cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
hnRNP L and NF90 Interact with Hepatitis C Virus 5'-Terminal Untranslated RNA and Promote Efficient Replication
Creators: name: Shimakami, T.
name: Masaki, T.
name: Li, Y.
name: Lemon, S. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The 5′-terminal sequence of the hepatitis C virus (HCV) positive-strand RNA genome is essential for viral replication. Critical host factors, including a miR-122/Ago2 complex and poly(rC)-binding protein 2 (PCBP2), associate with this RNA segment. We used a biotinylated RNA pulldown approach to isolate host factors binding to the HCV 5′ terminal 47 nucleotides and, in addition to Ago2 and PCBP2, identified several novel proteins, including IGF2BP1, hnRNP L, DHX9, ADAR1, and NF90 (ILF3). PCBP2, IGF2BP1, and hnRNP L bound single-stranded RNA, while DHX9, ADAR1, and NF90 bound a cognate double-stranded RNA bait. PCBP2, IGF2BP1, and hnRNP L binding were blocked by preannealing the single-stranded RNA bait with miR-122, indicating that they bind the RNA in competition with miR-122. However, IGF2BP1 binding was also inhibited by high concentrations of heparin, suggesting that it bound the bait nonspecifically. Among these proteins, small interfering RNA-mediated depletion of hnRNP L and NF90 significantly impaired viral replication and reduced infectious virus yields without substantially affecting HCV internal ribosome entry site-mediated translation. hnRNP L and NF90 were found to associate with HCV RNA in infected cells and to coimmunoprecipitate with NS5A in an RNA-dependent manner. Both also associate with detergent-resistant membranes where viral replication complexes reside. We conclude that hnRNP and NF90 are important host factors for HCV replication, at least in cultured cells, and may be present in the replication complex.
Recoiling Supermassive Black Holes: a search in the Nearby Universe
Creators: name: Lena, D.
name: Robinson, A.
name: Marconi, A.
name: Axon, D. J.
name: Capetti, A.
name: Merritt, D.
name: Batcheldor, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The coalescence of a binary black hole can be accompanied by a large gravitational recoil due to anisotropic emission of gravitational waves. A recoiling supermassive black hole (SBH) can subsequently undergo long-lived oscillations in the potential well of its host galaxy, suggesting that offset SBHs may be common in the cores of massive ellipticals. We have analyzed HST archival images of 14 nearby core ellipticals, finding evidence for small ($\lesssim 10$ pc) displacements between the AGN (locating the SBH) and the center of the galaxy (the mean photocenter) in 10 of them. Excluding objects that may be affected by large-scale isophotal asymmetries, we consider six galaxies to have detected displacements, including M87, where a displacement was previously reported by Batcheldor et al. 2010. In individual objects, these displacements can be attributed to residual gravitational recoil oscillations following a major or minor merger within the last few Gyr. For plausible merger rates, however, there is a high probability of larger displacements than those observed, if SBH coalescence took place in these galaxies. Remarkably, the AGN-photocenter displacements are approximately aligned with the radio source axis in four of the six galaxies with displacements, including three of the four having relatively powerful kpc-scale jets. This suggests intrinsic asymmetries in radio jet power as a possible displacement mechanism, although approximate alignments are also expected for gravitational recoil. Orbital motion in SBH binaries and interactions with massive perturbers can produce the observed displacement amplitudes but do not offer a ready explanation for the alignments.
description: 58 pages, 32 figures, 9 tables. Accepted for publication in ApJ
Additional file 1 of Compliance of healthcare workers in a psychiatric inpatient ward to infection control practices during the COVID-19 pandemic: a participant observation study supplemented with a self-reported survey
Creators: name: Lau, Leonia Hiu Wan
name: Lam, Queenie Shing Kwan
name: Siu, Minnie Mei Yi
name: Tang, Tiffany Sze Ki
name: Suen, Lorna Kwai Ping
name: Lam, Simon Ching
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
The Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry-BLASTPol: Performance and results from the 2012 Antarctic flight
Creators: name: Galitzki, N.
name: Ade, P. A. R.
name: Angilé, F. E.
name: Benton, S. J.
name: Devlin, M. J.
name: Dober, B.
name: Fissel, L. M.
name: Fukui, Y.
name: Gandilo, N. N.
name: Klein, J.
name: Korotkov, A. L.
name: Matthews, T. G.
name: Moncelsi, L.
name: Netterfield, C. B.
name: Novak, G.
name: Nutter, D.
name: Pascale, E.
name: Poidevin, F.
name: Savini, G.
name: Scott, D.
name: Shariff, J. A.
name: Soler, J. D.
name: Tucker, C. E.
name: Tucker, G. S.
