cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identifying multimorbid patients with high care needs - A study based on electronic medical record data
Creators: name: Heins, Marianne
name: Korevaar, Joke
name: Francois Schellevis
name: Rijken, Mieke
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Patients with multimorbidity who frequently contact the general practice, use emergency care or have unplanned hospitalisations, may benefit from a proactive integrated care intervention. General practitioners are not always aware of who these ‘high need’ patients are. Electronic medical records are a potential source to identify them. To find predictors of high care needs in general practice electronic medical records of patients with multimorbidity and assess their predictive value. General practice electronic medical records of 245,065 patients with ≥2 chronic diseases were linked to hospital claims data. Probit regression analysis was conducted to predict i) having at least 12 general practice contacts per year, ii) emergency department visit(s), and iii) unplanned hospitalisation(s). Predictors were patients’ age, sex, morbidity, health services and medication use in the previous year. 11% of multimorbid patients had ≥12 general practice contacts, which could be reliably predicted by the number of contacts in the previous year (PPV 42%). The model containing all predictors had only slightly better predictive value (PPV 44%). Emergency department visits and unplanned hospitalisations (12% and 7% of multimorbid patients, respectively) could be predicted less accurately (PPV 27% and 20%). Those with frequent contact with the general practice hardly overlapped with ED visitors (29%) or persons with unplanned hospitalisations (17%). Among multimorbid populations various ‘high need’ groups exist. Patients with high needs for general practice care can be identified by their previous use of general practice care. To identify frequent ED visitors and persons with unplanned hospitalisations, additional information is needed.
title: Action Plan "Digitalization of the Swiss Geological Subsurface" 2022 - 2029
Creators: name: Baumberger, Roland
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
A coordinated and effective use of the subsurface requires in-depth knowledge and easily accessible and uniformly described data. The 2022 Action Plan supports the securing of future investments in the subsurface through the provision of structured and harmonized digital geological data.

The efficient use of geological data in Switzerland is hindered by these factors: 1) Existing data sets are neither completely available in digital form, nor comprehensive, nor harmonized; 2) Uniform access to federal and cantonal data is lacking; 3) Information systems for 3D visualization and analysis of geological and non-specialist (geo-referenced) data are being developed.

In the future, the main benefit of geoinformation will be generated from the improvement of efficiency in the processing of existing data and from increased data quality, not from new products. The action plan starts here and defines these fields of action: Standards, Harmonization, Production and Access. In doing so, it is aligned with various strategies and policy areas. The digitalization called for in the action plan will facilitate the exchange and use of geological data and improve their availability. A coordinated approach with the most important national data owners is in focus, as is the use of new technologies.

The success of the action plan will be measured after completion by the state of digitization of analog archives as well as the achieved standardization, harmonization and completion of geological data and models throughout Switzerland.

The presentation will highlight the background, scope, ongoing implementation and future of the action plan using practical examples.
title: A large regional structure from puzzle pieces - Gulf of Mexico structures on the western flank of the Eichsfeld-Altmark-Swell (EAS)?
Creators: name: Malz, Alexander
name: Kley, Jonas
name: Röhling, Heinz-Gerd
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
We discuss the structures associated with the Eichsfeld-Altmark-Swell (EAS) in Central Germany, using observations from published cross-sections, outcrops, few boreholes and reflection seismics in a some 200 kilometres long swath in Central Germany. The EAS is well-documented as an approximately NNE-SSW-trending Permo-Triassic intrabasinal high, expressed by reduced thickness, facies changes and unconformities. It was accompanied by depocenters trending parallel to its axis, which changed in position and magnitude during geologic epochs. North of the Harz Mountains an approximately 10 km wide strip of the EAS´s western flank is strongly structured by faults of the Braunschweig-Gifhorn-Fault Zone (BGFZ). There, local thickness reductions of several hundred meters, in places culminating in complete absence of Lower and Middle Buntsandstein and apparently often associated with salt tectonics, are documented by seismics and well data, contrasting with the regional thickness reductions in the range of tens of meters typically attributed to the EAS. In Keuper time areas with large Buntsandstein hiatuses turned into depocenters. The spatial relationships of these depocenters with bordering normal faults and associated salt structures indicate that the western flank of the EAS was influenced by strong extension (up to 5 km) along low-angle normal faults detaching in Zechstein evaporites. No prominent basement offsets are observed, although they become prominent along trend of the BGFZ in the aligned westward terminations of the Flechtingen High, Harz and Thuringian Forest basement blocks. We discuss solutions for the mismatch of strong thin-skinned extension and apparently little deformed basement.
title: The World Heat Flow Database project: a new research data infrastructure for a community-driven Global Heat Flow Database
Creators: name: Fuchs, Sven
name: Norden, Ben
name: Neumann, Florian
name: Elger, Kirsten
name: Jennings, Sam
name: Frenzel, Simone
name: Ott, Nickolas
name: Maes, Stephan
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The Global Heat Flow Database (GHFDB) is fostered and maintained by the International Heat Flow Commission (IHFC) for nearly 60 years. During these decades, the technological database concepts and storing capabilities evolved, allowing to add entries in the heat-flow database and underlying scientific methods according to the state of the art and database technology. In 2019, a collaborative database revision process started to provide a quality-assured and authenticated database. The community-driven approach, called the Global Heat Flow Data Assessment Project, started with a discussion of a new database structure to substitute the former database structure from 1976. It was designed to scrutinize and reassess the stored heat flow data according to the new structure. In parallel, the DFG-funded World Heat Flow Database project is developing a modern research data infrastructure for the new global compilation of heat flow data. It will offer comprehensive information on heat-flow related data, publications, projects, and researchers. It is designed to reflect the criteria of FAIR and OPEN data policy and to support the interoperability with other geoscientific data services
First Observation of an Acetate Switch in a Methanogenic Autotroph ( Methanococcus maripaludis S2)
Creators: name: Vo, Chi Hung
name: Goyal, Nishu
name: Karimi, Iftekhar A
name: Kraft, Markus
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original Research
acetate switch
acetate dissimilation
acetate assimilation
Methanococcus maripaludis
ADP-forming acetyl-CoA synthetase
Acd

