cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cost-minimization analysis of alemtuzumab compared to fingolimod and natalizumab for the treatment of active relapsing-remitting multiple sclerosis in the Netherlands
Creators: name: M. A. Piena
name: M. Heisen
name: L. W. Wormhoudt
name: J. Van Wingerden
name: S. T. F. M. Frequin
name: B. M. J. Uitdehaag
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aim: In active relapsing remitting multiple sclerosis (RRMS) patients requiring second-line treatment, the Dutch National Health Care Institute (ZiN) has not stated a preference for either alemtuzumab, fingolimod, or natalizumab. The aim was to give healthcare decision-makers insight into the differences in cost accumulation over time between alemtuzumab—with a unique, non-continuous treatment schedule—and fingolimod and natalizumab for second-line treatment of active RRMS patients in the Netherlands. Methods: In line with ZiN’s assessment, a cost-minimization analysis was performed from a Dutch healthcare perspective over a 5-year time horizon. Resource use was derived from hospital protocols and summaries of product characteristics, and validated by two MS specialists. Unit costs were based on national tariffs and guidelines. Robustness of the base case results was verified with multiple sensitivity and scenario analyses. Results: Alemtuzumab results in cost savings compared to fingolimod and natalizumab from, respectively, 3.3 and 2.8 years since treatment initiation onwards. At 5 years, total discounted costs per patient of alemtuzumab were €79,717, followed by fingolimod with €110,044 and natalizumab with €122,238, resulting in cost savings of €30,327 and €42,522 for alemtuzumab compared to fingolimod and natalizumab, respectively. Key drivers of the model are drug acquisition costs and the proportions of patients that do not require further alemtuzumab treatment after either two, three, or four courses. Limitations: No treatment discontinuation and associated switching between treatments were incorporated. Consequences of JC virus seropositivity while continuing natalizumab treatment (e.g. additional monitoring) were omitted from the base case. Conclusion: The current cost-minimization analysis demonstrates that, from the Dutch healthcare perspective, treating active RRMS patients with alemtuzumab results in cost savings compared to second-line alternatives fingolimod and natalizumab from ∼3 years since treatment initiation onwards. After 5 years, alemtuzumab’s cost savings are estimated at €30k compared to fingolimod and €43k compared to natalizumab.
title: ADCO, Cartulaire des Dominicains de Dijon (1286), Cart. 221 (H 53), 170 folios, f. 0025
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios, f. 0025, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
A precise, sensitive and stable LC-MSMS method for detection of picomolar levels of serum aldosterone
Creators: name: Lie, Margrete
name: Thorstensen, Ketil
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: Plant Biology

