cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Impact of target volume segmentation accuracy and variability on treatment planning for 4D-CT-based non-small cell lung cancer radiotherapy
Creators: name: Johnson, Carol
name: Palma, David A.
name: Louie, Alexander V.
name: Yu, Edward
name: Rodrigues, George B.
name: Martin, Spencer
name: Brophy, Mark
name: Barron, John L.
name: Beauchemin, Steven S.
name: Yaremko, Brian
name: Ahmad, Belal
name: Gaede, Stewart
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Medicine
subject: Engineering

description: Background. Accurate target volume segmentation is crucial for success in image-guided radiotherapy. However, variability in anatomical segmentation is one of the most significant contributors to uncertainty in radiotherapy treatment planning. This is especially true for lung cancer where target volumes are subject to varying magnitudes of respiratory motion.Material and methods. This study aims to analyze multiple observer target volume segmentations and subsequent intensity-modulated radiotherapy (IMRT) treatment plans defined by those segmentations against a reference standard for lung cancer patients imaged with four-dimensional computed tomography (4D-CT). Target volume segmentations of 10 patients were performed manually by six physicians, allowing for the calculation of ground truth estimate segmentations via the simultaneous truth and performance level estimation (STAPLE) algorithm. Segmentation variability was assessed in terms of distance- and volume-based metrics. Treatment plans defined by these segmentations were then subject to dosimetric evaluation consisting of both physical and radiobiological analysis of optimized 3D dose distributions.Results. Significant differences were noticed amongst observers in comparison to STAPLE segmentations and this variability directly extended into the treatment planning stages in the context of all dosimetric parameters used in this study. Mean primary tumor control probability (TCP) ranged from (22.6 ± 11.9)% to (33.7 ± 0.6)%, with standard deviation ranging from 0.5% to 11.9%. However, mean normal tissue complication probabilities (NTCP) based on treatment plans for each physician-derived target volume well as the NTCP derived from STAPLE-based treatment plans demonstrated no discernible trends and variability appeared to be patient-specific. This type of variability demonstrated the large-scale impact that target volume segmentation uncertainty can play in IMRT treatment planning.Conclusions. Significant target volume segmentation and dosimetric variability exists in IMRT treatment planning amongst experts in the presence of a reference standard for 4D-CT-based lung cancer radiotherapy. Future work is needed to mitigate this uncertainty and ensure highly accurate and effective radiotherapy for lung cancer patients.
Every Last Drop: Reflections on a Small Enrollment Program
Creators: name: Sturges, Keith M.
name: Carbajo, Cristina M.
Publisher: name: Zenodo
Year: 2024
Subjects: small enrollment programs
program funding
qualitative evaluation
confidentiality
small grants

description: Is it worth the effort for community colleges to pursue NSF ATE grant funds for small enrollment programs? This manuscript describes our experiences with a program that served 11 students and four local employers in a high-need field. This collaborative writing effort is presented as a grant program postmortem review to share our experiences and review pertinent literature so that others, particularly prospective community college grant recipients and evaluators of those grants, may learn from our experiences. We discussed ways we were able to leverage a small program to our advantage and the size-specific issues that we were unable to resolve.
Additional file 1 of Supporting medical students to support peers: a qualitative interview study
Creators: name: Graves, Jane
name: Flynn, Eleanor
name: Woodward-Kron, Robyn
name: Hu, Wendy C. Y.
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Interview questions.
Anerkennung auf FutureSkills.sh
Creators: name: Lorenz, Anja
Publisher: name: HRK
Year: 2024
Subjects: competences
digital certificates
digital education
digital records
FutureSkills
higher education
infrastructure
microcredential
recognition
Schleswig-Holstein

description: Im Praxisbeispiel werden Möglichkeiten gezeigt, wie die Online-Kurse auf FutureSkills.sh in formale Lernangeboten eingebunden werden.
From the research on socially-sustainable agriculture (49). Sustainable food systems
Creators: name: Kwasek, Mariola (Ed.)
name: Kowalczyk, Stanisław
name: Krzyżanowski, Julian Tadeusz
name: Kwasek, Mariola
name: Kwasek, Mariola (Ed.)
name: Kowalczyk, Stanisław
name: Krzyżanowski, Julian Tadeusz
name: Kwasek, Mariola
Publisher: name: Unknown
Year: 2018
Subjects: subject: Agricultural and Food Policy
subject: Environmental Economics and Policy
subject: consumption
subject: conventional food
subject: food
subject: food systems
subject: high-quality food
subject: precision agriculture
subject: regional food
subject: socially-sustainable agriculture
subject: sustainable food systems
subject: traditional food

