cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Atheta (Pseudota) klagesi Bernhauer 1909
Creators: name: Klimaszewski, Jan
name: Chandler, Donald S.
name: Davies, Anthony
name: Bourdon, Caroline
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Atheta
Atheta klagesi

description: 49. Atheta (Pseudota) klagesi Bernhauer
(Illustrations in Klimaszewski et al. 2018), Table 1
References. Bernhauer 1909. Gusarov 2003. Webster et al. 2016. Klimaszewski et al. 2016 a,c,d, 2018. Brunke et al. 2021.
Distribution. Nearctic. Canada: AB, MB, NB, NF, QC. USA: ME, NH (NSR), PA.
Collection and Habitat data. The NH specimens were captured from May to October by FITs, by sifting forest litter by streams, in leaf litter at birch sap drip, and in rotten wood. Also found by examining Russula mushrooms and a mass of mushrooms on a large stump. In Canada found in a variety of coniferous and deciduous forests. Adults were taken in various fungi, including fleshy polypore fungi, inside birch polypore (Piptoporus betulinus (Bull.) Karst.), gilled mushrooms, decaying coral fungi, and in a well-rotted fungus covered log. Some were found in compost (moldy corncobs and cornhusks, decaying vegetables). In NL specimens were obtained from pitfall traps in boreal conifer forests (Klimaszewski et al. 2018).
Material. USA, New Hampshire, Carroll Co.: 2 mi NW Jackson, 11.IX.1981, D.S. Chandler, berlese forest litter, 6 males, 1 female. Coos Co.: 1 mi NE East Inlet Dam, 12–24.VI.1986, D.S. Chandler, FIT, 1 male. Norton Pool, 3 mi NE East Inlet Dam, 27.V–11.VI.1986, D.S. Chandler, FIT, 1 male. Coos Co.: 8 mi E Gorham, 800’, 14.VIII.1976, J.M. and B.A. Campbell (CNC), 1 female, 1 sex? 17 km S Gorham, Glen Ellis Falls, 1900’, 8.IX.1987, J.M. Campbell and A. Davies, sifting litter by stream (CNC), 1 sex? Hwy 16, 5.6 km S Gorham, 9.IX.1987, A. Smetana (CNC), 5 males, 2 females, 31 sex? 6 mi NW Bartlett, Nancy Brook Trail, 1500’, 9.IX.1987, A. Davies and Y. Bousquet, ex. Russula mushrooms (CNC), 5 sex? 2 mi NE Crawford Depot, 2100’, 13.IX.1987, J.M. Campbell and A. Davies, ex. mass of mushrooms on large stump (CNC), 3 females, 21 sex? Grafton Co.: Hubbard Brook Exp. Forest, Bear Brook, 1500’, 15.X.1982, D.S. Chandler, sift rotten wood, 1 male, 1 female. Strafford Co.: 1 mi SW Durham, 21.V.1982, D.S. Chandler, sift leaf litter birch sap drip, 1 male.
description: Published as part of Klimaszewski, Jan, Chandler, Donald S., Davies, Anthony & Bourdon, Caroline, 2023, Aleocharine rove beetles of New Hampshire, USA: new taxa and new records (Coleoptera, Staphylinidae, Aleocharinae), pp. 1-141 in Zootaxa 5364 (1) on page 30, DOI: 10.11646/zootaxa.5364.1.1, http://zenodo.org/record/10145460
Impact of route of access and stenosis subtype on outcome after transcatheter aortic valve replacement
Creators: name: Maier, Julian
name: Lambert, Thomas
name: Senoner, Thomas
name: Dobner, Stephan
name: Hoppe, Uta Caroline
name: Fellner, Alexander
name: Pfeifer, Bernhard Erich
name: Feuchtner, Gudrun Maria
name: Friedrich, Guy
name: Semsroth, Severin
name: Bonaros, Nikolaos
name: Holfeld, Johannes
name: Müller, Silvana
name: Reinthaler, Markus
name: Steinwender, Clemens
name: Barbieri, Fabian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: low-flow low-gradient aortic stenosis
subject: transcatheter aortic valve implantation
subject: transcatheter aortic valve replacement
subject: access route
subject: transapical access
subject: transfemoral access
subject: high gradient aortic stenosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Previous analyses have reported the outcomes of transcatheter aortic valve replacement (TAVR) for patients with low-flow, low-gradient (LFLG) aortic stenosis (AS), without stratifying according to the route of access. Differences in mortality rates among access routes have been established for high-gradient (HG) patients and hypothesized to be even more pronounced in LFLG AS patients. This study aims to compare the outcomes of patients with LFLG or HG AS following transfemoral (TF) or transapical (TA) TAVR. Methods: A total of 910 patients, who underwent either TF or TA TAVR with a median follow-up of 2.22 (IQR: 1.22-4.03) years, were included in this multicenter cohort study. In total, 146 patients (16.04%) suffered from LFLG AS. The patients with HG and LFLG AS were stratified according to the route of access and compared statistically. Results: The operative mortality rates of patients with HG and LFLG were found to be comparable following TF access. The operative mortality rate was significantly increased for patients who underwent TA access [odds ratio (OR): 2.91 (1.54-5.48), p = 0.001] and patients with LFLG AS [OR: 2.27 (1.13-4.56), p = 0.02], which could be corroborated in a propensity score-matched subanalysis. The observed increase in the risk of operative mortality demonstrated an additive effect [OR for TA LFLG: 5.45 (2.35-12.62), p < 0.001]. LFLG patients who underwent TA access had significantly higher operative mortality rates (17.78%) compared with TF LFLG (3.96%, p = 0.016) and TA HG patients (6.36%, p = 0.024). Conclusions: HG patients experienced a twofold increase in operative mortality rates following TA compared with TF access, while LFLG patients had a fivefold increase in operative mortality rates. TA TAVR appears suboptimal for patients with LFLG AS. Prospective studies should be conducted to evaluate alternative options in cases where TF is not possible.
Mutational Analysis of RIP Type I Dianthin-30 Suggests a Role for Arg24 in Endocytosis
Creators: name: Schlaak, Louisa
name: Weise, Christoph
name: Kuropka, Benno
name: Weng, Alexander
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: ribosome-inactivating proteins
subject: type I RIP
subject: N-glycosylase
subject: triterpene saponins
subject: endosomal escape enhancer
subject: basic amino acid residues
subject: endocytosis
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Saponin-mediated endosomal escape is a mechanism that increases the cytotoxicity of type I ribosome-inactivating proteins (type I RIPs). In order to actualize their cytotoxicity, type I RIPs must be released into the cytosol after endocytosis. Without release from the endosomes, type I RIPs are largely degraded and cannot exert their cytotoxic effects. Certain triterpene saponins are able to induce the endosomal escape of these type I RIPs, thus increasing their cytotoxicity. However, the molecular mechanism underlying the endosomal escape enhancement of type I RIPs by triterpene saponins has not been fully elucidated. In this report, we investigate the involvement of the basic amino acid residues of dianthin-30, a type I RIP isolated from the plant Dianthus caryophyllus L., in endosomal escape enhancement using alanine scanning. Therefore, we designed 19 alanine mutants of dianthin-30. Each mutant was combined with SO1861, a triterpene saponin isolated from the roots of Saponaria officinalis L., and subjected to a cytotoxicity screening in Neuro-2A cells. Cytotoxic screening revealed that dianthin-30 mutants with lysine substitutions did not impair the endosomal escape enhancement. There was one particular mutant dianthin, Arg24Ala, that exhibited significantly reduced synergistic cytotoxicity in three mammalian cell lines. However, this reduction was not based on an altered interaction with SO1861. It was, rather, due to the impaired endocytosis of dianthin Arg24Ala into the cells.
Case Report: Successful endovascular treatment of acute type A aortic dissection
Creators: name: Pitts, Leonard
name: Heck, Roland
name: Montagner, Matteo
name: Penkalla, Adam
name: Kofler, Markus
name: Falk, Volkmar
name: Kempfert, Jörg
name: Buz, Semih
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: aortic dissection
subject: type A
subject: TEVAR
subject: endovascular
subject: ascending aorta
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Open surgical repair remains the current gold standard for the treatment of acute type A aortic dissection. However, especially elderly patients with relevant comorbidities who are deemed unfit for open surgery may benefit from a minimally invasive endovascular approach. Methods: We report a case of an 80-year-old male with retrograde acute type A aortic dissection and peripheral malperfusion after receiving thoracic endovascular aortic repair due to thoracic aortic aneurysm. Our individualized endovascular approach consisted of left carotid-subclavian bypass, proximal extension of thoracic endovascular aortic repair using a covered stent graft and a single covered stent graft for the ascending aorta in combination with an uncovered stent for the aortic arch. Results: Postoperative computed tomographic angiography demonstrated excellent outcome with no signs of endoleak or patent false lumen. Follow-up after 3.5 years showed a stable result with no signs of stent failure or dissection progress. No aortic re-interventions were needed in the further course. Discussion: An individualized endovascular approach may be justified for acute type A aortic dissection in elderly patients with high surgical risk if performed in specialized aortic centers. Additional short-length stent graft devices are needed to address the anatomical challenges of the ascending aorta. For enhanced remodeling of the dissected aorta, the use of an additional uncovered stent may be advisable.
Impact of Artisanal Gold Mining in Community Conserved Areas with High Biodiversity Using a Multi-Criteria Approach: A Case Study in Colombia
Creators: name: Gomez, Franco Hernan
name: Pelegri, Natalia
name: Lopez, Juan Guillermo
name: Torres, Kelly Cristina
name: Vaccari, Mentore
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: deforestation
subject: biodiversity
subject: polluted waters
subject: mercury
subject: multi-criteria analysis
subject: ASGM
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::577 Ökologie

