cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optimal treatment strategies to improve medical outcomes for human diseases
Creators: name: Vakil, Vahideh
Publisher: name: No Publisher Supplied
Year: 2022

description: Biological systems are complex, with many interacting subsystems that operate at different functional levels. These different subsystems operate in an interconnected manner, with many complementary functions and redundancies in place to protect the organism from malfunction. Consequently, when a disease arises, it is typically a malfunction of multiple subsystems and thus is a complex phenomenon in its own right. As a result, the treatment of diseases should aim to address the multi-faceted challenges of the disease, rather than treating a single aspect of the disease’s cause. Furthermore, determining drug dosages is critical for achieving optimal therapeutic outcome and conducting clinical tests during the drug development process. By identifying the proper dosages and frequency of administration, dosage algorithms aim to optimize the onset, intensity, and duration of the therapeutic effects of the drugs while minimizing any adverse effects.For these reasons, the objectives of this research, which led to this doctoral dissertation, are proposing solutions to overcome the limitations of the conventional therapeutic approaches, developing mathematical and quantitative techniques to improve medical treatments for human diseases through systems biology, systems pharmacology and systems immunology approaches, as well as supporting public health decisions associated with viral pandemics through epidemiological modeling. In particular, these objectives will be achieved by: • Presenting a comprehensive study on mathematical methods and network medicine techniques that model the interactive behavior of the drug mixture and the target, ultimately allowing one to better predict the outcome of drug combinations with respect to synergism and antagonism, as well as the methods that explore the dynamics of combination therapy and its role in combating drug resistance.• Designing a method for determining an optimal dosage strategy to combat drug resistance in tumor progression, based on a dynamic model for the clonal evolution of cancerous cells, as well as the Pharmacokinetic/Pharmacodynamic (PKPD) model of combination therapy, through solving an optimization problem that minimizes the total number of cancerous cells.• Postponing the emergence of resistance in heterogeneous tumors, by proposing a mathematical framework involving clonal evolution modeling of drug-sensitive and drug-resistant clones and solving an optimal control problem during control phase of therapy in a containment treatment approach.• Proposing a model for the innate and adaptive immune systems in response to SARS-CoV-2 viral infection, modeling within-host dynamics of the novel corona virus and investigating the effectiveness of antiviral treatment on COVID-19.• Modeling the dynamics of COVID-19 transmission through extending classic compartmental models to reflect empirical observations, while considering various vaccination strategies as well as the emergence of new variants.
title: Demographischer Wandel – Wandel der Autowelt
title: Potentiale der ökonomischen Altersproduktivität für den Automobilstandort Deutschland
titleType: AlternativeTitle
Creators: name: Olschewsky, Christin
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: Ökonomische Altersproduktivität
subject: Automobilindustrie
subject: Seniorenwirtschaft
subject: 300
subject: Bevölkerungsentwicklung
subject: Alter
subject: Kraftfahrzeugindustrie |

description: In der Geschichte Deutschlands haben ältere Menschen noch nie so lange gelebt und konnten angesichts einer guten Gesundheit und Einkommenssituation noch nie so lange aktiv am gesellschaftlichen und wirtschaftlichen Leben teilnehmen. Ältere Menschen fühlen sich heute deutlich jünger, als dies ihrem kalendarischen Alter entspricht. Diese Rahmenbedingungen werden von hegemonialen Bildern eines aktiven Alters aufgegriffen, welche in hohem Maße an Mobilität und insbesondere an automobile Mobilität anknüpfen. Einen Führerschein und ein Auto zu besitzen, stellt für ältere Menschen ein Symbol für Freiheit und uneingeschränkte Mobilität dar. Aber es zeichnen sich auch Ambivalenzen ab. Denn die Lebensphase Alter stellt sich differenziert dar und gewährleistet nicht allen älteren Menschen den Genuss eines positiven und (auto)mobilen Alter(n)s. Innerhalb der vorliegenden Arbeit wird einerseits herausgearbeitet, welche Bedeutung automobile Mobilität für eine aktive gesellschaftliche Teilhabe im Alter und damit für eine hohe Lebensqualität hat und andererseits untersucht, wie die Automobilindustrie als bestimmender Wirtschaftszweig in Deutschland den Herausforderungen des demographischen Wandel begegnet. Es wird insbesondere aufgezeigt, wie sich die demographischen Realitäten auf die Märkte und Kunden, die Produktausrichtung und die Belegschaften innerhalb der Automobilindustrie auswirken und welches Potential das Konzept der ökonomischen Altersproduktivität mit den zentralen Ansätzen der Seniorenwirtschaft und der bezahlten Erwerbsarbeit bietet, um innerhalb einer Win-Win-Konstellation einerseits Wirtschaftswachstum und Beschäftigung und andererseits Mobilität und Selbständigkeit im Alter sicherstellen zu können. Ein besonderer Schwerpunkt wird dabei auf die einer dynamischen Entwicklung unterliegenden innovativen Automobil- und Produktionstechnologien gelegt.
Liquid gas phase transition in hypernuclei
Creators: name: Mallik, S.
name: Chaudhuri, G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The fragmentation of excited hypernuclear system formed in heavy ion collisions has been described by the canonical thermodynamical model extended to three component systems. The multiplicity distribution of the fragments has been analyzed in detail and it has been observed that the hyperons have the tendency to get attached to the heavier fragments. Another important observation is the phase coexistence of the hyperons, a phenomenon which is linked to liquid gas phase transition in strange matter.
description: 5 pages, 6 figures
Evaluación clínica y radiográfica de los implantes dentales realizados en la Universidad de Cartagena
Creators: name: Barrios Pérez, Luis Manuel
name: Puello Del Rio, Edwin Jesús
Publisher: name: Universidad de Cartagena
Year: 2018
Subjects: Radiografía dental
Odontología - Evaluación clínica
Odontología - Historia clínica

