cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Memory Paths : 8 December 2022
Creators: name: Lefrançois, Frédéric
name: Lérus, Ken
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Diaspora
subject: Caribbean
subject: Transamerica
subject: Migration
subject: Culture
subject: Heritage
subject: Memory
subject: Literature
subject: Anthropology
subject: FOS: Sociology
subject: Transmission
subject: https://memorypaths.sciencesconf.org/

description: Project Milestone of the International Cycle of Interdisciplinary Conferences
Self-similarity in the chemical evolution of galaxies and the delay time distribution of SNe Ia
Creators: name: Walcher, C. J.
name: Yates, R. M.
name: Minchev, I.
name: Chiappini, C.
name: Bergemann, M.
name: Bruzual, G.
name: Charlot, S.
name: Coelho, P. R. T.
name: Gallazzi, A.
name: Martig, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent improvements in the age dating of stellar populations and single stars allow us to study the ages and abundance of stars and galaxies with unprecedented accuracy. We here compare the relation between age and α-element abundances for stars in the solar neighborhood to that of local, early-type galaxies. We find both relations to be very similar. Both fall into two regimes with a flat slope for ages younger than ~9 Gyr and a steeper slope for ages older than that value. This quantitative similarity seems surprising, given the different types of galaxies and scales involved. For the sample of early-type galaxies we also show that the data are inconsistent with literature delay time distributions of either single or double Gaussian shape. The data are consistent with a power law delay time distribution. We thus confirm that the delay time distribution inferred for the Milky Way from chemical evolution arguments also must apply to massive early-type galaxies. We also offer a tentative explanation for the seeming universality of the age-[α/Fe] relation as the manifestation of averaging of different stellar populations with varying chemical evolution histories.
description: 8 pages, 3 figures, submitted to A&A, version in reply to first referee report
Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism.
Creators: name: Fedoryshchak, Roman O
name: Ocasio, Cory A
name: Strutton, Benjamin
name: Mattocks, Jo
name: Corran, Andrew J
name: Tate, Edward W
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: Chemical Biology & High Throughput
Biochemistry & Proteomics

description: Zymoseptoria tritici is the causative agent of Septoria tritici blotch (STB), which costs billions of dollars annually to major wheat-producing countries in terms of both fungicide use and crop loss. Agricultural pathogenic fungi have acquired resistance to most commercially available fungicide classes, and the rate of discovery and development of new fungicides has stalled, demanding new approaches and insights. Here we investigate a potential mechanism of targeting an important wheat pathogen Z. tritici via inhibition of N-myristoyltransferase (NMT). We characterize Z. tritici NMT biochemically for the first time, profile the in vivo Z. tritici myristoylated proteome and identify and validate the first Z. tritici NMT inhibitors. Proteomic investigation of the downstream effects of NMT inhibition identified an unusual and novel mechanism of defense against chemical toxicity in Z. tritici through the application of comparative bioinformatics to deconvolute function from the previously largely unannotated Z. tritici proteome. Research into novel fungicidal modes-of-action is essential to satisfy an urgent unmet need for novel fungicide targets, and we anticipate that this study will serve as a useful proteomics and bioinformatics resource for researchers studying Z. tritici.
An Analysis of the Correlation Between the Attitude, Belief, Opinion, and Demographic Components of Voluntary Forfeiture of One's Fourth Amendment Constitutional Right in Order to Permit Police Officers the use of New Concealed Weapons Detection Technology
Creators: name: Vann, Diane Hill Esq.
Publisher: name: Digital Repository at the University of Maryland
Year: 2002

