cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks
Creators: name: Schilling, Eva-Maria
name: Scherer, Myriam
name: Rothemund, Franziska
name: Stamminger, Thomas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Viral replication
subject: Immunoprecipitation
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: DNA replication
subject: Phosphorylation
subject: Viruses Reproduction
subject: Transfection
subject: Genomics
subject: Small interfering RNA
subject: DNA repair
subject: Replikation
subject: Phosphorylierung
subject: Transfektion
subject: Genomik
subject: DNS-Reparatur

description: Flap endonuclease 1 (FEN1) is a member of the family of structure-specific endonucleases implicated in regulation of DNA damage response and DNA replication. So far, knowledge on the role of FEN1 during viral infections is limited. Previous publications indicated that poxviruses encode a conserved protein that acts in a manner similar to FEN1 to stimulate homologous recombination, double-strand break (DSB) repair and full-size genome formation. Only recently, cellular FEN1 has been identified as a key component for hepatitis B virus cccDNA formation. Here, we report on a novel functional interaction between Flap endonuclease 1 (FEN1) and the human cytomegalovirus (HCMV) immediate early protein 1 (IE1). Our results provide evidence that IE1 manipulates FEN1 in an unprecedented manner: we observed that direct IE1 binding does not only enhance FEN1 protein stability but also phosphorylation at serine 187. This correlates with nucleolar exclusion of FEN1 stimulating its DSB-generating gap endonuclease activity. Depletion of FEN1 and inhibition of its enzymatic activity during HCMV infection significantly reduced nascent viral DNA synthesis demonstrating a supportive role for efficient HCMV DNA replication. Furthermore, our results indicate that FEN1 is required for the formation of DSBs during HCMV infection suggesting that IE1 acts as viral activator of FEN1 in order to re-initiate stalled replication forks. In summary, we propose a novel mechanism of viral FEN1 activation to overcome replication fork barriers at difficult-to-replicate sites in viral genomes
Howe duality and algebras of the Askey-Wilson type: an overview
Creators: name: Gaboriaud, Julien
name: Vinet, Luc
name: Vinet, Stéphane
Publisher: name: arXiv
Year: 2019
Subjects: subject: Representation Theory (math.RT)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 20C35, 81R50, 17B37, 22E70, 81R12

description: The Askey-Wilson algebra and its relatives such as the Racah and Bannai-Ito algebras were initially introduced in connection with the eponym orthogonal polynomials. They have since proved ubiquitous. In particular they admit presentations as commutants that are related through Howe duality. This paper surveys these results.
description: 8 pages, Proceedings for XI. International Symposium Quantum Theory and Symmetries, 1 - 5 July 2019, Montreal, Canada
Planar proton minibeam irradiation elicits spatially confined DNA damage in a human epidermis model
Creators: name: Scherthan, Harry
name: Wagner, Stephanie-Quinta
name: Grundhöfer, Jan
name: Matejka, Nicole
name: Müller, Jessica
name: Müller, Steffen
name: Rudigkeit, Sarah
name: Sammer, Matthias
name: Schoof, Sarah
name: Port, Matthias
name: Reindl, Judith
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: 53BP1
subject: γ-H2AX
subject: proton minibeam radiation therapy
subject: skin model
subject: DDC 610 / Medicine & health
subject: Neoplasms; Radiotherapy
subject: Proton therapy
subject: DNA damage
subject: DNA repair
subject: Cell death
subject: Epidermis
subject: Krebs
subject: Strahlentherapie
subject: Protonentherapie
subject: DNS-Schädigung
subject: DNS-Reparatur

description: Simple Summary Radiotherapy can lead to severe side effects involving the skin. Proton minibeam radiotherapy (pMBRT) can avoid such side effects by sparing healthy tissue between radiation beams. Here, we spatially mapped DNA damage in response to different widths of proton minibeams (66, 408 and 920 µm) at escalating times after pMBRT, and discovered that focused 66 µm pMBRT induced severe DNA damage at the dose peaks, while damage in the spared tissue was not apparent. Wider proton minibeams (408, 920 µm) damaged all cells. Seventy-two hours after irradiation, DNA damage was repaired, while apoptotic cell death (active caspase-3+) increased significantly 24 and 72 h after pMBRT. Hence, highly focused minibeam-irradiation spares healthy tissue from DNA damage and cell death, which may add to the tissue-sparing effect observed at the macro scale. Thus, highly focused pMBRT may be used in radiotherapy to reduce side effects to the skin. Abstract Purpose: High doses of ionizing radiation in radiotherapy can elicit undesirable side effects to the skin. Proton minibeam radiotherapy (pMBRT) may circumvent such limitations due to tissue-sparing effects observed at the macro scale. Here, we mapped DNA damage dynamics in a 3D tissue context at the sub-cellular level. Methods: Epidermis models were irradiated with planar proton minibeams of 66 µm, 408 µm and 920 µm widths and inter-beam-distances of 2.5 mm at an average dose of 2 Gy using the scanning-ion-microscope SNAKE in Garching, GER. γ-H2AX + 53BP1 and cleaved-caspase-3 immunostaining revealed dsDNA damage and cell death, respectively, in time courses from 0.5 to 72 h after irradiation. Results: Focused 66 µm pMBRT induced sharply localized severe DNA damage (pan-γ-H2AX) in cells at the dose peaks, while damage in the dose valleys was similar to sham control. pMBRT with 408 µm and 920 µm minibeams induced DSB foci in all cells. At 72 h after irradiation, DNA damage had reached sham levels, indicating successful DNA repair. Increased frequencies of active-caspase-3 and pan-γ-H2AX-positive cells revealed incipient cell death at late time points. Conclusions: The spatially confined distribution of DNA damage appears to underlie the tissue-sparing effect after focused pMBRT. Thus, pMBRT may be the method of choice in radiotherapy to reduce side effects to the skin.
Unramified Heisenberg group extensions of number fields
Creators: name: Bleher, Frauke
name: Chinburg, Ted
name: Gillibert, Jean
Publisher: name: arXiv
Year: 2019
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11R20 (Primary) 11G30, 14H30 (Secondary)

