cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Climate-specific health literacy in health professionals: an exploratory study
Creators: name: Albrecht, Lorenz
name: Reismann, Lydia
name: Leitzmann, Michael
name: Bernardi, Christine
name: von Sommoggy, Julia
name: Weber, Andrea
name: Jochem, Carmen
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: climate-specific health literacy, health professionals, physicians, nurses, climate change
subject: 610 Medizin

description: Background: Health professionals such as physicians and nurses may play an important role in the transformation process towards a healthy, sustainable and climate-sensitive society. However, little is known about their climate-specific health literacy. This study aimed to assess knowledge regarding climate change and its impacts on health and climate-specific health literacy in health professionals.

Methods: In July/August 2022, a cross-sectional, questionnaire-based study was carried out at the University Hospital Regensburg, Germany, to assess climate-specific health literacy in nurses and physicians from various clinical specialties. Descriptive and exploratory statistical analyses were performed.

Results: The study population consisted of 142 participants (57.7% women; response rate: 24,7%). Most participants (93%) considered climate change to be highly relevant. However, only 12% of respondents stated to be very well informed regarding the general consequences of climate change. Although 57% of all participants had never mentioned climate change in relation to health to their patients, participants with higher levels of knowledge regarding the effects of climate change were more likely to mention it compared to those with lower levels of knowledge. The most frequently stated obstacle to integrate the topic of climate change in clinical work was lack of time during work (79%), not enough information (42%) and lacking materials (39%). Differences between health professions were apparent.

Conclusion: The results of our survey suggest that the current state of climate-specific health literacy differs between different groups of health professionals. There is a need to improve health professionals’ levels of climate-specific health literacy and to increase the potential in interprofessional cooperation regarding planetary health.
Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review
Creators: name: Knoedler, Leonard
name: Knoedler, Samuel
name: Allam, OmaR
name: Remy, KatyA
name: Miragall, Maximilian
name: Safi, Ali-Farid
name: Alfertshofer, Michael
name: Pomahac, Bohdan
name: Kauke-Navarro, Martin
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: vascularized composite allotransplantation, VCA, facial VCA, face transplant, artificial intelligence, AI, machine learning, deep learning
subject: 610 Medizin

description: Facial vascularized composite allotransplantation (FVCA) is an emerging field of reconstructive surgery that represents a dogmatic shift in the surgical treatment of patients with severe facial disfigurements. While conventional reconstructive strategies were previously considered the goldstandard for patients with devastating facial trauma, FVCA has demonstrated promising short- and long-term outcomes. Yet, there remain several obstacles that complicate the integration of FVCA procedures into the standard workflow for facial trauma patients. Artificial intelligence (AI) has been shown to provide targeted and resource-effective solutions for persisting clinical challenges in various specialties. However, there is a paucity of studies elucidating the combination of FVCA and AI to overcome such hurdles. Here, we delineate the application possibilities of AI in the field of FVCA and discuss the use of AI technology for FVCA outcome simulation, diagnosis and prediction of rejection episodes, and malignancy screening. This line of research may serve as a fundament for future studies linking these two revolutionary biotechnologies.
The Important Role of Protein Kinases in the p53 Sestrin Signaling Pathway
Creators: name: Gülow, Karsten
name: Tümen, Deniz
name: Kunst, Claudia
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: p53; Sestrins; stress response; mTORC; nuclear factor erythroid 2-related factor 2 (Nrf2); mitophagy; autophagy
subject: 610 Medizin

description: p53, a crucial tumor suppressor and transcription factor, plays a central role in the maintenance of genomic stability and the orchestration of cellular responses such as apoptosis, cell cycle arrest, and DNA repair in the face of various stresses. Sestrins, a group of evolutionarily conserved proteins, serve as pivotal mediators connecting p53 to kinase-regulated anti-stress responses, with Sestrin 2 being the most extensively studied member of this protein family. These responses involve the downregulation of cell proliferation, adaptation to shifts in nutrient availability, enhancement of antioxidant defenses, promotion of autophagy/mitophagy, and the clearing of misfolded proteins. Inhibition of the mTORC1 complex by Sestrins reduces cellular proliferation, while Sestrin-dependent activation of AMP-activated kinase (AMPK) and mTORC2 supports metabolic adaptation. Furthermore, Sestrin-induced AMPK and Unc-51-like protein kinase 1 (ULK1) activation regulates autophagy/mitophagy, facilitating the removal of damaged organelles. Moreover, AMPK and ULK1 are involved in adaptation to changing metabolic conditions. ULK1 stabilizes nuclear factor erythroid 2-related factor 2 (Nrf2), thereby activating antioxidative defenses. An understanding of the intricate network involving p53, Sestrins, and kinases holds significant potential for targeted therapeutic interventions, particularly in pathologies like cancer, where the regulatory pathways governed by p53 are often disrupted.
Eligmodontia F. Cuvier 1837
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eligmodontia

