cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
How Patterns of Craniofacial Variation Are Driven by Genetic Variation
Creators: name: Aponte, Jose David
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Education--Health
subject: Genetics
subject: FOS: Biological sciences

description: Craniofacial shape is extraordinarily diverse and highly heritable in humans. We often feel an intuition from facial presentation that allows us to guess the ethnicity, sex, and even syndromic conditions of people we see every day. These aspects of facial shape likely have a strong genetic basis, although it has proven difficult to elucidate exactly which genes contribute to this variation that we intuitively understand. This dissertation aims to better understand why it can be so difficult to unravel the genetic underpinnings of facial shape variation. It starts with an interactive atlas of syndromic facial shape that allows a user to visualize the range of craniofacial phenotypes observed in over 80 congenital syndromes across ages, sexes, and severities. I then delve into how well syndromes can be classified from measurements of facial shape using machine learning. The challenges in classifying syndromes then directly led me to compare non- syndromic and syndromic facial shape to test how morphologically and genetically unique craniofacial phenotypes can be. Finally, I turned to mice to compare the craniofacial variation associated with groups of genes to the craniofacial variation produced in mouse mutants of large effect. These studies in humans and mice have shown substantial overlap in morphology between non-syndromic and syndromic facial variation, suggesting that facial variation operates in a limited scope of dimensionality. Importantly, that variation has a quantifiable genomic basis that suggests that many developmental pathways jointly contribute to the patterns of craniofacial variation that we observe.
Differential impact of single and binary metal mixtures on membrane biophysics as determined by fluorescence and nuclear magnetic resonance spectroscopy
Creators: name: Lewrenz, Anna-Marie
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Biophysical Chemistry
subject: Lipid Biochemistry
subject: Metal Toxicology
subject: Biochemistry

description: Heavy metals are toxic to bacterial and eukaryotic organisms. In humans, they are associated with Alzheimer's disease and various cancers. Metals like gadolinium, cadmium, lead, and mercury can bioaccumulate. Lipids are a known metal target in biomembranes. Although metal-lipid interactions have been studied, interactions of metal mixtures are not well understood. This study of binary mixtures of Gd, Cd, and Pb addresses their impact on membrane fluidity and phase transition from rigid gel to fluid liquid-crystalline phases by using fluorescence spectroscopy, in particular Laurdan generalized polarization (GP). Laurdan GP results showed that Gd with its 3+ charge outcompeted the effects of Cd and Pb and induced the largest rigidification. Binary mixtures of Hg/Cd or Pb/Cd showed a higher affinity of Hg and Pb for chloride than Cd. It is known that under physiological conditions some inorganic metals form chloro-complexes. Speciation was considered by using 113Cd, 199Hg, nuclear magnetic resonance. Mixtures of Pb, Cd, and Hg were examined to determine whether their speciation were similar to calculated speciation. Lastly, the Hg induced cleavage of a specific lipid class, plasmalogens was known without a detailed understanding of the mechanism. 1H and 13C nuclear magnetic resonance were used but more work is needed to determine the final step of the mechanism. These studies investigated potential contributions of metal toxicity at the membrane level for bioaccumulating metals of concern, but also included the impact of metal mixtures, which has not been sufficiently investigated in the field.
Community Help for Inclusive Learning and Development (CHILD): A Study of How Mobile Phones Were Used to Recruit and Equip Community Volunteers to Support Children’s Learning During Covid-19 School Closures in Zimbabwe.
Creators: name: Power, Tom
name: Buckler, Alison
name: Ebubedike, Margaret
name: Tengenesha, martha
name: Jama, Mbuso
name: Ndlovu, America
name: Mukoyi, Jane
name: Mubaira, Simbarashe
Publisher: name: The Open University
Year: 2021
Subjects: subject: 130306 Educational Technology and Computing
subject: FOS: Educational sciences
subject: Education
subject: 130101 Continuing and Community Education
subject: 130199 Education systems not elsewhere classified

description: By mid-March 2020, 107 governments around the world had instructed schools to close their doors to learners, still more closed clusters of schools in particular areas. Record numbers of children found themselves ‘out of school’. UNESCO predicts ‘devastating’ impacts from long-term disruption to education.

While many technology-centred initiatives were launched in response to Covid school closures, an equitable educational response must recognise that in low and middle-income countries most of these ‘out of school’ children are offline. In Sub-Saharan Africa, most disadvantaged children will not have access to TV or radio to continue their learning. How then to design alternative arrangements for girls’ learning and to maintain children’s identity as learners?

