cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(401031) John Home Shiell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
Creators: name: Whang, Y. E.
name: Zhang, Z.
name: Karaca, M.
name: Gioeli, D.
name: Liu, Y.
name: Earp, H. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Activation of androgen receptor (AR) may play a role in the development of castration resistant prostate cancer. Two intracellular tyrosine kinases, Ack1 (activated cdc42-associated kinase) and Src, phosphorylate and enhance AR activity and promote prostate xenograft tumor growth in castrated animals. However, the upstream signals that activate these kinases and lead to AR activation are incompletely characterized. In this study, we investigated AR phosphorylation in response to non-androgen ligand stimulation using phospho-specific antibodies. Treatment of LNCaP and LAPC-4 cells with epidermal growth factor (EGF), heregulin, Gas6 (ligand binding to Mer receptor tyrosine kinase and activating Ack1 downstream), interleukin (IL)-6 or bombesin stimulated cell proliferation in the absence of androgen. Treatment of LNCaP and LAPC-4 cells with EGF, heregulin, or Gas6 induced AR phosphorylation at Tyr-267; IL-6 or bombesin treatment did not. AR phosphorylation at Tyr-534 was induced by treatment with EGF, IL-6 or bombesin, but not by heregulin or Gas6. siRNA-mediated knockdown of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6-induced AR Tyr-267 phosphorylation whereas Src mediates Tyr-534 phosphorylation induced by EGF, IL-6, and bombesin. Dasatinib, a Src inhibitor, blocked EGF-induced Tyr-534 phosphorylation. In addition, we show dasatinib also inhibited Ack1 kinase. Dasatinib inhibited heregulin-induced Ack1 kinase activity and AR Tyr-267 phosphorylation. Dasatinib inhibited heregulin-induced AR-dependent reporter activity. Dasatinib also inhibited heregulin-induced expression of endogenous AR target genes. Dasatinib inhibited Ack1-dependent colony formation and prostate xenograft tumor growth in castrated mice. Interestingly, Ack1 or Src knockdown or dasatinib did not inhibit EGF-induced AR Tyr-267 phosphorylation or EGF-stimulated AR activity, suggesting the existence of an additional tyrosine kinase that phosphorylates AR at Tyr-267. These data suggest that specific tyrosine kinases phosphorylate AR at distinct sites and that dasatinib may exert anti-tumor activity in prostate cancer through inhibition of Ack1.
The Cirripedia associated with Loggerhead Sea Turtles, Caretta caretta, in the Gulf of Gabès, Tunisia
Creators: name: KARAA, Sami
name: JRIBI, Imed
name: BOUAIN, Abderrahmen
name: BRADAI, Mohamed Nejmeddine
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The barnacles associated with loggerhead sea turtles from the Gulf of Gabès are reported. Eleven species were identified from four families: Chelonibiidae (3 species), Lepadidae (2 species), Platylepadidae (3 species) and Balanidae (3 species). The chelonophilic barnacle Stephanolepas muricata is recorded for the first time from the south and central Mediterranean Sea. The preferential distribution of epibiotic Cirripedia is discussed.
Supplementary Information from Diurnal variation in the production of vocal information about food supports a model of social adjustment in wild songbirds
Creators: name: F. Hillemann
name: E. F. Cole
name: S. C. Keen
name: B. C. Sheldon
name: D. R. Farine
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Diurnal variation in the production of vocal information about food supports a model of social adjustment in wild songbirds
(401030) Ann Dooley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
Creators: name: Der, C. J.
name: Hanker, A. B.
name: Mitin, N.
name: Wilder, R. S.
name: Cox, A. D.
name: Henske, E. P.
name: Tamanoi, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C = cysteine, A = aliphatic, X = terminal amino acid) motif, a substrate for posttranslational modification by a farnesyl isoprenoid. Following farnesylation, Rheb undergoes two additional CAAX-signaled processing steps, Rce1-catalyzed cleavage of the AAX residues and Icmt-mediated carboxylmethylation of the farnesylated cysteine. However, whether these post-prenylation processing steps are required for Rheb signaling through mTOR is not known. We found that Rheb1 and Rheb2 localize primarily to the endoplasmic reticulum and Golgi apparatus. We determined that Icmt and Rce1 processing is required for Rheb localization, but is dispensable for Rheb-induced activation of the mTOR substrate p70 S6 kinase (S6K). Finally, we evaluated whether farnesylthiosalicylic acid (FTS) blocks Rheb localization and function. Surprisingly, FTS prevented S6K activation induced by a constitutively active mTOR mutant, indicating that FTS inhibits mTOR at a level downstream of Rheb. We conclude that inhibitors of Icmt and Rce1 will not block Rheb function, but FTS could be a promising treatment for Rheb- and mTOR-dependent cancers.
