cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gyrokinetic Equations for Strong-Gradient Regions
Creators: name: Dimits, Andris M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: A gyrokinetic theory is developed under a set of orderings applicable to the edge region of tokamaks and other magnetic confinement devices, as well as to internal transport barriers. The result is a practical set equations that is valid for large perturbation amplitudes [qδψ/T = O(1), where δψ = δϕ - v_par δA_par/c], which is straightforward to implement numerically, and which has straightforward expressions for its conservation properties. Here, q is the particle charge, δϕ and δA_par are the perturbed electrostatic and parallel magnetic potentials, v_par is the parallel velocity, c is the speed of light, and T is the temperature. The derivation is based on the quantity ε:=(ρ/λ)qδψ/T << 1 as the small expansion parameter, where ρ is the gyroradius and λ is the perpendicular wavelength. Physically, this ordering requires that the E\times B velocity and the component of the parallel velocity perpendicular to the equilibrium magnetic field are small compared to the thermal velocity. For nonlinear fluctuations saturated at "mixing-length" levels (i.e., at a level such that driving gradients in profile quantities are locally flattened), ε is of order ρ/L, where L is the equilibrium profile scale length, for all scales λ ranging from ρ to L. This is true even though qδψ/T = O(1) for λ ~ L. Significant additional simplifications result from ordering L/R =O(ε), where R is the spatial scale of variation of the magnetic field. We argue that these orderings are well satisfied in strong-gradient regions, such as edge and screapeoff layer regions and internal transport barriers in tokamaks, and anticipate that our equations will be useful as a basis for simulation models for these regions.
description: Accepted for publication in the Physics of Plasmas, 12/30/2011
Thermally activated conductivity in gapped bilayer graphene
Creators: name: Trushin, Maxim
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: This is a theoretical study of electron transport in gated bilayer graphene - a novel semiconducting material with a tunable band gap. It is shown that the which-layer pseudospin coherence enhances the subgap conductivity and facilitates the thermally activated transport. The mechanism proposed can also lead to the non-monotonic conductivity vs. temperature dependence at a band gap size of the order of 10 meV. The effect can be observed in gapped bilayer graphene sandwiched in boron nitride where the electron-hole puddles and flexural phonons are strongly suppressed.
description: 6 pages, 6 figures, revised, as published in EPL. To be displayed within Graphene Week 2012 Poster Session I
Tacsac A Wearable Haptic Device with Capacitive Touch-Sensing Capability for Tactile Display
Creators: name: Wahlbom, Anders
name: Dahiya, Ravinder
Publisher: name: figshare
Year: 2021
Subjects: subject: 170112 Sensory Processes, Perception and Performance
subject: FOS: Psychology

description: Published article: Tacsac A Wearable Haptic Device with Capacitive Touch-Sensing Capability for Tactile Display
Like a Carsic River: Gay Independent Cinema from Underground Films to New Queer Cinema and Beyond
Creators: name: Grassi, Silvia
Publisher: name: Università degli  Studi di Milano
Year: 2009