description: The monograph presents the following issues: food quality systems with their components and typology, factors determining the evolution of consumption patterns and driving forces of existing changes, high-quality food (ecological, regional and traditional), as well as precision agriculture. The aim of the study is to evaluate the benefits for human health and the natural environment resulting from sustainable food systems. Chapters: Food systems. Conventional food versus high-quality food. Benefits for environment resulting from precision agriculture.
Additional file 2 of Supporting medical students to support peers: a qualitative interview study
Creators: name: Graves, Jane
name: Flynn, Eleanor
name: Woodward-Kron, Robyn
name: Hu, Wendy C. Y.
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 2. Curricular strategies suggested by participants to facilitate peer support.
Pasillo entre padre e hija hablando de la oración del Padre Nuestro: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Additional file 1 of Predicting RNA splicing from DNA sequence using Pangolin
Creators: name: Zeng, Tony
name: Li, Yang I
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 Supplementary Note 1: Binary versus continuous prediction output. Supplementary Note 2: Identifying a test set with minimal similarity to the training data. Supplementary Note 3: Training Pangolin using quantitative splicing data from multiple species improve prediction. Supplementary Note 4: Pangolin versus MTSplice on predicting tissue-type-specific splicing. Supplementary Note 5: Identifying motifs involved in tissue-specific splicing. Supplementary Note 6: Mutations away from G at the -1 position of the 5’ splice site cause strong decreases in 5’ splice site usage. Supplementary Note 7: Predicting causal variants that explain inter-species divergence in splice site usage. Figure S1: Precision and recall at different distances from a splice site. Figure S2: Pangolin scores correlate with changes in splicing efficiency. Figure S3: Prediction of epistatic effects on RNA splicing as a combination of single SNP effects. Figure S4: Prediction of tissue specific splice site usage using Pangolin. Figure S5: Motifs characterizing tissue-specific splice sites. Figure S6: False sign rates of predicted causal variants underlying inter-species divergence in splice site usage. Figure S7: Survival function plots of tested BRCA1 variants. Figure S8: Precision and recall for BRCA1 predictions and fraction LOF at different cutoffs. Figure S9: Predicted effects of variants in BRCA1. Figure S10: Precision and recall for pathogenic versus benign variant classification using Pangolin versus SpliceAI. Figure S11: Predicted effects of variants in CHEK2. Figure S12: Schematic for identifying single causal variants. Figure S13: Comparison of training on binary classification of splice sites versus continuous usage estimates. Figure S14: Comparison between Pangolin and SpliceAI for predicting inter-species variation in splice site usage. Table S3: Evaluations on subsets of test genes. Table S4: Comparison of AUPRC between models trained on multiple species and on human only.
Breast cancer specialists’ views on and use of risk prediction models in clinical practice: A mixed methods approach
Creators: name: Pieterse, Arwen H.
name: Stiggelbout, Anne M.
name: Engelhardt, Ellen G.
name: Duijn-Bakker, Nanny Van
name: Kroep, Judith R.
name: Haes, Hanneke C. J. M. De
name: Smets, Ellen M. A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Medicine

