cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Utilizing Metabolic Engineering Tools and Developing Multiplex CRISPR-Cas9 to Produce High-Value Plant Metabolites in Saccharomyces cerevisiae
Creators: name: Utomo, Joseph C.
Publisher: name: Science
Year: 2023
Subjects: subject: Metabolic engineering
subject: mulitplex CRISPR-Cas9
subject: plant natural products
subject: Saccharomyces cerevisiae
subject: Biology--Molecular
subject: Chemistry--Biochemistry

description: Plants produce a vast array of valuable natural products but often in extremely low quantities. The emergence of diverse metabolic engineering tools has provided the means to re-wire microbe’s metabolic pathways, enabling the overproduction of complex natural products efficiently. Likewise, the development of the CRISPR-Cas9 system has simplified genome editing in the model yeast S. cerevisiae. One application of CRISPR-Cas9 in yeast is multiplex gene integration – the integration of multiple genes into the genome. In this work, three studies on the production of high-value plant natural products in yeast using diverse combinations of metabolic engineering tools and multiplex gene integration will be demonstrated.First, a yeast strain capable of producing taxadiene, a critical precursor of taxol – a potent anticancer drug – was created using metabolic engineering strategies and CRISPR-Cas9-mediated gene integration. The resulting strain produced a relatively high titer of taxadiene without plasmids or marker genes. This offers a valuable tool to elucidate the taxol biosynthetic pathway.Next, a multiplex gene integration in yeast was optimized. From our previous study, a yeast multiplex gene integration platform, called SGM-CRISPR, was developed. Here, the platform was expanded to integrate six genes in a single transformation. Using bi-directional promoters, the successful integration of eight genes into the yeast genome in a single transformation was also demonstrated. The development of this platform provides a powerful tool to quickly integrate plant metabolic pathways in yeast.Finally, the metabolic efficiency of three distinct phenylpropanoid pathways was compared using curcumin as a readout product. To accomplish this, the three pathways were integrated into the yeast genome within two weeks using a modified version of the SGM-CRISPR platform. To improve the titer of curcumin, an endogenous yeast enzyme, which reduces the key intermediates in the pathway, was substituted with a complementary apple enzyme, resulting in a drastic improvement of the curcumin titer. One of the non-traditional phenylpropanoid pathways demonstrated a higher efficiency of curcumin production than the traditional pathway. This work was the first de novo biosynthesis of curcumin, in yeast with a titer of 3.1 mg/L.
Equine Exercise Physiology: Cardiovascular Responses to Exercise and Training
Creators: name: Israel, Julia
Publisher: name: Veterinary Medicine
Year: 2022
Subjects: subject: Equine
subject: horses
subject: cardiology
subject: respiratory
subject: blood volume
subject: splenic contraction
subject: plasma volume
subject: physiology
subject: Biological Sciences

description: The horse is a fantastic athlete with unique adaptations in response to the requirements associated with exercise. Exercise induces a great increase in minute ventilation through increases in tidal volume and breathing frequency. Despite the great lung capacity of horses, the main limitation to performance remains ventilation. The cardiovascular system will provide the link between pulmonary ventilation and oxygen delivery within the cells. During exercise, efficient delivery of oxygen to the working skeletal and cardiac muscles is needed for ATP production during the aerobic mechanisms. The equine cardiovascular system has specific adaptations that will fulfill the high need for oxygen delivery during exercise, increasing oxygen uptake >35 times over resting conditions. The cardiorespiratory physiology among equine athletes is complex, and the aim of chapter one is to review and introduce the main aspects of the equine exercise physiology focused on the cardiorespiratory system and its adaptations to exercise. One important adaptation to exercise in horses is their great exercise-induced splenic contraction. This splenic contraction increases the amount of circulating red blood cells and, by extension, hemoglobin during exercise. This extrusion of red blood cells will alter the intravascular red cell mass, and almost double the venous hematocrit, enhancing cardiac output and oxygen-carrying capacity during exercise.Measurement of the effect of splenic contraction on plasma volume (PV) and blood volume (BV) changes is however challenging. For example, BV might vary with work intensity, sex, age, and state of training. In addition, the fluid shifts between body fluid compartments can also affect the values, decreasing or increasing the PV depending on the type of exercise and duration. The PV can be measured using different techniques that will be further discussed; however, it is also a difficult technique. Training is key to preparing the equine athletes for competitions; however, it is still often done empirically since the documentation of the effects of training on the equine exercise physiology is scarce. Furthermore, equestrian competitions have specific metabolic requirements, with endurance racing being the most aerobic performance, whereas Thoroughbred racing focuses on high speed over a few minutes.
Chiara Cappelletto, Neuroestetica. L'arte del cervello.
Creators: name: Franzini, Elio
Publisher: name: Università degli  Studi di Milano
Year: 2010

