cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the missing heritability for nonsyndromic orofacial clefts in an African population
Creators: name: Alade, Azeez A.
Publisher: name: University of Iowa
Year: 2025
Subjects: Human Genetics
Orofacial Clefts
Pleiotropy
Rare Variants Aggregation Analysis
Replication and Metanalysis
Single Nucleotide Variations
public abstract

description: Nonsyndromic orofacial clefts (NSOFCs) are the most common birth defects affecting the head and neck. These defects have significant medical, psychological, and financial implications. Genetic alterations are important factors contributing to the development of these defects. Previous genetic studies on NSOFCs were largely among individuals of European descent and have led to the identification of over 60 genetic risk loci, explaining 20-30 % of the estimated heritability for NSOFCs. Therefore, to identify the missing heritability, we investigated the genetic causes of NSOFCs in an African population - the most genetically diverse population.
description: Our study replicated and meta-analyzed suggestive genome-wide significant signals from the first African genome-wide association study on NSOFCs. Through this approach, we identified additional novel genome-wide significant loci (10q24 and 2q22) and replicated some of the previously reported ones (MTHFD1, PTCH1, and 8q24) contributing to the risk of NSOFCs. Pathway-based analysis revealed that cell adhesion and neurogenesis were highly associated with NSOFCs.
description: In addition, we evaluated the contributions of rare genetic variations by analyzing rare coding variants. We identified 18 genes, including both novel and known genes, harboring rare variants associated with NSOFCs. Subsequently, we prioritized 11 genes with robust expression in relevant craniofacial structures during human face development of which five (PRDM16, MASP2, ALKBH8, CENPF, and PDZD8 genes) have been previously implicated in vertebrate craniofacial development and diseases.
description: Furthermore, we checked for genetic overlap between the two major NSOFC phenotypes (NSCL/P and NSCPO) and identified three genetic variations that influence the risk for both phenotypes in opposite directions. Using mouse transcriptomics data, we identified consistently expressed and enriched genes in relevant craniofacial structures within the same TAD (1MB) as the variants. Subsequently, we prioritized MDN1, MAP3k7, KMT2A, ARCN1, and VDAC2 genes as top candidates for their potential roles in NSOFCs pathogenesis.
description: Overall, our studies demonstrated the uniqueness of the African population in uncovering novel loci associated with NSOFCs. We replicated some of the previously reported loci and discovered novel loci. Insights from mouse and human transcriptomics data provided valuable evidence underpinning these associations and the plausible mechanisms. Thus, our findings can lay the foundation for novel therapeutic interventions and prevention strategies for NSOFCs.
TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study
Creators: name: Hamann, Lutz
name: Bustami, Jasmin
name: Iakoubov, Leonid
name: Szwed, Malgorzata
name: Mossakowska, Malgorzata
name: Schumann, Ralf R.
name: Puzianowska-Kuznicka, Monika
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Healthy aging
subject: Inflamm-aging
subject: Toll-like receptor 6
subject: Polymorphism
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background To investigate mechanisms that determine healthy aging is of major interest in the modern world marked by longer life expectancies. In addition to lifestyle and environmental factors genetic factors also play an important role in aging phenotypes. The aged immune system is characterized by a chronic micro-inflammation, known as inflamm-aging, that is suspected to trigger the onset of age-related diseases such as cardiovascular disease, Alzheimer’s disease, cancer, and Diabetes Mellitus Type 2 (DMT2). We have recently shown that a Toll-like receptor 6 variant (P249S) is associated with susceptibility to cardiovascular disease and speculated that this variant may also be associated with healthy aging in general by decreasing the process of inflamm- aging. Results Analyzing the PolSenior cohort we show here that nonsmoking S allele carriers are significantly protected from age-related diseases (P = 0.008, OR: 0.654). This association depends not only on the association with cardiovascular diseases (P = 0.018, OR: 0.483) for homozygous S allele carriers, but is also driven by a protection from Diabetes Mellitus type 2 (P = 0.010, OR: 0.486) for S allele carriers. In addition we detect a trend but no significant association of this allele with inflamm-aging in terms of baseline IL-6 levels. Conclusion We confirm our previous finding of the TLR-6 249S variant to be protective regarding cardiovascular diseases. Furthermore, we present first evidence of TLR-6 249S being involved in DMT2 susceptibility and may be in general associated with healthy aging possibly by reducing the process of inflamm-aging.
title: Hidden hands and invisible arms
title: regional accreditor's agency in student success outcomes in small, private, non-selective colleges
titleType: Subtitle
Creators: name: Kinney, Paula M.
Publisher: name: University of Iowa
Year: 2022
Subjects: Accreditation
Non-selective college
student success outcomes
public abstract

