cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Ecological Network Analysis, indicators of food-web changes in the Baltic Sea
Creators: name: T. Tomczak, Maciej
name: Heymans, Sheila JJ
name: Blenckner, Thorsten
name: Niiranen, Susa
Publisher: name: ASC 2009 - Theme session P
Year: 2024
Subjects: Fisheries and aquaculture
Pressures, impacts, conservation, and management

description: No abstracts are to be cited without prior reference to the author.Long term changes in the Baltic Sea ecosystems have been studied using a food web model based on the software Ecopath with Ecosim. Indices of ecosystem change were calculated by using the ecological network analysis. These indices were tested for decadal regime shifts by using two different methods, the sequential t-test analysis of regime shift (STARS) and chronological cluster analysis. The results indicate that at least one regime shift has occurred over the past 30 years. Our analysis further indicates that changes in physical drivers were not the only cause of regime shifts in the ecosystem, as regime shifts mostly occurred when there was cumulative anthropogenic stressor of fishing and large scale environmental drivers.
Leptin/HER2 crosstalk in breast cancer: In vitro study and preliminary in vivo analysis
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2008
Subjects: Breast Neoplasms
Carcinoma, Ductal, Breast
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Leptin
Obesity
Postmenopause
Protein Binding
Receptor Cross-Talk
Receptor, ErbB-2
Receptors, Leptin
Risk Factors
Transcriptional Activation

description: Background: Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. Some of these effects might be mediated by obesity hormone leptin, acting independently or modulating other signaling pathways. Here we focused on the link between leptin and HER2. We tested if HER2 and the leptin receptor (ObR) can be coexpressed in breast cancer cell models, whether these two receptors can physically interact, and whether leptin can transactivate HER2. Next, we studied if leptin/ObR can coexist with HER2 in breast cancer tissues, and if presence of these two systems correlates with specific clinicopathological features. Methods: Expression of ObR, HER2, phospo-HER2 was assessed by immonoblotting. Physical interactions between ObR and HER2 were probed by immunoprecipitation and fluorescent immunostaining. Expression of leptin and ObR in breast cancer tissues was detected by immunohistochemistry (IHC). Associations among markers studied by IHC were evaluated using Fisher's exact test for count data. Results: HER2 and ObR were coexpressed in all studied breast cancer cell lines. In MCF-7 cells, HER2 physically interacted with ObR and leptin treatment increased HER2 phosphorylation on Tyr 1248. In 59 breast cancers, the presence of leptin was correlated with ObR (the overall association was about 93%). This result was confirmed both in HER2-positive and in HER2-negative subgroups. The expression of leptin or ObR was numerically more frequent in larger (> 10 mm) tumors. Conclusion: Coexpression of HER2 and the leptin/ObR system might contribute to enhanced HER2 activity and reduced sensitivity to anti-HER2 treatments. © 2008 Fiorio et al; licensee BioMed Central Ltd.
title: A Proposed Plan for a General Business Course at Sunset Utah Junior High School For Ninth-Grade Students
Creators: name: Bodily, Renae G.
Publisher: name: Utah State University
Year: 1969

description: According to Maze, "A society that guarantees the social and political freedom of its members, through democratic means, and which extends this freedom into the realm of economics, may be expected to place a heavy responsibility upon its members to protect these freedoms through the exercise of sound choices among alternative means to desired ends." The educational means by which the individual learns of these alternatives must be provided.
title: A Study to Determine the Number, Type, and Requirements of Office Entry-Level Jobs in Ogden, Utah, Banks
Creators: name: Cox, O. Shelby
Publisher: name: Utah State University
Year: 1969

