cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The influence of excipients on physical and pharmaceutical properties of oral lyophilisates containing a pregabalin-acetaminophen combination
Creators: name: Chiriac, Aurica P.
name: Diaconu, Alina
name: Nita, Loredana E.
name: Tudorachi, Nita
name: Mititelu-Tartau, Liliana
name: Creteanu, Andreea
name: Dragostin, Oana
name: Rusu, Daniela
name: Gratiela Popa
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Objectives: The purpose of the study was to investigate and characterize the oral lyophilisates containing the pregabalin-acetaminophen drug combination and as xcipients mannitol with microcrystalline cellulose or hydroxypropyl methylcellulose, in order to conclude upon drug-excipient interactions and their stability implications, impact of excipients on drug release and on the physicochemical and mechanical properties of the pharmaceutical formulations. Methods: The oral tablets were made by using a Christ freeze-dryer alpha 2–4-LSC lyophilizer, and evaluated for stability, drug-excipient compatibility and homogeneity of the prepared pharmaceutical formulations. The formulations were evaluated for in vivo absorption in rabbits by histopathological exams. Results: FTIR and thermogravimetric analyses, DLS technique, SEM and NIR-CI studies confirmed the compatibility between compounds. From the determined physical and biochemical parameters of the formulations it was established that they are stable, homogeneous, and meet the conditions for orally disintegrating tablets. Conclusion: In the case of the investigated pharmaceutical formulations the study evidenced the assembling through physical bonds between the excipients and the ‘codrug’ complex, which do not affect the release of the bioactive compounds.
Electron paramagnetic resonance and transmission electron microscopy study of the interactions between asbestiform zeolite fibers and model membranes
Creators: name: Cangiotti, Michela
name: Battistelli, Michela
name: Salucci, Sara
name: Falcieri, Elisabetta
name: Mattioli, Michele
name: Giordani, Matteo
name: Ottaviani, Maria Francesca
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Different asbestiform zeolite fibers of the erionite (termed GF1 and MD8, demonstrated carcinogenic) and offretite (termed BV12, suspected carcinogenic) families were investigated by analyzing the electron paramagnetic resonance (EPR) spectra of selected surfactant spin probes and transmission electron microscopy (TEM) images in the presence of model membranes—cetyltrimethylammonium (CTAB) micelles, egg-lecithin liposomes, and dimyristoylphosphatidylcholine (DMPC) liposomes. This was undertaken to obtain information on interactions occurring at a molecular level between fibers and membranes which correlate with entrance of fibers into the membrane model or location of the fibers at the external or internal membrane interfaces. For CTAB micelles, all fibers were able to enter the micelles, but the hair-like structure and chemical surface characteristics of GF1 modified the micelle structure toward a bilayer-like organization, while MD8 and BV12, being shorter fibers and with a high density of surface interacting groups, partially destroyed the micelles. For liposomes, GF1 fibers partially penetrated the core solution, but DMPC liposomes showed increasing rigidity and organization of the bilayer. Conversely, for MD8 and BV12, the fibers did not cross the membrane demonstrating a smaller membrane structure perturbation. Scolecite fibers (termed SC1), used for comparison, presented poor interactions with the model membranes. The carcinogenicity of the zeolites, as postulated in the series SC1
Dietary sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyle (MEAL) study cohort
Creators: name: Godos, Justyna
name: Marventano, Stefano
name: Mistretta, Antonio
name: Galvano, Fabio
name: Grosso, Giuseppe
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The aim of this study was to estimate the dietary intake and major food sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyles (MEAL) study cohort. A total of 1937 individuals (18 + y) of urban population of Catania, Italy, completed a validated 110-item food frequency questionnaire; Phenol-Explorer database was used to estimate polyphenol intake. Mean intake of polyphenols was 663.7 mg/d; the most abundant classes were phenolic acids (362.7 mg/d) and flavonoids (258.7 mg/d). The main dietary sources of total polyphenols were nuts, followed by tea and coffee as source of flavanols and hydroxycinnamic acids, respectively, fruits (i.e. cherries were sources of anthocyanins and citrus fruits of flavanones) and vegetables (i.e. artichokes and olives were sources of flavones and spinach and beans of flavonols); chocolate, red wine and pasta contributed to flavanols and tyrosols, respectively. These findings will be useful to assess the potential benefits of foods with high polyphenol content.
