cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Abordagem da Hepatite Hipóxica no Cenário de Emergência: Protocolo de Revisão de Escopo
Creators: name: Do Nascimento, Maria Eduarda de Freitas Mesquita
name: Dias Vasconcelos, Lucas
name: Haddad, Julia Oliveira Dabien
name: Cirilo de Lucena Neto, Olival Cirilo de Lucena
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine

description: This document outlines the protocol for a scoping review researching the approach of Hypoxic Hepatitis (HH) in the emergency scenario.
Drug-eluting Stents in Premature Coronary Disease in Young People with Homozygous Familial Hypercholesterolemia and Prior Liver Transplant. A Report of Two Cases
Creators: name: SciDoc Publishers International Journal Of Cardiology And Research (IJCRR)
name: Echeverri D
name: Cabrales JR
name: Cardenas I
name: Ordonez F
Publisher: name: figshare
Year: 2017
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Lipoprotein metabolism disorders, as well as high fat diets, obesity and physical inactivity have given rise to an atherosclerotic disease epidemic worldwide. The interaction of these adverse environmental factors with genetic and acquired lipoprotein disorders predispose to an increasingly earlier development of atherosclerosis. In the United States, mortality due to coronary artery disease (CD) in middle aged people has decreased by 31% during the last decade. However, atherosclerotic cardiovascular disease continues to be the most frequent cause of death, both in men and women. The general mortality rate due to cardiovascular diseases is 235.5 per 100,000 population and CD only caused 1 out of 6 deaths in the United States in 2010
Five new bioactive compounds from Chenopodium ambrosioides
Creators: name: Song, Kun
name: Zhang, Jian
name: Zhang, Peng
name: Wang, Hong-Qing
name: Liu, Chao
name: Li, Bao-Ming
name: Kang, Jie
name: Chen, Ruo-Yun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Biochemistry

description: Five new bioactive compounds, chenopodiumamines A–D (1–4) and chenopodiumoside A (5), were isolated from the ethanol extract of Chenopodium ambrosioides. The structures of these compounds were elucidated by various spectroscopic means (UV, IR, HR-ESI-MS, 1D and 2D NMR). Compounds 1–3 had moderate antioxidant and anti-inflammatory activities.
Open Science vs. Intellectual Property in a Democratic Order
Creators: name: Caso, Roberto
Publisher: name: Zenodo
Year: 2020
Subjects: Open Science
Open Access
Closed Science
Research assessment
Science evaluation system
Commodification
Intellectual property
Copyright law

