cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The influence of spatial scaffold properties on the interaction between cells and embedded growth factors
Creators: name: Schmidt, Jeroen
Publisher: name: Figshare
Year: 2019
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: While modern-day healthcare continues to improve in terms of available treatments and life expectancy in many countries, increasing costs of providing medical services to aging populations place these systems under increasingly severe pressure. With continuing increases in chronic afflictions and ailments related to old age, more cost-efficient and long-term solutions are needed to meet these challenges.Regenerative medicine offers the potential for more effective long-term treatments, but is hindered by the high cost of the desired treatments in terms of development and implementation, owing to the complexity of the living materials used for such therapies.The work described in this thesis focuses on improving the level of control over the local cellular environment in order to reduce the need for costly materials (especially growth factors). Both surface topology and immobilization of growth factors have previously been shown to have an impact, and this research investigates potential interaction between these aspects. Patterning and immobilization of bio-active compounds are combined for the culture of human mesenchymal stem cells on surfaces with differently scaled patterns and concentrations of immobilized TGF-β1.Initial work focused on the creation of patterned surfaces with feature sizes ranging from 1 to 50 µm. Patterns were successfully produced in Poly (Ethylene Glycol), Polystyrene and Polycaprolactone surfaces using a microparticle-based moulding process.Further work resulted in the successful immobilization of TGF-β1 onto chemically modified surfaces, chiefly Polycaprolactone. Proteins were successfully immobilized onto Polycaprolactone surfaces at concentrations up to 4 pmol/cm2, with exact concentrations dependent on the parameters of the immobilization process.Finally, the developed methods were combined in a hybrid experiment using both patterned surfaces and growth factor immobilization. Results demonstrated a probable link between surface patterning and the effectiveness of immobilized growth factors, although further work is needed to more accurately describe any underlying processes.
Dominant-Negative Loss of PPAR  Function Enhances Smooth Muscle Cell Proliferation, Migration, and Vascular Remodeling
Creators: name: Stouffer, G. A.
name: Panchatcharam, M.
name: Miriyala, S.
name: Smyth, S. S.
name: Tsai, Y.-S.
name: Meredith, D.
name: Maeda, N.
name: Morris, A. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The Peroxisome Proliferator Activated Receptor-gamma (PPARγ) protein is a nuclear transcriptional activator with importance in diabetes management as the molecular target for the thiazolidinedione (TZD) family of drugs. Substantial evidence indicates that the TZD family of PPARγ agonists may retard the development of atherosclerosis. However, recent clinical data has suggested that at least one TZD may increase the risk of myocardial infarction and death from cardiovascular disease. In this study, we used a genetic approach to disrupt PPARγ signaling to probe the protein's role in smooth muscle cell (SMC) responses that are important for atherosclerosis.
Pearl Millet Production Guide
Creators: name: Wandulu, Joseph
name: Lubadde, Geofrey
name: Among, Eunice
Publisher: name: ITPGRFA
Year: 2020
Subjects: ITPGRFA-BSF
Pathogens and diseases
Farmers
Production
Millet
UGA
W2A-PR-115
Sustainable agriculture
Farmers practices
Yields
Organic farming

description: Pearl millet (Pennisetum glaucum), also known as bulrush, cattail or candle millet, is the most drought and soil acid tolerant in Africa. It can be used as food, feed, forrage and cover green manure. It withstands long spells of drought with the ability to regenerate productive nodal and basal tillers to compensate for losses caused by unfavourable conditions. This makes it the most assured cereal crop for drought-prone areas of Uganda.It is grown mainly in northern (Kitgum, Lamwo, Pader and Agago), northeastern (Kaabong and Kotido) and eastern Uganda where Teso region (especially Katakwi and Kumi districts) dominates. It has local names such as raa in Acholi, erau in Karamajong.

This production guide was prepared as an easy to use guide providing farmers and field practitioners with useful information on the necessary steps for the Pearl Millet millet production including, land preparation, planting, inter-cropping, fertilizers application, weeeding etc. They also provided useful information on its commercial value, the modalities for storage and pest control, seed bed preparation planting and common disease management.  This guide was developed as part of the implementation of the project “Strengthening Seed Delivery System for Dryland Cereals and Legumes in Drought-prone Areas of Uganda” funded in the 3rdcycle of the Benefit Sharing Fund (BSF) of the International Treaty on Plant Genetic Resources for Food and Agriculture (ITPGRFA) of the Food and Agriculture Organization (FAO) with financial support from the European Union (Eu)
Additional file 2 of Leukocyte- and platelet-rich fibrin in endoscopic endonasal skull base reconstruction: study protocol for a multicenter prospective, parallel-group, single-blinded randomized controlled non-inferiority trial
Creators: name: Coucke, Birgit
name: Van Hoylandt, Anaïs
name: Jorissen, Mark
name: Meulemans, Jeroen
name: Decramer, Thomas
name: van Loon, Johannes
name: Vander Poorten, Vincent
name: Theys, Tom
name: Van Gerven, Laura
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 2. Informed consent.
Additional file 4 of Individual competence predominates over host nutritional status in Arabidopsis root exudate-mediated bacterial enrichment in a combination of four Burkholderiaceae species
Creators: name: Cillero, Javier Ignacio
name: Henríquez, Pablo Andrés
name: Ledger, Thomas Warwick
name: Ruz, Gonzalo Andrés
name: González, Bernardo
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 4. Graphic representation of the elbow method to discriminate number of clusters.
Topological Symmetry Groups of Complete Bipartite Graphs
Creators: name: Hake, Kathleen
name: Mellor, Blake
name: Pittluck, Matthew
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 57M25, 05C10

