cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Epidemiology of nosocomial infections in pediatric patients in an Iranian referral hospital
Creators: name: Pourakbari, B
name: Rezaizadeh, G
name: Mahmoudi, S
name: Mamishi, S
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Nosocomial infections (NI) are important causes of morbid- ity and mortality in pediatric hospitals. Different surveillance methods for detecting hospital-acquired infection have been developed. The selection of which varies according to specific surveillance objectives and the resources are available. The aim of this study was to determine the epidemiology of noso- comial infections in medical wards of a tertiary-levels teaching pediatric hospital in Tehran, Iran. We performed a prospective cross-sectional study and NI was identified by daily review of medical charts of patients hospitalized for at least 48 hours. We evaluated 1497 patients. The overall patient NI rate was 3.34 per 100 patients and the infection rate per 1000 patient-days was 5.27. The most common site of infection was the respira- tory tract (36%) followed by the gastrointestinal tract (32%). S. aureus, P. aeruginosa and Salmonella species were the most frequent pathogen isolates. The lethality rate associated with NI was 10%. Describing the epidemiology of NI in this hospi- tal enable us to estimate infection occurrence, distribution and expected incidence, as well as recognizing trends and keeping track of possible outbreaks.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 4 (2012)
title: Investigations on influenza A virus morphology
Creators: name: Goldfarb, Daniel Max
Publisher: name: University of Glasgow
Year: 2022

description: Clinical isolates of influenza A virus (IAV) typically form a pleomorphic population of virions that present as a continuum of morphologies broadly classified as filaments, bacilli, and spheres. Laboratory strains of IAV, however present mainly as spherical and bacilliform particles, suggesting a role for filaments in vivo. How these filaments form is not fully understood, but it has previously been shown that mutations in the viral matrix protein (M1) can be determinants of filament formation. In this work we show that filament formation also depends on multiple other genetic factors. To this end, we compared two IAV strains A/equine/Ohio/03 (O/2003) and A/equine/South Africa/4/03 (SA/2003) and found that SA/2003 could form filaments while O/2003 could not, despite no differences in their M1 sequences. To map the genetic basis of this difference, we generated reassortant viruses between O/2003 and SA/2003 and identified segments 1 (encoding polymerase basic protein 2, PB2), 4 (haemagglutinin, HA) and 6 (neuraminidase, NA) as determinants of morphology. We established that single mutations in segments 4 and 6, which alter the HA and NA proteins, alter virion morphology. To our surprise, we also identified three synonymous mutations in segment 1 of the virus that were determinants of filament formation despite not altering any known protein. We then extended this work to unravel the associated mechanisms of this change and found despite some differences in the activity of NA, contribution of HA to filament production, and differences in segment 1 RNA structure, there was no clear underlying mechanism. Given, that we were unable to identify the mechanisms associated with the change in morphology, we further extended this work to identify the factors involved in morphogenesis. To characterize IAV filament morphogenesis we employed cryogenic electron tomography (Cryo-ET) of vitrified equine fibroblasts (E. Derm). Although we were unable to identify any additional factors associated with IAV budding, we were able to generate a robust pipeline for studying filament formation. These results show that M1 is not the only determinant of IAV morphology, and that the ability to form filaments, a poorly studied but natural characteristic of IAV infection, is in fact modulated by multiple proteins and RNA determinants.
Supplementary document for High-efficient KYW acousto-optic Q-switch for a Ho:YAG laser - 5648987.pdf
Creators: name: Chizhikov, Alexander
name: Mukhin, Aleksey
name: Molchanov, Vladimir
name: Naumenko, Natalya
name: Egorov, Nikolay
name: Vorontsov, Konstantin
name: Yushkov, Konstantin
name: Zakharov, Nikita
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Environmental microbial contamination in dental setting: a local experience
Creators: name: Guida, Marco
name: GallÃ©, F
name: Di Onofrio, Valeria
name: Nastro, RA
name: Battista, M
name: Liguori, Giorgio
name: Battista, F
name: Liguori, Giorgio
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: ntroduction. Patients and operators are exposed during dental practice to an infective risk, which derives especially from micro- organisms suspended in aerosols. Environmental microbiologi- cal monitoring in dental settings represents a good instrument to detect critical situations.
Methods. In order to investigate environmental microbial contami- nation level in a local reality, we analyzed water, air and surfaces samples of a community-based dental facility by using protocol and threshold values proposed in a recent multicenter study carried out by the Italian Society of Hygiene, Preventive Medicine and Public Health (S.It.I.) working group ?Hygiene in Dentistry?. Microbial contamination was assessed in the same room for 4 non-consecu- tive weeks during all the five working days, before and at the end of the daily activity. Air was sampled also during clinical activity, through both active and passive sampling systems.
Results. Contamination of water showed a decrease during activ- ities, while a decrease in air contamination was registered only at the end of the day. Passive sampling values resulted more often above threshold values adopted. At the same time, surfaces con- tamination increases at the end of the activity. It seems that in the dental clinic analyzed microbial buildup represents the higher critical element. No differences have been registered among the different days of the week.
Discussion. Our study highlights the need to improve disinfection procedures and air treatment systems in the considered environ- ment. Microbiological monitoring could represent an important element to detect the presence of risk factors and to adopt control measures.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 4 (2012)
Functions of stress-induced lipid droplets in the nervous system.
Creators: name: Islimye, Eva
name: Girard, Victor
name: Gould, Alex P
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Model organisms
subject: Tumour Biology
subject: Genetics & Genomics
subject: Developmental Biology
subject: Stem Cells
subject: Metabolism

