cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Isonychus minutus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Melolonthidae
Isonychus
Isonychus minutus

description: Isonychus minutus (Fabricius, 1801)
Trichius minutus Fabricius 1801b: 134 (South America)
Distribution. French Guiana: Dalla Torre 1913: 326; Blackwelder 1944: 230; Evans and Smith 2009: 242. Brazil: Dalla Torre 1913: 326; Blackwelder 1944: 230; Frey 1970: 134; Evans and Smith 2009: 242. Other: Fabricius 1801b: 134 (South America - as Trichius minutus).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 112, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.03.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Predictive modeling to identify potential participants of a disease management program hypertension
Creators: name: Lenti, Pamela
name: Kottmair, Stefan
name: Stock, Stephanie
name: Shukri, Arim
name: Müller, Dirk
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Based on the premise of limited health-care resources, decision-makers pursue to allocate disease management programs (DMP) more targeted. Based on routine data from a private health insurance company, a prediction model was developed to estimate the individual risk for future in-patient stays of patients eligible for a DMP Hypertension. The database included anonymous claims data of 38,284 policyholders with a diagnosis in the year 2013. A cutoff point of ≥70% was used for selecting candidates with a risk for future hospitalization. Using a logistic regression model, we estimated the model’s prognostic power, the occurrence of clinical events, and the resource use. Overall, the final model shows acceptable prognostic power (detection rate = 64.3%; sensitivity = 68.7%; positive predictive value (PPV) = 64.1%, area under the curve (AUC) = 0.72). The comparison between the selected hypothetical DMP-group with a predicted (LOH) ≥70% showed additional costs of about 69% for the DMP-group compared to insure with a LOH <70%. The predictive analytical approach may identify potential DMP participants with a high risk of increased health services utilization and in-patient stays.
Sonnenfleckenzeichnung Nr. 22858.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 30.07.1968, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Competing fatigue mechanisms in Ni-Base superalloy Rene 88DT
Creators: name: Chang, Paul N.
Publisher: name: University of Utah
Year: 2012
Subjects: Competing
Fatigue
Rene? 88DT
S-N curve
Superalloys

description: Nickel base superalloys exhibit superior high temperature mechanical properties required for aircraft engine components. It has been known that the processing of these alloys by the powder metallurgy route introduces inclusions inside the material. The  presence of such inclusions often leads to competing failure modes in fatigue that is described by a step-wise or two distinct S-N curves involving both the surface and  internally-initiated cracks, resulting in large uncertainties of fatigue life. A clear understanding of such behavior is yet to be established.  The principal objective of this research is to examine the effect of inclusions on the extent of fatigue failure competition from surface and internal initiators at two  different specimen test volumes. Experimental fatigue testing has been performed to explore how the presence of inclusions affects the competing fatigue failure modes. In addition, how the competing failure modes will behave with changes in the specimen size was also studied.  Two groups of material each with two different specimen sizes were used in this study. It has been shown that the two crack initiation mechanisms occurred in the small  unseeded René 88DT specimens tested at 650ºC over the stress range tested. Additionally, the fatigue lives were reduced with increase in specimen volume.   All fatigue failures in seeded material occurred due to crack initiations from the seeded inclusions. In the fatigue life of seeded material, two competing and separate S-N curves were found in small test volume, whereas, in the large test volume, the regions  were separated by a "step" in S-N curve.  It has been found that the largest inclusion size observed in metallographic surfaces was smaller than the size determined from the fatigue failure origin. An analysis  method based on extreme value statistics developed by Murakami was used to predict the largest size of inclusion in the test volume.  The results of this study clearly show that competition for fatigue failure between surface and internal initiations is affected by inclusion content and specimen volume.  Extreme value statistics is capable of predicting the largest inclusion that can start fatigue failure, even if the inclusion is not seen in microscopy.
Structure and replication of Euglena gracills chloroplast DNA
Creators: name: Manning, Jerry Edsel
Publisher: name: University of Utah
Year: 2012
Subjects: Proteins
Phenotypes
DNA
Euglena gracilis
Mitochondria

