cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Phase diagram of the La$_{1-x}$Ca$_{x}$MnO$_{3}$ compound for $0.5\leq x\leq 0.9$
Creators: name: Pissas, M.
name: Kallias, G.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have studied the phase diagram of La$_{1-x}$Ca$_{x}$MnO$_{3}$ for $0.5\leq x\leq 0.9$ using neutron powder diffraction and magnetization measurements. At 300 K all samples are paramagnetic and single phase with crystallographic symmetry $Pnma$. As the temperature is reduced a structural transition is observed which is to a charge-ordered state only for certain x. On further cooling the material passes to an antiferromagnetic ground state with Neel temperature $T_N$ that depends on x. For $0.8\leq x\leq 0.9$ the structural transformation occurs at the same temperature as the magnetic transition. Overall, the neutron diffraction patterns were explained by considering four phase boundaries for which La$_{1-x}$Ca$_x$MnO$_3$ forms a distinct phase: the CE phase at $x=0.5-0.55$, the charge-ordered phase at x=2/3, the monoclinic and C-type magnetic structure at $x=0.80-0.85$ and the G-type magnetic structure at x=1. Between these phase boundaries the magnetic reflections suggest the existence of mixed compounds containing both phases of the adjacent phase boundaries in a ratio determined by the lever rule.
Transcriptomics predicts compound synergy in drug and natural product treated glioblastoma cells
Creators: name: Pruteanu, Lavinia-Lorena
name: Kopanitsa, Liliya
name: Módos, Dezső
name: Kletnieks, Edgars
name: Samarova, Elena
name: Bender, Andreas
name: Gomez, Leonardo Dario
name: Bailey, David Stanley
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Research Article
subject: Biology and life sciences
subject: Medicine and health sciences
subject: Engineering and technology
subject: FOS: Engineering and technology
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: Pathway analysis is an informative method for comparing and contrasting drug-induced gene expression in cellular systems. Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with the prototypic phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002, on gene expression in a well-established human glioblastoma cell system, U87MG. Under conditions which inhibit cell proliferation, LY-294002 and fucoxanthin modulate many pathways in common, including the retinoblastoma, DNA damage, DNA replication and cell cycle pathways. In sharp contrast, we see profound differences in the expression of genes characteristic of pathways such as apoptosis and lipid metabolism, contributing to the development of a differentiated and distinctive drug-induced gene expression signature for each compound. Furthermore, in combination, fucoxanthin synergizes with LY-294002 in inhibiting the growth of U87MG cells, suggesting complementarity in their molecular modes of action and pointing to further treatment combinations. The synergy we observe between the dietary nutraceutical fucoxanthin and the synthetic chemical LY-294002 in producing growth arrest in glioblastoma, illustrates the potential of nutri-pharmaceutical combinations in targeting this challenging disease.
Probing Disk Accretion in Young Brown Dwarfs
Creators: name: Jayawardhana, Ray
name: Mohanty, Subhanjoy
name: Basri, Gibor
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present high-resolution optical spectra of 15 objects near or below the sub-stellar limit in the Upper Scorpius and $ρ$ Ophiuchus star-forming regions. These spectra, obtained with the HIRES instrument on the Keck I telescope, are used to investigate disk accretion, rotation and activity in young very low mass objects. We report the detection of a broad, asymmetric H$α$ emission line in the $ρ$ Oph source GY 5 which is also known to harbor mid-infrared excess, consistent with the presence of an accreting disk. The H$α$ profiles of the Upper Sco objects suggest little or no on-going accretion. Our results imply that if most brown dwarfs are born with disks, their accretion rates decrease rapidly, at timescales comparable to or smaller than those for T Tauri disks. The Upper Sco brown dwarfs appear to be rotating faster than their somewhat younger counterparts in Taurus, consistent with spin-up due to contraction following disk unlocking. The H$α$ activity is comparable to saturated activity levels in field M dwarfs with similar spectral type and rotation rates. Comparison of our data with published (albeit lower-resolution) spectra of a few of the same objects from other epochs suggests possible variability in accretion/activity indicators.
description: to appear in The Astrophysical Journal Letters
Additional file 2: of Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review protocol
Creators: name: Gauruv Bose
name: Graveline, Justin
name: Vignan Yogendrakumar
name: Fergusson, Dean
name: Dar Dowlatshahi
Publisher: name: figshare
Year: 2019
Subjects: Medicine
Pharmacology
Computational Biology

description: PRISMA-P checklist [8]. (DOCX 22 kb)
Additional file 6 of Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
Creators: name: Li, Tianqi
name: Chan, Rachel W.S.
name: Li, Raymond H.W.
name: Ng, Ernest H.Y.
name: Zhang, Songying
name: Yeung, William S.B.
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Supplementary Material 6
Accelerated Structured Alternating Projections for Robust Spectrally Sparse Signal Recovery
Creators: name: Cai, HanQin
name: Cai, Jian-Feng
name: Wang, Tianming
name: Yin, Guojian
Publisher: name: arXiv
Year: 2019
Subjects: subject: Information Theory (cs.IT)
subject: Machine Learning (cs.LG)
subject: Signal Processing (eess.SP)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics

description: Consider a spectrally sparse signal $\boldsymbol{x}$ that consists of $r$ complex sinusoids with or without damping. We study the robust recovery problem for the spectrally sparse signal under the fully observed setting, which is about recovering $\boldsymbol{x}$ and a sparse corruption vector $\boldsymbol{s}$ from their sum $\boldsymbol{z}=\boldsymbol{x}+\boldsymbol{s}$. In this paper, we exploit the low-rank property of the Hankel matrix formed by $\boldsymbol{x}$, and formulate the problem as the robust recovery of a corrupted low-rank Hankel matrix. We develop a highly efficient non-convex algorithm, coined Accelerated Structured Alternating Projections (ASAP). The high computational efficiency and low space complexity of ASAP are achieved by fast computations involving structured matrices, and a subspace projection method for accelerated low-rank approximation. Theoretical recovery guarantee with a linear convergence rate has been established for ASAP, under some mild assumptions on $\boldsymbol{x}$ and $\boldsymbol{s}$. Empirical performance comparisons on both synthetic and real-world data confirm the advantages of ASAP, in terms of computational efficiency and robustness aspects.
Chinese consumer’s perceptions of beef
Creators: name: Liu, Hongbo
name: Parton, Kevin A.
name: Cox, Rodney J.
name: Liu, Hongbo
name: Parton, Kevin A.
name: Cox, Rodney J.
Publisher: name: Unknown
Year: 2006
Subjects: subject: Farm Management
subject: beef
subject: consumer’s perception
subject: Chinese beef consumption

description: China has experienced rapid economic growth over the last 26 years. As per capita income has increased, household consumption has become greatly diversified, and many food new products have entered the market. Beef is slowly gaining ground relative to the more traditional pork products. This research examined factors affecting beef purchasing decisions in China. The effect of socioeconomic and demographic characteristics, together with other influences on preferences, was analysed using probit regression analysis. Compared with other meats, the relatively high price of beef (34%) and consumers’ unfamiliarity with its cooking method (26%) are the main limitations for beef consumption. These are followed by ‘don’t like the taste and smell’ which shows that compared with pork, beef is still relatively new to Chinese consumers and some of them are not used to the flavour of beef products. Han Chinese are more ready to accept beef than Non-Han Chinese. The characteristics of target consumers who show a preference towards beef are: residents of urban areas, a small family or a family with more males over 16 years old, the young (below 45 years old) and well educated, possessing a good income and who considered safety, price and ease of preparation as important purchasing criteria.
Classification of Conformal Field Theories Based on Coulomb gases. Application to Loop Models
Creators: name: Dotsenko, Vladimir S.
name: Jacobsen, Jesper Lykke
name: Picco, Marco
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present a method for classifying conformal field theories based on Coulomb gases (bosonic free-field construction). Given a particular geometric configuration of the screening charges, we give necessary conditions for the existence of degenerate representations and for the closure of the vertex-operator algebra. The resulting classification contains, but is more general than, the standard one based on classical Lie algebras. We then apply the method to the Coulomb gas theory for the two-flavoured loop model of Jacobsen and Kondev. The purpose of the study is to clarify the relation between Coulomb gas models and conformal field theories with extended symmetries.
description: LaTeX, 34 pages, 8 figures
Pseudosmittia roquei Andersen, Saether et Mendes
Creators: name: Ferrington Jr, Leonard C.
name: Saether, Ole A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Pseudosmittia
Pseudosmittia roquei

description: Pseudosmittia roquei Andersen, Saether et Mendes
(Fig. 109 A–C)
 Pseudosmittia roquei Andersen, Saether et Mendes, 2010: 63.
 Material examined: BRAZIL: Minas Gerais, Monte Verde, Camanducaia, holotype male, 20.viii.2004, F. O. Roque (MZUSP). Other material as in Andersen et al. (2010: 63).
 Diagnostic characters: The male imago can be separated from other species with bifurcate gonostylus by the absence of an anal point, and the distinct second lobe of the apparent median volsella.
 This species from Minas Gerais, São Paulo State and Santa Catarina State, Brazil, is described in detail by Andersen et al. (2010: 63)
description: Published as part of Ferrington Jr, Leonard C. & Saether, Ole A., 2011, A revision of the genera Pseudosmittia Edwards, 1932, Allocladius Kieffer, 1913, and Hydrosmittia gen. n. (Diptera: Chironomidae, Orthocladiinae) 2849, pp. 1-314 in Zootaxa 2849 (1) on pages 283-284, DOI: 10.11646/zootaxa.2849.1.1, http://zenodo.org/record/5288200
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Creators: name: Hill, W. David
name: Davies, Neil M.
name: Ritchie, Stuart J.
name: Skene, Nathan G.
name: Bryois, Julien
name: Bell, Steven
name: Di Angelantonio, Emanuele
name: Roberts, David J.
name: Xueyi, Shen
name: Davies, Gail
name: Liewald, David C. M.
name: Porteous, David J.
name: Hayward, Caroline
name: Butterworth, Adam S.
name: McIntosh, Andrew M.
name: Gale, Catharine R.
name: Deary, Ian J.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/208/205/2138
/706/689/159
/706/689/477/2811
/706/689/522
/45/43
/38
/38/43
article