description: The primary purpose of the study is to determine and analyze relationships between the major components of the participants' opinions, attitudes, and beliefs as to the effectiveness and willingness of individuals to voluntarily forfeit their Fourth Amendment Constitutional rights to permit the use of the new Concealed Weapons Detection Technology ("CWDT"). The new CWDT, as described in this study is capable of performing hands-off, non-intrusive body searches for contraband such as plastic explosives, drugs, and concealed weapons, specifically concealed guns. The study questions that Constitutionality of permitting police officers the use of such CWDT, and the Constitutionality of one's voluntary forfeiture of a Constitutional right to permit such use. Data collected for the study is from 100 residents of Madison, Wisconsin, and Washington, D.C., aged 18 years or older. The study analyzes Frequencies, Crosstabs, Chi Square, and Pearson's (r) and Spearman's (rs). The study although conducted before September 11, 2001, found that crime and terror remain great oppressors in the Nation, and that citizens are desparate for a resolution. The study reveals that the great majority of the study participants consider CWDT a positive solution.
Phosphorus-bearing molecules in solar-type star forming regions: First PO detection
Creators: name: Lefloch, B.
name: Vastel, C.
name: Viti, S.
name: Jimenez-Serra, I.
name: Codella, C.
name: Podio, L.
name: Ceccarelli, C.
name: Mendoza, E.
name: Lepine, J. R. D.
name: Bachiller, R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: As part of the Large Program ASAI (Astrochemical Surveys At IRAM), we have used the IRAM 30m telescope to lead a systematic search for the emission of rotational transitions of P-bearing species between 80 and 350 GHz towards L1157-B1, a shock position in the solar-type star forming region L1157. We report the detection of several transitions of PN and, for the first time, of prebiotic molecule PO. None of these species are detected towards the driving protostar of the outflow L1157-mm. Analysis of the line profiles shows that PN arises from the outflow cavity, where SiO, a strong shock tracer, is produced. Radiative transfer analysis yields an abundance of 2.5e-9 and 0.9e-9 for PO and PN, respectively. These results imply a strong depletion (approx 100) of Phosphorus in the quiescent cloud gas. Shock modelling shows that atomic N plays a major role in the chemistry of PO and PN. The relative abundance of PO and PN brings constraints both on the duration of the pre-shock phase, which has to be about 1 Myr, and on the shock parameters. The maximum temperature in the shock has to be larger than 4000K, which implies a shock velocity of 40 km/s.
description: 9 pages, 4 figures
Nanoscale Charge Balancing Mechanism in Alkali Substituted Calcium-Silicate-Hydrate Gels
Creators: name: Özçelik, V. Ongun
name: White, Claire E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Alkali-activated materials and related alternative cementitious systems are sustainable material technologies that have the potential to substantially lower CO$_2$ emissions associated with the construction industry. However, the impact of augmenting the chemical composition of the material on the main binder phase, calcium-silicate-hydrate gel, is far from understood, particularly since this binder phase is disordered at the nanoscale. Here, we reveal the presence of a charge balancing mechanism at the molecular level, which leads to stable structures when alkalis (i.e., Na or K) are incorporated into a calcium-silicate-hydrate gel, as modeled using crystalline 14Å tobermorite. These alkali containing charge balanced structures possess superior mechanical properties compared to their charge unbalanced counterparts. Our results, which are based on first-principles simulations using density functional theory, include the impact of charge balancing on the optimized geometries of the new model phases, formation energies, local bonding environments, bulk moduli and diffusion barriers of the alkali atoms within the crystals.
KFT - Handlungsempfehlung 07: Fallbeispiele zur besseren Abgrenzung von Aktivitäten unter Wasser von Sporttauchern (Freizeit) und (versicherten) Arbeitstätigkeiten von geprüften Forschungstaucher:innen
Creators: name: Kommission Forschungstauchen Deutschland E.V.
name: Verband Deutscher Sporttaucher E.V.
name: Berufsgenossenschaft Der Bauwirtschaft-Prävention
name: Unfallversicherung Bund Und Bahn
Publisher: name: Zenodo
Year: 2023
Subjects: Kommission Forschungstauchen Deutschland, Verband Deutscher Sporttaucher, Berufstauchen, Sporttauchen, geprüfte Forschungstaucher, Unfallversicherung

description: Die Aufstellung wurde als Handlungshilfe für wissenschaftliche Institute, tauchsportliche Verbände und Organisationen sowie für Behörden erarbeitet. Sie soll personalverantwortlichen Personen, die taucherische Tätigkeiten mitarbeitender Personen veranlassen, eine Hilfestellung bei der rechtlich belastbaren Durchführung von wissenschaftlichen Taucheinsätzen (etwa z. B. im Rahmen von Citizen Science-Projekten) geben. Die beispielhaft skizzierten Tauchgänge / Taucheinsätze wurden von einer gemeinsamen Arbeitsgruppe der Kommission Forschungstauchen Deutschland (KFT) und dem Verband Deutscher Sporttaucher (VDST), mit fachlicher Beratung durch die Deutsche gesetzliche Unfallversicherung (Berufsgenossenschaft der Bauwirtschaft - Prävention) und die Unfallversicherung Bund und Bahn, erarbeitet und basieren auf realitätsnahen Fallbeispielen aus der Praxis. Die Arbeitsgruppe erhebt keinen Anspruch auf Vollständigkeit der möglichen Varianten von Taucheinsätzen, noch ist die Zusammenstellung rechtlich bindend. Die Arbeitsgruppe weist zudem darauf hin, dass die letztendliche Verantwortung immer bei der Person liegt, welche die Taucheinsätze veranlasst und diese somit im Sinne der Gesetzgebung als / wie ein/e Unternehmer:in agiert. Die 5 Fallbeispiele stellen daher lediglich den “common sense” der o.g. Organisationen und der Unfallversicherungsträger dar. Die o.g. Organisationen weisen ausdrücklich auf die im beruflichen Arbeits- / Umweltschutz und der beruflichen Forschung / Wissenschaft vorhandenen arbeitsschutzrechtlichen Vorgaben der Deutschen gesetzlichen Unfallversicherung (DGUV-Regelwerke) für wissenschaftliche Tauchgänge (DGUV Regel 101-023 “Einsatz von Forschungstauchern”) hin.
Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe.
Creators: name: Panyain, Nattawadee
name: Godinat, Aurélien
name: Thawani, Aditya Raymond
name: Lachiondo-Ortega, Sofía
name: Mason, Katie
name: Elkhalifa, Sarah
name: Smith, Lisa M
name: Harrigan, Jeanine A
name: Tate, Edward W
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: Biochemistry & Proteomics
Chemical Biology & High Throughput

