cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Safety of baricitinib for the treatment of atopic dermatitis over a median of 1.6 years and up to 3.9 years of treatment: an updated integrated analysis of eight clinical trials
Creators: name: Bieber, Thomas
name: Katoh, Norito
name: Simpson, Eric L.
name: de Bruin-Weller, Marjolein
name: Thaçi, Diamant
name: Torrelo, Antonio
name: Sontag, Angelina
name: Grond, Susanne
name: Issa, Maher
name: Lu, Xiaoyu
name: Cardillo, Tracy
name: Holzwarth, Katrin
name: Thyssen, Jacob P.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Baricitinib, a selective Janus kinase (JAK)1/JAK2 inhibitor, is approved for treatment of moderate-to-severe atopic dermatitis (AD) in adults. We report integrated baricitinib safety data in patients with up to 3.9-years exposure. Three datasets from the integrated AD clinical trial program were analyzed: placebo-controlled, 2-mg–4-mg extended, and All-bari. Data cutoffs were up to 21-December-2021 for long-term extension studies. Proportions of patients with events and incidence rates (IR)/100 patient years (PY) at risk were calculated. 2636 patients received baricitinib for 4628.4 PY. Discontinuation due to adverse events was low (IR = 3.4). IRs in All-bari were: serious adverse events, 5.2; infection, 67.2 (any infection), 6.7 (herpes simplex), 2.8 (herpes zoster), and 0.3 (opportunistic infections). Adverse events of special interest in All-bari included seven patients with positively adjudicated major adverse cardiovascular events (MACE) (IR = 0.15), three pulmonary emboli (PE) (IR = 0.06), 14 malignancies excluding nonmelanoma skin cancer (IR = 0.3), one gastrointestinal perforation (IR = 0.02), and four deaths (IR = 0.1). No deep vein thromboses (DVT) or tuberculosis were reported. In this analysis, baricitinib maintained a similar safety profile to earlier analyses with no new safety signals. Rates of MACE, DVT/PE, malignancies, and serious infections were within ranges of background rates in patients with AD. NCT02576938 (JAHG), NCT03334396 (JAHL; BREEZE-AD1), NCT03334422 (JAHM; BREEZE-AD2), NCT03334435 (JAHN; BREEZE-AD3), NCT03428100 (JAIN; BREEZE-AD4), NCT03435081 (JAIW; BREEZE-AD5), NCT03559270 (JAIX; BREEZE-AD6), NCT03733301 (JAIY; BREEZE-AD7)
Nontrivial solutions of quasilinear elliptic equations with natural growth term
Creators: name: Degiovanni, Marco
name: Pluda, Alessandra
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35J66, 47H11

description: We prove the existence of multiple solutions for a quasilinear elliptic equation containing a term with natural growth, under assumptions that are invariant by diffeomorphism. To this purpose we develop an adaptation of degree theory.
description: 25 pages
Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans
Creators: name: Zeen Tong
name: Atsriku, Christian
name: Yerramilli, Usha
name: Xiaomin Wang
name: Li, Yan
name: Reyes, Josephine
name: Fan, Bin
name: Yang, Hua
name: Hoffmann, Matthew
name: Surapaneni, Sekhar
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: 1. The absorption, distribution, metabolism and excretion of enasidenib were studied following a single oral dose of [14C]enasidenib to rats (10 mg/kg; 100 μCi/kg) and healthy volunteers (100 mg; 318 nCi). 2. Enasidenib was readily absorbed, extensively metabolized and primarily eliminated via the hepatobiliary pathway. Enasidenib-derived radioactivity was widely distributed in rats. Excretion of radioactivity was approximately 95–99% of the dose from rats in 168 h post-dose and 82.4% from human volunteers in 504 h post-dose. In rat bile, approximately 35–42% of the administered dose was recovered, with less than 5% of the dose excreted as the parent drug. Renal elimination was a minor pathway, with <12% of the dose excreted in rat urine and <10% of the dose excreted in human urine. 3. Enasidenib was the prominent radioactive component in rat and human systemic circulation. Enasidenib was extensively metabolized in rats and human volunteers through N-dealkylation, oxidation, direct glucuronidation and combinations of these pathways. Glucuronidation was the major metabolic pathway in rats while N-dealkylation was the prominent metabolic pathway in human volunteers. All human metabolites were detected in rats.
