cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantum Cryptography Based on Orthogonal States
Creators: name: Goldenberg, Lior
name: Vaidman, Lev
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: All existing quantum cryptosystems use non-orthogonal states as the carriers of information. Non-orthogonal states cannot be cloned (duplicated) by an eavesdropper. In result, any eavesdropping attempt must introduce errors in the transmission, and therefore, can be detected by the legal users of the communication channel. Orthogonal states are not used in quantum cryptography, since they can be faithfully cloned without altering the transmitted data. In this Letter we present a cryptographic scheme based on orthogonal states, which also assures the detection of any eavesdropper.
description: Latex, 10 pages, 1 figure (decompress with "uudecode" and "unzip"). Submitted to Physical Review Letters.
Echinus esculentus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Echinoidea
Camarodonta
Echinidae
Echinus
Echinus esculentus

description: Echinus esculentus [spec. nov.]
E. hemisphaerico-globosus; ambulacris denis; areis obsolete verrucosis.
Faun. svec. 1289. Echinus subglobosus, vertice plano.
List. angl. 169. t. 3. f. 13. Echinus marinus aculeorum vestigiis nonnihil eminentibus.
Rumph. mus. 31. t. 13. f. B. Echinus esculentus.
Klein. echinod. 16. t. 9. Cidaris miliaris.
Habitat in Oceano Europaeo & Indico.
Testa punctis callosis obsoletis; apertura subrotunda, nec 10 fissuris. Spinae violaceae apice albae.
Ideam sculpturae Echinorum distincte formaturus, comparationem ejusdem instituat cum Horto in Areas sive Pulvillos diviso, Ambulacris distincto.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 663, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Evolution of the solar wind speed with heliocentric distance and solar cycle. Surprises from Ulysses and unexpectedness from observations of the solar corona
Creators: name: Khabarova, O. V.
name: Obridko, V. N.
name: Kislov, R. A.
name: Malova, H. V.
name: Bemporad, A.
name: Zelenyi, L. M.
name: Kuznetsov, V. D.
name: Kharshiladze, A. F.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: An extensive analysis of Ulysses observations of the solar wind speed V from 1990 to 2008 is undertaken. It is shown that the evolution of V with heliocentric distance r depends substantially on both the heliolatitude and the solar activity cycle. Deviations from the predicted Parker's profile of V(r) are so considerable that cannot be explained by a scarcity of measurements or other technical effects. In particular, the expected smooth growth of the solar wind speed with r is typical only for the solar activity maximum and for low heliolatitudes (lower than +/-40deg), while at high latitudes, there are two V(r) branches: growing and falling. In the solar activity maximum, V increases toward the solar pole in the North hemisphere only; however, in the South hemisphere, it decreases with heliolatitude. In the minimum of solar activity, the profile of V(r) at low heliolatitudes has a local minimum between 2 and 5 AU. This result is confirmed by the corresponding data from other spacecraft (Voyager 1 and Pioneer 10). Unexpected spatial variations in V at low heliolatitudes can be explained by the impact of coronal hole flows on the V(r) profile since the flows incline to the ecliptic plane. To reproduce the impact of spatial variations of V in the polar corona on the behavior of V at low heliolatitudes, a stationary one-fluid ideal MHD-model is developed with account of recent results on imagery of the solar wind speed in the corona up to 5.5 solar radii obtained on the basis of combined observations from SOHO/UVCS, LASCO, and Mauna Loa.
description: 14 pages, 9 figures, 1 table
Save yourself! FAIR-ify your digital research in 45 minutes!
Creators: name: Camphuijsen, Jaro
name: Ferguson, Kim
Publisher: name: Zenodo
Year: 2024
Subjects: FAIR
research data management

description: Workshop delivered at NWO Life 2024 conference, Egmond aan Zee, May 23, 2024. 

Abstract:

You probably produce (new or derived) data in your research, and in the process, you most likely use and/or produce some kind of software (code or program). When it comes to research data and software there are oh so many ways to get stuck, mess something up or get lost entirely in your or someone else's creations. In the race to publish our papers, we often overlook important aspects that make the data or software more sustainable and reusable. In this workshop, the Netherlands eScience Center and DANS join forces to show you that it is not so complicated and always for your benefit to make your research data and software FAIR (Findable, Accessible, Interoperable and Reusable) and to give you some practical tools and tips to get going. You will notice that improving your workflow with these simple steps will help you stay more relaxed and save yourself a lot of work and time while doing even better science and getting the credit for it!

 

See related works for the two breakout presentations mentioned within the presentation.