Bryozoan biodiversity in Saint Peter and Saint Paul Archipelago, Brazil
Creators: name: VIEIRA, Leandro M.
name: FARRAPEIRA, Cristiane M.R.
name: AMARAL, Fernanda D.
name: LIRA, Simone M.A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Among the marine invertebrate groups recorded from oceanic islands, bryozoans stand out because they can live and reproduce in suboptimal habitats, which may enhance their dispersal capabilities. This study aimed to update the check- list of bryozoans known from the Saint Peter and Saint Paul Archipelago (ASPSP) and discusses their distribution. During the five expeditions conducted between 2007 and 2009, 22 species were found, of which 16 were new occurrences for the archipelago. The bryozoans were collected from different biotic (algae and invertebrates) and abiotic (rocks, rubble and wrecks) substrata. The bryozoan community in ASPSP includes: eight new and probably endemic species, five species that belong to widespread species complexes, three species known only from the Brazilian coast, two species reported from the Western Atlantic and one species recorded from oceanic islets in the Atlantic. Additionally, three species are widespread in tropical to subtropical waters. Margaretta buski can be highlighted as the most conspicuous and abundant species between 10- 45 m deep and acts as an "ecosystem engineer".
Numerical results for gauge theories near the conformal window
Creators: name: Lucini, Biagio
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A novel strong interaction beyond the standard model could provide a dynamical explanation of electroweak symmetry breaking. Experimental results strongly constrain properties of models that realise this mechanism. Whether these constraints are obeyed by any strongly interacting quantum field theory is a non-perturbative problem that needs to be addressed by first-principle calculations. Monte Carlo simulations of lattice regularised gauge theories is a powerful tool that enables us to address this question. Recently various lattice investigations have appeared that have studied candidate models of strongly interacting dynamics beyond the standard model. After a brief review of the main methods and of some recent results, we focus on the analysis of SU(2) gauge theory with one adjoint Dirac fermion flavour, which is shown to have a near-conformal behaviour with an anomalous dimension of order one. The implications of our findings are also discussed.
(401029) William Crichton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Comparative study of haematological profile on Gobius niger in two different habitat sites: Faro Lake and Tyrrhenian Sea
Creators: name: FAZIO, Francesco
name: FAGGIO, Caterina
name: MARAFIOTI, Simona
name: TORRE, Agata
name: SANFILIPPO, Marilena
name: PICCIONE, Giuseppe
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The present study is aimed to assess the influence of different habitats, Faro Lake and Tyrrhenian Sea, on the haematological profile of Gobius niger. For both sites of collection water chemical-physical parameters were measured. Blood samples were taken from 20 fish captured in Faro Lake (group A) and from 20 fish captured in Tyrrhenian Sea (group B) to measure haematological profile that included Red Blood Cell Count (RBC), Hematocrit (Hct), Hemoglobin concen- tration (Hgb), White Blood Cell Count (WBC), Thrombocyte Count (TC), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Red cell Distribution Width (RDW), Mean Thrombocyte Volume (MTV), Thrombocyte Distribution Width (TDW) and Thrombocytocrit (Tct). Results showed significantly statistical differences in RBC, Hct, MCH and MCHC between two different locations that are related to variations of the chemical and physical parameters of the water of two different sites of collection. Our findings emphasize the fact that changes in blood characteristics are important indices in monitoring the effects of habitat changes on the physiology of G. niger.
(401028) James O'Brian Saunders
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
“GMO” maize and public health – A case of Schumpeterian policy vs. free market in the EU
Creators: name: Tagliabue, Giovanni
Publisher: name: Bio-based and Applied Economics
Year: 2017

description: EU lawmakers have long refused the cultivation of “Genetically Modified Organisms”. An example of this struggle is the revision of the accepted level of contaminants in maize: rather than admitting that Bt maize is safer than “non-GMO” varieties, and therefore European farmers should be allowed not only to import it, but also to produce it, politicians have raised the threshold of the poisonous fumonisins that may be legally present in food and feed. This decision is an example of a “Schumpeterian” approach to policy, where public choices are not inspired by a science-based mindset, but are substantially dictated by a calculus of consent; economic/commercial protectionism has also been considered as a motivation. While scholars must continue to explain that every policy decision should have a basis in sound science, no way out of the “GMO” imbroglio seems to be foreseeable, as long as politicians stick to the Schumpeterian iron law.
