cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supplementary document for Experimental observations of bright dissipative Kerr cavity solitons and their collapsed snaking in a driven resonator with normal dispersion - 4759723.pdf
Creators: name: Li, Zongda
name: Xu, Yiqing
name: Coen, Stephane
name: Murdoch, Stuart
name: Erkintalo, Miro
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary document
Performing a comprehensive radio-physical examination of the leksell gamma knife Icon treatment unit
Creators: name: Ponnusamy Natesan
name: Senthil Manikandan Palaniappan
name: Sulthan Asath Bahadur
name: Muthiah Muthuvinayagam
name: Nishanth Sadashiva
name: Nanda Karthick
Publisher: name: Zenodo
Year: 2024

description: The Gamma Knife Icon unit is the latest radiosurgery equipment used for noninvasively treating intra-cranial diseases through Stereotactic radiosurgery treatment procedures. Performing radio-physical testing on the new Gamma Knife Icon unit before starting clinical procedures is essential to ensure its functionality. In line with the manufacturer's recommendations and the American Association of Physicists in Medicine (AAPM) formed Task Group 178 (TG-178), we conducted the vital radio physical tests for the newly installed Gamma Knife unit, including precision of beam alignment, measurement of Gamma Knife accuracy, Center Position measurements, off center position measurements, measurement of absorbed dose rate, and Relative Output factor measurement. We used high special resolution External Beam Therapy 3 (EBT3) GafChromic film and small volume ion chambers (Exradin A16, chamber volume 0.007 cc and PTW 0.125 cc) for the above mentioned tests. We also performed the source confirmation test with a 16 mm collimator. Our results are consistent with previous literature values and within international guidelines' acceptable measurement uncertainty tolerance.
The 'first business of government': The land granting administration of Upper Canada.
Creators: name: Moorman, David T.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: History, Canadian.

description: When the Loyalist refugees fleeing the American revolution in the 1780's arrived in what would become the province of Upper Canada, the colonial government faced a new and unwelcomed situation. Colonial officials in both London and Quebec abandoned their plans for the expansion of the French colony and the preservation of an extensive western Native reservation in favour of a British-style settlement, complete with a balanced constitution, common law, and free and soccage land tenure. The first business faced by this new conservative-minded, loyal government was the distribution of land. In conducting this business the Imperial government, and its officers in Upper Canada, constructed an administration that mixed inherited continuities with innovation. Through the desire for efficiency and accountability, this administration was slowly transformed from a quasi-feudal to a modern bureaucratic system. Many of the decisions and actions of the colonial administrators proved effective and far-sighted, others were much less so. In the end, however, the government was neither corrupt nor incompetent, and, by the 1830's, they succeed in accomplishing the principal goal of land granting; the broad distribution of land to industrious settlers loyal to the British monarchy. The structures through which this was accomplished became the framework of Canada's modern bureaucracy.
Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic pro-inflammatory immune responses following murine Campylobacter jejuni infection
Creators: name: Bereswill, Stefan
name: Ekmekciu, Ira
name: Escher, Ulrike
name: Fiebiger, Ulrike
name: Stingl, Kerstin
name: Heimesaat, Markus M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Infection
subject: Mucosal immunology
subject: Pathogens
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Campylobacter jejuni infections are progressively increasing worldwide. Probiotic treatment might open novel therapeutic or even prophylactic approaches to combat campylobacteriosis. In the present study secondary abiotic mice were generated by broad-spectrum antibiotic treatment and perorally reassociated with a commensal murine Lactobacillus johnsonii strain either 14 days before (i.e. prophylactic regimen) or 7 days after (i.e. therapeutic regimen) peroral C. jejuni strain 81–176 infection. Following peroral reassociation both C. jejuni and L. johnsonii were able to stably colonize the murine intestinal tract. Neither therapeutic nor prophylactic L. johnsonii application, however, could decrease intestinal C. jejuni burdens. Notably, C. jejuni induced colonic apoptosis could be ameliorated by prophylactic L. johnsonii treatment, whereas co-administration of L. johnsonii impacted adaptive (i.e. T and B lymphocytes, regulatory T cells), but not innate (i.e. macrophages and monocytes) immune cell responses in the intestinal tract. Strikingly, C. jejuni induced intestinal, extra-intestinal and systemic secretion of pro-inflammatory mediators (such as IL-6, MCP-1, TNF and nitric oxide) could be alleviated by peroral L. johnsonii challenge. In conclusion, immunomodulatory probiotic species might offer valuable strategies for prophylaxis and/or treatment of C. jejuni induced intestinal, extra- intestinal as well as systemic pro-inflammatory immune responses in vivo.
title: Adenoma pleomorfo de glándulas salivares en imagen.
Creators: name: García Vázquez, Maria del Carmen
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Head and neck
subject: Salivary glands
subject: CT-High Resolution
subject: MR

