cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Screen to Identify Novel Regulators of HIV Latency
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Acquired Immune Deficiency Syndrome (AIDS) can be controlled by antiviral drugs that prevent replication of the Human Immunodeficiency Virus (HIV) to the point where it is not detectable in blood. The interruption of drug treatment, however, is followed by the reemergence of virus. Antiviral drugs do not completely eliminate HIV from patients because the virus remains silent in a very small proportion of infected cells. This phenomenon, called latency, means that the virus escapes from the immune system and antiviral drugs. After infection of a cell, HIV produces a DNA copy of its genes that is inserted into the DNA of human cells. This inserted copy then acts as a template for the production of more viruses. During HIV latency, the inserted copy of the genome is silenced, meaning that viruses are not produced. Because viruses are not produced, neither the immune system nor antiviral drugs eliminate this silent HIV DNA. Cells with HIV DNA remain in the patient, and when antiviral drug treatment is interrupted, the silent HIV DNA becomes activated. HIV is produced, and AIDS returns. We wish to understand the mechanism of HIV DNA silencing in infected cells. If treatments that inhibit this process are developed, they can be used to activate the HIV DNA. This would result in the production of virus and the elimination of virus and infected cells by antiviral drugs and the immune system. These treatments could result in the elimination of HIV from AIDS patients to the point where it does not return. Studies of HIV have shown that once the virus inserts in DNA of human cells, it is dependent on cellular machinery for the production of more viruses. Furthermore, cellular products are likely to be responsible for repressing virus production during latency. The stage of the life cycle at which they arrest virus production is known, but the exact factors responsible for this repression and the mechanisms by which they act are largely unknown. Here, we propose experiments to identify these factors using a system developed in our laboratory that rapidly measures the reactivation of silent HIV in large numbers of cells. Importantly, this is the first time such an approach would be used to identify the mechanism of HIV repression in these cells. For this reason, we expect to identify mechanisms that have not been described before. Once the mechanism of latency has been identified in our experimental system, the results can be applied to AIDS patients. This information can be used to devise treatments that disrupt the process of latency in human beings. In combination with antiretroviral drugs, such treatments could result in the permanent elimination of HIV from patients and prevent a recurrence of AIDS.
The Role of Bromodomain Proteins in HIV Latency.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Latently infected memory T cells represent a major barrier to eradicating HIV from infected individuals, and efforts are underway to reverse HIV latency in an attempt to eradicate HIV from infected individuals. The goal of this proposal is to determine the role of the transcriptional regulators BRD2 and BRD8 in HIV latency. This approach will allow us to make rapid and significant advances in our understanding of the molecular mechanisms regulating HIV latency and to generate new treatment strategies aimed at reversing HIV latency in primary T cells.
Global Perspectives on Advance Care Planning in long-term care: Insights into Providers, Practices, and Policies. A scoping review protocol
Creators: name: Johnson, Alisha
name: Guerbaai, Raphaelle Ashley
name: Popejoy, Lori
name: Sales, Anne
name: Canada, Kelli
name: Thompson, Roy
name: Zúñiga, Franziska
name: Sperling, Edith
name: Vogelsmeier, Amy
Publisher: name: Zenodo
Year: 2024

description: The goal of this scoping review is to identify and describe how Advance Care Planning conversations are conducted in long-term care settings and to compare which healthcare provider roles, including nursing, are responsible for these activities. This review will provide an overview of which professionals are present in long-term care facilities across different countries as well as map the differences in roles and scopes of practice between countries for similar positions.
Levy, Emanuel
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Altkirch
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Zapriothrica salebrosa Wheeler 1968
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zapriothrica
Zapriothrica salebrosa

