cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Polyethylenimine-based theranostic nanoplatform for glioma-targeting single-photon emission computed tomography imaging and anticancer drug delivery
Creators: name: Lingzhou Zhao
name: Jingyi Zhu
name: Jiali Gong
name: Ningning Song
name: Wu, Shan
name: Wenli Qiao
name: Jiqin Yang
name: Meilin Zhu
name: Zhao, Jinhua
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Hydrodynamic sizes of PEI.NH2-DTPA-(PEG-CTX)-mPEG, mPEI-CTX/DOX and mPEI/DOX complexes dispersed in water. Table S2. Zeta potential values of PEI.NH2-DTPA-(PEG-CTX)-mPEG, mPEI-CTX/DOX and mPEI/DOX under different pH conditions. Fig. S1. 1H NMR spectra of a PEI.NH2-mPEG, b PEI.NH2-(PEG-MAL)-mPEG, c PEI.NH2-(PEG-CTX)-mPEG, d PEI.NH2-DTPA-(PEG-MAL)-mPEG and e PEI.NH2-DTPA-(PEG-CTX)-mPEG, respectively. f Schematic illustration of the mPEI-CTX structure. Fig. S2. Photographs of the mPEI-CTX/DOX (a and b) and mPEI/DOX (d and e) dispersed in water (a and d), cell culture medium (b and e), respectively, and blank cell culture medium (c and f). Standard curve of DOX dissolved in methanol (g) and PBS with pH 5.0 (h) and 7.4 (i). Fig. S3. Hydrodynamic size distributions of a PEI.NH2-DTPA-(PEG-CTX)-mPEG, b mPEI/DOX and c mPEI-CTX/DOX dispersed in water. ITLC results of d Na99mTcO4, e mPEI-99mTc/DOX and f mPEI-CTX-99mTc/DOX on silica gel-coated fiber glass sheets using saline as the mobile phase. Fig. S4. a Radiochemical purities of mPEI-CTX-99mTc/DOX and mPEI-99mTc/DOX in PBS at room temperature and FBS at 37 ºC for 1, 2, 6 and 12 h. b CCK-8 assay of C6 cells treated with the mPEI or mPEI-CTX at different polymer concentrations for 24 and 48 h, respectively. Fig. S5. Biodistribution of the mPEI-CTX-99mTc/DOX and mPEI-99mTc/DOX at 12 h post-injection. Fig. S6. Body weight changes of the C6 tumor-bearing mice during the treatments with mPEI-CTX/DOX, mPEI/DOX, mPEI-CTX, mPEI, DOX and saline, respectively. The relative body weight was normalized according to their initial weights (Mean ± SD, n = 6). Fig. S7. H&E staining of the heart, liver, spleen, lung and kidney of the tumor-bearing mice after the 21-day treatment with mPEI-CTX/DOX, mPEI/DOX, mPEI-CTX, mPEI, DOX and saline. The scale bar in each panel indicates 200 μm.
Combating HIV stigma in low- and middle-income healthcare settings: a scoping review
Creators: name: Yang, B.
name: Yang, L.
name: Sylvia, S.Y.
name: Wei, C.
name: Wang, C.
name: Li, L.
name: Xu, R.H.
name: Hunt, S.L.
name: Smith, M.K.
name: Tang, W.
name: Xue, H.
name: Joyner, B.L., Jr.
name: Tucker, J.D.
name: Luo, D.
Publisher: name: John Wiley and Sons Inc.
Year: 2020

description: Introduction: Nearly 40 years into the HIV epidemic, the persistence of HIV stigma is a matter of grave urgency. Discrimination (i.e. enacted stigma) in healthcare settings is particularly problematic as it deprives people of critical healthcare services while also discouraging preventive care seeking by confirming fears of anticipated stigma. We review existing research on the effectiveness of stigma interventions in healthcare settings of low- and middle-income countries (LMIC), where stigma control efforts are often further complicated by heavy HIV burdens, less developed healthcare systems, and the layering of HIV stigma with discrimination towards other marginalized identities. This review describes progress in this field to date and identifies research gaps to guide future directions for research. Methods: We conducted a scoping review of HIV reduction interventions in LMIC healthcare settings using Embase, Ovid MEDLINE, PsycINFO and Scopus (through March 5, 2020). Information regarding study design, stigma measurement techniques, intervention features and study findings were extracted. We also assessed methodological rigor using the Joanna Briggs Institute checklist for systematic reviews. Results and discussion: Our search identified 8766 studies, of which 19 were included in the final analysis. All but one study reported reductions in stigma following the intervention. The studies demonstrated broad regional distribution across LMIC and many employed designs that made use of a control condition. However, these strengths masked key shortcomings including a dearth of research from the lowest income category of LMIC and a lack of interventions to address institutional or structural determinants of stigma. Lastly, despite the fact that most stigma measures were based on existing instruments, only three studies described steps taken to validate or adapt the stigma measures to local settings. Conclusions: Combating healthcare stigma in LMIC demands interventions that can simultaneously address resource constraints, high HIV burden and more severe stigma. Our findings suggest that this will require more objective, reliable and culturally adaptable stigma measures to facilitate meaningful programme evaluation and comparison across studies. All but one study concluded that their interventions were effective in reducing healthcare stigma. Though encouraging, the fact that most studies measured impact using self-reported measures suggests that social desirability may bias results upwards. Homogeneity of study results also hindered our ability to draw substantive conclusions about potential best practices to guide the design of future stigma reduction programmes.
Professionalism and Ethics: A Standardized Patient Observed Standardized Clinical Examination to Assess ACGME Pediatric Professionalism Milestones
Creators: name: Davis, A.
name: Waltz, M.
name: Cadigan, R.J.
name: Smith, M.
name: Jaswaney, R.
name: Joyner, B.
Publisher: name: NLM (Medline)
Year: 2020

