title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÐ»ÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐ²ÑÐ·ÑÐ²Ð°Ð½Ð¸Ñ Ð´Ð¸Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² Ñ Ð³Ð»Ð¾Ð±ÑÐ»ÑÑÐ½ÑÐ¼Ð¸ Ð±ÐµÐ»ÐºÐ°Ð¼Ð¸ Ð¸ Ð´Ð½ÐÐÐ
title: Ð½Ð°ÑÑÐ½ÑÐ¹ Ð´Ð¾ÐºÐ»Ð°Ð´
titleType: Subtitle
title: Systematic search for structural motifs of dipeptide binding to double-stranded DNA and globular proteins
Creators: name: ÐÐ¾Ð»ÑÐ¸Ð½Ð°, ÐÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÐÐµÐ¿ÑÐ¸Ð´Ñ
Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ðµ Ð¿ÐµÐ¿ÑÐ¸Ð´Ñ
ÐÐÐ
molecular modeling
short peptides
DNA

description: Ð¡ÑÑÐµÑÑÐ²ÑÐµÑ Ð±Ð¾Ð»ÑÑÐ¾Ðµ ÑÐ°Ð·Ð½Ð¾Ð¾Ð±ÑÐ°Ð·Ð¸Ðµ ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸ Ð°ÐºÑÐ¸Ð²Ð½ÑÑ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð², ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½Ð¾Ð¹, Ð°Ð½ÑÐ¸Ð±Ð°ÐºÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹, Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²Ð¾Ð¹, Ð°Ð½ÑÐ¸Ð²Ð¾Ð·ÑÐ°ÑÑÐ½Ð¾Ð¹ Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ, ÑÑÐ°ÑÑÐ²ÑÑÑ Ð² ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ ÑÑÐ½ÐºÑÐ¸Ð¹ Ð½ÐµÐ¹ÑÐ¾-Ð¸Ð¼Ð¼ÑÐ½Ð¾ÑÐ½Ð´Ð¾ÐºÑÐ¸Ð½Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ, Ð°Ð¿Ð¾Ð¿ÑÐ¾Ð·Ð°, Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ð¸ Ð¸ Ð´Ð¸ÑÑÐµÑÐµÐ½ÑÐ¸ÑÐ¾Ð²ÐºÐµ ÐºÐ»ÐµÑÐ¾Ðº. ÐÐ¾ÑÑÐ¾Ð¼Ñ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ñ Ð¸Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¸Ð²Ð»ÐµÐºÐ°ÑÑ Ð²ÑÐµ Ð±Ð¾Ð»ÑÑÐµÐµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ Ð½Ðµ ÑÐ¾Ð»ÑÐºÐ¾ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð¹ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸, Ð±Ð¸Ð¾Ñ Ð¸Ð¼Ð¸Ð¸ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð·Ð¸ÐºÐµ, Ð½Ð¾ ÑÐ°ÐºÐ¶Ðµ Ð² ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ðµ. Ð ÑÑÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¼Ñ ÑÐ¸ÑÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð»Ð¸ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ Ð´Ð¸Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² (Ð²ÑÐµÑ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÑ ÐºÐ¾Ð¼Ð±Ð¸Ð½Ð°ÑÐ¸Ð¹ Ð¸Ð· 20 ÑÑÐ°Ð½Ð´Ð°ÑÑÐ½ÑÑ Ð°Ð¼Ð¸Ð½Ð¾ÐºÐ¸ÑÐ»Ð¾Ñ) ÑÐ²ÑÐ·ÑÐ²Ð°ÑÑÑÑ ÑÐ¾ Ð²ÑÐµÐ¼Ð¸ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÐ¼Ð¸ ÐºÐ¾Ð¼Ð±Ð¸Ð½Ð°ÑÐ¸ÑÐ¼Ð¸ ÑÐµÑÑÐ°-Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¸Ð´Ð¾Ð² Ð² ÑÐµÐ½ÑÑÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ°ÑÑÐ¸ Ð´Ð½ÐÐÐ Ð² ÐºÐ»Ð°ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ B-ÑÐ¾ÑÐ¼Ðµ Ð¸ Ð³Ð»Ð¾Ð±ÑÐ»ÑÑÐ½ÑÐ¼Ð¸ Ð±ÐµÐ»ÐºÐ°Ð¼Ð¸ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð³Ð¾ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ. Ð­ÑÐ¸ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð²Ð¿ÐµÑÐ²ÑÐµ Ð¿ÑÐ¾Ð»Ð¸Ð²Ð°ÑÑ ÑÐ²ÐµÑ Ð½Ð° Ð¾Ð±ÑÑÑ ÐºÐ°ÑÑÐ¸Ð½Ñ ÑÐ²ÑÐ·ÑÐ²Ð°Ð½Ð¸Ñ ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ñ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð¾Ð² Ñ Ð´Ð½ÐÐÐ Ð¸ Ð³Ð»Ð¾Ð±ÑÐ»ÑÑÐ½ÑÐ¼Ð¸ Ð±ÐµÐ»ÐºÐ°Ð¼Ð¸.
description: A large variety of short biologically active peptides possesses antioxidant, antibacterial, antitumor, anti-ageing and anti-inflammatory activity, involved in the regulation of neuro-immuno-endocrine system functions, cell apoptosis, proliferation and differentiation. Therefore, the mechanisms of their biological activity are attracting increasing attention not only in modern molecular biology, biochemistry and biophysics, but also in pharmacology and medicine. In this work, we systematically analyzed the ability of dipeptides (all possible combinations of the 20 standard amino acids) to bind with all possible combinations of tetra-nucleotides in the central part of dsDNA in the classic B-form and globular proteins using molecular docking and molecular dynamics. These results for the first time shed light onto general pattern of DNA and proteins binding with short peptides.