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Revisar nuestra serie de pacientes con adenoma pleomorfo de glándulas salivares y describir las principales características epidemiológicas y radiológicas (TC y RM) de este tipo de tumores,
sus implicaciones pronósticas,
terapeúticas y...
Supplementary document for Experimental observations of bright dissipative Kerr cavity solitons and their collapsed snaking in a driven resonator with normal dispersion - 4759723.pdf
Creators: name: Li, Zongda
name: Xu, Yiqing
name: Coen, Stephane
name: Murdoch, Stuart
name: Erkintalo, Miro
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplementary document
GalNAc-containing neoglycoconjugates having various geometries and valencies: Syntheses and their lectin binding studies.
Creators: name: Kim, Jin Mi.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Chemistry, Organic.

description: A series of scaffolding glycoconjugates were synthesized with various carbohydrate densities, conformations, and interglycosidic spacers. These compounds include glycopeptoids, glycocalix[4]arenes, self-assembled glycoclusters and glycodendrimers, glyco PAMAM dendrimers, and glycopolymers. The synthesis of Tn-antigen glycopeptidomimetic clusters, peptoids (N-substituted oligoglycines), was accomplished to generate metabolically stable glycopeptide analogs in multivalent fashion. By reiteration of the deprotection-coupling process using monomer and dimer as building blocks, trimer and tetramer were synthesized. Hexamer and octamer were obtained in the same manner. Whereas glycopeptoids are arranged in linear fashion, structurally more defined, tree-like glycodendrimers were synthesized utilizing GaINAc derivatives as carbohydrate entities and calix[4]arene as a core to afford tetra-, octa-, and hexadecamers. Two tetramers, each having four equidistant GaINAc residues, with different lengths of spacer arms were synthesized by coupling GaINAc ligands to acyl chloride on a p-tert-butylcalix[4]arene core. Glycocalix[4]arenes with higher valencies, octa- and hexadecamers were obtained using a double N-alkylation strategy. This strategy was extended to synthesize glyco PAMAM dendrimers. The second generation (G2), StarburstRTM PAMAM core was dialkylated with bromoacetylated GaINAc derivatives to afford 32-mers. A more convenient alternative to long and iterative procedures to construct hyperbranched glycodendrimers evaluated nucleated simple building blocks (dendrons) around metal ions. The synthesis of small building blocks and their non-covalent assembly around the metal ions, Fe(II) and Cu(II) were described. Preparations of enzymetically stable C-glycosides of GaINAc were also presented. O-Acetyl protected galactal was azido-phenylselenylated and Keck allylation at the anomeric center afforded alpha-linked C-glycosides. Elongated C-glycosyl derivatives were used to synthesize small and rigid glycoclusters to investigate the cross-linking properties of Vicia villosa B4 (VVA) lectin. Turbidimetric assays confirmed the ability of the glycodendrimers to cross-link and precipitate the lectin. Solid phase enzyme-linked lectin assay (ELLA) of all the synthesized glycoconjugates showed improved inhibitory efficacy compared to allyl alpha-D-GaINAc which was used as a reference.
Successful lung transplantation in an HIV seropositive patient with desquamative interstitial pneumonia: a case report
Creators: name: Ong, Shaun
name: Levy, Robert D.
name: Yee, John
name: Partovi, Nilu
name: Churg, Andrew
name: Roméo, Philippe
name: Chalaoui, Jean
name: Nador, Roland
name: Wright, Alissa
name: Manganas, Hélène
name: Ryerson, Christopher J.
Publisher: name: BioMed Central
Year: 2018

description: Background: Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the advent of highly active antiretroviral therapies (HAART); however, HIV remains a relative contraindication to lung transplantation. We describe, to our knowledge, the first HIV seropositive lung transplant recipient in Canada. We also review the literature of previously reported cases of solid-organ transplantation in patients with HIV with a focus on immunosuppression considerations. Case presentation: A 48-year old man received a bilateral lung transplant for a diagnosis of desquamative interstitial pneumonia (DIP) attributed to cigarette and cannabis smoking. His control of HIV infection pre-transplant was excellent on HAART, and he had no other contraindications to lung transplantation. The patient underwent bilateral lung transplantation using basiliximab, methylprednisolone, and mycophenolate mofetil (MMF) as induction immunosuppression. He was maintained on MMF, prednisone, and tacrolimus thereafter, and restarted his HAART regimen immediately post-operatively. His post-transplant course was complicated by Grade A1 minimal acute cellular rejection, as well as an enterovirus/rhinovirus graft infection. Despite these complications, his functional status and control of HIV infection remain excellent 24 months post-transplant. Conclusions: Our patient is one of only several HIV seropositive lung transplant recipients reported globally. With growing acceptance of transplantation in this population, there is a need for clarification of prognosis post-transplantation, as well as optimal immunosuppression regimens for these patients. This case report adds to the recent literature that suggests HIV seropositivity should not be considered a contraindication to lung transplantation, and that post-transplant patients with HIV can be managed safely with basiliximab, tacrolimus, MMF and prednisone.
Human peptides α-defensin-1 and -5 inhibit pertussis toxin
Creators: name: Kling, Carolin
name: Pulliainen, Arto T.
name: Barth, Holger
name: Ernst, Katharina
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: pertussis toxin
subject: ADP-ribosylating toxin
subject: bacterial AB-type toxin
subject: human peptide
subject: antimicrobial peptide
subject: toxin inhibitor
subject: DDC 610 / Medicine & health
subject: Pore forming cytotoxic proteins
subject: ADP ribose transferases
subject: Bacterial toxins
subject: Defensins
subject: Bordetella pertussis
subject: Bakteriengift
subject: ADP-Ribosyltransferasen
subject: Defensine