description: The DNA molecule from chloroplasts of Euglena gracilis, strain Z, has been examined to determine (1) the structure and molecular weight of the molecule, (2) the mechanisms of replication of the molecule and (3) the ability of the molecule to replicate autonomously.  The chloroplasts were found to contain circular DNA molecules 44 mm in contour length corresponding to a molecular weight of 92 million daltons.  It was shown that the molecule replicated by a semiconservative mechanism with a half-life of 1.1 cell doublings.  Also, the DNA molecule could not be replicated in the absence of cytoplasmic protein synthesis, but could  be replicated in the absence of protein synthesis in the chloroplast.
Sonnenfleckenzeichnung Nr. 22783.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.05.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Novel activation of neutrophil functions
Creators: name: Feldhaus, Michael John
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Physiology
subject: FOS: Biological sciences

description: Chronic neutrophil activation results in severe tissue damage leading to loss of limb and life as illustrated from events ranging from adult respiratory distress syndrome (ARDS) to the inflammatory skin lesions associated with Staphylococcal and Streptococcal infections. Conversely, PMNs are critical for host protection, as individuals lacking functional PMNs, in the case of Leukocyte Adhesion Deficiency (LAD), neutropenia, and Chronic Granulomatous Disease (CGD), succumb to persistent bacterial infections. The efficacy of PMNs in host protection derives from their specialized functions. Activation of PMNs upregulates the quantity and affinity of their ?2-integrins with a concomitant loss of L-selectin. The quantitative increase in ?2-integrin upon activation is dependent upon fusion of intracellular granules containing ?2-integrin with the plasma membrane at the site of noxious insult. This also delivers proteases and essential components of the NADPH oxidase complex to the membrane that is necessary for efficient bacterial killing. This dissertation examines novel mechanisms of PMN activation. In the first study neutrophil activation is dissected into two distinct pathways. I demonstrate that sphingomyelinase C (SMC) treatment with the subsequent increase in the intracellular signaling molecule, ceramide, illuminates a bifurcation in PMN activation: ceramide induces degranulation and superoxide generation in the absence of increased ?2-integrin function. SMC induces an increase in ?2-integrin surface expression but, unusually, the integrin is maintained in a low affinity state. This correlates with in vivo data showing SMC mediates dysfunctional PMN sequestration within the vasculature. In the second study I show ICAM-3 engagement by specific epitope-mapped antibodies induces cytoskeletal dependent functional upregulation of the ?2-integrins. Signaling through this adhesion molecule in leukocytes was previously poorly defined. We demonstrate phosphorylation events by PKC and tyrosine kinases of several proteins after engagement, whereas inhibitors of these kinases result in inhibition of the signal emanating from ICAM-3. In the final study, data are presented illustrating that oncostatin M is a proinflammatory cytokine whose effects are mediated through activation of endothelium. In conclusion, these studies illustrate the complex regulation of PMN activation by defining diverse signaling pathways resulting in activation of specific effector functions.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität nach einer Projektion vom 13.04.1968, erstellt von Max Waldmeier am Astrophysikalischen Observatorium Tschuggen in Arosa.
Zusätzlich ist vermerkt: Coudé
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung am Astrophysikalischen Observatorium Tschuggen in Arosa. Instrument: Coudé-Refraktor (15 cm Öffnung und 225 cm Brennweite, projiziertes Sonnenbild D = 25 cm). - Instrumentennachweis gemäss Tätigkeitsber. für das vorhergehende Jahr, S. 1.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt
Symplectic 3-Algebras and D=3, N=4,5,6,8 superconformal Chern-Simons-Matter theories
Creators: name: Chen, Famin
Publisher: name: University of Utah
Year: 2012
Subjects: Symplectic
Algebras
Superconformal
Chern-Simons-matter theories, CSM theories
Lie algebras