description: Abstract: Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a sample of 286,301 participants from UK Biobank, we identify 30 (29 previously unreported) independent-loci associated with income. Using a method to meta-analyze data from genetically-correlated traits, we identify an additional 120 income-associated loci. These loci show clear evidence of functionality, with transcriptional differences identified across multiple cortical tissues, and links to GABAergic and serotonergic neurotransmission. By combining our genome wide association study on income with data from eQTL studies and chromatin interactions, 24 genes are prioritized for follow up, 18 of which were previously associated with intelligence. We identify intelligence as one of the likely causal, partly-heritable phenotypes that might bridge the gap between molecular genetic inheritance and phenotypic consequence in terms of income differences. These results indicate that, in modern era Great Britain, genetic effects contribute towards some of the observed socioeconomic inequalities.
Analyzing the Forgetting Problem in the Pretrain-Finetuning of Dialogue Response Models
Creators: name: He, Tianxing
name: Liu, Jun
name: Cho, Kyunghyun
name: Ott, Myle
name: Liu, Bing
name: Glass, James
name: Peng, Fuchun
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: In this work, we study how the finetuning stage in the pretrain-finetune framework changes the behavior of a pretrained neural language generator. We focus on the transformer encoder-decoder model for the open-domain dialogue response generation task. Our major finding is that after standard finetuning, the model forgets some of the important language generation skills acquired during large-scale pretraining. We demonstrate the forgetting phenomenon through a set of detailed behavior analysis from the perspectives of knowledge transfer, context sensitivity, and function space projection. As a preliminary attempt to alleviate the forgetting problem, we propose an intuitive finetuning strategy named "mix-review". We find that mix-review effectively regularizes the finetuning process, and the forgetting problem is alleviated to some extent. Finally, we discuss interesting behavior of the resulting dialogue model and its implications.
Economic and Nutritional Implications from Changes in U.S. Agricultural Promotion Efforts
Creators: name: Ho, Shuay-Tsyr
name: Rickard, Bradley J.
name: Liaukonyte, Jura
name: Ho, Shuay-Tsyr
name: Rickard, Bradley J.
name: Liaukonyte, Jura
Publisher: name: Unknown
Year: 2014
Subjects: subject: Agribusiness
subject: International Relations/Trade
subject: Marketing
subject: FOS: Economics and business
subject: advertising
subject: export promotion
subject: horticulture
subject: nutrient intake
subject: policy reform
subject: simulation model

description: Promotion programs that subsidize advertising for exported agricultural products continue to be used despite much criticism that they are an inefficient use of taxpayer money. At the same time, others have advocated for an increase in funds to support domestic advertising for fruits and vegetables. We investigate the economic and nutritional effects from changes in both export and domestic promotion expenditures for horticultural and nonhorticultural commodities. Simulation results show that even modest decreases in trade promotion expenditures coupled with a corresponding increase in domestic promotion efforts have the capacity to influence domestic market conditions, caloric intake, and nutrient consumption.
Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury: A CENTER-TBI high-resolution group study
Creators: name: Åkerlund, Cecilia AI
name: Donnelly, Joseph
name: Zeiler, Frederick A.
name: Helbok, Raimund
name: Holst, Anders
name: Cabeleira, Manuel
name: Güiza, Fabian
name: Meyfroidt, Geert
name: Czosnyka, Marek
name: Smielewski, Peter
name: Stocchetti, Nino
name: Ercole, Ari
name: Nelson, David W.
name: Participants, The CENTER-TBI High Resolution ICU Sub-Study
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Research Article
subject: Medicine and health sciences
subject: Research and analysis methods
subject: Biology and life sciences
subject: Social sciences
subject: FOS: Social sciences

