cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Antioxidant activity and characterization of flavonoids and phenolic acids of Ammoides atlantica by RP–UHPLC–ESI–QTOF–MSn
Creators: name: Benteldjoune, Mounira
name: Boudiar, Tarek
name: Bakhouche, Abdelhakim
name: del Mar Contreras, María
name: Lozano-Sánchez, Jesús
name: Bensouici, Chawki
name: Kabouche, Zahia
name: Segura-Carretero, Antonio
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: In this study, phytochemical profiling of hydro-alcoholic extract of Ammoides atlantica aerial parts has been carried out using RP-UHPLC-ESI-QTOF-MS in negative ionization mode Chemical characterization was established according to the MS and MS/MS spectra. A total of 66 chemical compounds were detected. Among these, 45 compounds were identified: hydroxycinnamic acid and derivatives (26), hydroxybenzoic acids (4), flavones (11), flavonols (3), and a lignan. Total phenolics (371.57 mg/g) and total flavonoids (41.02 mg/g) contents were also determined. Moreover, the antioxidant activity of A. atlantica extract was also studied by six methods: DPPH (IC50: 23.31 µg/mL), ABTS+ (IC50: 11.31 µg/mL), O2- DMSO alkaline (IC50: 3.19 µg/mL), ferrous ions chelating assays (IC50: 102.35 µg/mL), reducing power (A0.50: 92.70 µg/mL) and CUPRAC (A0.50: 13.56 µg/mL) assays. These results suggest that the antioxidant activity of the hydroalcoholic extract was comparable to common antioxidant additives in most of the tests, representing a good alternative.
The transition to chaos of coupled oscillators: An operator fidelity susceptibility study
Creators: name: Jacobson, N. Tobias
name: Giorda, Paolo
name: Zanardi, Paolo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The operator fidelity is a measure of the information-theoretic distinguishability between perturbed and unperturbed evolutions. The response of this measure to the perturbation may be formulated in terms of the operator fidelity susceptibility (OFS), a quantity which has been used to investigate the parameter spaces of quantum systems in order to discriminate their regular and chaotic regimes. In this work we numerically study the OFS for a pair of non-linearly coupled two-dimensional harmonic oscillators, a model which is equivalent to that of a hydrogen atom in a uniform external magnetic field. We show how the two terms of the OFS, being linked to the main properties that differentiate regular from chaotic behavior, allow for the detection of this model's transition between the two regimes. In addition, we find that the parameter interval where perturbation theory applies is delimited from above by a local minimum of one of the analyzed terms.
description: 8 pages, 6 figures
Effects of lobetyolin on xanthine oxidase activity in vitro and in vivo: weak and mixed inhibition
Creators: name: Yoon, In-Soo
name: Cho, Seung-Sik
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Lobetyolin (LBT), a general marker compound mainly found in Codonopsis plants including C. pilosula, C. tubulosa, and C. lanceolata, exhibits antitumor, antiviral, anti-inflammatory, mucosal protective, and antioxidant activities. Xanthine oxidase (XO) catalyzes the formation of uric acid from xanthine, a critical metabolic pathway related to hyperuricemia and gout. The aim of this study was to investigate the effect of LBT on XO activity and its mechanism using in vitro enzyme assay system and in vivo potassium oxonate-induced hyperuricemic mice. LBT was found to weakly inhibit XO activity via a mixed type mechanism. Consistently, the impact of 1-week oral LBT treatment on serum XO activity in vivo is limited in hyperuricemic mice. However, oral LBT at 50 mg/kg significantly reduced hepatic XO activity in vivo. To the best of our knowledge, this is the first study to report effects of LBT on XO activity and its inhibition mechanism.
Trial wavefunctions for the Goldstone mode in ν=1/2+1/2 quantum Hall bilayers
Creators: name: Moller, Gunnar
name: Simon, Steven H.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Based on the known physics of the excitonic superfluid or 111 state of the quantum Hall ν=1/2+1/2 bilayer, we create a simple trial wavefunction ansatz for constructing a low energy branch of (Goldstone) excitations by taking the overall ground state and boosting one layer with respect to the other. This ansatz works extremely well for any interlayer spacing. For small d this is simply the physics of the Goldstone mode, whereas for large d this is a reflection of composite fermion physics. We find hints that certain aspects of composite fermion physics persist to low d whereas certain aspects of Goldstone mode physics persist to high d. Using these results we show nonmonotonic behavior of the Goldstone mode velocity as a function of d.
