cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Nonoperative treatment for pain sensitization in patients with low back pain: protocol for a systematic review
Creators: name: Nopsopon, Tanawin
name: Suputtitada, Areerat
name: Lertparinyaphorn, Irin
name: Pongpirul, Krit
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Details of search strategies for each database.
Additional file 1 of Hematological malignancies in systemic lupus erythematosus: clinical characteristics, risk factors, and prognosis—a case-control study
Creators: name: Zhang, Yuqi
name: Li, Wei
name: Zhang, Panpan
name: Guo, Jinyan
name: Sun, Jinlei
name: Lu, Jiameng
name: Liu, Shengyun
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary Table 1. The lymphocyte subsets of SLE with/without hematological malignancies.
Подолання туберкульозу в Україні: Державна стратегія розвитку системи протитуберкульозної медичної допомоги населенню на 2020-2023 роки
Creators: name: Кабінет Міністрів України
name: Міністерство охорони здоров'я України
name: Харківський Регіональний Інститут Проблем Громадської Охорони Здоров'я
Publisher: name: Zenodo
Year: 2020
Subjects: туберкульоз
державна стратегія
епідеміологія
смертність
мережа протитуберкульозних закладів
трирівнева лабораторна мережа з діагностики туберкульозу
Україна
tuberculosis
state strategy
Ukraine
epidemiology
mortality
network of anti-tuberculosis institutions
three-level laboratory network for tuberculosis diagnostics

description: Українською: [Подолання туберкульозу в Україні: Державна стратегія розвитку системи протитуберкульозної медичної допомоги населенню на 2020-2023 роки. Вісник Харківського Регіонального Інституту Проблем Громадської Охорони Здоров'я (ISSN 2707-9287), 2020;93(1):4-13. https://doi.org/10.5281/zenodo.4010923] Ключові слова: туберкульоз, державна стратегія, Україна, епідеміологія, смертність, мережа протитуберкульозних закладів, трирівнева лабораторна мережа з діагностики туберкульозу. In English: [Overcoming tuberculosis in Ukraine: State strategy for the development of the system of anti-tuberculosis medical care for the population for 2020-2023. Bulletin of the Kharkiv Regional Institute of Public Health Services (ISSN 2707-9287), 2020;93(1):4-13. https://doi.org/10.5281/zenodo.4010923] Keywords: tuberculosis, state strategy, Ukraine, epidemiology, mortality, network of anti-tuberculosis institutions, three-level laboratory network for tuberculosis diagnostics.
Local Context Questionnaire sample for N3C IRB
Creators: name: N3C Consortium
name: Chute, Chris
Publisher: name: Zenodo
Year: 2020
Subjects: IRB
N3C

description: The National COVID Cohort Collaborative (N3C) opted to submit a single IRB at one of the organizing sites (Johns Hopkins University) to minimize the burden of participation for each site contributing clinical data to the N3C Secure Data Enclave. The N3C community collaboratively contributed to the core protocol. However, respecting site autonomy, the central IRB was not required; each site could opt to submit the core protocol to their own local IRB. This document is a sample Local Context Questionnaire sample for Participating Sites contributing clinical data to the N3C. For more information about N3C visit covid.cd2h.org
Additional file 1 of Identification and functional validation of HLA-C as a potential gene involved in colorectal cancer in the Korean population
Creators: name: Lim, Eun Bi
name: Oh, Ho-Suk
name: Kim, Kang Chang
name: Kim, Moon-Ho
name: Kim, Young Jin
name: Kim, Bong Jo
name: Nho, Chu Won
name: Cho, Yoon Shin
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. Distribution of minor allele frequencies (MAFs) of genotyping of 794 subjects by Illumina HumanExome BeadChip. Fig. S2. The expression levels of three CRC candidate genes such as SMCO1 (A), HLA-C (B), and NUTM1 (C). Fig. S3. Full-length blots and gel of Fig. 4 (C). Fig. S4. RNA sequencing analysis pipeline. Fig. S5. Heatmap of differentially expressed genes between HLA-C overexpressing stable cells (Over-HLA) and SW480 cells. Fig. S6. The allele frequency of rs1130838 in CRC and control subjects.
Additional file 1 of Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM
Creators: name: Jiang, Bao
name: Zhang, Junfeng
name: Sun, Xiubin
name: Yang, Chunyan
name: Cheng, Guanghui
name: Xu, Mengru
name: Li, Siyuan
name: Wang, Lina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Additional file 1: Table S1. The baseline characteristics of mothers and their neonates for the first and second-trimester cohorts. Table S2. The detailed clinical information of the three GDM cases for microarray analysis.
Supplementary material - Proteinuria screening at antenatal care booking
Creators: name: Magee, Laura A.
name: Sumedha Sharma
name: Sevene, Esperança
name: Rahat Qureshi
name: Ashalata Mallapur
name: Salésio Macuacua
name: Shivaprasad Goudar
name: Mrutyunjaya Bellad
name: Olalekan O. Adetoro
name: Payne, Beth A.
name: Sotunsa, John
name: Anifa Valá
name: Bone, Jeffrey
name: Shennan, Andrew H.
name: Vidler, Marianne
name: Bhutta, Zulfiqar A.
name: Dadelszen, Peter Von
Publisher: name: figshare
Year: 2020
Subjects: subject: 111402 Obstetrics and Gynaecology
subject: FOS: Clinical medicine

