cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Research Project Summary: Evaluation of Chemical and Physical Characteristics of Water Treatment Residuals Before and After a Freeze-Thaw Cycle
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1994

description: The effects of natural freeze/thawing on the chemical and physical characteristics of eight New Jersey water treatment residuals were investigated in relation to trace metal leaching. Field and laboratory studies indicate that leaching of metals from residuals which have undergone a freeze/thaw cycle is considerably less than raw residuals. Furthermore, freeze-thawed residuals mixed with New Jersey soils leached metals less than raw residuals mixed with soils. The freeze/thaw residuals-soil mixtures, in most cases, exhibited leaching characteristics similar to those of the soils alone.
Hicksonella princeps Nutting 1910
Creators: name: Ramvilas, Ghosh
name: Alderslade, Philip
name: Ranjeet, Kutty
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Gorgoniidae
Hicksonella
Hicksonella princeps

description: Hicksonella princeps Nutting, 1910
Hicksonella princeps Nutting, 1910a: 15, pl. 3, fig. 1, 1a; pl. 4, fig. 10 (Banda); Alderslade 1986; 93, fig. 6 (Great Barrier Reef); Grasshoff 1999:19 (New Caledonia).
Opinion: There is not enough evidence that this species occurs in the region.
Justification:
These Indian records seem to be either invalid or unconfirmable: Kumar et al. 2014a: 60, pl. 27, fig. A–E (Guitor Island); Fernando et al. 2017: 218, pl. 100, fig. A–E (Guitor Island).
Literature analysis: The descriptions given by Kumar et al. (2014a) and Fernando et al. (2017) are identical but the sclerites that are illustrated are quite different from those of H. princeps as figured by Alderslade (1986: fig. 6). In the latter figure, the warts on the clubs and the short, slender spindles are spiny, and on the spindles, there are three of these warts in each of two conspicuous, opposed, median girdles. Sclerites like these are also characteristic of Rumphella aggregata (Nutting, 1910) (see Bayer 1955: fig. 2a). None of the spindles figured in the Indian papers are of this form, and the second sclerite from the left of the “subsurface” sclerites, an oval spindle with numerous girdles of rounded warts, has not been reported for any species of Hicksonella.
Kumar et al. (2015) just listed the species and provided an image of the specimen from the 2014 and 2017 papers above. This species has only been reported from Indonesia, New Caledonia and Australia.
description: Published as part of Ramvilas, Ghosh, Alderslade, Philip & Ranjeet, Kutty, 2023, The taxonomy of Indian gorgonians: an assessment of the descriptive records of gorgonians (Anthozoa: Octocorallia: Alcyonacea) recorded as occurring in the territorial waters of India, along with neighbouring regions and the Andaman and Nicobar Islands, and the highlighting of perceived unethical practice, pp. 1-124 in Zootaxa 5236 (1) on page 75, DOI: 10.11646/zootaxa.5236.1.1, http://zenodo.org/record/7639327
Research Project Summary: Microbial Indicators of Human and Non-human Fecal Contamination of Coastal Waters and Shellfish
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1994

description: The sanitary quality of New Jersey coastal waters is determined in part by measuring the levels of certain intestinally-derived (enteric) bacteria.  Although such tests are very useful in assessing water quality, they are limited in that they cannot distinguish between animal-derived and human-derived pollution and they may not accurately predict the presence of pathogenic viruses.  The objective of this study was to examine whether or not the presence of F+ RNA coliphage (FRNA phage), viruses which infect enteric bacteria, more accurately predict the presence of pathogenic human enteric viruses (HEV) in coastal waters and shellfish impacted by defined types of fecal pollution, including point and non-point, human and non-human fecal wastes.  FRNA phage were detected in 76% and 86% of water and shellfish samples, respectively, which were impacted by animal or human fecal pollution.  For a number of reasons, FRNA phage may be a better predictors of the potential presence of HEV in polluted waters and shellfish than the presently used bacteria indicator tests.  Since it is believed that HEV are derived solely from human pollution sources and pose a greater health threat that animal-derived pollution, the finding that FRNA phage may allow the ability to distinguish human from non-human pollution is significant.
Graphene-Based Thermal Interface Materials and Heat Spreaders
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Efficient thermal management – removal of heat from active components of various devices – is currently considered to be one of the most important requirements for further progress in computers, mobile communications and renewable energy technologies. Thermal interface materials (TIMs), which are applied between the heat generating devices and heat spreaders or packaging cases, constitute the main approach for thermal management. The thermal conductivity of commercially available TIMs is on the order of 1 – 5 W/mK at room temperature. The PI of the project discovered that graphene – an atomic plane of carbon atoms – reveals extremely high thermal conductivity. The prior research conducted in the PI’s Nano-Device Laboratory indicated that addition of the liquid-phase exfoliated graphene to TIMs can enhance their heat conduction properties by more than an order-of-magnitude. The increased thermal conductivity of TIMs can lead to major breakthroughs in several industries. However, TIMs have to be functionalized for applications with the specific substrates and surfaces. The proposed project will aim at investigation of graphene-based TIMs and graphene heat spreaders inserted between different pairs of substrates and surfaces, e.g. semiconductor wafer and metal plate, which are of interest for a given application. Specifically, the PI group will carry out measurements of thermal resistance of the substrate-TIM-surface fixtures with the goal to optimize the TIM’s viscosity, bond-line thickness, and other parameters. The data to be collected in this research is crucial for the graphene-based TIM commercialization. The fundamental study of heat conduction in graphene conducted in the PI’s laboratory was funded by the US government. Successful commercialization of the UC intellectual property pertinent to the graphene TIMs requires additional funding. It is expected that with the UC support the proposed activities will lead to commercialization of the innovation within one year owing to the strong interest from industry and potential high impact. Increasing the thermal conductivity of TIMs from 5 W/mK to ~25 – 30 W/mK will allow one to increase the clock speed of computer chips, increase the efficiency of the photovoltaic solar cells, and improve reliability of mobile communication devices. The project is expected to make a major impact on California’s economy via Silicon Valley’s companies and growing number of photovoltaic energy applications.
A Guide to Implementation of API 653 Tank Inspection, Repair, Alteration and Reconstruction
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1999

