cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating cultural conflicts in everyday self-care among Chinese first-time pregnant migrants in Australia
Creators: name: Zhi, Xiaojuan
name: McKenzie-McHarg, Kirstie
name: Mai, Jimmy
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4204
subject: Midwifery
classificationCode: 3215
subject: Reproductive medicine
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences

description: Abstract:- 
Background:Given the fast-growing migration and globalisation trends in the last decades, women increasingly experienced pregnancy as migrants and often faced complex and unique challenges related to both migration and pregnancy in a foreign land, affecting their psychological wellbeing during pregnancy. Cultural conflicts between pregnant migrants’ home and host cultures could play a critical role affecting their pregnancy experiences and psychological wellbeing. 
Aims: This study aimed to explore cultural conflicts that challenge Chinese first-time expectant mothers living in Australia regarding their pregnancy self-care and their psychological wellbeing. 
Method: A qualitative methodology was adopted utilising interpretative phenomenological analysis. Participants were 18 Chinese-born first-time pregnant migrants in Australia. A semi-structured interview schedule focused on their pregnancy self-care and psychological wellbeing and any effects of Chinese-Western/Australian cultural conflicts. 
Findings: Two psychosocial approaches were identified to explain how all the participants were psychologically challenged by self-care cultural conflicts to some extent: 1) challenging decision-making processes about self-care cultural conflicts and 2) interpersonal tension if the decisions conflicted with someone's advice/beliefs/opinions. 
Conclusion: Emotional, cognitive, and social factors were relevant in shaping the participants’ engagement with and their experiences of various pregnancy self-care activities.
Additional file 1 of Characterizing and quantifying low-value diagnostic imaging internationally: a scoping review
Creators: name: Kjelle, Elin
name: Andersen, Eivind Richter
name: Krokeide, Arne Magnus
name: Soril, Lesley J. J.
name: van Bodegom-Vos, Leti
name: Clement, Fiona M.
name: Hofmann, Bjørn Morten
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Search strategy and hits.
Buprenorphine extended-release injection (Brixadi®) in the management of opioid use disorder: a profile of its use in the USA
Creators: name: Blair, Hannah A.
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest Hannah Blair is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.

Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.

Additional information about this Adis Drug Review can be found here. 

Abstract
Buprenorphine extended-release (ER) injection for subcutaneous use (Brixadi®; CAM2038; hereafter referred to as buprenorphine ER) is a useful addition to the treatment options for opioid use disorder (OUD). Brixadi® is formulated using FluidCrystal® injection depot technology, allowing for a low volume prefilled syringe and steady release of buprenorphine over one week or one month. In a pivotal phase 3 trial, weekly or monthly subcutaneous buprenorphine ER was non-inferior to daily sublingual buprenorphine/naloxone in terms of the proportion of opioid-negative urine samples and the responder rate. Based on the cumulative distribution function of the percentage of opioid-negative samples, superiority was demonstrated with subcutaneous buprenorphine ER compared with sublingual buprenorphine/naloxone. In the DEBUT trial, patients who received subcutaneous buprenorphine ER reported higher and more sustained treatment satisfaction than those who received sublingual buprenorphine. Real-world studies have also demonstrated high levels of satisfaction with buprenorphine ER in patients with opioid dependence. Buprenorphine ER was generally well tolerated, with a systemic safety profile similar to that of sublingual buprenorphine/naloxone. The most common treatment-emergent adverse events were injection-site reactions.

© Springer Nature Switzerland AG 2024
Composite Robust Estimators for Linear Mixed Models
Creators: name: Agostinelli, Claudio
name: Yohai, Víctor J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The classical Tukey–Huber contamination model (CCM) is a commonly adopted framework to describe the mechanism of outliers generation in robust statistics. Given a dataset with n observations and p variables, under the CCM, an outlier is a unit, even if only one or a few values are corrupted. Classical robust procedures were designed to cope with this type of outliers. Recently, a new mechanism of outlier generation was introduced, namely, the independent contamination model (ICM), where the occurrences that each cell of the data matrix is an outlier are independent events and have the same probability. ICM poses new challenges to robust statistics since the percentage of contaminated rows dramatically increase with p, often reaching more than 50% whereas classical affine equivariant robust procedures have a breakdown point of 50% at most. For ICM, we propose a new type of robust methods, namely, composite robust procedures that are inspired by the idea of composite likelihood, where low-dimension likelihood, very often the likelihood of pairs, are aggregated to obtain a tractable approximation of the full likelihood. Our composite robust procedures are built on pairs of observations to gain robustness in the ICM. We propose composite τ-estimators for linear mixed models. Composite τ-estimators are proved to have a high breakdown point both in the CCM and ICM. A Monte Carlo study shows that while classical S-estimators can only cope with outliers generated by the CCM, the estimators proposed here are resistant to both CCM and ICM outliers. Supplementary materials for this article are available online.
Study of remote sensing and GIS for the assessment of their capabilities in mapping the vegetation form and structure of tropical savannas in Northern Australia
Creators: name: Khwaja, Zulfiquar
Publisher: name: Charles Darwin University
Year: 2001