description: Lipid droplets are highly dynamic intracellular organelles that store neutral lipids such as cholesteryl esters and triacylglycerols. They have recently emerged as key stress response components in many different cell types. Lipid droplets in the nervous system are mostly observed in vivo in glia, ependymal cells and microglia. They tend to become more numerous in these cell types and can also form in neurons as a consequence of ageing or stresses involving redox imbalance and lipotoxicity. Abundant lipid droplets are also a characteristic feature of several neurodegenerative diseases. In this minireview, we take a cell-type perspective on recent advances in our understanding of lipid droplet metabolism in glia, neurons and neural stem cells during health and disease. We highlight that a given lipid droplet subfunction, such as triacylglycerol lipolysis, can be physiologically beneficial or harmful to the functions of the nervous system depending upon cellular context. The mechanistic understanding of context-dependent lipid droplet functions in the nervous system is progressing apace, aided by new technologies for probing the lipid droplet proteome and lipidome with single-cell type precision.
title: Modelling the Structures and Melting of Mg-Zn Alloys using Molecular Dynamics with Lennard-Jones Potentials
Creators: name: Limbu, Hemant Kumar
Publisher: name: University of Kent
Year: 2024

description: Molecular dynamics modelling has been used to study the Mg-Zn alloys in solid and molten states. GULP and DL_POLY simulation software simulated the crystal structure of Mg-Zn alloys at room temperature and highly disordered structures at melting temperatures.
The GULP has been used to validate the Lennard-Jones potential for the simulation. The GULP output energy minimisation showed almost the same values of cell parameters which are then used for input of the DL_POLY simulations. The Substitutional alloys have been simulated by creating a 4×4×4 supercell of 128 atoms of pure Mg using CrystalMaker, and substituting some Mg atoms with Zn atoms. The compression lattice strain caused by the substitution of dissimilar sizes of Mg and Zn has been studied. 

The DL_POLY simulation is run in an NPT ensemble with varying temperatures. It was obtained that the simulated melting temperatures of Pure Mg, α - Mg, Pure Zn, Mg51Zn20, Mg21Zn25, Mg4Zn7, MgZn2, and Mg2Zn11 are obtained at 1860K, 1820K, 1520K, 1740K, 1780K, 1860K, 1480K, and 1380K respectively. The experimental melting points of Pure Mg, α - Mg, Pure Zn, Mg51Zn20, Mg21Zn25, Mg4Zn7, MgZn2, and Mg2Zn11 are 923K, 910.87K, 692.58K, 621.4K, 822.47K, 851.93K, 862.93K, and 727.13K respectively. 

The investigation of cell parameters (a, b, c) for different Mg-Zn compounds have been done from 300K to 2300K. The simulated and computational values of densities at the molten state of Pure Mg, α - Mg, Pure Zn, Mg51Zn20, Mg21Zn25, Mg4Zn7, MgZn2, and Mg2Zn11 are calculated. 

The simulation of metal glass is studied by heating the alloys to 2500K using DL_POLY "bath" and quenching at the rate of 1013 K/s using DL_POLY "quench" in NPT. The study of the simulated metal glass showed the amorphous glassy atomic structure at room temperature for Pure Mg, α - Mg, Pure Zn, Mg51Zn20, Mg21Zn25, Mg4Zn7, MgZn2, and Mg2Zn11.