name: Ward-Thompson, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry (BLASTPol) is a suborbital mapping experiment, designed to study the role played by magnetic fields in the star formation process. BLASTPol observes polarized light using a total power instrument, photolithographic polarizing grids, and an achromatic half-wave plate to modulate the polarization signal. During its second flight from Antarctica in December 2012, BLASTPol made degree scale maps of linearly polarized dust emission from molecular clouds in three wavebands, centered at 250, 350, and 500 microns. The instrumental performance was an improvement over the 2010 BLASTPol flight, with decreased systematics resulting in a higher number of confirmed polarization vectors. The resultant dataset allows BLASTPol to trace magnetic fields in star-forming regions at scales ranging from cores to entire molecular cloud complexes.
description: Presented at SPIE Ground-based and Airborne Telescopes V, June 23, 2014
Impact of Clade, Geography, and Age of the Epidemic on HIV-1 Neutralization by Antibodies
Creators: name: Giorgi, E.
name: Kim, J. H.
name: Harris, L.
name: Hraber, P.
name: Seaman, M. S.
name: Lapedes, A. S.
name: Thomson, M. M.
name: Gao, H.
name: Bailer, R. T.
name: Williamson, C.
name: Gao, F.
name: Swanstrom, R.
name: Montefiori, D. C.
name: Hahn, B. H.
name: Korber, B. T.
name: Mascola, J. R.
name: Hengartner, N.
name: Greene, K. M.
name: Tovanabutra, S.
name: Bhattacharya, T.
name: McCutchan, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Neutralizing antibodies (nAbs) are a high priority for vaccines that aim to prevent the acquisition of HIV-1 infection. Vaccine effectiveness will depend on the extent to which induced antibodies neutralize the global diversity of circulating HIV-1 variants. Using large panels of genetically and geographically diverse HIV-1 Env-pseudotyped viruses and chronic infection plasma samples, we unambiguously show that cross-clade nAb responses are commonly induced in response to infection by any virus clade. Nonetheless, neutralization was significantly greater when the plasma clade matched the clade of the virus being tested. This within-clade advantage was diminished in older, more-diverse epidemics in southern Africa, the United States, and Europe compared to more recent epidemics in Asia. It was most pronounced for circulating recombinant form (CRF) 07_BC, which is common in China and is the least-divergent lineage studied; this was followed by the slightly more diverse Asian CRF01_AE. We found no evidence that transmitted/founder viruses are generally more susceptible to neutralization and are therefore easier targets for vaccination than chronic viruses. Features of the gp120 V1V2 loop, in particular, length, net charge, and number of N-linked glycans, were associated with Env susceptibility and plasma neutralization potency in a manner consistent with neutralization escape being a force that drives viral diversification and plasma neutralization breadth. The overall susceptibility of Envs and potencies of plasma samples were highly predictive of the neutralization outcome of any single virus-plasma combination. These findings highlight important considerations for the design and testing of candidate HIV-1 vaccines that aim to elicit effective nAbs.
Monarchia e arcana imperii. Corpo, simboli, liturgie. Editoriale di Engramma 202
Creators: name: Centanni, Monica;Lollini, Fabrizio
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: subject: The King Two Bodies
subject: Monarchy
subject: arcana imperii

description: Engramma’s issue 202, “Monarchy and arcana imperii. Body, symbols, liturgies”, was published in May 2023, just a few weeks after the world-wide broadcasted coronation of Charles III, King of England, which took place on 6 May. The topic of the Monarchy and the King’s Body emerged with absolute relevance and urgency due to the legacies that interfere with its contemporary imagery. A view on the subject from both a theoretical and political perspective is proposed in Peppe Nanni’s paper Finzioni che non funzionano: due corpi di troppo. Monica Centanni expands on the theme of the King’s two bodies from Kantorowicz’s seminal text in her Explicit tragoedia.The Undressing of the King’s Body: Xerxes, Constantine XI Palaeologus, Richard II (also in full Italian version) Rex Iudaeorum”. Citare in giudizio un titolo regale? by Letizia Biazzo is dedicated to the titulus “Rex Judaeorum”, imposed on Christ’s cross as a motivation for simultaneous condemnation and mockery, accompanied by a gallery of examples on the iconography of the trilingual epigraph. The essay “Vigilasne rex? Vigila”. Il doppio corpo del re e le sue bellicose resurrezioni primaverili by Barbara Biscotti and Matteo Alberio focuses on the archaic institutions of Kingship in Roman institutional culture (and that of the names rex and βασιλεύς). A historical, as well as legal, reading of the inventio of the holy oil, linked to the miracles of the first princeps, Augustus, is the topic of an important paper by Orazio Licandro, “Odium regni" e “olio santo” da Augustus alla res publica christianorum. Jelena Erdeljan focuses on the rituality of Serbian medieval monarchy in her Royal bodies of Serbian medieval kings. Entwined in the vine of salvation. From Antiquity to the Modern age, passing through Byzantium and the Middle Ages, the King’s body also stands at the centre of a series of dangerous relationships. Massimo Stella’s fine contribution, Corpo sovrano e sovversione del corpo cristiano. Edward II tra Amor ovidiano e mors paolina, illuminates this constellation of meanings, taking the cue from Marlowe’s text. The aloofness in itself is a common trait of the images of kings and emperors. It is similar to that enacted by Christ (and, more figuratively, by the Virgin and other saints), as a signum of belonging to another world, and of a deactivated personal empathy towards the visual user. Composure, in fact, deletes emotions – as it was until the time of Hirohito, the predecessor of the last two Japanese Emperors – and it is the last example of God on earth until the renunciation of sacred dignity in Tenno no ningen sengen, in 1946. On the topic, we publish here an evocative note by Kurt Foster, Fosco Maraini. The Man Who Wondered About The Kingship of Tennō.
