cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Probing dynamical processes in the planet forming region with dust mineralogy
Creators: name: McClure, M. K.
name: Manoj, P.
name: Calvet, N.
name: Adame, L.
name: Espaillat, C.
name: Watson, D. M.
name: Sargent, B.
name: Forrest, W. J.
name: D'Alessio, P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present Herschel Space Observatory PACS spectra of GQ Lup, a protoplanetary disk in the Lupus star-forming region. Through SED fitting from 0.3μm to 1.3mm, we construct a self-consistent model of this system's temperature and density structures, finding that although it is 3 Myr old, its dust has not settled to the midplane substantially. The disk has a radial gradient in both the silicate dust composition and grain size, with large amorphous grains in the upper layers of the inner disk and an enhancement of submicron, crystalline grains in the outer disk. We detect an excess of emission in the Herschel PACS B2A band near 63μm and model it with a combination of {\sim}15 to 70μm crystalline water ice grains with a size distribution consistent with ice recondensation-enhanced grain growth and a mass fraction half of that of our solar system. The combination of crystalline water ice and silicates in the outer disk is suggestive of disk-wide heating events or planetesimal collisions. If confirmed, this would be the first detection of water ice by Herschel.
description: 8 pages, 3 figures, 1 table, accepted to ApJ Letters
Hans Hermas Überlegungen zur Bildhaftigkeit des Films im Vergleich mit anderen Darstellungsformen -- Vorstellung einer Arbeit aus den Forschungen zum Film am Wiener Institut für Psychologie in den 1930er Jahren
Creators: name: Czwik, Maria
Publisher: name: Zenodo
Year: 2021

description: This chapter examines the doctoral dissertation of Hans Herma (Johann/John
 Leopold Herman, * 1911 in Wien, † 1966 in New York), Die Bildhaftigkeit des Films. This
 dissertation was part of an extensive research program at the Vienna Institute for
 Psychology in the 1930s. Herma’s work focused on a specific aspect of film: its
 ability to take the viewer out of their immediate perceptual environment and place
 them in the scene represented by the film. According to Herma, film goes beyond
 the deictic possibilites of a novel through its ability to offer an ad oculos
 demonstration. Taking the pictorial character of film as his starting point, Herma provides in
 his dissertation a detailed and empirically based description of the perceptual
 psychological foundations of film and how they interact with the technical features of
 the medium.
Weak Interaction Studies with 6He
Creators: name: Knecht, A.
name: Alexander, Z. T.
name: Bagdasarova, Y.
name: Cope, T. M.
name: Delbridge, B. G.
name: Flechard, X.
name: Garcia, A.
name: Hong, R.
name: Lienard, E.
name: Mueller, P.
name: Naviliat-Cuncic, O.
name: Palmer, A. S. C.
name: Robertson, R. G. H.
name: Storm, D. W.
name: Swanson, H. E.
name: Utsuno, S.
name: Wauters, F.
name: Williams, W.
name: Wrede, C.
name: Zumwalt, D. W.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The 6He nucleus is an ideal candidate to study the weak interaction. To this end we have built a high-intensity source of 6He delivering ~10^10 atoms/s to experiments. Taking full advantage of that available intensity we have performed a high-precision measurement of the 6He half-life that directly probes the axial part of the nuclear Hamiltonian. Currently, we are preparing a measurement of the beta-neutrino angular correlation in 6He beta decay that will allow to search for new physics beyond the Standard Model in the form of tensor currents.
description: 5 pages, 4 figures, proceedings for the Eleventh Conference on the Intersections of Particle and Nuclear Physics (CIPANP 2012)
A static axisymmetric exact solution of $f(R)$-gravity
Creators: name: Gutierrez-Pineres, Antonio C.
name: Lopez-Monsalvo, Cesar S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present an exact, axially symmetric, static, vacuum solution for $f(R)$ gravity in Weyl's canonical coordinates. We obtain a general explicit expression for the dependence of $df(R)/dR$ upon the $r$ and $z$ coordinates and then the corresponding explicit form of $f(R)$, which must be consistent with the field equations. We analyze in detail the modified Schwarzschild solution in prolate spheroidal coordinates. Finally, we study the curvature invariants and show that, in the case of $f(R)\neq R$, this solution corresponds to a naked singularity.
description: To be published in Physics Letters B. Replaced with minor changes to match published version
Das nichtsprachliche Darstellungsmittel Film – Diskussionen am Wiener Psychologischen Institut. Kommentar zu Maria Czwik
Creators: name: Friedrich, Janette
Publisher: name: Zenodo
Year: 2021

