cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Transcriptome Assembly of the Bast Fiber Crop, Ramie, Boehmeria nivea (L.) Gaud. (Urticaceae)
Creators: name: Al-Ani, Louay
name: Deyholos, Michael
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Ramie (Boehmeria nivea) is a perennial crop valued for its strong bast fibers. Unlike other major bast fiber crops, ramie fiber processing does not include retting, but does require degumming, suggesting distinctive features in pectin and the development and composition of fibers. A comprehensive transcriptome assembly of ramie has not been made available, to date. We obtained the sequence of RNA transcripts (RNA Seq) from the apical region of developing ramie stems and combined these with reads from public databases for a total of 157,621,051 paired-end reads (30.3 billion base pairs Gbp) used as input for de novo assembly, resulting in 70,721 scaffolds (≥200 base pairs (bp); N₅₀ = 1798 bp). As evidence of the quality of the assembly, 36,535 scaffolds aligned to at least one Arabidopsis protein (BLASTP e-value ≤ 10⁻¹⁰). The resource described here for B. nivea will facilitate an improved understanding of bast fibers, cell wall, and middle lamella development in this and other comparative species.
Storia di Ricerca progetto STEM FOR FUTURE
Creators: name: Zanchin, Martina
name: Raffaghelli, Juliana Elisa
Publisher: name: Zenodo
Year: 2025

description: Nell'ambito del progetto “STEM FOR FUTURE”, nato dalla collaborazione tra l’Università di Padova e CIM&FORM ente di formazione di Confindustria Verona, finanziato dal bando P.A.R.I. della Regione Veneto (DGR n. 1522 del 29/11/2022), sono stati promossi interventi formativi mirati per favorire la parità di genere nelle discipline STEM. Il progetto ha coinvolto studenti e studentesse, lavoratori e lavoratrici, nonché persone in cerca di occupazione, con l’obiettivo di indagare l’impatto della formazione sulla riduzione di stereotipi e sulla modifica degli atteggiamenti di genere.

Questa presentazione ripercorre la storia della ricerca, illustrandone il contesto, gli obiettivi e la metodologia adottata. Nello specifico, vengono approfonditi:

Contesto e motivazione del progetto

Obiettivi della ricerca, strategie e strumenti utilizzati

Domanda di ricerca, focalizzata sull’efficacia degli interventi formativi nel modificare stereotipi di genere

Campione, strumenti di monitoraggio e metodo di ricerca, con dettagli sulle tipologie di formazione, i destinatari e gli strumenti impiegati

Risultati chiave, con implicazioni e significato emerso dall’analisi

Conclusioni e prospettive future, riflettendo sui limiti della ricerca, sulle sfide incontrate e sulle possibili evoluzioni del progetto

La presentazione offre quindi una visione complessiva del percorso svolto, evidenziandone i risultati e le potenzialità per il futuro.

(Link Prezi per una visione dinamica: https://prezi.com/view/Z5E7X2xHRrNqTQqHnZHk/)
title: Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction
title: A Systematic Review
titleType: Subtitle
Creators: name: Maino, Alberto
name: Rosendaal, Frits R.
name: Algra, Ale
name: Peyvandi, Flora
name: Siegerink, Bob
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background and Purpose Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. Methods In this study, we compared the effect of coagulation factors as measures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or <1−SE. Results We identified 70 publications, describing results from 31 study populations, accounting for 351 markers of hypercoagulability. The majority (203/351, 58%) had an RRR greater than 1. A larger effect on IS risk than MI risk (RRE>1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers. Conclusions These results suggest that hypercoagulability has a more pronounced effect on the risk of IS than that of MI.
A state change in the low-mass X-ray binary XSS J12270-4859
Creators: name: Bassa, C. G.
name: Patruno, A.
name: Hessels, J. W. T.
name: Keane, Evan
name: Monard, B.
name: Mahony, E. K.
name: Bogdanov, S.
name: Corbel, S.
name: Edwards, P. G.
name: Archibald, A. M.
name: Janssen, G. H.
name: Stappers, B. W.
name: Tendulkar, S.
Publisher: name: Swinburne
Year: 2024

description: Millisecond radio pulsars acquire their rapid rotation rates through mass and angular momentum transfer in a low-mass X-ray binary system. Recent studies of PSR J1824-2452I and PSR J1023+0038 have observationally demonstrated this link, and they have also shown that such systems can repeatedly transition back-and-forth between the radio millisecond pulsar and low-mass X-ray binary states. This also suggests that a fraction of such systems are not newly born radio millisecond pulsars but are rather suspended in a back-and-forth, stateswitching phase, perhaps for gigayears. XSS J12270-4859 has been previously suggested to be a low-mass X-ray binary, and until recently the only such system to be seen at MeV-GeV energies. We present radio, optical and X-ray observations that offer compelling evidence that XSS J12270-4859 is a low-mass X-ray binary which transitioned to a radiomillisecond pulsar state between 2012 November 14 and December 21. We use optical and X-ray photometry/spectroscopy to show that the system has undergone a sudden dimming and nolonger shows evidence for an accretion disc. The optical observations constrain the orbital period to 6.913±0.002 h.
Calibration of in-situ shape sensing spar
Creators: name: Stansberry, Dustin
Publisher: name: University of Iowa
Year: 2023

