cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of glycan nature on structure and viscoelastic properties of glycopeptide hydrogels
Creators: name: Proksch, Jonas
name: Dal Colle, Marlene C. S.
name: Heinz, Frederick
name: Schmidt, Robert F.
name: Gottwald, Jacqueline
name: Delbianco, Martina
name: Keller, Bettina G.
name: Gradzielski, Michael
name: Alexiev, Ulrike
name: Koksch, Beate
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: glycopeptide library
subject: mucus
subject: peptide hydrogels
subject: peptide self-assembly
subject: rheology
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Mucus is a complex biological hydrogel that acts as a barrier for almost everything entering or exiting the body. It is therefore of emerging interest for biomedical and pharmaceutical applications. Besides water, the most abundant components are the large and densely glycosylated mucins, glycoproteins of up to 20 MDa and carbohydrate content of up to 80 wt%. Here, we designed and explored a library of glycosylated peptides to deconstruct the complexity of mucus. Using the well-characterized hFF03 coiled-coil system as a hydrogel-forming peptide scaffold, we systematically probed the contribution of single glycans to the secondary structure as well as the formation and viscoelastic properties of the resulting hydrogels. We show that glycan-decoration does not affect α-helix and coiled-coil formation while it alters gel stiffness. By using oscillatory macrorheology, dynamic light scattering microrheology, and fluorescence lifetime-based nanorheology, we characterized the glycopeptide materials over several length scales. Molecular simulations revealed that the glycosylated linker may extend into the solvent, but more frequently interacts with the peptide, thereby likely modifying the stability of the self-assembled fibers. This systematic study highlights the interplay between glycan structure and hydrogel properties and may guide the development of synthetic mucus mimetics.
title: Newspaper Column: The Kain Mutiny
Creators: name: Nicoson, William J.
Publisher: name: The Connection
Year: 1998
Subjects: subject: Kain, George
subject: Reston (VA) Citizens Association (RCA)

description: PDF file distilled from original WordPerfect document. Original size 11" x 8.5".
description: For poor George Kain it’s been out of the frying pan, into the fire, as his commitment to community service moved him from Treasurer of Reston Association to President of Reston Citizens Association. At RA Kain reported monthly to the Board of Directors on such matters as investment of RA reserve funds. On his watch, the Chief Financial Officer on the RA staff steered funds into highrisk debt obligations in violation of RA’s investment policy but, in monthly reports prepared for Kain to deliver to the Board, portrayed these investments falsely as consistent with RA policy. At one point Kain volunteered to perform an internal audit which would surely have exposed the CFO’s fraud, but a majority of the Board, including then-President Cynthia Warger, voted against the audit as constituting “micro-management”. Almost a year later, the fraud was exposed by outside auditors, causing a furor in the community and the firing of the CFO.
Improving The Oral Health Care Capacity Of Federally Qualified Health Centers
Creators: name: Pourat, Nadereh
name: Lampron, Colleen
name: Crall, James J
name: Scoville, Richard
name: Inkelas, Moira
Publisher: name: Health Affairs
Year: 2016

description: Despite efforts that increased dental visits at federally qualified health centers (FQHCs) by 65 percent between 2007 and 2014, only 21 percent of FQHC patients received dental services in 2015-not altogether surprising, given that most such facilities do not offer dental services on site. Many of these facilities are part of multisite organizations that offer dental services at other locations; however, sites with co-located dental and medical services often serve only a fraction of their primary care patients. This article describes an initiative, funded by First 5 LA and led by the University of California, Los Angeles (UCLA), designed to improve access to and quality of oral health care for young children at twenty Los Angeles County FQHCs with co-located medical and dental services. The UCLA-First 5 LA Oral Health Program supported infrastructure enhancements, technical assistance, clinical training, quality improvement, health education for parents and caregivers, and related policy analyses. Findings demonstrate a twofold increase in diagnostic and treatment services capacity for young children and a threefold increase in preventive services capacity after two years. Investments in infrastructure, plus support for training and quality improvement focused on medical and dental integration, were crucial to these capacity increases.
Agricultura de Conservação para a conservação da água e eficiência dos nutrientes
Creators: name: Basch, Gottlieb
Publisher: name: Zenodo
Year: 2022
Subjects: SolACEPA

description: Problema: A agricultura baseada na mobilização intensiva do solo é uma das principais causas da degradação do solo, levando ao escoamento superficial, erosão do solo, declínio da matéria orgânica do solo e compactação. Práticas de gestão do solo precisam de mudar para assegurar uma utilização mais sustentável e eficiente dos recursos. Solução: A Agricultura de Conservação (AC) baseiase em práticas que minimizam a perturbação do solo através da sementeira direta, mantêm uma cobertura permanente do solo com resíduos orgânicos, e utilizam uma gama diversificada de espécies de culturas para, em última análise, melhorar tanto a conservação da água como a eficiência dos nutrientes nos solos agrícolas.
THE ROLE OF PROVERBS AND IDIOMS IN THE ENGLISH LANGUAGE LEARNING
Creators: name: Obruyeva Gulchekhra Khamrokulovna professor of the department of "English language" Samarkand State Institute of Foreign Languages
Publisher: name: Zenodo
Year: 2025

description: This article is dedicated to the study of proverbs and idioms in English language.  We can't imagine an origin of proverbs and idioms without their history. By origin of proverbs and sayings, we can compare culture, social or ethical problems of other people and linguistic features of language too. Proverbs and idioms in language are considered as wealth and decoration of the speech. Especially proverbs reflect culture and a way of life of this or that language, they help to make the speech more expressive and colourful.