description: Tesis (Odontólogo). -- Universidad de Cartagena. Facultad de Odontología. Departamento de Investigación, 2018
description: Dentro de esta investigación, se busca evaluar el estado clínico y radiográfico de las rehabilitaciones implantosoportadas realizadas en unidad de implantes de la Universidad de Cartagena
Understanding the mechanism of action of transcriptional inhibitors in breast cancer
Creators: name: Nguyen, Thuy Mai Van
Publisher: name: Imperial College London
Year: 2020

description: Cancer cells frequently feature aberrant transcriptional program that sustain their oncogenic features including growth and progression. In this study, I systematically characterized the super-enhancer landscapes of breast cancer cells and revealed many super-enhancer-associated genes underlying the oncogenic mechanisms of breast cancers. Enhancer profiling also allowed the identification of core transcriptional regulatory circuitries that are maintained by cell line-specific and common transcription factors. These findings identify cancer drivers, such as TOMM20, ABHD11-AS1, some of which have not previously been linked to breast cancer. In addition to transcriptional dysregulation, control of cell cycle progression is often deregulated in cancer. Both transcription and cell cycle control are regulated by cyclin-dependent kinase-7 (CDK7), highlighting the potential of CDK7 inhibitors for cancer treatment. Our laboratory has developed selective CDK7 inhibitors, one of which, ICEC0942, has been progressed to clinical trials. Utilizing genomic and transcriptional studies, I show that ICEC0942 inhibits global Pol II recruitment to gene promoters and gene bodies and consequently the expression of Pol II-directed genes. RNA-sequencing in breast cancer cell lines identified pathways and genes that are especially sensitive to CDK7 inhibition by ICEC0942. Confirmation of the profiling results, together with use of drugs targeting the identified genes, show that CDK7 inhibition by ICEC0942 stimulates p53, resulting in increased expression of p53-responsive genes. I also demonstrated that ICEC0942 synergises with the p53 activator Nutlin-3A, in inhibiting cancer cell growth. Other genes whose expression is particularly sensitive to ICEC0942, highlighted the P-TEFb transcriptional complex. I show that inhibitors of the P-TEFb complex synergise potently with CDK7 inhibitors. Taken together, new insights into the mechanisms by which CDK7 inhibitors, particularly ICEC0942, work to inhibit the growth of cancer cells has identified potential biomarkers and combination drugs. Translation to the clinical setting could aid patient stratification and improve the utility of CDK7 inhibitors in treatment of cancer patients.
Optical and NIR observations of the nearby type Ia supernova SN 2014J
Creators: name: Srivastav, Shubham
name: Ninan, J. P.
name: Kumar, Brajesh
name: Anupama, G. C.
name: Sahu, D. K.
name: Ojha, D. K.
name: Prabhu, T. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Optical and NIR observations of the type Ia supernova SN 2014J in M82 are presented. The observed light curves are found to be similar to normal SNe Ia, with a decline rate parameter $Δm_{15}(B) = 1.08 \pm 0.03$. The supernova reached $B$-band maximum on JD 2456690.14, at an apparent magnitude $m_B(max) = 11.94$. The optical spectra show a red continuum with deep interstellar Na~{\sc i} absorption, but otherwise resemble those of normal SNe Ia. The Si~{\sc ii} $λ6355$ feature indicates a velocity of $\sim 12\,000$ km s$^{-1}$ at $B$-band maximum, which places SN 2014J at the border of the Normal Velocity and High Velocity group of SNe Ia. The velocity evolution of SN 2014J places it in the Low Velocity Gradient subclass, whereas the equivalent widths of Si~{\sc ii} features near $B$-band maximum place it at the border of the Core Normal and Broad Line subclasses of SNe Ia. An analytic model fit to the bolometric light curve indicates that a total of $\sim 1.3$ M$_{\odot}$ was ejected in the explosion, and the ejected $^{56}$Ni mass $M_{Ni} \sim 0.6$ M$_{\odot}$. The low [Fe~{\sc iii}] $\lambda4701$ to [Fe~{\sc ii}] $\lambda5200$ ratio in the nebular spectra of SN 2014J hints towards clumpiness in the ejecta. Optical broadband, linear polarimetric observations of SN 2014J obtained on four epochs indicate an almost constant polarization ($P_{\rm R} \sim$2.7 per cent; $θ$ $\sim$37$^\circ$), which suggests that the polarization signal is of interstellar origin.
description: 16 pages, 21 figures, Accepted for publication in MNRAS
The crowded magnetosphere of the post common envelope binary QS Virginis
Creators: name: Parsons, S. G.
name: Hill, C. A.
name: Marsh, T. R.
name: Gansicke, B. T.
name: Watson, C. A.
name: Steeghs, D.
name: Dhillon, V. S.
name: Littlefair, S. P.
name: Copperwheat, C. M.
name: Schreiber, M. R.
name: Zorotovic, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present high speed photometry and high resolution spectroscopy of the eclipsing post common envelope binary QS Virginis (QS Vir). Our UVES spectra span multiple orbits over more than a year and reveal the presence of several large prominences passing in front of both the M star and its white dwarf companion, allowing us to triangulate their positions. Despite showing small variations on a timescale of days, they persist for more than a year and may last decades. One large prominence extends almost three stellar radii from the M star. Roche tomography reveals that the M star is heavily spotted and that these spots are long-lived and in relatively fixed locations, preferentially found on the hemisphere facing the white dwarf. We also determine precise binary and physical parameters for the system. We find that the 14,220 +/- 350K white dwarf is relatively massive, 0.782 +/- 0.013Ms, and has a radius of 0.01068 +/- 0.00007Rs, consistent with evolutionary models. The tidally distorted M star has a mass of 0.382 +/- 0.006Ms and a radius of 0.381 +/- 0.003Rs, also consistent with evolutionary models. We find that the magnesium absorption line from the white dwarf is broader than expected. This could be due to rotation (implying a spin period of only ~700 seconds), or due to a weak (~100kG) magnetic field, we favour the latter interpretation. Since the M star's radius is still within its Roche lobe and there is no evidence that its over-inflated we conclude that QS Vir is most likely a pre-cataclysmic binary just about to become semi-detached.
description: 20 pages, 20 figures, accepted for publication in MNRAS
Time-resolved protein dynamics using x-ray crystallography and optical spectroscopy
Creators: name: Baxter, James Michael
Publisher: name: Imperial College London
Year: 2021

