cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Galectin-1-based tumour-targeting for gold nanostructure-mediated photothermal therapy
Creators: name: Jenkins, Samir V.
name: Nedosekin, Dmitry A.
name: Miller, Emily K.
name: Zharov, Vladimir P.
name: Dings, Ruud P. M.
name: Jingyi Chen
name: Griffin, Robert J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Purpose: To demonstrate delivery of Au nanocages to cells using the galectin-1 binding peptide anginex (Ax) and to demonstrate the value of this targeting for selective in vitro photothermal cell killing. Materials and methods: Au nanocages were synthesised, coated with polydopamine (PDA), and conjugated with Ax. Tumour and endothelial cell viability was measured with and without laser irradiation. Photoacoustic (PA) mapping and PA flow cytometry were used to confirm cell targeting in vitro and in tissue slices ex vivo. Results: Cell viability was maintained at ≥50% at 100 pM suggesting low toxicity of the nanocage alone. Combining the targeted construct (25 pM) with low power 808 nm laser irradiation for 10–20 min (a duration previously shown to induce rapid and sustained heating of Au nanocages [AuNC] in solution), resulted in over 50% killing of endothelial and tumour cells. In contrast, the untargeted construct combined with laser irradiation resulted in negligible cell killing. We estimate approximately 6 × 104 peptides were conjugated to each nanocage, which also resulted in inhibition of cell migration. Binding of the targeted nanocage reached a plateau after three hours, and cell association was 20-fold higher than non-targeted nanocages both in vitro and ex vivo on tumour tissue slices. A threefold increase in tumour accumulation was observed in preliminary in vivo studies. Conclusions: These studies demonstrate Ax’s potential as an effective targeting agent for Au-based theranostics to tumour and endothelial cells, enabling photothermal killing. This platform further suggests potential for multimodal in vivo therapy via next-generation drug-loaded nanocages.
Self-growth of micro- and nano-structured Mg(OH)2 on electrochemically anodised Mg–Li alloy surface
Creators: name: Wang, Limei
name: Wang, Guiling
name: Wu, Tianhao
name: Cao, Dianxue
name: Yin, Jinling
name: Zhang, Milin
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Physics
subject: Engineering
subject: Biochemistry

description: Formation of Mg(OH)2 nanowires and their assemblies with sphere-shaped, echinus-shaped and nest-like micro-structures on a Mg-Li alloy surface was successfully demonstrated. Mg(OH)2 nanowires were formed on the alloy surface via a self-growth process, after the alloy was electrooxidised in NaCl solution and the oxidation products were removed. The nanowires were characterised by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Infrared spectroscopy. The nanowires have hexagonal rod-like or brush-like morphology and are poorly crystallised. Pre-anodisation and the presence of Li in the alloy are key factors for the nanowire growth, which likely proceeds via a dissolution–precipitation mechanism. The roles of Li can be attributed to the prohibition of the formation of passivation film on the alloy surface and the acceleration of the formation of OH− anions through hydrogen-evolution reaction.
Two new xanthones from the pericarp of Garcinia mangostana
Creators: name: Zhou, Xiaojun
name: He, Luan
name: Wu, Xinxing
name: Zhong, Yanxia
name: Zhang, Juan
name: Wang, Yuanxing
name: Wang, Bin
name: Xu, Zhifang
name: Qiu, Shengxiang
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Biochemistry

