cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Youth Activities Newsletter: Winter 1975
Creators: name: National Highway Traffic Safety Administration
Publisher: name: National Highway Traffic Safety Administration
publisherIdentifier: https://ror.org/04gcfqs37
publisherIdentifierScheme: ROR
Year: 1975
Subjects: classificationCode: https://trt.trb.org/term/91762
subject: Teenage drivers
classificationCode: https://trt.trb.org/term/91560
subject: Adolescents
classificationCode: https://trt.trb.org/term/90631
subject: Safety programs
classificationCode: https://trt.trb.org/term/90633
subject: Safety campaigns
classificationCode: https://trt.trb.org/term/90636
subject: Safety education
classificationCode: https://trt.trb.org/term/90601
subject: Traffic safety
classificationCode: https://trt.trb.org/term/90848
subject: Drunk driving
classificationCode: https://trt.trb.org/term/90847
subject: Intoxication
classificationCode: https://trt.trb.org/term/90683
subject: Crash causes
classificationCode: https://trt.trb.org/term/88911
subject: Laws and legislation
classificationCode: https://trt.trb.org/term/91709
subject: Advisory groups

description: Approximately 30% of all highway fatalities every year are youths between 15 and 24 years of age. The Youth Highway Safety Advisory Committee was organized by the Secretary of Transportation in 1970, to provide assistance to NHTSA in developing highway safety programs which would be effective in reducing accidents in this age group. A program designed to assist the States in establishing advisory and action groups at the State and local level was developed by the Committee. NHTSA Administrator James Gregory endorsed the concept and asked each State Governor to send two representatives to a conference in Scottsdale, Arizona, on March 29-31, 1974, at which the Committee's program was presented. Delegates from 47 States, the District of Columbia, Puerto Rico, and the Indian Nations attended the conference. As a follow-up to the conference, to create better communications in the area of youth highway safety activities, NHTSA decided to publish this newsletter. NHTSA believes that the exchange of information among the State and local youth leaders and within NHTSA will increase awareness of existing programs, foster new ideas, and involve more young people in the campaign for better highway safety.
Interactions between seedlings of the invasive tree Ailanthus altissima and the native tree Robinia pseudoacacia under low nutrient conditions
Creators: name: Nilsen, Erik T.
name: Bao, Zhe
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: The allelopathic effect of A. altissima and the nitrogen fixing ability of R. pseudoacacia make the interaction between these two species important to community dynamics. A replacement series greenhouse experiment was used to investigate the type of interaction between seedlings of A. altissima and R. pseudoacacia at high and low soil nutrition states. Also, seeds of A. altissima from its native (China) and invasive ranges (USA) were used to compare the effect of the different seed sources on the interaction with R. pseudoacacia. Robinia pseudoacacia was the better competitor. The presence of A. altissima significantly inhibited nodulation of R. pseudoacacia roots. In summary, in low nutrient early succession sites, seedlings of R. pseudoacacia and A. altissima will coexist and R. pseudoacacia will be the better competitor. However, A. altissima can increase its competitive ability by inhibiting nitrogen fixation by R. pseudoacacia. Differences between the competitive ability of the Chinese and US seed lots of A. altissima did not support the rapid evolution theory for invasive species success.
Estimating shadow price for symbiotic nitrogen and technical eﬃciency for legume-based conservation agriculture in Malawi
Creators: name: Khataza, Robertson R.B.
name: Hailu, Atakelty
name: Kragt, Marit E.
name: Doole, Graeme J.
name: Khataza, Robertson R.B.
name: Hailu, Atakelty
name: Kragt, Marit E.
name: Doole, Graeme J.
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: Farm Management
subject: Production Economics
subject: Africa
subject: biological nitrogen ﬁxation
subject: directional distance function
subject: eﬃciency and productivity
subject: sustainable agricultural intensiﬁcation

