cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Rapid and annealing-free self-assembly of DNA building blocks for 3D hydrogel chaperoned by cationic comb-type copolymers
Creators: name: Zhang, Zheng
name: Wu, Yuyang
name: Yu, Feng
name: Niu, Chaoqun
name: Du, Zhi
name: Chen, Yong
name: Du, Jie
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: The construction and self-assembly of DNA building blocks are the foundation of bottom-up development of three-dimensional DNA nanostructures or hydrogels. However, most self-assembly from DNA components is impeded by the mishybridized intermediates or the thermodynamic instability. To enable rapid production of complicated DNA objects with high yields no need for annealing process, herein different DNA building blocks (Y-shaped, L- and L′-shaped units) were assembled in presence of a cationic comb-type copolymer, poly (L-lysine)-graft-dextran (PLL-g-Dex), under physiological conditions. The results demonstrated that PLL-g-Dex not only significantly promoted the self-assembly of DNA blocks with high efficiency, but also stabilized the assembled multi-level structures especially for promoting the complicated 3D DNA hydrogel formation. This study develops a novel strategy for rapid and high-yield production of DNA hydrogel even derived from instable building blocks at relatively low DNA concentrations, which would endow DNA nanotechnology for more practical applications. This work illustrates a cationic comb-type copolymer to promote the self-assembly of different DNA building units especially of complicated 3D DNA hydrogel with highly efficiency and stability.
Overview of BioASQ 2022: The tenth BioASQ challenge on Large-Scale Biomedical Semantic Indexing and Question Answering
Creators: name: Nentidis, Anastasios
name: Katsimpras, Georgios
name: Vandorou, Eirini
name: Krithara, Anastasia
name: Miranda-Escalada, Antonio
name: Gasco, Luis
name: Krallinger, Martin
name: Paliouras, Georgios
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: This paper presents an overview of the tenth edition of the BioASQ challenge in the context of the Conference and Labs of the Evaluation Forum (CLEF) 2022. BioASQ is an ongoing series of challenges that promotes advances in the domain of large-scale biomedical semantic indexing and question answering. In this edition, the challenge was composed of the three established tasks a, b, and Synergy, and a new task named DisTEMIST for automatic semantic annotation and grounding of diseases from clinical content in Spanish, a key concept for semantic indexing and search engines of literature and clinical records. This year, BioASQ received more than 170 distinct systems from 38 teams in total for the four different tasks of the challenge. As in previous years, the majority of the competing systems outperformed the strong baselines, indicating the continuous advancement of the state-of-the-art in this domain.
description: 25 pages, 14 tables, 4 figures. arXiv admin note: substantial text overlap with arXiv:2106.14885
Facile synthesis, characterization, and antimicrobial studies of some disubstituted 1,2,3-triazoles with sulfonamide functionality
Creators: name: P. Kaushik, C.
name: Pahwa, Ashima
name: Kumar, Ashwani
name: Singh, Dharmendra
name: Kumar, Krishan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: An expedient synthesis of some 1,4-disubstituted 1,2,3-triazoles (3a–3x) having sulfonamide functionality from various terminal alkynes and aromatic azides through Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition has been reported. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, high-resolution mass spectra and screened for in vitro antimicrobial activity against Staphylococcus aureus (Gram-positive bacteria), Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes (Gram-negative bacteria), Candida albicans, and Aspergillus niger (fungi). Some of the synthesized compounds were found to exhibit good potency against above-tested microbial strains. Moreover, to study the binding interactions, docking simulation of broadly active compound 3x was also performed against E. coli dihydropteroate synthase enzyme.
Addition of MRI for CT-based pancreatic tumor delineation: a feasibility study
Creators: name: Gurney-Champion, Oliver J.
name: Versteijne, Eva
name: Horst, Astrid Van Der
name: Lens, Eelco
name: Rütten, Heidi
name: Heerkens, Hanne D.
name: Paardekooper, Gabriel M. R. M.
name: Berbee, Maaike
name: Rasch, Coen R. N.
name: Stoker, Jaap
name: Engelbrecht, Marc R. W.
name: Herk, Marcel Van
name: Nederveen, Aart J.
name: Klaassen, Remy
name: Laarhoven, Hanneke W. M. Van
name: Geertjan Van Tienhoven
name: Bel, Arjan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Purpose: To assess the effect of additional magnetic resonance imaging (MRI) alongside the planning computed tomography (CT) scan on target volume delineation in pancreatic cancer patients. Material and methods: Eight observers (radiation oncologists) from six institutions delineated the gross tumor volume (GTV) on 3DCT, and internal GTV (iGTV) on 4DCT of four pancreatic cancer patients, while MRI was available in a second window (CT + MRI). Variations in volume, generalized conformity index (CIgen), and overall observer variation, expressed as standard deviation (SD) of the distances between delineated surfaces, were analyzed. CIgen is a measure of overlap of the delineated iGTVs (1 = full overlap, 0 = no overlap). Results were compared with those from an earlier study that assessed the interobserver variation by the same observers on the same patients on CT without MRI (CT-only). Results: The maximum ratios between delineated volumes within a patient were 6.1 and 22.4 for the GTV (3DCT) and iGTV (4DCT), respectively. The average (root-mean-square) overall observer variations were SD = 0.41 cm (GTV) and SD = 0.73 cm (iGTV). The mean CIgen was 0.36 for GTV and 0.37 for iGTV. When compared to the iGTV delineated on CT-only, the mean volumes of the iGTV on CT + MRI were significantly smaller (32%, Wilcoxon signed-rank, p Conclusions: The availability of MRI images during target delineation of pancreatic cancer on 3DCT and 4DCT resulted in smaller target volumes and reduced the interobserver variation in six out of eight delineated structures.
