cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cell-free DNA methylation as a noninvasive biomarker for residual lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer-related deaths globally. Most patients are diagnosed at a late stage when a cure is very unlikely. Additionally, a significant proportion of early-stage patients recur despite curative intent therapy. One important unmet need is the lack of sensitive methods for monitoring cancer patients after treatment. Currently, computed tomography is the main tool used for monitoring. Unfortunately, imaging methods are limited to macroscopic lesions and miss microscopic re-emerging tumors. Therefore, additional tools at the molecular level are needed to detect tumor recurrence early. Our lab is a pioneer in the field of liquid biopsies, which utilize a simple blood draw for the detection and monitoring of cancer. Liquid biopsies leverage the fact that both healthy and malignant cells in the body release some of their DNA into the bloodstream as they die and turn over. This leads to a small subset of DNA molecules deriving from cancer cells, that can be used for detection and monitoring at the molecular level. Cell-free DNA (cfDNA) is the main type of molecular biomarker that is used in liquid biopsies. The cancer-derived molecules are known as circulating tumor DNA (ctDNA), and in most studies, cancer-specific mutations, or alterations of the DNA sequence, are used to identify the ctDNA molecules from the background. However, this approach fails for patients in which mutations cannot be identified. Other significant limitations include low DNA yields acquired from a patient’s blood sample and lack of available tumor tissue. Here, I propose to apply a liquid biopsy method that characterizes a molecule based on distinct modifications to DNA bases, namely methylation. Methylation modifications are used by the cell to change the meaning of the genetic code without introducing mutations. I hypothesize that methylation changes cfDNA will more sensitively represent the molecules’ origin than genetic changes alone. I will for the first time apply this method for detecting residual disease in lung cancer after curative intent therapy. The completion of this project will have significant contributions not only in the clinical tools available for monitoring but could also result in improved survival outcomes for patients suffering from this horrible disease.
Uktena Fend, Rodriguez & Lenat, 2015, n. gen.
Creators: name: Fend, Steven V.
name: Rodriguez, Pilar
name: Lenat, David R.
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Lumbriculida
Lumbriculidae
Uktena

description: Uktena n. gen.
Included species: Uktena riparia n. sp. (type species by monotypy)
Diagnosis (autapomorphies are underlined). Medium-sized to large worms with long, superficially-ringed proboscis. Chaetae simple-pointed. Reproductively-mature worms have several modified chaetae in ventral chaetal bundles of two postatrial segments. Two pairs of lateral blood vessels in posterior segments, with many blind branches. Nephridia begin on 10/11. One pair of testes in VIII, one pair of ovaries in IX. Male pores paired on VIII, in deep copulatory bursae with associated glands. Prosoporous atria elongate-cylindrical, ampulla covered with clusters of prostatic cells; ectal ducts produce tubular spermatophores. One pair of sperm funnels, extending back one or more segments in sperm sac. Vasa deferentia do not penetrate posterior septum (8/9). Female pores on posterior septum of first post-atrial segment. Spermathecae paired in atrial segment, anterior to atria; spermathecal pores within deep bursae containing a glandular, protrusible, copulatory organ for spermatophore attachment.
Remarks. Uktena n. gen. has three distinctive autapomorphies, all of which were previously unknown in the family Lumbriculidae: a unique arrangement of genital chaetae, a “copulatory organ” within a large, muscular spermathecal bursa, and tubular spermatophores (see Discussion). The presence of spermathecae in the atrial segment is unusual within the family, but this character is shared with at least three other lumbriculid genera, as well as two species of Dorydrilus Piguet, 1913 (see Discussion). The combination of a prosoporous atrium and spermathecae in the male segment suggests that Uktena is closely related to Kincaidiana Altman, 1936, also a large worm with a filiform proboscis. However, Kincaidiana has the male pores in IX (instead of VIII) and has spermathecae also in postatrial segments. Guestphalinus Michaelsen, 1933 and Cookidrilus Rodriguez & Giani, 1987 are differentiated from Uktena and Kincaidiana by their semiprosoporous male ducts, as well as by the position of atria in IX and X, respectively. The three Cookidrilus species are small worms, without a proboscis, and with spermathecae also in post-atrial segments (Rodriguez & Giani 1987, Route et al. 2004, Rodriguez et al. 2014).
description: Published as part of Fend, Steven V., Rodriguez, Pilar & Lenat, David R., 2015, Uktena riparia n. gen., n. sp. (Annelida, Clitellata, Lumbriculidae), a new spermatophore-producing oligochaete, pp. 411-424 in Zootaxa 3994 (3) on pages 412-413, DOI: 10.11646/zootaxa.3994.3.5, http://zenodo.org/record/246106
Stakeholder engagement report: Utilities
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 2013

description: The New Jersey Climate Adaptation Alliance (NJCAA) is involved in development of a set of state and local public policy recommendations to enhance climate change preparedness and capacity in New Jersey. The NJCAA has solicited input from stakeholders in the investor-owned utility, telecommunications, and cabletelevision sectors as to perceptions of climate change impacts to their businesses and anystate and local policy changes they would recommend to allow the sectors to better preparefor and respond to a changing climate. Investor-owned utilities hold a unique place as “natural monopolies” and differ substantially from other business sectors. Questionnaires were developed for the water/wastewater,electric, gas, and telecommunications sectors. The report discusses: perception of climate change in the utility sector; climate change impacts of concern; sectoral perceptions of preparedness; leading practices; challenges;  and recommendations.
Alysicarpus vaginalis
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Alysicarpus
Alysicarpus vaginalis

