cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Clear cell ovarian carcinoma and emergence of the novel tumour suppressor gene ARID1A
Creators: name: Wiegand, Kimberly Charlotte
Publisher: name: University of British Columbia
Year: 2014

description: Clear cell carcinomas (CCCs) are a subtype of ovarian cancer that is understudied, and which does not respond well to conventional therapeutic strategies. There is a desperate need to clarify the genetic mechanisms of CCC to allow for the development of subtype specific therapeutics. To determine genetic changes responsible for the development of CCC, whole transcriptomes of 18 ovarian CCCs and one ovarian CCC cell line were sequenced. Somatic mutations were found in ARID1A in 6 samples. ARID1A encodes BAF250a, a key component of the SWI/SNF chromatin remodeling complex. ARID1A was sequenced in an additional 210 ovarian carcinomas and a second CCC cell line, and BAF250a expression was measured by immunohistochemistry (IHC) in an additional 455 ovarian carcinomas and over 3000 nonovarian malignancies. Overall, ARID1A mutations were seen in 46% of CCCs and 30% of endometrioid carcinomas (EC) implicating ARID1A as a tumour suppressor frequently disrupted in CCC and EC. Loss of the BAF250a protein correlated strongly with the presence of ARID1A mutations. In two patients, ARID1A mutations and loss of BAF250a expression were evident in the tumour and contiguous atypical endometriosis, implicating ARID1A loss as an early event in tumourigenesis. Screening 3000 cases of different malignancies by IHC showed loss of BAF250a was is most frequent in cancers of endometrial origin. Reverse phase protein array (RPPA) for tumour samples with known ARID1A mutation status revealed a notable change pAKT-Thr³⁰⁸ (FDR < 1%), which may allow for targeted therapeutic strategies in ARID1A deficient tumours. To identify compounds synthetic-lethal with ARID1A deficiency, two nearly isogenic cell lines were screened along with 18 other cell lines, including ten CCC cell lines of known ARID1A status against a panel of kinase inhibitors, revealing several promising therapeutic compounds effective at inhibiting the growth of CCC cell lines, including GSK461364, Pelitinib, and Tovok, however these did not appear to be dependent on ARID1A deficiency. Collectively, these studies provided the first report of ARID1A as a major tumour suppressor in cancers of endometrial origin and several other tumour types; these studies have now been validated by multiple groups in diverse tumour types.
Expression and Purification of Neurotoxin-Associated Protein HA-33/A from Clostridium botulinum and Evaluation of Its Antigenicity
Creators: name: Sayadmanesh, Ali
name: Ebrahimi, Firouz
name: Hajizade, Abbas
name: Mosayeb Rostamian
name: Keshavarz, Hani
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
title: Dopamine is involved in B cell function in female rheumatoid arthritis patients
Creators: name: Capellino, Silvia
name: Wieber, Karolin
name: Fleige, Leonie
name: Tsiami, Styliani
name: Reinders, Jörg
name: Braun, Jürgen
name: Baraliakos, Xenofon
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and consequently joint destruction. However, RA is not simply a disease of the joints but a systemic inflammation. Within the immune cells involved, B cells play critical roles in RA pathogenesis, and their depletion[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Components of the dilepton continuum in Pb+Pb collisions at $\sqrt{s_{_{NN}}} = 2.76 $ TeV
Creators: name: Kumar, V.
name: Shukla, P.
name: Vogt, R.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The dilepton invariant mass spectrum measured in heavy-ion collisions includes contributions from important QGP probes such as thermal radiation and the quarkonium ($J/ψ$, $ψ'$ and $Υ$) states. Dileptons coming from hard $q \bar q$ scattering, the Drell-Yan process, contribute in all mass regions. In heavy-ion colliders, such as the LHC, semileptonic decays of heavy flavor hadrons provide a substantial contribution to the dilepton continuum. The dilepton continuum can give quantitative information about heavy quark yields and their modification in the medium and thus it is important to know all different sources which populate the continuum. In the present study, we calculate $c \bar c$ and $b \bar b$ production and determine their contributions to the dilepton continuum in Pb+Pb collisions at $\sqrt{s_{_{NN}}} = 2.76$ TeV with and without including heavy quark energy loss. We also calculate the rates for Drell-Yan and thermal dilepton production. The contributions to the continuum from these dilepton sources are studied in the kinematic ranges relevant for the LHC detectors. The relatively high $p_T$ cutoff for single leptons excludes most dileptons produced by the thermal medium. Heavy flavors are the dominant source of dilepton production in all the kinematic regimes except at forward rapidities where Drell-Yan start dominating in high mass range beyond 10 GeV/$c^2$.
description: 18 pages, 9 figures
Stopping times are hitting times: a natural representation
Creators: name: Fischer, Tom
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G40, 97K50, 97K60

