cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study
Creators: name: Carey, L.A.
name: Li, Y.
name: Tse, C.-K.
name: Olshan, A.F.
name: Mathews, M.
name: Allott, E.H.
name: Kirk, E.L.
name: Olopade, O.I.
name: Geradts, J.
name: Hoadley, K.A.
name: Perou, C.M.
name: Troester, M.A.
name: Sun, X.
name: Thorne, L.B.
name: Robinson, W.R.
name: Reeder-Hayes, K.E.
name: Earp, H.S.
name: Hu, Z.
name: Cohen, S.M.
Publisher: name: Oxford University Press
Year: 2018

description: Background: African American breast cancer patients have lower frequency of hormone receptor-positive (HR+)/human epidermal growth factor receptor 2 (HER2)-negative disease and higher subtype-specific mortality. Racial differences in molecular subtype within clinically defined subgroups are not well understood. Methods: Using data and biospecimens from the population-based Carolina Breast Cancer Study (CBCS) Phase 3 (2008-2013), we classified 980 invasive breast cancers using RNA expression-based PAM50 subtype and recurrence (ROR) score that reflects proliferation and tumor size. Molecular subtypes (Luminal A, Luminal B, HER2-enriched, and Basal-like) and ROR scores (high vs low/medium) were compared by race (blacks vs whites) and age (≤50 years vs≥50 years) using chi-square tests and analysis of variance tests. Results: Black women of all ages had a statistically significantly lower frequency of Luminal A breast cancer (25.4% and 33.6% in blacks vs 42.8% and 52.1% in whites; younger and older, respectively). All other subtype frequencies were higher in black women (case-only odds ratio [OR] = 3.11, 95% confidence interval [CI] = 2.22 to 4.37, for Basal-like; OR=1.45, 95% CI=1.02 to 2.06, for Luminal B; OR=2.04, 95% CI=1.33 to 3.13, for HER2-enriched). Among clinically HR+/HER2- cases, Luminal A subtype was less common and ROR scores were statistically significantly higher among black women. Conclusions: Multigene assays highlight racial disparities in tumor subtype distribution that persist even in clinically defined subgroups. Differences in tumor biology (eg, HER2-enriched status) may be targetable to reduce disparities among clinically ER+/HER2- cases.
Blind Ambition
Creators: name: Skinner, Anthea
Publisher: name: University of Melbourne
Year: 2023
Subjects: classificationCode: 420318
subject: People with disability
classificationCode: 360306
subject: Musicology and ethnomusicology
classificationCode: 360304
subject: Music performance
classificationCode: 360303
subject: Music education

description: An article discussing the effects of blindness on music ability. Originally published in Link Disability Magazine, Vol 21, No 3, 2012, pp40-1.
Pathological response in a triple-negative breast cancer cohort treated with neoadjuvant carboplatin and docetaxel according to Lehmann's refined classification
Creators: name: Marquez-Rodas, I.
name: Fuentes, H.
name: Alvarez, E.
name: Monte-Millan, M.D.
name: Hoadley, K.
name: Massarrah, T.
name: Cebollero, M.
name: Moreno, F.
name: Martin, M.
name: Lopez-Tarruella, S.
name: Perou, C.M.
name: Barnadas, A.
name: García-Saenz, J.A.
name: Gomez, H.L.
name: Jerez, Y.
name: Picornell, A.
name: Ocaña, I.
name: Echavarria, I.
name: Bohn, U.
name: Gayarre, J.
name: Ballesteros, A.I.
name: Ramos-Medina, R.
Publisher: name: American Association for Cancer Research Inc.
Year: 2018

description: Purpose: Triple-negative breast cancer (TNBC) requires the identification of reliable predictors of response to neoadjuvant chemotherapy (NACT). For this purpose, we aimed to evaluate the performance of the TNBCtype-4 classifier in a cohort of patients with TNBC treated with neoadjuvant carboplatin and docetaxel (TCb). Methods: Patients with TNBC were accrued in a nonrandomized trial of neoadjuvant carboplatin AUC 6 and docetaxel 75 mg/m2 for six cycles. Response was evaluated in terms of pathologic complete response (pCR, ypT0/is ypN0) and residual cancer burden by Symmans and colleagues. Lehmann's subtyping was performed using the TNBCtype online tool from RNAseq data, and germline sequencing of a panel of seven DNA damage repair genes was conducted. Results: Ninety-four out of the 121 patients enrolled in the trial had RNAseq available. The overall pCR rate was 44.7%. Lehmann subtype distribution was 34.0% BL1, 20.2% BL2, 23.4% M, 14.9% LAR, and 7.4% were classified as ERþ. Response to NACT with TCb was significantly associated with Lehmann subtype (P ¼ 0.027), even in multivariate analysis including tumor size and nodal involvement, with BL1 patients achieving the highest pCR rate (65.6%), followed by BL2 (47.4%), M (36.4%), and LAR (21.4%). BL1 was associated with a significant younger age at diagnosis and higher ki67 values. Among our 10 germline mutation carriers, 30% were BL1, 40% were BL2, and 30% were M. Conclusions: TNBCtype-4 is associated with significantly different pCR rates for the different subtypes, with BL1 and LAR displaying the best and worse responses to NACT, respectively.
Dynamical analysis in scalar field cosmology
Creators: name: Paliathanasis, Andronikos
name: Tsamparlis, Michael
name: Basilakos, Spyros
name: Barrow, John D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We give a general method to find exact cosmological solutions for scalar-field dark energy in the presence of perfect fluids. We use the existence of invariant transformations for the Wheeler De Witt (WdW) equation. We show that the existence of a point transformation under which the WdW equation is invariant is equivalent to the existence of conservation laws for the field equations, which indicates the existence of analytical solutions. We extend previous work by providing exact solutions for the Hubble parameter and the effective dark-energy equation of state parameter for cosmologies containing a combination of perfect fluid and a scalar field whose self-interaction potential is a power of hyperbolic functions. We find solutions explicitly when the perfect fluid is radiation or cold dark matter and determine the effects of non-zero spatial curvature. Using the Planck 2015 data, we determine the evolution of the effective equation of state of the dark energy. Finally, we study the global dynamics using dimensionless variables. We find that if the current cosmological model is Liouville integrable (admits conservation laws) then there is a unique stable point which describes the de-Sitter phase of the universe.
description: 18 pages, 4 figures, minor corrections, accepted for publication by Phys. Rev. D
Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
Creators: name: Davies, S.R.
name: Ramalho, S.
name: Haricharan, S.
name: Ma, C.X.
name: Kosaka, Y.
name: Chen, X.
name: Watson, M.A.
name: Anurag, M.
name: Jou, E.
name: Kavuri, S.M.
name: Holloway, K.R.
name: Parikh, P.A.
name: Zhang, J.
name: Schmidt, C.
name: Chan, D.W.
name: Singh, P.
name: Peres, R.M.R.
name: Shao, J.
name: Tobias, E.
name: Devarakonda, V.
name: Hunt, K.K.
name: Suman, V.J.
name: Iglesia, M.
name: Ellis, M.J.
name: Lei, J.T.
name: Perou, C.M.
name: Hampton, O.
name: Crowder, R.
name: Matsunuma, R.
name: Punturi, N.
name: Cao, J.
name: Lai, W.V.
name: Rogers, A.
name: Maher, C.A.
name: Creighton, C.J.
name: Goncalves, R.
name: Thompson, E.A.
name: Bartram, A.
name: Li, S.
name: Hoog, J.
name: Phommaly, C.
name: Hoadley, K.A.
name: He, X.
Publisher: name: Elsevier B.V.
Year: 2018