description: The transition from acetate production by a microorganism in its early growth phase to acetate re-uptake in its late growth phase has been termed acetate switch. It has been observed in several heterotrophic prokaryotes, but not in an autotroph. Furthermore, all reports hitherto have involved the tricarboxylic acid cycle. This study reports the first observation of acetate switch in a methanogenic autotroph Methanococcus maripaludis S2, which uses the Wolfe cycle for its anaerobic respiration. When grown in minimal medium with carbon dioxide as the sole carbon source, and either ammonium or dinitrogen as the sole nitrogen source, M. maripaludis S2 dissimilated acetate in the early growth phase and assimilated it back in the late growth phase. The acetate switch was more pronounced in the dinitrogen-grown cultures. We postulate that the acetate dissimilation in M. maripaludis S2 may serve as a metabolic outlet for the carbon overflow in the early growth phase, and the assimilation in the late growth phase may be due to the scarcity of the carbon source. Based on the primary and secondary protein structures, we propose that MMP0253 may function as the adenosine diphosphate (ADP)-forming acetyl-CoA synthetase to catalyse acetate formation from acetyl-CoA. To verify this, we produced MMP0253 via the ligation-independent cloning technique in Escherichia coli strain Rosetta (DE3) using pNIC28-Bsa4 as the vector. The recombinant protein showed catalytic activity, when added into a mixture of acetyl-CoA, ADP, and inorganic phosphate (Pi). The concentration profile of acetate, together with the enzymatic activity of MMP0253, shows that M. maripaludis S2 can produce acetate and exhibit an acetate switch.
Bregman generalized subgradient projected algorithms and applications
Creators: name: Mao, Xiaoyu
Publisher: name: University of British Columbia
Year: 2023

description: Projected subgradient methods were thought as ideal algorithms for constrained minimization problems. But they are often hampered by the computational complexity of the projection operator. The generalized Bregman distance has been identified as a potential solution to this issue. This thesis delves into an in-depth analysis and conducts numerical experiments on projected subgradient methods that utilize Bregman distances. Firstly, we discuss the existing mirror descent algorithm, which is designed for one-block constrained minimization problems. Previous research has revealed its equivalence with Bregman projected subgradient method. Subsequently, we expand this algorithm to accommodate two-block situations, thereby increasing its applicability. We also provide its convergence proof. Our algorithm has a strong correlation with another renowned method, the "proximal alternating linearized method," which can be considered a specific variant of our approach. In the numerical experiments, we choose a variety of examples from various fields, such as matrix analysis and statistics. The data we used are derived from both artificial and real-world sources. The results consistently indicate that Bregman generalized algorithms significantly reduce computation time, particularly when the variable is constrained to the unit simplex. This further corroborates our hypothesis that Bregman distances enhance the performance of projected subgradient methods.
Recapitulation of polymicrobial communities associated with cystic fibrosis airway infections: a perspective
Creators: name: O'Brien, Thomas J
name: Welch, Martin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Perspective
coculture
cystic fibrosis
in silico
in vitro
in vivo
infection model
interspecies interactions
microbiology
polymicrobial

