cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Non-uniform-band digital filter banks: Design and performance analysis.
Creators: name: Zhang, Genzao.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Electronics and Electrical.

description: New design techniques of digital filter banks are presented in this thesis. The research has been focused on systematic design methods for computationally efficient filter banks with arbitrary center frequencies, which could be easily implemented and are useful in acoustic, speech signal processing, and communication systems. Frequency interpolation filter banks (FIFB) are first derived based on an adaptive filtering structure. FIFB banks show good frequency responses, interesting sensitivities and negligible parameter quantization effects and roundoff noise when they are implemented using modern DSP processors with fixed-point arithmetic. For maximally flat FIFB filter banks, the adjusted pole selection strategy by an optimization procedure is applied. Then, the resonator-based arbitrarily spaced center frequency filter banks (RFB) are proposed. They show better behaviour than general FIFB banks from the point of view of frequency responses and the implementation. In order to suppress the non-negligible sidelobes and further improve the passband performance of the non-uniform band filter banks, frequency domain windowing techniques are studied and linear programming is used to produce optimal windows for different banks. Thus the design methods of non-uniform band filter banks with windowing processing are presented and significant improvements are obtained on the filter bank performance. Finally, the FIFB filter bank techniques are successfully extended to the field of allpass and perfect reconstruction analysis/synthesis systems. This widens the application area of the FIFB filter banks. In an allpass system, a synthesis FIFB filter bank is derived based on a general analysis FIFB bank and the allpass requirement. In the perfect reconstruction system, multirate techniques are applied and the efficient general FIR synthesis filter bank and IIR FIFB filter bank are designed to construct the system.
Outtake: Political roadblocks to trans student policy and research salvaging
Creators: name: Mullen, Carol A
Publisher: name: F1000 Research Limited
Year: 2025

description: Abstract

Political angst has escalated around controversial K–12 topics. Trans rights are under attack and affirming policies overturned, with growing hostility to gender equity in the U.S. When about to launch a study on school board decisions about trans student policy, the researchers encountered roadblocks and had to change direction. Prevented from interviewing board members, they ended up analyzing recorded debates to unmask factors impacting policy issues. Politics impeded access to boards through interviews. This untold research story involved a forced pivot and reimagined plan. Sharing critical incidents can spark creative solutions for salvaging research on sensitive topics.
An Analysis of the Incised Mudstone Concretions Found at Watmough Bay Site (45SJ280), Lopez Island, San Juans, Washington
Creators: name: Croes, Dale R.
Publisher: name: Washington State University
Year: 2024
Subjects: Watmough Bay site
Lopez Island, Washington State
Native Americans
Archaeology
Cultural Anthropology

description: A 1968 paper on incised mudstone concretions found in the summer excavations of the Watmough Bay site on Lopez Island for undergraduates classes with Dr. Robert Greengo and Bill Holm, University of Washington: Incised mudstone concretions are limey claystones which the Natives of Lopez Island had incised line-designs on for some unknown purpose. These incised designs do show some patterns and therefore inferences can be suggested as to some of the content. These inferences are based on comparative studies between techniques found among present day Northwest Coast groups and between patterns found in local archaeological sites.
СТОРИТЕЛЛИНГ КАК СРЕДСТВО ПРОДВИЖЕНИЯ БРЕНДА В БИЗНЕСЕ
Creators: name: Курочкина Валентина Андреевна
Publisher: name: Медиасреда
Year: 2020
Subjects: сторителлинг
бренд
продвижение
визуальный контент

description: Важная часть бизнеса – постоянно привлекать к себе внимание. Но компании не так важно внимание аудитории, как прибыль от продажи товаров и услуг. Чтобы продать, бренд сперва должен привлечь внимание людей к продукту. Лучший для этого способ – сторителлинг или рассказывание историй. Таким образом, с помощью него компания привлекает свою аудиторию.
КОРПОРАТИВНЫЕ БЛОГИ КОМПАНИЙ НА ВИДЕОХОСТИНГЕ YOUTUBE: СЕМИОТИЧЕСКИЙ АНАЛИЗ
Creators: name: Меньжурова Аюна Бадмаевна
name: Намсараева Валентина Цыдендамбаевна
Publisher: name: Медиасреда
Year: 2020
Subjects: архетип
видеоконтент
визуальные коммуникации
SMM
аудит социальных медиа.

description: В публикации исследуется роль архетипов в формировании целостного и понятного образа компании в корпоративных блогах. Цвет является простейшей единицей семиотического анализа архетипа. Продуманная визуализация средств коммуникации в социальных медиа дает возможность преодолеть клиповость мышления современной аудитории и повысить эффективность коммуникации компании в Интернете
Morality by Analogy: Kantian Beauty and its Relationship to Ethical Cognition
Creators: name: Helzner, Ben
Publisher: name: Brandeis University
Year: 2023
Subjects: Immanuel
Kant
Immanuel Kant
Beauty
Aesthetic Ideas
Sublimity
Sublime
Symbolism
Symbol
beautiful
morality
morally good
reason
ideas of reason
moral education
guyer
symbols of morality
art
critique of the power of judgment
critique of judgment
Paul Guyer
critical philosophy
kantian
judgment
Aesthetics

