cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kinetic Modelling of Hydrogenation of Cardanol over Pd/C Catalyst
Creators: name: Bhagwat R. Patil
name: Bari, Atul H.
name: Pinjari, Dipak V.
name: Aniruddha B. Pandit
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The catalytic hydrogenation of cardanol was studied in a stirred three-phase-slurry reactor using palladium on carbon, often referred to as the Pd/C catalyst (5% loading of palladium is supported on activated carbon powder). The effects of various process parameters were examined. The kinetics of hydrogenation, which proceeds through three parallel–series reactions, was investigated. The reaction was observed to be of first order with respect to both hydrogen and cardanol. A simple second-order series reaction model was well fitted to the experimental data. Also, the Langmuir–Hinshelwood–Hougen–Watson approach was used to interpret the possible mechanistic behaviour of the reaction. It was observed that the reaction follows dual site, competitive and dissociative type of adsorption of hydrogen. Surface reaction of the adsorbed reactants was identified as the overall rate controlling step. Various rate constants and adsorption equilibrium constants for the different steps were also estimated. Different thermodynamic parameters associated with these constants were obtained to assess their physical significance. Also, these constants were evaluated statistically using the F-test and t-test.
Ziram inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase
Creators: name: Su, Ying
name: Li, Huitao
name: Chen, Xiaomin
name: Wang, Yiyan
name: Li, Xiaoheng
name: Sun, Jianliang
name: Ge, Ren-Shan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: The neurotoxicity of ziram is largely unknown. In this study, we investigated the direct inhibitions of ziram on rat neurosteroid synthetic and metabolizing enzymes, 5α-reductase 1 (SRD5A1), 3α-hydroxysteroid dehydrogenase (AKR1C14), and retinol dehydrogenase 2 (RDH2). Rat SRD5A1, AKR1C14, and RDH2 were cloned and transiently expressed in COS1 cells, and the effects of ziram on these enzymes were measured. Ziram inhibited rat SRD5A1 and AKR1C14 with IC50 values of 1.556 ± 0.078 and 1.017 ± 0.072 μM, respectively, when 1000 nM steroid substrates were used. Ziram weakly inhibited RDH2 at 100 μM, when androstanediol (1000 nM) was used. Ziram competitively inhibited SRD5A1 and non-competitively inhibited AKR1C14 when steroid substrates were used. Docking study showed that ziram bound to NADPH-binding pocket of AKR1C14. In conclusion, our results demonstrated that ziram inhibited SRD5A1 and AKR1C14 activities, thus possibly interfering with neurosteroid production in rats.
Risk factors for motorcycle loss-of-control crashes
Creators: name: Wu, Dan
name: Hours, Martine
name: Martin, Jean-Louis
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Objective: The present article identifies and assesses the effect of critical factors on the risk of motorcycle loss-of-control (LOC) crashes. Method: Data come from a French project on road crashes, which include all fatal road crashes and a random sample of 1/20th of nonfatal crashes in France in 2011, based on police reports. A case–control study was carried out on a sample of 903 crashes for 444 LOC motorcycle riders (case) and 470 non-LOC and nonresponsible motorcycle riders (control). The sample was weighted due to the randomization of nonfatal crashes. Missing values were imputed using multiple imputation. Results: Road alignment and surface conditions, human factors, and motorcycle type played important roles in motorcycle LOC crashes. Riding in a curve was associated with a 3-fold greater risk of losing control of motorcycle than riding in a straight line. Poor road adhesion significantly increased the risk of losing control; the risk increased more than 20-fold when deteriorated road adhesion was encountered unexpectedly, due to loose gravel, ice, oil, bumps, road marking, metal plates, etc. For motorcyclists, riding with a positive blood alcohol concentration (over or equal to the legal limit of 0.5 g/L) was very dangerous, often resulting in losing control. The risk of LOC crash varied for different types of motorcycle: Riders of roadsters and sports bikes were more likely to have an LOC crash greater than that of riders of basic or touring motorcycles. In addition, LOC risk increased with speed; a model using the square of the traveling speed showed better fit than one using speed itself. Conclusion: The LOC crash factors related to riders, vehicles, and road infrastructure identified here were expected but were rarely identified and taken simultaneously into account in previous studies. They could be targeted by countermeasures to improve motorcyclist safety.