description: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme (DUB), is a potential drug target in various cancers, and liver and lung fibrosis. However, bona fide functions and substrates of UCHL1 remain poorly understood. Herein, we report the characterization of UCHL1 covalent inhibitor MT16-001 based on a thiazole cyanopyrrolidine scaffold. In combination with chemical proteomics, a closely related activity-based probe (MT16-205) was used to generate a comprehensive quantitative profile for on- and off-targets at endogenous cellular abundance. Both compounds are selective for UCHL1 over other DUBs in intact cells but also engage a range of other targets with good selectivity over the wider proteome, including aldehyde dehydrogenases, redox-sensitive Parkinson's disease related protein PARK7, and glutamine amidotransferase. Taken together, these results underline the importance of robust profiling of activity-based probes as chemical tools and highlight the cyanopyrrolidine warhead as a versatile platform for liganding diverse classes of protein with reactive cysteine residues which can be used for further inhibitor screening, and as a starting point for inhibitor development.
Complementarity via error-free measurement in a two-path interferometer
Creators: name: Liu, Yanjun
name: Lu, Jing
name: Zhou, and Lan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study both the wave-like behavior and particle-like behavior in a general Mach-Zehnder interferometer with its asymmetric beam splitter. A error-free measurement in the detector is used to extract the which-path information. The fringe visibility V and the which-path information Ipath are derived: their complementary relation V + Ipath less than or equal to 1 are found, and the condition for the equality is also presented.
description: 7 pages, 5 figures
VERGE in VBS 2023
Creators: name: Pantelidis, Nick
name: Andreadis, Stelios
name: Pegia, Maria
name: Moumtzidou, Anastasia
name: Galanopoulos, Damianos
name: Apostolidis, Konstantinos
name: Touska, Despoina
name: Gkountakos, Konstantinos
name: Gialampoukidis, Ilias
name: Vrochidis, Stefanos
name: Mezaris, Vasileios
name: Kompatsiaris, Ioannis
Publisher: name: Zenodo
Year: 2022

description: This paper describes VERGE, an interactive video retrieval system for browsing a collection of images from videos and searching for specific content. The system utilizes many retrieval techniques as well as fusion and reranking capabilities. A Web Application is also part of VERGE, where a user can create queries, view the top results and submit the appropriate data, all in a user-friendly way.
Meterwavelength Single-pulse Polarimetric Emission Survey
Creators: name: Mitra, Dipanjan
name: Basu, Rahul
name: Maciesiak, Krzysztof
name: Skrzypczak, Anna
name: Melikidze, George I.
name: Szary, Andrzej
name: Krzeszowski, Krzysztof
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We have conducted the Meterwavelength Single-pulse Polarimetric Emission Survey to study the radio emission properties of normal pulsars. A total of 123 pulsars with periods between 0.1 seconds and 8.5 seconds were observed in the survey at two different frequencies, 105 profiles at 333 MHz, 118 profiles at 618 MHz and 100 pulsars at both. In this work we concentrate primarily on the time-averaged properties of the pulsar emission. The measured widths of the pulsar profiles in our sample usually exhibit the radius to frequency mapping. We validate the existence of lower bounds for the distribution of profile widths with pulsar period ($P$), which is seen for multiple definitions of the width, viz. a lower boundary line (LBL) at $2.7^{\circ} P^{-0.5}$ with width measured at 50% level of profile peak, a LBL at $5.7^{\circ} P^{-0.5}$ for 10% level of peak and LBL at $6.3^{\circ} P^{-0.5}$ for width defined as 5$σ$ above the baseline level. In addition we have measured the degree of linear polarization in the average profile of pulsars and confirmed their dependence on pulsar spindown energy loss ($\dot{E}$). The single pulse polarization data show interesting trends with the polarization position angle (PPA) distribution exhibiting the simple rotating vector model for high $\dot{E}$ pulsars while the PPA becomes more complex for medium and low $\dot{E}$ pulsars. The single pulse total intensity data is useful for studying a number of emission properties from pulsars like subpulse drifting, nulling and mode changing which is being explored in separate works.
description: 31 pages, 6 figures, Accepted for publication in ApJ
Single-shot phase contrast microscopy using polarisation-resolved differential phase contrast.
Creators: name: Kalita, Ranjan
name: Flanagan, William
name: Lightley, Jonathan
name: Kumar, Sunil
name: Alexandrov, Yuriy
name: Garcia, Edwin
name: Hintze, Mark
name: Barkoulas, Michalis
name: Dunsby, Chris
name: French, Paul MW
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: Imaging

