cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Expanding the flexibility of genome editing approaches for population control of the malaria mosquito
Creators: name: Kranjc, Nace
Publisher: name: Imperial College London
Year: 2021

description: Discovery and adaptation of CRISPR-Cas systems for genome editing have allowed us to gain an efficient and yet simple tool for genetic manipulation in various fields of molecular biology and biotechnology. One of the most promising applications is the use of CRISPR-Cas9 endonuclease for gene drive systems as a population control strategy for various insect pests of medical and agricultural importance. Use of CRISPR-Cas9 endonuclease in gene drive applications has shown great promise in the laboratory, particularly for the control of Anopheles gambiae, the major vector of malaria. However, the performance of such gene drives can be limited by the range of available target sequences and by a propensity of existing endonuclease formulations to generate resistant mutations that hinder the gene drive’s efficiency. To expand the flexibility of gene drive systems, computational analysis was performed to identify additional Cas9 orthologs and their specificities that could usefully augment the targeting range of endonuclease-based gene drives. Two alternative variants of CRISPR-Cas endonucleases found in the bacterial species Lactobacillus rhamnosus and Bacteroides fragilis were assessed for their potential to expand the targeting space in the genome Anopheles gambiae. In addition, a computational tool was developed that evaluates neighbouring sequences to the target site to measure both its likely functional constraint and its likely propensity for DNA repair that could generate in-frame alleles. Using this approach we were able to generate a prioritized list of Anopheles gambiae target sites for gene drive applications that are less likely to be compromised by resistant alleles.
Count Basie, Eleventh Annual Stony Brook Music Festival, July 2, 1966
Creators: name: Stony Brook Community Fund
Publisher: name: Unknown
Year: 1966
Subjects: Music festivals
Stony Brook
Programs
Amphitheaters

description: This is the Eleventh Annual Stony Brook Music Festival Program, featuring Count Basie and His Orchestra. The program gives bio and accolades for Count Basie. ac. Basie was an American jazz musician noted for his spare, economical piano style and for his leadership of influential and widely heralded big band.
The relationship between creativity, imitation, and cultural diversity
Creators: name: Gabora, Liane
name: Leijnen, Stefan
Publisher: name: International Journal of Software and Informatics
Year: 2018

description: There are both benefits and drawbacks to cultural diversity. It can lead to friction and exacerbate differences. However, as with biological diversity, cultural diversity is valuable in times of upheaval; if a previously effective solution no longer works, it is good to have alternatives available. What factors give rise to cultural diversity? This paper describes a preliminary investigation of this question using a computational model of cultural evolution. The model is composed of neural network based agents that evolve fitter ideas for actions by (1) inventing new ideas through modification of existing ones, and (2) imitating neighbors' ideas. Numerical simulations indicate that the diversity of ideas in a population is positively correlated with both the proportion of creators to imitators in the population, and the rate at which creators create. This is the case for both minimum and peak diversity of actions over the duration of a run.
Synthesis and Characterization of Fluorinated Cytosporone-Like Activators of NR4A1
Creators: name: Holmes, Kamara
Publisher: name: Zenodo
Year: 2025

description: Cocaine Use Disorder (CUD) is a chronic, relapsing condition marked by disrupted dopamine signaling and long-term changes in neural plasticity. Current treatments are limited, and relapse rates remain high. Recent studies identify NR4A1/NUR77, an orphan nuclear receptor and immediate-early gene, as a key regulator of the brain’s response to cocaine. CART (cocaine- and amphetamine-regulated protein transcript, encoded by CARTPT) is a neuropeptide that plays a crucial role in mediating satiety and reward in mesolimbic dopaminergic circuitry. Activation of Nr4a1 using small molecules such as Cytosporone B (Csn-B) has been shown to selectively reduce drug-seeking behavior in drug-primed animals through increased transactivation at the Cartpt gene promoter, highlighting Nr4a1 as a potential therapeutic target for CUD. This project focused on synthesizing and characterizing analogs of Csn-B with improved pharmacokinetic properties, especially blood-brain barrier (BBB) permeability, and metabolic stability. Analogs were prioritized based on their predicted binding and drug-like properties using in silico docking (AutoDock Vina) and pharmacokinetic prediction tools (SwissADME). Key synthetic strategies included late-stage fluorination and macrocyclization to enhance lipophilicity and molecular rigidity. A new compound, KMH-0046, was synthesized via Friedel–Crafts acylation of a fluoro-aryl ester followed by selective demethylation. Biological assays in SH-SY5Y neuroblastoma cells showed that KMH-0046 significantly increased NR4A1 expression at non-toxic doses, matching the efficacy of Csn-B but with more robust activation of genes associated with dopamine homeostasis, such as CARTPT and TH (tyrosine hydroxylase). These findings support the use of fluorination to enhance both biological activity and pharmacological potential. Overall, the project advances the understanding of NR4A1 as a drug target in addiction and identifies KMH-0046 as a lead compound for further development. Future directions include expanding compound libraries, performing direct receptor-binding studies, and evaluating in vivo efficacy in mouse models of CUD.
A suite of quantum algorithms for the shortestvector problem
Creators: name: Joseph, David
Publisher: name: Imperial College London
Year: 2021

