cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Make Your Own Kind of Music?
Creators: name: Voit, Johannes
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: Im vorliegenden Beitrag wird der Versuch unternommen, die von der New London Group für den Fremdsprachenunterricht vorgeschlagene Konzeption einer Pädagogik der Multiliteracies für den musikpädagogischen Diskurs fruchtbar zu machen. Dabei wird an die Vorstellung von Musik als sozialer Praxis angeknüpft, die in der wissenschaftlichen Musikpädagogik in den vergangenen zwei Jahrzehnten zunehmende Verbreitung gefunden hat. Im Zentrum steht die Fragestellung, welche Implikationen sich aus dem Konzept der Multiliteracies für produktionsdidaktische Kontexte ableiten lassen. Hierzu werden zunächst Ergebnisse einer empirischen Studie über Response-Projekte vorgestellt, die das Spannungsfeld deutlich machen, in dem sich Komponist*innen befinden, wenn sie einerseits Schüler*innen möglichst große ästhetische Freiräume gewähren und sie andererseits an eine bestimmte kompositorische Praxis heranführen möchten. Anschließend werden die Ergebnisse in den zuvor entfalteten theoretischen Kontext eingebettet und diskutiert.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
Discrimination between Translesion Synthesis and Template Switching during Bypass Replication of Thymine Dimers in Duplex DNA
Creators: name: Cordeiro-Stone, Marila
name: Nikolaishvili-Feinberg, Nana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The goal of this study was to determine whether bypass replication occurs by translesion synthesis or template switching (copy choice) when a duplex molecule carrying a single cis,syn-cyclobutane thymine dimer is replicated in vitro by human cell extracts. Circular heteroduplex DNA molecules were constructed to contain the SV40 origin of replication and a mismatch opposite to or nearby the dimer. Control molecules with only the mismatch were also prepared. Heteroduplexes were methylated at CpG islands and replicated in vitro (30 min). Following bisulfite treatment, the nascent DNA complementary to the dimer-containing template was distinguished from the other three strands by methylation-specific polymerase chain reaction. Cloning and sequencing of polymerase chain reaction products revealed that 80-98% carried the sequence predicted for translesion synthesis, with two adenines incorporated opposite the dimer. The fraction of clones with sequence predictive of template switching was reduced when extracts deficient in mismatch repair or nucleotide excision repair activities were used to replicate the heteroduplex molecules. These results support the conclusion that lesion bypass during in vitro replication of duplex DNA containing thymine dimers occurs by translesion synthesis.
Begegnungen von Religionen als Thema des Lateinunterrichts
Creators: name: Freund, Stefan
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: In der Diskussion um interkulturelle Bildung erscheinen Religion und religiös-kulturelle Diversität zwar im Hintergrund geradezu omnipräsent, angesprochen werden sie jedoch oft nicht – so etwa in der KMK-Leitlinie „Interkulturelle Bildung und Erziehung in der Schule“. Die römische Antike weist ein breites Spektrum von Erscheinungsformen des Religiösen auf: die Staatsre- ligion, die Mythologie, die alltägliche Frömmigkeit und den philosophischen Diskurs über die Götter, später dann die Auseinandersetzung zwischen dem Christentum und dem römischen Staat bzw. der paganen Kultur, aus der sich in der Synthese von Antikem und Jüdisch-Christlichem ein wesentliches Substrat für die europäische Kultur ergibt. Der Beitrag versucht, ausgehend von der Realität des multireligiösen Klassenzimmers und anknüpfend an Konzepte interreligiösen Lernens, aufzuweisen, dass der Lateinunterricht ein großes Poteztial nicht nur interkultureller, sondern auch interreligiöser Lerngelegenheiten aufweist, und formuliert Anregungen zu deren Nutzung.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
Supplementary Figure 1 from Acorn worm ossicle ultrastructure and composition and the origin of the echinoderm skeleton
Creators: name: Larouche-Bilodeau, Charles
name: Cameron, Christopher B.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Saccoglossus kowalevskii ossicle width and length proportion.
Wenn familia nicht Familie bedeutet
Creators: name: Janssen, Leoni
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: Angesichts einer zunehmend heterogenen Schüler*innenschaft sind die Themen kultureller, interkultureller und transkultureller Bildung sowie der Mehrsprachigkeit aus aktuellen sprachdidaktischen Diskussionen nicht mehr wegzudenken. In der Lateindidaktik wurde jedoch bisher kaum grundlegend aufgearbeitet, was unter kulturellem, interkulturellem und transkulturellem Lernen im Kontext von Spracherwerb und Mehrsprachigkeit zu verstehen ist oder wie diese Ansätze in den Elementarunterricht implementiert werden können. Der vorliegende Artikel widmet sich der Verbindung von Sprache und Kultur und stellt ein erstes Modell vor, das kulturelles, interkulturelles und transkulturelles Lernen an das Verständnis und die Reflexion von Lehrbuchtexten anbindet. Eine zentrale Rolle in diesem Modell nimmt die Hotword-Methode aus dem Fach Deutsch als Fremdsprache ein, mit welcher auf kulturelle Deutungsmuster in den Konzepten lateinischer Vokabeln fokussiert werden kann.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
Disruption of the A 3 Adenosine Receptor Gene in Mice and Its Effect on Stimulated Inflammatory Cells
Creators: name: Jacobson, Marlene A.
