cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Trajectory planning for quadcopter control system using visual processing
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
title: ÐÐ»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÐ°ÐµÐºÑÐ¾ÑÐ¸Ð¸ Ð´Ð»Ñ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÐºÐ²Ð°Ð´ÑÐ¾ÐºÐ¾Ð¿ÑÐµÑÐ¾Ð¼ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð²Ð¸Ð·ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸
Creators: name: ÐÐ¾Ñ Ð°Ð¼Ð°Ð´ ÐÐµÑ Ð´Ð¸ ÐÑÐ¸Ðµ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÐ²Ð°Ð´ÑÐ¾ÐºÐ¾Ð¿ÑÐµÑÑ
Ð Ð°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²
Ð²Ð¸Ð·ÑÐ°Ð»ÑÐ½Ð°Ñ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ°

description: This paper describes a solution we devised in order to solve a common real life problem where in general, drivers and operators of big and heavy machinery often get into work and traffic accidents due to lack of enough view of the environment around them. For this, we will be developing a system that consist of a quadcopter hovering above and following the said vehicle when needed and provide visual support and aid to the operator through a control station and data display screen in the vehicle itself. This will be achieved through implementing various techniques in computer vision regarding object detection, analysis, and identification, and object tracking algorithms where the system should understand different cars and objects preprogrammed as training data.
description: Ð ÑÑÐ¾Ð¼ Ð´Ð¾ÐºÑÐ¼ÐµÐ½ÑÐµ Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÐµÑÑÑ ÑÐµÑÐµÐ½Ð¸Ðµ, ÐºÐ¾ÑÐ¾ÑÐ¾Ðµ Ð¼Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð»Ð¸ Ð´Ð»Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð¾Ð±ÑÐµÐ¹ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ ÑÐµÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¶Ð¸Ð·Ð½Ð¸, ÐºÐ¾Ð³Ð´Ð° Ð² ÑÐµÐ»Ð¾Ð¼ Ð²Ð¾Ð´Ð¸ÑÐµÐ»Ð¸ Ð¸ Ð¾Ð¿ÐµÑÐ°ÑÐ¾ÑÑ Ð±Ð¾Ð»ÑÑÐ¾Ð¹ Ð¸ ÑÑÐ¶ÐµÐ»Ð¾Ð¹ ÑÐµÑÐ½Ð¸ÐºÐ¸ ÑÐ°ÑÑÐ¾ Ð¿Ð¾Ð¿Ð°Ð´Ð°ÑÑ Ð² ÑÐ°Ð±Ð¾ÑÑ Ð¸ Ð´Ð¾ÑÐ¾Ð¶Ð½Ð¾-ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ½ÑÐµ Ð¿ÑÐ¾Ð¸ÑÑÐµÑÑÐ²Ð¸Ñ Ð¸Ð·-Ð·Ð° Ð¾ÑÑÑÑÑÑÐ²Ð¸Ñ Ð´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¾Ð± Ð¾ÐºÑÑÐ¶Ð°ÑÑÐµÐ¹ ÑÑÐµÐ´Ðµ Ð²Ð¾ÐºÑÑÐ³ Ð½Ð¸Ñ. ÐÐ»Ñ ÑÑÐ¾Ð³Ð¾ Ð¼Ñ Ð±ÑÐ´ÐµÐ¼ ÑÐ°Ð·ÑÐ°Ð±Ð°ÑÑÐ²Ð°ÑÑ ÑÐ¸ÑÑÐµÐ¼Ñ, ÑÐ¾ÑÑÐ¾ÑÑÑÑ Ð¸Ð· ÐºÐ²Ð°Ð´ÑÐ¾ÑÐ¸ÐºÐ»Ð°, Ð²Ð¸ÑÑÑÐµÐ³Ð¾ Ð²ÑÑÐµ Ð¸ Ð¿Ð¾ÑÐ»Ðµ ÑÐºÐ°Ð·Ð°Ð½Ð½Ð¾Ð³Ð¾ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ½Ð¾Ð³Ð¾ ÑÑÐµÐ´ÑÑÐ²Ð°, ÐºÐ¾Ð³Ð´Ð° ÑÑÐ¾ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾, Ð¸ Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑÐµÐ³Ð¾ Ð²Ð¸Ð·ÑÐ°Ð»ÑÐ½ÑÑ Ð¿Ð¾Ð´Ð´ÐµÑÐ¶ÐºÑ Ð¸ Ð¿Ð¾Ð¼Ð¾ÑÑ Ð¾Ð¿ÐµÑÐ°ÑÐ¾ÑÑ ÑÐµÑÐµÐ· Ð¿Ð°Ð½ÐµÐ»Ñ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¸ ÑÐºÑÐ°Ð½ Ð¾ÑÐ¾Ð±ÑÐ°Ð¶ÐµÐ½Ð¸Ñ Ð´Ð°Ð½Ð½ÑÑ Ð² ÑÐ°Ð¼Ð¾Ð¼ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐ½Ð¾Ð¼ ÑÑÐµÐ´ÑÑÐ²Ðµ. Ð­ÑÐ¾ Ð±ÑÐ´ÐµÑ Ð´Ð¾ÑÑÐ¸Ð³Ð½ÑÑÐ¾ Ð·Ð° ÑÑÐµÑ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÐºÐ¾Ð¼Ð¿ÑÑÑÐµÑÐ½Ð¾Ð³Ð¾ Ð·ÑÐµÐ½Ð¸Ñ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¸Ñ, Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð¸Ð´ÐµÐ½ÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ Ð¾Ð±ÑÐµÐºÑÐ¾Ð², Ð° ÑÐ°ÐºÐ¶Ðµ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð¾Ð² Ð¾ÑÑÐ»ÐµÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ð¾Ð±ÑÐµÐºÑÐ¾Ð², Ð³Ð´Ðµ ÑÐ¸ÑÑÐµÐ¼Ð° Ð´Ð¾Ð»Ð¶Ð½Ð° Ð¿Ð¾Ð½Ð¸Ð¼Ð°ÑÑ ÑÐ°Ð·Ð½ÑÐµ Ð°Ð²ÑÐ¾Ð¼Ð¾Ð±Ð¸Ð»Ð¸ Ð¸ Ð¾Ð±ÑÐµÐºÑÑ, Ð¿ÑÐµÐ´Ð²Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð·Ð°Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ ÐºÐ°Ðº Ð´Ð°Ð½Ð½ÑÐµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ.
