cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury
Creators: name: Urban, Thomas J
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Keratin 8 and 18 (K8/K18) cytoskeletal proteins protect hepatocytes from undergoing apoptosis and their mutations predispose to adverse outcomes in acute liver failure (ALF). All known K8/K18 variants occur at relatively non-conserved residues and do not cause keratin cytoskeleton reorganization, whereas epidermal keratin-conserved residue mutations disrupt the keratin cytoskeleton and cause severe skin disease. The aim of our study was to identify keratin variants in idiosyncratic drug-induced liver injury (DILI). Methods Genomic DNA was isolated from 800 patients enrolled in an ongoing US multicenter study, with DILI attributed to a wide range of drugs. Specific K8/K18 exonic regions were PCR-amplified and screened by denaturing HPLC followed by DNA sequencing. The functional impact of keratin variants was assessed using cell transfection and immune staining. Results Heterozygous and compound amino acid-altering K8/K18 variants were identified in 86 DILI patients and non-coding variants in 15 subjects. Five novel amino acid-altering (K8 Lys393Arg, K8 Ala351Val, K8 Ala358Val, K8 Ile346Val, K18 Asp89His) and two non-coding variants were observed. Several variants segregated with specific ethnic backgrounds but were found at similar frequencies in DILI subjects and ethnically matched population controls. Notably, variants in highly conserved residues of K8 Lys393Arg (ezetimibe/simvastatin-related) and K18 Asp89His (isoniazid-related) were found in patients with fatal DILI. These novel variants also led to keratin network disruption in transfected cells. Conclusions Novel K8/K18 cytoskeleton-disrupting variants were identified in two patients and segregated with fatal DILI. Other non-cytoskeleton-disrupting keratin variants did not preferentially associate with DILI.
title: Radiation dosimetry in selective internal radiation treatment in patients with portosystemic shunts to umbilical veins
Creators: name: Ma, Wai Han
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Image registration
subject: Radioembolisation
subject: Dosimetry
subject: SPECT-CT
subject: CT
subject: Nuclear medicine

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Pretherapy Tc-99m MAA scan before Yttrium-90 radioembolisation is mandatory to assess lung shunting and extrahepatic uptake. Visualization of the recanalized umbilican vein in this breakthrough scan is not uncommon. Most centres believed that it...
ECLS-K Replication Project
Creators: name: Morgan, Grant
name: Renbarger, Rachel
name: Sulak, Tracey
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Teacher Education and Professional Development
subject: Science and Mathematics Education
subject: Education
subject: Educational Assessment, Evaluation, and Research
subject: Early Childhood Education
subject: Elementary Education

description: For ReScience X article
DehazeNet: An End-to-End System for Single Image Haze Removal
Creators: name: Cai, Bolun
name: Xu, Xiangmin
name: Jia, Kui
name: Qing, Chunmei
name: Tao, Dacheng
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Single image haze removal is a challenging ill-posed problem. Existing methods use various constraints/priors to get plausible dehazing solutions. The key to achieve haze removal is to estimate a medium transmission map for an input hazy image. In this paper, we propose a trainable end-to-end system called DehazeNet, for medium transmission estimation. DehazeNet takes a hazy image as input, and outputs its medium transmission map that is subsequently used to recover a haze-free image via atmospheric scattering model. DehazeNet adopts Convolutional Neural Networks (CNN) based deep architecture, whose layers are specially designed to embody the established assumptions/priors in image dehazing. Specifically, layers of Maxout units are used for feature extraction, which can generate almost all haze-relevant features. We also propose a novel nonlinear activation function in DehazeNet, called Bilateral Rectified Linear Unit (BReLU), which is able to improve the quality of recovered haze-free image. We establish connections between components of the proposed DehazeNet and those used in existing methods. Experiments on benchmark images show that DehazeNet achieves superior performance over existing methods, yet keeps efficient and easy to use.
title: With a little help from my friend, the breast thomosyntesis
Creators: name: Tischendorf, Carmen
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Image verification
subject: Diagnostic procedure
subject: Mammography
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To show selected cases of breast tomosynthesis of our institution, which provides a 3D imaging capability that allows more accurate detection and evaluation of lesions than in 2D mammography, by reducing the confounding effects of superimposed...
title: Segmentation of Proximal Femur from Computed Tomography Images Using a Novel Graph-cut Based Method with Shape Prior
Creators: name: Wang, Defeng
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Bones
subject: CT
subject: Segmentation
subject: Image registration