description: Purpose. Risk prediction models (RPM) in breast cancer quantify survival benefit from adjuvant systemic treatment. These models [e.g. Adjuvant! Online (AO)] are increasingly used during consultations, despite their not being designed for such use. As still little is known about oncologists’ views on and use of RPM to communicate prognosis to patients, we investigated if, why, and how they use RPM.Methods. We disseminated an online questionnaire that was based on the literature and individual and group interviews with oncologists.Results. Fifty-one oncologists (partially) completed the questionnaire. AO is the best known (95%) and most frequently used RPM (96%). It is used to help oncologists decide whether or not to recommend chemotherapy (> 85%), to inform (86%) and help patients decide about treatment (> 80%), or to persuade them to follow the proposed course of treatment (74%). Most oncologists (74%) believe that using AO helps patients understand their prognosis.Conclusion. RPM have found a place in daily practice, especially AO. Oncologists think that using AO helps patients understand their prognosis, yet studies suggest that this is not always the case. Our findings highlight the importance of exploring whether patients understand the information that RPM provide.
Pasillo entre padre e hija hablando de la oración del Padre Nuestro: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Celinda y D. Antonio Moreno: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Pasillo entre padre e hija hablando de la oración del Padre Nuestro: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
FGF2 as a potential prognostic biomarker for proneural glioma patients
Creators: name: Freyhult, Eva
name: Per-Henrik Edqvist
name: Pontén, Fredrik
name: Tchougounova, Elena
name: Smits, Anja
name: Tamador Elsir
name: Gullbo, Joachim
name: Lennartsson, Johan
name: Bergqvist, Michael
name: Ekman, Simon
name: Sooman, Linda
name: Archita Jaiswal
name: Navani, Sanjay
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biotechnology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Background. The survival of high-grade glioma patients is poor and the treatment of these patients can cause severe side effects. This fosters the necessity to identify prognostic biomarkers, in order to optimize treatment and diminish unnecessary suffering of patients. The aim of this study was to identify prognostic biomarkers for high-grade glioma patients.Methods. Eleven proteins were selected for analysis due to their suggested importance for survival of patients with other types of cancers and due to a high variation in protein levels between glioma patients (according to the Human Protein Atlas, www.proteinatlas.org). Protein expression patterns of these 11 proteins were analyzed by immunohistochemistry in tumor samples from 97 high-grade glioma patients. The prognostic values of the proteins were analyzed with univariate and multivariate Cox regression analyses for the high-grade glioma patients, including subgroup analyses of histological subtypes and immunohistochemically defined molecular subtypes.Results. The proteins with the most significant (univariate and multivariate p < 0.05) correlations were analyzed further with cross-validated Kaplan-Meier analyses for the possibility of predicting survival based on the protein expression pattern of the corresponding candidate. Random Forest classification with variable subset selection was used to analyze if a protein signature consisting of any combination of the 11 proteins could predict survival for the high-grade glioma patients and the subgroup with glioblastoma patients. The proteins which correlated most significantly (univariate and multivariate p < 0.05) to survival in the Cox regression analyses were Myc for all high-grade gliomas and FGF2, CA9 and CD44 for the subgroup of proneural gliomas, with FGF2 having a strong negative predictive value for survival. No prognostic signature of the proteins could be found.Conclusion. FGF2 is a potential prognostic biomarker for proneural glioma patients, and warrants further investigation.
Brain tumors in Sweden: Data from a population-based registry 1999–2012
Creators: name: Bergqvist, Michael
name: Henriksson, Roger
name: Asklund, Thomas
name: Malmström, Annika
name: Björ, Ove
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Cancer
subject: Biological Sciences
subject: Biotechnology
subject: Neuroscience
subject: Cell Biology
subject: Medicine

description: Background. The Swedish brain tumor registry has, since it was launched in 1999, provided significant amounts of data on histopathological diagnoses and on important aspects of surgical and medical management of these patients. The purpose is mainly quality control, but also as a resource for research.Methods. Three Swedish healthcare regions, constituting 40% of the Swedish population, have had an almost complete registration. The following parameters are registered: diagnosis according to SNOMED/WHO classification, symptoms, performance status, pre- and postoperative radiology, tumor size and localization, extent of surgery and occurrence of postoperative complications, postoperative treatment, such as radiotherapy and/or chemotherapy, other treatments, complications and toxicity, occurrence of reoperation/s, participation in clinical trials, multidisciplinary conferences and availability of a contact nurse.Results. Surgical radicality has been essentially constant, whereas the use of early (within 72 hours) postoperative CT and MRI has increased, especially for high-grade glioma, which is a reflection of quality of surgery. Survival of patients with high-grade glioma has increased, especially in the age group 60–69. Patients aged 18–39 years had a five-year survival of 40%. Waiting times for the pathological report has been slightly prolonged. Geographical differences do exist for some of the variables.Conclusion. Population-based registration is valuable for assessment of clinical management, which could have impact on patient care. As a result of short survival and/or the propensity to affect cognitive functions this patient group has considerable difficulties to make their voices heard in society. We therefore believe that a report like the present one can contribute to the spread of knowledge and increase the awareness for this patient group among caregivers and policy makers.
IN03170 Vessagiri Rock B Inscription 4
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03170
Epigraphia Zeylanica
Vessagiri