           Keywords: phrаseology, idiomаticity, sаyings, proverbs, linguistic, culture,

language, collocation, traditions, habits, superstitions
AVALIAÇÃO DO IMPACTO DA INTELIGÊNCIA ARTIFICIAL NA ENGENHARIA DESAFIOS E OPORTUNIDADES PARA ENGENHEIROS NA ERA DA INTELIGÊNCIA ARTIFICIAL
Creators: name: Matos, Ludymille Santos
name: Ribeiro, Kilder Leite
name: Sisnando, Anderson Dourado
Publisher: name: Zenodo
Year: 2025
Subjects: Inteligência Artificial
Engenharia
Aprendizado de Máquina
Deep Learning
IA Generativa

description: A Inteligência Artificial (IA) está transformando a profissão de engenheiro, impactando as dinâmicas de trabalho, as competências exigidas e os processos de tomada de decisão. Este artigo explora os principais avanços da IA, com foco nas tecnologias de Aprendizado de Máquina (Machine Learning), Aprendizagem Profunda (Deep Learning) e IA Generativa, como o ChatGPT e o DALL-E. Através de uma revisão bibliográfica, foram analisados os desafios e as oportunidades que a IA proporciona aos engenheiros, destacando a automação de tarefas, a otimização de processos e as implicações éticas envolvidas. Conclui-se que, embora a IA traga avanços significativos, é fundamental que os engenheiros continuem a aprimorar suas habilidades e adotem uma abordagem ética e responsável na implementação dessas tecnologias. A integração da IA no cotidiano da engenharia oferece não só soluções inovadoras, mas também impõe a necessidade de adaptação contínua dos profissionais a um ambiente de trabalho em rápida transformação.
title: SYSTEM ANALYSIS AND CONTROL SECTION
title: Determining Anomalous Behavior Of Entities In Large IT Structures
titleType: Subtitle
Creators: name: Hritskevych, Anatolii
Publisher: name: National University "Zaporizhzhia polytechnic"
Year: 2025
Subjects: cybersecurity
SIEM
UAM
log analysis
IT infrastructure
access control

description: Determining Anomalous Behavior Of Entities In Large IT StructuresAs IT systems scale rapidly, cybersecurity gaps often emerge — especially in structures built by different teams without a unified security approach. Our research proposes a combined method for detecting suspicious user activity by integrating OS-level triggers, UAM (User Activity Monitoring) agents, and centralized SIEM log analysis. This layered model enables early threat detection, even before full security systems are deployed. By correlating logs from Linux/Windows tools, real-time triggers, and dashboards in Kibana, we detect both overt and hidden anomalies in user behavior. The system is scalable, flexible, and can be further enhanced with AI for automated analysis and prediction. Developed under the TELEMETRY project (Horizon Europe), this solution helps organizations react faster and smarter to security threats.
Pioneer identification of fake tiger claws using morphometric and DNA based analysis in wildlife forensics in India
Creators: name: Vipin Sharma
name: Sharma, Vinita
name: CP Sharma
name: Joshi, Hemant
name: SP Goyal
Publisher: name: F1000Research
Year: 2016

description: Illegal wildlife trade is a serious threat for the existence of wild animals throughout the world. The short supply and high demand of wildlife articles causes the influx of many different forms of fake wildlife articles in this illegal trade. The task of identifying such type of materials are more challenging in wildlife forensics, as it requires different approaches for species identification. Among a variety of illegal animal parts received at the Wildlife Institute of India (WII), Dehradun for the species identification under wildlife offences, the claws constitutes 3.8% of total (n=2899). Here we describe the identification of seized suspected tiger claws (n=18) using a combined approach of morphometry and DNA based analysis. The presence of differential keratin density determined using x-ray radiographs revealed that all these 18 claws were not of any larger cat but fake.