Contact enhancement of locomotion in spreading cell colonies
Creators: name: d'Alessandro, Joseph
name: Solon, Alexandre P.
name: Hayakawa, Yoshinori
name: Anjard, Christophe
name: Detcheverry, François
name: Rieu, Jean-Paul
name: Rivière, Charlotte
Publisher: name: arXiv
Year: 2017
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Cell Behavior (q-bio.CB)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The dispersal of cells from an initially constrained location is a crucial aspect of many physiological phenomena ranging from morphogenesis to tumour spreading. In such processes, the way cell-cell interactions impact the motion of single cells, and in turn the collective dynamics, remains unclear. Here, the spreading of micro-patterned colonies of non-cohesive cells is fully characterized from the complete set of individual trajectories. It shows that contact interactions, chemically mediated interactions and cell proliferation each dominates the dispersal process on different time scales. From data analysis and simulation of an active particle model, we demonstrate that contact interactions act to speed up the early population spreading by promoting individual cells to a state of higher persistence, which constitutes an as-yet unreported contact enhancement of locomotion. Our findings suggest that the current modeling paradigm of memoryless interacting active particles may need to be extended to account for the possibility of internal states and history-dependent behaviour of motile cells.
Charged String Tensor Networks
Creators: name: Biamonte, Jacob
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Tensor network methods provide an intuitive graphical language to describe quantum states, channels, open quantum systems and a class of numerical approximation methods that efficiently simulate certain many-body states in one spatial dimension. There are two fundamental types of tensor networks in wide use today. The most common is similar to quantum circuits. The second is the braided class of tensor networks, used in topological quantum computing. Recently a third class of tensor networks was discovered by Jaffe, Liu and Wozniakowski---the JLW-model---notably, the wires carry charge excitations. The rules in which network components can be moved, merged and manipulated in a graphical form of reasoning take an elegant form. For instance the relative charge locations on wires carries precise meaning and changing the ordering modifies a connected network specifically by a complex number. The type of isotopy discovered in the topological JLW-model provides an alternative means to reason about quantum information, computation and protocols. Here we recall the tensor-network building blocks used in a controlled-NOT gate. Some open problems related to the JLW-model are given.
description: published version + significance statement/abstract
Globular cluster formation with multiple stellar populations from hierarchical star cluster complexes
Creators: name: Bekki, Kenji
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Most old globular clusters (GCs) in the Galaxy are observed to have internal chemical abundance spreads in light elements. We discuss a new GC formation scenario based on hierarchical star formation within fractal molecular clouds. In the new scenario, a cluster of bound and unbound star clusters (`star cluster complex', SCC) that have a power-law cluster mass function with a slope (beta) of 2 is first formed from a massive gas clump developed in a dwarf galaxy. Such cluster complexes and beta=2 are observed and expected from hierarchical star formation. The most massive star cluster (`main cluster'), which is the progenitor of a GC, can accrete gas ejected from asymptotic giant branch (AGB) stars initially in the cluster and other low-mass clusters before the clusters are tidally stripped or destroyed to become field stars in the dwarf. The SCC is initially embedded in a giant gas hole created by numerous supernovae of the SCC so that cold gas outside the hole can be accreted onto the main cluster later. New stars formed from the accreted gas have chemical abundances that are different from those of the original SCC. Using hydrodynamical simulations of GC formation based on this scenario, we show that the main cluster with the initial mass as large as [2-5]x10^5 Msun can accrete more than 10^5 Msun gas from AGB stars of the SCC. We suggest that merging of hierarchical star cluster complexes can play key roles in stellar halo formation around GCs and self-enrichment processes of GCs.
description: 19 pages, 10 figures, MNRAS in press
Absorption, Distribution, Metabolism and Excretion of an Isocitrate Dehydrogenase-2 Inhibitor Enasidenib in Rats and Humans
Creators: name: Zeen Tong
name: Atsriku, Christian
name: Yerramilli, Usha
name: Xiaomin Wang
name: Li, Yan
name: Reyes, Josephine
name: Fan, Bin
name: Yang, Hua
name: Hoffmann, Matthew
name: Surapaneni, Sekhar
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: 1. The absorption, distribution, metabolism and excretion (ADME) of enasidenib were studied following a single oral dose of [14C]enasidenib to rats (10 mg/kg; 100 μCi/kg) and healthy volunteers (100 mg; 318 nCi). 2. Enasidenib was readily absorbed, extensively metabolized and primarily eliminated via the hepatobiliary pathway. Enasidenib-derived radioactivity was widely distributed in rats. Excretion of radioactivity was approximately 95% to 99% of the dose from rats in 168 hours post-dose and 82.4% from human volunteers in 504 hours post-dose. In rat bile, approximately 35% to 42% of the administered dose was recovered, with less than 5% of the dose excreted as the parent drug. Renal elimination was a minor pathway, with < 12% of the dose excreted in rat urine and < 10% of the dose excreted in human urine. 3. Enasidenib was the prominent radioactive component in rat and human systemic circulation. Enasidenib was extensively metabolized in rats and human volunteers through N-dealkylation, oxidation, direct glucuronidation, and combinations of these pathways. Glucuronidation was the major metabolic pathway in rats while N-dealkylation was the prominent metabolic pathway in human volunteers. All human metabolites were detected in rats.
Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics
Creators: name: Cui, Jingwen
name: Zhang, Xiaomei
name: Deng, Jingwen
name: Yan, Yuhong
name: Yao, Danni
name: Deng, Hao
name: Yu, Jingjie
name: Ye, Shuyan
name: Han, Ling
name: Yu, Xiaobo
name: Lu, Chuanjian
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Psoriasis is a chronic skin disease, and topical sequential therapy with a combination of calcipotriol and calcipotriol betamethasone is currently approved topical treatment. However, the exact mechanism by which this treatment regimen relieves psoriasis is unknown. We assembled a cohort of 65 psoriasis patients and divided post-treatment cohort into responder group and non-responder group according to the Psoriasis Area Severity Index (PASI) score after 12-week treatment. We measured the expression levels of proteins in collected 130 serum samples using our in-depth proteomics platform with a data-independent acquisition mass spectrometer and antibody microarray. We performed bioinformatics analyses of the biologic processes and signaling pathways that were changed in the responder group and constructed a proteomics landscape of psoriasis pathogenesis response to treatment. We then validated the biomarkers of disease severity in an independent cohort of 88 samples using an enzyme-linked immunosorbent assay. We first identified 174 differentially expressed proteins (DEPs) for comparative analysis of proteins between responders and non-responders at baseline (p < 0.05). Then pathway analysis showed that the responders focused more on signaling molecules and interaction, complement and coagulation cascades, whereas the non-responders more on signal transduction and IL-17 signaling pathways. We further identified four candidate biomarkers (COLEC11, C1QA, BNC2, ITIH4) response to treatment. We also found 125 DEPs (p < 0.05) after treatment compared with before treatment in responder group. Pathway analysis showed an enrichment in pathways related to complement and coagulation cascades, phagosome, ECM-receptor interaction, cholesterol metabolism, vitamin digestion and absorption. CD14 was validated as potential biomarkers for the disease severity of psoriasis and treatment targets. In this work, we analyzed the response to topical sequential therapy and finally identified four biomarkers. Additionally, we found that topical sequential therapy may alleviate psoriasis by regulating lipid metabolism and modulating the immune response by affecting the complement activation process.
Cavity cooling of many atoms
Creators: name: Hosseini, Mahdi
name: Duan, Yiheng
name: Beck, Kristin M.
name: Chen, Yu-Ting
name: Vuletić, Vladan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We demonstrate cavity cooling of all motional degrees of freedom of an atomic ensemble using light that is far detuned from the atomic transitions by several gigahertz. The cooling is achieved by cavity-induced frequency-dependent asymmetric enhancement of the atomic emission spectrum, thereby extracting thermal kinetic energy from the atomic system. Within $100 ~\mathrm{ms}$, the atomic temperature is reduced from $200 ~μ\mathrm{K}$ to $10 ~μ\mathrm{K}$, where the final temperature is mainly limited by the linewidth of the cavity. In principle, the technique can be applied to molecules and atoms with complex internal energy structure.
Instabilities in Horndeski Yang-Mills inflation
Creators: name: Jimenez, Jose Beltran
name: Heisenberg, Lavinia
name: Kase, Ryotaro
name: Namba, Ryo
name: Tsujikawa, Shinji
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A non-abelian $SU(2)$ gauge field with a non-minimal Horndeski coupling to gravity gives rise to a de Sitter solution followed by a graceful exit to a radiation-dominated epoch. In this Horndeski Yang-Mills (HYM) theory we derive the second-order action for tensor perturbations on the homogeneous and isotropic quasi de Sitter background. We find that the presence of the Horndeski non-minimal coupling to the gauge field inevitably introduces ghost instabilities in the tensor sector during inflation. Moreover, we also find Laplacian instabilities for the tensor perturbations deep inside the Hubble radius during inflation. Thus, we conclude that the HYM theory does not provide a consistent inflationary framework due to the presence of ghosts and Laplacian instabilities.
