cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice
Creators: name: Schoppa, Astrid M.
name: Chen, Xiangxu
name: Ramge, Jan-Moritz
name: Vikman, Anna
name: Fischer, Verena
name: Haffner-Luntzer, Melanie
name: Riegger, Jana
name: Tuckermann, Jan Peter Gottfried
name: Scharffetter-Kochanek, Karin
name: Ignatius, Anita
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Skeletal aging
subject: Osteoporosis
subject: Mitochondrial dysfunction
subject: Reactive oxygen species
subject: Senescence
subject: MESENCHYMAL STEM-CELLS
subject: OXIDATIVE STRESS
subject: BONE-FORMATION
subject: MOUSE MODELS
subject: DIFFERENTIATION
subject: REGULATOR
subject: FOXO1
subject: ROS
subject: DDC 610 / Medicine & health

description: Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) and arises in the aging organism, is considered one of the critical factors contributing to osteoporosis. Mitochondrial (mt)ROS, as the superoxide anion (O2−) generated during mitochondrial respiration, are eliminated in the young organism by antioxidant defense mechanisms, including superoxide dismutase 2 (SOD2), the expression and activity of which are decreased in aging mesenchymal progenitor cells, accompanied by increased mtROS production. Using a mouse model of osteoblast lineage cells with Sod2 deficiency, we observed significant bone loss in trabecular and cortical bones accompanied by decreased osteoblast activity, increased adipocyte accumulation in the bone marrow and augmented osteoclast activity, suggestive of altered mesenchymal progenitor cell differentiation and osteoclastogenesis. Furthermore, osteoblast senescence was increased. To date, there are only a few studies suggesting a causal association between mtROS and cellular senescence in tissue in vivo. Targeting SOD2 to improve redox homeostasis could represent a potential therapeutic strategy for maintaining bone health during aging.
Naming or Shaming? Presentations of the Self in Specialised Weblog Discourse
Creators: name: Chapman, Richard
Publisher: name: Iperstoria
Year: 2019

description: During examination of data from a small, specialised corpus, unexpected elements were identified inviting further analysis. Characteristic instances of naming behaviour were observed, prompting deeper investigation into this aspect of web discourse. A corpus of around 100,000 tokens was assembled over a single day in 2014 by collecting contributions to a weblog discussion of the Israel-Palestine conflict. Research aims were to observe linguistic behaviour over a limited timescale and involving a specific, highly controversial topic. Examination of methodological issues concerned with small corpora and how they should be interrogated was a secondary aim. Data were analysed quantitatively and qualitatively, with a stated intention from the outset to employ a hands-on approach as much as possible. Various problems emerged, the most suggestive being employment of names and highly pragmatic discourse features in curious ways. A rereading of data concentrating on names, other forms of self-presentation, and attempts to impose identities on others, suggested a need for discourse-level analysis of linguistic behaviour in weblogs, since naming devices often appear as phrases rather than individual words (although they present as a single token with no spaces) and presuppose a textual environment, pragmatic interpretation and a form of dialogue.
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Imperial Crises and British Political Ideology in the Age of the American Revolution, 1763-1773
Creators: name: Gilding, Ben Joseph
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Britain
Politics
Empire
Colonial
America
East India Company
Debt
Ideology
Imperial Policies
American Revolution
Bengal
Westminster
Parliament

description: The Seven Years’ War and the resulting Treaty of Paris of 1763 represent a watershed in British domestic and imperial histories. Not only did the war result in Britain acquiring vast new territories and rights in North America and South Asia, but it also saddled Britain with a national debt of over £140,000,000. The challenge for British politicians in the post-1763 era was not only finding a balance between the need to secure territorial gains while searching for a means to reduce costs and raise revenues to pay down the debt, but rather to do so without infringing on the constitutional rights of colonists and chartered companies. The political ramifications of the Treaty of Paris were equally important. Disputes over the terms of the Peace tore apart the Newcastle-Pitt coalition, resulting in the dissolution of the Whig Broadbottom. With the Duke of Newcastle and his allies in opposition alongside William Pitt, the political situation was thrown into turmoil. Although the confused state of politics in the short-term undoubtedly resulted in an opposition which acted, as Namier suggested, on the basis of self-interest rather than on principles, it can also be said to have provided the matrix within which historians can observe the genesis of new policies of domestic and imperial governance. It was precisely the lack of ideological identification in politics at the accession of George III that allowed British political ideologies in the age of the American Revolution to so quickly develop alongside the formulation and implementation of, as well as in the opposition responses to, the new challenges facing British parliamentarians in the governance of the Empire. This work therefore traces the development of distinct imperial ideologies among British politicians as they emerged in response to the various imperial crises of the 1760s and 1770s. Additionally, it will be shown that the new and unprecedented crises in both American and Indian affairs were brought about primarily as a means of obtaining revenues for the Treasury. The interrelated nature of the imperial problems in the east and the west, as well as the attempts of British politicians to resolve them, will be examined primarily through the policies made surrounding the article of tea.
The Use of Powerpoint Presentations in Academic English in the Soft Sciences
Creators: name: Costa, Francesca
Publisher: name: Iperstoria
Year: 2019