The surface melting of the alloys is investigated using DL_POLY in the NVT ensemble. The surface melting temperatures of Pure Mg, α - Mg, Pure Zn, Mg21Zn25, Mg4Zn7, MgZn2, Mg2Zn11 and Mg51Zn20 are obtained at 760K, 765K, 910K, 850K, 930K, 1000K,730K, and 500K respectively.
Supplementary document for High-efficient KYW acousto-optic Q-switch for a Ho:YAG laser - 5648987.pdf
Creators: name: Chizhikov, Alexander
name: Mukhin, Aleksey
name: Molchanov, Vladimir
name: Naumenko, Natalya
name: Egorov, Nikolay
name: Vorontsov, Konstantin
name: Yushkov, Konstantin
name: Zakharov, Nikita
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplement 1
An Open API Architecture to Discover the Trustworthy Explanation of Cloud AI Services
Creators: name: Wang, Zerui
name: Liu, Yan
name: Huang, Jun
Publisher: name: arXiv
Year: 2024
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Artificial Intelligence (cs.AI)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This article presents the design of an open-API-based explainable AI (XAI) service to provide feature contribution explanations for cloud AI services. Cloud AI services are widely used to develop domain-specific applications with precise learning metrics. However, the underlying cloud AI services remain opaque on how the model produces the prediction. We argue that XAI operations are accessible as open APIs to enable the consolidation of the XAI operations into the cloud AI services assessment. We propose a design using a microservice architecture that offers feature contribution explanations for cloud AI services without unfolding the network structure of the cloud models. We can also utilize this architecture to evaluate the model performance and XAI consistency metrics showing cloud AI services trustworthiness. We collect provenance data from operational pipelines to enable reproducibility within the XAI service. Furthermore, we present the discovery scenarios for the experimental tests regarding model performance and XAI consistency metrics for the leading cloud vision AI services. The results confirm that the architecture, based on open APIs, is cloud-agnostic. Additionally, data augmentations result in measurable improvements in XAI consistency metrics for cloud AI services.
description: Published in: IEEE Transactions on Cloud Computing ( Volume: 12, Issue: 2, April-June 2024)
Clinical presentation of meningococcal disease in childhood
Creators: name: Sabatini, C
name: Bosis, S
name: Semino, M
name: Senatore, L
name: Principi, N
name: Esposito, S
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Although relatively rare, meningococcal disease represents a global health problem being still the leading infectious cause of death in childhood with an overall mortality around 8%. Menin- gococcal meningitis is the most commonly recognized presenta- tion, accounting for 80% to 85% of all reported cases of menin- gococcal disease (in half of these cases sepsis is also present con- comitantly). The remaining 15-20% of cases are most commonly bloodstream infections only. Meningococcal serogroups A, B, and C account for most cases of meningococcal disease throughout the world. Recently, serogroups W-135 and X (predominantly in Africa) and group Y (in the United States and European countries) have emerged as important disease-causing isolates. Despite recent advances in medical management, the mortality rate of fulminant meningococcemia ranges from 15% to 30%. However, among survivors, 10-30% could have long term sequelae (i.e. sensoneural hearing loss, seizure, motor problems, hydrocepha- lus, mental retardation, and cognitive and behavioral problems). Considering the clinical severity of meningococcal disease, pre- vention represents the first approach for avoiding serious com- plications and possible deaths. The availability of new vaccines able to cover the emerging serotypes including A and Y as well as the availability on the market of new products that could prevent meningococcal B infection represent a great opportunity for the decrease of the burden of this complicated disease.
The full article is free available on www.jpmh.org
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 2 (2012)
Amastus mesorhoda Walker 1856
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Amastus
Amastus mesorhoda

description: Amastus mesorhoda Walker, 1856
Amastus mesorhoda Walker, 1856: 1704.
TYPE LOCALITY. — [Colombia], [Cundinamarca], Bogotá.
TYPE SPECIMENS. — Undisclosed number of female syntypes (UMO; one specimen labeled TYPE).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 300, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Surveillance and evidence of contamination in hospital environment from meticillin and vancomycin-resistant microbial agents
Creators: name: Squeri, Raffaele
name: Grillo, Orazio Claudio
name: La Fauci, Vincenza
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Introduction. Direct contact is undoubtedly the main means of transmission of hospital infections. An investigative study was therefore conducted to assess workplace surfaces at risk from microbial contamination.
Methods. The study was conducted using swabs and contact slides placed on the palms of healthcare workers during their routine patient care and on workplace surfaces (e.g. telephones, computers, medication trolleys, taps) in treatment rooms, oper- ating theatres and wards. Disposable swabs were used for rapid screening and read with a bioluminometer. At the same time, a sample was taken from those testing positive using a contact slide. The samples testing positive for Staphylococci underwent identification to assess resistance to meticillin-resistant Sta- phylococcus aureus (MRS/MRSA) and to vancomycin (VISA/ VRSA)
Results. Meticillin-resistant Staphylococcus strains were found on 14.7% (20/136) of samples taken from the hands of workers and 35.7% (15/42) of those from hospital surfaces. An even higher resistance to meticillin and/or vancomycin than that found for S. aureus was identified in nosocomial strains of coagulase negative staphylococci, including S. epidermidis and S. haemolyticus. Conclusion. The study concludes that there is thus a need for greater care in complying with procedures designed and support for surveillance to reduce the risk of infection.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 3 (2012)
Out of the Silence: Insights into How Genes Escape X-Chromosome Inactivation
Creators: name: Peeters, Samantha B.
name: Posynick, Bronwyn J.
name: Brown, Carolyn Janet
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2024