description: Chiara Cappelletto, Neuroestetica.
L'arte del cervello.
(Roma-Bari, Laterza, 2009, pp. 203, ISBN - 9788842088998)
di Elio Franzini
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
Exploring Children’s Constructions of Risk, Risky Play, Injury, and Pain: A Qualitative Case Study
Creators: name: McCallum, Kyle S
Publisher: name: Kinesiology
Year: 2022
Subjects: subject: Risk
subject: Risky Play
subject: Outdoor Education
subject: Children
subject: Youth
subject: Injury Knowledge
subject: Risk Knowledge
subject: Sociocultural
subject: Qualitative
subject: Education--Elementary
subject: Health Sciences--Epidemiology
subject: Sociology--General

description: Challenges and risk-taking in play and physical activity can contribute positively to children’s growth and development. However, mounting anxieties related to children’s welfare and safety have resulted in several types of risks being minimized or removed. While a body of knowledge focused on risk and childhood physical activity—i.e., risky play—has emerged, there remains a paucity of literature that foregrounds children’s knowledge and experiences specifically. In this dissertation, I focus on children’s constructions of risk, risky play, pain, and injury in effort to strengthen our knowledge about these social phenomena. Adopting social constructionism as my philosophical underpinning, I conducted a meta-study in which I reviewed 22 studies focused on children’s knowledge and experiences of risk, risky play, and injury to understand what was known and what gaps may still exist. The findings from my meta-study then informed the first interview guide of my main study. I interviewed 22-students participating in an outdoor education program at a local charter academy in Calgary, Alberta, Canada. Student participants were interviewed twice. The first set of interviews explored constructions and experiences related to risk, risky play, pain, and injury. The second set of interviews expanded on ideas that emerged that emerged from the first set of interviews, including ideas related to social risk, independence and autonomy, and common sense, while also exploring how risk was presented and experienced through the outdoor education program. While participants constructed risk and risky play in similar ways as adults, they also normalized injury as being a primary outcome when engaging in risk, creating paradoxical messaging between their desires for greater risk experiences while conceptualizing outcomes as being injurious in nature. Participants also identified risk as being an important part of their growth and development, stating that risk was viewed as a metric of maturation, trust, and greater autonomy. Lastly, participants referenced multiple safety measures set for them in relation to risk-taking and risk-management. Insights gained from the participants demonstrated that they understood and accepted risk, but also highlighted worrisome gaps in their risk knowledge, specifically related to negative, and often extreme, outcomes. Findings of this dissertation can help strengthen our knowledge about risk-taking and risk-management in childhood play and physical activity experiences.
Model-independent extraction of $|V_{tq}|$ matrix elements from top-quark measurements at hadron colliders
Creators: name: Lacker, H.
name: Menzel, A.
name: Spettel, F.
name: Hirschbühl, D.
name: Lück, J.
name: Maltoni, F.
name: Wagner, W.
name: Zaro, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Current methods to extract the quark-mixing matrix element $|V_{tb}|$ from single-top production measurements assume that $|V_{tb}|\gg |V_{td}|, |V_{ts}|$: top quarks decay into $b$ quarks with 100% branching fraction, s-channel single-top production is always accompanied by a $b$ quark and initial-state contributions from $d$ and $s$ quarks in the $t$-channel production of single top quarks are neglected. Triggered by a recent measurement of the ratio $R=\frac{|V_{tb}|^{2}}{|V_{td}|^{2}+|V_{ts}|^{2}+|V_{tb}|^{2}}=0.90 \pm 0.04$ performed by the D0 collaboration, we consider a $|V_{tb}|$ extraction method that takes into account non zero d- and s-quark contributions both in production and decay. We propose a strategy that allows to extract consistently and in a model-independent way the quark mixing matrix elements $|V_{td}|$, $|V_{ts}|$, and $|V_{tb}|$ from the measurement of $R$ and from single-top measured event yields. As an illustration, we apply our method to the Tevatron data using a CDF analysis of the measured single-top event yield with two jets in the final state one of which is identified as a $b$-quark jet. We constrain the $|V_{tq}|$ matrix elements within a four-generation scenario by combining the results with those obtained from direct measurements in flavor physics and determine the preferred range for the top-quark decay width within different scenarios.
description: 36 pages, 17 figures
IOT Based Eye Blink Detection App and Hardware
Creators: name: Piyusha S. Patil, Arya V. Patil, Prajal V. Bora, Sakshi Y. Salokhe, Mr.Ranjit L. Kadam
Publisher: name: Zenodo
Year: 2025

