cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Outcomes of Ampicillin plus Azithromycin to Prolong Latency Period in Preterm Premature Rupture of Membranes between 24 and 33+6 Weeks of Gestation at King Chulalongkorn Memorial Hospital
Creators: name: Nannapat Sinrat
Publisher: name: PIMDEE Co., Ltd.
Year: 2020
Subjects: antibiotic
azithromycin
premature rupture of membrane
prolong latency period

description: Thai Journal of Obstetrics and Gynaecology, 28, 3, 175-182
Low-Level ionizing radiation induces selective killing of HIV-1-infected cells with reversal of cytokine induction using mtor inhibitors
Creators: name: Vo, T.T.
name: Evans, M.K.
name: Iordanskiy, S.
name: Kashanchi, F.
name: Kim, Y.
name: Noren Hooten, N.
name: Cowen, M.
name: Pinto, D.O.
name: Heredia, A.
name: DeMarino, C.
name: Batrakova, E.V.
name: Barclay, R.A.
name: Pleet, M.L.
Publisher: name: MDPI AG
Year: 2020

description: HIV-1 infects 39.5 million people worldwide, and cART is effective in preventing viral spread by reducing HIV-1 plasma viral loads to undetectable levels. However, viral reservoirs persist by mechanisms, including the inhibition of autophagy by HIV-1 proteins (i.e., Nef and Tat). HIV-1 reservoirs can be targeted by the “shock and kill” strategy, which utilizes latency-reversing agents (LRAs) to activate latent proviruses and immunotarget the virus-producing cells. Yet, limitations include reduced LRA permeability across anatomical barriers and immune hyper-activation. Ionizing radiation (IR) induces effective viral activation across anatomical barriers. Like other LRAs, IR may cause inflammation and modulate the secretion of extracellular vesicles (EVs). We and others have shown that cells may secrete cytokines and viral proteins in EVs and, therefore, LRAs may contribute to inflammatory EVs. In the present study, we mitigated the effects of IR-induced inflammatory EVs (i.e., TNF-α), through the use of mTOR inhibitors (mTORi; Rapamycin and INK128). Further, mTORi were found to enhance the selective killing of HIV-1-infected myeloid and T-cell reservoirs at the exclusion of uninfected cells, potentially via inhibition of viral transcription/translation and induction of autophagy. Collectively, the proposed regimen using cART, IR, and mTORi presents a novel approach allowing for the targeting of viral reservoirs, prevention of immune hyper-activation, and selectively killing latently infected HIV-1 cells.
TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease
Creators: name: Batrakova, E.V.
name: Haney, M.J.
name: Harrison, E.B.
name: Zhao, Y.
name: Klyachko, N.L.
name: Kabanov, A.V.
Publisher: name: Wiley-VCH Verlag
Year: 2019

description: Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage-derived EVs for brain delivery of a soluble lysosomal enzyme tripeptidyl peptidase-1, TPP1, to treat a lysosomal storage disorder, Neuronal Ceroid Lipofuscinoses 2 (CLN2) or Batten disease, is investigated. TPP1 is loaded into EVs using two methods: i) transfection of parental EV-producing macrophages with TPP1-encoding plasmid DNA (pDNA) or ii) incorporation therapeutic protein TPP1 into naive empty EVs. For the former approach, EVs released by pretransfected macrophages contain the active enzyme and TPP1-encoding pDNA. To achieve high loading efficiency by the latter approach, sonication or permeabilization of EV membranes with saponin is utilized. Both methods provide proficient incorporation of functional TPP1 into EVs (EV-TPP1). EVs significantly increase stability of TPP1 against protease degradation and provide efficient TPP1 delivery to target cells in in vitro model of CLN2. The majority of EV-TPP1 (≈70%) is delivered to target organelles, lysosomes. Finally, a robust brain accumulation of EV carriers and increased lifespan is recorded in late-infantile neuronal ceroid lipofuscinosis (LINCL) mouse model following intraperitoneal administration of EV-TPP1.
Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer
Creators: name: Wayne, E.C.
name: Kabanov, A.V.
name: Parise, L.V.
name: Leisner, T.M..
name: Haney, M.J.
name: Long, C.
name: Batrakova, E.V.
Publisher: name: John Wiley and Sons Inc.
Year: 2019

description: Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This study examines the ability of macrophages to horizontally transfer small interfering RNA (siRNA) lipoplexes to cancer cells. Macrophages are a natural candidate for a drug carrier because of their ability to accumulate at high densities into many cancer types, including, breast, prostate, brain, and colon cancer. Here, it is demonstrated that macrophages can horizontally transfer siRNA to cancer cells during in vitro coculture. The amount of transfer can be dosed depending on the amount of siRNA loaded and total number of macrophages delivered. Macrophages loaded with calcium integrin binding protein-1 (CIB1)-siRNA result in decreased tumorsphere growth and decreased mRNA expression of CIB1 and KI67 in MDA-MB-468 human breast cancer cells. Adoptive transfer of macrophages transfected with CIB1-siRNA localizes to the orthotopic MDA-MB-468 tumor. Furthermore, it is reported that macrophage activation can modulate this transfer process as well as intracellular trafficking protein Rab27a. As macrophages are heavily involved in tumor progression, understanding how to use macrophages for drug delivery can substantially benefit the treatment of tumors.
GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice
Creators: name: Lee, Y.Z.
name: Fine, J.P.
name: El-Hage, N.
name: Batrakova, E.V.
name: Uvarov, O.
name: Langworthy, B.
name: Kabanov, A.V.
name: Rodriguez, M.
name: Haney, M.J.
name: Zhao, Y.
name: Jin, Y.S.
name: Vinod, N.
Publisher: name: Elsevier B.V.
Year: 2019