description: The evaluation of scientific research is based on data protected by secrecy and intellectual property (e.g., Elsevier Scopus or Clarivate Web of Science). While science has progressed thanks to public dialogue, the current evaluation system is centered on private control of information. This represents a fundamental shift from democratic to authoritarian science. Open Science may confront this change only if it is accepted as the heir, in the digital age, of the values and principles that public and democratic science has traditionally fostered in the age of printing, thus becoming the guardian of a democratic society.
Expression of Tropomyosin 2 Gene Isoforms in Human Cardiac Tissue
Creators: name: SciDoc Publishers International Journal Of Cardiology And Research (IJCRR)
name: Syamalima Dube
name: Santhi Yalamanchili
name: Lachant, Joseph
name: Abbott, Lynn
name: Benz, Patricia
name: Dube, Dipak K
name: Poiesz BJ
Publisher: name: figshare
Year: 2017
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Previous studies have shown that although the transcript levels of TPM1α and TPM1k are expressed in human hearts in comparable levels, the level of TPM1α protein is ~90%. The proteins of TPM1κ and TPM2α are about 5% of the total sarcomeric TM. The TPM2 gene is known to generate three alternatively spliced isoforms, which are designated as TPM2α, TPM2β, and TPM2γ. The expression level of TPM2β and TPM2γ in human hearts is unknown. Using a series of primers pairs and probes for RNA PCR, we found that both TPM2α and β but not γ were expressed in fetal and adult heart tissue, with about the same amounts of each isoform in fetal hearts and more β than α in adult hearts. Four new isoforms of TPM2 RNA were identified (TPM2δ - η). Most of these were present in very small amounts in both the fetal and adult hearts with the exception of TPM2ξ, which was present at about 40% of the level of TPM2α in adult heart tissue. Western blot analyses using a series of anti-tropomyosin antibodies indicate that TPM2 protein is present in both fetal and adult hearts at about the same levels as TPM1κ and much less than TPM1α. We are unsure about the expression of TPM2δ, TPM2ζ, and TPM2η proteins in fetal and adult human hearts. The exact function of these new TPM2 isoforms in heart and their role(s) in cardiac disease remain to be elucidated.
Idiopathic Giant Cell Myocarditis - A Case Report
Creators: name: SciDoc Publishers International Journal Of Cardiology And Research (IJCRR)
name: Ratheesh P T
name: Priyathap
name: Shirleyvasu
Publisher: name: figshare
Year: 2017
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Sudden cardiac death is an unexpected death from cardiac causes; early after the symptom onset or even without any symptoms [1]. This case report is on a non-atherosclerotic cause of sudden cardiac death. An young adult collapsed and died while at work. Autopsy was done in view of an unnatural death and ruling out various unnatural causes. Post mortem revealed morphological evidence of cardiac disease. On further evaluation it turned out to be a distinctive form of myocarditis. Myocarditis is the inflammation of heart which results in myocardial injury. The case report aims at discussion on clinical presentation, gross and histological findings of idiopathic giant cells myocarditis.. This case report highlights one such case, where reporting rare entities get mandated in the light of clear cut histological diagnosis after ruling out other causes of sudden death.
Proteomic profile of serum of pregnant women carring a fetus with Down syndrome using nano uplc Q-tof ms/ms technology
Creators: name: Uriarte, Graciela Arelí López
name: Flores, Carlos Horacio Burciaga
name: Cruz, Víctor Manuel Torres De La
name: Aguado, María Magdalena Medina
name: Puente, Viviana Maricela Gómez
name: Gutiérrez, Liliana Nayeli Romero
name: Villarreal, Laura Elia Martínez De
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Introduction: Prenatal diagnosis of Down syndrome (DS) is based on the calculated risk of maternal age, biochemical and ultrasonographic markers and recently by cfDNA. Differences in proteomic profiles may give an opportunity to find new biomarkers. Objective: Characterize proteome of serum of mothers carrying DS fetus. Material and methods: Blood serum samples of three groups of women were obtained, (a) 10 non-pregnant, (b) 10 pregnant with healthy fetus by ultrasound evaluation, (c) nine pregnant with DS fetus. Sample preparation was as follows: Albumin/IgG depletion, desalting, and trypsin digestion; the process was performed in nanoUPLC MS/MS. Data analysis was made with Mass Lynx 4.1 and ProteinLynx Global Server 3.0, peptide and protein recognition by MASCOT algorithm and UNIPROT-Swissprot database. Results: Each group showed different protein profiles. Some proteins were shared between groups. Only sera from pregnant women showed proteins related to immune and clot pathways. Mothers with DS fetus had 42 specific proteins. Conclusions: We found a different serum protein profile in mothers carrying DS fetuses that do not reflect expression of genes in the extra chromosome. Further studies will be necessary to establish the role of these proteins in aneuploid fetus and analyze their possible use as potential biomarkers.
A new apotirucallane-type triterpenoid from Atalantia buxifolia
Creators: name: Guo, Zhi-Kai
name: Yang, Tao
name: Cai, Cai-Hong
name: Dong, Wen-Hua
name: Gai, Cui-Juan
name: Yuan, Jing-Zhe
name: Mei, Wen-li
name: Dai, Hao-fu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Information and Computing Sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: A new triterpenoid (1) with apotirucallane skeleton was isolated from the ethanol extract of the roots of Atalantia buxifolia (Poir.) Oliv. The complete structural assignment of the new compound was elucidated by a combination of 1D, 2D NMR (HMQC, HMBC, COSY, and NOESY), and HR-ESI-MS analysis. Moreover, this new compound was evaluated in vitro for its cytotoxic, antimicrobial and enzymes inhibitory activities.
Samples and methods. Zircon O- and Hf-isotope constraints on the genesis and tectonic significance of Permian magmatism in Patagonia
Creators: name: Castillo, Paula
name: C. Mark Fanning
name: Pankhurst, Robert J.
name: Hervé, Francisco
name: Rapela, Carlos W.
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Samples and methods.
A Rare Case of Situs Inversus with Mesocardia
Creators: name: SciDoc Publishers International Journal Of Cardiology And Research (IJCRR)
name: Sajith J S
name: Gobbur R H
name: Koti P
name: Patil S V
Publisher: name: figshare
Year: 2017
Subjects: subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: A ten year old male child having congenital heart disease admitted with recurrent history of respiratory infection. ECHO cardioraphy showed Mesocardia, congenitally corrected TGA, bidirectional VSD and severe pulmonary valve stenosis.On sonographic evaluation showed intra-abdominal mirror imaging of all the solid organs and vessels which was suggestive of a rare presentation of Sinus inverses with Mesocardia. Corrective surgery as pulmonary valve balloon dilation or valvuloplasty and vestricular septal repair has to be done to the child for better morbidity and reducing the mortality risk. This anomaly complicates the diagnosis and management of acute abdominal conditions like appendicitis, diverticulitis and biliary colic.
Computation of glacier-wide mass balance: evaluating the potential of the linear mass balance model
Creators: name: Huss, Matthias
Publisher: name: GLAMOS - Glacier Monitoring Switzerland
Year: 2020