description: Commentary on "Hans Hermas Überlegungen zur Bildhaftigkeit des Films im Vergleich mit anderen Darstellungsformen -- Vorstellung einer Arbeit aus den Forschungen zum Film am Wiener Institut für Psychologie in den 1930er Jahren" (https://zenodo.org/record/5142284)
3D Face Recognition using Significant Point based SULD Descriptor
Creators: name: Shekar, B. H.
name: Harivinod, N.
name: Kumari, M. Sharmila
name: Holla, K. Raghurama
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this work, we present a new 3D face recognition method based on Speeded-Up Local Descriptor (SULD) of significant points extracted from the range images of faces. The proposed model consists of a method for extracting distinctive invariant features from range images of faces that can be used to perform reliable matching between different poses of range images of faces. For a given 3D face scan, range images are computed and the potential interest points are identified by searching at all scales. Based on the stability of the interest point, significant points are extracted. For each significant point we compute the SULD descriptor which consists of vector made of values from the convolved Haar wavelet responses located on concentric circles centred on the significant point, and where the amount of Gaussian smoothing is proportional to the radii of the circles. Experimental results show that the newly proposed method provides higher recognition rate compared to other existing contemporary models developed for 3D face recognition.
Shadows of Multi-Black Holes: Analytic Exploration
Creators: name: Yumoto, Akifumi
name: Nitta, Daisuke
name: Chiba, Takeshi
name: Sugiyama, Naoshi
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Shadows of multi-black holes have structures distinct from the mere superposition of the shadow of a single black hole: the eyebrow-like structures outside the main shadows and the deformation of the shadows. We present analytic estimates of these structures using the static multi-black hole solution (Majumdar-Papapetrou solution). We show that the width of the eyebrow is related with the distance between the black holes and that the shadows are deformed into ellipses due to the presence of the second black holes. These results are helpful to understand qualitatively the features of the shadows of colliding black holes. We also present the shadows of colliding/coalescing black holes in the Kastor-Traschen solution.
description: 15 pages, 11 figures, to appear in Phys. Rev. D
Some multiplicity adjustment procedures for clinical trials with sequential design and multiple endpoints
Creators: name: Luo, Xiaodong
name: Quan, Hui
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: This paper proposes some new multiplicity adjustment procedures for clinical trials with multiple endpoints and multiple interim analyses. The proposed sequential procedures, adapting the popular multiple comparison procedures for fixed time-point design and utilizing α-spending for each endpoint, are shown to strongly control the family-wise type-1 error rate and provide powerful yet versatile multiplicity adjustment solutions for monitoring multiple endpoints via interim analyses.
asreview-simulation
Creators: name: Spaaks, Jurriaan H.
name: Soares Siqueira, Abel
Publisher: name: Zenodo
Year: 2024
Subjects: Automated Systematic Review
ASReview
NLP
Natural Language Processing
AI
CLI
hyperparameters

description: Command line interface to simulate an ASReview analysis using a variety of classifiers, feature extractors, queriers, and balancers, which can all be configured to run with custom parameterizations.
title: Rechtfertigungskrise der sozialen Marktwirtschaft und Global Justice: Voraussetzungen einer sozialen Globalisierung?
Creators: name: Grusser, Gerald
Publisher: name: Universität Erfurt
Year: 2019
Subjects: subject: soziale Marktwirtschaft
subject: global justice
subject: Globalisierung
subject: 330
subject: 340

description: Tagungsberichte, vol. 4(2018)
Perception, awareness, and film practice: A natural history of the "Doris Film"
Creators: name: Engelke, Henning
Publisher: name: Zenodo
Year: 2021

description: This chapter takes a close look at the film at the center of the influential
 interaction research project the Natural History of an Interview. The film, commonly
 known under the alias of its main character “Doris”, was made in May 1956 by
 the anthropologist and cybernetician Gregory Bateson and the cinematographer
 David Myers. It was subsequently studied in detail by an interdisciplinary group
 of psychiatrists, linguists, and anthropologists brought together by the psychiatrist
 Frieda Fromm-Reichmann. Tracing the film’s production history and analyzing its
 cinematic techniques, this chapter considers the film’s integration into emerging
 research procedures, documentary film practices, and experimental film discourse.
 It is argued that the film formed a transitional object, marking a turning point in
 approaches to research filming, but also a critical intersection between research
 film, communication theory, and emerging observational styles in documentary
 film.
Rotation measure synthesis at the 2 m wavelength of the FAN region: Unveiling screens and bubbles
Creators: name: Iacobelli, Marco
name: Haverkorn, Marijke
name: Katgert, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Rotation Measure synthesis (RM synthesis) of the Westerbork Synthesis Radio Telescope (WSRT) observations at 2 m wavelength of the FAN region at l=137deg, b=+7deg shows the morphology of structures in the ionized interstellar medium. We interpret the diffuse polarized synchrotron emission in terms of coherent structures in the interstellar medium and the properties of the interstellar magnetic field. For the first time, cross-correlation is applied to identify and characterize polarized structures in Faraday depth space. Complementary information about the medium are derived from H$α$ emission, properties of nearby pulsars, and optical polarized starlight measurements. Three morphological patterns are recognized, showing structures on scales from degrees down to the beam size. At low Faraday depth values, a low gradient across the imaged field is detected, almost aligned with the Galactic plane. Power spectra of polarized structures in Faraday depth space provide evidence of turbulence. A sign reversal in Faraday depth space indicates a reversal of the magnetic field component along the line of sight, from towards the observer and nearby to away from the observer at larger distances. The distance to the nearby, extended component is estimated to be lesser than 100 pc, which suggests that this structure corresponds to the Local Bubble wall. For the circular component, various physical interpretations are discussed. The most likely explanation is that the circular component seems to be the presence of a nearby (about 200 pc away) relic Stromgren sphere, associated with an old unidentified white dwarf star and expanding in a low-density environment.
description: 16 pages, 16 figures, 4 tabs, accepted for publication in A&A
Index to Minutes of Meetings of the Executive Committee & the Board of Trustees, 1911-1946, "L"
Creators: name: Carnegie Corporation Of New York
Publisher: name: Columbia University
Year: 2018
Subjects: Corporate meetings
Charitable uses, trusts, and foundations

