cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Wellbore Strengthening- Nano-Particle Drilling Fluid Experimental Design Using Hydraulic Fracture Apparatus
Creators: name: Nwaoji, Charles Okeibuno
Publisher: name: Graduate Studies
Year: 2012
Subjects: subject: Engineering--Petroleum
subject: Wellbore Strengthening
subject: Nanoparticle
subject: Drilling Fluid
subject: Experimental design
subject: Hydraulic fracture apparatus
subject: Lost circulation
subject: Lost circulation material

description: This research project introduces novel lost circulation material (LCM) drilling fluid blends for both water based mud (WBM) and invert emulsion (diesel oil) based mud (OBM) that have been used successfully in the laboratory to achieve very impressive wellbore strengthening results in both permeable and impermeable formations. The optimal blends consisting of in-house prepared nanoparticles (NP1 and NP2) and standard LCM-graphite were established by running and analyzing laboratory hydraulic fracture tests on Roubidoux sandstone and concrete cores. Different blends were used to induce and seal fractures in the cores. The blends that increased the core fracture breakdown pressure (fbp) the most with minimal distortion in mud rheological properties were selected as optimal blends. The optimal WBM blend increased the core fbp by 70.31% while the optimal OBM blend increased the core fbp by 36.39%. Impermeable concrete tests indicate a positive application of the tested blends in shale formation wellbore strengthening.
Pathogenesis of Renal Fibrosis: a Role for Proteinase-activated Receptor-2
Creators: name: Chung, Hyun Jae
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Pathology
subject: Fibrosis
subject: PAR2
subject: kidney
subject: TGF-beta
subject: CTGF

description: Renal fibrosis is the final manifestation of all progressive chronic kidney disease with a significant morbidity and mortality. However, the underlying mechanisms remain largely unknown. Proteinase-activated Receptor-2 (PAR2) is a G-protein-coupled receptor that is proteolytically activated by serine proteinases such as trypsin. In our in vitro studies, we found that stimulation of PAR2 in human proximal tubular cells with PAR2-activating peptide alone significantly upregulated expression of CCN2 and did so synergistically to augment Transforming growth factor-β (TGF-β)-induced CCN2 production. This synergy was reduced by MAPKinase inhibition. We also found that PAR2 deficiency in mice with unilateral ureteral obstruction (UUO) significantly reduced tubular injuries and fibrosis, and synthesis of renal collagen and α-smooth muscle actin at 7 days post UUO. Our findings demonstrate the potential contribution of PAR2 to renal injury and fibrosis at an early time point due to the ability of PAR2 to augment the production of a profibrotic cytokine.
An Innovative Investigation of the Thermal Environment inside the Reconstructed Caldaria of Two Ancient Roman Baths Using Computational Fluid Dynamics
Creators: name: Oetelaar, Taylor
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: History--Ancient
subject: Computational fluid dynamics
subject: Roman baths
subject: thermal environment
subject: reconstruction
subject: caldarium (room with hot baths)

description: The overarching premise of this dissertation is to use engineering principles and classical archaeological data to create knowledge that benefits both disciplines: transdisciplinary research. Specifically, this project uses computational fluid dynamics (CFD) to analyze the thermal environment inside one room of two Roman bath buildings. By doing so, this research reveals the temperature distribution and velocity profiles inside the room of interest. One of the first preliminary necessities was an accurate measure of the heat input into the room from the radiant heating system. The best way to do this was experimentally. The results showed no dependence on the plenum temperature. The measured convective heat transfer coefficient was between 6.2 and 7.6W/m2.oC, with an average of 7.0W/m2.oC. The CFD analyses begin with a 2-D assessment of the relationship between the windows and doorways of the rooms of interest and their heat retention. The former reinforced the standpoint that the windows had to have glazing to maintain an adequate bathing temperature. The latter suggested that the reason why many doorways were narrow was thermal. The first of two 3-D case studies is a replica small bath for the television series NOVA. The results illustrated that the vault traps the hottest air leaving the region inhabited by the patrons cooler than the average of 35̊C. The data also showed that the open doorway heavily influenced the environment of the room. This influence seemed misleading and the best way to test this was to add the adjoining room and observe the flow patterns. The results of this revealed that the exchange between rooms decreased and the temperature in the room of interest rose to 44̊C. The addition of a cloth door increased the temperature to 49̊C. The second case study—the Baths of Caracalla in Rome—is significantly larger making the simulation of the entire volume impossible. The results showed a greater transitory phase which is due to the self-contained nature of the model. The data also demonstrated a minimal response to the change of season but a dramatic shift with a change to the representation of the sun.
Speckle Temporal Stability in eXtreme Adaptive Optics Coronagraphic Images
Creators: name: Martinez, P.
name: Loose, C.
name: Carpentier, E. Aller
name: Kasper, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The major noise source limiting high-contrast imaging is due to the presence of quasi-static speckles. Speckle noise originates from wavefront errors caused by various independent sources, and it evolves on different timescales pending to their nature. An understanding of quasi-static speckles originating from instrumental errors is paramount for the search of faint stellar companions. Instrumental speckles average to a fixed pattern, which can be calibrated to a certain extent, but their temporal evolution ultimately limit this possibility. This study focuses on the laboratory evidence and characterization of the quasi-static pinned speckle phenomenon. Specifically, we examine the coherent amplification of the static speckle contribution to the noise variance in the scientific image, through its interaction with quasi-static speckles. The analysis of a time series of adaptively corrected, coronagraphic images recorded in the laboratory enables the characterization of the temporal stability of the residual speckle pattern in both direct and differential coronagraphic images. We estimate that spoiled and fast-evolving quasi-static speckles present in the system at the angstrom/nanometer level are affecting the stability of the static speckle noise in the final image after the coronagraph. The temporal evolution of the quasi-static wavefront error exhibits linear power law, which can be used in first order to model quasi-static speckle evolution in high-contrast imaging instruments.
description: A&A accepted
AMPK Promotes Xenophagy Through ‘Priming’ of Autophagic Kinases upon Detection of Salmonella Outer Membrane Vesicles
Creators: name: To, Truc
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2019
Subjects: Autophagy
Cellular signalling
Xenophagy
Infection
Salmonella

