cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
RNA Binding Protein HuR Regulates the Expression of Bcl-xL
Creators: name: Durie, Danielle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: RNA binding protein
HuR
Bcl-xL
translation
IRES
Apoptosis
mitochondria

description: The RNA-binding protein HuR controls key cellular processes by binding target mRNAs and regulating them at various post-transcriptional levels. HuR can function as an Internal Ribosome Entry Site (IRES) trans-acting factor that regulates the IRES-mediated translation of XIAP. Since XIAP and Bcl-xL expression was reported to be co-regulated, we investigated whether HuR is also a regulat or of Bcl-xL expression. We found that HuR binds the 3’end of the Bcl-xL 5’UTR in-vitro. In U2OS cells, we showed that loss of HuR by siRNA significantly increased Bcl-xL protein expression while Bcl-2 and Mcl-1 levels remained unchanged. We found that the HuR-dependent Bcl-xL increase was through translation, shown by polysome profiling. Possible transcriptional, stability and splicing changes were eliminated. At the physiological level HuR levels did not impact cell survival but altered mitochondrial morphology, partially through Bcl-xL. Thus, HuR may be involved in maintaining proper mitochondrial function by controlling Bcl-xL expression.
Influence of Feeding Ecology on Mercury Accumulation in Turtles and Fish of the Rideau Canal, Ontario, Canada
Creators: name: Chateauvert, Julie L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013

description: Pollution is a major cause of biodiversity declines worldwide. Therefore, understanding exposure and uptake mechanisms for contaminants such as mercury (Hg) is a crucial step in our efforts to understand the causes of species decline. I investigated the influence of dietary reliance on the benthic food chain, and the influence of the proportion of zebra mussels in the diet, on the accumulation of Hg in freshwater fish and turtle species. I collected turtle blood samples and fish muscle samples in 2012 and analyzed these tissue samples for carbon and nitrogen isotope ratios (δ13C and δ15N), and for Hg concentrations. Isotopic ratios were used to calculate trophic level, dietary reliance on the benthic food chain, and the proportion of zebra mussels in the diet. Reliance on the benthic food chain was a good predictor of Hg concentration in fish muscle, but not in turtle blood. The proportion of zebra mussels in the diet was not a good predictor of Hg in turtles or in fish. My results indicate that dietary reliance on the benthos should be considered in future tissue Hg modelling studies for fish, and that this predictor variable could be used to identify other fish species likely to be burdened by high concentrations of Hg.
Poesia e soddisfazione orale (1931)
Poetry as an oral outlet
Creators: name: Brill, Abraham Arden; -
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Poesia; Psicoanalisi; Fase orale; Motto di spirito; Freud.
Poetry; Psychoanalysis, Oral stage; Joke; Freud.

description: Il testo prende spunto da alcune osservazioni freudiane, relative fra l’altro al piacere che il bambino trae dal giocare con le parole come grado preliminare del motto di spirito. Come si conviene a un seguace zelante, Brill estende e radicalizza la portata del rilievo freudiano tentando di stabilire un legame, o almeno un punto di contatto, fra la poesia in senso generico e le varie forme di soddisfazione orale. Ne risultano accostamenti inediti e per il lettore contemporaneo lievemente comici: se l’arte poetica può essere vista come espressione dei misteri di una Erotica orale, il rapporto poeta-buongustaio non può che essere dei più stretti. Per definire e circoscrivere l’ambito dell’appagamento orale che si realizza nella poesia, Brill passa in rapida rassegna le varie forme che tale appagamento assume nei nevrotici, negli psicotici, nel bambino, nel primitivo. Le conclusioni, purtroppo, sono assai generiche: molti poeti non vanno oltre la fase orale e danno chiari segni di una fissazione dello sviluppo libidico a tale stadio
description: The text is inspired by some of Freud’s observations, regarding, among other things, the pleasure the child takes from playing with words as preliminary degree of wit. As zealous follower, Brill extends and intensifies the importance of Freud’s thought trying to establish a link, or at least a point of contact between the poetry in a generic sense and the various forms of oral gratification. This gives rise to unusual associations that are for the contemporary reader slightly comical: if poetry can be seen as an expression of the mysteries of oral Erotica, the relationship between poet and gourmet can only be the closest. To define and limit the scopes of fulfillment that is realized in oral poetry, Brill passes rapidly through the various forms this satisfaction takes in neurotics, in psychotics, in the child, in the primitive. The conclusions, unfortunately, are very general: many poets do not go beyond the oral stage and give clear signs of a fixation of libidinal development at this level.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
title: Alte Texte - neu gelesen: »Team« – Erfahrungen mit einer problematischen therapeutischen Interaktionsfigur in der Psychiatrie
Creators: name: Kisker, Karl
name: Elgeti, Hermann
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: Sozialpsychiatrische Informationen, vol. 53, no. 3, p. 47
Exploring the Experiences of Therapists After Participating in an Intensive Mindfulness Program
Creators: name: Lee, Tracie S.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Mindfulness
Hermeneutic Phenomenology
Therapeutic Practice
Therapist Self-Care
Therapist Training
Mindfulness-Oriented Interventions
Mindfulness-Informed Therapy