description: Shape sensing is a method to reconstruct the deflections experienced by a flexible body [1].Shape sensing is used in many different applications and can be completed with use of iFEM, strain based models, and Digital Image Correlation. Previous work was completed by Di Napoli in the construction and validation of a low cost shape sensing spar. The results of said work were promising but further analysis needs to be conducted before the spar can be used in real world applications. The aim of this work is to validate and calibrate the shape sensing spar so it could be utilized in environments where optical measuring systems would fail, or expensive strain based methods would not be feasible.
description: In this work the strain based method of shape sensing was used and Digital Image Correlation was used to validate the results. The strain gauges are previously implemented in a full-bridge fashion where there are four bending gauges, four torsional gauges, and fastened to a spar made of aluminum. Creating the prescribed motion was done with an extruded aluminum cage incorporating a translational bridge and an encoder equipped rotator. With the spar in a deformed state two high speed cameras were taking pictures and the MultiDIC toolbox was tracking the spar as it deforms. Simultaneously strain measurement were taken, then a kinematic shape sensing model is used to reconstruct the shape of the spar relative to the stain readings. The measurements found with the DIC toolbox are considered a standard to calibrate the strain reconstruction to and strain scaling coefficients are calculated. After the coefficients are found a validation data set is used to quantify the robustness of the new found parameters. Validation is completed with a rigorous uncertainty analysis incorporating errors from the camera calibrations, strain gauge noise, and a confidence interval.
title: Genderfluid identity
title: The role of friendships in the experience, understanding, and expression of fluctuating gender
titleType: Subtitle
Creators: name: Stuart-Maver, Shannon Leigh
Publisher: name: University of Iowa
Year: 2024
Subjects: Friendship
Gender
Genderfluid
Nonbinary
Trans
Transgender
public abstract

description: This study used an interpretative phenomenological approach to examine how genderfluid persons describe the interaction between their gender and friendships. While genderfluid persons have been included in former research, their presence has typically been as a subset of a larger sample of transgender or nonbinary persons, and their qualitative narratives have primarily focused on the description of their gender fluctuations. This study sought to expand understanding of genderfluidity through exploring it in an interpersonal context. Participants in this study were seven individuals who identified as genderfluid and reported recurrent gender fluctuations over time. They engaged in semi-structured interviews focused on exploring gender identity and gender-related experiences in the context of their friendships. Responses were analyzed for shared salient themes across participant responses. Five superordinate themes, along with associated subordinate themes, are presented, discussed, and supported by participant transcript extracts. I highlighted the impact of poor visibility and limited resources for genderfluid persons on participants’ development of self-understanding and their relationships with friends. I emphasized the need for further studies that center genderfluidity and other specific nuanced gender experiences that fall under the larger nonbinary umbrella. Research and clinical implications of results were discussed.
Désir et pouvoir de la critique littéraire québécoise (1960-1980).
Creators: name: Vauterin, Thomas.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Literature, Canadian (French).

description: Cette thèse entend montrer comment s'est opérée, au cours des années 1960 à 1980, la constitution de la subjectivité critique québécoise à travers l'étude des essais de quatre des plus éminents commentateurs du roman québécois: André Belleau, André Brochu, Gilles Marcotte et François Ricard. Bien qu'on puisse facilement, de par le rayonnement médiatique des principaux intéressés, s'en remettre aux personnes réelles pour expliquer la part subjective de leur critique, cette étude se penche plutôt sur la façon dont l'essai a construit cette figure concrète du critique à même sa textualité. Bien plus que par les marques traditionnelles de l'énonciation ou par l'arbitraire du jugement, l'inscription du désir et du pouvoir dans, et à travers, ce discours de savoir nous fait comprendre qu'un texte critique implique une subjectivité. Et c'est dans cet esprit que la présente recherche aura entrepris de mettre à jour les processus de subjectivation. L'examen détaillé du corpus nous révèle donc que la critique du roman québécois s'est constituée comme une discipline professionnelle dans les années 1960 et ce, à travers une série de ruptures qui morcelaient la subjectivité dans ses différents quartiers. Celle-ci était déchirée entre ses désirs littéraires, ses savoirs opérationnels et son pouvoir institutionnel, ce qui laissaient la pratique dans un malaise constant, toujours forcée de se justifier en dehors d'elle-même. Mais au cours des années 1970, il s'est tranquillement effectué des percées dans ces cloisonnements, percées qui ont commencé à laisser couler une écriture dans tous les degrés de textualité. L'essai critique, alors arraché au poids identitaire du roman, a pu devenir producteur de différence dans le champ littéraire. Les derniers textes du corpus laissent d'ailleurs entrevoir comment la critique peut participer à la littérature plutôt que d'en rendre compte de l'extérieur.
Analysis and synthesis of linear sequential machines.
Creators: name: Farley, J. W. Jacques.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1977
Subjects: subject: Engineering, Electronics and Electrical.

