cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nanotechnology approach for targeted treatment of triple negative breast cancer
Creators: name: Al-Mahmood, Sumayah Abed Ahmed
Publisher: name: No Publisher Supplied
Year: 2016

description: Breast cancer is one of the most devastating diseases worldwide. Triple negative breast cancer cells (TNBCs) are defined by the lack of progesterone receptor (PR), estrogen receptor (ER), and epidermal growth factor receptor 2 (EGFR2) expressions. TNBCs account for 10%- 20% of all breast carcinomas. The study is aimed at examining the efficacy of gefitinib and EGFR-targeted siRNA delivered by liposomes for treating triple negative breast cancer (TNBC). The experiments were carried out using two types of human breast cancer (BC) cell lines MCF-7 (estrogen positive BC, EPBC) and MDA-MB 231(TNBC). EGFR-targeted siRNA and gefitinib were delivered by cationic and neutral liposomes, respectively. A fluorescence microscope was used to study cellular internalization of labeled liposomes and siRNA. The expression of the targeted mRNA was performed using quantitative reverse transcription PCR. Finally, cytotoxicity of liposomal siRNA and gefitinib alone or in combination was measured using the modified MTT assay with appropriate controls. It was found that liposomes effectively delivered siRNA into both types of BC cells and suppressed the expression of targeted EGFR mRNA. However, formulations without gefitinib did not influence significantly on the viability of BC cells. Free drug demonstrated the ability to kill both types of cancer cells. Nevertheless, toxicity of gefitinib in TNBC was 2.5 times lower when compared with EPBC cells. The delivery of the drug by liposomes significantly enhanced its toxicity (1.2 and 2.5 times in EPBC and TNBC, respectively). The combination of liposomal siRNA and liposomal gefitinib demonstrated exceptionally high cytotoxicity when compared with the free drug (143 and 62 times higher in EPBC and TNBC, respectively). Suppression of EGFR mRNA effectively suppressed resistance of TNBC cells to gefitinib. The data obtained support the proposed approach and showed high potential of liposomal EGFR siRNA in combination with liposomal gefitinib in treatment of TNBC.
Additional file 3: of Regulatory remodeling in the allo-tetraploid frog Xenopus laevis
Creators: name: Dei Elurbe
name: Paranjpe, Sarita
name: Georgiou, Georgios
name: Kruijsbergen, Ila Van
name: Bogdanovic, Ozren
name: Gibeaux, Romain
name: Heald, Rebecca
name: Lister, Ryan
name: Huynen, Martijn
name: Heeringen, Simon Van
name: Veenstra, Gert
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Containing supplemental figures. (DOCX 1833 kb)
Applying design science to address health system problems
Creators: name: Appel, Lora
Publisher: name: No Publisher Supplied
Year: 2016

description: This study focused on two novel elements: studying the phenomenon of ‘clinician anonymity’ and its effects on inter-professional communication in hospital practice and applying design science theory and methodology to understand and address communication problems.   Healthcare is characterized by “more to do, more to know, more to manage, and more people involved than ever before.” This reality brings challenges to staff working in rapidly changing teams and stressful environments. The inability to recognize colleagues and the general lack of familiarity within teams undermines the effective collaboration that is critical to the delivery of patient care. This phenomenon, termed ‘clinician anonymity,’ was neither well defined nor understood, and few studies focused on interventions that addressed its causes and effects.   In order to evaluate how an intervention, both the design of an artifact and the process of its design, influence the phenomenon of clinician anonymity, a longitudinal, mixed methods (observations, interviews, surveys) study was conducted at a large urban teaching hospital in Toronto, Canada. Based on existing frameworks and drawing from initial observations, a theoretical model of clinician anonymity was developed. The model informed the initial requirements for ‘Face2Name,’ a tool designed to act on the communication practices linked to anonymity. Pre- and post-intervention data comprising of 158 hours of observations over 8 months, 14 semi-structured interviews, and over 250 surveys were collected at four points in time.   Results showed strong evidence of clinician anonymity in hospitals and revealed that the predominant cause is the nature of teaching hospitals, characterized by rapidly changing fluid teams, organizational structures and power dynamics between professions that dictate how collaborative processes and standard procedures are performed. Evaluation of the intervention confirmed the benefits of a visual tool on recall and staff satisfaction and user feedback contributed to making each subsequent iteration better suited to staff workflow and the hospital environment. Results also revealed that the process of designing and deploying the tool was more effective in addressing the problem of anonymity than the artifact itself, confirming a main tenet of design science that the intervention is both process and resulting product.  Findings from this study are of value within and also outside the hospital, generalizable to other environments with fluid teams or with similar institutional cultures. Moreover, the reflective process intrinsic to design science provided considerable insights on how to conduct future design studies in the context of communication research.
Additional file 5: of Regulatory remodeling in the allo-tetraploid frog Xenopus laevis
Creators: name: Dei Elurbe
name: Paranjpe, Sarita
name: Georgiou, Georgios
name: Kruijsbergen, Ila Van
name: Bogdanovic, Ozren
name: Gibeaux, Romain
name: Heald, Rebecca
name: Lister, Ryan
name: Huynen, Martijn
name: Heeringen, Simon Van
name: Veenstra, Gert
Publisher: name: Figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: With a supplemental note on the time required to fix pre-existing genomic variation in the population after hybridization. (DOC 38 kb)
Dyscolus Dejean 1831
Creators: name: Moret, Pierre
name: Murienne, Jérôme
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Dyscolus