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Femur segmentation from computed tomography (CT) images is a fundamental problem in femur-related computer-assisted diagnosis and surgical planning/navigation [1]. In this study, a new automatic approach for segmentation of proximal femur from CT...
Slurry, Solution and Speciation Analysis By Inductively Coupled Plasma Atomic Emission Spectrometry
Creators: name: O'HANLON, KAREN LORRAINE
Publisher: name: University of Plymouth
Year: 1996

description: Inductively coupled plasma atomic emission spectrometry has been investigated for solution, slurry and speciation analysis. It has been shown that it is possible to optimise a simultaneous multielement analysis for slurry and solution samples using solid state detection and optimisation algorithms. A range of certified reference materials have been analysed using optimum conditions and results were in good agreement with certified values. Slurry nebulisation has been used for the first time in the analysis of NIST SRM Total Diet' and carbon black samples. Both radially and axially viewed ICP spectrometers were used in these studies. Modifications of the mass transport efficiency of solutions and slurries through the sample introduction system was illustrated upon EIE addition. The transport phenomenon was found to be dependent on the matrix element and not on the analyte of interest. A decrease in transport efficiency was found to be related to the mass of the EIE added. Solution and slurry atom and ion line intensity ratios obtained from an axially viewed ICP were used to illustrate emission enhancement when Mg was used as the thermometric species of interest. Enhancement was found to be spatially dependent and the energy transfer processes governing excitation were modified upon EIE addition. The magnitude of the enhancement effects for solutions and slurries differed, once transport effects had been negated, and this was attributed to variations in atomisation efficiency. A radially viewed ICP spectrometer was also used to monitor the effect of ElEs on solutions and slurries. The Abel integral technique was used to transform lateral profiles and Fe atom line ratios were calculated. 'Real' enhancement effects were apparent upon EIE addition when transport effects had again been negated. The plasma excitation temperature was used as a physical marker to determine the effect of EIE addition on solutions and slurries of Fe. The variation in Texc upon EIE addition was small but showed an increasing trend from Li to Cs. Radially obtained values of Texc were lower than literature values whereas preliminary values obtained axially compared well. It has been demonstrated that transient signal data may be obtained from an array-based spectrometer for speciation studies. The feasibility of reverse phase and size exclusion HPLC-ICP-AES has been demonstrated for the separation of a selection of organosilicon species of various molecular weights. Detection limits were in the range 0.1 to 5 ug ml-1 for a radially viewed plasma. The use of axial viewing when aspirating organic solvents as part of the mobile phase yields higher limits of detection owing to the noise that is measured.
The molecular portraits of breast tumors are conserved across microarray platforms
Creators: name: Ewend, Matthew G.
name: Wu, Junyuan
name: Oh, Daniel S.
name: Fan, Cheng
name: Hu, Zhiyuan
name: Qaqish, Bahjat
name: Nobel, Andrew
name: He, Xiaping
name: Carey, Lisa
name: Perou, Charles
name: Reynolds, Evangeline
name: Livasy, Chad
name: Sawyer, Lynda R
name: Dressler, Lynn
name: Liu, Yudong
name: Marron, JS
Publisher: name: BioMed Central Ltd
Year: 2006

description: Abstract Background Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However, validation is often unconvincing because the size of the test set is typically small. To overcome this problem we used publicly available breast cancer gene expression data sets and a novel approach to data fusion, in order to validate a new breast tumor intrinsic list. Results A 105-tumor training set containing 26 sample pairs was used to derive a new breast tumor intrinsic gene list. This intrinsic list contained 1300 genes and a proliferation signature that was not present in previous breast intrinsic gene sets. We tested this list as a survival predictor on a data set of 311 tumors compiled from three independent microarray studies that were fused into a single data set using Distance Weighted Discrimination. When the new intrinsic gene set was used to hierarchically cluster this combined test set, tumors were grouped into LumA, LumB, Basal-like, HER2+/ER-, and Normal Breast-like tumor subtypes that we demonstrated in previous datasets. These subtypes were associated with significant differences in Relapse-Free and Overall Survival. Multivariate Cox analysis of the combined test set showed that the intrinsic subtype classifications added significant prognostic information that was independent of standard clinical predictors. From the combined test set, we developed an objective and unchanging classifier based upon five intrinsic subtype mean expression profiles (i.e. centroids), which is designed for single sample predictions (SSP). The SSP approach was applied to two additional independent data sets and consistently predicted survival in both systemically treated and untreated patient groups. Conclusion This study validates the "breast tumor intrinsic" subtype classification as an objective means of tumor classification that should be translated into a clinical assay for further retrospective and prospective validation. In addition, our method of combining existing data sets can be used to robustly validate the potential clinical value of any new gene expression profile.
The Method_GTC and WLA
Creators: name: Sterken, Peter
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Plant Sciences
subject: Biological and Chemical Physics
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Physical Sciences and Mathematics
subject: Agriculture
subject: Physiology
subject: FOS: Biological sciences
subject: Life Sciences
subject: Biomechanical Engineering
subject: Physics
subject: Biochemistry, Biophysics, and Structural Biology
subject: Forest Sciences
subject: Engineering