 

Note:

The slide deck is distributed the same across two file formats: .pptx and .pdf. The .pptx format is the most (web) accessible, while the .pdf serves as a stable visual version with accessible features. In case of format issues, the .pdf file would be considered the reference file - this reference file is denoted by "1-" at the beginning of the file name.
Additional file 1 of Consolidation chemotherapy after definitive concurrent chemoradiotherapy in patients with inoperable esophageal squamous cell carcinoma: a multicenter non-inferiority phase III randomized clinical trial
Creators: name: Fan, Chengcheng
name: Wang, Xu
name: Zheng, Xiaoli
name: Sun, Yanan
name: Ye, Ke
name: Jiang, Yue
name: Liu, Xiao
name: Xu, Wencai
name: Liu, Yang
name: Yang, Yuanyuan
name: Liu, Jinsong
name: Jiang, Qiong
name: He, Chunyu
name: Wu, Xiaoyuan
name: Nie, Xin
name: Zhang, Jingwei
name: Tan, Bo
name: Wang, Wen
name: Zhang, Yougai
name: Feng, Zhuo
name: Yang, Chengliang
name: Lu, Yufei
name: Liu, Hailong
name: Chen, Xijuan
name: Xu, Jing
name: Liu, Fang
name: Zheng, Xuefeng
name: Wang, Jianhua
name: Wu, Shang
name: Chen, Guofu
name: Zhang, Yaowen
name: Jin, Linzhi
name: Ge, Hong
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Supplementary Material 1.
Minimal geometric deformation decoupling in $2+1$ dimensional space-times
Creators: name: Contreras, Ernesto
name: Bargueño, Pedro
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the minimal geometric deformation decoupling in $2+1$ dimensional space--times and implement it as a tool for obtaining anisotropic solutions from isotropic geometries. Interestingly, both the isotropic and the anisotropic sector fulfill Einstein field equations in contrast to the cases studied in $3+1$ dimensions. In particular, new anisotropic solutions are obtained from the well known static BTZ solution.
description: Figure and some comments added. Accepted in EPJC
Additional file 5: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Creators: name: Taraneh Ebrahimi
name: Rust, Marcus
name: Kaiser, Sarah
name: Slowik, Alexander
name: Beyer, Cordian
name: Koczulla, Andreas
name: Schulz, Jörg
name: Pardes Habib
name: Bach, Jan
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Figure S5. (A) Since there are no oligodendrocytes contaminating the cell culture, NLRP3-expression was not oligodendrocyte-induced. (B) NLRP3-expression was indeed induced by the few present microglia. But the majority of NLRP3-expression was not microglia-mediated. n = 3. (PDF 385 kb)
Additional file 6: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Creators: name: Taraneh Ebrahimi
name: Rust, Marcus
name: Kaiser, Sarah
name: Slowik, Alexander
name: Beyer, Cordian
name: Koczulla, Andreas
name: Schulz, Jörg
name: Pardes Habib
name: Bach, Jan
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Figure S6. (A) 10 μM Aβ1–42 significantly increased caspase 1 mRNA. Co-treatment with A1AT blocked the increase of caspase 1 mRNA expression significantly. (B) Stimulation with Aβ1–42 significantly increased IL-1β mRNA. Gene expression of IL-1β was significantly reduced with A1AT-co-treatment. (C) In contrast, Aβ1–42-stimulation such as A1AT-treatment did not affect IL-18 mRNA expression. Data of n = 6 in triplicate represent mean ± SD. */ap
Laser cooling of CaF molecules
Creators: name: Zhelyazkova, Valentina
Publisher: name: Imperial College London
Year: 2014