We used three measurements of claws viz. ac (length from external coronary dermo-epidermal interface to epidermis of skin fold connecting palmer flanges of coronary horn and bc (length from claw tip to epidermis of skin fold connecting palmer flanges of coronary horn) and ratio of bc/ac for all seized (n=18), tiger (n=23) and leopard (n=49) claws. The scatter plot of canonical discriminant functions analysis of seized, tiger and leopard claws reveals that of the 18 seized claws, 14 claws formed a separate cluster from the clusters of tiger and leopard claws, whereas 4 claws were within the cluster of leopard. Due to the observed discrepancy in ‘x’-ray and measurements of these four claws, one of the claws clustered with leopard claws was chosen randomly for DNA analysis using cyt b (150 bp) and 16S rRNA (550 bp) genes. Sequence based analysis using BLAST search and comparison with reference data base at WII indicated that the keratin material used in the claw is of Bos taurus (Cattle). Hence, first time, we report that the fake claws are made from keratin body parts of Bos taurus. We suggest the use of hierarchical based combination of techniques for identifying claws in wildlife offences i.e. ‘x’-ray, morphometric and DNA based analysis to ascertain whether claws are of tiger or leopard. Hence, there is a need to develop the reference database for the species reported in the trade, using morphological features as well as DNA profile for better implementation of Wildlife (Protection) Act, 1972 of India.
Testing long-watch counts as a surrogate for density estimates to monitor parrot populations
Creators: name: Marolla, Filippo
name: Marsden, Stuart J.
name: Boitani, Luigi
name: Valle, Simon
Publisher: name: F1000Research
Year: 2016

description: Estimates of population size are a fundamental basis for any conservation plan. As the number of threatened species is increasing in all natural ecosystems and resources available for their conservation are limited, there is a need for practical, rapid and inexpensive methods to provide reliable metrics of animal population size and trends in abundance. Parrots are among the world’s most threatened orders of birds, and they are difficult to survey accurately. Today, distance sampling is the most reliable method for parrot abundance estimation; however, it is time-consuming and resource-demanding, thus often unfeasible where required resources
and skills are lacking. We explored the efficacy of a simple method to assess parrots abundance, using Grey Parrot Psittacus erithacus as model species. Specifically, we compared local density estimates for Grey Parrot in the island of Príncipe (Gulf of Guinea) calculated by distance sampling, and the number of parrots recorded during long watches counts from vantage points overlooking forest in the same areas. We counted parrots seen flying in, out and over the surveyed areas during four different three-hour time slots, to account for variation in detectability at different times. We used linear mixed effects models to explore the relationship between the two methods.

We found a significant correlation between local densities and the number of outbound flights recorded (i.e. parrots flying outward the surveyed area) for observations made in the last three hours of the day (i.e. 3PM – 6PM). This time slot corresponds to the activity peak of grey parrots in Príncipe at dusk. However, no relationship was found between local densities and the number of outbound, inbound or total flights in all the other time slots. These results suggest that flight frequencies themselves, as counted from vantage points, are not a reliable representation of local densities as calculated from distance sampling surveys. The correlation
we found with outbound flights between 3PM and 6PM is likely to be affected by the high number of individuals travelling through the area to the roosting sites. We  conclude that the use of long watches as an index of abundance is not recommendable if the relationship with actual local abundance has not been tested. However, long watches counts might provide a broad indication of abundance where no other option is available.
Understanding human-tiger conflict – a case study from Corbett Tiger Reserve India
Creators: name: Vipin Sharma
Publisher: name: F1000Research
Year: 2016

description: Human–tiger conflicts have been a major issue in the Terai-Arc Landscape (TAL), in northern India, ever since human settled in the region. For managing such issues, authorities are compelled to eliminate/relocate tigers whenever there is recurrent killing of human beings. But identifying the individual tiger/tigress, involved in conflicts has remained a challenge for wildlife manager as misidentification may lead to the elimination of the wrong individual that do not mitigate the conflict at all. In the present study, we demonstrate the utility of molecular tools by using whatever pre-operational evidences could be collected from a tiger that was eventually killed as a man-eater through a case study from the TAL. In this instance, a tiger attacked and killed four human in different incidents over a period of 3 months (November–December 2010 and January 2011) in and around Corbett Tiger Reserve (CTR), India. The tiger was finally eliminated because it was declared as man eater. Intensive collection of biological samples during conflict period was not done, hence, only a few samples were collected. These were collected from attack sites where the tiger was wounded (n=2) and the site where it was killed (n=2). For each of the sample, we could determine the species, sex and individual identity of the animal involved using molecular markers, i.e. mitochondrial, sex and microsatellite. We found that all the samples came from a male tiger and that it was the same individual that had been involved in the attacks, been wounded and shot dead. We suggest that biological samples, such as hair that had been shed and scats be collected intensively from resting places and blood stains across conflict zones. We also suggest that the genetic identity of the tigers in Uttarakhand be established and so as this information may be used to establish a link with individuals involved in conflicts so that effective strategies may be developed to manage human–wildlife conflicts in TAL corridors, where such conflicts are relatively more frequent.
Responsivity and relation to depressive symptoms of occupational behavior and experience patterns
Creators: name: Papst, Lilia
name: Zickwolf, Christian
name: Käfer, Michael
name: Beierlein, Volker
name: Köllner, Volker
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: depression
subject: burnout
subject: psychological
subject: occupational health
subject: occupational stress
subject: working style
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Work stress is a frequent factor in the development of depression. However, not only workplace environment, but also personal attitudes may affect stress experience. The aim of this study was to investigate the change sensitivity of occupational attitudes in psychosomatic inpatients and assess the relationship of changes to depressive symptom reduction. Methods: The data set encompassed N = 1708 inpatients from two German psychosomatic rehabilitation clinics at admission and discharge. Responsivity of AVEM measures was evaluated by Bonferroni-corrected t-tests and Cohen's dz effect sizes for paired samples. The relation of occupational behavior and experience patterns and depressive symptoms as assessed by the BDI-II questionnaire was calculated by Pearson correlation analysis of pre-post differential values. Results: Changes in work attitudes were found on eight out of eleven AVEM subscales (Padj <= 0.001, Cohen's dz = -0.45 to 0.43) and all AVEM coping styles. Most patients (57.4%) were classified to have a Burnout occupational coping style at admission. Changes following rehabilitation were most frequently observed from Burnout to Sparing coping styles (8.3%). Small to moderate associations between changes in occupational attitudes and depressive symptom reduction were found for all subscales (r = -0.39 to 0.25) except work ambition, and for occupational coping styles Burnout (r = 0.19), Sparing (r = -0.18) and Healthy (r = -0.10), but not Ambitious. Discussion: The data support responsivity of occupational behavior and experience patterns within a psychosomatic rehabilitation setting. Correlations with depressive symptom reduction suggest that occupational attitudes are related but separate treatment targets.
How Context Matters: A Dissemination and Implementation Primer for Global Oncologists
Creators: name: Ramanadhan, Shoba
name: Ginossar, Tamar
name: Nodora, Jesse
name: Zullig, Leah L.
name: Brownson, Ross C.
name: Birken, Sarah A.
name: Kerner, Jon
name: Koczwara, Bogda
name: Cragun, Deborah
name: Chawla, Neetu
name: Perry, Cynthia K.
Publisher: name: American Society of Clinical Oncology (ASCO)
Year: 2016

