cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Simultaneous integrated boost therapy of carcinoma of the hypopharynx/larynx with and without flattening filter - a treatment planning and dosimetry study
Creators: name: Dobler, Barbara
name: Obermeier, Tina
name: Hautmann, Matthias G.
name: Khemissi, Amine
name: Koelbl, Oliver
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: MODULATED ARC THERAPY; STEREOTACTIC BODY RADIOTHERAPY; SQUAMOUS-CELL CARCINOMA; SIDED BREAST-CANCER; FREE BEAMS; RADIATION-THERAPY; NASOPHARYNGEAL CARCINOMA; NECK-CANCER; HEAD; IMRT; Hypopharynx carcinoma; Larynx carcinoma; Simultaneous integrated boost; Flattening filter free; Peripheral dose; Radiation induced second cancer
subject: 610 Medizin

description: Background: The aim of this study was to investigate if the flattening filter free (FFF) irradiation mode of a linear accelerator (linac) is advantageous as compared to the flat beam (FF) irradiation mode in intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) for carcinoma of the hypopharynx/larynx. Methods: Four treatment plans were created for each of 10 patients for an Elekta Synergy linac with Agility collimating device, a dual arc VMAT and a nine field step and shoot IMRT each with and without flattening filter. Plan quality was compared considering target coverage and dose to the organs at risk. All plans were verified by a 2D-ionization-chamber-array and delivery times were compared. Peripheral point doses were determined as a measure of second cancer risk. The Wilcoxon test was used for statistical analysis with a significance level of 0.05. Results: Plan quality was similar for all four treatment plans without statistically significant differences of clinical relevance. The clinical goals were met in all plans for the PTV-SIB (V-95% > 95%), the spinal cord (D1ccm < 45 Gy) and the brain stem (D-1ccm < 48 Gy). For the parotids, the goal of D-50% < 30 Gy was met in 70% and 60% of the plans for the left and right parotid respectively, and the V-95% of the SIB reached an average of 94%. Delivery times were similar for FF and FFF and significantly decreased by around 70% for VMAT as compared to IMRT. Peripheral doses were significantly reduced by 18% in FFF mode as compared to FF and by 26% for VMAT as compared to IMRT. Lowest peripheral doses were found for VMAT FFF, followed by VMAT FF. Conclusions: The FFF mode of a linear accelerator is advantageous for the treatment of hypopharynx/ larynx carcinoma only with respect to reduction of second cancer induction in peripheral organs for the combination of Elekta Synergy linacs and Oncentra (R) External Beam v4.5 treatment planning system. This might be of interest in a therapy with curative intent.
Bsteh, Irmgard: Perlen brauchen Körperwärme
Creators: name: Grunert, E.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Eysenck, Hans J. / Sargent, Carl: Der übersinnliche Mensch
Creators: name: Ditzer, K.H.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing
Creators: name: Lin, Dasheng
name: Alberton, Paolo
name: Caceres, Manuel Delgado
name: Volkmer, Elias
name: Schieker, Matthias
name: Docheva, Denitsa
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: ROTATOR CUFF REPAIR; STEM/PROGENITOR CELLS; CHONDROMODULIN-I; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; SELF-RENEWAL; PPAR-GAMMA; MOLECULAR-CLONING; ADIPOSE-TISSUE; FIBROSIS;
subject: 610 Medizin

description: Tenomodulin (Tnmd) is the best-known mature marker for tendon and ligament lineage cells. It is important for tendon maturation, running performance and has key implications for the resident tendon stem/progenitor cells (TSPCs). However, its exact functions during the tendon repair process still remain elusive. Here, we established an Achilles tendon injury model in a Tnmd knockout (Tnmd(-/-)) mouse line. Detailed analyses showed not only a very different scar organization with a clearly reduced cell proliferation and expression of certain tendon-related genes, but also increased cell apoptosis, adipocyte and blood vessel accumulation in the early phase of tendon healing compared with their wild-type (WT) littermates. In addition, Tnmd(-/-) tendon scar tissue contained augmented matrix deposition of biglycan, cartilage oligomeric matrix protein (Comp) and fibronectin, altered macrophage profile and reduced numbers of CD146-positive cells. In vitro analysis revealed that Tnmd(-/-) TSPCs exhibited significantly reduced migration and proliferation potential compared with that of WT TSPCs. Furthermore, Tnmd(-/-) TSPCs had accelerated adipogenic differentiation accompanied with significantly increased peroxisome proliferator-activated receptor gamma (Ppar gamma) and lipoprotein lipase (Lpl) mRNA levels. Thus, our results demonstrate that Tnmd is required for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing.
Paired Associative Stimulation of the Temporal Cortex: Effects on the Auditory Steady-State Response
Creators: name: Engel, Sarah
name: Markewitz, Robert Daniel Heinrich
name: Langguth, Berthold
name: Schecklmann, Martin
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; TINNITUS; DECONVOLUTION; PLASTICITY; THRESHOLD; FIELDS; paired associative stimulation; auditory steady-state response; temporal cortex; tinnitus; spike-timing dependent plasticity
subject: 610 Medizin

