cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Blitz Canvas: A Business Model Innovation Framework for Software Startups
Creators: name: Shanbhag, Narendranath
name: Pardede, Eric
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 461299
subject: Software engineering not elsewhere classified
classificationCode: 460999
subject: Information systems not elsewhere classified

description: Software startups are temporary organizations created with the purpose of bringing a profitable business idea to life. In the initial stages, the commercial viability of any product concept is yet to be proven and until the startup can generate revenue, resources are always in short supply. To this end, this research proposes a process-oriented, competition-aware, metric-driven business model development and innovation framework. The proposed framework is designed to aid this process, by supporting the creation and validation of the business model. A web-based tool is created to demonstrate the working of the proposed model and validation is performed using survey data collected from the usage experience of participants. The data is used to evaluate the research questions and the ability of the proposed framework to overcome the shortcomings of the business model canvas. The results showed that the tool (and by extension, the framework) made the task of business model creation a quick and easy process, while at the same time covering all the required areas to create a holistic business model. The framework contributes to startup success by creating a structured approach to business development, helping to visualize the avenues for product differentiation and planning growth.
Solvent design assisted by mechanistic insights: methods and application to peptide synthesis
Creators: name: Gui, Lingfeng
Publisher: name: Imperial College London
Year: 2023

description: Peptides are an emerging novel class of pharmaceutical agents with many potential therapeutic applications. However, during their manufacture, hazardous solvents, e.g., N,N-dimethylformamide (DMF), are frequently used, posing a major concern for process sustainability and safety. This work seeks to develop an efficient computational method of selecting and designing green alternative solvents that can achieve both high reaction efficiency and minimisation of side reactions in peptide synthesis. This method, named DoE-QM-CAMD, embeds three key components into the conventional framework of computer-aided molecular design (CAMD): a) mechanistic knowledge of a chemical reaction, b) accurate quantum mechanical (QM) modelling of reaction kinetics and c) model-based design of experiments (MBDoE). In the DoE-QM-CAMD framework, the kinetic modelling of a multi-step reaction is carried out by focusing on the key reaction species and step(s) that contribute to the underlying kinetic barrier of the whole reaction pathway, and this is guided by the mechanistic insights obtained from a computational (QM) study. Furthermore, the predictive accuracy of the original QM model is ensured through a benchmarking study. Central to DoE-QM-CAMD is the construction of an accurate surrogate model for computationally expensive QM calculations, which is trained using a minimal amount of information-rich solvent data generated from a set of judiciously designed computer experiments (i.e., QM calculations) by MBDoE. The use of the surrogate model in CAMD allows for quick identification of promising alternative solvents to DMF that experimental tests should focus on. Reassuringly, the alternatives found include two solvents already used in peptide synthesis, i.e., dichloromethane and acetonitrile, in addition to several novel solvents that have not been tested. In summary, this work provides a framework of computer-aided solvent design for optimal reaction kinetics, which also shows promise for the design of other molecules in a wider range of potential applications.
Ultrafast multi-pulse spectroscopy of hot carrier dynamics in lead halide perovskites
Creators: name: Carwithen, Ben
Publisher: name: Imperial College London
Year: 2023

description: Efficient and low-cost solutions to green energy production are vital to alleviate the damaging effects of climate change. To this end, lead halide perovskites have recently been highlighted as a novel class of materials with remarkable optoelectronic properties arising from relatively simple and cheap synthesis routes. In order to further optimise perovskite-based devices, a better understanding of their underlying photophysics is required. Herein, the intraband relaxation of above-gap charge-carriers (“hot carrier cooling”) is used as a probe of the fundamental interactions operating in bulk and nanoscale perovskites. This is achieved by employing a novel ultrafast optical approach, “pump-push-probe” spectroscopy, to isolate carrier cooling from the various other dynamics occurring on similar timescales, and separate cooling pathways mediated by carrier, phonon and trap scattering. A long-standing debate exists over the effect of quantum confinement on hot carrier dynamics in low-dimensional perovskites. The results herein, obtained via a near-infrared probe, reveal the significant role of carrier-carrier scattering, which becomes increasingly dominant with greater excitonic character of the excited state. The defect tolerance of perovskite nanocrystals is then extended to its effect on hot carrier dynamics using a visible light probe. Here, it is shown that hot carriers are not impervious to trap states in bromide-based systems, but retain this beneficial property in their iodide analogues. Finally, hot carrier mobility in a bulk perovskite single-crystal is assessed via a terahertz probe. It is shown that the response is dominated by localised lattice heating, which suppresses carrier mobility for a time period after intraband relaxation has occurred. The presented research clarifies the spectroscopic response of an important and broadly studied material class across a wide range of the electromagnetic spectrum. This will contribute to the rational design of next-generation optoelectronic devices, while aiding interpretation of overlapping photophysical processes that are otherwise difficult to disentangle.
Organic dye molecules coupling to nanocavities for single photon sources
Creators: name: Bogusz, Dominika Paula
Publisher: name: Imperial College London
Year: 2023

