cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: of Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings
Creators: name: Luo, Aixiang
name: Cheng, Dehua
name: Yuan, Shimin
name: Li, Haiyu
name: Du, Juan
name: Zhang, Yang
name: Yang, Chuanchun
name: Lin, Ge
name: Zhang, Wenyong
name: Tan, Yue-Qiu
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Environmental Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S1. The Gesell Development Scale results of the patients. (DOCX 16Â kb)
Management and treatment options of esophagogastric junction cancer
Creators: name: Niclauss, Nadja
Publisher: name: Université de Genève
Year: 2019
Subjects: info:eu-repo/classification/ddc/617
Esophagogastric junction cancer
Multimodal treatment

description: Esophagogastric junction (EGJ) cancer shows a rising incidence in Western countries. It is diagnosed by endoscopy and classified into Siewert type I-III carcinoma based on its location in relation to the anatomical cardia. Apart from endoscopic resection of early stage carcinoma, surgery is the treatment of choice. The common surgical approach for Siewert type I carcinoma is an Ivor Lewis esophagectomy with two-field lymphadenectomy and for Siewert type III carcinoma a transhiatal extended gastrectomy with D2 lymphadenectomy. Minimally invasive procedures show similar oncologic outcomes while mainly pulmonary complications occur less frequently compared to open procedures. A multimodal treatment is standard of care in resectable EGJ carcinoma. Both perioperative chemotherapy and neoadjuvant chemoradiotherapy are treatment options. Systemic chemotherapy is the mainstay of palliative therapy in metastatic or inoperable locally advanced EGJ cancer. Checkpoint inhibitors are emergent immunotherapies and have shown promising results in patients with chemotherapy-refractory advanced and metastatic EGJ cancer.
Maternal Post-traumatic Stress and Response to Toddler Distress : What is the Impact on Mutual Emotion Regulation and the Child's Social-Emotional Development?
Creators: name: Schechter, Daniel
Publisher: name: Université de Genève
Year: 2010
Subjects: info:eu-repo/classification/ddc/610
Trauma
PTSD
Parentalité
Pédopsychiatrie
Psychobiologie développementale
Violence

