cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Target deconvolution of a multikinase inhibitor with antimetastatic properties identifies TAOK3 as a key contributor to a cancer stem cell-like phenotype
Creators: name: Rudloff, U.
name: Guha, R.
name: Bian, Y.
name: Ferrer, M.
name: Jiang, J.-K.
name: Aiken, T.J.
name: Shukla, V.
name: Patel, P.
name: Teper, Y.
name: Thomas, C.J.
name: Li, D.
name: Mathews Griner, L.A.
name: Xin, H.-W.
name: Aube, J.
name: Powers, A.S.
name: Rogers, S.A.
name: Shinn, P.
name: Pflicke, H.
Publisher: name: American Association for Cancer Research Inc.
Year: 2019

description: Pancreatic cancer remains an incurable condition. Its progression is driven, in part, by subsets of cancer cells that evade the cytotoxic effects of conventional chemotherapies. These cells are often low-cycling, multidrug resistant, and adopt a stem cell–like phenotype consistent with the concept of cancer stem cells (CSC). To identify drugs impacting on tumor-promoting CSCs, we performed a differential high-throughput drug screen in pancreatic cancer cells cultured in traditional (2D) monolayers versus three-dimensional (3D) spheroids which replicate key elements of the CSC model. Among the agents capable of killing cells cultured in both formats was a 1H-benzo[d]imidazol-2-amine–based inhibitor of IL2-inducible T-cell kinase (ITK; NCGC00188382, inhibitor #1) that effectively mediated growth inhibition and induction of apoptosis in vitro, and suppressed cancer progression and metastasis formation in vivo. An examination of this agent's polypharmacology via in vitro and in situ phosphoproteomic profiling demonstrated an activity profile enriched for mediators involved in DNA damage repair. Included was a strong inhibitory potential versus the thousand-and-one amino acid kinase 3 (TAOK3), CDK7, and aurora B kinases. We found that cells grown under CSC-enriching spheroid conditions are selectively dependent on TAOK3 signaling. Loss of TAOK3 decreases colony formation, expression of stem cell markers, and sensitizes spheroids to the genotoxic effect of gemcitabine, whereas overexpression of TAOK3 increases stem cell traits including tumor initiation and metastasis formation. By inactivating multiple components of the cell-cycle machinery in concert with the downregulation of key CSC signatures, inhibitor #1 defines a distinctive strategy for targeting pancreatic cancer cell populations.
Nonstandard Yukawa Couplings and Higgs Portal Dark Matter
Creators: name: Bishara, Fady
name: Brod, Joachim
name: Uttayarat, Patipan
name: Zupan, Jure
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the implications of non-standard Higgs Yukawa couplings to light quarks on Higgs-portal dark matter phenomenology. Saturating the present experimental bounds on up-quark, down-quark, or strange-quark Yukawa couplings, the predicted direct dark matter detection scattering rate can increase by up to four orders of magnitude. The effect on the dark matter annihilation cross section, on the other hand, is subleading unless the dark matter is very light -- a scenario that is already excluded by measurements of the Higgs invisible decay width. We investigate the expected size of corrections in multi-Higgs-doublet models with natural flavor conservation, the type-II two-Higgs-doublet model, the Giudice-Lebedev model of light quark masses, minimal flavor violation new physics models, Randall-Sundrum, and composite Higgs models. We find that an enhancement in the dark matter scattering rate of an order of magnitude is possible. Finally, we point out that a discovery of Higgs-portal dark matter could lead to interesting bounds on the light-quark Yukawa couplings.
description: 38 pages, 12 figures; minor mistake in numerics fixed, conclusions unchanged; references added
Additional file 1 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1 : Supplemental figure 1. Gating strategy for neutrophils, antigen-presenting cells, and the significant populations of lymphocytes in the lung. The percentages of natural killer (NK), invariant NKT cells (iNKT), and T Lc with a TCRgd were determined. Among APC, we identified alveolar macrophages (AM), inflammatory monocytes, patrolling monocytes, interstitial macrophages (IM), and conventional dendritic cells (cDC)1 and 2.