description: M-theory is the underlying theory of  five di fferent string theories and 11D supergravity theory. While strings (1+1D) are fundamental objects in string theory, M2-branes (1+2D) are fundamental objects in M-theory. According to the Gauge/Gravity duality, a gravity  theory is equivalent to a gauge theory. Extended (N ? 4) superconformal Chern-Simonsmatter (CSM) theories in 3D are natural candidates of the dual gauge theories of multi M2-branes. In the last two years, the N = 4; 5; 6 CSM theories were constructed by using ordinary Lie 2-algebras, and the N = 8 theory was constructed by using 3-algebra. However, it remains unclear whether these theories can be constructed in a uni ed 3-algebra approach or not. It is also natural to ask whether there are new examples of the extended superconformal CSM theories. In this thesis, we propose to solve these two problems. We de fine a 3-algebra with structure constants being symmetric in the fi rst two indices. We also introduce an invariant antisymmetric tensor into this 3-algebra and call it a symplectic 3-algebra. The D = 3;N = 4; 5; 6; 8 CSM theories are constructed in terms of this unifi ed 3-algebraic structure, and some new examples of the N = 4 quiver gauge theories are derived as well. In particular, in order to realize the 3-algebra used to construct the N = 4 quiver gauge theories, we `fuse' two simple super Lie algebras into a single new super Lie algebra, by requiring that the even parts of these two simple super Lie algebras share one simple factor. We demonstrate how to construct this class of new super Lie algebras by presenting an explicit example. Finally, a quantization scheme for the 3-brackets is proposed.
Sonnenfleckenzeichnung Nr. 22848.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.07.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Isonychus paranus Moser 1921
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Melolonthidae
Isonychus
Isonychus paranus

description: Isonychus paranus Moser, 1921
Isonychus paranus Moser 1921b: 159 (Brazil)
Distribution. “Guianas”: Frey 1970: 137. Brazil: Moser 1921b: 159; Blackwelder 1944: 231; Evans and Smith 2009: 244.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 112, DOI: 10.5281/zenodo.3678492
Isonychus soricinus Blanchard 1850
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Melolonthidae
Isonychus
Isonychus soricinus

description: § Isonychus soricinus Blanchard, 1850
Isonychus soricinus Blanchard 1850: 85 (Brazil)
Distribution. Brazil (NA): Blanchard 1850: 85; Dalla Torre 1913: 237; Blackwelder 1944: 231; Frey 1970: 131 (NA); Evans and Smith 2009: 246.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 112, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung Nr. 22828.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.06.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Burden of illness of progressive familial intrahepatic cholestasis in the US, UK, France, and Germany: study rationale and protocol of the PICTURE study
Creators: name: Ruiz-Casas, Leonardo
name: O’Hara, Sonia
name: Mighiu, Claudia
name: Finnegan, Alan
name: Taylor, Alison
name: Ventura, Emily
name: Dhawan, Anil
name: Murray, Karen F
name: Schattenberg, Jorn
name: Willemse, Jose
name: Karakaidos, Melanie
name: Brrang, Harpreet
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Background: Progressive familial intrahepatic cholestasis (PFIC) is an ultra-rare disease with a considerable burden on pediatric patients and their caregivers, impacting quality of life (QoL). The mortality rates highlight a significant need for efficacious treatments. Real-world data on associated costs and QoL are needed to gauge the potential impact of new pharmacological treatments. Methods: Clinical and socio-economic burden of PFIC on patients/caregivers, health systems, and society will be assessed. Patient/caregiver- and physician-level retrospective cross-sectional data will be collected from the US, UK, France, and Germany, for PFIC types 1, 2, 3. A representative sample of physicians will provide clinical and resource utilization information using an electronic Case Report Form (eCRF). Patient/caregiver surveys will collect socio-economic and QoL data, enabling assessment of PFIC impact on QoL. Mean costs (direct medical/non-medical, indirect) will be calculated. The study materials were reviewed by medical professionals and patient representatives and received ethical approval from the University of Chester. Discussion: The study aims to reveal the unmet medical need, disease burden, resource utilization, and costs of PFIC, to raise awareness with policymakers and healthcare professionals, and provide support for the patient/caregiver community. As novel PFIC therapies recently emerged, this study will yield quantifiable data for health technology assessments.
Sonnenfleckenzeichnung Nr. 22808.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.06.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Productivity loss/gain in cost-effectiveness analyses for vaccines: a systematic review
Creators: name: Yuasa, Akira
name: Yonemoto, Naohiro
name: LoPresti, Michael
name: Ikeda, Shunya
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Introduction: The kinds of costs included in cost-effectiveness analyses (CEAs) for vaccines, such as direct medical costs and indirect costs, may affect their outcomes. While some guidelines recommend inclusion of costs associated with productivity losses/gains, very little guidance is provided about the productivity elements to include and their calculation approach. Areas covered: We conducted a systematic review of CEAs for vaccines and vaccine programs published between 1 January 2010 and 19 November 2019 that included productivity costs using Medline, Embase, and the Cochrane Library. The kind of productivity elements included their calculation approach, and the impact of their inclusion on cost-effectiveness are summarized. Among 88 studies identified, productivity elements included were reported for 71 studies (81%) with absenteeism being the most commonly included element. Only 24 studies (27%) reported the approach used to calculate productivity costs (human capital vs. friction approach). Most studies (81%) reported a more favorable cost-effectiveness with the inclusion of productivity losses/gains. Expert opinion: Inclusion of productivity losses/gains for CEAs for vaccines has resulted in more favorable cost-effectiveness based on the studies reviewed. However, clearer guidance on the productivity elements to include by disease area and more transparency on the calculation method used may be needed.
Paulosawaya Martinez and Andretta 1956
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Paulosawaya

