cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genomic Study of High-Risk Clones of Enterobacter hormaechei Collected from Tertiary Hospitals in the United Arab Emirates
Creators: name: Ghazawi, Akela
name: Anes, Febin
name: Mouftah, Shaimaa
name: Elbediwi, Mohammed
name: Baig, Awase
name: Alketbi, Muna
name: Almazrouei, Fatema
name: Alhashmi, Mariam
name: Alzarooni, Norah
name: Manzoor, Ashrat
name: Habib, Ihab
name: Strepis, Nikolaos
name: Nabi, Anju
name: Khan, Mushtaq
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Enterobacter hormachei
subject: MDR
subject: whole-genome sequencing
subject: plasmids
subject: incompatibility types
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Enterobacter hormaechei has emerged as a significant pathogen within healthcare settings due to its ability to develop multidrug resistance (MDR) and survive in hospital environments. This study presents a genome-based analysis of carbapenem-resistant Enterobacter hormaechei isolates from two major hospitals in the United Arab Emirates. Eight isolates were subjected to whole-genome sequencing (WGS), revealing extensive resistance profiles including the blaNDM-1, blaOXA-48, and blaVIM-4 genes. Notably, one isolate belonging to ST171 harbored dual carbapenemase genes, while five isolates exhibited colistin resistance without mcr genes. The presence of the type VI secretion system (T6SS), various adhesins, and virulence genes contributes to the virulence and competitive advantage of the pathogen. Additionally, our isolates (87.5%) possessed ampC β-lactamase genes, predominantly blaACT genes. The genomic context of blaNDM-1, surrounded by other resistance genes and mobile genetic elements, highlights the role of horizontal gene transfer (HGT) in the spread of resistance. Our findings highlight the need for rigorous surveillance, strategic antibiotic stewardship, and hospital-based WGS to manage and mitigate the spread of these highly resistant and virulent pathogens. Accurate identification and monitoring of Enterobacter cloacae complex (ECC) species and their resistance mechanisms are crucial for effective infection control and treatment strategies.
title: Plan for the Use of Findings for Decision-making and Refinement of Program
Creators: name: Evans, David R.
name: Rossman, Gretchen
name: Sahni, Urvashi
Publisher: name: University of Massachusetts Amherst
Year: 1999
Subjects: subject: India
subject: Uttar Pradesh
subject: gender and education
subject: teacher training
subject: Education
subject: Elementary Education and Teaching
subject: Teacher Education and Professional Development

description: The project, Strengthening the Education of Girls in India, was designed in 1995 through a collaborative effort of USAID officials and Indian nationals who are experts in girls' and women's education. In the three and one-half years since the project was designed, changes have occurred in the climate of support for and thinking about girls' education in India generally and the state of Uttar Pradesh specifically. this document describes salient elements of that changing context and discusses how the project will respond to them. The document also describes how findings thus far from project implementation will shape refinement of the project.
title: Music Box: Jim Larranaga, ca. 2006
Creators: name: University, George Mason
Publisher: name: George Mason University
Year: 2006
Subjects: subject: George Mason University
subject: Basketball
subject: Larranaga, Jim
subject: Music box

description: Music Box: color, closed - 3.25" x 3.25" (8.25 cm x 8.25 cm); open - 3.25" x 5" (8.25 cm x 12.7 cm)
description: Mason Patriots music box with "pop-up" figure of Mason Head Coach Jim Larranaga. The item, sponsored by the Meltzer Group, was distributed during the Mason Homecoming game with Towson University on February 11, 2006. 2005-06 Men's Basketball Season and Tournament Run Collection Box 3
Αναδρομική μελέτη συσχέτισης των δερματοστιξιών με την αιτία και τις συνθήκες επέλευσης του θανάτου
Creators: name: Παπαρίδου, Βασιλική Λεόντιου
Publisher: name: Aristotle University of Thessaloniki
Year: 2024
Subjects: Τατουάζ
Δερματοστιξία
Νεκροτομή
Αιτία θανάτου
Είδος θανάτου
Ιατροδικαστική
Tattoo
Autopsy
Cause of death
Manner of death
Forensic pathology