description: 6 pages, 4 figures
Renormalized Polyakov loop in the Fixed Scale Approach
Creators: name: Gavai, Rajiv V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: I compute Polyakov loop, the deconfinement order parameter, for SU(2) lattice gauge theory using the fixed scale approach for several different scales and show how to obtain a renormalized physical order parameter. The generalization to other gauge theories, including quenched or full QCD, is straightforward.
description: 7 pages, 5 figures. To appear in the Proceedings of the 28th International Symposium on Lattice Field Theory (Lattice 2010), Villasimius, Sardinia, Italy, June 14-19, 2010 (Nonzero Temperature and Density)
Large Exomoons unlikely around Kepler-1625 b and Kepler-1708 b
Creators: name: Heller, René
name: Hippke, Michael
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: There are more than 200 moons in our Solar System, but their relatively small radii make similarly sized extrasolar moons very hard to detect with current instruments. The best exomoon candidates so far are two nearly Neptune-sized bodies orbiting the Jupiter-sized transiting exoplanets Kepler-1625 b and Kepler-1708 b, but their existence has been contested. Here we reanalyse the Hubble and Kepler data used to identify the two exomoon candidates employing nested sampling and Bayesian inference techniques coupled with a fully automated photodynamical transit model. We find that the evidence for the Kepler-1625 b exomoon candidate comes almost entirely from the shallowness of one transit observed with Hubble. We interpret this as a fitting artifact in which a moon transit is used to compensate for the unconstrained stellar limb darkening. We also find much lower statistical evidence for the exomoon candidate around Kepler-1708 b than previously reported. We suggest that visual evidence of the claimed exomoon transits is corrupted by stellar activity in the Kepler light curve. Our injection-retrieval experiments of simulated transits in the original Kepler data reveal false positive rates of 10.9% and 1.6% for Kepler-1625 b and Kepler-1708 b, respectively. Moreover, genuine transit signals of large exomoons would tend to exhibit much higher Bayesian evidence than these two claims. We conclude that neither Kepler-1625 b nor Kepler-1708 b are likely to be orbited by a large exomoon.
description: published in Nature Astronomy, 46 pages, 4 Figures (in color), 10 Supplementary Figures (3 in color, 7 in black/white), 5 Supplementary Tables
Klima-Kippelemente: Wieviel Erwärmung ist zu viel
Creators: name: von der Heydt, Anna
Publisher: name: Zenodo
Year: 2022

description: Online Vortrag
 Industriegespräche Bremen https://www.dpg-physik.de/veranstaltungen/2022/klima-kippelemente
description: This work was partly carried out under the umbrella of the Netherlands Earth System Science Centre (NESSC), financially supported by the Dutch Ministry of Education, Culture and Science (OCW).
Bioprospection for antiplasmodial activity, and identification of bioactive metabolites of native plants species from the Mata Atlântica biome, Brazil
Creators: name: Gontijo, Douglas Costa
name: Leite, João Paulo Viana
name: Nascimento, Maria Fernanda Alves do
name: Brandão, Geraldo Célio
name: de Oliveira, Alaíde Braga
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: A total of 33 extracts of eleven different plants species from Mata Atlântica biome, Brazil, and different fractions of the bioactive extracts were evaluated against chloroquine-resistant Plasmodium falciparum W2 strain by PfLDH method and cytotoxicity to HepG2 cells by the MTT assay, and chemically characterized by LC-DAD-ESI-MS/MS analysis. The results allowed the identification of Alchornea glandulosa, Miconia latecrenata, and Psychotria suterella as the most active plant species. Different flavonoids and tannins in Alchornea glandulosa and Miconia latecrenata besides alkaloids in Psychotria suterella were identified. Bioguided fractionation of A. glandulosa and M. latecrenata leaves extracts led to fractions exhibiting high parasite growth inhibition. Seven known alkaloids were identified in the P. suterella extract, and of these, only 5-carboxystrictosidine had been assayed for antiplasmodial activity what points to this species as the most promising among the eleven one assayed.
