cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: of Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L.
Creators: name: Tian, Maozhu
name: Nie, Qiong
name: Li, Zhenhua
name: Zhang, Jie
name: Liu, Yiling
name: Long, Yao
name: Wang, Zhiwei
name: Wang, Guoqing
name: Liu, Renxiang
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology
subject: Virology

description: Table S1. The primer sequences of the randomly selected genes used for RT-PCR validation. (DOCX 16Â kb)
Leaflet: attributional LCA for legumes and legume-based products
Creators: name: Styles, David
name: Costa, Marcela Porto
name: Williams, Michael
name: Saget, Sophie
name: Zimmermann, Beate
name: Barilli, Eleonora
name: Black, Kirsty
name: Lehrack, Uwe
name: Löhrich, Nora
name: Bienkowski, Damian
name: Iannetta, Pietro
Publisher: name: Zenodo
Year: 2020
Subjects: legumes
environmental footprints
crop rotations
protein
alcohol

description: The leaflet described in this project Deliverable highlights key methodology and footprint results for legume food and feed products. It summarises some key findings on legume environmental footprints from an attributional Life Cycle Assessment (LCA) undertaken in WP5. Carbon footprint results are presented for beans, chickpeas, soybean, lupins and peas across the three European biogeographical regions – Atlantic/Boreal, Continental and Mediterranean. Key results for pea-gin, pea protein balls and chickpea pasta are also highlighted as example case studies.
The effect of fetal valproate exposure on memory function and hippocampal structure in school-aged children
Creators: name: Barton, Sarah May
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Women with epilepsy are usually advised to continue taking anti-epileptic drugs (AEDs) throughout pregnancy due to the dangers that uncontrolled seizures can pose for both mother and fetus. Compared to other AEDs, sodium valproate (VPA) has been associated with greater risk of birth defects and cognitive impairment. Previous research suggests that VPA impacts on the development of intellectual abilities, however the long-term effect of fetal VPA exposure on other cognitive skills has been poorly characterised. Further, it is unknown whether abnormalities in brain structure underlie these cognitive deficits. This research aimed to investigate memory functioning and hippocampal structure in school-aged children who were exposed to VPA in the intrauterine environment. One hundred and five prospectively recruited school-aged children (aged six to eight years) exposed to AEDs in utero participated in the study. The sample included 26 children exposed to VPA monotherapy and 15 exposed to VPA polytherapy. All children underwent a neuropsychological assessment that included measures of memory. MRI scans were also collected from 14 children exposed to VPA monotherapy. Results from neuropsychological measures showed that verbal memory skills were negatively affected by exposure to VPA, in a dose-dependent manner. Conversely, non-verbal memory abilities were developmentally appropriate. Language impairment appeared to underlie the reduced performance on some verbal memory measures, except for on a measure of retroactive interference. Analyses of the imaging data did not reveal differences between left and right hippocampal volumes (after controlling for head size) in children exposed to VPA monotherapy. VPA dose was not correlated with hippocampal volume; however there was a significant relationship between hippocampal volume and associative learning ability. These data provide evidence of memory impairment in school-age children exposed to VPA, adding additional weight to the argument that VPA places children at risk of poorer developmental outcomes. The results suggest that these deficits in memory functioning may be partly mediated by abnormal hippocampal development; however studies with larger sample sizes and the inclusion of controls are warranted. The findings suggest that the prescription of VPA to women of childbearing age should be carefully considered in terms of risks and benefits. Women taking VPA should be supported throughout pregnancy and their children monitored from an early age. Future research is required to improve detection of children at risk and develop effective intervention strategies.
Additional file 3: of Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L.
Creators: name: Tian, Maozhu
name: Nie, Qiong
name: Li, Zhenhua
name: Zhang, Jie
name: Liu, Yiling
name: Long, Yao
name: Wang, Zhiwei
name: Wang, Guoqing
name: Liu, Renxiang
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Table S3. Number of genes with different expression levels. (DOCX 13Â kb)
Additional file 4: of Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L.
Creators: name: Tian, Maozhu
name: Nie, Qiong
name: Li, Zhenhua
name: Zhang, Jie
name: Liu, Yiling
name: Long, Yao
name: Wang, Zhiwei
name: Wang, Guoqing
name: Liu, Renxiang
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Figure S1. Volcano plots of significant DEGs in hybrid F1 and its parents in Nicotiana tabacum L. The X-axis represents the average value and the Y-axis represents the log2 fold-change. Up- or downregulated genes are shown in red (PÂ <â 0.05) and the others are shown in black (Figure S1A, F1 vs. VA116; Figure S1B, F1 vs. Basma; Figure S1C, VA116 vs. Basma).