description: In the Critique of the Power of Judgment, Immanuel Kant argues that the beautiful is the symbol of the morally good. This paper argues that this claim is valuable as a conceptual connection between aesthetics and morality due to its ability to account for our intuitions while also not falling into the various conceptual issues into which other ways of connecting the two subjects fall. In the first chapter, the paper argues that four central characteristics of beauty which Kant argues for can be grounded with minimal relation to Kant's overall system. In the second chapter, the paper expands upon the sparse discussion Kant gives of symbolism, for the neglected purpose of having a clearer sense of the original claim Kant makes. In the course of this chapter, the largely undetermined Kantian category of 'ideas of reason' is retooled with respect to the possibility of having notions that require a sense of agency in others and an aside on aesthetic ideas and their connection to art and symbolism is considered. In the third chapter, the paper gives a brief exploration of certain core characteristics of morality before arguing first that the beautiful is a symbol of the morally good and second that the beautiful is (in a strong sense) the primary symbol of the morally good. In the course of this argument, the paper considers the possibility of the sublime (as posited by Paul Guyer) and aesthetic ideas being alternative symbols of the morally good, but finds that each has a different relationship to the morally good. The third chapter ends with some thoughts about the implications of the beautiful being the symbol of the morally good for moral education, and these considerations carry over into the conclusion. The paper concludes with some comparisons between the proposed symbolic relationship between beauty and morality and other possible ways of connecting the two, as well as a final discussion about the value of a sense of the beautiful for our moral lives.
Also included are two appendices. The first discusses beauty with an eye towards Kant's systematic philosophy, while the second considers a possible radical implication of the paper's newly refined notion of ideas of reason and a certain quality of beauty --- subjective universality --- for the foundations of Kant's moral theory.
ТРАНСФОРМАЦИЯ ФОРМАТОВ НАТИВНОЙ РЕКЛАМЫ В УСЛОВИЯХ ТЕХНОЛОГИЧЕСКИХ ПЕРЕМЕН
Creators: name: Петренко Екатерина Андреевна
Publisher: name: Медиасреда
Year: 2020
Subjects: нативная реклама
нативные интеграции
интернет-маркетинг
контент-маркетинг.

description: В данной статье автор рассматривает, как изменилась подача и интеграция рекламного материала в условиях изменения информационной среды и сознания человека. Интернет-маркетинг и контент-маркетинг –инструменты для создания успешной нативной интеграции. Благодаря им на конкретных примерах автором была выявлена классификация эффективных рекламных форматов для практического применения на площадке корпоративного сайта
The neglected burden of tuberculosis disease among health workers: a decade-long cohort study in South Africa
Creators: name: O’Hara, Lyndsay M.
name: Yassi, Annalee
name: Zungu, Muzimkhulu
name: Malotle, Molebogeng
name: Bryce, Elizabeth
name: Barker, Stephen J.
name: Darwin, Lincoln
name: Mark FitzGerald, J.
Publisher: name: BioMed Central
Year: 2017

description: Background: Health workers (HWs) in resource-limited settings are at high-risk of exposure to tuberculosis (TB) at work. The aim of this study was to estimate the rate of TB disease among HWs in the Free State Province of South Africa between 2002 and 2012 and to compare demographic and clinical characteristics between HWs and the general population with TB. This study also explores the effect of occupational variables on risk of TB among HWs. Methods: Probabilistic record linkage was utilized to identify HWs who were also registered as TB patients. This historical prospective cohort study calculated incidence rate ratios (IRR) for TB disease among HWs in Free State from 2002 to 2012. Generalized linear mixed-effects regression was used to model the association between sex, race, facility type, occupation, duration of employment, and the rate of TB. Results: There were 2677 cases of TB diagnosed among HWs from 2002 to 2012 and 1280 cases were expected. The overall TB incidence rate in HWs during the study period was 1496·32 per 100,000 compared to an incidence rate of 719·37 per 100,000 in the general population during the same time period. IRR ranged from 1·14 in 2012 to 3·12 in 2005. HWs who were male, black, coloured and employed less than 20 years had higher risk of TB. Facility type and occupation were not associated with increased risk of TB when adjusted for other covariates. Conclusion: HWs in South Africa have higher rates of TB than the general population. Improved infection prevention and control measures are necessary in all high-burden TB healthcare settings.
Les écologes et leurs impacts environnementaux dans la région de la Haute-Napo-Équateur.
Creators: name: Périgny, Yanik.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Geography.

description: This thesis explores the problem of ecotourism's environmental impacts in the Ecuadorian Amazon. Precisely, we tackle the impacts caused by ecolodges on the physical environment of a region that has been greatly affected by tourism development: the upper Napo river. For thirty years, ecolodges have set up operations in the region. The older ones have adapted to the changes in the Ecuadorian Amazon's tourism industry; newer ones were specifically developed for the growing demand in exotic and alternative accommodations in the jungle. The environmental wave that is responsible for the evolution of ecotourism consolidated that demand. Whether old or new, ecolodges have impacts on their operational environments. These impacts can be felt during construction, maintenance and daily tourism operations. Therefore, to improve the environmental performance of ecolodges, some recommendations have been linked to the activities that cause impacts. However, in the Ecuadorian Amazon, ecotourism's environmental impacts are less important than those caused by colonization and the petroleum industry. Therefore, ecotourism represents a sustainable development option in the regional context.
Martial Civilization: Native Americans, Moros, & the Indian Fighting Army's Grander Purpose
Creators: name: Thompson, Conor
Publisher: name: Brandeis University
Year: 2026
Subjects: Indigeneity
Moro Province
Moros
U.S. Empire
U.S. in the Pacific World