description: It will be shown that the published “Generalised Tipping Curve” (GTC), which purportedly predicts the uprooting of trees based on empirical data, is suggestive of misinformation. Entirely different SIM and other curves were found that had already been in use since at least 1983 by comparatively unknown authors and 2003 (SIM curve) until now. This paper also shows that the highly-cited and influential proclamations regarding “dynamic” versus “quasi-static” WLA, may be incorrect as their results could perfectly be simulated with a simle formula for stiff brick-made chimneys.
title: Diffusion tensor magnetic resonance imaging in assessment of prognostic outcome of stroke patients
Creators: name: Elkholy, Shaima
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: MR-Functional imaging
subject: Imaging sequences
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Stroke is one of the leading cause of death worldwide especially in elderly population. It includes patients with arterial ischemic infarcts, intracranial hemorrhage, subarachnoid hemorrhage, and venous infarction. Conventional MR imaging cannot...
Anger Expression as Moral Courage
Creators: name: Sasse, Julia
name: Baumert, Anna
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: In this project, we explore anger expression as a form of moral courage. Utilizing a three-person punishment game, we investigate dispositional and situational determinants as well as goals of different forms (i.e., behavioral and emotional) of intervention against others' norm transgressions.
IPBES Guide on the production of assessments
Creators: name: IPBES
Publisher: name: Zenodo
Year: 2018

description: IPBES has been mandated to develop a guide to help address conceptual, procedural and practical aspects of IPBES assessments at all scales, and to promote consistency across different scales. Accordingly, the Multidisciplinary Expert Panel, supported by time-bound expert group, has developed a guide that serves as a ‘Roadmap’ and to focus on key elements assessment practitioners may want to take into account when undertaking an assessment within the context of IPBES. The Guide has been developed for experts who are taking part in assessments approved under IPBES be they thematic, methodological or general assessments of biodiversity and ecosystems at global, regional and sub-regional level. The Guide is also meant to assist those who might want to undertake IPBES inspired assessment at sub-regional, national and local level and to help facilitate that such assessments are compatible with larger scale IPBES approved assessments. The Guide is a living document which will be updated and expanded overtime to reflect the work of the IPBES task forces, expert groups and experiences of experts involved in IPBES assessments.
Covariant Constraints on Hole-ography
Creators: name: Engelhardt, Netta
name: Fischetti, Sebastian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Hole-ography is a prescription relating the areas of surfaces in an AdS bulk to the differential entropy of a family of intervals in the dual CFT. In (2+1) bulk dimensions, or in higher dimensions when the bulk features a sufficient degree of symmetry, we prove that there are surfaces in the bulk that cannot be completely reconstructed using known hole-ographic approaches, even if extremal surfaces reach them. Such surfaces lie in easily identifiable regions: the interiors of holographic screens. These screens admit a holographic interpretation in terms of the Bousso bound. We speculate that this incompleteness of the reconstruction is a form of coarse-graining, with the missing information associated to the holographic screen. We comment on perturbative quantum extensions of our classical results.
description: 26+4 pages, 16 figures; v2: references added, typos fixed
Can Masculinity Threats promote sexism and increase Gender Inequality?
Creators: name: bonneh‬‏, ‪yuval
name: Boshi, Inbar
name: Eisenstadt, Dina
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This pre-registration is our first registration, and is done as a part of Experimental Psychology class in Tel Aviv University.
Limits on the ions temperature anisotropy in turbulent intracluster medium
Creators: name: Santos-Lima, R.
name: Yan, H.
name: Pino, E. M. de Gouveia Dal
name: Lazarian, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Turbulence in the weakly collisional intracluster medium of galaxies (ICM) is able to generate strong thermal velocity anisotropies in the ions (with respect to the local magnetic field direction), if the magnetic moment of the particles is conserved in the absence of Coulomb collisions. In this scenario, the anisotropic pressure magnetohydrodynamic (AMHD) turbulence shows a very different statistical behaviour from the standard MHD one and is unable to amplify seed magnetic fields, in disagreement with previous cosmological MHD simulations which are successful to explain the observed magnetic fields in the ICM. On the other hand, temperature anisotropies can also drive plasma instabilities which can relax the anisotropy. This work aims to compare the relaxation rate with the growth rate of the anisotropies driven by the turbulence. We employ quasilinear theory to estimate the ions scattering rate due to the parallel firehose, mirror, and ion-cyclotron instabilities, for a set of plasma parameters resulting from AMHD simulations of the turbulent ICM. We show that the ICM turbulence can sustain only anisotropy levels very close to the instabilities thresholds. We argue that the AMHD model which bounds the anisotropies at the marginal stability levels can describe the Alfvenic turbulence cascade in the ICM.
description: 14 pages, 8 figures, accepted for publication on MNRAS
On the escape of CH4 from Pluto's atmosphere
Creators: name: Koskinen, T. T.
name: Erwin, J. T.
name: Yelle, R. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We adapted a multi-species escape model, developed for close-in extrasolar planets, to calculate the escape rates of CH4 and N2 from Pluto. In the absence of escape, CH4 should overtake N2 as the dominant species below the exobase. The CH4 profile depends strongly on the escape rate, however, and the typical escape rates predicted for Pluto lead to a nearly constant mixing ratio of less than 1 % below the exobase. In this case the CH4 escape rate is only 5-10 % of the N2 escape rate. Observations of the CH4 profile by the New Horizons/ALICE spectrograph can constrain the CH4 escape rate and provide a unique test for escape models.
description: Accepted to Geophysical Research Letters
A natural philosophy in arboriculture and (urban) forestry
Creators: name: Sterken, Peter
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Physical Sciences and Mathematics
subject: Agriculture
subject: Life Sciences
subject: Biomechanical Engineering
subject: Biochemistry, Biophysics, and Structural Biology
subject: Forest Sciences
subject: Engineering

