cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ophiacanthidae Ljungman 1867
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Ophiacanthida
Ophiacanthidae

description: Ophiacanthidae
- oral GP with folded edge
- adGP bar-like, distally weakly inflated, with single condyle
- abGP kidney-shaped, thin, half as long as adGP
- RS without articular structures
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Core Concepts in Pharmacoepidemiology: New‐User Designs
Creators: name: Young, Jessica C.
name: Webster‐Clark, Michael
name: Her, Qoua L.
name: Tazare, John
name: Rouette, Julie
Publisher: name: Wiley
Year: 2024

description:
In this article, we review the history and key reasons for new-user comparisons in pharmacoepidemiology, highlighting the target trial framework as a unifying framework. We describe three distinct pharmacoepidemiological new-user study designs: (1) new-user versus non-user; (2) active comparator new-user; (i.e., ACNU) and (3) prevalent new-user (i.e., PNU) designs, and discuss how each relates to key issues of defining time zero, choosing appropriate comparator groups, and potential sources of bias they do and do not account for. We use a clinical example of hormone replacement therapy and the risk of coronary heart disease to illustrate practical considerations surrounding the application of the three designs presented.
Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers
Creators: name: Sumazin, Pavel
name: Heczey, Andras
name: Maris, John M.
name: Montalbano, Antonino
name: Courtney, Amy N.
name: Pogoriler, Jennifer
name: Thakkar, Sachin G.
name: Dotti, Gianpietro
name: Steffin, David
name: Lulla, Premal
name: Lapteva, Natalia
name: Lopez-Terrada, Dolores
name: Zhuyong, Mei
name: Ramos, Carlos A.
name: Brenner, Malcolm K.
name: Sweidan, Ramy
name: Gottschalk, Stephen
name: Zhang, Huimin
name: Ghatwai, Nisha
name: Varadarajan, Navin
name: Metelitsa, Leonid S.
name: Patel, Kalyani
name: Heslop, Helen E.
name: Arnett, Azlann B.
name: Masand, Prakash
name: Wang, Tao
name: Armaghany, Tannaz
name: Fleurence, Julien
name: Rathi, Purva
name: Grilley, Bambi J.
name: Martinez, Daniel
name: Lyon, Deborah
Publisher: name: Springer Nature
Year: 2024

description:
Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1–4. Glypican-3 (GPC3) is expressed in a group of solid cancers5–10, and here we report the evaluation in humans of the effects of IL-15 co-expression on GPC3-expressing CAR T cells (hereafter GPC3 CAR T cells). Cohort 1 patients (NCT02905188 and NCT02932956) received GPC3 CAR T cells, which were safe but produced no objective antitumour responses and reached peak expansion at 2 weeks. Cohort 2 patients (NCT05103631 and NCT04377932) received GPC3 CAR T cells that co-expressed IL-15 (15.CAR), which mediated significantly increased cell expansion and induced a disease control rate of 66% and antitumour response rate of 33%. Infusion of 15.CAR T cells was associated with increased incidence of cytokine release syndrome, which was controlled with IL-1/IL-6 blockade or rapidly ameliorated by activation of the inducible caspase 9 safety switch. Compared with non-responders, tumour-infiltrating 15.CAR T cells from responders showed repression of SWI/SNF epigenetic regulators and upregulation of FOS and JUN family members, as well as of genes related to type I interferon signalling. Collectively, these results demonstrate that IL-15 increases the expansion, intratumoural survival and antitumour activity of GPC3 CAR T cells in patients.
PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis.
Creators: name: He, Hongbin
name: Wang, Xiaomeng
name: Hou, Peili
name: Wang, Hongmei
name: Gao, Yan
name: Ren, Juan
name: Chang He, Daniel
name: He, Wenqi
name: Gao, Yuwei
name: Liu, Yu
name: Chu, Fengyun
name: Li, Min
name: Zhu, Hongchao
Publisher: name: Proceedings of the National Academy of Sciences
Year: 2024