description: This paper examines U.S. Army officers’ contributions to discourse on indigeneity between 1879 and 1891 in the American West, and the ways in which the concept informed their interactions with the Islamic Moro peoples during U.S. Major General Leonard Wood’s tenure as military governor of the Moro Province of the U.S.-Philippines. It argues that by maintaining military government in the Moro Province, Wood’s administration legitimated the notion that the Army was fit to conduct civilizing missions on behalf of the United States; a notion which was previously not accepted outside of the military community. By emphasizing their expertise in the nature and character of racially and religiously different peoples, officers solidified their credibility as the rightful tutors of America’s most “primitive” colonial wards. Furthermore, by extolling the necessity of settler colonialism in the region, and the danger of proximate indigenous people, the U.S. Army prolonged their martial government, and transformed the precedent of a militarized frontier into a trans-imperial constant. Through this paper I hope to establish a basis on which to center domestic concepts of indigeneity, and the military-political aspirations of U.S. Army officers in future explorations of U.S. imperialism in the Pacific world.
Journal of Applied Hermeneutics, 2016
Creators: name: Journal Of Applied Hermeneutics
Publisher: name: Journal of Applied Hermeneutics
Year: 2016

description: Guest Editorial. "The more intense the practice, the more intense the demons": A Few Hermeneutic Caveats
Neonatal Transport Nursing is an Interpretive Practice
Knowing People and Interpretive Practice
Invited Guest Editorial: Nursing as Interpretation
Intensive Care Unit Nursing: An Interpretable and Hermeneutic Practice
Compassion, Necessity, and the Pharmakon of the Health Humanities
The Symbolism of Evil in the Big Book of AA
Secrets in the Open: An Exercise in Interpretive Writing
The Case of the Disappearing/Appearing Slow Learner: An Interpretive Mystery. Part Five: Time to Kill Time
Synergistic Research in Medical Education: Some Philosophical Reflections
Editorial: Following Good Leads
Invited Guest Editorial: Quaint Memories of Puzzling Through Mysteries
The Case of the Disappearing/Appearing Slow Learner: An Interpretive Mystery. Part Four: Quaint Notions of Justice
Invited Guest Editorial: Just Saying: For H/heaven’s Sake… Here’s Hoping --- “All Hell Could Break Loose!”
The Case of the Disappearing/Appearing Slow Learner: An Interpretive Mystery. Part Three: All Hell Could Break Loose
Gadamer on the Event of Art, the Other, and a Gesture Toward a Gadamerian Approach to Free Jazz
Invited Guest Editorial. Lives Worthy of Life: The Everyday Resistance of Disabled People
The Case of the Disappearing/Appearing Slow Learner: An Interpretive Mystery. Part Two: Cells of Categorical Confinement
"There Will Not Always Be Teachers Like This": For G.B.M.
Guest Editorial: Preface to "A Strange and Earnest Client" Part One of the Case of the Disappearing/Appearing Slow Learner: An Interpretive Mystery
Right There, in the Midst of It: Impacts of the Therapeutic Relationship on Mental Health Nurses
The Case of the Disappearing/Appearing Slow Learner: An Interpretive Mystery. Part One: A Strange and Earnest Client
Encountering the Great Problems in the Street: Enacting Hermeneutic Philosophy as Research in Practice Disciplines
Identification of suitable genetic resources of barley with potential for stress tolerance and as functional foods
Creators: name: Derakhshani, Zaynab
Publisher: name: Swinburne
Year: 2024

description: This study categorizes some of Australian barley genotypes based on their salt stress tolerance. Then, the changes in the concentration of some biomolecules (including abscisic acid, vitamin E isomers, phenolics and glycine betaine) are studied in the leaves and seeds of barley genotypes. These biomolecules are involved in plants stress tolerance and also known for their positive health effects for human. According to the current study barley synthesizes some of these biomolecules to adapt better with stress conditions and increase its antioxidant capacity which varies in barley genotypes.
Miscellaneous Articles Written in U.S. Army Publications, 1971-1976
Creators: name: Croes, Dale R.
Publisher: name: Washington State University
Year: 1971
Subjects: Archaeology

