cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Britain’s future strength, the health of elementary school children, 1867-1907 : a study in social policy, legislative action and government growth
Creators: name: Farson, Anthony Stuart
Publisher: name: University of British Columbia
Year: 2010

description: The major objective of this thesis is to throw new light on the problem of "how" and "why" the function of the State within society changed dramatically during the first few years of the twentieth century By concentrating on the Liberal Government's measures of 1906 to 1907 to improve the health of working-class children this thesis hopes to show that the role of men and their beliefs played a far more important part in the development of the "British Welfare State" than has hitherto been credited. By illustrating how the social, political, and economic condi tions of the period 1870 to 1900 affected the consciousness of individuals and groups, it attempts to explain why there was a delay between the time when the extent of poverty became intolerable and the time when measures were enacted to relieve the problem. Three major themes intertwine throughout this thesis. These are the cause of government growth; the changing status of working-class children; and measures to improve the health of the nation. Chapter One discusses the social, physical, and psychological factors which affected the health of children before 1880, and illustrates the high esteem in which working-class parents held their children. Chapter Two shows how middle class Britain attempted to deal with the problem of child health in the period before the end of the nineteenth century. Chapter Three attempts to explain "how" and "why" the physical condition of the British working class became a question of major political significance for the first time. Specifically it describes the nineteenth century origins of the "National Efficiency" movement, the part played by the movement in concentrating public attention on the physical condition of the working class, and discusses the blue-print for social action formulated by the Inter-departmental Committee on Physical Deterioration. The last chapter describes how the Liberal Government of Sir Henry Campbell-Bannerman began the enactment of this social blue-print. Their first step was an Act which allowed local education authorities to feed needy school children free of charge. This was soon followed by another Act which allowed local education authorities to require the medical examination of all children attending public elementary schools. Together these Acts began a process of long-term social planning in Britain.
Thermodynamic study of catalytically supported thermal combustion systems
Creators: name: Chen, Junjie
Publisher: name: figshare
Year: 2022
Subjects: subject: 90403 Chemical Engineering Design
subject: FOS: Chemical engineering
subject: 90499 Chemical Engineering not elsewhere classified
subject: 90402 Catalytic Process Engineering
subject: 91501 Computational Fluid Dynamics
subject: FOS: Other engineering and technologies
subject: 91502 Computational Heat Transfer
subject: 91505 Heat and Mass Transfer Operations

description: Chemical thermodynamics is the study of the interrelation of heat and work with chemical reactions or with physical changes of state within the confines of the laws of thermodynamics. Chemical thermodynamics involves not only laboratory measurements of various thermodynamic properties, but also the application of mathematical methods to the study of chemical questions and the spontaneity of processes. The structure of chemical thermodynamics is based on the first two laws of thermodynamics. Starting from the first and second laws of thermodynamics, four equations called the "fundamental equations of Gibbs" can be derived. From these four, a multitude of equations, relating the thermodynamic properties of the thermodynamic system can be derived using relatively simple mathematics. This outlines the mathematical framework of chemical thermodynamics. The primary objective of chemical thermodynamics is the establishment of a criterion for determination of the feasibility or spontaneity of a given transformation. In this manner, chemical thermodynamics is typically used to predict the energy exchanges that occur in the following processes: chemical reactions, phase changes, and the formation of solutions. The following state functions are of primary concern in chemical thermodynamics: internal energy, enthalpy, entropy, and Gibbs free energy. Most identities in chemical thermodynamics arise from application of the first and second laws of thermodynamics, particularly the law of conservation of energy, to these state functions. Chemical energy is the energy that can be released when chemical substances undergo a transformation through a chemical reaction. Breaking and making chemical bonds involves energy release or uptake, often as heat that may be either absorbed by or evolved from the chemical system. Contributor: Junjie Chen, ORCID: 0000-0001-5055-4309, E-mail address: komcjj@gmail.com, Department of Energy and Power Engineering, School of Mechanical and Power Engineering, Henan Polytechnic University, 2000 Century Avenue, Jiaozuo, Henan, 454000, P.R. China
Demography and dispersal in island and mainland populations of the deer mouse, Peromyscus maniculatus
Creators: name: Sullivan, Thomas Priestlay
Publisher: name: University of British Columbia
Year: 2010