description: Determining the value of legumes as soil fertility amendments can be challenging, yet this information is required to guide public policy and to incentivise prescribed land-management practices such as conservation agriculture. We use a directional input distance function (DIDF) to estimate shadow prices for symbiotic nitrogen and the technical eﬃciency for mixed maize-legume production systems in Malawi. The shadow prices reﬂect the trade-oﬀ between fertiliser nitrogen and symbiotic nitrogen required to achieve a given quantity of output. Our results reveal considerable technical ineﬃciency in the production system. The estimated shadow prices vary across farms and are, on average, higher than the reference price for commercial nitrogen. The results suggest that it would be beneﬁcial to redesign the current price-support programs that subsidise chemical fertilisers and indirectly crowd-out organic soil amendments such as legumes.
Insights from Social Shaping Theory: The Appropriation of Large Language Models in an Undergraduate Programming Course
Creators: name: Padiyath, Aadarsh
name: Hou, Xinying
name: Pang, Amy
name: Vargas, Diego Viramontes
name: Gu, Xingjian
name: Nelson-Fromm, Tamara
name: Wu, Zihan
name: Guzdial, Mark
name: Ericson, Barbara
Publisher: name: arXiv
Year: 2024
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Artificial Intelligence (cs.AI)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: The capability of large language models (LLMs) to generate, debug, and explain code has sparked the interest of researchers and educators in undergraduate programming, with many anticipating their transformative potential in programming education. However, decisions about why and how to use LLMs in programming education may involve more than just the assessment of an LLM's technical capabilities. Using the social shaping of technology theory as a guiding framework, our study explores how students' social perceptions influence their own LLM usage. We then examine the correlation of self-reported LLM usage with students' self-efficacy and midterm performances in an undergraduate programming course. Triangulating data from an anonymous end-of-course student survey (n = 158), a mid-course self-efficacy survey (n=158), student interviews (n = 10), self-reported LLM usage on homework, and midterm performances, we discovered that students' use of LLMs was associated with their expectations for their future careers and their perceptions of peer usage. Additionally, early self-reported LLM usage in our context correlated with lower self-efficacy and lower midterm scores, while students' perceived over-reliance on LLMs, rather than their usage itself, correlated with decreased self-efficacy later in the course.
description: Accepted to the ACM Conference on International Computing Education Research V.1 (ICER '24 Vol. 1)
Overall review of curative impact and barriers of CAR-T cells in osteosarcoma
Creators: name: Li, Guilin
name: Wang, Hong
name: Meftahpour, Vafa
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2024
Subjects: CAR-T cell
osteosarcoma
HER2+
GD2

description: Osteosarcoma (OS) is a rare form of cancer and primary bone malignancy in children and adolescents. Current therapies include surgery, chemotherapy, and amputation. Therefore, a new therapeutic strategy is needed to dramatically change cancer treatment. Recently, chimeric antigen receptor T cells (CAR-T cells) have been of considerable interest as it has provided auspicious results and patients suffering from low side effects after injection that resolve with current therapy. However, there are reports that cytokine release storm (CRS) can be observed in some patients. In addition, as researchers have faced problems that limit and suppress T cells, further studies are required to resolve these problems. In addition, to maximize the therapeutic benefit of CAR-T cell therapy, researchers have suggested that combination therapy could be better used to treat cancer by overcoming any problems and reducing side effects as much as possible. This review summarizes these problems, barriers, and the results of some studies on the evaluation of CAR-T cells in patients with osteosarcoma.
description: EXCLI Journal; 23:Doc364; ISSN 1611-2156
Improved age determination of blood and teeth samples using a selected set of DNA methylation markers
Creators: name: Bekaert, Bram
name: Aubeline Kamalandua
name: Zapico, Sara C
name: Voorde, Wim Van De
name: Decorte, Ronny
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Chemistry
subject: Cancer
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences

description: Age estimation from DNA methylation markers has seen an exponential growth of interest, not in the least from forensic scientists. The current published assays, however, can still be improved by lowering the number of markers in the assay and by providing more accurate models to predict chronological age. From the published literature we selected 4 age-associated genes (ASPA, PDE4C, ELOVL2, and EDARADD) and determined CpG methylation levels from 206 blood samples of both deceased and living individuals (age range: 0–91 years). This data was subsequently used to compare prediction accuracy with both linear and non-linear regression models. A quadratic regression model in which the methylation levels of ELOVL2 were squared showed the highest accuracy with a Mean Absolute Deviation (MAD) between chronological age and predicted age of 3.75 years and an adjusted R2 of 0.95. No difference in accuracy was observed for samples obtained either from living and deceased individuals or between the 2 genders. In addition, 29 teeth from different individuals (age range: 19–70 years) were analyzed using the same set of markers resulting in a MAD of 4.86 years and an adjusted R2 of 0.74. Cross validation of the results obtained from blood samples demonstrated the robustness and reproducibility of the assay. In conclusion, the set of 4 CpG DNA methylation markers is capable of producing highly accurate age predictions for blood samples from deceased and living individuals
The perception and interpretation of Beethoven's piano sonatas in English and American publications of the nineteenth century
Creators: name: Gavenda, Victor
Publisher: name: The University of Texas at Austin
Year: 1983
Subjects: subject: Beethoven, Ludwig van, 1770-1827. Sonatas, piano
subject: Beethoven, Ludwig van, 1770-1827--Criticism and interpretation—History--19th century
subject: Musical criticism