description: Genus Dyscolus Dejean, 1831
Dyscolus Dejean, 1831: 437. Type species: Dyscolus memnonius Dejean, 1831, by subsequent designation (Chaudoir 1878: 343).
Hydrodyscolus Moret, 1996: 498. syn. nov.
Dyscolus – Moret 1989: 143.
The revision of the sequenced species led us to re-examine related material and to describe three new species of which we do not have DNA data, but which can be readily separated from the sequenced taxa (Dyscolus placitus Moret sp. nov., D. rivinus Moret sp. nov. and D. verecundissimus Moret sp. nov.).
All the species under study share the following characters, which are, therefore, not repeatedly mentioned in the descriptions of the new species: labrum with six setae near apical margin; clypeus with two pairs of setae; two supraorbital setae each side; mentum with one pair of setae, submentum with two pairs of setae (except in the species of the hirsutus and verecundus groups, which may have additional submental setae); pronotum with two pairs of lateral setae, the distal one located near the widest point of pronotum, the basal one near or at the laterobasal angle (except D. donosoi Moret sp. nov. which lacks the basal seta); parascutellar setiferous pore present; metathoracic wings reduced and metepisternum very short (except in D. eleonorae Moret sp. nov.).
The order in which these 25 new species are presented below is based on broad biogeographic and ecological groupings and on resemblances in external morphology, in order to make comparisons and identifications easier. The five resulting sections are: 1/ full-winged montane forest species (pp. 11–13); 2/ riparian wingless species of the montane forest (pp. 13–18); 3/ wingless, non-riparian species of the montane forest (pp. 18–36); 4/ riparian species of the páramo (pp. 36–42); 5/ non-riparian species of the páramo (pp. 42–51).
All the new species are authored by P. Moret.
description: Published as part of Moret, Pierre & Murienne, Jérôme, 2020, Integrative taxonomy of the genus Dyscolus (Coleoptera, Carabidae, Platynini) in Ecuadorian Andes, pp. 1-55 in European Journal of Taxonomy 646 on page 10, DOI: 10.5852/ejt.2020.646, http://zenodo.org/record/3829682
Additional file 1: Table S1. of Obesity and socioeconomic disadvantage in midlife female public sector employees: a cohort study
Creators: name: Hiilamo, Aapo
name: Lallukka, Tea
name: Mänty, Minna
name: Kouvonen, Anne
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Virology
subject: Computational Biology

description: Odds ratios (95% confidence intervals) for associations between baseline (Phase 1) body weight status and socioeconomic disadvantage as dependent variables at Phases 1–3 repeated measures analysis (GEE), the Helsinki Health Study, Finland, 2000–2012. (DOCX 83 kb)
Cryptodesmoides feae Pocock 1895
Creators: name: Likhitrakarn, Natdanai
name: Jirapatrasilp, Parin
name: Golovatch, Sergei I.
name: Panha, Somsak
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Polydesmida
Cryptodesmidae
Cryptodesmoides
Cryptodesmoides feae

description: 91. Cryptodesmoides feae Pocock, 1895
Cryptodesmoides feae Pocock, 1895: 790 (D).
Cryptodesmoides Feae — Attems, 1914: 68 (D).
Cryptodesmoides feae — Jeekel, 1965b: 123 (L); Hoffman, 1961: 407 (M).
Record from Myanmar: Palon in Pegu (Pocock 1895). Based on the female holotype collected from Palon in Pegu, deposited either in the London or Genoa Museum.
Remark. This monotypic genus is still dubious (Hoffman 1961; Golovatch 2015), as the species is only known from the female sex.
description: Published as part of Likhitrakarn, Natdanai, Jirapatrasilp, Parin, Golovatch, Sergei I. & Panha, Somsak, 2017, A checklist of the millipedes (Diplopoda) of Myanmar, with an updated list of Leonardo Fea's collecting localities, pp. 1-46 in Zootaxa 4350 (1) on page 28, DOI: 10.11646/zootaxa.4350.1.1, http://zenodo.org/record/1050931
The care of art and artifacts subjected to the law enforcement process
Creators: name: Archer, Jacob B.
Publisher: name: No Publisher Supplied
Year: 2016

description: This thesis is intended to serve as a guide for law enforcement officers on how to care for art and artifacts subjected to the law enforcement process. Law enforcement officers may encounter art and artifacts in various ways, such as through seizure, unexpected finds, and planned recovery operations.  Law enforcement officers have a duty to properly care for property, to include cultural property objects such as art and artifacts, while in their custody and control, but art and artifacts often require care beyond the routine handling generally afforded to common property items. This thesis will offer suggestions for the law enforcement officer on how to recognize art and artifacts in the field and how to subsequently handle and care for same. These suggestions are meant to be integrated into existing law enforcement policies and procedures so as to realistically account for the time, skill, and financial resources associated with law enforcement officers and their respective agencies, all the while maintaining adherence to generally accepted evidence collection practices.
KIF1C Variants Are Associated with Hypomyelination, Ataxia, Tremor, and Dystonia in Fraternal Twins
Creators: Marchionni, Enrica
Méneret, Aurélie
Keren, Boris
Melki, Judith
Denier, Christian
Durr, Alexandra
Apartis, Emmanuelle
Boespflug-Tanguy, Odile
Mochel, Fanny
Publisher: name: Columbia University
Year: 2019
Subjects: Kinesin
Diseases in twins
Movement disorders--Etiology
Dystonia
Tremor
Ataxia
Leukodystrophy

