cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Next-to-next-to-leading order gravitational spin-orbit coupling via the effective field theory for spinning objects in the post-Newtonian scheme
Creators: name: Levi, Michèle
name: Steinhoff, Jan
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We implement the effective field theory for gravitating spinning objects in the post-Newtonian scheme at the next-to-next-to-leading order level to derive the gravitational spin-orbit interaction potential at the third and a half post-Newtonian order for rapidly rotating compact objects. From the next-to-next-to-leading order interaction potential, which we obtain here in a Lagrangian form for the first time, we derive straightforwardly the corresponding Hamiltonian. The spin-orbit sector constitutes the most elaborate spin dependent sector at each order, and accordingly we encounter a proliferation of the relevant Feynman diagrams, and a significant increase of the computational complexity. We present the evaluation of the interaction potential, going over contributing Feynman diagrams. The computation is carried out in terms of the nonrelativistic gravitational fields, together with the various gauge choices included in the effective field theory for gravitating spinning objects, which optimize the calculation. In addition, we automatize the effective field theory computations, and carry out the automated computations in parallel. Such automated effective field theory computations would be most useful to obtain higher order post-Newtonian corrections. We compare our Hamiltonian to the ADM Hamiltonian, and arrive at a complete agreement between the ADM and effective field theory results. We provide complete gauge invariant relations among the binding energy, angular momentum, and orbital frequency of an inspiralling binary with generic compact spinning components to third and a half post-Newtonian order. The derivation presented here is essential to obtain further higher order post-Newtonian corrections, and to reach the accuracy level required for the successful detection of gravitational radiation.
description: 38 pages, 6 figures; [v4] typos fixed eqs. (2.12),(2.34)
GENOSTOMA-KOZLOFFI SP-NOV AND G-INOPINATUM SP-NOV (TURBELLARIA, NEORHABDOCOELA, GENOSTOMATIDAE) FROM LEPTOSTRACAN CRUSTACENAS OF THE GENUS NEBALIA
Creators: name: Hyra, G. S.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1993

description: Two new species of the turbellarian genus Genostoma. living under the carapace of leptostracan crustaceans of the genus Nebalia, are described. Genostoma kozloffi is a symbiont of N. pugettensis in the San Juan Archipelago of Washington State ; G. inopinatum is associated with N. bipes at Roscoff on the Atlantic coast of France. The two species differ from one another, and also from G. tergestinum and G. marsiliense, both found on N. bipes at Mediterranean localities, in the shape of the body, relative pharynx size, and the structure of the reproductive system. The arrangement of the reproductive organs and sperm morphology in species of Genostoma suggest that Dorler (1900) and von Graff (1903) were correct in placing the genus in the order Rhabdocoela (now usually Neorhabdocoela), rather than in the Alloeocoela (now Prolecithophora) as proposed by Reisinger (1924). Reisinger's synomizing of Genostoma with Calandruccio's (1897) genus Hypotrichina is rejected, because these symbionts of Nebalia are decidedly different from the type species of Hypotrichina, which is a free-living member of the Otoplanidae (Prolecithophora).
CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells
Creators: name: Magness, Scott T.
name: Fuller, Megan K.
name: Dunn, James C.Y.
name: Martin, Martin G.
name: Wang, Fengchao
name: Stelzner, Matthias
name: Gracz, Adam D.
name: Li, Linheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Recent seminal studies have rapidly advanced the understanding of intestinal epithelial stem cell (IESC) biology in murine models. However, the lack of techniques suitable for isolation and subsequent downstream analysis of IESCs from human tissue has hindered the application of these findings toward the development of novel diagnostics and therapies with direct clinical relevance. This study demonstrates that the cluster of differentiation genes CD24 and CD44 are differentially expressed across LGR5 positive “active” stem cells as well as HOPX positive “facultative” stem cells. Fluorescence-activated cell sorting enables differential enrichment of LGR5 cells (CD24−/CD44+) and HOPX (CD24+/CD44+) cells for gene expression analysis and culture. These findings provide the fundamental methodology and basic cell surface signature necessary for isolating and studying intestinal stem cell populations in human physiology and disease.
title: Układ do zdalnego nadzoru stanu zasilania
Creators: name: Wojtasiewicz, Piotr
name: Jajczyk, Jarosław
name: Zielińska-Nawrowska, Maria
Publisher: name: Publishing House of Poznan University of Technology
Year: 2021

description: Poznan University of Technology Academic Journals. Electrical Engineering, 106, 113-124
Supplementary Information from Genetic coupling of signal and preference facilitates sexual isolation during rapid speciation.