description: This thesis presents the results of an investigation into how Beethoven's piano sonatas were reviewed and treated in musical journals and books on theory and piano playing published in England and America during the nineteenth century. The focus is not on Beethoven's sonatas themselves, but on the effect they had, and on the ways in which they were received, analyzed, and interpreted during this period. The thesis, therefore, falls within the parameters of two new fields of investigation to which musicological interest has turned in the past decade, particularly in Germany, namely Wirkungsgeschichte and Rezeptionsgeschichte
title: Région de Rabat. - Tendance nouvelle des formes d'habitat
title: Région de Rabat. - Tendance nouvelle des formes d'habitat
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Habitat

description: 66
description: 69
description: Bulletin économique et social du Maroc
description: Cartographie
description: BESM-carto_1956-69-p066-00_069-02
description: Source: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Source: Bulletin économique et social du Maroc
description: Source: Bulletin économique et social du Maroc (BESM) > BESM (Cartographie)
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/81893
description: Coverage: Maroc
description: Coverage: Rabat
description: Coverage: XXe siècle
description: Temporal: XXe siècle
description: Bibliographic citation: « Région de Rabat. - Tendance nouvelle des formes d'habitat », In Bulletin économique et social du Maroc (BESM), n° 69, 1956
description: Provenance: Maison méditerranéenne des sciences de l'homme, Cité numérique de la Méditerranée (Cinumed), Bibliothèque nationale du Royaume du Maroc (BNRM)
description: Provenance: https://cinumed.mmsh.univ-aix.fr/
Capoeta capoeta
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Capoeta
Capoeta capoeta

description: 119. Capoeta capoeta (Güldenstädt, 1773)
Common name. Transcaucasian barb
Taxonomy. Original description: Cyprinus capoeta Güldenstädt, 1773: 508, pl. 8 [Tiflis, Caspian Sea; No types known].
Revisions. None.
Illustrations. Zareian et al. (2018: 384, fig. 12).
Distribution in Iran. —Distribution in River Basin: Caspian Sea.—Distribution in Ecoregions: 434-Kura-South Caspian Drainages.
Status in Iran. [Native].—Siyah mahi-e Ghafghazi.—Listed in previous checklists from Iran by Esmaeili et al. (2017a); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iranian material: None.
Conservation. —IUCN: LC.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 42, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Revisiting revenue contingent loans for drought relief: government as risk manager
Creators: name: Botterill, Linda Courtenay
name: Chapman, Bruce
name: Kelly, Simon
name: Botterill, Linda Courtenay
name: Chapman, Bruce
name: Kelly, Simon
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: Farm Management
subject: revenue contingent loans
subject: drought
subject: equity

description: It is clear that Australian governments will provide assistance to farmers in drought, which is a rational political judgement supported by recent survey work suggesting strongly the pervasive existence among voters of agrarian sentiment. In this context, a reasonable question relates to what forms of assistance are most equitable for taxpayers and also have desirable properties for farm businesses. In this study it is argued that traditional and current approaches to drought assistance are not equitable and do not provide suﬃcient protection to farmers from default and thus insolvency risk. But there is an instrument available to government which can be designed to minimise taxpayer subsidies while at the same time delivering insurance for farmers against default: a Revenue Contingent Loan (RCL). Following the principles inherent in the Higher Education Contribution Scheme, a RCL is ﬁnancial assistance repaid contingent on a farm’s capacity to pay, meaning that loan defaults can be avoided. We model the revenue streams associated with a hypothetical loan of this type and illustrate the advantages for a farm business of these kinds of debt.
Adaptation responses to increasing drought frequency
Creators: name: Adamson, David
name: Loch, Adam
name: Schwabe, Kurt
name: Adamson, David
name: Loch, Adam
name: Schwabe, Kurt
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: Farm Management
subject: Land Economics/Use
subject: drought
subject: property rights
subject: state-contingent analysis
subject: water-use adaptation