description: The autophagy pathway is an essential component of the innate immune response, capable of rapidly targeting intracellular bacteria, which are subsequently degraded by lysosomal enzymes. Recent work has begun to elucidate the regulatory signalling for autophagy induction in response to pathogenic bacteria. However, the initial signalling regulating autophagy induction in response to the detection of pathogens remains largely unclear. Here we report that AMPK, an important upstream activator of the autophagy pathway, is rapidly stimulated upon detection of pathogenic bacteria, prior to bacterial invasion. Bacterial recognition is initially achieved through detection of outer membrane vesicles (OMVs). Additionally, we show that AMPK signalling relieves mTORC1-mediated repression of the autophagy pathway in response to Salmonella infection, positioning the cell for a rapid induction of autophagy. Surprisingly, we found that the activation of AMPK and inhibition of mTORC1 in response to extracellular Salmonella are not accompanied by an induction of bulk autophagy. However, upon Salmonella invasion AMPK signalling is required for efficient and selective targeting of bacteria-containing vesicles by the autophagy pathway through activation of pro-autophagic kinase complexes. Collectively, these results demonstrate a key role for AMPK signalling in coordinating the rapid autophagic response prior to invasion of pathogenic bacteria.
On the origin of [Ne II] emission in young stars: mid-infrared and optical observations with the Very Large Telescope
Creators: name: Baldovin-Saavedra, C.
name: Audard, M.
name: Carmona, A.
name: Guedel, M.
name: Briggs, K.
name: Rebull, L. M.
name: Skinner, S. L.
name: Ercolano, B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: {Abridged version for ArXiv}. We provide direct constraints on the origin of the [Ne II] emission in 15 young stars using high-spatial and spectral resolution observations with VISIR at the VLT that allow us to study the kinematics of the emitting gas. In addition we compare the [Ne II] line with optical forbidden lines observed for three stars with UVES. The [Ne II] line was detected in 7 stars, among them the first confirmed detection of [Ne II] in a Herbig Be star, V892 Tau. In four cases, the large blueshifted lines indicate an origin in a jet. In two stars, the small shifts and asymmetric profiles indicate an origin in a photo-evaporative wind. CoKu Tau 1, seen close to edge-on, shows a spatially unresolved line centered at the stellar rest velocity, although cross-dispersion centroids move within 10 AU from one side of the star to the other as a function of wavelength. The line profile is symmetric with wings extending up to about +-80 km/s. The origin of the [Ne II] line could either be due to the bipolar jet or to the disk. For the stars with VLT-UVES observations, in several cases, the optical forbidden line profiles and shifts are very similar to the profile of the [Ne II] line, suggesting that the lines are emitted in the same region. A general trend observed with VISIR is a lower line flux when compared with the fluxes obtained with Spitzer. We found no correlation between the line full-width at half maximum and the line peak velocity. The [Ne II] line remains undetected in a large part of the sample, an indication that the emission detected with Spitzer in those stars is likely extended.
description: Accepted for publication in Astronomy & Astrophysics; revised version: corrected minor typos, corrected center values (col 3) for CoKuTau1 in Table 5
Formalization and Implementation of Algebraic Methods in Geometry
Creators: name: Marić, Filip
name: Petrović, Ivan
name: Petrović, Danijela
name: Janičić, Predrag
Publisher: name: arXiv
Year: 2012
Subjects: subject: Symbolic Computation (cs.SC)
subject: Logic in Computer Science (cs.LO)
subject: Mathematical Software (cs.MS)
subject: FOS: Computer and information sciences