description: salebrosa Wheeler, 1968: 437. Type locality: Colombia, road to Usme and El Hato, about 1000 ft above the city of Bogotá. HT M (USNM). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
A Novel Dual Fluorescent HIV-1 to Study Latency
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: After almost 30 years of study, infection with the human immunodeficiency virus-1 (HIV-1) remains incurable. Although highly active antiretroviral therapy (HAART) suppresses HIV-1 replication, the virus persists in reservoirs of latently infected cells that avoid viral cytopathic effects and host immune clearance. Much research effort has been devoted to understanding HIV latency. However and despite much work, no drug can purge the reservoir. Moreover, many unanswered questions remain about the latent state. For example, how is latency established? How is it maintained in cells? What types of cells become latently infected? Studies to approach these questions have been complicated, partly because latently infected cells are rare in vivo. Thus, laboratory models have been used mainly to study the molecular mechanisms governing HIV-1 latency, and unfortunately, those models do not allow us to recognize cells. So latently infected cells cannot be isolated for study. To overcome these limitations, we developed a new HIV-1 virus that contains two fluorescent markers. These markers allow us to recognize cells that are latently infected, actively infected and uninfected and to isolate each subpopulation. Using this new tool, we can examine important questions that will lead to a better understanding of HIV-1 persistence, and to test/propose promising treatment for the depletion of these viral reservoirs.
Ketschenbach, J. M
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Coburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Chymomyza aldrichii Sturtevant 1920
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Chymomyza
Chymomyza aldrichii

description: aldrichii Sturtevant, 1920: 157. Type locality: Panama, Trinidad River. HT M (USNM). NT Distr.: Costa Rica to Brazil. Refs.: Grimaldi, 1987.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Role of Murr1 in HIV-1 latency
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Our immune system saves us from certain death by infection. In the absence of a working immune system, people may succumb to infections that often never occur in normal individuals. Such is the case with acquired immunodeficiency syndrome (AIDS) patients. AIDS is caused by the human immunodeficiency virus (HIV) which infects and kills a key component of the immune system, CD4 T cells. When HIV infects a CD4 T cell, it uses the host cell machinery to produce new virus which spread to other CD4 T cells while the original cell dies. To slow down HIV's inexorable assault on the immune system, a variety of drugs has been designed that interrupt different steps in the viral life cycle. Unfortunately, despite suppression of viral replication to undetectable levels through the use of combined antiretroviral therapy (ART), interruption of treatment invariably leads to a rapid rebound of virus. This rebound importantly involves virus residing in latently infected and long lived resting CD4 T cells. Latency occurs when HIV infects a cell and the viral DNA is integrated into the host DNA. But due to a loss of cellular activation, the integrated provirus may not be expressed. Since the virus in these latently infected cells is "silent" it is not vulnerable to ART, and healthy CD4 and CD8 T cells are unable to recognize these cells as HIV-infected lymphocytes. HIV eradication in infected patients will require a successful strategy for dealing with this latently infected reservoir of cells. One attractive strategy to eliminate this latent reservoir is to stimulate the expression of the silent viral genomes thereby enabling ART to act in latently infected cells. The NF-kappaB/Rel family of transcription factors represent key host factors that mediate the activation of latent HIV proviruses. We propose that these proteins have an important role in activating the latent virus. Preliminary data from our group and others suggest that, indeed, NF-kappaB related repressors are important in the maintenance of latency while transcriptionally active forms of NF-kappaB are important in the loss of latency. Recently, Murr1, a gene previously implicated in copper homeostasis, has been shown to function as a negative regulator of NF-kappaB activation. Murr1 inhibits both basal and stimulus-coupled induction of NF-kappaB by interfering with either the ubiquitylation or subsequent proteasome mediated degradaton of the NF-kappaB inhibitor, IkappaBalpha. We now propose to assess whether Murr1 plays a key role in the establishment and maintenance of HIV latency. If this proves to be the case, it could open the door to new strategies for limiting HIV latency through inhibition of the in vivo action of Murr1.
Levy, Leopold
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mulhouse
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Regulation of Foxn4 during retina development
Creators: name: Islam, Mohammed Monirul
Publisher: name: No Publisher Supplied
Year: 2012