description: Eligmodontia F. Cuvier 1837
Eligmodontia F. Cuvier 1837, Ann. Sci. Nat. (Paris), ser. 2, 7: 169.
Type Species: Eligmodontia typus F. Cuvier 1837
Synonyms: Elimodon Fitzinger 1867; Eligmodon Wagner 1841; Heligmodontia Aggasiz 1846.
Species and subspecies: 4 species:
Species Eligmodontia moreni Thomas 1896
Species Eligmodontia morgani J. A. Allen 1901
Species Eligmodontia puerulus Philippi 1896
Species Eligmodontia typus F. Cuvier 1837
Discussion: Phyllotini. Morphologically similar to Calomys (Hershkovitz, 1962; Williams and Mares, 1978), but cladistic interpretations of morphological and molecular data represent the genus as more highly derived, usually as a basal clade to Phyllotis and various kin depending upon the taxa sampled (Braun, 1993; Engel et al., 1998; Spotorno et al., 2001; Steppan, 1993; Smith and Patton, 1999).
Revised by Hershkovitz (1962), who synonymized all forms as E. typus, but morphological, chromosomal, and distributional evidence supports greater species diversity (e.g., Kelt et al., 1991; Mann, 1978; Mares et al., 1989 b; Osgood, 1943; Zambelli et al., 1992). The thrust of recent revisionary research has overwhelmingly reinforced the latter view (Hillyard et al., 1997; Sikes et al., 1997; Sportorno et al., 1994; Tiranti, 1997) and collectively indicates the number of species as at least four. Others are occasionally listed (Braun, 1993; Díaz and Barquez, 1999; Galliari et al., 1996) or noted as species indeterminate (Mares et al., 1997), a situation that underscores the need for continued revision. Tiranti (1997) viewed the northern (E. moreni, E. puerulus) and southern (E. morgani, E. typus) pairs as sister clades and offered a Plio-Pleistocene biogeographic interpretation to explain their phyletic diversification.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1112, DOI: 10.5281/zenodo.7316535
title: Stability Design of a Slender Column with Curved Longitudinal Stiffeners
Creators: name: Lake, Mark S.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1989

description: This thesis presents the results of a stability design study of a slender column with curved longitudinal stiffeners for large space structure applications. The stiffened column concept is attractive because it allows the buckling load of a slender column to be increased at a fairly low cost in increased mass, and at no change in the column packaged size. Linear stability analyses are performed using a "linked-plate" representation of the stiffeners to determine stiffener local buckling stresses. Results from a set of parametric analyses are used to determine an approximate explicit expression for stiffener local buckling in terms of its geometric parameters. This expression along with other equations governing column stability and mass are assembled into a determinate system describing minimum mass stiffened column design. An iterative solution routine is determined to solve this system and a computer program incorporating this routine is presented. Example design problems are presented which verify the solution accuracy and illustrate the implementation of the solution routine. Also, observations are made which lead to a greatly simplified first iteration design equation relating the percent increase in column mass to the percent increase in column buckling load. From this, generalizations are drawn as to the mass savings offered by the stiffened column concept.
Empirical Application Insights on Industrial Data and Service Aspects of Digital Twin Networks
Creators: name: Becattini, Marco
name: Borsatti, Davide
name: Bujari, Armir
name: Carnevali, Laura
name: Garbugli, Andrea
name: Khachatrian, Hrant
name: Raptis, Theofanis P.
name: Tarchi, Daniele
Publisher: name: arXiv
Year: 2024
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Emerging Technologies (cs.ET)
subject: FOS: Computer and information sciences

description: Digital twin networks (DTNs) serve as an emerging facilitator in the industrial networking sector, enabling the management of new classes of services, which require tailored support for improved resource utilization, low latencies and accurate data fidelity. In this paper, we explore the intersection between theoretical recommendations and practical implications of applying DTNs to industrial networked environments, sharing empirical findings and lessons learned from our ongoing work. To this end, we first provide experimental examples from selected aspects of data representations and fidelity, mixed-criticality workload support, and application-driven services. Then, we introduce an architectural framework for DTNs, exposing a more practical extension of existing standards; notably the ITU-T Y.3090 (2022) recommendation. Specifically, we explore and discuss the dual nature of DTNs, meant as a digital twin of the network and a network of digital twins, allowing the co-existence of both paradigms.
description: Funding: (i) European Union under the Italian National Recovery and Resilience Plan (NRRP) of NextGenerationEU, partnership on "Telecommunications of the Future" PE00000001 - program "RESTART", (ii) RA Science Committee grant No. 22rl-052
Eligmodontia moreni Thomas 1896
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eligmodontia
Eligmodontia moreni

description: Eligmodontia moreni Thomas 1896
Eligmodontia moreni Thomas 1896, Ann. Mag. Nat. Hist., ser. 6, 18: 307.
Type Locality: Argentina, La Rioja Prov., Chilecito, 1200 m.
Vernacular Names: Monte Laucha.
Distribution: Atlantic-facing Andean slopes at intermediate elevations, NW Argentina (Salta to Neuquén Prov.); limits poorly documented.
Conservation: IUCN – Lower Risk (lc).
Discussion: Mares et al. (1981 b, 1989 b) noted the morphological, distributional, and ecological distinction of E. moreni and E. puerulus in Salta Prov., Argentina, and Spotorno et al. (1994) substantiated their pronounced karyotypic divergence (2n = 34 versus 2n = 50, respectively).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1113, DOI: 10.5281/zenodo.7316535
Prometopa Schellenberg 1926
Creators: name: Krapp-Schickel, Traudl
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Stenothoidae
Prometopa