description: Background: KIF1C (Kinesin Family Member 1C) variants have been associated with hereditary spastic paraplegia and spastic ataxia. Case report: We report fraternal twins presenting with cerebellar ataxia and dystonic tremor. Their brain MRI showed a hypomyelinating leukoencephalopathy. Whole exome sequencing identified a homozygous KIF1C variant in both patients. Discussion: KIF1C variants can manifest as a complex movement disorder with cerebellar ataxia and dystonic tremor. KIF1C variants may also cause a hypomyelinating leukoencephalopathy.
Additional file 2: Table S2. of Obesity and socioeconomic disadvantage in midlife female public sector employees: a cohort study
Creators: name: Hiilamo, Aapo
name: Lallukka, Tea
name: Mänty, Minna
name: Kouvonen, Anne
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: Odds ratios (95% confidence intervals) for associations of baseline (Phase 1) body weight status and the changes in socioeconomic disadvantages through Phases 1–3 among women, time by group interaction, repeated measures analysis (logistic regression with random intercept for subjects), the Helsinki Health Study, Finland, 2000–2012. (DOCX 97 kb)
Cryptocorypha perplexa Golovatch and VandenSpiegel 2015
Creators: name: Likhitrakarn, Natdanai
name: Jirapatrasilp, Parin
name: Golovatch, Sergei I.
name: Panha, Somsak
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Polydesmida
Pyrgodesmidae
Cryptocorypha
Cryptocorypha perplexa

description: 92. Cryptocorypha perplexa Golovatch and VandenSpiegel, 2015
Cryptocorypha perplexa Golovatch and VandenSpiegel, 2015b: 27 (D).
Record from Myanmar: southern Chin State, above Kampetlet, below Mountain Oasis Resort, 1,585 m a.s.l., 21˚11′43.6″N, 94˚02′1.1″N (Golovatch and VandenSpiegel 2015b). The holotype and two paratypes are in the Senckenberg Museum, while one male paratype is in the Moscow Museum.
description: Published as part of Likhitrakarn, Natdanai, Jirapatrasilp, Parin, Golovatch, Sergei I. & Panha, Somsak, 2017, A checklist of the millipedes (Diplopoda) of Myanmar, with an updated list of Leonardo Fea's collecting localities, pp. 1-46 in Zootaxa 4350 (1) on page 28, DOI: 10.11646/zootaxa.4350.1.1, http://zenodo.org/record/1050931
Workshop, "Git - no fear", WSL PYRN Workshop, 2025
Creators: name: Suter, Christoph
name: Hänni, Cyrill
Publisher: name: Zenodo
Year: 2025
Subjects: Open Research Data
Version Control
Git
Open Science
Research Data Maangement

description: This PDF contains the support materialfor the "Git - no fear" PYRN Workshop, which took place at the DACH permafrost conference in Davos on January 8, 2025. This workshop covers the basics of Git and targets young researchers that have no previous familiarity with Git.
Refiguring universalisms
Creators: name: Arenger, Ben
Publisher: name: No Publisher Supplied
Year: 2016

description: This dissertation seeks to understand why novels of the post-Franco period have engaged with the theme of universality. The project traces the evolution of the terms “universal,” “universalism” and “universality” in the twentieth century, and explains the ways in which postmodernist fiction and literary theory have criticized these notions for their tendency to assert master narratives at the expense of marginalized cultures. Although their association with imperial discourses has contaminated universalisms, it is argued that three metafictional novels by authors Bernardo Atxaga, Enrique Vila-Matas, and Javier Cercas attempt to move beyond the particular by affirming the interconnectedness of humans and nonhumans. Drawing on ecological theory and continental philosophy, this project engages a close reading of the primary texts and concludes by proposing new cosmological understandings of selfhood. It is shown that Atxaga, Vila-Matas, and Cercas highlight literature’s capacity to forge new networks of relationship between humans, nature, material objects, and historical influence.
Additional file 1: of The relative risk of second primary cancers in Austriaâ  s western states: a retrospective cohort study
Creators: name: Preyer, Oliver
name: Concin, Nicole
name: Obermair, Andreas
name: Concin, Hans
name: Ulmer, Hanno
name: Oberaigner, Willi
Publisher: name: Figshare
Year: 2017
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology

description: SIRs of second primary cancer by type of first primary cancer and sex. Standard incidence ratios of all second primary cancers analysed are provided by type of first primary cancer and sex. (DOC 58Â kb)
Using Digital Learning Objects for Instructional Support for Faculty in Agricultural Sciences: A Pilot Study
Creators: name: Dong, Hanwen
name: Albro, Maggie
Publisher: name: OSF
Year: 2023
Subjects: Agricultural Librarianship
Digital Learning Objects
Information Literacy
Land-grant Institutions
Liaison Librarian
Library Collaboration

