cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Association of pre-existing comorbidities with outcome of allogeneic hematopoietic cell transplantation. A retrospective analysis from the EBMT
Creators: name: Penack, Olaf
name: Peczynski, Christophe
name: Mohty, Mohamad
name: Yakoub-Agha, Ibrahim
name: Camara, Rafael De La
name: Glass, Bertram
name: Duarte, Rafael F.
name: Kröger, Nicolaus
name: Schoemans, Hélène
name: Koenecke, Christian
name: Peric, Zinaida
name: Basak, Grzegorz W.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: allogeneic hematopoietic cell transplantation (allo-HCT)
subject: comorbidities
subject: European Society for Blood and Marrow Transplantation (EBMT)
subject: risk assessment
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Risk assessment of allogeneic hematopoietic cell transplantation (allo-HCT) is hindered by the lack of current data on comorbidities and outcome. The EBMT identified 38,760 allo-HCT recipients with hematologic malignancies transplanted between 2010 and 2018 from matched sibling and unrelated donors with a full data set of pre-existing comorbidities. Multivariate analyses using the Cox proportional-hazards model including known risk factors for non-relapse mortality (NRM) were performed. We found that pre-existing renal comorbidity had the strongest association with NRM (hazard ratio [HR] 1.85 [95% CI 1.55-2.19]). In addition, the association of multiple pre-existing comorbidities with NRM was significant, including diabetes, infections, cardiac comorbidity, and pulmonary comorbidity. However, the HR of the association of these comorbidities with NRM was relatively low and did not exceed 1.24. Consequently, the risk of NRM was only moderately increased in patients with a high hematopoietic cell transplantation comorbidity index (HCT-CI) >= 3 (HR 1.34 [1.26-1.42]). In the current EBMT population, pre-existing non-renal comorbidities determined NRM after allo-HCT to a much lesser extent as compared with the underlying HCT-CI data. Improvements in management and supportive care as well as higher awareness based on the use of HCT-CI may have contributed to this favorable development.
MASOFAVIY DARSLARDA METAKOGNITIV STRATEGIYALARDAN FOYDALANISH
Creators: name: Farmonov, Dilshod
name: Nigmatov, Izzat
Publisher: name: Zenodo
Year: 2025

description: Taraqqiy etishning yagona yo‘li – bu ta’lim orqali amalga oshiriladi. Dunyoda sodir bo‘layotgan voqealar qaysidir sohalarni rivojlantirsa, yana qaysidir soha mutaxassislarining ish o‘rnini qisqarishiga sabab bo‘lmoqda. COVID-19 pandemiyasi barcha soha uchun katta sinov bo‘ldi, jumladan, ta’lim sohasi uchun ham. Pandemiya davrigacha ta’limni yuzma-yuz, ana’naviy shakli tan olinar edi. Garchi, onlayn ta’lim mavjud bo‘lsada, undan foydalanishga e’tiborsizlik va ishonchsizliklar yuqori edi. Chunki, o‘quvchilar mustaqil izlanishlari va ishlari, o‘z bilishlari uchun javobgarlikni his etishlari hamda ichki motivlari sabab ta’lim olishlari kerak edi. Onlayn darslar yoki ustozlar ta’lim olishda bir vosita sifatida bo‘lishi kerak.
Supplementary document for Characterization of on-chip cavity coupled emission of 2D materials at room temperature - 6314972.pdf
Creators: name: Granados-Baez, Marissa
name: MUKHERJEE, ARUNABH
name: Qiu, Liangyu
name: Vamivakas, Nickolas
name: Cardenas, Jaime
name: Chakraborty, Chitraleema
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Material
[Letter from Hu Shiyuan to Hu Shiding]
[胡世元致胡世定的信]
Creators: name: Hu, Shiyuan
Publisher: name: The University of British Columbia
Year: 2011

description: In the letter, Hu Shiyuan tells Hu Shiding the cannery's production situation and that Hu Shiguang is going to work for another cannery starting from the following Tuesday.
From Johann to Maurice: Science and Expression in the Philosophical Praxis of Medicine
Creators: name: Heinbokel, Timm
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Phenomenology
subject: Maurice Merleau-Ponty
subject: Medicine
subject: Science
subject: Physician-patient encounter
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Phenomenology's return to lived experience and "to the things themselves" is often contrasted with the synthesized perspective of science and its "view from nowhere." The extensive use of neuropsychological case reports in Merleau-Ponty's Phenomenology of Perception, however, suggests that the relationship between phenomenology and science is more complex than a sheer opposition, and a fruitful one for the praxis of medicine. Here, I propose a new reading of how Merleau-Ponty justifies his use of Adhemar Gelb and Kurt Goldstein's reports on Johann Schneider for his phenomenology of embodied perception. I argue that for Merleau-Ponty these neuropsychological case reports represent a coherent deformation of the intercorporeally expressed existence of Schneider that through speech fall again onto the common ground of perception, thereby allowing Merleau-Ponty to understand, in the equivalent sense delivered by language, Schneider's total being and fundamental illness. I then discuss what Merleau-Ponty's method implies for a phenomenological praxis of medicine, and for the role of science in this praxis.
Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug Analysis
Creators: name: Hirschfeld, Tim
name: Smit-Rigter, Laura
name: Gouwe, Daan Van Der
name: Reiche, Simon
name: Stöver, Heino
name: Majić, Tomislav
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Serotonergic psychedelics
subject: New psychoactive substances
subject: NBOMes
subject: Drug checking
subject: Harm reduction
subject: Drug monitoring
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review With the continuous emergence of new psychoactive substances, drug checking (DC) services are challenged by an increasingly complex drug market. Considering the resumed scientific and public interest in serotonergic psychedelics (SPs) like LSD, psilocybin, and 2C-B, we present the results of a literature search investigating the presence and proportion of SPs in DC samples. Recent Findings: In 15 identified reports, submission and detection rates of SPs were comparably low, but increasing. Samples contained considerable amounts of adulterations or analogues, mostly novel SPs with unknown toxicological profiles and in some cases potentially life-threatening effects. The detection of SPs, however, requires advanced analysis techniques currently not available to most DC services. Summary: Given the substantial proportion of novel SPs in DC samples and the associated risks, DC can be a valuable harm reduction and monitoring tool for SPs if analysis techniques with high sensitivity are employed.
Supplementary document for Higher speed (> 10 MHz), wider angle linear electro-optic deflection via domain engineered KTN crystals - 6315016.pdf
Creators: name: Yin, Shizhuo
name: Shang, Annan
name: Liu, Ruijia
name: Lee, Yun Goo
name: KABIR, MOHAMMAD AHSANUL
name: Ji, Yaoyang
name: Wu, Kaicheng
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Experiment Setup and Linear EO coefficient
Anatomical Joint Form Variation in Sacroiliac Joint Disease: Current Concepts and New Perspectives
Creators: name: Ziegeler, Katharina
name: Hermann, Kay Geert A.
name: Diekhoff, Torsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Sacroiliac joint
subject: Anatomical variation
subject: Axial spondyloarthritis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose of Review: The aim of this article is to further the understanding of anatomical variation of the sacroiliac joint (SIJ) within the rheumatological community and point out promising fields of research in the interplay of SIJ anatomy and joint disease. Recent Findings: Mechanical strain has long been implicated in onset and progression of axial spondyloarthritis (axSpA). Recent investigations found changes in the pattern of degenerative lesions of the SIJ in the normal population in patients with atypical joint forms. Furthermore, atypical SIJ forms are more prevalent in patients with axial spondyloarthritis and mechanical SIJ disease. Mechanical stress from anatomical joint form variation may have an impact on development and progression of axSpA. Furthermore, mechanically induced bone marrow edema may act as an axSpA mimic on MRI and needs to be more accurately classified.
title: Endlich-dimensionale Nichols-Algebren von Diagonalem Typ über Körpern von positiver Charakteristik
title: Finite dimensional Nichols algebras of diagonal type over fields of positive characteristic
title: Finite dimensional Nichols algebras of diagonal type over fields of positive characteristic
Creators: name: Wang, Jing
Publisher: name: Philipps-Universität Marburg
Year: 2016
Subjects: subject: Weyl groupoid
subject: Weyl-Gruppoid
subject: root system
subject: Nichols-Algebra, Cartan-Graph
subject: Cartan graph
subject: Hopf-Algebra
subject: das Wurzelsystem
subject: Mathematics
subject: FOS: Mathematics
subject: Mathematik
subject: Hopf algebra, Nichols algebra

description: In dieser Arbeit gelingt es uns,
      die endlich dimensionalen Nichols-Algebren von diagonalem Typ
      über Körpern von positiver Charakteristik zu klassifizieren.
      Das vollständige Ergebnis kann durch Induktion über den Rang
      von Nichols-Algebren gegeben werden.
description: In this thesis we classify the rank
      2 and rank 3 Nichols algebras of diagonal type with a finite
      root system over fields of positive characteristic.
Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?
Creators: name: Wagner, Dimitrios Laurin
name: Peter, Lena
name: Schmueck-Henneresse, Michael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: gene therapy
subject: regulatory T cells (Treg)
subject: immune tolerance in humans
subject: Cas9
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The dichotomic nature of the adaptive immune response governs the outcome of clinical gene therapy. On the one hand, neutralizing antibodies and cytotoxic T cells can have a dramatic impact on the efficacy and safety of human gene therapies. On the other hand, regulatory T cells (Treg) can promote tolerance toward transgenes thereby enabling long-term benefits of in vivo gene therapy after a single administration. Pre-existing antibodies and T cell immunity has been a major obstacle for in vivo gene therapies with viral vectors. As CRISPR-Cas9 gene editing advances toward the clinics, the technology's inherent immunogenicity must be addressed in order to guide clinical treatment decisions. This review summarizes the recent evidence on Cas9-specific immunity in humans-including early results from clinical trials-and discusses the risks for in vivo gene therapies. Finally, we focus on solutions and highlight the potential role of Cas9-specific Treg cells to promote immune tolerance. As a "beneficial alliance" beyond Cas9-immunity, antigen-specific Treg cells may serve as a living and targeted immunosuppressant to increase safety and efficacy of gene therapy.