description: The following microfilm is a copy of 5 x 8 Kardex cards hitherto used in the Cumulative Index to the Minutes of the Executive Committee and of the Board of Trustees of the Carnegie Corporation of New York, from the first meeting of the Trustees (November 10, 1911) through the 22nd meeting of the Executive Committee (September 17, 1946). The Cumulative Index was initiated during the early days of the Corporation when the offices of the President, the Secretary, and the Treasurer were separately organized, each with its own system of records. It was maintained by Durand R. Miller, first as secretary to the Secretary of the Corporation, James Bertram, and later as Record Clerk of the Corporation. The entries in the Cumulative Index are duplications of those recorded in the index of each bound volume of Minutes.
Dynamical polarizability of atoms in arbitrary light fields: general theory and application to cesium
Creators: name: Kien, Fam Le
name: Schneeweiss, Philipp
name: Rauschenbeutel, Arno
Publisher: name: arXiv
Year: 2012
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a systematic derivation of the dynamical polarizability and the ac Stark shift of the ground and excited states of atoms interacting with a far-off-resonance light field of arbitrary polarization. We calculate the scalar, vector, and tensor polarizabilities of atomic cesium using resonance wavelengths and reduced matrix elements for a large number of transitions. We analyze the properties of the fictitious magnetic field produced by the vector polarizability in conjunction with the ellipticity of the polarization of the light field.
description: see also Supplemental Material
Begonia micranthera var. venturii L. B. Sm. & B. G. Schub
Creators: name: Moonlight, Peter
name: Fuentes, Alfredo F.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Cucurbitales
Begoniaceae
Begonia
Begonia micranthera
Begonia micranthera var. venturii l.b.sm. & b.g.schub

description: Begonia micranthera var. venturii L.B.Sm. & B.G.Schub, Darwiniana 4: 97 (1941b).
R.C. Foster, Contr. Gray Herb. 184: 138 (1958); Delfini, C. in Zuloaga, F.O. & Belgrano, M.J. (eds), Fl. Argentina 17: 10 (2017).
 Notes. This variety was included by Foster in his checklist of Bolivian Begonia (Foster, 1958) but is endemic to Argentina (Tebbitt et al., 2018a). Foster cited no specimens, so we cannot confirm to which taxon Foster misapplied this name.
 Begonia micranthera var. foliosa L.B.Sm. & B.G.Schub., Darwiniana 5: 92 (1941b).
R.C. Foster, Contr. Gray Herb. 184: 138 (1958).
 Notes. This variety was described from Argentina by Smith & Schubert (1941b). A citation in their treatment of the begonias of Bolivia (Smith & Schubert, 1944a) showed that they still considered it as endemic to Argentina, but Foster (1958) probably misinterpreted this citation and included the variety in his Bolivian checklist. Tebbitt (2020) shows that this variety is endemic to Argentina and is a hybrid between Begonia micranthera Griseb. subsp. micranthera and B. micranthera subsp. rhacophylla (Irmsch.) Tebbitt
description: Published as part of Moonlight, Peter & Fuentes, Alfredo F., 2022, AN UPDATED CHECKLIST AND KEY TO THE SPECIES OF BOLIVIAN BEGONIA, INCLUDING ONE NEW SPECIES, pp. 1-66 in Edinburgh Journal of Botany 79 (407) on page 55, DOI: 10.24823/EJB.2022.407, http://zenodo.org/record/10553332
Index to Minutes of Meetings of the Executive Committee & the Board of Trustees, 1911-1946, "Car"
Creators: name: Carnegie Corporation Of New York
Publisher: name: Columbia University
Year: 2018
Subjects: Corporate meetings
Charitable uses, trusts, and foundations

description: The following microfilm is a copy of 5 x 8 Kardex cards hitherto used in the Cumulative Index to the Minutes of the Executive Committee and of the Board of Trustees of the Carnegie Corporation of New York, from the first meeting of the Trustees (November 10, 1911) through the 22nd meeting of the Executive Committee (September 17, 1946). The Cumulative Index was initiated during the early days of the Corporation when the offices of the President, the Secretary, and the Treasurer were separately organized, each with its own system of records. It was maintained by Durand R. Miller, first as secretary to the Secretary of the Corporation, James Bertram, and later as Record Clerk of the Corporation. The entries in the Cumulative Index are duplications of those recorded in the index of each bound volume of Minutes.
Existence and uniqueness of solutions for a boundary value problem arising from granular matter theory
Creators: name: Crasta, Graziano
name: Malusa, Annalisa
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35A02, 35J25