description: Background: Paired associative stimulation (PAS) is the repeated combination of a sensory stimulus with transcranial magnetic stimulation (TMS) in close temporal association. Recently, a study demonstrated that PAS of an auditory stimulus together with TMS of the temporal cortex is capable of changing the amplitude of auditory evoked potentials (AEP). Objective: This study examined the influence of tone duration and habituation in temporal cortex PAS as elicited by 40 and 20 Hz amplitude modulated auditory steady-state responses (aSSR). Methods: Eighteen subjects participated in two experiments, including two PAS protocols each, which consisted of 200 auditory stimuli (4 kHz) paired with temporal cortex TMS with an interstimulus interval (ISI) of 45 ms between tone onset and TMS pulse, delivered at 0.1 Hz. Experiment 1 compared auditory stimuli with different lengths [PAS (23 ms) vs. PAS (400 ms)]. Experiment 2 investigated verum vs. sham PAS. aSSR for the paired tone (4 kHz) and a control tone (1 kHz) were measured pre- and post-interventional-using 40 Hz aSSR in experiment 1 and both 20 and 40 Hz aSSR in experiment 2. Results: A statistically significant, sham-controlled decrease in amplitude was observed for the 20 Hz aSSR using the 4 kHz PAS carrier frequency in experiment 2. Conclusion: Frequency-specific effects for the 20 Hz aSSR confirm the feasibility of auditory PAS and highlight the secondary auditory cortex as its target site, introducing new possible treatment protocols for patients suffering from tinnitus. The amplitude decrease can be explained by principles of spike timing-dependent plasticity and the superposition model of aSSR.
Trocnadella arisana Matsumura
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Trocnadella
Trocnadella arisana

description: Trocnadella arisana (Matsumura)
Macropsis arisana Matsumura, 1912:299 Bythoscopus arisanus: Esaki and Ito, 1954 Iassus arisanus: Metcalf, 1966:45
Trocnadella arisana (Matsumura) Viraktamath, 1979: 105, figs. 53–65 Distribution. China (Taiwan).
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on page 35, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
Video Tutorial for Clinical Flap-Monitoring in Plastic Surgery
Creators: name: Schiltz, Daniel
name: Geis, Sebastian
name: Kehrer, Andreas
name: Dolderer, Jürgen
name: Prantl, Lukas
name: Taeger, Christian D.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: 610 Medizin

description: Free tissue transfer is a well-established technique in the field of plastic reconstructive surgery. Despite great progress being made in relation to technical issues and the anatomical understanding of free flap transfers, a loss rate of between 2% and 5% remains.1–5 The main reasons for free flap failure are vascular problems, such as vascular thrombosis (venous and arterial), arterial insufficiency, active bleeding or hematoma, and venous congestion.1–4 Many studies have demonstrated that the salvage rate for flaps is inversely related to the time between the onset of vascular compromise and surgical intervention.6,7 To guarantee an immediate reaction in case of perfusion problems in free flap surgery, a continuous and sufficient flap monitoring is indispensable. Although there are numerous techniques to assess flap vitality, clinical examination remains the gold standard.8 Besides this preferred method, a handheld and implantable Doppler, microdialysis, video-based application, real-time measurement of oxygen saturation, fluorescence angiography, spectroscopy, contrast-enhanced duplex, and activated clotting time have been proposed as alternative modalities for monitoring, though none of these has provided better results than clinical examination.9,10

The postoperative clinical examination and monitoring of flaps is frequently delegated to nurses and paramedics. Thus, there is often a high variation in skill level due to the lack of clinical experience needed to assess flap vitality.11 When asked, even young plastic surgeons often admit uncertainty when it comes to assessing postoperative flap vitality. To guarantee a high level of monitoring quality, constant training is indispensable. As mentioned above, perfusion compromise—being of arterial or venous origin—emerges rarely and is hard to include consistently within a training program. Therefore, educational material that clearly elucidates different qualities in vascular compromise in flaps is highly desirable.
Measuring critical transitions in financial markets
Creators: name: Jurczyk, Jan
name: Rehberg, Thorsten
name: Eckrot, Alexander
name: Morgenstern, Ingo
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: RANDOM-MATRIX THEORY; PORTFOLIO OPTIMIZATION; LOGISTIC-REGRESSION; SYSTEMIC RISK; TIME-SERIES; MODEL;
subject: 530 Physik
subject: 610 Medizin

