BindingDB Entry 50020588: Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: ALK tyrosine kinase receptor, AP2-associated protein kinase 1, Activin receptor type-1, Activin receptor type-2A, Ankyrin repeat and protein kinase domain-containing protein 1, Atrial natriuretic peptide receptor 1, Atypical kinase COQ8A, mitochondrial, Atypical kinase COQ8B, mitochondrial, Cyclin-G-associated kinase, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3, Cyclin-dependent kinase 4, Cyclin-dependent kinase 5, Cyclin-dependent kinase 7, Cyclin-dependent kinase 8, Cyclin-dependent kinase 9, Cytoplasmic tyrosine-protein kinase BMX, Dual specificity protein kinase TTK, Epidermal growth factor receptor, Focal adhesion kinase 1, Hepatocyte growth factor receptor, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase kinase kinase 20, Neuropilin-2, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Platelet-derived growth factor receptor alpha/beta, Proto-oncogene tyrosine-protein kinase ROS, RAC-alpha serine/threonine-protein kinase, RAC-beta serine/threonine-protein kinase, RAC-gamma serine/threonine-protein kinase, RAF proto-oncogene serine/threonine-protein kinase, STE20-like serine/threonine-protein kinase, Serine/threonine-protein kinase 38, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase B-raf, Serine/threonine-protein kinase ICK, Serine/threonine-protein kinase MAK, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase pim-1, Tyrosine-protein kinase Blk, Tyrosine-protein kinase Fgr, Tyrosine-protein kinase HCK, Tyrosine-protein kinase Lck, Vascular endothelial growth factor A, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 3, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein ALK tyrosine kinase receptor, AP2-associated protein kinase 1, Activin receptor type-1, Activin receptor type-2A, Ankyrin repeat and protein kinase domain-containing protein 1, Atrial natriuretic peptide receptor 1, Atypical kinase COQ8A, mitochondrial, Atypical kinase COQ8B, mitochondrial, Cyclin-G-associated kinase, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3, Cyclin-dependent kinase 4, Cyclin-dependent kinase 5, Cyclin-dependent kinase 7, Cyclin-dependent kinase 8, Cyclin-dependent kinase 9, Cytoplasmic tyrosine-protein kinase BMX, Dual specificity protein kinase TTK, Epidermal growth factor receptor, Focal adhesion kinase 1, Hepatocyte growth factor receptor, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase 8, Mitogen-activated protein kinase kinase kinase 20, Neuropilin-2, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Platelet-derived growth factor receptor alpha/beta, Proto-oncogene tyrosine-protein kinase ROS, RAC-alpha serine/threonine-protein kinase, RAC-beta serine/threonine-protein kinase, RAC-gamma serine/threonine-protein kinase, RAF proto-oncogene serine/threonine-protein kinase, STE20-like serine/threonine-protein kinase, Serine/threonine-protein kinase 38, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase B-raf, Serine/threonine-protein kinase ICK, Serine/threonine-protein kinase MAK, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase pim-1, Tyrosine-protein kinase Blk, Tyrosine-protein kinase Fgr, Tyrosine-protein kinase HCK, Tyrosine-protein kinase Lck, Vascular endothelial growth factor A, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 3, Uniprot A0A024R759, O14976, O60462, P00533, P04049, P05622, P06239, P08581, P08631, P08922, P09769, P11309, P11802, P15056, P15692, P16066, P17948, P20794, P24941, P26618, P27037, P27361, P31749, P31751, P33981, P35916, P35968, P42336, P45983, P49336, P50613, P50750, P51451, P51813, P53350, Q00526, Q00535, Q04771, Q05397, Q13043, Q15208, Q2M2I8, Q8NFD2, Q8NI60, Q96D53, Q9H2G2, Q9NYL2, Q9UM73, Q9UPZ9, and Q9Y243