cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Sorting biotic and abiotic stresses on wild rocket by leaf-image hyperspectral data mining with an artificial intelligence model
Creators: name: Navarro, Alejandra
name: Nicastro, Nicola
name: Costa, Corrado
name: Pentangelo, Alfonso
name: Cardarelli, Mariateresa
name: Ortenzi, Luciano
name: Pallottino, Federico
name: Cardi, Teodoro
name: Pane, Catello
Publisher: name: figshare
Year: 2022
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Table S1. Indeces used for comparison of treatments in this work. Table S2. Effects of the abiotic and biotic stress on the vegetation indeces at the end of the experimental period.
A cross-sectional examination of the early-onset hypertensive disorders of pregnancy and industrial emissions of toxic metals using Kentucky birth records, 2008–2017
Creators: name: Kucharska-Newton, A
name: Walker, C.J
name: Browning, S.R
name: Christian, W.J
Publisher: name: Public Library of Science
Year: 2022

description: This cross-sectional study assessed geospatial patterns of early-onset hypertensive disorders of pregnancy (eHDP) in primiparous mothers and exposure to industrial emissions using geocoded residential information from Kentucky live (N = 210,804) and still (N = 1,247) birth records (2008–2017) and census block group estimates of aerosol concentrations of arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), selenium (Se), and zinc (Zi) from the Risk Screening Environmental Indicators (RSEI) model. A latent class analysis allowed for the identification of four district exposure classes—As, Cd, and Pb (12.6%); Se and Zi (21.4%); Pb and Cr (8%); and low or no exposures (57.9%). Women classified as having a high probability of exposure to both Pb and Cr had a statistically significantly greater prevalence of eHDP after adjusting for demographic factors (aPR = 1.22, 95% CI: 1.04, 1.44) relative to those with low or no exposure. Our findings contribute to the emerging literature on the association of metal exposures with pregnancy outcomes.
The Dhangar Dynasties Of The Deccan
Creators: name: RODRIGUES, TENSING CARLOS
Publisher: name: figshare
Year: 2017
Subjects: subject: History
subject: Anthropology
subject: FOS: Sociology
subject: Archaeology
subject: Geography
subject: Sociology

description: But a stronger proof of the dhangar origin of the Vijayānagara kings come from the gods they worshipped. Hampi has two majestic temples, one for Virūpākṣa and the other for Viṭhṭhala. Virūpākṣa is none other than Bīrāppa, from the pastoralists’ paired gods Viṭhṭhala-Bīrāppa. Though the Saṅgama brothers claimed descent from Yādu, and Hakka changed his name to Harihara (Hari = Shiva + Hara = Vishnu), they did not abandon their ancestral gods; they simply raised them to the Vedic pantheon : Bīrāppa as Shiva (Virūpākṣa) and Viṭhṭhala as Vishnu (Kṛṣṇa). But they could not do without reminding themselves and the world of their origins : the Viṭhṭhala temple at Hampi has bas-reliefs of dhangar – the only human images among the divine; the dhangar in these images stands with blanket draped over his head, arms resting on a staff and the chin resting on the arm.
Additional file 1 of Neck-specific strengthening exercise compared with placebo sham ultrasound in patients with migraine: a randomized controlled trial
Creators: name: Benatto, Mariana Tedeschi
name: Florencio, Lidiane Lima
name: Bragatto, Marcela Mendes
name: Dach, Fabíola
name: Fernández-de-las-Peñas, César
name: Bevilaqua-Grossi, Débora
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Guidelinebook for sham ultrasound group.
Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The ARIC Study
Creators: name: Matsushita, K
name: Schrack, J.A
name: Lutsey, P.L
name: Mok, Y
name: Salameh, M
name: Coresh, J
name: Palta, P
name: Kucharska-Newton, A.M
name: Windham, B.G
name: Ishigami, J
name: Sang, Y
name: Folsom, A.R
Publisher: name: NLM (Medline)
Year: 2022