Unklare chronische Schwindelsyndrome – Erfahrungen mit einem interdisziplinären stationären Diagnostikkonzept
Creators: name: Münst, J.
name: Pudszuhn, Annett
name: Bernstorff, Maximilian Von
name: Obermueller, Theresa
name: Erdur, Hebun
name: Audebert, Heinrich J.
name: Rose, Matthias
name: Reisshauer, Anett
name: Hoffmann, Isabelle
name: Schönfeld, Uwe
name: Hofmann, Veit Maria
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Vestibular neuritis
subject: Interdisciplinary vertigo diagnostics
subject: Vestibular neuropathy
subject: Functional vertigo
subject: BPPV
subject: Cervical dizziness
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Dizziness is a common leading symptom. Especially patients with chronic vertigo syndromes experience a significant impairment in quality of life up to a limitation of their ability to work in the case of employed persons. The consequences are financial and capacitive burdens on the health system due to frequently multiple examinations and sick leave up to occupational invalidity of the affected patient. In 150 patients with chronic vertigo syndromes and an unclear outpatient diagnosis, at least one diagnosis that justified the complaint was made in over 90% of cases on the basis of a structured interdisciplinary inpatient diagnostic concept. Chronic vertigo syndromes are often multifactorial. Psychosomatic (accompanying) diagnoses were found in more than half of the patients. Targeted therapy can only be recommended after establishing a specific diagnosis. This justifies an interdisciplinary inpatient diagnostic concept for persistently unclear cases.
Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma
Creators: name: Cornelius, Anna
name: Pilger, Daniel
name: Riechardt, Aline
name: Reitemeyer, Emanuel
name: Rübsam, Anne
name: Winterhalter, Sibylle
name: Maier, Anna-Karina B.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Pseudoexfoliation glaucoma
subject: Primary open-angle glaucoma
subject: OCT angiography
subject: Peripapillary vessel density
subject: Macular vessel density
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: To compare the blood flow situation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) using optical coherence tomography angiography (OCTA). Methods: In this prospective study a total of 26 POAG and 23 PXG eyes were included. All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters. Results: The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57% +/- 3.57% vs. 34.92% +/- 2.11%, p = 0.007). The mean PD parameters for the superficial peripapillary plexus (40.98% +/- 3.04% vs. 42.09% +/- 2.29%, p = 0.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm(2) +/- 0.1 mm(2) vs. 0.23 mm(2) +/- 0.09 mm(2)) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97% +/- 1.11% vs. 33.35% +/- 0.95%, p = 0.194) and peripapillary plexus PD (46.65% +/- 0.83% vs. 46.95% +/- 0.5%, p = 0.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (p < 0.001, p = 0.032). Conclusion: The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.
title: Functionalization of inorganic semiconductors by advanced nanostructures
title: Funktionalisierung von inorganischen Halbleitern durch neuartige Nanostrukturen
Creators: name: Rosemann, Nils
Publisher: name: Philipps-Universität Marburg
Year: 2016
Subjects: Cluster molecules, Nanostructures
Physics
Physik
Nonlinear optics
Nichtlineare Optik , Frequenzumsetzung
Cluster
Frequency conversion
Optik , Laserspektroskopie

description: Different concepts for the
      functionalization of inorganic semiconductors are
      investigated. These include functionalization by gallium
      nitride based nanowires as well as functionalization by
      organotetrel cluster-molecules. The nanowires are
      investigated by time-resolved photoluminescence and external
      quantum efficiency measurements. The cluster-molecules are
      investigated in regards to their stability and nonlinear
      optical properties. Ultimately a cluster-molecule with an
      ultra-low threshold is found that provides supercontinuum
      generation using a continous-wave laser diode. For a better
      understaning of the white-light generating process,
      nummerical simulations based on a semi-classical model are
      performed.
description: Verschiedene Konzepte zur
      Funktionalisierung von anorganischen Halbleitern werden
      untersucht. Zu diesen Konzepten gehört die Funktionalisierung
      durch auf Galliumnitrid basierte Nanodrähte, genauso wie die
      Funktionalisierung mittels Organtetrel basierten
      Cluster-Molekülen. Die Nanodrähte werden mittel
      zeitaufgelöster Photoelektronenspektroskopie und Messungen
      der externen Quanteneffizienz untersucht. Die
      Cluster-Moleküle werden hinsichtlich ihrer Stabilität und
      nichtlinearen optischen Eigenschaften untersucht. Letzten
      Endes wird ein Cluster-Molekül gefunden welches eine extrem
      niedrige Schwelle für nichtlineare Prozesse aufweist. Diese
      niedrige Schwelle ermöglicht Supercontinuumserzeugung durch
      eine dauerstrich Laserdiode. Um den Prozess der
      Supercontinuumserzeugung in den Molekülen besser zu verstehen
      werden eine Reihe von nummerischen Simulationen. basierend
      auf einem halb-klassischen Model, durchgeführt.