description: Introduction: The ethical skills fundamental to medical practice encompass a large portion of the Accreditation Council for Graduate Medical Education (ACGME) professionalism milestones. Yet many ethical practices are difficult to reduce to milestone frameworks given the variety of traditions of moral reasoning that clinician-trainees and their colleagues might properly employ. Methods: We developed an observed standardized clinical examination (OSCE) simulation with standardized patients to assess the ethical skills captured in professionalism milestones in pediatrics. The OSCE included four vignettes based on actual cases that presented problems without a correct answer. Residents discussed ethically challenging issues with standardized patients and were evaluated on specific ethical tenets contained in the professionalism milestones. Our assessment guide for preceptors offered content for debriefing and assessment. We piloted this OSCE with seven preceptors and 17 pediatric residents in two different medical settings. Results: Residents all agreed that the four cases were realistic. All but two residents agreed that OSCEs like this one are an appropriate or objective way of assessing the ACGME professionalism milestones. All preceptors reported that they strongly agreed the assessment improved their ability to assess the professionalism milestones. Discussion: This OSCE offers a structured method to assess professionalism milestones and a forum to discuss ethical problem solving. It can also be used solely as a training exercise in ethical decision making and having difficult conversations.
Additional file 3 of Detection of Beijing strains of MDR M. tuberculosis and their association with drug resistance mutations in katG, rpoB, and embB genes
Creators: name: Gupta, Anamika
name: Sinha, Pallavi
name: Nema, Vijay
name: Gupta, Pramod K.
name: Pampi Chakraborty
name: Kulkarni, Savita
name: Nalin Rastogi
name: Anupurba, Shampa
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 3.
A national approach to pediatric sepsis surveillance
Creators: name: Agus, M.S.D.
name: Weiss, S.L.
name: Joyner, B.L.
name: Lee, G.M.
name: Gerber, J.S.
name: Kissoon, N.
name: Balamuth, F.
name: Carcillo, J.A.
name: Abanyie, F.
name: Brady, P.W.
name: Puopolo, K.M.
name: Gokhale, R.H.
name: Brilli, R.J.
name: Fiore, A.E.,
name: Klompas, M.
name: Sulton, C.D.
name: Rhee, C.
name: Epstein, L.
name: Dantes, R.
name: MacIas, C.G.
name: Hsu, H.E.
Publisher: name: American Academy of Pediatrics
Year: 2019

description: Pediatric sepsis is a major public health concern, and robust surveillance tools are needed to characterize its incidence, outcomes, and trends. The increasing use of electronic health records (EHRs) in the United States creates an opportunity to conduct reliable, pragmatic, and generalizable population-level surveillance using routinely collected clinical data rather than administrative claims or resource-intensive chart review. In 2015, the US Centers for Disease Control and Prevention recruited sepsis investigators and representatives of key professional societies to develop an approach to adult sepsis surveillance using clinical data recorded in EHRs. This led to the creation of the adult sepsis event definition, which was used to estimate the national burden of sepsis in adults and has been adapted into a tool kit to facilitate widespread implementation by hospitals. In July 2018, the Centers for Disease Control and Prevention convened a new multidisciplinary pediatric working group to tailor an EHR-based national sepsis surveillance approach to infants and children. Here, we describe the challenges specific to pediatric sepsis surveillance, including evolving clinical definitions of sepsis, accommodation of agedependent physiologic differences, identifying appropriate EHR markers of infection and organ dysfunction among infants and children, and the need to account for children with medical complexity and the growing regionalization of pediatric care. We propose a preliminary pediatric sepsis event surveillance definition and outline next steps for refining and validating these criteria so that they may be used to estimate the national burden of pediatric sepsis and support site-specific surveillance to complement ongoing initiatives to improve sepsis prevention, recognition, and treatment.
Additional file 1 of Detection of Beijing strains of MDR M. tuberculosis and their association with drug resistance mutations in katG, rpoB, and embB genes
Creators: name: Gupta, Anamika
name: Sinha, Pallavi
name: Nema, Vijay
name: Gupta, Pramod K.
name: Pampi Chakraborty
name: Kulkarni, Savita
name: Nalin Rastogi
name: Anupurba, Shampa
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1.
2018 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Creators: name: Ley, S.J.
name: Raymond, T.T.
name: Chan, M.
name: Berg, M.D.
name: Atkins, D.L.
name: Sutton, R.M.
name: Joyner, B.L., Jr
name: Duff, J.P.
name: Lasa, J.J.
name: Hazinski, M.F.
name: Topjian, A.
name: Haskell, S.E.
Publisher: name: NLM (Medline)
Year: 2018