Creators: name: Mingzi Xu
name: Shaw, Kerry L.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Supplementary methods, results, discussions, tables and figures
Powerful radiative jets in super-critical accretion disks around non-spinning black holes
Creators: name: Sadowski, Aleksander
name: Narayan, Ramesh
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We describe a set of simulations of super-critical accretion onto a non-rotating supermassive BH. The accretion flow is radiation pressure dominated and takes the form of a geometrically thick disk with twin low-density funnels around the rotation axis. For accretion rates $\gtrsim 10 \dot M_{\rm Edd}$, there is sufficient gas in the funnel to make this region optically thick. Radiation from the disk first flows into the funnel, after which it accelerates the optically thick funnel gas along the axis. The resulting jet is baryon-loaded and has a terminal density-weighted velocity $\approx 0.3c$. Much of the radiative luminosity is converted into kinetic energy by the time the escaping gas becomes optically thin. For an observer viewing down the axis, the isotropic equivalent luminosity of total energy is as much as $10^{48}\,\rm erg\,s^{-1}$ for a $10^7 M_\odot$ BH accreting at $10^3$ Eddington. Therefore, energetically, the simulated jets are consistent with observations of the most powerful tidal disruption events, e.g., Swift J1644. The jet velocity is, however, too low to match the Lorentz factor $γ> 2$ inferred in J1644. There is no such conflict in the case of other tidal disruption events. Since favorably oriented observers see isotropic equivalent luminosities that are highly super-Eddington, the simulated models can explain observations of ultra-luminous X-ray sources, at least in terms of luminosity and energetics, without requiring intermediate mass black holes. Finally, since the simulated jets are baryon-loaded and have mildly relativistic velocities, they match well the jets observed in SS433. The latter are, however, more collimated than the simulated jets. This suggests that, even if magnetic fields are not important for acceleration, they may perhaps still play a role in confining the jet.
description: 9 pages, 7 figures, submitted to MNRAS
Supplementary Information from Genetic coupling of signal and preference facilitates sexual isolation during rapid speciation
Creators: name: Mingzi Xu
name: Shaw, Kerry L.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60801 Animal Behaviour

description: Supplementary methods, results, discussions, tables and figures
Figure S1 and Tables S1 - S4 from Functional consequences of the long-term decline of reef-building corals in the Caribbean: evidence of across-reef functional convergence.
Creators: name: Estrada-Saldivar, Nuria
name: Jordan-Dalhgren, Eric
name: Rodriguez-Martinez, Rosa E.
name: Perry, Chris
name: Alvarez-Filip, Lorenzo
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Table S1: Classification of the coral species according to their form and contribution to the reef-structure.; Table S2: Mann-Whitney U-test values; Figure S1: Average coral cover for the studied sites for the back- and fore-reef zones. The error bars are the confidence intervals from the mean; Table S3: Coral cover on the surveyed sites (n = 16) with their respective reef-zone for each year.; Table S4: Mann-Whitney U-test values of the reef function parameters
Tracing planet-induced structures in circumstellar disks using molecular lines
Creators: name: Ober, F.
name: Wolf, S.
name: Uribe, A. L.
name: Klahr, H. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Circumstellar disks are considered to be the birthplace of planets. Specific structures like spiral arms, gaps, and cavities are characteristic indicators of planet-disk interaction. Investigating these structures can provide insights into the growth of protoplanets and the physical properties of the disk. We investigate the feasibility of using molecular lines to trace planet-induced structures in circumstellar disks. Based on 3D hydrodynamic simulations of planet-disk interactions, we perform self-consistent temperature calculations and produce N-LTE molecular line velocity-channel maps and spectra of these disks using our new N-LTE line radiative transfer code Mol3D. Subsequently, we simulate ALMA observations using the CASA simulator. We consider two nearly face-on inclinations, 5 disk masses, 7 disk radii, and 2 different typical pre-main-sequence host stars (T Tauri, Herbig Ae). We calculate up to 141 individual velocity-channel maps for five molecules/isotopoloques in a total of 32 rotational transitions to investigate the frequency dependence of the structures indicated above. We find that the majority of protoplanetary disks in our parameter space could be detected in the molecular lines considered. However, unlike the continuum case, gap detection is not straightforward in lines. For example, gaps are not seen in symmetric rings but are masked by the pattern caused by the global (Keplerian) velocity field. We identify specific regions in the velocity-channel maps that are characteristic of planet-induced structures. Simulations of high angular resolution molecular line observations demonstrate the potential of ALMA to provide complementary information about the planet-disk interaction as compared to continuum observations. In particular, the detection of planet-induced gaps is possible under certain conditions.(abridged)
description: 19 pages, 19 figures, accepted for publication in A&A
Concise review: Clinical programs of stem cell therapies for liver and pancreas: Stem Cell Therapies for Liver and Pancreas
Creators: name: Dominguez-Bendala, Juan
name: Inverardi, Luca
name: Gerber, David
name: Alvaro, Domenico
name: Cardinale, Vincenzo
name: Oikawa, Tsunekazu
name: Wang, Yunfang
name: Reid, Lola M.
name: Carpino, Guido
name: Furth, Mark E.