description: The present report provides an in-depth evaluation of the so-called linear mass balance model using GLAMOS data. The aim is to shed light on the potential of this approach but also to emphasize the related drawbacks and problems.The report is provided in .pdf format.
title: 1962-1963_WURSTEISEN Georges_Un musée de l'homme primitif
Creators: name: Wursteisen, Georges
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Diplôme d'architecte

description: Prix du meilleur diplôme décerné par la SADG.
Two new triterpenoid saponins from the aerial parts of Anemone taipaiensis
Creators: name: Li, Hui
name: Wang, Xiao-Yang
name: Wang, Xia-Yin
name: Hua, Dong
name: Liu, Yang
name: Tang, Hai-Feng
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: Phytochemical study on the aerial parts of Anemone taipaiensis for the first time led to the isolation of two new oleanane-type triterpenoid saponins 1 and 2, together with four known saponins (3–6). Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Saponins 2–4 exhibited cytotoxicity against human glioblastoma U251MG cell line with IC50 values ranging from 1.56 to 80.62 μM.
European and Russian physician awareness of best management approaches for infections due to antibiotic-resistant Gram-negative bacteria
Creators: name: Paurus Irani
name: Tehseen Salimi
name: Epstein, Robert
name: Leone-Perkins, Megan
name: Aubert, Ronald
name: Khalid, Mona
name: Epstein, Emma
name: J. Russell Teagarden
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objectives: The rapid spread of infections due to antibiotic-resistant, Gram-negative bacteria in Europe and surrounding regions requires a heightened level of awareness among physicians within their practice settings. Methods: We surveyed 800 physicians who treat these infections across France, Germany, Spain, Italy, and Russia to assess their awareness of best management approaches. Results: We found that more than two-thirds do not consider themselves highly aware of best management practices. The respondents are facing these resistant infections as evidenced by the antibiotics they report using and their stated interest in newer agents. Respondents indicated that precious time is lost waiting for culture results, but also said they will need more information about accuracy, use, and costs for adopting rapid molecular testing. Conclusions: The survey further identified the need for treatment guidelines and clinical decision support tools that can be applied at the bedside.
Diterpenes and lignans from Viburnum odoratissimum var. odoratissimum
Creators: name: Li, Feng-Jie
name: Yu, Jin-Hai
name: Wang, Guo-Cai
name: Zhang, Hua
name: Yue, Jian-Min
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Cell Biology
subject: Biochemistry

description: A new diterpenoid, dehydrovibsanin G (1), a new lignan, (+)-9′-O-senecioyllariciresinol (2), and six known compounds (3–8) were isolated from the branches and leaves of Viburnum odoratissimum var. odoratissimum. The structures of these compounds were elucidated by analysis of spectroscopic data. Both new compounds showed moderate inhibitory activity against human A431 and T47D tumor cell lines.
Nitrification, denitrification, and dephosphatation capability of activated sludge during co-treatment of intermediate-age landfill leachates with municipal wastewater
Creators: name: S. Fudala-Ksiazek
name: E. Kulbat
name: A. Luczkiewicz
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: This study focuses on the possible use and efficacy of the co-treatment of landfill leachate (intermediate-age) with municipal wastewater. The nitrification, denitrification, and dephosphatation capability of activated sludge acclimated with a mixture of raw municipal wastewater (RWW) with gradually increasing amounts of raw landfill leachate (RLL) (from 0.5 to 5% v/v) were tested. Biochemical tests were conducted simultaneously in batch reactors (BRs). According to the obtained data, the ammonia utilization rate (AUR) was 3.68 g N/(kg volatile suspended solids (VSS)·h) for RWW, and it increased to 5.78 g N/(kg VSS·h) with the addition of 5% RLL. The nitrate utilization rate under anoxic conditions (NURAX) remained at a comparable level of 1.55–1.98 g N/(kg VSS·h). During the anoxic phase, both nitrate utilization and phosphorus uptake occurred, suggesting that denitrifying phosphorus-accumulating organisms (DPAOs) utilized N–NO3. With the addition of RLL, the rates of anoxic and aerobic phosphate uptake (PURAX and PURAE) and phosphate release rate (PRR) decreased. The PRR was likely negatively influenced by high N–NO3 concentrations but not completely inhibited due to the availability of a biodegradable fraction of chemical oxygen demand (COD). Thus, monitoring the NH4–N load in wastewater treatment plant influent before co-treatment is more informative than that using hydraulic-based criteria. Abbreviations:σ – standard deviation; AUR – ammonia utilization rate; DPAO – denitrifying phosphorus-accumulating organisms; MLVSS – mixed liquor volatile suspended solids content; MSW – municipal solid waste; NURAE – nitrate production rate under aerobic conditions; NURAX – nitrate utilization rate under anoxic conditions; PAO – phosphorus-accumulating organisms; PRR – phosphate release rate under anaerobic conditions; PURAX – phosphate uptake rate under anoxic conditions; PURAE – phosphate uptake rate under aerobic conditions; RLL – raw landfill leachates; RM0.5 – raw mixture of RWW with 0.5% (vol.) of RLL; RM3 – raw mixture of RWW with 3% (vol.) of RLL; RM5 – raw mixture of RWW with 5% (vol.) of RLL; RWW – wastewater; VFA – volatile fatty acids; WWTP – wastewater treatment plant
Joint FORCE11 & COPE Research Data Publishing Ethics Working Group Policy Templates
Creators: name: Lowenberg, Daniella
name: Puebla, Iratxe
name: FORCE11 Research Data Publishing Ethics WG
Publisher: name: Zenodo
Year: 2022