description: Using state contingent analysis, we discuss how and why irrigators adapt to alternative water supply signals. Focusing on the timing of water allocations, we explore inherent diﬀerences in the demand for water by two key irrigation sectors: annual and perennial producers. The analysis explores the reliability of alternative water property right bundles and how reduced allocations across time inﬂuence alternative responses by producers. Our ﬁndings are then extended to explore how management strategies could adapt to two possible future drier state types: (i) where an average reduction in water supply is experienced; and (ii) where drought becomes more frequent. The combination of these ﬁndings is subsequently used to discuss the role water reform policy plays in dealing with current and future climate scenarios.
title: 03_0043
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Charge-modulated permeability and selectivity in graphdiyne for hydrogen purification
Creators: name: Tan, Xin
name: Liangzhi Kou
name: Tahini, Hassan A.
name: Smith, Sean C.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Using first-principle calculations, we show that injecting positive charges into graphdiyne can substantially improve its hydrogen purification capability. When positive charges are introduced, the H2 penetration barrier decreases while the penetration barriers of CO and CH4 are significantly increased, hence leading to enhanced permeability and selectivity for hydrogen purification from CO and CH4. These predictions show that application of positive charge provides a unique pathway, which avoids complicated synthesis routes, to enhance hydrogen purification performance, and may prove to be instrumental in searching for a new class of high-permeability and high-selectivity molecular-sieving membranes.
Charge-modulated permeability and selectivity in graphdiyne for hydrogen purification
Creators: name: Tan, Xin
name: Liangzhi Kou
name: Tahini, Hassan A.
name: Smith, Sean C.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Using first-principle calculations, we show that injecting positive charges into graphdiyne can substantially improve its hydrogen purification capability. When positive charges are introduced, the H2 penetration barrier decreases while the penetration barriers of CO and CH4 are significantly increased, hence leading to enhanced permeability and selectivity for hydrogen purification from CO and CH4. These predictions show that application of positive charge provides a unique pathway, which avoids complicated synthesis routes, to enhance hydrogen purification performance, and may prove to be instrumental in searching for a new class of high-permeability and high-selectivity molecular-sieving membranes.
Residual exhaled nitric oxide elevation in asthmatics is associated with eosinophilic chronic rhinosinusitis
Creators: name: Kobayashi, Yoshiki
name: Mikiya Asako
name: Ooka, Hisashi
name: Kanda, Akira
name: Tomoda, Koichi
name: Yasuba, Hirotaka
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Objective: Eosinophilic chronic rhinosinusitis (ECRS) is as a subgroup of chronic rhinosinusitis (CRS) with nasal polyps. ECRS is a refractory disease closely related to bronchial asthma. Fractionated exhaled nitric oxide (FeNO) levels were reportedly elevated in some asthmatics with CRS after adequate treatment, suggesting that residual eosinophilic airway inflammation or ECRS might affect FeNO levels. Methods: To investigate the association between asthma with ECRS and FeNO levels, we examined FeNO levels in 133 asthmatics (99 with ECRS and 34 without ECRS) and 13 patients with ECRS without asthma. The severity of asthma was defined by the Global Initiative for Asthma guidelines and that of sinusitis was evaluated by the sinus CT score based on the Lund–Mackay scale. Results and conclusions: FeNO levels were elevated even in well-controlled asthmatics with ECRS, whereas asthmatics without ECRS and ECRS patients without asthma did not have high FeNO levels (>50 ppb). Although FeNO levels were not correlated with asthma severity, they were positively correlated with the sinus CT score. In asthmatics with ECRS, patients with higher FeNO levels had more severe ECRS and asthma. There is a possibility of having comorbid ECRS, particularly in asthmatics with high FeNO levels even after adequate treatment, including ICS, suggesting that asthma and ECRS may be closely associated as one airway disease with eosinophilic inflammation. Continual awareness of the coexistent ECRS is ideally recommended for asthmatics with high FeNO levels.
Capoeta coadi Alwan, Zareian & Esmaeili 2016
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Capoeta
Capoeta coadi