description: Transcription factor forkhead box N4(Foxn4) is a key regulator involved in a variety of biologic processes in development and metabolism. In particular, Foxn4 plays an essential role in the genesis of amacrine and horizontal neurons from neural progenitors in the retina. Although the functions of Foxn4 have been well established, the transcriptional regulation of Foxn4 expression during progenitor cell differentiation remains unclear. The goal of this dissertation is to identify regulatory mechanisms that define the expression of Foxn4 during retinogenesis. Four evolutionarily conserved regions (CR1-CR4) from non-coding sequences of Foxn4 gene were computationally predicted as cis-elements. Their gene regulatory potential was individually tested in developing chick and mouse embryonic retina using electroporation transfection technique with a reporter assay system. In this dissertation, I describe that CR4.2 (a 129 bp DNA fragment of CR4, located approximately 50kb upstream of Foxn4 transcription start site) functions as a novel cis-regulator that directs retinal cell type specific gene expression. CR4.2 is preferentially active in the Foxn4 expressing cells, primarily in the differentiating and differentiated horizontal and amacrine cells as shown by reporter assays. Specific trans-acting factors, e.g., Meis1, were found to interact with CR4.2 by electrophoretic mobility shift assays (EMSA). Mutation and/or deletion of the Meis1 binding motif through site-directed mutagenesis diminishes the ability of CR4.2 to drive reporter GFP expression.  Furthermore, the role of Meis1 in regulating Foxn4 expression during progenitor cell differentiation was determined using a RNAi-based gene silencing assay. Knockdown of Meis1 by short hairpin RNA (shRNA) specific to Meis1 genes abolishes  gene regulatory activity of CR4.2, and further diminishes the endogenous level of Foxn4 expression. In addition, cells with Meis1 knockdown failed to differentiate into horizontal cells. Taken together, I demonstrate that Meis1 transcription factor regulate the expression of Foxn4 expression and horizontal cell lineage development in the vertebrate retina via their interactions with CR4.2. These findings provide new insights into molecular mechanisms that govern gene regulation in retinal progenitors and vertebrate retinal cell development.
Role of Cyclin T1 acetylation in HIV transcription
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The HIV Tat protein is a multifunctional regulatory viral protein, expressed early after HIV infection. Tat acts as the viral transactivator and is critical for the generation of viral messenger RNAs. Tat binds to TAR RNA and cyclin T1, an important regulatory component of the positive transcription elongation factor b (P-TEFb). Cyclin T1 in complex with Tat also makes contact with loop sequences in TAR and recruits the kinase activity of CDK9 to the HIV promoter. CDK9 recruited by the Tat/TAR/cyclin T1 complex phosphorylates the C-terminal domain of the RNA polymerase II complex (RNAPII) and enhances the processivity of RNAPII to produce fully enlongated HIV transcripts. The interaction of Tat, TAR RNA and cyclin T1 is regulated through acetylation of Tat by the acetyltransferase p300. Acetylation of Tat enhances Tat transactivation by dissociating cyclin T1 from TAR RNA and transferring Tat directly to the elongating RNAPII. Acetylated Tat provides a novel protein:protein interface with the transcriptional coactivator PCAF via the PCAF bromodomain. Interestingly, the activity of P-TEFb is also regulated via RNA interaction. About 50% of cellular P-TEFb consists of the cyclin T1/CDK9 heterodimer complexed with 7SK small nuclear RNA and Hexim 1. This complex is catalytically inactive. Upon treatment with several stress-inducing agents 7SK RNA and Hexim 1 are dissociated from cyclin T1/CDK9 and CDK9 becomes enzymatically active. We were intrigued by the similarities between the Tat/TAR/cyclin T1 and the large P-TEFb complex. We speculated that acetylation of a P-TEFb component could also lead to the dissociation of the cyclin T1/7SK RNA/Hexim 1 complex. We report here that cyclin T1 is acetylated by p300. Cyclin T1 acetylation dissociates cyclin T1 from Hexim 1 and activates P-TEFb transcriptional activity. We propose to further characterize the effect of cyclin T1 acetylation in P-TEFb biologgy and HIV infection. We will generate specific antibodies directed against acetylated cyclin T1 and study the association of endogenous cyclin T1 with large and small P-TEFb complexes. We will also perform chromatin immunoprecipitation experiments to determine whether acetylated cyclin T1 associates with the HIV promoter in vivo. Since cyclin T1 binds cooperatively with Tat to TAR RNA, we will analyze whether cyclin T1 acetylation regulates this association in RNA gelshift experiments. In addition, we will examine the effect of an acetylation-deficient mutant of cyclin T1 on Tat transactivation and HIV-1 replication. We anticipate that these studies will demonstrate that cyclin T1 acetylation plays an important role in P-TEFb biology and HIV infection.
Knörr, Friedrich & Sohn
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Luzern
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Lex, Felix J., Notar
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Kindervater, Gebrüder
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Ulm
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Drosophila bilineata Williston 1896
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila bilineata