description: The purpose of this study was to explore whether and in what ways an intensive eight-week Mindfulness-Based Symptom Management (MBSM) program might shape the therapeutic experiences of therapists. I used a hermeneutic phenomenological approach to interview and develop in-depth descriptions of four therapists’ experiences in relation to mindfulness and their therapeutic practices. The data collection consisted of: (1) a telephone screening interview; (2) pre-mindfulness training interview; (3) post-mindfulness training interview; (4) field notes based on my observations, subjective experiences, and beginning analyses; (5) and member-checks to verify the accuracy of my interpretations of participants’ interview responses. The results pointed to several common themes indicating the changes therapists described after participating in the mindfulness program. Themes denoting the reported changes were organized into three categories: (1) personal relationship with mindfulness; (2) relationship between mindfulness and therapeutic experiences; and (3) mindfulness-oriented interventions performed in therapy. The findings indicated that mindfulness training is associated with the enhancement of important relational attitudes and skills of therapists, including more acceptance of where clients are at, more presence in therapy, increased capacity to listen, openness and curiosity, and more compassion and empathy. In addition, mindfulness training may be linked to improved reflexive abilities, which has implications for more intentional and ethical decision-making in therapy. Further, the findings also indicated that mindfulness training may be linked to improvements in emotion regulation by decreasing stress, increasing feelings of relaxation and calmness, improving awareness of negative emotional and cognitive states as well as the ability to interrupt these negative cycles. As such, this study pointed to several potential benefits for the inclusion of mindfulness training in therapists’ self-care practices as well as in therapist education.
James Elkins, "La pittura cos’è? Un linguaggio alchemico", Mimesis, Milano 2012
Creators: name: Gabriele, Marta; Università Di Bologna
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013

description: James Elkins, "La pittura cos’è? Un linguaggio alchemico", Mimesis, Milano 2012 – recensione a cura di Marta Gabriele
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
The oceanic feeling and the Cosmic Self in contemporary artistic creation
Il sentimento oceanico e il Sé Cosmico nella creazione artistica contemporanea
Creators: name: Sapienza, Claudio; Università Di Bologna
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Contemporary art, Ocean feeling; Cosmic Self; Land Art;
Arte contemporanea; Sentimento oceanico;Sé cosmico; Land Art.

description: This inquire develops into the sphere of the contemporary art, through the example of ‘isolated’ artists – like Metson, Penone, Mendieta – and that of land artists.  They make go deep into the matter of archetypical relation man-nature, throwing light upon the ‘Ocean Feeling’ which give voice to ‘Self-Cosmic’, innate in everyone. This is a very complex and wide subject, reason why it must to imply historical references – like Platone, Dufrenne, Freud and Rolland – and valuable carefully studies by contemporary intellectuals – as Fachinelli and Mercurio. It make psychological, cultural and anthropological presupposed in evidence, which induce the man-artist to a not individualistic art, but extend and universal. This proves how contemporary art and psychology have common intuitions and objects, at all times.
description: L’ambito in cui si sviluppa questa indagine è quello delle arti visive contemporanee, attraverso l’esempio di esperienze condotte da artisti “isolati” – quali Metson, Mendieta e Penone – e dalla folta e prolifica schiera dei land artists, che hanno approfondito una ricerca fondata sulla relazione uomo-natura in senso archetipico, per l’affermazione di un autentico sentimento oceanico, che da voce al cosiddetto Sé Cosmico insito in ciascun individuo. La tematica è così ampia e complessa da includere sia riferimenti teorici ormai storicizzati – da Platone a Freud, da Rolland a Dufrenne – sia preziosi ed illuminanti contributi offerti da intellettuali contemporanei – da Fachinelli a Mercurio. Si pongono in evidenza, pertanto, i presupposti psicologici, culturali ed antropologici che spingono l’uomo-artista verso un tipo di creazione artistica che ha i tratti di un’espressione non esclusivamente personale ed individualistica, bensì allargata ed universale, dimostrando quanto l’arte e la psicologia contemporanee, come da sempre, abbiano intuizioni ed obiettivi comuni.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
Claude Cahun and Suzanne Malherbe: an "amour fou"
Claude Cahun e Suzanne Malherbe: un "amour fou"
Creators: name: Mazzucchelli, Silvia
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Claude Cahun; Susanne Malherbe; Photography; Homosexuality
Claude Cahun; Suzanne Malherbe; Fotografia; Omosessualità