description:
Phenazine biosynthesis-like domain-containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that the activity of PBLD extends to other PRRs, we focused on the RLR pathway activated via the p53-USP4-MAVS axis in response to virus infections. We found that PBLD deubiquitinates and stabilizes MAVS through ubiquitin-specific protease 4 (USP4) to promote antiviral innate immunity. Mechanistically, PBLD activates the transcription of USP4 via the upregulation of p53. USP4, which is a MAVS-interacting protein, substantially stabilizes the MAVS protein by deconjugating K48-linked ubiquitination chains from the MAVS protein at Lys461 during RNA virus infection. Most intriguingly, RNA virus-infected primary macrophages (peritoneal macrophages, PMs, and bone marrow-derived macrophages, BMDMs) and internal organ cells (lung and liver) from PBLD-deficient mice suppress the IFN-I response and promote viral replication. Notably, PBLD-deficient mice are more susceptible to RNA virus infection than their wild-type littermates. Our findings highlight a unique function of PBLD in antiviral innate immunity through the p53-USP4-MAVS signaling, providing a preliminary basis for research on PBLD as a target molecule for treating RNA virus infection.
BIG DATA VA IQTISODIY TADQIQOTLARDA TAHLILIY IMKONIYATLAR
Creators: name: Rajabova, Dilbar
name: Usmonova, Diyora
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqola Big Data texnologiyalarining iqtisodiy tadqiqotlardagi tahliliy imkoniyatlarini o‘rganishga qaratilgan.Zamonaviy iqtisodiyotda ma'lumotlarning roli  oshib bormoqda. Big Data (Katta Ma'lumotlar) tizimlari va texnologiyalarining rivojlanishi iqtisodiy tadqiqotlar va tahlil sohasida yangi imkoniyatlarni ochmoqda. Katta ma'lumotlar iqtisodiy jarayonlar, xususiyatlar va tendensiyalarni aniqlashda, shuningdek, prognozlash va qarorlar qabul qilishda samarali vosita sifatida ishlatiladi. Big Data atamasi hozirgi kunda zamonning talabi hisoblanadi. Big Data atamasi oldingi vaqtlarda ham ishlatilgan boʻlsada hozirgi kunda asosiy oqim vositasi hisoblanadi.Ushbu maqolada Big Data tizimi haqida toʻliq va chuqur maʼlumotlar berib oʻtilgan.Big Data tizimining oʻziga xos xususiyatlari ham yaxshi bahon etilgan. Mazkur tizim haqida toʻliq va sifatli qilib maʼlumotlar keltirilgan. Shuninhdek Big Data tizimidagi kamchiliklar va yutuqlar haqida ham koʻplab maʼlumotlar taqdim etilgan.
Additional file 5: of Implications of legal scrutiny processes (including the Lâ  Aquila trial and other recent court cases) for future volcanic risk governance
Creators: name: Bretton, Richard
name: Gottsmann, Joachim
name: Aspinall, Willy
name: Ryerson Christie
Publisher: name: Figshare
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Criminal Law offences and Regulation of geologists and geology.
Enhanced Biogas Production from Water Hyacinth and Cow Dung with Wood and Faecal Sludge Biochar
Creators: name: Ross, Andrew B.
name: Opio, Miria I.
name: Tumwesige, Vianney
name: Tumwesige, Rodney S.
name: Irumba, Collin
name: Kulabako, Robinah N.
name: Semiyaga, Swaib
name: Quintana-Najera, Jessica
name: Manga, Musa
Publisher: name: Elsevier
Year: 2024

description:
Water hyacinth (WH), known for its ecotoxicity and economic burden in tropical regions, can play an important role as a lignocellulosic biomass source for biogas production. Co-digesting WH with cow dung (CD) enhances biogas yield but poses challenges like process instability and excessive carbon dioxide production. To improve biogas yield from digestion of WH and CD, this study examined the impact of wood and faecal sludge biochar on the anaerobic co-digestion of CD and WH using a temperature of 37°C for 40 days. In the controlled laboratory tests, cow dung alone produced the least methane (CH4), but introducing 2% wood and faecal sludge biochars significantly boosted CH4 production by 76.8% and 94.0%, respectively. However, a 50% CD-50% WH mixture, the CH4 increase was milder at 20% and 37%, respectively. Wood biochar had no significant effect while faecal sludge biochar made a statistically significant impact (P < 0.05). These findings offer a sustainable solution, paving the way for cost-effective and eco-friendly biogas production in regions plagued by this invasive plant. The use of faecal sludge biochar, in particular, has substantial implications for optimizing anaerobic digestion processes and reducing their environmental footprint, thereby promoting a more sustainable approach to managing WH and addressing energy needs in tropical, eutrophic regions.
Ophiocamacidae O'Hara, Stohr, Hugall, Thuy & Martynov 2018
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Ophiacanthida
Ophiocamacidae

description: Ophiocamacidae
- oral GP strongly curved
- adGP bar-like, distally weakly inflated, with single condyle
- abGP blade-like flat
- RS with single condyle and groove
- madreporite inner side with central opening
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Additional file 3: of Red ceramics produced from mixtures of kaolinite clay and waste glass
Creators: name: Tiffo, Emmanuel
name: Elimbi, Antoine
name: Manga, Joseph
name: Tchamba, Arlin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S3. Mineralogical composition of the kaolinite clay K.
Thalassaphorura
Creators: name: Yan, Haijuan
name: Shi, Shidi
name: Chen, Jianxiu
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Onychiuridae
Thalassaphorura