description: Organic dye molecules are excellent sources of indistinguishable photons and thus possess great promise for various photonic quantum technologies such as quantum computing and sensing. Our system of choice is a dibenzoterrylene (DBT) molecule in an anthracene (Ac) crystal. The molecular sources are limited, however, by a low collection efficiency (<1%) resulting in a reduction of single-photon source efficiency. That can be drastically improved through the use of optical cavities in order to collect all the photons into a single mode and accelerate the zero-phonon line radiative decay. Integrated cavities are inherently stable since they are solid-state. Placing single molecules at the correct position within a cavity significantly alters the electric field around the quantum emitter. It suppresses the unwanted emission modes and enhances the one that we choose. The emitter then preferentially emits photons into a single spatial, spectral and polarisation mode, considerably increasing its efficiency. In this thesis, I investigate various photonic structures proposed in our group or by our collaborators, each in a different stage of design, fabrication or testing. Circular Bragg gratings offer an exceptional emission redirection for collection to an objective lens, while silicon nitride nanobeam cavities and disk resonators provide a route to photon sources integrated on photonic chips. Circular Bragg grating cavities are explored in detail, including FDTD simulations of several designs with varying device materials. I also present a deterministic approach to fabricating these cavities around pre-chosen molecules that is in the final stages of development. The nanobeam cavities are optically characterised and a scheme to incorporate molecules by a hole-filling method assisted by convective-capillary forces is outlined. Disk resonators are investigated in the confocal microscope regarding both their optical properties and coupling to DBT molecules. Further work and improvements for all designs are suggested. Additionally, a vertical cavity with a Gaussian defect is proposed as a way to localise the cavity mode into an easily accessible reservoir that can be filled with molecular sources.
A record of deformation within submarine landslides and role of salt diapirism in controlling the sedimentology and distribution of deep-water deposits
Creators: name: Abu, Clara
Publisher: name: Imperial College London
Year: 2023

description: Seabed relief created by mass-transport complexes (MTCs) and salt diapirs profoundly influences the evolution and development of sediment gravity flows. The general kinematics of MTCs and their internal structure are relatively well understood. However, the multiphase, non-coaxial nature of deformation, and the dynamics of basal shear zone growth in the contractional region, both spatially and temporally, need to be better understood. I describe this thesis in two main sections; the first part uses three-dimensional seismic reflection datasets from two large passive margins (salt-influenced Kwanza Basin, offshore Angola, and the Angoche Basin, offshore Mozambique) to analyze the external and internal morphology of the MTCs, and their emplacement kinematics (section 1.2). On the Angolan margin, I conclude that the interaction between the decametre-scale rugose topography of the MTC controlled the deposition of reservoirs and channels on the slope. On the Mozambique margin, there is a minimal contractional strain within the slide body, and this may explain some of the observed structural styles in the toe region of the submarine slide. The second part of the thesis investigates the influence of passively rising diapirs on flank deformation and the resultant stratigraphic architecture of syn-kinematic units (section 1.3). Halokinetic sequences associated with flank deformation have been previously studied. However, these studies use outcrop data, needing more detailed information on sub-seismic depositional and deformational processes. Here, I identify, characterize, and deduce the controls on host rock deformation during salt diapirism by utilizing an integrated seismic, petrophysical well data, and core analysis. In the East Central Graben, North Sea, offshore UK, I conclude that core-scale evidence for large-scale fracturing is associated with drape folding in the Ekofisk Formation resulting from the diapiric salt movement. Bedding parallel slip zones and slump folds observed in the Forties Sandstone Member signifies a rotational relationship with the growing salt diapirs.
Aula-DiversidadedeSeresVivos.docx
Creators: name: Maia, Lucas
name: Bel, Renan Del
name: Dokkedal, Vinicius
name: Fujino, Gabriel
name: Talhita Justino
name: Franscisco  Cabral
Publisher: name: figshare
Year: 2015
Subjects: Education

description: Arquivo contendo descrição da aula sobre diversidade biológica referente ao curso de Internet no Ensino de ciências do curso de licenciatura em ciências biológicas da universidade de São paulo
Perceptual hashing-based client-side scanning: a flawed solution for known illegal content detection
Creators: name: Jain, Shubham
Publisher: name: Imperial College London
Year: 2023