description: The airways of persons with cystic fibrosis are prone to infection by a diverse and dynamic polymicrobial consortium. Currently, no models exist that permit recapitulation of this consortium within the laboratory. Such microbial ecosystems likely have a network of interspecies interactions, serving to modulate metabolic pathways and impact upon disease severity. The contribution of less abundant/fastidious microbial species on this cross-talk has often been neglected due to lack of experimental tractability. Here, we critically assess the existing models for studying polymicrobial infections. Particular attention is paid to 3Rs-compliant in vitro and in silico infection models, offering significant advantages over mammalian infection models. We outline why these models will likely become the ‘go to’ approaches when recapitulating polymicrobial cystic fibrosis infection.
title: Hyperspectral airborne and satellite data from EnMAP for mineral mapping of raw material at Gamsberg-Aggeneys area, South Africa
Creators: name: Schodlok, Martin C.
name: Frei, Michaela
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Hyperspectral remote sensing already is important in geoscientific research in the fields of geology, soil, exploration and mining. New hyperspectral satellite systems are already in operation (e.g. EnMAP, PRISMA and DESIS) and more systems are planned e.g. the European Copernicus Next Generation Hyperspectral Satellite CHIME. Investigated are the information contents of hyperspectral data for exploration target recognition and their dependency on spatial resolutions of different sensor platforms. Airborne data offer high spatial resolution of 2.5 m with limited areal data acquisition, whereas hyperspectral spaceborne sensors guaranty nearly worldwide data availability with the same spectral characteristics but medium spatial resolution (30 m). The aspects of high spectral resolution and high versus medium spatial resolution targeted mineral mapping is demonstrated. Hyperspectral satellite data are analyzed successfully to map major mineralogy and proxy minerals such as hematite for the ore mineralization at Gamsberg. The results indicate, that hyperspectral satellite data are an important data source for exploration activities despite the moderate spatial resolution. However, for detailed mapping especially within a mineralization zone, hyperspectral high spatial resolution data from airborne or unmanned aerial vehicle (UAV) systems are important, to understand and to map the mineralogy of such a zone in their complete complexity.
Multicentric breast cancer with heterogeneous histopathology: a multidisciplinary review
Creators: name: Corso, Giovanni
name: Magnoni, Francesca
name: Provenzano, Elena
name: Girardi, Antonia
name: Iorfida, Monica
name: De Scalzi, Alessandra Margherita
name: Invento, Alessandra
name: Colleoni, Marco
name: Cassano, Enrico
name: Trentin, Chiara
name: Gullo, Roberto Lo
name: Pravettoni, Gabriella
name: Gilardi, Laura
name: Grana, Chiara Maria
name: Intra, Mattia
name: Galimberti, Viviana
name: Veronesi, Paolo
name: Lorenzi, Francesca De
name: Leonardi, Maria Cristina
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Review
breast cancer
breast cancer histotypes
diagnosis
lobular carcinoma
multicentric cancer
multidisciplinary team
multifocal cancer
prognosis
surgical management

description: Multiple synchronous (multifocal or multicentric) ipsilateral breast cancers with heterogeneous histopathology are a rare clinical occurrence, however, their incidence is increasing due to the use of MRI for breast cancer screening and staging. Some studies have demonstrated poorer clinical outcomes for this pattern of breast cancer, but there is no evidence to guide clinical practice. In this multidisciplinary review, we reflect on pathology and molecular characteristics, imaging findings, surgical management including conservation and reconstructive options and approach to the axilla, and the role of chemotherapy and radiotherapy. Multidisciplinary discussions appear decisive in planning an appropriate surgical choice and defining the correct systemic treatment tailored to each clinical condition.
title: Slags from DRI-EAF steel making – a case study on upcoming by-products from the decarbonized steel industry
Creators: name: Gronen, Lars Hans
name: Demond, Derik
name: Pflaeging, Dirk
name: Algermissen, David
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Due to the Green Deal proposed by the European Union, several industry sectors in Europe are forced to change the production techniques towards a zero-carbon dioxide emission until 2050. For the steel industry the substitution of fossil fuel, used in the blast furnace (BF), by hydrogen as reduction agent relates to the introduction of new technologies and aggregates. Nowadays, only a small amount of shaft furnaces using natural gas for reduction of iron ores to produce direct reduced iron (DRI). However, this combination is one of the favoured future hydrogen operated routes of alternative steel making in the European Union. The crude steel is, thereby, produced from solid DRI together with scrap molten within the electric arc furnace (EAF). Thus, the minor and trace element composition of the produced EAF slags is directly inherited from the input materials because no density driven phases separation takes place in the DRI which is one major difference to the traditional BF route.