description: Key to the Chinese species of the genus Thalassaphorura
1 Antennal base with 4 pseudocelli ....................................................................... tamurai
­ Antennal base with 3 pseudocelli.................................................................................. 2
2 Th. III with 1+1 pseudocelli ......................................................................... dinghuensis
­ Th. III with 3+3 pseudocelli.......................................................................................... 3
3 Ant. IV with sensory setae ..................................................................................... yodai
­ Ant. IV without sensory setae ....................................................................................... 4
4 Abd. V with 2+2 dorsal pseudocelli; ventral tube with 9+9 or 10+10 setae ... orientalis
­ Abd. V with 3+3 dorsal pseudocelli; ventral tube with 6+6 setae .... qixiaensis sp. nov.
description: Published as part of Yan, Haijuan, Shi, Shidi & Chen, Jianxiu, 2006, A new species of the genus Thalassaphorura from East China (Collembola: Onychiuridae), pp. 35-41 in Zootaxa 1369 on page 36, DOI: 10.5281/zenodo.174863
Additional file 3: of Robust optimization of SVM hyperparameters in the classification of bioactive compounds
Creators: name: Czarnecki, Wojciech
name: Podlewska, Sabina
name: Bojarski, Andrzej
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Analysis of the number of iterations of the optimization procedure required for reaching the highest accuracy for all tested targets. The file presents the number of iterations after which the optimal accuracy values were reached for all targets tested.
Ophiotomidae Paterson 1985
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Ophiacanthida
Ophiotomidae

description: Ophiotomidae
- oral GP with lobe
- adGP bar-like, distally widened, with two condylar processes
- abGP sickle-shaped
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Molecular Discovery of Filarial Nematode DNA in an Endangered Wild Pinniped (Galapagos Sea Lion, Zalophus wollebaeki)
Creators: name: Lewbart, Gregory A.
name: Vaden, Shelly L.
name: Hawkins, Eleanor C.
name: Gregory, Taylor M.
name: Breen, Matthew
name: Riofrío‐Lazo, Marjorie
name: Loyola, Andrea
name: Cave, Ashley
name: Páez‐Rosas, Diego
name: Deresienski, Diane
name: Livingston, Isabella G.
Publisher: name: Wiley
Year: 2024

description:
Rapidly changing environments are contributing to the spread of non-native species and their associated pathogens into new and vulnerable ecosystems, such as the Galapagos archipelago. These pathogens represent a significant threat to emblematic species. The Galapagos sea lion (Zalophus wollebaeki) (GSL) is an endangered and endemic pinniped that is increasingly at risk of acquiring infectious diseases due to interactions with introduced companion animals. Previously, we reported the first detection of antigens from Dirofilaria immitis, the parasite that causes canine heartworm disease, in the GSL. To investigate further, we developed a multifilarial PCR assay and successfully detected DNA from D. immitis and the closely related Dirofilaria repens in 10.7% of our sample cohort of juvenile GSLs. This assay, based on a conserved region in the filarial 28S gene, can be used in conjunction with restriction endonuclease digestion or Sanger sequencing to identify the species of the causative nematode. Our method proved effective without nonspecific amplification in a wide host range, and highly sensitive, detecting as little as one parasite. Further, this assay can be used in cases of immature, low-worm burden, or all-male infections. Our molecular approach offers a sensitive and specific method for detecting filarial parasites in wild animals. Further investigations are necessary to confirm the pathology of filarial nematodes in the GSL and their prevalence in the general population. Our identification of Dirofilarial species in the GSL underscores the urgent need for measures to manage the risk of pathogen transmission from introduced species to native wildlife.
Additional file 5: of Red ceramics produced from mixtures of kaolinite clay and waste glass
Creators: name: Tiffo, Emmanuel
name: Elimbi, Antoine
name: Manga, Joseph
name: Tchamba, Arlin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Table S5. Temperature changes on the dilatometry curves of KV0 and KV2.
Ophioleucida O'Hara, Hugall, Thuy, Stohr & Martynov 2017
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Ophioleucida

description: Ophioleucida
- central opening in inner madreporite
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society–USA Panel
Creators: name: Crabtree-Ramirez, Brenda E.
name: Jacobsen, Donna M.
name: Hoy, Jennifer F.
name: Buchbinder, Susan P.
name: Saag, Michael S.
name: Thompson, Melanie A.
name: Molina, Jean-Michel
name: Eron, Joseph J.
name: Lehmann, Clara
name: Eaton, Ellen F.
name: Landovitz, Raphael J.
name: Bedimo, Roger J.
name: del Rio, Carlos
name: Sax, Paul E.
name: Smith, Davey M.
name: Gandhi, Rajesh T.
name: Benson, Constance A.
name: Springer, Sandra A.
name: Günthard, Huldrych F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2025