description: The Power Point programme (PPT) is increasingly used by academics for their presentations. Despite this fact, there have been few linguistic studies that have dealt with PPT, especially as regards the Soft Sciences. The present explorative study seeks to qualitatively investigate the use of PPT by using as terms of comparison universities and conferences, the use of PPT by native speakers as opposed to non-native ones, and the use of PPT in disciplines such as psychology and pedagogy, adopting several parameters present in the literature to see whether there are differences among these elements and, if so, of what kind. The corpus consists of 566 slides, and the results shed light on this type of digital genre, which takes on unique features when used in the Soft Sciences.
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Me, us and it: Insiders views of the complex technical, organisational and personal elements in using virtual worlds in education
Creators: name: Gregory, Sue
name: Gregory, Brent
name: Wood, Denise
name: Grant, Scott
name: Nikolic, Sasha
name: Hillier, Mathew
name: Hearns, Merle
name: Jacka, Lisa
name: McDonald, Marcus
name: Reiners, Torsten
name: Lierse, Sharon
name: John, Blooma
name: Sukunesan, Suku
name: Rutherford, Emily
name: Jegathesan, Jay Jay
name: Butler, Des
name: Farley, Helen
name: Irwin, Pauletta
Publisher: name: Swinburne
Year: 2024

description: The adoption and pedagogical use of technologies such as virtual worlds to support teaching and learning, and research in higher education involves a complex interplay of technical, organisational and personal factors. In this paper, eighteen educators and researchers provide an overview of how they perceive a virtual world can be used in education from the perspective of themselves as individuals ‘me’, their educational organisations and as members of the Australian and New Zealand Virtual Worlds Working Group (VWWG) community of practice ‘us’, as well as the complex technology that underpins this learning environment ‘IT’. Drawing on Linstone’s (1981, 1984) Technical, Organisational and Personal (TOP) multiple perspective concept as the framework for analysis, the authors discuss their perspectives of how the personal, organisational and technical aspects of teaching through the use of virtual worlds have impacted on their teaching and research in higher education. The potential of employing the TOP framework to inform future research into the use of technologies such as virtual worlds in teaching and learning is explored.
Repression meets responsibility: Canadian penal governance in the 'age of transformation'
Creators: name: Groulx, Gordon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Political Science, Public Administration.
subject: Sociology, Criminology and Penology.

description: In December 2007, the Ministry of Public Safety published the Report of the Correctional Service of Canada Panel Review, a comprehensive analysis of Canada's federal prison system. The release of this report, and the 'transformation' agenda that it presents, is being hailed as a pivotal moment in Canadian corrections, one that will significantly change the manner in which prisons and prisoners are governed. Using a form of Foucauldian discourse analysis, this study 'unpacks' the various meanings and effects that are produced by this report. Drawing on these findings, and through an application of the work of Michel Foucault and the governmentality approach, it then engages with the different ways in which mentalities and strategies of government, discipline and sovereignty are implicit in the 'transformation' agenda that is put forth. In doing so, it engages with Foucault's notion of the 'triangle' of governmentality. The conclusion of this study explores how the agenda presented constitutes a programme of governance with a dual mandate of repression and responsibilities, one that vacillates between strategies of coercion and subjugation and more 'gentle' and 'distant' technologies of self-government.
How academics in an engineering faculty at a newly formed university of technology perceive entrepreneurship
Creators: name: Esbach, Johan
Publisher: name: Swinburne
Year: 2024

description: This research examines the view that academics hold regarding the entrepreneurial perceptions of Cape Peninsula University of Technology (CPUT) students. In South Africa, the higher education challenges that students face seems enormous, the shortage of engineers continues to place a huge demand on Higher Educational Institutions (HEI) to deliver specialised skills also, the profound global technological change compounds the educational problems. This challenge is typical to a faculty structure, which by its definition suggests narrow focus and prescriptive activity. The entrepreneurial liberals in the engineering environment are arguing for an engineering school. Under the definition of 'school' there seems to be more room for effective diversification. Here the challenge is focused on the academic - industry relationship. A pushpull effect under threat from entrepreneurship simply because industry demands graduates with specialised technical skills while entrepreneurship produces graduates with both technical and non-technical skills. The dwindling engineering job market is evidence to the academic-industry relationship being out of sync with the national labour objective. SA industry is in a constant state of reengineering. This promotes engineering skills to immigrate hence increasing the demand for local specialised skills. This pressure is placed on the HEIs to deliver specialised technical skills. However, in the international skills market, the SA engineers are in demand because of their technical and non-technical ability. Entrepreneurship is not yet embraced in the SA economy often leading to decision-making processes which clearly the industry and academics in the engineering environment are not comfortable with. This research leads that in order to reverse the unemployment situation in South Africa; that HEIs interpret the balance between industry job creation and entrepreneurial wealth creation. Global Entrepreneurship Monitor (Gem) reports that South African graduates have the potential to reverse the negative growth in the job market, by way of wealth creation and job creation. The environment for effective decision-making may still be non-existent and academics would do well to put in place the structures to effect choice. Academics in the engineering environment subscribe to 'one right answer' and are generally narrow focused. Entrepreneurship challenges the science of 'one right answer' causing mayhem amongst academics that understand their environment to be clearly defined. Entrepreneurship seems to be met with great resistance, and rightly so. Entrepreneurship within the engineering fraternity is vague and like project management, it challenges the role of industry and in some ways, develops new ones. To adopt entrepreneurship into the strong CPUT culture is not easy but the empirical data will highlight the view that academics hold regarding the importance of nurturing an entrepreneurial culture.
The madwoman in the theatre: A re-evaluation of Canadian women playwrights and the English Canadian Dramatic Canon, 1966-1977
Creators: name: Talia, Lia Marie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: History, Canadian.
subject: Literature, Canadian (English).
subject: Women's Studies.
subject: Theater.