description: A new theoretical framework has been constructed for the structural stability assessment of trees and palms. Physical laws and Natural Philosophy principles, scientific criteria, observation and empirical results from academic literature will be its confirmatory foundations. Hence, this implies an entirely new natural philosophy in arboriculture and (urban) forestry. However, it will not entirely be compatible with current methods such as the Visual Tree Assessment (VTA) of Mattheck and the pulling tests of Wessolly (SIM) and others. It will also be shown that the published “Generalised Tipping Curve” (GTC), which purportedly predicts the uprooting of trees based on empirical data, is suggestive of misinformation, as entirely different SIM and other curves were found that had already been in use since at least 1983 by comparatively unknown authors. This paper also analyses highly-cited and influential proclamations regarding the GTC and the “dynamic” versus “quasi-static” WLA, that may have, quite simply, sprouted from unconscious research bias. Nature does not follow predictions and extrapolations based on static beam theory or t/R criteria. Biological structures are governed by a continuous storage and release of energies and their struggle to withstand them, in agreement with Newton's laws of physics and Darwin's theory of evolution.
Quantum Annealing Correction with Minor Embedding
Creators: name: Vinci, Walter
name: Albash, Tameem
name: Paz-Silva, Gerardo
name: Hen, Itay
name: Lidar, Daniel A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum annealing provides a promising route for the development of quantum optimization devices, but the usefulness of such devices will be limited in part by the range of implementable problems as dictated by hardware constraints. To overcome constraints imposed by restricted connectivity between qubits, a larger set of interactions can be approximated using minor embedding techniques whereby several physical qubits are used to represent a single logical qubit. However, minor embedding introduces new types of errors due to its approximate nature. We introduce and study quantum annealing correction schemes designed to improve the performance of quantum annealers in conjunction with minor embedding, thus leading to a hybrid scheme defined over an encoded graph. We argue that this scheme can be efficiently decoded using an energy minimization technique provided the density of errors does not exceed the per-site percolation threshold of the encoded graph. We test the hybrid scheme using a D-Wave Two processor on problems for which the encoded graph is a 2-level grid and the Ising model is known to be NP-hard. The problems we consider are frustrated Ising model problem instances with "planted" (a priori known) solutions. Applied in conjunction with optimized energy penalties and decoding techniques, we find that this approach enables the quantum annealer to solve minor embedded instances with significantly higher success probability than it would without error correction. Our work demonstrates that quantum annealing correction can and should be used to improve the robustness of quantum annealing not only for natively embeddable problems, but also when minor embedding is used to extend the connectivity of physical devices.
description: 34 pages, 28 figures
title: Role of Venous Doppler Evaluation of Intrauterine Growth Retardation
Creators: name: Haroon, Hytham
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Foetal imaging
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Power Doppler
subject: Diagnostic procedure
subject: Foetus

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Intrauterine growth retardation is a common condition affecting about 10 % to 15 % of the general maternity population (1). It is associated with increased risk of intrauterine fetal death, intracranial haemorrhage, respiratory distress...
Experimental realization of stimulated Raman shortcut-to-adiabatic passage with cold atoms
Creators: name: Du, Yan-Xiong
name: Liang, Zhen-Tao
name: Li, Yi-Chao
name: Yue, Xian-Xian
name: Lv, Qing-Xian
name: Huang, Wei
name: Chen, Xi
name: Yan, Hui
name: Zhu, Shi-Liang
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Accurate control of a quantum system is a fundamental requirement in many areas of modern science ranging from quantum information processing to high-precision measurements. A significantly important goal in quantum control is to prepare a desired state as fast as possible with sufficiently high fidelity allowed by available resources and experimental constraints. Stimulated Raman adiabatic passage (STIRAP) is a robust way to realize high-fidelity state transfer but it requires a sufficiently long operation time to satisfy the adiabatic criteria. We here theoretically propose and then experimentally demonstrate a shortcut-to-adiabatic protocol to speed up the STIRAP. By modifying the shapes of the Raman pulses, we experimentally realize a fast and high-fidelity stimulated Raman shortcut-to-adiabatic passage that is robust against control parameter variations. The all-optical, robust, and fast protocol demonstrated here provides an efficient and practical way to control quantum systems.
description: 8 pages, 5 figures, comments and suggestion are welcome
New Search for Monochromatic Neutrinos from Dark Matter Decay
Creators: name: Aisati, Chaïmae El
name: Gustafsson, Michael
name: Hambye, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: From data recently reported from the IceCube telescope, we derive new bounds on the monochromatic neutrino signal produced from dark matter particle decays. In the few TeV to tens of TeV energy range, these bounds turn out to be better than previous limits by more than an order of magnitude. As a result, intensity constraints on neutrino lines at energies above a few TeV are now comparable to those on gamma-ray lines. From the same data sample, we also perform a detailed search for a neutrino line, showing that there is no significant hint for such a signal.
description: 12 pages, 13 figures. Tabulated results attached among the source files (Appendix_D_Table.dat)
Note on a theorem of Bangert
Creators: name: Li, Tian-Jun
name: Wu, Weiwei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Symplectic Geometry (math.SG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 58D10, 32Q45, 53D45