title: OFROM: interview avec unifr18a05d
Creators: name: Delafontaine, François
name: Patenaude, Allyssia
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.6bdbop4c.v2#cbe6153c2b61109b6a2b27686ebb38742042e821
An improved two-stage procedure to compare hazard curves
Creators: name: Zhongxue Chen
name: Hanwen Huang
name: Peihua Qiu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Qiu and Sheng has proposed a powerful and robust two-stage procedure to compare two hazard rate functions. In this paper we improve their method by using the Fisher test to combine the asymptotically independent p-values obtained from the two stages of their procedure. In addition, we extend the procedure to situations with multiple hazard rate functions. Our comprehensive simulation study shows that the proposed method has a good performance in terms of controlling the type I error rate and of detecting power. Three real data applications are considered for illustrating the use of the new method.
Additional file 10: Table S6. of Identification of regulatory modules in genome scale transcription regulatory networks
Creators: name: Song, Qi
name: Grene, Ruth
name: Heath, Lenwood
name: Li, Song
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Algorithm: Generate simulated network (PDF 355 kb)
Additional file 11: Figure S5. of Identification of regulatory modules in genome scale transcription regulatory networks
Creators: name: Song, Qi
name: Grene, Ruth
name: Heath, Lenwood
name: Li, Song
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: FOS: Biological sciences

description: Network duplication and rewiring. We randomly selected a subset of nodes from the whole network then duplicated them. New nodes that were duplicated from the original nodes are referred as ‘pseudo node’. In the figure, A′ and E′ are the pseudo nodes of A and E, respectively. This means before rewiring occurs, A′ and E′ duplicated all the edges from A and E (These duplicated edges are the dashed edges in the figure). For rewiring, CoReg first goes through every edge connecting to A′ and attempts to rewire the edge with given probability. Once CoReg decides to rewire that edge, another edge in the network will be randomly selected. Then the target nodes for these two edges will be exchanged. In the case shown above, the two edges marked by red box have their target nodes swapped. Therefore, rewiring only applies on pseudo nodes and the original graph remains unchanged during the process (PDF 27 kb)
Species limits and morphometric and environmental variation within the South Andean and Patagonian Mulinum spinosum species-group (Apiaceae-Azorelloideae)
Creators: name: Fernández, Martina
name: Ezcurra, Cecilia
name: Calviño, Carolina I.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Delimiting species is an important, but frequently difficult aspect of systematics that should be addressed using data from multiple sources. Here we combine morphometric analyses and environmental characteristics to delimit species in the South Andean and Patagonian taxonomically difficult species-group composed by Mulinum spinosum, M. echinus and M. leptacanthum (Apiaceae-Azorelloideae). Molecular phylogenies have shown that these three species form part of a polytomy together with other Mulinum species, and therefore these data are not useful for their delimitation. We include measurements of 25 morphometric variables from 163 herbarium specimens and perform univariate and multivariate principal component analysis (PCA) and discriminant analysis (DA) to establish the limits amongst the three mostly sympatric, morphologically similar, and phylogenetically unresolved species. We also use 19 bioclimatic and three geographic variables from localities of the specimens to infer environmental characteristics of the taxa and test their relation with morphological variation. Morphological evidence supports the inclusion of M. echinus within the morphologically and climatically variable M. spinosum, and rejects its recognition as a distinct taxon at any rank. On the contrary, M. leptacanthum is considered a morphologically distinct species, generally restricted to high altitude areas of the southern Andes with a cooler and wetter climate. Within the widespread M. spinosum, environmental gradients of precipitation and temperature relate to morphological gradients (e.g., in leaf and inflorescence sizes, in leaf acicularity, and in fruit-wing width). These last results showed that the large morphological variation in vegetative and reproductive characteristics of this species that grows in arid and semiarid habitats are related to regional climatic gradients that have probably been important in the evolution of this species' plasticity, diversification, and differentiation.