description: Background: Accurate quantification of aldosterone is essential in the diagnosis of primary aldosteronism. Liquid chromatography-tandem mass spectrometry (LC-MSMS) analysis is increasingly being used to improve analytical sensitivity and specificity, since this technology reduces most of the interferences observed with immunological methods. Methods: Serum samples with d7-aldosterone as internal standard were extracted with methyl tert-butyl ether, using liquid-liquid extraction (LLE). Chromatographic separation was performed on a C18 reverse phase column with a methanol-water gradient containing ammonium fluoride. Aldosterone detection was performed on an Agilent 6490 triple quadrupole using electro spray ionisation in positive mode. Results: Multiple reaction monitoring transitions were m/z 361.2–315.1 for aldosterone, and 368.5–323.3 for d7-aldosterone. Chromatographic retention time was 2.7 min. The method’s total CVs at aldosterone concentrations of 45.4 and 1080 pmol/L were 7.0% and 4.8%, respectively. The intra-assay CVs at concentrations of 60.0 and 637 pmol/L were 4.0% and 2.6%, respectively. The method’s LOQ and LOD were 10 and 5 pmol/L, respectively, demonstrating an excellent analytical sensitivity. The upper limit of quantification was set to 5000 pmol/L, corresponding to the highest calibrator concentration. The long-term stability of the method was evident from repeated measurements of external control pools from UKNEQAS over a period of about 3 years, showing CVs between 2.0 and 7.0%. Conclusions: We have described a precise, sensitive and stable LC-MSMS method for the measurement of serum aldosterone. In addition, due to the use of LLE and a short LC-column, the method is simple to perform, with a short chromatographic run time.
Keck/Palomar Cosmic Web Imagers (KCWI/PCWI) Reveal an Enormous Ly$α$ Nebula in an Extremely Overdense QSO Pair Field at $z=2.45$
Creators: name: Cai, Zheng
name: Hamden, Erika
name: Matuszewski, Matt
name: Prochaska, J. Xavier
name: Li, Qiong
name: Cantalupo, Sebastiano
name: Battaia, Fabrizio Arrigoni
name: Martin, Christopher
name: Neill, James D.
name: O'Sullivan, Donal
name: Wang, Ran
name: Moore, Anna
name: Morrissey, Patrick
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Enormous Ly$α$ nebulae (ELANe) represent the extrema of Ly$α$ nebulosities. They have detected extents of $>200$ kpc in Ly$α$ and Ly$α$ luminosities $>10^{44}$ erg s$^{-1}$. The ELAN population is an ideal laboratory to study the interactions between galaxies and the intergalactic/circumgalactic medium (IGM/CGM) given their brightness and sizes. The current sample size of ELANe is still very small, and the few $z\approx2$ ELANe discovered to date are all associated with local overdensities of active galactic nuclei (AGNs). Inspired by these results, we have initiated a survey of ELANe associated with QSO pairs using the Palomar and Keck Cosmic Web Imagers (PCWI/KCWI). In this letter, we present our first result: the discovery of ELAN0101+0201 associated with a QSO pair at $z=2.45$. Our PCWI discovery data shows that, above a 2-$σ$ surface brightness of $1.2\times10^{-17}$ \sbunit, the end-to-end size of ELAN0101+0201 is $\gtrsim 232$ kpc. We have conducted follow-up observations using KCWI, resolving multiple Ly$α$ emitting sources within the rectangular field-of-view of $\approx 130\times165$ projected kpc$^2$, and obtaining their emission line profiles at high signal-to-noise ratios. Combining both KCWI and PCWI, our observations confirm that ELAN0101+0201 resides in an extremely overdense environment. Our observations further support that a large amount of cool ($T\sim10^4$K) gas could exist in massive halos (M$\gtrsim10^{13}$M$_\odot$) at $z\approx2$. Future observations on a larger sample of similar systems will provide statistics of how cool gas is distributed in massive overdensities at high-redshift and strongly constrain the evolution of the intracluster medium (ICM).
description: Submitted to Astrophysical Journal Letter, 9 pages, 4 figures, Comments Welcome
Threshold Effects on Heavy Quark Production in $γγ$ Interactions
Creators: name: Eboli, O. J. P.
name: Gonzalez-Garcia, M. C.
name: Halzen, F.
name: Novaes, S. F.
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The exchange of gluons between heavy quarks produced in $e^+e^-$ interactions results in an enhancement of their production near threshold. We study QCD threshold effects in $γγ$ collisions. The results are relevant to heavy quark production by beamstrahlung and laser back-scattering in future linear collider experiments. Detailed predictions for top, bottom and charm production are presented.
description: 26 pages, 12 figures available in ps upon request, revtex, MAD/PH/701 (revised version)
Implications of Particle Acceleration in Active Galactic Nuclei for Cosmic Rays and High Energy Neutrino Astronomy
Creators: name: Szabo, A. P.
name: Protheroe, R. J.
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We consider the production of high energy neutrinos and cosmic rays in radio-quiet active galactic nuclei (AGN) or in the central regions of radio-loud AGN. We use a model in which acceleration of protons takes place at a shock in an accretion flow onto a supermassive black hole, and follow the cascade that results from interactions of the accelerated protons in the AGN environment. We use our results to estimate the diffuse high energy neutrino intensity and cosmic ray intensity due to AGN. We discuss our results in the context of high energy neutrino telescopes under construction, and measurements of the cosmic ray composition in the region of the ``knee'' in the energy spectrum at $\sim 10^7$ GeV.
description: 37 pages of compressed and uuencoded postscript; hardcopy available on request; to be published in Astroparticle Physics; ADP-AT-94-4
Approximation of common fixed points of strongly nonexpansive sequences in a Banach space
Creators: name: Aoyama, Koji
name: Toyoda, Masashi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47H09, 47H10, 41A65

description: The aim of this paper is to establish a strong convergence theorem for a strongly nonexpansive sequence in a Banach space. We also deal with some applications of the convergence theorem.
description: 13 pages
HUKUMAT FAOLIYATINI TARTIBGA SOLISHNING HUQUQIY ASOSLARI HAMDA IXCHAMLASHTIRISH BO'YICHA AMALGA OSHIRILGAN ISHLAR TAHLILI
Creators: name: Sobitov, Ilxomjon
Publisher: name: Zenodo
Year: 2024