description: Poor retention and completion outcomes cast doubts about the ability of higher education to provide a return on the money, time, and resource investment. Accountability for the quality of higher education has been an increasingly significant national issue in higher education over the past decade. As pressures for accountability increase, so does the call for greater oversight. In the United States, the oversight for assuring the performance quality of higher education is accreditation. This study addressed the research problem of how and if a quality assurance process can also be a quality improvement process. Using a phenomenological approach, the study explored how a focus on student success outcomes of retention and graduation has influenced organizational changes for improving student success outcomes in small, private, four-year non-selective colleges. The inclusion of multiple accreditation regions facilitated the exploration of the similarity of changes across one type of college. Through a two-phased approach centered on the accreditor-Department of Education and the accreditor-college relationship, a document analysis and semi-structured interviews examined how the Department of Education instructs accreditors to include certain content to be part of accreditation standards and how accreditors embed Department of Education directives into their own institutional documents to convey the importance student success outcomes to colleges. This phase also explored opportunities accreditors provide to help improve retention and completion. The second phase used semi-structured interviews with Accreditation Liaison Officers at four small, private, non-selective colleges located in four different regions of the United States. An interview with the Accreditation Liaison Officer at each college provided insight about perceptions of the processes and roles of accreditation as they pertained to improving retention and completion outcomes. Overall, the findings suggest that accreditation currently plays a minimal role in improving retention and completion in colleges.
Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL
Creators: name: Fransecky, L.
name: Neumann, M.
name: Heesch, S.
name: Schlee, C.
name: Ortiz-Tanchez, J.
name: Heller, S.
name: Mossner, M.
name: Schwartz, S.
name: Mochmann, L. H.
name: Isaakidis, K.
name: Bastian, L.
name: Kees, U. R.
name: Herold, T.
name: Spiekermann, K.
name: Goekbuget, N.
name: Baldus, C. D.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: GATA3
subject: ETP-ALL
subject: PER-117
subject: Decitabine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: Background GATA3 is pivotal for the development of T lymphocytes. While its effects in later stages of T cell differentiation are well recognized, the role of GATA3 in the generation of early T cell precursors (ETP) has only recently been explored. As aberrant GATA3 mRNA expression has been linked to cancerogenesis, we investigated the role of GATA3 in early T cell precursor acute lymphoblastic leukemia (ETP-ALL). Methods We analyzed GATA3 mRNA expression by RT-PCR (n = 182) in adult patients with T-ALL. Of these, we identified 70 of 182 patients with ETP-ALL by immunophenotyping. DNA methylation was assessed genome wide (Illumina Infinium® HumanMethylation450 BeadChip platform) in 12 patients and GATA3-specifically by pyrosequencing in 70 patients with ETP-ALL. The mutational landscape of ETP-ALL with respect to GATA3 expression was investigated in 18 patients and validated by Sanger sequencing in 65 patients with ETP-ALL. Gene expression profiles (Affymetrix Human genome U133 Plus 2.0) of an independent cohort of adult T-ALL (n = 83) were used to identify ETP-ALL and investigate GATA3low and GATA3high expressing T-ALL patients. In addition, the ETP-ALL cell line PER-117 was investigated for cytotoxicity, apoptosis, GATA3 mRNA expression, DNA methylation, and global gene expression before and after treatment with decitabine. Results In our cohort of 70 ETP-ALL patients, 33 % (23/70) lacked GATA3 expression and were thus defined as GATA3low. DNA methylation analysis revealed a high degree of GATA3 CpG island methylation in GATA3low compared with GATA3high ETP-ALL patients (mean 46 vs. 21 %, p
Correlation of cell-free DNA plasma concentration with severity of non- alcoholic fatty liver disease
Creators: name: Karlas, Thomas
name: Weise, Lara
name: Kuhn, Stephanie
name: Krenzien, Felix
name: Mehdorn, Matthias
name: Petroff, David
name: Linder, Nicolas
name: Pratschke, Johann
name: Wiegand, Johannes
name: Splith, Katrin
name: Schmelzle, Moritz [U.A.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Controlled attenuation parameter
subject: Transient elastography Cell-free DNA
subject: MR-spectroscopy
subject: Non-alcoholic fatty liver disease
subject: Non-alcoholic steatohepatitis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The assessment of fibrosis and inflammatory activity is essential to identify patients with non-alcoholic fatty liver disease (NAFLD) at risk for progressive disease. Serum markers and ultrasound-based methods can replace liver biopsy for fibrosis staging, whereas non-invasive characterization of inflammatory activity remains a clinical challenge. Cell- free DNA (cfDNA) is a novel non-invasive biomarker for assessing cellular inflammation and cell death, which has not been evaluated in NAFLD. Methods Patients and healthy controls from two previous studies were included. NAFLD disease activity and severity were non-invasively characterized by liver stiffness measurement (transient elastography, TE) including steatosis assessment with controlled attenuation parameter (CAP), single-proton magnetic resonance spectroscopy (1H-MRS) for determination of hepatic fat fraction, aminotransferases and serum ferritin. cfDNA levels (90 and 222 bp fragments) were analyzed using quantitative real-time PCR. Results Fifty-eight NAFLD patients (age 62 ± 11 years, BMI 28.2 ± 3.5 kg/m2) and 13 healthy controls (age 38 ± 12 years, BMI 22.4 ± 2.1 kg/m2) were included. 90 bp cfDNA levels were significantly higher in NAFLD patients compared to healthy controls: 3.7 (1.3–23.1) vs. 2.9 (1.4–4.1) ng/mL (p = 0.014). In the NAFLD cohort, circulating cfDNA correlated significantly with disease activity and severity, especially in patients with elevated liver stiffness (n = 13, 22%) compared to cases with TE values ≤7 kPa: cf90 bp 6.05 (2.41–23.13) vs. 3.16 (1.29–7.31) ng/mL (p < 0.001), and cf222 bp 14.41 (9.27–22.90) vs. 11.32 (6.05–18.28) ng/mL (p = 0.0041). Conclusions Cell-free DNA plasma concentration correlates with established non-invasive markers of NAFLD activity and severity. Therefore, cfDNA should be further evaluated as biomarker for identifying patients at risk for progressive NAFLD.
Analyzing the effect of soil moisture inputs on remotely sensed gross primary production (GPP) estimates in the upper midwest
Creators: name: Mykleby, Eric A.
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract
Environmental Science