description: Artisanal small-scale gold mining (ASGM) using mercury affects community agreements for the conservation of forests (CoS) and lakes (CoH), which have a high level of biodiversity in the Peasant Reserve Zone of the Cimitarra River Valley (ZRC-VRC) in Colombia. In this research, a multi-criteria approach (MCA) was applied to analyze the impact of ASGM. This analysis is based on the community environmental agreements to preserve CoS and CoH areas, the ecological importance of these areas, as well as the results of mercury dispersion in the Cimitarra river basin, with concentrations found 40 km downstream of the mining area of 0.09 µgTHg L−1 in the Cimitarra river, 0.07 µgTHg L−1 in the CoH, and 0.01 mgTHg kg−1 in the tissues of macrophytes, as well as the increase in deforestation since 2020 in the CoS, due to a 1.8% (990 ha) loss of forest cover, with 693 ha of the forest cover loss coinciding with areas related to the opening of new mines. The MCA showed that the main impact is found within the criterion Social and armed conflict, followed by Deforestation. This research offers recommendations to reduce impact scores, such as the implementation of a sustainable development plan (PDS) of the ZRC-VRC, and it highlights the urgent need to safeguard the community conservation areas.
Biological studies of organellar (Na⁺,K⁺)/H⁺ exchanger NHE7
Creators: name: Lin, Paulo J. C.
Publisher: name: University of British Columbia
Year: 2008