description: Supplementary material for the article: "Assessing the need for proteinuria screening at first antenatal care contact in India, Pakistan, Mozambique and Nigeria - prospective population-level data"
Additional file 2 of Identification and functional validation of HLA-C as a potential gene involved in colorectal cancer in the Korean population
Creators: name: Lim, Eun Bi
name: Oh, Ho-Suk
name: Kim, Kang Chang
name: Kim, Moon-Ho
name: Kim, Young Jin
name: Kim, Bong Jo
name: Nho, Chu Won
name: Cho, Yoon Shin
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Table S1. Results of Fisher’s exact test for CRC case-control association analysis. A total of 2,068variants were nominally associated with CRC (P-value < 0.05). Table S2. The summary statistic of reads produced by RNA sequencing and reads mapped to genome using TopHat2 aligner. Table S3. Differentially expressed genes (DEG) between SW480 colorectal cells (SW1, SW2, and SW3) and HLA-C overexpressing stable cells (S1, S2, and S3). Table S4. Functional annotation of 248 DEGs that fulfilled the selection criteria of |log2FC| ≥ 2 and adjusted P -value < 0.001. Functional annotation was based on Gene Ontology (GO) and KEGG pathway analyses implemented in DAVID 6.7. Table S5. Allele frequency of rs1130838 in several ethnic groups. Table S6. Pair-wise LD (r2) between a variant on HLA-C(rs1130838) and each variant (rs3131043 and rs9271770)near HLA-C region reported in Law, P.J. et al. (Nat Commun10, 2154 (2019)). Table S7. The primer sequences for qRT-PCR for CRC candidate genes.
Rechtssicherheit und rechtliche Standards für digitale Forschungsdaten - was wir nach 10 Jahren (nicht) erreicht haben
Creators: name: Hartmann, Thomas
Publisher: name: Zenodo
Year: 2025

description: Grundsatzvortrag am 10.03.2025 mit acht Thesen zur Rechtsentwicklung im Forschungsdatenmanagement in den letzten ca. zehn Jahren im Rahmen der Lecture Series "DatenHorizonte" von FDM-SH Office und dem Ministerium für Allgemeine und Berufliche Bildung, Wissenschaft, Forschung und Kultur des Landes Schleswig-Holstein (MBWFK).
Arteriovenous fistulae for haemodialysis: the role of the flow field and three-dimensional geometry in the development of neointimal hyperplasia
Creators: name: Corbett, Richard Wolferstan
Publisher: name: Imperial College London
Year: 2017

description: Native arteriovenous fistulae (AVF) for haemodialysis are susceptible to early failure and non-maturation. This is believed to occur due to the formation of juxtaanastomotic neointimal hyperplasia. Local geometry and features of the flow field are implicated in the formation of vascular disease. However, little is known about the correlates that lead to the development of adverse pathology and clinical outcomes in AVF, in particular the role of three-dimensional (non-planar) geometry. In this thesis, a mechanistic hierarchy is proposed where geometry influences the local flow field, in turn leading to the development of neointimal hyperplasia and ultimately non-maturation. This concept is explored using a variety of approaches: in vitro flow visualisation, an observational cohort study and a pre-clinical model. Flow visualisation work identifies the importance of vessel geometry, with an outer arterial curvature anastomosis appearing to suppress local flow instability as compared to straight or inner curvature. Using imaging on the day of surgery, an observational cohort study demonstrates significant geometric heterogeneity in surgically created AVF. Greater arterial curvature and non-planarity appear to be associated with improved rates of maturation. The association between the spectral estimates of the AVF bruit and outcome are also explored. Finally, placement of a prototype device derived from an idealised geometry suppresses flow instability, using changes in the bruit as a surrogate for the local flow field, though the effect on neointimal hyperplasia is less clear. Insights obtained from this work, with particular reference to arterial curvature and non-planarity, will provide the basis for future work designed to investigate the effect of idealised geometries on the development of vascular pathology and ultimately clinical trials aimed at improving outcomes associated with AVF surgery.
Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes
Creators: name: Prague, Julia Kate
Publisher: name: Imperial College London
Year: 2018