description: During drought, low soil moisture, and vapor pressure deficit cause plants to tightly co-regulate water loss and CO2 assimilation. This impacts primary terrestrial ecosystem production, an important indicator for numerous ecosystem functions. As a measure of this productivity, gross primary production (GPP) is highly relevant for estimating agricultural production because it represents the carbon fixed through photosynthesis and is therefore the foundation for the accumulation of crop biomass. However, measuring this productivity in the field can be difficult and expensive. Soil moisture and vapor pressure deficit are the primary water stress drivers that influence vegetation health, but soil moisture has traditionally been difficult to measure, especially at large spatial scales.
description: This study uses light use efficiency (LUE) models that include vapor pressure deficit and soil moisture factors to estimate GPP and investigate how these water stress metrics influence vegetation productivity and model skill. Differences in these models are assessed and compared relative to the specific site biome and how environmental scalar factors behave. Ecosystem production data was used from the Ameriflux network of towers and satellite-based soil moisture measurements from SMAP. We focused on sixteen sites in the upper midwestern United States that encompassed cropland, evergreen needleleaf, and deciduous broadleaf biomes.
description: This study found that incorporating satellite-based soil moisture estimates into an LUE model can improve GPP estimates in some scenarios including mid to late summer period primarily at the cropland sites. Late spring also saw periods where incorporating soil moisture may be beneficial for model accuracy. These findings show that vapor pressure deficit alone may not capture the full impacts of moisture stress on vegetation productivity. Especially in agricultural ecosystems, there are times of the year when soil moisture effects are necessary to capture changes in productivity.
Videogames for independent living: A novel approach to telehealth
Creators: name: Smith, Stuart T.
Publisher: name: Swinburne
Year: 2024

description: In this article we address the health-related barriers to independence of older adults and review the evidence for the use of telehealth technologies to facilitate and promote continued independence. In particular we outline a program of research at Neuroscience Research Australia which aims to (1) design, develop and implement of broadband-enabled videogame technology framework to facilitate independent living in older adults and (2) assess the effectiveness of home-based videogame technologies to impact upon age-related health issues that significantly reduce independence in older adults. We show as an example work we are doing to address the issue of postural instability and falls in older adults.
Orissa Administration VS Productive Education: A Critical Analysis
Creators: name: Dhal, Pravat
Publisher: name: figshare
Year: 2020
Subjects: Education

description: In Orissa, various types of schools had been prevailing. There was a discrimination in education system. The administrations during that moment told that Education was not productive.In that scenario it was written and published in OSSTA Journal."Shiksha Pradeep'.
Multiculturalisme et mythe chez Neil Bissoondath : une analyse sémiologique.
Creators: name: Hamel, Jason.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Canadian Studies.

description: L'objet de cette these est le livre Selling Illusions: The Cult of Multiculturalism in Canada, de Neil Bissoondath. L'hypothese avancee est que ce livre contient un discours reposant sur une mystification en faveur de l'ango-conformisme. Pour corroborer l'hypothese, l'analyse semiologique, telle que definie par Roland Barthes, est employee. Plus precisement, l'analyse porte sur trois themes: la signification de la politique du multiculturalisme, celle d'etre canadien et celle d'etre quebecois. Il en ressort que la signification de la politique du multiculturalisme suppose le mythe de la "ghettoisation ethnique". Elle suppose en outre qu'etre canadien repose sur un conformisme une culture unique et "ouverte", et s'il est normal que l'identite quebecoise implique avant tout le francais, il serait normal que cela soit aussi le cas de l'identite canadienne avec une seule et unique langue: l'anglais.
USO IRRACIONAL DOS MEDICAMENTOS ANTI-INFLAMATÓRIOS NÃO ESTERÓIDES
Creators: name: Carol Farias REZENDE
name: Fernanda Silva ALVES
name: Odeize Viana COSTA
name: Ana Ydelplynya Guimarães AMARO
Publisher: name: Zenodo
Year: 2025

description: RESUMO

 