description: While in US Army Basic and Advanced Infantry Training in Fall of 1970, Dale Croes began to explore his interest in Northwest Coast Anthropology. He was assigned to the 122nd Public Information Detachment and wrote newsletter articles for the Army newspaper reflecting history topics, and some archaeological investigations, from 1970 until Honorably Discharged in 1976. Samples of these articles are included here along with original photographs by the author.
title: High-Field Open versus Short-Bore Magnetic Resonance Imaging of the Spine
title: A Randomized Controlled Comparison of Image Quality
titleType: Subtitle
Creators: name: Enders, Judith
name: Rief, Matthias
name: Zimmermann, Elke
name: Asbach, Patrick
name: Diederichs, Gerd
name: Wetz, Christoph
name: Siebert, Eberhard
name: Wagner, Moritz
name: Hamm, Bernd
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2013
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The purpose of the present study was to compare the image quality of spinal magnetic resonance (MR) imaging performed on a high-field horizontal open versus a short-bore MR scanner in a randomized controlled study setup. Methods Altogether, 93 (80% women, mean age 53) consecutive patients underwent spine imaging after random assignement to a 1-T horizontal open MR scanner with a vertical magnetic field or a 1.5-T short-bore MR scanner. This patient subset was part of a larger cohort. Image quality was assessed by determining qualitative parameters, signal-to-noise (SNR) and contrast-to-noise ratios (CNR), and quantitative contour sharpness. Results The image quality parameters were higher for short-bore MR imaging. Regarding all sequences, the relative differences were 39% for the mean overall qualitative image quality, 53% for the mean SNR values, and 34–37% for the quantitative contour sharpness (P<0.0001). The CNR values were also higher for images obtained with the short-bore MR scanner. No sequence was of very poor (nondiagnostic) image quality. Scanning times were significantly longer for examinations performed on the open MR scanner (mean: 32±22 min versus 20±9 min; P<0.0001). Conclusions In this randomized controlled comparison of spinal MR imaging with an open versus a short-bore scanner, short-bore MR imaging revealed considerably higher image quality with shorter scanning times.
Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey
Creators: name: Westwell-Roper, Clara
name: Lubieniecka, Joanna M.
name: Brown, Kelly L.
name: Morishita, Kimberly
name: Mammen, Cherry
name: Wagner-Weiner, Linda
name: Yen, Eric
name: Li, Suzanne C.
name: O’Neil, Kathleen M.
name: Lapidus, Sivia K.
name: Brogan, Paul
name: Cimaz, Rolando
name: Cabral, David A.
Publisher: name: BioMed Central
Year: 2017

description: Background: Because pediatric antineutrophil cytoplasmic antibody-associated vasculitis is rare, management generally relies on adult data. We assessed treatment practices, uptake of existing clinical assessment tools, and interest in pediatric treatment protocols among rheumatologists caring for children with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Methods: A needs-assessment survey developed by an international working group of pediatric rheumatologists and two nephrologists was circulated internationally. Data were summarized with descriptive statistics. Pearson’s chi-square tests were used in inferential univariate analyses. Results: The 209 respondents from 36 countries had collectively seen ~1600 children with GPA/MPA; 144 had seen more than two in the preceding 5 years. Standardized and validated clinical assessment tools to score disease severity, activity, and damage were used by 59, 63, and 36%, respectively; barriers to use included lack of knowledge and limited perceived utility. Therapy varied significantly: use of rituximab rather than cyclophosphamide was more common among respondents from the USA (OR = 2.7 [1.3-5.5], p = 0.0190, n = 139), those with >5 years of independent practice experience (OR = 3.8 [1.3-12.5], p = 0.0279, n = 137), and those who had seen >10 children with GPA/MPA in their careers (OR = 4.39 [2.1-9.1], p = 0.0011, n = 133). Respondents who had treated >10 patients were also more likely to continue maintenance therapy for at least 24 months (OR = 3.0 [1.4-6.4], p = 0.0161, n = 127). Ninety six percent of respondents believed in a need for pediatric-specific treatment guidelines; 46% supported adaptation of adult guidelines while 69% favoured guidelines providing a limited range of treatment options to allow comparison of effectiveness through a registry. Conclusions: These data provide a rationale for developing pediatric-specific consensus treatment guidelines for GPA/MPA. While pediatric rheumatologist uptake of existing clinical tools has been limited, guideline uptake may be enhanced if outcomes of consensus-derived treatment options are evaluated within the framework of an international registry.
НАПРАВЛЕНИЯ РАБОТЫ СОВРЕМЕННОГО КОММУНИКАЦИОННОГО АГЕНТСТВА
Creators: name: Сузьмина Ника Сергеевна
Publisher: name: Медиасреда
Year: 2020
Subjects: коммуникационное агентство
коммуникационные услуги
медиапространство
таргетинг
контент-план
бриф
видеоролик бэкстэйдж
коммуникативное пространство.

description: Рассматриваются направления работы современного коммуникационного агентства и его роль в современном медиапространстве. Настоящая работа основана на результатах исследования деятельности креативного коммуникационного агентства г. Челябинска. В ходе исследования автором были проанализированы функции современных агентств, выявлены особенности коммуникационной стратегии и тенденций коммуникационного рынка, а также будущие направления развития рынка. Материалы статьи дополнены разными подходами к определению «медиапространство».
ОСОБЕННОСТИ ИНТЕРНЕТ-ПРОДВИЖЕНИЯ НА ПЛОЩАДКЕ INSTAGRAM
Creators: name: Финк Софья Александровна
Publisher: name: Медиасреда
Year: 2020
Subjects: продвижение
инстаграм
таргетированная реклама
контент.