description: We generalize Bangert's non-hyperbolicity result for uniformly tamed almost complex structures on standard symplectic $R^{2n}$ to asymtotically standard symplectic manifolds.
description: 11 pages
Bidirectional conversion between microwave and light via ferromagnetic magnons
Creators: name: Hisatomi, Ryusuke
name: Osada, Alto
name: Tabuchi, Yutaka
name: Ishikawa, Toyofumi
name: Noguchi, Atsushi
name: Yamazaki, Rekishu
name: Usami, Koji
name: Nakamura, Yasunobu
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Coherent conversion of microwave and optical photons in the single-quantum level can significantly expand our ability to process signals in various fields. Efficient up-conversion of a feeble signal in the microwave domain to the optical domain will lead to quantum-noise-limited microwave amplifiers. Coherent exchange between optical photons and microwave photons will also be a stepping stone to realize long-distance quantum communication. Here we demonstrate bidirectional and coherent conversion between microwave and light using collective spin excitations in a ferromagnet. The converter consists of two harmonic oscillator modes, a microwave cavity mode and a magnetostatic mode called Kittel mode, where microwave photons and magnons in the respective modes are strongly coupled and hybridized. An itinerant microwave field and a travelling optical field can be coupled through the hybrid system, where the microwave field is coupled to the hybrid system through the cavity mode, while the optical field addresses the hybrid system through the Kittel mode via Faraday and inverse Faraday effects. The conversion efficiency is theoretically analyzed and experimentally evaluated. The possible schemes for improving the efficiency are also discussed.
description: 15 pages, 8 figures
Crafting life for health and wellbeing: Understanding different types of crafting in everyday life
Creators: name: Ho, Kang Leng
name: De Bloom, Jessica
name: Bauer, Georg
name: Kerksieck, Philipp
name: Morstatt, Anja
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychiatry and Psychology
subject: Public Health
subject: Other Medicine and Health Sciences
subject: Medicine and Health Sciences
subject: Mental and Social Health
subject: Social and Behavioral Sciences

description: Pre-registration for Ecological Momentary Assessment (EMA) study about crafting across life domains during working days
National youth sedentary behavior and physical activity daily patterns using latent class analysis applied to accelerometry
Creators: name: Wen, Fang
name: Hales, Derek
name: Evenson, Kelly
name: Herring, Amy
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background Applying latent class analysis (LCA) to accelerometry can help elucidated underlying patterns. This study described the patterns of accelerometer-determined sedentary behavior and physical activity among youth by applying LCA to a nationally representative United States (US) sample. Methods Using 2003–2006 National Health and Nutrition Examination Survey data, 3998 youths 6–17 years wore an ActiGraph 7164 accelerometer for one week, providing > =3 days of wear for > =8 h/day from 6:00 am-midnight. Cutpoints defined sedentary behavior (<100 counts/minute), light activity (100–2295 counts/minute), moderate to vigorous physical activity (MVPA; > = 2296 counts/minute), and vigorous activity (> = 4012 counts/minute). To account for wear time differences, outcomes were expressed as percent of day in a given intensity. LCA was used to classify daily (Monday through Sunday) patterns of average counts/minute, sedentary behavior, light activity, MVPA, and vigorous activity separately. The latent classes were explored overall and by age (6–11, 12–14, 15–17 years), gender, and whether or not youth attended school during measurement. Estimates were weighted to account for the sampling frame. Results For average counts/minute/day, four classes emerged from least to most active: 40.9 % of population (mean 323.5 counts/minute/day), 40.3 % (559.6 counts/minute/day), 16.5 % (810.0 counts/minute/day), and 2.3 % (1132.9 counts/minute/day). For percent of sedentary behavior, four classes emerged: 13.5 % of population (mean 544.6 min/day), 30.1 % (455.1 min/day), 38.5 % (357.7 min/day), and 18.0 % (259.2 min/day). For percent of light activity, four classes emerged: 12.3 % of population (mean 222.6 min/day), 29.3 % (301.7 min/day), 41.8 % (384.0 min/day), and 16.6 % (455.5 min/day). For percent of MVPA, four classes emerged: 59.9 % of population (mean 25.0 min/day), 33.3 % (60.9 min/day), 3.1 % (89.0 min/day), and 3.6 % (109.3 min/day). For percent of vigorous activity, three classes emerged: 76.8 % of population (mean 7.1 min/day), 18.5 % (23.9 min/day), and 4.7 % (47.4 min/day). Classes were developed by age, gender, and school attendance since some patterns differed when stratifying by these factors. Conclusion The models supported patterns for average intensity, sedentary behavior, light activity, MVPA, and vigorous activity. These latent class derived patterns can be used in other youth studies to explore correlates or outcomes and to target sedentary behavior or physical activity interventions.
Procedure for automated generation of fluid-Poisson models for low-temperature plasma modelling
Creators: name: Stankov, Marjan
name: Jovanović, Aleksandar P.
name: Sigeneger, Florian
name: Loffhagen, Detlef
name: Becker, Markus M.
Publisher: name: Zenodo
Year: 2023
Subjects: plasma modelling
FEDM
MCPlas
Fluid model
COMSOL Multiphysics