description: 8 pages, 2 figures
Reduction and integrability: a geometric perspective
Creators: name: Cariñena, José F.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences
subject: 34A34, 37N05, 53C15

description: A geometric approach to integrability and reduction of dynamical system is developed from a modern perspective. The main ingredients in such analysis are the infinitesimal symmetries and the tensor fields that are invariant under the given dynamics. Particular emphasis is given to the existence of invariant volume forms and the associated Jacobi multiplier theory, and then the Hojman symmetry theory is developed as a complement to Noether theorem and non-Noether constants of motion. The geometric approach to Hamilton-Jacobi equation is shown to be a particular example of the search for related field in a lower dimensional manifold.
description: short review papaer
Sources of variation of the environmental impact of cereal-based intensive beef finishing herds
Creators: name: Berton, Marco
name: Cesaro, Giacomo
name: Gallo, Luigi
name: Ramanzin, Maurizio
name: Sturaro, Enrico
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: This study aimed to investigate the effect of beef category, feedstuffs self-sufficiency (SELF), crude protein (CPI) and phosphorus (PI) daily intake on the environmental impact of the beef fattening system typical of north-eastern Italy according to a partial Life Cycle Assessment. The reference unit was the batch (group of animals homogeneous for genotype, sex, fattening farm, finishing period). The study involved 245 batches (64 ± 34 heads) herded in 17 fattening farms. The system boundaries were set from animals arrival at the fattening farm to the sale to the slaughterhouse. The functional unit was 1 kg BW gain (BWG). Data on animal performance and farm input were collected for each batch and farm, respectively. Data on feed intake, ingredient formulation and chemical composition of diets were monthly collected for each batch. Impact categories assessed were (mean ± SD per kg BWG in brackets): global warming (8.8 ± 1.6 kg CO2-eq), acidification (142 ± 22 g SO2-eq) and eutrophication (55 ± 8 g PO4-eq) potentials, cumulative energy demand (53 ± 18 MJ), land occupation (7.9 ± 1.2 m2/year). Beef category and SELF, CPI and PI classes significantly affected all the impact categories, with lower values observed with decreasing values of CPI and PI and increasing values of SELF as well as more productive beef categories. This study evidences that beef category and diet-related factors affect the environmental impact of cereal-based intensive beef finishing herds. In conclusion, there is space to develop mitigation strategies based on enhancing the self-sufficiency rate of the diet and lowering the daily intake of crude protein and phosphorus.
Gamma-ray Observations Under Bright Moonlight with VERITAS
Creators: name: Archambault, S.
name: Archer, A.
name: Benbow, W.
name: Bird, R.
name: Bourbeau, E.
name: Bouvier, A.
name: Buchovecky, M.
name: Bugaev, V.
name: Cardenzana, J. V
name: Cerruti, M.
name: Ciupik, L.
name: Connolly, M. P.
name: Cui, W.
name: Daniel, M. K.
name: Errando, M.
name: Falcone, A.
name: Feng, Q.
name: Finley, J. P.
name: Fleischhack, H.
name: Fortson, L.
name: Furniss, A.
name: Gillanders, G. H.
name: Griffin, S.
name: Hanna, D.
name: Hervet, O.
name: Holder, J.
name: Hughes, G.
name: Humensky, T. B.
name: Hütten, M.
name: Johnson, C. A.
name: Kaaret, P.
name: Kar, P.
name: Kertzman, M.
name: Kieda, D.
name: Krause, M.
name: Lang, M. J.
name: Maier, G.
name: McArthur, S.
name: Moriarty, P.
name: Mukherjee, R.
name: Nieto, D.
name: O'Brien, S.
name: Ong, R. A.
name: Otte, A. N.
name: Park, N.
name: Pohl, M.
name: Popkow, A.
name: Pueschel, E.
name: Quinn, J.
name: Ragan, K.
name: Reynolds, P. T.
name: Richards, G. T.
name: Roache, E.
name: Rulten, C.
name: Sadeh, I.
name: Sembroski, G. H.
name: Shahinyan, K.
name: Staszak, D.
name: Telezhinsky, I.
name: Trepanier, S.
name: Wakely, S. P.
name: Weinstein, A.
name: Wilcox, P.
name: Williams, D. A.
