cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Variation of the essential oil components of Citrus aurantium leaves upon using different distillation techniques and evaluation of their antioxidant, antidiabetic, and neuroprotective effect against Alzheimer’s disease
Creators: name: Elhawary, Esraa A.
name: Nilofar, Nilofar
name: Zengin, Gokhan
name: Eldahshan, Omayma A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Supplementary Material 1
Engaging in a home-based exercise program: a mixed-methods approach to identify motivators and barriers for individuals with stroke
Creators: name: Bhattacharjya, Sutanuka
name: Linares, Isabelle
name: Langan, Jeanne
name: Xu, Wenyao
name: Subryan, Heamchand
name: Cavuoto, Lora Anne
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Community-dwelling individuals with chronic stroke used a novel, portable rehabilitation system, mRehab, that uses a smartphone app coupled with 3D printed objects resembling daily use items. The objectives of this study include evaluating participant’s approach and nature of engagement with mRehab and identifying factors that influenced the users’ engagement with mRehab. An explanatory mixed-method approach was used. In the first phase, 16 participants used mRehab at home for six weeks; six participants were recruited from the first phase for in-depth interviews. Participants were categorized into High, Moderate, and Low Frequency groups based on their frequency of mRehab use. High frequency of use was not related to improved performance on clinical assessments; instead, High Frequency users more commonly initiated performance of new activities after the mRehab program compared to participants with lower frequency of use. Useful activities that are challenging and meaningful to the participants, and availability of objective feedback for self-monitoring were some of the motivators for mRehab use. Difficulty with time management, lack of caregiver availability, and difficulties with the design of the system posed as barriers to mRehab use. Tailoring home programs to the recipients’ needs including perceived meaningfulness of the activities is key for long-term rehabilitation.
Evolution of the Major Merger Galaxy Pair Fraction at z < 1
Creators: name: Keenan, R. C.
name: Foucaud, S.
name: De Propris, R.
name: Hsieh, B. C.
name: Lin, L.
name: Chou, R. C. Y.
name: Huang, S.
name: Lin, J. H.
name: Chang, K. H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a study of the largest available sample of near-infrared selected (i.e., stellar mass selected) dynamically close pairs of galaxies at low redshifts ($z<0.3$). We combine this sample with new estimates of the major-merger pair fraction for stellar mass selected galaxies at $z<0.8$, from the Red Sequence Cluster Survey (RCS1). We construct our low-redshift $K-$band selected sample using photometry from the UKIRT Infrared Deep Sky Survey (UKIDSS) and the Two Micron All Sky Survey (2MASS) in the $K-$band ($\sim 2.2~μ$m). Combined with all available spectroscopy, our $K-$band selected sample contains $\sim 250,000$ galaxies and is $> 90\%$ spectroscopically complete. The depth and large volume of this sample allow us to investigate the low-redshift pair fraction and merger rate of galaxies over a wide range in $K-$band luminosity. We find the major-merger pair fraction to be flat at $\sim 2\%$ as a function of $K-$band luminosity for galaxies in the range $10^8 - 10^{12} L_{\odot}$, in contrast to recent results from studies in the local group that find a substantially higher low-mass pair fraction. This low-redshift major-merger pair fraction is $\sim 40-50\%$ higher than previous estimates drawn from $K-$band samples, which were based on 2MASS photometry alone. Combining with the RCS1 sample we find a much flatter evolution ($m = 0.7 \pm 0.1$), in the relation $f_{\rm{pair}} \propto (1+z)^m$, than indicated in many previous studies. These results indicate that a typical $L\sim L^*$ galaxy has undergone $\sim 0.2-0.8$ major mergers since $z=1$ (depending on the assumptions of merger timescale and percentage of pairs that actually merge).
description: Revised to match the version accepted to ApJ
RICE BZIP TRANSCRIPTION FACTORS REGULATE THE FLORAL TRANSITION VIA FORMATION OF FLORIGEN ACTIVATION COMPLEXES (FACS)
Creators: name: CERISE, MARTINA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: When external and internal cues are favorable, rice plants stop to produce leaves and start to make flowers. This process is called floral transition and occurs in leaves and at the Shoot Apical Meristem (SAM). In rice, Heading Date 3a (Hd3a) and RICE FLOWERING LOCUS T 1 (RFT1) are two signal molecules, called florigens, which are expressed and translated in leaves. Florigens are small and globular proteins with non-cell autonomous functions, as they can move via the vascular tissue of rice and arrive in the SAM, where they promote the transition from the vegetative to the reproductive phase. In this tissue they bind the FD-like bZIP transcription factor OsFD1 thanks to the help of Gf14c, which bridges their interaction, and they form the Florigen Activation Complex (FAC). OsMADS14 and OsMADS15 are FAC targets and they are required for proper flower development. 5 Because the florigens cannot bind the DNA alone, FD-like bZIPs have a crucial role during the floral transition. For this reason, we focused on FACs formation and we characterized different bZIPs involved in the floral transition. We found that in leaves OsFD1-FAC regulates flowering time via positive feedback loops on Hd3a and RFT1 expression. We then characterized OsHBF1, a FD-like bZIP, which generates a negative feedback loop on florigens production via OsHBF1-FAC formation. We isolated the bZIP OsFD4 which promotes the floral transition in the SAM in parallel to OsFD1. OsFD4 interacts with Hd3a and RFT1 in FACs and regulates the expression of OsMADS14 and OsMADS15, such as OsFD1-FAC does. Finally, we performed DAP-sequencing with OsFD1, OsFD4 and OsHBF1 to analyze differences among these bZIPs and to find their targets. Results indicate that bZIPs bind the same consensus motif, but the distance between two motives varies depending on the bZIP considered, suggesting that it could be causal to their different role during the floral transition.