description: There is an unmet medical need in the area of Parkinson's disease (PD) to develop novel therapeutic approaches that can stop and reverse the underlying mechanisms responsible for the neuronal death. We previously demonstrated that systemically administered autologous macrophages transfected ex vivo to produce glial cell line-derived neurotrophic factor (GDNF) readily migrate to the mouse brain with acute toxin-induced neuroinflammation and ameliorate neurodegeneration in PD mouse models. We hypothesized that the high level of cytokines due to inflammatory process attracted GDNF-expressing macrophages and ensured targeted drug delivery to the PD brain. Herein, we validated a therapeutic potential of GDNF-transfected macrophages in a transgenic Parkin Q311X(A) mice with slow progression and mild brain inflammation. Systemic administration of GDNF-macrophages at a severe late stage of the disease leaded to a near complete restoration of motor functions in Parkin Q311X(A) mice and improved brain tissue integrity with healthy neuronal morphology. Furthermore, intravenous injections of GDNF-macrophages at an early stage of disease resulted in potent sustained therapeutic effects in PD mice for more than a year after the treatment. Importantly, multiple lines of evidence for therapeutic efficacy were observed including: diminished neuroinflammation and α-synuclein aggregation, increased survival of dopaminergic neurons, and improved locomotor functions. In summary, GDNF-transfected macrophages represent a promising therapeutic strategy for PD at both late- and early-stages of the disease.
Resonance width distribution in RMT: Weak coupling regime beyond Porter-Thomas
Creators: name: Fyodorov, Yan V.
name: Savin, Dmitry V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We employ the random matrix theory (RMT) framework to revisit the distribution of resonance widths in quantum chaotic systems weakly coupled to the continuum via a finite number M of open channels. In contrast to the standard first-order perturbation theory treatment we do not a priory assume the resonance widths being small compared to the mean level spacing. We show that to the leading order in weak coupling the perturbative $χ^2_M$ distribution of the resonance widths (in particular, the Porter-Thomas distribution at M=1) should be corrected by a factor related to a certain average of the ratio of square roots of the characteristic polynomial ("spectral determinant") of the underlying RMT Hamiltonian. A simple single-channel expression is obtained that properly approximates the width distribution also at large resonance overlap, where the Porter-Thomas result is no longer applicable.
description: 6 pages, 1 figure (minor corrections, typos fixed)
Additional file 1 of Transcriptome-wide identification of walnut PP2C family genes in response to external stimulus
Creators: name: Sisi, Chen
name: Jieru, Deng
name: Peidong, Cheng
name: Zhaolong, Zhang
name: Yihang, Wang
name: Shuwen, Chen
name: Yan, Tang
name: Tianyu, Wang
name: Guiyan, Yang
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. The primers used in the study.
Insights on localized and systemic delivery of redox-based therapeutics
Creators: name: Bahnson, E.S.M.
name: Buglak, N.E.
name: Batrakova, E.V.
name: Mota, R.
Publisher: name: Hindawi Limited
Year: 2018

description: Reactive oxygen and nitrogen species are indispensable in cellular physiology and signaling. Overproduction of these reactive species or failure to maintain their levels within the physiological range results in cellular redox dysfunction, often termed cellular oxidative stress. Redox dysfunction in turn is at the molecular basis of disease etiology and progression. Accordingly, antioxidant intervention to restore redox homeostasis has been pursued as a therapeutic strategy for cardiovascular disease, cancer, and neurodegenerative disorders among many others. Despite preliminary success in cellular and animal models, redoxbased interventions have virtually been ineffective in clinical trials. We propose the fundamental reason for their failure is a flawed delivery approach. Namely, systemic delivery for a geographically local disease limits the effectiveness of the antioxidant. We take a critical look at the literature and evaluate successful and unsuccessful approaches to translation of redox intervention to the clinical arena, including dose, patient selection, and delivery approach. We argue that when interpreting a failed antioxidant-based clinical trial, it is crucial to take into account these variables and importantly, whether the drug had an effect on the redox status. Finally, we propose that local and targeted delivery hold promise to translate redox-based therapies from the bench to the bedside.
Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain
Creators: name: Banks, W.A.
name: Bullock, K.M.
name: Haney, M.
name: Yuan, D.
name: Zhao, Y.
name: Kabanov, A.V.
Publisher: name: Elsevier Ltd
Year: 2017