name: Zitzer, B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Imaging atmospheric Cherenkov telescopes (IACTs) are equipped with sensitive photomultiplier tube (PMT) cameras. Exposure to high levels of background illumination degrades the efficiency of and potentially destroys these photo-detectors over time, so IACTs cannot be operated in the same configuration in the presence of bright moonlight as under dark skies. Since September 2012, observations have been carried out with the VERITAS IACTs under bright moonlight (defined as about three times the night-sky-background (NSB) of a dark extragalactic field, typically occurring when Moon illumination > 35%) in two observing modes, firstly by reducing the voltage applied to the PMTs and, secondly, with the addition of ultra-violet (UV) bandpass filters to the cameras. This has allowed observations at up to about 30 times previous NSB levels (around 80% Moon illumination), resulting in 30% more observing time between the two modes over the course of a year. These additional observations have already allowed for the detection of a flare from the 1ES 1727+502 and for an observing program targeting a measurement of the cosmic-ray positron fraction. We provide details of these new observing modes and their performance relative to the standard VERITAS observations.
Additional file 2 of The People’s Trial: supporting the public’s understanding of randomised trials
Creators: name: Finucane, Elaine
name: O’Brien, Ann
name: Treweek, Shaun
name: Newell, John
name: Das, Kishor
name: Chapman, Sarah
name: Wicks, Paul
name: Galvin, Sandra
name: Healy, Patricia
name: Biesty, Linda
name: Gillies, Katie
name: Noel-Storr, Anna
name: Gardner, Heidi
name: O’Reilly, Mary Frances
name: Devane, Declan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2.
English language teachers’ perceptions and the impact of a standardised professional development program in Sabah, Malaysia: a mixed methods study
Creators: name: Hiew, Wendy
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Professional development of language teachers can be of enormous benefit if conducted in an effective way, but can sometimes result in unsatisfactory outcomes and sub-optimal use of resources. This study investigates EFL teachers’ perceptions and the impact of the ProELT (Professional Up-skilling of English Language Teachers) which was a nationwide, one-year program designed and conducted by the British Council Malaysia. A review of previous studies revealed a paucity of research focusing on large scale, standardised teacher professional development programs that involved participation of EFL teachers from both heterogeneous teaching levels (i.e. primary and secondary schools) and heterogeneous districts (i.e. urban and rural). The limited published studies available have been critical of this mode of professional development for a number of reasons, and the purpose of this study was to investigate these issues in the Malaysian context. A mixed methods explanatory sequential design was adopted, which utilised a questionnaire survey, interviews and focus groups with the teachers and District English Language Officers (DELOs), and a coursebook content analysis. Four major weaknesses of the ProELT were identified. First, the selection method of the program participants was ineffective because it did not align with the program objectives. The selection was based solely on a measure of the participants’ language proficiency, but no attempt was made to assess the teachers’ instructional competency. It resulted in the experienced teachers feeling dissatisfied that their teaching experiences were disregarded and some of them were negatively and emotionally affected. In addition, the standardised program coursebook was mostly irrelevant to the teachers’ curriculum specifications, with the outcome that the majority of the teachers interviewed failed to implement the program resources in their lessons. Finally, there was no follow-up from the program trainers in the form of classroom observations and visits, and meetings, amongst others, at the end of the program. Participants also reported a lack of support and communication from the Malaysian Ministry of Education who was the program provider. The findings of the study further problematise the application of standardised or “one-size-fits-all” professional development programs in the EFL context in the developing world such as Malaysia which places high emphasis on enhancing teachers’ and students’ English proficiency by allocating RM135 million (AUD44 million) for English language enhancement programs, and have theoretical and practical implications for PD on a broader scale.
Quantifying Search Bias: Investigating Sources of Bias for Political Searches in Social Media
Creators: name: Kulshrestha, Juhi
name: Eslami, Motahhare
name: Messias, Johnnatan
name: Zafar, Muhammad Bilal
name: Ghosh, Saptarshi
name: Gummadi, Krishna P.
name: Karahalios, Karrie
Publisher: name: arXiv
Year: 2017
Subjects: subject: Social and Information Networks (cs.SI)
subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Search systems in online social media sites are frequently used to find information about ongoing events and people. For topics with multiple competing perspectives, such as political events or political candidates, bias in the top ranked results significantly shapes public opinion. However, bias does not emerge from an algorithm alone. It is important to distinguish between the bias that arises from the data that serves as the input to the ranking system and the bias that arises from the ranking system itself. In this paper, we propose a framework to quantify these distinct biases and apply this framework to politics-related queries on Twitter. We found that both the input data and the ranking system contribute significantly to produce varying amounts of bias in the search results and in different ways. We discuss the consequences of these biases and possible mechanisms to signal this bias in social media search systems' interfaces.
