cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Forecasting weather impacts on the United Kingdom telecommunication network
Creators: name: Halford, Alan Paul
Publisher: name: University of Reading
Year: 2019

description: The telecommunications network is a crucial part of the national infrastructure of the United Kingdom, with its reliable service becoming an increasingly vital feature of commercial activities and daily life. As with other national infrastructure, weather poses a risk to its operation by caus­ing disruptions in service through faults in the physical network, though the precise relationships between weather and faults are poorly understood. This thesis explores the effect that weather has on the network and demonstrates that by using modem weather forecasting techniques, the nega­tive effects of weather on the network can be minimised. The organisation used for this study is Openreach, a subsidiary of BT and the operator of 87% per cent of UK broadband infrastructure. Using the ERA-Interim reanalysis product, statistical relationships between weather and faults in the telecommunications network are identified in the construction of an impact model, with pre­cipitation identified as the primary historical weather driver for faults. The effects of weather on the network are quantified for the first time using long-term weather data (36 years) and the sta­tistical impact model to produce a consistent "synthetic" fault dataset, demonstrating that weather has a wide range of effects on the network. A multiple linear regression model explains 62% of variability in the fault data, highlighting the importance of weather. Until now, only short-term records (less than 5 years), have been used to quantify weather variability, leading to an under­estimation of the variability. Specifically, a clear seasonality is observed in the fault variability, with winter being the worst performing season, leading to a focus on forecasting this season in this study. Forecasting of faults is performed for weeks two to four in the business planning cycle, aligning with decision timescales in network operations. Large-scale atmospheric patterns are used in the analysis, namely; the North Atlantic Oscillation, as it is shown to have forecast skill at the required time frame. Skill was demonstrated in both deterministic and probabilistic methods of forecasting faults using the North Atlantic Oscillation, with the probabilistic methods demonstrating smaller errors than the deterministic. To assess the impact that using forecast information would have on the telecommunications network, the decision-making processes concerning fault repairs at Openreach are modelled. Using forecasting information, especially probabilistic information, leads to improvements in the key performance indicators used to assess network performance by the regulatory body Ofcom. Importantly, the performance increase is dependent on the nature of the system and the level of flexibility within it. The reactivity or ability of the system to rapidly respond to forecasts changes the usefulness of forecasts to the system, with more value being placed on the forecast in less reactive systems.
title: Deviant subjectivities: monstrosity and kinship in the Gothic imagination
Creators: name: Hayles Gledhill, Evan
Publisher: name: University of Reading
Year: 2019

description: This thesis posits British and American Gothic as a construction of, and critical engagement with, Enlightenment cultures of embodiment and subjectivity: its monsters are reflections on, and explorations of, those figures excluded from the humanist subject position, as it was constructed by John Locke and later Sentimental philosophers. The concept of heteronormative kinship is central to the philosophical understanding of the subject in the modern era; from scientific ideas about genus and species, to philosophical debates about the structure of the nation state, family is the key term. Interrogating kinship and its relation to normativity in texts ranging from Frankenstein to the splatterpunk novels of Clive Barker and Poppy Z. Brite, and nineteenth-century plantation novels to television crime dramas, I argue, is crucial to understanding the cultural construction of humanity itself. Focusing on representations of the monstrous as a deviation from the norm of an able and reproductive body, I centre my analysis on the intersections of gender, sexuality, race, and disability, taking a critical stance informed by critical disability studies and feminist queer theory. Previous studies have read physical anomaly as a metaphor for other minority identities, and so (dis)ability disappears as a question in its own right. In this respect, critical discourse may continue to re-enact Enlightenment structures of domination, hegemony, and universalization, even as they seek to challenge them. Charting Gothic explorations of the relationship between self-subject-citizen and other-object-monster, from their eighteenth century origins to the contemporary era, I examine changing representations of monstrosity and kinship within an historicised context. I argue that what is under consideration in all Gothic art and critique which features the monstrous – no matter its political stance or thematic focus – is the subject itself. These fictions provide a space in which monstrous otherness – a deviant subjectivity – can be expressed and explored as an embodied identity and lived experience.
Supplementary materials 1–6. The Evolution of the Popocatépetl Volcanic Complex: Constraints on Periodic Edifice Construction and Destruction by Sector Collapse
Creators: name: Gisbert, Guillem
name: Delgado-Granados, Hugo
name: Mangler, Martin
name: Prytulak, Julie
name: Espinasa-Pereña, Ramón
name: Petrone, Chiara Maria
Publisher: name: Geological Society of London
Year: 2021
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary materials 1–6
"College Follow-up Study" (Survey)
Creators: name: Alcohol Research Documentation, Inc.
Publisher: name: No Publisher Supplied
Year: 1977