description: Seventy percent of menopausal women are affected by hot flushes and 10% describe them as intolerable. Symptoms are often highly disruptive, affecting all aspects of daily life, and persist for many years secondary to oestrogen deficiency. Hormone replacement therapy is effective but is not without risk, and alternative therapies that are currently available are not without side-effects and/or have variable efficacy. An effective novel therapy could therefore benefit 10 million women in the UK alone. Over the last 20 years, studies in animal and human models have implicated neurokinin B (NKB), a hypothalamic neuropeptide, together with its receptor (NK3R) in the aetiology of menopausal flushes. As such we hypothesised that an oral NK3R antagonist could attenuate menopausal flushes. This thesis outlines the data from our first in human, proof of concept, randomised, placebo controlled study to test the efficacy of an oral NK3R antagonist in attenuating menopausal flushes. Furthermore, it includes the data of subsequent mathematical modelling to investigate the association between luteinising hormone pulsatility and menopausal hot flushes, and basic science experiments to determine if genetic variation in the gene that encodes the neurokinin 3 receptor is important for experience of hot flushes and/or clinical response to an NK3R antagonist. The finding that pharmacological blockade of upregulated NKB/NK3R signalling with an oral NK3R antagonist significantly improves menopausal hot flush symptoms independent of any oestrogen effect suggests great promise for such agents as a novel therapeutic target to change future clinical practice. Larger scale studies of longer duration are the required next step in assessing the feasibility and likelihood of this.
Additional file 1 of Pathways involved in pony body size development
Creators: name: Fang, Jun
name: Zhang, Dong
name: Cao, Jun Wei
name: Zhang, Li
name: Liu, Chun Xia
name: Xing, Yan Ping
name: Wang, Feng
name: Xu, Hong Yang
name: Wang, Shi Chao
name: Ling, Yu
name: Wang, Wei
name: Zhang, Yan Ru
name: Zhou, Huan Min
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1:. Heights of the Debao pony and Mongolian horse at two developmental stages.
Using quality of life and frailty as predictors of recovery in cardiac surgery patients
Creators: name: Abdullahi, Yusuf
Publisher: name: Imperial College London
Year: 2018

description: Abstract Background: Frailty is a state characterised by a subclinical decline across multiple organ systems. High frailty is an independent predictor of poor outcome post cardiac surgery. The relationship between patient reported health related quality of life (HRQOL), their frailty status and the impact of cardiac surgeries to their quality of life and functional status has never been investigated in pre and post cardiac surgery. Objective. The objective of this study was to evaluate the relationship between frailty and QoL in pre-and post-cardiac surgery; the predictive value of frailty, pre-cardiac surgery symptoms, comorbidities, and their impact on QoL at four time points post-operatively. Method: The Reported Edmonton Frail Scale (REFS) was applied to all patients to evaluate their frailty score pre-operatively. The influence of frailty to baseline characteristics and quality of life at four time points was calculated. The QoL was assessed in both pre- and post-operatively. Generalised estimation equation (GEE) was applied to measure the influencing factors of quality of life at the four different time points. A wrist worn accelerometer was also applied to patients in order to objectively measure their physical activity levels in both pre-and post-operatively. Results: 105 patients (mean age of 77.22 ± 10.55 years) were successfully enrolled to the study of which 93 (88.57%) patients participated the follow-up period. High frail patients were twice more likely to have longer in-hospital stay than non-frail (Mean 21.2 vs. 9.6 days, p=0.016). The study proved baseline HRQOL has a direct relationship to post-operative HRQOL and survival. Frailty influenced in three out of the four activity levels. Postoperatively, high frail cohorts were more prone to higher complication rates compared to non-frail. Conclusion: The quality of life (QoL) of the vast majority of frail patients improved post cardiac surgery, few may appear to experience poor projection in QoL. Hence, it is inevitable to develop prediction models for recovery and expected improvement in QoL
title: Fotoalben im Jüdischen Museum Berlin
Creators: name: Ziehe, Theresia
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: Visual History
Year: 2024

description: Ein Schwerpunkt der Sammlung des Jüdischen Museums Berlin sind sogenannte Familienkonvolute, die starke biografische Bezüge aufweisen und dem Museum von Stifterinnen und Stiftern aus der ganzen Welt geschenkt wurden. Neben anderen Objekten umfassen diese Bestände viele Dokumente und zahlreiche Fotografien, darunter um die 400 Fotoalben.
Mise en évidence de stocks séparés d'Albacores (Thunnus albacares) dans l'Atlantique Tropical par l'étude des chiffres d'infestation parasitaire
Creators: name: Lardeux, Frederic
Publisher: name: Ecole Nationale Agronomique de Rennes
Year: 1980

description: Ce texte aborde l'étude des migrations et des stocks séparés de l’albacore (Thunnus albacares) dans l'Atlantique. Trois pêcheries exploitent cette espèce : la pêche à la palangre couvrant toute la zone de distribution, la pêche de surface à l'est (côtes africaines) et une petite pêcherie de surface à l'ouest. Les recherches actuelles visent à comprendre les migrations est-ouest dans l'Atlantique et nord-sud dans le golfe de Guinée, ainsi que les déplacements verticaux des thons, dans le but de gérer les stocks de manière plus efficace.