description: This study was undertaken to determine the number, type, and requirements of entry-level office positions in Ogden, Utah, banks.
Questionnaires were taken to the participating banks in the Ogden, Utah, banking community. The responding banks indicated that they would consider recent high school graduates to all of the positions studied; however, a majority of the banks preferred to hire females rather than males to to the office positions studied.
All of the responding banks required some type of requirement for each of the office entry-level positions, and majority of the banks required a pre-employment test of the applicants. This information was put into table form using numbers and percentages as the means of reporting the data.
Recalibrating the KITTI Dataset Camera Setup for Improved Odometry Accuracy
Creators: name: Cvišić, Igor
name: Marković, Ivan
name: Petrović, Ivan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Robotics (cs.RO)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Over the last decade, one of the most relevant public datasets for evaluating odometry accuracy is the KITTI dataset. Beside the quality and rich sensor setup, its success is also due to the online evaluation tool, which enables researchers to benchmark and compare algorithms. The results are evaluated on the test subset solely, without any knowledge about the ground truth, yielding unbiased, overfit free and therefore relevant validation for robot localization based on cameras, 3D laser or combination of both. However, as any sensor setup, it requires prior calibration and rectified stereo images are provided, introducing dependence on the default calibration parameters. Given that, a natural question arises if a better set of calibration parameters can be found that would yield higher odometry accuracy. In this paper, we propose a new approach for one shot calibration of the KITTI dataset multiple camera setup. The approach yields better calibration parameters, both in the sense of lower calibration reprojection errors and lower visual odometry error. We conducted experiments where we show for three different odometry algorithms, namely SOFT2, ORB-SLAM2 and VISO2, that odometry accuracy is significantly improved with the proposed calibration parameters. Moreover, our odometry, SOFT2, in conjunction with the proposed calibration method achieved the highest accuracy on the official KITTI scoreboard with 0.53% translational and 0.0009 deg/m rotational error, outperforming even 3D laser-based methods.
Surrogate model solver for impurity-induced superconducting subgap states
Creators: name: Baran, Virgil V.
name: Frost, Emil J. P.
name: Paaske, Jens
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A simple impurity solver is shown to capture the impurity-induced superconducting subgap states in quantitative agreement with the numerical renormalization group and quantum Monte-Carlo simulations. The solver is based on the exact diagonalization of a single-impurity Anderson model with discretized superconducting reservoirs including only a small number of effective levels. Their energies and couplings to the impurity $d$-level are chosen so as to best reproduce the Matsubara frequency dependence of the hybridization function. We provide a number of critical benchmarks and demonstrate the solvers efficiency in combination with the reduced basis method [Phys. Rev. B 107, 144503 (2023)] by calculating the phase diagram for an interacting three-terminal junction.
description: 19 pages, 20 figures; v2: new results on the phase diagram of a finite-gap interacting topological three-terminal Josephson junction
Frequency Locking of an Optical Cavity using LQG Integral Control
Creators: name: Hassen, S. Z. Sayed
name: Heurs, M.
name: Huntington, E. H.
name: Petersen, I. R.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Quantum Physics (quant-ph)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper considers the application of integral Linear Quadratic Gaussian (LQG) optimal control theory to a problem of cavity locking in quantum optics. The cavity locking problem involves controlling the error between the laser frequency and the resonant frequency of the cavity. A model for the cavity system, which comprises a piezo-electric actuator and an optical cavity is experimentally determined using a subspace identification method. An LQG controller which includes integral action is synthesized to stabilize the frequency of the cavity to the laser frequency and to reject low frequency noise. The controller is successfully implemented in the laboratory using a dSpace DSP board.
description: 18 pages, 9 figures
Single-entity heparan sulfate glycomimetic clusters for therapeutic applications
Creators: name: Tyler, Peter
name: Guimond, SE
name: Turnbull, JE
name: Zubkova, Olga
Publisher: name: Open Access Victoria University of Wellington | Te Herenga Waka
Year: 2021
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences

description: Heparan sulfate (HS) is a highly sulfated glycosaminoglycan with a variety of critical functions in cell signaling and regulation. HS oligosaccharides can mimic or interfere with HS functions in biological systems; however, their exploitation has been hindered by the complexity of their synthesis. Polyvalent displays of small specific HS structures on dendritic cores offer more accessible constructs with potential advantages as therapeutics, but the synthesis of single-entity HS polyvalent compounds has not previously been described. Herein we report the synthesis of a novel targeted library of single-entity glycomimetic clusters capped with varied HS saccharides. They have the ability to mimic longer natural HS saccharides in their inhibition of the Alzheimer's disease (AD) protease BACE-1. We have identified several single-entity HS clusters with IC50 values in the low-nanomolar range. These HS clusters are drug leads for AD and offer a novel framework for the manipulation of heparan sulfate-protein interactions in general.
The search for intermodulation coupling in the ground
Creators: name: Mitchell, Gerald George
Publisher: name: University of British Columbia
Year: 2010

description: The assumption that the ground behaves as a linear electrical network is tested with a field experiment. Two sinusoids of current are transmitted into the ground simultaneously. The potential field is measured and recorded on magnetic tape. Amplitude spectra are computed and searched for intermodulation coupling terms, the presence of which indicate nonlinearity. Tests on the UBC campus did not detect intermodulation coupling. The first test, at a volcanogenic massive sulfide deposit, indicated significent intermodulation coupling. This test was repeated with a different instrument-electrode configuration. There was no coupling detected in the repeated test.
title: Ujawnienie w księdze wieczystej prawa dożywocia
Creators: name: Gniewek, Edward
Publisher: name: E-Wydawnictwo. Prawnicza i Ekonomiczna Biblioteka Cyfrowa. Wydział Prawa, Administracji i Ekonomii Uniwersytetu Wrocławskiego
Year: 2019