description: Numerous questions divided into 7 sections regarding individual's history, experiences, environment, etc. Contains forms to assess attitudes and behavior concerning alcohol, used as a follow-up to a college drinking survey taken 25 years ago. By Selden D. Bacon.From the Ralph G. Connor Alcohol Research Reference Files (CARRF). CARRF ID: 1.32.
title: I believe I can write: exploring the impact of writing workshops on self-efficacy beliefs of Foundation degree students
Creators: name: Hood, Sonia
Publisher: name: University of Reading
Year: 2019

description: Developing academic writing skills is crucial to degree outcomes but can be specifically challenging for widening participation students. Research suggests that writing support offered to university students should also attend to the affective dimensions of writing, particularly self-efficacy beliefs. This thesis explores the benefits of a writing workshop designed to foster self-efficacy beliefs with the broader aim of contributing to understanding of widening participation into Higher Education. The thesis reports on the impact of a writing self-efficacy intervention, using a quasi-experimental design, to assess the effectiveness of three writing workshop conditions. Forty-two students, following a Foundation degree programme, completed writing self-efficacy questionnaires at three time intervals. Correlational analysis investigated the relationship between assignment grades, academic goals and performance self–efficacy, and further statistical analysis assessed the impact of the different workshop conditions. In addition, qualitative research, in the form of eight semistructured interviews, explored the relative influence of each of the four sources of self-efficacy (mastery experience, vicarious experience, social persuasion and physiological and emotional state) on writing beliefs. The relationship observed between self-efficacy for writing, performance self-efficacy and academic goals evidenced the importance of self-efficacy beliefs to academic attainment. Crucially, a lack of correlation was observed between self-efficacy for writing and writing attainment, with students interpreting their grades inconsistently. While students within the writing self-efficacy workshops experienced an uplift in self-efficacy for writing scores, this was not maintained over time. Mastery and vicarious experiences were fundamental in fostering self-efficacy beliefs, as was having an internal academic locus of control. The research contributes new insights into the importance of an internal locus of control to longterm increases in self-efficacy beliefs. In addition, it contributes to the evidence that it is the student’s interpretation of their grade, not the grade itself, which impacts on their self-efficacy beliefs. This not only furthers our knowledge on the sources of self-efficacy beliefs but has implications for those supporting students to become more efficacious, particular with regards their academic writing.
Exploring cosmological evolution and constraints in $f(T)$ teleparallel gravity
Creators: name: Koussour, M.
name: Altaibayeva, A.
name: Bekov, S.
name: Holmurodov, F.
name: Muminov, S.
name: Rayimbaev, J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: This study explores the extension of teleparallel gravity within the framework of general relativity, introducing an algebraic function $f(T)$ dependent on the torsion scalar $T$. Motivated by the teleparallel formulation, we investigate cosmological implications, employing the simplest parametrization of the dark energy equation of state. Our chosen $f(T)$ function, $f(T)=α(-T)^n$, undergoes stringent constraints using recent observational data ($H(z)$, SNeIa, BAO, and CMB). The model aligns well with cosmic dynamics, exhibiting quintessence behavior. The evolution of the deceleration parameter, the behavior of dark energy components, and the $Om(z)$ diagnostic further reveal intriguing cosmological phenomena, emphasizing the model's compatibility with quintessence scenarios.
description: Physics of the Dark Universe accepted version
title: Use of a calibrated ceilometer network to improve high resolution weather forecasts
Creators: name: Hopkin, Emma
Publisher: name: University of Reading
Year: 2019

