cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Physiological computations underlying our internal representation of vestibular self-motion
Creators: name: Chen, Anthony
Publisher: name: University of British Columbia
Year: 2023

description: Humans, as with other organisms, rely on sensing for survival. The principles implemented by the brain to interpret this sensory information; however, remain open for investigation. The vestibular sense provides information about self-motion and orientation, which in part allows us to properly perceive self-motion in space and to navigate the surrounding environment. The purpose of this thesis was to advance the current knowledge of how the brain processes sensory cues of motion. Because the mechanisms that govern the central integration of vestibular information are difficult to reveal through everyday experiences, we used experimentally controlled sensory stimuli to probe vestibular-related neurophysiological and psychophysical behaviours. Studies presented in this thesis emerge from a first principles approach looking at integration of signals from primary vestibular afferents using a novel sampling-based dynamical inference model. Experiment 1 characterized perceptual self-motion during and following constant vestibular stimulation and contextualized how percepts arise from the integration of differently adapting primary vestibular afferents based on the brain’s expectation about one’s self-motion. Experiment 2 examined why perception changes when different vestibular end-organs encodes the same gravity-neutral whole-body motion. We showed that vestibular otoliths provide the brain additional information of self-rotation, a role primarily attributed to the vestibular semicircular canals. Experiments 3 and 4 together evaluated electrical vestibular stimulation for probing the vestibular system in humans. Here, we used current physiological data of primary vestibular afferent responses to both mechanical and electrical stimuli to predict and evaluate their equivalence in central processing in humans. Subsequently, a real-time solution for human-in-the-loop vestibular sense modulation using electrical vestibular stimulation during active head movements was developed using our identified equivalency. Altogether, this thesis highlights that our perceptions are shaped by our past experiences. Likewise, we show that equivalent perceptual and oculomotor behaviours can be elicited by matching the predicted response of primary vestibular afferents. The novel work presented here offers new theoretical and applied principles about vestibular processing, and the sensory integration process at large. More importantly, this may lead to novel and testable hypotheses for future studies to build upon in both fundamental and clinical areas.
Additional file 1 of NetAct: a computational platform to construct core transcription factor regulatory networks using gene activity
Creators: name: Su, Kenong
name: Katebi, Ataur
name: Kohar, Vivek
name: Clauss, Benjamin
name: Gordin, Danya
name: Qin, Zhaohui S.
name: Karuturi, R. Krishna M.
name: Li, Sheng
name: Lu, Mingyang
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Note 1. TF-target gene set databases. Supplementary Note 2. Processing transcriptomics data. Supplementary Note 3. In silico TF activity inference benchmark. Supplementary Note 4. Construction of the synthetic GRN. Supplementary Note 5. Simulation of activity and expression using RACIPE. Supplementary Note 6. In silico network construction benchmark. Supplementary Note 7. Applications of network modeling with NetAct.
Poecilia reticulata Peters 1859
Creators: name: Ota, Renata Rúbia
name: Deprá, Gabriel de Carvalho
name: Graça, Weferson Júnio da
name: Pavanelli, Carla Simone
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cyprinodontiformes
Poeciliidae
Poecilia
Poecilia reticulata

description: Poecilia reticulata Peters, 1859 Fig. 36 Body elongated; greatest depth contained 3.4 to 4.4 and caudal peduncle depth 4.8 to 6.0 times in SL; head length 3.3 to 4.1, predorsal distance 1.5 to 1.8 and gonopodium length 3.2 to 3.6 in SL; snout length 2.1 to 3.1, horizontal orbital diameter 2.2 to 3.5 and least interorbital width 1.5 to 2.3 in HL. Mouth superior, dentary prognathous; premaxilla and dentary with several small teeth. Longitudinal series with 26- 28 scales and transverse series with 8 or 9 scale rows. Dorsal fin with 8 or 9, pectoral fin with 13 or 14, pelvic fin with 6 and anal fin with 8 or 9 rays. Ground color pale yellow; scales with dark-brown border, conferring reticulate pattern to body; males with several black or colored spots and irregular stripes. Yellowish fins (males with black or colored spots); superior caudal-fin rays prolonged (Graça, Pavanelli, 2007). Maximum standard length. 38.0 mm (Graça, Pavanelli, 2007). Distribution. Drainages from Venezuela to río de la Plata basin. Remarks. Poecilia reticulata is a non-native species from the upper rio Paraná and its occurrence can be associated with its introduction for insect larvae control.
description: Published as part of Ota, Renata Rúbia, Deprá, Gabriel de Carvalho, Graça, Weferson Júnio da & Pavanelli, Carla Simone, 2018, Peixes da planície de inundação do alto rio Paraná e áreas adjacentes: revised, annotated and updated, pp. 1-111 in Neotropical Ichthyology 16 (2) on page 102, DOI: 10.1590/1982-0224-20170094, http://zenodo.org/record/3678395
description: {"references": ["Pavanelli CS, Graca WJ, Zawadzki CH, Britski HA, Vidotti AP, Avelino GS, Verissimo S. Fishes from the Corumba Reservoir, Paranaiba River drainage, upper rio Parana basin, State of Goias, Brazil. Check List. 2007; 3 (1): 58 - 64."]}
Barium extravasation after evacuation proctography causing ischiorectal fossa gangrene
Creators: name: Tonolini, Massimo
Publisher: name: EURORAD
Year: 2014
Subjects: subject: Pelvis
subject: CT
subject: Plain radiographic studies
subject: Contrast agent-other
subject: Diagnostic procedure
subject: Abscess

