cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of ionic strength on the regulation of Na/H exchange and K-Cl cotransport in dog red blood cells
Creators: name: Parker, John C.
name: Minton, Allen P.
name: Dunham, Philip B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: Dog red cell membranes contain two distinct volume-sensitive transporters: swelling-activated K-Cl cotransport and shrinkage- activated Na/H exchange. Cells were prepared with intracellular salt concentration and weight percentage of cell water (%cw) varied independently by transient permeabilization of the cell membrane to cations. The dependence of transporter-mediated Na and K influxes upon %cw and upon extracellular salt concentration (c(ext)) was measured in cells so prepared. It was found that the critical value of %cw at which transporters are activated, called the set point, is similar for the two transporters, and that the set points for the two transporters decrease similarly with increasing extracellular salt concentration. These findings suggest a common mechanism of regulation of these two transporters. Cellular Na, K, and Cl concentrations were measured as functions of %cw and c(ext). Using these data together with data from the literature for other solute concentrations, empirical expressions were developed to describe the dependence of the intracellular concentrations of all significant small molecule electrolytes, and therefore the intracellular ionic strength, upon %cw and c(ext). A mechanistic model for the dependence of the set point of an individual transporter upon intracellular ionic strength is proposed. According to this model, the set point represents a critical extent of association between the transporter and a postulated soluble regulatory protein, called regulator. Model functions are presented for the calculation of the thermodynamic activity of regulator, and hence extent of regulator- transporter association, as a function of total intracellular protein concentration (or %cw) and ionic strength. The experimentally observed dependence of set point %cw on c(ext) are simulated using these functions and the empirical expressions described above, together with reasonable but not uniquely determined values of model parameters.
STRUCTURE ET ADAPTATION D'HALAMMOHYDRA ADHERENS
Creators: name: SWEDMARK, Bertil
name: TEISSIER, Georges
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: Halammohydra adherens is different from the three other species of the same genus by the presence of a special muscle in the aboral cone which permits to the adhesif organ to function as a sucking disk. The species lives in rough sediments, where the species is very stationary, about permanently fixed on a fragment of valves or on a grain of sand. A diagnosis of H. (Skodenhydra) adherens is given.
Single-channel currents from diethylpyrocarbonate-modified NMDA receptors in cultured rat brain cortical neurons
Creators: name: Palloti’a, Barry S.
name: Donnelly, Janet L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: The role of histidine residues in the function of N-methyl-D-aspartate (NMDA)-activated channels was tested with the histidine-modifying reagent diethylpyrocarbonate (DEP) applied to cells and membrane patches from rat brain cortical neurons in culture. Channels in excised outside-out patches that were treated with 3 mM DEP for 15-30 s (pH 6.5) showed an average 3.4-fold potentiation in steady state open probability when exposed to NMDA and glycine. Analysis of the underlying alterations in channel gating revealed no changes in the numbers of kinetic states: distributions of open intervals were fitted with three exponential components, and four components described the shut intervals, in both control and DEP-modified channels. However, the distribution of shut intervals was obviously different after DEP treatment, consistent with the single-channel current record. After modification, the proportion of long shut states was decreased while the time constants were largely unaffected. Burst kinetics reflected these effects with an increase in the average number of openings/burst from 1.5 (control) to 2.2 (DEP), and a decrease in the average interburst interval from 54.1 to 38.2 ms. These effects were most likely due to histidine modification because other reagents (n- acetylimidazole and 2,4,6-trinitrobenzene 1-sulfonic acid) that are specific for residues other than histidine failed to reproduce the effects of DEP, whereas hydroxylamine could restore channel open probability to control levels. In contrast to these effects on channel gating, DEP had no effect on average single-channel conductance or reversal potential under bi-ionic (Na+:Cs+) conditions. Inhibition by zinc was also unaffected by DEP. We propose a channel gating model in which transitions between single- and multi-opening burst modes give rise to the channel activity observed under steady state conditions. When adjusted to account for the effects of DEP, this model suggests that one or more extracellular histidine residues involved in channel gating are associated with a single kinetic state.