description: BACKGROUND: Although a few studies reported an association between varicose veins and physical function, this potentially bidirectional association has not been systematically evaluated in the general population. METHOD: In 5 580 participants (aged 71-90 years) from the Atherosclerosis Risk in Communities study, varicose veins were identified in outpatient and inpatient administrative data prior to (prevalent cases) and after (incident cases) visit 5 (2011-2013). Physical function was evaluated by the Short Physical Performance Battery (SPPB, score ranging from 0 to 12). We evaluated (i) cross-sectional association between prevalent varicose veins and physical function, (ii) association of prevalent varicose veins with subsequent changes in physical function from visit 5 to visits 6 (2016-2017) and 7 (2018-2019), and (iii) association of physical function at visit 5 with incident varicose veins during a median follow-up of 3.6 years (105 incident varicose veins among 5 350 participants without prevalent cases at baseline). RESULTS: At baseline, varicose veins were recognized in 230 (4.1%) participants and cross-sectionally associated with reduced physical function. Longitudinally, prevalent varicose veins were not significantly associated with a decline in SPPB over time. In contrast, a low SPPB ≤6 was associated with a greater incidence of varicose veins compared to SPPB ≥10 (adjusted hazard ratio 2.13 [95% confidence interval = 1.19, 3.81]). CONCLUSION: In community-dwelling older adults, varicose veins and low physical function were associated cross-sectionally. Longitudinally, low physical function was a risk factor for incident varicose veins, but not vice versa. Our findings suggest an etiological contribution of low physical function to incident varicose veins.
Additional file 2 of Neck-specific strengthening exercise compared with placebo sham ultrasound in patients with migraine: a randomized controlled trial
Creators: name: Benatto, Mariana Tedeschi
name: Florencio, Lidiane Lima
name: Bragatto, Marcela Mendes
name: Dach, Fabíola
name: Fernández-de-las-Peñas, César
name: Bevilaqua-Grossi, Débora
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2. Clinical relevance of primary outcomes.
Additional file 3 of Neck-specific strengthening exercise compared with placebo sham ultrasound in patients with migraine: a randomized controlled trial
Creators: name: Benatto, Mariana Tedeschi
name: Florencio, Lidiane Lima
name: Bragatto, Marcela Mendes
name: Dach, Fabíola
name: Fernández-de-las-Peñas, César
name: Bevilaqua-Grossi, Débora
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3. Clinical relevance of secondary outcomes.
Psychosocial factors and subsequent risk of hospitalizations with peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: Honda, Y
name: Mok, Y
name: Hof, J.R.V
name: Coresh, J
name: Mosley, T
name: Matsushita, K
name: Mathews, L
name: Kucharska-Newton, A
name: Selvin, E
name: Daumit, G
Publisher: name: Elsevier Ireland Ltd
Year: 2021

description: Background and aims: Psychosocial factors are associated with increased risk of cardiovascular disease (CVD). However, associations with peripheral artery disease (PAD) remain uncharacterized. We aimed to compare associations of psychosocial factors with the risk of PAD and two other major atherosclerotic CVD: coronary heart disease (CHD) and ischemic stroke, in the Atherosclerosis Risk in Communities (ARIC) Study. Methods: In 11,104 participants (mean age 56.7 [SD 5.7] years) without a clinical history of PAD and CHD/stroke at baseline (1990–1992), we evaluated four psychosocial domains: depressive/fatigue symptoms by the Maastricht Questionnaire, social support by the Interpersonal Evaluation List, social networks by the Lubben Scale, and trait anger by the Spielberger Scale. PAD was defined as hospitalizations with diagnosis or related procedures. CHD included adjudicated coronary heart disease and stroke included ischemic stroke. Results: We observed 397 PAD and 1940 CHD/stroke events during a median follow-up of 23.1 years. Higher depressive/fatigue symptoms and less social support were significantly associated with incident PAD (adjusted hazard ratios for top vs. bottom quartile 1.65 [95%CI, 1.25–2.19] and 1.40 [1.05–1.87], respectively). When these factors were simultaneously modeled, only depressive/fatigue symptoms remained significant. Incident CHD/stroke was not associated with either of depressive/fatigue symptoms or social support. Social networks and trait anger were not independently associated with PAD or CHD/stroke. Conclusions: Depressive/fatigue symptoms and social support (especially the former) were independently associated with the risk of hospitalizations with PAD but not CHD/stroke in the general population. Our results support the importance of depressive/fatigue symptoms in vascular health and suggest the need of including PAD when studying the impact of psychosocial factors on CVD.
EinsteinPy Proposal for Enhancement 1: EPEs and EinsteinPy Governance (EPE1)
Creators: name: Bapat, Shreyas
Publisher: name: Zenodo
Year: 2020

description: EPE stands for EinsteinPy Proposal for Enhancement. An EPE is actually a design document providing important information, details and governance models to the EinsteinPy community, or describing a new feature for EinsteinPy or its affiliated packages. The EPE should provide a concise technical specification of the feature and a rationale for the feature. If the EPE is intended to be regarding a governance specific model, a member meeting should be organized and the EPE must get at least 51% votes to pass. We intend EPEs to be the primary mechanisms for proposing major new features, for collecting community input on an issue, and for documenting the design decisions that have gone into Python. The EPE author is responsible for building consensus within the community and documenting dissenting opinions. The EPE author is obligated to write a formal email to all@einsteinpy.org for a community meeting. Because the EPEs are maintained as text files in a versioned repository (indirectly since this wiki is versioned within GitHub), their revision history is the historical record of the feature proposal The EPE is the beginning of formalism in the future major changes in EinsteinPy. This EPE is meant for understanding what EinsteinPy Enhancement Proposals are, what function they serve, and how they can be implemented.
Hospital to Home Transition for Patients With Stroke Under Bundled Payments
Creators: name: Kucharska-Newton, A.M
name: Halladay, J.R
name: Trogdon, J.G
name: Duncan, P.W
name: Hou, Y
name: Bushnell, C.D
name: Freburger, J.K
Publisher: name: W.B. Saunders
Year: 2021