name: Cui, Cai-Bin
name: Gaudio, Eugenio
name: Gabriel, Mara
name: Lanzoni, Giacomo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Regenerative medicine is transitioning into clinical programs using stem/progenitor cell therapies for repair of damaged organs. We summarize those for liver and pancreas, organs that share endodermal stem cell populations, biliary tree stem cells (hBTSCs), located in peribiliary glands. They are precursors to hepatic stem/progenitors in canals of Hering and to committed progenitors in pancreatic duct glands. They give rise to maturational lineages along a radial axis within bile duct walls and a proximal-to-distal axis starting at the duodenum and ending with mature cells in the liver or pancreas. Clinical trials have been ongoing for years assessing effects of determined stem cells (fetal-liver-derived hepatic stem/progenitors) transplanted into the hepatic artery of patients with various liver diseases. Immunosuppression was not required. Control subjects, those given standard of care for a given condition, all died within a year or deteriorated in their liver functions. Subjects transplanted with 100-150 million hepatic stem/progenitor cells had improved liver functions and survival extending for several years. Full evaluations of safety and efficacy of transplants are still in progress. Determined stem cell therapies for diabetes using hBTSCs remain to be explored but are likely to occur following ongoing preclinical studies. In addition, mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) are being used for patients with chronic liver conditions or with diabetes. MSCs have demonstrated significant effects through paracrine signaling of trophic and immunomodulatory factors, and there is limited evidence for inefficient lineage restriction into mature parenchymal or islet cells. HSCs' effects are primarily via modulation of immune mechanisms.
Figure S1 and Tables S1 - S4 from Functional consequences of the long-term decline of reef-building corals in the Caribbean: evidence of across-reef functional convergence
Creators: name: Estrada-Saldivar, Nuria
name: Jordan-Dalhgren, Eric
name: Rodriguez-Martinez, Rosa E.
name: Perry, Chris
name: Alvarez-Filip, Lorenzo
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Table S1: Classification of the coral species according to their form and contribution to the reef-structure.; Table S2: Mann-Whitney U-test values; Figure S1: Average coral cover for the studied sites for the back- and fore-reef zones. The error bars are the confidence intervals from the mean; Table S3: Coral cover on the surveyed sites (n = 16) with their respective reef-zone for each year.; Table S4: Mann-Whitney U-test values of the reef function parameters
RELATIONSHIPS BETWEEN SIZE AND WEIGHT IN SOME COLONIAL CNIDARIA
Creators: name: Migne, A.
name: Davoult, D.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1993

description: Highly significant relationships between size and weight (p < 0,1 %) were determined in four colonial species : Alcyonium digitatum (W = 0.397 T1.987, N = 53, r = 0.945), Abietinaria abietina (W = 0.023 T1.716, N = 111, r = 0.960), Hydrallmania falcata (W = 0.048 T1.526, N = 87, r = 0.947) and Sertularia cupressina (W = 0.002 T2.315, N = 58, r = 0.958). The aim of this study is to estimate the production of colonial species by methods normally used for solitary species. To valid this process, biomass of the most abundant species, A. digitatum, was calculated by coupling the length histogram with the weight-length relationship and compared with real data. The difference between these two values (2.30 %) is very low.
Mechanically Activated Fyn Utilizes mTORC2 to Regulate RhoA and Adipogenesis in Mesenchymal Stem Cells
Creators: name: Case, Natasha
name: Uzer, Gunes
name: Xie, Zhihui
name: Yen, Sherwin S.
name: Brobst, Kaitlyn E.
name: Sen, Buer
name: Thompson, William R.
name: Styner, Maya
name: Guilluy, Christophe
name: Burridge, Keith
name: Rubin, Janet
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Mechanical strain provides an anti-adipogenic, pro-osteogenic stimulus to mesenchymal stem cells (MSC) through generating intracellular signals and via cytoskeletal restructuring. Recently, mTORC2 has been shown to be a novel mechanical target critical for the anti-adipogenic signal leading to preservation of β-catenin. As mechanical activation of mTORC2 requires focal adhesions (FAs), we asked whether proximal signaling involved Src and FAK, which are early responders to integrin-FA engagement. Application of mechanical strain to marrow-derived MSCs was unable to activate mTORC2 when Src family kinases were inhibited. Fyn, but not Src, was specifically required for mechanical activation of mTORC2 and was recruited to FAs after strain. Activation of mTORC2 was further diminished following FAK inhibition, and as FAK phosphorylation (Tyr-397) required Fyn activity, provided evidence of Fyn/FAK cooperativity. Inhibition of Fyn also prevented mechanical activation of RhoA as well as mechanically induced actin stress fiber formation. We thus asked whether RhoA activation by strain was dependent on mTORC2 downstream of Fyn. Inhibition of mTORC2 or its downstream substrate, Akt, both prevented mechanical RhoA activation, indicating that Fyn/FAK affects cytoskeletal structure via mTORC2. We then sought to ascertain whether this Fyn-initiated signal pathway modulated MSC lineage decisions. siRNA knockdown of Fyn, but not Src, led to rapid attainment of adipogenic phenotype with significant increases in adipocyte protein 2, peroxisome proliferator-activated receptor gamma, adiponectin, and perilipin. As such, Fyn expression in mdMSCs contributes to basal cytoskeletal architecture and, when associated with FAs, functions as a proximal mechanical effector for environmental signals that influence MSC lineage allocation.
