cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Localization and subdiffusive transport in quantum spin chains with dilute disorder
Creators: name: Thomson, S. J.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Many-body localization
subject: Phase diagrams
subject: Disordered systems
subject: Nonequilibrium systems
subject: Exact diagonalization
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: It is widely believed that many-body localization in one dimension is fragile and can be easily destroyed by thermal inclusions; however, there are still many open questions regarding the stability of the localized phase and under what conditions it breaks down. Here I construct models with dilute disorder, which interpolate between translationally invariant and fully random models, in order to study the breakdown of localization. This opens up the possibility to controllably increase the density of thermal regions and examine the breakdown of localization as this density is increased. At strong disorder, the numerical results are consistent with commonly used diagnostics for localization even when the concentration of thermalizing regions is high. At moderate disorder, I present evidence for slow dynamics and subdiffusive transport across a large region of the phase diagram, suggestive of a “bad metal” phase. This suggests that dilute disorder may be a useful effective model for studying Griffiths effects in many-body localization, and perhaps also in a wider class of disordered systems.
Disentangling modular Walker-Wang models via fermionic invertible boundaries
Creators: name: Bauer, Andreas
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Anyons
subject: Exotic phases of matter
subject: Fermions
subject: Topological insulators
subject: Topological materials
subject: Topological order
subject: Topological phases of matter
subject: Topological superconductors
subject: Vortices in superconductors
subject: 500 Naturwissenschaften und Mathematik::530 Physik::539 Moderne Physik

description: Walker-Wang models are fixed-point models of topological order in 3+1 dimensions constructed from a braided fusion category. For a modular input category M, the model itself is invertible and is believed to be in a trivial topological phase, whereas its standard boundary is supposed to represent a (2+1)-dimensional chiral phase. In this work we explicitly show triviality of the model by constructing an invertible domain wall to vacuum as well as a disentangling generalized local unitary circuit in the case where M is a Drinfeld center. Moreover, we show that if we allow for fermionic (auxiliary) degrees of freedom inside the disentangling domain wall or circuit, the model becomes trivial for a larger class of modular fusion categories, namely, those in the Witt classes generated by the Ising unitary modular tensor category. We also discuss general (noninvertible) boundaries of general Walker-Wang models and describe a simple axiomatization of extended topological quantum field theory in terms of tensors.
title: 01_0597
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Iron depletion in mineral dust grains from Saturn’s main rings
Creators: name: Linti, Simon
name: Postberg, Frank
name: Hsu, Hsiang-Wen
name: Hillier, Jon K.
name: Fischer, Christian
name: Trieloff, Mario
name: Schmidt, Jürgen
name: Kempf, Sascha
name: Srama, Ralf
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: data analysis
subject: planets
subject: satellites
subject: Saturn
subject: rings
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::551 Geologie, Hydrologie, Meteorologie

description: During the Grand Finale orbits, Cassini’s Cosmic Dust Analyzer (CDA) recorded in situ mass spectra of ice and mineral nanodust grains ejected from Saturn’s main rings falling into the planet’s atmosphere. We present a compositional analysis of the mineral dust fraction employing a spectral deconvolution method to determine the elemental composition of these grains. The results indicate a relatively homogenous composition of exclusively Mg-rich silicates, with Mg, Si, and Ca close to CI chondritic abundances but a significant depletion in Fe and only traces of organic material at best. The Fe depletion becomes even more pronounced when compared to Fe-rich interplanetary dust particles encountered by CDA in the Saturnian system, which are assumed to contaminate and darken the main rings over time. We discuss potential explanations for the depletion, from which we favour compositional alteration of the infalling dust grains by impact-triggered chemistry in combination with dynamical selection effects and instrumental bias as the most plausible ones. This might cause an accumulation of Fe in the main rings over time, most likely in the form of oxides.
title: The role of innate immune responses in oncolytic adenovirus therapy in ovarian cancer
Creators: name: Leung, Elaine Yee Ling
Publisher: name: University of Glasgow
Year: 2018
Subjects: subject: immunotherapy, ovarian cancer, neoplasm, oncolytic viruses, biomarker, tissue culture, chemokines, IL-17, natural killer cells.

