cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Landau damping for gravitational waves in parity-violating theories
Creators: name: Bombacigno, Flavio
name: Moretti, Fabio
name: Boudet, Simon
name: Olmo, Gonzalo J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We discuss how tensor polarizations of gravitational waves can suffer Landau damping in the presence of velocity birefringence, when parity symmetry is explicitly broken. In particular, we analyze the role of the Nieh-Yan and Chern-Simons terms in modified theories of gravity, showing how the gravitational perturbation in collisionless media can be characterized by a subluminal phase velocity, circumventing the well-known results of General Relativity and allowing for the appearance of the kinematic damping. We investigate in detail the connection between the thermodynamic properties of the medium, such as temperature and mass of the particles interacting with the gravitational wave, and the parameters ruling the parity violating terms of the models. In this respect, we outline how the dispersion relations can give rise in each model to different regions of the wavenumber space, where the phase velocity is subluminal, superluminal or does not exist. Quantitative estimates on the considered models indicate that the phenomenon of Landau damping is not detectable given the sensitivity of present-day instruments.
description: version accepted for publication in JCAP
Supplementary Methods from Inclusive fitness for in-laws
Creators: name: M. Dyble
name: A. Gardner
name: L. Vinicius
name: A. B. Migliano
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Additional methods, and Tables S1 and S2
Accelerated expansion from cosmological holography
Creators: name: van Putten, Maurice H. P. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is shown that holographic cosmology implies an evolving Hubble radius $c^{-1}\dot{R}_H = -1 + 3Ω_m$ in the presence of a dimensionless matter density $Ω_m$ scaled to the closure density $3H^2/8πG$, where $c$ denotes the velocity of light and $H$ and $G$ denote the Hubble parameter and Newton's constant. It reveals a dynamical dark energy and a sixfold increase in gravitational attraction to matter on the scale of the Hubble acceleration. It reproduces the transition redshift $z_t\simeq 0.4$ to the present epoch of accelerated expansion and is consistent with $(q_0,(dq/dz)_0)$ of the deceleration parameter $q(z)=q_0+(dq/dz)_0z$ observed in Type Ia supernovae.
description: 5 pages, 2 figures
title: Game-Based Simulation and Study of Pedestrian-Automated Vehicle Interactions
Creators: name: Pappas, Georgios
name: Siegel, Joshua E.
name: Kassens-Noor, Eva
name: Rutkowski, Jacob
name: Politopoulos, Konstantinos
name: Zorpas, Antonis A.
Publisher: name: MDPI
Year: 2022

description: We identify the need for enhanced pedestrian–vehicle simulation tools and build such a tool to explore the interaction among pedestrian "players" and virtual human- and automated-vehicles for different scenarios taking place in an urban environment. We first present contemporary research tools and then propose the design and development of a new desktop application that facilitates pedestrian-point-of-view research. We then conduct a three-step user experience experiment, in which a small number of participants answer questions before and after using the application to interact with virtual human and automated vehicles in diverse road-crossing scenarios. Behavioral results observed in virtuality, especially when motivated by consequence, tend to simulate real life sufficiently well to inform design choices. From the simulation, we observed valuable insights into human–vehicle interactions. Upon completing this preliminary testing, we iterated the tool’s design and ultimately conducted an 89-participant study of human–vehicle interactions for three scenarios taking place in a virtual environment. Our tool raised participant awareness of autonomous vehicles and their capabilities and limitations, which is an important step in overcoming public distrust of AVs. We additionally saw that participants trust humans and technology less as drivers than in other contexts, and that pedestrians feel safer around vehicles with autonomy indicators. Further, we note that study participants increasingly feel safe with automated vehicles with increased exposure. These preliminary results, as well as the efficacy of the tool’s design, may inform future socio-technical design for automated vehicles and their human interactions.
Transport of ultracold atoms in superpositions of S- and D-band states in a moving optical lattice
Creators: name: Yu, Zhongcheng
name: Tian, Jinyuan
name: Peng, Peng
name: Mao, Dekai
name: Chen, Xuzong
name: Zhou, Xiaoji
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The ultracold atoms in a moving optical lattice with its high controllability is a feasible platform to research the transport phenomenon. Here, we study the transport process of ultracold atoms at the D band in a one-dimensional optical lattice, and perform the manipulation of atomic transport by modulating the population proportion of S band and D band. In the experiment, we first load ultracold atoms into the optical lattice using shortcut method, and then accelerate the optical lattice by scanning the phase of lattice beams. The atomic transport in D band and S band is demonstrated respectively. We find the group velocity of atoms in D band is opposite to that in S band. By doping atoms of D band into that of S band, group velocity of the atomic superposition state is modulated, and the manipulation of atomic group velocity from positive to negative is realized. Furthermore, the influence of lattice depth and acceleration on the transport distance are studied. The calculations with multi-orbital simulation are coincident with the experimental results. Our work provides a useful method to manipulate the atomic transport in higher or mixed orbits.
