cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Conceptual Framework of Information Technology Strategic Issues: National and Global Strategic Documents Analysis
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: Achieving significant advances in the field of technologies, like information and communication technology, is one of the issues that has been emphasized on in strategic documents, especially the documents of the vision of the Islamic Republic of Iran in 1404. Comprehensive categorizing of the strategic issues of information technology in the national and international scale is a procedure that can provide decision-makers and policy-makers a suitable view. On the one hand, this kind of information representation causes a better definition and understanding in this area, and on the other hand, gives the policy-makers a general picture on the subject being studied.\nThe purpose of this research is to achieve conceptual framework of the strategic issues according to strategic documentation published by countries. For this, 11 4 strategic documents of information technology have been organized and analyzed by employing analyzing qualitative content method and inductive approach. The findings of this research encompasses more than 900 IT strategic issues that are in 16 main categories: e-commerce, e-organization, e-government, e-health, e-learning, other practical areas, cyberspace, information and digital content, human resources, ICT industry, information and knowledge society, infrastructure, laws, rules, procedures, information and communication technology reform, research and development and telecommunications. This article results in a comprehensive and overall look in the field of IT strategies.
The perception of the German word stress by Mandarin LI-speakers
Creators: name: Klingler, Nicola
name: Mooshammer, Christine
Publisher: name: Karl-Franzens-Universität Graz
Year: 2017

description: Grazer Linguistische Studien; Issue 88;
  Seitenzahl: 5-26; ISSN: 1015-0498;
Anaplastic thyroid cancer: How far can we go?
Creators: name: Amaral, Mariana
name: Afonso, Ricardo A.
name: Gaspar, M. Manuela
name: Reis, Catarina Pinto
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: anaplastic thyroid cancer
treatments and obstacles
challenges for innovative therapies

description: Globally, thyroid cancer accounts for 2 % of all cancer diagnoses, and can be classified as well-differentiated or undifferentiated. Currently, differentiated thyroid carcinomas have good prognoses, and can be treated with a combination of therapies, including surgical thyroidectomy, radioactive iodine therapy and hormone-based therapy. On the other hand, anaplastic thyroid carcinoma, a subtype of undifferentiated thyroid carcinoma characterized by the loss of thyroid-like phenotype and function, does not respond to either radioactive iodine or hormone therapies. In most cases, anaplastic thyroid carcinomas are diagnosed in later stages of the disease, deeming them inoperable, and showing poor response rates to systemic chemotherapy. Recently, treatment courses using multiple-target agents are being explored and clinical trials have shown very promising results, such as overall survival rates, progression-free survival and tumor shrinkage. This review is focused on thyroid carcinomas, with particular focus on anaplastic thyroid carcinoma, exploring its undifferentiated nature. Special interest will be given to the treatment approaches currently available and respective obstacles or drawbacks. Our purpose is to contribute to understand why this malignancy presents low responsiveness to current treatments, while overviewing novel therapies and clinical trials.
description: EXCLI Journal; 19:Doc800; ISSN 1611-2156
Evaluating a Conceptual Model of Credibility Evaluation of Web Information: Structural Equations Modeling Approach
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: The current research aimed to develop a localized and literature-dependent model related to credibility evaluation of web information as identified by students in top universities of Iran. In terms of its usability, the model then will be evaluated in a sample of student users in top universities of Iran. Finally, the research population for testing the model is students enrolled in top universities of Iran in curriculum year of 2016-2017. Data analysis conducted by software like LISREL 8.7 and SPSS20 which are developed for Structural Equation Modelling. Such statistic tests like confirmatory factor analysis, Pearson correlation ratio, Friedman Test, multivariate analysis of variance were used for data analysis according to each research question.  The Web Information Credibility Scale-Persian (WICS-P) was validated according to the structural and overall goodness of fit showing a high quality on measuring the variable in the context studied. There exists, however, differences among the dimensions. As the first research exploring the concept in Iran, the current research is a response to the lack of such a tool in related literature.
Book Review: Agricultural Innovation Systems in Asia: Towards Inclusive Rural Development
Creators: name: Sulaiman, Rasheed V
name: Sulaiman, Rasheed V
Publisher: name: Unknown
Year: 2020
Subjects: Community/Rural/Urban Development

description: This book points to the need for finding alternative science, technology, and innovation or STI pathways to meet the new challenges from South Asian agriculture experiences. While technological, institutional, and policy innovations continue to remain important, embracing a systems approach to agricultural development will be critical, the authors argue.
