cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Die Vegetationsverhältnisse in den Wäldern von Adelegg
Creators: name: Baur, Karl
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
Unsere einheimischen Brillenschötchen (Biscutella)
Creators: name: Bertsch, Karl
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
Über die Verbreitung einiger Pflanzen auf der Ostalb und ihrem Vorland - Nachtrag 1956
Creators: name: Mahler, Karl
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
Zur Verbreitung einiger Gruppen niederer Süßwassertiere in Fließgewässern Nordwürttembergs
Creators: name: Buck, Harald
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
A classified list of surveyed papers from Why are we not evaluating multiple competing hypotheses in ecology and evolution?
Creators: name: Betini, Gustavo S.
name: Avgar, Tal
name: Fryxell, John M.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: The use of multiple working hypotheses to gain strong inference is widely promoted as a means to enhance the effectiveness of scientific investigation. Only 21 of a 100 randomly selected studies from the ecological and evolutionary literature tested more than one hypothesis and only eight tested more than two hypotheses. The surprising rarity of application of multiple working hypotheses suggests that this gap between theory and practice might reflect some fundamental issues. Here, we identify several intellectual biases and practical barriers that discourage us from using multiple hypotheses in our scientific investigation. While scientists have developed a number of ways to avoid biases, such as the use of double-blind controls, we suspect that few scientists are fully aware of the potential influence of cognitive bias on their decisions and they have not yet adopted many techniques available to overcome intellectual and practical barriers in order to improve scientific investigation.
Mollusken und Molluskengesellschaften der Gewässer des Nördlinger Rieses
Creators: name: Häßlein, Ludwig
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
Raumerkundungen in der poetischen Literatur der Hebräischen Bibel. Metaphorische Räume im Ijobbuch und in den Psalmen
Creators: name: Bunzel, Marlen
Year: 2023
Subjects: Alttestamentliche Bibelwissenschaft
Old Testament studies
ÖFOS 2012 -- GEISTESWISSENSCHAFTEN (6) -- Philosophie, Ethik, Religion (603) -- Theologie (6032) -- Alttestamentliche Bibelwissenschaft (603201)
ÖFOS 2012 -- HUMANITIES (6) -- Philosophy, Ethics, Religion (603) -- Theology (6032) -- Old Testament studies (603201)
Metaphorical Space
Body
Relationship with God
Job
Psalms

description: Ausgehend von den Erkenntnissen des Spatial Turns werden in diesem Beitrag drei metaphorische Räume erkundet, die sich in der poetischen Literatur der Hebräischen Bibel finden: der Raum des Todes, der Raum des Körpers und der Raum der Gottesbeziehung. Diese Räume entstehen meist unbewusst beim Lesen. Erst wenn diese Räume bewusst erkundet werden, kann der poetische Text der Hebräischen Bibel (Ijobbuch und Psalmen) seine volle Wirkung entfalten.
Die Invasion des Tannenhähers (Nucifraga Caryocatactes) in Württemberg 1954/55
Creators: name: Heer, Erwin
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
Pre-Analysis Report
Creators: name: Langmaack, Silke
name: Jekel, Marc
name: Herbst, Katharina
name: Huthmacher, Ruth
Publisher: name: OSF Registries
Year: 2018

description: Has the replication crisis an influence on the reporting of p-values?
This work will analyse significant p-values of a set of studies selected from a particular Journal in the field of general psychology by conducting a p-Curve. To answer this question the p-curve of a set of studies belonging to the period before the crisis will be compared with a set of studies belonging to the period after the crisis.
On the cognitive and cultural „enrichment“ of contemporary Europe by immigration.
Creators: name: Rindermann, Heiner
Publisher: name: figshare
Year: 2016
Subjects: Developmental and Educational Psychology

description: Prof. Dr. Heiner RindermannTU Chemnitz, Germany
On the Cognitive and Cultural "Enrichment" of Contemporary Europe by Immigration
Property and Freedom SocietyEleventh Annual MeetingBodrum, 1-6 September 2016
Ist der Rückgang des Weißen Storches durch künstliche Nestanlagen aufzuhalten?
Creators: name: Hornberger, Friedrich
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
SoKonBe: Externe, pädagogisch-psychologische Beratung von Dozenten/innen zur Verbesserung der Lehrqualität mit Fokus auf effektiver Nutzung sozio-kognitiver Konflikte.
Creators: name: Rindermann, Heiner
name: Baumeister, Antonia
name: Bochmann, René
name: Koczielski, Conrad
Publisher: name: figshare
Year: 2016
Subjects: Developmental and Educational Psychology