description: Recent work has stimulated interest in the use of exosomes as nanocarriers for delivery of small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the blood-brain barrier (BBB), exosomes were modified with brain homing peptides that target brain endothelium but likely to increase immune response. Here for the first time we demonstrate that there is no need for such modification to penetrate the BBB in mammals. The naïve macrophage (Mϕ) exosomes can utilize, 1) on the one hand, the integrin lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule 1 (ICAM-1), and, 2) on the other hand, the carbohydrate-binding C-type lectin receptors, to interact with brain microvessel endothelial cells comprising the BBB. Notably, upregulation of ICAM-1, a common process in inflammation, promotes Mϕ exosomes uptake in the BBB cells. We further demonstrate in vivo that naïve Mϕ exosomes, after intravenous (IV) administration, cross the BBB and deliver a cargo protein, the brain derived neurotrophic factor (BDNF), to the brain. This delivery is enhanced in the presence of brain inflammation, a condition often present in CNS diseases. Taken together, the findings are of interest to basic science and possible use of Mϕ-derived exosomes as nanocarriers for brain delivery of therapeutic proteins to treat CNS diseases.
Macrophages with cellular backpacks for targeted drug delivery to the brain
Creators: name: Zhao, Y.
name: Gomes Neto, R.J.
name: Haney, M.J.
name: Kabanov, A.V.
name: Batrakova, E.V.
name: Polak, R.
name: Rubner, M.F.
name: Hill, M.C.
name: Klyachko, N.L.
name: Cohen, R.E.
Publisher: name: Elsevier Ltd
Year: 2017

description: Most potent therapeutics are unable to cross the blood-brain barrier following systemic administration, which necessitates the development of unconventional, clinically applicable drug delivery systems. With the given challenges, biologically active vehicles are crucial to accomplishing this task. We now report a new method for drug delivery that utilizes living cells as vehicles for drug carriage across the blood brain barrier. Cellular backpacks, 7–10 μm diameter polymer patches of a few hundred nanometers in thickness, are a potentially interesting approach, because they can act as drug depots that travel with the cell-carrier, without being phagocytized. Backpacks loaded with a potent antioxidant, catalase, were attached to autologous macrophages and systemically administered into mice with brain inflammation. Using inflammatory response cells enabled targeted drug transport to the inflamed brain. Furthermore, catalase-loaded backpacks demonstrated potent therapeutic effects deactivating free radicals released by activated microglia in vitro. This approach for drug carriage and release can accelerate the development of new drug formulations for all the neurodegenerative disorders.
Development and regulation of exosome-based therapy products
Creators: name: Kim, M.S.
name: Batrakova, E.V.
Publisher: name: Wiley-Blackwell
Year: 2016

description: Recently, various innovative therapies involving the ex vivo manipulation and subsequent reintroduction of exosome-based therapeutics into humans have been developed and validated, although no exosome-based therapeutics have yet to be brought into the clinic. Exosomes are nanosized vesicles secreted by many cells that utilize them for cell-to-cell communications to facilitate transport of proteins and genetic material. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes offer distinct advantages that exceptionally position them as highly effective drug carriers. Additionally, exosomes can exert unique biological activity reflective of their origin that may be used for therapy of various diseases. In fact, exosomes have benefits of both synthetic nanocarriers and cell-mediated drug delivery systems, and avoid their limitations. This concise review highlights the recent developments in exosome-based drug delivery systems and the main regulatory considerations for using this type of therapeutic in clinic. WIREs Nanomed Nanobiotechnol 2016, 8:744–757. doi: 10.1002/wnan.1395. For further resources related to this article, please visit the WIREs website.
Additional file 1 of Systematic review of products with potential application for use in the control of Campylobacter spp. in organic and free-range broilers
Creators: name: Lassen, Brian
name: Helwigh, Birgitte
name: Kahl Petersen, Channie
name: Ellis-Iversen, Johanne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Search strings used in DTU Findit search too to find publications.
Additional file 2 of Systematic review of products with potential application for use in the control of Campylobacter spp. in organic and free-range broilers
Creators: name: Lassen, Brian
name: Helwigh, Birgitte
name: Kahl Petersen, Channie
name: Ellis-Iversen, Johanne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2. Descriptors used to evaluate the articles.
Blood-borne macrophage-neural cell interactions hitchhike on endosome networks for cell-based nanozyme brain delivery
Creators: name: Zhao, Y.
name: Kabanov, A.V.
name: Mosley, R.L.
name: Suresh, P.
name: Sokolsky-Papkov, M.
name: Gendelman, H.E.
name: Klyachko, N.L.
name: Batrakova, E.V.
name: Haney, M.J.
name: Kanmogne, G.D.
name: Kadiu, I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Background: Macrophage-carried nanoformulated catalase ('nanozyme) attenuates neuroinflammation and protects nigrostriatal neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. This is facilitated by effective enzyme transfer from blood-borne macrophages to adjacent endothelial cells and neurons leading to the decomposition of reactive oxygen species. Materials & methods: We examined the intra- and inter-cellular trafficking mechanisms of nanozymes by confocal microscopy. Improved neuronal survival mediated by nanozyme-loaded macrophages was demonstrated by fluorescence-activated cell sorting. Results: In macrophages, nanozymes were internalized mainly by clathrin-mediated endocytosis then trafficked to recycling endosomes. The enzyme is subsequently released in exosomes facilitated by bridging conduits. Nanozyme transfer from macrophages to adjacent cells by endocytosis-independent mechanisms diffusing broadly throughout the recipient cells. In contrast, macrophage-free nanozymes were localized in lysosomes following endocytic entry. Conclusion: Facilitated transfer of nanozyme from cell to cell can improve neuroprotection against oxidative stress commonly seen during neurodegenerative disease processes.
Carolina Valvassori a Francesco Guicciardini (26 febbraio 1911)
Creators: name: Valvassori Carolina
Publisher: name: Zenodo
Year: 2023
Subjects: Accademia dei Georgofili
Franceschinis Valvassori, Carolina
Guicciardini, Francesco
1911
Donne
Scienziate
Pregiudizi