Characterizing real world safety profile of oral Janus kinase inhibitors among adult atopic dermatitis patients: evidence transporting from the rheumatoid arthritis population
Creators: name: Montez-Rath, Maria E.
name: Lubwama, Robert
name: Kapphahn, Kris
name: Ling, Albee Y.
name: LoCasale, Robert
name: Robinson, Lacey
name: Chandross, Karen J.
name: Desai, Manisha
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology

description: To address potential safety concerns of Janus Kinase Inhibitors (JAK-Is), we characterized their safety profile in the atopic dermatitis (AD) patient population. In this retrospective observational study, we used propensity score-based methods and a Poisson modeling framework to estimate the incidence of health outcomes of interest (HOI) for the AD patient. To that end, two mutually exclusive cohorts were created using a real world data resource: a rheumatoid arthritis (RA) cohort, where we directly quantify the safety risk of JAK-Is on HOIs, and an AD cohort, that comprises the target population of interest and to whom we transport the results obtained from the RA cohort. The RA cohort included all adults who filled at least one prescription for a JAK-I (tofacitinib, baricitinib, or upadacitinib) between 1 January 2017 and 31 January 2020. The AD cohort consisted of all adults diagnosed with AD during the same period. We first estimated the incidence rate of each HOI in the RA cohort, and then transported the results to the AD population. The RA and AD cohorts included 5,296 and 261,855 patients, respectively. On average, patients in the AD cohort were younger, more often male, more likely to be Asian, and had higher household income. They also had a lower prevalence of several comorbid conditions including hypertension, chronic kidney disease, obesity, and depression. Overall, the transported incidence rates of the HOIs to the AD cohort were lower than those obtained in the RA cohort by 13–50%. We applied transportability methods to characterize the risk of the HOIs in the AD population and found absolute risks higher than that of the general population. Future work is needed to validate these conclusions in comparable populations.
Book Review: Sustainability Certification Schemes in the Agricultural and Natural Science Sectors
Creators: name: Ellis, Wyn
name: Ellis, Wyn
Publisher: name: Unknown
Year: 2020
Subjects: Environmental Economics and Policy

description: Aimed at advanced students, researchers, sustainability professionals, and development practitioners, the book offers a comprehensive roadmap for assessing the utility of voluntary sustainability certification schemes. Drawing on case studies covering nine agri-food and natural resources commodities, Melissa Vogt and co-contributors assess social, cultural, and environmental outcomes for farmers in developing countries and provide a range of recommendations to further strengthen their value and sustainability impacts.
Investigation of Factors Affecting knowledge Commercialization  From the perspective of Graduated students at Shahid Rajaee Teachers’ Training University
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: Commercialization is the process of conversion of technology into successful economic products that transforms knowledge produced into marketable products and is a priority for the activities of universities and research institutes in the world. Today, the survival of universities and research centers depends on providing their knowledge in the form of knowledge products to society and the market. The main objective of this research is to determine the factors and requirements that affect the growth and success of knowledge commercialization from the viewpoint of the students of Shahid Rajaee Teacher Training University in Tehran.\nThe research method used is survey because it is one of the best methods for studying problems in real conditions and testing different variables. The statistical population consists of all graduate students of Shahid Rajaee Teacher Training University of Tehran. A randomized stratified sampling method and a data gathering tool was a semi-researcher-made questionnaire whose validity was confirmed by the opinion of the professors and its reliability was confirmed by Cronbach's alpha of 0.956. Data analysis was performed using SPSS software and Friedman statistical test.\nThe findings of the study showed that from the viewpoint of university graduate students, the most economic factors (4.14) and educational and research mechanisms have the least (3.64) effect on the growth and success of knowledge commercialization. Based on research findings, applied proposals were presented to improve the knowledge commercialization process at universities. Managers and policymakers of the university should act to facilitate the creation of companies and the commercialization of knowledge, the commercialization of knowledge and policies for distribution of income arising from the commercialization of knowledge, and in this regard, widespread networking of communication developing the role of stakeholders in knowledge-trading business process.\n
Structural analyzing of “Information Science Theories’ based on co-word network analysis of articles in Web of Science database (1983-2017)
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: The formation of intellectual currents, methods of analysis in science and methodology are the most interesting topics of science and philosophy of science. Theories of science are made up of facts that have been gathered together, arranged and discussed. This study aims to analyze the articles regarding information theories based on the concepts of co-occurrence network analysis and centrality indicators published in Web of Science during 1983-2017. This is a descriptive study, using scientometric techniques. Its statistical population contains all clinical trials related to information theories in Web of Science during 1983-2017. The scientific research on theories of information existed from 2009 to 2014. Based on the scientific map of countries, theories of information have been active in some countries including USA, Germany, United Kingdom, Spain and Canada and Brazil and China have also been active in research on this filed in these years. The top authors in theories of information field in Web of Science during 1989-2017 are Kimball, Bruner, Hersink, Lochs, and Nendersen. The mentioned authors are considered the most scientific co-authorship. Likewise, Hjørland, Hartle, White, Bushman, and Bruner have the most abundant published articles. Also, the co-authorship ratio of these authors is 0.3, which indicates a relatively high level of corporate. The analysis of information theories also showed that based on co-word analysis there are 9 clusters. Among them cluster 1 is the largest and is related to algorithms and models in theories. Other clusters are information theories-related entropy theory and its application, information theorems derived from other sciences, thermodynamics theory and physics in information science, the theory of communication and communication models, the use of interdisciplinary information theories, the effectiveness of theories, the evaluation of theories, the role of information and the role of host and importer of theories in information science and science.
