changes that accompany HIV-1 integration.
The Effect of Time, Price of Stock Research and Development, and Number of Bugs on Net Revenue for Intel Corporation
Creators: name: Ozgur, Ceyhun
name: Shen, Li
name: Shen, Yiming
name: Chen, Haojie
name: Bridwell, Abby
Publisher: name: figshare
Year: 2019
Subjects: classificationCode: 350307
subject: Technology management
classificationCode: 350705
subject: Innovation management
classificationCode: 390405
subject: Educational technology and computing

description: Intel Corporation studied the effect of bugs in the revenue of the company. In this paper, we look at the factors affecting the revenue of Intel Corporation with respect to how bugs affect the revenue. By doing research on the development and number of Intel employees, we examined the effect it has on stock price, and how bugs affect this in the corporation.
An Examination of Veterans’ Diet Quality
Creators: name: Dong, Diansheng
name: Stewart, Hayden
name: Carlson, Andrea
name: Dong, Diansheng
name: Stewart, Hayden
name: Carlson, Andrea
Publisher: name: Unknown
Year: 2019
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Health Economics and Policy
subject: Veterans
subject: diet quality
subject: Healthy Eating Index (HEI)
subject: empty calories
subject: fruits
subject: vegetables,
subject: whole grains
subject: NHANES

description: Veterans represent about 7 to 8 percent of the U.S. adult population and may participate in Government programs, including healthcare and nutrition education programs administered by the U.S. Department of Veterans Affairs. Registered dietitians and other nutrition professionals work with veterans and their families (at VA healthcare facilities across the country) to promote wellness and prevent disease. In this study, we assess veterans’ diets using the Healthy Eating Index (HEI) of the U.S. Department of Agriculture and the National Cancer Institute. The HEI measures how well diets align with key Federal recommendations, and higher HEI scores are associated with a reduced risk of disease and lower healthcare costs. HEI scores are measured using data from the National Health and Nutrition Examination Survey’s (NHANES) dietary intake module. Individuals participating in this module of the survey complete two 24-hour dietary recalls on nonconsecutive days. They also provide extensive demographic and biomedical data. For the study, we pool survey records collected between 2003 and 2016. Results reveal that, similar to other Americans, veterans could improve their diet quality. Given veterans’ reported energy intake, their consumption of added sugars and solid fats is too high and their consumption of fruits, vegetables, whole grains, and dairy products too low relative to the dietary guidelines. After controlling for demographic characteristics and a general time trend, we find that veterans attained lower total HEI scores for overall diet quality than did nonveterans.
Engineering synthetic Lsm rings for applications in nanotechnology
Creators: name: Manea, Francesca
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The structural diversity of proteins makes them highly attractive as self-assembling bio-bricks or 'tectons' for the fabrication of biocompatible materials. In the current study, ring-forming Lsm proteins were exploited to construct novel nanostructures via supramolecular engineering. The Lsm family of proteins comprise the core of the ribonucleoprotein (RNP) complexes, crucial to RNA metabolism. They assemble into oligomeric rings of six to eight protein chains in vitro to generate an RNA-binding scaffold. Synthetic ring tectons composed of individual or fused Lsm sequences from S.cerevisiae were engineered so as to self assemble into simplified ring structures. My work focused on two polyprotein forms, fusions of Lsm[4+1] and Lsm[2+3]. In solution these recombinant Lsm polyproteins self-organise into robust string structures (7.5 nm x 5.0 nm), that maintain their intrinsic RNA-binding ability. Elevated levels of overlaid ring pairs are favoured at low ionic strength, indicating electrostatic mediated packing of Lsm rings. SAXS output reveals these ring pairs to be assembled in a staggered conformation rather than coaxially stacked. Using chemical modification, Lsm tectons were further fabricated into new coherent architectures. Cys residues engineered into two opposing tecton faces promoted covalent interactions between rings, generating disulfide-bonded Lsm[4+1]₄ clusters (11-12 nm) that were readily disengaged by reduction agents. This cluster coordination, resulting in organisations that are sensitive to EDTA, salt concentration and pH. A Ni²⁺-chelated Lsm[4+1]₄ cluster displayed structural similarities to its Cys-linked counterpart; this four-ringed assembly possessing an increased stability compared to Lsm[4+1]₄, although RNA-binding was compromised. In the presence of Cu²⁺ or Co²⁺ the tecton Lsm3₈ organised as ring pairs that were coaxially organised, so displaying potential as a precursor to an Lsm-based tubule. This thesis also describes crystallisation progress towards and atomic-resolution structure of the Lsm[4+1]₄ tecton. With highly pure samples, screening and optimisation across a range of conditions and crstallisation avenues allowed collection of six native datasets (at ̃ 3 Å). This data could serve to solve the first crystal structure of an Lsm polyprotein ring at high resolution. The use of Lsm rings to construct new and functional nanostructures is still in its infancy. However, this project illustrates their potential as robust and highly stable tectons, suitable for engineering endeavours. The construction of Lsm tectons into controllable higher-order superstructures, discussed in this thesis, may have future applications in RNA housing and delivery capsules or as next-generation bio-inspired nanosensors.
A review of the intuition literature relative to a recent quantitative study of the determinants of farmers’ intuition
Creators: name: Nuthall, Peter
name: Nuthall, Peter
Publisher: name: Unknown
Year: 2019
Subjects: subject: Research Methods/ Statistical Methods
subject: Intuition
subject: tacit knowledge
subject: review of intuition literature
subject: intuition variables
subject: improving intuition
subject: decision methods