description: If dispersal is reduced on islands, then the demography of island populations of deer mice should be different from that of mainland populations., Areas of 1.1 ha were periodically cleared of mice on Samuel Island (206 ha) and Saturna Island (3102 ha) in the Gulf Islands of southwestern British Columbia., A similar experiment was conducted on the mainland at Maple Ridge, B.C., The average density of mice per hectare on Saturna (43.5) was twice that on Samuel Island (22.0) and nearly two and one-half times higher than that on the mainland (18.7). The reproductive rate, as measured by length of breeding season, number of successful pregnancies, proportion of breeding animals, and number of recruits surviving to breed, was much higher on Samuel Island than on either Saturna or the mainland. Survival was lowest on Samuel Island, with little difference between the mainland and Saturna Island., Mice on Samuel Island grew more than five times faster than mainland animals, and Saturna growth rates were double those on the mainland. Island adult males showed very few aggressive tendencies in laboratory behaviour tests compared with the seasonal changes in aggression reported in the literature for mainland deer mice. Dispersal (or colonization) rate was reduced on the two islands compared with that on the mainland. Eecruitment of young animals occurred throughout the breeding season on the islands but was delayed until the end of breeding on the mainland. There was little difference in the demographic attributes of control populations when compared with those of colonist populations on either the mainland or the two islands. These results indicate that seasonal changes in aggressiveness of the adult population may be sufficient but not necessary to determine breeding density and seasonal changes in survival of juvenile deer mice., A more intensive study is reguired, but regulatory processes in populations of Peromy_scus oa&iculatus may be different on islands and perhaps should not be generalized over different geographic areas.
Unmixed Graphs that are Domains
Creators: name: Benedetti, Bruno
name: Varbaro, Matteo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Commutative Algebra (math.AC)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C70, 13A30

description: Given an arbitrary graph G, we study its basic covers algebra, which is the symbolic fiber cone of the Alexander dual of the edge ideal of G. Extending results of Villarreal and Benedetti-Constantinescu-Varbaro, valid only in the case when G is bipartite, we characterize in a combinatorial fashion the situations when: 1) the basic covers algebra is a domain, and 2) it is a domain and in addition (the edge ideal of) G is unmixed. It turns out that the last result gives a complete characterization of those graphs for which any symbolic power of the edge ideal is generated by monomials of the same degree.
description: Revised version, 8 pages
Efficacy of surface error corrections to density functional theory calculations of vacancy formation energy in transition metals
Creators: name: Nandi, Prithwish Kumar
name: Valsakumar, M. C.
name: Chandra, Sharat
name: Sahu, H. K.
name: Sundar, C. S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We calculate properties like equilibrium lattice parameter, bulk modulus and monovacancy formation energy for nickel (Ni), iron (Fe) and chromium (Cr) using Kohn-Sham density functional theory (DFT). We compare relative performance of local density approximation (LDA) and generalized gradient approximation (GGA) for predicting such physical properties for these metals. We also make a relative study between two different flavors of GGA exchange correlation functional, namely, PW91 and PBE. These calculations show that there is a discrepancy between DFT calculations and experimental data. In order to understand this discrepancy in the calculation of vacancy formation energy, we introduce a correction for the surface intrinsic error corresponding to an exchange correlation functional using the scheme implemented by Mattsson et al. [Phys. Rev. B 73, 195123 (2006)] and compare the effectiveness of the correction scheme for Al and the 3d-transition metals.
description: 29 pages, 3 figures, 5 tables, Published in J. Phys: Cond. Matt. vol.22 (2010) 345501
title: Реализация и апробация алгоритма для автоматизированного оперативного планирования расписания сеансов связи между космическими аппаратами и земными станциями
title: Implementation and Validation of Algorithm for Automated Operational Planning of Communication Sessions Between Spacecraft and Earth Stations
Creators: name: Старшинов, Владислав Сергеевич
name: Цапко, Сергей Геннадьевич
Publisher: name: Издательский центр СурГУ
Year: 2021

description: В статье проведен анализ распределения сеансов связи между космическими аппаратами и земными станциями в виде диаграмм активностей; реализован алгоритм, основанный на анализе бизнес-процессов управления космическими аппаратами; сформированы критерии оптимального сеанса связи. Программная реализация алгоритмов выполнена в среде Mathcad, позволяющей провести их апробацию с ограниченным количеством земных станций и космических аппаратов, создана имитационная модель распределения сеансов связи в среде AnyLogic. Полученные результаты программы для автоматизированного планирования расписания сеансов связи и имитационной модели распределения сеансов связи показали работоспособность алгоритма.
description: The paper considers the process of distribution of communication sessions between spacecraft and earth stations in the form of activity diagrams. To implement the algorithm, an analysis of the business processes of the distribution of communication sessions when controlling spacecraft between earth stations is made. The criteria for an optimal communication session are formed. The software implementation of the algorithms is performed in the Mathcad environment, which allows testing the obtained algorithms with a limited number of earth stations and spacecraft. For an adequate assessment of the obtained algorithm, additional validation is carried out in the AnyLogic simulation environment. The program results for the automated planning of communication sessions and the simulation model of the distribution of the session demonstrated the efficiency of the developed algorithm.
Host plant resistance to whitefly Trialeurodes vaporariorum in the genus Lycopersicon
Creators: name: Veilleux, Richard Ernest
Publisher: name: University of British Columbia
Year: 2010