description: This guide serves as an overview & quick reference to the use of American Petroleum Institute Standard 653, (API 653) Tank Inspection, Repair, Alteration and Reconstruction, to show compliance with N.J.A.C.7:1E-2.2(a)4. and is not intended to replace the API 653 document. The facility must follow the most recent edition of API 653 issued by the American Petroleum Institute. Only carbon and low alloy steel storage tanks built to API 650 standard are covered by this standard. Plastic and fiberglass storage tanks are not addressed by this standard and therefore must follow the integrity testing and internal inspection procedures of N.J.A.C. 7:1E-2.2(a)4, or alternatives approved by the Department.
Next Generation Cutting Tools: Superhard Refractory Borides
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The continuous search for new superhard materials (hardness H>40 GPa) has provided insight into the chemical and structural requirements to achieve high hardness. Diamond is the hardest known single-phase material (H = 70-110 GPa) and is predominantly used for applications where extreme hardness is a prerequisite, such as cutting tools, forming dies and wear-resistant coatings. In addition to polycrystalline diamond (PCD), cubic boron-nitride (c-BN) and tungsten carbide (WC) are currently most commonly used as cutting implements and abrasives in the metal working industries. The shortcomings of traditional cutting tool materials, however, have introduced challenges to the industries and opportunities for a business based on new materials. For example, diamond is expensive and is not a good choice for the high-speed cutting of ferrous alloys due to its conversion to graphite, leading to destruction of the cutting tool, and possible damage to the work piece. The production of bulk c-BN (H = 45-60 GPa), on the other hand, is costly, requiring high-temperature high-pressure conditions. Among conventional hard tool materials, tungsten carbide is the most favored because of its affordability, practicality and ease of synthesis. This material, however, suffers from low hardness (H = 17-25GPa), leading to a tool’s reduced lifetime. Developing alternatives to replace these materials is thus of great importance. Transition-metal borides have proven to be reliable candidates for superhard applications. Unfortunately, the first superhard refractory borides, which are sufficiently hard for practical applications, contain the expensive platinum group transition metals (Ru, Os or Re). Rhenium diboride (ReB2) is a good example of this family of superhard materials, with a Vickers hardness above 40 GPa, relatively easy synthesis at ambient pressure, high electrical conductivity and excellent elastic properties as we’ve reported over the past several years. Tungsten tetraboride has shown a Vickers hardness of ~43 GPa with a facile synthesis using arc melting. Moreover, we have demonstrated that the addition of rhenium into WB4 can cause an increase in hardness by approximately 15%. Other solid solutions of WB4 are currently being investigated in our lab, along with possible applications.
Guidance for Combining SPCC/FRP and DPCC/DCR Plans
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1997