description: The FORCE11 Research Data Publishing Ethics Working Group, in collaboration with Committee on Publication Ethics (COPE), has developed policy template text for journals & publishers as well as repositories, in alignment with our Joint FORCE11 & COPE Research Data Publishing Ethics Working Group Recommendations.
Healthy Mums and Babies (HUMBA) trial 12 month follow up protocol
Creators: name: Mckinlay, Chris
name: Karaponi Okesene-Gafa
name: Thompson, John
name: Wall, Clare
name: Bradford, Billie
name: Rush, Elaine
name: McCowan, Megan
name: Minglan Li
name: Rennae Tylor
name: Crowther, Caroline
name: McCowan, Lesley
Publisher: name: The University of Auckland
Year: 2017
Subjects: subject: 111401 Foetal Development and Medicine
subject: FOS: Clinical medicine
subject: 111402 Obstetrics and Gynaecology
subject: 111403 Paediatrics
subject: 111717 Primary Health Care
subject: FOS: Health sciences
subject: 111104 Public Nutrition Intervention
subject: 111715 Pacific Peoples Health
subject: 111713 Maori Health
subject: Health Care

description: This is the protocol for a follow-up study of 1-year-old children and their mothers from the HUMBA Demonstration Trial, two by two factorial randomised controlled trial of a dietary intervention versus routine dietary advice, and probiotics versus placebo (double blind) in obese pregnant women. The primary objectives of this study are to determine if at 1 year post expected delivery date whether treatment of obese pregnant women with probiotics versus placebo, and a dietary intervention versus routine dietary advice: 1) For the infant reduces risk factors for later obesity and cardio-metabolic disease, including large body size, rapid growth, excess adiposity, high food avidity (appetite), excess nutrient intake, aortic intima-medial thickening and low physical activity; and improves neurodevelopmental progress; 2) For the mother reduces post-partum weight retention and increases healthy nutritional and physical activity behaviours, and measures of mental health and quality of life.
Solid-Solution CrCoCuFeNi High-Entropy Alloy Thin Films Synthesized by Sputter Deposition
Creators: name: An, Zhinan
name: Jia, Haoling
name: Wu, Yueying
name: Rack, Philip D.
name: D. Patchen, Allan
name: Liu, Yuzi
name: Ren, Yang
name: Li, Nan
name: K. Liaw, Peter
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Virology
subject: Biological Sciences
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Medicine
subject: Physics
subject: Engineering
subject: Biophysics

description: The concept of high configurational entropy requires that the high-entropy alloys (HEAs) yield single-phase solid solutions. However, phase separations are quite common in bulk HEAs. A five-element alloy, CrCoCuFeNi, was deposited via radio frequency magnetron sputtering and confirmed to be a single-phase solid solution through the high-energy synchrotron X-ray diffraction, energy-dispersive spectroscopy, wavelength-dispersive spectroscopy, and transmission electron microscopy. The formation of the solid-solution phase is presumed to be due to the high cooling rate of the sputter-deposition process.
Pandemic, Higher Education, and a Developing Country: How Teachers and Students Adapt to Emergency Remote Education
Creators: name: Garcia, Manuel
Publisher: name: figshare
Year: 2022
Subjects: Education