description: Two new xanthones, designated garcimangosxanthone F (1) and garcimangosxanthone G (2), were isolated from the EtOAc-soluble fraction of ethanolic extract from the pericarp of Garcinia mangostana. Their structures were established as 1,6,7-trihydroxy-5-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbutyl)-6′,6′-dimethylpyrano[2′,3′:3,2]xanthone and 1,6,7-trihydroxy-5-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbutyl)-6′,6′-dimethyl-4′,5′-dihydropyrano[2′,3′:3,2]xanthone, respectively, on the basis of their 1D, 2D NMR and MS data interpretation.
Proteomic profiling during the pre-competent to competent transition of the biofouling polychaete Hydroides elegans
Creators: name: Zhang, Yu
name: Sun, Jin
name: Zhang, Huoming
name: H. Chandramouli, Kondethimmanahalli
name: Xu, Ying
name: He, Li-Sheng
name: Ravasi, Timothy
name: Qian, Pei-Yuan
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: The polychaete, Hydroides elegans, is a tube-building worm that is widely distributed in tropical and subtropical seas. It is a dominant fouling species and thus a major target organism in antifouling research. Here, the first high-throughput proteomic profiling of pre-competent and competent larvae of H. elegans is reported with the identification of 1,519 and 1,322 proteins, respectively. These proteins were associated with a variety of biological processes. However, a large proportion was involved in energy metabolism, redox homeostasis, and microtubule-based processes. A comparative analysis revealed 21 proteins that were differentially regulated in larvae approaching competency.
MOESM1 of Engineering the oleaginous yeast Yarrowia lipolytica to produce limonene from waste cooking oil
Creators: name: Pang, Yaru
name: Zhao, Yakun
name: Li, Shenglong
name: Zhao, Yu
name: Li, Jian
name: Hu, Zhihui
name: Zhang, Cuiying
name: Xiao, Dongguang
name: Yu, Aiqun
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. Information on fatty acid composition of the commercial vegetable oil and waste cooking oil. Table S2. Primers used in PCR. Figure S1. Inhibitory effects of d‑limonene and l-limonene on S. cerevisiae AY15 and Y. lipolytica Po1g KU70Δ. Figure S2. GC–MS analysis of solvent overlay-extracted limonene from engineered strains cultures. Figure S3. Effect of different carbon sources on growth of Y. lipolytica. Figure S4. Effect of addition of glucose on biosynthesis of limonene. Figure S5. The OD600 values of different engineered Y. lipolytica strains cultured in YPD medium. Figure S6. Effect of temperature on volatilization of limonene. Figure S7. The pHs during fermentation of the engineered Y. lipolytica Po1g KdHR and Po1g KlHR strains in a 250-mL shake flask. Figure S8. The data of limonene batch-fermentation parameters in the 5 L-fermenter. Figure S9. Effect of Mg2+ on growth of Y. lipolytica. Figure S10. Effect of Mn2+ on d-limonene or l-limonene accumulation in Po1g KdHR or Po1g KlHR. Figure S11. Effect of concentration of peptone on the production of d-limonene and l-limonene. Figure S12. The data of limonene fed-batch fermentation parameters in the 5-L fermenter. Figure S13. Map of the plasmid pYLEX1. Figure S14. Map of the recombinant plasmid pYLdLS. Figure S15. Maps of the overexpression recombinant plasmid pYLA1 and pYLdA1. Figure S16. The GC–MS analysis of fatty acid composition in waste cooking oil and commercial vegetable oil.
supplimentry material for manuscript RSOS-170006.R1
Creators: name: Mayank Sharma
name: Hitendra Patel
Publisher: name: figshare
Year: 2017
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: 30504 Organic Green Chemistry
subject: NMR Spectroscopy

description: supplementary ml ad other supporting data for manuscript RSOS-170006.R1 entitled Green approach for synthesis of bioactive Hantzsch 1, 4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction
A Eucaristia e a missão da Igreja: uma reflexão sobre a Sacramentum caritatis de Bento XVI
Creators: name: Cunha, Jorge Teixeira Da
Publisher: name: Didaskalia
Year: 2008

description: A proposta que estrutura este comentário à exortação “Sacramentum caritatis” é elaborada na base do pensamento de Michel Henry e de Emmanuel Levinas. Cremos que há, no texto pós-sinodal, abertura para compreender a Eucaristia a partir do Outro, caminho que, a nosso ver, se revela muito mais fecundo do que outros para entrar no mistério. A chave encontra-se no interior do edifício, como nota François-Xavier Durrwell. O “mais” que é o mistério pascal de Jesus é que explica o “menos” que é o gesto sacramental da Eucaristia. Esperamos mostrar como esta mudança de perspectiva se revela muito interessante para chamar a atenção para a centralidade da Eucaristia na vida da Igreja.
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
A visão beatífica e a noção de mistério em K. Rahner
Creators: name: Farias, José Jacinto Ferreira De
Publisher: name: Didaskalia
Year: 2008

description: O estudo visa uma breve apresentação do contributo de K. Rahner para uma renovada compreensão da noção teológica de mistério, categoria fundamental no cristianismo e na teologia, que é, de certo modo, a ciência do mistério. O núcleo fundamental do seu contributo - que se inspira, por um lado em S. Tomás de Aquino, e, por outro, numa certa corrente filosófica contemporânea, que tem em G. Marcel um dos seus mais significativos representantes - consiste em operar uma inversão metodológica, ou seja, em vez de considerar o mistério a partir dos limites da razão, fazê-lo a partir da visão beatífica e do tema do lumen gloriae. O mistério vai surgir então referido directamente a Deus, e não tanto a proposições que ultrapassam os limites da razão. A pluralidade dos mistérios resume-se quase apenas a três: a Santíssima Trindade, a Incarnação e a união hipostática, e a elevação das criaturas à comunhão com Deus na graça. Tudo o resto será como que um desdobramento destes três mistérios fundamentais. A conclusão de K. Rahner será de natureza antropológica, mostrando que o homem é essencialmente o ser do mistério, da infinita transcendência espiritual, aberto e disponível ao excesso de sentido que o mistério, como grandeza solar, em si mesmo encerra.
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
Education: optimal choice and efficient policy
Creators: name: Richter, Wolfram F.
name: Schneider, Kerstin
Publisher: name: TU Dortmund
Year: 2021
Subjects: subject: 330