A criterion for the Legendrian simplicity of the connected sum
Creators: name: An, Byung Hee
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25

description: In this paper, we provide the necessary and sufficient conditions for the connected sum of knots in $S^3$ to be Legendrian simple.
description: 11 pages, 8 figures
การนำหลักสมคบคิดกันกระทำความผิดมาใช้ในพระราชบัญญัติประกอบรัฐธรรมนูญว่าด้วยการป้องกันและปราบปรามการทุจริต พ.ศ. 2561
Creators: name: เทพนฤทธิ์ พี่พิมาย
name: สุขสมัย สุทธิบดี
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: พระราชบัญญัติประกอบรัฐธรรมนูญว่าด้วยการป้องกันและปราบปรามการทุจริต พ.ศ. 2561
หลักสมคบคิด
ผู้สมคบ
The Organic Act on Anti-Corruption B.E. 2561
Conspiracy
Conspirator

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 326-340
(1852) James Turner
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cases of abnormal hermaphroditism in velvet belly Etmopterus spinax (Chondrichthyes: Etmopteridae) from the southern coast of Portugal
Creators: name: COSTA, Maria Esmeralda
name: BORGES, Teresa Cerveira
name: CAPAPÉ, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The authors described in this note three hermaphroditic specimens of the Velvet belly Etmopterus spinax (Linnaeus, 1758) captured off the southern coast of Portugal (Algarve), during commercial trawl fisheries. The concomitant presence of a pair of claspers and a normal and complete female reproductive system allowed considering these specimens as hermaphrodites. These three specimens are the first cases of hermaphroditism recorded in E. spinax to date and the second reported case of hermaphroditism in chondrichthyan species in Portuguese waters. The authors summarized and comment the different records of hermaphroditism known to date in sharks, pointing out that such a phenomenon is extremely rare within this group.
(1853) Helena Stewart
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Impact of concomitant systemic treatments on toxicity and intracerebral response after stereotactic radiotherapy for brain metastases
Creators: name: Guénolé, Morgan
name: Lucia, François
name: Bourbonne, Vincent
name: Dissaux, Gurvan
name: Reygagne, Emmanuelle
name: Goasduff, Gaëlle
name: Pradier, Olivier
name: Schick, Ulrike
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1: Figure 1. Probability of local control depending on: (A) administration of concomitant immunotherapy (IT) and (B) metastases volume. Figure 2. Probability of freedom from distant brain metastases (FFDBM) depending on (A) Dose prescription modality and (B) Administration of concurrent immunotherapy (IT). Figure 3. Probability of occurrence of radionecrosis (RN) depending on the administration of concurrent immunotherapy (IT).
การเตรียมความพร้อมการรองรับสังคมสูงวัยในระดับตำบลของประเทศไทย
Creators: name: นพวรรณ เลิศผสมสิทธิ์
name: เชาวฤทธิ์ เชาว์แสงรัตน์
name: อำนวย บุญรัตนไมตรี
name: ชัชวาล ทองแสงล้วน
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: ความพร้อม
การรองรับสังคมสูงวัย
ระดับตำบล
Preparation
Supporting an Aging Society
Sub-District Level

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 341-352
Optical Spin Polarization Dynamics in GaSe Nanoslabs
Creators: name: Tang, Yanhao
name: Xie, Wei
name: Mandal, Krishna C.
name: McGuire, John A.
name: Lai, Chih-Wei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report nearly complete preservation of "spin memory" between optical absorption and photoluminescence (PL) in nanometer slabs of GaSe pumped with up to 0.2 eV excess energy. At cryogenic temperatures, the initial degree of circular polarization ($ρ_0$) of PL approaches unity, with the major fraction of the spin polarization decaying with a time constant $>$500 ps in sub-100-nm GaSe nanoslabs. Even at room temperature, $ρ_0$ as large as 0.7 is observed, while pumping 1 eV above the band edge yields $ρ_0$ = 0.15. Angular momentum preservation for both electrons and holes is due to the separation of the non-degenerate conduction and valence bands from other bands. In contrast to valley polarization in atomically thin transition metal dichalcogenides, here optical spin polarization is preserved in nanoslabs of 100 layers or more of GaSe.
description: 6 pages, 5 figures
T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle
Creators: name: Anderson, Kristin
name: Meissner, Gerhard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: In vertebrate skeletal muscle, the voltage-dependent mechanism of rapid sarcoplasmic reticulum (SR) Ca2+ release, commonly referred to as excitation-contraction (EC) coupling, is believed to be mediated by physical interaction between the transverse (T)-tubule voltage-sensing dihydropyridine receptor (DHPR) and the SR ryanodine receptor (RyR)/Ca2+ release channel. In this study, differential T-tubule and SR membrane monovalent ion permeabilities were exploited with the use of an ion-replacement protocol to study T-tubule depolarization-induced SR 45Ca2+ release from rabbit skeletal muscle whole-cell homogenates. Specificity of Ca2+ release was ascertained with the use of the DHPR antagonists D888, nifedipine and PN200-110. In the presence of the "slow" complexing Ca2+ buffer EGTA, homogenates exhibited T-tubule depolarization-induced Ca2+ release comprised of an initial rapid phase followed by a slower release phase. During the rapid phase, approximately 20% of the total sequestered Ca2+ (approximately 30 nmol 45Ca2+/mg protein), corresponding to 100% of the caffeine-sensitive Ca2+ pool, was released within 50 ms. Rapid release could be inhibited fourfold by D888. Addition to release media of the "fast" complexing Ca2+ buffer BAPTA, at concentrations > or = 4 mM, nearly abolished rapid Ca2+ release, suggesting that most was Ca2+ dependent. Addition of millimolar concentrations of either Ca2+ or Mg2+ also greatly reduced rapid Ca2+ release. These results show that T-tubule depolarization-induced SR Ca2+ release from rabbit skeletal muscle homogenates is controlled by T-tubule membrane potential- and by Ca(2+)- dependent mechanisms.