description: Epithelial ovarian cancer is the deadliest gynaecological cancer: most women die within five years of their diagnoses. Moreover, survival of women with ovarian cancer (OC) has not significantly improved in the past decade. Oncolytic viruses (OVs), a new class of anti-cancer agent, infect and replicate selectively within malignant cells, whilst sparing normal cells. OVs also induce profound immune responses, for example disruption of chemokine and cytokine networks, with potential influence on therapeutic effectiveness. On the other hand, Natural Killer cells (NK cells), a key immune population that surveillance against cancers and viruses, may hinder the spread of OVs or promote anti-tumoural effects of OVs. This work investigated the role of innate immune responses, in particular NK cells and interleukin (IL)-17F, on the efficacy of oncolytic adenovirus in OC. I demonstrated that NK cells were activated by adenovirus-infected OC cells. Activated NK cells then augmented oncolytic adenovirus in eliminating OC via contact-dependent interactions between activating NK receptor DNAM-1 and adenovirus-infected malignant cells. In addition, consistent changes in chemokines and cytokines were observed after wild-type and oncolytic adenovirus infection. In particular, IL-17F, but not IL-17A, was significantly upregulated in different established and primary OC lines after adenovirus infections. Moreover, a range of inflammatory chemokines, including CCL2, CXCL1, CXCL2 and CXCL5, were down-regulated after oncolytic adenovirus infection. This work also revealed the logistical and technical challenges of the use of primary patient materials. I identified that our primary culture method for expanding OC cells was suboptimal. I subsequently evaluated a simple immunohistochemical method to screen for successful primary expansion of malignant cells from OC ascites. I showed that PAX8, but not CK7, was a specific marker of successful ex vivo expansion of HGSOC.
HIM: DISCOVERING IMPLICIT RELATIONSHIPS IN HETEROGENEOUS SOCIAL NETWORKS
Creators: Bo Xu
Jinpeng Wang
Zhehuan Zhao
Hongfei Lin
Feng Xia
Publisher: name: IEEE Signal Processing Society
Year: 2024

description: To date, research on relation mining has typically focused on analyzing explicit relationships between entities, while ignoring the underlying connections between entities, known as implicit relationships. Exploring implicit relationships can reveal more about social dynamics and potential relationships in heterogeneous social networks to better explain complex social behaviors. The research presented in this paper explores implicit relationships discovery methods in the context of heterogeneous social networks. First, the creation of a novel implicit relationships dataset is described, namely HIMdata. Next, a framework for discovering implicit relationships in heterogeneous social networks is introduced. The proposed framework, HIM, innovatively integrates node attributes information and network structure information with graph convolutional networks for discovery of implicit relationships. Finally, HIM is evaluated on two different types of networks, achieving state-of-the-art performance on implicit relationship discovery tasks. The source codes are released at https://github.com/myjpgit/HIM.git.
MultiCellDS Version 1.0.0 XML Schemas (zip)
Creators: name: Friedman, Samuel
name: Macklin, Paul
Publisher: name: figshare
Year: 2016
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: These XML Schemas encode the MultiCellDS standard, Version 1.0.0.
Design criteria of cationic methacrylate polymers and their effect on transfection and cell toxicity
Creators: name: Salvado Correia, Joana
Publisher: name: Imperial College London
Year: 2022

description: Cationic polymers have been widely investigated as non-viral gene delivery solutions. The aim of this thesis was to identify key design criteria for the development of transfection agents for pancreatic cancer. A library of linear cationic copolymers was successfully synthesised using Group Transfer Polymerisation (GTP) and their physicochemical properties, cytotoxicity and ability to condense and deliver miRNA were systematically investigated. The 1st project of this thesis describes Polymer Series 1 and 2. In both series, polymer architecture was varied while MM and composition were kept constant. In Series 1, copolymers were synthesised with tri(ethylene gycol) ethyl ether methacrylate (TEGEMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). In Series 2, oligo(ethylene gycol) methyl methacrylate (OEGMA300) and DMAEMA were used. The aim of this 1st project was to investigate the effect monomer position (architecture) has in cytotoxicity, particularly, and subsequently in miRNA condensation ability and transfection efficiency. The 2nd project of this thesis describes Polymer Series 3, where 4 statistical copolymers of increasing MM were investigated for their properties, cytotoxic effects, miRNA antagonist condensation ability and transfection efficiency. The 3rd project of this thesis describes the functionalisation of statistical and diblock OEGMA-DMAEMA copolymers, of constant MM and composition, with a permanent charge (quaternisation, Series 4, Part I) and with cy5-azide, an imaging group (Series 5, Part II). The aims of this project were: (i) to understand if the addition of permanent positive charges would have detrimental effects on cytotoxicity, while improving polyplex formation and transfection efficiency; (ii) through the addition of an imaging group, understand if OEGMA-DMAEMA polymers are internalised by a range of cell lines and if monomer position would have an effect. In conclusion, it was identified that the position of the monomers in the polymer chain is a crucial feature in polymer design. The thermoresponsive properties of copolymers were affected by polymer architecture. It was also found that the random distribution of monomers along the polymer chain leads to more pronounced cell death than non-random (block) architectures. Such trend was also observed upon functionalisation of the copolymers with imaging groups or with permanent cationic charges.
MultiCellDS Version 1.0.0 Full Documentation
Creators: name: Friedman, Samuel
Publisher: name: figshare
Year: 2016
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: This is an auto-generated set of full documentation on MultiCellDS Version 1.0.0, created from the XML schema.
Animal social networks and female extra-pair paternity
Creators: name: Dunning, Jamie
Publisher: name: Imperial College London
Year: 2023