Cockayne syndrome group B protein enhances elongation by RNA polymerase II
Creators: name: Sancar, A.
name: Selby, C. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Cockayne syndrome (CS) is characterized by impaired physical and mental development. Two complementation groups, CSA and CSB, have been identified. Here we report that the CSB gene product enhances elongation by RNA polymerase II. CSB stimulated the rate of elongation on an undamaged template by a factor of about 3. A thymine-thymine cyclobutane dimer located in the template strand is known to be a strong block to transcription. Addition of CSB to the blocked polymerase resulted in addition of one nucleotide to the nascent transcript. Finally, addition of transcription factor IIS is known to cause polymerase blocked at a thymine-thymine cyclobutane dimer to digest its nascent transcript, and CSB counteracted this transcript shortening action of transcription factor IIS. Thus a deficiency in transcription elongation may contribute to the CS phenotype.
Impacts of the Images of a Dead Gunshot Victim and a “Good Guy With a Gun” Toward Opinions About Gun Regulation
Creators: name: Thomas, Jacob Richard
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Legal Studies
subject: Social Psychology
subject: Sociology
subject: FOS: Sociology
subject: Race and Ethnicity
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Political Science
subject: FOS: Political science
subject: Medicine and Health
subject: Criminology and Criminal Justice
subject: Politics and Social Change

description: During recent mass shootings in the US, one image that is so socially taboo that it remains highly censored by society in news media. These are photographs of wounded and dead victims and videos of the shootings. Far more abundant however are decades of fictional cinematic representations in Hollywood action movies of “good guys with guns” rescuing or avenging helpless others. The National Rifle Association repeatedly claims such only such “good guys with a gun” can stop “a bad with a gun” despite Federal Bureau of Investigation data and public health research proving that bystanders and even trained security professionals only rarely stop gunmen. Due to the widespread influence of this unproven discourse and reports of legal requests by journalists to obtain photographs of wounded children from family members, in this paper drawing on an online sample of over 2000 Americans I experimentally demonstrate to what extent images of wounded children and a video of a “good guy with a gun stopping a bad guy with a gun” might individually and jointly have a causal impact on public opinion about the regulation of guns in US society, and how key covariates like partisanship, conservative ideology, ethnocentrism, authoritarianism, region, consumption of Hollywood action movies, and racial resentment moderate the treatment effect. I hypothesize those who see the image of the child will be less opposed to gun regulations and those who see a bystander use their gun to scare away a bad guy from a store will be more opposed to gun regulations, relative to a control group that sees neither of these visual stimuli.
FUNZIONE DEL BOSCO NELLA FASE DI ARRESTO DEI DEBRIS FLOW
Creators: name: MORLOTTI, EMANUELE
Publisher: name: Universit� degli Studi di Milano
Year: 2010

description: Debris flows, a flowing mixture of sediments, water, air and other materials, are one of the most destructive events in mountain areas: damaged buildings, interrupted infrastructures, fatalities are only some examples of their effects . In Northern Italy, for example, 36% of fatality events in the field of hydro-geo-morphological hazards is represented by debris flows. Alluvial fans, which have been just built by debris flow events occurred in the past, in fact, are areas where human activities (homes, factories, etc.) have always been developed. People living in mountain areas, in this way, must adopt expensive and impacting technical devices to prevent or to mitigate this phenomena. When the magnitude of debris flow is quite small, the protective capability of forests can be used to mitigate their destructive power. Due to the cost and to the environmental impact associated to the technical works, public administration in some areas of the Alps developed knowledge and guidelines to manage forests in a protection perspective. Few studies concerning the quantification of the protection effect, however, have been carried out especially for debris flow phenomena. In the present work small scale tests have been carried out in order to quantify the wood?s effect in the process of debris flows deposition. Results, in particular, show that trees can significantly influence deposit?s run out and area (two of the main debris flow?s deposition parameters), if their density is appropriate with respect to debris flow characteristics. Such evidence should represent the starting point for future researches which aspire to develop guidelines for protection forest?s maintenance in mountain areas.