description: Η παρούσα διπλωματική εργασία επικεντρώνεται στη διερεύνηση της συσχέτισης των δερματοστιξιών με την αιτία, το είδος και τις συνθήκες επέλευσης του θανάτου σε περιπτώσεις ατόμων όπου διενεργήθηκε νεκροψία-νεκροτομή. Η έρευνα βασίζεται σε ιατροδικαστικές υποθέσεις οι οποίες εξετάσθηκαν στο Εργαστήριο Ιατροδικαστικής και Τοξικολογίας της Ιατρικής Σχολής του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών κατά τη χρονική περίοδο 2016 – 2021. Το τατουάζ αντιπροσωπεύει ένα σύμβολο της ατομικής και πολιτιστικής ταυτότητας και αντανακλάται στην ανθρώπινη ιστορία για χιλιάδες χρόνια. Στο πλαίσιο της έρευνας, παρέχεται μια σύντομη επισκόπηση της ιστορίας της δερματοστιξίας και παρουσιάζεται μια συνοπτική ιστορική διαδρομή της διαδικασίας της αφαίρεσης του τατουάζ. Πέραν αυτού, εξερευνώνται οι ιατροδικαστικές και οι επιστημονικές πτυχές που σχετίζονται με τη στίξη. Στο δεύτερο κεφάλαιο, παρουσιάζεται ο σκοπός της εργασίας, ενώ στο τρίτο κεφάλαιο αναλύεται λεπτομερώς το υλικό, η μεθοδολογία και η στατιστική επεξεργασία των δεδομένων που χρησιμοποιήθηκαν. Στο τέταρτο κεφάλαιο παρουσιάζονται τα αποτελέσματα που προέκυψαν από τη στατιστική επεξεργασία των δεδομένων, ενώ το τελευταίο μέρος της εργασίας είναι αφιερωμένο στη σύγκριση των αποτελεσμάτων με προηγούμενες έρευνες και στα συμπεράσματα που προέκυψαν από την παρούσα διπλωματική εργασία.
description: The present dissertation focuses on investigating the correlation between tattoos and the cause, manner and circumstances of death in cases where autopsies examinations were conducted. The research is based on forensic cases examined at the Department of Forensic Medicine and Toxicology of the Medical School at the National and Kapodistrian University of Athens during the period 2016 – 2021. Tattoos represent a symbol of individual and cultural identity, reflecting in human history for thousands of years. Within the scope of the research, a brief overview of the history of tattooing is provided, along with a concise historical trajectory of the tattoo removal process. Additionally, the forensic and scientific aspects related to tattooing are explored. In the second chapter, the purpose of the dissertation is presented, while the third chapter provides a detailed analysis of the material, methodology and statistical analysis of the data, while the last section of the study, is dedicated to comparing the findings with previous research and discussing the conclusions drawn from the present dissertation.
description: Διιδρυματικό με τη συμμετοχή του Τμήματος Ιστορίας και Εθνολογίας της Σχολής Κλασικών και Ανθρωπιστικών Σπουδών του Δημοκρίτειου Πανεπιστημίου Θράκης.
The unbearable lightness of objects: Günter Figal’s spatial aesthetics
Creators: name: AbuSehly, Karam
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Günter Figal
subject: phenomenological-hermeneutical philosophy
subject: aesthetics
subject: appearance
subject: spatiality
subject: objectivity
subject: 100 Philosophie und Psychologie::100 Philosophie::102 Verschiedenes

description: The main work of philosopher Günter Figal (1949–2024) was to undertake the continuation of hermeneutical philosophy after the deaths of its three major proponents: Heidegger, Gadamer, and Ricoeur. Figal’s philosophical project combines both phenomenology and hermeneutics and presents the task of philosophy as being essentially hermeneutical. He also proposes that aesthetics is phenomenology, as nothing is more phenomenal than the work of art, which is out there to be interpreted. His contribution to aesthetics is generally based on his notions of the objectivity [Gegenständlichkeit] and spatiality of artworks. The objectivity of artworks makes obvious their spatiality, and space makes the objectness of the art object most apparent. Both objectivity and spatiality are also essential to the hermeneutics of art. Figal’s contribution to aesthetics, however, is underexplored. The present study thus aims to undertake a conceptual analysis of Figal’s contributions to aesthetics, especially his concepts of objectivity [Gegenständlichkeit] and spatiality of art. In so doing, the present study aims to present an account of Figal’s aesthetics, highlighting its place in the German aesthetic tradition.
How to see stress in chickens: On the way to a Stressed Chicken Scale
Creators: name: Schlegel, Larissa
name: Kleine, Anne S.
name: Doherr, Marcus G.
name: Fischer-Tenhagen, Carola
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: animal welfare
subject: laboratory animal
subject: chicken
subject: poultry
subject: noninvasive stress assessment
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: For many species, scales are used to classify discomfort and stress (e.g., facial expression/pain scales). Although a significant number of vertebrates used for scientific purposes are chickens, a corresponding scale for birds has not yet been established. We developed a Stressed Chicken Scale (SCS) to investigate whether it is possible to assess discomfort in a chicken by its body posture. A selective review with additional handsearch was conducted to find suitable parameters for visual stress assessment. Seven potential body signals were identified: Tail and head position, eye closure, beak opening, leg and wing position, and plumage fullness (ruffled or fluffed up feathers). The SCS was evaluated for interobserver reliability with veterinary students (n = 20), using randomized pictures of stressed and unstressed chickens in lateral view (n = 80). Observers were able to identify the body signals on the pictures after a brief training session. Agreement scores for interobserver agreement ranged from κ = 0.31 (fair agreement) for eye closure to κ = 0.78 (substantial agreement) for beak opening. We found that the number of body signals displayed in a stressed expression had an impact on observers' overall assessment of the chickens, for example, chickens were more likely to be rated as stressed if more than 4 signals indicative of stress were present. We conclude that the 7 individual body signals can be used to identify discomfort in chickens.
Evolutionary Dynamics of Accelerated Antiviral Resistance Development in Hypermutator Herpesvirus
Creators: name: Höfler, Thomas
name: Nascimento, Mariana Mara
name: Zeitlow, Michaela
name: Kim, Ji Yoon
name: Trimpert, Jakob
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: antiviral resistance
subject: hypermutation
subject: experimental evolution
subject: accelerated
subject: HSV-1
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Antiviral therapy is constantly challenged by the emergence of resistant pathogens. At the same time, experimental approaches to understand and predict resistance are limited by long periods required for evolutionary processes. Here, we present a herpes simplex virus 1 mutant with impaired proofreading capacity and consequently elevated mutation rates. Comparing this hypermutator to parental wild type virus, we study the evolution of antiviral drug resistance in vitro. We model resistance development and elucidate underlying genetic changes against three antiviral substances. Our analyzes reveal no principle difference in the evolutionary behavior of both viruses, adaptive processes are overall similar, however significantly accelerated for the hypermutator. We conclude that hypermutator viruses are useful for modeling adaptation to antiviral therapy. They offer the benefit of expedited adaptation without introducing apparent bias and can therefore serve as an accelerator to predict natural evolution.
title: The Creative Economy and its Developmental Dimensions in the United Arab Emirates
Creators: name: Zidan, Ahmed Adel
Publisher: name: National Library and Archives
Year: 2023
Subjects: Cultural Industries - United Arab Emirates
Creativity in Culture - United Arab Emirates