description: How animals choose to organise themselves socially has consequences for their subsequent survival and reproductive output, shaping evolutionary processes. However, the mechanisms by which such organisation influences their life history are complex and remain poorly understood; for example, the behaviour of reproductive partners, fine-scale social connections within non-reproductive groups, the broader social environment, and the physical environment all play a role in shaping the expression of social behaviours at the individual scale. In this thesis, which is separated into two parts, we consider the influence of social behaviour on reproductive choices. In the first part, we explore how researchers define a social association between individuals and then test the relationship between individual social behaviour and fitness at the annual and lifetime scales. In the second part, we apply concepts from animal social research to the question of female extra-pair paternity, which has long puzzled evolutionary ecologists. We conducted our research using a long-term study on wild house sparrows Passer domesticus, breeding on Lundy Island, and using a twenty-year genetic pedigree. We also used data from three other systems to compare the influence of association definition on social network structure. Our results suggest that individual sociality shapes reproductive choice in the short term, where the number of opposite-sex associates is correlated with reproductive success, but that social traits are likely to be subject to stabilising selection over a lifetime. Likewise, the inclusion of the social environment and social partner’s behavioural preference as an indirect genetic effect on female behaviour increased variance in quantitative genetics models for female extra-pair paternity, suggesting a role for social behaviour. Finally, we found a correlation between the female divorce rate (or propensity to switch social mates) and the solicitation of extra-pair males. Together, our results suggest that the social preference of individual animals, when appropriately defined, is a powerful force in the mediation of behavioural traits and subsequent fitness.
Supported MultiCellDS Cell Cycle Models
Creators: name: Macklin, Paul
name: Friedman, Samuel
name: Juarez, Edwin
Publisher: name: figshare
Year: 2016
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: This document describes the currently supported cell cycle models in MultiCellDS (multicellular data standard).
MultiCellDS User Overview
Creators: name: Friedman, Samuel
Publisher: name: figshare
Year: 2016
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: This is a hand-written (not auto-generated) overview of MultiCellDS: multicellular data standard. It gives a concise overview of all the major data elements, their relationships, and the rationale behind their design.
For more information, visit http://MultiCellDS.org
Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.
Creators: name: Nerlich, Jana
name: Kuenzel, Thomas
name: Keine, Christian
name: Korenic, Andrej
name: Rübsamen, Rudolf
name: Milenkovic, Ivan
Publisher: name: figshare
Year: 2017
Subjects: Neuroscience

description: Please find the peer-reviewed publisher version linked below.
GABA and glycine are the major inhibitory transmitters that attune neuronal activity in the CNS of mammals. The respective transmitters are mostly spatially separated, that is, synaptic inhibition in the forebrain areas is mediated by GABA, whereas glycine is predominantly used in the brainstem. Accordingly, inhibition in auditory brainstem circuits is largely mediated by glycine, but there are few auditory synapses using both transmitters in maturity. Little is known about physiological advantages of such a two-transmitter inhibitory mechanism. We explored the benefit of engaging both glycine and GABA with inhibition at the endbulb of Held-spherical bushy cell synapse in the auditory brainstem of juvenile Mongolian gerbils. This model synapse enables selective in vivo activation of excitatory and inhibitory neuronal inputs through systemic sound stimulation and precise analysis of the input (endbulb of Held) output (spherical bushy cell) function. The combination of in vivo and slice electrophysiology revealed that the dynamic AP inhibition in spherical bushy cells closely matches the inhibitory conductance profile determined by the glycine-R and GABAA-R. The slow and potent glycinergic component dominates the inhibitory conductance, thereby primarily accounting for its high-pass filter properties. GABAergic transmission enhances the inhibitory strength and shapes its duration in an activity-dependent manner, thus increasing the inhibitory potency to suppress the excitation through the endbulb of Held. Finally, in silico modeling provides a strong link between in vivo and slice data by simulating the interactions between the endbulb- and the synergistic glycine-GABA-conductances during in vivo-like spontaneous and sound evoked activities.
Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.
Creators: name: Nerlich, Jana
name: Kuenzel, Thomas
name: Keine, Christian
name: Korenic, Andrej
name: Rübsamen, Rudolf
name: Milenkovic, Ivan
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: Please find the peer-reviewed publisher version linked below.
GABA and glycine are the major inhibitory transmitters that attune neuronal activity in the CNS of mammals. The respective transmitters are mostly spatially separated, that is, synaptic inhibition in the forebrain areas is mediated by GABA, whereas glycine is predominantly used in the brainstem. Accordingly, inhibition in auditory brainstem circuits is largely mediated by glycine, but there are few auditory synapses using both transmitters in maturity. Little is known about physiological advantages of such a two-transmitter inhibitory mechanism. We explored the benefit of engaging both glycine and GABA with inhibition at the endbulb of Held-spherical bushy cell synapse in the auditory brainstem of juvenile Mongolian gerbils. This model synapse enables selective in vivo activation of excitatory and inhibitory neuronal inputs through systemic sound stimulation and precise analysis of the input (endbulb of Held) output (spherical bushy cell) function. The combination of in vivo and slice electrophysiology revealed that the dynamic AP inhibition in spherical bushy cells closely matches the inhibitory conductance profile determined by the glycine-R and GABAA-R. The slow and potent glycinergic component dominates the inhibitory conductance, thereby primarily accounting for its high-pass filter properties. GABAergic transmission enhances the inhibitory strength and shapes its duration in an activity-dependent manner, thus increasing the inhibitory potency to suppress the excitation through the endbulb of Held. Finally, in silico modeling provides a strong link between in vivo and slice data by simulating the interactions between the endbulb- and the synergistic glycine-GABA-conductances during in vivo-like spontaneous and sound evoked activities.
Inhibition shapes acoustic responsiveness in spherical bushy cells.
Creators: name: Keine, Christian
name: Rübsamen, Rudolf
Publisher: name: figshare
Year: 2017
Subjects: Neuroscience