name: Salvatore, Christopher A.
name: Latour, Anne M.
name: Tilley, Stephen L.
name: Koller, Beverly H.
name: Fletcher, Daniel S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The A(3) adenosine receptor (A3AR) is one of four receptor subtypes for adenosine and is expressed in a broad spectrum of tissues. In order to study the function of A3AR, a mouse line carrying a mutant A(3) allele was generated. Mice homozygous for targeted disruption of the A3AR gene, A3AR(-/-), are fertile and visually and histologically indistinguishable from wild type mice. The lack of a functional receptor in the A3AR(-/-) mice was confirmed by molecular and pharmacological analyses. The absence of A3AR protein expression in the A3AR(-/-) mice was demonstrated by lack of N(6)-(4-amino-3-[(125)I]iodobenzyl)adenosine binding to bone marrow-derived mast cell membranes that were found to express high levels of A3AR in wild type mice. In A3AR(-/-) mice, the density of A(1) and A(2A) adenosine receptor subtypes was the same as in A3AR(+/+) mice as determined by radioligand binding to brain membranes. Additionally, A(2B) receptor transcript expression was not affected by ablation of the A3AR gene. A3AR(-/-) mice have basal heart rates and arterial blood pressures indistinguishable from A3AR(+/+) mice. Functionally, in contrast to wild type mice, adenosine and the A3AR-specific agonist, 2-chloro-N(6)-(3-iodobenzyl)-adenosine-5'-N-methyl-carboxamide (2-Cl-IB-MECA), elicit no potentiation of antigen-dependent degranulation of bone marrow-derived mast cells from A3AR(-/-) mice as measured by hexosaminidase release. Also, the ability of 2Cl-IB-MECA to inhibit lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo was decreased in A3AR(-/-) mice in comparison to A3AR(+/+) mice. The A(2A) adenosine receptor agonist, 2-p-(2-carboxyethyl)phenylamino)-5'-N-ethylcarboxamidoadenosine, produced inhibition of lipopolysaccharide-stimulated tumor necrosis factor-alpha production in both A3AR(-/-) and A3AR(+/+) mice. These results show that the inhibition in vivo can be mediated by multiple subtypes, specifically the A(3) and A(2A) adenosine receptors, and A3AR activation plays an important role in both pro- and anti-inflammatory responses.
Re-examining the case for neutral gas near the redshift 7 quasar ULAS J1120+0641
Creators: name: Bosman, Sarah E. I.
name: Becker, George D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Signs of damping wing absorption attenuating the Lyman-$α$ emission line of the first known $z \sim 7$ quasar, ULAS J1120+0641, recently provided exciting evidence of a significantly neutral IGM. This long-awaited signature of reionization was inferred, in part, from a deficit of flux in the quasar's Lyman-$α$ emission line based on predictions from a composite of lower-redshift quasars. The composite sample was chosen based on its C IV emission line properties; however, as the original study by Mortlock et al. noted, the composite contained a slight velocity offset in C IV compared to ULAS J1120+0641. Here we test whether this offset may be related to the predicted strength of the Lyman-$α$ emission line. We confirm the significant ($\sim 10$ per cent at r.m.s.) scatter in Lyman-$α$ flux for quasars of a given C IV velocity and equivalent width found by Mortlock et al. We further find that among lower-redshift objects chosen to more closely match the C IV properties of ULAS J1120+0641, its Lyman-$α$ emission falls within the observed distribution of fluxes. Among lower-redshift quasars chosen to more closely match in C IV velocity and equivalent width, we find that ULAS J1120+0641 falls within the observed distribution of Lyman-$α$ emission line strengths. This suggests that damping wing absorption may not be present, potentially weakening the case for neutral gas around this object. Larger samples of z$>$7 quasars may therefore be needed to establish a clearer picture of the IGM neutral fraction at these redshifts.
description: 7 pages, 6 figures
Semi-quantitative analysis for target ZnFe2O4 from Microstructure, local electronic structure and optical behaviour of zinc ferrite thin films on glass substrate.