description: 9 pages, 6 figures
Neutrophils alter epithelial response to Porphyromonas gingivalis in a gingival crevice model
Creators: name: Kinane, D.F.
name: Galicia, J.
name: Bondy-Carey, J.L.
name: Veillard, F.
name: Scott, D.A.
name: Potempa, J.S.
name: Bagaitkar, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A gingival crevice model (epithelial cell- Porphyromonas gingivalis – neutrophil) was established and used to profile gingipain, matrix metalloproteinase, MMP mediators (NGAL and TIMP-1) and cytokine networks. Smoking is the primary environmental risk factor for periodontitis. Therefore, the influence of cigarette smoke extract (CSE) was also monitored in the same model. P. gingivalis alone induced low levels of IL-1β and IL-8 from epithelial cells, but high levels of both cytokines were produced on the addition of neutrophils. CSE-exposure (100 and 1000 ng/ml nicotine equivalency) significantly compromised P. gingivalis-induced cytokine secretion (both p < 0.05). P. gingivalis induced impressive secretion of NGAL (p < 0.05) which was not influenced by CSE. The influence of CSE on gingipains production was strain-specific. Purified gingipains effectively and rapidly degraded both TIMP-1 and MMP-9. Induction of large amounts of NGAL, degradation of TIMP-1, and increased gingipain activity would each be expected to prolong collagen degradation and promote disease progression. However, gingipains also degrade MMP-9. Thus, P. gingivalis exerts a complex influence on the proteolytic balance of a gingival crevice model. CSE-exposure reduces the pro-inflammatory cytokine burden, which may be expected to promote P. gingivalis survival. In addition to novel findings that provide mechanistic insight into periodontal disease progression, these results are in keeping with the recognized clinical dogma of decreased inflammation / increased disease in smokers. Thus, this straightforward gingival crevice model is established as a suitable vehicle for the elucidation of mechanisms that contribute to susceptibility to periodontitis.
(400371) David Deuchars
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SOME SYNTACTIC FEATURES OF ENGLISH ORAL SPEECH AND THEIR ANALYSIS FROM THE POINT OF VIEW OF CONCEPTS OF CORRECTNESS OF SPEECH.
Creators: name: Mirzaholova, Nilufar
Publisher: name: Zenodo
Year: 2023

description: Finding orthological mistakes and its effect on language learning process is essential step for extracting knowledge about it. Anytime we face a lot of changes and loosing grammatical structures in English speaking.  Of course those situations lead to difficulties in grasping the language by its learners, as well as many contradictions, as well as to emergence of controversial situations.
Asteroids for ultralight dark-photon dark-matter detection
Creators: name: Fedderke, Michael A.
name: Mathur, Anubhav
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Gravitational-wave (GW) detectors that monitor fluctuations in the separation between inertial test masses (TMs) are sensitive to new forces acting on those TMs. Ultralight dark-photon dark matter (DPDM) coupled to $U(1)_B$ or $U(1)_{B-L}$ charges supplies one such force that oscillates with a frequency set by the DPDM mass. GW detectors operating in different frequency bands are thus sensitive to different DPDM mass ranges. A recent GW detection proposal based on monitoring the separation of certain asteroids in the inner Solar System would have sensitivity to $μ$Hz frequencies [arXiv:2112.11431]. In this paper, we show how that proposal would also enable access to new parameter space for DPDM coupled to $B$ [respectively, $B-L$] charges in the mass range $5\ [9] \times 10^{-21} \text{eV} \lesssim m_{\text{DM}} \lesssim 2 \times 10^{-19} \text{eV}$, with peak sensitivities about a factor of 500 [50] beyond current best limits on $\varepsilon_B$ [$\varepsilon_{B-L}$] at $m_{\text{DM}} \sim 2 \times 10^{-19} \text{eV}$. Sensitivity could be extended up to $m_{\text{DM}} \sim 2 \times 10^{-18} \text{eV}$ only if noise issues associated with asteroid rotational motion could be overcome.
description: 8 pages, 1 figure. Published version
Supporting Information for Multiscale Entropy Rate Analysis of Complex Mobile Agents from Multiscale entropy rate analysis of complex mobile agents.
