cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stem Cell Therapy in Veterinary Practice: An Overview
Creators: name: Umang J Dubariya¹*, Monali B Bhaesaniya2, S. H. Zalavadiya3
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: Regenerative medicine is a branch of medicine that develops methods to grow, repair, or replace damaged or diseased cells, organs or tissues. It has gained significant momentum in recent years. Stem cells are undifferentiated cells with the capability to self—renew and differentiate into tissue cells with specialized functions. Stem cell therapies are therefore used to overcome the body’s inability to regenerate damaged tissues and metabolic processes after acute or chronic insult.
Social Comparison in Narrative Persuasion: When Struggling Characters Serve as Motivation
Creators: name: Robinson, Melissa J.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The effects of gain and loss frames have been examined extensively, but there can be more nuance in health narratives. Experimental research with narratives has not yet thoroughly investigated all combinations of protagonists’ health recommendation compliance and story outcomes. People engaging in healthy behaviors may experience negative outcomes. The current study utilized social cognitive theory to investigate protagonist self-efficacy (low vs. high) and social comparison self-evaluation as moderators of story outcome (positive vs. negative) with sleep and alcohol topics. A three-way interaction indicated that, for the alcohol narratives, the more participants compared themselves to low self-efficacy, negative ending protagonists (vs. low self-efficacy, positive ending protagonists), the greater their positive change in alcohol self-efficacy.
Early ovariectomy reveals the germline encoding of natural anti-A- and Tn-cross-reactive immunoglobulin M (IgM) arising from developmental O-GalNAc glycosylations. (Germline-encoded natural anti-A-Tn cross-reactive IgM).
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2017
Subjects: subject: Developmental Biology
subject: 60107 Enzymes
subject: FOS: Biological sciences
subject: 60103 Cell Development, Proliferation and Death

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of human “natural” anti-A isoagglutinin production, and metazoan eukaryotic N-acetylgalactosamine O-glycosylation of serine/threonine residues (O-GalNAc-Ser/Thr-R) does not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which is not present in animals that have undergone ovariectomy prior to the onset of puberty. These mammalian ovarian glycolipids are complementary also to the anti-A/Tn cross-reactive Helix pomatia agglutinin (HPA), a molluscan defense protein, emerging from the coat proteins of fertilized eggs and reflecting the snail-intrinsic, reversible O-GalNAc glycosylations. The hexameric structure of this primitive invertebrate defense protein gives rise to speculation regarding an evolutionary relationship to the mammalian nonimmune, anti-A-reactive immunoglobulin M (IgM) molecule. Hypothetically, this molecule obtains its complementarity from the first step of protein glycosylations, initiated by GalNAc via reversible O-linkages to peptides displaying Ser/Thr motifs, whereas the subsequent transferase depletion completes germ cell maturation and cell renewal, associated with loss of glycosidic bonds and release of O-glycan-depleted proteins, such as complementary IgM revealing the structure of the volatilely expressed “lost” glycan carrier through germline Ser residues. Consequently, the evolutionary/developmental first glycosylations of proteins appear metabolically related or identical to that of the mucin-type, potentially “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn (T “nouvelle”) antigen, and explain the anti-Tn cross-reactivity of human innate or “natural” anti-A-specific isoagglutinin and pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo-blood group O. In fact, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur in human blood group O, affecting anti-Tn antibody levels, which may function as a growth regulator that contributes to a potential survival advantage of this group in the overall risk of developing cancer when compared with non-O blood groups.
The Important Role of New Media Literacy (NML) in Vietnam: Adaptation and Validation of the NML Scale
Creators: name: Ho, Huong Thi Ngoc
name: Dinh, Viet Hung
name: Phan, Quang Anh
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: In a world of constant information and immediate communication, new media literacy (NML) is important. Research on NML is essential for many communities worldwide. This study analyzed the NML levels of 614 Vietnamese individuals aged 18 to 71 (M = 30.8, SD = 9.46) using an adapted and validated version of the 35-item NML scale. Linguistic and metrical parity was achieved via exploratory and confirmatory factor analyses, and validation and reliability testing. Results revealed that this new setting was suitable for the adapted scale. Results also indicated that compared to critical literacy, functional literacy is more effective, and that NML is influenced by age, time spent online, and social media profiles.
Supplemental information.docx
Creators: name: Jingxin Mo
Publisher: name: figshare
Year: 2017
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no approved targeted therapy available. A tactfully designed phosphorylated calixarene was used as vehicle to fabricate curcumin-loaded POCA4C6 micelles (CPM) by thin-film method. The morphology of CPM is typical unilamellar structure with an average particle size of 3.86 nm. The high encapsulation efficiency (EE) and drug loading (DL) of CPM were verified by LC-MS/MS. In vitro, our results indicated that CPM could pH-differentially and sustainably release curcumin. Further, CPM could more effectively inhibit human BT-549 breast cancer cells’ proliferation, invasion, migration, and mammospheres formation as well, probably due to cell apoptosis and strong suppression of key signalling proteins of nuclear β-catenin and AR expression. Moreover, after intra-tumoral injection of CPM, CPM could stick to the tumor tissue and substantially contain the growth of xenografted tumor, without noticeable systemic toxicity. Finally, destruction of breast cancer stem cells (BCSCs) was confirmed by significantly reducing CD44+CD133+ expression. Together, our data underline a potential additive effect of curcumin eradicating BCSCs by forming CPM, providing an efficient therapeutic option for anti-TNBC therapy.
FED-AMR Deliverable D4.5 Quantitative results of antibiotics in soil
Creators: name: Gajda Anna
name: Gbylik-Sikorska Malgorzata
name: Brandtner Martin
Publisher: name: Zenodo
Year: 2022
Subjects: FED-AMR
Antibiotics
Soil