description: Lettera di Carolina Franceschinis Valvassori a Francesco Guicciardini del 26 febbraio 1911. Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio, Busta 44, 7482. Natura: manoscritto. Consistenza: cc. 2
description: Digitalizzato come parte della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). https://www.georgofili.it/contenuti/riconoscere-il-merito-superare-i-pregiudizi-scienziate-ai-georgofili-1753-1911-mostra-in-rete/11369
Additional file 3 of Systematic review of products with potential application for use in the control of Campylobacter spp. in organic and free-range broilers
Creators: name: Lassen, Brian
name: Helwigh, Birgitte
name: Kahl Petersen, Channie
name: Ellis-Iversen, Johanne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 3. Defined criteria based on GRADE guidelines used for quality assessment of studies.
Matrix product state approach to a frustrated spin chain with long-range interactions
Creators: name: Li, Zhi-Hua
name: Wang, An-Min
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We make extensive simulations over a spin chain model that combines the frustrated $J_1\textrm{-}J_2$ spin chain and the long-range nonfrustrated $(-1)^{(r-1)}r^{-α}$ decay interactions through the variational matrix product state method for both finite and infinite lengths. We study both the ground state entanglement and phase diagram. We find that it is most entangled in the rotation invariant long-range ordered antiferromagnetic phase, where the entanglement scales approximately logarithmically. We determine the development of the Majudar-Ghosh point to a disorder line from entanglement. And we determine approximately the transition from the dimerized and incommensurate phase of the $J_1\textrm{-}J_2$ model to a decoupled phase by studying spin correlation and the dimerization order parameter. Some implications for entanglement in systems with long-range interactions are stated.
description: 8 pages, 8 figures
title: Catalogus Realis. XVII. Staatswissenschaften. [Teil 2]
Publisher: name: Philipps-Universität Marburg
Year: 2020
Subjects: Hassiaca
Library and information sciences
Bibliotheks- und Informationswissenschaft
Systematischer Katalog

description: Elektronische Reproduktion von: Catalogus Realis. XVII. Staatswissenschaften. [Teil 2] (Fortsetzung von Teil 1). - Stand: Dezember 2019. - Standort: Universität Marburg, Universitätsbibliothek. - Signatur: Sonderlesesaal. - Bemerkungen: Der Katalog verzeichnet in systematisch-sachlicher Ordnung den Bestand der Universitätsbibliothek Marburg von den Anfängen bis 1957. Später erworbene ältere Literatur ist hier nicht verzeichnet. Mit Hilfe dieses Katalogs ist die Suche nach Literatur zu bestimmten Inhalten und Themen möglich. – Zur Systematik: Die Signaturen der einzelnen Bücher und Zeitschriften geben die Ordnung des Bestands wieder. Alle Signaturen beginnen mit einer römischen Zahl von I (1) bis XX (20), die das jeweilige Fach (Theologie, Geschichte, Medizin usw.) bezeichnet. Die weitere Untergliederung ergibt sich aus den nachfolgenden Kleinbuchstaben und arabischen Zahlen. Beispiel: XVIa A 117. Die Großbuchstaben A, B und C sind nicht Teil der Systematik, sondern bezeichnen das Format der betreffenden Bände: A = Folio (großformatige Bände), B = Quart (mittelgroße Bände), C = Oktav (kleinformatige Bände). - Digitalisiert 2020
description: [Titelblatt: XVII Staatswissenschaften 8°-Format : 144 – 482] 5 1 B. Volkswirtschaft und Weltwirtschaft [Forts.] 8 - Sozialwissenschaft (Arbeitgeber/Arbeitnehmer, Marxismus, Fürsorge etc.) 37 33 - Verkehrswesen u. Finanzwesen (Waren- u. Geldhandel, Banken, Versicherungen, Finanzverwaltung etc.) 100 90 - Gewerbe, Kartelle, Polizeiwissenschaft, Statistik, Stiftungen, Kassen etc. 183 165 - Die arbeitenden Klassen (Arbeiterversicherung, Genossenschaften, Gewerkschaften etc.) 242 - Öffentliche Armen- und Jugendpflege (Toleranz, Gewissensfreiheit …) 316 290 C. Staatenpolitik [Diplomatie] 356 328 - Diplomatie (Politische Agenten, Politische Testamente) 356 - Allgemeines und Europa (200 – 209.) 360 332 - Römisches Reich deutscher Nationen (210 – 243.) 365 - - Deutschland (276 – 285.) 399 - Österreich (244 – 246.) 385 357 - Preußen (247 – 252.) 387 - Sachsen und Polen (253 – 257.) 389 - Übrige europäische Staaten (258 – 273.) 390 362 - Amerika &. Asien (275.) 399 - Afrika (286 – 289.) 401 [D.] Privat- und Betriebswirtschaftslehre 403 - Bibliographie, Geschichte, Lexika 407 - Gesamtdarstellungen 417 379 - Rechnungswesen, Kalkulation, Versicherung etc. 427 Kapselschriften (I – III) 428
Additional file 4 of Systematic review of products with potential application for use in the control of Campylobacter spp. in organic and free-range broilers
Creators: name: Lassen, Brian
name: Helwigh, Birgitte
name: Kahl Petersen, Channie
name: Ellis-Iversen, Johanne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 4. Full data of selection process. Step by step exclusion of the identified article. The steps corresponds to the steps in Fig. 1.
title: Catalogus Realis. XVIIa. Politikwissenschaften. XVIIb. Wirtschaftswissenschaften.
Creators: name: Philipps-Universität Marburg
Publisher: name: Philipps-Universität Marburg
Year: 2020
Subjects: Standortkatalog
Hassiaca
Library and information sciences
Bibliotheks- und Informationswissenschaft