description: IN03170 Vessagiri Rock B Inscription 4 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 15. Four Rock-Inscriptions from Vessagiriya at Anurādhapura,’ Epigraphia Zeylanica 4, pp. 128–136.
Functioning in lymphedema from the patients’ perspective using the International Classification of Functioning, Disability and health (ICF) as a reference
Creators: name: Viehoff, Peter B.
name: Gielink, Petra D. C.
name: Damstra, Robert J.
name: Heerkens, Yvonne F.
name: Ravensberg, Dorine C. Van
name: Neumann, Martino H. A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Earth and Environmental Sciences
Medicine

description: Purpose. To identify and quantify meaningful concepts in lymphedema from the patients’ perspectives using the International Classification of Functioning, Disability and Health (ICF).Methods. Six focus group interviews in five different centers were organized, audiotaped, transcribed verbatim and analyzed.Results. A total of 2681 relevant ICF linkings were performed with the focus group data, resulting in 130 different second-level categories. Of these 130 second-level categories, 41 (31.5%) categories were categorized as Body Functions, 20 (15.5%) as Body Structures, 41 (31.5%) as Activities and Participation, and 28 (21.5%) as Environmental Factors. Overall, the most important issues according to the patients were the use of hosiery and bandages, support and relationships, and the shape of structures related to movement.Conclusion. Based on their experiences with lymphedema, patients reported activity limitations and participation restrictions combined with impaired body functioning. Anatomical changes (Body Structures) were also often mentioned as a problem in daily life. Environmental factors may act as a barrier or facilitator for patient functioning. The ICF provides a valuable reference to identify concepts in statements from lymphedema patients. The results of this research will be used in the development of ICF Core Sets for lymphedema.
Reviving Darjeeling Mandarin: Challenges and Strategies for Sustainable Citrus Cultivation
Creators: name: T. S. Ghimiray*, S. Gurung and S. Ali
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: Darjeeling Mandarin (Citrus reticulata Blanco) stands as a prized citrus variety cultivated in the hilly terrains of Darjeeling and Kalimpong, West Bengal, India. Renowned for its distinctive flavour, easily peelable skin, and balanced sugar-acid blend, this citrus gem has historically been a cornerstone of local agriculture, with roots tracing back to the 19th century. However, despite its esteemed heritage, the production of Darjeeling Mandarin has faced significant challenges in recent years. A decline in production has been observed due to various factors plaguing the orchards. Aging trees, coupled with a shortage of quality planting materials, have hindered productivity. Pests and diseases have also posed threats, exacerbated by inadequate irrigation facilities and nutritional deficiencies in the soil. Climate change impacts, including erratic weather patterns, further complicate cultivation efforts.

Efforts to rejuvenate Darjeeling Mandarin cultivation are being met with both resilience and innovation. Availability of quality planting materials and optimizing irrigation systems are crucial steps towards sustainable production. Moreover, educational initiatives and government support aim to equip growers with the knowledge and resources needed to overcome these challenges. While the journey to revive Darjeeling Mandarin cultivation presents formidable challenges, the dedication of farmers and advancements in agricultural practices offer promising avenues for success. By addressing these obstacles head-on and embracing innovative solutions, the revival of Darjeeling Mandarin stands as a testament to the resilience of agricultural communities and the enduring appeal of this prized citrus variety.
D. Pedro Azedo y el Príncipe de Argel: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
D. Pedro Azedo y el Príncipe de Argel: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
D. Pedro Azedo y el Príncipe de Argel: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Estimating the reliability of aquifer transmissivity values obtained from specific capacity tests: examples from the Saguenay-Lac-Saint-Jean aquifers, Canada
Creators: name: Richard, Sandra K.
name: Chesnaux, Romain
name: Rouleau, Alain
name: Coupe, Richard H.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In the absence of well-documented pumping tests, we investigate whether a reliable estimate of transmissivity T can be obtained using historical records of specific capacity data in granular and fractured-rock aquifers. Transmissivity values are calculated from the specific capacity data Q/s in several hundred wells located in the Saguenay-Lac-Saint-Jean region (Canada), with an iterative method applied to the Cooper-Jacob equation. The results are compared with short- and long-duration pumping tests performed throughout the region. We demonstrate that values of transmissivity compare well between the different types of tests for each lithology, when the scale of the test is similar. Therefore, using historical information easily increases the number of transmissivity values that can be estimated over a region. These values can be integrated in regional numerical models. Moreover, this study shows that T = 4.48(Q/s)1.15 with R2 = 0.66 for granular aquifers. This new empirical relationship can be used in similar environments. Editor D. Koutsoyiannis Associate editor C. Leduc Editor D. Koutsoyiannis Associate editor C. Leduc
Veränderung des weichmagnetischen Verhaltens von Fe-Si Elektroblech unter mechanisch-zyklischer Langzeitbeanspruchung
Creators: name: Zuber, Rafael
Publisher: name: Karlsruhe
Year: 2020
Subjects: Werkstoffwissenschaften
Magnetwerkstoffe
Weichmagnete
Single-Sheet Tester
Versetzungen