Detector developments for the hypernuclear programme at PANDA
Creators: name: Achenbach, P.
name: Pochodzalla, J.
name: Lorente, A. Sanchez
name: Majos, S. Sánchez
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The technical design of the PANDA experiment at the future FAIR facility next to GSI is progressing. At the proposed anti-proton storage ring the spectroscopy of double Lambda hypernuclei is one of the four main topics which will be addressed by the Collaboration. The hypernuclear experiments require (i) a dedicated internal target, (ii) an active secondary target of alternating silicon and absorber material layers, (iii) high purity germanium (HPGe) detectors, and (iv) a good particle identification system for low momentum kaons. All systems need to operate in the presence of a high magnetic field and a large hadronic background. The status of the detector developments for this programme is summarized.
description: Contributed to 2008 IEEE Nuclear Science Symposium, 19-25 October 2008, Dresden, Germany
Fluoro Reactands and Dual Luminophore Referencing: A Technique To Optically Measure Amines
Creators: name: Mohr, Gerhard J.
name: Klimant, Ingo
name: Spichiger-Keller, Ursula E.
name: Wolfbeis, Otto S.
Publisher: name: Universität Regensburg
Year: 2001
Subjects: subject: 540 Chemie

description: An optical sensor for aqueous 1-butylamine is presented which combines two novel techniques: A fluorescent indicator dye (fluoro reactand) embedded in a thin polymer layer performs a reversible chemical reaction with the analyte, causing changes in luminescence intensity. At the same time, inert phosphorescent beads dispersed within the polymer layer provide luminescence signals that act as an internal reference for the indicator dye. As a consequence, the optical sensor is independent of light source fluctuations, ambient light, drifts in optoelectronic setup, or optical fiber bending.
Why PQ?
Creators: name: Peccei, R. D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: I discuss how the solution of the $U(1)_A$ problem of QCD through the existence of the $θ$-vacuum gave rise to the strong CP problem. After examining various suggested solutions to this problem, I conclude that the only viable solution still is the one that involves the existence of a spontaneously broken chiral symmetry: $U(1)_{PQ}$
description: Invited talk given at the Axion 2010 Conference, January 15-17, 2010, Univ. of Florida, Gainsville, FL
Determination of natural phenolic compounds of Ferula longipedunculata Peşmen and assessment their antioxidant and anticholinesterase potentials
Creators: name: Karakaya, Songul
name: Koca, Mehmet
name: Sytar, Oksana
name: Duman, Hayri
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The paper reports anticholinesterase and antioxidant activities of extracts, fractions from aerial parts, roots, flowers, fruits of Ferula longipedunculata Peşmen (Apiaceae). Phenolic content, antioxidant activities of samples were carried out using Folin-Ciocalteu, DPPH, TBA methods. Anticholinesterase activity was actualised through Ellman’s method. The utmost and least total phenolic content were detected in root MeOH extract (36.4 mg GAE g−1 DW) and aerial part (23.74 mg GAE g−1 DW), respectively. Hexane fraction of root exhibited significant inhibition against AChE (37.99%) and BuChE (81.66%) at 20 μg/mL as well as remarkable antioxidant and anticholinesterase activities. However, investigations on roots will be substantial for improved usage of F. longipedunculata for pharmaceutical and food search needs.
MPEC 2023-X144 : 2023 XC4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 XC4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Third quantization
Creators: name: Seligman, Thomas H.
name: Prosen, Tomaz
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The basic ideas of second quantization and Fock space are extended to density operator states, used in treatments of open many-body systems. This can be done for fermions and bosons. While the former only requires the use of a non-orthogonal basis, the latter requires the introduction of a dual set of spaces. In both cases an operator algebra closely resembling the canonical one is developed and used to define the dual sets of bases. We here concentrated on the bosonic case where the unboundedness of the operators requires the definitions of dual spaces to support the pair of bases. Some applications, mainly to non-equilibrium steady states, will be mentioned.