Green chemical solutions for the separation of recombinant proteins, including biopharmaceuticals
Creators: name: Coghlan, Campbell James
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The purification of recombinant proteins is a rapidly expanding industry which currently relies on multistep purification and multiple techniques to purify a small amount of protein. One of the techniques to purify these recombinant proteins on a laboratory scale is Immobilised Metal Affinity Chromatography (IMAC). However, the technique is not commonly used on an industrial scale. The advantages of IMAC are its low cost, relatively high protein loading, simplicity of regeneration of the matrix and that it only requires mild elution conditions. To be used on an industrial scale the system is required to have limited or no metal leakage, be highly specific to the protein of interest and be able to be reused multiple times; in essence lowering cost. The focus of this thesis is on the synthesis of existing and novel bis(tacn) ligands and sustainable methods for producing these ligands based on the 12 principles of Green Chemistry. It was found that the existing methods could be made approximately four times more efficient by moving away from the traditional route for the synthesis of tacn. These ligands were characterised by many methods. The metal complexes of the ligands were characterised by X-ray crystallography which gave insight into how the metal ions may bind to the tagged protein. The ligands were immobilised onto Sepharose FF and bound to copper(II), nickel(II) and zinc(II). These adsorbents were then tested using high throughput screening, on a Tecan Evo 200 robotic platform, to test for binding using green fluorescent protein (GFP) as the model protein. The ability to test immobilised ligands using the robot allowed for high accuracy of results and minimal waste, along with being able to screen a library of ligands with different metals. The results obtained show an increase in capacity against commercially available ligands and stronger binding of the tagged protein. The adsorbents showed no metal leakage once bound, and could be reused multiple times (> 10) without the need to reload the metal and minimal loss of efficiency. The immobilised ligand metal complexes also showed a high selectivity for the tagged protein. The results shown in this thesis describe more sustainable methods for both synthesising the ligands and purifying proteins, with the purification process being easily scalable.
The Art of MR. Staging the Connectome.
Creators: name: Heuer, Katja
name: Böttger, Joachim
name: Schurade, Ralph
Publisher: name: Zenodo
Year: 2016
Subjects: interactive installation
neuroanatomy
neuroimaging
fiber tracts
diffusion weighted imaging
data visualization
brain
art
sci-art

description: An interactive visualization of brain data. This interactive installation uses high resolution state-of-the-art data derived from the Leipzig Max Planck Institute’s magnetic resonance imaging systems. In addition to the cortical anatomy, we visualise the shape of anatomical connections between functional areas. According to their direction, these fibres are presented in different colours: fibres running from front to back are shown in green; fibres from top to bottom are blue and fibres which interconnect the two hemispheres are red. “Staging the Connectome.” allows viewers to explore the brain and its connections while navigating the data with their own movement. An Xbox Kinect tracks the position of the users’ heads inside the room. For one viewer, one or multiple perpendicular slices are projected with a very direct coupling of user movement and slice transition—it feels like walking through your own brain. For two viewers, two so-called regions of interest are coupled with the viewers’ head positions, and the fibre connections between these two are displayed. In this visualisation format you can explore neuroscientific data in a beautiful and intuitive way—the proportions of the brain are respected and directly translate into the virtual brain space of approximately 3.5 by 2.5 by 2.5 meters.

 You can watch a video of the interactive installation here (4 min with short explanations): https://www.youtube.com/watch?v=LtsBZlw5nQI or here (3 min "best of" without explanations): https://www.youtube.com/watch?v=6hMNZHsrNHw Details about the first implementation of the interactive installation can be found on https://zenodo.org/record/3596593 For more information please see the `_details.pdf` file.