description: Bordetella pertussis causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor. PT is an AB5-type toxin, and consists of the enzymatic A-subunit PTS1 and five B-subunits, which facilitate binding to cells and transport of PTS1 into the cytosol. PTS1 ADP-ribosylates α-subunits of inhibitory G-proteins (Gαi) in the cytosol, which leads to disturbed cAMP signaling. Since PT is crucial for causing severe courses of disease, our aim is to identify new inhibitors against PT, to provide starting points for novel therapeutic approaches. Here, we investigated the effect of human antimicrobial peptides of the defensin family on PT. We demonstrated that PTS1 enzyme activity in vitro was inhibited by α-defensin-1 and -5, but not β-defensin-1. The amount of ADP-ribosylated Gαi was significantly reduced in PT-treated cells, in the presence of α-defensin-1 and -5. Moreover, both α-defensins decreased PT-mediated effects on cAMP signaling in the living cell-based interference in the Gαi-mediated signal transduction (iGIST) assay. Taken together, we identified the human peptides α-defensin-1 and -5 as inhibitors of PT activity, suggesting that these human peptides bear potential for developing novel therapeutic strategies against whooping cough.
title: Lipoma Parostal. Hallazgos radiológicos característicos
Creators: name: Crespo Martínez, Concepción
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: MR
subject: Conventional radiography
subject: Musculoskeletal soft tissue
subject: Musculoskeletal bone

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Mostrar los hallazgos por imagen del lipoma parostal,
un tumor graso,
benigno e infrecuente,
de aspecto radiológico...
Supplementary document for Nanomechanical test of quantum linearity - 4760251.pdf
Creators: name: Forstner, Stefan
name: Zych, Magdalena
name: Basiri-Esfahani, Sahar
name: Khosla, Kiran
name: Bowen, Warwick
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Material
title: Lo que en ecografía parece un carcinoma de tiroides y es un “quiste tiroideo arrugado”
Creators: name: Crespo Martínez, Concepción
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Cysts
subject: Ultrasound
subject: Thyroid / Parathyroids
subject: Head and neck

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Mostrar el aspecto ecográfico sospechoso de malignidad que pueden adquirir los quistes tiroideos cuando desaparece su componente...
The potential for dispersant use as a maritime oil spill response measure in German waters
Creators: name: Grote, Matthias
name: Bernem, Carlo Van
name: Damian, Hans-Peter
name: Böhme, Birgit
Publisher: name: My University
Year: 2018
Subjects: Umweltauswirkung

description: In case of an oil spill, dispersant application represents a response option, which enhances the natural dispersion of oil and thus reduces coating of seabirds and coastal areas. However, as oil is transferred to the water phase, a trade-off of potential harmful effects shifted to other compartments must be performed. This paper summarizes the results of a workshop on the current knowledge on risks and benefits of the use of dispersants with respect to specific conditions encountered at the German sea areas. The German North Sea coast is a sensitive ecosystem characterised by tidal flats, barrier islands and salt marshes. Many prerequisites for a potential integration of dispersants as spill response option are available in Germany, including sensitivity maps and tools for drift modelling of dispersed and undispersed oil. However, open scientific questions remain concerning the persistence of dispersed oil trapped in the sediments and potential health effects. © 2017 The Authors. Published by Elsevier Ltd.
title: Síndrome del atrapamiento de la arteria poplítea.
Creators: name: Esteve Krauel, Pablo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Interventional vascular
subject: Musculoskeletal soft tissue
subject: Arteries / Aorta
subject: Ultrasound-Colour Doppler
subject: CT-Angiography
subject: MR-Angiography
subject: Surgery
subject: Embolism / Thrombosis