Here we present the results of mineralogical, chemical as well as construction technological investigations carried out on one exemplary slag from the EAF route were app. 2/3 of the input material was sponge iron. The main emphasis of the presented study lies on the ongoing applicability of the EAF slags produced in the future as secondary product in the context of steel industry feature the planned reduction of carbon dioxide emissions.
LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism
Creators: name: Pucci, Perla
name: Venalainen, Erik
name: Alborelli, Ilaria
name: Quagliata, Luca
name: Hawkes, Cheryl
name: Mather, Rebecca
name: Romero, Ignacio
name: Rigas, Sushilaben H
name: Wang, Yuzhuo
name: Crea, Francesco
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
BCL2A1
castration-resistant prostate cancer
drug resistance
HORAS5
lncRNA

description: Background: Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. Materials & methods: LncRNA HORAS5 role in cabazitaxel resistance (i.e., cell-count, IC50 and caspase activity) was studied via lentiviral-mediated overexpression and siRNA-based knockdown. Genes expression was analyzed with RNA-sequencing, reverse transcription quantitative PCR (RT-qPCR) and western blot. HORAS5 expression was queried in clinical database. Results: Cabazitaxel increased HORAS5 expression that upregulated BCL2A1, thereby protecting CRPC cells from cabazitaxel-induced apoptosis. BCL2A1 knockdown decreased cell-count and increased apoptosis in CRPC cells. HORAS5-targeting antisense oligonucleotide decreased cabazitaxel IC50. In CRPC clinical samples, HORAS5 expression increased upon taxane treatment. Conclusion: HORAS5 stimulates the expression of BCL2A1 thereby decreasing apoptosis and enhancing cabazitaxel resistance in CRPC cells.
title: Medical Image Segmentation Through Deep Learning on Companion Animal Thoracic Radiographs and MR Scans of the Human Brain
Creators: name: Tahghighi, Peyman
Publisher: name: Schulich School of Engineering
Year: 2025
Subjects: subject: Veterinary Radiographs
subject: Magnetic Resonance Imaging
subject: Machine Learning
subject: Deep Learning
subject: Engineering

description: Image segmentation involves precisely delineating pixels in 2D images or voxels in 3D images. This task plays a critical role in medical image analysis by enabling the isolation of essential structures for diagnosis. However, manual segmentation is labour-intensive, making automation indispensable. Medical image segmentation can be applied to single-time-point images, where a single image is analyzed, or multi-time-point images, where segmentation identifies changes between baseline and follow-up images. This thesis investigates medical image segmentation in both contexts, specifically in (1) quality assessment of 2D thoracic radiographs in companion animals and (2) segmentation of 3D Magnetic Resonance Imaging (MRI) scans for detecting new brain white matter lesions in Multiple Sclerosis (MS) patients between baseline and follow-up MRI scans. Thoracic radiographs are essential for diagnosing canine patients, but small animal practices often face acquisition errors that hinder interpretation. This research aims to develop an automated method for detecting acquisition errors in radiographs. Existing approaches for radiograph quality assessment primarily rely on deep learning models, which are prone to overfitting due to the limited dataset size. To overcome these challenges, our approach integrates domain expertise with machine learning by segmenting key anatomical structures and extracting expert-relevant features. Experimental results demonstrate that this segmentation-based feature extraction approach outperforms fully deep learning methods regarding classification accuracy, offering improved generalizability. Medical image segmentation also extends to 3D biomedical images, which consist of stacks of 2D slices. Here, we focus on detecting white matter lesions in MS patients. MS is an inflammatory disease that disrupts nerve communication, with MRI lesions serving as key biomarkers for diagnosis and monitoring. However, manual delineation of these lesions is time-consuming, necessitating automated approaches. To enhance the performance of new lesion segmentation models, we propose a self-supervised pretraining scheme based on image inpainting and synthetic lesion augmentation to increase the variability of samples our model is exposed to during training. Experiments conducted on the MSSEG-2 dataset demonstrate that our pretraining method can outperform common techniques such as contrastive learning and the addition of synthetic lesions, resulting in improved segmentation performance.
Kavim
Creators: name: Şentürk, Recep
Publisher: name: Zenodo
Year: 2002
Subjects: Kavim
Hadis
Kur'an-ı Kerim
Amel