Estimating the US pericarditis prevalence using National Health Encounter Surveillance Databases
Creators: name: Luis, Sushil Allen
name: LeWinter, Martin M.
name: Magestro, Matthew
name: DerSarkissian, Maral
name: Duh, Mei Sheng
name: Chang, Rose
name: Kponee-Shovein, Kalé
name: Muthukumar, Aruna
name: Hu, Xingdi
name: Lim-Watson, Michelle Z.
name: Klein, Allan L.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Computational Biology

description: To obtain a nationally representative annualized estimate of the prevalence of pericarditis (inflammation of the pericardium) in the United States (US) in order to better understand the potential burden on the health care system. Three nationally representative datasets were used to estimate the annualized period prevalence and prevalence rate of pericarditis from 2007–2016: the National Ambulatory Medical Care Survey (NAMCS), the National Hospital Ambulatory Medical Care Survey (NHAMCS), and the Nationwide Inpatient Sample (NIS). Across all data sources, ICD-9/10 codes were used to identify healthcare encounters with ≥1 primary or secondary diagnosis related to pericarditis irrespective of duration or etiology. The prevalence of pericarditis in 2020 was extrapolated by multiplying the average annualized prevalence rate from 2007–2016 by the total US population as of March 2020. Data from NAMCS/NHAMCS (2007-2016) yielded an average annualized estimate of 125,209 patients with pericarditis, resulting in a pooled average annualized prevalence estimate of 40 patients with pericarditis per 100,000 persons. Data from NIS (2007-2016) yielded an average annualized estimate of 34,441 patients with pericarditis, resulting in a pooled average annualized prevalence estimate of 11 hospitalized patients with pericarditis per 100,000 persons. Extrapolation of these results based on the March 2020 population estimates from the US Census Bureau of 329,436,928 resulted in an estimated US prevalence of pericarditis to be approximately160,000. Despite certain methodologic limitations, our analysis of data from nationally representative sources support that pericarditis is a rare disease affecting substantially fewer than 200,000 persons in the US.
The meta-analysis of smart data international researches
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: Smart data is the raw material for many activities such as automation, intelligent systems, artificial intelligence and for the fourth industrial revolution. The purpose of this study is to systematically analyze all smart data related studies published from 1980 to the end of September 2017. Also, the study of probabilistic patterns is another purpose of this research. Regarding the search model of Winer, Amike and Lee in 2008, the articles of this study were extracted using a systematic search in the Web of Science database and 220 articles were selected as the final population. They were considered to identify authors, objective, population, countries and universities, funders, years, publication terms, citation status, keywords, subject, format, language, and authorship. The main findings show that Sen Soumya has the highest number of articles (63.3%) in this field, while the United States with 33.63 percent, Princeton University with 18.3 percent, and the National Science Foundation of China with 2.72 percent have the largest share in countries, universities, and institutions. The objectives of 72.77% of articles were smart data applications and 84.54 percent of the articles have been made on nonhuman societies. Most research in this area (20.9%) was conducted in 2016. The IEEE Conference on Computer Communications Workshops has published most articles in this field (18.3%). Average citations received is 4.4. The keyword «system” (18.3%) is the most common. 39.44 percent of the published articles relate to computer science. 52/64 percent of the articles were published in the form of a conference. 18.88 percent of articles are written in English. 90.5 percent of the articles are written by single authors and 94 percent of them are written by several writers. The results of the current study indicate the variety and extent of the components studied.
Comorbidity and comedication burden among people living with HIV in the United States
Creators: name: Paudel, Misti
name: Prajapati, Girish
name: Buysman, Erin K.