Bactericidal disruption of magnesium metallostasis in Mycobacterium tuberculosis is counteracted by mutations in the metal ion transporter CorA
Creators: name: Nathan, C.
name: Bacqué, E.
name: Quezada, L.L.
name: Ferron, M.
name: Liba, A.
name: Roubert, C.
name: Kelinske, M.
name: Kotev, M.
name: Couturier, C.
name: Zhang, J.
name: Little, D.
name: Roberts, J.
name: Goullieux, L.
name: Li, K.
name: Blanc, I.
name: Ling, Y.
name: Gold, B.
name: Aubé, J.
name: Lagrange, S.
name: Sans, S.
name: Debu, F.
name: Gonzalez, C.D.
name: Silve, S.
name: Pellet, A.
Publisher: name: American Society for Microbiology
Year: 2019

description: A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating Mycobacterium tuberculosis bacilli exhibiting phenotypic tolerance to most antibiotics in the standard treatment regimen. Confounding this problem is the increasing incidence of heritable multidrug-resistant M. tuberculosis. A search for new antimycobacterial chemical scaffolds that can kill phenotypically drug-tolerant mycobacteria uncovered tricyclic 4-hydroxyquinolines and a barbituric acid derivative with mycobactericidal activity against both replicating and nonreplicating M. tuberculosis. Both families of compounds depleted M. tuberculosis of intrabacterial magnesium. Complete or partial resistance to both chemotypes arose from mutations in the putative mycobacterial Mg2+/Co2+ ion channel, CorA. Excess extracellular Mg2+, but not other divalent cations, diminished the compounds’ cidality against replicating M. tuberculosis. These findings establish depletion of intrabacterial magnesium as an antimicrobial mechanism of action and show that M. tuberculosis magnesium homeostasis is vulnerable to disruption by structurally diverse, nonchelating, drug-like compounds.
Robust Surface States indicated by Magnetotransport in SmB6 Thin Films
Creators: name: Yong, Jie
name: Jiang, Yeping
name: Zhang, Xiaohang
name: Shin, Jongmoon
name: Takeuchi, Ichiro
name: Greene, Richard L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: SmB6 has been predicted and verified as a prototype of topological Kondo insulators (TKIs). Here we report longitudinal magnetoresistance and Hall coefficient measurements on co-sputtered nanocrystalline SmB6 films and try to find possible signatures of their topological properties. The magnetoresistance (MR) at 2 K is positive and linear (LPMR) at low field and becomes negative and quadratic at higher field. While the negative part is known from the reduction of the hybridization gap due to Zeeman splitting, the positive dependence is similar to what has been observed in other topological insulators (TI). We conclude that the LPMR is a characteristic feature of TI and is related to the linear dispersion near the Dirac cone. The Hall resistance shows a sign change around 50 K. It peaks and becomes nonlinear at around 10 K then decreases below 10 K. This indicates that carriers with opposite signs emerge below 50 K. Two films with different geometries (thickness and lateral dimension) show contrasting behavior below and above 50K, which proves the surface origin of the low temperature carriers in these films. The temperature dependence of magnetoresistance and the Hall data indicates that the surface states are likely non-trivial.
description: 16 pages, 4 figures
Additional file 4 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 4 : Supplemental figure 4. Effects of oral non-absorbable antibiotics on lung and spleen immune cell populations. (A) Flow cytometry of immune cells from lung homogenates in mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not. (B) Flow cytometry of immune cells from spleen homogenates in mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not. All experiments, group size 5 mice per group, results are shown as mean ± SD; *: p
Additional file 2 of Methanolic neem (Azadirachta indica) stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells in vitro
Creators: name: Kumar, Saurav
name: Mulchandani, Vaishali
name: Das Sarma, Jayasri
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: .
(502567) James Cornelius O'Dowd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The impact of the Electronic Fund Transfer Systems (EFTS) on banks performance in the Kingdom of Bahrain
Creators: name: Almeshari, Hessa
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 3502
subject: Banking, finance and investment

description: The Central Bank of Bahrain in conjunction with Benefit Company revolutionized the Electronic Fund Transfer System (EFTS) in 2015 with the sole aim of enhancing banks performance and increasing customer’s satisfaction. The main purpose of this study is to investigate the relationship between ROA, ROE, and fee-based income with the newly introduced Electronic Fund Transfer System (EFTS). The sample consisted of three commercial banks and three Islamic banks, with a target population consisting of an aggregate of all commercial banks and Islamic banks that are licensed and regulated by the Central Bank of Bahrain. This study used secondary data from banks annual reports and primary data from reports provided by Benefit Company. This study collected data for a period of four years spanning 2018 to 2021. The data collected is analyzed by using Stata and specifically using fixed effect model, random effect model, feasible generalized least squares (FGLS), Hausman test, and autocorrelation. The study revealed that there is a negative relationship between fee-based income and the values of the electronic fund transfer systems, and no impact on returns on assets and returns on equity.
Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine
Creators: name: Aubé, J.
name: Wix, K.
name: Trexler, K.R.
name: Siderovski, D.P.
name: Kinsey, S.G.
name: Kaski, S.W.
name: Gross, J.D.
name: Kenakin, T.
name: Setola, V.
name: White, A.N.
name: Harland, A.A.
name: Prisinzano, T.E.
Publisher: name: American Society for Pharmacology and Experimental Therapy
Year: 2019

description: Mu opioid receptor (MOR)-targeting analgesics are efficacious pain treatments, but notorious for their abuse potential. In preclinical animal models, coadministration of traditional kappa opioid receptor (KOR)-targeting agonists with MOR-targeting analgesics can decrease reward and potentiate analgesia. However, traditional KOR-targeting agonists are well known for inducing antitherapeutic side effects (psychotomimesis, depression, anxiety, dysphoria). Recent data suggest that some functionally selective, or biased, KOR-targeting agonists might retain the therapeutic effects of KOR activation without inducing undesirable side effects. Nalfurafine, used safely in Japan since 2009 for uremic pruritus, is one such functionally selective KOR-targeting agonist. Here, we quantify the bias of nalfurafine and several other KOR agonists relative to an unbiased reference standard (U50,488) and show that nalfurafine and EOM-salvinorin-B demonstrate marked G protein-signaling bias. While nalfurafine (0.015 mg/kg) and EOM-salvinorin-B (1 mg/kg) produced spinal antinociception equivalent to 5 mg/kg U50,488, only nalfurafine significantly enhanced the supraspinal analgesic effect of 5 mg/kg morphine. In addition, 0.015 mg/kg nalfurafine did not produce significant conditioned place aversion, yet retained the ability to reduce morphine-induced conditioned place preference in C57BL/6J mice. Nalfurafine and EOM-salvinorin-B each produced robust inhibition of both spontaneous and morphine-stimulated locomotor behavior, suggesting a persistence of sedative effects when coadministered with morphine. Taken together, these findings suggest that nalfurafine produces analgesic augmentation, while also reducing opioid-induced reward with less risk of dysphoria. Thus, adjuvant administration of G protein-biased KOR agonists like nalfurafine may be beneficial in enhancing the therapeutic potential of MOR-targeting analgesics, such as morphine.
Additional file 5 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5 : Supplemental figure 5. Effects of oral non-absorbable antibiotics on hematopoietic factors and bone marrow monocyte/dendritic cell progenitors. (A) ELISA of hematopoietic factors in serum of mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not, (B) Flow cytometry of monocyte/DC progenitors in the bone marrow in mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by fecal microbiota transplant (VAN/CST + FMT) or not. For all experiments, group size 5 mice per group; results are shown as mean ± SD; *: p
Additional file 1 of Sociodemographic and health status differences in delaying medical care during the COVID-19 pandemic among older adults: findings from the Health and Retirement Study
Creators: name: Farina, Mateo P.
name: Ailshire, Jennifer A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplemental Table 1. Odds Ratios from Logistic Regression Models Predicting Delayed Care Among Older Adults 54+ During the COVID-19 Pandemic (HRS COVID Subsample 2020).
(502560) Violet Astley Sparke
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 3 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3 : Supplemental figure 3. Bacterial family as percentages of sequenced 16S rDNA in the lung and gut. Mice were treated or not by oral vancomycin (VAN), and colistin (CST) followed or not by fecal microbiota transplant (FMT) and infected or not by P. aeruginosa PAO1 (n = 2 per group).