Auferstehung
Creators: name: Torres Queiruga, Andrés
name: Susin, Luiz Carlos
name: Sobrino, Jon
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 42 Nr. 5 (2006): Concilium: Internationale Zeitschrift für Theologie, Band 42, Heft 5
Assessing the impact of space weather on the electric power grid based on insurance claims for industrial electrical equipment
Creators: name: Schrijver, Carolus J.
name: Dobbins, Robert
name: Murtagh, William
name: Petrinec, Stephen M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Geomagnetically induced currents are known to induce disturbances in the electric power grid. Here, we perform a statistical analysis of 11,242 insurance claims from 2000 through 2010 for equipment losses and related business interruptions in North-American commercial organizations that are associated with damage to, or malfunction of, electrical and electronic equipment. We find that claims rates are elevated on days with elevated geomagnetic activity by approximately 20% for the top 5%, and by about 10% for the top third of most active days ranked by daily maximum variability of the geomagnetic field. When focusing on the claims explicitly attributed to electrical surges (amounting to more than half the total sample), we find that the dependence of claims rates on geomagnetic activity mirrors that of major disturbances in the U.S. high-voltage electric power grid. The claims statistics thus reveal that large-scale geomagnetic variability couples into the low-voltage power distribution network and that related power-quality variations can cause malfunctions and failures in electrical and electronic devices that, in turn, lead to an estimated 500 claims per average year within North America. We discuss the possible magnitude of the full economic impact associated with quality variations in electrical power associated with space weather.
description: 9 pages, 11 figures
Gene 4 helicase of bacteriophage T7 mediates strand transfer through pyrimidine dimers, mismatches, and nonhomologous regions
Creators: name: Griffith, J. D.
name: Richardson, C. C.
name: Kong, D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: In bacteriophage T7 the gene 2.5 single-stranded DNA-binding protein and the gene 4 helicase together promote the annealing of homologous regions of two DNA partners to form a joint molecule and subsequent strand transfer. In this reaction T7 gene 2.5 protein is essential for joint molecule formation, but is not required for T7 gene 4 protein-mediated strand transfer. T7 gene 4 helicase alone is able to mediate strand transfer, provided that a joint molecule is available. The present paper shows that, in addition, strand transfer proceeds at a normal rate even when both DNA partners contain ultraviolet-induced pyrimidine dimers (0.6 dimer per 100 nt). An insert of a relatively long (842-nt) segment of nonhomologous DNA in the single-stranded DNA partner has no effect on strand transfer, whereas its presence in the double-stranded partner prevents strand transfer. A short insert (37 nt) can be tolerated in either partner. Thus, DNA helicase is able to participate in recombinational DNA repair through its role in strand exchange, providing a pathway distinct from nucleotide excision repair.
Additional file 1 of Reducing agalsidase beta infusion time in Fabry patients: low incidence of antibody formation and infusion-associated reactions in an Italian multicenter study
Creators: name: Mignani, Renzo
name: Americo, Claudio
name: Aucella, Filippo
name: Battaglia, Yuri
name: Cianci, Vittoria
name: Sapuppo, Annamaria
name: Lanzillo, Chiara
name: Pennacchiotti, Fabio
name: Tartaglia, Luciano
name: Marchi, Giacomo
name: Pieruzzi, Federico
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Appendix: quality of life survey
Methodological and reporting quality of qualitative evidence in the field of lower limb orthoses: a systematic review
Creators: name: Shahabi, Saeed
name: Lankarani, Kamran Bagheri
name: Hoseeinabadi, Mostafa
name: Heydari, Seyed Taghi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: This study aimed to assess the methodological and reporting quality of qualitative studies conducted in the field of lower limb orthoses (LLOs). The following electronic databases were searched from inception to 2022: PubMed, Scopus, ProQuest, WoS, Embase, the Cochrane Central Register of Controlled Trials, and RehabData. Two authors independently screened and selected the potential studies. The methodological quality of included studies was assessed using the Critical Appraisal Skills Programs qualitative checklist. In addition, the reporting quality of included studies was assessed using the Standards for Reporting Qualitative Research (SRQR) tool. The mean methodological quality score of included studies was 8 (from min = 2 to max = 9.5), and most of the studies had a score of more than 7.5. However, SRQR findings revealed that the overall reporting quality of included studies was not desirable in that the mean score was about 15.44 (from min = 6 to max = 19.5) out of 21. In total, the methodological quality of qualitative studies published in the field of LLOs was moderate. Further, the adherence of these studies to available reporting guidelines was unsatisfactory. As a result, when designing, performing, and reporting qualitative investigations, authors should pay more attention to these criteria.