description: The period 1966-1977 saw the emergence of both the Canadian feminist movement and a new Canadian drama. This thesis explores how the work of four English Canadian female playwrights reflected both in their groundbreaking early work. Aviva Ravel, Beverley Simons, Carol Bolt, and Sharon Pollock were each concerned with women's roles and changing conventional perceptions of women. This may in part explain why critics view the early work of these four playwrights as proto-feminist rather than feminist. All four playwrights, although they often disavowed a feminist intent, wrote plays that reflected the ideological tenets of second-wave Anglo-American feminism. However, their plays also often depict a decidedly vexed feminist vision. They critiqued restrictions imposed on women, while simultaneously arguing for the importance of women's empowered contribution to society, but often their message is obscured by ambiguous characterizations, structures, and conclusions. In this way, these playwrights asserted a feminist vision and challenged authority and stereotypical depictions of women on stage, while attempting to evade the antipathy of audiences and critics. The feminist reflections of these four female playwrights during the initial stages of the second-wave feminist movement in Canada provide a fascinating glimpse into how these writers were able to create a role for themselves in Canadian theatre against the backdrop of the women's liberation movement. They may have concealed their feminist sympathies to varying degrees; however, they nonetheless put women's concerns centre-stage and began an examination of identity politics and gender socialization, especially in relation to the notion examination of identity politics of the performance of gender roles, that has continued for decades.
Development and characterization of magnetic SARS-CoV-2 peptide-imprinted polymers
Creators: name: Fresco-Cala, Beatriz
name: Rajpal, Soumya
name: Rudolf, Tamara
name: Keitel, Benedikt
name: Groß, Rüdiger
name: Münch, Jan
name: Batista, Alex D.
name: Mizaikoff, Boris
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: magnetic imprinted particles
subject: peptide imprinting
subject: epitope imprinting
subject: surrogate imprinting
subject: fragment imprinting
subject: virus imprinting
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Dopamine
subject: Molecularly Imprinted Polymers
subject: SARS-CoV-2
subject: Dopamin

description: The development of new methods for the rapid, sensitive, and selective detection of SARS-CoV-2 is a key factor in overcoming the global pandemic that we have been facing for over a year. In this work, we focused on the preparation of magnetic molecularly imprinted polymers (MMIPs) based on the self-polymerization of dopamine at the surface of magnetic nanoparticles (MNPs). Instead of using the whole SARS-CoV-2 virion as a template, a peptide of the viral spike protein, which is present at the viral surface, was innovatively used for the imprinting step. Thus, problems associated with the infectious nature of the virus along with its potential instability when used as a template and under the polymerization conditions were avoided. Dopamine was selected as a functional monomer following a rational computational screening approach that revealed not only a high binding energy of the dopamine–peptide complex but also multi-point interactions across the entire peptide template surface as opposed to other monomers with similar binding affinity. Moreover, variables affecting the imprinting efficiency including polymerization time and amount of peptide and dopamine were experimentally evaluated. Finally, the selectivity of the prepared MMIPs vs. other peptide sequences (i.e., from Zika virus) was evaluated, demonstrating that the developed MMIPs were only specific for the target SARS-CoV-2 peptide.
A Genre Based Approach to Teaching B1 Level E-Mail Writing for the World of Work
Creators: name: Hartle, Sharon
Publisher: name: Iperstoria
Year: 2019