description: There exists a simple, didactically useful one-to-one relationship between stopping times and adapted càglàd (LCRL) processes that are non-increasing and take the values 0 and 1 only. As a consequence, stopping times are always hitting times.
title: Rapid detection of functional human cytomegalovirus-specific CD8+ T cells via integrin activation
Creators: name: Letz, Philine
name: Grasshoff, Hanna
name: Pitann, Silke
name: Dimitrov, Stoyan
name: Müller, Antje
name: Riemekasten, Gabriela
name: Lange, Tanja
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: CD8+ cytotoxic T cells are involved in the pathogenesis of systemic sclerosis (SSc) [ref:1]. Cytomegalovirus (CMV)-specific CD8+ T cells that adhere to the endothelium by means of activated integrins and drive inflammation, may contribute to vasculopathy in SSc. CMV-specific[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
MPEC 2023-X112 : 2013 GA137
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
The Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Apoptosis in Rat Offspring's Eye Retina
Creators: name: Elnaz Khordad
name: Alireza Fazel
name: Alireza Ebrahimzadeh Bideskan
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Acyclic systems of permutations and fine mixed subdivisions of simplices
Creators: name: Ardila, Federico
name: Ceballos, Cesar
Publisher: name: arXiv
Year: 2011
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: G.2.1
subject: 52C99

description: A fine mixed subdivision of a (d-1)-simplex T of size n gives rise to a system of ${d \choose 2}$ permutations of [n] on the edges of T, and to a collection of n unit (d-1)-simplices inside T. Which systems of permutations and which collections of simplices arise in this way? The Spread Out Simplices Conjecture of Ardila and Billey proposes an answer to the second question. We propose and give evidence for an answer to the first question, the Acyclic System Conjecture. We prove that the system of permutations of T determines the collection of simplices of T. This establishes the Acyclic System Conjecture as a first step towards proving the Spread Out Simplices Conjecture. We use this approach to prove both conjectures for n=3 in arbitrary dimension.
description: 29 pages, 22 figures
Associated Production of a KK-Graviton with a Higgs Boson via Gluon Fusion at the LHC
Creators: name: Shivaji, Ambresh
name: Mitra, Subhadip
name: Agrawal, Pankaj
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In order to solve the hierarchy problem, several extra-dimensional models have received considerable attention. We have considered a process where a Higgs boson is produced in association with a KK-graviton ($G_{\rm KK}$) at the LHC. At the leading order, this process occurs through gluon fusion mechanism $gg \to h G_{\rm KK}$ via a quark loop. We compute the cross section and examine some features of this process in the ADD model. We find that the quark in the loop does not decouple in the large quark-mass limit just as in the case of $gg\to h$ process. We compute the cross section of this process for the case of the RS model also. We examine the feasibility of this process being observed at the LHC.
description: 18 pages, 11 figures. Calculation in the Higgs effective theory framework added
title: Anti-ADRB2 antibodies in systemic sclerosis affect the inflammatory cytokine response of immune cells
Creators: name: Mackedanz, Paulina
name: Graßhoff, Hanna
name: Lange, Tanja
name: Comdühr, Sara
name: Heidecke, Harald
name: Müller, Antje
name: Riemekasten, Gabriela
name: Schumann, Anja
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Antibodies directed against G protein-coupled receptors are altered in patients with systemic sclerosis (SSc) and may serve as biomarker [ref:1], [ref:2]. Agonistic signaling through the β2-adrenoceptor (ADRB2) induces an anti-inflammatory response mainly via [for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
De Sitter Universe in Nonlocal Gravity
Creators: name: Elizalde, E.
name: Pozdeeva, E. O.
name: Vernov, S. Yu.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A nonlocal gravity model, which does not assume the existence of a new dimensional parameter in the action and includes a function $f(\Box^{-1} R)$, with $\Box$ the d'Alembertian operator, is considered. The model is proven to have de Sitter solutions only if the function f satisfies a certain second-order linear differential equation. The de Sitter solutions corresponding to the simplest case, an exponential function f, are explored, without any restrictions on the parameters. If the value of the Hubble parameter is positive, the de Sitter solution is stable at late times, both for negative and for positive values of the cosmological constant. Also, the stability of the solutions with zero cosmological constant is discussed and sufficient conditions for it are established in this case. New de Sitter solutions are obtained which correspond to the model with dark matter and stability is proven in this situation for nonzero values of the cosmological constant.
description: 20 pages, version to appear in Phys. Rev. D
title: B cells synthesize, sense and transport catecholamines to autonomously modulate regulatory B cell function
Creators: name: Honke, Nadine
name: Opgenoorth, Birgit
name: Schneider, Matthias
name: Pongratz, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Catecholamines provided by the sympathetic nervous system (SNS) promote anti-inflammatory regulatory B cells (Bregs), thus strongly influence the development and severity of inflammatory diseases like the rheumatoid arthritis (RA). However, during chronic inflammation the source of catecholamines[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Predictors of Student Success in an Entry-Level Baccalaureate Dental Hygiene Program
Creators: name: Alzahrani, Mohammad J.
Publisher: name: Old Dominion University Libraries
Year: 2005