description: Bio-based and Applied Economics, Vol 5 No 3 (2016)
Epstein-Barr virus latent membrane protein-2A-induced ΔNp63α expression is associated with impaired epithelial-cell differentiation
Creators: name: Raab-Traub, N.
name: Fotheringham, J. A.
name: Mazzucca, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Epstein-Barr virus (EBV) is an oncogenic γ-herpes virus associated with malignancies that develop in both lymphoid and epithelial cells including nasopharyngeal carcinoma (NPC). The EBV protein latent membrane protein 2A (LMP2A) is expressed in NPC and can modulate epithelial proliferation, transformation, and differentiation, and as such, may promote malignancy. A key regulator of epithelial cell differentiation is the transcription factor p63, a member of the p53 family. This study examines the potential contribution of p63 to LMP2A-mediated inhibition of epithelial differentiation. Stable expression of LMP2A increased the protein level and stability of the ΔNp63α isoform, and in two epithelial cell lines, LMP2A interacted with ΔNp63α under stable and transient expression systems. LMP2A and ΔNp63α were localized to the cytoplasm and nuclear membrane and co-immunoprecipitated in the same fractions. Following induction of epithelial cell differentiation by calcium, expression of differentiation markers was impaired in both ΔNp63α and LMP2 expressing cells. Induction of p63α, association of p63α with LMP2A, and impairment of differentiation required the PY and ITAM signaling motif of LMP2A. By associating with and being regulated by LMP2A,ΔNp63α may function as a unique regulator of LMP2A effects on epithelial differentiation and contribute to EBV-associated epithelial cancers.
title: Cyclopent[cd]azulene and 1,2-Dihydrodicyclopent-[cd,ij]azulene
Creators: name: Hafner, Klaus
name: Meinhardt, Klaus-Peter
name: Richarz, Winfried
Publisher: name: Wiley
Year: 2023

description: Alkyl and aryl derivatives [¹] of cyclopent[cd]azulene (1) exhibit a notable reactivity in cycloaddition reactions with alkenes, alkynes, and carbenes[²].
Her2 activates NF-κB and induces invasion through the canonical pathway involving IKKα
Creators: name: Baldwin, A. S.
name: Cogswell, P.
name: Merkhofer, E. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The membrane bound receptor tyrosine kinase Her2 is overexpressed in approximately 30% of human breast cancers which correlates with poor prognosis. Her2-induced signaling pathways include MAPK and PI3K/Akt, of which the latter has been shown to be critical for Her2+ breast cancer cell growth and survival. Additionally, the NF-κB pathway has been shown to be activated downstream of Her2 overexpression, however the mechanisms leading to this activation are not currently clear. Using Her2+/ER- breast cancer cells, we show that Her2 activates NF-κB through the canonical pathway which, surprisingly, involves IKKα. Knockdown of IKKα led to a significant decrease in transcription levels of multiple NF-κB-regulated cytokine and chemokine genes. siRNA-mediated knockdown of IKKα resulted in a decrease in cancer cell invasion, but had no effect on cell proliferation. Inhibition of the PI3K/Akt pathway had no effect on NF-κB activation, but significantly inhibited cell proliferation. Our study suggests different roles for the NF-κB and PI3K pathways downstream of Her2, leading to changes in invasion and proliferation of breast cancer cells. Additionally this work indicates the importance of IKKα as a mediator of Her2-induced tumor progression.