description: 3.4 Alysicarpus vaginalis (L.) DC., Prodr. 2: 353. 1825.
(Fig. 3A)
Ervas, ca. 20 cm alt.; ramos glabrescentes a puberulentos, inermes. Estípulas ca. 5,7 × 1,4 mm, triangulares, livres, persistentes.Folhas 1-folioladas; pecíolos ca. 9,7 mm compr., glabros a puberulentos; folíolos 8-15 × 7-12 mm, elípticos a circulares, base retusa, ápice arredondado, margem inteira, faces adaxial e abaxial esparso-puberulentas; nectários foliares ausentes. Inflorescências racemosas, ca. 20-floras, terminais. Flores não observadas. Lomentos 5-6 artículos, ca. 1,9 × 0,2 cm, glabros, indeiscentes. Sementes 1 por artículo, reniformes, 1,7 × 1 mm, beges.
Espécie com distribuição original no Velho Mundo (Pedley 2001) e introduzida no Novo Mundo (Torres-Colin et al. 2011). No Brasil ocorre nas regiões Norte (TO), Nordeste (PI), Centro-Oeste (GO, MS, MT), Sudeste (SP) e Sul (PR), habitando os Domínios Fitogeográficos do Cerrado e Pantanal (BFG 2015, material suplementar). No PNMJ ocorre em Manguezal Degradado e Área Antropizada. Coletada com flores e frutos em março.
As características exclusivas desta espécie são as estípulas beges, paleáceas e bem desenvolvidas e os frutos articulados do tipo lomento. Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL, ESPÍRITO SANTO, Vila Velha, Parque Natural Municipal de Jacarenema, 01.III.2012, L. A. Silva 354 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 278, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Does the co-use of tobacco and cannabis increase the risk of earlier age at menopause?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is strongly linked to earlier age at menopause, which can have a profound impact on women’s health and well-being. While women in the US typically reach menopause around age 51, smokers may reach menopause 1-2 years earlier on average and have double the risk for early (between age 40-45) and premature (before age 40) menopause as non-smokers. Earlier age at menopause, particularly early and premature menopause, can lead to unexpected fertility loss as well as increased risk for premature death, early myocardial infarction, cardiovascular disease, neurologic disease, osteoporosis, psychosexual dysfunction, and depression. Age at menopause is thought to be influenced by tobacco use through exposure to chemicals called polycyclic aromatic hydrocarbons. These chemicals are also released by smoking cannabis, and studies suggest that co-use of tobacco and cannabis leads to far higher exposures than tobacco use alone. Cannabis use may therefore add to the known effect of tobacco use on age at menopause, putting women who co-use tobacco and cannabis at even higher risk for premature, early, and earlier age at menopause and related harms. Importantly, cannabis use and co-use is increasing among women, and women who use cannabis may be subject to particularly high rates of polycyclic aromatic hydrocarbon exposure for two reasons: 1) women often report cannabis use to manage insomnia, anxiety, and/or chronic pain, resulting in frequent use to manage these common chronic conditions; 2) over 70% of adult cannabis users also use tobacco, and women are more likely to co-use cannabis and tobacco than use cannabis alone. Identifying whether cannabis use and tobacco and cannabis co-use puts women at higher risk for premature, early, or earlier age at menopause has profound public health importance for early recognition and appropriate counseling in the health care setting. However, these relationships have not been examined to date. In order to address this key evidence gap affecting women’s health and health care, I propose to construct a nationally representative sample of women aged 45-64 using Ipsos KnowledgePanel. This study will build on my team’s experience leveraging this resource to address detailed questions about tobacco and cannabis use as well as my expertise in women’s health related to menopause.
Andrena (Chlorandrena) astica Warncke 1967
Creators: name: Wood, Thomas J.
name: Ismael, Halgurd R.
name: Baiocchi, Daniele
name: Hamad, Mudhafar I.
name: Bapir, Tahseen T.
name: Selis, Marco
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Andrenidae
Andrena
Andrena astica

description: 8.Andrena(Chlorandrena)asticaWarncke, 1967 *
Material examined.
Iraq: Duhok, Mt. Gara [S of Sarsing], 37.0158 ° N, 43.3506 ° E, 1912 m, 11. v. 2023, 3 ♂, leg. D. Baiocchi, MSVI / TJWC; Lebanon: Bekaa, Qob Elias valley, 33.7989 ° N, 35.8192 ° E, 900 m, 5. iv. 2023, 1 ♂, leg. M. Boustani, TJWC.
Distribution.
Greece, Turkey, Cyprus, Israel and West Bank, Lebanon *, Georgia, Iraq *, Iran (Schwenninger 2015; Wood and Monfared 2022).
description: Published as part of Wood, Thomas J., Ismael, Halgurd R., Baiocchi, Daniele, Hamad, Mudhafar I., Bapir, Tahseen T. & Selis, Marco, 2024, A first revision of the Andrena of Iraq (Hymenoptera, Andrenidae), with the description of two new species from Iraqi Kurdistan and additional records from surrounding countries, pp. 267-298 in ZooKeys 1205 on pages 267-298, DOI: 10.3897/zookeys.1205.120033
RCA Laboratories
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1957

