cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Network inefficiencies in autism spectrum disorder at 24 months
Creators: name: Kostopoulos, P
name: Evans, A C
name: Hazlett, H
name: Dager, S
name: Lewis, J D
name: Pruett, J R
name: Botteron, K
name: Estes, A
name: Zwaigenbaum, L
name: McKinstry, R
name: Collins, L
name: Schultz, R T
name: Paterson, S
name: Styner, M
name: Piven, J
name: Gerig, G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral symptoms that emerge during the first years of life. Associated with these symptoms are differences in the structure of a wide array of brain regions, and in the connectivity between these regions. However, the use of cohorts with large age variability and participants past the generally recognized age of onset of the defining behaviors means that many of the reported abnormalities may be a result of cascade effects of developmentally earlier deviations. This study assessed differences in connectivity in ASD at the age at which the defining behaviors first become clear. There were 113 24-month-old participants at high risk for ASD, 31 of whom were classified as ASD, and 23 typically developing 24-month-old participants at low risk for ASD. Utilizing diffusion data to obtain measures of the length and strength of connections between anatomical regions, we performed an analysis of network efficiency. Our results showed significantly decreased local and global efficiency over temporal, parietal and occipital lobes in high-risk infants classified as ASD, relative to both low- and high-risk infants not classified as ASD. The frontal lobes showed only a reduction in global efficiency in Broca's area. In addition, these same regions showed an inverse relation between efficiency and symptom severity across the high-risk infants. The results suggest delay or deficits in infants with ASD in the optimization of both local and global aspects of network structure in regions involved in processing auditory and visual stimuli, language and nonlinguistic social stimuli.
Non-Gaussianity excess problem in classical bouncing cosmologies
Creators: name: Gao, Xian
name: Lilley, Marc
name: Peter, Patrick
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The simplest possible classical model leading to a cosmological bounce is examined in the light of the non-Gaussianities it can generate. Concentrating solely on the transition between contraction and expansion, and assuming initially purely Gaussian perturbations at the end of the contracting phase, we find that the bounce acts as a source such that the resulting value for the post-bounce $f_{\mathrm{NL}}$ may largely exceed all current limits, to the point of potentially casting doubts on the validity of the perturbative expansion. We conjecture that if one can assume that the non-Gaussianity production depends only on the bouncing behavior of the scale factor and not on the specifics of the model examined, then many realistic models in which a nonsingular classical bounce takes place could exhibit a generic non-Gaussianity excess problem that would need to be addressed for each case.
description: 7 pages, 2 figures. Inclusion of additional results (equations and plots) and more detailed discussion in the introduction and main body. Accepted for publication in Physical Review D
Topological Pressure for the Completely Irregular Set of Birkhoff Averages
Creators: name: Tian, Xueting
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37B10, 37B20, 37B40, 37D20, 37D25, 54H20

description: In this paper we mainly study the dynamical complexity of Birkhoff ergodic average under the simultaneous observation of any number of continuous functions. These results can be as generalizations of [6,35] etc. to study Birkhorff ergodic average from one (or finite) observable function to any number of observable functions from the dimensional perspective. For any topological dynamical system with $g-$almost product property and uniform separation property, we show that any {\it jointly-irregular set}(i.e., the intersection of a series of $ϕ-$irregular sets over several continuous functions) either is empty or carries full topological pressure. In particular, if further the system is not uniquely ergodic, then the {\it completely-irregular set}(i.e., intersection of all possible {\it nonempty $ϕ-$irregular} sets) is nonempty(even forms a dense $G_δ$ set) and carries full topological pressure. Moreover, {\it irregular-mix-regular sets} (i.e., intersection of some $ ϕ-$irregular sets and $ φ-$regular sets) are discussed. Similarly, the above results are suitable for the case of BS-dimension. As consequences, these results are suitable for any system such as shifts of finite type or uniformly hyperbolic diffeomorphisms, time-1 map of uniformly hyperbolic flows, repellers, $β-$shifts etc..
description: The title "Joint Birkhoff Ergodic Average and Topological Pressure" is changed by "Topological Pressure for the Completely Irregular Set of Birkhoff Averages"
Transcriptional targets of the schizophrenia risk gene MIR137
Creators: name: Sethupathy, P
name: Sullivan, P F
name: Kim, Y
name: Kelada, S N
name: Bloom, R J
name: Collins, A L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Genome-wide association studies (GWAS) have strongly implicated MIR137 (the gene encoding the microRNA miR-137) in schizophrenia. A parsimonious hypothesis is that a pathway regulated by miR-137 is important in the etiology of schizophrenia. Full evaluation of this hypothesis requires more definitive knowledge about biological targets of miR-137, which is currently lacking. Our goals were to expand knowledge of the biology of miR-137 by identifying its empirical targets, and to test whether the resulting lists of direct and indirect targets were enriched for genes and pathways involved in risk for schizophrenia. We overexpressed miR-137 in a human neural stem cell line and analyzed gene expression changes at 24 and 48 h using RNA sequencing. Following miR-137 overexpression, 202 and 428 genes were differentially expressed after 24 and 48 h. Genes differentially expressed at 24 h were enriched for transcription factors and cell cycle genes, and differential expression at 48 h affected a wider variety of pathways. Pathways implicated in schizophrenia were upregulated in the 48 h findings (major histocompatibility complex, synapses, FMRP interacting RNAs and calcium channels). Critically, differentially expressed genes at 48 h were enriched for smaller association P-values in the largest published schizophrenia GWAS. This work provides empirical support for a role of miR-137 in the etiology of schizophrenia.