description: Papers and preliminary findings from three different programs of research examining the effects of maternal violent traumatization on the early parent-child relationship and on child social-emotional development, directed by Dr. Schechter and spanning the period 1999 to the present, are reviewed and compiled. These three programs of research involved the following samples: 1) Clinical Sample of Referred Mothers and Toddlers during his NIH Research Fellowship (N=41) and the follow-up of the young children 2 years later (N=25), 2) Pediatrics Community Clinics Sample of Mothers and Toddlers during the NIH Research Career Award (N=104) that included the imaging study (N=20), and finally 3) the current study in Geneva with preliminary results thus far (N=13) have continued to characterize how interpersonal violence-related posttraumatic psychopathology impacts the child-parent relationship during formative development of emotion regulation in the child, with demonstrable repercussions for the child in preschool and early school-age years. Specifically, the overarching hypothesis that links these 3 different research programs tested and supported the hypothesis that mothers who have experienced interpersonal violence and who suffer from related posttraumatic stress disorder (PTSD) tend to have particular difficulties in the regulation of their own emotion and arousal, particularly when faced with helpless states of mind in their young children or themselves. These difficulties, which can be viewed at the level of maternal mental representations and self-reported stress, behavior, physiology, and neural activity are associated with impairment in their parental function of assisting their young children with regulation of their emotion, arousal, and aggression.
Additional file 2: of Maternal interchromosomal insertional translocation leading to 1q43-q44 deletion and duplication in two siblings
Creators: name: Luo, Aixiang
name: Cheng, Dehua
name: Yuan, Shimin
name: Li, Haiyu
name: Du, Juan
name: Zhang, Yang
name: Yang, Chuanchun
name: Lin, Ge
name: Zhang, Wenyong
name: Tan, Yue-Qiu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S2. The list of primers for PCR amplification of chromosomal breakpoint regions. (DOCX 16Â kb)
Quality assessment of clinical practice guidelines for eosinophilic esophagitis using the AGREE II instrument
Creators: name: Lucendo, Alfredo J.
name: Arias, Ángel
name: Redondo-González, Olga
name: Molina-Infante, Javier
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Background: High-quality evidence-based clinical practice guidelines can guide diagnosis and treatment to optimize outcomes. We aimed to systematically review the quality of international guidelines on eosinophilic esophagitis (EoE). Methods: MEDLINE and Scopus databases were searched for appropriate guidelines up to 2016. Two gastroenterologists and two methodologists independently evaluated the documents using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument. Results: Amongst the 25 records initially retrieved, four guidelines developed by recognized scientific organizations met inclusion criteria. AGREE II results varied widely across domains, but none achieved an overall assessment score of over 60%. Scope and purpose (61.82 ± 19.24%), clarity of presentation (57.13 ± 40.56%) and editorial independence (93.75 ± 1.69%) showed the highest mean rating, whereas stakeholder involvement (28.82 ± 11.19%), rigor of development (32.29 ± 12.02%) and applicability (21.62 ± 7.14%) did not reach quality thresholds. Intraclass correlation coefficients for agreement was excellent among appraisers (0.903), between gastroenterologists and methodologists (0.878) and for each individual guideline (0.838 to 0.955). Conclusion: Clinical practice guidelines for EoE vary significantly in quality, are invariably limited and currently, none can be ‘strongly recommended’.
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor.
Creators: name: Frei, J Niclas
name: Broadhurst, Richard W
name: Bostock, Mark J
name: Solt, Andras
name: Jones, Andrew J Y
name: Gabriel, Florian
name: Tandale, Aditi
name: Shrestha, Binesh
name: Nietlispach, Daniel
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: G-protein-coupled receptors (GPCRs) are allosteric signaling proteins that transmit an extracellular stimulus across the cell membrane. Using 19F NMR and site-specific labelling, we investigate the response of the cytoplasmic region of transmembrane helices 6 and 7 of the β1-adrenergic receptor to agonist stimulation and coupling to a Gs-protein-mimetic nanobody. Agonist binding shows the receptor in equilibrium between two inactive states and a pre-active form, increasingly populated with higher ligand efficacy. Nanobody coupling leads to a fully active ternary receptor complex present in amounts correlating directly with agonist efficacy, consistent with partial agonism. While for different agonists the helix 6 environment in the active-state ternary complexes resides in a well-defined conformation, showing little conformational mobility, the environment of the highly conserved NPxxY motif on helix 7 remains dynamic adopting diverse, agonist-specific conformations, implying a further role of this region in receptor function. An inactive nanobody-coupled ternary receptor form is also observed.
Newspaper Consumption in the Mobile Age
Creators: name: Thurman, Neil
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This article combines data from the British National Readership Survey, the Audit Bureau of Circulations, and comScore to calculate how much audience attention newspapers’ print, personal computer (PC), and mobile platforms attract. The results show that, of the time spent with 11 UK national newspaper brands by their British audiences, 88.5 per cent still comes via their print editions, 7.49 per cent via mobiles, and just 4 per cent via PCs. The study reveals that the “share of consumption” of UK national newspaper brands (when measured by time spent) is less evenly distributed than commonly understood, conforming better to a logarithmic pattern than a linear one, and that a single brand—The Mail—has close to a 30 per cent market share. Such data should inform debates on, and the regulation of, media plurality. For publishers, this research calls into question the transition from print to online, showing how “dead-tree” editions are their most important platform. However, the circulation of print editions is in steep decline and newspapers’ fortunes are falling almost as steeply. Unless the qualities that make newsprint so much more engaging than online journalism can be harnessed to propel a reading resurgence, newspapers’ decline will continue, with important social, cultural, and political consequences.
A large-scale species level dated angiosperm phylogeny for evolutionary and ecological analyses.
Creators: name: Janssens, Steven B
name: Couvreur, Thomas L P
name: Mertens, Arne
name: Dauby, Gilles
name: Dagallier, Leo-Paul M J
name: Vanden Abeele, Samuel
name: Vandelook, Filip
name: Mascarello, Maurizio
name: Beeckman, Hans
name: Sosef, Marc
name: Droissart, Vincent
name: Van Der Bank, Michelle
name: Maurin, Olivier
name: Hawthorne, William
name: Marshall, Cicely
name: Réjou-Méchain, Maxime
name: Beina, Denis
name: Baya, Fidele
name: Merckx, Vincent
name: Verstraete, Brecht
name: Hardy, Olivier
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Evolution
subject: Phylogeny
subject: Angiosperms
subject: Large-scale Dating Analyses

description: Phylogenies are a central and indispensable tool for evolutionary and ecological research. Even though most angiosperm families are well investigated from a phylogenetic point of view, there are far less possibilities to carry out large-scale meta-analyses at order level or higher. Here, we reconstructed a large-scale dated phylogeny including nearly 1/8th of all angiosperm species, based on two plastid barcoding genes, matK (incl. trnK) and rbcL. Novel sequences were generated for several species, while the rest of the data were mined from GenBank. The resulting tree was dated using 56 angiosperm fossils as calibration points. The resulting megaphylogeny is one of the largest dated phylogenetic tree of angiosperms yet, consisting of 36,101 sampled species, representing 8,399 genera, 426 families and all orders. This novel framework will be useful for investigating different broad scale research questions in ecological and evolutionary biology.
Table S2 Environmental co-variates (posterior mean showed) and their Bayesian Credibility Intervals [lower (l-) and upper (u-) BCI and p-MCMC] of the four Linear Mixed Models (LMMs) fitted for the four behaviors studied in this study and the habitat characteristics of the center of the home range (Grain size and depth). from Repeatability of circadian behavioural variation revealed in free-ranging marine fish
Creators: name: Alós, Josep
name: Martorell, Martina
name: Campos-Candela, Andrea
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Repeatable between-individual differences in the behavioural manifestation of underlying circadian rhythms determine chronotypes in humans and terrestrial animals. Here, we have repeatedly measured three circadian behaviours, awakening time, rest onset related and rest duration in the free-ranging pearly razorfish, Xyrithchys novacula, facilitated by acoustic tracking technology and Hidden Markov Models. In addition, daily travelled distance, a standard measure of daily activity as fish personality trait, was repeatedly assessed using a State-Space Model. We have decomposed the variance of these four behavioural traits using linear mixed models and estimated repeatability scores (R) while controlling for environmental co-variates: year of experimentation, spatial location of the activity, fish size and gender and their interactions. Between- and within-individual variance decomposition revealed significant Rs in all traits suggesting high predictability of individual circadian behavioural variation and the existence of chronotypes. The decomposition of the correlations among chronotypes and the personality trait studied here into between- and within-individual correlations did not reveal any significant correlation at between-individual level. We therefore propose circadian behavioural variation as independent axis of the fish personality and the study of chronotypes and their consequences as a novel dimension understanding within-species fish behavioural diversity.
Additional file 1: of Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1â 1 plasmid
Creators: name: Yao, Yuan
name: Enkhtsetseg, Sukhbold
name: Odsbu, Ingvild
name: Fan, Lifei
name: Morigen, Morigen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Ecology
subject: Developmental Biology
subject: Plant Biology

description: Figure S1. Illustration for determination of the B-, C and D-period in an exponentially growing cluture. (DOCX 215 kb)
The impact of acetabular labral tears on sexual activity in women.
Creators: name: Raut, Shruti
name: Kamal, Jessica
name: Norrish, Alan
name: Khanduja, Vikas
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019

description: A healthy sex-life is an important component of a good quality of life. However, sexual function may be inhibited in women with acetabular labral tears because of the labrum being caught between the femoral head neck junction and the acetabular rim during flexion and/or abduction of the hip. The aim of this article is to quantify the effect that acetabular labral tears may have on the sexual lives of women and to establish the extent to which they may be expected to resolve after arthroscopic intervention. The article also highlights the importance of including questions related to the impact on sexual activity as a routine part of our taking history for a young adult with hip pain, to gain a true appreciation of the impact the symptoms have on the day-to-day lives of our patients.
Two new Keggin-type polyoxometalate-based organic-inorganic hybrid compounds with metal ions and chelate ligands
Creators: name: Jia, Shi-Fang
name: Hao, Xiu-Li
name: Ma, Yuan-Yuan
name: Wang, Hong-Yi
name: Li, Yang-Guang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Two new hybrid compounds with chemical formulas [Co(L1)2(H2O)2]2[SiW12O40]·6H2O (1) and [Cu2(C9H22 N)2(L2)2][SiW12O40]·2H2O (2) (L1 = 3,3′-diamino-5,5′-bis(1H-1,2,4-triazole), L2 = 1,2-bis(3-(2-pyridyl)pyrazole-1-ylmethyl)benzene, C9H22 N = tripropylamine) were prepared in a hydrothermal reaction system containing Keggin-type polyoxometalates (POMs), transition metal (TM) salts (cobalt salts and copper salts), and chelate L1/L2 ligands. X-ray structural analysis reveals that 1 and 2 possess 3-D supramolecular host frameworks with large cavities and the polyoxoanions SiW12 reside in these cavities as the guest templates. The photocatalytic activities of 1 and 2 were investigated. Both compounds show efficient catalytic activity for degradation of RhB with 1 > 2. The loading amount of the POM units and the structural features of these POM-based organic-inorganic hybrid compounds may be necessary factors that affect the activity of catalysts in the photocatalytic degradation.
Figure S1 Map of the study area and array of acoustic omnidirectional receivers where individuals of free-ranging peraly razorfish, Xyrchthys novacula, were electronically tracked from Repeatability of circadian behavioural variation revealed in free-ranging marine fish
Creators: name: Alós, Josep
name: Martorell, Martina
name: Campos-Candela, Andrea
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Repeatable between-individual differences in the behavioural manifestation of underlying circadian rhythms determine chronotypes in humans and terrestrial animals. Here, we have repeatedly measured three circadian behaviours, awakening time, rest onset related and rest duration in the free-ranging pearly razorfish, Xyrithchys novacula, facilitated by acoustic tracking technology and Hidden Markov Models. In addition, daily travelled distance, a standard measure of daily activity as fish personality trait, was repeatedly assessed using a State-Space Model. We have decomposed the variance of these four behavioural traits using linear mixed models and estimated repeatability scores (R) while controlling for environmental co-variates: year of experimentation, spatial location of the activity, fish size and gender and their interactions. Between- and within-individual variance decomposition revealed significant Rs in all traits suggesting high predictability of individual circadian behavioural variation and the existence of chronotypes. The decomposition of the correlations among chronotypes and the personality trait studied here into between- and within-individual correlations did not reveal any significant correlation at between-individual level. We therefore propose circadian behavioural variation as independent axis of the fish personality and the study of chronotypes and their consequences as a novel dimension understanding within-species fish behavioural diversity.
Flickering nanometre-scale disorder in a crystal lattice tracked by plasmonic flare light emission.
Creators: name: Carnegie, Cloudy
name: Urbieta, Mattin
name: Chikkaraddy, Rohit
name: De Nijs, Bart
name: Griffiths, Jack
name: Deacon, William M
name: Kamp, Marlous
name: Zabala, Nerea
name: Aizpurua, Javier
name: Baumberg, Jeremy J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: The dynamic restructuring of metal nanoparticle surfaces is known to greatly influence their catalytic, electronic transport, and chemical binding functionalities. Here we show for the first time that non-equilibrium atomic-scale lattice defects can be detected in nanoparticles by purely optical means. These fluctuating states determine interface electronic transport for molecular electronics but because such rearrangements are low energy, measuring their rapid dynamics on single nanostructures by X-rays, electron beams, or tunnelling microscopies, is invasive and damaging. We utilise nano-optics at the sub-5nm scale to reveal rapid (on the millisecond timescale) evolution of defect morphologies on facets of gold nanoparticles on a mirror. Besides dynamic structural information, this highlights fundamental questions about defining bulk plasma frequencies for metals probed at the nanoscale.
Additional file 2: of Methylated genomic loci encoding microRNA as a biomarker panel in tissue and saliva for head and neck squamous cell carcinoma
Creators: name: Cao, Yu
name: Green, Katherine
name: Quattlebaum, Steve
name: Milam, Ben
name: Lu, Ling
name: Gao, Dexiang
name: He, Hui
name: Li, Ningning
name: Gao, Liwei
name: Hall, Francis
name: Whinery, Matthew
name: Handley, Elyse
name: Ma, Yi
name: Xu, Tao
name: Jin, Feng
name: Xiao, Jing
name: Wei, Minjie
name: Smith, Derek
name: Bornstein, Sophia
name: Gross, Neil
name: Pyeon, Dohun
name: Song, John
name: Lu, Shi-Long
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Relative methylation levels of mgmiRs in human HNSCC cell lines and normal head and neck cell lines. Table S2. Relative methylation level in tissues from 189 HNSCC patients and 92 normal controls. Table S3. Univariate and multivariable logistic regression with continuous variables in tissues. Table S4. Relative methylation level in saliva from 86 HNSCC patients and 108 normal controls. Table S5. Univariate and multivariable logistic regression with continuous variables in saliva. (DOCX 42Â kb)
Investigating the impact of grinding techniques on shape properties of ground volcanic glass: insights from ball mill, vibrating pulverizer, and rotor mill
Creators: name: Angelopoulos, Panagiotis M.
name: Anastassakis, Georgios
name: Taxiarchou, Maria
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: The shape properties of fine volcanic glass particles influence their behavior in various applications, such as fillers in polymers, pozzolanic additives in cement, and coatings, while studying the effect of grinding device can optimize their performance. We studied the effect of grinding device (ball mill, vibrating pulverizer, and rotor mill) on the shape of glassy mineral particles grinded to −150 and −300 + 150 μm granulometric grades through image processing of SEM images for the determination of critical shape descriptors (circularity, aspect ratio, and roundness) and Feret diameter. Statistical differences in shape properties were evaluated using the analysis of variance (ANOVA) technique to determine their significance. The results indicated that grinding device type had a modest influence on particle shape, particularly in finer size fractions. Notably, fine ground particles from the ball mill exhibited higher circularity, with the difference shown to be statistically significant. For coarser particles, those ground with the vibrating pulverizer demonstrated the lowest aspect ratio and highest roundness, although the effect of the grinding device was less pronounced. While certain differences in particle shape properties were observed, no conclusive evidence was found to suggest that these variations translate into measurable differences in filler performance.
Supplementary Methods and TablesThis file includes details about methods and parameters used, as well as supplementary results on analyses ofphenotype and whole genome analyses. from A novel locus on chromosome 1 underlies the evolution of a melanic plumage polymorphism in a wild songbird
Creators: name: Bourgeois, Yann X. C.
name: Delahaie, Boris
name: Gautier, Mathieu
name: Lhuillier, Emeline
name: Pierre-Jean G. Malé
name: Bertrand, Joris A. M.
name: Cornuault, Josselin
name: Wakamatsu, Kazumasa
name: Bouchez, Olivier
name: Mould, Claire
name: Bruxaux, Jade
name: Holota, Hélène
name: Milá, Borja
name: Thébaud, Christophe
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60408 Genomics

description: Understanding the mechanisms responsible for phenotypic diversification within and among species ultimately rests with linking naturally occurring mutations to functionally and ecologically significant traits. Colour polymorphisms are of great interest in this context because discrete colour patterns within a population are often controlled by just a few genes in a common environment. We investigated how and why phenotypic diversity arose and persists in the Zosterops borbonicus white-eye of Reunion (Mascarene archipelago), a colour polymorphic songbird in which all highland populations contain individuals belonging to either a brown or a grey plumage morph. Using extensive phenotypic and genomic data, we demonstrate that this melanin-based colour polymorphism is controlled by a single locus on chromosome 1 with two large-effect alleles, which was not previously described as affecting hair or feather colour. Differences between colour morphs appear to rely upon complex cis-regulatory variation that either prevents the synthesis of pheomelanin in grey feathers, or increases its production in brown ones. We used coalescent analyses to show that, from a ‘brown’ ancestral population, the dominant ‘grey’ allele spread quickly once it arose from a new mutation. Since colour morphs are always found in mixture, this implies that the selected allele does not go to fixation, but instead reaches an intermediate frequency, as would be expected under balancing selection.
Appendix I – climate variables and correlations from February precipitation in the wintering grounds of the Lesser Whitethroat, Sylvia curruca: is it a cue for migration onset?
Creators: name: Aloni, Irith
name: Markman, Shai
name: Ziv, Yaron
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Numerous studies report shifts in bird migration phenology, presumably due to global warming. However, most studies focus on migration patterns in the Northern Hemisphere. In this study, we investigated associations between weather conditions in African wintering grounds of the Lesser Whitethroat, Sylvia curruca, and spring arrival time in Eilat, Israel. Using multivariate regression models, we analysed a 30-year dataset in order to examine correlations between median springtime arrival and 46 climate variables of the wintering quarters. The model obtained exhibited a highly statistical fit, involving mean precipitation in February and March with negative effects and number of wet days during November–February. February precipitation levels were also the major factor associated with the interquartile range of arrival time. Interestingly and contrary to published results, annual or seasonal precipitation showed no correlation with spring arrival time, nor did temperature. Moreover, winter in this region falls into dry season with negligible rainfall quantities. Hence, it is unlikely that precipitation effect on habitat productivity is a driving force of migration, as suggested by other studies. Instead, we propose that precipitation in February acts as a cue for the birds, indicating the approach of spring and migration time.
Rapid Clinical Microbiology for Antibiomicrobial Stewardship
Creators: name: Emonet, Stéphane
Publisher: name: Université de Genève
Year: 2019
Subjects: info:eu-repo/classification/ddc/616

description: The tremendous development of Medicine with the advent of transplants, chemotherapies and immunotherapies has made our patient population more vulnerable to infections. For a long time, we could treat them with broad spectrum antimicrobials without the risk of “missing the target”, and adapt our treatment to the results of the microbiological analysis, when it was finally available. This approach has come and gone. The emergence and rapid dissemination of multidrug resistant (MDR) pathogens parallel to the difficulties encountered to provide new antimicrobials, has led today's clinicians in a difficult situation. They need to limit their usage of large spectrum antibiotics, despite being confronted to a higher risk of MDR pathogen. Antimicrobial stewardship (AMS) programs have been intensively developed during the last decades in hospitals, in an attempt to spare our “last-resource” antimicrobials and avoid the continuous spread of MDR bacteria. Microbiology has continually improved by providing clinicians with an accurate diagnosis of the pathogen and its susceptibility to antimicrobials. However, the long delay between sampling and results has limited its ability to influence the choice of antimicrobial in the first week, an unacceptable situation for AMS. Several revolutions took place in our microbiology labs in recent decades with the advent of mass spectrometry and automated bacterial and viral DNA detection systems that have significantly reduced the “time to results”. The line of research described in this thesis reflects a ongoing attempt to improve the “lead time” in our lab, by evaluating some of these new rapid diagnostic tests for their accuracy, reliability and potential impact on patient care. Those tests that convinced us based on these criteria were finally introduced inside our laboratory.
Movie S1 Underwater video of free-ranging pearly razorfish, Xyrithchys novacula in the waters of Mallorca Island from Repeatability of circadian behavioural variation revealed in free-ranging marine fish
Creators: name: Alós, Josep
name: Martorell, Martina
name: Campos-Candela, Andrea
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Repeatable between-individual differences in the behavioural manifestation of underlying circadian rhythms determine chronotypes in humans and terrestrial animals. Here, we have repeatedly measured three circadian behaviours, awakening time, rest onset related and rest duration in the free-ranging pearly razorfish, Xyrithchys novacula, facilitated by acoustic tracking technology and Hidden Markov Models. In addition, daily travelled distance, a standard measure of daily activity as fish personality trait, was repeatedly assessed using a State-Space Model. We have decomposed the variance of these four behavioural traits using linear mixed models and estimated repeatability scores (R) while controlling for environmental co-variates: year of experimentation, spatial location of the activity, fish size and gender and their interactions. Between- and within-individual variance decomposition revealed significant Rs in all traits suggesting high predictability of individual circadian behavioural variation and the existence of chronotypes. The decomposition of the correlations among chronotypes and the personality trait studied here into between- and within-individual correlations did not reveal any significant correlation at between-individual level. We therefore propose circadian behavioural variation as independent axis of the fish personality and the study of chronotypes and their consequences as a novel dimension understanding within-species fish behavioural diversity.
Additional file 2: of Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1â 1 plasmid
Creators: name: Yao, Yuan
name: Enkhtsetseg, Sukhbold
name: Odsbu, Ingvild
name: Fan, Lifei
name: Morigen, Morigen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Plant Biology
subject: Computational Biology

description: Figure S2. The concentrations of ampicillin do not affect chromosomal replication pattern. (DOCX 75 kb)
The Art of MR. Staging the Connectome 7T.
Creators: name: Heuer, Katja
name: Böttger, Joachim
name: Schurade, Ralph
Publisher: name: Zenodo
Year: 2014
Subjects: interactive installation
neuroanatomy
neuroimaging
fiber tracts
diffusion weighted imaging
data visualization
brain
art
sci-art

description: An interactive visualization of brain data. This interactive installation uses high resolution state-of-the-art data derived from a magnetic resonance imaging system at a field strength of 7 Tesla. The diffusion MR data are presented in a dark cube with the help of five projectors showing the according slices on the walls that surround the user in a very direct coupling of user movement and slice transition—it feels like walking through your own brain: The coronal slice on the wall opposite of the entrance; the sagittal slices at the walls to your left and right, respectively; and the axial slices on ceiling and floor. An Xbox Kinect tracks the position of your head inside the cube and according to its position in the room the corresponding slices are shown. In this visualization format you can explore neuroscientific data in a very beautiful and intuitive way—the proportions of the brain are respected and directly translate into the virtual brain space of approximately 3.5 by 2.5 by 2.5 meters.
 You can watch a video of the interactive installation here: https://www.youtube.com/watch?v=oSXcDVgwY8w

 For more detailed information please see the `_details.pdf` file.
Additional file 3: of Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1â 1 plasmid
Creators: name: Yao, Yuan
name: Enkhtsetseg, Sukhbold
name: Odsbu, Ingvild
name: Fan, Lifei
name: Morigen, Morigen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Table S1. The concentrations of ampicillin do not affect the cell-cycle parameters. (DOCX 14 kb)
Appendix I – Climate variables (46 variables: name, description, correlations with median and IQR of arrival day) from February precipitation in the wintering grounds of the Lesser Whitethroat, Sylvia curruca: is it a cue for migration onset?
Creators: name: Aloni, Irith
name: Markman, Shai
name: Ziv, Yaron
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Numerous studies report shifts in bird migration phenology, presumably due to global warming. However, most studies focus on migration patterns in the Northern Hemisphere. In this study, we investigated associations between weather conditions in African wintering grounds of the Lesser Whitethroat, Sylvia curruca, and spring arrival time in Eilat, Israel. Using multivariate regression models, we analysed a 30-year dataset in order to examine correlations between median springtime arrival and 46 climate variables of the wintering quarters. The model obtained exhibited a highly statistical fit, involving mean precipitation in February and March with negative effects and number of wet days during November–February. February precipitation levels were also the major factor associated with the interquartile range of arrival time. Interestingly and contrary to published results, annual or seasonal precipitation showed no correlation with spring arrival time, nor did temperature. Moreover, winter in this region falls into dry season with negligible rainfall quantities. Hence, it is unlikely that precipitation effect on habitat productivity is a driving force of migration, as suggested by other studies. Instead, we propose that precipitation in February acts as a cue for the birds, indicating the approach of spring and migration time.
Brachial-ankle PWV for predicting clinical outcomes in patients with acute stroke
Creators: name: Ahn, Kye Taek
name: Jeong, Jin-Ok
name: Seon-Ah Jin
name: Mijoo Kim
name: Oh, Jin Kyung
name: Ung-Lim Choi
name: Seok-Woo Seong
name: Kim, Jun Hyung
name: Choi, Si Wan
name: Jeong, Hye Seon
name: Song, Hee-Jung
name: Jei Kim
name: In-Whan Seong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Hematology
subject: 60506 Virology
subject: Computational Biology

