cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Acute Stress Effects over Time on the Gene Expression and Neurotransmitter Patterns in the Carp (Cyprinus carpio) Brain
Creators: name: Pietsch, Constanze
name: Pawlak, Paulina
name: Konrad, Jonathan
Publisher: name: MDPI
Year: 2024

description: Changes in gene expression in carps’ brains over time following acute stressors has not been studied in detail so far. Consequently, a stress trial with juvenile common carp was conducted to investigate transcriptomic differences in four brain parts in response to acute negative stressors and feed reward, focusing on appetite-related genes, serotonergic and dopaminergic pathways, and other involved systems, at 30, 60, and 90 min after treatments. The treatments showed pronounced effects on the gene expression patterns across brain parts compared to control fish. Notably, npy expression increased in the telencephalon following negative stressors and feed reward, suggesting a stress-coping mechanism by promoting food intake. Unlike zebrafish, cart expression in carp showed varying responses, indicating species-specific regulation of appetite and stress. Serotonergic and dopaminergic pathways were also affected, with alterations in the respective receptors’ expression, confirming their roles in stress and reward processing. Additionally, this study highlights the involvement of the opioid- and gamma-aminobutyric acid systems in stress and feeding regulation across brain parts. Furthermore, principal component analyses revealed that neurotransmitter levels in the different brain parts contribute to the explained variance. These findings deepen our understanding of how different fish species react to acute stress and rewards.
Der Anteil des Augustiner-Generals Seripando an dem Trienter Dekret über die Rechtfertigung
Creators: name: Ehses, Stephan
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 23 Nr. 2 (1909): Römische Quartalschrift, Band 23, Heft 2
In-Vitro Measurement of Forces During Debridement with a Piezoelectric Ultrasonic Periodontal Scaler
Creators: name: Stutzer, Diego
name: Hofmann, Martin
name: Eick, Sigrun
name: Scharp, Nicole
name: Burger, Jürgen
name: Niederhauser, Thomas
Publisher: name: Quintessence Publishing
Year: 2024
Subjects: calculus
debridement
periodontal
piezoelectric
ultrasonic

description: Purpose: This study investigated the magnitude, direction, and temporal aspects of the force applied during instrumentation with a piezoelectric ultrasonic periodontal scaler, compared this force with recommendations in the literature, and assessed the influence of the profession (dentist or dental hygienist) and calculus hardness. Materials and Methods: The force applied by ten dental hygienists and six dentists during debridement of comparatively soft and hard artificial dental calculus with a piezoelectric ultrasonic scaler was recorded in-vitro. The total force and its components in three axes were statistically analysed. Results: During debridement of soft artificial dental calculus, the mean total force applied by dental hygienists was 0.34 N (± 0.18 N, range: 0.13 N to 0.59 N) and by dentists 0.28 N (± 0.33 N, range: 0.06 N to 0.95 N), and the total force exceeded 0.5 N approximately 23% and 14% of the time for dental hygienists and dentists, respectively. During debridement of hard artificial dental calculus, the mean total force applied by dental hygienists was 0.63 N (± 0.40 N, range: 0.28 N to 1.64 N) and by dentists 0.57 N (± 0.17 N, range: 0.34 N to 0.76 N); the total force exceeded 0.5 N more than half of the time for both professions. On average, dental hygienists applied 1.85x (p = 0.04) and dentists 2.04x (p = 0.06) higher force on hard than on soft artificial calculus. However, dental hygienists and dentists used similar forces during the debridement of both hard (p = 1.00) and soft (p = 0.26) calculus. Conclusion: The force applied during the debridement of hard artificial dental calculus was statistically significantly higher than during the debridement of soft artificial dental calculus. No statistically significant difference between dentists and dental hygienists was found. The force applied by both groups on soft and hard artificial dental calculus frequently exceeded recommended values.
sj-docx-1-pal-10.1177_08258597211073226 - Supplemental material for Prevalence and Predictors of Palliative Care Utilization among Hospitalized Patients with Diffuse Large B-Cell Lymphoma
Creators: name: Jackson, Inimfon
name: Etuk, Aniekeme
name: Jackson, Nsikak
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-pal-10.1177_08258597211073226 for Prevalence and Predictors of Palliative Care Utilization among Hospitalized Patients with Diffuse Large B-Cell Lymphoma by Inimfon Jackson, MD, MPH, PhD, Aniekeme Etuk, MD, MPH and Nsikak Jackson, MD, MSc, PhD in Journal of Palliative Care
sj-docx-4-aut-10.1177_13623613231158959 – Supplemental material for Factors influencing the mental health of autistic children and teenagers: Parents’ observations and experiences
Creators: name: Mukherjee, Suzanne
name: Beresford, Bryony
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-4-aut-10.1177_13623613231158959 for Factors influencing the mental health of autistic children and teenagers: Parents’ observations and experiences by Suzanne Mukherjee and Bryony Beresford in Autism
Elucidating the role of EP300/CBP mediated FOXO3 acetylation in tumorigenesis and cancer drug resistance
Creators: name: Mahmud, Zimam
Publisher: name: Imperial College London
Year: 2019