A reappraisal of the genus Megacaryon (Boraginaceae, Lithospermeae) based on molecular, morphological, and karyological evidence
Creators: name: Selvi, Federico
name: Cecchi, Lorenzo
name: Hilger, Hartmut H.
name: Coppi, Andrea
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The systematic position and phylogenetic relationships of Echium orientale, a rare endemic of the mountains of northern Turkey, were elucidated based on morphological, molecular, and karyological evidence. Using nuclear and plastid DNA sequences, we found that this species is not included in Echium, but is rather at least as divergent from it as other related lineages, namely the South African Lobostemon and Echiostachys. Pollen characters revealed a strong affinity with Onosma, especially in the non-reticulate ornamentation of the tectum. Fruit morphology is unique in the genera of the Echium ‘alliance' (e.g. Echium, Pontechium, Lobostemon, and Echiostachys), because of the large size and the smooth, glossy nutlet surface as in most species of Onosma. Karyological observations show that this species is diploid with 2n = 12, and differing from both Lobostemon or Echium, where nearly all species have higher numbers (usually 2n = 14 and 2n = 16, respectively). Combined with a ‘megaherb' habit, the weak zygomorphism of the large flowers and a restricted range in the humid mountain forests of the Black Sea region, fruit, pollen and chromosome characters suggest an isolated position for E. orientale in the Echium alliance. We therefore propose its placement in the monotypic Megacaryon, a genus originally described by Boissier, but largely disregarded by later botanists. An original specimen is designated as generic lectotype.
Additional file 1: Figure S1. of Identification of regulatory modules in genome scale transcription regulatory networks
Creators: name: Song, Qi
name: Grene, Ruth
name: Heath, Lenwood
name: Li, Song
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Co-regulation pattern in networks with different co-regulation probability (specified by the parameter prob). Network with higher prob is expected to have stronger co-regulation pattern. We generated two modules ‘a’ and ‘b’ in this example network. Modules are marked by different color. Zero-degree auxiliary nodes were not shown in the Fig. A) network generated with prob = 0.1 B) network generated with prob = 0.9 (PDF 38 kb)
title: 02_0792
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: OFROM: interview avec unifr19a11m
Creators: name: Delafontaine, François
name: Risse, Lisiane
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.dd3azwt8.v2#fb1ec1446a3590c2f7349da0477a5c4cce897250
Additional file 2: Figure S2. of Identification of regulatory modules in genome scale transcription regulatory networks
Creators: name: Song, Qi
name: Grene, Ruth
name: Heath, Lenwood
name: Li, Song
Publisher: name: figshare
Year: 2017
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Evaluation of different module-finding methods using simulated networks with different parameters. From top row to bottom row: mSize = 5, mSize = 15, mSize = 20. From left most column to right most column: targetNumÂ = 5, targetNum = 15, targetNum = 20. (PDF 73 kb)
Sensitivity of western Canadian Pyrenophora teres f. teres and P. teres f. maculata isolates to propiconazole and pyraclostrobin
Creators: name: Alireza Akhavan
name: Strelkov, Stephen E.
name: Askarian, Homa
name: Kher, Swaroop V.
name: Fraser, Michelle
name: H. Randy Kutcher
name: T. Kelly Turkington
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Pyrenophora teres f. teres (Ptt) and Pyrenophora teres f. maculata (Ptm), the causal agents of the net and spot forms of net blotch of barley, respectively, can be managed in western Canada with fungicides containing propiconazole and pyraclostrobin. Given the potential for development of fungicide resistance, the sensitivity of a collection of Ptt and Ptm isolates to propiconazole and pyraclostrobin was evaluated using microtitre plate bioassays. The concentration of propiconazole needed to inhibit fungal growth by 50% (EC50) was 1.5 mg L−1 for Ptt and 2.3 mg L−1 for Ptm, while the EC50 of pyraclostrobin was 0.015 mg L−1 for Ptt and 0.024 mg L−1 for Ptm. Subsequently, 39 Ptt and 27 Ptm isolates were screened with discriminatory doses of 5 mg propiconazole L−1 and 0.15 mg pyraclostrobin L−1. Inhibition of growth as a result of propiconazole was 12–95% for Ptt and 48–92% for Ptm; growth inhibition as a result of pyraclostrobin was 40–100% and 24–100%, respectively. Two Ptt isolates were insensitive to propiconazole, while one Ptm isolate was insensitive to pyraclostrobin. The latter also showed decreased sensitivity to propiconazole. The identification of net blotch isolates insensitive to these fungicides emphasizes the need for farmers to employ integrated crop management strategies to avoid fungicide resistance build-up.