description: End-to-end encryption (E2EE) provides strong technical protection to individuals from interference. However, governments and law enforcement agencies worldwide have raised concerns that E2EE also allows illegal content to be shared undetected. Following the global pushback against key-escrow systems, tech companies, governments, and researchers have recently proposed perceptual hashing-based client-side scanning (PH-CSS) to detect illegal content in E2EE communications. PH-CSS has raised strong privacy concerns from the security and privacy community. However, the proponents of the technology have argued that the risk is limited as the technology has a single scope: detecting known illegal content. We propose two independent threat models against the PH-CSS system. First, we propose a framework to evaluate the robustness of perceptual hashing-based client-side scanning to detect known illegal content against adversaries aiming to avoid detection by slightly modifying an image. In a large-scale evaluation, we show perceptual hashing-based client-side scanning mechanisms to be highly vulnerable to detection avoidance attacks in a black-box setting, with more than 99.9% of images successfully attacked while preserving the image's content. Second, modern perceptual hashing algorithms are fairly flexible technology. An adversary could use this flexibility to add a secondary hidden feature to a client-side scanning system. More specifically, we show that an adversary providing the PH algorithm can ''hide" a secondary purpose of facial recognition of a target individual alongside its primary purpose of detecting known illegal content. Our results show that perceptual hashing-based client-side scanning mechanisms are not robust in detecting known illegal content. They also carry the potential to be built with ''hidden" secondary purposes that could turn billions of user devices into tools to locate targeted individuals.
Prevalence of dental anxiety and fear among medical students at University of Thamar
Creators: name: Alhajj, Mohammed Nasser
Publisher: name: figshare
Year: 2015
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine

description: Fear from dental treatment is widespread distressing problem for the dentist. Anxiety may
have an impact to the dentist-patient relationship and it may cause to misdiagnosis. Therefore, this study aimed to assess the
levels of dental anxiety and fear among medical students at University of Thamar.
Online activism and redress for institutional child abuse: function and rhetoric in survivor advocacy group tweets
Creators: name: Henry, Alasdair
name: Wright, Katie
name: Moran, Anthony
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 440799
subject: Policy and administration not elsewhere classified
classificationCode: 440899
subject: Political science not elsewhere classified

description: In Australia, survivor advocacy groups have been closely engaged with the emergence and development of policy and redress responses to institutional child abuse. Their activities and influence in this respect have been under-researched. This study focuses on the use of Twitter, a tool increasingly employed by activist groups in their lobbying repertoires. Using content and thematic analysis, tweets of 15 non-survivor led advocacy groups, and one survivor-led organisation—Care Leavers Australasia Network (CLAN)—referring to ‘redress’ were analysed for rhetorical content (via Aristotle’s traditional framework of ethos, pathos, and logos) and communication purposes using three broad functional areas defined by Lovejoy and Saxton (2012). In keeping with Lovejoy and Saxton’s (2012) framework, the results found that for both non-survivor led advocacy groups and CLAN the primary function of their use of Twitter was to convey information to audiences. However, the integrated use of the rhetoric framework with the function framework revealed markedly different lobbying styles between the non-survivor led advocacy groups and CLAN with the latter pursuing a more confrontational and direct style of lobbying in communications. CLAN also overwhelmingly pursued emotion-focussed rhetoric in lobbying communications.
Online activism and redress for institutional child abuse: function and rhetoric in survivor advocacy group tweets
Creators: name: Henry, Alasdair
name: Wright, Katie
name: Moran, Anthony
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 440799
subject: Policy and administration not elsewhere classified
classificationCode: 440899
subject: Political science not elsewhere classified

description: In Australia, survivor advocacy groups have been closely engaged with the emergence and development of policy and redress responses to institutional child abuse. Their activities and influence in this respect have been under-researched. This study focuses on the use of Twitter, a tool increasingly employed by activist groups in their lobbying repertoires. Using content and thematic analysis, tweets of 15 non-survivor led advocacy groups, and one survivor-led organisation—Care Leavers Australasia Network (CLAN)—referring to ‘redress’ were analysed for rhetorical content (via Aristotle’s traditional framework of ethos, pathos, and logos) and communication purposes using three broad functional areas defined by Lovejoy and Saxton (2012). In keeping with Lovejoy and Saxton’s (2012) framework, the results found that for both non-survivor led advocacy groups and CLAN the primary function of their use of Twitter was to convey information to audiences. However, the integrated use of the rhetoric framework with the function framework revealed markedly different lobbying styles between the non-survivor led advocacy groups and CLAN with the latter pursuing a more confrontational and direct style of lobbying in communications. CLAN also overwhelmingly pursued emotion-focussed rhetoric in lobbying communications.
Bayesian large-scale structure inference with cosmological velocities and fast radio bursts
Creators: name: Prideaux-Ghee, James
Publisher: name: Imperial College London
Year: 2023