description: Bundled payments are a promising alternative payment model for reducing costs and improving the coordination of postacute stroke care, yet there is limited evidence supporting the effectiveness of bundled payments for stroke. This may be due to the lack of effective strategies to address the complex needs of stroke survivors. In this article, we describe COMprehensive Post-Acute Stroke Services (COMPASS), a comprehensive transitional care intervention focused on discharge from the acute care setting to home. COMPASS may serve as a potential care redesign strategy under bundled payments for stroke, such as the Centers for Medicare & Medicaid Innovation Bundled Payment for Care Improvement Initiative. The COMPASS care model is aligned with the incentive structures and essential components of bundled payments in terms of care coordination, patient assessment, patient and family involvement, and continuity of care. Ongoing evaluation will inform the design of incorporating COMPASS-like transitional care interventions into a stroke bundle.
Additional file 4 of Neck-specific strengthening exercise compared with placebo sham ultrasound in patients with migraine: a randomized controlled trial
Creators: name: Benatto, Mariana Tedeschi
name: Florencio, Lidiane Lima
name: Bragatto, Marcela Mendes
name: Dach, Fabíola
name: Fernández-de-las-Peñas, César
name: Bevilaqua-Grossi, Débora
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 4: (a) Representation of the mean of the normalized rootmean square (RMS) for the muscles anterior scalene and upper trapezius duringthe fourth (28 mmHg) and the fifth (30 mmHg) stage of the CCFT in the threeassessments for booth groups; *=p<0.05 for group-by-time interaction; (b) Representationof the mean of median frequency for muscles anterior scalene and spleniuscapitis during the flexor and extensor endurance test, in the two assessments, baselineand final, for booth groups; *=p
Spectral Form Factors of Topological Phases
Creators: name: Sarkar, Anurag
name: Pachhal, Subrata
name: Agarwala, Adhip
name: Das, Diptarka
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Signatures of dynamical quantum phase transitions and chaos can be found in the time evolution of generalized partition functions such as spectral form factors (SFF) and Loschmidt echoes. While a lot of work has focused on the nature of such systems in a variety of strongly interacting quantum theories, in this work, we study their behavior in short-range entangled topological phases, particularly focusing on the role of symmetry-protected topological zero modes. We show, using both analytical and numerical methods, how the existence of such zero modes in any representative system can mask the SFF with large period (akin to generalized Rabi) oscillations, hiding any behavior arising from the bulk of the spectrum. Moreover, in a quenched disordered system, these zero modes fundamentally change the late-time universal behavior reflecting the chaotic signatures of the zero-energy manifold. Our study uncovers the rich physics underlying the interplay of chaotic signatures and topological characteristics in a quantum system.
description: Expanded and published version : 8+4 pages, 10 figures
Ascertaining Framingham heart failure phenotype from inpatient electronic health record data using natural language processing: A multicentre Atherosclerosis Risk in Communities (ARIC) validation study
Creators: name: Moore, C.R
name: Whitsel, E
name: Yadav, H
name: Jain, S
name: Kucharska-Newton, A.M
name: Rosamand, W
name: Haas, S
name: Heiss, G
Publisher: name: BMJ Publishing Group
Year: 2021

description: Objectives: Using free-text clinical notes and reports from hospitalised patients, determine the performance of natural language processing (NLP) ascertainment of Framingham heart failure (HF) criteria and phenotype. Study design: A retrospective observational study design of patients hospitalised in 2015 from four hospitals participating in the Atherosclerosis Risk in Communities (ARIC) study was used to determine NLP performance in the ascertainment of Framingham HF criteria and phenotype. Setting: Four ARIC study hospitals, each representing an ARIC study region in the USA. Participants A stratified random sample of hospitalisations identified using a broad range of International Classification of Disease, ninth revision, diagnostic codes indicative of an HF event and occurring during 2015 was drawn for this study. A randomly selected set of 394 hospitalisations was used as the derivation dataset and 406 hospitalisations was used as the validation dataset. Intervention Use of NLP on free-text clinical notes and reports to ascertain Framingham HF criteria and phenotype. Primary and secondary outcome measures NLP performance as measured by sensitivity, specificity, positive-predictive value (PPV) and agreement in ascertainment of Framingham HF criteria and phenotype. Manual medical record review by trained ARIC abstractors was used as the reference standard. Results Overall, performance of NLP ascertainment of Framingham HF phenotype in the validation dataset was good, with 78.8%, 81.7%, 84.4% and 80.0% for sensitivity, specificity, PPV and agreement, respectively. Conclusions: By decreasing the need for manual chart review, our results on the use of NLP to ascertain Framingham HF phenotype from free-text electronic health record data suggest that validated NLP technology holds the potential for significantly improving the feasibility and efficiency of conducting large-scale epidemiologic surveillance of HF prevalence and incidence.
Temporal Trends and Prognosis of Physical Examination Findings in Patients with Acute Decompensated Heart Failure: The ARIC Study Community Surveillance
Creators: name: Vaduganathan, M
name: Caughey, M.C
name: Kucharska-Newton, A
name: Kolupoti, A
name: Fudim, M
name: Pandey, A
name: Mentz, R.J
name: Hall, M.E
Publisher: name: Lippincott Williams and Wilkins
Year: 2021