description: In a professional world where communication technologies have become increasingly accessible and speed of delivery, as a result, is at a premium, it comes as little surprise that findings from a recent joint Quacquarelli Symonds (QS) / Cambridge Language Assessment study (2016) stress employers’ insistence on developing English language email writing skills as a priority, and this is particularly true of Italian companies. The implications of this need for specifically skill orientated, professional development in ESP writing are enormous but how far are they being reflected by the assessment criteria adopted by major examination boards and associations and, consequently, reflected in teaching practices? In Europe the ESP teaching field is increasingly informed by the Common European Framework of Reference (CEFR) but these descriptors may neglect the central role discourse elements play in contributing to an effective text. An interesting question to consider, then, is what type of washback is being created and whether or not a genre based approach, such as is common in approaches to EAP (Bhatia 1993; Swales 1990; Hyland 2008 ) might be effective when teaching email writing skills at B1 levels. This article, therefore, looks at some areas that are perhaps neglected and explores practical ways in which applying a genre based approach may foster awareness and improved production skills in B1 level email writing, focusing on how this has been carried out in undergraduate language courses with students studying Economics at Verona University.
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer’s disease
Creators: name: Zhang, Si
name: Zhao, Jiehao
name: Zhang, Yuhu
name: Zhang, Yun
name: Cai, Fang
name: Wang, Lijuan
name: Song, Weihong
Publisher: name: BioMed Central
Year: 2019

description: Background: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. Chronic inflammation induced by amyloid β proteins (Aβ) is one prominent neuropathological feature in Alzheimer’s disease (AD) brain. Methods: Elisa, Western blot, and immunohistochemical staining analysis were performed to examine the level of MIF protein in CSF and brain tissues. MTT and LDH assays were used to examine the neurotoxicity, and the Morris Water Maze test was performed to examine the cognitive function in the MIF+/−/APP23 transgenic mice. Results: MIF expression was upregulated in the brain of AD patients and AD model mice. Elevated MIF concentration was detected in the cerebrospinal fluid of AD patients but not in that of the patients suffering from mild cognitive impairment and vascular dementia. Reduced MIF expression impaired learning and memory in the AD model mice. MIF expression largely associates with Aβ deposits and microglia. The binding assay revealed a direct association between MIF and Aβ oligomers. Neurons instead of glial cells were responsible for the secretion of MIF upon stimulation by Aβ oligomers. In addition, overexpression of MIF significantly protected neuronal cells from Aβ-induced cytotoxicity. Conclusion: Our study suggests that neuronal secretion of MIF may serve as a defense mechanism to compensate for declined cognitive function in AD, and increased MIF level could be a potential AD biomarker.
Modelling and analysis of integrated machine-level planning problems for automated manufacturing.
Creators: name: Kolahan, Farhad.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Engineering, Industrial.

description: The wide application of NC technologies and the advance in integrated manufacturing have significantly improved productivity. This however also leads to complexity in shop floor planning, particularly in machine-level planing due to the increased flexibility in the selection of machining parameters, tools, and tool paths. Part sequencing, tool replacement and machining speed selection for metal cutting in general and tool set selection, machining speed specifications as well as path sequencing for hole making in particular have a direct impact on manufacturing economics and hence have drawn much attention of many researchers. However, these problems have been often solved in isolation to each other, thereby causing inconsistent and conflicting planning actions on the shop floor. As a result, the solutions obtained in such a way can not be used for real shop floor planning. At the best a lengthy process is needed to resolve the conflict between the separately obtained solutions. Such a decision process obviously does not meet the need of modern manufacturing environment where quick and consistent planning decisions are imperative. The main purpose of this study is to model and solve several combined planning problems facing today's manufacturing industry. These include (a) part sequencing and tool replacement with sequence-dependent setup times and probabilistic tool life; (b) Just-In-Time (JIT) part scheduling with variable processing times and sequence dependent setups; and (c) tool set selection, machining speed specification, operation sequencing and path selection for hole making operations. These problems are combinatorial in nature and are often classified as NP-complete. Consequently, optimal solutions may not be obtained within polynomial times. In this dissertation, tabu search technique has been employed to solve the above combined planning problems. The computational results have shown that these problems can be efficiently solved and consistent decisions can be made based on the solutions. The effects of some important parameters such as initial solutions, move selection, termination criteria, and tabu list size on the search performance have also been examined.
Vistas of English for Specific Purposes. Edited by Nadežda Stojković
Creators: name: Cacchiani, Silvia
Publisher: name: Iperstoria
Year: 2019
Subjects: English for Specific Purposes

description: Review of Vistas of English for Specific Purposes. Edited by Nadežda Stojković
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Conditioned Belief Propagation revisited (extended version)
Creators: name: Geier, Thomas
name: Richter, Felix
name: Biundo, Susanne
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Belief propagation
subject: Markov networks
subject: Probabilistic inference
subject: DDC 004 / Data processing & computer science
subject: Artificial intelligence
subject: Conditioning
subject: Markov-Zufallsfeld

