cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Why KPIs Don't Work; And How To Fix Them
Creators: name: Vaghela, Shreyansh
Publisher: name: Zenodo
Year: 2023
Subjects: organizational goals, KPIs, performance management, digital-era leadership, customer value, stakeholder engagement, goal alignment, bureaucratic structures, measurement challenges, trust, collaboration, customer-centric, strategic direction, data analysis, insights, recognition system, feedback loop, iterative improvement, employee engagement, dynamic business landscape

description: The article critiques traditional Key Performance Indicators (KPIs) by highlighting their misalignment with unclear organizational goals, leading to bureaucratic structures and ineffective measurements. It advocates for a shift towards digital-era leadership, focusing on delivering value to external customers and using external measures for KPIs.
Adult pertussis vaccination strategies and their impact on pertussis in the United States: evaluation of routine and targeted (cocoon) strategies
Creators: name: ANDRE, P.
name: VAN RIE, A.
name: COUDEVILLE, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: A compartmental, age-structured mathematical model was developed and recent US pertussis epidemiology data were used to evaluate the impact on pertussis infection rates of routine and targeted adult immunization strategies. Model simulations predict that the implementation of adolescent immunization only could reverse the current rise in pertussis infection rates but may lead to a resurgence of pertussis in subsequent decades. In contrast, inclusion of a routine adult strategy is likely to lead to sustained control of pertussis. Routine adult vaccination could control the disease even with relatively low coverage rates of 40% for routine vaccination of all adults every 10 years, or 65% for a targeted vaccination of close contacts of newborns completed by one booster dose for all adults. The model also predicts that the optimal age for this booster dose is 40 years. These results support the 2006 American Academy of Immunization Practices' recommendations for adolescent and adult vaccination against pertussis.
Collaborative composition for musical robots
Creators: name: Kapur, Ajay
name: Eigenfeldt, Arne
name: Bahn, Curtis
name: Schloss, W. Andrew
Publisher: name: Journal of Science and Technology of the Arts
Year: 2009

description: The goal of this research is to collaborate with a number of different artists to explore the capabilities of robotic musical instruments to cultivate new music. This paper describes the challenges faced in using musical robotics in rehearsals and on the performance stage. It also describes the design of custom software frameworks and tools for the variety of composers and performers interacting with the new instruments. Details of how laboratory experiments and rehearsals moved to the concert hall in a variety of diverse performance scenarios are described. Finally, a paradigm for how to teach musical robotics as a multimedia composition course is discussed.
description: Journal of Science and Technology of the Arts, v. 1 n. 1 (2009)
Case studies in live electronic music preservation: recasting Jorge Peixinho's Harmónicos (1967-1986) and Sax-Blue (1984-1992)
Creators: name: Dias, António De Sousa
Publisher: name: Journal of Science and Technology of the Arts
Year: 2009

description: We present two examples of technology transfer from analogical to digital systems, in two works of live electroacoustic music by the Portuguese composer Jorge Peixinho (1940-1995), Harmónicos (1967) and Sax-Blue (1982). These works require the use of analogue technology that has become obsolete or difficult to access by the average performer. We think that migration from electronics to software, also referred as recast represents a necessary step to preserve live electroacoustic music. However, this process can pose multiple questions as it also relies on aesthetic considerations. In this case, we put on a considerable effort into understanding both the composer's intentions and the equipment operating mode and we think the solutions proposed are adequate to perform both works. Finally, we discuss some of the questions, solutions and limitations that arose with these recasts and how they can contribute to the sustainability problem concerning these works.
description: Journal of Science and Technology of the Arts, v. 1 n. 1 (2009)
(195) James How
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Fundamentals and principles of musical telepresence
Creators: name: Carôt, Alexander
name: Werner, Christian
Publisher: name: Journal of Science and Technology of the Arts
Year: 2009

description: The idea of playing livemusic with someone abroad represents a major challenge for musicians and sound engineers likewise. Cognitive, technical and purely musical aspects make high demands on a network music performance that should fulfill conditions of a realistic rehearsing scenarios in the same room. In turn the idea of a network music performance has generally been considered as an impracticable application. However, a precise and comprehensive analysis has so far not been published, which equally issue_covers technical, cognitive aspects and their interdependencies equally. In order to give a final and valid statement about the feasibility of distributed real time music we take any of such relevant aspect into consideration and explain it accordingly to the reader. Finally we conclude that in recent wide area networks remote music sessions are possible assuming an awareness of latency conditions and appropriate interaction categories.