description: We construct étale generalized Heisenberg group covers of hyperelliptic curves over number fields. We use these to produce infinite families of quadratic extensions of cyclotomic fields that admit everywhere unramified generalized Heisenberg Galois extensions.
description: 11 pages; added Remark 3.4, extended Section 3.3, shortened Section 4.2 and added Section 4.3
Systemtheorie: Theorie linearer Regelsysteme
Creators: name: Rauh, Andreas
name: Hofer, Eberhard P.
name: Danzer, Michael A.
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Lineare Regelsysteme
subject: DDC 620 / Engineering & allied operations
subject: Control theory
subject: Lineares zeitinvariantes System
subject: Regelungssystem
subject: Systemtheorie

description: In dieser Vorlesung wird zunächst eine Einführung in die Zustandsraumbeschreibung linearer zeitinvarianter Systeme gegeben. Diese Darstellungsform erlaubt die Anwendung moderner und universellerer Regelungsverfahren. Daher werden Stabilität, Steuerbarkeit und Beobachtbarkeit als wichtige strukturelle Eigenschaften linearer Systeme vorgestellt und Kriterien zu deren Überprüfung angegeben. Nach der Vorstellung der allgemeinen Struktur linearer Zustandsregelungen werden die wichtigsten Verfahren zum Entwurf linearer Zustandsrückführungen hergeleitet und deren Anwendung an Beispielen erläutert. Im folgenden Teil der Vorlesung wird die Beobachtung von Zustandsgrößen behandelt. Ausgehend von der allgemeinen Beobachterstruktur werden Entwurfsverfahren vorgestellt und die Analogie zum Reglerentwurf aufgezeigt. Die Vorlesung schließt mit einem Kapitel zur regelungstechnischen Behandlung von Störgrößen.
Additional file 1 of Preoperative endothelial dysfunction for the prediction of acute kidney injury after cardiac surgery using cardiopulmonary bypass: a pilot study based on a second analysis of the MONS study
Creators: name: Abrard, Stanislas
name: Streichenberger, Antoine
name: Riou, Jérémie
name: Hersant, Jeanne
name: Rineau, Emmanuel
name: Jacquet-Lagrèze, Matthias
name: Fouquet, Olivier
name: Henni, Samir
name: Rimmelé, Thomas
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 1. Supplemental Figures.
Bipolar Bozukluğunun Bilişsel Davranışçı Terapi Yöntemi İle Tedavisinin İncelenmesi Üzerine Sistematik Bir Derleme
Creators: name: ÖZDEMİR, İlayda
name: KARAAZİZ, Meryem
Publisher: name: Zenodo
Year: 2024

description: Bu derleme çalışmasının amacı Bipolar Bozukluk (BB) yaşayan bireylerde Bilişsel Davranışçı Terapi (BDT) tedavi biçiminin kullanımını incelemektir. Yapılan bu çalışmada sistematik derleme çalışması kullanılmış olup saha çalışması ya da herhangi bir ölçek kullanılmamıştır. Google Akademik Veri Tabanında 2001-2023 yılları arasında sadece İngilizce dilinde yapılmış olan bağlantılı anahtar kelimelerle özet ya da bütün metnine ulaşılabilen randomize kontrollü çalışmalar değerlendirilmiştir. Bu derleme çalışması Şubat 2024 ve Mayıs 2024 olmak üzere iki aşamada gerçekleşmiştir. Yapılan literatür taraması sonucunda 7 çalışma ele alınmıştır. Yorumlanan 7 çalışma randomize kontrollü çalışmalardır. 7 çalışmanın sonucunda da BB hastalarında BDT tedavisinin pozitif yönde etki ettiği görülmüştür. Bu derlemenin bulgularında, bilişsel davranışçı terapinin iyileşmede hızlandırıcı rol oynadığı ve kısa bir zamanda sonuca ulaşmada etkili bir yöntem olduğu sonucuna ulaşılmıştır.
One-loop CHY-Integrand of Bi-adjoint Scalar Theory
Creators: name: Feng, Bo
name: Hu, Chang
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, the one-loop CHY-integrands of bi-adjoint scalar theory has been reinvestigated. Differing from previous constructions, we have explicitly removed contributions from tadpole and massless bubbles when taking the forward limit of corresponding tree-level amplitudes. The way to remove those singular contributions is to exploit the idea of 'picking poles', which is to multiply a special cross ratio factor with the role of isolating terms having a particular pole structure.
description: 29 pages, 8 figures
Transcription factor RBPJL is able to repress notch target gene expression but is non-responsive to notch activation
Creators: name: Pan, Leiling
name: Hoffmeister, Philipp
name: Turkiewicz, Aleksandra
name: Huynh, N. N. Duyen
name: Große-Berkenbusch, Andreas
name: Knippschild, Uwe
name: Gebhardt, J. Christof M.
name: Baumann, Bernd
name: Borggrefe, Tilman
name: Oswald, Franz
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Notch signaling
subject: RBPJL
subject: RBPJ
subject: transcriptional repression
subject: PDAC
subject: Ptf1a
subject: SHARP
subject: AML
subject: DDC 610 / Medicine & health
subject: Receptors, Notch
subject: Signal transduction
subject: Neoplasms; Metabolism
subject: Krebs
subject: Gen notch
subject: Genexpression
subject: Transkriptionsfaktor