Additional file 1 of Qualitative longitudinal research in health research: a method study
Creators: name: Audulv, Åsa
name: Hall, Elisabeth O. C.
name: Kneck, Åsa
name: Westergren, Thomas
name: Fegran, Liv
name: Pedersen, Mona Kyndi
name: Aagaard, Hanne
name: Dam, Kristianna Lund
name: Ludvigsen, Mette Spliid
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. PRISMA-ScR checklist.
Critical capacitance and charge-vortex duality near the superfluid to insulator transition
Creators: name: Gazit, Snir
name: Podolsky, Daniel
name: Auerbach, Assa
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Using a generalized reciprocity relation between charge and vortex conductivities at complex frequencies in two space dimensions, we identify the capacitance in the insulating phase as a measure of vortex condensate stiffness. We compute the ratio of boson superfluid stiffness to vortex condensate stiffness at mirror points to be 0.21(1) for the relativistic O(2) model. The product of dynamical conductivities at mirror points is used as a test of charge-vortex duality. We propose the finite wave vector compressibility as an experimental measure of the vortex condensate stiffness for neutral lattice bosons.
description: 10 pages, 10 figures, published version, improved discussion on the charge vortex duality in the introduction, added a supplementary material section on finite size scaling analysis of the critical energy scales, added to the supplementary material a comparison with other methods for analyzing the high frequency correction to scaling
Variational Principles for Stochastic Fluid Dynamics
Creators: name: Holm, Darryl D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: This paper derives stochastic partial differential equations (SPDEs) for fluid dynamics from a stochastic variational principle (SVP). The Legendre transform of the Lagrangian formulation of these SPDEs yields their Lie-Poisson Hamiltonian form. The paper proceeds by: taking variations in the SVP to derive stochastic Stratonovich fluid equations; writing their Itô representation; and then investigating the properties of these stochastic fluid models in comparison with each other, and with the corresponding deterministic fluid models. The circulation properties of the stochastic Stratonovich fluid equations are found to closely mimic those of the deterministic ideal fluid models. As with deterministic ideal flows, motion along the stochastic Stratonovich paths also preserves the helicity of the vortex field lines in incompressible stochastic flows. However, these Stratonovich properties are not apparent in the equivalent Itô representation, because they are disguised by the quadratic covariation drift term arising in the Stratonovich to Itô transformation. This term is a geometric generalisation of the quadratic covariation drift term already found for scalar densities in Stratonovich's famous 1966 paper. The paper also derives motion equations for two examples of stochastic geophysical fluid dynamics (SGFD); namely, the Euler-Boussinesq and quasigeostropic approximations.
description: 19 pages, no figures, 2nd version. To appear in Proc Roy Soc A. Comments to author are still welcome!
Additional file 2 of Qualitative longitudinal research in health research: a method study
Creators: name: Audulv, Åsa
name: Hall, Elisabeth O. C.
name: Kneck, Åsa
name: Westergren, Thomas
name: Fegran, Liv
name: Pedersen, Mona Kyndi
name: Aagaard, Hanne
name: Dam, Kristianna Lund
name: Ludvigsen, Mette Spliid
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Data base searches.
Justifying the Naive Partonic Sum Rule for Proton Spin
Creators: name: Ji, Xiangdong
name: Zhang, Jian-Hui
name: Zhao, Yong
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We provide a theoretical basis for understanding the spin structure of the proton in terms of the spin and orbital angular momenta of free quarks and gluons in Feynman's parton picture. We show that each term in the Jaffe-Manohar spin sum rule can be related to the matrix element of a gauge-invariant, but frame-dependent operator through a matching formula in large-momentum effective field theory. We present all the matching conditions for the spin content at one-loop order in perturbation theory, which provide a basis to calculate parton orbital angular momentum in lattice QCD at leading logarithmic accuracy.
description: 10 pages
Additional file 3 of Qualitative longitudinal research in health research: a method study
Creators: name: Audulv, Åsa
name: Hall, Elisabeth O. C.
name: Kneck, Åsa
name: Westergren, Thomas
name: Fegran, Liv
name: Pedersen, Mona Kyndi
name: Aagaard, Hanne
name: Dam, Kristianna Lund
name: Ludvigsen, Mette Spliid
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Guidelines for data charting
Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia
Creators: name: Friedl, M
name: Ripke, S
name: Ingason, A
name: Giegling, I
name: Hartmann, A M
name: Mirnics, K
name: Konte, B
name: Rujescu, D
name: Sullivan, P F
name: St. Clair, D
name: Collier, D A
name: O'Donovan, M C
name: Genius, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Antagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy individuals and exacerbate schizophrenia symptoms in patients. In this study we have produced an animal model of NMDA receptor hypofunction by chronically treating rats with low doses of the NMDA receptor antagonist MK-801. Subsequently, we performed an expression study and identified 20 genes showing altered expression in the brain of these rats compared with untreated animals. We then explored whether the human orthologs of these genes are associated with schizophrenia in the largest schizophrenia genome-wide association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4. Interestingly, three of these genes, FOXP1, SF3B1 and DLG2, have previously been implicated in neurodevelopmental disorders.
Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways
Creators: name: Wildman, D E
name: Ratanatharathorn, A
name: Aiello, A E
name: Almli, L M
name: Ressler, K
name: Meyers, J L
name: Koenen, K C
name: Uddin, M
name: Galea, S
name: Salling, M C
name: Bradley, B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Rodent models implicate metabotropic glutamate receptors (mGluRs) and downstream signaling pathways in addictive behaviors through metaplasticity. One way mGluRs can influence synaptic plasticity is by regulating the local translation of AMPA receptor trafficking proteins via eukaryotic elongation factor 2 (eEF2). However, genetic variation in this pathway has not been examined with human alcohol use phenotypes. Among a sample of adults living in Detroit, Michigan (Detroit Neighborhood Health Study; n=788; 83% African American), 206 genetic variants across the mGluR–eEF2–AMPAR pathway (including GRM1, GRM5, HOMER1, HOMER2, EEF2K, MTOR, EIF4E, EEF2, CAMK2A, ARC, GRIA1 and GRIA4) were found to predict number of drinking days per month (corrected P-value <0.01) when considered as a set (set-based linear regression conducted in PLINK). In addition, a CpG site located in the 3′-untranslated region on the north shore of EEF2 (cg12255298) was hypermethylated in those who drank more frequently (P<0.05). Importantly, the association between several genetic variants within the mGluR–eEF2–AMPAR pathway and alcohol use behavior (i.e., consumption and alcohol-related problems) replicated in the Grady Trauma Project (GTP), an independent sample of adults living in Atlanta, Georgia (n=1034; 95% African American), including individual variants in GRM1, GRM5, EEF2, MTOR, GRIA1, GRIA4 and HOMER2 (P<0.05). Gene-based analyses conducted in the GTP indicated that GRM1 (empirical P<0.05) and EEF2 (empirical P<0.01) withstood multiple test corrections and predicted increased alcohol consumption and related problems. In conclusion, insights from rodent studies enabled the identification of novel human alcohol candidate genes within the mGluR–eEF2–AMPAR pathway.
Additional file 4 of Qualitative longitudinal research in health research: a method study
Creators: name: Audulv, Åsa
name: Hall, Elisabeth O. C.
name: Kneck, Åsa
name: Westergren, Thomas
name: Fegran, Liv
name: Pedersen, Mona Kyndi
name: Aagaard, Hanne
name: Dam, Kristianna Lund
name: Ludvigsen, Mette Spliid
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 4. List of excluded articles
Genome-wide copy-number variation study of psychosis in Alzheimer’s disease
Creators: name: Demirci, F Y
name: Sweet, R A
name: Lopez, O L
name: Kamboh, M I
name: Barmada, M M
name: Richardson, G A
name: Feingold, E
name: Zheng, X
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: About 40–60% of patients with late-onset Alzheimer's disease (AD) develop psychosis, which represents a distinct phenotype of more severe cognitive and functional deficits. The estimated heritability of AD+P is ~61%, which makes it a good target for genetic mapping. We performed a genome-wide copy-number variation (CNV) study on 496 AD cases with psychosis (AD+P), 639 AD subjects with intermediate psychosis (AD intermediate P) and 156 AD subjects without psychosis (AD−P) who were recruited at the University of Pittsburgh Alzheimer's Disease Research Center using over 1 million single-nucleotide polymorphisms (SNPs) and CNV markers. CNV load analysis found no significant difference in total and average CNV length and CNV number in the AD+P or AD intermediate P groups compared with the AD−P group. Our analysis revealed a marginally significant lower number of duplication events in AD+P cases compared with AD−P controls (P=0.059) using multivariable regression model. The most interesting finding was the presence of a genome-wide significant duplication in the APC2 gene on chromosome 19, which was protective against developing AD+P (odds ratio=0.42; P=7.2E−10). We also observed suggestive associations of duplications with AD+P in the SET (P=1.95E−06), JAG2 (P=5.01E−07) and ZFPM1 (P=2.13E−07) genes and marginal association of a deletion in CNTLN (P=8.87E−04). We have identified potential novel loci for psychosis in Alzheimer's disease that warrant follow-up in large-scale independent studies.