description: RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found that two, both identified in advanced endocrine treatment-resistant disease, encoded stable and functional fusion proteins. In both examples, ESR1-e6>YAP1 and ESR1-e6>PCDH11X, ESR1 exons 1–6 were fused in frame to C-terminal sequences from the partner gene. Functional properties include estrogen-independent growth, constitutive expression of ER target genes, and anti-estrogen resistance. Both fusions activate a metastasis-associated transcriptional program, induce cellular motility, and promote the development of lung metastasis. ESR1-e6>YAP1- and ESR1-e6>PCDH11X-induced growth remained sensitive to a CDK4/6 inhibitor, and a patient-derived xenograft (PDX) naturally expressing the ESR1-e6>YAP1 fusion was also responsive. Transcriptionally active ESR1 fusions therefore trigger both endocrine therapy resistance and metastatic progression, explaining the association with fatal disease progression, although CDK4/6 inhibitor treatment is predicted to be effective. Lei et al. show that transcriptionally active estrogen receptor gene (ESR1) fusions identified from late-stage, treatment-refractory estrogen receptor-positive (ER+) breast cancer drive pan-endocrine therapy resistance and metastatic progression. Growth of breast tumors driven by ESR1 fusions at primary and metastatic sties can be suppressed with a CDK4/6 inhibitor.
Integrated Molecular Characterization of Testicular Germ Cell Tumors
Creators: name: Shih, J.
name: Hutter, C.M.
name: Shelley, C.S.
name: Newton, Y.
name: Tickoo, S.K.
name: Schultz, N.
name: Nathanson, K.L.
name: Mungall, A.J.
name: Laird, P.W.
name: Hegde, A.M.
name: Cortessis, V.K.
name: Liu, M.
name: Cárcano, F.M.
name: Xi, L.
name: Hollern, D.P.
name: Getz, G.
name: Thorsson, V.
name: Akbani, R.
name: Wheeler, D.A.s
name: Reuter, V.E.
name: Pluta, J.
name: Shen, H.
name: Zhang, H.
name: Cherniack, A.D.
name: Sánchez-Vega, F.
name: Meyerson, M.
name: Zhou, W.
name: Kasaian, K.
name: Vidal, D.O.
name: Stuart, J.M.
name: Noble, M.S.
name: Godoy, G.
name: Feldman, D.R.
name: The Cancer Genome Atlas Research Network
name: Heiman, D.I.
name: Kulis, T.
name: Hoadley, K.A.
name: Wang, L.
name: Felau, I.
name: ZenKlusen, J.C.
name: Brooks, D.
name: Lessel, D.
name: Armenia, J.
name: Mehra, R.
name: Jones, J.
name: Bowlby, R.
name: Cho, J.
name: Zhang, J.
name: Lichtenberg, T.M.
name: Leraas, K.M.
name: Pyle, L.C.
Publisher: name: Elsevier B.V.
Year: 2018

description: We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance—KIT, KRAS, and NRAS—exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas. Shen et al. identify molecular characteristics that classify testicular germ cell tumor types, including a separate subset of seminomas defined by KIT mutations. This provides a set of candidate biomarkers for risk stratification and potential therapeutic targeting.
D1.3 Report on statistical data SPOT
Creators: name: van Elburg, Eline
name: Pleijte, Marcel
name: Pedroli, Bas
Publisher: name: Zenodo
Year: 2022
Subjects: SPOT
deliverable
statistical data
case study area