description: The need for a journal of global oncology reflects a
growing realization by the oncology community
that although evidence behind cancer control
strategies may not differ around the globe, the
context in which this evidence is applied varies
according to available resources, societal values
andpriorities, policies, andhealth care systems.1,2
Context has profound influence on whether and
how evidence is disseminated, adopted, tailored,
and used in clinical practice. Context varies across
countries, cultures, and geographic regions and
reflects the great diversity of people affected by
cancer. Recognition of and work within these diverse
contexts may seem daunting, but the ability
to identify and address the context within whichwe
as clinicians and researchers practice is increasingly
recognized as critical to making a lasting
impact. The emerging field that explores how to
apply evidence in different contexts often is
called dissemination and implementation (D&I)
science.3 Synonyms include knowledge translation,
translational research, and implementation
science.
Innovation in products, processes and marketing to introduce local  woods with special, greater value-added characteristics to the  Catalan market
Creators: name: Colell, Aitor
Publisher: name: Zenodo
Year: 2025
Subjects: Catalonian Wood
Value-Added forestry
Niche market and Sustainable processing

description: The project aims to add value to unique wood types from Catalonian forests by innovating processing, marketing, and distribution. Through the ""SingularWood"" initiative, it offers minimally processed, high-quality wood for craftsmen, enhancing market value and supporting local forestry.
The future is not what it used to be: the failure of bipolarisation
Creators: name: Enyedi, Zsolt
name: Bértoa, Fernando Casal
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Arguably, the most fundamental question one can ask about a party system is whether it is bipolar or not. Based on theoretical conjectures and on tendencies one observed during the 1990s and early 2000s, as well as reflecting the position of the academic community at the time (e.g. [Bale, T. (2003). Cinderella and Her ugly sisters: The mainstream and extreme right in Europe's bipolarising party systems. West European Politics, 26(3), 67–90; Müller, W., & Fallend, F. (2004). Changing patterns of party competition in Austria: From multipolar to bipolar system. West European Politics, 27(5), 801–835]), Peter Mair had a clear prediction: the future of party politics would be bipolar. Using the Who Governs Europe dataset [Casal Bértoa, F., & Enyedi, Z. (2021a). Party system closure: Party alliances, government alternatives, and democracy in Europe. Oxford: Oxford University Press], the article examines the validity of Mair's predictions. Notwithstanding certain exceptions (e.g. Bulgaria, Luxembourg, Serbia), the article demonstrates that the tendency towards increasingly bipolarised party politics has failed to materialise. Next to the description of empirical patterns the article provides suggestions on how to improve our conceptual apparatus of party system analysis.
Supplementary document for Reducing the refractive index by replacing [AlPO4]0 unit with [BPO4]0 in fused silica - 6323503.pdf
Creators: name: guangbiao, xiang
name: jiangbin, zhang
name: zhongyang, xing
name: Huang, Liangjin
name: Pan, Zhiyong
name: zhang, hanwei
name: Wang, Xiaolin
name: weihong, hua
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
title: Alliance Politics in Unipolarity
Creators: name: Sanders, Marietta E.
Publisher: name: George Mason University
Year: 2008
Subjects: subject: Missile defense
subject: Alliance politics
subject: Unipolarity
subject: Alliance