Real-space calculation of the conductivity tensor for disordered topological matter
Creators: name: Garcia, Jose H.
name: Covaci, Lucian
name: Rappoport, Tatiana G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We describe an efficient numerical approach to calculate the longitudinal and transverse Kubo conductivities of large systems using Bastin's formulation. We expand the Green's functions in terms of Chebyshev polynomials and compute the conductivity tensor for any temperature and chemical potential in a single step. To illustrate the power and generality of the approach, we calculate the conductivity tensor for the quantum Hall effect in disordered graphene and analyze the effect of the disorder in a Chern insulator in Haldane's model on a honeycomb lattice.
description: 5 pages, 3 figures and a supplementary material (3 pages)
Use of the second-generation antipsychotic, risperidone and secondary weight gain are associated with an altered gut microbiota in children
Creators: name: Tyler, B C
name: Oltman, C L
name: Bahr, S M
name: Kirby, J R
name: Burns, T L
name: Teesch, L M
name: Azcarate-Peril, M A
name: Calarge, C A
name: Wooldridge, N
name: Butcher, B D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The atypical antipsychotic risperidone (RSP) is often associated with weight gain and cardiometabolic side effects. The mechanisms for these adverse events are poorly understood and, undoubtedly, multifactorial in etiology. In light of growing evidence implicating the gut microbiome in the host's energy regulation and in xenobiotic metabolism, we hypothesized that RSP treatment would be associated with changes in the gut microbiome in children and adolescents. Thus, the impact of chronic (>12 months) and short-term use of RSP on the gut microbiome of pediatric psychiatrically ill male participants was examined in a cross-sectional and prospective (up to 10 months) design, respectively. Chronic treatment with RSP was associated with an increase in body mass index (BMI) and a significantly lower ratio of Bacteroidetes:Firmicutes as compared with antipsychotic-naïve psychiatric controls (ratio=0.15 vs 1.24, respectively; P<0.05). Furthermore, a longitudinal observation, beginning shortly after onset of RSP treatment, revealed a gradual decrease in the Bacteroidetes:Firmicutes ratio over the ensuing months of treatment, in association with BMI gain. Lastly, metagenomic analyses were performed based on extrapolation from 16S ribosomal RNA data using the software package, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Those data indicate that gut microbiota dominating the RSP-treated participants are enriched for pathways that have been implicated in weight gain, such as short-chain fatty acid production.
The Visible and Infrared Survey Telescope for Astronomy (VISTA): Design, Technical Overview and Performance
Creators: name: Sutherland, Will
name: Emerson, Jim
name: Dalton, Gavin
name: Atad-Ettedgui, Eli
name: Beard, Steven
name: Bennett, Richard
name: Bezawada, Naidu
name: Born, Andrew
name: Caldwell, Martin
name: Clark, Paul
name: Craig, Simon
name: Henry, David
name: Jeffers, Paul
name: Little, Bryan
name: McPherson, Alistair
name: Murray, John
name: Stewart, Malcolm
name: Stobie, Brian
name: Terrett, David
name: Ward, Kim
name: Whalley, Martin
name: Woodhouse, Guy
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Visible and Infrared Survey Telescope for Astronomy (VISTA) is the 4-metre wide-field survey telescope at ESO's Paranal Observatory, equipped with the world's largest near-infrared imaging camera (VISTA IR Camera, VIRCAM), with 1.65 degree diameter field of view, and 67 Mpixels giving 0.6 square degrees active pixel area, operating at wavelengths 0.8 - 2.3 microns. We provide a short history of the project, and an overview of the technical details of the full system including the optical design, mirrors, telescope structure, IR camera, active optics, enclosure and software. The system includes several innovative design features such as the f/1 primary mirror, the dichroic cold-baffle camera design and the sophisticated wavefront sensing system delivering closed-loop 5-axis alignment of the secondary mirror. We conclude with a summary of the delivered performance, and a short overview of the six ESO public surveys in progress on VISTA.
description: Latex, 28 pages, 14 figures. v2 matches A&A published version, minor additions/corrections from v1
Blood outgrowth endothelial cell migration and trapping in vivo: a window into gene therapy
Creators: name: Bodempudi, Vidya
name: Nichols, Timothy C.
name: Hebbel, Robert P.
name: Enenstein, Judy A.
name: Milbauer, Liming C.
name: Solovey, Anna
name: Roney, Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Human blood outgrowth endothelial cells (hBOEC) may be useful delivery-cells for gene therapy. hBOEC have high expansion capacity and stable phenotype. If incorporated into blood vessels, hBOEC could release therapeutic agents directly into the blood stream. However, little is known about lodging and homing of hBOEC in vivo. We examined the homing patterns of hBOEC in mice, and explored extending cell-based FVIII gene therapy from mice to larger animals. hBOEC were injected into NOD/SCID mice to determine where they localize, how localization changes over time and if there were toxic effects on host organs. The presence of hBOEC in mouse organs was determined by qPCR and immunofluorescence microscopy. hBOEC lodged most notably in mouse lungs at 3 h, but by 24 h there were no differences between 9 organs. hBOEC longevity was assessed up to 7 months in vivo. hBOEC expanded well and then plateaued in vivo. hBOEC from older cultures expanded equally well in vivo as younger. hBOEC caused no noticeable organ toxicity up to 3 days post-injection. When mice were pretreated with antibodies to E-selectin, P-selectin or anti-α4 integrin prior to hBOEC injection, the number of hBOEC in lungs at 3h was inhibited. Preliminary studies infusing hemophilic dogs with autologous canine BOEC over-expressing FVIII (B-domain deleted) showed improvement in whole blood clotting times (WBCT). In conclusion, the survivability, expandability and lack of toxicity of BOEC in vivo indicate that they may be valuable host cells for gene therapy.