Current conservation in electrodisintegration of a bound system in the Bethe-Salpeter approach
Creators: name: Karmanov, V. A.
name: Carbonell, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Using our solutions of the Bethe-Salpeter equation with OBE kernel in Minkowski space both for the bound and scattering states, we calculate the transition form factors for electrodisintegration of the bound system which determine the electromagnetic current J of this process. Special emphasis is put on verifying the gauge invariance which should manifest itself in the current conservation. We find that for any value of the momentum transfer q the contributions of the plane wave and the final state interaction to the quantity J.q cancel each other thus providing J.q=0. However, this cancellation is obtained only if the initial Bethe-Salpeter amplitude (bound state), the final one (scattering state) and the current operator are strictly consistent with each other. A reliable result for the transition form factor can be found only in this case.
description: 7 pages, 5 figures. Contribution to the proceedings of the Workshop: Light-Cone 2014, Raleigh, North Carolina, USA, May 26-30, 2014. To be published in Few-Body Systems
K+'s Collective Flow in Heavy-ion Collisions predicted by Covariant Kaon Dynamics
Creators: name: Xing, Yong-Zhong
name: Dai, Yue-Qian
name: Zheng, Yu-Ming
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The directed and elliptic flows of positively charged Kaon produced in $^{58}_{28}$Ni + $^{58}_{28}$Ni reaction at incident kinetic energy 1.91 AGeV, experimental data are released newly by V. Zinyuk,et.al. in Ref.[arXiv: 1403.1504v2 [nucl-ex] 8 Apr 2014], are reproduced by using the covariant kaon dynamics. Our numerical results indicate qualitatively the Lorentz force is necessary to explained reasonably the data as soon as the space-like part of kaon's vector potential is involved. The sensitivity of $K^+$ directed as well as differential directed flow on the Lorentz force are also observed near target rapidity.
description: arXiv admin note: text overlap with arXiv:nucl-th/9812001 by other authors
Additional file 1 of Prevalence and molecular characteristics of Staphylococcus aureus in raw milk and milk products in Ethiopia: a systematic review and meta-analysis
Creators: name: Deddefo, Abiot
name: Mamo, Gezahegne
name: Leta, Samson
name: Amenu, Kebede
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1. PRISMA checklist
(502564) [Lady] Emily Kingscote
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synthesis of the Nonribosomal Peptide Phevalin and Analogs
Creators: name: Ramesh, R.
name: Zeng, Y.
name: Bovino, M.T.
name: Aubé, J.
Publisher: name: American Chemical Society
Year: 2019

description: Phevalin, a cyclic nonribosomal peptide produced by Staphylococcus aureus, has intriguing biological properties. A synthetic route to access phevalin and similar pyrazinone natural products tyrvalin, leuvalin, phileucin, and a few synthetic analogs is described. The reaction sequence involves a one-pot carbamate deprotection/imine formation/aerobic oxidation to form the pyrazinone-containing products.
Relic Abundance of Asymmetric Dark Matter and the Scalar--Tensor Model
Creators: name: Wang, Shun-zhi
name: Iminniyaz, Hoernisa
name: Mamat, Mamatrishat
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The relic abundance of asymmetric Dark Matter particles in the scalar--tensor model is analysized in this article. We extend the numeric and analytic calculation of the relic density of the asymmetric Dark Matter in the standard cosmological scenario to the nonstandard cosmological scenario. We focus on the scalar--tensor model. Hubble expansion rate is changed in the nonstandard cosmological scenario. This leaves its imprint on the relic density of Dark Matter particles. In this article we investigate to what extent the asymmetric Dark Matter particle's relic density is changed in the scalar--tensor model. We use the observed present day Dark Matter abundance to find the constraints on the parameter space in this model.
description: The whole structure of the paper is changed. The new figure is added and typos are corrected
(502565) [Mrs] Barrington Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Prevalence and molecular characteristics of Staphylococcus aureus in raw milk and milk products in Ethiopia: a systematic review and meta-analysis
Creators: name: Deddefo, Abiot
name: Mamo, Gezahegne
name: Leta, Samson
name: Amenu, Kebede
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2. Forest plot of S. aureus prevalence in raw cow milk
Die Landesinitiative openaccess.nrw
Creators: name: Schönfelder, Nina
Publisher: name: Kolloquium Wissensinfrastruktur
Year: 2023

description: Im April 2022 hat die Landesinitiative openaccess.nrw offiziell ihre Arbeit aufgenommen. Als zentrale Serviceeinrichtung und Koordinierungsstelle rund um das Thema Open Access für die Hochschulen in NRW steht sie allen Akteur:innen aus dem Handlungsfeld Open Access als Ansprechpartnerin zur Verfügung: Bibliotheken, Hochschulleitungen, Forschungsdezernaten, strategischen Entscheider:innen und Infrastruktureinrichtungen. Die Services wurden auf drei inhaltliche Kompetenzbereiche aufgeteilt, die im Verantwortungsbereich unterschiedlicher Institutionen liegen. Der Programmbereich 1 umfasst ein allgemeines Beratungsangebot, die Bereitstellung von Informationen rund um die Themen Open Access und wissenschaftliches Publizieren sowie die Gesamtkoordination des Projekts (Universität Duisburg-Essen). Das Hochschulbibliothekszentrum des Landes Nordrhein-Westfalen (hbz) (Programmbereich 2) arbeitet an der Implementierung von zentralen Infrastrukturservices für Open-Access-Publikationen im Hochschulbereich. Der Programmbereich 3 umfasst das Thema Monitoring und wird von der Universität Bielefeld geleitet. Das Konsortium der Landesinitiative openaccess.nrw besteht aus Universitäten, Fach-, Kunst- und Musikhochschulen in NRW, dem hbz sowie der ZB MED, die gemeinsam die strategisch-operative Begleitgruppe des Projekts bilden. Die AG Openness dient als Beirat. Das Projekt wird über die digitale Hochschule NRW (DH.NRW) bis Ende 2025 durch das Ministerium für Kultur und Wissenschaft NRW gefördert.