description: This thesis is concerned with extracting information about cosmology from peculiar velocities, the motion of objects induced by cosmic matter field inhomogeneities, and fast radio bursts, short-lived radio signals of unknown origin. The former provide information about the dark matter peculiar velocity field, while the latter inform about the integrated dark matter density contrast. I develop upon the Bayesian hierarchical model, BORG in order to constrain the 3D matter distribution and dynamics by including non-linear physical modelling into the reconstruction of the local peculiar field for the first time. I demonstrate this method as a proof-of-concept with simulated data, and apply it to the Second Amendment catalogue of type-1a supernovae. I study the statistics of the dark matter velocity dispersion tensor, which is an avenue to study the behaviour of objects undergoing gravitational collapse. In particular, I investigate how the statistics of the velocity dispersion vary as a function of simulation and cosmological parameters. I further explore the behaviour of the distributions of the velocity dispersion conditional on density. These provide a method to include velocity dispersion information into velocity field reconstructions. Lastly, I explore what cosmological information can be extracted from existing fast radio burst datasets. For the first time, these bursts are modelled as existing within an inhomogeneous universe. The method of Bayesian inference is used to constrain cosmological parameters from a set of localised and a set of unlocalised fast radio bursts. Furthermore, I demonstrate a proof-of-concept method for constraining the dark matter initial conditions using these bursts, finding that we will need at least three orders of magnitude more data than currently exists. I also investigate using these bursts to augment conventional datasets used in initial conditions inference, demonstrating that, with sufficient bursts, their addition can improve our knowledge of the initial conditions.
The Role of Soil Microbial Diversity in the Conservation of Native Seed Bacterial Microbiomes
Creators: name: Chandel, Ankush
name: Mann, R
name: Kaur, J
name: Norton, S
name: Auer, D
name: Edwards, Jacqueline
name: Spangenberg, German
name: Sawbridge, Tim
Publisher: name: La Trobe
Year: 2022

description: Research into understanding the structure, composition and vertical transmission of crop seed microbiomes has intensified, although there is much less research into the seed microbiomes of crop wild relatives. Our previous study showed that the standard seed storage procedures (e.g., seed drying and storage temperature) can influence the seed microbiome of domesticated Glycine max. In this study, we characterized the seed microbiota of Glycine clandestina, a perennial wild relative of soybean (G. max (L.) Merr.) to expand our understanding about the effect of other storage procedures such as the periodic regeneration of seed stocks to bulk up seed numbers and secure viability on the seed microbiome of said seed. The G. clandestina microbiota was analysed from Generation 1 (G1) and Generation 2 (G2) seed and from mature plant organs grown in two different soil treatments T (treatment [native soil + potting mix]) and C (control [potting mix only]). Our dataset showed that soil microbiota had a strong influence on next generation seed microbiota, with an increased contribution of root microbiota by 90% and seed transmissibility by 36.3% in G2 (T) seed. Interestingly, the G2 seed microbiota primarily consisted of an initially low abundance of taxa present in G1 seed. Overall, our results indicate that seed regeneration can affect the seed microbiome composition and using native soil from the location of the source plant can enhance the conservation of the native seed microbiota.
title: 01_1651
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: LaMOP

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
MPEC 2024-L111 : 2024 LX2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 LX2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
A Educação a Distância na Universidade Salvador – UNIFACS Um Relato de Aspectos de Evolução da Área
Creators: name: Neto, Guilerme Marback
name: Martins, Joberto S. B.
name: Quadros, Terezinha G. T.
Publisher: name: Zenodo
Year: 2008
Subjects: Educação a Distância
EAD
Tecnologias da Informação e Comunicação
TIC
UNIFACS
Núcleo de Pesquisa e Projetos em Educação a Distância
NUPPEAD
Currículo EAD
Processo EAD
Implantação EAD
Modelos e Práticas do EAD
Polos e Atuação EAD