description: Forkhead Box O3 (FOXO3) is a tumour suppressor whose functional activity is predominantly regulated by post-translational modifications (PTMs). Of all PTMs, the best-studied PTM of FOXO proteins is phosphorylation, however, acetylation by EP300 or the CREB-binding protein (CBP) has been increasingly recognised as a novel axis regulating FOXO proteins. Herein, using the BT474 breast cancer cells and its lapatinib resistant derivative BT474 LapR cells, I observed that higher FOXO3 and acetylated Ac-FOXO3 levels correlate with lapatinib sensitivity. Subsequent ectopic expression of EP300, as well as CBP, led to an increase in acetylated-FOXO3 in sensitive, but not in resistant BT474 cells. Moreover, lapatinib sensitive BT474 cells exhibited enhanced lapatinib cytotoxicity upon over-expression of wild-type but not acetylation-deficient EP300 or CBP as revealed by drug sensitivity assays. Besides, using SIRT1/6 specific siRNAs and chemical inhibitor, I also found that SIRT1 and SIRT6 play a part in fine-tuning FOXO3 acetylation and lapatinib sensitivity. Notably, we next explored that not only SIRT1/6 but also SIRT2 plays a significant role in regulating FOXO3 acetylation and lapatinib sensitivity of BT474 and nasopharyngeal cancers. Taken together, these results suggest the involvement of acetyltransferases EP300/CBP and nuclear sirtuins in regulating FOXO3 acetylation and lapatinib sensitivity of breast cancers. Despite having a tumour-suppressive role, some reports suggested the oncogenic role of EP300 in the development and progression of cancers. To uncover this, I used Hs578T cells which have E-cadherin promoter hypermethylated. Interestingly, overexpression of EP300 led to the up-regulation of mesenchymal and stemness markers, increases in cell migration, invasion, anchorage-independent growth, and drug resistance. Moreover, genome-wide expression profiling identified Aldo-keto reductases AKR1C1-3 as positive modulators of cancer stemness and drug resistance, since their pharmacological inhibition with flufenamic acid restored both doxorubicin and paclitaxel sensitivity and reduced mammosphere formation. Thus, EP300 functions as an oncogene via the up-regulation of AKR1Cs in cells where the E-cadherin promoter is hypermethylated. This important finding offers the rationale of using current AKR1Cs inhibitors in the treatment of triple-negative breast cancers.
title: "Statua di fanciullo ammantato", Arte romana, inv. LXIX (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Ciccarello, Giulia
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Dr. Fr. Jos. Dölger, Der Exorzismus im altchristlichen Taufritual
Creators: name: Krebs, Engelbert
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 23 Nr. 1 (1909): Römische Quartalschrift, Band 23, Heft 1
C. M. Kaufmann, Der Menastempel und die Heiligtümer von Karm Abu Mina in der ägyptischen Mariûtwüste
Creators: name: Waal, Anton De
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 23 Nr. 1 (1909): Römische Quartalschrift, Band 23, Heft 1
Alternate passage divergence of wide chord transonic fan blades
Creators: name: Lu, Yaozhi
Publisher: name: Imperial College London
Year: 2019

description: Due to manufacturing tolerance and deterioration during operation, fan blades in the same engine exhibit geometric variability. The absence of symmetry will inevitably exacerbate and contribute to the complexities of running geometry prediction as the blade variability is bound to be amplified by aerodynamic and centrifugal loading. In this study, the fan blade untwist (which is the blade deformation between its static condition and running condition) related phenomenon known as Alternate Passage Divergence (APD) is addressed. As the name suggests, APD manifests as alternating passage geometry (and hence alternating tip stagger pattern) when the fan stage is operating close to/at peak efficiency condition. APD can introduce adverse influence on fan performance, aeroacoustics behaviour, and high cycle fatigue characteristics of the blade. In this study, the APD behaviours of two transonic fan blade designs are compared. The main objective of the study is to identify the parameters contributing to the APD phenomenon. After the formation of alternating tip stagger pattern, APD's unsteady effect can cause the blades from one group (segmented by tip stagger angle) to switch to the other, creating a travelling wave pattern around the circumference. It was found from numerical assessment on a randomly mis-staggered assembly that real engines can potentially experience such travelling disturbance and suffer fatigue damage. The phenomenon is termed APD-induced Non-Synchronous Vibration (NSV) and is abbreviated as NSV in this study. An idealised case is used to capture the bulk behaviour from the more complex cases in real engines and to decipher the underlying mechanism of this travelling disturbance. The results indicate that the driving force originates from the interaction between passage shock displacement and the passage geometry. Based on the findings on APD & NSV, vibration attenuation methods are explored. Using machine learning techniques, a passive attenuation method is found to minimise the chance of NSV manifestation for a given set of fan blades. Alternatively, active attenuation method is implemented through blade redesign which modifies the passage geometry.
Additional file 2 of IMP2ART: development of a multi-level programme theory integrating the COM-B model and the iPARIHS framework, to enhance implementation of supported self-management of asthma in primary care
Creators: name: Steed, Liz
name: Sheringham, Jessica
name: McClatchey, Kirstie
name: Hammersley, Vicky
name: Marsh, Viv
name: Morgan, Noelle
name: Jackson, Tracy
name: Holmes, Steve
name: Taylor, Stephanie
name: Pinnock, Hilary
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Additional file 2: Supplementary File 2. Full description of the IMP2ART Implementation Strategy with mapping to IPARIHS and COM-B
Wie eine zukunftsgerichtete Data Governance die Mehrfachverwendung von Daten ermöglicht
Creators: name: Bärtschi, Jonas
Publisher: name: Berner Fachhochschule, Wirtschaft
Year: 2024