Additional file 1 of Identification of a robust functional subpathway signature for pancreatic ductal adenocarcinoma by comprehensive and integrated analyses
Creators: name: Wang, Ping
name: Chunlong Zhang
name: Weidong Li
name: Zhai, Bo
name: Jiang, Xian
name: Reddy, Shiva
name: Hongchi Jiang
name: Xueying Sun
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Descriptive summary of datasets used in the study. Table S2. Genes of the 00982_1 subpathway. Table S3. Predictive power of published gene signatures. Figure S1. Dataset Search strategy in GEO database. Figure S2. Flow diagram of dataset selection strategies. Figure S3. Accumulative predictive abilities of signatures. Figure S4. Genes in the path:00982_1 subpathway. Figure S5. Collision classification for GSE57495 and GSE79668 datasets. Figure S6. Prognostic capacity of path:00982_1 signature for classical subtype. by Moffitt classification. Figure S7. Association of path:00982_1 subpathway with other pathways.
title: "La lettre d'ICCARRE : état des lieux et projections"
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 fichier (3 pages).
Early Jurassic metamorphism of the eastern segment of the Lhasa terrane in South Tibet and its tectonic significance
Creators: name: Chen, Zhi-Jia
name: Tian, Zuo-Lin
name: Zhang, Ze-Ming
name: Dong, Xin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The metamorphic belt in the Dongjiu area is located in the eastern segment of the Lhasa terrane in South Tibet. The Dongjiu metamorphic rocks are primarily composed of schist and gneiss, with minor amounts of marble, and the protoliths are sedimentary rocks with Precambrian and early Palaeozoic zircons probably deposited during the Palaeozoic or late Neoproterozoic. On the basis of petrology and phase equilibria modelling, this study shows that the Dongjiu metamorphic belt has experienced a kyanite-grade metamorphism, which is characterized by a decompressional vector with slight cooling from a peak of 9.6 kbar and 745°C to medium-pressure amphibolite-facies metamorphic overprinting at 5–6 kbar and 600–630°C. This P–T path was well recorded and recovered by garnet zoning profiles. Laser ablation inductively coupled plasma mass spectrometry in situ U–Pb analyses on metamorphic zircons and zircon rims yielded concordant 206Pb/238U ages of c. 194–192 Ma, suggesting that the Dongjiu metamorphic rocks were formed during the Early Jurassic. Therefore, the Dongjiu metamorphic belt, together with the western Nyainqentanglha, Basongco, and Zhala metamorphic belts, constitutes a nearly continuous tectonic unit with an E–W extension of at least 500 km between the northern and southern Lhasa terranes. The metamorphic ages of these belts, ranging from 230 to 192 Ma, show a younger trend from west to east, indicating that the central segment of the Lhasa terrane experienced an eastward asynchronous collisional orogeny during the Late Triassic to Early Jurassic.