description: Kolloquium Wissensinfrastruktur, Wintersemester 2022/23
Additional file 6 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 6 : Supplemental figure 6. Effects of Flt3-Ligand on lung immune cell populations and on outcomes of lung infection. (A) Flow cytometry of monocyte/DC progenitors in the bone marrow of mice treated or not (controls) with 7-days oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not, (B) Flow cytometry of immune cells from lungs of mice with 7-days oral vancomycin/colistin (VAN/CST) followed by systemic Flt3-Ligand administration (VAN/CST + Flt3-L) or not. For all experiments, group size 5 mice per group; results are shown as mean ± SD; *: p
(502544) Sarah Harding
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The impact of capital adequacy on bank profitability:Evidence from retail banks listed on Bahrain Bourse
Creators: name: KAZROONI, HUSAIN
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 3502
subject: Banking, finance and investment
classificationCode: 350202
subject: Finance

description: The financial industry plays a significant role in the economy of Bahrain, as of 2020 it contributes to 17.9% of the total GDP. Due to its significance, this study aims to analyze the impact of capital adequacy on bank profitability using quantitative data retrieved from financial statements of retail banks listed on Bahrain Bourse. This paper uses information from the Federal Reserve, Basel framework and Central Bank of Bahrain rulebook regarding rules and regulations to understand bank capital and capital requirements. The measure of capital adequacy used in this study is the capital adequacy ratio while the profitability measures are return on assets and return on equity. This study aims to analyze the impact through data panel regression using a period of seven years from 2015 to 2021. Through review of literature and simple linear regression, the results showed a significant and positive relationship between capital adequacy and return on assets, and an insignificant relationship between capital adequacy and return on equity.
Slowly rotating bars-Morphologies introduced by bistability in barred-spiral galactic potentials
Creators: name: Tsigaridi, L.
name: Patsis, P. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the orbital dynamics of a \textit{barred-spiral} model when the system is rotating slowly and corotation is located beyond the end of the spiral arms. In the characteristic of the central family of periodic orbits we find a "bistable region". In the response model we observe a ring surrounding the bar and spiral arms starting tangential to the ring. This is a morphology resembling barred-spiral systems with inner rings. However, the dynamics associated with this structure in the case we study is different from that of a typical bar ending close to corotation. The ring of our model is round, or rather elongated perpendicular to the bar. It is associated with a folding (an "S" shaped feature) of the characteristic of the central family, which is typical in bistable bifurcations. Along the "S" part of the characteristic we have a change in the orientation of the periodic orbits from a x1-type to a x2-type morphology. The orbits populated in the response model change rather abruptly their orientation when reaching the lowest energy of the "S". The spirals of the model follow a standard "precessing ellipses flow" and the orbits building them have energies beyond the "S" region. The bar is structured mainly by sticky orbits from regions around the stability islands of the central family. This leads to the appearance of X-features in the bars \textit{on} the galactic plane. Such a bar morphology appears in the unsharp-masked images of some moderately inclined galaxies.
description: MNRAS in press, 12 pages, 14 figures
Additional file 3 of Prevalence and molecular characteristics of Staphylococcus aureus in raw milk and milk products in Ethiopia: a systematic review and meta-analysis
Creators: name: Deddefo, Abiot
name: Mamo, Gezahegne
name: Leta, Samson
name: Amenu, Kebede
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3. Forest plot of S. aureus prevalence in camel, goat and pasteurized milk
Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy
Creators: name: Smith, M.D.
name: Bovino, M.
name: Xu, Y.-P.
name: Liu, Y.
name: Li, Z.
name: Tan, X.-M.
name: Li, W.-C.
name: Xiong, Y.
name: Aubé, J.
name: Cheng, M.
name: Lv, L.
Publisher: name: American Society for Clinical Investigation
Year: 2019

description: Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently in hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced activity. The impact of decreased TET activity in solid tumors is not known. Here we show that TET2 mediates the IFN-γ/JAK/STAT signaling pathway to control chemokine and PD-L1 expression, lymphocyte infiltration, and cancer immunity. IFN-γ stimulated STAT1 to bind TET2 and recruit TET2 to hydroxymethylate chemokine and PD-L1 genes. Reduced TET activity was associated with decreased Th1-type chemokines and tumorinfiltrating lymphocytes and the progression of human colon cancer. Deletion of Tet2 in murine melanoma and colon tumor cells reduced chemokine expression and tumor-infiltrating lymphocytes, enabling tumors to evade antitumor immunity and to resist anti-PD-L1 therapy. Conversely, stimulating TET activity by systematic injection of its cofactor ascorbate/Vitamin C increased chemokines and tumor-infiltrating lymphocytes, leading to enhanced antitumor immunity and anti-PD-L1 efficacy and extended lifespan of tumor-bearing mice. These results suggest an IFN-γ/JAK/STAT/TET signaling pathway that mediates tumor response to anti-PD-L1/PD-1 therapy and is frequently disrupted in solid tumors. Our findings also suggest TET activity as a biomarker for predicting the efficacy of and patient response to anti-PD-1/PD-L1 therapy, and stimulation of TET activity as an adjuvant immunotherapy of solid tumors.
(502553) Henry sen Machin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Microwave Discharge Ion Sources
Creators: name: Celona, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: This chapter describes the basic principles, design features and characteristics of microwave discharge ion sources. A suitable source for the production of intense beams for high-power accelerators must satisfy the requirements of high brightness, stability and reliability. The 2.45 GHz off-resonance microwave discharge sources are ideal devices to generate the required beams, as they produce multimilliampere beams of protons, deuterons and singly charged ions. A description of different technical designs will be given, analysing their performance, with particular attention being paid to the quality of the beam, especially in terms of its emittance.
description: 21 pages, contribution to the CAS-CERN Accelerator School: Ion Sources, Senec, Slovakia, 29 May - 8 June 2012, edited by R. Bailey
Additional file 7 of Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice
Creators: name: Dessein, Rodrigue
name: Bauduin, Marvin
name: Grandjean, Teddy
name: Guern, Rémi Le
name: Figeac, Martin
name: Beury, Delphine
name: Faure, Karine
name: Faveeuw, Christelle
name: Benoit Guery
name: Gosset, Philippe
name: Kipnis, Eric
Publisher: name: figshare
Year: 2020
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 7.
THE IMPACT OF CAPITAL ADEQUACY ON BANK PROFITABILITY: EVIDENCE FROM RETAIL BANKS LISTED ON BAHRAIN BOURSE
Creators: name: KAZROONI, HUSAIN
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 3502
subject: Banking, finance and investment
classificationCode: 350202
subject: Finance

description: The financial industry plays a significant role in the economy of Bahrain, as of 2020 it contributes to 17.9% of the total GDP. Due to its significance, this study aims to analyze the impact of capital adequacy on bank profitability using quantitative data retrieved from financial statements of retail banks listed on Bahrain Bourse. This paper uses information from the Federal Reserve, Basel framework and Central Bank of Bahrain rulebook regarding rules and regulations to understand bank capital and capital requirements. The measure of capital adequacy used in this study is the capital adequacy ratio while the profitability measures are return on assets and return on equity. This study aims to analyze the impact through data panel regression using a period of seven years from 2015 to 2021. Through review of literature and simple linear regression, the results showed a significant and positive relationship between capital adequacy and return on assets, and an insignificant relationship between capital adequacy and return on equity.
Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma
Creators: name: Nathan, C.F.
name: Dartois, V.
name: Zimmerman, M.
name: Nguyen, Q.
name: Smith, R.
name: Porubsky, P.
name: Gold, B.S.
name: Perkowski, A.J.
name: Schoenen, F.J.
name: Ho-Liang, H.-P.
name: McDonald, S.L.
name: Zhang, D.
name: Pharr, C.W.
name: Aubé, J.
Publisher: name: Nature Publishing Group
Year: 2019

description: A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
title: Διαδερμική Βιοψία υπό Αξονικό Τομογράφο Κατευθυνόμενη με το σύστημα πλοήγησης Imactis
title: Percutaneous Biopsy under Computed Tomography Guided by the Imactis Electromagnetic Navigation System
titleType: AlternativeTitle
Creators: name: Βούρθης, Άγγελος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Συστήματα πλοήγησης
Ηλεκτρομαγνητικό σύστημα πλοήγησης
Οπτικό σύστημα πλοήγησης
Imactis
Διαδερμική βιοψία
Επεμβατικές πράξεις υπό αξονικό τομογράφο
Δόσεις
Αριθμός σαρώσεων
Διάρκεια επεμβάσεων
Επεμβατική ακτινολογία

description: ΣΚΟΠΟΣ: Η σύγκριση των αποτελεσμάτων του συστήματος ηλεκτρομαγνητικής πλοήγησης IMACTIS σε σχέση με τη συμβατική καθοδήγηση για βιοψίες καθοδηγούμενες υπό αξονική τομογραφία (CT), καθώς και ανάλυση των αποτελεσμάτων. ΥΛΙΚΟ-ΜΕΘΟΔΟΣ: Ελήφθησαν δεδομένα τόσο από βιβλιογραφικές μελέτες όσο και από το τμήμα αξονικής τομογραφίας του ΠΓΝΑ ΑΤΤΙΚΟΝ που αφορούν σε απεικονιστικά κατευθυνόμενες CT βιοψίες που πραγματοποιήθηκαν είτε με συμβατική λήψη δεδομένων ή μέσω του συστήματος IMACTIS . Το σύστημα πλοήγησης αξιολογήθηκε κυρίως σε βιοψίες ήπατος μεταξύ των δύο ομάδων περιστατικών όπου συγκρίθηκαν ο αριθμός των ληφθέντων σαρώσεων, ο συνολικός χρόνος μεταξύ πρώτης και τελευταίας σάρωσης, καθώς και οι δοσιμετρικοί δείκτες CTDIvol (CT Dose Index) και DLP (Dose Length Product) που αφορούν στην ακτινική επιβάρυνση των εξεταζομένων. Ακόμα παρατίθενται χαρακτηριστικά παρόμοιων συστημάτων προώθησης βελόνας και συγκρίνονται ως προς τα πλεονεκτήματα και τα μειονεκτήματα που παρουσιάζει το καθένα. ΑΠΟΤΕΛΕΣΜΑΤΑ: Στα δεδομένα που αντλήθηκαν από βιβλιογραφικές μελέτες παρατηρείται ότι η απουσία συστήματος πλοήγησης οδηγεί σε αύξηση εύρους 12,5-135,2% στον αριθμό των σαρώσεων, αύξηση του χρόνου μεταξύ της πρώτης και της τελευταίας σάρωσης με εύρος 3,57-50% και αύξηση της συνολικής DLP δόσης με εύρος 32-320%. Στα δεδομένα που αντλήθηκαν από το ΠΓΝΑ ΑΤΤΙΚΟΝ για βιοψίες ήπατος υπό αξονικό τομογράφο 64 τομών παρατηρείται αύξηση στον αριθμό των σαρώσεων >75%, αύξηση >38% του χρόνου μεταξύ της πρώτης και της τελευταίας σάρωσης, ο δείκτης CTDIvol παραμένει σχετικά σταθερός, ενώ ο δείκτης DLP παρουσιάζει αύξηση >11%. ΣΥΜΠΕΡΑΣΜΑΤΑ: Το σύστημα πλοήγησης για βιοψίες καθοδηγούμενες με αξονική τομογραφία επιτρέπει τη διενέργεια βιοψιών με το ίδιο διαγνωστικό ποσοστό επιτυχίας με τη συμβατική τεχνική αλλά με σημαντικά μικρότερο αριθμό απαιτούμενων σαρώσεων που σημαίνει σημαντικά χαμηλότερη ακτινική επιβάρυνση του εξεταζόμενου και μικρότερη χρονική διάρκεια για την ολοκλήρωση της επεμβατικής διαδικασίας.
Additional file 4 of Prevalence and molecular characteristics of Staphylococcus aureus in raw milk and milk products in Ethiopia: a systematic review and meta-analysis
Creators: name: Deddefo, Abiot
name: Mamo, Gezahegne
name: Leta, Samson
name: Amenu, Kebede
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 4. Forest plot of S. aureus prevalence in local cheese and fermented milk
Characterization of maximally random jammed sphere packings: Voronoi correlation functions
Creators: name: Klatt, Michael Andreas
name: Torquato, Salvatore
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences
subject: 82B21, 82B44, 82D30, 82D15, 60G55, 62M30, 62H05, 62H20, 53C65, 05B40, 05B45, 52B05

description: We characterize the structure of maximally random jammed (MRJ) sphere packings by computing the Minkowski functionals (volume, surface area, and integrated mean curvature) of their associated Voronoi cells. The probability distribution functions of these functionals of Voronoi cells in MRJ sphere packings are qualitatively similar to those of an equilibrium hard-sphere liquid and partly even to the uncorrelated Poisson point process, implying that such local statistics are relatively structurally insensitive. This is not surprising because the Minkowski functionals of a single Voronoi cell incorporate only local information and are insensitive to global structural information. To improve upon this, we introduce descriptors that incorporate nonlocal information via the correlation functions of the Minkowski functionals of two cells at a given distance as well as certain cell-cell probability density functions. We evaluate these higher-order functions for our MRJ packings as well as equilibrium hard spheres and the Poisson point process. We find strong anticorrelations in the Voronoi volumes for the hyperuniform MRJ packings, consistent with previous findings for other pair correlations [A. Donev et al., Phys. Rev. Lett. 95, 090604 (2005)], indicating that large-scale volume fluctuations are suppressed by accompanying large Voronoi cells with small cells, and vice versa. In contrast to the aforementioned local Voronoi statistics, the correlation functions of the Voronoi cells qualitatively distinguish the structure of MRJ sphere packings (prototypical glasses) from that of the correlated equilibrium hard-sphere liquids. Moreover, while we did not find any perfect icosahedra (the locally densest possible structure in which a central sphere contacts 12 neighbors) in the MRJ packings, a preliminary Voronoi topology analysis indicates the presence of strongly distorted icosahedra.
description: 13 pages, 10 figures
Human antigen R as a therapeutic target in pathological cardiac hypertrophy
Creators: name: Wu, X.
name: Green, L.C.
name: Roy, S.
name: Benoit, J.B.
name: Tranter, M.
name: Rubinstein, J.
name: Jones, S.M.
name: Lanzillotta, L.
name: Blaxall, B.C.
name: Owens, A.P.
name: Anthony, S.R.
name: Aube, J.
name: Robbins, N.
name: Nieman, M.L.
name: Xu, L.
name: Lorenz, J.N.
name: Slone, S.
Publisher: name: NLM (Medline)
Year: 2019

description: RNA binding proteins represent an emerging class of proteins with a role in cardiac dysfunction. We show that activation of the RNA binding protein human antigen R (HuR) is increased in the failing human heart. To determine the functional role of HuR in pathological cardiac hypertrophy, we created an inducible cardiomyocyte-specific HuR-deletion mouse and showed that HuR deletion reduces left ventricular hypertrophy, dilation, and fibrosis while preserving cardiac function in a transverse aortic constriction (TAC) model of pressure overload-induced hypertrophy. Assessment of HuR-dependent changes in global gene expression suggests that the mechanistic basis for this protection occurs through a reduction in fibrotic signaling, specifically through a reduction in TGF-β (Tgfb) expression. Finally, pharmacological inhibition of HuR at a clinically relevant time point following the initial development of pathological hypertrophy after TAC also yielded a significant reduction in pathological progression, as marked by a reduction in hypertrophy, dilation, and fibrosis and preserved function. In summary, this study demonstrates a functional role for HuR in the progression of pressure overload-induced cardiac hypertrophy and establishes HuR inhibition as a viable therapeutic approach for pathological cardiac hypertrophy and heart failure.
Additional file 1 of Validation of the REduction of Atherothrombosis for Continued Health (REACH) prediction model for recurrent cardiovascular disease among United Arab Emirates Nationals
Creators: name: Al-Shamsi, Saif
name: Govender, Romona D.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1: Table S1. Frequency of recurrent CVD eventsa and cardiovascular deathb.
(502559) George Lord Bingham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.