cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
From paper to practice: An evaluation of the impact of the 1989 NACI guidelines for universal hepatitis B screening in pregnancy.
Creators: name: Seviour, Rosann.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Health Sciences, Obstetrics and Gynecology.

description: The development and release of clinical practice guidelines continue unabated. Yet the question remains: do practice guidelines guide practitioners? This study examines the implementation of guidelines published by Canada's National Advisory Committee on Immunization (NACI) on hepatitis B screening in pregnancy. Hepatitis B is transmitted to infants from their chronic carrier mothers during the perinatal period. Asymptomatic HBsAg positive mothers are at risk of transmitting their infection to their newborns at a rate of 20 to 30%. Mothers who are also HBeAg positive transmit the infection at a rate of 70-90%. Ninety percent of infants infected in the perinatal period will become chronic carriers. Such infants have an increased risk for chronic active hepatitis, cirrhosis and hepatocellular carcinoma. Twenty-five percent will die of chronic liver disease in early adulthood. The use of hepatitis B immune globulin and vaccine after birth can prevent up to 90% of hepatitis B infections in infants. Successful immunoprophylaxis of an infant requires that her carrier mother be identified prior to giving birth. In 1989, after years of recommending screening on a selective high risk basis, NACI recommended screening all pregnant women for hepatitis B surface antigen (HBsAg). If testing was not done during pregnancy it was to be done at the time of delivery.
Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome
Creators: name: Habib, Raneem
name: Neitzel, Heidemarie
name: Ernst, Aurelie
name: Wong, John K. L.
name: Goryluk-Kozakiewicz, Bozenna
name: Gerlach, Antje
name: Demuth, Ilja
name: Sperling, Karl
name: Chrzanowska, Krystyna
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: Nijmegen breakage syndrome
subject: Cell line
subject: Unbalanced translocation
subject: Proliferative advantage
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background: Nijmegen breakage syndrome is an autosomal recessive disorder characterized by microcephaly, immunodeficiency, hypersensitivity to X-irradiation, and a high predisposition to cancer. Nibrin, the product of the NBN gene, is part of the MRE11/RAD50 (MRN) complex that is involved in the repair of DNA double strand breaks (DSBs), and plays a critical role in the processing of DSBs in immune gene rearrangements, telomere maintenance, and meiotic recombination. NBS skin fibroblasts grow slowly in culture and enter early into senescence. Case presentation: Here we present an incidental finding. Skin fibroblasts, derived from a 9 year old NBS patient, showed a mosaic of normal diploid cells (46,XY) and those with a complex, unbalanced translocation. The aberrant karyotype was analysed by G-banding, comparative genomic hybridization, and whole chromosome painting. The exact breakpoints of the derivative chromosome were mapped by whole genome sequencing: 45,XY,der(6)(6pter → 6q11.1::13q11 → 13q21.33::20q11.22 → 20qter),-13. The deleted region of chromosomes 6 harbors almost 1.400 and that of chromosome 13 more than 500 genes, the duplicated region of chromosome 20 contains about 700 genes. Such unbalanced translocations are regularly incompatible with cellular survival, except in malignant cells. The aberrant cells, however, showed a high proliferation potential and could even be clonally expanded. Telomere length was significantly reduced, hTERT was not expressed. The cells underwent about 50 population doublings until they entered into senescence. The chromosomal preparation performed shortly before senescence showed telomere fusions, premature centromere divisions, endoreduplications and tetraploid cells, isochromatid breaks and a variety of marker chromosomes. Inspection of the site of skin biopsy 18 years later, presented no evidence for abnormal growth. Conclusions: The aberrant cells had a significant selective advantage in vitro. It is therefore tempting to speculate that this highly unbalanced translocation could be a primary driver of cancer cell growth.
Mixture risk assessment and human biomonitoring: lessons learnt from HBM4EU
Creators: name: Kolossa-Gehring, Marike
name: Luijten, Mirjam
name: Vlaanderen, Jelle
name: Kortenkamp, Andreas
Publisher: name: My University
Year: 2023