description: The symmetries of complex molecular structures can be modeled by the {\em topological symmetry group} of the underlying embedded graph. It is therefore important to understand which topological symmetry groups can be realized by particular abstract graphs. This question has been answered for complete graphs; it is natural next to consider complete bipartite graphs. In previous work we classified the complete bipartite graphs that can realize topological symmetry groups isomorphic to $A_4$, $S_4$ or $A_5$; in this paper we determine which complete bipartite graphs have an embedding in $S^3$ whose topological symmetry group is isomorphic to $\mathbb{Z}_m$, $D_m$, $\mathbb{Z}_r \times \mathbb{Z}_s$ or $(\mathbb{Z}_r \times \mathbb{Z}_s) \ltimes \mathbb{Z}_2$.
description: 26 pages, minor revisions; this is the final version accepted by Tokyo Journal of Mathematics
G Protein-Coupled Receptors as Potential Drug Targets for Lymphangiogenesis and Lymphatic Vascular Diseases
Creators: name: Dunworth, W. P.
name: Caron, K. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: G-protein coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety of human diseases. Recent studies in genetically engineered mouse models have led to the identification of several GPCRs important for lymphatic vascular development and function. The adrenomedullin receptor, which consists of an oligomer between calcitonin receptor-like receptor and receptor activity modifying protein 2, is required for normal lymphatic vascular development and regulates lymphatic capillary permeability in mice. Numerous studies also suggest that lysophospholipid receptors are involved in the development of lymphatic vessels and lymphatic endothelial cell permeability. Given our current lack of pharmacological targets for the treatment of lymphatic vascular diseases like lymphedema, the continued identification and study of GPCRs in lymphatic endothelial cells may eventually lead to major breakthroughs and new pharmacological strategies for the treatment of lymphedema.
Consistently violating the non-Gaussian consistency relation
Creators: name: Mooij, Sander
name: Palma, Gonzalo A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Non-attractor models of inflation are characterized by the super-horizon evolution of curvature perturbations, introducing a violation of the non-Gaussian consistency relation between the bispectrum's squeezed limit and the power spectrum's spectral index. In this work we show that the bispectrum's squeezed limit of non-attractor models continues to respect a relation dictated by the evolution of the background. We show how to derive this relation using only symmetry arguments, without ever needing to solve the equations of motion for the perturbations.
description: 26 pages, v3: matches published version (JCAP)
Hemostasis, Inflammation, and Fatal and Nonfatal Coronary Heart Disease: Long-Term Follow-Up of the Atherosclerosis Risk in Communities (ARIC) Cohort
Creators: name: Siscovick, D. S.
name: Sotoodehnia, N.
name: Rea, T. D.
name: Folsom, A. R.
name: Chakravarti, A.
name: Prineas, R. J.
name: Kucharska-Newton, A. M.
name: Pankow, J. S.
name: Couper, D. J.
name: Rosamond, W. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: This study examines the hypothesis that chronic inflammation is associated with a higher risk of cardiac death compared to the risk of non-fatal myocardial infarction.
Families with Farm Income: Their Income, Income Distribution, and Income Sources
Creators: name: Crecink, John C.
name: Crecink, John C.
Publisher: name: Unknown
Year: 1979
Subjects: subject: Consumer/Household Economics
subject: Financial Economics
subject: Food Security and Poverty
subject: Research Methods/ Statistical Methods
subject: Net farm income
subject: off-farm income
subject: income
subject: income sources
subject: small farms
subject: low-income farms
subject: families with farm income

description: This report utilizes data from the Farm Family Living Expenditures Survey of 1973. Nationally, total income for farm families is becoming more equally distributed. Low-farm incomes or even negative farm income does not necessarily indicate a low family income because over 90 percent of the families had income from at least one other source in addition to farming. Most low-income farm families were concentrated in the South, particularly in the Appalachian and Delta region. The Corn Belt also had a sizeable number of farm families whose income was below the poverty threshold.
Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Liver Cancer Among Postmenopausal Women
Creators: name: Linet, M.S.
name: Chen, Y.
name: Zhang, X.
name: Hofmann, J.N.
name: Stanczyk, F.Z.
name: Liao, L.M.
name: Caron, P.
name: Zeleniuch-Jacquotte, A.
name: Giovannucci, E.
name: Rosenberg, L.
name: Petrick, J.L.
name: Bradwin, G.
name: Gaziano, J.M.
name: Lee, I.-M.
name: Kirsh, V.A.
name: Wactawski-Wende, J.
name: Rohan, T.E.
name: Chong, D.Q.
name: Campbell, P.T.
name: Graubard, B.I.
name: Gapster, S.M.
name: Simon, T.G.
name: Van Den Eeden, S.K.
name: Schairer, C.
name: Guillemette, C.
name: Chan, A.T.
name: Purdue, M.P.
name: Kitahara, C.M.
name: Koshiol, J.
name: McGlynn, K.A.
name: Sinha, R.
name: Engel, L.S.
name: Beane Freeman, L.E.
name: Sesso, H.D.
name: Florio, A.A.
name: Freedman, N.D.
name: Buring, J.E.
name: Palmer, J.R.
Publisher: name: John Wiley and Sons Inc
Year: 2020