description: Crytography has come to be an essential part of the cybersecurity infrastructure that provides a safe environment for communications in an increasingly connected world. The advent of quantum computing poses a threat to the foundations of the current widely-used cryptographic model, due to the breaking of most of the cryptographic algorithms used to provide confidentiality, authenticity, and more. Consequently a new set of cryptographic protocols have been designed to be secure against quantum computers, and are collectively known as post-quantum cryptography (PQC). A forerunner among PQC is lattice-based cryptography, whose security relies upon the hardness of a number of closely related mathematical problems, one of which is known as the shortest vector problem (SVP). In this thesis I describe a suite of quantum algorithms that utilize the energy minimization principle to attack the shortest vector problem. The algorithms outlined span the gate-model and continuous time quantum computing, and explore methods of parameter optimization via variational methods, which are thought to be effective on near-term quantum computers. The performance of the algorithms are analyzed numerically, analytically, and on quantum hardware where possible. I explain how the results obtained in the pursuit of solving SVP apply more broadly to quantum algorithms seeking to solve general real-world problems; minimize the effect of noise on imperfect hardware; and improve efficiency of parameter optimization.
Safe and effective prescription of exercise in acute exacerbations of chronic obstructive pulmonary disease : rationale and methods for an integrated knowledge translation study
Creators: name: Yamabayashi, Cristiane
name: Brooks, Dina
name: Goodridge, Donna
name: Chung, Frank
name: Marciniuk, Darcy D
name: Neufeld, Andrea
name: Hoens, Alison
name: Camp, Pat
name: Reid, Wendy Darlene
Publisher: name: The University of British Columbia
Year: 2018

description: BACKGROUND: Patients hospitalized with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) engage in low levels of activity, putting them at risk for relapse and future readmissions. There is little direction for health care providers regarding the parameters for safe exercise during an AECOPD that is effective for increasing activity tolerance before discharge from hospital, especially for patients with associated comorbid conditions. OBJECTIVE: To report the rationale for and methods of a study to develop evidence-informed care recommendations that guide health care providers in the assessment, prescription, monitoring and progression of exercise for patients hospitalized with AECOPD. METHODS: The present study was a multicomponent knowledge translation project incorporating evidence from systematic reviews of exercise involving populations with chronic obstructive pulmonary disease and/or common comorbidities. A Delphi process was then used to obtain expert opinion from clinicians, academics and patients to identify the parameters of safe and effective exercise for patients with AECOPD. RESULTS: Clinical decision-making tool(s) for patients and practitioners supported by a detailed knowledge dissemination, implementation and evaluation framework. CONCLUSION: The present study addressed an important knowledge gap: the lack of availability of parameters to guide safe and effective exercise prescription for hospitalized patients with AECOPD, with or without comorbid conditions. In the absence of such parameters, health care professionals may adopt an ‘activity as tolerated’ approach, which may not improve physical activity levels in their patients. The present study synthesizes the best available evidence and expert opinion, and will generate decision-making tools for use by patients and their health care providers.
How ecosystem functioning in tropical forests varies with anthropogenic land use and environmental change
Creators: name: Harrison, Michelle
Publisher: name: Imperial College London
Year: 2019