description: The silencing of all but one X chromosome in mammalian cells is a remarkable epigenetic process leading to near dosage equivalence in X-linked gene products between the sexes. However, equally remarkable is the ability of a subset of genes to continue to be expressed from the otherwise inactive X chromosome—in some cases constitutively, while other genes are variable between individuals, tissues or cells. In this review we discuss the advantages and disadvantages of the approaches that have been used to identify escapees. The identity of escapees provides important clues to mechanisms underlying escape from XCI, an arena of study now moving from correlation to functional studies. As most escapees show greater expression in females, the not-so-inactive X chromosome is a substantial contributor to sex differences in humans, and we highlight some examples of such impact.
Prevalence and intensity of intestinal helminthiasis in children living in orphanages in Benin City, Nigeria
Creators: name: Nwaneri, DU
name: Omuemu, VO
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Background. Orphans may be envisaged to have sub-optimal care and may be predisposed to high worm burden. This study was under- taken to determine prevalence and intensity of intestinal helminthi- asis in children living in orphanages in Benin City, Nigeria. Methods. Fresh stool samples from 150 children (0-17 years) living in 10 orphanages in Benin City, were analyzed using the Kato-Katz technique for the detection of ova of helminths between January and April, 2011.
Results. The subjects consisted of 62 (41.3%) males and 88 (58.7%) females; mean age (Â± standard deviation SD) 7.0 Â± 4.6 years, and mean (Â± SD) years lived in the orphanage was 4.0 Â± 3.7 years. Prevalence of intestinal helminthiasis was 20.7% and this prevalence was highest in children ages 12-17 years, children who had lived longer years in the orphanages and in orphanages with poor child/care-giver ratio (orphanage F = 12.0: 1 and orphan- age H = 7.3: 1). Mean (Â± SD) age (8.7 Â± 4.5 years) of infected subjects was significantly higher than (6.6 Â± 4.5 years) observed in non-infected subjects (p = 0.023). Ascaris lumbricoides and Trichuris trichiura were the intestinal helminths isolated. Inten- sity of intestinal helminths was light in 24/31 (77.4%) and moder- ate in 7/31 (22.6%) infected subjects. Median egg per gram was 999 eggs per gram and range was 48-8000.
Conclusion. Improved child/care-giver ratio in orphanages will reduce worm burden in orphanages in Benin City.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 3 (2012)
Supplementary document for Single-frequency orbital angular momentum switchable modes from a microchip laser - 6986516.pdf
Creators: name: Li, Chen
name: Hua, Ziyu
name: Wang, Qing
name: li, lang
name: zhang, zhichao
name: Hai, Lan
name: Tan, Yidong
name: Gao, Chunqing
name: Fu, Shiyao
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplementary Details
Teaching English as a Second Language in the Early Years: Teachers’ Perspectives and Practices in Finland
Creators: name: Koyuncu, Selma
name: Kumpulainen, Kristiina
name: Kuusisto, Arniika
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2024

description: Second language (L2) education in the early years has been steadily increasing worldwide. Since second language education at earlier ages is relatively new in many countries, not much research is available regarding teaching practices in this context. Likewise, limited research attention has been directed to teachers’ perspectives on early L2 teaching. This study investigated what characterises teachers’ pedagogical planning, teaching practices and assessment of language learning, and teachers’ perspectives about the opportunities and challenges in early L2 classrooms within the cultural context of the Finnish education system. The data for this study were gathered through an online survey involving teachers of English (n = 49) as a second language in the early years of primary education in Finland. The results show that the teachers based their pedagogical planning on the curriculum, used a variety of L2 tasks and materials, which they often prepared by themselves, and they mostly used observation, instead of formal exams, for assessing the children’s learning in L2. The results revealed that the teachers’ perspectives to the early start for L2 teaching were positive, which stemmed from the children’s enthusiasm for language learning. The teachers draw attention to challenges such as big group sizes, the diversity in children’s skills (e.g., their prior L2 knowledge, social skills, learning capabilities), and the limited availability of teaching materials targeted for young learner groups in L2 education. The findings demonstrate the opportunities and challenges L2 teachers of early learners face in Finland.
Amastus ambrosia
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Amastus
Amastus ambrosia