description: 120. Capoeta coadi Alwan, Zareian & Esmaeili, 2016
Common name. Karun scraper-Coad’s scraper
Taxonomy. Original description: Capoeta coadi Alwan, Zareian & Esmaeili, 2016: 158, figs. 1-4 [Beshar (Bashar) River at Tale Gah village, Karun River drainage, Kohgiluyeh and Boyer Ahmad provinces, Iran, 30°47'27"N, 51°25'13"E; holotype: ZM-CBSU Z190].
Revisions. None.
Illustrations. Alwan et al. (2016: 158, fig. 1).
Distribution in Iran. —Distribution in River Basin: Tigris.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Endemic].—Siyah mahi-e Karun.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 42, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
The M2 muscarinic receptors are essential for signaling in the heart left ventricle during restraint stress in mice
Creators: name: Myslivecek, Jaromir
name: Tomankova, Hana
name: Valuskova, Paulina
name: Varejkova, Eva
name: Rotkova, Jana
name: Benes, Jan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Developmental Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: We hypothesized that muscarinic receptors (MRs) in the heart have a role in stress responses and thus investigated changes in MR signaling (gene expression, number of receptors, adenylyl cyclase (AC), phospholipase C (PLC), protein kinase A and C (PKA and PKC) and nitric oxide synthase [NOS]) in the left ventricle, together with telemetric measurement of heart rate (HR) in mice (wild type [WT] and M2 knockout [KO]) during and after one (1R) or seven sessions (7R) of restraint stress (seven mice per group). Stress decreased M2 MR mRNA and cell surface MR in the left ventricle in WT mice. In KO mice, 1R, but not 7R, decreased surface MR. Similarly, AC activity was decreased in WT mice after 1R and 7R, whereas in KO mice, there was no change. PLC activity was also decreased after 1R in WT and KO mice. This is in accord with the concept that cAMP is a key player in HR regulation. No change was found with stress in NOS activity. Amount of AC and PKA protein was not changed, but was altered for PKC isoenzymes (PKCα, β, γ, η and ε (increased) in KO mice, and PKCι (increased) in WT mice). KO mice were more susceptible to stress as shown by inability to compensate HR during 120 min following repeated stress. The results imply that not only M2 but also M3 are involved in stress signaling and in allostasis. We conclude that for a normal stress response, the expression of M2 MR to mediate vagal responses is essential.
Capoeta damascina
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Capoeta
Capoeta damascina

description: 121. Capoeta damascina (Valenciennes, 1842)
Common name. Mesopotamian barb
Taxonomy. Original description: Gobio damascinus Valenciennes in Cuvier & Valenciennes, 1842: 314, pl. 482 [Damascus, Syria; lectotype: MNHN 0000-4494; lectotype selected by Krupp & Schneider (1989: 365)].
Revisions. Alwan et al. (2016: 17).
Illustration. Valenciennes in Cuvier & Valenciennes (1842: pl. 482).
Distribution in Iran. —Distribution in River Basin: Tigris.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Native].—Siyah mahi-e Dameshghi.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Distribution in River Basin: Tigris.—Iran material: ZM-CBSU.
Conservation. —IUCN: LC.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on page 42, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
Improved age determination of blood and teeth samples using a selected set of DNA methylation markers
Creators: name: Bekaert, Bram
name: Aubeline Kamalandua
name: Zapico, Sara C
name: Voorde, Wim Van De
name: Decorte, Ronny
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Chemistry
subject: Cancer
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences

description: ABSTRACTAge estimation from DNA methylation markers has seen an exponential growth of interest, not in the least from forensic scientists. The current published assays, however, can still be improved by lowering the number of markers in the assay and by providing more accurate models to predict chronological age. From the published literature we selected 4 age-associated genes (ASPA, PDE4C, ELOVL2, and EDARADD) and determined CpG methylation levels from 206 blood samples of both deceased and living individuals (age range: 0–91 years). This data was subsequently used to compare prediction accuracy with both linear and non-linear regression models. A quadratic regression model in which the methylation levels of ELOVL2 were squared showed the highest accuracy with a Mean Absolute Deviation (MAD) between chronological age and predicted age of 3.75 years, a MAD of 3.09 years, and an adjusted R2 of 0.95. No difference in accuracy was observed for samples obtained either from living and deceased individuals or between the two genders. In addition, 29 teeth from different individuals (age range: 19–70 years) were analyzed using the same set of markers and regression model resulting in a MAD of 4.86 years and an adjusted R2 of 0.74. Cross validation of the results obtained from blood samples demonstrated the robustness and reproducibility of the assay. In conclusion, the set of 4 CpG DNA methylation markers is capable of producing highly accurate age predictions for blood samples from deceased and living individuals.
Acute restraint stress induces endothelial dysfunction: role of vasoconstrictor prostanoids and oxidative stress
Creators: name: Carda, Ana P. P.
name: Marchi, Katia C.
name: Rizzi, Elen
name: Mecawi, André S.
name: Antunes-Rodrigues, José
name: Padovan, Claudia M.
name: Tirapelli, Carlos R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Marine Biology
subject: Biological Sciences
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Physiology
subject: Cell Biology