description: We present a robust, low-cost single-shot implementation of differential phase microscopy utilising a polarisation-sensitive camera to simultaneously acquire four images from which phase contrast images can be calculated. This polarisation-resolved differential phase contrast (pDPC) microscopy technique can be easily integrated with fluorescence microscopy.
A capillary flow model for discretely graded porous media in two phase heat transfer applications
Creators: name: Mooney, Joseph P.
name: Walsh, Patrick
name: PUNCH, JEFF
name: Egan, Vanessa
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 40
subject: Engineering

description: The ability to predict imbibition in porous media is important for our understanding of engineered systems such as heat pipes and vapour chambers. If the microstructure of the porous media, or wick, changes along its length, it can be termed a graded wick. Such graded wicks have been shown to exhibit enhanced performance in many engineered systems. However, accurate prediction models for imbibition within graded wicks are not fully developed but are essential for optimising designs to maximise potential enhancements. This deficit is addressed herein by developing a new analytical model for imbibition prediction in discretely graded porous media. Benchmark rate-of-rise experiments are first conducted in homogenous sintered copper particulate wicks using particle sizes of 40 µm, 70 µm, 100 µm and ≥ 250 µm. Two-layer graded particulate wicks of varying length ratios are also manufactured and tested in configurations with large particles followed by smaller particles and vice versa. Results obtained are used to validate the proposed model, and to quantify attainable enhancement/control of imbibition rates. The findings show very good agreement between measured and predicted data, with standard error ≤10%. Results are also validated in the context of previously published experimental data for homogeneous wicks. Findings for graded wicks show that imbibition rates are maximised when wicks are designed to have larger, 100− 250 µm, particles in permanently wetted sections of the wick and smaller, 70− 100 µm, particles in sections where the liquid/air interface is expected to reside. The relative length of graded wick layers is also shown to strongly influence obtainable enhancements over homogenous wicks. Imbibition rates were enhanced by ~21% for 78:22 length ratio graded wicks, and >175% for 95:5 length ratio graded wicks. Alternatively, imbibition can be controlled by tailoring the sizes of particles used in different sections of the wick. This is useful for applications requiring maximized flow control, such as gravity opposing heat pipes or vapor chambers. Overall, the findings of this study help with understanding imbibition in graded wick structures and provide a validated prediction model that aids the design of improved graded wicks for engineered applications.
Formation of spin droplet at nu = 5/2 in an asymmetric quantum dot under quantum Hall conditions
Creators: name: Atci, H.
name: Siddiki, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this work, a quantum dot that is defined asymmetrically by electrostatic means induced on a GaAs/AlGaAs heterostructure is investigated to unravel the effect of geometric constrains on the formation of spin droplets under quantised Hall conditions. The incompressibility of exciting nu = 5/2 state is explored by solving the Schrodinger equation within spin density functional theory, where the confinement potential is obtained self-consistently utilising the Thomas-Fermi approximation. Our numerical investigations show that the spatial distribution of the nu = 2 incompressible strips and electron occupation in the second lowest Landau level considerably differ from the results of the laterally symmetric quantum dots. Our findings yield two important consequences, first the incompressibility of the intriguing nu = 5/2 state is strongly affected by the asymmetry, and second, since the Aharonov-Bohm interference patterns depend on the velocity of the particles, asymmetry yields an additional parameter to adjust the oscillation period, which imposes a boundary condition dependency in observing quasi-particle phases.
description: 7 pages, 8 figures
Neutron tomography of magnetic Majorana fermions in a proximate quantum spin liquid
Creators: name: Banerjee, Arnab
name: Yan, Jiaqiang
name: Knolle, Johannes
name: Bridges, Craig A.
name: Stone, Matthew B.
name: Lumsden, Mark D.
name: Mandrus, David G.
name: Tennant, David A.
name: Moessner, Roderich
name: Nagler, Stephen E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Quantum matter provides an effective vacuum out of which arise emergent particles not corresponding to any experimentally detected elementary particle. Topological quantum materials in particular have become a focus of intense research in part because of the remarkable possibility to realize Majorana fermions, with their potential for new, decoherence-free quantum computing architectures. In this paper we undertake a study on high-quality single crystal of $α-RuCl_3$ which has been identified as a material realizing a proximate Kitaev state, a topological quantum state with magnetic Majorana fermions. Four-dimensional tomographic reconstruction of dynamical correlations measured using neutrons is uniquely powerful for probing such magnetic states. We discover unusual signals, including an unprecedented column of scattering over a large energy interval around the Brillouin zone center which is remarkably stable with temperature. This is straightforwardly accounted for in terms of the Majorana excitations present in Kitaev's topological quantum spin liquid. Other, more delicate, features in the scattering can be transparently associated with perturbations to an ideal model. This opens a window on emergent magnetic Majorana fermions in correlated materials.
description: 10 pages main text with 4 main figures, 13 Supplementary pages with 9 figures
Gluon Sivers function in a light-cone spectator model
Creators: name: Lu, Zhun
name: Ma, Bo-Qiang
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We calculate the gluon Sivers function of the proton in the valence-$x$ region using a light-cone spectator model with the presence of the gluon degree of freedom. We obtain the values of the parameters by fitting the model resulting gluon density distribution to the known parametrization. We find that our results agree with the recent phenomenological extraction of the gluon Sivers function after considering the evolution effect. We also estimate the mean transverse momentum of the gluon in a transversely polarized proton and find that it is within the range implied by the Burkardt sum rule.
description: 7 pages, 4 figures, to appear in Physical Review D
Power-law modulation of the scalar power spectrum from a heavy field with a monomial potential
Creators: name: Huang, Qing-Guo
name: Pi, Shi
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The effects of heavy fields modulate the scalar power spectrum during inflation. We analytically calculate the modulations of the scalar power spectrum from a heavy field with a separable monomial potential, i.e. V(ϕ)~ϕ^n. In general the modulation is characterized by a power-law oscillation which is reduced to the logarithmic oscillation in the case of n=2.
description: 18 pages, 1 figure
Meterwavelength Single-pulse Polarimetric Emission Survey II: The phenomenon of Drifting Subpulses
Creators: name: Basu, Rahul
name: Mitra, Dipanjan
name: Melikidze, George I.
name: Maciesiak, Krzysztof
name: Skrzypczak, Anna
name: Szary, Andrzej
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A large sample of pulsars was observed as part of the Meterwavelength Single-pulse Polarimetric Emission Survey. We carried out a detailed fluctuation spectral analysis which revealed periodic features in 46% pulsars including 22 pulsars where drifting characteristics were reported for the first time. The pulsar population can be categorized into three distinct groups, pulsars which show systematic drift motion within the pulse window, the pulsars showing no systematic drift but periodic amplitude fluctuation and pulsars with no periodic variations. We discovered the dependence of the drifting phenomenon on the spin down energy loss ($\dot{E}$), with the three categories occupying distinctly different regions along the $\dot{E}$ axis. The estimation of the drift periodicity ($P_3$) from the peak frequency in the fluctuation spectra is ambiguous due to the aliasing effect. However, using basic physical arguments we were able to determine $P_3$ in pulsars showing systematic drift motion. The estimated $P_3$ values in these pulsars were anti-correlated with $\dot{E}$ which favoured the Partially Screened Gap model of Inner Acceleration Region in pulsars.
description: 33 Pages, 11 figures, accepted for publication in ApJ
Hitting the right note at the right time: Circadian control of audibility in Anopheles mosquito mating swarms is mediated by flight tones.
Creators: name: Somers, Jason
name: Georgiades, Marcos
name: Su, Matthew P
name: Bagi, Judit
name: Andrés, Marta
name: Alampounti, Alexandros
name: Mills, Gordon
name: Ntabaliba, Watson
name: Moore, Sarah J
name: Spaccapelo, Roberta
name: Albert, Joerg T
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Ecology,Evolution & Ethology
subject: Neurosciences
subject: FOS: Clinical medicine