description: The sudden transition to emergency remote education (ERE) caused by the pandemic has been a highly complex undertaking for teachers and students alike. For developing countries, such a disruption only aggravates the preexisting global education crisis and influences the sector in unprecedented ways. Thus, we explored how teachers and students from higher education in a developing country adapt to ERE during the pandemic. Specifically, we attempted to identify the common challenges faced by teachers and students and their coping strategies to handle pandemic-induced stress. To this end, we conducted a comparative cross-sectional study from October to November 2021 with 78 teachers and 94 students from a higher education institution in Manila, Philippines. Our results show that while self-regulation is the greatest challenge among students, it is the conduciveness of the home environment for teachers. Interestingly, although teachers and students have varying concerns, both groups rely on acceptance, humor, and positive reframing as their coping strategies. By painting a holistic picture of the challenges and coping strategies of both teachers and students, education policymakers and administrators can make an informed decision on how to best continue ERE and prepare in advance for the resumption of school in the new normal
ADVANCES IN ASTHMA MANAGEMENT IN PEDIATRICS
Creators: name: Hani Abdullah Alhashmi, Fatamh Ali Alsharif, Abdulrahman Ali Walibi, Atheer Mansour Alatawi, Haitham Rasheed Alhaeti, Nojoud Mohammed Alfarhan, Mishaal Hisham Rayees, Sarah Naseemuddin A Khan, Misfer Hassan Misfer Alessa, Abdullah Saeed Abdullah Alshehri, Zahra Ali Abu Alrehi, Amal Habib Al Suliman, Khadija Ali Alkhamis, Salma Ebrahim Alquhaidan
Publisher: name: Zenodo
Year: 2024

description: Asthma is a common condition affecting more than 300 million people around with an incidence rate of 5.3% in children. Asthma requires to be differentiated from other diseases like cystic fibrosis and bronchiectasis. As children have different bodily constitutions compared to adults, the guidelines for pharmacological therapy vary. The use of emerging therapy options eases the burden of emergency department visits. Thus, reviewing the latest advancements and therapy guidelines helps to reduce the associated morbidity and mortality.

Aim of the study: to review the latest methodology for the management of asthma in pediatric patients

Materials and methods: This review is a comprehensive search of PUBMED from the year 2014 to 2024.

Conclusion:Asthma is a disease with a multifactorial etiology, therefore there is a need for a multi-disciplinarian approach to reduce future morbidities in pediatric patients. There is a need for the establishment of recommendations for SMART therapy in children younger than 4 years and further study into the use of biologics.

Keywords: asthma; management; SMART therapy; biologics
Electronic adherence monitoring device performance and patient acceptability: a randomized control trial
Creators: name: Chan, Amy Hai Yan
name: Stewart, Alistair William
name: Harrison, Jeff
name: Black, Peter Nigel
name: Mitchell, Edwin Arthur
name: Foster, Juliet Michelle
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Background: To investigate the performance and patient acceptability of an inhaler electronic monitoring device in a real-world childhood asthma population. Methods: Children 6 to 15 years presenting with asthma to the hospital emergency department and prescribed inhaled corticosteroids were included. Participants were randomized to receive a device with reminder features enabled or disabled for use with their preventer. Device quality control tests were conducted. Questionnaires on device acceptability, utility and ergonomics were completed at six months. Results: A total of 1306 quality control tests were conducted; 84% passed pre-issue and 87% return testing. The most common failure reason was actuation under-recording. Acceptability scores were high, with higher scores in the reminder than non-reminder group (median, 5th-95th percentile: 4.1, 3.1–5.0 versus 3.7, 2.3–4.8; p 90%) rated the device easy to use. Feedback was positive across five themes: device acceptability, ringtone acceptability, suggestions for improvement, effect on medication use, and effect on asthma control. Conclusions: This study investigates electronic monitoring device performance and acceptability in children using quantitative and qualitative measures. Results indicate satisfactory reliability, although failure rates of 13–16% indicate the importance of quality control. Favorable acceptability ratings support the use of these devices in children.
MAPA - TRAÇOS DE PERSONALIDADE DO MOTORISTA
Creators: name: Costa, Patricia Luíza
name: Bernardino, Geraldir Eustáquio
Publisher: name: figshare
Year: 2022
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 170201 Computer Perception, Memory and Attention
subject: 170202 Decision Making

description: Mapeamento do comportamento do motorista ao trânsito.
Patient-reported outcome after total hip arthroplasty: comparison between lateral and posterior approach
Creators: name: Rosenlund, Signe
name: Broeng, Leif
name: Holsgaard-Larsen, Anders
name: Jensen, Carsten
name: Overgaard, Søren
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background and purpose — Criticism of the lateral approach (LA) for hip arthroplasty is mainly based on the risk of poor patient-reported outcomes compared to the posterior approach (PA). However, there have been no controlled studies comparing patient-reported outcomes between them. In this randomized controlled trial, we tested the hypothesis that patient-reported outcomes are better in patients who have undergone total hip arthroplasty (THA) with PA than in those who have undergone THA with LA, 12 months postoperatively. Patients and methods — 80 patients with hip osteoarthritis (mean age 61 years) were randomized to THA using PA or the modified direct LA. We recorded outcome measures preoperatively and 3, 6, and 12 months postoperatively using the Hip Disability and Osteoarthritis Outcome Score–Physical Function Short Form (HOOS-PS) as the primary outcome. Secondary outcomes were HOOS-Pain, HOOS-Quality-Of-Life, EQ-5D, UCLA Activity Score, and limping. Results — We found no statistically significant difference in the improvements in HOOS-PS between the treatment groups at 12-month follow-up. All secondary outcomes showed similar results except for limping, where PA patients improved significantly more than LA patients. Interpretation — Contrary to our hypothesis, patients treated with PA did not improve more than patients treated with LA regarding physical function, pain, physical activity, and quality of life 12 months postoperatively. However, limping was more pronounced in the LA patients.
A Simulation Study on the Efficacy of Advanced Belt Restraints to Mitigate the Effects of Obesity for Rear-Seat Occupant Protection in Frontal Crashes
Creators: name: Wang, Yulong
name: Bai, Zhonghao
name: Cao, Libo
name: P. Reed, Matthew
name: Fischer, Kurt
name: Adler, Angelo
name: Hu, Jingwen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Earth and Environmental Sciences
Medicine