description: SoKonBe: Externe, pädagogisch-psychologische Beratung von Dozenten/innen zur Verbesserung der Lehrqualität mit Fokus auf effektiver Nutzung sozio-kognitiver Konflikte
Heiner Rindermann, René Bochmann, Antonia Baumeister und Conrad Koczielski (Berlin, 12.09.2016)
Die Lepidopterenfauna von Württmberg. II. Microlepidopteren. Kleinschmetterlingen (7. Fortsetzung)
Creators: name: Wörz, Albert
Publisher: name: - NO PUBLISHER DEFINED -
Year: 1956

description: Jahreshefte des Vereins für Vaterländische Naturkunde in Württemberg : zugl. Jahrbuch d. Staatlichen Museums für Naturkunde in Stuttgart
description: Bd. 111, 1956
Regenerating the live: the archive as the genesis of a performance practice
Creators: name: Dunne, Joseph
Publisher: name: University of Lincoln
Year: 2024
Subjects: W440 - Theatre studies

description: Live performance lacks the durability of art practices such as photography, film andpainting, and so definitions of ‘live’ acts have traditionally been formulated in termsof ‘transience’ and ‘disappearance’. In this context the archive and archival documentsare often described as the antithesis of performance’s ontology. An archive’s primaryfunction is to preserve material for future, undetermined uses, whereas a live event istemporary and cannot endure as ‘itself’ outside of the temporal-spatial zone it unfoldsin before an audience. Yet archival documents are intimately imbricated in thecreation of live acts. This can be seen in all performance practices, from written playsin the dramatic theatre, to the assemblage of materials used in devised performance, tothe ways sites are framed as sources of historical knowledge in performance reenactments.By examining the role documents play in performance practice I arguethat archival materials have the potential to act as the genesis for live acts.The archive’s generative function makes performance a potential method of historicalresearch, where documents can help engender an interactive reciprocity betweenspectators and the past. The archival mode of performance practice I advocate in thisthesis requires spectators to become participants inside the performance sphere, just ashistorians participate in the writing of historical discourses in the archive.There are several practice-as-research components to my project. These include theAudience as Document events and two workshops. The primary practice-as-researchevent is a participatory site-specific performance Voices from the Village. TheOlympic Village in Stratford, East London, is framed as a type of authoritativehistorical document that works as a meta-narrative of London’s past. The OlympicLegacy anchors the memories of East London’s residents to a time they areencouraged to re-live in their everyday lives. At the centre of contemporary urbanregeneration projects is a firm conviction that the future can be built in the here-andnow.Participants are guided through the Village and by two tour guides who attemptto inculcate them into the Legacy Project – a new type of citizenry based upon theneoliberal hegemony. In the third part participants explore what would happen if theneighbouring Hackney Wick estate was ‘regenerated’ in the future. My practice 4examines how documents in performance can act as interlocutors between a site’spast(s) and a participant’s ‘live’ experience. The enduring form of digital documentscreates a manifold afterlife for performance on the Web, which is the home of anevolving network of people who connect to each other through their re-interpretationof the Olympic Legacy. I am arguing that the life of a performance does not end overa fixed duration, but is instead a dialogic process with a multitude of access points.
Advancing Research Assessment with a Focus on Open Science
Creators: name: Tatum, Clifford
name: Di Donato, Francesca
Publisher: name: Zenodo
Year: 2024
Subjects: Open Science
EOSC
CoARA
Research Assessment
Responsible Research Assessment
Horizon Europe

description: Presentation of the GraspOS project at the EOSC-CoARA workshop on 10 April 2024.
Regenerating the live: the archive as the genesis of a performance practice
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: W440 - Theatre studies