description: Сегодня Instagram является не просто социальной сетью для демонстрации красивых изображений. Это площадка для продвижения личного бренда, продажи различных товаров и услуг, а также инструмент для создания и поддержания имиджа. В своей статье мы рассмотрели особенности «умной ленты», влияние лайков на аудиторию, важность визуальной части оформления аккаунта и формирование контента для продвижения в Instagram.
A comparative analysis of physiological responses at submaximal work loads between simulated task performances of cycling.
Creators: name: Kenny, Glen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Animal Physiology.

description: The purpose of this study was to evaluate the relationships between heart rate (HR), oxygen consumption (VO$\sb2$) and mechanical Peak crank torque (PCT) and Average crank torque (ACT$\sb{60}$) variables in response to submaximal exercise employing a cycling race ergometer (RE), treadmill cycling (TC) and cycling in the field (FC). The work intensities identified as sub LT, LT and supra LT were equated on the basis of HR. Voltage signals from the crank arm were recorded as FM signals for subsequent representation of peak crank force (PCT) and average crank torque (ACT$\sb{60}$). Field VO$\sb2$ measures were done by Douglas bag procedure while an open circuit method was used for all laboratory testing. Heart rates were recorded with a Polar Electro Sport Tester PE3000. The observed results of field cycling demonstrated that laboratory conditions would overestimate the oxygen consumption in the field while force measurements suggested that laboratory conditions would underestimate mechanical work expenditures in the field. These differences become reduced at work intensities approximating VO$\sb{\rm 2max}$. It was concluded that HR can not always be used as an indicator of work stress when attempting to equate similar work loads performed under different conditions. (Abstract shortened by UMI.)
МАРКЕТИНГОВЫЕ И ЖУРНАЛИСТСКИЕ СПОСОБЫ ПРИВЛЕЧЕНИЯ АУДИТОРИИ К САЙТАМ СМИ
Creators: name: Шаповалова Екатерина Владимировна
Publisher: name: Медиасреда
Year: 2020
Subjects: аудитория интернет-СМИ
увеличение трафика онлайн-СМИ
способы привлечения трафика.

description: Статья описывает подходы к изучению характеристик аудитории интернет-СМИ, от которых зависят способы увеличения трафика сайтов СМИ. Автор подробно останавливается на методах привлечения аудитории интернет-СМИ как из области маркетинговых коммуникаций, так и тех, которые зависят только от журналиста. Представлен анализ популярных средств привлечения внимания в заголовках онлайн-СМИ.
АНГЛОЯЗЫЧНЫЕ ИНФОРМАЦИОННЫЕ И РЕКЛАМНЫЕ ИНСТАГРАМ-ПОСТЫ В СОВРЕМЕННОЙ PR-КОММУНИКАЦИИ
Creators: name: Елена Александровна Юхмина
name: Надежда Валерьевна Обвинцева
Publisher: name: Медиасреда
Year: 2020
Subjects: рекламные посты
информационные посты
PR-коммуникация
коммуникативная установка
языковые средства

description: За последнее десятилетие развитие виртуальной рекламы достигло своего расцвета. В статье исследуются англоязычные информационные и рекламные инстаграм-посты в сопоставительном аспекте, анализируются языковые средства, используемые авторами постов для создания определенной коммуникативной установки и требуемого воздействия на пользователей сети. В заключении авторы выявляют схожие и отличительные черты указанных постов и их роль для целей PR-коммуникации
Move away from a car-dominated city looks radical but it’s a sensible plan for a liveable future
Creators: name: Dia, Hussein
Publisher: name: Swinburne
Year: 2024

description: More shared spaces, safer streets and fewer cars in the city are all part of a newly released ten-year plan by the City of Melbourne. This evening, Town Hall will consider the ambitious draft transport strategy that would boost pedestrian, cycling and tram access across the CBD’s Hoddle Grid.
Cross-Omics Comparison of Stress Responses in Mesothelial Cells Exposed to Heat- versus Filter-Sterilized Peritoneal Dialysis Fluids
Creators: name: Kratochwill, Klaus
name: Bender, Thorsten O.
name: Lichtenauer, Anton M.
name: Herzog, Rebecca
name: Tarantino, Silvia
name: Bialas, Katarzyna
name: Jörres, Achim
name: Aufricht, Christoph
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Recent research suggests that cytoprotective responses, such as expression of heat-shock proteins, might be inadequately induced in mesothelial cells by heat-sterilized peritoneal dialysis (PD) fluids. This study compares transcriptome data and multiple protein expression profiles for providing new insight into regulatory mechanisms. Two-dimensional difference gel electrophoresis (2D-DIGE) based proteomics and topic defined gene expression microarray-based transcriptomics techniques were used to evaluate stress responses in human omental peritoneal mesothelial cells in response to heat- or filter-sterilized PD fluids. Data from selected heat-shock proteins were validated by 2D western-blot analysis. Comparison of proteomics and transcriptomics data discriminated differentially regulated protein abundance into groups depending on correlating or noncorrelating transcripts. Inadequate abundance of several heat-shock proteins following exposure to heat-sterilized PD fluids is not reflected on the mRNA level indicating interference beyond transcriptional regulation. For the first time, this study describes evidence for posttranscriptional inadequacy of heat-shock protein expression by heat- sterilized PD fluids as a novel cytotoxic property. Cross-omics technologies introduce a novel way of understanding PDF bioincompatibility and searching for new interventions to reestablish adequate cytoprotective responses.
ОСВЕЩЕНИЕ ИЗБИРАТЕЛЬНОЙ КАМПАНИИ ГУБЕРНАТОРА ЧЕЛЯБИНСКОЙ ОБЛАСТИ 2019 ГОДА КАК ФАКТОР ФОРМИРОВАНИЯ ЛОКАЛЬНОЙ ИНФОРМАЦИОННОЙ КАРТИНЫ
Creators: name: Агапова Виктория Владимировна
Publisher: name: Медиасреда
Year: 2020
Subjects: локальная информационная картина
информационные фильтры
образ города
предвыборная кампания
региональные СМИ
выборы губернатора.