description: Tipping points in complex systems are structural transitions from one state to another. In financial markets these critical points are connected to systemic risks, which have led to financial crisis in the past. Due to this, researchers are studying tipping points with different methods. This paper introduces a new method which bridges the gap between real-world portfolio management and statistical facts in financial markets in order to give more insight into the mechanics of financial markets.
Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases
Creators: name: Schmid, Peter M.
name: Bouazzaoui, Karin
name: Schmid, Karin
name: Birner, Christoph
name: Schach, Christian
name: Maier, Lars S.
name: Holler, Ernst
name: Endemann, Dierk H.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: STEM-CELL TRANSPLANTATION; ACUTE KIDNEY INJURY; REGULATORY T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE GENE; IFN-GAMMA; NEPHROTIC SYNDROME; INTERFERON-GAMMA; SERUM-LEVELS; EXPRESSION; GVHD; renal GvHD; cytokines; IDO; apoptosis; urinary NAG
subject: 610 Medizin

description: Acute kidney injury (AKI) is a very common complication after allogeneic bone marrow transplantation (BMT) and is associated with a poor prognosis. Generally, the kidneys are assumed to not be no direct targets of graft-versus-host disease (GvHD), and renal impairment is often attributed to several other factors occurring in the early phase after BMT. Our study aimed to prove the existence of renal GvHD in a fully major histocompatibility complex (MHC)-mismatched model of BALB/c mice conditioned and transplanted according to 2 different intensity protocols. Syngeneically transplanted and untreated animals served as controls. Four weeks after transplantation, allogeneic animals developed acute GvHD that was more pronounced in the high-intensity protocol (HIP) group than in the low-intensity protocol (LIP) group. Urea and creatinine as classic serum markers of renal function could not verify renal impairment 4 weeks after BMT. Creatinine levels were even reduced as a result of catabolic metabolism and loss of muscle mass due to acute GvHD. Proteinuria, albuminuria, and urinary N-acetyl-beta-D-glucosaminidase (NAG) levels were measured as additional renal markers before and after transplantation. Albuminuria and NAG were only significantly increased after allogeneic transplantation, correlating with disease severity between HIP and LIP animals. Histological investigations of the kidneys showed renal infiltration of T cells and macrophages with endarteriitis, interstitial nephritis, tubulitis, and glomerulitis. T cells consisted of CD4+, CD8+, and FoxP3+ cells. Renal expression analysis of allogeneic animals showed increases in indoleamine-2,3 dioxygenase (IDO), different cytokines (tumor necrosis factor alpha, interferon-gamma, interleukin 1 alpha [IL-1 alpha], IL-2, IL-6, and IL-10), and adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1), resembling findings from other tissues in acute GvHD. In summary, our study supports the entity of renal GvHD with histological features suggestive of cellmediated renal injury. Albuminuria and urinary NAG levels may serve as early markers of renal impairment.
Macrothrix paulensis
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Macrothricidae
Macrothrix
Macrothrix paulensis

description: Macrothrix paulensis (Sars,1900).
(1) Capivara Pond, Arembepe, Camaçari, 12°45’42”S 38°10’08”W, 12.vii.2002, coll. L.M.A. Elmoor-Loureiro (EL00374). (2) Formoso River, pond 2, Trijunção Farm, Cocos, 14°47’18”S 45°56’42”W, 27.iv.2003, coll. L.M.A. Elmoor-Loureiro (EL00341).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 21, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Stable Discontinuous Galerkin Spectral Element Methods for Higher Order Wave Equations
Creators: name: Wiratama, Kenny
Publisher: name: The Australian National University
Year: 2024

description: In this thesis, we focus on discontinuous Galerkin spectral element methods (DGSEMs), which have recently gained considerable interest due to their high order accuracy and scalability. In particular, we discuss the development of a DGSEM spatial discretization framework that satisfies the summation-by-parts property. This property is the discrete analogue of the continuous integration-by-parts property, and it plays a crucial role in achieving numerical stability. Based on this approach, we develop provably stable DGSEMs for three higher order wave equations, namely the shifted wave equation, the Camassa-Holm equation, and the Serre equations. For each of these equations, we start by analyzing well-posed boundary conditions in a bounded domain using the energy method. The boundary conditions yield energy stable initial boundary value problems, facilitating the design of robust and arbitrarily accurate numerical methods. We propose provably stable DGSEMs to obtain the numerical solutions of the initial boundary value problems. The stability of our numerical approximations is rigorously proved by deriving discrete energy estimates mimicking the continuous energy estimates. Numerical experiments are presented to verify the theoretical results.
Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1
Creators: name: Malsy, Manuela
name: Graf, Bernhard
name: Bundscherer, Anika
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GEMCITABINE PLUS CELECOXIB; PHASE-II TRIAL; DUCTAL ADENOCARCINOMA; CYCLOOXYGENASE-2 EXPRESSION; THROMBOEMBOLIC DISEASE; CARCINOMA CELLS; TUMOR-GROWTH; IN-VITRO; DIPYRONE; Metamizole; Dipyrone; MAA; Paracetamol; Acetaminophen; Pancreatic carcinoma; Cancer; Proliferation; Apoptosis; Necrosis
subject: 610 Medizin