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
Creators: name: Reddick, R. L.
name: Smithies, O.
name: Fox, J. E.
name: Kim, R.
name: Kim, H.-S.
name: Maeda, N.
name: Milgram, S. L.
name: Rockman, H. A.
name: Oliver, P. M.
name: Pandey, K. N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Natriuretic peptides, produced in the heart, bind to the natriuretic peptide receptor A (NPRA) and cause vasodilation and natriuresis important in the regulation of blood pressure. We here report that mice lacking a functional Npr1 gene coding for NPRA have elevated blood pressures and hearts exhibiting marked hypertrophy with interstitial fibrosis resembling that seen in human hypertensive heart disease. Echocardiographic evaluation of the mice demonstrated a compensated state of systemic hypertension in which cardiac hypertrophy and dilatation are evident but with no reduction in ventricular performance. Nevertheless, sudden death, with morphologic evidence indicative in some animals of congestive heart failure and in others of aortic dissection, occurred in all 15 male mice lacking Npr1 before 6 months of age, and in one of 16 females in our study. Thus complete absence of NPRA causes hypertension in mice and leads to cardiac hypertrophy and, particularly in males, lethal vascular events similar to those seen in untreated human hypertensive patients.
Comparing the effects of medical cannabis for chronic pain patients with and without co-morbid anxiety: A cohort study
Creators: name: Bapir, Lara
name: Erridge, Simon
name: Nicholas, Martha
name: Pillai, Manaswini
name: Dalavaye, Nishaanth
name: Holvey, Carl
name: Coomber, Ross
name: Hoare, Jonathan
name: Khan, Shaheen
name: Weatherall, Mark W
name: Rucker, James J
name: Platt, Michael
name: Sodergren, Mikael H
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: There is growing evidence on the efficacy of cannabis-based medicinal products (CBMPs) for chronic pain (CP). Due to the interaction between CP and anxiety, and the potential impact of CBMPs on both anxiety and CP, this article aimed to compare the outcomes of CP patients with and without co-morbid anxiety following CBMP treatment. Participants were prospectively enrolled and categorized by baseline General Anxiety Disorder-7(GAD-7) scores, into ‘no anxiety’(GAD-7 < 5) and ‘anxiety’(GAD-7 ≥ 5) cohorts. Primary outcomes were changes in Brief Pain Inventory Short-Form, Short-form McGill Pain Questionnaire-2, Pain Visual Analogue Scale, Sleep Quality Scale (SQS), GAD-7 and EQ-5D-5L index values at 1, 3 and 6 months. 1254 patients (anxiety = 711; no anxiety = 543) met inclusion criteria. Significant improvements in all primary outcomes were observed at all timepoints (p < 0.050), except GAD-7 in the no anxiety group(p > 0.050). The anxiety cohort reported greater improvements in EQ-5D-5L index values, SQS and GAD-7(p < 0.050), but there were no consistent differences in pain outcomes. A potential association between CBMPs and improvements in pain and health-related quality of life (HRQoL) in CP patients was identified. Those with co-morbid anxiety reported greater improvements in HRQoL.
Additional file 1 of The impact of education/training on nurses caring for patients with stroke: a scoping review
Creators: name: Zhao, Yanjie
name: Xu, Yuezhen
name: Ma, Dongfei
name: Fang, Shuyan
name: Zhi, Shengze
name: He, Meng
name: Zhu, Xiangning
name: Dong, Yueyang
name: Song, DongPo
name: Yiming, Atigu
name: Sun, Jiao
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Appendix A provides the full list of search terms.
The Strominger-Yau-Zaslow conjecture and its impact
Creators: name: Chan, Kwokwai
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics

description: This article surveys the development of the SYZ conjecture since it was proposed by Strominger, Yau and Zaslow in their famous 1996 paper, and discusses how it has been leading us to a thorough understanding of the geometry underlying mirror symmetry.
description: v2: minor corrections in Section 8; 22 pages. appears in "Selected Expository Works of Shing-Tung Yau with Commentary. Vol. II", 1183-1208, Adv. Lect. Math. (ALM) 29, Int. Press, Somerville, MA, 2014
Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants
Creators: name: Chin, K.-C.
name: Ting, J. P.- Y.
name: Li, G. G.- X.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The class II transactivator (CIITA) is a master transcription regulator of gene products involved in the exogenous antigen presentation pathway, including major histocompatibility complex (MHC) class II, invariant chain, and DM. An extensive analysis of the putative functional domains of CIITA is undertaken here to explore the action of CIITA. Antibodies to CIITA protein were produced to verify that these mutant proteins are expressed. Both acidic and proline/serine/threonine-rich domains are essential for class II MHC promoter activation. In addition, three guanine nucleotide-binding motifs are essential for CIITA activity. Of these mutants, two exhibited strong transdominant-negative functions. These two mutants provide a plausible approach to manipulate MHC class II expression and immune responses.