 This research paper discusses common topics and concepts (creative economy, cultural economy, creative and cultural industries, and the creative class) that have captured the attention of the world. The idea and investment opportunities have become the core of the new economy, where "the world is shifting towards an economy that relies more on human creativity and knowledge than any other raw material, even oil"
Volunteering, Skills and Employment in Uganda - Refugee Youth Volunteering Uganda Working Paper 3
Creators: name: Tukundane, Cuthbert
name: Kanyandago, Peter
Publisher: name: Northumbria University
Year: 2024
Subjects: classificationCode: 440602
subject: Development geography
classificationCode: 440403
subject: Labour, migration and development
classificationCode: 390308
subject: Technical, further and workplace education

description: This Working Paper is part of the Refugee Youth Volunteering Uganda (RYVU) project, an interdisciplinary research project funded by the UK’s Global Challenges Research Fund (GCRF) and Economic and Social Research Council (ESRC).
This Working Paper 3 is co-authored by Dr Cuthbert Tukundane and Prof Peter Kanyandago and focuses on the challenges and questions relating to the link between volunteering, skills acquisition and access to employment by young refugees in Uganda.
Ability and utility of the Physician Well-Being Index to identify distress among Chinese physicians
Creators: name: Li, Zejun
name: Pu, Peng
name: Wu, Min
name: Wang, Xin
name: Xu, Huixue
name: Zhang, Xiaoyu
name: Deng, Qijian
name: Yang, Winson Fuzun
name: Liu, Yueheng
name: Wang, Qianjin
name: Li, Manyun
name: Hao, Yuzhu
name: He, Li
name: Wang, Yunfei
name: Wu, Qiuxia
name: Tang, Yi-Yuan
name: Liu, Tieqiao
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Despite the high prevalence of mental stress among physicians, reliable screening tools are scarce. This study aimed to evaluate the capability of the Physician Well-Being Index (PWBI) in identifying distress and adverse consequences among Chinese physicians. This cross-sectional online survey recruited 2803 physicians from Southern Mainland China via snowball sampling between October and December 2020. Data on socio-demographic characteristics, the PWBI, mental distress (including quality of life [QOL], burnout, sleepiness, fatigue and suicidal ideation) and adverse outcomes (medical errors and turnover intention) were collected. Chi-square tests and logistic regression were used for data analysis. Seven items of the PWBI (emotional exhaustion, depression, stress, poor mental and physical QOL, low work meaning and dissatisfaction with work-life integration) were independently associated with low QOL (all p < 0.05). Physicians with lower QOL were more likely to endorse each item (OR: 1.76-5.86) and less likely to have favourable index scores (all p < 0.001). Assuming a prevalence of 29.2% for low QOL, the PWBI could reduce the post-test probability to 6.9% or increase it to 70.8%. Physicians scoring ≥4 on the PWBI were at increased risk (likelihood ratio >1) for experiencing various mental distress, with sensitivity exceeding 80% in detecting burnout, depression, high stress and anxiety. Additionally, the PWBI score helped stratify physicians’ likelihood of reporting medical errors and turnover intention. This study provides preliminary insights into the validity and utility of the 9-item PWBI as a screening tool for assessing distress and well-being among Chinese physicians, helping identify those at higher risk of medical errors or turnover. However, these findings should be interpreted with caution due to the limited sample size. Physicians with lower quality of life were more likely to endorse these items on the PWBI. The PWBI was effective in stratifying physicians’ likelihood of experiencing mental distress. The PWBI effectively predicted the likelihood of physicians reporting recent medical errors and their turnover intention.
The prediction potential indexes the meaning and communicative function of upcoming utterances
Creators: name: Antoine, Salomé
name: Grisoni, Luigi
name: Tomasello, Rosario
name: Pulvermüller, Friedemann
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Prediction potential
subject: Pragmatic processing
subject: Semantic processing
subject: Language understanding
subject: EEG
subject: Event-related potential
subject: 400 Sprache::410 Linguistik::410 Linguistik

