cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Трудности диагностики ТТГ-продуцируюшей аденомы гипофиза (тиреотропиномы). Клинический случай
Creators: name: Дружинина Александра Сергеевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: ТИРЕОТРОПИНОМА
МАКРОАДЕНОМА
ГИПОФИЗ
THYROTROPINOMA
MACROADENOMA
PITUITARY

description: Гормонально-активные аденомы составляют 75% всех аденом гипофиза. Тиреотропинома самая редкая гормональноактивная опухоль, составляет 1-2% от общего числа аденом. Как правило, это доброкачественная макроаденома гипофиза, продуцирующая только тиреотропный гормон, однако в 25% случаев опухоль обладает смешанной гормональной секрецией. Главными проявлениями заболевания являются симптомы тиреотоксикоза, головные боли и нарушения полей зрения. Нередко аденому обнаруживают спустя несколько лет от начала заболевания. В данной работе представляется клинический случай мужчины 51 года с тиреотропиномой смешанной секреции.Thyrotropinoma is a rare benign pituitary tumor. It appears only in 1-2% cases among all the pituitary hormone producing adenomas. Usually thyrotropinoma produces only one hormone, but sometimes (in 25%) it can produce many. Commonly the first symptoms of the disease are headache, visual disorders and signs of thyrotoxicosis. We present a clinical case of a 51-year-old man with thyrotropinoma with plural hormone producing.
Locomotion in complex fluids: Integral theorems
Creators: name: Lauga, Eric
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: The biological fluids encountered by self-propelled cells display complex microstructures and rheology. We consider here the general problem of low-Reynolds number locomotion in a complex fluid. {Building on classical work on the transport of particles in viscoelastic fluids,} we demonstrate how to mathematically derive three integral theorems relating the arbitrary motion of an isolated organism to its swimming kinematics {in a non-Newtonian fluid}. These theorems correspond to three situations of interest, namely (1) squirming motion in a linear viscoelastic fluid, (2) arbitrary surface deformation in a weakly non-Newtonian fluid, and (3) small-amplitude deformation in an arbitrarily non-Newtonian fluid. Our final results, valid for a wide-class of {swimmer geometry,} surface kinematics and constitutive models, at most require mathematical knowledge of a series of Newtonian flow problems, and will be useful to quantity the locomotion of biological and synthetic swimmers in complex environments.
Spatially Distinct Neutrophil Responses within the Inflammatory Lesions of Pneumonic Plague
Creators: name: Goldman, William E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACT During pneumonic plague, the bacterium Yersinia pestis elicits the development of inflammatory lung lesions that continue to expand throughout infection. This lesion development and persistence are poorly understood. Here, we examine spatially distinct regions of lung lesions using laser capture microdissection and transcriptome sequencing (RNA-seq) analysis to identify transcriptional differences between lesion microenvironments. We show that cellular pathways involved in leukocyte migration and apoptosis are downregulated in the center of lung lesions compared to the periphery. Probing for the bacterial factor(s) important for the alteration in neutrophil survival, we show both in vitro and in vivo that Y. pestis increases neutrophil survival in a manner that is dependent on the type III secretion system effector YopM. This research explores the complexity of spatially distinct host-microbe interactions and emphasizes the importance of cell relevance in assays in order to fully understand Y. pestis virulence. IMPORTANCE Yersinia pestis is a high-priority pathogen and continues to cause outbreaks worldwide. The ability of Y. pestis to be transmitted via respiratory droplets and its history of weaponization has led to its classification as a select agent most likely to be used as a biological weapon. Unrestricted bacterial growth during the initial preinflammatory phase primes patients to be infectious once disease symptoms begin in the proinflammatory phase, and the rapid disease progression can lead to death before Y. pestis infection can be diagnosed and treated. Using in vivo analyses and focusing on relevant cell types during pneumonic plague infection, we can identify host pathways that may be manipulated to extend the treatment window for pneumonic plague patients.
Asian Zika virus can acquire generic African-lineage mutations during in utero infection
Creators: name: Sabi, Ahmad Jawad
name: Singh, Prince Pal
name: Trus, Ivan
name: Le, Nguyen Phuong Khanh
name: Karniychuk, Uladzimir
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: The Zika virus 2015 epidemic showed an unusual phenotype for human flaviviruses, specifically fetal infection. We previously showed that in utero inoculation with the Asian Zika virus isolated from the human sample causes persistent infection in porcine fetuses. Here, we characterized the evolution of the Asian Zika virus in the fetal brain and placenta. Interestingly, the Asian Zika virus acquired generic African lineage K101R (A408G) and R1609K (G4932A) mutations during in utero infection. Both African mutations were nonsynonymous and had a high frequency of nearly 100% in the fetal brain. Then, we synthetically generated the wild-type Asian variant and fetal brain-specific variant with generic African-lineage K101R and R1609K mutations. In mosquito C6/36 cells, but not in human and pig cells, the fetal brain-specific variant showed higher virus loads compared to the Asian wild-type prototype. While in utero infection with both variants caused comparable virus loads in the placenta and amniotic fluids, fetuses injected with the fetal brain-specific variant had the trend to higher virus loads in lymph nodes. Also, introduced K101R and R1609K mutations were stable and had high nearly 100% frequency at 28 days after in utero inoculation in both directly injected and trans-infected fetuses. These findings evoke concerns because Zika persists in pig herds and mosquitoes on farms in Mexico. It will be essential to identify how persistent in utero infection affects virus evolution and whether in utero-emerged Zika variants have the potential for shedding into the environment, more efficient transmission, and more aggressive infection phenotypes.