title:  Controversie in materia di licenziamento e nuove forme di conciliazione
Creators: name: Dalfino, Domenico
Publisher: name: Roma TrE-Press
Year: 2016

description: Il saggio pone in evidenza le ragioni che impongono, o comunque rendono estremamente opportuno, un trattamento differenziato delle controversie relative al licenziamento rispetto a tutte le altre in materia di lavoro. In particolare, nel delineare i tratti essenziali della normativa in vigore con specifico riguardo agli strumenti di conciliazione, esso rimarca l’attuale tendenza del legislatore a “monetizzare” il posto di lavoro e l’arretramento delle tutele del lavoratore che ne consegue.
description: Scritti dedicati a Maurizio Converso
Dark matter and neutrino masses from a scale-invariant multi-Higgs portal
Creators: name: Karam, Alexandros
name: Tamvakis, Kyriakos
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider a classically scale invariant version of the Standard Model, extended by an extra dark $SU(2)_X$ gauge group. Apart from the dark gauge bosons and a dark scalar doublet which is coupled to the Standard Model Higgs through a portal coupling, we incorporate right-handed neutrinos and an additional real singlet scalar field. After symmetry breaking à la Coleman-Weinberg, we examine the multi-Higgs sector and impose theoretical and experimental constraints. In addition, by computing the dark matter relic abundance and the spin-independent scattering cross section off a nucleon we determine the viable dark matter mass range in accordance with present limits. The model can be tested in the near future by collider experiments and direct detection searches such as XENON 1T.
description: 28 pages, 9 figures. References added, typos fixed; matches version published in PRD
Next-to-next-to-leading order gravitational spin-squared potential via the effective field theory for spinning objects in the post-Newtonian scheme
Creators: name: Levi, Michèle
name: Steinhoff, Jan
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The next-to-next-to-leading order spin-squared interaction potential for generic compact binaries is derived for the first time via the effective field theory for gravitating spinning objects in the post-Newtonian scheme. The spin-squared sector is an intricate one, as it requires the consideration of the point particle action beyond minimal coupling, and mainly involves the spin-squared worldline couplings, which are quite complex, compared to the worldline couplings from the minimal coupling part of the action. This sector also involves the linear in spin couplings, as we go up in the nonlinearity of the interaction, and in the loop order. Hence, there is an excessive increase in the number of Feynman diagrams, of which more are higher loop ones. We provide all the Feynman diagrams and their values. The beneficial nonrelativistic gravitational fields are employed in the computation. This spin-squared correction, which enters at the fourth post-Newtonian order for rapidly rotating compact objects, completes the conservative sector up to the fourth post-Newtonian accuracy. The robustness of the effective field theory for gravitating spinning objects is shown here once again, as demonstrated in a recent series of papers by the authors, which obtained all spin dependent sectors, required up to the fourth post-Newtonian accuracy. The effective field theory of spinning objects allows to directly obtain the equations of motion, and the Hamiltonians, and these will be derived for the potential obtained here in a forthcoming paper.
description: 27 pages, 6 figures; [v4] typos fixed eqs. (2.18),(2.22)
The boundary quotient for algebraic dynamical systems
Creators: name: Brownlowe, Nathan
name: Stammeier, Nicolai
Publisher: name: arXiv
Year: 2015
Subjects: subject: Operator Algebras (math.OA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We introduce the notion of accurate foundation sets and the accurate refinement property for right LCM semigroups. For right LCM semigroups with this property, we derive a more explicit presentation of the boundary quotient. In the context of algebraic dynamical systems, we also analyse finiteness properties of foundation sets which lead us to a very concrete presentation. Based on Starling's recent work, we provide sharp conditions on certain algebraic dynamical systems for pure infiniteness and simplicity of their boundary quotient.
description: 23 pages
D4.6 Legal and Policy Framework and Federation Blueprint
Creators: name: Foggetti, Nadina
name: Gerin Laslier, Maryvonne
name: Di Giorgio, Sara
name: Haile Gebreyesus, Netsanet
name: Müller, Sabine
name: van Nieuwerburgh, Inge
name: Romier, Geneviève
name: Van Wezel, Jos
name: Hönegger, Lisa
name: Bodlos, Anita
name: Vernet, Marine
Publisher: name: Zenodo
Year: 2023
Subjects: EOSC
Open Science
Europe
Research

description: Development of EOSC is influenced by the parallel development at the national and regional levels. Requirements for open data, data protection and cross border data access rely on a common understanding of existing regulations procedures in countries and their differences. This deliverable presents the legal and organisational aspects of services delivery in a federated environment and recommends actions that enable service providers to position their services for improved interoperation in the context of the EOSC services landscape. The objectives of this deliverable are: a study of the legal and policy state of the art in the involved countries, highlighting commonalities to be leveraged and gaps or challenges to be tackled in order to help harmonise and improve the national policies and strategies related to FAIR data and Open Science, proposing recommendations for the rules and procedures with respect to legal issues regarding open access and open data, proposing policy recommendations for services management, focusing on the management of service level agreements, and delivering a blueprint for EOSC which can be used by service providers as a guideline for legal aspects of service and data provisioning in a European and an international context The document sketches a policy and legal framework by building upon the existing national policies, delivers recommendations, and considers the aspects that come with agreement on service delivery in a federated IT landscape. These can help to establish a governance structure for service providers and other organisations that handle scientific data. The checklist is also available as a separate, actionable, document: interactive digital version: https://doi.org/10.5281/zenodo.6327668 printable version: https://doi.org/10.5281/zenodo.6327691 The recommendations are also available as a separate digital document: https://doi.org/10.5281/zenodo.6451312
Food resources influencing the asexual reproductive cycle of coronate Scyphozoa
Creators: name: STAMPAR, Sérgio N.