description: Cold and ultracold molecules are highly desirable for a diverse range of applications in physics and chemistry such as precision measurements, tests of fundamental physics, quantum simulation and information processing, quantum chemistry, and the physics of strongly correlated quantum matter. Laser cooling is usually infeasible in molecules because their rotational and vibrational transitions make is difficult to come up with a closed scattering cycle. Recently, a narrow range of diatomic molecules, one of which is CaF, has been shown to possess a convenient electronic structure and a highly-diagonal Franck-Condon matrix and thus be amenable to laser cooling. This thesis describes experiments on laser cooling of CaF radicals produced in a supersonic source. We first investigate the increased fluorescence when multi-frequency resonant light excites the molecules from the four hyperfine levels of the ground X²∑+(N = 1, v = 0) state to the first excited A²π½ (J’ = 1=2; v’ = 0) state. The number of photons scattered per molecule increases significantly from one or two in the single frequency case to more than 50 before the molecules get pumped into the X²∑+(N = 1; v = 1) state. We demonstrate laser cooling and slowing of CaF using counter-propagating laser light which causes the molecules to scatter more than a thousand photons on the X (N = 1, v = 0, 1) A (J’ = 1=2; v’ = 0) transition. The effect of the laser cooling is to slow a group of molecules from 600 ms-1 to about 580 ms-1 and to narrow their velocity distribution from an initial temperature of 3 K down to 300 mK. In addition, chirping the frequency of the cooling light to keep it on resonance with the decelerating molecules doubles the deceleration and further compresses the velocity distribution. The effect of the laser cooling is limited by the optical pumping of molecules in the X (N = 1, v = 2) state.
Adding Salt to Pepper: A Structured Security Assessment over a Humanoid Robot
Creators: name: Giaretta, Alberto
name: De Donno, Michele
name: Dragoni, Nicola
Publisher: name: arXiv
Year: 2018
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: The rise of connectivity, digitalization, robotics, and artificial intelligence (AI) is rapidly changing our society and shaping its future development. During this technological and societal revolution, security has been persistently neglected, yet a hacked robot can act as an insider threat in organizations, industries, public spaces, and private homes. In this paper, we perform a structured security assessment of Pepper, a commercial humanoid robot. Our analysis, composed by an automated and a manual part, points out a relevant number of security flaws that can be used to take over and command the robot. Furthermore, we suggest how these issues could be fixed, thus, avoided in the future. The very final aim of this work is to push the rise of the security level of IoT products before they are sold on the public market.
description: 8 pages, 3 figures, 4 tables
Additional file 1 of Bidirectional association of neurodevelopment with growth: a prospective cohort study
Creators: name: Wei, Xiaotong
name: Hu, Jiajin
name: Yang, Liu
name: Gao, Ming
name: Li, Lin
name: Ding, Ning
name: Ma, Yanan
name: Wen, Deliang
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Additional file 1: Supplemental Table 1. Demographic characteristics of mother-child pairs, comparing those with and without infant BMI data
Robust feedback model predictive control of norm-bounded uncertain systems
Creators: name: Tahir, Furqan
Publisher: name: Imperial College London
Year: 2014

description: This thesis is concerned with the Robust Model Predictive Control (RMPC) of linear discrete-time systems subject to norm-bounded model-uncertainty, additive disturbances and hard constraints on the input and state. The aim is to design tractable, feedback RMPC algorithms that are based on linear matrix inequality (LMI) optimizations. The notion of feedback is very important in the RMPC control parameterization since it enables effective disturbance/uncertainty rejection and robust constraint satisfaction. However, treating the state-feedback gain as an optimization variable leads to non-convexity and nonlinearity in the RMPC scheme for norm-bounded uncertain systems. To address this problem, we propose three distinct state-feedback RMPC algorithms which are all based on (convex) LMI optimizations. In the first scheme, the aforementioned non-convexity is avoided by adopting a sequential approach based on the principles of Dynamic Programming. In particular, the feedback RMPC controller minimizes an upper-bound on the cost-to-go at each prediction step and incorporates the state/input constraints in a non-conservative manner. In the second RMPC algorithm, new results, based on slack variables, are proposed which help to obtain convexity at the expense of only minor conservatism. In the third and final approach, convexity is achieved by re-parameterizing, online, the norm-bounded uncertainty as a polytopic (additive) disturbance. All three RMPC schemes drive the uncertain-system state to a terminal invariant set which helps to establish Lyapunov stability and recursive feasibility. Low-complexity robust control invariant (LC-RCI) sets, when used as target sets, yield computational advantages for the associated RMPC schemes. A convex algorithm for the simultaneous computation of LC-RCI sets and the corresponding controller for norm-bounded uncertain systems is also presented. In this regard, two novel results to separate bilinear terms without conservatism are proposed. The results being general in nature also have application in other control areas. The computed LC-RCI sets are shown to have substantially improved volume as compared to other schemes in the literature. Finally, an output-feedback RMPC algorithm is also derived for norm-bounded uncertain systems. The proposed formulation uses a moving window of the past input/output data to generate (tight) bounds on the current state. These bounds are then used to compute an output-feedback RMPC control law using LMI optimizations. An output-feedback LC-RCI set is also designed, and serves as the terminal set in the algorithm.
INTRODUKTSIYA QILINGAN GALOFIT O'SIMLIKLARNING AYRIM MORFOFIZIOLOGIK XUSUSIYATLARI
Creators: name: Jumanov, O'.
name: Kuliev, T.
name: Qo'shiev, H.
name: Xaqberdieva, H.
Publisher: name: Zenodo
Year: 2024