description: Background: Adenocarcinoma of the pancreas is one of the most aggressive cancer diseases affecting the human body. Recent research has shown the importance of the perioperative phase in disease progression. Particularly during this vulnerable phase, substances such as metamizole and paracetamol are given as general anesthetics and postoperative analgesics. Therefore, the effects of metamizole and paracetamol on tumor progression should be investigated in more detail because the extent to which these substances influence the carcinogenesis of pancreatic carcinoma is still unclear. This study analyzed the influence of metamizole and its active metabolites MAA (4-N-methyl-aminoantipyrine) and paracetamol on the proliferation, apoptosis, and necrosis of the pancreatic cancer cell lines PaTu 8988t and Panc-1 in vitro. Methods: Cell proliferation was measured by means of the ELISA BrdU assay and the rate of apoptosis by flow cytometry using the Annexin V assay. Results: Metamizole and paracetamol significantly inhibited cell proliferation in pancreatic cancer cells. After the addition of metamizole to PaTu 8988t cells, the rate of apoptosis was reduced after 3 h of incubation but significantly increased after 9 h of incubation. Conclusion: The oncogenic potential of pancreatic adenocarcinoma is mainly characterized by its extreme growth rate. Non-opioid analgesics such as metamizole and paracetamol are given as general anesthetics and postoperative analgesics. The combination of metamizole or paracetamol with cytotoxic therapeutic approaches may achieve synergistic effects. Further studies are necessary to identify the underlying mechanisms so that new therapeutic options may be developed for the treatment of this aggressive tumor.
title: Lettre n°282 de Paul d'Estournelles de Constant à Nicholas Murray Butler (19 juin 1917)
title: Letter number 282 from Paul d'Estournelles de Constant to Nicholas Murray Butler (June 19, 1917)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Bolalarni vaqtni chamalashga o'rgatish vazifalari. Bolalarni sutka qismlarini farqlashga, ularning tartibini aniqlashga o'rgatish.
Creators: name: Yo'ldasheva Shodiyona
Publisher: name: Zenodo
Year: 2025

description: Annotatsiya: Ushbu maqolada maktabgacha ta'lim tashkilotlarida bolalarning vaqtni idrok qilishi haqida fikrlar bildirilgan. Bolalarga ta'lim berishda o'yinli texnologiyalardan foydalanish va bu bevosita vaqtni aks ettiruvchi turli vositalarga aloqadorligi haqida qayd etilgan. Bolalarga vaqtni muhimligi, uni qanday o‘rganish va bilib olish mumkinligi quyidagi maqolada aks etgan. 

Kalit so'zlar: Vaqt, ko‘rgazmali metodlar, bilish jarayonlari, zamonaviy texnologiyalar, chamalash, vaqtni taqsimlash, hafta kunlari, vaqt idroki
Coriojassus loeiensis Dai, Dietrich & Zhang, 2015, sp. nov.
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Coriojassus
Coriojassus loeiensis

description: Coriojassus loeiensis sp. nov.
(Figs 1 G, H, 8A–E)
Male 7.4 mm long, 3.5 mm wide across humeral angles. Coloration and external morphology (Fig. 1 G, H) as in C. brunneus. Male pygofer with caudal margin slightly concave in lateral view, ventral process rounded apically with angulate ventroapical and preapical projections (Fig. 8 E). Subgenital plate evenly widened from base to apex, ventral margin slightly convex in lateral view, apex obliquely truncate (Fig. 8 D). Style apophysis twice as long as apodeme, sinuate, with prominent preapical spine, apex tapered (Fig. 8 A). Aedeagus with shaft curved dorsally through most of length (Fig. 8 B); without preapical teeth adjacent to gonopore, stem of paired apical processes as long as distance between distal projections (Fig. 8 C). Male genitalia as in C. brunneus except as follows: style in lateral view with apex abruptly bent posterad, with small dorsal preapical tooth in addition to larger medially projecting spine; aedeagus in lateral view without prominent subbasal ventral lobe, without pair of lateral teeth basad of gonopore.
Material examined. Holotype ♂, THAILAND: Loei, Na Haeo (bio. station). 5–12.v.2001, Constant & Grootaert [RISB].
Notes. This species resembles C. brunneus externally, but may be readily distinguished by the distinctive male genitalia. The species name is based on that of the Thai province in which the holotype was collected.
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on pages 11-13, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
Macrothrix squamosa Sars 1901
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Macrothricidae
Macrothrix
Macrothrix squamosa