Os anti-inflamatórios não esteroides (AINES) são amplamente utilizados como analgésicos para tratar dores agudas e crônicas, como aquelas associadas a processos inflamatórios, cirurgias, artrite reumatoide e osteoartrites. Embora sejam eficazes, o uso inadequado é comum, com a OMS alertando que mais de 50% dos medicamentos são prescritos ou vendidos de forma imprópria. Isso se deve, em parte, à falta de informação dos pacientes, que muitas vezes ignoram as orientações médicas sobre posologia e segurança, levando ao uso excessivo. Os AINES atuam inibindo as enzimas ciclooxigenases (COX-1 e COX-2), responsáveis pela produção de prostaglandinas, que estão envolvidas na dor e inflamação. A COX-1 tem funções protetoras no organismo, enquanto a COX-2 está relacionada a processos inflamatórios. O uso indiscriminado pode causar efeitos adversos, como dores e úlceras gastrointestinais, o que torna crucial a orientação médica adequada sobre o uso seguro desses medicamentos.
A Novel Approach to Teaching Women How to Reduce Their Breast Cancer Risk : The Breast Cancer Prevention & Risk Assessment Clinic
Creators: name: Gotay, Carolyn C., 1951-
name: Dawson, Marliese Y.
name: Shen, Hui
name: Ashman, Melissa
name: Mager, Tracey
name: McCoy, Bonnie
Publisher: name: The University of British Columbia
Year: 2017

description: It is estimated that as many as 40% of breast cancers could be prevented by modifying lifestyle risk factors, yet this fact is not well-known in the population. In 2011, the Breast Cancer Prevention & Risk Assessment Clinic launched in BC, providing women with objective risk assessments and evidence-based counseling about how to reduce their risks. Between 2011 and 2016, the Clinic revised its approaches and procedures to maximize potential reach in the province. In 2016, the grant providing financial support for the Clinic ended, and a new cost-recovery model was adopted. This report describes this novel Clinic’s changing service models, activities, and accomplishments.
Понятие «польской нации» в делопроизводственных документах Российской империи 1720-1760-х гг.: на примере римско-католической общины Санкт-Петербурга
Creators: name: Самыловская Екатерина Анатольевна
Publisher: name: Russian Colonial Studies
Year: 2020
Subjects: нация
поляки
«польская нация»
римско-католическая община Санкт-Петербурга
Российская империя

description: Статья посвящена анализу употребления понятия «польской нации» в делопроизводственных документах Российской империи в контексте регулирования взаимоотношений выходцев с «польских» территорий внутри многонациональной петербургской римско-католической общины. В основу лег анализ делопроизводственных документов, представленных в Российском государственном историческом архиве (РГИА) и Архиве внешней политики Российской империи (АВПРИ), а именно: документы Коллегии иностранных дел и Святейшего правительствующего Синода, связанные с регулированием религиозной жизни римских католиков Санкт-Петербурга (донесения и допросы католических священнослужителей, донесения и прошения прихожан и старост общины и пр.). Особое внимание уделено Регламенту 1769 г. («Регламент, данный Санкт-Петербургской Римско-Католической церкви»). Автор приходит к выводу, что несмотря на то, что община сформировалась из иностранцев, прибывших в город из различных регионов Европы, и пополнялась за счет небольшого естественного прироста и приезжих, не стоит считать, что в изученных делопроизводственных документах под понятием «польская нация» обозначалось исключительно только место рождения приехавшего иностранца (т.е. выходца из польских земель). Обращает на себя внимание тот факт, что в документах понятие «нация» применялось еще к трем многочисленным группам римскокатолической общины, а именно к «немцам», «французам» и «итальянцам». При этом отдельно не выделялись «ирландцы», «шотландцы», «хорваты» и прочие, хотя выходцы из данных регионов входили в общину. Представляется, что под этим понятием понималась в первую очередь общность языка, на котором изъяснялись прихожане, а во вторую очередь уже место происхождения.
Beregnete Bauteile und Bauprodukte: Entwicklung von Vergabegrundlagen für den Blauen Engel mit Hilfe von Auslaugtests
Creators: name: Bandow, Nicole
name: Jürgens, Frederike
name: Schoknecht, Ute
Publisher: name: My University
Year: 2018
Subjects: Produktkennzeichnung
Umweltzeichen
Umweltbelastung
Auslaugung
Minderungspotenzial
Bauelement
Produktbewertung
Produktbezogene Umweltdeklaration
Bauprodukt
Bewertungskriterium

description: Auslaugversuche wurden mit verschiedenen Bauprodukten durchgeführt, die unter Anwendungsbedingungen mit Niederschlägen in Kontakt kommen können. In das Testprogramm wurden Lacke für Außenanwendungen, Wärmedämmverbundsysteme, Dachziegel und polymere Dachfolien einbezogen. Mit diesen Produkten wurden der von CEN TC 351 entwickelte dynamische Oberflächenauslaugtest (DSLT) und Immersionstests nach EN 16105 durchgeführt. Emissionsverläufe wurden sowohl für anorganische Komponenten als auch für organische Substanzen in den Eluaten ermittelt. Auslaugbare organische Substanzen wurden zuvor in Screeningtests identifiziert. Um die mögliche Freisetzung von Stoffen aus Bauprodukten beurteilen zu können, ist es erforderlich, Emissionsverläufe zu beschreiben. Dazu sind die verwendeten Testverfahren geeignet. Um Bauprodukte mit einem Blauen Engel als "Produkte mit geringer Auslaugung" auszuloben, müssen die auslaugbaren Substanzen komplett bekannt sein. Für organische Verbindungen ist das noch eine Herausforderung. Außerdem erfordert die Bewertung der Testergebnisse sowohl Übertragungsmodelle, die Vorhersagen über freisetzbare Stoffmengen unter Anwendungsbedingungen ermöglichen, als auch Vorgaben zu tolerierbaren Umweltkonzentrationen. Hier besteht noch Handlungsbedarf. Quelle: Forschungsbericht
description: Leaching tests were performed on different construction products that can be exposed to precipitation during service life. Varnishes for outdoor application, exterior thermal insulation systems, roof tiles and polymeric roof membranes were included in the test program. Leaching tests according to the dynamic surface leaching test (DSLT) as developed by CEN TC 351 and the immersion test according to EN 16105 were performed using these products. Emission curves were determined for inorganic as well as organic substances in the eluates. Leachable organic substances in the eluates were identified by screening tests prior to the leaching tests. It is necessary to describe emission curves to be able to evaluate possible release of substances from construction products. The applied leaching tests are suitable to describe leaching processes. All leachable substances need to be known in order to award the ecolabel Blue Angel. This is still challenging in case of organic substances. In addition, evaluation of the test results requires transfer models to predict leachable amounts under service conditions as well as requirements on concentrations that can be tolerated in environmental compartments. There is still need for action to solve these topics. Quelle: Forschungsbericht
Checklist: Minimum Criteria for the Reuse of Research Data
Creators: name: Asfar, Amira
name: Daudrich, Anna
name: Hauf, Nicolai
name: Šimukovič, Elena
name: van Rekum, Simon
Publisher: name: Zenodo
Year: 2024
Subjects: FAIR
Checklist
Research Data
Research Data Management
Data Reuse