A Framework for Developing a Regional Freight Transport Observatory
Creators: name: Tong, Hing Yan
name: Matopoulos, Aristides
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Last-mile logistics
City logistics
Freight data sharing
Freight data analytics

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Previous research has highlighted the lack of freight data as a significant barrier to producing evidence-based freight policy planning. This lack of freight flow visibility makes the formulation of freight policy a piecemeal. The aim of this research is to look at the feasibility and the requirements for establishing a Regional Freight Transport Observatory (RFTO). Eight cases around the world are analysed according to a framework that is consistent with the five dimensions of data stickiness. This research provides a profile of the current state-of-the-art practices in urban freight data sharing which lead to the generation of key ideas for the establishment of the RFTO. Analysis showed that the formulation of freight policy received very limited attention which confirms the need for the proposed research about the RFTO. An independent, neutral, third-party trustee could be a useful approach for transport and logistics data sharing. RFTO is a novel concept that advocates a partnership between public and private stakeholders in securely sharing regional freight traffic information and thus could provide improved visibility on urban freight traffic movements with the goal to inform and support freight policy development and to help develop better approaches to support freight logistics practices in urban areas.
Interaction of Kaposi's Sarcoma-Associated Herpesvirus ORF6 Protein with Single-Stranded DNA
Creators: name: Griffith, J.
name: Ozgur, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Kaposi's sarcoma-associated herpesvirus (KSHV) ORF6 is homologous to the herpes simplex virus 1 (HSV-1) ICP8 and Epstein-Barr virus (EBV) BALF2 proteins. Here, we describe its single-stranded DNA (ssDNA) binding properties. Based on previous findings with ICP8 and BALF2, a 60-amino-acid C-terminal deletion mutant of Orf6 was generated, and the protein was purified to explore the function of the C terminus in ssDNA binding. We showed that full-length ORF6 binds cooperatively to M13 ssDNA, disrupting its secondary structure and extending it to a length equivalent to that of duplex M13 DNA. The width of the ORF6-ssDNA filament is 9 nm, and a 7.3-nm repeat can be distinguished along the filament axis. Fluorescence polarization analysis revealed that the wild-type and C-terminal mutant ORF6 proteins bind equally well to short ssDNA substrates, with dissociation constant (Kd) values of 2.2 × 10−7M and 1.5 × 10−7M, respectively. These values were confirmed by electrophoretic mobility shift assay (EMSA) analysis, which also suggested that binding by the full-length protein may involve both monomers and small multimers. While no significant difference in affinities of binding between full-length ORF6 and the C-terminal deletion mutant were observed with the short DNAs, binding of the C-terminal mutant protein to M13 ssDNA showed a clear lack of cooperativity as seen by electron microscopy (EM). Incubation of a duplex DNA containing a long single-stranded tail with double-helical ORF6 protein filaments revealed that the ssDNA segment can be enveloped within the protein filament without disrupting the filament structure.