description: Chetdan introduktsiya qilingan Atriplex undulata, A. nummularia A. amnicola va Acacia ampliceps o‘simlik turlarining har xil darajada sho‘rlangan tuproq sharoitida o’sishi va rivojlanish bosqichlaridagi morfofiziologik xususiyatlari o‘rganildi. Har xil darajada sho‘rlangan tuproq sharoitida o‘simliklarning poyasining uzunligi hamda yer usti biomassasining quruq va xo‘l xoldagi ko‘rsatkichlari asosida farq aniqlandi. Bunda Atriplex undulata, A. nummularia A. amnicola kuchsiz va o‘rta sho‘rlanish darajasiga ega bo‘lgan tuproq sharoitida poya uzunligi kuchli farq qilmadi, lekin yer ustki biomassasi sho‘rlanmagan tuproq sharoitda yuqori ekanligi qayd qilindi. Kuchli sho‘rlangan tuproq sharoitda esa o‘simliklar urug‘ining unuvchanlik hamda poya uzunligi va yer usti biomassaslarida ham farq, ya’ni past ko‘rsatkichlar kuzatildi. Huddi shuga o‘xshash xolat Acacia ampliceps o‘simligida ham kuzatilgan bo‘lsada, lekin kuchsiz sho‘rlangan va sho‘rlanmagan tuproq sharoitda ham o‘simlik bo‘yicha, yer usti biomassasida sezilarli farqlar kuzatildi.
On Compton Scattering Scenarios for Blazar Flares
Creators: name: Boettcher, M.
name: Dermer, C. D.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The synchrotron reflection scenario recently proposed to explain $γ$-ray flares observed from blazar jets is studied. Our analysis takes into account the angular distribution of the beamed radiation, the finite extent of the scattering region, and light travel-time effects. We compare energy densities and powers for synchrotron, SSC, reflected synchrotron (RSy), and external Compton (EC) scattering processes. If the width of the scattering layer is much larger than $ΓR^\prime_B$, where $Γ$ and $ R^\prime_B$ denote the bulk Lorentz factor and comoving-frame radius of the plasma blob, respectively, then the ratio of the RSy and synchrotron energy densities $\sim 4 Γ^3 n_{BLR} σ_{T} R^\prime_B$, where $n_{BLR}$ is the mean particle density in the broad line region (BLR). Our results imply that Thomson-thick scattering regions of narrow extent must be present for the synchrotron reflection mechanism to operate effectively. This process seems unlikely to cause flares in lineless BL Lac sources, where X-ray and TeV flares are common and the BLR is thought to be weak or absent. We sketch time profiles of flares for various scenarios, including a model where the blob is energized by sweeping up surrounding material.
description: 12 pages, including 2 figures; uses epsf.sty, rotate.sty. Submitted to ApJ Letters
First results from the 2dF galaxy redshift survey
Creators: name: Colless, Matthew
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The 2dF Galaxy Redshift Survey is a major new initiative to map a representative volume of the universe. The survey makes use of the 2dF multi-fibre spectrograph at the Anglo-Australian Telescope to measure redshifts for over 250,000 galaxies brighter than B=19.5 and a further 10,000 galaxies brighter than R=21. The main goals of the survey are to characterise the large-scale structure of the universe and quantify the properties of the galaxy population at low redshifts. This paper describes the design of the survey and presents some preliminary results from the first 8000 galaxy redshifts to be measured.
description: To appear in Phil.Trans.R.Soc.Lond.A, 12 pages, 8 figures, LaTeX and rspublic.sty
Additional file 1 of Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof
Creators: name: Aboras, Sara I.
name: Megahed, Ahmed A.
name: El-Yazbi, Fawzy
name: Maher, Hadir M.
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Additional file 1: Figure S1. First derivative spectra of different concentrations of FVM (5, 10, 20 μg/mL) and IVM (2.5, 10, 15 μg/mL). Figure S2. Second derivative spectra of different concentrations of FVM (5, 10, 20 μg/mL) and IVM (2.5, 10, 15 μg/mL). Figure S3. Derivative ratio spectra (I) of different concentrations of FVM (5, 10, 20 μg/mL) using 10 μg/mL IVM as divisor. Figure S4. Derivative ratio spectra (II) of different concentrations of IVM (5, 10, 20 μg/mL) using 10 μg/mL FVM as divisor. Table S1. Summary of assay results and one–way analysis of variance (ANOVA) for the determination of FVM and IVM by FFAS, FFDS, FFRS, and DWZ.
Chiton Linnaeus, 1758, gen. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Polyplacophora
Chitonida
Chitonidae
Chiton