description: This paper presents the development of an IoT-based eye blink detection system designed to assistpeople with disabilities and improve user interfaces across various applications. The system integratessensor-based hardware with cloud computing to monitor eye movements and detect blinks in real time. Thehardware setup includes a microcontroller coupled with sensors such as an IR sensor or a camera-basedsystem that tracks eye movement. The detected blink signals are wirelessly transmitted to a cloud platform forprocessing and analysis. The processed data is used to calculate blink frequency, which can then be used tocontrol different devices or trigger actions, such as operating a wheelchair or managing smart home appliances. The system also offers real-time monitoring, data storage, and user customization through a mobile app, allowing users to adjust sensitivity settings and configure triggers basedon their preferences. Moreover, this research discusses the challenges of developing a low-latency, efficient, and reliable communication system for accurate detection and control. Theresults highlight the potential of this IoT-based solution to enhance the quality of life for individuals withmobility or vision impairments, as well as improve human-computer interaction for various applications.
System level mechanisms of adaptation, learning, memory formation and evolvability: the role of chaperone and other networks
Creators: name: Gyurko, David M.
name: Soti, Csaba
name: Stetak, Attila
name: Csermely, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Biological Physics (physics.bio-ph)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here, we describe first the protein structure networks of molecular chaperones, then characterize chaperone containing sub-networks of interactomes called as chaperone-networks or chaperomes. We review the role of molecular chaperones in short-term adaptation of cellular networks in response to stress, and in long-term adaptation discussing their putative functions in the regulation of evolvability. We provide a general overview of possible network mechanisms of adaptation, learning and memory formation. We propose that changes of network rigidity play a key role in learning and memory formation processes. Flexible network topology provides "learning competent" state. Here, networks may have much less modular boundaries than locally rigid, highly modular networks, where the learnt information has already been consolidated in a memory formation process. Since modular boundaries are efficient filters of information, in the "learning competent" state information filtering may be much smaller, than after memory formation. This mechanism restricts high information transfer to the "learning competent" state. After memory formation, modular boundary-induced segregation and information filtering protect the stored information. The flexible networks of young organisms are generally in a "learning competent" state. On the contrary, locally rigid networks of old organisms have lost their "learning competent" state, but store and protect their learnt information efficiently. We anticipate that the above mechanism may operate at the level of both protein-protein interaction and neuronal networks.
description: 19 pages, 2 Figures, 1 Table, 173 references
Characterization of the A13 Region in Normal and Parkinsonian Mice
Creators: name: Kim, Linda H.
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Dopamine
subject: Connectome
subject: Parkinson’s Disease
subject: Motor
subject: Zona Incerta
subject: A13
subject: Biology--Neuroscience

description: Dopamine is an essential neurotransmitter for motor control (Sharples, Koblinger, Humphreys, & Whelan, 2014). It is most well known for its involvement in Parkinson's disease (PD); decreased levels of dopamine from the death of dopaminergic cells within the substantia nigra pars compacta are accompanied by the slowness of gait and smaller stride length (Bartels & Leenders, 2009). Dopaminergic motor drive to the spinal circuitry is indirect via ascending projections from the substantia nigra pars compacta (SNc) to the dorsal striatum that project onto the brainstem locomotor regions or the motor cortex. In addition, there is evidence for parallel direct descending dopaminergic pathways to brainstem locomotor regions and the spinal cord (Koblinger et al., 2014, 2018; Ryczko et al., 2016, 2013; Sharma et al., 2018). However, the contributions of descending dopaminergic neurons in locomotor control require further investigation.Interestingly, dopaminergic neurons in the zona incerta (ZI) which forms the A13 nucleus of ZI, are preserved in advanced human PD and animal models of PD (Matzuk & Saper, 1985; Peoples et al., 2012; Roostalu et al., 2019; Shaw et al., 2010). The A13 projects onto the mesencephalic locomotor region (MLR) (Sharma et al., 2018) providing a parallel motor pathway and an alternate source of dopamine at the MLR in PD. Yet, the A13 nucleus remains largely uncharacterized. Thus, my thesis explored the role of the A13 nucleus in locomotor control. I demonstrate that the A13 cells have two types of firing patterns with differences in intrinsic membrane properties that would integrate and propagate signals differently to support a variety of motor responses. In addition, the dopaminergic A13 cells are preserved following nigrostriatal degeneration, but the A13 connectome undergoes brain-wide remodelling, suggestive of endogenous compensatory mechanisms. Identifying the role of preserved parallel dopaminergic motor pathways is critical for understanding the heterogeneity of motor dysfunctions and developing alternate therapeutic targets for gait improvement.
La metafora e i neuroni: stato dell’arte
Creators: name: Calabrese, Stefano
Publisher: name: Università degli Studi di Milano
Year: 2012

description: La metafora costituisce un dispositivo cognitivamente complesso, basato sulla mappatura di due domini in conflitto, che si impone in tutte le dimensioni della vita quotidiana. La prospettiva neuroscientifica consente oggi di riconoscere nel pensiero metaforico non solo un attivatore della plasticità del cervello, e in quanto tale partecipe attivo della storia evolutiva della mente umana, ma un grado successivo di elaborazione cognitiva rispetto alle mappature implicite nella metonimia.
description: ENTHYMEMA, No 7 (2012)
Alex Woloch, Caratterizzazione e distribuzione
Creators: name: Zangari, Sostene Massimo
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Personaggio, romanzo, Ottocento, teoria della narrazione