Water and Related Land Resource, Big Sioux River Basin and Related Areas, South Dakota, Minnesota, Iowa
Creators: name: Soil Conservation Service
name: Service, Forest
name: Economic Research Service
name: Soil Conservation Service
name: Service, Forest
name: Economic Research Service
Publisher: name: Unknown
Year: 1973
Subjects: Agricultural and Food Policy
Community/Rural/Urban Development
Crop Production/Industries
Environmental Economics and Policy
Labor and Human Capital
Land Economics/Use
Livestock Production/Industries
Resource /Energy Economics and Policy

description: Excerpts from the report: The Big Sioux Study Area is located in eastern South Dakota, southwest Minnesota, and northwest Iowa. It contains 7,582,080 acres, or 11,847 square miles and includes the 9,371 square miles of drainage of the Big Sioux River and an additional 2,476 square miles within the boundary of the East Dakota Conservancy Sub-District of South Dakota. About 76 percent of the Study Area is in South Dakota 12 percent in Minnesota, and 12 percent in Iowa. This cooperative Type IV Study was prepared by the U. S. Department of Agriculture at the request of responsible state agencies in Iowa, Minnesota, and South Dakota for the purpose of providing land, water, and related resource information to facilitate the planning and orderly conservation, development, utilization, and management of these resources in the Study Area. The study included the following principal objectives: 1. Appraisal of the agricultural and nonagricultural damages caused by floodwater, water erosion, sediment, impaired drainage, and wind erosion. 2. Appraisal of land use and land treatment practices as they relate to soils, erosion, and the use of land within its capabilities. 3. Determination of an efficient system of land treatment and structural measures which would alleviate the problems relating to watershed protection, flood prevention, drainage, water supply management, pollution, fish and wildlife, water quality control, and recreation. 4. Identification of opportunities and solutions that can be carried out by the U.S. Department of Agriculture and other federal, state, and local agencies under existing authorities, and those activities that should be developed under amended or new authorities. 5. Evaluation of the impact of the proposed programs on the physical, economic, social, and environmental factors. 6. Preparation of a report describing present and future problems and needs pointing out the potential solution opportunities.
description: In Cooperation With: South Dakota Water Resources Commission, South Dakota Conservation Commission, East Dakota Conservancy Sub-District, Minnesota Department of Natural Resources, Iowa Soil Conservation Commission
Business & human rights: the future of corporate accountability for human rights violations in the extractive sector
Creators: name: Kapesa, Melba Ethel
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The accountability for human rights violations by multinational corporations (“MNCs”) has been one of the most debated human rights issues of the last decade. Nongovernmental organisations, industry groups, governments and even businesses themselves have generated a plethora of recommendations on how best to respond to the negative human rights impacts created by MNCs that operate in States that are unable or unwilling to protect their citizens’ human rights. While there is broad agreement among these different stakeholders about the need for an effective regulatory regime, there is less agreement about the form that this should take. The landmark ‘Protect, Respect and Remedy’ framework proposed in 2008 by John Ruggie, the former Special Representative of the United Nations (“UN”) Secretary-General on the issue of business and human rights, followed in 2011 by its ‘Guiding Principles on Business and Human Rights’ (together, the “UN Framework”), has been hailed as the most significant and progressive instrument to date in the business and human rights domain. But, can the UN Framework be considered a game-changer in that it guarantees that victims of MNC human rights abuses are able to obtain effective remedy? This thesis will explore the causes, challenges and possible future remedies of MNC human rights accountability in three distinct ways. First, it will canvass the possible ways in which businesses affect the human rights of individuals and posit a theory of corporate accountability embedded in the fundamental value of human dignity. Secondly, it will evaluate major policy frameworks that purport to regulate MNC human rights responsibilities, including the newly launched UN Framework, with a view to exposing their (in)adequacy in addressing MNC human rights violations. Finally, it will suggest necessary reforms or alternative enforcement mechanisms, which could be used to enhance MNCs human rights accountability at the international realm with both voluntary and legal dimensions.
Additional file 1 of Analysis of barriers associated with emergency medical service activation in patients with acute stroke and acute myocardial infarction from Zhongjiang County of Sichuan Province in China
Creators: name: He, Chengcheng
name: Zhang, Yingchun
name: Tang, Meimei
name: Ai, Xiaohua
name: Tang, Mingxiang
name: Tang, Cheng
name: Li, Li
name: Huang, Wenjin
name: You, Xin
name: Zhou, Dewen
name: Zhou, Jiming
name: Shi, Yan
name: Luo, Min
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 1
The United Nations convention on the rights of persons with disabilities and mental health in Australia
Creators: name: Kämpf, Annegret
Publisher: name: Monash University
Year: 2019
Subjects: Uncategorized

description: This thesis examines whether or not current Australian mental health legislation complies with the Convention on the Rights of Persons with Disabilities (the CRPD) which Australia ratified on 17 July 2008. It analyses the meaning of specific provisions of the CRPD that are most relevant to persons with psychosocial disabilities. It assesses whether mental health legislation should be abolished or reformed. It argues that Australian mental health acts conflict with the CRPD and should be abolished. Given Australia's interpretative declaration on ratifying the CRPD that the CRPD allows for the involuntary detention and treatment of persons with mental disabilities, it is unlikely that mental health legislation will be abolished in Australian jurisdictions. However, this thesis argues that the CRPD provides a new and tangible normative framework for the reform of mental health laws and this thesis sets out the steps that need to be taken to ensure that persons with psychosocial disabilities have equal standing in society and are protected from being subject to differential treatment in law and practice. The legislation in this thesis is as at 1 July 2011.