description: Chiton [gen. nov.]
Animal Doris.
Testae plures, longitudinaliter digestae, dorso incumbentes.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 667, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Bacteriophage: from bacteria to targeted gene delivery to mammalian cells
Creators: name: Yata, Teerapong
Publisher: name: Imperial College London
Year: 2014

description: Bacteriophage (phage), bacterial viruses, have been improved as non-human pathogenic viral vectors for the purpose of introducing genetic materials into mammalian cells. Previously, our group generated a novel Adeno-associated virus/Phage (AAVP) hybrid vector as a valuable tool for targeted gene transfer to mammalian cells. However, the efficacy of bacteriophage-based vectors is considered relatively poor, meaning that ways of improving it are of considerable interest. First approach to improve AAVP-mediated gene delivery is through chemical modification. We showed that the transduction efficiency of AAVP was increased by the complexation of phage vectors with cationic molecules and calcium phosphate co-precipitation. Application of the bacteriophage complex carrying a cytotoxic gene resulted in eradication of cultured brain tumour cells. The chemically modified vector showed superior gene delivery over the conventional vector and can thus be regarded as an improved version of phage-based vector that has promise in cancer gene therapy. Next, we demonstrated that Extracellular Matrix (ECM) presents an obstacle for AAVP. Using brain cancer cell lines as a model, AAVP transduction was significantly increased by collagenase and hyaluronidase-mediated degradation of ECM, which can subsequently be translated into tumour cell eradication through AAVP-mediated gene therapy. Our findings prove that combination of AAVP vectors with ECM depletion represents a powerful strategy to advance phage- guided gene transfer. Finally, we engineered the prototype bacteriophage-based multifunctional vector as a proof-of-concept model that can simultaneously display three different peptides and carry a mammalian transgene cassette. Our results show that bacteriophage can be used as a scaffold for constructing multifunctional carriers that integrate multiple functions, which may have great potential for gene delivery applications. Together, the data demonstrate the potential for improved AAVP-based gene transfer to mammalian cells focusing on the use of chemical modification, manipulation of ECM, and the generation of multifunctional phage vectors.
Quasi-stable configurations of torus vortex knots and links
Creators: name: Ruban, Victor P.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Pattern Formation and Solitons (nlin.PS)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The dynamics of torus vortex configurations $V_{n,p,q}$ in a superfluid liquid at zero temperature ($n$ is the number of quantum vortices, $p$ is the number of turns of each filament around the symmetry axis of the torus, and $q$ is the number of turns of the filament around its central circle; radii $R_0$ and $r_0$ of the torus at the initial instant are much larger than vortex core width $ξ$) has been simulated numerically based on a regularized Biot-Savart law. The lifetime of vortex systems till the instant of their substantial deformation has been calculated with a small step in parameter $B_0=r_0/R_0$ for various values of parameter $Λ=\log(R_0/ξ)$. It turns out that for certain values of $n$, $p$, and $q$, there exist quasi-stability regions in the plane of parameters $(B_0,Λ)$, in which the vortices remain almost invariable during dozens and even hundreds of characteristic times.
description: 6 pages, 19 figures, English translation of Russian original, to appear as JETP 127(3), 581-586 (2018)
An investigation of recent and novel genetic variants that are associated with the pathogenesis of amyotrophic lateral sclerosis and their implications on phenotypes of the disease
Creators: name: Kwok, Chun T
Publisher: name: Imperial College London
Year: 2014