Monthly data of environmental variables included in the final generalized linear models of meiofauna in Quebrada Prieta, Luquillo Experimental Forest, Puerto Rico
Creators: name: Santiago-Vera, Josué
name: Ramírez, Alonso
Publisher: name: Zenodo
Year: 2022

description: Monthly data of environmental variables included in the final generalized linear models of meiofauna in Quebrada Prieta, Luquillo Experimental Forest, Puerto Rico
Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs
Creators: name: Toth, Cynthia L.
name: Vickers, Kasey C.
name: Kaneko, Shuichi
name: Sethupathy, Praveen
name: Honda, Masao
name: Dinh, Timothy A.
name: Kurtz, C. Lisa
name: Struck, Benjamin R.
name: Selitsky, Sara R.
name: Lemon, Stanley M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: ABSTRACT Chronic hepatitis B (CHB), chronic hepatitis C (CHC), and associated hepatocellular carcinoma (HCC) are characterized by cholesterol imbalance and dyslipidemia; however, the key regulatory drivers of these phenotypes are incompletely understood. Using gene expression microarrays and high-throughput sequencing of small RNAs, we performed integrative analysis of microRNA (miRNA) and gene expression in nonmalignant and matched cancer tissue samples from human subjects with CHB or CHC and HCC. We also carried out follow-up functional studies of specific miRNAs in a cell-based system. These studies led to four major findings. First, pathways affecting cholesterol homeostasis were among the most significantly overrepresented among genes dysregulated in chronic viral hepatitis and especially in tumor tissue. Second, for each disease state, specific miRNA signatures that included miRNAs not previously associated with chronic viral hepatitis, such as miR-1307 in CHC, were identified. Notably, a few miRNAs, including miR-27 and miR-224, were components of the miRNA signatures of all four disease states: CHB, CHC, CHB-associated HCC, and CHC-associated HCC. Third, using a statistical simulation method (miRHub) applied to the gene expression data, we identified candidate master miRNA regulators of pathways controlling cholesterol homeostasis in chronic viral hepatitis and HCC, including miR-21, miR-27, and miR-33. Last, we validated in human hepatoma cells that both miR-21 and miR-27 significantly repress cholesterol synthesis and that miR-27 does so in part through regulation of the gene that codes for the rate-limiting enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase ( HMGCR ). IMPORTANCE Hepatitis B virus (HBV) and hepatitis C virus (HCV) are phylogenetically unrelated hepatotropic viruses that persistently infect hundreds of millions of people world-wide, often leading to chronic liver disease and hepatocellular carcinoma (HCC). Chronic hepatitis B (CHB), chronic hepatitis C (CHC), and associated HCC often lead to cholesterol imbalance and dyslipidemia. However, the regulatory mechanisms underlying the dysregulation of lipid pathways in these disease states are incompletely understood. MicroRNAs (miRNAs) have emerged as critical modulators of lipid homeostasis. Here we use a blend of genomic, molecular, and biochemical strategies to identify key miRNAs that drive the lipid phenotypes of chronic viral hepatitis and HCC. These findings provide a panoramic view of the miRNA landscape in chronic viral hepatitis, which could contribute to the development of novel and more-effective miRNA-based therapeutic strategies.
Additional file 1 of A global overview of healthcare workers’ turnover intention amid COVID-19 pandemic: a systematic review with future directions
Creators: name: Poon, Yuan-Sheng Ryan
name: Lin, Yongxing Patrick
name: Griffiths, Peter
name: Yong, Keng Kwang
name: Seah, Betsy
name: Liaw, Sok Ying
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Science Policy

description: Additional file 1. Detailed search strategy for all databases.
Реальные возможности и перспективы применения метформина у больных с нарушением углеводного обмена
Creators: name: Караманян Наира Вартановна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: САХАРНЫЙ ДИАБЕТ ТИПА 2
МЕТФОРМИН
ОЖИРЕНИЕ
СТАРЕНИЕ
ОНКОЛОГИЯ
TYPE 2 DIABETES MELLITUS
METFORMIN
OBESITY
AGING
ONCOLOGY

description: Метформин является одним из широко применяемых сахароснижающих препаратов в управлении сахарным диабетом типа 2 (СД2). Сахароснижающий механизм хорошо изучен, также есть данные о его кардиопротективном и противоопухолевом эффектах. Рассматривается возможность использования метформина в профилактике СД2 и лечении ожирения, а также в качестве препарата, способного замедлять процесс старения организма и продлевать жизнь. Препарат может применяться у пациентов с нарушениями функции печени и почек, что важно, учитывая возможность поражения этих органов при СД2.Metformin is one of the most wideLy used antidiabetic drugs in the management of type 2 diabetes. The mechanism of action is weLL described, there are evidence of cardioprotective, antitumor and antiaging properties of the metformin. Moreover there areexpectations for preventive usage of type 2 diabetes and for treatment of obesity. The possibiLity of use metformin in patient with impaired Liver and kidney functions is other benefit of the drug.