description: W stosunku prawnym dożywocia, nawiązywanym na podstawie umowy dożywocia, następuje ustanowienie prawa dożywocia w zamian za przeniesienie własności nieruchomości. W zasadniczej mierze status prawa dożywocia określono w materialnoprawnej regulacji kodeksu cywilnego. Określono tam uprawnienia dożywotnika, w powiązaniu z treścią ciężarów zobowiązanego (art. 908 k.c.). W tej kodeksowej regulacji przyjęto konstrukcję rozszerzonej skuteczności ustanowionego prawa dożywocia wobec kolejnego właściciela nieruchomości. Równocześnie zaś w odrębnej regulacji ustawy o księgach wieczystych i hipotece dopuścił ustawodawca (w art. 16 ust. 2 pkt 1) ujawnienie prawa dożywocia w księdze wieczystej jako prawa osobistego (względnego). Jego wpis, fakultatywny, ma charakter deklaratoryjny. Ujawnieniu podlega ustanowione prawo (dożywocia), ze wskazaniem jego treści i przedmiotu. Dokonanie wpisu bynajmniej nie oznacza przekształcenia ujawnionego prawa dożywocia w ograniczone prawo rzeczowe. Udzieleniu istotnej, zewnętrznej ochrony prawa dożywocia służy zastosowana, kodeksowa konstrukcja jego rozszerzonej skuteczności, niezależnej od wpisu w księdze wieczystej. Natomiast dokonanie wpisu służy pełnemu ujawnieniu stanu prawnego nieruchomości.
Development and notch signaling requirements of the zebrafish choroid plexus
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2008
Subjects: Animals
Biological Transport
Blood-Brain Barrier
Brain
Choroid Plexus
Epithelium
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Microscopy, Fluorescence
Models, Biological
Receptors, Notch
Signal Transduction
Zebrafish
Zebrafish Proteins

description: Background: The choroid plexus (CP) is an epithelial and vascular structure in the ventricular system of the brain that is a critical part of the blood-brain barrier. The CP has two primary functions, 1) to produce and regulate components of the cerebral spinal fluid, and 2) to inhibit entry into the brain of exogenous substances. Despite its importance in neurobiology, little is known about how this structure forms. Methodology and Principal Findings: Here we show that the transposon-mediated enhancer trap zebrafish line EtMn16 expresses green fluorescent protein within a population of cells that migrate toward the midline and coalesce to form the deifinitive CP. We further demonstrate the development of the integral vascular network of the definitive CP. Utilizing pharmacologic pan-notch inhibition and specific morpholino-mediated knockdown, we demonstrate a requirement for Notch signaling in choroid plexus development. We identify three Notch signaling pathway members as mediating this effect, notch1b, deltaA and deltaD. Conclusions and Significance: This work is the first to identify the zebrafish choroid plexus and to characterize its epithelial and vasculatre integration. This study, in the context of other comparative anatomical studies, strongly indicates a conserved mechanism for development of the CP. Finally, we characterize a requirement for Notch signaling in the developing CP. This establishes the zebrafish CP as an important new system for the determination of key signaling pathways in the formation of this essential component of the vertebrate brain. © 2008 Bill et al.
title: Formulation of a Mathematical Model for the Allocation of Colorado River Waters in Utah
Creators: name: Gold, Rick L.
Publisher: name: Utah State University
Year: 1969

description: This report is linked with the work done in fulfillment of the first objective of a research project now underway at the Utah Water Research Laboratory. The project, entitled "Application of Operations Research Techniques for Allocation of Colorado River Waters in Utah," is a matching fund grant by The Office of Water Resources Research of the United States Department of the Interior. The project has the following objectives: (1) formulate the mathematical model of that part of the state that can receive Colorado River water, (2) optimize the allocation model under different demand levels and study the economic effects of legal, political, and social limitations, (3) evaluate the usefulness of the operations research approach for water planning.
Preprocessing and Modeling of Radial Fan Data for Health State Prediction
Creators: name: Holzinger, Florian
name: Kommenda, Michael
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Monitoring critical components of systems is a crucial step towards failure safety. Affordable sensors are available and the industry is in the process of introducing and extending monitoring solutions to improve product quality. Often, no expertise of how much data is required for a certain task (e.g. monitoring) exists. Especially in vital machinery, a trend to exaggerated sensors may be noticed, both in quality and in quantity. This often results in an excessive generation of data, which should be transferred, processed and stored nonetheless. In a previous case study, several sensors have been mounted on a healthy radial fan, which was later artificially damaged. The gathered data was used for modeling (and therefore monitoring) a healthy state. The models were evaluated on a dataset created by using a faulty impeller. This paper focuses on the reduction of this data through downsampling and binning. Different models are created with linear regression and random forest regression and the resulting difference in quality is discussed.
description: International Conference on Computer Aided Systems Theory, Eurocast 2019, pp 312-318
Running sums for $2νββ$-decay matrix elements within the QRPA with account for deformation
Creators: name: Fang, Dongliang
name: Faessler, Amand
name: Rodin, Vadim
name: Yousef, Mohamed Saleh
name: Simkovic, Fedor
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The $2νββ$-decay running sums for $^{76}$Ge and $^{150}$Nd nuclei are calculated within a QRPA approach with account for deformation. A realistic nucleon-nucleon residual interaction based on the Brueckner G matrix (for the Bonn CD force) is used. The influence of different model parameters on the functional behavior of the running sums is studied. It is found that the parameter $g_{pp}$ renormalizing the G matrix in the QRPA particle-particle channel is responsible for a qualitative change in behavior of the running sums at higher excitation energies. For realistic values of $g_{pp}$ a significant negative contribution to the total $2νββ$-decay matrix element is found to come from the energy region of the giant Gamow-Teller resonance. This behavior agrees with the results of other authors.
description: 4 pages, 2 figures, to be published in PRC
Reconstructing the potential configuration in a high-mobility semiconductor heterostructure with scanning gate microscopy
Creators: name: Percebois, Gaëtan J.
name: Lacerda-Santos, Antonio
name: Brun, Boris
name: Hackens, Benoit
name: Waintal, Xavier
name: Weinmann, Dietmar
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The weak disorder potential seen by the electrons of a two-dimensional electron gas in high-mobility semiconductor heterostructures leads to fluctuations in the physical properties and can be an issue for nanodevices. In this paper, we show that a scanning gate microscopy (SGM) image contains information about the disorder potential, and that a machine learning approach based on SGM data can be used to determine the disorder. We reconstruct the electric potential of a sample from its experimental SGM data and validate the result through an estimate of its accuracy.
description: 23 pages, 12 figures, Submission to SciPost
MOESM11 of A simple and cost-effective method for screening of CRISPR/Cas9-induced homozygous/biallelic mutants
Creators: name: Guo, Jinggong
name: Li, Kun
name: Jin, Lifeng
name: Xu, Rui
name: Miao, Kaiting
name: Yang, Fengbo
name: Qi, Chaoya
name: Zhang, Lin
name: Botella, Jose
name: Wang, Ran
name: Miao, Yuchen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Additional file 11: Fig.Â 9. Identification of CRISPR/Cas9-induced rin4 mutants in tobacco by MSBSP-PCR.
Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2008
Subjects: Animals
Evolution, Molecular
Genes, Viral
Humans
Indonesia
Influenza A Virus, H5N1 Subtype
Influenza in Birds
Poultry
Poultry Diseases

description: H5N1 highly pathogenic avian influenza (HPAI) viruses have seriously affected the Asian poultry industry since their recurrence in 2003. The viruses pose a threat of emergence of a global pandemic influenza through point mutation or reassortment leading to a strain that can effectively transmit among humans. In this study, we present phylogenetic evidences for the interlineage reassortment among H5N1 HPAI viruses isolated from humans, cats, and birds in Indonesia, and identify the potential genetic parents of the reassorted genome segments. Parsimony analyses of viral phylogeography suggest that the reassortant viruses may have originated from greater Jakarta and surroundings, and subsequently spread to other regions in the West Java province. In addition, Bayesian methods were used to elucidate the genetic diversity dynamics of the reassortant strain and one of its genetic parents, which revealed a more rapid initial growth of genetic diversity in the reassortant viruses relative to their genetic parent. These results demonstrate that interlineage exchange of genetic information may play a pivotal role in determining viral genetic diversity in a focal population. Moreover, our study also revealed significantly stronger diversifying selection on the M1 and PB2 genes in the lineages preceding and subsequent to the emergence of the reassortant viruses, respectively. We discuss how the corresponding mutations might drive the adaptation and onward transmission of the newly formed reassortant viruses. © 2008 Lam et al.
title: Graduate Recital
Creators: name: Peterson, Gerald Graham
Publisher: name: Utah State University
Year: 1969