description: Presentation at The Annual Association of College and Research Libraries Science and Technology Section Virtual Research Forum (Virtual); 2024
Optimal design of life testing for Weibull dsitrbution lifetime units
Creators: name: Barcelos Cordeiro, Juliana
Publisher: name: No Publisher Supplied
Year: 2016

description: Accelerated life testing of manufactured units is performed in order to speed up testing through either reducing the time required for testing or establishing a predetermined number of failures to stop the test. In this research we develop two cost models for a Type-II censored testing for Weibull distribution life time units. We determine the optimal sample size on test which minimizes the expected total cost of performing the life testing when the parameters of the Weibull distribution are either fixed or unknown. Numerical examples are included to illustrate the cost models based on real data applications.
Nympharescus aemulus Sekerka 2016, comb. nov.
Creators: name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Nympharescus
Nympharescus aemulus

description: Nympharescus aemulus (Waterhouse, 1881) comb. nov.
Arescus aemulus Waterhouse, 1881: 266 (original description, incl. colour fig.).
Type locality. ‘ Ecuador, Sarayacu [according to the introduction of the paper]’ [= Ecuador, Pastaza Province, Sarayacu, approx. 1°44′S, 73°30′W, 350–400 m a.s.l.]
Type material examined. HOLOTYPE: pinned: ‘Type [w, p, s, circular label with red frame] || Sarayacu, | E. Ecuador | C.Buckley. | 91—97. [w, p, cb] || Arescus | aemulus. | (Type) C.Waterh. [w, hw by Waterhouse, s]’ (BMNH).
Remarks. WATERHOUSE (1881) described this species based on a single specimen, collected from Sarayacu situated in the lowlands of the Pastaza Province on the Bobonaza River. He mentioned and illustrated that this species had a peculiar asymmetric pattern. WEISE (1911) transferred it to Chelobasis Gray, 1832 and until recently it was only listed in catalogues (see UHMANN 1957a). STAINES (2009) revised Chelobasis, redescribed the species and provided additional faunistic data for it.
Examination of the holotype revealed that this species actually belongs to the genus Nympharescus Weise, 1905 as it has a seta present in all four pronotal corners while Chelobasis has seta present only in the anterior corners. Even if the setae have been broken off, the swollen tubercle which serves as their base remains and allows to infer the presence of this character. The holotype of A. aemulus has all four setae clearly visible and the specimen depicted in STAINES (2009) is actually the holotype and its locality was erroneously listed as in the Napo province in the material examined. Additional faunistic records published by STAINES (2009), from the western slopes of the Andes, are not adopted here, as it is unlikely they are conspecific with the holotype, which was collected in the Amazonian lowlands of Ecuador.
Distribution. Ecuador: Pastaza (WATERHOUSE 1881).
description: Published as part of Sekerka, Lukáš, 2016, Taxonomic and nomenclatural changes in Cassidinae (Coleoptera: Chrysomelidae), pp. 275-344 in Acta Entomologica Musei Nationalis Pragae 56 (1) on page 281, DOI: 10.5281/zenodo.5305725
Additional file 3: Table S3. of Obesity and socioeconomic disadvantage in midlife female public sector employees: a cohort study
Creators: name: Hiilamo, Aapo
name: Lallukka, Tea
name: Mänty, Minna
name: Kouvonen, Anne
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Odds ratios (95% confidence intervals) for associations time variant body weight status and socioeconomic disadvantage at Phases 1–3 among women, repeated measures analysis (GEE), the Helsinki Health Study, Finland, 2000–2012. (DOCX 77 kb)
Author Response to Letter to the Editor
Creators: Ha, Jongmok
Na, Boo Suk
Ahn, Jong Hyeon
Kim, Minkyeong
Kim, Jae Woo
Lee, Jae Hyeok
Cho, Jin Whan
Kim, Ji Sun
Youn, Jinyoung
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Chorea
subject: Paraneoplastic syndromes
subject: Diagnostic imaging
subject: Amantadine
subject: Neurosciences
subject: FOS: Clinical medicine

description: This is an author response to the letter by doctors Nicholas Doher and Harsh V Gupta. Despite the narrow indication for the dopamine transporter (DAT) scan to distinguish essential tremor from Parkinsonian syndromes, as approved by the Food and Drug Administration (FDA), DAT imaging is utilised for various other clinical symptoms in patients with parkinsonism. DAT scan is the only non-invasive modality developed to assess functional integrity of the dopaminergic system currently used in clinical practice, and could give valuable clinical information for selected patients. The authors believe that the approved indication of the DAT scan will be broadened to meet its versatile diagnostic potential.
Reduction in epistemology
Creators: name: Beddor, Bob
Publisher: name: No Publisher Supplied
Year: 2016