description: The greenhouse whitefly (Trialeurodes vaporariorum) is one of the most destructive pests of greenhouse tomato (Lycopersicon esculentum) crops. The success of biological or insecticidal control of whiteflies has never been complete. Attention has therefore been directed recently to the possibility of developing tomato cultivars resistant to whiteflies. Whiteflies were caged on leaflets of ten tomato cultivars, two of the woolly mutant lines and four other species of Lycopersicon to observe the effect of host plants within this genus on fecundity and longevity of the insects. The results showed wide variation among hosts. Significant negative correlations were revealed between the mean density of glandular hairs on the upper foliar surface of different cultivars and means for the fecundity of whiteflies caged on these cultivars. A high level of resistance to whitefly, not related to density of glandular hairs, was observed in plants that were either Van Wert's woolly mutant or L. peruvianum var. humifusum. Resistance of the former seemed to be related to a high density of branched non-glandular trichornes whereas that of the latter was not morphologically apparent. There were indications of both antibiosis and nonpreference operating in the humifusum. Further experimentation revealed a high nymphal mortality for whiteflies developing on plants of this line, reduced fecundity of adults which had developed on the humifusum, and a preponderance of male progeny from adult insects which had lived exclusively on these plants. It was concluded that the resistance of L, peruvianum var. humifusum to whitefly is sufficient to justify its use in a breeding program to develop greenhouse tomato cultivars resistant to this pest.
Evidence of heavy-element ashes in thermonuclear X-ray bursts with photospheric superexpansion
Creators: name: Zand, J. J. M. in 't
name: Weinberg, N. N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A small subset of thermonuclear X-ray bursts on neutron stars exhibit such a strong photospheric expansion that for a few seconds the photosphere is located at a radius r_ph >~ 1000 km. Such `superexpansions' imply a large and rapid energy release, a feature characteristic of pure He burst models. Previous calculations have shown that during a pure He burst, the freshly synthesized heavy-element ashes of burning can be ejected in a strong radiative wind and produce significant spectral absorption features. We search the burst data catalogs and literature and find 32 superexpansion bursts. We find that these bursts exhibit the following interesting features: (1) At least 31 are from (candidate) ultracompact X-ray binaries in which the neutron star accretes hydrogen-deficient fuel, suggesting that these bursts indeed ignite in a helium-rich layer. (2) In 2 bursts we detect strong absorption edges during the expansion phase. The edge energies and depths are consistent with the H-like or He-like edge of iron-peak elements with abundances greater than 100 times solar, suggesting that we are seeing the exposed ashes of nuclear burning. (3) The superexpansion phase is always followed by a moderate expansion phase during which r_ph ~ 30 km and the luminosity is near the Eddington limit. (4) The decay time of the bursts, t_d, ranges from short (approximately 10 s) to intermediate (>~ 1000 s). However, despite the large range of t_d, the duration of the superexpansion is always a few seconds, independent of t_d. By contrast, the duration of the moderate expansion is always of order t_d. (5) The photospheric radii r_ph during the moderate expansion phase are much smaller than steady state wind models predict. We show that this may be further indication that the wind contains highly non-solar abundances of heavy elements.
description: Accepted for publication in Astronomy & Astrophysics
title: ¿Como reconocer un patrón de enfermedad infiltrativa difusa? Un reto para el radiologo.
Creators: name: Martinez Encarnacion, Lourdes
Publisher: name: Sociedad Española de Radiología Médica
Year: 2014
Subjects: subject: CT
subject: Thorax

description: Objetivo docente
Revisión del tema
Conclusiones
Bibliografía
description: Objetivo docente:
- Ayudar a identificar los diferentes patrones de las enfermedades pulmonares infiltrativas difusas (EPID),
para establecer una aproximación diagnóstica...
PHILOSOPHY OF BIOHACKING
Creators: name: Elkhova, Oxana
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 500320
subject: Psychoanalytic philosophy
classificationCode: 500312
subject: Philosophy of cognition

