cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular insight into amyloid oligomer destabilizing mechanism of flavonoid derivative 2-(4′ benzyloxyphenyl)-3-hydroxy-chromen-4-one through docking and molecular dynamics simulations
Creators: name: Akhil Kumar
name: Srivastava, Swati
name: Shubhandra Tripathi
name: Singh, Sandeep Kumar
name: Saripella Srikrishna
name: Sharma, Ashok
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Information and Computing Sciences
Biological Sciences
Chemistry
Physics
Biochemistry
Biophysics

description: Aggregation of amyloid peptide (Aβ) has been shown to be directly related to progression of Alzheimer’s disease (AD). Aβ are neurotoxic and their deposition and aggregation ultimately lead to cell death. In our previous work, we reported flavonoid derivative (compound 1) showing promising result in transgenic AD model of Drosophila. Compound 1 showed prevention of Aβ induced neurotoxicity and neuroprotective efficacy in Drosophila system. However, mechanism of action of compound 1 and its effect on the amyloid is not known. We therefore performed molecular docking and atomistic, explicit-solvent molecular dynamics simulations to investigate the process of Aβ interaction, inhibition and destabilizing mechanism. Results showed different preferred binding sites of compound 1 and good affinity towards the target. Through the course of 35 ns molecular dynamics simulation, conformations_5 of compound 1 intercalates into the hydrophobic core near the salt bridge and showed major structural changes as compared to other conformations. Compound 1 showed interference with the salt bridge and thus reducing the inter strand hydrogen bound network. This minimizes the side chain interaction between the chains A-B leading to disorder in oligomer. Contact map analysis of amino acid residues between chains A- B also showed lesser interaction with adjacent amino acids in the presence of compound 1 (conformations_5). The study provides an insight into how compound 1 interferes and disorders the Aβ peptide. These findings will further help to design better inhibitors for aggregation of the amyloid oligomer.
DISAGGREGATED ACCRUALS AND PREDICTION OF FUTURE CASH FLOWS: AN EFFECT OF GLOBAL FINANCIAL CRISIS 2008-09
Creators: name: Rai Imtiaz Hussain, Noor Saadah
Publisher: name: TuEngr Group
Year: 2020
Subjects: World Financial Crisis
Imminent Cash Flows
Accrual Components
Pakistan Stock Exchange
Disaggregated accruals
Free cash flow (FCF)
Trading assets (TA), Financial asset (FA)
Financial liabilities (FL)
Trading liabilities (TL)
Post financial crisis
Non-trading liabilities (NTL)
Non-trading assets (NTA).

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 5, 11A05R: 1-11
Wie verändert die Cloud den Betrieb von ICT-Infrastrukturen?
Creators: name: Liebhart, Daniel
Publisher: name: Netzmedien
Year: 2010
Subjects: IT-Management
ITIL
Cloud
004: Informatik

description: Bis Cloud Computing, als Variante der Bereitstellung von Anwendungsfunktionalität und Rechenleistung, als ernsthafte Alternative zu gängigen IT-Leistungen in Betracht kommen kann, sind organisatorische und technische Rahmenbedingungen zu schaffen.
Degradation of ciprofloxacin in water by advanced oxidation process: kinetics study, influencing parameters and degradation pathways
Creators: name: Sayed, Murtaza
name: M. Ismail
name: Sanaullah Khan
name: Tabassum, Safia
name: Khan, Hasan M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry

description: Gamma-radiation-induced degradation of ciprofloxacin (CIP) in aqueous solution and the factors affecting the degradation process have been investigated. The results showed that CIP (4.6 mg/L) was almost completely degraded at an absorbed dose of 870 Gy. The kinetic studies of aqueous solutions containing 4.6, 10, 15 and 17.9 mg/L indicated that the decomposition of CIP by gamma irradiation followed pseudo-first-order kinetics and the decay constant (k) decreased from 5.9 × 10−3 to 1.6 × 10−3 Gy−1 with an increase in CIP initial concentration from 4.6 to 17.9 mg/L. The effect of saturation of CIP solution with N2, N2O or air on radiation-induced degradation of CIP was also investigated. The effects of radical scavengers, such as t-BuOH and i-PrOH, showed the role of reactive radicals towards degradation of CIP in the order of . The apparent second-order rate constant of with CIP was calculated to be 2.64 × 109 M−1 s−1. The effects of solution pH as well as natural water contaminants, such as , , and , on CIP degradation by gamma-irradiation were also investigated. Major degradation products, including organic acids, were identified using UPLC-MS/MS and IC, and degradation pathways have been proposed.
The European Commission's ability to deal with wicked problems: an in-depth case study of the governance of food security
Creators: name: Candel, Jeroen J.L.
name: Breeman, Gerard E.
name: Termeer, Catrien J.A.M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: The European Commission's ability to cope with wicked problems is generally viewed as inadequate because of its hierarchical and inflexible modus operandi. Recent research suggests, however, that the Commission may be better equipped to deal with wicked problems than is commonly assumed. To elucidate these contradictory viewpoints, we analysed conditions that enable or constrain the Commission in dealing with wicked problems. To do so, we applied a framework consisting of five governance capabilities required to deal with wicked problems (reflexivity, responsiveness, resilience, revitalization and rescaling) to a case study of how the Commission deals with the wicked problem of food security. Although our results confirm some of the earlier critiques, we have also identified various enabling conditions, most notably inter-service and inter-institutional procedures and structures, boundary arrangements and a widespread tolerance of frame conflicts, uncertainty and cross-scale dynamics. However, the Commission lacks a mechanism to continuously monitor and adjust its capabilities, thereby running the risk of challenges remaining unforeseen and unanticipated.
Syspasis carinator
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Syspasis
Syspasis carinator