description: Background and Aims: In almost all countries, incidence rates of liver cancer (LC) are 100%-200% higher in males than in females. However, this difference is predominantly driven by hepatocellular carcinoma (HCC), which accounts for 75% of LC cases. Intrahepatic cholangiocarcinoma (ICC) accounts for 12% of cases and has rates only 30% higher in males. Hormones are hypothesized to underlie observed sex differences. We investigated whether prediagnostic circulating hormone and sex hormone binding globulin (SHBG) levels were associated with LC risk, overall and by histology, by leveraging resources from five prospective cohorts. Approach and Results: Seven sex steroid hormones and SHBG were quantitated using gas chromatography/tandem mass spectrometry and competitive electrochemiluminescence immunoassay, respectively, from baseline serum/plasma samples of 191 postmenopausal female LC cases (HCC, n = 83; ICC, n = 56) and 426 controls, matched on sex, cohort, age, race/ethnicity, and blood collection date. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations between a one-unit increase in log2 hormone value (approximate doubling of circulating concentration) and LC were calculated using multivariable-adjusted conditional logistic regression. A doubling in the concentration of 4-androstenedione (4-dione) was associated with a 50% decreased LC risk (OR = 0.50; 95% CI = 0.30-0.82), whereas SHBG was associated with a 31% increased risk (OR = 1.31; 95% CI = 1.05-1.63). Examining histology, a doubling of estradiol was associated with a 40% increased risk of ICC (OR = 1.40; 95% CI = 1.05-1.89), but not HCC (OR = 1.12; 95% CI = 0.81-1.54). Conclusions: This study provides evidence that higher levels of 4-dione may be associated with lower, and SHBG with higher, LC risk in women. However, this study does not support the hypothesis that higher estrogen levels decrease LC risk. Indeed, estradiol may be associated with an increased ICC risk.
Design strategies for the exploration of product meaning in meaning-driven innovation
Creators: name: Kraszewski, Daniel
Publisher: name: Figshare
Year: 2019
Subjects: subject: 120399 Design Practice and Management not elsewhere classified
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Design has been framed as a driver of innovation through product meaning, but it falls short when it comes to dedicated knowledge and methods directly applicable into design practices. Structured by Design Research Methodology (DRM) (Blessing and Chakrabarti 2009), this thesis combines exploratory research with practice-based design research. This thesis presents a literature review covering design studies, psychology, cognitive semantics, linguistics, marketing, innovation management and new product development. Together combined these have been used to develop a new framework of ‘product meaning’ consisting of 4 definitions: meaning as conceptualisation, as importance, as intention, and as representation. The framework has been used to demonstrate that different types of meaning are utilised throughout different stages of product development. Meaning as conceptualisation is identified as fundamental, and the most suitable, for design practice engaged in product meaning innovation. Three strategies of innovation of product meaning through product re-purposing are identified. Furthermore, from the field of cognitive science, theories and methods such as concept categorisation, thematic roles and conceptual blending are used as analysis tools for the selected 6 examples of innovative new meaning products. The structure of meaning innovations has been identified to consist of seven distinctive elements. Ten common characteristics of new meaning innovations are identified and, additionally, an exploratory method of current meanings of products is presented. Moreover, through engagement in practice-based design research a new meaning-driven design process has been developed. The findings from this research have been combined into a new design platform for an approach to meaning innovation and evaluated with experienced designers.
The next challenge: data management, submission and FAIRness in multi-omics experiments
Creators: name: Giannattasio, Sergio
name: Heil, Katharina F
name: Hermjakob, Henning
name: Hooft, Rob W W
name: Klapa, Maria I
name: Mastrorocco, Fabrizio
name: Neumann, Steffen
name: O'Donovan, Claire
name: Payne, Thomas
name: Yasset Perez-Riverol
name: Prigent, Sylvain
name: Thévenot, Etienne A
Publisher: name: F1000 Research Limited
Year: 2023