MicroRNA expression profiles differentiate chronic pain condition subtypes
Creators: name: Ciszek, Brittney P.
name: Bair, Eric
name: Nackley, Andrea G.
name: Zolnoun, Denniz
name: Maixner, William
name: Smith, Shad
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Chronic pain is a significant healthcare problem, ineffectively treated due to its unclear etiology and heterogeneous clinical presentation. Emerging evidence demonstrates that microRNAs regulate the expression of pain-relevant genes, yet little is known about their role in chronic pain. Here, we evaluate the relationship between pain, psychological characteristics, plasma cytokines and whole blood microRNAs in 22 healthy controls (HC); 33 subjects with chronic pelvic pain (vestibulodynia: VBD); and 23 subjects with VBD and irritable bowel syndrome (VBD+IBS). VBD subjects were similar to HCs in self-reported pain, psychological profiles and remote bodily pain. VBD+IBS subjects reported decreased health and function; and an increase in headaches, somatization and remote bodily pain. Furthermore, VBD subjects exhibited a balance in pro- and anti-inflammatory cytokines, while VBD+IBS subjects failed to exhibit a compensatory increase in anti-inflammatory cytokines. VBD subjects differed from controls in expression of 10 microRNAs of predicted importance for pain and estrogen signaling. VBD+IBS subjects differed from controls in expression of 11 microRNAs of predicted importance for pain, cell physiology and insulin signaling. MicroRNA expression was correlated with pain-relevant phenotypes and cytokine levels. These results suggest microRNAs represent a valuable tool for differentiating VBD subtypes (localized pain with apparent peripheral neurosensory disruption versus widespread pain with a central sensory contribution) that may require different treatment approaches.
Additional file 5 of Qualitative longitudinal research in health research: a method study
Creators: name: Audulv, Åsa
name: Hall, Elisabeth O. C.
name: Kneck, Åsa
name: Westergren, Thomas
name: Fegran, Liv
name: Pedersen, Mona Kyndi
name: Aagaard, Hanne
name: Dam, Kristianna Lund
name: Ludvigsen, Mette Spliid
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 5. Table of included articles (author(s), year of publication, reference, country, aims and research questions, methodology, type of data material, length of data collection period, number of participants)
Household Size and Consumption Behavior in the Korean Food Demand System
Creators: name: Kwon, Ohsang
name: Kwon, Ohsang
Publisher: name: Unknown
Year: 2022
Subjects: subject: Consumer/Household Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Demand System
subject: Household Size
subject: EASI demand system

description: We estimated an EASI (Exact Affine Stone Index) food demand system in Korea using the quarterly data of the period 2006-2021 to investigate the impacts of the family structure on food expenditures. Family structure variables of the model include family size, household head age, and income sources (wage vs. non-wage). The marginal impacts of these household characteristics as well as those of family income and food preference changes over time were estimated. We identified food preference differences among families with a single member, two members, three members, four members, and five and more members. It is shown that both single-member families and two-member families prefer more fishery products and fruits but less grain, meat, and dairy products than large-sized families. However, those two types of small-sized families revealed preferences on processed foods different from each other. Based on the estimation results, we simulated the changes in food expenditures caused by the simultaneous changes in family size, age, and the proportion of wage earners for the last 15 years. It is shown that the family structure change affected fresh food expenditures more than processed food expenditures. We found that the observed trend of increasing shares of meat and processed foods would have been even strengthened if there had been no changes in the family structure.
Defining the Ischemic Penumbra Using Hyperacute Neuroimaging: Deriving Quantitative Ischemic Thresholds
Creators: name: An, Hongyu
name: Lee, Jin-Moo
name: Lin, Weili
name: Vo, Katie D.
name: Ford, Andria L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Despite three decades of promise, a neuro-imaging biomarker capable of delineating the ischemic penumbra is yet to be definitively demonstrated. Much progress has been made, especially with MR imaging. However, in order to rigorously define an imaging biomarker of the ischemic penumbra, carefully designed studies which can derive ischemic thresholds using quantitative imaging parameters may be required. Two thresholds are of interest: one which distinguishes the ischemic core from penumbra, and another which distinguishes the penumbra from benign oligemia. In this review, we discuss one possible approach to define these thresholds by following tissue fate in the presence or absence of early reperfusion.