(401027) Ann Crichton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401026) Allan Stewart Saunders
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Magnetic Refrigeration with Recycled Permanent Magnets and Free Rare-Earth Magnetocaloric La–Fe–Si
Creators: name: Benke, Dimitri
name: Fries, Maximilian
name: Specht, Marius
name: Wortmann, Jonas
name: Pabst, Marc
name: Gottschall, Tino
name: Radulov, Iliya
name: Skokov, Konstantin
name: Bevan, Alex Ivor
name: Prosperi, Davide
name: Tudor, Catalina
name: Afiuny, Peter
name: Zakotnik, Miha
name: Gutfleisch, Oliver
Publisher: name: UNSPECIFIED
Year: 2020

description: Magnetic refrigeration is an upcoming technology that could be an alternative to the more than 100-year-old conventional gas–vapor compression cooling. Magnetic refrigeration might answer some of the global challenges linked with the increasing demands for readily available cooling in almost every region of the world and the global-warming potential of conventional refrigerants. Important issues to be solved are, for example, the required mass and the ecological footprint of the rare-earth permanent magnets and the magnetocaloric material, which are key parts of the magnetic cooling device. The majority of existing demonstrators use Nd–Fe–B permanent magnets, which account for more than 50% of the ecological footprint, and Gd, which is a critical raw material. This work shows a solution to these problems by demonstrating the world’s first magnetocaloric demonstrator that uses recycled Nd–Fe–B magnets as the magnetic field source, and, as a Gd replacement material, La–Fe–Mn–Si for the magnetocaloric heat exchanger. These solutions show that it is possible to reduce the ecological footprint of magnetic cooling devices and provides magnetic cooling as a green solid-state technology that has the potential to satisfy the rapidly growing global demands.
(401025) Alice McGlashan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1
Creators: name: Damania, B.
name: Wen, K. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Kaposi sarcoma-associated herpesvirus (KSHV) is a member of the gammaherpesvirus family. It is the etiological agent of three different human cancers, Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). The far left-end of the KSHV genome encodes a unique transmembrane glycoprotein called K1. K1 possesses the ability to transform rodent fibroblasts and block apoptosis. K1 has also been shown to activate the PI3K/Akt/mTOR pathway in different cellsUsing tandem affinity purification (TAP), we identified heat shock protein 90β (Hsp90β) and endoplasmic reticulum (ER)-associated Hsp40 (Erdj3/DnaJB11), as cellular binding partners of K1. Interactions of K1 with Hsp90β and Hsp40 were confirmed by co-immunoprecipitation in both directions. Furthermore, K1 also interacted with the Hsp90α̣ isoform. We report that siRNAs directed against Hsp90 and Hsp40/Erdj3, as well as pharmacological inhibitors of Hsp90 dramatically reduced K1 expression, suggesting that K1 is a client protein of these chaperones. Additionally, both Hsp90 and Hsp40/Erdj3 were essential for K1’s anti-apoptotic function. Finally, we report that the Hsp90 inhibitors, 17-AAG and 17-DMAG, can suppress the proliferation of KSHV-positive PEL cell lines and exhibited IC50 values of 50nM and below.
Health status of the date mussel Lithophaga lithophaga (Linné, 1758) from the North of Tunisia
Creators: name: JAAFAR KEFI, Ferdaous
name: GARGOURI BEN ABDALLAH, Lamia
name: TRIGUI EL-MENIF, Najoua
name: MRAOUNA, Radhia
name: EL BOUR, Monia
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: The present study was done with a view to characterize the health status of the Tunisian date mussel Lithophaga lithophaga following the detection of shell disturbances on the external and internal side of the valves. Macroscopic and microscopic observations and bacteriological analysis were carried out seasonally from 2004 to 2006 on samples from Bizerte Bay (Northern Tunisia). Burrowing annelids and sipunculids living inside galleries on the internal valve surface have been removed. Shell thinness and galleries have led to serious morphological disturbances of the lithophagid bivalves. Besides, brown-blackish or white stains appeared on the external and/or inner surfaces of the valves with the periostracal layer missing. Shell ESEM (Environmental Scanning Electron Microscopy) examination showed the presence of thick mucilage on the external valve surfaces with the microscopic tubiculous annelids stuck to them. On the internal side, the shell was perforated by minute pores of 2 µm diameter. Otherwise, no parasites were specified on the date mussel flesh. Bacteriological analysis revealed important accumulation of heterotrophic mesophyllic bacteria particularly in summer and autumn (3.107 and 2.108 CFU ml-1 respectively). Pathogen Vibrionaceaes appeared in high concentration during the study. Three kinds of bacteria (Vibrio hollisae, Pasteurella pneumotropica and Chrysomonas luteola) are suspected of being the cause of stains in L. lithophaga.
Supplementary Material from Moralizing gods, impartiality and religious parochialism across 15 societies.