description: Journal of Science and Technology of the Arts, v. 1 n. 1 (2009)
The observed radio/gamma-ray emission correlation for blazars with the Fermi-LAT and the RATAN-600 data
Creators: name: Mufakharov, T.
name: Mingaliev, M.
name: Sotnikova, Yu.
name: Naiden, Ya.
name: Erkenov, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the correlation between gamma-ray and radio band radiation for 123 blazars, using the Fermi-LAT first source catalog (1FGL) and the RATAN-600 data obtained at the same period of time (within a few months). We found an apparent positive correlation for BL Lac and flat-spectrum radio quasar (FSRQ) sources from our sample through testing the value of the Pearson product-moment correlation coefficient. The BL Lac objects show higher values of the correlation coefficient than FSRQs at all frequencies, except 21.7 GHz, and at all bands, except $10-100$ GeV, typically at high confidence level (> 99%). At higher gamma-ray energies the correlation weakens and even becomes negative for BL Lacs and FSRQs. For BL Lac blazars, the correlation of the fluxes appeared to be more sensitive to the considered gamma-ray energy band, than to the frequency, while for FSRQ sources the correlation changed notably both with the considered radio frequency and gamma-ray energy band. We used a data randomization method to quantify the significance of the computed correlation coefficients. We find that the statistical significance of the correlations we obtained between the flux densities at all frequencies and the photon flux in all gamma-ray bands below 3 GeV is high for BL Lacs (chance probability $\sim 10^{-3} - 10^{-7}$). The correlation coefficient is high and significant for the $0.1-0.3$ GeV band and low and insignificant for the $10-100$ GeV band for both types of blazars for all considered frequencies.
description: 14 pages, 5 tables, 8 figures, accepted to MNRAS
Failure to detect infection by oral polio vaccine virus following natural exposure among inactivated polio vaccine recipients
Creators: name: SESSIONS, W.
name: SMITH, B.
name: GARY, H. E.
name: JENKS, J.
name: VINJE, J.
name: SOBSEY, M.
name: RUIZ, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: While oral polio vaccine (OPV) has been shown to be safe and effective, it has been observed that it can circulate within a susceptible population and revert to a virulent form. Inactivated polio vaccine (IPV) confers protection from paralytic disease, but provides limited protection against infection. It is possible, then, that an IPV-immunized population, when exposed to OPV, could sustain undetected circulation of vaccine-derived poliovirus. This study examines the possibility of polio vaccine virus circulating within the United States (highly IPV-immunized) population that borders Mexico (OPV-immunized). A total of 653 stool and 20 sewage samples collected on the US side of the border were tested for the presence of poliovirus. All samples were found to be negative. These results suggest that the risk of circulating vaccine-derived poliovirus is low in fully immunized IPV-using populations in developed countries that border OPV-using populations.
The interactive potential of post-modern film narrative: frequency, order and simultaneity
Creators: name: Caires, Carlos Sena
Publisher: name: Journal of Science and Technology of the Arts
Year: 2009

description: A considerable number of contemporary films are now using narrative models that allow several adaptations on digital and interactive operating systems. This trend is seen in films such as Memento by Christopher Nolan (2000), Irréversible by Gaspar Noé (2002) and Smoking / No Smoking by Alain Resnais (1993), concerning the chronological organization of their narrative parts – here it is a question of order. Or in films such as Elephant by Gus Van Sant (2003), Groundhog Day by Harold Ramis, 1993 and Rashômon by Akira Kurosawa (1950), for the diegetic repetition – a question of frequency. Or even, in films such as Magnolia by Paul Thomas Anderson (1999) and Short Cuts by Robert Altman, 1993 which use the idea of expansion or compression of the narrative – a question of simultaneity. To change the accessibility of the cinematographic experience and to constantly re-evaluate the way in which the narrative tool is used, is from now on considered the interactive potential of the contemporary film narrative.
description: Journal of Science and Technology of the Arts, v. 1 n. 1 (2009)
Low prevalence of HIV and other selected sexually transmitted infections in 2004 in pregnant women from Kinshasa, the Democratic Republic of the Congo
Creators: name: SMITH, J. S.
name: HEMINGWAY-FODAY, J.
name: KOCH, M. A.
name: TSHEFU, A.
name: ATIBU, J.
name: BARTZ, J.
name: RYDER, R. W.
name: HOBBS, M.
name: KINOSHITA-MOLEKA, R.