description: Throughout the Cold War the United States relationship with its allies was primarily based on its ability to defend them against the Soviet Union. The US would bear the military burden for their safety in exchange for their support and special economic relationships that would allow the US to continue to prosper and pay for the expense of the military burden. After the Cold War ended these relationships continued to exist, but under different international pressures. The US needs allied involvement in order to build a more robust and complex international missile defense system designed to counter any nation or group seeking to use ballistic missiles against the US or its friends and allies. However, some US allies differ on the need for this type of protection and the attention it brings to them as a close ally of the United States. States may feel the threat has not yet materialized for this type of system, that building this system only further instigates arms races and leads to greater instability, or cooperation with the US on this system will make them more of a target to terrorist organizations or states hostile to American interests. This dynamic has brought out interesting reactions among the US allies on its pursuit of a robust missile defense system. This paper seeks to develop and test a theory that explores the patterns of alliance behavior in a unipolar system and use the issue of missile defense between the United States and its European allies as a case study. This new theory is a combination of components of Glenn H. Snyders and Stephen M. Walts theory of alliances under assumptions of William Wohlforths observations about unipolarity. With this mid-range theory I will seek to better explain the dynamics of the relationships between the United States and European allies through the issue of missile defense in the current international system structure. Additionally, this theory will attempt to determine the most important causal factor behind states decisions within an alliance; whether autonomy or perceptions of threat are a bigger influence in state decisions on security.
The burden of myasthenia gravis – highlighting the impact on family planning and the role of social support
Creators: name: Stein, Maike
name: Grittner, Ulrike
name: Stegherr, Regina
name: Gerischer, Lea
name: Stascheit, Frauke
name: Hoffmann, Sarah
name: Herdick, Meret
name: Legg, David
name: Marbin, Derin
name: Meisel, Andreas
name: Lehnerer, Sophie
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: myasthenia gravis
subject: myasthenia
subject: social support
subject: family planning
subject: pregnancy
subject: miscarriage
subject: burden of disease
subject: caregiver
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Myasthenia gravis (MG) is a rare autoimmune disease and chronic condition that necessitates specialized care. Patients experience a significant burden of disease affecting various aspects of their lives. The aim of this study was to investigate the impact of MG on family planning, challenges associated with pregnancy, childcare responsibilities and the extent to which MG patients perceive and utilize social support. Methods: This analysis used data from our main data of a large cross-sectional study built on a questionnaire-based survey encompassing 1,660 MG patients and members of the German Myasthenia Association (Deutsche Myasthenie Gesellschaft), and focused on sociodemographic, clinical and family planning relevant data points. Results: Decisions regarding family planning were significantly impacted for individuals with MG when MG symptoms started either before or during their family planning (men: n = 19 and 29.7%; women: n = 156 and 58.4%). In this subgroup a substantial proportion opted against parenthood due to MG (men: n = 8 and 50.0%; women: n = 54 and 38.0% and/or another n = 12 and 8.4% of female participants encountered partner-related refusals). In the subgroup of female SP with MG starting before or during family planning who have reported ever been pregnant the self-reported miscarriage rate was 29.0% (n = 51). MG patients with medium incomes or moderate disease severity reported lower levels of perceived social support. 42.7% (n = 606) of participants needed assistance in negotiations with health insurers and 28.0% (n = 459) needed support for transportation to medical appointments. Conclusion: This study shows a significant impact of MG on family planning decisions, affecting both women and men, and often resulting in life-altering decisions such as voluntary childlessness due to MG. The significance of social support becomes evident as a vital factor, especially when navigating through the healthcare system. Tailored healthcare approaches, organized guidance and comprehensive support is needed to enable informed decision-making and offer assistance for MG patients. Clinical trial registration: https://clinicaltrials.gov/study/NCT03979521, Registered 7 June 2019 (retrospectively registered).
Periodontal therapy and glycaemic control among individuals with type 2 diabetes: reflections from the PerioCardio study
Creators: name: Skilton,
name: O'Dea, K
name: Slade, GD
name: Mejia, G
name: Kapellas, K
name: Bartold, PM
name: Brown, A
name: Jamieson, LM
name: Maple‐Brown, LJ
name: Celermajer, DS
Publisher: name: Wiley
Year: 2016