description: Amastus ambrosia (Druce, 1890)
Phaegoptera ambrosia Druce, 1890b: 498.
Amastus peralta Seitz, 1925: 418. — Type locality: Colombia, [Tolima], Monte Tolima. — Type specimens: Undisclosed number of syntypes (SMF; one male syntype labeled TYPUS).
Amastus thermidora Dognin, 1913: 4. — Type locality: Ecuador, [Loja], environs de Loja. — Type specimen: Holotype female no. 30 404 (USNM).
TYPE LOCALITY. — [Colombia], Antioquia, Frontino.
TYPE SPECIMENS. — Undisclosed number of syntypes (BMNH; one female syntype labeled TYPE).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 300, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Antimicrobial efficacy and longevity of Silver+zeolite incorporating preinsulated ducts installed in real healthcare settings
Creators: name: Tinteri, C
name: Potenza, M
name: Rizzetto, R
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Objective. The values of microbial growth in the air exiting from the Heating, Ventilation and Air Conditioning (HVAC) ducts treated with silver/zeolite have been shown to be lower than those in the air coming out the traditional metal ones.This study aims to verify how long this antimicrobial activity lasts.
Methods. All the tests were performed according to US ASTM E2180-01 and ISO-JIZ 22196 standards. Samples of aluminum cladding panels of different thickness and incorporating silver- zeolite were tested in order to verify their thickness depending antibacterial activity. The same kind of linings samples were analyzed after a simulated and accelerated ageing process. Ag- zeolite incorporating HVAC duct panels linings were tested after years from their installation, in order to verify the maintenance of their bactericidal power during time.
Results and conclusions. For laminates containing different amounts of silver+Zeolite it was shown that also in panels with minimum thickness tested, the lowest germicidal effect (GE) found was still very good (GE of 5,76 ULog10). After their wearing and tearing the antimicrobial activity tended to increase passing from 7.2081 to 8.29922 LogUnits in panels 80microns thick. For still hos- pital working aluminium foils incorporatig Silver/Zeolite on panels installed through 2006 and 2008, the antimicrobial action of zeolite was still firmly present even after two years and three years.The germicidal effect standards were maintained even during time on constant values between 7.477 and 7.086 LogUnits. The persistence of bactericidal efficacy of Ag+zeolite treatment in all the materials used for the construction of HVAC ductworks can be confirmed.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 4 (2012)
Supplementary document for Development and ex-vivo validation of 36G polyimide cannulas integrating a guiding miniaturized OCT probe for robotic assisted subretinal injections - 5649364.pdf
Creators: name: Abid, Alexandre
name: Duval, Renaud
name: Boutopoulos, Christos
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Photodetectors, Optical Sensors and Solar Cells
Ophthalmology

description: Figure S1
The clinical features and estimated incidence of MIS-C in Cape Town, South Africa.
Creators: name: Butters, Claire
name: Abraham, Deepthi Raju
name: Stander, Raphaella
name: Facey-Thomas, Heidi
name: Abrahams, Debbie
name: Faleye, Ayodele
name: Allie, Nazneen
name: Soni, Khushbu
name: Rabie, Helena
name: Scott, Christiaan
name: Zühlke, Liesl
name: Webb, Kate
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Genetics & Genomics
subject: Model organisms
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational & Systems Biology