description: Davlatning muayyan funksiyasini amalga oshiradigan har qanday hokimiyat tarmog‘i bo‘lsin o‘z vazifalari va vakolatlarini qandaydir bir faoliyatini tartibga solinishini ta’minlovchi huquqiy hujjat asosida faoliyat olib boradi. Bularga misol sifatida mamlakatimizning qonun chiqaruvchi organi – Oliy Majlis ham “O‘zbekiston Respublikasining Senati to‘g‘risida”gi va “O‘zbekiston Respublikasining Qonunchilik Palatasi to‘g‘risida”gi Konstitutsiyaviy qonunlari asosida faoliyat ko‘rsatadi. Davlat hokimiyatining mustaqil tarmog‘i bo‘lgan sud hokimiyati esa “Sudlar to‘g‘risida”gi va “O‘zbekiston Respublikasining Konstitutsiyaviy Sudi to‘g‘risida”gi Konstitutsiyaviy qonuni asosida o‘z faoliyatining huquqiy asosi sifatida ish yuritib kelmoqda.
An Exploration Of Falls-Risk After Stroke: A Mixed Methods Approach
Creators: name: Walsh, Mary Elizabeth
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: This thesis aimed to inform the assessment of post-stroke falls-risk in those discharged to the community. It comprised five inter-linked studies: Prospective cohort study: A total of 128 recently discharged stroke survivors from five Dublin hospitals were followed for 12 months. During this time 44% of participants fell, 25% repeatedly. Of the fallers, 40% sought healthcare attention after a fall and 10% experienced a fracture. Systematic review of falls prediction models in the year after stroke: Twelve studies were identified that aimed to predict falls in acute or community settings using multivariable models. None presented a validated model with acceptable performance. External validation study of risk prediction models for post-stroke recurrent community falls: Two risk prediction models identified from the review were potentially applicable to the population of interest. These models were applied to the Irish cohort data and were found to have poor discrimination for recurrent falls. There is currently insufficient evidence to rule individuals out as at risk of recurrent falls at discharge Meta-ethnography exploring fall-related experiences of stroke survivors: Six qualitative papers were identified and synthesised. Falls and perceived fall consequences were described in the context of barriers to activity and community participation. The lack of research in the area did not allow for theoretical saturation Qualitative study exploring the experiences of post-stroke recurrent fallers: Nine participants from the cohort study were interviewed 20 months after discharge. Methods of Grounded Theory were employed. The results provided insights into the recovery experiences of recurrent fallers, the importance that they attach to falls and the way in which they self-assess and manage falls-risk. An integration of quantitative and qualitative findings revealed insights around the definition of falls-risk, the timing of falls-risk assessment, patient—professional communication about falls-risk and post-stroke recovery and community reintegration in the context of falls.
Tunnelling geometries I. Analyticity, unitarity and instantons in quantum cosmology
Creators: name: Barvinsky, A. O.
name: Kamenshchik, A. Yu.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a theory of tunnelling geometries originating from the no-boundary quantum state of Hartle and Hawking. We reformulate the no-boundary wavefunction in the representation of true physical variables and calculate it in the one-loop approximation. For this purpose a special technique is developed, which reduces the formalism of complex tunnelling geometries to the real ones, and also the method of collective variables is applied, separating the macroscopic collective degrees of freedom from the microscopic modes. The quantum distribution of Lorentzian universes, defined on the space of such collective variables, incorporates the probabilty conservation and represents the partition function of quasi-DeSitter gravitational instantons weighted by their Euclidean effective action. They represent closed compact manifolds obtained by the procedure of doubling the Euclidean spacetime which nucleates the Lorentzian universes. The over-Planckian behaviour of their distribution is determined by the anomalous scaling of the theory on such instantons, which serves as a criterion for the high-energy normalizability of the no-boudary wavefunction and the validity of the semiclassical expansion.
description: 78 pages, latex, figures are not included (available on request by regular mail), report Alberta Thy-40-93
A red fluorescent BODIPY probe for iridium (III) ion and its application in living cells
Creators: name: Yongjun Bian
name: Xingyu Qu
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry

description: A new red fluorescent probe 1 based on BODIPY skeleton has been successfully synthesized through introduction of 2-(thiophen-2-yl)quinoline motiety at meso- and 3- position, which exhibits excellent optical performance with high fluorescence quantum yield and large pseudo stokes’ shift. The probe 1 shows high selectivity and sensitivity towards iridium (III) ion in aqueous solution and in living cells.
The observational constraint on constant-roll inflation
Creators: name: Gao, Qing
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the constant-roll inflation with constant $ε_2$ and constant $\barη$. By using the method of Bessel function approximation, the analytical expressions for the scalar and tensor power spectra, the scalar and tensor spectral tilts, and the tensor to scalar ratio are derived up to the first order of $ε_1$. The model with constant $ε_2$ is ruled out by the observations at the $3σ$ confidence level, and the model with constant $\barη$ is consistent with the observations at the $1σ$ confidence level. The potential for the model with constant $\barη$ is also obtained from the Hamilton-Jacobi equation. Although the observations constrain the constant-roll inflation to be slow-roll inflation, the $n_s-r$ results from the constant-roll inflation are not the same as those from the slow-roll inflation even when $\barη\sim 0.01$.
description: Typos corrected and references updated. Accepted for publication in Sci. China Phys. Mech. Astron. arXiv admin note: substantial text overlap with arXiv:1801.09208
Gravity wave generation near upper jets, 'striated deltas' and extratropical cyclones
Creators: name: ADAM LEIGH MORGAN
Publisher: name: Monash University
Year: 2019
Subjects: subject: 40102 Atmospheric Dynamics
subject: FOS: Earth and related environmental sciences
subject: Atmospheric Sciences
subject: 40107 Meteorology