description: We hypothesized that acute stress would induce endothelial dysfunction. Male Wistar rats were restrained for 2 h within wire mesh. Functional and biochemical analyses were conducted 24 h after the 2-h period of restraint. Stressed rats showed decreased exploration on the open arms of an elevated-plus maze (EPM) and increased plasma corticosterone concentration. Acute restraint stress did not alter systolic blood pressure, whereas it increased the in vitro contractile response to phenylephrine and serotonin in endothelium-intact rat aortas. NG-nitro-l-arginine methyl ester (l-NAME; nitric oxide synthase, NOS, inhibitor) did not alter the contraction induced by phenylephrine in aortic rings from stressed rats. Tiron, indomethacin and SQ29548 reversed the increase in the contractile response to phenylephrine induced by restraint stress. Increased systemic and vascular oxidative stress was evident in stressed rats. Restraint stress decreased plasma and vascular nitrate/nitrite (NOx) concentration and increased aortic expression of inducible (i) NOS, but not endothelial (e) NOS. Reduced expression of cyclooxygenase (COX)-1, but not COX-2, was observed in aortas from stressed rats. Restraint stress increased thromboxane (TX)B2 (stable TXA2 metabolite) concentration but did not affect prostaglandin (PG)F2α concentration in the aorta. Restraint reduced superoxide dismutase (SOD) activity, whereas concentrations of hydrogen peroxide (H2O2) and reduced glutathione (GSH) were not affected. The major new finding of our study is that restraint stress increases vascular contraction by an endothelium-dependent mechanism that involves increased oxidative stress and the generation of COX-derived vasoconstrictor prostanoids. Such stress-induced endothelial dysfunction could predispose to the development of cardiovascular diseases.
Early evacuation is the best bushﬁre risk mitigation strategy for south-eastern Australia
Creators: name: Venn, Tyron J.
name: Quiggin, John
name: Venn, Tyron J.
name: Quiggin, John
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agricultural and Food Policy
subject: Land Economics/Use
subject: Risk and Uncertainty
subject: bushﬁre
subject: economic eﬃciency
subject: evacuation
subject: home ignition zone
subject: prescribed ﬁre

description: Given the large and increasing bushﬁre threat to lives and property in Australia, there is a need for economic evaluation of risk mitigation policies that can be implemented by governments and homeowners. Three broad policies applicable for existing at-risk communities are evaluated: expanded use of landscape-scale prescribed ﬁre; home ignition zone treatment (bushﬁre defence sprinklers); and early evacuation when a bushﬁre is burning on extreme or catastrophic ﬁre danger days. Early evacuation is the only option that yields net economic beneﬁts relative to existing policy.
Long-term changes in the CA3 associative network of fear-conditioned mice
Creators: name: Albrecht, Anne
name: Richter-Levin, Gal
name: Heinemann, Uwe
name: Stork, Oliver
name: Çalışkan, Gürsel
name: Hollnagel, Jan O.
name: Rösler, Anton
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Neuroscience

description: The CA3 associative network plays a critical role in the generation of network activity patterns related to emotional state and fear memory. We investigated long-term changes in the corticosterone (CORT)-sensitive function of this network following fear conditioning and fear memory reactivation. In acute slice preparations from mice trained in either condition, the ratio of orthodromic population spike (PS) to antidromic PS was reduced compared to unconditioned animals, indicating a decrease in efficacy of neuronal coupling within the associative CA3 network. However, spontaneous sharp wave–ripples (SW-R), which are thought to arise from this network, remained unaltered. Following CORT application, we observed an increase in orthodromic PS and a normalization to control levels of their ratio to antidromic PS, while SW-R increased in slices of fear conditioned and fear reactivated mice, but not in slices of unconditioned controls. Together with our previous observations of altered hippocampal gamma activity under these learning paradigms, these data suggest that fear conditioning and fear reactivation lastingly alters the CORT-sensitive configuration of different network activity patterns generated by the CA3 associational network. Observed changes in the mRNA expression of receptors for glutamate, GABA and cannabinoids in the stratum pyramidale of area CA3 may provide a molecular mechanism for these adaptive changes.
title: How Effective is License Suspension and Revocation?
title: Traffic Tech: NHTSA Technology Transfer Series
titleType: AlternativeTitle
Creators: name: National Highway Traffic Safety Administration
Publisher: name: National Highway Traffic Safety Administration
publisherIdentifier: https://ror.org/04gcfqs37
publisherIdentifierScheme: ROR
Year: 1986
Subjects: classificationCode: https://trt.trb.org/term/88954
subject: Driver licenses
classificationCode: https://trt.trb.org/term/88957
subject: Suspensions
classificationCode: https://trt.trb.org/term/88956
subject: Revocation
classificationCode: https://trt.trb.org/term/91759
subject: Drunk drivers
classificationCode: https://trt.trb.org/term/91758
subject: Impaired drivers
classificationCode: https://trt.trb.org/term/90683
subject: Crash causes
classificationCode: https://trt.trb.org/term/90601
subject: Traffic safety