description: The Workshop “The next challenge: data management, submission and FAIRness in multi-omics experiments” was organised as part of the ELIXIR AllHands Meeting 2023 in Dublin, Ireland.
 The ELIXIR data platform and several resources are available to submit metabolomics, transcriptomics, proteomics and other Omics data. While multi-omics analyses and data are getting common in more and more research projects, data management, sharing and FAIRness is currently focussing on individual single-omics submissions.
 In this workshop, several users reported their experience from projects and infrastructures generating multi-omics data, covering individual approaches, good experience and lessons learned. In a second block, the Metabolights and PRIDE repositories and their approach to linking to other-omics data were introduced. Finally, the life-science Omics-DI meta-search engine was presented. After the presentations, local and remote attendees engaged in a lively and constructive discussion.
 The expected increasing number of multi-omics submissions only underlines the need to improve and harmonise the submission processes, to reduce the friction happening when multiple stakeholders are involved in the data and scholarly publication processes. The efforts that go into FAIR multi-omics experiment data submissions can really bloom if we simplify the re-use of the data. We are convinced that the Bioinformatics community, and ELIXIR in particular, will be instrumental in the coming years, and specifically in the ELIXIR 2024-28 work programme.
Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore
Creators: name: Langseth, H.
name: Davis, M.
name: Bassig, B.A.
name: Engel, L.S.
name: Koh, W.-P.
name: Wong, J.Y.Y.
name: Hu, W.
name: Grimsrud, T.K.
name: Chen, D.
name: Hosgood, H.D.
name: Jones, R.S.
name: Gao, Y.-T.
name: Wang, R.
name: Lan, Q.
name: Shu, X.-O.
name: Yang, G.
name: Xiang, Y.-B.
name: Sjödin, A.
name: Ji, B.-T.
name: Seow, W.J.
name: Adams-Haduch, J.
name: Zheng, W.
name: Purdue, M.P.
name: Yuan, J.-M.
name: Rothman, N.
Publisher: name: Wiley-Liss Inc.
Year: 2020

description: Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case–control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0–3.2; ptrend = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1–3.9; ptrend = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p′-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p′-DDE do not support an association.
PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling
Creators: name: Chen, Z.
name: Tzima, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Vascular remodeling is a physiological process that occurs in response to long-term changes in hemodynamic conditions, but may also contribute to the pathophysiology of intima-media thickening (IMT) and vascular disease. Shear stress detection by the endothelium is thought to be an important determinant of vascular remodeling. Previous work showed that Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a component of a mechanosensory complex that mediates endothelial cell (EC) responses to shear stress.
Supernova 1987A: neutrino-driven explosions in three dimensions and light curves
Creators: name: Utrobin, Victor
name: Wongwathanarat, Annop
name: Janka, H. -Thomas
name: Mueller, Ewald
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The well-studied type IIP SN 1987A, produced by the explosion of a blue supergiant (BSG) star, is a touchstone for massive-star evolution, simulations of neutrino-driven explosions, and modeling of light curves and spectra. In the framework of the neutrino-driven mechanism, we study the dependence of explosion properties on the structure of four different BSGs and compare the corresponding light curves with observations of SN 1987A. We perform 3D simulations with the PROMETHEUS code until about one day and map the results to the 1D code CRAB for the light curve calculations. All of our 3D models with explosion energies compatible with SN 1987A produce 56Ni in rough agreement with the amount deduced from fitting the radioactively powered light-curve tail. One of the progenitors yields maximum velocities of ~3000 km/s for the bulk of ejected 56Ni, consistent with observations. In all of our models inward mixing of hydrogen during the 3D evolution leads to minimum H-velocities below 100 km/s, in good agreement with spectral observations. The considered BSG models, 3D explosion simulations, and light-curve calculations can thus explain basic observational features of SN 1987A. However, all progenitors have too large pre-SN radii to reproduce the narrow initial luminosity peak, and the structure of their outer layers is not suitable to match the observed light curve during the first 30-40 days. Only one stellar model has a structure of the He core and the He/H composition interface that enables sufficient outward mixing of 56Ni and inward mixing of hydrogen to produce a good match of the dome-like shape of the observed light-curve maximum. But this model falls short of the He-core mass of 6 Msun inferred from the absolute luminosity of the pre-SN star. The lack of an adequate pre-SN model for SN 1987A is a pressing challenge for the theory of massive-star evolution. (Abridged)
description: 18 pages, 11 figures, 4 tables; revised version, accepted by Astron. Astrophys
Training III: Analyzing an All of Us dataset and other helpful tools
Creators: name: Coleman, Julie
name: Baker, Jasmine
name: Ketkar, Shamika
name: Butler, Ashley
name: LaTerrica Williams
name: Atkinson, Elizabeth
name: Worley, Kim
name: Murray, Debra
name: Lee, Brendan
Publisher: name: F1000 Research Limited
Year: 2023

description: This training demonstrates how to save and retrieve All of Us data from a Workspace Bucket using code snippets available in an All of Us Jupyter Notebook. It also demonstrates how to back up an All of Us Jupyter Notebook. Quality checking and cleaning All of Us data followed by potential statistical and plotting analyses are reviewed. Last, how to export results from an All of Us Jupyter Notebook is demonstrated.
Additional file 7 of Evaluation of a blended learning approach on stratified care for physiotherapy bachelor students
Creators: name: Adje, Mishael
name: Steinhäuser, Jost
name: Laekeman, Marjan
name: Rogan, Slavko
name: Karstens, Sven
Publisher: name: figshare
Year: 2023
Subjects: Neuroscience
Science Policy
Mental Health