description: Live performance lacks the durability of art practices such as photography, film andpainting, and so definitions of ‘live’ acts have traditionally been formulated in termsof ‘transience’ and ‘disappearance’. In this context the archive and archival documentsare often described as the antithesis of performance’s ontology. An archive’s primaryfunction is to preserve material for future, undetermined uses, whereas a live event istemporary and cannot endure as ‘itself’ outside of the temporal-spatial zone it unfoldsin before an audience. Yet archival documents are intimately imbricated in thecreation of live acts. This can be seen in all performance practices, from written playsin the dramatic theatre, to the assemblage of materials used in devised performance, tothe ways sites are framed as sources of historical knowledge in performance reenactments.By examining the role documents play in performance practice I arguethat archival materials have the potential to act as the genesis for live acts.The archive’s generative function makes performance a potential method of historicalresearch, where documents can help engender an interactive reciprocity betweenspectators and the past. The archival mode of performance practice I advocate in thisthesis requires spectators to become participants inside the performance sphere, just ashistorians participate in the writing of historical discourses in the archive.There are several practice-as-research components to my project. These include theAudience as Document events and two workshops. The primary practice-as-researchevent is a participatory site-specific performance Voices from the Village. TheOlympic Village in Stratford, East London, is framed as a type of authoritativehistorical document that works as a meta-narrative of London’s past. The OlympicLegacy anchors the memories of East London’s residents to a time they areencouraged to re-live in their everyday lives. At the centre of contemporary urbanregeneration projects is a firm conviction that the future can be built in the here-andnow.Participants are guided through the Village and by two tour guides who attemptto inculcate them into the Legacy Project – a new type of citizenry based upon theneoliberal hegemony. In the third part participants explore what would happen if theneighbouring Hackney Wick estate was ‘regenerated’ in the future. My practice 4examines how documents in performance can act as interlocutors between a site’spast(s) and a participant’s ‘live’ experience. The enduring form of digital documentscreates a manifold afterlife for performance on the Web, which is the home of anevolving network of people who connect to each other through their re-interpretationof the Olympic Legacy. I am arguing that the life of a performance does not end overa fixed duration, but is instead a dialogic process with a multitude of access points.
Original Source References: Symbiosis limits establishment of legumes outside their native range at a global scale.
Creators: name: Dinnage, Russell
name: Simonsen, Anna
Publisher: name: figshare
Year: 2016
Subjects: subject: 60208 Terrestrial Ecology
subject: FOS: Biological sciences

description: Supplementary file for Symbiosis limits establishment of legumes outside their native range at a global scale. Includes all references from original sources by species. Will probably update this with a more efficiently organized document.
New draft item
Creators: name: Rindermann, Heiner
name: Baumeister, Antonia
name: Bochmann, René
name: Koczielski, Conrad
Publisher: name: figshare
Year: 2016
Subjects: Developmental and Educational Psychology

description: SoKonBe: Externe, pädagogisch-psychologische Beratung von Dozenten/innen zur Verbesserung der Lehrqualität mit Fokus auf effektiver Nutzung sozio-kognitiver Konflikte
Heiner Rindermann, René Bochmann, Antonia Baumeister und Conrad Koczielski (Berlin, 12.09.2016)
Ordonnance du conseil souverain, qui ordonne aux Patrons & Collateurs de tous les Bénéfices situés dans le ressort, de déposer au Greffe les noms & qualités des personnes pourvues desdits Bénéfices, depuis le premier Février 1681, jusqu'à ce jour, pour s'assurer qu’ils n'en ont pas conféré à des Étrangers
Creators: name: Plouvain, Pierre-Antoine-Samuel-Joseph (1754-1832)
name: Six, Philippe-Josse-Auguste-Joseph (1732-1793)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: Rémunération
Institution ecclésiastique
Étranger

description: Source: http://nordnum.univ-lille.fr/ark:/72505/a0115224001360im5Ol/from/a011522400136ypxWl2
description: Coverage: Parlement de Flandre
description: created: 02/10/2018
description: created: 26/03/1683
Pairing Craft-making and Interactivity with Mandarin Learning - How Mobile Devices Can Be Better Used To Help Migrant Preschoolers Maintain Mandarin As Their Heritage Language
Creators: name: Wil-Kie Tan
Publisher: name: Monash University
Year: 2016
Subjects: subject: 130102 Early Childhood Education (excl. Maori)
subject: FOS: Educational sciences

description: The use of Information and Communication Technology (ICT) has become a prevalent aspect in how we learn in schools and at work. For many migrant bilingual ethnic Chinese parents/carers who are concerned about their preschoolers’ learning of Mandarin, they are allowing their children access to Mandarin language applications on mobile devices, in hope that it would be useful to the maintenance of its use at home and within their cultural community. Hence with parents/carers readily cascading mobile technology to the children, they have grown familiar to gesture-based interaction and non-linear navigation on smartphones/tablets. However the effectiveness of solely using mobile devices as a learning tool for preschoolers remains debatable.
 This thesis’s objective is to investigate the potential of formulating a more holistic framework by bridging mobile technologies, relevant socio-cultural theories, appropriate language content and complementary adult-facilitated craft-making. It is hoped that through such a framework it would not only promotes interaction between the adults and their children, but also generates greater interest the reading and use of oral Mandarin. The findings from field activities, using different craft-based design probes adapted from the proposed framework, suggested that the pairing of tangible and onscreen activities has the potential for further development by designers, educators and developers in edutainment content and toy objects. The pairing of co-created craft/toy objects between parents/carers with their preschoolers provides interesting opportunities to integrate the maintenance and transmission of Mandarin with a materially relevant yet imaginative experience.
title: 02_1124
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Hearing voices: How do substances affect the relationship with voices, coping and compliance?
Creators: name: Redstone, Lucy
Publisher: name: University of Lincoln
Year: 2024
Subjects: C800 - Psychology