description: Sözlükte "aynı soydan gelen, töre, dil ve kültürleri bir olan insan topluluğu" anlamına gelen kavim (kavim) "ırk, millet" manasında da kullanılır. Yeni bir kavram olan kavmiyye de (kavmiyetçilik) "milliyetçilik milliyetçilik, ırkçılık" anlamındadır. Arap dilcileri, kavim kelimesini genellikle tekili olmayan t opluluk ismi olarak değerlendirmişlerdir. Bunun çoğulu akvam, çoğulunun çoğulu ekavim, ekavlm ve ekayimdir. Kelimenin nadiren "nisa" (kadınlar) karşıtı olarak yalnız erkekler için kullanıldığı ol muşsa da umumiyetle erkek ve kadınlardan oluşan topluluğu ifade eder; nitekim Kur'an-ı Kerim'de her iki şekilde de, yani hem müzekker hem müennes olarak yer almıştır. Kavmiyye, Arapça'da milliyetçilik kavramını karşılamak için modern dönemde ortaya çıkmış bir kelimedir. Ayrıca kavm karşılığı olarak ümmet kelimesi de kullanılır.
Map #417, Site 5MT10647, Nonstructure 117, Feature 1 (Pit), Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Nonstructure 117, Feature 1 (Pit), Stratigraphic Profile
CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males
Creators: name: Pennington, Kyla
name: Klaus, Kristel
name: Fachim, Helene A
name: Butler, Kevin
name: Trischel, Ksenia
name: Dalton, Caroline F
name: Heald, Adrian
name: Reynolds, Gavin P
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
CACNA1C
childhood trauma
cortisol
DNA methylation
rs1006737
stress

description: Aim: We investigated morning cortisol, stress, rs1006737 and childhood trauma relationship with CACNA1C methylation. Materials & methods: Morning cortisol release, childhood trauma and perceived stress were collected and genotyping for rs1006737 conducted in 103 adult males. Genomic DNA extracted from saliva was bisulphite converted and using pyrosequencing methylation determined at 11 CpG sites within intron 3 of CACNA1C. Results: A significant negative correlation between waking cortisol and overall mean methylation was found and a positive correlation between CpG5 methylation and perceived stress. Conclusion: CACNA1C methylation levels may be related to cortisol release and stress perception. Future work should evaluate the influence of altered CACNA1C methylation on stress reactivity to investigate this as a potential mechanism for mental health vulnerability.
title: Mineralogical and geochemical alterations in the Opalinus Clay and surrounding formations provide information about the long-term stability of this hydrogeochemical system
Creators: name: Bonitz, Marie
name: Hennig, Theresa
name: Schleicher, Anja M.
name: Jaeggi, David
name: Kühn, Michael
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The Opalinus Clay is the chosen host rock for the Swiss deep geological disposal of nuclear waste, and it is also investigated in Germany. For the long-term integrity of the disposal site, temporal and spatial stable geochemical conditions are essential. The identification of mineralogical and geochemical alterations in the Opalinus Clay and surrounding formations gives insights on their stability in the past, and thus enables an assessment for the future.

To detect the mobility of chemical elements and associated mineralogical changes, a 58 m long borehole was drilled at the Mont Terri Rock Laboratory (Switzerland). Drilling was conducted from the Opalinus Clay through the entire underlying Staffelegg Formation, which includes two water-bearing sections. The rock members and their transitions were characterised with a variety of analytical methods.

The results show that many trace elements are particularly enriched at the upper transitions of the water-bearing sections. At the top of the Rietheim Member (Posidonia Shale), this enrichment is accompanied by an increase in pyrite, which can be interpreted differently. On the one hand, the depositional conditions may have led to enhanced pyrite formation and the associated pyritization of trace metals. On the other hand, the overlying rock layers could have acted as cap rock for mobile elements in the pore water, leading to the observed accumulations. Consequently, to distinguish between depositional or diagenetic and alteration or mobilisation features is crucial for the interpretation of the analytical results in order to assess the long-term stability of Opalinus Clay and surrounding formations.
Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging: a systematic literature review
Creators: name: Evans, Jobie
name: Sapsford, Mark
name: McDonald, Scott
name: Poole, Kenneth
name: Raine, Tim
name: Jadon, Deepak R.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Systematic Review
ankylosing spondylitis
computed tomography
Crohn’s disease
enteropathic arthritis
inflammatory bowel disease
magnetic resonance imaging
spondyloarthritis
ulcerative colitis