Creators: name: Lang, Martin
name: Purzycki, Benjamin G.
name: Coren L. Apicella
name: Atkinson, Quentin D.
name: Bolyanatz, Alexander
name: Cohen, Emma
name: Handley, Carla
name: Klocová, Eva Kundtová
name: Lesorogol, Carolyn
name: Mathew, Sarah
name: McNamara, Rita A.
name: Moya, Cristina
name: Placek, Caitlyn D.
name: Soler, Montserrat
name: Vardy, Thomas
name: Weigel, Jonathan L.
name: Willard, Aiyana K.
name: Xygalatas, Dimitris
name: Norenzayan, Ara
name: Henrich, Joseph
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Additional materials, methods, and results
Somatic p16INK4a loss accelerates melanomagenesis
Creators: name: Monahan, K. B.
name: Horner, J.
name: Liu, W.
name: Johnson, S. M.
name: Rozenberg, G. I.
name: Depinho, R. A.
name: Bradford, M. K.
name: Krishnamurthy, J.
name: Sharpless, N. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Loss of p16INK4a–RB and ARF–p53 tumor suppressor pathways, as well as activation of RAS–RAF signaling, is seen in a majority of human melanomas. Although heterozygous germline mutations of p16INK4a are associated with familial melanoma, most melanomas result from somatic genetic events: often p16INK4a loss and N-RAS or B-RAF mutational activation, with a minority possessing alternative genetic alterations such as activating mutations in K-RAS and/or p53 inactivation. To generate a murine model of melanoma featuring some of these somatic genetic events, we engineered a novel conditional p16INK4a-null allele and combined this allele with a melanocyte-specific, inducible CRE recombinase strain, a conditional p53-null allele and a loxP-stop-loxP activatable oncogenic K-Ras allele. We found potent synergy between melanocyte-specific activation of K-Ras and loss of p16INK4a and/or p53 in melanomagenesis. Mice harboring melanocyte-specific activated K-Ras and loss of p16INK4a and/or p53 developed invasive, unpigmented and nonmetastatic melanomas with short latency and high penetrance. In addition, the capacity of these somatic genetic events to rapidly induce melanomas in adult mice suggests that melanocytes remain susceptible to transformation throughout adulthood.
Impact of CGM on postoperative glucose control in liver transplant recipients with diabetes mellitus
Creators: name: Hagerf, Barbora
name: Protuš, Marek
name: Németová, Lenka
name: Mráz, Miloš
name: Haluzík, Martin
name: Girman, Peter
name: Kieslichová, Eva
name: Švirlochová, Veronika
name: Franeková, Janka
name: Jabor, Antonín
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Liver Transplantation
subject: Diabetes Mellitus
subject: glucose control

description: This study was supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (ProgrammeEXCELES, Project No. LX22NPO5104)—Funded by the EuropeanUnion—Next Generation EU.
Length-weight relationships of 15 lagoon fish species collected in the Beymelek Lagoon (SW Turkey)
Creators: name: SÜMER, Çetin
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Length-weight relationships were estimated for 15 fish species sampled with combined gillnet and trammel net and fishing traps between December 2004 and December 2005 in the Beymelek Lagoon, Turkey (Mediterranean Sea). The values of the slope b in the length-weight relationship ranged between 2.188 and 3.131, with a mean of 2.753 ± 0.077. While isometric growth (Pauly's t-test, P > 0.05) was observed for 9 species, negative allometic growth (Pauly's t-test, P < 0.05) was observed for 6 species.
Topoisomerase IIα maintains genomic stability through decatenation G2 checkpoint signaling
Creators: name: Kaufmann, W. K.
name: Simpson, D. A.
name: Karaca, G. F.
name: Zhou, Y.
name: Bower, J. J.
name: Cordeiro-Stone, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Topoisomerase IIα (topoIIα) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G2 checkpoint response, which delays mitotic entry due to insufficient decatenation of daughter chromatids. Here we examine the effects of both topoIIα and topoIIβ on decatenatory activity in cell extracts, DNA damage and decatenation G2 checkpoint function, and the frequencies of p16INK4A allele loss and gain. In diploid human fibroblast lines, depletion of topoIIα by siRNA was associated with severely reduced decatenatory activity, delayed progression from G2 into mitosis, and insensitivity to G2 arrest induced by the topoII catalytic inhibitor ICRF-193. Furthermore, interphase nuclei of topoIIα-depleted cells displayed increased frequencies of losses and gains of the tumor suppressor genetic locus p16INK4A. This study demonstrates that the topoIIα protein is required for decatenation G2 checkpoint function, and inactivation of decatenation and the decatenation G2 checkpoint leads to abnormal chromosome segregation and genomic instability.