Creators: name: Jitendra Pal Singh
name: Byeong-Hyeon Lee
name: Lim, Weon Cheol
name: Cheol-Hwee Shim
name: Jihye Lee
name: Chae, Keun Hwa
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30606 Structural Chemistry and Spectroscopy
subject: 30699 Physical Chemistry not elsewhere classified

description: JPS-Table S1
Transkulturelle Kompetenz im Spanischunterricht
Creators: name: Gerling, Vera Elisabeth
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: Der Spanischunterricht bietet viel Anschauungsmaterial, um in heterogenen, schulischen Lernsettings über Fragen von Identität und Zugehörigkeit bewusst und selbstkritisch nachzudenken. Dieser Beitrag möchte darstellen, wie das Übersetzen sowohl als literarisches Phänomen als auch als didaktische Methode eine Reflexion über die Normvorstellungen von Kultur, Sprache und Identität anregen kann. Die Lyrik von Rosario Ferré bietet sich für eine inhaltliche Erschließung der Thematik Migration und Kulturkontakt in besonderer Weise an. Darüber hinaus ist es möglich, durch eine Konfrontation mit dem literarischen Werk und insbesondere seiner sprachlichen Hybridität transkulturelle Phänomene ästhetisch erfahrbar zu machen.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
BO'LAJAK TEXNOLOGIYA O'QITUVCHILARIDA KASBIY KOMPETENTLIKNING RIVOJLANTIRISH USULLARI
Creators: name: Rahmatova, Barnogul
Publisher: name: Zenodo
Year: 2023

description: Kasbiy kompetentlik – mutaxassis tomonidan kasbiy faoliyatni amalga oshirish uchun kerak bo'lgan bilim, ko'nikma va malakalarning egallanishi va ularni amalda yuqori darajada qo'llay olinishini anglatadi.
Operating between Cultures and Langugages: Multilingual Films in Foreign Language Classes
Creators: name: Blell, Gabriele
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: Our societies have undergone two major changes during the last decades: firstly, the continuous rise of cultural and linguistic diversity, due to the global economy, migration and universal mobility, and secondly, the steady expansion and gathering impetus of the new communication media (Cope & Kalantzis, 2000, 2012). In consequence, multilingualism, acquired or learned, has shaped our living together and pertains to our learners in the classroom. Similarly, polyglot movies, literatures and other cultural productions have become symbolic expressions for worldwide cross-cultural movements for all age groups. Both the multilingualism and the multi-/transculturalism inherent in the texts and images constitute a rich cultural resource for the Foreign Language (FL) classroom. This article argues that the creative potential of transnational film, to be found in its multilingualism and transculturalism, should be used as a complementary field of teaching film beyond the traditional and curriculum-bound (English only) English as a Foreign Language (EFL) classroom in Germany and therefore supports multicultural, multilingual and multimodal learning. The article uses examples from Quentin Ta­rantino’s Inglourious Basterds (2009), Gonzalez Iñarritu’s Babel (2012) and Wim Wenders’ documentary Pina (2011).
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
Heavy-fermion valence-bond liquids in ultracold atoms: Cooperation of Kondo effect and geometric frustration
Creators: name: Isaev, L.
name: Rey, A. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We analyze a microscopic mechanism behind coexistence of a heavy Fermi liquid and geometric frustration in Kondo lattices. We consider a geometrically frustrated periodic Anderson model and demonstrate how orbital fluctuations lead to a Kondo-screened phase in the limit of extreme strong frustration when only local {\it singlet} states participate in the low-energy physics. We also propose a setup to realize and study this exotic state with $SU (3)$-symmetric alkaline-earth cold atoms.
Elucidation of Binding Determinants and Functional Consequences of Ras/Raf-Cysteine-rich Domain Interactions
Creators: name: Williams, Jason G.
name: Clark, Geoffrey J.
name: Der, Channing J.
name: Campbell, Sharon L.
name: Drugan, Jonelle K.
name: Yi, Gwan Su
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Raf-1 is a critical downstream target of Ras and contains two distinct domains that bind Ras. The first Ras-binding site (RBS1) in Raf-1 has been shown to be essential for Ras-mediated translocation of Raf-1 to the plasma membrane, whereas the second site, in the Raf-1 cysteine-rich domain (Raf-CRD), has been implicated in regulating Raf kinase activity. While recognition elements that promote Ras.RBS1 complex formation have been characterized, relatively little is known about Ras/Raf-CRD interactions. In this study, we have characterized interactions important for Ras binding to the Raf-CRD. Reconciling conflicting reports, we found that these interactions are essentially independent of the guanine nucleotide bound state, but instead, are enhanced by post-translational modification of Ras. Specifically, our findings indicate that Ras farnesylation is sufficient for stable association of Ras with the Raf-CRD. Furthermore, we have also identified a Raf-CRD variant that is impaired specifically in its interactions with Ras. NMR data also suggests that residues proximal to this mutation site on the Raf-CRD form contacts with Ras. This Raf-CRD mutant impairs the ability of Ras to activate Raf kinase, thereby providing additional support that Ras interactions with the Raf-CRD are important for Ras-mediated activation of Raf-1.