description: We consider a system of PDEs of Monge-Kantorovich type that, in the isotropic case, describes the stationary configurations of two-layers models in granular matter theory with a general source and a general boundary data. We propose a new weak formulation which is consistent with the physical model and permits us to prove existence and uniqueness results.
description: 25 pages, 3 figures
Prosopographia Burgundica
Creators: name: Blockmans, Wim
name: Boone, Marc
name: Paravicini, Werner
name: Prevenier, Walter
name: Rydder-Symoens, Hilde De
Publisher: name: Francia
Year: 2019

description: -
description: Francia, Bd. 24 Nr. 1 (1997)
Anthropocene under dark skies: The compounding effects of nuclear winter and overstepped planetary boundaries
Creators: name: Jehn, Florian Ulrich
Publisher: name: Zenodo
Year: 2023
Subjects: Nuclear Winter
Planetary Boundaries
Existential Risk

description: The analysis of global catastrophic events often occurs in isolation, simplifying their study. In reality, risks cascade and interact. This is a fact that is all too familiar due to COVID-19. Therefore, it is essential to consider how global risks interact. This investigation explores the interplay between nuclear winter and planetary boundaries. It may seem reasonable to assume that respecting planetary boundaries, which ensure a safe planetary operating space, before a nuclear war is always preferable. However, that does not always seem to be the case. For instance, increasing nitrogen emissions presently could act as a nutrient buffer during nuclear winter. Contrastingly, mitigating climate change, means an even larger temperature drop in nuclear winter in comparison with pre-industrial times. Nevertheless, this explorative study also highlights planetary boundaries whose preservation contributes to human survival, both now and after nuclear war. The best example being biosphere integrity, as conserving it has no direct downsides and will make the Earth system more resilient to resist the shock of a nuclear winter.
Bibliothèque nationale de France. Département des manuscrits. Centre de recherche sur les manuscrits enluminés. Manuscrits enluminés d'origine germanique. Tome I: Xe–XIVe siècles, par François Avril et Claudia Rabel, 1995
Creators: name: Bierbrauer, Katharina
Publisher: name: Francia
Year: 2019

description: -
description: Francia, Bd. 24 Nr. 1 (1997)
Path Integral Formulation for Lévy Flights - Evaluation of the Propagator for Free, Linear and Harmonic Potentials in the Over- and Underdamped Limits
Creators: name: Janakiraman, Deepika
name: Sebastian, K. L.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Lévy flights can be described using a Fokker-Planck equation which involves a fractional derivative operator in the position co-ordinate. Such an operator has its natural expression in the Fourier domain. Starting with this, we show that the solution of the equation can be written as a Hamiltonian path integral. Though this has been realized in the literature, the method has not found applications as the path integral appears difficult to evaluate. We show that a method in which one integrates over the position co-ordinates first, after which integration is performed over the momentum co-ordinates, can be used to evaluate several path integrals that are of interest. Using this, we evaluate the propagators for (a) free particle (b) particle subjected to a linear potential and (c) harmonic potential. In all the three cases, we have obtained results for both overdamped and underdamped cases.
description: 21 pages, 5 figures
A power-law distribution of phase-locking intervals does not imply critical interaction
Creators: name: Botcharova, Maria
name: Farmer, Simon F.
name: Berthouze, Luc
Publisher: name: arXiv
Year: 2012
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Neural synchronisation plays a critical role in information processing, storage and transmission. Characterising the pattern of synchronisation is therefore of great interest. It has recently been suggested that the brain displays broadband criticality based on two measures of synchronisation - phase locking intervals and global lability of synchronisation - showing power law statistics at the critical threshold in a classical model of synchronisation. In this paper, we provide evidence that, within the limits of the model selection approach used to ascertain the presence of power law statistics, the pooling of pairwise phase-locking intervals from a non-critically interacting system can produce a distribution that is similarly assessed as being power law. In contrast, the global lability of synchronisation measure is shown to better discriminate critical from non critical interaction.
description: (v3) Fixed error in Figure 1; (v2) Added references. Minor edits throughout. Clarified relationship between theoretical critical coupling for infinite size system and 'effective' critical coupling system for finite size system. Improved presentation and discussion of results; results unchanged. Revised Figure 1 to include error bars on r and N; results unchanged; (v1) 11 pages, 7 figures
Index to Minutes of Meetings of the Executive Committee & the Board of Trustees, 1911-1946, "Ch"
Creators: name: Carnegie Corporation Of New York
Publisher: name: Columbia University
Year: 2018
Subjects: Corporate meetings
Charitable uses, trusts, and foundations

description: The following microfilm is a copy of 5 x 8 Kardex cards hitherto used in the Cumulative Index to the Minutes of the Executive Committee and of the Board of Trustees of the Carnegie Corporation of New York, from the first meeting of the Trustees (November 10, 1911) through the 22nd meeting of the Executive Committee (September 17, 1946). The Cumulative Index was initiated during the early days of the Corporation when the offices of the President, the Secretary, and the Treasurer were separately organized, each with its own system of records. It was maintained by Durand R. Miller, first as secretary to the Secretary of the Corporation, James Bertram, and later as Record Clerk of the Corporation. The entries in the Cumulative Index are duplications of those recorded in the index of each bound volume of Minutes.
title: Mentoring Plan Template
Creators: name: Misra, Joya
Publisher: name: University of Massachusetts Amherst
Year: 2019

