cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Retrovirus-mediated gene transfer to cystic fibrosis airway epithelial cells: effect of selectable marker sequences on long-term expression
Creators: name: Olsen, John C.
name: Boucher, Richard C.
name: Johnson, Larry G.
name: Swanstrom, Ronald
name: Moore, Karen L.
name: Wong-sun, Mabel L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: Retrovirus-mediated gene transfer offers the potential for stable long-term expression of transduced genes in host cells subsequent to integration of vector DNA into the host genome. Using a murine amphotropic retrovirus vector containing an interleukin-2 receptor (IL-2R) gene as a reporter and a neomycin phosphotransferase (
Additional file 1 of Radiomics predictive modeling from dual-time-point FDG PET Ki parametric maps: application to chemotherapy response in lymphoma
Creators: name: Samimi, Rezvan
name: Shiri, Isaac
name: Ahmadyar, Yashar
name: van den Hoff, Jörg
name: Kamali-Asl, Alireza
name: Rezaee, Alireza
name: Yousefirizi, Fereshteh
name: Geramifar, Parham
name: Rahmim, Arman
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
subject: Ecology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
classificationCode: 19999
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Additional file 1: Figure S1. Shows the univariate AUC, p-values, and q-values heat map of DTP and static features with and without Combat harmonizations. Figure S2. Shows univariate Delong test p-values and q-values comparing the performance of combat harmonization in static and DTP features with and without Combat harmonization. Differences with p and q < 0.05 are considered statistically significant and highlighted in purple.
Коммуникативные неудачи в дубляже как следствие ошибок на уровне просодии
Creators: name: Сообщество рецензентов Международного научно-исследовательского журнала
Publisher: name: ООО Цифра
Year: 2024
Subjects: dubbing
intonation
melody
synergy
verbal context
situational context
дубляж
интонация
мелодика
синергия
вербальный контекст
ситуативный контекст

description: Russian Linguistic Bulletin, Выпуск 9 (57) 2024
(400080) Margaret Maddison
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Electromagnetic Scattering by Spheres of Topological Insulators
Creators: name: Ge, Lixin
name: Han, Dezhuan
name: Zi, Jian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The electromagnetic scattering properties of topological insulator (TI) spheres are systematically studied in this paper. Unconventional backward scattering caused by the topological magneto-electric (TME) effect of TIs are found in both Rayleigh and Mie scattering regimes. This enhanced backward scattering can be achieved by introducing an impedance-matched background which can suppress the bulk scattering. For the cross-polarized scattering coefficients, interesting antiresonances are found in the Mie scattering regime, wherein the cross-polarized electromagnetic fields induced by the TME effect are trapped inside TI spheres. In the Rayleigh limit, the quantized TME effect of TIs can be determined by measuring the electric-field components of scattered waves in the far field.
description: 13 pages, 4 figures
(400083) Anne Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary tables, figures and references from High species richness and lineage diversity of reef corals in the mesophotic zone.
Creators: name: Muir, Paul R.
name: Carden C. Wallace
name: Pichon, Michel
name: Bongaerts, Pim
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Coral reefs are increasingly threatened by thermal bleaching and tropical storm events associated with rising sea surface temperatures. Deeper habitats offer some protection from these impacts and may safeguard reef-coral biodiversity, but their faunas are largely undescribed for the Indo-Pacific. Here, we show high species richness of scleractinian corals in mesophotic habitats (30–125 m) for the northern Great Barrier Reef region that greatly exceeds previous records for mesophotic habitats globally. Overall, 45% of shallow reef species (less than or equal to 30 m), 78% of genera and all families extended below 30 m depth, with 13% of species, 41% of genera and 78% of families extending below 45 m. Maximum depth of occurrence showed a weak relationship to phylogeny, but a strong correlation with maximum latitudinal extent. Species recorded in the mesophotic had a significantly greater than expected probability of also occurring in shaded microhabitats and at higher latitudes, consistent with light as a common limiting factor. The findings suggest an important role for deeper habitats, particularly depths 30–45 m, in preserving evolutionary lineages of Indo-Pacific corals. Deeper reef areas are clearly more diverse than previously acknowledged and therefore deserve full consideration in our efforts to protect the world's coral reef biodiversity.