description: Prediction has a fundamental role in language processing. However, predictions can be made at different levels, and it is not always clear whether speech sounds, morphemes, words, meanings, or communicative functions are anticipated during dialogues. Previous studies reported specific brain signatures of communicative pragmatic function, in particular enhanced brain responses immediately after encountering an utterance used to request an object from a partner, but relatively smaller ones when the same utterance was used for naming the object. The present experiment now investigates whether similar neuropragmatic signatures emerge in recipients before the onset of upcoming utterances carrying different predictable communicative functions. Trials started with a context question and object pictures displayed on the screen, raising the participant's expectation that words from a specific semantic category (food or tool) would subsequently be used to either name or request one of the objects. Already 600 msec before utterance onset, a larger prediction potential was observed when a request was anticipated relative to naming expectation. As this result is congruent with the neurophysiological difference previously observed right after the critical utterance, the anticipatory brain activity may index predictions about the social-communicative function of upcoming utterances. In addition, we also found that the predictable semantic category of the upcoming word was likewise reflected in the anticipatory brain potential. Thus, the neurophysiological characteristics of the prediction potential can capture different types of upcoming linguistic information, including semantic and pragmatic aspects of an upcoming utterance and communicative action.
Human enhancers associated with immune response harbor specific sequence composition, activity, and genome organization
Creators: name: Charles-Henri Lecellier
name: Wyeth W. Wasserman
name: Mathelier, Anthony
Publisher: name: F1000Research
Year: 2016

description: Enhancers are distal DNA regions involved in the transcriptional regulation of gene expression. Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM consortium recently characterized > 38; 000 enhancers in the human genome. This mapping provides us with the unprecedented opportunity to examine potential specific DNA sequence features and functions. We used the distribution of guanine and cytosine nucleotides at enhancer regions to distinguish two classes of enhancers with distinct DNA shape patterns. A functional analysis of their protein-coding gene targets, predicted from CAGE signal correlation in 975 human samples, highlighted that one class of enhancers was significantly enriched for associations with immune response genes. Confirming this result, we found that this class of enhancers harbors regulatory motifs recognized by TFs involved in immune response (e.g. NF-κB). While these enhancers were generally repressed or lowly active, we observed that they were preferentially activated upon bacterial infection. Looking at chromatin capture data, we found that the two classes of enhancers were lying in distinct topologically-associated domains and chromatin loops. Together these results suggest that specific DNA sequence patterns can encode classes of enhancers that are functionally distinct and specifically organized in the human genome.
Upholding Haitian Dignity: On Briefly Contextualizing Haiti’s Ongoing Crisis, Part One
Creators: name: Faugas, Woodger
Publisher: name: figshare
Year: 2022
Subjects: subject: History
subject: 200211 Postcolonial Studies
subject: FOS: Other humanities
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: During the summer of 2021, Jovenel Moïse, Haiti’s 58th president, succumbed to an internationally-coordinated assassination attempt carried out by Columbian mercenaries, and others. The head of state sustained a broken femur, fractured skull, and gunshot wounds, among other signs of trauma. Furthermore, his wife of 25 years, Martine, clung to life nearby, gravely-injured and pretending to have expired. This piece, at first, highlights the effects of foreign intervention on Haitian history. It then pinpoints the compounded obstacles that Haitian leadership must surmount in placing Haiti on a path toward prosperity. Some of the points made pertain to the way(s) in which Haiti’s crisis began in the late 1400’s, when Spain’s Catholic Monarchs funded Columbus’s search for new trade routes to lands east of Europe. Conclusively, this work details how, in 1804, amidst a sea of hostility, Haiti proclaimed its independence as the world’s first Black-led republic, inspiring slave revolts throughout the world and majorly contributing toward U.S. expansion, through compelling France’s sale of the Louisiana Territory.
CMAPLE: Efficient Phylogenetic Inference in the Pandemic Era
Creators: name: Ly-Trong, Nhan
name: Bielow, Chris
name: De Maio, Nicola
name: Minh, Bui Quang
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: phylogenetics
subject: phylogenomics
subject: epidemiology
subject: maximum likelihood
subject: models of sequence evolution
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: We have recently introduced MAPLE (MAximum Parsimonious Likelihood Estimation), a new pandemic-scale phylogenetic inference method exclusively designed for genomic epidemiology. In response to the need for enhancing MAPLE's performance and scalability, here we present two key components: (i) CMAPLE software, a highly optimized C++ reimplementation of MAPLE with many new features and advancements, and (ii) CMAPLE library, a suite of application programming interfaces to facilitate the integration of the CMAPLE algorithm into existing phylogenetic inference packages. Notably, we have successfully integrated CMAPLE into the widely used IQ-TREE 2 software, enabling its rapid adoption in the scientific community. These advancements serve as a vital step toward better preparedness for future pandemics, offering researchers powerful tools for large-scale pathogen genomic analysis.
Auxin regulatory module evolution during C4 plant evolution
Creators: name: Chang, Yao-Ming
name: Shih, Arthur Chun-Chieh
name: Wen-Hsiung Li
Publisher: name: F1000Research
Year: 2016