description:
New data and new antiretroviral drugs and formulations continue to become available for the prevention and management of HIV infection. To provide updated recommendations for HIV treatment and clinical management and HIV prevention. A panel of volunteer expert physician scientists were appointed to provide updated consensus recommendations for 2024. Relevant evidence in the literature since the last report was identified from PubMed and Embase searches (which initially yielded 3998 unique citations, of which 249 were considered relevant); from ongoing monitoring of the literature by the panel members; from data submitted by product manufacturers; and from studies presented at peer-reviewed scientific conferences between June 2022 and October 2024. Antiretroviral therapy continues to be recommended for all individuals with HIV. For most people with HIV, initial regimens composed of an integrase strand transfer inhibitor (InSTI), specifically bictegravir or dolutegravir, with 2 (and in some cases 1) nucleoside or nucleotide reverse transcriptase inhibitors are recommended. Recommendations are made for those with particular clinical circumstances, such as pregnancy and active opportunistic diseases, as well as for those unable to take InSTIs. Regimens may need to be changed for virologic failure, adverse effects, convenience, or cost, among other reasons. Long-acting injectable therapy is available for those who prefer not to take daily oral medications and for people struggling with adherence to daily therapy. Recommendations are provided for laboratory monitoring, management of substance use disorders and weight changes, as well as use of statins for cardiovascular disease prevention. For HIV prevention, oral (daily or intermittent) and injectable long-acting medications are effective options for people at increased likelihood of HIV exposure. Further, new tools for maintaining health and well-being among people with HIV, such as doxycycline postexposure prophylaxis to avert sexually transmitted infection, and strategies to treat substance use disorders, are recommended. Disparities in HIV acquisition and care access are discussed and solutions proposed. New approaches for treating and preventing HIV offer additional tools to help end the HIV epidemic, but achieving this goal depends on addressing disparities and inequities in access to care.
Nonhuman primate models of pediatric viral diseases
Creators: name: Vijayan, K.K. Vidya
name: De Paris, Kristina
Publisher: name: Frontiers
Year: 2024

description:
Infectious diseases are the leading cause of death in infants and children under 5 years of age. In utero exposure to viruses can lead to spontaneous abortion, preterm birth, congenital abnormalities or other developmental defects, often resulting in lifelong health sequalae. The underlying biological mechanisms are difficult to study in humans due to ethical concerns and limited sample access. Nonhuman primates (NHP) are closely related to humans, and pregnancy and immune ontogeny in infants are very similar to humans. Therefore, NHP are a highly relevant model for understanding fetal and postnatal virus-host interactions and to define immune mechanisms associated with increased morbidity and mortality in infants. We will discuss NHP models of viruses causing congenital infections, respiratory diseases in early life, and HIV. Cytomegalovirus (CMV) remains the most common cause of congenital defects worldwide. Measles is a vaccine-preventable disease, yet measles cases are resurging. Zika is an example of an emerging arbovirus with devastating consequences for the developing fetus and the surviving infant. Among the respiratory viruses, we will discuss influenza and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We will finish with HIV as an example of a lifelong infection without a cure or vaccine. The review will highlight (i) the impact of viral infections on fetal and infant immune development, (ii) how differences in infant and adult immune responses to infection alter disease outcome, and emphasize the invaluable contribution of pediatric NHP infection models to the design of effective treatment and prevention strategies, including vaccines, for human infants.
Ophiernidae O'Hara, Stohr, Hugall, Thuy & Martynov 2018
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Ophioleucida
Ophiernidae

description: Ophiernidae
- adGP bar-like, distal triangular lateral process, single condyle, groove
- abGP flat blade-like, concave articular structure
- RS articular structure as minute spurs
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Bilateral waveform analysis of gait biomechanics presurgery to 12 months following ACL reconstruction compared to controls
Creators: name: Bjornsen, Elizabeth
name: Lisee, Caroline
name: Spang, Jeffrey
name: Pietrosimone, Brian
name: Kamath, Ganesh
name: Creighton, Alexander
name: Favoreto, Natália
name: Buck, Ashley
name: Blackburn, Troy
name: Büttner, Christin
name: Franz, Jason R.
Publisher: name: Wiley
Year: 2024