Rapid pulsed field separation of DNA molecules up to 250 kb
Creators: name: Lai, Eric
name: Birren, Bruce
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: Pulsed field gel electrophoresis (PFGE) Is capable of resolving a wide size range of DNA molecules which would all co-migrate in conventional agarose gels. We describe pulsed field gel conditions which permit DNA fragments of up to 250 kllobases (kb) to be separated in only 3.5 h. The separations, which employ commercially available gel boxes, are achieved using conditions which deviate significantly from traditional pulsed field conditions. PFGE separations have been thought to require reorientation angles greater than 90° to be effective. However, reorientation angles of 90° and even less will resolve DNA fragments a few hundred kb and smaller ∑5 × faster than with standard pulsed field conditions. The mobility of DNA fragments separated with 90° reorientation angles Is switch time-dependent, as is seen for DNA run with the commonly used reorientation angle of 120°. With DNA fragments of several hundred kb and smaller, higher field strengths may be used, resulting in still greater increases in separation speed. The conditions described allow DNA from large Insert bacterial clones, such as those using cosmld, Fosmld, P1, bacterial artificial chromosome (BAC), or P1-derived artificial chromosome (PAC) vectors, to be prepared, digested and analyzed on gels within a single working day.
(400078) Ann Ruthven Leven
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Stadtarchivar Eugen Hermann, 21. Januar 1877 - 2. August 1953
title: Trauerfeier in der Friedhofkapelle Manegg, Mittwoch, 5. August 1953
titleType: Subtitle
Creators: name: Briner, Jean
name: Waser, Hans
name: Trachsler, Eugen
Publisher: name: Stadtarchiv
Year: 1954
Subjects: subject: 020 Bibliotheks- und Informationswissenschaften
subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Hermann, Eugen
subject: Zürich

description: Inhalt: Abschiedsworte von Herrn a. Stadtrat Jean Briner ; Abschiedsworte von Herrn Stadtarchivar Dr. Hans Waser ; Abschiedsworte von Herrn Lehrer Eugen Trachsler ; zwei Nekrologe aus Zeitungen
Additional file 1 of Genetic dissection of root architectural plasticity and identification of candidate loci in response to drought stress in bread wheat
Creators: name: Siddiqui, Nurealam
name: Gabi, Melesech T.
name: Kamruzzaman, Mohammad
name: Ambaw, Abebaw M.
name: Teferi, Tesfaye J.
name: Dadshani, Said
name: Léon, Jens
name: Ballvora, Agim
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Supplementary Material 1
SZZ in the Time of Pull Requests - Replication Package
Creators: name: Petrulio, Fernando
Publisher: name: figshare
Year: 2022
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: This replication package contains:
- The source code used to run SZZ- Analyzed and raw results from SZZ- The dataset used for the research project

The package contains also a README.md file with instructions needed for package exploration.
Maximal displacement of a supercritical branching random walk in a time-inhomogeneous random environment
Creators: name: Mallein, Bastien
name: Miłoś, Piotr
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60J80

description: The behavior of the maximal displacement of a supercritical branching random walk has been a subject of intense studies for a long time. But only recently the case of time-inhomogeneous branching has gained focus. The contribution of this paper is to analyze a time-inhomogeneous model with two levels of randomness. In the first step a sequence of branching laws is sampled independently according to a distribution on the set of point measures' laws. Conditionally on the realization of this sequence (called environment) we define a branching random walk and find the asymptotic behavior of its maximal particle. It is of the form $V_n -φ\log n + o_\mathbf{P}(\log n)$, where $V_n$ is a function of the environment that behaves as a random walk and $φ>0$ is a deterministic constant, which turns out to be bigger than the usual logarithmic correction of the homogeneous branching random walk.
description: Updated version with corrected typos, Stochastic Process. Appl. (2018)
(400081) Robert Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1
Creators: name: Swanstrom, Ronald
name: Kaplan, Andrew H.
name: Hutchison, Clyde A.