description: Belief Propagation (BP) applied to cyclic problems is a well known approximate inference scheme for probabilistic graphical models. To improve its accuracy, Conditioned Belief Propagation (CBP) has been proposed, which splits a problem into subproblems by conditioning on variables, applies BP to subproblems, and merges the results to produce an answer to the original problem. In this work, we propose a reformulated version of CBP that exhibits anytime behavior and allows for more specific tuning by formalizing a further aspect of the algorithm through the use of a leaf selection heuristic. We propose several simple and easy to compute heuristics and demonstrate their performance using an empirical evaluation on randomly generated problems.
Advances in sequential measurement and control of open quantum systems
Creators: name: Gherardini, Stefano
name: Smirne, Andrea
name: Müller, Matthias M.
name: Caruso, Filippo
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Open quantum systems
subject: Quantum measurements and control
subject: Quantum Zeno physics
subject: Noise sensing
subject: DDC 530 / Physics
subject: Quantum theory
subject: Stochastische Analysis

description: Novel concepts, perspectives and challenges in measuring and controlling an open quantum system via sequential schemes are shown. We discuss how similar protocols, relying both on repeated quantum measurements and dynamical decoupling control pulses, can allow to: (i) Confine and protect quantum dynamics from decoherence in accordance with the Zeno physics. (ii) Analytically predict the probability that a quantum system is transferred into a target quantum state by means of stochastic sequential measurements. (iii) Optimally reconstruct the spectral density of environmental noise sources by orthogonalizing in the frequency domain the filter functions driving the designed quantum-sensor. The achievement of these tasks will enhance our capability to observe and manipulate open quantum systems, thus bringing advances to quantum science and technologies.
Eleonora Federici. Quando la fantascienza è donna. Dalle utopie femminili del secolo XIX all’età contemporanea
Creators: name: Adami, Valentina
Publisher: name: Iperstoria
Year: 2019
Subjects: Science fiction

description: Review of Quando la fantascienza è donna. Dalle utopie femminili del secolo XIX all’età contemporanea by Eleonora Federici
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 197 (25. Jg.), Mai 1995
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Uni Ulm intern
subject: Universities; Germany; Ulm
subject: Ulm / Universität

description: N/A
The adaptive response: I. Assessing the relative biological effectiveness of low doses of tritium. II. Determining its effect on DNA repair at a chromosomal level.
Creators: name: Broome, Ernest Jason.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Biology, Molecular.

description: The adaptive response, a phenomenon sensitive to low doses of ionizing radiation, was used to assess the relative biological effectiveness (RBE) of low doses of tritium. Normal human fibroblasts (AG1522) were grown in culture to confluence and exposed to tritium beta-particles or 60Co gamma-ray adapting doses ranging from 0.10 cGy to 50 cGy. These cells, and other unexposed cells, were allowed to adapt during a 3 h, 37°C incubation prior to a challenge dose of 4 Gy of 60Co gamma-rays. Cells were replated in the presence of cytochalasin B and adaption was assessed by measuring micronucleus frequency in binucleated cells. Fluorescence in situ hybridization using whole chromosome paints (WCP) was then employed to probe the chromosome content of radiation induced micronuclei in radiation-adapted and non-adapted fibroblasts. (Abstract shortened by UMI.)
Pratiques de santé et d'activité physique : entretiens avec des femmes cheffes de familles monoparentales.
Creators: name: Dumas, Alexandre.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Health Sciences, Recreation.

description: La presente etude vise a analyser et ameliorer la comprehension de certains aspects relatifs aux pratiques de sante et d'activite physique d'un groupe de femmes cheffes de familles monoparentales. L'etude a consiste a interviewer 7 femmes cheffes de familles monoparentales francophones du Quebec qui vivent dans des conditions socio-economiques precaires. Le protocole de recherche utilise une approche qualitative fondee sur des principes feministes et postmodernistes (Harding, 1991; Rail, 1998). La cueillette et l'analyse des donnees se sont deroulees selon des techniques empruntees a l'ethnographie et la socio-phenomenologie. NUD-IST. Enfin, la forme narrative a ete employee lors de la redaction afin de se coller le plus fidelement possible, a la parole des participantes. Les resultats ont ete divises en cinq chapitres: (a) la monoparentalite, (b) la perception de la sante, (c) les pratiques de sante, (d) les contraintes aux pratiques de sante et (e) les manifestations des contraintes aux pratiques de sante. De facon generale, les participantes reconnaissent l'importance d'une bonne sante mais s'adonnent a peu de pratiques de sante et d'activite physique. Plusieurs obstacles ont ete mentionnes a cet egard. Les limites reliees a l'education et l'emploi, le fardeau des responsabilites familiales, les conflits avec l'ex-conjoint, les politiques sociales deficientes et les elements repressifs de l'environnement social sont apparus comme des contraintes indirectes aux pratiques de sante et d'activite physique. De plus, d'autres types de contraintes affectent leur participation de facon plus directe: le manque de temps, le manque de ressource financiere, l'interiorisation forcee d'une ethique du soin et le surmenage. Les resultats de l'etude ont mene a quelques recommandations qui pourraient permettre d'accroitre la participation des femmes cheffes de familles monoparentales a diverses pratiques de sante et d'activite physique.
Motor management and energy saving by integration of motor drive system
Creators: name: Ektesabi, M.
name: Felic, H.
Publisher: name: Swinburne
Year: 2024