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 74 years
description: Clinical History: Elderly woman presenting at emergency department complaining of lower abdominal and perineal pain. Eight days before, she had evacuation proctography requested because of difficult evacuation attributed to descending perineum syndrome. Physically she was ... Final Diagnosis: Ischiorectal fossa gangrene from extraperitoneal barium extravasation
Optimizing a potency assay for regulatory T cell therapies
Creators: name: Leung, Macyn
Publisher: name: University of British Columbia
Year: 2023

description: Regulatory T cells (Tregs) are a promising cell therapy for the prevention of immune-mediated pathologies including autoimmune diseases, allergy, transplant rejection and graft versus host disease. Early phase clinical trials have demonstrated Treg adoptive cell transfer to be safe, however the lack of a standardized potency assay to measure the suppressive function of Treg products makes it difficult to compare study results and refine products for optimal in vivo efficacy. Moreover, as clinical trials progress to later phases, potency assays become increasingly desirable by regulatory agencies. In vitro suppression of T cell proliferation is the current gold standard for measuring Treg function, but the current protocols are highly variable. I thus aimed to standardize and optimize a Treg suppression assay and expand on the mechanisms being measured within the in vitro assay. I first optimized the commonly varied steps and reagents such as time of co-culture, activation reagents, media, and types of responder cells that affected assay reproducibility and feasibility. Using Tregs isolated and expanded from discarded human thymus, I then tested the assay’s capacity to distinguish between suppression by activated Tregs versus conventional T cells, and incorporated suppression of B cell CD80 and CD86 expression as one of the assay readouts. I found that the optimal conditions for reproducible responder T cell proliferation was activation for 3 days with Dynabeads Human T-Expander CD3/CD28. Human serum supplementation in serum-free media was necessary for Treg suppression. Measuring suppression of T cell proliferation alone was poorly able to distinguish between suppression mediated by activated Tregs versus competition for resources by activated conventional T cells. However, suppression of CD80 and CD86 on B cells within the assay was Treg-specific. The measurement of CD80 and CD86 suppression on B cells can be readily incorporated into the classic Treg suppression assay and is a more specific measure of Treg function compared to suppression of T cell proliferation. By standardizing the media, activation reagents, and responder cell type, I have generated a robust, Treg-specific suppression assay that brings the field closer to fulfilling the critical need for a potency assay in Treg cell therapies.
Plagioscion squamosissimus
Creators: name: Ota, Renata Rúbia
name: Deprá, Gabriel de Carvalho
name: Graça, Weferson Júnio da
name: Pavanelli, Carla Simone
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Sciaenidae
Plagioscion
Plagioscion squamosissimus

description: Plagioscion squamosissimus (Heckel, 1840) Fig. 36 Body deep; greatest depth contained 2.9 to 3.1, head depth 3.4 to 3.6 and caudal peduncle depth 10.3 to 11.8 times in SL; head length 2.7 to 3.3, predorsal distance 1.5 to 1.8, prepectoral distance 1.7 to 2.2 in SL; snout length 3.7 to 4.2, horizontal orbital diameter 4.2 to 5.6 and least interorbital width 3.6 to 4.9 in HL. Mouth terminal; premaxilla and dentary with several teeth rows. Lateral line with 46-51 pored scales, transverse series above lateral with 12-15 and below lateral line with 15-20 scale rows. Dorsal fin with X,I,29-33, pectoral fin with 15-20, pelvic fin with I,6 and anal fin with II,6 rays. Ground color silvery. Light fins (Graça, Pavanelli, 2007). Maximum standard length. 512.0 mm (Graça, Pavanelli, 2007). Distribution. Amazon, río Orinoco and rio São Francisco basins, and Paraná-Paraguay system (Eschmeyer et al., 2017). Remarks. Plagioscion squamosissimus is a non-native species from the upper rio Paraná and its occurrence can be associated with its introduction due to commercial importance.
description: Published as part of Ota, Renata Rúbia, Deprá, Gabriel de Carvalho, Graça, Weferson Júnio da & Pavanelli, Carla Simone, 2018, Peixes da planície de inundação do alto rio Paraná e áreas adjacentes: revised, annotated and updated, pp. 1-111 in Neotropical Ichthyology 16 (2) on page 102, DOI: 10.1590/1982-0224-20170094, http://zenodo.org/record/3678395
description: {"references": ["Pavanelli CS, Graca WJ, Zawadzki CH, Britski HA, Vidotti AP, Avelino GS, Verissimo S. Fishes from the Corumba Reservoir, Paranaiba River drainage, upper rio Parana basin, State of Goias, Brazil. Check List. 2007; 3 (1): 58 - 64.", "Eschmeyer WN, Fricke R, van der Laan R, editors. Catalog of fishes: genera, species, references [Internet]. San Francisco: California Academy of Science; 2017 [updated 2017 Jan 31; cited 2017 Feb 24]. Available from: http: // researcharchive. calacademy. org / research / ichthyology / catalog / fishcatmain. asp"]}
Additional file 1 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
Creators: name: Chen, Lu
name: Yu, Zhuo
name: Xie, Li
name: He, Xiaoxiao
name: Mu, Xingmei
name: Chen, Chiqi
name: Yang, Wenqian
name: Tong, Xiaoping
name: Liu, Junling
name: Gao, Zhengliang
name: Sun, Suya
name: Xu, NanJie
name: Lu, Zhigang
name: Zheng, Junke
name: Zhang, Yaping
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Hematology
subject: Computational Biology