description:
The purpose of this study was to compare gait biomechanics between limbs and to matched uninjured controls (i.e., sex, age, and body mass index) preoperatively and at 2, 4, 6, and 12 months following primary unilateral anterior cruciate ligament reconstruction (ACLR). Functional mixed effects models were used to identify differences in gait biomechanics throughout the stance phase between the a) ACLR limb and uninvolved limb, b) ACLR limb and controls, and c) uninvolved limb and controls. Compared with the uninvolved limb, the ACLR limb demonstrated lesser knee extension moment (KEM; within 8-37% range of stance) during early stance as well as lesser knee flexion moment (KFM; 45-84%) and greater knee flexion angle (KFA; 43-90%) during mid- to late stance at all timepoints. Compared with controls, the ACLR limb demonstrated lesser vertical ground reaction force (vGRF; 5-26%), lesser KEM (7-47%), and lesser knee adduction moment (KAM; 12-35%) during early stance as well as greater vGRF (39-63%) and greater KFA (34-95%) during mid- to late stance at all timepoints. Compared with controls, the uninvolved limb demonstrated lesser KFA (1-56%) and lesser KEM (12-54%) during early to mid-stance at all timepoints. While gait becomes more symmetrical over the first 12 months post-ACLR, the ACLR and uninvolved limbs both demonstrate persistent aberrant gait biomechanics compared to controls. Biomechanical waveforms throughout stance can be generally described as less dynamic following ACL injury and ACLR compared with uninjured controls.
Additional file 2: of Robust optimization of SVM hyperparameters in the classification of bioactive compounds
Creators: name: Czarnecki, Wojciech
name: Podlewska, Sabina
name: Bojarski, Andrzej
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: AUC values obtained for all target/fingerprint pairs for curves illustrating changes in the accuracy with time and the optimal accuracy values obtained. The file contains the AUC and optimal accuracy values obtained in the experiments. The AUC values were calculated on the basis of curves illustrating changes in the accuracy values in time for different SVM optimization strategies.
Long-term outcomes of EUS-guided gastroenterostomy: a large, single center experience.
Creators: name: Kahlenberg, Sam
name: Trieu, Judy A
name: Hathorn, Kelly
name: Baron, Todd H
name: Gilman, Andrew J
Publisher: name: Wolters Kluwer
Year: 2024

description:
INTRODUCTION: EUS-guided gastroenterostomy (EUS-GE) is effective and safe in benign and malignant indications. However, there is a paucity of literature on the outcomes of these patients. Our study evaluates the long-term outcomes of patients who underwent EUS-GE and stent-related adverse events (AEs). METHODS: This retrospective study took place at a tertiary-care institution from January 1, 2014 to December 31, 2022. Patients who underwent EUS-GE were included. Procedure details and outcomes were recorded. Patients were followed for at least 3 months after the procedure. RESULTS: A total of 207 patients (50.3% male, mean age 62.3 years) underwent EUS-GE for malignant (N=117, 56.5%) and benign (N=90, 43.5%) indications. Overall technical success was 95.7%. Patients were followed for a mean of 406 days. Stents were removed in 25.6% of patients; common reasons include completed access for endoscopic retrograde cholangiopancreatography (ERCP) (N=13, 25%), resection/resolution of gastric outlet obstruction (GOO) (N=28, 53.8%), and surgical resection of malignant GOO (N=8, 15.4%). EUS-GE stents remained in place in 63.6% of patients for ≥3 months and in 21% of patients for ≥1 years. Late AEs occurred in 3.4%. Among patients who were stent-dependent (N=24, 11.6%) and underwent annual stent exchanges, no late AEs occurred. DISCUSSION: Long-term outcomes of EUS-GE are promising with few adverse events, particularly with preemptive annual exchanges of stents to prevent stent delamination and occlusion among patients who require long-term indwelling stents. EUS-GE has an increasing role in access for ERCP in altered anatomy, acute or chronic management of benign GOO, or bridge to definitive surgery for GOO.
Additional file 4: of Red ceramics produced from mixtures of kaolinite clay and waste glass
Creators: name: Tiffo, Emmanuel
name: Elimbi, Antoine
name: Manga, Joseph
name: Tchamba, Arlin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Science Policy

description: Table S4. Chemical composition of waste glass V (LOI = Loss On Ignition).
Development of an inhalable contrast agent targeting the respiratory tract mucus layer for pulmonary ultrasonic imaging
Creators: name: Hill, David B.
name: Rebuli, Meghan E.
name: Sears, Patrick R.
name: Tsuruta, James K.
name: Ostrowski, Lawrence E.
name: Caughey, Melissa C.
name: Durham, Phillip G.
name: Clapp, Phillip W.
name: Weitz, Andrew S.
name: Dayton, Paul A.
Publisher: name: Springer Nature
Year: 2024