description: Syspasis carinator (FABRICIUS, 1798)
M a t e r i a l e x a m i n e d: Trap 7: 2♀♀ 23.iv.-5.v., 1♀ 5-20.v.
D i s t r i b u t i o n: Transpalaearctic, known from Georgia (RIEDEL et al. 2018).
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 106, DOI: 10.5281/zenodo.10788481
ELASTICITY MEASUREMENT OF FOOD DEMAND IN PAKISTAN: CROSS-PRICE AND OWN PRICE ELASTICITY ANALYSIS
Creators: name: Kausar Naheed, Ijaz Hussain
Publisher: name: TuEngr Group
Year: 2020
Subjects: Food Demand
Elasticity Measurement
Marshallian elasticity
Food price elasticity
Cross-price elasticity
Elasticity of food demand items.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 5, 11A05S: 1-6
Degradation of Ciprofloxacin in water by Advanced Oxidation Process: Kinetics Study, Influencing Parameters and Degradation Pathways
Creators: name: Sayed, Murtaza
name: M. Ismail
name: Sanaullah Khan
name: Tabassum, Safia
name: Khan, Hasan M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Physics
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Engineering
subject: Biophysics

description: ABSTRACTGamma radiation-induced degradation of ciprofloxacin (CIP) in aqueous solution and the factors affecting the degradation process have been investigated. The results showed that CIP (4.6 mg/L) was almost completely degraded at an absorbed dose of 870 Gy. The kinetic studies of aqueous solutions containing 4.6, 10, 15 and 17.9 mg/L indicated that the decomposition of CIP by gamma-irradiation followed pseudo-first order kinetics and the decay constant (k) decreased from 5.9×10-3 Gy-1 to 1.6×10-3 Gy-1 with an increase in CIP initial concentration from 4.6 to 17.9 mg/L. The effect of saturation of CIP solution with N2, N2O or air on radiation-induced degradation of CIP was also investigated. The effects of radical scavengers, like t-BuOH and i-PrOH showed the role of reactive radicals towards degradation of CIP in the order of •OH > eaq‒ > •H. The apparent second order rate constant of •OH with CIP was calculated to be 2.64 × 109 M-1s-1. The effects of solution pH as well as natural water contaminants, like HCO3‒, CO3‒, NO3‒, and NO2‒ on CIP degradation by gamma - irradiation was also investigated. Major degradation products, including organic acids were identified using UPLC-MS/MS and IC and degradation pathways have been proposed.
Syspasis haesitator
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Syspasis
Syspasis haesitator

description: Syspasis haesitator (W ESMAEL, 1845)
M a t e r i a l e x a m i n e d: Trap 2: 1♀ 5-20.v., 2♀♀ 1-15.vi.; trap 4: 2♀♀ 1-15.vi., 1♀ 29.vi.- 13.vii.; trap 12: 2♀♀ 10-24.viii.
D i s t r i b u t i o n: Transpalaearctic, new record for Georgia and the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 106, DOI: 10.5281/zenodo.10788481
Towards a pre-teen typology of digital media
Creators: name: Grimley, Michael
name: Allan, Mary
Publisher: name: Swinburne
Year: 2024

description: Whilst prior research has identified children as avid users of new technologies, insufficient studies have explored their patterns of use. This paper investigates how New Zealand pre-teens use technology out of school and identifies a typology of technology use. Two hundred and twenty four children between 10 and 12 years of age completed a comprehensive questionnaire about their use of technology. Results indicated that children of this age were immersed in technology related activities. A principal components factor analysis revealed a typology with five distinct factors underlying pre-teen digital behaviour. Two factors showed some differentiation by gender but differences were not evident for socio-economic factors.
Molecular dynamics simulation studies of GSK-3β ATP competitive inhibitors: understanding the factors contributing to selectivity
Creators: name: Minhajul Arfeen
name: Patel, Rahul
name: Tosif Khan
name: Bharatam, Prasad V.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Pharmacology
subject: Biochemistry