description: «Open Government Data» ist erst der Anfang. Für die durchgehende Digitalisierung des öffentlichen Sektors braucht es eine solide Data Governance mit klaren Rollen, die auf eine Wiederverwendung von Daten ausgelegt ist.
sj-pdf-15-hpq-10.1177_13591053231159168 – Supplemental material for Effects of mental contrasting on sleep and associations with stress: A randomized controlled trial
Creators: name: Schmidt, Laura I
name: Neubauer, Andreas B
name: Stoffel, Martin
name: Ditzen, Beate
name: Schirmaier, Jana
name: Farrenkopf, Claudia
name: Sieverding, Monika
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: sj-pdf-15-hpq-10.1177_13591053231159168 for Effects of mental contrasting on sleep and associations with stress: A randomized controlled trial by Laura I Schmidt, Andreas B Neubauer, Martin Stoffel, Beate Ditzen, Jana Schirmaier, Claudia Farrenkopf and Monika Sieverding in Journal of Health Psychology
Gallium-68 radiolabelling and preclinical evaluation of the novel single chain fragment variable (scFv) TCT1067
Creators: name: Fu, Ruisi
Publisher: name: Imperial College London
Year: 2019

description: The combination of Positron Emission Tomography (PET) and the single chain fragment variable (scFv) provides a unique solution for PET imaging and drug development. scFv have faster pharmacokinetics while retaining the high specificity and high target affinity by only keeping the antigen-binding domain. PET imaging with scFv will benefit from this faster pharmacokinetics which matches the more accessible but short-lived PET radionuclide such as 68Ga. On the other hand, the high sensitivity of PET imaging could help reveal the unique pharmacokinetics of the drug conjugated scFv and accelerate its application. With these two advantages, a novel anti-HER2 scFv TCT1067 was investigated for PET imaging through trans-cyclooctene (TCO)/tetrazine based 68Ga labelling. In addition, the fragment-drug conjugate (FDC) MMAF-TCT1067 were also labelled by 68Ga for better understanding of its pharmacokinetics. A series of the TCT1067 conjugates were synthesized and radiolabelled with 68Ga while conserving the high specificity and high binding affinity. Based on the successful radiolabelling, a comparative PET study of the 68Ga labelled TCT1067 and MMAF-TCT1067 was carried out for the first time. Using the highly sensitive PET imaging, the distinctive early pharmacokinetics between the TCT1067 and the MMAF-TCT1067 were revealed.
Additional file 2 of Media exposure to climate change information and pro-environmental behavior: the role of climate change risk judgment
Creators: name: Vrselja, Ivana
name: Pandžić, Mario
name: Rihtarić, Martina Lotar
name: Ojala, Maria
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 2
Implementierung des Paediatric Yorkhill Malnutrition Score in einer Kinderklinik
Creators: name: Strahm, Rachel
name: Uhlmann, Katja
name: Wenger Lanz, Brigitte
name: Schmitt, Kai-Uwe
Publisher: name: Thieme
Year: 2024

description: Mangelernährung bei hospitalisierten Kindern und Jugendlichen ist eine interprofessionelle Herausforderung und kann negative Auswirkungen auf den Genesungsprozess haben. Damit eine Mangelernährung behandelt werden kann, ist es wichtig, bei Eintritt in die Klinik ein Screening durchzuführen und bei einem erhöhten Risiko geeignete Maßnahmen einzuleiten. Dieser Beitrag beschreibt die Herausforderungen und Auswirkungen bei der Implementierung des Paediatric Yorkhill Malnutrition Score (PYMS) als Screening-Tool in einer Kinderklinik.
Assessment of the management and clinical outcomes of patients with non-diabetic hyperglycaemia and newly diagnosed type 2 diabetes in primary care in England
Creators: name: Palladino, Raffaele
Publisher: name: Imperial College London
Year: 2019

description: Background It is unknown whether the detection of non-diabetic hyperglycaemia before the diagnosis of Type 2 diabetes is associated with vascular disease at time or following the diagnosis of Type 2 diabetes. Aim I assessed the association between glycaemic testing and detection of non-diabetic hyperglycaemia before the diagnosis of Type 2 diabetes is associated and vascular disease at time or following the diagnosis of Type 2 diabetes. Methods I identified 159,736 individuals with newly diagnosed Type 2 diabetes from the CPRD database in England between 2004 and 2017. I used logistic regression models to compare presence of vascular disease at the time of Type 2 diabetes diagnosis by prior glycaemic status. I employed time-partitioned Cox regression models to model differences in rates of vascular disease and mortality following the diagnosis of Type 2 diabetes. Results Half of the study population (49.9%) had at least one vascular disease, over one-third (37.4%) had microvascular disease, and almost a quarter (23.5%) had a diagnosed macrovascular disease at the time of Type 2 diabetes diagnosis. Individuals with prior non-diabetic hyperglycaemia were more likely to have microvascular disease and coronary heart disease at time of diagnosis of Type 2 diabetes. As compared with individuals with glycaemic values within the normal range in the three years before the diagnosis of Type 2 diabetes, those detected with non-diabetic hyperglycaemia had increased risk of microvascular disease that persisted up to 7.5 years. Conclusions Non-diabetic hyperglycaemia before diagnosis of Type 2 diabetes is associated with increased odds of microvascular disease and coronary heart disease in newly diagnosed Type 2 diabetes. It is also associated with increased rates of microvascular disease following the diagnosis of Type 2 diabetes. Detection of non-diabetic hyperglycaemia might represent an opportunity for a timely identification of NDH and specific clustering of NDH with other risk factors for T2D, which might prompt earlier assessment for risk factors and tailored cardiovascular risk reduction strategies during the NDH phase to reduce the burden of vascular disease.
Coactivator binding inhibitors targeting the androgen receptor
Creators: name: Qian, Chenming
Publisher: name: Imperial College London
Year: 2020