name: SILVEIRA, Fábio Lang Da
name: MORANDINI, André C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2008

description: The study of the strobilation process, a feature unique in the class Scyphozoa, is an issue that helps understanding
 the patterns of asexual reproduction in sessile invertebrates. Many inducers of asexual reproduction are known for
 scyphozoans. However, the influence of food resources on the strobilation of Coronate Scyphozoa has never been tested.
 We observed strobilation of a large number of polyps of Nausithoe aurea, from a wide sampling area along the South
 Atlantic coast of Brazil, through the administration of controlled number of hatched nauplii of Artemia franciscana under
 a previous tested starvation and feeding protocol. The number of strobilations between and within groups varied and the
 fate and shape of strobilation deviated from the biology reported in the original description. Artificial seawater was used to
 reduce the influence of dissolved organic matter as likely important alternative nourishment.
Resumé : Influence de la ressource alimentaire sur le cycle de reproduction asexuée des Scyphozoa Coronata. L'étude de
 la strobilation dans la classe des Scyphozoa est importante pour comprendre les modes de reproduction asexuée chez les
 invertébrés sessiles inférieurs. De nombreux inducteurs de la reproduction asexuée des Scyphozoa sont connus. Toutefois,
 l'influence des ressources alimentaires sur la strobilation des Scyphozoa Coronata n'a jamais été testée. Nous avons
 observé la strobilation d'un grand nombre de polypes de Nausithoe aurea, provenant d'une vaste zone d'échantillonnage
 le long de la côte du Brésil len Atlantique Sud, en contrôlant l'apport du nombre de nauplii d'Artemia franciscana, dans le
 cadre d'un protocole déjà testé précédemment d'alimentation et de jeûne. Le nombre de strobilations entre et au sein des
 groupes a varié et le devenir et la forme de la strobilation a différé des données biologiques issues de la description origi-
 nale. L'eau de mer artificielle a été utilisée pour réduire l'influence de la matière organique dissoute comme importante
 source de nu
Tables S1 and S2 from Altered lentiviral infection dynamics follow genetic rescue of the Florida panther.
Creators: name: Malmberg, Jennifer L.
name: Lee, Justin S.
name: Gagne, Roderick B.
name: Kraberger, Simona
name: Kechejian, Sarah
name: Roelke, Melody
name: McBride, Roy
name: Onorato, Dave
name: Cunningham, Mark
name: Crooks, Kevin R.
name: VandeWoude, Sue
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60408 Genomics

description: Table S1: Host demographic information for all sequenced isolates. Ancestery dervied from Johnson et al. (12) (CFP, canonical Florida panther; BC, backcross; Adm, admixed; EVG, Everglades; AdmFP, admixed Florida panther; SEM, Seminole; TX, Texas; TBA, to be assigned).; Table S2: Primer names and sequences.
Protein Kinase Inhibitor γ Reciprocally Regulates Osteoblast and Adipocyte Differentiation by Downregulating Leukemia Inhibitory Factor: PKIγ Regulates Osteogenesis/Adipogenesis Via LIFs
Creators: name: Murakami, Shunichi
name: Greenfield, Edward M.
name: Chen, Xin
name: Rubin, Janet
name: Zhou, Guang
name: Hausman, Bryan S.
name: Luo, Guangbin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The Protein Kinase Inhibitor (Pki) gene family inactivates nuclear PKA and terminates PKA-induced gene expression. We previously showed that Pkig is the primary family member expressed in osteoblasts and that Pkig knockdown increases the effects of parathyroid hormone and isoproterenol on PKA activation, gene expression, and inhibition of apoptosis. Here, we determined whether endogenous levels of Pkig regulate osteoblast differentiation. Pkig is the primary family member in MEFs, murine marrow-derived mesenchymal stem cells, and human mesenchymal stem cells. Pkig deletion increased forskolin-dependent nuclear PKA activation and gene expression and Pkig deletion or knockdown increased osteoblast differentiation. PKA signaling is known to stimulate adipogenesis; however, adipogenesis and osteogenesis are often reciprocally regulated. We found that the reciprocal regulation predominates over the direct effects of PKA since adipogenesis was decreased by Pkig deletion or knockdown. Pkig deletion or knockdown simultaneously increased osteogenesis and decreased adipogenesis in mixed osteogenic/adipogenic medium. Pkig deletion increased PKA-induced expression of Leukemia Inhibitory Factor (Lif) mRNA and LIF protein. LIF neutralizing antibodies inhibited the effects on osteogenesis and adipogenesis of either Pkig deletion in MEFs or PKIγ knockdown in both murine and human mesenchymal stem cells. Collectively, our results show that endogenous levels of Pkig reciprocally regulate osteoblast and adipocyte differentiation and that this reciprocal regulation is mediated in part by LIF.
Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus: LINC Enables Sensing of Low-Intensity Vibrations
Creators: name: Rubin, Clinton T.
name: Sen, Buer
name: Xie, Zhihui
name: Miller, Sean
name: Judex, Stefan
name: Rubin, Janet
name: Yen, Sherwin S.
name: Bas, Guniz
name: Uzer, Gunes
name: Burridge, Keith
name: Thompson, William R.
name: Styner, Maya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A cell’s ability to recognize and adapt to the physical environment is central to its survival and function, but how mechanical cues are perceived and transduced into intracellular signals remains unclear. In mesenchymal stem cells (MSC), high magnitude substrate strain (HMS, ≥2%) effectively suppresses adipogenesis via induction of FAK/mTORC2/Akt signaling generated at focal adhesions [1]. Physiologic systems also rely on a persistent barrage of low level signals to regulate behavior [2]. Exposing MSC to extremely low magnitude mechanical signals (LMS) suppresses adipocyte formation [3] despite the virtual absence of substrate strain (<0.001%) [2], suggesting that LMS-induced dynamic accelerations can generate force within the cell. Here we show that MSC response to LMS is enabled through mechanical coupling between the cytoskeleton and the nucleus, in turn activating focal adhesion kinase (FAK) and Akt signaling followed by FAK-dependent induction of RhoA. While LMS and HMS synergistically regulated FAK activity at the focal adhesions, LMS-induced actin remodeling was concentrated at the perinuclear domain. Preventing nuclear-actin cytoskeleton mechanocoupling by disrupting LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes inhibited these LMS-induced signals as well as prevented LMS repression of adipogenic differentiation, highlighting that LINC connections are critical for sensing LMS. In contrast, FAK activation by high magnitude strain (HMS) was unaffected by LINC decoupling, consistent with signal initiation at the focal adhesion (FA) mechanosome. These results indicate that the MSC responds to its dynamic physical environment not only with “outside-in” signaling initiated by substrate strain, but vibratory signals enacted through the LINC complex enable matrix independent “inside-inside” signaling.
First record of parasitic copepod Peniculus fistula von Nordmann, 1832 (Siphonostomatoida: Pennellidae) from garfish Belone belone (Linnaeus, 1761) in the Adriatic Sea
Creators: name: VIDJAK, Olja
name: ZORICA, Barbara
name: SINOVCIC, Gorenka
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2008

description: During the investigation of garfish biology in the eastern Adriatic Sea in 2008, a number of fish infested with
 the pennellid copepod Peniculus fistula von Nordmann, 1832 was recorded. This is the first record of P. fistula in the
 Adriatic Sea and the first record of garfish as a host of this parasite. Morphological characteristics of P. fistula from the
 Adriatic Sea and some ecological parameters of this parasite-host association are presented.
Intranuclear Actin Regulates Osteogenesis: Intranuclear Actin Regulates Osteogenesis
Creators: name: Rubin, Janet
name: Xie, Zhihui
name: Styner, Maya
name: Wu, Xin
name: Thompson, William R.
name: Sen, Buer
name: Uzer, Gunes
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Depolymerization of the actin cytoskeleton induces nuclear trafficking of regulatory proteins and global effects on gene transcription. We here show that in mesenchymal stem cells (MSCs), cytochalasin D treatment causes rapid cofilin-/importin-9-dependent transfer of G-actin into the nucleus. The continued presence of intranuclear actin, which forms rod-like structures that stain with phalloidin, is associated with induction of robust expression of the osteogenic genes osterix and osteocalcin in a Runx2-dependent manner, and leads to acquisition of osteogenic phenotype. Adipogenic differentiation also occurs, but to a lesser degree. Intranuclear actin leads to nuclear export of Yes-associated protein (YAP); maintenance of nuclear YAP inhibits Runx2 initiation of osteogenesis. Injection of cytochalasin into the tibial marrow space of live mice results in abundant bone formation within the space of 1 week. In sum, increased intranuclear actin forces MSC into osteogenic lineage through controlling Runx2 activity; this process may be useful for clinical objectives of forming bone.
Electronic Supplementary File PDF from Krüppel-like factor/specificity protein transcription factor evolution in the spiralia and the implications for cephalopod visual system novelties
Creators: name: McCulloch, Kyle
name: Koenig, Kristen
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology

description: Supplementary Table 1 - 3 and Supplementary Figures 1 - 6
Tissue-Derived Stem and Progenitor Cells
Creators: name: Tesche, Leora J.
name: Gerber, David A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The characterization and isolation of various stem cell populations, from embryonic through tissue-derived stem cells, have led a rapid growth in the field of stem cell research. These research efforts have often been interrelated as to the markers that identify a select cell population are frequently analyzed to determine their expression in cells of distinct organs/tissues. In this review, we will expand the current state of research involving select tissue-derived stem cell populations including the liver, central nervous system, and cardiac tissues as examples of the success and challenges in this field of research. Lastly, the challenges of clinical therapies will be discussed as it applies to these unique cell populations.