description: Le opere narrative mostrano un’innata consapevolezza della tensione che deriva dalla necessità di distribuire l’attenzione su diversi personaggi in quantità disomogenee. L’autore si propone di creare un modello teorico per affrontare una serie di questioni legate alle scelte distribuzionali nel romanzo dell’Ottocento. Vengono introdotte le categorie di spazio-personaggio – l’incontro/scontro tra individuo rappresentato e spazio narrativo – e sistema-personaggi – la disposizione di personaggi multipli in una struttura narrativa. Le categorie intendono ovviare alla scissione che ha dominato la critica sul personaggio, divisa tra due posizioni antitetiche: da un lato chi ha ridotto il personaggio a mero accorgimento formale, dall’altro coloro i quali ne hanno enfatizzato l’aspetto referenziale e umano. L’intento delle categorie qui proposte è invece quello di recuperare la dialettica che lega questi due aspetti del personaggio finzionale. In particolare, mettere in evidenza come gli esiti strutturali del romanzo dipendano dal problema di rappresentare personaggi minori ridotti ai due principali paradigmi del bizzaro e del lavoratore. I meccanismi del romanzo e i disequilibri strutturali che derivano dall’incorporazione dei personaggi sono interpretati dall’autore come rispechiamento del difficile rapporto tra diseguaglianza e democrazia, che ha contrassegnato un secolo, l’Ottocento, dove alla mobilità sociale della borghesia faceva da contraltare la marginalizzazione delle classi subalterne. L’intervento si conclude con cenni al trattamento del personaggio nei lavori di Jane Austen, Dickens e Balzac.
description: ENTHYMEMA, No 7 (2012)
Veterans' experiences following the violent death of a close comrade
Creators: name: Olson, Trevor Ole
Publisher: name: University of British Columbia
Year: 2013

description: A qualitative, phenomenological research design was used to investigate the experience of coming to terms with the violent death of a comrade, for male war veterans who had participated in overseas deployments. The purpose of the study was to describe veterans’ accounts of their experiences in adjusting to, coming to terms with, and making sense of the deaths of their close comrades and friends. Eleven veterans who had experienced the death of a close comrade volunteered to describe their experiences in unstructured, in-depth, audio-taped interviews. A thematic analysis of the essential meaning structures of participants’ experiences of coming to terms with the death of their comrade by violent means, reflected their initial experience of the loss, and how they lived with, and processed the loss over time. The four themes common to their initial experience of the loss included: 1) shock, disbelief and the search for explanations; 2) helplessness, retribution and rage; 3) inhibited grief; and, 4) a sense of responsibility for the loss and for letting their friend down. The four themes common to living with and processing the loss over time included: 1) protracted and unfinished grief; 2) alienation, mistrust, and disconnection; 3) existential reflection; and 4) working through the grief and trauma. These themes were confirmed and refined through validation interviews with the participants. These findings are discussed as they relate to, and expand upon, literature related to bereavement after violent loss, homicide, and in particular, the experience of combat losses for veterans.
Voci di creature incatenate. Amelia Rosselli ascolta Ingeborg Bachmann
Creators: name: De March, Silvia
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Amelia Rosselli, Ingeborg Bachmann, poesia, autore

description: Numerose dichiarazioni di Amelia Rosselli istituiscono un rapporto saldo tra l’ultimo suo poemetto, Impromptu, edito nel 1981, e le poesie di Ingeborg Bachmann. Alla luce dei documenti conservati nel Fondo Amelia Rosselli del Centro di Tradizione Manoscritta di Pavia, analizziamo le convergenze testuali tra le due produzioni poetiche e le premesse teoriche affini. Concludiamo che l’ispirazione alla Bachmann è piuttosto labile e che di contro l’insistenza nel proclamare un’ascendenza genetica da una parte convalida una corrispondenza maggiormente retrospettiva, dall’altra rientra nella strategia di autocostruzione di una figura autoriale da parte della Rosselli.
description: ENTHYMEMA, No 7 (2012)
Euler-Mahonian Statistics via Polyhedral Geometry
Creators: name: Beck, Matthias
name: Braun, Benjamin
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: A variety of descent and major-index statistics have been defined for symmetric groups, hyperoctahedral groups, and their generalizations. Typically associated to pairs of such statistics is an Euler--Mahonian distribution, a bivariate generating function identity encoding these statistics. We use techniques from polyhedral geometry to establish new multivariate generalizations for many of the known Euler--Mahonian distributions. The original bivariate distributions are then straightforward specializations of these multivariate identities. A consequence of these new techniques are bijective proofs of the equivalence of the bivariate distributions for various pairs of statistics.
description: version 3 contains a corrected version of one of the type B theorems and omits a type D result
Correlation potentials for molecular bond dissociation within the self-consistent random phase approximation
Creators: name: Hellgren, M.
name: Rohr, D. R.
name: Gross, E. K. U.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Self-consistent correlation potentials for H$_2$ and LiH for various inter-atomic separations are obtained within the random phase approximation (RPA) of density functional theory. The RPA correlation potential shows a peak at the bond midpoint, which is an exact feature of the true correlation potential, but lacks another exact feature: the step important to preserve integer charge on the atomic fragments in the dissociation limit. An analysis of the RPA energy functional in terms of fractional charge is given which confirms these observations. We find that the RPA misses the derivative discontinuity at odd integer particle numbers but explicitly eliminates the fractional spin error in the exact-exchange functional. The latter finding explains the accurate total energy in the dissociation limit.
description: 9 pages, 10 figures
Knowledge and attitudes towards shaken baby syndrome among parents in Al-Aasa region, Saudi Arabia
Creators: name: Al Noaim, Khalid
Publisher: name: Zenodo
Year: 2025