In this paper, we explore how a collective sense of responsibility for education was activated and supported in remote communities in Zimbabwe, and how this re-shaped local understanding of educational practices. We examine the experiences of those involved to address the overarching research question: ‘In the context of pandemic disease and widespread school closures across Sub-Saharan Africa, how can young people in disadvantaged rural communities be supported, locally and from a distance, to maintain engagement in educational activities?’
Is the LHC Observing the Pseudo-scalar State of a Two-Higgs Doublet Model ?
Creators: name: Burdman, Gustavo
name: Haluch, Carlos
name: Matheus, Ricardo
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The ATLAS and CMS collaborations have recently shown data suggesting the presence of a Higgs boson in the vicinity of 125 GeV. We show that a two-Higgs doublet model spectrum, with the pseudo-scalar state being the lightest, could be responsible for the diphoton signal events. In this model, the other scalars are considerably heavier and are not excluded by the current LHC data. If this assumption is correct, future LHC data should show a strengthening of the $γγ$ signal, while the signals in the $ZZ^{(*)}\to 4\ell $ and $WW^{(*)}\to 2\ell 2ν$ channels should diminish and eventually disappear, due to the absence of diboson tree-level couplings of the CP-odd state. The heavier CP-even neutral scalars can now decay into channels involving the CP-odd light scalar which, together with their larger masses, allow them to avoid the existing bounds on Higgs searches. We suggest additional signals to confirm this scenario at the LHC, in the decay channels of the heavier scalars into $AA$ and $AZ$. Finally, this inverted two-Higgs doublet spectrum is characteristic in models where fermion condensation leads to electroweak symmetry breaking. We show that in these theories it is possible to obtain the observed diphoton signal at or somewhat above of the prediction for the standard model Higgs for the typical values of the parameters predicted.
description: 6 pages, 5 figures, final version in Physical Review D
title: A Longitudinal Seroepidemiology Study to Evaluate Antibody Response to SARS-CoV-2 Virus and Vaccination in Children in Calgary, Canada from July 2020 to September 2022.
title: AB3C
titleType: AlternativeTitle
Creators: name: Doucette, Emily Jayne
name: Kellner, James Duncan
Publisher: name: Canadian Immunization Conference
Year: 2023
Subjects: COVID-19
antibodies
pediatrics
vaccine
serology

description: Funded by Government of Alberta and Alberta Children's Hospital Research Institute.
description: Introduction: Measurement of SARS-CoV-2 antibody seropositivity is important to accurately understand exposure to infection and/or vaccination in populations. Methods: A cohort of children with or without prior SARS-CoV-2 infections was enrolled in Calgary, Canada in 2020. Venous blood was sampled 4 times from July 2020 to April 2022 for SARS-CoV-2 nucleocapsid and spike antibodies, with an additional 5th visit in the fall of 2022. Demographic and clinical information was obtained including SARS-CoV-2 test results and vaccination records. Results and analysis: 1035 children were enrolled and 88.9% completed 4 visits; median age 9 years (IQR: 5,13); 519 (50.1%) female; and 815 (78.7%) Caucasian. 477 (46.1%) participants attended Visit 5. Before enrollment, 118 (11.4%) had confirmed or probable SARS-CoV-2 infection. By September 2022, the total cumulative percentage of previously uninfected participants diagnosed with COVID-19 was 53.9% by Visit 5. (0/917 (0%), 15/873 (1.7%), 31/837 (3.7%), 280/820 (34.1%), and 63/439 (14.4%) at Visits 1-5, respectively). Nucleocapsid antibody seropositivity declined to 18.0% after more than 200 days after diagnosis. In contrast, spike antibodies remained elevated in 97.6% of unvaccinated children after more than 400 days after diagnosis. By September 2022, 97.1% (232/239) of children 12 years and older, 85.9% (171/199) of children 5-11, and 15.4% (6/39) of children under 5 received at least 1 dose of vaccine. At that time, all 409 vaccinated children had spike antibodies, compared with 38/64 (59.4%) of unvaccinated children (P<0.001 for comparison of proportions). Conclusions: By September 2022, most children in the study had a serologic response against the SARS-CoV-2 virus from infection and/or vaccination, with unvaccinated children much less likely to have a serologic response. Ongoing studies of serologic status are needed to estimate population levels of virus exposure and durability of antibody response after infection and/or vaccination.
Community Help for Inclusive Learning and Development (CHILD): A Study of How Mobile Phones Were Used to Recruit and Equip Community Volunteers to Support Children’s Learning During Covid-19 School Closures in Zimbabwe.
Creators: name: Power, Tom
name: Buckler, Alison
name: Ebubedike, Margaret
name: Tengenesha, martha
name: Jama, Mbuso
name: Ndlovu, America
name: Mukoyi, Jane
name: Mubaira, Simbarashe
Publisher: name: The Open University
Year: 2021
Subjects: subject: 130306 Educational Technology and Computing
subject: FOS: Educational sciences
subject: Education
subject: 130101 Continuing and Community Education
subject: 130199 Education systems not elsewhere classified

description: By mid-March 2020, 107 governments around the world had instructed schools to close their doors to learners, still more closed clusters of schools in particular areas. Record numbers of children found themselves ‘out of school’. UNESCO predicts ‘devastating’ impacts from long-term disruption to education.

While many technology-centred initiatives were launched in response to Covid school closures, an equitable educational response must recognise that in low and middle-income countries most of these ‘out of school’ children are offline. In Sub-Saharan Africa, most disadvantaged children will not have access to TV or radio to continue their learning. How then to design alternative arrangements for girls’ learning and to maintain children’s identity as learners?