description: The Androgen receptor (AR) transcription pathway is known to be a key biological process in the growth of prostate cancer. To specifically interrupt this biological process without side effects, coactivator binding inhibitors (CBIs) have been developed which are designed to target a unique binding site called activation function 2 (AF-2) which is located in the AR ligand-binding domain (LBD). In this thesis, research was carried out to synthesize compounds which are able to block this protein-protein interface (PPI) and to develop a binding assay to quantify their effectiveness as blocking agents. In the synthetic work, to obtain a model compound for use as a positive control during the development of the CBI binding assay, a six-step synthesis of a known pyrimidine-based CBI with a‘FXXLF’ motif was completed. The final product was characterized spectroscopically and shown to be identical to that reported in the literature. In addition, to target another interesting binding site, binding function 3 (BF-3), several analogs of an indoline-indole based lead compound were designed and were successfully synthesized. An investigation into the oxidation of these to give indole-indole control compounds was also conducted. These BF-3 antagonists are ready for screening in the cell-based assay to produce inhibition data. For the biology part, a luciferase reporter (LR) assay and a fluorescence polarization (FP) assay were performed on both the AF-2 and BF-3 targeted model compounds. These two assays generated good inhibition data against the AR transcriptional activity and binding towards rat AR-LDB, respectively. The optimization of the FP assay was also successfully achieved with respect to the buffer components and the protocol. Finally, having successfully recorded the activities of the mentioned model compounds in the FP assay, an alpha-helix mimetic CBI which had been designed and synthesized previously in the Spivey research group was tested using the FP assay platform and shown to produce good binding data towards AR. It gave a micromolar level IC50, 18.72 ± 3.94 μM. This promising result provides a strong impetus for further investigation of this type of compound for the modulation of AR activity.
Optimal common mode control for neutral point potential ripple minimization on ANPC converter
Creators: name: Mariéthoz, Sébastien
Publisher: name: IEEE
Year: 2024

description: The paper deals with the minimization of the neutral point ripple on NPC and ANPC converters. The method is based on optimization techniques. It is particularly useful for minimizing the ripple and thus dc-bus requirements on drive systems operating at low and medium fundamental frequency. It is validated in simulation and experimentally for the control of a GaN ANPC converter.
iMADS: A sustainable software collaboration for predicting transcription factor binding specificity
Creators: name: Leehr, Dan
name: Bradley, John
name: Gordan, Raluca
name: Shen, Ning
name: Lapp, Hilmar
Publisher: name: F1000 Research Limited
Year: 2018

description: iMADS (integrative Modeling and Analysis of Differential Specificity) is a combined computational-experimental strategy to identify and study the differences in DNA-binding specificity between transcription factor (TF) family members, i.e. paralogous TFs. In this poster, we present our approach to building a sustainable research software product to promote dissemination, exploration, and impact of the iMADS methods and datasets
Case-control study on associations of hemorrhagic bowel syndrome in swine with feed characteristics and intestinal pathogens
Creators: name: Holenweger, Fabienne
name: Spring, Peter
name: Khayatzadeh, Negar
name: Hofer, Andreas
name: Schüpbach-Regula, Gertraud
name: Grahofer, Alexander
Publisher: name: BioMed Central
Year: 2024

description: Haemorrhagic bowel syndrome (HBS) is one of the most common causes of death in fattening pigs worldwide. The objective of this descriptive study was to systematically assess predictors or causal components for the appearance of HBS using case farms (mortality rate caused by HBS ≥ 1.5%) in comparison with control farms (mortality rate caused by HBS ≤ 0.25%), focusing on feed ingredients, feed quality and size, and gastrointestinal pathogens. The inclusion of sugar beet as a feed component in liquid feeding systems was found to be associated (p = 0.03) with farms identified as HBS cases. Another predictive or causal factor found for liquid feeding systems, but only for those using meal, was particle size. A higher percentage of small particles (< 2 mm) in the meal was associated with a higher risk of being an HBS case farm (p = 0.02), while no relevant association was detected for the use of pellets. Sugar beet in the diet was also associated with the incidence of HBS. The microbial quality of the feed in dry feeding systems, specifically the number of total aerobes at the first and last outlet tubes, was associated with a higher incidence of HBS (p = 0.03). Faecal sample analysis showed a difference (p < 0.05) in the prevalence of B. pilosicoli in the herd category (case vs. control herd). In this descriptive study, five predictive or causal factors were identified for an HBS farm with a mortality rate due to HBS ≥ 1.5%. These included the number of aerobes in dry matter samples from the first and last feeders, the particle diameter of the meal used in liquid feeding systems and sugar beet as a component of liquid feeding rations, and the presence of B. pilosicoli as an infectious agent at animal level. Relevant associations reinforce the findings of the previously published Swiss study that HBS is a multifactorial syndrome involving different aspects of pig production and cannot be attributed to a single cause. Further studies are needed to develop evidenced based causal models for HBS in swine.
Kann uns Künstliche Intelligenz beim Klimaschutz helfen?
Creators: name: Bieser, Jan
Publisher: name: Berner Fachhochschule, Wirtschaft
Year: 2024