description: In den letzten Jahren hat die Entwicklung von Elektrofahrzeugen stark zugenommen. Bei zukünftigen Antriebskonzepten spielen Elektromotoren eine entscheidende Rolle, da von Ihnen die Effizienz des Antriebs abhängt. Der aktuelle Trend geht zu immer kleiner werdenden Elektromotoren mit höheren Drehgeschwindigkeiten, in welchen das Material besonders in den Fokus rückt. Bei den einge-setzten Elektroblechen treten durch stetige Drehzahlwechsel hohe Flieh- und Magnetkräfte auf die zu lokalen Spannungen führen und damit die lokalen magnetischen Eigenschaften beeinträchtigen. In dieser Arbeit werden die magnetischen Eigenschaften von taillier-ten Fe-Si Blechstreifen nach zyklischer Beanspruchung für Ober-spannungen unterhalb der Streckgrenze untersucht. Die magnetische Charakterisierung erfolgt nach einem genormten Messverfahren mit einem speziell für die Messung von taillierten Blechstreifen konzipier-ten Single Sheet Tester. Bei der Charakterisierung werden die stati-schen Kommutierungskurven sowie die statischen und dynamischen Hysteresen gemessen. Mittels Verlustseparation werden die Einflüs-se mechanischer Zyklierung für die Hysterese-, Wirbelstrom- und Anomalieverluste bewertet. Zusätzlich zur spannungskontrollierten mechanischen Zyklierung wird der Einfluss einer dehnungskontrol-lierten Zyklierung bewertet. Als weiteres wird auch der Einfluss verschiedener Spannungs-verhältnisse und der Temperatureinfluss bei der mechanischen Zyklierung auf die magnetischen Eigenschaf-ten untersucht. Aus den gewonnenen Kennwerten wird eine Korrelati-on zwischen der Mechanik, der Magnetik und der Mikrostruktur abgeleitet. Unter Verwendung der Rasterelektronenmikroskopie und der Transmissionselektronenmikroskopie wird hierfür das Gefüge und die Versetzungsstruktur untersucht.
Digitale Bildung für alle Bürger*innen: Können Hochschulen das?
Creators: name: Lorenz, Anja
name: Röwert, Ronny
name: Schicke, Christiane
name: Wittke, Andreas
Publisher: name: Zenodo
Year: 2024

description: MOOCs, Science Slams, Podcasts … Hochschulen bemühen sich immer wieder, Angebote für die breite Bevölkerung zu machen, und scheitern immer wieder an ihrem eigenen Anspruch, stärker in die Gesellschaft hinein zu wirken. Es genügt nicht, lediglich die Pforten des Elfenbeinturms zu öffnen; auch die akademischen Formate selbst müssen angepasst werden. Und warum sollten sich Nicht-Studierende überhaupt für Angebote der Hochschulen interessieren, wenn sie keinen akademischen Abschluss anstreben?

Mit dem Digital Learning Campus (DLC) starten alle staatlichen Hochschulen des Landes Schleswig-Holstein einen neuen Versuch, diese Kluft zu überwinden, und die Entwicklung von Zukunftskompetenzen (Future Skills) aller Bürger*innen zu unterstützen. Dazu werden lokale Partner*innen und physische Lernorte eingebunden, um die Bevölkerung vor Ort zu erreichen.