description: Elektronische Reproduktion von: Catalogus Realis. XVIIa. Politikwissenschaften. XVIIb. Wirtschaftswissenschaften. - Stand: Dezember 2019. - Standort: Universität Marburg, Universitätsbibliothek. - Signatur: Sonderlesesaal. - Bemerkungen: Der vorliegende Band 80 des Realkataloges ist ein reiner Standortkatalog ohne systematische Ordnung. Der Realkatalog verzeichnet in systematisch-sachlicher Ordnung den Bestand der Universitätsbibliothek Marburg von den Anfängen bis 1957. Später erworbene ältere Literatur ist hier nicht verzeichnet. Mit Hilfe dieses Katalogs ist die Suche nach Literatur zu bestimmten Inhalten und Themen möglich. – Zur Systematik: Die Signaturen der einzelnen Bücher und Zeitschriften geben die Ordnung des Bestands wieder. Alle Signaturen beginnen mit einer römischen Zahl von I (1) bis XX (20), die das jeweilige Fach (Theologie, Geschichte, Medizin usw.) bezeichnet. Die weitere Untergliederung ergibt sich aus den nachfolgenden Kleinbuchstaben und arabischen Zahlen. Beispiel: XVIa A 117. Die Großbuchstaben A, B und C sind nicht Teil der Systematik, sondern bezeichnen das Format der betreffenden Bände: A = Folio (großformatige Bände), B = Quart (mittelgroße Bände), C = Oktav (kleinformatige Bände). - Digitalisiert 2020
description: XVIIa – Politikwissenschaften 5 1 - Allgemeines (Bibliographie, Lexika, Handbücher etc.) 6 - Zeitschriften und Schriftenreihen 10 - Monographien und sonstige Einzelwerke 40 XVIIb – Wirtschaftswissenschaften 134 130 - Allgemeines (Bibliographie, Einführungen, Handbücher etc.) 134 - Zeitschriften 138 - Monographien, Serien- und Sammelwerke 208 204 - - Allgemeines, Einführungen, Wirtschaftstheorie etc. 208 - - Kapitalismuskritik, Marxismus, Sozialismus, Kommunismus etc. 234 - - Marktwirtschaft (Konjunkturpolitik, Arbeitsmarktpolitik etc.) 248 - - Wirtschaftsgeschichte 285 - - Agrarwirtschaft 298 294 - - Industrie & Handwerk (Unternehmensführung, Arbeitgeberverbände etc.) 322 - - Berufsausbildung, Arbeitswelt, Sozialpolitik, Gewerkschaften etc. 342 - - Betriebswirtschaftslehre (auch Finanzwirtschaft) 370 - - Handelspolitik (Internationale Wirtschaftsbeziehungen, Groß- u. Einzelhandel etc.) 386 - - - Verkehrswesen 408 - - Finanzwissenschaft (Geldpolitik, Kreditwesen, Banken etc.) 422 418 - - - Versicherungswesen 450 - - - Steuerpolitik und Staatsfinanzen 468
Cross-linked antioxidant nanozymes for improved delivery to CNS
Creators: name: Li, S.
name: Klyachko, N.L.
name: Manickam, D.S.
name: Uglanova, S.V.
name: Brynskikh, A.M.
name: Higginbotham, S.M.
name: Kabanov, A.V.
name: Batrakova, E.V.
name: Bronich, T.K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Formulations of antioxidant enzymes, superoxide dismutase 1 (SOD1, also known as Cu/Zn SOD) and catalase were prepared by electrostatic coupling of enzymes with cationic block copolymers, polyethyleneimine-poly(ethylene glycol) or poly(L-lysine)-poly(ethylene glycol), followed by covalent cross-linking to stabilize nanoparticles (NPs). Different cross-linking strategies (using glutaraldehyde, bis-(sulfosuccinimidyl)suberate sodium salt or 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride with N-hydroxysulfosuccinimide) and reaction conditions (pH and polycation/protein charge ratio) were investigated that allowed immobilizing active enzymes in cross-linked NPs, termed "nanozymes." Bienzyme NPs, containing both SOD1 and catalase were also formulated. Formation of complexes was confirmed using denaturing gel electrophoresis and western blotting; physicochemical characterization was conducted using dynamic light scattering and atomic force microscopy. In vivo studies of 125I-labeled SOD1-containing nanozymes in mice demonstrated their increased stability in both blood and brain and increased accumulation in brain tissues, in comparison with non-cross-linked complexes and native SOD1. Future studies will evaluate the potential of these formulations for delivery of antioxidant enzymes to the central nervous system to attenuate oxidative stress associated with neurological diseases. From the Clinical Editor: Formulations of antioxidant enzyme complexes were demonstrated along with their increased stability in both blood and brain and increased accumulation in CNS tissue. Future studies will evaluate the potential of these formulations for antioxidant enzyme deliver to the CNS to attenuate oxidative stress in neurodegenerative diseases.
Schulgesangbuch für die allgemeinen Volksschulen des Kantons Bern
Creators: name: [s.n.]
Publisher: name: [Verlag nicht ermittelbar]; Stämpflische Buchdruckerei
Year: 1848