description: This document has been prepared by the United States Environmental Protection Agency (EPA) Region II and the New Jersey Department of Environmental Protection (NJDEP) to assist facilities who wish to combine their Spill Prevention, Control and Countermeasure (SPCC) plans and/or their Facility Response Plans (FRP) required by the EPA, with their Discharge Prevention, Containment and Countermeasure (DPCC) and Discharge Cleanup and Removal (DCR) plans required by the NJDEP.
HIgh-Throughput Neural Circuit Arrays For CNS Drug Discovery
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project seeks to provide proof of concept for a novel type of nerve cell circuit array to help drive advances in CNS drug discovery. Neurodegenerative disorders of the central nervous system such as Alzheimer's Disease (AD) and Parkinson’s Disease (PD) exact substantial personal cost from patients and socioeconomic cost from society. Despite substantial efforts by biotechnology and pharmaceutical companies, we still lack effective treatments for many CNS illnesses. Recent failures in AD clinical trials have caused commercial entities to pull back on their CNS efforts. Amongst the reasons cited is our current inability to perform high-throughput compound screening on biological models that faithfully reflect early pathology in disease. Recent scientific discoveries have begun to converge on the fact that the initial manifestations of many neurodegenerative diseases can be traced to altered function at individual synapses and neural circuits that mediate communication between nerve cells, cognition, and behavior. While this new insight has attracted much renewed attention on CNS drug discovery, it has also led to the realization that new efficient methods of analyzing neural circuit / synapse function and dysfunction are likely to hold the key to the next generation of effective drug candidates. Under UC proof of concept funding, we propose to demonstrate a new type of micropatterned neural circuit and synapse analysis platform that can be used to investigate synaptic function in a very efficient high-throughput manner suitable for compound library screening. This technology utilizes organic thin film deposition and lithographic processing to convert the random organization of nerve cells and their process observed in current assays into highly ordered arrays in which disease-related aspects of circuit and synaptic function are replicated in high copy number. As an initial demonstration, we will produce a 50-unit array of nigral-striatal circuits, a specific pairing of CNS neurons that have potential application for Parkinson’s Disease. We will then perform array miniaturization into multiplate formats that are the industry standard for compound screening.
Guidance on Discharge Notification, Discharge Response and Discharge Confirmation Reports
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1996

description: The release of a hazardous substance into the waters or onto the lands of the State is defined as a discharge. Releases into waters outside the  jurisdiction of the State are also considered discharges when the potential for damage to State resources exists. Exceptions are releases in compliance with Federal or State Permits.  This document outlines the proper procedure for notifying the DEP when a discharge occurs.  Exceptions to this rule can be made as long as the listed requirements are met.  The DEP must also receive written notification of discharge, the requirements of which are listed.
Leptogorgia lutkeni
Creators: name: Ramvilas, Ghosh
name: Alderslade, Philip
name: Ranjeet, Kutty
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Gorgoniidae
Leptogorgia
Leptogorgia lutkeni

description: Leptogorgia lutkeni (Wright & Studer, 1889)
Lophogorgia lutkeni Wright & Studer, 1889: 150, pl. 30, fig. 1, 1a; pl. 34, fig. 1 (Prince Edward Island).
Leptogorgia lutkeni Bielschowsky 1918: 30; Williams & Lindo 1997: 511–513, figs. 5, 9, 10A; Williams & Vennam 2001: 89–90.
Opinion: This species does not occur in the region.
Justification:
These Indian records seem to be either invalid or unconfirmable: Thomson & Henderson 1906: 264–265 (Andamans); Thomson & Simpson 1909: 264–265 (Andamans); Thomson & Crane 1909: 132–133, fig. 11 (Beyt Island); Thomson & Crane 1909a: 365 (Beyt Island—same material); Fernando 2011: 91–91, pl. 59, fig. 1–1c (Pamban); Fernando et al. 2017: 191–192, pl. 87, fig. 1–1c (Pamban).
Literature analysis: This species was first obtained from Sub-Antarctic waters and was originally placed in Lophogorgia but was later transferred to Leptogorgia by Bielschowski (1918) when revising the genus— Lophogorgia is a junior synonym of Leptogorgia. Bielschowski stated that the Indian and Sri Lankan specimens identified as Leptogorgia l¸tkeni by Thomson & Henderson (1906), Thomson & Simpson (1909) and Thomson & Crane (1909, 1909a) are not this species, which is not surprising as it was first collected off Prince Edward Island at a depth of over 550 m. The specimens these authors described were probably all species of Pseudopterogorgia (Williams & Lindo 1997), and that Thomson & Henderson’s (1905) was probably a new species (Williams & Vennam 2001).
The accounts provided by Fernando (2011) and Fernando et al. (2017) are identical and headed “ Pseudopterogorgia l¸tkeni (Wright & Studer, 1889)”. Their list of synonyms include “ Pseudopterogorgia l¸tkeni Williams & Lindo, 1997 ” and “ Pseudopterogorgia l¸tkeni Williams & Vennam, 2001 ”, when in fact both of these publications recognised the species as a Leptogorgia. As the authors commented, the growth form of their material looks more like that of a species of Lophorgorgia but the sclerites include poorly developed scaphoids, however, the images are very small and the sclerites differences between Leptogorgia and Pseudopterogorgia can be very subtle (Williams & Lindo 1997). It is not until the end of their ‘Remarks’ section that the authors state their specimen is not the same as Lophogorgia l¸tkeni. Rao & Devi (2003) and Venkataraman et al. (2004) just listed the species.
description: Published as part of Ramvilas, Ghosh, Alderslade, Philip & Ranjeet, Kutty, 2023, The taxonomy of Indian gorgonians: an assessment of the descriptive records of gorgonians (Anthozoa: Octocorallia: Alcyonacea) recorded as occurring in the territorial waters of India, along with neighbouring regions and the Andaman and Nicobar Islands, and the highlighting of perceived unethical practice, pp. 1-124 in Zootaxa 5236 (1) on page 76, DOI: 10.11646/zootaxa.5236.1.1, http://zenodo.org/record/7639327
Department of Environmental Protection Annual Report, 1998
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1999