description: The material presented in this thesis can be divided into three major topics: Controllability and observability of linear sequential machines, where these principles are presented from the point of view of cyclic subspaces. Such an approach as it pertains to the direct-sum of the state space enables us to extend current results to cases other than the single input and non-derogatory state transition matrix and develop synthesis algorithms for a controllable and/or observable linear sequential machine. Minimality of a linear sequential machine, where these principles are presented from the observability point of view. This approach enables us to develop quick tests for minimality and introduce a different minimization algorithm having definite advantages when dealing with very large machines. This approach then leads us in a natural way to the consideration of minimality where the input sequence length is finite and/or the set of starting states is a subset of the set of states. Shift register synthesis of a linear sequential machine. Our first approach develops an algorithm which yields both parallel and/or serial shift register realizations by mathematically operating upon the characterizing matrices. A generalized synthesis module giving the illusion of variable hardware is presented next. Finally shift register realizations are obtained from the transfer function definition or sets of input/output sequence pairs where the length of the input sequence is finite and starting state restrictions exist.
Innovative Techniques: Best available techniques (BAT) in selected industrial areas
Creators: name: Sander, Knut
name: Wolff, Horst
Publisher: name: Umweltbundesamt
Year: 2014
Subjects: Beste verfügbare Technik

description: Dieser Band des Berichtes fasst Ergebnisse von Emissionsmessungen in Anlagen der Gießerei-Industrie zusammen. Quelle: Forschungsbericht
description: This tome of the report contains a synopsis of the emission measurement results in foundry industry plants. Quelle: Forschungsbericht
Relation entre le point de services, les déterminants de la santé et l'utilisation du test de papanicolaou auprès de femmes autochtones et métis.
Creators: name: Lebeau, Suzanne Lynn.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Obstetrics and Gynecology.

description: Cette étude descriptive vise à explorer les relations entre les déterminants de la santé, les données socio-démographiques et le point de services par rapport à l'utilisation du test Papanicolaou par les femmes autochtones de la région du Nipissing. L'échantillon se compose de 76 femmes autochtones et métis qui ont répondu à un questionnaire oral téléphonique ou face à face. Il y a des relations significatives entre l'utilisation du test Pap, tel que mesuré par la fréquence d'utilisation et le moment du dernier et du prochain test, et les déterminants de la santé et le point de services. Les résultats peuvent servir de tremplin pour des études ultérieures servant à améliorer la planification des soins de santé pour les femmes autochtones.
Two distributed algorithms for finding matchings on a graph.
Creators: name: Yuen, Ching Ki (Simon).
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Computer Science.

description: Two new distributed algorithms for finding matchings on a graph are presented. The first algorithm generates a spanning matching. A spanning matching on a graph is one with respect to which no two adjacent nodes are both free. Starting from any matching, the second algorithm proceeds in phases until a maximum matching is found. In each phase, the algorithm finds at least one augmenting path on the graph with respect to the current matching and then augments the current matching. The algorithm terminates when no more augmenting paths can be found. The main features of our algorithms are the use of multiple virtual alternating trees for finding augmenting paths without using messages for synchronization, "shrinking blossoms" and the labelling. Both algorithms are based on asynchronous networks and assume that only local information is available in each process. Our first algorithm has worst-case communication complexity O(m) and time complexity O(n); and our second algorithm has worst-case communication complexity O(mn) and time complexity O(n$\sp2$), where n is the number of nodes and m is the number of edges of the graph.
Strict Selection Alone of Patients Undergoing Liver Transplantation for Hilar Cholangiocarcinoma Is Associated with Improved Survival
Creators: name: Mantel, Hendrik T. J.
name: Westerkamp, Andrie C.
name: Adam, Rene
name: Bennet, William F.
name: Seehofer, Daniel
name: Settmacher, Utz
name: Sanchez-Bueno, Francisco
name: Prous, Joan Fabregat
name: Boleslawski, Emmanuel
name: Friman, Styrbjorn
name: Porte, Robert J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::617 Chirurgie und verwandte medizinische Einrichtungen