description: Macrothrix squamosa Sars,1901.
(1) Timeantube Pond, Praia do Forte, Mata de São João, 12°34’41”S 38°00’47”W, 12.vii.2002, coll. L.M.A. Elmoor-Loureiro (EL00339). (2) Pond at Tororomba Hotel, Ilhéus, 14°59’29”S 38°59’59”W, 27.i.2006,coll. L.M.A. Elmoor-Loureiro (EL03240). (3) Waterbody on the road between Mucuri and BR-101, km 20, 17.iii.1995, coll. P.S. Young, C.B. Castro, A.E. Migotto, R.J.J. Silva, and C.A. Echeverria (MNRJ20274). (4) Waterbody near Nova Soure, on the road connecting BR-101 and BR-116, 28.ii.1995, coll. P.S. Young and C.S. Serejo (MNRJ20287). (5) Fish River, Itagibá, 14°11’– 14°12’S 39°39’– 39°42’W, x.2008 – vii.2009, coll. Sheila Bonfim de Jesus (SBJ, EL02777). (6) Reservoir in Santa Rita Stream, Itagibá, 14°11’14”S 39°42’27”W, x.2008 – vii.2009, coll. Sheila Bonfim de Jesus (SBJ).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 21, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment
Creators: name: Mayer, Ute
name: Benditz, Achim
name: Grässel, Susanne
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: MESENCHYMAL STEM-CELLS; MICRORNA EXPRESSION; ARTICULAR-CARTILAGE; CHONDROCYTES; BIOGENESIS; APOPTOSIS; GENOMICS; FAMILY;
subject: 610 Medizin

description: Osteoarthritis (OA) is characterized by a slowly progressing, irreversible loss of articular cartilage. Tissue engineering approaches for cartilage regeneration include stem cell-based strategies but not much is known about their repair capacity in an OA microenvironment. The aim of the present study was to identify factors regulating collagen expression during chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSC) in an OA microenvironment. Coculture with OA cartilage induced miR-29b expression in BMSC which inhibited collagen I and III expression. Elevated miR-29b expression resulted in higher caspase 3/7 activity and promoted apoptosis of BMSC in part by directly inhibiting the anti-apoptotic proteins Bcl-2 and Mcl-1. Stimulation with IFN-gamma induced miR-29b expression in BMSC. Our results suggest that miR-29b affects BMSC-based OA cartilage regeneration because expression of collagen III, mainly produced by undifferentiated BMSC, and collagen I, a marker for dedifferentiated chondrocytes, are inhibited by miR-29b thus influencing composition of the newly formed ECM. This might be critical to avoid formation of inferior fibrocartilage instead of hyaline cartilage. Furthermore, higher miR-29b expression promotes apoptosis either preventing excessive cell growth or reducing the number of BMSC undergoing chondrogenesis. Thus, miR-29b has both supportive but possibly also unfavourable effects on BMSC-based OA cartilage regeneration.
Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face − protocol of a multicenter, prospective, randomized, controlled, two-armed study
Creators: name: Kohl, E.
name: Koller, M.
name: Zeman, F.
name: Szeimies, R.-M.
name: Philipp-Dormston, W. G.
name: Prager, W.
name: Gerber, P. A.
name: Karrer, S.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: PDT, Study protocol, Cryosurgery, Methyl aminolevulinate, Daylight, AK, Skin aging, Prevention, Photorejuvenation
subject: 610 Medizin

description: Background
Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.

Methods/design
In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months. After preparation of the lesion and within 30 min after MAL application, patients expose themselves to daylight for 2 h. In the control group, lesion-directed cryosurgery is conducted at the first visit and, in the case of uncleared or new AK lesions, also at visits 2 to 5. The efficacy of the treatment is evaluated at visits 2 to 6 by documenting all existing and new AK lesions in the face. Cosmetic results and improvement of photoaging parameters are evaluated by means of a modified Dover scale.

Primary outcome parameter is the cumulative number of AK lesions observed between visits 2 and 6.