Additional file 1: of Qcorp: an annotated classification corpus of Chinese health questions
Creators: name: Guo, Haihong
name: Na, Xu
name: Li, Jiao
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: A brief introduction of the data source websites. This additional file is in PDF format. It contains a table that gives a brief introduction of the data source websites, including their abbreviation, Chinese name, English names, and description. (PDF 58 kb)
Investigation of the interactions between collagen-binding integrins and collagen : binding and structural studies of a 1l domain and collagen mimetic peptides
Creators: name: Chin, Yanni Ka-Yan
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Integrins comprise of a large family of heterodimeric cell adhesion receptors consisting of an α- and a β- subunit. They are responsible for mediating cell-cell and cell-extracellular matrix (ECM) interactions. In addition, they transmit bi-directional (outside-in and inside- out) signals across the plasma membrane, regulating numerous important cellular behaviours including cell adhesion, cell migration and cell communication. Collagen-binding integrins represent one of the five integrin subfamilies and are characterized by their ligand specificity for different collagens. Each α subunit in the collagen-binding subfamily contains an inserted domain, the αI domain, which is responsible for collagen binding. The interactions between two of the most studied collagen-binding integrins, α1β1 and α2β1, and their respective collagen substrates have been implicated in several disease processes, making these receptors attractive therapeutic targets. The initial aim of this project was to identify small molecule scaffolds that are suitable starting points for designing inhibitors of the α1β1-collagen interaction. The approach adopted was fragment-based drug discovery. The lack of structural information on the collagen-bound state of α1I domain, however, made the process very challenging. Therefore, it was decided that the structure of the α1I domain-collagen complex should be characterised to support any subsequent program of rational drug design from the fragment-based approach. A variety of techniques were employed to characterise the interactions between α1I domain and synthetic collagen peptides. These included surface plasmon resonance spectroscopy (SPR) which provided details of the affinity and kinetics of binding, size exclusion chromatography and small angle X-ray scattering that revealed an unexpected stoichiometry of binding, NMR experiments that enabled the structure of α1I domain to be determined in the presence of a collagen peptide and computer docking using the data-driven docking program, HADDOCK, to generate a model of the entire α1I domain-collagen peptide complex. Combining the information generated from all these techniques in conjunction with previously reported structural and mutagenesis studies, a detailed insight into the interaction was provided. Not only do these results provide a structural rationale to design inhibitors of collagen binding to α1I domain, they are also valuable for understanding the biological roles and the regulation of this receptor.
Re-presenting the language of painting through the gift an insight into give and take in contemporary art
Creators: name: Hodgeman, Glenys
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: My art practice has unfolded directly from my previous experience as an organ transplant coordinator. During my dealings within organ donation – often denoted as the ‘gift of life’ – I became interested in the broader notion of gift-giving in social practice, especially the relationships created and the meanings associated within the act of giving and receiving gifts. My work revealed that a gift is not as commonly thought, a gratuitous legacy, but instead, a very complex system of shared obligations and an essential element of social bonding. Initially, due to my health background, my art practice addressed ‘gifts’ given upon death (organs and tissues) from one individual to another by means of medical technology. It then focused on gifts as personal possessions given to family members or bequeathed to the state. Just prior to the commencement of my doctorate studies, I had commenced some research and studio practice within areas such as social connection/exchange, motivation and attachment. Through the research, I have become increasingly interested in how an artist (who also gives and hopes to be given) works within the ‘world of the gift’, what motivates the artist or any innovator to produce work, to research and bequeath objects that ultimately aim to enrich lives and social connections. This PhD commenced by centring on the theme of the gift and aims to use the social and cultural significance of the gift as a guiding thread for the reflection on contemporary art practices. I began this study with a particular interest in investigating the relational status of the work of art by focussing on the complexity of the gestures of giving and receiving, of inviting and hosting. I started with the feeling that the idea of the gift could free the current forms of interpersonal interaction and communication that had tended to become uniform, explicit and repetitive within contemporary artistic practices. My studio practice changed dramatically from sculpture to painting as I discovered the airbrush. The airbrush allowed me to scan over the history of painting, picking styles and reworking them. The airbrush showed me new ways to try and attempt to establish new forms of relationships between my work, the viewer and me. The airbrush allowed me to read with more depth, through reference to the notion of the gift: new bonds, new forms of generosity and seduction, new snares. In the context in which the gaze tends to become consumption and the image stimulus, the exchange among people in a meaningless, repeatable and predictable transaction, it became ever more attractive to think that painting could be represented via the airbrush and the work of art as ‘gift’.