description: This dissertation centers on two questions:  (1)  Can we explain epistemic facts in terms of non-epistemic facts?  (2)  What is the most explanatorily basic notion within the epistemic realm?        Many philosophers are attracted to the idea that the epistemic is reducible to the natural:  facts about epistemic justification, knowledge, and the like can be explained in terms of non-epistemic facts.  How could such a reduction be achieved?  Chapter One explores the two leading proposals in the literature:  process reliabilism and mentalist evidentialism.  I argue that both of these approaches flounder when it comes to explaining epistemic defeat (cases where an individual gets some evidence in favor of a belief, which is then trumped by countervailing evidence).  The standard process reliabilist treatment of defeat faces counterexamples, and leading evidentialist treatments of defeat either fall victim to the same fate or fail to be reductive.         Chapter Two explores a different reductive strategy.  I suggest that we should pursue the path of semantic ascent:  we should focus on epistemic linguistic expressions and seek to define them without recourse to epistemic notions.  Specifically, I develop  an ‘attitudinal’ semantics for a variety of epistemic expressions, according to which epistemic expressions are analyzed in terms of the conative attitudes that give rise to them.  The resulting semantics is reductive; in addition, it offers to explain some of the striking commonalities between epistemic and ethical discourse.      Chapter Three considers reduction within the epistemic domain.  Recent epistemology has seen the rise of ‘Knowledge First’ epistemology, according to which knowledge is the most basic explanatorily basic epistemic notion.  I advance an alternative picture, according to which epistemic certainty is explanatorily fundamental.  After developing a context-sensitive semantics for certainty ascriptions, I go on to put certainty to explanatory work.  I argue that a wide range of epistemic phenomena—including epistemic modals, evidential probability, and knowledge itself—can be profitably analyzed in terms of certainty.
Tremor Control Devices for Essential Tremor: A Systematic Literature Review
Creators: Castrillo-Fraile, Victoria
Peña, Elena Casas
Gabriel y Galán, Jose Maria Trejo
Delgado-López, Pedro-David
Collazo, Carla
Cubo, Esther
Publisher: name: Columbia University
Year: 2019
Subjects: Tremor
Movement disorders--Treatment
Medical technology--Evaluation
Prosthesis
Arm

description: Background: There is a growing interest in nonpharmacological approaches for essential tremor (ET), including tremor cancelation devices. However, the true efficacy of such devices in ET remains unclear. Methods: A systematic literature review was conducted using standardized criteria regarding efficacy and comfortability. Devices focused on design or experimental testing in which tremor was simulated in a robot were excluded. Results: Out of 324 articles initially identified, 12 articles were included. Orthoses using biomechanical loading and neuromodulation with electrical stimulation, and external tremor cancelation devices, were the main interventions used to suppress tremor. All devices were designed to control tremor of the upper limbs at different anatomical locations. Overall, an average tremor attenuation of 50–98% was reported (level of evidence III). Interference with voluntary movements and portability was described as the main drawback. Discussion: In conclusion, this review highlights the growing interest in emerging tremor control devices and the importance of assessing comfort without affecting voluntary movements. However, the level of evidence regarding the efficacy of these tremor control devices remains low. An integrated multidisciplinary combination approach of engineering, robotics, physiology, physiotherapy, and clinical assessment is needed to improve the quality of non-pharmacological interventions for ET.
Slow Orthostatic Tremor: Review of the Current Evidence
Creators: Hassan, Anhar
Caviness, John N.
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Tremor
subject: Electrophysiology
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Orthostatic tremor (OT) is defined as tremor in the legs and trunk evoked during standing. While the classical description is tremor of ≥13 Hz, slower frequencies are recognized. There is disagreement as to whether the latter represents a slow variant of classical OT, or different tremor disorder(s) given frequent coexistent neurological disease. Methods: A systematic literature search of PubMed was performed in February 2019 for “slow orthostatic tremor” and related terms which generated 573 abstracts, of which 61 were included. Results: Between 1970 and 2019, there were 70 cases of electrophysiologically confirmed slow OT. Two-thirds were female, of mean age 60 years (range 26–86), and mean disease duration 6 years (range 0–32). One-third of cases were isolated, and two-thirds had a coexistent disorder(s), including parkinsonism (30%), ataxia (12%), and dystonia (10%). Postural arm tremor was present in 34%. Median tremor frequency was 6–7 Hz (range 3–12). Tremor bursts ranged from 50 to 150 ms duration, and were alternating or synchronous in antagonistic and/or analogous muscles. Low and high coherences were reported. Five cases (7%) had coexistent classical OT. Clonazepam was the most effective medication across all frequencies, and levodopa was effective for 4–7 Hz OT with coexistent parkinsonism. Two cases resolved with the treatment of Graves’ disease. Electrophysiology and imaging predominantly support a central tremor generator. Discussion: While multiple lines of evidence separate slow OT from classical OT, clinical and electrophysiological overlap may occur. Primary and secondary causes are identified, similar to classical OT. Further exploration to clarify these slow OT subtypes, clinically and neurophysiologically, is proposed.
Qualified health claims
Creators: name: Berhaupt Glickstein, Amanda F.
Publisher: name: No Publisher Supplied
Year: 2016