Escherichia coli MutL Loads DNA Helicase II onto DNA
Creators: name: Matson, Steven W.
name: Mechanic, Leah E.
name: Frankel, Brenda A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Previous studies have shown that MutL physically interacts with UvrD (DNA helicase II) (Hall, M. C., Jordan, J. R., and Matson, S. W. (1998) EMBO J. 17, 1535-1541) and dramatically stimulates the unwinding reaction catalyzed by UvrD in the presence and absence of the other protein components of the methyl-directed mismatch repair pathway (Yamaguchi, M., Dao, V., and Modrich, P. (1998) J. Biol. Chem. 273, 9197-9201). The mechanism of this stimulation was investigated using DNA binding assays, single-turnover helicase assays, and unwinding assays involving long duplex DNA substrates. The results indicate that MutL binds DNA and loads UvrD onto the DNA substrate. The interaction between MutL and DNA and that between MutL and UvrD are both important for stimulation of UvrD-catalyzed unwinding. MutL does not clamp UvrD onto the substrate; and therefore, the processivity of unwinding is not increased in the presence of MutL. The implications of these results are discussed, and models are presented for the mechanism of MutL stimulation as well as for the role of MutL as a master coordinator in the methyl-directed mismatch repair pathway.
Standards – Margins – New Horizons: Einleitung
Creators: name: Schildhauer, Peter
name: Sauer, Jochen
name: Schröder, Anne
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: Ausgehend von den Befunden der New London Group, die tiefgreifende Veränderungen im Arbeitsleben, im Privatleben und im öffentlichen Leben in der westlichen Gesellschaft feststellte, widmet sich der Sammelband der Frage, wie Fremdsprachenunterricht im 21. Jahrhundert in den neuen und alten Sprachen gestaltet werden soll. Im Vordergrund stehen die Fragen, auf welche Weise Lernende auf die zunehmend komplexen kommunikativen Herausforderungen vorbereitet werden können, die eine kulturell diversifizierte Welt bietet, und wie gleichzeitig einer (wachsenden) Heterogenität von Lerngruppen Rechnung getragen werden kann. Die vierzehn Beiträge sind in sechs Sektionen untergliedert: Sprachbildung; Sprachliche Vielfalt; Mehrsprachigkeit und Interkulturalität; Rezeption von Literatur, Kultur und Medialität; Literatur, Religion und Musik in heterogenen Lerngruppen; Digitalität, Digitalisierung und digitaler Wandel. Die Themenfelder werden im Dialog zwischen Neu- und Altphilologien (v.a. Anglistik und Latein, aber auch Romanistik) sowie der Musikpädagogik behandelt.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
Expression and Characterization of the Naturally Occurring Mutation L394R in Human γ-Glutamyl Carboxylase
Creators: name: Azerad, R.
name: Solera, J.
name: Stafford, D. W.
name: Mutucumarana, V. P.
name: Jin, D. Y.
name: Wu, S. M.
name: Brenner, B.
name: Stanley, T. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Patients with mutation L394R in gamma-glutamyl carboxylase have a severe bleeding disorder because of decreased biological activities of all vitamin K-dependent coagulation proteins. Vitamin K administration partially corrects this deficiency. To characterize L394R, we purified recombinant mutant L394R and wild-type carboxylase expressed in baculovirus-infected insect cells. By kinetic studies, we analyzed the catalytic activity of mutant L394R and its binding to factor IX's propeptide and vitamin KH(2). Mutant L394R differs from its wild-type counterpart as follows: 1) 110-fold higher K(i) for Boc-mEEV, an active site-specific, competitive inhibitor of FLEEL; 2) 30-fold lower V(max)/K(m) toward the substrate FLEEL in the presence of the propeptide; 3) severely reduced activity toward FLEEL carboxylation in the absence of the propeptide; 4) 7-fold decreased affinity for the propeptide; 5) 9-fold higher K(m) for FIXproGla, a substrate containing the propeptide and the Gla domain of human factor IX; and 6) 5-fold higher K(m) for vitamin KH(2). The primary defect in mutant L394R appears to be in its glutamate-binding site. To a lesser degree, the propeptide and KH(2) binding properties are altered in the L394R mutant. Compared with its wild-type counterpart, the L394R mutant shows an augmented activation of FLEEL carboxylation by the propeptide.