description: We describe our ongoing project of formalization of algebraic methods for geometry theorem proving (Wu's method and the Groebner bases method), their implementation and integration in educational tools. The project includes formal verification of the algebraic methods within Isabelle/HOL proof assistant and development of a new, open-source Java implementation of the algebraic methods. The project should fill-in some gaps still existing in this area (e.g., the lack of formal links between algebraic methods and synthetic geometry and the lack of self-contained implementations of algebraic methods suitable for integration with dynamic geometry tools) and should enable new applications of theorem proving in education.
description: In Proceedings THedu'11, arXiv:1202.4535
A double detached shell around a post-Red Supergiant:IRAS 17163-3907, the Fried Egg nebula
Creators: name: Lagadec, E.
name: Zijlstra, A. A.
name: Oudmaijer, R. D.
name: Verhoelst, T.
name: Cox, N. L. J.
name: Szczerba, R.
name: Mekarnia, D.
name: van Winckel, H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We performed a mid-infrared imaging survey of evolved stars in order to study the dust distribution in circumstellar envelopes around these objects and to better understand the mass-loss mechanism responsible for the formation of these envelopes. During this survey, we resolved for the first time the circumstellar environment of IRAS 17163-3907 (hereinafter IRAS17163), which is one of the brightest objects in the mid-infrared sky, but is surprisingly not well studied. Our aim is to determine the evolutionary status of IRAS 17163 and study its circumstellar environment in order to understand its mass-loss history. We obtained diffraction-limited images of IRAS 17163 in the mid-infrared using VISIR on the VLT. Optical spectra of the object allowed us to determine its spectral type and estimate its distance via the presence of diffuse interstellar bands. We show that IRAS 17163 is a Post-Red Supergiant, possibly belonging to the rare class of Yellow Hypergiants, and is very similar to the well studied object IRC +10420. Our mid-infrared images of IRAS 17163 are the first direct images of this bright mid-infrared source. These images clearly show the presence of a double dusty detached shell around the central star, due to successive ejections of material with a timescale of the order of 400 years and a total circumstellar mass larger than 4 M$_{\odot}$. This indicates that non quiescent mass-loss occurs during this phase of stellar evolution.
description: Accepted for publication in Astronomy & Astrophysics letters
Morphology of Nematic and Smectic Vesicles
Creators: name: Xing, Xiangjun
name: Shin, Homin
name: Bowick, Mark J.
name: Yao, Zhenwei
name: Jia, Lin
name: Li, Min-Hui
Publisher: name: arXiv
Year: 2011
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Recent experiments on vesicles formed from block copolymers with liquid-crystalline side-chains reveal a rich variety of vesicle morphologies. The additional internal order ("structure") developed by these self-assembled block copolymer vesicles can lead to significantly deformed vesicles as a result of the delicate interplay between two-dimensional ordering and vesicle shape. The inevitable topological defects in structured vesicles of spherical topology also play an essential role in controlling the final vesicle morphology. Here we develop a minimal theoretical model for the morphology of the membrane structure with internal nematic/smectic order. Using both analytic and numerical approaches, we show that the possible low free energy morphologies include nano-size cylindrical micelles (nano-fibers), faceted tetrahedral vesicles, and ellipsoidal vesicles, as well as cylindrical vesicles. The tetrahedral vesicle is a particularly fascinating example of a faceted liquid-crystalline membrane. Faceted liquid vesicles may lead to the design of supra-molecular structures with tetrahedral symmetry and new classes of nano-carriers.
description: 7 pages, 3 figures
A Shannon-Tsallis transformation
Creators: name: Fiori, E. Rufeil
name: Plastino, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: We determine a general link between two different solutions of the MaxEnt variational problem, namely, the ones that correspond to using either Shannon's or Tsallis' entropies in the concomitant variational problem. It is shown that the two variations lead to equivalent solutions that take different appearances but contain the same information. These solutions are linked by our transformation.
Supplementary materials for "Predictors of abnormal Thompson score in term neonates in a tertiary hospital in Zimbabwe"
Creators: name: Khan, Nushrat
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420205
subject: Epidemiological modelling
classificationCode: 420605
subject: Preventative health care

description: These supplementary files include search strings used for the scoping review and the list of selected a priori variables.
The Diophantine equation $b (b+1) (b+2) = t a (a + 1) (a + 2)$ and gap principle
Creators: name: Chan, Tsz Ho
Publisher: name: arXiv
Year: 2024
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11D25

description: In this article, we are interested in whether a product of three consecutive integers $a (a+1) (a+2)$ divides another such product $b (b+1) (b+2)$. If this happens, we prove that there is some gaps between them, namely $b \gg \frac{a \log a)^{1/6}}{\log \log a)^{1/3}}$. We also consider other polynomial sequences such as $a^2 (a^2 + l)$ dividing $b^2 (b^2 + l)$ for some fixed integer $l$. Our method is based on effective Liouville-Baker-Feldman theorem.
description: 9 pages. Period. Math. Hung. (2025)
Roles of Raf-1 kinase in pancreatic beta-cells
Creators: name: Alejandro, Emilyn Uy
Publisher: name: University of British Columbia
Year: 2010