description: Unintentional chemical mixtures that are present in the environment are of societal concern as the (environmental) chemicals contained therein, either singly or in combination, may possess properties that are hazardous (toxic) for human health. The current regulatory practice, however, is still largely based on evaluating single chemical substances one-by-one. Over the years various research efforts have delivered tools and approaches for risk assessment of chemical mixtures, but many of these were not considered sufficiently mature for regulatory implementation. This is (partly) due to mixture risk assessment (MRA) being very complex because of the large number of chemicals present in the environment. A key element in risk assessment is information on actual exposures in the population of interest. To date, information on actual personal (internal) mixture exposures is largely absent, severely limiting MRA. The use of human biomonitoring data may improve this situation. Therefore, we investigated within the European Human Biomonitoring Initiative (HBM4EU) various approaches to assess combined exposures and MRA. Based on the insights and lessons learnt in the context of the HBM4EU project, conclusions as well as recommendations for policy development regarding chemical mixtures and for further research were drafted. These conclusions and recommendations relate to both exposure and adverse health effects in humans. The recommendations were discussed with stakeholders in a workshop held in October 2021. There was considerable support and agreement with the spirit, scope and intention of the draft recommendations. Here we describe the lessons learnt on mixture risk assessment through the HBM4EU project and present the final recommendations. Overall, HBM4EU results demonstrated the potential of human biomonitoring as an instrument to obtain insight into the real-life mixtures the human population is exposed to. Also, HBM4EU results demonstrated that chemical mixtures are of public health concern. In the majority of the cases, it was possible to identify risk drivers, i.e. chemicals that contribute more strongly than others to the health risk. The novel approaches to identify co-occurrence patterns demonstrated clusters of co-occurring chemicals; chemicals in these mixture clusters are regulated independently under different legislative frameworks. Moreover, HBM4EU data and expertise can support a science-based derivation of a Mixture Assessment Factor and gauge potential impacts on the population's exposure to chemicals. While further expansion is needed on various aspects of the mixture activities carried out in the context of HBM4EU, application of available methodologies for mixture risk assessment should already be implemented to the degree possible. © 2023 The Authors
3283332.pdf
Creators: name: Sinobad, Milan
name: Monat, Christelle
name: Luther-Davies, Barry
name: Ma, Pan
name: Madden, Stephen
name: Moss, David
name: Mitchell, Arnan
name: Allioux, David
name: orobtchouk, regis
name: Boutami, Salim
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplementary material red-lined version
THEORETICAL AND PRACTICAL PROBLEMS OF THE LEGAL STATUS OF  COMMERCIALLY CONFIDENTIAL INFORMATION
Creators: name: Raimova, Nargiza
Publisher: name: Zenodo
Year: 2024

description: Information, exactly confidential information, is the most important component of the development of society in formative modern world.  The current civil society is gradually turning from an informed to the information, so we can fearlessly say that the 21th century is considered to be the age of information. Information is a very important and necessary element of any activity of man, society and the state in the public, social-economic and political spheres.
Accuracy-speed relationships of a robotic filament winding cell.
Creators: name: Chan, Seng-Kum.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Engineering, Mechanical.

description: This thesis describes the background research and the development of a robot based filament winding cell. The cell was implemented using an industrial robot (ASEA IRB 6/2) and an in-house mandrel drive mechanism, both being coordinated by a personal computer. Filament winding is a process in which continuous fibres are placed on a rotating mandrel to cover the entire surface, under controlled tension forming a composite component. Traditionally, filament winding is carried out on multi-axis numerically controlled lathe-like machines. There are two major parts in this research. The first part deals with the cell control structure theory and the second deals with the experimental validation of the control structure. Communication protocols, user interface software, control hardware specifications and procedures are elaborated in detail. To simplify the experimental work, a highly automated robotic control software program was written. This program reduces the complexities of operating the robot and ensures accurate repeatable results. The applications program was based upon an expert system approach. The factors studied were the speed versus the accuracy, the accuracy of the payout eye position, the effects of the segment's length and winding speed used for the approximation of the fibre path. Validation of the control theory is tested experimentally using a simple cylindrical mandrel in various configurations and an asymmetrical S-mandrel.
3286725.pdf
Creators: name: Chemnitz, Mario
name: Scheibinger, Ramona
name: Gaida, Christian
name: Gebhardt, Martin
name: Stutzki, Fabian
name: Pumpe, Sebastian
name: Kobelke, Jens
name: Tünnermann, Andreas
name: Limpert, Jens
name: Schmidt, Markus
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Information
PROMETHEUS - Prioritization Of chemicals: a METHodology Embracing PBT parameters into a Unified Strategy
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: subject: prioritization
subject: PBT
subject: in silico methods
subject: integrated system
subject: Chemikalien
subject: Chemicals