description: Glycogen synthase kinase-3 is a constitutively acting, multifunctional serine threonine kinase, the role of which has been implicated in several physiological pathways and has emerged as a promising target for the treatment of type-II diabetes and Alzheimer’s disease. In order to provide a detailed understanding of the origin of selectivity determinants of ATP competitive inhibitors, molecular dynamics simulations in combination with MM-PBSA binding energy calculations were performed using crystal structures of GSK-3β and CDK-2 in complex with 12 ATP competitive inhibitors. Analysis of energy contributions indicate that electrostatic interaction energy dictates the selectivity of ATP competitive inhibitors against CDK-2. Key interactions as well as residues that potentially make a major contribution to the binding free energy were identified at the ATP binding site. This analysis stresses the need for the inhibitors to interact with Lys85, Thr138, and Arg141 in the binding site of GSK-3β to show selectivity. The residue-wise energy decomposition analysis further suggested the additional role of Gln185 in determining the selectivity of maleimides. The results obtained in this study can be utilized to design new selective GSK-3 ATP competitive inhibitors.
Between-person causal relationships between self and social relevance and sharing intentions during exposure to social media messages about voting
Creators: name: Cosme, Danielle
name: Chan, Hang Yee
name: Scholz, Christin
name: Falk, Emily
name: Tartak, Jose
name: Cooper, Nicole
name: Martin, Rebecca
name: Resnick, Anthony
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Communication
subject: Psychology
subject: FOS: Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: experiment
subject: message framing intervention
subject: self-relevance
subject: sharing
subject: social media
subject: social relevance
subject: voting

description: Behavioral and neuroimaging evidence suggests that self and social relevance are two important factors that motivate sharing (Baek et al., 2017; Cosme et al., 2022) and information virality (Scholz et al., 2017). Across six online studies, one previous study showed that the more that people perceive messages to be self and socially relevant, the more motivated they are to share them (Cosme et al., 2022). These correlational relationships were robust across various message mediums (social media posts, newspaper headlines), content types (COVID-19, general health, voting, climate change), and sharing audiences (social media, direct sharing with another person). The authors also assessed causal relationships between relevance and sharing, and found that manipulating self and social relevance through a message framing experiment causally increased intentions to share news abstracts about climate change and health. The present work builds directly on this causal study and aims to replicate the results using social media messages about voting rather than news abstracts about climate change and health using a between-person (rather than within-person) design.
Where has all the physical education gone? results of a generalist primary schools teachers' survey on teaching physical education
Creators: name: Cowley, Vicki
name: Hamlin, Michael J.
name: Grimley, Michael
Publisher: name: Swinburne
Year: 2024

description: Concerns about low levels of children's physical activity and motor skill development, prompted the Ministry of Education to trial a physical activity pilot project (PAPP) in 16 New Zealand primary schools. The project comprised professional development and training in physical education for lead teachers and introduced four physical activity coordinators to liaise with and increase physical activity opportunities in the pilot schools. A survey of generalist teachers (128 baseline, 155 post-intervention) from these schools looked at timetabled physical activity sessions and issues related to teaching physical education. The authors calculated means and standard deviations of data relating to timetabled PE sessions and used a one-way analysis of variance to determine significant differences. Results indicated time devoted to physical activity related subjects significantly increased over the course of the intervention. Teacher's reported improved confidence and competence, which resulted in an improvement in quality physical education delivered more often.
Investigation of flap flexibility of β-secretase using molecular dynamic simulations
Creators: name: Hezekiel M. Kumalo
name: Soumendranath Bhakat
name: Soliman, Mahmoud E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Flap motif and its dynamics were extensively reported in aspartate proteases, e.g. HIV proteases and plasmepsins. Herein, we report the first account of flap dynamics amongst different conformations of β-secretase using molecular dynamics simulation. Various parameters were proposed and a selected few were picked which could appropriately describe the flap motion. Three systems were studied, namely Free (BACEFree) and two ligand-bound conformations, which belonged to space groups P6122 (BACEBound1) and C2221 (BACEBound2), respectively and four parameters (distance between the flaps tip residue, Thr72 and Ser325, d1; dihedral angle, ϕ (Thr72-Asp32-Asp228-Ser325); TriCα angles, θ1 (Thr72-Asp32-Ser325), and θ2 (Thr72-Asp228-Ser325)) were proposed to understand the change in dynamics of flap domain and the extent of flap opening and closing. Analysis of, θ2, d1, θ1 and ϕ confirmed that the BACEFree adopted semi-open, open and closed conformations with slight twisting during flap opening. However, BACEBound1 (P6122) showed an adaptation to open conformation due to lack of hydrogen bond interaction between the ligand and flap tip residue. A slight flap twisting, ϕ (lateral twisting) was observed for BACEBound1 during flap opening which correlates with the opening of BACEFree. Contradictory to the BACEBound1, the BACEBound2 locked the flap in a closed conformation throughout the simulation due to formation of a stable hydrogen bond interaction between the flap tip residue and ligand. Analyses of all three systems highlight that d1, θ2 and ϕ can be precisely used to describe the extent of flap opening and closing concurrently with snapshots along the molecular dynamics trajectory across several conformations of β-secretase.
Reengineering cloud data centers
Creators: name: Spillner, Josef
name: Sill, Alan
Publisher: name: IEEE
Year: 2018
Subjects: Cloud computing
005: Computerprogrammierung, Programme und Daten