description: This checklist serves as a guide when initiating a project that uses existing research data, such as survey results, statistics, measured values, or image and video data from other studies. This may be the case for a scientific paper or a student assignment, for example. The checklist is aimed at both supervisors and individuals who directly reuse data. It includes general steps, the minimum criteria to be fulfilled, and additional information.
The media unconscious of confessional poetry
Creators: name: Lowenthal, Jeremy
Publisher: name: University of Iowa
Year: 2025
Subjects: Confessional poetry
Sound media
public abstract
Trauma

description: This dissertation attends to the technological underpinnings of the confessional poetry genre in postwar sound recording, augmentation, and reproduction practices. Sounding out, recording, and airing their traumatic experiences — both personal and collective, confessional poets configured new autobiographical lyric sound structures pursuant with the aesthetic allowances of their rapidly globalizing sound media infrastructure. Their confessional poetry’s psycho-acoustics afforded unprecedented access to the interior of the traumatic experience, the audibility of which solicited new modes of listening to the innerworkings of the unconscious and its traumatic machinations. Hence the “media unconscious of confessional poetry,” a phrase used herein to designate the basis of confessional conceptualizations of the unconscious in analog sound and broadcast technologies.
description: The sound media underwriting the unconscious across the confessional poetry genre challenge trauma studies’ continued privileging of the traumatic image and the visual witness, which mutes and marginalizes the sound-saturated forms of traumatic expression that circulated the global media ecology during the postwar period. To formulate an ear-sighted hermeneutics more attentive to the sound of trauma, this dissertation draws from a sampling of circum-Atlantic confessional poems, pursuing the genre beyond the problematic national, cultural, and racial lines that have heretofore defined it. I argue that intercultural media practices like recording and broadcasting and corresponding traumatosonic poetic features account for the genre’s coherence instead, unifying various forms of confessional poetry across continents, cultures, and diverse intersectional identities.
Weiterentwicklung der rechtlichen Regelungen zum Schutz vor Fluglärm
Creators: name: Schütte, Silvia
name: Arps, Henning
name: Brohmann, Bettina
Publisher: name: My University
Year: 2018
Subjects: subject: Fluglärm
subject: Aktiver Schallschutz
subject: Lärmschutzbereich
subject: Flugplatz
subject: Flughafen
subject: Lärmwirkung
subject: Flugtechnik
subject: Luftverkehr
subject: passiver Schallschutz
subject: Fluglärmgesetz
subject: Flugverfahren
subject: Lärmwirkungsforschung
subject: Luftfahrttechnik
subject: Luftverkehrsgesetz
subject: Fluglärmschutzverordnung
subject: Lärm

description: Im Jahre 2007 wurde das Gesetz zum Schutz gegen Fluglärm (FluLärmG) novelliert. Nach 10 Jahren soll nun die Bundesregierung einen Bericht zur Evaluierung dieses Gesetzes vorlegen. Dieses Gutachten diente der Vorbereitung dieses Berichts sowie des diesbezüglichen Fluglärmberichts 2017 des Umweltbundesamtes. Hierfür wurden insbesondere der Sachstand des Gesetzesvollzuges sowie Erfahrungen, Einschätzungen und Veränderungsvorschläge der relevanten Akteure zum FluLärmG ermittelt. Zudem wurden neue Erkenntnisse zur Lärmminderung an der Quelle in der Luftfahrt und in der Lärmwirkungsforschung analysiert, um insbesondere die Schallpegelwerte zu bewerten, ab denen Maßnahmen nach dem FluLärmG greifen.
Talking about terrorism: An analysis of official Canadian insecurity narratives in the post-September 11 context
Creators: name: Larsen, Mike
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Political Science, Public Administration.
subject: Sociology, Criminology and Penology.