Unblurring the Lines: The Language of International Protection
Creators: name: Usherwood, Simon
Publisher: name: Zenodo
Year: 2023
Subjects: refugee and migration policy
PROTECT Consortium

description: This policy brief focuses on the importance of clear and precise language in providing international protection. The author argues that the imprecise use of language, intentionally or unintentionally, compromises the protection of refugees in five ways. Firstly, rolling refugees into other categories such as migrants makes it more difficult to delineate effective legal rights and obligations. Secondly, political obfuscation over precise terms reinforces confused media and public debates in recipient states. Thirdly, the language of vulnerability has become instrumentalized to limit protection. Fourthly, civil society groups further complicate matters through their more-finely differentiated typologies. Finally, the arrival of the Global Compacts on Refugees and on Migration have opened up a new gap in language and the provision of protection. The author argues that all relevant participants in the provision of
 international protection must be mindful of the importance of clear and precise language around the description and definition of refugees, migrants, asylum seekers, immigration policy, and border security to avoid generating political and social tensions.
Entanglement Evolution in a Non-Markovian Environment
Creators: name: Yu, Ting
name: Eberly, J. H.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We extend recent theoretical studies of entanglement dynamics in the presence of environmental noise, following the long-time interest of Krzysztof Wodkiewicz in the effects of stochastic models of noise on quantum optical coherences. We investigate the quantum entanglement dynamics of two spins in the presence of classical Ornstein-Uhlenbeck noise, obtaining exact solutions for evolution dynamics. We consider how entanglement can be affected by non-Markovian noise, and discuss several limiting cases.
description: REVTeX, 6 pages, 4 figures. Submission for a Special Issue of Optics Communications in Memory of Krzystof Wodkiewicz
Comparative analysis of genomic characteristics, fitness and virulence of MRSA ST398 and ST9 isolated from China and Germany
Creators: name: Ji, Xing
name: Krüger, Henrike
name: Tao, Jin
name: Wang, Yaxin
name: Fessler, Andrea T.
name: Bai, Rina
name: Wang, Shaolin
name: Dong, Yanjun
name: Shen, Jianzhong
name: Schwarz, Stefan
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: MRSA
subject: genome
subject: fitness
subject: virulence
subject: pig
subject: ST398
subject: ST9
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Methicillin-resistant Staphylococcus aureus (MRSA) of sequence types ST398 and ST9 are dominant lineages among livestock in Europe and Asia, respectively. Although both STs were commonly found as colonizers of the skin and the mucosal membranes, MRSA ST398, rather than MRSA ST9, has been reported to cause infections in humans and animals. Herein, we comparatively analyzed the genomic characteristics, fitness and virulence of MRSA ST398 and ST9 isolated from pigs in both China (CHN) and Germany (GER) to explore the factors that lead to differences in their epidemics and pathogenicity. We observed that the CHN-MRSA ST9 and the GER-MRSA ST9 have evolved independently, whereas the CHN-MRSA ST398 and GER-MRSA ST398 had close evolutionary relationships. Resistance to antimicrobial agents commonly used in livestock, the enhanced ability of biofilm formation, and the resistance to desiccation contribute to the success of the dominant clones of CHN-MRSA ST9 and GER-MRSA ST398, and the vwbνSaα gene on the genomic island might in part contribute to their colonization fitness in pigs. All MRSA ST398 strains revealed more diverse genome structures, higher tolerance to acids and high osmotic pressure, and greater competitive fitness in co-culture experiments. Notably, we identified and characterized a novel hysAνSaβ gene, which was located on the genomic island νSaβ of MRSA ST398 but was absent in MRSA ST9. The enhanced pathogenicity of the MRSA ST398 strains due to hysAνSaβ might in part explain why MRSA ST398 strains are more likely to cause infections.
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð»Ð°ÑÐ¾Ð², ÐÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð°
Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸Ñ
Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ðµ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð°
ÑÐ¸ÑÑÐµÐ¼Ð° Ð¿ÑÐµÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
Ð¿ÑÐµÐ¼Ð¸Ñ

description: ÐÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ ÑÐµÐ¼Ñ ÑÐ¾ÑÑÐ¾Ð¸Ñ Ð² ÑÐ¾Ð¼, ÑÑÐ¾ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ñ ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð¿ÑÐ¸Ð±ÑÐ»ÑÐ½Ð¾ÑÑÑ Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð½ÐµÐ²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ Ð±ÐµÐ· ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð°, Ð¿Ð¾ÑÐºÐ¾Ð»ÑÐºÑ Ð¸Ð¼ÐµÐ½Ð½Ð¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð°Ñ ÑÑÑÐ´Ð¾Ð²Ð°Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ ÑÐ¾ÑÑÑÐ´Ð½Ð¸ÐºÐ¾Ð² Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ñ Ðº Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐ¼ ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¸Ð¼ ÑÐµÐ»ÑÐ¼ Ð±Ð¸Ð·Ð½ÐµÑÐ°. ÐÐ±ÑÐµÐºÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ - ÐÐÐ Â«Ð¡ÐÐÐÐ Ð¡Ð¢Ð ÐÐÂ». ÐÑÐµÐ´Ð¼ÐµÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ - ÑÐ¸ÑÑÐµÐ¼Ð° ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° ÐÐÐ Â«Ð¡ÐÐÐÐ Ð¡Ð¢Ð ÐÐÂ». Ð¦ÐµÐ»ÑÑ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ ÐÐÐ Â«Ð¡ÐÐÐÐ Ð¡Ð¢Ð ÐÐÂ»Â» Ð¸ ÐµÑ ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ðµ. ÐÑÐ¾Ð²ÐµÐ´ÑÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¸ÑÑÐµÐ¼Ñ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ ÐÐÐ Â«Ð¡ÐÐÐÐ Ð¡Ð¢Ð ÐÐÂ». Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð°. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð´Ð»Ñ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ.