name: Goswami, Swarnali
name: Mao, Jianbin
name: McNiff, Kimberly
name: Kumar, Princy
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: FOS: Biological sciences

description: To describe the burden of comorbid conditions and comedications among people living with HIV (PLWH) vs. people living without HIV (PLWoH). This was a case–control study conducted among insured patients using administrative claims data. Adult PLWH were identified by antiretroviral therapy (ART) claims or HIV/AIDS diagnosis codes from 1 January 2018 to 31 December 2018 (index date was set by the earliest claim). Continuous enrollment was required for ≥12 months pre-index (baseline) and ≥30 days post-index (follow-up). Patients were required to have ≥1 HIV diagnosis during baseline or follow-up. Those with only HIV prophylaxis were excluded. PLWoH were matched 2:1 to PLWH on demographic characteristics. Study outcomes were compared using z-tests with robust standard errors in an ordinary least squares regression or Rao–Scott tests. The study included 20,256 PLWH and 40,512 matched PLWoH, mean age 52 years. PLWH vs. PLWoH had higher mean (SD) Charlson comorbidity index scores (0.93 [1.59] vs. 0.61 [1.28]; p < .001) and a greater proportion had ≥1 comorbidity (69.1% vs. 54.5%, p < .001). The most prevalent comorbidities included hypertension (33.9% vs. 32.2%; p < .001), hyperlipidemia (29.4% vs. 24.6%; p < .001), chronic kidney disease (13.6% vs. 9.4%, p < .001), depression (13.1% vs. 7.3%, p < .001) and substance abuse (12.8% vs. 7.1%, p < .001). Mean (SD) non-ART prescription fills were higher among PLWH vs. PLWoH (11.9 [10.1] vs. 9.2 [9.4]; p < .001). Multimorbidity and polypharmacy were more prevalent among PLWH vs. matched PLWoH. Findings support the need to consider comorbidities and comedications when choosing ART and to minimize drug–drug interactions and adverse events to improve patient outcomes.
Validity Assessment in the Knowledge & Information Science Researches
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: The present study has been conducted to evaluate the amount of attention to validity assessment process of research tools, by reviewing the articles published in knowledge & information science journals in Iran over past 10 years. In this research, articles of 8 Persian scientific and research journals in the field of knowledge & information science in Iran, published between 2006 to 2015, were analyzed in a content analysis method. In total, 1763 research articles related to 211 issues of journals were analyzed and research tools and methods for determining the validity of research tools investigated. According to research findings, there was no reference to validity of research tools in 36.87% of reviewed articles. In 23.22% of articles, only validity of research tools was confirmed but the method and procedure for determining validity were not mentioned. In 4.31% of articles, researchers stated that validity of research tools was confirmed in previous studies and therefore they did not consider the validity. In 375 articles (32.38%), the method of determining validity of tools was mentioned. In terms of the methods used to measure validity of tools, results indicated that 16.66% of articles evaluated their tool validity by face validity and 20.30% by content validity method. Of other types of validity, the criterion validity was lowest, and only 2 articles (0.17%) used this method to assess validity of their tools. 5.26% of articles also used construct validity, which has highest level of validity. Also, results showed that a very small number of journals in the research population have published articles related to psychometrics of research tools. Therefore, the knowledge & information science journals are required to pay more attention to publish articles related to validity assessment of research tools for more familiarity with this process and its importance in designing tools by researchers. Also, journals in this area should be more sensitive on report of validity assessment process of research tools in the methodology section of articles in the process of reviewing articles.
Identifying structural factors for realizing knowledge governance by combination of Meta-synthesize and Delphi method
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: The purpose of this study was to identify the structural factors necessary for the realization of knowledge governance. To achieve this goal, a two-step strategy was used. In the first step, the method of meta-synthesize was carried out. By searching the databases, 319 articles were found and in the evaluation process 25 papers were finally approved. By studying these articles 25 codes and 8 concepts (including the structure for knowledge management, incentive system, communication system, formalism, centralization, management support structure, culture and work procedures) were extracted for the research question. After verifying the validity and reliability of the results, Delphi method was used in the second phase to get expert opinion. For this purpose, the output of the content required to design the Delphi questionnaire was completed and Delphi process went on to the extent that the opinions of the experts reached a consensus on the answers to the questions. Ten experts were selected based on the purposeful sampling method and Delphi method was performed to three stages. Finally, in order to answer the question of structural arrangements for the realization of knowledge governance in the organization, 14 guiding principles were presented in the form of structural and system principles. The average of Delphi experts' opinions showed that in order to realize knowledge governance, it was necessary to define the roles and responsibilities of KM, create a construct for creativity and agility, create effective communication systems for the KM, interact with creative stakeholders, create an independent knowledge management office, create a team-centered structure and encourage collaboration, define and identify the role of senior manager of knowledge in the organization's hierarchy, empower knowledge management, provide a managerial structure for knowledge management support (such as the Knowledge Management Committee or the Knowledge Management Council) create, formalize the structure of the KM, formalize systems and processes, create incentive and reward systems for knowledge governance, define and create relationships with other business units, create an organizational culture to create and share knowledge. According to a research, no article was found that could identify structural arrangements for knowledge management by using this method and Delphi; therefore, the present research is innovative in the subject and method used.