description: In this paper a new-generation integral motor-drive has been demonstrated. It proposes a compact unit built to operate in arduous industrial environments with optimized power consumption and best practice motor management under different load conditions. It is the first truly integrated motor-drive unit with a design to overcome heat, vibration and electromagnetic interference which are damaging to sensitive electronics without requirement of any additional cooling system. The critical issues such as; space limitations within the existing spatial dimensions of motor, management of heat transfer from the motor to the sensitive drive control unit, management of vibration transfer to the sensitive drive control unit, management of electromagnetic interference within the unit and externally, management of other environmental effects on the sensitive drive control unit have been considered and discussed in this paper.
Regulation of CD44 and its adhesive interactions with the extracellular matrix component, hyaluronan, by cytokines in normal and transformed human B lymphocytes.
Creators: name: Kryworuchko, Marko Andrii.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Health Sciences, Immunology.

description: The interaction of CD44 with its ligand hyaluronan may play a vital role in many biological processes including leukocyte homing, activation and effector function, hematopoiesis as well as tumor formation and metastasis. This phenomenon may be influenced by the extracellular matrix molecules and cytokines present in the microenvironment. In this study, I investigated the regulation of CD44-HA interactions in normal human B cells and in a panel of B cell lines including: Epstein-Barr virus (EBV)-positive (+) and EBV-negative (-) Burkitt's lymphoma (BL) and lymphoblastoid B cell lines (B-LCL) generated by in vitro EBV-transformation of normal human B cells. Activation of purified B cells with bacterial lipopolysaccharide (LPS), pokeweed mitogen (PWM) or anti-IgM antibodies in the presence or absence of interleukin (IL)-2 or IL-4 failed to induce HA adhesiveness. Stimulation of B cells with PMA however, induced strong HA recognition. Amongst a variety of cytokines that influence B cell activation, proliferation and differentiation, only IFN-gamma and to some extent IL-4 inhibited PMA-induced CD44-HA interactions. IL-13, which shares components of the IL-4 receptor complex and exhibits many biological effects similar to that of IL-4, failed to inhibit HA recognition. EBV infection/transformation of B cells, an alternative method of B cell activation, enhanced the expression of CD44 H, and induced a number CD44 V isofoms but abrogated their ability to bind HA in response to PMA. Stimulation with PMA induced strong HA recognition in the EBV-positive BL cell line BL-30/B95-8, whereas LPS, Staphylococcus aureus Cowan strain I (SAC) or PWM failed to induce HA adhesion. Investigation of the effect of a similar panel of cytokines revealed that in contrast to its inhibitory effect in normal human B cells, IL-4 was capable of inducing HA recognition in BL30/B95-8 cells. IL-13, again, failed to influence HA recognition. In contrast, the ability to recognize HA following PMA or IL-4 stimulation was not observed in B-LCL cells, highlighting the stark contrast between BL30/B95-8 and B-LCL cells. To understand the effect of EBV on CD44 expression and HA recognition, we investigated a panel of EBV- and EBV+ B cell lines. EBV- BL cells failed to express CD44 and hence did not adhere to HA. A remarkable heterogeneity was revealed by the study of various EBV+ B cell lines with respect to CD44 isoform expression and their ability to recognize HA. BL-30/B95-8, Jijoye, IM and all the B-LCLs tested expressed CD44 H and CD44 V isoforms; yet, Jijoye and B-LCLs failed to recognize HA in response to PMA. In conclusion, these results establish that HA recognition and CD44 isoform expression are modulated as a consequence of the mode of human B cell activation, differentiation and/or state of transformation. (Abstract shortened by UMI.)
A Preliminary Investigation on the Role of Brittle Fracture in the Kinematics of the 2014 San Leo Landslide
Creators: name: Donati, Davide
name: Stead, Doug
name: Elmo, Davide
name: Borgatti, Lisa
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The stability of high rock slopes is largely controlled by the location and orientation of geological features, such as faults, folds, joints, and bedding planes, which can induce structurally controlled slope instability. Under certain conditions, slope kinematics may vary with time, as propagation of existing fractures due to brittle failure may allow development of fully persistent release surfaces. In this paper, the progressive accumulation of brittle damage that occurred prior to and during the 2014 San Leo landslide (northern Italy) is investigated using a synthetic rock mass (SRM) approach. Mapping of brittle fractures, rock bridge failures, and major structures is undertaken using terrestrial laser scanning, photogrammetry, and high-resolution photography. Numerical analyses are conducted to investigate the role of intact rock fracturing on the evolution of kinematic freedom using the two-dimensional Finite-discrete element method (FDEM) code Elfen, and the three-dimensional lattice-spring scheme code Slope Model. Numerical analyses show that the gradual erosion of clay-rich material below the base of the plateau drives the brittle propagation of fractures within the rock mass, until a fully persistent, subvertical rupture surface form, causing toppling of fault-bounded rock columns. This study clearly highlights the potential role of intact rock fracturing on the slope kinematics, and the interaction between intact rock strength, structural geology, and slope morphology.
Exploring virtual world innovations and design through learner voices
Creators: name: Gregory, Sue
name: McDonald, Marcus
name: O’Connell, Judy
name: Jegathesan, Jay Jay
name: Stokes-Thompson, Frederick
name: Sim, Jenny
name: Hearns, Merle
name: Gregory, Brent
name: Nikolic, Sasha
name: Butler, Des
name: McGrath, Naomi
name: Sukunesan, Suku
name: Schutt, Stefan
name: Irving, Leah
name: Grant, Scott
name: Farley, Helen
name: Jacka, Lisa
name: Rudra, Amit
name: Zagami, Jason
name: Gaukrodger, Belma
Publisher: name: Swinburne
Year: 2024