description: Objectives: The cognitive model offers a useful framework to understand the emotional and behavioural consequences of voice-hearing experience. Substance use can be viewed as a way of coping with these emotional and behavioural consequences. This research explores how substance use as a coping strategy may affect voice-hearers? beliefs about their relationships with the voices, how they cope with the voices and compliance with command hallucinations.Design: This research used a qualitative design to analyse the experiences of participants that have used substances as a way of coping with hearing voices giving commands. Participants were recruited from early intervention services and community mental health services within a local NHS Trust.Methods: Semi-structured interviews were held with nine participants and analysed using a thematic analysis to identify themes amongst the accounts of their experiences. Participants also completed a Beliefs About Voices Questionnaire (BAVQ-R) as a triangulation measure of the appraisals of the voices.Results: Six themes in total were identified during the analysis and a theme of control was interpreted as central to the research question. These themes were: Control; emotional moderation; relationships; self-concept; understanding of psychosis and function of the substance use. Many participants viewed themselves as passively using substances which took control of themselves and their voices. Participants also used substances to disengage from the emotional effect of hearing voicesConclusions: The research suggests that people who hear voices may use substances to lessen the control of the voice. For some this may mean remaining passive and attributing substances (including anti-psychotic medication) as having control over the voice. This has implications for how services can successfully engage individuals in treatment. The effect of substance use on compliance with commands remains unclear.
The Digital Preservation of a Large-scale Collection of Historical Stock Exchange Price Lists - The Credit Lyonnais “ Capital Markets of the World” Collection, 1850­-2000
Creators: name: Schiltz, Michael
Publisher: name: figshare
Year: 2017
Subjects: Digital Humanities

description: The Capital Markets of the World project (hereafter: CMoW) is an attempt to develop the scholarly potential of this comprehensive and unique collection of historical financial information and, simultaneously, to work towards the long-­term sustainable preservation of the latter. Recognizing the fact that accessibility and preservation of the information contained are different, sometimes conflicting, but nevertheless equally important ambitions, the project takes a hybrid approach​. It builds on an analog technology (i.e. microfilm) and a digital one (online description/disclosure in the form of a searchable digital archive). For the production and/or maintenance of both, it employs the expertise of three commercial companies that have been recognized as world leaders in their field.
The Digital Preservation of a Large-scale Collection of Historical Stock Stock Exchange Price Lists - The Credit Lyonnais “ Capital Markets of the World” Collection, 1850­-2000
Creators: name: Schiltz, Michael
Publisher: name: figshare
Year: 2016
Subjects: Digital Humanities

description: The Capital Markets of the World project (hereafter: CMoW) is an attempt to develop the scholarly potential of this comprehensive and unique collection of historical financial information and, simultaneously, to work towards the long-­term sustainable preservation of the latter. Recognizing the fact that accessibility and preservation of the information contained are different, sometimes conflicting, but nevertheless equally important ambitions, the project takes a hybrid approach​. It builds on an analog technology (i.e. microfilm) and a digital one (online description/disclosure in the form of a searchable digital archive). For the production and/or maintenance of both, it employs the expertise of three commercial companies that have been recognized as world leaders in their field.
HotPotatoes for Advanced users - Thinking outside the box
Creators: name: Bogdanov, Stan
Publisher: name: figshare
Year: 2016
Subjects: subject: Computer Software
subject: FOS: Computer and information sciences
subject: 80404 Markup Languages
subject: 80305 Multimedia Programming
subject: 80505 Web Technologies (excl. Web Search)
subject: Language
subject: Linguistics
subject: FOS: Languages and literature

description: 2  December, 2010
Training workshop at New Bulgarian University
Orbicom Report 2007: Emerging Opportunities in SE Asia
Creators: name: Maio, Paola Di
Publisher: name: figshare
Year: 2016
Subjects: subject: 80610 Information Systems Organisation
subject: FOS: Computer and information sciences
subject: Information Systems
subject: 80709 Social and Community Informatics
subject: FOS: Media and communications
subject: 80505 Web Technologies (excl. Web Search)

description: Report about economic opportunities in Digital Technologies
Hearing voices: How do substances affect the relationship with voices, coping and compliance?
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C800 - Psychology