description: The US Food and Drug Administration (FDA) regulates and authors qualified health claims (QHCs) for voluntary use by companies on food and dietary supplement labels. QHCs communicate the scientific certainty about diet-disease relationships that are not supported by significant scientific agreement among qualified experts.     These claims emerged from a federal lawsuit that ruled QHCs a First Amendment issue.   Several lawsuits about the description of evidence (i.e. disclaimer) in QHCs led to case law and technical regulatory documents. The FDA must write more than one clear and succinct QHC for the same diet-disease relationship, and the disclaimer may not contradict the diet-disease relationship. However, research indicates consumers are confused by QHCs and are rarely used.     To catalogue their description of scientific certainty, a content analysis parsed the 53 currently-enforced QHCs. Thirty-six formats to communicate scientific evidence were found. Most demonstrate a reading level above 9th grade, describe the quality of evidence (“very weak”) and/or reference its consistency, while a quarter quantify the evidence (“two studies”).     A 2012 lawsuit over green tea QHCs prompted an investigation of seven QHCs pertaining to a green tea-cancer relationship designed to test stakeholder’s assumptions and arguments from the lawsuit and to understand the potential benefit of QHCs to companies. An online experiment was used to assess and to directly compare consumer comprehension of the scientific support implied by each of the claims and resulting intentions to purchase green tea.     Overall, consumers understood the level of evidence for the green tea-cancer relationship. Consumers who had made health-related dietary changes and considered health claims important reported greater purchase intentions after reading a green tea-cancer QHC. Consumers who read a claim written by the green tea company perceived greater evidence for the green tea-cancer relationship, were more confident in the relationship, and reported greater purchase intentions than others. The currently enforced QHC resulted in lower scores for perceived level of evidence for and confidence in the green tea-cancer relationship, and purchase intentions for green tea when compared with QHCs written by the green tea company and higher scores when compared to other FDA QHCs. The current QHC appears to be a compromise between claims written by the green tea company and other QHCs written by FDA.
Ataxic Gait in Essential Tremor: A Disease-associated Feature?
Creators: Rao, Ashwini K.
Louis, Elan D.
Publisher: name: Columbia University
Year: 2019
Subjects: subject: Tremor
subject: Movement disorders
subject: Gait disorders
subject: Equilibrium (Physiology)
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: While accumulating evidence suggests that balance and gait impairments are commonly seen in patients with essential tremor (ET), questions remain regarding their prevalence, their relationship with normal aging, whether they are similar to the impairments seen in spinocerebellar ataxias, their functional consequences, and whether some ET patients carry greater susceptibility. Methods: We conducted a literature search (until December 2018) on this topic. Results: We identified 23 articles on gait or balance impairments in ET. The prevalence of balance impairment (missteps on tandem walk test) was seven times higher in ET patients than controls. Gait impairments in ET included reduced speed, increased asymmetry, and impaired dynamic balance. While balance and gait problems worsened with age, ET patients were more impaired than controls, independent of age. The pattern of impairments seen in ET was qualitatively similar to that seen in spinocerebellar ataxias. Balance and gait impairments resulted in greater number of near falls in ET patients. Factors associated with balance and gait impairments in ET included age, presence of tremor in midline structures, and cognitive dysfunction. Discussion: Accumulating evidence suggests that balance and gait impairments are common in ET patients and occur to a greater extent in controls. Thus, they represent a disease-associated feature. These impairments, which are qualitatively similar to those seen in spinocerebellar ataxias, are not merely subclinical but result in difficulty performing functional tasks and increase falls risk. A subset of patients is more susceptible to balance and gait impairments. The full spectrum of impairments remains to be characterized.
Additional file 4: Table S4. of Obesity and socioeconomic disadvantage in midlife female public sector employees: a cohort study
Creators: name: Hiilamo, Aapo
name: Lallukka, Tea
name: Mänty, Minna
name: Kouvonen, Anne
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: Science Policy
subject: Computational Biology

description: Response rates at Phases 2 and 3 by baseline body weight status and indicators of socioeconomic disadvantage among women, the Helsinki Health Study, Finland, 2000–2012. (DOCX 65 kb)
Additional file 1: of Effectiveness of behavioral change techniques employed in eHealth interventions designed to improve glycemic control in persons with poorly controlled type 2 diabetes: a systematic review and meta-analysis protocol
Creators: name: Mihiretu Kebede
name: Christianson, Lara
name: Zohaib Khan
name: Heise, Thomas
name: Pischke, Claudia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: PRISMA-P 2015 checklist (DOC 100Â kb)
A numerical study of the thermal effects on local water bodies due to changes in the environment
Creators: name: Bharadwaj, Nikhil
Publisher: name: No Publisher Supplied
Year: 2016

description: The study of global warming and its effects is becoming increasingly popular due to steady increase in the environmental pollution. Local warming of a particular place which in turn contributes to the global warming can be studied through temperature variations of the local water bodies due to changes in the environment. In the present work, using the weather data obtained for New Brunswick, a general trend for variation in ambient temperature during the year is determined by fitting suitable curves using curve-fitting technique. Using this, the transient temperature distribution in the lake is determined numerically. The effect of many driving parameters such as ambient temperature, relative humidity, wind speed, solar flux, equilibrium temperature, diffusivity and surface heat loss on the temperatures of the lake are studied in detail using a one-dimensional transient model. The governing equations are solved numerically using finite differences method. The results of this work show the transient temperature distribution in the lake over the year and the variation in temperatures due to external changes in the environment.
Nympharescus laevicollis Sekerka 2016, comb. nov.
Creators: name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Nympharescus
Nympharescus laevicollis