description: Perhaps the most effective administrative means of reducing the incidence of crashes involving DWI offenders is through driver license suspension or revocation. Because loss of the driving privilege is the ultimate means to controlling problem drivers, license suspension has a significant impact upon persons directly affected and also provides general deterrence to others who fear having their own license suspended. Research in four States (Alabama, California, North Carolina, and Washington) has documented a highly significant effect from this most basic of driver improvement actions.
Crossed molecular beam experiment for Sn + O2 reaction
Creators: name: Medvedkov, Iakov
name: Nikolayev, Anatoliy
name: Goettl, Shane
name: Yang, Zhenghai
name: Mebel, Alexander
name: Kaiser, Ralf
Publisher: name: Zenodo
Year: 2024

description: Time of flight data for LAD for the reaction of Sn + O2 (see .Excel for TOFs correspondence)

Data for isotope analysis abundance in Sn supersonic beam and for reactive scattering signal (Sn+O2 at center of mass), along with .ipynb scripts for its analysis
Role of nucleus of the solitary tract noradrenergic neurons in post-stress cardiovascular and hormonal control in male rats
Creators: name: Herman, James P.
name: Bundzikova-Osacka, Jana
name: Sriparna Ghosal
name: Packard, Benjamin A.
name: Ulrich-Lai, Yvonne M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111714 Mental Health
subject: Science Policy
subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cell Biology

description: Chronic stress causes hypothalamo–pituitary–adrenal (HPA) axis hyperactivity and cardiovascular dyshomeostasis. Noradrenergic (NA) neurons in the nucleus of the solitary tract (NTS) are considered to play a role in these changes. In this study, we tested the hypothesis that NTS NA A2 neurons are required for cardiovascular and HPA axis responses to both acute and chronic stress. Adult male rats received bilateral microinjection into the NTS of 6-hydroxydopamine (6-OHDA) to lesion A2 neurons [cardiovascular study, n = 5; HPA study, n = 5] or vehicle [cardiovascular study, n = 6; HPA study, n = 4]. Rats were exposed to acute restraint stress followed by 14 d of chronic variable stress (CVS). On the last day of testing, rats were placed in a novel elevated plus maze (EPM) to test post-CVS stress responses. Lesions of NTS A2 neurons reduced the tachycardic response to acute restraint, confirming that A2 neurons promote sympathetic activation following acute stress. In addition, CVS increased the ratio of low-frequency to high-frequency power for heart rate variability, indicative of sympathovagal imbalance, and this effect was significantly attenuated by 6-OHDA lesion. Lesions of NTS A2 neurons reduced acute restraint-induced corticosterone secretion, but did not affect the corticosterone response to the EPM, indicating that A2 neurons promote acute HPA axis responses, but are not involved in CVS-mediated HPA axis sensitization. Collectively, these data indicate that A2 neurons promote both cardiovascular and HPA axis responses to acute stress. Moreover, A2 catecholaminergic neurons may contribute to the potentially deleterious enhancement of sympathetic drive following chronic stress.
Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia
Creators: name: Wolthusen, Rick P.F.
name: Hass, Johanna
name: Walton, Esther
name: Turner, Jessica A.
name: Rössner, Veit
name: Sponheim, Scott R.
name: Beng-Choon Ho
name: Holt, Daphne J.
name: Gollub, Randy L.
name: Calhoun, Vince
name: Ehrlich, Stefan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Genetics
subject: FOS: Biological sciences