description: The combined effect of habitat degradation and shifts in climate are pushing many species towards local and global extinctions. Often, the most sensitive species to disturbance are the most important for the maintenance of healthy ecosystems. With conservation efforts focussing on biodiversity, can we assume that ecosystem functions will also be preserved? We aimed to test these assumptions by disrupting trophic interactions along natural and anthropogenic gradients of diversity with vertebrate exclusions. In chapter two, we focus on shifts in biotic distribution that occur naturally with elevation. Vertebrate exclusion caused strong trophic cascades on herbivory in pristine tropical forests, but only at high altitudes. In contrast, at lower elevations, forests showed little response to predator exclusion, with no effect on herbivore density or subsequent plant damage. We hypothesis that habitat in the warmer and wetter lowlands harbours higher levels of diversity within mid and low trophic levels and this may confer some resilience to disturbance. In chapters three and four, we investigate how distance to edge and habitat loss effects the above processes. Edge effects significantly mediated trophic cascades, which occurred only within the forest interior. Changes in vertebrate community composition along interior to edge gradients are likely to be responsible for these findings. The effect of exclusion on both arthropod densities was mediated by habitat loss, although the proportion of plant damage was not. The generality of plant-herbivore interactions may make them robust to perturbation, hence the neutral response of herbivory to habitat loss. Our findings provide insight into how the provision of ecosystem function is mediated by biodiversity loss. This information can be vital in identifying which areas of habitat might lose functionality in the wake of disturbance. We 6 suggest that conservation efforts are refocussed to target ecosystems in which functions are reliant on vulnerable specialist species.
Simulation of Single-Phase Natural Circulation within the BEPU Framework: Sketching Scaling Uncertainty Principle by Multi-Scale CFD Approaches
Creators: name: Huang, Haifu
name: Perez, Jorge
name: Alpy, Nicolas
name: Medale, Marc
Publisher: name: arXiv
Year: 2024
Subjects: subject: Classical Physics (physics.class-ph)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In order to enhance safety, nuclear reactors in the design phase consider natural circulation as a mean to remove residual power. The simulation of this passive mechanism must be qualified between the validation range and the scope of utilization (reactor case), introducing potential physical and numerical distortion effects. In this study, we simulate the flow of liquid sodium using the TrioCFD code, employing both higher-fidelity (HF) LES and lower-fidelity (LF) URANS models. We tackle respectively numerical uncertainties through the Grid Convergence Index method, and physical modelling uncertainties through the Polynomial Chaos Expansion method available on the URANIE platform. HF simulations are shown to exhibit a strong resilience to physical distortion effects, with numerical uncertainties being intricately correlated. Conversely, the LF approach, the only one applicable at the reactor scale, is likely to present a reduced predictability. If so, the HF approach should be effective in pinpointing the LF weaknesses: the concept of scaling uncertainty is inline introduced as the growth of the LF simulation uncertainty associated with distortion effects. Thus, the paper outlines that a specific methodology within the BEPU framework - leveraging both HF and LF approaches - could pragmatically enable correlating distortion effects with scaling uncertainty, thereby providing a metric principle.
Fatigue and mental underload further pronounced in L3 conditionally automated driving: Results from an EEG experiment on a test track
Creators: name: Figalová, Nikol
name: Bieg, Hans Joachim
name: Schulz, Michael
name: Pichen, Jürgen
name: Baumann, Martin
name: Chuang, Lewis
name: Pollatos, Olga
Publisher: name: arXiv
Year: 2024
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Drivers' role changes with increasing automation from the primary driver to a system supervisor. This study investigates how supervising an SAE L2 and L3 automated vehicle (AV) affects drivers' mental workload and sleepiness compared to manual driving. Using an AV prototype on a test track, the oscillatory brain activity of 23 adult participants was recorded during L2, L3, and manual driving. Results showed decreased mental workload and increased sleepiness in L3 drives compared to L2 and manual drives, indicated by self-report scales and changes in the frontal alpha and theta power spectral density. These findings suggest that fatigue and mental underload are significant issues in L3 driving and should be considered when designing future AV interfaces.
Knowledge brokering : An innovative model for supporting evidence-informed practice in respiratory care
Creators: name: Camp, Pat
name: Hoens, Alison
name: Reid, Wendy Darlene
Publisher: name: The University of British Columbia
Year: 2018

description: The process of adopting research findings in the clinical setting is challenging, regardless of the area of practice. One strategy to facilitate this process is the use of knowledge brokering. Knowledge brokers (KBs) are individuals who work to bridge the gap between researchers and knowledge users. In the health care setting, KBs work closely with clinicians to facilitate enhanced uptake of research findings into clinical practice. They also work with researchers to ensure research findings are translatable and meaningful to clinical practice. The present article discusses a KB’s role in a respiratory care setting. Working closely with both researchers and clinicians, the KB has led teams in the process of conceptualizing, developing, testing, disseminating and evaluating several projects related to respiratory care, including projects related to mobility in critical care settings and acute exacerbations of chronic obstructive pulmonary disease; inspiratory muscle training; and the use of incentive spirometry in postsurgical populations. The KB role has provided an important communication link between researcher and knowledge user that has facilitated evidence-informed practice to improve patient care.
A correlation between supermassive black hole mass and galaxy light concentration
Creators: name: Graham, Alister
name: Erwin, Peter
name: Caon, Nicola
name: Trujillo, Ignacio
Publisher: name: Swinburne
Year: 2024

description: The varying global distribution of stars, or specifically, their concentration Cr_e, within elliptical galaxies and spiral galaxy bulges is intimately related to the mass of their central supermassive black holes (Mbh), such that log (Mbh/Msun) = 6.81(±0.95)Cr_e + 5.03±0.41. This correlation has a Spearman correlation coefficient rs=0.91, and a scatter of only 0.31 dex in log Mbh. Removing one well understood outlying data point and using only those galaxies whose supermassive black hole's radius of influence has been resolved (reducing the sample size from 21 to 13) results in a scatter of only 0.19 dex.
Fractional Order and Inverse Problem Solutions for Plate Temperature Control
Creators: name: Jarrah, Bilal
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Inverse Problem Approach
Fractional Order Approach
Surface Temperature Control
Zero-Pole Expansion