description: bilineata (Williston), 1896: 409 (Drosophila). Type locality: St. Vincent and the Granadines. LT A (BMNH). NT Distr.: Brazil, Colombia, Costa Rica, West Indies. Refs.: Grimaldi, 1987.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Koechlin, R. & E
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mulhouse
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Caridina H. Milne Edwards 1837
Creators: name: Tu, Do Van
name: Thu, Cao Thi Kim
name: Rintelen, Thomas Von
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Atyidae
Caridina

description: Genus Caridina H. Milne Edwards, 1837
Type species. Caridina typus H. Milne Edwards, 1837, by original designation
Caridina thachlam, sp. nov.
(Figs. 2–5)
Examined material. Holotype: 1 male, cl 4.2 mm, Vietnam, Thanh Hoa Province, Thach Thanh District, Thach Lam Commune, Bo Village, N 20°21’24.0779” E 105°30’27.347” (cave 1, lower), IEBR–FS–004, 10.v.2019, Do VT, Hoang AT & Dang VD. Paratypes: 4 females, cl 3.5–4.5 mm; 2 males, cl 4.2 mm, ZMB 30337, same data as holotype; 1 female, cl 4.2 mm; 2 males, cl 3.7–4.2 mm, Vietnam, Thanh Hoa, Thach Thanh, Thach Lam, Bo, (cave 2, higher, site 2), N 20°21’8.214” E 105°31’8.681”, ZMB 300337, 10.v.2019, Do VT, Dang VD. 5 females, cl 4.3–4.8 mm; 1 male, cl 4.5 mm, Vietnam, Thanh Hoa, Thach Thanh, Thach Lam, Bo, (cave 2, higher, site 1), N 20°21’8.214” E 105°31’8.681”, ZMB 31773, 10.v.2019, Do VT, Dang VD.; 2 males, cl 3.2–3.8 mm; 6 females (incl. one ovigerous), cl 3.0– 4.6 mm, Vietnam, Ninh Binh, Nho Quan, Cuc Phuong, Dang, N 20°16’59.5” E 105°40’37.2”, ZMB 31781, 9.v.2019, von Rintelen T, Do VT, Hoang AT, Dang VD. All caves are located in Cuc Phuong National Park.
Comparative material. Caridina clinata Cai, Nguyen & Ng, 1999: male, cl 3.1 mm, Vietnam, Ninh Binh, a small stream in Cuc Phuong National Park, N 20°19’11.118’’ E 105°37’42.168’’, ZMB 30664, von Rintelen T & Do VT, 3.iv.2017. Caridina cucphuongensis Dang in Dang, Thai & Pham, 1980: male, cl 3.8 mm; 2 females, cl 4.2–4.4 mm, Vietnam, Ninh Binh, Cuc Phuong National Park, a small stream near the foot path to the one thousand year old tree (Vietnamese name: chò), N 20°21’0.779’’ E 105°36’11.675’’, ZMB 30234, von Rintelen T, Do VT, 03.iv.2017.
description: Published as part of Tu, Do Van, Thu, Cao Thi Kim & Rintelen, Thomas Von, 2021, Deep into darkness: the first stygobitic species of freshwater shrimp of the genus Caridina (Crustacea: Decapoda: Atyidae) from Northern Vietnam, pp. 422-434 in Zootaxa 4933 (3) on page 425, DOI: 10.11646/zootaxa.4933.3.8, http://zenodo.org/record/4555104
Falcini, Balthasar
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Luzern
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Update KiR: An Evidence-Based Program Reducing Teen Tobacco & Cannabis Use
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: keepin’ it REAL (KiR) is an effective, multicultural middle school drug prevention program that has been shown to reduce tobacco marijuana, and alcohol use. KiR teaches youth to think critically and communicate effectively. The lessons cover risk assessment, decision making, and communication skills such as tobacco, marijuana and other substance refusal. REAL refers to the resistance strategies - Refuse, Explain, Avoid, and Leave - that teens can use to negotiate tobacco, marijuana and other substance offers. These strategies are based on narratives from thousands of adolescents describing their lives and experiences with cigarettes, marijuana, and other substances. The multimedia, culturally grounded middle school prevention program consists of ten school lessons and five videos developed by kids for kids. This is followed by “boosters” that reinforce the program. The KiR curriculum has been evaluated with thousands of middle school children