Creators: name: Tuhin Paul
name: Stanley, Kevin G.
name: Osgood, Nathaniel D.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 80110 Simulation and Modelling
subject: FOS: Computer and information sciences

description: Detailed mathematical analysis
(400372) Annie Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Evaluation Metrics for Measuring Bias in Search Engine Results
Creators: name: Gezici, Gizem
name: Lipani, Aldo
name: Saygin, Yucel
name: Yilmaz, Emine
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Search engines decide what we see for a given search query. Since many people are exposed to information through search engines, it is fair to expect that search engines are neutral. However, search engine results do not necessarily cover all the viewpoints of a search query topic, and they can be biased towards a specific view since search engine results are returned based on relevance, which is calculated using many features and sophisticated algorithms where search neutrality is not necessarily the focal point. Therefore, it is important to evaluate the search engine results with respect to bias. In this work we propose novel web search bias evaluation measures which take into account the rank and relevance. We also propose a framework to evaluate web search bias using the proposed measures and test our framework on two popular search engines based on 57 controversial query topics such as abortion, medical marijuana, and gay marriage. We measure the stance bias (in support or against), as well as the ideological bias (conservative or liberal). We observe that the stance does not necessarily correlate with the ideological leaning, e.g. a positive stance on abortion indicates a liberal leaning but a positive stance on Cuba embargo indicates a conservative leaning. Our experiments show that neither of the search engines suffers from stance bias. However, both search engines suffer from ideological bias, both favouring one ideological leaning to the other, which is more significant from the perspective of polarisation in our society.
Convexity at infinity in Cartan-Hadamard manifolds and applications to the asymptotic Dirichlet and Plateau problems
Creators: name: Casteras, Jean-baptiste
name: Holopainen, Ilkka
name: Ripoll, Jaime
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We study the asymptotic Dirichlet and Plateau problems on Cartan-Hadamard manifolds satisfying the so-called Strict Convexity (abbr. SC) condition. The main part of the paper consists in studying the SC condition on a manifold whose sectional curvatures are bounded from above and below by certain functions depending on the distance to a fixed point. In particular, we are able to verify the SC condition on manifolds whose curvature lower bound can go to -infinity and upper bound to 0 simultaneously at certain rates, or on some manifolds whose sectional curvatures go to -infinity faster than any prescribed rate. These improve previous results of Anderson, Borbély, and Ripoll and Telichevsky. We then solve the asymptotic Plateau problem for locally rectifiable currents with Z_2-multiplicity in a Cartan-Hadamard manifold satisfying the SC condition given any compact topologically embedded (k-1)-dimensional submanifold of \partial_{\infty}M, 2\leq k\leq n-1, as the boundary data. We also solve the asymptotic Plateau problem for locally rectifiable currents with Z-multiplicity on any rotationally symmetric manifold satisfying the SC condition given a smoothly embedded submanifold as the boundary data. These generalize previous results of Anderson, Bangert, and Lang. Moreover, we obtain new results on the asymptotic Dirichlet problem for a large class of PDEs. In particular, we are able to prove the solvability of this problem on manifolds with super-exponential decay (to -infinity) of the curvature.
description: This is a corrected and improved version. We thank Urs Lang for his valuable comments on previous versions, in particular, for pointing out an incorrect assumption in Theorem 1.5 in the first version
An Efficient Coding Method for Coding Region-of-Interest Locations in AVS2
Creators: name: Chen, Mingliang
name: Lin, Weiyao
name: Zheng, Xiaozhen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Region-of-Interest (ROI) location information in videos has many practical usages in video coding field, such as video content analysis and user experience improvement. Although ROI-based coding has been studied widely by many researchers to improve coding efficiency for video contents, the ROI location information itself is seldom coded in video bitstream. In this paper, we will introduce our proposed ROI location coding tool which has been adopted in surveillance profile of AVS2 video coding standard (surveillance profile). Our tool includes three schemes: direct-coding scheme, differential- coding scheme, and reconstructed-coding scheme. We will illustrate the details of these schemes, and perform analysis of their advantages and disadvantages, respectively.
description: This manuscript is the accepted version for ICMEW (IEEE Intl. Conf. Multimedia & Expo Workshop), IEEE Intl. Conf. Multimedia & Expo Workshop (ICME), 2014
On the generalized Kesten--McKay distributions