description: Surface temperature control of a thin plate is investigated. Temperature is controlled on one side of the plate using the other side temperature measurements. This is a decades-old problem, reactivated more recently by the awareness that this is a fractional-order problem that justifies the investigation of the use of fractional order calculus. The approach is based on a transfer function obtained from the one-dimensional heat conduction equation solution that results in a fractional-order s-domain representation. Both the inverse problem approach and the fractional controller approach are studied here to control the surface temperature, the first one using inverse problem plus a Proportional only controller, and the second one using only the fractional controller. The direct problem defined as the ratio of the output to the input, while the inverse problem defined as the ratio of the input to the output. Both transfer functions are obtained, and the resulting fractional-order transfer functions were approximated using Taylor expansion and Zero-Pole expansion. The finite number of terms transfer functions were used to form an open-loop control scheme and a closed-loop control scheme. Simulation studies were done for both control schemes and experiments were carried out for closed-loop control schemes. For the fractional controller approach, the fractional controller was designed and used in a closed-loop scheme. Simulations were done for fractional-order-integral, fractional-order-derivative and fractional-integral-derivative controller designs. The experimental study focussed on the fractional-order-integral-derivative controller design. The Fractional-order controller results are compared to integer-order controller’s results. The advantages of using fractional order controllers were evaluated. Both Zero-Pole and Taylor expansions are used to approximate the plant transfer functions and both expansions results are compared. The results show that the use of fractional order controller performs better, in particular concerning the overshoot.
Synthesis and Characterization of Cytosporone-Like NR4A1 Agonists: Potential Therapeutics of Cocaine Use Disorder
Creators: name: Holmes, Kamara M
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Orphan Nuclear Receptors
subject: Chemistry
subject: Chemistry, Organic
subject: cocaine use disorder
subject: Drug Discovery

description: Cocaine Use Disorder (CUD) is a chronic, relapsing condition marked by disrupted dopamine signaling and long-term changes in neural plasticity. Current treatments are limited, and relapse rates remain high. Recent studies identify NR4A1/NUR77, an orphan nuclear receptor and immediate-early gene, as a key regulator of the brain’s response to cocaine. CART (cocaine- and amphetamine-regulated protein transcript, encoded by CARTPT) is a neuropeptide that plays a crucial role in mediating satiety and reward in mesolimbic dopaminergic circuitry. Activation of Nr4a1 using small molecules such as Cytosporone B (Csn-B) has been shown to selectively reduce drug-seeking behavior in drug-primed animals through increased transactivation at the Cartpt gene promoter, highlighting Nr4a1 as a potential therapeutic target for CUD. This project focused on synthesizing and characterizing analogs of Csn-B with improved pharmacokinetic properties, especially blood-brain barrier (BBB) permeability, and metabolic stability. Analogs were prioritized based on their predicted binding and drug-like properties using in silico docking (AutoDock Vina) and pharmacokinetic prediction tools (SwissADME). Key synthetic strategies included late-stage fluorination and macrocyclization to enhance lipophilicity and molecular rigidity. A new compound, KMH-0046, was synthesized via Friedel–Crafts acylation of a fluoro-aryl ester followed by selective demethylation. Biological assays in SH-SY5Y neuroblastoma cells showed that KMH-0046 significantly increased NR4A1 expression at non-toxic doses, matching the efficacy of Csn-B but with more robust activation of genes associated with dopamine homeostasis, such as CARTPT and TH (tyrosine hydroxylase). These findings support the use of fluorination to enhance both biological activity and pharmacological potential. This research also initiated the synthesis of macrocyclic analogs, preserving terminal alkenes for future ring-closing metathesis. Overall, the project advances the understanding of NR4A1 as a drug target in addiction and identifies KMH-0046 as a lead compound for further development. Future directions include expanding compound libraries, performing direct receptor-binding studies, and evaluating in vivo efficacy in mouse models of CUD.
QuASoQ 2019 : Quantitative Approaches to Software Quality : Proceedings of the 7th International Workshop on Quantitative Approaches to Software Quality, co-located with 26th Asia-Pacific Software Engineering Conference (APSEC 2019), Putrajaya, Malaysia, December 2, 2019
Creators: name: Lichter, Horst
name: Fögen, Konrad
name: Sunetnanta, Thanwadee
name: Anwar, Toni
Publisher: name: RWTH Aachen University
Year: 2019

description: 7th International Workshop on Quantitative Approaches to Software Quality, QuASoQ 2019, Putrajaya, Malaysia, 2 Dec 2019 - 2 Dec 2019; Aachen, Germany : RWTH Aachen, CEUR Workshop Proceedings 2511, 52 Seiten (2019).
description: Published by RWTH Aachen, Aachen, Germany
Classification of Frequency Following Responses to English Vowels in a Biometric Application
Creators: name: Sun, Rui
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Classification
Auditory Brainstem Response
Frequency Following Response
Machine Learning
Neural Network