description: The aim of this thesis was to investigate various methods of mapping land cover types in the savannas of northern Australia by using remotely sensed imageries and GIS tools. The questions were about the type and resolution of imageries as well as the digital image analysis methodology that would best map the land cover types of the region. Several image classification techniques in combination with various resolution imageries were used to classify land cover types in semi arid savannas at various study sites in the Victoria River District of the Northern Territory of Australia. The efficacy of the data sets and the techniques was tested at several study sites, most notably Kidman Springs Research Station and Mathison Station. Various combinations of imagery and digital image analysis methods were used at the Kidman Springs site. These were then used to predictively classify land cover types at the Mathison study area. This was done to test the validity of the image analysis techniques used at the Kidman Springs site in a wetter and more densely vegetated area as well as to test the influence of these environmental parameters on the classification results. It was consistently found that the finer resolution imagery (SPOT XS) combined with an unsupervised classification technique best performed in differentiating the major land cover types in both the study sites. Overall classification accuracy was in the vicinity of 65%-80%. The classification results at the Mathison area was poorer than the Kidman Springs site largely because of the influence of the more rugged and varied terrain at the later region. A GIS analysis technique using a digital elevation model (DEM), however, enhanced the classification accuracy considerably by reducing the ambiguity in the classified imageries. A method of spectral signature extrapolation was developed from the Kidman Springs data set, and applied as a classification mask to Mathison study site and to a larger surrounding region. This worked reasonably well in mapping the major land cover types of the wider region, although there were some limitations. As a whole, the problems of land cover classification in the region were not entirely methodological. Rather, the problem of digital image classification for land cover mapping in the savannas of the region lies largely in the definition and delineation of the land cover classes of the region. The classification scheme available for defining and delineating the land cover class boundaries in the region was based on the spatial characteristics of the land cover types. It is hypothesised that a redefinition of the land cover types of the region on the basis of the spectral characteristics of the components of the land covers will produce improved classification accuracy in the region.
Additional file 2 of Characterizing and quantifying low-value diagnostic imaging internationally: a scoping review
Creators: name: Kjelle, Elin
name: Andersen, Eivind Richter
name: Krokeide, Arne Magnus
name: Soril, Lesley J. J.
name: van Bodegom-Vos, Leti
name: Clement, Fiona M.
name: Hofmann, Bjørn Morten
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 2. Excluded studies.
Vom Thesaurus zum semantischen Netz. Potenziale von Data Mining in bibliographischen Datensätzen
Creators: name: Hartmann, Andreas
name: Thänert, Sabine
Publisher: name: Digital Classics Online
Year: 2015

description: The paper explores the potential of data mining in bibliographic records. Quantitative analsysis of co-occurrences of keywords in bibliographic records makes it possible to create a semantic network. In contrast to the rigid hierarchy of traditional thesauri, this network maps polyvalent semantic relations between keywords across the distinct thematic branches of a thesaurus tree. Analysis of a comprehensive data pool made up from two major bibliographies (Gnomon Bibliographic Database and ZENON DAI) should allow for the semantic mapping of a core set of central topics (people, places, social structures, concepts) of classical scholarship.
description: Digital Classics Online, Bd. 1,1 (2015)
Additional file 3 of Characterizing and quantifying low-value diagnostic imaging internationally: a scoping review
Creators: name: Kjelle, Elin
name: Andersen, Eivind Richter
name: Krokeide, Arne Magnus
name: Soril, Lesley J. J.
name: van Bodegom-Vos, Leti
name: Clement, Fiona M.
name: Hofmann, Bjørn Morten
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Sociology
subject: FOS: Sociology