description: A decrease in functional β-cell mass is key in the pathogenesis of both type 1 and type 2 diabetes and in the failure of transplanted islet grafts. Knowledge of the endogenous regulators of β-cell proliferation and survival are important for understanding the physiological regulation of β-cell mass. We have shown that physiological concentrations of the insulin hormone act directly on β-cells to promote proliferation and survival, but its mechanisms remain unclear. We hypothesized that Raf-1, a kinase upstream of both ERK1/2 and Bad, is a critical target of insulin in β-cells. To test this hypothesis, we treated primary β-cells and MIN6 β-cells with multiple insulin concentrations and examined putative downstream targets. Low concentrations of insulin rapidly activated Raf-1 and ERK1/2 in primary islets and MIN6 cells. The phosphorylation of ERK1/2 by insulin was eliminated by exposure to a Raf inhibitor or transfection with a dominant-negative Raf-1 mutant. Insulin enhanced the interaction between mitochondrial Raf-1 and Bad, promoting the inactivation of pro-apoptotic Bad. Over-expression of Raf-1 was sufficient to increase proliferation in the absence of insulin, whereas a dominant-negative Raf-1 reduced proliferation in the presence of insulin. We also tested if Raf-1 signalling plays an important role in β-cell survival both in vitro and in vivo. We utilized a Raf inhibitor and dominant-negative Raf-1 mutants to block basal Raf-1 signalling in serum free conditions in vitro and the Cre-lox recombination system to obtain a β-cell specific deletion of the Raf-1 gene in vivo. Our data show that blocking basal Raf-1 signalling in vitro caused apoptosis. Preliminary data indicate that β-cell specific Raf-1 knockout mice are viable, have increased fasting basal blood glucose levels and have impaired glucose tolerance compared to littermate controls, consistent with the concept that Raf-1 plays an important role in β-cell survival. Together, these findings have significant implications for the understanding of insulin signalling pathway in β-cells and the regulation of β-cell mass.
Porous Superhydrophobic Membranes: Hydrodynamic Anomaly in Oscillating Flows
Creators: name: Rajauria, Sukumar
name: Ozsun, O.
name: Lawall, J.
name: Yakhot, Victor
name: Ekinci, Kamil L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We have fabricated and characterized a novel superhydrophobic system, a mesh-like porous superhydrophobic membrane with solid area fraction $Φ_s$, which can maintain intimate contact with outside air and water reservoirs simultaneously. Oscillatory hydrodynamic measurements on porous superhydrophobic membranes as a function of $Φ_s$ reveal surprising effects. The hydrodynamic mass oscillating in-phase with the membranes stays constant for $0.9\leΦ_s\le1$, but drops precipitously for $Φ_s < 0.9$. The viscous friction shows a similar drop after a slow initial decrease proportional to $Φ_s$. We attribute these effects to the percolation of a stable Knudsen layer of air at the interface.
description: 5 pages, 3 figures
Improving Performance of Low-Rank Matrix Completion Algorithms Through Debiasing of Sampling Patterns
Creators: name: Platonov, Danil
name: Plan, Yaniv
Publisher: name: Zenodo
Year: 2020