description: Please find the peer-reviewed publisher version linked below.
Signal processing in the auditory brainstem is based on an interaction of neuronal excitation and inhibition. To date, we have incomplete knowledge of how the dynamic interplay of both contributes to the processing power and temporal characteristics of signal coding. The spherical bushy cells (SBCs) of the anteroventral cochlear nucleus (AVCN) receive their primary excitatory input through auditory nerve fibers via large, axosomatic synaptic terminals called the endbulbs of Held and by additional, acoustically driven inhibitory inputs. SBCs provide the input to downstream nuclei of the brainstem sound source localization circuitry, such as the medial and lateral superior olive, which rely on temporal precise inputs. In this study, we used juxtacellular recordings in anesthetized Mongolian gerbils to assess the effect of acoustically evoked inhibition on the SBCs input-output function and on temporal precision of SBC spiking. Acoustically evoked inhibition proved to be strong enough to suppress action potentials (APs) of SBCs in a stimulus-dependent manner. Inhibition shows slow onset and offset dynamics and increasing strength at higher sound intensities. In addition, inhibition decreases the rising slope of the EPSP and prolongs the EPSP-to-AP transition time. Both effects can be mimicked by iontophoretic application of glycine. Inhibition also improves phase locking of SBC APs to low-frequency tones by acting as a gain control to suppress poorly timed EPSPs from generating postsynaptic APs to maintain precise SBC spiking across sound intensities. The present data suggest that inhibition substantially contributes to the processing power of second-order neurons in the ascending auditory system.
title: Jungi Madamme
Creators: name: Hahn, Emilie
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022