description: Radio Corporation of America (RCA) was an American electronics company in existence from 1919 to 1986.  The booklet entitled “The RCA Laboratories” was prepared by RCA’s Laboratories Division to show the special facilities and physical conditions which went into making up the seat of RCA research at the David Sarnoff Research Center located in Princeton, New Jersey.  Within the booklet, RCA’s Laboratories Division present their ideas of what a research laboratory should be, not only in its physical construction, but also in the facilities which it affords for individual service and for group communication and interaction.  Two historic technology developments, among many, took place at the David Sarnoff Research Center and have been recognized by the IEEE History Center Milestone Program.  The first is the innovation of the Monochrome-Compatible Electronic Color Television that took place between 1946 and 1950.  For the next three years, engineers at the RCA Laboratories worked with other industry engineers to develop a national analog standard that lasted until the transition to digital broadcasting at the turn of the century.  The second historic innovation that took place at the David Sarnoff Research Center is the invention of the Liquid Crystal Display (LCD) in 1968.  The innovation of LCDs launched a global industry that now produces millions of LCD panels annually for watches, calculators, flat-panel displays in televisions, computers, cell phones, tablets and other electronics.
Ancistrotropis peduncularis A. Delgado, Amer. J. Bot.
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Ancistrotropis
Ancistrotropis peduncularis

description: 3.5 Ancistrotropis peduncularis (Fawc. & Rendle) A. Delgado, Amer. J. Bot. 98(10): 1704. 2011.
(Fig. 3N)
Trepadeiras; ramos glabros, sulcados, inermes. Estípulas 2-3 × 1-2 mm, triangulares, livres, persistentes; Folhas imparipinadas, 3-folioladas; Pecíolos ca. 40 mm compr., pubescentes; raque foliar ca. 11 mm compr., esparsamente puberulenta; folíolos 35-45 × 30-45 mm, deltados, base oblíqua, cuneada ou truncada, ápice agudo, margem inteira, faces adaxial e abaxial glabras; nectário foliar ausente. Inflorescência racemo, ca. 4-10-floras, terminal. Flores papilionadas, assimétricas, pentâmeras, não ressupinadas; cálice gamossépalo, ca. 5 × 4 mm, campanulado, verde, glabro; corola dialipétala, lilás, ca. 13 × 10 mm, vexilo ca. 12 × 11 mm, alas ca. 15 × 5 mm, carenas ca. 16 × 5 mm, espiraladas; estames 10, diadelfos, 16-18 mm compr., homodínamos, tubo estaminal 15-17 mm compr.; anteras uniformes, 1 mm compr., rimosas; estaminódios ausentes; ovário 6-7 mm compr., séssil; estilete 9 mm compr., puberulento. Legumes 85-95 × 5 mm, glabros, deiscentes. Sementes 5; 3 × 2 mm, reniformes a circular, marrons.
Ocorre da América Central ao norte da Argentina (Maréchal et al. 1978). No Brasil ocorre nas regiões Norte (AM, PA, RO), Nordeste (BA), Centro-Oeste (DF, GO, MS, MT), Sudeste (MG, SP) e Sul (PR, RS), nos seguintes Domínios Fitogeográficos: Amazônia, Caatinga, Cerrado, Mata Atlântica, Pantanal (BFG 2015, material suplementar). No PNMJ ocorre na fisionomia Arbustiva Fechada Não Inundável. Coletada com flores e frutos em abril.
Junto com Macroptilium lathyroides (L.) Urb., distinguem-se das demais espécies de trepadeiras do PNMJ por possuirem as pétalas da carena lateralmente torcidas. Diferencia-se de M. lathyroides pelo formato dos folíolos (deltados em A. peduncularis vs. elípticos em M. lathyroides), comprimento do pecíolo (ca. 40 mm em A. peduncularis vs. 25-30 mm em M. lathyroides) e cor da corola (lilás em A. peduncularis vs. vinácea em M. lathyroides). O gênero Ancistrotropis é caracterizado pelas carenas curvadas em formato de gancho (Delgado-Salinas et al. 2011). Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL, ESPÍRITO SANTO, Vila Velha, Parque Natural Municipal de Jacarenema, 20.IV.2011, L. A. Silva 01 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 278, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Andira fraxinifolia Benth., Comm. Legum. Gen.
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Andira
Andira fraxinifolia