and has been shown to be effective in reducing adolescent tobacco, marijuana and other drug use. The curriculum was published in 2005, and has not been updated since. This project is focused on updating and modernizing all pieces of the KiR curriculum. ETR will work closely with Dr. Flavio Marsiglia, the original developer, and the health innovation company, dfusion, to conduct formative evaluation activities to drive the curriculum updates and modernization. The team will ground the work in the core components of the curriculum while considering strategies to update the “youth stories,” create new video and other media, and consider new delivery modes for sections of the lessons. The updated curriculum will include the most current content related to electronic nicotine delivery systems (ENDS), cannabis, and second hand smoke. It will be piloted in 2-3 sites and fine-tuned accordingly.
Revised Application:Underreported Anal Sex in Women
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV infectivity during anal sex is more efficient than vaginal transmission yet heterosexual receptive anal intercourse (HRAI) in women is poorly understood. The practice of HRAI occurs within different contexts and alcohol and drugs may have mediating effects on HRAI. Previous research indicates that anywhere from 8 percent to 39 percent of heterosexuals reported HRAI in the past year. However, research is lacking on the HIV risks associated with frequent acts of HRAI among heterosexual women, as well as the epidemiology of predictors of HRAI. One study of clients of sexually transmitted disease clinics noted that proportions of individuals reporting HRAI appear to be increasing over time. Predictors of frequent receptive anal intercourse in men who have sex with men are fairly well researched, but the same cannot be said for women. This proposed research attempts to assess women’s understandings of anal sex using qualitative methods; and to use electronic diaries using smart telephones to gather event level data on occurrences of anal sex in two, non-equivalent groups: drug-using women who have previously reported receptive anal sex with a male partner, and drug-using women who have not previously reported receptive anal sex. Women will be recruited from an existing database of current clients of the Center for Behavioral Research and Services (CBRS) of women who have previously unprotected anal sex. A small number of key-informant women will be invited to participate in focus groups and unstructured interviews concerning their understanding of receptive anal sex. Data from these focus groups and unstructured interviews will inform the questions deployed via smart telephone for a sexual-event diary study. Diary information will be collected longitudinally for 12-weeks following procedures developed by Fortenberry, et al.
GesundFDM User Stories - Bedarfe und Lösungsansätze
Creators: name: Schuckmann, Katharina
Publisher: name: Zenodo
Year: 2024
Subjects: FDM@HAW
FDM
Forschungsdatenmanagement
Hochschule für angewandte Wissenschaften
Fachhochschule
HAW
FH
Datenkompetenzen
FDM-Kompetenzen an HAW 2024

description: Das Poster illustriert, wie im vom BMBF-geförderten Projekt GesundFDM die Bedarfe von Forschenden in den gesundheits- und pflegebezogenen Wissenschaften erhoben und weiterverarbeitet wurden. Dafür wurden zunächst 34 leitfadengestützte, qualitative Interviews geführt, welche in der Folge transkribiert wurden. Anschließend wurden die Antworten mittels eines eigens entwickelten Kodiersystems entsprechenden Kategorien zugeordnet. Daraus wurden dann prototypische User Stories im Format "Ich bin...", "Ich möchte...", "Ich brauche..." abgeleitet. In einem letzten Schritt, wurden den geäußerten Bedarfe der Forschenden entsprechende Lösungsansätze zugeordnet.