description: This 2018 American Heart Association focused update on pediatric advanced life support guidelines for cardiopulmonary resuscitation and emergency cardiovascular care follows the 2018 evidence review performed by the Pediatric Task Force of the International Liaison Committee on Resuscitation. It aligns with the International Liaison Committee on Resuscitation's continuous evidence review process, and updates are published when the group completes a literature review based on new published evidence. This update provides the evidence review and treatment recommendation for antiarrhythmic drug therapy in pediatric shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. As was the case in the pediatric advanced life support section of the "2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care," only 1 pediatric study was identified. This study reported a statistically significant improvement in return of spontaneous circulation when lidocaine administration was compared with amiodarone for pediatric ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest. However, no difference in survival to hospital discharge was observed among patients who received amiodarone, lidocaine, or no antiarrhythmic medication. The writing group reaffirmed the 2015 pediatric advanced life support guideline recommendation that either lidocaine or amiodarone may be used to treat pediatric patients with shock-refractory ventricular fibrillation or pulseless ventricular tachycardia.
(3697) ? Chalkley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
BBMRI-ERIC Directory data structure changes : Proposal for Change
Creators: name: Hodselmans, Aneas
name: van Enckevort, Esther
Publisher: name: Zenodo
Year: 2022
Subjects: Biobanking
Directory
Datamanagment
MOLGENIS
BBMRI
BBMRI-ERIC
Manual
Data structure
Proposal

description: In this document we propose a couple of changes to the data model of the BBMRI-ERIC Directory. Most of these changes are structural changes to make it easier for the National Nodes to fill in the data in the Directory and limit duplication of data. 
Does family presence in the trauma bay help or hinder care?
Creators: name: Joyner, B.L., Jr
Publisher: name: American Medical Association
Year: 2018

description: Family presence during a pediatric resuscitation remains somewhat controversial. Opponents express concern that family presence would be detrimental to team performance and that exposure to such a traumatic event could put family members at risk of posttraumatic stress. Proponents argue that family presence affords families a sense of closure by easing their anxieties and assuring them that everything was done for their loved ones in addition to improving clinicians' professional behavior by humanizing the patient. This article will review the literature on the potential benefits and pitfalls of family presence during a pediatric resuscitation.
Tadarida latouchei Thomas 1920
Creators: name: Wilson, Don E.
name: Mittermeier, Russell A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Molossidae
Tadarida
Tadarida latouchei

description: 113. La Touche’s Free-tailed Bat Tadarida latouchei French: Tadaride de La Touche / German: La-Touche-Bulldogfledermaus / Spanish: Murciélago rabudo de La Touche Taxonomy. Tadarida latouchei Thomas, 1920, “Chin-wang-tao, N.E. Chihli, China.” ladarida latouchei was previously considered a subspecies of 1. teniotis; currently recognized as a distinct species, but further revision is needed. Monotypic. Distribution. Disjunct locations in NE China (Liaoning, Inner Mongolia [= Nei Mongol], Hebei, Beijing, and Shandong), N & C Laos, and NE Thailand (Loei Province). There are three vagrant records in Japan, on Amami-Oshima, Kuchinoerabujima, and Yoronjima Is. Descriptive notes. Head—-body 67-72 mm, tail 41-49 mm, ear 22-27 mm, forearm 53-57 mm. No specific data are available for hindfoot length or body weight. Hairs are short, soft and velvety; dorsal fur is dark brown or grayish brown; ventralside is paler. Upperlip is wrinkled. Ears are large andjoined by a flap of narrow skin over forehead. Wing membrane is attached to basal one-third oftibia. Habitat. In Thailand, La Touche’s Free-tailed Bat has been recorded in dry evergreen hill forest at 1500 m. Food and Feeding. No information. Breeding. No information. Activity patterns. La Touche’s Free-tailed Bat is known to roost in caves. Movements, Home range and Social organization. [La Touche’s Free-tailed Bat was recorded forming a large colony in Laos. Status and Conservation. Classified as Data Deficient on The IUCN Red List. Population size 1s decreasing and La Touche’s Free-tailed Bat is thought to be at risk due to hunting for food and roost disturbance. Bibliography. Abe et al. (2005), Corbet & Hill (1992), Francis (2008a), Francis & Maeda (2008), Funakoshi & Kunisaki (2000), Kock (1999), Simmons (2005), Smith & Xie Yan (2008), Wang Yingxiang (2003).
description: Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Molossidae, pp. 598-672 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on page 667, DOI: 10.5281/zenodo.6418279
(3698) Mona Alison Wynne Sayer
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Electromagnetic Waves in a Uniform Gravitational Field and Planck's Postulate
Creators: name: Acedo, L.
name: Tung, M. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The gravitational redshift forms the central part of the majority of the classical tests for the general theory of relativity. It could be successfully checked even in laboratory experiments on the earth's surface. The standard derivation of this effect is based on the distortion of the local structure of spacetime induced by large masses. The resulting gravitational time-dilation near these masses gives rise to a frequency change of any periodic process, including electromagnetic oscillations as the wave propagates across the gravitational field. This phenomenon can be tackled with classical electrodynamics assuming a curved spacetime background and Maxwell's equations in a generally covariant form. In the present paper, we show that in a classical field-theoretical context the gravitational redshift can be interpreted as the propagation of electromagnetic waves in a medium with corresponding conductivity $σ=g/(μ_0 c^3)$, where $g$ is the gravitational acceleration and $μ_0$ is the vacuum magnetic permeability. Moreover, the energy density of the wave remains proportional to its frequency in agreement with Planck's postulate.
description: 16 pages, 2 figures
2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Creators: name: Duff, J.P.
name: Atkins, D.L.
name: Schexnayder, S.M.
name: Berger, S.
name: Joyner, B.L., Jr
name: Niles, D.E.
name: Samson, R.A.
name: Bigham, B.L.
name: Meaney, P.A.
name: Hunt, E.A.
name: de Caen, A.R.
Publisher: name: NLM (Medline)
Year: 2018

description: This focused update to the American Heart Association guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care follows the Pediatric Task Force of the International Liaison Committee on Resuscitation evidence review. It aligns with the International Liaison Committee on Resuscitation's continuous evidence review process, and updates are published when the International Liaison Committee on Resuscitation completes a literature review based on new science. This update provides the evidence review and treatment recommendation for chest compression-only CPR versus CPR using chest compressions with rescue breaths for children <18 years of age. Four large database studies were available for review, including 2 published after the "2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care." Two demonstrated worse 30-day outcomes with chest compression-only CPR for children 1 through 18 years of age, whereas 2 studies documented no difference between chest compression-only CPR and CPR using chest compressions with rescue breaths. When the results were analyzed for infants <1 year of age, CPR using chest compressions with rescue breaths was better than no CPR but was no different from chest compression-only CPR in 1 study, whereas another study observed no differences among chest compression-only CPR, CPR using chest compressions with rescue breaths, and no CPR. CPR using chest compressions with rescue breaths should be provided for infants and children in cardiac arrest. If bystanders are unwilling or unable to deliver rescue breaths, we recommend that rescuers provide chest compressions for infants and children.
Conductance and absolutely continuous spectrum of 1D samples
Creators: name: Bruneau, Laurent
name: Jakšić, Vojkan
name: Last, Yoram
name: Pillet, Claude-Alain
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We characterize the absolutely continuous spectrum of the one-dimensional Schrödinger operators $h=-Δ+v$ acting on $\ell^2(\mathbb{Z}_+)$ in terms of the limiting behavior of the Landauer-Büttiker and Thouless conductances of the associated finite samples. The finite sample is defined by restricting $h$ to a finite interval $[1,L]\cap\mathbb{Z}_+$ and the conductance refers to the charge current across the sample in the open quantum system obtained by attaching independent electronic reservoirs to the sample ends. Our main result is that the conductances associated to an energy interval $I$ are non-vanishing in the limit $L\to\infty$ iff ${\rm sp}_{\rm ac}(h)\cap I=\emptyset$. We also discuss the relationship between this result and the Schrödinger Conjecture.
A 15-Year-Old Boy with Progressive Weakness after a Spider Bite
Creators: name: Lercher, D.M.
name: Christian, R.B.
name: McNeal-Trice, K.
name: Joyner, B.L.
name: Ciccone, E.J.
Publisher: name: SAGE Publications Inc.
Year: 2017