Creators: name: Szabłowski, Paweł J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We examine the properties of distributions with the density of the form: $% \frac{2A_{n}c^{n-2}\sqrt{c^{2}-x^{2}}}{π\prod_{j=1}^{n}(c(1+a_{j}^{2})-2a_{j}x)},$ where $c,a_{1},\ldots ,a_{n}$ are some parameters and $A_{n}$ a suitable constant. We find general forms of $% A_{n}$, of $k-$th moment and of $k-$th polynomial orthogonal with respect to such measures. We also calculate Cauchy transforms of these measures. We indicate connections of such distributions with distributions and polynomials forming the so-called Askey--Wilson scheme. On the way, we prove several identities concerning rational symmetric functions. Finally, we consider the case of parameters $a_{1},\ldots ,a_{n}$ forming conjugate pairs and give some multivariate interpretations based on the obtained distributions at least for the cases $n=2,4,6.$
description: 14 pages
Intrathecal Long-Term Gene Expression by Self-Complementary Adeno-Associated Virus type 1 Suitable for Chronic Pain Studies in Rats
Creators: name: Storek, Benjamin
name: McCarty, Douglas M
name: Wang, Cheng
name: Banck, Michaela S
name: Morrison, John H
name: Harder, Nina M
name: Beutler, Andreas S
name: Janssen, William GM
name: Walsh, Christopher E
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: BackgroundIntrathecal (IT) gene transfer is an attractive approach for targeting spinal mechanisms of nociception but the duration of gene expression achieved by reported methods is short (up to two weeks) impairing their utility in the chronic pain setting. The overall goal of this study was to develop IT gene transfer yielding true long-term transgene expression defined as ≥ 3 mo following a single vector administration. We defined "IT" administration as atraumatic injection into the lumbar cerebrospinal fluid (CSF) modeling a lumbar puncture. Our studies focused on recombinant adeno-associated virus (rAAV), one of the most promising vector types for clinical use.ResultsConventional single stranded rAAV2 vectors performed poorly after IT delivery in rats. Pseudotyping of rAAV with capsids of serotypes 1, 3, and 5 was tested alone or in combination with a modification of the inverted terminal repeat. The former alters vector tropism and the latter allows packaging of self-complementary rAAV (sc-rAAV) vectors. Combining both types of modification led to the identification of sc-rAAV2/l as a vector that performed superiorly in the IT space. IT delivery of 3 × 10e9 sc-rAAV2/l particles per animal led to stable expression of enhanced green fluorescent protein (EGFP) for ≥ 3 mo detectable by Western blotting, quantitative PCR, and in a blinded study by confocal microscopy. Expression was strongest in the cauda equina and the lower sections of the spinal cord and only minimal in the forebrain. Microscopic examination of the SC fixed in situ with intact nerve roots and meninges revealed strong EGFP fluorescence in the nerve roots.Conclusionsc-rAAVl mediates stable IT transgene expression for ≥ 3 mo. Our findings support the underlying hypothesis that IT target cells for gene transfer lack the machinery for efficient conversion of the single-stranded rAAV genome into double-stranded DNA and favor uptake of serotype 1 vectors over 2. Experiments presented here will provide a rational basis for utilizing IT rAAV gene transfer in basic and translational studies on chronic pain.
(400369) Jane Wilson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 57 Nr. 3 (2016): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
title: Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
titleType: AlternativeTitle
Creators: name: Burgen Und Schlösser-Zeitschrift Für Burgenforschung Und Denkmalpflege
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2022

description: Anmerkungen zur Restaurierung des Josephskreuzes auf dem Auerberg im Ostharz – die Gräfliche Familienheraldik von 1896...177-181 Baudenkmale gefährdet – Baudenkmale gerettet...185-186 Inszenierung der Antike. Klassizistische Dekoration der Ismaninger Schloss-Säle...183 Maueranker und Stier. Plesse/ Plessen. Tausend Jahre eines norddeutschen Adelsgeschlechtes...188-191 Bernhard Rüth / Dorothee Ade / Cajetan Schaub (Hrsg.), Adelssitze zwischen Schwarzwald und Schwäbischer Alb; Casimir Bumiller, Krieg Fehde Belagerung...187-188 Barock – Nur schöner Schein?...184 Adelskulturen auf Burgen...181-182 Forschungen am Außenzwinger der Burg Rechberg (Hohenrechberg) bei Schwäbisch Gmünd...147-158 Inhalt
Interaction of α-Synuclein and a Cell Penetrating Fusion Peptide with Higher Eukaryotic Cell Membranes Assessed by 19 F NMR
Creators: name: Pielak, Gary J.
name: Zigoneanu, Imola G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: We show that fluorine NMR can be used to monitor the insertion and change in conformation of a 19F-labeled cell-penetrating peptide upon interacting with the cellular plasma membrane. α-Synuclein and a construct comprising a cell-penetrating peptide covalently attached to its N-terminus were studied. Important information about the interaction of the proteins with CHO-K1 cells was obtained by monitoring the diminution of 19F resonances of 3-fluoro-L-tyrosine labeled proteins. For α-synuclein, a decrease in the resonance from position 39 was observed indicating that only the N-terminal third region of the protein interacts with plasma membrane. However, when the fusion construct was incubated with the cells, a decrease in the resonance from the fusion peptide region was noted with no change in the resonances from α-synuclein region. Longer incubation, studied by using confocal fluorescence microscopy, revealed that the fusion construct translocates into the cells, but α-synuclein alone did not cross the membrane in significant amounts.