description: BACKGROUND: Bedside evaluation of congestion is a mainstay of heart failure (HF) management. Whether detected physical examination signs have changed over time as obesity prevalence has increased in HF populations, or if the associated prognosis differs for HF with reduced or preserved ejection fraction (HFrEF or HFpEF) is uncertain. METHODS: From 2005 to 2014, the ARIC study (Atherosclerosis Risk in Communities) conducted adjudicated hospital surveillance of acute decompensated HF. We analyzed trends in physical examination findings, imaging signs, and symptoms related to congestion, both over time and by obesity class, and associated 28-day mortality risks. RESULTS: Of 24 937 weighted hospitalizations for acute decompensated HF (mean age 75 years, 53% women, 32% Black), 47% had HFpEF. The prevalence of obesity increased from 2005 to 2014 for both HF types. With increasing obesity category, detected edema increased, while jugular venous distension decreased, and rales remained stable. Detected edema also increased over time, for both HF types. Associations between 28-day mortality and individual signs and symptoms of congestion were similar for HFpEF and HFrEF; however, the adjusted mortality risk with all 3 (edema, rales, and jugular venous distension) versus <3 physical examination findings was higher for patients with HFpEF (odds ratio, 2.41 [95% CI, 1.53-3.79]) than HFrEF (odds ratio, 1.30 [95% CI, 0.87-1.93]); P for interaction by HF type =0.02. CONCLUSIONS: In patients hospitalized with acute decompensated HF, detected physical examination findings differ both temporally and by obesity. Combined findings from the physical examination are more prognostic of 28-day mortality for patients with HFpEF than HFrEF.
Disparities by sex in P2Y 12 inhibitor therapy duration, or differences in the balance of ischaemic-benefit and bleeding-risk clinical outcomes in older women versus comparable men following acute myocardial infarction? A P2Y 12 inhibitor new user retrospective cohort analysis of US Medicare claims data
Creators: name: Hickson, R.P
name: Kucharska-Newton, A.M
name: Fang, G
name: Rodgers, J.E
name: Sleath, B.L
Publisher: name: BMJ Publishing Group
Year: 2021

description: Objectives To determine if comparable older women and men received different durations of P2Y 12 inhibitor therapy following acute myocardial infarction (AMI) and if therapy duration differences were justified by differences in ischaemic benefits and/or bleeding risks. Design Retrospective cohort. Setting 20% sample of 2007-2015 US Medicare fee-for-service administrative claims data. Participants ≥66-year-old P2Y 12 inhibitor new users following 2008-2013 AMI hospitalisation (N=30 613). Older women compared to older men with similar predicted risks of study outcomes. Primary and secondary outcome measures Primary outcome: P2Y 12 inhibitor duration (modelled as risk of therapy discontinuation). Secondary outcomes: clinical events while on P2Y 12 inhibitor therapy, including (1) death/hospice admission, (2) composite of ischaemic events (AMI/stroke/revascularisation) and (3) hospitalised bleeds. Cause-specific risks and relative risks (RRs) estimated using Aalen-Johansen cumulative incidence curves and bootstrapped 95% CIs. Results 10 486 women matched to 10 486 men with comparable predicted risks of all 4 study outcomes. No difference in treatment discontinuation was observed at 12 months (women 31.2% risk; men 30.9% risk; RR 1.01; 95% CI 0.97 to 1.05), but women were more likely than men to discontinue therapy at 24 months (54.4% and 52.9% risk, respectively; RR 1.03; 95% CI 1.00 to 1.05). Among patients who did not discontinue P2Y 12 inhibitor therapy, women had lower 24-month risks of ischaemic outcomes than men (13.1% and 14.7%, respectively; RR 0.90; 95% CI 0.84 to 0.96), potentially lower 24-month risks of death/hospice admission (5.0% and 5.5%, respectively; RR 0.91; 95% CI 0.82 to 1.02), but women and men both had 2.5% 24-month bleeding risks (RR 0.98; 95% CI 0.82 to 1.14). Conclusions Risks for death/hospice and ischaemic events were lower among women still taking a P2Y 12 inhibitor than comparable men, with no difference in bleeding risks. Shorter P2Y 12 inhibitor durations in older women than comparable men observed between 12 and 24 months post-AMI may reflect a disparity that is not justified by differences in clinical need.
Additional file 1 of Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages
Creators: name: Kono-Sato, Takako
name: Miyai, Kosuke
name: Yamagishi, Yoji
name: Miyamoto, Morikazu
name: Takano, Masashi
name: Matsukuma, Susumu
name: Sato, Kimiya
name: Tsuda, Hitoshi
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 1. Supplementary Table 1. Quantitative TILs and TAMs and cut-off values (n = 107).
Subclinical Vascular Disease Burden and Premature Mortality Among Middle-aged Adults: the Atherosclerosis Risk in Communities Study
Creators: name: Wu, C
name: Windham, B.G
name: Gottesman, R.F
name: Kucharska-Newton, A.M
name: Palta, P
name: Zhang, K
name: Odden, M.C
name: Matsushita, K
Publisher: name: Springer
Year: 2021