description: The objective of this thesis is to characterize and identify the representation of four short English vowels in the frequency following response (FFR) of 22 normal-hearing adult subjects. The results of two studies are presented, with some analysis. The result of the first study indicates how the FFR signal of four short vowels can be used to identity different subjects. Meanwhile, a rigorous test was conducted to test and verify the quality and consistency of responses from each subject between test and retest, in order to provide strong and representative features for subject identification. The second study utilized machine learning and deep learning classification algorithms to exploit features extracted from the FFRs, in both time and frequency domains, to accurately identify subjects from their responses. We used three kinds of classifiers with respect to three aspects of the features, yielding a highest classification accuracy of 86.36%. The results of the studies provide positive and important implications for establishing a biometric authentication system using speech-evoked FFRs.
Sex, hormones, and neurogenesis in the hippocampus : Hormonal modulation of neurogenesis and potential functional implications
Creators: name: Galea, Liisa A. M.
name: Wainwright, Steven R.
name: Duarte-Guterman, Paula
name: Chow, Carmen
name: Hamson, Dwayne K.
name: Roes, Meighen Maria
Publisher: name: The University of British Columbia
Year: 2018

description: The hippocampus is an area of the brain that undergoes dramatic plasticity in response to experience and hormone exposure. The hippocampus retains the ability to produce new neurons in most mammalian species and is a structure that is targeted in a number of neurodegenerative and neuropsychiatric diseases, many of which are influenced by both sex and sex hormone exposure. Intriguingly, gonadal and adrenal hormones affect the structure and function of the hippocampus differently in males and females. Sex differences in the effects of steroid hormones to modulate hippocampal plasticity should not be completely surprising as the physiology of males and females is different, with the most notable difference that the females gestate and nurse the offspring. Furthermore, reproductive experience (pregnancy and mothering) results in permanent changes to the maternal brain, including the hippocampus in females. Adult neurogenesis in the hippocampus is regulated by both gonadal and adrenal hormones in a sex and experience-dependent way. This review outlines the ability of gonadal and stress hormones to modulate multiple aspects of neurogenesis (cell proliferation and cell survival) in both male and female rodents. The function of adult neurogenesis in the hippocampus is linked to spatial memory and depression and this review provides early evidence of the functional links between hormonal modulation of neurogenesis to regulate cognition and stress.
SSHRC SELECTION COMMITTEES SAY ….(2022)
Creators: Heather Young-Leslie
Publisher: name: University of Alberta Library
Year: 2022

Presentation for faculty applying to SSHRC research competitions, includes summaries of selection committee members' feedback re: who and what succeeds, what to do and not do in an application, and the rubric committees use to evaluate proposals. Includes recent (2022) analysis of each committee's average success rates (2018-2020) and comparison of English vs French language submissions.
Dynamic Mechanical Regulation of Cells in 3D Microtissues
Creators: name: Walker, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Mechanobiology
Microtissue
Cytoskeleton
Myofibroblast
Cell mechanics
3D cell culture

description: It has been well established that the fundamental behaviors of mammalian cells are influenced by the physical cues that they experience from their surrounding environment. With respect to cells in our bodies, mechanically-driven morphological and phenotypic changes to our cells have been linked to responses critical to both normal development and disease progression, including lung, heart, muscle and bone disorders, and cancer. Although significant advancements to our understanding of cell behavior have been made using 2D cell culture methods, questions regarding how physical stretch guides cell behavior in more complex 3D biological systems remain unanswered. To address these questions, we used microfabrication techniques to develop vacuum-actuated stretchers for high throughput stretching and dynamic mechanical screening of 3D microtissue cultures. This thesis contains five research chapters that have utilized these devices to advance our understanding of how cells feel stretch and how it influences their behavior in a 3D matrix. In the first research chapter (chapter 2), we characterized how stretch is transferred from the tissue-level to the single-cell level and we investigated the cytoskeletal reinforcement response to long-term mechanical conditioning. In the second research chapter (chapter 3), we examined the effects of an acute dynamic stretch and found that 3D cultures soften through actin depolymerization to homeostatically maintain a mean tension. This softening response to stretch may lengthen tissues in our body, and thus may be an important mechanism by which airway resistance and arterial blood pressure are controlled. In the third and forth research chapters (chapter 4-5), we investigated the time dependencies of microtissues cultures and we found that their behavior differed from our knowledge of the rheological behavior of cells in 2D culture. Microtissues instead followed a stretched exponential model that seemed to be set by a dynamic equilibrium between cytoskeletal assembly and disassembly rates. The difference in the behavior from cells in 2D may reflect the profound changes to the structure and distribution of the cytoskeleton that occur when cells are grown on flat surfaces vs. within a 3D environment. In the fifth and final research chapter (chapter 6), we examined how mechanical forces may contribute to the progression of tissue fibrosis through activating latent TGF-β1. Our results suggest that mechanical stretch contributes to a feed forward loop that preserves a myofibroblastic phenotype. Together these investigations further our understanding of how cells respond to mechanical stimuli within 3D environments, and thus, mark a significant contribution to the fields of mechanobiology and cell mechanics.
How Does Investor Sentiment Have Impacts on Stock Returns and Volatility in the Growth Enterprise Market in China?
Creators: name: Zheng, Jinshi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Investor sentiment
Stock returns