description: Objectives: The cognitive model offers a useful framework to understand the emotional and behavioural consequences of voice-hearing experience. Substance use can be viewed as a way of coping with these emotional and behavioural consequences. This research explores how substance use as a coping strategy may affect voice-hearers? beliefs about their relationships with the voices, how they cope with the voices and compliance with command hallucinations.Design: This research used a qualitative design to analyse the experiences of participants that have used substances as a way of coping with hearing voices giving commands. Participants were recruited from early intervention services and community mental health services within a local NHS Trust.Methods: Semi-structured interviews were held with nine participants and analysed using a thematic analysis to identify themes amongst the accounts of their experiences. Participants also completed a Beliefs About Voices Questionnaire (BAVQ-R) as a triangulation measure of the appraisals of the voices.Results: Six themes in total were identified during the analysis and a theme of control was interpreted as central to the research question. These themes were: Control; emotional moderation; relationships; self-concept; understanding of psychosis and function of the substance use. Many participants viewed themselves as passively using substances which took control of themselves and their voices. Participants also used substances to disengage from the emotional effect of hearing voicesConclusions: The research suggests that people who hear voices may use substances to lessen the control of the voice. For some this may mean remaining passive and attributing substances (including anti-psychotic medication) as having control over the voice. This has implications for how services can successfully engage individuals in treatment. The effect of substance use on compliance with commands remains unclear.
Tannin-based adhesive for protection of colonic anastomosis in the open abdomen
Creators: name: Youming Deng
name: Jianan Ren
name: Guopu Chen
name: Gefei Wang
name: Guosheng Gu
name: Jieshou Li
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy

description: This study was aimed to evaluate the effect of tannin acid- polyethylene glycol (TP) adhesive on the wound healing process of primary colonic anastomosis in the open abdomen (OA). Adhesion strength test, degradation and hemostatic ability of TP were investigated. In a rat model, after standard colonic anastomoses, rats were divided into three groups: OA group; OA + FG (fibrin glue) group; OA + TP group. Five days after surgery, body weight, anastomotic bursting pressure (ABP), and histology of anastomotic tissue were evaluated. Performance of adhesion strength and hemostatic ability of TP was better than that of FG. The weight of TP decreased by over 50% after 11-day incubation. All rats survived well after surgery. Compared to OA group and OA + FG group, OA + TP group showed a significant improvement in body weight, ABP and healing state. Application of TP adhesive, used as an auxiliary treatment of colonic anastomosis operation, improved the wound strength and promoted the anastomotic healing after OA.
Help seeking in adults with anorexia nervosa: what is the role of significant others?
Creators: name: Cox, Samantha Jane
Publisher: name: University of Lincoln
Year: 2024
Subjects: C800 - Psychology

description: Background: The aim of the study was to explore the role of significant others1 in problem disclosure and help seeking in adults with anorexia. Existing literature on help seeking is predominantly focused on anorexia in children and adolescents (Honey & Halse, 2005; Tierney, 2005; Thomson et al. 2014). Anorexia becomes more chronic the longer it is left untreated, and delays in seeking treatment are associated with poorer recovery outcomes (Ficher, Quadflieg & Hedlund, 2006). Therefore, early intervention is key. This study sought to explore an under researched area and map the territory for future projects.Methodology: Participants were recruited from a carer group in the UK for carers of individuals with an eating disorder and B-eat, a charity that supports individuals in the UK with their eating disorder. Ten individuals self-selected to participate in the study and took part in a one retrospective semi structured interview. Interviews were audio recorded and transcribed verbatim. The data was analysed using thematic analysis, following the guidelines by Braun and Clarke (2006).Results: Six superordinate themes were identified: (1) First Response, (2) Confrontation and Confession/Denial, (3) Stepping In, (4) “Stepping Back”, (5) Care Context and (6) Flexible and Persistent Approach.
Help seeking in adults with anorexia nervosa: what is the role of significant others?
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C800 - Psychology

description: Background: The aim of the study was to explore the role of significant others1 in problem disclosure and help seeking in adults with anorexia. Existing literature on help seeking is predominantly focused on anorexia in children and adolescents (Honey & Halse, 2005; Tierney, 2005; Thomson et al. 2014). Anorexia becomes more chronic the longer it is left untreated, and delays in seeking treatment are associated with poorer recovery outcomes (Ficher, Quadflieg & Hedlund, 2006). Therefore, early intervention is key. This study sought to explore an under researched area and map the territory for future projects.Methodology: Participants were recruited from a carer group in the UK for carers of individuals with an eating disorder and B-eat, a charity that supports individuals in the UK with their eating disorder. Ten individuals self-selected to participate in the study and took part in a one retrospective semi structured interview. Interviews were audio recorded and transcribed verbatim. The data was analysed using thematic analysis, following the guidelines by Braun and Clarke (2006).Results: Six superordinate themes were identified: (1) First Response, (2) Confrontation and Confession/Denial, (3) Stepping In, (4) “Stepping Back”, (5) Care Context and (6) Flexible and Persistent Approach.
The Digital Preservation of a Large-scale Collection of Historical Stock Exchange Price Lists - The Credit Lyonnais “ Capital Markets of the World” Collection, 1850­-2000
Creators: name: Schiltz, Michael
Publisher: name: figshare
Year: 2016
Subjects: Digital Humanities