description: Data centers should be among the most automated, robust environments on the planet. Instead, they often remain stuck in the past as agglomerations of outdated technologies. It is time to take this problem seriously and directly address the needs of data centers for modern automation and control through analytics-driven methods.
Nachhaltigkeit in der Informatik bei SWICA
Creators: name: Gabi, Lukas
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2022
Subjects: Nachhaltigkeit
Informatik
Sustainability
IT
004: Informatik

description: Die Treibhausgasemissionen der Informatik steigen trotz zunehmender Effizienz der Systeme mit der Digitalisierung laufend an und werden global auf 2 bis 3 % aller Emissionen geschätzt. Nicht zuletzt deswegen rückt die Nachhaltigkeit auch in der Informatik verstärkt in den Fokus. Die SWICA hat bereits eine unternehmensweite Nachhaltigkeitsstrategie entwickelt, diese soll nun für die IT-Abteilung konkretisiert werden. Ziel dieser Arbeit ist es, die theoretischen Grundlagen zur Messung der Nachhaltigkeit im Unternehmen zu erarbeiten sowie für die IT-Abteilung der SWICA konkrete Handlungsvorschläge für die nachhaltige Entwicklung abzuleiten. Aus der aktuellen Literatur erschliesst sich, dass die Methoden zur Messung von Emissionen in der Informatik aufgrund mangelnder Angaben der Hersteller sehr ungenau sind und nur für grobe Abschätzungen verwendet werden. Aufbauend auf bereits firmenintern erhobenen Daten sowie Interviews mit Schlüsselpersonen wurde mit einem ganzheitlichen Ansatz die Nachhaltigkeit der IT-Abteilung eingeschätzt. Zudem konnte ihre aktuelle Situation anhand eines etablierten Frameworks qualitativ beurteilt werden. Als eine zentrale Massnahme empfiehlt der Autor die Entwicklung einer mit dem Business abgestimmten IT-Nachhaltigkeitsstrategie mit konkreten Zielen und Verantwortlichkeiten. Dabei sollte der Fokus nicht rein auf den direkt durch die IT verursachten Emissionen, sondern auch auf den durch die IT ermöglichten Emissionseinsparungen liegen, da dort aktuell ein viel grösseres Einsparpotenzial existiert.
Comparing computer game and traditional lecture using experience ratings from high and low achieving students
Creators: name: Grimley, Michael
name: Green, Richard
name: Nilsen, Trond
name: Thompson, David
Publisher: name: Swinburne
Year: 2024

description: Computer games are purported to be effective instructional tools that enhance motivation and improve engagement. The aim of this study was to investigate how tertiary student experiences change when instruction was computer game based compared to lecture based, and whether experiences differed between high and low achieving students. Participants consisted two cohorts enrolled in a first year university course (Cohort 1, traditional: male=42, female=17; Cohort 2, computer game: male=42, female=7). Cohort 1 experienced course content as traditional lectures, Cohort 2 experienced course content embedded within a computer game. Csikszentmihalyi's experience sampling method was used to sample experiences of students for each cohort during instruction. Results showed that the computer game group were more challenged and valued the activity more than the traditional group, but were inclined to wish they were doing something else. High achieving students during game mode showed greater concentration but found it harder to concentrate and found game mode more sociable and lecture mode more boring. High achievers perceived greater success for lecture mode and found lectures more satisfying. Individual profiles of high and low achieving students for each mode indicated that games afforded better experiences for low achieving students but poorer experiences for high achieving students.
Within-person causal relationships between self and social relevance and sharing intentions during exposure to social media messages about voting
Creators: name: Cosme, Danielle
name: Chan, Hang Yee
name: Scholz, Christin
name: Martin, Rebecca
name: Tartak, Jose
name: Cooper, Nicole
name: Falk, Emily
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Communication
subject: Psychology
subject: FOS: Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: experiment
subject: message framing intervention
subject: self-relevance
subject: sharing
subject: social media
subject: social relevance
subject: voting