description: Work Package 1 is mainly concerned with documenting the case study areas of the 15 SPOT partners by developing quantitative and qualitative indicators at national, regional and local levels which are appropriate for understanding the role of cultural tourism.
 This is a report on statistical data collected within the scope of the SPOT project. The purpose of this deliverable is to provide the results of the collected data, and provide an analysis and discussion comparing the results of the fifteen participating case studies. The aim is to find out more about the similarities and differences that exist among the case studies for a number of topics ranging from geography to tourism. This report was generated from the international research project Social and innovative Platform On cultural Tourism and its potential towards deepening Europeanisation (SPOT, www.SPOTprojectH2020.eu) funded by the European Commission under the H2020 Program (Grant Agreement #870644). The Consortium consists of 15 partners and is coordinated by the Mendel University in Brno.
 The project partners and Principal Investigators (PI) are:
  Mendel University in Brno (the Czech Republic), PI Prof. Milada Šťastná;
  Bar-Ilan University (Israel), PI Prof. Michael Sofer;
  Institute of Geography, Romanian Academy (Romania), PI Dr. Bianca Mitrica;
  Leibniz Institute of Ecological Urban and Regional Development (Germany), PI Dr. Peter Wirth / Dr. Ralf-Uwe Syrbe;
  Centre for Economic and Regional Studies, Hungarian Academy of Sciences (Hungary), PI Prof. Tamás Hardi;
  Wageningen Environmental Research (the Netherlands), PI Drs. Marcel Pleijte;
  Tallinn University (Estonia), PI Prof. Hannes Palang;
  University of Graz (Austria), PI Dr. Wolfgang Fischer;
  University of Aberdeen (the United Kingdom), PI Prof. Claire Wallace;
  The University of the Aegean (Greece), PI Prof. Theano S. Terkenli;
  University of Barcelona (Spain), PI Assoc. Prof. Montserrat Pareja-Eastaway;
  University of Verona (Italy), PI Assoc. Prof. Lorenzo Migliorati / Prof. Luca Mori;
  University of Wroclaw (Poland), PI Dr. Hab. Sylwia Dołzbłasz;
  University of Ljubljana (Slovenia), PI Assist. Prof. Naja Marot;
  Constantine the Philosopher University in Nitra (Slovakia), PI RNDr. PhD. Hilda Kramáreková.
Silver Linings
Creators: name: Skinner, Anthea
Publisher: name: University of Melbourne
Year: 2023
Subjects: classificationCode: 420318
subject: People with disability
classificationCode: 420502
subject: Aged care nursing
classificationCode: 420103
subject: Music therapy
classificationCode: 360306
subject: Musicology and ethnomusicology

description: Article about Silver Memories, a radio station designed specifically for aged care and dementia patients. Originally published in Link Disability Magazine, Vol 25, No 3, 2016, p51.
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
Creators: name: Rustgi, A.K.
name: Cherniack, A.D.
name: Weinstein, J.N.
name: Stuart, J.M.
name: Bowlby, R.
name: Diao, L.
name: Gevaert, O.
name: Schultz, A.
name: The Cancer Genome Atlas Research Network
name: Taylor, A.M.
name: Walter, V.
name: Lazar, A.J.
name: Chen, J.
name: Flores, E.R.
name: Hoadley, K.A.
name: Laird, P.W.
name: Sadeghi, S.
name: Yau, C.
name: Drill, E.
name: Cheng, H.
name: Anur, P.
name: Mungall, K.L.
name: Tsai, K.Y.
name: Zuna, R.
name: Gunaratne, P.
name: Donehower, L.
name: Chen, Z.
name: Gay, C.M.
name: Pickering, C.R.
name: Van Waes, C.
name: Coarfa, C.
name: Wang, C.
name: Peto, M.
name: Ojesina, A.I.
name: Hegde, A.
name: Shen, R.
name: Pedamallu, C.S.
name: Liu, Y.
name: Shih, J.
name: Wong, C.K.
name: Prunello, M.
name: Kanchi, R.S.
name: Wang, J.
name: Al-Ahmadie, H.
name: Chiu, H.-S.
name: Zhou, J.H.
name: Akbani, R.
name: Brennan, K.
name: Shen, H.
name: Ma, W.
name: Benz, C.
name: Sumazin, P.
name: Fan, H.
name: Hayes, D.N.
name: Byers, L.A.
name: Bullman, S.
name: Campbell, J.D.
name: Rader, J.S.
name: Robertson, A.G.
name: Creighton, C.J.
name: Chen, T.-W.
Publisher: name: Elsevier B.V.
Year: 2018

