title: ÐÑÐµÐ½ÐºÐ° Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð° Ð² Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¾ÑÑ Ð¾Ð´Ð°Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¿Ð¾ÑÐ»Ðµ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ñ 225Ac-PSMA Ð¸ 225Ac-DOTA-TATE
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Assessment of radionuclide activity in biological waste of patients after radionuclide therapy with 225Ac-PSMA and 225Ac-DOTA-TATE
Creators: name: ÐÐ¾ÑÑÐ½Ð¾Ð², ÐÑÑÑÐ¼
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
225Ac
PSMA
DOTA-TATE
ÐÐ¤Ð­ÐÐ¢
radionuclide therapy
SPECT

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ» Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ Ð²ÑÐ²Ð¾Ð´Ð¸Ð¼Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾ÑÐ»Ðµ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ñ 225Ac-PSMA Ð¸ 225Ac-DOTA-TATE. Ð Ð°ÑÑÐµÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð¸Ð»ÑÑ Ð´Ð²ÑÐ¼Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð°Ð¼Ð¸: Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð¼ÐµÑÑÐ¸Ð¸ Ð¾ÑÑÐ¾Ð´Ð¾Ð² Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð² ÑÑÐ¾Ðº Ð´Ð¾ 72 ÑÐ°ÑÐ¾Ð² Ð¿Ð¾ÑÐ»Ðµ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð±ÑÐ°Ð»Ð¸ Ð¿ÑÐ¾Ð±Ñ Ð¼Ð¾ÑÐ¸ Ð¸ ÐºÑÐ¾Ð²Ð¸, Ð´Ð»Ñ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ ÑÐ´ÐµÐ»ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð² Ð¿ÑÐ¾Ð±Ð°Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»ÑÑ Ð¿Ð¾Ð»ÑÐ¿ÑÐ¾Ð²Ð¾Ð´Ð½Ð¸ÐºÐ¾Ð²ÑÐ¹ Ð³Ð°Ð¼Ð¼Ð°-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑ ORTEC, Ð¼Ð¾Ð´ÐµÐ»Ð¸ TSP-DX-100T-PAC-PKG-1, ÑÐ°ÐºÐ¶Ðµ ÑÐ°ÑÑÐµÑ Ð²ÑÐ²Ð¾Ð´Ð¸Ð¼Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»ÑÑ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð¼ÐµÑÑÐ¸Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¿Ð¾ÑÐ»Ðµ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ñ 225Ac-DOTA-TATE, ÑÐºÐ°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð½Ð° Ð¾Ð´Ð½Ð¾ÑÐ¾ÑÐ¾Ð½Ð½Ð¾Ð¼ ÑÐ¼Ð¸ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½Ð¾Ð¼ ÑÐ¾Ð¼Ð¾Ð³ÑÐ°ÑÐµ(ÐÐ¤Ð­ÐÐ¢) Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ 5 ÑÐ°Ð· Ð´Ð»Ñ ÐºÐ°Ð¶Ð´Ð¾Ð³Ð¾ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ°, ÑÑÐ°Ð·Ñ Ð¿Ð¾ÑÐ»Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ, ÑÐµÑÐµÐ· 4, 24, 48 Ð¸ 72 ÑÐ°ÑÐ° Ð¿Ð¾ÑÐ»Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ. Ð£Ð´ÐµÐ»ÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ, Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½Ð°Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ°Ð´Ð¸Ð¾Ð¼ÐµÑÑÐ¸Ð¸ Ð¾ÑÑÐ¾Ð´Ð¾Ð² Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð², Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ðº Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐµÑÐµÐ· Ð¸Ð·Ð²ÐµÑÑÐ½ÑÐ¹ Ð¾Ð±ÑÑÐ¼ Ð½Ð° Ð¼Ð¾Ð¼ÐµÐ½Ñ Ð·Ð°Ð±Ð¾ÑÐ° Ð´Ð»Ñ Ð¿ÑÐ¾Ð± Ð´Ð¾ 4 ÑÐ°ÑÐ¾Ð², Ð° Ð´Ð°Ð»ÐµÐµ ÑÐµÑÐµÐ· ÑÐ¼Ð½Ð¾Ð¶ÐµÐ½Ð¸Ðµ Ð½Ð° ÑÑÐ°Ð»Ð¾Ð½Ð½ÑÐ¹ Ð¾Ð±ÑÑÐ¼ Ð¼Ð¾ÑÐ¸ Ð·Ð° ÑÑÑÐºÐ¸. ÐÐ»Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð²ÑÐ²ÐµÐ´ÐµÐ½Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÐÐ¤Ð­ÐÐ¢ Ð¸Ð·Ð¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ð¹ ÑÑÐ¸ÑÐ°Ð»Ð¸ÑÑ ÐºÐ°ÑÐ½ÑÑ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ðµ MicroDICOM, Ð° Ð¿Ð¾ÑÐ»Ðµ, Ð¿Ð¾ ÑÐ¾ÑÐ¼ÑÐ»Ð°Ð¼ Ð¸Ð· Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½ÑÑ Ð¸ÑÑÐ¾ÑÐ½Ð¸ÐºÐ¾Ð², ÐºÐ°ÑÐ½ÑÑ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ð»Ð¸ÑÑ Ðº Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿Ð¾Ð´Ð²ÐµÑÐ³Ð°Ð»Ð¸ÑÑ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ðµ StatSoft STATISTICA. Ð Ð°ÑÑÑÐ¸ÑÐ°Ð½Ð½ÑÐµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¾ Ð²ÑÐ²ÐµÐ´ÐµÐ½Ð½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ Ð² Ð¾ÑÑÐ¾Ð´Ð°Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¼Ð¾Ð¶Ð½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð´Ð»Ñ ÑÑÐ¾ÑÐ½ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²ÑÐ²ÐµÐ´ÐµÐ½Ð¸Ñ 225ÐÑ Ð¸Ð· Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¼Ð° Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¿Ð¾ÑÐ»Ðµ Ð ÐÐ¢, ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¾ÑÑÐ¾Ð´Ð¾Ð² Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¸ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾Ð±ÑÐ°ÑÐµÐ½Ð¸Ñ Ñ Ð½Ð¸Ð¼Ð¸ Ð² Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸ÑÑ.
description: In this work, the excreted activity was calculated after radionuclide therapy with 225Ac-PSMA and 225Ac-DOTA-TATE. The calculation was carried out in two ways: based on the radiometry of patient waste, urine and blood samples were taken from patients up to 72 hours after therapy; an ORTEC semiconductor gamma spectrometer, model TSP-DX-100T-PAC-PKG-1, was used to measure the specific activity in the samples. Also, the calculation of excreted activity was carried out based on radiometry of patients after radionuclide therapy with 225Ac-DOTA-TATE, SPECT scanning was performed 5 times for each patient, immediately after injection, 4,24,48 and 72 hours after injection. The specific activity derived from patient waste radiometry was converted to activity through a known volume at the time of sampling for up to 4 hours, and then multiplied by the reference volume of urine per day. To obtain the derived activity based on SPECT images, the counts were counted in the MicroDICOM program, and then, according to the formulas from the literature, the counts were reduced to activity. The obtained activities were compared in the StatSoft STATISTICA program. The calculated experimental data of the excreted activities in patient waste can be used to refine the model of 225Ac excretion from the body of patients after RNT, classify the biological waste of patients, and plan their handling in medical organizations.