description: Liver transplantation for hilar cholangiocarcinoma (hCCA) has regained attention since the Mayo Clinic reported their favorable results with the use of a neo-adjuvant chemoradiation protocol. However, debate remains whether the success of the protocol should be attributed to the neo-adjuvant therapy or to the strict selection criteria that are being applied. The aim of this study was to investigate the value of patient selection alone on the outcome of liver transplantation for hCCA. In this retrospective study, patients that were transplanted for hCCA between1990 and 2010 in Europe were identified using the European Liver Transplant Registry (ELTR). Twenty-one centers reported 173 patients (69%) of a total of 249 patients in the ELTR. Twenty-six patients were wrongly coded, resulting in a study group of 147 patients. We identified 28 patients (19%) who met the strict selection criteria of the Mayo Clinic protocol, but had not undergone neo-adjuvant chemoradiation therapy. Five–year survival in this subgroup was 59%, which is comparable to patients with pretreatment pathological confirmed hCCA that were transplanted after completion of the chemoradiation protocol at the Mayo Clinic. In conclusion, although the results should be cautiously interpreted, this study suggests that with strict selection alone, improved survival after transplantation can be achieved, approaching the Mayo Clinic experience.
High Levels of Dual-Class Drug Resistance in HIV-Infected Children Failing First-Line Antiretroviral Therapy in Southern Ethiopia
Creators: name: Tadesse, Birkneh Tilahun
name: Kinloch, Natalie N.
name: Baraki, Bemuluyigza
name: Lapointe, Hope R.
name: Cobarrubias, Kyle D.
name: Brockman, Mark A.
name: Brumme, Chanson J.
name: Foster, Byron A.
name: Jerene, Degu
name: Makonnen, Eyasu
name: Aklillu, Eleni
name: Brumme, Zabrina L.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Clinical monitoring of pediatric HIV treatment remains a major challenge in settings where drug resistance genotyping is not routinely available. As a result, our understanding of drug resistance, and its impact on subsequent therapeutic regimens available in these settings, remains limited. We investigate the prevalence and correlates of HIV-1 drug resistance among 94 participants of the Ethiopia Pediatric HIV Cohort failing first-line combination antiretroviral therapy (cART) using dried blood spot-based genotyping. Overall, 81% (73/90) of successfully genotyped participants harbored resistance mutations, including 69% (62/90) who harbored resistance to both Nucleoside Reverse Transcriptase Inhibitors (NRTIs) and Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs). Strikingly, 42% of resistant participants harbored resistance to all four NRTIs recommended for second-line use in this setting, meaning that there are effectively no remaining cART options for these children. Longer cART duration and prior regimen changes were significantly associated with detection of drug resistance mutations. Replicate genotyping increased the breadth of drug resistance detected in 34% of cases, and thus is recommended for consideration when typing from blood spots. Implementation of timely drug resistance testing and access to newer antiretrovirals and drug classes are urgently needed to guide clinical decision-making and improve outcomes for HIV-infected children on first-line cART in Ethiopia.
Cell-specific synaptic plasticity induced by network oscillations
Creators: name: Zarnadze, Shota
name: Baeuerle, Peter
name: Santos-Torres, Julio
name: Boehm, Claudia
name: Schmitz, Dietmar
name: Geiger, Joerg R. P.
name: Dugladze, Tamar
name: Gloveli, Tengis
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Gamma rhythms are known to contribute to the process of memory encoding. However, little is known about the underlying mechanisms at the molecular, cellular and network levels. Using local field potential recording in awake behaving mice and concomitant field potential and whole-cell recordings in slice preparations we found that gamma rhythms lead to activity-dependent modification of hippocampal networks, including alterations in sharp wave- ripple complexes. Network plasticity, expressed as long-lasting increases in sharp wave-associated synaptic currents, exhibits enhanced excitatory synaptic strength in pyramidal cells that is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation. In sharp contrast, alteration of inhibitory synaptic strength is independent of postsynaptic activation and less pronounced. Further, we found a cell type-specific, directionally biased synaptic plasticity of two major types of GABAergic cells, parvalbumin- and cholecystokinin-expressing interneurons. Thus, we propose that gamma frequency oscillations represent a network state that introduces long-lasting synaptic plasticity in a cell-specific manner.
Defense against bacterial toxin secretion systems
Creators: name: Abbasian, Romina
Publisher: name: University of Iowa
Year: 2026