Nanoparticle Delivery of Pooled siRNA for Effective Treatment of Non-Small Cell Lung Caner
Creators: name: Yang, Yang
name: Wang, Yuhua
name: Liu, Feng
name: Hu, Yunxia
name: Huang, Leaf
name: Li, Jun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. To explore the potential of small interfering RNA (siRNA) therapy for NSCLC, we have developed anisamide-targeted LCP to efficiently deliver siRNA into the cytoplasm of sigma receptor-expressing NSCLC cells. Targeted LCP demonstrated a 9-fold higher siRNA delivery efficiency compared to non-targeted LCP in A549 cells in vitro. To simultaneously target multiple oncogenic mechanisms, we co-formulated three siRNA sequences targeting HDM2, c-myc and VEGF oncogenes, and investigated their efficacy of cell-killing in A549 and H460 cells in vitro. The results indicated that the pooled siRNA co-delivered by the targeted LCP could effectively and simultaneously knock down HDM2, c-myc and VEGF expressions and significantly inhibit tumor cell growth. After i.v. injection of mice bearing A549 xenografted tumor with Texas Red-labeled siRNA formulated in the targeted LCP, siRNA was successfully delivered to and concentrated in the tumor cells. Repeated intravenous injections of mice with pooled siRNA formulated in the targeted LCP significantly impaired NSCLC growth in vivo (p < 0.01) for both A549 and H460 tumors, demonstrating an ED50 for the treatment of ~0.2 mg/kg in A549 tumors. The enhanced anti-tumor activity is due to the fact that the silencing of HDM2/c-myc/VEGF could inhibit tumor proliferation and angiogenesis and also simultaneously induce tumor apoptosis. Our results demonstrate that the targeted LCP is a promising vector to deliver pooled siRNA into tumors and to achieve multiple target blocking. This is potentially a valid therapeutic modality in the gene therapy of human NSCLC.
Targeted Delivery of a Splice-Switching Oligonucleotide by Cationic Polyplexes of RGD-Oligonucleotide Conjugate
Creators: name: Ming, Xin
name: Feng, Lan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Nanoparticle-based delivery has become an important strategy to advance therapeutic oligonucleotides into clinical reality. Delivery by nanocarriers can enhance access of oligonucleotides to their pharmacological targets within cells; preferably, targeting ligands are incorporated into nanoparticles for targeting oligonucleotides to disease sites, often by conjugation to delivery carriers. In this study, a splice-switching oligonucleotide (SSO) was conjugated to a bivalent RGD peptide, and then, the RGD-SSO conjugate was formulated into polyplexes with a cationic polymer polyethylenimine. The resultant polyplexes of RGD-oligonucleotide conjugate demonstrated dramatic increase in the pharmacological response of splicing correction compared to free RGD-SSO conjugate or the polyplexes of unconjugated SSO, through integrin-mediated endocytosis and rapid endosomal release. This study has shown that coupling a targeting ligand to cargo oligonucleotide can maintain the integrin targeting ability after the peptide-oligonucleotide conjugate is complexed with cationic polymer. Preliminary study also revealed that integrin targeting redirects intracellular trafficking of the polyplexes to caveolar pathway and thereby generates greater effectiveness of the oligonucleotide. This study provides a new platform technology to construct multifunctional delivery systems of therapeutic oligonucleotides.
Trp2 Peptide Vaccine Adjuvanted with ( R )-DOTAP Inhibits Tumor Growth in an Advanced Melanoma Model
Creators: name: Huang, Leaf
name: Zhang, Yuan
name: Vasievich, Elizabeth A.
name: Ramishetti, Srinivas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Previously we have shown cationic lipid (R)-DOTAP as the immunologically active enantiomer of the DOTAP racemic mixture, initiating complete tumor regression in an exogenous antigen model (murine cervical cancer model). Here, we investigate the use of (R)-DOTAP as an efficacious adjuvant delivering an endogenous antigen in an aggressive murine solid tumor melanoma model. (R)-DOTAP/Trp2 peptide complexes showed decreasing size and charge with increasing peptide concentration, taking a rod-shape at highest concentrations. The particles were stable for at 2 weeks at 4°C. A dose of 75nmol Trp2 (formulated in (R)-DOTAP) was able to show statistically significant tumor growth delay compared to lower doses of 5 and 25nmol which were no different than untreated tumors. (R)-DOTAP/Trp2 (75nmol) treated mice also showed increased T cell IFN-γ secretion after restimulation with Trp2, as well as CTL activity in vivo. This vaccination group also showed the highest population of functionally active tumor-infiltrating lymphocytes, indicated by IFN-γ secretion after restimulation with Trp2. Thus, (R)-DOTAP has shown the ability to break tolerance as an adjuvant. Its activity to enhance immunogenicity of other tumor associated antigens should be studied further.