description: OHEJP Project: FED-AMR
Literature search: Parameters for CA1 model
Creators: name: McKiernan, Erin
Publisher: name: figshare
Year: 2017
Subjects: Biophysics

description: The purpose of this document is to compile parameters from the published literature on hippocampal CA1 pyramidal cells (PCs). In some cases, where data was not available from CA1 PCs, I included related data (e.g., on ion channel biophysical properties) from other cell types. Some of these parameters will be directly incorporated into a biophysical model of a CA1 PC, while others will be used for fitting the membrane properties and responses of the model. For this project, I am particularly interested in any documented differences between CA1 PCs from young and old animals with respect to these parameters. In addition to informing this study, I hope the information gathered here will also help other researchers wanting to model these cells.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Cart. 181 (11 H 754), 165 folios, f. 0113
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0113, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0113, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Literature search: Parameters for CA1 model
Creators: name: McKiernan, Erin
Publisher: name: figshare
Year: 2017
Subjects: Biophysics

description: The purpose of this document is to compile parameters from the published literature on hippocampal CA1 pyramidal cells (PCs). In some cases, where data was not available from CA1 PCs, we included related data (e.g., on ion channel biophysical properties) from other cell types. Some of these parameters will be directly incorporated into a biophysical model of a CA1 PC, while others will be used for fitting the membrane properties and responses of the model. We are particularly interested in any documented differences between CA1 PCs from young and old animals with respect to these parameters. In addition to informing our studies, we hope the information gathered here will also help other researchers wanting to model these cells.
title: Description of the Larval Development of Squilla empusa Say (Crustacea Stomatopoda) with Aspects of Larval Ecology in Chesapeake Bay
Creators: name: Morgan, Steven Gaines
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 1977

description: Larvae of Sguilla empusa were collected from the plankton and were reared in the laboratory to describe the pelagic larval development and the postlarval stage. Nine pelagic stages are passed through before the postlarval stage is attained.

The larvae reared for descriptive purposes were subjected to sixteen combinations of temperature and salinity to determine their tolerance to the two parameters. Larvae survived longer and molted more frequently when reared at 25°/oo and 20°C or 25°C, which corresponds to the natural conditions of the Chesapeake Bay when the larvae were collected.

A three year planktonic survey conducted in the lower region of the bay by the Virginia Institute of Marine Science was compared to a survey made at the baymouth in 1976. Sguilla empusa larvae appeared in the 1976 survey from the last week of July and persisted until the first week of October with a peak abundance occurring about the first week of September. The peak abundance in the lower region of the bay was 3.6 larvae/m3 in 1971 and 6.3 larvae/m3 in 1972. Four of the nine stages were not captured. Collections taken at the baymouth in 1976 with a half-meter net captured all stages and the peak abundance was determined to be 0.3 larvae/m3. The larvae are distributed throughout the lower Chesapeake Bay without being concentrated in any particular region.
คัมภีร์มิลินทปัญหา: ปริศนาเรื่องกำเนิดและพัฒนาการ
Creators: name: เนาวรัตน์ พันธ์วิไล
Publisher: name: มูลนิธิธรรมะคุ้มครองโลก
Year: 2019
Subjects: มิลินทปัญหา
วัฒนธรรมเฮลเลนิสต์
Origin of Milindapanha
Hellenistic period