The diversity of diets in Syllidae (Annelida: Polychaeta)
Creators: name: GIANGRANDE, Adriana
name: LICCIANO, Margherita
name: PAGLIARA, Patrizia
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: Results from examination of fecal pellets and gut content of some syllid species (Polychaeta, Annelida) are
 reported. Specimens were collected from 0 to 20m depths along Apulian coast (Mediterranean Sea). Species collected at
 shallowest depth showed the presence of microalgae and macroalgae fragments in their guts and were considered herbivores.
 A prevalence of sediment grains in species from deeper samples together with animal or vegetal detritus, suggest that these
 are detritivores. Finally some species, collected at different depths, appeared as a mixture of the two previous categories and
 were considered omnivores. In addition in the omnivores, as well as in the detritivores, spicules of sponges or ascidians
 (Didemnidae) and bryozoan fragments could be present. Some assumptions were inferred from correlation of feeding
 structures with feeding categories in syllids. This paper represents a preliminary study, but it intends to warn against broad
 generalizations. Previous studies of trophic guilds, based on assumptions inferred from a few and old papers relative mainly
 to the genus Autolytus, considered all the Syllidae as mostly carnivores. Our observations suggest that the syllids are much
 more various in their diet than previously assumed, and that several of them are not carnivores.
(1854) Jane Johnson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Influencing Factors of Wage Increase Trend in Thailand (2022-2023)
Creators: name: Wanvicechanee Tanoamchard
Publisher: name: Doctor of Philosophy in Social Sciences Association Ramkhamhaeng University
Year: 2023
Subjects: Influencing Factors
Wage Increases
Wage Growth
ปัจจัยที่มีอิทธิพล
การปรับขึ้นค่าจ้าง
ค่าจ้างเพิ่มขึ้น

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 353-368
Fluctuation à long terme des peuplements macrobenthiques dans le golfe du Morbihan (Bretagne, France)
Creators: name: AFLI, Ahmed
name: GLÉMAREC, Michel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: Long-term fluctuation of macrobenthic communities in the Morbihan gulf (Brittany, France). The eastern part of
 the Morbihan gulf (south Brittany, France) is a confined area, where the anthropic actions (dredging, urban and agricultural
 inputs...) are increasingly significant. Other biotic and abiotic factors, in particular the climatic fluctuations and the
 introduction of exotic species, have an impact on the benthic ecosystem and modify the equilibrium between species within
 the assemblages. The use of ecological groups and the biotic indices method allows to detect the first signs of disturbance
 of the assemblages. In 1961, the macrofauna assemblages were poor in number of species and densities. They were
 dominated by sensitive species, mainly Bivalve Molluscs. Therefore, they seemed to be in a normal state. In 1995, the
 assemblages were much richer and reached very high densities. The dominance of tolerant and, especially, opportunistic
 species mainly Polychaetes, signifies that hypertrophic conditions are settled. Intermediate data (1969 and 1975) allow to
 well appreciate this 35-years evolution.
การวิเคราะห์เส้นทางความสัมพันธ์เชิงสาเหตุที่มีอิทธิพลต่อความตั้งใจในการใช้เทคโนโลยีการชำระเงินแบบอิเล็กทรอนิกส์ (E-Wallet) ในกรุงเทพมหานคร
Creators: name: ธีระชัย เจนเสถียร
name: ยุวรินธร ไชยโชติช่วง
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: รับรู้ถึงประโยชน์
รับรู้ถึงความง่ายในการใช้งาน
การชำระเงินแบบอิเล็กทรอนิกส์
ความไว้วางใจ
ความตั้งใจในการใช้เทคโนโลยี
Perceived Usefulness
Perceived Ease of Use
Electronic Payment
Trust
Intention to Use

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 369-383
The SDSS-IV in 2014: A Demographic Snapshot
Creators: name: Lundgren, Britt
name: Kinemuchi, Karen
name: Zasowski, Gail
name: Lucatello, Sara
name: Diamond-Stanic, Aleksandar M.
name: Tremonti, Christy A.
name: Myers, Adam D.