description: Additional file 3. Characteristics of the included studies.
Reduced Insulin Resistance and Oxidative Stress in a Mouse Model of Metabolic Syndrome following Twelve Weeks of Citrus Bioflavonoid Hesperidin Supplementation: A Dose–Response Study
Creators: name: Jamal, Abdulsatar
name: Brettle, Holly
name: Jamil, Dina A
name: Tran, Vivian
name: Diep, Henry
name: Bobik, Alexander
name: van der Poel, Chris
name: Vinh, Antony
name: Drummond, Grant R
name: Thomas, Colleen
name: Jelinic, Maria
name: Al-Aubaidy, Hayder
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 3206
subject: Medical biotechnology
subject: FOS: Medical biotechnology

description: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities affecting ~25% of adults and is linked to chronic diseases such as cardiovascular disease, cancer, and neurodegenerative diseases. Oxidative stress and inflammation are key drivers of MetS. Hesperidin, a citrus bioflavonoid, has demonstrated antioxidant and anti-inflammatory properties; however, its effects on MetS are not fully established. We aimed to determine the optimal dose of hesperidin required to improve oxidative stress, systemic inflammation, and glycemic control in a novel mouse model of MetS. Male 5-week-old C57BL/6 mice were fed a high-fat, high-salt, high-sugar diet (HFSS; 42% kcal fat content in food and drinking water with 0.9% saline and 10% high fructose corn syrup) for 16 weeks. After 6 weeks of HFSS, mice were randomly allocated to either the placebo group or low- (70 mg/kg/day), mid- (140 mg/kg/day), or high-dose (280 mg/kg/day) hesperidin supplementation for 12 weeks. The HFSS diet induced significant metabolic disturbances. HFSS + placebo mice gained almost twice the weight of control mice (p < 0.0001). Fasting blood glucose (FBG) increased by 40% (p < 0.0001), plasma insulin by 100% (p < 0.05), and HOMA-IR by 150% (p < 0.0004), indicating insulin resistance. Hesperidin supplementation reduced plasma insulin by 40% at 140 mg/kg/day (p < 0.0001) and 50% at 280 mg/kg/day (p < 0.005). HOMA-IR decreased by 45% at both doses (p < 0.0001). Plasma hesperidin levels significantly increased in all hesperidin groups (p < 0.0001). Oxidative stress, measured by 8-OHdG, was increased by 40% in HFSS diet mice (p < 0.001) and reduced by 20% with all hesperidin doses (p < 0.005). In conclusion, hesperidin supplementation reduced insulin resistance and oxidative stress in HFSS-fed mice, demonstrating its dose-dependent therapeutic potential in MetS.
Legal Issues in Computational Research Using Text and Data Mining: An Interactive Workshop
Creators: name: Hansen, Dave
name: Brooke, Rachel
Publisher: name: Unknown
Year: 2024
Subjects: subject: Text and data mining, Computational research, Copyright, Fair use

description: Computational research techniques such as text and data mining (TDM) hold tremendous opportunities for researchers across the disciplines, ranging from mining scientific articles to create better systematic reviews to building a corpus of films to understand how concepts of gender, race, and identity are shared over time. Unfortunately, legal uncertainty associated with text and data mining can stifle this research. Recent copyright lawsuits, such as the high-profile cases brought against Microsoft, Github, and StabiltyAI underscore the legal complications. This workshop will survey existing law and policy and highlight pathways forward for researchers and librarians, including fair use and TDM-specific exemptions to copyright, particularly for users of materials covered by digital rights management (DRM) and other similar technology. We will also discuss limitations of the law and explore ways in which it might be improved, as well as practical issues such as licensing of content for TDM use. The workshop will be led by Dave Hansen and Rachel Brooke of Authors Alliance, a nonprofit that exists to support authors who research and write for public benefits. Dave and Rachel are copyright experts who have worked extensively on legal barriers to research. They have served as co-PIs for the Authors Alliance Text and Data Mining: Demonstrating Fair Use Project, which was generously supported by the Mellon Foundation.
False Discovery versus Familywise Error Rate Approaches to Outlier Detection
Creators: name: Yihuan Xu
name: Iglewicz, Boris
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Chemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Engineering