description: TEI version for play in Alsatian. Play subtitle: Lustspiel in einem Aufzug in Strassburger Mundart
Slow Cholinergic Modulation of Spike Probability in Ultra-Fast Time-Coding Sensory Neurons
Creators: name: Goyer, David
name: Kurth, Stefanie
name: Gillet, Charlene
name: Keine, Christian
name: Rübsamen, Rudolf
name: Kuenzel, Thomas
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: Sensory processing in the lower auditory pathway is generally considered to be rigid and thus less subject to modulation than central processing. However, in addition to the powerful bottom-up excitation by auditory nerve fibers, the ventral cochlear nucleus also receives efferent cholinergic innervation from both auditory and nonauditorytop–down sources. We thus tested the influence of cholinergic modulation on highly precise time-coding neurons inthe cochlear nucleus of the Mongolian gerbil. By combining electrophysiological recordings with pharmacological application in vitro and in vivo, we found 55–72% of spherical bushy cells (SBCs) to be depolarized by carbachol on two time scales, ranging from hundreds of milliseconds to minutes. These effects were mediated by nicotinic and muscarinic acetylcholine receptors, respectively. Pharmacological block of muscarinic receptors hyperpolarized the resting membrane potential, suggesting a novel mechanism of setting the resting membrane potential for SBC. The cholinergic depolarization led to an increase of spike probability in SBCs without compromising the temporal precision of the SBC output in vitro. In vivo, iontophoretic application of carbachol resulted in an increase in spontaneous SBC activity. The inclusion of cholinergic modulation in an SBC model predicted an expansion of the dynamic range of sound responses and increased temporal acuity. Our results thus suggest of a top–down modulatory system mediated by acetylcholine which influences temporally precise information processing in the lower auditory pathway.
Inhibition shapes acoustic responsiveness in spherical bushy cells.
Creators: name: Keine, Christian
name: Rübsamen, Rudolf
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: Please find the peer-reviewed publisher version linked below.
Signal processing in the auditory brainstem is based on an interaction of neuronal excitation and inhibition. To date, we have incomplete knowledge of how the dynamic interplay of both contributes to the processing power and temporal characteristics of signal coding. The spherical bushy cells (SBCs) of the anteroventral cochlear nucleus (AVCN) receive their primary excitatory input through auditory nerve fibers via large, axosomatic synaptic terminals called the endbulbs of Held and by additional, acoustically driven inhibitory inputs. SBCs provide the input to downstream nuclei of the brainstem sound source localization circuitry, such as the medial and lateral superior olive, which rely on temporal precise inputs. In this study, we used juxtacellular recordings in anesthetized Mongolian gerbils to assess the effect of acoustically evoked inhibition on the SBCs input-output function and on temporal precision of SBC spiking. Acoustically evoked inhibition proved to be strong enough to suppress action potentials (APs) of SBCs in a stimulus-dependent manner. Inhibition shows slow onset and offset dynamics and increasing strength at higher sound intensities. In addition, inhibition decreases the rising slope of the EPSP and prolongs the EPSP-to-AP transition time. Both effects can be mimicked by iontophoretic application of glycine. Inhibition also improves phase locking of SBC APs to low-frequency tones by acting as a gain control to suppress poorly timed EPSPs from generating postsynaptic APs to maintain precise SBC spiking across sound intensities. The present data suggest that inhibition substantially contributes to the processing power of second-order neurons in the ascending auditory system.
Activity-dependent modulation of inhibitory synaptic kinetics in the cochlear nucleus
Creators: name: Nerlich, Jana
name: Keine, Christian
name: Rübsamen, Rudolf
name: R. Michael Burger
name: Milenkovic, Ivan
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: Spherical bushy cells (SBCs) in the anteroventral cochlear nucleus respond to acoustic stimulation with discharges that precisely encode the phase of low-frequency sound. The accuracy of spiking is crucial for sound localization and speech perception. Compared to the auditory nerve input, temporal precision of SBC spiking is improved through theengagement of acoustically evoked inhibition. Recently, the inhibition was shown to be less precise than previously understood. It shifts from predominantly glycinergic to synergistic GABA/glycine transmission in an activity-dependent manner. Concurrently, the inhibition attains a tonic character through temporal summation. The present study provides a comprehensive understanding of the mechanisms underlying this slow inhibitory input.We performed whole-cell voltage clamp recordings on SBCs from juvenile Mongolian gerbils and recorded evoked inhibitory postsynaptic currents (IPSCs) at physiological rates. The data reveal activity-dependent IPSC kinetics, i.e., the decay is slowed with increased input rates or recruitment. Lowering the release probability yielded faster decay kinetics of the single- and short train-IPSCs at 100 Hz, suggesting that transmitter quantity plays an important role in controlling the decay. Slow transmitter clearance from the synaptic cleft caused prolonged receptor binding and, in the case of glycine, spillover to nearby synapses. The GABAergic component prolonged the decay by contributing to the asynchronous vesicle release depending on the input rate. Hence, the different factors controlling the amount of transmitters in the synapse jointly slow the inhibition during physiologically relevant activity. Taken together, the slow time course is predominantly determined by the receptor kinetics and transmitter clearance during short stimuli, whereas long duration or high frequency stimulation additionally engage asynchronous release to prolong IPSCs.
[This Document is Protected by copyright and was first published by Frontiers. All rights reserved, it is reproduced with permission.]
Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments
Creators: name: Keine, Christian
name: Rübsamen, Rudolf
name: Englitz, Bernhard
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: Inhibition plays a crucial role in neural signal processing, shaping and limiting responses. In the auditory system, inhibition already modulates second order neurons in the cochlear nucleus, e.g. spherical bushy cells (SBCs). While the physiological basis of inhibition and excitation is well described, their functional interaction in signal processing remains elusive. Using a combination of in vivo loose-patch recordings, iontophoretic drug application, and detailed signal analysis in the Mongolian Gerbil, we demonstrate that inhibition is widely co-tuned with excitation, and leads only to minor sharpening of the spectral response properties. Combinations of complex stimuli and neuronal input-output analysis based on spectrotemporal receptive fields revealed inhibition to render the neuronal output temporally sparser and more reproducible than the input. Overall, inhibition plays a central role in improving temporal response fidelity of SBCs across a wide range of input intensities and thereby provides the basis for high-fidelity signal processing.
Revised 5/3/23 Variable/Measurement Section
Creators: name: Spitzer, Amanda N
name: Banister, Alyssa
name: Harmes, Cameron
name: Porter, Adam
name: Ahern, Riley
Publisher: name: OSF Registries
Year: 2023