description: Objective: Recent field data analyses have shown that the safety advantages of rear seats relative to the front seats have decreased in newer vehicles. Separately, the risks of certain injuries have been found to be higher for obese occupants. The objective of this study is to investigate the effects of advanced belt features on the protection of rear-seat occupants with a range of body mass index (BMI) in frontal crashes.Methods: Whole-body finite element human models with 4 BMI levels (25, 30, 35, and 40 kg/m2) developed previously were used in this study. A total of 52 frontal crash simulations were conducted, including 4 simulations with a standard rear-seat, 3-point belt and 48 simulations with advanced belt features. The parameters varied in the simulations included BMI, load limit, anchor pretensioner, and lap belt routing relative to the pelvis. The injury measurements analyzed in this study included head and hip excursions, normalized chest deflection, and torso angle (defined as the angle between the hip–shoulder line and the vertical direction). Analyses of covariance were used to test the significance (P <.05) of the results.Results: Higher BMI was associated with greater head and hip excursions and larger normalized chest deflection. Higher belt routing increased the hip excursion and torso angle, which indicates a higher submarining risk, whereas the anchor pretensioner reduced hip excursion and torso angle. Lower load limits decreased the normalized chest deflection but increased the head excursion. Normalized chest deflection had a positive correlation with maximum torso angle. Occupants with higher BMI have to use higher load limits to reach head excursions similar to those in lower BMI occupants.Discussion and Conclusion: The simulation results suggest that optimizing load limiter and adding pretensioner(s) can reduce injury risks associated with obesity, but conflicting effects on head and chest injuries were observed. This study demonstrated the feasibility and importance of using human models to investigate protection for occupants with various BMI levels. A seat belt system capable of adapting to occupant size and body shape will improve protection for obese occupants in rear seats.
Non-response to sad mood induction: implications for emotion research
Creators: name: Rottenberg, Jonathan
name: Kovacs, Maria
name: Yaroslavsky, Ilya
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Molecular Biology
subject: Neuroscience
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Experimental induction of sad mood states is a mainstay of laboratory research on affect and cognition, mood regulation, and mood disorders. Typically, the success of such mood manipulations is reported as a statistically significant pre- to post-induction change in the self-rated intensity of the target affect. The present commentary was motivated by an unexpected finding in one of our studies concerning the response rate to a well-validated sad mood induction. Using the customary statistical approach, we found a significant mean increase in self-rated sadness intensity with a moderate effect size, verifying the “success” of the mood induction. However, that “success” masked that, between one-fifth and about one-third of our samples (adolescents who had histories of childhood-onset major depressive disorder and healthy controls) reported absolutely no sadness in response to the mood induction procedure. We consider implications of our experience for emotion research by (1) commenting upon the typically overlooked phenomenon of nonresponse, (2) suggesting changes in reporting practices regarding mood induction success, and (3) outlining future directions to help scientists determine why some subjects do not respond to experimental mood induction.
European and Russian physician awareness of best management approaches for infections due to antibiotic-resistant gram-negative bacteria
Creators: name: Paurus Irani
name: Tehseen Salimi
name: Epstein, Robert
name: Leone-Perkins, Megan
name: Aubert, Ronald
name: Khalid, Mona
name: Epstein, Emma
name: J. Russell Teagarden
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objectives: The rapid spread of infections due to antibiotic-resistant, Gram-negative bacteria in Europe and surrounding regions requires a heightened level of awareness among physicians within their practice settings. Methods: We surveyed 800 physicians who treat these infections across France, Germany, Spain, Italy, and Russia to assess their awareness of best management approaches. Results: We found that more than two-thirds do not consider themselves highly aware of best management practices. The respondents are facing these resistant infections as evidenced by the antibiotics they report using and their stated interest in newer agents. Respondents indicated that precious time is lost waiting for culture results, but also said they will need more information about accuracy, use, and costs for adopting rapid molecular testing. Conclusions: The survey further identified the need for treatment guidelines and clinical decision support tools that can be applied at the bedside.
MAPA- PERFIL TURISTA
Creators: name: Costa, Patricia Luíza
name: Bernardino, Geraldir Eustáquio
Publisher: name: figshare
Year: 2022
Subjects: subject: 150501 Consumer-Oriented Product or Service Development
subject: FOS: Economics and business