Logica laurentiana. Studio sui libri II e III della dialettica di Lorenzo Valla
Creators: name: Castaldo, Paolo
Publisher: name: Universita degli studi di Salerno
Year: 2017
Subjects: subject: M-FIL/01 FILOSOFIA TEORETICA
subject: Logica
subject: Retorica

description: 2015 - 2016
description: La mia Tesi di Dottorato ha ad oggetto la logica elaborata da Lorenzo Valla nel secondo e terzo libro della Dialectica, la sua principale opera filosofica. La logica del Valla, da lui stesso definita «logica laurentiana», mira a riformare la logica aristotelica e medievale attraverso l’introduzione di una serie di principi mutuati dalla retorica e dalla grammatica. La mia tesi intende mostrare l’incisività di questi principi sul paradigma aristotelico, almeno rispetto ai momenti presi in considerazione dal Valla. Lungi dal separare la retorica dalla logica, o il punto di vista oratorio dal punto di vista logico/filosofico, Valla intende dare vita a un nuovo corso della logica attraverso una rifondazione del metodo antico. Alla luce di ciò, va anche rivisto un altro topos esegetico diffuso tra gli studiosi della Dialectica, vale a dire la riduzione della dialettica alla retorica. Valla mantiene l’autonomia (ancorché non l’indipendenza) della dialettica dalla retorica, riconoscendo alla prima uno spazio distinto e separato dalla seconda poiché diverso è l’oggetto delle due artes. [a cura dell'Autore]
description: My PhD thesis is concerned with logic developed by Lorenzo Valla in the second and third book of the Dialectica, his main philosophical work. Valla’s logic, by himself named «logica laurentiana», aim to reform aristotelian and medieval logic introducing a series of principles borrowed by rhetoric and grammar. The purpose of my thesis is to show the deep influence of this principles on the aristotelian paradigm, at least on moments that Valla is concerned with. Far from separate rhetoric from logic, or the oratorical point of view from the philosophical/logical point of view, Valla intends to give birth to a new course of logic through a refoundation of old method. In light of that, it must be reviewed another exegetical topos widespread among Dialectica’s scholars: the reduction of dialectic to rhetoric. Valla mantains the autonomy (but not the indipendence) of dialectic from rhetoric, and he grants to the first a separate space from second because the obiect of these two artes is different. [edited by Author]
Additional file 1 of Socio-demographic and lifestyle factors associated with intrinsic capacity among older adults: evidence from India
Creators: name: Muneera, K.
name: Muhammad, T.
name: Althaf, S
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. Differences in socio-demographic characteristics of included and excluded sample in the study. Table S2. VIF estimates for the selected explanatory variables. Figure S1. Kernel density plot showing the normality of residuals.
Measuring Efficiency of Automated Road Freight Transport: The AWARD Approach
Creators: name: Neubauer, Matthias
name: Schildorfer, Wolfgang
name: Walch, Manuel
name: Koskinen, Sami
name: Hashimy, Loha
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: L4 autonomous freight transport
Vehicle efficiency
Fleet management efficiency

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Autonomous vehicles will be a key ingredient of future road transport solutions. Even if significant progress has been made in technological developments and autonomous transport vehicle demonstrations, there are still challenges to be addressed before widespread adoption can occur, e.g., 24/7 availability in harsh weather conditions. Quantifying the performance of autonomous vehicles is crucial for logistics operators when deploying such solutions. This Paper presents KPIs related to autonomous road freight transport. Furthermore, the evaluation methodology of the European H2020 project AWARD related to efficiency of autonomous vehicles is presented and initial insights from the project are sketched.
A domain adaptive deep learning solution for scanpath prediction of paintings
Creators: name: Kerkouri, Mohamed Amine
name: Tliba, Marouane
name: Chetouani, Aladine
name: Bruno, Alessandro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Cultural heritage understanding and preservation is an important issue for society as it represents a fundamental aspect of its identity. Paintings represent a significant part of cultural heritage, and are the subject of study continuously. However, the way viewers perceive paintings is strictly related to the so-called HVS (Human Vision System) behaviour. This paper focuses on the eye-movement analysis of viewers during the visual experience of a certain number of paintings. In further details, we introduce a new approach to predicting human visual attention, which impacts several cognitive functions for humans, including the fundamental understanding of a scene, and then extend it to painting images. The proposed new architecture ingests images and returns scanpaths, a sequence of points featuring a high likelihood of catching viewers' attention. We use an FCNN (Fully Convolutional Neural Network), in which we exploit a differentiable channel-wise selection and Soft-Argmax modules. We also incorporate learnable Gaussian distributions onto the network bottleneck to simulate visual attention process bias in natural scene images. Furthermore, to reduce the effect of shifts between different domains (i.e. natural images, painting), we urge the model to learn unsupervised general features from other domains using a gradient reversal classifier. The results obtained by our model outperform existing state-of-the-art ones in terms of accuracy and efficiency.
description: Accepted at CBMI2022 graz, austria
Involvement of Hepatitis C Virus NS5A Hyperphosphorylation Mediated by Casein Kinase I-  in Infectious Virus Production
Creators: name: Takahashi, H.
name: Matsuda, M.
name: Matsunaga, S.
name: Sawasaki, T.
name: Suzuki, T.
name: Wakita, T.
name: Hirano, H.
name: Kato, T.
name: Endo, Y.
name: Kimura, Y.
name: Ito, M.
name: Lemon, S. M.
name: Masaki, T.
name: Murayama, A.