Stochastic Matrix Product States
Creators: name: Temme, Kristan
name: Verstraete, Frank
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The concept of stochastic matrix product states is introduced and a natural form for the states is derived. This allows to define the analogue of Schmidt coefficients for steady states of non-equilibrium stochastic processes. We discuss a new measure for correlations which is analogous to the entanglement entropy, the entropy cost $S_C$, and show that this measure quantifies the bond dimension needed to represent a steady state as a matrix product state. We illustrate these concepts on the hand of the asymmetric exclusion process.
Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and tetralogy of fallot, and its functional evaluation in the Drosophila heart
Creators: name: Auxerre-Plantié, Emilie
name: Nielsen, Tanja
name: Grunert, Marcel
name: Olejniczak, Olga
name: Perrot, Andreas
name: Özcelik, Cemil
name: Harries, Dennis
name: Matinmehr, Faramarz
name: Dos Remedios, Cristobal
name: Mühlfeld, Christian
name: Kraft, Theresia
name: Bodmer, Rolf
name: Vogler, Georg
name: Sperling, Silke R.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Congenital heart disease
subject: Cardiomyopathy
subject: CG14964
subject: Myomesin
subject: Candidate gene
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known disease genes for the majority of cases. In this study, we identified mutations in myomesin 2 (MYOM2) in patients with Tetralogy of Fallot (TOF), the most common cyanotic heart malformation, as well as in patients with hypertrophic cardiomyopathy (HCM), who do not exhibit any mutations in the known disease genes. MYOM2 is a major component of the myofibrillar Moand of the sarcomere, and a hub gene within interactions of sarcomere genes. We show that patient-derived cardiomyocytes exhibit myofibrillar disarray and reduced passive force with increasing sarcomere lengths. Moreover, our comprehensive functional analyses in the Drosophila animal model reveal that the so far uncharacterized fly gene CG14964 [herein referred to as Drosophila myomesin and myosin binding protein (dMnM)] may be an ortholog of MYOM2, as well as other myosin binding proteins . Its partial loss of function or moderate cardiac knockdown results in cardiac dilation, whereas more severely reduced function causes a constricted phenotype and an increase in sarcomere myosin protein. Moreover, compound heterozygous combinations of CG14964 and the sarcomere gene Mhc (MYH6/7) exhibited synergistic genetic interactions. In summary, our results suggest that MYOM2 not only plays a critical role in maintaining robust heart function but may also be a candidate gene for heart diseases such as HCM and TOF, as it is clearly involved in the development of the heart.
Hypertension in pregnancy and its management
Creators: name: 1Dr Maryam Fatima,2Dr Fareeza Sattar,3Dr Sidra Yasin
Publisher: name: Zenodo
Year: 2019

description: Introduction
 The most common medical complications of pregnancy is hypertension and its disorder which are an important cause of maternal and perinatal morbidity and mortality worldwide.1 During normal gestation period systolic pressure changes slightly whereas diastolic pressure drops by 10 mm Hg early in 13 to 20 weeks and increases again to pre-pregnancy levels in the third trimester. [1]
 The term hypertension in pregnancy is actually a very broad term which has further conditions in which blood pressure varies accordingly. All current definitions and classification schemes have certain pitfalls as they relate to clinical diagnosis and management.
 Nevertheless, a recent report by the Working Group on High Blood Pressure in Pregnancy recommended using the classification system proposed by the American College of Obstetricians and Gynecologists even though this classification is not accepted in many countries outside the United States.2
 In this review, hypertensive disorders of pregnancy will be divided into three categories: chronic hypertension, gestational hypertension, and preeclampsia (Table 1).
 Chronic Hypertension
 The incidence of chronic hypertension in gestation women ranges from 1-5%. [3] The rates are higher in older women, obese women, and black women.8 It is difficult to diagnose chronic hypertension in pregnant women who never regularly monitored their blood pressure.
 In such cases, the diagnosis is usually based on the presence of hypertension before 20 weeks’ gestation. In some women, however, hypertension before 20 weeks’ gestation may be the first manifestation of preeclampsia. [4] Furthermore, because of the normal physiologic decrease in blood pressure during the 2nd trimester, majority of women with chronic hypertension have normal blood pressure before 20 weeks’ gestation. On the basis of either the systolic or the diastolic blood pressure non-pregnant women and in men, hypertension is often classified as mild, moderate, severe, or very severe. Whereas pregnant women suffering from chronic hypertension are considered either mild or severe. However there is no agreed statement on definition of mild hypertension, there is agreement that a diastolic blood pressure of 110 mm Hg or higher (Korotkoff phase
Effects of Daytime Dry Fasting on Hydration, Glucose Metabolism and Circadian Phase: A Prospective Exploratory Cohort Study in Bahá'í Volunteers
Creators: name: Koppold-Liebscher, Daniela A.
name: Klatte, Caroline
name: Demmrich, Sarah
name: Schwarz, Julia
name: Kandil, Farid I.
name: Steckhan, Nico
name: Ring, Raphaela
name: Kessler, Christian S.