description: Magnitude of intracranial pressure (ICP) elevations and their duration have been associated with worse outcomes in patients with traumatic brain injuries (TBI), however published thresholds for injury vary and uncertainty about these levels has received relatively little attention. In this study, we have analyzed high-resolution ICP monitoring data in 227 adult patients in the CENTER-TBI dataset. Our aim was to identify thresholds of ICP intensity and duration associated with worse outcome, and to evaluate the uncertainty in any such thresholds. We present ICP intensity and duration plots to visualize the relationship between ICP events and outcome. We also introduced a novel bootstrap technique to evaluate uncertainty of the equipoise line. We found that an intensity threshold of 18 ± 4 mmHg (2 standard deviations) was associated with worse outcomes in this cohort. In contrast, the uncertainty in what duration is associated with harm was larger, and safe durations were found to be population dependent. The pressure and time dose (PTD) was also calculated as area under the curve above thresholds of ICP. A relationship between PTD and mortality could be established, as well as for unfavourable outcome. This relationship remained valid for mortality but not unfavourable outcome after adjusting for IMPACT core variables and maximum therapy intensity level. Importantly, during periods of impaired autoregulation (defined as pressure reactivity index (PRx)>0.3) ICP events were associated with worse outcomes for nearly all durations and ICP levels in this cohort and there was a stronger relationship between outcome and PTD. Whilst caution should be exercised in ascribing causation in observational analyses, these results suggest intracranial hypertension is poorly tolerated in the presence of impaired autoregulation. ICP level guidelines may need to be revised in the future taking into account cerebrovascular autoregulation status considered jointly with ICP levels.
Variations in Toll Road Impacts: Case Studies from Texas
Creators: name: Kalmanje, Sukumar
name: Kockelman, Kara M.
name: Kalmanje, Sukumar
name: Kockelman, Kara M.
Publisher: name: Unknown
Year: 2009
Subjects: Public Economics

description: Facing funding shortfalls for infrastructure construction and maintenance, many urban regions are seeking to develop new toll roads. These can diversely impact a region’s traffic, land use, economy and citizens’ welfare. Regions have distinct network configurations, spatial and temporal variation in demand patterns, as well as road user characteristics affecting their response to such roads. This paper illuminates the nature of variations in impacts by consistently modeling and comparing the effects of adding toll roads to three distinct Texas regions with geographical proximity: Austin, Dallas-Fort Worth (DFW) and El Paso. Initial models were calibrated for the Austin region and then appropriately adapted to the DFW and El Paso regions. While impacts varied by region, all cases suggested impacts were greatest near the toll roads, with welfare improvements falling with distance in DFW and El Paso and toll road end points gaining the most in Austin.
Additional file 5: of Metabolic and signalling network maps integration: application to cross-talk studies and omics data analysis in cancer
Creators: name: Sompairac, Nicolas
name: Modamio, Jennifer
name: Barillot, Emmanuel
name: Fleming, Ronan
name: Zinovyev, Andrei
name: Kuperstein, Inna
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Crosstalk between ACSN modules and ReconMap 2.0 metabolic pathways. Using the composition of each module and subsystem (Additional files 3 and 4) and the list of the 252 shared proteins between both maps, modules and subsystems having common proteins were linked together. Thus, a crosstalk between both maps has been uncovered with the number of shared proteins showed here. *Modules and subsystems in bold are the result of an Enrichment Analysis of the 252 common proteins between ACSN and ReconMap 2. (DOCX 16 kb)
Granularity-induced gapless superconductivity in NbN films: evidence of thermal phase fluctuations
Creators: name: Lamura, G.
name: Villegier, J. C.
name: Gauzzi, A.
name: Cochec, J. Le
name: Laval, J. Y.
name: Placais, B.
name: Hadacek, N.
name: Bok, J.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Using a single coil mutual inductance technique, we measure the low temperature dependence of the magnetic penetration depth in superconducting NbN films prepared with similar critical temperatures around 16 K but with different microstructures. Only (100) epitaxial and weakly granular (100) textured films display the characteristic exponential dependence of conventional BCS s-wave superconductors. More granular (111) textured films exhibit a linear dependence, indicating a gapless state in spite of the s-wave gap. This result is quantitatively explained by a model of thermal phase fluctuations favored by the granular structure.
description: 10 pages, 4 figures, to appear in Phys. Rev. B
Process evaluation of implementation fidelity of the integrated chronic disease management model in two districts, South Africa
Creators: name: Lebina, Limakatso
name: Alaba, Olufunke
name: Ringane, Ashley
name: Hlongwane, Khuthadzo
name: Pule, Pogiso
name: Oni, Tolu
name: Kawonga, Mary
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Research Article
Organization, structure and delivery of healthcare
Intervention adherence
ICDM model
Chronic care model
Implementation research
Value stream mapping