description: This questionnaire includes several questions to measure knowledge about shaken baby syndrome and attitudes toward it.

The questionnaire covered parents' knowledge and awareness about shaken baby syndrome with one or more correct answers per question. The study questionnaire's validity and reliability were assessed via a pilot study of 20 participants. The tool reliability was 0.73 based on α-Cronbach's.
Understanding need of "Uncertainty Analysis" in the system Design process
Creators: name: Vasantrao, Kardile Vilas
Publisher: name: arXiv
Year: 2011
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Software project development process is requiring accurate software cost and schedule estimation for achieve goal or success. A lot it referred to as the "Intricate brainteaser" because of its conscience attribute which is impact by complexity and uncertainty, Generally estimation is not as difficult or puzzling as people think. In fact, generating accurate estimates is straightforward-once you understand the intensity of uncertainty and module which contribute itself process. In our everyday life, we enhance our estimation based on past experience in which problem solve by which method and in which condition and which opportune provide that method to produce better result . So, Instead of unexplained treatises and inflexible modeling techniques, this will guide highlights a proven set of procedures, understandable formulas, and heuristics that individuals and complete team can apply to their projects to help achieve estimation ability with choose appropriate development approaches In the early stage of software life cycle project manager are inefficient to estimate the effort, schedule, cost estimation and its development approach .This in turn, confuses the manager to bid effectively on software project and choose incorrect development approach. That will directly effect on productivity cycle and increase level of uncertainty. This becomes a strong cause of project failure. So to avoid such problem if we know level and sources of uncertainty in model design, It will directive the developer to design accurate software cost and schedule estimation. which are require l for software project success. This paper demonstrates need of uncertainty analysis module at the modeling process for assist to recognize modular uncertainty system development process and the role of uncertainty at different stages in the modeling
description: 11 pages, 2 figures,1 tables
‘I loved exploring a new dimension of reality’ – a case study of middle-school girls encountering Einsteinian physics in the classroom
Creators: name: Kersting, Magdalena
name: Schrocker, Gretchen
name: Papantoniou, Sandra
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: In recent years, the science education research community has become increasingly interested in the learning domain of Einsteinian physics (EP). While the literature has provided accounts of how EP education can impact secondary and undergraduate students’ attitudes and engagement with physics, we still lack such research with younger students. This exploratory case study addresses this need and adds to our knowledge of how middle-school girls’ experience EP in the classroom. We report on an EP programme run with 39 girls (14–15 years) in an independent day and boarding school in Australia. Based on a phenomenographic analysis of focus group interviews and open-ended questionnaires, we document the range of students’ experiences of EP. The analysis revealed three categories of description that correspond to a personal, scientific, and holistic way of experiencing EP. These experiences influence the girls’ perception of and orientation to physics by increasing interest in physics, challenging traditional stereotypes, and showing future possibilities such as career paths in science. Our findings inform a discussion about improving instructional practices in science classrooms to realise the full potential of EP education. Furthermore, our study adds to a growing body of research that aims to foster middle-school girls’ interest in physics.
Per uno studio sulla procedura delle concordanze
Creators: name: Di Martino, Luca Andrea
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Concordanze, esemplificazione, struttura, filologia, linguistica

description: La procedura delle concordanze individua una tecnica interpretativa che solo in apparenza ritrova la propria ragione nello strutturalismo più sorvegliato: prima ancora di essere un metodo di studio, è di fatto una possibilità del testo, dal punto di vista del lettore, del critico e dell’autore. Qui si guarda alle concordanze anzitutto attraverso l’esperienza di tre filologi del secolo scorso (Barbi, Contini e Avalle), per proporne infine un esame per dir così tecnico, richiamando una categoria in particolare riproposta da Franco Brioschi (l’esemplificazione).
description: ENTHYMEMA, No 7 (2012)
A systematic analysis of the role of the cytoskeleton in Drosophila melanogaster muscle maintenance
Creators: name: Perkins, Alexander David
Publisher: name: University of British Columbia
Year: 2013