name: Aragon-Salamanca, Alfonso
name: Gillespie, Bruce
name: Ho, Shirley
name: Gallagher, John S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Many astronomers now participate in large international collaborations, and it is important to examine whether these structures foster a scientific climate that is inclusive and diverse. The Committee on the Participation of Women in the Sloan Digital Sky Survey (CPWS) was formed to evaluate the demographics and gender climate within SDSS-IV, one of the largest and most geographically distributed astronomical collaborations. In April 2014, the CPWS administered a demographic survey to establish a baseline for the incipient SDSS-IV. We received responses from 250 participants (46% of the active membership). Half of the survey respondents were located in the US or Canada and 30% were based in Europe. Eleven percent of survey respondents considered themselves to be an ethnic minority at their current institution. Twenty-five percent of the SDSS-IV collaboration members are women, a fraction that is consistent with the US astronomical community, but substantially higher than the fraction of women in the IAU (16%). Approximately equal fractions of men and women report holding positions of leadership. When binned by academic age and career level, men and women also assume leadership roles at approximately equal rates, in a way that increases steadily for both genders with increasing seniority. In this sense, SDSS-IV has been successful in recruiting leaders that are representative of the collaboration. Yet, more progress needs to be made towards achieving gender balance and increasing diversity in the field of astronomy, and there is still room for improvement in the membership and leadership of SDSS-IV. For example, at the highest level of SDSS-IV leadership, women disproportionately assume roles related to education and public outreach. The CPWS plans to use these initial data to establish a baseline for tracking demographics over time as we work to assess and improve the climate of SDSS-IV.
description: 16 pages, 13 figures, Accepted for publication in PASP
Imperatoxin A Induces Subconductance States in Ca 2+ Release Channels (Ryanodine Receptors) of Cardiac and Skeletal Muscle
Creators: name: Xu, L. E.
name: Valdivia, Hector H.
name: Meissner, Gerhard
name: Tripathy, Ashutosh
name: Resch, Wolfgang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Single-channel and [ 3 H]ryanodine binding experiments were carried out to examine the effects of imperatoxin activator (IpTx a ), a 33 amino acid peptide isolated from the venom of the African scorpion Pandinus imperator , on rabbit skeletal and canine cardiac muscle Ca 2+ release channels (CRCs). Single channel currents from purified CRCs incorporated into planar lipid bilayers were recorded in 250 mM KCl media. Addition of IpTx a in nanomolar concentration to the cytosolic ( cis ) side, but not to the lumenal ( trans ) side, induced substates in both ryanodine receptor isoforms. The substates displayed a slightly rectifying current–voltage relationship. The chord conductance at −40 mV was ∼43% of the full conductance, whereas it was ∼28% at a holding potential of +40 mV. The substate formation by IpTx a was voltage and concentration dependent. Analysis of voltage and concentration dependence and kinetics of substate formation suggested that IpTx a reversibly binds to the CRC at a single site in the voltage drop across the channel. The rate constant for IpTx a binding to the skeletal muscle CRC increased e-fold per +53 mV and the rate constant of dissociation decreased e-fold per +25 mV applied holding potential. The effective valence of the reaction leading to the substate was ∼1.5. The IpTx a binding site was calculated to be located at ∼23% of the voltage drop from the cytosolic side. IpTx a induced substates in the ryanodine-modified skeletal CRC and increased or reduced [ 3 H]ryanodine binding to sarcoplasmic reticulum vesicles depending on the level of channel activation. These results suggest that IpTx a induces subconductance states in skeletal and cardiac muscle Ca 2+ release channels by binding to a single, cytosolically accessible site different from the ryanodine binding site.
(1856) Margaret Caroline Johnson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Structure and dynamics of coupled viscous liquids
Creators: name: Ninarello, Andrea
name: Berthier, Ludovic
name: Coslovich, Daniele
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We perform Monte-Carlo simulations to analyse the structure and microscopic dynamics of a viscous Lennard-Jones liquid coupled to a quenched reference configuration of the same liquid. The coupling between the two replicas is introduced via a field epsilon conjugate to the overlap Q between the two particle configurations. This allows us to study the evolution of various static and dynamic correlation functions across the (epsilon, T) equilibrium phase diagram. As the temperature is decreased, we identify increasingly marked precursors of a first-order phase transition between a low-Q and a high-Q phase induced by the field epsilon. We show in particular that both static and dynamic susceptibilities have a maximum at a temperature-dependent value of the coupling field, which defines a `Widom line'. We also show that, in the high-overlap regime, diffusion and structural relaxation are strongly decoupled because single particle motion mostly occurs via discrete hopping on the sites defined by the reference configuration. These results, obtained using conventional numerical tools, provide encouraging signs that an equilibrium phase transition exists in coupled viscous liquids, but also demonstrate that important numerical challenges must be overcome to obtain more conclusive numerical evidence.