description: Funder: South African Medical Research Council; doi: http://dx.doi.org/10.13039/501100001322; Grant(s): ID:494184
description: Abstract: Background: The Integrated Chronic Disease Management (ICDM) model has been implemented in South Africa to enhance quality of clinical services in Primary Healthcare (PHC) clinics in a context of a high prevalence of chronic conditions and multi-morbidity. This study aimed to assess the implementation fidelity (adherence to guidelines) of the ICDM model. Methods: A cross-sectional study in 16 PHC clinics in two health districts in South Africa: Dr. Kenneth Kaunda (DKK) and West Rand (WR). A fidelity assessment tool with 89 activities and maximum score of 158 was developed from the four interrelated ICDM model components: facility re-organization, clinical supportive management, assisted self-management and strengthening of support systems. Value stream mapping of patient flow was conducted to analyse waiting time and identify operational inefficiencies. ICDM items were scored based on structured observations, facility document reviews and structured questionnaires completed by healthcare workers. Fidelity scores were summarized using medians and proportions and compared by facilities and districts using Chi-Square and Kruskal Wallis test. Results: The monthly patient headcount over a six-month period in these 16 PHC clinics was a median of 2430 (IQR: 1685–2942) individuals over 20 years. The DKK district had more newly diagnosed TB patients per month [median 5.5 (IQR: 4.00–9.33) vs 2.0 (IQR: 1.67–2.92)], and fewer medical officers per clinic [median 1 (IQR: 1–1) vs 3.5 (IQR:2–4.5)] compared to WR district. The median fidelity scores in both districts for facility re-organization, clinical supportive management, assisted self-management and strengthening of support systems were 78% [29/37, IQR: 27–31)]; 77% [30/39 (IQR: 27–34)]; 77% [30/39 (IQR: 28–34)]; and 80% [35/44 (IQR: 30–37)], respectively. The overall median implementation fidelity of the ICDM model was 79% (125/158, IQR, 117–132); WR was 80% (126/158, IQR, 123–132) while DKK was 74% (117/158, IQR, 106–130), p = 0.1409. The lowest clinic fidelity score was 66% (104/158), while the highest was 86% (136/158). A patient flow analysis showed long (2–5 h) waiting times and one stream of care for acute and chronic services. Conclusion: There was some variability of scores on components of the ICDM model by PHC clinics. More research is needed on contextual adaptations of the model.
Railroad Economies of Scale, Scope, and Density Revisited
Creators: name: Bereskin, C. Gregory
name: Bereskin, C. Gregory
Publisher: name: Unknown
Year: 2009
Subjects: Public Economics

description: The movement of freight on railroads is subject to a number of technological characteristics that make costing of specific traffic a complex process. Among these restrictions are conditions of joint production, economies of scale, scope, and density, and a lack of data on specific expenditures related to individual freight movements. In this paper, an econometric cost model using publicly available data and methodology is developed for the examination of average and marginal costs in the industry. The model is decomposed into individual elasticity estimates for operating parameters to examine economies of scope. Finally, the size of the firm is varied through multiplying the capital stock measurements and estimating the cost behavior as firm capital stock is varied between one-quarter and two times the level of 2005. Results indicate that the railroad industry has effectively exhausted the possible economies of scale but can still gain from economies of density and scope. In addition, there appears to be little economic justification for mergers creating transcontinental railroad systems.
Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
Creators: name: Sasmono, R. Tedjo
name: Santoso, Marsha S.
name: Pamai, Yanuarni W. B.
name: Yohan, Benediktus
name: Afida, Anna M.
name: Denis, Dionisius
name: Hutagalung, Ingrid A.
name: Johar, Edison
name: Hayati, Rahma F.
name: Yudhaputri, Frilasita A.
name: Haryanto, Sotianingsih
name: Stubbs, Samuel C. B.
name: Blacklaws, Barbara A.
name: Myint, Khin S. A.
name: Frost, Simon D. W.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Medicine
arbovirus
dengue
serotypes
chikungunya
clinical
Indonesia

description: The people of Indonesia have been afflicted by dengue, a mosquito-borne viral disease, for over 5 decades. The country is the world's largest archipelago with diverse geographic, climatic, and demographic conditions that may impact the dynamics of disease transmissions. A dengue epidemiology study was launched by us to compare and understand the dynamics of dengue and other arboviral diseases in three cities representing western, central, and eastern Indonesia, namely, Batam, Banjarmasin, and Ambon, respectively. A total of 732 febrile patients were recruited with dengue-like illness during September 2017–2019 and an analysis of their demographic, clinical, and virological features was performed. The seasonal patterns of dengue-like illness were found to be different in the three regions. Among all patients, 271 (37.0%) were virologically confirmed dengue, while 152 (20.8%) patients were diagnosed with probable dengue, giving a total number of 423 (57.8%) dengue patients. Patients' age and clinical manifestations also differed between cities. Mostly, mild dengue fever was observed in Batam, while more severe cases were prominent in Ambon. While all dengue virus (DENV) serotypes were detected, distinct serotypes dominated in different locations: DENV-1 in Batam and Ambon, and DENV-3 in Banjarmasin. We also assessed the diagnostic features in the study sites, which revealed different patterns of diagnostic agreements, particularly in Ambon. To detect the possibility of infection with other arboviruses, further testing on 461 DENV RT-PCR-negative samples was performed using pan-flavivirus and -alphavirus RT-PCRs; however, only one chikungunya infection was detected in Ambon. A diverse dengue epidemiology in western, central, and eastern Indonesia was observed, which is likely to be influenced by local geographic, climatic, and demographic conditions, as well as differences in the quality of healthcare providers and facilities. Our study adds a new understanding on dengue epidemiology in Indonesia.
Additional file 7: of Metabolic and signalling network maps integration: application to cross-talk studies and omics data analysis in cancer
Creators: name: Sompairac, Nicolas
name: Modamio, Jennifer
name: Barillot, Emmanuel
name: Fleming, Ronan
name: Zinovyev, Andrei
name: Kuperstein, Inna
Publisher: name: figshare
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Regulations of reactions in ReconMap 2.0 subsystems by proteins found in ACSN modules. The information encoded in the annotations of reactions and entities on the CellDesigner XML files was analysed and the correspondence between shared proteins in ACSN modules to regulated reactions in ReconMap 2.0 subsystems was retrieved and quantified. Number of ReconMap 2.0 reaction regulated by a subset of shared proteins is shown. (DOCX 17 kb)
Additional file 1 of Relationship between maximal oxygen uptake, within-set fatigue and between-set recovery during resistance exercise in resistance-trained men and women
Creators: name: Lundberg, Tommy R.
name: Larsson, Gustav
name: Alstermark, Rasmus
name: Mandić, Mirko
name: Fernandez-Gonzalo, Rodrigo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Supplementary Material 1
On Hausdorff measure and an inequality due to Maz'ya
Creators: name: Vogt, Hendrik
name: Voigt, Jürgen
Publisher: name: arXiv
Year: 2019
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 49Q15, 28A75, 46E35