Resveratrol ameliorates ionizing irradiation-induced long-term immunosuppression in mice
Creators: name: Zhang, Heng
name: Yan, Hao
name: Ying, Jianzi
name: Du, Liqing
name: Zhang, Chunze
name: Yang, Yiling
name: Wang, Huaqing
name: Wang, Hui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Purpose: Ionizing radiation has been associated with adverse effects on the immune system. Currently, there are no effective treatment options to ameliorate these effects. The aim of the present study was to investigate the protective effects of resveratrol against radiation-induced long-term immunosuppression in mice. Materials and methods: Mice were exposed to total body irradiation and treated with resveratrol or vehicle. Several immune parameters were measured, including thymus and spleen weights, T-lymphocyte and B-lymphocyte count in peripheral blood, concanavalin A and lipopolysaccharide induced lymphocyte proliferation. To explore the mechanism, we investigated intracellular ROS level of lymphocytes and mice plasma cytokine levels. Results: Treatment with resveratrol ameliorated TBI-induced atrophy of the thymus and spleen, reduction of lymphocyte count and decline of lymphocyte proliferation. TBI exhibited significantly reduced level of IL-2, IL-4, IL-7 and IFN-γ compared with the control mice and treatment with resveratrol attenuated the reduction. Conclusion: The results of the present study suggest that treatment with resveratrol could ameliorate irradiation induced long-term immune malfunction at least partly via modulation of plasma cytokine.
Resveratrol Ameliorates Ionizing Irradiation-induced Long-term Immunosuppression in Mice
Creators: name: Zhang, Heng
name: Yan, Hao
name: Ying, Jianzi
name: Du, Liqing
name: Zhang, Chunze
name: Yang, Yiling
name: Wang, Huaqing
name: Wang, Hui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Purpose- Ionizing radiation has been associated with adverse effects on the immune system. Currently, there are no effective treatment options to ameliorate these effects. The aim of the present study was to investigate the protective effects of resveratrol against radiation-induced long term immunosuppression in mice. Materials and methods- Mice were exposed to total body irradiation, and treated with resveratrol or vehicle. Several immune parameters were measured, including thymus and spleen weights, T lymphocyte and B lymphocyte count in peripheral blood, concanavalin A and lipopolysaccharide induced lymphocyte proliferation. To explore the mechanism, we investigated intracellular ROS level of lymphocytes and mice plasma cytokine levels. Results- Treatment with resveratrol ameliorated TBI-induced atrophy of the thymus and spleen, reduction of lymphocyte count, and decline of lymphocyte proliferation. TBI exhibited significantly reduced level of IL-2, IL-4, IL-7, and IFN-γ compared with the control mice, and treatment with resveratrol attenuated the reduction. Conclusion- The results of the present study suggest that treatment with resveratrol could ameliorate irradiation induced long term immune malfunction at least partly via modulation of plasma cytokine.
Theoretical investigation of electronic, vibrational, and nonlinear optical properties of 4-fluoro-4-hydroxybenzophenone
Creators: name: Pegu, David
name: Jyotirmoy Deb
name: Alsenoy, Christian Van
name: Sarkar, Utpal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: Computational Biology

description: The present study emphasizes on structural, opto-electronic, vibrational, and nonlinear properties, at the electronic structure level, on the 4-fluoro-4-hydoxybenzophenone molecule using the first principles calculation. Detailed vibrational assignments of the wavenumbers are carried out on the basis of potential energy distribution and a good agreement between the reported and calculated wavenumbers has been observed. Furthermore, the molecular electrostatic potential surface predicts the reactive site of the molecule. From the time dependent density functional theory analysis of UV-visible spectra, a red shift has been observed at the maximum absorption wavelength when the gaseous medium is replaced by a solvent medium. The 4-fluoro-4-hydroxybenzophenone molecule possesses large hyperpolarizability value which implies its usefulness in nonlinear optical applications.
Theoretical Investigation of Electronic, Vibrational and Nonlinear Optical Properties of 4-fluoro-4-hydroxybenzophenone
Creators: name: Pegu, David
name: Jyotirmoy Deb
name: Alsenoy, Christian Van
name: Sarkar, Utpal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The present study emphasizes on structural, opto-electronic, vibrational and non-linear properties, at electronic structure level, on 4-fluoro-4-hydoxybenzophenone molecule using the first principle calculation. Detailed vibrational assignments of the wavenumbers are carried out on the basis of potential energy distribution and a good agreement between the reported and calculated wavenumber has been observed. Further, molecular electrostatic potential surface predicts the reactive site of the molecule. From the time dependent density functional theory analysis on UV-visible spectra, a red shift has been observed on maximum absorption wavelength when gaseous medium is replaced by solvent medium. The nonlinear optical property of the 4-fluoro-4-hydroxybenzophenone molecule shows that this molecule possesses large nonlinear optical properties which might make it useful for various nonlinear optical applications.