Robust dynamic mitigation of instabilities
Creators: name: Kawata, S.
name: Karino, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: A dynamic mitigation mechanism for instability growth was proposed and discussed in the paper [Phys. Plasmas 19, 024503 (2012)]. In the present paper the robustness of the dynamic instability mitigation mechanism is discussed further. The results presented here show that the mechanism of the dynamic instability mitigation is rather robust against changes in the phase, the amplitude and the wavelength of the wobbling perturbation applied. Generally instability would emerge from the perturbation of the physical quantity. Normally the perturbation phase is unknown so that the instability growth rate is discussed. However, if the perturbation phase is known, the instability growth can be controlled by a superposition of perturbations imposed actively: if the perturbation is induced by, for example, a driving beam axis oscillation or wobbling, the perturbation phase could be controlled and the instability growth is mitigated by the superposition of the growing perturbations.
description: 12 pages; 3 figures. Submitted to Phys. of Plasmas
(1904) Thomas Marshall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1905) ? Walker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mangrove deforestation and degradation areas in Indonesia 2009-2019
Creators: name: Arifanti, Virni
name: Kauffman, J. Boone
name: Subarno, Subarno
name: Ilman, Muhammad
name: Tosiani, Anna
name: Novita, Nisa
Publisher: name: Zenodo
Year: 2022

description: Mangrove forests are important carbon sinks and this is especially true for Indonesia where about 24% of the world's mangroves exist. Unfortunately, vast expanses of these mangroves have been deforested, degraded or converted to other uses resulting in significant greenhouse gas emissions. The objective of this study was to quantify the climate change mitigation potential of mangrove conservation and restoration in Indonesia. We calculated the emission factors from the dominant land uses in mangroves, determined mangrove deforestation rates and quantified the total emissions and the potential emission reductions that could be achieved from mangrove conservation and restoration. Based upon our analysis of the carbon stocks and emissions from land use in mangroves we found: (1) Indonesia's mangrove ecosystem carbon stocks are amongst the highest of any tropical forest type; (2) mangrove deforestation results in greenhouse gas emissions that far exceed that of upland tropical deforestation; (3) in the last decade the rates of deforestation in Indonesian mangroves have remained high; and (4) conservation and restoration of mangroves promise to sequester significant quantities of carbon. While mangroves comprise only ≈2.6% of Indonesia's total forest area, their degradation and deforestation accounted for ≈10% of total greenhouse gas emissions arising from the forestry sector. The large source of greenhouse gas emissions from a relatively small proportion of the forest area underscores the value for inclusion of mangroves as a natural climate solution (NCS). Mangrove conservation is far more effective than mangrove restoration in carbon emissions reductions and an efficient pathway to achieve Indonesia's nationally determined contribution (NDC) targets. The potential emission reduction from halting deforestation of primary and secondary mangroves coupled with restoration activities could result in an emission reduction equivalent to 8% of Indonesia's 2030 NDC emission reduction targets from the forestry sector.
description: Funding provided by: NORAD
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100007843
Award Number: GLO-4251 QZA-16/0172Funding provided by: Bezos Earth Fund*
Crossref Funder Registry ID:
Award Number: TCC-YKAN-BEFNCS-032021
(1901) Eliza Batty Hoyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Semi-quantitative analysis for target ZnFe2O4 from Microstructure, local electronic structure and optical behaviour of zinc ferrite thin films on glass substrate
Creators: name: Jitendra Pal Singh
name: Byeong-Hyeon Lee
name: Lim, Weon Cheol
name: Cheol-Hwee Shim
name: Jihye Lee
name: Chae, Keun Hwa
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: 30606 Structural Chemistry and Spectroscopy
subject: 30699 Physical Chemistry not elsewhere classified

description: JPS-Table S1
Expression and Function of Calcium Binding Domain Chimeras of the Integrins α IIb and α 5
Creators: name: Lyman, Suzanne
name: White II, Gilbert C.
name: Gidwitz, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: To further identify amino acid domains involved in the ligand binding specificity of alpha(IIb)beta(3), chimeras of the conserved calcium binding domains of alpha(IIb) and the alpha subunit of the fibronectin receptor alpha(5)beta(1) were constructed. Chimeras that replaced all four calcium binding domains, replaced all but the second calcium binding domain of alpha(IIb) with those of alpha(5), or deleted all four calcium binding domains were synthesized but not expressed on the cell surface. Additional chimeras exchanged subsets or all of the variant amino acids in the second calcium binding domain, a region implicated in ligand binding. Cell surface expression of each second calcium binding domain mutant complexed with beta(3) was observed. Each second calcium binding domain mutant was able to 1) bind to immobilized fibrinogen, 2) form fibrinogen-dependent aggregates after treatment with dithiothreitol, and 3) bind the activation-dependent antibody PAC1 after LIBS 6 treatment. Soluble fibrinogen binding studies suggested that there were only small changes in either the K(d) or B(max) of any mutant. We conclude that chimeras of alpha(IIb) containing the second calcium binding domain sequences of alpha(5) are capable of complexing with beta(3), that the complexes are expressed on the cell surface, and that mutant complexes are capable of binding both immobilized and soluble fibrinogen, suggesting that the second calcium binding domain does not determine ligand binding specificity.