description: Additional file 1: Figure S1. Related to Fig. 1. Human MAG is a new receptor for ANGPTL2. Figure S2. related to Fig. 2. Murine homologue of human MAG binds to ANGPTL2. Figure S3. Related to Fig. 3. ANGPTL2 promotes oligodendrocyte differentiation. Figure S4. Related to Fig. 4. ANGPTL2 promotes oligodendrocyte differentiation and remyelination under pathological conditions. Figure S5. Related to Fig. 5. ANGPTL2 promotes remyelination via its receptor MAG. Figure S6. Related to Fig. 6. ANGPTL2-MAG induces Fyn-mediated signalling to enhance the differentiation of oligodendrocytes.
Investigating a low number prior in number perception
Creators: name: Long, Miranda
Publisher: name: University of British Columbia
Year: 2023

description: Work in psychology and neuroscience has revealed that human newborns, young children, and many non-human animals are born with the ability to perceive number through the Approximate Number System (ANS), a specialized system for representing number (Xu & Spelke, 2000; Halberda & Feigenson, 2008; Feigenson et al., 2004; Howard et al., 2019). The ANS produces imprecise numeric representations that tend to underestimate the number of objects in a scene or display. This may appear disadvantageous, but if an observer is in a world where objects are more likely to occur in smaller numbers (e.g., 10 cookies, 6 chairs, etc.) compared to larger numbers (e.g., 1,000 bees), then a number system biased towards underestimating the number of objects might be a by-product of the human mind optimally handling the statistics of the real world (Piantadosi, 2016). Here, I utilized a Bayesian inference framework to investigate whether number perception is biased towards lower numbers (i.e., demonstrates a low number prior) given our experiences and expectations (Piantadosi 2016; Testolin et al., 2020). Additionally, I investigated whether this prior gets stronger with age. I presented a wide age range of human participants (e.g., 5-years-old to adults) with a number discrimination task where participants reported which of two sides contains more objects (e.g., “The left side has more dots”). Perceptual noise (e.g., reduced contrast) was embedded in numeric arrays to investigate whether participants were biased by their experiences and expectations for lower numbers when determining which side had more objects. Results revealed the presence of a low number prior, and that the prior does not get stronger with age in the range tested. Taken together, the current research demonstrates that the ANS is likely biased towards lower numbers because of a low number prior. The current research is the first to experimentally test for a low number prior in a wide age range of human participants.
Entrepreneurial Financial Analysis of Access Bank PLC: Current Performance and Future Projections
Creators: name: Silva Opuala-Charles*
name: Adebisi Jack Margaret
name: Nathaniel Sata-Owugha
name: Udoh Ekebo Francis
name: Ikuroaa Daerego E. Jack
Publisher: name: Zenodo
Year: 2024
Subjects: Entrepreneurship; Access Bank; Nigeria; Case Study.

description: Summary: Access Bank PLC's current performance reflects a strategic focus on expansion and growth, underscored by a deliberate and disciplined approach. The bank's financial statements reveal steady progress in key metrics such as return on equity, non-performing loan ratio, cost-to-income ratio, and net interest margin, indicating robust operational efficiency and risk management practices. The bank's expansion strategy, characterized by targeted geographical footprint expansion, particularly in key African markets and global financial gateways, aligns with its goal of becoming a leading aggregator of financial services. By emphasizing risk and earnings diversification, Access Bank aims to maintain Nigeria as its largest market while strategically expanding its presence in other lucrative banking markets to support regional trade. Leveraging partnerships with financial investors and development finance institutions, the bank seeks to enhance strategic support and foster value creation for its stakeholders. Looking ahead, Access Bank's forecasted performance anticipates sustained growth and profitability over the next five years. Projected income statements and balance sheets demonstrate a trajectory of increasing revenues and asset accumulation, driven by continued expansion efforts and strategic initiatives. The bank's discounted cash flow valuation underscores the potential for value creation, reflecting optimism in its ability to generate strong cash flows and deliver attractive returns to investors. With a focus on enhancing operational efficiency, asset quality, and customer-centric services, Access Bank is poised to capitalize on emerging opportunities in the dynamic Nigerian and global financial markets, positioning itself as a leading player in the banking industry.
Additional file 1 of Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS
Creators: name: Tejwani, Vickram
name: Woo, Han
name: Liu, Chen
name: Tillery, Anna K.
name: Gassett, Amanda J.
name: Kanner, Richard E.
name: Hoffman, Eric A.
name: Martinez, Fernando J.
name: Woodruff, Prescott G.
name: Barr, R. Graham
name: Fawzy, Ashraf
name: Koehler, Kirsten
name: Curtis, Jeffrey L.
name: Freeman, Christine M.
name: Cooper, Christopher B.
name: Comellas, Alejandro P.
name: Pirozzi, Cheryl
name: Paine, Robert
name: Tashkin, Donald
name: Krishnan, Jerry A.
name: Sack, Coralynn
name: Putcha, Nirupama
name: Paulin, Laura M.
name: Zusman, Marina
name: Kaufman, Joel D.
name: Alexis, Neil E.
name: Hansel, Nadia N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
Understanding how cannabis use features in the gender experiences of transgender, non-binary and gender non-conforming (TGNC) youth populations
Creators: name: Barborini, Christian
Publisher: name: University of British Columbia
Year: 2024