Additional file 1: of Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke
Creators: name: Winkel, Per
name: Bath, Philip
name: Gluud, Christian
name: Lindschou, Jane
name: van der Worp, H.
name: Macleod, Malcolm
name: Szabo, Istvan
name: Durand-Zaleski, Isabelle
name: Schwab, Stefan
Publisher: name: figshare
Year: 2017
Subjects: Medicine
Pharmacology
Cancer
Science Policy

description: List of principal investigators in EuroHYP-1 and sites. (DOCX 32Â kb)
Bicknell's Thrush Mitigation Across Borders: A Strategy for Full Life-Cycle Conservation
Creators: name: Lloyd, John
name: Scarl, Judith
name: Juan-Carlos Martínez-Sánchez
name: Rimmer, Christopher C.
name: Leighlan Prout
name: Mathison, Susan
Publisher: name: figshare
Year: 2017
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences

description: This document describes a framework for offsetting impacts to Bicknell's Thrush (Catharus bicknelli) breeding habitat by implementing conservation actions on the wintering grounds.
Additional file 1: Table S1. of Does the oviparity-viviparity transition alter the partitioning of yolk in embryonic snakes?
Creators: name: Wu, Yan-Qing
name: Qu, Yan-Fu
name: Wang, Xue-Ji
name: Gao, Jian-Fang
name: Ji, Xiang
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Non-mammalian amniotes for which data on the ratio of residual yolk dry mass to total hatchling dry mass have been available. O: oviparity; V: viviparity. (DOC 155 kb)
A Test-Time Learning Approach to Reparameterize the Geophysical Inverse Problem with a Convolutional Neural Network
Creators: name: Xu, Anran
name: Heagy, Lindsey J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Geophysics (physics.geo-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Regularization is critical for solving ill-posed geophysical inverse problems. Explicit regularization is often used, but there are opportunities to explore the implicit regularization effects that are inherent in a Neural Network structure. Researchers have discovered that the Convolutional Neural Network (CNN) architecture inherently enforces a regularization that is advantageous for addressing diverse inverse problems in computer vision, including de-noising and in-painting. In this study, we examine the applicability of this implicit regularization to geophysical inversions. The CNN maps an arbitrary vector to the model space. The predicted subsurface model is then fed into a forward numerical simulation to generate corresponding predicted measurements. Subsequently, the objective function value is computed by comparing these predicted measurements with the observed measurements. The backpropagation algorithm is employed to update the trainable parameters of the CNN during the inversion. Note that the CNN in our proposed method does not require training before the inversion, rather, the CNN weights are estimated in the inversion process, hence this is a test-time learning (TTL) approach. In this study, we choose to focus on the Direct Current (DC) resistivity inverse problem, which is representative of typical Tikhonov-style geophysical inversions (e.g. gravity, electromagnetic, etc.), to test our hypothesis. The experimental results demonstrate that the implicit regularization can be useful in some DC resistivity inversions. We also provide a discussion of the potential sources of this implicit regularization introduced from the CNN architecture and discuss some practical guides for applying the proposed method to other geophysical methods.
MOESM1 of Structure of a Thermobifida fusca lytic polysaccharide monooxygenase and mutagenesis of key residues
Creators: name: Kruer-Zerhusen, Nathan
name: Alahuhta, Markus
name: Lunin, Vladimir
name: Himmel, Michael
name: Bomble, Yannick
name: Wilson, David
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 1: Figure S1. HPLC chromatograms of the full range of glucose gluconolactone ratios A) that demonstrate sample neutral/oxidized product ratio using B) linear standard curves for neutral and C1 oxidized monosaccharides for quantification of LPMO products.