description: OBJECTIVES: Diabetes mellitus and periodontal disease are highly prevalent among Indigenous Australian adults. Untreated periodontitis impacts glycaemic control in people with diabetes. The aim of this study was to report on the effect of periodontal therapy on glycaemic control among people with obesity.
METHODS: This subgroup analysis is limited to 62 participants with diabetes from the original 273 Aboriginal Australian adults enrolled into the PerioCardio study. Intervention participants received full-mouth non-surgical periodontal scaling during a single, untimed session while controls were untreated. Endpoints of interest included change in glycated haemoglobin (HbA1c), C-reactive protein (CRP) and periodontal status at 3 months post-intervention.
RESULTS: There were more females randomized to the treatment group (n = 17) than control (n = 10) while the control group had a higher overall body mass index (BMI) [mean (SD)] 33.1 (9.7 kg m-2) versus 29.9 (6.0 kg m-2). A greater proportion of males were followed up at 3 months compared to females, P = 0.05. Periodontal therapy did not significantly reduce HbA1c: ancova difference in means 0.22 mmol mol-1 (95% CI -6.25 to 6.69), CRP: ancova difference in means 0.64 (95% CI -1.08, 2.37) or periodontal status at 3 months.
CONCLUSIONS: Non-surgical periodontal therapy did not significantly reduce glycated haemoglobin in participants with type 2 diabetes. Reasons are likely to be multifactorial and may be influenced by persistent periodontal inflammation at the follow-up appointments. Alternatively, the BMI of study participants may impact glycaemic control via alternative mechanisms involving the interplay between inflammation and adiposity meaning HbA1c may not be amenable to periodontal therapy in these individuals.
The impact of nontransparent health communication during the COVID-19 pandemic on vaccine-hesitant people’s perception of vaccines
Creators: name: Wegwarth, Odette
name: Hertwig, Ralph
name: Giese, Helge
name: Fineberg, Harvey V.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2024
Subjects: subject: risk communication
subject: public health communication
subject: COVID-19 vaccine
subject: vaccine hesitancy
subject: evidence-based health communication
subject: health literacy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Although transparency is crucial for building public trust, public health communication during the COVID-19 pandemic was often nontransparent. Methods: In a cross-sectional online study with COVID-19 vaccine-hesitant German residents (N = 763), we explored the impact of COVID-19 public health communication on the attitudes of vaccine-hesitant individuals toward vaccines as well as their perceptions of incomprehensible and incomplete information. We also investigated whether specific formats of public health messaging were perceived as more trustworthy. Results: Of the 763 participants, 90 (11.8%) said they had become more open-minded toward vaccines in general, 408 (53.5%) reported no change, and 265 (34.7%) said they had become more skeptical as a result of public health communication on COVID-19 vaccines. These subgroups differed in how incomprehensible they found public health communication and whether they thought information had been missing. Participants' ranking of trustworthy public health messaging did not provide clear-cut results: the fully transparent message, which reported the benefit and harms in terms of absolute risk, and the nontransparent message, which reported only the benefit in terms of relative risk were both considered equally trustworthy (p = 0.848). Discussion: Increased skepticism about vaccines during the COVID-19 pandemic may have partly been fueled by subpar public health communication. Given the importance of public trust for coping with future health crises, public health communicators should ensure that their messaging is clear and transparent.
Dynamically genetic program by co-regulated TF groups during the pressure overload-induced cardiac hypertrophy in mice
Creators: name: Chang, Yao-Ming
name: Shih, Arthur Chun-Cheih
name: Li, Ling
name: Chang, Ya-Ting
name: Chien-Chang Chen
Publisher: name: F1000Research
Year: 2016

description: Many heart diseases, such as hypertension, heart failure, and valvular heart disease, are accompanied by the cardiac hypertrophy. Understanding comprehensively what transcription factors (TFs) induce the hypertrophic process and when this process begins after pressure overload will be important in providing potential therapeutic targets in treating cardiovascular diseases. In this study, we collected the whole transcriptome data, including gene and miRNA expression data, isolated from hypertrophic murine hearts subjected to transverse aorta banding surgery (TAB) and without TAB surgery (sham) at five time points among the four weeks, respectively. From three analytical perspectives, we analyzed the whole transcriptome differences, functional distributions of differentially expressed genes, and clustered transcription factor (TF) coexpression network. In the result, we found that the globally genetic change began in the early stage, after cardiac pressure-overloaded, earlier than morphological change; moreover, the globally genetic change returned to a normal level within few days while the cardiac size kept on enlarging. It reveals the inconsistent timing between genetic and morphological changes. In addition, we also identified quite a few of TFs and miRNAs that differentially expressed in different stages and many of them have been also found in literature. Interesting, some miRNAs, verified with cardiac functions previously, were expressed not in the early stage but in dozens of days after TAB that indicates their suppression role in the hypertrophic process. In short, using and analyzing a time course transcriptome data our results can enhance the understanding in the dynamically genetic regulation in cardiac hypertrophy.
Party conflict regulation and intra-party hierarchy in contemporary party organization
Creators: name: Bolleyer, Nicole
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Developmental Biology
subject: Science Policy

description: This paper is concerned with one important dimension of intra-organizational hierarchy that has to date received only little attention in cross-national party research, although its relevance has grown in light of both the increasing empowerment of rank-and-file members and the growing inclusiveness of contemporary party organizations: the range of monitoring and disciplinary mechanisms available to parties to manage internal differences and dissent essential to assure the day-to-day functioning of complex organizations. Based on the distinction between ‘organizational control’ and ‘leadership power’ that can be exercised through these mechanisms, this paper explores how the availability and nature of such mechanisms in party statutes is shaped by differences in ideology on the party level and the legal regulation of intra-party conflict regulation on the system level. Patterns are examined with regard to state-wide parties in Germany and Spain, two countries that regulate intra-party conflict legally, and the UK and Ireland, two countries that do not.
title: Welch's tourist court
Creators: name: (:Unkn) Unknown
Publisher: name: George Mason University
Year: 2006
Subjects: subject: Fairfax (Va.)--Pictorial works
subject: Postcards--Virginia--Fairfax
subject: Motels--Virginia--Fairfax