description: 14 pages, 8 figures. Accepted for publication in Molecular Physics (Special Issue in honour of J.-P. Hansen)
Dominant-Negative Mutants Identify a Role for Girk Channels in D3 Dopamine Receptor-Mediated Regulation of Spontaneous Secretory Activity
Creators: name: Oxford, Gerry S.
name: Kuzhikandathil, Eldo V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The human D3 dopamine receptor can activate G-protein–coupled inward rectifier potassium channels (GIRKs), inhibit P/Q-type calcium channels, and inhibit spontaneous secretory activity in AtT-20 neuroendocrine cells (Kuzhikandathil, E.V., W. Yu, and G.S. Oxford. 1998. Mol . Cell . Neurosci . 12:390–402; Kuzhikandathil, E.V., and G.S. Oxford. 1999. J . Neurosci . 19:1698–1707). In this study, we evaluate the role of GIRKs in the D3 receptor-mediated inhibition of secretory activity in AtT-20 cells. The absence of selective blockers for GIRKs has precluded a direct test of the hypothesis that they play an important role in inhibiting secretory activity. However, the tetrameric structure of these channels provides a means of disrupting endogenous GIRK function using a dominant negative approach. To develop a dominant-negative GIRK mutant, the K + selectivity amino acid sequence -GYG- in the putative pore domain of the human GIRK2 channels was mutated to -AAA-, -GLG-, or -GFG-. While the mutation of -GYG- to -GFG- did not affect channel function, both the -AAA- and -GLG- GIRK2 mutants were nonfunctional. This suggests that the aromatic ring of the tyrosine residue rather than its hydroxyl group is involved in maintaining the pore architecture of human GIRK2 channels. When expressed in AtT-20 cells, the nonfunctional AAA-GIRK2 and GLG-GIRK2 acted as effective dominant-negative mutants and significantly attenuated endogenous GIRK currents. Furthermore, these dominant-negative mutants interfered with the D3 receptor-mediated inhibition of secretion in AtT-20 cells, suggesting they are centrally involved in the signaling pathway of this secretory response. These results indicate that dominant-negative GIRK mutants are effective molecular tools to examine the role of GIRK channels in vivo.
Event coincidence analysis for quantifying statistical interrelationships between event time series: on the role of flood events as possible triggers of epidemic outbreaks
Creators: name: Donges, Jonathan F.
name: Schleussner, Carl-Friedrich
name: Siegmund, Jonatan F.
name: Donner, Reik V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Methodology (stat.ME)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Studying event time series is a powerful approach for analyzing the dynamics of complex dynamical systems in many fields of science. In this paper, we describe the method of event coincidence analysis to provide a framework for quantifying the strength, directionality and time lag of statistical interrelationships between event series. Event coincidence analysis allows to formulate and test null hypotheses on the origin of the observed interrelationships including tests based on Poisson processes or, more generally, stochastic point processes with a prescribed inter-event time distribution and other higher-order properties. Applying the framework to country-level observational data yields evidence that flood events have acted as triggers of epidemic outbreaks globally since the 1950s. Facing projected future changes in the statistics of climatic extreme events, statistical techniques such as event coincidence analysis will be relevant for investigating the impacts of anthropogenic climate change on human societies and ecosystems worldwide.
description: 18 pages, 4 figures
(1851) Jane Poole
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Two new species of Bulbamphiascus (Copepoda: Harpacticoida: Diosaccidae) and a related new genus, from the Bohai Sea, China.
Creators: name: MU, Fanghong
name: GEE, J. Michael
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: Bulbamphiascus plumosus sp.nov. and B. spinulosus sp. nov. are described from the Bohai Sea, China,
 provisionally placed in the genus Bulbamphiascus, and compared with specimens of the type species, B. imus, from near the
 type locality (off the Northumberland coast, U.K.). Both B. plumosus and B. spinulosus can be distinguished from B. imus
 by the spinulation patterns on the urosome, the form of the setae on the P5 exopod, and by the lack of sexual dimorphism
 on the basis of the male P2. B. plumosus can be distinguished from B. spinulosus by the lack of the ventral spinule row on
 the preanal somite, by the presence of a large plumose seta VI on the female caudal ramus (cf. short and smooth), by segment
 4 of the female antennule being only 1.5 times longer than broad (cf. 2.5 times) and by the lack of spinules on the anterior
 face of the male P2 endopod (cf. pronounced spinule patches). The relationship of the two new species to others in the genus
 is discussed.
 Bulbamphiascus imus is briefly redescribed and a neotype established. The flexible spine-like structure on the male P2
 endopod is described for the first time and its homology discussed. It is shown that, as presently constituted, B. imus is a
 complex of species, and probably is not cosmopolitan in distribution, as previously postulated.