description: Mentoring plans allow departments to articulate how new faculty members will receive the mentoring and support that they need to be successful. While mentoring may happen “organically” for some faculty members, research shows that there are significant differences among faculty members in how much support and mentoring they receive, and even in how much honest feedback they receive.
Measuring the Mass Distribution in Galaxy Clusters
Creators: name: Geller, Margaret J.
name: Diaferio, Antonaldo
name: Serra, Kenneth J. Rines. Ana Laura
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Cluster mass profiles are tests of models of structure formation. Only two current observational methods of determining the mass profile, gravitational lensing and the caustic technique, are independent of the assumption of dynamical equilibrium. Both techniques enable determination of the extended mass profile at radii beyond the virial radius. For 19 clusters, we compare the mass profile based on the caustic technique with weak lensing measurements taken from the literature. This comparison offers a test of systematic issues in both techniques. Around the virial radius, the two methods of mass estimation agree to within about 30%, consistent with the expected errors in the individual techniques. At small radii, the caustic technique overestimates the mass as expected from numerical simulations. The ratio between the lensing profile and the caustic mass profile at these radii suggests that the weak lensing profiles are a good representation of the true mass profile. At radii larger than the virial radius, the lensing mass profile exceeds the caustic mass profile possibly as a result of contamination of the lensing profile by large-scale structures within the lensing kernel. We highlight the case of the closely neighboring clusters MS0906+11 and A750 to illustrate the potential seriousness of contamination of the the weak lensing signal by unrelated structures.
description: 35 pages, 13 figures, 2 tables, submitted to ApJ
Fast Estimation of Gravitational and Primordial Bispectra in Large Scale Structures
Creators: name: Schmittfull, M. M.
name: Regan, D. M.
name: Shellard, E. P. S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the implementation of a fast estimator for the full dark matter bispectrum of a three-dimensional particle distribution relying on a separable modal expansion of the bispectrum. The computational cost of accurate bispectrum estimation is negligible relative to simulation evolution, so the isotropic bispectrum can be used as a standard diagnostic whenever the power spectrum is evaluated. As an application we measure the evolution of gravitational and primordial dark matter bispectra in $N$-body simulations with Gaussian and non-Gaussian initial conditions of the local, equilateral, orthogonal and flattened shape. The results are compared to theoretical models using a 3D visualisation, 3D shape correlations and the cumulative bispectrum signal-to-noise, all of which can be evaluated extremely quickly. Our measured bispectra are determined by $\mathcal{O}(50)$ coefficients, which can be used as fitting formulae in the nonlinear regime and for non-Gaussian initial conditions. In the nonlinear regime with $k<2h\,\mathrm{Mpc}^{-1}$, we find an excellent correlation between the measured dark matter bispectrum and a simple model based on a `constant' bispectrum plus a (nonlinear) tree-level gravitational bispectrum. In the same range for non-Gaussian simulations, we find an excellent correlation between the measured additional bispectrum and a constant model plus a (nonlinear) tree-level primordial bispectrum. We demonstrate that the constant contribution to the non-Gaussian bispectrum can be understood as a time-shift of the constant mode in the gravitational bispectrum, which is motivated by the one-halo model. The final amplitude of this extra non-Gaussian constant contribution is directly related to the initial amplitude of the constant mode in the primordial bispectrum. We also comment on the effects of regular grid and glass initial conditions on the bispectrum.
description: 34 pages, 21 figures
The HAVEN study-hydroxychloroquine in ANCA vasculitis evaluation-a multicentre, randomised, double-blind, placebo-controlled trial: study protocol and statistical analysis plan.
Creators: name: Learoyd, Annastazia E
name: Arnold, Lauren
name: Reid, Fiona
name: Beckley-Hoelscher, Nicholas
name: Casian, Alina
name: Sangle, Shirish
name: Morton, Neil
name: Nel, Louise
name: Cape, Angela
name: John, Susan
name: Kim, Sangmi
name: Shivapatham, Dharshene
name: Luqmani, Raashid
name: Jayne, David
name: Galloway, James
name: Douiri, Abdel
name: D'Cruz, David
name: HAVEN Study Group
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: AAV
ANCA
Auto-immune conditions
Hydroxychloroquine
Prednisolone
Vasculitis