description: [Figure: see text].
D4.1 Annotation guidelines
Creators: name: Kreuzthaler, Markus
name: Collins, Kris
name: Schulz, Stefan
name: Kankainen, Kristian
name: De Zegher, Isabelle
Publisher: name: Zenodo
Year: 2023
Subjects: manual annotation tools
manual annotation guidelines

description: Manual annotations of clinical narratives are crucial for the adoption and evaluation of NLP tools, which support an overall AI assisted data curation approach within the AIDAVA project. In the preparation phase - in scope of this deliverable - for the Task “T4.3 Manual Annotation of text documents in 3 languages”, and based on the data elements identified for the use cases cross border breast cancer patient registries, and longitudinal individual health records for patients at risk of sudden cardiac arrest, requirements for the manual annotation tool have been formulated. Grounded on the requirement analysis, INCEpTION was chosen to support the manual annotation task. A first manual annotation schema was developed and tested, with a focus on the use of SNOMED CT and FHIR for the normalized form of the entity types of interest. A first version of the annotation guidelines is drafted in this document and will be revised in close cooperation with the manual annotators at the three different clinical sides (Med Uni Graz with MUG, Northern Estonian Medical Center with NEMC, Maastricht Medical University Center with UM), AVER and ONTO during the piloting phase until Q1 2023.
Improving Twitter Sentiment Classification via Multi-Level Sentiment-Enriched Word Embeddings
Creators: name: Xiong, Shufeng
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Most of existing work learn sentiment-specific word representation for improving Twitter sentiment classification, which encoded both n-gram and distant supervised tweet sentiment information in learning process. They assume all words within a tweet have the same sentiment polarity as the whole tweet, which ignores the word its own sentiment polarity. To address this problem, we propose to learn sentiment-specific word embedding by exploiting both lexicon resource and distant supervised information. We develop a multi-level sentiment-enriched word embedding learning method, which uses parallel asymmetric neural network to model n-gram, word level sentiment and tweet level sentiment in learning process. Experiments on standard benchmarks show our approach outperforms state-of-the-art methods.
Dominating and Irredundant Broadcasts in Graphs
Creators: name: Mynhardt, Kieka
name: Roux, Riana
Publisher: name: arXiv
Year: 2016
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C69