description: ธรรมธารา, 5, 2, 177-217
Early ovariectomy reveals the germline encoding of natural anti-A- and Tn-cross-reactive immunoglobulin M (IgM) arising from developmental O-GalNAc glycosylations. (Germline-encoded natural anti-A_Tn cross-reactive IgM) - Arend -.html
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2017
Subjects: subject: Developmental Biology
subject: 60107 Enzymes
subject: FOS: Biological sciences
subject: 60103 Cell Development, Proliferation and Death

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of human “natural” anti-A isoagglutinin production, and metazoan eukaryotic N-acetylgalactosamine O-glycosylation of serine or threonine residues (O-GalNAc-Ser/Thr-R) does not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which is not present in animals that have undergone ovariectomy prior to the onset of puberty. These mammalian ovarian glycolipids are complementary also to the anti-A/Tn cross-reactive Helix pomatia agglutinin (HPA), a molluscan defense protein, emerging from the coat proteins of fertilized eggs and reflecting the snail-intrinsic, reversible O-GalNAc glycosylations. The hexameric structure of this primitive invertebrate defense protein gives rise to speculation regarding an evolutionary relationship to the mammalian nonimmune, anti-A-reactive immunoglobulin M (IgM) molecule. Hypothetically, this molecule obtains its complementarity from the first step of protein glycosylations, initiated by GalNAc via reversible O-linkages to peptides displaying Ser/Thr motifs, whereas the subsequent transferase depletion completes germ cell maturation and cell renewal, associated with loss of glycosidic bonds and release of O-glycan-depleted proteins, such as complementary IgM revealing the structure of the volatilely expressed “lost” glycan carrier through germline Ser residues. Consequently, the evolutionary/developmental first glycosylations of proteins appear metabolically related or identical to that of the mucin-type, potentially “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn (T “nouvelle”) antigen, and explain the anti-Tn cross-reactivity of human innate or “natural” anti-A-specific isoagglutinin and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo-blood group O. In fact, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur in human blood group O, affecting anti-Tn antibody levels, which may function as a growth regulator that contributes to a potential survival advantage of this group in the overall risk of developing cancer when compared with non-O blood groups.
Supplementary Methods and Results/Supplementary Figure from Trunk dental tissue evolved independently from underlying dermal bony plates but is associated with surface bones in living odontode-bearing catfish
Creators: name: Rivera-Rivera, Carlos J.
name: Montoya-Burgos, Juan I.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60310 Plant Systematics and Taxonomy
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60301 Animal Systematics and Taxonomy