description: A solution to low-rank matrix completion is a matrix M of rank r that is much smaller than the dimensions of M and that has to be recovered from a particular sampling of M under the sampling pattern Ω, possibly with noise. This problem has wide applications, such as sensor localization, collaborative filtering and quantum state tomography. This is a well-studied problem in the case of uniform sampling patterns, but little work is done for the non-uniform regime. In this paper we explore possible ways to accelerate state-of-the-art matrix completion algorithms using recent work on debasing simple single-step completion algorithms
Symmetries and the conductance of graphene nanoribbons with long-range disorder
Creators: name: Wurm, J.
name: Wimmer, M.
name: Richter, K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the conductance of graphene nanoribbons with long-range disorder. Due to the absence of intervalley scattering from the disorder potential, time-reversal symmetry (TRS) can be effectively broken even without a magnetic field, depending on the type of ribbon edge. Even though armchair edges generally mix valleys, we show that metallic armchair nanoribbons possess a hidden pseudovalley structure and effectively broken TRS. In contrast, semiconducting armchair nanoribbons inevitably mix valleys and restore TRS. As a result, in strong disorder metallic armchair ribbons exhibit a perfectly conducting channel, but semiconducting armchair ribbons ordinary localization. TRS is also effectively broken in zigzag nanoribbons in the absence of valley mixing. However, we show that intervalley scattering in zigzag ribbons is significantly enhanced and TRS is restored even for smooth disorder, if the Fermi energy is smaller than the potential amplitude. The symmetry properties of disordered nanoribbons are also reflected in their conductance in the diffusive regime. In particular, we find suppression of weak localization and an enhancement of conductance fluctuations in metallic armchair and zigzag ribbons without valley mixing. In contrast, semiconducting armchair and zigzag ribbons with valley mixing exhibit weak localization behavior.
description: 11 pages, 8 figures
Recent photometry of symbiotic stars - XIII
Creators: name: Skopal, A.
name: Shugarov, S.
name: Vanko, M.
name: Dubovsky, P.
name: Peneva, S. P.
name: Semkov, E.
name: Wolf, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present new multicolour (UBVRcIc) photometric observations of classical symbiotic stars, EG And, Z And, BF Cyg, CH Cyg, CI Cyg, V1329 Cyg, TX CVn, AG Dra, Draco C1, AG Peg and AX Per, carried out between 2007.1 and 2011.9. The aim of this paper is to present new data of our monitoring programme, to describe the main features of their light curves and to point problems for their future investigation. The data were obtained by the method of the classical photoelectric and CCD photometry.
description: 39 pages, 16 figures, 16 tables (tables 2-16 are available also in the electronic form)
Analysis of the 2004 Venezuela Referendum: The Official Results Versus the Petition Signatures
Creators: name: Delfino, Gustavo
name: Salas, Guillermo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: On August 15th, 2004, Venezuelans had the opportunity to vote in a Presidential Recall Referendum to decide whether or not President Hugo Chávez should be removed from office. The process was largely computerized using a touch-screen system. In general the ballots were not manually counted. The significance of the high linear correlation (0.99) between the number of requesting signatures for the recall petition and the number of opposition votes in computerized centers is analyzed. The same-day audit was found to be not only ineffective but a source of suspicion. Official results were compared with the 1998 presidential election and other electoral events and distortions were found.
description: Published in at http://dx.doi.org/10.1214/08-STS263 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Magnetically Controlled Accretion Flows onto Young Stellar Objects
Creators: name: Adams, Fred C.
name: Gregory, Scott G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: (abridged) Accretion from disks onto young stars is thought to follow magnetic field lines from the inner disk edge to the stellar surface. The accretion flow thus depends on the geometry of the magnetic field. This paper extends previous work by constructing a collection of orthogonal coordinate systems, including the corresponding differential operators, where one coordinate traces the magnetic field lines. This formalism allows for an (essentially) analytic description of the geometry and the conditions required for the flow to pass through sonic points. Using this approach, we revisit the problem of magnetically controlled accretion flow in a dipole geometry, and then generalize the treatment to consider magnetic fields with multiple components, including dipole, octupole, and split monopole contributions. This approach can be generalized further to consider more complex magnetic field configurations. Observations indicate that accreting young stars have substantial dipole and octupole components, and that accretion flow is transonic. If the effective equation of state for the fluid is too stiff, the flow cannot pass smoothly through the sonic points in steady state. For a multipole field of order \ell, we derive a constraint on the polytropic index, n>\ell+3/2, required for steady transonic flow to reach free-fall velocities. For octupole fields, inferred on surfaces of T Tauri stars, n>9/2, so that the flow must be close to isothermal. The inclusion of octupole field components produces higher densities at the stellar surface and smaller hot spots, which occur at higher latitudes; the magnetic truncation radius is also modified. This contribution thus increases our understanding of magnetically controlled accretion for young stellar objects and can be applied to a variety of additional astrophysical problems.
description: 50 pages, 8 figures, accepted to ApJ
Checklist for national policymakers: 4 steps to implement a national rights retention policy
Creators: name: Ignasi Labastida
name: Iva Melinščak Zlodi
name: Vanessa Proudman
name: Clara Riera
name: Jon Treadway
Publisher: name: Zenodo
Year: 2023
Subjects: Rights retention
Policy implementation
Open Access
Checklist
National policymakers
Infographic

description: This checklist is to support national policymakers. It is part of the RetainYourRights campaign from Project Retain, led by SPARC Europe as part of the Knowledge Rights 21 Programme.