description: Background and Objectives: Transgender, non-binary and gender non-conforming (herein, “TGNC”) youth (15-24 years old) face overlapping minority stressors (e.g., gender discrimination, lack of access to gender-affirming care, rejection, violence) that contribute to mental health inequities. TGNC youth also use substances at higher rates when compared to cisgender youth, including some of the highest rates of cannabis use in Canada. This thesis will discuss how cannabis use features within the gender experiences of TGNC youth. Methods: This thesis draws on a community-based participatory research approach and photovoice methodology. We conducted in-depth, semi-structured interviews with 27 TGNC youth (15-24 years old) from across British Columbia. Interviews were designed to elicit discussions about the photos youth had taken as well as various gender and mental health experiences related to their cannabis use. Analysis and identification of emergent themes was guided by social constructivist grounded theory as well as queer and trans theorizing and informed by community-based research approaches through regular meetings with our team’s Youth Advisory Committee comprised of TGNC youth who use substances. Results: Three overarching themes pertaining to cannabis use and gender experiences amongst TGNC youth were generated. First, cannabis is purposefully and strategically used by TGNC youth to enact gender expressions and forms of embodiment. Second, cannabis supports introspective thought to mobilize the identity discovery and development of TGNC youth. Finally, cannabis offers a vehicle through which TGNC youth can access moments of gender euphoria and affirmation. Together, these results illustrate that TGNC youth use cannabis based on diverse motivations often related to their shared experience navigating a cisheteropatriarchal society. Conclusions: These findings identify how TGNC youth use cannabis to purposefully and strategically facilitate their mental health, well-being, identity development and self-expression. This research reveals critically important experiential and embodied dimensions of cannabis use that have not historically been considered in cannabis-related policy and the provision of care, including mental health and substance use-related care. Ultimately, these findings underscore the importance of advancing understandings of cannabis use that transcend the confines of the gender binary.
ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.
Creators: name: Sadhu, Lopamudra
name: Tsopoulidis, Nikolaos
name: Hasanuzzaman, Md
name: Laketa, Vibor
name: Way, Michael
name: Fackler, Oliver T
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Model organisms
Biochemistry & Proteomics
Imaging
Signalling & Oncogenes
Cell Biology
Infectious Disease

description: CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3 complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling. Actin polymerization dynamics and filament morphology differ between nucleus and cytoplasm. However, it is unclear how the Arp2/3 complex mediates distinct nuclear and cytoplasmic actin polymerization in response to a common stimulus. In humans, the ARP3, ARPC1, and ARPC5 subunits of the Arp2/3 complex exist as two different isoforms, resulting in complexes with different properties. Here, we show that the Arp2/3 subunit isoforms ARPC5 and ARPC5L play a central role in coordinating distinct actin polymerization events in CD4 T cells. While ARPC5L is heterogeneously expressed in individual CD4 T cells, it specifically drives nuclear actin polymerization upon T cell activation. In contrast, ARPC5 is evenly expressed in CD4 T cell populations and is required for cytoplasmic actin dynamics. Interestingly, nuclear actin polymerization triggered by a different stimulus, DNA replication stress, specifically requires ARPC5 but not ARPC5L. TCR signaling but not DNA replication stress induces nuclear actin polymerization via nuclear calcium-calmodulin signaling and N-WASP. Diversity in the molecular properties and individual expression patterns of ARPC5 subunit isoforms thus tailors Arp2/3-mediated actin polymerization to different physiological stimuli.
Fiber reinforced polymers for seismic retrofitting of structures
Creators: name: Tafheem, Zasiah
name: Nasrin, Sabreena
name: Khusru, Shovona
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400510
subject: Structural engineering