description: This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations, and/or aberrant methylation of genes and microRNAs, which are correlated with the expression of multi-gene programs linked to squamous cell stemness, epithelial-to-mesenchymal differentiation, growth, genomic integrity, oxidative damage, death, and inflammation. Low-CNA SCCs tended to be HPV(+) and display hypermethylation with repression of TET1 demethylase and FANCF, previously linked to predisposition to SCC, or harbor mutations affecting CASP8, RAS-MAPK pathways, chromatin modifiers, and immunoregulatory molecules. We uncovered hypomethylation of the alternative promoter that drives expression of the ΔNp63 oncogene and embedded miR944. Co-expression of immune checkpoint, T-regulatory, and Myeloid suppressor cells signatures may explain reduced efficacy of immune therapy. These findings support possibilities for molecular classification and therapeutic approaches. Campbell et al. reveal that squamous cell cancers from different tissue sites may be distinguished from other cancers and subclassified molecularly by recurrent alterations in chromosomes, DNA methylation, messenger and microRNA expression, or by mutations. These affect squamous cell pathways and programs that provide candidates for therapy.
X-Ray Detection of Transient Magnetic Moments Induced by a Spin Current in Cu
Creators: name: Kukreja, R.
name: Bonetti, S.
name: Chen, Z.
name: Backes, D.
name: Acremann, Y.
name: Katine, J.
name: Kent, A. D.
name: Durr, H. A.
name: Ohldag, H.
name: Stohr, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have used a MHz lock-in x-ray spectro-microscopy technique to directly detect changes of magnetic moments in Cu due to spin injection from an adjacent Co layer. The elemental and chemical specificity of x-rays allows us to distinguish two spin current induced effects. We detect the creation of transient magnetic moments of $3\times 10^{-5}$ $μ_\mathrm{B}$ on Cu atoms within the bulk of the 28 nm thick Cu film due to spin-accumulation. The moment value is compared to predictions by Mott's two current model. We also observe that the hybridization induced existing magnetic moments on Cu interface atoms are transiently increased by about 10% or $4\times 10^{-3}$ $μ_\mathrm{B}$. This reveals the dominance of spin-torque alignment over Joule heat induced disorder of the interfacial Cu moments during current flow.
Integrative molecular characterization of malignant pleural mesothelioma
Creators: name: Ravegnini, G.
name: TCGA Research Network
name: Husain, A.N.
name: Travis, W.D.
name: Chirieac, L.R.
name: Severson, D.T.
name: Newton, Y.
name: Sanchez-Vega, F.
name: Gibb, E.A.
name: Robertson, A.G.
name: Hmeljak, J.
name: Campbell, P.
name: Creaney, J.
name: Byers, L.A.
name: Kindler, H.
name: Gay, C.M.
name: Galateau-Sallé, F.
name: Noble, M.S.
name: Ladanyi, M.
name: Drill, E.
name: Osmanbeyoglu, H.U.
name: Kantheti, H.
name: Gibbs, D.L.
name: Takeshita, J.
name: Tsao, A.S.
name: Leraas, K.
name: Cherniack, A.D.
name: Rusch, V.W.
name: Sekido, Y.
name: Tarpey, P.
name: Akbani, R.
name: Robinson, B.W.
name: Hoadley, K.A.
name: Diao, L.
name: Zauderer, M.G.
name: Aburatani, H.
name: Dacic, S.
name: Heiman, D.
name: Iype, L.
name: Bowlby, R.
name: Kanchi, R.
name: Kwiatkowski, D.J.
name: Desmeules, P.,
name: Zenklusen, J.C.
name: Bowen, J.
name: Bueno, R.
name: Shen, R.
name: Stewart, C.
name: Fujimoto, J.
name: Pass, H.I.
name: Lichtenberg, T.
name: Shih, J.
name: Danilova, L.
name: Rintoul, R.C.
name: Felau, I.
name: Gupta, M.
name: Jungbluth, A.A.
name: Graim, K.
name: Fletcher, J.A.
name: Silveira, H.C.
name: Thorsson, V.
Publisher: name: American Association for Cancer Research Inc.
Year: 2018

description: Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkpoint gene VISTA in epithelioid MPM, strikingly higher than in other solid cancers, with implications for the immune response to MPM and for its immunotherapy. Our findings highlight new avenues for further investigation of MPM biology and novel therapeutic options. SIGNIFICANCE: Through a comprehensive integrated genomic study of 74 MPMs, we provide a deeper understanding of histology-independent determinants of aggressive behavior, define a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expresssion of the immune-checkpoint gene VISTA in epithelioid MPM.
The Integrated Genomic Landscape of Thymic Epithelial Tumors
Creators: name: Raphael, B.
name: Marino, M.
name: Huang, J.
name: Tsao, M.S.
name: Zhang, J.
name: Jo, H.
name: Leiserson, M.D.M.
name: Zhang, H.
name: Hayes, D.N.
name: Anur, P.
name: Hwang, D.
name: Matthew, T.
name: Girard, N.
name: Ha, G.
name: McLellan, M.
name: The Cancer Genome Atlas Network
name: Danilova, L.
name: Kim, J.
name: Robertson, G.
name: Tsao, A.S.
name: Felau, I.
name: Spellman, P.
name: Ströbel, P.
name: Weinstein, J.N.
name: Hegde, A.M.
name: Ryan, M.
name: Bowlby, R.
name: Hoadley, K.A.
name: Badve, S.
name: Pickering, C.R.
name: Gokmen-Polar, Y.
name: Lu, C.
name: Radovich, M.
name: Zenklusen, J.C.
name: Fujimoto, J.
name: Sethi, G.
name: Giaccone, G.
name: Korst, R.
name: Scapulatempo-Neto, C.
name: Loehrer, P.J.
name: Akbani, R.
name: Marx, A.
name: Lichtenberg, T.
name: Leraas, K.
name: Moreira, A.L.
name: Rajan, A.
name: Cherniack, A.D.
name: Su, X.
Publisher: name: Cell Press
Year: 2018

description: Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive. Using multi-platform omics analyses on 117 TETs, we define four subtypes of these tumors defined by genomic hallmarks and an association with survival and World Health Organization histological subtype. We further demonstrate a marked prevalence of a thymoma-specific mutated oncogene, GTF2I, and explore its biological effects on multi-platform analysis. We further observe enrichment of mutations in HRAS, NRAS, and TP53. Last, we identify a molecular link between thymoma and the autoimmune disease myasthenia gravis, characterized by tumoral overexpression of muscle autoantigens, and increased aneuploidy. Radovich et al. perform multi-platform analyses of thymic epithelial tumors. They identify high prevalence of GTF2I mutations and enrichment of mutations in HRAS, NRAS, and TP53 and link overexpression of muscle autoantigens and increased aneuploidy in thymoma and patients’ risk of having myasthenia gravis.
title: Synthesis and anticancer activity of NDGA and analogues
Creators: name: McDonald, Russell Walker
Publisher: name: University of Glasgow
Year: 2000
Subjects: subject: Pharmacology, organic chemistry.