Wir werden die “Pain Points” ansprechen, warum Hochschulversuche zur Erreichung der breiten Bevölkerung scheitern könnten, und zeigen, wie wir es in Projekten wie dem DLC trotzdem schaffen können.
Electronic Supplementary Material from Genome-wide association mapping within a local Arabidopsis thaliana population more fully reveals the genetic architecture for defensive metabolite diversity
Creators: name: Gloss, Andrew D.
name: Vergnol, Amélie
name: Morton, Timothy C.
name: Laurin, Peter J.
name: Roux, Fabrice
name: Bergelson, Joy
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Plant Biology
subject: 60408 Genomics

description: Supplementary Note, Methods, Tables, and Figures
Escelencias de la santisima cruz: Digital edition
Creators: name: Betti Miguel
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Estimating the reliability of aquifer transmissivity values obtained from specific capacity tests: examples from the Saguenay-Lac-Saint-Jean aquifers, Canada
Creators: name: Richard, Sandra K.
name: Chesnaux, Romain
name: Rouleau, Alain
name: Coupe, Richard H.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: In the absence of well-documented pumping tests, we investigate whether a reliable estimate of transmissivity T can be obtained using historical records of specific capacity data in granular and fractured-rock aquifers. Transmissivity values are calculated from the specific capacity data Q/s in several hundred wells located in the Saguenay-Lac-Saint-Jean region (Canada), with an iterative method applied to the Cooper-Jacob equation. The results are compared with short- and long-duration pumping tests performed throughout the region. We demonstrate that values of transmissivity compare well between the different types of tests for each lithology, when the scale of the test is similar. Therefore, using historical information easily increases the number of transmissivity values that can be estimated over a region. These values can be integrated in regional numerical models. Moreover, this study shows that T = 4.48(Q/s)1.15 with R2 = 0.66 for granular aquifers. This new empirical relationship can be used in similar environments. Editor D. Koutsoyiannis Associate editor C. Leduc Editor D. Koutsoyiannis Associate editor C. Leduc
FDG-PET/CT during concomitant chemo radiotherapy for esophageal cancer: Reducing target volumes to deliver higher radiotherapy doses
Creators: name: Michel, Pierre
name: Vera, Pierre
name: Lamyaa Nkhali
name: Thureau, Sébastien
name: Edet-Sanson, Agathe
name: Doyeux, Kaya
name: Benyoucef, Ahmed
name: Gardin, Isabelle
name: Dubray, Bernard
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Physics
subject: Biophysics

description: Background. A planning study investigated whether reduced target volumes defined on FDG-PET/CT during radiotherapy allow total dose escalation without compromising normal tissue tolerance in patients with esophageal cancer.Material and methods. Ten patients with esophageal squamous cell carcinoma (SCC), candidate to curative-intent concomitant chemo-radiotherapy (CRT), had FDG-PET/CT performed in treatment position, before and during (Day 21) radiotherapy (RT). Four planning scenarios were investigated: 1) 50 Gy total dose with target volumes defined on pre-RT FDG-PET/CT; 2) 50 Gy with boost target volume defined on FDG-PET/CT during RT; 3) 66 Gy with target volumes from pre-RT FDG-PET/CT; and 4) 66 Gy with boost target volume from during-RT FDG-PET/CT.Results. The median metabolic target volume decreased from 12.9 cm3 (minimum 3.7–maximum 44.8) to 5.0 cm3 (1.7–13.5) (p = 0.01) between pre- and during-RCT FDG-PET/CT. The median PTV66 was smaller on during-RT than on baseline FDG-PET/CT [108 cm3 (62.5–194) vs. 156 cm3 (68.8–251), p = 0.02]. When total dose was set to 50 Gy, planning on during-RT FDG-PET/CT was associated with a marginal reduction in normal tissues irradiation. When total dose was increased to 66 Gy, planning on during-RT PET yielded significantly lower doses to the spinal cord [Dmax = 44.1Gy (40.8–44.9) vs. 44.7Gy (41.5–45.0), p = 0.007] and reduced lung exposure [V20Gy = 23.2% (17.3–27) vs. 26.8% (19.7–30.2), p = 0.006].Conclusion. This planning study suggests that adaptive RT based on target volume reduction assessed on FDG-PET/CT during treatment could facilitate dose escalation up to 66 Gy in patients with esophageal SCC.
Establishing implantation uncertainties for focal brachytherapy with I-125 seeds for the treatment of localized prostate cancer
Creators: name: Uulke A. Van Der Heide
name: Polders, Daniel L.
name: Steggerda, Marcel
name: Herk, Marcel Van
name: Kiri Nichol
name: Witteveen, Thelma
name: Moonen, Luc
name: Nijkamp, Jasper
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Cancer
subject: Biological Sciences
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology

description: Background. The efficacy of focal continuous low dose-rate brachytherapy (CLDR-BT) for prostate cancer requires that appropriate margins are applied to ensure robust target coverage. In this study we propose a method to establish such margins by emulating a focal treatment in patients treated with CLDR-BT to the entire gland.Material and methods. In 15 patients with localized prostate cancer, prostate volumes and dominant intra-prostatic lesions were delineated on pre-treatment magnetic resonance imaging (MRI). Delineations and MRI were registered to trans-rectal ultrasound images in the operating theater. The patients received CLDR-BT treatment to the total prostate volume. The implantation consisted of two parts: an experimental focal plan covering the dominant intra-prostatic lesion (F-GTV), followed by a plan containing additional seeds to achieve entire prostate coverage. Isodose surfaces were reconstructed using follow-up computed tomography (CT). The focal dose was emulated by reconstructing seeds from the focal plan only. The distance to agreement between planned and delivered isodose surfaces and F-GTV coverage was determined to calculate the margin required for robust treatment.Results. If patients had been treated only focally, the target volume would have been reduced from an average of 40.9 cm3 for the entire prostate to 5.8 cm3 for the focal plan. The D90 for the F-GTV in the focal plan was 195 ± 60 Gy, the V100 was 94% [range 71–100%]. The maximum distance (cd95) between the planned and delivered isodose contours was 0.48 cm.Conclusions. This study provides an estimate of 0.5 cm for the margin required for robust coverage of a focal target volume prior to actually implementing a focal treatment protocol.
Effects of cushioning pads on heel and forefoot plantar pressurereduction in walking and running
Creators: name: Satta Srewaradachpisal
name: Charoenyutr Dechwayukul
name: Surapong Chatpun
name: Wiriya Thongruang
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: cushion insole
mechanical properties
plantar pressure
walking
running

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1685-1693
Mechanical properties of repair welds for aluminum alloy6082-T6 by pulsed MIG welding process
Creators: name: Thet Htet Naing
name: Prapas Muangjunburee
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: pulsed MIG welding
aluminum alloy 6082-T6
repair welds
porosity
mechanical properties

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1694-1700
Determination of water content of a residual soil slope in response toinfiltrating rainwater using transient seepage model and its verification
Creators: name: Thitinan Indhanu
name: Panupong Thumtuan
name: Tanan Chub-Uppakarn
name: Tanit Chalermyanont
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: transient seepage model
residual soil slope
volumetric water content
pore water pressure

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1701-1707
Biomechanical evaluation of lag screw fixationin oblique humeral shaft fracture: A finite element study
Creators: name: Phachara Suklim
name: Chaiwat Chuaychoosakoon
name: Atichart Kwanyuang
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: long oblique fracture
lag screw and plate fixation
biomechanics
finite element analysis
interfragmentary compression

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1708-1715
Determination of rare earth elements, uranium and thoriumin soil samples by microwave-assisted acid digestionand inductively coupled plasma mass spectrometry
Creators: name: Sasikarn Nuchdang
name: Ratchai Fungklin
name: Wilasinee Kingkam
name: Dussadee Rattanaphra
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: rare earth elements
microwave-assisted acid digestion
inductively coupled plasma mass spectrometry
soil sample

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1716-1725
Establishing an automated graphical genome analysis platform
Creators: name: Wison Laochareonsuk
name: Komwit Surachat
name: Surasak Sangkhathat
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: cancer research
medical bioinformatics
online analysis platform

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1726-1735
VMAT technique enables concomitant radiotherapy of prostate cancer and pelvic bone metastases
Creators: name: Kairemo, Kalevi
name: Vaalavirta, Leila
name: Kiljunen, Timo
name: Kangasmäki, Aki
name: Aaltonen, Aili
name: Partanen, Kaarina
name: Greetta Joensuu
name: Alanko, Tuomo
name: Joensuu, Timo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Physiology
subject: Cell Biology
subject: Medicine
subject: Physics