description: PAULOSAWAYA Martínez and Andretta, 1956
Paulosawaya Martínez and Andretta 1956: 346
Note. The genus Paulosawaya is erected by Martínez and Andretta (1956: 346), synonymized with Clavipalpus Laporte, 1832 (p. 406) by Smith (2008: 22) and resurrected by Fuhrmann and Vaz-de-Mello (2017: 40).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 113, DOI: 10.5281/zenodo.3678492
Primary caregivers at home: relationship between the older Americans resources and services assessed functional levels of the caregiver and care receiver spouse dyad
Creators: name: McReynolds, Nancy E.
Publisher: name: University of Utah
Year: 2012
Subjects: Older people - Home care - United States

description: The Older Americans Resources and Services (OARS) Multidimensional Functional Assessment Questionnaire (OMFAQ) was administered to 20 spouse dyads.  In this study, one spouse was the primary informal caregiver for the other impaired spouse who was receiving home health care services. The data were subjected to descriptive and correlation analyses to address two questions:  (a) is there a relationship between the caregivers' and care receivers' functional status, and (b) is the caregiver even more impaired than the care receiver in any of the five dimensions measured by the OMFAQ?  The correlation matrix examining the relationship between the caregivers' and care receivers' assessment scores suggested (a) a positive relationship between caregivers' and care receivers' social resources, (b) a positive relationship between caregivers' mental health and care receivers' social resources, and (c) no relationship between caregiver functional status and care receiver indices of illness.  A comparison of the mean scores suggested that the caregiver was more impaired than the care receiver only in the area of social resources.
Glutaminase inhibitory activities of pentacyclic triterpenes isolated from Thymus vulgaris L.
Creators: name: Shimada, Atsumi
name: Ueno, Hiroshi
name: Inagaki, Masanori
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Glutaminase is an important target that is often over expressed in neurodegenerative and lifestyle related diseases but few effective inhibitors of this enzyme have yet reached clinical trials. Ursolic acid (1), betulinic acid (2) and oleanolic acid (3), three pentacyclic triterpene acids, have been isolated from the leaves of Thymus vulgaris L. Enzyme inhibition experiments demonstrated their inhibitory effects against glutaminase activity. Compound 2 significantly inhibited the glutaminase activity with IC50 of 0.31 mM, stronger than the positive control 6-diazo-5-oxo-L-norleucine (DON) with IC50 of 0.57 mM. Compound 2 may serve as a potential lead compound for the prevention and treatment of neurodegenerative diseases and lifestyle related diseases by targeting glutaminase. This is the first report on glutaminase inhibitory activities of 1-3 isolated from T. vulgaris L.
Isonychus striolatus Frey 1970
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Melolonthidae
Isonychus
Isonychus striolatus