Thermochromic composite fibres for thermal mapping in the physiological temperature range
Creators: name: Van Der Werff, Louise
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis presents original work towards the successful formation of novel thermochromic composite fibres through melt extrusion processes, and whose major application includes incorporation into wound dressings and garments, for the thermal mapping of chronic wound bed surfaces and skin surfaces, within the physiological temperature range. Specifically, this work focuses on the incorporation of thermochromic liquid crystalline (TLC) mixtures into host materials in fibre form, such that clear and reliable thermochromic behaviour is preserved, and a good colour density is maintained. TLC mixtures containing both sterol based, and non-sterol based compounds were used. The relationship between composition and thermochromic behaviour for binary and ternary TLC mixtures consisting of a selection of cholesterol derivatives is also explored in this work. Crucial to the success of the TLC containing composite fibres was the insertion of a black core material through the centre of the fibres, addressing the inherent need for TLCs to be viewed against a black or dark background for their reflected colours to be visible. Two major methods of incorporation of the TLC into a host fibre were presented using melt extrusion processes. The most successful monofilament composite fibre’s thermochromic behaviour was found to be clear, and comparable to that of unincorporated TLC mixtures. The thermochromic behaviour was found to remain stable after storage in air for at least 17 weeks, provided that the fibres were not also exposed to light. Their behaviour also remained stable upon submersion in water and saline solution, for at least 10 days. The inherent instability of TLCs to light induced degradation was unfortunately found to be preserved in these fibres, where a detrimental shift in the thermochromic behaviour of the fibres occurred with intense or long-term exposure to UV light. Methods of avoiding or slowing light induced degradation are discussed. This thesis focuses on the steps taken towards achieving the final successful fibre design, as well as its characterisation, and discussions in regards to its applicability to medical applications.
Chinese middle school mathematics teachers’ practices and perspectives viewed through a western lens
Creators: name: Jin, Xianyan
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This study was designed to investigate Chinese middle school mathematics teachers’ practices and perspectives on knowing and learning that may underlie their observed practices. In particular, this study addressed the following research questions: (a) What pedagogical activities and strategies can be identified in Chinese middle school mathematics teachers’ practices? (b) What teacher perspectives of mathematics knowing and learning may underlie these teachers’ practices? To address these questions, the researcher, a native Chinese who moved to Australia and became an Australian citizen, used a constructivist (western) conceptual framework as a lens. This framework combined two lines of previous work, Ernest’s (1989b) characterisation of mathematics teaching and Simon and Tzur et al.’s (Heinz et al., 2000b; Simon et al., 2000; Tzur et al., 2001) distinction of perspectives that seem to underlie reform-oriented teaching practices. Eleven year-7 middle school mathematics teachers from two different schools located in a Southeast province in Mainland China volunteered to participate in this study. For each of these 11 teachers, a set of data was collected, consisting of two video recorded classroom observations (consecutive lessons) interspersed with three video recorded interviews with the teacher about those observed lessons (before, between, and after each classroom observations). Transcripts of the interviews and classroom observations were translated into English. Six teachers were then selected as case studies and their practices and perspectives were analysed using the constant comparison method proposed by Glaser and Strauss (1967) as part of the Grounded Theory methodology. Findings of this study indicate that, typically, the participating Chinese teachers used a five-component cyclic teaching practice—Reviewing, Bridging, Variation, Summarising, and Reflection/Planning. The first four components constituted their implemented lesson structure. Data are presented to depict the nature of these first four components along with the participating teachers’ rationale for using each component the way they did. The significance of these findings is discussed in terms of a perspective about knowing and learning that seem to underlie the participating teachers’ five-component practice. This perspective appears to differ from perspectives that were identified previously. Coupled with the four-component lesson structure this perspective is discussed in terms of how it may inform mathematics teachers’ development of effective pedagogical practices, as well as future research and theory development.