description: We will measure the impact of helping behavior on self esteem with consideration for socio-economic status with an experiment that assigns participants to either a volunteer condition or a control condition. We will measure self-esteem with a sate self-esteem scale before and after the helping (or lack of helping) condition.
Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments
Creators: name: Keine, Christian
name: Rübsamen, Rudolf
name: Englitz, Bernhard
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: Inhibition plays a crucial role in neural signal processing, shaping and limiting responses. In the auditory system, inhibition already modulates second order neurons in the cochlear nucleus, e.g. spherical bushy cells (SBCs). While the physiological basis of inhibition and excitation is well described, their functional interaction in signal processing remains elusive. Using a combination of in vivo loose-patch recordings, iontophoretic drug application, and detailed signal analysis in the Mongolian Gerbil, we demonstrate that inhibition is widely co-tuned with excitation, and leads only to minor sharpening of the spectral response properties. Combinations of complex stimuli and neuronal input-output analysis based on spectrotemporal receptive fields revealed inhibition to render the neuronal output temporally sparser and more reproducible than the input. Overall, inhibition plays a central role in preserving or even improving temporal response fidelity of SBCs across a wide range of input intensities and thereby provides the basis for high-fidelity signal processing.
Hypertension and health related quality of life a comparative study.pdf
Creators: name: Rehman, Atiq Ur
Publisher: name: figshare
Year: 2016
Subjects: subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Objective: To examine the health related quality of life (HRQoL) among hypertensive persons versus normotensive persons and the effect of gender on health related quality of life among them. Methodology: A sample of 215 hypertensive persons, BP > 140/90 mm Hg with the age 45 ± 10 years (120 Male and 95 Female) and 215 normotensive persons, BP < 120/80 mm Hg with the age 45 ± 10 years (120 Male and 95 Female) were taken from the Tehsil Head Quarter Hospital (THQ) Jaranwala, Faisalabad by means of purposive sampling technique during the month of February and March 2016. For the measurement of health related quality of life, Health Related Quality of Life Inventory (HRQoL) SF-36 was utilized. Results: Poor HRQoL among hypertensive persons 65.91 ± 24.51 was observed as compared to normotensive persons 79.72 ±19.90. More poor HRQoL among female hypertensive 60.48 ±26.65 was observed as compared to male hypertensive 71.47 ± 22.36. Conclusion: Hypertension significantly adversely affects the health related quality of life of its victims and female are more at risk
title: 02_0590
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
The Relationship Between Breastfeeding, Sleep and Postpartum Depression.pdf
Creators: name: Rehman, Atiq Ur
Publisher: name: figshare
Year: 2016
Subjects: subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Objectives:(1)To assess the relationship between breastfeeding and postpartum depression. (2)To assessthe relationship between sleep and postpartum depression.Study Design: Cross sectional study.Place and duration of Study: The sample was drawn from Faisalabad, fromOctober4,2015 to December 22,2015.Methodology: A sample of 90 breastfeeding and 90 non-breastfeeding mothers were takenby purposivesampling technique. The sample inclusion criteria were, all participants were undergone vaginal delivery, sixweeks ago. Postpartum depression was measured by Edinburgh Postnatal Depression Scale (EPDS) andsleep was assessed by Pittsburgh Sleep Quality Index (PSQI).Results: In this study a significant association between breastfeeding, non- breastfeeding and postpartumdepression scores χ2 = 6.95, p < 0.05 was observed and similarly a significant association between sleepscores and postpartum depression scores χ 2 = 11.17, p < 0.05 was observed. Results reveal that there is asignificant relationship between breastfeeding, sleep and postpartum depression.Conclusion: Non- breastfeeding and poor sleep both are risk factors for postpartum depression.
Bio-Inspired Animated Characters A Mechanistic & Cognitive View
Creators: name: Simpson Bond
Publisher: name: figshare
Year: 2016
Subjects: subject: 90602 Control Systems, Robotics and Automation
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Unlike traditional animation techniques, which attempt
to copy human movement, ‘cognitive’ animation solutions mimic
the brain’s approach to problem solving, i.e., a logical (intelligent)
thinking structure. This procedural animation solution uses bioinspired insights (modelling nature and the workings of the brain)
to unveil a new generation of intelligent agents. As with any
promising new approach, it raises hopes and questions; an extremely
challenging task that offers a revolutionary solution, not just in
animation but to a variety of fields, from intelligent robotics and
physics to nanotechnology and electrical engineering. Questions,
such as, how does the brain coordinate muscle signals? How does
the brain know which body parts to move? With all these activities
happening in our brain, we examine how our brain ‘sees’ our body
and how it can affect our movements. Through this understanding
of the human brain and the cognitive process, models can be
created to mimic our abilities, such as, synthesizing actions that
solve and react to unforeseen problems in a humanistic manner.
We present an introduction to the concept of cognitive skills, as
an aid in finding and designing a viable solution. This helps us
address principal challenges, such as: How do characters perceive
the outside world (input) and how does this input influence their
motions? What is required to emulate adaptive learning skills as
seen in higher life-forms (e.g., a child’s cognitive learning process)?
How can we control and ‘direct’ these autonomous procedural
character motions? Finally, drawing from experimentation and
literature, we suggest hypotheses for solving these questions and
more. In summary, this article analyses the biological and cognitive
workings of the human mind, specifically motor skills. Reviewing
cognitive psychology research related to movement in an attempt
to produce more attentive behavioural characteristics. We conclude
with a discussion on the significance of cognitive methods for creating
virtual character animations, limitations and future applications.
D2.5-Profiling Analytics and Privacy Methodological Foundations, Release II
Creators: name: Suite5
name: Frankfurt University
name: UBITECH
name: NTUA
Publisher: name: Zenodo
Year: 2020
Subjects: analytics methodology
machine learning
profiling
GDPR
privacy
anonymization