description: Details of PCR amplification, cryosection, and timetree inference methods, and a discussion on the relationship between loricarioid diversification rates and lineage divergence times/Maximum Likelihood and Bayesian Inference phylogenies for all four datasets analysed in this study.
Development of arginine-glycine-aspartate-immobilized 3D printed poly(propylene fumarate) scaffolds for cartilage tissue engineering
Creators: name: Ahn, Chi Bum
name: Youngjo Kim
name: Park, Sung Jean
name: Yongsung Hwang
name: Lee, Jin Woo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Poly(propylene fumarate) (PPF) has known to be a good candidate material for cartilage tissue regeneration because of its excellent mechanical properties during its degradation processes. Here, we describe the potential application of PPF-based materials as 3D printing bioinks to create macroporous cell scaffolds using micro-stereolithography. To improve cell-matrix interaction of seeded human chondrocytes within the PPF-based 3D scaffolds, we immobilized arginine-glycine-aspartate (RGD) peptide onto the PPF scaffolds. We also evaluated various cellular behaviors of the seeded chondrocytes using MTS assay, microscopic and histological analyses. The results indicated that PPF-based biocompatible scaffolds with immobilized RGD peptide could effectively support initial adhesion and proliferation of human chondrocytes. Such a 3D bio-printable scaffold can offer an opportunity to promote cartilage tissue regeneration.
Advanced Practice Providers in the Field: Implementation of the Los Angeles Fire Department Advanced Provider Response Unit
Creators: name: Sanko, Stephen
name: Kashani, Saman
name: Ito, Terrance
name: Guggenheim, Aaron
name: Shangnon Fei
name: Eckstein, Marc
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background: To address the growing number of low-acuity patients in the 911-EMS system, the Los Angeles Fire Department (LAFD) launched a pilot program placing an Advanced Provider Response Unit (APRU) in the field so that a prehospital nurse practitioner (NP) could offer patients treatment/release on scene, alternative destination transport, and linkage with social services. Objective: To describe the initial 18-month experience implementing this new APRU. Methods: This is a retrospective, descriptive review of all APRU-attended patients from January 2016 to June 2017. The APRU was an ambulance staffed by an NP and a firefighter/paramedic, equipped with basic point-of-care testing capability, and linked to incidents by either being summoned by on-scene first responders or by monitoring EMS radio traffic. Descriptive statistics were used and outcome measures included counts of clients attended, treat/release rates, impact on total time in service for other LAFD resources, patient need for subsequent re-use of 911 and self-reported experience of care. Results: During its first 18 months in service, the APRU attended 812 patients, including 792 911-patient incidents. 400 of these 911-patients (50.5%) were treated and released on scene or medically cleared and transported to an alternative site for specialty care. This included 76 patients with primary psychiatric complaints who were medically-cleared and transported directly to a mental health urgent care center. An additional 18 high utilizers of 911 were attended by the APRU and connected with a social work organization, and 12 of 18 (66.7%) decreased their use of EMS in the 90-days following APRU evaluation and referral. Of the 400 911-patients that did not go to the emergency department (ED), 26 (6.5%) re-contacted 911 within 3 days: all were transported to the ED with normal vital signs and without prehospital intervention, and all were ultimately discharged home from the ED. As a result of APRU intervention, 458 other LAFD field resources were quickly placed back in service and made available for the next time-critical call. Conclusions: Advanced practice providers such as nurse practitioners can be incorporated into the prehospital setting to address a growing subset of 911-patients whose needs can be met outside of the ED.
Cervical Spine Motion During Vehicle Extrication of Healthy Volunteers
Creators: name: Gabrieli, Alberto
name: Nardello, Francesca
name: Geronazzo, Michele
name: Marchetti, Pierpaolo
name: Liberto, Alessandro
name: Arcozzi, Daniele
name: Polati, Enrico
name: Cesari, Paola
name: Zamparo, Paola
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objective: Prehospital spinal motion restriction as a prevention technique for secondary neurological injury is a key principle in emergency medicine. Our aim was to evaluate the effectiveness of different cervical spinal cord motion restriction techniques of awake and cooperative healthy volunteers during extrication. Methods: Twenty-three healthy volunteers were asked to exit a car (unassisted) with a rigid cervical collar (CC condition) or without it (autonomous exit: AE; instructed exit: IE); they were also extricated by two rescuers after setting a rigid cervical collar and by using an extrication device (CC + XT condition). Eight 3 D infrared cameras were calibrated around the vehicle to measure cervical spine angle, angular speed and acceleration in the sagittal plane. Surface wireless EMG electrodes were used to record superior trapezius, erector spinae and rectus abdominis muscle activity. All measures were recorded during two phases: device positioning (maneuver) and vehicle exiting. Results: The lowest range of motion was observed in CC during maneuver and exit (about 17°), the greatest in AE and IE (about 45°); when the extrication device was utilized along with the cervical collar (CC + XT) an increase, rather than a further decrease, in the range of motion was observed (about 25° during maneuver and exit). Larger values of angular speed and acceleration were observed in CC + XT when compared to CC, both during maneuver and exit (p Conclusions: Our findings support the idea that spinal motion restriction via rigid cervical collar of awake and cooperative trauma patients is effective in reducing cervical spine motion in the sagittal plane during vehicle extrication.