description: This document is comprised of several short reports on key issues within the NJDEP.  The goals for 1998 are set out as well as the actions taken to achieve those goals.  The areas covered are Clean Air, Clean and Plentiful Water, Abundant Open Space,  Healthy Ecosystems, Open and Effective Government, and Safe and Healthy Communities.
A Guide to Employee Training to Conform to DPCC/DCR Regulations N.J.A.C.7:1E-2.12
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1998

description: The purpose of this document is to make available to both the regulating and the regulated community a general guide for training employees at major facilities for compliance with N.J.A.C. 7:1E-2.12.  The document is a compilation of material prepared by Dennis Mahoney of PSE&G for Cook College DPC/DCR training seminars and members of the Bureau of Discharge Prevention Staff.
Combining of "Contingency Plans and Emergency Procedures" required by N.J.A.C. 7:26G-8.1(a), "Discharge Cleanup and Removal Plans" required by N.J.A.C. 7:1E-4.3(a), and "Emergency Response" required by N.J.A.C. 7:31-5
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1999

description: This guidance document was jointly prepared by the Bureau of Hazardous Waste and Transfer Facilities, the Bureau of Discharge Prevention, and the Bureau of Chemical Release Information and Prevention to assist those facilities regulated by the Department of Environmental Protection under N.J.A.C. 7:26G, N.J.A.C. 7:1E, and N.J.A.C. 7:31 respectively, that wish to combine the emergency response plans required by each of the programs, into one overall plan. It is intended to be used as a reference and a guide when combining the above referenced plans  and procedures by presenting to the facilities the conditions that must be met in order to satisfy the requirements of each bureau.
Socioeconomics and Ethnicity Affect Tumor Endocrine Status
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is a fact that women of certain ethnic backgrounds have a greater chance of dying from breast cancer. An African American woman will die of breast cancer more often than a Caucasian woman, regardless of socioeconomic status. Women of Asian descent develop breast cancer at a much lower incidence than other ethnic groups and live longer when afflicted. A major determinant of these differences may lie in receptors for sex hormones like estrogen and progesterone that exist in tumor cells. We know that the distribution of estrogen and progesterone receptors (ER and PR) varies across ethnic groups. The binding of estrogen and progesterone to these ER and PR receptors drives the growth of the tumor. In fact, one of the mainstays of breast cancer treatment is the use of drugs that block the access of estrogen and progesterone to these receptors. Through my proposed project, I will assess the distribution of ER and PR in different ethnic groups in an environment of patients with strictly controlled socioeconomic status. My results will attempt to determine if differences of receptor distribution are indeed related to how long someone with breast cancer will live.

 The hypothesis is that ER and PR isoforms exist in different proportions for different ethnic groups. This discrepancy in ER and PR distribution may account for varying aggressiveness of cancers and at least some of the differences in survival. San Francisco General Hospital (SFGH) provides a study setting that is controlled for socioeconomics, environment and access to care. The 660+ patients who have had their breast surgery at the SFGH Breast Clinic over the past decade are all residents of SF County and of the same socioeconomic status. We have categorized the patients into four ethnic groups: Non-Hispanic Caucasian, African American, Hispanic, and Asian. The Tumor Registry information about these women suggests that in spite of similar stages of breast cancer at diagnosis, outcomes differ between ethnic groups treated at SFGH.A
Leptogorgia thomassini Ramvilas & Alderslade & Ranjeet 2023, new comb.
Creators: name: Ramvilas, Ghosh
name: Alderslade, Philip
name: Ranjeet, Kutty
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Gorgoniidae
Leptogorgia
Leptogorgia thomassini