description: The Capital Markets of the World project (hereafter: CMoW) is an attempt to develop the scholarly potential of this comprehensive and unique collection of historical financial information and, simultaneously, to work towards the long-­term sustainable preservation of the latter. Recognizing the fact that accessibility and preservation of the information contained are different, sometimes conflicting, but nevertheless equally important ambitions, the project takes a hybrid approach​. It builds on an analog technology (i.e. microfilm) and a digital one (online description/disclosure in the form of a searchable digital archive). For the production and/or maintenance of both, it employs the expertise of three commercial companies that have been recognized as world leaders in their field.
2007orbicom_emerg_dev_opport.pdf
Creators: name: Maio, Paola Di
Publisher: name: figshare
Year: 2016
Subjects: subject: 80610 Information Systems Organisation
subject: FOS: Computer and information sciences
subject: Information Systems
subject: 80709 Social and Community Informatics
subject: FOS: Media and communications
subject: 80505 Web Technologies (excl. Web Search)

description: Report about economic opportunities in Digital Technologies
Orbicomm Report 2007: Emerging Opportunities in SE Asia
Creators: name: Maio, Paola Di
Publisher: name: figshare
Year: 2016
Subjects: subject: 80610 Information Systems Organisation
subject: FOS: Computer and information sciences
subject: Information Systems
subject: 80709 Social and Community Informatics
subject: FOS: Media and communications
subject: 80505 Web Technologies (excl. Web Search)

description: Report about economic opportunities in Digital Technologies
Galleria mellonella: an in vivo model for accessing the efficacy of colistin in combination with broad spectrum antibiotics against biofilm forming Acinetobacter baumannii infections
Creators: name: Gillett, Alice Rose
Publisher: name: University of Lincoln
Year: 2024
Subjects: C521 - Medical microbiology

description: The emergence of opportunistic nosocomial bacteria Acinetobacter baumannii, which causes infections in critically ill patients with compromised immune systems, is one of the most clinically challenging pathogens to treat effectively.Most nosocomial pathogens grow as monoculture or poly-species biofilms in infections and the biofilm mode of existence for A. baumannii may almost certainly contribute to its increased multi-drug resistant (MDR), although resistance can also be attributed to many contributing factors including overuse and misuse of antibiotics in hospitals and the community.In vitro methods for studying microbial biofilms have developed to include the CDC biofilm reactor, Flow cell devices and MBEC™ but in vivo biofilm model development has been very limited. Few simple animal models are available which reflect either the biofilm nature of growth of pathogens or the treatment of infection influenced by biofilm development in vivo. Biofilm formation is a critical virulence and defence strategy for bacteria, the present study focuses on working towards establishing a biofilm generated in-vivo model to assess the efficacy of antimicrobials against A. baumannii infections.The present study looks at the effects of broad spectrum antibiotics (BSA) and colistin combinations against lethal planktonic or biofilm A. baumannii infections with a pre-clinical insect model, Galleria mellonella (Greater wax moth larvae). The work shows colistin to be an important synergist both in vitro and in a simple in vivo model. This work is the first to describe a model biofilm associated infection in G. mellonella.
Galleria mellonella: an in vivo model for accessing the efficacy of colistin in combination with broad spectrum antibiotics against biofilm forming Acinetobacter baumannii infections
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C521 - Medical microbiology

description: The emergence of opportunistic nosocomial bacteria Acinetobacter baumannii, which causes infections in critically ill patients with compromised immune systems, is one of the most clinically challenging pathogens to treat effectively.Most nosocomial pathogens grow as monoculture or poly-species biofilms in infections and the biofilm mode of existence for A. baumannii may almost certainly contribute to its increased multi-drug resistant (MDR), although resistance can also be attributed to many contributing factors including overuse and misuse of antibiotics in hospitals and the community.In vitro methods for studying microbial biofilms have developed to include the CDC biofilm reactor, Flow cell devices and MBEC™ but in vivo biofilm model development has been very limited. Few simple animal models are available which reflect either the biofilm nature of growth of pathogens or the treatment of infection influenced by biofilm development in vivo. Biofilm formation is a critical virulence and defence strategy for bacteria, the present study focuses on working towards establishing a biofilm generated in-vivo model to assess the efficacy of antimicrobials against A. baumannii infections.The present study looks at the effects of broad spectrum antibiotics (BSA) and colistin combinations against lethal planktonic or biofilm A. baumannii infections with a pre-clinical insect model, Galleria mellonella (Greater wax moth larvae). The work shows colistin to be an important synergist both in vitro and in a simple in vivo model. This work is the first to describe a model biofilm associated infection in G. mellonella.
GDI D8.7 - Report on semantic interoperability scenarios
Creators: name: van der Velde, K.Joeri
name: Swertz, Morris
name: Been, Gerieke
Publisher: name: Zenodo
Year: 2024
Subjects: GDI
European Genomic Data Infrastructure
1+MG
1+Million Genomes Initiative
B1MG
Interoperability scenarios
Semantic