description: There is an urgent need to develop novel therapeutic strategies for common solid tumours including small cell lung cancer where the five year survival rate is less than 5%. The natural product nordihydroguaiaretic acid (NDGA) (A) has been shown to block the growth of small cell lung cancer in vitro and in vivo. In order to realise the potential of NDGA as an effective anti-cancer agent we set up a collaboration with Dr. M. Seckl (Hammersmith Hospital) with the goal of producing a more potent analogue. Initially we concentrated on the synthesis of the racemate of NDGA (B) which would ascertain whether the stereochemistry of the methyl groups was important for activity. Our four step synthesis employed a pinacol coupling as the key step affording (B) in low overall yield. The preliminary test results showed (B) to be equipotent to NDGA suggesting that the stereochemistry of the methyl groups is not important for activity.To help in the determination of structural activity relationships we synthesised a series of analogues of NDGA having different bridging distances between the aromatic nuclei. The synthesis of a series of mono phenolic compounds was also undertaken following the same procedures. The diarylbutane derivative (C) was found to be 10 fold more potent than NDGA in vitro suggesting that the methyl groups of (A) hindered its activity or that improved activity was due to decreased lipophilicity. A number of amide derivatives were also synthesised allowing access to more conformationally restricted analogues. The test results showed that the secondary amide (D) was four times more potent than NDGA. However the corresponding N-Me derivative was less active. The poor aqueous solubility of NDGA has hampered its development as an effective anti-cancer agent. With this in mind, we have been working on the synthesis of a water soluble conjugate of NDGA which would release the active component over a period of time. The tetra glycyl salt (E) was synthesised. This is water soluble as expected but has slighty less activity than the parent compound. On the other hand, the ammonium salt (F) was found to be water soluble and twice as potent as NDGA and is currently undergoing in vivo testing.
THE WAYS OF WORD FORMATION IN THE ENGLISH AND UZBEK LANGUAGES.
Creators: name: Poyonova, Maftuna
Publisher: name: Zenodo
Year: 2025

description: Word formation is a fundamental aspect of linguistics, as it allows languages to expand their vocabulary and adapt to new concepts. Both English and Uzbek use a variety of methods to create new words, but the specific techniques they employ are influenced by their different linguistic structures. English, as a Germanic language with influences from Latin and French, and Uzbek, as a Turkic language with agglutinative characteristics, have some similarities and notable differences in how they form words. This article explores the primary methods of word formation in both English and Uzbek, with a focus on their similarities and distinctions.
BBMRI-ERIC Registration with hostel instructions
Creators: name: Engels, Cecilia
name: Hodselmans, Aneas
name: Van Enckevort, Esther
Publisher: name: Zenodo
Year: 2023
Subjects: BBMRI-ERIC
User manual
Registration
Biobank
Directory
AAI
Hostel

description: BBMRI Services Registration with Hostel step-by-step
Rudely Rocks
Creators: name: Skinner, Anthea
Publisher: name: University of Melbourne
Year: 2023
Subjects: classificationCode: 360304
subject: Music performance
classificationCode: 420318
subject: People with disability

description: A review of Australian band Rudely Interrupted's album Mystery Girl. Members of Rudely Interrupted have a range of disabilities. Originally published in Link Disability Magazine, Vol 22, No 1, 2013, p33.
ผู้บริหารสถานศึกษา: ภาวะผู้นำดิจิทัล
Creators: name: ภารดี อนันต์นาวี
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: ผู้บริหารสถานศึกษา
ภาวะผู้นำดิจิทัล
การบริหารจัดการ
เทคโนโลยี
คุณลักษณะ

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 1-12
Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study
Creators: name: Troester, M.A.
name: Bell, M.E.
name: Geradts, J.
name: Perou, C.M.
name: Olshan, A.F.
name: Love, M.I.
name: Tse, C.K.
name: Hoadley, K.A.
name: Williams, L.A.
name: Nichols, H.B.
Publisher: name: Springer International Publishing
Year: 2018

description: Background: Invasive lobular breast tumors display unique reproductive risk factor profiles. Lobular tumors are predominantly Luminal A subtype, and it is unclear whether reported risk factor associations are independent of molecular subtype. Methods: Polytomous logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations between risk factors and histologic subtype [ductal (n = 2,856), lobular (n = 326), and mixed ductal–lobular (n = 473)] in the Carolina Breast Cancer Study (1993–2013). Three-marker immunohistochemical clinical subtypes were defined as Luminal A (ER+ or PR+/HER2-), Luminal B (ER+ or PR+/HER2+), Triple Negative (ER−/PR−/HER2-), and HER2+ (ER−/PR−/HER2+). Results: In case–case analyses compared to ductal, lobular tumors were significantly associated with lactation duration > 12 months [OR 1.86, 95% CI (1.33–2.60)], age at first birth ≥ 26 years [OR: 1.35, 95% CI: (1.03–1.78)], and current oral contraceptive use [OR: 1.86, 95% CI: (1.08–3.20)]. Differences in risk factor associations between ductal and lobular tumors persisted after restricting to Luminal A subtype. Conclusions: Lobular tumors were associated with older age at first birth, increased lactation duration, and current oral contraceptive use. Etiologic heterogeneity by histology persisted after restricting to Luminal A subtype, suggesting both tumor histology and intrinsic subtype play integral parts in breast cancer risk.
mAkE Impact Assessment Plan
Creators: name: Schaefer, Teresa
name: Fabian, Claudia M.
name: Armstrong, Chris
Publisher: name: Zenodo
Year: 2023