 Sinamphiascus gen. nov. is established, to accommodate S. dominatus sp. nov., the most common sublittoral diosaccid in
 the Bohai Sea. The setation of the swimming legs identifies it as a Bulbamphiascus but the form of the P1 endopod (non-
 prehensile, segments almost equal in length), the antennule, the antenna, the female genital field, the spinulation of the
 urosome and caudal ramus, and sexually dimorphic characters on the male P1 basis and P2 endopod, all suggest a closer
 relationship with Haloschizopera.
Additional file 3 of A competence of embryo-derived tissues of tetraploid cultivated wheat species Triticum dicoccum and Triticum timopheevii for efficient and stable transgenesis mediated by particle inflow gun
Creators: name: Miroshnichenko, Dmitry
name: Klementyeva, Anna
name: Pushin, Alexander
name: Dolgov, Sergey
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 3: Table S1. Segregation analysis of GFP expression in T1 progeny of transgenic plants of emmer wheat ‘Runo’.
Ultrastructure of the proboscidial papillae in some Glycera species (Annelida: Polychaeta: Glyceridae)
Creators: name: BÖGGEMANN, Markus
name: FIEGE, Dieter
name: PURSCHKE, Günter
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: The ultrastructure of the proboscidial papillae in five species of Glycera: G. alba, G. lapidum, G. tesselata,
G. tridactyla, and G. unicornis is described based on transmission electron microscopy. The papillae are composed of four
 to five cells: one anterior mucous cell, one posterior serous cell and two to three multiciliated primary sensory cells which
 are presumed to be mechanoreceptors. The intracellular ciliary rootlets of the sensory cells are striated filamentous structures
 which might serve as skeletal elements. In two species (G. lapidum and G. tesselata) papillae sometimes bear lateral groups
 of cilia in addition to the cilia located apically. The physiological role of the papillae is discussed.
Polarized Signaling via Purinoceptors in Normal and Cystic Fibrosis Airway Epithelia
Creators: name: Boucher, Richard C.
name: Ribeiro, Carla M.P.
name: Paradiso, Anthony M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Airway epithelia are confronted with distinct signals emanating from the luminal and/or serosal environments. This study tested whether airway epithelia exhibit polarized intracellular free calcium (Ca 2+ i ) and anion secretory responses to 5′ triphosphate nucleotides (ATP/UTP), which may be released across both barriers of these epithelia. In both normal and cystic fibrosis (CF) airway epithelia, mucosal exposure to ATP/UTP increased Ca 2+ i and anion secretion, but both responses were greater in magnitude for CF epithelia. In CF epithelia, the mucosal nucleotide–induced response was mediated exclusively via Ca 2+ i interacting with a Ca 2+ -activated Cl − channel (CaCC). In normal airway epithelia (but not CF), nucleotides stimulated a component of anion secretion via a chelerythrine-sensitive, Ca 2+ -independent PKC activation of cystic fibrosis transmembrane conductance regulator. In normal and CF airway epithelia, serosally applied ATP or UTP were equally effective in mobilizing Ca 2+ i . However, serosally applied nucleotides failed to induce anion transport in CF epithelia, whereas a PKC-regulated anion secretory response was detected in normal airway epithelia. We conclude that (1) in normal nasal epithelium, apical/basolateral purinergic receptor activation by ATP/UTP regulates separate Ca 2+ -sensitive and Ca 2+ -insensitive (PKC-mediated) anion conductances; (2) in CF airway epithelia, the mucosal ATP/UTP-dependent anion secretory response is mediated exclusively via Ca 2+ i ; and (3) Ca 2+ i regulation of the Ca 2+ -sensitive anion conductance (via CaCC) is compartmentalized in both CF and normal airway epithelia, with basolaterally released Ca 2+ i failing to activate CaCC in both epithelia.
พฤติกรรมส่งเสริมสุขภาพเพื่อการพัฒนาคุณภาพชีวิตที่ดีของผู้สูงอายุ อำเภอฉวาง จังหวัดนครศรีธรรมราช
Creators: name: นฤมล รัตนไพจิตร
name: ตรีวนันท์ เนื่องอุทัย
name: ราตรี เขียวรอด
Publisher: name: สมาคมปรัชญาดุษฎีบัณฑิตทางสังคมศาสตร์ มหาวิทยาลัยรามคำแหง
Year: 2566
Subjects: พฤติกรรมส่งเสริมสุขภาพ
คุณภาพชีวิต
ผู้สูงอายุ
จังหวัดนครศรีธรรมราช
Health Promoting Behaviors
Quality of Life
The Elderly
Nakhon Si Thammarat Province

description: วารสารดุษฎีบัณฑิตทางสังคมศาสตร์, 13, 2, 384-398
(1848) Alexander Robinson Henderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Statistical modality tagging from rule-based annotations and crowdsourcing
Creators: name: Prabhakaran, Vinodkumar
name: Bloodgood, Michael
name: Diab, Mona
name: Dorr, Bonnie
name: Levin, Lori
name: Piatko, Christine D.