description: Claude Cahun is a writer and photographer born in Nantes in 1894. The purpose of this work is to explore her polymorphic and fluctuating identity through the artistic and affective link with her partner Suzanne Malherbe. Starting from the analysis of the iconic themes composing the visual symbol used by the two artists to sanction the exclusivity of their affair, we can conclude that Claude Cahun, by the means of her partner, becomes the absolute protagonist of her work, demolishing the wall between reality and art.
description: Questo lavoro si propone di esplorare l’identità polimorfa e fluttuante della scrittrice e fotografa Claude Cahun nata a Nantes nel 1894, attraverso il connubio artistico e affettivo che la lega alla compagna Suzanne Malherbe. A partire dall’analisi dei motivi iconici che compongono il simbolo visivo con cui le artiste sanciscono l’esclusività della loro unione, si approda alla conclusione che tramite la compagna, Claude Cahun riesca a divenire l’assoluta protagonista della propria opera, sino ad abbattere ogni barriera tra realtà ed arte.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
Translation and Psychoanalysis
Traduzione e psicoanalisi
Creators: name: Bocci, Laura
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: Psychoanalysis; Translation; Freud; Slips.
Traduzione; Psicoanalisi; Freud; Lapsus.

description: This contribution takes as a starting point the freudian idea of the constitution of the Self as progressive “Niederschrift”, a sort of accumulation of layers “overwriting” themselves one upon the  other. The Concept of “Uebertragung” covers thus two different areas: the one is Psychoanalysis, the other is Translation. The two concepts are not only metaphorically connected. In this contribution Laura Bocci explores the subjectivity of the translators both in her/his cultural and linguistic choices, misreadings, even slips and mistakes. Bocci explores the realm of the desire and motivations leading the translator to her/his activity, her/his idiosyncrasies - between physis and mimesis - towards the translated authors, and the role of “empathy” in the process of translation. The central idea points out the pattern of a mixed subjectivity (the translator’s and the author’s), i.e. intersubjectivity arising from the translated text.
description: Questo contributo prende le mosse dall’idea freudiana della costruzione del Sé come progressiva “Niederschrift”, una sorta di accumulazione di livelli che si “sovrascrivono” l’uno sull’altro. Il concetto di “Uebertragung” ricopre dunque due aree differenti: la prima è la Psicoanalisi, l’altra è la Traduzione. I due concetti sono connessi tra loro, e non solo da un punto di vista metaforico. Laura Bocci esplora la soggettività dei traduttori nelle loro scelte culturali e linguistiche, nei loro fraintendimenti e persino nei lapsus e negli errori. L’autrice esplora il campo del desiderio e delle motivazioni che portano il traduttore alla sua attività, alle sue idiosincrasie – tra physis e mimesis – nei confronti degli autori tradotti, e il ruolo dell’empatia nel processo di traduzione. L’idea centrale evidenzia il pattern di una “soggettività mescolata”(quella del traduttore e quella dell’autore), cioè di una intersoggettività che nasce dal testo tradotto.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
A Generalised and Adaptable Reinforcement Learning Stopping Method
Creators: name: Bin-Hezam, Reem
name: Stevenson, Mark
Publisher: name: arXiv
Year: 2025
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: This paper presents a Technology Assisted Review (TAR) stopping approach based on Reinforcement Learning (RL). Previous such approaches offered limited control over stopping behaviour, such as fixing the target recall and tradeoff between preferring to maximise recall or cost. These limitations are overcome by introducing a novel RL environment, GRLStop, that allows a single model to be applied to multiple target recalls, balances the recall/cost tradeoff and integrates a classifier. Experiments were carried out on six benchmark datasets (CLEF e-Health datasets 2017-9, TREC Total Recall, TREC Legal and Reuters RCV1) at multiple target recall levels. Results showed that the proposed approach to be effective compared to multiple baselines in addition to offering greater flexibility.
description: Accepted by SIGIR2025
Potential Role of αKAP, a CaMKII Kinase Anchoring Protein in Myocardium
Creators: name: Hawari, Omar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: CaMKII
cardiomyocytes
SERCA2a
αKAP
Anchoring protein
cardiac contraction

description: The Sarco-endoplasmic Ca2+ ATPase (SERCA2a) plays a crucial role in sequestering cytosolic calcium into the sarco-endoplasmic reticulum (SR/ER) and is an important regulator of muscle contraction and relaxation. Recent findings suggest that a novel CAMKIIα splice variant, αKAP, that plays the role of a CAMKII anchoring protein in the myocardium, also directly interacts with SERCA2a. We examined the effects of αKAP on SERCA2a activity using transfection of HEK-293T cells as well as lentiviral infection of primary neonatal mouse cardiomyocytes (NMCM). Our data showed that αKAP reduced Ca2+ ATPase activity, and downregulated SERCA2a expression in both HEK-293T cells coexpressing αKAP and SERCA2a, as well as NMCM overexpressing αKAP. Interestingly in a rat model of myocardial infarction, αKAP expression was found to be elevated, alongside elevated CaMKIIδ, and depressed SERCA2a expression. These data suggest that αKAP may be a unique regulator of SERCA2a activity and cardiac function.
Macroscale Analysis of Strain Path Change Effects in AA3104 by Digital Image Correlation
Creators: name: Lan, Yusha
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Strain path change effects
AA3104
Digital image correlation