description: Ziel des PROMETHEUS-Projektes ist es, ein Konzept für ein Programm zur Priorisierung von Substanzen innerhalb des PBT-Assessments zu entwickeln. Grundlage hierfür sind die Nutzung und die Implementierung einer Vielzahl von in-silico Modellen für P, B und T (in Zusammenarbeit mit dem CALEIDOS LIFE Projekt), um in naher Zukunft ein Pilotprogramm für das PBT-Assessment lauffähig zur Verfügung stellen zu können. Das entwickelte Softwarekonzept beruht auf der Zusammenfassung vielfältiger Modelle, die aus entsprechenden experimentellen Daten ausgewählter Endpunkte algorithmisch erhalten wurden. Das so integrierte System wurde schrittweise einer Validierung unterzogen, indem seine Vorhersagefähigkeit für eine Reihe von Chemikalien überprüft wurde, die entweder von Behörden als PBT eingestuft wurden, oder solche die bezüglich PBT in der Literatur als unbedenklich gelten oder zu denen nur zu wenigen Eigenschaften Informationen vorliegen. Die Ergebnisse der Validierung des integrierten Systems zeigen eine erfolgreiche Identifizierung und Priorisierung von PBT- und vPvBVerbindungen gegenüber entsprechend unbedenklich geltenden Verbindungen.Quelle: http://www.umweltbundesamt.de
description: Ziel des PROMETHEUS-Projektes ist es, ein Konzept für ein Programm zur Priorisierung von Substanzen innerhalb des ⁠PBT⁠-Assessments zu entwickeln. Grundlage hierfür sind die Nutzung und die Implementierung einer Vielzahl von in-silico Modellen für P, B und T (in Zusammenarbeit mit dem CALEIDOS LIFE Projekt), um in naher Zukunft ein Pilotprogramm für das PBT-Assessment lauffähig zur Verfügung stellen zu können. Das entwickelte Softwarekonzept beruht auf der Zusammenfassung vielfältiger Modelle, die aus entsprechenden experimentellen Daten ausgewählter Endpunkte algorithmisch erhalten wurden. Das so integrierte System wurde schrittweise einer Validierung unterzogen, indem seine Vorhersagefähigkeit für eine Reihe von Chemikalien überprüft wurde, die entweder von Behörden als PBT eingestuft wurden, oder solche die bezüglich PBT in der Literatur als unbedenklich gelten oder zu denen nur zu wenigen Eigenschaften Informationen vorliegen. Die Ergebnisse der Validierung des integrierten Systems zeigen eine erfolgreiche Identifizierung und Priorisierung von PBT- und vPvBVerbindungen gegenüber entsprechend unbedenklich geltenden Verbindungen.
Barriers and facilitators to implementing addiction medicine fellowships: a qualitative study with fellows, medical students, residents and preceptors
Creators: name: Klimas, Jan
name: Small, W.
name: Ahamad, K.
name: Cullen, W.
name: Mead, A.
name: Rieb, L.
name: Wood, E.
name: McNeil, Ryan, 1982-
Publisher: name: BioMed Central
Year: 2017

description: Background: Although progress in science has driven advances in addiction medicine, this subject has not been adequately taught to medical trainees and physicians. As a result, there has been poor integration of evidence-based practices in addiction medicine into physician training which has impeded addiction treatment and care. Recently, a number of training initiatives have emerged internationally, including the addiction medicine fellowships in Vancouver, Canada. This study was undertaken to examine barriers and facilitators of implementing addiction medicine fellowships. Methods: We interviewed trainees and faculty from clinical and research training programmes in addiction medicine at St Paul’s Hospital in Vancouver, Canada (N = 26) about barriers and facilitators to implementation of physician training in addiction medicine. We included medical students, residents, fellows and supervising physicians from a variety of specialities. We analysed interview transcripts thematically by using NVivo software. Results: We identified six domains relating to training implementation: (1) organisational, (2) structural, (3) teacher, (4) learner, (5) patient and (6) community related variables either hindered or fostered addiction medicine education, depending on context. Human resources, variety of rotations, peer support and mentoring fostered implementation of addiction training. Money, time and space limitations hindered implementation. Participant accounts underscored how faculty and staff facilitated the implementation of both the clinical and the research training. Conclusions: Implementation of addiction medicine fellowships appears feasible, although a number of barriers exist. Research into factors within the local/practice environment that shape delivery of education to ensure consistent and quality education scale-up is a priority.
title: Two-photon autofluorescence lifetime imaging of human skin papillary dermis in vivo
title: assessment of blood capillaries and structural proteins localization
titleType: Subtitle
Creators: name: Shirshin, Evgeny A.
name: Gurfinkel, Yury I.
name: Priezzhev, Alexander V.
name: Fadeev, Victor V.
name: Lademann, Juergen
name: Darvin, Maxim E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Biological fluorescence
subject: Fluorescence imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The papillary dermis of human skin is responsible for its biomechanical properties and for supply of epidermis with chemicals. Dermis is mainly composed of structural protein molecules, including collagen and elastin, and contains blood capillaries. Connective tissue diseases, as well as cardiovascular complications have manifestations on the molecular level in the papillary dermis (e.g. alteration of collagen I and III content) and in the capillary structure. In this paper we assessed the molecular structure of internal and external regions of skin capillaries using two-photon fluorescence lifetime imaging (FLIM) of endogenous compounds. It was shown that the capillaries are characterized by a fast fluorescence decay, which is originated from red blood cells and blood plasma. Using the second harmonic generation signal, FLIM segmentation was performed, which provided for spatial localization and fluorescence decay parameters distribution of collagen I and elastin in the dermal papillae. It was demonstrated that the lifetime distribution was different for the inner area of dermal papillae around the capillary loop that was suggested to be due to collagen III. Hence, we propose a generalized approach to two-photon imaging of the papillary dermis components, which extends the capabilities of this technique in skin diagnosis.
Document engineering of complex software specifications
Creators: name: Nojoumian, Mehrdad
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Computer Science.