description: Die Künstliche Intelligenz (KI) verspricht Wirtschaft und Gesellschaft zu transformieren, und damit zum Klimaschutz beizutragen. Doch trotz über zehn Jahren rasant fortschreitender Digitalisierung bleiben unsere Klimaprobleme ungelöst. Warum sollte dies nun mit KI grundlegend anders sein?
Cellular immunity in adenoids and blood of otitis media-prone children
Creators: name: Browne, Jessica J.
name: Matthews, Evan H.
name: Taylor-Robinson, Andrew W.
name: Jennelle M. Kyd
Publisher: name: F1000 Research Limited
Year: 2018

description: Middle ear infections (otitis media, OM) are a major burden on health services worldwide. More than 80% of children will have suffered with an OM infection by 3 years of age. Of these juveniles, almost 40% will develop recurring infections, with little relief experienced from antibiotic therapies.

This research project aims to improve the understanding of the immune-regulation of OM in children, with a specific focus on the cellular pathways driving immune-suppression and infection tolerance in OM-prone children.

The study described here involves two cohorts of non-OM prone children and OM prone children. Patients scheduled for adenoidectomy due to clinical reasons, including adenoid hypertrophy and OM, were recruited into the study for the collection of their clinical data and tissue samples including adenoids, blood, nasopharyngeal and saliva aspirates. The tissue samples and clinical data were used to determine immune differences between the two cohorts through the analysis of both clinical microbiology and immune cell responses to OM pathogens.

Understanding cellular immune regulation in OM has the potential to identify physiological factors that may be used to influence adenoidectomy, immunotherapy and vaccine treatments for OM. This approach aims to enable children to experience a quicker recovery from infection, possibly avoiding the progression to chronic disease. This would result in an overall improved quality of life due to reduced adverse side effects experienced that are associated with prolonged OM-related disease.
Local Transcription Models in Home Care Nursing in Switzerland: an Interdisciplinary Case Study
Creators: name: Kramer, Jeremy
name: Kravchenko, Tetiana
name: Kaufmann, Beatrice
name: Thilo, Friederike J.S.
name: Kurpicz-Briki, Mascha
Year: 2024
Subjects: cs.CL
nursing
nursing informatics
local transcription
digitalization
digital transformation

description: Latest advances in the field of natural language processing (NLP) enable new use cases for different domains, including the medical sector. In particular, transcription can be used to support automation in the nursing documentation process and give nurses more time to interact with the patients. However, different challenges including (a) data privacy, (b) local languages and dialects, and (c) domain-specific vocabulary need to be addressed. In this case study, we investigate the case of home care nursing documentation in Switzerland. We assessed different transcription tools and models, and conducted several experiments with OpenAI Whisper, involving different variations of German (i.e., dialects, foreign accent) and manually curated example texts by a domain expert of home care nursing. Our results indicate that even the used out-of-the-box model performs sufficiently well to be a good starting point for future research in the field.
Additional file 1 of Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial
Creators: name: Lie, Sole Lindvåg
name: Hisdal, Jonny
name: Rehn, Marius
name: Høiseth, Lars Øivind
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Information Systems not elsewhere classified
subject: Hematology

description: Additional file1. Original protocol.
New insights into one of the oldest glacial deposits in the northern Alpine foreland (Höchsten, SW Germany)
Creators: name: Bamford, Clare A.
name: Pomper, Johannes E.
name: Hergarten, Stefan
name: Preusser, Frank
name: Sprafke, Tobias
name: Gegg, Lukas
Publisher: name: Wiley
Year: 2024
Subjects: Quaternary Geology
Alpine Foreland
glacial deposits
paleosol
geotechnical analyses
Middle Pleistocene