description: Leptogorgia thomassini (Tixier-Durivault, 1972) new comb.
Lophogorgia thomassini Tixier-Durivault, 1972: 47, fig. 19 (Madagascar).
Psudopterogorgia thomassini (new comb.) Williams & Vennam 2001: 88.
Opinion: There is no evidence that this species occurs in the region.
Justification:
These Indian records seem to be either invalid or unconfirmable: Fernando 2011: 104–105, pl. 63, fig. 2–2c (Uvari); Fernando et al. 2017: 209, pl. 96, fig. 1–1c (Uvari).
Literature analysis: Tixier-Durivault’s description of this taxon as Lophogorgia thomassini is very inadequate. As is often the case with that author’s works the sclerite drawings are extremely poor and do not match the text, and consequently the species is unrecognisable. William & Vennam (2001) interpreted some of the sclerite drawings as indistinct scaphoids, presumably H and I in figure 19, and transferred the species to the genus Pseudopterogorgia. Although these sclerites are not actually curved they are asymmetrical and have larger warts on one side, but it is the side with the greatest, and not the lessor, convexity. It is more likely the original diagnosis was correct, but the name should be Leptogorgia thomassini as Lophogorgia is a synonym of Leptogorgia: there are a number of species of this genus off the east coast of Africa.
The accounts of the Indian material by Fernando (2011) and Fernando et al. (2017) are identical and the specimen described as Psudopterogorgia thomassini actually appears to be a species of Leptogorgia as the colony form is not pinnate and there does not appear to be any scaphoids among the figured sclerites. But, unlike the holotype of the species, their colony does not have branches with a medial groove, the polyps are all around and not biserial, and the spindles have 2–9 whorls of warts and not 2–4. Their specimen appears to be extremely similar to, and perhaps the same as, their Pseudopterogorgia vedalaiensi specimen described in the same two papers.
description: Published as part of Ramvilas, Ghosh, Alderslade, Philip & Ranjeet, Kutty, 2023, The taxonomy of Indian gorgonians: an assessment of the descriptive records of gorgonians (Anthozoa: Octocorallia: Alcyonacea) recorded as occurring in the territorial waters of India, along with neighbouring regions and the Andaman and Nicobar Islands, and the highlighting of perceived unethical practice, pp. 1-124 in Zootaxa 5236 (1) on page 76, DOI: 10.11646/zootaxa.5236.1.1, http://zenodo.org/record/7639327
Structure and Function of the Bax Apoptosis Regulator
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The molecular structures of cancer-related molecules bring insight to their functions, and provide targets for the design of drugs that offer potential approaches to treating tumors. The Bcl2 genes encode a family of proteins that regulate cell survival and cell death in many tissues, including mammary tissue and breast cancer. They are believed to exert their pro- or anti- cell death activities through the transport of salts and biological materials across the membranes of mitochondria. These transport processes are essential for maintaining cell viability, while their de-regulation can lead to cancer.

 Our objective is to understand the relationship between the molecular structures of the membrane-associated Bcl2 proteins, and their activities as transporters in artificial membranes and in cells. The research is designed to test the hypothesis that the transport activity of these proteins is important in regulating cell death in breast cancer. The structures of Bcl2 proteins are essential for understanding their modes of action, and they are the first step towards in the development of structure-based therapeutic drugs to breast cancer. The two principal specific aims are: (1) to determine the structure of the cell death-inducing membrane-associated Bcl2 protein Bax; and (2) to understand its role as a membrane transporter in breast cancer cells.

 The molecular structure of Bax will be determined using magnetic resonance spectroscopy of the protein in artificial membranes. We have already obtained preliminary data that demonstrate experimental feasibility and that give an initial view of the protein architecture. The transport activity of Bax will be characterized in artificial membranes - transport across membranes leads to electrical currents that can be measured and characterized in the laboratory - and in cells - using assays developed by in our laboratory.

 One of the most important research goals for the treatment of cancers is the identification and characterization of new therapeutic targets, and proteins that regulate cell death and membrane transport, like those of the Bcl2 family, represent a very attractive approach. The structure-activity study that we describe is an important step for understanding the biology of both normal breast and breast cancer cells, and the structures of Bcl2 proteins in membranes may provide specific targets for breast cancer drugs: the structures guide the design and screening of drug molecules.
Environmentally Sensitive Areas Guidance Document
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1998

description: This "Guidance on Environmentally Sensitive Areas" is intended for use as a reference and a guide when gathering information to be used in preparing the topographical maps for Discharge Prevention, Containment and Countermeasure (DPCC), and Discharge Cleanup and Removal (DCR) Plans. It gathers in one place all the citations listed in N.J.A.C. 7:1E-1.8, which establishes the definition of environmentally sensitive areas for the purpose of developing the DPCC/DCR plan. The areas described in this document are by no means the only environmentally sensitive areas in New Jersey, but represent those most likely to be adversely affected by the discharge of a hazardous substance. When used in conjunction with N.J.A.C. 7:1, Appendix A, "Mapping and Digital Data Standards", it will prove useful in preparing the topographical maps and the environmentally sensitive areas protection plan that are required as part of the Discharge Cleanup and Removal plan.
Studies of Telomere Capping Dysfunction in Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the earliest changes during the development of breast cancers is the disruption or rearrangement of the genome within a small subset of normal (i.e., non-cancerous) breast cells. Disruption of the genome or loss of genome integrity can cause normal cellular growth to become deregulated. Cells that lose growth control then divide abnormally and can develope eventually into a cancerous tumor. Recently, there has been an accumulation of evidence that proper maintenance of the very ends of chromosomes (called "telomeres") may play an important role in the loss of genome integrity during breast cancer development. The enzyme responsible for synthesizing the specific DNA at the ends of chromosomes, telomerase, is "activated" in almost all breast tumors that have been examined. In addition, mice, which normally do not develop breast cancer, develop breast adenocarcinomas by the artificial creation of a dysfunctional, or non-capped, telomere. Finally, telomere associations or telomere fusions (which cause genome disruptions) have been shown to occur in a model cellular breast cancer system that is widely used and accepted.