name: RIMOIN, A. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: This study examined the prevalence of HIV and other sexually transmitted infections (STIs) in pregnant women in Kinshasa, the Democratic Republic of the Congo (DRC). Between April and July 2004, antenatal attendees at two of the largest maternity clinics in Kinshasa were tested to identify HIV status, syphilis, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). HIV seroprevalence was 1·9% in 2082 women. With PCR techniques, CT and NG infections were also uncommon in the first 529 women (1·7% and 0·4%, respectively). No active syphilis infection case was identified by Treponema pallidum haemagglutination assay (TPHA) and rapid plasma reagin test (RPR). A woman's risk of HIV infection was significantly associated with her reporting a male partner having had other female sexual partners (OR 2·7, 95% CI 1·2–6·2). The continuing low seroprevalence of HIV in pregnant women from Kinshasa was confirmed. Understanding factors associated with this phenomenon could help prevent a future HIV epidemic in low HIV transmission areas in Africa.
Aspects of the Bosonic Spectral Action
Creators: name: Sakellariadou, Mairi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A brief description of the elements of noncommutative spectral geometry as an approach to unification is presented. The physical implications of the doubling of the algebra are discussed. Some high energy phenomenological as well as various cosmological consequences are presented. A constraint in one of the three free parameters, namely the one related to the coupling constants at unification, is obtained, and the possible role of scalar fields is highlighted. A novel spectral action approach based upon zeta function regularisation, in order to address some of the issues of the traditional bosonic spectral action based on a cutoff function and a cutoff scale, is discussed.
description: 16 pages, Invited talk in the Fourth Symposium on Prospects in the Physics of Discrete Symmetries, DISCRETE 2014, King's College London,2-6 December 2014
Mapping evolutionary process: a multi-taxa approach to conservation prioritization
Creators: name: Fuller, Trevon
name: Schlunegger, Jasmin
name: Saatchi, Sassan
name: Wang, Ophelia
name: Cameron, Susan E
name: Jarrín-V, Pablo
name: Smith, Thomas B
name: Buermann, Wolfgang
name: Thomassen, Henri A
name: Kieswetter, Charles M
name: Schneider, Christopher J
name: Peralvo, Manuel
name: Graham, Catherine H
name: Milá, Borja
name: Wayne, Robert K
name: Chan, Janice
name: Pollinger, John P
name: Schweizer, Rena
name: Mason, Eliza
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Human-induced land use changes are causing extensive habitat fragmentation. As a result, many species are not able to shift their ranges in response to climate change and will likely need to adapt in situ to changing climate conditions. Consequently, a prudent strategy to maintain the ability of populations to adapt is to focus conservation efforts on areas where levels of intraspecific variation are high. By doing so, the potential for an evolutionary response to environmental change is maximized. Here, we use modeling approaches in conjunction with environmental variables to model species distributions and patterns of genetic and morphological variation in seven Ecuadorian amphibian, bird, and mammal species. We then used reserve selection software to prioritize areas for conservation based on intraspecific variation or species-level diversity. Reserves selected using species richness and complementarity showed little overlap with those based on genetic and morphological variation. Priority areas for intraspecific variation were mainly located along the slopes of the Andes and were largely concordant among species, but were not well represented in existing reserves. Our results imply that in order to maximize representation of intraspecific variation in reserves, genetic and morphological variation should be included in conservation prioritization.
(192) James Rankin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Asymptotic freedom in the front-form Hamiltonian for quantum chromodynamics of gluons
Creators: name: Gomez-Rocha, Maria
name: Glazek, Stanislaw D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Asymptotic freedom of gluons in QCD is obtained in the leading terms of their renormalized Hamiltonian in the Fock space, instead of considering virtual Green's functions or scattering amplitudes. Namely, we calculate the three-gluon interaction term in the front-form Hamiltonian for effective gluons in the Minkowski space-time using the renormalization group procedure for effective particles (RGPEP), with a new generator. The resulting three-gluon vertex is a function of the scale parameter, $s$, that has an interpretation of the size of effective gluons. The corresponding Hamiltonian running coupling constant, $g_λ$, depending on the associated momentum scale $λ= 1/s$, is calculated in the series expansion in powers of $g_0 = g_{λ_0}$ up to the terms of third order, assuming some small value for $g_0$ at some large $λ_0$. The result exhibits the same finite sensitivity to small-$x$ regularization as the one obtained in an earlier RGPEP calculation, but the new calculation is simpler than the earlier one because of a simpler generator. This result establishes a degree of universality for pure-gauge QCD in the RGPEP.
description: 23 pages, 8 figures
Systems biology and proteomic analysis of cerebral cavernous malformation
Creators: name: Saldarriaga, Ivandario
name: Edelmann, Alexander
name: Carlson, Jim
name: Bencharit, Sompop
name: Schwartz-Baxter, Sarah
name: Dibble, Christopher
name: Byrd, Warren
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cerebral cavernous malformations (CCM) are vascular anomalies caused by mutations in genes encoding KRIT1, OSM and PDCD10 proteins causing hemorrhagic stroke. We examine proteomic change of loss of CCM gene expression. Using human umbilical vein endothelial cells, label-free differential protein expression analysis with multidimensional liquid chromatography/tandem mass spectrometry was applied to three CCM protein knockdown cell lines and two control cell lines: ProteomeXchange identifier PXD000362. Principle component and cluster analyses were used to examine the differentially expressed proteins associated with CCM. The results from the five cell lines revealed 290 and 192 differentially expressed proteins (p < 0.005 and p < 0.001, respectively). Most commonly affected proteins were cytoskeleton-associated proteins, in particular myosin-9. Canonical genetic pathway analysis suggests that CCM may be a result of defective cell–cell interaction through dysregulation of cytoskeletal associated proteins.
Effects of 3D Geometries on Cellular Gradient Sensing and Polarization
Creators: name: Spill, Fabian
name: Andasari, Vivi
name: Mak, Michael
name: Kamm, Roger D.
name: Zaman, Muhammad H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Subcellular Processes (q-bio.SC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is determined by intracellular signaling networks. It results in directional forces through actin polymerization and myosin contractions. Many existing mathematical models of cell polarization are formulated in terms of reaction-diffusion systems of interacting molecules, and are often defined in one or two spatial dimensions. In this paper, we introduce a 3D reaction-diffusion model of interacting molecules in a single cell, and find that cell geometry has an important role affecting the capability of a cell to polarize, or change polarization when an external signal changes direction. Our results suggest a geometrical argument why more roundish cells can repolarize more effectively than cells which are elongated along the direction of the original stimulus, and thus enable roundish cells to turn faster, as has been observed in experiments. On the other hand, elongated cells preferentially polarize along their main axis even when a gradient stimulus appears from another direction. Furthermore, our 3D model can accurately capture the effect of binding and unbinding of important regulators of cell polarization to and from the cell membrane. This spatial separation of membrane and cytosol, not possible to capture in 1D or 2D models, leads to marked differences of our model from comparable lower-dimensional models.
description: 31 pages, 7 figures
title: De l'arbre à la forêt : singularité et généralisation dans les modèles physiques
Creators: name: CHAMPION, Isabelle
Publisher: name: Journal of Interdisciplinary Methodologies and Issues in Science - JIMIS-CNRS-Episciences-ESPACE-Agorantic
Year: 2017
Subjects: subject: Représentation
subject: Forêt
subject: Arbre
subject: Architecture
subject: Modélisation
subject: Télédétection
subject: Échantillonnage

description: Dans tout problème de science et en particulier ceux qui impliquent une modélisation de phénomènes physiques à l'aide d'un ensemble d'équations mathématiques, la question de passer du singulier au général est centrale. L'exemple développé ici est celui de la modélisation du signal électromagnétique d'une forêt afin d’exploiter des images satellitaires pour diverses applications. Pour interpréter le signal reçu, le physicien 15 utilise donc un modèle mathématique qui résume le savoir en cours sur la formation du signal en fonction des caractéristiques de la forêt. La discipline produit énormément de travaux de modélisation qui utilisent des données sur les arbres et les  descriptions  de  l'arbre  sont  souvent  traitées  comme  secondaires  par  rapport  à  la  construction  de l'appareil  mathématique.  Or,  la  description  de  l'arbre  qui  va  produire  le  fichier  d'entrée  du  modèle  est fondamentale  pour  le  calcul  du  résultat.  Il  semble  que  cette  description  est  traitée  comme  une  non-question de recherche peut-être parce que c'est un objet naturel et non une création de la technologie, ou parce  qu'il  s'agit  d'un  objet  mesurable  par  des  moyens  simples, qu'il  est  immédiatement  accessible (contrairement à la description de l'ADN par exemple). Bref, un  arbre : ça crève les yeux...  Or, nous montrons ici que l'arbre du physicien est une création 25 totalement nouvelle et originale et que c'est le résultat d’un travail complexe d'élaboration au même titre que l'établissement des équations qui composent le modèle mathématique.
Objective Measures in Aesthetic and Functional Nasal Surgery: Perspectives on Nasal Form and Function
Creators: name: Rhee, John
name: Pawar, Sachin
name: Kimbell, Julia
name: Garcia, Guilherme
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The outcomes of aesthetic and functional nasal surgery are difficult to assess objectively due to the intricate balance between nasal form and function. Despite historical emphasis on patient-reported subjective measures, objective measures are gaining importance in both research and the current outcomes-driven healthcare environment. Objective measures presently available have several shortcomings which limit their routine clinical use. In particular, the low correlation between objective and subjective measures poses a major challenge. However, advances in computer, imaging, and bioengineering technology are now setting the stage for the development of innovative objective assessment tools for nasal surgery that can potentially address some of the current limitations. Assessment of nasal form following aesthetic surgery is evolving from two-dimensional analysis to more sophisticated three-dimensional analysis. Similarly, assessment of nasal function is evolving with the introduction of computational fluid dynamics techniques, which allow for a detailed description of the biophysics of nasal airflow. In this paper, we present an overview of objective measures in both aesthetic and functional nasal surgery and discuss future trends and applications that have the potential to change the way we assess nasal form and function.
An assessment of the correlation-based particle identification (CPI) method in the framework of Dual-Plane Stereo-Astigmatism (DPSA)
Creators: name: Kling, Nils H.
name: Kriegseis, Jochen
name: Haller, Florian
name: Opfer, Lars
name: Rogler, Philipp
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2019

description: A synthetic study is conducted to assess the performance of the correlation-based particle identification method (CPI). As a technique developed in the context of Dual-Plane StereoAstigmatism (DPSA), the CPI method allows the identification of particle image shapes by utilizing image cross-correlation. The performance assessment addresses the influence of noise, particle density, particle image size and particle image deformation. The study shows viable results for low to moderate particle densities. Generally, a stronger performance of the CPI method is observed for small particle image sizes and pronounced particle image deformations. However, in the absence of particle overlapping, such as in the case of small particle densities, bigger particle images show a stronger performance, since a finer numerical discretization of the particle image provides a more accurate computation of the image cross-correlation. A stronger incorporation of particle overlapping increases the rate of particle identification, however it diminishes the accuracy of particle localization and particle allocation.
Imperfect spreading on temporal networks
Creators: name: Gueuning, Martin
name: Delvenne, Jean-Charles
name: Lambiotte, Renaud
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We study spreading on networks where the contact dynamics between the nodes is governed by a random process and where the inter-contact time distribution may differ from the exponential. We consider a process of imperfect spreading, where transmission is successful with a determined probability at each contact. We first derive an expression for the inter-success time distribution, determining the speed of the propagation, and then focus on a problem related to epidemic spreading, by estimating the epidemic threshold in a system where nodes remain infectious during a finite, random period of time. Finally, we discuss the implications of our work to design an efficient strategy to enhance spreading on temporal networks.
description: 5 pages
In vivo γ-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects
Creators: name: Wu, Weidong
name: Robinette, Carole
name: Peden, David
name: Jiang, Qing
name: Wiser, Jessica
name: Alexis, Neil
name: Roubey, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We have recently reported that gamma tocopherol (γT) reduces allergen and zymosan-induced inflammation using rodent models. As an initial step in extending these observations to humans, we conducted an open-label, Phase I dosing study of two doses (one or two capsules/daily for one week) of a gamma tocopherol rich preparation containing 623mg of γ tocopherol, 61.1mg of d-α-tocopherol, 11.1 mg of d-β-tocopherol (11.1mg), and 231 mg of d-σ-tocopherol per capsule. Endpoints for this study include serum levels of 5-nitro-gamma tocopherol, as a marker of oxidative stress, and changes in serum gamma, alpha and delta tocopherol and γ-2′-carboxyethyl-6-hydroxychroman (CEHC) six and 24 hours after the first dose and after 1 week of treatment. To assess biological activity of this treatment, we obtained peripheral blood mononuclear cells at baseline and after 1 week of treatment with 2 capsules of a gamma tocopherol rich preparation/day, and examined the inflammatory cytokine response of these cells in culture to ex-vivo endotoxin/LPS (0.01 ng/ml) challenge. We also monitored a number of safety endpoints to examine how well this preparation is tolerated in 8 normal volunteers (4 allergic and 4 non-allergic) and 8 allergic asthmatics. We further obtained human monocytes from a subset of these volunteers and treated them ex vivo with γT, αT,γ-CEHC and α-CEHC and assessed their actions on LPS induced degradation of IkBα, and JNK signaling and ROS generation. As detailed herein, this open label study demonstrates that gamma tocopherol enriched supplementation decreased systemic oxidative stress, increased serum levels of gamma tocopherol, and inhibited monocyte responses to LPS without any adverse health effects. Further,in vitro treatment of human monocytes with γ-CEHC and α-CEHC inhibits ROS generation and LPS-induced degradation of IκB and JNK activation.
(194) James Paterson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Συγκριτική μελέτη σκοπιμότητας εγκατάστασης ανεμογεννήτριας στο Πολυτεχνείο Κρήτης
title: Comparative study for the purpose of installing wind turbine in the Technical University of Crete
Creators: name: Καλαϊτζακης Μανωλης
Publisher: name: Technical University of Crete
Year: 2020

description: Σκοπός της εργασίας αυτής είναι η εύρεση της διαδικασίας απόφασης και επιλογής εγκατάστασης μιας ανεμογεννήτριας από μία δειγματική λίστα κάποιων μοντέλων ανεμογεννητριών διαθέσιμων στην αγορά.
            Θα χρησιμοποιηθούν ανεμολογικά δεδομένα της περιοχής, ώστε μέσω ενός αλγορίθμου στην Matlab, να γίνει η προσομοίωση της ετήσιας παραγωγής ηλεκτρισμού των ανεμογεννητριών ώστε να ξεκινήσει η σύγκριση.
            Τέλος, θα συνυπολογιστούν οικονομικά κριτήρια, όπως τα κόστη εγκατάστασης και συντήρησης, και ο χρόνο απόσβεσης της επένδυσής, για να γίνει η τελική επιλογή του μοντέλου της ανεμογεννήτριας και να αποφανθούν συμπεράσματα για τον σκοπό και το αποτέλεσμα της μελέτης αυτής.
Long-chain acyl-CoA synthetases and fatty acid channeling
Creators: name: Coleman, Rosalind
name: Li, Lei
name: Mashek, Douglas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Thirteen homologous proteins comprise the long-chain acyl-CoA synthetase (ACSL), fatty acid transport protein (FATP), and bubblegum (ACSBG) subfamilies that activate long-chain and very-long-chain fatty acids to form acyl-CoAs. Gain- and loss-of-function studies show marked differences in the ability of these enzymes to channel fatty acids into different pathways of complex lipid synthesis. Further, the ability of the ACSLs and FATPs to enhance cellular FA uptake does not always require these proteins to be present on the plasma membrane; instead, FA uptake can be increased by enhancing its conversion to acyl-CoA and its metabolism in downstream pathways. Since altered fatty acid metabolism is a hallmark of numerous metabolic diseases and pathological conditions, the ACSL, FATP and ACSBG isoforms are likely to play important roles in disease etiology.
Scalarized Hairy Black Holes
Creators: name: Kleihaus, Burkhard
name: Kunz, Jutta
name: Yazadjiev, Stoytcho
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the presence of a complex scalar field scalar-tensor theory allows for scalarized rotating hairy black holes. We exhibit the domain of existence for these scalarized black holes, which is bounded by scalarized rotating boson stars and ordinary hairy black holes. We discuss the global properties of these solutions. Like their counterparts in general relativity, their angular momentum may exceed the Kerr bound, and their ergosurfaces may consist of a sphere and a ring, i.e., form an ergo-Saturn.
description: 11 pages, 4 figures
Epistatic interactions of genes influence within-individual variation of physical activity traits in mice
Creators: name: Lightfoot, J. Timothy
name: Leamy, Larry
name: Pomp, Daniel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A number of quantitative trait loci (QTLs) recently have been discovered that affect various activity traits in mice, but their collective impact does not appear to explain the consistently moderate to high heritabilities for these traits. We previously suggested interactions of genes, or epistasis, might account for additional genetic variability of activity, and tested this for the average distance, duration and speed run by mice during a 3 week period. We found abundant evidence for epistasis affecting these traits, although, recognized that epistatic effects may well vary within individuals over time. We therefore conducted a full genome scan for epistatic interactions affecting these traits in each of seven three-day intervals. Our intent was to assess the extent and trends in epistasis affecting these traits in each of the intervals. We discovered a number of epistatic interactions of QTLs that influenced the activity traits in the mice, the majority of which were not previously found and appeared to affect the activity traits (especially distance and speed) primarily in the early or in the late age intervals. The overall impact of epistasis was considerable, its contribution to the total phenotypic variance varying from an average of 22–35% in the three traits across all age intervals. It was concluded that epistasis is more important than single-locus effects of genes on activity traits at specific ages and it is therefore an essential component of the genetic architecture of physical activity.
The equivalence principle and the relative velocity of local inertial frames
Creators: name: Shojai, F.
name: Shojai, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we explicitly show that in general relativity, the relative velocity of two local inertial frames is always less than the velocity of light. This fact is a by-product of the equivalence principle. The general result is then illustrated within two examples, the FLRW cosmological model and the Schwarzschild metric.
description: 1 Figure
Insights into DNA-mediated interparticle interactions from a coarse-grained model
Creators: name: Ding, Yajun
name: Mittal, Jeetain
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: DNA-functionalized particles have great potential for the design of complex self-assembled materials. The major hurdle in realizing crystal structures from DNA-functionalized particles is expected to be kinetic barriers that trap the system in metastable amorphous states. Therefore, it is vital to explore the molecular details of particle assembly processes in order to understand the underlying mechanisms. Molecular simulations based on coarse-grained models can provide a convenient route to explore these details. Most of the currently available coarse-grained models of DNA-functionalized particles ignore key chemical and structural details of DNA behavior. These models therefore are limited in scope for studying experimental phenomena. In this paper, we present a new coarse-grained model of DNA-functionalized particles which incorporates some of the desired features of DNA behavior. The coarse-grained DNA model used here provides explicit DNA representation (at the nucleotide level) and complementary interactions between Watson-Crick base pairs, which lead to the formation of single-stranded hairpin and double-stranded DNA. Aggregation between multiple complementary strands is also prevented in our model. We study interactions between two DNA- functionalized particles as a function of DNA grafting density, lengths of the hybridizing and non-hybridizing parts of DNA, and temperature. The calculated free energies as a function of pair distance between particles qualitatively resemble experimental measurements of DNA-mediated pair interactions.
description: 11 pages, 9 figures
Consistency of Scalar Potentials from Quantum de Sitter Space
Creators: name: Espinosa, José R.
name: Fortin, Jean-François
name: Trépanier, Maxime
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Consistency of the unconventional view of de Sitter space as a quantum theory of gravity with a finite number of degrees of freedom requires that Coleman-De Luccia tunneling rates to vacua with negative cosmological constant should be interpreted as recurrences to low-entropy states. This demand translates into two constraints, or consistency conditions, on the scalar potential which are generically: 1) the distance in field space between the de Sitter vacuum and any other vacuum with negative cosmological constant must be of the order of the reduced Planck mass or larger and 2) the fourth root of the vacuum energy density of the de Sitter vacuum must be smaller than the fourth root of the typical scale of the scalar potential. These consistency conditions shed a different light on both outstanding hierarchy problems of the Standard Model of particle physics: the scale of electroweak symmetry breaking and the scale of the cosmological constant. Beyond the unconventional interpretation of quantum de Sitter space, we complete the analytic understanding of the thin-wall approximation of Coleman-De Luccia tunneling, extend its numerical analysis to generic potentials and discuss the role of gravity in stabilizing the Standard Model potential.
description: 1+34 pages, 9 figures, v3 with more precise wording in abstract and introduction
β2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway
Creators: name: Zhang, Dan
name: Hu, Xiaoming
name: Wilson, Belinda
name: Hong, Jau-Shyong
name: Wu, Hung-Ming
name: Qian, Li
name: Snyder, Amanda
name: Lu, Ru-Band
name: Li, Yachen
name: Flood, Patrick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Activation of the β2 adrenergic receptor (β2AR) on immune cells has been reported to possess anti-inflammatory properties, however, the pro-inflammatory properties of β2AR activation remain unclear. In this study, using rat primary mesencephalic neuron-glia cultures, we report that salmeterol, a long-acting β2AR agonist, selectively induces dopaminergic (DA) neurotoxicity through its ability to activate microglia. Salmeterol selectively increased the production of reactive oxygen species (ROS) by NADPH oxidase (PHOX), the superoxide-producing enzyme in microglia. A key role of PHOX in mediating salmeterol-induced neurotoxicity was demonstrated by the inhibition of DA neurotoxicity in cultures pretreated with diphenylene-iodonium (DPI), an inhibitor of PHOX activity. Mechanistic studies revealed the activation of microglia by salmeterol results in the selective phosphorylation of ERK, a signaling pathway required for the translocation of the PHOX cytosolic subunit p47phox to the cell membrane. Furthermore, we found ERK inhibition, but not protein kinase A (PKA) inhibition, significantly abolished salmeterol-induced superoxide production, p47phox translocation, and its ability to mediate neurotoxicity. Together, these findings indicate that β2AR activation induces microglial PHOX activation and DA neurotoxicity through an ERK-dependent/PKA-independent pathway.