description: A 15-year-old boy presented to the emergency department at a referring facility with right lower extremity weakness and numbness. He reported being bitten in the right inguinal region by a spider similar in appearance to a brown recluse several hours prior to symptom onset. He first developed redness and pain at the site of the bite followed by stiffening, numbness, tingling, and weakness of the entire right lower extremity, intermittent right digital paresthesias, diffuse myalgias, headache, and abdominal pain. His initial examination was significant for an area of ecchymosis and erythema on his anterior right hip consistent with the location of the reported bite, inability to move his right lower extremity, slightly decreased right hand strength, decreased sensation to light touch over entire right lower extremity, and right patellar areflexia. The patient reported difficulty urinating, and a postvoid bladder ultrasound revealed a residual of approximately 1 L of urine. Initial evaluation, including a complete blood count with differential, basic metabolic panel, urinalysis, and magnetic resonance imaging (MRI) of the lumbar spine was normal.
Using high-fidelity simulation for critical event training
Creators: name: Blasius, K.
name: Willie, C.
name: Chen, F.
name: Joyner, B.L.
Publisher: name: Blackwell Publishing Ltd
Year: 2016

description: What problems were addressed? Paediatric emergencies are infrequent, but can rapidly become disastrous as the limited reserve of the paediatric patient may afford only seconds for the making of appropriate clinical decisions. Operating room (OR) staff are essential to ensuring the appropriate initial steps to stabilise the patient are taken.
A Search for Dyson Spheres Using Space-Based Photometric Surveys
Creators: name: Suazo, Matias
Publisher: name: Zenodo
Year: 2022

description: Abstract: The search for intelligent life beyond Earth represents one of the most captivating quests that humanity has ever undertaken. In addition to the signal-based SETI strategy, there are strategies to search for indirect signs of extraterrestrial technology. A reasonably generic expectation is that technologically advanced civilizations would ultimately strive to overcome the resource limitations of their home planet. One way of doing this would be to tap into the radiation energy of one’s host star by constructing a so-called Dyson sphere – a structure or suite of structures that absorb some fraction of the photons that the star would otherwise radiate into interstellar space. As in any thermodynamic process, the conversion of stellar energy would involve the emission of waste heat emitted as infrared radiation that can serve as a signature of its existence. On the other hand, these “partial” Dyson spheres would block some of their host stellar light, leading to a drop in their optical fluxes. Nowadays, we count on missions that have mapped the sky in the optical and infrared, specifically Gaia, 2MASS, and WISE. We use this data to create a family of Dyson sphere models, i.e., models with different temperatures and covering factors. Then, we compare these models with stars with the best photometry in our vicinity of 300 pc to seek resemblances to create a candidates list that will undergo follow-up observations. Additionally, we compare the spectral energy distribution of our models with that of potential interlopers, such as Pre-main sequence stars.
Additional file 1 of Incidence of idiopathic cardiomyopathy in patients with type 2 diabetes in Taiwan: age, sex, and urbanization status-stratified analysis
Creators: name: Hua-Fen Chen
name: Chang, Ya-Hui
name: Hsien-Jung Lo
name: Isfandiari, Muhammad Atoillah
name: Martini, Santi
name: Hou, Wen-Hsuan
name: Li, Chung-Yi
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 1: Table S1. Relative hazards of idiopathic cardiomyopathy (ICD9 = 425.4; ICD10 = I42.0) in relation to diabetic and control groups accompanied by selected clinical comorbidities.
A noninvasive hemoglobin monitor in the pediatric intensive care unit
Creators: name: Khoury, A.L.
name: Cairns, B.A.
name: Charles, A.G.
name: Phillips, M.R.
name: Bortsov, A.V.
name: Joyner, B.L., Jr.
name: McLean, S.E.
name: Short, K.A.
name: Marzinsky, A.
Publisher: name: Academic Press Inc.
Year: 2015