description: 3.6 Andira fraxinifolia Benth., Comm. Legum. Gen.: 44. 1837.
Arbustos ca. 2,5 m alt.; ramos sulcados, puberulentos, inermes. Estípulas 0,9 × 0,6 mm, triangulares, livres, decíduas. Folhas imparipinadas, 7-9-folioladas; pecíolos 20-40 mm compr., glabrescentes; raque foliar 40-70 mm compr., glabra; folíolos 30-55 × 13-20 mm, elípticos a estreitamente elípticos, base arredondada a aguda, ápice acuminado a cuspidado, margem inteira, faces adaxial e abaxial glabras; nectários foliares ausentes. Inflorescências e flores não observadas. Drupas 4,5-5 × 3-3,5 cm, glabras, indeiscentes. Sementes 1, elípticas, 28-35 × 25-30 mm, castanhas a alaranjadas.
Espécie endêmica do Brasil, ocorrendo nas regiões Nordeste (AL, BA, CE, PB, PE, RN, SE), Centro-Oeste (DF, GO), Sudeste (ES, MG, RJ, SP) e Sul (PR, RS, SC) (Pennington 2003; BFG 2015, material suplementar). Habita a Caatinga, Cerrado, Mata Atlântica, Restinga, Mata Atlântica, Campo Rupestre e Áreas em Regeneração (Pennington 2003; BFG 2015, material suplementar). No PNMJ ocorre na formaçãoArbustivaAberta Não Inundável. Coletada com frutos em maio e de agosto a outubro.
Diferencia-se das demais espécies do PNMJ pelo fruto do tipo drupa. Distingue-se de Andira nitida, espécie simpátrica no Parque, por possuir folhas 7-9-folioladas (vs. 5-7 folíolos em A. nitida), folíolos menores (30-55 × 13-20 mm vs. 50-80 × 35- 20 mm) e frutos maiores (4,5-5 × 3-3,5 cm vs. 2-4 × 1,9-2,8 cm).
Material examinado: BRASIL, ESPÍRITO SANTO, Vila Velha, Parque Natural Municipal de Jacarenema: 17.IX.2010, B. Z. Rohor 05 (VIES); 03. V.2011, L. A. Silva 010 (VIES); 01.X.2010, L. A. Silva et al. 86 (VIES); 14.VIII.2013, L. A. Silva 373 (VIES).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on pages 278-279, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Understanding Racial Disparities in Head and Neck Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Head and neck cancer is an important cause of cancer death in the United States. Tobacco use is the primary risk factor for head and neck cancer. Racial/ethnic minorities (especially Black patients) have worse survival outcomes than non-Hispanic White patients, even after accounting for severity of disease. Some of the racial/ethnic differences in survival may be explained by differential access to high-quality care. Several studies have shown that racial/ethnic minorities are more likely than non-Hispanic Whites to be treated in low-quality hospitals. However, previous studies used surrogates instead of actual measures of hospital quality. Insurance status is another factor that affects quality of care and survival. This project will evaluate the role of insurance status, hospital quality and quality of care as drivers of racial/ethnic disparities in head and neck cancer survival. We will examine: (1) whether insurance status is associated with treatment in high-quality hospitals and receipt of guideline-compliant care; 2) whether race/ethnicity is associated with treatment in high-quality hospitals and receipt of guideline-compliant care; and (3) whether insurance status and hospital quality mediate racial/ethnic disparities in head and neck cancer survival. We will use data the California Cancer Registry (a state-wide database of cancers in California), and discharge records and hospital characteristics from the California Office of Statewide Health Planning and Development. The knowledge gained from this study will improve our understanding of factors contributing to the persistent racial differences in cancer outcomes. The findings will provide valuable information that will help in the design of interventions aimed at addressing disparities in tobacco-related cancer outcomes.
Andira nitida Mart. ex Benth., Comm. Legum. Gen.
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Andira
Andira nitida

description: 3.7 Andira nitida Mart. ex Benth., Comm. Legum. Gen.: 45. 1837.
(Fig. 5L)
Arbustos, 1-2,5 m alt.; ramos, glabros, inermes. Estípulas ca. 4 × 1 mm, triangulares, livres, decíduas. Folhas imparipinadas, 5-7 folioladas; pecíolos 25-40 mm compr., glabros; raque foliar 60-70 mm, glabra; folíolos 50-80 × 35- 20 mm, lanceolados, base arredondada, ápice agudo, margem inteira, faces abaxial e adaxial glabras; nectários foliares ausentes. Inflorescências paniculadas, 80-120-floras, terminais. Flores papilionadas, pentâmeras, não ressupinadas; cálice gamossépalo, ca. 4-6 × 4-5 mm, campanulado, roxo, glabro; corola dialipétala; lilás, vexilo ca. 10 × 10 mm, alas ca. 12 × 4 mm, carenas ca. 10 × 3,5 mm, não espiraladas; estames 10, diadelfos, ca. 11 mm compr., heterodínamos; anteras uniformes, ca. 0,7 mm compr., rimosas; estaminódios ausentes; ovário ca. 5 mm compr., séssil, glabro; estilete ca. 3,5 mm compr., pubescente. Drupas 2-4 × 1,9-2,8 cm, glabras, indeiscentes. Sementes 1, esféricas, 15 × 35 mm compr., castanhas.
Espécie de distribuição restrita ao Brasil ocorrendo nas regiões Nordeste (AL, BA, PE, SE) e Sudeste (ES, RJ), no Domínio Fitogeográfico Mata Atlântica (BFG 2015, material suplementar). No PNMJ ocorre na formação Arbustiva Aberta Não Inundável. Coletada com flores em abril e maio e frutos em abril, maio e outubro.
Assemelha-se à A. fraxinifolia, pelo fruto do tipo drupa. Os caracteres que diferenciam estas espécies foram discutidos anteriormente.
Material examinado: BRASIL, ESPÍRITO SANTO, Vila Velha, Parque Natural Municipal de Jacarenema, 21.V.2011, L. A. Silva 014 (VIES); 21.V.2011, L. A. Silva 017 (VIES); 21. V.2011, L. A. Silva 019 (VIES); 01.IV.2012, L. A. Silva & P. H.D. Barros 206 (VIES); 01.IV.2012, L. A. Silva & P. H.D. Barros 209 (VIES);
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 279, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
Charting Paths to Prevention for Breast Cancer: Building Community Partnerships for Action
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: CLASP-BC aims to advance primary prevention of breast cancer by developing research teams to implement and evaluate high-impact, population-based primary prevention interventions focused on California’s culturally, ethnically, and racially diverse and medically underserved communities.