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
El síndrome de atrapamiento de la arteria polítea produce claudicación e isquemia en adultos jóvenes. Existe una forma congénita,
asociada a una alteración del desarrollo de la arteria poplítea y del compartimiento músculo-tendinoso de la...
Pressing innovation and entrepreneurship needs in Australian business: what's holding us back?
Creators: name: McMurray, Adela
name: Buckley, Patricia
Publisher: name: Swinburne
Year: 2024

description: This qualitative study explored pressing innovation and entrepreneurship issues as perceived by 34 participants employed at various levels within the Australasian manufacturing and service sectors. The major implication drawn from this research-in-progress was that the majority of business managers and staff, including those with direct responsibility for innovation and entrepreneurship, do not understand the difference between innovation and entrepreneurship and will describe their needs in relation to innovation as identical to their needs in entrepreneurship. The findings reinforce the need to showcase innovation and entrepreneurship, and to co-ordinate what it is; where to find it; how to support it; and how to maintain it, in business settings.
Supplementary document for Nanomechanical test of quantum linearity - 4760251.pdf
Creators: name: Forstner, Stefan
name: Zych, Magdalena
name: Basiri-Esfahani, Sahar
name: Khosla, Kiran
name: Bowen, Warwick
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplemental Material
Establishment of a preclinical ovine screening model for the investigation of bone tissue engineering strategies in cancellous and cortical bone defects
Creators: name: Pobloth, Anne-Marie
name: Johnson, Kenneth A.
name: Schell, Hanna
name: Kolarczik, Nicolai
name: Wulsten, Dag
name: Duda, Georg N.
name: Schmidt-Bleek, Katharina
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Large animal model
subject: Drill hole model
subject: Cortical and cancellous bone defect
subject: regeneration
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background New tissue engineering strategies for bone regeneration need to be investigated in a relevant preclinical large animal model before making the translation into human patients. Therefore, our interdisciplinary group established a simplified large animal screening model for intramembranous bone defect regeneration in cancellous and cortical bone. Methods Related to a well-established model of cancellous drill hole defect regeneration in sheep, both the proximal and distal epimetaphyseal regions of the femur and the humerus were used bilaterally for eight drill hole cancellous defects (Ø 6 mm, 15 mm depth). Several improvements of the surgical procedure and equipment for an easier harvest of samples were invented. For the inclusion of cortical defect regeneration, a total of eight unicortical diaphyseal drill holes (6 mm Ø) were placed in the proximal-lateral and distal-medial parts of the metacarpal (MC) and metatarsal (MT) diaphyseal bone bilaterally. Acting moments within a normal gait cycle in the musculoskeletal lower limb model were compared with the results of the biomechanical in vitro torsion test until failure to ensure a low accidental fracture risk of utilized bones (ANOVA, p
title: RM del suelo pélvico. Estudio dinámico
Creators: name: Herreros Villaraviz, Marta
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Pelvis
subject: MR

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Valorar el papel de la RM en el estudio por imagen del suelo pélvico: Estudiar en qué casos de sospecha de disfunción del suelo pélvico está indicada la realización de una RM. Revisarcómo se realiza el estudio. Describir los hallazgos en RM...
title: Papel de la RM potenciada en difusión en la detección y caracterización de las metástasis hepáticas.
Creators: name: Lozano Rodríguez, Álvaro
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Metastases
subject: MR-Diffusion/Perfusion
subject: Abdomen
subject: Liver

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
La difusión aplicada al estudio hepático tiene relativamente poco tiempo de vida en relación con los estudios de neurorradiología.
Por esto,
se tiene menos experiencia en su uso para estudiar lesiones hepáticas. Nuestro objetivo es revisar el...
title: TC multidetector en la hemorragia digestiva
Creators: name: Arenaza Choperena, Gorka
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Abdomen
subject: CT
subject: Diagnostic procedure
subject: Haemorrhage

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Demostrar la utilidad del TC en el manejo de la hemorragia...
Supplementary document for Discrete dispersion scan setup for measuring few-cycle laser pulses in the mid-infrared - 4761907.pdf
Creators: name: Geib, Nils
name: Hollinger, Richard
name: Haddad, Elissa
name: Herrmann, Paul
name: Légaré, François
name: Pertsch, Thomas
name: Spielmann, Christian
name: Zuerch, Michael
name: Eilenberger, Falk
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Document
Supplementary document for Discrete dispersion scan setup for measuring few-cycle laser pulses in the mid-infrared - 4761907.pdf
Creators: name: Geib, Nils
name: Hollinger, Richard
name: Haddad, Elissa
name: Herrmann, Paul
name: Légaré, François
name: Pertsch, Thomas
name: Spielmann, Christian
name: Zuerch, Michael
name: Eilenberger, Falk
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Supplementary Document
title: Compresión medular secundaria a neurofibromatosis severa.
Creators: name: Lozano Setién, Elena
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Head and neck
subject: Neuroradiology peripheral nerve
subject: MR