description: Student voice has played a big role in shaping the development and measure of success/failure of virtual worlds in education. Data on past and ongoing educational uses and contexts of use of virtual worlds and associated student feedback was gathered via a survey of educational researchers specialising in virtual worlds. Introduced are a range of specific uses that provide the source of and context for student feedback. Ten major themes emerged from student voices that highlight strengths and weakness and point the way forward for both educators and the students themselves. Positive feedback highlighted experiences of both pedagogical design and the ability of the technology to support it. Negative feedback revolved around technical problems, seen as hampering the effectiveness of student learning experiences. Student voice regarding virtual worlds is both positive and rewarding, and commending of staff who have dedicated their time and effort to transform the learning experience.
The H2S donor sodium thiosulfate (Na2S2O3) does not improve inflammation and organ damage after hemorrhagic shock in cardiovascular healthy swine
Creators: name: Messerer, David Alexander Christian
name: Gässler, Holger
name: Hoffmann, Andrea
name: Gröger, Michael
name: Benz Morisoli, Kathrin
name: Huhn, Aileen
name: Hezel, Felix
name: Calzia, Enrico
name: Radermacher, Peter
name: Datzmann, Thomas
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Physical injuries
subject: Hemorrhage
subject: Systemic inflammation
subject: Hydrogen sulfide
subject: Animal model
subject: Gaseous mediator
subject: DDC 610 / Medicine & health
subject: Sodium thiosulphate
subject: Wounds and injuries
subject: Inflammation
subject: Hemorrhage
subject: Models, Animal
subject: Verletzung
subject: Entzündung
subject: Blutung
subject: Schwefelwasserstoff
subject: Tiermodell

description: We previously demonstrated marked lung-protective properties of the H2S donor sodium thiosulfate (Na2S2O3, STS) in a blinded, randomized, controlled, long-term, resuscitated porcine model of swine with coronary artery disease, i.e., with decreased expression of the H2S-producing enzyme cystathionine-γ-lyase (CSE). We confirmed these beneficial effects of STS by attenuation of lung, liver and kidney injury in mice with genetic CSE deletion (CSE-ko) undergoing trauma-and-hemorrhage and subsequent intensive care-based resuscitation. However, we had previously also shown that any possible efficacy of a therapeutic intervention in shock states depends both on the severity of shock as well as on the presence or absence of chronic underlying co-morbidity. Therefore, this prospective, randomized, controlled, blinded experimental study investigated the effects of the STS in cardiovascular healthy swine. After anesthesia and surgical instrumentation, 17 adult Bretoncelles-Meishan-Willebrand pigs were subjected to 3 hours of hemorrhage by removal of 30% of the blood volume and titration of the mean arterial pressure (MAP) ≈ 40 ± 5 mmHg. Afterwards, the animals received standardized resuscitation including re-transfusion of shed blood, fluids, and, if needed, continuous i.v. noradrenaline to maintain MAP at pre-shock values. Animals were randomly allocated to either receive Na2S2O3 or vehicle control starting 2 hours after initiation of shock until 24 hours of resuscitation. The administration of Na2S2O3 did not alter survival during the observation period of 68 hours after the initiation of shock. No differences in cardio-circulatory functions were noted despite a significantly higher cardiac output, which coincided with significantly more pronounced lactic acidosis at 24 hours of resuscitation in the Na2S2O3 group. Parameters of liver, lung, and kidney function and injury were similar in both groups. However, urine output was significantly higher in the Na2S2O3 group at 24 hours of treatment. Taken together, this study reports no beneficial effect of Na2S2O3 in a clinically relevant model of hemorrhagic shock-and-resuscitation in animals without underlying chronic cardiovascular co-morbidity.
Jeffrey Herlihy-Mera and Vamsi K. Koneru (eds.). Paris in American Literatures
Creators: name: Miazzo, Arianna
Publisher: name: Iperstoria
Year: 2019
Subjects: American Literature; Paris; Distance