description: We give an "elementary" proof of an inequality due to Maz'ya. As a prerequisite we prove an approximation property for the Hausdorff measure. We also comment on the relations between Maz'ya's inequality, the isoperimetric inequality and the Sobolev inequality.
Study of Driver’s Behavior at Passive Railroad‐Highway Grade Crossings
Creators: name: Rys, Margaret J.
name: Shah, Harshit D.
name: Russell, Eugene E.
name: Rys, Margaret J.
name: Shah, Harshit D.
name: Russell, Eugene E.
Publisher: name: Unknown
Year: 2009
Subjects: Public Economics

description: Railway highway grade crossing safety has always been a concern for railroads, state DOTs, and the driving population. This paper presents an overview of drivers’ behavior at different passive warning sign systems present at a selected number of Kansas railroad-highway grade crossings. Emphasis in this study was on drivers’ stopping behavior at the STOP signs, as that has been a major concern of Kansas DOT (KDOT). A field study was conducted on nine grade crossings with selected warning devices to determine driver’s approach behavior, particularly stopping behavior at STOP signs. Various statistical analysis and comparisons are done for stopping of heavy trucks, school buses and other vehicles at crossings with both poor and good sight distance on their approaches. Based on the field tests conducted it was found that the majority of drivers did not stop at the STOP signs at the grade crossings. A higher percentage of drivers actually stopped at crossings with poor sight distance on the approach than on approaches with good sight distance. The use of the STOP sign at passive grade crossings has been controversial for several decades. This paper presents a brief history of their use and the controversy. Based on this limited study, the authors recommended that a STOP sign should not be used at grade crossings without a valid engineering study that includes an evaluation of the sight distance.
Influence of mild-moderate hypocapnia on intracranial pressure slow waves activity in TBI
Creators: name: Beqiri, Erta
name: Czosnyka, Marek
name: Lalou, Afroditi D.
name: Zeiler, Frederick A.
name: Fedriga, Marta
name: Steiner, Luzius A.
name: Chieregato, Arturo
name: Smielewski, Peter
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Original Article - Brain trauma
Brain trauma
ICP slow waves
Hypocapnia
TBI
Cerebral autoregulation
Compensatory reserve
RAP

description: Funder: University of Cambridge
description: Abstract: Background: In traumatic brain injury (TBI) the patterns of intracranial pressure (ICP) waveforms may reflect pathological processes that ultimately lead to unfavorable outcome. In particular, ICP slow waves (sw) (0.005–0.05 Hz) magnitude and complexity have been shown to have positive association with favorable outcome. Mild-moderate hypocapnia is currently used for short periods to treat critical elevations in ICP. Our goals were to assess changes in the ICP sw activity occurring following sudden onset of mild-moderate hypocapnia and to examine the relationship between changes in ICP sw activity and other physiological variables during the hypocapnic challenge. Methods: ICP, arterial blood pressure (ABP), and bilateral middle cerebral artery blood flow velocity (FV), were prospectively collected in 29 adult severe TBI patients requiring ICP monitoring and mechanical ventilation in whom a minute volume ventilation increase (15–20% increase in respiratory minute volume) was performed as part of a clinical CO2-reactivity test. The time series were first treated using FFT filter (pass-band set to 0.005–0.05 Hz). Power spectral density analysis was performed. We calculated the following: mean value, standard deviation, variance and coefficient of variation in the time domain; total power and frequency centroid in the frequency domain; cerebrospinal compliance (Ci) and compensatory reserve index (RAP). Results: Hypocapnia led to a decrease in power and increase in frequency centroid and entropy of slow waves in ICP and FV (not ABP). In a multiple linear regression model, RAP at the baseline was the strongest predictor for the decrease in the power of ICP slow waves (p < 0.001). Conclusion: In severe TBI patients, a sudden mild-moderate hypocapnia induces a decrease in mean ICP and FV, but also in slow waves power of both signals. At the same time, it increases their higher frequency content and their morphological complexity. The difference in power of the ICP slow waves between the baseline and the hypocapnia period depends on the baseline cerebrospinal compensatory reserve as measured by RAP.
Pseudosmittia adunca Andersen, Saether et Mendes
Creators: name: Ferrington Jr, Leonard C.
name: Saether, Ole A.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Pseudosmittia
Pseudosmittia adunca