name: Juranka, Peter
name: Chan, Voon Loong
name: Chao, Shih fong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: ABSTRACT We have analyzed 154 single amino acid replacement mutants within a 40 amino acid region (residues 164–203) of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). This region consists of two antiparallel β-strands (strands 9 and 10) flanked by two α helices (E and F). The structure of this region of the ‘palm’ subdomain is conserved in a variety of DNA and RNA polymerases, indicating a critical role in enzyme structure and function. Functional assays were performed by screening RT activity of mutants expressed in E.coli.A functionally important region corresponding closely to β-strands 9 and 10 and the loop joining them was revealed by its mutational sensitivity. Structural analysis of mutants was performed by using Western blots to assay correct folding, which is required for processing to produce the mature p66 and p51 RT species. This analysis indicates that β-strand 10 is a structurally important region. Combined analysis of these two assays revealed diagnostic patterns of mutational sensitivity which identify key positions in the RT sequence at which a specific amino acid side chain is critical, either for structure or function, as well as residues which are external to the RT structure. This work illustrates the utility of large-scale mutagenesis in relating primary sequence to significant features of protein structure and function.
Supplementary tables, figures and references from High species richness and lineage diversity of reef corals in the mesophotic zone
Creators: name: Muir, Paul R.
name: Carden C. Wallace
name: Pichon, Michel
name: Bongaerts, Pim
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Coral reefs are increasingly threatened by thermal bleaching and tropical storm events associated with rising sea surface temperatures. Deeper habitats offer some protection from these impacts and may safeguard reef-coral biodiversity, but their faunas are largely undescribed for the Indo-Pacific. Here, we show high species richness of scleractinian corals in mesophotic habitats (30–125 m) for the northern Great Barrier Reef region that greatly exceeds previous records for mesophotic habitats globally. Overall, 45% of shallow reef species (less than or equal to 30 m), 78% of genera and all families extended below 30 m depth, with 13% of species, 41% of genera and 78% of families extending below 45 m. Maximum depth of occurrence showed a weak relationship to phylogeny, but a strong correlation with maximum latitudinal extent. Species recorded in the mesophotic had a significantly greater than expected probability of also occurring in shaded microhabitats and at higher latitudes, consistent with light as a common limiting factor. The findings suggest an important role for deeper habitats, particularly depths 30–45 m, in preserving evolutionary lineages of Indo-Pacific corals. Deeper reef areas are clearly more diverse than previously acknowledged and therefore deserve full consideration in our efforts to protect the world's coral reef biodiversity.
Mid-Time report detailing the new experimental facility and results from the theoritical studies
Creators: name: C. Pedano
name: L. Contiero
Publisher: name: Zenodo
Year: 2023
Subjects: WP10

description: This report describes the activities performed so far according to the plan for task 10.4:” Supercritical fluids as refrigerants”. The project aims at defining the feasibility of future detector cooling systems based on refrigerant in supercritical state. The present document summarises the main achievements at this stage: Review of the literature available regarding thermal efficiency studies with carbon dioxide at supercritical state. Selection of the best suited supercritical refrigerant candidate for low temperature applications. Final designs of two dedicated test stands and description of the processes.
Physical and functional interaction of the Epstein-Barr virus BZLF1 transactivator with the retinoic acid receptors RAR  and RXR
Creators: name: Barry, Christopher
name: Pagano, Joseph
name: Sampson, Kimberly
name: Deshmane Sista, Nirupama
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Epstein-Barr virus (EBV) reactivation, indicated by induction of EBV early antigens from latently Infected lymphoid cell lines by phorbol esters, Is inhibited by retinoic acid (RA). Viral reactivation, which Is triggered by the immediate-early BZLF-1 (Z) viral gene product, is repressed by retinoic acid receptors (RARs) RARα and RXRα. These proteins negatively regulate Z-mediated transactlvation of the promoter for an EBV early gene product, early antigen-diffuse (EaD). Here we confirm a direct physical interaction between the AP1-llke protein Z and RXRα and map the domains of Interaction In the Z protein and RXRα. The domain required for homodimerlzation of Z is separate from that required for its interaction with RXRα. Z also has the effect of repressing activation of an RAR-respon-slve cellular promoter (BRE). Point mutants In the dimerlzation domain of Z unable to interact with RXRα do not repress RXRα-medlated transactivation of BRE, the promoter for RARβ, which suggests that Interaction between the two proteins is required for this repressor effect. The domain of RXRα required for interaction with Z has been mapped, and is again separate from that required for homodimerization. These results indicate that a ‘cross-coupling’ or direct interaction between Z and RARα and RXRα can modulate the reactivation of latent EBV infection and suggest that, reciprocally, the viral protein Z may influence cellular regulatory pathways.
Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage
Creators: name: Smith, Frances W.
name: Ferris, Robert
name: Sancar, Gwendolyn B.
name: Vandeberg, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The PHR1 gene of
3' Processing and termination of mouse histone transcripts synthesized in vitro by RNA polymerase II
Creators: name: Gu, Xiaohong
name: Marzluff, William R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The highly expressed mouse histone H2a-614 gene is located 800 nt 5' of the histone H3-614 gene. There is a 140 nt sequence located 500 nt from the end of the H2-614 mRNA which has been defined as a transcription termination site for RNA polymerase II. We established an in vitro transcription system in which both 3' end processing and transcription termination occur. A template containing the adenovirus major late promoter, a portion of the histone H2a-614 coding region, its 3' processing signal, followed by the transcription termination site was transcribed in a nuclear extract prepared from mouse myeloma cells. Some of the transcripts synthesized in the extract were cleaved at the histone processing site in a reaction which was dependent both on the hairpin binding factor and the U7 snRNP. The efficiency of histone 3' end formation was similar both on synthetic transcripts and transcripts synthesized by RNA polymerase II. Defined transcripts, which were not processed and which mapped to the transcription termination site, were released from the template, suggesting that they were formed by transcription termination. Termination in vitro was dependent on a functional histone processing signal.
Effects on NaeI-DNA recognition of the leucine to lysine substitution that transforms restriction endonuclease NaeI to a topoisomerase: a model for restriction endonuclease evolution
Creators: name: Jo, Kiwon
name: Topal, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Substituting lysine for leucine at position 43 (L43K) transforms NaeI from restriction endonuclease to topoisomerase and makes NaeI hypersensitive to intercalative anticancer drugs. Here we investigated DNA recognition by Nael-L43K. Using DNA competition and gel retardation assays, NaeI-L43K showed reduced affinity for DNA substrate and the ability to bind both single- and double-stranded DNA with a definite preference for the former. Sedimentation studies showed that under native conditions NaeI-L43K, like NaeI, is a dimer. Introduction of mismatched bases into double-stranded DNA significantly increased that DNA's ability to inhibit NaeI-L43K. Wild-type NaeI showed no detectable binding of either single-stranded DNA or mismatched DNA over the concentration range studied. These results demonstrate that the L43K substitution caused a significant change in recognition specificity by NaeI and imply that NaeI-L43K's topoisomerase activity is related to its ability to bind single-stranded and distorted regions in DNA. A mechanism is proposed for the evolution of the NaeI restriction-modification system from a topoisomerase/ligase by a mutation that abolished religation activity and provided a needed change in DNA recognition.
Incomplete Factorial and Response Surface Methods in Experimental Design: Yield Optimization of tRNATrp from In vitro T7 RNA Polymerase Transcription
Creators: name: Carter Jr., Charles W.
name: Yin, Yuhui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: We have studied the yield of Escherichia coli tRNA(Trp) obtained from in vitro T7 RNA polymerase transcription using incomplete factorial and response surface methods. Incomplete factorial experiments were first used to estimate the relative impact of six variables on the yield of tRNA(Trp). Fifteen trials were performed according to a balanced and randomized design. The correlation between observed yield and all experimental variables was identified by stepwise multiple linear regression analysis. The concentrations of T7 RNA polymerase, DNA template, NTP and MgCl2 proved to be significantly correlated with the yield of tRNA(Trp). We then optimized the yield with respect to each of these four variables simultaneously with a designed, response surface experiment based on the Hardin-Sloane minimum prediction variance algorithm. Twenty experiments were performed, in duplicate, to sample the quadratic surface relating the yield to the four significant variables. Coefficients of the quadratic function with all two-factor interactions were evaluated by stepwise regression using least squares, and significant coefficients were retained. Partial differentiation of the resulting quadratic model showed it to possess an optimum. Transcription performed at the corresponding conditions yielded 6-fold more tRNA(Trp) than the initial conditions, confirming the predictive value of the experimentally determined response surface.