description: Mapeamento do perfil do turista, com vistas a auxiliar na gestão do negócio do turismo no país.
Increased risk of early and medium-term revision after post-fracture total knee arthroplasty
Creators: name: El-Galaly, Anders
name: Haldrup, Steffen
name: Pedersen, Alma Becic
name: Kappel, Andreas
name: Jensen, Michael Ulrich
name: Nielsen, Poul Torben
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology

description: Background and purpose — Total knee arthroplasty (TKA) due to posttraumatic fracture osteoarthritis (PTFA) may be associated with inferior prosthesis survival. This study is the first registry-based study solely addressing this issue. Both indications and predictors for revision were identified. Patients and methods — 52,518 primary TKAs performed between 1997 and 2013 were retrieved from the Danish Knee Arthroplasty Register (DKR). 1,421 TKAs were inserted due to PTFA and 51,097 due to primary osteoarthritis (OA). Short-term (< 1 year), medium-term (1–5 years), and long-term (> 5 years) implant survival were analyzed using Kaplan-Meier analysis and Cox regression after age stratification (< 50, 50–70, and >70 years). In addition, indications for revision and characteristics of TKA patients with subsequent revision were determined. Results — During the first 5 years, TKAs inserted due to PTFA had a higher risk of revision than OA (with adjusted hazard ratio ranging from 1.5 to 2.4 between age categories). After 5 years, no significant differences in the risk of revision were seen between the groups. Infection and aseptic loosening were the most common causes of revision in both groups, but TKA instability was a more frequent indication for revision in the PTFA group. In both groups, the revision rates were higher with younger age and extended duration of primary surgery. Interpretation — We found an increased risk of early and medium-term revision of TKAs inserted due to previous fractures in the distal femur and/or proximal tibia. Predictors of revision such as age <50 years and extended duration of primary surgery were identified, and revision due to instability occurred more frequently in TKAs performed due to previous fractures.
Outcomes and Recommendations. Maximising Equity in Open and Responsible Research
Creators: name: Cole, Nicki Lisa
name: Reichmann, Stefan
name: Ross-Hellauer, Tony
Publisher: name: Zenodo
Year: 2022
Subjects: Open Science
Responsible Research and Innovation
onmerritfinale
Recommendations

description: The presentation discusses the recommendations resulting from the research work in ON-MERRIT. The recommendations, titled "Global Thinking. ON-MERRIT recommendations for maximising equity in open and responsible research", identify four areas of intervention: Resource-intensity of Open Research; Article-processing charges and the stratification of Open Access publishing; Societal inclusion in research and policy-making, and Reform of reward and recognition.
The accuracy and precision of radiostereometric analysis in upper limb arthroplasty
Creators: name: Brinke, Bart Ten
name: Beumer, Annechien
name: Koenraadt, Koen L M
name: Eygendaal, Denise
name: Kraan, Gerald A
name: Mathijssen, Nina M C
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Background and purpose — Radiostereometric analysis (RSA) is an accurate method for measurement of early migration of implants. Since a relation has been shown between early migration and future loosening of total knee and hip prostheses, RSA plays an important role in the development and evaluation of prostheses. However, there have been few RSA studies of the upper limb, and the value of RSA of the upper limb is not yet clear. We therefore performed a systematic review to investigate the accuracy and precision of RSA of the upper limb. Patients and methods — PRISMA guidelines were followed and the protocol for this review was published online at PROSPERO under registration number CRD42016042014. A systematic search of the literature was performed in the databases Embase, Medline, Cochrane, Web of Science, Scopus, Cinahl, and Google Scholar on April 25, 2015 based on the keywords radiostereometric analysis, shoulder prosthesis, elbow prosthesis, wrist prosthesis, trapeziometacarpal joint prosthesis, humerus, ulna, radius, carpus. Articles concerning RSA for the analysis of early migration of prostheses of the upper limb were included. Quality assessment was performed using the MINORS score, Downs and Black checklist, and the ISO RSA Results — 23 studies were included. Precision values were in the 0.06–0.88 mm and 0.05–10.7° range for the shoulder, the 0.05–0.34 mm and 0.16–0.76° range for the elbow, and the 0.16–1.83 mm and 11–124° range for the TMC joint. Accuracy data from marker- and model-based RSA were not reported in the studies included. Interpretation — RSA is a highly precise method for measurement of early migration of orthopedic implants in the upper limb. However, the precision of rotation measurement is poor in some components. Challenges with RSA in the upper limb include the symmetrical shape of prostheses and the limited size of surrounding bone, leading to over-projection of the markers by the prosthesis. We recommend higher adherence to RSA guidelines and encourage investigators to publish long-term follow-up RSA studies.
Diffusion-weighted magnetic resonance imaging of rectal cancer: tumour volume and perfusion fraction predict chemoradiotherapy response and survival
Creators: name: Kine Mari Bakke
name: Hole, Knut Håkon
name: Dueland, Svein
name: Grøholt, Krystyna Kotanska
name: Flatmark, Kjersti
name: Ree, Anne Hansen
name: Seierstad, Therese
name: Redalen, Kathrine Røe
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: Plant Biology