Loggia et cour d'une maison du Sultan Qaytbay
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: Maison de Qaytbay (Translittération simplifiée)
Bayt Qāytbāy (Translittération normalisée ISO-Bnf)

description: La photographie représente une vue en grand angle de la loggia (Maq'ad) et la cour de la maison du Sultan Qaytbay, sise Sikkat al-Mardani. Des peintures murales ornent une parois de la loggia. Les murs extérieurs semblent porter un ornement géométrique répétitif, peut-être au moyen de stencils. Au deuxième plan nous voyons les arcades de la loggia et de la cour de la maison du Sultan Qaytbay.
description: n° CCMAA : 228
description: La légende portée à l'encre violette sous la photographie stipule Casa del sultano Kaïd Bey (Cairo). La photographie porte le numéro 1, correspondant à l'ordre de la photo dans l'album. Ce numéro est situé au-dessus de l'épreuve et est écrit à l'encre violette. Cette photo porte aussi le timbre sec de Facchinelli, « B. Facchinelli Caire », sur son coin inférieur gauche. La prise de vue est antérieure à 1887, date d'édition de l'album.
description: Cette photo porte le numéro 554 dans d'autres collections.
description: Source: OMEKA
description: Source: Facchinelli B., Raccolta artistica di fotografie sull’architettura araba, ornati ecc. dal XII° al XIII° secolo. Publié en 1887.
description: Relation: Une vue du même bâtiment a été utilisée dans un mémoire publié par les membres de l'Institut français d'archéologie orientale, tome LXII (ou MIFAO 62), écrit par Edmond Pauty, publié en 1933 et porte le titre : Les palais et les maisons d'époque musulmane. Sur les planches XXVI et XXVII, nous retrouvons deux clichés légendés toutes deux « Maison de Kaïtbâï, à Sikkat el-Mardâni. ». L'attribution de ces clichés à Facchinelli n'est pas avérée. Le temps qui sépare ces photos et celle de l'album est trop important pour que l'on puisse établir sans aucun doute une filiation certaine à Facchinelli. Une vue du même bâtiment a été publié dans l'ouvrage de Franz Pacha, Kairo à la page 121.
description: Relation: Même vue, autres vues de Facchinelli et vues du même bâtiment dans d'autres collections : Un tirage d'une autre vue avec un cadrage plus large a été encollée dans l'album Raccolta artistica di fotografie sull’architettura araba, ornati ecc. dal XII° al XIII° secolo, et porte le numéro 2. Un tirage d'une autre vue, légèrement plus large, se trouve dans le fonds Karkégi de la BnF. Les personnages ne sont plus présents au premier plan. La photo porte le numéro 554. Ce tirage se trouve aussi dans le fonds Ballu, Archives 112, carton 11, dossier 12, pièce 034.
description: Coverage: Date du monument A.D. : 1485
description: Coverage: Date du monument A.H. : 890
description: Coverage: GEOMETRYCOLLECTION(POINT(3479599.9298 3508728.25574))
Additional file 1: of Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls
Creators: name: Tian, Fu-Ying
name: Wang, Xi-Meng
name: Xie, Chuanbo
name: Zhao, Bo
name: Niu, Zhongzheng
name: Fan, Lijun
name: Hivert, Marie-France
name: Chen, Wei-Qing
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology

description: Figure S1. Quality control flowchart. Figure S2. The correlation of DNA methylation across all the valid CpG sites in valid samples. The correlation coefficients with the gray background are not statistically significant (Pâ >â 0.05). Figure S3. The scatter plots of placental surface area versus DNA methylation of CpG sites at FGFR2. The coefficient and P value were given by regression of placental surface area on DNA methylation using multiple linear regression model adjusted for maternal age, education, family monthly income, ETS exposure during pregnancy, gestational age and sex. (DOCX 294Â kb)
Additional file 2: of Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls
Creators: name: Tian, Fu-Ying
name: Wang, Xi-Meng
name: Xie, Chuanbo
name: Zhao, Bo
name: Niu, Zhongzheng
name: Fan, Lijun
name: Hivert, Marie-France
name: Chen, Wei-Qing
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology

description: Includes the supplementary method. (DOCX 25Â kb)
Small molecule inhibitors of PDE4
Creators: name: Nankervis, Jacob Leonard
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The phosphodiesterase 4 (PDE4) family of enzymes is a promising drug target for a variety of conditions, including inflammatory conditions such as asthma and chronic obstructive pulmonary disorder (COPD), and neurological conditions such as depression. PDE4 inhibitors include rolipram, which was trialled for the treatment of depression, and roflumilast, which has recently completed clinical trials for the treatment of COPD. Unfortunately, PDE4 inhibitors generally exhibit side effects – mainly, nausea and emesis. The mechanisms underlying these side effects are not fully understood, though several strategies exist in the literature for avoiding them. These strategies usually encourage finding novel structural classes of inhibitors. Here I present work on two structural classes as PDE4 inhibitors. Chapter one introduces the PDE4 enzyme as a drug target and explains the side effects associated with it, and introduces previously studied inhibitor classes. Chapter two describes the synthesis and evaluation of a class of tetrahydrobenzothiophenes as PDE4 inhibitors, with the most potent analogue exhibiting an IC50 of approximately 20 nM. Although this class was serendipitously discovered by my lab and collaborators, a similar compound was recently reported by Kranz et. al. as a selective PDE4B inhibitor. Interestingly, our compounds bind in the active site of PDE4 in a different orientation, as revealed by X-ray co-crystallography. Chapter three builds on this structural information, using molecular docking to design new analogues. Based on docking simulations, the tetrahydrobenzothiophene scaffold was derivatised with different urea groups, with the most potent exhibiting a PDE4 IC50 of 93.03 nM. Additionally, isomeric analogues of the tetrahydrobenzothiophenes of chapter 2 were investigated, though these performed poorly in assays. Chapter four describes flavonoids as a possible source of PDE4 inhibitors. Flavonoids are a class of naturally occurring polyphenolic compounds that display a range of biological activities. There have been some indications that this class may be a useful source of phosphodiesterase inhibitors. Here I investigated a series of chromone compounds bearing a 2-tetrahydopyranyl group. In PDE4 assays, the most potent compounds exhibited IC50s of approximately 0.4 μM.