description: ABSTRACT: Many structures located in seismically active zones are not capable of withstanding seismicaction according to current codes and provisions. Significant amount of research work has been carried out inrecent years to develop various strengthening and rehabilitation techniques to improve the seismic perform-ance of structures. Several strengthening methods like addition of new structural elements; external post ten-sioning, steel plate bonding etc. has been applied in the past with varying degree of success. Among thesemethods, seismic retrofit with FRP materials has gain ed notable acceptance from the civil engineeringcommunity in recent years. Retrofitting with FRP materials is now extensively being used as a seismic retro-fitting method all over the world. This paper presents a representative overview of the current state of usingFRP materials as a retrofitting technique for the structures not designed to resist seismic action. It summarizesthe scopes and uses of FRP materials in seismic streng thening of RC structures and masonry retrofitting aswell as the seismic retrofitting schemes for steel structures
(11) (PDF) Fiber reinforced polymers for seismic retrofitting of structures. Available from: https://www.researchgate.net/publication/346097036_Fiber_reinforced_polymers_for_seismic_retrofitting_of_structures [accessed Dec 12 2023]
On the Etymologies of Kypros, kyparissos, kypeiron, kapparis, kypros, kardamon, kardamomon, et al.
Creators: name: Gheorghiu, Alexandru
Publisher: name: Zenodo
Year: 2021
Subjects: Ancient Greek, Pre-Greek, Anatolian, Hittite language, Akkadian language, Sumerian language , Proto-Indo-European linguistics, Indo-European, Sanskrit, Ancient Greece, Cyprus, Bronze Age, Copper, History of copper, History of metallurgy, Eastern Mediterranean, Pelasgian, Eteo-Cypriot, Aegean languages, linguistic anthropology, European history, Greek language, Latin language, Romanian language, German language, English language, Armenian language, Mesopotamia, Semitic languages, Proto-Slavic language, Proto-Balto-Slavic, Burushaski language, Hattic language, Sumer, Akkad, Near East, Kypros, cypress tree, cyperus longus, lawsonia inermis, cress, cardamom, history of spices
Salmoxis, Zalmoxis, Gebeleixis, Zebeleixis, Dacian religion, Thracian religion, Dacian mythology, Thracian mythology, Zibelthiurdos, Zbelsiurdos, Albanian mythology, Thunder god, Lightning god, Storm god, Weather god, Thor, Zeus, Jupiter, Teshub, Cybele, Kybele, Kybebe, Kubaba, Kugbau, Hurrian mythology, Hurrian religion, Sumerian mythology, Sumerian religion, Phrygian religion, Phrygian mythology, Phrygian language, Greco-Roman religion, Greco-Roman mythology, caballus, mountain goddess, gudgeon, history of equine terminology, Peri-Indo-European, Semi-Indo-European, Etymology, Palaeo-Balkan languages, sapphire, salamander, Salamis

description: On the etymologies of Kypros (Cyprus), kyparissos (=the cypress tree), kypeiron (=Cyperus longus), kapparis (the caper plant), kypros (=Lawsonia inermis), kardamom (=Lepidium sativum in Ancient Greek), kardamomon (=Elettaria cardamomum; the plant known in English as cardamom), and many more words and terms. Upcoming versions will discuss additional important semantic progressions observed in a number of languages, semantics which definitely elucidate a number of words in the Proto-Indo-European language and in all Indo-European languages, and in many other languages.
description: Well-augmented and expanded fifth version.
Review of Self-Driving Vehicles
Creators: name: M. A. Baballe
name: Amanatu K.
name: Khadija A. B.
Publisher: name: gjrpublication
Year: 2023

description: In recent years, self-driving cars have drawn a lot of attention. One of the most important aspects of their perception system is real-time object detection. Accurate and timely object detection in a variety of intricate traffic situations is a major obstacle in the development of safe and effective self-driving cars.
ความสัมพันธ์ระหว่างการบริหารความเสี่ยงองค์กรกับการวัดผลองค์กรแบบสมดุลของบริษัทจดทะเบียนในตลาดหลักทรัพย์แห่งประเทศไทย
Creators: name: สนธิญา สุวรรณราช
Publisher: name: คณะวิทยาการจัดการ มหาวิทยาลัยราชภัฏลำปาง
Year: 2563
Subjects: การบริหารความเสี่ยงองค์กร
การวัดผลผลองค์กรแบบสมดุล
บริษัทจดทะเบียนในตลาดหลักทรัพย์แห่งประเทศไทย

description: วารสารวิทยาการจัดการสมัยใหม่, 13, 2, 1-12
A patient-specific treatment technology suite for interstitial gynaecological brachytherapy
Creators: name: Kudla-Hooper, Michael William
Publisher: name: University of British Columbia
Year: 2023

description: Purpose: Delivering conformal treatment plans for high dose rate (HDR) gynaecological (GYN) brachytherapy (BT) using commercially available applicators can be challenging in many clinical cases. The intent of this work is to describe a treatment technology suite developed to enable treatment customization for patients with difficult-to-treat gynaecological malignancies. Methods: A workflow has been created for the creation of patient-specific cylindrical templates (PSCTs), which facilitate preplanned needle trajectories for interstitial (IS) Vaginal HDR-BT. This includes software for design automation, manufacturing processes, and sterilization. The workflow was evaluated for pre-clinical feasibility, including dosimetry, sterilization, and manufacturing quality. The Tandem and Cylinder (T&C) template has been developed for the treatment of cervical malignancies, and has a standard design which can be customized for difficult treatment cases. Both devices were evaluated in treatment cohorts, assessing preplan reproducibility, treatment dosimetry, outcomes, and practicality. A novel, easy-to-use, and fast software algorithm to generate candidate needle trajectory sets for GYN HDR-BT PSCTs is presented. Auto-planned trajectory set-based preplans were compared to original patient preplans for a retrospective patient cohort. Results: Needle trajectories can be exported directly from treatment planning software and converted into a 3D printable PSCT. PSCTs are shown to be manufactured to a clinical quality, and sterilizable. Prospective treatment plans are shown to be equivalent or improved as compared to highly specialized modern techniques. Both treatment cohorts for both PSCTs and T&C patients showed excellent treatment dosimetry, needle position reproducibility, and outcome. Auto-planner-based preplans were of high clinical quality, were equivalent in dosimetry to manually created preplans, and treatment plan libraries were able to be created very quickly. Conclusions: The technology suite developed during this research can be used to successfully preplan and deliver highly conformal treatment plans for IS GYN HDR-BT. The treatment devices are shown to be reliable and to deliver preplans accurately, and to be easy-to-use, compared to traditional treatment techniques. The autoplanning software significantly eases the pre-planning process of the PSCT, without loss of plan quality. This technology suite represents a significant step forward in the personalization of GYN HDR-BT and stands as a platform for future development.
Additional file 3 of ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
Creators: name: Chen, Lu
name: Yu, Zhuo
name: Xie, Li
name: He, Xiaoxiao
name: Mu, Xingmei
name: Chen, Chiqi
name: Yang, Wenqian
name: Tong, Xiaoping
name: Liu, Junling
name: Gao, Zhengliang
name: Sun, Suya
name: Xu, NanJie
name: Lu, Zhigang
name: Zheng, Junke
name: Zhang, Yaping
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Hematology
subject: Computational Biology