description: BACKGROUND: Patients with non-severe ANCA-associated vasculitis (AAV) are often prescribed immunosuppressive medications that are associated with severe side effects and a reduced quality of life. There is an unmet need for safer effective treatments for these patients. Hydroxychloroquine is being explored due to its effect in similar autoimmune conditions such as systemic lupus erythematosus. METHODS: Double-blind, placebo-controlled multicentre trial recruiting 76 patients across 20 sites. Participants will be randomised 1:1 to hydroxychloroquine or placebo in addition to standard of care immunosuppressive therapies over the course of 52 weeks. A phase II selection design will be used to determine hdroxychloroquine's efficacy, using prednisolone dosage and Birmingham Vasculitis Activity Score as a measure of disease activity. Secondary outcomes will explore other elements of AAV progression, including disease flares and time to remission. DISCUSSION: This trial aims to explore Hydroxychloroquine as a treatment for patients with AAV. If effective, the need for immunosuppressive treatments such as prednisolone could be reduced. Hydroxychloroquine is safer, cheaper and has fewer adverse effects than conventional immunosuppressive treatments. This could improve patient outcomes while saving money for the NHS. TRIAL REGISTRATION: ISRCTN: ISRCTN79334891. Registered 07 June 2021. EudraCT: 2018-001268-40. Registered 13 September 2019. CLINICALTRIALS: gov: NCT04316494. Registered 20 March 2020.
A deep hierarchy of predictions enables online meaning extraction in a computational model of human speech comprehension.
Creators: name: Su, Yaqing
name: MacGregor, Lucy J
name: Olasagasti, Itsaso
name: Giraud, Anne-Lise
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: Humans
Comprehension
Speech
Speech Perception
Brain
Language

description: Acknowledgements: We thank B. Bickel, S. van Ommen, D. Poeppel for critical feedback, NCCR TTF Data Science for support on the GPT-2 model, and E. Holmes for advice on the SPM software.
description: Understanding speech requires mapping fleeting and often ambiguous soundwaves to meaning. While humans are known to exploit their capacity to contextualize to facilitate this process, how internal knowledge is deployed online remains an open question. Here, we present a model that extracts multiple levels of information from continuous speech online. The model applies linguistic and nonlinguistic knowledge to speech processing, by periodically generating top-down predictions and incorporating bottom-up incoming evidence in a nested temporal hierarchy. We show that a nonlinguistic context level provides semantic predictions informed by sensory inputs, which are crucial for disambiguating among multiple meanings of the same word. The explicit knowledge hierarchy of the model enables a more holistic account of the neurophysiological responses to speech compared to using lexical predictions generated by a neural network language model (GPT-2). We also show that hierarchical predictions reduce peripheral processing via minimizing uncertainty and prediction error. With this proof-of-concept model, we demonstrate that the deployment of hierarchical predictions is a possible strategy for the brain to dynamically utilize structured knowledge and make sense of the speech input.
High-throughput metabolomics for the design and validation of a diauxic shift model.
Creators: name: Brunnsåker, Daniel
name: Reder, Gabriel K
name: Soni, Nikul K
name: Savolainen, Otto I
name: Gower, Alexander H
name: Tiukova, Ievgeniia A
name: King, Ross D
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Metabolomics

description: Acknowledgements: This work was partially supported by the Wallenberg AI, Autonomous Systems and Software Program (WASP) funded by the Knut and Alice Wallenberg Foundation, and the Swedish Research Council Formas (2020-01690).
description: Funder: The Wallenberg AI, Autonomous Systems and Software Program (WASP)
description: Saccharomyces cerevisiae is a very well studied organism, yet ∼20% of its proteins remain poorly characterized. Moreover, recent studies seem to indicate that the pace of functional discovery is slow. Previous work has implied that the most probable path forward is via not only automation but fully autonomous systems in which active learning is applied to guide high-throughput experimentation. Development of tools and methods for these types of systems is of paramount importance. In this study we use constrained dynamical flux balance analysis (dFBA) to select ten regulatory deletant strains that are likely to have previously unexplored connections to the diauxic shift. We then analyzed these deletant strains using untargeted metabolomics, generating profiles which were then subsequently investigated to better understand the consequences of the gene deletions in the metabolic reconfiguration of the diauxic shift. We show that metabolic profiles can be utilised to not only gaining insight into cellular transformations such as the diauxic shift, but also on regulatory roles and biological consequences of regulatory gene deletion. We also conclude that untargeted metabolomics is a useful tool for guidance in high-throughput model improvement, and is a fast, sensitive and informative approach appropriate for future large-scale functional analyses of genes. Moreover, it is well-suited for automated approaches due to relative simplicity of processing and the potential to make massively high-throughput.
Pierre Desportes, Hélène Millet (Hrsg.), Fasti Ecclesiae Gallicanae. Répertoire prosopographique des évêques, dignitaires et chanoines de France de 1200 à 1500. T. I: Diocèse d'Amiens 1996
Creators: name: Müller, Heribert
Publisher: name: Francia
Year: 2019

description: -
description: Francia, Bd. 24 Nr. 1 (1997)
Towards Automated Refactoring of Smelly Test Code
Creators: name: Santana, Railana
Publisher: name: Zenodo
Year: 2023
Subjects: Software testing
Refactoring
Test smells