Literalitäten im altsprachlichen Unterricht
Creators: name: Maas, Sophie K.
name: Korn, Matthias
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: Auf der Grundlage der Lehrpläne der Länder ist die Arbeit mit Rezeptionsdokumenten aus Spätantike, Mittelalter und Neuzeit konstitutiver Bestandteil von altsprachlichem Unterricht. Die unterrichtliche Praxis degradiert jedoch die Dokumente, in denen Stoffe und Motive der Antike rezipiert werden, oftmals zu reinen Materiallieferanten, weil deren Medienspezifik nur ungenügend berücksichtigt wird. Deren Berücksichtigung erfordert vor allem die Würdigung ihrer Funktionalität in ihrem kulturgeschichtlichen Kontext. Der Beitrag zeigt anhand von drei Beispielen unterschiedlicher Medialität, wie Literalitäten im altsprachlichen Unterricht hinsichtlich der Ansprüche, welche etwa die New London Group für den Umgang mit Multiliteracies fordert, angemessen berücksichtigt werden können. Als Beispiele werden herangezogen: Skulpturenensemble, Theaterstück und Bild.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
F XX LF and W XX LF Sequences Mediate the NH 2 -terminal Interaction with the Ligand Binding Domain of the Androgen Receptor
Creators: name: He, Bin
name: Wilson, Elizabeth M.
name: Kemppainen, Jon A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The nuclear receptor superfamily members of eukaryotic transcriptional regulators contain a highly conserved activation function 2 (AF2) in the hormone binding carboxyl-terminal domain and, for some, an additional activation function 1 in the NH(2)-terminal region which is not conserved. Recent biochemical and crystallographic studies revealed the molecular basis of AF2 is hormone-dependent recruitment of LXXLL motif-containing coactivators, including the p160 family, to a hydrophobic cleft in the ligand binding domain. Our previous studies demonstrated that AF2 in the androgen receptor (AR) binds only weakly to LXXLL motif-containing coactivators and instead mediates an androgen-dependent interaction with the AR NH(2)-terminal domain required for its physiological function. Here we demonstrate in a mammalian two-hybrid assay, glutathione S-transferase fusion protein binding studies, and functional assays that two predicted alpha-helical regions that are similar, but functionally distinct from the p160 coactivator interaction sequence, mediate the androgen-dependent, NH(2)- and carboxyl-terminal interaction. FXXLF in the AR NH(2)-terminal domain with the sequence (23)FQNLF(27) mediates interaction with AF2 and is the predominant androgen-dependent interaction site. This FXXLF sequence and a second NH(2)-terminal WXXLF sequence (433)WHTLF(437) interact with different regions of the ligand binding domain to stabilize the hormone-receptor complex and may compete with AF2 recruitment of LXXLL motif-containing coactivators. The results suggest a unique mechanism for AR-mediated transcriptional activation.
title: Effect of Bone Morphogenetic Protein-2 in the Treatment of Long Bone Non-Unions
Creators: name: Fuchs, Thomas
name: Stolberg-Stolberg, Josef
name: Michel, Philipp
name: Patric, Garcia
name: Amler, Susanne
name: Wähnert, Dirk
name: Raschke, Michael J.
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 610 Medicine and health

description: Background: Delayed fracture healing continues to cause significant patient morbidity and an economic burden to society. Biological stimulation of non-unions includes application of recombinant bone morphogenetic protein-2 (rhBMP-2). However, rhBMP-2 use continues to be a matter of controversy as literature shows scarce evidence for treatment effectiveness. Questions: The objective of this study was to evaluate the effectiveness of rhBMP-2 treatment on long bone non-unions measuring union rate and time to union. Furthermore, we assess risk factors for treatment failure. Methods and patients: A total of 91 patients with non-unions of long bones were treated with rhBMP-2 (n = 72) or standard care without BMP (n = 19) at our institution. Patient characteristics, comorbidities, nicotine consumption, and complications were recorded. Bone healing was assessed by plane X-rays and clinical examination. Patients were followed up with for 24 months. Results: Overall, there was significantly faster bone healing after rhBMP-2 application compared to the no-BMP group (p < 0.001; HR = 2.78; 95% CI 1.4–5.6). Union rates differed significantly between rhBMP-2 compared to the no-BMP group (89% vs. 47%; p < 0.001). At the humerus, there was neither a significantly higher union rate in the rhBMP-2 (83%) compared to the no-BMP group (50%) (p = 0.26; n = 12) nor a faster bone healing with a median time of 9 months in both groups (HR = 2.01; 95% CI 0.49–8.61; p = 0.315). The 33 femora treated using rhBMP-2 healed significantly faster than 9 femora in the no-BMP group (HR = 2.93; 95% CI 1.00–8.4; p = 0.023) with significant differences in union rate with 85% and 44%, respectively (p = 0.022). Regarding tibia non-unions, 25 out of 27 (93%) healed with a median of 9 months after rhBMP-2 application with no significant difference in the no-BMP group (33%) in time to union (p = 0.097) but a significantly higher union rate (p = 0.039). There was no effect of comorbidities, age, sex, soft tissue damage, or nicotine use on time to union, union rate, or secondary interventions. Conclusion: Consistent with the literature, overall, significantly higher union rates with reduced time to union were achieved after rhBMP-2 application. Femoral and tibial non-unions in particular seem to profit from rhBMP-2 application.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Hepatocytes Sensitized to Tumor Necrosis Factor-α Cytotoxicity Undergo Apoptosis through Caspase-dependent and Caspase-independent Pathways
Creators: name: Czaja, Mark J.