Secondary outcome parameters are complete clearance of AK, new AK lesions since the previous visit, cosmetic results independently evaluated by both patient and physician, patient-reported pain (visual analogue scale), patient and physician satisfaction scores with cosmetic results, and patient-reported quality of life (Dermatology Life Quality Index). Safety parameters are also documented (adverse events and serious adverse events).
Bypassing P-glycoprotein mediated efflux of afatinib by cyclodextrin complexation – Evaluation of intestinal absorption and anti-cancer activity
Creators: name: Parvathaneni, Vineela
name: Elbatanony, Rasha
name: Shukla, Snehal
name: Kulkarni, Nishant
name: Kanabar, Dipti
name: chauhan, Gautam
name: Ayehunie, Seyoum
name: Chen, Zhe-Sheng
name: Muth, Aaron
name: Gupta, Vivek
Publisher: name: Health Research Alliance
Year: 2025
Subjects: classificationCode: 321404
subject: Pharmaceutical delivery technologies
classificationCode: 321405
subject: Pharmaceutical sciences

description: A cyclodextrin complex of afatinib, a FDA-approved pan–ErbB inhibitor and known P-gp substrate, was developed
to enhance its bio-activity while also reducing p-glycoprotein (P-gp) efflux, thereby improving its transport across
the intestinal membrane. A sulfobutyl ether derivative of β-cyclodextrin (SBE-β-CD, pharmaceutical grade) was
selected based on preliminary phase solubility studies and molecular modeling to prepare an afatinib-cyclodextrin
inclusion complex. Various solid-state characterization studies were performed to confirm complex formation and
to evaluate its physicochemical properties. Results showed that complexation with SBE-β-CD enhanced afatinib's
stability in PBS (pH 7.4), as well as in simulated gastric (pH 2.0) and intestinal fluids (pH 6.5). In addition, the
cytotoxicity (reduced IC50 after complexation across multiple cancer cell lines with varied P-gp expression) and
tumor volume retraction ability (in-vitro 3D-spheroids of P-gp overexpressing cell lines) of afatinib were both enhanced
through cyclodextrin complexation. CD complexation effect of afatinib on P-gp efflux as well as transport
was assessed using in-vitro permeability studies (Caco-2 and EpiIntestinal® tissue models). Results demonstrated
that cyclodextrin complexation significantly increased the transport of afatinib across the gut membrane while
also reducing its efflux ratio, indicating its vital role in P-gp efflux modulation.
Trocnadella fasciana Li
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Trocnadella
Trocnadella fasciana

description: Trocnadella fasciana Li
Troncadella fasciana Li, 1995:211 –215 Distribution. China (Guizhou, Sichuan)
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on page 35, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
"zy.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for |y| cross section
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Study on P.Mich. VII 450 (inv. 2761) recto.
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 3
description: Transcription, drawings of letters and words, a time-table for a possible re-edition, annotations, bibliographical references and photo.
description: Source: 4MAR_21_3.2-15-2-4
description: created: n. d.
Streblocerus pygmaeus Sars 1901
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Macrothricidae
Streblocerus
Streblocerus pygmaeus

description: Streblocerus pygmaeus Sars, 1901.
(1) Pond on BA-697 road, near Nova Viçosa, 17°57’35”S 39°33’22”W, 22.i.1991, coll. L.M.A. Elmoor-Loureiro (EL02211). (2) Formoso River, pond 2, Trijunção Farm, Cocos, 14°47’18”S 45°56’42”W, 27.iv.2003, coll. L.M.A. Elmoor-Loureiro (EL00390).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 21, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
The Temporal Muscle of the Head Can Cause Artifacts in Optical Imaging Studies with Functional Near-Infrared Spectroscopy
Creators: name: Schecklmann, Martin
name: Mann, Alexander
name: Langguth, Berthold
name: Ehlis, Ann-Christine
name: Fallgatter, Andreas J.
name: Haeussinger, Florian B.
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: HUMAN BRAIN; BLOOD-FLOW; MOVEMENT ARTIFACTS; RELAXATION-TIMES; SKELETAL-MUSCLE; OXYGENATION; ACTIVATION; SIGNALS; FNIRS; NIRS; fNIRS; NIRS; optical topography; noise; artifact; temporal muscle; clenching teeth
subject: 610 Medizin