Supporting Information for Multiscale Entropy Rate Analysis of Complex Mobile Agents from Multiscale entropy rate analysis of complex mobile agents
Creators: name: Tuhin Paul
name: Stanley, Kevin G.
name: Osgood, Nathaniel D.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 80110 Simulation and Modelling
subject: FOS: Computer and information sciences

description: Detailed mathematical analysis
Exotic $μτj j$ events from heavy ISS neutrinos at the LHC
Creators: name: Arganda, E.
name: Herrero, M. J.
name: Marcano, X.
name: Weiland, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this letter we study new relevant phenomenological consequences of the right-handed heavy neutrinos with masses at the ${\cal O}(1)$ TeV energy scale, working within the context of the Inverse Seesaw Model that includes three pairs of quasi-degenerate pseudo-Dirac heavy neutrinos. We propose a new exotic signal of these heavy neutrinos at the CERN Large Hadron Collider containing a muon, a tau lepton, and two jets in the final state, which is based on the interesting fact that this model can incorporate large Lepton Flavor Violation for specific choices of the relevant parameters, particularly, the neutrino Yukawa couplings. We will show here that an observable number of $μτjj$ exotic events, without missing energy, can be produced at this ongoing run of the LHC.
description: 7 pages, 4 figures. This version v3 matches the manuscript published in Physics Letters B
Conjugates of Superoxide Dismutase 1 with Amphiphilic Poly(2-oxazoline) Block Copolymers for Enhanced Brain Delivery: Synthesis, Characterization and Evaluation in Vitro and in Vivo
Creators: name: Banks, William A.
name: Tong, Jing
name: Jordan, Rainer
name: Zimmerman, Matthew C.
name: Luxenhofer, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Superoxide dismutase 1 (SOD1) efficiently catalyzes dismutation of superoxide but its poor delivery to the target sites in the body, such as brain, hinders its use as a therapeutic agent for superoxide-associated disorders. Here to enhance the delivery of SOD1 across the blood brain barrier (BBB) and in neurons the enzyme was conjugated with poly(2-oxazoline) (POx) block copolymers, P(MeOx-b-BuOx) or P(EtOx-b-BuOx), comprised of 1) hydrophilic 2-methyl-2-oxazoline (MeOx) or 2-ethyl-2-oxazoline (EtOx) and 2) hydrophobic 2-butyl-2-oxazoline (BuOx) repeating units. The conjugates contained from 2 to 3 POx chains joining the protein amino groups via cleavable -(ss)- or non-cleavable –(cc)- linkers at the BuOx block terminus. They retained 30% to 50% of initial SOD1 activity, were conformationally and thermally stable and assembled in 8 or 20 nm aggregates in aqueous solution. They had little if any toxicity to CATH.a neurons and displayed enhanced uptake in these neurons as compared to native or PEGylated SOD1. Of the two conjugates, SOD1-(cc)-P(MeOx-b-BuOx) and SOD1-(cc)-P(EtOx-b-BuOx) compared, the latter was entering cells 4 to 7 times faster and at 6 h colocalized predominantly with endoplasmic reticulum (41 ± 3%) and mitochondria (21 ± 2%). Colocalization with endocytosis markers and pathway inhibition assays suggested that it was internalized through lipid raft/caveolae, also employed by the P(EtOx-b-BuOx) copolymer. The SOD activity in cell lysates and ability to attenuate angiotensin II (Ang II)-induced superoxide in live cells were increased for this conjugate compared to SOD1 and PEG-SOD1. Studies in mice showed that SOD1-POx had ca. 1.75 times longer half-life in blood than native SOD1 (28.4 vs 15.9 min) and after i.v. administration penetrated the BBB significantly faster than albumin to accumulate in brain parenchyma. The conjugate maintained high stability both in serum and in brain (77% vs. 84% at 1 h post injection). Its amount taken up by the brain reached a maximum value of 0.08%ID/g (percent of the injected dose taken up per gram of brain) 4 h post injection. The entry of SOD1-(cc)-P(EtOx-b-BuOx) to the brain was mediated by a non-saturable mechanism. Altogether, SOD1-POx conjugates are promising candidates as macromolecular antioxidant therapies for superoxide-associated diseases such as Ang II induced neuro-cardiovascular diseases.
title: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1 Nr. 1 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
title: Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
titleType: AlternativeTitle
Creators: name: Burgen Und Schlösser-Zeitschrift Für Burgenforschung Und Denkmalpflege
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: Burgen- und Fremdenverkehr...34 Andenkenverkauf auf Burgen und Schlössern...34 Burgenbericht aus Mitteldeutschland...34 Stadtbefestigung Aach gefährdet...33 Burgenfahrt durch Hessen...33 Burgenfahrt des österreichischen Burgenvereins. Südtirol 6. bis 7. September 1959...33 Burgenfahrt des JBJ...33 Burgenfahrt der Deutschen Burgenvereinigung. Kärnten, Steiermark, Burgenland 13. bis 18. Juni 1959...32-33 Bild- und Presse-Archiv...32 Arbeitsausschüsse der DBV...32 Register Burgen und Schlösser. Kauf und Verkauf / Anstellung suchen...41 Bauberatungs- und Firmen-Kartei...39-40 Schrifttum der Burgenkunde. Buchbesprechungen und Schrifttums-Nachweisungen...35-38 Die Deutsche Burgenvereinigung e.V....30-31 Burgen-Denkmalpflege in Bayern...30 Die Stadtbefestigung von Nürnberg. Kriegszerstörung und Wiederaufbau...28-29 Zur Burgenkunde in Rheinland-Pfalz...27 Burgenerhaltung und Burgenforschung im Rheinland...26 Burgendenkmalpflege und Burgenforschung in Slovenien...25 Burgenkommission der österreichischen Akademie der Wissenschaften...24-25 Dokumentation der Burgenkunde und Burgenforschung...22-23 Steuerbewertung historischer Bauwerke...21-22 Versteuerung von Besichtigungsentgelten...20 Burg im Raum. Eine neue Aufgabe der Burgenforschung...17-19 Bergfried - Berchfrit. Wort und Begriff...16 Der romanische Schornstein am Berchfrit zu Neipperg...15-16 Gotische Berchfrit-Formen im rheinisch-hessischen Raum...12-14 Grundsätze für die moderne Burgenforschung...8-11 Sinnbilder und Kennzeichen historischen Wehrbauten und Schlösser. Ein Hilfsmittel zur Klassifikation...6-7 Romanische Burgengrundrisse. Skizze einer Typologie...4-6 Zum Problem der Burgentypologie...2-3 Vorwort...1 Inhalt
Supplementary Figures from Host species, pathogens and disease associated with divergent nasal microbial communities in tortoises.