Additional file 1: Table S1. of Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies
Creators: name: Shang, Weifeng
name: Li, Yuanyuan
name: Ren, Yali
name: Yang, Yi
name: Li, Hua
name: Dong, Junwu
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement scores of the included published studies. (DOCX 17Â kb)
Impact of postoperative pulmonary hypertension on outcome after heart transplantation
Creators: name: Lundgren, Jakob
name: Söderlund, Carl
name: Rådegran, Göran
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: We wanted to investigate the effects of postoperative pulmonary hypertension (PHpostop: mean pulmonary artery pressure [MPAP] ≥ 25 mmHg), diastolic pressure gradient (DPG), pulmonary vascular resistance (PVR), and repeated hemodynamic measurements on long-term survival after heart transplantation (HT). Design: Eighty-nine patients who underwent HT at Skåne University Hospital in Lund in the period 1988–2010 and who were evaluated with right-heart-catheterization at rest, prior to HT and repeatedly during the first postoperative year, were grouped based on their MPAP, DPG, and PVR. Results: One year after HT, survival was lower in patients with PHpostop than in those without, in patients with DPG ≥7 mmHg than in those with DPG <7 mmHg, and in patients with PVR >3 WU than in those with PVR ≤3 WU. Moreover, compared to patients with no PHpostop or with PHpostop at one evaluation during the first year after HT, PHpostop at repeated evaluations was associated with higher mortality (hazard ratio 3.4, 95% CI 1.4–8.0). There was no significant difference in acute cellular rejection between patients with and without PHpostop, but postoperative kidney function was worse in patients with repeated PHpostop. Conclusions: When defined according to present guidelines, PH one year after HT may emerge as a prognostic marker for long-term outcome after HT. Moreover, PHpostop at repeated evaluations during the first year after HT had stronger prognostic value than PHpostop at a single examination, illustrating a means of identifying a high-risk population. However, confirmation in larger multi-center studies is warranted.
MOESM1 of Agronomic performance of Populus deltoides trees engineered for biofuel production
Creators: name: Macaya-Sanz, David
name: Chen, JinâGui
name: Kalluri, Udaya
name: Muchero, Wellington
name: Tschaplinski, Timothy
name: Gunter, Lee
name: Simon, Sandra
name: Biswal, Ajaya
name: Bryan, Anthony
name: Payyavula, Raja
name: Xie, Meng
name: Yang, Yongil
name: Zhang, Jin
name: Mohnen, Debra
name: Tuskan, Gerald
name: DiFazio, Stephen
Publisher: name: figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: Developmental Biology
subject: Plant Biology

description: Additional file 1. Heatmaps for trait predicted values on each of the coordinates of the trial using a thin-plate spline correction model. Note that the color scale ranges from twice the standard deviation over the mean of the trait observed values to twice the standard deviation below the mean, to reflect the proportion of trait variance accounted for by the model. Traits represented are (A) internode length, (B) height growth, (C) quadratic mean diameter, (D) volume index, (E) height to first branch, (F) number of branches, (G) stem sinuosity, (H) stem length-height ratio, (I) apical index, (J) trunk section eccentricity, (K) bud set, (L) bud flush, (M) frost damage, (N) Melampsora severity, and (O) overall herbivory.
MOESM1 of CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling
Creators: name: Xu, Gang
name: Dang, Chengxue
Publisher: name: figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Primers used in this study.
Additional file 2: Table S2. of Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies
Creators: name: Shang, Weifeng
name: Li, Yuanyuan
name: Ren, Yali
name: Yang, Yi
name: Li, Hua
name: Dong, Junwu
Publisher: name: figshare
Year: 2017
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Sensitivity analysis. (DOC 28Â kb)
Identifying Factors Affecting the Safety of Mid-block Bicycle Lanes Considering Mixed Two-wheeled Traffic Flow
Creators: name: Bai, Lu
name: Ching-Yao Chan
name: Liu, Pan
name: Chengcheng Xu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Objective: Electric bikes (e-bikes) were one of the fastest growing trip modes in Southeast Asia over the past two decades. The increasing popularity of e-bikes raised some safety concerns on urban transport system. The primary objective of this study was to identify whether and how the generalized linear regression model (GLM) could be used to relate the cyclists' safety with various contributing factors when they were riding in a mid-block bike lane. The types of two-wheeled vehicles in the study included bicycle style electric bicycles (BSEBs), scooter style electric bicycles (SSEBs) and regular bicycles (RBs). Methods: Traffic conflict technology was applied as a surrogate measures for evaluating the safety of two-wheeled vehicles. The safety performance model was developed by adopting a generalized linear regression model for relating the frequency of rear-end conflicts between e-bikes and regular bikes to the operating speeds of BSEBs, SSEBs and RBs in mid-block bike lanes. Results: The frequency of rear-end conflicts between e-bikes and bikes increased with an increase in the operating speeds of e-bikes and the volume of e-bikes and bikes, while decreased with an increase in the width of bike lanes. Large speed difference between e-bikes and bikes increased the frequency of rear-end conflicts between e-bikes and bikes in mid-block bike lanes. One percent increase in the average operating speed of e-bikes would increase the expected number of rear-end conflicts between e-bikes and bikes by 1.48%. One percent increase in the speed difference of e-bikes and bikes would increase the expected number of rear-end conflicts between e-bikes/bikes by 0.16%. Conclusions: The conflict frequency in mid-block bike lanes can be modeled using generalized linear regression models. The factors that significantly affected the frequency of rear-end conflicts included the operating speeds of e-bikes, the speed difference of the e-bikes and regular bikes, the volume of e-bikes, the volume of bikes and the width of bike lanes. The safety performance model can help better understand the causes of crash occurrences in mid-block bike lanes.