description: In Proceedings of ACM Conference on Computer Supported Cooperative Work & Social Computing (CSCW), Portland, USA, February 2017
Flexible Nanocellulose - Nanoparticle Composites: Structures and Properties
Creators: name: UTHPALA MANAVI GARUSINGHE
Publisher: name: Monash University
Year: 2018
Subjects: subject: 91202 Composite and Hybrid Materials
subject: FOS: Materials engineering

description: Nanocellulose is biodegradable and renewable and has many attractive properties of technological interest. Therefore, nanocellulose can be converted into thin films, which is used in wide range of applications. However, the property range achievable with nanocellulose by itself still has limitations. This thesis focuses on the production of nanocellulose-inorganic nanoparticle composites to combine the advantage associated with both individual components together to extend the range of properties achievable. In the first part, methods are developed to overcome the problems in composite production, characterization and optimization. Then the thesis focuses on engineering composites that can be used for high end applications.
New types of two component NLS-type equations
Creators: name: Gerdjikov, Vladimir S.
name: Stefanov, Alexander A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: 35Q15, 31A25, 37K10, 35Q58

description: We study MNLS related to the D.III-type symmetric spaces. Applying to them Mikhailov reduction groups of the type $\mathbb{Z}_r\times \mathbb{Z}_2$ we derive new types of 2-component NLS equations. These are {\bf not} counterexamples to the Zakharov-Schulman theorem because the corresponding interaction Hamiltonians depend not only on $|q_k|^2$, but also on $q_1q_2^* +q_1^* q_2$.
description: 14 pages
Additional file 1 of The People’s Trial: supporting the public’s understanding of randomised trials
Creators: name: Finucane, Elaine
name: O’Brien, Ann
name: Treweek, Shaun
name: Newell, John
name: Das, Kishor
name: Chapman, Sarah
name: Wicks, Paul
name: Galvin, Sandra
name: Healy, Patricia
name: Biesty, Linda
name: Gillies, Katie
name: Noel-Storr, Anna
name: Gardner, Heidi
name: O’Reilly, Mary Frances
name: Devane, Declan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Additional file 9: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Risk of Bias ≤6; Current Metformin Use Vs. No Current Metformin Use in Asian-Based Cohort Studies. Comparison of metformin use in Asian-based cohort studies with a Newcastle-Ottawa score ≤ 6. (DOCX 18 kb)
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Cart. 168 (11 H 66), f. 0147r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0147r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0147r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
On the normal modes of weak colloidal gels
Creators: name: Varga, Zsigmond
name: Swan, James W.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The normal modes and relaxation rates of weak colloidal gels are investigated in computations employing different models of the hydrodynamic interactions between colloids. The eigenspectrum is computed for freely draining, Rotne-Prager-Yamakawa and Accelerated Stokesian Dynamics approximations of the hydrodynamic mobility in a normal mode analysis of a harmonic network representing the gel. The spatial structure of the normal modes suggests that measures of collectivity and energy dissipation in the gels are fundamentally altered by long-ranged hydrodynamic interactions, while hydrodynamic lubrication affects only the relaxation rates of short wavelength modes. Models accounting for long-ranged hydrodynamic interactions exhibit a microscopic relaxation rate for each normal mode, $λ$ that scales as $λ\sim l^{-2}$, where $l$ is the spatial correlation length of the mode. For the freely draining approximation, $λ\sim l^γ$, where $γ$ varies between 3 and 2 with increasing $ϕ$. A simple phenomenological model of the internal elastic response to normal mode fluctuations is developed, which shows that long-ranged hydrodynamic interactions play a central role in the viscoelasticity of the gel network. Dynamic simulations show that the stress decay as measured by the time-dependent shear modulus matches the normal mode predictions and the phenomenological model. Analogous to the Zimm model in polymer physics, our results indicate that long-ranged hydrodynamic interactions play a crucial role in determining the microscopic dynamics and macroscopic properties of weak colloidal gels.