description: The present‐day landscape of the northern Alpine foreland is marked by the cumulated impact of weathering during interglacial, and of erosion and deposition during glacial periods of the Quaternary. Direct traces of the earliest phases of ice advance, as well as thorough studies thereof, exist only sporadically. Here, a succession of diamictic deposits, which has been interpreted as the infill of an Early Pleistocene overdeepened basin, is investigated with a combined sedimentological‐geotechnical approach including analysis via μCT scans, and standard tests of the water uptake, consistency, and compaction properties. The diamicts are exposed along a 4.5‐m‐deep profile, and are subdivided into a yellowish‐brown lower unit with a variable, carbonaceous, silty to sandy matrix, and a reddish‐brown upper unit that is free from carbonate and appears largely homogeneous. Although the lower unit is rather loose and surficially bioturbated, it contains microstructures indicative of subglacial deformation, which are lacking in the compact and clay‐rich upper unit. The lower part is interpreted as a secondary glacial deposit (i.e. it has been affected by limited sorting in water) that was overridden and sheared by a glacier briefly after deposition, and recently bioturbated. The upper part is less sorted, more massive and compact, and thus likely of a primary glacial nature. It is further characterized by a strong pedogenetic overprint typical of prolonged warm periods. This suggests that it is separated from the overlying glacifluvial gravel, which has an equivalent petrographic composition, by a full interglacial at least. Thus, the combination of geotechnical testing and CT‐based micromorphology offers a new, practical and cost‐effective approach to the characterization of glacially derived sediments.
sj-pdf-1-smm-10.1177_09622802231163330 - Supplemental material for Linear mixed models for investigating effect modification in subgroup meta-analysis
Creators: name: Sørensen, Anne Lyngholm
name: Marschner, Ian C
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-smm-10.1177_09622802231163330 for Linear mixed models for investigating effect modification in subgroup meta-analysis by Anne Lyngholm Sørensen and Ian C Marschner in Statistical Methods in Medical Research
Development and evaluation of a web-based diet quality screener for vegans (VEGANScreener): a cross-sectional, observational, multicenter, clinical study
Creators: name: Asif, Tooba
name: Ouřadová, Anna
name: Martínez Tabar, Ainara
name: Bogl, Leonie-Helen
name: Et Al.
Publisher: name: Frontiers Research Foundation
Year: 2024
Subjects: Nutrition
Plant-based diet
Vegan diet
Diet quality
Diet assessment
Diet screener

description: Consumption of plant-based diets, including vegan diets, necessitates attention to the quality of the diet for the prevention and early detection of nutritional deficiencies. Within the VEGANScreener project, a unique brief screening tool for the assessment and monitoring of diet quality among vegans in Europe was developed. To provide a standardized tool for public use, a clinical study will be conducted to evaluate the VEGANScreener against a reference dietary assessment method and nutritional biomarkers. An observational study is set to include 600 participants across five European sites – Belgium, Czech Republic, Germany, Spain, and Switzerland. In total, 400 self-reported vegans (≥2 years on a vegan diet), and 170 self-reported omnivore controls will be examined, aged between 18 and 65 years, with males and females being equally represented in a 1:1 ratio for two age groups (18–35 and 36–65 years). Participants with diseases affecting metabolism and intestinal integrity will be excluded. The clinical assessment will include a structured medical history, along with taking blood pressure and anthropometric measurements. Blood and urine will be sampled and analyzed for a set of dietary biomarkers. Metabolomic analyses will be conducted to explore potential novel biomarkers of vegan diet. Moreover, saliva samples will be collected to assess the metabolome and the microbiome. Participants will receive instructions to complete a nonconsecutive 4-day diet record, along with the VEGANScreener, a socio-demographic survey, a well-being survey, and a FFQ. To evaluate reproducibility, the VEGANScreener will be administered twice over a three-weeks period. Among vegans, the construct validity and criterion validity of the VEGANScreener will be analyzed through associations of the score with nutrient and food group intakes, diet quality scores assessed from the 4-day diet records, and associations with the dietary biomarkers. Secondary outcomes will include analysis of dietary data, metabolomics, and microbiomes in all participants. Major nutrient sources and variations will be assessed in the sample. Exploratory metabolomic analysis will be performed using multivariable statistics and regression analysis to identify novel biomarkers. Standard statistical models will be implemented for cross-sectional comparisons of geographical groups and vegans versus omnivores.
Wirkung von Subventionen auf die Biodiversität: Evaluation von Erschliessungsbeiträgen ausserhalb Schutzwald und forstlicher Investitionskredite: Studie im Auftrag des Bundesamts für Umwelt (BAFU)
Creators: name: Coleman Brantschen, Evelyn Constance
name: Thür, Peter
name: Waeber, Patrick Olivier
Publisher: name: Berner Fachhochschule, Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften HAFL
Year: 2024

description: Die Strategie Biodiversität Schweiz enthält die Massnahme 4.2.4 "Evaluation der Wirkung von Bundessubventionen", welche vorgibt, dass der Bund bis 2023 eine Gesamtevaluation zu den Auswirkungen der Bundessubventionen und weiterer Anreize mit Folgen für die Biodiversität vorzulegen hat. In einer Vorstudie wurde, gestützt auf einen Bericht "Biodiversitätsschädigende Subventionen" (Gubler et al. 2020), unter anderem empfohlen, die folgenden zwei Instrumente bezüglich ihrer Wirkung auf die Biodiversität vertiefend zu betrachten: 1) Programmvereinbarung Wald, Teilprogramm Waldbewirtschaftung, mit Fokus auf die Walderschliessung ausserhalb des Schutzwaldes; 2) Forstliche Investitionskredite (rückzahlbare Darlehen). Ziel des vorliegenden Auftrags ist eine formative Evaluation dieser zwei Subventionskategorien und deren Wirkung auf die Biodiversität, auf Ebene von Bund und Kantonen. Daraus sollen Empfehlungen für eine Vermeidung deren biodiversitätsschädigender Wirkungen abgeleitet werden. Forschungsfragen sind: - Welche sind die möglichen Wirkungen der finanziellen Beiträge für Erschliessungen ausserhalb Schutzwald und der gewährten Investitionskredite auf die Biodiversität? - Welche Rahmenbedingungen, Vorgaben und Vorgehensweisen gelten heute auf Bundes- und Kantonsebene, welche eine Wirkung auf die Biodiversität haben können? - Welche Empfehlungen können formuliert werden, um eine biodiversitätsschädigende Wirkung von Beiträgen zu vermeiden?
“Once upon a time” Performative ultra-conceptualism and storytelling as conservation—Florence Jung
Creators: name: Hölling, Hanna Barbara
Publisher: name: Routledge
Year: 2024
Subjects: Storytelling
Florence Jung
Performance
Conservation
Materiality
Knowledge

