Additional file 1 of Accelerometer-measured physical activity, frailty, and all-cause mortality and life expectancy among middle-aged and older adults: a UK Biobank longitudinal study
Creators: name: Yang, Yang
name: Chen, Liangkai
name: Filippidis, Filippos T.
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1. Fig. S1. Flowchart of participant enrolment. Fig. S2. Correlation between accelerometer-measured PA and ST. Fig. S3. Timeline of some covariates collection. Fig. S4. The estimates of cumulative survival time from 50 years of age onward among women and men among different levels of frailty index. Fig. S5. The estimates of cumulative survival time from 50 years of age onward among women and men among different levels of accelerometer-measured PA and ST. Fig. S6. Joint associations of accelerometer-measured TVPA, MVPA, LPA and ST with all-cause mortality (awake time: 07:00–21:00). Fig. S7. Dose–response associations (HR and 95%CI) between accelerometer-measured TVPA, MVPA, LPA, ST with all-cause mortality by frailty index categories using restricted cubic splines with four knots located at the 5th, 35th, 65th, 95th percentiles of each exposure (awake time: 07:00–21:00). Fig. S8. Joint associations of accelerometer-measured TVPA, MVPA, LPA and ST with all-cause mortality (awake time: 08:00–20:00). Fig. S9. Dose–response associations (HR and 95%CI) between accelerometer-measured TVPA, MVPA, LPA, ST with all-cause mortality by frailty index categories using restricted cubic splines with four knots located at the 5th, 35th, 65th, and 95th percentiles of each exposure (awake time: 08:00–20:00). Table S1. Comparison of baseline characteristics of participants with and without complete frailty index data. Table S2. Items used for constructing frailty index. Table S3. The resource and definition of the covariates. Table S4. Definition of each component of a healthy diet score. Table S5. The numbers (percentages) of participants with missing covariates. Table S6. Baseline characteristics of the participants stratified by frailty index (before imputation). Table S7. Baseline characteristics of the participants stratified by TVPA. Table S8. Baseline characteristics of the participants stratified by MVPA. Table S9. Baseline characteristics of the participants stratified by LPA. Table S10. Baseline characteristics of the participants stratified by ST. Table S11. Joint associations of accelerometer-measured TVPA, MVPA, LPA, and ST with frailty status on all-cause mortality. Table S12. Joint associations of accelerometer-measured TVPA, MVPA, LPA, and ST with frailty status on all-cause mortality (remove deaths within first 2 years, n = 78,062). Table S13. Joint associations of accelerometer-measured TVPA, MVPA, LPA, and ST with frailty status on all-cause mortality (remove missing values, n = 64,771). Table S14. Joint associations of accelerometer-measured TVPA, MVPA, LPA, and ST with frailty status on all-cause mortality (remove night shift workers, n = 75,571). Table S15. Joint associations of accelerometer-measured TVPA, MVPA, LPA, and ST with frailty status on all-cause mortality (awake time: 07:00–21:00). Table S16. Joint associations of accelerometer-measured TVPA, MVPA, LPA, and ST with frailty status on all-cause mortality (awake time: 08:00–20:00). Table S17. Joint associations of accelerometer-measured MVPA and LPA with frailty status on all-cause mortality (further mutually adjusted for MVPA or LPA). Table S18. Analyses on interaction of accelerometer-measured physical activity and sedentary and pre-frailty with all-cause mortality. Table S19. Analyses on interaction of accelerometer-measured physical activity and sedentary and frailty with all-cause mortality. Table S20. Association between frailty index and all-cause mortality. Table S21. Association between accelerometer-measured TVPA, MVPA, LPA, and ST and all-cause mortality. Table S22. Association between various covariates and frailty index using logistic regression models (reference group: robust). Table S23. Association between various covariates and all-cause mortality using cox regression models. Supplementary Method. Estimating the differences in life expectancy.