description: Background: Whether high burden of subclinical vascular disease (SVD) is associated with increased premature mortality among middle-aged adults is not adequately understood. The association of midlife SVD burden with premature mortality among middle-aged adults free of clinical cardiovascular disease (CVD) could provide further insights into stratifying premature death beyond clinical CVD. Objective: To determine whether high burden of subclinical vascular disease is associated with increased premature mortality among middle-aged adults. Design: We leveraged data from the Atherosclerosis Risk in Communities Study. Participants: Thirteen thousand eight hundred seventy-six community-dwelling blacks and whites aged 45–64 years from the Atherosclerosis Risk in Communities Study. Main Measures: Each SVD measure—ankle-brachial index, carotid intima-media thickness, and electrocardiogram—was scored 0 (no abnormalities), 1 (minor abnormalities), or 2 (major abnormalities). An index was constructed as the sum of three measures, ranging from 0 (lowest burden) to 6 (highest burden). We used the Cox proportional-hazards model to determine the association of SVD burden with premature mortality (death before age 70) among persons free of clinical CVD. We then tested the difference in point estimates between SVD and clinical CVD. Key Results: Among persons without CVD, the premature death was 1.7, 2.1, 2.5, and 3.8 per 1000 person-years among those with an SVD score of 0 (lowest burden), 1, 2, and 3–6 (highest burden), respectively. After multivariable-adjustment, highest SVD burden (score = 3–6; HR = 1.47) was significantly associated with premature death among persons initially without CVD. In the model where persons with and without CVD were included, high SVD burden (score: 3–6 vs. 0) and CVD did not have hugely different association with premature death (HR = 1.49 vs. 1.68; P = 0.32 for comparison). Conclusions: Midlife SVD burden was associated with premature mortality and it could stratify premature death beyond clinical CVD. It is important to take SVD into account when designing interventions for reducing premature mortality.
Ordonnance du garde-scel de la chancellerie près le conseil souverain, qui défend aux Procureurs & à toutes personnes de s’immiscer en la confection des Lettres de Chancellerie, à peine de trois cent livres d'amende, & de plus grande peine s'il y échet
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
name: Six, Philippe-Josse-Auguste-Joseph (1732-1793)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: Officier de justice d'Ancien Régime
Justice royale
Organisation judiciaire

description: Source: http://nordnum.univ-lille.fr/ark:/72505/a0115224001360im5Ol/from/a011522400136ypxWl2
description: Coverage: Parlement de Flandre
description: created: 02/10/2018
description: created: 02/07/1683
Additional file 1 of Differential richness inference for 16S rRNA marker gene surveys
Creators: name: Kumar, M. Senthil
name: Slud, Eric V.
name: Hehnly, Christine
name: Zhang, Lijun
name: Broach, James
name: Irizarry, Rafael A.
name: Schiff, Steven J.
name: Paulson, Joseph N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Presents the theoretic models for substitution errors introduced during amplification and sequencing, incorporating back mutations. The influence of recovered abundance-dependent accumulation of false sequencing read classifications is characterized. Related figures and literature references are contained within the note.
The aortic-femoral arterial stiffness gradient is blood pressure independent in older adults: the atherosclerosis risk in communities (ARIC) study
Creators: name: Hughes, T.M
name: Paterson, C
name: Stoner, L
name: Faulkner, J
name: Matsushita, K
name: Tanaka, H
name: Kucharska-Newton, A
name: Heffernan, K
name: Stone, K
name: Zieff, G
name: Meyer, M.L
name: Fryer, S
Publisher: name: Lippincott Williams and Wilkins
Year: 2021

description: Background:Aortic arterial stiffness is a strong independent predictor of cardiovascular disease (CVD); however, its dependence on mean arterial pressure (MAP) limits its clinical utility. The aortic-femoral arterial stiffness gradient (af-SG), a novel marker of CVD risk, may be a promising alternative, but its dependence on MAP is not known. The aim of this study was to determine the relationship between MAP and the af-SG in healthy older adults and those with established disease, including hypertension and diabetes.Method:We evaluated the dependency of the af-SG on MAP in healthy older adults (n = 694, aged 74 ± 5 years), and adults with hypertension (n = 2040, aged 76 ± 5 years), and diabetes (n = 1405, aged 75 ± 5 years) as part of the community-based Atherosclerosis Risk in Communities (ARIC) Study. Carotid-femoral pulse-wave velocity (cfPWV), femoral-ankle PWV (faPWV) and blood pressure were measured using standardized protocols. The af-SG was calculated as faPWV divided by cfPWV. Multivariable regression analysis was performed to test the independent association of MAP with af-SG, with adjustments for known confounders, including age, sex, BMI, blood glucose and heart rate.Results:There was no significant relationship between the af-SG and MAP in healthy (β = 0.002, P = 0.301), hypertension (β = -0.001, P = 0.298) or diabetes (β = -0.001, P = 0.063) population groups, with MAP explaining less than 0.1, less than 0.1 and 0.2% of the variance in the af-SG, respectively.Conclusion:These findings suggest that the af-SG may be regarded as a MAP independent index of arterial health and CVD risk in older adults.
The aortic-femoral arterial stiffness gradient: An atherosclerosis risk in communities (ARIC) study
Creators: name: Kucharska-Newton, A
name: Hughes, T.M
name: Paterson, C
name: Zieff, G
name: Fryer, S
name: Stone, K
name: Tanaka, H
name: Meyer, M.L
name: Faulkner, J
name: Stoner, L
name: Matsushita, K
name: Credeur, D
Publisher: name: Lippincott Williams and Wilkins
Year: 2021