Approximations of Lipschitz maps via immersions and differentiable exotic sphere theorems
Creators: name: Kondo, Kei
name: Tanaka, Minoru
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 49J52, 53C20, Secondary 57R12, 57R55

description: As our main theorem, we prove that a Lipschitz map from a compact Riemannian manifold $M$ into a Riemannian manifold $N$ admits a smooth approximation via immersions if the map has no singular points on $M$ in the sense of F.H. Clarke, where $\dim M \leq \dim N$. As its corollary, we have that if a bi-Lipschitz homeomorphism between compact manifolds and its inverse map have no singular points in the same sense, then they are diffeomorphic. We have three applications of the main theorem: The first two of them are two differentiable sphere theorems for a pair of topological spheres including that of exotic ones. The third one is that a compact $n$-manifold $M$ is a twisted sphere and there exists a bi-Lipschitz homeomorphism between $M$ and the unit $n$-sphere $S^n(1)$ which is a diffeomorphism except for a single point, if $M$ satisfies certain two conditions with respect to critical points of its distance function in the Clarke sense. Moreover, we have three corollaries from the third theorem; the first one is that for any twisted sphere $Σ^n$ of general dimension $n$, there exists a bi-Lipschitz homeomorphism between $Σ^n$ and $S^n(1)$ which is a diffeomorphism except for a single point. In particular, there exists such a map between an exotic $n$-sphere $Σ^n$ of dimension $n>4$ and $S^n(1)$; the second one is that if an exotic $4$-sphere $Σ^4$ exists, then $Σ^4$ does not satisfy one of the two conditions above; the third one is that for any Grove-Shiohama type $n$-sphere $N$, there exists a bi-Lipschitz homeomorphism between $N$ and $S^n(1)$ which is a diffeomorphism except for one of points that attain their diameters.
description: 39 pages, no figures, minor corrections
Clinically Relevant Reperfusion in Acute Ischemic Stroke: MTT Performs Better than Tmax and TTP
Creators: name: Ford, Andria L.
name: Powers, William J.
name: Kong, Linglong
name: Lee, Jin-Moo
name: Zhu, Hongtu
name: Lin, Weili
name: Vo, Katie D.
name: An, Hongyu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: While several MRI parameters are used to assess tissue perfusion during hyperacute stroke, it is unclear which is optimal for measuring clinically-relevant reperfusion. We directly compared MTT prolongation (MTTp), TTP, and time-to-maximum (Tmax) to determine which best predicted neurological improvement and tissue salvage following early reperfusion.
Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance
Creators: name: Frelinger, Jeffrey A.
name: Hess, Paul R.
name: Vincent, Benjamin G.
name: Buntzman, Adam S.
name: Collins, Edward J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which arise from diverse genetic disparities between donor and recipient outside the MHC, are an important cause of rejection of MHC-matched grafts. Because clinically significant responses appear to be directed at only a few antigens, the selective deletion of naïve T cells recognizing donor-specific, immunodominant minor H antigens in recipients before transplantation may be a useful tolerogenic strategy. We have previously demonstrated that peptide-MHC class I tetramers coupled to a toxin can efficiently eliminate specific TCR-transgenic T cells in vivo. Here, using the minor histocompatibility antigen HY as a model, we investigated whether toxic tetramers could inhibit the subsequent priming of the two H2-Db-restricted, immunodominant T-cell responses by deleting precursor CTL. Immunization of female mice with male bone marrow elicited robust CTL activity against the Uty and Smcy epitopes, with Uty constituting the major response. As hypothesized, toxic tetramer administration prior to immunization increased survival of cognate peptide-pulsed cells in an in vivo CTL assay, and reduced the frequency of corresponding T cells. However, tetramer-mediated decreases in either T-cell population magnified CTL responses against the non-targeted epitope, suggesting that Db-Uty+ and Db-Smcy+ T cells compete for a limited common resource during priming. Toxic tetramers conceivably could be used in combination to dissect or manipulate CD8+ T-cell immunodominance hierarchies, and to prevent the induction of donor-specific, minor H antigen CTL responses in allotransplantation.
Explosive Formation and Dynamics of Vapor Nanobubbles around a Continuously Heated Gold Nanosphere
Creators: name: Hou, Lei
name: Yorulmaz, Mustafa
name: Verhart, Nico R.
name: Orrit, Michel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We form sub-micrometer-sized vapor bubbles around a single laser heating gold nanoparticle in a liquid and monitor them through optical scattering of a probe laser. The fast, inertia-governed expansion is followed by a slower contraction and disappearance after some tens of nanoseconds. In a narrow range of illumination powers, bubble time traces show a clear echo signature. We attribute it to sound waves released upon the initial explosion and reflected by flat interfaces, hundreds of microns away from the particle. Echoes can trigger new explosions. A steady state of nanobubble with a vapor shell surrounding the heated nanoparticle can be reached by a proper time profile of the heating intensity. Stable nanobubbles could have original applications for light modulation and for enhanced optical-acoustic coupling in photoacoustic microscopy.
title: I nemici della musica
Creators: name: Principe , Quirino
Publisher: name: Roma Tre-Press
Year: 2010

description: Questo scritto è una sorta di «chiamata alle armi» per affrontare tutti coloro hanno offeso, umiliato e osteggiato l'immensa tradizione culturale italiana fino a ridurre la musica "forte" all'infausto stato attuale in cui versa. Si invoca un nuovo punto di partenza, un nuovo inizio, dal quale far sì che la musica riacquisti vita, sviluppo e forza, ossia che coloro che studiano musica imparino a farla, non soltanto a parlarne.