description: This paper argues that it suffices to assume distortionary wage taxation to prove the efficiency of effective subsidization of education. The paper does not rely on considerations of equity and market failure to justify subsidies. Instead, the optimal subsidy reduces the social cost of distortive wage taxation. The theoretical approach assumes a Mincer-type earnings function, analyzes corner solutions of optimal schooling choice and derives the result of efficient subsidization in a Ramsey-type framework. Second-best policy is confronted with empirical evidence from OECD countries. The majority of countries are shown to subsidize tertiary education in effective terms.
description: Can. J. Econ.;54(2)
Em torno de A desilusão de Deus, de Richard Dawkins
Creators: name: Coutinho, Jorge
Publisher: name: Didaskalia
Year: 2008

description: Richard Dawkins, conhecido biólogo britânico, publicou, em 2006, The God Delusion, com a presumida intenção de provar, com base na ciência, que (é quase certo que) Deus não existe. Tecem-se aqui algumas considerações. No essencial: o livro, além de nada provar do que pretende, desqualifica o autor, seja pela atitude moral, seja pela errância epistemológica em que labora. O grave do caso é que este livro é um sinal de uma renovada militância ateísta e da presença exacerbada, no mundo da cultura, de um autêntico fundamentalismo cientista, ao serviço de uma cultura sem Deus.
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
Additional file 1 of The impact of long-term aspirin use on the patients undergoing shoulder arthroplasty
Creators: name: Mao, Xiuhua
name: Liang, Chen
name: Li, Xiaoqin
name: Shi, Danping
name: Yang, Qinfeng
name: Xie, Hao
name: Liang, Fangguo
name: Cui, Yuhui
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. ICD-9 codes and ICD-10 codes for perioperative complications.
Molecular recognition of amphiphilic p-sulfonatocalix[4]arene with organic ammoniums
Creators: name: Ding, Fei
name: Liu, Yu
name: Hu, Xin-Yue
name: Peng, Shu
name: Guo, Dong-Sheng
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Cancer
Biological Sciences
Chemistry
Biochemistry
Biophysics

description: The binding abilities and thermodynamic origin for the intermolecular complexation of two water-soluble calixarenes, p-sulfonatocalix[4]arene (SC4A) and 5,11,17,23-tetrasulfonato-25,26,27,28-tetrakis(n-butyl)-calix[4]arene (SC4A-Bu), with six organic cations: 1,4-diazabicyclo[2,2,2]octane (G1), 3,5,6,8,-tetrahydropyrazino[1,2,3,4-Imn][1,10]phenanthroline (G2), diquat (G3), paraquat (G4), 1-methylpyridin-1-ium (G5) and 1,3-dimethylimidazolium (G6), have been determined by means of isothermal titration calorimetry in aqueous solutions at pH 7.0, 298.15 K, and their binding modes have been investigated by NMR spectroscopy. The obtained results indicate that the binding modes of SC4A-Bu and SC4A change a little but their binding affinities show great difference, resulting from the distinguishable binding thermodynamics. The binding selectivity of G1 is up to 688 times for the SC4A/SC4A-Bu hosts, and SC4A-Bu prefers to include planer molecules of large π system with low electron density. The aggregation behaviours of SC4A-Bu before and after complexation with G3 were then investigated, showing that G3 is able to induce the aggregation of SC4A-Bu.
A exterioridade de Deus: uma aproximação à teoria da religião de Régis Debray
Creators: name: Teixeira, Alfredo
Publisher: name: Didaskalia
Year: 2008

description: Este ensaio insere-se num plano mais vasto de pesquisa sobre as «novas teorias da religião». Aqui, procura identificar-se o contexto e a especificidade da interrogação mediológica perante o facto religioso, testando os seus instrumentos de indagação num dos universos de pesquisa privilegiados por Régis Debray: as representações do «Deus Único» e as Escrituras como medium da sua historicização. Depois deste primeiro itinerário, a mediologia de R. Debray é confrontada com os problemas hermenêuticos que decorrem da operação de redução do «sentido» à «função».
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
O amor a Deus num filósofo “ateu”
Creators: name: Ferreira, Maria Luísa Ribeiro
Publisher: name: Didaskalia
Year: 2008