description: Simple Summary The transcription factor RBPJ is an integral part of the Notch signaling cascade. RBPJ can function as a coactivator when Notch signaling is activated but acts as a repressor in the absence of a Notch stimulus. Here, we characterized the function of RBPJL, a pancreas-specific paralog of RBPJ. Upon depletion of RBPJ using CRISPR/Cas9, we observed specific upregulation of Notch target gene expression. Reconstitution with RBPJL can compensate for the lack of RBPJ function in the repression of Notch target genes but is not able to mediate the Notch-dependent activation of gene expression. On the molecular level, we identified a limited capacity of RBPJL to interact with activated Notch1–4. Abstract The Notch signaling pathway is an evolutionary conserved signal transduction cascade present in almost all tissues and is required for embryonic and postnatal development, as well as for stem cell maintenance, but it is also implicated in tumorigenesis including pancreatic cancer and leukemia. The transcription factor RBPJ forms a coactivator complex in the presence of a Notch signal, whereas it represses Notch target genes in the absence of a Notch stimulus. In the pancreas, a specific paralog of RBPJ, called RBPJL, is expressed and found as part of the heterotrimeric PTF1-complex. However, the function of RBPJL in Notch signaling remains elusive. Using molecular modeling, biochemical and functional assays, as well as single-molecule time-lapse imaging, we show that RBPJL and RBPJ, despite limited sequence homology, possess a high degree of structural similarity. RBPJL is specifically expressed in the exocrine pancreas, whereas it is mostly undetectable in pancreatic tumour cell lines. Importantly, RBPJL is not able to interact with Notch−1 to −4 and it does not support Notch-mediated transactivation. However, RBPJL can bind to canonical RBPJ DNA elements and shows migration dynamics comparable to that of RBPJ in the nuclei of living cells. Importantly, RBPJL is able to interact with SHARP/SPEN, the central corepressor of the Notch pathway. In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. Together, RBPJL can act as an antagonist of RBPJ, which renders cells unresponsive to the activation of Notch.
title: Epigenetik: Der kleine Bruder der Genetik
Creators: name: Neurobiologie, Zoologisches
name: Witt, Tobias
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2023
Subjects: subject: Stream
subject: TIDig
subject: Open Educational Resources (OERs)
subject: 57

description: Teach It Digital OER (TIDig)
title: Herkules oder Sisyphus? Vom Erbe des gesetzlichen Unrechts im post-autokratischen Polen
Creators: name: Sadurski, Wojciech
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
Mediator subunits MED16, MED14, and MED2 are required for activation of ABRE-dependent transcription in arabidopsis
Creators: name: Lee, Morgan
name: Dominguez-Ferreras, Anna
name: Kaliyadasa, Ewon
name: Huang, Wei-Jie
name: Antony, Edna
name: Stevenson, Tracey
name: Lehmann, Silke
name: Schäfer, Patrick
name: Knight, Marc R.
name: Ntoukakis, Vardis
name: Knight, Heather
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: mediator complex
subject: ABA
subject: MED16
subject: MED14
subject: MED2
subject: ABRE
subject: DDC 570 / Life sciences
subject: Transcription
subject: Protoplasts
subject: Transkription
subject: Protoplast

description: The Mediator complex controls transcription of most eukaryotic genes with individual subunits required for the control of particular gene regulons in response to various perturbations. In this study, we reveal the roles of the plant Mediator subunits MED16, MED14, and MED2 in regulating transcription in response to the phytohormone abscisic acid (ABA) and we determine which cis elements are under their control. Using synthetic promoter reporters we established an effective system for testing relationships between subunits and specific cis-acting motifs in protoplasts. Our results demonstrate that MED16, MED14, and MED2 are required for the full transcriptional activation by ABA of promoters containing both the ABRE (ABA-responsive element) and DRE (drought-responsive element). Using synthetic promoter motif concatamers, we showed that ABA-responsive activation of the ABRE but not the DRE motif was dependent on these three Mediator subunits. Furthermore, the three subunits were required for the control of water loss from leaves but played no role in ABA-dependent growth inhibition, highlighting specificity in their functions. Our results identify new roles for three Mediator subunits, provide a direct demonstration of their function and highlight that our experimental approach can be utilized to identify the function of subunits of plant transcriptional regulators.
Novel Tests of the Key Innovation Hypothesis: Adhesive Toepads in Arboreal Lizards
Creators: name: Miller, Aryeh H
name: Stroud, James T
Publisher: name: Zenodo
Year: 2021
Subjects: lizards
Squamata
key innovations
macroevolutionary dynamics
Key innovation
Ecological Transition
phylogenetic comparative methods
Reptiles