description: B@belonline vol. 8 Musica e Bildung. Saper suonare e imparare ad ascoltare
A new model to predict weak-lensing peak counts I. Comparison with $N$-body Simulations
Creators: name: Lin, Chieh-An
name: Kilbinger, Martin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Weak-lensing peak counts has been shown to be a powerful tool for cosmology. It provides non-Gaussian information of large scale structures, complementary to second order statistics. We propose a new flexible method to predict weak lensing peak counts, which can be adapted to realistic scenarios, such as a real source distribution, intrinsic galaxy alignment, mask effects, photo-$z$ errors from surveys, etc. The new model is also suitable for applying the tomography technique and non-linear filters. A probabilistic approach to model peak counts is presented. First, we sample halos from a mass function. Second, we assign them NFW profiles. Third, we place those halos randomly on the field of view. The creation of these "fast simulations" requires much less computing time compared to $N$-body runs. Then, we perform ray-tracing through these fast simulation boxes and select peaks from weak-lensing maps to predict peak number counts. The computation is achieved by our \textsc{Camelus} algorithm, which we make available at http://www.cosmostat.org/software/camelus/ . We compare our results to $N$-body simulations to validate our model. We find that our approach is in good agreement with full $N$-body runs. We show that the lensing signal dominates shape noise and Poisson noise for peaks with SNR between 4 and 6. Also, counts from the same SNR range are sensitive to $Ω_\mathrm{m}$ and $σ_8$. We show how our model can discriminate between various combinations of those two parameters. In summary, we offer a powerful tool to study weak lensing peaks. The potential of our forward model is its high flexibility, making the use of peak counts under realistic survey conditions feasible.
description: 10 pages, 7 figures. Our code is available at http://www.cosmostat.org/software/camelus/ . Published version
Analyzing the Factors Affecting Satisfaction with the Environmentally Friendly Food Assistance Program for Pregnant Women in South Korea
Creators: name: Hong, Yeona
name: Hong, Yeona
Publisher: name: Unknown
Year: 2022
Subjects: subject: Environmental Economics and Policy
subject: Public Economics
subject: Environmentally Friendly Food Assistance Program for Pregnant Women
subject: Environmentally Friendly Food
subject: Beneficiary Satisfaction

description: The purpose of this study is to analyze the factors that affect participants’ satisfaction with the pilot project ‘Environmentally Friendly Food Assistance Program for Pregnant Women’ in 2020 and 2021 and to determine whether the satisfaction increased. We collected the data through an online survey twice in 2021 (962 participants in the pilot project in 2020) and 2022 (1,082 participants in the pilot project in 2021) and used the logistic regression model for the quantitative analysis. As a result of the analysis, it was found that the participants’ satisfaction with the pilot project in 2021 was higher than that in the previous year, which indicates that the project operation method is gradually improving. Factors significantly affecting the overall satisfaction level of the pilot project were participants’ interest in health, food prices and convenience of purchase, and awareness of government policies on the low fertility rate. Respondents who are interested in quality and freshness showed lower satisfaction with the quality of environmentally friendly agricultural products provided through the project, which suggests that it is necessary to continuously improve the quality of the products. Based on the results of this study, it is expected that the central and local governments, which operate the project, will strengthen the aspects with which the beneficiaries were satisfied and actively reflect opinions for improvement, presenting effective program operation directions in the future.
Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone
Creators: name: Shaik, Imam H.
name: Nguyen, Justin H.
name: Montgomery, Donald L.
name: Lemasters, John J.
name: Kobayashi, Eiji
name: Chimalakonda, Anjaneya P.
name: Mehvar, Reza
name: Weidanz, Jon A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The use of methylprednisolone (MP) and other corticosteroids for the treatment of acute liver allograft rejection is associated with severe toxicities in non-target tissues. Therefore, selective delivery of MP to the liver may improve its efficacy and alleviate its side effects. We investigated the effects of a novel liver-targeted dextran prodrug of MP (DMP) in an orthotopic rat liver transplantation (OLT) model.
title: Arbeitsunterbrechungen
Creators: name: Haider, Robert
Year: 2022

description: Um den Zusammenhang zwischen Arbeitsunterbrechungen, unerledigten Aufgaben, individueller Performance und Wohlbefinden nach über einem Jahr des Ausbruchs der COVID-19 Krise und einer nachhaltig veränderten Arbeitslandschaft sowohl im Homeoffice als auch am Standort des Unternehmens zu untersuchen, wurde eine vierwöchige Tagebuchstudie durchgeführt, bei der österreichische Teilnehmer*innen insgesamt N = 192 vollständig verwertbare Tagesdatensätze generierten und zu einem Anteil von knapp über 50% im Homeoffice arbeiteten. Es konnte zum einen gezeigt werden, dass sich Unterbrechungen negativ auf Arbeitsleistung und Wohlbefinden auswirken und dieser Zusammenhang über unerledigte Aufgaben erklärt werden kann und zum anderen, dass dieser mediierende Effekt nicht nur allgemein, sondern auch im Homeoffice Gültigkeit aufweist. Die Befragten gaben an, im Homeoffice weniger unterbrochen worden zu sein als im klassischen Büro-Setting und berichteten weiter eine höhere Arbeitsleistung und besseres Wohlbefinden. Es wurden außerdem 10 potenzielle Umgebungs- und Störfaktoren untersucht und diskutiert, von denen das Telefon bzw. Smartphone und Arbeitskolleg*innen, Vorgesetzte, Freunde und Familie als am störendsten und der Arbeitsleistung am hinderlichsten eingeschätzt wurden, indem sie Arbeitsunterbrechungen begünstigen. Ein explorativ postuliertes Mediationsmodell konnte schließlich zeigen, dass sich die Reduzierung solcher Störquellen über wenigere Unterbrechungen und wenigere unerledigte Aufgaben positiv auf die individuelle Performance und das Wohlbefinden auswirken.