description: Additional file 3: Unedited images from gels and western blots.
Discourse structure and language technology
Creators: name: Webber, Bonnie
name: Egg, Markus
name: Kordoni, Valia
Publisher: name: Humboldt-Universität zu Berlin
Year: 2011
Subjects: subject: 004 Informatik
subject: 400 Sprache

description: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
description: An increasing number of researchers and practitioners in Natural Language Engineering face the prospect of having to work with entire texts, rather than individual sentences. While it is clear that text must have useful structure, its nature may be less clear, making it more difficult to exploit in applications. This survey of work on discourse structure thus provides a primer on the bases of which discourse is structured along with some of their formal properties. It then lays out the current state-of-the-art with respect to algorithms for recognizing these different structures, and how these algorithms are currently being used in Language Technology applications. After identifying resources that should prove useful in improving algorithm performance across a range of languages, we conclude by speculating on future discourse structure-enabled technology.
Substrate utilization in the brain and skeletal muscle during environmental and energetic stress in humans
Creators: name: Caldwell, Hannah Grace
Publisher: name: University of British Columbia
Year: 2023

description: Metabolism describes the sum of biochemical reactions that take place within a living organism which provide energy for vital processes; this can be studied at the whole-body, organ specific, or cellular level. Energy availability, which is determined by the difference between energy intake and exercise energy expenditure, is affected by environmental and energetic stresses (e.g., high-altitude, exercise, diet/nutrition). Systemic energy deficits have implications for the regulation of organ-specific substrate utilization and function. The aim of this thesis was to integrate brain, skeletal muscle, and systemic substrate oxidation and relative fuel utilization in the context of selected environmental and energetic stress (high-altitude, exercise, nutritional caloric deficits). Study 1 addressed a fundamental question for integrative cerebrovascular physiology: How are the cerebral metabolic rates of oxygen and glucose utilization (CMRO₂ and CMRGlu, respectively) affected by alterations in arterial PCO₂ (PaCO₂)? The results of this study indicate that cerebral oxidative metabolism (i.e., CMRO₂) is altered by approximately 1 % per mmHg change in PaCO₂. These changes, in part, are explained by an increased compensatory contribution of anaerobic metabolic pathways. Study 2 investigated the research question: How does systemic fuel utilization at high-altitude affect the brain inflammatory response to exercise? The results of this study provide new evidence that 6-8 days of acclimatization at 3,800 m does not provoke immune suppression or exacerbate systemic pro-inflammatory responses at rest or with maximal exercise. Further, altitude-induced alterations in systemic inflammatory responses did not directly affect release of pro-inflammatory cytokines by the brain with maximal exercise. Study 3A showed that 14-days low energy availability (LEA) – involving effectively 50% daily caloric restriction – in endurance-trained females provokes immunological stress, systemic inflammation and impairs exercise performance. Study 3B further revealed that 14-days LEA in these same females provokes an increased reliance on fat oxidation to absolute energy expenditure during submaximal exercise that was independent of any changes in resting metabolic rate, insulin sensitivity, and skeletal muscle mitochondrial respiratory capacity. This dissertation advances our understanding of integrative brain, skeletal muscle, and systemic substrate oxidation and relative fuel utilization in the context of environmental and energetic stress.
GetCoverLetter
Creators: name: Chevalier, Bernard
Publisher: name: Zenodo
Year: 2021
Subjects: job
resume
coverletter

description: GetCoverLetter is managed by a team of career experts. Their common goal is to simplify the job search for candidates. To achieve it, they have created a useful and straightforward cover letter builder for 900+ professions, individual employment tips for each post, a great thematic blog covering current issues of the labor market and application process, and round-the-clock support to quickly assist users with any difficulties or questions. GetCoverLetter
Making kin in image and void : poetics of xiangwang in American ideogrammic poetry
Creators: name: Sang, Cuilin
Publisher: name: University of St Andrews
Year: 2022
Subjects: subject: American poetry
subject: Daoism
subject: Ideogram
subject: Ezra Pound
subject: Marianne Moore
subject: Jorie Graham
subject: Mei-mei Berssenbrugge
subject: Jonathan Stalling
subject: Charles Olson
subject: PS323.5S2
subject: American poetry--20th century--History and criticism
subject: American poetry--Chinese influences
subject: Picture-writing in literature