description:
Impaired mucociliary transport is a distinguishing sign of cystic fibrosis, but current methods of evaluation are invasive or expose young patients to ionizing radiation. Contrast-enhanced ultrasound imaging may provide a feasible alternative. We formulated a cationic microbubble ultrasound contrast agent, to optimize adhesion to the respiratory mucus layer when inhaled. Potential toxicity was evaluated in human bronchial epithelial cell (hBEC) cultures following a 24-hour exposure, compared to positive and negative control conditions. In vivo tolerability and pulmonary image enhancement feasibility were evaluated in mice, comparing oropharyngeal administration of contrast agent to saline control. When induced to flow across mucus plated on microscope slides, cationic microbubbles demonstrated greater affinity for target samples than standard microbubbles. Cationic microbubbles elicited no proinflammatory or cytotoxic response in hBECs, nor were any cross-links to the cilia observed. Unlike standard microbubbles, cationic microbubbles mixed into the mucus layer, without epithelial absorption, and were observed to move with the mucus layer by the action of mucociliary transport. When administered to mice, cationic microbubbles enhanced sonographic visualization of the trachea, and were well-tolerated with no adverse effects. This developmental work supports the safety and feasibility of a mucus-targeting contrast agent that may be useful for pulmonary ultrasound applications.
Additional file 1: of Red ceramics produced from mixtures of kaolinite clay and waste glass
Creators: name: Tiffo, Emmanuel
name: Elimbi, Antoine
name: Manga, Joseph
name: Tchamba, Arlin
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Table S1. Composition of the mixtures of K and V expressed as mass percentage.
Editorial: CRISPR: the game changer in gene and cell therapy
Creators: name: Bai, Meizhu
name: He, Wenxia
Publisher: name: Frontiers
Year: 2024

description:
Gene and cell therapy has undergone transformative advancements since the first successful gene therapy in 1990, which treated a patient with adenosine deaminase deficiency. Over the decades, these therapies have demonstrated immense potential, yet the advent of CRISPR technology has marked a revolutionary shift in the field. CRISPR’s simplicity, precision, and efficiency have reshaped genome engineering, driving the development of innovative therapies for genetic disorders, cancer, and infectious diseases. This editorial highlights the latest advancements in CRISPR technology, discussing its applications and the ongoing challenges in gene and cell therapy, with insights from recent research under the topic CRISPR—The Game Changer.
Additional file 5: of Patterns of forest composition and their long term environmental drivers in the tropical dry forest transition zone of southern Africa
Creators: name: Cauwer, Vera De
name: Geldenhuys, Coert
name: Raf Aerts
name: Kabajani, Miya
name: Muys, Bart
Publisher: name: Figshare
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Document S5 (DOCX 22Â kb)
Toritrombicula lerdthusneei Takahashi, Misumi and Takahashi 2012
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Toritrombicula
Toritrombicula lerdthusneei

description: Toritrombicula lerdthusneei Takahashi, Misumi and Takahashi, 2012b:
PAL
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 182, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Ophioleucidae Matsumoto 1915
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Ophioleucida
Ophioleucidae

description: Ophioleucidae
- adGP bar-like, distally scoop-shaped, condyle and curved groove, several stereom patches
- abGP wide blade-like, articular structure concave notch
- RS with low condyle, groove, round rough patch
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Additional file 1: of Development of Conductometric Sensor Based on 25,27-Di-(5-thio-octyloxy)calix[4]arene-crown-6 for Determination of Ammonium
Creators: name: O. Saiapina
name: S. Kharchenko
name: S. Vishnevskii
name: V. Pyeshkova
name: V. Kalchenko
name: S. Dzyadevych
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Method of synthesis of 25,27-di-(5-thio-octyloxy)calix[4]arene-crown-6. (DOCX 105 kb)
Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice
Creators: name: Montgomery, Nathan D.
name: Montgomery, Stephanie A.
name: Corcoran, David
name: Liu, Siyao
name: Äijö, Tarmo
name: Gioulbasani, Marianthi
name: Tsagaratou, Ageliki
Publisher: name: Springer Nature
Year: 2024

description:
Ten eleven translocation (TET) proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation and to regulate gene expression. Notably, TET2 is one of the most frequently mutated genes in hematological malignancies, including T cell lymphomas. However, murine models with deletion of TET2 do not exhibit T cell expansion, presumably due to redundancy with other members of the TET family of proteins. In order to gain insight on the TET mediated molecular events that safeguard T cells from aberrant proliferation we performed serial adoptive transfers of murine CD4 T cells that lack concomitantly TET2 and TET3 to fully immunocompetent congenic mice. Here we show a progressive acquisition of malignant traits upon loss of TET2 and TET3 that is characterized by loss of genomic integrity, acquisition of aneuploidy and upregulation of the protooncogene Myc.
MOESM8 of Identification of a new thermostable and alkali-tolerant Îą-carbonic anhydrase from Lactobacillus delbrueckii as a biocatalyst for CO2 biomineralization
Creators: name: Li, Chun-Xiu
name: Jiang, Xiao-Chen
name: Yong-Juan Qiu
name: Xu, Jian-He
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 8: Figure S5. Initial precipitation rates of CaCO3 catalyzed by LdCA at pH 11.0. The intrinsic turbidities of the cells were subtracted from the curves.
Insights into Bullous Pemphigoid: A Comprehensive Review of Diagnostic Modalities
Creators: name: Moshiri, Ata S.
name: Akoh, Christine C.
name: Culton, Donna A.
name: Obijiofor, Chinemelum E.
name: Anyanwu, Nnaemeka
name: Ogah, Ochanya
name: Adotama,
Publisher: name: Elsevier
Year: 2024