description: The purpose of this study was to measure the utility of a variety of predictors that have been used by the Old Dominion University, Gene W. Hirschfeld School of Dental Hygiene and other baccalaureate dental hygiene programs in selecting dental hygiene students who are most likely to graduate and be successful in passing the National Board Dental Hygiene Examination (NBDHE). Specifically this study attempted to determine whether or not the following factors are reliable predictors of success in a an entry-level baccalaureate dental hygiene program as evidenced by graduation and successful entry into the profession as evidenced by passing the NBDHE: incoming grade point average (I-GPA); grade point average in prerequisite science courses (S-GPA); Admissions Points Index rating (API); final grade in prerequisite science courses: chemistry I and II, human anatomy and physiology I and II, and microbiology; final grades in first year dental hygiene courses: oral anatomy and histology and oral pathology; multiple attempts to achieve a passing final grade in prerequisite science courses; and the academic setting where these prerequisite science courses were completed.

The sample selected for study consisted of the academic records of dental hygiene students who were admitted to the Old Dominion University, Gene W. Hirschfeld School of Dental Hygiene for the academic years 1998 to 2002 (N=235), who would have been eligible to take the NBDHE during the years 2000 to 2004. Data were obtained from admissions documents and department records.

Data were analyzed using multiple logistic regression with a pre-determined level of significance (p = 0.05) to determine whether or not these variables predict success in an entry-level baccalaureate dental hygiene program as measured by graduation from a dental hygiene program. Data analysis revealed that final course grade in oral pathology is a significant predictor of success (p = 0.0008).

When the NBDHE is a criterion variable, data were analyzed using the multiple linear regression model with a pre-determined level of significance (p = 0.05) to determine whether or not these variables predict success in an entry-level baccalaureate dental hygiene program as measured by the NBDHE score. Data analysis revealed that final course grade in oral pathology; final course grade in oral anatomy and histology; and the Admission Point Index rating (API) are predictors of success on the NBD HE (p < .0001, p < .0001, and p = 0.0245 respectively).
Effect of Heavy Metals on Silencing of Engineered Long Interspersed Element-1 Retrotransposon Retrotransposon in Nondividing Neuroblastoma Cell Line
Creators: name: Habibi, Laleh
name: Shokrgozar, Mohammad Ali
name: Mahdieh Motamedi
name: Akrami, Seyed Mohammad
Publisher: name: the Pasteur Institute of Iran
Year: 1996
Subjects: subject: Basic Sciences

description: Iranian Biomedical Journal (IBJ); ISSN 1028-852X
Stability of the 3-form field during inflation
Creators: name: De Felice, Antonio
name: Karwan, Khamphee
name: Wongjun, Pitayuth
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider the minimally coupled 3-form field which has been considered as a candidate to realize inflation. We have studied the conditions to avoid ghosts and Laplacian instabilities and found that some classes of potentials, e.g. the Mexican-hat one, will in general be unstable. We then propose other classes of potentials which are instead free from any instability, drive a long-enough slow-roll regime followed by an oscillatory epoch, and as a consequence, can provide successful inflation. Finally, we also provide stable potentials which lead to a small enough propagation speed for the scalar perturbations, giving a possibility for these models to produce non-Gaussianities.
description: 18 pages, 12 figures, add new informations in V2, correct some typos in V3
Dictyocaulus Filaria and Muellerius capillaris are Important Lungworm Parasites of Sheep in Wogera District, Northern Ethiopia
Creators: name: 1, 2Nibret Moges, 2Basaznew Bogale And 2Mersha Chanie
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2012