description: Genus Prometopa Schellenberg, 1926
Type species: P. tuberculata Schellenberg, 1926
There are currently three included species: P. dorsoundata Bushueva, 1988; P. edentata Rauschert, 1990; P tuberculata Schellenberg, 1926.
Diagnostic characters
A1 with (P. edentata, P. tuberculata) or without (P. dorsoundata, P. cedrici) nasiform process on art. 1. Acc. flag. vestigial. Md palp with 3 arts. Mx1 palp with often not clearly visible articulation between first and second art. Mx2 IP ordinary. Mxp IP well separated. Gn1, 2 different from each other in size and shape, Gn1 small, propodus and carpus long and narrow; Gn2 enlarged, palm oblique, carpus short, lobed. P5 with basis rectolinear, P6, 7 basis rounded. Peraeonites dorsally elevated, peraeonite 4 slightly elongated. Pleonites 2, 3 with dorsal process, pleonites 4-6 free. Telson ordinary, flat.
description: Published as part of Krapp-Schickel, Traudl, 2011, New Antarctic stenothoids sensu lato (Amphipoda, Crustacea), pp. 1-17 in European Journal of Taxonomy 2 on page 3, DOI: 10.5852/ejt.2011.2, http://zenodo.org/record/841661
Zorotypus hubbardi Caudell 1918
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Zoraptera
Zorotypidae
Zorotypus
Zorotypus hubbardi

description: Zorotypus hubbardi
“Hubbard’s angel insect”
Figure 42 (lateral, dorsal)
Several Z. hubbardi specimens were collected from Florida. Unlike the other taxa, where specimens were frozen alive, these specimens died during transport and were frozen upon arrival. Likely due to their untimely demise, tracheae suffered from fluid infilling before scanning, resulting in obscured morphology. Several specimens were scanned, and the best example was chosen for inclusion here. Zoraptera are an excellent candidate for further micro-CT study of better-preserved specimens.
DESCRIPTION: HEAD: H-DCT and H-VCT in close contact, proceeding anteriad. H-Ant off H-DCT, no other head tracheae visible in this scan.
THORAX: T2-S with several branches visible on specimen right side but only two determinable: T2-VB and T2-CT. T2-VB ventrad; T2-VC present. T3-S visible with T3-DLT extending dorsad and posteriorly to link with A1-S. Other thoracic tracheae partial, determined from examining volume cross sections to establish position in the body.
ABDOMEN: A1..7-S discernible.
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
Crocidium immaculatum Bezzi 1922
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Crocidium
Crocidium immaculatum

description: Crocidium immaculatum Bezzi, 1922
29. Crocidium immaculatum 1ɗ1Ψ South Africa (Eastern Cape): Willowmore, 10.xi.1906 (H. Brauns). MS page 27.
Bezzi, 1922: 77 – diagnosis; specimens in HNHM.
Hesse, 1938: 807 – description as C. karooanum Hesse, n. sp. SYN. NOV. Evenhuis & Greathead, 1999: 216 – listed (incorrectly) a holotype in HNHM (destroyed).
Types: The two syntypes in HNHM were destroyed in 1956. No other syntypes have been found. It would be appropriate to designate one of the specimens in SAMC collected at Willowmore by Dr Brauns as lectotype when the SAMC collection is examined.
Remarks: Crocidium immaculatum was not recognised by Hesse (1938, 1963) or Lamas et al. (2003) but was tentatively identified from Namibia by Greathead (2000). However, Hesse (1938) described a species, C. karooanum, from numerous specimens, including some collected by Dr Brauns at Willowmore, which he considered may prove to be the same as C. immaculatum. However, his description and keys specify the presence of two feint but distinct darker spot­like infuscations on the apical veins of the basal cells, which does not accord with Bezzi’s specific name ‘ immaculatum ’. However, Bezzi’s manuscript description is equally equivocal as he wrote that the wings are ‘prorsus immaculatae’ but goes on to specify ‘nervis transversis nubecula quadrum furca vix cinctis’. Thus, his specimens did have clouds on the wings. The key in Lamas et al. (2003) placed C. karooanum in the group with unspotted wings. However, the specimens seen by them have been reexamined and do have clouds on the wings but these were not considered to constitute spots (C.E. Lamas, pers. comm.). Therefore, as the descriptions of Hesse and Bezzi coincide, it is concluded that C. karooanum Hesse is a junior synonym of C. immaculatum Bezzi. SYN. NOV.
So defined, C. immaculatum is a widespread species of the Nama­karoo biome of South Africa and Namibia, recognised by its small size (3–6 mm) pale whitish or yellowish vestiture and at most only feint clouds on the apical veins of the basal cells.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on pages 25-26, DOI: 10.5281/zenodo.158466
Principles and Standards for Designing and Managing Integrable and Interoperable Transformed Health Ecosystems
Creators: name: Blobel, Bernd
name: Ruotsalainen, Pekka
name: Oemig, Frank
name: Giacomini, Mauro
name: Sottile, Pier Angelo
name: Endsleff, Frederik
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 5P medicine; ecosystem; system architecture; knowledge representation; knowledge management; modeling; integration; interoperability
subject: 610 Medizin