description: Cellular pH homeostasis plays crucial roles in cellular functions, and it is now widely recognized that Na⁺/H⁺ exchangers are among the most prominent players in this process. Although recently described mammalian Na⁺/H⁺ exchanger NHE7 has attracted much attention, its biological functions remain largely unknown. Most proteins exist as protein complexes in the cell and elicit their unique functions in collaboration with their binding partners. Therefore, identification and characterization of binding proteins will often unveil unexpected functions of the protein of interest. To begin to elucidate biological roles of the novel class of Na⁺/H⁺ exchanger NHE7, yeast two-hybrid screening was conducted and several binding candidates were identified. Among these candidates, I show that Secretory Carrier Membrane Proteins (SCAMPs) are novel NHE7 binding proteins and that SCAMPs regulate endocytic trafficking of NHE7 from the recycling endosomes to the trans-Golgi network (TGN). In agreement with this finding, I found that NHE7 can also be targeted to the plasma membrane and then internalized. Caveolins, structural proteins for caveolae, were identified as NHE7-binding proteins and it was initially hypothesized that caveolins might regulate NHE7-internalization. Interestingly, caveolins bound to NHE7 through a novel binding domain and facilitated its association to caveolae/lipid rafts, but did not affect NHE7-internalization. I also show that SCAMP2 associates with the heterotrimeric G protein β subunit (Gβ) and regulates the ERK1/2 signaling. Moreover, NHE7 was found to associate with both SCAMP2 and Gβ in the cell, suggesting that ERK1/2 signaling mediated by the SCAMP2-Gβ complex might regulate NHE7.
Atheta (Dimetrota) lindrothides Newton
Creators: name: Klimaszewski, Jan
name: Chandler, Donald S.
name: Davies, Anthony
name: Bourdon, Caroline
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Atheta
Atheta lindrothides

description: 50. Atheta (Dimetrota) lindrothides Newton
(Illustrations in Klimaszewski et al. 2011, 2018), Table 1
References. Klimaszewski et al. 2011, 2018. Newton 2017.
Distribution. Nearctic. Canada: NF. USA (NCR): NH (NSR).
Collection and Habitat data. No habitat data available for the NH specimen; the male was captured in April. In Canada (NF): no habitat available.
Material. USA, New Hampshire, Rockingham Co.: Hampton, 20.IV.1926, S. A. Shaw, 1 male.
Comments. A poorly known species in both NF and NH.
description: Published as part of Klimaszewski, Jan, Chandler, Donald S., Davies, Anthony & Bourdon, Caroline, 2023, Aleocharine rove beetles of New Hampshire, USA: new taxa and new records (Coleoptera, Staphylinidae, Aleocharinae), pp. 1-141 in Zootaxa 5364 (1) on page 31, DOI: 10.11646/zootaxa.5364.1.1, http://zenodo.org/record/10145460
Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector
Creators: name: Zanker, Jeanette
name: Hüser, Daniela
name: Savy, Adrien
name: Lázaro-Petri, Sara
name: Hammer, Eva-Maria
name: Schwarzer, Christoph
name: Heilbronn, Regine
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: adeno-associated virus
subject: gene therapy
subject: neuropeptide
subject: SH-SY5Y
subject: differentiation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, in vitro testing of vector-derived transgene function can be challenging when specific post-translational modifications are needed for biological activity. Similarly, neuropeptide precursors need to be processed to yield mature neuropeptides. SH-SY5Y is a human neuroblastoma cell line commonly used due to its ability to differentiate into specific neuronal subtypes. In this study, we evaluate the suitability of SH-SY5Y cells in a potency assay for neuropeptide-expressing adeno-associated virus (AAV) vectors. We looked at the impact of neuronal differentiation and compared single-stranded (ss) AAV and self-complementary (sc) AAV transduction at increasing MOIs, RNA transcription kinetics, as well as protein expression and mature neuropeptide production. SH-SY5Y cells proved highly transducible with AAV1 already at low MOIs in the undifferentiated state and even better after neuronal differentiation. Readouts were GFP or neuropeptide mRNA expression. Production of mature neuropeptides was poor in undifferentiated cells. By contrast, differentiated cells produced and sequestered mature neuropeptides into the medium in a MOI-dependent manner.
Atheta (Pseudota) longiclava
Creators: name: Klimaszewski, Jan
name: Chandler, Donald S.
name: Davies, Anthony
name: Bourdon, Caroline
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Atheta
Atheta longiclava

description: 51. Atheta (Pseudota) longiclava (Casey)
(Illustrations in Klimaszewski et al. 2018), Table 1
References. Casey 1910. Ashe and Gusarov 2004. Brunke et al. 2012 (misidentified as Atheta nescia (Casey)). Klimaszewski et al. 2018, 2021.
Distribution. Nearctic, reported from A/S (Klimaszewski et al. 2021). Canada: LB, MB, ON, QC. USA: ME (NSR), RI.
Collection and Habitat data. In ME a female was captured by a FIT in late October/early November in a mixed secondary forest. In Canada specimens were taken in sparsly treed open habitats, including an oak savanah/ alvar, a savanah, and an agricultural hadgerow (Brunke et al. 2012, Klimaszewski et al. 2021).
Material. USA, Maine, York Co.: West Lebanon, 30.X–5.XI.1990, D.W. Barry, FIT, 1 female.
Comments. This species was not reported from NH, where it must be present.
description: Published as part of Klimaszewski, Jan, Chandler, Donald S., Davies, Anthony & Bourdon, Caroline, 2023, Aleocharine rove beetles of New Hampshire, USA: new taxa and new records (Coleoptera, Staphylinidae, Aleocharinae), pp. 1-141 in Zootaxa 5364 (1) on page 31, DOI: 10.11646/zootaxa.5364.1.1, http://zenodo.org/record/10145460
Atheta (Chaetida) longicornis
Creators: name: Klimaszewski, Jan
name: Chandler, Donald S.
name: Davies, Anthony
name: Bourdon, Caroline
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Atheta
Atheta longicornis