description: At present, the desire to overcome one's own limitations, improve one's health and condition, expand the boundaries of one's capabilities, learn to deal with one's own body and mind is more relevant than ever. For many people, belief in life after death and the possibility of immortality are unshakable sources of comfort and hope. They believe that in reality we can become the heroes of our lives, overcome our physical and mental limitations and become better than we are now. The main thing is to believe in your abilities and work on yourself every day. Other people believe that immortality is impossible and death is the natural end of the life cycle. In any case, the issues of death and immortality remain among the most important and profound problems facing humanity and their solution may require lengthy research and careful analysis. The philosophy of biohacking is to find ways to maximize the potential of the human body and brain, overcome your physical and mental limitations and, of course, extend your life through scientific and technological advances. Such techno transformation could include methods such as implanting bionic devices, improving brain activity through neuromodulation, and injecting artificial intelligence into the human mind. Biohackers are exploring various ways to optimize health and increase the productivity of the body. They use a variety of technologies, including genetic modification, changing eating habits, and physical activity.
title: Hernias abdominales: evaluación con TCMD : Conceptos básicos.
Creators: name: Lamagrande Obregón, Angélica
Publisher: name: Sociedad Española de Radiología Médica
Year: 2014
Subjects: subject: CT
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
Bibliografía
description: Objetivo docente:
Comprender los factores predisponentes,
clinica y complicaciones de las hernias abdominales. Ser capaz de reconocer las hernias en imágenes a través deejemplos representativos. Ilustrar la anatomía posquirúrgica que predispone a las hernias...
Extending the theory of propagating fluctuations: the first fully relativistic treatment and analytical Fourier-Green's functions
Creators: name: Mummery, Andrew
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The aperiodic variability ubiquitously observed from accreting black hole X-ray binary systems is generally analysed within the framework of the so-called ``theory of propagating fluctuations''. In this paper we derive the Fourier transforms of the Green's function solutions of the thin disc equations. These solutions suffice to describe all possible solutions through standard convolution techniques. Solutions are found for both Newtonian discs and general relativistic solutions with a vanishing ISCO stress. We use this new relativistic theory to highlight the Kerr black hole spin dependence of a number of observable variability properties of black hole discs. The phase lags, coherence, and power density spectra of Kerr discs are shown to be strong functions of black hole spin. Observations of the aperiodic variability of black hole accretion sources may now, at least in principle, offer a new avenue to directly constrain black hole spins.
description: 20 pages, 19 Figures. Accepted for publication in MNRAS. Code available at https://github.com/andymummeryastro/GR_prop_fluc
MUSEU.XYZ: do exercício da mediação e da curadoria descentralizada no metaverso https://museu.xyz/
Creators: name: Cunha, Ana C
Publisher: name: Labfront/UEMG
Year: 2023

description: O trabalho investiga, a partir da ideia de cocriação (URICHIO; CIZEK, 2022), o percurso de construção de uma iniciativa original e inovadora, o MUSEU.XYZ, um espaço virtual destinado à experimentação da arte, educação e cultura digital brasileira no metaverso. A partir da apresentação de como foi montado o plano estratégico, apresentamos como o grupo do museu.xyz vem balizando seus processos de desenvolvimento de obras e produtos que incluam e fortaleçam as pessoas, as comunidades e seus bens artísticos e culturais.
In silico identification and annotation of drought responsive candidate genes in Solanaceous plants
Creators: name: Mahammed Faizan
Publisher: name: figshare
Year: 2021
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Abstract: An in silico analysis was undertaken to identify drought responsive candidate genes in solanaceous plants like potato, chilli, tomato, eggplant and etc., using NCBI database. Drought tolerant plants counter the drought by producing various enzymes and transcription factors through genes associated with drought tolerance. The drought stress responsive genes were validated using Arabidopsis thaliana as reference species. The stress responsive unigenes were identified from STIFDB V.2.0 database and subjected for BLAST analysis to identify related homologous sequences from Solanum taxid using NCBI database. A total of 795 stress responsive unigenes were identified for drought stress among which 109 drought responsive unigenes were found in solanaceous taxid with sequence identities (ID) or homology of more than 80 per cent. Based on Bulk Data Retrieval (BDR) from The Arabidopsis Information Resource (TAIR), the Gene Ontology analysis for GO functional categories has revealed that, in cellular component category, genes assigned to the other intracellular components (20.37%) accounted for largest group followed by other cytoplasmic components (19.05%) and genes of chloroplast (11.77%). In biological process category, largest group of genes belong to other cellular processes (25.89%) followed by other metabolic processes (21.89%) and response to abiotic or biotic stimulus (12.44%). In Molecular functional categorization, 11.59% of genes have transferase activity; protein binding activity (10.90%); other enzymic activities (17.27 %) and other binding activities (17.95 %). The information on the drought responsive candidate genes can be used for identification and isolation of drought responsive genes for utilization in drought tolerance breeding in solanaceous crops.
Multiobjective genetic algorithms applied to heat transfer problems
Creators: name: Copiello, Diego <1980>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009
Subjects: ING-IND/10 Fisica tecnica industriale