description: aus Auftrag der Erziehungsdirektion bearbeitet und herausgegeben von Joh. Rudolf Weber, Seminarlehrer in Münchenbuchsee
description: Probeheft zur Prüfung durch die Lehrer des Kantons Bern
description: 3 Abtheilungen in einem Band
Additional file 5 of Systematic review of products with potential application for use in the control of Campylobacter spp. in organic and free-range broilers
Creators: name: Lassen, Brian
name: Helwigh, Birgitte
name: Kahl Petersen, Channie
name: Ellis-Iversen, Johanne
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 5. Reduction of Campylobacter. List of articles before the final step in the review process (Fig. 1), the tested interventions and the effect of the interventions.
Cell-mediated drug delivery
Creators: name: Gendelman, H.E.
name: Batrakova, E.V.
name: Kabanov, A.V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Introduction: Drug targeting to sites of tissue injury, tumor or infection with limited toxicity is the goal for successful pharmaceutics. Immunocytes (including mononuclear phagocytes (dendritic cells, monocytes and macrophages), neutrophils and lymphocytes) are highly mobile; they can migrate across impermeable barriers and release their drug cargo at sites of infection or tissue injury. Thus, immune cells can be exploited as Trojan horses for drug delivery. Areas covered: This paper reviews how immunocytes laden with drugs can cross the blood-brain or blood-tumor barriers to facilitate treatments for infectious diseases, injury, cancer, or inflammatory diseases. The promises and perils of cell-mediated drug delivery are reviewed, with examples of how immunocytes can be harnessed to improve therapeutic end points. Expert opinion: Using cells as delivery vehicles enables targeted drug transport and prolonged circulation times, along with reductions in cell and tissue toxicities. Such systems for drug carriage and targeted release represent a new disease-combating strategy being applied to a spectrum of human disorders. The design of nanocarriers for cell-mediated drug delivery may differ from those used for conventional drug delivery systems; nevertheless, engaging different defense mechanisms in drug delivery may open new perspectives for the active delivery of drugs.
Death due to COVID-19 in a patient with diabetes, epilepsy, and gout comorbidities
Creators: name: Safdarian, Amir Reza
name: Momenzadeh, Kaveh
name: Kahe, Farima
name: Farhangnia, Pooya
name: Rezaei, Nima
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: There is evidence of increased incidence, rapid progression, and poor prognosis ofCOVID-19 in patients with underlying comorbidities such as diabetes and epilepsy.Developing effective treatment regimens for COVID-19 patients with multiple comorbiditiesis crucial, as patients' past medical history is an essential contributor topossible organ injuries in COVID-19 patients. Herein, we report a confirmed case ofCOVID-19 patient with a history of multiple underlying diseases, including diabetes,epilepsy, and gout. The patient developed multiple organ failure and died a weekafter intensive care unit (ICU) admission. Multiple organ failure is the most commoncause of death in COVID-19 patients.
High-resolution ALMA Observations of SDP.81. II. Molecular Clump Properties of a Lensed Submillimeter Galaxy at z=3.042
Creators: name: Hatsukade, Bunyo
name: Tamura, Yoichi
name: Iono, Daisuke
name: Matsuda, Yuichi
name: Hayashi, Masao
name: Oguri, Masamune
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present spatially-resolved properties of molecular gas and dust in a gravitationally-lensed submillimeter galaxy H-ATLAS J090311.6+003906 (SDP.81) at $z=3.042$ revealed by the Atacama Large Millimeter/submillimeter Array (ALMA). We identified 14 molecular clumps in the CO(5-4) line data, all with a spatial scale of $\sim$50-300 pc in the source plane. The surface density of molecular gas ($Σ_{\rm H_2}$) and star-formation rate ($Σ_{\rm SFR}$) of the clumps are more than three orders of magnitude higher than those found in local spiral galaxies. The clumps are placed in the `burst' sequence in the $Σ_{\rm H_2}$-$Σ_{\rm SFR}$ plane, suggesting that $z \sim 3$ molecular clumps follow the star-formation law derived for local starburst galaxies. With our gravitational lens model, the positions in the source plane are derived for the molecular clumps, dust clumps, and stellar components identified in the {\sl Hubble Space Telescope} image. The molecular and dust clumps coexist in a similar region over $\sim$2 kpc, while the stellar components are offset at most by $\sim$5 kpc. The molecular clumps have a systematic velocity gradient in the north-south direction, which may indicate a rotating gas disk. One possible scenario is that the components of molecular gas, dust, and stars are distributed in a several-kpc scale rotating disk, and the stellar emission is heavily obscured by dust in the central star-forming region. Alternatively, SDP.81 can be explained by a merging system, where dusty starbursts occur in the region where the two galaxies collide, surrounded by tidal features traced in the stellar components.
description: 7 pages, 3 figures, Accepted for publication in PASJ
Additional file 1 of Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
Creators: name: Feitzinger, Anna A.
name: Le, Anthony
name: Thompson, Ammon
name: Haseeb, Mehnoor
name: Murugesan, Mohan Koumar
name: Tang, Austin M.
name: Lott, Susan E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Flow chart of general experimental work flow of RNA extraction and DE analysis.
Study guide for isolated students: School of Business and Law: True stories, great tips from high achieving students who performed well during the lock-down
Creators: name: Szabo, Zsolt
Publisher: name: Central Queensland University. School of Business and Law
Year: 2020
Subjects: Online study guide for students - 2020
Students
Higher education
Online course delivery
COVID-19