description: Pseudosmittia adunca Andersen, Saether et Mendes
(Fig. 110 A, B)
 Pseudosmittia adunca Andersen, Saether et Mendes, 2010: 26.
 Material examined: BRAZIL: Santa Catarina State, Jaraguá do Sul, emergence trap (soil), holotype male, 14.v.– 2.viii.2003, A.P. Dias et al. (IOC). Other material as in Andersen et al. (2010: 26).
 Diagnostic characters: The male imago can be separated from other species with bifurcate gonostylus by the long, inward curved secondary lobe of the gonostylus and the long anterior lobe of the median volsella.
 This Brazilian species from Santa Catarina State is described in detail in Andersen et al. (2010: 26).
description: Published as part of Ferrington Jr, Leonard C. & Saether, Ole A., 2011, A revision of the genera Pseudosmittia Edwards, 1932, Allocladius Kieffer, 1913, and Hydrosmittia gen. n. (Diptera: Chironomidae, Orthocladiinae) 2849, pp. 1-314 in Zootaxa 2849 (1) on page 284, DOI: 10.11646/zootaxa.2849.1.1, http://zenodo.org/record/5288200
Additional file 6: of Metabolic and signalling network maps integration: application to cross-talk studies and omics data analysis in cancer
Creators: name: Sompairac, Nicolas
name: Modamio, Jennifer
name: Barillot, Emmanuel
name: Fleming, Ronan
name: Zinovyev, Andrei
name: Kuperstein, Inna
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology

description: Enrichment analysis of common proteins between ACSN modules and ReconMap 2.0 metabolic pathways. Enrichment Analysis of the 252 common proteins between ACSN and ReconMap 2.0 was performed using the Survival Function Method on the union of proteins of both maps. The p-value is obtained through a standard Hypergeometric test on modules containing at least 10 proteins using a Bonferroni adjustment for the multiple testing correction. (DOCX 14 kb)
Analysis of Factors Influencing Grain Traffic on the St. Lawrence Seaway
Creators: name: Fuller, Stephen
name: Millerd, Frank
name: Fraire, Francisco
name: Do Carmo Afonso, Maria
name: Fuller, Stephen
name: Millerd, Frank
name: Fraire, Francisco
name: Do Carmo Afonso, Maria
Publisher: name: Unknown
Year: 2009
Subjects: Public Economics

description: The St. Lawrence Seaway links central regions of North America to the Atlantic Ocean via the Great Lakes navigation system. Harmful non-indigenous aquatic invasive species have increasingly been introduced into the Great Lakes largely through the ballast water of inbound ships involved in international commerce. A variety of solutions have been proposed, with some advocating closure of the St. Lawrence Seaway to international shipping.Historically, it was an important artery linking grain surplus regions in Canada and the United States with international markets. However, during the past two decades the Seaway’s role has diminished as a grain transport artery. The objective of this paper is to develop an increased understanding of this decline and to offer thoughts regarding the likely reversal of the forces that may have caused it. Analysis indicates declining imports by selected world regions and domestic transportation legislation is central to the decline.
Experimental Lagos bat virus infection in straw-colored fruit bats: A suitable model for bat rabies in a natural reservoir species
Creators: name: Begeman, Lineke
name: Suu-Ire, Richard
name: Banyard, Ashley C.
name: Drosten, Christian
name: Eggerbauer, Elisa
name: Freuling, Conrad M.
name: Gibson, Louise
name: Goharriz, Hooman
name: Horton, Daniel L.
name: Jennings, Daisy
name: Marston, Denise A.
name: Ntiamoa-Baidu, Yaa
name: Riesle Sbarbaro, Silke
name: Selden, David
name: Wise, Emma L.
name: Kuiken, Thijs
name: Fooks, Anthony R.
name: Müller, Thomas
name: Wood, James L. N.
name: Cunningham, Andrew A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
Biology and life sciences
Medicine and health sciences