description: ABSTRACTOutliers, in general, are observations that deviate sufficiently from a base distribution. This study deals with outlier detection approaches for large samples from continuous univariate distributions. Investigated are the properties of a practical newer outlier detection approach based on use of a false discovery rate method in conjunction with a robustly estimated Tukey g-and-h base distribution. Compared are the properties of a boxplot type outlier detection approach that controls the familywise error rate with a newer false discovery rate approach. These options are compared in terms of error rates and effects of moving the outliers gradually further from base distribution center while using 5% and 1% false discovery rate or familywise error rates. Two microarray data sets are used as examples where the assumed null distributions do not fit the data well. In such cases the proposed estimated Tukey g-and-h null distribution approach leads to superior outlier detection performance.
Convective dissolution in porous media: three-dimensional imaging experiments and numerical simulations
Creators: name: Liyanage, Rebecca
Publisher: name: Imperial College London
Year: 2018

description: Convective dissolution is a phenomenon induced by a buoyant instability between two fluids resulting in characteristic finger-like mixing patterns. One important example is a key trapping mechanism during CO2 sequestration in deep saline aquifers. The Rayleigh number, Ra, which is a measure of convective vigour and the Sherwood number, Sh, which indicates the strength of mass transport are used to parameterise this process. We present a novel methodology to image convective dissolution using X-ray CT in a three-dimensional porous medium formed of glass beads with a model fluid pair MEG/water and BEG/water. 3D reconstructions allow us to visualise the spatial and temporal evolution of the plume from onset to the shutdown of convection while quantifying the macroscopic quantities such as the rate of dissolution and horizontal concentration profiles. We investigate convective dissolution with and without permeability heterogeneity over the Rayleigh range, Ra = 2000 - 5000, in a spherical, cuboidal and cylindrical geometry. Simple heterogeneity patterns such as single inclined layers and a series of discontinuous layers were included. It was concluded that the spatial configuration of the less permeable layers was the most important factor in either enhancing (due to flow focusing) or impeding (due to compartmentalisation of the plume) the rate of dissolution compared to the homogeneous case. However, linear trends in the Sherwood and Rayleigh numbers were consistency reported in both the homogeneous Sh = 0.025Ra and heterogeneous studies Sh = 0.0236Ra. 2D COMSOL numerical simulations were performed to extend the Ra range explored by the experiments and allow an investigation of permeability heterogeneity configurations not possible in the laboratory. The results confirmed the experimental findings with very similar scaling observed Sh = 0.022Ra. The results also shed light on the plume structures responsible for flow focusing. Finally, we present suggestions for future work in CO2-brine-rock systems.
Nigral iron and neuromelanin studies in Parkinson´s disease
Creators: name: Martin Bastida, Antonio
Publisher: name: Imperial College London
Year: 2018

description: Parkinson’s disease (PD) a neurodegenerative condition characterized by the reduction of the pigmented dopaminergic neurons of the substantia nigra pars compacta (SNc) and the loss of the dopaminergic striatal terminals which in turn result in the cardinal motor symptoms including bradykinesia, rigidity and tremor. Iron plays a deleterious role in the pathophysiology of PD due to the generation of reactive oxidative species that leads to oxidative stress and neurodegeneration. In addition neuromelanin is a complex pigment contained in the dopaminergic neurons of the SNc that plays a toxic role in pro-oxidative conditions such as PD. Magnetic resonance imaging (MRI) is a widely available nonionising technique allowing the study of structural properties of the SN such as iron deposition or neuromelanin pigmentation load in PD. In this thesis I have used state of the art neuroimaging to assess nigral iron accumulation and nigral depigmentation in PD, the correlation between neuromelanin decline and nigrostriatal terminal loss, and the potential clinical use of an iron chelation to improve clinical symptoms. The main findings of this thesis are as follows: A) Increased nigral iron accumulation in PD displays an ascendant stratification according to clinical severity at baseline and it is associated with bradykinesia and rigidity symptoms in cross-sectional and longitudinal settings. B) Nigral depigmentation in PD shows a descendant stratification according to disease duration at baseline and displays significant associations with motor severity at baseline and with bradykinesia at follow-up visits. C) The pattern of nigral pigmentation loss shows a ventro-medial pattern and there was a significant correlation between this loss and nigrostriatal terminals decline in the most affected side, but not in the least affected side. D) Finally, iron chelation with deferiprone in PD shows a trend of motor improvement after six months of treatment being optimally monitored with iron-sensitive MR imaging techniques. The results presented in this thesis support the application of multimodal imaging protocols to further understand the dopaminergic pathophysiology of PD and their usefulness for monitoring the progression of the disease.
The life of José María Morelos, the founder of the Mexican nation
Creators: name: Timmons, Wilbert H.
Publisher: name: The University of Texas at Austin
Year: 1949
Subjects: subject: Morelos, José María, 1765-1815
subject: Statesmen--Mexico--Biography
subject: Mexico--History--Wars of Independence, 1810-1821--Biography

description: Upon the advent of Morelos, the Mexican movement for independence passed into its second phase, and the period from the death of Hidalgo in 1811 to the death of Morelos in 1815 may be called, with full justification, the Epoch of Morelos. Not only was Morelos the greatest military commander produced by that period, but he was a statesman of a high order, who decreed far-reaching political, social, and economic reforms, and provided the revolutionary effort with a clearer enunciation of its principles and objectives. In addition to his outstanding military successes, Morelos was the first leader to declare for complete independence from Spain. Also, he was the inspiration for Mexico's first constitution, which prescribed a republican form of government based on a national representative system. His progressive social concepts envisaged the abolition of all caste distinctions and the substitution of the name "American" for all native-born, in whose interest the new government was to be shaped
Additional file 1 of Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
Creators: name: Gallagher, Hugh
name: Dumbleton, Jennifer
name: Maishman, Tom
name: Whitehead, Amy
name: Moore, Michael V.
name: Fuat, Ahmet
name: Fitzmaurice, David
name: Henderson, Robert A.
name: Lord, Joanne
name: Griffith, Kathryn E.
name: Stevens, Paul
name: Taal, Maarten W.
name: Stevenson, Diane
name: Fraser, Simon D.
name: Lown, Mark
name: Hawkey, Christopher J.
name: Roderick, Paul J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer

description: Additional file 1. WHO dataset.
Additional file 2 of Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
Creators: name: Gallagher, Hugh
name: Dumbleton, Jennifer
name: Maishman, Tom
name: Whitehead, Amy
name: Moore, Michael V.
name: Fuat, Ahmet
name: Fitzmaurice, David
name: Henderson, Robert A.
name: Lord, Joanne
name: Griffith, Kathryn E.
name: Stevens, Paul
name: Taal, Maarten W.
name: Stevenson, Diane
name: Fraser, Simon D.
name: Lown, Mark
name: Hawkey, Christopher J.
name: Roderick, Paul J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer

description: Additional file 2. Informed Consent Form.
PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage
Creators: name: Bailey, Laura J.
name: Bianchi, Julie
name: Hégarat, Nadia
name: Hochegger, Helfrid
name: Doherty, Aidan J.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: PrimPol is a recently identified member of the archaeo-eukaryote primase (AEP) family of primase-polymerases. It has been shown that this mitochondrial and nuclear localized enzyme plays roles in the maintenance of both unperturbed replication fork progression and in the bypass of lesions after DNA damage. Here, we utilized an avian (DT40) knockout cell line to further study the consequences of loss of PrimPol (PrimPol−/−) on the downstream maintenance of cells after UV damage. We report that PrimPol−/− cells are more sensitive to UV-C irradiation in colony survival assays than Pol η-deficient cells. Although this increased UV sensitivity is not evident in cell viability assays, we show that this discrepancy is due to an enhanced checkpoint arrest after UV-C damage in the absence of PrimPol. PrimPol−/− arrested cells become stalled in G2, where they are protected from UV-induced cell death. Despite lacking an enzyme required for the bypass and maintenance of replication fork progression in the presence of UV damage, we show that PrimPol−/− cells actually have an advantage in the presence of a Chk1 inhibitor due to their slow progression through S-phase.
Additional file 3 of Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
Creators: name: Gallagher, Hugh
name: Dumbleton, Jennifer
name: Maishman, Tom
name: Whitehead, Amy
name: Moore, Michael V.
name: Fuat, Ahmet
name: Fitzmaurice, David
name: Henderson, Robert A.
name: Lord, Joanne
name: Griffith, Kathryn E.
name: Stevens, Paul
name: Taal, Maarten W.
name: Stevenson, Diane
name: Fraser, Simon D.
name: Lown, Mark
name: Hawkey, Christopher J.
name: Roderick, Paul J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer

description: Additional file 3. Participant Information Sheet.
PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage
Creators: name: Bailey, Laura J.
name: Bianchi, Julie
name: Hégarat, Nadia
name: Hochegger, Helfrid
name: Doherty, Aidan J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: PrimPol is a recently identified member of the archaeo-eukaryote primase (AEP) family of primase-polymerases. It has been shown that this mitochondrial and nuclear localized enzyme plays roles in the maintenance of both unperturbed replication fork progression and in the bypass of lesions after DNA damage. Here, we utilized an avian (DT40) knockout cell line to further study the consequences of loss of PrimPol (PrimPol−/−) on the downstream maintenance of cells after UV damage. We report that PrimPol−/− cells are more sensitive to UV-C irradiation in colony survival assays than Pol η-deficient cells. Although this increased UV sensitivity is not evident in cell viability assays, we show that this discrepancy is due to an enhanced checkpoint arrest after UV-C damage in the absence of PrimPol. PrimPol−/− arrested cells become stalled in G2, where they are protected from UV-induced cell death. Despite lacking an enzyme required for the bypass and maintenance of replication fork progression in the presence of UV damage, we show that PrimPol−/− cells actually have an advantage in the presence of a Chk1 inhibitor due to their slow progression through S-phase.
Additional file 4 of Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease
Creators: name: Gallagher, Hugh
name: Dumbleton, Jennifer
name: Maishman, Tom
name: Whitehead, Amy
name: Moore, Michael V.
name: Fuat, Ahmet
name: Fitzmaurice, David
name: Henderson, Robert A.
name: Lord, Joanne
name: Griffith, Kathryn E.
name: Stevens, Paul
name: Taal, Maarten W.
name: Stevenson, Diane
name: Fraser, Simon D.
name: Lown, Mark
name: Hawkey, Christopher J.
name: Roderick, Paul J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Marine Biology
subject: Cancer

description: Additional file 4. Endpoint definitions.
Barriers and enablers to the implementation and sustainability of short-stay arthroplasty programs for elective primary total hip and knee replacement: A systematic review with qualitative evidence synthesis
Creators: name: Berkovic, D
name: Vallance, Patrick
name: Harris, IA
name: Naylor, JM
name: Lewis, PL
name: de Steiger, R
name: Buchbinder, R
name: Ademi, Z
name: Ackerman, IN
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 320216
subject: Orthopaedics
classificationCode: 420106
subject: Physiotherapy
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences
classificationCode: 42
subject: Health sciences

description: Introduction: We aimed to systematically review contemporary evidence on the barriers and enablers to implementing and sustaining short-stay arthroplasty programs for elective primary total hip and knee replacement from the perspectives of patients, health professionals, carers, healthcare administrators, funders and policymakers and to map the findings to the Theoretical Domains Framework (TDF). Methods: Medline, Cumulative Index to Nursing and Allied Health Literature, EMBASE, and the Cochrane Central Register of Controlled Trials were searched (up to 19 August 2023). Primary qualitative or mixed-methods studies reporting on perspectives relating to the review aims that utilised a short-stay programme were eligible for inclusion. Study quality was assessed using the qualitative critical appraisal tool from the Joanna Briggs Institute. Data were analysed inductively. The final themes were mapped to the TDF. The confidence in the findings was assessed using GRADE CERQual. Results: Fifteen studies were included. Twelve barrier themes and twelve enabler themes were identified. Three themes were graded with high confidence, 10 were graded with moderate confidence, three were graded with low confidence, and eight were graded with very low confidence. The most pertinent domains that the themes were mapped to for patients were beliefs about capabilities, reinforcement, and the environmental context and resources. Health professionals identified knowledge, environmental context and resources as important domains. Two domains were identified for carers: (1) social/professional role and identity and (2) memory, attention, and decision processes. Conclusion: We identified key barrier and enabler themes linked to the TDF that can be used to guide implementation initiatives and promote the sustainability of short-stay arthroplasty programs.
The amount of injected 177Lu-octreotate strongly influences biodistribution and dosimetry in C57BL/6N mice
Creators: name: Schüler, Emil
name: Österlund, Andreas
name: Forssell-Aronsson, Eva
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Background.177Lu-octreotate therapy has proven to give favorable results after treatment of patients with neuroendocrine tumors. Much focus has been on the binding and uptake of 177Lu-octreotate in tumor tissue, but biodistribution properties in normal tissues is still not fully understood, and the effect of receptor saturation may be important. The aim of this study was to investigate the influence of the amount of 177Lu-octreotate on the biodistribution of 177Lu-octreotate in normal tissues in mice. Material and methods. C57BL/6N female mice were intravenously injected with 0.1–150 MBq 177Lu-octreotate (0.039 μg peptide/MBq). The mice were killed 0.25 h to 14 days after injection by cardiac puncture under anesthesia. Activity concentration was determined in blood, bone marrow, kidneys, liver, lungs, pancreas, and spleen, and mean absorbed doses were calculated. Results. The activity concentration varied with time and amount of injected activity. At 4–8 h after injection, a local maximum in activity concentration was found for liver, lungs, pancreas, and spleen. With the exception for the lower injected activities (0.1–1 MBq), the overall highest uptake was found in the kidneys (%IA/g). Large variations were found and the activity concentration in kidneys was 11–23%IA/g at 4 h, and 0.22–1.9%IA/g at 7 days after injection. Furthermore, a clear reduction in activity concentration with increased injected activity was observed for lungs, pancreas and spleen. Conclusion. The activity concentration in all tissues investigated was strongly influenced by the amount of 177Lu-octreotate injected. Large differences in mean absorbed dose per unit injected activity were found between low (0.1–1 MBq, 0.0039–0.039 μg) and moderate amounts (5–45 MBq, 0.2–1.8 μg). Furthermore, the results clearly showed the need for better ways to estimate absorbed dose to bone marrow other than methods based on a single blood sample analysis. Since the absorbed dose to critical organs will limit the amount of 177Lu-octreotate administered, these findings must be taken into consideration when optimizing this type of therapy.
Linkage Isomerization in Nitrosothiols (RSNOs): The X-ray Crystal Structure of an S-nitrosocysteine and DFT Analysis of its Metastable MS1 and MS2 Isomers
Creators: name: Yi, Jun
name: Coppens, Philip
name: Powell, Douglas R.
name: Richter-Addo, George B.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Neuroscience
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Density functional theory calculations reveal that the previously unreported nitrosothiol MS1 and MS2 linkage isomers are metastable species with energies similar to those determined for other experimentally observed XNO linkage isomers. Nitrosation of protein cysteines to yield S-nitrosocysteine (cySNO) is an important component of nitric oxide biology. However, high-resolution structural data of cySNO in the absence of protein environment effects is lacking, as is information on cySNO linkage isomers. We report the ordered X-ray crystal structure of a cySNO compound. We employ density functional theory calculations to probe the ground-state and linkage isomers of cySNO, CH3SNO, and CF3SNO. The HOMO of CH3SNO contains an intramolecular CH···O interaction that helps rationalize the stability of the cis conformation; this interaction is absent in CF3SNO, which favors the trans conformation. We show that the isonitroso MS1 (RSON) and side-on MS2 (RS(η2-ON)) linkage isomers are metastable species, with MS1 and MS2 energies similar to those of other experimentally observed nitroso linkage isomers.
Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer
Creators: name: Rao, Shyam D.
name: Saleh, Ziad H.
name: Setton, Jeremy
name: Tam, Moses
name: McBride, Sean M.
name: Riaz, Nadeem
name: Deasy, Joseph O.
name: Lee, Nancy Y.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 60506 Virology

description: Background. To investigate the dose-volume factors in mastication muscles that are implicated as possible causes of trismus in patients following treatment with intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy for head and neck cancers. Material and methods. All evaluable patients treated at our institution between January 2004 and April 2009 with chemotherapy and IMRT for squamous cell cancers of the oropharynx, nasopharynx, hypopharynx or larynx were included in this analysis (N = 421). Trismus was assessed using CTCAE 4.0. Bi-lateral masseter, temporalis, lateral pterygoid and medial pterygoid muscles were delineated on axial computed tomography (CT) treatment planning images, and dose-volume parameters were extracted to investigate univariate and multimetric correlations. Results. Forty-six patients (10.9%) were observed to have chronic trismus of grade 1 or greater. From analysis of baseline patient characteristics, toxicity correlated with primary site and patient age. From dose-volume analysis, the steepest dose thresholds and highest correlations were seen for mean dose to ipsilateral masseter (Spearman's rank correlation coefficient Rs = 0.25) and medial pterygoid (Rs = 0.23) muscles. Lyman-Kutcher-Burman modeling showed highest correlations for the same muscles. The best correlation for multimetric logistic regression modeling was withV68Gy to the ipsilateral medial pterygoid (Rs = 0.29). Conclusion. Chemoradiation-induced trismus remains a problem particularly for patients with oropharyngeal carcinoma. Strong dose-volume correlations support the hypothesis that limiting dose to the ipsilateral masseter muscle and, in particular, the medial pterygoid muscle may reduce the likelihood of trismus.
Barriers and enablers to the implementation and sustainability of short-stay arthroplasty programs for elective primary total hip and knee replacement: A systematic review with qualitative evidence synthesis
Creators: name: Berkovic, D
name: Vallance, P
name: Harris, IA
name: Naylor, JM
name: Lewis, PL
name: de Steiger, R
name: Buchbinder, R
name: Ademi, Z
name: Ackerman, IN
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 320216
subject: Orthopaedics
classificationCode: 420106
subject: Physiotherapy
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences
classificationCode: 42
subject: Health sciences