Fast Hybrid Image Retargeting
Creators: name: Valdez-Balderas, Daniel
name: Muraveynyk, Oleg
name: Smith, Timothy
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.10; I.4.0; I.5.4

description: Image retargeting changes the aspect ratio of images while aiming to preserve content and minimise noticeable distortion. Fast and high-quality methods are particularly relevant at present, due to the large variety of image and display aspect ratios. We propose a retargeting method that quantifies and limits warping distortions with the use of content-aware cropping. The pipeline of the proposed approach consists of the following steps. First, an importance map of a source image is generated using deep semantic segmentation and saliency detection models. Then, a preliminary warping mesh is computed using axis aligned deformations, enhanced with the use of a distortion measure to ensure low warping deformations. Finally, the retargeted image is produced using a content-aware cropping algorithm. In order to evaluate our method, we perform a user study based on the RetargetMe benchmark. Experimental analyses show that our method outperforms recent approaches, while running in a fraction of their execution time.
description: 5 pages
Cherlin's conjecture for almost simple groups of Lie rank 1
Creators: name: Gill, Nick
name: Hunt, Francis
name: Spiga, Pablo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20B15, 20D06, 03C13

description: We prove Cherlin's conjecture, concerning binary primitive permutation groups, for those groups with socle isomorphic to $\mathrm{PSL}_2(q)$, ${^2\mathrm{B}_2}(q)$, ${^2\mathrm{G}_2}(q)$ or $\mathrm{PSU}_3(q)$. Our method uses the notion of a "strongly non-binary action".
description: 14 pages
Process for thin film deposition through controlled formation of vapor phase transient species US Pat. 11,248,291
Creators: name: Arkles, Barry C.
name: Kaloyeros, Alain E.
Publisher: name: Zenodo
Year: 2022
Subjects: Epitaxy
Chemical Vapor Deposition (CVD)
Perhydridosilane
Cobalt
Thin Films
Silicon Chemistry

description: A method for deposition of a thin film onto a substrate is provided. The method includes providing a source precursor containing on or more of elements constituting the thin film, generating a transient species from the source precursor, and depositing a thin film onto the substrate from the transient species. The transient species being a reactive intermediate that has a limited lifetime in a condensed phase at or above room temperature.
Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study
Creators: name: Yu, Nianzhou
name: Wu, Lisha
name: Su, Juan
name: Chen, Mingliang
name: Lu, Lixia
name: Huang, Kai
name: Li, Yixin
name: Jiang, Zixi
name: Liu, Siliang
name: Peng, Lanyuan
name: Xie, Yang
name: Chen, Zeyu
name: Zhou, Wenhu
name: Wan, Miaojian
name: Fang, Fang
name: Bu, WenBo
name: Zhao, Shuang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Mohs micrographic surgery (MMS) is the preferable surgery for difficult -to-treat basal cell carcinoma (BCC) but is an expensive, labor-intensive, and time-consuming technique. The aim of this study is to compare the efficacy and safety of photodynamic therapy combined with surgery(S-PDT) versus Mohs micrographic surgery (MMS) for the treatment of difficult-to-treat BCC. This was a retrospective, comparative study. A total of 32 patients, 16 patients with 48 lesions, were treated with S-PDT, and the other 16 patients with 17 lesions treated by MMS were enrolled in this study. Follow-up was at least 36 months posttreatment. The recurrence rate was no statistical difference between the S-PDT and MMS (p = 1.000, Fishers exact test). The median follow-up was 42.5 months (range 36–63 months). The mean healing time in the S-PDT [17.9 d (SD 9.8)] is longer than in MMS [7.5 d (SD 1.5)] during follow-up (p＜.001, Independent T-test). On the whole, the cosmetic outcome of patients in S-PDT was statistically no significant difference with that in MMS according to a 4-point scale (p = .719, chi-squared test). S-PDT is a safe, effective, and novel cosmetic treatment, which holds the potential to be an alternative treatment to MMS for some cases.