description: 52. Atheta (Chaetida) longicornis (Gravenhorst) †
(Illustrations in Klimaszewski et al. 2007 a, 2018), Table 1
References. Gravenhorst 1802. Muona 1984. Klimaszewski et al. 2007a, 2013 a, 2018, 2021. Majka and Klimaszewski 2008. Webster et al. 2009. Michaud et al. 2010.
Distribution. Palearctic, adventive in North America. Canada: BC, NB, NF, NS, QC, SK. USA: CA, MN, ME (NSR), NH (NSR), OR.
Collection and Habitat data. The NH specimens were found in coastal backdunes, pig dung in pasture, and taken by FIT, window, and UV light traps. Collected from June to July. In Canada found in open habitats where it occurs in cow and horse dung, carrion, compost, rotting mushrooms, and other rotting organic substrates (Klimaszewski et al. 2018). Some flying individuals were collected with an aerial net in late afternoon (15:00–18:00 h) in early spring in a mixed forest opening (Webster et al. 2009).
Material. USA, Maine, York Co.: West Lebanon, 5–9.VII.1990, D.W. Barry, FIT, 1 male. New Hampshire, Carroll Co.: The Bowl, 2.5 mi NW Wonalancet, 8–14.VI.1984, D.S. Chandler, window trap, 1 female. Rockingham Co.: Seabrook backdunes, 12.VII.1989, D.S. Chandler, UV light, 1 female. 2 mi SE Epping, 31.VII.1986, S.C. Sherman, farm, pig dung in pasture, 1 male, 1 female.
description: Published as part of Klimaszewski, Jan, Chandler, Donald S., Davies, Anthony & Bourdon, Caroline, 2023, Aleocharine rove beetles of New Hampshire, USA: new taxa and new records (Coleoptera, Staphylinidae, Aleocharinae), pp. 1-141 in Zootaxa 5364 (1) on page 31, DOI: 10.11646/zootaxa.5364.1.1, http://zenodo.org/record/10145460
Africonus curralensis
Creators: name: Tenorio, Manuel J.
name: Abalde, Samuel
name: Pardos-Blas, José R.
name: Zardoya, Rafael
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neogastropoda
Conidae
Africonus
Africonus curralensis

description: Africonus curralensis (Rolán, 1986)
Figs 3J, 5K
Conus curralensis Rolán, 1986: 10, fig. 1B.
Conus curralensis – Monteiro et al. 2004: 36, pl. 86.
Conus decoratus form D (not C. decoratus Röckel, Rolán & Monteiro, 1980) – Röckel et al. 1980a: 63, pl. 2, row 2a–b, figs 30(4), 33.
Material examined
Holotype
CABO VERDE • 17 mm; Santa Luzia Island, Curral; 1–3 m depth; E. Rolán leg.; MNCN 15.05/1010 (Fig. 3J).
Other material
CABO VERDE • 1 spec., 23 mm; Santa Luzia Island, Curral; 16º46ʹ23ʺ N, 24º47ʹ13ʺ W; 14 Apr. 2016; MNCN exped.; GenBank mitochondrion, partial genome: MT240806; MNCN 15.05/78591 (Fig. 5K).
Geographical distribution
Southwest coast of Santa Luzia Island, Cabo Verde Archipelago.
Conservation status in IUCN Red List
Near threatened.
Remarks
It was initially reported in Röckel et al. (1980a) as Conus decoratus form D. In the phylogenetic tree, it belongs to the same clade as A. decoratus, but appears only distantly related. A distinctive color form living sympatrically in Santa Luzia Island was initially confused with this species in Abalde et al. (2017a). The sequencing of a specimen fully matching the holotype of A. curralensis has shown that the alleged color form is actually a separate, sister species that is introduced hereby with the name Africonus insulae sp. nov. (see below).
description: Published as part of Tenorio, Manuel J., Abalde, Samuel, Pardos-Blas, José R. & Zardoya, Rafael, 2020, Taxonomic revision of West African cone snails (Gastropoda: Conidae) based upon mitogenomic studies: implications for conservation, pp. 1-89 in European Journal of Taxonomy 663 (663) on pages 18-19, DOI: 10.5852/ejt.2020.663, http://zenodo.org/record/3890442
Disruptive Factors in Product Portfolio Management: An Exploratory Study in B2B Manufacturing for Sustainable Transition
Creators: name: Gramberg, Till
name: Bauernhansl, Thomas
name: Eggert, Andreas
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: product portfolio management
subject: disruption
subject: digitalization
subject: sustainability
subject: servitization
subject: generative artificial intelligence
subject: decision-making
subject: value-oriented
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: Business-to-business (B2B) manufacturing companies are increasingly confronted with transformative trends such as sustainability, digitalization, and servitization. These trends are changing how product portfolios are developed, and how value contributions are assessed, and therefore have disruptive potential. Dealing with these disruptive factors in Product Portfolio Management (PPM) is a largely unexplored topic. This study presents an empirical-qualitative exploration that contributes significantly to the field. The aim is to clarify the extent to which disruptive factors influence the evaluation and shaping of the product portfolio in B2B manufacturing companies. The Gioia method was used to evaluate 21 semi-structured interviews with experts from leading B2B manufacturing companies. Eight overarching challenges in PPM resulting from disruptive factors were identified. Based on the eight overarching challenges and their associated causal relationships, two aggregated dimensions of action were derived: (1) increasing speed and flexibility by using generative artificial intelligence (AI) in a defined PPM process and (2) adjusting the product portfolio evaluation to consider various strategic drivers. These two dimensions of action call for future research to overcome the disruptive factors in PPM.
The Role of Deposition of Cosmogenic 10Be for the Detectability of Solar Proton Events
Creators: name: Schaar, Konstantin
name: Spiegl, Tobias
name: Langematz, Ulrike
name: Sato, T.
name: Mekhaldi, F.
name: Kunze, M.
name: Miyake, F.
name: Yoden, S.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: radionuclide beryllium-10
subject: galactic cosmic rays
subject: atmospheric transport and deposition
subject: detectability of solar proton events
subject: climate model study
subject: ice core data
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften

description: The manifestation of extreme solar proton events (SPEs) in Beryllium-10 (10Be) ice core data contains valuable information about the strength and incidence of SPEs or local characteristics of the atmosphere. To extract this information, the signals of enhanced production of cosmogenic 10Be due to the SPEs have to be detected, hence distinguished from the variability of the background production by galactic cosmic rays (GCRs). Here, we study the transport and deposition of 10Be from GCRs, using the ECHAM/MESSy Atmospheric Chemistry climate model, and discuss the detectability of extreme SPEs (similar to the CE 774/775 SPE) in 10Be ice core data depending on the ice core location, seasonal appearance of the SPE, atmospheric aerosol size distribution and phase of the 11-year solar cycle. We find that sedimentation can be a major deposition mechanism of GCR generated 10Be, especially at high latitudes, depending on the aerosols to which 10Be attaches after production. The comparison of our results to four ice core records of 10Be from Greenland and Antarctica shows good agreement for both 10Be from GCRs and solar energetic particles (SEP). From our results we deduce that the location of detection and the season of occurrence of the SPE have a considerable effect on its detectability, as well as the aerosol size distribution the produced cosmogenic nuclides meet in the atmosphere. Furthermore, we find that SPEs occurring in the phase of highest activity during the 11-year solar cycle are more detectable than SPEs that arise in the phase of lowest activity.
Rift Valley Fever Phlebovirus Reassortment Study in Sheep
Creators: name: Balaraman, Velmurugan
name: Indran, Sabarish V.
name: Kim, In Joong
name: Trujillo, Jessie D.
name: Meekins, David A.
name: Shivanna, Vinay
name: Zajac, Michelle D.
name: Urbaniak, Kinga
name: Morozov, Igor
name: Sunwoo, Sun-Young
name: Faburay, Bonto
name: Osterrieder, Klaus
name: Gaudreault, Natasha N.
name: Wilson, William C.
name: Richt, Juergen A.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Rift Valley fever phlebovirus
subject: bunyavirus
subject: sheep
subject: reassortment
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Rift Valley fever (RVF) in ungulates and humans is caused by a mosquito-borne RVF phlebovirus (RVFV). Live attenuated vaccines are used in livestock (sheep and cattle) to control RVF in endemic regions during outbreaks. The ability of two or more different RVFV strains to reassort when co-infecting a host cell is a significant veterinary and public health concern due to the potential emergence of newly reassorted viruses, since reassortment of RVFVs has been documented in nature and in experimental infection studies. Due to the very limited information regarding the frequency and dynamics of RVFV reassortment, we evaluated the efficiency of RVFV reassortment in sheep, a natural host for this zoonotic pathogen. Co-infection experiments were performed, first in vitro in sheep-derived cells, and subsequently in vivo in sheep. Two RVFV co-infection groups were evaluated: group I consisted of co-infection with two wild-type (WT) RVFV strains, Kenya 128B-15 (Ken06) and Saudi Arabia SA01-1322 (SA01), while group II consisted of co-infection with the live attenuated virus (LAV) vaccine strain MP-12 and a WT strain, Ken06. In the in vitro experiments, the virus supernatants were collected 24 h post-infection. In the in vivo experiments, clinical signs were monitored, and blood and tissues were collected at various time points up to nine days post-challenge for analyses. Cell culture supernatants and samples from sheep were processed, and plaque-isolated viruses were genotyped to determine reassortment frequency. Our results show that RVFV reassortment is more efficient in co-infected sheep-derived cells compared to co-infected sheep. In vitro, the reassortment frequencies reached 37.9% for the group I co-infected cells and 25.4% for the group II co-infected cells. In contrast, we detected just 1.7% reassortant viruses from group I sheep co-infected with the two WT strains, while no reassortants were detected from group II sheep co-infected with the WT and LAV strains. The results indicate that RVFV reassortment occurs at a lower frequency in vivo in sheep when compared to in vitro conditions in sheep-derived cells. Further studies are needed to better understand the implications of RVFV reassortment in relation to virulence and transmission dynamics in the host and the vector. The knowledge learned from these studies on reassortment is important for understanding the dynamics of RVFV evolution.
Pine Response to Sawfly Pheromones: Effects on Sawfly’s Oviposition and Larval Growth
Creators: name: Rahman-Soad, Asifur
name: Bittner, Norbert
name: Hilker, Monika
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: pine
subject: sawfly
subject: herbivore
subject: insect egg
subject: sex pheromone
subject: oviposition
subject: behavior
subject: olfaction
subject: 500 Naturwissenschaften und Mathematik::580 Pflanzen (Botanik)::585 Gymnospermae (Nacktsamer); Coniferae (Nadelgehölze)
subject: 500 Naturwissenschaften und Mathematik::590 Tiere (Zoologie)::590 Tiere (Zoologie)