description: This document describes the Impact Assessment Plan for the mAkE project. The evaluation and impact assessment of the mAkE project has two main objectives. First, we want to ensure that the project’s network structures, the capacity building support, the created infrastructures, and the created materials are developed according to the project plan and are contributing to the project objectives. Second, we aim to provide evidence of the envisioned impact, and to identify facts and stories that demonstrate the project's influence beyond the borders of the consortium, especially in terms of capacity building. The evaluation of results is organised in relation to the general objectives set up by the project, and seeks evidence of the effectiveness and efficiency of the mAkE approach at an individual level as well as at the collective and societal level for the organisations and communities involved.
การศึกษาเพื่อการเรียนรู้แนวเพลงยอดนิยมโดยใช้ทักษะของเดวีส์ สำหรับนักศึกษาชั้นปีที่ 1 สถาบันศิลปะต้าเหลียน มณฑลเหลียวหนิง
Creators: name: จ้าว เฉียน
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: ทักษะของเดวิส์
แนวเพลงยอดนิยม
ประสิทธิภาพการสอน

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 13-22
D1.4 Report on the results of surveys for tourists, residents and entrepreneurs in the case studies
Creators: name: van Elburg, Eline
name: Pleijte, Marcel
name: Pedroli, Bas
name: Donders, Josine
name: Rip, Frans
Publisher: name: Zenodo
Year: 2022
Subjects: SPOT
deliverable
survey
cultural tourism
tourists
residents
entrepreneurs
case study area

description: Work Package 1 is mainly concerned with documenting the case study areas of the 15 SPOT partners by developing quantitative and qualitative indicators at national, regional and local levels which are appropriate for understanding the role of cultural tourism.
 This is a report on three surveys conducted within the scope of the SPOT project. The purpose of this deliverable is to provide the results of the surveys for tourists, residents and entrepreneurs, and provide an analysis and discussion comparing the results of the fifteen participating case studies. The aim is to find out more about the similarities and differences that exist in tourists’, residents’ and entrepreneurs’ experiences and views on cultural tourism and about the potentials of cultural tourism. This report was generated from the international research project Social and innovative Platform On cultural Tourism and its potential towards deepening Europeanisation (SPOT, www.SPOTprojectH2020.eu) funded by the European Commission under the H2020 Program (Grant Agreement #870644). The Consortium consists of 15 partners and is coordinated by the Mendelu University in Brno.
 The project partners and Principal Investigators (PI) are:
  Mendelu University in Brno (the Czech Republic), PI Dr. Prof. Milada Šťastná;
  Bar-Ilan University (Israel), PI Prof. Michael Sofer;
  Institute of Geography, Romanian Academy (Romania), PI Dr. Bianca Mitrica;
  Leibniz Institute of Ecological Urban and Regional Development (Germany), PI Dr. Peter Wirth / Dr. Ralf-Uwe Syrbe;
  Centre for Economic and Regional Studies, Hungarian Academy of Sciences (Hungary), PI Prof. Tamás Hardi;
  Wageningen Environmental Research (the Netherlands), PI Drs. Marcel Pleijte;
  Tallinn University (Estonia), PI Prof. Hannes Palang;
  University of Graz (Austria), PI Dr. Wolfgang Fischer;
  University of Aberdeen (the United Kingdom), PI Prof. Claire Wallace;
  The University of the Aegean (Greece), PI Prof. Theano S. Terkenli;
  University of Barcelona (Spain), PI Assoc. Prof. Montserrat Pareja-Eastaway;
  University of Verona (Italy), PI Assoc. Prof. Lorenzo Migliorati / Prof. Luca Mori;
  University of Wroclaw (Poland), PI Dr. Hab. Sylwia Dołzbłasz;
  University of Ljubljana (Slovenia), PI Assist. Prof. Naja Marot;
  Constantine the Philosopher University in Nitra (Slovakia), PI RNDr. PhD. Hilda Kramáreková.
National Cancer Institute Biospecimen Evidence-Based Practices: Harmonizing Procedures for Nucleic Acid Extraction from Formalin-Fixed, Paraffin-Embedded Tissue
Creators: name:  Guan, P.
name:  Hoadley, K.A.
name:  Wheeler, D.A.
name:  Zmuda, E.
name:  Engel, K.B.
name:  Moore, H.M.
name:  Casas-Silva, E.
name:  Doddapaneni, H.V.
name:  Mungall, A.J.
name: Greytak, S.R.
Publisher: name: Mary Ann Liebert Inc.
Year: 2018

description: Variable and suboptimal biospecimen handling practices have been identified as impediments to biomarker discovery, including predictive biomarkers for oncology indicating a clear and present need for evidence-based, standardized practices. The United States and international efforts have been launched to better understand andmitigate variability during the preanalytical phase and decrease associated effects by promoting harmonization of procedures both within and across institutions. The Biorepositories and Biospecimen Research Branch (BBRB) of the United States National Cancer Institute (NCI) publishes best practice documents aimed at improving the quality of data generated from human biospecimens (https://biospecimens.cancer.gov/bestpractices/overview.asp) and sponsors research initiatives (https://biospecimens.cancer.gov/programs/default.asp) and the Biospecimen Research Database (BRD; http://biospecimens.cancer.gov/brd) to better understand thresholds and effects of individual preanalytical factors in biospecimen handling. The BRD allows users to query both a curated literature repository and standard operating procedure (SOP) library for a specific preservative, diagnosis, analyte, or preanalytical factor. The BRD incorporates information from international efforts, including those by the International Society for Biological and Environmental Repositories (ISBER) and the European Union-sponsored SPIDIA program (standardization and improvement of generic preanalytical tools and procedures for in vitro diagnostics; www.spidia.eu), among others.
title: Child and youth care through a constructive-developmental lens
Creators: name: Modlin, Heather
Publisher: name: Strathprints - University of Strathclyde
Year: 2015