description: Nympharescus laevicollis (Waterhouse, 1879) comb. nov.
Arescus laevicollis Waterhouse, 1879: 427 (original description).
Arescus waterhousei Duvivier, 1885: 249 (original description). WEISE (1911): 12 (synonymy).
Type locality. ‘ Colombia, Medellin [according to the introduction of the paper]’.
Type material examined. HOLOTYPE: pinned (missing both antennae): ‘Type [w, p, s, circular label with red frame] || Medellin | 78·39 [w, hw, cb] || Arescus | laevicollis, | (Type) C.Waterh. [w, hw by Waterhouse, s]’ (BMNH).
Remarks. WATERHOUSE (1879) described this species from an unknown number of specimens collected by Mr. Salmon at Medellin. The description was probably based on a singleton, as he provided only a single length measurement and the description of its colouration perfectly matches the specimen (species of Arescini display great colour variation). WEISE (1911) transferred the species to Chelobasis and until a recent revision it was only listed in catalogues (see UHMANN 1957a). This species is so far known only from the type specimen redescribed by STAINES (2009). Examination of the specimen revealed that it actually belongs to the genus Nympharescus as it has a seta present in all four pronotal corners (Chelobasis has a seta present only in the anterior pronotal corners). Even if the setae have been broken off, the swollen tubercle which serves as their base remains and allows to infer the presence of this character. The type of A. laevicollis has frontal left and hind right setae broken, but the remaining two are clearly visible and the specimen depicted in STAINES (2009) is actually the holotype.
DUVIVIER (1885) described Arescus waterhousei from ‘ Cauca (Amaz.)’. WEISE (1911) considered it as synonym of A. laevicollis. I did not examine its type so I retain A. waterhousei as synonym of A. laevicollis. Its type locality probably refers to the Cauca Department of the former Gran Colombia nowadays split in four departments: Antioquia, Cauca, Chocó and Valle de Cauca. Adding to the confusion, Duvivier used the abbreviation ‘Amaz.’, which almost certainly means Amazon, while all aforementioned departments are situated in the western part of Colombia and do not reach the Amazon Basin.
Distribution. Colombia: Antioquia (WATERHOUSE 1879).
description: Published as part of Sekerka, Lukáš, 2016, Taxonomic and nomenclatural changes in Cassidinae (Coleoptera: Chrysomelidae), pp. 275-344 in Acta Entomologica Musei Nationalis Pragae 56 (1) on pages 281-282, DOI: 10.5281/zenodo.5305725
Financial Table Extraction in Image Documents
Creators: name: Watson, William
name: Liu, Bo
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Table extraction has long been a pervasive problem in financial services. This is more challenging in the image domain, where content is locked behind cumbersome pixel format. Luckily, advances in deep learning for image segmentation, OCR, and sequence modeling provides the necessary heavy lifting to achieve impressive results. This paper presents an end-to-end pipeline for identifying, extracting and transcribing tabular content in image documents, while retaining the original spatial relations with high fidelity.
Psychotropic society
Creators: name: Black, Sara Elizabeth
Publisher: name: No Publisher Supplied
Year: 2016

description: “Psychotropic Society” traces the numerous ways in which the everyday consumption of psychotropic substances in the nineteenth century blurred the lines between science and stimulation, calculated therapeutic practice and chemically induced self-discovery. It focuses on opium, morphine, ether, chloroform, cocaine, and hashish—all substances used both to control pain and to produce pleasure, at a time when the boundaries between medical and recreational drug use were ill defined and permeable. Doctors, pharmacists, and the state sought to mobilize these substances to relieve pain in the birthing room and the battlefield, to restore sanity in the asylum, and to shore up their own authority over the bodies of citizens. Determining proper dosages and discovering potential side effects of these drugs are crucial chapters in the history of therapeutic progress and medical ethics, which this dissertation explores. Yet these projects were intertwined with doctors’ self-experimentation, bohemian recreational drug use, and popular fascination with the increasingly common figure of the addict. “Psychotropic Society” reveals the centrality of these varied and seemingly liminal uses of drugs to the emergence of modern French medicine and therapeutic regimens that shaped the ways in which citizens experienced the world at key moments in their lives.   Drugs offered doctors and pharmacists powerful ways to legitimate their professions. It was not simply that they acted as gatekeepers to these powerful substances. Rather, medical professionals emphasized the danger and heroism of their experiments with drugs on their own bodies in the name of therapeutic progress. Psychotropic drugs were also at the center of a new claim by French citizens: the right to freedom from pain. Drugs’ widespread availability empowered patients to self-medicate, transcending the quotidian discomforts of modern life. Yet this freedom came at a high potential cost for a nation that saw itself as a collection of liberal subjects. Drugs cast into doubt the notion of the liberal self as autonomous, rational, and driven by free will. Instead, these substances revealed that self to be malleable, sometimes passive, and mediated through the body’s chemical needs and desires.
Basiprionota octomaculata
Creators: name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Basiprionota
Basiprionota octomaculata

