cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Short screening tools for risky drinking in Aboriginal and Torres Strait Islander Australians: modified AUDIT-C and a new approach
Creators: name: Lee, Kylie
name: Conigrave, James H
name: Wilson, Scott
name: Perry, Jimmy
name: Callinan, Sarah
name: Room, Robin
name: Chikritzhs, Tanya N
name: Slade, Tim
name: Hayman, Noel
name: Leggat, Geoffrey
name: Conigrave, Katherine M
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: BACKGROUND: Alcohol consumption among Indigenous Australians can involve a stop-start pattern of drinking, with consumption well above recommended guidelines on each occasion. Such intermittent drinking patterns can make screening for risky drinking difficult. This study evaluates the ability of several short alcohol screening tools, contained in the Grog Survey Application, to detect short- or long-term risky drinking as defined by Australian guidelines. Tested tools include a modification of Alcohol Use Disorders Identification Test-Consumption (AUDIT-Cm). METHODS: Alcohol consumption was assessed in current drinkers in the past year (n = 184) using AUDIT-Cm and using the last four drinking occasions (Finnish method). Sensitivity and specificity were assessed relative to the Finnish method, for how AUDIT-Cm score (3 + for women, 4 + for men), and how subsets of AUDIT-Cm questions (AUDIT-1m and AUDIT-2m; and AUDIT-3mV alone) were able to determine short- or long-term risk from drinking. Responses to AUDIT-Cm were used to calculate the average standard drinks consumed per day, and the frequency at which more than four standard drinks were consumed on single occasions. Finally, shorter versions of the Finnish method (1, 2, or 3 occasions of drinking) were compared to the full Finnish method, by examining the percentage of variance retained by shorter versions. RESULTS: AUDIT-Cm has a high sensitivity in detecting at-risk drinking compared with the Finnish method (sensitivity = 99%, specificity = 67%). The combination of AUDIT-1m and AUDIT-2m was able to classify the drinking risk status for all but four individuals in the same way as the Finnish method did. For the Finnish method, two drinking sessions to calculate drinks per drinking occasion, and four to calculate frequency resulted in nearly identical estimates to data on all four of the most recent drinking occasions (r2 = 0.997). CONCLUSIONS: The combination of AUDIT-1m and AUDIT-2m may offer advantages as a short screening tool, over AUDIT-3mV, in groups where intermittent and high per occasion drinking is common. As an alternative to the full Finnish method, the quantity consumed on the last two occasions and timing of the last four occasions may provide a practical short screening tool.
Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells
Creators: name: Wen, Jing
name: Li, Xin
name: Zhao, Qing-Xia
name: Yang, Xiao-Fan
name: Wu, Meng-Li
name: Yan, Qihong
name: Chang, Junbiao
name: Wang, Haikun
name: Jin, Xia
name: Su, Xiao
name: Deng, Kai
name: Chen, Ling
name: Wang, Jian-Hua
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) has been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune responses. Identification of key cellular pathways that modulate HIV-1 latency helps develop efficient LRAs. In this study, we demonstrate that the Wnt downstream β-catenin/TCF1 pathway is a crucial modulator for HIV-1 latency. The pharmacological activation of the β-catenin/TCF1 pathway with glycogen synthase kinase-3 (GSK3) inhibitors promoted transcription of HIV-1 proviral DNA and reactivated latency in CD4+ T cells; the GSK3 kinase inhibitor 6-bromoindirubin-3′-oxime (6-BIO)- induced HIV-1 reactivation was subsequently confirmed in resting CD4+ T cells from cART-suppressed patients and SIV-infected rhesus macaques. These findings advances our understanding of the mechanisms responsible for viral latency, and provides the potent LRA that can be further used in conjunction of immunotherapies to eradicate viral reservoirs.
Effectiveness Of A Pedometer-Based Physical Activity Program On Blood Pressure Control Among Adults With Hypertension In A Tertiary Hospital In Quezon City, Philippines
Creators: name: Macazo, Mary Lorelei
Publisher: name: Zenodo
Year: 2023
Subjects: Pedometer
Hypertension
Effectiveness
Physical Activity