description: Animal muscles must maintain their function while bearing substantial mechanical loads and undergoing numerous contraction/extension cycles. How muscles withstand persistent mechanical strain is presently not well understood. The basic unit of muscle is the sarcomere, which is primarily composed of cytoskeletal proteins. I hypothesized that cytoskeletal proteins undergo renewal via protein turnover and that this is required to maintain muscle function. Using the adult flight muscles of the fruit fly, Drosophila melanogaster, I confirmed that the sarcomeric cytoskeleton undergoes turnover throughout the life of the organism. To uncover which cytoskeletal components are specifically required to maintain adult muscle function I performed an RNAi-meditated knockdown screen in adult D. melanogaster targeting the entire fly “cytoskeletome”, the set of known cytoskeletal and cytoskeletal-associated proteins. Systematic gene knockdown was restricted to adult flies and muscle function was analyzed with behavioural assays. This approach identified 47 genes required for maintaining muscle function, 40 of which had no previously known role in this process. Detailed analysis of the role of candidate genes in adult muscles using confocal and electron microscopy showed that while muscle architecture was largely maintained after gene knockdown, maintenance of sarcomere length was disrupted. Specifically, I found that the ongoing synthesis and turnover of the key structural sarcomere component Projectin (bent) was required to maintain M-line integrity. Together, these results provide direct in vivo evidence of muscle protein turnover and identify possible roles for this process by uncovering specific functional defects associated with reduced expression of a subset of cytoskeletal proteins in the adult animal.
Neutrinos with Lorentz-violating operators of arbitrary dimension
Creators: name: Kostelecky, Alan
name: Mewes, Matthew
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The behavior of fermions in the presence of Lorentz and CPT violation is studied. Allowing for operators of any mass dimension, we classify all Lorentz-violating terms in the quadratic Lagrange density for free fermions. The result is adapted to obtain the effective hamiltonian describing the propagation and mixing of three flavors of left-handed neutrinos in the presence of Lorentz violation involving operators of arbitrary mass dimension. A characterization of the neutrino coefficients for Lorentz violation is provided via a decomposition using spin-weighted spherical harmonics. The restriction of the general theory to various special cases is discussed, including among others the renormalizable limit, the massless scenario, flavor-blind and oscillation-free models, the diagonalizable case, and several isotropic limits. The formalism is combined with existing data on neutrino oscillations and kinematics to extract a variety of measures of coefficients for Lorentz and CPT violation. For oscillations, we use results from the short-baseline experiments LSND and MiniBooNE to obtain explicit sensitivities to effects from flavor-mixing Lorentz-violating operators up to mass dimension 10, and we present methods to analyze data from long-baseline experiments. For propagation, we use time-of-flight measurements from the supernova SN1987A and from a variety of experiments including MINOS and OPERA to constrain oscillation-free Lorentz-violating operators up to mass dimension 10, and we discuss constraints from threshold effects in meson decays and Cherenkov emission.
description: 35 pages two-column REVTeX
Breve fenomenologia del lettore ai confini del nonsense (o Il lettore provocato)
Creators: name: Rossi, Laura Lucia
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Nonsense, teoria della risposta estetica, interpretazio-ne, lettore implicito, genere letterario.

description: In questo articolo esaminiamo alcuni generi letterari che sono stati spesso accostati al nonsense letterario. In particolare prendiamo in considerazione il ruolo del lettore all’interno di questi testi e ne proponiamo una sorta di fenomenologia. Invitiamo, infine, a riflettere su come considerare la dimensione del lettore all’interno di un genere letterario possa condurre a risultati rilevanti circa la definizione del genere stesso.
description: ENTHYMEMA, No 7 (2012)
Role of Bose Statistics in Crystallization and Quantum Jamming
Creators: name: Boninsegni, M.
name: Pollet, L.
name: Prokof'ev, N.
name: Svistunov, B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Indistinguishability of particles is a major factor destabilizing crystalline order in Bose systems. We describe this effect in terms of damped quasi-particle modes and in the dual language of Feynman paths, and illustrate it by first-principle simulations of dipolar bosons and bulk condensed helium-four. The first major implication is that, contrary to conventional wisdom, zero-point motion alone cannot prevent helium-four crystallization at low temperature, at saturated vapour pressure. Secondly, Bose statistics leads to quantum jamming at finite temperature, dramatically enhancing the metastability of superfluid glasses. Only studies of indistinguishable particles can reliably address these issues.
Il sapere inquietante di Elvio Fachinelli: una psicoanalisi ‘anni Settanta’
Creators: name: Diazzi, Alessandra
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Fachinelli, psicoanalisi italiana, anni Settanta