description: After the first implementation iteration of ChildRescue and the initial pilot experiences, the methodologies, algorithms and approaches reported in D2.4 and stemming from D2.1, D2.2 and D2.3 will be updated. This deliverable will incorporate the initial input and the provided feedback/updates and will include the final incorporated methodology for Profiling, Analytics and Privacy.
NM 03 - Monitoramento e Avaliação de Programas de Governo – SICONP/MAP
Creators: name: Pereira, Olavo Gomes
name: Amoras, Roberto Paulo
name: Jesus, Adilson Vasconcellos
Publisher: name: Zenodo
Year: 2015
Subjects: Administração Pública (Brasil)
Governo do Estado do Pará (Brasil)
Auditoria Operacional
Diretrizes do CONACI

description: Subprocesso NM03 - Monitoramento e Avaliação de Programas de Governo – SICONP/MAP DESCRIÇÃO: O locus de atuação do SICONP/MAP reside no processo de monitoramento e avaliação das Políticas Públicas, no que concerne ao desempenho físico e financeiro da execução dos Programas de Governo, Ações, Projetos-Atividades. Através das informações mensais dos percentuais físico e financeiro realizados, dos seus respectivos valores anuais previstos, obtém-se um ponto para cada Ação, ProjetoAtividade. Este ponto sinaliza a velocidade de execução; com isto, de antemão, pode-se classificar o desempenho da Ação como Baixo, Médio ou Alto e alertar, com significativa antecedência, nos casos de baixo desempenho, para o risco da execução não alcançar as metas estabelecidas. O Sistema permite detectar as Ações que apresentam Economicidade (gastos envolvidos), Eficiência (Produtividade – mais com menos), Eficácia (Atingir os objetivos).
NM05 - Monitoramento de Dispensas e Inexigibilidades de Licitação – SICONP/MDI
Creators: name: Amoras, Roberto Paulo
name: Jesus, Adilson Vasconcellos
name: Mendes, Roberto Carlos Alves
Publisher: name: Zenodo
Year: 2015
Subjects: Administração Pública (Brasil)
Governo do Estado do Pará (Brasil)
Controle Interno
Licitação
Dispensa e Inexigibilidade

description: O subprocesso NM05: Monitoramento de Dispensas e Inexigibilidades de Licitação – SICONP/MDI DESCRIÇÃO: O SICONP/MDI permite detectar as contratações por Dispensa e Inexigibilidade de Licitação praticados pelos Órgãos/Entidades do Poder Público Estadual, proporcionando ações tempestiva de controle. É utilizado para comprovação da legalidade e observância dos demais princípios constitucionais nas Contratações Diretas de bens e serviços pelo Poder Executivo. Caso necessário, permite ainda ao Sistema de Controle Interno proceder preventivamente na solução de impropriedades eventualmente detectadas ou, quando não for possível saná-las, interromper o processo até que se recupere a sua regularidade ou mesmo determinar sua suspensão.
Biometric measurements for Black Skimmer (Rynchops niger) subspecies
Creators: name: Vieira, Bianca
Publisher: name: figshare
Year: 2016
Subjects: subject: Marine Biology
subject: 60308 Life Histories
subject: FOS: Biological sciences
subject: 60809 Vertebrate Biology
subject: Anatomy