description: O objetivo deste texto é a apresentação de forma resumida de alguns dos elementos que pautaram a evolução histórica da Educação a Distância na Universidade Salvador (EAD UNIFACS) desde 1999, ano de sua implantação.
description: {"references": ["Ribeiro, Otac\u00edlio Jos\u00e9: Educa\u00e7\u00e3o e novas tecnologias: um olhar para al\u00e9m da t\u00e9cnica. In Coscarelli, Carla Viana & Ribeiro, Ana Elisa (Orgs). Letramento digital: Aspectos sociais e possibilidades pedag\u00f3gicas. Belo Horizonte: Ceale, Aut\u00eantica, 20", "Perrenoud, Philippe. Dez novas compet\u00eancias para ensinar. Porto Alegre: Artes M\u00e9dicas Sul, 2000.", "MARTINS, Joberto S B; MARBACK, Guilherme. Evaluating by Experience the Role of Teachers and Tutors in Distance Learning Education. In: : _______. IFIP World Conference on Computers in Education - WCCE 2005. Cape Town, 2005.", "MARTINS, Joberto S B et al. The Challenge of Creating and Establishing the Role of Online and Virtual Learning Environments for All. In: _______. IFIP Working Group 3.2 & 3.4 Workshop - Information and Communication Technologies (ICT) and Real-life Learning. Melbourne: Springer, 2005. p. 277-282.", "MARTINS, Joberto S B; QUADROS, T. Experiences and Practices in Modeling Distance Learning Curricula for Capillary Approaches and Limited ICT Resource Scenarios. In:_______. IFIP Working Group 3.2 & 3.4 Workshop - Information and Communication Technologies (ICT) and Real-life Learning. Melbourne: Springer, 2004. p. 55-66.", "MARTINS, Joberto S B; MARBACK, Guilherme; BRITO, S\u00e9rgio. Interdisciplinary and Flexible Curr\u00edcula Practices in Eletric and Telecommuncations Engineering - A Case Study. In:_______. IFIP Working Group 3.2 Conference - Informatics and ICT in Higher Education - ICTEM 2002. Florianopolis: Editora UFSC, 2002", "MORAN, Jos\u00e9 Manuel. Tend\u00eancias da Educa\u00e7\u00e3o On-line no Brasil. In: RICARDO, Eleonora Jorge. (Org.). Educa\u00e7\u00e3o Corporativa e Educa\u00e7\u00e3o a Dist\u00e2ncia. Rio De Janeiro: Qualitymark, 2005. p. 3-24.", "QUADROS, Teresinha, MARTINS, Joberto S. B. A Pr\u00e1tica Interdisciplinar em Programas de Educa\u00e7\u00e3o a Dist\u00e2ncia num Cen\u00e1rio de Novas Tecnologias da Informa\u00e7\u00e3o e Comunica\u00e7\u00e3o. In: Anais do XVI Simp\u00f3sio Brasileiro de Inform\u00e1tica na Educa\u00e7\u00e3o. SBIE 2005, Juiz de Fora: Universidade Federal de Juiz de Fora, 2005. p. 351-361."]}
Automated methods to find high-redshift quasars
Creators: name: Lenz, Lena
Publisher: name: Imperial College London
Year: 2023

description: Quasars are among the most luminous objects in the Universe and as such can be found to have existed within the first 700 million years after the Big Bang. This makes them useful for analyzing the epoch of reionisation and the black hole mass evolution. They can be identified by a distinct break in their spectral energy distribution (SED) around Lyα, which shifts into the near-infrared at z ≳ 6.5. However, due to their rarity and large contaminating populations, only a handful of quasars at z > 7 have been found in total so far. Current methods contain visual inspection of images from photometric surveys as part of the classification process. Manually examining a significant part of the candidates becomes infeasible for upcoming surveys such as the Large Synoptic Survey Telescope (LSST) and Euclid, which are expected to produce ∼ 1011 − 1012 bytes of data each night. In this work, we reduce the amount of required visual inspection by testing candidates against a model of a stationary point source that follows a quasar SED at 5.2 ≲ z ≲ 12. Bayesian model comparison based on colour information is used to retrieve a quasar probability and the best fit SED. To automate this process, we implement a data processing pipeline that extracts relevant information from survey databases and photometric images. This information is then used to apply heuristic cuts in order to obtain high-redshift quasar candidates. To optimise the classification, the collected information is passed to decision tree and random forest machine learning classifiers. We also feed the raw image data to a convolutional neural network to compare performance. Our pipeline is implemented for the Sloan Digital Sky Survey (SDSS) and the United Kingdom Infrared Telescope Infrared Deep Sky Survey (UKIDSS), and can easily be extended to future surveys.
Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86
Creators: name: Liu, H
name: Wilson, KR
name: Firth, AM
name: Macri, C
name: Schriek, P
name: Blum, AB
name: Villar, J
name: Wormald, S
name: Shambrook, Mitch
name: Xu, B
name: Lim, HJ
name: McWilliam, HEG
name: Hill, Andrew
name: Edgington-Mitchell, LE
name: Caminschi, I
name: Lahoud, MH
name: Segura, E
name: Herold, Marco
name: Villadangos, JA
name: Mintern, JD
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 320499
subject: Immunology not elsewhere classified