description: No abstract available for this resource
Minimal elements of stopping time $σ$-algebras
Creators: name: Fischer, Tom
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G40, 97K50, 97K60

description: We show how minimal elements of a stopping time $σ$-algebra can be expressed in terms of the minimal elements of the $σ$-algebra of the underlying filtration. This facilitates an intuitive interpretation of stopping time $σ$-algebras. An example is provided.
Nematicidal action of Clonostachys rosea against Meloidogyne incognita: in-vitro and in-silico analyses
Creators: name: Nagaraj, Gowrisri
name: Kannan, Rengasamy
name: Raguchander, Thiruvengadam
name: Narayanan, Swarnakumari
name: Saravanakumar, Duraisamy
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Clonostachys rosea is a biocontrol agent against a wide range of pests and diseases. In the present study, an in-vitro nematicidal activity of C. rosea has been documented by observing the behavioural response of Meloidogyne incognita (Mi) towards the culture filtrate of C. rosea. Eleven different biomolecules observed in GC-MS analysis were tested against seven potential target proteins of Mi through molecular modelling using PyRx 0.8 software. Among the biomolecules tested, Dihydro-4-hydroxy-2(3H)-furanone had the highest binding affinity for Acetylcholine esterase (AchE) (−7.5 kcal/mol), Cytochrome c oxidase subunit 1 (COX) (−7.8 kcal/mol), Heat shock protein (Hsp90) (−8.4 kcal/mol), Odorant response gene 1 (ODR 3) (−6.5 kcal/mol), Neuropeptide G-protein coupled receptor (nGPCR) (−7.6 kcal/mol) and Cathepsin L-protease (cpl-1) (−6.8 kcal/mol) protein targets compared to synthetic pesticide, carbofuran. The biomolecule 2,3-dihydroxypropanal has shown the highest binding affinity for Odorant response gene 1 (ODR 1) (−6.6 kcal/mol). Understanding the interactions between the target protein-ligands docked complexes displayed additional contacts such as hydrophobic interactions, van der Waals, pi-pi stacking, alkyl and pi-alkyl. The present investigation demonstrated that C. rosea is a hub of potential biomolecules that could be explored for nematicidal activities.
Crystal structure, local structure, and defect structure of Pr-doped SrTiO$_3$
Creators: name: Sluchinskaya, I. A.
name: Lebedev, A. I.
name: Erko, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: X-ray diffraction studies showed that the structure of (Sr$_{1-x}$Pr$_x$)TiO$_3$ solid solutions at 300 K changes from the cubic $Pm3m$ to the tetragonal $I4/mcm$ with increasing $x$. The analysis of XANES and EXAFS spectra of the solid solutions revealed that Pr ions are predominantly in the 3+ oxidation state, they substitute for Sr atoms and are on-center regardless of the preparation conditions. The weak dependence of the lattice parameter in (Sr$_{1-x}$Pr$_x$)TiO$_3$ on the Pr concentration was explained by the competition between the relaxation of the Sr--O bond length, which results from the difference in ionic radii of Sr and Pr ions, and the repulsion of positively charged Pr$^{3+}$ and Ti$^{4+}$ ions. It was shown that the most important defects in the crystals are charged Sr vacancies and SrO planar faults; praseodymium does not enter the Sr sites in the planar faults.
description: 6 pages, 4 figures, 1 table
The effects of mammary tumours on hematopoiesis and dendritic cell development
Creators: name: Sio, Alexander
Publisher: name: University of British Columbia
Year: 2015

description: Tumours are often associated with defects in hematopoiesis and DC function. Leukocytosis, anemia, development of immunosuppressive cells such as MDSCs and tolerogenic DCs are all part of tumour development. In breast cancer, although these hematopoietic and DC defects may serve as prognostic indicators, little is known about their origin. Our studies show that mammary tumours affect the hematopoietic system leading to myeloproliferative-like disease characterized by neutrophilia, anemia, and defects in the HSPC compartment. These defects were associated with changes in global epigenetic regulation, and specifically in the upregulation and histone methylation status of Hoxa genes, most notably Hoxa9, a gene that critically controls HSPC differentiation. These changes in gene regulation and HSPC defects were found to be driven by tumour-secreted G-CSF. Additionally, our research shows that the generation of immunosuppressive DCs in mammary tumour bearing mice was associated with impaired DC differentiation, where DCs that develop in the presence of mammary tumours and their factors acquire immunosuppressive features. G-CSF played an important role in the suppression of DC development. Tumour derived factors induced FLT3L and GMCSF DCs to expression Arginase-I, an enzyme known to suppress T cell proliferation and induce tolerance. Our data revealed the expression of Arg1 in these DCs was associated with enabling histone modifications in the Arg1 locus. Targeting of G-CSF may alleviate tumourinduced symptoms of anemia, leukocytosis, and DC defects, resulting in better patient survival and preventing DC immunosuppression.
Ordinary representations of G(Q_p) and fundamental algebraic representations
Creators: name: Breuil, Christophe
name: Herzig, Florian
Publisher: name: arXiv
Year: 2012
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 22E50, 11F80, 11F70