description: Reversibly switchable fluorescent proteins (RSFPs) switch between a highly and weakly fluorescent state upon photoexcitation. This switching is known to be driven by reversible photoisomerisation and a change in protonation state of the chromophore. However, the exact sequence of events after optical excitation is unclear. In this thesis, time-resolved crystallography and vibrational spectroscopy are used to study the ultrafast dynamics of a new RSFP. Time-resolved serial femtosecond crystallography (TR-SFX) is used to probe the trans/cis reaction and reveals ultrafast sub-Angstrom motions of the chromophore and surrounding hydrogen bonding network. The addition of a stokes pulse (shown to dump the excited state population) increases these displacements and allows assignment of the light-induced signals to a vibrationally excited electronic ground state structure instead of an excited state structure. Temperature analysis of the steady-state switching rates resolves an intermediate ground-state structure using conventional crystallography which supports the TR-SFX assignments. Ultrafast pump-probe vibrational spectroscopy confirms that excited state photoisomerisation occurs (~70 ps), proceeded by rearrangement of a nearby arginine residue (~7 ps) with deprotonation (trans-neutral/cis-anion) occurring between 2 ns - 1 ms. An additional dump pulse is then shown to repress product formation and reforms the ground state, further supporting the structural observations of the pump-dump-probe crystallography measurements. These results improve our understanding of photoswitching in RSFPs and have important implications for structural assignments in future TR-SFX experiments. Time-resolved serial synchrotron crystallography (TR-SSX) is an accessible and emerging technique for studying protein dynamics on millisecond timescales. Here, the trans/cis isomerisation of an RSFP is probed at 10 ms with a range of pump intensities to demonstrate precise control of the cis-state formation yields. The population transfer is resolved crystallographically using quantitative analysis of the occupancy, showing excellent agreement with optical flash-photolysis measurements. The issue of X-ray induced heating, which leads to partial thermal recovery, is also addressed. A temperature increase of 82-112 K is extracted for the fixed-target sample delivery used, which should be accounted for in all future TR-SSX experiments. Finally, the effect of pH on the protonation step is investigated by studying a RSFP mutant with a destabilised ground state conformation. Structural and spectroscopic evidence is presented for a new class of reaction at low pH, involving a cis-neutral/trans-cation isomerisation, in contrasts to the typical cis-anion/trans-neutral reaction at neutral pH. These steady-state observations expand our understanding of acid/base equilibria in the photoreactions of RSFPs.
Representación de los tipos sociales en la novela Chambacú, corral de negros de Manuel Zapata Olivella
Creators: name: Ospino Padilla, Karen Del Carmen
name: Herazo Herrera, Dana
Publisher: name: Universidad de Cartagena
Year: 2015
Subjects: Tipo social
Etopeya (descripción moral)
Prosopografía (descripción física)
Cuadro de costumbre

description: Tesis (Profesional en Lingüística y Literatura) -- Universidad de Cartagena. Facultad de ciencias humanas. Programa de lingüística y literatura
description: En el siguiente trabajo se abordarán las clases de tipos sociales latinoamericanos: los tipos sociales masculinos parásitos, femeninos misóginos, los “acaparadores”, los tipos sociales de modos de vivir que no dan de vivir y los tipos sociales literarios, propuestos en el texto La construcción de tipos sociales en el costumbrismo latinoamericano, de Dorde Cuvardic García (2008). Estos tipos sociales se analizaran a partir de categorías y se personificaran en algunos personajes de la obra Chambacú, corral de negros (1963), del escritor Manuel Zapata Olivella (1920-2004). Destacaremos la categoría de tipo social a la que pertenecen los personajes principales de la obra, describiendo los aspectos físicos (prosopografía) y los aspectos morales (etopeya) que representan los protagonistas. Además, se explicará la relación entre los cuadros de costumbres y las tipologías sociales.
#DearCinderella : an exploration of storytelling on social media
Creators: name: Crow, Zoey Elizabeth
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Social media
Cinderella
Integrated media