description: The human gut microbiome and soil environments harbor dense, polymicrobial communities where frequent interbacterial interactions and contact-dependent responses occur between community members. Two phyla abundant in these niches, Gram-negative Bacteroidota and Gram-positive Bacillota, utilize contact-dependent type VI and type VII secretion systems (T6SS and T7SS), respectively, to deliver antagonistic toxins (effectors) during competitive encounters with neighboring bacteria. However, the mechanisms of interbacterial antagonism mediated by T6SS and T7SS, as well as proteomic responses to interbacterial contacts, remain underexplored in these ecosystems. Here, we reveal the widespread distribution of the T6SS- DNAse effector (Tde) and its cognate immunity protein (Tdi) amongst gut commensal Bacteroidota species and soil-derived Bacillota species. Structural and functional analyses demonstrate that Tde1 possesses nuclease activity that elicits T6SS-dependent toxicity among Bacteroidaceae strains. Despite sequence differences, the Tde proteins from Bacillota and Bacteroidota phyla exhibited high structural similarities. The crystal structures of isolated Tde and several Tde/Tdi complexes highlight a conserved inactivation mechanism across these two phyla, whereby Tdi immunity proteins bind the effector and disrupt its nuclease fold, except Enterococcus quebeciensis, which displayed slight differences with Tde C-terminus flexibility upon binding to the cognate immunity protein. The Tde/Tdi interaction mode represents a novel mechanism of inactivation distinct from other polymorphic toxin-immunity pairs of known structure. AAA family ATPases in Bacteroides ovatus are downregulated in response to contact with T6SS encoding Bacteroides strains. Deletion of these AAA ATPases alters the response to Tde delivered by T6SS, suggesting roles for these ATPases in responding to T6SS-mediated attack. Our findings reveal that horizontally transferred Tde-encoding T6SS loci confer a competitive advantage to Bacteroidales. The unique Tde/Tdi interaction suggests that Tdi homologs can provide broad immunity by disrupting the conserved Tde fold.
Square moments and bounds for resonance sums of two cusp forms
Creators: name: Samanta, Praneel
Publisher: name: University of Iowa
Year: 2023
Subjects: Automorphic Forms
L-functions
Special Functions
public abstract
Number Theory

description: Let f and g be holomorphic cusp forms for the modular group SL2(Z) of weight k1 and k2 with Fourier coefficients λf (n) and λg(n), respectively. For real $\alpha\neq0$ and $0<\beta\leq1$, consider a smooth resonance sum $S_X(f,g;\alpha,\beta)$ $$ S_X(f, g;\alpha,\beta)
description: := \sum_n \lambda_f(n) \lambda_g(n) e(\alpha n^{\beta}) \phi\Big(\frac nX\Big).$$ Following Iwaniec, Luo, and Sarnak, a general form of Hypothesis S predicts a bound $S_X(f, g;\alpha,\beta)\ll X^{1/2+\varepsilon}$.
description: In this thesis, double square moments of $S_X(f,g;\alpha,\beta)$ over both $f$ and $g$ are nontrivially bounded when their weights $k_1$ and $k_2$ tend to infinity together. By allowing both $f$ and $g$ to move, these double moments are indeed square moments associated with automorphic forms for $GL(4)$. By taking out a small exceptional set of $f$ and $g$, bounds for individual $S_X(f,g;\alpha,\beta)$ shall then be proved. These individual bounds break the resonance barrier of $X^{5/8}$ for $1/6<\beta<1$ and achieve a square-root cancellation for $1/3<\beta<1$ for almost all $f$ and $g$ as an evidence for Hypothesis S.
3620128.pdf
Creators: name: Wigger, Daniel
name: Schneider, Christian
name: Gerhardt, Stefan
name: Kamp, Martin
name: Höfling, Sven
name: Kuhn, Tilmann
name: Kasprzak, Jacek
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental Material
3620128.pdf
Creators: name: Wigger, Daniel
name: Schneider, Christian
name: Gerhardt, Stefan
name: Kamp, Martin
name: Höfling, Sven
name: Kuhn, Tilmann
name: Kasprzak, Jacek
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplemental Material
Inflammatory biomarkers in the eye
Creators: name: Toral, Marcus A
Publisher: name: University of Iowa
Year: 2023
Subjects: subject: Eye Disease
subject: Molecular Medicine
subject: FOS: Basic medicine
subject: Protein Biology
subject: public abstract
subject: Biochemistry
subject: Biomarkers
subject: Ophthalmology

description: Inflammation within the eye (intraocular inflammation) is a major cause of disability and blindness worldwide and is directly or indirectly associated with many eye diseases. However, treatment options for intraocular inflammation are very limited, often relying on imprecise therapies, such as corticosteroid management, with high risks of ocular and systemic side effects with limited effectiveness. These treatment difficulties are reflected in the high cost of medical care for patients suffering from intraocular inflammation, which can be comparable to the costs of cancers, diabetes, and cardiovascular diseases. A poor understanding of the complex and nuanced relationship between the immune system and the eye, particularly at the molecular level, is a major impediment to developing improved, targeted therapies for intraocular inflammation. One powerful approach to address this unmet need is through the careful identification, study, and characterization of protein biomarkers in the eye. The discovery of new inflammatory protein biomarkers in the eye can lead to the development of better, more effective therapeutics to treat intraocular inflammation, as well as improve our understanding of inflammatory disease processes in the eye and elsewhere in the body. In this thesis, I discuss my work aimed at identifying and studying inflammatory protein biomarkers in the eye. In chapter two, I discuss my findings related to a fundamental inflammatory biomarker, the antibody, and demonstrate how the study of intraocular antibodies is important to ongoing human CRISPR/Cas9 gene editing clinical trials in the eye. In chapter three, I broaden my approach to inflammatory protein biomarker identification and characterization, applying proteomics (the large-scale study of proteins) to the inflammatory eye disease Age Related Macular Degeneration. In chapter four, I describe the discovery of the novel CAPN5-IRX3 interaction in the context of inflammatory eye disease and demonstrate how biomarker discovery can be taken a step further through detailed biochemical and mechanistic analyses. My scientific discoveries and contributions described herein improve our understanding of intraocular inflammation and lay the groundwork for better medical care for patients suffering from inflammation within the eye.
The effect of muscle mass and intensity on blood pressure response to isometric exercises in normotensive males.
Creators: name: Faught, Brent E.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Animal Physiology.