(189) Mary Anne McCulloch
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Prediction in Projection
Creators: name: Garland, Joshua
name: Bradley, Elizabeth
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Prediction models that capture and use the structure of state-space dynamics can be very effective. In practice, however, one rarely has access to full information about that structure, and accurate reconstruction of the dynamics from scalar time-series data---e.g., via delay-coordinate embedding---can be a real challenge. In this paper, we show that forecast models that employ incomplete embeddings of the dynamics can produce surprisingly accurate predictions of the state of a dynamical system. In particular, we demonstrate the effectiveness of a simple near-neighbor forecast technique that works with a two-dimensional embedding. Even though correctness of the topology is not guaranteed for incomplete reconstructions like this, the dynamical structure that they capture allows for accurate predictions---in many cases, even more accurate than predictions generated using a full embedding. This could be very useful in the context of real-time forecasting, where the human effort required to produce a correct delay-coordinate embedding is prohibitive.
description: 13 pages, 7 figures, 3 tables
Psychotherapeutic and psychosocial interventions with unaccompanied minors: A scoping review
Creators: name: Georgaca, Eugenie
name: Moutsou, Irene
name: Varaklis, Theofilos
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Clinical Psychology
subject: Psychology
subject: FOS: Psychology
subject: psychosocial support
subject: unaccompanied minors
subject: migrants
subject: mental health
subject: psychotherapy
subject: refugees

description: This is a scoping review of studies on psychotherapeutic and psychosocial interventions with unaccompanied minors. Their findings, methodological limitations and implications for future research are discussed.
Association Between Domestic Violence and HIV Serostatus Among Married and Formerly Married Women in Kenya
Creators: name: Onsomu, Elijah
name: Abuya, Benta
name: Okech, Irene
name: Duren-Winfield, Vanessa
name: Simmons, Amber
name: Rosen, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The prevalence of both domestic violence (DV) and HIV among Kenyan women is known to be high, but the relationship between them is unknown. Nationally representative cross-sectional data from married and formerly married (MFM) women responding to the Kenya Demographic and Health Survey 2008/2009 were analyzed adjusting for complex survey design. Multivariable logistic regressions were used to assess the covariate-adjusted associations between HIV serostatus and any reported DV as well as four constituent DV measures: physical, emotional, sexual, and aggravated bodily harm, adjusting for co-variates entered into each model using a forward stepwise selection process. Co-variates of a priori interest included those representing marriage history, risky sexual behavior, substance use, perceived HIV risk, and socio-demographic characteristics. The prevalence of HIV among MFM women was 10.7% (any DV: 13.1%, no DV: 8.6%); overall prevalence of DV was 43.4%. Among all DV measures, only physical DV was associated with HIV (11.9%; adjusted odds ratio: 2.01, p < 0.05). Efforts by the government and women's groups to monitor and improve policies to reduce DV, such as the Sexual Offences Act of 2006, are urgently needed to curb HIV, as are policies that seek to provide DV counseling and treatment to MFM women.
Primary health care in rural areas: an agenda for research.
Creators: name: Ricketts, T.C.
name: DeFriese, G.H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1989

description: In her discussion of the applicability of the primary care concept to the American health care system, Barbara Starfield (1986) points out that the framework for a 'primary' level of care - as promulgated in the United Kingdom since the Dawson Report of 1920 - simply does not exist in this country. Starfield argues that the classical use of the term 'primary care' has little meaning in the United Staes, where 'health services are not organized along geographic lines, physicians usually do not assume responsibility for defined populations, and there is no system in which health services are planned so that they are distributed according to local needs' (p. 184). Yet the notion of first-contact care, through which all subsequently necessary health care may be accessed and through which multiple sources and levels of care may be coordinated over time, remains a central idea in all of our efforts to assure the highest standards of health care for all Americans. The concept of primary care remains an important element of American health care planning, organization, and financing despite our long history of increasing specialization in medical practice and our preferential recognition of the specialty services in policies affecting physician payment.
Bootstrapping 3D Fermions
Creators: name: Iliesiu, Luca
name: Kos, Filip
name: Poland, David
name: Pufu, Silviu S.
name: Simmons-Duffin, David
name: Yacoby, Ran
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We study the conformal bootstrap for a 4-point function of fermions $\langleψψψψ\rangle$ in 3D. We first introduce an embedding formalism for 3D spinors and compute the conformal blocks appearing in fermion 4-point functions. Using these results, we find general bounds on the dimensions of operators appearing in the $ψ\times ψ$ OPE, and also on the central charge $C_T$. We observe features in our bounds that coincide with scaling dimensions in the Gross-Neveu models at large $N$. We also speculate that other features could coincide with a fermionic CFT containing no relevant scalar operators.
description: 45 pages, 8 figures; V2: added references and small clarifications to match JHEP version