This project was funded by Arcadia – a charitable fund of Lisbet Rausing and Peter Baldwin.
Optimal Filtration and a Pulsar Time Scale
Creators: name: Rodin, A. E.
name: Chen, Ding
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: An algorithm is proposed for constructing a group (ensemble) pulsar time based on the application of optimal Wiener filters. This algorithm makes it possible to separate the contributions of variations of the atomic time scale and of the pulsar rotation to barycentric residual deviations of the pulse arrival times. The method is applied to observations of the pulsars PSR B1855+09 and PSR B1937+21, and is used to obtain corrections to UTC relative to the group pulsar time PT$_{\rm ens}$. Direct comparison of the terrestrial time TT(BIPM06) and the group pulsar time PT$_{\rm ens}$ shows that they disagree by no more than $0.4\pm 0.17\; μ$s. Based on the fractional instability of the time difference TT(BIPM06) -- PT$_{\rm ens}$, a new limit for the energy density of the gravitational-wave background is established at the level $Ω_g {h}^2\sim 10^{-9}$.
description: 12 pages, 4 figures; ISSN 1063-7729
Renormalization group evolution of multi-gluon correlators in high energy QCD
Creators: name: Dumitru, Adrian
name: Jalilian-Marian, Jamal
name: Lappi, Tuomas
name: Schenke, Bjoern
name: Venugopalan, Raju
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Many-body QCD in leading high energy Regge asymptotics is described by the Balitsky-JIMWLK hierarchy of renormalization group equations for the x evolution of multi-point Wilson line correlators. These correlators are universal and ubiquitous in final states in deeply inelastic scattering and hadronic collisions. For instance, recently measured di-hadron correlations at forward rapidity in deuteron-gold collisions at the Relativistic Heavy Ion Collider (RHIC) are sensitive to four and six point correlators of Wilson lines in the small x color fields of the dense nuclear target. We evaluate these correlators numerically by solving the functional Langevin equation that describes the Balitsky-JIMWLK hierarchy. We compare the results to mean-field Gaussian and large N_c approximations used in previous phenomenological studies. We comment on the implications of our results for quantitative studies of multi-gluon final states in high energy QCD.
description: 8 pages, 7 figures
Block-based Bayesian epistasis association mapping with application to WTCCC type 1 diabetes data
Creators: name: Zhang, Yu
name: Zhang, Jing
name: Liu, Jun S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Interactions among multiple genes across the genome may contribute to the risks of many complex human diseases. Whole-genome single nucleotide polymorphisms (SNPs) data collected for many thousands of SNP markers from thousands of individuals under the case--control design promise to shed light on our understanding of such interactions. However, nearby SNPs are highly correlated due to linkage disequilibrium (LD) and the number of possible interactions is too large for exhaustive evaluation. We propose a novel Bayesian method for simultaneously partitioning SNPs into LD-blocks and selecting SNPs within blocks that are associated with the disease, either individually or interactively with other SNPs. When applied to homogeneous population data, the method gives posterior probabilities for LD-block boundaries, which not only result in accurate block partitions of SNPs, but also provide measures of partition uncertainty. When applied to case--control data for association mapping, the method implicitly filters out SNP associations created merely by LD with disease loci within the same blocks. Simulation study showed that this approach is more powerful in detecting multi-locus associations than other methods we tested, including one of ours. When applied to the WTCCC type 1 diabetes data, the method identified many previously known T1D associated genes, including PTPN22, CTLA4, MHC, and IL2RA.
description: Published in at http://dx.doi.org/10.1214/11-AOAS469 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Automated Generation of User Guidance by Combining Computation and Deduction
Creators: name: Neuper, Walther
Publisher: name: arXiv
Year: 2012
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Human-Computer Interaction (cs.HC)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: D.3.2; F.4.1; I.2.3; I.2.2; I.2.3; I.2.5

description: Herewith, a fairly old concept is published for the first time and named "Lucas Interpretation". This has been implemented in a prototype, which has been proved useful in educational practice and has gained academic relevance with an emerging generation of educational mathematics assistants (EMA) based on Computer Theorem Proving (CTP). Automated Theorem Proving (ATP), i.e. deduction, is the most reliable technology used to check user input. However ATP is inherently weak in automatically generating solutions for arbitrary problems in applied mathematics. This weakness is crucial for EMAs: when ATP checks user input as incorrect and the learner gets stuck then the system should be able to suggest possible next steps. The key idea of Lucas Interpretation is to compute the steps of a calculation following a program written in a novel CTP-based programming language, i.e. computation provides the next steps. User guidance is generated by combining deduction and computation: the latter is performed by a specific language interpreter, which works like a debugger and hands over control to the learner at breakpoints, i.e. tactics generating the steps of calculation. The interpreter also builds up logical contexts providing ATP with the data required for checking user input, thus combining computation and deduction. The paper describes the concepts underlying Lucas Interpretation so that open questions can adequately be addressed, and prerequisites for further work are provided.
description: In Proceedings THedu'11, arXiv:1202.4535
title: SGI 2024 Codebook
title: Sustainable Governance Indicators
titleType: Subtitle
Creators: name: Schiller, Christof
name: Hellmann, Thorsten
Publisher: name: Bertelsmann Stiftung
Year: 2023
Subjects: Nachhaltigkeit
Regierung
Monitoring
Indikatoren