description: Background:The aortic to femoral arterial stiffness gradient (af-SG) may be a novel measure of arterial health and cardiovascular disease (CVD) risk, but its association with CVD risk factors and CVD status, and whether or not they differ from the referent measure, carotid-femoral pulse-wave velocity (cfPWV), is not known.Method:Accordingly, we compared the associations of the af-SG and cfPWV with (i) age and traditional CVD risk factors and (ii) CVD status. We evaluated 4183 older-aged (75.2 ± 5.0 years) men and women in the community-based Atherosclerosis Risk in Communities (ARIC) Study. cfPWV and femoral-ankle PWV (faPWV) were measured using an automated cardiovascular screening device. The af-SG was calculated as faPWV divided by cfPWV. Associations of af-SG and cfPWV with age, CVD risk factors (age, BMI, blood pressure, heart rate, glucose and blood lipid levels) and CVD status (hypertension, diabetes, coronary heart disease, heart failure, stroke) were determined using linear and logistic regression analyses.Results:(i) the af-SG and cfPWV demonstrated comparable associations with age and CVD risk factors, except BMI. (ii) a low af-SG was associated with diabetes, coronary heart disease, heart failure and stroke, whilst a high cfPWV was only associated with diabetes.Conclusion:Although future studies are necessary to confirm clinical utility, the af-SG is a promising tool that may provide a unique picture of hemodynamic integration and identification of CVD risk when compared with cfPWV.
Albuminuria and Prognosis Among Individuals With Atherosclerotic Cardiovascular Disease: The ARIC Study
Creators: name: Stacey, R.B.
name: Chang, P.P.
name: Koton, S.
name: Rosamond, W.
name: Kucharska-Newton, A.
name: Coresh, J.
name: Matsushita, K.
name: Ballew, S.H.
name: Rossi, J.
name: Mok, Y.
Publisher: name: Elsevier Inc.
Year: 2021

description: The American College of Cardiology and the American Heart Association 2018 Cholesterol Guideline proposed the new classification of “very high-risk” atherosclerotic cardiovascular disease (ASCVD) (multiple ASCVDs or 1 ASCVD plus $2 high-risk conditions) to guide intensive secondary prevention. This guideline takes into account reduced glomerular filtration rate (GFR) as a high-risk condition, but not albuminuria, a measure of kidney damage, that is more strongly associated with cardiovascular outcomes than reduced GFR. Importantly, the assessment of albuminuria is already recommended in patients with diabetes and hypertension, and thus, data of albuminuria are readily available in many patients with ASCVD. We explored whether urine albumin-to-creatinine ratio (ACR) is independently associated with adverse outcomes and can improve risk prediction in persons with ASCVD beyond the high-risk conditions in the guideline.
Additional file 3 of Differential richness inference for 16S rRNA marker gene surveys
Creators: name: Kumar, M. Senthil
name: Slud, Eric V.
name: Hehnly, Christine
name: Zhang, Lijun
name: Broach, James
name: Irizarry, Rafael A.
name: Schiff, Steven J.
name: Paulson, Joseph N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Presents supplementary tables S1-S3. Related literature references are contained within the note.
Hospital readmissions and mortality among fee-for-service medicare patients with minor stroke or transient ischemic attack: Findings from the COMPASS cluster-randomized pragmatic trial
Creators: name: Jones, S.B
name: Johnson, A.M
name: Daras, L.C
name: Psioda, M.A
name: Freburger, J.K
name: Coleman, S.W
name: Rosamond, W.D
name: Bushnell, C.D
name: Gesell, S.B
name: Sissine, M.E
name: Kucharska-Newton, A.M
name: Halladay, J.R
name: Duncan, P.W
name: Hunt, G.P
name: Wen, F
name: Bettger, J.P
Publisher: name: American Heart Association Inc.
Year: 2021

description: Background Mortality and hospital readmission rates may reflect the quality of acute and postacute stroke care. Our aim was to investigate if, compared with usual care (UC), the COMPASS-TC (Comprehensive Post-Acute Stroke Services Transitional Care) intervention (INV) resulted in lower all-cause and stroke-specific readmissions and mortality among patients with minor stroke and transient ischemic attack discharged from 40 diverse North Carolina hospitals from 2016 to 2018. Methods and Results Using Medicare fee-for-service claims linked with COMPASS cluster-randomized trial data, we performed intention-to-treat analyses for 30-day, 90-day, and 1-year unplanned all-cause and stroke-specific readmissions and all-cause mortality between INV and UC groups, with 90-day unplanned all-cause readmissions as the primary outcome. Effect estimates were determined via mixed logistic or Cox proportional hazards regression models adjusted for age, sex, race, stroke severity, stroke diagnosis, and documented history of stroke. The final analysis cohort included 1069 INV and 1193 UC patients (median age 74 years, 80% White, 52% women, 40% with transient ischemic attack) with median length of hospital stay of 2 days. The risk of unplanned all-cause readmission was similar between INV versus UC at 30 (9.9% versus 8.7%) and 90 days (19.9% versus 18.9%), respectively. No significant differences between randomization groups were seen in 1-year all-cause readmissions, stroke-specific readmissions, or mortality. Conclusions In this pragmatic trial of patients with complex minor stroke/transient ischemic attack, there was no difference in the risk of readmission or mortality with COMPASS-TC relative to UC. Our study could not conclusively determine the reason for the lack of effectiveness of the INV.
Depressive symptoms, cardiac structure and function, and risk of incident heart failure with preserved ejection fraction and heart failure with reduced ejection fraction in late life
Creators: name: Shah, A.M
name: Vu, K
name: Williams, J.E
name: Solomon, S.D
name: John, J.E
name: Claggett, B.L
name: Biering-Sørensen, T
name: Kucharska-Newton, A
name: Mosley, T.H
name: Skali, H
Publisher: name: American Heart Association Inc.
Year: 2021