description: Supplementary Material 7
Storytelling political theory and an anti-homeless public space
Creators: name: Stevens, Simon
Publisher: name: Figshare
Year: 2019
Subjects: subject: 169999 Studies in Human Society not elsewhere classified
subject: FOS: Sociology

description: This thesis investigates the present reality of an anti-homeless public space and its construction of the street homeless subject, with normative conclusions. The recent history of various tactics of dispersal and their interconnection are revealed. I argue that it is not just archaic laws and legislative heirs to such laws which impede the survival of the street homeless, but the physicality of public space itself. Prior to presenting this case however, I first engage in an examination of political theory methods. I do this to form a storytelling method suited to the task of, but not limited to, exploring an anti-homeless public space.
Halo mass function: Baryon impact, fitting formulae and implications for cluster cosmology
Creators: name: Bocquet, Sebastian
name: Saro, Alex
name: Dolag, Klaus
name: Mohr, Joseph J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use a set of hydrodynamical (Hydro) and dark matter only (DMonly) simulations to calibrate the halo mass function (HMF). We explore the impact of baryons, propose an improved parametrization for spherical overdensity masses and identify differences between our DMonly HMF and previously published HMFs. We use the \textit{Magneticum} simulations, which are well suited because of their accurate treatment of baryons, high resolution, and large cosmological volumes of up to $(3818~\textrm{Mpc})^3$. Baryonic effects globally decrease the masses of galaxy clusters, which, at a given mass, results in a decrease of their number density. This effect vanishes at high redshift $z\sim2$ and for high masses $M_{200\textrm m}\gtrsim10^{14}M\odot$. We perform cosmological analyses of three idealized approximations to the cluster surveys by the South Pole Telescope (SPT), \textit{Planck}, and eROSITA. We pursue two main questions: (1) What is the impact of baryons? -- For the SPT-like and the \textit{Planck}-like samples, the impact of baryons on cosmological results is negligible. In the eROSITA-like case, however, neglecting the baryonic impact leads to an underestimate of $Ω_\textrm m$ by about $0.01$, which is comparable to the expected uncertainty from eROSITA. (2) How does our DMonly HMF compare with previous work? -- For the \textit{Planck}-like sample, results obtained using our DMonly HMF are shifted by $Δ(σ_8)\simeqΔ(σ_8(Ω_\textrm m/0.27)^{0.3})\simeq0.02$ with respect to results obtained using the Tinker et al. (2008) fit. This suggests that using our HMF would shift results from \textit{Planck} clusters toward better agreement with CMB anisotropy measurements. Finally, we discuss biases that can be introduced through inadequate HMF parametrizations that introduce false cosmological sensitivity.
description: Accepted for publication in MNRAS; 14 pages, 8 figures
PKA-Dependent Phosphorylation of Serum Response Factor Inhibits Smooth Muscle-Specific Gene Expression
Creators: name: Mack, C. P.
name: Taylor, J. M.
name: Blaker, A. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Our goal was to identify phosphorylation sites that regulate serum response factor (SRF) activity to gain a better understanding of the signaling mechanisms that regulate SRF’s involvement in smooth muscle cell (SMC)-specific and early response gene expression.
Filtros Oftalmicos y su Implementación en Condiciones Oftalmológicas Durante la Atención del Tecnólogo Médico.pdf
Creators: name: Bello Ramirez, Joaquín
name: Zapata, Benjamin
Publisher: name: figshare
Year: 2022
Subjects: subject: 111303 Vision Science
subject: FOS: Clinical medicine

description: Durante varios años los filtros oftálmicos han generado opiniones divididas entre los profesionales del área óptica. Por un lado, se ha indicado que los filtros corresponden meramente a una estrategia comercial del mercado de las ópticas, las cuales lucrarían recetando lentes con filtros que son innecesarios para los pacientes, no obstante, también se ha descrito que estos filtros aportarían diversos beneficios a los pacientes como protección ocular, prevención de enfermedades y hasta mejoras de ciertos cuadros sintomáticos. El proyecto de investigación tiene como propósito realizar una revisión bibliográfica sobre las investigaciones realizadas en la última década sobre el uso de filtros oftálmicos en patologías u condiciones visuales. Como metodología se realizará una investigación no experimental, analítica, transversal y retrospectiva de estudios que cumplan con los criterios de inclusión. De esta manera, se tiene como objetivo indagar en el contenido de estas publicaciones para determinar si existe una relación directa entre filtros oftálmicos y mejoras en la percepción visual en pacientes con patologías u condiciones oftalmológicas. Los resultados se obtuvieron a través de la revisión bibliográfica de 50 investigaciones. Dentro de estas investigaciones, el filtro azul fue el más prevalentes con un total de 15 investigaciones, de las cuales, en su mayoría se apoyó el uso de este filtro. Finalmente se determina que el 30% refuta el uso de filtros oftálmicos, indicando que la percepción visual de pacientes con patologías con oftalmológicas no mejora con el uso de estos, sin embargo, el 70% de estos estudios apoyan el uso de filtros oftálmicos en pacientes con patologías oftalmológicas, indicando mejorías en la percepción visual de estos pacientes, confirmando la hipótesis planteada
Supplementary document for Active-illumination extension to the Priest and Meier pBRDF - 6622408.pdf
Creators: name: Spencer, Mark
name: Hyde, Milo
name: Bose-Pillai, Santasri
name: Marciniak, Michael
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Classical and Physical Optics