description: Abstract The evolution of key innovations—unique features that enable a lineage to interact with the environment in a novel way—may drive broad patterns of adaptive diversity. However, traditional tests of the key innovation hypothesis, those which attempt to identify the evolutionary effect of a purported key innovation by comparing patterns of diversity between lineages with and without the key trait, have been challenged on both conceptual and statistical grounds. Here, we explore alternative, untested hypotheses of the key innovation framework. In lizards, adhesive toepad structures increase grip strength on vertical and smooth surfaces such as tree trunks and leaves and have independently evolved multiple times. As such, toepads have been posited as a key innovation for the evolution of arboreality. Leveraging a habitat use dataset applied to a global phylogeny of 2692 lizard species, we estimated multiple origins of toepads in three major clades and more than 100 origins of arboreality widely across the phylogeny. Our results suggest that toepads arise adaptively in arboreal lineages and are subsequently rarely lost while maintaining arboreal ecologies. Padless lineages transition away from arboreality at a higher rate than those with toepads, and high rates of invasion of arboreal niches by non-arboreal padbearing lineages provides further evidence that toepads may be a key to unlocking evolutionary access to the arboreal zone. Our results and analytical framework provide novel insights to understand and evaluate the ecological and evolutionary consequences of key innovations.
Eine qualitative Untersuchung zur Produktlinien-Integration über Organisationsgrenzen hinweg
Creators: name: Kohlmeyer, Jens
name: Raschke, Alexander
name: Tavakoli Kolagari, Ramin
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Embedded computer systems
subject: Software engineering
subject: Eingebettetes System
subject: Produktlinie
subject: Software

description: Software-Produktlinien für eingebettete Systeme spielen eine immer wichtigere Rolle in der Industrie. Hersteller mobiler Telefone und System-Zulieferer automobiler Steuergeräte, um nur zwei Beispiele zu nennen, verwenden schon heute Software-Produktlinien als mächtige Werkzeuge, um die Qualität ihrer Prozesse und Produkte zu verbessern: Die Wiederverwendung so genannter Kernelemente wird unterstützt, womit die Entwicklungszeit verkürzt wird und die Kosten verringert werden. Die Herausforderung, der sich die Hersteller von Kraftfahrzeugen nun gegenübersehen, ist es, ihre Wiederverwendungsansätze mit den häufig bei den Zulieferern vorliegenden Produktlinien zu koppeln. Da die Automobilhersteller ihre Systeme zumeist auf der Ebene von Anforderungen spezifizieren und dabei keine abgestimmte (Werkzeug-unterstützte) Schnittstelle zu ihren Lieferanten unterhalten, um die Anforderungsspezifikationen den Hardware- und Software-Lieferanten zur Implementierung zu übergeben, kommt es zu einem Bruch in der Systematik - die Lieferanten müssen die erhaltenen Spezifikationen regelmäßig neu in ihren Produktlinien-Ansatz einbetten, was zu höheren Kosten sowie Qualitätseinbußen führt. Wir untersuchten, inwieweit die Anwendung einer Produktlinie auf Seiten eines Automobilherstellers angepasst und mit der Wiederverwendungssystematik eines Lieferanten gekoppelt werden kann, so dass beide Seiten davon profitieren.
Additional file 2 of Preoperative endothelial dysfunction for the prediction of acute kidney injury after cardiac surgery using cardiopulmonary bypass: a pilot study based on a second analysis of the MONS study
Creators: name: Abrard, Stanislas
name: Streichenberger, Antoine
name: Riou, Jérémie
name: Hersant, Jeanne
name: Rineau, Emmanuel
name: Jacquet-Lagrèze, Matthias
name: Fouquet, Olivier
name: Henni, Samir
name: Rimmelé, Thomas
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy

description: Additional file 2: Table 1. Patient characteristics and outcomes according to the acute kidney injury stage, Table 2. Microcirculatory assessment results according to the acute kidney injury stage, Table 3. Stepwise model for LTH as predictor of postoperative acute kidney injury, Table 4. Stepwise model for peak amplitude during iontophoresis of ACh as predictor of postoperative acute kidney injury stage 3, Table 5. Stepwise model for Time to reach the peak after LTH as predictor of postoperative acute kidney injury stage 2-3.
Determinantal point processes and fermion quasifree states
Creators: name: Olshanski, Grigori
Publisher: name: arXiv
Year: 2020
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: Determinantal point processes are characterized by a special structural property of the correlation functions: they are given by minors of a correlation kernel. However, unlike the correlation functions themselves, this kernel is not defined intrinsically, and the same determinantal process can be generated by many different kernels. The non-uniqueness of a correlation kernel causes difficulties in studying determinantal processes. We propose a formalism which allows to find a distinguished correlation kernel under certain additional assumptions. The idea is to exploit a connection between determinantal processes and quasifree states on CAR, the algebra of canonical anticommutation relations. We prove that the formalism applies to discrete N-point orthogonal polynomial ensembles and to some of their large-N limits including the discrete sine process and the determinantal processes with the discrete Hermite, Laguerre, and Jacobi kernels investigated by Alexei Borodin and the author in [Commun. Math. Phys. 353 (2017), 853-903; arXiv:1608.01564]. As an application we resolve the equivalence/disjointness dichotomy for some of those processes.
description: to appear in Commun. Math. Phys.; v2: some typos fixed, uncited references removed
A combination of combat experience, early abduction, and severe traumatization fuels appetitive aggression and violence among abductees of rebel war in Northern Uganda
Creators: name: Zeller, Anja Carina
name: Conrad, Daniela
name: Schneider, Anna
name: Behnke, Alexander
name: Pfeiffer, Anett
name: Blum, Gerrit F.
name: Wilker, Sarah
name: Elbert, Thomas
name: Kolassa, Iris‐Tatjana
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: abduction
subject: appetitive aggression
subject: Lord's Resistance Army
subject: sensitive period
subject: traumatic load
subject: violence
subject: MALTREATMENT
subject: PSYCHOPATHY
subject: CONSEQUENCES
subject: CONFLICT
subject: SYMPTOMS
subject: SOLDIERS
subject: CHILDREN
subject: DDC 150 / Psychology
subject: DDC 570 / Life sciences
subject: Adverse childhood experiences
subject: Stress disorders, Traumatic
subject: Psychological trauma
subject: Child abuse
subject: Violence
subject: Psychisches Trauma
subject: Kind

description: Individuals who perpetrate violence may likely perceive violence as appealing and infliction of violence to derive pleasure is termed as appetitive aggression. Individuals who were abducted as children into an armed group often experience a higher number of traumatic event types, that is traumatic load and are usually socialized in a violence‐endorsing environment. This study aims to investigate the interaction between age at initial abduction with that of traumatic load, and their influence on appetitive aggression along with perpetration of violent acts by former members of an armed rebel group of both sexes. Semi‐structured interviews were conducted among a target group of formerly abducted rebel‐war survivors (including participants with and without combat experience) from Northern Uganda. Participants included 596 women and 570 men with N =  1,166 (Mage  =  32.58, SDage  =  9.76, range: 18–80 years). We conducted robust linear regression models to investigate the influence of age at initial abduction, traumatic load, combat experience, and biological sex on appetitive aggression as well as their perpetrated violent acts. Our study shows, appetitive aggression and the number of perpetrated violent acts were specifically increased in individuals who were abducted young, experienced several traumatic events in their lifetime, and with previous combat experience. For perpetrated violence men showed increased levels whereas for appetitive aggression the association was independent of biological sex. Therefore, early abducted individuals with a higher traumatic load, who have combat experience, need to be given special intervention to prevent any further violence.
Again on recognition and parsing of context free grammars: two exercises in transformational programming
Creators: name: Partsch, Helmut
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Context-free grammars
subject: Transformational programming
subject: DDC 004 / Data processing & computer science
subject: Parsing (Computer grammar)
subject: Parser
subject: Syntaktische Analyse

description: This paper deals with two aspects of transformational programming, viz. the formal derivation of logic programs from non-operational specifications and the construction of algorithms to solve problems formally specified by "inverse properties". Both aspects are illustrated by sarnple derivations of standard algorithms for recognition and parsing of context-free grammars.
Limitations of Greed: Influence Maximization in Undirected Networks Re-visited
Creators: name: Schoenebeck, Grant
name: Tao, Biaoshuai
name: Yu, Fang-Yi
Publisher: name: arXiv
Year: 2020
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Computational Complexity (cs.CC)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: We consider the influence maximization problem (selecting $k$ seeds in a network maximizing the expected total influence) on undirected graphs under the linear threshold model. On the one hand, we prove that the greedy algorithm always achieves a $(1 - (1 - 1/k)^k + Ω(1/k^3))$-approximation, showing that the greedy algorithm does slightly better on undirected graphs than the generic $(1- (1 - 1/k)^k)$ bound which also applies to directed graphs. On the other hand, we show that substantial improvement on this bound is impossible by presenting an example where the greedy algorithm can obtain at most a $(1- (1 - 1/k)^k + O(1/k^{0.2}))$ approximation. This result stands in contrast to the previous work on the independent cascade model. Like the linear threshold model, the greedy algorithm obtains a $(1-(1-1/k)^k)$-approximation on directed graphs in the independent cascade model. However, Khanna and Lucier showed that, in undirected graphs, the greedy algorithm performs substantially better: a $(1-(1-1/k)^k + c)$ approximation for constant $c > 0$. Our results show that, surprisingly, no such improvement occurs in the linear threshold model. Finally, we show that, under the linear threshold model, the approximation ratio $(1 - (1 - 1/k)^k)$ is tight if 1) the graph is directed or 2) the vertices are weighted. In other words, under either of these two settings, the greedy algorithm cannot achieve a $(1 - (1 - 1/k)^k + f(k))$-approximation for any positive function $f(k)$. The result in setting 2) is again in a sharp contrast to Khanna and Lucier's $(1 - (1 - 1/k)^k + c)$-approximation result for the independent cascade model, where the $(1 - (1 - 1/k)^k + c)$ approximation guarantee can be extended to the setting where vertices are weighted. We also discuss extensions to more generalized settings including those with edge-weighted graphs.
description: 36 pages, 1 figure, accepted at AAMAS'20: International Conference on Autonomous Agents and Multi-Agent Systems
title: "Un profeta e due angeli", copia da Allegri Antonio detto Correggio, inv. 113 (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Puddu, Pier Ludovico
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
A performance analysis model for a management architecture of multicore processing units
Creators: name: Bonfert, Stefan
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: MyThOS
subject: Performance Model
subject: Resource Management
subject: DDC 000 / Computer science, information & general works
subject: Performance Management
subject: Ressourcenmanagement