description: Abstract

The main purpose of the study is to determine the effectiveness of a pedometer- based walking program as a physical activity towards blood pressure control among adults with hypertension who are employed in a tertiary hospital. The study employed a quasi-experimental design, specifically a one-group before-after design wherein the dependent variable (i.e., blood pressure) was measured before (i.e., pretest) and after the intervention (i.e., posttest). Measures used in the pretest and the posttest are the same, and changes in the dependent variable from pretest to posttest are interpreted to reflect the changes brought by the intervention (pedometer-based physical activity program). There was a total of 39 participants that participated in the program, most of them are male adults with history of hypertension, have smoking habits, and some have diabetes mellitus. Study shows significant increase in blood pressure control among adults with Hypertension in the Pedometer-Based Physical Activity program as compared to those who were not. The use of pedometer is a factor that helped them continue the program and achieve the goal of 10,000 steps since they were able to track their progress. A pedometer-based walking program with daily tracking, is effective in promoting walking and improving positive affect of blood pressure control among patients with hypertension.
COVID-19 prevention measures reduce dengue spread in Yunnan Province, China, but do not reduce established outbreak
Creators: name: Sheng, Z.Y.
name: Li, M.
name: Yang, R.
name: Liu, Y.H.
name: Yin, X.X.
name: Mao, J. R.
name: Brown, Heidi E.
name: An, J.
name: Zhou, H.N.
name: Wang, P.G.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The COVID-19 pandemic and measures against it provided a unique opportunity to understand the transmission of other infectious diseases and to evaluate the efficacy of COVID-19 prevention measures on them. Here we show a dengue epidemic in Yunnan, China, during the pandemic of COVID-19 was dramatically reduced compared to non-pandemic years and, importantly, spread was confined to only one city, Ruili. Three key features characterized this dengue outbreak: (i) the urban-to-suburban spread was efficiently blocked; (ii) the scale of epidemic in urban region was less affected; (iii) co-circulation of multiple strains was attenuated. These results suggested that countermeasures taken during COVID-19 pandemic are efficient to prevent dengue transmission between cities and from urban to suburban, as well to reduce the co-circulation of multiple serotypes or genotypes. Nevertheless, as revealed by the spatial analysis, once the dengue outbreak was established, its distribution was very stable and resistant to measures against COVID-19, implying the possibility to develop a precise prediction method.
A wooden disc wheel from Dolanog, Powys
Creators: name: Redknap, Mark
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 257-264
description: A small, one-piece oak disc wheel was found during the excavation of a pond at Wern-y-Wîg, Dolanog, near Welshpool, Powys, in 1985. Originally thought to be potentially of prehistoric date has been shown to probably date to the period AD 1400-1650 and may have come from a simple horse-drawn cart, a manure cart, or a wheelbarrow. Though much more recent than anticipated, the wheel is nonetheless the earliest wooden wheel recorded from Wales.
Additional file 2 of Exploring hub pyroptosis-related genes, molecular subtypes, and potential drugs in ankylosing spondylitis by comprehensive bioinformatics analysis and molecular docking
Creators: name: Li, Xin
name: Li, Xiangying
name: Wang, Hongqiang
name: Zhao, Xiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Supplementary file 3. Immune analysis. (A) The relative infiltration abundance of immune cells between AS and control. (B) Differences in immune infiltration between AS and control.
William Williams, an eighteenth-century Welsh land surveyor
Creators: name: Silvester, Robert
name: Hawkins, John
Publisher: name: Archaeology Data Service
Year: 2025

description: Archaeologia Cambrensis, 169, 265-290
description: William Williams, born in Flintshire and active between 1718 and 1736 , is on present evidence the earliest Welsh professional land surveyor known by name. Early in his career he was engaged in the surveying of smaller estates in north Wales and also in the preparation of a new map of the counties of Flintshire and Denbighshire for subscribers whose coats of arms were depicted around its border. Searching for work, he moved to Oxford between 1724-33 and became involved with the production of the Oxford University Almanack and Oxonia Depicta. In the years before his death in 1738 he returned to work in north Wales and the borderland counties and was commissioned to survey of a number of larger estates.
Freeze it all! An IPM case study of the Angelo State Natural History Collections
Creators: name: Brady, Serina
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Freeze it all! An IPM case study of the Angelo State Natural History Collections by Serina Brady of Angelo State Natural History Collections San Angelo United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
title: Synthesis and reactivity of novel (NHC)gold(I) complexes
Creators: name: Patrick, Scott R.
Publisher: name: University of St Andrews
publisherIdentifier: https://ror.org/02wn5qz54
publisherIdentifierScheme: ROR
Year: 2014