description:
Bullous pemphigoid (BP) is an autoimmune blistering disorder associated with profound morbidity. Timely diagnosis of BP is critical for early initiation of therapies, but diagnosis of BP is often challenging. As the pathophysiology of BP has been further elucidated, new diagnostic modalities have been developed. However, it remains unclear which modalities are the most effective for diagnosing BP. In this review article, we provide an updated overview of BP diagnostic modalities, comparing their reported sensitivities and specificities as well as proposing a diagnostic algorithm to help dermatologists navigate diagnosing this complex disease.
Amphilepidida O'Hara, Hugall, Thuy, Stohr & Martynov 2017
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Amphilepidida

description: Amphilepidida
- madreporite inner side with single large opening in varying positions
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Quadriceps Strength Does Not Associate with Gait Adaptation Ability in Individuals with Anterior Cruciate Ligament Reconstruction.
Creators: name: Kiefer, Dr Adam
name: Padua, Dr Darin A
name: Blackburn, Dr J Troy
name: Evans-Pickett, Dr Alyssa
name: Schwartz, Dr Todd A
name: Franz, Dr Jason R
name: Pietrosimone, Dr Brian
Publisher: name: Journal of Athletic Training/NATA
Year: 2024

description:
CONTEXT: Postoperative muscle weakness contributes to the development of aberrant gait biomechanics that persist following traditional anterior cruciate ligament reconstruction (ACLR). However, it is unknown if quadriceps weakness impedes the ability of ACLR patients to modify gait biomechanics using a real-time gait biofeedback (RTGBF) intervention. OBJECTIVE: The purpose was to determine if quadriceps strength associates with the ability to modify vertical ground reaction force (vGRF) during a RTGBF intervention. DESIGN: Cross-Sectional Study. SETTING: Research Laboratory. PARTICIPANTS: 35 individuals with unliateral ACLR (Time since ACLR= 32 ± 16 months; 22 Females, 13 Males). MAIN OUTCOME MEASURES: Peak vGRF was evaluated during a baseline walking trial, and three 250-step randomized RTGBF walking trials which cued an increased average peak vGRF of the baseline walking trial by 5%, 10%, or 15%. The ability to modify gait was reported as changes in pvGRF (ΔpvGRF; BW) and root mean square error (RMSE) of the peak vGRF relative to the feedback target (pvGRF RMSE; BW). We also calculated quadriceps strength. RESULTS: There were no significant associations between strength (Mean: 2.56 ± 0.75 Nm/kg, Range: 0.84-4.6 Nm/kg) and ΔpvGRF (5% ΔpvGRF: 0.04 ± 0.03 BW, 10% ΔpvGRF: 0.10 ± 0.03 BW, 15% ΔpvGRF: 0.15 ± 0.04 BW) nor strength and RMSE (5% RMSE: 0.04 ± 0.02 BW, 10% RMSE: 0.05 ± 0.02 BW, 15% RMSE: 0.08 ± 0.04 BW) for any of the 3 RTGBF trials (R2: 0.003-0.025; P: 0.37-0.77). CONCLUSIONS: The magnitude of quadriceps strength did not influence the ability to modify gait using RTGBF. These data suggest that it may be unnecessary to wait for quadriceps full strength recovery to capitalize on the benefits of RTGBF following ACLR.
Current state and future prospects of spatial biology in colorectal cancer
Creators: name: Ninova, Maria
name: Velazquez-Villarreal, Enrique
name: Diaz, Fernando C.
name: Carranza, Francisco G.
Publisher: name: Frontiers
Year: 2024

description:
Over the past century, colorectal cancer (CRC) has become one of the most devastating cancers impacting the human population. To gain a deeper understanding of the molecular mechanisms driving this solid tumor, researchers have increasingly turned their attention to the tumor microenvironment (TME). Spatial transcriptomics and proteomics have emerged as a particularly powerful technology for deciphering the complexity of CRC tumors, given that the TME and its spatial organization are critical determinants of disease progression and treatment response. Spatial transcriptomics enables high-resolution mapping of the whole transcriptome. While spatial proteomics maps protein expression and function across tissue sections. Together, they provide a detailed view of the molecular landscape and cellular interactions within the TME. In this review, we delve into recent advances in spatial biology technologies applied to CRC research, highlighting both the methodologies and the challenges associated with their use, such as the substantial tissue heterogeneity characteristic of CRC. We also discuss the limitations of current approaches and the need for novel computational tools to manage and interpret these complex datasets. To conclude, we emphasize the importance of further developing and integrating spatial transcriptomics into CRC precision medicine strategies to enhance therapeutic targeting and improve patient outcomes.
Predictors of maternal HIV acquisition during pregnancy and lactation in sub-Saharan Africa: A systematic review and narrative synthesis
Creators: name: Chi, Benjamin H.
name: Graybill, Lauren A.
name: Richardson, Brian D.
name: Hodges, Jasmine N.
name: Mutale, Wilbroad
name: Powers, Kimberly A.
name: Bissram, Jennifer S.
name: Mollan, Katie R.
name: Rosenberg, Nora E.
name: Saidi, Friday
name: Kasaro, Margaret
name: Freeborn, Kellie
name: Hamoonga, Twaambo E.
Publisher: name: Public Library of Science (PLoS)
Year: 2024