description: For several years the writer had considered the idea that being an accomplished performer would be challenging and stimulating. He had been in public school music instruction and unable to develop this idea to the point that he would like. After his decision to work on a Master 's Degree in music, the thought of performing a recital was greeted as a welcome experience.
Certain aspects had to be considered before actual practice on a recital could begin. When planning a program to present for the recital, two facts came to mind. The writer had played the clarinet for 16 years and had experience in many bands and solo performances for region contests. The writer also had experience on the flute, bass clarinet, saxophone, and oboe. It was decided that the B~ clarinet would be the major performing instrument. Because of the limited practice time over the past two years on the flute, oboe, and saxophone, it was decided in conference with Dr. Max F. Dalby that the bass clarinet would provide a desirable companion. The contrast of sound between the B~ and the bass clarinet lent variety to the program.
Selection of music then had to be made. Certain criteria had to be met by this literature to provide the performer stimulation, interest and intellectual growth. Again Dr. Dalby was consulted and a decision was made as to which pieces would best meet these criteria.
title: Graduate Recital
Creators: name: Williams, Marilyn J.
Publisher: name: Utah State University
Year: 1969

description: The master's recital in piano customarily includes works from the Baroque, Classic, Romantic, and Twentieth Century Periods, The recital presented has conformed to these requirements with works by Bach , Beethoven, Chopin, and Debussy.
The partita, sonata, and nocturne represent musical forms which reached their ultimate development in the works of Bach , Beethoven, and Chopin, respectively, during the periods in which they were composed. So great was the genius of these composers that their names will always be intimately associated with these musical forms. whereas the preceding forms were climaxed by the compositions of Bach, Beethoven, and Chopin, Debussy originated Impressionism in music.
The evolution of the partita, sonata, nocturne, and Impressionism comprises a significant and interesting milestone in musical history. The following discussion describes the historical development of these forms with particular emphasis on the specific contribution through which the composer brought everlasting greatness to the form.
Understanding and Preparing Data of Industrial Processes for Machine Learning Applications
Creators: name: Fleck, Philipp
name: Kügel, Manfred
name: Kommenda, Michael
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Industrial applications of machine learning face unique challenges due to the nature of raw industry data. Preprocessing and preparing raw industrial data for machine learning applications is a demanding task that often takes more time and work than the actual modeling process itself and poses additional challenges. This paper addresses one of those challenges, specifically, the challenge of missing values due to sensor unavailability at different production units of nonlinear production lines. In cases where only a small proportion of the data is missing, those missing values can often be imputed. In cases of large proportions of missing data, imputing is often not feasible, and removing observations containing missing values is often the only option. This paper presents a technique, that allows to utilize all of the available data without the need of removing large amounts of observations where data is only partially available. We do not only discuss the principal idea of the presented method, but also show different possible implementations that can be applied depending on the data at hand. Finally, we demonstrate the application of the presented method with data from a steel production plant.
description: International Conference on Computer Aided Systems Theory, Eurocast 2019, pp 413-420
DeSCo: Towards Generalizable and Scalable Deep Subgraph Counting
Creators: name: Fu, Tianyu
name: Wei, Chiyue
name: Wang, Yu
name: Ying, Rex
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences
subject: I.2.8

description: We introduce DeSCo, a scalable neural deep subgraph counting pipeline, designed to accurately predict both the count and occurrence position of queries on target graphs post single training. Firstly, DeSCo uses a novel canonical partition and divides the large target graph into small neighborhood graphs, greatly reducing the count variation while guaranteeing no missing or double-counting. Secondly, neighborhood counting uses an expressive subgraph-based heterogeneous graph neural network to accurately count in each neighborhood. Finally, gossip propagation propagates neighborhood counts with learnable gates to harness the inductive biases of motif counts. DeSCo is evaluated on eight real-world datasets from various domains. It outperforms state-of-the-art neural methods with 137x improvement in the mean squared error of count prediction, while maintaining the polynomial runtime complexity. Our open source project is at https://github.com/fuvty/DeSCo.
description: 8 pages main text, 2 pages references, 11 pages appendix; open source at https://github.com/fuvty/DeSCo
Continuing trastuzumab beyond disease progression: Outcomes analysis in patients with metastatic breast cancer
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2008
Subjects: Adult
Aged
Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Antineoplastic Agents
Breast Neoplasms
Disease Progression
Disease-Free Survival
Female
Humans
In Situ Hybridization, Fluorescence
Middle Aged
Neoplasm Metastasis
Retrospective Studies
Trastuzumab
Treatment Outcome