MOESM2 of Agronomic performance of Populus deltoides trees engineered for biofuel production
Creators: name: Macaya-Sanz, David
name: Chen, Jin‐Gui
name: Kalluri, Udaya
name: Muchero, Wellington
name: Tschaplinski, Timothy
name: Gunter, Lee
name: Simon, Sandra
name: Biswal, Ajaya
name: Bryan, Anthony
name: Payyavula, Raja
name: Xie, Meng
name: Yang, Yongil
name: Zhang, Jin
name: Mohnen, Debra
name: Tuskan, Gerald
name: DiFazio, Stephen
Publisher: name: figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Plant Biology

description: Additional file 2. Bar plots of several measured traits after TPS correction. Bars correspond to a random subsample of empty-vector trees (very light grey), the wild type (light grey), and the 29 transgenic lines grouped by genes. Dark grey indicates Comparator lines and very dark grey indicates TOP lines. Error bars represent 95% confidence intervals. Asterisks indicate Tukey’s HSD mean difference significance (α = 0.05) between the marked transgenic line and the empty-vector control. Traits depicted are (A) total height, (B) quadratic mean diameter, (C) height to first branch, (D) number of branches, (E) stem sinuosity, (F) stem length-height ratio, (G) apical index, (H) trunk section eccentricity, (I) bud set, (J) frost damage, (K) Melampsora severity, (L) overall herbivory, and (M) twig borer incidence.
REACT Statistical Analysis Plan v1.0; An online randomised controlled trial to evaluate the clinical and cost effectiveness of a peer supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit (REACT)
Creators: name: Dodd, Susanna
Publisher: name: figshare
Year: 2017
Subjects: subject: 111707 Family Care
subject: FOS: Health sciences
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: This document outlines in detail the statistical analysis plan for data collected during the REACT trial
Identifying factors affecting the safety of mid-block bicycle lanes considering mixed 2-wheeled traffic flow
Creators: name: Bai, Lu
name: Ching-Yao Chan
name: Liu, Pan
name: Chengcheng Xu
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Objective: Electric bikes (e-bikes) have been one of the fastest growing trip modes in Southeast Asia over the past 2 decades. The increasing popularity of e-bikes raised some safety concerns regarding urban transport systems. The primary objective of this study was to identify whether and how the generalized linear regression model (GLM) could be used to relate cyclists' safety with various contributing factors when riding in a mid-block bike lane. The types of 2-wheeled vehicles in the study included bicycle-style electric bicycles (BSEBs), scooter-style electric bicycles (SSEBs), and regular bicycles (RBs). Methods: Traffic conflict technology was applied as a surrogate measure to evaluate the safety of 2-wheeled vehicles. The safety performance model was developed by adopting a generalized linear regression model for relating the frequency of rear-end conflicts between e-bikes and regular bikes to the operating speeds of BSEBs, SSEBs, and RBs in mid-block bike lanes. Results: The frequency of rear-end conflicts between e-bikes and bikes increased with an increase in the operating speeds of e-bikes and the volume of e-bikes and bikes and decreased with an increase in the width of bike lanes. The large speed difference between e-bikes and bikes increased the frequency of rear-end conflicts between e-bikes and bikes in mid-block bike lanes. A 1% increase in the average operating speed of e-bikes would increase the expected number of rear-end conflicts between e-bikes and bikes by 1.48%. A 1% increase in the speed difference between e-bikes and bikes would increase the expected number of rear-end conflicts between e-bikes/bikes by 0.16%. Conclusions: The conflict frequency in mid-block bike lanes can be modeled using generalized linear regression models. The factors that significantly affected the frequency of rear-end conflicts included the operating speeds of e-bikes, the speed difference between e-bikes and regular bikes, the volume of e-bikes, the volume of bikes, and the width of bike lanes. The safety performance model can help better understand the causes of crash occurrences in mid-block bike lanes.