description: This study identifies the dominant characteristics of official Canadian state discourses on national security and terrorism in the post-September 11 context, using a content analysis methodology; identifies key themes and/or areas of incongruity in these discourses, and relates these findings to a broader discussion of contemporary Canadian national security policy and practice. Major themes of interest and key terms are identified through a review of the literature, and used as the basis for an analysis of twenty (20) samples of open-source official (federal government) Canadian discourse from the post-September 11 context. It is argued that state discourses about terrorism and security are a core component of national security campaigns, and that through the construction of insecurity narratives (constellations of discourse about a particular security threat), states effectively 'do national security '. The study finds that the current Canadian insecurity narrative is characterized by themes of exceptionality, urgency, necessity, secrecy, and crisis---and consistent references to September 11 as a mobilizing event. The nature of this narrative is such that the current national security campaign is indeterminate in length, ambiguous in purpose, and expansionary in trajectory.
UBC®Rapid Test for detection of carcinoma in situ for bladder cancer
Creators: name: Ecke, Thorsten H.
name: Weiss, Sarah
name: Stephan, Carsten
name: Hallmann, Steffen
name: Barski, Dimitri
name: Otto, Thomas
name: Gerullis, Holger
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: UBC®Rapid Test
subject: bladder cancer
subject: carcinoma in situ
subject: urinary tumor marker
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten

description: UBC®Rapid Test is a test that detects fragments of cytokeratins 8 and 18 in urine. We present results of a multicentre study measuring UBC®Rapid Test in bladder cancer patients and healthy controls with focus on carcinoma in situ (CIS) and high-grade bladder cancer. From our study with N = 452 patients, we made a stratified sub-analysis for carcinoma in situ of the urinary bladder. Clinical urine samples were used from 87 patients with tumours of the urinary bladder (23 carcinoma in situ, 23 non-muscle-invasive low-grade tumours, 21 non-muscle-invasive high-grade tumours and 20 muscle-invasive high-grade tumours) and from 22 healthy controls. The cut-off value was defined at 10.0 µg/L. Urine samples were analysed by the UBC®Rapid Test point-of-care system (concile Omega 100 POC reader). Pathological levels of UBC Rapid Test in urine are higher in patients with bladder cancer in comparison to the control group (p < 0.001). Sensitivity was calculated at 86.9% for carcinoma in situ, 30.4% for non-muscle-invasive low-grade bladder cancer, 71.4% for nonmuscle-invasive high grade bladder cancer and 60% for muscle-invasive high-grade bladder cancer, and specificity was 90.9%. The area under the curve of the quantitative UBC®Rapid Test using the optimal threshold obtained by receiveroperated curve analysis was 0.75. Pathological values of UBC®Rapid Test in urine are higher in patients with high-grade bladder cancer in comparison to low-grade tumours and the healthy control group. UBC®Rapid Test has potential to be more sensitive and specific urinary protein biomarker for accurate detection of high-grade patients and could be added especially in the diagnostics for carcinoma in situ and non-muscle-invasive high-grade tumours of urinary bladder cancer.
Example-based natural three-dimensional expression generation for virtual human faces
Creators: name: Zhu, Lijia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: This thesis proposes a methodology which produces natural facial expressions for 3D human face models by making use of a databank. Firstly, guided by the specified feature point motions, an approach is introduced for generating facial expressions by blending the examples in an expression databank. The optimized blending weights are obtained implicitly by Genetic Algorithms (GA). Secondly, a consistent parameterization technique is shown to model the desired structured human face by processing the raw laser-scanned face data. Based on this technique, we construct a facial motion databank consisting of consistent facial meshes. Thirdly, rather than producing novel facial expressions for a different subject from scratch, an efficient method is presented to retarget facial motions from one person to another. Finally, these techniques are combined together to reconstruct the 3D facial motions (surface motions) based on the motion capture data (feature point motions).
Политическая стратегия Екатерины II в символике придворных праздников
Creators: name: Новикова Арина Дмитриевна
Publisher: name: Russian Colonial Studies
Year: 2020
Subjects: политическая имагология
просвещенный абсолютизм
придворные праздники
культура России
Екатерина II

description: В статье на основе неопубликованных документов из Российского государственного архива древних актов (РГАДА), периодики, воспоминаний современников и других источников исследуется символика придворных праздников Екатерины II. Автор статьи приходит к выводу, что торжества были частью политической стратегии императрицы, и их риторика менялась в зависимости от «целевой аудитории». Высокоторжественные дни, празднование которых выносилось на общеимперский уровень, были призваны легитимировать власть Екатерины в глазах подданных, а придворные маскарады, на которых присутствовали члены европейских королевских семей, служили внешнеполитическому курсу. Таким образом, основные идеи царствования Екатерины II зашифровывались в сценариях праздничных торжеств и были частью стратегии репрезентации фигуры просвещённой монархини. Представленное исследование – первая в историографии попытка анализа придворных праздничных церемониалов в политическом ключе. Предложенные автором подходы позволяют углубить знания о природе неограниченной власти и стратегий политиков.
К истории гимназии Э.П. Шаффе
Creators: name: Пилосян Маринэ Каровна
Publisher: name: Russian Colonial Studies
Year: 2020
Subjects: «Дом образования»
Шаффе
Российская империя
Санкт-Петербург
женское образование
гимназия Карла Мая