description: To appear in the Proceedings of Symposium Symmetries in Nature in memoriam Marcos Moshinsky. http://www.cicc.unam.mx/activities/2010/SymmetriesInNature/index.html
Molecularly imprinted polymers-based colorimetric-SERS dual biosensor for the detection of atrazine in apple juice
Creators: name: Zhao, Bowen
Publisher: name: University of British Columbia
Year: 2017

description: Atrazine is a harmful herbicide that can disrupt the hormonal system in humans and animals. Contamination of atrazine in various agri-food products occurs due to illegal uses. Detection of atrazine in foods is time consuming and expensive when the official methods such as gas chromatography-mass spectrometry are applied. In this thesis project, we developed a dual biosensor integrating molecularly imprinted polymers (MIPs) with gold nanoparticles (AuNPs)-based colorimetric assay and surface enhanced Raman spectroscopy (SERS), which can be applied for rapid, high-throughput and sensitive determination of trace levels of atrazine in agri-food products (e.g., apple juice). This biosensor includes three functions: separation, screening, and quantification. For separation, MIPs were synthesized using molecular imprinting technology by employing atrazine as the template molecule. MIPs-based solid phase extraction (MIPs-SPE) could selectively separate atrazine from apple juice with high recoveries (~93%). AuNPs-based colorimetric assays were able to rapidly detect atrazine due to ligands between atrazine molecules and the surface of AuNPs. High-throughput screening of a large number of samples could be achieved with simple color variation with the limit of detection (LOD) as low as 0.01 mg L-¹. For quantification, SERS tests were conducted using AuNPs for Raman spectral collection. Raman spectra of apple juice samples with different concentrations of atrazine were rapidly collected and analyzed by chemometrics. The calculated LOD equals to 0.0012 mg L-¹ and limit of quantification (LOQ) was 0.0040 mg L-¹, both of which meet the guidelines set up by Health Canada (i.e., 0.005 mg L-¹). Three types of AuNPs with different diameters (i.e., 43 nm, 27 nm, 11 nm) were synthesized and compared for the use of this biosensor. The largest AuNPs worked best for colorimetric assays while the medium-size AuNPs were the most suitable candidate for SERS tests. The extremely low LOD and LOQ strongly validate the potential application of this innovative dual biosensor for accurate and high-throughput determination of atrazine in foods.
Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity
Creators: name: Gohil, Akash R.
name: Deshmukh, Sunil K.
name: Bhattacharya, Vaishali
name: Lavhale, Rahul
name: Verekar, Shilpa
name: Kate, Abhijeet S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Chemical characterization of ethyl acetate extract of Exophiala sp. has afforded the isolation of three compounds including a new isocoumarin named exophiarin (1). Exophiala sp. was obtained from the soil containing dumped organic waste (litter). Initially, LC-UV-MS analysis of the extract of Exophiala sp. revealed the presence of a new compound having molecular weight 438 (1) and previously reported TPI-2 and TPI-5. The novelty was established using advanced database search comprising of biological source, molecular weight and UV profile. 1D, 2D NMR and HRMS data have been used for structure elucidation. Exophiarin with TPI-2 and TPI-5 have displayed moderate improvement in glucose uptake activity when tested in rat skeletal muscle cell line L6.
New anthracene and anthraquinone metabolites from Prismatomeris filamentosa and their antibacterial activities
Creators: name: Wisetsai, Awat
name: Lekphrom, Ratsami
name: Schevenels, Florian T.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: An unusual, new anthracene natural product named filamentos A (1), two new anthraquinone derivatives named filamentos B (2) and C (3), together with sixteen known compounds (4–19), were isolated from the roots of the tree Prismatomeris filamentosa. Their structures were identified by analysis of mass and spectroscopic data (IR, 1D and 2D NMR). Twelve metabolites (1–6, 9, 12–14, 16–17) showed moderate antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria such as B. subtilis, B. cereus, S. aureus, E. coli, P. aeruginosa and S. sonnei.
Antibacterial activity of prenylated benzopyrans from Peperomia obtusifolia (Piperaceae)
Creators: name: Mostacero, Nathalie Ruiz
name: Castelli, María Victoria
name: Cutró, Andrea Carmen
name: Hollmann, Axel
name: Batista, João Marcos
name: Furlan, Maysa
name: Valles, Julieta
name: Fulgueira, Cecilia Luisa
name: López, Silvia Noelí
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Peperomia obtusifolia is a herbaceous perennial plant native to the Americas reported as a traditional medicine to treat snake bites and as a skin cleanser. The bioassay-guided fractionation of crude extracts from aerial parts of P. obtusifolia against a panel of clinically important fungi and bacteria, showed that hexane and dichloromethane extracts demonstrated selective bacterial inhibition, allowing the isolation of the known compounds peperobtusin A (1), and 3,4-dihydro-5-hydroxy-2,7-dimethyl-8-(3”-methyl-2”-butenyl)-2-(4’-methyl-1’,3’-pentadienyl)-2H-1-benzopyran-6-carboxylic acid (2) from dichloromethane extract. Compound 2 was active against Gram-positive bacteria including community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates and an Enterococcus faecalis vancomycin-resistant strain, with minimal inhibitory concentration (MIC) values of 4 μg/mL (10.8 μM) and 8 μg/mL (21.6 μM) respectively. The interaction of compound 2 with the bacterial membrane was demonstrated by means of Zeta potential experiments on S. aureus, then confirming the membrane damage by fluorescent microscopy experiments.