description: Test Refactoring improves the internal aspects of the software test without modifying its external behavior. However, the test code quality, i.e., design and writing standards, is not commonly prioritized within the industry. Test smells are anti-patterns that can harm the software testing understanding and maintenance. Although academia has constantly explored issues related to test smells and test code quality, there are still opportunities to improve how developers handle test code refactoring. This study initially provides a systematic mapping of the literature, which analyzed 42 primary works about test refactoring. The majority of the studies presented generic refactorings suitable for both production and test code. Some anti-patterns had multiple refactoring strategies, while others lacked a clear strategy. Existing tools have not evolved significantly since their inception, and many refactoring strategies have yet to be evaluated. Also, we investigated the effect of refactoring on the co-occurrence of test smells and observed that restructuring the test code can relocate or remove multiple test smell instances together. In this context, this study seeks to contribute with guidelines for refactoring multiple test smells, providing the order in which the refactoring should be applied to reduce the changes in test code. Furthermore, we intend to automate these guidelines and evaluate them with practitioners.
The evolution of cooperation by social exclusion
Creators: name: Sasaki, Tatsuya
name: Uchida, Satoshi
Publisher: name: arXiv
Year: 2012
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: The exclusion of freeriders from common privileges or public acceptance is widely found in the real world. Current models on the evolution of cooperation with incentives mostly assume peer sanctioning, whereby a punisher imposes penalties on freeriders at a cost to itself. It is well known that such costly punishment has two substantial difficulties. First, a rare punishing cooperator barely subverts the asocial society of freeriders, and second, natural selection often eliminates punishing cooperators in the presence of non-punishing cooperators (namely, "second-order" freeriders). We present a game-theoretical model of social exclusion in which a punishing cooperator can exclude freeriders from benefit sharing. We show that such social exclusion can overcome the above-mentioned difficulties even if it is costly and stochastic. The results do not require a genetic relationship, repeated interaction, reputation, or group selection. Instead, only a limited number of freeriders are required to prevent the second-order freeriders from eroding the social immune system.
description: 28 pages, 3 figures, supplementary material (materials and methods, and 6 supplementary figures)
title: Coarse-grained model of a nanoscale-segregated ionic liquid for simulations of low-temperature structure and dynamics
Creators: name: Kloth, Sebastian
name: Bernhardt, Marvin P.
name: Vegt, Nico F. A. van der
name: Vogel, Michael
Publisher: name: IOP Publishing
Year: 2021

description: We perform molecular dynamics simulations to study the structure and dynamics of the ionic liquid [Omim][TFSI] in a broad temperature range. A particular focus is the progressing nanoscale segregation into polar and nonpolar regions upon cooling. As this analysis requires simulations of large systems for long times, we use the iterative Boltzmann inversion method to develop a new coarse-grained (CG) model from a successful all-atom (AA) model.We show that the properties are similar for both levels of description at room temperature, while the CG model shows stronger nanoscale segregation and faster diffusion dynamics than its AA counterpart at low temperatures. Exploiting these features of the CG model, we find that the characteristic length scale of the structural inhomogeneity nearly doubles to ∼3 nm when the temperature is decreased to about 200 K. Moreover, we observe that the nanoscale segregation is characterized by a bicontinuous morphology. In worm-like nonpolar regions, the ends of the octyl rests of the cations preferentially aggregate in the centers, while the other parts of the alkyl chains tend to be aligned parallel on a next-neighbor level and point outward, allowing for an integration of the imidazolium head groups of the cations into polar regions together with the anions, resembling to some degree the molecular arrangement in cylindrical micelles.
Is information provided within chronic subdural haematoma education resources adequate? A scoping review.
Creators: name: Gillespie, Conor S
name: Khanna, Samuel
name: Vivian, Mark E
name: McKoy, Samuel
name: Yanez Touzet, Alvaro
name: Edlmann, Ellie
name: Stubbs, Daniel J
name: Davies, Benjamin M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: Humans
Aged
Hematoma, Subdural, Chronic
Educational Status
Decision Making, Shared

description: Acknowledgements: We would like to thank Dr Ali Alam, for providing feedback on the structure of the manuscript prior to submission.
description: BACKGROUND: Chronic subdural haematoma (CSDH) is becoming increasingly prevalent, due to an aging population with increasing risk factors. Due to its variable disease course and high morbidity, patient centred care and shared decision making are essential. However, its occurrence in frail populations, remote from specialist neurosurgeons who currently triage treatment decisions, challenges this. Education is an important component of enabling shared decisions. This should be targeted to avoid information overload. However, it is unknown what this should be. OBJECTIVES: Our objectives were to conduct analysis of the content of existing CSDH educational materials, to inform the development of patient and relative educational resources to facilitate shared decision making. METHODS: A literature search was conducted (July 2021) of MEDLINE, Embase and grey literature, for all self-specified resources on CSDH education, and narrative reviews. Resources were classified into a hierarchical framework using inductive thematic analysis into 8 core domains: Aetiology, epidemiology and pathophysiology; natural history and risk factors; symptoms; diagnosis; surgical management; nonsurgical management; complications and recurrence; and outcomes. Domain provision was summarised using descriptive statistics and Chi-squared tests. RESULTS: 56 information resources were identified. 30 (54%) were resources designed for healthcare professionals (HCPs), and 26 (46%) were patient-orientated resources. 45 (80%) were specific to CSDH, 11 (20%) covered head injury, and 10 (18%) referenced both acute and chronic SDH. Of 8 core domains, the most reported were aetiology, epidemiology and pathophysiology (80%, n = 45) and surgical management (77%, n = 43). Patient orientated resources were more likely to provide information on symptoms (73% vs 13%, p<0.001); and diagnosis (62% vs 10%, p<0.001) when compared to HCP resources. Healthcare professional orientated resources were more likely to provide information on nonsurgical management (63% vs 35%, p = 0.032), and complications/recurrence (83% vs 42%, p = 0.001). CONCLUSION: The content of educational resources is varied, even amongst those intended for the same audience. These discrepancies indicate an uncertain educational need, that will need to be resolved in order to better support effective shared decision making. The taxonomy created can inform future qualitative studies.
Christiane Raabe, Das Zisterzienserkloster Mariental bei Helmstedt von der Gründung 1138–1337. Die Besitz- und Wirtschaftsgeschichte unter Einbeziehung der politischen und ordensgeschichtlichen Stellung, 1995
Creators: name: Lohrmann, Dietrich
Publisher: name: Francia
Year: 2019