description: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by loss of motor neurons in the spinal cord, brain stem and cerebral cortex. ALS is characterized by both upper and lower motor neuron symptoms and death usually occurs 3-5 years after onset. Familial histories are found in 5-10% of ALS cases while the rest are sporadic. This study is focused on analysing known and novel candidate genes in ALS and the aims of study are to characterize causal genes and risk factors for Familial ALS (FALS) and Sporadic ALS (SALS) in the Imperial Cohorts, in which genetic causes have been assigned for 64% of FALS cases. Three strategies were pursued and genes involved in proteostasis pathways were emphasized in this study. Firstly, we sequenced known candidate genes in our FALS cases excluded for known mutations. VCP and SQSTM1 genes were sequenced. We did not identify any coding changes in VCP but report a 5’ hexanucleotide expansion exclusively found in ALS. Known and novel SQSTM1 mutations, P392L and E155K, were identified in FALS kindred presenting with a history of Paget’s disease of bone. Secondly, we carried out association studies for two candidate genes on Chromosome 17, P4HB and NPLOC4, and showed that they were risk factors for FALS and SALS respectively. The association of P4HB SNPs with FALS survival time indicates that it is a modifier gene. Thirdly, to explore novel genes in ALS, we investigated Variable number tandem repeats (VNTR) from top candidate genes selected based on association signals from previous Genome wide association (GWA) studies and protein functions. VNTRs in NIPA1 and HSPB8 gene were associated with FALS and SALS respectively. Finally, we characterized the size of the reported hexanucleotide GGGGCC expansion in the C9orf72 gene using Southern blot analysis in our FALS cohort and interim results are presented.
Additional file 4: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Creators: name: Taraneh Ebrahimi
name: Rust, Marcus
name: Kaiser, Sarah
name: Slowik, Alexander
name: Beyer, Cordian
name: Koczulla, Andreas
name: Schulz, Jörg
name: Pardes Habib
name: Bach, Jan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Figure S4. No significant differences in cell metabolism were detected after increasing concentrations of Aβ1–42 (A), A1AT (B) or co-treatment of A1AT, Aβ1–42 and LPS (C). Data of n = 6 in triplicate represent mean ± SD, ns not significant compared to control. (PDF 260 kb)
Decay Rates of Metastable States in Cubic Potential by Variational Perturbation Theory
Creators: name: Kleinert, H.
name: Mustapic, I.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Variational perturbation theory is used to determine the decay rates of metastable states across a cubic barrier of arbitrary height. For high barriers, a variational resummation procedure is applied to the complex energy eigenvalues obtained from a WKB expansion; for low barriers, the variational resummation procedure converts the non-Borel-summable Rayleigh-Schrö\-din\-ger expansion into an exponentially fast convergent one. The results in the two regimes match and yield very accurate imaginary parts of the energy eigenvalues. This is demonstrated by comparison with the complex eigenvalues from solutions of the Schrödinger equation via the complex-coordinate rotation method.
Additional file 2 of Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice
Creators: name: Zhuang, Pan
name: Li, Haoyu
name: Jia, Wei
name: Shou, Qiyang
name: Zhu, Ya’er
name: Mao, Lei
name: Wang, Wenqiao
name: Wu, Fei
name: Chen, Xiaoqian
name: Wan, Xuzhi
name: Wu, Yuqi
name: Liu, Xiaohui
name: Li, Yin
name: Zhu, Fanghuan
name: He, Lilin
name: Chen, Jingnan
name: Zhang, Yu
name: Jiao, Jingjing
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Cancer

description: Additional file 1: Supplementary Tables and Figures
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0899
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0899, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0899, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Multi-sensor fusion for human-robot interaction in crowded environments
Creators: name: McKeague, Stephen John
Publisher: name: Imperial College London
Year: 2014

description: For challenges associated with the ageing population, robot assistants are becoming a promising solution. Human-Robot Interaction (HRI) allows a robot to understand the intention of humans in an environment and react accordingly. This thesis proposes HRI techniques to facilitate the transition of robots from lab-based research to real-world environments. The HRI aspects addressed in this thesis are illustrated in the following scenario: an elderly person, engaged in conversation with friends, wishes to attract a robot's attention. This composite task consists of many problems. The robot must detect and track the subject in a crowded environment. To engage with the user, it must track their hand movement. Knowledge of the subject's gaze would ensure that the robot doesn't react to the wrong person. Understanding the subject's group participation would enable the robot to respect existing human-human interaction. Many existing solutions to these problems are too constrained for natural HRI in crowded environments. Some require initial calibration or static backgrounds. Others deal poorly with occlusions, illumination changes, or real-time operation requirements. This work proposes algorithms that fuse multiple sensors to remove these restrictions and increase the accuracy over the state-of-the-art. The main contributions of this thesis are: A hand and body detection method, with a probabilistic algorithm for their real-time association when multiple users and hands are detected in crowded environments; An RGB-D sensor-fusion hand tracker, which increases position and velocity accuracy by combining a depth-image based hand detector with Monte-Carlo updates using colour images; A sensor-fusion gaze estimation system, combining IR and depth cameras on a mobile robot to give better accuracy than traditional visual methods, without the constraints of traditional IR techniques; A group detection method, based on sociological concepts of static and dynamic interactions, which incorporates real-time gaze estimates to enhance detection accuracy.
Development of an Ytterbium fibre based chirped pulse amplification laser system for high harmonic generation
Creators: name: Driever, Steffen
Publisher: name: Imperial College London
Year: 2015