Complete lung agenesis caused by complex genomic rearrangements with neo-TAD formation at the SHH locus
Creators: name: Melo, Uirá Souto
name: Piard, Juliette
name: Fischer-Zirnsak, Björn
name: Klever, Marius-Konstantin
name: Schöpflin, Robert
name: Mensah, Martin Atta
name: Holtgrewe, Manuel
name: Arbez-Gindre, Francine
name: Martin, Alain
name: Guigue, Virginie
name: Gaillard, Dominique
name: Landais, Emilie
name: Roze, Virginie
name: Kremer, Valerie
name: Ramanah, Rajeev
name: Cabrol, Christelle
name: Harms, Frederike L.
name: Kornak, Uwe
name: Spielmann, Malte
name: Mundlos, Stefan
name: Maldergem, Lionel Van
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Complete lung agenesis
subject: complex genomic rearrangement
subject: neo‑TAD
subject: SHH locus
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: During human organogenesis, lung development is a timely and tightly regulated developmental process under the control of a large number of signaling molecules. Understanding how genetic variants can disturb normal lung development causing different lung malformations is a major goal for dissecting molecular mechanisms during embryogenesis. Here, through exome sequencing (ES), array CGH, genome sequencing (GS) and Hi-C, we aimed at elucidating the molecular basis of bilateral isolated lung agenesis in three fetuses born to a non-consanguineous family. We detected a complex genomic rearrangement containing duplicated, triplicated and deleted fragments involving the SHH locus in fetuses presenting complete agenesis of both lungs and near-complete agenesis of the trachea, diagnosed by ultrasound screening and confirmed at autopsy following termination. The rearrangement did not include SHH itself, but several regulatory elements for lung development, such as MACS1, a major SHH lung enhancer, and the neighboring genes MNX1 and NOM1. The rearrangement incorporated parts of two topologically associating domains (TADs) including their boundaries. Hi-C of cells from one of the affected fetuses showed the formation of two novel TADs each containing SHH enhancers and the MNX1 and NOM1 genes. Hi-C together with GS indicate that the new 3D conformation is likely causative for this condition by an inappropriate activation of MNX1 included in the neo-TADs by MACS1 enhancer, further highlighting the importance of the 3D chromatin conformation in human disease.
Supplementary document for Microlens-assisted dark-field microscopy based on a fully immersed low refractive index microlens - 6315940.pdf
Creators: name: Wang, Jianguo
name: Jiang, Rui
name: Yang, Songlin
name: Cao, Yurong
name: Ye, Yong-Hong
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
The non-invasive assessment of myocardial work by pressure-strain analysis: clinical applications
Creators: name: Abawi, Dawud
name: Rinaldi, Tommaso
name: Faragli, Alessandro
name: Pieske, Burkert
name: Morris, Daniel A.
name: Kelle, Sebastian
name: Tschöpe, Carsten
name: Zito, Concetta
name: Alogna, Alessio
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Non-invasive pressure-strain analysis
subject: Myocardial work
subject: Myocardial mechanics
subject: Echocardiography
subject: Strain
subject: Speckle tracking
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Pressure-volume (PV) analysis is the most comprehensive way to describe cardiac function, giving insights into cardiac mechanics and energetics. However, PV analysis still remains a highly invasive and time-consuming method, preventing it from integration into clinical practice. Most of the echocardiographic parameters currently used in the clinical routine to characterize left ventricular (LV) systolic function, such as LV ejection fraction and LV global longitudinal strain, do not take the pressure developed within the LV into account and therefore fall too short in describing LV function as a hydraulic pump. Recently, LV pressure-strain analysis has been introduced as a new technique to assess myocardial work in a non-invasive fashion. This new method showed new insights in comparison to invasive measurements and was validated in different cardiac pathologies, e.g., for the detection of coronary artery disease, cardiac resynchronization therapy (CRT)-response prediction, and different forms of heart failure. Non-invasively assessed myocardial work may play a major role in guiding therapies and estimating prognosis. However, its incremental prognostic validity in comparison to common echocardiographic parameters remains unclear. This review aims to provide an overview of pressure-strain analysis, including its current application in the clinical arena, as well as potential fields of exploitation.