description: L’articolo “Il sapere inquietante di Elvio Fachinelli: una psicoanalisi ‘anni Settanta’” propone una riflessione sull’avvento, lo sviluppo e la ricezione della psicoanalisi in Italia durante gli anni Settanta. L’analisi della figura dello psicoanalista italiano Elvio Fachinelli e della sua peculiare pratica psicoanalitica è finalizzata ad una più ampia comprensione del clima politico, sociale e culturale del decennio caldo italiano, a partire dal Sessantotto in poi. In questo periodo, infatti, la psicoanalisi di Elvio Fachinelli non rimane affatto una questione clinica avulsa dal contesto sociale, al contrario legandosi strettamente ad alcune delle questioni più peculiari e rappresentative dell’epoca considerata. Un’analisi delle posizioni di Fachinelli, dunque, oltre a mettere in luce svariati e significativi aspetti dei rapporti della psicoanalisi con il contesto socio-culturale degli anni Settanta, illuminerà quest’ultimo tramite una rilettura dal punto di vista di quel «sapere inquietante» –così Fachinelli definì la psicoanalisi- capace di restituire un’innovativa mappa del momento storico, del background culturale e dei suoi rapporti con il presente.
description: ENTHYMEMA, No 7 (2012)
Lampi di possibili tempeste. Arte e letteratura nel Foucault degli anni Settanta.
Creators: name: Melegari, Diego
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Michel Foucault, scrittura, sapere pittorico, esperien-za, evento

description: Dopo avere rivestito un ruolo fondamentale negli scritti archeologici degli anni Sessanta, i riferimenti a pittura e letteratura sembrano scomparire dalla riflessione foucaultiana. Si tratta, in realtà, di uno slittamento dalle opere maggiori a brevi interventi in cui ad emergere è soprattutto il coinvolgimento soggettivo di Foucault. Questo passaggio, però, non è che un aspetto di una radicale riformulazione della funzione storico-ontologica precedentemente attribuita a letteratura e arte in favore di forme di esperienza non-strategica, dunque irriducibile al nesso potere-resistenza, e allo stesso tempo riattivabile come critica, anche politica, nel rapporto tra tempo storico e trasformazione della soggettività.
description: ENTHYMEMA, No 7 (2012)
«A/traverso» la transizione. Le pratiche culturali del movimento del ’77 e il paradigma artistico
Creators: name: Mariscalco, Danilo
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Autonomia, maodadaismo, superamento dell‟arte, general intellect

description: Il cosiddetto movimento del ’77, già negli anni della sua emersione ricondotto alle esperienze delle avanguardie artistiche del primo Novecento, riconfigurò i dispositivi di produzione-fruizione della cultura producendo un capovolgimento – orientato verso l’autorappresentazione politica dell’emergente proletariato giovanile – delle tradizionali categorie e mediazioni sociali ancora agenti nella società fordista.
description: ENTHYMEMA, No 7 (2012)
«Faccio delle cose coi libri» Calvino vs anni Settanta
Creators: name: Giovannetti, Paolo
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Italo Calvino, Se una notte d’inverno un viaggiatore, lettera-tura e politica, you-narrative, metafiction

description: Se una notte d’inverno un viaggiatore di Italo Calvino giudica in modo severo gli anni Settanta soprattutto italiani, di cui denuncia gli eccessi politici e ideologici. Il fatto ha un interessante risvolto tecnico, poiché il racconto in seconda persona realizzato nel romanzo ha la funzione sia di manipolare un intero mondo (quello degli anni Settanta, appunto) fino a cancellarlo, sia di difendere la funzione dell’autore, la sua capacità di subordinare a sé l’atto di lettura.
description: ENTHYMEMA, No 7 (2012)
Assessment of tissue heterogeneity in bicuspid ascending aortic aneurysm: mechanics, microstructure, and in vivo biomarkers
Creators: name: Neave, Louise M
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: bicuspid aortic valve
subject: aortic aneurysm
subject: multiphoton microscopy
subject: biomechanics
subject: mechanical testing
subject: soft tissue mechanics
subject: aortic biomechanics
subject: in vivo imaging
subject: gene expression
subject: aortic disease
subject: tissue microstructure
subject: strain
subject: wall shear stress
subject: Engineering--Biomedical
subject: Health Sciences--Medicine and Surgery