ByzRev2020.004: Marcel Frederik Schwarze, Byzanz und das 6. Jahrhundert. Norderstedt 2018
Creators: name: Wahlbring, Jennifer
Publisher: name: The Byzantine Review
Year: 2020

description: Marcel Frederik Schwarze, Byzanz und das 6. Jahrhundert. Alltagskultur, Hinterlassenschaft und Veränderung – Aufbruch und Umbruch im Reich der Römer. Norderstedt: Books on Demand 2018, 168 S. – ISBN: 978-3-7481-3026-0 (29,99€)
description: The Byzantine Review, Bd. 2 (2020)
Affective decision making and psychopathic traits
Creators: name: Hughes, Melissa Ann
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Psychopathy is a complex developmental personality disorder, which is associated with higher risks of offending, recidivism, and poor treatment responsivity. Recent neurocognitive explanations have linked psychopathy to dysfunction in the frontostriatal circuit linking the amygdala and ventromedial prefrontal cortex (vmPFC), which is responsible for the reciprocal modulation of emotion and cognition. Disruptions in this circuit could therefore alter the ability to learn from punishment and reward, impacting on decision making. The overall goal of the studies presented in my thesis was to assess the relationships between decision making and psychopathy. Due to the multidimensional nature of psychopathy, in addition to examining overall psychopathy, we also assessed underlying psychopathy characteristics. We assessed relationships between decision making and psychopathy in a sample of prisoners (n=60) and community members (n=20). Psychopathic traits were characterised using the Psychopathic Personality Inventory – Revised (PPI-R) and the Psychopathic Check List: Screening Version (PCL:SV). Decision making was assessed using the Moral Judgement Task (MJT), The Regret Task, and the Iowa Gambling Task (IGT). Participant’s choices on the IGT were additionally analysed using the Prospect Valence Learning (PVL) model to extract the specific cognitive processes relating to their decisions. We found that higher scores on psychopathy measures were associated with endorsement of more harmful social actions on the MJT, but not with general deficits in experience of regret or deficits in decision making on the IGT. In each decision making task, specific aspects of psychopathy related differentially to performances, suggesting that psychopathic traits could differentially relate to decision making processes. Thus, the key finding of our studies was that there is specificity between psychopathy traits and the various elements and types of decision making we studied. Such relationships were found across three different decision making tasks, supporting the validity of trait-specific and decision task specific relationships. A key outcome of our findings is the need for further development of robust tools that can accurately capture and quantify psychopathy traits in both prison and community samples. Further investigation into the relationship between decision making and psychopathic traits with more robust measures will lead to further uncovering the cognitive underpinnings of this complex disorder. In turn, this information will provide essential evidence for developing treatments that are more specifically targeted at the underlying cognitive and motivational processes at play in psychopathy.