description: Active-illumination extension to the Priest and Meier pBRDF: Supplemental document
Additional file 3 of Leukocyte- and platelet-rich fibrin in endoscopic endonasal skull base reconstruction: study protocol for a multicenter prospective, parallel-group, single-blinded randomized controlled non-inferiority trial
Creators: name: Coucke, Birgit
name: Van Hoylandt, Anaïs
name: Jorissen, Mark
name: Meulemans, Jeroen
name: Decramer, Thomas
name: van Loon, Johannes
name: Vander Poorten, Vincent
name: Theys, Tom
name: Van Gerven, Laura
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Additional file 3. SPIRIT 2013 Checklist.
Prediagnostic serum polychlorinated biphenyl concentrations and primary liver cancer: A case-control study nested within two prospective cohorts
Creators: name: Widell, A.
name: O'Brien, T.R.
name: Grimsrud, T.K.
name: Niehoff, N.M.
name: Van Den Eeden, S.K.
name: Engel, L.S.
name: Rothman, N.
name: Zhang, M.
name: Zabor, E.C.
name: Satagopan, J.
Publisher: name: Academic Press Inc.
Year: 2020

description: Background: Polychlorinated biphenyls (PCBs) were used in electrical equipment and a range of construction materials. Although banned in the United States and most of Europe in the 1970s, they are highly persistent in the environment and bioaccumulate. Whether PCBs are associated with liver cancer risk at general population levels is unknown. Methods: This study consisted of 136 incident liver cancer cases and 408 matched controls from the Kaiser Permanente Northern California Multiphasic Health Checkup (MHC) cohort and 84 cases and 252 matched controls from the Norwegian Janus cohort. Sera collected in the 1960s–1980s were measured for 37 PCB congeners and markers of hepatitis B (HBV) and C (HCV) infection. Odds ratios (OR) and 95% confidence intervals (CI) for tertiles of each lipid-adjusted PCB were estimated from conditional logistic regression. We also examined the molar sum of congeners in groups: total PCBs; low, medium, and high chlorination; and Wolff functional groups. Results: Concentrations of individual congeners from the 1960s/1970s sera ranged from 1.3-123.0 and 1.4–116.0 ng/g lipid among MHC cases and controls, respectively, and from 1.9-258.0 and 1.9–271.0 ng/g lipid among Janus cases and controls, respectively. Among MHC participants with sera from the 1960s, collected an average of 27 years before diagnosis among cases, the top tertile of PCBs 151, 170, 172, 177, 178, 180, and 195 was significantly associated with elevated odds of liver cancer (OR range = 2.01–2.38); most of these congeners demonstrated exposure-response trends. For example, ORtertile 3vs1 = 2.38 (95% CI: 1.22–4.64, p-trend = 0.01) for PCB 180. As a group, Wolff group 1b congeners, which are biologically persistent and weak phenobarbital inducers, were associated with increased odds. In MHC participants, ever vs. never HBV or HCV infection modified the PCB-liver cancer associations. There was little evidence of an association between PCBs and odds of liver cancer among the Janus cohort. Discussion: We observed associations between a number of PCB congeners and increased odds of liver cancer among MHC, but not Janus, participants with sera from the 1960s/1970s.
A Unified Model of the Fermi Bubbles, Microwave Haze, and Polarized Radio Lobes: Reverse Shocks in the Galactic Center's Giant Outflows
Creators: name: Crocker, Roland M.
name: Bicknell, Geoffrey V.
name: Taylor, Andrew M.
name: Carretti, Ettore
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Galactic Center's giant outflows are manifest in three different, non-thermal phenomena: i) the hard-spectrum, γ-ray `Fermi Bubbles' emanating from the nucleus and extending to |b| ~ 50 degrees; ii) the hard-spectrum, total-intensity microwave (~ 20-40 GHz) `Haze' extending to |b| ~ 35 degrees in the lower reaches of the Fermi Bubbles; and iii) the steep spectrum, polarized, `S-PASS' radio (~ 2-20 GHz) Lobes that envelop the Bubbles and extend to |b| ~ 60 degrees. We find that the nuclear outflows inflate a genuine bubble in each Galactic hemisphere that has the classical structure, working outwards, of reverse shock, contact discontinuity, and forward shock. Expanding into the finite pressure of the halo and given appreciable cooling and gravitational losses, the contact discontinuity of each bubble is now expanding only very slowly. We find observational signatures in both hemispheres of giant, reverse shocks at heights of ~ 1 kpc above the nucleus; their presence ultimately explains all three of the non-thermal phenomena mentioned above. Synchrotron emission from shock-reaccelerated cosmic-ray electrons explains the spectrum, morphology, and vertical extent of the microwave Haze and the polarized radio Lobes. Collisions between shock-reaccelerated hadrons and denser gas in cooling condensations that form inside the contact discontinuity account for most of the Bubbles' γ-ray emissivity.
description: Accepted for publication in the Astrophysical Journal. 14 figures. Qualitative results unchanged from vers. 1 but calculations made more robust and text clarified
Venous Thromboembolism: Risk Factors, Biomarkers, and Treatment
Creators: name: Mackman, N.
name: Wolberg, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Articles in this series: •Zhu T, Martinez I, Emmerich J. Venous thromboembolism: risk factors for recurrence. Arterioscler Thromb Vasc Biol. 2009;29:298–310. •Jang MJ, Choi W, Bang SM, Lee T, Yeo-Kyeoung K, Ageno W, Doyeun Oh. Metabolic syndrome is associated with venous thromboembolism in the Korean population. Arterioscler Thromb Vasc Biol. 2009;29:311–315. •Sousou T, Khorana AA. New insights into cancer-associated thrombosis. Arterioscler Thromb Vasc Biol. 2009;29:316–320. •Farmer-Boatwright MK, Roubey RAS. Venous thrombosis in the antiphospholipid syndrome. Arterioscler Thromb Vasc Biol. 2009;29:321–325. •James AH. Venous thromboembolism in pregnancy. Arterioscler Thromb Vasc Biol. 2009;29:326–331. •Pabinger I, Ay C. Biomarkers and venous thromboembolism. Arterioscler Thromb Vasc Biol. 2009;29:332–336. In 2005, the U.S. Senate declared March as deep vein thrombosis (DVT) awareness month. This is the second year in which we have highlighted this event with a collection of 6 articles in Arteriosclerosis, Thrombosis, and Vascular Biology focused on DVT. It is estimated that 2 million Americans per year develop DVT, which is associated with life-threatening pulmonary embolism (PE). DVT and PE are collectively termed venous thromboembolism (VTE). Despite the large number of cases, a survey conducted by the American Public Health Association in 2002 found that 74% of Americans were unaware of venous thrombosis.1 The risk of VTE increases with thrombophilias, age, pregnancy, and comorbidities, including cancer and antiphospholipid syndrome (APS). It has not yet been determined whether similar mechanisms lead to VTE in each of these disorders. The articles in this issue describe current research into disorders associated with increased VTE risk, including potential pathophysiologic mechanisms, treatment of these clinical situations, and a review on biomarkers for the detection and prevention of VTE. …
Supplementary document for Active-illumination extension to the Priest and Meier pBRDF - 6625273.pdf
Creators: name: Spencer, Mark
name: Hyde, Milo
name: Bose-Pillai, Santasri
name: Marciniak, Michael
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Classical and Physical Optics