name: Srinivasan, Anu
name: Lo, Chau R.
name: Liu, Hailing
name: Valentino, Karen L.
name: Streetz, Konrad
name: Jones, Brett E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Hepatocytes can be sensitized to tumor necrosis factor (TNF)-alpha toxicity by repression of NF-kappaB activation or inhibition of RNA synthesis. To determine whether both forms of sensitization lead to TNF-alpha cytotoxicity by similar mechanisms, TNF-alpha-induced cell death in RALA255-10G hepatocytes was examined following infection with an adenovirus, Ad5IkappaB, that blocks NF-kappaB activation or following cotreatment with actinomycin D (ActD). TNF-alpha treatment of Ad5IkappaB-infected cells resulted in 44% cell death within 6 h. ActD/TNF-alpha induced no death within 6 h but did lead to 37% cell death by 24 h. In both instances, cell death occurred by apoptosis and was associated with caspase activation, although caspase activation in ActD-sensitized cells was delayed. CrmA and chemical caspase inhibitors blocked Ad5IkappaB/TNF-alpha-induced cell death but did not inhibit ActD/TNF-alpha-induced apoptosis. A Fas-associated protein with death domain (FADD) dominant negative decreased Ad5IkappaB/TNF-alpha- and ActD/TNF-alpha-induced cell death by 81 and 47%, respectively. However, downstream events differed, since Ad5IkappaB/TNF-alpha but not ActD/TNF-alpha treatment caused mitochondrial cytochrome c release. These results suggest that NF-kappaB inactivation and inhibition of RNA synthesis sensitize RALA255-10G hepatocytes to TNF-alpha toxicity through distinct cell death pathways that diverge below the level of FADD. ActD-induced hepatocyte sensitization to TNF-alpha cytotoxicity occurs through a FADD-dependent, caspase-independent pathway of apoptosis.
Non-Abelian dark matter and dark radiation
Creators: name: Buen-Abad, Manuel A.
name: Marques-Tavares, Gustavo
name: Schmaltz, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We propose a new class of dark matter models with unusual phenomenology. What is ordinary about our models is that dark matter particles are WIMPs, they are weakly coupled to the Standard Model and have weak scale masses. What is unusual is that they come in multiplets of a new "dark" non-Abelian gauge group with milli-weak coupling. The massless dark gluons of this dark gauge group contribute to the energy density of the universe as a form of weakly self-interacting dark radiation. In this paper we explore the consequences of having i.) dark matter in multiplets ii.) self-interacting dark radiation and iii.) dark matter which is weakly coupled to dark radiation. We find that i.) dark matter cross sections are modified by multiplicity factors which have significant consequences for collider searches and indirect detection, ii.) dark gluons have thermal abundances which affect the CMB as dark radiation. Unlike additional massless neutrino species the dark gluons are interacting and have vanishing viscosity and iii.) the coupling of dark radiation to dark matter represents a new mechanism for damping the large scale structure power spectrum. A combination of additional radiation and slightly damped structure is interesting because it can remove tensions between global $Λ$CDM fits from the CMB and direct measurements of the Hubble expansion rate ($H_0$) and large scale structure ($σ_8$).
description: 25 pages, 8 figures; v2: minor improvements, references added; v3: added references and an acknowledgement note to J. Lesgourgues; accepted for publication in PRD
Realization of face-shear piezoelectric coefficient d36 in PZT ceramics via ferroelastic domain engineering
Creators: name: Miao, Hongchen
name: Li, Faxin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The piezoelectric face-shear (d36) mode may be the most useful shear mode in piezoelectrics, while currently this mode can only exist in single crystals of specific point groups and cut directions. Theoretically the d36 coefficient vanishes in piezoelectric ceramics because of its transversally isotropic symmetry . In this work, we modified the symmetry of poled PZT ceramics from transversally isotropic to orthogonal through ferroelastic domain switching by applying a high lateral stress along the "2" direction and holding the stress for several hours. After removing the compression, the piezoelectric coefficient d31 is found much larger than d32. Then by cutting the compressed sample along the zxt+45 deg direction, we realized d36 coefficients up to 206 pC/N which is measured by using a modified d33 meter. The obtained large d36 coefficients in PZT ceramics could be very promising for face-shear mode resonators and shear horizontal (SH) wave generation in nondestructive testing.
description: 12 pages, 5 figures
Supplemental legends and tables from Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Creators: name: Raich, Natacha
name: Souhir Mahmoudi
name: Emre, Doruk
name: Karess, Roger E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences

description: Additional controls and data corresponding to Figs 1-4.