Cost analysis of inguinal hernia repair: the influence of clinical and hernia-specific factors
Creators: name: Aydin, Mustafa
name: Fikatas, Panagiotis
name: Denecke, Christian
name: Pratschke, Johann
name: Raakow, Jonas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Hernia repair
subject: Hernia cost
subject: Cost calculation
subject: Multimorbidity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: As in the rest of the world, in Germany, inguinal hernia operations are among the most common operations. From an economic standpoint, very little is known about the influence of demographic, clinical or hernia-related parameters on the cost of inguinal hernia repair. We, therefore, evaluated individual patient parameters associated with higher costs with a special focus on multimorbidity. Methods: A total of 916 patients underwent hernia repair for primary or recurrent inguinal hernia between 2014 and 2017 at a single university center and were included in the analysis. The clinical and financial data of these patients were analyzed to identify cost-increasing parameters. Results: A majority of patients were male (90.7%), with a mean age of 55 years. The surgical methods utilized were mainly the TAPP (57.2%) and Lichtenstein (41.7%) procedures, with an average duration of surgery of 85 min and an average duration of anesthesia of 155 min. The mean cost of all procedures was 3338.3 euro (+/- 1608.1 euro). Older age, multimorbidity, emergency operations with signs of incarceration, longer hospital stays and postoperative complications were significant cost-driving factors. On the other hand, sex, the side of the hernia (left vs. right) and the presence of recurrent hernias had no influence on the overall direct costs. Conclusion: From a purely economic point of view, older age and multimorbidity are demographic cost-driving factors that cannot be influenced. The national hospital reimbursement system needs to consider and compensate for these factors. Emergency operations need to be prevented by early elective treatment. Long postoperative stays and postoperative complications need to be prevented by proper preoperative check-ups and accurate treatment.
title: Lacking Evidence to Recommend Neoadjuvant Chemotherapy and Definitive Radiotherapy in Muscle-Invasive Bladder Cancer
title: In response to: Trimodality Therapy for Muscle-Invasive Bladder Cancer: Recent Advances and Unanswered Questions published by Di Maria Jiang et al. Current Oncology Reports 2020, https://doi.org/10.1007/s11912-020-0880-5
titleType: Subtitle
Creators: name: Böhmer, Dirk
name: Grün, Arne
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Bladder cancer
subject: Trimodality treatment
subject: Neoadjuvant chemotherapy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: We comment on the paper of Di Maria Jiang et al. published in Current Oncology Reports 2020, https://doi.org/10.1007/s11912020-0880-5. We disagree on a major recommendation of the authors because of lacking evidence. This response is considered to be important for readers of Current Oncology Reports.
COVID-19—from mucosal immunology to IBD patients
Creators: name: Weidinger, Carl
name: Hegazy, Ahmed Nabil
name: Glauben, Rainer
name: Siegmund, Britta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: COVID-19
subject: Host-Pathogen Interactions
subject: Inflammatory Bowel Diseases
subject: Intestinal Mucosa
subject: SARS-CoV-2
subject: Severity of Illness Index
subject: Symptom Assessment
subject: Virus Internalization
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.
Surgery due to mechanical bowel obstruction in relapsed ovarian cancer: clinical and surgical results of a bicentric analysis of 87 patients
Creators: name: Armbrust, Robert
name: Chekerov, Radoslav
name: Sander, S.
name: Biebl, M.
name: Chopra, S.
name: Krell, Jonathan
name: Rinne, Natasha
name: Nixon, Katherine
name: Fotopoulou, Christina
name: Sehouli, Jalid
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Recurrent ovarian cancer
subject: Salvage surgery
subject: Ileus
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Introduction: Mechanical bowel obstruction is a frequent acute and life-threatening event in relapsed ovarian cancer. Salvage surgery after failure of all conservative approaches, resulting in short bowel syndrome (SBS) constitutes a therapeutic dilemma. Our aim was to evaluate patients' surgical and clinical outcome in these highly palliative situations. Previous, limited, data reported a high morbidity and mortality. However, recent surgical and therapeutical improvements in relapsed ovarian cancer (ROC) offer better identification of patients who might benefit from surgery in an effort to extend the window of opportunity to subsequently offer these patients novel systemic therapeutic approaches. Material and methods: All subsequent ROC patients between 2012 and 2017 with acute mechanical bowel obstruction who underwent salvage extraperitoneal en bloc intestinal resection were retrospectively identified. Data were collected from two ESGO certified Ovarian Cancer Centers of Excellence (Charite Berlin and Imperial College London) and systematically evaluated regarding surgical and clinical outcomes. Results: Overall, 87 ROC patients were included in the analysis (median age 56 years, range 24-88), 47% were platinum resistant. High grade serous was the most common histology (76%) while most of the patients (67%) had at least two previous lines of treatment. Mean observed OS was 7.8 months. After salvage surgery, 46% of the patients had a residual small bowel length < 180 cm and 18% > 180 cm resulting in 41% in need of total parental nutrition. In 80% of the patients a permanent stoma was necessary. 30d morbidity and mortality was 74% and 10%, respectively. More than half of the patients were able to receive further courses of chemotherapy after surgery. Discussion: Salvage surgery for bowel obstruction in ROC patients needs careful consideration and identification of optimal surgical candidates to have the maximal therapeutic benefit. Despite the challenging morbidity profile, most patients managed to proceed to subsequent novel and conventional systemic treatment and so have their window of therapeutic opportunity extended.