Data and Results (CREP #23-09)
Creators: name: Salvayre, Hugo
name: Gourdon-Kanhukamwe, Amélie
name: Jahier Léna
name: Maxyme Gallo
name: Bernard, Chloé
Publisher: name: OSF Registries
Year: 2020
Subjects: CREP

description: All the data and results we have collected are compiled here
Identifying factors affecting the safety of mid-block bicycle lanes considering mixed 2-wheeled traffic flow
Creators: name: Bai, Lu
name: Ching-Yao Chan
name: Liu, Pan
name: Chengcheng Xu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Objective: Electric bikes (e-bikes) have been one of the fastest growing trip modes in Southeast Asia over the past 2 decades. The increasing popularity of e-bikes raised some safety concerns regarding urban transport systems. The primary objective of this study was to identify whether and how the generalized linear regression model (GLM) could be used to relate cyclists' safety with various contributing factors when riding in a mid-block bike lane. The types of 2-wheeled vehicles in the study included bicycle-style electric bicycles (BSEBs), scooter-style electric bicycles (SSEBs), and regular bicycles (RBs). Methods: Traffic conflict technology was applied as a surrogate measure to evaluate the safety of 2-wheeled vehicles. The safety performance model was developed by adopting a generalized linear regression model for relating the frequency of rear-end conflicts between e-bikes and regular bikes to the operating speeds of BSEBs, SSEBs, and RBs in mid-block bike lanes. Results: The frequency of rear-end conflicts between e-bikes and bikes increased with an increase in the operating speeds of e-bikes and the volume of e-bikes and bikes and decreased with an increase in the width of bike lanes. The large speed difference between e-bikes and bikes increased the frequency of rear-end conflicts between e-bikes and bikes in mid-block bike lanes. A 1% increase in the average operating speed of e-bikes would increase the expected number of rear-end conflicts between e-bikes and bikes by 1.48%. A 1% increase in the speed difference between e-bikes and bikes would increase the expected number of rear-end conflicts between e-bikes/bikes by 0.16%. Conclusions: The conflict frequency in mid-block bike lanes can be modeled using generalized linear regression models. The factors that significantly affected the frequency of rear-end conflicts included the operating speeds of e-bikes, the speed difference between e-bikes and regular bikes, the volume of e-bikes, the volume of bikes, and the width of bike lanes. The safety performance model can help better understand the causes of crash occurrences in mid-block bike lanes.
Ethics Approval (CREP #23-09)
Creators: name: Gourdon-Kanhukamwe, Amélie
name: Salvayre, Hugo
name: Jahier Léna
name: Maxyme Gallo
name: Bernard, Chloé
Publisher: name: OSF Registries
Year: 2020
Subjects: CREP

description: Here is the consent form that we use to distribute our study in french and english.
MOESM1 of Dynamic changes in transcriptome and cell wall composition underlying brassinosteroid-mediated lignification of switchgrass suspension cells
Creators: name: Rao, Xiaolan
name: Shen, Hui
name: Pattathil, Sivakumar
name: Hahn, Michael
name: Gelineo-Albersheim, Ivana
name: Mohnen, Debra
name: Pu, Yunqiao
name: Ragauskas, Arthur
name: Chen, Xin
name: Chen, Fang
name: Dixon, Richard
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Additional file 1: Figure S1. Comparison of the monosaccharide composition of switchgrass suspension cell walls with those of other plant cell suspensions. Figure S2. Glycome profiling heat map showing the relative abundance of cell wall glycan epitopes released sequentially from the AIR fractions of non-induced and BL-induced suspension cells. Figure S3. Measurement of wall-bound phenolic acids in non-induced and BL-induced switchgrass suspension culture cells. Figure S4. Principal component analysis (PCA) of genes expressed in BL-induced cultures. Figure S5. The expression of CESA genes in non-induced and BL-induced cultures. Figure S6. Validation of cell wall-related gene expression in switchgrass suspension cultures by qRT-PCR. Figure S7. Overview of changes in transcript levels for genes involved in cell wall precursor synthesis in BL-induced cultures. Figure S8. Proposed route for S lignin biosynthesis in BL-induced suspension cells.