description: The research presented in this thesis aims at document engineering of complex specifications, of which the UML Superstructure Specification (version 2.1) is our initial target. Document engineering deals with principles, tools and processes that improve our ability to create, manage, and maintain documents [40]. Our motivation is that such specifications are dense and intricate to use, and tend to have complicated structures with lots of repetitive, or 'boilerplate' material. End users cannot use them efficiently because of the general complexity of the document. Our objective and main contribution in this thesis is therefore to create an approach that allowed us to re-engineer PDF-based documents, and to illustrate how to make more usable versions of electronic documents such as specifications, conference proceedings, technical books, etc so that end-users to have a better experience with them. The first step was to extract the logical structure of the document. Our initial assumption was that, many key concepts of a document are expressed in this structure, which includes the headings of the chapters, sections, subsections, etc. We demonstrated this by analyzing some data, and created a special-purpose parser to generate a well-formed XML document with various types of tags. In the next phase, we created a user interface for end users by generating a multi-layer HTML version of the document to facilitate document browsing, navigating, and concept exploration. Although our targeted document was the UML Superstructure Specification, we chose a general approach for most phases of our work including format conversions, logical structure extraction, text extraction, hypertext generation, etc. Therefore, by minor adjustments we can process other complex documents to gain our mentioned goals. We also established the major infrastructure for a new document engineering framework.
title: Capturing domain knowledge from multiple sources
title: the rare bone disorders use case
titleType: Subtitle
Creators: name: Groza, Tudor
name: Tudorache, Tania
name: Robinson, Peter N.
name: Zankl, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Lately, ontologies have become a fundamental building block in the process of formalising and storing complex biomedical information. The community-driven ontology curation process, however, ignores the possibility of multiple communities building, in parallel, conceptualisations of the same domain, and thus providing slightly different perspectives on the same knowledge. The individual nature of this effort leads to the need of a mechanism to enable us to create an overarching and comprehensive overview of the different perspectives on the domain knowledge. Results We introduce an approach that enables the loose integration of knowledge emerging from diverse sources under a single coherent interoperable resource. To accurately track the original knowledge statements, we record the provenance at very granular levels. We exemplify the approach in the rare bone disorders domain by proposing the Rare Bone Disorders Ontology (RBDO). Using RBDO, researchers are able to answer queries, such as: “What phenotypes describe a particular disorder and are common to all sources?” or to understand similarities between disorders based on divergent groupings (classifications) provided by the underlying sources.
title: The Impact of Different Levels of Adaptive Iterative Dose Reduction 3D on Image Quality of 320-Row Coronary CT Angiography
title: A Clinical Trial
titleType: Subtitle
Creators: name: Feger, S.
name: Rief, M.
name: Zimmermann, E.
name: Martus, P.
name: Schuijf, J. D.
name: Blobel, J.
name: Richter, F.
name: Dewey, M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Purpose The aim of this study was the systematic image quality evaluation of coronary CT angiography (CTA), reconstructed with the 3 different levels of adaptive iterative dose reduction (AIDR 3D) and compared to filtered back projection (FBP) with quantum denoising software (QDS). Methods Standard-dose CTA raw data of 30 patients with mean radiation dose of 3.2 ± 2.6 mSv were reconstructed using AIDR 3D mild, standard, strong and compared to FBP/QDS. Objective image quality comparison (signal, noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contour sharpness) was performed using 21 measurement points per patient, including measurements in each coronary artery from proximal to distal. Results Objective image quality parameters improved with increasing levels of AIDR 3D. Noise was lowest in AIDR 3D strong (p≤0.001 at 20/21 measurement points; compared with FBP/QDS). Signal and contour sharpness analysis showed no significant difference between the reconstruction algorithms for most measurement points. Best coronary SNR and CNR were achieved with AIDR 3D strong. No loss of SNR or CNR in distal segments was seen with AIDR 3D as compared to FBP. Conclusions On standard- dose coronary CTA images, AIDR 3D strong showed higher objective image quality than FBP/QDS without reducing contour sharpness.
3286725.pdf
Creators: name: Chemnitz, Mario
name: Scheibinger, Ramona
name: Gaida, Christian
name: Gebhardt, Martin
name: Stutzki, Fabian
name: Pumpe, Sebastian
name: Kobelke, Jens
name: Tünnermann, Andreas
name: Limpert, Jens
name: Schmidt, Markus
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental Information
Laboratory reactor design and the precision of parameter estimates.
Creators: name: Courdin, Marie Claire.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Chemical.

