cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Terpenoids of Linaria alpina (L.) Mill. from Dolomites, Italy
Creators: name: A. Venditti
name: M. Serafini
name: M. Nicoletti
name: A. Bianco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: This paper reports the first phytochemical analysis of Linaria alpina (L.) Mill., collected in Dolomites (Italy), a species characteristic of mountain environment. Besides aucubin (4), which is rare in the subgenus Antirrhineae of Plantaginaceae, mainly acidic compounds were found, i.e. oleanolic acid (1), ursolic acid (2) maslinic acid (3) and shikimic acid (5). The pentacyclic triterpenes of L. alpina resulted in relatively high content, whereas flavonoids resulted in low content.
Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108
Creators: name: Sasiphimol Sawadsitang
name: Wiyada Mongkolthanaruk
name: Nuttika Suwannasai
name: Sirirath Sodngam
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Genetics
subject: Microbiology
subject: Biochemistry

description: Xylaria cf. cubensis PK108 was identified by its distinctive morphological characteristics and its internal transcribed spacers sequence analysis. The chromatographic separation and structural elucidation based on spectroscopic analysis of fungal crude extracts led to 10 compounds; tryptoquivaline L (1), fiscalin C (2), epi-fiscalin C (3), cytochalasin D (4), ergosterol (5), ergosterol peroxide (6), chevalone C (7), xylaranol B (8), helvolic acid (9) and cyclo-(l-Pro-l-Leu) (10). The bioassay screening showed that 4 displayed cytotoxicity against KB and NCI-H187 cancer cell lines with IC50 values of 3.25 and 5.95 μg mL− 1. 6 exhibited cytotoxicity against NCI-H187 with an IC50 value of 5.81 μg mL− 1. 7 and 9 showed antimalarial activity with IC50 values of 25.00 and 6.25 μg mL− 1, respectively. This result establishes Xylaria as broad spectrum bioactive compound producers.
Two new compounds from cultures of the basidiomycete Antrodiella albocinnamomea
Creators: name: Chen, Zi-Ming
name: Shun-Lin Wang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: A new linear triterpene (1), and a new sesquiterpene (2), together with a known compound methyl indole-3-carboxylate (3) were isolated from the crude extract of Antrodiella albocinnamomea. The structures of the new compounds 1–2 were determined by comprehensive spectroscopic analysis. Compound 1 exhibited signiﬁcant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 value of 1.0 μg/mL.
Terpenoids of Linaria alpina (L.) Mill. from Dolomites, Italy
Creators: name: A. Venditti
name: M. Serafini
name: M. Nicoletti
name: A. Bianco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: This paper reports the first phytochemical analysis of Linaria alpina (L.) Mill., collected in Dolomites (Italy), a species characteristic of mountain environment. Besides aucubin (4), which is rare in the subgenus Antirrhineae of Plantaginaceae, mainly acidic compounds were found, i.e. oleanolic acid (1), ursolic acid (2) maslinic acid (3) and shikimic acid (5). The pentacyclic triterpenes of L. alpina resulted in relatively high content, whereas flavonoids resulted in low content.
D1.9 - FAIR recommendations and cooperations report version 2
Creators: name: Le Franc, Yann
Publisher: name: Zenodo
Year: 2023
Subjects: Ontology
FAIR principles
collaboration
FAIRSharing

description: The FAIR principles provide a set of generic principles for data management and in particular for supporting machine-actionability toward automation of data management and data analysis pipelines. Ontologies are key elements for the implementation of interoperability in the context of the FAIR principles. OntoCommons aims at defining a semantic interoperability framework to support the documentation of industrial data with ontologies. This framework is key to integrate the FAIR principles within the context of industry.This document summarizes our collaborative efforts to connect OntoCommons together with FAIR related projects within the EOSC landscape as well as our activities to raise awareness of the industrial partners on FAIR and the registration of the project outputs into the FAIRSharing registry.
Experimental investigation of cement mortar reinforced with natural fibers
Creators: name: Kareche, A.
name: Agoudjil, B.
name: Channouf, N.
name: Boudenne, A.
Publisher: name: Academic Journal of Civil Engineering
Year: 2017

description: The big demand of energy in the building is one of several factors that have an impact on our life and environment. One of the promising alternatives to this problem is the thermal insulation of building with the use of biomaterials from vegetal and agriculture waste. These biomaterials need low energy consumption for their production, reduce CO2 emission and are renewable materials. In this work, several samples constituted with cements, sand and reinforced with a several concentration (from 5 wt. % to 30 wt. %) and size of date palm fibers (DPF) were prepared. Compressive strength and thermal conductivity measurement were conducted on these biomaterial samples. The results showed that the compressive strength and thermal conductivity decrease with the increase of DPF content. An optimal composition of this bioconcrete was find taking into account mechanical and thermal properties according RILEM classification. Finally, we have shown that our material may be great potential for use as an insulating material with favorable compression strength in the field of construction, as it can also improve the comfort level and participate to solve the problem initially noted.
description: Academic Journal of Civil Engineering, Vol 35 No 2 (2017): Special Issue - ICBBM 2017
Two new compounds from cultures of the basidiomycete Antrodiella albocinnamomea
Creators: name: Chen, Zi-Ming
name: Shun-Lin Wang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: A new linear triterpene (1), and a new sesquiterpene (2), together with a known compound methyl indole-3-carboxylate (3) were isolated from the crude extract of Antrodiella albocinnamomea. The structures of the new compounds 1–2 were determined by comprehensive spectroscopic analysis. Compound 1 exhibited signiﬁcant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 value of 1.0 μg/mL.
Antibacterial alkaloids from Artabotrys crassifolius Hook.f. & Thomson
Creators: name: Tan, Kok Kwan
name: Khoo, Teng Jing
name: Mogana Rajagopal
name: Wiart, Christophe
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: Chloroform extract of bark of Artabotrys crassifolius Hook.f. & Thomson exhibited antibacterial activities against both American Type Culture Collection and clinical bacterial strains in vitro with zones of inhibition ranging from 7 to 14 mm. Further analysis of this extract yielded artabotrine, liridine, lysicamine and atherospermidine. Artabotrine displayed a broad array of antibacterial activity mostly against Gram-positive bacteria with minimum inhibitory concentration (MIC) values ranging from 1.25 μg/mL to 5 μg/mL. Of note, artabotrine, liridine and lysicamine are bactericidal against Gram-negative extended-spectrum beta-lactamase-producing Klebsiella with MIC values equal 2.5, 2.5 and 10 μg/mL, respectively, and minimum bactericidal concentrations values equal to 2.5, 5 and 20 μg/mL.
Abeliaside, a new phenolic glucoside from Abelia triflora
Creators: name: Areej Mohammad Al-Taweel
name: Shagufta Perveen
name: Fawzy, