cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chemically synthesised flavone and coumarin based isoxazole derivatives as broad spectrum inhibitors of serine β-lactamases and metallo-β-lactamases: a computational, biophysical and biochemical study
Creators: name: Farhat, Nabeela
name: Ali, Abid
name: Waheed, Mohd
name: Gupta, Divya
name: Khan, Asad U.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified

description: The β-lactam antibiotics are the most effective medicines for treating bacterial infections. Resistance to them, particularly through the production of β-lactamases, which can hydrolyse all kinds of β-lactams, poses a threat to their continued use. The synthesised flavone and coumarin based isoxazole derivatives have the potential to be used as broad-spectrum inhibitors of the mechanistically different serine-(SBL) and metallo-β-lactamases (MBL). The synthesised compounds were discovered as potent β-lactamase inhibitors using molecular docking and in silico pharmacokinetic analysis. We studied the binding of chemically synthesised inhibitors to clinically significant β-lactamases of class A, B, and C using biophysical and biochemical approaches, and computational analyses. These molecules follow Lipinski’s rule of five and have acceptable solubility, permeability, and oral bioavailability. These molecules were found to be non-toxic and non-carcinogenic. MIC results suggest that these molecules restore the antibiotic efficacy against class A, B, and C β-lactamases. Kinetics data showed that these molecules reduce the catalytic efficiency of clinically relevant class A, B, and C β-lactamases. Fluorescence study showed significant interaction between these flavone-/coumarin-based isoxazole derivatives and class A/B/ C β-lactamases. This study showed promising effect of these new generation compounds as broad spectrum β-lactamase inhibitors of both SBLs and MBLs. Communicated by Ramaswamy H. Sarma
Amtliche Mitteilungen der Universität Dortmund Nr. 01/87
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Dortmund
Year: 1987
Subjects: subject: 080

description: Fachbereichsrahmenordnung der Universität Dortmund vom 16. 12. 1986
description: Amtliche Mitteilungen der Universität Dortmund ; 1, 1987
Orbits of antichains in certain root posets
Creators: name: Dong, Chao-Ping
name: Wang, Suijie
Publisher: name: arXiv
Year: 2016
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 06A07

description: This paper gives another proof of Propp and Roby's theorem saying that the average antichain size in any reverse operator orbit of the poset $[m]\times [n]$ is $\frac{mn}{m+n}$. It is conceivable that our method should work for other situations. As a demonstration, we show that the average size of antichains in any reverse operator orbit of $[m]\times K_{n-1}$ equals $\frac{2mn}{m+2n-1}$. Here $K_{n-1}$ is the minuscule poset $[n-1]\oplus ([1] \sqcup [1]) \oplus [n-1]$. Note that $[m]\times [n]$ and $[m]\times K_{n-1}$ can be interpreted as sub-families of certain root posets. We guess these root posets should provide a unified setting to exhibit the homomesy phenomenon defined by Propp and Roby.
description: 17 pages, type D handled
(200779) William Langley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Designing ferritin nanocage based vaccine candidates for SARS-CoV-2 by in silico engineering of its HLA I and HLA II epitope peptides
Creators: name: Manickavasagam, Pratibha
name: Abhishek, Suman
name: Rajakumara, Eerappa
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Cancer
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: New variants of SARS-CoV-2 are continuously being reported. To curtail the spread of this virus, it is essential to find an efficient and potent vaccine. Here, we report in silico designing of a protein (ferritin: FR) nanocage fused with multiple epitopes identified using the immuno-informatics approach and high-throughput screening. Employing computational approaches, we identified potential epitopes from membrane, nucleocapsid, and envelope proteins of SARS-CoV-2 and docked them on the selected human leukocyte antigen Class I and II receptors, then the stability of the complexes was assessed using molecular dynamics simulation studies. We have engineered chimeric ferritin nanocage, chm66FR, with the nested peptide of 10 epitopes by replacing the loop region at the 66th position of the nanocage, then its stability was confirmed using metadynamics simulation. Further, we used the homotrimeric ‘6-helical bundle’ of the spike protein to engineer the chimeric 6HB (chm6HB). The chm6HB is, engineered with three epitope peptides, mounted on the N-terminal trimeric interface of the chm66FR to generate the chm6HB-chm66FR, which contains 15 epitope peptides. Chimeric FR nanocages and the chm6HB could be potential vaccine candidates against strains of SARS-CoV-2. These multivalent and multiple epitopes protein nanocages and scaffolds could mount both humoral and T-cell mediated immune responses against SARS-CoV-2. Communicated by Ramaswamy H. Sarma
Observations of gravity-capillary lump interactions
Creators: name: Masnadi, Naeem
name: Duncan, James H.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: In this experimental study, we investigate the interaction of gravity-capillary solitary waves generated by two surface pressure sources moving side by side at constant speed. The nonlinear response of a water surface to a single source moving at a speed just below the minimum phase speed of linear gravity-capillary waves in deep water ($c_{min}\approx23$ cm s$^{-1}$) consists of periodic generation of pairs of three-dimensional solitary waves (or lumps) in a V-shaped pattern downstream of the source. In the reference frame of the laboratory, these unsteady lumps propagate in a direction oblique to the motion of the source. In the present experiments, the strengths of the two sources are adjusted to produce nearly identical responses and the free-surface deformations are visualized using photography-based techniques. The first lumps generated by the two sources move in intersecting directions that make a half angle of approximately 15 degrees and collide in the centerplane between the sources. A steep depression is formed during the collision, but this depression quickly decreases in amplitude while radiating small-amplitude radial waves. After the collision, a quasi-stable pattern is formed with several rows of localized depressions that are qualitatively similar to lumps but exhibit periodic amplitude oscillations, similar to a breather. The shape of the wave pattern and the period of oscillations depend strongly on the distance between the sources.
description: 11 pages, 10 figures
Flap sub-domain dynamics of serine-threonine phosphatase (Stp1) of Staphylococcus aureus: an accelerated molecular dynamics simulation study
Creators: name: Mandal, Pranabesh
name: Rani, Priyanka
name: Chandra, Girish
name: Singh, Durg Vijay
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Vancomycin and daptomycin are commonly used glycopeptide antibiotics to cure Gram-positive staphylococcal infections. The clinical isolates of mutant Staphylococcus aureus strains, Methicillin-Resistant (MRSA) and Vancomycin-Resistant (VRSA), have developed resistance against these antibiotics. A recently discovered Serine/threonine phosphatase (Stp1) is an Mn+2 containing protein at the active site with a flap sub-domain that participates in the phospho-signaling system of bacterial cell wall formation. The flap sub-domain probably regulates substrates recruitment and release with an extra Mn+2, possibly highly flexible as in the other homologous family of proteins. In this study, the flap sub-domain has been sampled with conventional and accelerated molecular dynamics (cMD and aMD) simulations to get other sub-optimal conformational states of the protein that are nearly impossible to observe through experimental methods. Trajectory analysis has shown that protein remained static in cMD while dynamic in aMD with RMSD of ∼2Å and ∼3Å, respectively. Accelerated MD has shown greater flexibility of ∼4 Å in the flap sub-domain, while cMD only captured a deviation of ∼ 2 Å. Later, the dynamic cross-correlation map (DCCM) confirmed that the flap sub-domain is significantly more flexible than the other part of the structure, indicating its role in substrate regulation. Secondary structure transition in the flap sub-domain, i.e. 3-10 helix and turn (PRO159 - ILE163) region of the flap sub-domain shifted into α-helix, which is a more stable structure. Further, the trajectory has been clustered, and conformational states extracted, which may be exploited in structure-based antibiotics discovery. Communicated by Ramaswamy H. Sarma
(200775) Thomas Harrison
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Amtliche Mitteilungen der Universität Dortmund Nr. 79
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Dortmund
Year: 1977
Subjects: subject: 080

description: Vorläufige Diplomprüfungsordnung für die Diplomprüfung im Fach Informatik
description: Vorläufige Studienordnung der Abteilung Informatik
description: Amtliche Mitteilungen der Universität Dortmund ; 79
Enhanced Blind Maximum Ratio Combining in Broadcasting Systems
Creators: name: Ahmed, Rana
name: Eitel, Ben
name: Speidel, Joachim
Publisher: name: Technische Universität Dortmund
Year: 2013
Subjects: subject: 620

description: We propose an enhanced blind maximum ratio combiner (BMRC) allowing for a transmit signal independent diversity combining in multi-antenna receivers. The underlying Multi-Channel Frequency Least Mean Squares (MCFLMS) algorithm comes with reasonable computational complexity and estimates the channel impulse response for each receive antenna iteratively by means of second order statistics. In literature, the MCFLMS algorithm is mainly applied to audio signals. In this work, we describe several enhancements of this algorithm to ensure its proper convergence with oversampled communication signals which are distorted by frequency-selective fast-fading channels. In addition, we provide BER simulation results for a 1x2 SIMO DVB-T2 system and show that our blind MRC can even outperform conventional pilot-based MRC at the receiver side.
Amtliche Mitteilungen der Universität Dortmund Nr. 03/85
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Dortmund
Year: 1985
Subjects: subject: 080

description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Biologie (Fachbereich Erziehungswissenschaften und Biologie)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Englische Sprache und Literatur (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Geschichte (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Musik (Fachbereich Musik, Gestaltung, Sport und Geographie)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Politikwissenschaft (Fachbereich Gesellschaftswissenschaften, Philosophie und Theologie)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Psychologie (Fachbereich Gesellschaftswissenschaften, Philosophie und Theologie)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Raumplanung
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Soziologie (Fachbereich Gesellschaftswissenschaften, Philosophie und Theologie)
description: Zweitfachvereinbarungen des Faches Journalistik (Fachbereich Sprach- und Literaturwissenschaften, Journalistik und Geschichte) über die Zweitfächer im Diplomstudiengang Journalistik: Spezielle Volkswirtschaftslehre - Wirtschaftspolitik - (Fachbereich Wirtschafts- und Sozialwissenschaften)
description: Amtliche Mitteilungen der Universität Dortmund ; 3, 1985
(200776) John Cressy Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mean Coronary Cross‐Sectional Area as a Measure of Arterial Remodeling Using Noncontrast CT Imaging in Persons With HIV
Creators: name: Werede, Ayoda
name: Terry, James
name: Nair, Sangeeta
name: Temu, Tecla M.
name: E Shepherd, Bryan
name: Bailin, Samuel
name: Mashayekhi, Mona
name: Gabriel, Curtis L.
name: Lima, Morgan
name: Woodward, Beverly O.
name: Hannah, LaToya
name: Mallal, Simon A.
name: Beckman, Joshua A
name: Li, Jonathan Z.
name: Fajnzylber, Jesse
name: G. Harrison, David
name: Carr, John Jeffrey
name: Koethe, John R.
name: Wanjalla, Celestine N.
Publisher: name: Health Research Alliance
Year: 2023
Subjects: Infectious agents
Virology

description: Manuscript
Binding energy analysis and molecular dynamic simulation studies of the designed orally active, non-toxic GABARAP modulators
Creators: name: Nambiar, Megha P.
name: Ashwanikumar, N.
name: Anoop, Anakuthil
name: Biju, A. R.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified

description: Epilepsy is a severe neurological disorder that occurs when the communication between the neurons is disturbed. Gamma-amino butyric acid-associated protein (GABARAP) plays a key role in balancing Gamma-aminobutyric acid-A (GABA(A)) receptor functions of inhibiting the neurotransmission and controlling the seizure. In this study, we introduce the derivatives of the selected anti-epileptic drugs, namely Felbamate and Clobazam, by substituting different hydrophilic and hydrophobic groups at the specified positions. Molecular docking studies between the derivatives and GABARAP were carried out using PyRx software. The interacting residues were identified from LigPlot+. Drug-likeness, drug-related properties, and toxic endpoints of each derivative were analyzed using the SwissADME, Osiris property explorer, and ProTox-II servers. After analyzing the binding energy, drug-properties, and toxicity, the best five derivatives of Felbamate and Clobazam were selected. Molecular Dynamic simulation studies involving the target-ligand interaction were carried out for 100 nanoseconds using GROMACS 2018. The root mean square deviation, root mean square fluctuation, radius of gyration, Solvent accessible area, Energy plots and trajectories of the ten GABARAP complexes of the derivatives, and two GABARAP complexes of parent drugs were compared and critically analyzed. Among the five Felbamate derivatives, F7 formed the most stable complex with GABARAP. Among the five Clobazam derivatives, C27, C33 and C32 showed stable GABARAP interaction. In light of the above systematic computational analysis, we propose F7, C27, C33, and C32 as the potential anti-epileptic drug candidates for developing novel therapeutics. The substitution of hydrophobic groups at para position on benzene ring has promoted strong binding to GABARAP. Communicated by Ramaswamy H. Sarma
Evolution of the Cyber Security Threat: An Overview of the Scale of Cyber Threat
Creators: name: Fadziso, Takudzwa
name: Rao Thaduri, Upendar
name: Dekkati, Sreekanth
name: Ballamudi, Venkata Koteswara Rao
name: Desamsetti, Harshith
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 460499
subject: Cybersecurity and privacy not elsewhere classified
classificationCode: 460407
subject: System and network security
classificationCode: 460404
subject: Digital forensics
classificationCode: 460403
subject: Data security and protection

description: It is impossible to dismiss the importance of cybersecurity in today's digital world. Even a single breach in security can result in the exposure of the personal information of millions of individuals. Because of these breaches, the organizations suffer significant financial repercussions, and their customers lose trust. As a result, adequate cyber security is necessary to safeguard individuals and businesses from spammers and other cybercriminals. The term "cyber security" refers to the collection of technologies, procedures, and practices intended to protect networks, devices, programs, and data from being attacked, damaged, or accessed without authorization. Information technology security is another term that can be used interchangeably with cyber security. This study sheds light on some tactics, rapid measures, and forward-looking perspectives about cyber security and cyber danger.
$J/ψ$ Production in Polarized and Unpolarized $ep$ Collision and Sivers and $\cos2ϕ$ Asymmetries
Creators: name: Mukherjee, Asmita
name: Rajesh, Sangem
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the Sivers and $\cos2ϕ$ azimuthal asymmetries in $J/ψ$ production in polarized and unpolarized semi-inclusive $ep$ collision respectively, using the formalism based on transverse momentum dependent parton distributions (TMDs). Non-relativistic QCD based color octet model is employed for calculating the $J/ψ$ production rate. The Sivers asymmetry in this process directly probes the gluon Sivers function. The estimated Sivers asymmetry at $z=1$ is negative which is in good agreement with COMPASS data. We also investigate the effect of TMD evolution on the Sivers asymmetry. The $\cos2ϕ$ asymmetry is sizable and probes the linearly polarized gluon distribution in an unpolarized proton.
description: 29 pages, 11 figures. Details of calculation added
Equilibrium properties of blackbody radiation with an ultraviolet energy cut-off
Creators: name: Mishra, Dheeraj Kumar
name: Chandra, Nitin
name: Vaibhav, Vinay
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study various equilibrium thermodynamic properties of blackbody radiation (i.e. a photon gas) with an ultraviolet energy cut-off. We find that the energy density, specific heat etc. follow usual acoustic phonon dynamics as have been well studied by Debye. Other thermodynamic quantities like pressure, entropy etc. have also been calculated. The usual Stefan-Boltzmann law gets modified. We observe that the values of the thermodynamic quantities with the energy cut-off is lower than the corresponding values in the theory without any such scale. The phase-space measure is also expected to get modified for an exotic spacetime appearing at Planck scale, which in turn leads to the modification of Planck energy density distribution and the Wien's displacement law. We found that the non-perturbative nature of the thermodynamic quantities in the SR limit (for both the case with ultravilolet cut-off and the modified measure case), due to nonanalyticity of the leading term, is a general feature of the theory accompanied with an ultraviolet energy cut-off. We have also discussed the possible modification in the case of Big Bang and the Stellar objects and have suggested a table top experiment for verification in effective low energy case.
description: 26 pages, 9 figures; Published version; Some new calculations added
Parametric Presburger arithmetic: logic, combinatorics, and quasi-polynomial behavior
Creators: name: Bogart, Tristram
name: Goodrick, John
name: Woods, Kevin
Publisher: name: arXiv
Year: 2016
Subjects: subject: Combinatorics (math.CO)
subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 05A15, 52B20, 03C10

description: Parametric Presburger arithmetic concerns families of sets S_t in Z^d, for t in N, that are defined using addition, inequalities, constants in Z, Boolean operations, multiplication by t, and quantifiers on variables ranging over Z. That is, such families are defined using quantifiers and Boolean combinations of formulas of the form a(t) x <= b(t), where a(t) is in Z[t]^d, b(t) in Z[t]. A function g: N -> Z is a quasi-polynomial if there exists a period m and polynomials f_0, ..., f_{m-1} in Q[t] such that g(t)=f_i(t) for t congruent to i (mod m.) Recent results of Chen, Li, Sam; Calegari, Walker; Roune, Woods; and Shen concern specific families in parametric Presburger arithmetic that exhibit quasi-polynomial behavior. For example, S_t might be an a quasi-polynomial function of t or an element x(t) in S_t might be specifiable as a function with quasi-polynomial coordinates, for sufficiently large t. Woods conjectured that all parametric Presburger sets exhibit this quasi-polynomial behavior. Here, we prove this conjecture, using various tools from logic and combinatorics.
description: 34 pages, 1 figure. Minor changes, including to the title
(200773) Alfred Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Implementing accelerated dynamics to unravel the effects of high-fidelity Cas9 mutants on target DNA and guide RNA hybrid stability
Creators: name: Vora, Dhvani Sandip
name: Jaiswal, Atul Kumar
name: Sundar, Durai
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
classificationCode: 29999
subject: Physical Sciences not elsewhere classified
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 60506
subject: Virology

description: The clustered regularly interspersed short palindromic repeats (CRISPR) and its associated nuclease (Cas9) offers a unique and easily reprogrammable system for editing eukaryotic genomes. Cas9 is guided to the target by an RNA strand, and precise edits are created by introducing double-stranded breaks. However, nuclease activity of Cas9 is also triggered at other sites other than the target sit, which is a major limitation for various applications. Cas9 variants have been designed to improve the efficacy of the tool by introducing certain mutations. However, the on-target activity of such Cas9 variants is often seen as compromised. Hence, understanding the sub-molecular differences in the variants is essential to elucidate the factors that contribute to efficiency. The study reveals distortions in the PAM-distal regions of the nucleic hybrids as well as changes in the interactions between the Cas9 variants and RNA-DNA hybrid, contributing to the explanation for differences in on-target activity. Communicated by Ramaswamy H. Sarma
Additional file 1 of Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
Creators: name: Pascetta, Sydney A.
name: Kirsh, Sarah M.
name: Cameron, Makenna
name: Uniacke, James
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1
On the distribution of Rudin-Shapiro polynomials and lacunary walks on $SU(2)$
Creators: name: Rodgers, Brad
Publisher: name: arXiv
Year: 2016
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Number Theory (math.NT)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: We characterize the limiting distribution of Rudin-Shapiro polynomials, showing that, normalized, their values become uniformly distributed in the disc. This resolves conjectures of Saffari and Montgomery. Our proof proceeds by relating the polynomials' distribution to that of a product of weakly dependent random matrices, which we analyze using the representation theory of $SU(2)$. Our approach leads us to a non-commutative analogue of the classical central limit theorem of Salem and Zygmund, which may be of independent interest.
description: 14 pages. Incorporates referee suggestions
One-Dimensional Metallic Edge States in MoS2
Creators: name: Bollinger, M. V.
name: Helveg, S.
name: Jacobsen, K. W.
name: Lauritsen, J. V.
name: Nørskov, J. K.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
(200774) Philip Twells
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Eulichas birmanica Hajek, sp. nov.
Creators: name: Hájek, Ji Ř Í
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Eulichadidae
Eulichas
Eulichas birmanica

description: Eulichas birmanica Hájek, sp. nov.
(Figs. 27, 43, 65)
Type locality. Myanmar, Tenasserim, Pong Hang.
Type material. 5 specimens — Holotype ɗ (NMPC), labelled: “ MYANMAR (Burma) I.2001 / Tenasserim / PONG HANG / local collector leg. (viaG. Benzt) [printed] // Eulichadidae [handwritten] / det. C. Wurst 2003 [printed]”. Paratypes: 1 ɗ (no. 1), same label data as holotype (NMPC); 3 ɗɗ (nos. 2–4), “ BURMA / Tenasserim / 29.4.1995 / leg.S.Steinke [printed]” (NHMW, NMPC).
Description. Habitus elongate, fusiform. Body colouring brownish-red to brown-blackish. Pale part of setation consists of recumbent grey-yellowish setae forming typical ocellations on pronotum, elytra and abdominal sternites, where setae are darker and sparser (Fig. 65).
Measurements. Males: 16–19 mm (holotype 18 mm).
Head punctation consists of coarse setigerous punctures, larger and sparser on the frons, and smaller and denser on the vertex. Antenna relatively slender, last antennomere drop shaped, ca. 3.00–3.25 times as long as wide (Fig. 43). Its ventral side with setigerous punctures, tubercles almost imperceptible.
Pronotum largely transverse, ca. 2.10–2.16 times as wide as long. Sides almost regularly rounded. Disc convex. Punctation consists of fine setigerous punctures, distributed sparsely on the disc, and somewhat densely laterally.
Elytra with numerous longitudinal rows of large setigerous punctures, and very fine interstitial punctures.
Ventral part with fine punctures, which are sparse medially and become larger and denser laterally. Last abdominal ventrite laterally regularly rounded to apex.
Male. Aedeagus with phallobase longer than parameres. Parameres relatively long and slender, simple. Subapical parameral hook well developed. The subbasal parameral hook is reduced to an indistinct swelling. Median lobe narrowly lanceolate with subbasal lateral processes indistinct, its subbasal spines turned dorsolaterally (Fig. 27).
Female. Unknown.
Differential diagnosis. Eulichas birmanica sp. nov. is characterised by a relatively small body length, and last antennomere slender, drop shaped. Among the species of its species complex, E. birmanica sp. nov. is very similar to E. jaechi sp. nov., which it resembles in habitus, body length and colouration. These species can only be distinguished by the male genitalia. The median lobe of E. birmanica sp. nov. is narrowly lanceolate, without a distinct lateral processes.
Distribution. Known only from “Tenasserim”, southern Myanmar.
Etymology. The name is derived from “ Birmania ”, Latin name for Burma (currently Myanmar).
description: Published as part of Hájek, Ji Ř Í, 2007, Revision of the genus Eulichas Jacobson, 1913 (Coleoptera: Eulichadidae) I. Introduction, morphology of adults, key to subgenera and species groups, and taxonomy of E. funebris species group, pp. 1-35 in Zootaxa 1620 on pages 24-25, DOI: 10.5281/zenodo.179178
Insight on the interaction between the scorpion toxin blocker Discrepin on potassium voltage-gated channel Kv4.3 by molecular dynamics simulations
Creators: name: Montero-Domínguez, Pavel A.
name: Mares-Sámano, Sergio
name: Garduño-Juárez, Ramón
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
classificationCode: 39999
subject: Chemical Sciences not elsewhere classified
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Discrepin is a 38-residue α-toxin extracted from the venom of the Venezuelan scorpion Tityus discrepans, which inhibits ionic transit in the voltage-dependent potassium channels (Kv) of A-type current. The effect of specific residues on the IC50 between Discrepine and Kv4.3, the main component of A-type currents, is known; however, the molecular details of the toxin-channel interaction are not known. In this work, we present interaction models between Discrepin (wt) and two peptide variants (V6K/D20K and K13A) on the pore-forming domain of the Kv4.3 channel obtained from homology, docking, and molecular dynamics modeling techniques. The free energy calculations in these models correspond to the order of the experimentally determined IC50 values. Our studies shed light on the role of the K13 residue as responsible for occluding the Kv4.3 selectivity filter and the importance of the V6K mutation in the approach and stabilization of toxin-channel complex interactions. Communicated by Ramaswamy H. Sarma
Simultaneous construction of hyperbolic isometries
Creators: name: Clay, Matt
name: Uyanik, Caglar
Publisher: name: arXiv
Year: 2016
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F65, 20E36

description: Given isometric actions by a group G on finitely many δ-hyperbolic metric spaces, we provide a sufficient condition that guarantees the existence of a single element in G that is hyperbolic for each action. As an application we prove a conjecture of Handel and Mosher regarding relatively fully irreducible subgroups and elements in the outer automorphism group of a free group.
description: 18 pages; v2: slight strengthening of main theorem, incorporated comments from referee, to appear in Pacific Journal of Mathematics
A Framework for Extracting Scientific Measurements and Geo-Spatial Information from Scientific Literature
Creators: name: Suryani, Muhammad Asif
name: Wölker, Yannick
name: Sharma, Deepak
name: Beth, Christian
name: Wallmann, Klaus
name: Renz, Matthias
Publisher: name: Zenodo
Year: 2022
Subjects: Information Retrieval,
Measurement Extraction,
Spatial Information,
Marine Geology

description: Research papers are often the primary source of scientific information dissemination, as researchers encapsulate their findings in these documents. Generally such findings are of complex types, diverse expressions and also carry rich context. The traditional approach for extracting certain scientific information from these documents is manual extraction, which is very time consuming. Due to the rapid increase in number of publications, using the full potential of these rich data sources by manual extraction is becoming infeasible. In this paper, we propose a framework for the automatic extraction of targeted (user defined) quantitative information, e.g. temperature sensor values, with its geo-spatial context from scientific documents. Given a database of scientific documents and a targeted user-defined geotagable measurement variables, mass accumulation rate (MAR) and sedimentation rate (SR), the problem we are addressing is to retrieve all the values together with their geo-spatial information respectively. Though there has been done a lot in information retrieval, to the best of our knowledge, this problem has not been explored, yet. We design a novel heterogeneous linking solution, that links measurements with locations, which are found by our tailored extraction pipeline. In experimental studies based on our novel dataset of Marine Geology papers, we showcase the capabilities of our linking framework using common geo-tagable Marine Geology measurements.
Interdisciplinary Study of Hydrodynamic and Biogeochemical Processes of a Large-Scale River Plume
Creators: name: McEwan, Robert
Publisher: name: University of Plymouth
Year: 2013
Subjects: river plume modelling internal waves

description: Full version unavailable due to 3rd party copyright restrictions.
description: This research has utilised the Massachusetts Institute of Technology gen- eral circulation model (MITgcm) along with observations taken as part of the River In uences on Shelf Ecosystems (RISE) study to investigate the dynamic processes associated with the Columbia River plume at different temporal and spatial scales. Firstly, a high resolution ( x= y=25 m) investigation of the near-field plume was undertaken using the fully non-hydrostatic mode of the MITgcm. This resulted in the reproduction of a detailed inner plume as well as a series of radiated internal waves. In addition to first mode internal waves, second order waves were radiated from the plume boundary when propagation ve- locity becomes sub-critical. Third mode internal waves were also observed, trapped at the plume head. The fine plume structure produced revealed sec- ondary fronts within the plume that also generated internal waves. These features increase the mixing occurring inside the plume, resulting in greater entrainment of underlying waters into the plume. The use of Lagrangian drifters within the model produced detailed results of the recirculation tak- ing place within the emerging plume and how this recirculation changes with depth. This has implications for the near-field recirculation of biologically important solutes present in the plume waters. A second coarser resolution horizontal grid ( x= y=500 m) was imple- mented to investigate the processes of the large-scale plume with the addi- tion of wind forcing. Experiments with both simplified and realistic wind scenarios were carried out and comparisons with in-situ data were made. This revealed the dominance of wind effects on the outer plume and tidal effects on the inner plume. In the simplified wind cases, the classical the- ory of plume propagation under the action of upwelling and downwelling favourable winds was recreated. For the case of realistic winds, there was some success in reproducing a hindcast of the plume location. Tracer fields were used to represent nutrient concentrations based on observed data. Whilst these results showed variations from observations, they did allow a spatially and temporally complete view to be taken of nutrient distribu- tion in the region.
Additional file 1 of Prevalence and determinants of self-reported functional status among older adults residing in the largest refugee camp of the world
Creators: name: Anwar, Afsana
name: Yadav, Uday Narayan
name: Huda, Md. Nazmul
name: Rifat, M. A.
name: Ali, ARM Mehrab
name: Mondal, Probal Kumar
name: Rizwan, Abu Ansar Md.
name: Shuvo, Suvasish Das
name: Mistry, Sabuj Kanti
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Supplementary file 1: Area under the receiver operating characteristic (AUROC) curve
title: The risks and opportunities of the EU corporate sustainability due diligence for SMEs
title: Lean checklist and guideline for first mitigation measures
titleType: Subtitle
Creators: name: Blum, Laura
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2023
Subjects: subject: 330 Wirtschaft