description: The advancement of sciences and technologies, economic challenges, increasing expectations, and consumerism result in a radical transformation of health and social care around the globe, characterized by foundational organizational, methodological, and technological paradigm changes. The transformation of the health and social care ecosystems aims at ubiquitously providing personalized, preventive, predictive, participative precision (5P) medicine, considering and understanding the individual’s health status in a comprehensive context from the elementary particle up to society. For designing and implementing such advanced ecosystems, an understanding and correct representation of the structure, function, and relations of their components is inevitable, thereby including the perspectives, principles, and methodologies of all included disciplines. To guarantee consistent and conformant processes and outcomes, the specifications and principles must be based on international standards. A core standard for representing transformed health ecosystems and managing the integration and interoperability of systems, components, specifications, and artifacts is ISO 23903:2021, therefore playing a central role in this publication. Consequently, ISO/TC 215 and CEN/TC 251, both representing the international standardization on health informatics, declared the deployment of ISO 23903:2021 mandatory for all their projects and standards addressing more than one domain. The paper summarizes and concludes the first author’s leading engagement in the evolution of pHealth in Europe and beyond over the last 15 years, discussing the concepts, principles, and standards for designing, implementing, and managing 5P medicine ecosystems. It not only introduces the theoretical foundations of the approach but also exemplifies its deployment in practical projects and solutions regarding interoperability and integration in multi-domain ecosystems. The presented approach enables comprehensive and consistent integration of and interoperability between domains, systems, related actors, specifications, standards, and solutions. That way, it should help overcome the problems and limitations of data-centric approaches, which still dominate projects and products nowadays, and replace them with knowledge-centric, comprehensive, and consistent ones.
Association of Coronary Collaterals and Myocardial Salvage Measured by Serial Cardiac Magnetic Resonance Imaging after Acute Myocardial Infarction
Creators: name: Pec, Jan
name: Buchner, Stefan
name: Wester, Michael
name: Debl, Kurt
name: Hamer, Okka W.
name: Poschenrieder, Florian
name: Maier, Lars S.
name: Arzt, Michael
name: Stadler, Stefan
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: myocardial salvage index; coronary collaterals; myocardial infarction; magnetic resonance imaging
subject: 610 Medizin

description: Background: Coronary collateral flow in angiography has been linked with lower mortality
rates in patients with coronary artery disease. However, the relevance of the underlying mechanism
is sparse. Therefore, we tested the hypothesis that in patients with acute myocardial infarction
(AMI), relevant coronary collateral flow is associated with more salvaged myocardium and lower
risk of developing heart failure. Methods and Results: Patients with first AMI who received a
percutaneous coronary intervention within 24 h after symptom onset were classified visually by
assigning a Cohen–Rentrop Score (CRS) ranging between 0 (no collaterals) and 3 (complete retrograde
filling of the occluded vessel). All 36 patients included in the analysis underwent cardiac magnetic
resonance examination within 3 to 5 days after myocardial infarction and after 12 weeks. Patients
with relevant collateral flow (CRS 2–3) to the infarct-related artery had significantly smaller final
infarct size compared to those without (7 � 4% vs. 20 � 12%, p < 0.001). In addition, both groups
showed improvement in left ventricular ejection fraction early after AMI, whereas the recovery
was greater in CRS 2–3 (+8 � 5% vs. +3 � 5%, p = 0.015). Conclusion: In patients with first AMI,
relevant collateral flow to the infarct-related artery was associated with more salvaged myocardium
at 12 weeks, translating into greater improvement of systolic left ventricular function. The protective
effect of coronary collaterals and the variance of infarct location should be further investigated in
larger studies.
Ostraca from Sabratha: Tripolitanian Museum, Regio VI, is. 12, vano 34
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 9
description: Photos, transcription and annotations ("non identifié").
description: Source: 4MAR_15_2.7-7-10
description: Coverage: Sabratha
description: created: n. d.
Anterior Open Bite Malocclusion: From Clinical Treatment Strategies towards the Dissection of the Genetic Bases of the Disease Using Human and Collaborative Cross Mice Cohorts
Creators: name: Lone, Iqbal M.
name: Zohud, Osayd
name: Midlej, Kareem
name: Paddenberg, Eva
name: Krohn, Sebastian
name: Kirschneck, Christian
name: Proff, Peter
name: Watted, Nezar
name: Iraqi, Fuad A.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: malocclusion; open bite; etiology; treatment; Collaborative Cross mice
subject: 610 Medizin