Dieses Poster wurde im Rahmen der VW-Themenwoche "Digitale Kompetenzen in der Wissenschaft" im Workshop "FDM mit geringen Ressourcen. Kompetenzaufbau durch Vernetzung von Hochschulen für angewandte Wissenschaften" am 02. Dezember 2024 vorgestellt.
Loeffler & Klentz
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Neapel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Löw, Hans Jacob
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Benken BL
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Local Cannabis Regulation: What have we learned from tobacco
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In 2018, adult-use cannabis sales became legal in California, joining 6 other states. It is hoped that this policy will reduce drug related mass incarceration and violence, bringing a large-scale, clandestine industry into the light. Yet cannabis use is associated with significant harms, especially when use commences young, is more frequent, or occurs during pregnancy. Products known from tobacco and alcohol research to attract youth are being sold, from orange soda to bubble-gum flavored pre-rolls to strawberry lollipops. Prices are declining and potency rising. Increasing use may place progress in social and legal norms for smoking and tobacco at risk.

 We face the challenge of creating a regulatory system to optimize benefits of legalization while minimizing harm, including preventing youth and other high risk exposure. While the statewide policy framework is weak in public health protection, Prop 64 left broad leeway to local government to regulate or ban. In 2017, we carried out qualitative research with experts and stakeholders on a broad range of issues to identify optimal policy elements, in a setting of uncertainty. We then formulated model local ordinances for cannabis retailing, marketing and taxation, incorporating lessons learned from decades of tobacco and alcohol regulation. Yet, little is known about what practices are actually being adopted at the local level.

 For this reason, we propose a pilot study of the content of local law on adult-use cannabis in California’s 58 counties and 482 cities in 2018-2019. Using the CannaRegs database, which tracks local law on this issue, complemented by direct consultations, we will examine how CA jurisdictions are regulating cannabis in areas covered by our models including: smoke-free air and interaction with existing tobacco law, allowable density of retailers, equity for low income residents, product types and potency allowed (including flavors and attractiveness to youth), marketing, warnings to the public, claims, discounting, taxation design, and use of tax revenue. Results will be analyzed, published, and used to inform policymakers and engage communities on current local practice, extent of adoption of policies to protect health, and areas for improvement. This knowledge is an essential substrate for future research to understand health impact of legalization and identify best practices.
Koechlin, André & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mulhouse
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Low, Wilson
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: New York
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Kühn & Boiteux
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Rio de Janeiro
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Structure-based recombination of HIV neutralizing antibodies
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: HIV/AIDS remains one of the most important current threats to global public health. At least 60 million people have been infected with HIV, of which almost half have died. Although anti-HIV drugs have been effective among the wealthiest populations, a vaccine and/or new methods to prevent infections are drastically needed, especially in underrepresented and marginalized populations in the both the United States and the developing world. Evidence shows that delivery of antibodies, the Y-shaped proteins produced by the immune system to recognize and neutralize foreign objects in our bodies, is a safe and effective strategy used to treat many diseases. We will attempt to make new and improved antibodies that may be used to treat and/or prevent HIV infections. Starting with a novel class of antibodies that effectively neutralizes several strains of HIV using the same mechanism, we will use a synthetic biology approach to break several effective antibodies (parents) into smaller pieces and recombine the pieces from different parents to make a library of mixed antibodies that will be tested for enhanced ability to prevent HIV infection. One may think of each antibody as being a different color, whose structure is an ordered series of beads of a particular shape on a string (for instance, parent 1 could comprise a cube, sphere, pyramid, cone, and cylinder, all in red). We plan to preserve the order of the beads to produce the same shape in all chimeras, but vary the color to make thousands of different colored necklaces (i.e. bead 1 will always be a cube, but it could be blue, red, green, or any color of an available parent antibodies; it will always be followed by a sphere of any available color, etc.). Each shuffled antibody, represented by a necklace of different colored beads, could then be tested for its ability to prevent HIV infection. This method has been proven to work to improve proteins for use in industrial applications. After successful antibodies have been identified, we will analyze them to determine how the antibodies interact with viral proteins at the atomic level. We will use crystallography, in which we take a mixture of the antibody and the HIV protein that interacts and put it in solution and let it dry slowly, so that it can form an ordered crystal, in the same manner as one might make rock candy. We will then examine the crystal using the x-ray equivalent of a light microscope to look at the position of atoms in our crystals. This analysis will allow us to understand the atomic features that are important and necessary for interactions between antibodies and HIV surface proteins and prevention of HIV infection. Through our studies, we hope to make novel antibodies and uncover new information that can be used to further devise strategies to treat and/or prevent HIV infection.
Reexamining a community
Creators: name: Holden, Vanessa Michele
Publisher: name: No Publisher Supplied
Year: 2012