description: This publication contains face-to-face students experience and successful initiatives to continue their studies during COVID-19 lockdown.
Interactions of biliary micelles with polar lipids and digestion products from milk
Creators: name: Clulow, Andrew
name: Tai, Patrick
name: Salim, Malinda
name: Eason, Thomas
name: Seibt, Susi
name: Ryan, Timothy
name: Everett, David
name: Boyd, Ben
Publisher: name: AgResearch
Year: 2023
Subjects: classificationCode: 320504
subject: Medical biochemistry - lipids

description: Milk or milk-like emulsions are our sole source of nutrition for the first six months of life, and milk lipids carry fat-soluble nutrients through the gut as well as providing most of the energy we consume from milk. The digestion and absorption of milk lipids and entrained nutrients is therefore crucial for infant survival and growth. Triglycerides make up 98% of milk lipids, with the remainder comprising polar lipids, including sphingomyelins.[1, 2] Bile salts and phospholipids in the intestinal fluids combine to form a colloidal sink into which the poorly-soluble lipid digestion products can partition and be absorbed at the intestinal walls.[3] This work describes small angle X-ray scattering (SAXS) studies into how the structures of biliary micelles change when they absorb milk polar lipids and triglyceride digestion products under intestinal conditions (Figure 1). Firstly, mixtures of fatty acids and monoglycerides were prepared that mimic the digestion products of human and bovine milk.[4] Structural changes occurring when the biliary micelles were mixed with the milk-mimicking digestion product mixtures were found to be dictated primarily by the type of lipid chains present, with a secondary effect observed on varying the pH between 6.3 and 7.7 to simulate passage down the intestinal tract. In a second study, the solubilisation of milk sphingomyelin-based vesicles by bile was investigated.[5] It was found that incorporation of increasing amounts of cholesterol led to the formation of multilamellar vesicles that were increasingly stabilised against absorption into the biliary micelles. This was observed through both retention of diffraction features from the multilamellar vesicles and commensurately reduced increases in the radii of gyration of the biliary micelles upon mixing with vesicle dispersions of higher cholesterol content.
Additional file 1 of Efficacy of conservative treatment for spastic cerebral palsy children with equinus gait: a systematic review and meta-analysis
Creators: name: Klaewkasikum, Krongkaew
name: Patathong, Tanyaporn
name: Woratanarat, Patarawan
name: Woratanarat, Thira
name: Thadanipon, Kunlawat
name: Rattanasiri, Sasivimol
name: Thakkinstian, Ammarin
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Neuroscience
Science Policy

description: Additional file 1. Search terms and search strategy.
$Ω_c γ\rightarrowΩ_c^\ast$ transition in lattice QCD
Creators: name: Bahtiyar, H.
name: Can, K. U.
name: Erkol, G.
name: Oka, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the electromagnetic $Ω_c γ\rightarrowΩ_c^\ast$ transition in 2+1 flavor lattice QCD, which gives access to the dominant decay mode of $Ω_c^\ast$ baryon. The magnetic dipole and the electric quadrupole transition form factors are computed. The magnetic dipole form factor is found to be mainly determined by the strange quark and the electric quadrupole form factor to be negligibly small, in consistency with the quark model. We also evaluate the helicity amplitudes and the decay rate.
description: 8 pages, 1 figure. Added references and discussion
Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells
Creators: name: Zhao, Y.
name: Han, H.-Y.
name: Higginbotham, S.M.
name: Gendelman, H.E.
name: Haney, M.J.
name: Mosley, R.L.
name: Booth, S.L.
name: Batrakova, E.V.
name: Li, S.
name: Kabanov, A.V.
name: Vetro, J.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Background: Our laboratories forged the concept of macrophage delivery of protein antioxidants to attenuate neuroinflammation and nigrostriatal neurodegeneration in Parkinsons disease. Notably, the delivery of the redox enzyme, catalase, incorporated into a polyion complex micelle ('nanozyme) by bone marrow-derived macrophages protected nigrostriatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. Nonetheless, how macrophage delivery of nanozyme increases the efficacy of catalase remains unknown. Methods: In this study, we examined the transfer of nanozyme from macrophages to brain microvessel endothelial cells, neurons and astrocytes. Results: Facilitated transport of the nanozyme from macrophages to endothelial, neuronal and glial target cells occurred through endocytosis-independent mechanisms that involved fusion of cellular membranes, macrophage bridging conduits and nanozyme lipid coatings. Nanozyme transfer was operative across an artificial blood-brain barrier and showed efficient reactive oxygen species decomposition. Conclusion: This is the first demonstration, to our knowledge, that drug-loaded macrophages discharge particles to contiguous target cells for therapeutic brain enzyme delivery. The data shown are of potential value for the treatment of neurodegenerative disorders and notably, Parkinsons disease.
Enabling Entrepreneurs to Build on their Means: The Effectual Decision-Making Canvas
Creators: name: González, Marcos
name: Terzidis, Orestis
name: Heblich, Benedict
Publisher: name: IEEEXplore
Year: 2022
Subjects: entrepreneurial decision-making
Effectuation
startups