name: Jeitler, Michael
name: Koller, Barbara
name: Ananthasubramaniam, Bharath
name: Eisenmann, Clemens
name: Mähler, Anja
name: Boschmann, Michael
name: Kramer, Achim
name: Michalsen, Andreas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: hydration
subject: religious
subject: intermittent fasting
subject: chronobiology
subject: water deprivation
subject: time-restricted eating
subject: fasting
subject: diurnal fasting
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Religiously motivated Baha'i fasting (BF) is a form of intermittent dry fasting celebrated by abstaining from food and drinks during daylight hours every year in March for 19 consecutive days. Aim: To test the safety and effects of BF on hydration, metabolism, and the circadian clock. Methods: Thirty-four healthy Baha'i volunteers (15 women) participated in this prospective, exploratory cohort study. Laboratory examinations were carried out in four study visits: before fasting (V0), in the third week of fasting (V1) as well as 3 weeks (V3) and 3 months (V4) after fasting. Data collection included blood and urine samples, anthropometric measurements and bioelectrical impedance analysis. At V0 and V1, 24- and 12-hour urine and serum osmolality were measured. At V0-V2, alterations in the circadian clock phase were monitored in 16 participants. Our study was augmented by an additional survey with 144 healthy Baha'i volunteers filling out questionnaires and with subgroups attending metabolic measurements (n = 11) and qualitative interviews (n = 13), the results of which will be published separately. Results: Exploratory data analysis revealed that serum osmolality (n = 34, p < 0.001) and 24-hour urine osmolality (n = 34, p = 0.003) decreased during daytime fasting but remained largely within the physiological range and returned to pre-fasting levels during night hours. BMI (body mass index), total body fat mass, and resting metabolic rate decreased during fasting (n = 34, p < 0.001), while body cell mass and body water appeared unchanged. The circadian phase estimated by transcript biomarkers of blood monocytes advanced by 1.1 h (n = 16, p < 0.005) during fasting and returned to pre-fasting values 3 weeks after fasting. Most observed changes were not detectable anymore 3 months after fasting. Conclusions: Results indicate that BF (Baha'i fasting) is safe, has no negative effects on hydration, can improve fat metabolism and can cause transient phase shifts of circadian rhythms. Trial Registration: https://www.clinicaltrials.gov/, identifier: NCT03443739.
Polynomial birth-death distribution approximation in Wasserstein distance
Creators: name: Xia, Aihua
name: Zhang, Fuxi
Publisher: name: arXiv
Year: 2008
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60F05, 60J27

description: The polynomial birth-death distribution (abbr. as PBD) on $\ci=\{0,1,2, >...\}$ or $\ci=\{0,1,2, ..., m\}$ for some finite $m$ introduced in Brown & Xia (2001) is the equilibrium distribution of the birth-death process with birth rates $\{α_i\}$ and death rates $\{β_i\}$, where $\a_i\ge0$ and $\b_i\ge0$ are polynomial functions of $i\in\ci$. The family includes Poisson, negative binomial, binomial and hypergeometric distributions. In this paper, we give probabilistic proofs of various Stein's factors for the PBD approximation with $\a_i=a$ and $\b_i=i+bi(i-1)$ in terms of the Wasserstein distance. The paper complements the work of Brown & Xia (2001) and generalizes the work of Barbour & Xia (2006) where Poisson approximation ($b=0$) in the Wasserstein distance is investigated. As an application, we establish an upper bound for the Wasserstein distance between the PBD and Poisson binomial distribution and show that the PBD approximation to the Poisson binomial distribution is much more precise than the approximation by the Poisson or shifted Poisson distributions.
description: 16 pages
Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing
Creators: name: Szymansky, Annabell
name: Kruetzfeldt, Louisa-Marie
name: Heukamp, Lukas C.
name: Hertwig, Falk
name: Theissen, Jessica
name: Deubzer, Hedwig E.
name: Willing, Eva-Maria
name: Menon, Roopika
name: Fuchs, Steffen
name: Thole, Theresa
name: Schulte, Stefanie
name: Schmelz, Karin
name: Künkele, Annette
name: Lang, Peter
name: Fuchs, Jörg
name: Eggert, Angelika
name: Eckert, Cornelia
name: Fischer, Matthias
name: Henssen, Anton G.
name: Rodriguez-Fos, Elias
name: Schulte, Johannes H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: neuroblastoma
subject: hybrid capture panel sequencing
subject: MYCN
subject: ALK
subject: risk stratification
subject: targeted therapies
subject: NB-HCPS assay
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: For many years, the risk-based therapy stratification of children with neuroblastoma has relied on clinical and molecular covariates. In recent years, genome analysis has revealed further alterations defining risk, tumor biology, and therapeutic targets. The implementation of a robust and scalable method for analyzing traditional and new molecular markers in routine diagnostics is an urgent clinical need. Here, we investigated targeted panel sequencing as a diagnostic approach to analyze all relevant genomic neuroblastoma risk markers in one assay. Our "neuroblastoma hybrid capture sequencing panel" (NB-HCSP) assay employs a technology for the high-coverage sequencing (>1000x) of 55 selected genes and neuroblastoma-relevant genomic regions, which allows for the detection of single nucleotide changes, structural rearrangements, and copy number alterations. We validated our assay by analyzing 15 neuroblastoma cell lines and a cohort of 20 neuroblastomas, for which reference routine diagnostic data and genome sequencing data were available. We observed a high concordance for risk markers identified by the NB-HSCP assay, clinical routine diagnostics, and genome sequencing. Subsequently, we demonstrated clinical applicability of the NB-HCSP assay by analyzing routine clinical samples. We conclude that the NB-HCSP assay may be implemented into routine diagnostics as a single assay that covers all essential covariates for initial neuroblastoma classification, extended risk stratification, and targeted therapy selection.
Regularity and mass conservation for discrete coagulation-fragmentation equations with diffusion
Creators: name: Cañizo, José A.
name: Desvillettes, Laurent
name: Fellner, Klemens
Publisher: name: arXiv
Year: 2009
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35B45, 35Q72, 82D60

description: We present a new a-priori estimate for discrete coagulation-fragmentation systems with size-dependent diffusion within a bounded, regular domain confined by homogeneous Neumann boundary conditions. Following from a duality argument, this a-priori estimate provides a global $L^2$ bound on the mass density and was previously used, for instance, in the context of reaction-diffusion equations. In this paper we demonstrate two lines of applications for such an estimate: On the one hand, it enables to simplify parts of the known existence theory and allows to show existence of solutions for generalised models involving collision-induced, quadratic fragmentation terms for which the previous existence theory seems difficult to apply. On the other hand and most prominently, it proves mass conservation (and thus the absence of gelation) for almost all the coagulation coefficients for which mass conservation is known to hold true in the space homogeneous case.