 The main specific aims are, first, to use a model cell system for breast cancer to study early stages of cancer progression using microscopic inspection of chromosomes (fluorescence in situ hybridization or FISH). Previous work has suggested a 4-stage progression of breast cancer in this cellular model system that involves senescence (i.e. cell aging), agonescence (escape from cell aging), conditionally immortal, and fully immortal. Our goal is to relate these stages to points at which chromosomal alterations and telomere capping dysfunction occur. The second aim is to follow-up by relating these FISH-detected events with molecular alterations in key temomere-associated proteins, such as Ku, PKCs, Tin2, TRF1 and 2, and Tankyrase. These studies will use antibodies and immunoprecipitation experiments to develop more detailed picture of the molecular associations between these individual telomere proteins. The goal is to develop both a chronological and physical model of how telomere protein complexes are related to stages in breast cell immortalization- the first stage of breast cancer progression.

 Finally, in combination with these aims we will also explore the potential of using a PCR-based approach to detect telomere-associated chromosomal fusions. Since tumors are heterogeneous, it is a challenging problem in clinical pathology to detect advanced and potential malignant disease within a background of mostly normal and pre-neoplastic cells. We are hoping that success in a PCR detection test might lead to a clinical application using small needle biopsies of DCIS or other early stage tumors.
Pseudopterogorgia
Creators: name: Ramvilas, Ghosh
name: Alderslade, Philip
name: Ranjeet, Kutty
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Gorgoniidae
Pseudopterogorgia

description: Genus: Pseudopterogorgia
Preliminary remarks: The identification of specimens of Pseudopterogorgia is problematic because, for example, as in the Ellisellidae, the differences between the sclerites of one species and those of another are generally subtle. Consequently, attempts to recognise different taxa are heavily reliant on very detailed analyses of their traits, most especially the architecture of the sclerites, being clearly presented in species descriptions. Additionally, colony forms often do not greatly differ and are shared by different species, and any descriptions should ideally be based on multiple specimens to try to cope with character differences that may only be due to intraspecific variation.
Of the 26 species reported to occur in the region, only 6 are not authored by Fernando (2011). Unfortunately, these accounts all contain images of masses of sclerites that are all far too small to see any detail, and they are also generally based on only one or several specimens (admittedly unavoidable). Attempts to use these accounts to discriminate between the nominal taxa are further complicated when scales are omitted from the figures and when all of the data required for comparisons are not consistently documented for each taxon. With 20 new species of this genus being erected it is perhaps not surprising that, from what data are available, many of the nominal taxa can probably be synonymised. For example, their specimens of Pseudopterogorgia thomasisini and P. vedalaiensis appear to represent the same species, both have two types of spindles, and there are many obvious similarities within the following groups:
A) Pseudopterogorgia balasbrumanii, P. flexibilis, P. filiformis, P. kotapatnamensis, P. mangalorensis, P. philipi and P. rubra.
B) P. anastomosans, P. australiensis (Ridley, 1884), P. formosa, P. kodiakaraiensis, P. rubrotincta Thomson & Henderson, 1905, and P. williamsi
C) P. mandabamensis, (P. kodiakaraiensis), P, pandianii.
D) P. fredericki Williams & Vennam, 2001, P. undulata
E) P. olivae, (P. rubra).
description: Published as part of Ramvilas, Ghosh, Alderslade, Philip & Ranjeet, Kutty, 2023, The taxonomy of Indian gorgonians: an assessment of the descriptive records of gorgonians (Anthozoa: Octocorallia: Alcyonacea) recorded as occurring in the territorial waters of India, along with neighbouring regions and the Andaman and Nicobar Islands, and the highlighting of perceived unethical practice, pp. 1-124 in Zootaxa 5236 (1) on page 77, DOI: 10.11646/zootaxa.5236.1.1, http://zenodo.org/record/7639327
The Role of BRCA1 in Nucleotide Excision Repair
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Recent strides in breast cancer research have determined that mutations in two genes, BRCA1 and BRCA2, are responsible for 5-10% of all breast cancers. A significant portion of these cancers also harbor a mutation in p53, a tumor suppressor gene mutated in >70% of human cancers. This provides an important clue as to the linkage between the BRCA genes and p53. An important function of p53 is to regulate a type of DNA repair pathway; 'nucleotide excision repair', which corrects DNA damaged from many environmental toxins including cigarette smoke and ultraviolet radiation. However, the failure to correctly repair damaged DNA leads to the accumulation of genetic mutations which is a characteristic of cancer. One way that p53 affects nucleotide excision repair is through regulation of GADD45, a DNA damage response gene. BRCA1 also regulates the GADD45 gene, independent of p53.