description: This study is concerned with investigating the dependence of the precision of estimated kinetic parameters on the type of reactor used for performing the kinetic measurements. Two ideal reactors, the plug-flow reactor (PFR) and the continuous-stirred-tank reactor (CSTR), were simulated using a Monte-Carlo computer simulation. Parameters were estimated using nonlinear multiresponse estimation techniques, and the distributional characteristics of the parameter estimates were calculated. Comparison between the reactors involved the study of overall measures of precision such as the size, shape and orientation of the 95% joint confidence region, and the determinant of the covariance matrix of the parameter estimates. Five variables were identified as having a possible affect on the precision: the nature of the reaction network, the kinetic model, the magnitudes of the rate parameters, the covariance structure of the responses, and the experimental design. The dependence of parameter precision on these variables is presented along with recommendations for determining the reactor type to give the most precise kinetic parameters.
The hybrid solution for the fundamental plane
Creators: name: D'Onofrio, M.
name: Fasano, G.
name: Moretti, A.
name: Marziani, P.
name: Bindoni, D.
name: Fritz, J.
name: Varela, J.
name: Bettoni, D.
name: Cava, A.
name: Poggianti, B.
name: Gullieuszik, M.
name: Kjærgaard, P.
name: Moles, M.
name: Vulcani, B.
name: Omizzolo, A.
name: Couch, Warrick
name: Dressler, A.
Publisher: name: Swinburne
Year: 2024

description: By exploiting the data base of early-type galaxy (ETG) members of the WINGS survey of nearby clusters, we address here the long debated question of the origin and shape of the Fundamental Plane (FP). Our data suggest that different physical mechanisms concur in shaping and 'tilting' the FP with respect to the virial plane (VP) expectation. In particular, a 'hybrid solution' in which the structure of galaxies and their stellar population are the main contributors to the FP tilt seems to be favoured. We find that the bulk of the tilt should be attributed to structural non-homology, while stellar population effects play an important but less crucial role. In addition, our data indicate that the differential FP tilt between the V and K band is due to a sort of entanglement between structural and stellar population effects, for which the inward steepening of colour profiles (V - K) tends to increase at increasing the stellar mass of ETGs. The same kind of analysis applied to the ATLAS3D and Sloan Digital Sky Survey (SDSS) data in common with WINGS (WSDSS throughout the paper) confirms our results, the only remarkable difference being the less important role that our data attribute to the stellar mass-to-light-ratio (stellar populations) in determining the FP tilt. The ATLAS3D data also suggest that the FP tilt depends as well on the dark matter (DM) fraction and on the rotational contribution to the kinetic energy (Vrot/σ), thus again pointing towards the above-mentioned 'hybrid solution'. We show that the global properties of the FP, i.e. its tilt and tightness, can be understood in terms of the underlying correlation among mass, structure and stellar population of ETGs, for which, at increasing the stellar mass, ETGs become (on average) 'older' and more centrally concentrated. Finally, we show that a Malmquist-like selection effect may mimic a differential evolution of the mass-to-light ratio for galaxies of different masses. This should be taken into account in the studies investigating the amount of the so-called 'downsizing' phenomenon.
title: Récit d'une épidémie d'auparnaq
title: An outbreak of auparnaq
titleType: AlternativeTitle
Creators: name: Mahieu, Marc-Antoine
name: Pilurtuut, Tukirqi
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Inuktitut (dialecte du Nunavik)
subject: ike

description: Conforms to: oai:crdo.vjf.cnrs.fr:cocoon-49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
description: Lizzie Niviaxie se souvient d'une épidémie d'auparnaq (maladie érythémateuse) ayant frappé les habitants d'Inukjuak dans sa jeunesse.
title: Enoncés spontanés de Rhoda Angatookalook
title: Spontaneous utterances by Rhoda Angatookalook
titleType: AlternativeTitle
Creators: name: Mahieu, Marc-Antoine
name: Pilurtuut, Tukirqi
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Inuktitut (dialecte du Nunavik)
subject: ike

