title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±Ð° Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÐ°Ð¼Ð¸ ÑÐµÑÐµÐ±ÑÐ° Ð½Ð° Ð¸Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ Ð²Ð¼ÐµÑÐ¸Ð²Ð°ÑÑÑÑ Ð² Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ Ð¼ÐµÐ´Ð¸ Ð¼ÑÑÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The influence of the administration fashion with silver nanoparticles on their ability to interfere into the mice metabolism
Creators: name: ÐÐ°Ð³Ð°Ð·ÐµÐ½ÐºÐ¾Ð²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ ÑÐµÑÐµÐ±ÑÐ°
Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ Ð¼ÐµÐ´Ð¸
ÑÑÐ°ÑÑÑ Ð¼ÐµÐ´Ð¸
Ð¸Ð¾Ð½Ñ ÑÐµÑÐµÐ±ÑÐ°
Ð¼ÐµÐ´Ñ
ÑÐµÑÑÐ»Ð¾Ð¿Ð»Ð°Ð·Ð¼Ð¸Ð½
silver nanoparticles
copper metabolism
copper status
silver ions
copper
ceruloplasmin

description: ÐÐ·Ð²ÐµÑÑÐ½Ð¾, ÑÑÐ¾ Ð¸Ð¾Ð½Ñ Ag(I) Ð¸Ð·Ð¾ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð½Ñ Ð¸Ð¾Ð½Ð°Ð¼ Cu(I), Ð¿Ð¾ÑÑÐ¾Ð¼Ñ Ð¿ÑÐ¸ Ð¿Ð¾Ð¿Ð°Ð´Ð°Ð½Ð¸Ð¸ Ð² Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼ Ag(I) Ð¼Ð¾Ð¶ÐµÑ Ð²ÐºÐ»ÑÑÐ°ÑÑÑÑ Ð² Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ¸ÐºÐ» Ð¼ÐµÐ´Ð¸ Ð¸ Ð²Ð»Ð¸ÑÑÑ Ð½Ð° Ð½ÐµÐ³Ð¾. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ° Ð½Ð° Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ Ð¼ÐµÐ´Ð¸ Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð° Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð¸Ð¼Ð¸ Ð¼ÑÑÐµÐ¹. ÐÐ»Ñ ÑÑÐ¾Ð³Ð¾ Ð±ÑÐ»Ð¸ ÑÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð´Ð²Ðµ Ð³ÑÑÐ¿Ð¿Ñ Ð¼ÑÑÐµÐ¹, ÐºÐ¾ÑÐ¾ÑÑÐ¼ Ð² ÑÐµÑÐµÐ½Ð¸Ðµ 5 Ð´Ð½ÐµÐ¹ Ð²Ð²Ð¾Ð´Ð¸Ð»Ð¸ Ð¿Ð¾ 100 Ð¼ÐºÐ» Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ° ÑÐ°Ð·Ð¼ÐµÑÐ¾Ð¼ 75 Ð½Ð¼ Ð²Ð½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð¾ Ð¸Ð»Ð¸ Ð¿ÐµÑÐ¾ÑÐ°Ð»ÑÐ½Ð¾. ÐÐ¾ÑÐ»Ðµ Ð²ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¸Ð· ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ° Ñ Ð½Ð¸Ñ ÑÐ¾Ð±Ð¸ÑÐ°Ð»Ð¸ ÐºÑÐ¾Ð²Ñ, Ð¾Ð±ÑÐ°Ð·ÐµÑ Ð¿ÐµÑÐµÐ½Ð¸ Ð¸ ÑÐµÐºÐ°Ð»Ð¸Ð¸ Ð¸Ð· ÑÐ¾Ð½ÐºÐ¾Ð³Ð¾ ÐºÐ¸ÑÐµÑÐ½Ð¸ÐºÐ° Ð´Ð»Ñ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð¾ÐºÑÐ¸Ð´Ð°Ð·Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸, ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ ÑÐµÑÐµÐ±ÑÐ° Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¼Ð¸ÐºÑÐ¾Ð±Ð¸Ð¾ÑÑ. Ð£ Ð¼ÑÑÐµÐ¹, Ð¿Ð¾Ð»ÑÑÐ°Ð²ÑÐ¸Ñ Ð²Ð½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½ÑÐµ Ð¸Ð½ÑÐµÐºÑÐ¸Ð¸, Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐµÑÑÐ»Ð¾Ð¿Ð»Ð°Ð·Ð¼Ð¸Ð½Ð° Ð¿Ð°Ð´Ð°Ð»Ð° Ð¿Ð¾ÑÑÐ¸ Ð´Ð¾ Ð½ÑÐ»Ñ, Ð² ÑÐ¾ Ð²ÑÐµÐ¼Ñ ÐºÐ°Ðº Ð¿ÑÐ¸ Ð¿ÐµÑÐ¾ÑÐ°Ð»ÑÐ½Ð¾Ð¼ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ð¸ Ð¾ÐºÑÐ¸Ð´Ð°Ð·Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐ½Ð¸Ð¶Ð°Ð»Ð°ÑÑ Ð¿ÑÐ¸Ð¼ÐµÑÐ½Ð¾ Ð² 2 ÑÐ°Ð·Ð°. ÐÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ñ ÑÐµÑÐµÐ±ÑÐ° Ð² ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐµ Ð¸ Ð¿ÐµÑÐµÐ½Ð¸ Ð±ÑÐ»Ð° Ð±Ð¾Ð»ÐµÐµ, ÑÐµÐ¼ Ð² 10 ÑÐ°Ð· Ð½Ð¸Ð¶Ðµ Ñ Ð¼ÑÑÐµÐ¹, Ð¿Ð¾Ð»ÑÑÐ°Ð²ÑÐ¸Ñ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ Ð¾ÑÐ°Ð»ÑÐ½Ð¾, Ð¾Ð´Ð½Ð°ÐºÐ¾, Ð¿ÑÐµÐ²ÑÑÐ°Ð»Ð° ÑÐ¾Ð½Ð¾Ð²ÑÐµ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ. Ð£ Ð¼ÑÑÐµÐ¹, Ð¿Ð¾Ð»ÑÑÐ°Ð²ÑÐ¸Ñ Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ Ð¿ÐµÑÐ¾ÑÐ°Ð»ÑÐ½Ð¾, ÑÐ¸ÑÑ Ð¸Ð»Ð¸ ÑÐ°Ð·Ð½Ð¾Ð¾Ð±ÑÐ°Ð·Ð¸Ðµ Ð¼Ð¸ÐºÑÐ¾Ð±Ð¸Ð¾ÑÑ ÑÐ¾Ð½ÐºÐ¾Ð³Ð¾ ÐºÐ¸ÑÐµÑÐ½Ð¸ÐºÐ° Ð½Ðµ Ð¾ÑÐ»Ð¸ÑÐ°Ð»Ð¸ÑÑ Ð¾Ñ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½ÑÑ Ð¼ÑÑÐµÐ¹. Ð¢Ð°ÐºÐ¸Ð¼ Ð¾Ð±ÑÐ°Ð·Ð¾Ð¼, Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ ÑÐµÑÐµÐ±ÑÐ°, Ð²Ð²ÐµÐ´ÐµÐ½Ð½ÑÐµ Ð¿ÐµÑÐ¾ÑÐ°Ð»ÑÐ½Ð¾ Ð´ÐµÐ¹ÑÑÐ²ÑÑÑ Ð¼ÐµÐ´Ð»ÐµÐ½Ð½ÐµÐµ Ð½Ð° Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ Ð¼ÐµÐ´Ð¸, ÑÐµÐ¼ Ð¸Ð½ÑÐµÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð²Ð½ÑÑÑÐ¸Ð±ÑÑÑÐ¸Ð½Ð½Ð¾.
description: Since Ag(I) ions is isoelectronic to Cu(I) ions, it can be included in the copper metabolism and affects it. In this work, the effect the silver nanoparticles on the copper metabolism depended on the method their administration was studied. Two groups of mice were formed, which were injected with 100 Î¼l of 75 nm silver nanoparticles intraperitoneally, or orally, for 5 days. In mice injected with silver nanoparticles intraperitoneally, oxidase activity fold almost to null. At the same time the mice administered with silver nanoparticles orally, the oxidase activity decreased by about 2 times only. In blood serum and liver, silver concentration was more than 10 times lower in the mice intraperitoneally treated with nanoparticles; however, in both cases, silver concentration exceeded the background values. Mice treated with nanoparticles orally, had the same variety of microbiota of the small intestine as control mice. Thus, the oral administration of silver nanoparticles act slower on copper metabolism than their administration via intraperitoneal injection.