description: Active-illumination extension to the Priest and Meier pBRDF: supplemental document
The Frenkel Line: a direct experimental evidence for the new thermodynamic boundary
Creators: name: Bolmatov, Dima
name: Zhernenkov, M.
name: Zav'yalov, D.
name: Tkachev, S. N.
name: Cunsolo, A.
name: Cai, Y. Q.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Supercritical fluids play a significant role in elucidating fundamental aspects of liquid matter under extreme conditions. They have been extensively studied at pressures and temperatures relevant to various industrial applications. However, much less is known about the structural behaviour of supercritical fluids and no structural crossovers have been observed in static compression experiments in any temperature and pressure ranges beyond the critical point. The structure of supercritical state is currently perceived to be uniform everywhere on the pressure-temperature phase diagram, and to change only in a monotonic way even moving around the critical point, not only along isotherms or isobars. Conversely, we observe structural crossovers for the first time in a deeply supercritical sample through diffraction measurements in a diamond anvil cell and discover a new thermodynamic boundary on the pressure-temperature diagram. We explain the existence of these crossovers in the framework of the phonon theory of liquids using molecular dynamics simulations. The obtained results are of prime importance since it implies a global reconsideration of the mere essence of the supercritical phase. Furthermore, this discovery may pave the way to new unexpected applications and to the exploration of exotic behaviour of confined fluids relevant to geo- and planetary sciences.
description: 11 pages, 5 figures
BETA-DECAY RESIDUALS V. KNOWN PARTICLE FLUXES FOR PREDICTION OF TOTAL SOLAR IRRADIANCE VIA MACHINE-LEARNING METHODS
Creators: name: Longman, A
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 510108
subject: Solar physics
classificationCode: 510703
subject: Particle physics
classificationCode: 510601
subject: Nuclear physics
classificationCode: 461199
subject: Machine learning not elsewhere classified