description: In this thesis, I describe the development of a high repetition rate femtosecond fibre based chirped pulse amplification system (FCPA) for strong-field physics experiments. This project was set in a newly established sub-group of the Laser Consortium at Imperial College London with the aim to push the strong-field and attosecond science experiments to be conducted at 100s of kHz repetition rate. It was important to design and implement a compact, CEP stable, high repetition rate fibre CPA system. Custom optics and mounts were employed in order to achieve a compact stretcher and compressor design. The stretcher was designed to stretch the oscillator pulses with a bandwidth of 14nm and a duration of 90 fs to 1 ns to avoid non-linearities in the fibre amplifier. It is based on an Offner type configuration. The fast rise time RTP based Pockels cell can be adjusted to deliver 50 -350 kHz of repetition rate to the large mode area (LMA) ytterbium doped fibre with 30 um core and 250 um cladding (Yb1200-30/250DC-PM, Nlight). It was possible to generate up to 13 uJ of pulse energy at 100 kHz repetition rate before compression with 14W pump power. Higher pulse energies up to 130 uJ have been demonstrated at 38W of pumping (55W pump diode Nlight), however mechanical instabilities impaired the spectral and spatial performance at this power level. Improvements to optimise the performance of the system are suggested in the conclusion. Additionally to this experiments in the near-IR have been conducted on post compression mechanisms. The principle of filamentation was employed to generate tunable few-cycle pulses at wavelengths from 1.6 - 2 um and subsequent high harmonic generation in a proof of principle experiment. These results were published in Applied Physics Letters [1] and Journal of Physics B: At. Mol. Opt. Phys. [2].
Convolution algebras and the deformation theory of infinity-morphisms
Creators: name: Robert-Nicoud, Daniel
name: Wierstra, Felix
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Algebra (math.QA)
subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: Primary 18D50, Secondary 08C05, 18G55

description: Given a coalgebra C over a cooperad, and an algebra A over an operad, it is often possible to define a natural homotopy Lie algebra structure on hom(C,A), the space of linear maps between them, called the convolution algebra of C and A. In the present article, we use convolution algebras to define the deformation complex for infinity-morphisms of algebras over operads and coalgebras over cooperads. We also complete the study of the compatibility between convolution algebras and infinity-morphisms of algebras and coalgebras. We prove that the convolution algebra bifunctor can be extended to a bifunctor that accepts infinity-morphisms in both slots and which is well defined up to homotopy, and we generalize and take a new point of view on some other already known results. This paper concludes a series of works by the two authors dealing with the investigation of convolution algebras.
description: 17 pages, 1 figure; (v2): Expanded some proofs, corrected typos, updated references. Final version
Responsive, functional materials from self-stabilising and reactive branched addition co-polymers
Creators: name: Harbron, Rachel
Publisher: name: Imperial College London
Year: 2014

description: A one-component emulsion templating strategy for the preparation of inorganic-organic encapsulated droplets and hollow capsules has been developed. The process exploits, and relies on, both branched addition co-polymer architectures and compositions, which provide simultaneous properties of emulsion droplet steric-stabilisation and cross-linking function. It was demonstrated that high yielding encapsulation of different hydrophobic actives was successful whilst retaining the structural integrity of the capsule compartments. Responsive capsule surfaces and shell/membrane properties with pre-determined complex functionalities were demonstrated. The incorporation of chemical functionality within the reactive branched addition co-polymer allowed higher order responsive structures to be formed. These materials have been shown to be highly useful in the preparation of large associated aggregates which can be loaded with numerous payloads. The encapsulation of both hydrophobic dyes and an oil-soluble polymer was illustrated. Protocell constructs with pH-mediated, electrostatically gated permeability were prepared by covalently grafting a multi-responsive functional terpolymer to the outer surface of a cross-linked membrane of silica nanoparticle-based colloidosomes. Terpolymer grafted membrane functionality-mediated uptake and release of small molecules from the colloidosomes was demonstrated.
Additional file 1 of Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study
Creators: name: Fortunato, Francesca
name: Campanozzi, Angelo
name: Maffei, Gianfranco
name: Arena, Fabio
name: Carri, Valeria Delli
name: Rollo, Tiziana
name: Lopalco, Pier Luigi
name: Martinelli, Domenico
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 1
Uncertainty quantification in nuclear criticality modelling using methods of polynomial chaos
Creators: name: Ayres, Daniel
Publisher: name: Imperial College London
Year: 2015