(401024) George Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Age, growth, longevity, natural mortality and maturity of the longnose spurdog, Squalus blainvillei (Chondrichthyes: Squalidae), in the Gulf of Gabès (Central Mediterranean Sea)
Creators: name: MAROUANI, Sondes
name: KADRI, Hasna
name: SAIDI, Bechir
name: MORIZE, Eric
name: BOUAIN, Abderrahmen
name: BRADAI, Mohamed Nejmeddine
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Age, growth, longevity, natural mortality and size and age at maturity of the longnose spurdog, Squalus blainvillei, in the Gulf of Gabès (Tunisia, Central Mediterranean Sea) are reported. Marginal increment suggested annual band formation. Age estimates ranged from 3 to 15 and 4 to 19 years for males and females, respectively. Von Bertalanffy growth parameters derived from length at age data were: L∞ = 105.7 cm, K = 0.11year-1, t0 = −1.12 year for females and L∞ = 91.1 cm, K = 0.14 year-1, t0 = −1.42 year for males. Males and females reached maturity at 52.3 cm and 62.5 cm TL corresponding to 4.97 and 7.44 years, respectively. Longevity estimates were 24.75 and 31.50 years for males and females, respectively. Based on life history parameters, natural mortality estimation M ranged from 0.16 to 0.33.
TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity
Creators: name: Kwiatkowski, D. J.
name: Qin, W.
name: Liang, M. C.
name: Wong, K. K.
name: Kozlowski, P.
name: Meyerson, M.
name: Shimamura, T.
name: Chen, L.
name: Hayes, D. N.
name: Goto, J.
name: Ma, J.
name: Li, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Germline TSC1 or TSC2 mutations cause Tuberous Sclerosis Complex (TSC), a hamartoma syndrome with lung involvement. To explore the potential interaction between TSC1 and KRAS activation in lung cancer, mice were generated in which Tsc1 loss and KrasG12D expression occur in a small fraction of lung epithelial cells. Mice with combined Tsc1-KrasG12D mutation had dramatically reduced tumor latency (median survival 11.6 – 15.6 weeks) in comparison to KrasG12D alone mutant mice (median survival 27.5 weeks). Tsc1-Kras G12D tumors showed consistent activation of mTORC1, and responded to treatment with rapamycin leading to significantly improved survival, while rapamycin had minor effects on cancers in KrasG12D alone mice. Loss of heterozygosity for TSC1 or TSC2 was found in 22% of 86 human lung cancer specimens. However, none of 80 lung cancer lines studied showed evidence of lack of expression of either TSC1 or TSC2 or a signaling pattern corresponding to complete loss. These data indicate Tsc1 loss synergizes with Kras mutation to enhance lung tumorigenesis in the mouse, but that this is a rare event in human lung cancer. Rapamycin may have unique benefit for lung cancer patients in which TSC1/TSC2 function is limited.
IKK-dependent, NF-κB-independent control of autophagic gene expression
Creators: name: Comb, W. C.
name: Cogswell, P.
name: Sitcheran, R.
name: Baldwin, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The induction of mammalian autophagy, a cellular catabolic bulk-degradation process conserved from humans to yeast, was recently shown to require IKK, the upstream regulator of the NF-κB pathway. Interestingly, it was shown that this response did not involve classic NF-κB. Thus, the mechanism by which IKK promotes stimulus-induced autophagy is largely unknown. Here we investigate the role of IKK/NF-κB in response to nutrient deprivation, the classic autophagy-inducing stimulus. IKK and both the classic and non-canonical pathways of NF-κB are robustly induced in response to cellular starvation. Notably, cells lacking either catalytic subunit of IKK (IKKα or IKKβ) fail to induce autophagy in response to cellular starvation. Importantly, we show that IKK activity but not NF-κB, controls basal expression of the pro-autophagic gene LC3. We further demonstrate that starvation induces the expression of LC3 and two other essential autophagic genes, ATG5 and Beclin-1, in an IKK-dependent manner. These results demonstrate that the IKK complex is a central mediator of starvation-induced autophagy in mammalian cells and suggest that this requirement occurs at least in part through the regulation of autophagic gene expression. Interestingly, NF-κB subunits are dispensable for both basal and starvation-induced expression of pro-autophagic genes. However, starvation-induced activation of NF-κB is not inconsequential as increases in expression of anti-apoptotic NF-κB target genes such as cIAP2 is observed in response to cellular starvation. Thus, IKK likely plays multiple roles in response to starvation by regulating NF-κB-dependent anti-apoptotic gene expression as well as controlling expression of autophagic genes through a yet undetermined mechanism.
