title: Ð Ð¾Ð»Ñ Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½Ð° Î±V Ð¸ ÐºÐ°Ð»ÑÐ´ÐµÑÐ¼Ð¾Ð½Ð° Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ ÑÑÐ±ÐµÑÐºÑÐ»ÑÐ·Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The role of integrin Î±V and caldesmon in the development of tuberculosis
Creators: name: ÐÐ°ÑÐºÐµÐ»Ð¾Ð²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÐºÐ°Ð»ÑÐ´ÐµÑÐ¼Ð¾Ð½
Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½ Î±V
ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·
ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°
Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð°Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ°
Ð¼Ð°ÑÐºÐµÑÑ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°
ÑÐµÐ¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ñ
Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
ÑÐ¸Ð±ÑÐ¾Ð·
caldesmon
integrin Î±V
tuberculosis
degrees of tuberculosis activity
differential diagnosis
markers of tuberculosis
remodeling
reparation
inflammation
fibrosis

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð² Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½Ð° Î±V Ð¸ ÐºÐ°Ð»ÑÐ´ÐµÑÐ¼Ð¾Ð½Ð° (CaD) Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ðµ. ÐÑÐµÐ½Ð¸Ð²Ð°Ð»ÑÑ ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð² Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð² ÑÐ°ÐºÐ¸Ñ ÑÑÑÑÐºÑÑÑÐ°Ñ Ð¿Ð¾ÑÐ°Ð¶ÐµÐ½Ð½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸, ÐºÐ°Ðº Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ñ Ð¸ ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾-ÑÐºÐ°Ð½Ð½ÑÐ¹ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½Ñ. ÐÐ»Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»ÑÑ Ð¼ÐµÑÐ¾Ð´ Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð¿Ð¾ÐºÐ°Ð·Ð°Ð» Ð·Ð½Ð°ÑÐ¸Ð¼ÑÐµ ÑÐ°Ð·Ð»Ð¸ÑÐ¸Ñ ÑÑÐ¾Ð²Ð½Ñ CaD Ð² ÑÐ¾ÐµÐ´Ð¸Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾-ÑÐºÐ°Ð½Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐµ Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð´Ð»Ñ Ð³ÑÑÐ¿Ð¿ 1 Ð¸ 3. Ð£Ð²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ ÑÑÐ¾Ð²Ð½Ñ Ð±ÐµÐ»ÐºÐ° Ð² ÑÑÐ¾ÑÐ¾Ð½Ñ ÑÐµÐ¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐºÐ°Ð½Ð¸ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ ÑÐ²ÑÐ·Ð°Ð½Ð¾ Ñ ÑÑÐ°ÑÑÐ¸ÐµÐ¼ CaD Ð² Ð¼Ð¸Ð³ÑÐ°ÑÐ¸Ð¸, Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ð¸ ÐºÐ»ÐµÑÐ¾Ðº, Ð¿ÐµÑÐµÑÑÑÐ¾Ð¹ÐºÐµ Ð°ÐºÑÐ¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¸ÑÐ¾ÑÐºÐµÐ»ÐµÑÐ° Ð¿ÑÐ¸ Ð¿ÑÐ¾ÑÐµÑÑÐ°Ñ ÑÐµÐ¿Ð°ÑÐ°ÑÐ¸Ð¸ Ð¸ ÑÐ¸Ð±ÑÐ¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐºÐ°Ð½Ð¸. Ð£ÑÐ¾Ð²ÐµÐ½Ñ CaD Ð¾ÑÑÐ°Ð²Ð°Ð»ÑÑ Ð½ÐµÐ¸Ð·Ð¼ÐµÐ½Ð½ÑÐ¼ Ð² Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ðµ, ÑÑÐ¾ Ð¼Ð¾Ð¶ÐµÑ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²Ð¾Ð²Ð°ÑÑ Ð¾ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¸ ÑÐµÐ¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð°ÐºÑÐ¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¸ÑÐ¾ÑÐºÐµÐ»ÐµÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ð¸ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ»ÐµÑÐ¾Ðº Ð»ÐµÐ³ÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð¹ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð²Ð½Ðµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°. Ð£ÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ° Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½ Î±V Ð¾ÑÑÐ°Ð²Ð°Ð»ÑÑ Ð½ÐµÐ¸Ð·Ð¼ÐµÐ½Ð½ÑÐ¼ Ð² ÑÑÐµÐ½ÐºÐµ ÐºÐ°Ð²ÐµÑÐ½Ñ, ÑÑÐ¾ Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ ÑÐ²ÑÐ·Ð°Ð½Ð¾ Ñ ÑÑÐ°ÑÑÐ¸ÐµÐ¼ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐ¸Ð¿Ð¾Ð² Ð±ÐµÐ»ÐºÐ¾Ð² ÑÐµÐ¼ÐµÐ¹ÑÑÐ²Ð° Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½Ð¾Ð² Ð½Ð° ÐºÐ°Ð¶Ð´Ð¾Ð¼ Ð¸Ð· ÑÑÐ°Ð¿Ð¾Ð² ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸Ð±ÑÐ¾Ð·Ð½Ð¾Ð¹ ÐºÐ°Ð¿ÑÑÐ»Ñ. Ð Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ðµ Ð½Ð°Ð±Ð»ÑÐ´Ð°Ð»Ð¾ÑÑ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½Ð° Î±V Ð½Ð° ÑÑÐ°Ð¿Ðµ ÑÑÐ±ÑÐµÐ²Ð°Ð½Ð¸Ñ. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑ Ð¿ÑÐµÐ´Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÑ, ÑÑÐ¾ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ ÑÑÐ¾Ð²Ð½ÐµÐ¹ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð² CaD Ð¸ Ð¸Ð½ÑÐµÐ³ÑÐ¸Ð½Ð° Î±V Ð² Ð»ÐµÐ³Ð¾ÑÐ½ÑÑ ÑÐºÐ°Ð½ÑÑ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¼Ð¾Ð¶ÐµÑ Ð±ÑÑÑ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐ¼ Ð² Ð¿ÑÐµÐ´Ð¸ÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¾Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð°ÑÐºÐµÑÐ¾Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°.
description: This work is devoted to the study of proteins integrin Î±V and caldesmon (CaD) in tuberculosis lung disease. The level of proteins expression was assessed depending on the reparative and inflammation processes in granulomas and connective tissue component. The method of immunohistochemical research was used to carry out this work. Statistical analysis of the results showed significant differences in the CaD level in the connective tissue component depending on the reparative process characteristics for groups 1 and 3. An increase in the protein level towards tissue remodeling may be associated with the participation of CaD in migration, cell proliferation, and restructuring of the actin cytoskeleton during tissue repair and fibrosis processes. The CaD level remained unchanged in the granuloma, which may indicate a violation of the reorganization of the actin cytoskeleton, as well as a decrease in the functional activity of lung cells in tuberculosis pathology, regardless of the degree of the inflammatory process. The expression level of the integrin Î±V protein remained unchanged in the lung cavity, which may be due to the participation of various types of the integrin family proteins at each stage of the formation of the fibrous capsule. An increase in Î±V integrin was observed in the granuloma at the scarring stage. Thus, the obtained changes in the expression levels of CaD and Î±V integrin proteins in the lung tissues can be promising in predictive diagnosis as prognostic markers of the development of the tuberculosis process.