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
1.-Repasar la neurofibromatosis-I como entidad patológica. 2.- Recordar los criterios diagnósticos de la Neurofibromatosis- I. 3.- Presentar los principales hallazgos por imagen de esta facomatosis. 4.- Ilustrar un síndrome de compresión medular...
Brotherly love and 'Love's Brother'
Creators: name: McFarlane, Brian
Publisher: name: Swinburne
Year: 2024

description: As the soundtrack swells relentlessly to all-purpose Mediterranean strains, 'Love's Brother' (Jan Sardi, 2004) gives every sign of being not merely set in the 1950s but made then as well. We are back, it is tempting to think, in the world of some big, glutinous Twentieth Century Fox romance for the new CinemaScope screen; the world of, say, 'Three Coins in the Fountain' (Jean Negulesco, 1954). And so, up to a point, we are; though I don't mean by this to write off the film as a throwback dud.
An explorative cross-sectional study examining self-reported health and nutritional status of disadvantaged people using food banks in Germany
Creators: name: Depa, Julia
name: Hilzendegen, Carolin
name: Tinnemann, Peter
name: Stroebele-Benschop, Nanette
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Food bank
subject: Health
subject: Nutrition
subject: Low socioeconomic status
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Even in high-income countries some population groups depend on food banks to support their food intake. We aimed to explore and compare health and nutritional status of food bank clients (Tafel e.V.) in different cities in Germany. Methods In a cross-sectional study, self-reported health and nutritional status of food bank clients living in three cities (Berlin - capital, Ludwigsburg- affluent city, Fulda - small town) which differ in size, available income and poverty rate, were assessed and compared to survey variables of the low socioeconomic status population of national surveys (DEGS and GEDA). Results Across cities, food bank clients (N = 276, response rate of 21.5 %) did not differ in main socio-demographic characteristics (age, nationality, education, professional qualification, household income). Smoking, having at least one chronic illness, estimating their own health status as moderate to poor and low consumption of fruits and vegetables were common characteristics. Comparing selected variables with the low socioeconomic status population of DEGS and GEDA, differences were found for a higher prevalence of diabetes among food bank clients and a worse self- reported health status. Considerably lower fruit consumption and lower hypertension prevalence among female and lower overweight rates among male food bank clients were found. Conclusions Although people using food banks vary in socio-demographic background, no differences for main demographics across the cities were found. In addition, the study suggests that for some health- and nutrition-related variables, national surveys in Germany might underestimate socioeconomic differences.
title: En la mama no todo es lo que parece: revisión radiológica de lesiones simuladoras
Creators: name: Salvador Errasti, Alba
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Breast

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Describir una amplia variedad de lesiones mamarias cuyos hallazgos radiológicos pueden llevar a equivocación. Describir lesiones mamarias malignas con apariencia benigna y lesiones benignas con signos radiológicos que sugieren malignidad....
Supplementary document for 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening - 4762463.pdf
Creators: name: Meena, Gopikrishnan G.
name: Wall, Thomas
name: Stott, Matthew
name: Brown, Olivia
name: Robison, Richard
name: Hawkins, Aaron
name: Schmidt, Holger
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Revised Supplemental Document
Complement after trauma: suturing innate and adaptive immunity
Creators: name: Chakraborty, Shinjini
name: Karasu, Ebru
name: Huber-Lang, Markus
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Complement
subject: T-cells
subject: B-cells
subject: DDC 610 / Medicine & health
subject: Wounds and injuries
subject: Immunity, Innate
subject: Adaptive immunity
subject: T-Lymphocytes
subject: B-Lymphocytes
subject: Trauma
subject: Komplement
subject: T-Lymphozyt
subject: B-Lymphozyt

description: The overpowering effect of trauma on the immune systemis undisputed. Severe trauma is characterized by systemic cytokine generation, activation and dysregulation of systemic inflammatory response complementopathy and coagulopathy, has been immensely instrumental in understanding the underlying mechanisms of the innate immune system during systemic inflammation. The compartmentalized functions of the innate and adaptive immune systems are being gradually recognized as an overlapping, interactive and dynamic system of responsive elements. Nonetheless the current knowledge of the complement cascade and its interaction with adaptive immune response mediators and cells, including T- and B-cells, is limited. In this review, we discuss what is known about the bridging effects of the complement system on the adaptive immune system and which unexplored areas could be crucial in understanding how the complement and adaptive immune systems interact following trauma.
Comparison of software tools for kinetic evaluation of chemical degradation data
Creators: name: Meinecke, Stefan
name: Ranke, Johannes
name: Wöltjen, Janina
Publisher: name: My University
Year: 2018
Subjects: Software
Chemische Zersetzung
Biologischer Abbau