description: Let G be a split connected reductive algebraic group over Q_p such that both G and its dual group G-hat have connected centres. Motivated by a hypothetical p-adic Langlands correspondence for G(Q_p) we associate to an n-dimensional ordinary (i.e. Borel valued) representation rho : Gal(Q_p-bar/Q_p) to G-hat(E) a unitary Banach space representation Pi(rho)^ord of G(Q_p) over E that is built out of principal series representations. (Here, E is a finite extension of Q_p.) Our construction is inspired by the "ordinary part" of the tensor product of all fundamental algebraic representations of G. There is an analogous construction over a finite extension of F_p. In the latter case, when G=GL_n we show under suitable hypotheses that Pi(rho)^ord occurs in the rho-part of the cohomology of a compact unitary group. We also prove a weaker version of this result in the p-adic case.
description: Revised (June 2014), 78 pages
title: Rheuma-VOR: Verbesserung der rheumatologischen Versorgungsqualität durch koordinierte Kooperation
Creators: name: Schwarting, Andreas
name: Dreher, Matthias
name: Assmann, Gunter
name: Witte, Torsten
name: Hoeper, Kirsten
name: Triantafyllias, Konstantinos
name: Murawski, Niels
name: Karberg, Kirsten
name: Proft, Fabian
name: Poddubnyy, Denis
name: Zeidler, Jan
name: Binder, Harald
name: Grodd, Marlon
name: Graf, Erika
name: Callhoff, Johanna
name: Schmidt, Reinhold Ernst
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Rheuma-VOR ist die größte Versorgungsforschungsstudie in Deutschland, mit dem Ziel, in vier Bundesländern drei entzündlich-rheumatische Erkrankungsbilder, die Rheumatoide Arthritis (RA), die Psoriasis Arthritis (PsA) und die axiale Spondyolarthritis (axSpA) möglichst[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Spin before mass at the LHC
Creators: name: Melia, Tom
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: What can be said about the spin of new particles without knowing their mass during an initial discovery phase at CERN? We consider this question in a topology where mass measurement is particularly difficult, $pp\to Y\bar{Y}\to lX\bar{l}\,\bar{X}$, and introduce two new variables $\ctv$ and $\Av$ which we prove are both independent of the mass of $X$. The variable $\ctv$ approximates the polar production angle of $Y$, and we find that it possesses greater statistical power in determining the spin of this particle than a previous, related variable, $\ctll$ \cite{Barr:2005dz}. $\Av$ is an asymmetry which can provide information about the couplings of a spin half $Y$. Because these variables can be used from the outset, without any knowledge of the masses of the new particles, we find here that it is possible to reverse the usual `mass before spin' determination timeline.
description: v2 JHEP version - minor changes to typesetting and some phrasing
Classification and analysis of two dimensional abelian fractional topological insulators
Creators: name: Levin, Michael
name: Stern, Ady
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a general framework for analyzing fractionalized, time reversal invariant electronic insulators in two dimensions. The framework applies to all insulators whose quasiparticles have abelian braiding statistics. First, we construct the most general Chern-Simons theories that can describe these states. We then derive a criterion for when these systems have protected gapless edge modes -- that is, edge modes that cannot be gapped out without breaking time reversal or charge conservation symmetry. The systems with protected edge modes can be regarded as fractionalized analogues of topological insulators. We show that previous examples of 2D fractional topological insulators are special cases of this general construction. As part of our derivation, we define the concept of "local Kramers degeneracy" and prove a local version of Kramers theorem.
description: 19 pages, 2 figures, added reference, corrected typos
title: Strukturierte digitale Erstanamnese im rheumatologischen Praxisalltag
Creators: name: Detert, Jacqueline
name: Brinkhues, Sven
name: Detert, Markus
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Im Flächenland Brandenburg ist die rheumatologische Versorgung für Neu- und Therapiepatienten eine logistisch-organisatorische Herausforderung in der zeitnahen Diagnostik und Terminplanungen. Das Management für Patienten:innen mit rheumatologischen Symptomen kann durch digitale[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Small spectral radius and percolation constants on non-amenable Cayley graphs
Creators: name: Juschenko, Kate
name: Nagnibeda, Tatiana
Publisher: name: arXiv
Year: 2012
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: Motivated by the Benjamini-Schramm non-unicity of percolation conjecture we study the following question. For a given finitely generated non-amenable group $Γ$, does there exist a generating set $S$ such that the Cayley graph $(Γ,S)$, without loops and multiple edges, has non-unique percolation, i.e., $p_c(Γ,S)
Cohomology of rigid curves with semi-stable coverings
Creators: name: Imai, Naoki
name: Tsushima, Takahiro
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 11G20, 14G22