description: -
description: Francia, Bd. 24 Nr. 1 (1997)
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
Creators: name: Agam, Ganesh
name: Gebhardt, Christian
name: Popara, Milana
name: Mächtel, Rebecca
name: Folz, Julian
name: Ambrose, Benjamin
name: Chamachi, Neharika
name: Chung, Sang Yoon
name: Craggs, Timothy D
name: De Boer, Marijn
name: Grohmann, Dina
name: Ha, Taekjip
name: Hartmann, Andreas
name: Hendrix, Jelle
name: Hirschfeld, Verena
name: Hübner, Christian G
name: Hugel, Thorsten
name: Kammerer, Dominik
name: Kang, Hyun-Seo
name: Kapanidis, Achillefs N
name: Krainer, Georg
name: Kramm, Kevin
name: Lemke, Edward A
name: Lerner, Eitan
name: Margeat, Emmanuel
name: Martens, Kirsten
name: Michaelis, Jens
name: Mitra, Jaba
name: Moya Muñoz, Gabriel G
name: Quast, Robert B
name: Robb, Nicole C
name: Sattler, Michael
name: Schlierf, Michael
name: Schneider, Jonathan
name: Schröder, Tim
name: Sefer, Anna
name: Tan, Piau Siong
name: Thurn, Johann
name: Tinnefeld, Philip
name: Van Noort, John
name: Weiss, Shimon
name: Wendler, Nicolas
name: Zijlstra, Niels
name: Barth, Anders
name: Seidel, Claus AM
name: Lamb, Don C
name: Cordes, Thorben
Publisher: name: Apollo - University of Cambridge Repository
Year: 2023
Subjects: Fluorescence Resonance Energy Transfer
Reproducibility of Results
Proteins
Molecular Conformation
Laboratories

description: Funder: Ludwig Maximilians University Munich | Center for NanoScience, Ludwig-Maximilians-Universität Mnchen (CeNS, LMU); doi: https://doi.org/10.13039/501100007153
description: Funder: Alexander von Humboldt-Stiftung (Alexander von Humboldt Foundation); doi: https://doi.org/10.13039/100005156
description: Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study of biomolecular structure and dynamics in vitro and in vivo. We performed an international blind study involving 19 laboratories to assess the uncertainty of FRET experiments for proteins with respect to the measured FRET efficiency histograms, determination of distances, and the detection and quantification of structural dynamics. Using two protein systems with distinct conformational changes and dynamics, we obtained an uncertainty of the FRET efficiency ≤0.06, corresponding to an interdye distance precision of ≤2 Å and accuracy of ≤5 Å. We further discuss the limits for detecting fluctuations in this distance range and how to identify dye perturbations. Our work demonstrates the ability of smFRET experiments to simultaneously measure distances and avoid the averaging of conformational dynamics for realistic protein systems, highlighting its importance in the expanding toolbox of integrative structural biology.
Duality Invariant M-theory: Gauged supergravities and Scherk-Schwarz reductions
Creators: name: Berman, David S.
name: Musaev, Edvard T.
name: Thompson, Daniel C.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the reduction of the duality invariant approach to M-theory by a U-duality group valued Scherk-Schwarz twist. The result is to produce potentials for gauged supergravities that are normally associated with non-geometric compactifications. The local symmetry reduces to gauge transformations with the gaugings exactly matching those of the embedding tensor approach to gauged supergravity. Importantly, this approach now includes a nontrivial dependence of the fields on the extra coordinates of the extended space.
description: 22 pages Latex; v2: typos corrected and references added
Fréderique Donnay (Hrsg.), Inventaire analytique de documents relatifs à l'histoire du diocèse de Liège sous le régime des nonces de Cologne: Giuseppe-Maria Sanfelice (1652–1659), 1991
Creators: name: Babel, Rainer
Publisher: name: Francia
Year: 2019

description: -
description: Francia, Bd. 24 Nr. 2 (1997)