Seasonal variations of lipid and moisture content in relation to sexual cycle of round sardinella Sardinella aurita Valenciennes 1847 in the eastern middle Adriatic Sea
Creators: name: MUSTAĆ, Bosiljka
name: SINOVČIĆ, Gorenka
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: A total of 2,033 round sardinella specimens were analysed to examine their moisture and lipid content, condition and gonadosomatic index. Total length (TL) ranged between 10.0 and 32.5 cm (mean ± SD = 22.0 ± 3.65 cm). Lipid content started to increase in August, reaching its peak in October. Higher values continued during winter months and then declined in spring. GSI, condition and SST values indicated an inverse annual cycle in comparison to lipid content - increasing in spring and peaking during summer months. Mesenteric fat and lipid content showed similar annual pattern. The abundance of round sardinella has increased in the Adriatic Sea and Mediterranean, whereas Sardina pilchardus and Engraulis encrasicolus, economically important and abundant pelagic fish species, have been suffering marked declines in their populations. This directly affects the interspecies relations in the pelagic communities, as well as in the fish meal processing industries which have recently started to include round sardinella.
title: A rare case of dystrophic calcifications in the heart
Creators: name: Agarwal, Aniket
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Cardiovascular
subject: Cardiac
subject: CT
subject: MR
subject: MR-Functional imaging
subject: Clinical Cases

description: Clinical History: A 77-year-old male with history of hypertension and diabetes mellitus presented with complaints of easy fatiguability on taking a flight of few steps. Previously, he was detected with valvular heart disease before undergoing orthopedic surgery in 2018. The patient also had atrial fibrillation since 2019.  

description: 77 years, male
(401023) Alice M Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary Material from Moralizing gods, impartiality and religious parochialism across 15 societies
Creators: name: Lang, Martin
name: Purzycki, Benjamin G.
name: Coren L. Apicella
name: Atkinson, Quentin D.
name: Bolyanatz, Alexander
name: Cohen, Emma
name: Handley, Carla
name: Klocová, Eva Kundtová
name: Lesorogol, Carolyn
name: Mathew, Sarah
name: McNamara, Rita A.
name: Moya, Cristina
name: Placek, Caitlyn D.
name: Soler, Montserrat
name: Vardy, Thomas
name: Weigel, Jonathan L.
name: Willard, Aiyana K.
name: Xygalatas, Dimitris
name: Norenzayan, Ara
name: Henrich, Joseph
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Additional materials, methods, and results
Comment on "A three-loop radiative neutrino mass model with dark matter" [Phys. Lett. B 741 (2015) 163]
Creators: name: Geng, Chao-Qiang
name: Huang, Da
name: Tsai, Lu-Hsing
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We revisit the calculation of the three-loop diagrams for the radiative neutrino mass generation and consider some relevant constraints on the model recently proposed by L. Jin {\it et al} [Phys. Lett. B 741 (2015) 163]. We find that the previous approximation is inappropriate due to the neglect of some important contributions, and the benchmark point proposed can neither give rise to enough neutrino masses nor accommodate these additional constraints, such as the validity of the perturbation theory, the electroweak precision measurements, and the neutrinoless double beta decays.
description: 5 pages, 1 figure, accepted for publication in Phys. Lett. B
Age and growth of little tunny, Euthynnus alletteratus (Rafinesque, 1810), from the Tunisian Mediterranean coasts
Creators: name: HAJJEJ, Ghailen
name: HATTOUR, Abdallah
name: HAJJEJ, Abdelhafidh
name: CHERIF, Mourad
name: ALLAYA, Hassen
name: JARBOUI, Othman
name: BOUAIN, Abderrahmen
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2012

description: Fin spine ageing is the most common technique used to estimate age and growth parameters of large pelagic fishes including the family of Scombridae. Age and growth of little tunny were estimated from seasonally formed bands on the first dorsal spines of 413 specimens of Euthynnus alletteratus (19.2-97.8 cm FL) collected in Tunisian waters from January 2008 to December 2009. The maximum age estimated for both sexes was 7 years. The monthly percentage of specimens having a terminal translucent zone indicated that growth rings formed once a year, during the cold season (January). Age readings were very precise, with a percentage agreement of 96% between readers and low values of the index of average percent error (2.6%). Von Bertalanffy growth parameters were estimated for males, females, and both sexes combined. There was no significant difference between males and females (P > 0.05). The parameter estimates for the combined sexes were asymptotic length L∞ = 127.2 cm, growth coefficient K = 0.139 and age at zero length t0 = -2.14 years. Comparisons of growth curves did not indicate any significant differences in the rate of growth between sexes. The backcalculation method demonstrated the validity of using spine sections for estimating age and growth of little tunny.