description: In the field of high performance computing the partitioning of a problem into smaller problems, that then are solved in parallel on multiple computing units, is a crucial task. In current software architectures the solving of those smaller problems on the operating system and application layer is carried out by threads, which have to be created and managed by the operating system. These tasks are computationally expensive. Because of the monolithic kernel of most modern operating systems, the tasks of managing and activating threads are sequentially performed by a central instance and are therefore hard to parallelize. For high performance systems, utilizing a large number of processing units, this centralized processing becomes a bottleneck. Operating system architectures, that are tailored for manycore processors, aim for parallelization and distribution of internal tasks of the kernel. This also applies to the management of threads, for which currently no universal model exists. Although a performance gain can be expected when using a distributed management of threads, additional tasks, like the synchronization of state or the delegation of tasks between the management instances, may impact the performance. In this thesis a generic model for a distributed thread management is developed. The influence of the number of thread management instances on the performance of applications is examined. This model offers a possibility to derive an optimal configuration of management instances in respect of distribution and communication overhead for a specific hardware configuration. This configuration significantly influences the latencies for creation of different amounts of threads, which should be minimized. The developed model is evaluated and validated by deriving a description for a specific hardware configuration. This description is then realized by an appropriate thread management facility which is implemented and integrated within a specialized OS.
sj-docx-1-eeg-10.1177_15500594221128713 - Supplemental material for Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment
Creators: name: Bayraktaroğlu, Zübeyir
name: Aktürk, Tuba
name: Yener, Görsev
name: de Graaf, Tom A.
name: Hanoğlu, Lütfü
name: Yıldırım, Ebru
name: Hünerli Gündüz, Duygu
name: Kıyı, İlayda
name: Sack, Alexander T.
name: Babiloni, Claudio
name: Güntekin, Bahar
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-1-eeg-10.1177_15500594221128713 for Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment by Zübeyir Bayraktaroğlu, Tuba Aktürk, Görsev Yener, Tom A. de Graaf, Lütfü Hanoğlu, Ebru Yıldırım, Duygu Hünerli Gündüz, İlayda Kıyı, Alexander T. Sack, Claudio Babiloni and Bahar Güntekin in Clinical EEG and Neuroscience
The dynamic nature of CO adlayers on Pt(111) electrodes
Creators: name: Wei, Jie
name: Amirbeigiarab, Reihaneh
name: Chen, Yan‐Xia
name: Sakong, Sung
name: Gross, Axel
name: Magnussen, Olaf
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: CO adlayer
subject: Density functional theory
subject: Pt(111)
subject: Surface mobility
subject: Single-crystal electrodes
subject: Surface-diffusion
subject: Elektrooxidation
subject: Mechanism
subject: DDC 540 / Chemistry & allied sciences
subject: Density functionals
subject: Scanning tunneling microscopy
subject: Carbon monoxide
subject: Oxidation
subject: Platinum
subject: Adsorption
subject: Electrocatalysis
subject: Rastertunnelmikroskopie
subject: Elektrokatalyse

description: CO adlayers on Pt(111) electrode surfaces are an important electrochemical system and of great relevance to electrocatalysis. The potential-dependent structure and dynamics of these adlayers are complex and still controversial, especially in the CO pre-oxidation regime. We here employ in situ high-speed scanning tunneling microscopy for studying the surface phase behavior in CO-saturated 0.1 m H2SO4 on the millisecond time scale. At potentials near the onset of CO pre-oxidation local fluctuations in the (2×2)-CO adlayer are observed, which increase towards more positive potentials. Above 0.20 V (vs. Ag/AgCl), this leads to an adlayer where COad apparently reside on every top site, but still exhibit a (2×2) superstructure modulation. We interpret this observation as a dynamic effect, caused by a small number of highly mobile point defects in the (2×2)-CO adlayer. As shown by density functional theory calculations, the CO lattice near such defects relaxes into a local (1×1) arrangement, which can rapidly propagate across the surface. This scenario, where a static (2×2) COad sublattice coexists with a highly dynamic sublattice of partially occupied top sites, explains the pronounced COad surface mobility during electrooxidation.
The impact of motivation and teachers’ autonomy support on children’s executive functions
Creators: name: Sosic-Vasic, Zrinka
name: Keis, Oliver
name: Lau, Maren
name: Spitzer, Manfred
name: Streb, Judith
Publisher: name: Universität Ulm
Year: 2015
Subjects: subject: autonomy
subject: self-regulation
subject: school
subject: DDC 150 / Psychology
subject: Executive functions (Neuropsychology)
subject: Motivation (Psychology)
subject: Independent study
subject: Self-culture
subject: Executive function
subject: Self-control
subject: Motivation
subject: Lernpsychologie
subject: Selbstgesteuertes Lernen
subject: Lernmotivation