description: Artist Florence Jung eschews the label of ‘performance art’ and deliberately avoids personal presence in her works. She creates situations that embody uncertainty and instability, seeking to cultivate inclusivity and engage everyone in the experiences she constructs. Her works often lack tangible elements and documentation, blurring the lines between staged events and reality, leading to narratives and rumors as the primary means by which her art endures. This essay explores Jung’s performative ultra-conceptualism and her choice not to personally document her works, instead emphasizing storytelling as a means of survival for her context-driven art. From a conservation and collections perspective, the essay raises questions about how to handle her unconventional works, which often exist in the realm of thoughts, shifting contexts, and oral transmission—much like, or perhaps even further elucidating, the logic of ‘traditional’ performance. Ultimately, it argues that Jung’s performative ultra-conceptualism, rooted in invisibility and intangibility, can be conveyed through storytelling and rumors, offering a unique way to experience and preserve them.
Additional file 5 of Media exposure to climate change information and pro-environmental behavior: the role of climate change risk judgment
Creators: name: Vrselja, Ivana
name: Pandžić, Mario
name: Rihtarić, Martina Lotar
name: Ojala, Maria
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 5
AIE: Auction Information Enhanced Framework for CTR Prediction in Online Advertising
Creators: name: Yang, Yang
name: Chen, Bo
name: Zhu, Chenxu
name: Zhu, Menghui
name: Dai, Xinyi
name: Guo, Huifeng
name: Zhang, Muyu
name: Dong, Zhenhua
name: Tang, Ruiming
Publisher: name: arXiv
Year: 2024
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Click-Through Rate (CTR) prediction is a fundamental technique for online advertising recommendation and the complex online competitive auction process also brings many difficulties to CTR optimization. Recent studies have shown that introducing posterior auction information contributes to the performance of CTR prediction. However, existing work doesn't fully capitalize on the benefits of auction information and overlooks the data bias brought by the auction, leading to biased and suboptimal results. To address these limitations, we propose Auction Information Enhanced Framework (AIE) for CTR prediction in online advertising, which delves into the problem of insufficient utilization of auction signals and first reveals the auction bias. Specifically, AIE introduces two pluggable modules, namely Adaptive Market-price Auxiliary Module (AM2) and Bid Calibration Module (BCM), which work collaboratively to excavate the posterior auction signals better and enhance the performance of CTR prediction. Furthermore, the two proposed modules are lightweight, model-agnostic, and friendly to inference latency. Extensive experiments are conducted on a public dataset and an industrial dataset to demonstrate the effectiveness and compatibility of AIE. Besides, a one-month online A/B test in a large-scale advertising platform shows that AIE improves the base model by 5.76% and 2.44% in terms of eCPM and CTR, respectively.
Ein Notariats-Protokoll von 1638 bis 1640 über Reliquien-Erhebungen aus den römischen Katakomben
Creators: name: Lüdtke, Willy
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 23 Nr. 1 (1909): Römische Quartalschrift, Band 23, Heft 1
Supplemental Material - Attachment and Maladjustment: The Role of Effortful Control Development During Middle Childhood
Creators: name: Heylen, Joke
name: Budniok, Samuel
name: Van de Walle, Magali
name: De Raedt, Rudi
name: Bijttebier, Patricia
name: De Winter, Simon
name: Bosmans, Guy
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 160301 Family and Household Studies
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material for Attachment and Maladjustment: The Role of Effortful Control Development During Middle Childhood by Joke Heylen, Samuel Budniok, Magali Van de Walle, Rudi De Raedt, Patricia Bijttebier, Simon De Winter, and Guy Bosmans in The Journal of Early Adolescence
Adaptive gait responses to varying weight-bearing conditions: Inferences from gait dynamics and H-reflex magnitude
Creators: name: Kim, Yong Kuk
name: Gwerder, Michelle
name: Taylor, William R.
name: Baur, Heiner
name: Singh, Navrag B.
Publisher: name: Wiley
Year: 2024

