Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.
Creators: name: Siew, Keith
name: Nestler, Kevin A
name: Nelson, Charlotte
name: D'Ambrosio, Viola
name: Zhong, Chutong
name: Li, Zhongwang
name: Grillo, Alessandra
name: Wan, Elizabeth R
name: Patel, Vaksha
name: Overbey, Eliah
name: Kim, JangKeun
name: Yun, Sanghee
name: Vaughan, Michael B
name: Cheshire, Chris
name: Cubitt, Laura
name: Broni-Tabi, Jessica
name: Al-Jaber, Maneera Yousef
name: Boyko, Valery
name: Meydan, Cem
name: Barker, Peter
name: Arif, Shehbeel
name: Afsari, Fatemeh
name: Allen, Noah
name: Al-Maadheed, Mohammed
name: Altinok, Selin
name: Bah, Nourdine
name: Border, Samuel
name: Brown, Amanda L
name: Burling, Keith
name: Cheng-Campbell, Margareth
name: Colón, Lorianna M
name: Degoricija, Lovorka
name: Figg, Nichola
name: Finch, Rebecca
name: Foox, Jonathan
name: Faridi, Pouya
name: French, Alison
name: Gebre, Samrawit
name: Gordon, Peter
name: Houerbi, Nadia
name: Kahrood, Hossein Valipour
name: Kiffer, Frederico C
name: Klosinska, Aleksandra S
name: Kubik, Angela
name: Lee, Han-Chung
name: Li, Yinghui
name: Lucarelli, Nicholas
name: Marullo, Anthony L
name: Matei, Irina
name: McCann, Colleen M
name: Mimar, Sayat
name: Naglah, Ahmed
name: Nicod, Jérôme
name: O'Shaughnessy, Kevin M
name: De Oliveira, Lorraine Christine
name: Oswalt, Leah
name: Patras, Laura Ioana
name: Polo, San-Huei Lai
name: Rodríguez-Lopez, María
name: Roufosse, Candice
name: Sadeghi-Alavijeh, Omid
name: Sanchez-Hodge, Rebekah
name: Paul, Anindya S
name: Schittenhelm, Ralf Bernd
name: Schweickart, Annalise
name: Scott, Ryan T
name: Sian, Terry Chin Choy Lim Kam
name: da Silveira, Willian A
name: Slawinski, Hubert
name: Snell, Daniel
name: Sosa, Julio
name: Saravia-Butler, Amanda M
name: Tabetah, Marshall
name: Tanuwidjaya, Erwin
name: Walker-Samuel, Simon
name: Yang, Xiaoping
name: Yasmin
name: Zhang, Haijian
name: Godovac-Zimmermann, Jasminka
name: Sarder, Pinaki
name: Sanders, Lauren M
name: Costes, Sylvain V
name: Campbell, Robert AA
name: Karouia, Fathi
name: Mohamed-Alis, Vidya
name: Rodriques, Samuel
name: Lynham, Steven
name: Steele, Joel Ricky
name: Baranzini, Sergio
name: Fazelinia, Hossein
name: Dai, Zhongquan
name: Uruno, Akira
name: Shiba, Dai
name: Yamamoto, Masayuki
name: Almeida, Eduardo AC
name: Blaber, Elizabeth
name: Schisler, Jonathan C
name: Eisch, Amelia J
name: Muratani, Masafumi
name: Zwart, Sara R
name: Smith, Scott M
name: Galazka, Jonathan M
name: Mason, Christopher E
name: Beheshti, Afshin
name: Walsh, Stephen B
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Tumour Biology
subject: Tumour Biology
classificationCode: Chemical Biology & High Throughput
subject: Chemical Biology &amp; High Throughput
classificationCode: Gene Expression
subject: Gene Expression
classificationCode: Genetics & Genomics
subject: Genetics &amp; Genomics
classificationCode: Computational & Systems Biology
subject: Computational &amp; Systems Biology
classificationCode: Genome Integrity & Repair
subject: Genome Integrity &amp; Repair
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Microfabrication & Bioengineering
subject: Microfabrication &amp; Bioengineering
classificationCode: Synthetic Biology
subject: Synthetic Biology
classificationCode: Imaging
subject: Imaging

description: Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts' increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.