description: Behavioral and neuroimaging evidence suggests that self and social relevance are two important factors that motivate sharing (Baek et al., 2017; Cosme et al., 2022) and information virality (Scholz et al., 2017). Across six online studies, one previous study showed that the more that people perceive messages to be self and socially relevant, the more motivated they are to share them (Cosme et al., 2022). These correlational relationships were robust across various message mediums (social media posts, newspaper headlines), content types (COVID-19, general health, voting, climate change), and sharing audiences (social media, direct sharing with another person). The authors also assessed causal relationships between relevance and sharing, and found that manipulating self and social relevance through a message framing experiment causally increased intentions to share news abstracts about climate change and health. The present work builds directly on this causal study and aims to replicate the results using social media messages about voting rather than news abstracts about climate change and health.
Reactions of some grape cultivars to Dematophora necatrix
Creators: name: Mansoori, B.
name: Dorostkar, M.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: White root rot of grape caused by Dematophora necatrix is prevalent in Jahrom and Mimand of Fars province, Iran. In a greenhouse tests 30 gr of colonized wheat kernels per 1,200 g soil amended with peat moss were used to inoculate rooted cuttings of 29 Vitis vinifera and one hybrid cultivar in the pots. After 150 days most cuttings belonging to 27 V. vinifera cultivars and the hybrid died and were evaluated susceptible. However, 9 seedlings from 'Bidaneh Sephid Gazvin' and 3 from 'Bidaneh Ghermez Gazvin' remained alive. Roots of these cuttings were totally free from mycelium and looked healthy. The seedlings were transplanted after root disinfection with benomyl, in soil near Zarghan Vineyard Collection for further studies.
description: VITIS - Journal of Grapevine Research, Vol. 47 No. 4 (2008): Vitis
IoMiRCA : root cause analysis in IoT-extended 5G microservice environments
Creators: name: Heeb, Zeno
name: Kalinagac, Onur
name: Soussi, Wissem
name: Gür, Gürkan
Publisher: name: Association for Computing Machinery
Year: 2023
Subjects: Root cause analysis
IoT
Microservice
Performance monitoring
Anomaly detection
004: Informatik

description: Softwarized services in converged networks are evolving from monolithic applications to distributed architectures, often comprising numerous microservices. At the same time, with the massive proliferation of IoT devices, much more complexity and diversity are added to such critical infrastructures. In that regard, Root Cause Analysis (RCA) is an important part of a running distributed service ecosystem to keep the applications available and manageable by finding the root causes of errors and malfunctions. This paper provides a topology graph-based anomaly detection and RCA solution for the microservice architecture in edge-to-cloud environments entailing microservices in combination with IoT.
title: The social environment and psychosis: search for symptom specificity
Creators: name: Wickham, Sophie
Publisher: name: University of Liverpool Repository
Year: 2015

description: Research with clinical and nonclinical samples has linked multiple psycho-social risk factors with psychosis. There has since been an emphasis on the importance of investigating specific symptoms experienced within the psychosis spectrum to better understand the psychological processes involved. The studies included in this doctoral thesis used cross sectional methods to explore relationships between specific social adversities and specific symptoms within the psychotic domain and also depression, using a number of different samples (students, client groups and general population). This thesis also explores mediating mechanisms between adversities and specific symptoms, paying particular attention to the role of specific adversities in paranoid ideation. I found that perceived childhood inequality, neglect and adulthood social deprivation and insecure attachment styles predicted paranoid thoughts in student, epidemiological and clinical samples. In my student study I further developed and validated a tool to measure perceived relative deprivation. I then used this tool and found that personal perceptions of injustice and low social rank mediated the relationship between perceived relative deprivation and paranoia. In my epidemiological study I found that experiences of discrimination, lack of trust and stress partially explained the relationship between current social disadvantage and paranoia. In my two clinical studies I found that negative self-esteem explained the association between insecure attachment dimensions and paranoia, and strong perceptions of injustice and an over perception of justice in the world explained the association between childhood emotional neglect and paranoia. Considering hallucinations, I found specific associations between perceived childhood deprivation and hallucinations in my student sample and between sexual abuse and hallucinations in my patient sample, although none of the mediating variables tested in this thesis accounted for these associations, suggesting other mechanisms may be important. The findings of the current studies suggest that it is possible to identify specific associations between adversity and psychotic symptoms in general, and highlight the need to develop a science of public mental health, which at present barely exists as a discipline. In the future, more complex and imaginative designs examining specific environments, specific outcomes, and specific mediating mechanisms will be required if this is to be achieved.
Optimisation and comparison of transient expression methods to express the green fluorescent protein in the obligate biotrophic oomycete Plasmopara viticola
Creators: name: Dubresson, R.
name: Kravchuk, Z.
name: Neuhaus, J. M.
name: Mauch-Mani, B.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: Grape downy mildew is caused by Plasmopara viticola, an obligate biotrophic oomycete and a major pathogen of grapevine. Studying obligate biotrophic pathogens is difficult as they cannot grow without their host. We therefore attempted to develop a method where the pathogen could be visualized and quantified in planta without killing the host plant. To this end P. viticola was transformed with the marker gene gfp coding for the green fluorescent protein. Various transformation methods, namely electroporation, particle bombardment and transformation with Agrobacterium tumefaciens were applied. Although some methods yielded positive transformation events, no stable strain of P. viticola expressing gfp could be generated. Using the electroporation method, we obtained transient P. viticola transformants expressing gfp over 4 generations. In contrast, particle bombardment failed in transforming P. viticola. Transformation with A. tumefaciens had a low efficiency, only some structures were fluorescent and fluorescence was never observed in the subsequent generations.
description: VITIS - Journal of Grapevine Research, Vol. 47 No. 4 (2008): Vitis
title: Investigation into mycobacterial persistence and early markers of outcome in the treatment of pulmonary tuberculosis
Creators: name: Sloan, Derek
Publisher: name: University of Liverpool Repository
Year: 2014