description: We construct a semi-stable formal model of a wide open rigid curve with a semi-stable covering, and study the l-adic cohomology of the rigid curve. We describe the l-adic cohomology of the rigid curve using the l-adic cohomology of the irreducible components of a semi-stable reduction, and homology and cohomology of some graphs. We also prove the functoriality of the description for a finite flat morphism that is compatible with semi-stable coverings of wide open rigid curves.
description: 13 pages
title: Unmet medical need bei Diagnose und Management der Psoriasis-Arthritis – Daten einer prospektiven Studie in Deutschland
Creators: name: Groß, Georg
name: Von Ahnen, Jan Alwin
name: Lull, Christian
name: Schmieder, Astrid
name: Leipe, Jan
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Diagnose und Therapie der Psoriasis-Arthritis (PsA) stellen aufgrund der Komplexität der Erkrankung weiterhin eine große Herausforderung dar. Bisherige Daten deuten an, dass die PsA häufig nicht oder erst mit erheblicher Verzögerung diagnostiziert und behandelt wird[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
"Left him in the dust:" father exclusion from maternal harm reduction services
Creators: name: Weaver, Sydney Michelle
Publisher: name: University of British Columbia
Year: 2013

description: This study was conducted in Vancouver, B.C., Canada, with former patients of a harm reduction maternity ward serving pregnant women who use illicit drugs in Vancouver’s downtown eastside. This district is one of Canada’s poorest urban neighbourhoods. The purpose of this study was to build theory, based on how fathers and mothers were affected by father exclusion, to inform development of more effective services for substance-using parents. The study demonstrates how father exclusion from services offered at a harm reduction hospital maternity unit affects fathers and mothers struggling with problematic drug use. A qualitative approach, constructivist grounded theory, was used. A purposeful sampling method was employed to recruit 20 parents, 10 mothers and 10 fathers, for individual interviews and a focus group. Grounded theory method highlighted how structural conditions of addictions services recursively interact with experiences of fathers and mothers, amplifying obstacles experienced by parents using illicit drugs, such as poverty, stigma, racism and homelessness. Fathers’ gender-based exclusion compounded feelings of exclusion based on race and class, and negatively affected mothers. The study findings: contest the tenets of ‘difference’ feminist theory that underpin contemporary addictions services for women; demonstrate the importance of including fathers in antenatal, natal and postnatal addictions services; and contribute to theory aimed at disrupting and destabilizing gender norms.
How many times do (super-)centenarians beat the odds of dying? An application to gender differences in the USA.
Creators: name: di Lego, Vanessa
name: Remund, Adrien
Publisher: name: Zenodo
Year: 2024

description: How many times does somebody need to cheat death in order to become a centenarian? How many additional times do centenarians need to beat the odds to become super-centenarians? Usual measures of longevity do not answer these questions, while more people are reaching ages that used to be considered exceptional. Instead of focusing on the mean or variation in lifespans, we ask the following question: what are the odds of beating one’s expected age at death in order to attain (very) old age?

Because the probability to repeatedly attain the expected age at death converges to e-1, as the number of times one beats the odds of dying increases, the number of lives needed to reach a target age a can be approximated as n(a) ≈ 1.5 - ln(l(a)), where l(a) is the probability to reach this age (Remund & di Lego, forthcoming). We apply this relationship to US cohort life tables from the Social Security Administration and compute the number of times men and women of the 1900 and 1910 birth cohorts cheated death before becoming centenarians and supercentenarians.