description: The fields of N-heterocyclic carbenes and homogeneous gold catalysis have experienced tremendous growth within the last two decades. In addition, the combination of these fields to give NHC-gold complexes has delivered superior stability and reactivity, allowing the isolation of new reactive species and a better understanding of the fundamental chemistry. The work presented in this thesis attempts to synthesise novel NHC-gold complexes and document their reactivities. The main themes discussed in this work are: (a) the understanding and avoidance of silver additives in gold-mediated transformations; and (b) the study of different NHCs to provide optimal sterics and electronics for a given application. In Chapter 2, the reported “Gold(I)-Mediated C-H Activation of Arenes” is investigated. The role of each additive is assessed, and in particular the reliance on silver salts is considered. An NHC ligand was used to stabilise reactive intermediates, which provided new insights into the function of the silver additive. Gold(I) hydroxides are repeatedly shown to be invaluable synthetic equivalents, as well as key intermediates in silver-free protocols. Chapter 3 details numerous attempts to synthesise [Au(OH)(NHC)] complexes that are stable, pure and in high yields. Chapter 4 documents the synthesis of gold species featuring the ITent family of NHC ligands. Their highly flexible steric bulk is investigated by crystallographic studies, and is believed to contribute to their relatively high stabilities. Chapter 5 describes the use of the newly synthesised [Au(OH)(NHC)] complexes to generate mono- and bifluoride species. The reaction conditions were then optimised in order to maximise yields and regioselectivities. Finally, Chapter 6 examines the use of NHC selenium adducts to measure the π-accepting ability of these ligands. These are then coordinated to gold, whereupon different geometries are observed depending on the nature of the NHC.
Additional file 7 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 7: CpG sites identifiedin linear mixed models testing associations between maternal fasting glucose and DNAm measured in cord blood and blood at 5 years of age; Table presenting CpG sites, including their chromosome number, genomic position, and associated gene, identified at suggestive P < 10−5 in linear mixed models testing associations between maternal fasting glucose and DNAm measured in cord blood and blood at 5 years of age.
Sequence duplication in 3′ UTR modulates virus replication and virulence of Japanese encephalitis virus
Creators: name: Zhang, Qiu-Yan
name: Liu, Si-Qing
name: Li, Xiao-Dan
name: Li, Jia-Qi
name: Zhang, Ya-Nan
name: Deng, Cheng-Lin
name: Zhang, Hong-Lei
name: Li, Xu-Fang
name: Fang, Chun-Xiao
name: Yang, Feng-Xia
name: Zhang, Bo
name: Xu, Yi
name: Ye, Han-Qing
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Japanese encephalitis virus (JEV), an important neurotropic pathogen, belongs to the genus Flavivirus of the family Flaviviridae and has caused huge threat to public health. It is still obscure regarding the functions of stem-loop (SL) and dumbbell (DB) domains of JEV 3′ UTR in viral replication and virulence. In the current study, using the infectious clone of JEV SA14 strain as a backbone, we constructed a series of deletion mutants of 3′ UTR to investigate their effects on virus replication. The results showed that partial deletions within SL or DB domain had no apparent effects on virus replication in both mammalian (BHK-21) and mosquito (C6/36) cells, suggesting that they were not involved in viral host-specific replication. However, the entire SL domain deletion (ΔVR) significantly reduced virus replication in both cell lines, indicating the important role of the complete SL domain in virus replication. The revertant of ΔVR mutant virus was obtained by serial passage in BHK-21 cells that acquired a duplication of DB domain (DB-dup) in the 3′ UTR, which greatly restored virus replication as well as the capability to produce the subgenomic flavivirus RNAs (sfRNAs). Interestingly, the DB-dup mutant virus was highly attenuated in C57BL/6 mice despite replicating similar to WT JEV. These findings demonstrate the significant roles of the duplicated structures in 3′ UTR in JEV replication and provide a novel strategy for the design of live-attenuated vaccines.
CORRELATION ANALYSIS OF REACTIVITY IN THE OXIDATION OF SUBSTITUTED BENZALDEHYDES BY BIS[DIPYRIDINESILVER(I)]DICHROMATE
Creators: name: Soni, U
name: Yajurvedi, D.
name: Vyas, S.
name: Prakash, O.
name: Sharma, Pradeep K.
Publisher: name: European Chemical Bulletin
Year: 2015

description: Oxidation of thirty six monosubstituted benzaldehydes by bis[dipyridinesilver (I)] dichromate (BDSD) in dimethylsulphoxide (DMSO), leads to the formation of corresponding benzoic acids.  The reaction is of  first order with respect to BDSD. A Michaelis-Menten type kinetics was observed with respect to the reactants. The reaction is promoted by hydrogen ions; the hydrogen‑ion dependence has the form kobs= a + b [H+]. The oxidation of [2H]benzaldehyde (PhCDO) exhibited a  substantial primary  kinetic   isotope effect. The reaction was studied in nineteen different organic solvents and the effect of solvent was analysed using Taft's and Swain's multi-parametric equations.  The rates of the oxidation of para‑ and meta‑substituted benzaldehydes showed excellent correlation  in terms of  Charton’s triparametric LDR equation, whereas the oxidation of ortho-substituted benzaldehydes were correlated well with tetraperametric LDRS equation. The oxidation of para-substituted benzaldehydes is more susceptible to the delocalized effect than is the oxidation of ortho- and meta- substituted compounds, which display a greater dependence on the field effect. The positive value of h suggests the presence of an electron-deficient reaction centre in the rate-determining step. The reaction is subjected to steric acceleration by the ortho-substituents. A suitable mechanism has been proposed.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
Short screening tools for risky drinking in Aboriginal and Torres Strait Islander Australians: modified AUDIT-C and a new approach
Creators: name: Lee, Kylie
name: Conigrave, James
name: Wilson, Scott
name: Perry, Jimmy
name: Callinan, Sarah
name: Room, Robin
name: Chikritzhs, Tanya N
name: Slade, Tim
name: Hayman, Noel
name: Leggat, Geoffrey
name: Conigrave, Katherine M
Publisher: name: La Trobe
Year: 2024