 The aim of this project is to understand the role of BRCA1 in the nucleotide excision repair pathway. We plan to develop genetically engineered mouse and human cell lines that either overexpress or lack the expression of the GADD45 or BRCA1 genes. We will then evaluate DNA repair properties in these cell lines after exposure to different DNA damaging agents. Finally, we plan to identify novel genes regulated by BRCA1 in the response to ultraviolet and ionizing radiation by using cDNA microarray technology recently developed at Stanford. The major locus of our work will be to incorporate the information on nucleotide excision repair from other cells into the p53 and BRCA1 context seen in breast cancer, where mutations in these two proteins are facilitators of the disease.

 The planned research is significant because it aims to elucidate the role of the BRCA1 gene in an important DNA repair pathway, whose normal function is critical in preventing cancer. In addition to our interests in the initiation and progression of breast cancer, this research has a cancer treatment aspect, too. Since the cell-killing effects of chemotherapy drugs can be neutralized by breast cancer cells via DNA repair pathways, then our research could lead to the better application of treatment strategies.
Criteria for Choosing a Qualified Specialist to Certify an Environmentally Sensitive Area's Protection Plan Pursuant to N.J.A.C. 7:1E-4.3(a)5
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1998

description: The information contained in this document is intended to provide guidance in choosing qualified individuals to develop and certify environmentally sensitive area's protection plans.  These are the minimum desired qualifications for this position..
Anti-E-Cadherin Apoptosis of Inflammatory Breast Carcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Inflammatory breast cancer is an unusual type of the disease that is characterized by a very high degree of invasion into the blood and lymphatic vessels. We have established the first human model of this form of the disease, a transplantable inflammatory carcinoma xenograft model called MARY-X. This is a human tumor obtained from a patient with inflammatory breast carcinoma, which grows in mice similar to humans. This allows us to study the detailed molecular mechanisms that regulate inflammatory carcinoma. Our specific interest is the invasion of cancer cells into the blood and lymphatic vessels. MARY-X is extremely aggressive in this invasion process, and it even turns the skin of the mouse bright red just like inflammatory cancer does in humans.

 We have been comparing MARY- X with non-inflammatory breast carcinoma cell lines and xenografts for a number of different molecules. A key difference appears to be in a cell adhesion receptor called E-cadherin. MARY-X cells have increased amounts of cell surface E-cadherin. This was surprising because E-cadherin functions in normal breast epithelial cells in the formation of cell-cell junctional complexes. In most breast cancers the amount of E-cadherin decreases, such that is a ‘marker’ for cancer. MARY-X cells usually grow in the form of cell balls or spheroids. We find that treating these cells with E-cadherin antibodies will cause cell disaggregation and cell death (i.e., apoptosis).

 Thus, the focus of the present study is to explore the role of the E-cadherin cell surface receptor in the biology of inflammatory breast carcinoma by studying key processes in our mouse model, MARY-X. We plan to study, first, how E-cadherin attaches to the cell cytoskeleton in these cells. Secondly, we plan to detail the relationship between E-cadherin and apoptotic cell death pathways.

 Inflammatory breast cancer spreads locally via micrometastasis. Our goal is to answer key questions on the cell adhesion properties in this form of breast cancer with the aim of developing approaches to treat this form of the disease.
Research Project Summary: Survey of Surface Source Waters for Giardia and Cryptosporidium and Water Treatment Efficiency Evaluation
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1995

description: Giardia and Cryptosporidium (shortened to "Crypto") parasites are among the leading identified causes of waterborne disease in the United States. Giardia cysts and Crypto oocysts have been identified in many surface waters throughout the country, but the concentrations in most of New Jersey's (NJ) surface waters, many of which are used as source waters for drinking water treatment plants, are unknown. To provide safe drinking water, treatment plants need to remove Giardia and Crypto from untreated water or reduce their concentrations to safe levels. Peak parasite levels, together with adverse water treatment factors, such as low water temperature, determine the maximum risk of human infection. However, parasite testing is not required by law and is not routinely performed by water treatment plants or regulatory personnel because the methods available are difficult, expensive, time-consuming, and have other drawbacks. In this project, 15 sites (. 45% of NJ's surface source waters) were selected to represent the full anticipated range of water quality and potential parasite impact in the state. Each site was sampled 10 times over a one year period at varying turbidity levels (final n=147). Parasites were isolated and partially purified from 100 gallon samples and examined microscopically. Giardia and Crypto were detected in 23% and 20% of the samples at average concentrations of 2.1 cysts/liter (range 0.4-6.3) and 2.0 oocysts/liter (range 0.3 - 9.8), respectively. These concentrations were similar to those found in an earlier national study. No individual location had unusually high parasite concentrations. Parasite levels did not correlate with any other, more easily measured water quality parameter such as turbidity or coliform bacteria. The treatment effectiveness of two of the treatment facilities was monitored on 9 parasite sampling days by measuring particle count reductions and determining disinfectant (chlorine) concentration and contact time (C x t) inactivation values for Giardia. Source water Giardia levels were reduced following treatment to a health risk-based goal of 0.0007 organisms per 100 liters on all but one occasion when pre-disinfection C x t values were included with the post-disinfection values. There is currently insufficient health-risk and "field" disinfection data to perform similar treatment efficiency calculations for Crypto.
Pseudopterogorgia anastomosan Fernando 2011
Creators: name: Ramvilas, Ghosh
name: Alderslade, Philip
name: Ranjeet, Kutty
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Cnidaria
Anthozoa
Alcyonacea
Gorgoniidae
Pseudopterogorgia
Pseudopterogorgia anastomosan