description: Objectives. Schizophrenia is a highly disabling psychiatric disorder with a heterogeneous phenotypic appearance. We aimed to further the understanding of some of the underlying genetics of schizophrenia, using left superior temporal gyrus (STG) grey matter thickness reduction as an endophenoptype in a genome-wide association (GWA) study. Methods. Structural magnetic resonance imaging (MRI) and genetic data of the Mind Clinical Imaging Consortium (MCIC) study of schizophrenia were used to analyse the interaction effects between 1,067,955 single nucleotide polymorphisms (SNPs) and disease status on left STG thickness in 126 healthy controls and 113 patients with schizophrenia. We next used a pathway approach to detect underlying pathophysiological pathways that may be related to schizophrenia. Results. No SNP by diagnosis interaction effect reached genome-wide significance (5 × 10–8) in our GWA study, but 10 SNPs reached P-values less than 10–6. The most prominent pathways included those involved in insulin, calcium, PI3K-Akt and MAPK signalling. Conclusions. Our strongest findings in the GWA study and pathway analysis point towards an involvement of glucose metabolism in left STG thickness reduction in patients with schizophrenia only. These results are in line with recently published studies, which showed an increased prevalence of psychosis among patients with metabolic syndrome-related illnesses including diabetes.
Behavioural assessment of pain in commercial turkeys (Meleagris gallopavo) with foot pad dermatitis
Creators: name: A. Sinclair
name: C. Weber Wyneken
name: T. Veldkamp
name: L.J. Vinco
name: P.M. Hocking
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Medicine

description: Two experiments were conducted to investigate the differences in susceptibility to foot pad dermatitis (FPD) of two medium-heavy lines of turkeys, and whether FPD is painful, by detailed analysis of behaviour in birds with and without analgesic treatment (betamethasone).Turkeys housed on dry litter in the first experiment generally had more frequent bouts of different behaviours that were of shorter duration than birds on wet litter. T-patterns (behavioural sequences) were more frequent, varied and complex on dry than on wet litter. Betamethasone-injected birds of line B, but not breed A, had shorter resting and longer standing durations on wet litter than saline-injected birds.In the second experiment, turkeys on wet litter given saline stood less and rested more than all other treatment groups, suggesting that they experienced pain that was alleviated in birds receiving betamethasone. Turkeys on dry litter had more frequent, varied and complex patterns of behaviour than turkeys on wet litter and birds kept on intermediate litter wetness. Betamethasone provision increased pattern variety regardless of litter treatment.Turkeys with low FPD scores transferred to wet litter and given saline injections had a longer total duration of resting and shorter duration of standing compared to betamethasone-treated birds. Low FPD birds transferred to wet litter had a similar number of patterns and total pattern occurrence as high FPD birds transferred to dry litter. Betamethasone increased pattern variety and frequency compared to saline injections whereas overall pattern complexity was similar.It was concluded that wet litter affects the behaviour of turkey poults independently of FPD and that betamethasone may also change the behaviour of turkeys. There was some evidence from analgesic treatment and T-pattern analyses that FPD was painful. However, there was no evidence of differences in susceptibility to FPD of the two commercial hybrids.
Reactions and products revealed by NMR spectra of deuterated dimethylsulfoxide with iodomethane in neutral and basic media
Creators: name: E. Avella-Moreno
name: N. Nuñez-Dallos
name: L. Garzón-Tovar
name: A. Duarte-Ruiz
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Hematology
Biological Sciences
Chemistry
Earth and Environmental Sciences
Physics
Biochemistry
Biophysics

description: Reactions occurring within each one of two mixtures, a mixture of deuterated dimethylsulfoxide, DMSO-d6, with CH3I (system I) and another mixture of DMSO-d6 with CH3I, NaOH and water (system II), were monitored by 1D and 2D nuclear magnetic resonance (1H, 13C, heteronuclear multiple quantum correlation, heteronuclear multiple bond correlation and diffusion-ordered NMR spectroscopy). The analysis of the spectra as a function of reaction time revealed the formation of methoxy-bis(trideuteromethyl)sulfonium iodide, 3; the precipitation of hexadeuterated trimethyloxosulfonium, 2a; a methyl exchange between DMSO-d6 and 2a to produce trideuterated dimethylsulfoxide, DMSO-d3, 4, and nona-deuterated trimethyloxosulfonium iodide, 2b; and the production of small quantities of methanol, 5, trideuterated dimethylsulfide, 6, and dimethyl ether, 7, in both systems. Only system II precipitated deuterated [Na4(DMSO-dx)15][(I3)3I], 1a, a green solid with metallic shine that corresponds to an isotopomer of 1, which is produced by the self-assembly of DMSO and CH3I in the presence of NaOH and water.