The scoop on brain health dietary supplement products containing huperzine A
Creators: name: Crawford, Cindy
name: Wang, Yan-Hong
name: Bharathi Avula
name: Ji-Yeong Bae
name: Ikhlas A. Khan
name: Deuster, Patricia A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Context: Public health concerns are emerging surrounding huperzine A commonly found in dietary supplements. We sought to determine the actual content of products claiming to contain huperzine A and whether the ingredients on the supplement facts labels matched the analyses. Methods: We identified and analyzed 22 dietary supplement products listing huperzine A on product labels. We found these products were listed in Natural Medicines and Dietary Supplement Databases and being queried by Military Service Members for enhanced mental focus, alertness and energy. Analyses were conducted by using Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry. Results: Sixteen (73%) products had at least one ingredient claimed on the supplement facts label not detected through analysis. Compounds not reported on the label were detected in 16 (73%) products analyzed. Nine products (41%) listed ingredients not meeting the regulations for being a dietary supplement ingredient according to the FDA. Ingredients of most concern detected include stimulants: demelverine, 1,5-dimethylhexylamine, 1,3-dimethylhexylamine, N-phenethyl dimethylamine, halostachine, higenamine, noopept, β-PEA, vinpocetine, sulbutiamine; and hordenine, currently on the FDA advisory list. Quantitative analysis showed the presence of huperzine A in the range from detected under the limits of quantification (DUL) to 267.1 µg/serving. Only two supplements showed huperzine A content within 10% of the declared amount. Conclusions: In a study of dietary supplements claiming to contain huperzine A, we found products that had at least one ingredient claimed on the supplement facts label not detected through analysis. Moreover, some ingredients not on the label could be dangerous and likely do not meet the definition of a dietary supplement ingredient according to the FDA. Quantitative analysis of huperzine A showed the amount detected was not in line with what appeared on the product label. Consumers should be aware of deceptive label claims and warned not to purchase products containing potentially dangerous ingredients.
Advanced Practice Providers in the Field: Implementation of the Los Angeles Fire Department Advanced Provider Response Unit
Creators: name: Sanko, Stephen
name: Kashani, Saman
name: Ito, Terrance
name: Guggenheim, Aaron
name: Shangnon Fei
name: Eckstein, Marc
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background: To address the growing number of low-acuity patients in the 911-EMS system, the Los Angeles Fire Department (LAFD) launched a pilot program placing an Advanced Provider Response Unit (APRU) in the field so that a prehospital nurse practitioner (NP) could offer patients treatment/release on scene, alternative destination transport, and linkage with social services. Objective: To describe the initial 18-month experience implementing this new APRU. Methods: This is a retrospective, descriptive review of all APRU-attended patients from January 2016 – June 2017. The APRU was an ambulance staffed by an NP and a Firefighter/Paramedic, equipped with basic point-of-care testing capability, and linked to incidents by either being summoned by on-scene first responders or by monitoring EMS radio traffic. Descriptive statistics were used and outcome measures included counts of clients attended, treat/release rates, impact on total time in service for other LAFD resources, patient need for subsequent re-use of 911 and self-reported experience of care. Results: During its first 18 months in service, the APRU attended 812 patients, including 792 911-patient incidents. 400 of these 911-patients (50.5%) were treated and released on scene or medically cleared and transported to an alternative site for specialty care. This included 76 patients with primary psychiatric complaints who were medically-cleared and transported directly to a mental health urgent care center. An additional 18 high utilizers of 911 were attended by the APRU and connected with a social work organization, and 12 of 18 (66.7%) decreased their use of EMS in the 90-days following APRU evaluation and referral. Of the 400 911-patietns that did not go to the emergency department (ED), 26 (6.5%) re-contacted 911 within 3 days: all were transported to the ED with normal vital signs and without prehospital intervention, and all were ultimately discharged home from the ED. As a result of APRU intervention, 458 other LAFD field resources were quickly placed back in service and made available for the next time-critical call. Conclusions: Advanced Practice Providers such as nurse practitioners can be incorporated into the prehospital setting to address a growing subset of 911-patients whose needs can be met outside of the ED.
แนวโน้มและพัฒนาการทฤษฎีการกำเนิด ของพระพุทธศาสนามหายาน (1)
Creators: name: พระมหาพงศ์ศักดิ์ ฐานิโย
Publisher: name: มูลนิธิธรรมะคุ้มครองโลก
Year: 2019
Subjects: พัฒนาการ
ต้นกำเนิด
มหายาน
หินยาน
สังฆเภท
prospects
origins
Mahayana
Hinayana
sanghabheda

