Additional file 1 of Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men
Creators: name: Nakagawa-Nagahama, Yoshiko
name: Igarashi, Masaki
name: Miura, Masaomi
name: Kashiwabara, Kosuke
name: Yaku, Keisuke
name: Fukamizu, Yuichiro
name: Sato, Toshiya
name: Sakurai, Takanobu
name: Nakagawa, Takashi
name: Kadowaki, Takashi
name: Yamauchi, Toshimasa
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: Supplementary Table 1. The correlations between age and the level of NAD+ related metabolites. The correlation between age (year) and NAD+ related metabolites (μM). Comparisons were made using the Spearman’s rank correlation coefficient. The correlation coefficients and p-values analyzed excluding outliers are presented in parentheses. Supplementary Table 2. The correlation between the level of NAD+ and hearing thresholds at each frequency. The correlation between the level of NAD+ (μM) and right or left-ear hearing thresholds at each frequency (dB HL). Comparisons were made using the Spearman’s rank correlation coefficient. The correlation coefficients and p-values analyzed excluding outliers are presented in parentheses. Supplementary Table 3. The correlation between the level of NAMN and hearing thresholds at each frequency. The correlation between the level of NAMN (μM) and right or left-ear hearing thresholds at each frequency (dB HL). Comparisons were made using the Spearman’s rank correlation coefficient. The correlation coefficients and p-values analyzed excluding outliers are presented in parentheses. Supplementary Table 4. The correlation between the level of NMN and hearing thresholds at each frequency. The correlation between the level of NMN (μM) and right or left-ear hearing thresholds at each frequency (dB HL). Comparisons were made using the Spearman’s rank correlation coefficient. The correlation coefficients and p-values analyzed excluding outliers ae presented in parentheses. Supplementary Table 5. The correlation between the level of NR and hearing thresholds at each frequency. The correlation between the level of NR (μM) and right or left-ear hearing thresholds at each frequency (dB HL). Comparisons were made using the Spearman’s rank correlation coefficient. The correlation coefficients and p-values analyzed excluding outliers are presented in parentheses. Supplemental Figure 1. The correlation between the level of NAR and hearing thresholds at each frequency. (A) The correlation between the level of NAR (μM) and right or left-ear hearing thresholds at each frequency (dB HL). (B) The correlation between the level of NAR and right-ear hearing thresholds at 250Hz. (C and D) The correlation between the level of NAR and left-ear hearing thresholds at 1000Hz(C) and 2000Hz(D). Comparisons were made using the Spearman’s rank correlation coefficient. The correlation coefficients and p-values analyzed excluding outliers are presented in parentheses. *P &lt; 0.05; **P &lt; 0.01