description: Anterior open bite malocclusion is a complex dental condition characterized by a lack of contact or overlap between the upper and lower front teeth. It can lead to difficulties with speech, chewing, and biting. Its etiology is multifactorial, involving a combination of genetic, environmental, and developmental factors. Genetic studies have identified specific genes and signaling pathways involved in jaw growth, tooth eruption, and dental occlusion that may contribute to open bite development. Understanding the genetic and epigenetic factors contributing to skeletal open bite is crucial for developing effective prevention and treatment strategies. A thorough manual search was undertaken along with searches on PubMed, Scopus, Science Direct, and Web of Science for relevant studies published before June 2022. RCTs (clinical trials) and subsequent observational studies comprised the included studies. Orthodontic treatment is the primary approach for managing open bites, often involving braces, clear aligners, or other orthodontic appliances. In addition to orthodontic interventions, adjuvant therapies such as speech therapy and/or physiotherapy may be necessary. In some cases, surgical interventions may be necessary to correct underlying skeletal issues. Advancements in technology, such as 3D printing and computer-assisted design and manufacturing, have improved treatment precision and efficiency. Genetic research using animal models, such as the Collaborative Cross mouse population, offers insights into the genetic components of open bite and potential therapeutic targets. Identifying the underlying genetic factors and understanding their mechanisms can lead to the development of more precise treatments and preventive strategies for open bite. Here, we propose to perform human research using mouse models to generate debatable results. We anticipate that a genome-wide association study (GWAS) search for significant genes and their modifiers, an epigenetics-wide association study (EWAS), RNA-seq analysis, the integration of GWAS and expression-quantitative trait loci (eQTL), and micro-, small-, and long noncoding RNA analysis in tissues associated with open bite in humans and mice will uncover novel genes and genetic factors influencing this phenotype.
Short-term effects of etifoxine on human gut microbiome in healthy men
Creators: name: Manook, André
name: Baghai, Thomas C.
name: Riebel, Marco
name: Nothdurfter, Caroline
name: Schwarzbach, Jens Volkmar
name: Gessner, André
name: Rupprecht, Rainer
name: Hiergeist, Andreas
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: gut microbiome, etifoxine, neurosteroids, GABA-A transmission, Williams design, 16S rRNA amplicon sequencing, Faecalibacterium duncaniae, Roseburia hominis
subject: 610 Medizin

description: Background: Neurosteroids have recently gained in interest as a treatment strategy for affective disorders. Etifoxine is known for its dual mode of action, one of which is to stimulate endogenous neurosteroid synthesis. The gut microbiome has been studied in affective disorders, but it has not been investigated in the context of human etifoxine or neurosteroid interventions.

Methods: We performed a crossover study with 36 healthy male volunteers who received etifoxine versus alprazolam and placebo in a balanced Williams design. Participants were randomized into six sequences and went through three 5-day treatments followed by wash-out phases of 9 days. Bacterial compositions in stool samples were determined by high-throughput 16S rRNA amplicon sequencing.

Results: Gut microbiome analyses revealed no relevant effects between treatments with respect to alpha and beta diversity. Differential abundance analyses yielded etifoxine treatment as the only effect related to changes in microbial features with reductions of Faecalibacterium duncaniae, Roseburia hominis and Lactobacillus rogosae (i.e., Bacteroides galacturonicus).

Conclusion: Here we report on the first human investigation of the gut microbiome with short-term etifoxine intervention. Differences in diversity and compositional structure of the microbiome were more likely due to between- subject effects rather than medication. However, five-day treatment with etifoxine reduced the abundance of a few bacterial species. These species are currently seen as beneficial components of a healthy intestinal microbiome. This reduction in abundances may be related to elevated endogenous neurosteroids.
Pantostomus Bezzi
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Pantostomus

description: Pantostomus Bezzi
Bezzi (1921b, 1922) introduced Pantostomus as a new genus with a brief diagnosis and designation of P. gibbiventris as genotype but in both publications indicates that it will be fully described in his Hungarian Museum paper. A full description appears in the manuscript in which he compares it to Tomomyza. Hesse (1956) pointed out that Malloch’s (1932) description of the genus was based on a misidentification of the genotype, P. g i b ­ biventris, which he confused with another species from Zimbabwe, later described as P. mallochi Hesse (1956: 69). Hesse went on to provide a full description based on the correctly identified genotype and other species, described as new.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 26, DOI: 10.5281/zenodo.158466
Antatelson walkeri
Creators: name: Krapp-Schickel, Traudl
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Stenothoidae
Antatelson
Antatelson walkeri