description: Cold rolled aluminum is a widely used metal in industry. The forming limit diagram (FLD) which is commonly used to predict safe deformation parameters currently fails to predict the uniform elongation after non-proportional strain path often found in industrial operations. In this work, a non-proportional strain path change in aluminum alloy 3104 going from plane strain tension to uniaxial tension was investigated. Plane strain tensile tests have been carried out to various pre-strains (3%, 6% and 9%), followed by uniaxial tensile tests at various orientation with respect to the tensile direction (0°, 45° and 90°). Digital image correlation (DIC) was employed to analyze the strain distribution in the sample during deformation. The mechanical response was studied as a function of pre-strain and reloading angle to quantify the effect of strain path change on AA3104.
Human Head Stiffness Rendering
Creators: name: Minggao, Wei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Multimedia haptics
stiffness property rendering
models semantic registration
adaptive shape modification
nonlinear finite element modeling

description: The technology of haptics rendering has greatly enriched development in Multimedia applications, such as teleoperation, gaming, medical and etc., because it makes the virtual object touchable by the human operator(s) in real world. Human head stiffness rendering is significant in haptic interactive applications as it defines the degree of reality in physical interaction of a human avatar created in virtual environment. In a similar research, the haptic rendering approach has two main types: 1) Haptic Information Integration and 2) Deformation Simulation. However, the complexity in anatomic and geometric structure of a human head makes the rendering procedure challenging because of the issues of accuracy and efficiency. In this work, we propose a hybrid method to render the appropriate stiffness property onto a 3D head polygon mesh of an individual user by firstly studying human head's sophisticated deformation behaviour and then rendering such behaviour as the resultant stiffness property on the polygon mesh. The stiffness property is estimated from a semantically registered and shape-adapted skull template mesh as a reference and modeled from soft tissue's deformation behaviour in a nonlinear Finite Element Method (FEM) framework. To render the stiffness property, our method consists of different procedures, including 3D facial landmark detection, models semantic registration using Iterative Closest Point (ICP) technique, adaptive shape modification processed with a modified Weighted Free-Form Deformation (FFD) and FEM Simulation. After the stiffness property is rendered on a head polygon mesh, we perform a user study by inviting participants to experience the haptic feedback rendered from our results. According to the participants' feedback, the head polygon mesh's stiffness property is properly rendered as it satisfies their expectation.
Choice, diversity and coordination: improving access to social housing
Creators: name: Hulse, Kathleen
Publisher: name: Swinburne
Year: 2024

description: Allocations systems lie at the core of social housing. They determine who is eligible for housing (and who is not), the order of providing assistance, and matching of households with specific properties, as well as affecting all aspects of housing providers’ operations including tenancy management, asset planning and management, rent revenue, and ultimately financial viability. This article raises some issues about allocations, which are central to discussions about the future of public housing in Australia. It reports, and reflects, on some of the findings of recent research (Hulse and Burke 2004) for the Australian Housing and Urban Research Institute (AHURI), although it should be emphasised that the views expressed are those of the author not AHURI Ltd.
Lärmauswirkungen des Einsatzes von Drohnen auf die Umwelt
Creators: name: Becker, Stefan
name: Gutsche, Dominic
name: Schäffer, Beat
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: subject: Lärmwirkung
subject: Lärm
subject: Geräuschpegel
subject: Schallmessung
subject: Drohne
subject: UAV
subject: Überfluggeräuschmessung
subject: Lärm

description: Drohnen (unbemannte Luftfahrzeuge) haben sich in den vergangenen Jahren zu Geräten entwickelt, die größere Strecken zurücklegen und dabei für eine Vielzahl von Aufgaben eingesetzt werden können. Die zudem stetig zunehmende Zahl dieser Fluggeräte wirft die Frage nach den Geräuschauswirkungen des Betriebs dieser Geräte auf. Hierüber liegen derzeit weder national noch international fundierte Erkenntnisse vor. Durch eine Literaturstudie wurde der aktuelle Wissensstand zu den folgenden Themenbereichen zusammenzutragen und Vorschläge für die Weiterentwicklung erarbeitet: - In welchen Bereichen ist der Einsatz von Drohnen in der nächsten Zeit zu erwarten? - Welche Geräuschemissionen verursachen Drohnen? - Welche psychoakustischen Erkenntnisse gibt es zum Einsatz von Drohnen? - Welche rechtlichen Rahmenbedingungen gelten für den Betrieb von Drohnen? Quelle: www.umweltbundesamt.de
description: Drohnen (unbemannte Luftfahrzeuge) haben sich in den vergangenen Jahren zu Geräten entwickelt, die größere Strecken zurücklegen und dabei für eine Vielzahl von Aufgaben eingesetzt werden können. Die zudem stetig zunehmende Zahl dieser Fluggeräte wirft die Frage nach den Geräuschauswirkungen des Betriebs dieser Geräte auf. Hierüber liegen derzeit weder national noch international fundierte Erkenntnisse vor. Durch eine Literaturstudie wurde der aktuelle Wissensstand zu den folgenden Themenbereichen zusammenzutragen und Vorschläge für die Weiterentwicklungerarbeitet:    In welchen Bereichen ist der Einsatz von Drohnen in der nächsten Zeit zu erwarten?    Welche Geräuschemissionen verursachen Drohnen?    Welche psychoakustischen Erkenntnisse gibt es zum Einsatz von Drohnen?    Welche rechtlichen Rahmenbedingungen gelten für den Betrieb von Drohnen?
Immunomodulation of Embryonic Stem Cell-produced MFG-E8 on T Cells
Creators: name: Tan, Yuan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Embryonic stem cell
T cell
PKCθ
MFG-E8
Immune