description: Review of Paris in American Literatures by Jeffrey Herlihy-Mera and Vamsi K. Koneru (eds.)
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Mobility, fate and behavior of TiO2 nanomaterials in different environmental media
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013
Subjects: subject: Chemikalie
subject: Nanomaterialien
subject: Chemikalien
subject: Chemicals

description: Nanomaterials are nowadays used in increasing amounts in everyday products and special applications. Enhanced release of engineered nanomaterials (ENM) into the environment can hence be assumed. The first part of the study dealt with a method development for the stability testing of the coating of two different functionalised TiO2 nanomaterials. The stability was analysed covering different environmental conditions like pH, ionic strength and dissolved organic carbon concentration. The second part of this study analysed the carrier function of P25 for the two different substances, copper and 14C triclocarban, in three different soil types.
Quelle: www.umweltbundesamt.de

description: Nanomaterials are nowadays used in increasing amounts in everyday products and special applications. Enhanced release of engineered nanomaterials (ENM) into the environment can hence be assumed. The first part of the study dealt with a method development for the stability testing of the coating of two different functionalised TiO2 nanomaterials. The stability was analysed covering different environmental conditions like pH, ionic strength and dissolved organic carbon concentration. The second part of this study analysed the carrier function of P25 for the two different substances, copper and 14C triclocarban, in three different soil types.
Jahresbericht der Universität Ulm 2006
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 050 / General serial publications
subject: Research; Ulm
subject: Universities; Germany; Ulm
subject: Forschungsbericht
subject: Ulm / Universität

description: Jahresbericht der Universität Ulm 2006 in deutscher und englischer Sprache
Rubbish City and the Utopia of the Residual: In the Country of Last Things by Paul Auster
Creators: name: Cuozzo, Gianluca
Publisher: name: Iperstoria
Year: 2019

description: In his novel In the Country of Last Things, Paul Auster paints the picture of a rubbish city situated on the margins of the world of production. It is the wretched dwelling of outcasts, where garbage is the unsuspected and virtual repository of the fragments of collective desire. Yet, from the margins of this dystopian world rises a remnant of hope, which becomes an ontological principle – in other words, a new Utopia of marginality. In a kind of new ars combinatoria of the residual, the rubbles of the existent, i.e. the tiny intact islands of reality, can, in fact, be united with other similar ones “to create new archipelagoes of matter”. Thus, the “remnant of that which was” becomes a part of a constant strategy of delay, the last remnant of salvation, which procrastinates indefinitely the finis mundi.
description: Iperstoria, No 10 (2017): Specialized Discourses and ESP on the Web
Natural growth models: a decision making framework for entrepreneurial leadership in business growth
Creators: name: Benjamin, Eyal
name: Katzenstein, Liora
Publisher: name: Swinburne
Year: 2024

description: This research seeks to adopt Biomimetic principles in an entrepreneurial model that guides decision-making in high growth ventures. Biomimetics is a concept of taking ideas from nature and implementing them in other scientific fields: Material Engineering, Robotics, Sociology, Bio-Chemistry and others. Since sustainable growth is one of natures' best practices, it seems logical to apply this learning to entrepreneurship and the leadership of growth ventures. Biological entities (plants, trees etc,) are aimed to expand, enlarging their BioMass in the very same manner Businesses place focused efforts to accumulate BusinessMass. The model will present the corporation as a plant, using a Product/Service to connect between the Market and the Industry and utilizing Technology in order to convey Value to the market, hence capturing market share, and moving resources from the market back towards industry and research. Organizations compete on access to technological abilities as well as for market resources. Hence the biomimetic model can be outlined as follows (should be presented in a table): Plants: Habitat - The external forces enabling or preventing plant activity. Roots - Absorbing water from the ground, enabling Plant growth. Trunk - An internal system connecting the Roots to the Foliage and vice a versa, enabling water flow to leafs, as well as sugar flow back to the roots. Foliage - Absorb sunlight from the environment in order to create sugar by using water and the release of oxygen (photosynthesis). Business: Environment - The external forces supporting or preventing business activity. Technology - Absorbing potential value from science and industry, enabling Business growth. Product - An internal system connecting technology to the market and vice a versa, enabling flow of value to the market and flow of cash to R&D. Marketing - Absorb cash resources from the environment by converting value into cash. By identifying the four growth-related variables (Technology, Product, Market and Environment) an entrepreneurial organization can select out of 16 growth path alternatives. To a certain extent this model is an expansion of the Ansoff model that maps Market and Product as the 2 growth variables, yet this model aims to better fit today's business needs such as Internet based marketing, overlapping technologies etc. By analysing the Transfer Prices and Time parameters for each alternative, entrepreneurial leaders can better define a Growth Pattern suitable for their business, or alternatively adjust their business structure to fit a required growth path. The proposed research will add a unique view on entrepreneurial business growth, developing a measurable price/risk and return for every growth alternative that, when known and compared, can provide company leaders with a profound base for decision making.