description: Background:: Patients with inflammatory bowel disease (IBD) have an excess burden of axial spondyloarthritis (axSpA), which, if left untreated, may significantly impact on clinical outcomes. We aimed to estimate the prevalence of axSpA, including previously undiagnosed cases, in IBD patients from studies involving cross-sectional imaging and identify the IBD features potentially associated with axSpA. Methods:: PubMed, Embase and Cochrane databases were searched systematically between 1990 and 2018. Article reference lists and key conference abstract lists from 2012 to 2018 were also reviewed. All abstracts were reviewed by two authors to determine eligibility for inclusion. The study inclusion criteria were (a) adults aged 18 years or above, (b) a clinical diagnosis of IBD and (c) reporting identification of sacroiliitis using cross-sectional imaging. Results:: A total of 20 observational studies were identified: 12 used CT, 6 used MR and 2 utilised both computed tomography (CT) and magnetic resonance (MR) imaging. Sample sizes ranged from 25 to 1247 (a total of 4096 patients); 31 studies were considered to have low selection bias, 13 included two or more radiology readers, and 3 included rheumatological assessments. The prevalence of sacroiliitis, the most commonly reported axSpA feature, ranged from 2.2% to 68.0% with a pooled prevalence of 21.0% [95% confidence interval (CI) 17–26%]. Associated IBD features include increasing IBD duration, increasing age, male sex, IBD location, inflammatory back pain and peripheral arthritis. No significant difference in the prevalence of sacroiliitis between Crohn’s disease and ulcerative colitis was identified. Study limitations include variability in the individual study sample sizes and patient demographics. Conclusion:: This review highlights the need for larger, well-designed studies using more sensitive imaging modalities and multivariable modelling to better estimate the prevalence of axSpA in IBD. An improved knowledge of the IBD phenotype(s) associated with axSpA and use of cross-sectional imaging intended for IBD assessment to screen for axSpA may help clinicians identify those patients most at risk.
title: Milankovitch cycles in 2.5-Ga iron formations as archive of the early Earth and Earth-Moon system
Creators: name: Lantink, Margriet L.
name: Davies, Joshua H.F.L.
name: Hennekam, Rick
name: Lenstra, Wytze K.
name: Martin, David McB.
name: Mason, Paul R.D.
name: Ovtcharova, Maria
name: Reichart, Gert-Jan
name: Schaltegger, Urs
name: Slomp, Caroline P.
name: Hilgen, Frederik J.
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Regular stratigraphic alternations in lower Paleoproterozoic iron formations (IFs) from South-Africa and Western Australia were recently linked to Milankovitch forcing (1, 2). Hence, valuable information may potentially be obtained from these ancient marine deposits about early Solar System dynamics and astronomical-forced climate change when Earth System was operating in fundamentally different ways compared to present-day and the Phanerozoic. In particular, the dominant imprint of long-period eccentricity observed in the Kuruman IF from South-Africa (2) implied a primary influence of climatic precession, while clear precession-scale variations were unfortunately not encountered in this unit. A clear and consistent expression of precession and eccentricity, however, is essential to investigate the climatic-environmental response to the precessional forcing directly, and to determine the precession frequency as to potentially constrain past Earth-Moon dynamics. Here we report results of cyclostratigraphic analysis and high-precision U-Pb dating of the 2.46-Ga Joffre Member of the Brockman IF, Western Australia, revealing exceptionally regular precession- and eccentricity-scale alternations identified in both outcrop and core. Based on the thickness ratio between the precession- and short eccentricity-related alternations seen in outcrop, we estimate a significantly shorter precession period at the time of deposition of the Joffre Member, translating to a shorter Earth-Moon distance and length-of-day (3). In addition, based on detailed geochemical analysis and modelling of the precession-related cycles identified from core, we present a first-order climate interpretation with possible implications for the redox evolution of the ocean-atmosphere (4).

(1) de Oliveira Rodriguez et al. 2019; (2-4) Lantink et al. 2019; 2022; 2023.
Galaxy formation and evolution with Roman Space Telescope
Creators: name: Robertson, Brant
Publisher: name: Zenodo
Year: 2021
Subjects: Synergies with wavelengths and facilities

description: Roman Extragalactic Potential Observations (EXPO) Science Investigation Team. Roman will be transformative for studies of galaxy evolution and formation. Roman can teach us about the connection between galaxy evolution and cosmic environment. Roman will provide unprecedented spectroscopic samples during the peak of galaxy formation. Roman will provide the first statistical samples for studying early galaxy and quasar populations that cause cosmic reionization.
Beyond Uberization: The co-constitution of technology and organizing
Creators: name: Faraj, Samer
name: Pachidi, Stella
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Conversations and Controversies
contingency theory
information systems
innovation
organizational form
science and technology studies (STS)
technology

description: Uberization has emerged as a platform-based form of organizing that is reshaping work and labour markets and that is fundamentally challenging existing thinking on organizing. We suggest that organizational theorists have been reluctant to address the constitutive relation between technology and organizing. By emphasizing co-constitution, we argue against viewing technology as an entity that is separate, exogenous, or causal. Instead, we offer that technology can be fruitfully viewed as endogenous to and constitutively entwined with organizational actions and structures. To illustrate this co-constitution, we present a brief analysis of Uberization from a regime of organizing perspective that emphasizes how organizing practices, valuation schemes, authority arrangements and technological arrangements are entwined with each other. We conclude with an invitation to organizational theorists to more specifically engage with technology as they theorize new forms of organizing.
title: Lithium isotope compositions of various biogenic carbonates throughout the mid-Cretaceous – Challenges of reconstructing δ7LiSW in deep time
Creators: name: Schlidt, Vanessa
name: Huber, Sandra Janina
name: Hoffmann, René
name: Heimhofer, Ulrich
name: Erba, Elisabetta
name: Bottini, Cinzia
name: Huck, Stefan
name: Seitz, Hans-Michael
name: Voigt, Silke
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The evolution of the seawater Lithium isotope composition (δ7LiSW) depends on the prevalent weathering regime. To reconstruct δ7LiSW, and thus, weathering congruency, two main archives are widely used: calcareous fossils and bulk carbonate sediments. Either of these archives has its strong and weak points. While carbonate sediments are prone to diagenesis and clay contamination, biogenic skeletons may exhibit strong vital effects on δ7LiSW. Here, we present δ7LiSW data for the mid-Cretaceous derived from various biogenic carbonates such as bivalves (mainly rudists), cephalopods, and brachiopods from well-known sample sites across Europe.