description: The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, molecules of critical importance to immunity. Here we show, using a genome-wide CRISPR knockout screen, that ubiquitin-like protein 3 (UBL3) is a necessary component of ubiquitination-mediated trafficking of these molecules in mice and in humans. Ubl3-deficient mice have elevated MHC II and CD86 expression on the surface of professional and atypical antigen presenting cells. UBL3 also regulates MHC II and CD86 in human dendritic cells (DCs) and macrophages. UBL3 impacts ubiquitination of MARCH1 substrates, a mechanism that requires UBL3 plasma membrane anchoring via prenylation. Loss of UBL3 alters adaptive immunity with impaired development of thymic regulatory T cells, loss of conventional type 1 DCs, increased number of trogocytic marginal zone B cells, and defective in vivo MHC II and MHC I antigen presentation. In summary, we identify UBL3 as a conserved, critical factor in MARCH1-mediated ubiquitination with important roles in immune responses.
Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86
Creators: name: Liu, H
name: Wilson, KR
name: Firth, AM
name: Macri, C
name: Schriek, P
name: Blum, AB
name: Villar, J
name: Wormald, S
name: Shambrook, Mitch
name: Xu, B
name: Lim, HJ
name: McWilliam, HEG
name: Hill, Andrew
name: Edgington-Mitchell, LE
name: Caminschi, I
name: Lahoud, MH
name: Segura, E
name: Herold, MJ
name: Villadangos, JA
name: Mintern, JD
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 320499
subject: Immunology not elsewhere classified

description: The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, molecules of critical importance to immunity. Here we show, using a genome-wide CRISPR knockout screen, that ubiquitin-like protein 3 (UBL3) is a necessary component of ubiquitination-mediated trafficking of these molecules in mice and in humans. Ubl3-deficient mice have elevated MHC II and CD86 expression on the surface of professional and atypical antigen presenting cells. UBL3 also regulates MHC II and CD86 in human dendritic cells (DCs) and macrophages. UBL3 impacts ubiquitination of MARCH1 substrates, a mechanism that requires UBL3 plasma membrane anchoring via prenylation. Loss of UBL3 alters adaptive immunity with impaired development of thymic regulatory T cells, loss of conventional type 1 DCs, increased number of trogocytic marginal zone B cells, and defective in vivo MHC II and MHC I antigen presentation. In summary, we identify UBL3 as a conserved, critical factor in MARCH1-mediated ubiquitination with important roles in immune responses.
Spatiotemporal modelling of all-cause and cause-specific mortality in England
Creators: name: Rashid, Theo
Publisher: name: Imperial College London
Year: 2023

description: High-resolution data for changes in mortality and longevity are scarce. Estimating mortality for specific combinations of spatial units, time periods, age groups, and causes of death poses statistical and computational challenges which typically result in compromises in the granularity of the results. I applied Bayesian hierarchical models based on patterns of mortality over age, space, and time, to obtain robust yearly estimates of life expectancy and cause-specific mortality for small areas. Using vital registration data held by the UK Small Area Health Statistics Unit, I investigated trends in mortality for subnational units in England from 2002 to 2019. I examined trends in life expectancy in England's 6791 middle-layer super output areas (MSOAs). In the years 2014-19, 1270 (18.7%) MSOAs for women and 784 (11.5%) MSOAs for men saw declines in life expectancy. The same analysis was performed for the 4835 lower-layer super output areas which comprise London. At this smaller level, issues with the population data in the older age groups affected the reliability of the life expectancy estimates. I modelled cause-specific mortality for 314 districts in England. The inequality in life expectancy increase since 2010 was driven largely by that of deaths from dementias and the residual group of non-communicable diseases, as well as ischaemic heart disease in men. The analysis was extended to look specifically at the top ten leading cancer causes of death. Preventable cancers showed the greatest spatial inequality in 2019. Unlike areas in the rest of the country, mortality in London from several cancers did not increase in poorer districts, suggesting that some features of London weaken the relationship between poverty and mortality. England has seen increasing inequalities in all-cause mortality over the past two decades, driven by rises in mortality for a large number of communities and from several preventable causes of death.
ARQUITETURA MODULAR E ESCALÁVEL PARA DESENVOLVIMENTO DE APLICATIVOS MÓVEIS NO ESCRITÓRIO DE SOLUÇÕES CRIATIVAS
Creators: name: Rafael Aguiar SILVA
name: Jeferson Morais da COSTA
Publisher: name: Zenodo
Year: 2024
Subjects: Arquitetura de software
Design de software
Componentes de software
Multiplataforma
Desenvolvimento móvel.