description: Ceilometers are simple, relatively inexpensive vertically pointing lidars usually operating at wavelengths of 905-910 nm or 1064 nm that can function reliably unattended for long periods and, as the name suggests, have mainly been used for detecting cloud base at airports where they are valuable for air safety issues. In addition to detecting the large backscattered return from cloud base, they can provide vertical profiles of backscatter from both clouds and aerosols every 5-30 seconds with a range resolution of 10-20 m. This thesis presents a simple and robust method for calibrating ceilometers that has been tested in an operational environment. The method relies on using the integrated backscatter (B) from liquid clouds that totally extinguish the ceilometer signal; B is inversely proportional to the lidar ratio (S) of the backscatter to the extinction for cloud droplets. It is shown that for accurate calibration, care must be taken to exclude any profiles having targets with different values of S, such as drizzle drops and aerosol particles, profiles that do not totally extinguish the ceilometer signal, profiles with low cloud bases that saturate the receiver, and any profiles where the window transmission or the lidar pulse energy is low. A range dependent multiple scattering correction that depends on the ceilometer optics is applied to the attenuated backscatter profiles. A simple correction for water vapour attenuation for ceilometers operating at around 910 nm wavelength is applied to the signal using the vapour profiles from a forecast analysis. The consistency of profiles observed by a pair of co-located ceilometers in the UK Met Office network operating at around 910 nm and 1064 nm provides independent validation of the calibration technique. Secondly, an ice cloud forward model is used to predict attenuated backscatter, using profiles of ice water content (IWC) from the Met Office’s numerical weather prediction model, the UKV. A second moment approximation for particle area and mass is assumed, so that IWC becomes proportional to extinction. The lidar ratio for ice cloud is then used to calculate backscatter from the model derived extinction. The lidar ratio is calculated using ceilometer observations of thick attenuating ice cloud. Comparisons between the UKV derived attenuated backscatter and the attenuated backscatter observed by a ceilometer suggest that the UKV IWC is systematically too small in magnitude and too high in height.
Quantum-Assisted Joint Virtual Network Function Deployment and Maximum Flow Routing for Space Information Networks
Creators: name: Zhang, Yu
name: Gong, Yanmin
name: Fan, Lei
name: Wang, Yu
name: Han, Zhu
name: Guo, Yuanxiong
Publisher: name: arXiv
Year: 2024
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Network function virtualization (NFV)-enabled space information network (SIN) has emerged as a promising method to facilitate global coverage and seamless service. This paper proposes a novel NFV-enabled SIN to provide end-to-end communication and computation services for ground users. Based on the multi-functional time expanded graph (MF-TEG), we jointly optimize the user association, virtual network function (VNF) deployment, and flow routing strategy (U-VNF-R) to maximize the total processed data received by users. The original problem is a mixed-integer linear program (MILP) that is intractable for classical computers. Inspired by quantum computing techniques, we propose a hybrid quantum-classical Benders' decomposition (HQCBD) algorithm. Specifically, we convert the master problem of the Benders' decomposition into the quadratic unconstrained binary optimization (QUBO) model and solve it with quantum computers. To further accelerate the optimization, we also design a multi-cut strategy based on the quantum advantages in parallel computing. Numerical results demonstrate the effectiveness and efficiency of the proposed algorithm and U-VNF-R scheme.
Effect of loss of CDKL5 on brain development in a new Cdkl5 knockout mouse model
Creators: name: Fuchs, Claudia <1983>
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2014
Subjects: BIO/09 Fisiologia

description: Rett's Syndrome (RTT) is a severe neurodevelopmental disorder, characterized by cognitive disability that appears in the first months/years of life. Recently, mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been detected in RTT patients characterized by early-onset seizures. 
CDKL5 is highly expressed in the brain starting from early postnatal stages to adulthood, suggesting the importance of this kinase for proper brain maturation and function. However, the role/s of CDKL5 in brain development and the molecular mechanisms whereby CDKL5 exerts its effects are still largely unknown.

In order to characterize the role of CDKL5 on brain development, we created a mice carrying a targeted conditional knockout allele of Cdkl5. A first behavioral characterization shows that Cdkl5 knockout mice recapitulate several features that mimic the clinical features described in CDKL5 patients and are a useful tool to investigate phenotypic and functional aspects of Cdkl5 loss. 
We used the Cdkl5 knockout mouse model to dissect the role of CDKL5 on hippocampal development and to establish the mechanism/s underlying its actions. We found that Cdkl5 knockout mice showed increased precursor cell proliferation in the hippocampal dentate gyrus. Interestingly, this region was also characterized by an increased rate of apoptotic cell death that caused a reduction in the final neuron number in spite of the proliferation increase. Moreover, loss of Cdkl5 led to decreased dendritic development of new generated granule cells. Finally, we identified the Akt/GSK3-beta signaling as a target of Cdkl5 in the regulation of neuronal precursor proliferation, survival and maturation. 