description: Embryonic stem cells (ESCs) possess certain immunomodulatory properties; the defined components in ESCs, however, are largely unknown. Based on proteomic database, I report here that milk fat globule epidermal growth factor 8 (MFG-E8) is a key component in ESCs to suppress T cell activation and regulate T cell polarization. MFG-E8 is enriched in undifferentiated ESCs while diminishing in differentiated ESCs. Neutralizing ESC-derived MFG-E8 substantially ameliorates the suppressive effects of ESCs on T cell activation and proliferation. Additionally, MFG-E8 in ESCs is capable of up-regulating T regulatory cells. I further prove that MFG-E8 suppresses T cell activation and regulates T cell polarization through inhibiting PKCθ phosphorylation. In vivo teratoma formation assay reveals an increase in ESC engraftments across allogeneic barriers with less immunologic rejection by up-regulation of MFG-E8 expression in ESCs, further validating the immunosuppressive properties of MFG-E8. Identifying an important immunoregulatory component in ESCs will greatly facilitate stem cell-based therapies.
ImageR: Enhancing Bug Report Clarity by Screenshots
Creators: name: Tan, Xuchen
name: Yadav, Deenu
name: Ahmed, Faiz
name: Nayebi, Maleknaz
Publisher: name: arXiv
Year: 2025
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: In issue-tracking systems, incorporating screenshots significantly enhances the clarity of bug reports, facilitating more efficient communication and expediting issue resolution. However, determining when and what type of visual content to include remains challenging, as not all attachments effectively contribute to problem-solving; studies indicate that 22.5% of images in issue reports fail to aid in resolving the reported issues. To address this, we introduce ImageR, an AI model and tool that analyzes issue reports to assess the potential benefits of including screenshots and recommends the most pertinent types when appropriate. By proactively suggesting relevant visuals, ImageR aims to make issue reports clearer, more informative, and time-efficient. We have curated and publicly shared a dataset comprising 6,235 Bugzilla issues, each meticulously labeled with the type of image attachment, providing a valuable resource for benchmarking and advancing research in image processing within developer communication contexts. To evaluate ImageR, we conducted empirical experiments on a subset of these reports from various Mozilla projects. The tool achieved an F1-score of 0.76 in determining when images are needed, with 75% of users finding its recommendations highly valuable. By minimizing the back-and-forth communication often needed to obtain suitable screenshots, ImageR streamlines the bug reporting process. Furthermore, it guides users in selecting the most effective visual documentation from ten established categories, potentially reducing resolution times and improving the quality of bug documentation. ImageR is open-source, inviting further use and improvement by the community. The labeled dataset offers a rare resource for benchmarking and exploring image processing in the context of developer communication.
description: Paper accepted to EASE 2025
Recent Advances in Single-Particle Electron Microscopic Analysis of Autophagy Degradation Machinery
Creators: name: Cheung, Yiu Wing Sunny
name: Nam, Sung-Eun
name: Yip, Calvin K.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Macroautophagy (also known as autophagy) is a major pathway for selective degradation of misfolded/aggregated proteins and damaged organelles and non-selective degradation of cytoplasmic constituents for the generation of power during nutrient deprivation. The multi-step degradation process, from sequestering cytoplasmic cargo into the double-membrane vesicle termed autophagosome to the delivery of the autophagosome to the lysosome or lytic vacuole for breakdown, is mediated by the core autophagy machinery composed of multiple Atg proteins, as well as the divergent sequence family of selective autophagy receptors. Single-particle electron microscopy (EM) is a molecular imaging approach that has become an increasingly important tool in the structural characterization of proteins and macromolecular complexes. This article summarizes the contributions single-particle EM have made in advancing our understanding of the core autophagy machinery and selective autophagy receptors. We also discuss current technical challenges and roadblocks, as well as look into the future of single-particle EM in autophagy research.
Experimental Investigation of Effect of Windshield Barriers on the Aerodynamic Properties of the Multi-box Bridge Decks
Creators: name: Chen, Xi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: With the development of aerodynamic investigation methods, long-span bridge projects gradually became more open to adopt challenging geometric optimizations and countermeasure implementations. Thus the bridge girder decks improved as well, changing from the compact box-deck girders shapes, to twin-box and multi-box deck sections. The objectives of the current research are first to experimentally investigate the aerodynamic properties of a new type of bridge deck with multiple-decks consisting of two side decks for traffic lanes and two middle decks for railway traffic. Secondly, the aerodynamic effect of the windshield barriers with two different heights (30 mm and 50 mm) was experimentally analyzed for the multiple-deck bridge deck model. Finally, the Iterative Least Squares (ILS) method was used for extracting the eight flutter derivatives of this new type of deck section model. Furthermore, a detailed comparison of the aerodynamic characteristics between the current research model and other types of box girder bridges was carried out for identifying the similarities and discrepancies in the overall aerodynamic performance of the bridge deck. A wind tunnel facility was used for testing the force coefficients and the flutter derivatives for the multi-box deck model for wind speeds in the range of 0.8 m/s to 11.0 m/s. In total, 301 test cases for 7 different attack angles (±6°, ±4°, ±2°, 0°) and two different windshield heights (30 mm and 50 mm) were carried out, as part of this research.
Récupérer les valeurs du passé pour orienter le futur : Sankɔfa comme principe politique des communautés akans du Ghana contemporain
Creators: name: Isabelle, Bernard
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Akan
Ghana
politique
tradition
temporalité
morale
normes
autorité
chefs
festivals
religion
sankofa
christianisme