description: BACKGROUND: Multisystem inflammatory syndrome is a severe manifestation of SARS-CoV-2 in children. The incidence of MIS-C after infection is poorly understood. There are very few cohorts describing MIS-C in Africa despite MIS-C being more common in Black children worldwide. METHODS: A cohort of children with MIS-C and healthy children was recruited from May 2020 until May 2021 from the two main paediatric hospitals in Cape Town, South Africa. Clinical and demographic data were collected, and serum was tested for SARS-CoV-2 antibodies. The incidence of MIS-C was calculated using an estimation of population exposure from seroprevalence in the healthy group. Summary data, non-parametric comparisons and logistic regression analyses were performed. RESULTS: Sixty eight children with MIS-C were recruited with a median age of 7 years (3.6, 9.9). Ninety seven healthy children were recruited with a 30% seroprevalence. The estimated incidence of MIS-C was 22/100 000 exposures in the city in this time. Black children were over-represented in the MIS-C group (62% vs 37%, p = 0.002). The most common clinical features in MIS-C were fever (100%), tachycardia (98.5%), rash (85.3%), conjunctivitis (77.9%), abdominal pain (60.3%) and hypotension (60.3%). The median haemoglobin, sodium, neutrophil count, white cell count, CRP, ferritin, cardiac (pro-BNP, trop-T) and coagulation markers (D-dimer and fibrinogen) were markedly deranged in MIS-C. Cardiac, pulmonary, central nervous and renal organ systems were involved in 71%, 29.4%, 27.9% and 27.9% respectively. Ninety four percent received intravenous immune globulin, 64.7% received methylprednisolone and 61.7% received both. Forty percent required ICU admission, 38.2% required inotropic support, 38.2% required oxygen therapy, 11.8% required invasive ventilation and 6% required peritoneal dialysis. Older age was an independent predictor for the requirement for ionotropic support (OR = 1.523, CI 1.074, 2.16, p = 0.018). The median hospital stay duration was 7 days with no deaths. CONCLUSION: The lack of reports from Southern Africa does not reflect a lack of cases of MIS-C. MIS-C poses a significant burden to children in the region as long as the pandemic continues. MIS-C disproportionately affects black children. The clinical manifestations and outcomes of MIS-C in this region highlight the need for improved surveillance, reporting and data to inform diagnosis and treatment.
Prevalence of sexually transmitted infections and enteric protozoa among homosexual men in western Sicily (south Italy)
Creators: name: Di Benedetto, MA
name: Di Piazza, F
name: Amodio, Emanuele
name: Taormina, S
name: Romano, Ferdinando
name: Firenze, Alberto
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Introduction. In recent years an increase in the number of sexu- ally transmitted infections (STIs) in men who have sex with men (MSM) has been reported in different industrialised countries. Because few epidemiological data on the STIs/MSM population in Sicily are available, a survey was conducted to assess the preva- lence of STIs/enteric protozoa and risky sexual behaviours among MSM in western Sicily.
Methods. In 2010, 74 MSM with median age of 30 years old, were recruited via networks. All participants to the study were interviewed by anonymous self-administered questionnaire in order to collect social/demographic information, clinic data and STI-related risky sexual behaviours. After completing the ques- tionnaire, blood samples were collected to determine HIV, HCV, HHV8 and Treponema pallidum antibodies; presence of Giardia duodenalis and Cryptosporidium parvum was also investigated in faecal samples by immunofluorescence assay.
Results. HIV, HHV8, T. pallidum and Giardia prevalence were 8.1%, 16.2%, 21.6% and 16.4% respectively; all patients were negative for HCV and Cryptosporidium infections. The median values of sexual anal intercourse and oral sex per week were 2 and 1, respectively. 7% of participants always had unprotected anal sex, 50.7% sometimes used condom during sexual anal inter- course and 42.3% always had protected anal sex. All MSM-HIV+ and 7 (43.7%) syphilis seropositives were unaware of their own infection.
Discussion. MSM in western Sicily are a high risk group for important STIs. It seems necessary that continuous interventions for preventing HIV/AIDS and other STIs and for improving the level of knowledge of symptoms are needed.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 4 (2012)
The prevalence and antibiotics susceptibility pattern of Neisseria gonorrhoeae in patients attending OPD clinics at St. Mary?s Hospital Lacor Uganda
Creators: name: Amito Florence, P
name: Otim, F
name: Okongo, F
name: Ogwang, M
name: Greco, D
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Introduction. Gonorrhea is one of the most common sexually transmitted infections (STIs) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gon- orrhoeae is a major obstacle in the control of gonorrhoea. Peri- odical determination of the prevalence and monitoring of antimi- crobial susceptibility of N. gonorrhoeae is essential for the early detection of emergence of drug resistance.
Methods. A total of 640 consecutive patients who attended the Outpatient Department (OPD) Clinics at St. Mary?s Hospital Lacor between Jan 2007-Dec 2011, with gonococcal urethri- tis symptoms and whose urethral swabs and high vagina swabs (HVS) were cultured, were involved in the study. Two hundred and fifty six (256) patients had positive pus swab culture, of which 151 (23.6%) showed growth of Neisseria gonorrhoeae. All the isolates were tested for antimicrobial susceptibility using the Kirby Bauer-Disc diffusion techniques.
Results. Gonococcal isolates showed rapid decrease in suscepti- bility to the antimicrobials especially to Ampicillin, Tetracycline and Erythomycin, Ciprofloxacin, and intermediate to chloram- phenicol, however, Gentamicin and cefotaxime have remained as a single dose sensitive treatment for Neisseria gonorrhoeae. Sen- sitization on drug use and adopting preventive measures and con- tinuous education on safer sexual behavior through health care authorities would lead to reduction in the prevalence of Neisseria gonorrhoeae and resistance to antimicrobial.
Discussion. Gonorrhea is one of the most common sexually trans- mitted infections (STIs) in developing countries, and the emer- gence of resistance to antimicrobial agents in Neisseria gonor- rhoeae is a major obstacle in the control of gonorrhea. Periodi- cal monitoring of antimicrobial susceptibility of N. gonorrhea is essential for the early detection of emergence of drug resistance.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 4 (2012)
Erneuerbare Energien in Deutschland 2018
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: subject: Erneuerbare Energien
subject: Arbeitsgruppe Erneuerbare Energien-Statistik
subject: AGEE-Stat
subject: Klima | Energie

description: Die Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat), die im Auftrag des Bundesministeriums für Wirtschaft und Energie regelmäßig die Nutzung der erneuerbaren Energien bilanziert, hat auf der Grundlage verfügbarer, zumeist vorläufiger Daten eine erste Abschätzung zur Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2018 erstellt. Das vorliegende Hintergrundpapier beschreibt die bisherigen Erkenntnisse für die Bereiche Strom, Wärme und Verkehr, ergänzt um Zahlen zur Emissionsvermeidung durch erneuerbare Energien. Quelle: Verlagsinformation
description: Die Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat), die im Auftrag des Bundesministeriums für Wirtschaft und Energie regelmäßig die Nutzung der erneuerbaren Energien bilanziert, hat auf der Grundlage verfügbarer, zumeist vorläufiger Daten eine erste Abschätzung zur Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2018 erstellt. Das vorliegende Hintergrundpapier beschreibt die bisherigen Erkenntnisse für die Bereiche Strom, Wärme und Verkehr, ergänzt um Zahlen zur Emissionsvermeidung durch erneuerbare Energien.
Supplementary document for Development and ex-vivo validation of 36G polyimide cannulas integrating a guiding miniaturized OCT probe for robotic assisted subretinal injections - 5649364.pdf
Creators: name: Abid, Alexandre
name: Duval, Renaud
name: Boutopoulos, Christos
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Photodetectors, Optical Sensors and Solar Cells
Ophthalmology