Increasing the Distance Between the snRNA Promoter and the 3' Box Decreases the Efficiency of snRNA 3-End Formation
Creators: name: Ingledue, Thomas C.
name: Marzluff, William F.
name: Kay, Brian K.
name: Ramamurthy, Lakshman
name: Pilch, Duane R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Chimeric genes which contained the mouse U1b snRNA promoter, portions of the histone H2a or globin coding regions and the U1b 3'-end followed by a histone 3'-end were constructed. The distance between the U1 promoter and the U1 3' box was varied between 146 and 670 nt. The chimeric genes were introduced into CHO cells by stable transfection or into Xenopus oocytes by microinjection. The efficiency of utilization of the U1 3' box, as measured by the relative amounts of transcripts that ended at the U1 3' box and the histone 3'-end, was dependent on the distance between the promoter and 3'-end box. U1 3'-ends were formed with >90% efficiency on transcripts shorter than 200 nt, with 50-70% efficiency on transcripts of 280-400 nt and with only 10-20% efficiency on transcripts >500 nt. Essentially identical results were obtained after stable transfection of CHO cells or after injecting the genes into Xenopus oocytes. The distance between the U1 promoter and the U1 3' box must be
Additional file 1 of Radiotherapy-induced diffuse myocardial fibrosis in early-stage breast cancer patients – multimodality imaging study with six-year follow-up
Creators: name: Moisander, Mikko
name: Skyttä, Tanja
name: Kivistö, Sari
name: Huhtala, Heini
name: Nikus, Kjell
name: Virtanen, Vesa
name: Kellokumpu-Lehtinen, Pirkko-Liisa
name: Raatikainen, Pekka
name: Tuohinen, Suvi
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Space Science
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. The integrated backscatter off-line analysis.
Spin-orbit interactions of light
Creators: name: Bliokh, K. Y.
name: Rodriguez-Fortuno, F. J.
name: Nori, F.
name: Zayats, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Light carries spin and orbital angular momentum. These dynamical properties are determined by the polarization and spatial degrees of freedom of light. Modern nano-optics, photonics, and plasmonics, tend to explore subwavelength scales and additional degrees of freedom of structured, i.e., spatially-inhomogeneous, optical fields. In such fields, spin and orbital properties become strongly coupled with each other. We overview the fundamental origins and important applications of the main spin-orbit interaction phenomena in optics. These include: spin-Hall effects in inhomogeneous media and at optical interfaces, spin-dependent effects in nonparaxial (focused or scattered) fields, spin-controlled shaping of light using anisotropic structured interfaces (metasurfaces), as well as robust spin-directional coupling via evanescent near fields. We show that spin-orbit interactions are inherent in all basic optical processes, and they play a crucial role at subwavelength scales and structures in modern optics.
description: 23 pages, 6 figures. Comments welcome
The DNA-binding Protein Hdf1p (a Putative Ku Homologue) Is Required for Maintaining Normal Telomere Length in Saccharomyces Cerevisiae
Creators: name: Ritchie, Kim B.
name: Greenwell, Patricia W.
name: Petes, Thomas D.
name: Porter, Stephanie E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: In mammalian cells, the Ku autoantigen is an end- binding DNA protein required for the repair of DNA breaks [Troelstra, C. and Jaspers, N.G.J. (1994) Curr. Biol., 4, 1149- 1151]. A yeast gene (HDF1) encoding a putative homologue of the 70 kDa subunit of Ku has recently been identified [Feldmann, H. and Winnacker, E. L. (1993) J. Biol. Chem., 268, 12895- 12900]. We find that hdf1 mutant strains have substantially shorter telomeres than wild-type strains. We speculate that Hdf1p may bind the natural ends of the chromosome, in addition to binding to the ends of broken DNA molecules. Strains with both an hdf1 mutation and a mutation in TEL 1 (a gene related to the human ataxia telangiectasia gene) have extremely short telomeres and grow slowly.
Supplementary Tables, Figures and Methods from Insulin signalling's role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus.