description: In this thesis we use polynomial chaos expansions to represent the response of criticality calculations when they are subject to large numbers (many hundreds) of correlated nuclear data uncertainties. An adaptive high dimensional model representation (HDMR) is used to decompose the response parameter keff into a superposition of lower dimensional subspaces which are in-turn projected on to a polynomial basis. These projections are evaluated using an adaptive quadrature scheme which is used to infer the polynomial orders of the basis. The combination of adaptive HDMR and adaptive quadrature techniques results in a sparse polynomial expansion which has been optimised to represent the variance of the response with the minimum number of polynomials. The combined application of these techniques is illustrated using UOX and MOX pin cell problems with evaluated nuclear covariance data. We show that this approach to calculating the variance in keff is an order of magnitude more efficient when compared to Latin hypercube sampling with the same number of samples for problems involving up to 988 random dimensions. In the final chapter of this thesis, the adaptive HDMR and quadrature methods combined with polynomial chaos are applied to an industrially relevant problem; the computation of keff uncertainties due to evaluated covariance data. Uncertainties and first order sensitivities are computed from the polynomial chaos expansion which are compared to the results from the first order sensitivity method implemented in the Monte Carlo code MONK. We found that the local sensitivities and uncertainties derived from the PCE compare well with the MONK sensitivity method. These uncertainty quantification approaches were applied to fast spectrum uranium, plutonium and americium-241 critical assemblies. Comparisons between the uranium/plutonium and americium-241 uncertainties were made in the context of the 0.95 sub-critical limit. Suggestions for new sub-critical limits based on differing numbers of standard deviations below the mean values were proposed.
A Lightweight Universe?
Creators: name: Bahcall, Neta A.
name: Fan, Xiaohui
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: How much matter is there in the universe? Does the universe have the critical density needed to stop its expansion, or is the universe underweight and destined to expand forever? We show that several independent measures, especially those utilizing the largest bound systems known - clusters of galaxies - all indicate that the mass-density of the universe is insufficient to halt the expansion. A promising new method, the evolution of the number density of clusters with time, provides the most powerful indication so far that the universe has a sub-critical density. We show that different techniques reveal a consistent picture of a lightweight universe with only ~20-30% of the critical density. Thus, the universe may expand forever.
description: 11 pages, 3 PS figures, to appear in National Academy of Sciences Proc
Modelling of turbulent flames with transported probability density function and rate-controlled constrained equilibrium methods
Creators: name: Elbahloul, Salem A
Publisher: name: Imperial College London
Year: 2013

description: In this study, turbulent diffusion flames have been modelled using the Transported Probability Density Function (PDF) method and chemistry reduction with the Rate-Controlled Constrained Equilibrium (RCCE). RCCE is a systematic method of chemistry reduction which is employed to simulate the evolution of the chemical composition with a reduced number of species. It is based on the principle of chemical time-scale separation and is formulated in a generalised and systematic manner that allows a reduced mechanism to be derived given a set of constraint species. The transported scalar PDF method was coupled with RANS turbulence modelling and this PDF-RANS methodology was exploited to simulate several turbulent diffusion flames with detailed and RCCE-reduced chemistry. The phenomena of extinction and reignition, soot formation and thermal radiation in these flames are explored. Sandia Flames D, E and F have been simulated with both the detailed GRI-3.0 mechanism and RCCE reduced mechanisms. Scatter plots show that PDF methods with simple mixing models are able to reproduce different degrees of local extinction in Sandia piloted flames. The PDF-RCCE results are compared with PDF simulations with the detailed mechanism and with measurements of Sandia flames. The RCCE method predicted the three flames with the same level of accuracy of the detailed mechanism. The methodology has also been applied to sooting flames with radiative heat transfer. Semi-empirical soot model and Optically-thin radiation model have been combined with the PDF-RCCE method to compute these flames. Methane flames measured by Brooks and Moss [26] have been predicted using several RCCE mechanisms with good agreement with measurements. The propane flame with preheated air [162] has also been simulated with the PDF-RCCE methodology. Gaseous species profiles of the propane flame compare reasonably with measurements but soot and temperature predictions in this flame were weak and improvements are still needed.
Additional file 3: of α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes
Creators: name: Taraneh Ebrahimi
name: Rust, Marcus
name: Kaiser, Sarah
name: Slowik, Alexander
name: Beyer, Cordian
name: Koczulla, Andreas
name: Schulz, Jörg
name: Pardes Habib
name: Bach, Jan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Figure S3. (A) Stimulation with Aβ1–42 led to a concentration-dependent LDH-release. For further experiments, Aβ1–42 (10 μM) was selected as the maximum concentration to not exceed 50% of cell death. (B) Ascending concentrations of A1AT did not affect cell viability. (C) Co-treatment with Aβ1–42 and A1AT did not affect LDH-release, whereas LPS significantly increased LDH-release. Treatment with A1AT significantly reduced LDH-release in LPS-stimulated astrocytes. Data of n = 6 in triplicate represent mean ± SD. */ap