description: The Southampton Rebellion (Nat Turner's Rebellion) erupted in Southampton County, Virginia, in the late summer of 1831. The death of nearly sixty whites at the hands of slave rebels shook Old Dominion to its foundation and left a nation in shock. The historiography concerned with the rebellion focuses largely on the character of the rebellion’s purported leader, Nat Turner, and the larger political impact that the rebellion’s outbreak had on both Virginia and the United Sates. But what would a focus on enslaved women do to our understanding of America's most famous slave rebellion? This dissertation explores the ways that African American women's lives and experiences provide a unique vantage point from which to interrogate the African American community's longstanding culture of resistance and the labor economy that shaped all of the lives of those who resided in the county. Attending to African American women's lives allows for a narrative of the rebellion not as the history of one great man and his vision but, rather, as a narrative of a site of resistance produced by an entire community of African Americans.
Examining the Role that Social Abjection and Stigma Play in Prohibiting Female Re-Acceptance into Minority Cultures Post Wartime-Rape
Creators: name: Shankar, Ashleigh
Publisher: name: Macquarie University
Year: 2024
Subjects: classificationCode: 440209
subject: Gender and crime

description: Throughout the history of warfare, rape and other forms of sexual violence against women in particular have even extremely widespread and prolific (Henry, 2016). However, despite legal interventions and feminist critiques, rape in war has endured as a lasting legacy of violent conflict that has almost exclusively been perpetrated against women (Henry, 2016). Through this overarching perspective, this thesis aims to understand the mechanisms contributing to women remaining conspicuous victims of sexual violence. The focus on gender, is therefore crucial to the way in which the war environment is understood as contemporary literature highlights that wartime is fuelled by clear, hierarchal distinctions between masculinity and femininity. These distinctions emphasise female subordination to men and reinforce their lower social standings, allowing male perpetrators to assert physical and sexual dominance upon their victims. The result of such rigid, underlying structures of gendered, psychic formation is that female bodies are frequently targeted through sexual violence through varying techniques. For example, mass rapes and gang rapes at the hands of male combatants, often through oral, anal and vaginal penetration. In this context, wartime rape cannot be viewed as a ‘regrettable’ side effect and an ‘inevitable’ product of war, predicated on natural male virility, heterosexuality and domination. Rather, wartime rape showcases through an elevated lens the traditional, masculine, and by extension, hegemonic desire to asset power, dominance and control on an extremis scale.
Drawing on these debates, this project undertakes a critical discourse analysis of a witness statement given to the International Criminal Tribunal for Yugoslavia of a rape victim and survivor during the Bosnian War. In doing so, this thesis examines the roles and impact of stigmatising rituals that arise as a consequence of social objection, which ultimately shapes the experiences of rape victims in times of conflict.
Langensée, Carl
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Neapel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Ludendorff, J. H. & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Hamburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Zygothrica circumveha Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica circumveha