description: Basiprionota octomaculata (Boheman, 1850)
Prioptera 8-maculata Boheman, 1850: 56 (original description).
Prioptera gibbosa Baly, 1863: 9 (original description), syn. nov.
Type localities. Prioptera gibbosa: ‘ Tringanee’ [= Malaysia, Terengganu]; P. 8-maculata: ‘Java’.
Type material examined. Prioptera gibbosa: HOLOTYPE: ♀, pinned, ‘Ting [w, hw by Baly, cb] || Type [w, p, s, c, rf] || Tringano [hw] | Baly Coll. | 1905—54. [w, p, cb] || Prioptera | gibbosa | Baly | Malay Penninsula [g, hw by Baly, cb] || Coll | Castelnau | Stevens | Type [hw by Baly on underside of preceding label]’ (BMNH).
Prioptera 8-maculata: LECTOTYPE (designated by BOROWIEC 1999a): ♀, pinned, ‘ Java [w, p, s] || Mhm. [w, p, cb] || Type. [w, p, s] || LECTOTYPE | des. L. Borowiec [r, p, cb] || NHRS-SRAH | 000000084 [w, p, cb]’ (NHRS).
Remarks. BALY (1863) did not state how many specimens he had at his disposal. However, he most likely had only a singleton based on the description of its colouration and it is here considered as holotype. Baly did not provide any comparative diagnosis to other species, but simply stated in the foreword of the publication that he acquired the material too late to include it in the supplement to Monographia Cassididarum (BOHEMAN 1862). Baly purchased this specimen on Stevenʼs auctions and it originally came from material of Laporte de Castelnau.
Basiprionota gibbosa is very characteristic due to its strongly convex elytra with postscutellar tubercle and yellow antennae and the only similar species is B. octomaculata Boheman, 1850. BALY (1863) described B. gibbosa from a female specimen that perfectly matches the lectotype of B. octomaculata. Basiprionota gibbosa is thus considered a junior subjective synonym of the latter species.
The type locality of B. gibbosa, ‘Tringanee’, refers either to the State of Terengganu or city Kuala Terengganu situated in the mouth of the Terengganu River in Malaysia.
Distribution. Indonesia: Java (BOHEMAN 1850), Sumatra (SPAETH 1925, BOROWIEC 2009a); Malaysia: Terengganu (BALY 1863).
description: Published as part of Sekerka, Lukáš, 2016, Taxonomic and nomenclatural changes in Cassidinae (Coleoptera: Chrysomelidae), pp. 275-344 in Acta Entomologica Musei Nationalis Pragae 56 (1) on page 282, DOI: 10.5281/zenodo.5305725
Additional file 2: of Effectiveness of behavioral change techniques employed in eHealth interventions designed to improve glycemic control in persons with poorly controlled type 2 diabetes: a systematic review and meta-analysis protocol
Creators: name: Mihiretu Kebede
name: Christianson, Lara
name: Zohaib Khan
name: Heise, Thomas
name: Pischke, Claudia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: PubMed search strategy (DOC 34Â kb)
Agroiconota subvittata
Creators: name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Agroiconota
Agroiconota subvittata

description: Agroiconota subvittata (Boheman, 1855)
Coptocycla subvittata Boheman, 1855: 287 (original description).
Agroiconota carlobrivioi Borowiec, 2005: 64 (original description, incl. colour fig.), syn. nov.
Type localities. Agroiconota carlobrivioi: Peru, Madre de Dios Department, Puerto Maldonado. Coptocycla subvittata: ‘Bolivia’.
Type material examined. Coptocycla subvittata: HOLOTYPE: pinned, ‘ Boliv [w, p, s] || Guerin [w, p, s] || Type. [w, p, s] || NHRS-JLKB | 000020906 [w, p, cb]’ (NHRS).
Agroiconota carlobrivioi: PARATYPE: glued, ‘ PARATYPE | des.L.Borowiec [r, p, cb] || PERU Puerto | Maldonado [w, p, cb] || Dept.Madre de | Dios - C.Tello | XII.93 - I.94 [w, p, cb] || Agroiconota | carlobrivioi n. sp. | PARATYPE | des. L. Borowiec [w, p, cb]’ (LSPC).
Remarks. BOROWIEC (2005) described Agroiconota carlobrivioi based on its unique colour pattern formed by irregular red stripes on yellow elytra while all similar species have regular stripes with complete borders. However, the identity of A. subvittata was erroneously interpreted; its holotype has an identical pattern to A. carlobrivioi and is conspecific with it. Therefore I consider A. carlobrivioi a junior subjective synonym of A. subvittata. See also remarks under A. urbanae.
The type locality of A. carlobrivioi, Puerto Maldonado, was wrongly spelled in the original description as ‘Puerto Malonado’.
BOHEMAN (1855) did not precisely state how many specimens he had at his disposal but based on the single length measurement and characters mentioned in the description it is assumed he had a singleton.
Distribution. Bolivia: Beni; Brazil: Goiás; Peru: Madre de Dios, San Martín (BOROWIEC 2005).
description: Published as part of Sekerka, Lukáš, 2016, Taxonomic and nomenclatural changes in Cassidinae (Coleoptera: Chrysomelidae), pp. 275-344 in Acta Entomologica Musei Nationalis Pragae 56 (1) on pages 282-283, DOI: 10.5281/zenodo.5305725