description: This dissertation explores the connections and mutual enrichment between a daoistically re-viewed American ideogrammic poetry and the poetics of xiangwang 象罔(image and void/web) deriving from early Chinese and Daoist thought. Tracing the gestation of the poetics of xiangwang in this poetic lineage back to Ezra Pound at his metro moment, when he envisioned a poetic medium both as a “pattern” and a “color”, this study discusses two strands of American ideogrammic poetry that are respectively pattern-minded and color-minded. From the perspective of xiangwang, the former is examined as wang-oriented and a poetry of patterned void, that is, a poetry coauthored by a voided heart-mind and a patterning mechanism, whereas the latter is examined as xiang-oriented and a poetry of imaging the unhewn. This study seeks to demonstrate that these poets, via these two poetic avenues with their own idiosyncrasies, are united in their effort to re-shape the English language into an ideogrammic poetic medium, which, through the Daoist lens, can be read as a language of focus and field.
PLATO Conference 2021: Mission, Spacecraft, Payload design
Creators: name: Sacchetti, Andrea
name: Steier, Frank
name: Valenziano, Luca
name: Marliani, Filippo
Publisher: name: Zenodo
Year: 2021
Subjects: PLATO Mission
PLATO Spacecraft
PLATO Payload

description: We describe the design and present status of the different elements of the PLATO Mission, including the overall mission, the spacecraft and the payload.
Research platforms within CIMMYT's innovation hubs and the Latin American Agronomic Research Network (RedAgAL)
Creators: name: Fonteyne, Simon
name: Odjo, Sylvanus
name: Verhulst, Nele
Publisher: name: Zenodo
Year: 2023

description: Agrifood systems in Latin America must find ways to raise farm yields, productivity, and incomes, while
adapting to and mitigating the detrimental effects of climate change and addressing the region's
widespread malnutrition (Govaerts et al., 2021). Myriad efforts to achieve this have offered well-meaning
but short-term, unrealistic, unvalidated, one-size-fits-all responses that fail to solve the actual problems
of farmers across Latin America's highly diverse agroecologies and socioeconomic circumstances. For
instance, smallholder farmers in parts of Mexico continue to practice ancient, traditional milpa intercrops
(Fonteyne et al., 2023), while the country's large-scale commercial farmers embrace the latest
technologies (Verhulst et al., 2011; Romero et al., 2021). The urgent need for extensive agronomic
research that effectively supports farmers under all circumstances far surpasses the capacity of any single
actor and, apart from the Southern Cone countries and Brazil, there is a notable lack of investment in such
research in Latin America. Its difficulty and expense stem partly from the need to conduct it under
conditions that accurately reflect farmers' realities and thus allow them easily to apply the results. To
address the above challenges, CIMMYT leads a network of agricultural field experiments, the Latin
American Agronomic Research Network (Red Latinoamericano de investigación agronómica, RedAgAL).
This paper describes the network and its origins and the methodology of adoption-focused research
platforms within its innovation hubs.
title: Теоретическое наследие С. И. Голода и современные исследования семьи, брака и межпоколенных отношений
Creators: name: Нечаева, Н. А.
name: Бурмыкина, О. Н.
Publisher: name: Реноме
Year: 2020

description: Статья посвящена теоретическому и эмпирическому наследию С. И. Голода — одного из признанных исследователей проблем семьи, брака и сексуальных отношений в отечественной социологии. Авторы стремились показать, что идеи Голода об эволюции семейных отношений, исторических типах семьи, возрастании роли интимности в супружеских и межпоколенных отношениях актуальны в настоящее время и находят прямое отражение в работах современных авторов. Ключевые слова: Сергей Исаевич Голод, эволюционный подход, исторические типы семьи, семья, брак, межпоколенные отношения, супружество, интимность.
Patent protection and access to HIV/AIDS pharmaceuticals in Sub-Saharan Africa.
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 0

description: This report examines the role that patents play in access to pharmaceuticals in the HIV/AIDS crisis of sub-Saharan Africa. The report aims to provide unbiased information about the international patent regime, the current patent status of certain HIV/AIDS drugs in sub-Saharan Africa and opportunities that exist through flexibility in international patent law that may help to improve access to HIV/AIDS drugs in that region. The report concludes that providing state-of-the-art HIV/AIDS therapies to patients in poor countries requires two kinds of subsidies. The first is the indirect subsidy which consumers in developed countries pay in the form of higher prices for patented drugs. The patent incentive in countries such as the United States induces the free market to test and develop new products. Without the patent incentive, life- sustaining AIDS therapies would simply be unavailable even to the wealthiest consumers. The second kind of subsidy is direct funding of the treatment infrastructure and the purchase of drugs for patients in poor countries by the governments of developed countries acting in concert with one another through international programs such as UNAIDS.
Tools for engineering exhaustion-resistant chimeric antigen receptor regulatory T cells in solid organ transplantation
Creators: name: Brown, Andrew William
Publisher: name: University of British Columbia
Year: 2023