Facile Synthesis, Characterization and Antimicrobial Studies of Some Disubstituted 1,2,3-triazoles with Sulfonamide Functionality
Creators: name: P. Kaushik, C.
name: Pahwa, Ashima
name: Kumar, Ashwani
name: Singh, Dharmendra
name: Kumar, Krishan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: An expedient synthesis of some 1,4-disubstituted 1,2,3-triazoles (3a–3x) having sulfonamide functionality from various terminal alkynes and aromatic azides via Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition has been reported. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, HRMS and screened for in vitro antimicrobial activity against Staphylococcus aureus (Gram positive bacteria), Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes (Gram negative bacteria);Candida albicans andAspergillus niger(fungi). Some of the synthesized compounds were found to exhibit good potency against above tested microbial strains. Moreover, to study the binding interactions, docking simulation of broadly active compound 3x was also carried out againstE. coli dihydropteroate synthase enzyme.
Design, synthesis, crystal structure and insecticidal evaluation of novel arylpyrazole derivatives containing cyhalothroyl thiourea moiety
Creators: name: Han, Zhen-Yu
name: Wu, Wen-Yuan
name: Chen, Fu-Li
name: Guan, Xi-Lin
name: Fu, Xiao-Huan
name: Jiang, Peng
name: Wan, Rong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: On the basis of the commercial insecticide Fipronil, a series of novel arylpyrazole derivatives containing the cyhalothroyl thiourea moiety were designed and synthesized via the key intermediate 5-amino-3-cyano-1-(substituted phenyl) pyrazole. The structures of target compounds were characterized by 1H NMR, FT-IR, elemental analysis and single crystal X-ray diffraction analysis. Their insecticidal activities against Culex pipiens and Musca domestica were evaluated. The results of bioassays indicated that title compounds exhibited satisfactory insecticidal activities. Among those, Compound 7t ((E)-3-(2-chloro- 3, 3, 3-trifluoroprop-1-en-1-yl)-N-((3-cyano-1-(2, 6- dichloro-4-(trifluoromethyl) phenyl)-1H-pyrazol-5-yl) carbamothioyl)- 2, 2-dimethyl cyclopropane carboxamide) exhibited the best insecticidal activities because of its lowest KT50 values, which are superior to the commercial insecticide Dextral tetramethrin and similar to Prallethrin. The type and position of substituent on the benzene ring played important roles on the biological activities of target compounds.
Cocktail without hangover: in search for the optimal chemotherapy in the combined management of non-operable esophageal carcinomas
Creators: name: So, Bianca
name: Marcu, Loredana G.
name: Olver, Ian
name: Raghu Gowda
name: Bezak, Eva
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Background: The worldwide incidence of esophageal cancer has greatly increased over the past few decades making it the sixth deadliest cancer. The disease is often detected in advanced stages when surgery is no longer an option. The standard treatment in these situations is combined chemoradiotherapy, by employing drug cocktails that lead to optimal treatment outcomes both from the perspective of tumor control and normal tissue toxicity. Methods: The aim of this work was to collate the existing trials and clinical studies reported on non-operable esophageal cancer and to analyze the results based on treatment outcomes after various drug combinations. Results: Of all drug combinations, cisplatin/5-FU is the most well established chemotherapy regimen for esophageal cancer as both neoadjuvant therapy, an alternative option to surgery, and for palliative purposes. Although this regimen is associated with the most toxicity, it also appears to have the best survival benefit and relief of symptoms. Conclusions: More research is warranted to further increase the therapeutic ratio in non-operable esophageal cancers.
Stopping Rule
Creators: name: Abreu, Marcia
name: Rodrigues, Victória Do Monte
Publisher: name: OSF Registries
Year: 2024

description: Every morning, from Monday to Friday, a team of hospital professionals will inform us if there are children able to participate in the research. The group to which he/she will be assigned will be drawn. Once one group reaches 15 children of a given sex, that group will only be included in the draw if the available child is of the opposite sex. As soon as a group reaches 30 children, the group will be eliminated from the draw.
Sample Size
Creators: name: Abreu, Marcia
name: Rodrigues, Victória Do Monte
Publisher: name: OSF Registries
Year: 2024

description: The study will involve 60 hospitalized children (boys and girls) aged between 6 and 10 years, randomly split into 2 groups.