Supplementary material from Microbial communities in hummingbird feeders are distinct from floral nectar and influenced by bird visitation.
Creators: name: Lee, Casie
name: Tell, Lisa
name: Hilfer, Tiffany
name: Vannette, Rachel L.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Supplementary methods, figures and tables
(401022) George [JNR] Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Synthese und Struktur der ersten [2₂]Metallocenophane
Creators: name: Hafner, Klaus
name: Mink, Carsten
name: Lindner, Hans Jörg
Publisher: name: Wiley
Year: 2023

description: Die tiefroten-Fe- und die farblosen ZrCl2-Komplexe2 sind aus den doppelt verbrückten Biscyclopentadienen 1 leicht zugänglich. Eine erhebliche Torsion der beiden ekliptisch angeordneten Decks des konformativ starren Ligandengerüstes von 2 ermöglicht große “Öffnungswinkel” für die Koordinationssphäre des Metallzentrums.
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4Btumor suppressor gene
Creators: name: Suzuki, S.
name: Liu, N.
name: Nakagawa, T.
name: Kotake, Y.
name: Kitagawa, M.
name: Kitagawa, K.
name: Xiong, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A 42 kb region on human chromosome 9p21 encodes for three distinct tumor suppressors, p16INK4A, p14ARF and p15INK4B, and is altered in an estimated 30–40% of human tumors. The expression of the INK4A-ARF-INK4B gene cluster is silenced by polycomb during normal cell growth and is activated by oncogenic insults and during aging. How the polycomb is recruited to repress this gene cluster is unclear. Here, we show that expression of oncogenic Ras, which stimulates the expression of p15INK4B and p16INK4A, but not p14ARF, inhibits the expression of ANRIL (antisense non-coding RNA in the INK4 locus), a 3.8 kb-long non-coding RNA expressed in the opposite direction from INK4A-ARF-INK4B. We show that the p15INK4B locus is bound by SUZ12, a component of polycomb repression complex 2 (PRC2), and is H3K27-trimethylated. Notably, depletion of ANRIL disrupts the SUZ12 binding to the p15INK4B locus, increases the expression of p15INK4B, but not p16INK4A or p14ARF, and inhibits cellular proliferation. Finally, RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15INK4B locus.
Fluctuating defects in the incipient relaxor K$_{1-x}$Li$_x$TaO$_3$ (x=0.02)
Creators: name: Stock, C.
name: Gehring, P. M.
name: Xu, G.
name: Lamago, D.
name: Reznik, D.
name: Russina, M.
name: Wen, J.
name: Boatner, L. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report neutron scattering measurements of the structural correlations associated with the apparent relaxor transition in K$_{1-x}$Li$_x$TaO$_3$ for $x=0.02$ (KLT(0.02)). This compound displays a broad and frequency-dependent peak in the dielectric permittivity, which is the accepted hallmark of all relaxors. However, no evidence of elastic diffuse scattering or any soft mode anomaly is observed in KLT(0.02) [J. Wen et al., Phys. Rev. B 78, 144202 (2008)], a situation that diverges from that in other relaxors such as PbMg$_{1/3}$Nb$_{2/3}$O$_3$. We resolve this dichotomy by showing that the structural correlations associated with the transition in KLT(0.02) are purely dynamic at all temperatures, having a timescale on the order of $\sim$THz. These fluctuations are overdamped, non-propagating, and spatially uncorrelated. Identical measurements made on pure KTaO$_3$ show that they are absent (within experimental error) in the undoped parent material. They exhibit a temperature dependence that correlates well with the dielectric response, which suggests that they are associated with local ferroelectric regions induced by the Li$^+$ doping. The ferroelectric transition that is induced by the introduction of Li$^+$ cations is therefore characterized by quasistatic fluctuations, which represents a stark contrast to the soft harmonic-mode-driven transition observed in conventional perovskite ferroelectrics like PbTiO$_3$. The dynamic, glass-like, structural correlations in KLT(0.02) are much faster than those measured in random-field-based lead-based relaxors, which exhibit a frequency scale of order of $\sim$GHz and are comparatively better correlated spatially. Our results support the view that random fields give rise to the relaxor phenomena, and that the glass-like dynamics observed here characterize a nascent response.
description: (13 pages, 11 figures)
(401021) Stewart Roy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.