Additional file 1: Figure S1. of Inhibition of EGR1 inhibits glioma proliferation by targeting CCND1 promoter
Creators: name: Chen, Dian-gang
name: Zhu, Bo
name: Lv, Sheng-qing
name: Zhu, Hongfan
name: Tang, Jinliang
name: Huang, Changlin
name: Li, Qingrui
name: Zhou, Pu
name: Wang, Dong-lin
name: Li, Guang-hui
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Identification and characterization of U251 stem-like cells(USLC). Figure S2. Schematic diagram of the EGR1 binding site in CCND1 promotor. Figure S3. The mRNA expression of EGR1 and CCND1 at different points in time after adding EGF in U251 cells. Figure S4. The another two databases apart from JASPAR to corroborate the EGR1 binding site. Figure S5. Negative controls for the immunohistochemistry. Figure S6 GAPDH promoter is regulated by EGR1. Figure S7. The positive expression control for EGR1, to validate the antibody. (DOC 2277Â kb)
title: OFROM: interview avec unifr19a10d
Creators: name: Delafontaine, François
name: Niederer, Claire
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.1b1bq90q.v2#4116d7f50d24cea8dd2608e1bf4732e4f03fc565
Novel thermoresponsive water-soluble oligomers based on amphiphilic calixresorcinarenes
Creators: name: Ya. V. Shalaeva
name: Ju. E. Morozova
name: V. V. Syakaev
name: E. Kh. Kazakova
name: A. M. Ermakova
name: I. R. Nizameev
name: M. K. Kadirov
name: A. I. Konovalov
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Novel water-soluble thermoresponsive oligomers TO1 and TO2 were obtained by reaction of amidoamine tetramethylcalixresorcinarenes (C1) and tetrapentylcalixresorcinarenes (C5) with ethylene glycol diglycidyl ether. The compounds were characterised by 1H and FT-PGSE NMR, FTIR, static light scattering and elemental analysis. The thermoresponsive properties of oligomers were investigated by spectrophotometry, DLS, FT-PGSE NMR and TEM. The cloud points of oligomers (43 °C for TO1 (5 mg/ml) and 41 °C for TO2 (1.2 mg/ml), respectively) were determined. The influence of salts effect on TO2 cloud points was investigated. The binding of anti-inflammatory drug naproxen (Nap) at 20 °C by TO1 and TO2 and its partial release at cloud points of oligomers in aqueous solution are observed using fluorescence and FT-PGSE NMR methods. New example of creating of thermoresponsive macrocyclic systems on the basis of amidoamine calixresorcinarenes with possibility of substrate binding and release under the influence of termo-stimuli in an aqueous solution was shown.
title: The Effects of Ovarian Hormone Fluctuations and Hormonal Contraceptives on the Psychophysiological Responses Underpinning Endurance Performance
Creators: name: Wiggins, Brooklyn Marie
Publisher: name: Kinesiology
Year: 2025
Subjects: subject: Exercise
subject: Menstrual cycle
subject: Eumenorrheic
subject: Oral contraceptive
subject: Intrauterine device
subject: Neuromuscular fatigue
subject: Health
subject: Physiology
subject: FOS: Biological sciences

description: The extent and severity to which the menstrual cycle (MC) impacts exercise performance have shown divergent results in the literature. Accordingly, more research is needed to investigate exercise performance and associated psychophysiological responses in eumenorrheic (EUM) women and hormonal contraceptive users. Currently, the lack of consistent findings has prompted concern about including women in exercise science research, which has led to a disparity in female participant representation. This study investigated the effects of ovarian hormone fluctuations and hormonal contraceptives on endurance exercise performance and associated neurophysiological, cardiorespiratory, metabolic, and perceptual responses. After a ramp-incremental test, EUM women, combined monophasic oral contraceptive pill (OCP) users, and hormonal intrauterine device (hIUD) users (n=17 in each group) completed two experimental sessions consisting of cycling at 5% below the respiratory compensation point until task failure. In the OCP and EUM groups, sessions were performed in the active and inactive pill phases, and early follicular (EFP) and mid-luteal phases (MLP), respectively. In the hIUD group, sessions were separated by ~14 days. MC phases were determined using calendar-based counting, ovulation tests, and serum hormone analysis. Neurophysiological responses were measured by neuromuscular assessments, which included isometric knee extension maximum voluntary contractions superimposed with electrical stimulation of the femoral nerve and transcranial magnetic stimulation of the motor cortex, and electromyography recordings for evaluation of corticospinal excitability and inhibition. These assessments were performed at baseline, every 5 min during cycling, and at task failure. Effort, leg pain, fatigue, dyspnea, metabolic factors, and cardiorespiratory responses were recorded during cycling. Endurance performance was greater in the EFP compared to the MLP in EUM women (62.23±16.34 min vs. 53.63±14.80 min; P=0.003) and was similar between phases for OCP users (46.71±16.96 min vs. 48.46±13.94 min; P=0.537) and sessions for hIUD users (51.06±16.49 min vs. 49.71±16.25 min; P=0.613). Neurophysiological, cardiorespiratory, metabolic, and perceptual responses were similar between groups and phases (P>0.069); however, leg pain was affected by MC phases (P<0.028). These findings demonstrate that endurance exercise performance in OCP and hIUD users was consistent across phases and sessions, respectively, while a MC phase-mediated difference was observed in EUM women.