description: Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, and often precedes the development of ascending aortic aneurysm (AsAA). The complications associated with AsAA can be fatal, however, reliable and accurate risk assessment metrics have not been established. The aim of this thesis is to present an integrated analyses of the mechanical and microstructural characteristics of BAV AsAA and identify non-invasive, patient-specific biomarkers for advanced risk stratification.Whole aneurysms were removed from BAV patients undergoing elective surgery, and a combination of ex vivo biomechanical testing, microscopy, and quantitative real-time PCR analysis was used to evaluate the variation of AsAA tissue properties by specimen location and layer. Following, location-specific analysis of in vivo strain and wall shear stress was completed and relationships between the in vivo and ex vivo properties were assessed.Results show that mechanical properties and remodeling processes seem to vary between the aortic wall layers, which may help explain the susceptibility of the tissue to different modes of mechanical failure, such as dissection or rupture. Investigation of microstructural and genetic factors in the tissue reveals a potential role of inflammation in the progression of BAV AsAA.The observed heterogeneity of tissue properties at the micro- and macro- scale emphasizes the importance of patient-specific assessment and treatment. Relationships between tissue properties and patient-specific biomarkers are assessed, and wall shear stress, in vivo strain, and patient age are identified as non-invasive measures that relate directly to the tissue biomechanics.We conclude that the heterogeneity of aortic wall layers and their unique remodeling response may be significant in AsAA progression, and computational models may be improved by consideration of the composite nature of the aortic wall. Additionally, the proposed patient-specific biomarkers may offer an improved means of evaluating risk of complications for clinical management of BAV patients in the future.
On the validity of the adiabatic approximation in compact binary inspirals
Creators: name: Maselli, A.
name: Gualtieri, L.
name: Pannarale, F.
name: Ferrari, V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Using a semi-analytical approach recently developed to model the tidal deformations of neutron stars in inspiralling compact binaries, we study the dynamical evolution of the tidal tensor, which we explicitly derive at second post-Newtonian order, and of the quadrupole tensor. Since we do not assume a priori that the quadrupole tensor is proportional to the tidal tensor, i.e. the so called "adiabatic approximation", our approach enables us to establish to which extent such approximation is reliable. We find that the ratio between the quadrupole and tidal tensors (i.e., the Love number) increases as the inspiral progresses, but this phenomenon only marginally affects the emitted gravitational waveform. We estimate the frequency range in which the tidal component of the gravitational signal is well described using the stationary phase approximation at next-to-leading post-Newtonian order, comparing different contributions to the tidal phase. We also derive a semi-analytical expression for the Love number, which reproduces within a few percentage points the results obtained so far by numerical integrations of the relativistic equations of stellar perturbations.
description: 13 pages, 1 table, 2 figures. Minor changes to match the version appearing on Phys. Rev. D
Use of measurement while drilling techniques for improved rock mass characterization in open-pit mines
Creators: name: Babaei Khorzoughi, Mohammad
Publisher: name: University of British Columbia
Year: 2014

description: Rock mass properties for a mining area are generally determined based on information obtained from the ore - body model (based on exploration data), visual observations in combination with other indices obtained from physical sample testing or geophysical logging. One of these indices is the blastability index. Blastability is generally dependent upon the geological and geomechanical properties of a rock mass in terms of such factors as intact strength as well as the degree and extent of fractures. Accurate determination of the blastability is a critical element that can be used for mine planning towards achieving higher loading and hauling efficiency through more optimal fragmentation. Based on previous works, a reasonable estimate of the rock mass blastability has been shown to be derived from the performance monitoring of blasthole drills using tricone bits. The current work aims to build upon the previous efforts through the creation of a comprehensive model and approach that can predict a range of blastability results for a broad array of variables such as: operating conditions, structural features, etc. More specifically, the research will evaluate and enhance an Alpha Blastability. Index Algorithm (Compensated Blastability Index) originally defined by a mining technology company (Peck Tech Consulting Ltd.) in 2008. This Alpha CBI algorithm was never fully tested, validated nor verified in terms of its ability to consistently and repeatedly generate accurate blastability data. The Alpha CBI algorithm was based on Measurement While Drilling (MWD) data and an associated suite of geophysical logs for the same blastholes during comprehensive field studies in an open-pit copper operation in British Columbia, Canada. The improved Alpha CBI algorithm that results from the current research has been designed to use drill monitored data to generate improved blastability indices that provide more detailed information on in-situ rock mass properties than the previous approach. It accomplishes this by an enhanced ability to identify zones of fractured rock and subsequently compensating for their presence. The resulting blastability indices thus derived through this new method have been shown to more closely reflect the true in-situ rock mass conditions as validated when correlated to the geophysical logs.
Stochastic target games with controlled loss
Creators: name: Bouchard, Bruno
name: Moreau, Ludovic
name: Nutz, Marcel
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optimization and Control (math.OC)
subject: Probability (math.PR)
subject: Pricing of Securities (q-fin.PR)
subject: FOS: Mathematics
subject: FOS: Economics and business

description: We study a stochastic game where one player tries to find a strategy such that the state process reaches a target of controlled-loss-type, no matter which action is chosen by the other player. We provide, in a general setup, a relaxed geometric dynamic programming principle for this problem and derive, for the case of a controlled SDE, the corresponding dynamic programming equation in the sense of viscosity solutions. As an example, we consider a problem of partial hedging under Knightian uncertainty.
description: Published in at http://dx.doi.org/10.1214/13-AAP938 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)