description: Previously, I have written about the discrepancy that exists between child and youth care as described in the literature, and child and youth care as it occurs in practice (Modlin, 2013). Instead of being a therapeutic environment, residential care can become quite the opposite. The pervasive frustration and anxiety that can be experienced by the staff, coupled with the entrenched emotional distress of the young people, often results in power struggles and ‘counter-aggression’ (Brendtro & Ness, 1983) between the staff and the young people
Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
Creators: name: Psioda, M.
name: Smith-Roe, S.L.
name: Hoadley, K.A.
name: Vance, L.D.
name: Ibrahim, J.G.
name: Perou, C.M.
name: Simpson, D.A.
name: Kaufmann, W.K.
name: Bower, J.J.
Publisher: name: Nature Publishing Group
Year: 2017

description: Genomic instability is a hallmark of breast cancer, contributes to tumor heterogeneity, and influences chemotherapy resistance. Although Gap 2 and mitotic checkpoints are thought to prevent genomic instability, the role of these checkpoints in breast cancer is poorly understood. Here, we assess the Gap 2 and mitotic checkpoint functions of 24 breast cancer and immortalized mammary epithelial cell lines representing four of the six intrinsic molecular subtypes of breast cancer. We found that patterns of cell cycle checkpoint deregulation were associated with the intrinsic molecular subtype of breast cancer cell lines. Specifically, the luminal B and basal-like cell lines harbored two molecularly distinct Gap 2/mitosis checkpoint defects (impairment of the decatenation Gap 2 checkpoint and the spindle assembly checkpoint, respectively). All subtypes of breast cancer cell lines examined displayed aberrant DNA synthesis/Gap 2/mitosis progression and the basal-like and claudin-low cell lines exhibited increased percentages of chromatid cohesion defects. Furthermore, a decatenation Gap 2 checkpoint gene expression signature identified in the cell line panel correlated with clinical outcomes in breast cancer patients, suggesting that breast tumors may also harbor defects in decatenation Gap 2 checkpoint function. Taken together, these data imply that pharmacological targeting of signaling pathways driving these phenotypes may lead to the development of novel personalized treatment strategies for the latter two subtypes which currently lack targeted therapeutic options because of their triple negative breast cancer status.
การพัฒนาพฤติกรรมทางสังคมของเด็กปฐมวัยโดยใช้การจัดกิจกรรมกลางแจ้งแบบร่วมมือโรงเรียนบ้านนายผล (แม้นสุวรรณอุปถัมภ์)
Creators: name: ณัฐณิชา ขาววิราช
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: พฤติกรรมทางสังคม
การจัดกิจกรรมกลางแจ้งแบบร่วมมือ
เด็กปฐมวัย

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 23-31
Is the Hyporheic Zone Relevant beyond the Scientific Community?
Creators: name: Lewandowski, Jörg
name: Arnon, Shai
name: Banks, Eddie
name: Batelaan, Okke
name: Betterle, Andrea
name: Broecker, Tabea
name: Coll, Claudia
name: Drummond, Jennifer
name: Gaona, Jaime
name: Galloway, Jason
name: Gomez-Velez, Jesus
name: Grabowski, Robert
name: Herzog, Skuyler
name: Hinkelmann, Reinhard
name: Höhne, Anja
name: Hollender, Juliane
name: Horn, Marcus
name: Jaeger, Anna
name: Krause, Stefan
name: Löchner Prats, Adrian
name: Magliozzi, Chiara
name: Meinikmann, Karin
name: Mojarrad, Brian Babak Morteza
name: Mueller, Birgit
name: Peralta-Maraver, Ignacio
name: Popp, Andrea
name: Posselt, Malte
name: Putschew, Anke
name: Radke, Michael
name: Raza, Muhammad
name: Riml, Joakim
name: Robertson, Anne
name: Rutere, Cyrus
name: Schaper, Jonas
name: Schirmer, Mario
name: Schulz, Hanna
name: Shanafield, Margaret
name: Singh, Tanu
name: Ward, Adam
name: Wolke, Philipp
name: Wörman, Anders
name: Wu, Liwen
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: hyporheic zone
subject: surface water–groundwater exchange
subject: ecosystem services
subject: nutrient turnover
subject: refuge
subject: hyporheos
subject: removal of trace organic compounds
subject: emerging pollutants
subject: self-purification capacity
subject: 690 Bau von Gebäuden

description: Rivers are important ecosystems under continuous anthropogenic stresses. The hyporheic zone is a ubiquitous, reactive interface between the main channel and its surrounding sediments along the river network. We elaborate on the main physical, biological, and biogeochemical drivers and processes within the hyporheic zone that have been studied by multiple scientific disciplines for almost half a century. These previous efforts have shown that the hyporheic zone is a modulator for most metabolic stream processes and serves as a refuge and habitat for a diverse range of aquatic organisms. It also exerts a major control on river water quality by increasing the contact time with reactive environments, which in turn results in retention and transformation of nutrients, trace organic compounds, fine suspended particles, and microplastics, among others. The paper showcases the critical importance of hyporheic zones, both from a scientific and an applied perspective, and their role in ecosystem services to answer the question of the manuscript title. It identifies major research gaps in our understanding of hyporheic processes. In conclusion, we highlight the potential of hyporheic restoration to efficiently manage and reactivate ecosystem functions and services in river corridors.
Get a Real Job
Creators: name: Skinner, Anthea
Publisher: name: University of Melbourne
Year: 2023
Subjects: classificationCode: 420318
subject: People with disability
classificationCode: 360305
subject: Music technology and recording
classificationCode: 360303
subject: Music education
classificationCode: 350502
subject: Employment equity and diversity

description: An article about career opportunities for people with disability in the music industry. Originally published in Link Disability Magazine, Vol 21 Iss 4 2012 pp40-1.
ผลกระทบของการควบคุมภายในที่มีผลต่อการบริหารงบประมาณ ของกองทัพอากาศ
Creators: name: ณัฐรดา ประคองคำ
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: การควบคุมภายในการบริหาร
การเบิกจ่ายงบประมาณ
กองทัพอากาศ