description: Figure S1
Amastus phaeosoma Hampson 1901
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Amastus
Amastus phaeosoma

description: Amastus phaeosoma Hampson, 1901
Amastus phaeosoma Hampson, 1901a: 136.
TYPE LOCALITY. — Peru (!), [Pichincha], Quito.
TYPE SPECIMEN. — Holotype female (BMNH).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 301, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Search for pair production of third-generation leptoquarks decaying into a bottom quark and a τ -lepton with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: Springer Berlin Heidelberg
Year: 2024

description: A search for pair-produced scalar or vector leptoquarks decaying into a b-quark and a τ -lepton is presented using the full LHC Run 2 (2015–2018) data sample of 139 fb−1 collected with the ATLAS detector in proton– proton collisions at a centre-of-mass energy of √s = 13 TeV. Events in which at least one τ -lepton decays hadronically are considered, and multivariate discriminants are used to extract the signals. No significant deviations from the Standard Model expectation are observed and 95% confidencelevel upper limits on the production cross-section are derived as a function of leptoquark mass and branching ratio B into a τ -lepton and b-quark. For scalar leptoquarks, masses below 1460 GeV are excluded assuming B = 100%, while for vector leptoquarks the corresponding limit is 1650 GeV (1910 GeV) in the minimal-coupling (Yang–Mills) scenario.
Neisseria meningitidis: pathogenetic mechanisms to overcome the human immune defences
Creators: name: Gasparini, Roberto
name: Amicizia, Daniela
name: Lai, Piero Luigi
name: Panatto, Donatella
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Neisseria meningitidis is hosted only by humans and colonizes the nasopharynx; it survives in the human body by reaching an equilibrium with its exclusive host. Indeed, while cases of invasive disease are rare, the number of asymptomatic Neisseria menin- gitides carriers is far higher. The aim of this paper is to sum- marize the current knowledge of survival strategies of Neisseria meningitides against the human immune defences. Neisseria meningitidis possesses a variety of adaptive character- istics which enable it to avoid being killed by the immune system, such as the capsule, the lipopolysaccharide, groups of proteins that block the action of the antimicrobial proteins (AMP), pro- teins that inhibit the complement system, and components that prevent both the maturation and the perfect functioning of phago- cytes. The main means of adhesion of Neisseria meningitides to the host cells are Pili, constituted by several proteins of whom the most important is Pilin E. Opacity-associated proteins (Opa) and (Opc) are two proteins that make an important contribution to the process of adhesion to the cell. Porins A and B contribute to neisserial adhesion and penetration into the cells, and also inhibit the complement system. Factor H binding protein (fhbp) binds factor H, allowing the bac- teria to survive in the blood. Neisserial adhesin A (NadA) is a minor adhesin that is expressed by 50% of the pathogenic strains. NadA is known to be involved in cell adhesion and invasion and in the induction of proinflam- matory cytokines. Neisserial heparin binding antigen (NHBA) binds heparin, thus increasing the resistance of the bacterium in the serum. The full article is free available on www.jpmh.org
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 2 (2012)
Synthesis and photolytic assessment of nitroindolinyl-caged calcium ion chelators
Creators: name: Papageorgiou, George
name: John ET Corrie
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Chemical Biology & High Throughput
Structural Biology & Biophysics

description: Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.
A combined approach to assess the potential coverage of a multicomponent protein-based vaccine
Creators: name: Boccadifuoco, G
name: Brunelli, B
name: Pizza, MG
name: Giuliani, Anna Rita
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Meningococcal disease caused by Neisseria meningitidis sero- group B is a public health concern even in developed countries. Despite glycoconjugate vaccines against the other invasive sero- groups (A, C, W135, Y) are already available and successfully introduced in many countries, no vaccine is currently in use for prevention of serogroup B meningitis.
A protein based, multicomponent vaccine (4CMenB) has been developed and proposed for prevention of invasive serogroup B meningococcal disease (MenB). This novel vaccine has been tested in clinical trials and shown to be well tolerated and immunogenic, inducing bactericidal antibodies in infants, adolescents and adults. The high level of genetic and antigenic variability observed in MenB clinical isolates, requires a suitable method to assess the ability of the 4CMenB vaccine to cover genetically diverse menig- ococcal strains and to estimate the potential public health impact. To this purpose the Meningococcal Antigen Typing System (MATS) has been developed and recently described. This method provides a quick and reproducible tool to estimate the level of expression and immunoreactivity of each of the vaccine antigens, in any meningococcal isolate, and it is related to the likelihood that the isolate will be killed by sera from immunized subjects.
A multi-laboratory study involving several European countries, demonstrates that the 4CMenB has the potential to protect against a significant proportion of menB strains circulating in Europe.
The full article is free available on www.jpmh.org
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 2 (2012)
Amastus volcancita Dognin 1911
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Amastus
Amastus volcancita