Density of the set of endomorphisms with a maximizing measure supported on a periodic orbit
Creators: name: Batista, Tatiane Cardoso
name: Gonschorowski, Juliano dos Santos
name: Tal, Fabio Armando
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: Let $M$ be a compact $n$-dimensional Riemanian manifold, End($M$) the set of the endomorphisms of $M$ with the usual $\mathcal{C}^0$ topology and $ϕ: M\to\mathbb{R}$ continuous. We prove that there exists a dense subset of $\mathcal{A}$ of End($M$) such that, if $f\in\mathcal{A}$, there exists a $f$ invariant measure $μ_{\max}$ supported on a periodic orbit that maximizes the integral of $ϕ$ among all $f$ invariant Borel probability measures.
description: To appear in Discrete Contin. Dyn. Sys. - A
Diffuse X-ray emission from the superbubbles N 70 and N 185 in the Large Magellanic Cloud
Creators: name: Reyes-Iturbide., Jorge
name: Rosado., Margarita
name: Rodríguez-González., Ary
name: Velázquez., Pablo F.
name: Sánchez-Cruces, Mónica
name: Ambrocio-Cruz, Patricia
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present a study of the diffuse X-ray emission from superbubbles N 70 (DEM L301) and N 185 (DEM L25) located in the Large Magellanic Cloud, based on data from the XMM-Newton Satellite. We obtained spectra and images of these objects in the soft X-ray energy band. These X-ray spectra were fitted by a thermal plasma model, with temperatures of $2.6 \times 10^{6}$ K and $2.3 \times 10^{6}$ K, for N 70 and N 185, respectively. For N 70, images show that X-ray emission comes from the inner regions of the superbubble, when we compare the distribution of the X-ray and the optical emission; while for N 185, the X-ray emission is partially confined by the optical shell. We suggest that the observed X-ray emission is caused by shock-heated gas, inside of the optical shells. We also obtained X-ray luminosities which exceed the values predicted by the standard analytical model. This fact shows that, in addition to the winds of the interior stars, it is necessary to consider another ingredient in the description, such as a supernova explosion, as has been proposed in previous numerical models.
description: 9 pages, 7 figures. Accepted for publication in AJ
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
Creators: name: Kung, H. C.
name: Reardon, J. T.
name: Sancar, A.
name: Bessho, T.
name: Bolton, P. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Xeroderma pigmentosum (XP) patients fail to remove pyrimidine dimers caused by sunlight and, as a consequence, develop multiple cancers in areas exposed to light. The second most common sign, present in 20–30% of XP patients, is a set of neurological abnormalities caused by neuronal death in the central and peripheral nervous systems. Neural tissue is shielded from sunlight-induced DNA damage, so the cause of neurodegeneration in XP patients remains unexplained. In this study, we show that two major oxidative DNA lesions, 8-oxoguanine and thymine glycol, are excised from DNA in vitro by the same enzyme system responsible for removing pyrimidine dimers and other bulky DNA adducts. Our results suggest that XP neurological disease may be caused by defective repair of lesions that are produced in nerve cells by reactive oxygen species generated as by-products of an active oxidative metabolism.
Additional file 1 of Risk of venous thromboembolism in patients with rheumatoid arthritis: a meta-analysis of observational studies
Creators: name: Fazal, Zahra A
name: Avina-Galindo, Ana Michelle
name: Marozoff, Shelby
name: Kwan, Jessie
name: Lu, Na
name: Avina-Zubieta, J. Antonio
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
Work ethic in formerly socialist economies
Creators: name: Linz, S
name: Chu, Yu-Wei
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: Do younger workers in transition economies have a different work ethic from those who were trained and employed in the former socialist economy? Is there a positive link between work ethic and earnings among workers in transition economies? We address these questions using data collected from employee surveys conducted in Armenia, Azerbaijan, Kazakhstan, Kyrgyzstan, Russia, and Serbia. Employing a composite measure, we find that younger workers tend to adhere more strongly, and older workers less strongly. This result is obtained in the majority of cases for the individual work ethic components, as well. We also find work ethic adherence is stronger among men than women, among supervisors, and among participants who exhibit an internal locus of control. The link between work ethic and earnings is positive: participants who scored highest on the work ethic measure earn 15% more than those who scored lowest. Commonalities across these six culturally and economically diverse countries provide a foundation for developing a more global perspective of work ethic and worker performance. © 2013 Elsevier B.V.
Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity
Creators: name: Clements, V. K.
name: Ting, J. P.- Y.
name: Martin, B. K.
name: Armstrong, T. D.
name: Ostrand-Rosenberg, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: We have developed an immunotherapy in which tumor cells transfected with syngeneic major histocompatibility complex (MHC) class II genes are cell-based vaccines for the treatment of established tumor and metastatic disease. If this strategy is to be used clinically, convenient methods for generating class II+ tumor cells are necessary. Interferon-γ treatment or transduction of the class II transactivator (CIITA) gene induces class II expression but also up-regulates the class II-associated accessory molecules, invariant chain (Ii) and DM. To determine if interferon-γ treatment and CIITA transduction are potential immunotherapies, we assessed the tumorigenicity of sarcoma cells expressing combinations of class II, Ii, and DM. Since we hypothesized that class II-transfected tumor cells not coexpressing Ii and DM present endogenously encoded tumor peptides, we have assessed the transfectants for antigen presentation activity to MHC class II-restricted antigen-specific CD4+ T cells. Tumor challenge studies demonstrate that tumor cells expressing class II without coexpression of Ii or Ii plus DM are highly immunogenic and preferentially present endogenous antigens, while tumors coexpressing class II with Ii or Ii plus DM are not effective immunogens. Because tumor rejection correlates with expression of class II without coexpression of Ii and DM, the most efficacious vaccines will express MHC class II without coexpression of Ii and DM and will preferentially present endogenous antigen.
Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment
Creators: name: Proia, R. L.
name: Crawley, J. N.
name: Hoffmann, A.
name: Westphal, H.
name: Suzuki, K.
name: Sandhoff, K.
name: Liu, Y.
name: Miller, K. M.
name: McDonald, M. P.
name: Grinberg, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The GM2 activator deficiency (also known as the AB variant), Tay–Sachs disease, and Sandhoff disease are the major forms of the GM2 gangliosidoses, disorders caused by defective degradation of GM2 ganglioside. Tay–Sachs and Sandhoff diseases are caused by mutations in the genes (HEXA and HEXB) encoding the subunits of β-hexosaminidase A. The GM2 activator deficiency is caused by mutations in the GM2A gene encoding the GM2 activator protein. For degradation of GM2 ganglioside by β-hexosamindase A, the GM2 activator protein must participate by forming a soluble complex with the ganglioside. In each of the disorders, GM2 ganglioside and related lipids accumulate to pathologic levels in neuronal lysosomes, resulting in clinically similar disorders with an onset in the first year of life, progressive neurodegeneration, and death by early childhood. We previously have described mouse models of Tay–Sachs (Hexa −/−) and Sandhoff (Hexb −/−) diseases with vastly different clinical phenotypes. The Hexa −/− mice were asymptomatic whereas the Hexb −/− mice were severely affected. Through gene disruption in embryonic stem cells we now have established a mouse model of the GM2 activator deficiency that manifests an intermediate phenotype. The Gm2a −/− mice demonstrated neuronal storage but only in restricted regions of the brain (piriform, entorhinal cortex, amygdala, and hypothalamic nuclei) reminiscent of the asymptomatic Tay–Sachs model mice. However, unlike the Tay–Sachs mice, the Gm2a −/− mice displayed significant storage in the cerebellum and defects in balance and coordination. The abnormal ganglioside storage in the Gm2a −/− mice consisted of GM2 with a low amount of GA2. The results demonstrate that the activator protein is required for GM2 degradation and also may indicate a role for the GM2 activator in GA2 degradation.
Pore size of the malaria parasite's nutrient channel
Creators: name: Desai, S. A.
name: Rosenberg, R. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The malaria parasite, Plasmodium falciparum, requires large amounts of nutrients to sustain its rapid growth within the human red blood cell. A recently identified ion channel on the surface of the intraerythrocytic parasite may provide direct access to these nutrients in the red blood cell cytosol. Evidence supporting this role was obtained by incorporating this channel into planar lipid bilayers. In bilayers, this channel has conductance and gating properties identical to the in situ channel, passes soluble macromolecules of up to 1400 Da, and functions as a high capacity, low affinity molecular sieve. These properties, remarkably similar to those of a pore on Toxoplasma gondii (another protozoan parasite causing human disease), suggest a novel class of channels used by these intracellular parasites to acquire nutrients from host cytosol.
Additional file 1 of Effects of aquatic exercise program versus on-land exercise program on cancer-related fatigue, neuropathy, activity and participation, quality of life, and return to work for cancer patients: study protocol for a randomized controlled trial
Creators: name: Nissim, Michal
name: Rottenberg, Yakir
name: Karniel, Naama
name: Ratzon, Navah Z.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Quantum Corrections in Galileons from Matter Loops
Creators: name: Heisenberg, Lavinia
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Galileon interactions represent a class of effective field theories that have received much attention since their inception. They can be treated in their own right as scalar field theories with a specific global shift and Galilean symmetry or as a descendant of a more fundamental theory like massive gravity. It is well known that the Galileon theories are stable under quantum corrections thanks to the non-renormalization theorem which is not due to the symmetry. We consider different covariant couplings of this Galileon scalar field with the matter field: the conformal coupling, the disformal coupling and the longitudinal coupling. We compute the one-loop quantum corrections to the Galileon interactions from the coupling to the external matter fields. In all the considered cases of covariant couplings we show that the terms generated by one-loop matter corrections not only renormalize the Galileon interactions but also give rise to higher order derivative ghost interactions. However, the renormalized version of the Galileon interactions as well as the new interactions come at a scale suppressed by the original classical coupling scale and hence are harmless within the regime of validity of the effective field theory.