description: Auxin, a plant phytohormone, plays an important role in vasculature development of vascular plants through the feedback regulation between auxin responsive factors (ARFs) and AUX/IAA proteins. In flowering plants, more than twenty genes in both ARF and AUX/IAA families have been identified but their regulatory relationships are still largely unknown. In this study, we analyzed three time-course transcriptome datasets from maize foliar (C4), husk (C3-like) and rice (C3) embryonic leaves and found that most ARF transcription factors are coexpressed with AUX/IAA genes in all three types of leaves but their co-expression patterns differ from each other, indicating that the auxin regulatory modules of leaf development have evolved during the evolution from C3 to C4 plants. In addition, we compared the promoter regions of each group of ARF homologs across seven C3 and C4 flowering plants and found that many of them have not been conserved across the species. That is, the ARF genes with different expression profiles among C3, C3-like and C4 leaves have been affected by changes in cis-regulation. Therefore, we propose that changes in ARF-AUX/IAA regulation have contributed to the evolution of vasculature structure from C3 to C4 leaves.
Smart Engineering Practices for Climate Action
Creators: name: Hossain, Md. Sazzad
Publisher: name: Zenodo
Year: 2025
Subjects: climate action
green technology
engineering

description: Smart Engineering Practices for Climate Action is a forward-looking technical paper that explores how modern engineering can drive climate solutions. Authored by Md. Sazzad Hossain, this article integrates practical engineering equations, real-world data, and cutting-edge practices—ranging from green design and energy efficiency to circular economy strategies and IoT-enabled automation. It emphasizes the role of life cycle assessment, smart grids, sustainable materials, and engineering education in creating a climate-resilient future. Ideal for professionals, students, and policymakers, the paper serves as both a knowledge base and a call to action for embedding sustainability at the core of engineering decision-making.
AmyloGram: a novel predictor of amyloidogenicity
Creators: name: Michał Burdukiewicz
name: Sobczyk, Piotr
name: Rödiger, Stefan
name: Paweł Mackiewicz
name: Małgorzata Kotulska
Publisher: name: F1000Research
Year: 2016

description: Amyloids are proteins associated with the number of clinical disorders (e.g., Alzheimer's, Creutzfeldt-Jakob’s and Huntington’s diseases). Despite their diversity, all amyloid proteins can undergo aggregation initiated by 6- to 15-residue segments called hot spots. Henceforth, amyloids form unique and often zipper-like β‑structures, which can turn out harmful. To find patterns defining the hot-spots, we trained predictors of amyloidogenicity based on random forests using n-grams extracted from amyloidogenic and non-amyloidogenic peptides collected in the AmyLoad database.

Since the amyloidogenicity may not depend on the exact sequence of amino acids but on more general properties of amino acids in the sequence, we constructed 524 284 reduced amino acid alphabets of different lengths (three to six letters) based on all possible combinations of the handpicked physicochemical properties of the amino acids. The cross-validation of predictors employing the different alphabets revealed the best-performing alphabet with the length of 6 amino acid residues. During analysis we found also 65 n-grams that are the most relevant to the discrimination of amyloid and non-amyloid sequences of which 15 were confirmed experimentally elsewhere.

The best-performing predictor, AmyloGram, was benchmarked against the most popular tools for amyloid peptides detection using an external dataset. It has obtained the highest values of performance measures (AUC: 0.90, MCC: 0.63).

AmyloGram is available as a web-server: smorfland.uni.wroc.pl/amylogram/ and was described in detail in PeerJ Preprint peerj.com/preprints/2390v1/ .
Distributed file systems for storage and analysis of Next-Generation Sequencing data
Creators: name: Beltrame, Luca
name: Travis, Anthony John
name: Clivio, Luca
name: Marchini, Sergio
name: D'Incalci, Maurizio
Publisher: name: F1000Research
Year: 2016

description: Analysis of NGS (Next Generation Sequencing) data is a computationally demanding task requiring large amounts of CPU, memory, and disk space. There is also a requirement for high performance data storage systems, resilient to hardware failure, to be connected directly to the computing infrastructure (typically a multi-node cluster) to store large quantities of NGS data reliably.

Traditional shared file systems such as NFS (Network File System) do not offer the performance, scalability or cache coherence required by modern NGS data analysis, so alternatives including GlusterFS, Ceph, and Lustre have been developed. However, there is a trade-off between data safety on replicated local storage and degradation of performance across distributed storage. Resilience to hardware failure is typically provided by RAID (Redundant Array of Independent Disks) and redundant storage nodes.

Here we describe the evaluation of an alternative file system, RozoFS (https://github.com/rozofs/rozofs) for use with demanding NGS data analysis workloads. We used a synthetic data set (DREAM-TCGA data set 3) to run a complete tumor-normal analysis pipeline (“bcbio”, https://github.com/chapmanb/bcbio-nextgen), including base quality recalibration, local indel realignment, somatic variant calling, and structural variants as a benchmark to compare RozoFS with a traditional shared file system (NFS) on two different HPC (High Performance Computing; Cloud4CaRE project) clusters.