name: Rambow, Owen
name: Van Durme, Benjamin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: I.2.7; I.2.6; I.5.1; I.5.4

description: We explore training an automatic modality tagger. Modality is the attitude that a speaker might have toward an event or state. One of the main hurdles for training a linguistic tagger is gathering training data. This is particularly problematic for training a tagger for modality because modality triggers are sparse for the overwhelming majority of sentences. We investigate an approach to automatically training a modality tagger where we first gathered sentences based on a high-recall simple rule-based modality tagger and then provided these sentences to Mechanical Turk annotators for further annotation. We used the resulting set of training data to train a precise modality tagger using a multi-class SVM that delivers good performance.
description: 8 pages, 6 tables; appeared in Proceedings of the Workshop on Extra-Propositional Aspects of Meaning in Computational Linguistics, July 2012; In Proceedings of the Workshop on Extra-Propositional Aspects of Meaning in Computational Linguistics, pages 57-64, Jeju, Republic of Korea, July 2012. Association for Computational Linguistics
A new species of scale-worm (Polychaeta: Polynoidae), Levensteiniella plicata sp. nov., from the East Pacific Rise
Creators: name: HOURDEZ, Stéphane
name: DESBRUYÈRES, Daniel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: A new species of Macellicephalinae (Polychaeta: Polynoidae) from deep-sea hydrothermal vents is described.
 Levensteiniella plicata sp. nov. is found among the fauna associated with the mussel Bathymodiolus thermophilus, on the
 East Pacific Rise at 9°50' N. This large species was collected for the first time during the HOT'96 and HOPE'99 cruises.
Galaxy Formation with Local Photoionization Feedback -II. Effect of X-Ray Emission from Binaries and Hot Gas
Creators: name: Kannan, Rahul
name: Vogelsberger, Mark
name: Stinson, Greg S.
name: Hennawi, Joe F.
name: Marinacci, Federico
name: Springel, Volker
name: Maccio, Andrea V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study how X-rays from stellar binary systems and the hot intracluster medium (ICM) affect the radiative cooling rates of gas in galaxies. Our study uses a novel implementation of gas cooling in the moving-mesh hydrodynamics code \textsc{arepo}. X-rays from stellar binaries do not affect cooling at all as their emission spectrum is too hard to effectively couple with galactic gas. In contrast, X-rays from the ICM couple well with gas in the temperature range $10^4 - 10^6$ K. Idealised simulations show that the hot halo radiation field has minimal impact on the dynamics of cooling flows in clusters because of the high virial temperature ($> 10^7$K), making the interaction between the gas and incident photons very ineffective. Satellite galaxies in cluster environments, on the other hand, experience a high radiation flux due to the emission from the host halo. Low mass satellites ($< 10^{12}\rm{M_\odot}$) in particular have virial temperatures that are exactly in the regime where the effect of the radiation field is maximal. Idealised simulations of satellite galaxies including only the effect of host halo radiation (no ram pressure stripping or tidal effects) fields show a drastic reduction in the amount of cool gas formed ($\sim 40\%$) on a short timescale of about $0.5$ Gyrs. A galaxy merger simulation including all the other environmental quenching mechanisms, shows about $20\%$ reduction in the stellar mass of the satellite and about $\sim 30\%$ reduction in star formation rate after $1$ Gyr due to the host hot halo radiation field. These results indicate that the hot halo radiation fields potentially play an important role in quenching galaxies in cluster environments.
description: 14 pages, 12 figures, submitted to MNRAS
The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition
Creators: name: Tarran, Robert
name: Davis, C. William
name: Gatzy, John T.
name: Grubb, Barbara R.
name: Boucher, Richard C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Two hypotheses have been proposed recently that offer different views on the role of airway surface liquid (ASL) in lung defense. The “compositional” hypothesis predicts that ASL [NaCl] is kept low (<50 mM) by passive forces to permit antimicrobial factors to act as a chemical defense. The “volume” hypothesis predicts that ASL volume (height) is regulated isotonically by active ion transport to maintain efficient mechanical mucus clearance as the primary form of lung defense. To compare these hypotheses, we searched for roles for: (1) passive forces (surface tension, ciliary tip capillarity, Donnan, and nonionic osmolytes) in the regulation of ASL composition; and (2) active ion transport in ASL volume regulation. In primary human tracheobronchial cultures, we found no evidence that a low [NaCl] ASL could be produced by passive forces, or that nonionic osmolytes contributed substantially to ASL osmolality. Instead, we found that active ion transport regulated ASL volume (height), and that feedback existed between the ASL and airway epithelia to govern the rate of ion transport and volume absorption. The mucus layer acted as a “reservoir” to buffer periciliary liquid layer height (7 μm) at a level optimal for mucus transport by donating or accepting liquid to or from the periciliary liquid layer, respectively. These data favor the active ion transport/volume model hypothesis to describe ASL physiology.