description: Isonychus striolatus Frey, 1970
Isonychus striolatus Frey 1970: 141 (Mt Roraimo [= Mt Roraima Brazil? (NA) / = Mt Roraima Venezuela? (EO) / = Mt Roraima Guyana?])
Distribution. Brazil: Evans and Smith 2009: 246. Other: Frey 1970: 141 (see note).
Note. Frey (1970: 141) gives as the type locality of Isonychus striolatus only Mt. Roraima, which is the tristate border point of Guyana, Brazil and Venezuela. Evans and Smith (2009: 246) place the location in Brazil. However, only about five percent of Mt. Roraima is within Brazil, while about 10 and 85 percent is within the territories of, respectively, Guyana and Venezuela. The actual type locality may be in either one of those countries and might be revealed by studying the diaries of the expedition on which the type specimens were found.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 112, DOI: 10.5281/zenodo.3678492
Comparison of sensitivity to a commercial Origanum vulgare essential oil between extended-spectrum β-lactamases (ESBL-) and non-ESBL-producing Enterobacteriaceae isolates
Creators: name: Benameur, Qada
name: Gervasi, Teresa
name: Pellizzeri, Vito
name: Pľuchtová, Mária
name: Gruľová, Daniela
name: Cicero, Nicola
name: Meriem-Hind, Benmahdi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: This study aimed to evaluate the antibacterial effect of Origanum vulgare essential oil (OVEO) against ESBL- and non-ESBL-producing multidrug-resistant (MDR) Enterobacteriaceae isolates. OVEO composition was determined using Gas chromatograph-mass spectrometer (GC/MS). In the current study, the effect of OVEO was studied on seven MDR Enterobacteriaceae isolates. Antibacterial activity of OVEO was investigated by the disc diffusion assay and twofold serial dilution method. GC/MS analysis identified thymol (78.21%) as the single major component present in the OVEO. This EO showed an unexpectedly high antibacterial activity against all the studied MDR Enterobacteriaceae isolates, with inhibition zone diameters and minimum inhibitory concentration (MIC) values ranging from 28 ± 0.6 to 35 ± 0.6 mm and 0.31 ± 0.0 to 5 ± 0.0 μL/mL, respectively. However, ESBL-producing isolates were more susceptible to OVEO than non-ESBL producing isolates. This study compared, for the first time, the sensitivity to OVEO between ESBL and non-ESBL-producing Enterobacteriaceae isolates.
Sonnenfleckenzeichnung Nr. 22821.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.06.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Heuristics for efficient dynamic verification of message passing interface and thread programs
Creators: name: Chiang, Wei-Fan
Publisher: name: University of Utah
Year: 2012
Subjects: Dynamic verification
Heuristic
MPI programs
Thread programs

description: Concurrent programs are extremely important for efficiently programming future HPC systems. Large scientific programs may employ multiple processes or threads to run on HPC systems for days. Reliability is an essential requirement of existing concurrent programs. Therefore, verification of concurrent programs becomes increasingly important. Today we have two significant challenges in developing concurrent program verification tools: The first is scalability. Since new types of concurrent programs keep being created, verification tools need to scale to handle all these new types of programs. The second is providing formal coverage guarantee. Dynamic verification tools always face a huge schedule space. Both these capabilities must exist for testing programs that follow multiple concurrency models.  Most current dynamic verification tools can only explore either thread level or process level schedules. Consequently, they fail to verify hybrid programs. Exploring mixed process and thread level schedules is not an ideal solution because the state space will grow exponentially in both levels. It is hard to systematically traverse these mixed schedules. Therefore, our approach is to determinize all concurrent APIs except one API whose schedules will then be explored.   To improve search efficiency, we proposed a random-walk based heuristic algorithm. We observed many concurrent programs and concluded some common structures of them. Based on the existence of these structures, we can make dynamic verification  tools focusing on specific regions and bypassing regions of less interest. We propose a random sampling of executions in the regions of less interest.
Sonnenfleckenzeichnung Nr. 22820.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.06.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
The scalability of parallel adaptive mesh refinement within Uintah
Creators: name: Luitjens, Justin Paul
Publisher: name: University of Utah
Year: 2012
Subjects: Adaptive mesh refinement
Load balancing
Parallel
Regridding
Scalability
Simulation
Uintah