description: Conforms to: oai:crdo.vjf.cnrs.fr:cocoon-49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)
Creators: name: Ebstein, Frédéric
name: Keller, Martin
name: Paschen, Annette
name: Walden, Peter
name: Seeger, Michael
name: Bürger, Elke
name: Krüger, Elke
name: Schadendorf, Dirk
name: Kloetzel, Peter-M.
name: Seifert, Ulrike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Efficient processing of target antigens by the ubiquitin-proteasome-system (UPS) is essential for treatment of cancers by T cell therapies. However, immune escape due to altered expression of IFN-γ-inducible components of the antigen presentation machinery and consequent inefficient processing of HLA- dependent tumor epitopes can be one important reason for failure of such therapies. Here, we show that short-term co-culture of Melan-A/MART-1 tumor antigen-expressing melanoma cells with Melan-A/MART-126-35-specific cytotoxic T lymphocytes (CTL) led to resistance against CTL-induced lysis because of impaired Melan-A/MART-126-35 epitope processing. Interestingly, deregulation of p97/VCP expression, which is an IFN-γ-independent component of the UPS and part of the ER-dependent protein degradation pathway (ERAD), was found to be essentially involved in the observed immune escape. In support, our data demonstrate that re-expression of p97/VCP in Melan-A/MART-126-35 CTL-resistant melanoma cells completely restored immune recognition by Melan-A/MART-126-35 CTL. In conclusion, our experiments show that impaired expression of IFN-γ-independent components of the UPS can exert rapid immune evasion of tumor cells and suggest that tumor antigens processed by distinct UPS degradation pathways should be simultaneously targeted in T cell therapies to restrict the likelihood of immune evasion due to impaired antigen processing.
A critical overview of international law with regard to the problem of terrorism in the aftermath of the September 11, 2001 terrorist attacks
Creators: name: Yoon, Joon Hyuk
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Political Science, International Law and Relations.

description: The terrorist attacks of September 11, 2001 have dramatically shaken world order and altered our perception of terrorism as being a serious threat to the national security of any State. These events are unprecedented in modern history, first, by their sheer magnitude and destructiveness, and also because of the suicidal fanaticism of its perpetrators. Nevertheless, there is a need to explore and analyze some of the international legal issues with regard to the problem of terrorism, especially in the aftermath of the September 11 events. To achieve this, the thesis will first examine the historical and definitional background of the problem of international terrorism. It will then explore the thorny subject of terrorism and State responsibility in order to determine under what circumstances can a State be held internationally liable for the commission of a terrorist act. Finally, in the last part of the thesis, the issue of self-defence against terrorist attacks will be thoroughly analyzed.
An invariant for locally finite dimensional semisimple algebras.
Creators: name: Duong, Hoan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Mathematics.

description: Complete invariants were found for the category of unital direct limits of finite dimensional semisimple complex algebras and the category of unital direct limits of finite dimensional semisimple real algebras by G. A. Elliott ( (E)) and by K. R. Goodearl and D. E. Handelman ( (GH)) respectively. We are naturally led to consider similar complete invariants for other algebras of this type. For other fields, the situation is much more complicated, since the set of division rings containing a field F that is neither real closed nor algebraically closed is infinite (even ignoring the noncommutative ones). So let $\Omega=\{D\sb{i}\}$ be a finite set of finite dimensional division algebras, we shall only study the categories of unital direct limits of finite direct products of matrix algebras involving just this set of division rings. The conjecture of (GH) concerning a proposed complete invariant for direct limit algebras is simplified, and we show that this invariant (essentially a diagram of ordered $K\sb0$-groups) is complete, establishing the conjecture.
ЖАНРОВАЯ СПЕЦИФИКА  ФИЛОСОФСКО- САТИРИЧЕСКОЙ ПРОЗЫ
Creators: name: Алимова, Маъмурахон
Publisher: name: Zenodo
Year: 2024

description: В данной статье рассматривается жанровое своеобразие философско- сатирической прозы, сатирические приёмы, философско-сатирическая проза как особый жанр литературы, который объединяет в себе философские размышления и критическое отношение автора к действительности.
Environmental hazards : The micro-geography of land-use negative externalities
Creators: name: Somerville, Tsur
name: Wetzel, Jake
Publisher: name: The University of British Columbia
Year: 2017

description: The decisions on the siting of hazardous facilities and compensation for nearby landowners depends on an accurate estimation of the negative externalities these facilities place on proximate land uses, primarily residential properties. In this paper we highlight the sensitivity of these estimates to the treatment of distance from the hazard and to the presence of other nearby land uses identified at a highly granular geographic level. Recent opposition to the expansion of North American pipeline capacity has been intense, mixing concerns about climate change, environmental damage, and local opposition to the physical presence of pipelines in their neighbourhoods. This paper studies the disamenity effects associated with the last factor. In doing so we generate results that more broadly address the specification and left out variable bias challenges of measuring the capitalization of negative location-specific environmental externalities. The key contributions of this paper are first showing that disamenity effects can be highly localized and easily susceptible to errors with parametric specifications. Second, that the magnitude of the effect on house prices arising from proximity are sensitive to land uses that are not the hazard in question, but whose presence may be correlated with the hazard. And third, that negative news about a hazard increases the assessment of risk and lowers nearby house values, but that this effect is temporary. We find that the quantitative effects of proximity to oil pipelines are relatively small: prices are lower by 5.7 percent ($39.3k) for properties with a pipeline easement, 2.1 percent ($14.4k) lower for those properties adjacent to a property with an easement, and 1.4 percent ($9.6k) for those adjacent to the former, one property further away from the pipeline. Though this last result is sensitive to specification choice. The prices of all residential properties further away from the pipeline in our data are unaffected. When expressed in cardinal distance, only the prices for residential properties within 100 meters of the pipeline easement are affected. The findings here suggest that care and flexibility with functional forms, the perception of hazards, and attention to land use contexts is necessary for an analysis of the negative externalities for residential property associated with proximity to environmental disamenities and that simple parametric treatments are highly likely to result in biased estimates.
Mass transfer studies in nickel/cobalt separation using pulsed sieve-plate extraction column.
Creators: name: Lee, Johnsee.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1978
Subjects: subject: Engineering, Chemical.