description: BACKGROUND: Alcohol consumption among Indigenous Australians can involve a stop-start pattern of drinking, with consumption well above recommended guidelines on each occasion. Such intermittent drinking patterns can make screening for risky drinking difficult. This study evaluates the ability of several short alcohol screening tools, contained in the Grog Survey Application, to detect short- or long-term risky drinking as defined by Australian guidelines. Tested tools include a modification of Alcohol Use Disorders Identification Test-Consumption (AUDIT-Cm). METHODS: Alcohol consumption was assessed in current drinkers in the past year (n = 184) using AUDIT-Cm and using the last four drinking occasions (Finnish method). Sensitivity and specificity were assessed relative to the Finnish method, for how AUDIT-Cm score (3 + for women, 4 + for men), and how subsets of AUDIT-Cm questions (AUDIT-1m and AUDIT-2m; and AUDIT-3mV alone) were able to determine short- or long-term risk from drinking. Responses to AUDIT-Cm were used to calculate the average standard drinks consumed per day, and the frequency at which more than four standard drinks were consumed on single occasions. Finally, shorter versions of the Finnish method (1, 2, or 3 occasions of drinking) were compared to the full Finnish method, by examining the percentage of variance retained by shorter versions. RESULTS: AUDIT-Cm has a high sensitivity in detecting at-risk drinking compared with the Finnish method (sensitivity = 99%, specificity = 67%). The combination of AUDIT-1m and AUDIT-2m was able to classify the drinking risk status for all but four individuals in the same way as the Finnish method did. For the Finnish method, two drinking sessions to calculate drinks per drinking occasion, and four to calculate frequency resulted in nearly identical estimates to data on all four of the most recent drinking occasions (r2 = 0.997). CONCLUSIONS: The combination of AUDIT-1m and AUDIT-2m may offer advantages as a short screening tool, over AUDIT-3mV, in groups where intermittent and high per occasion drinking is common. As an alternative to the full Finnish method, the quantity consumed on the last two occasions and timing of the last four occasions may provide a practical short screening tool.
From bee to bone - theory and praxis of a large scale collection move
Creators: name: Kirschey, Lukas
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on From bee to bone - theory and praxis of a large scale collection move by Head Of Collection Management Entomology Lukas Kirschey of Head Of Collection Management Entomology Museum Für Naturkunde Berlin Berlin Germany for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Additional file 9 of Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age
Creators: name: Taschereau, Amélie
name: Thibeault, Kathrine
name: Allard, Catherine
name: Juvinao-Quintero, Diana
name: Perron, Patrice
name: Lutz, Sharon M.
name: Bouchard, Luigi
name: Hivert, Marie-France
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Mental Health

description: Additional file 9: CpG sites identified in linear mixed models testing associations between maternal 2h-glucose post-OGTT and DNAm measured in cord blood and blood at 5 years of age; Table presenting CpG sites, including their chromosome number, genomic position, and associated gene, identified at suggestive P < 10−5 in linear mixed models testing associations between maternal 2h post-OGTT glucose levels and DNAm measured in cord blood and blood at 5 years of age.
The genome of the Black Bengal goat (Capra hircus)
Creators: name: Siddiki, AZ
name: Baten, A
name: Billah, M
name: Alam, MAU
name: Shawrob, KSM
name: Saha, S
name: Chowdhury, M
name: Rahman, AH
name: Stear, Michael
name: Miah, G
name: Kumkum, M
name: Islam, MS
name: Hossain, MA
name: Mollah, AKMM
name: Khan, MKI
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences

description: Objectives: Black Bengal goat (Capra hircus), a member of the Bovidae family with the unique traits of high prolificacy, skin quality and low demand for food is the most socioeconomically significant goat breed in Bangladesh. Furthermore, the aptitude of adaptation and disease resistance capacity of it is highly notable which makes its whole genome information an area of research interest. Data description: The genomic DNA of a local (Chattogram, Bangladesh) healthy male Black Bengal goat (Capra hircus) was extracted and then sequenced. Sequencing was completed using the Illumina HiSeq 2500 sequencing platform and the draft assembly was generated using the "ARS1" genome as the reference. MAKER gene annotation pipeline was utilized to annotate 26,458 gene models. Genome completeness was assessed using BUSCO (Benchmarking Universal Single-Copy Orthologs) which showed 82.5% completeness of the assembled genome.
Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus serotypes 1–4
Creators: name: Tamura, Tomokazu
name: Zhang, Jiayu
name: Madan, Vrinda
name: Biswas, Abhishek
name: Schwoerer, Michael P.
name: Cafiero, Thomas R.
name: Heller, Brigitte L.
name: Wang, Wei
name: Ploss, Alexander
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Dengue is caused by four genetically distinct viral serotypes, dengue virus (DENV) 1-4. Following transmission by Aedes mosquitoes, DENV can cause a broad spectrum of clinically apparent disease ranging from febrile illness to dengue hemorrhagic fever and dengue shock syndrome. Progress in the understanding of different dengue serotypes and their impacts on specific host-virus interactions has been hampered by the scarcity of tools that adequately reflect their antigenic and genetic diversity. To bridge this gap, we created and characterized infectious clones of DENV1–4 originating from South America, Africa, and Southeast Asia. Analysis of whole viral genome sequences of five DENV isolates from each of the four serotypes confirmed their broad genetic and antigenic diversity. Using a modified circular polymerase extension reaction (CPER), we generated de novo viruses from these isolates. The resultant clones replicated robustly in human and insect cells at levels similar to those of the parental strains. To investigate in vivo properties of these genetically diverse isolates, representative viruses from each DENV serotype were administered to NOD Rag1−/−, IL2rgnull Flk2−/− (NRGF) mice, engrafted with components of a human immune system. All DENV strains tested resulted in viremia in humanized mice and induced cellular and IgM immune responses. Collectively, we describe here a workflow for rapidly generating de novo infectious clones of DENV – and conceivably other RNA viruses. The infectious clones described here are a valuable resource for reverse genetic studies and for characterizing host responses to DENV in vitro and in vivo.
FINAL_Supplement_2 – Supplemental material for Interpretations of the journalistic field: A systematic analysis of how journalism scholarship appropriates Bourdieusian thought
Creators: name: Maares, Phoebe
name: Hanusch, Folker
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, FINAL_Supplement_2 for Interpretations of the journalistic field: A systematic analysis of how journalism scholarship appropriates Bourdieusian thought by Phoebe Maares and Folker Hanusch in Journalism
title: Regional analysis of Eastern Province feeder road project: district level estimation of the poverty alleviation effects of rural roads improvements in Zambia’s Eastern Province
Creators: name: Kingombe, Christian K.M.
Publisher: name: Graduate Institute of International and Development Studies
publisherIdentifier: https://ror.org/007ygn379
publisherIdentifierScheme: ROR
Year: 2012

description: Graduate Institute of International and Development Studies Working Paper ; no. 10/2012
Conditionally integrable nonlinear diffusion with diffusivity 1/u
Creators: name: Broadbridge, Philip
name: Goard, Joanna M
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 by the authors.
An explicit mapping is given from the space of general complex meromorphic functions to a space of special time-dependent solutions of the 1 + 2-dimensional nonlinear diffusion equation with diffusivity depending on concentration as D=1/u. These solutions have constant-flux boundary conditions. Some simple examples are constructed, including that of a line source enclosed by a cylindrical barrier. This has direct application to electron diffusion in a laser-heated plasma.
Additional file 1 of Overexpression of FoxM1 optimizes the therapeutic effect of bone marrow mesenchymal stem cells on acute respiratory distress syndrome
Creators: name: Luo, Yuling
name: Ge, Shanhui
name: Chen, Qingui
name: Lin, Shan
name: He, Wanmei
name: Zeng, Mian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Original uncropped blots of the text WB figure in the manuscript.
GoSafeOpt: Scalable Safe Exploration for Global Optimization of Dynamical Systems
Creators: name: Sukhija, Bhavya
name: Turchetta, Matteo
name: Lindner, David
name: Krause, Andreas
name: Trimpe, Johann Sebastian
name: Baumann, Dominik Oliver
Publisher: name: RWTH Aachen University
Year: 2022
Subjects: subject: FOS: Computer and information sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: Machine Learning (cs.LG)
subject: Systems and Control (eess.SY)

description: 66 Seiten (2022). doi:10.48550/arXiv.2201.09562
Learning Fast and Precise Pixel-to-Torque Control
Creators: name: Bleher, Steffen
name: Heim, Steve
name: Trimpe, Johann Sebastian
Publisher: name: RWTH Aachen University
Year: 2022
Subjects: subject: FOS: Computer and information sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)