description: Introduction: We aimed to systematically review contemporary evidence on the barriers and enablers to implementing and sustaining short-stay arthroplasty programs for elective primary total hip and knee replacement from the perspectives of patients, health professionals, carers, healthcare administrators, funders and policymakers and to map the findings to the Theoretical Domains Framework (TDF). Methods: Medline, Cumulative Index to Nursing and Allied Health Literature, EMBASE, and the Cochrane Central Register of Controlled Trials were searched (up to 19 August 2023). Primary qualitative or mixed-methods studies reporting on perspectives relating to the review aims that utilised a short-stay programme were eligible for inclusion. Study quality was assessed using the qualitative critical appraisal tool from the Joanna Briggs Institute. Data were analysed inductively. The final themes were mapped to the TDF. The confidence in the findings was assessed using GRADE CERQual. Results: Fifteen studies were included. Twelve barrier themes and twelve enabler themes were identified. Three themes were graded with high confidence, 10 were graded with moderate confidence, three were graded with low confidence, and eight were graded with very low confidence. The most pertinent domains that the themes were mapped to for patients were beliefs about capabilities, reinforcement, and the environmental context and resources. Health professionals identified knowledge, environmental context and resources as important domains. Two domains were identified for carers: (1) social/professional role and identity and (2) memory, attention, and decision processes. Conclusion: We identified key barrier and enabler themes linked to the TDF that can be used to guide implementation initiatives and promote the sustainability of short-stay arthroplasty programs.
Positive correlation between occlusion rate and nidus size of proton beam treated brain arteriovenous malformations (AVMs)
Creators: name: Blomquist, Erik
name: Ronne-Engström, Elisabeth
name: Ljubisa Borota
name: Gál, Gyula
name: Nilsson, Kristina
name: Lewén, Anders
name: Montelius, Anders
name: Grusell, Erik
name: Isacsson, Ulf
name: Enblad, Per
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background. Proton beam radiotherapy of arteriovenous malformations (AVM) in the brain has been performed in Uppsala since 1991. An earlier study based on the first 26 patients concluded that proton beam can be used for treating large and medium sized AVMs that were considered difficult to treat with photons due to the risk of side effects. In the present study we analyzed the result from treating the subsequent 65 patients. Material and methods. A retrospective review of the patients’ medical records, treatment protocols and radiological results was done. Information about gender, age, presenting symptoms, clinical course, the size of AVM nidus and rate of occlusion was collected. Outcome parameters were the occlusion of the AVM, clinical outcome and side effects. Results. The rate of total occlusion was overall 68%. For target volume 0–2cm3 it was 77%, for 3–10 cm3 80%, for 11–15 cm3 50% and for 16–51 cm3 20%. Those with total regress of the AVM had significantly smaller target volumes (p < 0.009) higher fraction dose (p < 0.001) as well as total dose (p < 0.004) compared to the rest. The target volume was an independent predictor of total occlusion (p = 0.03). There was no difference between those with and without total occlusion regarding mean age, gender distribution or symptoms at diagnosis. Forty-one patients developed a mild radiation-induced brain edema and this was more common in those that had total occlusion of the AVM. Two patients had brain hemorrhages after treatment. One of these had no effect and the other only partial occlusion from proton beams. Two thirds of those presenting with seizures reported an improved seizure situation after treatment. Conclusion. Our observations agree with earlier results and show that proton beam irradiation is a treatment alternative for brain AVMs since it has a high occlusion rate even in larger AVMs.