CHILD Research Report
In this paper, we explore how a collective sense of responsibility for education was activated and supported in remote communities in Zimbabwe, and how this re-shaped local understanding of educational practices. We examine the experiences of those involved to address the overarching research question: ‘In the context of pandemic disease and widespread school closures across Sub-Saharan Africa, how can young people in disadvantaged rural communities be supported, locally and from a distance, to maintain engagement in educational activities?’
Interpreting LHC Higgs Results from Natural New Physics Perspective
Creators: name: Carmi, Dean
name: Falkowski, Adam
name: Kuflik, Eric
name: Volansky, Tomer
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We analyze the 2011 LHC Higgs data in the context of simplified new physics models addressing the naturalness problem. These models are expected to contain new particles with sizable couplings to the Higgs boson, which can easily modify the Higgs production cross sections and branching fractions. We focus on searches in the Higgs to 4 leptons and Higgs to diphoton channels, in the latter case including the vector boson fusion production mode. Combining the available ATLAS and CMS data in these channels, we derive constraints on an effective low-energy theory of the Higgs boson. We then map several simplified scenarios to the effective theory, capturing numerous natural new physics models such as supersymmetry and Little Higgs, and extract the constraints on the corresponding parameter space. We show that simple models where one fermionic or one scalar partner is responsible for stabilizing the Higgs potential are already constrained in a non-trivial way by LHC Higgs data.
description: 26 pages, 9 figures; v2: small changes in the analysis, figures and typos fixed, references added; v3: plots and discussion updated
Ontwerprichtlijnen voor het eToP systeem
Creators: name: van der Bie, J.H.F.
name: Bondietti, Sergio
name: de Boer, R.M.
name: Flierman, Monique
name: Bossen, D.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2021
Subjects: subject: Health Sciences
subject: 10 Technology
subject: Information and Computing Sciences

description: Dit document geeft middels ontwerprichtlijnen antwoord op de vraag; “Op wat voor manier kunnen ouders van het ToP programma digitaal ondersteund worden door zorgprofessionals om (thuis) zelfstandig (betrouwbare) informatie te vinden die helpt bij het begeleiden van de ontwikkeling van hun prematuur geboren kind?”

Voor het beantwoorden van deze vraag zijn interviews en focusgroepen gehouden met zorgprofessionals en ouders. Deze interviews zijn geanalyseerd en verwerkt tot ontwerprichtlijnen van een systeem dat ouders kan ondersteunen in het zelfstandig vinden van betrouwbare informatie. De ontwerprichtlijnen bestaan uit een doelgroepomschrijving, lijst van eisen, systeem diagram en interface concepten.

Deze richtlijnen kunnen doorontwikkeld worden naar een prototype platform.
Improving the health of Indigenous peoples: Exploring patient health complexity among urban Indigenous patients in Canada
Creators: name: Sehgal, Anika
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Health Sciences

description: Patient complexity is deemed to arise from a combination of personal, social, and external factors that can complicate medical approaches to care. Formal tools called patient complexity assessment tools (PCATs) have been developed to help identify and address these factors. However, current PCATs are not inclusive of the unique determinants of health impacting Indigenous peoples, including those which arise from a legacy of colonialism. The current thesis aimed to address this gap by identifying the domains and components that should be included in a PCAT designed specifically for Indigenous patients. The first study of this thesis was a scoping review that explored the extent to which existing PCATs are inclusive of the realities that shape the health of Indigenous peoples. Findings identified a major gap in the capacity of existing PCATs to effectively address the realities that shape the health of Indigenous patients. The second study of this thesis was a qualitative study that explored how health complexity is experienced by urban Indigenous peoples and the contexts that allow health complexity to persist. Findings revealed material resource disparities and adverse interpersonal interactions within the healthcare environment to be sources of health complexity. The third study of this thesis aimed to determine the critical components that are indicative of health complexity among Indigenous patients. An Indigenous-centered patient complexity assessment framework was developed to serve as a source of reference for healthcare providers, and policy/decision makers. This thesis presents a framework to understand the root causes of health complexity among Indigenous patients, identify where there may be gaps in healthcare systems to effectively address complexity, and provide reference for future clinical tools that will assess complexity among Indigenous patients.
title: La Plateforme de Lomé : un plaidoyer porté par le mouvement mutualiste
Creators: name: Kanga-Tona, T.
Publisher: name: Médecine Tropicale et Santé Internationale - magazine
Year: 2021