description: 24 pages
Mali - Land, climate, energy, agriculture and development: A study in the Sudano-Sahel Initiative for Regional Development, Jobs, and Food Security
Creators: name: Coulibaly, Ousmane Nafolo
name: Coulibaly, Ousmane Nafolo
Publisher: name: Unknown
Year: 2021
Subjects: subject: Labor and Human Capital
subject: Research and Development/Tech Change/Emerging Technologies
subject: Resource /Energy Economics and Policy
subject: Mali
subject: poverty
subject: agriculture
subject: economy
subject: climate change
subject: land degradation
subject: sustainable development

description: Mali is a Sub-Saharan African country with 19.1 million people. Almost half of this population lives in poverty, due to the dysfunction of activity sectors (agriculture, energy, education, employment, services, etc.). Natural resource management especially land and water together with corollaries remain one of the greatest challenges for this dryland region to sustainably face climate change, meet food demand and improve its economy. The social crisis (especially in the northern region) is significantly affecting development and human security as well. This study had been carried out to review the current state of affairs, key trends, problems, solutions and their implications for sustainable development of Mali under changing climate and the impacts of land degradation. Likewise, investment opportunities in the priority areas are highlighted in this report.
Involvement of CD26 in Differentiation and Functions of Th1 and Th17 Subpopulations of T Lymphocytes
Creators: name: Zhao, Xiangli
name: Wang, Wenhan
name: Zhang, Kai
name: Yang, Jingya
name: Fuchs, Hendrik
name: Fan, Hua
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: CD26
subject: T-lymphocyte subsets
subject: biomarkers
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: CD26, acting as a costimulator of T cell activation, plays an important role in the immune system. However, the role of CD26 in the differentiation of T cell subsets, especially of new paradigms of T cells, such as Th17 and Tregs, is not fully clarified. In the present study, the role of CD26 in T cell differentiation was investigated in vitro. CD26 expression was analyzed in the different subsets of human peripheral blood T lymphocytes after solid-phase immobilized specific anti-CD3 mAb stimulation. Here, the percentage of CD4(+) cells significantly increased and most of these cells were coexpressed with CD26, suggesting a close correlation of CD26 expression with the proliferation of CD4(+) cells. Subsequently, after immobilized anti-CD3 mAb stimulation, CD26 high-expressing cells (CD26(high)) were separated from CD26 low-expressing cells (CD26(low)) by magnetic cell sorting. We found that the percentages of cells secreting Th1 typical cytokines (IL-2, IFN-gamma) and Th17 typical cytokines (IL-6, IL-17, and IL-22) or expressing Th17 typical biomarkers (IL-23R, CD161, and CD196) in the CD26(high) group were markedly higher than in those in the CD26(low) group. In addition, a coexpression of CD26 with IL-2, IFN-gamma, IL-17, IL-22, and IL-23R in lymphocytes was demonstrated by fluorescence microscopy. These results provide direct evidence that the high expression of CD26 is accompanied by the differentiation of T lymphocytes into Th1 and Th17, indicating that CD26 plays a crucial role in regulating the immune response.
title: ÐÐ°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÐ½ÐºÐ° Ñ ÑÐµÐ»ÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð° Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð½ÑÑÐ°, ÐÑÐ¸Ð³Ð¾ÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð°Ñ ÑÑÐµÐ´Ð°
swot-Ð°Ð½Ð°Ð»Ð¸Ð·
ÑÐ¾ÑÐ³Ð¾Ð²Ð°Ñ Ð¿Ð¾Ð»Ð¸ÑÐ¸ÐºÐ°
ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ°Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ

description: Ð¦ÐµÐ»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð¼Ð°ÑÐºÐµÑÐ¸Ð½Ð³Ð¾Ð²Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¾ÑÐµÐ½ÐºÐ° ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¸ ÑÐµÐ½Ð´ÐµÐ½ÑÐ¸Ð¹ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÑÐ½ÐºÐ° Ð³Ð¾ÑÑÐ¸Ð½Ð¸ÑÐ½ÑÑ ÑÑÐ»ÑÐ³ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð°, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¹ Ð´Ð»Ñ Ð¼Ð¸Ð½Ð¸-Ð¾ÑÐµÐ»Ñ Â«Ð¡ÑÐ°ÑÐ°Ñ ÐÐµÐ½Ð°Â» Ð¿Ð¾ ÑÑÐ¸Ð»ÐµÐ½Ð¸Ñ ÐµÐµ Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¹ Ð½Ð° ÑÑÐ½ÐºÐµ. ÐÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ñ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð³Ð¾ÑÑÐ¸Ð½Ð¸ÑÑ Ð½Ð° ÑÑÐ½ÐºÐµ Ð³Ð¾ÑÑÐ¸Ð½Ð¸ÑÐ½ÑÑ ÑÑÐ»ÑÐ³ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð°, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð²ÐºÐ»ÑÑÐ°ÑÑ: Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ - Ð£Ð²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð·Ð°Ð³ÑÑÐ·ÐºÐ¸ Ð³Ð¾ÑÑÐ¸Ð½Ð¸ÑÑ Ð² Ð¿ÐµÑÐ¸Ð¾Ð´ Ð§Ð-2018: ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½ÑÑ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¸Ð¹; Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÐºÐ¾Ð½ÑÐµÐºÑÑÐ½Ð¾Ð¹ ÑÐµÐºÐ»Ð°Ð¼Ñ. Ð¡ÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ - ÐÐ¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿ÑÐµÐ´Ð¾ÑÑÐ°Ð²Ð»ÑÐµÐ¼ÑÑ ÑÑÐ»ÑÐ³: Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ðµ Ð¡ÐÐ Ð³Ð¾ÑÑÐ¸Ð½Ð¸ÑÐ½ÑÑ ÑÑÐ»ÑÐ³; Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ðµ ÑÐµÑÑÑÑÐ¾ÑÐ±ÐµÑÐµÐ³Ð°ÑÑÐ¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹. ÐÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÑÐµÐ½Ð¾Ð²Ð¾Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐ¸ÐºÐ¸ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ½Ð¾Ð²ÑÑ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¸Ð¹ Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ PR ÐºÐ°Ð¼Ð¿Ð°Ð½Ð¸Ð¸. ÐÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ Ð»Ð¾ÑÐ»ÑÐ½Ð¾ÑÑÐ¸ ÐºÐ»Ð¸ÐµÐ½ÑÐ¾Ð².