description: In the present work, the multi-objective optimization by genetic algorithms is investigated and applied to heat transfer problems. Firstly, the work aims to compare different reproduction processes employed by genetic algorithms and two new promising processes are suggested. Secondly, in this work two heat transfer problems are studied under the multi-objective point of view. Specifically, the two cases studied are the wavy fins and the corrugated wall channel. Both these cases have already been studied by a single objective optimizer. Therefore, this work aims to extend the previous works in a more comprehensive study.
Interplay between interaction and (un)correlated disorder in one-dimensional many-particle systems: delocalization and global entanglement
Creators: name: Dukesz, Frieda
name: Zilbergerts, Marina
name: Santos, Lea F.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We consider a one-dimensional quantum many-body system and investigate how the interplay between interaction and on-site disorder affects spatial localization and quantum correlations. The hopping amplitude is kept constant. To measure localization, we use the number of principal components (NPC), which quantifies the spreading of the system eigenstates over vectors of a given basis set. Quantum correlations are determined by a global entanglement measure $Q$, which quantifies the degree of entanglement of multipartite pure states. Our studies apply analogously to a one-dimensional system of interacting spinless fermions, hard-core bosons, or yet to an XXZ Heisenberg spin-1/2 chain. Disorder is characterized by both: uncorrelated and long-range correlated random on-site energies. Dilute and half-filled chains are analyzed. In half-filled clean chains, delocalization is maximum when the particles do not interact, whereas multi-partite entanglement is largest when they do. In the presence of uncorrelated disorder, NPC and Q show a non-trivial behavior with interaction, peaking in the chaotic region. The inclusion of correlated disorder may further extend two-particle states, but the effect decreases with the number of particles and strength of their interactions. In half-filled chains with large interaction, correlated disorder may even enhance localization.
description: 13 pages, 7 figures
Envelopes of holomorphy and extension of functions of bounded type
Creators: name: Carando, Daniel
name: Muro, Santiago
Publisher: name: arXiv
Year: 2009
Subjects: subject: Functional Analysis (math.FA)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 46G20, 32D10, 46E50

description: We study the extension of holomorphic functions of bounded type defined on an open subset of a Banach space, to larger domains. For this, we first characterize the envelope of holomorphy of a Riemann domain over a Banach space, with respect to the algebra of bounded type holomorphic functions, in terms of the spectrum of the algebra. We then give a simple description of the envelopes of balanced open sets and relate the concepts of domain of holomorphy and polynomial convexity. We show that for bounded balanced sets, extensions to the envelope are always of bounded type, and that this does not necessarily hold for unbounded sets, answering a question posed by Hirschowitz in 1972. We also consider extensions to open subsets of the bidual, present some Banach-Stone type results and show some properties of the spectrum when the domain is the unit ball of $\ell_p$.
description: 25 pages
Epitaxial graphene on SiC(0001): More than just honeycombs
Creators: name: Qi, Y.
name: Rhim, S. H.
name: Sun, G. F.
name: Weinert, M.
name: Li, L.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The potential of graphene to impact the development of the next generation of electronics has renewed interest in its growth and structure. The graphitization of hexagonal SiC surfaces provides a viable alternative for the synthesis of graphene, with wafer-size epitaxial graphene on SiC(0001) now possible. Despite this recent progress, the exact nature of the graphene-SiC interface and whether the graphene even has a semiconducting gap remain controversial. Using scanning tunneling microscopy with functionalized tips and density functional theory calculations, here we show that the interface is a warped carbon sheet consisting of three-fold hexagon-pentagon-heptagon complexes periodically inserted into the honeycomb lattice. These defects relieve the strain between the graphene layer and the SiC substrate, while still retaining the three-fold coordination for each carbon atom. Moreover, these defects break the six-fold symmetry of the honeycomb, thereby naturally inducing a gap: the calculated band structure of the interface is semiconducting and there are two localized states near K below the Fermi level, explaining the photoemission and carbon core-level data. Nonlinear dispersion and a 33 meV gap are found at the Dirac point for the next layer of graphene, providing insights into the debate over the origin of the gap in epitaxial graphene on SiC(0001). These results indicate that the interface of the epitaxial graphene on SiC(0001) is more than a dead buffer layer, but actively impacts the physical and electronic properties of the subsequent graphene layers.
Graded Betti numbers of ideals with linear quotients
Creators: name: Sharifan, Leila
name: Varbaro, Matteo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics

description: In the present paper we prove that all homogeneous ideals with linear quotients are componentwise linear. Moreover we establish an extended version of Eliahou-Kervaire formula for graded Betti numbers.
description: 6 pages
Clinical and cellular characterisation of HNF1A transcription factor variants in people with young-onset diabetes
Creators: name: Cherkaoui, Ines
Publisher: name: Imperial College London
Year: 2023