name: Nakashima, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) possesses multiple functions in the viral life cycle. NS5A is a phosphoprotein that exists in hyperphosphorylated and basally phosphorylated forms. Although the phosphorylation status of NS5A is considered to have a significant impact on its function, the mechanistic details regulating NS5A phosphorylation, as well as its exact roles in the HCV life cycle, are still poorly understood. In this study, we screened 404 human protein kinases via in vitro binding and phosphorylation assays, followed by RNA interference-mediated gene silencing in an HCV cell culture system. Casein kinase I-α (CKI-α) was identified as an NS5A-associated kinase involved in NS5A hyperphosphorylation and infectious virus production. Subcellular fractionation and immunofluorescence confocal microscopy analyses showed that CKI-α-mediated hyperphosphorylation of NS5A contributes to the recruitment of NS5A to low-density membrane structures around lipid droplets (LDs) and facilitates its interaction with core protein and the viral assembly. Phospho-proteomic analysis of NS5A with or without CKI-α depletion identified peptide fragments that corresponded to the region located within the low-complexity sequence I, which is important for CKI-α-mediated NS5A hyperphosphorylation. This region contains eight serine residues that are highly conserved among HCV isolates, and subsequent mutagenesis analysis demonstrated that serine residues at amino acids 225 and 232 in NS5A (genotype 2a) may be involved in NS5A hyperphosphorylation and hyperphosphorylation-dependent regulation of virion production. These findings provide insight concerning the functional role of NS5A phosphorylation as a regulatory switch that modulates its multiple functions in the HCV life cycle.
HD139614: the interferometric case for a group-Ib pre-transitional young disk
Creators: name: Labadie, Lucas
name: Matter, Alexis
name: Kreplin, Alexander
name: Lopez, Bruno
name: Wolf, Sebastian
name: Weigelt, Gerd
name: Ertel, Steve
name: Berger, Jean-Philippe
name: Pott, Jorg-Uwe
name: Danchi, William C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The Herbig Ae star HD 139614 is a group-Ib object, which featureless SED indicates disk flaring and a possible pre-transitional evolutionary stage. We present mid- and near-IR interferometric results collected with MIDI, AMBER and PIONIER with the aim of constraining the spatial structure of the 0.1-10 AU disk region and assess its possible multi-component structure. A two-component disk model composed of an optically thin 2-AU wide inner disk and an outer temperature-gradient disk starting at 5.6 AU reproduces well the observations. This is an additional argument to the idea that group-I HAeBe inner disks could be already in the disk-clearing transient stage. HD 139614 will become a prime target for mid-IR interferometric imaging with the second-generation instrument MATISSE of the VLTI.
description: SPIE Astronomical Telescopes and Instrumentation conference, June 2014, 11 pages, 7 Figures
Additional file 1 of Significant drop in serum C-reactive protein in patients with solid neoplasia and bacterial infection is associated with a better prognosis and identifies candidates for short-course antibiotic therapy
Creators: name: de Barros, Guilherme Monteiro
name: Borges, Isabela Nascimento
name: Ravetti, Cecilia Gómez
name: Diniz, Paulo Henrique
name: Ferreira, Samuel Rosa
name: De Mori, Lara Hemerly
name: Castro, Rafael
name: Okamura, Getúlio H.
name: Gatto, Felipe
name: Nobre, Vandack
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
A Proposal and Evaluation of a Digital Twin Framework for PI-Hubs using Re-enforcement Learning based Multi-Agent Systems Model
Creators: name: Vijay, Anshul
name: Thompson, Russell G.
name: Nassir, Neema
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Pi-hubs
Data standards
Automation
Collaboration
Operational planning
Digital twin
Hyperconnected city logistics
Goods to vehicle allocation problem

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: The Physical Internet (PI) provides a way to enhance logistic network performance spanning the social, financial, and environmental domains. Hyperconnected City Logistics (HCL) encompasses logistic activities arising within PI across the greater metropolitan region. To enable PI to operate as an open, collaborative network, a standard form of data exchange amongst network participants is required. GS1 Scan 4 Transport’s Digital Link (GS1DL) is a data sharing standard enabling tracking of products through the supply chain. This includes the realization of shorter and more consistent processing times at goods transfer points within facilities. The potential impact of utilizing the GS1DL within a collaborative environment is yet to be investigated. Digital Twin (DT) enables real-time monitoring of assets’ statuses and tracking of containers, leading to a real-time virtual representation of the physical facility, integrating the various computer network systems. This study proposes a novel Digital Twin framework for PI-Hubs, integrating a re-enforcement learning based multi-agent system (MAS). Real-time location of goods flowing through the facility will be used by machine learning to predict the likelihood of containers arriving at the outbound docks, to be subsequently re-allocated to outbound vehicles via a reallocation optimization algorithm. The evaluation of the DT framework on PI-Hub's operational performance will include the assessment of Scan4Transport’s Digital Link standard.