Pour identifier de potentiels stocks séparés, Baudin-Laurencin a proposé d'utiliser les parasites des albacores comme marqueurs biologiques, une approche innovante pour distinguer des poissons de zones géographiques distinctes. L'étude explore trois questions principales : peut-on identifier une répartition géographique générale des groupes d’albacores dans l’Atlantique ? Peut-on lier un poisson unique à une zone spécifique ? Et quelle est la viabilité de ce type d’étude ?

Le texte décrit la méthodologie, en insistant sur le matériel d'échantillonnage et les méthodes mathématiques spécifiques utilisées. Les résultats sont ensuite analysés, et des perspectives pour de futures recherches sont proposées.
Additional file 2 of Dynamic Tendon Grip (DTG™) novel knot array compared to traditional sutures for zone two flexor tendon injury – a biomechanical feasibility study
Creators: name: Kadar, Assaf
name: Fainzack, Alon
name: Vigler, Mordechai
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 2.
DIFFERENTIALS BETWEEN MEN COLLEGE KABADDI AND KHO-KHO PLAYERS ON SELECTED PHYSIOLOGICAL PARAMETERS
Creators: name: Siddanagouda R. Goudar* & Dr. P. Sivakumar**
Publisher: name: Zenodo
Year: 2023

description: The purpose of the study was to compare the resting pulse rate and breath holding time between men college kabaddi and kho-kho players.  To achieve this purpose of the study, sixty men players studying in the colleges in Karnataka state, India were selected as subjects at random.  Among them, thirty kabaddi players and thirty kho-kho players were selected. Among the physiological parameters, the following variables namely resting pulse rate and breath holding time were selected as criterion variables. 

All the subjects of two groups were tested on selected dependent variables by using radial pulse and holding the breath for time respectively. The independent ‘t’ ratio was used to analyze the significant difference, if any between groups.  The .05 level of confidence was fixed as the level of significance to test the obtained ‘t’ ratio, which was considered appropriate. The results of the study showed that there was a significant difference between kabaddi players and kho-kho players on resting pulse rate and breath holding time.
Analysis of linear and nonlinear dissipative systems
Creators: name: Won, Yong Sul
Publisher: name: Imperial College London
Year: 2018

description: The thesis consists of two projects. In the first part, we develop well-posedness theories for infinite dimensional Markov semigroups associated with a non-degenerate interacting diffusion process. Particularly, we present a construction of infinite volume semigroups in a domain of unbounded mannifold with respect to the L 2 -norm without specifying a reference measure. Moreover, we obtain smoothing estimates on a countable product of smooth, compact manifolds. In the second part, we study nonlinear reaction-diffusion systems that model population dynamics undergoing Lotka-Volterra type competitions in a heterogeneous environment. We propose a regularisation strategy of the PDEs to avoid the possibilities of singularities, and prove the global existence of a very weak solution.
Magnetic resonance spectroscopy in hypoxic ischaemic encephalopathy
Creators: name: Lally, Peter James
Publisher: name: Imperial College London
Year: 2018

description: Hypoxic-ischaemic encephalopathy results from an acute period of reduced oxygen (hypoxia) and blood flow (ischaemia) at the time of birth, and typically comes as the devastating end to an otherwise normal pregnancy. The most severely affected infants will die within days, whereas the majority who survive have a high chance of sustaining significant lifelong disabilities including cerebral palsy. This therefore has profound implications for the affected infant, their family, and wider society. Magnetic resonance spectroscopy allows the non-invasive investigation of cerebral metabolism, and provides quantitative measures of brain injury. Since hypoxic-ischaemic encephalopathy is associated with acute metabolic changes in the perinatal period, magnetic resonance spectroscopy has the potential to give insight into the ongoing injury, and potentially predict the neurodevelopmental prognosis of affected infants at an early stage. This thesis tests the hypothesis that magnetic resonance spectroscopy, acquired within two weeks of birth, is effective at predicting neurodevelopmental outcomes years after the initial hypoxic-ischaemic injury. This is achieved via a prospective multi-centre observational study across several institutions across the UK and USA, the results of which indicate exceptional prognostic value. The following work tests the hypothesis that accurate magnetic resonance spectroscopy measurements can be performed in the context of routine clinical settings to assist prognostication. A novel acquisition and analysis strategy is developed and validated, demonstrating precise and accurate results in a clinical setting within a modest acquisition time.
Additional file 1 of The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS
Creators: name: Kovacs, Mariángeles
name: Alamón, Catalina
name: Maciel, Cecilia
name: Varela, Valentina
name: Ibarburu, Sofía
name: Tarragó, Lucas
name: King, Peter H.
name: Si, Ying
name: Kwon, Yuri
name: Hermine, Olivier
name: Barbeito, Luis
name: Trias, Emiliano
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Supplementary Results with Figures 1–10 and Table 1.
Software
Creators: name: Vokey, John R
name: Thompson, Matthew B
name: Searston, Rachel A.
name: Tangen, Jason M
Publisher: name: OSF Registries
Year: 2018