description: Like a Carsic River: Gay Independent Cinema from Underground Films to New Queer Cinema and Beyond.
description: Altre Modernità, No 2 (2009): Letterature e migrazioni
A dynamical analysis of the Kepler-11 planetary system
Creators: name: Migaszewski, Cezary
name: Slonina, Mariusz
name: Gozdziewski, Krzysztof
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Kepler-11 star hosts at least six transiting super-Earth planets detected through the precise photometric observations of the Kepler mission (Lissauer et al.). In this paper, we re-analyze the available Kepler data, using the direct N-body approach rather than an indirect TTV method in the discovery paper. The orbital modeling in the realm of the direct approach relies on the whole data set, not only on the mid-transits times. Most of the results in the original paper are confirmed and extended. We constrained the mass of the outermost planet g to less than 30 Earth masses. The mutual inclinations between orbits b and c as well as between orbits d and e are determined with a good precision, in the range of [1,5] degrees. Having several solutions to four qualitative orbital models of the Kepler-11 system, we analyze its global dynamics with the help of dynamical maps. They reveal a sophisticated structure of the phase space, with narrow regions of regular motion. The dynamics are governed by a dense net of three- and four-body mean motion resonances, forming the Arnold web. Overlapping of these resonances is a main source of instability. We found that the Kepler-11 system may be long-term stable only in particular multiple resonant configurations with small relative inclinations. The mass-radius data derived for all companions reveal a clear anti-correlation between the mean density of the planets with their distance from the star. This may reflect the formation and early evolution history of the system.
description: 21 pages, 19 figures, 9 tables, accepted to MNRAS
Investigating the Role of Maternal Microbiota and Antibodies in Development of the Neonatal Immune System
Creators: name: Czyz, Sonia
Publisher: name: Graduate Studies
Year: 2023
Subjects: subject: Neonate
subject: Maternal microbiome
subject: Immune system
subject: Early-life development
subject: Innate lymphoid cells
subject: Intestinal monomuclear cells
subject: Microbiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Microbial colonization in early life plays a critical role in the development and education of the host’s immune system. However, the precise mechanisms underlying microbial-immune interactions during the early life period are still under investigated. Postnatal colonization of the body with microbes was assumed to be the main stimulus for neonatal immune development. However, our group previously demonstrated that the maternal microbiota during gestation shapes the immune system of the offspring, both in utero and postnatally. This thesis aims to examine the underlying mechanisms by which the maternal microbiota drives neonatal immune development and the functional consequence of the maternal microbiota on offspring resistance to systemic infection. To disassociate the effects of the maternal microbiota from microbial signals coming from colonization after birth, a model of ‘gestational-only colonization’ was utilized. Firstly, the neonatal Fc receptor (FcRn) was found to be required for gestational-only colonization to induce ILC3 populations in the neonatal gut. Mechanistically, this suggests that the FcRn is necessary for transportation of maternal IgG-bound microbial products and metabolites to the offspring. Secondly, transfer of maternal anti-E. coli IgG induced ILC3 populations in the neonate, even when it was associated with products and metabolites generated by another bacterial species. This suggests that bacterial molecules may bind IgG in a non-specific manner and that this is sufficient to transfer the associated molecules to induce offspring immune cell changes. Lastly, we found gestational-only colonization led to reduced bacterial load in multiple offspring systemic organs after intravenous challenge with the pathogen S. aureus. Despite this, gestational-only colonization was not sufficient to protect the neonate from bacterial sepsis. Overall, this thesis revealed how maternal microbial products and metabolites are handled at the maternal-offspring interface in early life to educate the neonatal immune system and impact health outcomes in systemic infection.
Higgs portal, fermionic dark matter, and a Standard Model like Higgs at 125 GeV
Creators: name: Lopez-Honorez, Laura
name: Schwetz, Thomas
name: Zupan, Jure
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that fermionic dark matter (DM) which communicates with the Standard Model (SM) via the Higgs portal is a viable scenario, even if a SM-like Higgs is found at around 125 GeV. Using effective field theory we show that for DM with a mass in the range from about 60 GeV to 2 TeV the Higgs portal needs to be parity violating in order to be in agreement with direct detection searches. For parity conserving interactions we identify two distinct options that remain viable: a resonant Higgs portal, and an indirect Higgs portal. We illustrate both possibilities using a simple renormalizable toy model.
description: 16 pages, 4 figures; references and discussion of Sommerfeld effect added; matches published version
Homosexuality, AIDS and Representation in Jarman's Modern Nature and Smiling in Slow Motion
Creators: name: Parenza, Federica
Publisher: name: Università degli  Studi di Milano
Year: 2009

description: Homosexuality, AIDS and Representation in Jarman's Modern Nature and Smiling in Slow Motion
description: Altre Modernità, No 2 (2009): Letterature e migrazioni
Microbial Dynamics and Metabolism in Gnotobiotic Mouse Models of Autism Spectrum Disorder
Creators: name: Yee, Jenine R.
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: Autism Spectrum Disorder
subject: Maternal Immune Activation
subject: Metabolomics
subject: Gut microbiome
subject: Clostridium innocuum
subject: Health Sciences--Human Development
subject: Health Sciences--General
subject: Health Sciences--Immunology
subject: Developmental

description: Autism Spectrum Disorder (ASD) is a highly heterogeneous disorder with diagnoses based on core behaviours centering on limited social interest, anxiety, and obsessive and repetitive movements. Recent studies have revealed a potential link between composition of the gut microbiota and ASD. The bacterial species Clostridium innocuum was found to be highly abundant in children with ASD and significantly reduced following fecal microbiota transplantation. The maternal immune activation (MIA) model was chosen as an experimental model to investigate whether C. innocuum would alter susceptibility to ASD. As the MIA model has been shown to require segmented filamentous bacterium (SFB) induction of Interleukin 17 (IL-17) during pregnancy, a co-colonization system was required. In this thesis, we investigated the dynamics between SFB and two different strains of C. innocuum, one isolated from an ASD participant and the other isolated from a healthy donor. In this mouse model, SFB co-colonized similarly with either strain of C. innocuum. To further investigate the effect presence of the two C. innocuum strains, serum metabolite profiles were analyzed using liquid chromatography-mass spectrometry for semi-untargeted metabolomics. Although serum samples from mice co-colonized with SFB and either of the two C. innocuum strains had similar metabolite profiles, significantly different metabolomic profiles were found following induction of maternal immune activation. Aspartate, hippurate and glycerol-3-phosphate were found to be significantly upregulated in the mice co-colonized with the C. innocuum isolated from an ASD participant when MIA was induced. These metabolites have been found in altered levels in children with ASD and ASD mouse models. Finally, in vitro cultures of other bacterial species found post-FMT produced metabolites involved with cellular repair, energy production and antioxidant activity such as N-acetyl-L-cysteine, glutathione, inosine and glutamine compared to media controls. Metabolites produced by the C. innocuum from the ASD participant may potentiate ASD behaviours and unravel targets for future research.
Rhinovirus Modulation of Epithelial Barrier Function: Implicaitons for Metabolic and Cytoskeletal Pathways
Creators: name: Michi, Aubrey N
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: rhinovirus
subject: epithelial cell
subject: infection
subject: metabolism
subject: cytoskeleton
subject: Health Sciences--Immunology
subject: Biology--Cell
subject: Biology--Physiology

description: Human rhinoviruses have been identified as the primary etiologic agent of the common cold since the 1950s, yet over 65 years later there is no cure for rhinovirus infections. Rhinoviruses are extremely well adapted respiratory viruses that establish infections without causing overt cytotoxicity to their natural host cells, airway epithelial cells, which undergo extensive phenotypic changes during infection. These changes range from viral recognition to release of host defense molecules to physical changes in epithelial cytoskeletal architecture. As a mucosal surface, the airway epithelium primarily serves to maintain a tight epithelial barrier and perform immunosurveillance for invading pathogens. Therefore, the majority of our understanding of HRV infections focuses on host defense molecule regulation, and innate viral-specific host defense responses. However, our understanding of airway epithelial host defense remains incomplete, particularly the mechanisms by which the airway epithelium maintains both barrier function and metabolic processes during bioenergetically demanding events such as rhinovirus infections. In this work, we use a physiologically relevant in vitro modeling system, air-liquid interface (ALI) cultures of highly differentiated human bronchial epithelial cells, to effectively model rhinovirus-epithelial interactions to investigate two understudied epithelial functions during infection: epithelial barrier function and metabolism. There is a spectrum of barrier loss severity that occurs during rhinovirus infection and early-onset paracellular permeability is marked by changing cytoskeletal signaling pathways regulating actin stabilization and contractile mechanisms associated with tight junction integrity. Metabolomics and proteomics revealed that changing cell metabolism was a prominent feature of rhinovirus infections and allowed for the identification of a master regulator of cellular bioenergetics, peroxisome proliferator-activated receptor-gamma coactivator 1a (PGC-1a), as not only a metabolic regulator, but regulator of airway epithelial barrier function. Pharmacological promotion of PGC-1a resulted in restoration of rhinovirus-induced barrier loss, reduction in viral replication, and enhancement of antiviral host defenses. PGC-1a was further implicated in interacting with low energy sensing signaling pathways to promote enhanced interferon and antiviral host defenses during rhinovirus infection. This investigation strives to form a more unifying understanding of airway epithelial host defense responses of barrier function, metabolism, and antiviral responses to rhinovirus infections.
Tailoring Nanoparticle Designs for Cleaning up Oil Sands Process-affected Water
Creators: name: Hethnawi, Afif J.
Publisher: name: Schulich School of Engineering
Year: 2021
Subjects: subject: Environmental Sciences

description: Oil sands industry in Canada continuously produces enormous volume of toxic and low-quality oil sands process-affected water (OSPW) as a result of bitumen extraction, upgrading, and transportation. Typically, OSPW are treated by several chemical treatment stages that primarily focus on water recycling at high capital and operating costs with high environmental footprints. In this study, naturally sourced nanoparticles were designed for cleaning up OSPW through effective and combined process. Thus, nanoparticles with tunable properties were developed to generate hybrid filter media, nanoflocculants, and oil spill nanoscavengers. For the case of steam assisted gravity drainage (SAGD) produced water, under ambient conditions, hybrid filter media were manufactured via integrating low percentage (< 5 wt%) of iron hydroxide nanoparticles with walnut shell filter media (WS), in which the iron hydroxide nanoparticles elevated the active surface area for simultaneous removal of total organic carbon (TOC) and silica. For the tailing water, titanomagnetite nanoparticles, naturally known as ironsand, were synthesized uner ambient conditions and grafted with hydrophobically modified polyacrylamide with lauryl sulfate, forming novel nanoflocculant that was applied to flocculate the mature fine tailings (MFT). Furthermore, the bare titanomagnetite nanoparticles were employed for removal of crude oil spills, following our modified ASTM protocol. The results showed that the hybrid filtration media (WS-NPs) removed up to 85% of silica and TOC through the batch experiments. In the column tests WS-NPs significantly improved the breakthrough behavior without reaching pressure drop limitations. The column breakthrough behaviors were successfully described by a dimensionless advection-axial dispersion model, that was able to accurately capture the real breakthrough behavior, indicating the possibility of scaling up the filter using a combined unit that removes silica and TOC simultaneously. Also, flocculation of the MFT suspension with applying 3000 ppm of the optimized nanoflocculants, against 20,000 ppm of commercially anionic polyacrylamide, provided 15 times faster initial settling rate (ISR) and half values of supernatant turbidity, capillary suction time (CST), and specific resistance to filtration (SRF). Interestingly, a gram of our inhouse prepared iron sand nanoparticles removed 38g crude oil, showing outstanding performance toward oil spill removal.
Under British Eyes: The Complex Fortune of Italian Crime Fiction
Creators: name: Vallorani, Nicoletta
Publisher: name: Università degli  Studi di Milano
Year: 2010

description: Under British Eyes: The Complex Fortune of Italian Crime Fiction
(Mirna Cicioni & Nicoletta Di Ciolla (eds), Differences, Deceits and Desires. Murder and Mayhem in Italian Crime Fiction, Newark: University of Delaware Press, 2008, 228 p., ISBN 978-0-87413-051-5)
by Nicoletta Vallorani
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
A conjecture concerning determinism, reduction, and measurement in quantum mechanics
Creators: name: Jabs, Arthur
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences
subject: J.2

description: Determinism is established in quantum mechanics by tracing the probabilities in the Born rules back to the absolute (overall) phase constants of the wave functions and recognizing these phase constants as pseudorandom numbers. The reduction process (collapse) is independent of measurement. It occurs when two wavepackets overlap in ordinary space and satisfy a certain criterion, which depends on the phase constants of both wavepackets. Reduction means contraction of the wavepackets to the place of overlap. The measurement apparatus fans out the incoming wavepacket into spatially separated eigenpackets of the chosen observable. When one of these eigenpackets together with a wavepacket located in the apparatus satisfy the criterion, the reduction associates the place of contraction with an eigenvalue of the observable. The theory is nonlocal and contextual.
description: Latex, 21 pages, 1 figure, improvements at several places, reference added
Polycystic Ovarian Syndrome: An Investigation of Non-Pharmacologic Management Strategies and Cardiometabolic Consequences
Creators: name: Benham, Jamie L.
Publisher: name: Cumming School of Medicine
Year: 2021
Subjects: subject: Polycystic Ovary Syndrome
subject: Randomized Controlled Trial
subject: Exercise
subject: High-Intensity Interval Training
subject: Ovulation
subject: Ovulation Prediction
subject: Women’s Health
subject: Health Sciences--Medicine and Surgery

description: Background: Preliminary evidence suggests exercise training may result in improved reproductive, anthropometric, cardiometabolic and psychosocial health in women with polycystic ovary syndrome (PCOS).Objective: To evaluate the effects of exercise training on reproductive, anthropometric, cardiometabolic, and sleep quality health measures in reproductive-aged women with PCOS.Methods: First, we performed a systematic review and meta-analysis of studies assessing the effects of exercise training on reproductive outcomes. Second, we performed a pilot randomized controlled trial evaluating the feasibility of conducting a larger trial evaluating reproductive, anthropometric, cardiometabolic, and sleep quality health measures. Feasibility outcomes included: participant recruitment, attrition, adherence to prescribed exercise and daily ovulation assessment.Results: The systematic review included 14 studies involving 617 women. Semi-quantitative analysis suggested exercise training may increase ovulation rates, menstrual regularity and pregnancy. In the trial, all recruitment methods were important as each recruited participant was not reached by the other methods. 47 participants were randomized: no-exercise control (n=17), high-intensity interval training (HIIT) (n=16), continuous aerobic exercise training (CAET) (n=14). Across all groups, attrition was 15%. Median exercise adherence was 68% (IQR 53%, 86%). Ovulation assessment adherence dropped from 87% (IQR 61%, 97%) in the first 3-months of the intervention to 65% (IQR 0%, 96%) in the final 3-months. 22/33 (66.7%) women ovulated during the intervention period with no between-group differences. Body mass index decreased for CAET compared with HIIT (-0.9 kg/m2, p=0.04) and control (-1.0 kg/m2, p=0.01). Mean waist circumference decreased significantly (-7.3 cm, -6.9 cm, -4.5 cm in HIIT, CAET and control) with no significant between-group differences. In HIIT compared with CAET, LDL-C decreased significantly (-0.33 mmol/L, p=0.03). In HIIT compared with control, HDL-C increased (0.18 mmol/L, p=0.04). 79% of participants reported poor sleep quality.Conclusions: While exercise training may improve anthropometric, reproductive and sleep quality health markers in women with PCOS, the effects of exercise training on reproductive health measures remain unclear. Feasibility challenges with exercise training and daily ovulation assessment adherence limited the ability to analyze the effect of exercise on ovulation. Further studies are needed to determine optimal exercise prescriptions for this population.
Il Golem in Moon Boots: storie americane al tempo di Obama
Creators: name: Vallorani, Nicoletta
Publisher: name: Università degli  Studi di Milano
Year: 2010

description: Il Golem in Moon Boots: storie americane al tempo di Obama
(Marco Sioli, American Golem. Lo spazio e il tempo degli Stati Uniti, Como - Pavia, Ibis, 2001, 2009, pp.251, ISBN978-88-7164-301-4)
di Nicoletta Vallorani
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
Il Gesù di Stracci
Creators: name: Vallorani, Nicoletta
Publisher: name: Università degli  Studi di Milano
Year: 2010

description: Il Gesù di Stracci
(Tomaso Subini, Pier Paolo Pasolini. La ricotta, Torino, Lindau, 2009, pp.221, ISBN 978-88-7180-814-7)
di Nicoletta Vallorani
description: Altre Modernità, No 4 (2010): La morte e i suoi riti nella cultura contemporanea
Synergy between pro-inflammatory cytokines and glucocorticoid on TLR2 expression: Mechanisms and consequences in pulmonary epithelial cells
Creators: name: Bansal, Akanksha
Publisher: name: Cumming School of Medicine
Year: 2022
Subjects: subject: Glucocorticoids
subject: Lung inflammation
subject: Toll-like receptor 2
subject: Biological Sciences

description: Glucocorticoids are effective in controlling mild-to-moderate asthma due to their profound anti-inflammatory properties. Acting via the glucocorticoid receptor (GR), glucocorticoids repress the expression of numerous inflammatory genes to ultimately dampen airway inflammation. Prior dogma suggests that ligand-activated GR may interact directly with inflammatory transcription factors at target gene loci to downregulate gene expression. However, glucocorticoids also inactivate mitogen-activated protein kinase (MAPK) pathways to reduce the expression of numerous inflammatory genes. Despite this, the repression of inflammatory gene expression is not an invariable outcome of glucocorticoid action. In this thesis, synergy occurring between synthetic glucocorticoids and pro-inflammatory cytokines on the expression of toll-like receptor 2 (TLR2), and its consequences, is explored in pulmonary epithelial cells. Mechanistically, the transcription factors, NF-?B and GR, were revealed as necessary for inducing TLR2 expression by IL1B plus glucocorticoid. Similarly, STAT1, along with NF-?B and GR, was involved in the upregulation of TLR2 expression by IL1B plus IFNG plus glucocorticoid. Thus, functional interactions between GR and inflammatory transcription factors, such as, NF-?B and STAT, can cooperatively increase gene transcription. In addition, p38 MAPK was shown to negatively regulate IL1B-induced TLR2 expression. Thus, glucocorticoid inhibition of p38 activity releases this negative regulation to enhance TLR2 expression in the context of IL1B plus glucocorticoid. This represents a mechanism by which glucocorticoids maintain, even enhance, the expression of genes that are negatively regulated by MAPKs. Agonism of glucocorticoid plus cytokine-induced TLR2 in A549 cells revealed enhanced and sensitized interferon response factor 1 (IRF1)-dependent responses, maintained NF-?B-dependent responses, albeit to a lower extent, coupled with the release of multiple cytokines and chemokines. Thus, expression of TLR2 induced by inflammatory cytokines plus glucocorticoids results in pro-inflammatory effects and is predicted to promote inflammatory cell recruitment. Overall, the transcriptional regulation of TLR2 illustrates distinct mechanisms that allow differential regulation of inflammatory gene expression by glucocorticoids. While the ability of glucocorticoids to promote TLR2-mediated effects may be a part of normal host defense, such effects may be undesirable in conditions, such as severe asthma or during viral exacerbations. Such pro-inflammatory effects that are resultant from enhanced TLR2 expression may contribute to glucocorticoid insensitivity.
Ultrastructural changes and mitochondrial DNA content in the hepatocytes of individuals co-infected with HIV and Hepatitis C virus following HCV combination therapy
Creators: name: Hiebert, Hayley
Publisher: name: University of British Columbia
Year: 2013

description: Background and objectives: Hepatitis C Virus (HCV) affects approximately 170 million people worldwide. Some estimates suggest up to 30% of these individuals are also infected with Human Immunodeficiency Virus (HIV). In Vancouver, British Columbia, the percent of HIV/HCV co-infected individuals is even greater, approaching 50% of those infected with HIV. Since the advent of highly active anti-retroviral therapy (HAART), the leading cause of death for HIV positive individuals is end stage liver disease often associated with chronic HCV infection. Previous work by our laboratory did not provide evidence of significant hepatocellular or mitochondrial toxicity associated with HAART treatment. Since it is suggested that drugs used in both HAART and HCV combination therapy may be toxic to the liver, the concurrent use of these treatments in co-infected individuals may be associated with increased hepatocellular and mitochondrial toxicity. The objective of this study was to determine the ultrastructural and mitochondrial DNA content changes that occur in liver hepatocytes in response to HCV combination therapy in co-infected individuals. Hypothesis: HCV combination therapy is associated with ultrastructural hepatocellular changes consistent with either damage or tissue repair in HIV and HCV co-infected patients. Methods: Liver biopsies were taken from co-infected patients before and after receiving HCV combination therapy. One biopsy was used for pathology assessment, the other was divided for nucleic acid assays and transmission electron microscopy (TEM). TEM samples were then examined for ultrastructural changes in hepatocytes following HCV combination therapy. Results: Biopsies from 11 subjects were collected. Of the subjects examined, liver pathology improved significantly following HCV combination therapy while no differences were observed in the mtDNA to nDNA ratio before and after treatment. Ultrastructural analysis of hepatocytes revealed a significant decrease in lipid content following HCV combination therapy. Conclusions: Overall, these results suggest that HCV combination therapy is beneficial to liver health and lessens liver pathology in HIV/HCV co-infected patients featuring a reduction in lipid content or steatosis. Future studies involving greater sample size are required to determine additional effects of HCV combination therapy on co-infected individuals.
Additional file 1 of LIQA: long-read isoform quantification and analysis
Creators: name: Hu, Yu
name: Fang, Li
name: Chen, Xuelian
name: Zhong, Jiang F.
name: Li, Mingyao
name: Wang, Kai
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Figures S1-S13 and Tables S1-S7.
AlN Ultra-Thin Chips Based Flexible Piezoelectric Tactile Sensor
Creators: name: Wahlbom, Anders
name: Dahiya, Ravinder
Publisher: name: figshare
Year: 2021
Subjects: subject: 170112 Sensory Processes, Perception and Performance
subject: FOS: Psychology

description: Conference paper: AlN Ultra-Thin Chips Based Flexible Piezoelectric Tactile Sensor
On the mass radiated by coalescing black-hole binaries
Creators: name: Barausse, Enrico
name: Morozova, Viktoriya
name: Rezzolla, Luciano
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We derive an analytic phenomenological expression that predicts the final mass of the black-hole remnant resulting from the merger of a generic binary system of black holes on quasi-circular orbits. Besides recovering the correct test-particle limit for extreme mass-ratio binaries, our formula reproduces well the results of all the numerical-relativity simulations published so far, both when applied at separations of a few gravitational radii, and when applied at separations of tens of thousands of gravitational radii. These validations make our formula a useful tool in a variety of contexts ranging from gravitational-wave physics to cosmology. As representative examples, we first illustrate how it can be used to decrease the phase error of the effective-one-body waveforms during the ringdown phase. Second, we show that, when combined with the recently computed self-force correction to the binding energy of nonspinning black-hole binaries, it provides an estimate of the energy emitted during the merger and ringdown. Finally, we use it to calculate the energy radiated in gravitational waves by massive black-hole binaries as a function of redshift, using different models for the seeds of the black-hole population.
description: 9 pages (emulateapj), 4 figures. Matches version in ApJ but includes slight changes to fig 4 described in Barausse, et al ApJ 786, 76 (2014) (doi:10.1088/0004-637X/786/1/76), see also http://www2.iap.fr/users/barausse/erratum_mass_formula.pdf
La “gravità” dei Settanta: reticolarità e dissidenza in Gravity’s Rainbow di Thomas Pynchon
Creators: name: Mansutti, Pamela
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Pynchon; Gravity’s Rainbow; paranoia; cospirazione; reticolarità