description: Comment récupérer les legs du passé pour construire le présent sur un héritage traditionnel, en s’adaptant aux nouvelles réalités du présent et orientant le futur? Ce travail se penche sur une réponse propre à ce problème, celle des communautés akans du Ghana. Nous tenterons de montrer que c’est par une évaluation normative : « quels sont les bons et les mauvais éléments du passé? » que ces communautés ont entrepris de juger quels étaient les éléments méritant d’être récupérés. Les communautés akans ont conservé cette idée (de juger les évènements du passé selon une évaluation normative) dans la tradition notamment par le biais d’un idéogramme nommé sankↄfa dans la langue locale. Elle se retrouve au cœur de la culture et notamment par le biais des pratiques et rituels. Le politique est définit comme l’ensemble des actions humaines participant à la construction du système normatif, fondé sur une hiérarchisation collective dynamique des valeurs et canalisant les désirs et passions des êtres humains vers des possibilités d’action spécifiques. Les performances politiques (rituels et transmission de la tradition) contribuent à édifier, solidifier ou transvaluer l’autorité du système moral. Dans ce travail, nous soutenons que les communautés akans renforcent l’autorité politique de leur tradition par le biais de performances politiques. En déterminant ce qu’est le « Bien » et le « Mal », les Akans canalisent les possibilités d’action et orientent les comportements collectifs de leur communauté. Ce travail étudie un aspect de la relation entre culture et temps dans les communautés akans du Ghana. En analysant leur processus d’interprétation du passé, par lequel un héritage moral est récupéré pour être adapté au présent et orienter les actions futures des membres de leurs communautés, nous constatons qu’une tradition peut s’adapter à l’avenir tout en préservant les « bons » éléments du passé, et ce, comme suite d’un jugement moral continu, consistant en la discrimination morale des antécédents. Ce jugement continuel peut alors être considéré comme une pratique politique, et non seulement comme une pratique culturelle.
Emergency Preparedness and Response Planning: A Value-Based Approach to Preparing Coastal Communities for Sea Level Rise
Creators: name: Chung, Alexander Quoc Huy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Climate Change Adaptation
Emergency Management
Disaster Risk Reduction
Decision Analysis
Community Adaptation
Adaptive Strategies
Simulation
Table-Top Exercises

description: Extreme weather events have become a common occurrence and coastal communities are adversely affected by it. Studies have shown that the changing climate has increased the frequency and severity of storms, surging sea levels, and floods, as was seen with Hurricane Sandy (2012) and Typhoon Haiyan (2013). The need to be proactive in preparing for these events, as a means of climate change adaptation and disaster risk reduction, is evident. This study focuses on the formal definition, measurement and simulation of coastal community preparedness and response to severe storm events. Preparedness and response requires resources, emergency plans, informed decision making and the ability to cope with unexpected events. A suite of preparedness indicators is developed using a three level hierarchical framework in the construction of a coastal community preparedness index to evaluate resources and plans. Informed decision making for emergency management personnel in the Emergency Operations Centre (EOC) is evaluated through a table-top exercise using a five-phase approach. Lastly, decision making with risk is introduced with a storm decision making simulation model. This study is applied to the case of the breakwater failure in the coastal community of Little Anse, Cape Breton, Nova Scotia.
Motivating Francophone ESL Learners in Quebec: A Pilot Study on the Potential Role of eTandem with Anglophone Peers in Ontario
Creators: name: Flick, Laura G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Second language motivation
English as a second language
eTandem
Quebec