CRITICAL ORGANIZATIONAL LEARNING FOR COST LEADERSHIP STRATEGY AND PERFORMANCE: STUDY OF TELECOM SECTOR IN PAKISTAN
Creators: name: Adil T. Paracha, Wajid Shakeel
Publisher: name: TuEngr Group
Year: 2020
Subjects: Knowledge dimensions
Knowledge distribution
Organization learning dimensions
Organization performance
External Knowledge Acquisition
Internal Knowledge Acquisition.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 2, 11A02C: 1-16
Additional file 3: Figure S3. of Identification of regulatory modules in genome scale transcription regulatory networks
Creators: name: Song, Qi
name: Grene, Ruth
name: Heath, Lenwood
name: Li, Song
Publisher: name: figshare
Year: 2017
Subjects: Biochemistry
Physical Sciences not elsewhere classified
Molecular Biology
Biological Sciences not elsewhere classified
Developmental Biology
Marine Biology

description: Rewiring recall score for LP, WT and EB in real networks. We rescaled the y-axis to highlight the differences in the curves for LP, WT and EB (PDF 29 kb)
IMPACT OF OWNERSHIP STRUCTURE AND BOARD COMPOSITION ON FINANCIAL DISTRESS OF PAKISTAN STOCK EXCHANGE LISTED MANUFACTURING FIRMS
Creators: name: Muhammad Kashif Khurshid, Hazoor Muhammad Sabir
Publisher: name: TuEngr Group
Year: 2020
Subjects: Emerging Markets Score
Ownership Structure
Board Composition
Managerial Ownership
Individual Ownership
Institutional Ownership
Z Score
Board Size
CEO Duality
Ownership Concentration.

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 2, 11A02F: 1-14
title: OFROM: interview avec unifr19a08d
Creators: name: Delafontaine, François
name: Kamber, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.e7bc7i7k.v2#8d17cec686bda1716d7470fbd906fcd72e4a7f35
Ratiometric electrochemical detection of Pd•••π interactions: application towards electrochemical molecular logic gates
Creators: name: Goggins, Sean
name: Stark, Oliver P.
name: Naz, Christophe
name: Marsh, Barrie J.
name: Frost, Christopher G.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: The widespread and large scale use of platinum group metals, especially palladium, in a wide variety of industrial applications has seen their levels in wastewater streams, roadside dust and even pharmaceuticals significantly rise over recent years. Due to the possible environmental damage and potential health risk this may cause, there is now substantial demand for inexpensive, efficient and robust methods for the detection of palladium. Based upon self-immolative linker technologies, we have designed and synthesised a number of allyl ether-functionalised electrochemical probes to determine the optimum probe structure required to deliver a ratiometric electrochemical detection method capable of achieving a limit of detection of <1 mg/mL within 20 min through the use of disposable screen-printed carbon electrodes. Combined with an enzymatic assay, this method was then used to achieve a proof-of-principle ratiometric electrochemical molecular logic gate.