Identification of cargo bikes and drones related challenges, potential strengths and benefits to achieve sustainable futures
Creators: name: Chatziioannou, Ioannis
name: Athanasopoulos, Konstantinos
name: Papageorgas, Iason Plymenos
name: Merntani, Anestis
name: Petrakou, Zoe
name: Karolemeas, Christos
name: Bakogiannis, Efthimios
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Pi-hubs
Cargo bikes
Unmanned aerial vehicles
Drones
Green logistics

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Nowadays, there is an ever-increasing acceptance regarding the opinion that the use of more sustainable urban freight transport has the potential to offer great energy and efficiency benefits which can be handled through the appropriate combination of various measures such as: The creation of small urban supply chain centres, the use of clean vehicles and technologies with a low environmental footprint, the establishment of "first or last mile" value-added services and the smooth integration of urban freight transport within the framework of urban mobility´s management. This study examines, via an extensive literature review, the potential strengths, benefits, and challenges of the implementation of drones and cargo bikes for the last-mile deliveries in the urban logistics sector and specifically in large urban environments. The aforementioned literature review revealed the importance of different weather conditions on the flying capabilities of the unmanned aerial vehicles and the quality of urban environment´s components upon the safe delivery of goods through the utilisation of cargo bikes. Ultimate goal of this study is to contribute in tackling identified challenges, so the drone and cargo bikes implementation may become possible to a larger degree and deliver even more value to the logistic companies and the society.
Behavioral and theoretical considerations of physical internet adoption
Creators: name: Pournader, Mehrdokht
name: Thompson, Russell G.
name: Foliente, Greg
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Physical Internet
Supply network
Behaviour theory

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Physical internet (PI) is an ambitious project spanning across firms, supply chains and countries to make a consolidated and interconnected network of logistics for handling goods. Alliance for Logistics Innovation through Collaboration in Europe (ALICE) proposes five areas of development as the roadmap for PI which include technical/operational aspects of PI (i.e., “From Logistics Nodes to PI Nodes”, “From Logistics Networks to Physical Internet Networks”, and “Developing the System of Logistics Networks towards the Physical Internet”) as well as human aspects of PI (i.e., “Access and Adoption” and “Governance”). While most scientific literature on PI has been primarily focused on the technical/operational aspects of PI, very few studies have so far looked into the human aspects of PI. Issues such as trust in PI networks or simply adoption and acceptance of PI require an understanding of human behavior on individual and firm/socials levels, to say the least. To this end we have investigated a number of major behavioral and technology-adoption theories to explore some future topics for research in the PI domain with respect to “Access and Adoption” and “Governance”. The theoretical frameworks investigated in this manuscript are on individual level (e.g., Theory of Reasoned Action and Technology Acceptance Model) and firm/social level (e.g., Technology-Organization-Environment Theory and Diffusion of Innovation Theory) with each having novel propositions for future research in PI in better understanding of access and adoption of PI by individuals and across supply networks. Following our discussions of these theories, we highlight a few major topics for future research and their implications to contribute to the PI roadmap.
Isolation of Dengue Virus-Specific Memory B Cells with Live Virus Antigen from Human Subjects following Natural Infection Reveals the Presence of Diverse Novel Functional Groups of Antibody Clones
Creators: name: Crowe, J. E.
name: Kose, N.
name: Smith, S. A.
name: Jadi, R. S.
name: de Alwis, A. R.
name: de Silva, A. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Natural dengue virus (DENV) infection in humans induces antibodies (Abs) that neutralize the serotype of infection in a potent and type-specific manner; however, most Abs generated in response to infection are serotype cross-reactive and poorly neutralizing. Such cross-reactive Abs may enhance disease during subsequent infection with a virus of a different DENV serotype. Previous screening assays for DENV-specific human B cells and antibodies, using viral and recombinant antigens, mainly led to the isolation of dominant nonneutralizing B cell clones. To improve upon our ability to recover and study rare but durable and potently neutralizing DENV-specific Abs, we isolated human DENV-specific B cells by using a primary screen of binding to live virus, followed by a secondary screen with a high-throughput, flow cytometry-based neutralization assay to identify DENV-specific B cell lines prior to generation of hybridomas. Using this strategy, we identified several new classes of serotype-specific and serotype-cross-neutralizing anti-DENV monoclonal Abs (MAbs), including ultrapotent inhibitory antibodies with neutralizing activity concentrations of <10 ng/ml. We isolated serotype-specific neutralizing Abs that target diverse regions of the E protein, including epitopes present only on the intact, fully assembled viral particle. We also isolated a number of serotype-cross-neutralizing MAbs, most of which recognized a region in E protein domain I/II containing the fusion loop. These data provide insights into targets of the protective Ab-mediated immune response to natural DENV infection, which will prove valuable in the design and testing of new experimental DENV vaccines.
Tensor-Based Multi-Modality Feature Selection and Regression for Alzheimer's Disease Diagnosis
Creators: name: Yu, Jun
name: Kong, Zhaoming
name: Zhan, Liang
name: Shen, Li
name: He, Lifang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: The assessment of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) associated with brain changes remains a challenging task. Recent studies have demonstrated that combination of multi-modality imaging techniques can better reflect pathological characteristics and contribute to more accurate diagnosis of AD and MCI. In this paper, we propose a novel tensor-based multi-modality feature selection and regression method for diagnosis and biomarker identification of AD and MCI from normal controls. Specifically, we leverage the tensor structure to exploit high-level correlation information inherent in the multi-modality data, and investigate tensor-level sparsity in the multilinear regression model. We present the practical advantages of our method for the analysis of ADNI data using three imaging modalities (VBM- MRI, FDG-PET and AV45-PET) with clinical parameters of disease severity and cognitive scores. The experimental results demonstrate the superior performance of our proposed method against the state-of-the-art for the disease diagnosis and the identification of disease-specific regions and modality-related differences. The code for this work is publicly available at https://github.com/junfish/BIOS22.