description: The purpose of this study was to determine the influence of muscle mass and exercise intensity on blood pressure response to isometric contraction. Twenty male subjects (mean age = 27 yrs) performed one-arm handgrip (HG), one-leg extension (LE) and combined one-arm handgrip plus one-leg extension (COMB) in a random order of exercise for one minute at 30% and 40% of maximal voluntary contraction (MVC). Blood pressure responses were significantly higher (p $$ HG and COMB $>$ LE at both 30% and 40% MVC. However, for each mode of static exercise the hemodynamic responses at 40% MVC were significantly higher than the hemodynamic responses at 30% MVC. There were no significant differences in blood pressure responses between HG and LE within each intensity, except for systolic blood pressure which was significantly greater at 40% MVC than at 30% MVC. Heart rate response increased progressively with increasing size of muscle mass, (COMB $>$ LE $>$ HG) at both intensities. Results indicate that the blood pressure response to static exercise can be attributed in part to the size of the muscle mass being recruited (i.e. COMB) within the same intensity of MVC, and in part to the relative intensity at which the muscle is being contracted. (Abstract shortened by UMI.)
IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca2+ uptake during hypocapnia
Creators: name: Kiefmann, Martina
name: Tank, Sascha
name: Keller, Paula
name: Boernchen, Christian
name: Rinnenthal, Jan L.
name: Tritt, Marc-Oliver
name: Schulte-Uentrop, Leonie
name: Olotu, Cynthia
name: Goetz, Alwin E.
name: Kiefmann, Rainer
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: In adult respiratory distress syndrome (ARDS) pulmonary perfusion failure increases physiologic dead-space (VD/VT) correlating with mortality. High VD/VT results in alveolar hypocapnia, which has been demonstrated to cause edema formation, atelectasis, and surfactant depletion, evoked, at least in part, by apoptosis of alveolar epithelial cells (AEC). However, the mechanism underlying the hypocapnia-induced AEC apoptosis is unknown. Here, using fluorescent live-cell imaging of cultured AEC type 2 we could show that in terms of CO2 sensing the tricarboxylic acid cycle enzyme isocitrate dehydrogenase (IDH) 3 seems to be an important player because hypocapnia resulted independently from pH in an elevation of IDH3 activity and subsequently in an increase of NADH, the substrate of the respiratory chain. As a consequence, the mitochondrial transmembrane potential (ΔΨ) rose causing a Ca2+ shift from cytosol into mitochondria, whereas the IDH3 knockdown inhibited these responses. Furthermore, the hypocapnia-induced mitochondrial Ca2+ uptake resulted in reactive oxygen species (ROS) production, and both the mitochondrial Ca2+ uptake and ROS production induced apoptosis. Accordingly, we provide evidence that in AEC type 2 hypocapnia induces elevation of IDH3 activity leading to apoptosis. This finding might give new insight into the pathogenesis of ARDS and may help to develop novel strategies to reduce tissue injury in ARDS.
Wittgenstein's critique of the logicist definition of number in the "Tractatus Logico-Philosophicus"
Creators: name: Mulvihill, Corey
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Philosophy.

description: The goal of this thesis is to present a coherent and exhaustive picture of Wittgenstein's critique of the logicist definition of number as presented by his philosophy of mathematics in the Tractatus Logico-Philosophicus . It does so by considering several critiques that Wittgenstein makes of the logicist's definition of number. Furthermore, this thesis compares Wittgenstein's operational definition of number---the central feature of Wittgenstein's theory---to Church's lambda calculus to demonstrate how Wittgenstein has a similar understanding of arithmetic.
Analyse de réseaux et intégration d'une approche déductive aux systèmes d'information géographique : l'exemple du transport routier des matières dangereuses.
Creators: name: Leroux, Denis G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Geography.