description: Background: Although brachial-ankle pulse wave velocity (baPWV) is well-known for predicting the cardiovascular mortality and morbidity, its anticipated value is not demonstrated well concerning acute stroke. Methods: Total 1557 patients with acute stroke who performed baPWV were enrolled. We evaluated the prognostic value of baPWV predicting all-cause death and vascular death in patients with acute stroke Results: Highest quartile of baPWV was ≥23.64 m/s. All-caused deaths (including vascular death; 71) were 109 patients during follow-up periods (median 905 days). Multivariate Cox regression analysis revealed that patients with the highest quartile of baPWV had higher risk for vascular death when they are compared with patients with all other three quartiles of baPWV (Hazard ratio with 95% confidence interval [CI] 1.879 [1.022–3.456], p = .042 for vascular death). Conclusion: High baPWV was a strong prognostic value of vascular death in patients with acute stroke
Additional file 1: of Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis
Creators: name: Chen, Xuelian
name: Zhang, Lirong
name: Jiang, Yujie
name: Song, Lian
name: Liu, Yanfang
name: Cheng, Fang
name: Fan, Xin
name: Cao, Xiongfeng
name: Gong, Aihua
name: Wang, Dongqing
name: Zhu, Haitao
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Figure S1. Irradiation-induced fibroblast cell death promotes cancer-cell metastasis in vitro. (PDF 131Â kb)
Multidimensional restitution of the vestibular function with a vestibular implant
Creators: name: Guinand, Nils
Publisher: name: Université de Genève
Year: 2019
Subjects: info:eu-repo/classification/ddc/616.8
Vestibular Implant
Bilateral vestibulopathy

description: Bilateral loss of the vestibular (BV) function leads to chronic imbalance and oscillopsia. This condition has a significant negative impact on quality of life, indicating a need to remedy the lack of effective treatment. The concept of the vestibular implant (VI) has emerged, it consists of a modified cochlear implant stimulator with one up to three additional electrodes positioned in contact with the vestibular nerve. An external processor, fed with motion information captured by a head-fixed motion sensor, is connected to the implanted stimulator. Finally motion modulated electrical stimulation is delivered to the vestibular nerve. Up to now, 13 patients with a BV loss have been implanted. We demonstrated that it is possible to significantly improve or in certain cases to normalize the vestibulo-ocular reflex (VOR) gains. We further showed that the vestibulo-collic reflex could be elicited and that controlled postural responses could be obtained. Finally, the dynamic visual acuity (DVA) while walking has been significantly improved, or even normalized, in 6 subjects. This was the first demonstration of a functional rehabilitation. The presented results reflect the potential of the VI towards a clinically useful device. Moreover, by providing selective stimulations of the vestibular system, the VI opens doors to push the vestibular research beyond the traditional boundaries.
A Class of Isochronous and Non-Isochronous Nonlinear Oscillators
Creators: name: Parkavi, J. Ramya
name: Mohanasubha, R.
name: Chandrasekar, V. K.
name: Senthilvelan, M.
name: Lakshmanan, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: In this work, we present a method of generating a class of nonlinear ordinary differential equations (ODEs), representing the dynamics of appropriate nonlinear oscillators, that have the characteristics of either amplitude independent frequency of oscillations or amplitude dependent frequency of oscillations from the integrals of the simple harmonic oscillator equation. To achieve this, we consider the case where the integrals are in the same form both for the linear and the nonlinear oscillators in either of the cases. We also discuss the method of deriving the associated integrals and the general solution in harmonic form for both the types. We demonstrate the applicability of this method up to 2N coupled first order nonlinear ODEs in both the cases. Further, we illustrate the theory with an example in each case.
description: 19 pages, 3 figures, Accepted for publication in Eur. Phys. J. Spec. Top
Antipsychotic drugs and eating behaviours: Weight gain and metabolic consequences
Creators: name: Sentissi El Idrissi, Othman
Publisher: name: Université de Genève
Year: 2019
Subjects: info:eu-repo/classification/ddc/616.89
Eating behaviour
Food intake
Antipsychotic agents
Second-generation antipsychotics
Weight gain
Metabolic disturbances.

description: Objective: To explore changes in eating behaviours, inherent weight gain and the metabolic consequences in severely mentally ill patients treated with antipsychotic medications. Method: We conducted a comprehensive review of studies that investigated eating behaviours in mentally ill patients taking antipsychotic treatments. We included records that considered weight change and/or varying degrees of adverse metabolic effects and related metabolic disturbances, such as obesity, dyslipidaemia, type 2 diabetes mellitus, hypertension, metabolic syndrome and cardiovascular diseases. We adopted a systematic approache (PRISMA) and considered 4 electronic databases: PubMed, Medline, Embase, and Psychinfo. Moreover, we conducted a manual synthesis of the bibliographies of the identified articles. Results: We identified 29 full-text human studies that investigated the relationship between antipsychotic drugs and changes in eating behaviours resulting in weight gain and other metabolic complications. Twenty-one of the 29 studies demonstrated the emergence of at least one mechanism of disturbed eating behaviour underlying the weight-promoting effects of antipsychotic medication, whereas six studies reported no impact. Conclusion: Despite the limitations of this review, we can conclude that second-generation antipsychotic (SGA) treatment plays a significant role in the weight gain of patients affected by serious mental disorders because these drugs can lead to abnormal appetite, excessive food intake, and cognitive disinhibition, resulting in high morbidity and mortality. The interest in evaluating eating and feeding behaviours in severely mentally ill patients taking psychotropic drugs is still nascent, and studies in the field are scarce and heterogeneous. Future studies should include long-term, double-blind randomized controlled trials with a large sample size and comparable data for several antipsychotics as well as standardized and validated tools to measure eating behaviours.
The role of the gynecologist in enhancing positive adolescent sexuality: integrating prevention into clinical practice
Creators: name: Yaron, Michal
Publisher: name: Université de Genève
Year: 2019
Subjects: info:eu-repo/classification/ddc/618
Adolescent sexuality
Prevention
Positive sexuality
Human Papilloma virus
Contraception
Polycystic ovary syndrome
Intrauterine device
Chalmydia trachomatis

description: In this thesis, I will discuss how focusing on prevention (primordial, primary, secondary, or tertiary) as a pediatric and adolescent gynecologist can be influential and empowering for adolescents and their families, as well as for healthcare providers. I will present topics that reflect my own research and that exemplify the challenges encountered when working at different levels of prevention. In addition I will describe how prevention at all levels can be readily incorporated into pediatric and adolescent gynecological clinical encounters. In addition, I will illustrate how prevention can be achieved through encouraging self-esteem, including positive sexuality, whether in screening or during the management of different conditions.
Additional file 4: of Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1â 1 plasmid
Creators: name: Yao, Yuan
name: Enkhtsetseg, Sukhbold
name: Odsbu, Ingvild
name: Fan, Lifei
name: Morigen, Morigen
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Virology
subject: Computational Biology

description: Table S2. The concentrations of ampicillin do not affect the average number of origin per cell. (DOCX 15 kb)
Active and Passive Collection of SSH key material for cyber threat intelligence
Creators: name: Dulaunoy, Alexandre
name: Huynen, Jean-Louis
name: Thirion, Aurelien
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cryptography and Security (cs.CR)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper describes a system for storing historical forensic artefacts collected from SSH connections. This system exposes a REST API in a similar fashion as passive DNS databases, malware hash registries, and SSL notaries with the goal of supporting incident investigations and monitoring of infrastructure.
MOESM1 of Decreased macrophage inflammatory protein (MIP)-1Îą and MIP-1Î˛ increase the risk of developing nasopharyngeal carcinoma
Creators: name: Yang, Meng-Jie
name: Guo, Jie
name: Ye, Yan-Fang
name: Chen, Sui-Hong
name: Peng, Li-Xia
name: Lin, Chu-Yang
name: Hu, Ting
name: Xie, Shang-Hang
name: Xie, Chuan-Bo
name: Huang, Qi-Hong
name: Lu, Yu-Qiang
name: Liu, Qing
name: Qian, Chao-Nan
name: Cao, Su-Mei
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Additional file 1: Table S1. Performance characteristics of measurement for 33 inflammation markers.