description: This dissertation mainly explores the effect of investor sentiment on stock returns and volatility on Growth Enterprise in China using monthly data from Shenzhen Stock Exchange of China from June 2010 to November 2019. Using five explicit and market-related implicit indicators an investor sentiment has been measured and constructed with the help of principal component analysis. The analysis has been done by employing a vector autoregression(VAR) model and impulse response functions (IRFs) generated from a VAR model to examine the relationship between the unanticipated changes in investor sentiment and stock returns and volatility. We also establish EGARCH model to test the validity of previous results and if the asymmetric impact of positive and negative news on market returns volatility. The results show a significant impact of investor sentiment on stock return and volatility. We also document that there is a positive leverage effect between investor sentiment and the volatility of returns. The findings of this paper can help both individual and institutional investors have a better understanding of GEM market and improve their investment returns by incorporating investor sentiment into their asset forecasting model. This paper also provides policymakers guidance on reducing volatility on stock markets from the perspective of investor sentiment. Additionally, this paper has important contributions to behavioral finance and adds to the limited number of studies on investor sentiment and stock return in not only the Chinese market but emerging markets.
Theodore Bikel, Tenth Annual Stony Brook Music Festival Program, August 7, 1965
Creators: name: Stony Brook Community Fund
Publisher: name: Unknown
Year: 1965
Subjects: Stony Brook
Music festivals
Amphitheaters
Programs

description: This is the Tenth Annual Stony Brook Music Festival Program, dated for August 7, 1965, featuring Theodore Bikel. Sixth act was Theodore Bikel. He was an Austrian-American actor, folk singer, musician, composer, unionist, and political activist
Collaborative Writing Across English Proficiencies: Using Professionals' Experiences in the Workplace to Scaffold Students' Teamwork Practices
Creators: name: Feuer, Maria
Publisher: name: Carnegie Mellon University
Year: 2022
Subjects: Rhetoric

description: When co-writing on linguistically diverse teams, team members have the potential to engage in perspective sharing and perspective taking, which can produce more innovative and creative texts. At the same time, linguistically diverse teams can often reproduce some of the worst inequities in our society, such as domineering teammates, discrimination and undervaluation, distrust and degradation of status, exclusion from group participation, stereotyping, and increased anxieties during interactions. It is, therefore, no surprise that students often feel anxiety when collaborating on linguistically diverse teams. The objective of this dissertation is to explore a team pedagogy that encourages students to overcome their anxieties about language differences and more productively collaborate with their diverse peers. Using interviews and survey data, I created and piloted pedagogical material that aims to help students better collaborate on their diverse teams. Specifically, in Chapter 1, I reevaluated the ways that the field of professional and technical writing teaches teamwork in the classroom. In Chapter 2, I interviewed professionals who frequently collaborate on linguistically diverse teams to explore best practices commonly used by experts in the field. In Chapter 3, I revised the Team Communication workshop from a traditional approach into a flipped model, where students were given a chance to reflect on and individually interact with the teamwork strategies on their own terms. In order to address students’ challenges with having difficult conversations about language and feedback, in Chapter 4, I created a flipped approach that scaffolds the team charter document and helps students overcome the anxieties around discussing different values, goals, and needs. My findings show that students self-reported an increased use of team planning strategies, and their team documents show an increased use of empathetic discourse towards their peers. This dissertation contributes to the fields of rhetoric and professional and technical communication by offering teachers concrete tools that they can use to support the exchange of diverse perspectives in the classroom.
Antidepressant Use during Pregnancy and Serotonin Transporter Genotype (SLC6A4) Affect Newborn Serum Reelin Levels
Creators: name: Brummelte, Susanne
name: Galea, Liisa A. M.
name: Devlin, Angela Marie
name: Oberlander, Tim F.
Publisher: name: The University of British Columbia
Year: 2019

description: This study was undertaken to determine whether altered early serotonin signaling either via gestational serotonin reuptake inhibitor (SRI) exposure or genetic variations in the serotonin transporter promoter region (SLC6A4) alters levels of reelin, an important glycoprotein in neurodevelopment, in mothers and their neonates. Serum reelin protein expression was quantified by immunoblot from maternal and neonatal blood collected at delivery from women taking either an SRI during gestation or controls. SRI-exposed mothers had higher levels of one reelin fragment, while SRI-exposed neonates had lower total reelin levels, particularly in females and reelin levels differed with SLC6A4 genotype. Lower neonatal reelin levels predicted less time spent sleeping and more irritability during neonatal behavioral assessment on day 6 of life. Our results suggest that prenatal SRI exposure and the SLC6A4 genotype influences reelin protein expression in both the mother and newborn and that this may be reflected in neonatal behavior.
Exploring citizen science in art-practice methodologies as forms of comminity practice in biodiversity monitoring
Creators: name: Wandl-Vogt, Eveline
name: Rocha, Aleyda
Publisher: name: Zenodo
Year: 2022
Subjects: Citizen Science
Inclusion
Youth
SDGs
Biodiversity
Farmers
Art-pracitices
Art Driven Innovation
Edcuation
Citizen Science Award

description: Presentation given in the framework of the tSTS Graz 2022 conference
 Thematic Field: Open Science: Rethinking the Science and Society Relationship
 Session: A.3 Inclusion and Exclusion in Citizen Science chaired by Michael Strähle and Christine Urban / Science Shop, Vienna, Austria