description: Nickel/Cobalt separation was achieved in a pulsed sieve-plate extraction column using di(2-ethyl hexyl) phosphoric acid as the extractant. The liquid-liquid mass transfer involved in this process has been studied. To evaluate the mass transfer characteristics of the operation, steady-state concentration profiles along the column were obtained by sampling both phases from each plate. Droplet size and interfacial area were estimated using a photographic method. From this information, the overall mass transfer coefficients in different sections of the column were calculated, and were found to vary with the concentration during the extraction, but remained rather constant during scrubbing and stripping. The value of the coefficients were in the 0.2 x 10-3 to 1.8 x 10-3cm/sec. range for cobalt, and 0.5 x 10-3 to 2.4 x 10-3cm/sec. for nickel. By applying the pulsing technique to increase the degree of mixing between the two phases, the mass transfer rate was found to be significantly enhanced. The comparison of mass transfer coefficients with values obtained using different pulse amplitudes indicated that the coefficient value increased as the amplitude increased. The coefficient was also observed to be affected by the direction of mass transfer, such that the mass transfer coefficients for extraction were found to be higher than those obtained in stripping.
title: Chant de Kautjajuk aux chiens
title: Kautjajuk's song to the dogs
titleType: AlternativeTitle
Creators: name: Mahieu, Marc-Antoine
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025
Subjects: subject: Inuktitut (dialecte du Nunavik)
subject: ike

description: Conforms to: oai:crdo.vjf.cnrs.fr:cocoon-49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
title: A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites
title: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study
titleType: Subtitle
Creators: name: Patel, Manish V.
name: Patel, Kalapi B.
name: Gupta, Shivenarain
name: Michalsen, Andreas
name: Stapelfeldt, Elmar
name: Kessler, Christian S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Hepatic cirrhosis is one of the leading causes of death worldwide, especially if complicated by ascites. This chronic condition can be related to the classical disease entity jalodara in Traditional Indian Medicine (Ayurveda). The present paper aims to evaluate the general potential of Ayurvedic therapy for overall clinical outcomes in hepatic cirrhosis complicated by ascites (HCcA). In form of a nonrandomized, uncontrolled, single group, open-label observational clinical study, 56 patients fulfilling standardized diagnostic criteria for HCcA were observed during their treatment at the P. D. Patel Ayurveda Hospital, Nadiad, India. Based on Ayurvedic tradition, a standardized treatment protocol was developed and implemented, consisting of oral administration of single and compound herbal preparations combined with purificatory measures as well as dietary and lifestyle regimens. The outcomes were assessed by measuring liver functions through specific clinical features and laboratory parameters and by evaluating the Child-Pugh prognostic grade score. After 6 weeks of treatment and a follow-up period of 18 weeks, the outcomes showed statistically significant and clinically relevant improvements. Further larger and randomized trials on effectiveness, safety, and quality of the Ayurvedic approach in the treatment of HCcA are warranted to support these preliminary findings.
title: CONNECTING TO THE GOOD LIFE
title: A SCOPING REVIEW, MULTIPLE SITE CASE STUDY, AND QUALITATIVE INQUIRY OF OUTDOOR AND LAND-BASED PREVENTION PROGRAMS FOR INDIGENOUS YOUTH
titleType: Subtitle
Creators: name: Price, Faith M.
Publisher: name: Washington State University
Year: 2024
Subjects: Indigenous
intervention
land-based
Native
outdoor
prevention

description: Grassroots outdoor and land-based programs have been developed and implemented in many Indigenous communities, indicating they are a culturally acceptable model for prevention. The literature available on these programs is growing, and outcomes show promise for Indigenous youth wellbeing. More research is needed, however, on how to design, implement and evaluate them. This dissertation aims to add to the knowledge base of prevention programs for Indigenous youth. Manuscript one is a scoping review of outdoor and land-based prevention programs for Indigenous youth that explores the extent of programs that exist, their characteristics, and the degree to which programs have undergone formal research studies. Manuscript two provides case studies of ten diverse, effective, outdoor and land-based programs and further examines common characteristics through an Indigenous framework for wellbeing. Lastly, manuscript three is a qualitative study of youth and parent perceptions of the core components of an outdoor program for Indigenous youth. The findings of these three studies may be a guide for Indigenous communities that seek to develop programs to promote the wellbeing of their youth.
Stellar population gradients and spatially resolved kinematics in luminous post-starburst galaxies
Creators: name: Pracy, M. B.
name: Croom, S.
name: Sadler, E.
name: Couch, Warrick
name: Kuntschner, H.
name: Bekki, K.
name: Owers, M. S.
name: Zwaan, M.
name: Turner, J.
name: Bergmann, M.
Publisher: name: Swinburne
Year: 2024