description: L’adoption de la Plateforme d’Abidjan en 1999 a accompagné l’essor des mutuelles de santé sur le continent africain. Vingt ans après l’adoption de la Plateforme d’Abidjan, les mutuelles de santé ont effectivement connu un développement, une structuration ainsi qu’une professionnalisation certains. En janvier 2019, le mouvement mutualiste international a adopté au cours de la conférence de Lomé la « Plateforme de Lomé », un document présentant un nouveau consensus de développement de la mutualité, prenant en compte l’impact des niveaux de décisions nationaux, régionaux et internationaux sur l’environnement influençant le développement des mutuelles de santé. Deux ans après l’adoption du document, ses préconisations restent pertinentes et la crise de la COVID-19 révèle l’importance qu’il y a à se saisir de toutes les ressources afin de développer les systèmes de santé sur le continent africain.
description: Médecine Tropicale et Santé Internationale - magazine, No 1 (2021): MTSI-Magazine
Martin Gardner's minimum no-3-in-a-line problem
Creators: name: Cooper, Alec S.
name: Pikhurko, Oleg
name: Schmitt, John R.
name: Warrington, Gregory S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05D99 (Primary) 00A08 (Secondary)

description: In Martin Gardner's October, 1976 Mathematical Games column in Scientific American, he posed the following problem: "What is the smallest number of [queens] you can put on a board of side n such that no [queen] can be added without creating three in a row, a column, or a diagonal?" We use the Combinatorial Nullstellensatz to prove that this number is at least n, except in the case when n is congruent to 3 modulo 4, in which case one less may suffice. A second, more elementary proof is also offered in the case that n is even.
description: 11 pages; lower bound in main theorem corrected to n-1 (from n) in the case of n congruent to 3 mod 4, minor edits, added journal reference
Exploring Connections between Commensal Bacteria, Metabolites and Small Intestine Stromal Cells using ‘Omics Approaches
Creators: name: Brown, Kirsty
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Microbiome
subject: Metabolomics
subject: Stromal Cells
subject: Lymphatics
subject: Small Intestine
subject: Interleukin-33
subject: Single Cell Sequencing
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Bioinformatics
subject: FOS: Computer and information sciences

description: The intestine is colonized by a complex community of bacteria, termed the intestinal microbiota, that have considerable effects on intestinal immunity. One mechanism by which the microbiota influences the host is by altering the complement of metabolites that are available to the host. Stromal cells, inclusive of lymphatic endothelial cells (LEC) and mesenchymal stromal cells (MSC), support immune responses by providing structural support and direct signals to immune cells. Despite established microbiota-immune and stromal-immune interactions, how the microbiota influences intestinal MSC (iMSC) and LEC is not well defined. This thesis was driven by the hypothesis that bacteria-induced metabolites influence the development and regulation of intestinal stromal cells. To assess this, we profiled metabolites in the intestinal tract, serum, peritoneal fluid, liver, spleen and urine of germ-free (GF), gnotobiotic and specific-pathogen-free (SPF) mice. We analyzed metabolites in weanling and adult mice and male and female mice. This revealed the relative impact of microbiota, age and sex on metabolism and highlighted cases where microbial-induced metabolites were dependent on age and sex. We found that colonization impacts the structure and function of intestinal lymphatics by performing in vivo lipid transport assays and whole mount imaging of small intestine tissues. By performing single cell RNA and ATAC sequencing, we uncover 4 main subclusters of iMSC: FB1, FB2, telocytes and myocytes. We found that all subclusters were present in GF and SPF mice, however there was an expansion of telocytes and contraction of FB2 in female SPF mice compared to GF. We uncover subset-specific regulation of genes relating to epithelial, immune and extracellular matrix deposition and found that myocytes were particularly responsive to the microbiota. In response to microbial colonization, myocytes upregulate interleukin-33 (IL33), potentially through epigenetic modification. Finally, ablation of IL33 in iMSC decreases tissue Il33 levels in the jejunum and increase inflammatory tone, suggesting that iMSC-derived IL33 is a regulator of tissue homeostasis. Collectively, this thesis contributes to our understanding of how microbes regulate metabolism and how the microbiota affects the structure and function of stromal cells in the intestine. This information could be leveraged to develop stromal-based therapies to maintain intestinal health.
Genomic and Virulence Profiling of Erysipelothrix rhusiopathiae Isolated from Widespread Muskox Mortalities in Arctic Archipelago
Creators: name: Seru, Lakshmi Vineesha
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Arctic
subject: muskoxen
subject: mortality
subject: Erysipelothrix rhusiopathiae
subject: virulence genes
subject: pathogenicity islands
subject: prophages
subject: pan-genome wide association studies
subject: Veterinary Science