Diverse modes of Drosophila tracheal fusion cell transcriptional regulation
Creators: name: Crews, Stephen T.
name: Jiang, Lan
name: Pearson, Joseph C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Drosophila tracheal fusion cells play multiple important roles in guiding and facilitating tracheal branch fusion. Mechanistic understanding of how fusion cells function during development requires deciphering their transcriptional circuitry. In this paper, three genes with distinct patterns of fusion cell expression were dissected by transgenic analysis to identify the cis regulatory modules that mediate their transcription. Bioinformatic analysis involving phylogenetic comparisons coupled with mutational experiments were employed. The dysfusion bHLH-PAS gene was shown to have two fusion cell cis-regulatory modules; one driving initial expression and another autoregulatory module to enhance later transcription. Mutational dissection of the early module identified at least four distinct inputs, and included putative binding sites for ETS and POU homeodomain proteins. The ETS transcription factor Pointed mediates the transcriptional output of the branchless/breathless signaling pathway, suggesting that this pathway directly controls dysfusion expression. Fusion cell cis-regulatory modules of CG13196 and CG15252 require two Dysfusion:Tango binding sites, but additional sequences modulate the breadth of activation in different fusion cell classes. These results begin to decode the regulatory circuitry that guides transcriptional activation of genes required for fusion cell morphogenesis.
Влияние метформина на уровень гомоцистеина в крови и функцию эндотелия сосудов у пациентов с сахарным диабетом типа 2
Creators: name: Косян Анюта Амаяковна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: ГОМОЦИСТЕИН
ФУНКЦИЯ ЭНДОТЕЛИЯ
ВИТАМИН В12
САХАРНЫЙ ДИАБЕТ ТИПА 2
МЕТФОРМИН
HOMOCYSTEINE
ENDOTHELIAL FUNCTION
VITAMIN B12
TYPE 2 DIABETES MELLITUS
METFORMIN

description: В статье рассматривается влияние метформина на уровень гомоцистеина в крови и на функцию эндотелия сосудов у пациентов с сахарным диабетом типа 2.This article presents effect of metformin on homocysteine blood level and vascular endothelium function in patients with type 2 diabetes mellitus.
SOX2 hypomorphism disrupts development of the prechordal floor and optic cup
Creators: name: Sulik, Kathleen
name: Langer, Lee
name: Pevny, Larysa
name: Taranova, Olena
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine how Sox2 deficiency affects the morphogenesis of the ventral diencephalon and eye, we generated a Sox2 allelic series (Sox2IR, Sox2LP, and Sox2EGFP), allowing for the generation of mice that express germline hypomorphic levels (SOX2 haploinsufficient human phenotypes. We find that Sox2 hypomorphism significantly disrupts the development of the posterior hypothalamus, resulting in an ectopic protuberance of the prechordal floor, an upregulation of Shh signaling, and abnormal hypothalamic patterning. In the anterior diencephalon, both the optic stalks and optic cups (OC) of Sox2 hypomorphic (Sox2HYP) embryos are malformed. Furthermore, Sox2HYP eyes exhibit a loss of neural potential and coloboma, a common phenotype in SOX2 haploinsufficient humans that has not been described in a mouse model of SOX2 deficiency. These results establish for the first time that germline Sox2 hypomorphism disrupts the morphogenesis and patterning of the hypothalamus, optic stalk, and the early OC, establishing a model of the development of the abnormalities that are observed in SOX2 haploinsufficient humans.
Первичная надпочечниковая недостаточность. Клинический случай
Creators: name: Куленок Светлана Геннадьевна
name: Гасанзаде Пери Адиловна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: ПЕРВИЧНАЯ НАДПОЧЕЧНИКОВАЯ НЕДОСТАТОЧНОСТЬ
БОЛЕЗНЬ АДДИСОНА
КЛИНИЧЕСКИЙ СЛУЧАЙ
PRIMARY ADRENAL INSUFFICIENCY
ADDISON''S DISEASE
CLINICAL CASE

description: Первичная хроническая надпочечниковая недостаточность довольно редко встречается в общей популяции от 40 до 110 случаев в год на 1 млн населения. Этот клинический случай описывает типичное развитие первичной надпочечниковой недостаточности у молодого мужчины, ее лечение с положительной динамикой, а также некоторые трудности в диагностике болезни Аддисона.Primary chronic adrenocortical insufficiency is quite rare in the general population it occurs 40-110 times per 1 million population on annual basis. This clinical case describes the typical development of primary adrenal insufficiency of young male, its treatment with positive dynamics, and some difficulties in diagnosing Addison's disease.