Additional file 8: of Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis
Creators: name: Chen, Christopher
name: Eskin, Maxim
name: Eurich, Dean
name: Majumdar, Sumit
name: Johnson, Jeffrey
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Risk of Bias ≤6; Current Metformin Use Vs. No Current Metformin Use in Western-Based Cohort Studies. Comparison of metformin use in Western-based cohort studies with a Newcastle-Ottawa score ≤ 6. (DOCX 20 kb)
Bright end of the luminosity function of high-mass X-ray binaries: contributions of hard, soft and supersoft sources
Creators: name: Sazonov, Sergey
name: Khabibullin, Ildar
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using a spectral analysis of bright Chandra X-ray sources located in 27 nearby galaxies and maps of star-formation rate (SFR) and ISM surface densities for these galaxies, we constructed the intrinsic X-ray luminosity function (XLF) of luminous high-mass X-ray binaries (HMXBs), taking into account absorption effects and the diversity of HMXB spectra. The XLF per unit SFR can be described by a power law dN/d log L=2.0(L/10^39 erg/s)^(-0.6) (M_Sun/yr)^(-1) from L=10^38 to 10^40.5 erg/s, where L is the unabsorbed luminosity at 0.25-8 keV. The intrinsic number of luminous HMXBs per unit SFR is a factor of ~2.3 larger than the observed number reported before. The intrinsic XLF is composed of hard, soft and supersoft sources (defined here as those with the 0.25-2 keV to 0.25-8 keV flux ratio of <0.6, 0.6-0.95 and >0.95, respectively) in ~2:1:1 proportion. We also constructed the intrinsic HMXB XLF in the soft X-ray band (0.25-2 keV). Here, the numbers of hard, soft and supersoft sources prove to be nearly equal. The cumulative present-day 0.25-2 keV emissivity of HMXBs with luminosities between 10^38 and 10^40.5 erg/s is ~5 10^39 erg/s (M_Sun/yr)^(-1), which may be relevant for studying the X-ray preheating of the early Universe.
description: 37 pages, 40 figures, accepted for publication in MNRAS
A theoretical and empirical exploration of the adoption of employee empowerment practices: evidence from multinational subsidiaries in China
Creators: name: Yin, Yishuai
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: For many years, employee empowerment practices have been of major interest to both management scholars and practitioners. A large body of literature suggests that employee empowerment practices positively relate to organizational performance. However, insufficient is known about the factors that determine the adoption of empowerment practices by firms. Furthermore, most of the research on employee empowerment practices has been conducted in Western countries. To better understand this phenomenon, this thesis investigates the antecedents and outcomes of employee empowerment practices in MNE subsidiaries operating in China. Data were collected from MNE subsidiaries operating in China and analyses were based on three conceptual models. Drawing on transaction cost economics (TCE), the first model proposed that two employee - employer exchange characteristics, performance ambiguity and human asset specificity, independently and inter actively determine the degree of empowerment practices adopted by firms. It further examined the interactive effect of the employee - employer exchange characteristics and empowerment practices on organizational performance. Based on knowledge - based view (KB V) of the firm, the second model examined how employee empowerment practices influence knowledge transfer through individual level mechanisms with regard to employee perceived empowerment practices, psychological empowerment, knowledge sharing. Underpinned by institutional theory, the last model investigated how the informal institution and the subsidiaries' characteristics affect the degree of empowerment practices adopted in the MNE subsidiaries in China. Results revealed that all the three models were at least partially supported, suggesting each of the three models provided valuable insights to explain the adoption of employee empowerment practices. Overall, this thesis contributes to employee empowerment practices literature by shedding light on the underlying factors that influence the adoption of different degree of empowerment practices. This thesis goes beyond the current literature by initiating a new TCE perspective of employee empowerment practices and illuminating the economic nature of employee empowerment practices. It also extends our knowledge on the individual - level mechanism of how empowerment practices contribute to knowledge - based competitive advantage. Finally, it refines the understanding of contextual factors that specifically influenc e employ ee empowerment practices in MNE subsidiaries in China.
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0133
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0133, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0133, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Implementation of a quantum controlled-SWAP gate with photonic circuits
Creators: name: Ono, Takafumi
name: Okamoto, Ryo
name: Tanida, Masato
name: Hofmann, Holger F.
name: Takeuchi, Shigeki
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum information science addresses how the processing and transmission of information are affected by uniquely quantum mechanical phenomena. Combination of two-qubit gates has been used to realize quantum circuits, however, scalability is becoming a critical problem. The use of three-qubit gates may simplify the structure of quantum circuits dramatically. Among them, the controlled-SWAP (Fredkin) gates are essential since they can be directly applied to important protocols, e.g., error correction, fingerprinting, and optimal cloning. Here we report a realization of the Fredkin gate for photonic qubits. We achieve a fidelity of 0.85 in the computational basis and an output state fidelity of 0.81 for a 3-photon Greenberger-Horne-Zeilinger state. The estimated process fidelity of 0.77 indicates that our Fredkin gate can be applied to various quantum tasks.
description: 9 pages, 4 figures, Sci. Rep. 7, 45353 (2017)