A Pilot Randomised Clinical Trial Comparing a Short-Term Perioperative Prophylaxis Regimen to a Long-Term Standard Protocol in Equine Colic Surgery
Creators: name: Stöckle, Sabita Diana
name: Kannapin, Dania A.
name: Kauter, Anne M. L.
name: Lübke-Becker, Antina
name: Walther, Birgit
name: Merle, Roswitha
name: Gehlen, Heidrun
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: colic
subject: laparotomy
subject: perioperative antibiotics
subject: surgical site infection
subject: colitis
subject: haemolytic anaemia
subject: horse
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background: For surgical interventions classified as clean or clean-contaminated, including laparotomy, guidelines in human and veterinary medicine recommend a short-term perioperative antibiotic prophylaxis (PAP). In equine colic surgery, however, PAP commonly exceeds 24 h. Objectives: The aim of this study was to compare a single-shot to a 5-day lasting PAP considering surgical site infections (SSI) and other adverse effects probably associated with the particular antimicrobial regimen. Study design: The study was designed as a randomised non-inferiority pilot study including horses subjected to colic surgery while receiving one of two distinct PAP regimens. Methods: All horses (n = 67) included in the study received the standard physical examination before and after surgery. Colic surgery was performed according to the current standard of the clinic. Horses were randomly assigned to two groups, receiving either the “single-shot” or the “5-day lasting” antibiotic prophylaxis. The “single-shot” group (n = 30) received penicillin and gentamicin only once before and, if needed, during surgery, whereas the “5-day lasting” group (n = 37) received antibiotics for five days. In addition to the standard laboratory examinations, serum amyloid A and fibrinogen were determined preoperatively and during five days after surgery. SSI, postoperative colitis and haemolytic anaemia were classified as postoperative complications potentially related to antibiotic use. Results: The outcome of this preliminary non-inferiority clinical trial showed that the occurrence of postoperative adverse events (i.e., SSI, postoperative colitis and haemolytic anaemia) lacked significant differences between the study groups. Main limitations: The main limitations of this study are the limited group sizes and our inability to blind the study. Conclusions: Single-shot PAP seems to be an alternative approach considering the 5-day lasting protocol commonly used in equine abdominal surgery. However, a proper hygiene management together with a close clinical and laboratory monitoring of the equine patient is indispensable.
Dilepton and Four-Lepton Signals at the LHC in the Littlest Higgs Model with T-parity Violation
Creators: name: Mukhopadhyay, Satyanarayan
name: Mukhopadhyaya, Biswarup
name: Nyffeler, Andreas
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the presence of the T-parity violating Wess-Zumino-Witten (WZW) anomaly term, the otherwise stable heavy photon A_H in the Littlest Higgs model with T-parity (LHT) decays to either Standard Model (SM) gauge boson pairs, or to SM fermions via loop diagrams. We make a detailed study of the collider signatures where the A_H can be reconstructed from invariant mass peaks in the opposite sign same flavor dilepton or the four-lepton channels. This enables us to obtain information about the fundamental symmetry breaking scale f in the LHT and thereby the low-lying mass spectrum of the theory. In addition, indication of the presence of the WZW term gives us hints of the possible UV completion of the LHT via strong dynamics. The crucial observation is that the sum of all production processes of heavy T-odd quark pairs has a sizeable cross-section at the LHC and these T-odd particles eventually all cascade decay down to the heavy photon A_H. We show that for certain regions of the parameter space with either a small f of around 500 GeV or relatively light T-odd quarks with a mass of around 400 GeV, one can reconstruct the A_H even at the early LHC run with \sqrt{s}=10 TeV and a modest integrated luminosity of 200 pb^{-1}. At \sqrt{s} = 14 TeV and with an integrated luminosity of 30 fb^{-1}, it is possible to cover a large part of the typical parameter space of the LHT, with the scale f up to 1.5 TeV and with T-odd quark masses almost up to 1 TeV. In this region of the parameter space, the mass of the reconstructed A_H ranges from 66 GeV to 230 GeV.
description: 35 pages, 4 figures; v2: additional multiple hard jets included in background simulation using ALPGEN, main conclusions unchanged, references added, version as published in JHEP.