description: Insect pheromones have been intensively studied with respect to their role in insect communication. However, scarce knowledge is available on the impact of pheromones on plant responses, and how these in turn affect herbivorous insects. A previous study showed that exposure of pine (Pinus sylvestris) to the sex pheromones of the pine sawfly Diprion pini results in enhanced defenses against the eggs of this sawfly; the egg survival rate on pheromone-exposed pine needles was lower than that on unexposed pine. The long-lasting common evolutionary history of D. pini and P. sylvestris suggests that D. pini has developed counter-adaptations to these pine responses. Here, we investigated by behavioral assays how D. pini copes with the defenses of pheromone-exposed pine. The sawfly females did not discriminate between the odor of pheromone-exposed and unexposed pine. However, when they had the chance to contact the trees, more unexposed than pheromone-exposed trees received eggs. The exposure of pine to the pheromones did not affect the performance of larvae and their pupation success. Our findings indicate that the effects that responses of pine to D. pini sex pheromones exert on the sawfly eggs and sawfly oviposition behavior do not extend to effects on the larvae.
Transforming law's family: the legal recognition of planned lesbian families
Creators: name: Kelly, Fiona Jane
Publisher: name: University of British Columbia
Year: 2008

description: Lesbian families with children are greater in number and more visible today than ever before. In fact, social scientists have suggested that we may be in the midst of a lesbian "baby boom". Canada's Census figures support this assertion. Between 2001 and 2006 there was a forty-seven per cent increase in households made up of two lesbian mothers and their children. This dissertation addresses the legal issues raised by lesbian motherhood, focusing primarily on legal parentage. It considers the terms upon which parental recognition has been achieved thus far, and evaluates the efficacy of a reform agenda focused exclusively on gaining access to the existing legal framework. To explore the legal and social dynamics of planned lesbian families, interviews were conducted with forty-nine lesbian mothers living in British Columbia and Alberta who conceived using assisted reproduction. Mothers were asked about the structure of their families, how they defined terms such as "parent" and "family", the extent to which they had engaged with law, and their recommendations for law reform. The interviews revealed that lesbian mothers define family and parenthood broadly, emphasizing intention and caregiving over a purely biological model of kinship. All of the mothers defined a "parent" as someone who intends to parent and, once a child is born, performs that intention through caregiving. Parental status was thus not limited to those who shared a biological relationship with a child, or even to two individuals. The research suggests that lesbian mothers have little interest in being subsumed into the existing legal framework which tends to prioritize dyadic and biological parenting. In fact, only a tiny portion of the mothers felt that identical treatment would adequately respond to their needs. The vast majority supported law reform that would extend to them the benefits of the current system, while simultaneously expanding the existing framework to include a wider variety of parental and family configurations within it. The reform model chosen to achieve this aim combined parental presumptions in favour of the lesbian couple or a single lesbian mother, with opt-in mechanisms that allowed the family to extend beyond the two parent unit.
Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility
Creators: name: Glahn, Imaine
name: Haghofer, Andreas
name: Donovan, Taryn A.
name: Degasperi, Brigitte
name: Bartel, Alexander
name: Kreilmeier-Berger, Theresa
name: Hyndman, Philip S.
name: Janout, Hannah
name: Assenmacher, Charles-Antoine
name: Bartenschlager, Florian
name: Bolfa, Pompei
name: Dark, Michael J.
name: Klang, Andrea
name: Klopfleisch, Robert
name: Merz, Sophie
name: Richter, Barbara
name: Schulman, F. Yvonne
name: Ganz, Jonathan
name: Scharinger, Josef
name: Aubreville, Marc
name: Winkler, Stephan M.
name: Bertram, Christof A.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: anisokaryosis
subject: artificial intelligence
subject: dog
subject: image processing
subject: mitotic count
subject: nuclear pleomorphism
subject: prognosis
subject: pulmonary carcinoma
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: The integration of deep learning-based tools into diagnostic workflows is increasingly prevalent due to their efficiency and reproducibility in various settings. We investigated the utility of automated nuclear morphometry for assessing nuclear pleomorphism (NP), a criterion of malignancy in the current grading system in canine pulmonary carcinoma (cPC), and its prognostic implications. We developed a deep learning-based algorithm for evaluating NP (variation in size, i.e., anisokaryosis and/or shape) using a segmentation model. Its performance was evaluated on 46 cPC cases with comprehensive follow-up data regarding its accuracy in nuclear segmentation and its prognostic ability. Its assessment of NP was compared to manual morphometry and established prognostic tests (pathologists’ NP estimates (n = 11), mitotic count, histological grading, and TNM-stage). The standard deviation (SD) of the nuclear area, indicative of anisokaryosis, exhibited good discriminatory ability for tumor-specific survival, with an area under the curve (AUC) of 0.80 and a hazard ratio (HR) of 3.38. The algorithm achieved values comparable to manual morphometry. In contrast, the pathologists’ estimates of anisokaryosis resulted in HR values ranging from 0.86 to 34.8, with slight inter-observer reproducibility (k = 0.204). Other conventional tests had no significant prognostic value in our study cohort. Fully automated morphometry promises a time-efficient and reproducible assessment of NP with a high prognostic value. Further refinement of the algorithm, particularly to address undersegmentation, and application to a larger study population are required.
Atheta nigra
Creators: name: Klimaszewski, Jan
name: Chandler, Donald S.
name: Davies, Anthony
name: Bourdon, Caroline
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Atheta
Atheta nigra