description: К вопросу становления женского образования в России сейчас обращаются многие исследователи. В Петербурге во второй половине XIX века было открыто множество женских учебных заведений как частных, так и государственных. В статье идет речь о частной женской гимназии Эмилии Павловны Шаффе (1858-1917). Статья основана на архивных материалах Центрального Государственного Исторического архива Санкт-Петербурга. Автором анализируются дела, связанные с ученицами гимназии, преподавателями и учебной программой. Хронологические рамки исследования содержат период с 1882 по 1918 гг., однако акцент сделан на 1900-1918 гг. Территориальные рамки – дореволюционный Петербург – столица гимназического образования Российской империи. Помимо архивных документов использованы достижения современной историографии. В ходе исследования автор приходит к выводу, что учебная программа была очень насыщенной, а большинство предметов были гуманитарного цикла (история русской словесности и пр.). Количество учениц было небольшим, все они жили в шаговой доступности от учебного заведения. У школы существовали свои традиции – ежегодные ярмарки, на которых продавались предметы собственного производства. Все собранные средства направлялись в фонд помощи ученицам и преподавательницам. Несмотря на то, что гимназия была лингвистической с упором на немецкий и французские языки, со временем выпускниц-иностранок было все меньше и меньше. Подобное случилось и с преподавателями.
Telehealth in general practice
Creators: name: Szucs, Craig
Publisher: name: Swinburne
Year: 2024

description: General Practice is a highly computerised part of the health system and the place where most Australians receive health care. This positions it well to lead the adoption of telehealth. On the other hand, by supporting computerisation in general practice to a greater extent than in other health sectors, we may have created an island of computerisation in a sea of paper. Because this island is essentially a collection of thousands of independent small businesses, the adoption of new systems is especially challenging. Each general practice can choose to participate or to not. This article discusses the adoption of technology in the sector so far, and examines what will be required to ensure that the current investment in telehealth succeeds.
The method in the madness: themes and conventions in Shakespeare's portrayal of madness
Creators: name: Lopos, George John
Publisher: name: University of Iowa
Year: 1979
Subjects: Mental illness in literature
Shakespear, William, 1564-1616
English drama
Dramatic or Theatre Arts

description: This thesis examines the portrayal of madness in six of Shakespeare's plays: The Comedy of Errors, A Midsummer Night's Dream, Twelfth Night, Hamlet, Othello, and Lear.
К вопросу о Советской власти в Баку (1917 - лето 1918 гг.)
Creators: name: Лобанов Владимир Борисович
name: Ализаде Джавид Ильгар оглы
Publisher: name: Russian Colonial Studies
Year: 2020
Subjects: Закавказье
Баку
Тбилиси
Октябрьская революция
Азербайджан
большевики
меньшевики

description: В статье затрагиваются основные причины того, почему Закавказье, в особенности такие центры как Баку и Тифлис, стало оплотом двух противоборствующих фракций социал-демократов (большевиков и меньшевиков) после октября 1917 года. Актуальность исследования обусловлена тем, что на протяжении длительного периода времени борьба этих фракций оказывала определяющее влияние на развитие политической ситуации в регионе. Делается попытка выяснить причины советизации Баку, а также ответить на вопрос, почему этот город стал единственным местом в регионе, где после прихода большевиков к власти в Петрограде смогла установиться Советская власть. Уделяется внимание тому, как у новой власти складывались отношения с местными политическими силами, на кого она могла опереться, а главное – в чем была причина выбора той или иной силы в союзники. Наконец, рассматривается вопрос о том, какие действия Советской власти привели к тактическому поражению и стали причиной ее падения летом 1918 года. Выше обозначенные проблемы рассмотрены на фоне не только политической обстановки в Закавказье, но и на фоне продолжавшейся на тот момент Первой Мировой войны. Данное исследование опирается на широкий круг источников, включая опубликованные декреты и договоры, мемуары непосредственных участников событий, а также новейшие достижения историографии по данной проблематике. Статус Баку как промышленного центра и высокая доля пролетариата в населении города стали одной из главных причин прихода большевиков к власти. Однако они оказались не в силах снять противоречия, доставшейся в наследство от Царской России. Опора на национальные меньшинства, а также жесткая политика по установлению Советской власти в регионе, в конечном счете, привели к усилению антибольшевистских сил и к свержению власти Совнаркома в Баку.
Продовольственное обеспечение Ленинграда в эпоху перестройки
Creators: name: Полынов Матвей Фёдорович
name: Халимочкин Владимир Сергеевич
Publisher: name: Russian Colonial Studies
Year: 2020
Subjects: перестройка
продовольствие
Ленинград
карточная система
дефицит
талоны
Ленсовет
Санкт-Петербург

description: Продовольственная проблема в годы перестройки была одной из основных и самых болезненных. Продовольственная картина конца 1980-х – начала 1990-х гг. является важнейшей составляющей описания быта и повседневности ленинградцев того времени. Кроме того, проблема снабжения населения продуктами питания во многом предопределила политические процессы перестройки в Ленинграде, была одной из важнейших причин утраты доверия к Коммунистической партии, перехода власти к «демократам», избранным в руководство Ленсовета, а впоследствии падения и их рейтинга в глазах граждан. В исследовательской литературе тема продовольственной политики страны и отдельных регионов исследована недостаточно. В данной статье авторы рассмотрели проблему продовольственного обеспечения Ленинграда в эпоху перестройки, а также социально-экономические и политические последствия, которые данная проблема за собой повлекла.
Religion and nationalism in Quebec: The Saint-Jean-Baptiste celebrations in sociological perspective.
Creators: name: Boisvert, Donald Luc.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Religion, General.