description: circumveha Grimaldi, 1987: 175. Type locality: Mexico, Sinaloa, 14 mi W El Palmito, 5000 ft. HT M (CNC). NT Distr.: Mexico (Sinaloa).
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Kummler-Hartmann
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Arlesheim BL
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
ELECTROCHEMICAL ANALYSIS of DNMT1 and miRNA AS BIOMARKERS OF LUNG CANCER
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The worldwide tobacco problem is immense. Smoking causes 30% of all cancer deaths, including nearly 90% of deaths from lung cancer. The poor survival is largely due to the lack of early screenable biomarkers, which leads to detection of the cancer at an advanced and typically untreatable stage. A diagnostic method that can simultaneously detect DNA and miRNA cancer biomarkers may offer a sensitive and selective detection of tobacco related lung cancer for early prevention and treatment. A multitude of biomarkers have been connected to tumorogenesis, yet abnormal DNA methyltransferase activity and specific miRNA biomarkers are often linked to the development and progression of lung cancer. Here, I will describe an electrochemical biosensor that can detect a DNA methyltransferase biomarker and a miRNA biomarker at the early stage of tobacco use related lung cancer. The low-cost, easy-to-use, highly sensitive and selective biosensor shows great potential as early diagnostic tool for lung cancer.
Lays
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Guebwiller
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Zygothrica florinjecta Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica florinjecta

description: florinjecta Grimaldi, 1987: 162. Type locality: Colombia, 25 km W Bogotá. HT M (AMNH). NT Distr.: Colombia. Grimaldi, 1990: 97.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Lendenmann & Buchy
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Lyon
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Engineering Immunity against HIV - a Stem Cell Vaccine
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: An effective vaccine against the human immunodeficiency virus (HIV)-1, the causative agent of AIDS, has so far been elusive. Vaccines against other viruses work by stimulating the production of antibodies that block infection, called neutralizing antibodies. Traditional vaccines typically use an immunogen to stimulate the body's own immune system to make neutralizing antibodies. However, due to the diversity of HIV variants and the rapid rate at which HIV mutates, among other reasons, it has been exceedingly difficult to design a vaccine immunogen that is able to stimulate an antibody response of the quality and breadth required to cover all the variants of HIV. However, scientists have discovered rare broadly cross-reactive antibodies in patients who are long-term non-progressors (people who remained disease free without treatment for more than 10 years after HIV infection). These rare antibodies, called broadly neutralizing antibody, or bNAbs for short, are able to neutralize diverse HIV variants. bNAbs have been shown to protective against HIV infections in past experiments. Thus if a method to deliver these bNAbs to people long-term can be developed, there is hope that we will have an effecitive vaccine against HIV. The genes that produce some of the bNAbs have been isolated. With the help of gene therapy technology, it is now possible to directly program the immune system to make such antibodies, perhaps without the need for an immunogen. This is the approach we are pursuing in this study. We will take the hematopoietic stem cells ("HSCs"), a population of long-lived cells in the body that makes the immune cells that produce antibodies, and insert into them the genes that make the bNAbs. When these HSCs develop into mature immune cells in the receipients, they should gain the ability to make the same bNAbs programmed by the genes for life, and be protected from HIV infection. We have developed a novel technique to program cells with bNAb genes. Using this technique, we will test the feasibility of the gene therapy approach first in a tissue-culture model of immune cell development, and then in a mouse model of HIV infection. Because HIV is a human virus and will only infect human cells, the mice are specially engineered to make human immune cells. While the mice are not expected to suffer any ill effects due to the HIV infection, because HIV will only affect the human cells, by looking at the responses of the human cells in these mice, we can get a good idea of how well this "stem cell vaccine" will work in people. This work will provide valuable insights into how we can make an effective vaccine against HIV, and pave the way for a clinically testable prototype HIV "stem cell vaccine."
Lévêque, Michel
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: St Louis
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Favarger, C. F. L
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: St Thomas / New York
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Loeffler & Desgrands
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Messina
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Forcarde
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Havanna
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Zygothrica fuscalata Grimaldi 1987
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zygothrica
Zygothrica fuscalata

description: fuscalata Grimaldi, 1987: 152. Type locality: Peru, Tingo Maria. HT M (AMNH). NT Distr.: Colombia, Peru.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 738, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Fellinger & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Neapel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert