cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluating WAIS–IV structure through a different psychometric lens: structural causal model discovery as an alternative to confirmatory factor analysis
Creators: name: Dijk, Marjolein J. A. M. Van
name: Claassen, Tom
name: Christiany Suwartono
name: Veld, William M. Van Der
name: Heijden, Paul T. Van Der
name: Hendriks, Marc P. H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objective: Since the publication of the WAIS–IV in the U.S. in 2008, efforts have been made to explore the structural validity by applying factor analysis to various samples. This study aims to achieve a more fine-grained understanding of the structure of the Dutch language version of the WAIS–IV (WAIS–IV–NL) by applying an alternative analysis based on causal modeling in addition to confirmatory factor analysis (CFA). The Bayesian Constraint-based Causal Discovery (BCCD) algorithm learns underlying network structures directly from data and assesses more complex structures than is possible with factor analysis. Method: WAIS–IV–NL profiles of two clinical samples of 202 patients (i.e. patients with temporal lobe epilepsy and a mixed psychiatric outpatient group) were analyzed and contrasted with a matched control group (N = 202) selected from the Dutch standardization sample of the WAIS–IV–NL to investigate internal structure by means of CFA and BCCD. Results: With CFA, the four-factor structure as proposed by Wechsler demonstrates acceptable fit in all three subsamples. However, BCCD revealed three consistent clusters (verbal comprehension, visual processing, and processing speed) in all three subsamples. The combination of Arithmetic and Digit Span as a coherent working memory factor could not be verified, and Matrix Reasoning appeared to be isolated. Conclusions: With BCCD, some discrepancies from the proposed four-factor structure are exemplified. Furthermore, these results fit CHC theory of intelligence more clearly. Consistent clustering patterns indicate these results are robust. The structural causal discovery approach may be helpful in better interpreting existing tests, the development of new tests, and aid in diagnostic instruments.
Pew Research Center: American Trends Panel Wave 62
Creators: name: Pew Research Center
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: 2020 presidential election candidate news (3); President Donald Trump news (1); news coverage of political and social issues (8); understanding of Democratic presidential primary events (1); views of Democratic candidates (6); candidate support for "Medicare for all" (5); knowledge of openly gay/lesbian candidate (1); knowledge of self-identified democratic socialist candidate (1); knowledge of candidate who led creation of consumer financial protection bureau (1); knowledge of reason for delayed Iowa Democratic caucus results (1); Trump impeachment (5); reasons for Trump acquittal (5); foreign interference in 2016 US presidential election (2); presidential election news that seemed made-up (2); QAnon (1).
IN03112 Anuradhapura Pillar Inscription of the Reign of Dappula V
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03112
Epigraphia Zeylanica
Dappula V
Anuradhapura

description: IN03112 Anuradhapura Pillar Inscription of the Reign of Dappula V - Transcript and Translation Source: Paranavitana, S. (1928-33). ‘No. 8. A Fragmentary Inscription on a Pillar Discovered near the Jaffna Road, Anurādharpura (A. S. I., No. 92),’ Epigraphia Zeylanica 3, p. 128.
The UN Declaration on the Rights of Indigenous Peoples for Access to Justice, Redress, Restitution, and Non-recurrence Regarding Violation of Rights Affirmed in Treaties Between Indigenous Nations/States
Creators: Carmen, Andrea
Publisher: name: Columbia University
Year: 2014
Subjects: Indigenous peoples
Indians
Indians of North America
International law

description: In conclusion, the International Indian Treaty Council submitted the following recommendations: 1. That the EMRIP Study recognize, support and affirm the OAS Declaration Text Article XXIII, relevant CERD recommendations and other advances in the international arena affirming the rights in Treaties as understood and interpreted by Indigenous Peoples and advancing redress and access to justice in this regard. 2. That the EMRIP Study recommend that States and UN system implement bi-lateral, fully participatory processes for redress and restitution of rights affirmed in treaties, respecting their original spirit and intent as understood and interpreted by the Indigenous Peoples and utilizing the normative framework provided by the UN Declaration on the Rights of Peoples. 3. That the ERMIP Study recommend that the development of such effective, participatory international processes to resolve conflicts and redress violations related to Treaties and Agreements be included as focus for the 2014 World Conference on Indigenous Peoples
The universe or nothing: The heat death of the universe and it's ultimate fate
Creators: name: Aly, Islam Atef
Publisher: name: figshare
Year: 2017
Subjects: Cosmology

description:
This paper overviews my hypothesis of the ultimate fate of the universe, showing how it will reach the heat death, and how the dark energy has the main role in the universe movement and even it's end, this paper opens a new path in the searching about the nature of dark energy, by knowing that it's the reason why the universe is expanding, cooling and losing energy. And to note that in this paper we based on that the universe is closed.
Supplementary Material for: Liquid Biopsy: Value for Melanoma Therapy?
Creators: name: Buder-Bakhaya, K.
name: Machiraju, D.
name: Hassel, J.C.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Treatment of metastatic melanoma has undergone tremendous changes over the past few years. There are now highly effective systemic therapies available: targeted therapy with BRAF and MEK inhibitors in BRAF-V600-mutant melanoma and immunotherapies, including PD-1 antibodies with or without CTLA-4 antibody, that can be used regardless of mutational status. However, long-term tumor control is only achieved in a minority of patients. Liquid biopsy using circulating tumor cells, circulating tumor DNA (ctDNA), circulating mRNA and micro-RNA might represent valuable biomarkers, e.g. in the setting of systemic treatment for metastatic melanoma. Pre-treatment detection of BRAF V600-mutant ctDNA has been shown to be a prognostic factor in patients receiving BRAF/MEK inhibitor treatment. Furthermore, monitoring of ctDNA of known driver mutations can be used for treatment monitoring and detection of acquired resistance. However, results of the currently available studies need to be interpreted with caution as multiple approaches were used that are hardly comparable. So far, even with advancement of methods, there are only prognostic but no predictive biomarkers available.
Additional file 7 of The composite risk index based on frailty predicts postoperative complications in older patients recovering from elective digestive tract surgery: a retrospective cohort study
Creators: name: Li, Chun-Qing
name: Zhang, Chen
name: Yu, Fan
name: Li, Xue-Ying
name: Wang, Dong-Xin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Hematology

description: Additional file 7: Supplementary Figure 1 The area under receiver-operator characteristic curves of modified frailty index and composite risk index in predicting postoperative complications.
The Value of Communication for Mental Health
Creators: Annan, Francis
Archibong, Belinda
Publisher: name: Columbia University
Year: 2021
Subjects: Mental health
Mental health--Economic aspects
Interpersonal communication
Communication--Economic aspects
Well-being

description: Mental health disorders account for a significant share of the overall global disease burden and translate into staggeringly large economic losses, particularly in low-income countries, where people are faced with several unexpected shocks. We test whether improved communication can mitigate such mental health disorders. Partnering with a major telecommunications company, we implement low-cost communication interventions that provide mobile calling credits to a nationally representative set of low-income adults in Ghana during the COVID-19 pandemic. Individuals’ inability to make unexpected calls, need to borrow SOS airtime, and to seek digital loans decreased significantly relative to a control group. As a result, the programs led to a significant decrease in mental distress (-9.8%) and the likelihood of severe mental distress by -2.3 percentage points (a quarter of the mean prevalence), with null impact on consumption expenditure. The effects are stronger for monthly mobile credits than a lump-sum. Simple cost-benefit analysis shows that providing communication credit to low-income adults is a cost-effective policy for improving mental health. Communication – the ability to stay connected – meaningfully improves mental well-being and interventions about communication are particularly valuable when implemented as many installments.
Productivity of the declining Bearded Vulture Gypaetus barbatus population in southern Africa§
Creators: name: Krüger, Sonja C
name: Amar, Arjun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Recent research has shown that anthropogenic influences are driving the abandonment of breeding territories in the declining southern African Bearded Vulture Gypaetus barbatus meridionalis population. Survival rates appear to be low (86% for adults) due to poisoning and collisions with powerlines, which are the primary causes of death from tracked birds. However, there is no information published on the population’s current productivity levels, and whether this may be a contributing factor in the declines of this population. This information is vital for a more holistic approach to the conservation of the population. In this study we use data from breeding territory surveys between 2000 and 2016 to estimate productivity for this population. Only around 54% ± 74% (17–91%) of pairs attempted to breed each year, and although nesting success for pairs attempting to breed was relatively high (0.75 ± 0.22; 0.44–1.00), this resulted in low productivity of only 0.42 ± 0.65 (0.28–0.67) young per pair per year. These results contrast with previous surveys, suggesting the productivity may have declined over the last three decades, principally due to many pairs not attempting to breed in each year. Understanding the factors influencing productivity amongst pairs could be useful to guide conservation actions.
MODELS'17 paper (preprint long version)
Creators: name: Ramadan, Qusai
Publisher: name: figshare
Year: 2017
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: 80303 Computer System Security
subject: 120405 Models of Engineering Design
subject: FOS: Other engineering and technologies

description: Tracing and integrating security requirements throughout the developmentprocess is a key challenge in security engineering. In socio-technical systems, security requirements for the organizational and technical aspects of a system are currently dealt with separately, giving rise to substantialmisconceptions and errors. In this paper, we present a model-based security engineering framework for supporting the system design on the organizational and technical level. The key idea is to allow the involved experts to specify security requirements in the languages they are familiar with: business analysts use BPMN for procedural system descriptions; system developers use UML to design and implement the system architecture. Security requirements are captured via the language extensions SecBPMN2 and UMLsec. We provide a model transformation to bridge the conceptual gap between SecBPMN2 and UMLsec. Using UMLsec policies, various security properties of the resulting architecture can be verified. In a case study featuring an air traffic management system, we show how our framework can be practically applied.
Tibetan Wylie Workshop 1: Basic introduction to the Wylie romanization system(s) used to transcribe Tibetan script
Creators: Hartley, Lauran R.
Publisher: name: Columbia University
Year: 2020
Subjects: Tibetan language
Transliteration
Library science

description: This workshop is part 1 of a two-part workshop to explain the Wylie romanization system for transliterating the Tibetan script. Also includes instruction on searching CLIO (the online catalog at Columbia University) for Tibetan-language titles, with application for WorldCat searches as well. This workshop is continued by Tibetan Wylie Workshop 2, which can be found at https://doi.org/10.7916/d8-n95t-0y07.
MOESM1 of Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study
Creators: name: Chauvin, Anthony
name: Ravaud, Philippe
name: Moher, David
name: Schriger, David
name: Hopewell, Sally
name: Shanahan, Daniel
name: Alam, Sabina
name: Baron, Gabriel
name: Regnaux, Jean-Philippe
name: Crequit, Perrine
name: Martinez, Valeria
name: Riveros, Carolina
name: Cleach, Laurence
name: Recchioni, Alessandro
name: Altman, Douglas
name: Boutron, Isabelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1. STARD checklist. Full details of the reporting according the checklist.
MDTS: automatic complex materials design using Monte Carlo tree search
Creators: name: Thaer M. Dieb
name: Shenghong Ju
name: Yoshizoe, Kazuki
name: Zhufeng Hou
name: Shiomi, Junichiro
name: Tsuda, Koji
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Complex materials design is often represented as a black-box combinatorial optimization problem. In this paper, we present a novel python library called MDTS (Materials Design using Tree Search). Our algorithm employs a Monte Carlo tree search approach, which has shown exceptional performance in computer Go game. Unlike evolutionary algorithms that require user intervention to set parameters appropriately, MDTS has no tuning parameters and works autonomously in various problems. In comparison to a Bayesian optimization package, our algorithm showed competitive search efficiency and superior scalability. We succeeded in designing large Silicon-Germanium (Si-Ge) alloy structures that Bayesian optimization could not deal with due to excessive computational cost. MDTS is available at https://github.com/tsudalab/MDTS.
Hypothesis
Creators: name: Živnůstka, Miroslav
name: Vranka, Marek A.
name: Tomešová, Adriana
name: Blažková, Nikola
name: Chovancová, Zuzana
name: Horáková, Anna
Publisher: name: OSF Registries
Year: 2018

description: Women's preferences for hypothetical sperm donor differ from preferences for long-term mates.
The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis)
Creators: name: Yagasaki, Rina
name: Morita, Akane
name: Mori, Asami
name: Sakamoto, Kenji
name: Nakahara, Tsutomu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Metformin, a biguanide antihyperglycemic drug, can exert various beneficial effects in addition to its glucose-lowering effect. The effects of metformin are mainly mediated by AMP-activated protein kinase (AMPK)-dependent pathway. AMPK activation interferes with the action of the mammalian target of rapamycin complex 1 (mTORC1), and blockade of mTORC1 pathway suppresses pathological retinal angiogenesis. Therefore, in this study, we examined the effects of metformin on pathological angiogenesis and mTORC1 activity in the retinas of mice with oxygen-induced retinopathy (OIR). OIR was induced by exposing the mice to 80% oxygen from postnatal day (P) 7 to P10. The OIR mice were treated with metformin, rapamycin (an inhibitor of mTORC1), or the vehicle from P10 to P12 or P14. The formation of neovascular tufts, revascularization in the central avascular areas, expression of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) 2, and phosphorylated ribosomal protein S6 (pS6), a downstream indicator of mTORC1 activity, were evaluated at P10, P13, or P15. Neovascular tufts and vascular growth in the central avascular areas were observed in the retinas of P15 OIR mice. The formation of neovascular tufts, but not the revascularization in the central avascular areas, was attenuated by metformin administration from P10 to P14. Metformin had no significant inhibitory effect on the expression of VEGF and VEGFR2, but it reduced the pS6 immunoreactivity in vascular cells at the sites of angiogenesis. Rapamycin completely blocked the phosphorylation of ribosomal protein S6 and markedly reduced the formation of neovascular tufts. These results suggest that metformin partially suppresses the formation of neovascular tufts on the retinal surface by blocking the mTORC1 signaling pathway. Metformin may exert beneficial effects against the progression of ocular diseases in which abnormal angiogenesis is associated with the pathogenesis.
Additional file 8 of The composite risk index based on frailty predicts postoperative complications in older patients recovering from elective digestive tract surgery: a retrospective cohort study
Creators: name: Li, Chun-Qing
name: Zhang, Chen
name: Yu, Fan
name: Li, Xue-Ying
name: Wang, Dong-Xin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Hematology

description: Additional file 8: STROBE Statement—Checklist of items that should be included in reports of cohort studies.
IN00113 - IN00113 Tosham Graffiti 2
Creators: name: Balogh, Dániel
Publisher: name: Zenodo
Year: 2020

description: [caption id="attachment_4341" align="alignnone" width="185"] Tosham, Haryana. Graffiti as recorded by Cunningham in ASIR 5 (1875): plate XL.[/caption]
Three Perspectives on Ethnography from Ukraine: The Mysterious Tale of a Lost Hutsul Manuscript, Its Recovery, and the Dialogues that Ensued
Creators: Sonevytsky, Maria Rostyslava
Publisher: name: Columbia University
Year: 2010
Subjects: Ethnology
Ethnologists
Nationalism

description: At the historic meeting of folklorists, ethnographers and ethnomusicologists on the 70th anniversary of the founding of the Department of Ukrainian Folklore at Ivan Franko University in L'viv, Ukraine, old and new models of scholarship clashed, in ways both subtle and fierce. Generations of Ukrainian scholars, in addition to three representatives from the U.S. (myself included) took part in the meeting.1 Papers ranged from analyses in the Soviet formalist folklore style—now reinvented as the nationalist Ukrainian style—to papers exploring the archives and biographies of founders of the discipline in Ukraine (including Filaret Kolessa, after whom the department is named). Topics discussed also revealed generational rifts in what constituted valid terrain for folklore studies: when some young scholars tackled subjects such as how mass e-mail love notes can be considered modern folklore, or explored the humorous texts of Ukrainian-Canadian kolomyjky (rural Western Ukrainian dance songs) that have a vibrant second life in the diaspora, their papers would often be met with pointed questions about intellectual worth from the elders of the field, accusations of irreverence or irrelevance coquettishly or ironically rebutted by younger presenters.
universe-heat-death(1).pdf
Creators: name: Aly, Islam Atef
Publisher: name: figshare
Year: 2017
Subjects: Cosmology

description:
This paper overviews my hypothesis of the ultimate fate of the universe, showing how it will reach the heat death, and how the dark energy has the main role in the universe movement and even it's end, this paper opens a new path in the searching about the nature of dark energy, by knowing that it's the reason why the universe is expanding, cooling and losing energy. And to note that in this paper we based on that the universe is closed.
Through the Eyes of a Young Amazigh
Creators: Handaine, Amnai
Publisher: name: Columbia University
Year: 2019
Subjects: Human rights
Indigenous peoples
Indigenous youth
Indigenous peoples--Language
Berbers

description: Through my story, I wanted to share both my personal experiences and those of other young Amazigh people around me who also want to provide their visions and share their conditions. Their stories have been shared with me through meetings, sometimes-animated discussions, and provided testimonies of youth still living in Morocco, who have a more in-depth vision of the Amazigh situation. That vision is, of course, a subjective point of view conditioned by different life experiences which could be different from one person to another.
Tibetan Wylie Workshop 2: Advanced introduction to the Wylie romanization system(s) used to transcribe Tibetan script
Creators: Hartley, Lauran R.
Publisher: name: Columbia University
Year: 2020
Subjects: Tibetan language
Transliteration
Library science

description: Advanced introduction to the Wylie romanization system(s) used to transcribe Tibetan script, including illustration of how to romanize and search library catalogs for Sanskrit and other foreign terms rendered in Tibetan. This is a continuation of Tibetan Wylie Workshop 1, which can be found at https://doi.org/10.7916/d8-88pw-0r74.
MOESM1 of Population-level analysis reveals the widespread occurrence and phenotypic consequence of DNA methylation variation not tagged by genetic variation in maize
Creators: name: Xu, Jing
name: Chen, Guo
name: Hermanson, Peter
name: Xu, Qiang
name: Sun, Changshuo
name: Chen, Wenqing
name: Kan, Qiuxin
name: Li, Minqi
name: Crisp, Peter
name: Yan, Jianbing
name: Li, Lin
name: Springer, Nathan
name: Li, Qing
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Additional file 1: Figure S1. DMR validation. Comparison between DNA methylation of the capture based assay and the whole genome bisulfite sequencing assay (WGBS) in DMRs between B73 and Mo17. Figure S2. Distribution of DMR size and genomic features. Figure S3. DNA methylation can reflect genetic distances. Figure S4. DNA methylation levels in DMRs are different among maize subgroups. Figure S5. Summary of DMRs associated with SNPs and structure variants (SVs). Figure S6. The associations between gene expression and DNA methylation. Figure S7. DMRs affect gene expression as a cause. Figure S8. Mendelian randomization analysis. Figure S9. The association between DMR and metabolic trait chr di-C.
Two sterols, two bilayers: insights on membrane structure from molecular dynamics
Creators: name: Monje-Galvan, Viviana
name: Klauda, Jeffery B.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Cholesterol (CHL) and ergosterol (ERG) are two predominant sterols in eukaryotic cells. The differences in their chemical structure can influence membrane structure and dynamics; this study discusses the effect CHL and ERG have on yeast membrane models with characteristic lipid composition for the endoplasmic reticulum (ER) and the trans-Golgi network (TGN) of yeast Saccharomyces cerevisiae. Molecular dynamics simulations were used to understand the atomic details of the sterols’ interaction with lipid bilayers that have both saturated and unsaturated tails as well as neutral and charged headgroups. Our models include phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol lipids to mimic the environment of the ER and TGN. The models for each organelle are identical, respectively, except for the sterol type. The overall surface area per lipid has no statistical difference between models for the same organelle, 63.6 ± 0.4 Å2 in the ER and 60.9 ± 0.4 Å2 in the TGN with either ERG or CHL. However, the compressibility modulus is approximately 30% lower in the models with ERG. We analyse this difference based on the sterols’ chemical structure and examine other membrane properties such as the lipid tails order parameters, bilayer thicknesses, sterol tilt angles and sterol spatial orientation with respect to the lipid tails to compare trends with existing data from simulation as well as experiment. This is the first study, to our knowledge, to examine the effect of sterol type on multi-lipid bilayer models with all-atom molecular dynamics.
Traversing the landscape of experimental power
Creators: Brock, J. Michelle
Vasilaky, Kathryn N.
Publisher: name: Columbia University
Year: 2016
Subjects: Experimental economics
Experimental design
Statistical power analysis
Economics

description: We present an overview of the use of power calculations in experimental economics as well as other disciplines. We review the methodology proposed by the field of economics as well the pitfalls in failing to incorporate power calculations in lab and field experiments. We write this note to further draw attention to the issue, and to make a case that details of power calculations should be reported in experimental economics papers. This note should serve as a reference and overview to researchers in experimental economics on power calculations.
New Insights and Methods for Studying the Impact of Lipid Excipients on the Precipitation Behaviour of Poorly Water-Soluble Drugs
Creators: name: JAMAL TARIQ KHAN
Publisher: name: Monash University
Year: 2017
Subjects: Pharmacology

description: A large number of newly discovered drugs are not suited to conventional dose forms, such as tablets, for oral drug delivery. Lipid based formulations are an alternative dose form, which provide a means to successfully deliver these drugs by making use of the body's natural digestion mechanism. The issue of drug precipitation, however, has hindered the successful development of these formulations. This work examined the factors that govern drug precipitation during lipid formulation digestion, and showed that a level of control can be attained, which could ultimately assist in optimizing the development of lipid formulations.
title: ECM mechanics and spatiotemporal energetics in pancreatic cancer
Creators: name: Papalazarou, Vasileios
Publisher: name: University of Glasgow
Year: 2019

description: Unbalanced cues from the extracellular matrix (ECM) govern pancreatic tumorigenesis and dissemination. Stiff fibrotic stroma and cancer cell mechanosensing regulate cell proliferation, migration and invasion. Such key processes are highly dependent on energy availability and need to be fuelled by metabolic adaptations to tumorigenic microenvironments. However, it is still unknown how ECM mechanics influence cellular energetics and metabolism as well as how cells meet their ATP requirements during invasion and metastasis. We found that pancreatic cancer cells tune their metabolic networks to favour ATP production on stiff ECM. This process appeared dependent on mitochondrial fusion and polarization on stiff substrata as well as in pseudopods formed during ECM invasion. In addition, this was accompanied by a mechano-dependent regulation of ATP recycling through the creatine phosphagen system. The cytoplasmic creatine kinase CKB was expressed on stiff substrata in a YAP dependent manner providing a critical advantage to the invasion capacity of pancreatic cancer cells. Collectively our results indicate that ECM mechanics can positively regulate tumour invasion by favouring ATP production and sharpening the gradient of ATP vs ADP through CKB activity. Our study highlights the importance of this ATP recycling circuit as a mechanism generating an efficient energy balance within the cytoplasm boosting invasion. Interestingly, targeting creatine phosphorylation hindered migration and invasion in 2D and 3D, revealing CKB as a potentially druggable target against the spread of pancreatic cancer.
MOESM2 of Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study
Creators: name: Chauvin, Anthony
name: Ravaud, Philippe
name: Moher, David
name: Schriger, David
name: Hopewell, Sally
name: Shanahan, Daniel
name: Alam, Sabina
name: Baron, Gabriel
name: Regnaux, Jean-Philippe
name: Crequit, Perrine
name: Martinez, Valeria
name: Riveros, Carolina
name: Cleach, Laurence
name: Recchioni, Alessandro
name: Altman, Douglas
name: Boutron, Isabelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 2. Minor changes to the protocol. Details of the wording used to describe the primary outcome that was slightly modified.
Artifact paper
Creators: name: Ramadan, Qusai
Publisher: name: figshare
Year: 2017
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences
subject: 80303 Computer System Security

description: We present the artifact submission for our paper ofthe same name, to be presented at the MoDELS conference 2017in Austin, TX. Our submission includes the model transformationfrom SecBPMN2 to UMLsec models as well as four exampleSecBPMN2 models from the Air Traffic Management Systemcase study. We explain the process of using the transformation,and the verification of the generated UMLsec models using theCARiSMA tool.
MARKET CITY DEVELOPMENT PADDY'S MARKET. Archaeological Excavation Volume 4 Specialist Reports
Creators: name: O'Hea, Margaret
name: Carney, M.
name: Rossi, M.
name: Thorp, W.
name: Lowe, A.,
name: Lindbergh, J.
name: Sparks, R.
Publisher: name: The University of Adelaide
Year: 2017
Subjects: Archaeology

description: Report prepared for Rockvale Pty Ltd, September 1993: pottery, glass, metal, leather, building materials from Paddy's Markets development at Darling Harbour, Sydney.

Time Period: 1840s to 1910
Geospatial Location: Sydney, NSW
Unaccounted For: Indigenous Peoples as Victims of Conflicts in Africa
Creators: Barume, Albert K.
Publisher: name: Columbia University
Year: 2017
Subjects: Human rights
Indigenous peoples
Indigenous peoples--Legal status, laws, etc.
Indigenous peoples--Land tenure
Conflict management

description: This paper argues that conflicts affecting Africa have particularly impacted Indigenous Peoples in three major ways. Firstly, there are African Indigenous communities caught up in conflicts between major groups. Secondly, there are African Indigenous Peoples whose lands and territories are militarized for various reasons and that are, to a certain extent, forced to join armed conflicts. Thirdly, there are African Indigenous Peoples involved in land-related disputes resulting in open or latent conflicts, including with states and with private businesses.
Unit Test Virtualization with VMVM
Creators: Bell, Jonathan Schaffer
Kaiser, Gail E.
Publisher: name: Columbia University
Year: 2013
Subjects: Computer science

description: Testing large software packages can become very time intensive. To address this problem, researchers have investigated techniques such as Test Suite Minimization. Test Suite Minimization reduces the number of tests in a suite by removing tests that appear redundant, at the risk of reducing fault-finding ability since it can be difficult to identify which tests are truly redundant. We take a completely different approach to solving the same problem of long running test suites by instead reducing the time needed to execute each test, an approach that we call Unit Test Virtualization. We describe the empirical analysis that we performed to ground our approach and provide an implementation of Unit Test Virtualization targeting Java applications. We evaluated our implementation, VMVM, using 20 real-world Java applications and found that it reduces test suite execution time by up to 97 percent (on average, 62 percent) when compared to traditional unit test execution. We also compared VMVM to a well known Test Suite Minimization technique, finding the reduction provided by VMVM to be four times greater, while still executing every test with no loss of fault-finding ability.
Impact of some antiviral drugs on health care utilization for patients with COVID-19: a systematic review and meta-analysis
Creators: name: Wei, Bincai
name: Zhang, Ruhao
name: Zeng, Huatang
name: Wu, Liqun
name: He, Rongxin
name: Zheng, Junyao
name: Xue, Hao
name: Liu, Jinlin
name: Liang, Fengchao
name: Zhu, Bin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: We aimed to assess the impact of antiviral drugs (fluvoxamine,remdesivir, lopinavir/ritonavir (LPV/r), molnupiravir, andnirmatrelvir/ritonavir (NRV/r)) on health care utilization (HCU) inCOVID-19 patients. We summarized findings from randomized controlledtrials (RCTs) and observational studies. We systematically searched four medical databases (PubMed, Web of Science, Embase, Cochrane Library) for COVID-19 studies up to February 15, 2023. A comprehensive review, meta-analysis, sensitivity analysis, and subgroup analysis were conducted. Pooled effects with 95% confidence intervals (CIs) were calculated for antiviral drugs' impact on hospitalization, mechanical ventilation (MV), and intensive care unit (ICU) outcomes. Our analysis included 34 studies (584,978 patients). Meta-analysisindicated potential benefits: remdesivir and molnupiravir potentiallyreduced MV risk, and NRV/r correlated with lower hospitalizationrates. However, LPV/r did not notably curb HCU. Remdesivir waspreferable for high-risk COVID-19 patients, while molnupiravir andNRV/r were recommended for those aged 60 and above. Remdesivir, molnupiravir, and NRV/r may reduce HCU during the COVID-19 pandemic. However, due to limited study details and significant heterogeneity in effect estimates, further precise evidence is crucial, especially concerning emerging variants.
MODELS'17 paper (preprint version)
Creators: name: Ramadan, Qusai
Publisher: name: figshare
Year: 2017
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: Tracing and integrating security requirements throughout the development process is a key challenge in security engineering. In socio-technical systems, security requirements for the organizational and technical aspects of a system are currently dealt with separately, giving rise to substantial misconceptions and errors. In this paper, we present a model-based security engineering framework for supporting the system design on the organizational and technical level. The key idea is to allow the involved experts to specify security requirements in the languages they are familiar with: business analysts use BPMN for procedural system descriptions; system developers use UML to design and implement the system architecture. Security requirements are captured via the language extensions SecBPMN2 and UMLsec. We provide a model transformation to bridge the conceptual gap between SecBPMN2 and UMLsec. Using UMLsec policies, various security properties of the resulting architecture can be verified. In a case study featuring an air traffic management system, we show how our framework can be practically applied.
Efficient Generation of Electrical Energy Using Solar Panels
Creators: name: Fayzullayev, Yorqinbek
Publisher: name: Zenodo
Year: 2025

description: Solar panels are among the most promising technologies for achieving sustainable energy goals. This article discusses the physical principles behind photovoltaic systems, analyzes various environmental and technological factors affecting their efficiency, and explores innovative solutions for improving electricity generation. Detailed recommendations are provided to maximize the output of solar panels, supported by diagrams and references to recent scientific research.
Validation of the Mental Illness Sexual Stigma Questionnaire (MISS-Q) in a sample of Brazilian adults in psychiatric care
Creators: Wainberg, Milton L.
Norcini Pala, Andrea
Cournos, Francine
McKinnon, Karen
Publisher: name: Columbia University
Year: 2017
Subjects: Mental illness
Sexual health
Psychiatric hospital care
Stigmatization

description: Objective: We evaluated the psychometric properties of a new instrument "Mental Illness Sexual Stigma Questionnaire" (MISS-Q). Methods: We interviewed 641 sexually active adults (ages 18-80) attending public outpatient psychiatric clinics in Rio de Janeiro about their stigma experiences. Results: Nine factors were extracted through exploratory factor analysis (EFA) and labeled: 'individual discrimination by others'; 'staff willingness to talk about sexuality'; 'staff and family prohibitions'; 'sexual devaluation of self'; 'perceived attractiveness'; 'mental illness concealment'; 'perceived sexual role competence'; 'withdrawal'; and 'locus of social-sexual control'. 'Withdrawal' and 'locus of social-sexual control' showed poor psychometric properties and were excluded from further analysis. The remaining seven factors had high factorial loadings (.39 to .86), varying from sufficient to optimal reliability (Ordinal α ranged from .57 to .88), and good convergent and discriminant validity. Conclusions: The resulting MISS-Q is the first instrument assessing mental illness sexual stigma with demonstrated psychometric properties. It may prove useful in reducing stigma, protecting sexual health, and promoting recovery. Keywords: Stigma; psychometric assessment; severe mental illness; sexual and romantic relationships.
Co-failing, Solo-failing, and Others: Impacts on relationship and goal outcomes
Creators: name: Dominick, Janna Kline
Publisher: name: OSF Registries
Year: 2018

description: During this study, participants were randomly assigned to imagine a self-control failure, either alone, together with others, or in the presence of another person. We explore impacts on emotional experiences, personal responsibility, goal-shifting, and outcomes related to goal pursuit such as goal impact and future intentions.
Weaponizing the Story: Chechen and Russian Media Operations
Creators: Billingsley, Dodge
Publisher: name: Columbia University
Year: 2009
Subjects: Chechen Civil War (Chechni︠a︡, Russia : 1994- )
Mass media and war
Mass media policy

description: While “warfare remains a violent clash of interests between organized groups characterized by the use of force,” the media war was, and still is, a critical component for both Russian and Chechen strategies in the fight for Chechnya. The wars in Chechnya were won and lost, in large part, by the attention or lack thereof on the part of both sides to information operations, specifically media operations. The Chechen and Russian approaches to media operations were significantly different during the first war (1994-1996); there was also a discernible shift in the nature of media operations conducted by both sides during the second war (1999-present).
Violent conflict exacerbated drought-related food insecurity between 2009 and 2019 in sub-Saharan Africa
Creators: Anderson, Weston
Taylor, Charles
McDermid, Sonali
Ilboudo-Nebie, Elisabeth
Seager, Richard
Schlenker, Wolfram
Cottier, Fabien
de Sherbinin, Alex
Mendeloff, Dara
Markey, Kelsey
Publisher: name: Columbia University
Year: 2021
Subjects: Food security
Droughts
Political violence

description: Conflict, drought and locusts are leading concerns for African food security but the relative importance and spatiotemporal scale of crises resulting from each hazard is poorly characterized. Here we use continuous, subnational data to demonstrate that the rise of food insecurity across sub-Saharan Africa that began in 2014 is attributable to an increase in violent conflict, particu- larly in South Sudan and Nigeria. Although drought remains a leading trigger of food crises, the prevalence of drought-related crises did not increase from 2009 to 2018. When exposed to drought, pastoralists experienced more widespread, severe and long-lasting food crises than people living in agricultural zones. Food insecurity remained elevated in pastoral regions for 2 years following a drought, while agricultural regions returned to pre-drought food-security levels in ~12 months. The few con- firmed famines during the 2009–2018 period coincided with both conflict and drought, while locusts had little effect on food security during this period.
title: 01_2175
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
MOESM3 of Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study
Creators: name: Chauvin, Anthony
name: Ravaud, Philippe
name: Moher, David
name: Schriger, David
name: Hopewell, Sally
name: Shanahan, Daniel
name: Alam, Sabina
name: Baron, Gabriel
name: Regnaux, Jean-Philippe
name: Crequit, Perrine
name: Martinez, Valeria
name: Riveros, Carolina
name: Cleach, Laurence
name: Recchioni, Alessandro
name: Altman, Douglas
name: Boutron, Isabelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 3. The search strategy in Medline via PubMed. Full list of search terms and filters.
c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA
Creators: Islam, Md Ashraful
Thomas, Shelia D.
Vundavalli, Murty V.
Sedoris, Kara J.
Miller, Donald M.
Publisher: name: Columbia University
Year: 2014
Subjects: DNA
Cell death
Eukaryotic cells--Genetics

description: Quadruplex-forming DNA sequences are present throughout the eukaryotic genome, including in telomeric DNA. We have shown that the c-Myc promoter quadruplex-forming sequence Pu-27 selectively kills transformed cells (Sedoris, K. C., Thomas, S. D., Clarkson, C. R., Muench, D., Islam, A., Singh, R., and Miller, D. M. (2012) Genomic c-Myc quadruplex DNA selectively kills leukemia. Mol. Cancer Ther. 11, 66-76). In this study, we show that Pu-27 induces profound DNA damage, resulting in striking chromosomal abnormalities in the form of chromatid or chromosomal breaks, radial formation, and telomeric DNA loss, which induces γ-H2AX in U937 cells. Pu-27 down-regulates telomeric shelterin proteins, DNA damage response mediators (RAD17 and RAD50), double-stranded break repair molecule 53BP1, G2 checkpoint regulators (CHK1 and CHK2), and anti-apoptosis gene survivin. Interestingly, there are no changes of DNA repair molecules H2AX, BRCA1, and the telomere maintenance gene, hTERT. ΔB-U937, where U937 cells stably transfected with deleted basic domain of TRF2 is partially sensitive to Pu-27 but exhibits no changes in expression of shelterin proteins. However, there is an up-regulation of CHK1, CHK2, H2AX, BRCA1, and survivin. Telomere dysfunction-induced foci assay revealed co-association of TRF1with γ-H2AX in ATM deficient cells, which are differentially sensitive to Pu-27 than ATM proficient cells. Alt (alternating lengthening of telomere) cells are relatively resistant to Pu-27, but there are no significant changes of telomerase activity in both Alt and non-Alt cells. Lastly, we show that this Pu-27-mediated sensitivity is p53-independent. The data therefore support two conclusions. First, Pu-27 induces DNA damage within both telomeric and nontelomeric regions of the genome. Second, Pu-27-mediated telomeric damage is due, at least in part, to compromise of the telomeric shelterin protein complex.