Semi-parametric dynamic time series modelling with applications to detecting neural dynamics
Creators: name: Rigat, Fabio
name: Smith, Jim Q.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: This paper illustrates novel methods for nonstationary time series modeling along with their applications to selected problems in neuroscience. These methods are semi-parametric in that inferences are derived by combining sequential Bayesian updating with a non-parametric change-point test. As a test statistic, we propose a Kullback--Leibler (KL) divergence between posterior distributions arising from different sets of data. A closed form expression of this statistic is derived for exponential family models, whereas standard Markov chain Monte Carlo output is used to approximate its value and its critical region for more general models. The behavior of one-step ahead predictive distributions under our semi-parametric framework is described analytically for a dynamic linear time series model. Conditions under which our approach reduces to fully parametric state-space modeling are also illustrated. We apply our methods to estimating the functional dynamics of a wide range of neural data, including multi-channel electroencephalogram recordings, longitudinal behavioral experiments and in-vivo multiple spike trains recordings. The estimated dynamics are related to the presentation of visual stimuli, to the evaluation of a learning performance and to changes in the functional connections between neurons over a sequence of experiments.
description: Published in at http://dx.doi.org/10.1214/09-AOAS275 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Presentation Description Given by Mary Louise Edwards Dodge, January 19, 1977
Creators: name: Dodge, Mary Louise Edwards
name: Springs Historical Society
Publisher: name: Unknown
Year: 1977
Subjects: East Hampton
Springs
Edwards Family
Public speaking

description: This is a description of a presentation about Springs and Fireplace history given by Mary Louise Edwards Dodge on January 19, 1977. This includes a list of the slide titles shown during the presentation.
description: This material was lent to the Long Island Collection by the Springs Historical Society Library for digitization purposes.
The behaviour of Fenchel-Nielsen distance under a change of pants decomposition
Creators: name: Papadopoulos, Athanase
name: Liu, Lixin
name: Alessandrini, Daniele
name: Su, Weixu
Publisher: name: arXiv
Year: 2011
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: Given a topological orientable surface of finite or infinite type equipped with a pair of pants decomposition $\mathcal{P}$ and given a base complex structure $X$ on $S$, there is an associated deformation space of complex structures on $S$, which we call the Fenchel-Nielsen Teichmüller space associated to the pair $(\mathcal{P},X)$. This space carries a metric, which we call the Fenchel-Nielsen metric, defined using Fenchel-Nielsen coordinates. We studied this metric in the papers \cite{ALPSS}, \cite{various} and \cite{local}, and we compared it to the classical Teichmüller metric (defined using quasi-conformal mappings) and to another metric, namely, the length spectrum, defined using ratios of hyperbolic lengths of simple closed curves metric. In the present paper, we show that under a change of pair of pants decomposition, the identity map between the corresponding Fenchel-Nielsen metrics is not necessarily bi-Lipschitz. The results complement results obtained in the previous papers and they show that these previous results are optimal.
Low Temperature Dynamics of Magnons in a Spin-1/2 Ladder Compound
Creators: name: Náfrádi, B.
name: Keller, T.
name: Manaka, H.
name: Zheludev, A.
name: Keimer, B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have used a combination of neutron resonant spin-echo and triple-axis spectroscopies to determine the energy, fine structure, and linewidth of the magnon resonance in the model spin-1/2 ladder antiferromagnet IPA-CuCl_3 at temperatures T << Delta_0 /k_B, where Delta_0 is the spin gap at T=0. In this low-temperature regime we find that the results deviate substantially from the predictions of the non-linear sigma model proposed as a description of magnon excitations in one-dimensional quantum magnets and attribute these deviations to real-space and spin-space anisotropies in the spin Hamiltonian as well as scattering of magnon excitations from a dilute density of impurities. These effects are generic to experimental realizations of one-dimensional quantum magnets.