description: Solutions to Partial Di erential Equations (PDEs) are often computed by discretizing the domain into a collection of computational elements referred to as a mesh. This solution is an approximation with an error that decreases as the mesh spacing decreases. However, decreasing the mesh spacing also increases the computational requirements. Adaptive mesh re nement (AMR) attempts to reduce the error while limiting the increase in computational requirements by re ning the mesh locally in regions of the domain that have large error while maintaining a coarse mesh in other portions of the domain. This approach often provides a solution that is as accurate as that obtained from a much larger  xed mesh simulation, thus saving on both computational time and memory. However, historically, these AMR operations often limit the overall scalability of the application. Adapting the mesh at runtime necessitates scalable regridding and load balancing algorithms. This dissertation analyzes the performance bottlenecks for a widely used regridding algorithm and presents two new algorithms which exhibit ideal scalability. In addition, a scalable space- lling curve generation algorithm for dynamic load balancing is also presented. The performance of these algorithms is analyzed by determining their theoretical complexity, deriving performance models, and comparing the observed performance to those performance models. The models are then used to predict performance on larger numbers of processors. This analysis demonstrates the necessity of these algorithms at larger numbers of processors. This dissertation also investigates methods to more accurately predict workloads based on measurements  taken at runtime. While the methods used are not new, the application of these methods to the load balancing process is. These methods are shown to be highly  accurate and able to predict the workload within 3% error. By improving the accuracy of these estimations, the load imbalance of the simulation can be reduced, thereby increasing the overall performance.
Brief an [Johann III] Bernoulli
Creators: name: Segner, Johann Wilhelm von
Publisher: name: [s.n.]
Year: 1784

description: von J[ohann] W[ilhelm] [Andreas] v. Segner
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Isonychus variegatus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Melolonthidae
Isonychus
Isonychus variegatus

description: § Isonychus variegatus (Germar, 1824)
Melolontha variegata Germar 1824: 128 (Brazil)
= Melolontha deglupta Germar 1824: 623 (Brazil)
= Colporhina bifoveolata Curtis 1844: 200 (Brazil)
Distribution. Guyana: Bodkin 1919: 214 (as Barybas bifoveolatus). Brazil: Germar 1824: 128, 623 (as Melolontha deglupta; as Melolontha variegata); Curtis 1845: 454 (as Colporhina bifoveolata); Dalla Torre 1913: 327; Blackwelder 1944: 231; Frey 1970: 135; Evans and Smith 2009: 248. Other: Curtis 1844: 200 (none - as Colporhina bifoveolata).
Note 1. Germar (1824) gives in the Corrigenda (p. 623) the replacement name Melolontha deglupta because of his M. variegata being a junior homonym of M. variegata Latreille, 1813 (p. 47). Melolonta deglupta Germar, 1824 is now considered a synonym of Isonychus variegatus (Germar, 1824), while M. variegata Latreille, 1813 is now treated as a synonym of Anomala undulata brasiliensis (Arrow, 1899) (1899a, p. 272). When establishing the latter synonymization, Arrow (1899a) was possibly assuming that Latreille’s description was published in 1833, while it was in fact published already in 1813 (see Sherborn 1899: 428). Given that Latreille’s description is thus older than that of A. variegata Hope, 1831 (p. 24), the seniority in this synonymization may have to be reversed. We have not further investigated this complex matter, but it seems imperative that this has to be done in the near future.
Note 2. Curtis (1844: 200) gives a very short description and no distributional data of Colporhina bifoveolata. Curtis (1845: 454) provides a more extensive description and the type locality.
Note 3. Bodkin (1919: 214) records Isonychus variegatus from Guyana. However, all other records we are aware of are from Brazil south of the Amazon River. We assume the record in Bodkin (1919) is based on a misidentified specimen and regard this species as not occurring in the research area.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 112-113, DOI: 10.5281/zenodo.3678492
Characterization of speciated atmospheric mercury concentration measurements in Northern Utah
Creators: name: Maestas, Melissa May
Publisher: name: University of Utah
Year: 2012
Subjects: GEM
GOM
Atmospheric mercury
PBM
Northern Utah