description: 9 Seiten (2022). doi:10.48550/arXiv.2208.02315
appendix.rjf_online_supp – Supplemental material for Envisioning Shared Decision Making: A Reflection for the Next Decade
Creators: name: Barton, Jennifer L.
name: Kunneman, Marleen
name: Hargraves, Ian
name: LeBlanc, Annie
name: Brito, Juan P.
name: Scholl, Isabelle
name: Montori, Victor M.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, appendix.rjf_online_supp for Envisioning Shared Decision Making: A Reflection for the Next Decade by Jennifer L. Barton, Marleen Kunneman, Ian Hargraves, Annie LeBlanc, Juan P. Brito, Isabelle Scholl and Victor M. Montori in MDM Policy & Practice
title: Integration von Flüchtlingen in Deutschland: Erste Ergebnisse der ReGES-Studie
Creators: name: Will, Gisela
name: Balaban, Ebru
name: Dröscher, Anike
name: Homuth, Christoph
name: Welker, Jörg
Publisher: name: LIfBi Leibniz Institute for Educational Trajectories
Year: 2018
Subjects: subject: ReGES
subject: Flüchtlingsstudie
subject: Strukturelle Integration
subject: Kulturelle Integration
subject: Soziale Integration
subject: Emotionale Integration
subject: Refugee study
subject: structural integration
subject: cultural integration
subject: social integration
subject: emotional integration

description: Anhand der Daten der ersten Welle der ReGES-Studie wird mit Hilfe verschiedener Integrationsindikatoren die aktuelle Lebenssituation von Flüchtlingsfamilien in Deutschland dargestellt. Nach einer kurzen Beschreibung des Studiendesigns sowie der Ausschöpfung der ersten Welle werden erste deskriptive Ergebnisse vorgestellt. Die Darstellung orientiert sich an den vier Dimensionen der Sozialintegration: strukturelle, kulturelle, soziale und emotionale Integration.
Die strukturelle Integration der Kinder und Jugendlichen ist schon weit fortgeschritten: Ein Großteil der Kinder mit Fluchthintergrund unter sechs Jahren besucht eine Kindertagesstätte und über die Hälfte der Jugendlichen besucht bereits eine Regelklasse. Somit hat die Mehrheit der Kinder und Jugendlichen Kontakt zur Sprache des Aufnahmelandes und zur Mehrheitsbevölkerung. Dies zeigt sich auch in den Ergebnissen zur sozialen und kulturellen Integration. Ein Großteil der Jugendlichen hat täglich oder mehrmals wöchentlich Kontakt zu Deutschen und die eigene Einschätzung der Deutschkenntnisse ist sowohl bei Kindern als auch bei Jugendlichen bereits sehr positiv. In anderen Bereichen der Gesellschaft (wie etwa dem Arbeitsmarkt) besteht aber noch Nachholbedarf.
Insgesamt sind die befragten Familien mit ihrer Situation in Deutschland eher zufrieden und die Daten zeigen, dass die befragten Flüchtlinge hohe Bildungsambitionen haben und mit großer Mehrheit in Deutschland bleiben wollen.
Sequence Duplication in 3ʹ UTR Modulates Virus Replication and Virulence of Japanese encephalitis virus
Creators: name: Zhang, Qiu-Yan
name: Liu, Si-Qing
name: Li, Xiao-Dan
name: Li, Jia-Qi
name: Zhang, Ya-Nan
name: Deng, Cheng-Lin
name: Zhang, Hong-Lei
name: Li, Xu-Fang
name: Fang, Chun-Xiao
name: Yang, Feng-Xia
name: Zhang, Bo
name: Xu, Yi
name: Ye, Han-Qing
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Japanese encephalitis virus (JEV), an important neurotropic pathogen, belongs to the genus Flavivirus of the family Flaviviridae and has caused huge threat to public health. It is still obscure regarding the functions of stem loop (SL) and dumbbell (DB) domains of JEV 3ʹ UTR in viral replication and virulence. In the current study, using the infectious clone of JEV SA14 strain as a backbone, we constructed a series of deletion mutants of 3ʹ UTR to investigate their effects on virus replication. The results showed that partial deletions within SL or DB domain had no apparent effects on virus replication in both mammalian (BHK-21) and mosquito (C6/36) cells, suggesting that they were not involved in viral host-specific replication. However, the entire SL domain deletion (ΔVR) significantly reduced virus replication in both cell lines, indicating the important role of the complete SL domain in virus replication. The revertant of ΔVR mutant virus was obtained by serial passage in BHK-21 cells that acquired a duplication of DB domain (DB-dup) in the 3ʹ UTR, which greatly restored virus replication as well as the capability to produce the subgenomic flavivirus RNAs (sfRNAs). Interestingly, the DB-dup mutant virus was highly attenuated in C57BL/6 mice despite replicating similar to WT JEV. These findings demonstrate the significant roles of the duplicated structures in 3ʹ UTR in JEV replication and provide a novel strategy for the design of live attenuated vaccine.
Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus serotypes 1-4
Creators: name: Tamura, Tomokazu
name: Zhang, Jiayu
name: Madan, Vrinda
name: Biswas, Abhishek
name: Schwoerer, Michael P.
name: Cafiero, Thomas R.
name: Heller, Brigitte L.
name: Wang, Wei
name: Ploss, Alexander
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Dengue is caused by four genetically distinct viral serotypes, dengue virus (DENV) 1-4. Following transmission by Aedes mosquitoes, DENV can cause a broad spectrum of clinically apparent disease ranging from febrile illness to dengue hemorrhagic fever and dengue shock syndrome. Progress in the understanding of different dengue serotypes and their impacts on specific host-virus interactions has been hampered by the scarcity of tools that adequately reflect their antigenic and genetic diversity. To address this, we created and characterized infectious clones of DENV1-4 originating from South America, Africa, and Southeast Asia. Analysis of whole viral genome sequences of five DENV isolates from each of the four serotypes confirmed their broad genetic and antigenic diversity. Using a modified circular polymerase extension reaction (CPER), we generated de novo viruses from these isolates. The resultant clones replicated robustly in human and insect cells at levels similar to those of the parental strains. To investigate in vivo properties of these genetically diverse isolates, representative viruses from each DENV serotype were administered to NOD Rag1-/-, IL2rgnull Flk2-/- (NRGF) mice, engrafted with components of a human immune system. All DENV strains tested resulted in viremia in humanized mice and induced cellular and IgM immune responses. Collectively, we describe here a workflow for rapidly generating de novo infectious clones of DENV – and conceivably other RNA viruses. The infectious clones described here are a valuable resource for reverse genetic studies and for characterizing host responses to DENV in vitro and in vivo.
Assembly of root-associated microbiomes of typical rice cultivars in response to lindane pollution
Creators: name: Feng, Jiayin
name: Xu, Yan
name: Ma, Bin
name: Tang, Caixian
name: Brookes, Philip C
name: He, Yan
name: Xu, Jianming
Publisher: name: La Trobe
Year: 2021
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3004
subject: Crop and pasture production
classificationCode: 41
subject: Environmental sciences