description: Partindo de um mesmo desejo de alcançar Deus analisam-se alguns traços do pensamento de St. Agostinho e de Espinosa, filósofos que divergem profundamente nos seus interesses, nos temas abordados, nos objectivos que se propõem ao fazer filosofia. Aproximam-se, no entanto, na valorização da inquietude que habita cada homem – o coração inquieto de Agostinho e o “conatus” espinosano. O pensamento antropológico de cada um dos filósofos tem como consequência uma dada concepção de divindade. Confrontadas as divergências entre o Deus pessoal de Agostinho e o Deus/Natureza de Espinosa, levantam-se alguns problemas quanto à religiosidade deste último, bem como à pertinência da sua designação como filósofo ateu.
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
Additional file 1 of Clinical and molecular characteristics of methicillin-resistant Staphylococcus aureus in bone and joint infection among children
Creators: name: Fu, Pan
name: Nijiati, Yaxier
name: Li, Tingting
name: Wu, Xia
name: Wang, Zixuan
name: Zhou, Jinlan
name: Wang, Chuanqing
name: Ning, Bo
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1: Table S1. Antimicrobial resistance ratios of different MRSA genotypes (%).
Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC–ESI-QTOF-MS
Creators: name: Yang, Yi
name: Akber Aisa, Haji
name: Gu, Dongyu
name: Hang, Ba
name: Lv, Qiaoying
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Microbiology
subject: FOS: Biological sciences
subject: Engineering
subject: Biochemistry

description: An efficient method was developed and established for the rapid analysis of a traditional Uighur medicinal prescription, Yizhihao granule, by liquid chromatography-Quadrupole time-of-flight tandem mass spectrometry. HPLC was performed with a Poroshell 120-EC18 column with 2.7 µm particle size using A gradient elution system. A quadrupole time-of-flight analyzer was used for the determination of accurate mass of the protonated or deprotonated molecules and fragment ions. Sixty-six constituents including amino acids, organic acids (aliphatic acids, benzoic acid derivatives, and chlorogenic acids), alkaloids (indole and quinazolinone type), flavonoids (C,O-glycoside, C-glycosides, O-glycosides, and aglycone), sesquiterpenoids (rupestonic acid derivatives), and other compounds were identified or tentatively characterized in Yizhihao granule as a presented application of prescription according to the accurate mass, MS/MS data, and relevant literature. Additionally, the fragmentation pathways of two rupestonic acid derivatives were proposed. The relationship between structure features and fragmentation patterns were investigated thoroughly and applied in the on-line analysis to deduce the composition of traditional Uighur herbal prescription. The present method and results should be beneficial in the development of traditional Uighur herbal prescription.
Animismo, teocracia, democracia: o processo de “desencantamento do mundo” como referencial ambíguo da modernidade
Creators: name: Varanda, Isabel
Publisher: name: Didaskalia
Year: 2008

description: Escolhemos quatro pensadores para nos guiarem neste estudo: Jacques Monod, Max Weber, Marcel Gauchet e Peter Berger. Através deles e das intersecções das respectivas ideias, entramos num cenário denso, confuso, multiconceptual e ambíguo, que se apresenta, desde já, resistente a qualquer tentativa de rigor descritivo e de leitura unívoca. À partida, vemos um carreiro tosco, de traçado inseguro e incerto, pelo qual vamos tentar entrar no movimento das ideias e das representações do mundo, com o objectivo de descrever um ponto de vista deste movimento: “o desencantamento do mundo” como referencial da modernidade. A audácia é grande, mas não arrogante. Vamos tentar entrar na conjunção de múltiplos conceitos, na esperança de chegar a um ponto de intersecção que nos dê acesso a uma visão renovada. O caldo conceptual – animismo, desencantamento do mundo, teocracia, secularização, democracia, modernidade, dessecularização – faz aparecer a dinâmica da miscigenação dos elementos em incessantes combinações e recomposições; não se trata do algoritmo de uma experiência de laboratório; trata-se da história da nossa vida e da história das ideias que nos fazem viver. Ideias e ideais que, tacteantes, forjam uma nova terra e um novo céu à imagem dos Modernos, onde continua a ser possível viver e acreditar.
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
A stochastic inventory model with price quotation
Creators: name: Kim, Kyoung-Kuk
name: Liu, Jun
name: Lee, Chi-Guhn
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology

description: This article studies a single-item periodic-review inventory problem with stochastic demand, uncertain price, and price search cost. At the beginning of a period, an inventory manager has to decide, considering the current inventory level, whether a price should be searched for at a non-zero cost. Once the price is known, she will have to decide the order size. For tractability the number of realizable prices is limited to two and (r, S1, S2)-type policies are considered, where r is the threshold for the price search decision and Si is the order-up-to level for price pi for i = 1, 2. Although the problem is significantly simplified, it still allows for price speculations by the inventory manager; i.e., she requests a quote but may not buy. The properties of long-run average costs are studies and optimization algorithms are presented. Numerical studies show the effectiveness of the proposed policy compared with classic (s, S)-type policy and its natural three-parameter extension.
A Stochastic Inventory Model with Price Quotation
Creators: name: Kim, Kyoung-Kuk
name: Liu, Jun
name: Lee, Chi-Guhn
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology

description: We study a single item periodic review inventory problem with stochastic demand, uncertain price and price search cost. At the beginning of a period, an inventory manager has to decide, considering the current inventory level, whether a price should be searched for at a non-zero cost. Once the price is known, she will have to decide the order size. For tractability we limit the number of realizable prices to two and consider (r, S1, S2)-type policies, where r is the threshold for the price search decision and Si is the order-up-to level for price pi for i = 1, 2. While the problem is significantly simplified, it still allows the inventory manager for price speculations, i.e., she requests a quote but may not buy. We study properties of long-run average costs and devise optimization algorithms. Numerical studies show the effectiveness of the proposed policy compared with classical (s, S)-type policy and its natural 3-parameter extension.
Cristianismo e cultura
Creators: name: Nunes, José
Publisher: name: Didaskalia
Year: 2008

description: A relação entre cristianismo e cultura é parte integrante da mais vasta problemática entre religiões e cultura(s). Numa época de aparição de variados fundamentalismos religiosos, num momento em que a Europa se questiona sobre as suas raízes cristãs, a actualidade do tema parece evidente. Neste artigo, procura-se primeiramente uma verificação das modalidades de relação entre cristianismo e cultura ao longo da história; em seguida, enunciam-se algumas condições para uma positiva relação entre tais realidades; finalmente, constata-se a presença do cristianismo na cultura, particularmente num ocidente que já conheceu um profundo processo de secularização e racionalidade.
description: Didaskalia, v. 38 n. 2 (2008): O conhecimento de Deus: homenagem a Henrique de Noronha Galvão
Effectiveness of Social Host and Fake Identification Laws on Reducing Underage Drinking Driver Fatal Crashes
Creators: name: C. Fell, James
name: Scherer, Michael
name: Thomas, Sue
name: B. Voas, Robert
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Medicine
subject: Engineering

description: Objective: The public generally assumes that the minimum legal drinking age of 21 (MLDA-21) legislation in the United States is embodied in a single law and therefore all states have the same law. Actually, the MLDA-21 state laws consist of multiple provisions that support the core MLDA-21 laws and include a family of policies directed at controlling underage drinking and underage drinking and driving. Because social host and fake identification laws have recently garnered interest by policy makers in the states, this study was designed to determine their effectiveness.Methods: The effective dates for 2 types of social host laws and 3 fake identification laws were documented using the Alcohol Policy Information System (APIS), the Substance Abuse and Mental Health Services Administration's (SAMHSA) 2011 Report to Congress on the Prevention and Reduction of Underage Drinking, and legal research tools. These laws include social host prohibitions (SHPs) and social host civil liability (SHCL), the use of fake identification (FID), retailer support for FID, and transfer/production of FID. We used a pre–post design to evaluate the influence on underage drinking-and-driving fatal crashes of these 5 laws using the Fatality Analysis Reporting System (FARS) data set for the years 1982 through 2010. The data were analyzed using structural equation modeling (SEM) controlling for as many variables as possible.Results: For those drivers younger than aged 21 years, FID supplier laws were associated with significant decreases in FARS ratios after states adopted these laws (−1.0%, P =.030).Conclusions: The 24 states that have adopted FID supplier laws are saving an estimated 14 lives per year in the United States. An additional 16 lives could be saved if the remaining states adopted this law. FID supplier laws prohibit the production of a FID or transfer of an ID or FID to another person. The more stringent the law (i.e., whether a state prohibits only one element [weaker law] compared to both transferring and manufacturing a FID [stronger]) the more effective a deterrent it becomes to supplying a minor with a FID. States without FID supplier laws should consider adopting them.
Taciturnidade e silêncio: para a história do silêncio monástico
Creators: name: Matoso, José
Publisher: name: Didaskalia
Year: 2009

description: O silêncio simultaneamente contemplativo e afectivo cultivado em meios monásticos ocidentais parece nascer entre os cluniacenses (concretamente com o abade Odo, 927-942), e seguir uma tradição que se transmite através de Guilherme de St-Thierry e de Aelredo de Rievaulx (ambos ligados à espiritualidade cisterciense), da segunda ou terceira geração dos cartuxos, e finalmente de Mestre Eckhart e do seu discípulo João Tauler. Nas origens do monaquismo oriental e ocidental considerava-se sobretudo a sua forma ascética. A tradição mística derivada da teologia apofática inspirada nos escritos de Dionísio Areopagita suscitou uma grande quantidade de obras místicas, sobretudo nos autores de S. Victor de Paris e seus sucessores, mas era considerada demasiado especulativa pelos autores monásticos mais acessíveis como o que redigiu The Cloud of Unknowing e o próprio Tauler.
description: Didaskalia, v. 39 n. 1 (2009): Cartografias do silêncio
Two new entangled complexes based on 4,4′-bis(1-imidazolyl)biphenyl: syntheses, structures, thermal and photoluminescent properties
Creators: name: Wang, Yue
name: Qi, Yan
name: Li, Qun
name: Lu, Zhou
name: Wang, Yanwei
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Physics
Engineering
Biochemistry
Biophysics