Supplementary document for Enhanced Surface Second Harmonic Generation in Nanolaminates - 6315953.pdf
Creators: name: Abtahi, Fatemeh
name: Paul, Pallabi
name: Beer, Sebastian
name: Kuppadakkath, Athira
name: Pakhomov, Anton
name: Szeghalmi, Adriana
name: Nolte, Stefan
name: Setzpfandt, Frank
name: Eilenberger, Falk
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: 484893
title: Beneke, Rudolf
title: Catalogus Professorum Halensis
titleType: Subtitle
title: Biografienportal Sachsen-Anhalt
titleType: Other
Creators: name: Catalogus Professorum Halensis
name: Eberle, Henrik
Publisher: name: Historisches Datenzentrum Sachsen-Anhalt,Institut für Landesgeschichte (Sachsen-Anhalt)
Year: 2025
Subjects: subject: History
classificationCode: 4023025-9
subject: Halle (Saale)
valueUri: https://d-nb.info/gnd/4023025-9
classificationCode: 4006804-3
subject: Biografie
valueUri: https://d-nb.info/gnd/4006804-3
classificationCode: 4166546-6
subject: Landesgeschichte
valueUri: https://d-nb.info/gnd/4166546-6
classificationCode: 4051181-9
subject: Sachsen-Anhalt
valueUri: https://d-nb.info/gnd/4051181-9
classificationCode: 1048495779
subject: Universität Halle (Saale) | Halle (Saale)
valueUri: https://d-nb.info/gnd/1048495779
classificationCode: 2024276-1
subject: Martin-Luther-Universität Halle-Wittenberg | Halle (Saale); Wittenberg
valueUri: https://d-nb.info/gnd/2024276-1
classificationCode: 4020517-4
subject: Geschichte
valueUri: https://d-nb.info/gnd/4020517-4
classificationCode: 7504326-9
subject: Universitätsgeschichte
valueUri: https://d-nb.info/gnd/7504326-9
classificationCode: 7504427-4
subject: Wissenschaftsgeschichte
valueUri: https://d-nb.info/gnd/7504427-4
subject: Biografienportal Sachsen-Anhalt
subject: Catalogus Professorum Halensis
classificationCode: 120134756
subject: Eberle, Henrik | 1970– | Historiker
valueUri: https://d-nb.info/gnd/120134756
classificationCode: 116120312
subject: Beneke, Rudolf | 1861–1946 | Pathologe; Arzt; Hochschullehrer
valueUri: https://d-nb.info/gnd/116120312

description: Das Biografienportal Sachsen-Anhalt versammelt in Erst- und Zweitveröffentlichung oder zu Zwecken der Langzeitarchivierung Biografien von Menschen aus und in Sachsen-Anhalt. Integriert wurde der Catalogus Professorum Halensis, der durch Mitarbeitende des Instituts für Geschichte der Martin-Luther-Universität Halle-Wittenberg entstand. Dabei handelt es sich um ein bio-bibliografisches Online-Lexikon zu den Professoren der Universität Halle zwischen 1694 und 1968. Die Texte wurden vor allem von Henrik Eberle und anderen Mitarbeitenden zwischen 2005 und 2010 recherchiert und erstellt. Etliche Artikel zum Zeitraum 1694 bis 1817 verfasste Julia Schopferer. Bei der Überführung in das Biografienportal wurden die Lebensangaben neu recherchiert und Metadaten über Verfahren des Named Entity Recogniton erschlossen. Automatisiert erkannt wurden Personennamen, Ortsbezeichnungen und Körperschaften, die in der hier vorhandenen RTF-Datei indexiert vorliegt. Zudem wurden diese mit GND-Einträgen abgeglichen. Weiterhin erfolgte ein Abgleich mit der „Ontologie der historischen, deutschsprachigen Amts- und Berufsbezeichnungen“. Die Texte liegen im Jahr 2024 in zweifacher Ausgabe im Catalogus Professorum Halensis des Universitätsarchivs und des Biografienportals des Historischen Datenzentrums Sachsen-Anhalts vor. Sie werden hier für die Langzeitarchivierung der ursprünglichen Fassung archiviert.