Additional file 1: Figure S1. of The influence of HK2 blood group antigen on human B cell activation for ABOi-KT conditions
Creators: name: Cao, Jingsong
name: Liu, Luogen
name: Zhang, Yunsheng
name: Xiao, Jianhua
name: Wang, Yi
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: the establishment of protein-gray value curve of BSA. (A) PAGE assay for different concentration of BSA, lane 1. 0.5 μg BSA, lane 2. 1 μg BSA, lane 3. 2 μg BSA, lane 4. 4 μg BSA, lane 5. 8 μg BSA; (B) the relationship analysis of BSA gray value and protein. Bars represent mean ± standard deviation (n = 3). (PDF 611 kb)
INFLUENTIAL FACTORS OF WATER BODY TO ENHANCE THE URBAN COOLING ISLANDS (UCIs): A REVIEW
Creators: name: Tasneem Mostofa, Golnoosh Manteghi
Publisher: name: TuEngr Group
Year: 2020
Subjects: Urban Heat Island (UHI)
Urban Microclimate
Urban Cooling Islands (UCI)
Water Bodies
Water Cooling Island (WCI).

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 2, 11A02G: 1-12
title: OFROM: interview avec unifr19a07d
Creators: name: Delafontaine, François
name: Imhof, Fabrice
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.de5b23j1.v2#f2f10ee6194a28885a43d60d749d4fec45f37ee3
Naphthalene and pyrrole substituted guanidine in selective sensing of Cu2+, Hg2+, Pb2+ and CN− ions under different conditions
Creators: name: Santanu Panja
name: Asoke P. Chattopadhyay
name: Kumaresh Ghosh
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Naphthalene and pyrrole substituted guanidine 1 has been designed and synthesised. Compound 1 efficiently distinguishes Cu2+, Hg2+ and Pb2+ ions by exhibiting different responses in fluorescence. While compound 1 exhibited turn-on emission selectively in the presence of Hg2+ and Pb2+ ions in CH3CN and CH3CN–H2O (1:1, v/v), respectively, it showed decrease in emission upon interaction with Cu2+ ion in CH3CN. Furthermore, the Cu-1 ensemble has been established as a potential probe for selective detection of CN− ion over a series of other anions involving colour change (in ordinary light: colourless to light yellow and under UV light: colourless to sky blue). Theoretical insight has been invoked to understand the mode of metal–ligand interaction. Naphthalene and pyrrole substituted guanidine 1 has been designed and synthesised. It efficiently distinguishes Cu2+, Hg2+ and Pb2+ ions by exhibiting different responses in fluorescence. The Cu-1 ensemble has been established as a potential probe for selective detection of CN- ion over a series of other anions involving colour change.
title: OFROM: interview avec unifr19a06a
Creators: name: Delafontaine, François
name: Henzelin, Sophie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.9c200w70.v2#579a596c518ab9b9e04c872b91335631908262c4
Additional file 9: Figure S4. of Identification of regulatory modules in genome scale transcription regulatory networks
Creators: name: Song, Qi
name: Grene, Ruth
name: Heath, Lenwood
name: Li, Song
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The example of bipartite transformation. Network on the left is a directed network, which could be transformed into a bipartite network on the right. The suffix ‘_h’ represents the head node and ‘_t’ means the tail node (PDF 11 kb)
title: Individual Medley: A Novel and “A victory makes it alright”: Fictionally Examining the Impact of Sport-Hero Culture on Developmental Athletes in Canada
Creators: name: Anderson, Hannah
Publisher: name: Arts
Year: 2025
Subjects: subject: Fiction
subject: Literature
subject: Creative Writing
subject: Athletics
subject: Canadian Sport
subject: Métis Identity
subject: Team Culture
subject: Physiology
subject: FOS: Biological sciences
subject: Literature--English
subject: Literature--Canadian (English)

description: Within the field of literatures in Canada, the majority of sports novels “are exceptional in their attempts to foster a monolithic national identity and safeguard traditional masculinity,” transforming male athletes into figures of legend that all athletes must measure up to (Buma 20). Existing literature “[celebrates] the traditional connection between masculinity and toughness” in male dominated sports at elite Olympic and World championship levels. Yet, female-identified athletes lack their own representation and role models. When women appear in sports stories, authors frequently limit their participation to “playing the male star’s girlfriend, mother, or temptress” (Vincentelli). Writing back to these representations and erasures, my creative writing dissertation – a novel entitled Individual Medley – opposes the domination of men in sports literature by tracking protagonist Camille Richard’s final meet in her competitive swimming career. Examining the systemic and cultural issues hindering young female athletes from long-term pursuit of competitive sport, this project highlights the implementation of high performance sport and “sacrifice mentality” in teenage athletes. Centering the female-identified body in athletics, Individual Medley examines athletes’ attitudes toward provincial, national, and international performance standards, the systems of coaching experienced by developing athletes, and the consequences of institutional regulation and bias – including chronic injury, athlete burnout, and rejection of sport. Incorporating the research collected in my SSHRC CGS-M creative writing thesis Spatial and my experiences as a former provincial swimmer and varsity rower, and current provincial rower, Individual Medley examines Canadian sports systems by frankly representing Canadian age group swimming as a specialization, and immerses readers in training and competition alongside female-identified athletes. As a high performance athlete and an experienced literary scholar, I use sensory imagery and an in-depth knowledge of team cultures – in multiple sports – and the athletic body to centre the narrative in sports themselves, rather than limiting athletics to a mere backdrop. This project consists of two components: Individual Medley as a novel, and an exegesis that critically examines both Individual Medley and its place in and kinship with the wider sports literature canon.