description: Pseudopterogorgia anastomosan Fernando, 2011 (species status uncertain)
Pseudopterogorgia anastomosan Fernando, 2011: 79–80, pl. 53, fig. 1–1c (Tuticorin); Fernando et al. 2017: 173, pl. 79, fig. 1–1d & 79a (Tuticorin).
Opinion: This species does occur in the region but it is probably the same as some of the other Pseudopterogorgia species described by Fernando (2011).
Justification:
Literature analysis: The descriptions of the Indian material by Fernando (2011) and Fernando et al. (2017) are identical and the species is possibly new, but without more detailed descriptions and larger illustrations of the sclerites it would be difficult to recognise and distinguish from some of their other species.
description: Published as part of Ramvilas, Ghosh, Alderslade, Philip & Ranjeet, Kutty, 2023, The taxonomy of Indian gorgonians: an assessment of the descriptive records of gorgonians (Anthozoa: Octocorallia: Alcyonacea) recorded as occurring in the territorial waters of India, along with neighbouring regions and the Andaman and Nicobar Islands, and the highlighting of perceived unethical practice, pp. 1-124 in Zootaxa 5236 (1) on page 77, DOI: 10.11646/zootaxa.5236.1.1, http://zenodo.org/record/7639327
Research Project Summary: A Method for Evaluating Ground-Water-Recharge Areas in New Jersey
Creators: name: No Name Supplied
Publisher: name: New Jersey Department of Environmental Protection
Year: 1993

description: Ground-water recharge is defined as precipitation upon a given area, less those volumes of water which are diverted by surface runoff, evapotranspiration, or by the filling of soil-moisture deficits.  The resulting ground water is vital for aquifer recharge, stream base flow, and wetlands recharge.  Preserving ground-water-recharge areas is vital to protecting ground-water users and ecosystems.  This report summary presents a graphically-based method for evaluating ground-water recharge.  It requires knowledge of an area's soil types, land use and land cover.  Factors based on these characteristics, as well as a climate factor based on the municipality, are provided in the report.
title: The pathologies of the lumbosacral junction
title: Les pathologies de la charnière lombo-sacrée
Creators: name: Hajar Arabi
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2024
Subjects: Charnière lombo-sacrée; Pathologies; Etiologies.

description: The lumbosacral junction (LSJ) is the transitional region between the lumbar spine and the sacrum, corresponding to the space between the fifth lumbar vertebra and the first sacral vertebra. It plays an important role in the biomechanics of the spine. However, it is subject to various conditions, including infectious spondylodiscitis, degenerative pathologies such as disc herniation, discarthrosis, spondylolisthesis, and lumbar synovial cysts. Additionally, it can be affected by diseases such as spondyloarthritis, as well as tumors, whether benign or malignant. Besides acquired causes, malformations such as Bertolotti's syndrome, spina bifida, dural mega cul-de-sac, Tarlov's meningioma, and traumas can also alter the lumbosacral junction.
description: La charnière lombo-sacrée (CLS) est la région de transition entre la colonne lombaire et le sacrum, elle correspond à l’espace situé entre la 5éme vertèbre lombaire et la première vertèbre sacrée. Elle joue un rôle important dans la biomécanique de la colonne vertébrale. Toutefois, elle est sujette à diverses affections, notamment les pathologies dégénératives tels que la hernie discale, la discarthrose, les spondylolisthésis et les kystes synoviaux lombaires. Elle peut être également affectée par la spondylodiscite infectieuse,  au cours des spondyloarthrites, ainsi que par des tumeurs, qu'elles soient bénignes ou malignes. En dehors des causes acquises, des malformations comme le syndrome de Bertolotti, la spina bifida, le méga cul-de-sac dural, le kyste méningé de Tarlov et les traumatismes peuvent également altérer la charnière lombo-sacrée.