description: The Paris Agreement serves as a global framework with the aim of averting perilous climate change. Its primary objectives are to limit global warming to a level significantly below 2°C and to strive for even greater efforts to keep the increase in temperature below 1.5°C (UNFCCC 2015). However, recent projections paint a worrisome picture, revealing that the collective commitments made by nations are still falling far short of the actions required to implement effective carbon removal strategies and curb greenhouse gas emissions by 2030 (Boehm et al. 2022).
Strong Response of the very broad h$β$ Emission Line in Luminous Radio-Quite Quasar pg1416-129
Creators: name: Wang, J.
name: Li, Y.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We report new spectroscopic observations performed in 2010 and 2011 for luminous radio-quite quasar PG 1416-129. Our new spectra with high quality cover both H$β$ and H$α$ regions, and show negligible line profile variation within a timescale of one year. The two spectra allow us to study the variability of the Balmer line profile by comparing the spectra with the previous ones taken at 10 and 20 years ago. By decomposing the broad Balmer emission lines into two Gaussian profiles, our spectral analysis suggests a strong response to the continuum level for the very broad component, and significant variations in both bulk blueshift velocity/FWHM and flux for the broad component. The new observations additionally indicate flat Balmer decrements (i.e., too strong H$β$ emission) at the line wings, which is hard to be reproduced by recent optically thin models. With these observations we argue that a separate inner optically thin emission-line region might not be necessary in the object to reproduce the observed line profiles.
description: Accepted by ApJL, 14 pages, 3 figures, and 1 table
The architectural research of the belfry of the church of St James the Apostle in Sandomierz
Creators: name: Doroz-Turek, Małgorzata
Publisher: name: Faculty of Architecture, Wrocław University of Technology, Wrocław
Year: 2018
Subjects: Dominicans, Middle Ages, architecture, belfry, church of St James the Apostle, Sandomierz

description: ARCHITECTUS; ISSN 1429-7507
Physicians of Conscience: A Narrative Inquiry with Canadian Abortion Providers
Creators: name: Shaw, Jessica
Publisher: name: Graduate Studies
Year: 2015
Subjects: subject: Social Work
subject: FOS: Sociology
subject: WomenÕs Studies
subject: Medicine and Surgery
subject: abortion
subject: abortion providers
subject: physicians
subject: Social Work
subject: conscience
subject: narrative inquiry
subject: stories

description: The landscape of abortion provision in Canada is complex and features many competing stories. Despite the fact that abortion has been fully decriminalized in Canada since 1988, debates about the morality of abortion continue. Within the abortion literature and scholarship, the perspectives of abortion providers are rarely presented. This study is a narrative inquiry that explored, in depth, the experiences of four physicians who provide abortion care in Canada. Narrative inquiry proceeds from an ontological commitment to experience, making it a useful means to deeply explore the experiences of abortion providers. In this inquiry, stories of abortion provision were lived and told alongside stories of being a mother, a daughter, a friend, a partner, and a woman. Four narrative accounts in this dissertation evoke the ways in which the participants composed themselves as abortion providers. Each of these accounts speaks to the complexities, tensions, and possibilities for understanding abortion provision. Although each narrative account is an individual story, the participants’ stories meet each other at key moments, and in ways that enable the weaving of what are termed narrative threads. These threads are moments of conversation between the stories; they are commonalities and resonances that help to consider participants’ narrative accounts in the context of broader conversations about abortion provision. Seven narrative threads are presented in this dissertation. This inquiry argues for abortion as a critical social justice issue that has social work implications, and frames abortion providers as physicians of conscience; as practitioners who think about things with intention, have morality, and act purposefully. At a time when conscientious objection is being used so readily to refuse people the sexual and reproductive health care that they need, it is especially important to use reasons of conscience to affirm the provision of abortion care. The stories in this dissertation can inform both abortion advocates, as well as those who oppose abortion, by introducing new, or at least different, ways of thinking about the experiences of abortion providers. This dissertation concludes with reflections on the process of narrative inquiry and makes recommendations for research and social work policy and practice.
Reduplicated MWE (RMWE) helps in improving the CRF based Manipuri POS Tagger
Creators: name: Nongmeikapam, Kishorjit
name: Nonglenjaoba, Lairenlakpam
name: Nirmal, Yumnam
name: Bandyopadhyay, Sivaji
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7