description: The present study investigates the interplay of executive functions, motivation, and teacher’s autonomy support in school context. In a cross-sectional study design 208 students from different school types completed a standardized motivation questionnaire and processed two executive function tasks. All teachers who teach these students were asked about their autonomy supporting behavior by a standardized test. Multilevel analyses assessed the effects of the student’s motivation and their teachers’ autonomy support on student’s executive functions. Our results show considerable relationships between these variables: high executive function capacities came along with teacher’s autonomy support and student’s intrinsic motivation styles, whereas low executive function capacities were related to external regulation styles. The results indicate the importance of autonomy support in school instruction and disclose the need to popularize the self-regulation approach.
title: A key option to transfer geosciences – relate geoheritage to fun
Creators: name:  Frey ,   Marie-Luise
name:  Hogefeld ,   Christine
name:  Schmitz ,   Pascal
name:  Wolf ,   Klaudia
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Many attempts up to today exist to transfer geosciences to the general public. Some started at the beginning of the 20th century. It is surprising that only since the beginning of the 21st century with the formation of the European Geoparks Network in 2000 and the Global Geoparks Network in 2004, a new, consequent professional way of transfering geosciences was implemented. This includes information, education, geotourism, sustainable development of territories and at sites, e.g. Messel Pit World Heritage Site. These activities have opened people’s minds that landscapes are not „ugly, dirty and dead“. A starting signal was given to explain geoscientific phenomena with discovery activities, enthusiasm, passion and fun for children as well as for adults. Holistic views were initiated and not only fossil or mineral collections presented. By marketing beautiful landscapes, aesthetics of volcanos or reef limestone areas with caves, the interest of large amounts of visitors was raised. A key option however, found during about 18 years of geoscience knowledge transfer is to link up having fun within landscapes, with rocks, fossils and to enjoy a better understanding of where people live. Hands on activities have been reduced to zero during the pandemic of 2020. But why Earth is dynamic, changes landscapes and homes of people, this can be transmitted by edutainment games. An important aspect of this is geo-gamification: virtual and or by hands on, for „Generation Z“, as a key to attract students and too make people aware about the exciting planet Earth we live on.
Additional file 5 of Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma
Creators: name: Kim, Jeongsoo
name: Kim, Tae-Jin
name: Chae, Sehyun
name: Ha, Hyojeong
name: Park, Yejin
name: Park, Sunghee
name: Yoon, Chul Joo
name: Lim, Seon Ah
name: Lee, Hyemin
name: Kim, Jiyoung
name: Kim, Jungwon
name: Im, Kyungtaek
name: Lee, Kyunghye
name: Kim, Jeongmin
name: Kim, Daham
name: Lee, Eunju
name: Shin, Min Hwa
name: Park, Serk In
name: Rhee, Inmoo
name: Jung, Keehoon
name: Lee, Jeewon
name: Lee, Keun Hwa
name: Hwang, Daehee
name: Lee, Kyung-Mi
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 5
Supplemental Material - The Cumulative Prevalence of Congregate Care Placement for U.S. Children by Race/Ethnicity, 2019
Creators: name: Covington, Clayton C.
name: Sernaker, Sarah
name: Wildeman, Christopher
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material for The Cumulative Prevalence of Congregate Care Placement for U.S. Children by Race/Ethnicity, 2019 by Clayton C. Covington, Sarah Sernaker and Christopher Wildeman in Child Maltreatment
Figure S1 - Supplemental material for Management of Alopecia Areata With Topical JAK Inhibitor Therapy: An Evidence-Based Review
Creators: name: Abduelmula, Abrahim
name: Mufti, Asfandyar
name: Mistry, Jenna
name: Sachdeva, Muskaan
name: Beecker, Jennifer
name: Prajapati, Vimal H.
name: Yeung, Jensen
Publisher: name: SAGE Journals
Year: 2022
Subjects: Medicine

description: Supplemental material, Figure S1, for Management of Alopecia Areata With Topical JAK Inhibitor Therapy: An Evidence-Based Review by Abrahim Abduelmula, Asfandyar Mufti, Jenna Mistry, Muskaan Sachdeva, Jennifer Beecker, Vimal H. Prajapati and Jensen Yeung in Journal of Cutaneous Medicine and Surgery
title: Massenmedien im Russischunterricht
Creators: name: Klemmer, Astrid
Year: 2009