description: BACKGROUND: Depressive symptoms are associated with heightened risk of heart failure (HF), but their association with cardiac function and with HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) in late life is un-clear. We aimed to determine the prevalence of depression in HFpEF and in HFrEF in late life, and the association of depressive symptoms with cardiac function and incident HFpEF and HFrEF. METHODS AND RESULTS: We studied 6025 participants (age, 75.3±5.1 years; 59% women; 20% Black race) in the ARIC (Atherosclerosis Risk in Communities) study at visit 5 who underwent echocardiography and completed the Center for Epidemiologic Studies Depression Scale questionnaire. Among HF-free participants (n=5086), associations of Center for Epidemiologic Studies Depression Scale score with echocardiography and incident adjudicated HFpEF and HFrEF were assessed using multivariable linear and Cox proportional hazards regression. Prevalent HFpEF, but not HFrEF, was associated with a higher prevalence of depression compared with HF-free participants (P<0.001 and P=0.59, respectively). Among HF-free participants, Center for Epidemiologic Studies Depression Scale score was not associated with cardiac structure and function after adjusting for demographics and comorbidities (all P>0.05). Over 5.5-year follow-up, higher Center for Epidemiologic Studies Depression Scale score was associated with heightened risk of incident HFpEF (hazard ratio [HR] [95% CI], 1.06 [1.04–1.12]; P=0.02), but not HFrEF (HR [95% CI], 1.02 [0.96–1.08]; P=0.54), independent of echocardiographic measures, NT-proBNP (N-terminal pro-B-type natriuretic peptide), troponin, and hs-CRP (high-sensitivity C-reactive protein) (HR [95% CI], 1.06 [1.00–1.12]; P=0.04). CONCLUSIONS: Worse depressive symptoms predict incident HFpEF in late life, independent of common comorbidities, cardiac structure and function, and prognostic biomarkers. Further studies are necessary to understand the mechanisms linking depression to risk of HFpEF.
title: ADCO, Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Cart. 143 (7 H 7), 153 fol, f. 0151r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0151r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0151r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb137389344
description: Provenance: abbaye de Molesme
description: Provenance: http://www.wikidata.org/entity/Q334044
Neural Hilbert Ladders: Multi-Layer Neural Networks in Function Space
Creators: name: Chen, Zhengdao
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Functional Analysis (math.FA)
subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: To characterize the function space explored by neural networks (NNs) is an important aspect of learning theory. In this work, noticing that a multi-layer NN generates implicitly a hierarchy of reproducing kernel Hilbert spaces (RKHSs) - named a neural Hilbert ladder (NHL) - we define the function space as an infinite union of RKHSs, which generalizes the existing Barron space theory of two-layer NNs. We then establish several theoretical properties of the new space. First, we prove a correspondence between functions expressed by L-layer NNs and those belonging to L-level NHLs. Second, we prove generalization guarantees for learning an NHL with a controlled complexity measure. Third, we derive a non-Markovian dynamics of random fields that governs the evolution of the NHL which is induced by the training of multi-layer NNs in an infinite-width mean-field limit. Fourth, we show examples of depth separation in NHLs under the ReLU activation function. Finally, we perform numerical experiments to illustrate the feature learning aspect of NN training through the lens of NHLs.
description: 65 pages, 3 figures. Published by the Journal of Machine Learning Research and presented partially at the 40th International Conference on Machine Learning (ICML 2023)
Additional file 2 of Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages
Creators: name: Kono-Sato, Takako
name: Miyai, Kosuke
name: Yamagishi, Yoji
name: Miyamoto, Morikazu
name: Takano, Masashi
name: Matsukuma, Susumu
name: Sato, Kimiya
name: Tsuda, Hitoshi
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 2. Supplementary Fig. 1. Recurrence-free survival curves of 60 stage IB endometrioid-type endometrial carcinoma. Curves were stratified by quantitative (A) CD3+ epithelial tumor-infiltrating lymphocytes (E-TILs), (B) CD8+ E-TILs, (C) CD3+ stromal TILs (S-TILs) and (D) CD8+ S-TILs. Curves were not significantly different.
Association of Nonacute opioid use and cardiovascular diseases: A scoping review of the literature
Creators: name: Kucharska-Newton, A.M
name: Singleton, J.H
name: Abner, E.L
name: Akpunonu, P.D
Publisher: name: American Heart Association Inc.
Year: 2021