 The Project is kindly funded by FWF, under the European CHIST-ERA theme.
Mischa Elman, Tenth Annual Stony Brook Music Festival, July 31, 1965
Creators: name: Stony Brook Community Fund
Publisher: name: Unknown
Year: 1965
Subjects: Stony Brook
Music festivals
Programs
Amphitheaters

description: This is the Tenth Annual Stony Brook Music Festival program, dated for July 31, 1965, featuring Micha Elman. The fifth act is Micha Elman. Elman was a savant classical violinist known for his passionate tone and virtuosity.
Health promotion meets social marketing: the Monash Preschool Dental Program (MPDP)
Creators: name: Bell, George
name: Hill, Anne C.
name: Hill, Railton M.
Publisher: name: Swinburne
Year: 2024

description: Social marketing principles have long been employed in the field of health promotion, although often without full and strategic inclusion and integration of all elements of the marketing mix. Typically, large population segments are targeted for behavioural change via mass media campaigns. A recent study concluded that while professionals self-identifying as ‘health promoters’ can enhance their effectiveness by such increased strategic inclusion and utilisation of mix elements, they can also offer models of social marketing practice from which other marketers can learn. The Monash Pre-school Dental Program (MPDP) is offered as a case study exemplifying the successful application of a ‘community development’ approach we can recognise as incorporating strong elements of relationship marketing, within social marketing principles. Marketing network theory is suggested as one key framework that may be expanded through further study of such cases. The case exemplifies the mutual learning available between health promoters and other marketers.
Mozambique Data Governance Plan
Creators: name: Jeremias, Iazalde Jose
name: Dos Santos, Imaculada Jose
Publisher: name: Zenodo
Year: 2024

description: Mozambique is advancing towards universal energy access by 2030 by constructing an integrated planning platform. This initiative involves key actors, including the Ministry of Mineral Resources and Energy, grid and off-grid operators, the private sector, the Energy Regulatory Authority, and financiers. To streamline efforts, it is essential to define and communicate the roles of each stakeholder. This will prevent duplicative actions, enhance transparency, and ensure coordinated progress in electrification, fostering collaboration and efficiency in achieving the nation’s energy goals.
title: "Ich habe nichts zu verstecken ... oder doch?!"
title: Ein Praxisleitfaden zur Diskussion in der Klasse
titleType: Subtitle
Creators: name: Schroeder, Romain
Publisher: name: Trier University
Year: 2020
Subjects: subject: Digitalisierung
subject: Demokratie
subject: Schule
subject: Unterrichtsforschung
subject: Neue Medien
subject: Informationsquelle
subject: Internet
subject: digitization
subject: democracy
subject: school
subject: digital media
subject: information source
subject: teaching research
subject: digitalissation
subject: démocratie
subject: école
subject: médias digitaux
subject: source d'information

description: Durch das Zusammenspiel von Big Data und künstlicher Intelligenz eröffnen sich ganz neue Möglichkeiten, auch im Bereich der öffentlichen Sicherheit. Immer mehr Städte weltweit machen davon Gebrauch und setzen auf Kameras mit computergesteuerter Gesichtserkennung. Nicht jeder ist damit einverstanden. Wie kann man die aktuelle gesellschaftliche Debatte um öffentliche Sicherheit und Privatsphäre mit Jugendlichen besprechen?
La théorie de Jean-Daniel Reynaud. Réflexions et souvenirs
Creators: name: Maggi, Bruno
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2020
Subjects: M-PSI/06 Psicologia del lavoro e delle organizzazioni
SECS-P/08 Economia e gestione delle imprese
SECS-P/10 Organizzazione aziendale
SPS/09 Sociologia dei processi economici e del lavoro

description: Reflections on the genesis and developments of the theory of social regulation are intertwined with personal memories of meetings and exchanges of points of view with Jean-Daniel Reynaud. The criticism of the functionalist vision of the organization and regulation of human action stands out. The original characteristics of the sociology of work and their influence on the birth of French ergonomics, the evolutions of the study of work and its changes, the affinities between the theory of social regulation and the theory of organizational action are evoked. Historical reconstructions highlight issues that are still current.
Engaging University Leadership for Gender Equality in STEM
Creators: name: Hunt, M.
name: Devereux, M.
name: Heffernan, E.
name: McKeever, S.
name: Dunne, J.
name: Shoemaker, L.
name: O'Leary, C.
Publisher: name: Zenodo
Year: 2022
Subjects: Women, Science, CBHE, EU, gender, STEM, W-STEM, Latin-America