description: Two years of speciated atmospheric mercury data in the Intermountain West are examined for annual, seasonal, and diurnal patterns, as well as influences of precipitation. Mercury is a pollutant in the atmosphere that occurs as three species: gaseous elemental mercury  (GEM), particulate-bound mercury (PBM), and gaseous oxidized mercury (GOM). Mercury can enter ecosystems from the atmosphere via wet and dry deposition. In aquatic ecosystems, it can convert to the neurotoxin methylmercury, which has prompted consumption advisories for both fish and waterfowl. A Tekran ambient air mercury monitor was deployed at a site (UT96) near the Great Salt Lake, Utah as part of the Atmospheric Mercury Network (AMNet). UT96 has the only such detector in continuous operation in Utah with two years of data (July 2009 - June 2011).  All three mercury species exhibit right-skewed distributions and vary in concentration over multiple orders of magnitude. GEM is the dominant species with a median concentration of 1.58 ng m-3 (range 0.25 - 64.47 ng m-3). PBM has a median concentration of 5.7  pg m-3 (range 0 - 803.2 pg m-3), while GOM has a    median concentration of 2.6 pg m-3 (range 0 - 225.6 pg m-3). The sporadic nature of the extremely high GEM and PBM events suggest that they primarily result from local/regional emissions. In contrast, extremely  high GOM events depend strongly on time of day and season, suggesting a connection to meteorological conditions.  All three species exhibit statistically significant seasonal and diurnal patterns. GOM exhibits the strongest seasonal pattern, peaking during summer with median summer concentrations a factor of six greater than median winter concentrations. GEM and PBM peak  during winter. All three species exhibit statistically significant diurnal patterns for at least part of the year. GOM has the most pronounced diurnal cycle, particularly during summer.Median concentrations of GOM during the afternoons of summer months are greater than 20 pg m-3, while median concentrations overnight are below 5 pg m-3.  GEM and PBM both exhibit minima in concentrations during the afternoons, and both exhibit the largest diurnal variation amplitude during summer. Neither GEM nor PBM exhibit a statistically significant diurnal pattern during winter.  An examination of the influences of precipitation on mercury concentrations indicates that precipitation scavenges GOM more efficiently than PBM, and that the scavenging increases as the amount of precipitation increases. Mixed precipitation scavenges PBM better  than either rain or snow alone. The median GOM concentration during rain, snow, and mixed precipitation were all below the method detection limit (MDL), and could not be distinguished. There are some indications in the data that rain may promote slightly elevated concentrations of GEM.
Family medicine and the predoctoral medical curriculum
Creators: name: Jarvis, Joseph Q.
Publisher: name: University of Utah
Year: 2012
Subjects: Family medicine - Study and teaching
Premedical education

description: Family medicine faculty at medical school throughout the United States have stated that their specialty should be recognized as a required part of the predoctoral medical curriculum.  Other medical faculty members have expressed disagreement.  Support for family medicine as an integral part of medical education can be found in several sources; among the are "Medical Education in the United States and Canada," the so-called "Flexner Report," and "Physicians for the 21st Century" also know as the GPEP report.  A survey of deans of U.S. medical schools and department chairs of family medicine at the same schools highlights the divergent views of the place of family medicine in predoctoral medical education.  Family medicine faculty must convincingly argue that medical education should no be limited to an information transfer process before they will succeed in having family medicine recognized as a required part of education
Geology of the Wanship - Park City Region, Utah
Creators: name: Mount, Donald Lee
Publisher: name: University of Utah
Year: 2012
Subjects: Geology -- Utah -- Summit County
Thesis and dissertation georeferencing project