description: Muskoxen are an important food and economic resource for the indigenous people in the Canadian Arctic; however, in recent years this species has experienced substantial disease-related population declines. A single strain (‘Arctic clone’) of Erysipelothrix rhusiopathiae was associated with mass mortalities of muskoxen on Banks and Victoria Islands in 2010-2013, and various wild species on Prince Patrick Island in 2017. In 2021, an outbreak of E. rhusiopathiae was reported for the first time in muskoxen on Ellesmere Island. The predominance of the Arctic clone in the Arctic raises the question of virulence of this lineage. Objectives of this study were to characterize E. rhusiopathiae isolates from Ellesmere Island and identify amino acid sequence variations among 17 virulence genes, pathogenicity islands and prophages among 28 Arctic clone and 31 other closely related E. rhusiopathiae genomes. In addition, unique genetic contents of the Arctic clone that may encode virulence traits were determined via pan-genome wide association studies. Comparison of virulence gene sequences among 59 E. rhusiopathiae genomes offered insights into amino acid variations unique to the Arctic clone. I found that 16 of 17 virulence genes investigated were present and 4 of 17 were highly conserved among all the genomes. Putative virulence gene sequences of adhesin, rhusiopathiae surface protein-A, choline binding protein-B and leucine rich repeat protein had amino acid sequence variants unique to the Arctic clone. These genes encoded proteins that help E. rhusiopathiae to attach to the host endothelial cells and form biofilms. Characterizing pathogenicity islands revealed a novel finding of 12/28 Arctic clone isolates harbouring toxin-B. Toxin-B is an exotoxin produced by Clostridiodes difficile and causes pathogenesis via cytolysis. None of the prophages harboured virulence genes. The core genome alignment of 59 E. rhusiopathiae whole genomes provided evidence that the Arctic clone might be associated with the mortality on Ellesmere Island. The newly isolated E. rhusiopathiae belong to the Arctic clone, which was found to contain unique amino acid sequences for known virulence genes. The Arctic clone may have gained new virulence traits via mobile genetic elements mediated.
Engaging the state : urban citizenship practices at the frontier of urban renewal and Nagar Raj in suburban Mumbai
Creators: name: Menezes, Benita Maria
Publisher: name: University of British Columbia
Year: 2013

description: What are the political practices of engaging the state at the intersection of urban renewal and decentralization of governance (Nagar Raj) in millennial Mumbai? At stake in this question is the need to intervene in existing scholarship, which, until now, has been framed predominantly through macro-narratives of the structural dimensions of urban change. With regard to urban renewal, it has framed debates through the tropes of gentrification and dispossession and, with regard to urban governmentality, through binary constructs of civil and political society, or the overarching notion of civic governmentality. Although these conceptualizations have been useful, what is missing is a grounded reading of the micro-politics of everyday citizen practices that point to a dynamic and contentious public sphere. This thesis explores the micro-politics of spatial and institutional restructuring in a suburban neighborhood in Mumbai. Drawing on research across the themes of urban decentralization, renewal and citizenship, the research renders more complex the binary constructs of civil/political society as well as the homogeneous categories of urban poor and community by focusing on a case study of neighborhood-led micro-urban renewal. The research locates the evolving political consciousness and agency of neighborhood actors through their actual practices that overlap with and transgress siloed conceptualizations. In developing this argument on the new politics of neighborhoods, four ways of engaging the state in suburban Mumbai are identified: a politics of (1) difference, (2) silence, (3) civility, and (4) compensation.
The Development of Equine Assisted Psychotherapy: A Grounded Theory Study
Creators: name: Stares, Rebecca
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: equine assisted psychotherapy
subject: mental health
subject: adult education
subject: clinical practice
subject: Education--Adult and Continuing
subject: Mental Health
subject: Social Work
subject: FOS: Sociology

description: As the complexity, frequency, and severity of mental health disorders increases across the nation, Canadians are increasingly seeking out psychotherapeutic interventions. Equine assisted psychotherapy is one such intervention. Equine assisted psychotherapy is a collaborative, relationship-focused, intervention which concentrates on the client’s experiences within the human-equine relationship which forms within the therapeutic session with their clinical practitioner. To provide equine assisted psychotherapy, clinical practitioners must engage in continuing education to ensure their practice is safe, effective, and evidence informed. In this qualitative study, a constructivist grounded theory approach was used to generate a theory of equine assisted psychotherapy, Stable Foundations, and from it, explore the approaches through which clinical practitioners may learn equine assisted psychotherapy for the treatment of individuals affected by mental health disorders. Snowball and theoretical sampling were used to recruit 12 participants, nine of which were clinical practitioners utilizing equine assisted psychotherapy in their practice. Of these, five were also facilitators of continuing education into equine assisted psychotherapy. The additional three participants were equine professionals. All participants contributed through semi-structured interviews. Data collection and analysis was iterative. The core category emerging from the analysis and coding was Stable Foundation. It has six categories safety, consent, scope of practice, facilitated relationships, equine knowledge, and qualities of the clinical practitioners. In the construction of the theory, four categories emerged from the data speaking to the teaching and learning of clinical practitioners seeking to utilize equine assisted psychotherapy. These were continuing education, experiential learning, practice and application, and supervision and consultation. In developing a theory of equine assisted psychotherapy and speaking to the educational needs of clinical practitioners, equine assisted psychotherapy can be standardized for replication among interprofessional clinicians and potentially ensure that a minimum standard of learning is achieved. This will benefit the client who will receive a clinically appropriate and effective mental health intervention; clinicians will learn, practice, and supervise equine assisted psychotherapy using best practices; and horses participating in equine assisted psychotherapy will receive ethical and appropriate care.
Работы у с.Золотое
Creators: name: В. Н., Корпусова
name: Орлов, Руслан
name: Я. П., Гершкович
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 430101
subject: Archaeological science