Overall our findings highlight a critical role of CDKL5/AKT/GSK3-beta signaling in the control of neuron proliferation, survival and differentiation and suggest that CDKL5-related alterations of these processes during brain development underlie the neurological symptoms of the CDKL5 variant of RTT.
Additional file 10 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 10.
Visual impact planning for timber management in British Columbia
Creators: name: Sheppard, Stephen R. J.
Publisher: name: University of British Columbia
Year: 2010

description: Information is needed to help forest managers reduce the visual impact of timber management where the public's image of the landscape may be disrupted. Visual impact magnitude may be assessed by extent of deviation from the characteristic landscape. From analysis of 43 visual impacts in the Windermere Public Sustained Yield Unit (P.S.Y.U.) in south-eastern British Columbia, and from selected literature, the independent and interacting visual effects of seventy timber management practices are identified, and rated as inevident, subordinate, or dominant in comparison with visual elements of the landscape. The visual effect of a given practice in a given forest landscape type is predictable with detailed knowledge of both, in most cases. The visual impact magnitude of a timber: management activity can be predicted from the number of most negative visual effects caused by the combination of management practices used. Practices introducing low visual effects or cancelling those of other practices are identified as landscape design tools. Use of landscape design tools is generally compatible with other forest environmental management aims, though exceptions of local importance are foreseen. Forest administration in British Columbia needs to be modified to accommodate visual constraints on timber management. In a case study in the Cartwright Lakes/Steamboat Mountain area in the Windermere P.S.Y.U., the costs of using design tools instead of conventional practices are estimated in three potential logging sites. Lower visual impact magnitudes can be achieved using common logging systems without significant cost increases, where some timber is left between settings in visually critical sites. Unconventional logging systems can raise or lower costs with or without visual constraints, but use as design tools may reduce extra costs on land that is costly to log. With government cut and leave policy and restrictions on logging methods, use of landscape design tools in high priority sites can have negligible cost increases, but it is not known how widely the case study conditions occur elsewhere. A procedure for visual impact planning is advanced, comprising analysis of biophysical and viewing conditions, identification of forest landscape types and visual objectives and selection of design tools to fit them, detailed planning of visual impacts, and graphic prediction of the outcome. Continuing research is needed to substantiate the study findings, and priorities are suggested.
"Substance Abuse Attitude Survey (SAAS)"
Creators: name: Alcohol Research Documentation, Inc.
Publisher: name: No Publisher Supplied
Year: 1978

description: Copy of survey instruments (brief and full) to measure attitudes of medical students and physicians toward various aspects of alcohol and drug misuse. 53 questions, multiple choice. With handout, information sheet, and article in JSA.From the Ralph G. Connor Alcohol Research Reference Files (CARRF). CARRF ID: 1.42
Additional file 2 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 2.
Additional file 3 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 3.
Shelter Design from recycled GFRP
Creators: name: Lopera-Valle, Adrian
name: Cadena, Daniela
name: Mupani, Simba
Publisher: name: Zenodo
Year: 2021
Subjects: Circular Design
GFRP

description: Reports and drawings on the design of the shelter for its installation in ECOBULK's partner UK universities. The shelter is made from waste-GFRP.
Additional file 4 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 4.
Opinion Mining on Offshore Wind Energy for Environmental Engineering
Creators: name: Bittencourt, Isabele
name: Varde, Aparna S.
name: Lal, Pankaj
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7; I.2.m; J.2

description: In this paper, we conduct sentiment analysis on social media data to study mass opinion about offshore wind energy. We adapt three machine learning models, namely, TextBlob, VADER, and SentiWordNet because different functions are provided by each model. TextBlob provides subjectivity analysis as well as polarity classification. VADER offers cumulative sentiment scores. SentiWordNet considers sentiments with reference to context and performs classification accordingly. Techniques in NLP are harnessed to gather meaning from the textual data in social media. Data visualization tools are suitably deployed to display the overall results. This work is much in line with citizen science and smart governance via involvement of mass opinion to guide decision support. It exemplifies the role of Machine Learning and NLP here.
Additional file 5 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 5.
title: The origins and development of the Labour movement in west London 1918-1970
Creators: name: Humphries, Barbara
Publisher: name: University of Reading
Year: 2019