description: The Genomic Data Infrastructure (GDI) project aims to overcome or lower barriers in clinical diagnostics and treatment by facilitating access to fragmented human genomics data across Europe. The project establishes a federated, secure infrastructure, but faces interoperability challenges on all 6 layers of the refined eHealth European Interoperability Framework due to the diversity of implementations of law and regulations, various organisational setups, data sources and infrastructures.

To address this issue, a framework for solving interoperability scenarios is proposed. This framework is able to take on a variety of relevant interoperability building blocks and interoperability scenarios that are listed in this deliverable. Key framework components include shared logical models from which we derive data management systems that serve intrinsically interoperable APIs. These systems are allowed to make different model selections or use different software products while maintaining interoperability.

The main drivers for this work are Genome of Europe (GDI T7.1 and 1+MG WG12), Cancer (GDI T7.4 and 1+MG WG9), Infectious diseases (GDI T7.3 and 1+MG WG11), Rare disease (GDI T7.2 and 1+MG WG8), as well as D7.4, MS26, MS27 from WP7. The framework will support the implementation of the T8.2 semantic interoperability package, which develops and harmonizes the minimal models from the WP7 datasets, and we expect it will contribute to achieving WP3 MS7 and MS8, WP8 T8.3, and D4.3, MS11, and MS12 from WP4. Furthermore, multiple standards for data discoverability from the TEHDAS ‘Recommendations to enhance interoperability’ within HealthData@EU have been incorporated in the reference implementation of the framework, such as Beacon, BBMRI MIABIS and DCAT-AP. The upcoming HealthDCAT-AP standard, built on DCAT-AP and designed specifically for the HealthData@EU infrastructure by WP6 of the EHDS2 Pilot, will be implemented when released. HealthDCAT-AP will standardise the descriptions of health-related datasets in GDI to ensure interoperability with the EHDS and meet the needs of its users.

A reference implementation of this framework MOLGENIS EMX2 has resulted in a data management solution that acts as a data catalogue and as a ‘local portal’ towards the underlying genomics data. It features Beacon v2, FAIR Data Point, RDF, Life Science AAI, integration and synchronisation to a REMS instance for managing data access requests. The catalogue currently contains datasets like the B1MG Rare Disease Synthetic Dataset. The reference implementation is packaged in a Docker container for easy installation and testing, encouraging collaboration and feedback from all GDI partners.
Gene co-expression of mitosis related genes is a stronger indicator of functional engagement than average expression level: a comparison involving high and low proliferating tissues
Creators: name: Reynolds, Beau
Publisher: name: University of Lincoln
Year: 2024
Subjects: C400 - Genetics

description: Genes play a major role in controlling a wide range of biological, physiological and cellular processes. While the regulated level of expression of individual genes is known to play a key role in modulating specific cellular functions, genes however do not act in isolation. Instead, any individual cellular function is the result of a large number of genes acting in close coordination. In this study, we investigate the link between the relative level of gene expression or, alternatively, the level of co-ordination of functionally related genes (co-expression) and the level of demand for their associated biological function. Looking at mitosis genes, as defined by their Gene Ontology categorization, as a reference set of genes, we examined their expression and co-expression across tissue samples known to differ in their cell proliferation demands. Specifically, we looked at expression data from a variety of human-derived tissues including brain-derived samples at several developmental stages. Using microarray data, we compared highly proliferative cell lines with the much less proliferative nervous tissues and found that there was a significant decrease for both average expression and co-expression, of mitosis-associated genes, in line with decreased demand of proliferative functions. Co-expression, however, was a much stronger indicator of functional engagement. The observed contrast is not the result of comparing tumoural tissues with normal tissues as proliferative non-nervous tissues, showed significantly higher co-expression of mitosis genes than in nervous tissues. Using both microarray and RNA sequencing expression data, we compared average expression and co-expression of mitosis genes across pre-natal and post-natal brain-derived samples. In pre-natal development neurogenesis is higher as this is required for early formation of the brain, after birth this function is much less required. Our results show that absolute level of expression did not significantly alter, however co-expression of mitosis-associated genes was once again significantly higher during pre-natal development compared to post-natal stages. Our results show that co-expression is a robust signature of mitotic function requirement with average level of expression representing a less consistent predictor of functional activation. Whether this association between functional engagement and co-expression can be extended to all biological functions should be further investigated.
Gene co-expression of mitosis related genes is a stronger indicator of functional engagement than average expression level: a comparison involving high and low proliferating tissues
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2023
Subjects: C400 - Genetics