description: Building a plasma model that takes into account the account a large number of particle species and reaction kinetic processes
 can be a tedious and error-prone process. A procedure for automated generation of spatio-temporal fluid-Poisson models suitable for low-temperature plasma modelling is developed and presented here. The proposed procedure automatically defines balance equations for the particle number densities and for the electron energy density, as well as the Poisson equation, based on the input data files. These files contain a list of the plasma species considered, their properties, and plasma-chemical reactions together with rate and transport coefficients. Also, information about modelling geometry and properties of the plasma source is part of the input data. A detailed input data structure and step-by-step instructions for implementing the proposed procedure are presented. The applicability of the procedure is demonstrated for the commercial software COMSOL Multiphysics and the open-source computing platform FEniCS. Using the example of an abnormal glow discharge in argon at 1 Torr, it is shown that the suggested procedure ensures reproducibility of the modelling procedure using different computing platforms.
description: Funded by the Deutsche Forschungsgemeinschaft (DFG) – project numbers: 504701852 and 466331904
description: {"references": ["COMSOL AB 2022 COMSOL Multiphysics\u00ae version. 6.1. Stockholm (www.comsol.com)", "FEniCS project (https://fenicsproject.org)", "A. P. Jovanovi\u0107 et al. IEEE Trans. Plasma Sci. 49 (2021) 3710", "https://github.com/INP-PM/FEDM", "A. P. Jovanovi\u0107 et al. Plasma Sources Sci. Technol. 32 (2023) 044003", "M. Stankov et al. Plasma Sources Sci. Technol. 31 (2022) 125002"]}
Stability of protein-based drugs: Herceptin a case study
Creators: name: Shropshire, Ian Michael
Publisher: name: University of Derby
Year: 2016
Subjects: Herceptin®
Trastuzumab
in use stability
physicochemical techniques
cellular assay

description: There is a lack of stability data for in-use parenteral drugs. Manufacturers state a shelf-life of 24 hours for infusions based on microbiological contamination. The lack of data is of particular significance with protein-based drugs where action is determined by their complex structure. A range of techniques are required to assess stability, including biological assessment to support other data. There has been an increase in published data but often the few studies that address in-use stability are incomplete as they do not employ biological assessment to assess potency. Trastuzumab is an antibody-based drug used to treat cancers where the Epidermal Growth Factor Receptor 2 (HER2) is over expressed or over abundant on the cell surface. Trastuzumab infusions have been assigned by the manufacturer to be stable for 24 hours at temperatures not exceeding 30 oC. If stability is shown beyond this point it would enable extended storage and administration. To this end, methods were selected and developed with biological assessment central to the approach to assess clinically relevant infusion concentrations (0.5 mg/mL and 6.0 mg/mL) and a sub-clinical infusion concentration (0.1 mg/mL). This may enhance instability and provide opportunity to study degradation. A Cell Counting Kit CCK8 (Sigma Aldrich) was ultimately adopted as a basis for a colorimetric assay to assess cell viability. Attenuated Total Reflectance Infra-Red Spectroscopy and Size Exclusion Chromatography methods were developed to evaluate secondary structure and aggregation respectively. These methods were applied to a shelf-life study (43 days) as a collaboration with Quality Control North West (NHS) and Clatterbridge Centre for Oncology NHS Foundation Trust, Clatterbridge Hospital. There was no evidence of degradation and no loss efficacy for clinically relevant infusions (0.5 mg/mL and 6.0 mg/mL) over 43 days, whilst the sub-clinical infusions (0.1 mg/mL) developed particles after 7 days of storage between 2 oC and 8 oC. Furthermore, evidence of stability at day 119 gave increased confidence for the data from earlier time points. This work assisted in the shelf-life being recommended to be extended to 28 days for Trastuzumab stored in polyolefin IV bags at concentrations between 0.5 mg/mL and 6.0 mg/mL with 0.9% saline between 2 oC and 8 oC. However, infusions with concentrations below 0.5 mg/mL were not recommended for storage.
EOSC integration plan
Creators: name: Kovács, József
name: Farkas, Attila
name: Sipos, Gergely
name: Lovas, Róbert
name: Pisa, Claudio
name: Papastefanatos, George
name: Peraki, Christina
name: Chondros, Nikos
Publisher: name: Zenodo
Year: 2020
Subjects: EOSC
service
integration
plan