description: This supplementary material contains a compilation of biometric measurements according to sex available in the literature for the Black Skimmer (Rynchops niger Linnaeus, 1758). It also contains the biometric measurements of specimens at the British Natural History Museum (BNHM) and at the Rio de Janeiro National Museum (MNRJ).
National Data Services Framework (NDSF) Summit 2020: Summary and Recommendations
Creators: name: Attendees Of The 2020 NDSF Summit
name: Leggott, Mark
name: Nicholson, Robyn
Publisher: name: Zenodo
Year: 2020
Subjects: subject: research data management
subject: National Data Services Framework
subject: NDSF
subject: digital research infrastructure
subject: https://codata.org/rdm-glossary/research-data-management/
subject: https://codata.org/rdm-glossary/data-management/
subject: https://codata.org/rdm-glossary/digital-infrastructure/

description: This document summarizes the input from attendees of the 2020 National Data Services Framework (NDSF) Summit, including outputs from three breakout discussion groups, a collaborative Notes document, and feedback on the Kanata Declaration (which emerged from the 2019 NDSF Summit). Some of the elements reflected here are also highlighted in the updated 2020 version of the Kanata Declaration. Participant feedback is summarized and categorized, highlighting emerging themes and overarching recommendations.
Myostain is involved in ginsenoside Rb1-mediated anti-obesity
Creators: name: Li, Hong-Shi
name: Kuang, Jiang-Ying
name: Liu, Gui-Jun
name: Wu, Wei-Jie
name: Yin, Xian-Lun
name: Li, Hao-Dong
name: Wang, Lei
name: Qin, Tao
name: Zhang, Wen-Cheng
name: Sun, Yuan-Yuan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Obesity, one of the major public health problems worldwide, has attracted increasing attention. Ginsenoside Rb1 is the most abundant active component of Panax ginseng C.A.Mey (Araliaceae) and is reported to have beneficial effects on obesity and diabetes. However, the mechanisms by which Rb1 regulates obesity remain to be explored. This paper intends to further explore the mechanism of Rb1 in regulating obesity. The C57BL/6 obese mice were divided into two groups: the control (CTR) and Rb1. The CTR group [intraperitoneally (ip) administered with saline] and the Rb1 group (ip administered with Rb1, 40 mg/kg/d) were treated daily for four weeks. In vitro, Rb1 (0, 10, 20, 40 μM) was added to differentiated C2C12 cells and Rb1 (0, 20, 40 μM) was added to 3T3-L1 cells. After 24 h, total RNA and protein from C2C12 cells and 3T3-L1 cells were used to detect myostatin (MSTN) and fibronectin type III domain-containing 5 (FNDC5) expression. Rb1 reduced the body weight and adipocyte size. Improved glucose tolerance and increased basic metabolic activity were also found in Rb1 treated mice. MSTN was downregulated in differentiated C2C12 cells, 3T3-L1 cells and adipose tissues upon Rb1 treatment. FNDC5 was increased after Rb1 treatment. However, MSTN overexpression attenuated Rb1-mediated decrease accumulation of lipid droplets in differentiated 3T3-L1 adipocytes. Rb1 may ameliorate obesity in part through the MSTN/FNDC5 signalling pathway. Our results showed that Rb1 can be used as an effective drug in the treatment of human obesity.
Figure S3 from The influence of wing morphology upon the dispersal, geographical distributions and diversification of the Corvides (Aves; Passeriformes)
Creators: name: Kennedy, Jonathan D.
name: Borregaard, Michael K.
name: Jønsson, Knud A.
name: Marki, Petter Z.
name: Fjeldså, Jon
name: Rahbek, Carsten
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: New species are sometimes known to arise as a consequence of the dispersal and establishment of populations in new areas. It has nevertheless been difficult to demonstrate an empirical link between rates of dispersal and diversification, partly because dispersal abilities are challenging to quantify. Here, using wing morphology as a proxy for dispersal ability, we assess this relationship among the global radiation of corvoid birds. We found that species distributions are associated with wing shape. Widespread species (occurring on both islands and continents), and those that are migratory, exhibit wing morphologies better adapted to long-distance flight compared with sedentary continental or insular forms. Habitat preferences also strongly predict wing form, with species that occur in canopies and/or areas of sparse vegetation possessing dispersive morphologies. By contrast, we found no significant differences in diversification rates among either the migratory or habitat classifications, but species distributed in island settings diversify at higher rates than those found on continents. This latter finding may reflect the elevated dispersal capabilities of widespread taxa, facilitating the radiation of these lineages across insular areas. However, as the correlations between wing morphology and diversification rates were consistently weak throughout our dataset, this suggests that historical patterns of diversification are not particularly well reflected by present-day wing morphology.