description: This PhD will look at the origins and development of the labour movement in Ealing and Hillingdon from 1918 to 1970, with a focus on the Labour Party, trades unions, co-operative movement, Independent Labour Party and Communist Party. Written as a ‘history from below’ and based on extensive archival resources, it will assess the role played by different sections of the working class, including ethnic groups (Welsh, Irish and Asians from the Indian Punjab) and women, in forging and sustaining Labour’s presence in west London. In particular, it examines how population change altered the political landscape via large-scale industrialisation in the 1920s and 1930s and the building of new housing estates. Suburbia is considered as a mixed area of working-class communities and middle-class commuter land, feeding into analysis of Labour’s electoral fortunes at the general and local level. Ultimately, the thesis concludes that population change was not responsible alone for the political changes that took place over the century. As important was the building of political organisation at a ‘grassroots level’, thereby necessitating an emphasis on industrial and community organisation. Finally, the thesis evaluates the relationship between national political developments and local politics, feeding into a multi-faceted thesis that contributes to wider debate as to the fluctuating fortunes of Labour in and out of government.
title: Diagnóstico de abscesos: protocolo de RMN rápido y sin contraste EV
Creators: name: Rodriguez Vicari, Juan Carlos Mariano
Publisher: name: Sociedad Española de Radiología Médica
Year: 2014
Subjects: subject: MR-Functional imaging

description: Objetivo docente
Revisión del tema
Conclusiones
Bibliografía
description: Objetivo docente:
Clásicamente la secuencia de difusión se ha utilizado para el diagnóstico de lesiones de SNC,
tanto de abscesos como neoplasias.
Desde hace un tiempo se ha extendido su uso al diagnóstico de neoplasias de cuerpo. El objetivo de este trabajo es...
Additional file 6 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 6.
An alternative approach to the osmotic second virial coefficient of protein solutions and its application to liquid liquid phase separation
Creators: name: Surfaro, Furio
name: Maier, Ralph
name: Pastryk, Kai-Florian
name: Zhang, Fajun
name: Schreiber, Frank
name: Roth, Roland
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The osmotic second virial coefficient B2 is an important parameter to describe the interactions and phase behavior of protein solutions, including colloidal systems and macromolecular solutions. Another key parameter to describe the driving force of the nucleation of a new phase is the supersaturation, which is used in the classical nucleation theory framework and is connected with the favorable contribution in the Gibbs free energy in the bulk solution. In this article, we establish a connection between B2 calculated from small angle Xray scattering (SAXS) data and the values of B2 obtained from supersaturation measurements using thermodynamics considerations. The values of the second virial coefficient calculated employing this method agree with those determined via SAXS in the region near the liquid liquid phase separation border for human serum albumin and bovine serum albumin. The general relations adopted are shown to be useful for the estimation of the second virial coefficient B2 for globular proteins, in the proximity of the binodal biphasic coexistent region.
description: 9 pages, 3 figures
Social Feedback Study 3
Creators: name: Sahi, Razia S.
name: Eisenberger, Naomi
Publisher: name: OSF Registries
Year: 2020
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: We will conduct an exploratory daily diary study to assess the extent to which participants' responses to different forms of social feedback in the Social Feedback Studies extend to their regulatory behaviors and experiences in everyday life.
title: Anti-epileptic effect of cannabidiol mediated by modulation of mitochondrial function
Creators: name: Ibeas Bih, Clementino
Publisher: name: University of Reading
Year: 2024