description: NEANIAS develops thematic services for EOSC communities on the field of Underwater, Atmospheric and Space research. The project will integrate the thematic services into the EOSC ecosystem after they reach the maturity required by EOSC. This deliverable collects and introduces the integration approaches, procedures, relevant services discovered as part of the EOSC landscape. Based on this information the document then proposes an integration strategy and roadmap.
title: Imaging as a cornerstone before living donor liver transplantation
Creators: name: Garcia Alba, Carmen
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Liver
subject: CT
subject: MR
subject: Decision analysis
subject: Transplantation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Become familiar with imaging needed to select candidates to living liver donation Acknowledge all key features in morphologic evaluation of potential living liver donors and several considerations such as recipient’s age Comprehend the different...
Effective field theory approach to $b\to s\ell\ell^{(\prime)}$, $B\to K^{(*)}ν\barν$ and $B\to D^{(*)}τν$ with third generation couplings
Creators: name: Calibbi, Lorenzo
name: Crivellin, Andreas
name: Ota, Toshihiko
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: LHCb reported anomalies in $B\to K^* μ^+μ^-$, $B_s\toϕμ^+μ^-$ and $R(K)=B\to K μ^+μ^-/B\to K e^+e^-$. Furthermore, BaBar, BELLE and LHCb found hints for the violation of lepton flavour universality violation in $R(D^{(*)})=B\to D^{(*)}τν/B\to D^{(*)}\ellν$. In this note we reexamine these decays and their correlations to $B\to K^{(*)}ν\barν$ using gauge invariant dim-6 operators. For the numerical analysis we focus on scenarios in which new physics couples, in the interaction eigenbasis, to third generation quarks and lepton only. We conclude that such a setup can explain the $b\to sμ^+μ^-$ data simultaneously with $R(D^{(*)})$ for small mixing angles in the lepton sector (of the order of $π/16$) and very small mixing angles in the quark sector (smaller than $V_{cb}$). In these region of parameter space $B\to K^{(*)}τμ$ and $B_s\to τμ$ can be order $10^{-6}$. Possible UV completions are briefly discussed.
description: 7 pages, 3 figures
title: Low dose CT of the lumbar spine has better image quality than lumbar spine radiography at similar dose levels
Creators: name: Alshamari, Muhammed
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Quality assurance
subject: Physics
subject: Diagnostic procedure
subject: CT
subject: Conventional radiography
subject: Musculoskeletal spine