description: Background: Development of ultra-short chemotherapy for tuberculosis (TB) is thwarted by drug-tolerant bacillary persistence and a lack of surrogate endpoints to predict outcome from early clinical studies. Characterising bacillary elimination amongst TB patients may provide important new information. Bacilli harbouring intra-cytoplasmic lipid bodies (LBs) may represent a drug-tolerant phenotype, responsible for delayed bacterial clearance. Methods: Malawian adults with pulmonary TB were treated with standard 6 month therapy. Two quantitative sputum culture methods were used to model bacillary elimination during the first 2 months; serial sputum colony counting (SSCC) and time to positivity (TTP) in BACTEC MGIT broth. Fluorescence microscopy was used to assess the proportion of LB positive bacilli on sputum smears. Plasma concentrations of anti-TB drugs were assayed at day 14 or 21. Patients were followed until one year post-treatment. Outcomes were defined as favourable (stable cure) or unfavourable (failure/relapse). The effect of microbiological and pharmacological factors on outcome was assessed. Results: 169 patients (59% with HIV co-infection) were recruited. Of 133 final outcomes, 15 (11%) were unfavourable. Partial likelihood non-linear mixed effects (NLME) modelling of SSCC data from 86 (64%) patients showed biphasic bacillary elimination; slow late-phase eradication of persisters was associated with unfavourable outcome (p=0.001). Linear mixed effects (LME) modelling of TTP data from 124 (93%) patients showed that a slower MGIT Bacillary Elimination Rate (MBER) was associated with unfavourable outcome (p=0.007). 28% (range 0-79%) of acid-fast bacilli in baseline sputum samples were LB positive. During the first month there was a trend towards higher LB counts in patients who went on to have unfavourable vs. favourable outcomes (p=0.085). Low plasma rifampicin and isoniazid concentrations were reported in 87% and 50% patients respectively. A lower isoniazid AUC(0-6hr) exposure was associated with unfavourable outcome (p=0.035). Conclusions: The two main findings were: 1. Modelling of bacillary elimination during the first 2 months of TB therapy predicted long-term outcome. The MBER, in particular, could be calculated for 93% of patients and should be considered as a surrogate marker for early clinical trials. 2. The observation of a higher proportion of LB positive bacilli in later sputum samples from patients with unfavourable outcomes suggests that these may be drug-tolerant persister cells, with negative implications for treatment efficacy.
Syspasis optica
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Syspasis
Syspasis optica

description: Syspasis optica (GRAVENHORST, 1829)
M a t e r i a l e x a m i n e d: Trap15: 1♀ 2-16.vi.
D i s t r i b u t i o n: Western Palaearctic, known from the Caucasus region (RIEDEL 2021), new for Georgia.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 106, DOI: 10.5281/zenodo.10788481
Free and glycoconjugated volatiles of V. vinifera grape 'Falanghina'
Creators: name: Lamorte, S. A.
name: Gambuti, A.
name: Genovese, A.
name: Selicato, S.
name: Moto, L.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: The potential aroma of Vitis vinifera Falanghina was investigated by means of qualitative and semiquantitative determinations of volatile free and glycosidically bound secondary metabolites. Glycosilated geranic acid, α-terpineol, eugenol and 2-exo-hydroxy-1,8-cineole play a central role in characterizing the potential aromatic expression of this cultivar. In particular glycosilated 2-exo-hydroxy-1,8-cineole found in Falanghina must may be discriminant and hypothetically contributes to identify Falanghina wine origin and affiliation because of its high chemical and biological stability.
description: VITIS - Journal of Grapevine Research, Vol. 47 No. 4 (2008): Vitis
Webinar summary : the metaverse : a role to play in mental healthcare?
Creators: name: Pierrès, Oriane
Publisher: name: European Association of Centres of Medical Ethics
Year: 2023
Subjects: Digital Health
Healthcare
006: Spezielle Computerverfahren
613: Persönliche Gesundheit