description: To examine the relationship between work interruptions, unfinished tasks, individual work performance, and well-being after more than a year of the onset of the COVID-19 crisis and a sustained change in the work landscape, a four-week diary study was conducted in which Austrian participants generated a total of N = 192 fully usable daily records and worked in the home office at a rate of just over 50%. Not only do work interruptions have a negative impact on work performance and well-being but this correlation can also be explained by unfinished tasks. This mediating effect is both true in general and in the home office. The respondents stated that they were interrupted less in the home office than in the classic office setting and further reported a higher work performance and better well-being. In addition, 10 potential environmental and disruptive factors were investigated and discussed, of which the phone and work colleagues, superiors, friends and family were rated as the most disruptive and the most detrimental to work performance by promoting work interruptions. An exploratory mediation model was finally able to show that the reduction of such sources of disturbance has a positive effect on individual performance and well-being through fewer interruptions and fewer unfinished tasks.
Multiverse Dark Matter: SUSY or Axions
Creators: name: D'Eramo, Francesco
name: Hall, Lawrence J.
name: Pappadopulo, Duccio
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The observed values of the cosmological constant {\it and} the abundance of Dark Matter (DM) can be successfully understood, using certain measures, by imposing the anthropic requirement that density perturbations go non-linear and virialize to form halos. This requires a probability distribution favoring low amounts of DM, i.e. low values of the PQ scale $f$ for the QCD axion and low values of the superpartner mass scale $\tilde{m}$ for LSP thermal relics. In theories with independent scanning of multiple DM components, there is a high probability for DM to be dominated by a single component. For example, with independent scanning of $f$ and $\tilde{m}$, TeV-scale LSP DM and an axion solution to the strong CP problem are unlikely to coexist. With thermal LSP DM, the scheme allows an understanding of a Little SUSY Hierarchy with multi-TeV superpartners. Alternatively, with axion DM, PQ breaking before (after) inflation leads to $f$ typically below (below) the projected range of the current ADMX experiment of $f = (3 - 30) \times 10^{11}$ GeV, providing strong motivation to develop experimental techniques for probing lower $f$.
description: 32 pages, 14 figures, version published on JHEP
title: Die Interdisziplinarität postkolonialer Pädagogik
Creators: name: Stewart, Dayna-Lee
Year: 2022

description: Obwohl die Auseinandersetzung mit Postkolonialismus in der Erziehungs- und Bildungswissenschaft in den letzten Jahren stetig zugenommen hat, besteht weiterhin eine Forschungslücke an Untersuchungen und Studien zu dem Mehrwert und den Erkenntnissen die postkoloniale Theorie der pädagogischen Praxis bietet. Das Ziel der vorliegenden Arbeit ist es herauszufinden ob post-koloniale Pädagogik (in Anlehnung an das Konzept von Patrica Baquero Torres) (2012) sich aufgrund ihrer Interdisziplinarität als fachübergreifender handlungsorientierter Ansatz im kritisch-reflexiven Umgang mit Diskursen der verschiedenen Teildisziplinen der Erziehungs- und Bil-dungswissenschaft eignet. Dazu wird folgende Forschungsfrage gestellt: Inwieweit sind die postkolonialtheoretischen Überlegungen nach Patricia Baquero Torres für verschiedene pädagogische Teildisziplinen relevant? Um die Forschungsfrage zu beantworten, wurde eine kolonialkritische Diskursanalyse von Diskurssträngen aus dem Handbuch „Mehrsprachigkeit und Bildung“ (Gogolin et. al, 2020) durchge-führt. Die Diskursstränge befassen sich mit zentralen Thematiken postkolonialer Pädagogik aus sowohl interkultureller als auch schulischer Perspektive. Die Analysen haben gezeigt, dass postkolonialpädagogische Fragestellungen sich sowohl für dem Umgang mit Mehrsprachigkeit in der interkulturellen Pädagogik als auch in der Schulpädagogik eignen. Obwohl in beiden Fällen kritisch-reflexive und handlungsorientierte Ansätze für den Umgang mit Mehrsprachigkeit herausgearbeitet werden konnten, die sich gut ergänzen, schließt die Forschung nicht konkret auf die Interdisziplinarität postkolonialer Pädagogik. Weiterführende Forschung könnte die pädagogischen Implikationen postkolonialer Theorie für eine erziehungswissenschaftliche Teildisziplin näher untersuchen.