Predictive parameters for imatinib failure in patients with chronic myeloid leukemia
Creators: name: Lekovic, Danijela
name: Gotic, Mirjana
name: Natasa Milic
name: Zivojinovic, Biljana
name: Jovanovic, Jelica
name: Natasa Colovic
name: Milosevic, Violeta
name: Bogdanovic, Andrija
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objective: Until recently, imatinib was the standard first-line treatment in chronic myeloid leukemia (CML). The inclusion of nilotinib and dasatinib as first-line options in CML raised a debate on treatment selection. The aim of our study was to analyze predictive parameters for imatinib response as the first-line treatment of CML patients. Methods: The study included 168 consecutive patients with chronic phase Philadelphia-positive CML who were diagnosed and treated with Imatinib 400 mg once daily at a single university hospital. Numerous parameters were analyzed in terms of imatinib response including comorbidities as well as occurrence of second malignancies. Results: After the median follow-up of 87 months in 61 patients (36.3%), the imatinib failure was verified. Cox regression analysis identified hepatomegaly (p = 0.001), leukocytosis ≥ 100 × 109/l (p = 0.001), blood blasts ≥ 1% (p = 0.002), and the presence of additional cytogenetic aberrations (p = 0.002) as predictors of Imatinib failure. Based on these findings, a new prognostic model was developed according to which imatinib failure had 17% (8/47) of patients in low risk, 34.9% (30/86) of patients in intermediate risk, and 76.7% (23/30) of patients in high-risk group (HR = 3.973, 95% CI for HR 2.237–7.053, p Conclusion: The new score allows better selection of patients who are suitable for treatment with imatinib and may guideline the clinical decision for front-line treatment of CML.
REACT Statistical Analysis Plan v1.0; An online randomised controlled trial to evaluate the clinical and cost effectiveness of a peer supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit (REACT)
Creators: name: Lobban, Fiona
Publisher: name: figshare
Year: 2017
Subjects: subject: 111707 Family Care
subject: FOS: Health sciences
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: This document outlines in detail the statistical analysis plan for data collected during the REACT trial
Natural volume forms on pseudo-Finslerian manifolds with $m$-th root metrics
Creators: name: Solov'yov, Anton V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We define natural volume forms on $n$-dimensional oriented pseudo-Finslerian manifolds with non-degenerate $m$-th root metrics. Our definitions of the natural volume forms depend on the parity of the positive integer $m>1$. The advantage of the stated definitions is their algebraic structure. The natural volume forms are expressed in terms of Cayley hyperdeterminants. In particular, the computation of the natural volume form does not require the difficult integration over the domain within the indicatrix in the tangent space $T_x M^n$ of the pseudo-Finslerian manifold at a point $x$.
description: LaTeX, 14 pages, minor corrections
Stonebrood and chalkbrood in Apis mellifera causing fungi: in vitro sensitivity to some essential oils
Creators: name: Nardoni, Simona
name: D’Ascenzi, Carlo
name: Rocchigiani, Guido
name: Papini, Roberto Amerigo
name: Pistelli, Luisa
name: Formato, Giovanni
name: Najar, Basma
name: Mancianti, Francesca
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Aim of the present study was to evaluate the in vitro antimycotic activity of 17 chemically defined essential oils (EOs) both alone and as a mixture, against agents responsible for stonebrood caused by Aspergillus flavus, and chalkbrood caused by Ascosphaera apis in European honeybees. Cinnamomum zeylanicum yielded the lowest MIC value against A. flavus, but was not effective against A. apis, while Litsea cubeba and Pelargonium graveolens appeared to be effective against all checked fungi. Aspergillus niger showed the lower sensitivity. Two mixtures composed by L. cubeba, C. zeylanicum and Cymbopogon flexuosus (M1) and by L. cubeba, C. zeylanicum, P. graveolens and C. flexuosus (M2), respectively, were tested, both resulting effective. The components of M1 showed a synergistic effect. The use of mixtures allowed to decrease the total amount of EOs. The use of these products could be of interest for an alternative natural approach in honeybee disease management.
MOESM2 of Dynamic changes in transcriptome and cell wall composition underlying brassinosteroid-mediated lignification of switchgrass suspension cells
Creators: name: Rao, Xiaolan
name: Shen, Hui
name: Pattathil, Sivakumar
name: Hahn, Michael
name: Gelineo-Albersheim, Ivana
name: Mohnen, Debra
name: Pu, Yunqiao
name: Ragauskas, Arthur
name: Chen, Xin
name: Chen, Fang
name: Dixon, Richard
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Materials and Methods. Supplementary information on pre-processing of the microarray dataset.
National mitigation potential from natural climate solutions in the tropics.