description: https://www.catalogus-professorum-halensis.de/
description: Biografienportal Sachsen-Anhalt: https://www.histdata.uni-halle.de/
Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection
Creators: name: Goetzke, Carl Christoph
name: Althof, Nadine
name: Neumaier, Hannah Louise
name: Heuser, Arndt
name: Kaya, Ziya
name: Kespohl, Meike
name: Klingel, Karin
name: Beling, Antje
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Infection
subject: Proteasome
subject: Inflammation
subject: Cytokine
subject: Myocarditis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: A preclinical model of troponin I-induced myocarditis (AM) revealed a prominent role of the immunoproteasome (ip), the main immune cell-resident proteasome isoform, in heart-directed autoimmunity. Viral infection of the heart is a known trigger of cardiac autoimmunity, with the ip enhancing systemic inflammatory responses after infection with a cardiotropic coxsackievirusB3 (CV). Here, we used ip-deficient A/J-LMP7(-/-) mice to investigate the role of ip-mediated effects on adaptive immunity in CV-triggered myocarditis and found no alteration of the inflammatory heart tissue damage or cardiac function in comparison to wild-type controls. Aiming to define the impact of the systemic inflammatory storm under the control of ip proteolysis during CV infection, we targeted the ip in A/J mice with the inhibitor ONX 0914 after the first cycle of infection, when systemic inflammation has set in, well before cardiac inflammation. During established acute myocarditis, the ONX 0914 treatment group had the same reduction in cardiac output as the controls, with inflammatory responses in heart tissue being unaffected by the compound. Based on these findings and with regard to the known anti-inflammatory role of ONX 0914 in CV infection, we conclude that the efficacy of ip inhibitors for CV-triggered myocarditis in A/J mice relies on their immunomodulatory effects on the systemic inflammatory reaction.
Fixation stability and implant-associated complications in periacetabular osteotomy: a comparison of screw and K-wire fixation
Creators: name: Leopold, Vincent Justus
name: Conrad, Juana
name: Zahn, Robert Karl
name: Hipfl, Christian
name: Perka, Carsten
name: Hardt, Sebastian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Developmental dysplasia of the hip
subject: Periacetabular osteotomy
subject: Surgical technique
subject: Fixation options
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aims: The aim of this study was to compare the fixation stability and complications in patients undergoing periacetabular osteotomy (PAO) with either K-wire or screw fixation. Patients and methods: We performed a retrospective study to analyze a consecutive series of patients who underwent PAO with either screw or K-wire fixation. Patients who were treated for acetabular retroversion or had previous surgery on the ipsilateral hip joint were excluded. 172 patients (191 hips: 99 K-wire/92 screw fixation) were included. The mean age at the time of PAO was 29.3 years (16-48) in the K-wire group and 27.3 (15-45) in the screw group and 83.9% were female. Clinical parameters including duration of surgery, minor complications (soft tissue irritation and implant migration) and major complications (implant failure and non-union) were evaluated. Radiological parameters including LCE, TA and FHEI were measured preoperatively, postoperatively and at 3-months follow-up. Results: Duration of surgery was significantly reduced in the K-wire group with 88.2 min (53-202) compared to the screw group with 119.7 min (50-261) (p < 0.001). Soft tissue irritation occurred significantly more often in the K-wire group (72/99) than in the screw group (36/92) (p < 0.001). No group showed significantly more implant migration than the other. No major complications were observed in either group. Postoperative LCE, TA and FHEI were improved significantly in both groups for all parameters (p = < 0.0001). There was no significant difference for initial or final correction for the respective parameters between the two groups. Furthermore, no significant difference in loss of correction was observed between the two groups for the respective parameters. Conclusion: K-wire fixation is a viable and safe option for fragment fixation in PAO with similar stability and complication rates as screw fixation. An advantage of the method is the significantly reduced operative time. A disadvantage is the significantly higher rate of implant-associated soft tissue irritation, necessitating implant removal.
Triple‐Osteotomy leads to substantially improved quality of life in patients with hip dysplasia
Creators: name: Lenz, Julia Elisabeth
name: Riedl, Moritz
name: Szymski, Dominik
name: Landgraeber, Stefan
name: Alt, Volker
name: Fickert, Stefan
Publisher: name: Universität Regensburg
Year: 2025
Subjects: subject: Germany, hip, iHOT33, quality of life, triple
subject: 610 Medizin

description: Purpose
Triple-Osteotomy (TO) is a hip-preserving surgical technique designed to correct symptomatic hip dysplasia by achieving three-dimensional acetabular reorientation and improving femoral head coverage. This procedure has shown promising outcomes in pain reduction, functional recovery, and quality of life, particularly in young, active patients. While periacetabular-osteotomy (PAO) is another well-established method for hip preservation, the specific advantages of TO, especially in early recovery and patient-reported outcomes (PROMs), remain underexplored. This study evaluates the mid-term outcomes of TO using the iHOT33 tool to provide a comprehensive understanding of its clinical benefits.
Methods
This non-randomised, retrospective registry study within the German Cartilage Registry included 48 patients with symptomatic, radiologically confirmed hip dysplasia who underwent TO by the same specialist. The follow-up rate at 24 months was 60.4% with a mean follow-up time of 24 months. Outcomes measured included iHOT33 scores, quality of life, VAS for pain, satisfaction, perceived treatment benefit, and unemployment rate. Paired t-tests and regression analysis (p < 0.05) were applied.
Results
Preoperative iHOT33 scores averaged 46.9, increasing to 70.8 after 24 months (Δ 23.9), with notable improvement in the first 6 months (Δ 15.8). The “social” subdomain showed the greatest improvements (Δ 30 points), alongside improvements in quality of life and pain reduction (VAS). Postoperative angles (VCE 31° ± 4°, acetabular index 0° ± 3°) were within the normal range. No significant correlation was found between angle changes and iHOT33 scores, indicating benefits across dysplasia severities.