Discovery of user access pattern and loan transactions analysis of information resources using association rules technique in data mining (Case study: Libraries and Information Centers of Hamedan University of Medical Sciences)
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2019

description: Increasing massive amount of data and using them to improve the quality of management decisions are the problems of libraries and information centers. In the meantime, a powerful data mining tool can analyze data to predict and analyze user transactions and stop wasting time to use useful data from among massive data, identify valid patterns and unknown relationships, and help libraries in strategic decision-making and effective management assistance. This study using association rules technique, which is one of the data mining methods, seeks to analyze the transactions of user lending and discover their access pattern. In this cross-sectional descriptive study required data were collected from transactions of users of the libraries and information centers of Hamedan University of Medical Sciences and after preprocessing these data, the total number of 6636 user transactions was 132833 using a census method during a three-year period examined. The results of this study showed that most transactions and referrals with the score of 20.7±24.4 were related to the students and the highest delay and duration of loan respectively with the score of 884.3±1396.9 and 885.7±1765.3 related to the faculty members. Also, the rules derived from the Apriori algorithm showed by providing a users access pattern based on demographic information and determining subject dependence of information resources could be used as an appropriate pattern for analyzing and predicting user transactions.  Using association rules technique and implementing the Apriori algorithm, the best rules governing the data set were extracted. Therefore, using association rules technique can be designed as a book advisory system in libraries and information centers. Managers and policy-makers can also use these patterns and rules to align their supply and information resources with the real needs of their members, and can benefit greatly from library procurement, collection, management and services.
Management of The Organizational Context Metadata: Case Study of The Design and Codification of the Metadata Schema Registry for the Libraries of Shahidbeheshti University of Medical Sciences
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2022

description: The present study aimed to improve the management of the organizational metadata and the design of metadata registry for the library complex of ShahidBeheshti University of Medical Sciences using analytical-asystematic approach. The statistical population of the study included the metadata records from the 23 libraries (central, college, and hospital libraries) affiliated to the ShahidBeheshti University of Medical Sciences. A researcher-made questionnaire was used to collect the data on the goals and local needs of the above-mentioned libraries to generate metadata records and their management. The questionnaire was completed by the managers of the libraries and librarians in the processing and organization department using the method of observation designed by the researcher on the metadata databases for the studied libraries. Accordingly, the goals, features, and local needs of the current libraries were extracted in the field of the creation and management of metadata, as well as their policies and expectations for the future.The research findings indicate that the coherence and consistency in the creation and management of metadata is not at a desirable level for the description and organization of the content objects, as well as the consistency of metadata in accordance with the goals and local needs of the studied libraries. It seems that this inconsistency is due to some factors including the lack of clarity of all features and local needs of libraries (in general, the organizational context) and the lack of codified policies for the metadata management, as well as the lack of precision in defining their native goals and functions from the perspective of metadata management. In order to optimize the management of metadata, “the metadata registry schema of the libraries of ShahidBeheshti University of Medical Sciences” was designed in accordance with their goals and the identified local needs based on thechecklist designed in accordance with the metadata standards, including the schema objectives (the native context and data entities), formal description components (schema definition and the implementation schema), and the schema components (the metadata schema and metadata application profiles).
Ferric pyrophosphate citrate for parenteral administration of maintenance iron: structure, mechanism of action, clinical efficacy and safety
Creators: name: Fishbane, Steven
name: Ganz, Tomas
name: Pratt, Raymond D.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Anemia is a common complication in patients with hemodialysis-dependent chronic kidney disease (HDD-CKD). Anemia is principally the result of erythropoietin deficiency, inflammation, and iron deficiency. High molecular weight iron oxide nanoparticles (IONP) are routinely administered intravenously to replace iron losses and, although effective, there are lingering concerns about possible safety issues. Ferric pyrophosphate citrate (FPC, Triferic, Triferic AVNU [Triferic and Triferic AVNU are the proprietary name for ferric pyrophosphate citrate. Triferic and Triferic AVNU are registered trademarks of Rockwell medical Inc.]) is a complex iron salt that donates iron directly to plasma transferrin. FPC is devoid of any carbohydrate moiety and is administered via the dialysate or intravenously during each hemodialysis session to replace iron and maintain hemoglobin. Controlled clinical trials of up to 48 weeks in duration have demonstrated the efficacy of regular administration of dialysate FPC for maintaining hemoglobin levels and iron balance in HDD-CKD patients. Clinical data also suggest that dialysate FPC may reduce the dose requirements for and use of erythropoiesis-stimulating agents and IONPs in HDD-CKD patients. Safety data from clinical studies and post-marketing surveillance show that FPC is well tolerated and not associated with an increased risk of infection, inflammation, iron overload, or serious hypersensitivity reactions. FPC represents an effective and well-tolerated choice for iron replacement and maintenance of hemoglobin in the long-term management of HDD-CKD patients.