description: This thesis is a sociological study of la Fete de la Saint-Jean-Baptiste in Quebec, from its beginnings until the present. It argues that la Fete was a stage for the express-sion and unification of three sets of polarities found within Quebec society: nationalism vs. religion, the elite vs. the masses, and popular religiosity vs. clerical authority. Its five chapters can be divided into three general parts: the historical (Chapters I, II and III), the theoretical (Chapter IV) and the analytical (Chapter V). The Introduction, in addition to summarizing the contents of the thesis, briefly discusses some major theoretical contributions to the sociology of religion and the rapport between religion and the feast. Chapter I is a review of the relationship between the Catholic Church and Quebec society. This is meant to provide the basic foundation for subsequent analyses. The history of Quebec Catholicism is considered in terms of the customary breakdown: New France, post-Conquest, ultramontanism and the Quiet Revolution. Particular attention is paid, in this chapter, to the manner in which the Church had an impact upon structures of belief, both religious and secular. The next two chapters deal specifically with the celebrations and the group with which they are most often associated. Chapter II discusses la Fete itself, both in terms of its history and its symbolic and ritualistic components. The celebrations are analyzed on the basis of three historical periods: the Patriotes, ultramontanism or the period of clerical domination, and the Quiet Revolution and its aftermath. Chapter III takes a look at the Societe Saint-Jean-Baptiste de Montreal, not so much in terms of its detailed history as its ideological profile and influence. Chapter IV concentrates on examining the central theoretical concepts which run throughout the thesis: nationalism, ideology, class, secularization and popular religion. In the last two sections of this chapter, a sociological perspective on the notion of the feast is suggested, and the three sets of polarities are introduced. The concluding chapter, Chapter V, attempts a systematic analysis of the polarities, as these were reflected during each of the three historical periods associated with la Fete. There is a brief discussion of rituals in the opening pages. The formal Conclusion to the thesis summarizes the central arguments, in the context of some of the themes introduced earlier. An appendix discusses three topics in greater detail: participation rates in the public gatherings, other associations spawned by the Societe, and membership figures.
Resilient Coast : Liquid Fuel Delivery to British Columbia Coastal Communities
Creators: name: Tanner, Alexa
name: Dowlatabadi, Hadi
name: Chang, Stephanie
name: Da Costa, Rodrigo
name: Shen, Xuesi
name: Brown, Allanah
Publisher: name: The University of British Columbia
Year: 2017

description: Coastal and island communities in British Columbia (BC) are highly dependent on maritime transportation to support their basic needs, such as fuel deliveries. Historically, coastal communities maintained substantial local caches of supplies; however, with the advance of integrated supply chains and more frequent scheduled maritime service, just-in-time delivery has become the norm for providers such as supermarket chains, acute healthcare facilities, and fuel suppliers. Thus, coastal communities will experience shortages of critical supplies any time regular maritime service is disrupted beyond the level that can be met using local caches. In a disruption, fuel is a critical commodity that is required not only by the public in general, but also for emergency response vehicles and facilities. Emergency management and planning for community resilience to disruptions therefore requires an understanding of how fuel is supplied and flows in the region. The region has had comparatively little direct experience with fuel supply chain disruptions and shortages. Publicly available information on the fuel system in BC is highly fragmented, inconsistent, and incomplete, thus posing a critical information gap for emergency planning.
title: Anticipated next-day job autonomy
title: exploring dynamics, coping strategies, and implications for employee daily task behaviors and work outcomes
titleType: Subtitle
Creators: name: Ryu, Seung Whan
Publisher: name: University of Iowa
Year: 2025
Subjects: public abstract

description: This dissertation explores the dynamic nature of job autonomy and its impact on employees' daily task behaviors and work outcomes. Drawing on the theories of job autonomy and anticipatory coping, this study investigates how employees' anticipated level of job autonomy for their next working day influences their daily task behaviors and work outcomes. Using data collected from working professionals in an organization with fully implemented flexible work arrangements over ten consecutive workdays, this study explores two specific strategic daily task behaviors (purposeful task delay and working excessively) employees engage in to optimize their well-being and daily goal progress based on their expectations for future job autonomy. Contrary to the hypothesized direct relationships, anticipated next-day job autonomy did not affect daily purposeful task delay and working excessively. Moreover, purposeful task delay negatively affected daily goal progress without positive carryover effects, whereas working excessively showed a positive relationship with daily goal progress. The proposed mediation and moderation hypotheses were not supported, highlighting the need to consider alternative mechanisms. The study also uncovers the significant interaction effect between focal-day and anticipated next-day job autonomy on daily goal progress. Supplementary analyses explore the varying effects of different dimensions of anticipated job autonomy on task behaviors and work outcomes. Overall, this dissertation contributes to the understanding of job autonomy as a dynamic situational factor, employees' anticipatory coping strategies, and the nuanced relationships between job autonomy and daily work outcomes. It offers valuable insights for organizations seeking to optimize employees' task behaviors and work outcomes in the context of the daily fluctuation of job autonomy.