description: Introduction: We performed a retrospective analysis of HER2-overexpressing metastatic breast cancer patients to describe clinical outcomes of those who, despite progression of the disease (PD), maintained trastuzumab for multiple chemotherapy lines. We also compared survival of these patients with that of those who halted trastuzumab at first PD.Methods: We identified 101 patients treated between July 2000 and January 2007. Nineteen were still receiving the first-line trastuzumab-based treatment without evidence of PD and were not included in this analysis. Of the remaining 82 patients, 59 retained trastuzumab for one or more additional lines of chemotherapy after PD, according to our institution policy. Twenty-three patients who changed treating institution and stopped trastuzumab at first progression were used as a control group.Results: For patients retaining trastuzumab, the median follow-up was 39.6 months. Clinical outcomes showed the typical degradation between first and second lines of therapy which we would expect by halting trastuzumab at first progression. Response rates were 35% and 16% and median times to progression were 7.25 and 5.25 months for the first and second lines of trastuzumab therapy, respectively. The median overall survival (OS) rates were 70 months for patients who retained trastuzumab and 56 months for patients who halted the drug (hazard ratio [HR] 0.87, 95% confidence interval [CI] 0.51 to 1.18; P = 0.52). If we consider OS from the start of trastuzumab therapy, the figures are 53.9 and 34.8 months, respectively (HR 0.78, 95% CI 0.58 to 1.32; P = 0.2).Conclusion: A nonstatistically significant trend of improved survival for patients retaining trastuzumab is observed. This is in line with most retrospective analyses and recent randomized data. Retaining trastuzumab after progression is a reasonable option, but further randomized data are warranted to better define its role in comparison with other available options. © 2008 Cancello et al.; licensee BioMed Central Ltd.
title: Graduate Recital
Creators: name: Bertolio, William D.
Publisher: name: Utah State University
Year: 1970

description: The candidate selected the recital and recital report as the master's project on the basis that they would effectively improve his musicianship, as well as bolster his teaching background, performance skills, teaching techniques, and general musical knowledge.
The recital included one major work on the B-flat clarinet , an alto saxophone solo, a clarinet quartet, and a woodwind trio. In addition, clarinet and saxophone solos were performed by two of the writer's advanced students. The compositions were chosen because of their musical value and variety.
The performer's experience included nine years of private instruction on the clarinet, eight years of teaching individual clarinet and saxophone, and one year of private instruction on the saxophone. This background experience was an important consideration in the selection of the program.
The candidate considered it advisable 1.0 use four of his private students on the recital in order to demonstrate teaching concepts . Because much of the candidate's future success as a teacher will rely on his mastery as a performer, most of the preparation time was devoted to the performance of the major work for clarinet.
It was the goal of the candidate to realize a rewarding and worthwhile experience both in the preparation and performance of this project. The writer felt the experience was stimulating, as well as cha llenging, and resulted in a sense of personal pride and satisfaction.
Proof-of-Reputation: An Alternative Consensus Mechanism for Blockchain Systems
Creators: name: Aluko, Oladotun
name: Kolonin, Anton
Publisher: name: arXiv
Year: 2021
Subjects: subject: Social and Information Networks (cs.SI)
subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: Blockchains combine other technologies, such as cryptography, networking, and incentive mechanisms, to enable the creation, validation, and recording of transactions between participating nodes. A consensus algorithm is used in a blockchain system to determine the shared state among distributed nodes. An important component underlying any blockchain-based system is its consensus mechanism, which principally determines the performance and security of the overall system. As the nature of peer-to- peer(P2P) networks is open and dynamic, the security risk within that environment is greatly increased mostly because nodes can join and leave the network at will. Thus, it is important to have a system that can check against malicious behaviour. In this work, we propose a reputation-based consensus mechanism for blockchain-based systems, Proof-of-Reputation(PoR) where the nodes with the highest reputation values eventually become part of a consensus group that determines the state of the blockchain.
Mean-field Coherent Ising Machines with artificial Zeeman terms
Creators: name: Gunathilaka, Mastiyage Don Sudeera Hasaranga
name: Inui, Yoshitaka
name: Kako, Satoshi
name: Yamamoto, Yoshihisa
name: Aonishi, Toru
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Coherent Ising Machine (CIM) is a network of optical parametric oscillators that solves combinatorial optimization problems by finding the ground state of an Ising Hamiltonian. In CIMs, a problem arises when attempting to realize the Zeeman term because of the mismatch in size between interaction and Zeeman terms due to the variable amplitude of the optical parametric oscillator pulses corresponding to spins. There have been three approaches proposed so far to address this problem for CIM, including the absolute mean amplitude method, the auxiliary spin method, and the chaotic amplitude control (CAC) method. This paper focuses on the efficient implementation of Zeeman terms within the mean-field CIM model, which is a physics-inspired heuristic solver without quantum noise. With the mean-field model, computation is easier than with more physically accurate models, which makes it suitable for implementation in field programmable gate arrays (FPGAs) and large-scale simulations. Firstly, we examined the performance of the mean-field CIM model for realizing the Zeeman term with the CAC method, as well as their performance when compared to a more physically accurate model. Next, we compared the CAC method to other Zeeman term realization techniques on the mean-field model and a more physically accurate model. In both models, the CAC method outperformed the other methods while retaining similar performance.
description: 8 pages, 4 figures
MANAGING THE COVID-19 PANDEMIC IN ECONOMICALLY CHALLENGED AREAS
Creators: name: Dr. Helen, Carter
name: Dr. Michael, Kimani, Ph.D
name: Dr. Laura, Thompson
Publisher: name: AYDEN JOURNAL
Year: 2024
Subjects: COVID-19, pandemic, SARS-CoV-2, global response, containment measures

description: In early 2020, a novel flu-like illness, later named Coronavirus Disease (COVID-19), emerged and began to spread globally. It posed a significant threat to the elderly and those with underlying health conditions, leading governments worldwide to implement various containment measures. These measures ranged from restricting air travel to imposing lockdowns, with Italy becoming an epicenter for the virus in March 2020. The rapid and asymmetrical transmission of the virus raised concerns, making nursing homes and cruise ships particularly vulnerable to outbreaks.

The World Health Organization and global health experts identified the illness as a severe acute respiratory syndrome caused by the novel virus, SARS-CoV-2. This virus could be transmitted in aerosolized form and had a wide incubation period. Understanding the dynamics of the COVID-19 pandemic and its impact on different regions and demographics became crucial for public health responses
A Bottom-up method Towards the Automatic and Objective Monitoring of Smoking Behavior In-the-wild using Wrist-mounted Inertial Sensors
Creators: name: Kirmizis, Athanasios
name: Kyritsis, Konstantinos
name: Delopoulos, Anastasios
Publisher: name: arXiv
Year: 2021
Subjects: subject: Signal Processing (eess.SP)
subject: Machine Learning (cs.LG)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: The consumption of tobacco has reached global epidemic proportions and is characterized as the leading cause of death and illness. Among the different ways of consuming tobacco (e.g., smokeless, cigars), smoking cigarettes is the most widespread. In this paper, we present a two-step, bottom-up algorithm towards the automatic and objective monitoring of cigarette-based, smoking behavior during the day, using the 3D acceleration and orientation velocity measurements from a commercial smartwatch. In the first step, our algorithm performs the detection of individual smoking gestures (i.e., puffs) using an artificial neural network with both convolutional and recurrent layers. In the second step, we make use of the detected puff density to achieve the temporal localization of smoking sessions that occur throughout the day. In the experimental section we provide extended evaluation regarding each step of the proposed algorithm, using our publicly available, realistic Smoking Event Detection (SED) and Free-living Smoking Event Detection (SED-FL) datasets recorded under semi-controlled and free-living conditions, respectively. In particular, leave-one-subject-out (LOSO) experiments reveal an F1-score of 0.863 for the detection of puffs and an F1-score/Jaccard index equal to 0.878/0.604 towards the temporal localization of smoking sessions during the day. Finally, to gain further insight, we also compare the puff detection part of our algorithm with a similar approach found in the recent literature.
description: Manuscript accepted to be published in the 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2021. Acceptance date: 16-July-2021
QED peripheral mechanism of pair production at colliders
Creators: name: Ahmadov, A. I.
name: Galynskii, M. V.
name: Bystritskiy, Yu. M.
name: Kuraev, E. A.
name: Shatnev, M. G.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Cross section of the processes of neutral pion production as well as pairs of charged fermions and bosons in peripherical interaction of leptons, photons are calculated in main logarithmical approximation. We investigate the phase volumes and differential cross sections. The differential cross section of few neutral pions and a few pairs production are written down explicitly. Considering the academic problem of summation on the number of pairs for the case of massless particles we reproduce the known results obtained in seventies of last century. The possibility to construct the generator for Monte-Carlo modeling of this processes basing of this results are discussed.
description: 25 pages, 5 figures
Characterizing gene family evolution
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2008
Subjects: genomics
evolution
molecular
phylogeny
sequence homology