title: ÐÐ°Ð·Ð¾Ð²ÑÐ¹ ÐºÑÑÑ Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ°. ÐÐ±ÑÑÐµÐ½Ð¸Ðµ Ð»ÐµÐºÑÐ¸ÐºÐµ (1 Ð¸ 2 ÑÐµÐ¼ÐµÑÑÑÑ)
title: ÑÑÐµÐ±Ð½Ð¾-Ð¼ÐµÑÐ¾Ð´Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: ÐÐ¸ÐºÐ¾Ð½Ð¾Ð²Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
name: ÐÐµÑÐµÐ±ÐºÐ¸Ð½Ð°, ÐÐ»ÑÐ³Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¸Ð¹ ÑÐ·ÑÐº
Ð»ÐµÐºÑÐ¸ÐºÐ°
Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ
ÑÑÐµÐ±Ð½Ð¸ÐºÐ¸ Ð¸ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ñ Ð´Ð»Ñ Ð¸Ð½Ð¾ÑÑÑÐ°Ð½ÑÐµÐ²

description: Ð£ÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ Ð½Ð°ÑÐµÐ»ÐµÐ½Ð¾ Ð½Ð° Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ Ð»ÐµÐºÑÐ¸ÐºÐµ Ð°Ð½Ð³Ð»Ð¸Ð¹ÑÐºÐ¾Ð³Ð¾ ÑÐ·ÑÐºÐ° Ð¸Ð½Ð¾ÑÑÑÐ°Ð½Ð½ÑÑ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð² ÐÐÐÐ­Ð¸Ð¢ Ð² Ð¿ÐµÑÐ²Ð¾Ð¼ Ð¸ Ð²ÑÐ¾ÑÐ¾Ð¼ ÑÐµÐ¼ÐµÑÑÑÐµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ñ Ð² Ð¡ÐÐ±ÐÐ£ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾. ÐÐ°Ð½Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ ÑÐ¾ÑÑÐ¾Ð¸Ñ Ð¸Ð· Ð¿ÑÑÐ¸ ÑÐ°Ð·Ð´ÐµÐ»Ð¾Ð², ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑ Ð¸ Ð´Ð¾Ð¿Ð¾Ð»Ð½ÑÑÑ ÑÐ°Ð·Ð´ÐµÐ»Ñ ÑÑÐµÐ±Ð½Ð¸ÐºÐ° Language Leader Intermediate. Ð Ð¿Ð¾ÑÐ¾Ð±Ð¸Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð»Ð¸Ð½Ð³Ð²Ð¾-ÐºÐ»Ð°ÑÑÐ¸ÑÐ¸ÑÐ¸ÑÑÑÑÐ¸Ðµ, ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½Ð¾-ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ½ÑÐµ, Ð¿Ð¾Ð¸ÑÐºÐ¾Ð²Ð¾-Ð¾ÑÐ¸ÐµÐ½ÑÐ°ÑÐ¸Ð¾Ð½Ð½ÑÐµ, Ð´Ð¸ÑÐºÑÑÑÐ¸Ð²Ð½Ð¾-Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ½ÑÐµ, Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð²Ð½Ð¾-Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¿ÑÐ°Ð¶Ð½ÐµÐ½Ð¸Ñ.
Supplementary Video - Unsupervised Coordinate-Based Video Denoising
Creators: Dineshchandar Ravichandran
Reda Chalhoub
Peter Kalivas
Feng Luo
Nianyi Li
Publisher: name: IEEE Signal Processing Society
Year: 2024

description: In this paper, we introduce a novel unsupervised video denoising deep learning approach that can help to mitigate data scarcity issues and shows robustness against different noise patterns, enhancing its broad applicability. Our method comprises three modules: a Feature generator creating features maps, a Denoise-Net generating denoised but slightly blurry reference frames, and a Refine-Net re-introducing high-frequency details. By leveraging the coordinate-based network, we can greatly simplify the network structure while preserving high-frequency details in the denoised video frames. 
Extensive experiments on both simulated and real-captured demonstrate that our method can effectively denoise real-world calcium imaging video sequences without prior knowledge of noise models and data augmentation during training.
Approximating the minimum length of synchronizing words is hard
Creators: name: Berlinkov, M. V.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: Computational Complexity (cs.CC)
subject: FOS: Computer and information sciences
subject: F.1.1; F.4.3

description: We prove that, unless $\mathrm{P}=\mathrm{NP}$, no polynomial algorithm can approximate the minimum length of \sws for a given \san within a constant factor.
description: 12 pages, 1 figure
The Complexity of Generalized Satisfiability for Linear Temporal Logic
Creators: name: Bauland, Michael
name: Schneider, Thomas
name: Schnoor, Henning
name: Schnoor, Ilka
name: Vollmer, Heribert
Publisher: name: arXiv
Year: 2008
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: F.4.1

description: In a seminal paper from 1985, Sistla and Clarke showed that satisfiability for Linear Temporal Logic (LTL) is either NP-complete or PSPACE-complete, depending on the set of temporal operators used. If, in contrast, the set of propositional operators is restricted, the complexity may decrease. This paper undertakes a systematic study of satisfiability for LTL formulae over restricted sets of propositional and temporal operators. Since every propositional operator corresponds to a Boolean function, there exist infinitely many propositional operators. In order to systematically cover all possible sets of them, we use Post's lattice. With its help, we determine the computational complexity of LTL satisfiability for all combinations of temporal operators and all but two classes of propositional functions. Each of these infinitely many problems is shown to be either PSPACE-complete, NP-complete, or in P.
Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis
Creators: name: Wetzel, Alexandra
name: Scholtka, Bettina
name: Schumacher, Fabian
name: Rawel, Harshadrai
name: Geisendörfer, Birte
name: Kleuser, Burkhard
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: decitabine
subject: DNMT inhibitor
subject: EBI3
subject: inhibitory cytokines
subject: interleukin-35
subject: TNFa
subject: Ulcerative colitis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Ulcerative colitis (UC), a severe chronic disease with unclear etiology that is associated with increased risk for colorectal cancer, is accompanied by dysregulation of cytokines. Epstein–Barr virus-induced gene 3 (EBI3) encodes a subunit in the unique heterodimeric IL-12 cytokine family of either pro- or anti-inflammatory function. After having recently demonstrated that upregulation of EBI3 by histone acetylation alleviates disease symptoms in a dextran sulfate sodium (DSS)-treated mouse model of chronic colitis, we now aimed to examine a possible further epigenetic regulation of EBI3 by DNA methylation under inflammatory conditions. Treatment with the DNA methyltransferase inhibitor (DNMTi) decitabine (DAC) and TNFα led to synergistic upregulation of EBI3 in human colon epithelial cells (HCEC). Use of different signaling pathway inhibitors indicated NFκB signaling was necessary and proportional to the synergistic EBI3 induction. MALDI-TOF/MS and HPLC-ESI-MS/MS analysis of DAC/TNFα-treated HCEC identified IL-12p35 as the most probable binding partner to form a functional protein. EBI3/IL-12p35 heterodimers (IL-35) induce their own gene upregulation, something that was indeed observed in HCEC cultured with media from previously DAC/TNFα-treated HCEC. These results suggest that under inflammatory and demethylating conditions the upregulation of EBI3 results in the formation of anti-inflammatory IL-35, which might be considered as a therapeutic target in colitis.