description: © 2019 The Authors Organochlorine pesticides have been extensively used for many years to prevent insect diseases of rice (Oryza sativa L.), but little is known about their residual impacts on the underground micro-ecology in anaerobic environment. In this glasshouse study, we characterized the lindane effects on the assembly of root-associated microbiomes of commonly used indica, japonica and hybrid rice cultivars, and their feedback in turn, in modifying lindane anaerobic dissipation during 60 days' rice production. The results showed that rice growth inhibited the anaerobic dissipation of lindane, but was not affected apparently by lindane at initial spiked concentration of 4.62 and 18.54 mg kg−1 soil. Suppressed removal of lindane in rice planted treatments as compared with that in unplanted control was likely due to inhibited reductive dechlorination induced by a comprehensive effect of radial O2 secretion of rice root and co-occurring Fe(III) reduction that consumed electron competitively in rice rhizosphere. However, the hybrid cultivar exhibited a less suppression than the conventional cultivars in high polluted soils. Bacteria was more sensitively responded to lindane pollution than fungal taxa, and Actinobacteria, Chloroflexi, Verrucomicrobia and Proteobacteria were the main different phyla between hybrid and conventional cultivars, with a more stable community structure exhibited in the hybrid rice under lindane stress. Our study highlights the assembly and variation of root-associated microbiomes in responses of lindane pollution, and suggests that hybrid rice cultivar might be most competent for cultivation in paddy fields polluted by lindane and other organochlorine pesticides, especially in the area with high residual levels.
Three doses of an inactivation-based COVID-19 vaccine induces cross-neutralizing immunity against the SARS CoV-2 Omicron variant
Creators: name: Yu, Xiaoling
name: Qi, Xiangrong
name: Cao, Yu
name: Li, Peiyao
name: Lu, Li
name: Wang, Pingping
name: Feng, Yuchen
name: Yang, Jie
name: Wei, Huihui
name: Guo, Lixian
name: Sun, Mingyue
name: Liu, Qiang
name: Lv, Jing
name: Feng, Yingmei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The immunity potency upon natural infection or vaccination is the main concern for the vaccine strategy of severe acute respiratory syndrome coronavirus 2（SARS COV-2 variant）, especially the recently reported Omicron variant (B.1.1.529). In this study, 200 recipients immunized with three doses of a COVID-19-inactivated vaccine were enrolled, whose serum samples were collected within 2 months after the third immunization. The neutralizing activity of sera against the pseudotyped Omicron variant, prototype, and Delta variant was determined. Our results demonstrated that the positive neutralization activity was 95.5% for the Omicron variant, 99.5% for the prototype, and 98.5% for the Delta variant. The geometric mean titers （GMT） for the Omicron variant was 49 and maintained sustained immune levels for 2 months, which decreased by 4.9-fold and 3.0-fold compared with the prototype (GMT, 239) and Delta variant (GMT, 148), respectively. In summary, our study demonstrated that three doses of a COVID-19-inactivated vaccine effectively yielded potent cross-neutralizing activity against the Omicron variant at 2 months after the third vaccination.
Composition of soil organic matter drives total loss of dieldrin and dichlorodiphenyltrichloroethane in high-value pastures over thirty years
Creators: name: Krohn, Christian
name: Jin, Jian
name: J Ryan
name: P Fabijański
name: Franks, Ashley
name: Caixian Tang
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 Elsevier
The residues of dieldrin and dichlorodiphenyltrichloroethane (DDT), internationally-banned agricultural insecticides, continue to exceed government guidelines in some surface soils 30 years after use. Little is known regarding the soil factors and microbial community dynamics associated with the in-situ biodegradation of these organochlorine chemicals. We hypothesised that soil organic matter, a key factor affecting microbial biomass and diversity, affects the biodegradation and total loss of the pollutants 30 years after use. We sampled 12 contaminated paddocks with residue concentrations monitoring data since 1988 that represent two different agricultural surface-soils. The total loss and current concentrations of the residues was correlated with soil physicochemical properties, microbial biomass carbon, microbial community diversity indices and microbial community abundance. Current dieldrin and DDT residue concentrations were positively correlated with soil organic matter and clay contents. However, key indicators for loss of residues after 23–30 years were low carbon-to‑nitrogen ratios, high microbial-C-to-total-C ratios and high fungal community evenness. The results support the composition of soil organic matter as an important factor affecting degradation of organochlorines and that co-metabolism of dieldrin and DDT could be enhanced by manipulating the composition of soil organic matter to cater for a broad diversity of microbial function.
Ploughing ahead –  our midyear milestones
Creators: name: Korzek, Kornelia
name: Bartell, Amanda
name: Rittman, Martyn
name: Cousijn, Helena
name: Clark, Rosa
name: Feeney, Patricia
name: Bowman, Sara
Publisher: name: Zenodo
Year: 2025