Floral preferences of mountain bumble bees are constrained by functional traits but flexible through elevation and season
Creators: name: Sponsler, Douglas
name: Kallnik, Katharina
name: Requier, Fabrice
name: Classen, Alice
name: Maihoff, Anne
name: Sieger, Johanna
name: Steffan-Dewenter, Ingolf
Publisher: name: Zenodo
Year: 2022
Subjects: foraging
pollinator
niche
resource selection
coexistence

description: Patterns of resource use by animals can clarify how ecological communities have assembled in the past, how they currently function, and how they are likely to respond to future perturbations. Bumble bees (Hymentoptera: Bombus spp.) and their floral hosts provide a diverse yet tractable system in which to explore resource selection in the context of plant-pollinator networks. Under conditions of resource limitation, the ability of bumble bees species to coexist should depend on dietary niche overlap. In this study, we report patterns and dynamics of floral morphotype preferences in a mountain bumble bee community based on ~13,000 observations of bumble bee floral visits recorded along a 1400 m elevation gradient. We found that bumble bees are highly selective generalists, rarely visiting floral morphotypes at the rates predicted by their relative abundances. Preferences also differed markedly across bumble bee species, and these differences were well-explained by variation in bumble bee tongue length, generating patterns of preference similarity that should be expected to predict competition under conditions of resource limitation. Within species, though, morphotype preferences varied by elevation and season, possibly representing adaptive flexibility in response to the high elevational and seasonal turnover of mountain floral communities. Patterns of resource partitioning among bumble bee communities may determine which species can coexist under the altered distributions of bumble bees and their floral hosts caused by climate and land use change.
Throwaway
Creators: name: Whitty, Jennifer
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2022
Subjects: subject: 129999 Built Environment and Design not elsewhere classified
subject: FOS: Civil engineering
subject: 160805 Social Change
subject: FOS: Sociology
subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Fashion has long been used as a vehicleof protest. Its ability to influence the social and environmentaljustice issues of our time is more evident and palpablenow, than ever before. As global tensions have amplified,clothing isa potent tool to signal our solidarity with the causeswe align with. This premiseunderpinsthe establishment of the practice-based fashion research project, Space Between. Aform ofdesign-activism and protest as described by Alastair Fuad –Luke (2009) and Von Busch (2012).Oriented towards addressing issues such as resource depletion, overconsumption and unethical production. The Space Between projectasks can wefind a sustainable balance for the fashion system,transformingnegative consumption and production patterns,by disrupting the product-service system?Its aim is to literally and figurativelyexplore the‘space between’ the linear ‘take, make and waste’ system,to createa less wasteful,inclusive,and just fashion system.
Figure S15. from Nesting success of Red-winged Blackbirds (Agelaius phoeniceus) in marshes in an anthropogenic landscape
Creators: name: Robinson, Scott K.
name: McChesney, Holly M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Map of Study Marshes HV-5
Cost of cancer management by stage of diagnosis among Medicare beneficiaries
Creators: name: Reddy, Sheila R
name: Broder, Michael S
name: Chang, Eunice
name: Paydar, Caleb
name: Chung, Karen C
name: Kansal, Anuraag R
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Estimate the annual cost of care in the 5 years following a cancer diagnosis for 17 invasive cancer types, by stage at diagnosis. We used 2012-2016 data from the Surveillance, Epidemiology, and End Results (SEER) registry-Medicare claims database to examine cost of care among Medicare beneficiaries with a confirmed cancer diagnosis based on International Classification of Diseases for Oncology, Third Edition histology codes reported in SEER. Beneficiaries contributed to the annual cost calculations (Years 1-5) using their observed time after diagnosis. Beneficiaries were continuously enrolled in fee-for-service Medicare Parts A/B and Part D during follow-up. Total, inpatient, outpatient, and pharmacy cancer-related service costs were calculated. From 2012-2016, we identified 597,778 Medicare beneficiaries with incident cancer diagnosis within 5 years (Stage I, II, III, and IV: 32.6%, 33.4%, 15.9%, and 18.0%, respectively). In Year 1, mean (standard deviation) total costs for Stage I diagnoses varied from $7,640 ($17,378) (prostate) to $94,636 ($117,636) (pancreas). Total costs increased by stage and reached $58,783 ($92,344) (prostate) to $156,982 ($175,009) (stomach) for Stage IV diagnoses in Year 1. Costs in Year 1 were significantly higher for Stage IV diagnoses than for earlier stages across all cancer types. In Years 2-5, total costs were lower than in Year 1 but continued to increase by stage. Beneficiaries diagnosed at later stages of cancer have higher costs of care (up to 7 times as much) than those diagnosed at earlier stages. Earlier cancer diagnosis may lead to more efficient treatment and decreased management cost.