description: ธรรมธารา, 5, 1, 1-35
Seizure in venlafaxine overdose: a 10-year retrospective review of the California poison control system
Creators: name: Vo, Kathy T.
name: Merriman, Andrew J.
name: Wang, Ralph C.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Medicine
Pharmacology
Biotechnology

description: Background: The optimal observation time period with respect to seizures after venlafaxine overdose is unclear. We conducted a 10-year retrospective review of calls to the California Poison Control System to describe the time of onset of seizures in adult and pediatric overdose of venlafaxine. Methods: Inclusion criteria included adult and pediatric patients with exposure to venlafaxine, who were admitted to a health care facility and who had at least one seizure. We did not exclude cases in which co-ingestions of other drugs were reported. Data extraction of a priori defined variables was recorded. Descriptive statistics were used to characterize the cohort of patients, including means, medians, and interquartile ranges. Results: The total number of cases included in the data analysis was 123 (12.9% of all venlafaxine ingestions). The longest time to last seizure was 24 h. Twenty-five percent of participants had a seizure from hour 7 to 24 h. This did not differ significantly between IR and XR formulations. Conclusions: Optimal observation time with respect to seizures after overdose of immediate-release formulation of venlafaxine is 18 h (24 h if ingested with other medications), and 21 h for patients who are poisoned with the sustained-release formulation.
D3.1 Code for ensemble evaluation in prototype V2
Creators: name: Brasseur P
name: Brankart J.M
name: Popov M
Publisher: name: Zenodo
Year: 2021
Subjects: SEAMLESS
CMEMS
data assimilation
code

description: One of the main objectives of SEAMLESS is to develop innovative open-source based generation and assimilation methods to accelerate the transition of the physical and biological components of CMEMS MFCs to probabilistic systems, with a better ability to provide products with faithful associated uncertainties. The purpose of this document is to introduce Deliverable D3.1, which consists of a toolbox (code) developed to assess the quality and relevance of model-generated ensembles and to provide probabilistic evaluation scores of ensemble assimilation methods. The toolbox is delivered as a code freely available at https://github.com/brankart/ensdam, supplemented by a user’s guide shown in annex of this document. The package has been conceived in order to be easily plugged into existing software (such as the SEAMLESS prototype in WP2) used by all SEAMLESS partners in the frame of the present project, or applicable to ensemble-based CMEMS assimilation systems as well as other external prediction systems (e.g. the OceanPredict community). The user’s guide was written with the objective of presenting the tools in a consistent and “demystified” way in order to facilitate their learning, while avoiding the more complex mathematical formulations and technical details that are otherwise available in the referenced publications (see end of annex).
ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia
Creators: name: Fan, Paroni O. L.
name: Leung, Kam-Tong
name: Chan, Kathy Y. Y.
name: Leung, Alex W. K.
name: Lam, Grace K. S.
name: Chow, Terry T. W.
name: Cheng, Frankie W. T.
name: Yuen, Liz Y. P.
name: Moriyama, Takaya
name: Yang, Jun J.
name: Li, Chi-Kong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Inter-individual variance in 6-mercaptopurine (6-MP) dose intensity is common in patients with acute lymphoblastic leukemia (ALL). We aimed to evaluate the association of common variants of ABCC4, ITPA, NUDT15, and TPMT with 6-MP dose intensity and toxicity in pediatric ALL patients. In this cohort, 13.8% of patients were intolerant to 6-MP with actual dosage less than 50% of scheduled dose. Twenty percent of patients were found to be heterozygous or homozygous mutated with NUDT15. NUDT15 c.415C > T and the genotype-predicted NUDT15 activity were significantly associated with 6-MP intolerance. TPMT*3C variants were not common in this cohort (2.8%). NUDT15 polymorphisms and genotype predicted NUDT15 activity were significantly associated with 6-MP dose intensity and leukopenia episodes. Combination of ABCC4 and ITPA variants (ABCC4 c.912G > T and ITPA c.94C > A) also showed significant positive association with 6-MP intolerance in Chinese children with ALL. Further study on pharmacogenetic screening for ALL patients to avoid 6-MP induced toxicity is recommended. Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.1973628