description: Uno dei cambiamenti radicali avvenuti negli anni Settanta in ambito statunitense riguarda il concetto di soggettività e la sua relazione con i sistemi politici, mediatici ed economici impegnati a produrla e controllarla. La deriva della controcultura in frange estremiste e la svolta conservatrice imposta dalla presidenza Nixon impongono un clima paranoico e cospiratorio, in cui il soggetto critico si scopre ganglio di larghe strutture ramificate che aspira a distruggere poteri oppresivi sovraindividuali, siano essi statali, militari o informativi, ri-negoziando di volta in volta la propria identità come libera o antagonistica. Tuttavia spesso la “dissidenza” rispetto a queste strutture finisce per essere un gesto fatuo, letale, o addirittura irrealizzabile. Le possibilità e i limiti di questa autodeterminazione politico-culturale del soggetto sono variamente espressi dalla letteratura americana del decennio, in particolare da Gravity’s Rainbow (1973) di Thomas Pynchon, in cui il mondo travolto dalla Seconda Guerra Mondiale appare come una metafora della rete di trame eterogenee, concatenate e impercettibili amplificate dalla Guerra Fredda e sostenute dal potere tecnologico-informativo destinato ad esplodere negli anni Settanta. Pynchon sintetizza la complessità e l’ambivalenza del sistema culturale postmoderno, nel quale l’individuo, sadicamente manipolato, fatica a concepire spazi di libertà e ad organizzare forme collettive di resistenza.
description: ENTHYMEMA, No 7 (2012)
The Young Modulus of Black Strings and the Fine Structure of Blackfolds
Creators: name: Armas, Jay
name: Camps, Joan
name: Harmark, Troels
name: Obers, Niels A.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We explore corrections in the blackfold approach, which is a worldvolume theory capturing the dynamics of thin black branes. The corrections probe the fine structure of the branes, going beyond the approximation in which they are infinitely thin, and account for the dipole moment of worldvolume stress-energy as well as the internal spin degrees of freedom. We show that the dipole correction is induced elastically by bending a black brane. We argue that the long-wavelength linear response coefficient capturing this effect is a relativistic generalization of the Young modulus of elastic materials and we compute it analytically. Using this we draw predictions for black rings in dimensions greater than six. Furthermore, we employ our corrected blackfold equations to various multi-spinning black hole configurations in the blackfold limit, finding perfect agreement with known analytic solutions.
description: v1: 28 pages + appendices. v2: Important sign corrections in sec. 3. Other minor corrections
title: Urinary bladder goes to ER: a comprehensive and schematic approach to its anatomy and pathologies
Creators: name: Gonzalo Carballés, Marta
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Emergency
subject: Urinary Tract / Bladder
subject: Abdomen
subject: CT
subject: Ultrasound
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To provide a comprehensive review of the anatomical landmarks of urinary bladder. Toidentify common and uncommon emergent conditions of urinary bladder. To illustrate key radiological findings which may provide a correct...
Summability implies Collet-Eckmann almost surely
Creators: name: Gao, Bing
name: Shen, Weixiao
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We provide a strengthened version of the famous Jakobson's theorem. Consider an interval map $f$ satisfying a summability condition. For a generic one-parameter family $f_t$ of maps with $f_0=f$, we prove that $t=0$ is a Lebesgue density point of the set of parameters for which $f_t$ satisfies both the Collect-Eckmann condition and a strong polynomial recurrence condition.
description: 25 pages
Design and Evaluation of an Instrumented Equine Shoe for Kinetic Gait Analysis
Creators: name: Devolin, Alanna
Publisher: name: Schulich School of Engineering
Year: 2023
Subjects: subject: Instrumentation Design
subject: Kinetic Gait Analysis
subject: Objective Gait Analysis
subject: Embedded System Design
subject: Biomechanics
subject: Equine
subject: Horse
subject: Engineering--Biomedical
subject: Engineering--Electronics and Electrical
subject: Biology--Veterinary Science

description: Within the field of equine veterinary medicine, the diagnosis, prevention and treatment of lameness is one of the most challenging problems facing practitioners and horse owners. There is a clear need for a better understanding of the biomechanics of equine locomotion and objective methods of analyzing gait. There are a variety of biomechanical tools that are kinematic or kinetic based. Current methods of kinetic gait analysis include force plates, instrumented treadmills, and instrumented horseshoes. All these devices measure Ground Reaction Forces (GRFs). Force plates are considered the gold standard for kinetic gait analysis but are unable to record successive strides. The instrumented treadmill permits the measurement of successive strides, but measurement can only be performed on a treadmill. The instrumented horseshoe permits the measurement of successive strides on a variety of surfaces, but the technical challenges associated with the development have limited their use to research institutes and universities. The intention of this project is to conceptualize, design, and evaluate an instrumented horseshoe for the analysis of gait in horses. A prototype was developed after determining the design requirements, evaluating a force sensor, integrating the force sensor into the electrical design, developing software for data collection, and developing a mechanical assembly to house the electronics and transfer force to the sensors. Two prototypes were developed within the scope of this project. The first prototype was tested on the forelimb of a test horse and the data collected was evaluated with a post-test sensor characterization to determine the forces applied. The forces measured during the test on the horse were lower than expected. The second prototype was modified slightly, and an additional system was created to permit four self-contained devices to be synchronized in time to measure GRFs from the horse. Data were collected from all four devices. A mechanical failure prevented a proper evaluation of the forces, but temporal data were determined. The goal of future work is to develop a reliable and practical device for longitudinal monitoring of the equine gait to inform our understanding of equine locomotion, supplement lameness exams, and as an outcome measure for research studies.
title: Thyroid Doppler: Brief review of the method and proposed standardization of documentation
Creators: name: Francolin, Peter
Publisher: name: European Congress of Radiology
Year: 2019
Subjects: subject: Ear / Nose / Throat
subject: Head and neck
subject: Thyroid / Parathyroids
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Power Doppler
subject: Ultrasound-Spectral Doppler
subject: Diagnostic procedure
subject: Education
subject: Technical aspects
subject: Education and training
subject: Endocrine disorders
subject: Image registration