description: Through a review of the literature covering the use of intuition for decision making, this article isolates the important intuition determining variables and relates them to recent quantitative intuition research. As most farm decisions are made through intuition farmers, consultants, researchers and students of farm management will find the review valuable when thinking about managerial ability. The literature reviewed is taken from both urban and rural business studies as urban based studies dominate. The search covered all journals and articles in recent decades. The summary, and the quoted quantitative research, consider the variables which can be targeted in improving intuitive skill and provides a basis for thinking about intuition and its improvement within the farming world. It is concluded the most important skill to concentrate on is improving a farmer’s self-criticism through using a decision diary in conjunction with reflection and consultation leading to improved decision understanding. But many other variables are also important and contribute.
Effects of Spatial Fluctuations in the Extra Galactic Background Light on Hard Gamma Ray Spectra
Creators: name: Kudoda, A. M.
name: Faltenbacher, A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: This study investigates the impact of the fluctuations in the extra galactic background light (EBL) on the attenuation of the hard $γ$-ray spectra of distant blazars. EBL fluctuations occur on the scales up to 100 Mpc and are caused by clustering of galaxies. The EBL photons interact with high energy $γ$-rays via the electron-positron pair production mechanism: $γ+ γ' \rightarrow e^+ + e^-$. The attenuation of $γ$-rays depends on their energy and the density of the intervening EBL photon field. Using a simple model for the evolution of the mean EBL photon density, we implement an analytical description of the EBL fluctuations. We find that the amplitudes of the EBL energy density can vary by $\pm 1\%$ as a function of environment. The EBL fluctuations lead to mild alterations of the optical depth or equivalently the transmissivity for $γ$-rays from distant blazars. Our model predicts maximum changes of $\pm 10\%$ in the $γ$-ray transmissivity. However, this translates into marginal differences in the power law slopes of currently observed $γ$-ray spectra. The slopes of deabsorbed $γ$-ray spectra differ by not more than $\pm 1\%$ if EBL fluctuations are included.
Additional file 2: of Concordance between modification of diet in renal disease, chronic kidney disease epidemiology collaboration and Cockcroft-Gault equations in patients with chronic kidney disease at St. Paulâ s hospital millennium medical college, Addis Ababa, Ethiopia
Creators: name: Hunduma Dinsa
name: Teshome Nedi
name: Alemseged Berha
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Annex III-Consent Form. (DOCX 15 kb)
Sodium houttuyfonate enhances the mono-therapy of fluconazole on oropharyngeal candidiasis (OPC) through HIF-1α/IL-17 axis by inhibiting cAMP mediated filamentation in Candida albicans-Candida glabrata dual biofilms
Creators: name: Chen, Mengli
name: Cheng, Ting
name: Xu, Chen
name: Pan, Min
name: Wu, Jiadi
name: Wang, Tianming
name: Wu, Daqiang
name: Yan, Guiming
name: Wang, Changzhong
name: Shao, Jing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Candida albicans and Candida glabrata are two common opportunistic fungi that can be co-isolated in oropharyngeal candidiasis (OPC). Hypha is a hallmark of the biofilm formation of C. albicans, indispensable for the attachment of C. glabrata, which is seldom in mycelial morphology. Increasing evidence reveals a hypoxic microenvironment in interior fungal biofilms, reminding of a fact that inflammation is usually accompanied by oxygen deprivation. As a result, it is assumed that the disaggregation of hypha-mediated hypoxia of biofilms might be a solution to alleviate OPC. Based on this hypothesis, sodium houttuyfonate (SH), a well-identified traditional herbal compound with antifungal activity, is used in combination with fluconazole (FLU), a well-informed synthesized antimycotics, to investigate their impact on filamentation in C. albicans and C. glabrata dual biofilms and the underlying mechanism of their combined treatment on OPC. The results show that compared with the single therapy, SH plus FLU can inhibit the hyphal growth in the mixed biofilms in vitro, decrease the fungal burden of oral tissues and internal organs, restore mucosal epithelial integrity and function, and reduce hypoxic microenvironment and inflammation in a mice OPC model. The possible mechanism of the combined therapy of SH plus FLU can be attributed to the regulation of HIF-1α/IL-17A axis through direct abrogation of the dual Candida biofilm formation. This study highlights the role of HIF-1α/IL-17A axis and the promising application of SH as a sensitizer of conventional antifungals in the treatment of OPC.
Cubic trihedral corner entanglement for a free scalar
Creators: name: Sierens, Lauren E. Hayward
name: Bueno, Pablo
name: Singh, Rajiv R. P.
name: Myers, Robert C.
name: Melko, Roger G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We calculate the universal contribution to the $α$-Renyi entropy from a cubic trihedral corner in the boundary of the entangling region in 3+1 dimensions for a massless free scalar. The universal number, $v_α$, is manifest as the coefficient of a scaling term that is logarithmic in the size of the entangling region. Our numerical calculations find that this universal coefficient has both larger magnitude and the opposite sign to that induced by a smooth spherical entangling boundary in 3+1 dimensions, for which there is a well-known subleading logarithmic scaling. Despite these differences, up to the uncertainty of our finite-size lattice calculations, the functional dependence of the trihedral coefficient $v_α$ on the Rényi index $α$ is indistinguishable from that for a sphere, which is known analytically for a massless free scalar. We comment on the possible source of this $α$-dependence arising from the general structure of (3+1)-dimensional conformal field theories, and suggest calculations past the free scalar which could further illuminate the general structure of the trihedral divergence in the Rényi entropy.
description: 13 pages, 6 figures
Additional file 1: of The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex
Creators: name: Verduci, Lorena
name: Ferraiuolo, Maria
name: Sacconi, Andrea
name: Ganci, Federica
name: Jlenia Vitale
name: Colombo, Teresa
name: Paci, Paola
name: Strano, Sabrina
name: Macino, Giuseppe
name: Rajewsky, Nikolaus
name: Blandino, Giovanni
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary results and figures. (DOCX 3840Â kb)