description: Two new entangled complexes, [Zn(bibp)(L1)]·0.25H2O (1) and [Co(bibp)(H2L2)] (2) (bibp = 4,4′-bis(1-imidazolyl)biphenyl, H2L1 = 4,4′-(2,2′-oxybis(ethane-2,1-diyl)bis(oxy))dibenzoic acid, and H4L2 = 5,5′-(2,2′-oxybis(ethane-2,1-diyl)bis(oxy))diisophthalic acid), have been synthesized hydrothermally. Complex 1 features a new uninodal four-connected (65·8) net with vertex symbol 6·6·6·6·62·82, which is different from all that exhibit uninodal four-connected (65·8) nets found in the literature, including cds, dmp, ict, mok, unl and unm. Three of these nets interpenetrate. Complex 2 shows an unusual threefold 2-D → 3-D polythreaded framework, in which each 2-D wave-like net is formed by the intersection, at the shared Co nodes, of the 1-D left- and right-handed single-helical (H2L2)2− chains and the 1-D bibp meso-helices. Furthermore, the thermal and photoluminescent properties of 1 have also been studied.
title: 02_0820
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Two new entangled complexes based on 4,4’-bis(1-imidazolyl)biphenyl: Syntheses, structures, thermal and photoluminescent properties
Creators: name: Wang, Yue
name: Qi, Yan
name: Li, Qun
name: Lu, Zhou
name: Wang, Yanwei
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Physics
Engineering
Biochemistry
Biophysics

description: Two new entangled complexes, [Zn(bibp)(L1)]·0.25H2O (1) and [Co(bibp)(H2L2)] (2) (bibp = 4,4’-bis(1-imidazolyl)biphenyl, H2L1 = 4,4’-(2,2’-oxybis(ethane-2,1-diyl)bis(oxy))dibenzoic acid and H4L2 = 5,5’-(2,2’-oxybis(ethane-2,1-diyl)bis(oxy))diisophthalic acid), have been synthesized hydrothermally. Complex 1 features a new uninodal 4-connected (65•8) net with vertex symbol 6·6·6·6·62·82, which is different from all that exhibit uninodal 4-connected (65•8) nets found in the literature, including cds, dmp, ict, mok, unl and unm. Three of these nets interpenetrate. Complex 2 shows an unusual 3-fold 2D→3D polythreaded framework, in which each 2D wave-like net is formed by the intersection, at the shared Co nodes, of the 1D left- and right-handed single-helical (H2L2)2- chains and the 1D bibp meso-helices. Furthermore, the thermal and photoluminescent properties of 1 have also been studied.
Na alvorada de uma nova era: problemas bioéticos e ecoéticos
Creators: name: Malcata, F. Xavier
Publisher: name: Didaskalia
Year: 1999

description: Didaskalia, v. 29 n. 1-2 (1999): In Honorem D. José Policarpo: Patriarca de Lisboa e Magno Chanceler da Universidade Católica Portuguesa
Fly menace and its role in animal health
Creators: name: Angeline Felicia Bora C*., Mathivathani C*
Publisher: name: trends in Agriculture Science
Year: 2024

description: During the summer season, India, being a tropical country, faces significant challenges due to increased fly attacks, posing threats to the well-being and productivity of dairy animals. These attacks not only jeopardize animal welfare but also result in financial losses, as the animals' distress leads to disruptions in feeding and a decrease in milk production. While conventional insecticides are commonly used for fly control, concerns regarding safety and the development of insecticide resistance highlight the need for alternative strategies. Consequently, in an effort to address the issue of insecticide resistance, there is a growing exploration of plant extracts and oils, such as Allium, Azadirachta, Cymbopogon, Eucalyptus, Pogostemon, Mentha, and Ricinus. These substances contain bioactive compounds capable of exerting diverse modes of action to prevent the development of resistance.
Deus misericors na tragicomédia Iosephus do P. Luís da Cruz, S.J.
Creators: name: Melo, António
Publisher: name: Didaskalia
Year: 2003

description: Didaskalia, v. 33 n. 1-2 (2003): In Memoriam Professor Doutor P. Manuel Isidro Araújo Alves
Spontaneous cell cycle synchronisation
Creators: name: Highmore, Roger
Publisher: name: figshare
Year: 2019
Subjects: subject: 29901 Biological Physics
subject: FOS: Biological sciences
subject: Cell Biology
subject: 60103 Cell Development, Proliferation and Death
subject: 60402 Cell and Nuclear Division
subject: 29902 Complex Physical Systems
subject: FOS: Physical sciences

description: We suggest that it may be possible for the cell cycles of neighboring biological cells to become spontaneously synchronized, e.g., in the presence of defects or disease. We are not proposing that spontaneous synchronization of cycles between neighboring cells is necessarily common or permanent. Rather, we suggest that temporary islands or “domains” of cells with synchronized cell cycles can form and exhibit collective behavior for some time, before disappearing. We suggest that a cell with faulty DNA whose cycle is synchronized with those of surrounding healthy cells may be dragged past the G1/S and G2/M checkpoints even if, in isolation, it would be stalled to allow repair or marking for apoptosis.
Synchronisation may occur if cell cycle oscillations are coupled with receipt and transmission of messages at cell membranes. Storms of inter-cell messages could cause collaborative cell cycling and synchronised cell growth, which may in turn make it easier for clusters of cells to cycle together than it is for lone cells to cycle in isolation.