 Charting Paths to Prevention for Breast Cancer seeks to identify intervention priorities shared by diverse California stakeholders (community leaders, academics, practitioners, and policy experts) and build cross-disciplinary teams to pursue prevention research.

 Stakeholders from across the state will prioritize policy interventions recommended in the CBCRP-sponsored Paths to Prevention: the California Breast Cancer Primary Prevention Plan; develop collaborations and form cross-disciplinary teams to implement and evaluate community-based interventions; and provide training in Community-Partnered Participatory Research to help teams compete for Phase 2 funding.

 Recruited participants will include strong representation of culturally, ethnically, and racially diverse and medically underserved communities. Through the process of Concept Mapping, evidence-informed policy interventions will be drawn from Paths to Prevention and presented to participants to sort for commonalities and rated based on values such as feasibility and impact. Data will be analyzed to identify high priority issues and common interests across stakeholders.

 Regional meetings will disseminate and gather feedback on the Concept Mapping results, spark interest in potential research projects, and foster cross-stakeholder teams. Proposed projects will implement and evaluate multi-jurisdictional systemic interventions to reduce breast cancer risk, while ensuring these interventions are relevant to, embraced by, and developed in full partnership with California’s diverse communities. These cross-disciplinary teams will be invited to a CBCRP-led CPPR/D&I training to prepare them to apply for Phase 2 grants.

 The groundbreaking Paths to Prevention, released in 2020, identified systemic primary prevention strategies for breast cancer. CLASP-BC seeks to make those strategies a reality. BCPP’s continued commitment to a population-level approach, with a racial and social justice lens, will lead to primary prevention interventions that center the priorities and leadership of disproportionately impacted communities.
The PARQuit Smoking Cessation intervention for adults with serious mental illness
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Adults with serious mental illness (SMI) have higher rates of physical illnesses and face earlier deaths than the general population. Estimates suggest that the majority of adults with SMI smoke cigarettes. Cigarette smoking worsens acute and chronic illnesses, including cancer, experienced by many adults with SMI. Even though the motivation to quit smoking is high, their quit rates are poor. Modifiable reasons for the high rates of smoking include: lack of access to state-of-the art tobacco cessation treatment, misconceptions among patients and providers that tobacco use decreases psychiatric symptoms, and mental health treatment settings that are not tobacco-free.

 Combining treatments that help with the multi-level experience of quitting smoking, such as cessation concerns (e.g., irritability and cravings), indicate strategies to promote overall health (e.g., exercise) is a promising approach. Our team has found that a game-based group physical activity program is an accessible and effective method to improve psychiatric symptoms, increase physical activity, decrease social isolation, and improve health among people with SMI.

 We propose to test the effect of a combination treatment to improve smoking cessation. We previously developed the Parks and Recreation Quit (“PARQuit”) program, which involves the following critical aspects of smoking cessation: a) game-based group physical activity intervention (50 minutes, 3X/week for 12 weeks), b) nicotine replacement therapy (NRT), and c) smoking cessation counseling. This program will address an urgent need to identify interventions that assist smoking cessation efforts, while contributing to improved health for people with SMI. In this proposed study in a sample of 100 adults with SMI, we will: 1) Examine the impact of the 3 component PARQuit intervention on smoking cessation compared to a control condition (sedentary games, NRT, and cessation counseling) among adults with SMI; 2) Examine the impact of the 3 component PARQuit intervention on psychiatric symptoms compared to a control condition among adults with SMI; 3) Determine whether level of physical activity mediates the relationship between the physical activity component of PARQuit intervention and smoking cessation.
Additional file 1: Figure S1. of Application of a library of near isogenic lines to understand context dependent expression of QTL for grain yield and adaptive traits in bread wheat
Creators: name: FarrĂŠ, Alba
name: Sayers, Liz
name: Leverington-Waite, Michelle
name: Goram, Richard
name: Orford, Simon
name: Wingen, Luzie
name: Mumford, Cathy
name: Griffiths, Simon
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Means of minimum (blue line) and maximum (red line) temperatures and cumulated rainfall (blue bars) during the months of the growth cycle for both trials. (PDF 95Â kb)
The study of wall interactions of spin polarized rubidium atoms using the frequency shift in the electron paramagnetic resonance of the rubidium atoms
Creators: name: Ulanski, Emily Joy
Publisher: name: No Publisher Supplied
Year: 2014