description: Antatelson walkeri (Chilton, 1912)
Fig. 7
Thaumatelson walkeri Chilton, 1912: 199-200 pl. 1, figs 11-15; Schellenberg 1931: 113; Thurston 1974: 24-25
Antatelson J.L. Barnard, 1972: 312
Antatelson walkeri Krapp-Schickel, 2006: fig. 4a, b
? Thaumatelson cultricauda K.H. Barnard, 1932: 113, fig. 62
Material examined
Two specimens 2.5 mm. RRS James Clark Ross, cruise JR144 (BIOPEARL I), stn JR 144 SR-EBS-4-E, Shag Rocks, 53°62'S 40°91'W, 11-04-2006, 201- 205 m, gear: epibenthic sledge, 4 Epi-net.
Remarks
Comparing the material here with the illustrations of A. walkeri and A. cultricauda (both described as having 3 mm length) there does not seem any reason for accepting two different species. Gn2 of A. walkeri in Krapp-Schickel (2006 fig. 4) is also less widened than in the original description by Chilton, which would be one of the differentiating characters. In A. claudei sp. nov. (see below) there are similar 'pleats' near the dorsal humps as described for A. cultricauda and it may well be that in some specimens these are more visible than in others. The mandibular palp has three clearly visibile articles and also in other mouthparts there is no difference with the illustrations for A. tuberculatum by Andres (1989: 183 figs 4-8, 184 figs 12-14).
description: Published as part of Krapp-Schickel, Traudl, 2011, New Antarctic stenothoids sensu lato (Amphipoda, Crustacea), pp. 1-17 in European Journal of Taxonomy 2 on page 12, DOI: 10.5852/ejt.2011.2, http://zenodo.org/record/841661
Eligmodontia morgani J. A. Allen 1901
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eligmodontia
Eligmodontia morgani

description: Eligmodontia morgani J. A. Allen 1901
Eligmodontia morgani J. A. Allen 1901, Bull. Am. Mus. Nat. Hist., 14: 409.
Type Locality: Argentina, Santa Cruz Prov., basaltic canyons 50 mi (80 km) SE Lago Buenos Aires.
Vernacular Names: Western Patagonian Laucha.
Distribution: W Patagonian region of S Argentina (C Neuquén and SC Río Negro Provs. south to NW Santa Cruz; see Hillard et al., 1997:Fig. 2) and adjacent Chile.
Conservation: IUCN – Lower Risk (lc).
Discussion: This species epithet was used by Kelt et al. (1991) for the 2n = 32 chromosomal form as compared with 2n = 44 in E. typus proper; the same contrast holds for other populations in sympatry or parapatry in SC Argentina (Tiranti, 1997; Zambelli et al., 1992). Multivariate analysis of craniodental variables underscores the strong morphological divergence of specimens with known karyotype and cytochrome b haplotype (Hillard et al., 1997; Sikes et al., 1997). Historical biogeography with regard to E. typus discussed by Hillard et al. (1997), who elaborated upon the complementarity of their present-day distributions to biotic provinces within Patagonia.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1113, DOI: 10.5281/zenodo.7316535
Pantostomus gibbiventris Bezzi 1921
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Pantostomus
Pantostomus gibbiventris

description: Pantostomus gibbiventris Bezzi, 1921
(Fig. 13)
43 Pantostomus gibbiventris 1ɗ1Ψ South Africa (Eastern Cape): Willowmore, 20.xi.1906 (H. Brauns). MS page 55.
Bezzi, 1921b: 474 – diagnosis based on ‘some specimens from Willowmore (Cape), December and January, Dr H. Brauns’ to be fully described in his forthcoming paper on the Hungarian Museum material.
Bezzi, 1922: 79 – diagnosis based on ‘exemplaria aliqua ex Willowmore, Octob.–Febr., in Museo Budapestini et in collectione mea’. MSNM has one female syntype from Willowmore 20.xi.1906 (Dr Brauns). The Brauns collection in NMSA has 4ΨΨ collected on 15.xii.1917. One of these bears Bezzi’s determination label and another a Brauns determination label. The syntypes in HNHM and MSNM were all collected on the same date in 1906; therefore it is uncertain that these NMSA specimens should be considered as syntypes although Bezzi had seen at least one of them.
Hesse, 1956: 56 – described from topotypic specimens from Brauns’s collection and other specimens in BMNH, TMSA & SAMC (no details of label data).
Evenhuis & Greathead, 1999: 286 – listed an undetermined number of syntypes in SAMC, one syntype in DEI, and one syntype in ZMHB.
Types: The two syntypes in HNHM listed in Bezzi’s manuscript were destroyed in 1956. Bezzi (1922) indicated that some specimens existed in HNHM and his own collection. Only the female syntype in MSNM survives. Hesse (1956) stated that a male specimen in Brauns’s collection bears a red label ‘Bez. 1’, which Hesse considered was proof that it was one of the same batch sent to Bezzi. This does not prove that Bezzi had seen the specimen and is equivocal (see also discussion under P. fucatus concerning another label ‘38 Bezzi’). This casts doubt on the statement in Evenhuis & Greathead (1999) that syntypes are to be found in SAMC, DEI and ZMHB. We therefore here designate the female in MSNM as lectotype (Fig. 13).
Remarks: Hesse (1956) provided a full description of this species and described other new species in the genus.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on pages 26-27, DOI: 10.5281/zenodo.158466
MCT4 blockade increases the efficacy of immune checkpoint blockade
Creators: name: Babl, Nathalie
name: Decking, Sonja-Maria
name: Voll, Florian
name: Althammer, Michael
name: Sala-Hojman, Ada
name: Ferretti, Roberta
name: Korf, Clarissa
name: Schmidl, Christian
name: Schmidleithner, Lisa
name: Nerb, Benedikt
name: Matos, Carina
name: Koehl, Gudrun E.
name: Siska, Peter J.
name: Bruss, Christina
name: Kellermeier, Fabian
name: Dettmer, Katja
name: Oefner, Peter J.
name: Wichland, Marvin
name: Ugele, Ines
name: Bohr, Christopher
name: Herr, Wolfgang
name: Ramaswamy, Shivapriya
name: Heinrich, Timo
name: Herhaus, Christian
name: Kreutz, Marina
name: Renner, Kathrin
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for the survival of patients with rectal cancer, indicating that single MCT4 blockade might be a promising strategy to overcome glycolysis-related therapy resistance.