description: The main topic of this thesis is transportation geography and more specifically the problem of safe path finding for the transportation of dangerous goods. Most of the path finding algorithms use impedance as a unique variable for optimisation. This approach is limited, especially in the domain of dangerous goods, where quantitative and qualitative variables must be considered when selecting a path. This research shows that decision theory and expert systems are among the best tools to make conventional path finding algorithms more flexible and able to deal with quantitative and qualitative data. A path finding model based on the coupling of the Dijkstra algorithm and an expert system has been developed in this thesis. The integration of this model to a geographic information system creates a spatial decision support system for the transportation of dangerous goods. Formalisation of the safe path finding model and development of the decision support system are demonstrated by an example of the Ottawa-Hull area.
Optical ultrafast characterization of copper oxide (CuO) nanocrystal charge-carrier dynamics
Creators: name: Hristovski, Ilija
name: Born, Brandon
name: Krupa, Jeffrey
name: Holzman, Jonathan
Publisher: name: SPIE
Year: 2021

description: A thorough investigation of copper oxide, specifically cupric oxide (CuO), is performed in the following work with a focus on CuO’s ultrafast free-carrier dynamics and bandstructure. An above-bandgap control beam and below-bandgap signal beam are utilized in transient absorption spectroscopy to gain insight on CuO nanocrystals’ recombination and relaxation dynamics at varying control beam fluences. The authors witnessed three distinct time constants, the first of which changed with control beam fluence between 330 and 630 fs, while the second and third remained constant at 2 ps and 50 ps, respectively. The first time constant is attributed to momentum relaxation from valence band carrier-carrier scattering and exciton-exciton annihilation. The second time constant is attributed to energy relaxation from valence band carrier-phonon scattering. The third time constant is attributed to trapping and recombination as a result of the CuO nanocrystals’ increased trap state density. The findings of this work provide a basis for future research on this emerging CuO nanocrystal system
Wheel of fortune
Creators: name: Zhang, Geng
Publisher: name: University of Iowa
Year: 2023
Subjects: Full Orchestra
Orchestra

description: This orchestral work draws inspiration from the Wheel of Fortune, card number ten of the Tarot's Major Arcana. The card features a large wheel engraved with mystical symbols and is encircled by three mythological figures representing death, rebirth, and challenge. Additionally, four animals embody both the four zodiac signs and the fundamental elements of the material world: air, fire, water, and earth. The card reflects the mysteries of the cosmos, the unpredictability of human destiny, and the critical importance of using one's wisdom to navigate the ever-changing world. The piece aims to express an understanding and contemplation of the card's meanings, from the surface to the deeper layers, using distinct themes, a palette of rich timbres, and a clear sectional structure.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Creators: name: Schuette, Moritz
name: Risch, Thomas
name: Abdavi-Azar, Nilofar
name: Boehnke, Karsten
name: Schumacher, Dirk
name: Keil, Marlen
name: Yildirimman, Reha
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I–IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.
title: The practice of a sketchbook
title: a curriculum
titleType: Subtitle
Creators: name: David, Monica J.
Publisher: name: University of Iowa
Year: 2023
Subjects: Arts-Based Research
Curriculum
Metacognition
Sketchbook
public abstract
Curriculum Development
Drawing

description: Sketchbooks are the record of a lived experience through the eyes of a visual thinker, the record of a life lived. Scholars, artists, and educators all define sketchbooks differently, such as journals, diaries, field notebooks, study books, and portfolios. In my research, I ask, what is the significance of a sketchbook in an artist’s practice and how can sketchbooks be used in a high school visual arts classroom? I did extensive reading on metacognition, artist’s sketchbooks, and art curricula providing a literature review that shows how sketchbooks reveal thinking and connection, encourage creativity, contain observations of the world through drawing, and enhance personal character. I used arts-based research as my method to develop the habit of a sketchbook in my own artistic practice. I analyzed my process, pages, and experiences to design a nine-week visual art curriculum that has visual art students developing their habit of a sketchbook using backward curriculum design planning. The curriculum includes drawing exercises, media exploration/demonstrations, creative constraints, art history/sketchbook samples, and gallery activities. A pacing chart is used to demonstrate the practical application of the unit in the classroom. Sketchbooks are an essential tool in the visual art classroom that encourages creativity, enhances personal character, and develops metacognition in students.
La narrativité au cinéma : une étude du mythe de Faust.
Creators: name: Mathur, Chandrika.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Cinema.