title: ADCO, Comptes du Petit-Cîteaux (1477-1491) (11 H 1179), f. 00429
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Archives Départementales De La Côte D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Comptes du Petit-Cîteaux (1477-1491), Archives départementales de la Côte-d'Or, (11 H 1179), f. 00429, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Outcome of pediatric germ cell tumor with comparison of carboplatin and cisplatin based regimens: A 10-year analysis
Creators: name: Jain, Richa
name: Menon, Prema
name: Bansal, Deepak
name: Kakkar, Nandita
name: Radhika, Srinivasan
name: Rao, K. L. N.
name: Trehan, Amita
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Carboplatin is being advocated more frequently for treatment of childhood germ cell tumors (GCT), due to less long-term toxicity, and demonstrable equivalence in outcome as compared to cisplatin. This analysis presents the survival of GCT in a low middle-income country and compares two different chemotherapeutic regimens. A retrospective analysis of patient case records was carried out over 10-years (January 2007-December 2016). Chemotherapy regimen used was bleomycin, etoposide, and cisplatin (PEb) for initial 6-½ years and carboplatin, etoposide, and bleomycin (CEb) subsequently. Ninety patients with GCT were treated over 10-years. Malignant GCT was diagnosed in 69 (77%) patients, with 21(23%) having teratoma. The chemotherapy protocol was PEb in 38 (42%), CEb in 28 (31%) patients, while 24 patients were treated with surgery only. Stage 4 tumor was observed in 19 (21%) patients. Relapse or disease progression was seen in 11(12%). Overall and event-free survival at 5-years for the entire cohort was 77% and 73%, being similar with PEb (OS:77%; EFS:72.5%) vs. CEb (OS:69%; EFS: 69%). Significantly better overall survival was noted for patients with gonadal GCT) and non-stage 4 disease, while event-free survival was significantly better in patients with non-stage 4 disease. The chemotherapeutic regimen (PEb vs. CEb), very high AFP (value ≥10,000 IU/L), and risk stratification (low, intermediate, or high-risk disease) did not affect survival significantly. Carboplatin-based strategy was equivalent in our cohort to cisplatin-based strategy, and could be used safely in the LMIC set-up. The overall survival is suboptimal, with delayed presentation, abandonment, and relapse being barriers to survival.
ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia
Creators: name: Fan, Paroni O. L.
name: Leung, Kam-Tong
name: Chan, Kathy Y. Y.
name: Leung, Alex W. K.
name: Lam, Grace K. S.
name: Chow, Terry T. W.
name: Cheng, Frankie W. T.
name: Yuen, Liz Y. P.
name: Moriyama, Takaya
name: Yang, Jun J.
name: Li, Chi-Kong
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Inter-individual variance in 6-mercaptopurine (6-MP) dose intensity is common in patients with acute lymphoblastic leukemia (ALL). We aimed to evaluate the association of common variants of ABCC4, ITPA, NUDT15, and TPMT with 6-MP dose intensity and toxicity in pediatric ALL patients. In this cohort, 13.8% of patients were intolerant to 6-MP with actual dosage less than 50% of scheduled dose. Twenty percent of patients were found to be heterozygous or homozygous mutated with NUDT15. NUDT15 c.415C > T and the genotype-predicted NUDT15 activity were significantly associated with 6-MP intolerance. TPMT*3C variants were not common in this cohort (2.8%). NUDT15 polymorphisms and genotype predicted NUDT15 activity were significantly associated with 6-MP dose intensity and leukopenia episodes. Combination of ABCC4 and ITPA variants (ABCC4 c.912G > T and ITPA c.94C > A) also showed significant positive association with 6-MP intolerance in Chinese children with ALL. Further study on pharmacogenetic screening for ALL patients to avoid 6-MP induced toxicity is recommended. Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.1973628
Development of the dog executive function scale (DEFS) for adult dogs
Creators: name: Foraita, Maike
name: Howell, Tiffani
name: Bennett, Pauleen
Publisher: name: La Trobe
Year: 2022