description: Background and objectives: Cannabidiol (CBD) is a non-psychoactive phytocannabinoid which exerts anti-convulsant effects in both rodents and humans. Although CBD appears to target a wide range of non-mitochondrial and mitochondrial proteins, the molecular mechanism underlying its anti-epileptic effect remains undetermined. In 2013, Rimmerman et al. demonstrated that CBD binds and inhibits the conductance of voltage-dependent anion-selective channel (VDAC) reconstituted in an artificial bilayer membrane. In the mitochondrion, VDAC is essentially expressed in the outer-membrane. Taken together, this led to the hypothesis that CBD may exert its anti-convulsant effect by altering mitochondrial function in a manner which is consistent with that of other VDAC inhibitors. To test this hypothesis, I assessed the effect of CBD on oxidative phosphorylation, Ca2+-induced mitochondrial swelling and cytochrome C release of non-synaptic mitochondria isolated from hippocampi of healthy rats and of rats that have been rendered epileptic following status epilepticus induced chemically with lithium-pilocarpine. Furthermore, the effect of CBD on mitochondrial function was compared to that of a VDAC blocker (namely S18 randomer). Finally, I investigated the effect of CBD on the electrophysiological proprieties of HEK293 cells overexpressing an isoform of VDAC (namely VDAC2). Results: CBD (10 μM) increased mitochondrial swelling and state 4 respiration in non-synaptic mitochondria from epileptic rats, while it exhibited no effect in non-synaptic mitochondria from healthy rats. I showed that CBD does not target complexes II, III and IV or the ATP4- 2 synthase. The direct effect of CBD on mitochondrial swelling and oxidative phosphorylation differed from that of S18 randomer. While S18 randomer dramatically increased Ca2+-induced cytochrome C release, CBD did not exhibit any effect on the latter. Conclusion: CBD induces weak uncoupling and increases Ca2+-induced mitochondrial swelling in non-synaptic mitochondria, suggesting that CBD may activate H+ uptake in these mitochondria. As the effects of CBD were inconsistent with that of S18 randomer, it is very likely that the mechanism of action of CBD is independent from VDAC.
Additional file 7 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 7.
Scaling Laws in High-Energy Inverse Compton Scattering. II. Effect of Bulk Motions
Creators: name: Nozawa, Satoshi
name: Kohyama, Yasuharu
name: Itoh, Naoki
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study the inverse Compton scattering of the CMB photons off high-energy nonthermal electrons. We extend the formalism obtained by the previous paper to the case where the electrons have non-zero bulk motions with respect to the CMB frame. Assuming the power-law electron distribution, we find the same scaling law for the probability distribution function P_{1,K}(s) as P_{1}(s) which corresponds to the zero bulk motions, where the peak height and peak position depend only on the power-index parameter. We solved the rate equation analytically. It is found that the spectral intensity function also has the same scaling law. The effect of the bulk motions to the spectral intensity function is found to be small. The present study will be applicable to the analysis of the X-ray and gamma-ray emission models from various astrophysical objects with non-zero bulk motions such as radio galaxies and astrophysical jets.
description: 10 pages, 3 figures, accepted version by Physical Review D
title: Relevancia del TCMD en el diagnóstico y pronóstico de la isquemia mesentérica aguda
Creators: name: Pérez Alonso, Irene
Publisher: name: Sociedad Española de Radiología Médica
Year: 2014
Subjects: subject: Ischaemia / Infarction
subject: Acute
subject: Diagnostic procedure
subject: Localisation
subject: Contrast agent-intravenous
subject: CT-Angiography
subject: CT
subject: Gastrointestinal tract
subject: Small bowel
subject: Abdomen

description: Objetivo docente
Revisión del tema
Conclusiones
Bibliografía
description: Objetivo docente:
Revisar la variabilidad en la presentación clínica de la isquemia intestinal y su correlación con los signos radiológicos de sospecha y certeza.
Determinar en ocasiones su causa específica,
valorando el pronóstico del cuadro y las...
title: State fragility and international structures: tracing the effects of global war on terrorism (GWoT)
Creators: name: Islam Khan, Mohammad Zahidul
Publisher: name: University of Reading
Year: 2024

description: This research investigates the external drivers of state fragility taking the global war on terrorism (GWoT) as a proxy of international structure. States in a global system do not live in isolation; the ideational and material factors of the international structures can affect states’ trajectory toward resilience or fragility. Accordingly, the research investigates, how and under what conditions the ideational and material factors of the GWoT affects state fragility? State fragility is defined as a condition when a state is incapable of binding the ideational and material factors, leading to the lack of legitimacy amongst its people and/or the capacity to perform core state functions. Fragile condtions are categorised as type-1, type-2 and type-3 fragility based on state’s lacking in capacity, legitimacy or both. The strcuture of the GWoT is defined and theorised under the cognitive, regulatory and capability pathways, through which they can affect fragile states, using the process tracing methodology. Consequently, three case studies on Mali, Bangladesh and Myanmar, representing type-1, 2 and 3 state fragility respectively, test the theorised pathways. The research finds evidence that, in fragile states, the cognitive and capability pathways of the GWoT matters the most, shaping the ‘othering’ process, identity politics and the use of state’s coercive apparatus contributing to fragility. However, it is unclear whether the regulatory pathway has much influence, as it does not strengthen capacity, and they remain poorly implemented in fragile states. The research adds to the extant critical literature on state fragility by offering an original conceptualisation and theorisation of the cognitive, regulatory and capability pathways of the GWoT that can be used to investigate any other case studies or extrapolated to make a similar analysis of, for example, global/regional security or economic structures.
Additional file 8 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 8.
title: RM cardíaca: Una valiosa herramienta para caracterizar el tejido miocárdico
Creators: name: Barrera Portillo, Carmen
Publisher: name: Sociedad Española de Radiología Médica
Year: 2014
Subjects: subject: Tissue characterisation
subject: MR
subject: Cardiovascular system
subject: Cardiac