description: With globalization and the growth of the World Wide Web, it is increasingly important for non-Anglophone students to acquire a functional level of English before graduating from secondary school. However, Francophone students in the province of Quebec who are learning English as a second language (ESL) face particular challenges that hinder their development of English proficiency, not the least of which is motivation. This quasi-experimental case study explores the effects of an eTandem project with Anglophone peers on the motivation of Francophone ESL learners in secondary school. The results indicate that Francophone students who completed the eTandem project showed greater motivational intensity, greater desire to learn the target language, and less anxiety. It also appears that technical problems, scheduling issues and anxiety contributed to the majority of Francophone students discontinuing the project. Recommendations are made to integrate eTandem projects into Quebec’s ESL curriculum and to address the anxiety issues of students in class.
Older Workers’ Perspectives on Age and Aging: Exploring the Predictors of Communication Patterns and Knowledge Transfer
Creators: name: De Blois, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: communication accommodation theory
social identity theory
knowledge transfer
intergenerational
intergenerational communication
workplace communication
workplace stereotypes
ageism
ageist stereotypes
workplace collaboration
stereotypes
communication patterns
perception

description: The Canadian population is aging, as is the Canadian workforce. Today, four generations find themselves cohabiting in the workforce together. This may have an impact on workplace collaboration and communication, as both of these processes are influenced by group perceptions. Academic research has focused upon workplace interactions mainly from a younger worker’s perspective; hence, the older worker’s voice has been overlooked. The objective of this study is thereby from an older worker’s perspective, to understand how generations perceive each other in the workplace, and further, understand how these perceptions influence intergenerational communication and collaboration. To do so, we have relied upon Communication Accommodation Theory and Social Identity Theory, and have conducted a survey to measure the influence of ageist stereotypes on communication and its accommodation, in addition to such influences on knowledge transfer. Theoretical and practical implications are discussed.
Snowmen. David Lynch as photograph and "The Uncanny"
Pupazzi di neve. David Lynch fotografo e l’"Unheimliche"
Creators: name: Lanzi, Paolo Sebastiano
Publisher: name: Dipartimento delle Arti - Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: David Lynch; Photography; Cinema; Uncanny.
David Lynch; Fotografia; Cinema; Perturbante

description: David Lynch’s work is not limited to the cinema, as the 2007 exhibition The Air is on Fire, held at the Cartier Fondation in Paris, showed. However, theoretical studies have neglected what galleries and museums have highlighted for some time: Lynch the painter, photographer, musician and polyhedral artist. The article focuses on a photographic series, Snowmen and is taken from a piece of research by Paolo Sebastiano Lanzi on David Lynch the photographer. In the light of Freud’s essay on The Uncanny (Das Unheimliche, 1919), the Snowmen are interpreted as images of death. Aspects of the artist-director’s poetics come to the fore, such as the unease of the Inland Empire or certain ideas integral to Surrealism. The study of Lynch’s photographic production fills a void in the critical analysis of his work, which should be reappraised in a much wider perspective.
description: L’opera di David Lynch non si limita al cinema, come ha dimostrato l’esposizione del 2007 alla Fondation Cartier di Parigi, The Air is on Fire. Tuttavia gli studi teorici hanno trascurato ciò che gallerie e musei hanno evidenziato da tempo: il Lynch pittore, fotografo, musicista, artista poliedrico. L’articolo si focalizza su una serie fotografica, Snowmen, ed è tratto da una ricerca di Paolo Sebastiano Lanzi sulla figura di David Lynch fotografo. Alla luce del saggio di Freud sul Perturbante (Das Unheimliche, 1919) si interpretano gli Snowmen come immagini di morte. Si chiariscono alcuni aspetti della poetica dell’artista-regista, come l’inquietudine dell’Inland Empire o di certe idee care al Surrealismo. Lo studio della produzione fotografica di Lynch riempie un vuoto nell’analisi critica sul suo lavoro, che va necessariamente riconsiderato in una prospettiva più ampia.
description: PsicoArt – Rivista on line di arte e psicologia; Vol 3, N° 3 (2013)
Ideal Performance Practice for Silent Film: An Overview of How-to Manuals and Cue Sheet Music Accompaniment from the 1910s – 1920s
Creators: name: Anderson, Shana C.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Silent film music
cue sheets
improvisation
Bradford
Luz
The Cat and the Canary
The Gaucho