description: Background For evaluating the fate of xenobiotics in the environment, a variety of degradation or environmental metabolism experiments are routinely conducted. The data generated in such experiments are evaluated by optimizing the parameters of kinetic models in a way that the model simulation fits the data. No comparison of the main software tools currently in use has been published to date. This article shows a comparison of numerical results as well as an overall, somewhat subjective comparison based on a scoring system using a set of criteria. The scoring was separately performed for two types of uses. Uses of type I are routine evaluations involving standard kinetic models and up to three metabolites in a single compartment. Evaluations involving non-standard model components, more than three metabolites or more than a single compartment belong to use type II. For use type I, usability is most important, while the flexibility of the model definition is most important for use type II. Results Test datasets were assembled that can be used to compare the numerical results for different software tools. These datasets can also be used to ensure that no unintended or erroneous behaviour is introduced in newer versions. In the comparison of numerical results, good agreement between the parameter estimates was observed for datasets with up to three metabolites. For the now unmaintained reference software DegKinManager/ModelMaker, and for OpenModel which is still under development, user options were identified that should be taken care of in order to obtain results that are as reliable as possible. Based on the scoring system mentioned above, the software tools gmkin, KinGUII and CAKE received the best scores for use type I. Out of the 15 software packages compared with respect to use type II, again gmkin and KinGUII were the first two, followed by the script based tool mkin, which is the technical basis for gmkin, and by OpenModel. Conclusions Based on the evaluation using the system of criteria mentioned above and the comparison of numerical results for the suite of test datasets, the software tools gmkin, KinGUII and CAKE are recommended for use type I, and gmkin and KinGUII for use type II. For users that prefer to work with scripts instead of graphical user interfaces, mkin is recommended. For future software evaluations, it is recommended to include a measure for the total time that a typical user needs for a kinetic evaluation into the scoring scheme. It is the hope of the authors that the publication of test data, source code and overall rankings foster the evolution of useful and reliable software in the field. © The Author(s) 2018
Supplementary document for 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening - 4762463.pdf
Creators: name: Meena, Gopikrishnan G.
name: Wall, Thomas
name: Stott, Matthew
name: Brown, Olivia
name: Robison, Richard
name: Hawkins, Aaron
name: Schmidt, Holger
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Revised Supplemental Document
Understanding key performance indicators through driver measures
Creators: name: Krishnapillai, Alagesan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, System Science.

description: Performance management is a vital part of every organization for its success and long term survival in the current competitive global market place. An organization needs a sound performance management framework to analyze its data to make strategic and tactical decisions. The weaknesses in today's performance management frameworks are linked to their inability to integrate strategy formulation with implementation. In our thesis, we introduce D river Measure Models that can define cause-and-effect relationship between d river measures and Key Performance Indicators (KPIs) for effective performance management and strategic alignment. Driver Measure Models make the performance management more dynamic as the operational activities are linked to strategies. Another contribution of the thesis is the identification of mathematical techniques to quantify relationships between KPIs and driver measures. Thesis makes an effort to show how mathematical techniques can be used for planning and forecasting outcomes while changing strategies. After conducting analysis using the mathematical techniques, organization can arrive at a set of operational tasks associated to driver measures which need to be executed to achieve its optimal result. Finally, we identified the essential set of criteria that a performance management framework needs to address through a literature survey and a gap analysis of existing frameworks. We created an extension to the Balanced Scorecard framework based on Driver Measure Models and support for the management of external factors to address these criteria and compared it to existing frameworks using a case study.
Developing specific molecular biomarkers for thermal stress in salmonids
Creators: name: Akbarzadeh, Arash
name: Günther, Oliver P.
name: Houde, Aimee L.
name: Li, Shaorong
name: Ming, Tobi J.
name: Jeffries, Kenneth M.
name: Hinch, Scott G.
name: Miller, Kristina M.
Publisher: name: BioMed Central
Year: 2018