description: I studied the effect of wall collisions on the electron paramagnetic resonance (EPR) of gas phase alkali metal atoms (8&Rb). Two types of walls were studied: antirelaxation-coated walls and RbH-coated walls. I measured the dwell times of spin polarized Rb atoms on the two most common antirelaxation coatings, octadecyltrichlorosilane (OTS)- and paraffin. I found that at a cell temperature of &2 C the dwell times for  OTS- and paraffin-coated walls are 0.9 ± 0.1 μs and 1.8 ± 0.2 μs, respectively. The implication of these dwell times, which are much longer than what was previously reported in the literature, is discussed in connection with the relaxing property of these coatings. In cells coated with RbH salt I made the first observation of the EPR frequency shift of the gas phase 8&Rb atoms. Due to collisions with the RbH  salt, which was nuclear spin polarized by spin exchange with optically pumped Rb vapor. The measured EPR frequency shifts are of the order of several hundred Hz in a millimeter-sized cell. By measuring the dependence of the EPR frequency shifts on cell length and by comparing the EPR frequency shifts in RbH-coated cells with those in OTS-coated cells, I provided convincing evidence that the observed EPR  frequency shifts are due to collisions with RbH-coated walls, and not due to gas phase processes. The EPR frequency shift is due to the Fermi contact interaction between the s-electron of the adsorbed 8&Rb atom and the polarized nucleus on the salt surface. The measured EPR frequency shifts allowed me to calculate the ensemble-averaged phase shift  experienced by the Rb atom while adsorbed on the walls. Under our experimental condition   this is about &0 mrad. My experiment opens up the possibility  of studying surface NMR using gas phase EPR. The phase shift is proportional to the surface nuclear polarization, thus provides an interesting method for measuring the surface nuclear polarization using gas phase EPR. My observation will alert the high precision miniature atomic magnetometry community that collisions with cell walls may cause a systematic error and line broadening in the magnetic resonance frequency.
Understanding Pancreatic Ductal Adenocarcinoma Evolution from Different Cells of Origin
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic cancer is projected to be the second leading cause of cancer deaths in the U.S. by 2026. This cancer is associated with a dismal survival rate, with <10% of patients surviving 5 years after diagnosis, and is attributable to detection of pancreatic cancer only at very late stages, when it has metastasized, and to the inefficacy of current therapies. Early detection of pancreatic cancer is therefore a critical goal, but it remains challenging in part because the early steps of pancreatic cancer initiation remain poorly understood. One of the most important risk factors is tobacco smoking, estimated to cause 25% of pancreatic cancers. Of note, tobacco-related genetic signatures in pancreas are distinct from those observed in the lung, indicating that findings on lung may not translate to tissues not directly exposed to tobacco smoke. The impact of tobacco in pancreas cancer should thus be studied in the pancreas specifically.
 There are two major cell types in the pancreas, acinar and ductal cells. These belong to the exocrine compartment of the pancreas, which is involved in producing enzymes to digest food. Using mouse models, we have investigated the origins of pancreatic cancer by asking which of these cell types is altered to lead to pancreatic cancer. Interestingly, we found that pancreatic cancer can originate from either cell type and that cancers arising from these two cell types resemble distinct subtypes of human pancreatic cancer with different prognoses. Moreover, the morphological stages of acinar or ductal cell-derived cancers are visually different, suggesting distinct paths of tumor evolution. These findings highlight the importance of better understanding early events of pancreas cancer development as they determine cancer subtypes and subsequently clinical outcomes. My goal is to understand the molecular details of how pancreatic cancer arises from these two critical cell types and to characterize the distinct paths of tumor evolution. Insights into the early events of pancreas cancer development may hint at how tobacco promotes cancer in tissues affected by tobacco without being directly exposed to smoke. Overall, my work will help address a significant unmet need in this deadly disease, laying the path for developing early detection strategies and identifying therapies for both acinar and ductal cell derived cancers.
Cimex furnarii Cordero & Vogelsang 1928, comb. nov.
Creators: name: Di, Osvaldo R.
name: Turienzo, Paola N.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cimicidae
Cimex
Cimex furnarii

description: Acanthocrios furnarii (Cordero & Vogelsang, 1928) comb. nov.
Cimex furnarii Cordero & Vogelsang 1928: 671 –673 [descr.; distr.; figs.]; Del Ponte & Riesel 1945: 473 [distr.; hosts]; Lent & Ábalos 1946: 347 [anat.].
Cimex passerinus Cordero & Vogelsang 1928: 674 –676 [descr.; distr.; figs.]; Usinger 1966: 468 –469 [refs.], 471 [syn.].
Ornithocoris furnarii: Romaña & Ábalos 1947: 80 [distr.; hosts]; Wygodzinsky 1951: 187 [key nymphs I], 195–196 [distr.; biol.], figs. 7–9, 47–50; Wygodzinsky 1959a: 529 [distr.]; Wygodzinsky 1959b: 485 –486 [hosts]; Hicks 1959: 248 [refs.; host], 447–448 [host; refs.]; Ronderos 1961: 33 [map], 34–35 [distr.]; Sakamoto et al. 2006: 3162 [table], 3166 [table].
Caminicimex furnarii: Usinger 1966: 468 –471 [comb. nov.; descr.; distr.; hosts]; Hicks 1971: 167 [refs.; host], 255 [host; refs.]; Andrade Figueiredo 1995: 23 [distr.; host]; Aramburú & Carpintero 2006: 85 [distr.; hosts]; Turienzo & Di Iorio 2007 [distr.; refs.; hosts]; Carpintero & Aramburú 2007: 153 –156 [distr.; hosts].
Acanthocrios furnarii has always been associated with the “hornero” [Furnarius rufus (Gmelin, 1788)] in Argentina and Uruguay (Turienzo & Di Iorio 2007), but recently the bug was found in nests of Hirundo rustica [erythrogaster Boddaert, 1789], Progne chalybea [domestica (Vieillot, 1817)] (Aramburú & Carpintero 2006) and also Progne elegans Baird, 1865 [Aves: Hirundinidae] from Buenos Aires (Carpintero & Aramburú 2007). Swallows are probably the primary hosts of Acanthocrios furnarii, and the bugs’ presence in such other nests as those of Furnarius rufus and A. annumbi, is probably due to nest parasitism by bird species (Turienzo & Di Iorio 2007). Cimicidae are known to remain for a long time in swallows´nests, and can go without feeding for prolonged periods when swallows abandon some nesting sites; sometimes during these times engorged bugs have been found with other animals that used the cliff swallow nests (Loye 1985). It is not known if A. furnarii can survive and form large colonies in the nests of birds other than swallows (Table 1).
description: Published as part of Di, Osvaldo R. & Turienzo, Paola N., 2008, A nomenclatural note in Cimicidae (Hemiptera) from South America, pp. 65-68 in Zootaxa 1730 on page 66, DOI: 10.5281/zenodo.181295
Treatment for food allergy
Creators: name: Sampson, Hugh A.
name: Plaut, Marshall
name: Akdis, Cezmi A.
name: Lack, Gideon
name: Burks, A. Wesley
Publisher: name: Elsevier
Year: 2018