Additionally, we assessed the extent of taxon-specific vital effects on δ7Li for well-preserved Albian molluscs from Madagascar (Mahajanga Basin, age 110.5 +/-0.5Ma) and compared them with data for modern taxonomic groups.

Our most complete data set derives from rudist shells (mainly requieniid rudists) from the mid-Barremian to early Aptian sample locations of Sausset (Urgonian Limestone Formation, France), Ericeira (Crismina Formation, Portugal), Kanfanar (Kanfanar unit, Croatia), and Miravete (Villarova de los Pinares Formation, Spain). We compare their δ7Li compositions and trends therein with that of cotemporaneous carbonate-rich sediments. We provide preliminary δ7LiSW for several time intervals which range between 22-25‰ on average with values exceeding 30‰ in the late Barremian.

Relative to published bulk carbonate data, we observe a systematic offset for rudist-shell δ7Li values of 3-8‰ towards heavier values. We assign this offset to vital effects similar to those known for modern calcitic molluscs.
title: Locomotion Transition Strategy of Hybrid Track-Legged Ground Robots
Creators: name: Johnson, Anastasia Rea Jean
Publisher: name: Graduate Studies
Year: 2025
Subjects: subject: Hybrid Robots
subject: Locomotion Transition
subject: Track-Legged
subject: Stability
subject: Engineering--Mechanical
subject: Robotics

description: Single locomotion mode robots have been used in urban search and rescue (USAR) operations, but their mobility and navigation capabilities are often inadequate for the complex and confined spaces encountered in such scenarios. To overcome these limitations, hybrid robots with advanced locomotion capabilities have been proposed. However, these hybrid robots face their own set of challenges, including mechanical design, control complexity, environmental adaptability, stability, and the need for smooth locomotion transitions. This thesis document aims to develop a locomotion transition algorithm that enhances the locomotion capabilities and maximizes stability of hybrid robots across heterogeneous complex terrains. Building on previous research, this thesis addresses the limitations of traditional static stability measures, such as Static Stability Margin (SSM) and the Normalized Energy Stability Margin (NESM), particularly in environments with variable slopes. The research introduces an enhanced version of NESM termed the Enhanced Normalized Energy Stability Margin (ENESM) which modifies existing equations to account for terrains observed as having both pitch and roll angles with respect to the robot's direction of motion. This thesis details the formulation of ENESM and the development of a locomotion transition algorithm which is then used for enabling hybrid robots to transition between quadrupedal (crawl) and bipedal gaits based on the perceived terrain. Simulations on various terrain conditions and robot locomotion modes are employed to validate the proposed formulations and algorithm. The results demonstrate improved stability and adaptability, enabling effective gait transitions across flat and complex sloped terrains. These findings advance the field of robotic mobility by providing a more robust solution for locomotion mode transitions in heterogeneous unstructured challenging environments, and maximizing robot movements. Proposed future work includes expanding the algorithm to incorporate additional locomotion characteristics (e.g. energy efficiency or speed) to enable additional locomotion modes (e.g. rolling).
Polyglycerol-based hydrogels and nanogels: from synthesis to applications
Creators: name: Kumari, Meena
name: Prasad, Suchita
name: Fruk, Ljiljana
name: Parshad, Badri
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Review
chemical cross-linking
hydrogel
nanogel
polyglycerol

description: Hydrogels and nanogels have emerged as promising materials for biomedical applications owing to their large surface area and tunable mechanical and chemical properties. Their large surface area is well suited for bioconjugation, whilst the interior porous network can be utilized for the transport of valuable biomolecules. The use of biocompatible hydrophilic building blocks/linkers for the preparation of hydrogels and nanogels not only avoids undesired side effects within the biological system, but also retains high water content, thereby creating an environment which is very similar to extracellular matrix. Their tunable multivalency and hydrophilicity and excellent biocompatibility, together with ease of functionalization, makes polyglycerol macromonomers well suited for synthesizing cross-linked networks that can be used as extracellular matrix mimics. Here we provide an overview of the synthesis of polyglycerol-based hydrogels and nanogels for various biomedical applications.
Metabolically healthy obesity in children attending pediatric weight-management programs in Canada
Creators: name: Bains, Amandeep
Publisher: name: University of British Columbia
Year: 2023