description: Background: Pacific salmon (Oncorhynchus spp.) serve as good biological indicators of the breadth of climate warming effects on fish because their anadromous life cycle exposes them to environmental challenges in both marine and freshwater environments. Our study sought to mine the extensive functional genomic studies in fishes to identify robust thermally-responsive biomarkers that could monitor molecular physiological signatures of chronic thermal stress in fish using non-lethal sampling of gill tissue. Results: Candidate thermal stress biomarkers for gill tissue were identified using comparisons among microarray datasets produced in the Molecular Genetics Laboratory, Pacific Biological Station, Nanaimo, BC, six external, published microarray studies on chronic and acute temperature stress in salmon, and a comparison of significant genes across published studies in multiple fishes using deep literature mining. Eighty-two microarray features related to 39 unique gene IDs were selected as candidate chronic thermal stress biomarkers. Most of these genes were identified both in the meta-analysis of salmon microarray data and in the literature mining for thermal stress markers in salmonids and other fishes. Quantitative reverse transcription PCR (qRT-PCR) assays for 32 unique genes with good efficiencies across salmon species were developed, and their activity in response to thermally challenged sockeye salmon (O. nerka) and Chinook salmon (O. tshawytscha) (cool, 13–14 °C and warm temperatures 18–19 °C) over 5–7 days was assessed. Eight genes, including two transcripts of each SERPINH1 and HSP90AA1, FKBP10, MAP3K14, SFRS2, and EEF2 showed strong and robust chronic temperature stress response consistently in the discovery analysis and both sockeye and Chinook salmon validation studies. Conclusions: The results of both discovery analysis and gene expression showed that a panel of genes involved in chaperoning and protein rescue, oxidative stress, and protein biosynthesis were differentially activated in gill tissue of Pacific salmon in response to elevated temperatures. While individually, some of these biomarkers may also respond to other stressors or biological processes, when expressed in concert, we argue that a biomarker panel comprised of some or all of these genes could provide a reliable means to specifically detect thermal stress in field-caught salmon.
Dietary Choline Intake: Current State of Knowledge Across the Life Cycle
Creators: name: Wiedeman, Alejandra M.
name: Barr, Susan I.
name: Green, Tim J.
name: Xu, Zhaoming
name: Innis, Sheila M.
name: Kitts, David D.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Choline, an essential dietary nutrient for humans, is required for the synthesis of the neurotransmitter, acetylcholine, the methyl group donor, betaine, and phospholipids; and therefore, choline is involved in a broad range of critical physiological functions across all stages of the life cycle. The current dietary recommendations for choline have been established as Adequate Intakes (AIs) for total choline; however, dietary choline is present in multiple different forms that are both water-soluble (e.g., free choline, phosphocholine, and glycerophosphocholine) and lipid-soluble (e.g., phosphatidylcholine and sphingomyelin). Interestingly, the different dietary choline forms consumed during infancy differ from those in adulthood. This can be explained by the primary food source, where the majority of choline present in human milk is in the water-soluble form, versus lipid-soluble forms for foods consumed later on. This review summarizes the current knowledge on dietary recommendations and assessment methods, and dietary choline intake from food sources across the life cycle.
Supply Chain Management Practices in SMEs of India: Some Managerial Lessons from Large Enterprises
Creators: name: Ullah, Inayat
name: Narain, Rakesh
name: Singh, Amar
Publisher: name: Zenodo
Year: 2015
Subjects: Supply Chain Management
Trust
Buyer Supplier Relationship
Organizational Culture
Outsourcing
Barriers
Benchmarking

description: The objective of this paper is to provide insight into the similarities and dissimilarities of Supply Chain Management (SCM) practices between large enterprises (LE) and smalland-medium enterprises (SME) of India. Survey method is used to gather the responses from Indian organizations. Exploratory factor analysis is performed to reduce the number of variables, and Reliability analysis is performed to check the consistency of the constructs. A set of hypothesis has been formulated and tested using ANOVA. The findings reveal that the selected sectors have similar opinion regarding the business objectives, supply chain objectives, and reasons for choosing outsourcing strategy. Disagreement exists amongst the sectors on factors developing trust between buyers and suppliers, and kind of relationships maintained with suppliers. It is also observed that SMEs face different barriers than the LEs while implementing SCM practices. Also, SMEs have a culturaldifference and adopt different criteria for selecting benchmarking partners vis-a-vis LEs. This paper identifies,and empirically tests the way the LEs and SMEs differ in employing SCM practices. More importantly, this paper is one of the few which explains the importance of SCM implementation in SME’s perspective. This study adds to the existing SCM literature by finding certain interesting results regarding organizational culture, barriers to SCM implementation, and benchmarking practices in SME context.
Occurrence and coupling of heat and ozone events and their relation to mortality rates in Berlin, Germany, between 2000 and 2014
Creators: name: Fenner, Daniel
name: Krug, Alexander
name: Holtmann, Achim
Publisher: name: My University
Year: 2019
Subjects: Hitzewelle
Lufttemperatur
Luftgüte
Ozon
Sterblichkeit
Wechselwirkung
Berlin
Bundesrepublik Deutschland