description: This paper gives a detail overview about the modified features selection in CRF (Conditional Random Field) based Manipuri POS (Part of Speech) tagging. Selection of features is so important in CRF that the better are the features then the better are the outputs. This work is an attempt or an experiment to make the previous work more efficient. Multiple new features are tried to run the CRF and again tried with the Reduplicated Multiword Expression (RMWE) as another feature. The CRF run with RMWE because Manipuri is rich of RMWE and identification of RMWE becomes one of the necessities to bring up the result of POS tagging. The new CRF system shows a Recall of 78.22%, Precision of 73.15% and F-measure of 75.60%. With the identification of RMWE and considering it as a feature makes an improvement to a Recall of 80.20%, Precision of 74.31% and F-measure of 77.14%.
description: 15 pages, 4 tables, 2 figures, the link http://airccse.org/journal/jcsit/1011csit05.pdf. arXiv admin note: text overlap with arXiv:1111.2399
Microbial Ecology of Carbon Steel Corrosion
Creators: name: Mand, Jaspreet
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Microbial activity in oil and gas environments can pose significant challenges for petroleum production. One of the most well-characterized problems is the anaerobic corrosion of carbon steel infrastructure involving sulfate reducing bacteria (SRB). Several mechanisms have been proposed for microbially influenced corrosion (MIC) by SRB. However there remains a lack of knowledge regarding MIC caused by other microorganisms. In recent years, improved genomic technologies are allowing for the characterization of diversity of microbial communities in field samples. These molecular techniques show that while SRB form a fraction of the community associated with corrosion failures, many other microorganisms are also present. In this dissertation these genomic methods were used to characterize several different environmental samples. From these data, MIC mechanisms were hypothesized and tested in laboratory studies. This led to a new biocorrosion model under anaerobic conditions where hydrogenotrophic acetogens (Acetobacterium), hydrogenotrophic methanogens (family Methanobacteriaceae) and acetotrophic methanogens (Methanosaeta) are growing together. In following experiments, we found that carbon steel was preferentially used over oil organics as an electron donor for communities containing methanogenic and acetogenic microorganisms. This community-based MIC model was expanded upon in subsequent experiments where enhanced activity of hydrogenotrophic organisms was seen in the presence of sulfide and carbon steel. In another environment, bisulfite-disproportionating bacteria (Desulfocapsa) were linked to corrosive sulfur formation in water pipelines. Finally the genomics approach was used to identify several sulfur-cycling microorganisms that were potentially associated with MIC in seawater environments. Through this work, a better understanding of how microbial communities are impacting MIC in different steel-containing environments has been gained. This work has also shown how corrosion mitigation strategies can impact microbial growth. This knowledge can be used to develop monitoring and mitigation schemes to limit MIC associated failures, which would be of great benefit from safety, economic and environmental points of view.
Exploring The Potential of Metabo-Endotypes Using Plasma in Early Phase Herbal Trials: A Phase 1, Single-Centre, Open-Labelled, Randomized-Controlled, Oral Administration of Andrographis paniculata Capsules Pharmacometabolomic Study in Health Volunteers
Creators: name: Boon, TEE Khim
name: Hasniza, ZAMAN HURI
name: IBRAHIM Luqman
name: Najihah, MOHD HASHIM
name: Zuwairi, SAIMAN Mohd
name: Harza, ZAKARIA Zaril
name: SAKIKA Kasful Asra
name: HISHAM Syaza Fatnin
name: MANSOR Azwa
Publisher: name: Zenodo
Year: 2021
Subjects: pharmacometabolomics
Andrographis paniculata
herbal medicine
metabo-endotypes

description: Introduction:
 Metabo-endotypes is defined as a distinct functional or pathobiological mechanism from a subtype of condition derived via metabolomic profiling. Early phase clinical trials aim to profile the pharmacokinetics and explore the pharmacodynamics of medicines. Application of pharmacometabolomics in early phase clinical trials provide insights of significant metabo-endotypes that produce biological perturbation of the drug in human. Andrographis paniculata (AP) is a well-known herbal medicine that contained multi-phytochemicals which have been registered for traditional use in different doses. In this work, metabolomics is proposed to explore the pharmacodynamic effects of AP capsules in 1000mg and 2000mg doses. Methodology:
 The trial is approved by ethics committee and registered with NMRR and ClinicalTrials.gov. Eligible subjects were randomized to either 1000mg or 2000mg of AP capsules. Plasma samples were collected from subjects to analyse using high resolution liquid chromatography mass spectrometry with C18 column. The data were processed in MetaboAnalyst to perform principal component analysis, fold change, t-test and volcano plot to identify significant features. The significant features were paired with knowledge-driven database to identify possible human metabolic pathways. Results:
 At peak plasma time points, AP 1000mg demonstrate significant in carnitine shuttle metabolic pathways in the positive mode. Purine metabolism and leukotriene metabolism are profound in the negative mode. For AP 2000mg, carnitine shuttle remained significant metabolic pathway with higher compound hits in the positive mode, arachidonic acid metabolism and glycosphingolipid metabolism are mainly observed in negative mode. Discussion/ Conclusion:
 Pharmacometabolomics can derived the metabo-endotypes with pharmacological effects to provide insights of the pharmacological pathways for medicines. Disclaimer: Abstract text might vary slightly from what is displayed in the e-poster.
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) in August 18-20, 2021. https://nccrconference.com.my/
Nonlinear optical bistability in microring resonators for enhanced phase sensing
Creators: name: Tritschler, Patrick
name: Schweikert, Christian
name: Klenk, Rouven H.
name: Abdani, Simon
name: Sözen, Onur
name: Vogel, Wolfgang
name: Rademacher, Georg
name: Ohms, Torsten
name: Zimmermann, André
name: Degenfeld-Schonburg, Peter
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Photonic microring resonators are used in a variety of chip-integrated sensing applications where they allow one to measure transmission intensity changes upon external signals with a sensitivity that scales linearly with the Q factor. In this work, we suggest exploiting the nonlinear self-phase-modulation effect to increase the overall sensitivity by an additional gain factor appearing when the operational point of the nonlinear resonator is chosen just at the crossover from the monostable to the bistable regime. We present the theoretical idea together with a first proof of concept experiment displaying a gain factor of 22 on a chip-integrated silicon-nitride resonator.