description: Корпусова В.Н., Орлов Р.С., Гершкович Я. Работы у с.Золотое — Археологические открытия 1973 года. - М., Наука, 1974, с.291-293.Works in the village of Zolote
Analysis of Flow and Heat Transfer in OTSGs and Injection Wells
Creators: name: Sivagnanam, Mohan
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Steam Generation
subject: OTSG
subject: Fouling
subject: Perturbation
subject: Thermocouple Shield
subject: Stem Injection
subject: FCD
subject: Engineering--Petroleum

description: Steam for enhanced oil recovery, generated by using once-through steam generators (OTSGs), is injected into extra heavy oil (bitumen) bearing formations to raise the temperature of the oil within. At elevated temperatures, the oil mobility is raised enabling it to be produced to surface. To improve the performance of steam-based processes, the research documented here focuses on two components of the process. The first component is steam generation in OTSGs and the second is injection of steam into the reservoir. More specifically, in the first component, the impact of foulant is examined and how a deliberate flow perturbation can be used to delay the onset of foulant. In the second component, steam flows through slotted liners and flow control devices are investigated. The results show that the thicker the foulant, the higher the outer tube wall temperature and the lower is the water temperature – the foulant acts as an insulator on the inner wall of the tube. Flow perturbations are demonstrated to yield benefits for lowering the outer tube wall temperature. An examination of thermocouples used to measure the temperature of the tube surface in OTSGs is also presented. Simulation results for a thermocouple welded on an OTSG tube showed a discrepancy between the actual temperature and the thermocouple measurement. The use of a radiation shield is shown to provide a better estimate of the bare tube temperature. The analysis of a slotted liner shows that the slot area plays a crucial role in flow distribution within the well and reservoir. Supersonic flow in flow control devices is strongly dependent on steam quality and some of the systems examined exhibited a condensation shock and shock diamonds with exit velocity greater than the inlet. A longer diffuser is shown to minimize the impact of shock waves on the exit velocity.
Convergence of latent mixing measures in finite and infinite mixture models
Creators: name: Nguyen, XuanLong
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistics Theory (math.ST)
subject: Machine Learning (stat.ML)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: This paper studies convergence behavior of latent mixing measures that arise in finite and infinite mixture models, using transportation distances (i.e., Wasserstein metrics). The relationship between Wasserstein distances on the space of mixing measures and f-divergence functionals such as Hellinger and Kullback-Leibler distances on the space of mixture distributions is investigated in detail using various identifiability conditions. Convergence in Wasserstein metrics for discrete measures implies convergence of individual atoms that provide support for the measures, thereby providing a natural interpretation of convergence of clusters in clustering applications where mixture models are typically employed. Convergence rates of posterior distributions for latent mixing measures are established, for both finite mixtures of multivariate distributions and infinite mixtures based on the Dirichlet process.
description: Published in at http://dx.doi.org/10.1214/12-AOS1065 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Factsheet rapportage ouderen en beweging
Creators: name: Kanis, A.M.
name: Nauta, B.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2021
Subjects: subject: Health Sciences
subject: Information and Computing Sciences
subject: 16 Studies in Human Society
subject: 10 Technology

description: This document (in Dutch) reports various facts with regard to elderly people's preferences, hindrances and (digital) interventions with regard to (tailored) physical exercise. It also considers the Covid-19 situation.
What can we learn from corona times? Fragments from the Internet
Creators: name: Kanis, A.M.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2021
Subjects: subject: Engineering
subject: Health Sciences
subject: Humanities
subject: FOS: Humanities
subject: Information and Computing Sciences
subject: 20 Language, Communication and Culture
subject: Meta Science
subject: Psychology
subject: FOS: Psychology
subject: Social Science
subject: 19 Studies in Creative Arts and Writing
subject: 16 Studies in Human Society
subject: 10 Technology
subject: Uncategorised

description: What can we learn from corona times? is a collection of on-line fragments and illustrations from the Internet. It covers a wide range of themes in relation to the period of Covid-19, such as tools for online creativity and remote collaboration, digital suggestions for exercise and social distancing by design.
Multitasking associative networks
Creators: name: Agliari, Elena
name: Barra, Adriano
name: Galluzzi, Andrea
name: Guerra, Francesco
name: Moauro, Francesco
Publisher: name: arXiv
Year: 2011
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We introduce a bipartite, diluted and frustrated, network as a sparse restricted Boltzman machine and we show its thermodynamical equivalence to an associative working memory able to retrieve multiple patterns in parallel without falling into spurious states typical of classical neural networks. We focus on systems processing in parallel a finite (up to logarithmic growth in the volume) amount of patterns, mirroring the low-level storage of standard Amit-Gutfreund-Sompolinsky theory. Results obtained trough statistical mechanics, signal-to-noise technique and Monte Carlo simulations are overall in perfect agreement and carry interesting biological insights. Indeed, these associative networks pave new perspectives in the understanding of multitasking features expressed by complex systems, e.g. neural and immune networks.
description: to appear on Phys.Rev.Lett
Lessons learned from co-creating a personal wayfinding app with people with a visual impairment
Creators: name: van der Bie, J.H.F.
name: Jaschinski, Christina
name: Ben Allouch, S.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2021
Subjects: subject: 10 Technology
subject: Health Sciences