description: This component contains the LiveCode script and source file (version 9.0.1) for generating the yoked sequences, as well as the LiveCode script and source file (version 9.0.1) for presenting the sequences and stimuli to participants and collecting their responses. LiveCode's Community Edition, is a free open source object-oriented, cross-platform, natural language rapid development environment that can be used for programming local (LiveCode) and web-based (HTML5) experiments in psychology. LiveCode is based on the Transcript programming language (a high-level xTalk scripting language like HyperCard's HyperTalk), and is a great stepping stone to learning Javascript and Python. It is fit for developing experiments that require fine-grained control, complex sequencing, and heavy back-end processing. You can download LiveCode for PC, Linux or Mac at: https://downloads.livecode.com/livecode/. You can run the current experiment on your own Mac OS by installing the appropriate version of LiveCode Community, downloading "runExperiment.zip" and opening the file "Scramble-Experiment01-SequencePresentationScript-RachelASearston.livecode." The "runExperiment" folder can be stored anywhere on your machine but the file structure within this folder needs to be preserved to run the experiment, as the script is reading in the participant sequences, images, and instructions on the fly. The experiment should also run on PC, with modest changes to the script. Correspondence about the LiveCode scripts can be addressed to rachel.searston@gmail.com.
Therapeutic targeting of tumour metabolism in neuroblastoma
Creators: name: Sikka, Arti
Publisher: name: Imperial College London
Year: 2018

description: Neuroblastoma is the most common extracranial solid tumour in childhood. Prognosis in the high-risk cases remains poor, highlighting the need for novel therapies. Neuroblastomas are characterised by a fundamental downregulation of mitochondrial respiration and a high glycolytic rate. This is due to genomic aberrations such as MYCN gene amplification and loss of chromosomal regions encoding succinate dehydrogenase subunits. This phenotype causes an increased reliance on pH-regulatory proteins, monocarboxylate transporters (MCTs) 1–4 and carbonic anhydrases (CAs) to maintain metabolic homeostasis. Myc has been linked to MCT-1 and CAIX expression and thus it was hypothesised that neuroblastomas would be sensitive to inhibition of these proteins. AZD3965 is a Phase I clinical candidate for MCT-1 inhibition whereas indisulam is a widely known Phase II clinical candidate for CAIX inhibition. As expected, MCT-1 inhibition blocked glycolysis and caused growth inhibition in 2-dimensional (-D) neuroblastoma models. However, there was a rapid onset of metabolic adaptation and 3-D spheroids were resistant. This resistance was overcome by combining MCT-1 inhibition with metformin, a mitochondrial complex I inhibitor. However, other adaptive mechanisms were also identified in 2-D. In contrast, we present a novel finding that indisulam monotherapy is efficacious in neuroblastoma, in vitro and in vivo. Notably, indisulam did not decrease the glycolytic rate as expected of a CAIX inhibitor. Instead, indisulam decreased cellular spare respiratory capacity and induced metabolic alterations associated with mitochondria. Consistent with a respiratory inhibitor, indisulam was also shown to synergise with MCT-1 inhibition, like metformin. In addition, indisulam recruited the RNA splicing factor and transcriptional coactivator, CAPERα, for proteasomal degradation and induced RNA splicing defects in neuroblastoma cells. Selective interference of CAPERα phenocopied the loss of respiratory capacity induced by indisulam. Thus, we propose that indisulam is a dual-inhibitor of mitochondrial metabolism and RNA splicing, serving as a novel therapeutic strategy in neuroblastoma.
Fine-grained deep-water turbidites, Baram Delta Province, Offshore Brunei Darussalam
Creators: name: Puasa, Idrus
Publisher: name: Imperial College London
Year: 2018