Our results show high reliability and good performance of RozoFS compared to NFS, in particular, during heavy I/O workloads. These findings indicate that the reliability and robustness of RozoFS's make it a good candidate for demanding NGS analysis workloads.
The role of Phafin proteins in cell signaling pathways and diseases
Creators: name: Tang, Tuoxian
name: Sun, Jing
name: Li, Chen
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Phafin1
subject: Phafin2
subject: Pib2
subject: idiopathic pulmonary fibrosis
subject: cancer
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Membrane-associated proteins are important membrane readers that mediate and facilitate the signaling and trafficking pathways in eukaryotic membrane-bound compartments. The protein members in the Phafin family are membrane readers containing two phosphoinositide recognition domains: the Pleckstrin Homology domain and the FYVE (Fab1, YOTB, Vac1, and early endosome antigen 1) domain. Phafin proteins, categorized into two subfamilies, Phafin1 and Phafin2, associate with cellular membranes through interactions involving membrane-embedded phosphoinositides and phosphoinositide-binding domains. These membrane-associated Phafin proteins play pivotal roles by recruiting binding partners and forming complexes, which contribute significantly to apoptotic, autophagic, and macropinocytotic pathways. Elevated expression levels of Phafin1 and Phafin2 are observed in various cancers. A recent study highlights a significant increase in Phafin1 protein levels in the lungs of idiopathic pulmonary fibrosis patients compared to normal subjects, suggesting a crucial role for Phafin1 in the pathogenesis of pulmonary fibrosis. Additionally, phosphatidylinositol-3-phosphate-binding 2 (Pib2), a close relative of the Phafin1 protein, functions as an amino acid sensor activating the TOCR1 pathway in yeasts. This review focuses on delineating the involvement of Phafin proteins in cellular signaling and their implications in diseases and briefly discusses the latest research findings concerning Pib2.
Supplementary document for Experimental enhancement of six-beam quantum squeezing by phase-sensitive cascaded four-wave mixing processes - 7048593.pdf
Creators: name: Wang, Jiabin
name: Lou, Yanbo
name: Liu, Shengshuai
name: Jing, Jietai
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Theoretical details of six-beam quantum squeezing enhancement
Baccalaureate Service, 1944
Creators: name: State Teachers College
Publisher: name: Maryland Shared Open Access Repository
Year: 1944
Subjects: subject: State Teachers College
subject: Commencement ceremonies

description: Baccalaureate service program for August 24, 1944, which may include written corrections and annotations. While every effort is made to ensure accuracy in baccalaureate service programs, the service may have changed after the program was printed.
Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides
Creators: name: Maib, Hannes
name: Adarska, Petia
name: Hunton, Robert
name: Vines, James H.
name: Strutt, David
name: Bottanelli, Francesca
name: Murray, David H.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Biochemistry
subject: Membrane and lipid biology
subject: Technology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Phosphoinositides are a small family of phospholipids that act as signaling hubs and key regulators of cellular function. Detecting their subcellular distribution is crucial to gain insights into membrane organization and is commonly done by the overexpression of biosensors. However, this leads to cellular perturbations and is challenging in systems that cannot be transfected. Here, we present a toolkit for the reliable, fast, multiplex, and super-resolution detection of phosphoinositides in fixed cells and tissue, based on recombinant biosensors with self-labeling SNAP tags. These are highly specific and reliably visualize the subcellular distributions of phosphoinositides across scales, from 2D or 3D cell culture to Drosophila tissue. Further, these probes enable super-resolution approaches, and using STED microscopy, we reveal the nanoscale organization of PI(3)P on endosomes and PI(4)P on the Golgi. Finally, multiplex staining reveals an unexpected presence of PI(3,5)P2-positive membranes in swollen lysosomes following PIKfyve inhibition. This approach enables the versatile, high-resolution visualization of multiple phosphoinositide species in an unprecedented manner.
Baccalaureate Service, 1943
Creators: name: State Teachers College
Publisher: name: Maryland Shared Open Access Repository
Year: 1943
Subjects: subject: State Teachers College
subject: Commencement ceremonies

description: Baccalaureate service program for August 22, 1943, which may include written corrections and annotations. While every effort is made to ensure accuracy in baccalaureate service programs, the service may have changed after the program was printed.
Supplementary document for Experimental enhancement of six-beam quantum squeezing by phase-sensitive cascaded four-wave mixing processes - 7090778.pdf
Creators: name: Wang, Jiabin
name: Lou, Yanbo
name: Liu, Shengshuai
name: Jing, Jietai
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Theoretical details of six-beam quantum squeezing enhancement
title: Letter: C. Harrison Mann, Jr. to J. Lindsay Almond, Jr., August 16, 1957
Creators: name: Mann, Charles Harrison, Jr., 1908-1977
Publisher: name: George Mason University
Year: 2005
Subjects: subject: Almond, J. Lindsay, Jr.
subject: Politics
subject: Danville (VA)