description: Travelling independently in an urban environment is challenging for people with a visual impairment (PVI). Current Wayfinding-apps lack detailed environmental information and are often not fully accessible. With the aim to design a wayfinding solution that facilitates independent travel and incorporates PVI needs and wishes, we deployed a cocreation design approach with PVI and professionals as co-creators. Our combination of different co-creation techniques and iterative prototyping expands the related research on wayfinding solutions and allowed us to zoom-in on specific features. Our approach started with a userrequirements analysis through selfexperience sessions, observations and focus groups. This was followed by iterative prototyping with user evaluations in controlled indoor and outdoor environments. Over a period of two years we created an accessible wayfinding solution in co-creation with 31 PVI and 19 professionals. This resulted in an optimized accessible interface, a personalized route, personalized wayfinding instructions and detailed orientation and environmental information. Lessons learned for co- design with PVI included setting up an accessible workshop environment, applying diverse evaluation methods and involving reoccurring participants.
Additional file 1 of The prognostic value and immune landscaps of m6A/m5C-related lncRNAs signature in the low grade glioma
Creators: name: Li, Ran
name: Chen, Haiyan
name: Li, Chaoxi
name: Qi, Yiwei
name: Zhao, Kai
name: Wang, Junwen
name: You, Chao
name: Huang, Haohao
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Supplemental Figures.
Supermembrane origin of type II gauged supergravities in 9D
Creators: name: del Moral, M. P. Garcia
name: Pena, J. M.
name: Restuccia, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The M-theory origin of the IIB gauged supergravities in nine dimensions, classified according to the inequivalent classes of monodromy, is shown to exactly corresponds to the global description of the supermembrane with central charges. The global description is a realization of the sculpting mechanism of gauging (arXiv:1107.3255) and it is associated to particular deformation of fibrations. The supermembrane with central charges may be formulated in terms of sections on symplectic torus bundles with SL(2,Z) monodromy. This global formulation corresponds to the gauging of the abelian subgroups of SL(2,Z) associated to monodromies acting on the target torus. We show the existence of the trombone symmetry in the supermembrane formulated as a non-linear realization of the SL(2,Z) symmetry and construct its gauging in terms of the supermembrane formulated on an inequivalent class of symplectic torus fibration. The supermembrane also exhibits invariance under T-duality and we find the explicit T-duality transformation. It has a natural interpretation in terms of the cohomology of the base manifold and the homology of the target torus. We conjecture that this construction also holds for the IIA origin of gauged supergravities in 9D such that the supermembrane becomes the origin of all type II supergravities in 9D. The geometric structure of the symplectic torus bundle goes beyond the classification on conjugated classes of SL(2,Z). It depends on the elements of the coinvariant group associated to the monodromy group. The possible values of the (p,q) charges on a given symplectic torus bundle are restricted to the corresponding equivalence class defining the element of the coinvariant group.
description: 41 pages, Latex. Typos corrected, references added, appendix added. Sections enlarged with more examples and clarifying explanations. Minor corrections in section 8. Results unchanged
The asymptotic density of Wecken maps on surfaces with boundary
Creators: name: Kim, Seung Won
name: Staecker, P. Christopher
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 55M20, 37C20

description: The Nielsen number $N(f)$ is a lower bound for the minimal number of fixed points among maps homotopic to $f$. When these numbers are equal, the map is called Wecken. A recent paper by Brimley, Griisser, Miller, and the second author investigates the abundance of Wecken maps on surfaces with boundary, and shows that the set of Wecken maps has nonzero asymptotic density. We extend the previous results as follows: When the fundamental group is free with rank $n$, we give a lower bound on the density of the Wecken maps which depends on $n$. This lower bound improves on the bounds given in the previous paper, and approaches 1 as $n$ increases. Thus the proportion of Wecken maps approaches 1 for large $n$. In this sense (for large $n$) the known examples of non-Wecken maps represent exceptional, rather than typical, behavior for maps on surfaces with boundary.
description: final version
Investigating T Cell Exhaustion in Multiple Myeloma
Creators: name: Barakat, Elie
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Oncology