description: We live in a world surrounded by social media. According to data.ai’s State of Mobile 2022 report, American spends approximately 4.8 hours a day on their phone, with 7 of every 10 minutes specifically spent on social and photo & video. This is up 30% from 2019 driven in part by the onset of the COVID 19 global pandemic. A recent study by Uswitch found that Americans spent over 1300 hours on social media in 2020, with an average of 297 hours per year, on Instagram alone. People use social platforms to tell stories about their lives and create more polished and filtered versions of themselves. There is even a specific feature on Instagram called Stories, made for people to post photos and videos about their experiences that disappear in 24 hours. We treat these platforms like different spaces or locations. For example, users go to Twitter often for news headlines, and TikTok for to scroll through large amounts of short videos, much like people go to a movie theater for one type of experience and a coffee shop for another. But can social media platforms also be used to tell a fictional narrative story, specifically an adaptation of a well-known fairytale? How can a hybrid in-person and online narrative structure create a communal experience for audiences? This thesis, driven by the rise of remote, online performance during the COVID 19 pandemic, also explores the question of what base elements are required for a classic story to be recognized by reviewing successful revisionist adaptations of well-known fairy tales, specifically a retelling of Cinderella. Drawing from the concept of transmedia storytelling, I investigate these questions by retelling Cinderella across Instagram, Facebook, and Twitter over a week, culminating in a real-world in-person component in Austin, Texas, for local audience members to attend. Once all the events have ended, I will send out an anonymous survey to collect responses, combined with my observations, to gauge the success of this adaptation.
Orbital and physical parameters, and the distance of the eclipsing binary system OGLE-LMC-ECL-25658 in the Large Magellanic Cloud
Creators: name: Elgueta, S. S.
name: Graczyk, D.
name: Gieren, W.
name: Pietrzynski, G.
name: Thompson, I. B.
name: Konorski, P.
name: Pilecki, B.
name: Villanova, S.
name: Udalski, A.
name: Soszynski, I.
name: Suchomska, K.
name: Karczmarek, P.
name: Gorski, M.
name: Wielgorski, P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present an analysis of a new detached eclipsing binary, OGLE-LMC-ECL-25658, in the Large Magellanic Cloud. The system consists of two late G-type giant stars on an eccentric orbit and orbital period of ~200 days. The system shows total eclipses and the components have similar temperatures, making it ideal for a precise distance determination. Using multi-color photometric and high resolution spectroscopic data, we have performed an analysis of light and radial velocity curves simultaneously using the Wilson Devinney code. We derived orbital and physical parameters of the binary with a high precision of < 1 %. The masses and surface metallicities of the components are virtually the same and equal to 2.23 +/- 0.02 M_sun and [Fe/H] = -0.63 +/- 0.10 dex. However their radii and rates of rotation show a distinct trace of differential stellar evolution. The distance to the system was calculated using an infrared calibration between V-band surface brightness and (V-K) color, leading to a distance modulus of (m-M) = 18.452 +/- 0.023 (statistical) +/- 0.046 (systematic). Because OGLE-LMC-ECL-25658 is located relatively far from the LMC barycenter we applied a geometrical correction for its position in the LMC disc using the van der Marel et al. model of the LMC. The resulting barycenter distance to the galaxy is d_LMC = 50.30 +/- 0.53 (stat.) kpc, and is in perfect agreement with the earlier result of Pietrzynski et al.(2013).
description: accepted for publication in the Astronomical Journal
Capacitance sensors for the detection of uranium dioxide precipitation in fluoride-based molten salt reactors
Creators: name: Wieprecht, William Matthew
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Capacitance
Molten salt reactor
Fluoride salt
Precipitation
Uranium dioxide

description: Molten salt reactors (MSRs) fueled with fluoride-based salts possess an inherent risk of developing uranium dioxide precipitation, either from atmospheric contamination during salt processing or the activation and decay of fluorine, which produces oxygen. Concentrations of UO₂ reduce fuel inventory and pose a criticality risk. Limited MSR operations history suggests that additional methods of monitoring for UO₂ precipitation are required. This thesis investigates the potential for capacitive sensors to monitor for UO₂ precipitation. Adapting methods used for monitoring two-phase flow in water and gas systems, two electrode designs were simulated on a Hastelloy-N pipe containing ⁷LiF-BeF₂ fueled with UF₄. Capacitance values were determined against increasing amounts of UO₂ precipitation. The ring electrodes produced a sinusoidal response on the order of 10⁻¹⁰ farads and the concave plate electrodes produced an exponential response on the order of 10⁻¹² farads. This suggested that capacitive sensors are a viable non-destructive testing method for determining precipitation and reducing the risk of criticality accidents in MSRs. A stronger response may be possible by using impedance methods due to significantly elevated values for the dielectric constant of UO₂ at low frequencies and further research into capacitive sensors is encouraged.
Cooperative communications for sleep monitoring in wireless body area networks
Creators: name: Shimly, Samiya
name: Movassaghi, Samaneh
name: Smith, David
Publisher: name: arXiv
Year: 2016
Subjects: subject: Other Computer Science (cs.OH)
subject: FOS: Computer and information sciences