description: Curious, triangular-shaped cloud formations called ‘striated deltas’ often accompany deep low pressure systems and feature a pattern of banding visible in satellite imagery. This thesis examines the typical environment in which striated deltas form, and investigates the cause of cloud banding. Gravity waves generated by the upper-level jet stream are likely to determine properties of the banding, and influence characteristics of thunderstorm activity within the cloud. This thesis progresses our understanding of how the jet stream generates gravity waves during low pressure systems, and will improve forecasting of striated deltas and associated severe weather phenomena.
A red fluorescent BODIPY probe for iridium (III) ion and its application in living cells
Creators: name: Xingyu Qu
name: Yongjun Bian
name: Jianqing Li
name: Yufeng Pan
name: Bai, Yang
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry

description: A new red fluorescent probe 1 based on BODIPY skeleton has been successfully synthesized through introduction of 2-(thiophen-2-yl) quinoline moiety at meso- and 3- position, which exhibits excellent optical performance, including high fluorescence quantum yield, large pseudo stokes’ shift as well as high selectivity and sensitivity towards iridium (III) ion in aqueous solution and in living cells.
To characterize standard laboratory coagulation parameters and plasma thrombin generation in very preterm infants and to investigate their relationship to clinical outcomes
Creators: name: Neary, Elaine
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Very premature infants are at risk of bleeding and frequently given plasma because of perception that coagulation tests are abnormal, which may simply be due to immaturity. We hypothesized that characterization of coagulation tests alongside assessment of thrombin generation would provide information on preterm haemostasis. In a prospective observational study, cord and peripheral blood was drawn from neonates <30/40 and on day 1, 3 and fortnightly until 30/40 corrected gestational age (GA). Exclusion criteria included antenatal intraventricular haemorrhage and parental bleeding disorder. Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, procoagulant and anticoagulant factor activity were measured and thrombin generation was characterized. Cord blood of term neonates provided control plasma. Between 2013 - 2015, 137 infants <30/40 were recruited. Median (range) GA and birth weight were 27.9 (23.7-29.9) weeks and 1020 (510-1730) g respectively. Median (5th-95th percentile) Day 1 PT, APTT, and fibrinogen were 17.9 (12.8-27.7) s, 79.1 (48.8-134.3) s and 1.3 (0.7-3.9) g/L respectively (n=127). PT and APTT from preterm cord blood (n=42) were prolonged vs. controls (n=27, p Preterm cord blood peak thrombin and endogenous thrombin potential were similar to controls (132 (40.6) nM vs. 136.7(35) nM; p=0.66 and 1168(289) nM*min vs. 1303 (190) nM*min; p=0.11) respectively (n=27). 20 Mean activity of procoagulant factors II, VII, IX and X (0.31 (0.18-0.5) IU/ml vs. 0.44 (0.35-0.6) IU/ml, p=0.003; 0.33 (0.09-0.57) IU/ml vs. 0.42 (0.31-0.59) IU/ml, p=0.29; 0.16 (0.09-0.5) IU/ml vs. 0.29 (0.19-0.37) IU/ml, p=0.004 and 0.28 (0.13-0.52) IU/ml vs. 0.44 (0.32-0.58) IU/ml, p=0.02) respectively, n=12 and anticoagulant factors Protein C (0.11U/ml (0.06-0.24) IU/ml vs. 0.27 (0.18-0.39) IU/ml; p=0.002), free protein S (0.38 (0.28-0.55) IU/ml vs. 0.47 (0.36-0.59) IU/ml; p=0.02), antithrombin (0.22 (0.06-0.36) IU/ml vs. 0.53 (0.38-0.69) IU/ml; p In conclusion, we describe ranges for coagulation tests, demonstrate differences in both procoagulant and anticoagulant pathways, and show that thrombin generation is similar in very preterm and term infants.
title: Telomere Damage Induces Internal Loops that Generate Telomeric Circles
Creators: name: Mazzucco, Giulia
Publisher: name: The Open University
Year: 2021