description: Executive functions (EFs) are cognitive processes that are used to effortfully self-regulate behaviour and might be important for dogs' success in working and pet roles. Currently, studies are assessing dogs' EF skills through often laborious cognitive measures, leading to small sample sizes and lacking measures of reliability. A complementary method is needed. The aim of this study was to develop a dog executive function scale (DEFS) for adult dogs. Focus groups were held with people working with dogs professionally to refine a pool of items describing dog behaviours related to EF. A survey was distributed online to a convenience sample of N = 714 owners of adult dogs. Exploratory and confirmatory factor analysis identified six distinguishable factors named behavioural flexibility, motor inhibition, attention towards owner, instruction following, delay inhibition and working memory. These factors appear similar to factors identified in human EF scales. Working dogs exhibit higher EF scores on the DEFS than non-working dogs. Dogs sourced from breeders exhibited higher DEFS scores than dogs sourced from shelters, and the amount of training received positively correlated with dogs' DEFS scores. The DEFS requires further validation with cognitive measures. The DEFS could then be used by researchers to complement assessment of dogs' EF skills through cognitive measures or assess dogs' EF skills in large samples.
Diverse outcomes in extra-cranial rhabdoid tumors: A single institute experience
Creators: name: Katsumi, Yoshiki
name: Iehara, Tomoko
name: Kuwahara, Yasumichi
name: Tsuchiya, Kunihiko
name: Konishi, Eiichi
name: Hosoi, Hajime
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Rhabdoid tumors (RTs) are a rare and aggressive pediatric cancer that commonly presents with alterations in the tumor suppressor gene SMARCB1. However, RT prognosis is still poor, with no standard treatment available. Moreover, no predictive biomarkers have been identified for determining its aggressiveness or chemo- and radio-sensitivities. Herein, four cases of extra-cranial RTs (ERTs) are described, two of whom are long-term survivors. These two surviving patients were positive for p16, whereas the other two were p16-negative. Our findings suggest that biologically distinct types of ERTs exist and that p16 expression may be a potential positive prognostic biomarker of ERTs. Nevertheless, further studies are required to confirm our findings.
Outcome of pediatric germ cell tumor with comparison of carboplatin and cisplatin based regimens: A 10-year analysis
Creators: name: Jain, Richa
name: Menon, Prema
name: Bansal, Deepak
name: Kakkar, Nandita
name: Radhika, Srinivasan
name: Rao, K. L. N.
name: Trehan, Amita
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Carboplatin is being advocated more frequently for treatment of childhood germ cell tumors (GCT), due to less long-term toxicity, and demonstrable equivalence in outcome as compared to cisplatin. This analysis presents the survival of GCT in a low middle-income country and compares two different chemotherapeutic regimens. A retrospective analysis of patient case records was carried out over 10-years (January 2007-December 2016). Chemotherapy regimen used was bleomycin, etoposide, and cisplatin (PEb) for initial 6-½ years and carboplatin, etoposide, and bleomycin (CEb) subsequently. Ninety patients with GCT were treated over 10-years. Malignant GCT was diagnosed in 69 (77%) patients, with 21(23%) having teratoma. The chemotherapy protocol was PEb in 38 (42%), CEb in 28 (31%) patients, while 24 patients were treated with surgery only. Stage 4 tumor was observed in 19 (21%) patients. Relapse or disease progression was seen in 11(12%). Overall and event-free survival at 5-years for the entire cohort was 77% and 73%, being similar with PEb (OS:77%; EFS:72.5%) vs. CEb (OS:69%; EFS: 69%). Significantly better overall survival was noted for patients with gonadal GCT) and non-stage 4 disease, while event-free survival was significantly better in patients with non-stage 4 disease. The chemotherapeutic regimen (PEb vs. CEb), very high AFP (value ≥10,000 IU/L), and risk stratification (low, intermediate, or high-risk disease) did not affect survival significantly. Carboplatin-based strategy was equivalent in our cohort to cisplatin-based strategy, and could be used safely in the LMIC set-up. The overall survival is suboptimal, with delayed presentation, abandonment, and relapse being barriers to survival.
Development of the dog executive function scale (DEFS) for adult dogs
Creators: name: Foraita, Maike
name: Howell, Tiffani
name: Bennett, Pauleen
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 520499
subject: Cognitive and computational psychology not elsewhere classified
classificationCode: 529999
subject: Other psychology not elsewhere classified

description: Executive functions (EFs) are cognitive processes that are used to effortfully self-regulate behaviour and might be important for dogs' success in working and pet roles. Currently, studies are assessing dogs' EF skills through often laborious cognitive measures, leading to small sample sizes and lacking measures of reliability. A complementary method is needed. The aim of this study was to develop a dog executive function scale (DEFS) for adult dogs. Focus groups were held with people working with dogs professionally to refine a pool of items describing dog behaviours related to EF. A survey was distributed online to a convenience sample of N = 714 owners of adult dogs. Exploratory and confirmatory factor analysis identified six distinguishable factors named behavioural flexibility, motor inhibition, attention towards owner, instruction following, delay inhibition and working memory. These factors appear similar to factors identified in human EF scales. Working dogs exhibit higher EF scores on the DEFS than non-working dogs. Dogs sourced from breeders exhibited higher DEFS scores than dogs sourced from shelters, and the amount of training received positively correlated with dogs' DEFS scores. The DEFS requires further validation with cognitive measures. The DEFS could then be used by researchers to complement assessment of dogs' EF skills through cognitive measures or assess dogs' EF skills in large samples.