description: Background: Childhood obesity continues to be a global health concern.¹ Health risks associated with childhood obesity include hypertension and orthopedic disorders, among others.² However, not all children with obesity present with obesity-associated health risks.³,⁴ These health risks are thought to be part of one’s obesity phenotype.⁵ Distinguishing among them may lead to better treatment and management strategies.⁶⁻⁸ For this reason, obesity without metabolic syndrome health risk factors (i.e., lowered HDL, elevated triglycerides, blood pressure, fasting glucose) is known as metabolically healthy obesity (MHO), and those with abnormal metabolic markers are classified as metabolically unhealthy obesity (MUO).⁵,⁹ Objectives: Using data from the CANadian Pediatric Weight-Management Registry (CANPWR), this thesis aims to (i) establish the prevalence of MHO in participants 6-17 years old at baseline and one-year follow-up; and (ii) explore which health behaviour factors (diet, physical activity, sedentary, and sleep behaviours) are associated with MHO status. Methods: This secondary analysis included participants (n = 387, 52.7% female; mean age: 12.8 ± 2.9 years). Questionnaires were used to capture all non-metabolic variables. T-tests and chi-square tests were used to analyze continuous and categorical variables. Anthropometrics and biochemical assessments occurred at CANPWR sites at baseline and 1-year. Results: At baseline, n = 135 (34.9%) of participants were classified as MHO; n = 254 (65.1%) were identified as MUO. At follow-up, a similar percentage were classified as MHO (34.4%) and MUO (65.6%). However, n = 108 (27.9%) participants who were MHO at baseline presented as MUO at follow-up. Reported lifestyle behaviours that significantly differed for MHO/MUO were inconsistent at baseline and follow-up (baseline: fruit juice intake, weekly screen time hours, computer/video game hours; follow-up: fruit, ice cream/frozen yogurt intake). A lower BMI z-score was associated with MHO at both baseline and follow-up. Conclusion: The overall prevalence of MHO and MUO was similar at baseline and follow-up. Further analyses revealed variables that predicated this switching of status. This study highlights the need for more research in assessing metabolic health of children who are referred to weight-management programs, as children can present with worsening of metabolic health status at follow-up.
title: Optimizing large star-schema queries with snowflakes via heuristic-based query rewriting
Creators: name: Tao, Yingying
name: Zhu, Qiang
name: Zuzarte, Calisto
name: Lau, Wing
Publisher: name: University of Michigan
Year: 2024

description: User queries have been becoming increasingly complex (e.g., involving a large number of joins) as database technology is applied to some application domains such as data warehouses and life sciences. Query optimizers in existing database management systems often suffer from intolerably long optimization time and/or poor optimization results when optimizing large join queries. One possible solution to tackle these problems is to rewrite a user-specified complex query into another form that can better utilize the capability of the underlying query optimizer, based on some heuristic rules, before sending the query to the next query optimization stage. We focus on studying a special type of complex query possessing a star-schema structure with snowflakes, simply called the snow-schema query. The key idea is to split a given snow-schema query into several levels of small query blocks at the query rewriting stage. The query optimizer then optimizes the query blocks and integrates their results into the final query result. A set of heuristic rules on how to divide the query is introduced. A query rewriting framework adopting these heuristics is presented. Experimental results demonstrate that this heuristic-based query rewriting technique is quite promising in optimizing large snow-schema queries.
Nonlinear conductance and noise in boundary sine-Gordon and related models
Creators: name: Honer, J.
name: Weiss, U.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study a conjecture by Fendley, Ludwig and Saleur for the nonlinear conductance in the boundary sine-Gordon model. They have calculated the perturbative series of twisted partition functions, which require particular (unphysical) imaginary values of the bias, by applying the tools of Jack symmetric functions to the "log-sine" Coulomb gas on a circle. We have analyzed the conjectured relation between the analytically continued free energy and the nonlinear conductance in various limits. We confirm the conjecture for weak and strong tunneling, in the classical regime, and in the zero temperature limit. We also shed light on this special variant of the ${\rm Im} F$-method and compare it with the real-time Keldysh approach. In addition, we address the issue of quantum statistical fluctuations.
description: 27 pages, 2 figures
Map #431, Site 5MT10647, Midden 213 and Arbitrary Units 209 and 222, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2017
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Midden 213 and Arbitrary Units 209 and 222, Stratigraphic Profile