description: 4 pages, 4 figures
Microscopic Aspects of Stretched Exponential Relaxation (SER) in Homogeneous Molecular and Network Glasses and Polymers
Creators: name: Phillips, J. C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Because the theory of SER is still a work in progress, the phenomenon itself can be said to be the oldest unsolved problem in science, as it started with Kohlrausch in 1847. Many electrical and optical phenomena exhibit SER with probe relaxation I(t) ~ exp[-(t/τ)β], with 0 < β < 1. Here τ is a material-sensitive parameter, useful for discussing chemical trends. The "shape" parameter β is dimensionless and plays the role of a non-equilibrium scaling exponent; its value, especially in glasses, is both practically useful and theoretically significant. The mathematical complexity of SER is such that rigorous derivations of this peculiar function were not achieved until the 1970's. The focus of much of the 1970's pioneering work was spatial relaxation of electronic charge, but SER is a universal phenomenon, and today atomic and molecular relaxation of glasses and deeply supercooled liquids provide the most reliable data. As the data base grew, the need for a quantitative theory increased; this need was finally met by the diffusion-to-traps topological model, which yields a remarkably simple expression for the shape parameter β, given by d*/(d* + 2). At first sight this expression appears to be identical to d/(d + 2), where d is the actual spatial dimensionality, as originally derived. The original model, however, failed to explain much of the data base. Here the theme of earlier reviews, based on the observation that in the presence of short-range forces only d* = d = 3 is the actual spatial dimensionality, while for mixed short- and long-range forces, d* = fd = d/2, is applied to four new spectacular examples, where it turns out that SER is useful not only for purposes of quality control, but also for defining what is meant by a glass in novel contexts. (Please see full abstract in main text)
Observational constraints on the second-order primordial power spectrum: Exploring a Continuous Spontaneous Localization inspired inflationary model
Creators: name: Piccirilli, Maria Pia
name: Leon, Gabriel
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Inflation, a period of exponential expansion in the early Universe, is considered an important part of the standard $Λ$CDM cosmological model, and plays a crucial role in explaining a wide range of current observations. The standard inflationary model predicts a primordial spectrum of fluctuations that is nearly scale-independent, fitting remarkably well the latest observational data. Nevertheless, there is an ongoing discussion surrounding the transition from an initial homogeneous and isotropic quantum state, characterizing the matter fields during inflation, to a classical inhomogeneous/anisotropic one, which gives rise to large-scale structure in the Universe. To tackle this issue, in the present work we explore an inflationary scenario where quantum ``collapse'' (or reduction) occurs naturally during the evolution of the system; this model is inspired in the so called Continuous Spontaneous Localization (CSL) model. Our present work builds upon previous results by considering the primordial power spectrum up to the second order in the Hubble Flow Functions, where we perform an estimation of the model free parameters. By validating the predictions of the model against observational data, we investigate whether this second-order calculation can explain the slight departure from the power law observed in the scalar spectral running index. We hope this research contributes to the understanding of the quantum-to-classical transition and its implications for cosmology.
description: 30 pages, 9 figures, 3 tables. This version corresponds largely to the accepted version in Phys. of the Dark Univ
Third Harmonic Generation at 223nm in the Metallic Regime of GaP
Creators: name: Roppo, V.
name: Akozbek, J. Foreman N.
name: Vincenti, M. A.
name: Scalora, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate second and third harmonic generation from a GaP substrate 500μm thick. The second harmonic field is tuned at the absorption resonance at 335nm, and the third harmonic signal is tuned at 223nm, in a range where the dielectric function is negative. These results show that a phase locking mechanism that triggers transparency at the harmonic wavelengths persists regardless of the dispersive properties of the medium, and that the fields propagate hundreds of microns without being absorbed even when the harmonics are tuned to portions of the spectrum that display metallic behavior.
In silico analysis of small molecule compounds based on pharmacophore- and backbone-leaping peroxiredoxin 1 (PRDX1) inhibitors
Creators: name: Zheng, Ningying
name: Tan, Huiting
name: Lai, Tianli
name: Huang, Zunnan
name: Luo, Lianxiang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Abnormal expression of PRDX has been found to play a significant role in the growth of colorectal cancer and other types of tumors. Despite the identification of several PRDX1 inhibitory compounds in recent years, none of them have been utilized in clinical treatments. Therefore, we conducted a virtual screening of 210,331 small molecules from the SPECS library using PRDX1 and multiple methods. From this screening, we identified 13 compounds with the highest scores from the molecular docking analysis. To further validate the accuracy of our pharmacophore model, we constructed a structure-based pharmacophore model and analyzed the receiver operating characteristic curve (ROC curve). Through this process, we selected nine compounds using skeleton jumping and virtual screening based on the highest pharmacophore model scores. Subsequently, we examined the ADMET properties of these nine compounds to assess their drug-forming potential, resulting in three compounds with the best drug properties. Finally, we assessed the binding stability of these three candidate molecules to proteins using molecular dynamics and MM-PBSA calculations. After a comprehensive evaluation, we found that compounds 6 and 9 formed stable complexes with PRDX1 proteins and could potentially serve as competitive inhibitors of PRDX1 substrates.