Additional file 1 of Seasonal distribution and upsurge of respiratory viruses among indigenous tribes with ILI and SARI in a far-flung Car Nicobar Island
Creators: name: Muruganandam, Nagarajan
name: Vipat, Veena
name: Jadhav, Sheetal
name: Vins, Alwin
name: Beniwal, Nisha
name: Kaur, Harpreet
name: Renuka, Remya Rajan
name: Parvez, Rehnuma
name: Potdar, Varsha
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Supplementary Material 1.
Modulation of Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Function by Hypoxia-Upregulated Protein 1
Creators: name: Major, M. B.
name: Giffin, L.
name: Damania, B.
name: Yan, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these proteins is viral interleukin-6 (vIL-6), which is a homolog of human IL-6 (hIL-6). vIL-6 is able to prevent apoptosis and promote proinflammatory signaling, angiogenesis, and cell proliferation. Although it can be secreted, vIL-6 is mainly an intracellular protein that is retained in the endoplasmic reticulum (ER). We performed affinity purification and mass spectrometry to identify novel vIL-6 binding partners and found that a cellular ER chaperone, hypoxia-upregulated protein 1 (HYOU1), interacts with vIL-6. Immunohistochemical staining reveals that both PEL and KS tumor tissues express significant amounts of HYOU1. We also show that HYOU1 increases endogenous vIL-6 protein levels and that HYOU1 facilitates vIL-6-induced JAK/STAT signaling, migration, and survival in endothelial cells. Furthermore, our data suggest that HYOU1 also modulates vIL-6's ability to induce CCL2, a chemokine involved in cell migration. Finally, we investigated the impact of HYOU1 on cellular hIL-6 signaling. Collectively, our data indicate that HYOU1 is important for vIL-6 function and may play a role in the pathogenesis of KSHV-associated cancers.
Evaluation of PI boxes for last mile delivery
Creators: name: Reinthaler, Martin
name: König, Peter
name: Steinbauer, Matthias
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Physical Internet container
Last mile delivery
Pi box features
Pi pilot

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: The last mile is the most time consuming and cost intensive part of delivery processes. The handover of consignments to the customer, the associated multiple delivery attempts, unsecured depositing of consignments and the increasing problems with returns and packaging material require new approaches and solutions in the last mile. Previous work has shown the cost range of different delivery strategies for the last mile segment, were the door delivery (DoorDel) was listed as the significantly most expensive method. Furthermore, alternatives to the classic cardboard packaging are required in order to reduce packaging waste and to enable the reuse of packaging material. In contrast to reusable cardboard boxes, many more cycles can be fulfilled with transport bags and synthetic boxes.
Unresolvable human mental states based on a parallel universe theory
Creators: name: Shin, Changsoo
name: Ha, Wansoo
name: Chung, Wookeen
name: Park, Sunyoung
Publisher: name: arXiv
Year: 2014
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: We show that human mental states are unresolvable by suggesting a mathematical function that describes human mental states in relation to parallel universe theory. The function is a solution to a multi-dimensional advection equation; representing a situation a person is faced with, and its time-derivative showing the mental state in that situation. This function has interesting characteristics that explain why each person has different thoughts in a particular situation. Because the multi-dimensional advection equation has an infinite number of solutions, we can use them to represent an infinite number of mental states. We focus on the basic concepts of the model and explain the function using extremely simple cases. We also use the functions to explain remembering and forgetting.
description: 17 pages, 6 figures, 3 tables
Additional file 1 of Mobile phone handover data for measuring and analysing human population mobility in Western Ethiopia: implication for malaria disease epidemiology and elimination efforts
Creators: name: Haileselassie, Werissaw
name: Getnet, Ashagrie
name: Solomon, Hiwot
name: Deressa, Wakgari
name: Yan, Guiyun
name: Parker, Daniel M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 1: Human mobility model and analysis detail.