Creators: name: Casasa, Sofia
name: Moczek, Armin P.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology

description: Includes Tables S1-S3, Figures S1-S7, Supplementary Methods and References for Supplementary Methods
(400075) Alfred John Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The effects of multi-layer governance on risk disclosures: EU evidence
Creators: name: Khalifa, Aya
Publisher: name: University of Westminster
Year: 2022

description: Disclosure of risks provides information on current and potential risks that firms are facing that may affect their continuity, which is a critical issue for stakeholders. Despite this, most studies examining the impact of firm-level governance structures on risk disclosure are generally rare and focus only on a single country and the amount of information disclosed. Consequently, this study examines how corporate governanceis related to the quantity and quality of risk disclosure by EU firms and whether national governance quality (NGQ) reinforces this relationship. Using one of the largest datasets of corporate governance and risk disclosures to date, research sample includes 4851 observations from firms in the UK, Germany, France, and Italy,covering the period 2012-2018. In this study, an automated content analysis method is used to measure the quantity and quality of risk disclosure practices. The estimation results indicate that firms report risk disclosures with a large degree of variability and inconsistency. In addition, risk disclosures tended to be qualitative, positive, and historical during the seven-year period covered. Furthermore, the multivariate analysis indicates that independent directors, board gender diversity, female leadership, audit quality, institutional ownership, and corporate governance quality are positively associated with the extent and quality of risk disclosures at the firm level. In contrast, concentrated ownership and managerial ownership are negatively related to the extent and quality of risk disclosures. At the country level, the evidence suggests that the NGQ, particularly voice and accountability, control of corruption, and government effectiveness, have a positive impact on risk disclosure. Furthermore, theresults indicate that NGQ has a moderating effect on the relationship between corporate governance and risk disclosures. These findings are largely consistent with the multi-theoretical framework that has been adopted, which integrates agency, resource-dependence, stakeholder, legitimacy and institutional theories. Overall, the results suggestthat firms' disclosure decisions are not only influenced by firm-level governance, but also by country-level governance structures. This study has important implications for firms, policymakers, and other stakeholders in regard to the development of the firm and national governance.
The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells
Creators: name: Gallie, Daniel R.
name: Marzluff, William F.
name: Lewis, Nancy J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The metazoan cell cycle-regulated histone mRNAs are the only known cellular mRNAs that do not terminate in a poly(A) tall. Instead, mammalian histone mRNAs terminate in a highly conserved stem-loop structure which is required for 3'-end processing and regulates mRNA stability. The poly(A) tail not only regulates translational efficiency and mRNA stability but is required for the function of the cap in translation (m(7)GpppN). We show that the histone terminal stem-loop is functionally similar to a poly(A) tail in that it enhances translational efficiency and is co-dependent on a cap in order to establish an efficient level of translation. The histone stem-loop is sufficient and necessary to increase the translation of reporter mRNA in transfected Chinese hamster ovary cells but must be positioned at the 3'-terminus in order to function optimally. Mutations within the conserved stem or loop regions reduced its ability to facilitate translation. All histone mRNAs in higher plants are polyadenylated. The histone stem-loop did not function to influence translational efficiency or mRNA stability in plant protoplasts. These data demonstrate that the histone stem/loop directs efficient translation and that it is functionally analogous to a poly(A) tail.
СПЕЦИФИКА КОММЕНТАРИЕВ В КИБЕРСПОРТИВНОМ ДИСКУРСЕ: МЕЖЪЯЗЫКОВЫЕ АСПЕКТЫ
Creators: name: Сообщество рецензентов Международного научно-исследовательского журнала
Publisher: name: ООО Цифра
Year: 2024
Subjects: сybersport
communication
internationality
slang
online gaming
discourse
sport
vocabulary
terminology
language
markers
mechanics
topography
role
Russification
киберспорт
коммуникация
интернациональность
сленг
онлайн-игры
дискурс
спорт
лексика
терминология
язык
маркеры
механика
топография
роль
русификация

description: Russian Linguistic Bulletin, Выпуск 9 (57) 2024
Enhancing parameter precision of optimal quantum estimation by direct quantum feedback
Creators: name: Zheng, Qiang
name: Ge, Li
name: Yao, Yao
name: Zhi, Qi-jun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Various schemes have been proposed to overcome the drawback of the decoherence on quantum-enhanced parameter estimation. Here we suggest an alternative method, quantum feedback, to enhance the parameter precision of optimal quantum estimation of a dissipative qubit by investigating its dynamics of quantum Fisher information. We find that compared with the case without feedback, the quantum Fisher information of the dissipative qubit in the case of feedback has a large maximum value in time evolution and a smaller decay rate in the long time.