description: Text on front: Welch's tourist court ; Fairfax, VA.
description: Text on back: Staying at "Hub Welch's tourist court" ; yes, the cabins are steam heated and equipped with all modern conveniences, and only 17 miles to the heart of Washington
description: Text on back: located on Routes 29 and 211 ; 1 mile west of Fairfax, Va. ; direct route to the Skyline Drive
Fragment-based modeling of protein-bound ssRNA
Creators: name: Beauchene, Isaure Chauvot De
name: Vries, Sjoerd De
name: Zacharias, Martin
Publisher: name: F1000Research
Year: 2016

description: Protein-RNA computational docking is hampered by the high flexibility of RNA single-stranded regions, which mostly provide recognition specificity. The huge number of possible conformations of a ssRNA makes it impossible to sample, which limits all protein-RNA docking methods. We developed an original fragment-based approach to model local ssRNA conformations and assemble them on the protein surface. We thus accurately predict ssRNA-protein complexes structure from only protein structure and RNA sequence.

The method consists in:
   (i) cutting the RNA sequence in overlapping trinucleotides, represented by sequence-specific conformers ensembles extracted from known protein-RNA structures
   (ii) docking each conformer-ensemble on the protein
   (iii) selecting the spatially compatible poses
   (iv) assembling them in a realistic conformation.
Moreover, we developed and validated an RNA-protein contacts predictor, based on statistical analysis of known complexes, which provides (optional) starting points for the fragments docking.

We applied this approach on ten complexes with various ssRNA sequences (6-11 nucleotides) bound to different RNA-recognition domains (RRM and PUF). Without predicting specific contacts, we identify the RNA binding site more accurately than all existing methods. Predicting 3-4 contacts, we could model ssRNA with crystallographic-like precision (1-3 A RMSD).
Intra-party decision-making in contemporary Europe: improving representation or ruling with empty shells?
Creators: name: Scarrow, Susan E.
name: Webb, Paul D.
name: Poguntke, Thomas
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Political observers agree that parties in European parliamentary democracies are more likely than previously to give party members opportunities to vote in decisions about party policies or personnel. Observers are less agreed about the implications of these apparent procedural trends. Some, including Peter Mair, saw them as evidence of the hollowing-out of party democracies; others have seen them as enhancing citizens’ opportunities for meaningful political participation. Because this is ultimately an empirical question as well as a normative one, these radically conflicting interpretations make it crucial to examine which interpretation is best supported by usage to date This is the task we undertake in this article. We use data from the Political Party Database Project (PPDB) to investigate the extent to which parties in 26 European countries have adopted and employed intra-party ballots. We also ask whether there is evidence that such procedures are changing intra-party relationships. We find that balloting of party members is indeed widely used, but it is by no means universal. We find much less support for the implication that such ballots are associated with less competitive contests, or that the new devices are generally used in ways that devalue party-member bonds.
Advanced endoscopic imaging for prediction of neoplasia in colorectal polyps
Creators: name: Glover, Benjamin
Publisher: name: Imperial College London
Year: 2022

description: Aims: I hypothesize that characterizing polyps as neoplastic or non-neoplastic is possible using current and emerging technologies, including image-enhanced endoscopy, artificial intelligence (AI), computer-aided diagnosis, and photonics microscopy. I further hypothesize that these methods have sufficient diagnostic accuracy to support resect-and-discard strategy for managing small colorectal polyps. Methods: The research scope was defined by reviewing the current role of colonoscopy in preventing colorectal cancer, particularly focusing on the polypectomy of small adenomas. A meta-analysis of the current diagnostic technologies, such as i-scan and AI-based computer-aided diagnosis, was conducted. A systematic review of emerging technologies like photonics endomicroscopy was also performed. Prototype microscopy platforms for optical coherence tomography (OCT) and multiphoton microscopy (MPT) were developed, with pre-clinical results presented. Results: Current image enhancement technologies enable endoscopists to achieve diagnostic accuracy that meets ASGE standards for the optical diagnosis of colorectal polyps. Specifically, the Pentax i-scan technology demonstrated a sensitivity of 0.92, specificity of 0.90, and negative predictive value of 89.9% for detecting adenomatous pathology in small polyps. Emerging technologies such as OCT, MPT, and hyperspectral imaging show promise, as does AI and computer-aided diagnosis, which achieved a sensitivity of 0.94, specificity of 0.82, and accuracy of 0.90 in meta-analysis. Pre-clinical trials of an integrated OCT/MPT endomicroscope did not meet expectations, requiring separate OCT and MPT subsystems. While optical signals were generated from biological tissue and polyp features were observed in rat colon, the results were not clinically relevant. Conclusions: Colonoscopy with polypectomy of detected neoplastic polyps reduces colorectal cancer incidence. Resect-and-discard or diagnose-and-leave strategies can lower healthcare costs and procedural risks. Image-enhanced endoscopy performed by trained operators, provides adequate diagnostic accuracy for these strategies. AI-based diagnosis shows comparable accuracy. Future technologies like OCT and MPT need further development, as current prototypes, while technically feasible, are not clinically useful or endoscopically deployable.
Sonography and Transthoracic Echocardiography for Diagnosis of Systemic Cardiovascular Metastatic Tumor Thrombi
Creators: name: He, Nan
name: Tang, Xiaobin
name: Lee, Yueh Z.
name: Wang, Sheng
name: Liu, Dan
name: Wang, Xiaona
name: Lai, Yongqiang
name: Jia, Yunfeng
name: Zheng, Ye
name: Yang, Yaoguo
name: Cheng, Yi
name: Zhang, Chun
name: Cheng, Wei
name: Wang, Yongmei
name: Dong, Ran
name: Wang, Jiong
Publisher: name: Wiley
Year: 2016