description: HNF1A-MODY, is a common form of monogenic diabetes. HNF1A variants of unknown significance can be a challenge to pathogenic, and in turn may prevent a diagnosis of HNF1A-MODY. This means individuals with HNF1A-MODY who could benefit from sulfonylurea treatment, may not receive it. This thesis focuses on two HNF1A variants of unknown significance: the homozygous p.A251T (the world’s first observed homozygous potentially pathogenic variant) and heterozygous p.S19L. The overarching objective of this thesis was to assess the impact of these variants on the function of the HNF1A protein, β-cell insulin secretion, and the fundamental mechanisms driving the MODY phenotype. These investigations employed a comprehensive multimodal strategy, integrating a clinical study with in vitro functional assays utilising diverse cell lines, including immortalised and patient-derived β-cell-like cells. The clinical study underscores the difficulty in ascertaining the pathogenicity of an HNF1A variant of unknown significance exclusively through clinical characteristics and predictive biomarkers. In silico and in vitro assessments revealed that the homozygous p.A251T variant exerts a moderate impact on the HNF1A protein function, leading to a mild reduction in transactivation activity compared to wildtype HNF1A. In contrast, the heterozygous p.S19L variant exhibited a notable reduction in HNF1A protein function when compared to the wild-type, resulting in diminished transactivation activity and altered the subcellular localisation of the HNF1A protein. Due to the limitations of basic in vitro methodologies in elucidating the mechanism underlying the p.A251T variant's impact, β-cell-like cells were generated carrying the HNF1A p.A251T, derived from the probands fibroblasts obtained at skin biopsy. The A251T β-like cells displayed impaired insulin secretion in response to glucose and a decreased relative expression of insulin, as well as disrupted Ca2+ entry oscillation compared to iPSC β-cell-like cells derived from healthy donor. This study emphasises the significance of a comprehensive multimodal approach, combining clinical data, in silico analyses, and in vitro assessments, to accurately classify HNF1A variant pathogenicity.
Effect of Sun and Planet-Bound Dark Matter on Planet and Satellite Dynamics in the Solar System
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: We apply our recent results on orbital dynamics around a mass-varying central body to the phenomenon of accretion of Dark Matter-assumed not self-annihilating-on the Sun and the major bodies of the solar system due to its motion throughout the Milky Way halo. We inspect its consequences on the orbits of the planets and their satellites over timescales of the order of the age of the solar system. It turns out that a solar Dark Matter accretion rate of \approx 10^-12 yr^-1, inferred from the upper limit ΔM/M= 0.02-0.05 on the Sun's Dark Matter content, assumed somehow accumulated during last 4.5 Gyr, would have displaced the planets faraway by about 10^-2-10^1 au 4.5 Gyr ago. Another consequence is that the semimajor axis of the Earth's orbit, approximately equal to the Astronomical Unit, would undergo a secular increase of 0.02-0.05 m yr^-1, in agreement with the latest observational determinations of the Astronomical Unit secular increase of 0.07 +/- 0.02 m yr^-1 and 0.05 m yr^-1. By assuming that the Sun will continue to accrete Dark Matter in the next billions year at the same rate as in the past, the orbits of its planets will shrink by about 10^-1-10^1 au (\approx 0.2-0.5 au for the Earth), with consequences for their fate, especially of the inner planets. On the other hand, lunar and planetary ephemerides set upper bounds on the secular variation of the Sun's gravitational parameter GM which are one one order of magnitude smaller than 10^-12 yr^-1. Dark Matter accretion on planets has, instead, less relevant consequences for their satellites. Indeed, 4.5 Gyr ago their orbits would have been just 10^-2-10^1 km wider than now. (Abridged)
description: LaTex2e, 17 pages, no figures, 7 tables, 61 references. Small problem with a reference fixed. To appear in Journal of Cosmology and Astroparticle Physics (JCAP)
Origin and Nature of Radio-Loud Broad Absorption Line Quasars
Creators: name: Bruni, Gabriele <1981>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: FIS/05 Astronomia e astrofisica