description: Using the design science research approach and a framework for artifact development, this paper presents the design of an artifact in the field of entrepreneurship. More specifically, in the context of decision-making for early-stage entrepreneurs. In light of existing research indicating that the decision-making process significantly impacts an entrepreneur's effectiveness and that experienced entrepreneurs use Effectuation more often than Causation when reaching decisions, this paper presents a visual tool for assisting entrepreneurs in making decisions based on the principles of Effectuation. We finally test and evaluate the resulting "Effectual Decision-Making Canvas" with aspiring and practicing entrepreneurs.
Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles
Creators: name: Batrakova, E.V.
name: Zimmerman, M.C.
name: Gendelman, H.E.
name: Klyachko, N.L.
name: Booth, S.L.
name: Mosley, R.L.
name: Higginbotham, S.M.
name: Kabanov, A.V.
name: Jones, J.
name: Li, S.
name: Haney, M.J.
name: Zhao, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Background: We posit that cell-mediated drug delivery can improve transport of therapeutic enzymes to the brain and decrease inflammation and neurodegeneration seen during Parkinsons disease. Our prior works demonstrated that macrophages loaded with nanoformulated catalase ('nanozyme) then parenterally injected protect the nigrostriatum in a murine model of Parkinsons disease. Packaging of catalase into block ionomer complex with a synthetic polyelectrolyte block copolymer precludes enzyme degradation in macrophages. Methods: We examined relationships between the composition and structure of block ionomer complexes with a range of block copolymers, their physicochemical characteristics, and loading, release and catalase enzymatic activity in bone marrow-derived macrophages. Results: Formation of block ionomer complexes resulted in improved aggregation stability. Block ionomer complexes with -polylysine and poly(L-glutamic acid)-poly(ethylene glycol) demonstrated the least cytotoxicity and high loading and release rates. However, these formulations did not efficiently protect catalase inside macrophages. Conclusion: Nanozymes with polyethyleneimine- and poly(L-lysine) 10-poly(ethylene glycol) provided the best protection of enzymatic activity for cell-mediated drug delivery.
Additional file 3 of Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster
Creators: name: Feitzinger, Anna A.
name: Le, Anthony
name: Thompson, Ammon
name: Haseeb, Mehnoor
name: Murugesan, Mohan Koumar
name: Tang, Austin M.
name: Lott, Susan E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3. Description of the implementation of ZigZag for determining which genes are expressed in the embryos.
Parallel text index construction
Creators: name: Kurpicz, Florian
Publisher: name: Technische Universität Dortmund
Year: 2020
Subjects: subject: Parallel algorithms
subject: Shared memory
subject: Distributed memory
subject: Text index
subject: Wavelet tree
subject: Suffix array
subject: 004
subject: Paralleler Algorithmus
subject: Gemeinsamer Speicher
subject: Verteilter Speicher
subject: Wavelet
subject: Suffix Array

description: In dieser Dissertation betrachten wir die parallele Konstruktion von Text-Indizes. Text-Indizes stellen Zusatzinformationen über Texte bereit, die Anfragen hinsichtlich dieser Texte beschleunigen können. Ein Beispiel hierfür sind Volltext-Indizes, welche für eine effiziente Phrasensuche genutzt werden, also etwa für die Frage, ob eine Phrase in einem Text vorkommt oder nicht. Diese Dissertation befasst sich hauptsächlich, aber nicht ausschließlich mit der parallelen Konstruktion von Text-Indizes im geteilten und verteilten Speicher. Im ersten Teil der Dissertation betrachten wir Wavelet-Trees. Dabei handelt es sich um kompakte Indizes, welche Rank- und Select-Anfragen von binären Alphabeten auf Alphabete beliebiger Größe verallgemeinern. Im zweiten Teil der Dissertation betrachten wir das Suffix-Array, den am besten erforschten Text-Index überhaupt. Das Suffix-Array enthält die Startpositionen aller lexikografisch sortierten Suffixe eines Textes, d.h., wir möchten alle Suffixe eines Textes sortieren. Oft wird das Suffix-Array um das Longest-Common-Prefix-Array (LCP-Array) erweitert. Das LCP-Array enthält die Länge der längsten gemeinsamen Präfixe zweier lexikografisch konsekutiven Suffixe. Abschließend nutzen wir verteilte Suffix- und LCP-Arrays, um den Distributed-Patricia-Trie zu konstruieren. Dieser erlaubt es uns, verschiedene Phrase-Anfragen effizienter zu beantworten, als wenn wir nur das Suffix-Array nutzen.
description: The focus of this dissertation is the parallel construction of text indices. Text indices provide additional information about a text that allow to answer queries faster. Full-text indices for example are used to efficiently answer phrase queries, i.e., if and where a phrase occurs in a text. The research in this dissertation is focused on but not limited to parallel construction algorithms for text indices in both shared and distributed memory. In the first part, we look at wavelet trees: a compact index that generalizes rank and select queries from binary alphabets to alphabets of arbitrary size. In the second part of this dissertation, we consider the suffix array---one of the most researched text indices.The suffix array of a text contains the starting positions of the text's lexicographically sorted suffixes, i.e., we want to sort all its suffixes. Finally, we use the distributed suffix arrays (and LCP arrays) to compute distributed Patricia tries. This allows us to answer different phrase queries more efficiently than using only the suffix array.