description: Episodes of hot weather and poor air quality pose significant consequences for public health. In this study, these episodes are addressed by applying the observational data of daily air temperature and ozone concentrations in an event-based risk assessment approach in order to detect individual heat and ozone events, as well as events of their co-occurrence in Berlin, Germany, in the years 2000 to 2014. Various threshold values are explored so as to identify these events and to search for the appropriate regressions between the threshold exceedances and mortality rates. The events are further analyzed in terms of their event-specific mortality rates and their temporal occurrences. The results reveal that at least 40% of all heat events during the study period are accompanied by increased ozone concentrations in Berlin, particularly the most intense and longest heat events. While ozone events alone are only weakly associated with increased mortality rates, elevated ozone concentrations during heat events are found to amplify mortality rates. We conclude that elevated air temperatures during heat events are one major driver for increased mortality rates in Berlin, but simultaneously occurring elevated ozone concentrations act as an additional stressor, leading to an increased risk for the regional population. Quelle: https://www.mdpi.com
In design we trust: design, governmentality, and the tangibility of governance
Creators: name: Tunstall, Elizabeth (Dori)
Publisher: name: Swinburne
Year: 2024

description: This paper explores the implications of how government is made tangible through designed artifacts, communications, experiences, and environments. Framed by Michel Foucault's concept of governmentality, it addresses how trust in just government is at stake when people feel unable to guide their own 'conduct of conduct.' I suggest areas of emerging design research at the intersections of policy design, innovation and design promotion policy, and design standards. These are framed by three assertions: (1) policy is designed and thus open to designing by people, (2) national design policies (formal or informal) should support the role of design in public sector governance, and (3) when design functions as a way of making governance tangible to everyday people, it makes governance open to the participatory redesigns by those people.
Analysis and design of peer-to-peer video on-demand streaming
Creators: name: Lou, Dafu
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, Electronics and Electrical.

description: The problem of video on-demand (VoD) streaming via peer-to-peer (P2P) overlay networks is still challenging. A novel resilient P2P VoD streaming system is proposed in this thesis based on a multi-video-block transport framework with user interactivity supports. The proposed system, namely resilient VoD (rVoD), consists of a distributed encoded video content caching scheme and a transport protocol based on rateless codes. Notions of production and saturation time, naturally arising in this context, are introduced to characterize the dynamics and performance of the P2P streaming system. Quantified in terms of production, the throughput of the presented framework is shown analytically to increase with time in a manner no worse than an exponential function prior to the saturation time. The notions of production and saturation time may also serve as fundamental concepts for the study of quality of service (QoS) for the proposed system. A necessary condition of saturation time and the relationship between production and server stress are derived for an optimal P2P streaming system. We then study the definition of QoS metrics and their tradeoff. A constraint equation of QoS metrics tradeoff is derived, and the numeric results are demonstrated. A simulation system is developed to measure the performance of rVoD in terms of production, saturation time, several QoS metrics, server stress, latency, and overhead. Results of the simulations demonstrate the advantages of the proposed system compared to previous works and confirm our theoretical analysis.
Supplementary document for Parametric study of optical transmission through plasmonic hole arrays modulated by the phase transition of vanadium dioxide - 4763725.pdf
Creators: name: Donev, Eugenii
name: Hart, Francis
name: Nkurunziza, Bertrand
name: Bertschinger, Kevin
name: Zhang, Jinlin
name: Suh, Jae Yong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental material
'Falling out of the rabbit hole': Former long-term prisoners' negotiation of release, reentry and resettlement
Creators: name: Munn, S. Melissa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Sociology, Criminology and Penology.

description: In criminological literature a great deal of attention has been given to prisons and to recidivism but there is a dearth of scholarly work which examines successful post-prison resettlement, particularly of those who have served long periods of incarceration. In this ethnomethodological study, 20 Canadian men who had served over a decade in prison and been released at least 5 years earlier participated in semi-structured interviews. They describe their experiences preparing to exit the prison, their time on parole and the challenges and strategies that they employ to succeed in the their post-carceral lives. Struggle was a prominent theme as the respondents negotiated changing regulatory contexts, were subject to the panoptic gaze and experienced the psychological trauma resulting from their extensive incarceration. These former prisoners dealt with the challenges of finding work as older men with interrupted (or limited) work histories and navigating ever-changing gender roles after years in an almost exclusively male environment. Using a theoretical approach which weaves together symbolic interactionism, governmentality and critical human geography, this research focuses on former long-term prisoners' sense of place, identity and resistance. For this vantage point, it is evident that the spaces inhabited by the men are not just backdrops to their existence but are fully entangled in their experiences. Considering place rather than just space allows the mens experiences with freedom, disaffiliation, vulnerability and security to be examined in a textured and nuanced way not typically found in criminology. Further, the men's experiences with self and public identity are complex and complicated by both their anticipation of stigma and that which they actually experienced. Through their stories it is clear that, despite their struggles, the men were not passive entities upon which power acted but rather, were able to exert agency within relations of power. The findings of this research suggest directions for policy and practice within the penal justice apparatus.