description: 6 pages, 8 figures, accepted for publication in Physical Review A
Resolving Boosted Jets with XCone
Creators: name: Thaler, Jesse
name: Wilkason, Thomas F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We show how the recently proposed XCone jet algorithm smoothly interpolates between resolved and boosted kinematics. When using standard jet algorithms to reconstruct the decays of hadronic resonances like top quarks and Higgs bosons, one typically needs separate analysis strategies to handle the resolved regime of well-separated jets and the boosted regime of fat jets with substructure. XCone, by contrast, is an exclusive cone jet algorithm that always returns a fixed number of jets, so jet regions remain resolved even when (sub)jets are overlapping in the boosted regime. In this paper, we perform three LHC case studies---dijet resonances, Higgs decays to bottom quarks, and all-hadronic top pairs---that demonstrate the physics applications of XCone over a wide kinematic range.
description: 36 pages, 25 figures, 1 table; v2: references added; v3: discussion added and new appendix B to match JHEP version
(400076) Robina Margaret Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Tables, Figures and Methods from Insulin signalling's role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus
Creators: name: Casasa, Sofia
name: Moczek, Armin P.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology

description: Includes Tables S1-S3, Figures S1-S7, Supplementary Methods and References for Supplementary Methods
Additional file 2 of Radiotherapy-induced diffuse myocardial fibrosis in early-stage breast cancer patients – multimodality imaging study with six-year follow-up
Creators: name: Moisander, Mikko
name: Skyttä, Tanja
name: Kivistö, Sari
name: Huhtala, Heini
name: Nikus, Kjell
name: Virtanen, Vesa
name: Kellokumpu-Lehtinen, Pirkko-Liisa
name: Raatikainen, Pekka
name: Tuohinen, Suvi
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Space Science
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 2: Figure S2. Fragmented QRS analysis example.
(400077) Alexander Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 3 of Radiotherapy-induced diffuse myocardial fibrosis in early-stage breast cancer patients – multimodality imaging study with six-year follow-up
Creators: name: Moisander, Mikko
name: Skyttä, Tanja
name: Kivistö, Sari
name: Huhtala, Heini
name: Nikus, Kjell
name: Virtanen, Vesa
name: Kellokumpu-Lehtinen, Pirkko-Liisa
name: Raatikainen, Pekka
name: Tuohinen, Suvi
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Space Science
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 3: Figure S3. T1, T2 and extracellular volume (ECV) mapping in the CMR imaging.
(400079) George Todd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Replication initiation and elongation fork rates within a differentially expressed human multicopy locus in early S phase
Creators: name: Truong, K. Young
name: Scott, Rona S.
name: Vos, Jean Michel H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Replication of the 400 copies of the 43 kb human ribosomal RNA (rDNA) locus spans most of the S phase. To examine the basis for the unusual pattern of rDNA replication, a sensitive strategy was developed to map origins of DNA replication and measure apparent rates of fork progression within a chromosomal locus. This technique, termed differential intragenomic replication timing, revealed that initiation within the actively transcribed rDNA occurred in early S within a 10.7 kb region spanning the promoter and 5' external transcribed spacer. Forks emanating from this early bidirectional origin progressed at an apparent slow rate with the sense and anti-sense forks moving at 0.32 and 0.23 kb/min. Using a photochemical-based technique, the chromatin status of the rDNA repeats was assayed throughout the S phase. Approximately 85% of the rDNA repeats were in a transcriptionally active chromatin structure at the start of S phase. A progressive decrease in the transcription state of the rDNA loci was observed, reaching a minimum between 3 and 6 h in mid S phase. Altogether, the data suggest a link between RNA polymerase I mediated transcription and site-specific initiation of DNA replication within the rDNA multicopy locus.