In addition to those groups, if time and funds allow, we will have an inactive group, i.e., a group of children who will keep their regular routine, without any intervention. We will collect their saliva samples in the same conditions used with the other groups.
Outcome in design-specific comparisons between highly crosslinked and conventional polyethylene in total hip arthroplasty
Creators: name: Per-Erik Johanson
name: Furnes, Ove
name: Havelin, Leif Ivar
name: Fenstad, Anne Marie
name: Pedersen, Alma B
name: Overgaard, Søren
name: Garellick, Göran
name: Mäkelä, Keijo
name: Kärrholm, Johan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background and purpose — Most registry studies regarding highly crosslinked polyethylene (XLPE) have focused on the overall revision risk. We compared the risk of cup and/or liner revision for specific cup and liner designs made of either XLPE or conventional polyethylene (CPE), regarding revision for any reason and revision due to aseptic loosening and/or osteolysis. Patients and methods — Using the Nordic Arthroplasty Register Association (NARA) database, we identified cup and liner designs where either XLPE or CPE had been used in more than 500 THAs performed for primary hip osteoarthritis. We assessed risk of revision for any reason and for aseptic loosening using Cox regression adjusted for age, sex, femoral head material and size, surgical approach, stem fixation, and presence of hydroxyapatite coating (uncemented cups). Results — The CPE version of the ZCA cup had a risk of revision for any reason similar to that of the XLPE version (p = 0.09), but showed a 6-fold higher risk of revision for aseptic loosening (p < 0.001). The CPE version of the Reflection All Poly cup had an 8-fold elevated risk of revision for any reason (p < 0.001) and a 5-fold increased risk of revision for aseptic loosening (p < 0.001). The Charnley Elite Ogee/Marathon cup and the Trilogy cup did not show such differences. Interpretation — Whether XLPE has any advantage over CPE regarding revision risk may depend on the properties of the polyethylene materials being compared, as well as the respective cup designs, fixation type, and follow-up times. Further research is needed to elucidate how cup design factors interact with polyethylene type to affect the risk of revision.
JaponicusDB: rapid deployment of a model organism database for an emerging model species
Creators: name: Rutherford, Kim M
name: Harris, Midori A
name: Oliferenko, Snezhana
name: Wood, Valerie
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Ecology,Evolution & Ethology
Cell Biology
Cell Cycle & Chromosomes

description: The fission yeast Schizosaccharomyces japonicus has recently emerged as a powerful system for studying the evolution of essential cellular processes, drawing on similarities as well as key differences between S. japonicus and the related, well-established model Schizosaccharomyces pombe. We have deployed the open-source, modular code and tools originally developed for PomBase, the S. pombe model organism database (MOD), to create JaponicusDB (www.japonicusdb.org), a new MOD dedicated to S. japonicus. By providing a central resource with ready access to a growing body of experimental data, ontology-based curation, seamless browsing and querying, and the ability to integrate new data with existing knowledge, JaponicusDB supports fission yeast biologists to a far greater extent than any other source of S. japonicus data. JaponicusDB thus enables S. japonicus researchers to realize the full potential of studying a newly emerging model species and illustrates the widely applicable power and utility of harnessing reusable PomBase code to build a comprehensive, community-maintainable repository of species-relevant knowledge.
XXI Международная научно-практическая конференция «Современные тенденции развития науки и мирового сообщества в эпоху цифровизации»
Creators: name: ООО "Институт развития образования и консалтинга"
Publisher: name: ООО "Институт развития образования и консалтинга"
Year: 2024

description: XXI Международная научно-практическая конференция «Современные тенденции развития науки и мирового сообщества в эпоху цифровизации»
Distribution and diversity of reptiles in Albania: a novel database from a Mediterranean hotspot. Supplementary Material
Creators: name: Edvárd Mizsei
name: Jablonski, Daniel
name: Végvári, Zsolt
name: Lengyel, Szabolcs
name: Szabolcs, Márton
Publisher: name: Brill Online
Year: 2017
Subjects: subject: Zoology
subject: FOS: Biological sciences
subject: 60207 Population Ecology

description: Although Albania has a rich reptile fauna, efforts to reveal its diversity have so far been limited. To fill this gap, we collected available published and unpublished (museum collections, online sources) records of reptile occurrences and conducted several expeditions to search for reptiles in areas with few or no previous records. Our georeferenced database contains 3731 records of 40 species from between 1918 and 2015. Based on this comprehensive dataset, we prepared distribution maps for each reptile species of the country. Applying spatial statistics, we revealed that overall sampling effort was clustered, with hotspots associated with easily accessible areas and natural heritage sites. The maximum number of species per cell was 26 with an average of seven. Cells harbouring large reptile diversity were located along the Adriatic and Ionian coasts, on the western slopes of south Albanian mountains, i.e. in areas generally considered as Balkans biodiversity hotspots or potential historical refugia. We found that species presence and diversity is strongly influenced by landscape features. Diversity of land cover, altitudinal variation, temperature and precipitation variation explained the observed pattern in our models. Our study presents the largest database of reptile occurrences to date and is the first to analyse reptile diversity patterns in Albania. The database and the diversity patterns can provide a basis for future macroecological studies and conservation planning.