description: A broadcast on a nontrivial connected graph G=(V,E) is a function f from V(G) to {0,1,...,diam(G)} such that f(v) does not exceed the eccentricity of v. The cost of f is the sum of the function values. A broadcast f is dominating if each vertex of G is at distance at most f(v) from a vertex v with positive f(v). We use properties of minimal dominating broadcasts to define the concept of an irredundant broadcast on G. We determine conditions under which an irredundant broadcast is maximal irredundant. Denoting the minimum costs of dominating and maximal irredundant broadcasts by gamma_{b}(G) and ir_{b}(G) respectively, the definitions imply that ir_{b}(G) is bounded above by gamma_{b}(G) for all graphs. We show that gamma_{b} in turn is bounded above by (5/4)ir_{b}(G) for all graphs G. We also briefly consider the upper broadcast number Gamma_{b}(G) and upper irredundant broadcast number IR_{b}(G), and illustrate that the ratio IR_{b} to Gamma_{b} is unbounded for general graphs.
description: 19 pages, 9 figures
Real-world safety of nusinersen in Japan: results from an interim analysis of a post-marketing surveillance and safety database
Creators: name: Wataya, Takafumi
name: Takasaki, Sakura
name: Hoshino, Misuzu
name: Makioka, Haruki
name: Nakamura, Genshu
name: Matsuda, Naoto
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Nusinersen is the first disease-modifying therapy to treat spinal muscular atrophy (SMA). This report describes the safety and effectiveness of nusinersen in Japanese clinical use using two data sources: an ongoing Japanese post-marketing surveillance (PMS) and the safety database of the marketing authorisation holder, Biogen . The PMS is evaluating the safety and effectiveness of nusinersen in all patients treated with nusinersen in Japan between August 2017 and August 2025; this interim analysis included data up to May 30, 2019. Biogen safety database data up to June 30, 2019 were also included to capture adverse events (AEs) from after the interim analysis cutoff date. Collected data included medical history, dosage and administration, and AEs. Safety assessment included AEs and serious AEs (SAEs). Effectiveness analyses included motor function assessments and clinical global impressions of improvement. Of 271 patients in the PMS population, 94 had SMA type I (34.7%), and 177 had SMA types II–IV (65.3%). AEs occurred in 67 patients (24.7%) and SAEs in 23 patients (8.5%). The Biogen safety database contained reports of 345 AEs; the most common were pneumonia, headache, and pyrexia, consistent with symptoms of SMA and lumbar puncture. In the analysis set, 26.2% of patients receiving nusinersen showed motor function improvements and 99.6–100.0% showed overall improvement. In this interim analysis of the PMS and Biogen safety database, nusinersen had a favourable benefit–risk profile in Japanese patients with SMA.
The Impact of a Theory Practice Based Professionalization Program on Student Teachers’ Knowledge and Beliefs
Creators: name: Souvignier, Elmar
name: Ehlert, Mareike
name: Förster, Natalie
name: Mentel, Henrike
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Teacher Education and Professional Development
subject: Education

description: Preregistration of the manuscript "The Impact of a Theory Practice Based Professionalization Program on Student Teachers’ Knowledge and Beliefs"
Influence of interstitial Fe to the phase diagram of Fe$_{1+y}$Te$_{1-x}$Se$_x$ single crystals
Creators: name: Sun, Yue
name: Yamada, Tatsuhiro
name: Pyon, Sunseng
name: Tamegai, Tsuyoshi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Superconductivity (SC) with the suppression of long-range antiferromagnetic (AFM) order is observed in the parent compounds of both iron-based and cuprate superconductors. The AFM wave vectors are bicollinear ($π$, 0) in the parent compound FeTe different from the collinear AFM order ($π$, $π$) in most iron pnictides. Study of the phase diagram of Fe$_{1+y}$Te$_{1-x}$Se$_x$ is the most direct way to investigate the competition between bicollinear AFM and SC. However, presence of interstitial Fe affects both magnetism and SC of Fe$_{1+y}$Te$_{1-x}$Se$_x$, which hinders the establishment of the real phase diagram. Here, we report the comparison of doping-temperature ($x$-$T$) phase diagrams for Fe$_{1+y}$Te$_{1-x}$Se$_x$ (0 $\leq$ $x$ $\leq$ 0.43) single crystals before and after removing interstitial Fe. Without interstitial Fe, the AFM state survives only for $x$ $
description: 20 pages, 6 figures
Understanding the unmet needs in insomnia treatment: a systematic literature review of real-world evidence
Creators: name: Campbell, Renee
name: Chabot, Isabelle
name: Rousseau, Ben
name: Bridge, Daisy
name: Nicol, Gillian
name: Meier, Genevieve
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
classificationCode: 111714
subject: Mental Health
subject: Hematology
classificationCode: 110309
subject: Infectious Diseases
subject: FOS: Health sciences