description:
The prevalence of IgE-mediated food allergy is an increasing public health concern effecting millions of persons worldwide. The current standard of treatment is strict avoidance of the offending food or foods, and to date, there are no regulatory approved treatments for food allergy. A significant amount of research has been directed at various forms of food immunotherapy, including oral, sublingual, and epicutaneous delivery routes. Although oral immunotherapy has shown the greatest promise for efficacy in terms of the amount of protein that can be ingested, it has also demonstrated less tolerability and a less favorable safety profile compared with sublingual immunotherapy and epicutaneous immunotherapy, which offers the least protection but has the best safety and tolerability profile. Studies have been conducted with adding adjuvants and anti-IgE to enhance either the efficacy or safety of food immunotherapy. Multiple concepts of food immunotherapy beyond these first-generation treatments are in either animal or early phase 1 studies.
Canavalia parviflora Benth., Fl. Bras.
Creators: name: Silva, Lucas
name: Thomaz, Luciana Dias
name: Dutra, Valquíria Ferreira
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Canavalia
Canavalia parviflora

description: 3.8 Canavalia parviflora Benth., Fl. Bras. 15(1): 177. 1862.
(Fig. 4A)
Trepadeiras; ramos glabros, inermes. Estípulas não observadas, decíduas. Folhas imparipinadas, 3-folioladas; pecíolos ca. 30 mm compr., glabros; raque foliar 7-8 mm compr., glabra; folíolos 47-67 × 32-39 mm, elípticos, base retusa, oblíqua ou arredondada, ápice acuminado, cuspidato ou arredondado, margem inteira, faces abaxial e adaxial glabras; nectários foliares ausentes. Inflorescências racemosas, ca. 34-50-floras, axilares. Flores papilionadas, pentâmeras, ressupinadas; cálice gamossépalo, 7,8 × 3,4 mm, tubuloso, verde, glabro; corola dialipétala, lilás a rosa, vexilo ca. 18 × 15 mm, alas ca. 14 × 4 mm, carenas ca. 5 × 13 mm, não espiraladas; estames 10, monadelfos, ca. 16 mm compr., heterodínamos; anteras uniformes, ca. 1 mm compr., rimosas; estaminódios ausentes; ovário ca. 11 mm compr., estipitado, puberulento; estilete ca. 4 mm compr., glabro. Legumes 10,4-11,8 × 2,9-3,1 cm, costados, glabros, deiscentes. Sementes não observadas.
Endêmica do Brasil (Sauer 1964) ocorrendo nas regiões Nordeste (AL, BA, PE), Centro-Oeste (DF) e Sudeste (ES, MG, RJ, SP), nos Domínios Fitogeográficos da Caatinga, Cerrado e Mata Atlântica (Sauer 1964, BFG 2015, material suplementar). No PNMJ ocorre em área Herbácea não inundável. Coletada com flores e frutos em julho.
Difere de Canavalia rosea (Sw.) DC. por ser uma trepadeira (enquanto C. rosea é uma erva prostrada), além de possuir frutos maiores (10,4-11,8 × 2,9-3,1 cm vs. 6,0- 9,5 × 0,8-1 cm em C. rosea). Este é o primeiro registro de ocorrência desta espécie para o PNMJ.
Material examinado: BRASIL. ESPÍRITO SANTO: Parque Natural Municipal de Jacarenema: Vila Velha, 20.VII.2008, H. C. de Lima et al. 7006 (RB).
description: Published as part of Silva, Lucas, Thomaz, Luciana Dias & Dutra, Valquíria Ferreira, 2018, Leguminosae no Parque Natural Municipal de Jacarenema, Vila Velha, Espírito Santo, Brasil, pp. 261-289 in Iheringia, Série Botânica 73 (3) on page 279, DOI: 10.21826/2446-8231201873305, http://zenodo.org/record/10950818
The Impact of Electronic Cigarette and Inhaled Cannabis Co-Use on Cardiovascular Risk in Youth
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cannabis use is increasing, and a large proportion of cannabis users also use tobacco products. Reports estimate that approximately 50% of cannabis users also smoke combustible commercial cigarettes (CCIGs). Although controversial, cannabis use has been associated with increased risk of myocardial infarction (MI). Interestingly, the incidence of MI in adults who smoke both CCIGs and cannabis cigarettes is not significantly greater than that in adults who only smoke CCIGs, consistent with the notion that adverse cardiac effects of cannabis are obscured by the larger negative impact of CCIGs.