description: BACKGROUND: In this scoping review, we identified and reviewed 23 original articles from the PubMed database that investigated the relationship between nonacute opioid use (NOU) and cardiovascular outcomes. METHODS AND RESULTS: We defined NOU to include both long-ŧerm opioid therapy and opioid use disorder. We summarized the association between NOU and 5 classes of cardiovascular disease, including infective endocarditis, coronary heart disease (including myocardial infarction), congestive heart failure, cardiac arrythmia (including cardiac arrest), and stroke. The most commonly studied outcomes were coronary heart disease and infective endocarditis. There was generally consistent evidence of a positive association between community prevalence of injection drug use (with opioids being the most commonly injected type of drug) and community prevalence of infective endocarditis, and between (primarily medically indicated) NOU and myocardial infarction. There was less consensus about the relationship between NOU and congestive heart failure, cardiac arrhythmia, and stroke. CONCLUSIONS: There is a dearth of high-quality evidence on the relationship between NOU and cardiovascular disease. Innovative approaches to the assessment of opioid exposure over extended periods of time will be required to address this need.
The Cost of Implementing and Sustaining the COMprehensive Post-Acute Stroke Services Model
Creators: name: Duncan, P.W
name: Kucharska-Newton, A.M
name: Trogdon, J.G
name: Bushnell, C.D
name: Bayliss, W.S
name: Halladay, J.R
name: Freburger, J.K
Publisher: name: Lippincott Williams and Wilkins
Year: 2021

description: Background:The COMprehensive Post-Acute Stroke Services (COMPASS) model, a transitional care intervention for stroke patients discharged home, was tested against status quo postacute stroke care in a cluster-randomized trial in 40 hospitals in North Carolina. This study examined the hospital-level costs associated with implementing and sustaining COMPASS.Methods:Using an activity-based costing survey, we estimated hospital-level resource costs spent on COMPASS-related activities during approximately 1 year. We identified hospitals that were actively engaged in COMPASS during the year before the survey and collected resource cost estimates from 22 hospitals. We used median wage data from the Bureau of Labor Statistics and COMPASS enrollment data to estimate the hospital-level costs per COMPASS enrollee.Results:Between November 2017 and March 2019, 1582 patients received the COMPASS intervention across the 22 hospitals included in this analysis. Average annual hospital-level COMPASS costs were $2861 per patient (25th percentile: $735; 75th percentile: $3,475). Having 10% higher stroke patient volume was associated with 5.1% lower COMPASS costs per patient (P=0.016). About half (N=10) of hospitals reported postacute clinic visits as their highest-cost activity, while a third (N=7) reported case ascertainment (ie, identifying eligible patients) as their highest-cost activity.Conclusions:We found that the costs of implementing COMPASS varied across hospitals. On average, hospitals with higher stroke volume and higher enrollment reported lower costs per patient. Based on average costs of COMPASS and readmissions for stroke patients, COMPASS could lower net costs if the model is able to prevent about 6 readmissions per year.
Mortality in Patients With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study
Creators: name: Krauss, G.L
name: Sarkis, R.
name: Lam, A.D.
name: Johnson, E.L
name: Gottesman, R.F.
name: Kucharska-Newton, A.
Publisher: name: NLM (Medline)
Year: 2021

description: BACKGROUND AND OBJECTIVES: To determine the risk of mortality and causes of death in persons with late-onset epilepsy (LOE) compared to those without epilepsy in a community-based sample, adjusting for demographics and comorbid conditions. METHODS: This is an analysis of the prospective Atherosclerosis Risk in Communities study, initiated in 1987-1989 among 15,792 mostly Black and White men and women in 4 US communities. We used Centers for Medicare & Medicaid Services fee-for-service claims codes to identify cases of incident epilepsy starting at or after age 67. We used Cox proportional hazards analysis to identify the hazard of mortality associated with LOE and to adjust for demographics and vascular risk factors. We used death certificate data to identify dates and causes of death. RESULTS: Analyses included 9,090 participants, of whom 678 developed LOE during median 11.5 years of follow-up after age 67. Participants who developed LOE were at an increased hazard of mortality compared to those who did not, with adjusted hazard ratio 2.39 (95% confidence interval 2.12-2.71). We observed excess mortality due to stroke, dementia, neurologic conditions, and end-stage renal disease in participants with compared to without LOE. Only 4 deaths (1.1%) were directly attributed to seizure-related causes. CONCLUSIONS: Persons who develop LOE are at increased risk of death compared to those without epilepsy, even after adjusting for comorbidities. The majority of this excess mortality is due to stroke and dementia.
WikiCite: Citations needed for the sum of all human knowledge
Creators: name: Mietchen, Daniel
name: Taraborelli, Dario
name: Nielsen, Finn Årup
name: Waagmeester, Andra
Publisher: name: figshare
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 80610 Information Systems Organisation
subject: Library and Information Studies
subject: FOS: Media and communications

description: Slides from the Wikimania 2017 talk.