Relaxation of curvature induced elastic stress by the Asaro-Tiller-Grinfeld instability
Creators: name: Köhler, C.
name: Backofen, R.
name: Voigt, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A two-dimensional crystal on the surface of a sphere experiences elastic stress due to the incompatibility of the crystal axes and the curvature. A common mechanism to relax elastic stress is the Asaro-Tiller-Grinfeld (ATG) instability. With a combined numerical and analytical approach we demonstrate, that also curvature induced stress in surface crystals can be relaxed by the long wave length ATG instability. The numerical results are obtained using a surface phase-field crystal (PFC) model, from which we determine the characteristic wave numbers of the ATG instability for various surface coverages corresponding to different curvature induced compressions. The results are compared with an analytic expression for the characteristic wave number, obtained from a continuum approach which accounts for hexagonal crystals and intrinsic PFC symmetries. We find our numerical results in accordance with the analytical predictions.
description: 6 pages, 5 figures
Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy
Creators: name: Caranasos, Thomas G.
name: Piedrahita, Jorge A.
name: Tang, Junnan
name: Hensley, M. Taylor
name: de Andrade, James Bizetto Meira
name: Vandergriff, Adam C.
name: Cheng, Ke
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Despite the efficacy of cardiac stem cells (CSCs) for treatment of cardiomyopathies, there are many limitations to stem cell therapies. CSC-derived exosomes (CSC-XOs) have been shown to be responsible for a large portion of the regenerative effects of CSCs. Using a mouse model of doxorubicin induced dilated cardiomyopathy, we study the effects of systemic delivery of human CSC-XOs in mice. Mice receiving CSC-XOs showed improved heart function via echocardiography, as well as decreased apoptosis and fibrosis. In spite of using immunocompetent mice and human CSC-XOs, mice showed no adverse immune reaction. The use of CSC-XOs holds promise for overcoming the limitations of stem cells and improving cardiac therapies.
Tables S1 and S2 from Altered lentiviral infection dynamics follow genetic rescue of the Florida panther
Creators: name: Malmberg, Jennifer L.
name: Lee, Justin S.
name: Gagne, Roderick B.
name: Kraberger, Simona
name: Kechejian, Sarah
name: Roelke, Melody
name: McBride, Roy
name: Onorato, Dave
name: Cunningham, Mark
name: Crooks, Kevin R.
name: VandeWoude, Sue
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60408 Genomics

description: Table S1: Host demographic information for all sequenced isolates. Ancestery dervied from Johnson et al. (12) (CFP, canonical Florida panther; BC, backcross; Adm, admixed; EVG, Everglades; AdmFP, admixed Florida panther; SEM, Seminole; TX, Texas; TBA, to be assigned).; Table S2: Primer names and sequences.
Magneto-Infrared Spectroscopic Study of Ultrathin Bi$_{2}$Te$_{3}$ Single Crystals
Creators: name: Tung, L. -C.
name: Yu, W.
name: Cadden-Zimansky, P.
name: Miotkowski, I.
name: Chen, Y. P.
name: Smirnov, D.
name: Jiang, Z.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Ultrathin Bi$_{2}$Te$_{3}$ single crystals laid on Scotch tape are investigated by Fourier transform infrared spectroscopy at $4$K and in a magnetic field up to $35$T. The magneto-transmittance spectra of the Bi$_{2}$% Te$_{3}$/tape composite are analyzed as a two-layer system and the optical conductivity of Bi$_{2}$Te$_{3}$ at different magnetic fields are extracted. We find that magnetic field modifies the optical conductivity in the following ways: (1) Field-induced transfer of the optical weight from the lower frequency regime ($<250$cm$^{-1}$) to the higher frequency regime ($% >250$cm$^{-1}$) due to the redistribution of charge carriers across the Fermi surface. (2) Evolving of a Fano-resonance-like spectral feature from an anti-resonance to a resonance with increasing magnetic field. Such behavior can be attributed to the electron-phonon interactions between the $% E_{u}^{1}$ optical phonon mode and the continuum of electronic transitions. (3) Cyclotron resonance resulting from the inter-valence band Landau level transitions, which can be described by the electrodynamics of massive Dirac holes.
Additional information regarding climate conditions at the field site (S1), field and lab methods (S2), and statistical analysis (S3) from Burrowing detritivores regulate nutrient cycling in a desert ecosystem.
Creators: name: Nevo Sagi
name: Grünzweig, José M.
name: Hawlena, Dror
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: (S1) Multiannual precipitation data, maximum and minimum daily temperatures, and wind speed data throughout the experimental period. (S2) Detailed description of the materials and methods used in the study - litter baskets experiment, soil sampling and lab microcosms. (S3) Detailed description of the statistical methods used in the study.