Partially twisted superconformal M5 brane in R-symmetry gauge field backgrounds
Creators: name: Bak, Dongsu
name: Gustavsson, Andreas
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We obtain the action for a curved superconformal abelian M5 brane with the background R-symmetry gauge field turned on. We then restrict ourselves to superconformal M5 brane on a sphere times flat Minkowski space. We choose R-symmetry SO(1,4) instead of SO(5), which enables us to partially twist on Minkowski space and replace it by some curved Lorentzian manifold. We obtain M5 brane actions on $M_{1,1} \times S^4$ and $M_{1,2} \times S^3$ where actions and all fields, including the background gauge field, are real. Dimensional reduction along time gives real 5d SYM actions with nonabelian generalizations.
description: 31 pages, a discussion on unitarity is added
Rodent UV-Sensitive Mutant Cell Lines in Complementation Groups 6-10 Have Normal General Excision Repair Activity
Creators: name: Thompson, Larry H.
name: Reardon, Joyce T.
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Mammalian nucleotide excision repair is the primary enzymatic pathway for removing bulky lesions from DNA. The repair reaction involves three main steps: (i) dual incisions on both sides of the lesion; (ii) excision of the damaged base in an oligonucleotide 24-31 nt in length; (iii) filling in of the post-excision gap and ligation. We have developed assays that probe the individual steps of the reaction. Using these methods (assays for incision, excision and repair patch synthesis), we demonstrate that the mammalian excision nuclease system removes bulky lesions by incising mainly at the 22nd-25th phosphodiester bonds 5'and the 3rd-5th phosphodiester bonds 3'of the lesion, thus releasing oligonucleotides primarily 26-29 nt in length. The resulting excision gap is filled in by DNA polymerases delta and epsilon as revealed by the 'phosphorothioate repair patch assay'. When these assays were employed with cell-free extracts from the moderately UV-sensitive rodent mutants in complementation groups 6-10, we found that these mutants are essentially normal in all three steps of the repair reaction. This leads us to conclude that these cell lines have normal in vitro repair activities and that the defects in these mutants are most likely in genes controlling cellular functions not directly involved in general excision repair.
Implications and applications of the variance-based uncertainty equalities
Creators: name: Yao, Yao
name: Xiao, Xing
name: Wang, Xiaoguang
name: Sun, C. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In quantum mechanics, the variance-based Heisenberg-type uncertainty relations are a series of mathematical inequalities posing the fundamental limits on the achievable accuracy of the state preparations. In contrast, we construct and formulate two quantum uncertainty equalities, which hold for all pairs of incompatible observables and indicate the new uncertainty relations recently introduced by L. Maccone and A. K. Pati [Phys. Rev. Lett. 113, 260401 (2014)]. Furthermore, we present an explicit interpretation lying behind the derivations and relate these relations to the so-called intelligent states. As an illustration, we investigate the properties of these uncertainty inequalities in the qubit system and a state-independent bound is obtained for the sum of variances. Finally, we apply these inequalities to the spin squeezing scenario and its implication in interferometric sensitivity is also discussed.
description: 9 pages, 4 figures. Any comments will be appreciated
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
Creators: name: Li, Guo Min
name: Hong, Yu
name: McCulloch, Scott
name: Watanabe, Hiroyuki
name: Gu, Liya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: DNA mismatch repair ensures genomic stability by correcting biosynthetic errors and by blocking homologous recombination. MutS-like and MutL-like proteins play important roles in these processes. In Escherichia coli and yeast these two types of proteins form a repair initiation complex that binds to mismatched DNA. However, whether human MutS and MutL homologs interact to form a complex has not been elucidated. Using immunoprecipitation and Western blot analysis we show here that human MSH2, MLH1, PMS2 and proliferating cell nuclear antigen (PCNA) can be co-immunoprecipitated, suggesting formation of a repair initiation complex among these proteins. Formation of the initiation complex is dependent on ATP hydrolysis and at least functional MSH2 and MLH1 proteins, because the complex could not be detected in tumor cells that produce truncated MLH1 or MSH2 protein. We also demonstrate that PCNA is required in human mismatch repair not only at the step of repair initiation, but also at the step of repair DNA re-synthesis.