description: The origin of Broad Absorption Line Quasars (BAL QSOs) is still an open issue.  Accounting for ~20% of the QSO population, these objects present broad absorption lines in their optical spectra generated from outflows with velocities up to 0.2 c. 
Nowadays, the hypotheses about their nature are principally related to orientation or evolutionary scenarios. In the first one, absorption lines are produced by outflows originated by the accretion disk, basically present in
all QSOs, but seen only when they intercept the line of sight. In the second hypothesis, BAL QSOs would be young or recently re-fueled QSOs, still ejecting their dust cocoon. In this case orientation would not play a role, since the absorption features would be produced by spherically ejected matter.
In this work we present the results of a multi-frequency study of a
Radio-Loud BAL QSO sample, and a comparison sample of Radio-Loud non-BAL QSOs. We performed observations from radio to Near-Infrared, aiming at collecting useful informations about the orientation, the age, and the morphologies of these objects. Various techniques have been applied, including local and continental radio interferometry, single dish observations and spectroscopy.
The comparison with the non-BAL QSO sample allows us to  
conclude that no particular orientation is present in BAL QSOs.
Moreover, various morphologies and ages can be found, analogously to "normal" QSOs. Thus, the solution to this astrophysical problem seems not to reside in a peculiarity of the BAL QSO subclass with respect to non-BAL QSOs, since both the studied models do not completely explain the observed characteristics.
Further experiments with future instrumentation will allow us to underline useful differences and test the physical conditions in BAL QSOs.
Upper critical field, lower critical field and critical current density of FeTe0.60Se0.40 single crystal
Creators: name: Yadav, C S
name: Paulose, P L
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The transport and magnetic studies are performed on high quality FeTe0.60Se0.40 single crystals to determine the upper critical fields (Hc2), lower critical field (Hc1) and the Critical current density (Jc). The value of upper critical field Hc2 are very large, whereas the activation energy as determined from the slope of the Arrhenius plots are was found to be lower than that in the FeAs122 superconductor. The lower critical field was determined in ab direction and c direction of the crystal, and was found to have a anisotropy of 'gamma'{=(Hc1//c) / (Hc1//b)} ~ 4. The magnetic isotherms measured up to 12 Tesla shows the presence of fishtail behavior. The critical current densities at 1.8K of the single crystal was found to almost same in both ab and c direction as 1X105 Amp/cm2 in low field regime.
description: 9 pages, 6 figures
Order-invariant measures on causal sets
Creators: name: Brightwell, Graham
name: Luczak, Malwina
Publisher: name: arXiv
Year: 2009
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: A causal set is a partially ordered set on a countably infinite ground-set such that each element is above finitely many others. A natural extension of a causal set is an enumeration of its elements which respects the order. We bring together two different classes of random processes. In one class, we are given a fixed causal set, and we consider random natural extensions of this causal set: we think of the random enumeration as being generated one point at a time. In the other class of processes, we generate a random causal set, working from the bottom up, adding one new maximal element at each stage. Processes of both types can exhibit a property called order-invariance: if we stop the process after some fixed number of steps, then, conditioned on the structure of the causal set, every possible order of generation of its elements is equally likely. We develop a framework for the study of order-invariance which includes both types of example: order-invariance is then a property of probability measures on a certain space. Our main result is a description of the extremal order-invariant measures.
description: Published in at http://dx.doi.org/10.1214/10-AAP736 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
A Participatory Design Method for Qualitative Data Sonification
Creators: name: Young, Emma
Publisher: name: Lancaster University
Year: 2021
Subjects: audio
sonification
participatory design
Human computer interaction
sound art
sound sketching
interaction design
foley
design thinking
human-centred design

description: Sound is an emotional driver that can stimulate and shape our responses to create highly engaging and immersive experiences. As such, sound design plays a major role in media and games, yet often remains an afterthought in the design of interactive systems. Sound ideas are difficult to communicate without familiarity with audio terminology, consequently, sound design briefs are often poorly described. While sketching and quick and dirty prototyping is widely practiced in visual design, there is a lack of comparable tools for communicating and exchanging ideas about sound, leading to time-consuming design and re-design processes. Research in the Sonic Interaction Design and Data Sonification fields has led to the development of sound design toolkits enabling faster experimentation with sound, however these proprietary tools offer digital interfaces which are restrictive and unintuitive for the novice user. There are calls in these communities for accessible methods for designing through physical sound making, with studies exploring the use of vocalisation and Foley-based techniques to mitigate against the inherent technical biases associated with existing solutions. Using a Research through Design approach, this thesis explores Foley-based sketching and establishes that designing through sound making can benefit participatory design processes; support knowledge exchange; and inspire new and divergent ideas. By putting sounding materials directly in the hands of individuals, this work examines the concept of qualitative data sonification through embodied kinaesthetic action, which can produce meaningful sonic representations of experiential phenomena. The trialling of accessible group-based activities to support this rapid experimentation with sound led to the formulation and development of a new method, ‘Embosonic Design’. The method was trialled in two major design projects, ‘Her[sonifications]’, where it was employed as an arts-based approach in the participatory design of an interactive sound installation; and ‘Emotional Machines’, where it formed a major part of a mixed modal interaction study in an industry-based innovation context, facilitating ideation and interaction design for future smart speakers at BBC Research and Development. The conceptual frameworks, practical tools and guiding philosophies contained in this thesis will help researchers and designers employ the thinking and methods in their design-led innovation work and participatory design practice.
On fundamental groups of quotient spaces
Creators: name: Calcut, Jack S.
name: Gompf, Robert E.
name: McCarthy, John D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Topology (math.GN)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 54B15, 57M05, 37C10, 55U10