description: Genes play a major role in controlling a wide range of biological, physiological and cellular processes. While the regulated level of expression of individual genes is known to play a key role in modulating specific cellular functions, genes however do not act in isolation. Instead, any individual cellular function is the result of a large number of genes acting in close coordination. In this study, we investigate the link between the relative level of gene expression or, alternatively, the level of co-ordination of functionally related genes (co-expression) and the level of demand for their associated biological function. Looking at mitosis genes, as defined by their Gene Ontology categorization, as a reference set of genes, we examined their expression and co-expression across tissue samples known to differ in their cell proliferation demands. Specifically, we looked at expression data from a variety of human-derived tissues including brain-derived samples at several developmental stages. Using microarray data, we compared highly proliferative cell lines with the much less proliferative nervous tissues and found that there was a significant decrease for both average expression and co-expression, of mitosis-associated genes, in line with decreased demand of proliferative functions. Co-expression, however, was a much stronger indicator of functional engagement. The observed contrast is not the result of comparing tumoural tissues with normal tissues as proliferative non-nervous tissues, showed significantly higher co-expression of mitosis genes than in nervous tissues. Using both microarray and RNA sequencing expression data, we compared average expression and co-expression of mitosis genes across pre-natal and post-natal brain-derived samples. In pre-natal development neurogenesis is higher as this is required for early formation of the brain, after birth this function is much less required. Our results show that absolute level of expression did not significantly alter, however co-expression of mitosis-associated genes was once again significantly higher during pre-natal development compared to post-natal stages. Our results show that co-expression is a robust signature of mitotic function requirement with average level of expression representing a less consistent predictor of functional activation. Whether this association between functional engagement and co-expression can be extended to all biological functions should be further investigated.
Neurotensin: a candidate for peptide-guided drug delivery
Creators: name: Bird, Joanna
Publisher: name: University of Lincoln
Year: 2024
Subjects: B200 - Pharmacology, toxicology & pharmacy

description: Modern pharmacotherapy, especially with regards to the treatment of cancer, has been faced with one major obstacle for many years: poor drug specificity. The use of many biotherapeutic/chemotherapeuticdrugs for the treatment of cancer is largely dose-limited due to their highly toxic nature and largely unspecific mode of action, causing 'off target' drug interactions, inadequate drug concentrations at 'on target' areas and poor patient compliance due to the necessity to receive large amounts of a drug that hinder quality of life. Currently available research into the development of recombinant biotherapeutic drugs, targeted to specific ligand receptors, has presented a new mode of drug delivery, which could potentially avoid these problems – drug delivery selective to the tissue of choice with minimal damage to physiologically normal cells. Neurotensin (NT) is a tridecapeptide known to exert a variety of effects on the human body; it has a dual role as both a neuromodulator in the central nervous system and as a local hormone in the periphery. The actions of neurotensin are mediated by specific interactions with one of three neurotensin receptors: NTS1, NTS2 and NTS3, all of which are known to internalise upon interaction with neurotensin. NTS1 in particular is thought to play the biggest role in eliciting the actions of neurotensin and is the main focus of this study; as NTS1 is known to be up regulated in a variety of different cancer types, including pancreatic and breast tumours, it could potentially serve as a target for neurotensin-mediated drug-delivery. The data presented in this study characterises the extent of expression of NTS1 in both polarised and non-polarised Caco-2, and HEK293 cell lines. The uptake and transport of two NT-conjugated fluorophores (GFP and fluorescein) were compared to evaluate the affect of cargo size on cellular uptake. Investigation into uptake and transport of the two fluorophores, elicited by neurotensin, showed both to be internalised in a receptor mediated fashion with the smaller of the two (fluorescein) exhibiting internalisation and transport to a greater extent than the larger (GFP). Visualisation by confocal microscopy showed fluorophore localisation close to the nucleus of the cell. From a more general perspective, this work aims to elucidate the potential for neurotensin to be employed to enhance the delivery of bio-therapeutics to treat 'difficult' cancers, such as pancreatic cancer, which is notorious for poor survival rates and is known to overexpress receptors for neurotensin. If successful, neurotensin-conjugation of bio-therapeutics could improve survival rates by lowering necessary dosages and increasing cancer cell specificity.