description: Letter: typescript unsigned, 11.5" x 8.5" (29.21 cm x 21.59 cm)
description: Letter from C. Harrison Mann, Jr. asking J. Lindsay Almond, Jr. to be careful that statements to the press do not jeopardize Almond's pull with moderate and conservative voters. C. Harrison Mann, Jr. Collection 1.01
Fluoride recovery in degradable fluorinated polyesters
Creators: name: Fornacon-Wood, Christoph
name: Stühler, Merlin R.
name: Millanvois, Alexandre
name: Steiner, Luca
name: Weimann, Christiane
name: Silbernagl, Dorothee
name: Sturm, Heinz
name: Paulus, Beate
name: Plajer, Alex
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: fluoride recovery
subject: degradable fluorinated polymers
subject: new class
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: We report a new class of degradable fluorinated polymers through the copolymerization of tetrafluorophthalic anhydride and propylene oxide or trifluoropropylene oxide which show up to 20 times quicker degradation than the non-fluorinated equivalents and allow for fluoride recovery.
Platform lobbying: Policy influence strategies and the EU's Digital Services Act
Creators: name: Gorwa, Robert
name: Lechowski, Grzegorz
name: Schneiss, Daniel
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Platform power
subject: Lobbying
subject: Business power
subject: Policy influence
subject: Platform governance
subject: 300 Sozialwissenschaften::320 Politikwissenschaft::320 Politikwissenschaft

description: This paper examines how platform companies seek to lobby and otherwise influence policymakers during heated regulatory episodes. While there has been some valuable recent work on different policy influence strategies deployed by platform firms, in particular the emerging use of “user-facing” tactics of consumer mobilisation, current research tends to neglect the role of specific institutional contexts and related power structures intermediating the exertion of business power. Developing an institutionally situated approach, we offer an analysis of platform policy influence during the Digital Services Act (DSA) negotiations in the EU from 2019-2022. Through an analysis of political science literature on business power and interest group politics, we outline five strategies of corporate policy influence (access lobbying, coalition building, stakeholder mobilisation, public relations, and funding). Drawing on freedom of information requests, the EU Transparency register, and civil society watchdog reporting, we then provide an analysis of how platform firms sought to influence EU policymakers through these strategies around the DSA.
The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation - First Insights
Creators: name: Bender, Martin
name: Abicht, Jan-Michael
name: Reichart, Bruno
name: Leuschen, Maria
name: Wall, Felicia
name: Radan, Julia
name: Neumann, Elisabeth
name: Mokelke, Maren
name: Buttgereit, Ines
name: Michel, Sebastian
name: Ellgass, Reinhard
name: Gieseke, Katja
name: Steen, Stig
name: Paskevicius, Audrius
name: Denner, Joachim
name: Godehardt, Antonia W.
name: Tönjes, Ralf R.
name: Hagl, Christian
name: Ayares, David
name: Wolf, Eckhard
name: Schmoeckel, Michael
name: Brenner, Paolo
name: Müller, Martin B.
name: Längin, Matthias
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: heart
subject: xenotransplantation
subject: endothelial glycocalyx
subject: endothelial activation
subject: organ preservation
subject: orthotopic heart transplantation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::617 Chirurgie und verwandte medizinische Einrichtungen

description: Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are necessary. In allotransplantation, endothelial cells and their sugar-rich surface—the endothelial glycocalyx—are known to influence organ rejection. In xenotransplantation, however, only in vitro data exist on the role of the endothelial glycocalyx so far. Thus, in the current study, we analyzed the changes of the endothelial glycocalyx components hyaluronan, heparan sulfate and syndecan-1 after pig-to-baboon cardiac xenotransplantations in the perioperative (n = 4) and postoperative (n = 5) periods. These analyses provide first insights into changes of the endothelial glycocalyx after pig-to-baboon cardiac xenotransplantation and show that damage to the endothelial glycocalyx seems to be comparable or even less pronounced than in similar human settings when current strategies of cardiac xenotransplantation are applied. At the same time, data from the experiments where current strategies, like non-ischemic preservation, growth inhibition or porcine cytomegalovirus (a porcine roseolovirus (PCMV/PRV)) elimination could not be applied indicate that damage of the endothelial glycocalyx also plays an important role in cardiac xenotransplantation.
ЎЗБЕКИСТОН РЕСПУБЛИКАСИДА НОДАВЛАТ НОТИЖОРАТ ТАШКИЛОТЛАР ФАОЛИЯТИНИНГ РИВОЖЛАНИШИ
Creators: name: Абазов, Хабибулло
Publisher: name: Zenodo
Year: 2025

description: Ушбу мақола Ўзбекистон Республикасида нодавлат нотижорат ташкилотлар (ННТ) фаолиятининг ривожланиш босқичлари, уларнинг ҳуқуқий асослари, ижтимоий-иқтисодий аҳамияти ва фаолиятини қўллаб-қувватлаш механизмлари таҳлил қилинган. Шунингдек, ННТларнинг фуқаролик жамиятини ривожлантиришдаги роли, давлат ва жамият ўртасидаги ҳамкорлик, шунингдек, соҳадаги мавжуд муаммолар ва уларни ҳал этиш йўллари кўриб чиқилган.
Characterizing the Relationship Between Cortical Gradients and Cognitive Traits in Children
Creators: name: Zwally, Mia
name: Lam, Ka Chun
name: Thomas, Adam
name: Moraczewski, Dustin
Publisher: name: Zenodo
Year: 2024