description: In classical covering space theory, a covering map induces an injection of fundamental groups. This paper reveals a dual property for certain quotient maps having connected fibers, with applications to orbit spaces of vector fields and leaf spaces in general.
description: 12 pages, 4 figures; added references, keywords, and Remark 1.2; accepted at Topology and its Applications
Maximum likelihood identification of linear discrete-time systems
Creators: name: De Glas, Michel
Publisher: name: University of British Columbia
Year: 2010

description: The theoretical properties of the Maximum Likelihood estimator, for both single input-single output and multivariable systems, are considered. New results relative to convergence properties of some identification methods of single input-single output systems are obtained. A unified approach to the Maximum Likelihood identification method of multivariable systems is proposed. Numerical tests on a computer are performed.
Ricerca di marcatori molecolari nella prevenzione dei tumori di testa e collo
Molecular Markers in Head and Neck Cancer Prevention
Creators: name: Girardi, Ambra <1980>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: BIO/17 Istologia

description: Oral cavity cancers (OSCC) are among the most malignances worldwide. OSCC tipically affects men in their IV or V dedade of life, and the most relevant risk factors are tobacco and alcohol consumption. OSCCs generally exhibit poor prognosis, and late stage identification correlates with higher mortality rates. Basic prognostic factors, are tumor size and presence of lymph node and/or distance metastases (T classification, N, M). However, tumors with the same TNM grade and similar morphology may have completely different evolution, because of their intrinsic biological characteristics. For these reasons, the identification of new molecular markers with a predictive value, could represent useful tools in OSCC prevention, prognosis and treatment.
In the first part of my PhD project I evaluated the loss of heterozygosity as a possible cause of deregulation of well-known tumor suppressors genes. Obtained data put on light the importance of this rearrangement and genes PDCD4, CTNB1, CASP4 and HSP23, in the onset and progression of OSCC.
Subsequently, the analysis of the expression profile of miRNAs, led to the identification of some miRNAs that seems to be involved in cancer development and metastatic progression. In both cases, we need further investigations to understand whether these molecules may be used ideal markers in OSCC diagnosis and treatment.
Environment-induced entanglement with a single photon
Creators: name: Hor-Meyll, Malena
name: Auyuanet, Adriana
name: Borges, Carolina
name: Aragão, Adriano
name: Huguenin, José Augusto
name: Khoury, Antonio
name: Davidovich, Luiz
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose an all-optical setup, which couples different degrees of freedom of a single photon, to investigate entanglement generation by a common environment. The two qubits are represented by the photon polarization and Hermite-Gauss transverse modes, while the environment corresponds to the photon path. For an initially two-qubit separable state, the increase of entanglement is analyzed, as the probability of an environment-induced transition ranges from zero to one. An entanglement witness that is invariant throughout the evolution of the system yields a direct measurement of the concurrence of the two-qubit state.
description: 11 pages, 3 figures
FOPPA: An Open Database of French Public Procurement Award Notices From 2010--2020
Creators: name: Potin, Lucas
name: Labatut, Vincent
name: Morand, Pierre-Henri
name: Largeron, Christine
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Public Procurement refers to governments' purchasing activities of goods, services, and construction of public works. In the European Union (EU), it is an essential sector, corresponding to 15% of the GDP. EU public procurement generates large amounts of data, because award notices related to contracts exceeding a predefined threshold must be published on the TED (EU's official journal). Under the framework of the DeCoMaP project, which aims at leveraging such data in order to predict fraud in public procurement, we constitute the FOPPA (French Open Public Procurement Award notices) database. It contains the description of 1,380,965 lots obtained from the TED, covering the 2010--2020 period for France. We detect a number of substantial issues in these data, and propose a set of automated and semi-automated methods to solve them and produce a usable database. It can be leveraged to study public procurement in an academic setting, but also to facilitate the monitoring of public policies, and to improve the quality of the data offered to buyers and suppliers.
title: GSICS quarterly. Volume 3, number 2 (2009)
Creators: name: Global Space-Based Inter-Calibration System Coordination Center,
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Environmental Satellite, Data, and Information Service, Center for Satellite Applications and Research
Year: 2009
Subjects: subject: Satellite meteorology
subject: Global Observing System (Meteorology)

description: GSICS Quarterly is a newsletter designed to communicate GSICS activities to all GSICS members and partners, as well as to satellite data users and policy makers
title: GSICS quarterly. Volume 2, number 2 (2008)
Creators: name: Global Space-Based Inter-Calibration System Coordination Center,
Publisher: name: U.S. Department of Commerce, National Oceanic and Atmospheric Administration, National Environmental Satellite, Data, and Information Service, Center for Satellite Applications and Research
Year: 2008
Subjects: subject: Satellite meteorology
subject: Global Observing System (Meteorology)

description: GSICS Quarterly is a newsletter designed to communicate GSICS activities to all GSICS members and partners, as well as to satellite data users and policy makers