Molecular alignment and filamentation: comparison between weak and strong field models
Creators: name: Berti, N.
name: Béjot, P.
name: Wolf, J. -P.
name: Faucher, O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The impact of nonadiabatic laser-induced molecular alignment on filamentation is numerically studied. Weak and strong field model of impulsive molecular alignment are compared in the context of nonlinear pulse propagation. It is shown that the widely used weak field model describing the refractive index modification induced by impulsive molecular alignment accurately reproduces the propagation dynamics providing that only a single pulse is involved during the experiment. On the contrary, it fails at reproducing the nonlinear propagation experienced by an intense laser pulse traveling in the wake of a second strong laser pulse. The discrepancy depends on the relative delay between the two pulses and is maximal for delays corresponding to half the rotational period of the molecule.
Динамика антиоксидантного и метаболического статуса у пациентов с сахарным диабетом типа 2 и мужским гипогонадизмом на фоне андрогенотерапии
Creators: name: Рождественская Ольга Анатольевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: САХАРНЫЙ ДИАБЕТ ТИПА 2
ДЕФИЦИТ ТЕСТОСТЕРОНА
АНДРОГЕНОТЕРАПИЯ
ТЕСТОСТЕРОН-ЗАМЕСТИТЕЛЬНАЯ ТЕРАПИЯ
ОКСИДАТИВНЫЙ СТРЕСС
TYPE 2 DIABETES MELLITUS
TESTOSTERONE DEFICIENCY
ANDROGENOTHERAPY
TESTOSTERONE REPLACEMENT TREATMENT
OXIDATIVE STRESS

description: В работе продемонстрирована положительная антиоксидантная активность на фоне заместительной гормональной терапии тестостероном у пациентов с сахарным диабетом типа 2 и андрогенным дефицитом.The work demonstrated a positive antioxidant activity against the background of hormone replacement therapy with testosterone in patients with type 2 diabetes mellitus and androgen deficiency.
The structure–activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface
Creators: name: Zhong, Nan
name: Dong, Aiping
name: Arrowsmith, Cheryl H.
name: Baughman, Brandi M.
name: Norris, Jacqueline L.
name: Kireev, Dmitri B.
name: Janzen, William P.
name: Dickson, Bradley M.
name: Frye, Stephen V.
name: James, Lindsey I.
name: Camerino, Michelle A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain. In this article, we describe the development of structure-activity relationships (SAR) of a second series of potent L3MBTL3 antagonists which evolved from the structure of the chemical probe UNC1215. These compounds are selective for L3MBTL3 against a panel of methyllysine reader proteins, particularly the related MBT family proteins, L3MBTL1 and MBTD1. A co-crystal structure of L3MBTL3 and one of the most potent compounds suggests that the L3MBTL3 dimer rotates about the dimer interface to accommodate ligand binding.
Нарушение формирования пола 46,xy, синдром нечувствительности к андрогенам: клинико-лабораторная характеристика пациентов
Creators: name: Санникова Екатерина Сергеевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: НАРУШЕНИЕ ФОРМИРОВАНИЯ ПОЛА
СИНДРОМ НЕЧУВСТВИТЕЛЬНОСТИ К АНДРОГЕНАМ
АНТИМЮЛЛЕРОВ ГОРМОН

description: Цель исследования изучить клинико-лабораторную характеристику пациентов с нарушением формирования пола 46,ХҮ, синдромом нечувствительности к андрогенам. Материал и методы. В исследование включены 52 пациента, сформирована группа из 9 пациентов с нарушением формирования пола (НФП) 46,ХҮ, синдромом нечувствительности к андрогенам. Всем детям проведена оценка строения наружных половых органов, гормонального профиля, ультразвуковое исследование. Удалено 6 гонад у 3 пациентов с последующим гистологическим исследованием 2 гонад. Результаты. Пациенты были разделены на 2 группы: с парциальной и полной нечувствительностью к андрогенам. Пациенты с парциальной нечувствительностью к андрогенам имели смешанное строение наружных гениталий в 100% случаев. При полной нечувствительности к андрогенам пациенты имели строение наружных гениталий по женскому типу, и поводом для обследования в 3 (75%) из 4 случаев было обнаружение мужских гонад во время грыжесечения. Отмечена вариабельность гормональных показателей в обеих группах. Гистологическое исследование гонад выявило ткань семенника с картиной атрофии и очагами хронического воспаления без признаков сперматогенеза. Заключение. Группа пациентов с НФП 46,XY, синдромом нечувствительности к андрогенам гетерогенна по клинической картине в зависимости от степени нечувствительности к андрогенам. Несвоевременная верификация диагноза требует оптимизации алгоритма обследования пациентов.Aim. To study clinical and laboratory characteristics of patients with disorders of sex development 46,XY, androgen insensitivity syndrome. Subjects and methods. It was included 52 patients and formed group with disorders of sex development (DSD) 46,XY, androgen insensitivity syndrome. All children evaluated the structure of the external genitalia, hormonal evaluated, ultrasound examination. There was removed from 6 gonads of 3 patients with subsequent histological examination of 2 gonads. Results. All patients were divided in two groups: with complete and partial androgen insensitivity. Patients with partial androgen insensitivity syndrome had a genital ambiguity in 100%. Patients with complete androgen insensitivity syndrome had female genitalia and the reason for the survey in 75% (3/4) was the detection of male gonads at hernia repair. Gonadal examination revealed a testis tissue with a picture of atrophy and foci of chronic inflammation, without signs of spermatogenesis. Conclusion. The group of patients with DSD 46,XY, androgen insensitivity syndrome was heterogenous in clinical picture depending on the degree of insensitivity to androgens. Untimely verification of the diagnosis requires the optimization of the patient examination algorithm.