Seeing the random forest through the decision trees. Supporting learning health systems from histopathology with machine learning models: Challenges and opportunities
Creators: name: Gonzalez, Ricardo
name: Saha, Ashirbani
name: Campbell, Clinton J. V.
name: Nejat, Peyman
name: Lokker, Cynthia
name: Norgan, Andrew P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: This paper discusses some overlooked challenges faced when working with machine learning models for histopathology and presents a novel opportunity to support "Learning Health Systems" with them. Initially, the authors elaborate on these challenges after separating them according to their mitigation strategies: those that need innovative approaches, time, or future technological capabilities and those that require a conceptual reappraisal from a critical perspective. Then, a novel opportunity to support "Learning Health Systems" by integrating hidden information extracted by ML models from digitalized histopathology slides with other healthcare big data is presented.
Biological activity of new flavonoids and phenolic compounds from Cirsium italicum (Savi) DC.
Creators: name: Sabudak, Temine
name: Caliskan, Hilmican
name: Orak, H. Hulya
name: Ozer, Merve
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: Plant Biology

description: Cirsium italicum (Savi) DC. was researched for its phytochemicals for the first time. Two new biflavonoids, 5,5'',7''-trihydroxy-3,7-dimethoxy-4'-4'''-O-biflavone (3), (8,3',4',5'-tetrahydroxy-7-O-α-glucosyl isoflavone)-6-8''-(4'''-hydroxy-7''-O-α-glucosyl isoflavone) biflavone (7), a new isoflavone, 6-2'-dihydroxy-5-methoxy isoflavonone-4'-O-α-D-glucopyranoside (5) and a new phenolic compound, ethyl-(2,3-dihydroxy-5,6-dimethoxy-4-acetyl) benzoate (4), together with three known compounds (1), (2) and (6) were isolated from Cirsium italicum. Their structures were elucidated by extensive 1D and 2D NMR, and MS data analyses. All compounds isolated from C. italicum exhibited antioxidant activity. However, the highest activity of the EtOAc extract is considered to be responsible for compounds (1), (2) and (3) being the main compounds.
Two-way multi-lane traffic model for pedestrians in corridors
Creators: name: Appert-Rolland, Cécile
name: Degond, Pierre
name: Motsch, Sébastien
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: We extend the Aw-Rascle macroscopic model of car traffic into a two-way multi-lane model of pedestrian traffic. Within this model, we propose a technique for the handling of the congestion constraint, i.e. the fact that the pedestrian density cannot exceed a maximal density corresponding to contact between pedestrians. In a first step, we propose a singularly perturbed pressure relation which models the fact that the pedestrian velocity is considerably reduced, if not blocked, at congestion. In a second step, we carry over the singular limit into the model and show that abrupt transitions between compressible flow (in the uncongested regions) to incompressible flow (in congested regions) occur. We also investigate the hyperbolicity of the two-way models and show that they can lose their hyperbolicity in some cases. We study a diffusive correction of these models and discuss the characteristic time and length scales of the instability.
Gauged WZW Models Via Equivariant Cohomology
Creators: name: Garcia-Compean, Hugo
name: Paniagua, Pablo
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences
subject: 55N91

description: The problem of computing systematically the gauge invariant extension of WZW term through equivariant cohomology is addressed. The analysis done by Witten in the two-dimensional case is extended to the four-dimensional ones. While Cartan's model is used to find the anomaly cancelation condition. It is shown that the Weil model is more appropriated to find the gauge invariant extension of the WZW term. In the process we point out that Weil's and Cartan's models are also useful to stress some connections with the abelian anomaly.
description: 10 pages, no figures
MPEC 2023-X145 : 2023 XD4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 XD4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Antiproton modulation in the Heliosphere and AMS-02 antiproton over proton ratio prediction
Creators: name: Bobik, P.
name: Boschini, M. J.
name: Consolandi, C.
name: Della Torre, S.
name: Gervasi, M.
name: Grandi, D.
name: Kudela, K.
name: Pensotti, S.
name: Rancoita, P. G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We implemented a quasi time-dependent 2D stochastic model of solar modulation describing the transport of cosmic rays (CR) in the heliosphere. Our code can modulate the Local Interstellar Spectrum (LIS) of a generic charged particle (light cosmic ions and electrons), calculating the spectrum at 1AU. Several measurements of CR antiparticles have been performed. Here we focused our attention on the CR antiproton component and the antiproton over proton ratio. We show that our model, using the same heliospheric parameters for both particles, fit the observed anti-p/p ratio. We show a good agreement with BESS-97 and PAMELA data and make a prediction for the AMS-02 experiment.