description: В статье рассматривается освещение избирательной кампании губернатора в средствах массовой информации как фактора, влияющего на формирование локальной информационной картины. Выявлены доминирующие темы в новостной повестке периода выборов и установлена их связь с голосованием. На основе исследования публикаций сделан вывод о том, что происходит нивелирование самих выборов с целью создать эффект беспрерывного и стабильного управления регионом.
МНЕНИЕ АУДИТОРИИ СОЦИАЛЬНОЙ СЕТИ КАК ИНДИКАТОР ПРЕДСТАВЛЕНИЙ О ТОЛЕРАНТНОСТИ (НА ПРИМЕРЕ РЕКОМЕНДАЦИЙ АЛГОРИТМА «ПРОМЕТЕЙ» ВКОНТАКТЕ)
Creators: name: Арсентьева Анастасия Дмитриевна
name: Морозова Анна Анатольевна
Publisher: name: Медиасреда
Year: 2020
Subjects: толерантность
аудитория
социологический опрос
социальная сеть
ВКонтакте
«Прометей».

description: В статье рассмотрен вопрос отношения аудитории к публикациям социальной сети ВКонтакте, затрагивающим социально-значимые темы, в частности касающиеся вопросов толерантности. Материал исследования – результаты социологического опроса пользователей указанной социальной сети (N=200). Выводы демонстрируют постепенный рост толерантности в российском обществе, но в то же время противоречивое отношение аудитории к различным социальным меньшинствам и проблемам.
СОВРЕМЕННЫЕ ТЕНДЕНЦИИ ИСПОЛЬЗОВАНИЯ СОЦИАЛЬНЫХ СЕТЕЙ В СТРУКТУРЕ МАССОВОЙ КОММУНИКАЦИИ И ЖУРНАЛИСТИКИ
Creators: name: Афанасьева Елена Викторовна
Publisher: name: Медиасреда
Year: 2020
Subjects: интернет
социальные сети
медиажурналистика
тенденции
массовые коммуникации.

description: В статье рассматриваются современные тенденции использования социальных сетей в структуре массовой коммуникации и журналистики. С одной стороны, социальные платформы активизировали борьбу с дезинформацией. С другой – именно потребители будут решать, каким СМИ стоит доверять.
Promoting Positive Aging through Financial Capacity: Partial Least Square Correlation Analyses using the Financial Capacity Inventory-Short Form in Cognitively Normal Older Adults
Creators: name: Gold, Bailey Carol
Publisher: name: Brandeis University
Year: 2023
Subjects: Aging
Cognitive Psychology
Mental Health

description: With the population aging rapidly, it is important we determine specific targets for intervention for preserving cognitive function with age. Financial capacity is one possible target, as it is an essential skill required for maintaining autonomy in late life (Nowrangi et al., 2019); however, it is not clear how financial capacity relates to overall cognitive ability, mental status, and general well-being in cognitively normal older adults. In this study, we applied the Financial Capacity Inventory Short-Form (FCI-sf) to investigate older adults’ financial capabilities, assessed cognitive functioning using standard neuropsychological assessments, and examined mental health/lifestyle habits using self-report questionnaires (N= 119, age range = 59 – 92). Some participants also completed a grip strength test (N= 35). We conducted three partial least square correlation analyses (PLSC) to 1) examine the associations between financial capacity and cognitive performance, 2) study how financial capacity relates to various lifestyle factors, and 3) analyze the relationship between financial capacity and grip strength. These analyses isolated three latent variables that optimally express the multivariate association between participants’ financial capacity and cognitive performance (r = 0.50, p < 0.001), participants’ financial capacity and mental status/lifestyle (r = 0.46, p = 0.01), and participant’s financial capacity and grip strength (r = 0.55, p = 0.003). These findings indicate that better financial capacity ability is associated with greater neuropsychological performance/cognitive functioning, more positive mental health and healthier sleep habits, and better grip strength ability. This research is the first of its kind to suggest that the FCI-sf may be a tool that can be used for the appraisal of an older adult’s aging process based on multiple modalities and can detect subtle individual cognitive differences in cognitively normal older adults. 
EXPLORING THE MOLECULAR BASIS OF HP1-MEDIATED EPIGENETIC INHERITANCE
Creators: name: Ames, Amanda
Publisher: name: Brandeis University
Year: 2024