description: Anomalous oscillations in beta-decay have been noticed in data sets across the world, from many different investigators, and in the widest array of instrument types. Scientific literature contains many references to the phenomena which often includes annual periodicities with phase relationship to the earth’s annual orbit about the sun as well as solar-mechanical periodicities which relate to the internal motions of the sun. Over time two camps have appeared in the literature - those who hold that the signals are due to environmental effects or instrument errors, and those who propose new physics based on solar neutrino flux.Here, with a combination of literature review, published experiments, previously unpublished laboratory experiment, and computational machine learning prediction, we advance toward answering the question of which of these two competing hypotheses are correct and propose a design for the next generation of experimental apparatus.
Hazardous air pollutants and telomere length in the Sister Study
Creators: name: Keil, A.P.
name: Gammon, M.D.
name: Niehoff, N.M.
name: Sandler, D.P.
name: White, A.J.
name: Engel, L.S.
name: Taylor, J.A.
name: Nichols, H.B.
Publisher: name: Wolters Kluwer Health
Year: 2019

description: Background: Telomeres are vital for genomic integrity, and telomere length has been linked to many adverse health outcomes. Some hazardous air pollutants or air toxics increase oxidative stress and inflammation, two possible determinants of shortened telomere length. No studies have examined air toxic-Telomere length associations in a nonoccupational setting. Methods: This study included 731 Sister Study participants (enrolled 2003-2007) who were randomly selected to assess telomere length in baseline blood samples. Multiplex qPCR was used to determine telomere to single copy gene (T/S) ratios. Census tract concentration estimates of 29 air toxics from the 2005 National Air Toxics Assessment were linked to baseline residential addresses. Air toxics were classified into tertile-based categories of the exposure. Multivariable linear regression was used to estimate β coefficients and 95% confidence intervals (CIs) in single-pollutant models. Multipollutant groups were identified with regression trees. Results: The average T/S ratio was 1.24. Benzidine (T3 versus T1 β =-0.08; 95% CI =-0.14,-0.01) and 1,4-dioxane (T3 versus T1 β =-0.06; 95% CI =-0.13, 0.00) in particular, as well as carbon tetrachloride, chloroprene, ethylene dibromide, and propylene dichloride, were associated with shorter relative telomere length. Benzidine (P = 0.02) and 1,4-dioxane (P = 0.06) demonstrated some evidence of a monotonic trend. The regression tree identified age, BMI, physical activity, ethylene oxide, acrylonitrile, ethylidene dichloride, propylene dichloride, and styrene in multipollutant groups related to telomere length. Conclusions: In this first study of air toxics and telomere length in a nonoccupational setting, several air toxics, particularly 1,4-dioxane and benzidine, were associated with shorter relative telomere length.
Activation of Protease-Activated Receptors 3 and 4 Accelerates Tissue Factor-Induced Thrombin Generation on the Surface of Vascular Smooth Muscle Cells
Creators: name: Huang, J.
name: Pathak, A.
name: Monroe, D. M.
name: Vidwan, P.
name: Stouffer, G. A.
name: Sheth, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To determine factors regulating human aortic smooth muscle cells (HASMC) supported tissue factor-induced thrombin generation.
Aortic Arch Curvature and Atherosclerosis Have Overlapping Quantitative Trait Loci in a Cross Between 129S6/SvEvTac and C57BL/6J Apolipoprotein E-Null Mice
Creators: name: Maeda, N.
name: Tomita, H.
name: Zhilicheva, S.
name: Kim, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Apolipoprotein E-null mice with a 129S6/SvEvTac strain background (129-apoE) develop atherosclerotic plaques faster in the aortic arch but slower in the aortic root than those with a C57BL/6J background (B6-apoE). The shape of the aortic arch also differs in the two strains.
Developing Large-Scale Research in Response to an Oil Spill Disaster: a Case Study
Creators: name: Blair, A.
name: Gam, K.B.
name: Engel, L.S.
name: Miller, A.K.
name: Curry, M.D.
name: Sandler, D.P.
name: Ramsey, S.K.
name: Kwok, R.K.
Publisher: name: Springer
Year: 2019

description: Research conducted in the wake of a disaster can provide information to help mitigate health consequences, support future recovery efforts, and improve resilience. However, a number of barriers have prevented time-sensitive research responses following previous disasters. Furthermore, large-scale disasters present their own special challenges due to the number of people exposed to disaster conditions, the number of groups engaged in disaster response, and the logistical challenges of rapidly planning and implementing a large study. In this case study, we illustrate the challenges in planning and conducting a large-scale post-disaster research study by drawing on our experience in establishing the Gulf Long-term Follow-up (GuLF) Study following the 2010 Deepwater Horizon disaster. We describe considerations in identifying at-risk populations and appropriate comparison groups, garnering support for the study from different stakeholders, obtaining timely scientific and ethics review, measuring and characterizing complex exposures, and addressing evolving community health concerns and unmet medical needs. We also describe the NIH Disaster Research Response (DR2) Program, which provides a suite of resources, including data collection tools, research protocols, institutional review board guidance, and training materials to enable the development and implementation of time-critical studies following disasters and public health emergencies. In describing our experiences related to the GuLF Study and the ongoing efforts through the NIH DR2 Program, we aim to help improve the timeliness, quality, and value of future disaster-related data collection and research studies.