description: The author wishes to express his sincere appreciation to Norman C. Williams of the University of Utah, upon whose suggestion this problem was undertaken.c His supervision and assistance in the field and in the preparation of the manuscript proved invaluable. Thanks are due Armand J. Eardley, William Lee Stokes, and F. W. Christiansen of the University of Utah for their aid on specific problems within the area and for their helpful counsel.
Brief an [Johann Heinrich Lambert]
Creators: name: Schönberg, Kurt Friedrich von
Publisher: name: [s.n.]
Year: 1775

description: von Curt Friedrich von Schönberg
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Druck: Lambert, Johann Heinrich. - Joh. Heinrich Lamberts deutscher gelehrter Briefwechsel / herausg. von Joh. Bernoulli. - Berlin, 1782, 2, S.307-310
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Certified nurse-midwives in private practice: a descriptive study
Creators: name: Ellis, Deborah Marie
Publisher: name: University of Utah
Year: 2012
Subjects: Midwives

description: A descriptive study was conducted, consisting of written surveys mailed to private practices of Certified Nurse-Midwives, and follow-up with personal interviews with some of the respondents. The purpose of the study was to determine some characteristics of nurse-midwives' private practices, and to enumerate factors which serve as facilitators and barriers to private practice. Results indicate that one-third of the respondents feel that private nurse-midwifery practice will continue to grow. On a scale where 100 = extremely satisfied with private practice, the mean level of satisfaction was 75. Statistically significant correlations were obtained (p = $
Prostaglandin-releasing hydrogels for peptic ulcer disease
Creators: name: Mack, Eric Joseph
Publisher: name: University of Utah
Year: 2012
Subjects: Gels
Pharmacology
Drug Therapy

description: An oral polymeric drug delivery system for the release of prostaglandin F2alph (PGF2alph) is developed fro the induction of cytoprotection.  Prostaglandins, in doses one-tenth that of amounts that cause adverse effects, induce the mucosa to be reinforced against ulcerogenic stimuli.  The polymeric materials used are hydrogel copolymers of 2-hydroxyethyl methacrylate (HEMA) and related comonomers or HEMA and poly(tetramethylene oxide).   When the copolymer discs are placed in prostaglandin hydroalcoholic solutions, the swelling hydrogel absorbs drug along with the solvent into the polymer network.  Evaporation of solvent leaves drug trapped within a dried hydrogel matarix.  Quantitation of drug payloads show maximal drug loading in the range of 0.1 to 1.1 % dried hydrogel weight occurring after 8 to 12 hours absorption time.  Upon exposure to aqueous media, release of prostaglandin from the hydrogel is in response to dissolution of the drug by a advancing solvent front.  Release profiles show an initial lag time possible due to the slow rate of release media flow through the in vitro system.  Use of an agitation-type system decreases the lag time seen significantly.  The lag time can be obviated by ionically bonding prostaglandin carboxylate anion to a charged quaternary ammonium hydrogel surface.  Exposure to simulated gastric fluid causes immediate release of prostaglandin from the surface of up to 3 mg drug in four hours.  Release of prostaglandin entrapped within the hydrogel matrix ranges from 5-30% of initial drug payload in the initial four hour period.  In vivo release of prostaglandin from hydrogel rods is studied by introducing loaded, dried rods into Dprague-Dawley rats.  Drug release of 38% of initial payload occurs in five hours and 67% of initial payload in a eight hour period, similar to results found in vitro rod studies.  The results obtained from swelling-loaded and surface-loaded prostaglandin experiments will provide insight into development of an oral hydrogel prostaglandin-releasing delivery system for in vivo induction of cytoprotection utilizing minimum amounts of prostaglandin.