Preliminary results show that an American woman born in 1900 had to cheat death on average 5.5 times in order to become centenarian, and then again 5.5 times to become supercentenarian. This implies that the challenge to reach the age of 100 from birth is similar to the challenge of reaching 110 for centenarians in this cohort, in terms of successively outliving their expected age at death. Hence, the effort it takes to avoid death in the 10 years to reach age 110 for a centenarian is similar to the lifelong effort of a newborn to reach age 100.

Men, on the other hand, had to beat the odds two more times than women in order to become centenarians (they outlived their expected age at death 7.5 times on average), but the challenge to become supercentenarian is closer to the one experienced by women. These results do not differ significantly for the 1910 birth cohort. In the final paper, we will decompose the gender and cohort gaps by age using numerical decomposition techniques.
Non-monogamy of quantum discord and upper bounds for quantum correlation
Creators: name: Ren, Xi-Jun
name: Fan, Heng
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider a monogamy inequality of quantum discord in a pure tripartite state and show that it is equivalent to an inequality between quantum mutual information and entanglement of formation of two parties. Since this inequality does not hold for arbitrary bipartite states, quantum discord can generally be both monogamous and polygamous. We also carry out numerical calculations for some special states. The upper bounds of quantum discord and classical correlation are also discussed and we give physical analysis on the invalidness of a previous conjectured upper bound of quantum correlation. Our results provide new insights for further understanding of distributions of quantum correlations.
description: Title changed, abstract and introduction revised, references added
Proof of the Pruning Front Conjecture for certain Hénon parameters
Creators: name: Mendoza, Valentín
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: The Pruning Front Conjecture is proved for an open set of Hénon parameters far from unimodal. More specifically, for an open subset of Hénon parameter space, consisting of two connected components one of which intersects the area-preserving locus, it is shown that the associated Hénon maps are prunings of the horseshoe. In particular, their dynamics is a subshift of the two-sided two-shift.
title: Prospektive Analyse von obstruktiver Schlafapnoe bei Patienten mit Erstdiagnose einer rheumatoiden Arthritis, Psoriasis Arthritis und peripherer Spondylarthritis – eine Screening-Studie
Creators: name: Dejcman, Daniel
name: Skowasch, Dirk
name: Pizarro, Carmen
name: Brossart, Peter
name: Karakostas, Pantelis
name: Schäfer, Valentin
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Eine erhöhte Prävalenz der obstruktiven Schlafapnoe (OSA) bei Patienten mit rheumatoider Arthritis (RA), Psoriasisarthritis (PsA) und zum Teil bei peripherer Spondylarthritis (pSpA) ist in der Literatur hinreichend beschrieben worden. Aktuell gibt es keine Polygraphie-gestützte,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
12 years of X-ray variability in M31 globular clusters, including 8 black hole candidates, as seen by Chandra
Creators: name: Barnard, R.
name: Garcia, M.
name: Murray, S. S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We examined 134 Chandra observations of the population of X-ray sources associated with globular clusters (GCs) in the central region of M31. These are expected to be X-ray binary systems (XBs), consisting of a neutron star or black hole accreting material from a close companion. We created long-term lightcurves for these sources, correcting for background, interstellar absorption and instrumental effects. We tested for variability by examining the goodness of fit for the best fit constant intensity. We also created structure functions (SFs) for every object in our sample, the first time this technique has been applied to XBs. We found significant variability in 28 out of 34 GCs and GC candidates; the other 6 sources had 0.3--10 keV luminosities fainter than ~2E+36 erg/s, limiting our ability to detect similar variability. The SFs of XBs with 0.3--10 keV luminosities ~2--50 E+36 generally showed considerably more variability than the published ensemble SF of AGN. Our brightest XBs were mostly consistent with the AGN SF; however, their 2--10 keV fluxes could be matched by <1 AGN per square degree. These encouraging results suggest that examining the long term lightcurves of other X-ray sources in the field may provide an important distinction between X-ray binaries and background galaxies, as the X-ray emission spectra from these two classes of X-ray sources are similar. Additionally, we identify 3 new black hole candidates (BHCs) using additional XMM-Newton data, bringing the total number of M31 GC BHCs to 9, with 8 covered in this survey.
description: Accepted for publication in ApJ; 30 pages, 16 figures, 3 tables