description: In solid organ transplantation, the primary challenge is to overcome the alloimmune response that arises from immunological incompatibility between donor and recipient, leading to graft rejection. Current immunosuppressive therapies have significant long-term side effects and seldom achieve graft tolerance. Regulatory T cells (Tregs), critical for self-tolerance and suppressing excessive immune responses, have garnered considerable interest as an adoptive cell therapy in transplantation. One approach to enhance the potency of Treg therapy is to confer donor antigen-specificity by modifying Tregs to express a chimeric antigen receptor (CAR). Specifically, CAR-Tregs targeting MHC class I molecule HLA-A2 have shown prolonged graft survival in several preclinical models and are now entering clinical trials. However, the ability of CAR-Tregs to induce transplant tolerance has yet to be established. Recent experimental evidence has demonstrated that CAR-Tregs are susceptible to exhaustion caused by chronic stimulation, potentially limiting their efficacy. This thesis presents the development of new tools to investigate CAR-Treg exhaustion and to develop exhaustion-resistant CAR-Tregs. The first tool involved the generation of CARs that target MHC class II, expanding the potential targets for CAR-Tregs. A mouse CAR targeting the MHC class II molecule I-Eᵈ was created, and antigen-specific activation and proliferation of Tregs were demonstrated. In addition, hybridomas specific for HLA-DR4 were used to produce a human MHC class II CAR targeting HLA-DR4, and preliminary tests indicated antigen-specific effects in human T cells. These developments lay the groundwork for future research on optimal CAR-Treg targets that minimise Treg exhaustion. The second tool was an in vitro model to study exhaustion in the context of the HLA-A2-targeted CAR. This continuous antigen exposure model employed HLA-A2 expressing artificial antigen-presenting cells and, under optimised parameters, induced T cell dysfunction and an exhaustion-like phenotype in A2 CAR-T cells. This model provides a basis to investigate the transcriptional and epigenetic signature of Treg exhaustion due to chronic CAR stimulation. Together, this research developed tools that can facilitate the evidence-based design of CAR-Tregs, which can improve outcomes in solid organ transplantation.
Appendix A from Crowdsourcing snake identification with online communities of professional herpetologists and avocational snake enthusiasts
Creators: name: Durso, A. M.
name: I. Bolon
name: A. R. Kleinhesselink
name: M. R. Mondardini
name: J. L. Fernandez-Marquez
name: F. Gutsche-Jones
name: C. Gwilliams
name: M. Tanner
name: C. E. Smith
name: W. Wüster
name: F. Grey
name: R. Ruiz De Castañeda
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Species identification can be challenging for biologists, healthcare practitioners and members of the general public. Snakes are no exception, and the potential medical consequences of venomous snake misidentification can be significant. Here, we collected data on identification of 100 snake species by building a week-long online citizen science challenge which attracted greater than 1000 participants from around the world. We show that a large community including both professional herpetologists and skilled avocational snake enthusiasts with the potential to quickly (less than 2 min) and accurately (69–90%; see text) identify snakes is active online around the clock, but that only a small fraction of community members are proficient at identifying snakes to the species level, even when provided with the snake's geographical origin. Nevertheless, participants showed great enthusiasm and engagement, and our study provides evidence that innovative citizen science/crowdsourcing approaches can play significant roles in training and building capacity. Although identification by an expert familiar with the local snake fauna will always be the gold standard, we suggest that healthcare workers, clinicians, epidemiologists and other parties interested in snakebite could become more connected to these communities, and that professional herpetologists and skilled avocational snake enthusiasts could organize ways to help connect medical professionals to crowdsourcing platforms. Involving skilled avocational snake enthusiasts in decision making could build the capacity of healthcare workers to identify snakes more quickly, specifically and accurately, and ultimately improve snakebite treatment data and outcomes.
Los Angeles Times/Verasight: January 2021 Survey
Creators: name: Los Angeles Times
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: President Joe Biden administration will govern for all Americans (1); political compromise and gridlock (2); coronavirus (COVID-19) pandemic (2); racism and policing (4); American Dream (11); ideal community to live in (8); move away from current community (1); voted in 2020 presidential election (1).
Criteria for evaluating the support quality of the OneStop4All (NFDI4Earth Deliverable D2.1.1)
Creators: name: Anders, Ivonne
name: Braesicke, Peter
name: Haßler, Sibylle
name: Kleeberg, Ulrike
name: Ryan, Marie
name: Thiemann, Hannes
Publisher: name: NFDI4Earth Community on Zenodo
Year: 2023
Subjects: NFDI
NFDI4Earth
NFDI4Earth Deliverable
NFDI4Earth Task Area 2
NFDI4Earth 2Facilitate
NFDI4Earth OneStop4All
NFDI4Earth OS4A

description: The OneStop4All (OS4A) is the main access point to all NFDI4Earth resources, and its usability and the quality of the presented content is paramount to the success of the NFDI4Earth. Evaluation of the support quality of the OS4A can be categorised into the usability of the portal website, the subsequent content quality, and the accessible range of topics, and finally the support of the users.
In this first version of the deliverable we describe the preliminary work within the NFDI4Earth expert group "User", the derived criteria, common evaluation schemes and the evaluation methods themselves. We recognise that both the OS4A and the evaluation criteria will need to evolve in tandem, based on the feedback we receive from the community once the OS4A is live.
description: This work has been funded by the German Research Foundation (DFG) through the project NFDI4Earth (DFG project no.460036893, https://www.nfdi4earth.de/) within the German National Research Data Infrastructure (NFDI, https://www.nfdi.de/).