description: RESUMO

Arquitetura de software é algo imprescindível para construir qualquer sistema de software escaláveis, testáveis e de fácil manutenção. No entanto nem sempre ela é implementada nos projetos do Escritório de Soluções Criativas (ESC), seja por falta de conhecimento ou por ignorar alguns aspectos importantes do processo de construção. Diante desse cenário, foi idealizado uma proposta para desenvolver uma arquitetura de software para construção de aplicativos moveis. A arquitetura irá conter um esqueleto de organização de pastas e arquivos, assim com um sistema de rotas e módulos embutidos, também virá com as camadas de busca e transformações de dados, tradução e gerenciamento de estados. Todo esse acervo estará disponível no repositório interno do ESC, no qual será disponibilizado para os desenvolvedores. Dessa forma busca-se maximizar a qualidade do desenvolvimento e a qualidade das entregas.
Clinician perspectives on voluntary assisted dying and willingness to be involved: a multisite, cross-sectional survey during implementation in New South Wales, Australia
Creators: name: Light, E
name: Kerridge, I
name: Skowronski, G
name: Venkatesha, V
name: Krishnamurthy, A
name: Kuper, S
name: Noonan, Kerrie
name: Hoyle, P
name: Arnold, M
name: Manley, S
name: Stedman, W
name: Sheahan, L
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 420316
subject: Palliative care
classificationCode: 4203
subject: Health services and systems
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background: In the context of nationwide law reform, New South Wales (NSW) became the last state in Australia to legalise voluntary assisted dying (VAD) – commencing 28 November 2023. Clinicians have divergent views regarding VAD, with varying levels of understanding, support, and willingness to be involved, and these may have a significant impact on the successful implementation. Aims: To understand levels of support, understanding and willingness to be involved in VAD among clinical staff across NSW during implementation of VAD. Methods: A multisite, cross-sectional online survey of clinicians across four local health districts, assessing relevant demographics, awareness of and support for VAD legislation and willingness to be involved in different levels of VAD-related clinical activities. Results: A total of 3010 clinical staff completed the survey. A majority of participants were aware of VAD legislation in NSW (86.35%) and supportive of it (76%), with nursing and allied health clinicians significantly more likely than medical specialists to express support. Among medical specialists, support was statistically more likely in those who did not care for patients at the end of life and those with limited knowledge of the legislation. Willingness of medical specialists to perform key roles was significantly lower, with 41.49% willing to act in coordinating or consulting roles, and only 23.21% as administering practitioners. Conclusions: The majority of clinical staff surveyed across NSW supported VAD legislation. While many eligible clinicians were reluctant to be actively involved, sufficient numbers appear willing to provide VAD services, indicating that successful implementation should be possible.
Using mid-infrared spectroscopy to increase GWAS power to detect QTL associated with blood urea nitrogen
Creators: name: van den Berg, I
name: Ho, PN
name: Nguyen, TV
name: Haile-Mariam, Mekonnen
name: Luke, TDW
name: Pryce, Jennie
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 310599
subject: Genetics not elsewhere classified

description: Blood urea nitrogen (BUN) is an indicator trait for urinary nitrogen excretion. Measuring BUN level requires a blood sample, which limits the number of records that can be obtained. Alternatively, BUN can be predicted using mid-infrared (MIR) spectroscopy of a milk sample and thus records become available on many more cows through routine milk recording processes. The genetic correlation between MIR predicted BUN (MBUN) and BUN is 0.90. Hence, genetically, BUN and MBUN can be considered as the same trait. The objective of our study was to perform genome-wide association studies (GWAS) for BUN and MBUN, compare these two GWAS and detect quantitative trait loci (QTL) for both traits, and compare the detected QTL with previously reported QTL for milk urea nitrogen (MUN). The dataset used for our analyses included 2098 and 18,120 phenotypes for BUN and MBUN, respectively, and imputed whole-genome sequence data. The GWAS for MBUN was carried out using either the full dataset, the 2098 cows with records for BUN, or 2000 randomly selected cows, so that the dataset size is comparable to that for BUN. The GWAS results for BUN and MBUN were very different, in spite of the strong genetic correlation between the two traits. We detected 12 QTL for MBUN, on bovine chromosomes 2, 3, 9, 11, 12, 14 and X, and one QTL for BUN on chromosome 13. The QTL detected on chromosomes 11, 14 and X overlapped with QTL detected for MUN. The GWAS results were highly sensitive to the subset of records used. Hence, caution is warranted when interpreting GWAS based on small datasets, such as for BUN. MBUN may provide an attractive alternative to perform a more powerful GWAS to detect QTL for BUN.
¿Como la vinchuca me transmite Chagas?
Creators: name: Lardeux, Frederic
name: Torrez, Libia
name: Buhezo, Wendy
Publisher: name: Laboratorio de Entomologia Medica, Universidad Mayor de San Simon, Bolivia
Year: 2021
Subjects: Chagas
transmission
Trypanosoma cruzi
Bolivia
Chaco boliviano
CHAGLAG