Low-Complexity Hybrid Precoding in Massive Multiuser MIMO Systems
Creators: name: Liang, Le
name: Xu, Wei
name: Dong, Xiaodai
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Massive multiple-input multiple-output (MIMO) is envisioned to offer considerable capacity improvement, but at the cost of high complexity of the hardware. In this paper, we propose a low-complexity hybrid precoding scheme to approach the performance of the traditional baseband zero-forcing (ZF) precoding (referred to as full-complexity ZF), which is considered a virtually optimal linear precoding scheme in massive MIMO systems. The proposed hybrid precoding scheme, named phased-ZF (PZF), essentially applies phase-only control at the RF domain and then performs a low-dimensional baseband ZF precoding based on the effective channel seen from baseband. Heavily quantized RF phase control up to $2$ bits of precision is also considered and shown to incur very limited degradation. The proposed scheme is simulated in both ideal Rayleigh fading channels and sparsely scattered millimeter wave (mmWave) channels, both achieving highly desirable performance.
description: 10 pages, 3 figures, accepted by IEEE Wireless Communications Letters
The Concept of Dynamic Smart Contracts to Enable Automated Payments in the PI
Creators: name: Spanuth, Malte
name: Franklin, Rod
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Smart contracts
Blockchain
Payments
SLAs
Contracts

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: One area of research that has not been extensively studied in the Physical Internet (PI) domain concerns how stakeholders receive payments for the services they have provided. While a payment mechanism is required for any transaction that occurs in the movement of a shipment from origin to destination (e.g., loading, unloading, load assembly, storage, etc.) we focus in this research on one type of transaction - the auctioning of a load to a carrier and the carrier’s movement of that load from one node to another node. Due to its decentralized architecture, blockchain (BC) represents a promising technology for handling this process. Thereby, smart contracts (SC) are stored on the BC. Once a previously defined event occurs, the SCs are automatically executed and release the payment. The SCs must be generated as soon as the winner of an auction has been determined and it is thus clear which carrier will transport the packet from the current to the next node. Due to the large number of different components of the auctions (including, e.g., certain country-specific regulations or handling requirements), standardized SCs cannot be created. They must be adapted each time to the parts specified in the auction. Performing this process manually would be inefficient and not feasible in the long run.
Particle Conformation Regulates Antibody Access to a Conserved GII.4 Norovirus Blockade Epitope
Creators: name: Lanzavecchia, A.
name: Lindesmith, L. C.
name: Baric, R. S.
name: Beltramello, M.
name: Jones, T. A.
name: Corti, D.
name: Swanstrom, J.
name: Pintus, S.
name: Donaldson, E. F.
name: Debbink, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: GII.4 noroviruses (NoVs) are the primary cause of epidemic viral acute gastroenteritis. One primary obstacle to successful NoV vaccination is the extensive degree of antigenic diversity among strains. The major capsid protein of GII.4 strains is evolving rapidly, resulting in the emergence of new strains with altered blockade epitopes. In addition to characterizing these evolving blockade epitopes, we have identified monoclonal antibodies (MAbs) that recognize a blockade epitope conserved across time-ordered GII.4 strains. Uniquely, the blockade potencies of MAbs that recognize the conserved GII.4 blockade epitope were temperature sensitive, suggesting that particle conformation may regulate functional access to conserved blockade non-surface-exposed epitopes. To map conformation-regulating motifs, we used bioinformatics tools to predict conserved motifs within the protruding domain of the capsid and designed mutant VLPs to test the impacts of substitutions in these motifs on antibody cross-GII.4 blockade. Charge substitutions at residues 310, 316, 484, and 493 impacted the blockade potential of cross-GII.4 blockade MAbs with minimal impact on the blockade of MAbs targeting other, separately evolving blockade epitopes. Specifically, residue 310 modulated antibody blockade temperature sensitivity in the tested strains. These data suggest access to the conserved GII.4 blockade antibody epitope is regulated by particle conformation, temperature, and amino acid residues positioned outside the antibody binding site. The regulating motif is under limited selective pressure by the host immune response and may provide a robust target for broadly reactive NoV therapeutics and protective vaccines.
The Minimal Length and the Quantum Partition Functions
Creators: name: Abbasiyan-Motlaq, M.
name: Pedram, Pouria
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the thermodynamics of various physical systems in the framework of the Generalized Uncertainty Principle that implies a minimal length uncertainty proportional to the Planck length. We present a general scheme to analytically calculate the quantum partition function of the physical systems to first order of the deformation parameter based on the behavior of the modified energy spectrum and compare our results with the classical approach. Also, we find the modified internal energy and heat capacity of the systems for the anti-Snyder framework.
description: 12 pages, to appear in Journal of Statistical Mechanics (JSTAT)
Additional file 1 of Comparison of multi-parallel quantitative real-time PCRs targeting different DNA regions and detecting soil-transmitted helminths in stool
Creators: name: Papaiakovou, Marina
name: Cimino, Rubén O.
name: Pilotte, Nils
name: Dunn, Julia
name: Littlewood, D. Timothy J.
name: Williams, Steven A.
name: Krolewiecki, Alejandro J.
name: Mejia, Rojelio
Publisher: name: figshare
Year: 2024
Subjects: Biophysics
Biochemistry
Molecular Biology
Biotechnology
Biological Sciences not elsewhere classified
Virology

description: Additional file 1.