description: Background: In locally advanced rectal cancer (LARC), responses to preoperative treatment are highly heterogeneous and more accurate diagnostics are likely to enable more individualised treatment approaches with improved responses. We investigated the potential of diffusion-weighted magnetic resonance imaging (DW MRI), with quantification of the apparent diffusion coefficient (ADC) and perfusion fraction (F), as well as volumetry from T2-weighted (T2W) MRI, for prediction of therapeutic outcome. Material and methods: In 27 LARC patients receiving neoadjuvant chemotherapy (NACT) before chemoradiotherapy (CRT), T2W- and DW MRI were obtained before and after NACT. Tumour volumes were delineated in T2W MRI and ADCs and Fs were estimated from DW MRI using a simplified approach to the intravoxel incoherent motion (IVIM) model. Mean tumour values and histogram analysis of whole-tumour heterogeneity were correlated with histopathologic tumour regression grade (TRG) and 5-year progression-free survival (PFS). Results: At baseline, high tumour F predicted good tumour response (TRG1-2) (AUC = 0.79, p = 0.01), with a sensitivity of 69% and a specificity of 100%. The combination of F and tumour volume (Fpre/Vpre) gave the highest prediction of poor tumour response (AUC = 0.93, p p p Conclusions: The MRI parameter F/V at baseline was a remarkably strong predictor of both histopathologic tumour response and 5-year PFS in patients with LARC.
Results on "Innovation and Industry"
Creators: name: Fessl, Angela
name: Maitz, Katharina
name: Jahn, Najko
Publisher: name: Zenodo
Year: 2022
Subjects: industry
open science
patents
onmerritfinale

description: The presentation, delivered at the ON-MERRIT final event "Ensuring Equity in Open Science" on 22 March 2022, explored the results of the research on the uptake of RRI and Open Science outputs in SMEs and industry and their readiness to exploit FAIR data resources and the presence of open science resources (literature, data, and software) cited in patents literature.
Results on "Policy Making and Societal Actors"
Creators: name: Wieser, Bernhard
name: Reichmann, Stefan
name: Correia, Antonia
name: Rodrigues, Eloy
name: Principe, Pedro
name: Cole, Nicki Lisa
name: Ross-Hellauer, Tony
Publisher: name: Zenodo
Year: 2022
Subjects: Policy making
societal actors
open science
onmerritfinale

description: The presentation, delivered during the ON-MERRIT final event "Ensuring Equity in Open Science" on 22 March 2022, presents the results of the research strand investigating the role of Open Access and Open Science resources and public engagement in policy-making, to help understand Matthew effects within policy-making and provide evidence to mitigate these effects.
Functional image-guided dose escalation in gliomas using of state-of-the-art photon vs. proton therapy
Creators: name: Holm, Anne Ivalu Sander
name: Petersen, Jørgen Breede Baltzer
name: Muren, Ludvig Paul
name: Seiersen, Klaus
name: Borghammer, Per
name: Lukacova, Slávka
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background: Recurrences of glioma are usually local, suggesting the need for higher tumor dose. We investigated the boundaries for dose escalation of an 18F-fluoro-ethyl-tyrosine positron emission tomography defined target by intensity-modulated photon therapy (IMRT), volumetric modulated arc therapy (VMAT) and intensity-modulated proton therapy (IMPT). Materials and methods: Standard dose (60 Gy) and dose-escalated plans were calculated for seven patients using IMRT, VMAT and IMPT. The achieved boost dose, the dose to the organs at risk (OAR), the dose homogeneity (defined as overdose volume, ODV) and the ratio of the 30 Gy isodose curve and the boost volume (R30) were compared. The risk of radionecrosis was estimated using the ratio of the dose volume histograms of the brain (range 30–60 Gy). Results: The mean boost dose was 77.1 Gy for IMRT, 79.2 Gy for VMAT and 85.1 GyE for IMPT. Compared with the standard plan, the ODV was unchanged and the R30 increased (17%) for IMRT. For VMAT, the ODV decreased (7%) and the R30 was unchanged whereas IMPT substantially decreased ODV (61%), R30 (22%), OAR doses as well as the risk of radionecrosis. Conclusions: Dose escalation can be achieved with IMRT, VMAT and IMPT while respecting normal tissue constraints, yet with IMPT being most favorable.