description:
OBJECTIVES: To eliminate vertical transmission of HIV, global institutions recommend using a risk-guided approach for HIV prevention services in antenatal and postnatal settings. Identifying predictors of maternal HIV acquisition can inform the development of risk-guided approaches, but individual studies of predictors can have limited power and generalizability. METHODS: We conducted a systematic review and narrative synthesis to identify common predictors of maternal HIV acquisition in sub-Saharan Africa (SSA). We searched four databases for full-text articles that estimated associations between at least one predictor and risk of HIV acquisition among pregnant and/or lactating women (PLW) in SSA. We restricted our synthesis to predictors assessed in at least four study populations. For these predictors, we summarized how each predictor was defined and used vote counting and descriptive statistics to characterize overall trends. RESULTS: We identified 26 eligible publications that summarized results from 24 unique studies. Studies were implemented in 12 countries between 1988 and 2021 and enrolled a total of 164,480 PLW at risk of acquiring HIV. Of the 66 predictors evaluated, 16 met our inclusion criteria. Estimated associations tended to be imprecise and variability in how predictors were measured precluded meta-analyses. We observed trends towards a higher risk of maternal HIV acquisition among young women and women who reported early coital debut, multiple partnerships, sexually transmitted infections, being unaware of partner HIV status, or having a partner living with HIV. In most studies, PLW in stable, monogamous relationships experienced a lower risk of acquiring HIV than those who were single, separated, or in a polygynous marriage. HIV risk perception, condom use, and vaginal drying were also commonly associated with HIV acquisition risk. CONCLUSIONS: In our systematic review and narrative synthesis, we identified several easily measured characteristics that were associated with HIV acquisition among PLW in multiple study populations across SSA. Such findings can support the development and refinement of risk-guided approaches for HIV prevention in the region.
Additional file 1: of Assessing economic impact of research and innovation originating from public research institutions and universitiesâ  case of Singapore PRIs
Creators: name: Cheah, Sarah
name: Yu, Christopher
Publisher: name: Figshare
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Translation of the abstract into Arabic. (PDF 124 kb)
Ophienigma Stohr & Segonzac 2005
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Amphilepidida
Ophienigma

description: Incertae sedis (Ophiopus,
Ophienigma)
- oral GP unknown
- adGP wrench-shaped
- abGP sickle-shaped, low condyle
- centro-distal opening in inner madreporite
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874
Epidemiology, Pathophysiology, and Management of Cancer-Associated Ischemic Stroke
Creators: name: Ryan, Dylan
name: Shekhar, Shashank
name: Feng, Wuwei
name: Ikramuddin, Salman
name: Sengupta, Soma
name: Bou Dargham, Tarek
Publisher: name: MDPI
Year: 2024

description:
Cancer and stroke are leading causes of global disability and mortality. With improvements in cancer-associated mortality and advancements in treatment of active malignancy, it is more common to encounter patients with ischemic stroke and active malignancy. Evidence suggests that cancer-associated ischemic stroke is a unique subtype of stroke; however, there is limited guidance when considering diagnostic workup, secondary prevention, rehabilitation, and future directions within this population. In this narrative review, we aim to describe the epidemiology, pathophysiological mechanisms, management, and future directions regarding understanding of cancer-associated ischemic stroke.
MOESM9 of Identification of a new thermostable and alkali-tolerant Îą-carbonic anhydrase from Lactobacillus delbrueckii as a biocatalyst for CO2 biomineralization
Creators: name: Li, Chun-Xiu
name: Jiang, Xiao-Chen
name: Yong-Juan Qiu
name: Xu, Jian-He
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 9: Figure S6. Initial precipitation rates of CaCO3 catalyzed by LdCA at pH 10.0. The intrinsic turbidities of the cells were subtracted from the curves.
Ophiolepidoidea Ljungman 1867
Creators: name: Stöhr, Sabine
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Echinodermata
Ophiuroidea
Amphilepidida

description: Ophionereidina
Ophiolepidoidea
- central opening in inner madreporite (unknown in Hemieuryale)
description: Published as part of Stöhr, Sabine, 2024, Taxonomic analysis of the genital plates and associated structures in Ophiuroidea (Echinodermata), pp. 1-98 in European Journal of Taxonomy 933 on page 73, DOI: 10.5852/ejt.2024.933.2525, http://zenodo.org/record/11198874