title: Quelles interventions infirmières proposer pour optimiser la prise en soin d’un nouveau-né souffrant d’un syndrome de sevrage, survenu à la suite d’une prise d’opiacés de la mère durant la grossesse ?
title: Quelles interventions infirmières proposer pour optimiser la prise en soin d’un nouveau-né souffrant d’un syndrome de sevrage, survenu à la suite d’une prise d’opiacés de la mère durant la grossesse ?
titleType: AlternativeTitle
Creators: name: Chapuis, Joanne
name: Félix, Celia
name: Kurzen, Emilie
Publisher: name: Unknown
Year: 0
Subjects: subject: Opioïdes
subject: Grossesse
subject: Femme enceinte
subject: Néonatologie
subject: Soins infirmiers

description: La consommation d’opioïdes est en augmentation constante, en Suisse comme dans le monde. Cette problématique peut concerner toute personne, y compris les femmes enceintes. En effet, il arrive que des futures mamans consomment des opioïdes pendant leur grossesse que ce soit pour des problèmes d’addiction, ou à visée thérapeutique lors de maladies chroniques. Certains nouveau-nés ayant reçu des doses d’opiacés in utéro naissent alors avec de forts symptômes, causés par un syndrome de sevrage.
Outcome in design-specific comparisons between highly crosslinked and conventional polyethylene in total hip arthroplasty
Creators: name: Per-Erik Johanson
name: Furnes, Ove
name: Havelin, Leif Ivar
name: Fenstad, Anne Marie
name: Pedersen, Alma B
name: Overgaard, Søren
name: Garellick, Göran
name: Mäkelä, Keijo
name: Kärrholm, Johan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background and purpose — Most registry studies regarding highly crosslinked polyethylene (XLPE) have focused on the overall revision risk. We compared the risk of cup and/or liner revision for specific cup and liner designs made of either XLPE or conventional polyethylene (CPE), regarding revision for any reason and revision due to aseptic loosening and/or osteolysis. Patients and methods — Using the Nordic Arthroplasty Register Association (NARA) database, we identified cup and liner designs where either XLPE or CPE had been used in more than 500 THAs performed for primary hip osteoarthritis. We assessed risk of revision for any reason and for aseptic loosening using Cox regression adjusted for age, sex, femoral head material and size, surgical approach, stem fixation, and presence of hydroxyapatite coating (uncemented cups). Results — The CPE version of the ZCA cup had a risk of revision for any reason similar to that of the XLPE version (p = 0.09), but showed a 6-fold higher risk of revision for aseptic loosening (p < 0.001). The CPE version of the Reflection All Poly cup had an 8-fold elevated risk of revision for any reason (p < 0.001) and a 5-fold increased risk of revision for aseptic loosening (p < 0.001). The Charnley Elite Ogee/Marathon cup and the Trilogy cup did not show such differences. Interpretation — Whether XLPE has any advantage over CPE regarding revision risk may depend on the properties of the polyethylene materials being compared, as well as the respective cup designs, fixation type, and follow-up times. Further research is needed to elucidate how cup design factors interact with polyethylene type to affect the risk of revision.
Calling, texting, and searching for information while riding a motorcycle: A study of university students in Vietnam
Creators: name: Truong, Long T.
name: Gruyter, Chris De
name: Nguyen, Hang T. T.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objective: The objective of this study was to investigate the prevalence of calling, texting, and searching for information while riding a motorcycle among university students and the influences of sociodemographic characteristics, social norms, and risk perceptions on these behaviors. Methods: Students at 2 university campuses in Hanoi and Ho Chi Minh City, the 2 largest cities in Vietnam, were invited to participate in an anonymous online survey. Data collection was conducted during March and May 2016. Results: There were 741 respondents, of whom nearly 90% of students (665) were motorcycle riders. Overall prevalence of mobile phone use while riding is 80.9% (95% confidence interval [CI], 77.9–83.9%) with calling having a higher level of prevalence than texting or searching for information while riding: 74% (95% CI, 70.7–77.3%) vs. 51.7% (95% CI, 47.9–55.5%) and 49.9% (95% CI, 46.1–53.7%), respectively. Random parameter ordered probit modeling results indicate that mobile phone use while riding is associated with gender, motorcycle license duration, perceived crash risk, perceived risk of mobile phone snatching, and perceptions of friends' mobile phone use while riding. Conclusions: Mobile phone use while riding a motorcycle is highly prevalent among university students. Educational programs should focus on the crash and economic risk of all types of mobile phone use while riding, including calling, texting, and searching for information. In addition, they should consider targeting the influence of social norms and peers on mobile phone use while riding.