Современный взгляд на диагностику ожирения
Creators: name: Серегина Софья Сергеевна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: ОЖИРЕНИЕ
ДИАГНОСТИКА
AACE
ИНДЕКС МАССЫ ТЕЛА
OBESITY
DIAGNOSTICS
BMI

description: Ожирение является одной из основных проблем современности. Для выявления причин заболевания используются различные виды диагностики. Цель данной работы провести анализ этих методов и, исходя из их достоинств и недостатков, представить разработанную в 2014 г. классификацию, рассматривающую ожирение с точки зрения наличия или отсутствия сопутствующей патологии. Новая классификация помогает клиницистам шире взглянуть на проблему избыточной массы тела и ожирения и обеспечить индивидуальный подход к терапии.Obesity is one of the main health problems of our time. To identify the causes of the disease, various types of diagnostics are used. The aim of this work is to analyze these methods and based on their merits and demerits, to present a classification developed in 2014 that considers obesity in terms of the presence or absence of concomitant pathology. The new classification helps clinicians to take a broader look at the problem of overweight and obesity and provide an individual approach to therapy.
Pilgrimages to mineral springs between Antiquity and the Middle Ages
Creators: name: Bassani, Maddalena
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Thermalism
Sacred Places
Roman Roads
Pilgrimage

description: The article aims at analyzing two Roman archaeological contexts attested in Northern Italy characterized by the presence of thermos-mineral sources, in which sacred buildings and artifacts, as well as private structures related to pilgrims have been found. The dataset proposed can offer interesting elements to consider the pilgrimage phenomenon in a long durée perspective, and the relations with the votive activities along the three Romee routes (Via Romea Francigena, Via Romea Germanica, Via Romea Strata) throughout the centuries.
Sad Kids, Sad Media? Applying Mood Management Theory to Depressed Adolescents' Use of Media
Creators: name: Dillman Carpentier, Francesca R.
name: Forbes, Erika E.
name: Silk, Jennifer S.
name: Dahl, Ronald E.
name: Brown, Jane D.
name: Bertocci, Michele
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Mood management studies typically have found that adults will select media that enhance positive moods and reduce negative moods. In this study, adolescents diagnosed with major depressive disorder and control adolescents without psychiatric disorders were called on customized cell phones up to 4 times a day and asked about their current mood state and media use for five extended weekends across an 8-week period. Mood effects on subsequent media use, mood during media consumption, and media effects on subsequent mood were examined. Results indicated that adolescents who consumed fun media tended to do so in a way that sustained, rather than enhanced their prior positive mood levels during and after consumption-if they turned to media. Adolescents in more negative moods did not often use media to improve their moods. When they did, boys were more likely than girls to use media that ultimately reduced negative mood levels. Findings are discussed in light of the literature on mood management, adolescence, and depression.
Simultaneous optical and near-IR photometry of 4U 1957+115 - a missing secondary star
Creators: name: Hakala, Pasi
name: Muhli, Panu
name: Charles, Phil
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report the results of quasi-simultaneous optical and NIR photometry of the low-mass X-ray binary, 4U 1957+115. Our observations cover B, V, R, I, J, H and K-bands and additional time-series NIR photometry. We measure a spectral energy distribution, which can be modelled using a standard multi-temperature accretion disc, where the disc temperature and radius follow a power-law relation. Standard accretion disc theory predicts the power law exponent to be -3/4, and this yields, perhaps surprisingly, acceptable fits to our SED. Given that the source is a persistent X-ray source, it is however likely that the accretion disc temperature distribution is produced by X-ray heating, regardless of its radial dependence. Furthermore, we find no evidence for any emission from the secondary star at any wavelength. However, adding a secondary component to our model allows us to derive a 99\% lower limit of 14 or 15 kpc based on Monte Carlo simulations and using either an evolved K2 or G2V secondary star respectively. In $>$60\% of cases the distance is $>$80kpc. Such large distances favor models with a massive ($>$15 M$_{\odot}$) black hole primary. Our quasi-simultaneous J and V-band time-series photometry, together with the SED, reveals that the optical/NIR emission must originate in the same region i.e. the accretion disc. The likely extreme mass ratio supports suggestions that the accretion disc must be precessing which, depending on the length of the precession period, could play a major part in explaining the variety of optical light curve shapes obtained over the last two decades.
description: 7 pages, 4 figures, accepted for publication in MNRAS
Inappropriate Drug Use and Risk of Transition to Nursing Homes Among Community-Dwelling Older Adults
Creators: name: Byrns, Patricia J.
name: Zuckerman, Ilene H.
name: Magaziner, Jay
name: Simoni-Wastila, Linda
name: Orwig, Denise
name: Baumgarten, Mona
name: Langenberg, Patricia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Adverse events from inappropriate medications are preventable risk factors for nursing home admissions.