description: This paper investigates the performance of cooperative receive diversity, for the wireless body area network (WBAN) radio channel, compliant with the IEEE 802.15.6 Standard, in the case of monitoring a sleeping person. Extensive WBAN measurements near the 2.4 GHz ISM band were used. Up to 7 dB and 20% improvement for two-hop communications with the use of relays are empirically demonstrated with respect to outage probability and outage duration, with 3-branch cooperative selection combining and 3-branch cooperative switch-and-examine combining.
description: 2 pages, 3 figures, Electronics Letters
Colloidal Microworms Propelling via a Cooperative Hydrodynamic Conveyor Belt
Creators: name: Martinez-Pedrero, Fernando
name: Ortiz-Ambriz, Antonio
name: Pagonabarraga, Ignacio
name: Tierno, Pietro
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study propulsion arising from microscopic colloidal rotors dynamically assembled and driven in a viscous fluid upon application of an elliptically polarized rotating magnetic field. Close to a confining plate, the motion of this self-assembled microscopic worm results from the cooperative flow generated by the spinning particles which act as a hydrodynamic "conveyor belt." Chains of rotors propel faster than individual ones, until reaching a saturation speed at distances where induced-flow additivity vanishes. By combining experiments and theoretical arguments, we elucidate the mechanism of motion and fully characterize the propulsion speed in terms of the field parameters.
An OH(1720 MHz) Maser and a Nonthermal Radio Source in Sgr B2(M): A SNR--Molecular Cloud Interaction Site?
Creators: name: Yusef-Zadeh, F.
name: Cotton, W.
name: Wardle, M.
name: Intema, H.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Sgr B2 is a well-known star forming molecular cloud complex in the Galactic center region showing evidence of high energy activity as traced by the K$α$ neutral FeI line at 6.4 keV, as well as GeV and TeV $γ$-ray emission. Here we present VLA and GMRT observations with respective resolutions of $\approx3.5"\times1.2"$ and 25$"\times25"$ and report the detection of an OH(1720 MHz) maser, with no accompanying OH 1665, 1667 and 1612 MHz maser emission. The maser coincides with a 150 MHz nonthermal radio source in Sgr B2(M). This rare class of OH(1720 MHz) masers or the so-called supernova remnant (SNR) masers, with no main line transitions, trace shocked gas and signal the interaction of an expanding SNR with a molecular cloud. We interpret the 150 MHz radio source as either the site of a SNR -- molecular gas interaction or a wind-wind collision in a massive binary system. The interaction of the molecular cloud and the nonthermal source enhances the cosmic-ray ionization rate, allows the diffusion of cosmic rays into the cloud and produces the variable 6.4 keV line, GeV and TeV $γ$-ray emission from Sgr B2(M). The cosmic ray electron interaction with the gas in the Galactic center can not only explain the measured high values of cosmic ray ionization and heating rates but also contribute to nonthermal bremsstrahlung continuum emission, all of which are consistent with observations.
description: 15 pages, 4 figures, ApJL (in press)
Historia social y económica de Cartago en 1794
Creators: name: Acuña Jimenez, Maury Jose
Publisher: name: Universidad de Cartagena
Year: 2020
Subjects: Historia social, 1974 - Cartago (Valle del Cauca, Colombia)
Historia económica, 1974 - Cartago (Valle del Cauca, Colombia)

description: Tesis (Historiador) -- Universidad de Cartagena. Facultad de Ciencias Humanas. Programa de Historia, 2020
description: La siguiente monografía interpreta la historia desde el punto de vista cuantitativo, y cualitativo con base al manuscrito del impuesto de alcabala de la época del Virreinato de la Nueva Granada. Donde en primera instancia compara, y analiza los precios de los productos tanto en auge como en insípido desarrollo para le economía de finales del siglo XVIII; como visiona la capacidad económica de un comerciante promedio en Cartago en el año de 1794. Mostrando el comportamiento de esta oferta a la hora de abastecer el mercado con respecto a la cantidad, la frecuencia, y el precio de los productos señalados. En el ámbito social se rastrea con fuentes segundarias el rol que cumplieron los comerciantes vecinos de Cartago en su participación con la iglesia, la trata de afrodescendientes, y las revueltas de finales de siglo. Dejando en claro que no solo fueron seres de negocio, sino que además fueron actores sociales que jugaron un papel importante para la formación de la sociedad del Antiguo Régimen.
Approximation schemes for the study of multi-band Gutzwiller wave functions
Creators: name: Bünemann, Jörg
name: Linneweber, Thorben
name: Gebhard, Florian
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The minimum of the Gutzwiller energy functional depends on the number of parameters considered in the variational state. For a three-orbital Hubbard model we find that the frequently used diagonal Ansatz is very accurate in high-symmetry situations. For lower symmetry, induced by a crystal-field splitting or the spin-orbit coupling, the discrepancies in energy between the most general and a diagonal Gutzwiller Ansatz can be quite significant. We discuss approximate schemes that may be employed in multi-band cases where a minimization of the general Gutzwiller energy functional is too demanding numerically.
description: 8 pages, 8 figures
Anaesthetics affect cancer cell biology through cellular signalling and metabolic modulations
Creators: name: Hu, Cong
Publisher: name: Imperial College London
Year: 2021