description: Telomeres are essential in preventing the recognition of chromosome ends by the double-strand break (DSB) response, thereby permitting the maintenance of linear chromosomes. Extrachromosomal telomeric circles are important players in telomere maintenance, but little is known about their origin. We developed a new procedure for the purification of mammalian telomeric repeats in order to study telomere structures by Electron Microscopy (EM). Using this approach, we detected the expected telomeric features (i.e. t-loops) but we also found accumulation of internal loops (i-loops) at telomeric repeats that occur in the proximity of nicks and single-stranded DNA gaps. We showed that i-loops are induced by single-stranded damage at normal telomeres and represent the majority of the telomeric structures that accumulate in ALT (Alternative Lengthening of Telomeres) tumour cells, which are characterized by DNA damage accumulation at telomeric repeats. We also demonstrated that telomeric molecules containing i-loops can become a source of extrachromosomal telomeric circles. We propose that i-loops can form through strand exchange events at sites of damage, which are facilitated by the high sequence homology at telomeric repeats. This leads to the formation of intramolecular Holliday junctions that can be resolved to generate circular molecules made of telomeric DNA and resulting in a net loss of telomeric repeats. We propose that damage-induced i-loops are common intermediates in telomere maintenance that link telomere damage to the accumulation of extrachromosomal telomeric circles and to telomere erosion.
Hierarchical pinning models, quadratic maps and quenched disorder
Creators: name: Giacomin, Giambattista
name: Lacoin, Hubert
name: Toninelli, Fabio Lucio
Publisher: name: arXiv
Year: 2007
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 60K35, 82B44, 37H10

description: We consider a hierarchical model of polymer pinning in presence of quenched disorder, introduced by B. Derrida, V. Hakim and J. Vannimenius in 1992, which can be re-interpreted as an infinite dimensional dynamical system with random initial condition (the disorder). It is defined through a recurrence relation for the law of a random variable {R_n}_{n=1,2,...}, which in absence of disorder (i.e., when the initial condition is degenerate) reduces to a particular case of the well-known Logistic Map. The large-n limit of the sequence of random variables 2^{-n} log R_n, a non-random quantity which is naturally interpreted as a free energy, plays a central role in our analysis. The model depends on a parameter alpha>0, related to the geometry of the hierarchical lattice, and has a phase transition in the sense that the free energy is positive if the expectation of R_0 is larger than a certain threshold value, and it is zero otherwise. It was conjectured by Derrida et al. (1992) that disorder is relevant (respectively, irrelevant or marginally relevant) if 1/21/2 we find the correct scaling form (for weak disorder) of the critical point shift.
description: 26 pages, 2 figures. v3: Theorem 1.6 improved. To appear on Probab. Theory Rel. Fields
Pharmacoepidemiology and economic evaluation of measures of potentially inappropriate prescribing
Creators: name: Moriarty, Frank
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Uncategorized

description: Background: Several measures of potentially inappropriate prescribing (PIP) exist, however their validity has been under-researched. The aim of this thesis was to assess measures of PIP in older and middle-aged people in primary care in terms of their applicability and relevance in Ireland, effect on patient outcomes and economic impact. Methods: This thesis focussed on community-dwelling adults in Ireland, aged ≥65 years (older adults) or 45-64 years (middle-aged adults). Measures of PIP, the Screening Tool for Older Persons’ Prescriptions (STOPP), the Screening Tool to Alter doctors to Right Treatment (START), and PRescribing Optimally in Middle-aged People’s Treatments (PROMPT) criteria, were applied to two national data sources, the General Medical Services (GMS) scheme dispensing database and The Irish Longitudinal Study on Ageing. Economic analysis was also conducted by developing Markov models of PIP. Results: The prevalence of PIP in older people rose from 1997 to 2012 (32.6%-37.3%), though the odds of having PIP decreased over time after accounting for the increase in medications prescribed. Long-term prescribing of maximal dose proton pump inhibitors grew sharply and was not consistently associated with expected risk factors for gastrointestinal bleeding. PIP was present in 41.6% of middle-aged GMS patients, with prevalent criteria similar to those in older people. For older adults, having ≥2 STOPP criteria was significantly associated with higher rates of emergency department and GP visits, while having ≥2 START omissions was also associated with increased healthcare utilisation, functional decline and reduced quality of life (QoL). In middle-aged people, there was no evidence of a relationship between PROMPT criteria and healthcare utilisation or QoL after controlling for confounders. Of the three PIP criteria evaluated relative to appropriate alternatives in Markov models, long-term benzodiazepine prescribing had the greatest cost and quality-adjusted life year impact, although long-term non-steroidal anti-inflammatory drug use was the most costeffective PIP to target. Conclusion: This thesis demonstrates that PIP is prevalent and can impact on patient and economic outcomes. Optimising prescribing to reduce PIP may provide benefits for patients and the wider health system.
Flowing active liquids in a pipe: Hysteretic response of polar flocks to external fields
Creators: name: Morin, Alexandre
name: Bartolo, Denis
Publisher: name: arXiv
Year: 2018
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We investigate the response of colloidal flocks to external fields. We first show that individual colloidal rollers align with external flows as would a classical spin with magnetic fields. Assembling polar active liquids from colloidal rollers, we experimentally demonstrate their hysteretic response: confined colloidal flocks can proceed against external flows. We theoretically explain this collective robustness, using an active hydrodynamic description, and show how orientational elasticity and confinement protect the direction of collective motion. Finally, we exploit the intrinsic bistability of confined active flows to devise self-sustained microfluidic oscillators.
description: 12 pages, 7 figure; accepted for publication in Physical Review X
On the High $T$ Phase Transition in the Gauged $SU(2)$ Higgs Model
Creators: name: Jain, Vidyut
name: Papadopoulos, Aris
Publisher: name: arXiv
Year: 1992
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the effective field theory of a weakly coupled 3+1d gauged $ϕ^4$ type model at high temperature. Our model has $4N$ real scalars ($N$ complex Higgs doublets) and a gauge group $SU(2)$ which is spontaneously broken by a nonzero scalar field $vev$ at zero temperature. We find, for sufficiently large $N$, that the transition from the high temperature symmetry restoring phase to the low temperature phase can be either first order or second order depending on the ratio of the gauge coupling to the scalar self coupling.
description: 16 pages. 1 Figure, not included
A red fluorescent BODIPY probe for iridium (III) ion and its application in living cells
Creators: name: Xingyu Qu
name: Yongjun Bian
name: Jianqing Li
name: Yufeng Pan
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry

description: A new red fluorescent probe 1 based on BODIPY skeleton has been successfully synthesized through introduction of 2-(thiophen-2-yl) quinoline moiety at meso- and 3- position, which exhibits excellent optical performance, including high fluorescence quantum yield, large pseudo stokes’ shift as well as high selectivity and sensitivity towards iridium (III) ion in aqueous solution and in living cells.
Grey-box state-space identification of nonlinear mechanical vibrations
Creators: name: Noël, Jean-Philippe
name: Schoukens, Johan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The present paper deals with the identification of nonlinear mechanical vibrations. A grey-box, or semi-physical, nonlinear state-space representation is introduced, expressing the nonlinear basis functions using a limited number of measured output variables. This representation assumes that the observed nonlinearities are localised in physical space, which is a generic case in mechanics. A two-step identification procedure is derived for the grey-box model parameters, integrating nonlinear subspace initialisation and weighted least-squares optimisation. The complete procedure is applied to an electrical circuit mimicking the behaviour of a single-input, single-output (SISO) nonlinear mechanical system and to a single-input, multiple-output (SIMO) geometrically nonlinear beam structure.
On the Abundance of Primordial Helium
Creators: name: Olive, Keith A.
name: Steigman, Gary
Publisher: name: arXiv
Year: 1994
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have used recent observations of helium-4, nitrogen and oxygen from some four dozen, low metallicity, extra-galactic HII regions to define mean $N$ versus $O$, $^4He$ versus $N$ and $^4He$ versus $O$ relations which are extrapolated to zero metallicity to determine the primordial $^4He$ mass fraction $Y_P$. The data and various subsets of the data, selected on the basis of nitrogen and oxygen, are all consistent with $Y_P = 0.232 \pm 0.003$. For the 2$σ$ (statistical) upper bound we find $Y_P^{2σ} \le 0.238$. Estimating a 2\% systematic uncertainty $(σ_{syst} = \pm 0.005)$ leads to a maximum upper bound to the primordial helium mass fraction: $Y_P^{MAX} = Y_P^{2σ} + σ_{syst} \le 0.243$. We compare these upper bounds to $Y_P$ with recent calculations of the predicted yield from big bang nucleosynthesis to derive upper bounds to the nucleon-to-photon ratio $η$ ($η_{10} \equiv 10^{10}η$) and the number of equivalent light (\lsim 10 MeV) neutrino species. For $Y_P \le 0.238$ ($0.243$), we find $η_{10} \le 2.5 (3.9)$ and $N_ν\leq 2.7 (3.1)$. If indeed $Y_P \le 0.238$, then BBN predicts enhanced production of deuterium and helium-3 which may be in conflict with the primordial abundances inferred from model dependent (chemical evolution) extrapolations of solar system and interstellar observations. Better chemical evolution models and more data - especially $D$-absorption in the QSO Ly-$α$ clouds - will be crucial to resolve this potential crisis for BBN. The larger upper bound, $Y_P \leq 0.243$ is completely
description: 21 pages, LaTeX, 6 postscript figures available upon request, UMN-TH-1230
Additional file 1 of The incubation period of COVID-19: a global meta-analysis of 53 studies and a Chinese observation study of 11 545 patients
Creators: name: Cheng, Cheng
name: Zhang, DongDong
name: Dang, Dejian
name: Geng, Juan
name: Zhu, Peiyu
name: Yuan, Mingzhu
name: Liang, Ruonan
name: Yang, Haiyan
name: Jin, Yuefei
name: Xie, Jing
name: Chen, Shuaiyin
name: Duan, Guangcai
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Astronomical and Space Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Cardiology