Attirer les investissements directs étrangers en Afrique sub-saharienne : Rôle de la facilitation des échanges au sein des administrations des douanes nationales
Creators: name: ADJANDE, Ali Awountchou
Publisher: name: Zenodo
Year: 2024
Subjects: IDE ; Facilitation des échanges ; Automatisation ; Couts commerciaux; Procédures douanières.

description: Cet article étudie les effets de la facilitation des échanges sur l’attractivité des investissements directs étrangers dans les pays de l’Afrique Sub-Saharienne (ASS) sur la période 2017-2022. A l’aide d’un modèle dynamique sur données de panel estimé par la méthode des moments généralisés (MMG), les principaux résultats montrent que la facilitation des échanges à travers l’automatisation des procédures douanières et la réduction des couts commerciaux en Afrique Sub-Saharienne améliorent l’attractivité des IDE dans cette région. Nos résultats suggèrent que les politiques commerciales des pays de l’ASS doivent intégrer des dispositions pratiques pour faciliter les échanges commerciaux.  Elles doivent également viser la modernisation des pratiques commerciales par l’adoption des programmes ambitieux d’automatisation des administrations douanières afin de faciliter les démarches administratives douanières.
Geometric morphometrics, scute patterns and biometrics of loggerhead turtles (Caretta caretta) in the central Mediterranean. Supplementary Material
Creators: name: Casale, Paolo
name: Freggi, Daniela
name: Rigoli, Alessandro
name: Ciccocioppo, Amedeo
name: Luschi, Paolo
Publisher: name: Brill Online
Year: 2017
Subjects: subject: Anatomy
subject: 60807 Animal Structure and Function
subject: FOS: Biological sciences
subject: Marine Biology
subject: Zoology

description: We investigate for the first time allometric vs. non-allometric shape variation in sea turtles through a geometric morphometrics approach. Five body parts (carapace, plastron, top and lateral sides of the head, dorsal side of front flippers) were considered in a sample of 58 loggerhead turtles (Caretta caretta) collected in the waters around Lampedusa island, Italy, the central Mediterranean. The allometric component was moderate but significant, except for the plastron, and may represent an ontogenetic optimization in the case of the head and flippers. The predominant non-allometric component encourages further investigation with sex and origin as potential explanatory variables. We also reported the variation of marginal and prefrontal scutes of 1497 turtles, showing that: variation of marginals is mostly limited to the two anteriormost scutes, symmetry is favored, asymmetry is biased to one pattern, and the variation of marginal and prefrontal scutes are linked. Comparisons with other datasets from the Mediterranean show a high variability, more likely caused by epigenetic factors. Finally, conversion equations between the most commonly used biometrics (curved and straight carapace length, carapace width, and weight) are often needed in sea turtle research but are lacking for the Mediterranean and are here estimated from a sample of 2624 turtles.
MGF E peptide pretreatment improves collagen synthesis and cell proliferation of injured human ACL fibroblasts via MEK-ERK1/2 signaling pathway
Creators: name: Sha, Yongqiang
name: Afandi, Ruli
name: Zhang, Bingbing
name: Yang, Li
name: Lv, Yonggang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Injured anterior cruciate ligament (ACL) is hard to heal due to the poor proliferative potential of ACL fibroblasts. To verify whether mechano-growth factor (MGF) E peptide can restore the cell proliferation of injured ACL fibroblasts, ACL fibroblasts pretreated with MGF E peptide were subjected to injurious stretch and the outcomes were evaluated at 0 and 24 h. After injured, the type III collagen synthesis was increased at 0 h while inhibited at 24 h. The matrix metalloproteinase-2 (MMP-2) activity/expression was up-regulated, but the cell proliferation was inhibited. Fortunately, exogenous MGF E peptide decreased the type I/III collagen synthesis at 0 h but improved the type III collagen synthesis at 24 h. It decreased the MMP-2 activity/expression of injured ACL fibroblasts. Besides, MGF E peptide accelerated the cell proliferation via MEK-ERK1/2 signaling pathway. Our results implied that MGF E peptide pretreatment could provide a new efficient approach for ACL regeneration.
Invisible Ethics: The Problem of Anonymity on the Internet
Creators: name: Abreu Ladeira Da Costa E Silva, Miguel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Anonymity
Internet
Ethics
Situational forces
Identity
Behavior

description: This thesis aims to shed some light on the way anonymity affects behavior online, as well as the moral implications this influence supposes for internet users. We do this in three chapters, each dedicated to a specific aspect that might be problematic, and look at the technical aspects of the influence of anonymity, as well as the psychological aspects of this influence. We begin by analyzing anonymity as a tool that gives rational actors an advantage over their peers. We then gage the extent to which it constitutes a situational force, and how it coordinates with other situational forces within the online environment. Finally, through an evaluation aided by moral psychology and the literature in ethics, we use a situationist approach to identify the two main ways in which we believe anonymity affects moral behavior in the internet.