description: HP1 proteins are essential for establishing and maintaining transcriptionally silent heterochromatin. They dimerize, forming a binding interface to recruit diverse chromatin-associated factors. HP1 proteins are specialized and rapidly evolve, but the extent of variation required to achieve functional specialization is unknown. The fission yeast S. pombe has two HP1 homologs, Swi6 and Chp2, that have essential, nonredundant functions in heterochromatin regulation. Here, we investigate how changes in amino acid sequence impacts epigenetic inheritance by performing a targeted mutagenesis screen of the S. pombe HP1 homolog, Swi6. We identify substitutions within an auxiliary surface adjacent to the HP1 dimerization interface produce Swi6 variants with divergent maintenance properties. Remarkably, substitutions at a single amino acid position led to the persistent gain or loss of epigenetic inheritance. We find these substitutions increase Swi6 chromatin occupancy in vivo and altered Swi6-protein interactions that reprogram H3K9me maintenance. We present several biochemical approaches to characterize Swi6 and Chp2 biophysical properties in vitro. We observe differences in how these proteins bind to chromatin in vitro and in vivo. We show relatively minor changes in Swi6 amino acid composition can lead to profound changes in epigenetic inheritance which provides a redundant mechanism to evolve effector specificity. The findings in this work lay the groundwork for future studies in HP1 proteins and epigenetic inheritance.
title: Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer
title: A meta-analysis
titleType: Subtitle
Creators: name: Dong, Yue
name: Ochsenreither, Sebastian
name: Cai, Chengxuan
name: Kaufmann, Andreas M.
name: Albers, Andreas E.
name: Qian, Xu
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: There is a lack of predictive biomarkers that can identify patients with head and neck squamous cell carcinoma (HNSCC) who will experience treatment failure and develop drug resistance, recurrence, and metastases. Cancer stem-like cells (CSC) were identified as a subset of cells within the tumor in a variety of solid tumors including HNSCC. CSC are considered the tumor-initiating population responsible for recurrence or metastasis and are associated with therapy resistance. This meta-analysis including fourteen studies with altogether 1258 patients updates and summarizes all relevant data on the impact of ALDH1+ CSC on the prognosis of HNSCC and its association with clinicopathological parameters. ALDH1 expression is highly correlated with tumor differentiation (G3 vs. G1+G2; odds ratio = 2.85. 95% CI: 1.72–4.73, P<0.0001) and decreased overall survival (relative risk = 1.77. 95% CI: 1.41–2.22, P<0.0001) if one out of seven studies was excluded because of heterogeneity. These findings provide insights into the understanding of more aggressive tumor phenotypes and also suggest that the prognostic value provided by HNSCC-subtyping by CSC frequency warrant further clinical investigation.
Thromboembolic episodes related to atrial arrhythmias in adults with transposition of great arteries
Creators: name: Wan, Darryl
name: Tsui, Clara
name: Grewal, Jasmine
name: Kiess, Marla
name: Barlow, Amanda
name: Human, Derek
name: Krahn, Andrew
name: Chakrabarti, Santabhanu
Publisher: name: BioMed Central
Year: 2018

description: Background: Atrial arrhythmias (AA) are common in adults with congenital heart disease (ACHD). Although Intra-atrial Reentrant Tachycardia (IART) is well described in ACHD, Atrial Fibrillation (AF) is uncommon, but increasingly recognized. Patients with Transposition of the Great Arteries (TGA) and congenitally corrected-TGA (CC-TGA) have a high burden of AA at a relatively young age. However, long-term data of AA and associated thromboembolic risk are lacking in these patients. The prevalence, associated clinical factors, and complications of AA in a longitudinal TGA cohort was studied. Methods: A retrospective cohort study of all TGA patients from a single tertiary care centre was conducted. Data regarding documented atrial arrhythmias, thromboembolic events, and factors associated with thromboembolism were extracted and analyzed. Mean values and standard deviations were calculated for normally distributed continuous variables. When frequencies and means were compared, the chi-squared test and student t-test were used, respectively. Results: One-hundred twenty-five patients with TGA (76 TGA, 49 CC-TGA) were followed for a mean of 20.8 ± 13.2 years. AF was confirmed in 20% (n = 25) and there were 5 (20%) thromboembolic complications within the AF population. AF was associated with an annual thromboembolic event rate of 2.7%/year (stroke/transient ischemic attack 1.7%, systemic embolism 1.0%). Conclusion: AF is relatively common in the TGA ACHD population in long-term follow up. Although annual risk of thromboembolism is low in this young group of patients, life-time cumulative risk is potentially high. TGA patients should be screened actively for AF and appropriate anticoagulation therapy initiated. It is unclear if established risk prediction scores in other non-valvular AF populations may be applicable to this cohort.
Biochemical properties of the muscle-specific calcium(2+)/calmodulin-dependent protein kinase II beta isoform.
Creators: name: Chatzis, George J.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Pharmacology.