description: Additional file 1. Additional Table S1.
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0136
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0136, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0136, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Tunnelling geometries II. Reduction methods for functional determinants
Creators: name: Barvinsky, A. O.
Publisher: name: arXiv
Year: 1993
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The reduction algorithms for functional determinants of differential operators on spacetime manifolds of different topological types are presented, which were recently used for the calculation of the no-boundary wavefunction and the partition function of tunnelling geometries in quantum gravity and cosmology.
description: 23 pages, latex, figures are not included (available on request by regular mail), report Alberta Thy-41-93
Enhancing Wind Turbine Location Accuracy: a Deep Learning-Based Object Regression Approach for Validating Wind Turbine Geo-Coordinates
Creators: name: Kleebauer, Maximilian
name: Braun, Axel
name: Horst, Daniel
name: Pape, Carsten
Publisher: name: Universität Kassel
Year: 2024
Subjects: subject: wind turbines
subject: renewable energy systems
subject: object regression
subject: geo-coordinate validation
subject: 600
subject: Windturbine
subject: Erneuerbare Energien
subject: Geoinformation
subject: Deep learning
subject: Fernerkundung

description: Autorenversion; © 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
title: ADCO, Cartulaire de Fontenay, second fragment (XIIIe siècle), Cart. 201 (15 H 9), folios 47-142, f. 011r
Creators: name: de la Côte d'Or, Archives départementales
name: CG21/F.PETOT/2009
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Fontenay, second fragment (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 201 (15 H 9), folios 47-142. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Fontenay, second fragment (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 201 (15 H 9), folios 47-142, f. 011r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb119679755
description: Provenance: https://www.geonames.org/7874015
description: Provenance: http://www.idref.fr/027691802/id
description: Provenance: abbaye de Fontenay
description: Provenance: http://www.wikidata.org/entity/Q464918
Dynamic Bounds on Stochastic Chemical Kinetic Systems Using Semidefinite Programming
Creators: name: Dowdy, Garrett R.
name: Barton, Paul I.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Probability (math.PR)
subject: Optimization and Control (math.OC)
subject: Molecular Networks (q-bio.MN)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Mathematics
subject: FOS: Biological sciences

description: Applying the method of moments to the chemical master equation (CME) appearing in stochastic chemical kinetics often leads to the so-called closure problem. Recently, several authors showed that this problem can be partially overcome using moment-based semidefinite programs (SDPs). In particular, they showed that moment-based SDPs can be used to calculate rigorous bounds on various descriptions of the stochastic chemical kinetic system's stationary distribution(s) -- for example, mean molecular counts, variances in these counts, and so on. In this paper, we show that these ideas can be extended to the corresponding dynamic problem, calculating time-varying bounds on the same descriptions.
Nimbandiolactone-21 and nimbandioloxyfuran, two new 28-norlimonoids from the leaves of Azadirachta indica (Meliaceae)
Creators: name: Nguyen, Nhi Y Thi
name: Dang, Phu Hoang
name: Nguyen, Van Truong Thien
name: Vo, Tuan Trong
name: Nguyen, Dao Anh Thi
name: Nguyen, Minh Duc Huu
name: Dang, Phuc Huu
name: Tran, Quan Le
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: From an EtOAc-soluble fraction of the leaves of Azadirachta indica, two new 28-norlimonoids named nimbandiolactone-21 (1) and nimbandioloxyfuran (2), together with nimbandiolactone-23 (3), were isolated. Their relative structures were elucidated based on NMR spectroscopic interpretation and biosynthetic consideration. Nimbandioloxyfuran (2) and nimbandiolactone-23 (3) showed potent α-glucosidase inhibitory activity, with the IC50 values of 46.2 and 38.7 μM, respectively.
Additional file 2 of Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis
Creators: name: Xie, Zhengjun
name: Peng, Wei
name: Li, Qiuhua
name: Cheng, Wei
name: Zhao, Xin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Hematology