Methods To determine whether blockade of MCT4 alone is sufficient to improve the efficacy of immune checkpoint blockade (ICB) therapy, we examined the effects of the selective MCT1 inhibitor AZD3965 and a novel MCT4 inhibitor in a colorectal carcinoma (CRC) tumor spheroid model co-cultured with blood leukocytes in vitro and the MC38 murine CRC model in vivo in combination with an antibody against programmed cell death ligand-1(PD-L1).

Results Inhibition of MCT4 was sufficient to reduce lactate efflux in three-dimensional (3D) CRC spheroids but not in two-dimensional cell-cultures. Co-administration of the MCT4 inhibitor and ICB augmented immune cell infiltration, T-cell function and decreased CRC spheroid viability in a 3D co-culture model of human CRC spheroids with blood leukocytes. Accordingly, combination of MCT4 and ICB increased intratumoral pH, improved leukocyte infiltration and T-cell activation, delayed tumor growth, and prolonged survival in vivo. MCT1 inhibition exerted no further beneficial impact.

Conclusions These findings demonstrate that single MCT4 inhibition represents a novel therapeutic approach to reverse lactic-acid driven immunosuppression and might be suitable to improve ICB efficacy.
Face the Future—Artificial Intelligence in Oral and Maxillofacial Surgery
Creators: name: Miragall, Maximilian F.
name: Knoedler, Samuel
name: Kauke-Navarro, Martin
name: Saadoun, Rakan
name: Grabenhorst, Alex
name: Grill, Florian D.
name: Ritschl, Lucas M.
name: Fichter, Andreas M.
name: Safi, Ali-Farid
name: Knoedler, Leonard
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: oral and maxillofacial surgery; oral surgery; maxillofacial surgery; OMFS; artificial intelligence; AI; deep learning; machine learning
subject: 610 Medizin

description: Artificial intelligence (AI) has emerged as a versatile health-technology tool revolutionizing medical services through the implementation of predictive, preventative, individualized, and participatory approaches. AI encompasses different computational concepts such as machine learning, deep learning techniques, and neural networks. AI also presents a broad platform for improving preoperative planning, intraoperative workflow, and postoperative patient outcomes in the field of oral and maxillofacial surgery (OMFS). The purpose of this review is to present a comprehensive summary of the existing scientific knowledge. The authors thoroughly reviewed English-language PubMed/MEDLINE and Embase papers from their establishment to 1 December 2022. The search terms were (1) “OMFS” OR “oral and maxillofacial” OR “oral and maxillofacial surgery” OR “oral surgery” AND (2) “AI” OR “artificial intelligence”. The search format was tailored to each database’s syntax. To find pertinent material, each retrieved article and systematic review’s reference list was thoroughly examined. According to the literature, AI is already being used in certain areas of OMFS, such as radiographic image quality improvement, diagnosis of cysts and tumors, and localization of cephalometric landmarks. Through additional research, it may be possible to provide practitioners in numerous disciplines with additional assistance to enhance preoperative planning, intraoperative screening, and postoperative monitoring. Overall, AI carries promising potential to advance the field of OMFS and generate novel solution possibilities for persisting clinical challenges. Herein, this review provides a comprehensive summary of AI in OMFS and sheds light on future research efforts. Further, the advanced analysis of complex medical imaging data can support surgeons in preoperative assessments, virtual surgical simulations, and individualized treatment strategies. AI also assists surgeons during intraoperative decision-making by offering immediate feedback and guidance to enhance surgical accuracy and reduce complication rates, for instance by predicting the risk of bleeding.
Studies on P.Louvre inv. E 7113
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 19
description: Drawing, transcription, bibliography and photos. - P. COLLART, Glossaire Latin-Grec inédit (P. Th. Reinach inv. 2069), in Mélanges de Philologie, de Littérature et d'Histoire anciennes offerts à Alfred Ernout, Paris 1940, 61-74.
description: Source: 4MAR_19_3.1-22
description: created: n. d.
Long-Term Outcome and Complications of IOL-Exchange
Creators: name: Märker, David
name: Radeck, Viola
name: Barth, Teresa
name: Helbig, Horst
name: Scherer, Nicolas
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: intraocular lens (IOL) exchange, complications, IOL opacification, treatment of complications
subject: 610 Medizin