description: The objective of this study was to define and characterize the unmet needs in the pharmacological management of insomnia. A systematic literature review was conducted to identify relevant literature reporting real-world evidence in insomnia, published from January 2009 to April 2020. Pharmacological treatments – both prescription (benzodiazepines, ‘Z-drugs’ and suvorexant) and off-label (antidepressants, antipsychotics, and antihistamines) – were considered. Overall, 108 publications describing the humanistic (n = 59) and economic burden (n = 20) of insomnia, off-label treatment patterns (n = 28) and factors influencing treatment adherence or persistence (n = 8) were identified. A high prevalence of comorbid conditions was reported in patients with insomnia resulting in significantly lower health-related QoL compared to those with insomnia or a comorbidity alone. Current treatment options were associated with adverse events, including reduced sleep quality and next-day somnolence. An increased risk of accidents/injuries was also associated with insomnia and its treatment. Furthermore, safety concerns and perceived lack of efficacy for approved treatments have led to frequent off-label prescribing, despite a lack of clinical evidence of risk/benefit ratios. Safety concerns associated with benzodiazepines include risk of dependence, leading to prolonged treatment persistence and exacerbated adverse events, making them unsuitable for use in patients with chronic insomnia. Finally, the substantial economic burden of insomnia was evident, with reduced work productivity demonstrated in patients with insomnia compared to the general population. This review highlights a clear unmet need for insomnia therapies that improve sleep quality without resulting in next-day impairment and/or dependence.
Infections in the developing brain: The role of the neuro-immune axis
Creators: name: Kim, John
name: Erice, Clara
name: Rohlwink, Ursula K
name: Tucker, Elizabeth W
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Infectious Disease
subject: Neurosciences
subject: FOS: Clinical medicine

description: Central nervous system (CNS) infections occur more commonly in young children than in adults and pose unique challenges in the developing brain. This review builds on the distinct vulnerabilities in children's peripheral immune system (outlined in part 1 of this review series) and focuses on how the developing brain responds once a CNS infection occurs. Although the protective blood-brain barrier (BBB) matures early, pathogens enter the CNS and initiate a localized innate immune response with release of cytokines and chemokines to recruit peripheral immune cells that contribute to the inflammatory cascade. This immune response is initiated by the resident brain cells, microglia and astrocytes, which are not only integral to fighting the infection but also have important roles during normal brain development. Additionally, cytokines and other immune mediators such as matrix metalloproteinases from neurons, glia, and endothelial cells not only play a role in BBB permeability and peripheral cell recruitment, but also in brain maturation. Consequently, these immune modulators and the activation of microglia and astrocytes during infection adversely impact normal neurodevelopment. Perturbations to normal brain development manifest as neurodevelopmental and neurocognitive impairments common among children who survive CNS infections and are often permanent. In part 2 of the review series, we broadly summarize the unique challenges CNS infections create in a developing brain and explore the interaction of regulators of neurodevelopment and CNS immune response as part of the neuro-immune axis.
Two-dimensional light-front $ϕ^4$ theory in a symmetric polynomial basis
Creators: name: Burkardt, M.
name: Chabysheva, S. S.
name: Hiller, J. R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the lowest-mass eigenstates of $ϕ^4_{1+1}$ theory with both odd and even numbers of constituents. The calculation is carried out as a diagonalization of the light-front Hamiltonian in a Fock-space representation. In each Fock sector a fully symmetric polynomial basis is used to represent the Fock wave function. Convergence is investigated with respect to the number of basis polynomials in each sector and with respect to the number of sectors. The dependence of the spectrum on the coupling strength is used to estimate the critical coupling for the positive-mass-squared case. An apparent discrepancy with equal-time calculations of the critical coupling is resolved by an appropriate mass renormalization.
description: 18 pages, 8 figures, RevTeX 4.1
Algebraic Multigrid Preconditioners for Multiphase Flow in Porous Media
Creators: name: Bui, Quan M.
name: Elman, Howard C.
name: Moulton, J. D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Multiphase flow is a critical process in a wide range of applications, including carbon sequestration, contaminant remediation, and groundwater management. Typically, this process is modeled by a nonlinear system of partial differential equations derived by considering the mass conservation of each phase (e.g., oil, water), along with constitutive laws for the relationship of phase velocity to phase pressure. In this study, we develop and study efficient solution algorithms for solving the algebraic systems of equations derived from a fully coupled and time-implicit treatment of models of multiphase flow. We explore the performance of several preconditioners based on algebraic multigrid (AMG) for solving the linearized problem, including "black-box" AMG applied directly to the system, a new version of constrained pressure residual multigrid (CPR-AMG) preconditioning, and a new preconditioner derived using an approximate Schur complement arising from the block factorization of the Jacobian. We show that the new methods are the most robust with respect to problem character as determined by varying effects of capillary pressures, and we show that the block factorization preconditioner is both efficient and scales optimally with problem size.
Development of a ReaxFF Reactive Force Field for ternary phosphate-based bioactive glasses: input and analysis codes
Creators: name: Fallah, Zohreh
name: Christie, Jamieson
Publisher: name: Loughborough University
Year: 2023