description: Gene families are widely used in comparative genomics, molecular evolution, and in systematics. However, they are constructed in different manners, their data analyzed and interpreted differently, with different underlying assumptions, leading to sometimes divergent conclusions. In systematics, concepts like monophyly and the dichotomy between homoplasy and homology have been central to the analysis of phylogenies. We critique the traditional use of such concepts as applied to gene families and give examples of incorrect inferences they may lead to. Operational definitions that have emerged within functional genomics are contrasted with the common formal definitions derived from systematics. Lastly, we question the utility of layers of homology and the meaning of homology at the character state level in the context of sequence evolution. From this, we move forward to present an idealized strategy for characterizing gene family evolution for both systematic and functional purposes, including recent methodological improvements.
The $q-$state Potts model from the Nonperturbative Renormalization Group
Creators: name: Sánchez-Villalobos, Carlos A.
name: Delamotte, Bertrand
name: Wschebor, Nicolás
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the $q$-state Potts model for $q$ and the space dimension $d$ arbitrary real numbers using the Derivative Expansion of the Nonperturbative Renormalization Group at its leading order, the local potential approximation (LPA and LPA'). We determine the curve $q_c(d)$ separating the first ($q>q_c(d)$) and second ($q
description: 21 pages, 10 figures. The source file includes Supplementary Material
Role of Chaplygin gas as geometrical dark energy in anisotropic brane gravity
Creators: name: Heydari-Fard, Malihe
name: Sepangi, Hamid R.
Publisher: name: arXiv
Year: 2008
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider an anisotropic brane-world model with Bianchi type I and V geometry, without mirror symmetry or any form of junction conditions. The generalized Chaplygin gas, which interpolates between a high density relativistic era and a non-relativistic matter phase, is a popular candidate for the present accelerated expansion of the universe. Considering the generalized Chaplygin gas as a geometrical dark energy, we obtain the general solutions in an exact parametric form for both Bianchi type I and V space-times. Finally, we study the behavior of the observationally important parameters such as the shear, anisotropic and deceleration parameter in this model.
description: 12 pages, 4 figures
title: An Experiment in Orchestration: Prelude an Original Composition for Symphonic Band
Creators: name: Edvalson, Melvin
Publisher: name: Utah State University
Year: 1970

description: From ancient times to the present, music has been composed for instrumental combinations as well as for single instruments. The manner in which these combinations were utilized depended upon current compositional practices, especially those regarding form. In the Baroque Period instrumental ensembles were formed according to the composer's discretion. The tone color embodiment of a particular musical work was set more by the composer's choice of instruments to be included in the ensemble than in his use of instruments as independent tone color sources . The Baroque composer's use of instrumental color was in this way consistent with his use of highly integrated movements, which lacked sharp contrasts, a feeling of periodicity, or antecedent-consequent phrasing. The sustaining of one mood throughout an entire movement was accomplished compositionally through the elaboration of the theme in sequential repetitions of the phrases, and orchestrationally through full ensemble scoring.
The Classical Period's concept of form was similarly reflected in its orchestrational technique. Larger works were organized into contrasting movements. These movements, in turn, were comprised of contrasting sections which themselves contained contrasting elements. A sense of unity Has maintained, in part , through the balancing of the movements within the larger work . This defining of the elements of form through the juxtaposition of contrasting phrases, sections and movements brought with it the juxtaposition of contrasting tone colors. Tone color now changed in phrase lengths. These changes served to highlight the formal elements.
In the Romantic Period the regularity of the formal aspects diminished. The desire for contrast, however, remained and received new emphasis. The tone color was changed more freely and came to be considered an element or the composition rather than something which came after, and was therefore dependent upon, the composition. Impressionism placed such importance upon the change of instrumental tone color that it could stand as the dominant element of a composition. More recently, serial composers have sought to control t one color in the same marmer as they control pitch, dynamics range and expression, so that tone color might be made to change with each note.
It can be seen, then, that through the course of recent musical history, the element of changing tone color has become more independent of other compositional aspects and that the composers of each historical period increased the rate of tone color change. While this historical precedent does not make further growth in this direction valid, it does indicate that further development in the direction of tone color independence and a further increase in the rate of change of tone color might be sought after at this time.
Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2008
Subjects: Amino Acid Motifs
Amino Acid Sequence
Animals
Binding Sites
Computational Biology
Conserved Sequence
Databases, Protein
Humans
Protein-Serine-Threonine Kinases
Proteins
Sequence Analysis, Protein
Sequence Homology, Amino Acid
Structure-Activity Relationship
src Homology Domains

description: Background: Protein interactions are essential for most cellular functions. Interactions mediated by domains that appear in a large number of proteins are of particular interest since they are expected to have an impact on diversities of cellular processes such as signal transduction and immune response. Many well represented domains recognize and bind to primary sequences less than 10 amino acids in length called Short Linear Motifs (SLiMs). Results: In this study, we systematically studied the evolutionary conservation of SLiMs recognized by SH2, SH3 and Ser/Thr Kinase domains in both ordered and disordered protein regions. Disordered protein regions are protein sequences that lack a fixed three-dimensional structure under putatively native conditions. We find that, in all these domains examined, SLiMs are more conserved in disordered regions. This trend is more evident in those protein functional groups that are frequently reported to interact with specific domains. Conclusion: The correlation between SLiM conservation with disorder prediction demonstrates that functional SLiMs recognized by each domain occur more often in disordered as compared to structured regions of proteins. © 2008 Ren et al; licensee BioMed Central Ltd.