title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐ°ÐºÑÐ¾ÑÐ° ÑÐ±Ð¾ÑÐºÐ¸ Ð¸ ÑÐµÐ¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ñ ÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð° CHD1 Ð½Ð° ÑÑÑÑÐºÑÑÑÑ Ð³ÐµÑÐµÑÐ¾Ñ ÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Study of the influence of the chromatin assembly and remodeling factor CHD1 on the structure of heterochromatin
Creators: name: Ð¨Ð°Ð»Ð°ÐµÐ², ÐÐ½Ð´ÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: CHD1
Ð´Ð¾Ð·Ð¾Ð²Ð°Ñ ÐºÐ¾Ð¼Ð¿ÐµÐ½ÑÐ°ÑÐ¸Ñ
Ð³ÐµÑÐµÑÐ¾Ñ ÑÐ¾Ð¼Ð°ÑÐ¸Ð½
Drosophila melanogaster
MSL-ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ
dosage compensation
heterochromatin
MSL complex

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾Ð¹ Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ð¸ Ð±ÐµÐ»ÐºÐ° CHD1 Ð¼ÐµÐ¶Ð´Ñ ÑÐµÐ³ÑÐ»ÑÑÐ¸ÐµÐ¹ ÑÑÑÑÐºÑÑÑÑ Ð¥-ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ñ Ð¸ ÑÐµÐ³ÑÐ»ÑÑÐ¸ÐµÐ¹ ÑÑÑÑÐºÑÑÑÑ Ð¿ÑÐ¸ÑÐµÐ½ÑÑÐ¾Ð¼ÐµÑÐ½Ð¾Ð³Ð¾ Ð³ÐµÑÐµÑÐ¾ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð° Ð¸ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð° ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ñ 4 Ð² Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð½ÑÑ ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ð°Ñ ÑÐ»ÑÐ½Ð½ÑÑ Ð¶ÐµÐ»ÐµÐ· D. melanogaster. CHD1 â Ð²ÑÑÐ¾ÐºÐ¾ ÐºÐ¾Ð½ÑÐµÑÐ²Ð°ÑÐ¸Ð²Ð½ÑÐ¹ ÐÐ¢Ð¤-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼ÑÐ¹ ÑÐ°ÐºÑÐ¾Ñ ÑÐ±Ð¾ÑÐºÐ¸ Ð¸ ÑÐµÐ¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð°, Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÑÑÐ¸Ð¹ ÑÑÐ´ Ð²Ð°Ð¶Ð½ÑÑ ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð² ÑÑÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ðµ. ÐÑÐ»Ð¾ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸ ÑÐ²ÐµÑÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ ÐºÐ°ÑÐ°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¸ Ð½ÐµÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ CHD1 Ð¸ CHD1 Ð´Ð¸ÐºÐ¾Ð³Ð¾ ÑÐ¸Ð¿Ð° Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð´Ð¸Ñ Ð½ÐµÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¿ÑÐ¸Ð²Ð»ÐµÑÐµÐ½Ð¸Ðµ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð±ÐµÐ»ÐºÐ° Ð² ÑÑÐ¾Ð¼Ð¾ÑÐµÐ½ÑÑ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐµÐ¹ Ð´ÐµÐºÐ¾Ð½Ð´ÐµÐ½ÑÐ°ÑÐ¸ÐµÐ¹ Ð³ÐµÑÐµÑÐ¾ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð° Ð² ÑÐ»ÑÑÐ°Ðµ Ð½Ð°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ CHD1. ÐÑ Ð¿ÑÐµÐ´Ð¿Ð¾Ð»Ð¾Ð¶Ð¸Ð»Ð¸, ÑÑÐ¾ Ð´Ð°Ð½Ð½ÑÐ¹ Ð¿ÑÐ¾ÑÐµÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ð°Ð½ Ñ Ð±ÐµÐ»ÐºÐ°Ð¼Ð¸ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Ð´Ð¾Ð·Ð¾Ð²Ð¾Ð¹ ÐºÐ¾Ð¼Ð¿ÐµÐ½ÑÐ°ÑÐ¸Ð¸ (MSL-ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ). ÐÐ¶Ð¸Ð´Ð°Ð»Ð¾ÑÑ, ÑÑÐ¾ ÑÐ²ÐµÑÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ CHD1 Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÑ Ðº ÑÐµÐºÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ MSL1 Ð¸Ð· Ð¥-ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ñ Ð² Ð¾Ð±Ð»Ð°ÑÑÑ ÑÑÐ¾Ð¼Ð¾ÑÐµÐ½ÑÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ðº Ð´ÐµÐºÐ¾Ð½Ð´ÐµÐ½ÑÐ°ÑÐ¸Ð¸ ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ñ 4. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ñ Ð¼ÐµÐ¶Ð´Ñ CHD1 Ð¸ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ¾Ð¼ MSL Ð½Ðµ Ð±ÑÐ»Ð° ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð°.
description: The given work is devoted to study of possible relationship between protein CHD1âs regulation of the structure of the X chromosome and the regulation of the structure of pericentromeric heterochromatin and of chromosome 4 chromatin in polytene chromosomes of salivary glands of D. melanogaster. CHD1 is a highly conservative ATP-dependent chromatin-remodeling factor engaged in important cellular processes in euchromatin. It was found that overexpression of catalytically inactive CHD1 or of wild-type CHD1 results in recruitment of this protein to the chromocenter, followed by decondensation of heterochromatin in the case of native CHD1. We assumed that this process is related to the proteins of the dosage compensation complex (MSL-complex). We proposed that overexpression of CHD1 could lead to recruitment of MSL1 from the X chromosome to the region of the chromocenter, as well as to decondensation of chromosome 4. In the course of work, the relationship between CHD1 and the MSL complex was not established.