description: Funder: Royal Society Wolfson Research Merit award
description: Rabies is a fatal neurologic disease caused by lyssavirus infection. Bats are important natural reservoir hosts of various lyssaviruses that can be transmitted to people. The epidemiology and pathogenesis of rabies in bats are poorly understood, making it difficult to prevent zoonotic transmission. To further our understanding of lyssavirus pathogenesis in a natural bat host, an experimental model using straw-colored fruit bats (Eidolon helvum) and Lagos bat virus, an endemic lyssavirus in this species, was developed. To determine the lowest viral dose resulting in 100% productive infection, bats in five groups (four bats per group) were inoculated intramuscularly with one of five doses, ranging from 100.1 to 104.1 median tissue culture infectious dose (TCID50). More bats died due to the development of rabies after the middle dose (102.1 TCID50, 4/4 bats) than after lower (101.1, 2/4; 101.1, 2/4) or higher (103.1, 2/4; 104.1, 2/4) doses of virus. In the two highest dose groups, 4/8 bats developed rabies. Of those bats that remained healthy 3/4 bats seroconverted, suggesting that high antigen loads can trigger a strong immune response that abrogates a productive infection. In contrast, in the two lowest dose groups, 3/8 bats developed rabies, 1/8 remained healthy and seroconverted and 4/8 bats remained healthy and did not seroconvert, suggesting these doses are too low to reliably induce infection. The main lesion in all clinically affected bats was meningoencephalitis associated with lyssavirus-positive neurons. Lyssavirus antigen was detected in tongue epithelium (5/11 infected bats) rather than in salivary gland epithelium (0/11), suggesting viral excretion via the tongue. Thus, intramuscular inoculation of 102.1 TCID50 of Lagos bat virus into straw-colored fruit bats is a suitable model for lyssavirus associated bat rabies in a natural reservoir host, and can help with the investigation of lyssavirus infection dynamics in bats.
Safety Effectiveness of Offsetting Opposing Left‐Turn Lanes: A Case Study
Creators: name: Naik, Bhaven
name: Appiah, Justice
name: Khattak, Aemal J.
name: Rilett, Laurence R.
name: Naik, Bhaven
name: Appiah, Justice
name: Khattak, Aemal J.
name: Rilett, Laurence R.
Publisher: name: Unknown
Year: 2009
Subjects: Public Economics

description: This paper discusses the benefits to intersection safety of offsetting left-turn lanes by widening the width of the lane-line marking between the left-turn lanes and their adjacent through lanes. The analysis was performed using an empirical Baye’s procedure in order to account for potential bias due to regression-to-the-mean. Results from the analysis of 12 treated intersection approaches and 36 non-treated approaches in Lincoln, Nebraska, suggest statistically significant improvements in safety at the treated intersections.
Hierarchical population model with a carrying capacity distribution
Creators: name: Indekeu, J. O.
name: Sznajd-Weron, K.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: A time- and space-discrete model for the growth of a rapidly saturating local biological population $N(x,t)$ is derived from a hierarchical random deposition process previously studied in statistical physics. Two biologically relevant parameters, the probabilities of birth, $B$, and of death, $D$, determine the carrying capacity $K$. Due to the randomness the population depends strongly on position, $x$, and there is a distribution of carrying capacities, $Π(K)$. This distribution has self-similar character owing to the imposed hierarchy. The most probable carrying capacity and its probability are studied as a function of $B$ and $D$. The effective growth rate decreases with time, roughly as in a Verhulst process. The model is possibly applicable, for example, to bacteria forming a "towering pillar" biofilm. The bacteria divide on randomly distributed nutrient-rich regions and are exposed to random local bactericidal agent (antibiotic spray). A gradual overall temperature change away from optimal growth conditions, for instance, reduces bacterial reproduction, while biofilm development degrades antimicrobial susceptibility, causing stagnation into a stationary state.
description: 25 pages, 11 (9+2) figures
When does Diversity Help Generalization in Classification Ensembles?
Creators: name: Bian, Yijun
name: Chen, Huanhuan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Ensembles, as a widely used and effective technique in the machine learning community, succeed within a key element -- "diversity." The relationship between diversity and generalization, unfortunately, is not entirely understood and remains an open research issue. To reveal the effect of diversity on the generalization of classification ensembles, we investigate three issues on diversity, i.e., the measurement of diversity, the relationship between the proposed diversity and the generalization error, and the utilization of this relationship for ensemble pruning. In the diversity measurement, we measure diversity by error decomposition inspired by regression ensembles, which decomposes the error of classification ensembles into accuracy and diversity. Then we formulate the relationship between the measured diversity and ensemble performance through the theorem of margin and generalization and observe that the generalization error is reduced effectively only when the measured diversity is increased in a few specific ranges, while in other ranges larger diversity is less beneficial to increasing the generalization of an ensemble. Besides, we propose two pruning methods based on diversity management to utilize this relationship, which could increase diversity appropriately and shrink the size of the ensemble without much-decreasing performance. Empirical results validate the reasonableness of the proposed relationship between diversity and ensemble generalization error and the effectiveness of the proposed pruning methods.
description: Accepted by the IEEE Transactions on Cybernetics