Creators: name: Weitzman, Chava L.
name: Sandmeier, Franziska C.
name: C. Richard Tracy
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Five supplementary figures including rarefaction curves, site-level boxplots of OTU richness, and core microbiome information for host species and sampling sites.
A search for pair halos around active galactic nuclei through a temporal analysis of Fermi-LAT data
Creators: name: Prokhorov, D. A.
name: Moraghan, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We develop a method to search for pair halos around active galactic nuclei (AGN) through a temporal analysis of gamma-ray data. The basis of our method is an analysis of the spatial distributions of photons coming from AGN flares and from AGN quiescent states and a further comparison of these two spatial distributions. This method can also be used for a reconstruction of a point spread function (PSF). We found no evidence for a pair halo component through this method by applying it to the Fermi-LAT data in the energy bands of 4.5-6, 6-10, and >10 GeV and set upper limits on the fraction of photons attributable to a pair halo component. An illustration of how to reconstruct the PSF of Fermi-LAT is given. We demonstrate that the PSF reconstructed by using this method is in good agreement with that which was obtained by using the gamma-ray data taken by LAT in the direction of the Crab pulsar and nebula.
description: 14 pages, 1 figure, a typo corrected. The version published in MNRAS
Splay Top Trees
Creators: name: Holm, Jacob
name: Rotenberg, Eva
name: Ryhl, Alice
Publisher: name: arXiv
Year: 2022
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: E.1; F.2

description: The top tree data structure is an important and fundamental tool in dynamic graph algorithms. Top trees have existed for decades, and today serve as an ingredient in many state-of-the-art algorithms for dynamic graphs. In this work, we give a new direct proof of the existence of top trees, facilitating simpler and more direct implementations of top trees, based on ideas from splay trees. This result hinges on new insights into the structure of top trees, and in particular the structure of each root path in a top tree.
description: 27 pages, 6 figures, published at SOSA'23, license information updated
title: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 1 Nr. 2 (1960): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
title: Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
titleType: AlternativeTitle
Creators: name: Burgen Und Schlösser-Zeitschrift Für Burgenforschung Und Denkmalpflege
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2017

description: Die Anfrage auf Kauf oder Pacht / Verkauf und Verpachtung von Burgen und Schlössern...36-37 Burgennachrichten aus Nord- und Süddeutschland [Teil II]...36 Schrifttum der Burgenkunde. Buchbesprechungen und Schrifttums-Nachweisungen...35 Burgennachrichten aus Nord- und Süddeutschland [Teil I]...34 Schrifttum der Burgenkunde. Buchbesprechungen und Schrifttums-Nachweisungen...33 Ausbau und Baupflege von Burgen, Schlössern und Landsitzen...32 Die Deutsche Burgenvereinigung e.V....31-32 Deutsche Burgen und Schlösser zwischen Harz und Oder und ihre heutige Verwendung...28-31 Burgennachrichten aus Mittel- und Ostdeutschland [Teil 2]...27 Erhaltung und Erforschung von Herrenhäusern in Schleswig-Holstein...27 Burgen- und Schlösserforschung und -erhaltung in Niedersachsen...23-26 Das Purchstal...21-22 Die Falkenburg im Kyffhäuser. Neue Ergebnisse der Datierung...19-20 Burgennachrichten aus Mittel- und Ostdeutschland [Teil I]...18 Romanische Mauerwerkstechnik auf fränkischen Burgen...16-18 Burgen in Burgund / Les châteaux-forts en Bourgogne...13-15 Die Neugestaltung der Godesburg...11-12 Die Wiederherstellung der Wartburg...9-10 Neuentdeckte Fresken auf Burg Lichtenberg...7-9 Die Anfänge des Festungsbaues. Zur Entwicklung der Bastionärbefestigung während des 15. und 16. Jahrhunderts im östlichen Mittelmeergebiet...1-6 Inhaltsverzeichnis
Supplementary Figures from Host species, pathogens and disease associated with divergent nasal microbial communities in tortoises
Creators: name: Weitzman, Chava L.
name: Sandmeier, Franziska C.
name: C. Richard Tracy
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Five supplementary figures including rarefaction curves, site-level boxplots of OTU richness, and core microbiome information for host species and sampling sites.