description: Background: Extracranial signals are themain source of noise in functional near- infrared spectroscopy (fNIRS) as light is penetrating the cortex but also skin and muscles of the head. Aim: Here we performed three experiments to investigate the contamination of fNIRS measurements by temporal muscle activity. Material and methods: For experiment 1, we provoked temporal muscle activity by instructing 31 healthy subjects to clench their teeth three times. We measured fNIRS signals over left temporal and frontal channels with an interoptode distance of 3 cm, in one short optode distance (SOD) channel (1 cm) and electromyography (EMG) over the edge of the temporal muscle. In experiment 2, we screened resting state fNIRS-fMRI (functional magnetic resonance imaging) data of one healthy subject for temporal muscle artifacts. In experiment 3, we screened a dataset of sound-evoked activity (n = 33) using bi-temporal probe-sets and systematically contrasted subjects presenting vs. not presenting artifacts and blocks/events contaminated or not contaminated with artifacts. Results: In experiment 1, we could demonstrate a hemodynamic-response-like increase in oxygenated (O(2)Hb) and decrease in deoxygenated (HHb) hemoglobin with a large amplitude and large spatial extent highly exceeding normal cortical activity. Correlations between EMG, SOD, and fNIRS artifact activity showed only limited evidence for associations on a group level with rather clear associations in a sub-group of subjects. The fNIRS-fMRI experiment showed that during the temporal muscle artifact, fNIRS is completely saturated by muscle oxygenation. Experiment 3 showed hints for contamination of sound-evoked oxygenation by the temporal muscle artifact. This was of low relevance in analyzing the whole sample. Discussion: Temporal muscle activity e. g., by clenching the teeth induces a large hemodynamic-like artifact in fNIRS measurements which should be avoided by specific subject instructions. Data should be screened for this artifact might be corrected by exclusion of contaminated blocks/events. The usefulness of established artifact correction methods should be evaluated in future studies. Conclusion: Temporal muscle activity, e. g., by clenching the teeth is one major source of noise in fNIRS measurements.
Valid gene expression normalization by RT-qPCR in studies on hPDL fibroblasts with focus on orthodontic tooth movement and periodontitis
Creators: name: Kirschneck, Christian
name: Batschkus, Sarah
name: Proff, Peter
name: Köstler, Josef
name: Spanier, Gerrit
name: Schröder, Agnes
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: REAL-TIME PCR; LIGAMENT CELLS; QUANTITATIVE PCR; MINIMUM INFORMATION; HOUSEKEEPING GENES; UP-REGULATION; IN-VITRO; HYPOXIA; RNA; IDENTIFICATION;
subject: 610 Medizin

description: Meaningful, reliable and valid mRNA expression analyses by real-time quantitative PCR (RT-qPCR) can only be achieved, if suitable reference genes are chosen for normalization and if appropriate RT-qPCR quality standards are met. Human periodontal ligament (hPDL) fibroblasts play a major mediating role in orthodontic tooth movement and periodontitis. Despite corresponding in-vitro gene expression studies being a focus of interest for many years, no information is available for hPDL fibroblasts on suitable reference genes, which are generally used in RT-qPCR experiments to normalize variability between samples. The aim of this study was to identify and validate suitable reference genes for normalization in untreated hPDL fibroblasts as well as experiments on orthodontic tooth movement or periodontitis (Aggregatibacter actinomycetemcomitans). We investigated the suitability of 13 candidate reference genes using four different algorithms (geNorm, NormFinder, comparative Delta C-q and BestKeeper) and ranked them according to their expression stability. Overall PPIB (peptidylprolyl isomerase A), TBP (TATA-box-binding protein) and RPL22 (ribosomal protein 22) were found to be most stably expressed with two genes in conjunction sufficient for reliable normalization. This study provides an accurate tool for quantitative gene expression analysis in hPDL fibroblasts according to the MIQE guidelines and shows that reference gene reliability is treatment-specific.
Trocnadella furculata Cai et He
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Trocnadella
Trocnadella furculata

description: Trocnadella furculata Cai et He
Trocnadella furculata Cai et He, 1998:20, fig. 1A–D Distribution. China (Henan)
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on page 35, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
"zpt_y16.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for normalised $p_T$ cross section for |y| < 1.6
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Alonella clathratula Sars 1896
Creators: name: Macêdo, Rafael Lacerda
name: Sousa, Francisco Diogo R.
name: Jesus, Sheila Bonfim de
name: Nunesmaia, Bárbara Janaina Bezerra
name: Branco, Christina Wyss Castelo
name: Elmoor-Loureiro, Lourdes M. A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Branchiopoda
Diplostraca
Chydoridae
Alonella
Alonella clathratula