Additional file 1 of Microarray analysis reveals the potential molecular mechanism of Lp299v in stable coronary atherosclerotic disease
Creators: name: Fu, Zhenyang
name: Song, Xiaolei
name: Shen, Anna
name: Zhou, Tao
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. Herpes simplex virus 1 infection-related pathway. Fig. S2. Yersinia infection-related pathway. Fig. S3. The PPI network of the DEGs in the daily alcohol user group. Fig. S4. The PPI network of the DEGs in the non-daily alcohol user group. Fig. S5. The WGCNA clustered the DEGs into 4 modules, and 4 different colors were used to represent 4 different modules. Table S1. The KEGG pathway enrichment analysis of DEGs in the daily alcohol user group sorted by adjusted P-values in a descending order. Table S2. The KEGG pathway enrichment analysis of DEGs in the non-daily alcohol user group sorted by adjusted P -values in a descending order.
Rolling quantum dice with a superconducting qubit
Creators: name: Barends, R.
name: Kelly, J.
name: Veitia, A.
name: Megrant, A.
name: Fowler, A. G.
name: Campbell, B.
name: Chen, Y.
name: Chen, Z.
name: Chiaro, B.
name: Dunsworth, A.
name: Hoi, I. -C.
name: Jeffrey, E.
name: Neill, C.
name: O'Malley, P. J. J.
name: Mutus, J.
name: Quintana, C.
name: Roushan, P.
name: Sank, D.
name: Wenner, J.
name: White, T. C.
name: Korotkov, A. N.
name: Cleland, A. N.
name: Martinis, John M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: One of the key challenges in quantum information is coherently manipulating the quantum state. However, it is an outstanding question whether control can be realized with low error. Only gates from the Clifford group -- containing $π$, $π/2$, and Hadamard gates -- have been characterized with high accuracy. Here, we show how the Platonic solids enable implementing and characterizing larger gate sets. We find that all gates can be implemented with low error. The results fundamentally imply arbitrary manipulation of the quantum state can be realized with high precision, providing new practical possibilities for designing efficient quantum algorithms.
description: 8 pages, 4 figures, including supplementary material
Enhanced structural similarity : an improved structural similarity index
Creators: name: Venkataramanan, Abhinau Kumar
name: 0000-0002-3648-230X
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Structural similarity
Image quality assessment
video quality assessment
Compression

description: The Structural Similarity (SSIM) Index is a very widely used image/video quality model that continues to play an important role in the perceptual evaluation of compression algorithms, encoding recipes and numerous other image/video processing algorithms. Several public implementations of the SSIM and Multiscale-SSIM (MS-SSIM) algorithms have been developed, which differ in efficiency and performance. This “bendable ruler” makes the process of quality assessment of encoding algorithms unreliable. To address this situation, we studied and compared the functions and performances of popular and widely used implementations of SSIM, and we also considered a variety of design choices. Based on our studies and experiments, we have arrived at a collection of recommendations on how to use SSIM most effectively, including ways to reduce its computational burden
Item and Scale Differential Functioning of the Mini-Mental State Exam Assessed Using the Differential Item and Test Functioning (DFIT) Framework
Creators: name: Morales, Leo S.
name: Teresi, Jeanne A.
name: Gutierrez, Peter
name: Kleinman, Marjorie
name: Flowers, Claudia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: To illustrate the application of the Differential Item and Test Functioning (DFIT) method using English and Spanish versions of the Mini-Mental State Examination (MMSE).
Additional file 1 of The limited use of instructional design guidelines in healthcare simulation scenarios: an expert appraisal
Creators: name: de Melo, Brena C. P.
name: Falbo, Ana R.
name: Souza, Edvaldo S.
name: Muijtjens, Arno M. M.
name: Van Merriënboer, Jeroen J. G.
name: Van der Vleuten, Cees P. M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. This additional file contains the following sequence of instructions received by each rater: 1- Explanatory email, 2- Information Table Subset*1, 3- Rating Instrument Subset*1*2, 4- Additional Information Table Subset* *1 – the table subset for each article varied according to the subset to which each rater was allocated; *2 each rater received their own rating instrument with entries relating to the corresponding article subsets.
An Assessment of the Quality of Mammography Care at Facilities Treating Medically Vulnerable Populations
Creators: name: Smith-Bindman, Rebecca
name: Yankaskas, Bonnie
name: Haneuse, Sebastien J.-P. A.
name: Buist, Diana S. M.
name: Goldman, L Elizabeth
name: Kerlikowske, Karla
name: Miglioretti, Diana L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Women in medically vulnerable populations, including racial and ethnic minorities, the socioeconomically disadvantaged, and residents of rural areas, experience higher breast cancer mortality than do others. Whether mammography facilities that treat vulnerable women demonstrate lower quality of care than other facilities is unknown.
VLT observations of the asymmetric Etched Hourglass Nebula, MyCn 18
Creators: name: Clyne, N.
name: Redman, M. P.
name: Lloyd, M.
name: Matsuura, M.
name: Singh, N.
name: Meaburn, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context. The mechanisms that form extreme bipolar planetary nebulae remain unclear. Aims. The physical properties, structure, and dynamics of the bipolar planetary nebula, MyCn 18, are investigated in detail with the aim of understanding the shaping mechanism and evolutionary history of this object. Methods. VLT infrared images, VLT ISAAC infrared spectra, and long-slit optical Echelle spectra are used to investigate MyCn 18. Morpho-kinematic modelling was used to firmly constrain the structure and kinematics of the source. A timescale analysis was used to determine the kinematical age of the nebula and its main components. Results. A spectroscopic study of MyCn 18's central and offset region reveals the detailed make-up of its nebular composition. Molecular hydrogen, atomic helium, and Bracket gamma emission are detected from the central regions of MyCn 18. ISAAC spectra from a slit position along the narrow waist of the nebula demonstrate that the ionised gas resides closer to the centre of the nebula than the molecular emission. A kinematical age of the nebula and its components were obtained by the P-V arrays and timescale analysis. Conclusions. The structure and kinematics of MyCn 18 are better understood using an interactive 3-D modelling tool called shape. A dimensional and timescale analysis of MyCn 18's major components provides a possible mechanism for the nebula's asymmetry. The putative central star is somewhat offset from the geometric centre of the nebula, which is thought to be the result of a binary system. We speculate that the engulfing and destruction of an exoplanet during the AGB phase may have been a key event in shaping MyCn 18 and generating of its hypersonic knotty outflow.
description: 15 pages, 3 tables, 13 figures. Accepted for publication by A&A
Оценка влияния секреции C-пептида на показатели микроциркуляции крови у пациентов с сахарным диабетом типа 2
Creators: name: Сучкова Ольга Владимировна
name: Гурфинкель Юрий Ильич
name: Сасонко Мария Леонидовна
Publisher: name: Эндокринология: Новости. Мнения. Обучение
Year: 2017
Subjects: ЦИФРОВАЯ КАПИЛЛЯРОСКОПИЯ НОГТЕВОГО ЛОЖА
МИКРОЦИРКУЛЯЦИЯ КРОВИ
САХАРНЫЙ ДИАБЕТ ТИПА 2
ГЛИКИРОВАННЫЙ ГЕМОГЛОБИН
СЕКРЕЦИЯ С-ПЕПТИДА
РАСШИРЕНИЕ ОТДЕЛОВ КАПИЛЛЯРА (АРТЕРИАЛЬНОГО
ПЕРЕХОДНОГО
ВЕНОЗНОГО)
DIGITAL NAILFOLD CAPILLAROSCOPY
BLOOD MICROCIRCULATION
TYPE 2 DIABETES MELLITUS
GLYCATED HEMOGLOBIN
C-PEPTIDE SECRETION
ALL SEGMENTS CAPILLARY ENLARGEMENT (ARTERIAL
APEX
VENOUS SEGMENTS)

description: В работе изучаются параметры микроциркуляции крови у пациентов с сахарным диабетом типа 2 методом цифровой капилляроскопии в зависимости от уровня секреции С-пептида: в первой группе С-пептид <1000 пмоль/л, во 2-й группе С-пептид>1000 пмоль/л, в условиях одинакового гликемического контроля (8,37+0,41% в 1-й группе и 8,20+0,38 во 2-й группе) для минимизации фактора гипергликемии на сравниваемые параметры. Выявлено расширение артериального отдела (р<0,001), переходного отдела (р<0,001), венозного отдела капилляра (р<0,05) в группе с высокой секрецией С-пептида. Также пациенты 2-й группы характеризовались ожирением 34,9+0,9 кг/м2 (р<0,05) и артериальной гипертензией (р<0,001). Повышенные значения артериального давления у пациентов с высокой секрецией С-пептида демонстрируют негативное влияние высокой секреции С-пептида на свойства эндотелия магистральных сосудов, в отличие от его влияния на капиллярное звено.We evaluated microcirculation parameters in patients with diabetes mellitus type 2 by digital capillaroscopy depending on the C-peptide secretion level. 1st group included patients with C-peptide <1000 pmol/l and 2nd group was consisted of patients with C-peptide>1000 pmol/l. To minimize the effects of hyperglycemia on comparison results we formed both groups with similar glycemic control (8.37+0.41% in the 1st group and 8.20+0.38 in the 2nd group). The expansion of arterial segments (p<0.001), apex segments (p<0.001) and venous segments of the capillaries (p<0.05) were founded in the group with high C-peptide secretion. High C-peptide secretion patients were characterized by obesity 34.9+0.9 kg/m2 (p<0.05) and arterial hypertension (p<0.001). Elevated values of blood pressure in this group demonstrate the negative impact of high C-peptide secretion on the endothelium macrocirculation properties, in contrast to its effect on capillary component.