Influence of peripheral alkyl chain length on the mesomorphic behaviours of hexasubstituted triphenylene 2,3-dicarboxylic esters
Creators: name: Han, Xi-Dan
name: Tian, Xian-Li
name: Yu, Wen-Hao
name: Xiang, Shi-Kai
name: Hu, Ping
name: Wang, Bi-Qin
name: Zhao, Ke-Qing
name: Chen, Xiao-Zhen
name: Feng, Chun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Virology

description: A comparative study of our established synthetic approaches to hexasubsituted triphenylenes 2,3-dicarboxylic esters containing four identical β-alkoxy and two adjacent β-alkoxycarbonyl side chains shows that the phase behaviours of small-sized discotic liquid crystals can be tailored over a wide range by simply varying the length of the peripheral alkyl chains. All the prepared esters in two series were observed to form a single hexagonal columnar phase, except for Tp4-1 having four β-butyloxy and two adjacent β-methoxycarbonyl chains which displays two columnar mesophase behaviours with a transition from the columnar plastic phase to hexagonal columnar phase. A significant difference between the two mesophase was observed in the variable temperature X-ray diffraction studies, and the mesophase assignment was also confirmed by polarising optical microscopy and differential scanning calorimetry. Moreover, the prepared esters in each series display the general trend of decreasing clearing temperature upon increasing alkoxy or alkoxycarbonyl chains length. The intermediate triphenylene 2,3-dicarboxylic acids were also found not only to exhibit columnar hexagonal mesophase over a narrower temperature range by maintaining high melting and clearing points but also to form organogel on mixing with toluene or dichloromethane with the assistance of hydrogen bonding.
Hot carrier extraction from 2D semiconductor photoelectrodes
Creators: name: Austin, Rachelle
name: Farah, Yusef
name: Sayer, Thomas
name: Luther, Brad M.
name: Montoya-Castillo, Andrés
name: Krummel, Amber
name: Sambur, Justin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Hot carrier-based energy conversion systems could double the efficiency of conventional solar energy technology or drive photochemical reactions that would not be possible using fully thermalized, ``cool'' carriers, but current strategies require expensive multi-junction architectures. Using an unprecedented combination of photoelectrochemical and in situ transient absorption spectroscopy measurements, we demonstrate ultrafast (<50 fs) hot exciton and free carrier extraction under applied bias in a proof-of-concept photoelectrochemical solar cell made from earth-abundant and potentially inexpensive monolayer (ML) MoS2. Our approach facilitates ultrathin 7Åcharge transport distances over 1 cm^2 areas by intimately coupling ML-MoS2 to an electron-selective solid contact and a hole-selective electrolyte contact. Our theoretical investigations of the spatial distribution of exciton states suggest greater electronic coupling between hot exciton states located on peripheral S atoms and neighboring contacts likely facilitates ultrafast charge transfer. Our work delineates future 2D semiconductor design strategies for practical implementation in ultrathin photovoltaic and solar fuels applications.
description: 6 pages, 3 figures main text; 6 pages, 8 figures, 1 table, 57 refs. appendices
Additional Discussion, Tables, and Figures from Discovery of the fossil otter Enhydritherium terraenovae (Carnivora, Mammalia) in Mexico reconciles a palaeozoogeographic mystery.
Creators: name: Tseng, Z. Jack
name: Pacheco-Castro, Adolfo
name: Carranza-Castañeda, Oscar
name: Aranda-Gómez, José Jorge
name: Wang, Xiaoming
name: Troncoso, Hilda
Publisher: name: The Royal Society
Year: 2017

description: The North American fossil otter Enhydritherium terraenovae is thought to be partially convergent in ecological niche with the living sea otter Enhydra lutris, both having low-crowned crushing teeth and a close association with marine environments. Fossil records of Enhydritherium are found in mostly marginal marine deposits in California and Florida; despite presence of very rich records of fossil terrestrial mammals in contemporaneous localities inland, no Enhydritherium fossils are hitherto known in interior North America. Here we report the first occurrence of Enhydritherium outside of Florida and California, in a land-locked terrestrial mammal fauna of the upper Miocene deposits of Juchipila Basin, Zacatecas State, Mexico. This new occurrence of Enhydritherium is at least 200 km from the modern Pacific coastline, and nearly 600 km from the Gulf of Mexico. Besides providing further evidence that Enhydritherium was not dependent on coastal marine environments as originally interpreted, this discovery leads us to propose a new east-to-west dispersal route between the Florida and California Enhydritherium populations through central Mexico. The proximity of the fossil locality to nearby populations of modern neotropical otters Lontra longicaudis suggests that trans-Mexican freshwater corridors for vertebrate species in riparian habitats may have persisted for a prolonged period of time, pre-dating the Great American Biotic Interchange.