description: 25 pages, journal version & references added
Potential and prospects for utilization of avocado by-products in integrated biorefineries
Creators: name: Rodríguez-Martínez, Beatriz
name: Romaní, Aloia
name: Eibes, Gemma
name: Garrote, Gil
name: Gullón, Beatriz
name: Del-Río, Pablo
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 40
subject: Engineering

description: The industrial processing of avocado to extract oil, and produce guacamole or sauces generates enormous quantities of peels and seeds (around 2 million tons worldwide in 2019) without commercially valuable applications. However, various studies have suggested the presence of a wide range of interesting compounds in the composition of these by-products. This review depicts a thorough outline of the capacity of avocado residues to be converted into a portfolio of commodities that can be employed in sectors such as the food, cosmetics, pharmaceuticals, environment, and energy industries. Therefore, a novel biorefinery strategy to valorize avocado-processing residues to obtain a polyphenolic extract, pectooligosaccharides, and succinic acid was presented. Additionally, the prospects and challenges facing a biorefinery based on the valorization of avocado residues are presented, particularly its techno-economic feasibility on an industrial scale, aiming for a resource-efficient circular bio-economy.
Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster
Creators: name: Gilbert, L. I.
name: Lee, C. C.
name: Kim, A.-J.
name: Kim, K.
name: Cha, G.-H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The prothoracicotropic hormone (PTTH) of Drosophila melanogaster is a modulator of ecdysteroid (molting hormone) synthesis and was isolated and characterized from extracts of whole larvae (≈4 × 105 larvae). The purification protocol included delipidation, salt-extraction, heat treatment, conventional column chromatography, and HPLC, and yielded about 50 μg of pure hormone. Biological activity was followed using a ring gland in vitro assay in which ecdysteroidogenesis by control ring glands as measured by radioimmunoassay was compared with ring gland incubations containing active fractions. The molecular weight of the purified PTTH was 45 kDa and N-terminal amino acid sequence analysis indicated that those analyzed sequences displayed no significant homology with known peptides or peptide hormones, including PTTH from the silkmoth, Bombyx mori. Western blot analysis indicated that the native form of Drosophila PTTH was a single 66-kDa polypeptide with N-linked carbohydrate chains and intrachain disulfide bonds. The purified 45-kDa peptide is the deglycosylated form, a result of glycosidase activity present during preparation of the PTTH extract. The deglycosylated form shows heterogeneity, presumably as a result of varying degrees of deglycosylation at the N terminus.
Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions
Creators: name: Booker, J.
name: Roof, K.
name: Maynor, K.
name: Borrero, M.
name: Cohen, P. L.
name: Reap, E. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The lpr gene encodes a defective form of Fas, a cell surface protein that mediates apoptosis. This defect blocks apoptotic deletion of autoreactive T and B cells, leading to lymphoproliferation and lupus-like autoantibody production. The effects of the lpr Fas mutation on other kinds of physiologically relevant apoptosis are largely undocumented. To assess whether some of the apoptosis known to occur after ionizing radiation might be mediated by Fas/Fas ligand (FasL) interactions, we quantitated in vitro apoptosis by flow cytometry measurement of DNA content in splenic T and B cells from irradiated 5- to 8-month-old B6/lpr mice. Total apoptosis of both lpr and control cells was substantial after treatment; however there was a significant difference between B6 (73%) and lpr (25%) lymphocyte apoptosis. Thy1, CD4, CD8, and IgM cells from lpr showed much lower levels of apoptosis than control cells after irradiation. Apoptosis induced by heat shock was also impaired in lpr. The finding that γ-irradiation increased Fas expression on B6 cells and that irradiation-induced apoptosis could be blocked with a Fas–Fc fusion protein further supported the possible involvement of Fas in this form of apoptosis. Fas/FasL interactions may thus play an important role in identifying and eliminating damaged cells after γ-irradiation and other forms of injury.
Für die Inkulturation der Glaubenslehre in das afrikanische Christentum
Creators: name: Santedi Kinkupu, Léonard
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 42 Nr. 4 (2006): Concilium: Internationale Zeitschrift für Theologie, Band 42, Heft 4
Limits on low frequency radio emission from southern exoplanets with the Murchison Widefield Array
Creators: name: Murphy, Tara
name: Bell, Martin E.
name: Kaplan, David L.
name: Gaensler, B. M.
name: Offringa, Andre R.
name: Lenc, Emil
name: Hurley-Walker, Natasha
name: Bernardi, G.
name: Bowman, J. D.
name: Briggs, F.
name: Cappallo, R. J.
name: Corey, B. E.
name: Deshpande, A. A.
name: Emrich, D.
name: Goeke, R.
name: Greenhill, L. J.