Supplemental Figures from Mad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Creators: name: Raich, Natacha
name: Souhir Mahmoudi
name: Emre, Doruk
name: Karess, Roger E.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences

description: Figs 1-4.
Die Entdeckung neuer Bilder - Zur ekstatischen Wahrheit in Werner Herzogs Dokumentarfilmen
Creators: name: Eising, Sabine
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Dokumentarfilm, ekstatische Wahrheit, Stilanalyse, Werner Herzog
subject: 791 Öffentliche Darbietungen, Film, Rundfunk

description: Mit seinen dokumentarischen Werken trug der deutsche Filmemacher Werner Herzog zu einer Neukonzeption der Gattung bei. Herzog wehrt sich gegen Fernseh- und Konsumbilder und möchte unverbrauchte und verborgene Bilder entdecken. Die Produktion solcher Bilder beschreibt er als eine existenzielle Notwendigkeit für das Überleben der Gesellschaft. Dabei ist er stets auf der Suche nach dem Wesen der Menschen und nach einer tieferen, zunächst nicht sichtbaren, ekstatischen Wahrheit. Herzog ist fasziniert von extremen Lebenssituationen und existenziellen Außenseitern, deren Geschichten er erzählt. Durch eine experimentelle Bildsprache, die besondere Form der filmischen Präsentation sowie aufwendige Inszenierungen verfolgt der Filmemacher eine ganz eigene Erzählstrategie. Anhand des Dokumentarfilms Land des Schweigens und der Dunkelheit (1971) wird untersucht, worin sich der besondere filmische Stil Herzogs in seinen Werken manifestiert.
Antinomies of Inter- and Transcultural Learning
Creators: name: Volkmann, Laurenz
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2020

description: It is a difficult and certainly troubling insight that some of the goals or competences under discussion in the context of inter- and transcultural learning can and must be seen as having little in common. They can even be considered as conflicting, contradictory or mutually exclusive – one may only reflect on the discrepant expectations connected with the goal of “critical thinking” (with regard to other cultures) on the one hand and the idea of “emphatic understanding” (of other cultures) on the other (cf. Breithaupt 2017). Such jarring of oppositional phenomena in educational contexts can be explored with reference to Helsper’s discussion of how any kind of teaching or learning in today’s modern, differentiated society takes place within a matrix of oppositional concepts and objectives (cf. Helsper 2002, 2010, Schlömerkemper 2017). Specifically, Helsper uses the term “antinomies” to indicate that pedagogic practice always entails a choice between different options, each “hailing,” so to speak, to be given prominence and each encompassing a different range of specific teaching and learning goals, strategies, techniques and practical steps. This article will apply the concept of pedagogic antinomies to current challenges in the fields of inter- and transcultural teaching/learning.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Vol 2 No 4 (2020): Standards – Margins – New Horizons. Teaching Language and Literature in the 21st Century
American Exceptionalism in Death Stranding: Videogames and Culture
Creators: name: Kurasov, Anja
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: videogames; media analysis; Death Stranding; American exceptionalism; ideology
subject: 793 Spiel

description: With videogames being one of the most popular and widespread forms of entertainment media to date, this essay wishes to regard the medium as a cultural artifact that both shapes and continuously is shaped by culture. For this purpose, this essay analyzes the 2019 videogame Death Stranding, delving into the game’s central theme of reconnecting a post-apocalyptic United States during a time of deep division, tying this to a criticism of the ideology of American exceptionalism. Through analysis of both the game’s narrative elements and the ways in which the game is played, this paper makes evident how Death Stranding deconstructs American exceptionalist narratives with the intention of laying bare foundational issues within American society, problems that all stem from the same narratives that so deeply define the Unitet States' national identity.
Topological phases of an interacting Majorana Benalcazar-Bernevig-Hughes model
Creators: name: Maiellaro, Alfonso
name: Illuminati, Fabrizio
name: Citro, Roberta
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the effects of Coulomb repulsive interactions on a Majorana Benalcazar-Bernevig-Hughes (MBBH) model. The MBBH model belongs to the class of second--order topological superconductors ($HOTSC_2$), featuring robust Majorana corner modes. We consider an interacting strip of four chains of length $L$ and perform a DMRG numerical analysis based on a tensor--network approach. Study of the nonlocal fermionic correlations and of the degenerate entanglement spectrum indicates that the topological phases are robust in the presence of interactions, even in the strongly interacting regime.
description: 10 pages, 5 figures
(1898) Mary [Pickard]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.