description: In the context of the W-STEM ERASMUS + Capacity-building in Higher Education European Project (Ref. 598923-EPP-1-2018-1-ES-EPPKA2-CBHE-JP), the W-STEM Chile International Conference was held on 19-20 April 2022 in Valparaíso (Chile), hosted by the Pontificia Universidad Católica de Valparaíso and the Universidad Técnica Federico Santa María, after more than two years working virtually on the global COVID-19 pandemic. This contribution was devoted to present the TU Dublin experience in engaging University Leadership for Gender Equality in STEM.

description: The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
Crystal methamphetamine initiation among street-involved youth
Creators: name: Uhlmann, Sasha
name: DeBeck, Kora
name: Simo, Annick
name: Kerr, Thomas
name: Montaner, Julio
name: Wood, Evan
Publisher: name: Taylor & Francis
Year: 2017

description: Background: Although many settings have recently documented a substantial increase in the use of methamphetamine-type stimulants, recent reviews have underscored the dearth of prospective studies that have examined risk factors associated with the initiation of crystal methamphetamine use. Objectives: Our objectives were to examine rates and risk factors for the initiation of crystal methamphetamine use in a cohort of street-involved youth. Methods: Street-involved youth in Vancouver, Canada, were enrolled in a prospective cohort known as the At-Risk Youth Study (ARYS). A total of 205 crystal methamphetamine-naïve participants were assessed semi-annually and Cox regression analyses were used to identify factors independently associated with the initiation of crystal methamphetamine use. Results: Among 205 youth prospectively followed from 2005 to 2012, the incidence density of crystal methamphetamine initiation was 12.2 per 100 person years. In Cox regression analyses, initiation of crystal methamphetamine use was independently associated with previous crack cocaine use (adjusted relative hazard [ARH] = 2.24 [95% CI: 1.20–4.20]) and recent drug dealing (ARH = 1.98 [95% CI: 1.05–3.71]). Those initiating methamphetamine were also more likely to report a recent nonfatal overdose (ARH = 3.63 [95% CI: 1.65–7.98]) and to be male (ARH = 2.12 [95% CI: 1.06–4.25]). Conclusions: We identified high rates of crystal methamphetamine initiation among this population. Males those involved in the drug trade, and those who used crack cocaine were more likely to initiate crystal methamphetamine use. Evidence-based strategies to prevent and treat crystal methamphetamine use are urgently needed.
Disturbance decoupling with constant measurement feedback for MIMO nonlinear systems
Creators: name: Zheng, Yufan
name: Zhang, Cishen
Publisher: name: Swinburne
Year: 2024

description: The problem of disturbance decoupling with constant measurement feedback (DDPCM) has been studied for single-input single-output and left-invertible multi-input multi-output nonlinear systems. We deal with this problem for more general multi-input multi-output nonlinear systems. Conditions and a computational method for solving the DDPCM are presented in the differential vector space framework.
Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis
Creators: name: Jassem, Agatha N
name: Forbes, Connor M
name: Speert, David P
Publisher: name: BioMed Central
Year: 2016

description: Background: Burkholderia cepacia complex (BCC) bacteria are highly virulent, typically multidrug-resistant, opportunistic pathogens in cystic fibrosis (CF) patients and other immunocompromised individuals. B. vietnamiensis is more often susceptible to aminoglycosides than other BCC species, and strains acquire aminoglycoside resistance during chronic CF infection and under tobramycin and azithromycin exposure in vitro, apparently from gain of antimicrobial efflux as determined through pump inhibition. The aims of the present study were to determine if oxidative stress could also induce aminoglycoside resistance and provide further observations in support of a role for antimicrobial efflux in aminoglycoside resistance in B. vietnamiensis. Findings: Here we identified hydrogen peroxide as an additional aminoglycoside resistance inducing agent in B. vietnamiensis. After antibiotic and hydrogen peroxide exposure, isolates accumulated significantly less [3H] gentamicin than the susceptible isolate from which they were derived. Strains that acquired aminoglycoside resistance during infection and after exposure to tobramycin or azithromycin overexpressed a putative resistance-nodulation-division (RND) transporter gene, amrB. Missense mutations in the repressor of amrB, amrR, were identified in isolates that acquired resistance during infection, and not in those generated in vitro. Conclusions: These data identify oxidative stress as an inducer of aminoglycoside resistance in B. vietnamiensis and further suggest that active efflux via a RND efflux system impairs aminoglycoside accumulation in clinical B. vietnamiensis strains that have acquired aminoglycoside resistance, and in those exposed to tobramycin and azithromycin, but not hydrogen peroxide, in vitro. Furthermore, the repressor AmrR is likely just one regulator of the putative AmrAB-OprM efflux system in B. vietnamiensis.