description: Background Critically ill pediatric patients frequently require hemoglobin monitoring. Accurate noninvasive Hb (SpHb) would allow practitioners to decrease anemia from repeated blood draws, traumatic blood draws, and a decreased number of laboratory Hb (LabHb) medical tests. The Food and Drug Administration has approved the Masimo Pronto SpHb and associated Rainbow probes; however, its use in the pediatric intensive care unit (PICU) is controversial. In this study, we define the degree of agreement between LabHb and SpHb using the Masimo Pronto SpHb Monitor and identify clinical and demographic conditions associated with decreased accuracy. Materials and methods We performed a prospective, observational study in a large PICU at an academic medical center. Fifty-three pediatric patients (30-d and 18-y-old), weighing >3 kg, admitted to the PICU from January-April 2013 were examined. SpHb levels measured at the time of LabHb blood draw were compared and analyzed. Results Only 83 SpHb readings were obtained in 118 attempts (70.3%) and 35 readings provided a result of "unable to obtain." The mean LabHb and SpHb were 11.1 g/dL and 11.2 g/dL, respectively. Bland-Altman analysis showed a mean difference of 0.07 g/dL with a standard deviation of ±2.59 g/dL. Pearson correlation is 0.55, with a 95% confidence interval between 0.38 and 0.68. Logistic regression showed that extreme LabHb values, increasing skin pigmentation, and increasing body mass index were predictors of poor agreement between SpHb and LabHb (P < 0.05). Separately, increasing body mass index, hypoxia, and hypothermia were predictors for undetectable readings (P < 0.05). Conclusions The Masimo Pronto SpHb Monitor provides adequate agreement for the trending of hemoglobin levels in critically ill pediatric patients. However, the degree of agreement is insufficient to be used as the sole indicator for transfusion decisions and should be used in context of other clinical parameters to determine the need for LabHb in critically ill pediatric patients.
Bronchoscopy-Derived Correlates of Lung Injury following Inhalational Injuries: A Prospective Observational Study
Creators: name: Maile, R.
name: Joyner Jr., B.L.
name: Peden, D.B.
name: Jaspers, I.
name: Jones, S.W.
name: Short, K.A.
name: Zhou, H.
name: Zhang, H.
name: Kesic, M.
name: Herbst, M.
name: Noah, T.L.
name: Ortiz-Pujols, S.M.
name: Cairns, B.A.
name: Meyer, A.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Background: Acute lung injury (ALI) is a major factor determining morbidity following burns and inhalational injury. In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studies have been done in humans. Methods: We carried out a prospective observational study of patients admitted to the NC Jaycees Burn Center who were intubated and on mechanical ventilation for burns and suspected inhalational injury. Subjects were enrolled over an 8-month period and followed till discharge or death. Serial bronchial washings from clinically-indicated bronchoscopies were collected and analyzed for markers of cell injury and inflammation. These markers were compared with clinical markers of ALI. Results: Forty-three consecutive patients were studied, with a spectrum of burn and inhalation injury severity. Visible soot at initial bronchoscopy and gram negative bacteria in the lower respiratory tract were associated with ALI in univariate analyses. Subsequent multivariate analysis also controlled for % body surface area burns, infection, and inhalation severity. Elevated IL-10 and reduced IL-12p70 in bronchial washings were statistically significantly associated with ALI. Conclusions: Independently of several factors including initial inhalational injury severity, infection, and extent of surface burns, high early levels of IL-10 and low levels of IL-12p70 in the central airways are associated with ALI in patients intubated after acute burn/inhalation injury. Lower airway secretions can be collected serially in critically ill burn/inhalation injury patients and may yield important clues to specific pathophysiologic pathways.
(3691) Christopher Rivington
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Monitoring the temperature and reverberation delay of the circumnuclear hot dust in NGC 4151
Creators: name: Schnuelle, K.
name: Pott, J. -U.
name: Rix, H. -W.
name: Peterson, B. M.
name: De Rosa, G.
name: Shappee, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A hot, dusty torus located around the outer edge of the broad-line region of AGNs is a fundamental ingredient in unified AGN models. While the existence of circumnuclear dust around AGNs at pc-scale radii is now widely accepted, questions about the origin, evolution and long-term stability of these dust tori remain unsettled.\\ We used reverberation mapping of the hot circumnuclear dust in the Seyfert 1 galaxy NGC 4151, to monitor its temperature and reverberation lag as a function of the varying accretion disk brightness. We carried out multiband, multiepoch photometric observations of the nucleus of NGC 4151 in the z,Y,J,H, and K bands for 29 epochs from 2010 January to 2014 June, supported by new near-infrared and optical spectroscopic observations, and archived WISE data.\\ We see no signatures of dust destruction due to sublimation in our data, since they show no increase in the hot dust reverberation delay directly correlated with substantial accretion disk flux increases in the observed period. Instead, we find that the hot dust in NGC 4151 appears to merely heat up, and the hot dust temperature closely tracks the accretion disk luminosity variations. We find indications of a decreased reverberation delay within the observed period from t = 42.5 +/- 4.0 days in 2010 to t = 29.6 +/- 1.7 days in 2013-2014. Such a varying reverberation radius on longer timescales would explain the intrinsic scatter observed in the radius-luminosity relation of dust around AGNs.\\ Our observations rule out that a second, larger dust component within a 100-light-day radius from the source contributes significantly to the observed near-infrared flux in this galaxy.
description: Accepted for publication in Astronomy & Astrophysics. 18 pages, 15 figures, 7 tables
Additional file 1 of Extra-pair paternity and antiparasitic defence
Creators: name: Møller, Anders Pape
name: Søraker, Jørgen Skavdal
name: Soler, Juan José
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Sample size of avian nests used to estimate prevalence of extra-pair paternity of the 60 bird species used in the study.
Technosignatures in the Solar System
Creators: name: Lazio, Joseph
Publisher: name: Zenodo
Year: 2022