Calmodulin Binding to the 3614–3643 Region of RyR1 Is Not Essential for Excitation–Contraction Coupling in Skeletal Myotubes
Creators: name: Dirksen, Robert T.
name: O'Connell, Kristen M.S.
name: Meissner, Gerhard
name: Yamaguchi, Naohiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Calmodulin is a ubiquitous Ca 2+ binding protein that modulates the in vitro activity of the skeletal muscle ryanodine receptor (RyR1). Residues 3614–3643 of RyR1 comprise the CaM binding domain and mutations within this region result in a loss of both high-affinity Ca 2+ -bound calmodulin (CaCaM) and Ca 2+ -free CaM (apoCaM) binding (L3624D) or only CaCaM binding (W3620A). To investigate the functional role of CaM binding to this region of RyR1 in intact skeletal muscle, we compared the ability of RyR1, L3624D, and W3620A to restore excitation–contraction (EC) coupling after expression in RyR1-deficient (dyspedic) myotubes. W3620A-expressing cells responded normally to 10 mM caffeine and 500 μM 4-chloro- m -cresol (4-cmc). Interestingly, L3624D-expressing cells displayed a bimodal response to caffeine, with a large proportion of cells (∼44%) showing a greatly attenuated response to caffeine. However, high and low caffeine-responsive L3624D-expressing myotubes exhibited Ca 2+ transients of similar magnitude after activation by 4-cmc (500 μM) and electrical stimulation. Expression of either L3624D or W3620A in dyspedic myotubes restored both L-type Ca 2+ currents (retrograde coupling) and voltage-gated SR Ca 2+ release (orthograde coupling) to a similar degree as that observed for wild-type RyR1, although L-current density was somewhat larger and activated at more hyperpolarized potentials in W3620A-expressing myotubes. The results indicate that CaM binding to the 3614–3643 region of RyR1 is not essential for voltage sensor activation of RyR1.
DEUX HALACARIENS ENDOPSAMMIQUES : HALACARUS ANOMALUS TROUESSART 1894 ET HALACARUS MARCANDREI N. SP.
Creators: name: MONNIOT, Françoise
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: The littoral sand of the Channel and Sweden contains two very similar species of Halacaridae : Halacarus anomalus which is redescribed and a new smaller species Halacarus marcandrei. The differences between the two species are established. The validity of the genus Anomohalacarus Newell is discussed.
Additional file 1 of Prognosis of papillary thyroid cancer in patients with Graves’ disease: a propensity score-matched analysis
Creators: name: Kwon, Hyungju
name: Byung-In Moon
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary Table 1. Patient demographics and pathologic features after propensity-score matching using age, sex and tumor size
The occurrence of Sipuncula in the Wagner and Consag Basins, Northern Gulf of California
Creators: name: HERMOSO-SALAZAR, Margarita
name: FRONTANA-URIBE, Sarita
name: SOLÍS-WEISS, Vivianne
name: PROL-LEDESMA, Rosa María
name: ESTRADAS-ROMERO, Alejandro
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Sipunculida collected in July-August 2010 from the Wagner and Consag Basins in the northern Gulf of California were analysed. This is a region in the northern Gulf of California approximately 700 km2 in area, 59-217 m in depth, and with intense gas hydrothermal activity. Salinity, temperature, pH, and sediment type were also measured. Sipunculids were collected at 25 stations (five families, eight genera and eight species). Where no sipunculans were found (11 stations), more intense gas seepage and very low pH (6.06 to 6.48) prevailed. Densities were generally low in the study area (1 to 8 ind. 0.1 m-2), except at station W-2 (10 ind. 0.1 m-2), due to the abundance of Onchnesoma steenstrupii steenstrupii. The species with the highest frequencies were Golfingiidae sp. (15 ind. 0.1 m-2) and O. steenstrupii steenstrupii (33 ind. 0.1 m-2). The spatial density and frequency fluctuations of the Sipunculida species in the study area seemed to be related to sediment type, pH, depth, and temperature. Golfingiidae sp., Phascolion sp. and Apionsoma (Apionsona) sp. are new records for the area, while distribution is extended towards north up to the Wagner and Consag Basins while Aspidosiphon (Akrikos) albus and Onchnesoma steenstrupii steenstrupii are new for the Eastern Pacific.