GENETICS OF SPHAEROMA-SERRATUM (F.) POPULATIONS .19. STUDY OF THE POPULATIONS OF THE BRITON COAST BETWEEN CANCALE AND SAINT-BRIEUC
Creators: name: Lejuez, R.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1993

description: The collection of Sphaeroma serratum natural populations along the part of Briton coast between Cancale and Saint-Brieuc enables to complete the map of distribution of major genes responsable for this Isopod polychromatism along the Channel and Atlantic coasts. 30 representative samples, including 40 046 individuals, were collected on this part of coast about 130 km long. Though the analysis of results corroborates the genetic complexity of Briton populations, it does not show any significative correlations in the distribution of frequencies in lunulatum distinctly more numerous than any where else, and in ornatum, on the one hand, and in signatum and ''red''. on the other hand.
Effect of Village Midwife Program on Contraceptive Prevalence and Method Choice in Indonesia
Creators: name: Wheeler, Stephanie B.
name: Thomas, Duncan
name: Paul, John E.
name: Weaver, Emily H.
name: Frankenberg, Elizabeth
name: Fried, Bruce J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Indonesia established its Village Midwife Program in 1989 to combat high rates of maternal mortality. The program’s goals were to address gaps in access to reproductive health care for rural women, increase access to and use of family planning services, and broaden the mix of available contraceptive methods. In this study, we use longitudinal data from the Indonesia Family Life Survey to examine the program’s effect on contraceptive practice. We find that the program did not affect overall contraceptive prevalence but did affect method choice. Over time, for women using contraceptives, midwives were associated with increased odds of injectable contraceptive use and decreased odds of oral contraceptive and implant use. Although the Indonesian government had hoped that the Village Midwife Program would channel women into using longer-lasting methods, the women’s “switching behavior” indicates that the program succeeded in providing additional outlets for and promoting the use of injectable contraceptives.
Direct evidence of predation in deep-sea nematodes: the case of Pontonema sp.
Creators: name: FONSECA, Gustavo
name: GALLUCCI, Fabiane
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2008

description: Shallow-water studies showed that adults of Oncholaimidae, including Pontonema, are facultative predators,
 while younger juveniles feed mainly on dissolved organic matter and decaying organisms. We examined the gut contents
 of 12 Pontonema specimens, four adults and eight juveniles, from the Arctic deep sea (1300-2500 m). An average of 4.25
 nematode preys per individual was found, together with spicules, organic matter and sediment. Particularly in three
 juveniles, 15, 13 and 10 preys, mainly juveniles of Thalassomonhystera, were found. These observations give evidence that
 feeding strategy within a genus may differ among environments and that previous laboratory experiments have under-
 estimated their predation rates.
SDSSJ14584479+3720215: A Benchmark JHK Blazar Light Curve from the 2MASS Calibration Scans
Creators: name: Davenport, James R. A.
name: Ruan, John J.
name: Becker, Andrew C.
name: Macleod, Chelsea L.
name: Cutri, Roc M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Active galactic nuclei (AGNs) are well-known to exhibit flux variability across a wide range of wavelength regimes, but the precise origin of the variability at different wavelengths remains unclear. To investigate the relatively unexplored near-IR variability of the most luminous AGNs, we conduct a search for variability using well sampled JHKs-band light curves from the 2MASS survey calibration fields. Our sample includes 27 known quasars with an average of 924 epochs of observation over three years, as well as one spectroscopically confirmed blazar (SDSSJ14584479+3720215) with 1972 epochs of data. This is the best-sampled NIR photometric blazar light curve to date, and it exhibits correlated, stochastic variability that we characterize with continuous auto-regressive moving average (CARMA) models. None of the other 26 known quasars had detectable variability in the 2MASS bands above the photometric uncertainty. A blind search of the 2MASS calibration field light curves for AGN candidates based on fitting CARMA(1,0) models (damped-random walk) uncovered only 7 candidates. All 7 were young stellar objects within the ρ Ophiuchus star forming region, five with previous X-ray detections. A significant γ-ray detection (5σ) for the known blazar using 4.5 years of Fermi photon data is also found. We suggest that strong NIR variability of blazars, such as seen for SDSSJ14584479+3720215, can be used as an efficient method of identifying previously-unidentified γ-ray blazars, with low contamination from other AGN.
description: 6 pages, 3 figures, ApJ Accepted
Giessener Universitätsblätter 1 (1968) Heft 1
Creators: name: (:Unkn) Unknown
name: Justus Liebig University Giessen
Publisher: name: Universitätsbibliothek Gießen
Year: 1968
Subjects: subject: ddc:000

description: Karl von Winckler: Grundprobleme der Bildunggspolitik. Hugo Freund: 50 Jahre Gießener Hochschulgesellschaft. Hans Werner Pia: Dem Gedächtnis von Ferdinand Wagenseil. Hans Linser: Das spezifisch Menschliche. Alfred Schraub, Jürgen Kiefer: Das Strahlenzentrum Gießen. Ulrich Mölk: Vom Detektivroman zum Nouveau roman.Versuch über Alain Robbe-Grillets "Les Gommes". Gerhard Wolf-Heidegger: Andreas Vesalius und seine Beziehungen zu Basel. Melchior Westhues: Wilhelm Pfeiffer und die Entwicklung der Veterinärmedizinischen Fakultät in Gießen.