Additional file 1: of The association of mammographic density with risk of contralateral breast cancer and change in density with treatment in the WECARE study
Creators: name: Knight, Julia
name: Blackmore, Kristina
name: Fan, Jing
name: Malone, Kathleen
name: John, Esther
name: Lynch, Charles
name: Vachon, Celine
name: Bernstein, Leslie
name: Brooks, Jennifer
name: Reiner, Anne
name: Liang, Xiaolin
name: Woods, Meghan
name: Bernstein, Jonine
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Table S1. Comparison of odds ratios and 95% confidence intervals for association between %MD and CBC across different time windows. Table S2. Association of %MD categories prior to/at first diagnosis and post-diagnosis with CBC risk by menopausal status. Table S3. Association of chemotherapy regimen and radiation dose with change in %MD. (DOCX 19 kb)
title: 01_0421
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
A high frequency missense SULT1B1 allelic variant (L145V) selectively expressed in African descendants exhibits altered kinetic properties
Creators: name: Tibbs, Zachary E.
name: Guidry, Amber L.
name: Falany, Josie L.
name: Kadlubar, Susan A.
name: Falany, Charles N.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: 1. Human cytosolic sulfotransferase 1B1 (SULT1B1) sulfates small phenolic compounds and bioactivates polycyclic aromatic hydrocarbons. To date, no SULT1B1 allelic variants have been well-characterized. 2. While cloning SULT1B1 from human endometrial specimens, an allelic variant resulting in valine instead of leucine at the 145th amino acid position (L145V) was detected. NCBI reported this alteration as the highest frequency SULT1B1 allelic variant. 3. L145V frequency comprised 9% of 37 mixed-population human patients and was specific to African Americans with an allelic frequency of 25%. Structurally, replacement of leucine with valine potentially destabilizes a conserved helix (α8) that forms the “floor” of both the substrate and PAPS binding domains. This destabilization results in altered kinetic properties including a four-fold decrease in affinity for PAP (3′, 5′-diphosphoadenosine). Kms for 3′-phosphoadenosine- 5′-phosphosulfate (PAPS) are similar; however, maximal turnover rate of the variant isoform (0.86 pmol/(min*μg)) is slower than wild-type (WT) SULT1B1 (1.26 pmol/(min*μg)). The L145V variant also displays altered kinetics toward small phenolic substrates, including a diminished p-nitrophenol Km and increased susceptibility to 1-naphthol substrate inhibition. 4. No significant correlation between genotype and prostate or colorectal cancer was observed in patients; however, the variant isoform could underlie specific pathologies in sub-Saharan African carriers.
The Bold and the Beautiful: Effects of Behavioural Traits and Glucocorticoids on Post-Translocation Survival in the Greater Stick-Nest Rat
Creators: name: Williams-Kelly, Kelly
Publisher: name: La Trobe
Year: 2024

description: Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Agriculture, Biomedicine and Environment, La Trobe University, Victoria, Australia.
Additional file 1: of PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma
Creators: name: Yang, Yan
name: Zhu, Jian
name: Zhang, Tiantian
name: Liu, Jing
name: Li, Yumei
name: Zhu, Yue
name: Xu, Lingjie
name: Wang, Rui
name: Su, Fang
name: Ou, Yurong
name: Wu, Qiong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: Virology

description: Table S1. The primers used for qRT-PCR analysis. (DOC 35 kb)
Metabolism of metofluthrin in rats: I. Identification of metabolites
Creators: name: Abe, Jun
name: Nagahori, Hirohisa
name: Tarui, Hirokazu
name: Tomigahara, Yoshitaka
name: Isobe, Naohiko
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: Computational Biology

description: 1. Metofluthrin (2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl (Z/E)-(1R)-trans-2,2-dimethyl-3-(1-propenyl)-cyclopropanecarboxylate) is a novel pyrethroid insecticide, which has E/Z isomers at prop-1-enyl group. 2. Rats were orally dosed with each [14C]-labelled E/Z isomer, and the excreta were collected for isolation and identification of metabolites. Analysis of the excreta by LC/MS and NMR revealed formation of 33 and 23 (total 42) metabolites from rats dosed with Z-isomer and E-isomer, respectively. 3. Major metabolic reactions were cleavage of ester linkage, O-demethylation, hydroxylation, epoxidation or reduction of double bond, glutathione conjugation and its further metabolism, hydroxylation of epoxide and formation of lactone ring. Notably, the acid side, 2,2-dimethyl-3-(1-propenyl)-cyclopropanecarboxylic acid, was much more variously metabolised compared to chrysanthemic acid, the acid side of the known pyrethroids. 4. Major metabolites for Z-isomer mostly retained ester linkage with 1,2-dihydroxypropyl group and/or 2-methylalcohol of cyclopropane ring, while most of those for E-isomer received hydrolysis of the ester linkage without oxidation at the 1-propenyl group or the gem-methyl groups, suggesting epoxidation and hydroxylation could occur more easily on Z-isomer. 5. As the novel metabolic pathways for pyrethroids, isomerisation of ω-carboxylic acid moiety, reduction or hydration of double bond and cleavage of cyclopropane ring via epoxidation were suggested.