description: Input and analysis codes to accompany the paper "Development of a ReaxFF Reactive Force Field for ternary phosphate-based bioactive glasses". Not all output files are included for space reasons, but the files given are sufficient to reproduce the methodology in the paper.Abstract of paper:Phosphate-based glasses (PBGs) in the CaO-Na2O-P2O5 system have diverse applications as biomaterials due to their unique dissolution properties. A reactive force field (ReaxFF) has been developed to simulate these materials at the atomic level. The ReaxFF parameters of PBGs, including the interaction between phosphorus and calcium atoms, have been developed using a published code based on genetic algorithms. The training data, including the atomic charges, atomic forces, bond and angle parameters and different differential energies are chosen and measured from static quantum-mechanical calculations and ab initio molecular dynamics of PBGs. We did different short- and medium-range structural analysis on the bulk simulated PBGs with different compositions to validate the developed potential. Radial and angular distribution functions and coordination numbers of network formers and modifiers as well as the network connectivity of the bioglass are in agreement with experimental and previous simulations using both shell-model classical force fields and ab initio simulated data; for example, the coordination number of phosphorus is 4.0. This successful development of ReaxFF parameters being able to describe the bulk PBGs enables us to work on dissolution behaviour of the glasses including the interaction of water molecules with PBGs in future works.
Open clusters and associations in the Gaia era
Creators: name: Moraux, E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Open clusters and associations are groups of young stars, respectively bound and unbound, that share the same origin and disperse over time into the galactic field. As such, their formation and evolution are the key to understand the origin and properties of galactic stellar populations. Moreover, since their members have about the same age, they are ideal laboratories to study the properties of young stars and constrain stellar evolution theories. In this contribution, I present our current knowledge on open clusters and associations. I focus on the methods used to derive the statistical properties (IMF, spatial distribution, IMF) of young stars and briefly discuss how they depend on the environment. I then describe how open clusters can be used as probes to investigate the structure, dynamics and chemical composition of the Milky Way. I conclude by presenting the Gaia mission and discuss how it will revolutionize this field of research.
description: To appear in EES2015 - Stellar Clusters: benchmarks of stellar physics and galactic evolution, Eds. E. Moraux, Y. Lebreton and C. Charbonnel, EAS Publications Series. arXiv admin note: text overlap with arXiv:0911.1459, arXiv:1512.03658, arXiv:1512.06854, arXiv:1505.08027, arXiv:1307.0569, arXiv:astro-ph/0509804, arXiv:1511.08884, arXiv:1602.07121, arXiv:1104.2182 by other authors
DESENVOLVIMENTO PROFISSIONAL DE PROFESSORES DE HISTÓRIA MEDIADO PELAS TECNOLOGIAS DIGITAIS
Creators: name: FERREIRA, ANDRÉIA DE ASSIS
Publisher: name: Zenodo
Year: 2023
Subjects: desenvolvimento profissional do professor de História
grupo de trabalho colaborativo
tecnologias de informação e comunicação aplicadas à educação

description: Esse ebook faz parte da tese de doutorado defendida em 2010, no programa de pós-graduação em Educação, da Universidade Federal de Minas Gerais.
Developing a talent management framework for domestically and internationally trained nurses and midwives in healthcare organizations: A mixed-methods research protocol
Creators: name: BERKERY, ELAINE
name: RYAN, NUALA
name: O'Malley, Bernadette
name: PURTILL, HELEN
name: O'DONNELL, CLAIRE
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 49
subject: Mathematical sciences
classificationCode: 3506
subject: Marketing
subject: FOS: Economics and business

description: Aim: The aim of this study is to gather evidence on talent management practices for nurses and midwives in an Irish hospital group, to identify any shortcomings in the current practices and to develop an evidence-based talent management framework for the hospital group.Design: This paper details a protocol for a mixed methods research study that will be used to (1) identify, critically evaluate and summarize academic scholarship on talent management strategies for both domestically and internationally trained nurses and midwives, leading to the development of a model of talent management for this study, (2) gather evidence from both domestic and internationally trained nurses and mid-wives, via questionnaires and focus groups within the hospital group on current talent management practices and (3) use the model previously developed to organize our findings and develop a talent management framework for the hospital group.Methods: The study will adapt a mixed methods approach. Quantitative data will be analysed using SPSS, and qualitative data will be analysed using NVivo.Results: Our findings will support a stakeholder approach to the development of talent management practices for both domestic and internationally trained nurses and midwives in healthcare organizations. Doing so should improve the pipeline of suitably qualified nurses and midwives for future roles, by assisting nurses and midwives to identify career paths and future educational opportunities. From an organizational perspective, this research will allow healthcare organizations to adapt their current workforce planning strategies, tailoring them to the needs of the current workforce, which should reduce turnover, ensuring a highly skilled workforce, with the appropriate numbers to provide the care required within that healthcare setting.No Patient of Public Contribution: Contributions will be sought from nursing and mid-wifery staff and management within the hos