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the key findings related to ultrasoundof thyroid,showing the usefulness and importance of color and pulsed Doppler analisis in combination withB-mode in the evaluation of the thyroid gland. This paperdid not cover elastographyor discuss...
Asymptotic analysis of the stochastic block model for modular networks and its algorithmic applications
Creators: name: Decelle, Aurelien
name: Krzakala, Florent
name: Moore, Cristopher
name: Zdeborová, Lenka
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: In this paper we extend our previous work on the stochastic block model, a commonly used generative model for social and biological networks, and the problem of inferring functional groups or communities from the topology of the network. We use the cavity method of statistical physics to obtain an asymptotically exact analysis of the phase diagram. We describe in detail properties of the detectability/undetectability phase transition and the easy/hard phase transition for the community detection problem. Our analysis translates naturally into a belief propagation algorithm for inferring the group memberships of the nodes in an optimal way, i.e., that maximizes the overlap with the underlying group memberships, and learning the underlying parameters of the block model. Finally, we apply the algorithm to two examples of real-world networks and discuss its performance.
description: Typos in eq. (40) on p. 13 fixed
Cryogenic Noise-Parameter Measurement and the Design of Cryo-CMOS Circuits
Creators: name: Sheldon, Alexander W.
Publisher: name: Schulich School of Engineering
Year: 2022
Subjects: subject: Cryogenic
subject: Circuits
subject: Integrated Circuits
subject: Radio Astronomy
subject: Quantum Computing
subject: Noise Parameters
subject: Engineering--Electronics and Electrical

description: In this thesis, research into the application of cryogenic-CMOS (cryo-CMOS) circuits for radio astronomy and quantum computing are discussed. The thesis consists of three contributions to the field of CMOS circuit design and measurement:1) a fully-automated cryogenic noise-parameter measurement system,2) the design and verification of a radio-astronomy-grade cryo-CMOS low-noise amplifier (LNA) for the Dominion Radio Astrophysics Observatory (DRAO) synthesis telescope in Penticton, British Columbia, Canada, and3) a noise-matched low-power oscillator architecture for quantum computing applications.The three contributions are discussed in detail and unique problems associated with cryogenic design and measurement are discussed. The cryogenic noise-parameter measurement system enables the characterization of low-noise amplifiers for radio astronomy and quantum computing applications. The system iscapable of measuring noise parameters of LNAs at temperatures from 15K to 325K for frequencies up to 6 GHz and achieves a noise-temperature uncertainty of less than 1 K. The designed cryo-CMOS LNA operates at 20K over a frequency band of 0.9-to-1.8 GHz and achieves an average noise temperature of 5.4 K, an average gain of 37.2 dB, and an input return loss of better than 10 dB while consuming 115mW of power. This shows that CMOS can achieve comparable RF performance to exotic technologies at cryogenic temperatures. The designed oscillator topology uses LNA design procedures to break the trade off between power consumption and phase noise. The oscillator oscillates at 10.74GHz and achieves a 6 dB improvement in phase noise and figure of merit as compared to a traditional cross-coupled LC oscillator. The circuit consumes 980 ?W of power, and achieves a phase noise of -115.5 dBc/Hz at 1-MHz offset resulting in a figure of merit of 196.4 dBc/Hz. The research that makes up this thesis led to advancements that will enable the characterization of CMOS devices and circuits at cryogenic temperatures for RF applications. These advancements will create opportunities for the development of high sensitivity receivers.
Rage against the Machine: Vincenzo Agnetti’s Critique of Industrial Alienation
Creators: name: Moure Cecchini, Laura
Publisher: name: Università degli Studi di Milano
Year: 2012
Subjects: Estrangement, Industrial Design, Conceptual art, Zeroing

description: This essay analyzes the work of the Milanese artist Vincenzo Agnetti (1926-1981), in particular his pieces La macchina drogata (1968) and NEG (1970). Like other Italian artists and intellectuals of the 1960s and 1970s, Agnetti was concerned about the alienation caused by industrial development and consumer society, manifested in carefully designed objects of everyday use. To counteract the automatism of perception and thought that he considered the sign of alienated experience, Agnetti’s artworks employed several strategies that obliged the public to attend to its thinking processes. Thus, Agnetti put in practice forms of aesthetic estrangement similar to those evoked in the same period by Gillo Dorfles and Umberto Eco to counteract the widespread loss of awareness.
description: ENTHYMEMA, No 7 (2012)
Interpretation of the flares of M87 at TeV energies in the cloud-jet interaction scenario
Creators: name: Barkov, Maxim V.
name: Bosch-Ramon, Valenti
name: Aharonian, Felix A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Active galactic nuclei with misaligned jets have been recently established as a class of high-energy gamma-ray sources. M87, a nearby representative of this class, shows fast TeV variability on timescales less than one day. We present calculations performed in the framework of the scenario in which gamma-ray flares in non-blazar active galactic nuclei are produced by a red giant or a gas cloud interacting with the jet. We show that both the light curve and energy spectrum of the spectacular April 2010 flare can be reproduced by this model, assuming that a relatively massive cloud of approx 1.e29 g penetrates into the jet at few tens of Schwarzschild radii from the super-massive black hole.
description: 8 pages, 8 figures, accepted by ApJ