description: Description

Poster presented by Mia Zwally at the 2024 Organization for Human Brain Mapping annual meeting. The poster was presented June 26-27, 2024.
Characterization of Atomic and Physical Properties of Biofield Energy Treated Manganese Sulfide Powder
Creators: name: Trivedi, Mahendra
Publisher: name: SMN - The ScienceMedia Network
Year: 2016
Subjects: Natural Sciences
Chemistry

description: Manganese sulfide (MnS) is known for its wide applications in solar cell, opto-electronic devices, and photochemical industries. The present study was designed to evaluate the effect of biofield energy treatment on the atomic and physical properties of MnS. The MnS powder sample was equally divided into two parts, referred as to be control and to be treated. The treated part was subjected to Mr. Trivedi’s biofield energy treatment. After that, both control and treated samples were investigated using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and electron spin resonance (ESR) spectroscopy. The XRD data revealed that the biofield energy treatment has altered the lattice parameter, unit cell volume, density, and molecular weight of the treated MnS sample as compared to the control. The crystallite size on various planes was significantly changed from -50.0% to 33.3% in treated sample as compared to the control. The FT-IR analysis exhibited that the absorption band attributed to Mn-S stretching vibration was reduced from (634 cm-1) to 613 cm-1 in treated MnS as compared to the control. Besides, the ESR study revealed that g-factor was reduced by 3.3% in the treated sample as compared to the control. Therefore, the biofield energy treated MnS could be applied for the use in solar cell and semiconductor applications.
Supplementary document for PUDCN: two-dimensional phase unwrapping with deformable convolutional network - 7049111.pdf
Creators: name: li, youxing
name: Meng, Lingzhi
name: Zhang, Kai
name: Zhang, Yin
name: xie, yaoqing
name: libo, yuan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: PUDCN: SUPPLEMENT 1
Supplementary document for PUDCN: two-dimensional phase unwrapping with deformable convolutional network - 7087141.pdf
Creators: name: li, youxing
name: Meng, Lingzhi
name: Zhang, Kai
name: Zhang, Yin
name: xie, yaoqing
name: libo, yuan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: PUDCN: SUPPLEMENT 1
title: Address to the Spectroscopy Society of Canada on 27 October, 1970
Creators: name: Herzberg, Gerhard
Publisher: name: Spectroscopy Society of Canada
Year: 1970
Subjects: subject: Herzberg, Gerhard
subject: Herzberg, Gerhard
subject: science policy
subject: politique scientifique

description: Speech delivered October 27, 1970 (typed version of speech)
description: Discours prononcé le 27 octobre 1970 (version dactylographiée du discours)
description: The Gerhard Herzberg fonds is held at the NRC Archives. Contact NRC.DR-DN.CNRC@nrc-cnrc.gc.ca for information about access.
description: Le fonds Gerhard Herzberg est conservé aux Archives du CNRC. Contactez NRC.DR-DN.CNRC@cnrc-nrc.gc.ca pour des informations sur l'accès.
Supplementary document for PUDCN: two-dimensional phase unwrapping with deformable convolutional network - 6994078.pdf
Creators: name: li, youxing
name: Meng, Lingzhi
name: Zhang, Kai
name: Zhang, Yin
name: xie, yaoqing
name: libo, yuan
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: PUDCN: SUPPLEMENTAL DOCUMENT 1
Supplementary document for Spatial-spectral mapping to prepare the frequency entangled qudits - 6360856.pdf
Creators: name: Yang, Zi-Xiang
name: Zeng, Zi-Qi
name: Tian, Ying
name: Wang, Shun
name: Shimizu, Ryosuke
name: Wu, Hao-Yu
name: Liu, Shilong
name: Jin, Rui-Bo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Document
Baccalaureate Service, 1946
Creators: name: State Teachers College
Publisher: name: Maryland Shared Open Access Repository
Year: 1946
Subjects: subject: State Teachers College
subject: Commencement ceremonies

description: Baccalaureate service program for August 22, 1946, which may include written corrections and annotations. While every effort is made to ensure accuracy in baccalaureate service programs, the service may have changed after the program was printed.
Baccalaureate Service, 1945
Creators: name: State Teachers College
Publisher: name: Maryland Shared Open Access Repository
Year: 1945
Subjects: subject: State Teachers College
subject: Commencement ceremonies

description: Baccalaureate service program for August 23, 1945, which may include written corrections and annotations. While every effort is made to ensure accuracy in baccalaureate service programs, the service may have changed after the program was printed.
The Journey of Self-Discovery: Exploring Photography as a Form of Personal Expression
Creators: name: Oliveira D., M. Jorge
Publisher: name: EmpowerVerse Media, Information & Communication Agency
Year: 2024
Subjects: photography
expression
creativity

description: Photography offers more than a way to capture moments; it’s a powerful tool for self-discovery and personal expression. By delving into the artistic and emotional dimensions of photography, we can embark on a journey of understanding ourselves better and conveying our inner world through visual storytelling. This article explores how photography becomes a medium for reflection, creativity, and connection, offering practical insights for enthusiasts at any stage in their journey.