description: Nach dem heutigen Verständnis von Medienpädagogik, sollen SchülerInnen den kompetenten Umgang mit Medien erlernen, diese aktiv und passiv nutzen können, sich dabei aber auch über Probleme bewusst werden, die Medien mit sich bringen. Diese Arbeit zeigt unter Berücksichtigung medienpädagogischer und mediendidaktischer Grundsätze auf, wie man Massenmedien im Russischunterricht einsetzen kann, um dieses Bildungsziel des kritischen und verantwortungsbewussten Umgangs mit Medien erreichen zu können. Die Arbeit behandelt nicht alle Medien, dies wäre zu umfassend. Im Speziellen sollen Massenmedien thematisiert werden, und hier in erster Linie Internet, Presse und Film, Zeitung und Werbung. Ziel ist es, Methoden, Unterrichtsideen etc. zu beschreiben, mit Hilfe derer man Jugendliche im Rahmen des Russischunterrichts zu einer kritischen Mediennutzung anregen kann.
description: Today's understanding of media educational theory, pupils should learn how to use media actively and passively in a competent way. They should be aware of problems and threats which bring media with themselves. This work indicates taking into account media-educational and media-didactic principles as one can use mass media in the Russian lessons to be able to reach this educational aim of the critical and responsible contact with media. The work treats not all media, this would be too comprehensive. In the special mass media should be picked out as a central theme, and here, primarily, Internet, press and film, newspaper and advertisement. Aim is to describe methods, teaching ideas etc. with the help of which one can stimulate youngsters within the scope of the Russian lessons to a critical media use.
Supplemental Material - A Single-Centre Retrospective Analysis of Radial Versus Femoral Prostate Artery Embolization
Creators: name: Zakeri, Simon Arian
name: Mohammad, Fahad
name: Nowakowska, Magdalena
name: Kakani EBIR, Nirmal
name: Ananthakrishnan, Ganapathy
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Cardiology
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental Material for A Single-Centre Retrospective Analysis of Radial Versus Femoral Prostate Artery Embolization by Simon Arian Zakeri, Fahad Mohammad, Magdalena Nowakowska, Nirmal Kakani EBIR, and Ganapathy Ananthakrishnan in Vascular and Endovascular Surgery
On hardware implementations of stepped-carrier OFDM radars
Creators: name: Schweizer, Benedikt
name: Schindler, Daniel
name: Knill, Christina
name: Hasch, Jürgen
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: PLL
subject: Frequency-agility
subject: Phase noise
subject: Stepped carrier
subject: Transient behavior
subject: DDC 620 / Engineering & allied operations
subject: Orthogonal frequency division multiplexing
subject: Radar
subject: Transients (Dynamics)
subject: OFDM
subject: Phasenregelkreis
subject: Radar
subject: Transienter Zustand

description: Orthogonal frequency-division multiplexing (OFDM) is a promising candidate for future digital-centric radar systems. One major limitation for practical implementations is the required sampling rate in the order of GHz, which can be solved by using a stepped-carrier technique in combination with OFDM signals of smaller bandwidth, theoretically resulting in the same resolution as a conventional OFDM scheme. However, a signal source capable of generating such a carrier has to fulfill several constraints. In this paper, the effects of deterministic and random inaccuracies of the carrier generation as well as effects of phase noise are described and evaluated. A transient model that describes the switching between carriers is given and all effects are verified using a radar demonstrator at 77 GHz.
On the classification of topological orders
Creators: name: Johnson-Freyd, Theo
Publisher: name: arXiv
Year: 2020
Subjects: subject: Category Theory (math.CT)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We axiomatize the extended operators in topological orders (possibly gravitationally anomalous, possibly with degenerate ground states) in terms of monoidal Karoubi-complete $n$-categories which are mildly dualizable and have trivial centre. Dualizability encodes the word "topological," and we take it as the definition of "(separable) multifusion $n$-category"; triviality of the centre implements the physical principle of "remote detectability." We show that such $n$-categorical algebras are Morita-invertible (in the appropriate higher Morita category), thereby identifying topological orders with anomalous fully-extended TQFTs. We identify centreless fusion $n$-categories (i.e. multifusion $n$-categories with indecomposable unit) with centreless braided fusion $(n{-}1)$-categories. We then discuss the classification in low spacetime dimension, proving in particular that all $(1{+}1)$- and $(3{+}1)$-dimensional topological orders, with arbitrary symmetry enhancement, are suitably-generalized topological sigma models. These mathematical results confirm and extend a series of conjectures and proposals by X.G. Wen et al.
description: 32 pages. Accepted version
Supplemental Material - Exploring Language-Majored Undergraduates’ Needs of Entrepreneurial Mindset Competencies for an Effective Workplace Preparation Course in Vietnam
Creators: name: Nguyen, Tram T. M.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental Material for Exploring Language-Majored Undergraduates’ Needs of Entrepreneurial Mindset Competencies for an Effective Workplace Preparation Course in Vietnam by Tram T. M. Nguyen in Entrepreneurship Education and Pedagogy
Additional file 2 of Risk factors of multidrug-resistant organisms neonatal sepsis in Surabaya tertiary referral hospital: a single-center study
Creators: name: Miranda, Stefani
name: Harahap, Aminuddin
name: Husada, Dominicus
name: Faramarisa, Fara Nayo
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 2