Non-coplanar and counter-rotating incommensurate magnetic order stabilized by Kitaev interactions in $γ$-Li2IrO3
Creators: name: Biffin, A.
name: Johnson, R. D.
name: Kimchi, I.
name: Morris, R.
name: Bombardi, A.
name: Analytis, J. G.
name: Vishwanath, A.
name: Coldea, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Materials that realize Kitaev spin models with bond-dependent anisotropic interactions have long been searched for, as the resulting frustration effects are predicted to stabilize novel forms of magnetic order or quantum spin liquids. Here we explore the magnetism of $γ$-Li$_2$IrO$_3$, which has the topology of a 3D Kitaev lattice of inter-connected Ir honeycombs. Using resonant magnetic x-ray diffraction we find a complex, yet highly-symmetric incommensurate magnetic structure with non-coplanar and counter-rotating Ir moments. We propose a minimal Kitaev-Heisenberg Hamiltonian that naturally accounts for all key features of the observed magnetic structure. Our results provide strong evidence that $γ$-Li$_2$IrO$_3$ realizes a spin Hamiltonian with dominant Kitaev interactions.
description: 10 pages, 7 figures
Additional file 29 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 29: Table S14 Number of deaths and total sample size for each BMI category and admission region in Table 4.
Nanoscale NMR Spectroscopy and Imaging of Multiple Nuclear Species
Creators: name: DeVience, Stephen J.
name: Pham, Linh M.
name: Lovchinsky, Igor
name: Sushkov, Alexander O.
name: Bar-Gill, Nir
name: Belthangady, Chinmay
name: Casola, Francesco
name: Corbett, Madeleine
name: Zhang, Huiliang
name: Lukin, Mikhail
name: Park, Hongkun
name: Yacoby, Amir
name: Walsworth, Ronald L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are well-established techniques that provide valuable information in a diverse set of disciplines but are currently limited to macroscopic sample volumes. Here we demonstrate nanoscale NMR spectroscopy and imaging under ambient conditions of samples containing multiple nuclear species, using nitrogen-vacancy (NV) colour centres in diamond as sensors. With single, shallow NV centres in a diamond chip and samples placed on the diamond surface, we perform NMR spectroscopy and one-dimensional MRI on few-nanometre-sized samples containing $^1$H and $^{19}$F nuclei. Alternatively, we employ a high-density NV layer near the surface of a diamond chip to demonstrate wide-field optical NMR spectroscopy of nanoscale samples containing $^1$H, $^{19}$F, and $^{31}$P nuclei, as well as multi-species two-dimensional optical MRI with sub-micron resolution. For all diamond samples exposed to air, we identify a ubiquitous $^1$H NMR signal, consistent with a $\sim 1$ nm layer of adsorbed hydrocarbons or water on the diamond surface and below any sample placed on the diamond. This work lays the foundation for nanoscale NMR and MRI applications such as studies of single proteins and functional biological imaging with subcellular resolution, as well as characterization of thin films with sub-nanometre resolution.
The Effect of Hospital and Surgeon Volume on Racial Differences in Recurrence-Free Survival After Radical Prostatectomy
Creators: name: Gooden, Kyna M.
name: Taylor, Yhenneko J.
name: Carson, April P.
name: Carpenter, William R.
name: Godley, Paul A.
name: Peacock, Sharon
name: Howard, Daniel L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: This study investigates associations between hospital and surgeon volume, and racial differences in recurrence after surgery for prostate cancer.
Additional file 1 of Early antibiotic therapy is associated with a lower probability of successful liberation from mechanical ventilation in patients with severe acute exacerbation of chronic obstructive pulmonary disease
Creators: name: Deniel, G.
name: Cour, M.
name: Argaud, L.
name: Richard, J. C.
name: Bitker, L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Additional figures and tables.
Components of Recommended Asthma Care and the Use of Long-Term Control Medication Among Urban Children With Asthma
Creators: name: Stingone, Jeanette Anne
name: Claudio, Luz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Previous research has documented an underuse of long-term control medications among children with asthma, in non-adherence with national guidelines on asthma care.
Inventory of Data Sources for Estimating Health Care Costs in the United States
Creators: name: Ibuka, Yoko
name: Lipscomb, Joseph
name: Brown, Martin L.
name: Yabroff, K Robin
name: Russell, Louise B.
name: Barnett, Paul G.
name: Lawrence, William F.
name: Lund, Jennifer L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To develop an inventory of data sources for estimating health care costs in the United States and provide information to aid researchers in identifying appropriate data sources for their specific research questions.
Additional file 28 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 28: Table S13 Number of deaths and total sample size for each BMI category and admission period in Table 3.