description: Le point focal de cette these sera ce recit particulier qu resulte de l'interaction du caractere polyvalent du cinematographe et des contraintes que ce medium impose. Des ses debuts, le septieme art a largement emprunte a des traditions litteraries, theatrales, musicales, et picturales, mais s'est forge petit a petit sa propre tradition narrative en adaptant celles-la a sa specificite spatio-temporelle, ethique et cognitive. Le contenu ainsi que la forme, les articulations, et les enjeux de ce recit "polyphonique" (au sens concret) du film constitueront le corps de notre interrogration sur la narrativite cinematographique. Etudier la narrativite reviendra donc a tenter de degager les articulations principales de cette succession d'etats et de transformations. Nous tacherons de demontrer comment et dans quelle mesure la specificite technique et esthetique du cinema, ainsi que les conditions de reception du film determinent les structures narratives propres a celui-ci, privilegient certaines peripeties au detriment des autres, imposent le choix de certains themes plutot que d'autres. En effet rien au cinema ne "va de soi" alors qu'en regardant un film le spectateur a souvent l'impression d'etre en presence d'un monde tout a fait naturel voire "reel". Demystifier ce "naturel" du recit cinematographique, devoiler son intentionnalite--c'est a dire les choix narratifs de contenu et de forme, analyser ses fondements specifiques en rapport avec la visee esthetique et ideologique de son realisateur est la tache que nous nous proposons de faire dans cette these sur la narrativite au cinema. Et ceci contribuera, a notre avis, a l'epistemologie generale de la specificite du mode narratif au cinema. C'est la "forme du recit" qui nous interesse. Aussi avons-nous cru pertinent d'avoir un corpus continu, qui, tout en presentant une thematique commune et une base de peripeties comparables, permettrait de voir un echantillon important des variantes narratives d'une seule problematique tant au niveau de succession de peripeties qu'au niveau de formes dont celles-ci peuvent se revetir. C'est dans cette perspective que nous avons choisi le mythe de Faust comme theme reliant les films de notre corpus. (Abstract shortened by UMI.)
In vitro activity of immunosuppressive drugs against Plasmodium falciparum
Creators: name: Veletzky, Luzia
name: Rehman, Khalid
name: Lingscheid, Tilman
name: Poeppl, Wolfgang
name: Burgmann, Heinz
name: Ramharter, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background Solid organ transplant recipients are particularly vulnerable for infectious diseases due to prolonged immunosuppressive treatment. Residents of endemic regions and travellers may be exposed to malaria and may, therefore, require prolonged antimalarial chemoprophylaxis. The hypothesis of this study was that certain immunosuppressive drugs may exert clinically relevant anti- malarial activity. It was therefore designed to assess the intrinsic anti- malarial activity of everolimus, mycophenolic acid, and rapamycin against Plasmodium falciparum in an in vitro model. Methods Three laboratory adapted clones of P. falciparum and two isolates were used to assess the potential of mycophenolic acid, rapamycin and everolimus to inhibit in vitro growth of P. falciparum. The standard histidine rich protein 2 assay was employed and inhibitory drug concentrations (IC) were computed by non-linear regression analysis. Results All drugs were associated with complete inhibition of P. falciparum growth in in vitro assays. Mycophenolic acid demonstrated IC50 and IC90 values of 5.4 μmol/L and 15.3 μmol/L. Rapamycin inhibited P. falciparum growth at 7.2 μmol/L (IC50) and 12.5 μmol/L (IC90), respectively. Finally, everolimus displayed IC50 and IC90 values of 6.2 μmol/L and 11.5 μmol/L. There was no difference in in vitro activity against chloroquine sensitive or chloroquine resistant parasites. Conclusions All immunosuppressive drugs evaluated in this in vitro study demonstrated activity against P. falciparum. Inhibitory concentrations of mycophenolic acid are within clinically achievable plasma concentrations when used in solid organ transplant recipients. Further in vivo evaluation of mycophenolic acid either alone or in combination regimens may prove promising for the concomitant prevention of P. falciparum in solid organ transplant recipients living or travelling in malaria endemic regions.
title: Design evolution
title: navigating from organic to geometric in artistic exploration
titleType: Subtitle
Creators: name: Freeman, Katie
Publisher: name: University of Iowa
Year: 2024
Subjects: design
form
function
geometric
organic

description: In this master's thesis, I embark on a transformative design journey marked by a profound exploration of the intricate interplay between organic and geometric forms. Initiated by the constraints and requirements of specific design projects, the narrative unfolds as I navigate the challenges of transitioning from my organic design roots to the embrace of angular and geometric shapes. Focused on reconciling the limitations imposed by specific materials and manufacturing processes, my research takes a multi-faceted approach.
description: The investigation begins with an exploration of geometric shapes in nature, delving into curved and segmented forms inspired by creatures like crustaceans and pill bugs. These discoveries transcend mere inspiration, becoming practical solutions to the design challenges encountered during this transitional period. Model making emerges as a crucial tool, guiding me through constraints and unveiling the potential of new materials and processes.
description: As the journey unfolds, my research expands to encompass various elements of the design process, including a study of designers from the past and present, diverse materials, manufacturing processes, and the integration of architectural principles in furniture design. This holistic exploration culminates in a deeper understanding of the evolution from an organic design inclination to a profound fascination with geometric forms. From zoomed-in molecular structures to the final pages, the thesis encapsulates the twists and turns of this exploration, demonstrating the symbiosis between nature's organic beauty and the structured realm of design.