description: Surgery remains the first-line treatment for most cancer types. However, anaesthetic use during surgery may influence cancer cell biology and hence affect cancer recurrence. The current PhD study project objective is to evaluate the effects of two general anaesthetics, sevoflurane (inhalational) and propofol (intravenous), on cancer cells. This study intends to understand the impact of anaesthetics on cancer recurrence following surgery and ultimately provide the research rationale of clinical study/trials for improving cancer surgical outcomes. Propofol inhibited lung, colonic, renal, and ovarian cancer cell malignancy in a dose- dependent manner through regulating PEDF* and HIF-1α expressions. Propofol also altered the metabolites of lung, colonic, renal, and ovarian cancer cells that inhibited the lung and ovarian cancer cell glucose metabolism. It was demonstrated that propofol inhibited lung cancer cell malignancy through downregulating GLUT1 and MPC1, thus disturbing glucose metabolism. These processes induced the high PEDF expression, which downregulated HIF-1α via the Akt pathways, thus regulated pro- and anti-tumour genes. However, propofol neither inhibited brain cancer cell malignancy nor affected the above molecular entities. In contrast, sevoflurane enhanced colonic, renal and ovarian cancer cell malignancy through upregulating VEGFA. Sevoflurane upregulated GLUT1, MPC1 and GLUD1, which enhanced ovarian cancer cellular glucose metabolism. These changes inhibited PEDF expression, and its reduction resulted in upregulating HIF-1α via the Erk pathway, which upregulated two pro-tumour gene-encoded proteins, namely CXCL12 and CXCR4. However, propofol had the opposite effect on these cellular signalling and metabolic pathways in ovarian cancer cells. In summary, this PhD project demonstrated that sevoflurane may have pro-tumour while propofol might have anti-cancer properties. According to laboratory evidence found in the current study, propofol, unlike sevoflurane, may benefit cancer surgery patients. The work presented in this thesis may provide a foundation for further clinical studies to optimise the anaesthesia regimen for better surgical outcomes following cancer surgery.
A Mutual Information Approach to Calculating Nonlinearity
Creators: name: Smith, Reginald D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: A new method to measure nonlinear dependence between two variables is described using mutual information to analyze the separate linear and nonlinear components of dependence. This technique, which gives an exact value for the proportion of linear dependence, is then compared with another common test for linearity, the Brock, Dechert and Scheinkman (BDS) test.
description: 13 pages, 2 figures
Theologie und Psychologie in der Erforschung der Glaubensentwicklung
Creators: name: Fowler, James W.
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 18 Nr. 6/7 (1982): Concilium: Internationale Zeitschrift für Theologie, Band 18, Heft 6/7
Bibelepik. Perspektiven für die historische Erzählforschung
Creators: name: Becker, Anja
name: Hausmann, Albrecht
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
Blutdurst und Selbstbewusstsein in der altjiddischen Bibelepik. Zur Bearbeitung der Bücher Samuel im frühneuzeitlichen ›Shmuel-bukh‹
Creators: name: Lembke, Astrid
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Beim ›Shmuel-bukh‹, einer frühneuzeitlichen Bearbeitung der Bücher Samuel (erstmals gedruckt 1544), handelt es sich um ein formal wie inhaltlich be­merkenswertes Beispiel altjiddischer Bibelepik. Darin werden antike biblische und außerbiblische Traditionen miteinander kombiniert, aber auch jüdische und nicht­jüdische Stoffe und Erzählweisen sowie heldenepische und romanhafte Register. Auf diese Weise entsteht ein heterogener, intrikat montierter Text, der zunächst seinem jüdichen, schon 1562 aber, nach der Übertragung durch Paulus Aemilius ins Deut­sche, auch einem christlichen Publikum verschiedenartige und attraktive Re­zep­tions- und Identifkationsangebote macht.
description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
Some CAT’s Experiences With Complex Signs
Creators: name: Dietz, Hans M.
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: Zu den größten Herausforderungen für Studienanfänger besonders in nichtmathematischen Studiengängen zählt die mathematische Grundlagenausbildung. Die Ursache dafür liegt sehr oft in unangepassten Studien- und Arbeitsmethoden sowie im mangelnden Verständnis für die „Sprache“ der Mathematik. Zur Unterstützung der Studierenden wurde in der „Mathematik für Wirtschaftswissenschaftler I“, die der Autor seit Jahren an der Universität Paderborn liest, mit „CAT“ ein System gezielter methodischer Instruktionen in die regulären Kurse integriert (Dietz 2013). Der vorliegende Beitrag beleuchtet einige Aspekte von CAT aus semiotischer Perspektive.
»Eine Geschichte von bleibendem Wert, für Mutter und Kind«: Die mittelniederländische Verserzählung ›Van den levene ons heren‹ nach der Utrechter Handschrift 1329
Creators: name: Kienhorst, Hans
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Von etwa 1260/70 bis Mitte des 15. Jahrhunderts war die Verserzählung ›Van den levene ons heren‹ im mittelniederländischen Sprachraum sehr beliebt. Diese Popularität mag mit der einzigartigen Behandlung der Lebensgeschichte Jesu aus den kanonischen und apokryphen Evangelien zusammenhängen, z. B. den Er­zähltechniken, die verwendet werden, um die Zuhörerschaft emotional in das Opfer des Menschensohnes am Kreuz einzubeziehen und die Erfüllung dieses Aktes der Sühne Gottes auf möglichst zeitgemäße und greifbare Weise zu vermitteln, auch in Bezug auf die theatrale Art und Weise, wie die Leidensgeschichte Christi in den da­maligen Passionsspielen in den Vordergrund gerückt wurde. Dass es zuhause im Fa­milienkreis gelesen wurde, lässt sich aus Prolog und Epilog der einzigen vollständig erhaltenen Abschrift dieses gereimten ›Leben Jesu‹ aus dem Jahr 1438 ableiten.
description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
Strukturierte Beschreibung von Reflexionen
Creators: name: Horn, Martin Erik
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2015
Subjects: subject: 510