title: Revitalization of Brownfields in Russian and Baltic Cities: Comparing Interaction Models between Stakeholders  in Development Projects
Creators: name: Nekrasova, Ekaterina
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: Revitalization, Brownfields, Post-industrial territories, Redevelopment projects, Stakeholder interaction.

description: The post-socialist countries since the 1990s had to face both the transformational crisis towards free-market economy and the deindustrialization. It was accompanied by a large-scale closure of inefficient industries and resulted in a significant number of brownfields. Planning redevelopment projects of such post-industrial areas can be manifested in various forms of interaction between stakeholders. However, there has not been sufficient research that would attempt to identify models of stakeholder interaction in the planning stage of brownfield redevelopment projects. This paper is aimed at identifying and comparing stakeholder interaction models at the planning stage of redevelopment projects of former urban industrial areas in post-socialist countries, namely in Latvian, Lithuanian, Estonian and Russian cities. It is accomplished by comparing redevelopment contexts in these countries, and then exploring redevelopment cases of industrial territories in Baltic and Russian cities. Qualitative comparative analysis is based on case comparison by the ownership structure, redevelopment initiators, number of participating stakeholders, their type based on their involvement in the project, and funding model. Based on that, general approaches to the redevelopment of post-industrial areas and specific models of stakeholder interaction in the Baltic and Russian cities are identified and compared.
4C'S OF WORK ENVIRONMENT AND ORGANIZATIONAL PERFORMANCE: MEDIATING ROLE OF INDIVIDUAL PERFORMANCE
Creators: name: Saima Aftab, Komal Khalid
Publisher: name: TuEngr Group
Year: 2020
Subjects: Work environment
Performance-oriented Culture
Consultative Management
Career Planning
Communication
Individual and Organizational Performance

description: International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies, 11, 2, 11A02D: 1-16
Binding of malachite green promotes stability and shows preference for a human telomere DNA G-quadruplex
Creators: name: Uda, Ryoko M.
name: Matsui, Takashi
name: Takei, Michiko
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: A single-stranded human telomere DNA sequence can fold into an intramolecular G-quadruplex structure, which has been shown to inhibit telomerase activity. Small molecules that selectively target and stabilise the G-quadruplex structure have been proposed as potential anticancer drugs. In this study, we analysed the properties of binding of malachite green, a cationic triphenylmethane dye, to the G-quadruplex of d[(T2AG3)4] by UV spectroscopy of thermal melting analysis, a competitive equilibrium dialysis assay, and absorption and circular dichroism spectroscopies. When binding to malachite green, the quadruplex structure that formed in the presence of K+ ions was stabilised with an increase in melting temperatures by 6 °C. Malachite green showed selective binding to the G-quadruplex in the presence of duplex and single-stranded DNAs, owing to which it presents higher potential for anticancer therapy, compared to other triphenylmethane dyes. The induced signals of circular dichroism indicate that the binding mode of malachite green involves intercalation between adjacent guanine tetrads of the G-quadruplex.