description: This study investigates the effects of varying loading conditions on excitability in neural pathways and gait dynamics. We focussed on evaluating the magnitude of the Hoffman reflex (H-reflex), a neurophysiological measure representing the capability to activate motor neurons and the timing and placement of the foot during walking. We hypothesized that weight manipulation would alter H-reflex magnitude, footfall and lower body kinematics. Twenty healthy participants were recruited and subjected to various weight-loading conditions. The H-reflex, evoked by stimulating the tibial nerve, was assessed from the dominant leg during walking. Gait was evaluated under five conditions: body weight, 20% and 40% additional body weight, and 20% and 40% reduced body weight (via a harness). Participants walked barefoot on a treadmill under each condition, and the timing of electrical stimulation was set during the stance phase shortly after the heel strike. Results show that different weight-loading conditions significantly impact the timing and placement of the foot and gait stability. Weight reduction led to a 25% decrease in double limb support time and an 11% narrowing of step width, while weight addition resulted in an increase of 9% in step width compared to body weight condition. Furthermore, swing time variability was higher for both the extreme weight conditions, while the H-reflex reduced to about 45% between the extreme conditions. Finally, the H-reflex showed significant main effects on variability of both stance and swing phases, indicating that muscle-motor excitability might serve as feedback for enhanced regulation of gait dynamics under challenging conditions.
Additional file 1 of The relationship between openness and social anxiety: the chain mediating roles of social networking site use and self-evaluation
Creators: name: Gong, Jian
name: Li, Ye
name: Niu, Bingyu
name: Liu, Xiaofei
name: Wang, Yuyan
name: Zhou, Bingping
name: Hai, Man
Publisher: name: figshare
Year: 2024
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Additional file 1.
sj-docx-2-srd-10.1177_23780231231160640 – Supplemental material for Visualizing Underemployment Dynamics in Australia: Combining Sankey and Sequence Analysis Plots
Creators: name: Fauser, Sophia
name: Mooi-Reci, Irma
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-2-srd-10.1177_23780231231160640 for Visualizing Underemployment Dynamics in Australia: Combining Sankey and Sequence Analysis Plots by Sophia Fauser and Irma Mooi-Reci in Socius
HKB-Zeitung. Ordnungssysteme
Creators: name: Pauli, Christian
name: Doering, Dörte
name: Whitebread, Kate
name: Gubler, Rico Max
name: Schoon, Andi
name: Mekacher, Nina
name: Lunn, Felicity
name: Matt Robert, Sibylle
name: Gartmann, Thomas
name: Achtnich, Leonie
name: Gisler, Priska
name: Scheller, Katharina
name: Kilchenmann, Marc
name: Bacciagaluppi, Claudio
name: Butz, Heinrich
name: Horst, Maria
name: Bader, Eva
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2024
Subjects: Ordungssysteme

description: Kunst stellt man sich gerne als kreative Unordnung vor. «Genau dort Klarheit zu schaffen, wo es am wenigsten Sinn macht», behauptete die erfolgreiche Buchreihe Kunst aufräumen und bedient damit ein wunderbar funktionierendes Klischee. Dabei verlangt die Kunst zunächst das Gegenteil: aufgeräumte Gedanken in aufgeräumten Räumen. Das Bedürfnis nach Ordnung und sauberen Systemen beschäftigt die ganze Gesellschaft. Der globale-mediale Mensch denkt sich gerne Role Models aus: Neuerdings helfen Cleanfluencer als Ordnungsexpert* innen, im täglichen Chaos den Überblick nicht zu verlieren. Die zeitgenössische Debatte dreht sich aber auch um reale Verhältnisse zwischen Ordnungssystemen, Organisation, Kontrolle, dem Teilen von Wissen und Fragen danach, welche Rolle und Funktion Menschen hier einnehmen können. Im Bereich Kunst heisst das, Konventionen, Kenntnisse über deren Wirkungsweisen zu hinterfragen. Die HKB-Zeitung hinter- und erfragt die Ordnungssysteme in der Kunst und in der Kunstausbildung. Dabei blicken wir von der HKB, der Kunstausbildung, in die weite Gesellschaft hinaus: Wie geht die Lehre mit den zu vermittelnden Ordnungssystemen um? Wie halten es die Disziplinen, Genres und hochschulmässig die Fachbereiche mit der Ordnung? Was unterscheidet das Ordnungsdenken in der Kunst von jenem der Wissenschaft? Inspiriert ist der Schwerpunkt dieser HKB-Zeitung von Paul Feyerabend, der vor hundert Jahren geboren wurde. Der österreichische Starphilosoph – 1975 erschien sein berühmtestes Werk Wider den Methodenzwang – hinterfragte mit Furor das Ordnungssystem Wissenschaft und richtete seinen Blick dabei gerne auch auf die Kunst. Das tun wir hier auch: Der Wissenschaftsjournalist und Kurator Roland Fischer schreibt einen Essay über Feyerabends Pluralismus. Kunsthistorikerin Stefanie Manthey reflektiert über künstlerische Umordnungen. HKB-Dozent*innen und -Forscher*innen denken über die Ordnungssysteme Zoologie, Kartografie, Anarchismus, Bibliothek und Politik nach. Abrunden tut das Thema eine Runde mit den Gedanken und Bürotischen der Fachbereichsleiter*innen der HKB. Illustriert ist diese Ausgabe der HKB-Zeitung mit Fotos von HKBAlumnus Tim Rod. In seiner Bachelorthesis Fragmente der Erinnerung befasst er sich mit der Ordnung von Erinnerungen. Auf der Suche nach Kriterien und Systemen entsteht eine beeindruckende Bildstrecke, die dazu einlädt, Gemeinsamkeiten zu entdecken. Schliesslich spielen wir im Layout der HKB-Zeitung Textordnungen durch. Lassen Sie sich überraschen von vielfältigen Ordnungen, Unordnungen und Umordnungen. (Editorial, Christian Pauli)
title: "Statua di fanciullo ammantato", Arte romana, inv. LXV (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Ciccarello, Giulia
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Stephan Beissel, Entstehung der Perikopen des Römischen Messbuches
Creators: name: Müller-Ravensburg, Alfons
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 22 Nr. 2 (1908): Römische Quartalschrift, Band 22, Heft 2