description: Thin-bedded turbidites dominate the deep-water succession of the Mio-Pliocene to Recent offshore Brunei Darussalam. This reflects the physical conditions conducive for the deposition of low-density turbidites by low energy sediment gravity flows. The focus of this study is to develop an understanding of these thin-bedded turbidites based on an integrated analysis utilising subsurface 3D seismic, well data, and surface outcrops through the application of both qualitative and quantitative approach. This study was conducted on the Miocene-Pliocene Baram Delta Province (BDP), focussing on the eastern slope of deep-water Brunei. From seismic data, the emphasis is on the origin of the high amplitude events deposited in the minibasins along the slopes. Quantitative interpretation from well data indicate (i) stacks of high amplitude events are interpreted to be caused by variations in lithology with relatively acoustically hard sand being modified by diagenetic process, encased by soft shale, and (ii) the apparent dominant thin-bedded turbidites deposited on the Brunei slopes reflects the efficient trapping of coarser sediments on the shelf behind the counter-regional growth fault. The sedimentology and environment of deposition of these thin-bedded turbidites are studied using a nearby Miocene outcrop succession. Detail analyses suggest the outcrop are: (a) low-density turbidites deposited by sustained, but overall decelerating flows with unidirectional palaeocurrent consistent with the palaeoslope of the Early Miocene, and (b) vertical stacking of sandstone beds reflect aggradational stacking of lobe elements in a lateral off-axis/fringe position. Quantification of bed thickness trends and vertical heterogeneity show: (1) outcrop data indicate statistically significant of thickening-upward (TkU), (2) limited applicability on the use of Hurst statistics to interpret depositional sub-environment, and (3) heterogeneity is governed by sampling protocol where increase in sampling frequency and decrease in sampling resolution, decreases heterogeneity.
Affiche Eslo2
Creators: name: Baude, Olivier
name: Dugua, Céline
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: Affiche de présentation du programme ESLO2 utilisée pour les opérations de communication externe vers un large public.
Additional file 3 of DIVIS: a semantic DIstance to improve the VISualisation of heterogeneous phenotypic datasets
Creators: name: Eid, Rayan
name: Landès, Claudine
name: Pernet, Alix
name: Benoît, Emmanuel
name: Santagostini, Pierre
name: Ghaziri, Angelina El
name: Bourbeillon, Julie
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 3 Silhouette analysis for the semantic distance. Silhouette values at the individual level for the KMeans algorithm, 2 to 19 clusters and the semantic distance.
Data and Results
Creators: name: Raea E. Rasmussen
name: Pagan, Jeremy
name: Hickey, Paige Connors
name: Eddine, Samer Nour
name: Urry, Heather L.
name: Garay, Maria
Publisher: name: OSF Registries
Year: 2020

description: In this component, we have uploaded our deidentified data, analysis code, and results.
Information-Theoretic Trust Regions for Stochastic Gradient-Based Optimization
Creators: name: Dahlinger, Philipp
name: Becker, Philipp
name: Maximilian, H.
name: Neumann, Gerhard
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2023

description: Stochastic gradient-based optimization is crucial to optimize neural networks. While popular approaches heuristically adapt the step size and direction by rescaling gradients, a more principled
approach to improve optimizers requires second-order information. Such methods precondition
the gradient using the objective’s Hessian. Yet, computing the Hessian is usually expensive and
effectively using second-order information in the stochastic gradient setting is non-trivial. We propose using Information-Theoretic Trust Region Optimization (arTuRO) for improved updates with
uncertain second-order information. By modeling the network parameters as a Gaussian distribution and using a Kullback-Leibler divergence-based trust region, our approach takes bounded steps
accounting for the objective’s curvature and uncertainty in the parameters. Before each update, it
solves the trust region problem for an optimal step size, resulting in a more stable and faster optimization process. We approximate the diagonal elements of the Hessian from stochastic gradients
using a simple recursive least squares approach, constructing a model of the expected Hessian over
time using only first-order information. We show that arTuRO combines the fast convergence of
adaptive moment-based optimization with the generalization capabilities of SGD.
Additional file 4 of DIVIS: a semantic DIstance to improve the VISualisation of heterogeneous phenotypic datasets
Creators: name: Eid, Rayan
name: Landès, Claudine
name: Pernet, Alix
name: Benoît, Emmanuel
name: Santagostini, Pierre
name: Ghaziri, Angelina El
name: Bourbeillon, Julie
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 4 Silhouette analysis for gower’s distance. Silhouette values at the individual level for the KMeans algorithm, 2 to 19 clusters and Gower’s distance.
title: A Methodology to Repair or Deorbit LEO Satellite Constellations
Creators: name: Gurgenburan, Goksol
Publisher: name: Old Dominion University Libraries
Year: 2011