description: Amastus volcancita Dognin, 1911
Amastus volcancita Dognin, 1911c: 10.
TYPE LOCALITY. — Colombia, Quindin, Volcancito.
TYPE SPECIMEN. — Holotype female no. 30 401 (USNM).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 301, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
A phase II, randomised clinical trial to demonstrate the non-inferiority of low-dose MF59Â®-adjuvanted pre-pandemic A/H5N1 influenza vaccine in adult and elderly subjects
Creators: name: Czajka, H
name: Unal, S
name: Ulusoy, S
name: Usluer, G
name: Strus, A
name: Sennaroglu, E
name: Guzik, J
name: Topeli Iskit, A
name: Dargiewicz, A
name: Musial, D
name: Caylan, R
name: Dziduch, J
name: Eskioglu, E
name: Hasiec, B
name: Cwinarowiczliwa, E
name: Belli, R
name: Abdel-Messih, IA
name: Beygo, J
name: Fragapane, E
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: ackground. Effective planning and preparedness against a possi- ble future A/H5N1 influenza pandemic is a major global challenge. Because dose sparing strategies are required to meet the global demand for vaccine, efforts have focused on the development of adju- vanted vaccine formulations of relatively lower antigen content. Aim. This study aimed to demonstrate the non-inferiority of a low-antigen-dose (3.75 mg) A/H5N1 pre-pandemic vaccine com- pared with a licensed, higher-dose (7.5 mg) formulation in adult and elderly subjects. Immunogenicity was assessed according to European and U.S. licensure criteria.
Methods. A total of 722 subjects were randomized in equal num- bers to receive either the licensed or low-dose formulation. All subjects received two vaccine doses administered three weeks apart. Immunogenicity was assessed three weeks after the admin- istration of each vaccine dose by hemagglutination inhibition HI), single radial haemolysis (SRH) and microneutralization assays (MN). Local and systemic reactions were assessed over a seven day period post-vaccination. Adverse events were recorded throughout.
Results. The low-dose vaccine was demonstrated to be non-infe- rior to the licensed formulation in terms of antibody titres against the vaccine strain. All three European licensure criteria were met by adult subjects in response to the low-dose vaccine; two crite- ria were met by the elderly age group. Cross-reactive antibodies were detected against the heterologous A/H5N1 antigen strains A/Indonesia/05/05 and A/turkeyTurkey/01/05. Both vaccines were generally well tolerated by both age groups.
Conclusion. These data demonstrate that a low antigen dose in combination with MF59Â® adjuvant is adequate for the routine pre-pandemic immunization of adult and elderly subjects.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 3 (2012)
Behind the Scenes: Insights on Pedagogy during Implementation of an RbT Open Educational Resource
Creators: name: Cox, Susan M.
name: Smithdeal, Matthew
name: Lee, Michael
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2024

description: Research-based Theatre (RbT) offers a powerful stimulus for dialogue about the challenges of graduate supervisory relationships. This paper traces the implementation process for Rock the Boat, an open-access educational resource that includes four professionally acted scenes, a facilitator’s guide, and supplementary reading materials. The resource has been used extensively in online, in-person, and hybrid workshops to identify difficulties in graduate supervision, heighten awareness of power dynamics, and increase reflective practice among participants. Reflecting on lessons learned about the importance of pedagogy and practical logistics, we suggest that implementation aspects of RbT methodology are as vital as the creative and developmental.
Is Venice an ideal habitat for Legionella pneumophila?
Creators: name: Ziprani, C
name: Selle, V
name: Palazzi, B
name: Capretta, F
name: Ghio, L
name: Flora, ME
name: Baldo, Vincenzo
Publisher: name: Department of Health Science - University of Genoa
Year: 2012

description: Introduction. Legionella bacterium manifests itself in Legion- naire?s disease and Pontiac fever, it is mainly found and trans- mitted by aerosol produced in cooling towers, water distribution plants and medical equipment, and it affects mainly elder persons in poor health.
Methods. The population of Venice Local Health Unit was divided in two areas of study and the incidence of legionellosis in residents of Venice historical centre (Distretto Sanitario 1) and in residents of the mainland and coastal areas (Distretti Sanitari 2, 3, 4) was calculated. The cases were those notified to the Public Health Unit by law, and the population of residents was that of the eligible for health care in the archives of the Local Health Unit. Only cases of legionellosis in residents who had not travelled in the 10 days previous of the onset of disease, and not related to nosocomial clusters were considered. The standardized incidence ratio was then calculated and confidence interval were defined by Poisson distribution.
Results. Given the population of the two areas, 59801 in Distretto Sanitario 1 and 237555 in Distretti 2, 3, 4, the raw incidence of disease is respectively 87 per 100000 and 20 per 100000 in time 2002-2010. The standardized incidence ratio for the population of Distretto Sanitario 1 vs the remaining population is 4.3. Discussion. The difference in risk of getting the disease in this two residential areas geographically very close, is probably related to the different buildings? characteristics, old and difficult to main- tain in Venice historical centre.
description: Journal of Preventive Medicine and Hygiene, Vol 53, No 3 (2012)