name: Hazelton, B. J.
name: Hewitt, J. N.
name: Johnston-Hollitt, M.
name: Kasper, J. C.
name: Kratzenberg, E.
name: Lonsdale, C. J.
name: Lynch, M. J.
name: McWhirter, S. R.
name: Mitchell, D. A.
name: Morales, M. F.
name: Morgan, E.
name: Oberoi, D.
name: Ord, S. M.
name: Prabu, T.
name: Rogers, A. E. E.
name: Roshi, D. A.
name: Shankar, N. Udaya
name: Srivani, K. S.
name: Subrahmanyan, R.
name: Tingay, S. J.
name: Waterson, M.
name: Wayth, R. B.
name: Webster, R. L.
name: Whitney, A. R.
name: Williams, A.
name: Williams, C. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present the results of a survey for low frequency radio emission from 17 known exoplanetary systems with the Murchison Widefield Array. This sample includes 13 systems that have not previously been targeted with radio observations. We detected no radio emission at 154 MHz, and put 3 sigma upper limits in the range 15.2-112.5 mJy on this emission. We also searched for circularly polarised emission and made no detections, obtaining 3 sigma upper limits in the range 3.4-49.9 mJy. These are comparable with the best low frequency radio limits in the existing literature and translate to luminosity limits of between 1.2 x 10^14 W and 1.4 x 10^17 W if the emission is assumed to be 100% circularly polarised. These are the first results from a larger program to systematically search for exoplanetary emission with the MWA.
description: Accepted for publication in MNRAS. Updated author list from last revision
Spectra generated by a confined softcore Coulomb potential
Creators: name: Hall, Richard L
name: Saad, Nasser
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Analytic and approximate solutions for the energy eigenvalues generated by a confined softcore Coulomb potentials of the form a/(r+β) in d>1 dimensions are constructed. The confinement is effected by linear and harmonic-oscillator potential terms, and also through `hard confinement' by means of an impenetrable spherical box. A byproduct of this work is the construction of polynomial solutions for a number of linear differential equations with polynomial coefficients, along with the necessary and sufficient conditions for the existence of such solutions. Very accurate approximate solutions for the general problem with arbitrary potential parameters are found by use of the asymptotic iteration method.
description: 17 pages, 2 figures
Laws, Policies, and Collective Agreements Protecting Low-wage and Digital Platform Workers During the COVID-19 Pandemic
Creators: name: MacEachen, Ellen
name: de Rijk, Angelique
name: Dyreborg, Johnny
name: Fassier, Jean-Baptiste
name: Fletcher, Michael
name: Hopwood, Pamela
name: Koivusalo, Meri
name: Majowicz, Shannon
name: Meyer, Samantha
name: Ståhl, Christian
name: Welti, Felix
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: Uncategorized

description: In the context of the COVID-19 pandemic, this commentary describes and compares shifting employment and occupational health social protections of low-wage workers, including self-employed digital platform workers. Through a focus on eight advanced economy countries, this paper identifies how employment misclassification and definitions of employees were handled in law and policy. Debates about minimum wage and occupational health and safety standards as they relate to worker well-being are considered. Finally, we discuss promising changes introduced during the COVID-19 pandemic that protect the health of low-wage and self-employed workers. Overall, we describe an ongoing “haves” and a “have not” divide, with on the one extreme, traditional job arrangements with good work-and-health social protections and, on the other extreme, low-wage and self-employed digital platform workers who are mostly left out of schemes. However, during the pandemic small and often temporary gains occurred and are discussed.
On The Reliability Of Machine Learning Applications In Manufacturing Environments
Creators: name: Nicolas Jourdan
name: Sagar Sen
name: Erik Johannes Husom
name: Enrique Garcia-Ceja
name: Tobias Biegel
name: Joachim Metternich
Publisher: name: Zenodo
Year: 2023

description: The increasing deployment of advanced digital technologies such as Internet of Things (IoT) devices and Cyber-Physical Systems (CPS) in industrial environments is enabling the productive use of machine learning (ML) algorithms in the manufacturing domain. As ML applications transcend from research to productive use in real-world industrial environments, the question of reliability arises. Since the majority of ML models are trained and evaluated on static datasets, continuous online monitoring of their performance is required to build reliable systems. Furthermore, concept and sensor drift can lead to degrading accuracy of the algorithm over time, thus compromising safety, acceptance and economics if undetected and not properly addressed. In this work, we exemplarily highlight the severity of the issue on a publicly available industrial dataset which was recorded over the course of 36 months and explain possible sources of drift. We assess the robustness of ML algorithms commonly used in manufacturing and show, that the accuracy strongly declines with increasing drift for all tested algorithms. We further investigate how uncertainty estimation may be leveraged for online performance estimation as well as drift detection as a first step towards continually learning applications. The results indicate, that ensemble algorithms like random forests show the least decay of confidence calibration under drift