description: Multiple Myeloma (MM) is a currently incurable malignancy of plasma cells. Immunotherapies are widely agreed upon to be the most likely avenue through which a cure could be found, however, to become longer lasting, permanent solutions, immunotherapies must overcome persistent antigenic stimulation and immune exhaustion. To this end, there is no currently agreed upon immune signature that denotes which cells are exhausted, and which are healthy. The aim of this thesis was to define this exhaustion signature, using only surface antigens and flow cytometry, in order to sort these exhausted T cells from peripheral blood mononuclear cells (PBMC). Based upon the logic that patients who respond poorly to immunotherapy will have on average more exhausted T cells than patients who respond well to immunotherapy, this project developed and optimized a flow cytometry panel designed to use 14 different T cell markers to phenotypically characterize T cells isolated from patient bone marrow aspirates (BMA). While this project did not succeed in generating a full exhaustion signature due to issues concerning censorship within the cohort which shrunk the sample size, it does show that a repetition of this experiment could elucidate the exhaustion signature with a larger sample size and slight adjustments to the antibody panel. An exhaustion signature for T cells can be generated, using surface markers that can be used for flow cytometric sorting in the future.
Quantum Information Processing and Relativistic Quantum Fields
Creators: name: Benincasa, Dionigi M. T.
name: Borsten, Leron
name: Buck, Michel
name: Dowker, Fay
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences
subject: 81P15

description: It is shown that an ideal measurement of a one-particle wave packet state of a relativistic quantum field in Minkowski spacetime enables superluminal signalling. The result holds for a measurement that takes place over an intervention region in spacetime whose extent in time in some frame is longer than the light-crossing time of the packet in that frame. Moreover, these results are shown to apply not only to ideal measurements but also to unitary transformations that rotate two orthogonal one-particle states into each other. In light of these observations, possible restrictions on the allowed types of intervention are considered. A more physical approach to such questions is to construct explicit models of the interventions as interactions between the field and other quantum systems such as detectors. The prototypical Unruh-DeWitt detector couples to the field operator itself and so most likely respects relativistic causality. On the other hand, detector models which couple to a finite set of frequencies of field modes are shown to lead to superluminal signalling. Such detectors do, however, provide successful phenomenological models of atom-qubits interacting with quantum fields in a cavity but are valid only on time scales many orders of magnitude larger than the light-crossing time of the cavity.
description: 16 pages, 2 figures. Improved abstract and discussion of 'ideal' measurements. References to previous work added
Alcune osservazioni sull’istituto del divorzio in Corea del Sud
Creators: name: Losurdo, Raffaella
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Diritto ecclesiastico comparato e straniero

description: Il contributo, sottoposto a valutazione, è destinato alla pubblicazione a stampa negli Annali della Facoltà di Giurisprudenza di Taranto, per i tipi della Casa editrice Cacucci di Bari.
SOMMARIO: 1. Introduzione - 2. La disciplina del divorzio nel Codice Civile coreano e i relativi aspetti patrimoniali - 3. Fidanzamento, matrimonio, nullità e interruzione per morte del matrimonio - 4. La tutela dei figli nel divorzio - 5. Riforma del diritto di famiglia n. 7427/2005
ABSTRACT: Some remarks on divorce in South Korea The Korean family law regulates two different procedures for divorce: divorce by agreement (which is used in cases where both spouses are agree to terminate the marriage) and judicial divorce. Closely related to divorce are different problems, because of which this institution has been repeatedly the subject of reforms; the most significant reforms are: the first one in 1991, which aims to achieve a way of equality between man and woman, then in 2005, which had as its goal to remove the "head of the family" system and the last one in 2007 made to realize an effective protection of children as the greatest victims of their parents’ divorce. The most innovative reform has been the law n. 7427 of 2 March 2005 (with eight points, four of which came into force immediately and the other in 2008). It deals essentially in abolish the head of the family system, on the ground that it was unconstitutional, because the system contains articles that infringe individual dignity and equality between sexes in marriage and so they are contrary to art. 36 of the Korean Constitution.
PAROLE CHIAVE: Codice Civile coreano – Matrimonio - Divorzio – Tutela dei figli – Diritto di famiglia – Leggi di riforma
description: Stato, Chiese e pluralismo confessionale, 2012: 5 novembre
Multi-Lepton Collider Signatures of Heavy Dirac and Majorana Neutrinos
Creators: name: Chen, Chien-Yi
name: Dev, P. S. Bhupal
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the possibility of observing multi-lepton signals at the Large Hadron Collider (LHC) from the production and decay of heavy Standard Model (SM) singlet neutrinos added in extensions of SM to explain the observed light neutrino masses by seesaw mechanism. In particular, we analyze two `smoking gun' signals depending on the Dirac or Majorana nature of the heavy neutrino: (i) for Majorana case, the same-sign di-lepton signal which can be used as a probe of lepton-number violation, and (ii) for Dirac case, the tri-lepton signal which conserves lepton number but may violate lepton flavor. Within a minimal Left-Right symmetric framework in which these additional neutrino states arise naturally, we find that in both cases, the signals can be identified with virtually no background beyond a TeV, and the heavy gauge boson W_R can be discovered in this process. This analysis also provides a direct way to probe the nature of seesaw physics involving the SM singlets at TeV scale, and in particular, to distinguish type-I seesaw with purely Majorana heavy neutrinos from inverse seesaw with pseudo-Dirac counterparts.
description: 19 pages, 7 figures; typo in eq. 5 fixed; matches published version