description: Sonography and transthoracic echocardiography (TTE) are seldom used for assessment of metastatic tumor thrombi in the cardiovascular system in routine clinical practice. We performed this retrospective study to evaluate the combination of sonography with TTE for diagnosis of metastatic tumor thrombi in heart and systemic vessels. Vascular, abdominal, pelvic, and small-part sonography was applied in 18 patients, and TTE was conducted simultaneously in 14 patients. Tumor thrombi invaded into the inferior vena cava system in 12 patients, superior vena cava system in 5 patients, and aorta in 1 patient; they extended to the right cardiac chambers in 11 patients. Six patients had diagnoses by pathologic examination. The primary neoplasms were identified by conventional imaging in 17 patients. The morphologic and echogenic characteristics of the tumor thrombi were diverse and depended on their original tumors. The thrombi were either contiguous or discrete from the original tumors. The neoplastic vascularity of the thrombi and the invasive extension were the primary characteristics that distinguished them from bland thrombi. Simultaneous application of sonography and TTE is a feasible way to comprehensively evaluate cardiovascular metastatic tumor thrombi in most patients.
title: Article: Reston: The New Town Planned to Stop Urban Sprawl, Anonymous, January 28, 1965.
Creators: name: Anonymous
Publisher: name: Engineering News-Record
Year: 1965
Subjects: subject: Reston (Va.)

description: Article: 11" x 8.5" (27.9cm x 21.6cm)
description: Article, "Reston: The New Town Planned to Stop Urban Sprawl," Anonymous, printed in Engineering News-Record, reprinted from January 28, 1965. This article uses Reston to illustrate vital planning principals for controlling the chaotic sprawled development that has consumed land with reckless abandon, created traffic jams and driven community costs skyward in the last twenty years. An early look into Reston's Year 2000 plan; developer Robert E. Simon, planner William J. Conklin; and an editorial about Reston. Planned Communitiy Archives Collection, 444.03.
title: Correspondence: Robert N. Carpenter and C. Harrison Mann, Jr., February 28, 1963-March 3, 1963
Creators: name: Carpenter, Robert N.
name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2005
Subjects: subject: Racial intermarriage

description: Letter A: typescript signed, 10.5" x 8" (26.7 cm x 20.3 cm); Letter B: typescript unsigned, 11" x 8.5" (29.7 cm x 21.6 cm)
description: Correspondence between C. Harrison Mann, Jr. and Capitan Robert N. Carpenter regarding racial inter-marriage and a Virginia law which prohibits it. C. Harrison Mann, Jr. Collection 2.08
title: Creating an Organisational Data Policy: Processes & Reflections from the Museum für Naturkunde Berlin
Creators: name: Thorn, Caitlin Lara
name: Petersen, Mareike
Publisher: name: Museum für Naturkunde - Leibniz-Institut für Evolutions- und Biodiversitätsforschung
Year: 2025
Subjects: research data management

description: The responsible handling of research data is vital for fostering scientific progress, disseminating knowledge, and ensuring the traceability of research. The digital transformation of research and society presents new challenges, necessitating central guidelines within research institutions and communities.

To address these challenges, the Museum für Naturkunde Berlin (MfN) developed a comprehensive and adaptable catalogue of measures, including recommendations, procedural instructions, and various documentation forms. This catalogue is designed to be maintained and regularly updated to reflect the state of the art. The resulting data policy fills a gap in formal guidance on research and scientific data publication at the MfN.

Developing this policy required input from multiple stakeholders and consideration of all aspects of Research Data Management (RDM), including governance, storage, access, and adherence to FAIR principles. The final policy provides a framework that spans the entire data life cycle, ensuring sustainable and transparent data management.

From this, we share our process, and reflect on key learnings from the policy’s development and publication, offering insights that can guide other research institutions and RDM teams in successfully creating and implementing their own data policies.