 In young people, electronic cigarettes (ECIGs) have largely replaced CCIGs, and in fact, ECIG use has now reached epidemic proportions - with almost 50% of college-aged young adults having reported using ECIGs in the last year. ECIGs are largely perceived to be less harmful than CCIGs – but are not harmless. Additionally, the legalization of cannabis in many states, including California, have contributed to the perception that inhaled combusted cannabis is safe. Approximately 50% of college-aged young adults report inhaled cannabis use within the last year, with the majority reporting co-use (ECIG and inhaled cannabis). It is possible that substitution of ECIGs for CCIGs may unmask the adverse cardiovascular effects of inhaled cannabis. In fact, available data suggest that cannabis use or ECIG use may each have adverse effects on cardiovascular risk factors, including sympathetic nerve activation, inflammation, and oxidative stress, leading to premature atherosclerosis and augmented future cardiac risk. However, it remains unknown if these adverse effects overlap or are additive – or, of greater concern, are synergistic.

 Currently there is a dearth of high-quality data to provide insight into early adverse effects of co-use of ECIGs and cannabis on these cardiovascular risk factors in youth. The current proposal will fill this void by combining our expertise in measuring key cardiovascular biomarkers in humans with our expertise in cannabis research, and our location on the UCLA campus, where prevalence of co-use is high. These data can then be used to inform policymakers and the general public about the dangers of inhaled cannabis and ECIG co-use, and may help counter the perception of cannabis safety that is undercutting present and future tobacco control progress.
title: Bye bye, linearity, bye: quantification of the mean for linear CRNs in a random environment
Creators: name: Sinzger-D’Angelo, Mark
name: Startceva, Sofia
name: Koeppl, Heinz
Publisher: name: Springer
Year: 2025

description: Molecular reactions within a cell are inherently stochastic, and cells often differ in morphological properties or interact with a heterogeneous environment. Consequently, cell populations exhibit heterogeneity both due to these intrinsic and extrinsic causes. Although state-of-the-art studies that focus on dissecting this heterogeneity use single-cell measurements, the bulk data that shows only the mean expression levels is still in routine use. The fingerprint of the heterogeneity is present also in bulk data, despite being hidden from direct measurement. In particular, this heterogeneity can affect the mean expression levels via bimolecular interactions with low-abundant environment species. We make this statement rigorous for the class of linear reaction systems that are embedded in a discrete state Markov environment. The analytic expression that we provide for the stationary mean depends on the reaction rate constants of the linear subsystem, as well as the generator and stationary distribution of the Markov environment. We demonstrate the effect of the environment on the stationary mean. Namely, we show how the heterogeneous case deviates from the quasi-steady state (Q.SS) case when the embedded system is fast compared to the environment.
Reducing Environmental Exposures to Electronic Cigarettes Aerosols and Associated Health Effects
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Electronic cigarette (e-cig) aerosols have been shown to have toxicological effects in cells and animals, as well as adverse respiratory effects among e-cig users. E-cig usage can also result in environmental exposures to secondhand e-cig aerosols for non-users, but the associated health effects are still poorly understood. Previously, we have found extremely high levels of airborne nicotine and particles in vape shops, one of few public indoor spaces permitting unrestricted e-cig use, as well as in those shops' neighboring businesses. Vape shops are more densely distributed in communities with higher proportions of ethnic minorities, and are often in close proximity to schools, raising health disparities concerns especially in terms of environmental exposures to e-cig aerosols among minority adolescence. Building on our previous successful research in vape shops, here we propose a new study focusing on the respiratory health outcomes resulting from environmental exposures to e-cig aerosols among employees of vape shops and their neighboring businesses. The overarching objective is to assess the respiratory effects of environmental exposures to e-cig aerosols and identify effective mitigation measures to reduce such exposures and associated health effects. We will recruit 50 e-cig users and 25 non-users from 50 vape shops in Southern California, and 25 non-users from neighboring businesses. All vape shops will be randomly assigned to two scenarios, either with or without mitigation for one workweek. Then after a one-week washout period without mitigation, vape shops will crossover to the other scenario. The mitigation will include increasing ventilation and using a portable air purifier in the vape shop. For each scenario, two field visits will be conducted on the first and last workday of the workweek. At each field visit, we will measure e-cig related air pollutants and collect urine, saliva, and exhaled breath before and after the work shift to assess exposures and biological effects. Results from this study are expected to provide not only scientific evidence of the potential adverse health effects of environmental exposures to e-cig aerosols, which could inform future policies for e-cigs usage in public spaces, but also provide a practicable method to mitigate environmental exposures to e-cig aerosols and their adverse effects.