Conclusions
Triple-osteotomy offers significant and rapid improvements in patient-reported outcomes for individuals with hip dysplasia, particularly in enhancing social and sports-related quality of life as measured by iHOT33 and other subjective assessments. Its potential advantages over Periacetabular-osteotomy, especially in terms of early recovery, warrant further investigation through prospective, comparative studies to better define its role in hip-preserving surgical strategies.
Provenienzforschung x Maschinelles Lernen. Über Anwendungsmöglichkeiten, Potentiale und Herausforderungen
Creators: name: Lang, Sabine
Publisher: name: Zenodo
Year: 2025
Subjects: Provenienzforschung
Machine Learning
Universitätssammlungen

description: Präsentationsfolien zum Vortrag von Sabine Lang (FAU Erlangen-Nürnberg) beim SODa Forum am 10. April 2025 zum Thema "Machine Learning und Provenienzforschung". Link zur Veranstaltung: https://sammlungen.io/archive/machine-learning-und-provenienzforschung
Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro–in vivo extrapolation
Creators: name: Algharably, Engi Abd El-Hady
name: Di Consiglio, Emma
name: Testai, Emanuela
name: Kreutz, Reinhold
name: Gundert-Remy, Ursula
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Animal alternative
subject: Dose–response modeling
subject: In silico
subject: Neurotoxicity
subject: Physiologically based pharmacokinetic modeling
subject: Reverse dosimetry
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system, among others. We applied physiologically based pharmacokinetic (PBPK) modeling combined with benchmark dose modeling to predict, based on published in vitro data, the in vivo dose of amiodarone which may lead to adverse neurological effects in patients. We performed in vitro-in vivo extrapolation (IVIVE) from concentrations measured in the cell lysate of a rat brain 3D cell model using a validated human PBPK model. Among the observed in vitro effects, inhibition of choline acetyl transferase (ChAT) was selected as a marker for neurotoxicity. By reverse dosimetry, we transformed the in vitro concentration-effect relationship into in vivo effective human doses, using the calculated in vitro area under the curve (AUC) of amiodarone as the pharmacokinetic metric. The upper benchmark dose (BMDU) was calculated and compared with clinical doses eliciting neurological adverse effects in patients. The AUCs in the in vitro brain cell culture after 14-day repeated dosing of nominal concentration equal to 1.25 and 2.5 mu M amiodarone were 1.00 and 1.99 mu g*h/mL, respectively. The BMDU was 385.4 mg for intravenous converted to 593 mg for oral application using the bioavailability factor of 0.65 as reported in the literature. The predicted dose compares well with neurotoxic doses in patients supporting the hypothesis that impaired ChAT activity may be related to the molecular/cellular mechanisms of amiodarone neurotoxicity. Our study shows that predicting effects from in vitro data together with IVIVE can be used at the initial stage for the evaluation of potential adverse drug reactions and safety assessment in humans.
Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women
Creators: name: Schultebraucks, Katharina
name: Maslahati, Tolou
name: Wingenfeld, Katja
name: Hellmann-Regen, Julian
name: Kraft, Julia
name: Kownatzki, Maureen
name: Behnia, Behnoush
name: Ripke, Stephan
name: Otte, Christian
name: Roepke, Stefan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: oxytocin
subject: trauma-associated memories
subject: Intranasal oxytocin administration
subject: post-traumatic stress disorder (PTSD)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Intrusive memories are a hallmark symptom of post-traumatic stress disorder (PTSD) and oxytocin has been implicated in the formation of intrusive memories. This study investigates how oxytocin influences the acquisition and consolidation of trauma-associated memories and whether these effects are influenced by individual neurobiological and genetic differences. In this randomized, double-blind, placebo-controlled study, 220 healthy women received either a single dose of intranasal 24IU oxytocin or a placebo before exposure to a trauma film paradigm that solicits intrusive memories. We used a "general random forest" machine learning approach to examine whether differences in the noradrenergic and hypothalamic-pituitary-adrenal axis activity, polygenic risk for psychiatric disorders, and genetic polymorphism of the oxytocin receptor influence the effect of oxytocin on the acquisition and consolidation of intrusive memories. Oxytocin induced significantly more intrusive memories than placebo did (t(188.33) = 2.12, p = 0.035, Cohen's d = 0.30, 95% CI 0.16-0.44). As hypothesized, we found that the effect of oxytocin on intrusive memories was influenced by biological covariates, such as salivary cortisol, heart rate variability, and PTSD polygenic risk scores. The five factors that were most relevant to the oxytocin effect on intrusive memories were included in a Poisson regression, which showed that, besides oxytocin administration, higher polygenic loadings for PTSD and major depressive disorder were directly associated with a higher number of reported intrusions after exposure to the trauma film stressor. These results suggest that intranasal oxytocin amplifies the acquisition and consolidation of intrusive memories and that this effect is modulated by neurobiological and genetic factors. Trial registration: NCT03031405.