description: n this thesis, mitigation of space debris is addressed by examining an approach for repair or de-orbit of a specific population of non-functional Low Earth Orbit (LEO) satellites. Basic orbital mechanics propagation of the orbits was used as the process for computing a solution to the time and intercept position for the targeted satellites. Optimal orbital maneuvers to reach the target satellites from a pre-established orbit were also considered. In this way minimum ΔV budget, rendezvous time and mass budgets were managed. The Clohessy-Wiltshire Equations and two-impulsive rendezvous maneuvers were used to determine the orbital path of a chase satellite between two position vectors, along with the time of flight. A monopropellant propulsion system was assumed in order to estimate propellant mass requirements. This methodology can be applied to a variety of satellite constellations, as implemented using MatLab and Analytical Graphics, Inc. STK software. Several cases were investigated in the study. Simulations showed that the methodology can provide guidance for the rendezvous process, facilitating a minimum ΔV budget and minimum rendezvous time.
Additional file 2 of Pathways involved in pony body size development
Creators: name: Fang, Jun
name: Zhang, Dong
name: Cao, Jun Wei
name: Zhang, Li
name: Liu, Chun Xia
name: Xing, Yan Ping
name: Wang, Feng
name: Xu, Hong Yang
name: Wang, Shi Chao
name: Ling, Yu
name: Wang, Wei
name: Zhang, Yan Ru
name: Zhou, Huan Min
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 2:. Sample correlation between tissues of Debao ponies and tissues of Mongolian horses.
title: Lettre à Laurent Guillemot et François Clavel (Institut Pasteur)
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111135799643
title: 01_1902
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1 of Living with a frozen shoulder – a phenomenological inquiry
Creators: name: Lyne, Suellen Anne
name: Goldblatt, Fiona Mary
name: Shanahan, Ernst Michael
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Additional file 1 of Efficiency of a deep learning-based artificial intelligence diagnostic system in spontaneous intracerebral hemorrhage volume measurement
Creators: name: Wang, Tao
name: Song, Na
name: Liu, Lingling
name: Zhu, Zichao
name: Chen, Bing
name: Yang, Wenjun
name: Chen, Zhiqiang
Publisher: name: figshare
Year: 2021
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1. Supplementary tables and figures.
Additional file 1 of Association between the type of thyroid dysfunction induced by immune checkpoint inhibitors and prognosis in cancer patients
Creators: name: Baek, Han-sang
name: Jeong, Chaiho
name: Shin, Kabsoo
name: Lee, Jaejun
name: Suh, Heysun
name: Lim, Dong-Jun
name: Kang, Moo Il
name: Ha, Jeonghoon
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 1: SupplementaryTable 1. Characteristics of thyrotoxicosis in patients.
Pedagogía y Psicología Comunitaria: Fronteras y Conexiones en Monsieur Lazhar, entre les Murs y la Ola
Creators: name: SAID-HUNG, ELIAS MANUEL
name: Piquer, Marc Pallarès
name: Hernández-Albarracín, Juan Diego
name: Planella, Jordi
Publisher: name: figshare
Year: 2020
Subjects: subject: Education
subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: 160809 Sociology of Education
subject: FOS: Sociology
subject: 130101 Continuing and Community Education
subject: FOS: Educational sciences

description: El artículo presenta una investigación sobre las relaciones entre el campo pedagógico y la psicología comunitaria. Se trata de dos campos disciplinares que históricamente han mantenido relaciones y se han cruzado en múltiples contextos, pero que cada una de ella se enmarca en epistemologías distintas. A partir del análisis de tres películas (Profesor Lazar, Entre les murs y La Ola) y desde la concepción del cine como creador de mundos y transcodificador de la sociedad, mostramos una cartografía de relaciones educativas no homogéneas. Concluimos que la relación de los sujetos con el mundo que les acoge es bicéfala, pedagógica y psicológica a la vez, no pudiendo prescindir de los elementos de orden formativo ni de la producción de subjetividad desde lo psico-comunitario.
Additional file 1 of The structural diversity of CACTA transposons in genomes of Chenopodium (Amaranthaceae, Caryophyllales) species: specific traits and comparison with the similar elements of angiosperms
Creators: name: Belyayev, Alexander
name: Josefiová, Jiřina
name: Jandová, Michaela
name: Kalendar, Ruslan
name: Mahelka, Václav
name: Mandák, Bohumil
name: Krak, Karol
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1 (1) Phylogenetic tree of the Chenopodium album agg. (2) Accessions and geographic origins of investigated Chenopodium album agg. species.
Additional file 3 of The structural diversity of CACTA transposons in genomes of Chenopodium (Amaranthaceae, Caryophyllales) species: specific traits and comparison with the similar elements of angiosperms
Creators: name: Belyayev, Alexander
name: Josefiová, Jiřina
name: Jandová, Michaela
name: Kalendar, Ruslan
name: Mahelka, Václav
name: Mandák, Bohumil
name: Krak, Karol
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3 Sequences of CACTA-like element Jozin from genomes of C. iljinii and C. vulvaria.
Influenza-Wochenbericht
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut
Year: 2020
Subjects: subject: AGI
subject: Influenza
subject: Wochenbericht
subject: 610 Medizin und Gesundheit