description: Poster réalisé  dans le cadre du programme de recherche CHAGLAG « “Estudio piloto de la enfermedad de Chagas en comunidades Guaraníes de Lagunillas” (2018-2021), réalisé par l’ IRD (Institut de Recherche pour le Développement, Cooperación de Francia) et le Laboratorio de Entomología Médica de la UMSS (Universidad Mayor de San Simon, Cochabamba, Bolivia) ; financé par l’IRD (Institut de Recherche pour le Développement, Cooperación de Francia), TOTAL E&P Bolivia (TOTAL Energies) et la CAF-Bolivia (Banco de Desarrollo de América Latina, Corporación Andina de Fomento).

Le poster est à destination des villageois, habitants des villages ruraux du Chaco Boliviano et a servi de matériel didactique à des "férias de salud" (foires de la santé) dans la zone du projet CHAGLAG (zone de Lagunillas, Chaco Boliviano), en 2021
Using mid-infrared spectroscopy to increase GWAS power to detect QTL associated with blood urea nitrogen
Creators: name: van den Berg, I
name: Ho, PN
name: Nguyen, TV
name: Haile-Mariam, M
name: Luke, TDW
name: Pryce, Jennie
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310599
subject: Genetics not elsewhere classified

description: Blood urea nitrogen (BUN) is an indicator trait for urinary nitrogen excretion. Measuring BUN level requires a blood sample, which limits the number of records that can be obtained. Alternatively, BUN can be predicted using mid-infrared (MIR) spectroscopy of a milk sample and thus records become available on many more cows through routine milk recording processes. The genetic correlation between MIR predicted BUN (MBUN) and BUN is 0.90. Hence, genetically, BUN and MBUN can be considered as the same trait. The objective of our study was to perform genome-wide association studies (GWAS) for BUN and MBUN, compare these two GWAS and detect quantitative trait loci (QTL) for both traits, and compare the detected QTL with previously reported QTL for milk urea nitrogen (MUN). The dataset used for our analyses included 2098 and 18,120 phenotypes for BUN and MBUN, respectively, and imputed whole-genome sequence data. The GWAS for MBUN was carried out using either the full dataset, the 2098 cows with records for BUN, or 2000 randomly selected cows, so that the dataset size is comparable to that for BUN. The GWAS results for BUN and MBUN were very different, in spite of the strong genetic correlation between the two traits. We detected 12 QTL for MBUN, on bovine chromosomes 2, 3, 9, 11, 12, 14 and X, and one QTL for BUN on chromosome 13. The QTL detected on chromosomes 11, 14 and X overlapped with QTL detected for MUN. The GWAS results were highly sensitive to the subset of records used. Hence, caution is warranted when interpreting GWAS based on small datasets, such as for BUN. MBUN may provide an attractive alternative to perform a more powerful GWAS to detect QTL for BUN.
Romance nuevo del chasco que le dio una vieja a un mancebo: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Romance nuevo del chasco que le dio una vieja a un mancebo: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Romance nuevo del chasco que le dio una vieja a un mancebo: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Parents' management of alcohol in the context of discourses of 'competent' parenting: A qualitative analysis
Creators: name: Cook, Megan
name: Pennay, Amy
name: MacLean, Sarah
name: Dwyer, Robyn
name: Mugavin, Janette
name: Callinan, Sarah
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified
classificationCode: 441099
subject: Sociology not elsewhere classified

description: How parents manage potential tensions between normative discourses of 'competent parenting' and their desires to consume alcohol has received little attention. In this article, we explore the elements that encourage or constrain parents' drinking and investigate how parents consider and manage their alcohol use in the context of multiple social roles with sometimes conflicting demands and expectations around 'competent parenting'. Our analysis draws on 30 semi-structured interviews with Australian parents, conducted as part of a broader project which aimed to explore how home drinking is integrated into everyday life. While parents' accounts of drinking alcohol highlighted effects such as embodied experiences of relaxation and facilitating shared adult moments, many participants described drinking less than they otherwise would if their children were not present. Participants discussed various social roles and routines which constrained consumption, with drinking bounded by responsibility. As such, drinking emerged as something needing to be actively negotiated, particularly in light of discourses that frame expectations of what constitutes 'competent parenting'. When considering parents' alcohol consumption in the future, we argue that it is important to destigmatise their consumption by acknowledging the importance of adults' pleasure and wellbeing, alongside children's needs for safety and modelling of safer alcohol consumption.