Non-small cell lung cancer with EGFR exon 20 insertion mutation: a systematic literature review and meta-analysis of patient outcomes
Creators: name: Kwon, Christina Soeun
name: Lin, Huamao M.
name: Crossland, Victoria
name: Churchill, Eric N.
name: Curran, Eileen
name: Forsythe, Anna
name: Tomaras, Dimitrios
name: Ou, Sai-Hong Ignatius
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: EGFR exon 20 insertion mutation-positive non-small cell lung cancer (NSCLC) is rare, has a poor prognosis, and outcomes are not fully established. We describe and evaluate outcomes from real-world and clinical evidence in these patients. A systematic literature review (SLR) identified interventional and real-world evidence (RWE) studies reporting clinical outcomes for EGFR exon 20 insertion mutation-positive NSCLC. Meta-analyses were conducted by line of therapy to synthesize pooled survival and response outcomes across RWE. Published evidence from interventional studies was summarized individually. The SLR identified 23 RWE and 19 original interventional studies. In the meta-analysis of RWE, pooled response and survival outcomes were low for first-line EGFR-tyrosine kinase inhibitors (TKIs) and immuno-oncology (IO) agents. First-line chemotherapy resulted in a pooled ORR 25.7%, pooled PFS 5.6 months, and pooled OS 18.3 months. Pooled outcomes were further reduced in second or later lines (≥2 L): pooled ORR was 5.0%, 3.3%, and 13.9%; pooled PFS was 2.1 months, 2.3 months, and 4.4 months; and pooled OS was 14.1 months, 8.8 months, and 17.1 months (not a pooled result) for EGFR-TKIs, IO agents, and chemotherapy, respectively. Interventional studies reported outcomes for TKIs (mobocertinib, poziotinib, osimertinib, afatinib, CLN-081, DZD9008), a monoclonal antibody (amivantamab), and a heat shock protein 90 inhibitor (luminespib). While there is limited RWE for the recently approved agents mobocertinib and amivantamab, which specifically target exon 20 insertion mutations, interventional evidence supports their potential as effective treatment options. Conventional treatments used in patients with EGFR exon 20 insertion mutation-positive NSCLC have limited efficacy, though chemotherapy appeared to be associated with better response and survival outcomes than non-exon 20 targeting EGFR-TKIs and IO agents. This supports the need to identify EGFR exon 20 insertion mutations as the availability of new targeted treatments may offer additional therapeutic options to these patients.
Figure S24. from Nesting success of Red-winged Blackbirds (Agelaius phoeniceus) in marshes in an anthropogenic landscape
Creators: name: Robinson, Scott K.
name: McChesney, Holly M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Map of Study Marshes MR-7
Review of: Stein, Peter (2017). Kreolisch und Französisch. Berlin: Mouton de Gruyter
Creators: name: Moreira De Sousa, Silvio
Publisher: name: Karl-Franzens-Universität Graz
Year: 2017

description: Grazer Linguistische Studien; Issue 88;
  Seitenzahl: 105-108; ISSN: 1015-0498
Figure S6. from Nesting success of Red-winged Blackbirds (Agelaius phoeniceus) in marshes in an anthropogenic landscape
Creators: name: Robinson, Scott K.
name: McChesney, Holly M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Map of Study Marshes HF-12
Sex differences in sequelae from COVID-19 infection and in long COVID syndrome: a review
Creators: name: Sylvester, Shirley V.
name: Rusu, Rada
name: Chan, Biankha
name: Bellows, Martha
name: O’Keefe, Carly
name: Nicholson, Susan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Computational Biology

description: We conducted literature reviews to uncover differential effects of sex on sequelae from coronavirus disease 2019 (COVID-19) and on long COVID syndrome. Two authors independently searched OvidSP in Embase, Medline, Biosis, and Derwent Drug File. Publications reporting original, sex-disaggregated data for sequelae of COVID-19 (published before August 2020) and long COVID syndrome (published before June 2021) were included in the reviews. The association between COVID-19 sequelae (i.e. lasting <4 weeks after symptom onset) and sex, and between long COVID syndrome (i.e. lasting >4 weeks after symptom onset) and sex, was determined by odds ratio (OR) and 95% confidence interval (CI) (statistical significance defined by 95% CI not including 1). Of 4346 publications identified, 23 and 12 met eligibility criteria for COVID-19 sequelae and long COVID syndrome, respectively. COVID-19 sequelae in the categories of psychiatric/mood (OR = 1.80; 95% CI: 1.35–2.41), ENT (OR = 1.42; 95% CI: 1.39–1.46), musculoskeletal (OR = 1.15; 95% CI: 1.14–1.16), and respiratory (OR = 1.09; 95% CI: 1.08–1.11) were significantly more likely among females (vs. males), whereas renal sequelae (OR = 0.83; 95% CI: 0.75–0.93) were significantly more likely among males. The likelihood of having long COVID syndrome was significantly greater among females (OR = 1.22; 95% CI: 1.13–1.32), with the odds of ENT (OR = 2.28; 95% CI: 1.94–2.67), GI (OR = 1.60; 95% CI: 1.04–2.44), psychiatric/mood (OR = 1.58; 95% CI: 1.37–1.82), neurological (OR = 1.30; 95% CI: 1.03–1.63), dermatological (OR = 1.29; 95% CI: 1.05–1.58), and other (OR = 1.36; 95% CI: 1.25–1.49) disorders significantly higher among females and the odds of endocrine (OR = 0.75; 95% CI: 0.69–0.81) and renal disorders (OR = 0.74; 95% CI: 0.64–0.86) significantly higher among males. Sex-disaggregated differences for COVID-19 sequelae and long COVID syndrome were observed. Few COVID-19 studies report sex-disaggregated data, underscoring the need for further sex-based research/reporting of COVID-19 disease.