description: Abstract: NASA has five robotic space probes on escape trajectories from the solar system (Pioneer 11, Pioneer 12, Voyager 1, Voyager 2, and New Horizons), and the Interstellar Probe is a concept likely to be submitted for consideration in the forthcoming Solar & Space Physics Decadal Survey. While none of these robotic probes will be operational on the time scale that it would take to reach another star, it is natural to ask whether another civilization might also be sending out interstellar probes. Serious consideration of such interstellar probes dates at least to R. Bracewell in the early 1960s, and the discovery of 1I/2017 ‘Oumuamua has rekindled some of that interest.
 I consider what limits exist on signatures of extraterrestrial technology might be present in the Solar System, considering both objects on various orbits (“probes”) and surface artifacts, using data available from planetary exploration and astronomical sky surveys. Perhaps not surprisingly, the completeness to which the Solar System has been searched varies as a function of distance from the Sun. However, with notable exceptions, only extremely crude limits can be placed on the existence of interstellar probes. I also highlight areas that might be profitable for improving these limits considerably.
The nonextensive parameter for the rotating astrophysical systems with power-law distributions
Creators: name: Yu, Haining
name: Du, Jiulin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We study the nonextensive parameter for the rotating astrophysical systems with power-law distributions, including both the rotating self-gravitating system and the rotating space plasma. We extend the equation of nonextensive parameter to complex system with arbitrary force field, and derive a general equation of the q-parameter, most generally including both the rotating self-gravitating systems and the rotating space plasmas. At the same time, we reproduce the kappa-distribution in space plasmas and obtain equations of the kappa-parameter. We show that the q-parameter is related not only to the temperature gradient, the gravitational force and the electromagnetic force, but also to the inertial centrifugal force and Coriolis force. Thus the rotation introduces significant effect on nonextensivity in the systems. Several examples are given to illustrate the nonextensive effect introduced by the rotation.
description: 11 pages, 56 references
An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
Creators: name: Cohen, T.J.
name: Peterson, C.
name: Tripathy, A.
name: Lobrovich, R.
name: Ajit, A.
name: Trzeciakiewicz, H.
name: Itano, M.S.
name: Trojanowski, J.Q.
name: Moy, S.S.
name: Chen, Y.
name: Lee, V.M.Y.
name: Tabassum, Z.
name: Irwin, D.J.
name: Riddick, N.V.
name: Tseng, J.-H.
name: Ajit, D.
Publisher: name: Nature Research
Year: 2020

description: Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates tau acetylation, but its role in tauopathy progression remains unclear. Here, we identified an HDAC6-chaperone complex that targets aberrantly modified tau. HDAC6 not only deacetylates tau but also suppresses tau hyperphosphorylation within the microtubule-binding region. In neurons and human AD brain, HDAC6 becomes co-aggregated within focal tau swellings and human AD neuritic plaques. Using mass spectrometry, we identify a novel HDAC6-regulated tau acetylation site as a disease specific marker for 3R/4R and 3R tauopathies, supporting uniquely modified tau species in different neurodegenerative disorders. Tau transgenic mice lacking HDAC6 show reduced survival characterized by accelerated tau pathology and cognitive decline. We propose that a HDAC6-dependent surveillance mechanism suppresses toxic tau accumulation, which may protect against the progression of AD and related tauopathies.
A General Mechanism Design Methodology for Social Utility Maximization with Linear Constraints
Creators: name: Sinha, Abhinav
name: Anastasopoulos, Achilleas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: Social utility maximization refers to the process of allocating resources in such a way that the sum of agents' utilities is maximized under the system constraints. Such allocation arises in several problems in the general area of communications, including unicast (and multicast multi-rate) service on the Internet, as well as in applications with (local) public goods, such as power allocation in wireless networks, spectrum allocation, etc. Mechanisms that implement such allocations in Nash equilibrium have also been studied but either they do not possess full implementation property, or are given in a case-by-case fashion, thus obscuring fundamental understanding of these problems. In this paper we propose a unified methodology for creating mechanisms that fully implement, in Nash equilibria, social utility maximizing functions arising in various contexts where the constraints are convex. The construction of the mechanism is done in a systematic way by considering the dual optimization problem. In addition to the required properties of efficiency and individual rationality that such mechanisms ought to satisfy, three additional design goals are the focus of this paper: a) the size of the message space scaling linearly with the number of agents (even if agents' types are entire valuation functions), b) allocation being feasible on and off equilibrium, and c) strong budget balance at equilibrium and also off equilibrium whenever demand is feasible.
(3693) James Black
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Influence of Murine Genetic Background in Adeno-Associated Virus Transduction of the Mouse Brain
Creators: name: He, T.
name: Earley, L.F.
name: Hall, N.E.
name: Samulski, R.J.
name: Riddick, N.
name: Li, C.
name: Itano, M.S.
Publisher: name: Mary Ann Liebert Inc.
Year: 2019