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Despite recent abundant evidence of the limited value of lumbar spine radiography (1,2), it is still the most common radiologic investigation of the lumbar spine region. Clinicians try to use conventional radiography as much as possible to avoid or...
Human resources requirements for highly active antiretroviral therapy scale-up in Malawi
Creators: name: Muula, Adamson S
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background Twelve percent of the adult population in Malawi is estimated to be HIV infected. About 15% to 20% of these are in need of life saving antiretroviral therapy. The country has a public sector-led antiretroviral treatment program both in the private and public health sectors. Estimation of the clinical human resources needs is required to inform the planning and distribution of health professionals. Methods We obtained data on the total number of patients on highly active antiretroviral treatment program from the Malawi National AIDS Commission and Ministry of Health, HIV Unit, and the number of registered health professionals from the relevant regulatory bodies. We also estimated number of health professionals required to deliver highly active antiretroviral therapy (HAART) using estimates of human resources from the literature. We also obtained data from the Ministry of Health on the actual number of nurses, clinical officers and medical doctors providing services in HAART clinics. We then made comparisons between the human resources situation on the ground and the theoretical estimates based on explicit assumptions. Results There were 610 clinicians (396 clinical officers and 214 physicians), 44 pharmacists and 98 pharmacy technicians and 7264 nurses registered in Malawi. At the end of March 2007 there were 85 clinical officer and physician full-time equivalents (FTEs) and 91 nurse FTEs providing HAART to 95,674 patients. The human resources used for the delivery of HAART comprised 13.9% of all clinical officers and physicians and 1.1% of all nurses. Using the estimated numbers of health professionals from the literature required 15.7–31.4% of all physicians and clinical officers, 66.5–199.3% of all pharmacists and pharmacy technicians and 2.6 to 9.2% of all the available nurses. To provide HAART to all the 170,000 HIV infected persons estimated as clinically eligible would require 4.7% to 16.4% of the total number of nurses, 118.1% to 354.2% of all the available pharmacists and pharmacy technicians and 27.9% to 55.7% of all clinical officers and physicians. The actual number of health professionals working in the delivery of HAART in the clinics represented 44% to 88.8% (for clinical officers and medical doctors) and 13.6% and 47.6% (for nurses), of what would have been needed based on the literature estimation. Conclusion HAART provision is a labour intensive exercise. Although these data are insufficient to determine whether HAART scale-up has resulted in the weakening or strengthening of the health systems in Malawi, the human resources requirements for HAART scale-up are significant. Malawi is using far less human resources than would be estimated based on the literature from other settings. The impact of HAART scale-up on the overall delivery of health services should be assessed.
TAPAS - Tracking Advanced Planetary Systems with HARPS-N. II. Super Li-rich giant HD 107028
Creators: name: Adamow, M.
name: Niedzielski, A.
name: Villaver, E.
name: Wolszczan, A.
name: Kowalik, K.
name: Nowak, G.
name: Adamczyk, M.
name: Deka-Szymankiewicz, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Lithium rich giant stars are rare objects. For some of them, Li enrichment exceeds abundance of this element found in solar system meteorites, suggesting that these stars have gone through a Li enhancement process. We identified a Li rich giant HD 107028 with A(Li) > 3.3 in a sample of evolved stars observed within the PennState Torun Planet Search. In this work we study different enhancement scenarios and we try to identify the one responsible for Li enrichment for HD 107028. We collected high resolution spectra with three different instruments, covering different spectral ranges. We determine stellar parameters and abundances of selected elements with both equivalent width measurements and analysis, and spectral synthesis. We also collected multi epoch high precision radial velocities in an attempt to detect a companion. Collected data show that HD 107028 is a star at the base of Red Giant Branch. Except for high Li abundance, we have not identified any other anomalies in its chemical composition, and there is no indication of a low mass or stellar companion. We exclude Li production at the Luminosity Function Bump on RGB, as the effective temperature and luminosity suggest that the evolutionary state is much earlier than RGB Bump. We also cannot confirm the Li enhancement by contamination, as we do not observe any anomalies that are associated with this scenario. After evaluating various scenarios of Li enhancement we conclude that the Li-overabundance of HD 107028 originates from Main Sequence evolution, and may be caused by diffusion process.
description: Accepted for publication in A&A
Compact steep-spectrum sources as the parent population of flat-spectrum radio-loud NLS1s
Creators: name: Berton, Marco
name: Caccianiga, Alessandro
name: Foschini, Luigi
name: Peterson, Bradley M.
name: Mathur, Smita
name: Terreran, Giacomo
name: Ciroi, Stefano
name: Congiu, Enrico
name: Cracco, Valentina
name: Frezzato, Michele
name: La Mura, Giovanni
name: Rafanelli, Piero
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Narrow-line Seyfert 1 galaxies (NLS1s) are an interesting subclass of active galactic nuclei (AGN), which tipically does not exhibit any strong radio emission. Seven percent of them, though, are radio-loud and often show a flat radio-spectrum (F-NLS1s). This, along to the detection of $γ$-ray emission coming from them, is usually interpreted as a sign of a relativistic beamed jet oriented along the line of sight. An important aspect of these AGN that must be understood is the nature of their parent population, in other words how do they appear when observed under different angles. In the recent literature it has been proposed that a specific class of radio-galaxies, compact-steep sources (CSS) classified as high excitation radio galaxies (HERG), can represent the parent population of F-NLS1s. To test this hypothesis in a quantitative way,in this paper we analyzed the only two statistically complete samples of CSS/HERGs and F-NLS1s available in the literature. We derived the black hole mass and Eddington ratio distributions, and we built for the first time the radio luminosity function of F-NLS1s. Finally, we applied a relativistic beaming model to the luminosity function of CSS/HERGs, and compared the result with the observed function of F-NLS1s. We found that compact steep-spectrum sources are valid parent candidates and that F-NLS1s, when observed with a different inclination, might actually appear as CSS/HERGs.
description: 9 pages, 5 figures, 4 tables. Accepted for publication in Astronomy & Astrophysics
Climbing up the ranks: Do public managers with a professional background in their field of work prioritize professional quality?
Creators: name: Netra, Søren
name: Kristiansen, Mads
name: Grøn, Caroline
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Administration
subject: Public Affairs, Public Policy and Public Administration
subject: Leadership Studies
subject: Social and Behavioral Sciences
subject: Professional background, professional quality, education, leadership, management

description: Preregistration of secondary data analysis