In silico strategies for identifying therapeutic candidates against Acinetobacter baumannii: spotlight on the UDP-N-acetylmuramoyl-L-alanine-D-glutamate:meso-diaminopimelate ligase (MurE)
Creators: name: Kumar, Ankit
name: Singh, Pratyaksha
name: Singh, Ekampreet
name: Jain, Monika
name: Muthukumaran, Jayaraman
name: Singh, Amit Kumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The opportunistic bacterium Acinetobacter baumannii, which belongs to ESKAPE group of pathogenic bacteria, is leading cause of infections associated with gram-negative bacteria. Acinetobacter baumannii causes severe diseases, such as VAP (ventilator-associated pneumonia), meningitis, and UTI (urinary tract infections) among the nosocomial infections contracted in hospitals. The high infection rate and growing resistance to the vast array of antibiotics makes it paramount to look for new therapeutic strategies against this pathogen. The most promising therapeutic targets are the proteins involved in the synthesis of peptidoglycan which is chief component of bacterial cell wall, MurE is one of those enzymes and is responsible for the addition of one unit of meso-diaminopimelic acid (meso-A2pm) to the nucleotide precursor, UDPMurNAc-L-Ala-D-Glu, and aids in the formation of crosslinker pentapeptide chain. The three-dimensional structure of MurE was modelled using homology modelling technique and then vHTS was performed using this model against Approved Drug Library on DrugRep server using AutoDock Vina. Out of 500 drug molecules, two were selected based on estimated binding affinity, interaction pattern, interacting residues, etc. The selected drug molecules are DB12887 (Tazemetostat) and DB13879 (Glecaprevir). Then, MD simulations were performed on native MurE and its complexes with ligands to examine their dynamical behaviour, stability, integrity, compactness, and folding properties. The protein-ligand complexes were then subjected to binding free energy calculations using the MM/PBSA-based binding free energy analysis and the values are −109.788 ± 8.03 and −152.753 ± 11.98 kcal for MurE-DB12887 and MurE-DB13879 complex, respectively. All the analysis performed on MD trajectories for the complexes of these ligands with protein provided plenty of dependable evidences to consider these molecules for inhibition of MurE enzyme from A. baumannii.
Bioprospection for antiplasmodial activity, and identification of bioactive metabolites of native plants species from the Mata Atlântica biome, Brazil
Creators: name: Gontijo, Douglas Costa
name: Paulo Viana Leite, João
name: Nascimento, Maria Fernanda Alves do
name: Brandão, Geraldo Célio
name: de Oliveira, Alaíde Braga
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: A total of 33 extracts of eleven different plants species from Mata Atlântica biome, Brazil, and different fractions of the bioactive extracts were evaluated against chloroquine-resistant Plasmodium falciparum W2 strain by PfLDH method and cytotoxicity to HepG2 cells by the MTT assay, and chemically characterized by LC-DAD-ESI-MS/MS analysis. The results allowed the identification of Alchornea glandulosa, Miconia latecrenata, and Psychotria suterella as the most active plant species. Different flavonoids and tannins in Alchornea glandulosa and Miconia latecrenata besides alkaloids in Psychotria suterella were identified. Bioguided fractionation of A. glandulosa and M. latecrenata leaves extracts led to fractions exhibiting high parasite growth inhibition. Seven known alkaloids were identified in the P. suterella extract, and of these, only 5-carboxystrictosidine had been assayed for antiplasmodial activity what points to this species as the most promising among the eleven one assayed.
New Interactive Solar Flare Modeling and Advanced Radio Diagnostics Tools
Creators: name: Fleishman, Gregory D.
name: Nita, Gelu M.
name: Gary, Dale E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The coming years will see routine use of solar data of unprecedented spatial and spectral resolution, time cadence, and completeness in the wavelength domain. To capitalize on the soon to be available radio facilities such as the expanded OVSA, SSRT and FASR, and the challenges they present in the visualization and synthesis of the multi-frequency datasets, we propose that realistic, sophisticated 3D active region and flare modeling is timely now and will be a forefront of coronal studies over the coming years. Here we summarize our 3D modeling efforts, aimed at forward fitting of imaging spectroscopy data, and describe currently available 3D modeling tools. We also discuss plans for future generalization of our modeling tools.
description: 4 pages; IAU Symposium # 274 "Advances in Plasma Astrophysics"; typo removed