description: We have used deep integral field spectroscopy obtained with the Gemini Multi-Object Spectrograph (GMOS) instrument on Gemini-North to determine the spatial distribution of the post-starburst stellar population in four luminous (∼L*) E+A galaxies at z < 0.04. We find that all four galaxies have centrally concentrated gradients in the young stellar population contained within the central ∼1 kpc. This is in agreement with the Balmer line gradients found in local low-luminosity E+A galaxies. The results from higher redshift (z ∼ 0.1) samples of luminous E+A galaxies have been varied, but in general have found the post-starburst signature to be extended or a galaxy-wide phenomenon or have otherwise failed to detect gradients in the stellar populations. The ubiquity of the detection of a centrally concentrated young stellar population in local samples, and the presence of significant radial gradients in the stellar populations when the E+A galaxy core is well resolved raises the possibility that spatial resolution issues may be important in interpreting the higher redshift results. The two early-type E+A galaxies in our sample that can be robustly kinematically classified, using the λR parameter, are fast rotators. Combined with previous measurements, this brings the total number of E+A galaxies with measurements of λR to 26, with only four being classified as slow rotators. This fraction is similar to the fraction of the early-type population as a whole and argues against the need for major mergers in the production of E+A galaxies, since major mergers should result in an increased fraction of slow rotators.
Microcalorimetric investigations: Part I. Construction of a microcalorimeter for heats of combustion. Part II. Heats and entropies of ionization of some anilines.
Creators: name: Zawidzki, Tadeusz W.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1958
Subjects: subject: Chemistry, Analytical.

description: A microcalorimeter of the Tian-Calvet type has been constructed for the purpose of measuring heats of combustion. The instrument consists of a differentially-connected system of two iron-constantan thermopiles, each being constructed of sixteen thermocouples. The recording of the heat liberated is accomplished by means of a d.c. amplifier; the areas thus recorded are integrated by an electronic integrator. The apparatus is capable of measuring heats of the order of 10-3cal. The microcalorimeter is discussed from the theoretical and practical points of view.
3287807.pdf
Creators: name: Atzeni, Simone
name: Rab, Syed Adil
name: Corrielli, Giacomo
name: Polino, Emanuele
name: Valeri, Mauro
name: Mataloni, Paolo
name: Spagnolo, Nicolo
name: Crespi, Andrea
name: Sciarrino, Fabio
name: Osellame, Roberto
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Extended description of device fabrication and characterization
Decentralized coordination building blocks (DCBlocks) for decentralized monitoring and control of smart power grids
Creators: name: Niddodi, Shwetha
Publisher: name: Washington State University
Year: 2015
Subjects: Electric power distribution--Management
Smart power grids
Decentralized--power--control--DCBlocks--grid--monitoring--failure--'power system'

description: Decentralized Coordination (DC) algorithms for distributed systems are widely used in many applications such as online banking, online shopping, the internet and many more. Here, the processes spread apart in a network coordinate with each other to achieve a common application specific task. DC algorithms are also applicable to wide range of large scale engineering system infrastructure. One such critical engineering infrastructure is the power grid. The common control architecture in traditional power grids for power system monitoring and control has been central control center based (CC), complemented with limited local control. However, with the ongoing and future transitions to the smart electric power grid, the CC based control is becoming unsuitable for the grid’s changing demands. Smart field sensors, renewable energy sources and more Information and Communications Technology methods are being used for monitoring and control. The need for supplementing the conventional CC based power system control to a more decentralized power system control is being advocated. However, the research is mostly in developing decentralized power algorithms. This change need to be supported with robust decentralized computing and communication infrastructure. Many DC algorithms along with different failure models supported by them have been studied and applied for more than three decades. These algorithms can used to provide a robust, fault tolerant solution for developing decentralized power algorithms. This research involves survey of existing and emerging decentralized power applications and survey of various DC algorithms available in computer literature that would be most suitable for these decentralized power applications. Design of Decentralized Coordination Building Blocks (DCBlocks) based on these DC algorithms which can act as a software platform for developing robust power applications is discussed. Few use cases of decentralized power applications using DCBlocks have been provided to show applicability of DCBlocks to a wide spectrum of power system scenarios. A prototype implementation of one of the decentralized power application using DCBlocks platform is demonstrated. Experiments are conducted using wide scale test bed environment like DeterLab for profiling the performance of DCBlocks.