description: Objetivo docente
Revisión del tema
Conclusiones
Bibliografía
description: Objetivo docente:
La RM es una técnica de imagen que ha demostrado ampliamente su utilidad para estudiar de forma precisa los cambios morfológicos y funcionales que puedan acontecer en diversas patologías cardíacas.
Además de eso,
las secuencias utilizadas,
sin...
title: Diagnóstico del colesteatoma mediante imagen de difusión no EPI
Creators: name: Montoya Bordón, Julia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2014
Subjects: subject: Ear / Nose / Throat
subject: MR-Diffusion/Perfusion
subject: Imaging sequences

description: Objetivos
Material y método
Resultados
Conclusiones
Bibliografía
description: Objetivos:
Determinación de validez y exactitud de la secuencia de difusión no echo plannar (DW no EPI) en RMpara detección del colesteatoma del oído...
Autoritarismo y nacionalismo en la frontera. El legado de las dictaduras en la Norpatagonia chileno—argentina
Creators: name: Nuñez, Paula Gabriela
name: Freddi, Andrea
name: González, Lucaz
Publisher: name: Confluenze. Rivista di Studi Iberoamericani
Year: 2023

description: Este artículo compara el modo en que se recuerdan las tensiones y enfrentamientos entre Argentina y Chile a partir de las memorias de violencia de una región marginal y fronteriza, en los valles de los ríos Cochamó, Manso y Puelo, comprendidos entre Chile Argentina. Nos enfocamos en particular en las consecuencias del conflicto del Beagle de 1978, cuando las dictaduras de los dos países estuvieron a punto de entrar en guerra. En el territorio en análisis, este episodio impactó la vida cotidiana y la percepción del Otro, caracterizados históricamente por una dinámica relacional transfronteriza.
description: Confluenze. Rivista di Studi Iberoamericani, V. 15 N. 2 (2023): Tra passato e presente. Una riflessione sull’eredità autoritaria
Additional file 9 of The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
Creators: name: Yiga, Peter
name: Van Lippevelde, Wendy
name: Seghers, Jan
name: Ogwok, Patrick
name: Tafiire, Henry
name: Muluuta, Susan Nakaayi
name: Matthys, Christophe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 9.
Ecological features of moose Alces alces andersoni winter habitat in the boreal white and black spruce zone of northeastern British Columbia
Creators: name: Silver, Roderick Sterling
Publisher: name: University of British Columbia
Year: 2010