description: Cytosolic calcium (Ca2+) levels are critical for the control of muscle contraction and are tightly regulated by a variety of Ca 2+ transport systems localized in various membranes. Ca2+ binding proteins such as calmodulin (CaM) and Ca2+/CaM-dependent protein kinases (CaM Kinases) are believed to exert major regulatory control on Ca2+ activity. Previous studies in this lab led to the cloning of a cDNA encoding a CaM Kinase II beta isoform from skeletal muscle that differed from the classical beta isoform by the inclusion of three alternatively spliced exons in the variable domain which were enriched in proline residues. A CaM Kinase, assumed to be localized in the sarcoplasmic reticulum (SR), has been implicated in the regulation of excitation-contraction (E-C) coupling. We hypothesized that this novel CaM Kinase II beta isoform called SOCK (Son Of CaM Kinase) may be the CaM Kinase II isoform that regulates E-C coupling by being targeted to specific regions of the SR, whereby it phosphorylates critical Ca2+ transporting proteins such as the ryanodine (RyR) and dihydropyridine (DHPR) receptors in response to changes in Ca2+ levels. (Abstract shortened by UMI.)
Reviving Taiwan's bamboo manufactured products sectors: a case for design-led industry renewal
Creators: name: Lee, Hungwei
Publisher: name: Swinburne
Year: 2024

description: The thesis examines the decline of bamboo product manufacturing in regional Taiwan, which has been overwhelmed by competition from low-cost countries. In investigating how to help companies move beyond the Original Equipment Manufacturer sub-contractor business model to develop their own products, the thesis proposes a staged program based on the Danish Design Ladder and harnessing the collaborative effort of industry, government and university stakeholders.
Theoretical study of three problems related to the electrophoresis of polyelectrolytes.
Creators: name: Hubert, Sylvain.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Chemistry, Biochemistry.

description: Although mapping of human genes began early in the 20th century, about 99% of the genome is still unknown. Therefore, the development of new separation processes as well as a better understanding of the old separation techniques are needed to achieve the goals of this project. In 1994, P. Mayer, G. W. Slater and G. Drouin studied mathematically a new approach for the separation of DNA in free solutions where one attaches a neutral globular object at the end of the DNA molecule. This object would increase the friction and slow down the smaller DNA molecules more than the larger ones. In Chapter 2, we propose to attach a neutral flexible polymer instead. We demonstrate that this has the advantage of being more efficient as a friction generator. In 1994, A. E. Barron, H. W. Blanch and D. S. Soane obtained good DNA separations in ultra-dilute polymeric solutions. In Chapter 3, we develop the first theoretical model of this promising technology. This model is based on polymer hydrodynamics, molecular collisions and drag forces. In 1993, Zimm and Lumpkin proposed a new reptation model to explain gel electrophoresis of polyelectrolytes in irregular matrices. Following this work, we propose in Chapter 4 a more detailed model of this problem where the well-known memory effects of the standard reptation theory are taken into account. Our results are in qualitative agreement with available experimental results. (Abstract shortened by UMI.)
Network design and QoS provision in high-speed optical switching networks
Creators: name: Jin, Mushi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2007
Subjects: subject: Engineering, Electronics and Electrical.

description: Optical networking is a promising solution to support the ever-increasing Internet traffic. This thesis aims to investigate the important issues of topology design, resource sharing, differentiated service provision, flow control as well as the methodology for performance evaluation of optical networks. We first build two analytical models in order to approximate the loss rate of an Optical Burst Switching (OBS) node more accurately than the traditional burst-based methods. Through the analysis of interacting bursts at the core nodes, we compare the loss ratio of different flows under various assembly parameters. We then propose a DiffSery scheme by adjusting the assembly parameters for different optical bursts. This scheme is suitable for a distributed OBS network without any requirement on centralized information or operation. Next, we design a feedback-based OBS controller by assigning an exponential distribution to the burst assembly intervals. The loss rate of a flow can be controlled by adjusting the assembly timer. Based on this, we design and study a generic OBS controller for different assembly algorithms and signaling protocols that do not need global network information nor affect the network throughput. Some efficient predictor and adjuster models are proposed to implement the control process. Performance evaluation shows that this method is superior to other ordinary schemes based on the rate-adjustment method. Some critical issues on the system design and parameter settings are also investigated and discussed. Finally, we revisit the fundamental star topology to develop an overlaid-star topological variation and address various implementation issues in such architecture. We model the node connections as an asymmetrical multiconnection three-stage Clos network, and propose a network flow model to solve the routing, wavelength assignment and time slot assignment problems under the time-division-multiplexing operation. We demonstrate via simulations that this overlaid-star topology can support flexible QoS provisioning that we are currently studying. In summary, our work provides a technologically feasible solution to provide required QoS for future high-speed networks using available optical technologies.
Performance of direct sequence spread spectrum techniques for high rate communications in the high frequency band.
Creators: name: Drapeau, Michel.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Engineering, Electronics and Electrical.

description: For the last decade or so, major development in the fields of Large Scale Integration and Digital Signal Processing have revived the interest in the HF skywave channel (3-30 MHz) and more particularly in the use of wideband signalling to either increase the transmission rate or to improve the system efficiency. This thesis is aimed at the performance estimate of a wideband HF communication system using direct sequence spread spectrum. In this study, an HF channel model referred to as the Ionospheric Parameter Model is implemented in software and used to simulate a variety of channel conditions. BER performance for a communications systems transmitting at a rate of 2400 bits per second is estimated through 'Monte-Carlo' simulations. More specifically, direct sequence spread spectrum combined with a RAKE receiver implementation is evaluated under quiet and disturbed ionospheric conditions. Performance is compared for different processing gains and levels of multipath diversity. Finally, performance obtained with the addition of block coding and convolutional coding with and without interleaving is provided.