description: Webinar summary on the role of the metaverse in mental healthcare. The summary addresses the potential and risk of digital tools for mental healthcare support as well as discussed the need for a right to mental integrity. The conclusion brings up considerations for future research.
Effects of maceration conditions on the polyphenolic composition of red wine 'Plavac mali'
Creators: name: Budić-Leto, I.
name: Garcin, L.
name: Lovrić, T.
name: Vrhovsek, U.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: The influence of the maceration treatments on the polyphenolic composition of red wines produced from Croatian autochthonous cultivar 'Plavac mali' (Vitis vinifera L.) has been investigated. The results showed that in general different skin contact times influenced the content of anthocyanins, total phenols and vanillin index in young wines. Prolonged skin contact time significantly increased the content of low molecular weight proanthocyanidins and decreased the content of anthocyanins. Young wine produced with maceration at lower temperature demonstrated the lower content of anthocyanins and proanthocyanins. No significant differences were observed between the levels of anthocyanins, total phenols and proanthocyanidins in wines aged for 14 months. Weaker colour intensity of 14-month-aged wines was detected in the wine made with prolonged skin maceration time in which the ratio of proanthocyanidins/anthocyanidins was the highest.
description: VITIS - Journal of Grapevine Research, Vol. 47 No. 4 (2008): Vitis
Syspasis puerulus
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Syspasis
Syspasis puerulus

description: Syspasis puerulus (KRIECHBAUMER, 1890)
M a t e r i a l e x a m i n e d: Trap8:1♁15-29.vi.
D i s t r i b u t i o n: Western Palaearctic, new record for Georgia and the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 106, DOI: 10.5281/zenodo.10788481
Tabular data insights and synthesis with the AutoTable approach
Creators: name: Spillner, Josef
Publisher: name: IEEE
Year: 2022
Subjects: Data intelligence
Beyond-schema inference
Pattern recognition
MLOps
005: Computerprogrammierung, Programme und Daten

description: AI convergence platforms such as Google's Unified AI Platform promise to fully interpret and understand any data submitted to them. The business needs of SMEs are however better addressed by tailored tools that smartly parse and interpret data without being locked into a particular vendor platform. With AutoTable, a new tool design for schema, pattern and relation inference as well as training data synthesis has recently become available. This paper explains why AutoTable is smart, unintrusive and yet powerful in working with tabular business data such as CSVs, flat JSON and spreadsheets.
An efficient buds culture method for the regeneration via somatic embryogenesis of table grapes 'Red Globe' and 'Flame Seedless'
Creators: name: Araya, S.
name: Prieto, H.
name: Hinrichsen, P.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: Research Note
description: VITIS - Journal of Grapevine Research, Vol. 47 No. 4 (2008): Vitis
title: The anomalous magnetic moment of the muon and the QED coupling at the Z boson mass
Creators: name: Liao, Ruofan
Publisher: name: University of Liverpool Repository
Year: 2012

description: In this thesis, we present our updated determinations for the leading order and higher order hadronic vacuum polarisation contributions to the anomalous magnetic moment of the muon (a_{\mu}^{had,LOVP}, a_{\mu}^{had,HOVP}), and for the hadronic contributions to the running of the QED coupling at the Z-boson mass (\Delta\alpha_{had}^{(5)}(M_Z^2)). At present the Standard Model (SM) predictions of the anomalous magnetic moment of the muon a_{\mu}^{SM} is lower than the experimental measurement a_{\mu}^{exp}$ by about 3 standard deviations. The precision of a_{\mu}^{SM} is limited by hadronic contributions, of which a_{\mu}^{had,LOVP} has the largest uncertainty. Therefore improving the accuracy and precision of a_{\mu}^{had,LOVP} will help to clarify the origin of the discrepancy between theory and experiment. The running of the QED coupling at the Z-boson mass \alpha(M_Z^2) is the least precise of the three parameters that is usually taken to define the electroweak sector of the SM. Its precision is limited by \Delta\alpha_{had}^{(5)}(M_Z^2), and is a significant limiting factor for precision electroweak physics, e.g. the indirect determination of Higgs boson mass. We describe in detail our refined data-driven approach, which processes and combines a large number of e^+e^- hadronic annihilation data for use in our determinations. Error treatment is of course, also discussed in depth. We present a detailed breakdown of all the contributions to a_{\mu}^{had,LOVP}, including the many new, more precise data used along with discussions on their impacts. We also perform an improved sum rule analysis for a specific energy region, which assists us in discriminating between two different choices of using data. Comparisons with previous analyses as well as with another group's recent determination are also made. For \Delta\alpha_{had}^{(5)}(M_Z^2), we summarise the main results, discussing their effects as well as the comparison with other groups. More focus is given to a separate procedure used for preparing a set of new data that will improve the description of \alpha(q^2). We conclude the thesis by summing our a_{\mu}^{had,LOVP}, a_{\mu}^{had,HOVP} results with the latest predictions of contributions from the other sectors of the SM, leading to our own value for a_{\mu}^{SM}. This is then discussed and compared to other recent determinations. Results for \Delta\alpha_{had}^{(5)}(M_Z^2) and \alpha(M_Z^2) are also briefly reviewed. Finally, a summary of the whole thesis and future prospects in this area of study are given.
A MAPE-K approach to autonomic microservices
Creators: name: Bucchiarone, Antonio
name: Guidi, Claudio
name: Lanese, Ivan
name: Bencomo, Nelly
name: Spillner, Josef
Publisher: name: IEEE
Year: 2022
Subjects: Autonomic computing
Microservices
Bluesky
Software architecture
005: Computerprogrammierung, Programme und Daten