We sketch a model where a single, possibly damaged, cell might evolve to form a domain composed of coupled cells.
A TiO2@{Mo368} composite: synthesis, characterization, and application in dye-sensitized solar cells
Creators: name: Wang, Yanhua
name: Li, Jiansheng
name: Sang, Xiaojing
name: Chen, Weilin
name: Su, Zhongmin
name: Wang, Enbo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Microbiology
subject: FOS: Biological sciences
subject: Physics
subject: Biophysics

description: The high-nuclear cluster compound Na48[HxMo368O1032(H2O)240(SO4)48]·ca.1000H2O (denoted as {Mo368}) represents the known nanoscale hedgehog-type cluster anion with the diameter of approximately 6 nm. Herein, a TiO2@{Mo368} composite was prepared through a sol–gel process for the first time. SEM, XPS, and UV–vis spectra were employed to characterize their chemical composition and structures. Meanwhile, the as-obtained composite was further mixed with P25 (Degussa P25 titania photocatalyst) then applied as the photoanodes of dye-sensitized solar cells (DSSCs); the results showed that DSSCs with the P25-TiO2@{Mo368}-based photoanodes exhibited better performance than that with pure P25-based photoanodes, which was due to less carrier recombination and longer electron lifetime in the former DSSCs by the results from analysis of dark current measurement, electrochemical impedance spectroscopy, and open-circuit voltage decay curve.
title: 02_1666
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
A TiO2@{Mo368} composite: Synthesis, characterization and application in dye-sensitized solar cells
Creators: name: Wang, Yanhua
name: Li, Jiansheng
name: Sang, Xiaojing
name: Chen, Weilin
name: Su, Zhongmin
name: Wang, Enbo
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Microbiology
subject: FOS: Biological sciences
subject: Physics
subject: Biophysics

description: The high-nuclear cluster compound Na48[HxMo368O1032(H2O)240(SO4)48]·ca.1000H2O (denoted as {Mo368}) represents the known nanoscale hedgehog-type cluster anion with the diameter of approximately 6 nm. Herein, a TiO2@{Mo368} composite was prepared through a sol-gel process for the first time. SEM, XPS and UV-vis spectra were employed to characterize their chemical composition and structures. Meanwhile, the as-obtained composite was further mixed with P25 (Degussa P25 titania photocatalyst) then applied as the photoanodes of dye-sensitized solar cells (DSSCs); the results showed that DSSCs with the P25-TiO2@{Mo368}-based photoanodes exhibited better performance than that with pure P25-based photoanodes, which was due to less carrier recombination and longer electron lifetime in the former DSSCs by the results from analysis of dark current measurement, electrochemical impedance spectroscopy and open-circuit voltage decay curve.
A TiO2@{Mo368} composite: synthesis, characterization, and application in dye-sensitized solar cells
Creators: name: Wang, Yanhua
name: Li, Jiansheng
name: Sang, Xiaojing
name: Chen, Weilin
name: Su, Zhongmin
name: Wang, Enbo
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Microbiology
subject: FOS: Biological sciences
subject: Physics
subject: Biophysics

description: The high-nuclear cluster compound Na48[HxMo368O1032(H2O)240(SO4)48]·ca.1000H2O (denoted as {Mo368}) represents the known nanoscale hedgehog-type cluster anion with the diameter of approximately 6 nm. Herein, a TiO2@{Mo368} composite was prepared through a sol–gel process for the first time. SEM, XPS, and UV–vis spectra were employed to characterize their chemical composition and structures. Meanwhile, the as-obtained composite was further mixed with P25 (Degussa P25 titania photocatalyst) then applied as the photoanodes of dye-sensitized solar cells (DSSCs); the results showed that DSSCs with the P25-TiO2@{Mo368}-based photoanodes exhibited better performance than that with pure P25-based photoanodes, which was due to less carrier recombination and longer electron lifetime in the former DSSCs by the results from analysis of dark current measurement, electrochemical impedance spectroscopy, and open-circuit voltage decay curve.
One Word: Navier-Stokes..pdf
Creators: name: Wright, Nicholas R.
Publisher: name: figshare
Year: 2018
Subjects: subject: 50102 Ecosystem Function
subject: FOS: Earth and related environmental sciences
subject: 10111 Real and Complex Functions (incl. Several Variables)
subject: FOS: Mathematics
subject: 10108 Operator Algebras and Functional Analysis
subject: 10202 Biological Mathematics
subject: 10205 Financial Mathematics
subject: 10599 Mathematical Physics not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified

description: We prove the Navier-Stokes equations, by means of the Metabolic Theory of Ecology and the Rule of 72. Macroecological theories are proof to the Navier-Stokes equations. A solution could be found using Kleiber’s Law. Measurement is possible through the heat calorie. A Pareto exists within the Navier-Stokes equations. This is done by superposing dust solutions onto fluid solutions. In summary, the Navier-Stokes equations require a theoretical solution. The Metabolic Theory of Ecology, along with Kleiber’s Law, form a theory by such standards.
Once-weekly dipeptidyl peptidase-4 inhibitors for type 2 diabetes: a systematic review and meta-analysis
Creators: name: Stoimenis, Dimitrios
name: Karagiannis, Thomas
name: Katsoula, Anastasia
name: Athanasiadou, Eleni
name: Kazakos, Kyriakos
name: Bekiari, Eleni
name: Matthews, David R.
name: Tsapas, Apostolos
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objective: To assess the efficacy and safety of omarigliptin and trelagliptin, novel dipeptidyl peptidase-4 inhibitors administered once-weekly (DPP-4i QW). Methods: We systematically searched for placebo- and active-controlled randomized trials in adults with type 2 diabetes mellitus. Results: Fifteen primary studies with 5709 participants were included. DPP-4i QW were more effective than placebo in reducing hemoglobin A1c (HbA1c) (Weighted Mean Difference (WMD) −0.63%; 95% CI −0.80, −0.46; I2 = 84%) and had a similar glucose-lowering effect with daily DPP-4i (WMD 0.01%; −0.08, 0.11%; I2 = 34%). Omarigliptin was less effective compared with oral antidiabetic agents, other than daily DPP-4i, (WMD 0.24%; 0.10, 0.38; I2 = 12%). Omarigliptin did not affect body weight (WMD versus placebo 0.60 kg; 0.25, 0.96; I2 = 0%). Risk for any hypoglycemia was similar between DPP-4i QW and placebo (Odds Ratio 1.32; 0.78, 2.22; I2 = 0%). Incidence of other adverse events did not differ between DPP-4i QW and control. Conclusions: DPP-4i QW were superior to placebo and similar to daily DPP-4i in terms of glycemic control, and were not associated with any specific adverse events. There is limited comparative effectiveness evidence against other agents, while their effect on hard clinical safety outcomes is unknown.
title: Rapport Chaire d'excellence Aristote Randa Ismail
Creators: name: Sophie Bouffier (MMSH)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Rapport relatif au projet de recherche réalisé par Randa Ismail, dans le cadre de la Chaire d'excellence Aristote.
Supplementary Material: Comparative genomics of apomictic root-knot nematodes: hybridization, ploidy, and dynamic genome change
Creators: name: Szitenberg, Amir
name: Salazar-Jaramillo, Laura
name: Blok, Vivian C.
name: Laetsch, Dominik R.
name: Soumi Joseph
name: Williamson, Valerie M.
name: Blaxter, Mark L.
name: Lunt, David H.
Publisher: name: figshare
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: AbstractThe Root-Knot Nematodes (RKN; genus Meloidogyne) are important plant parasites causing substantial agricultural losses. The Meloidogyne incognita group (MIG) of species, most of which are obligatory apomicts (mitotic parthenogens), are extremely polyphagous and important problems for global agriculture. While understanding the genomic basis for their variable success on different crops could benefit future agriculture, analyses of their genomes pose challenges due to complex evolutionary histories that may incorporate hybridization, ploidy changes, and chromosomal fragmentation. Here we sequence 19 genomes, representing five species of key RKN collected from different geographic origins. We show that a hybrid origin that predated speciation within the MIG has resulted in each species possessing two divergent genomic copies. Additionally, the MIG apomicts are hypotriploids, with a proportion of one genome present in a second copy, and this proportion varies among species. The evolutionary history of the MIG genomes is revealed to be very dynamic, with non-crossover recombination both homogenising the genomic copies, and acting as a mechanism for generating divergence between species. Interestingly, the automictic MIG species M. floridensis differs from the apomict species in that it has become homozygous throughout much of its genome.
Additional file 1 of Aligning intuition and theory: enhancing the replicability of behaviour change interventions in cancer genetics
Creators: name: Taylor, Natalie
name: Healey, Emma
name: Morrow, April
name: Greening, Sian
name: Wakefield, Claire E.
name: Warwick, Linda
name: Williams, Rachel
name: Tucker, Katherine M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Supplementary File 1. The TIDieR (Template for Intervention Description and Replication) Checklist.