description: In Lehrbüchern erfolgt die mathematische Darstellung von Reflexionen oft wenig strukturiert, konzeptuell ungeordnet und in vielen Fällen nicht leicht nachvollziehbar. Insbesondere die unterschiedlichen Darstellungen von Operatoren und Operanden (beispielsweise von Operatoren als Reflexionsmatrizen, die auf Vektoren als Operanden einwirken), steht einem tieferen Verständnis von Reflexionen im Wege. Deshalb soll hier eine Möglichkeit aufgezeigt werden, bei der Operatoren und Operanden durch gleichartige mathematische Objekte dargestellt werden. So sollte es keinen Unterschied machen, ob ein Vektor als Operand fungiert und reflektiert wird, oder ob der gleiche Vektor als Repräsentant einer Achse und damit als Operator fungiert, der die Reflexion an dieser Achse vermittelt. In einer konsistenten Beschreibung werden gleiche Größen gleichartig ausgedrückt werden. Die mathematische Sprache, die dies gestattet, wird Geometrische Algebra genannt (Doran & Lasenby 2003).
Theodoros Prodromos’ ›Tetrasticha‹. Biblische Handlung als dichte Beschreibung
Creators: name: Hölzlhammer, Lilli
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Der byzantinische Dichter Theodoros Prodromos (ca. 1100–1156/58) er­zählt in seinen ›Tetrasticha‹ die Handlung des Alten und Neuen Testaments in einer zwischen epischem Erzählen und Epigrammdichtung changierenden Form nach. Ziel des Beitrags ist, die ›Tetrasticha‹ in ihrer narrativen Komplexität und als kultu­relles Zeitzeugnis darzustellen. Die ›Tetrasticha‹ spielen mit Textsorten, Zeitebenen, Erzählperspektiven und mit dem in Byzanz üblichen Einweben homerischer Motive und Zitate. Gleichzeitig bieten sie im Sinne von Clifford Geertz dichter Beschreibung Einblick in byzantinische Verhaltensnormen und Denkmuster sowohl hinischtlich des dich­te­rischen Selbstverständnisses als auch gesellschaftlicher Rand­gruppen wie Frauen, Prostituierte und Personen mit Behinderungen oder in gleichgeschlecht­lichen Be­ziehungen
description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
Avas Jesus. Zur Figur des Heilands im ›Leben Jesu‹ der ersten deutschen Dichterin
Creators: name: Becker, Anja
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Der Beitrag stellt heraus, dass Ava im ›Leben Jesu‹ ihren Protagonisten als Figur des Widerspruchs inszeniert. Mittels expliziter auktorialer Charakteri­sie­rungen wird Jesu Doppelnatur als wahrer Gott und wahrer Mensch fokussiert und in ihrer logisch-sachlichen Unvereinbarkeit ausgestellt. Die Szenen­auswahl der Dichterin trägt insofern zur impliziten Figurenzeichnung bei, als sie den Heiland als Frauen, besonders Sünderinnen, in besonderer Weise zugewandt präsentiert. Über sein Dialogverhalten charakterisiert sich Jesus zudem implizit selbst als Figur des Einspruchs, wobei die spezifische Form seines Widerspruchs auf die radikale Alterität des Protagonisten verweist
description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
»Et en sainte escriture ice lisant trovon«: Readers and Reading Practices of the ›Bible‹ in Romance (c.1150) by Herman de Valenciennes
Creators: name: Hoogvliet, Margriet
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Modern researchers are often puzzled that Herman de Valenciennes used twelve-foot verse for his translation of the Bible into the Romance vernacular dating from c.1150, instead of prose, because they perceive an opposition between the sacred text and the chosen form, that of profane epic narrative. This article will argue that verse narrative was regularly used for hagiographic texts, as well as for adaptations of the Bible, both in the Romance vernacular and in Latin. Furthermore, a close reading of Herman’s ›Bible‹ will show that the translator intended to guide his readers towards a correct interpretation of the biblical text and that he anticipated specific reading practices: discontinuous and following the annual cycle of the liturgy and Divine Office, communal and performative, probably including para-liturgical practices by singing voice.
description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
Erzähler, Figuren und Gott. Die ›Alethia‹ des Claudius Marius Victorius als Beispiel für Nutzen und Grenzen narratologischer Kategorien
Creators: name: Kuhn-Treichel, Thomas
Publisher: name: Beiträge zur mediävistischen Erzählforschung
Year: 2023