description: Additional file 2: Table S2. PRISMA 2009 Flow Diagram.
Wave-particle duality in multi-path interferometers: General concepts and three-path interferometers
Creators: name: Englert, Berthold-Georg
name: Kaszlikowski, Dagomir
name: Kwek, Leong Chuan
name: Chee, Wei Hui
Publisher: name: arXiv
Year: 2007
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: For two-path interferometers, the which-path predictability $\mathcal{P}$ and the fringe visibility $\mathcal{V}$ are familiar quantities that are much used to talk about wave-particle duality in a quantitative way. We discuss several candidates that suggest themselves as generalizations $P$ of $ mathcal{P}$ for multi-path interferometers, and treat the case of three paths in considerable detail. To each choice for the \emph{path knowledge} $P$, the \emph{interference strength} $V$ -- the corresponding generalization of $\mathcal{V}$ -- is found by a natural, operational procedure. In experimental terms it amounts to finding those equal-weight superpositions of the path amplitudes which maximize $P$ for the emerging intensities. Mathematically speaking, one needs to identify a certain optimal one among the Fourier transforms of the state of the interfering quantum object. Wave-particle duality is manifest, inasmuch as P=1 implies V=0 and V=1 implies P=0, whatever definition is chosen. The possible values of the pair $(P,V)$ are restricted to an area with corners at $(P,V)=(0,0)$, $(P,V)=(1,0)$, and $(P,V)=(0,1)$, with the shape of the border line from $(1,0)$ to $(0,1)$ depending on the particular choice for $P$ and the induced definition of $V$.
description: 28 pages, 6 figures
High-energy environment of super-Earth 55 Cnc e I: Far-UV chromospheric variability as a possible tracer of planet-induced coronal rain
Creators: name: Bourrier, V.
name: Ehrenreich, D.
name: Etangs, A. Lecavelier des
name: Louden, T.
name: Wheatley, P. J.
name: Wyttenbach, A.
name: Vidal-Madjar, A.
name: Lavie, B.
name: Pepe, F.
name: Udry, S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The irradiation of close-in planets by their star influences their evolution and might be responsible for a population of ultra-short period planets eroded to their bare core. In orbit around a bright, nearby G-type star, the super-Earth 55 Cnc e offers the possibility to address these issues through UV transit observations. We used the Hubble Space Telescope to observe the transit in the FUV over 3 epochs in Apr. 2016, Jan. 2017, and Feb. 2017. These observations reveal significant short- and long-term variability in 55 Cnc chromospheric emission lines. In the last 2 epochs, we detected a larger flux in the C III, Si III, and Si IV lines after the planet passed the approaching quadrature, followed by a flux decrease in the Si IV doublet. In the second epoch these variations are contemporaneous with flux decreases in the Si II and C II doublet. All epochs show flux decreases in the N V doublet as well, albeit at different orbital phases. These flux decreases are consistent with absorption from optically thin clouds of gas, are mostly localized at low and redshifted radial velocities in the star rest frame, and occur preferentially before and during the transit. These 3 points make it unlikely that the variations are purely stellar, yet we show that the occulting material is also unlikely to originate from the planet. We tentatively propose that the motion of 55 Cnc e at the fringes of the stellar corona leads to the formation of a cool coronal rain. The inhomogeneity and temporal evolution of the stellar corona would be responsible for the differences between the visits. Additional variations are detected in the C II doublet in the first epoch and in the O I triplet in all epochs with a different behavior that points toward intrinsic stellar variability. Further observations at FUV wavelengths are required to disentangle between star-planet interactions and the activity of the star
description: 22 pages, 20 figures, accepted for publication in A&A
A Classification of Hidden-Variable Properties
Creators: name: Brandenburger, Adam
name: Yanofsky, Noson
Publisher: name: arXiv
Year: 2007
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Hidden variables are extra components added to try to banish counterintuitive features of quantum mechanics. We start with a quantum-mechanical model and describe various properties that can be asked of a hidden-variable model. We present six such properties and a Venn diagram of how they are related. With two existence theorems and three no-go theorems (EPR, Bell, and Kochen-Specker), we show which properties of empirically equivalent hidden-variable models are possible and which are not. Formally, our treatment relies only on classical probability models, and physical phenomena are used only to motivate which models to choose.
description: 28 pages; added references; clearer exposition. Final version
Unmotherly Love: the Medea Model in Mary Sidney's Antonius
Creators: name: Zanoni, Roberta
Publisher: name: Skenè. Journal of Theatre and Drama Studies
Year: 2021

description: Mary Sidney’s Antonius, the English translation of Robert Garnier’s Marc Antoine, offers the first example of a closet drama in early modern English that not only used classical resources but was also written by a woman. It is worth exploring the possibility that Euripides’s and Seneca’s versions have coloured Sidney’s reception and re-elaboration of Garnier’s play. Although neither has yet been connected with Garnier’s and Sidney’s plays, Sidney’s version effectively shows significant similarities in her construction of the female protagonist with particular reference to the dramatisation of unmotherly love. Through an in-depth investigation of these parallels, I will attempt to illustrate Mary Sidney’s approach to the Medea model and her own intervention, which include the influence of Studley’s translation of Seneca’s Medea; I will also explore how this intertextuality leads to the construction of Cleopatra as a stronger female ruler who abandons her children for her lover Antonius, and for her resolution to die after he has died. This article highlights how reading these aspects of Mary Sidney’s play in the early modern context may involve the identification of parallels with the situation in England linked to the Elizabethan succession. Keywords: Mary Sidney; Antonius; Robert Garnier; Euripides; Seneca; Studley; translation; Elizabethan succession
description: Skenè. Journal of Theatre and Drama Studies, Vol. 7 No. 1 (2021): Virtual Theatre