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 32-41
You Can Run, You Can Hide: The Epidemiology and Statistical Mechanics of Zombies
Creators: name: Alemi, Alexander A.
name: Bierbaum, Matthew
name: Myers, Christopher R.
name: Sethna, James P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We use a popular fictional disease, zombies, in order to introduce techniques used in modern epidemiology modelling, and ideas and techniques used in the numerical study of critical phenomena. We consider variants of zombie models, from fully connected continuous time dynamics to a full scale exact stochastic dynamic simulation of a zombie outbreak on the continental United States. Along the way, we offer a closed form analytical expression for the fully connected differential equation, and demonstrate that the single person per site two dimensional square lattice version of zombies lies in the percolation universality class. We end with a quantitative study of the full scale US outbreak, including the average susceptibility of different geographical regions.
description: 13 pages, 13 figures
ความคิดเห็นต่อความสำเร็จนโยบายสาธารณะ: กรณีศึกษาโครงการคนละครึ่ง
Creators: name: ณัฐวัฒน์ สิริพรวุฒิ
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: ความสำเร็จ
นโยบายสาธารณะ
โครงการคนละครึ่ง

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 42-55
Supplementary file on the standard rheometry data, microrheology complementary data, and mucus composition data from Mucus from human bronchial epithelial cultures: rheology and adhesion across length scales
Creators: name: Jory, Myriam
name: Donnarumma, Dario
name: Blanc, Christophe
name: Bellouma, Karim
name: Fort, Aurélie
name: Vachier, Isabelle
name: Casanellas, Laura
name: Bourdin, Arnaud
name: Massiera, Gladys
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biophysics
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: The supplementary files contains detailed data mentionned in the main text on the standard rheometry results. The experiments limitations, the yield stress measurements and the non-linear (LAOS) measurements are described in details, as well as the response variability depending on the culture day. The micromanipulations performed with the optical tweezers are also detailed: The response dependance upon the probe size and materials is detailed, as well as the elastic moduli close to the interface. Fially, the mucus composition / rheology correlation can be evaluated on provided Figures, corresponding to the discussion in the main text.
ผลของการจัดกิจกรรมการแสดงบทบาทสมมติที่มีต่อพฤติกรรมความเชื่อมั่น ในตนเองของเด็กปฐมวัย โรงเรียนวัดปรมัยยิกาวาส (แสนสวัสดิ์วิทยาคาร) จังหวัดนนทบุรี
Creators: name: เพชรนรี อวยพร
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: พฤติกรรมความเชื่อมั่นในตนเอง
การจัดกิจกรรมการแสดงบทบาทสมมติ
เด็กปฐมวัย

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 56-63
Responses to provision of personalised cancer risk information: a qualitative interview study with members of the public.
Creators: name: Usher-Smith, Juliet
name: Silarova, Barbora
name: Lophatananon, Artitaya
name: Duschinsky, Robbie
name: Campbell, Jackie
name: Warcaba, Joanne
name: Muir, Kenneth
Publisher: name: Apollo - University of Cambridge Repository
Year: 2017
Subjects: Humans
Neoplasms
Risk
Attitude to Health
Health Behavior
Risk Reduction Behavior
Motivation
Intention
Life Style
Qualitative Research
Adult
Middle Aged
Female
Male
Young Adult
Health Communication
Surveys and Questionnaires
Precision Medicine
United Kingdom

description: Background It is estimated that nearly 600,000 cancer cases in the UK could have been avoided in the past five years if people had healthier lifestyles. A number of theories of behaviour change suggest that before people will change health behaviours, they must accept that a risk applies to them. This study aimed to explore the views of the public on receiving personalised cancer risk information and the potential for that information to motivate behaviour change. Methods We conducted 27 interviews with members of the public (mean age 49 ± 23 years). Each participant completed a questionnaire to allow calculation of their risk of developing the most common cancers (10 for women, 8 for men). During the interviews we presented their risk using a web-based tool developed for the study and discussions covered their views on receiving that information. Each interview was audio-recorded and then analysed using thematic analysis. Results Participants generally viewed the concept of personalised cancer risk positively. The first reaction of almost all when presented with their 10-year risk of an individual cancer without any further context was that it was low and not concerning. Views on what constituted a high risk ranged widely, from 0.5 to 60%. All felt seeing the impact of changes in lifestyle was helpful. For some this led to intentions to change behaviour, but reductions in risk were not always motivating as the risks were considered low and differences small. Conclusions Provision of personalised cancer risk was well received and may be a useful addition to other cancer prevention initiatives. Further work is needed in particular to develop ways to present cancer risk that reflect the general perception of what constitutes a risk high enough to motivate behaviour change and help patients contextualise a less well known health risk by providing a frame of reference.
แนวทางการเพิ่มประสิทธิภาพการจัดการสถานศึกษาอาชีวะเอกชน
Creators: name: ภิรมย์พร สุขชัยศรี
Publisher: name: มหาวิทยาลัยนอร์ทกรุงเทพ
Year: 2565
Subjects: ประสิทธิภาพ
สถานศึกษาอาชีวะเอกชน
ไวรัสโคโรนา 2019

description: วารสารวิชาการ มหาวิทยาลัยนอร์ทกรุงเทพ, 11, 2, 64-75