description: A study of the dispersion patterns of moose in winter habitats was conducted from June 1972 to May 1974 in a wildlife reserve in northeastern British Columbia. Major factors affecting the patterns were examined in an attempt to determine their relative importance. Data from eight representative vegetation plots indicated productive browse in deciduous forests and open habitats. In coniferous forest there was very little shrub development. Moose were well adapted to low winter temperatures which often followed warm winter temperatures associated with Chinook winds. Snow cover rarely exceeded 76 cm. Canopies of mature coniferous forest profoundly influenced the depth of snow on the ground, but, because the snow depth in open areas was not restrictive, moose did not extensively use coniferous forest. Willow, aspen and bog birch were the most important forage species. Rumen analyses and trailing methods supported these observations. Instances of moose cratering (pawing) and debarking were observed. Winter forages (probably a limited sample) were very low in crude protein. Open shrubland, agricultural land, and deciduous forest were preferred winter habitat. Several variables, quantified during ground and aerial observations, were used in a model to predict moose dispersion, but the model was applied with limited success. Future management of habitat for moose should include logging and prescribed burning to enhance the forage resource. The purchase of alienated lands to ensure control of the land base is also recommended.
Constraints on anisotropic properties of the universe in $f(Q, T)$ gravity theory
Creators: name: Zhadyranova, A.
name: Koussour, M.
name: Zhumabekova, V.
name: Donmez, O.
name: Muminov, S.
name: Rayimbaev, J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Motivated by anomalies in cosmic microwave background observations, we investigate the implications of $f(Q, T)$ gravity in Bianchi type-I spacetime, aiming to characterize the universe's spatially homogeneous and anisotropic properties. By using a linear combination of non-metricity $Q$ and the energy-momentum tensor trace $T$, we parametrize the deceleration parameter and derive the Hubble solution, which we then impose in the Friedmann equations of $f(Q, T)$ gravity. Bayesian analysis is employed to find the best-fit values of model parameters, with $1-σ$ and $2-σ$ contour plots illustrating the constraints from observational data, including $H(z)$ data and the Pantheon+ sample. Our analysis reveals a transition from a decelerated to an accelerated expansion phase, with the present deceleration parameter indicating an accelerating universe. The energy density gradually decreases over time, approaching zero for the present and future, indicating continuous expansion. The anisotropic pressure, initially notably negative, transitions to slightly negative values, suggesting the presence of dark energy. The evolving equation of state parameter $ω$ exhibits behavior akin to phantom energy, influenced by spacetime anisotropy. Violations of the null energy condition and the strong energy condition imply phantom-like behavior and accelerated expansion.
description: Journal of High Energy Astrophysics accepted version
On the Fragility of Alfvén waves in a Stratified Atmosphere
Creators: name: Cally, Paul S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Complete asymptotic expansions are developed for slow, Alfvén and fast magnetohydrodynamic waves at the base of an isothermal three-dimensional (3D) plane stratified atmosphere. Together with existing convergent Frobenius series solutions about $z=\infty$, matchings are numerically calculated that illuminate the fates of slow and Alfvén waves injected from below. An Alfvén wave in a two-dimensional model is 2.5D in the sense that the wave propagates in the plane of the magnetic field but its polarization is normal to it in an ignorable horizontal direction, and the wave remains an Alfvén wave throughout. The rotation of the plane of wave propagation away from the vertical plane of the magnetic field pushes the plasma displacement vector away from horizontal, thereby coupling it to stratification. It is shown that potent slow-Alfvén coupling occurs in such 3D models. It is found that about 50% of direction-averaged Alfvén wave flux generated in the low atmosphere at frequencies comparable to or greater than the acoustic cutoff can reach the top as Alfvén flux for small magnetic field inclinations $θ$, and this increases to 80% or more with increasing $θ$. On the other hand, direction-averaged slow waves can be 40% effective in converting to Alfvén waves at small inclination, but this reduces sharply with increasing $θ$ and wave frequency. Together with previously explored fast-slow and fast-Alfvén couplings, this provides valuable insights into which injected transverse waves can reach the upper atmosphere as Alfvén waves, with implications for solar and stellar coronal heating and solar/stellar wind acceleration.
description: 14 pages, 6 figures, accepted (26 Nov 2021) for publication in MNRAS
Additional file 1 of The impact of COVID-19 on the well-being, education and clinical practice of general practice trainees and trainers: a national cross-sectional study
Creators: name: Coenen, Lotta
name: Poel, Louise Vanden
name: Schoenmakers, Birgitte
name: Van Renterghem, Arne
name: Gielis, Guy
name: Remmen, Roy
name: Michels, Nele R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Study survey for GP trainees.
A thesis on eh
Creators: name: Gibson, Deborah Jean
Publisher: name: University of British Columbia
Year: 2010

description: Several linguists have noted that eh is a distinct characteristic of Canadian English, e.g., Allen (1959), Avis (1972), and Love (1973). Despite this common observation, little detailed analysis has been done on either eh's syntactic or sociolinguistic distribution. Avis (1972), for example, discusses a number of the syntactic environments of eh, but based on its occurrence in selected works of literature. Thus far there has been no detailed study on the systematic use of eh as it is found in the spoken language, used by a diversity of speakers. This paper gives a grammatical and sociolinguistic analysis of the use of eh, based on data collected in Vancouver, B.C., over a period of four months. The data consist of more than 550 occurrences of eh from 74 informants of various language and social backgrounds. Most informants were native speakers of Canadian English, with the others being primarily speakers of either American or British English. The grammatical analysis presents the syntactic and semantic characteristics of eh and its uses. It is in part based on research on tags (e.g., Huddleston 1970, Cattell 1973), questions (e.g., Hudson 1975), and conversational analysis (e.g., Sacks 1967). Important properties of sentences that determine the analysis and use of eh include syntactic mood, semantic force, and sincerity conditions. Also, eh can only be understood by extending the analysis to include the relation between sentences within a discourse. The sociolinguistic analysis is based on information about the speakers who use eh and on the social context in which it occurs, i.e., formal versus informal usage. Social variables in the use of eh are age, class, sex, regional and language background of the speaker. [Table on eight types of eh] The sociolinguistic analysis indicates that eh is used mostly in informal speech, that some speakers use eh more than others, and that the variables of class and regional background may determine the use of certain types of eh, particularly the Anecdotal eh, which was found to be the most stigmatized form.