description: Catch up on our latest Crossref Community Update, recorded on May 7. In this online session, we shared recent developments and answered questions from the community.

Highlights include:

A metadata schema update

New tools and services

The Crossref Metadata Awards

And more
Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Creators: name: Missailidis, Daniel
name: Annesley, Sarah
name: Fisher, Paul
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: The underlying molecular basis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is not well understood. Characterized by chronic, unexplained fatigue, a disabling payback following exertion (“post-exertional malaise”), and variably presenting multi-system symptoms, ME/CFS is a complex disease, which demands a concerted biomedical investigation from disparate fields of expertise. ME/CFS research and patient treatment have been challenged by the lack of diagnostic biomarkers and finding these is a prominent direction of current work. Despite these challenges, modern research demonstrates a tangible biomedical basis for the disorder across many body systems. This evidence is mostly comprised of disturbances to immunological and inflammatory pathways, autonomic and neurological dysfunction, abnormalities in muscle and mitochondrial function, shifts in metabolism, and gut physiology or gut microbiota disturbances. It is possible that these threads are together entangled as parts of an underlying molecular pathology reflecting a far-reaching homeostatic shift. Due to the variability of non-overlapping symptom presentation or precipitating events, such as infection or other bodily stresses, the initiation of body-wide pathological cascades with similar outcomes stemming from different causes may be implicated in the condition. Patient stratification to account for this heterogeneity is therefore one important consideration during exploration of potential diagnostic developments.
Corn-drying kilns in Wales: a review of the evidence.
Creators: name: Burrow, Steve
name: Comeau, Rhiannon
Publisher: name: Archaeology Data Service
Year: 2021

description: Archaeologia Cambrensis, 170, 111-149
description: Corn-drying kilns are becoming increasingly recognised on archaeological sites in Wales, the charred grain and seeds they contain providing valuable evidence of dating, agricultural practices and economic activity. These multi-functional features were used for different stages of crop processing as well as for malting grain for ale-making, and their presence alone, on early sites at least, is suggestive of processes associated with social complexity. This paper examines the form, dating, function and location of recorded Welsh examples dating from later prehistory up to the sixteenth century AD and considers priorities for future research. A gazetteer lists all known examples and is published in conjunction with an online dataset which provides greater detail and is intended to be updated as new information becomes available