(400370) Jane [jeannie] Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
How Does the Cell Overcome LCP Nanoparticle-Induced Calcium Toxicity?
Creators: name: Huang, Leaf
name: Tseng, Yu-Cheng
name: Yang, Angela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To address the question of how cells respond to the possible Ca2+ toxicity caused by the release of Ca2+ into the cytoplasm by LCP nanoparticles, a series of in vitro and in vivo studies using Ca2+ pump inhibitors were conducted. The results indicated that two major Ca2+ pumps on the plasma membrane and the mitochondrial membrane, respectively, were able to rapidly respond to the elevated cytosolic Ca2+ concentration and prevent Ca2+-induced apoptosis or necrosis. However, exposure to specific inhibitors of calcium pumps would cause LCP-treated H460 cells to undergo necrosis both in vitro and in vivo. These results demonstrated that the Ca2+ delivered by LCP was not toxic to cells when the cells contain functional Ca2+ pumps.
Multifunctional Nanoparticles Based on a Single-Molecule Modification for the Treatment of Drug-Resistant Cancer
Creators: name: Tang, Jingling
name: Racette, Kelly
name: Fu, Qiang
name: Wang, Yongjun
name: Liu, Feng
name: Ramishetti, Srinivas
name: Wang, Dun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively explored for the treatment of MDR in cancer because of its ability to inhibit P-glycoprotein. Here, we have established multifunctional nanoparticles (MFNPs) using a single-molecule modification of TPGS, which can deliver a hydrophobic drug, paclitaxel (PTX), and a hydrophilic drug, fluorouracil (5-FU), and overcome MDR in cancer. Our data indicated that, when delivered into a PTX-resistant cell line using MFNPs, the combination of PTX and 5-FU was more cytotoxic than each agent individually.
Functional Form of the Imaginary Part of the Atomic Polarizability
Creators: name: Jentschura, U. D.
name: Pachucki, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The dynamic atomic polarizability describes the response of the atom to incoming electromagnetic radiation. The functional form of the imaginary part of the polarizability for small driving frequencies omega has been a matter of long-standing discussion, with both a linear dependence and an omega^3 dependence being presented as candidate formulas. The imaginary part of the polarizability enters the expressions of a number of fundamental physical processes which involve the thermal dissipation of energy, such as blackbody friction, and non-contact friction. Here, we solve the long-standing problem by calculating the imaginary part of the polarizability in both the length (d.E) as well as the velocity-gauge (p.A) form of the dipole interaction, verify the gauge invariance, and find general expressions applicable to atomic theory; the omega^3 form is obtained in both gauges. The seagull term in the velocity gauge is found to be crucial in establishing gauge invariance.
description: 10 pages; RevTeX; accepted for publication in Eur.Phys.J.D
Ultrahigh-energy cosmic-ray signature in GRB 221009A
Creators: name: Das, Saikat
name: Razzaque, Soebur
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The brightest long gamma-ray burst detected so far by the Swift-BAT and Fermi-GBM telescopes, GRB~221009A, provides an unprecedented opportunity for understanding the high-energy processes in extreme transient phenomena. We find that the conventional leptonic models, synchrotron and synchrotron-self-Compton, for the afterglow emission from this source have difficulties explaining the observation of $\gtrsim 10$ TeV $γ$ rays, by the LHAASO detector, and extending up to 18 TeV energies. We model $γ$-ray spectrum estimated in the energy range 0.1-1 GeV by the Fermi-LAT detector. The flux predicted by our leptonic models is severely attenuated at $> 1$ TeV due to $γγ$ pair production with extragalactic background light, and hence an additional component is required at $\gtrsim 10$ TeV. Ultrahigh-energy cosmic rays can be accelerated in the GRB blastwave, and their propagation induces an electromagnetic cascade in the extragalactic medium. The line of sight component of this flux can explain the emission at $\gtrsim 10$ TeV detected by LHAASO, requiring a fraction of the GRB blastwave energy in ultrahigh-energy cosmic rays. This could be an indication of ultrahigh-energy cosmic-ray acceleration in GRBs.
description: 4 pages, 2 figures, Accepted for publication in A&A Letters
Supplementary Material from The left ventral premotor cortex is involved in hand shaping for intransitive gestures: evidence from a two-person imitation experiment.
Creators: name: Reader, Arran T.
name: Holmes, Nicholas P.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Neuroscience
subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology

description: This file features all supplementary tables and figures