Supplementary Material for: Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development
Creators: name: Hellmuth, C.
name: Uhl, O.
name: Standl, M.
name: Demmelmair, H.
name: Heinrich, J.
name: Koletzko, B.
name: Thiering, E.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aims: Fetal metabolism may be changed by the exposure to maternal factors, and the route to obesity may already set in utero. Cord blood metabolites might predict growth patterns and later obesity. We aimed to characterize associations of cord blood with birth weight, postnatal weight gain, and BMI in adolescence. Methods: Over 700 cord blood samples were collected from infants participating in the German birth cohort study LISAplus. Glycerophospholipid fatty acids (GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino acids were analyzed with a targeted, liquid chromatography-tandem mass spectrometry based metabolomics platform. Cord blood metabolites were related to growth factors by linear regression models adjusted for confounding variables. Results: Cord blood metabolites were highly associated with birth weight. Lysophosphatidylcholines C16:1, C18:1, C20:3, C18:2, C20:4, C14:0, C16:0, C18:3, GPL-FA C20:3n-9, and GPL-FA C22:5n-6 were positively related to birth weight, while higher cord blood concentrations of NEFA C22:6, NEFA C20:5, GPL-FA C18:3n-3, and PCe C38:0 were associated with lower birth weight. Postnatal weight gain and BMI z-scores in adolescents were not significantly associated with cord blood metabolites after adjustment for multiple testing. Conclusion: Potential long-term programming effects of the intrauterine environment and metabolism on later health cannot be predicted with profiling of the cord blood metabolome.
Additional Discussion, Tables, and Figures from Discovery of the fossil otter Enhydritherium terraenovae (Carnivora, Mammalia) in México reconciles a paleozoogeographic mystery
Creators: name: Tseng, Z. Jack
name: Pacheco-Castro, Adolfo
name: Carranza-Castañeda, Oscar
name: Aranda-Gómez, José Jorge
name: Wang, Xiaoming
name: Troncoso, Hilda
Publisher: name: The Royal Society
Year: 2017

description: The North American fossil otter Enhydritherium terraenovae is thought to be partially convergent in ecological niche with the living sea otter Enhydra lutris, both having low-crowned crushing teeth and a close association with marine environments. Fossil records of Enhydritherium are found in mostly marginal marine deposits in California and Florida; despite presence of very rich records of fossil terrestrial mammals in contemporaneous localities inland, no Enhydritherium fossils are hitherto known in interior North America. Here we report the first occurrence of Enhydritherium outside of Florida and California, in a land-locked terrestrial mammal fauna of the upper Miocene deposits of Juchipila Basin, Zacatecas State, México. This new occurrence of Enhydritherium is at least 200 km from the modern Pacific coastline, and more than 600 km from the Gulf of México. Besides providing further evidence that Enhydritherium is not dependent on coastal marine environments as originally interpreted, this discovery leads us to propose a new east-to-west dispersal route between the Florida and California Enhydritherium populations through central México. The proximity of the fossil locality to nearby populations of modern neotropical otters Lontra longicaudis suggests that trans-Mexican freshwater corridors for vertebrate species in riparian habitats may have persisted for a prolonged period of time, pre-dating the Great American Biotic Interchange.
Die Bedeutung der Gesellschafterliste für die zwangsweise Einziehung von GmbH-Geschäftsanteilen - Eine Untersuchung der Rechtsfolgen der Zwangseinziehung sowie Rechtsschutzmöglichkeiten des von der Zwangseinziehung betroffenen Gesellschafters unter besonderer Beachtung der Legitimationswirkung der Gesellschafterliste
Creators: name: Schulte, Tasja
Publisher: name: Universität Osnabrück
Year: 2022
Subjects: subject: Zwangseinziehung
subject: Gesellschafterliste
subject: Legitimationswirkung
subject: 340 - Recht
subject: 86.27 - Gesellschaftsrecht

description: Die Gesellschafter einer GmbH können die Möglichkeit zur zwangsweisen Einziehung eines Geschäftsanteils nach § 34 Abs. 2 GmbHG im Gesellschaftsvertrag statuieren. Sieht der Gesellschaftsvertrag die Möglichkeit zur zwangsweisen Einziehung eines Geschäftsanteils vor, können die Gesellschafter einen Mitgesellschafter, in dessen Person die Zwangseinziehungsvoraussetzungen eingetreten sind, einseitig durch Fassung eines Zwangseinziehungsbeschlusses und Erklärung der Einziehung gegenüber dem betroffenen Gesellschafter ausschließen. Da der Gesellschafter, in dessen Person der Zwangseinziehungsgrund eingetreten ist, einem Stimmrechtsverbot unterliegt, ist auch ein Mehrheitsgesellschafter vor der zwangsweisen Einziehung seines Geschäftsanteils nicht bewahrt. Entscheidender Vorteil der Zwangseinziehung gegenüber der Ausschlussklage analog § 140 HGB ist dabei deren Kurzfristigkeit. Gerade diese Kurzfristigkeit birgt im Zusammenwirken mit der Legitimationswirkung der Gesellschafterliste nach § 16 Abs. 1 S. 1 GmbHG weitreichende Missbrauchsgefahren durch die übrigen Gesellschafter. Fallen die materielle und die formale Gesellschafterstellung auseinander, ist nach § 16 Abs. 1 S. 1 GmbHG die formale Gesellschafterstellung für die Wahrnehmung der Mitgliedschaftsrechte und -pflichten maßgebend. Aufgrund dieser Wirkung droht ein Wettlauf zwischen den beteiligten Parteien - auf der einen Seite haben die verbleibenden Gesellschafter ein Interesse an der unverzüglichen Aktualisierung der Gesellschafterliste, auf der anderen Seite möchte der von der Zwangseinziehung betroffene Gesellschafter seine formale Gesellschafterstellung bewahren. Primäres Ziel der Arbeit ist es, die Einreichung und Aufnahme materiell fehlerhafter Gesellschafterlisten zu verhindern. Sekundär widmet sich die Verfasserin den Rechtsschutzmöglichkeiten des von der Zwangseinziehung betroffenen Gesellschafters gerichtet auf die Sicherung oder Wiederherstellung der formalen Gesellschafterstellung. Im Fokus steht der einstweilige Rechtsschutz.