description: The presented master thesis of the study subject International Management and Leadership at the University of Applied Science Vorarlberg in Dornbirn handles the potential future influence of the EU Corporate Sustainability Due diligence on SMEs. First this thesis introduces the most important regulations that might come into place with this Due Diligence Act and gives a theoretical input when and how it will come into place, and also who it will affect directly and who will be affected indirectly. The empirical data resulted of several qualitative expert interviews and a following quantitative research. The expert interviews are split in two different groups, first the topic experts from institutions like chamber of commerce or chamber of labour and second experts from highly successful Austrian companies which are already handling the topic and the future challenges. Expected outcome of the qualitative interviews was a better view on the actual situation especially the impact on small and medium enterprises. On the basis of this results the quantitative survey was produced. In the quantitative survey the goal was to see, how much entrepreneurs and companies in the small and medium sector already are aware of the upcoming legal challenges throughout the supply chain. With all this collected data the practical outcome of this thesis is the Checklist, which helps entrepreneurs to find out if and how much they will be affected by the Act. And finally, the most important part is the Guideline, which introduces first risk assessment tools, that will help companies to prepare for future legislation and bring undoubtedly a certain advantage for the upcoming challenges.
Magnetic resonance with squeezed microwaves
Creators: name: Bienfait, A.
name: Campagne-Ibarcq, P.
name: Holm-Kiilerich, A.
name: Zhou, X.
name: Probst, S.
name: Pla, J. J.
name: Schenkel, T.
name: Vion, D.
name: Esteve, D.
name: Morton, J. J. L.
name: Moelmer, K.
name: Bertet, P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Vacuum fluctuations of the electromagnetic field set a fundamental limit to the sensitivity of a variety of measurements, including magnetic resonance spectroscopy. We report the use of squeezed microwave fields, which are engineered quantum states of light for which fluctuations in one field quadrature are reduced below the vacuum level, to enhance the detection sensitivity of an ensemble of electronic spins at millikelvin temperatures.} By shining a squeezed vacuum state on the input port of a microwave resonator containing the spins, we obtain a $1.2$\,dB noise reduction at the spectrometer output compared to the case of a vacuum input. This result constitutes a proof of principle of the application of quantum metrology to magnetic resonance spectroscopy.
description: Main text : 19 pages, 6 figures. Followed by a 18-pages Supplementary Information section, which includes 6 Supplementary Figures
title: Effizienzsteigerung durch Videoidentifizierungsverfahren bei Banken
title: Eine Empfehlung für den Deutschen und Liechtensteiner Banksektor
titleType: Subtitle
Creators: name: Speck, Christopher
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2023
Subjects: subject: 330 Wirtschaft

description: Die sichtbare Digitalisierung des Bankensektors beruht im Kern auf der Steigerung des Qualitätserlebnisses für Kund*innen. Als ein Symbol dessen hat sich das Videoidentifizierungsverfahren etabliert, durch welches ein digitales Onboarding von Neukund*innen in Banken möglich gemacht wird. Gefördert wird die Implementierung dieser Technologie am Markt im Wesentlichen durch den Entwicklungseinsatz von Direktbanken. Das Setup dieses Verfahrens steht im Kontrast zu den Kernelementen – Kundenberatung und physische Eröffnung – welche eng mit klassischen Banken verbunden wird. Digitalisierung hat sich zu einem Synonym von Fortschritt entwickelt, viele positive Aspekte, aber vor allem eine Effizienzsteigerung im Prozesse sind beobachtbar. Erfolge wie unter anderem die geografische Markterweiterung samt einem ertragssteigernden Marktsegment, verbesserte Kundenzufriedenheit und Prozessexzellenz, die den heutigen Anforderungen gerecht wird sind zu verzeichnen. Welche weiteren Chancen und Risiken zwei der bedeutendsten Finanzplätze in Europa – Liechtenstein und Deutschland – im Detail mit dieser Technologie verbinden, ist Ziel dieser Forschungsarbeit, an wessen Ende eine konkrete Handlungsempfehlung kommuniziert werden wird.
Topological Thermal Hall Effect in Frustrated Kagomé Antiferromagnets
Creators: name: Owerre, S. A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In frustrated magnets the Dzyaloshinsky-Moriya interaction arising from spin-orbit coupling can induce a magnetic long-range order. Here, we report a theoretical prediction of thermal Hall effect in frustrated kagomé magnets such as KCr$_3$(OH)$_6$(SO4)$_2$ and KFe$_3$(OH)$_{6}$(SO$_{4}$)$_2$. The thermal Hall effects in these materials are induced by scalar spin chirality as opposed to DMI in previous studies. The scalar spin chirality originates from magnetic-field-induced chiral spin configuration due to non-coplanar spin textures, but in general it can be spontaneously developed as a macroscopic order parameter in chiral quantum spin liquids. Therefore, we infer that there is a possibility of thermal Hall effect in frustrated kagomé magnets such as herbertsmithite ZnCu$_3$(OH)$_6$Cl$_2$ and the chromium compound Ca$_{10}$Cr$_7$O$_{28}$, although they also show evidence of magnetic order in the presence of a magnetic field or pressure.
description: 6 pages, 5 figures. PRB Accepted
Stepwise Behavior of Vortex-Lattice Melting Transition in Tilted Magnetic Fields in Single Crystals of Bi2Sr2CaCu2O8 + delta
Creators: name: Kadowaki, K.
name: Mirkovic, J.
name: Savelev, S. E.
name: Sugahara, E.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
(200771) Frederick James Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.