«Amunì». Tradurre i marcatori del discorso in Montalbano
Creators: name: Scivoletto, Giulio
Publisher: name: Griseldaonline
Year: 2022

description: Questo contributo tratta il rapporto tra marcatezza sociolinguistica e traduzione, esaminando il caso dei marcatori del discorso siciliani nella sottotitolazione in inglese de Il giovane Montalbano, recente produzione sul ciclo di Montalbano. L’analisi si concentra su alcuni marcatori, cruciali per la coloritura dialettale del testo (amunì, talè, nonzi, chi sacciu e ah?), proponendo un duplice metodo traduttivo, composto da traduzione funzionale e marcatura differita, che ne renda la caratterizzazione regionale. Lo studio propone dunque una riflessione sul ruolo dei marcatori del discorso nella caratterizzazione sociolinguistica di un prodotto semioticamente complesso come Montalbano.
description: Griseldaonline, Vol. 21 No. 1 (2022): Catastrofi
Figure S11. from Nesting success of Red-winged Blackbirds (Agelaius phoeniceus) in marshes in an anthropogenic landscape
Creators: name: Robinson, Scott K.
name: McChesney, Holly M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Map of Study Marshes HV-6, HV-7, and HV-9
Figure S2. from Nesting success of Red-winged Blackbirds (Agelaius phoeniceus) in marshes in an anthropogenic landscape
Creators: name: Robinson, Scott K.
name: McChesney, Holly M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Map of Study Marshes HV-3 and HV-4
Non-small cell lung cancer with EGFR exon 20 insertion mutation: a systematic literature review and pooled analysis of patient outcomes
Creators: name: Kwon, Christina Soeun
name: Lin, Huamao M
name: Crossland, Victoria
name: Churchill, Eric N.
name: Curran, Eileen
name: Forsythe, Anna
name: Tomaras, Dimitrios
name: Ou, Sai-Hong Ignatius
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: IntroductionEGFR exon 20 insertion mutation-positive non-small cell lung cancer (NSCLC) is rare, has a poor prognosis, and outcomes are not fully established. We describe and evaluate outcomes from real-world and clinical evidence in these patients. Methods: A systematic literature review (SLR) identified interventional and real-world evidence (RWE) studies reporting clinical outcomes for EGFR exon 20 insertion mutation-positive NSCLC. Meta-analyses were conducted by line of therapy to synthesize pooled survival and response outcomes across RWE. Published evidence from interventional studies was summarized individually. Results: The SLR identified 23 RWE and 19 original interventional studies. In the meta-analysis of RWE, pooled response and survival outcomes were low for first-line EGFR-tyrosine kinase inhibitors (TKIs) and immuno-oncology (IO) agents. First-line chemotherapy resulted in a pooled ORR 25.7%, pooled PFS 5.6 months, and pooled OS 18.3 months. Pooled outcomes were further reduced in second or later lines (≥2L): pooled ORR was 5.0%, 3.3%, and 13.9%; pooled PFS was 2.1 months, 2.3 months, and 4.4 months; and pooled OS was 14.1 months, 8.8 months, and 17.1 months (not a pooled result) for EGFR-TKIs, IO agents, and chemotherapy, respectively. Interventional studies reported outcomes for TKIs (mobocertinib, poziotinib, osimertinib, afatinib, CLN-081, DZD9008), a monoclonal antibody (amivantamab), and a heat shock protein 90 inhibitor (luminespib). While there is limited RWE for the recently approved agents mobocertinib and amivantamab, which specifically target exon 20 insertion mutations, interventional evidence supports their potential as effective treatment options. Conclusions: Conventional treatments used in patients with EGFR exon 20 insertion mutation-positive NSCLC have limited efficacy, though chemotherapy appeared to be associated with better response and survival outcomes than non-exon 20 targeting EGFR-TKIs and IO agents. This supports the need to identify EGFR exon 20 insertion mutations as the availability of new targeted treatments may offer additional therapeutic options to these patients.