Palaeoboganium gen. nov. from the Middle Jurassic of China (Coleoptera: Cucujoidea: Boganiidae): the first cycad pollinators?
Creators: name: Zhenhua Liu
name: Ślipiński, Adam
name: Lawrence, John F.
name: Ren, Dong
name: Pang, Hong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Palaeoboganium jurassicum gen. et sp. nov. is described from the Middle Jurassic Daohugou formation in northern China. Palaeoboganium jurassicum is the first fossil representative of the enigmatic family Boganiidae, currently known from Gondwanan localities in South Africa, Australia and New Caledonia. Based on a phylogenetic analysis of adult external characters, Palaeoboganium is recovered as the sister group of Paracucujus Sen Gupta & Crowson and Metacucujus Endrödy-Younga & Crowson (Paracucujinae), whose adults pollinate cycads in Australia and South Africa. Based on phylogenetic evidence this taxon is suggested to be a potential pollinator of Jurassic cycads. http://zoobank.org/urn:lsid:zoobank.org:pub:7EDB8295-5EF3-40ED-9A84-479AD23611AF
A new sesquiterpene lactone glucoside and other constituents from Inula salsoloides with insecticidal activities on striped flea beetle (Phyllotreta striolata Fabricius)
Creators: name: Bai, Lu
name: Liu, Qingchao
name: Cen, Yijing
name: Huang, Jinping
name: Zhang, Xinxin
name: Guo, Sen
name: Zhang, Li
name: Guo, Tiantian
name: Ho, Chi-Tang
name: Bai, Naisheng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: A new sesquiterpene, eupatolide 13-O-β-d-glucopyranoside (eupatolide-II, 1), lactone glucoside, along with 15 known compounds, were isolated from the whole plant of Inula salsoloides (Asteraceae). Dichloromethane extract and compounds 1–11 were used to investigate insecticidal activities against vegetable important pest, striped flea beetle (Phyllotreta striolata Fabricius). None of the samples show any toxicity under concentration of 500 times, while compound 1 and the extract had toxic effect when the concentration increased to 250 times. But the corrected mortality of compound 1 and the extract were only 44.83 and 13.80%, respectively. Compound 11 (inulasalene) showed repellency effect in the no-choice test, and the repellency rate was 70%. Compounds 1 and 3 (inulasalsolide) showed the antifeeding rates of 65.22 and 47.06%, respectively. Compound 10 (11β,13-dihydrogeneupatolide) showed strong attractive effects on the adults, while the difference of injured area between the treatment and control was also not significant.
Investigations of FAK inhibitors: a combination of 3D-QSAR, docking, and molecular dynamics simulations studies
Creators: name: Cheng, Peng
name: Li, Jiaojiao
name: Wang, Juan
name: Zhang, Xiaoyun
name: Zhai, Honglin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Space Science
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Developmental Biology
Cancer

description: Focal adhesion kinase (FAK) is one kind of tyrosine kinases that modulates integrin and growth factor signaling pathways, which is a promising therapeutic target because of involving in cancer cell migration, proliferation, and survival. To investigate the mechanism between FAK and triazinic inhibitors and design high activity inhibitors, a molecular modeling integrated with 3D-QSAR, molecular docking, molecular dynamics simulations, and binding free energy calculations was performed. The optimum CoMFA and CoMSIA models showed good reliability and satisfactory predictability (with Q2 = 0.663, R2 = 0.987,  = 0.921 and Q2 = 0.670, R2 = 0.981,  = 0.953). Its contour maps could provide structural features to improve inhibitory activity. Furthermore, a good consistency between contour maps, docking, and molecular dynamics simulations strongly demonstrates that the molecular modeling is reliable. Based on it, we designed several new compounds and their inhibitory activities were validated by the molecular models. We expect our studies could bring new ideas to promote the development of novel inhibitors with higher inhibitory activity for FAK.
strongERP
Creators: name: Bauer, Robert
Publisher: name: figshare
Year: 2017
Subjects: subject: 90609 Signal Processing
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Fake ERP generated with MCS STG 4008, the waveform defined by fake_erp.dat and with large amplitude