description: Purpose: To describe the long-term outcome after intraocular lens (IOL) exchange for IOL-opacification with a focus on any
occurring complications.
Patients and Methods: Patients with an IOL exchange for opacified IOLs (Lentis LS-502-1) were identified. Medical records and
information from the treating ophthalmologists were reviewed. Visual outcomes and any occurring complications after the IOL
exchange were analyzed.
Results: IOL exchange was performed in 48 eyes of 46 patients and significantly improved best-corrected distance visual acuity from
0.42 ± 0.32 logMar (mean ± SD) in opacified lenses to 0.25 ± 0.28 logMar after IOL exchange. Nine of the 48 eyes (19%) underwent
11 further surgical procedures for complications due to four indications: IOL dislocation (n = 2, 4%), retinal detachment (RD) (n = 6,
12%), epiretinal membrane (n = 2, 4%), and pupillary block (n = 1, 2%). Three eyes (6%) developed a temporarily elevated intraocular
pressure. Temporary postoperative cystoid macular edema was found in 2 eyes (4%).
Conclusion: IOL exchange can restore vision owing to IOL opacification in most cases. Nonetheless, IOL exchange is not an easy or
risk-free procedure. This may lead to sight-threatening complications, even in eyes without predisposing ocular comorbidities.
Hindfoot and Foot Arch Reconstruction by Atypical Subtalar Arthrodesis and Achilles Tendon Lengthening for a Severe Comminuted Calcaneal Fracture: A Case Report
Creators: name: Straub, Josina
name: Popp, Daniel
name: Walter, Nike
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Hindfoot and foot arch reconstruction, comminuted calcaneal fracture, atypical subtalar arthrodesis
subject: 610 Medizin

description: Open calcaneus fractures are rare but severe injuries. Highenergy
trauma often causes significant soft tissue and bone
damage, posing extraordinary challenges for treatment.3
The rates of complications associated with treatment are
high, including malunion, nonunion, and fracture-related
infections.5 These complications are associated with an
amputation rate of the lower limb of 8%.2 Even if amputation
is avoided and treatment and complication management
are successful, the patient’s quality of life is
compromised, similar to those suffering from bone infections
in the long bones. Apart from compromised soft tissue,
bone defects present the main obstacle to successful
treatment. Anatomical bone reconstruction becomes
difficult, if not impossible, in cases of severe compound
fractures. Open fractures necessitate thorough surgical
debridement to prevent infection, which may result in significant
bone defects requiring bone reconstruction.3,4
Given the immense challenges of surgical treatment following
high-energy injuries, where bone transplantation and
extensive osteosynthesis offer limited promise, we present a
case illustrating an atypical subtalar arthrodesis and hindfoot
reconstruction in a patient with a Gustilo type IIIa°
comminuted calcaneus fracture.
Tomomyza Wiedemann
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Tomomyza

description: Tomomyza Wiedemann
Bezzi (1922) noted that European species referred by authors to Tomomyza are in fact species of Stomylomyia Bigot and that true Tomomyza spp. are all southern African. Bezzi’s manuscript contains a note on the genus setting out the differences between the two genera. He then wrote a full description of Tomomyza and appended a key to species, which was published in Bezzi (1922). Hesse (1956), noting that no comprehensive description of the genus had been published hitherto, provided a fully illustrated description.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 27, DOI: 10.5281/zenodo.158466
Eligmodontia puerulus Philippi 1896
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Eligmodontia
Eligmodontia puerulus

description: Eligmodontia puerulus Philippi 1896
Eligmodontia puerulus Philippi 1896, Anal. Mus. Nac. Chile, Zool. Ent., 13a: 20.
Type Locality: Chile, Antofagasta Prov., San Pedro de Atacama, 3223 m.
Vernacular Names: Altiplano Laucha.
Synonyms: Eligmodontia hirtipes (Thomas 1902); Eligmodontia jacunda Thomas 1919; Eligmodontia marica Thomas 1918; Eligmodontia tarapacensis Mann 1945.
Distribution: Altiplano, usually above 3000 m, of extreme S Perú, through NE Chile and WC Bolivia, to NW Argentina.
Conservation: IUCN – Lower Risk (lc).
Discussion: Reduced to a subspecies of E. typus by Hershkovitz (1962), but morphological (Mann, 1978; Osgood, 1943) and karyotypic (Kelt et al., 1991; Ortells et al., 1989; Spotorno et al., 1994) data sustain the specific recognition of E. puerulus. Further systematic review is required: e.g., Braun (1993) and Díaz and Barquez (1999) viewed hirtipes as a separate species but Anderson (1997) did not; and Galliari et al. (1996) and Mares et al. (1997) listed marica as distinct.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1113, DOI: 10.5281/zenodo.7316535