description: Background. Prostate cancer (PCa) patients with metastatic disease often suffer from skeletal pain and urinary retention impairing their quality of life. Prophylactic radiotherapy to bone metastases planned concomitantly with primary PCa radiotherapy could enable more precise control of combined dose in healthy tissues when compared to sequential palliative treatment.Materials and methods. Volumetric modulated arc therapy (VMAT) was planned for 14 PCa patients with primary bone metastases. The bone planning target volume (PTVbone) was contoured together with the PTVs of prostate (pr), pelvic lymph nodes (ln) and seminal vesicles (sv). Another virtual plan was calculated excluding PTVbone for dose volume histogram (DVH) comparison. DVHs were additionally compared to a set of actual VMAT treatment plans of a control cohort of 13 high risk PCa patients treated with PTVpr, PTVsv and PTVln. The prescribed doses varied between 42 and 76 Gy for PTVbone.Results. Recommended healthy tissue tolerances (Quantec) were not exceeded except for one patient's rectum V50Gy value. Rectum doses did not increase significantly due to the inclusion of PTVbone. For bladder, there was a slight increase for V65Gy and V50Gy (2.7% and 7.4%). The DVHs of metastatic and non-metastatic patients were comparable. There were no differences in the PTVpr DVH parameters, while mean PTVln dose increased by 3.7 Gy–4.4 Gy due to the increased treatment volume related to PTVbone. All side effects were < grade 3 during the mean follow-up duration of 25 months.Conclusions. VMAT offers a good optimization tool for adding extra PTVs to the radiotherapy plan. Radiotherapy of bone metastases concomitantly with irradiation of the primary prostate tumor is a safe and well-tolerated approach and deserves to be studied in a randomized setting.
Genetic study of SPINK1 and PRSS1 in idiopathic chronic pancreatitisand allele frequencies of SPINK1 and PRSS1in the southern Thai population
Creators: name: Putthimet Lekhakul Promin
name: Wison Laochareonsuk
name: Netinatsunton, Nisa
name: Supika Kritsaneepaiboon
name: Surasak Sangkhathat
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: idiopathic chronic pancreatitis
single nucleotide polymorphisms
SPINK1
PRSS1

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1736-1742
Reliability of sentinel node procedure for lymph node staging in prostate cancer patients at high risk for lymph node involvement
Creators: name: Joniau, Steven
name: Haustermans, Karin
name: Deroose, Christophe M.
name: Isebaert, Sofie
name: Oyen, Raymond
name: Mottaghy, Felix M.
name: Poppel, Hendrik Van
name: Lerut, Evelyne
name: Bergh, Laura Van Den
name: Ameye, Filip
name: Berkers, Joost
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Cell Biology
subject: Medicine

description: Aim. To investigate the reliability of a sentinel node (SN) procedure for nodal staging in prostate cancer (PCa) patients at high risk for lymph node (LN) involvement.Material and methods. Seventy-four patients with localized prostate adenocarcinoma, who were clinically node-negative and had a risk of LN involvement of ≥ 10% (Partin tables), were prospectively enrolled. Upon intraprostatic 99mTc-nanocolloid injection, they underwent planar scintigraphy and SPECT imaging. Surgical removal of the SN, located by means of a gamma probe, was completed with a superextended LN dissection (seLND) as a reference and followed by radical prostatectomy.Results. In total, 470 SN (median 6, IQR 3–9) were scintigraphically detected of which 371 (median 4, IQR 2–6) were located by gamma probe and selectively removed during surgery (79%). Histopathology confirmed LN metastases in 37 patients (50%) having 106 affected LN in total (median number per patient 2, IQR 1–4). Twenty-eight patients were node positive (N+) based on the analysis of the resected SN. However, the seLND that was performed as a reference revealed nine additional N+ patients resulting in a sensitivity of 76% (28/37). In total, 15 of 37 patients (41%) had metastases in SN only and could have been spared seLND to remove all affected nodes.Conclusion. We found a relatively low sensitivity when addressing the SN procedure for nodal staging in PCa patients at high risk for LN involvement. Importantly, only less than half of the N+ patients could have been spared a seLND to remove all affected lymphoid tissue.
Escelencias de la santisima cruz: Digital edition
Creators: name: Miguel, Betti
name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Structural and morphological characterization ofThai monazite ore processing samples
Creators: name: Sasikarn Nuchdang
name: Wilasinee Kingkam
name: Vichai Puripunyavanich
name: Unchalee Suwanmanee
name: Pipat Laowattanabandit
name: Dussadee Rattanaphra
Publisher: name: Research and Development Office, Prince of Songkla University
Year: 2021
Subjects: monazite ore processing
structural
morphological
characterization
rare earth element

description: Songklanakarin Journal of Science an Technology (SJST), 43, 6, 1743-1750