description: Alonella clathratula Sars, 1896.
(1) Formoso River, pond 1, head office of Trijunção Farm, Cocos, 14°49’02”S 45°58’35”W, 26.iv.2003, coll. L.M.A. Elmoor-Loureiro (EL03274) and 19.x.2017, leg. Bárbara M. Fonseca (EL03296). (2) Pond at Santa Luzia Farm, Cocos, 14°54’47”S 45°58’19”W, 27.iv.2003, coll. L.M.A. Elmoor-Loureiro (EL03285). (3) Pond at BR-020, Roda Velha, São Desidério, 12°47’18”S 45°57’06”W, coll. L.M.A. Elmoor-Loureiro (EL00480). (4) Capivara Pond, Arembepe, Camaçari, 12°45’42”S 38°10’08”W, 12.vii.2002, coll. L.M.A. Elmoor-Loureiro (EL03260). (5) Timeantube Pond, Praia do Forte, Mata de São João, 12°34’41”S 38°00’47”W, 12.vii.2002, coll. L.M.A. Elmoor-Loureiro (EL03269).
description: Published as part of Macêdo, Rafael Lacerda, Sousa, Francisco Diogo R., Jesus, Sheila Bonfim de, Nunesmaia, Bárbara Janaina Bezerra, Branco, Christina Wyss Castelo & Elmoor-Loureiro, Lourdes M. A., 2021, Cladocera (Crustacea, Branchiopoda) species of Bahia State, Brazil: a critical update on species descriptions, distributions, and new records, pp. 1-26 in Nauplius (e 2021011) (e 2021011) 29 on page 21, DOI: 10.1590/2358-2936e2021011, http://zenodo.org/record/10904828
Trocnadella fuscipennis Li
Creators: name: Dai, Wu
name: Dietrich, Christopher H.
name: Zhang, Yalin
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Trocnadella
Trocnadella fuscipennis

description: Trocnadella fuscipennis Li
Trocnadella fuscipennis Li, 1995:211 –215 Distribution. China (Guizhou, Zhejiang)
description: Published as part of Dai, Wu, Dietrich, Christopher H. & Zhang, Yalin, 2015, A review of the leafhopper tribe Hyalojassini (Hemiptera: Cicadellidae: Iassinae) with description of new taxa, pp. 1-142 in Zootaxa 3911 (1) on page 35, DOI: 10.11646/zootaxa.3911.1.1, http://zenodo.org/record/253710
The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation
Creators: name: Weber, Daniela
name: Frauenschläger, Katrin
name: Ghimire, Sakhila
name: Peter, Katrin
name: Panzer, Isabella
name: Hiergeist, Andreas
name: Weber, Markus
name: Kutny, Daniel
name: Wolff, Daniel
name: Grube, Matthias
name: Huber, Elisabeth
name: Oefner, Peter
name: Gessner, Andre
name: Hehlgans, Thomas
name: Herr, Wolfgang
name: Holler, Ernst
Publisher: name: Universität Regensburg
Year: 2017
Subjects: subject: ALPHA-DEFENSINS; GVHD; MORTALITY; INTERLEUKIN-22;
subject: 610 Medizin

description: Intestinal microbiota disruption is associated with acute gastrointestinal (GI) Graft-versus-Host Disease (GvHD) and poor outcome after allogeneic stem cell transplantation (ASCT). Here, in a retrospective analysis of 200 patients undergoing ASCT at the Regensburg University Medical Center, we assessed the relative expression of Paneth cell antimicrobial peptides (AMPs), Human Defensins (HD) 5 and 6 and regenerating islet-derived 3 alpha (Reg3 alpha), in 292 human intestinal biopsies as well as Reg3a serum levels in relation to acute GI GvHD. In the absence of GI GvHD, the relative expression of Paneth cell AMPs was significantly higher in the small intestine (duodenum to ileum) than in the stomach and large intestine (cecum to rectum) for Reg3a (p <= 0.001), HD5 (p <= 0.002) and HD6 (p <= 0.02). Acute stage 2-4 GI GvHD was associated with reduced expression of AMPs in the small intestine (p <= 0.01) in comparison to stage 0-1 disease, accompanied by a decrease in Paneth cell count in case of severe acute GI GvHD (p<0.001). The opposite held true for the large intestine as we found stage 2-4 GI GvHD correlated with significantly higher expression of HD5, HD6, and Reg3a compared to mild or no acute GI GvHD (p <= 0.002). Severe GI GvHD in both the lower and the upper GI tract also correlated with higher serum concentrations of Reg3a (p = 0.002). As indirect markers of intestinal microbiome diversity low levels of urinary 3-indoxyl sulfate levels were associated with severe stages of acute GI GvHD compared to mild stage or no acute GI GvHD (p = 0.05). In conclusion, acute GI GvHD correlates with intestinal expression of HD5, HD6 and Reg3a as well as Reg3a serum levels and is associated with intestinal dysbiosis.
title: Lettre n°1457 de Paul d'Estournelles de Constant à Nicholas Murray Butler (17 décembre 1923)
title: Letter number 1457 from Paul d'Estournelles de Constant to Nicholas Murray Butler (December 17, 1923)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France