description: Adeno-associated virus (AAV) vectors have become an important tool for delivering therapeutic genes for a wide range of neurological diseases. AAV serotypes possess differential cellular tropism in the central nervous system. Although several AAV serotypes or mutants have been reported to transduce the brain efficiently, conflicting data occur across studies with the use of various rodent strains from different genetic backgrounds. Herein, we performed a systematic comparison of the brain transduction properties among five AAV serotypes (AAV2, 5, 7, 8, and 9) in two common rodent strains (C57BL/6J and FVB/N), following local intrastriatal injection of AAV vectors encoding enhanced green fluorescent protein (EGFP) driven by the CBh promoter. Important differences were found regarding overall cellular tropism and transduction efficiency, including contralateral transduction among the AAV serotypes and between the mouse strains. We have further found loss of NeuN-immunoreactivity and microglial activation from AAV transduction in the different mouse strains. The important strain-specific differences from our study suggest that the genetic background of the mouse may affect AAV serotype transduction properties in the brain. These data can provide valuable information about how to choose an effective AAV vector for clinical application and interpret the data obtained from preclinical studies and clinical trials.
Temporal and spatial organization of ESCRT protein recruitment during HIV-1 budding
Creators: name: Bleck, M.
name: Simon, S.M.
name: Johnson, D.S.
name: North, A.J.
name: Itano, M.S.
name: Thomas, V.K.
name: Bieniasz, P.D.
Publisher: name: National Academy of Sciences
Year: 2014

description: HIV-1 virions assemble at the plasma membrane of mammalian cells and recruit the endosomal sorting complex required for transport (ESCRT) machinery to enable particle release. However, little is known about the temporal and spatial organization of ESCRT protein recruitment. Using multiple-color live-cell total internal reflection fluorescence microscopy, we observed that the ESCRT-I protein Tsg101 is recruited together with Gag to the sites of HIV-1 assembly, whereas later-acting ESCRT proteins (Chmp4b and Vps4A) are recruited sequentially, once Gag assembly is completed. Chmp4b, a protein that is required to mediate particle scission, is recruited to HIV-1 assembly sites ∼10 s before the ATPase Vps4A. Using two-color superresolution imaging, we observed that the ESCRT machinery (Tsg101, Alix, and Chmp4b/c proteins) is positioned at the periphery of the nascent virions, with the Tsg101 assemblages positioned closer to the Gag assemblages than Alix, Chmp4b, or Chmp4c. These results are consistent with the notion that the ESCRT machinery is recruited transiently to the neck of the assembling particle and is thus present at the appropriate time and place to mediate fission between the nascent virus and the plasma membrane.
Technological Innovations in Training: A Tool for Deriving Strategic Advantage by Organizations
Creators: name: Maxwell, Amita
name: Boohene, David
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 350503
subject: Human resources management
classificationCode: 350307
subject: Technology management
classificationCode: 390305
subject: Professional education and training

description: In order to stay competitive and be positioned competitively, organizations need to align business goals and objectives with its strategy. Strategic training is an area in human resource management where training needs need to be aligned with organizational vision, mission, business definition, and objectives in order to use training as an internal resource to form as its core competence and derive strategic advantage. Technology based training has altered the entire landscape of training. Organizations are globally using technology in order to derive competitive advantage worldwide. This has led to evolution of online training practices which should be viewed as strategic and integrated of the broader training and development strategy. Technology should be considered as part of strategic framework. Technology is constantly improving and way of doing things has tremendously changed. The impact of technology can be seen in all aspects of organizational functioning. Many companies are now starting to develop learning portals or looking at implementing enterprise learning management systems. These systems support all types of learning and integrate online learning delivery as well as classroom delivery and other forms. The present paper aims at exploring and understanding the meaning and nature of online training, issues to be dealt with while adopting online training methods and prospects of online training in deriving strategic advantage by organizations worldwide.