description: 55. Atheta nigra (Kraatz) †
(Illustrations in Palm 1970, Klimaszewski et al. 2016e), Table 1
References. Kraatz 1856. Palm 1970. Klimaszewski et al. 2016e. Brunke et al. 2021.
Distribution. Palearctic, adventive in North America. Canada: ON, SK. USA (NCR): NH (NSR).
Collection and Habitat data. Caught by sweeping low coastal vegetation in September in NH. In Canada captured on farmland and from horse manure (Brunke et al. 2021).
Material. USA, New Hampshire, Rockingham Co.: Odiorne Point St. Park, 22.IX.2007, D.S. Chandler, sweep, 1 female.
description: Published as part of Klimaszewski, Jan, Chandler, Donald S., Davies, Anthony & Bourdon, Caroline, 2023, Aleocharine rove beetles of New Hampshire, USA: new taxa and new records (Coleoptera, Staphylinidae, Aleocharinae), pp. 1-141 in Zootaxa 5364 (1) on page 33, DOI: 10.11646/zootaxa.5364.1.1, http://zenodo.org/record/10145460
A black-box attack on fixed-unitary quantum encryption schemes
Creators: name: Pilaszewicz, Cezary
name: Muth, Lea R.
name: Margraf, Marian
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Quantum cryptography
subject: Black-box attack
subject: Quantum cryptanalysis
subject: Quantum circuits
subject: 000 Informatik, Informationswissenschaft, allgemeine Werke::000 Informatik, Wissen, Systeme::004 Datenverarbeitung; Informatik

description: We show how fixed-unitary quantum encryption schemes can be attacked in a black-box setting. We use an efficient technique to invert a unitary transformation on a quantum computer to retrieve an encrypted secret quantum state Psi. This attack has a success rate of 100% and can be executed in constant time. We name a vulnerable scheme which security is fully broken by our attack and suggest how to improve the scheme to invalidate this attack. The proposed attack highlights the importance of carefully designing quantum encryption schemes to ensure their security against quantum adversaries, even in a black-box setting. We point to the faulty assumption and name a criterion for future quantum cipher design to prevent similar vulnerabilities.
Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection
Creators: name: Elizalde-Velázquez, Luis E.
name: Schlosser-Brandenburg, Josephine
name: Laubschat, Alexandra
name: Oser, Larissa
name: Kundik, Arkadi
name: Adjah, Joshua
name: Groenhagen, Saskia
name: Kühl, Anja A.
name: Rausch, Sebastian
name: Hartmann, Susanne
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Innate immunity
subject: Mucosal immunology
subject: Parasitic infection
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Helminth infections lead to an overdispersion of the parasites in humans as well as in animals. We asked whether early immune responses against migrating Ascaris larvae are responsible for the unequal distribution of worms in natural host populations and thus investigated a susceptible versus a resistant mouse strain. In mice, the roundworm larvae develop until the lung stage and thus early anti-Ascaris immune responses against the migrating larvae in the liver and lung can be deciphered. Our data show that susceptible C57BL/6 mice respond to Ascaris larval migration significantly stronger compared to resistant CBA mice and the anti-parasite reactivity is associated with pathology. Increased eosinophil recruitment was detected in the liver and lungs, but also in the spleen and peritoneal cavity of susceptible mice on day 8 post infection compared to resistant mice. In serum, eosinophil peroxidase levels were significantly higher only in the susceptible mice, indicating functional activity of the recruited eosinophils. This effect was associated with an increased IL-5/IL-13 production by innate lymphoid cells and CD4+ T cells and a pronounced type 2 macrophage polarization in the lungs of susceptible mice. Furthermore, a comparison of wildtype BALB/c and eosinophil-deficient dblGATA-1 BALB/c mice showed that eosinophils were not essential for the early control of migrating Ascaris larvae. In conclusion, in primary infection, a strong local and systemic type 2 immune response during hepato-tracheal helminth larval migration is associated with pathology rather than protection.
Africonus decoratus
Creators: name: Tenorio, Manuel J.
name: Abalde, Samuel
name: Pardos-Blas, José R.
name: Zardoya, Rafael
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neogastropoda
Conidae
Africonus
Africonus decoratus