description: Die ›Alethia‹ des Claudius Marius Victorius (5. Jh.) enthält Ausdrucksweisen, die man narratologisch als Vermischungen diegetischer Ebenen und damit teilweise als Metalepsen beschreiben kann, so wenn der Erzähler Figuren in der 2. Person apostrophiert oder sich durch eine 1. Person Plural logikwidrig mit ihnen assoziiert. In vielen dieser Fälle spielt zusätzlich zum Erzähler und den Figuren Gott eine Rolle, und dies erschwert eine narratologische Deutung, weil Gott sich einer Zuordnung zu einer diegetischen Ebene entzieht. Gerade diese Schwierigkeiten einer narratologischen Deutung erweisen sich jedoch als erhellend für die besonderen Mechanismen der Gattung Bibelepik.
description: Beiträge zur mediävistischen Erzählforschung, 2023: Bibelepik. Mediävistische Perspektiven auf eine europäische Erzähltradition
Lipofilización del almidón nativo de yuca dulce y agria (Manihot esculenta) y evaluación de su posible uso como agentes emulsificantes en formulaciones alimentarias
Creators: name: Marrugo Paola, Gina Rebeca
name: Álvarez Meza, Paola Belén
Publisher: name: Universidad de Cartagena
Year: 2014
Subjects: Almidón agrio de yuca
Almidon de yuca
Industria alimentaria

description: Tesis (Ingeniero de Alimentos).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería de Alimentos, 2014
description: El objetivo del proyecto fue evaluar la capacidad emulsificante del almidón nativo de yuca (Manihot esculenta); como valor agregado se trabajó también con yuca agria (Manihot esculenta); así mismo se mejoró la capacidad lipofílica, introduciendo a las cadenas poliméricas constitutivas de los almidones (amilosa y amilopectina), cadenas carbonadas, que aumenten su afinidad por los aceites.
Systematizing FAIR research data management in biomedical research projects: a data life cycle approach
Creators: name: Emam, Ibrahim
Publisher: name: Imperial College London
Year: 2020

description: Biomedical researchers are facing data management challenges brought by a new generation of data driven by the advent of translational medicine research. These challenges are further complicated by the recent calls for data re-use and long-term stewardship spearheaded by the FAIR principles initiative. As a result, there is an increasingly wide-spread recognition that advancing biomedical science is becoming dependent on the application of data science to manage and utilize highly diverse and complex data in ways that give it context, meaning, and longevity beyond its initial purpose. However, current methods and practices in biomedical informatics remain to adopt a traditional linear view of the informatics process (collect, store and analyse); focusing primarily on the challenges in data integration and analysis, which are challenges only pertaining to a part of the overall life cycle of research data. The aim of this research is to facilitate the adoption and integration of data management practices into the research life cycle of biomedical projects, thus improving their capabilities into solving data management-related challenges that they face throughout the course of their research work. To achieve this aim, this thesis takes a data life cycle approach to define and develop a systematic methodology and framework towards the systematization of FAIR data management in biomedical research projects. The overarching contribution of this research is the provision of a data-state life cycle model for research data management in Biomedical Translational Research Projects. This model provides insight into the dynamics between 1) the purpose of a research-driven data use case, 2) the data requirements that renders data in a state fit for purpose, 3) the data management functions that prepare and act upon data and 4) the resulting state of data that is _t to serve the use case. This insight led to the development of a FAIR data management framework, which is another contribution of this thesis. This framework provides data managers the groundwork, including the data models, resources and capabilities, needed to build a FAIR data management environment to manage data during the operational stages of a biomedical research project. An exemplary implementation of this architecture (PlatformTM) was developed and validated by real-world research datasets produced by collaborative research programs funded by the Innovative Medicine Initiative (IMI) BioVacSafe 1 , eTRIKS 2 and FAIRplus 3.
The random $k$ cycle walk on the symmetric group
Creators: name: Hough, Bob
Publisher: name: arXiv
Year: 2016
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We study the random walk on the symmetric group $S_n$ generated by the conjugacy class of cycles of length $k$. We show that the convergence to uniform measure of this walk has a cut-off in total variation distance after $\frac{n}{k} log n$ steps, uniformly in $k = o(n)$ as $n \to \infty$. The analysis follows from a new asymptotic estimation of the characters of the symmetric group evaluated at cycles.
description: This paper first appeared as part of the author's PhD thesis
[50] Solution of Extended Multi-Objective Portfolio Selection Problem in Uncertain Environment Using Weighted Tchebycheff Method.
Creators: name: KUMAR, PAVAN
Publisher: name: figshare
Year: 2023
Subjects: Operations research
Applied mathematics not elsewhere classified

description: In this paper, a mathematical model for an extended multi-objective portfolio selection (EMOPS) problem is explored with liquidity considered as another objective function besides the risk and return. The model is mathematically formulated in an uncertain environment. The concerned uncertainty is dealt with by employing the fuzzy numbers in the risk matrix and return. While the fuzzy EMOPS model is converted into the corresponding deterministic case based on the a—level sets of the fuzzy numbers, a weighted Tchebycheff method is implemented by defining relative weights and ideal targets. The merit of the suggested method is the applicability in many real-world situations. At the end, some numerical illustration is exhibited for the utility of the suggested EMOPS problem. Finally, it is concluded that the suggested method is simple to learn and to implement in real-life situations for the decision maker.
Prime divisors and the number of conjugacy classes of finite groups
Creators: name: Keller, Thomas Michael
name: Moretó, Alexander
Publisher: name: arXiv
Year: 2023
Subjects: subject: Group Theory (math.GR)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We prove that there exists a universal constant $D$ such that if $p$ is a prime divisor of the index of the Fitting subgroup of a finite group $G$, then the number of conjugacy classes of G is at least $Dp/log_2 p$. We conjecture that we can take $D=1$ and prove that for solvable groups, we can take $D=1/3$.
description: To appear in Math. Proc. Cambridge Philos. Soc