description: Microservices are an emerging architectural style advocating for small loosely-coupled services in order to maximize scalability and adaptability. In order to help IT personnel, adaptability can be put (completely or partially) under the responsibility of the system using autonomic techniques, e.g., underpinned by a MAPE-K control loop. This paper discusses possible trade-offs, challenges, support techniques for software architects and research directions involved in building autonomic microservice-based systems.
Surface gravity waves from direct numerical simulations of the Euler equations: A comparison with second-order theory
Creators: name: Toffoli, Alessandro
name: Onorato, M.
name: Bitner-Gregersen, E. M.
name: Osborne, A. R.
name: Babanin, Alexander
Publisher: name: Swinburne
Year: 2024

description: When the wave spectrum is sufficiently narrow-banded and the wave steepness is sufficiently high, the modulational instability can take place and waves can be higher than expected from second-order wave theory. In order to investigate these effects on the statistical distribution of long-crested, deep water waves, direct numerical simulations of the Euler equations have been performed. Results show that, for a typical design spectral shape, both the upper and lower tails of the probability density function for the surface elevation significantly deviate from the commonly used second-order wave theory. In this respect, the crest elevation is observed to increase up to 18% at low probability levels. It would furthermore be expected that wave troughs become shallower due to nonlinear effects. Nonetheless, the numerical simulations show that the trough depressions tend to be deeper than in second-order theory.
title: Modelling of laser forming at macro and micro scales
Creators: name: Griffiths, J
Publisher: name: University of Liverpool Repository
Year: 2013

description: Laser forming (LF) offers industry the promise of controlled shaping of metallic and non-metallic components in prototyping, correction of design shape or distortion and precision adjustment applications. In order to fulfil this promise in a manufacturing environment the process must have a high degree of controllability, which can be achieved through a better understanding of its underlying mechanisms. The work presented in this thesis is primarily concerned with the use of modelling of the LF process at macro and micro scales as a means of process development. At the macro scale, finite element (FE), finite difference (FD) and analytical modelling were used to gain a better understanding of the complex interrelation between the various process parameters for specific geometries, reducing the need for extensive empirical investigations. A particular focus of the investigation was ascertaining which of these parameters influenced the fall off in bend angle per pass in multiple pass LF, along with the magnitude of their influence. The development of a full thermal-mechanical model of the LF process is detailed, as well as its application in a feasibility study into the forming of square section mild steel tubes for the automotive industry. Using this model, experimental observations were rationalized and novel scan strategies were developed which optimized the efficiency and accuracy of the process, something hitherto not possible using empirical methods alone. At the micro-scale, FE modelling was used to determine the mechanism of deformation in a novel laser micro-forming (LμF) technique, in conjunction with a full empirical study. The technique combined short pulse durations (20 ps) with high repetition rates (500 kHz) to generate localized heat build-up on the top surface of micro-scale stainless steel components, allowing for controlled and repeatable micro-adjustment. Modelling results suggest the mechanism works by confining the heating effect to the surface of the material, thereby selectively inducing thermal stresses and avoiding thermal damage of the component.
Development of a continuous respiration olfactometer for odorant delivery synchronous with natural respiration during recordings of brain electrical activity
Creators: name: Owen, Caroline M.
name: Patterson, John
name: Simpson, David
Publisher: name: Swinburne
Year: 2024

description: The continuous respiration olfactometer (CRO) was designed as a respiration-synchronous method for delivering odorants during recordings of brain electrical activity, providing control and monitoring of the timing of the delivery as well as the quantities of odorant involved. The CRO incorporates a purpose-built electronic system designed with very specific temporal and quantitative characteristics, and is composed of four main parts: the respiratory monitoring apparatus, the odorant/air delivery system, the serial interface device and the respiratory monitoring software. Tests were undertaken to determine the performance of the system with reference to the accuracy and precision of timing and control of odorant delivery. Tests were also undertaken to determine the effects of variations in natural respiration between subjects on the capability of the respiratory monitoring system, using a group of 50 subjects, to test the success of a variable gain control to optimize the range of the digitized respiratory output. The delivery system was able to provide information concerning quantities of air or odorant delivered, and the stimulus timing information required for integration with neurophysiological recording techniques.
Thyrateles haereticus
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Thyrateles
Thyrateles haereticus

description: Thyrateles haereticus (W ESMAEL, 1854)
M a t e r i a l e x a m i n e d: Trap4:1♁13-27.vii.; trap 7: 1♀ 20.v.-1.vi.
D i s t r i b u t i o n: Transpalaearctic, known from Caucasus region (RASNITSYN & SIYTAN 1981), new record for Georgia.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 107, DOI: 10.5281/zenodo.10788481