title: Das Sarcoidosis-Lymphoma Syndrome als seltene Entität bei Patienten mit systemischer Symptomatik – eine systematische Literaturübersicht
Creators: name: Korsten, Peter
name: Schubert, Nils
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Sarkoidose ist eine Systemerkrankung unklarer Ätiologie, die gekennzeichnet ist durch die Bildung nicht-verkäsender Granulome und konsekutiver Entzündung in verschiedenen Organen mit potentieller Schödigung und Funktionsverlust der betroffenen Organe. Manchmal kann[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Prevalence and Incidence of Adamantiades-Behçet’s Disease: An Epidemiological Study from Germany
Creators: name: Zouboulis, Christos C.
name: Stein, Alexandra
name: Medelnik, Jan-Philip
name: Heinrich, Ria
name: Galetzka, Wolfgang
name: Borchert, Julia
name: Diesing, Joanna
name: Schönfelder, Tonio
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Adamantiades-Behçet’s disease (ABD) is a rare chronic, multisystem, inflammatory disease, characterized by chronic vasculitis and a relapsing-remitting course of mucocutaneous and ocular lesions. Oral ulcers are the most common manifestations and significantly impair quality[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Fermi polarons in two dimensions
Creators: name: Schmidt, Richard
name: Enss, Tilman
name: Pietilä, Ville
name: Demler, Eugene
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically analyze inverse radiofrequency (rf) spectroscopy experiments in two-component Fermi gases. We consider a small number of impurity atoms interacting strongly with a bath of majority atoms. In two-dimensional geometries we find that the main features of the rf spectrum correspond to an attractive polaron and a metastable repulsive polaron. Our results suggest that the attractive polaron has been observed in a recent experiment [Phys. Rev. Lett. 106, 105301 (2011)].
description: 6 pages, 7 figures
title: Alles nur Kopfsache? Gründe für frühe Berentung bei Patienten mit primärem Sjögren-Syndrom
Creators: name: Beider, Sonja
name: Witte, Torsten
name: Ernst, Diana
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Patienten mit primärem Sjögren-Syndrom (pSS) leiden unter Sicca Symptomatik sowie häufig zusätzlich an extraglandulären Manifestationen wie Fatigue, Schmerzen oder Organmanifestationen. Psychische Störungen wurden ebenfalls häufig bei Patienten mit pSS [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Gender-Awareness in axialer Spondyloarthritis: Screeningsprechstunde erreicht vermehrt axSpA-Patientinnen
Creators: name: Hansen, Oliver
name: Lion, Vivienne
name: Lorenz, Hanns-Martin
name: Benesova, Karolina
Publisher: name: German Medical Science GMS Publishing House
Year: 2021
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die zunehmende Erforschung geschlechtsspezifischer Unterschiede in der Medizin rückt auch die axiale Spondyloarthritis (axSpA) ins neue Licht: die differenziertere Betrachtung zeigt eine hohe Prävalenz unterdiagnostizierter Patientinnen aufgrund von abweichender Symptompräsentation,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Higgs boson mass and new physics
Creators: name: Bezrukov, Fedor
name: Kalmykov, Mikhail Yu.
name: Kniehl, Bernd A.
name: Shaposhnikov, Mikhail
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the lower Higgs boson mass bounds which come from the absolute stability of the Standard Model (SM) vacuum and from the Higgs inflation, as well as the prediction of the Higgs boson mass coming from asymptotic safety of the SM. We account for the 3-loop renormalization group evolution of the couplings of the Standard Model and for a part of two-loop corrections that involve the QCD coupling alpha_s to initial conditions for their running. This is one step above the current state of the art procedure ("one-loop matching--two-loop running"). This results in reduction of the theoretical uncertainties in the Higgs boson mass bounds and predictions, associated with the Standard Model physics, to 1-2 GeV. We find that with the account of existing experimental uncertainties in the mass of the top quark and alpha_s (taken at 2sigma level) the bound reads M_H>=M_min (equality corresponds to the asymptotic safety prediction), where M_min=129+-6 GeV. We argue that the discovery of the SM Higgs boson in this range would be in agreement with the hypothesis of the absence of new energy scales between the Fermi and Planck scales, whereas the coincidence of M_H with M_min would suggest that the electroweak scale is determined by Planck physics. In order to clarify the relation between the Fermi and Planck scale a construction of an electron-positron or muon collider with a center of mass energy ~200+200 GeV (Higgs and t-quark factory) would be needed.
description: Version accepted in JHEP, including note added regarding theoretical end experimental results that appeared since the original version of the paper. Additional computer code can be found at http://www.inr.ac.ru/~fedor/SM/