description: This thesis argues that how-to manuals and cue sheets are indicative of ideal performance practice amongst musicians from the silent film era. Pre-scored music was widely practiced amongst musicians. How-to manuals and cue sheets helped the musician accurately and consistently accompany a film. Authors of period manuals include W. Tyacke George, Edith Lang and George West, Ernst Luz and George Tootell. Compilers of cue sheet include James C. Bradford, Ernst Luz, Edward Kilenyi and Michael P. Krueger. Cue by cue analyses of The Cat and the Canary and The Gaucho show a high repetition of music, establishing continuity between the music played and the image on the screen. This shows how compilers associated music and film. These manuals and cue sheets prove that the musician community strove for a close connection between the image on screen and accompaniment. By 1920, arbitrary improvisation was unacceptable.
One Documentation Does Not Fit All: Case Study of TensorFlow Documentation
Creators: name: Thirimanne, Sharuka Promodya
name: Lemango, Elim Yoseph
name: Antoniol, Giulio
name: Nayebi, Maleknaz
Publisher: name: arXiv
Year: 2025
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Software documentation guides the proper use of tools or services. With the rapid growth of machine learning libraries, individuals from various fields are incorporating machine learning into their workflows through programming. However, many of these users lack software engineering experience, affecting the usability of the documentation. Traditionally, software developers have created documentation primarily for their peers, making it challenging for others to interpret and effectively use these resources. Moreover, no study has specifically focused on machine learning software documentation or analyzing the backgrounds of developers who rely on such documentation, highlighting a critical gap in understanding how to make these resources more accessible. This study examined customization trends in TensorFlow tutorials and compared these artifacts to analyze content and design differences. We also analyzed Stack Overflow questions related to TensorFlow documentation to understand the types of questions and the backgrounds of the developers asking them. Further, we developed two taxonomies based on the nature and triggers of the questions for machine learning software. Our findings showed no significant differences in the content or the nature of the questions across different tutorials. Our results show that 24.9% of the questions concern errors and exceptions, while 64.3% relate to inadequate and non-generalizable examples in the documentation. Despite efforts to create customized documentation, our analysis indicates that current TensorFlow documentation does not effectively support its target users.
description: COMPSAC 2025 paper
The Effects of Sexual Selection and Ecology on Adaptation and Diversification in Drosophila Melanogaster
Creators: name: Arbuthnott, Devin W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: sexual selection
sexual conflict
adaptation
experimental evolution
Drosophila melanogaster

description: Sexual selection is pervasive in nature and plays an important role in the evolution of biological diversity both within and among sexual species. However, while we have a good understanding of how competition for reproductive opportunities and mate choice can drive the evolution of exaggerated secondary sexual traits, much less is known about how sexual selection interacts with other forms of natural selection and the consequences such interactions may have for adaptation to novel environments, the purging of deleterious mutations, and population divergence/speciation. In my thesis, I carried out a series of experiments with the fruit fly Drosophila melanogaster to test hypotheses regarding the operation of sexual selection and to broaden our understanding of how sexual selection may influence adaptation and diversification. Theory suggests that natural and sexual selection may align to promote adaptation and the purging of deleterious mutations, although the harm imposed by sexual conflict may counter this. In two separate experiments, I find no evidence that sexual selection promotes adaptation to a novel environment and, rather than aligning with natural selection, I find that the effects of sexual conflict may cause sexual selection to hamper the purging of deleterious mutations. With respect to diversification, sexual conflict has been suggested to be an important, non-ecological driver of population divergence. However, the traits involved in sexual conflict may also affect nonsexual fitness and natural selection may therefore act to constrain diversification. Using an evolution experiment, I demonstrate ecologically-dependent parallel evolution of traits involved in sexual conflict, providing evidence for ecology’s importance in divergence via sexual conflict. Overall, my work has shed light on the interaction of natural and sexual selection and the consequences this may have beyond the evolution of exaggerated sexual displays and armaments.
"Deadly Women": Examining (Audio)Visual (Re)Presentations of Violent Women and Girls in Infotainment Media
Creators: name: Scheuneman Scott, Isabel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Women
girls
criminalized women
gender
violence
violent crime
infotainment
media
media analysis
qualitative content analysis
Deadly Women

description: Women have historically been the subject of stereotypes – especially criminalized women as they are constructed in the mass media. These stereotypes become particularly problematic when they are invoked in infotainment media – a genre that combines information and entertainment and presents itself as primarily factual. As such, ideological messages delivered through infotainment are also (re)presented as truthful and may be more likely to be taken up by an unquestioning audience. This research aimed to answer the following research question: How does infotainment portray women who commit serious violent crime? In order to answer this question, a qualitative content analysis was employed and “Deadly Women”, a televised infotainment series that narrates and re-enacts true crime stories of women who kill, was selected as a case study. The sample consisted of previously identified typologies: mothers who kill their children, women who kill their partners, adolescent girls who kill, and vigilantes who kill their abusers. Stemming from a critical feminist framework, the analysis revealed that Deadly Women relies on two primary trajectories to explain the violence committed by women and girls. While both trajectories emphasized gendered stereotypes that involved emotionality and mental health issues, they were nonetheless distinct. The first trajectory evoked narratives of the ‘emotionless’ and ‘psychopathic’ perpetrator; while the second trajectory characterized the offender as overly ‘emotional’ and ‘depressed’. These trajectories, along with their related variables, problematically (re)presented violent women and girls in simplistic and dualistic manners that served to obscure rather than to clarify the circumstances surrounding their crimes.