description: Africonus decoratus (Röckel, Rolán & Monteiro, 1980)Fig. 3L, 5L
Conus decoratus Röckel et al., 1980a: 61, pl. II, figs 29–33.
Conus decoratus – Monteiro et al. 2004: 38, pls 119–120, figs 1–2, 4–8.
Material examined
Holotype
CABO VERDE • 20.6 mm; São Vicente Island, Matiota Beach; 1 to 3 m depth; NMSF.
Other material
CABO VERDE • 1 spec., 23.1 mm; Santa Luzia Island, Curral; 16º46ʹ23ʺ N, 24º47ʹ13ʺ W; 14 Apr. 2016; MNCN exped.; GenBank mitochondrion, partial genome: MF491603; MNCN 15.05/78589 (Fig. 3L) • 1 spec., 30.5 mm; Santa Luzia Island, Praia de Palmo Tostão; 16º45ʹ19ʺ N, 24º45ʹ24ʺ; 14 Apr. 2016; MNCN exped.; MNCN 15.05/78578 (Fig. 5L).
Geographical distribution
Calhau to Saragaça, on the southeast coast of São Vicente Island, and Curral area, on the southwest coast of Santa Luzia Island, Cabo Verde Archipelago.
Conservation status in IUCN Red List
Vulnerable.
Remarks
This species belongs to a lineage that includes species endemic to the westernmost islands in the Cabo Verde Archipelago and is sister to species from Santiago and Maio islands. Despite obvious differences in shell morphology, the species sister to A. decoratus according to the phylogeny is A. grahami. The type locality from which A. decoratus was originally described is now part of a large and touristic urban area in the vicinity of the modern Port of Mindelo. This population (decoratus form A in Röckel et al. 1980a) is believed to be now extinct, but specimens from other population (decoratus form B in Röckel et al. 1980a) are occasionally found on the east coast of São Vicente Island from Calhau to Saragaça, and more commonly on the deserted island of Santa Luzia, where the specimens used in the present study were collected. This beautifully patterned species shows some degree of variation in its background color, which ranges from light brown to black.
description: Published as part of Tenorio, Manuel J., Abalde, Samuel, Pardos-Blas, José R. & Zardoya, Rafael, 2020, Taxonomic revision of West African cone snails (Gastropoda: Conidae) based upon mitogenomic studies: implications for conservation, pp. 1-89 in European Journal of Taxonomy 663 (663) on page 20, DOI: 10.5852/ejt.2020.663, http://zenodo.org/record/3890442
Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs
Creators: name: Mugo, Robert M.
name: Oser, Larissa
name: Midha, Ankur
name: Adjah, Joshua
name: Kundik, Arkadi
name: Laubschat, Alexandra
name: Höfler, Philipp
name: Musimbi, Zaneta D.
name: Hayani, Rima
name: Schlosser-Brandenburg, Josephine
name: Hartmann, Susanne
name: Rausch, Sebastian
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Ascaris
subject: Salmonella
subject: Natural killer cells
subject: Coinfection
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Natural killer (NK) cells play a key role in defense against Salmonella infections during the early phase of infection. Our previous work showed that the excretory/secretory products of Ascaris suum repressed NK activity in vitro. Here, we asked if NK cell functionality was influenced in domestic pigs during coinfection with Ascaris and Salmonella enterica serotype Typhimurium. Ascaris coinfection completely abolished the IL-12 and IL-18 driven elevation of IFN-γ production seen in CD16 + CD8α + perforin + NK cells of Salmonella single-infected pigs. Furthermore, Ascaris coinfection prohibited the Salmonella-driven rise in NK perforin levels and CD107a surface expression. In line with impaired effector functions, NK cells from Ascaris-single and coinfected pigs displayed elevated expression of the inhibitory KLRA1 and NKG2A receptors genes, contrasting with the higher expression of the activating NKp46 and NKp30 receptors in NK cells during Salmonella single infection. These differences were accompanied by the highly significant upregulation of T-bet protein expression in NK cells from Ascaris-single and Ascaris/Salmonella coinfected pigs. Together, our data strongly indicate a profound repression of NK functionality by an Ascaris infection which may hinder infected individuals from adequately responding to a concurrent bacterial infection.
Atheta (Datomicra) particula NB, NS, ON, QC
Creators: name: Klimaszewski, Jan
name: Chandler, Donald S.
name: Davies, Anthony
name: Bourdon, Caroline
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Atheta
Atheta particula

description: 57. Atheta (Datomicra) particula (Casey)
(Illustrations in Klimaszewski et al. 2018), Table 1
References. Casey 1910. Klimaszewski et al. 2005a, 2007, 2018. Majka and Klimaszewski 2010. Brunke et al. 2012.
Distribution. Nearctic. Canada: NB, NS, ON, QC. USA: NH (NSR), NY, RI.
Collection and Habitat data. The single NH female was captured in an old-growth coniferous forest near the border with Quebec in September by a FIT. In Canada found in hardwood, mixed, and coniferous forests, usually in fungi such as decaying mushrooms, small white gilled mushrooms, polypore fungi on log, Russula mushrooms, and a large (old) fleshy polypore fungus on a beech log. Also collected using Malaise pan traps and unbaited pitfall traps in a hemlock forest, sugar maple forest, red spruce dominated forest (common), a yellow birch forest, and an old field (Klimaszewski 2018).
Material. USA, New Hampshire, Coos Co.: Norton Pool, 3 mi NE East Inlet Dam, 13–26.IX.1986, D.S. Chandler, FIT, 1 male.
description: Published as part of Klimaszewski, Jan, Chandler, Donald S., Davies, Anthony & Bourdon, Caroline, 2023, Aleocharine rove beetles of New Hampshire, USA: new taxa and new records (Coleoptera, Staphylinidae, Aleocharinae), pp. 1-141 in Zootaxa 5364 (1) on page 35, DOI: 10.11646/zootaxa.5364.1.1, http://zenodo.org/record/10145460
Using expired weather forecasts to supply up to 10000 years of data
Creators: name: Dolezal, Petr
Publisher: name: Zenodo
Year: 2024

description: This work presents a method for improving climate-related planning by utilizing ensemble weather forecasts previously computed for short-term weather predictions. By re-analyzing these forecasts, which reflect the atmospheric conditions of the last twenty years, but contain more than a hundred times more information, we can significantly enhance the accuracy of near-future climate estimates. This approach bridges the gap between the detailed weather records traditionally used to define climate, but now describing an atmosphere of the past, and the coarse GCM methods, offering insights applicable to the new climate conditions, allowing us to take the correct actions.