Quantum Fields on Noncommutative Spacetimes: Theory and Phenomenology
Creators: name: Balachandran, Aiyalam P.
name: Ibort, Alberto
name: Marmo, Giuseppe
name: Martone, Mario
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In the present work we review the twisted field construction of quantum field theory on noncommutative spacetimes based on twisted Poincaré invariance. We present the latest development in the field, in particular the notion of equivalence of such quantum field theories on a noncommutative spacetime, in this regard we work out explicitly the inequivalence between twisted quantum field theories on Moyal and Wick-Voros planes; the duality between deformations of the multiplication map on the algebra of functions on spacetime $\mathscr{F}(\mathbb{R}^4)$ and coproduct deformations of the Poincaré-Hopf algebra $H\mathscr{P}$ acting on~$\mathscr{F}(\mathbb{R}^4)$; the appearance of a nonassociative product on $\mathscr{F}(\mathbb{R}^4)$ when gauge fields are also included in the picture. The last part of the manuscript is dedicated to the phenomenology of noncommutative quantum field theories in the particular approach adopted in this review. CPT violating processes, modification of two-point temperature correlation function in CMB spectrum analysis and Pauli-forbidden transition in ${\rm Be}^4$ are all effects which show up in such a noncommutative setting. We review how they appear and in particular the constraint we can infer from comparison between theoretical computations and experimental bounds on such effects. The best bound we can get, coming from Borexino experiment, is $\gtrsim 10^{24}$ TeV for the energy scale of noncommutativity, which corresponds to a length scale $\lesssim 10^{-43}$ m. This bound comes from a different model of spacetime deformation more adapted to applications in atomic physics. It is thus model dependent even though similar bounds are expected for the Moyal spacetime as well as argued elsewhere.
Straight Line Orbits in Hamiltonian Flows
Creators: name: Howard, J. E.
name: Meiss, J. D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We investigate periodic straight-line orbits (SLO) in Hamiltonian force fields using both direct and inverse methods. A general theorem is proven for natural Hamiltonians quadratic in the momenta in arbitrary dimension and specialized to two and three dimension. Next we specialize to homogeneous potentials and their superpositions, including the familiar Hénon-Heiles problem. It is shown that SLO's can exist for arbitrary finite superpositions of $N$-forms. The results are applied to a family of generalized Hénon-Heiles potentials having discrete rotational symmetry. SLO's are also found for superpositions of these potentials.
description: laTeX with 6 figures
Nonlinear Evolution of Axisymmetric Twisted Flux Tubes in the Solar Tachocline
Creators: name: Hollerbach, R.
name: Cally, P. S.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We numerically study the evolution of magnetic fields and fluid flows in a thin spherical shell. We take the initial field to be a latitudinally confined, predominantly toroidal flux tube. For purely toroidal, untwisted flux tubes, we recover previously known radial-shredding instabilities, and show further that in the nonlinear regime these instabilities can very effectively destroy the original field. For twisted flux tubes, including also a poloidal component, there are several possibilities, including the suppression of the radial-shredding instability, but also a more directly induced evolution, brought about because twisted flux tubes in general are not equilibrium solutions of the governing equations.
description: final version as published in journal
Expression of MICA in Zero Hour Biopsies Predicts Graft Survival After Liver Transplantation
Creators: name: Resch, Thomas
name: Hackl, Hubert
name: Esser, Hannah
name: Günther, Julia
name: Schwelberger, Hubert
name: Ritschl, Paul Viktor
name: Ebner, Susanne
name: Maglione, Manuel
name: Mellitzer, Vanessa
name: Biebl, Matthias
name: Öllinger, Robert
name: Zoller, Heinz
name: Schneeberger, Stefan
name: Kotsch, Katja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: biomarker
subject: liver transplantation
subject: graft quality assessment
subject: graft survival
subject: marginal donor
subject: donor risk index
subject: mortality
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In search for novel biomarkers to assess graft quality, we investigated whether defined candidate genes are predictive for outcome after liver transplantation (LT). Zero-hour liver biopsies were obtained from 88 livers. Gene expression of selected candidate markers was analyzed and correlated with clinical parameters as well as short and long-term outcomes post LT. Whereas both, the calculated Eurotransplant Donor-Risk-Index and the donor body mass index, had either a poor or no predictive value concerning serum levels indicative for liver function (ALT, AST, GGT, bilirubin) after 6 months, chronological donor age was weakly predictive for serum bilirubin (AUC=0.67). In contrast, the major histcompatibility complex class I related chain A (MICA) mRNA expression demonstrated a high predictive value for serum liver function parameters revealing an inverse correlation (e.g. for ALT: 3 months p=0.0332; 6 months p=0.007, 12 months 0.0256, 24 months p=0.0098, 36 months, p=0.0153) and proved significant also in a multivariate regression model. Importantly, high expression of MICA mRNA revealed to be associated with prolonged graft survival (p=0.024; log rank test) after 10 years of observation, whereas low expression was associated with the occurrence of death in patients with transplant related mortality (p=0.031). Given the observed correlation with short and long-term graft function, we suggest MICA as a biomarker for pre-transplant graft evaluation.
Spontaneous non-steady magnetic reconnection within the solar environment
Creators: name: Bettarini, Lapo
name: Lapenta, Giovanni
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: This work presents a 2.5-dimensional simulation study of the instability of current-sheets located in a medium with a strong density variation along the current layer. The initial force-free configuration is observed to undergo a two-stage evolution consisting of an abrupt regime transition from a slow to a fast reconnection process leading the system to a final chaotic configuration. Yet, the onset of the fast phase is not determined by the presence of any anomalous enhancement in plasma's local resistivity, but rather is the result of a new mechanism discovered in Lapenta (2008)* and captured only when sufficient resolution is present. Hence, the effects of the global resistivity, the global viscosity and the plasma beta on the overall dynamics are considered. This mechanism allowing the transition from slow to fast reconnection provides a simple but effective model of several processes taking place within the solar atmosphere from the high chromosphere up to the low corona. In fact, the understanding of a spontaneous transition to a self-feeding fast reconnection regime as well as its macroscopic evolution is the first and fundamental step to produce realistic models of all those phenomena requiring fast (and high power) triggering events (* Lapenta G. 2008, Phys. Rev. Lett., 100, 235001).
description: 29 pages, 10 figures