description: Die Aktivität der akuten Atemwegserkrankungen (ARE) ist in der 7. Kalenderwoche (KW) 2020 bundesweit relativ stabil geblieben, die Werte des Praxisindex lagen insgesamt im Bereich deutlich erhöhter ARE-Aktivität. Im Nationalen Referenzzentrum (NRZ) für Influenzaviren wurden in der 7. KW 2020 in 116 (63 %) von 183 Sentinelproben respiratorische Viren identifiziert, darunter 52 Proben mit Influenza A(H1N1)pdm09-, 25 Proben mit Influenza A(H3N2)- und sechs Proben mit Influenza B-Viren. Die Influenza-Positivenrate lag bei 45 % (95 %-Konfidenzintervall 37 bis 53 %). Für die 7. Meldewoche (MW) 2020 wurden nach Infektionsschutzgesetz (IfSG) bislang 19.273 labor-diagnostisch bestätigte Influenzafälle an das Robert Koch-Institut übermittelt (Datenstand: 18.2.2020). Die Influenza-Aktivität ist im Vergleich zur Vorwoche stabil geblieben.
Additional file 5 of The structural diversity of CACTA transposons in genomes of Chenopodium (Amaranthaceae, Caryophyllales) species: specific traits and comparison with the similar elements of angiosperms
Creators: name: Belyayev, Alexander
name: Josefiová, Jiřina
name: Jandová, Michaela
name: Kalendar, Ruslan
name: Mahelka, Václav
name: Mandák, Bohumil
name: Krak, Karol
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5. Pair wise distances between ORF 1 of the four Chenopodium on protein level.
Additional file 6 of The structural diversity of CACTA transposons in genomes of Chenopodium (Amaranthaceae, Caryophyllales) species: specific traits and comparison with the similar elements of angiosperms
Creators: name: Belyayev, Alexander
name: Josefiová, Jiřina
name: Jandová, Michaela
name: Kalendar, Ruslan
name: Mahelka, Václav
name: Mandák, Bohumil
name: Krak, Karol
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6 Comparative analysis of contigs and clones form Chenopodium iljinii genome.
The serum concentration and activity of DPP4 is positively related with the severity of hyperthyroidism in patients with Graves’ disease
Creators: name: Chang, Xiaona
name: Ding, Xiaoyu
name: Wang, Jiaxuan
name: Cai, Qingyun
name: Wang, Guang
name: Liu, Jia
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Graves’ disease (GD) is an organ-specific autoimmune disease. The production of anti-thyrotropin receptor antibodies (TRAb) is associated with a loss of immune tolerance. Dipeptidyl peptidase-4 (DPP-4) is expressed on multiple immune cells. This study aimed to investigate the relationship between serum concentration/activity of DPP4 and the severity of hyperthyroidism in GD patients. A total of 82 newly diagnosed drug-naive patients with GD hyperthyroidism, 20 patients with non-autoimmune thyrotoxicosis and 122 age- and sex- matched healthy controls were enrolled. The clinical parameters and serum concentration and activity of DPP4 were measured. The GD group had increased serum concentration and activity of DPP4 than the healthy controls and patients with non-autoimmune thyrotoxicosis, while no significant difference was observed in the latter two groups. Multivariate linear regression indicated that the serum concentration/activity of DPP4 were positively associated with FT3, FT4 and TRAb levels in the GD patients. And the positive association between serum concentration/activity of DPP4 and TRAb was remained even after adjustment for confounding factors (all p < 0.05). The GD patients had significantly increased serum concentration/activity of DPP4. And the serum concentration/activity of DPP4 was positively associated with the severity of hyperthyroidism in GD patients.Key messagesThe activity and concentration of DPP4 in patients with Graves’ disease were higher than those in healthy controls.There was a significant positive correlation between serum DPP4 concentration and TRAb levels in patients with Graves’ disease.In patients with Graves ‘disease, serum DPP4 activity was positively correlated with TRAb levels. The activity and concentration of DPP4 in patients with Graves’ disease were higher than those in healthy controls. There was a significant positive correlation between serum DPP4 concentration and TRAb levels in patients with Graves’ disease. In patients with Graves ‘disease, serum DPP4 activity was positively correlated with TRAb levels.
Self-esteem Importance Scale X Ambivalence X Certainty (Study 2)
Creators: name: Vaughan-Johnston, Thomas
name: Jacobson, Jill A.
Publisher: name: OSF Registries
Year: 2020
Subjects: ambivalence
certainty
importance
metacognition
self-esteem

description: Extending Study 1's results concerning certainty ratings of importance, into an analysis of ambivalence and certainty.
Additional file 7 of The structural diversity of CACTA transposons in genomes of Chenopodium (Amaranthaceae, Caryophyllales) species: specific traits and comparison with the similar elements of angiosperms
Creators: name: Belyayev, Alexander
name: Josefiová, Jiřina
name: Jandová, Michaela
name: Kalendar, Ruslan
name: Mahelka, Václav
name: Mandák, Bohumil
name: Krak, Karol
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 7. Primer pairs used in this study.