Creators: name: Griscom, Bronson W
name: Busch, Jonah
name: Cook-Patton, Susan C
name: Ellis, Peter W
name: Funk, Jason
name: Leavitt, Sara M
name: Lomax, Guy
name: Turner, Will R
name: Chapman, Melissa
name: Engelmann, Jens
name: Gurwick, Noel P
name: Landis, Emily
name: Lawrence, Deborah
name: Malhi, Yadvinder
name: Schindler Murray, Lisa
name: Navarrete, Diego
name: Roe, Stephanie
name: Scull, Sabrina
name: Smith, Pete
name: Streck, Charlotte
name: Walker, Wayne S
name: Worthington, Thomas
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Protection
Restoration
Climate Mitigation
Land Management
Paris Agreement
Natural Climate Solutions

description: Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2°C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO2e yr-1 at less than 100 US$ per Mg CO2e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'.
Multivariate Analysis for Scanning (Transmission) Electron Diffraction
Creators: name: Martineau, Benjamin Helks
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: machine learning
electron microscopy
multivariate analysis
data clustering
fuzzy logic
unsupervised learning
transmission electron microscopy
scanning electron microscopy
tazewell

description: Scanning electron microscopy (SEM) and scanning transmission electron microscopy (STEM) are powerful and versatile techniques for materials science research. The technologies of beam control, aberration correction, signal collection, and data processing have all improved in recent years, leading to a move away from the acquisition single-variable images. Instead it is increasingly common, in the field of analytical S(T)EM, for whole energy spectra to be collected for post-facto compositional analysis. The development of scanning precession electron diffraction (SPED) has enabled the rise of post-facto crystallographic investigation, but the associated analysis techniques remain relatively undeveloped. This research presents several novel applications of the family of computational methods known as multivariate statistics to SPED and SEM data. Two methods - linear decomposition and data clustering - are investigated in detail using model, simulated, and experimental SPED data. The investigation focuses on the practical aspects of analysis - the microstructural information that can be extracted, and the artefacts that can be produced. In particular, it is demonstrated that linear decomposition produces a representation of the data that can be linked directly to microstructure, and analysed using data clustering. Using these methods, the ``cloudy zone'', a complex two-phase microstructure present in iron-nickel meteorites, is investigated, resulting in the first direct observation of the crystallography of one of the phases, and providing a preliminary indication of the relationship between crystal structure and magnetic state of this material. Shifting focus to SEM data, density-based clustering is applied - for the first time - to indexed electron back-scatter diffraction (EBSD) orientation data, and shown to be an ideal algorithm. The novel use of data clustering in the context of misorientation data is also presented, opening up the possibility for semi-automated crystallographic habit determination. Finally, the application of multivariate analysis to combined EDS and EBSD data is investigated to assess the potential for quantifiable correlated structural and compositional analysis.
description: Funded by the Royal Society
Evaluation of antibacterial activity of the bark and leaf extracts of Brosimum gaudichaudii Trécul against multidrug resistant strains
Creators: name: Borges, Joelma Da Costa
name: Perim, Michele Cezimbra
name: Castro, Rodrigo Orlandini De
name: Thiago Antônio De Sousa Araújo
name: Tadeu José Da Silva Peixoto Sobrinho
name: Silva, Ana Carolina Oliveira Da
name: Mariano, Sandra Maria Botelho
name: Carreiro, Solange Cristina
name: Pranchevicius, Maria Cristina Da Silva
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Brosimum gaudichaudii Trécul., a plant that belongs to Moraceae family, is found throughout the Brazilian Cerrado. The antimicrobial activities of ethanolic bark and leaf extracts of B. gaudichaudii were tested against multiresistant bacteria isolated from diabetic foot infections (DFIs). Antimicrobial activity of the extracts was evaluated by agar disc diffusion (DD) and broth dilution (BD) methods. By BD method, bark (53.85, 45.83%) and leaf (42.31, 50.00%) extracts contained antimicrobial activity against both gram-negative and gram-positive bacteria. Increased antimicrobial activity was observed when bark and leaf extracts were tested against Staphylococcus aureus (63.64%) and Pseudomonas aeruginosa (66.67%). Statistical analyses of bark and leaf extract demonstrated antimicrobial activity against both gram-positive (p = 0.000) and gram-negative bacteria (p = 0.012). Extract of bark (p = 0.075) or leaf (p = 0.005) associated with ACA antibiotic showed antimicrobial activity against gram-positive bacteria. Our study suggests that the bark and leaf extracts contain bioactive compounds with antimicrobial activity against multidrug resistant strains.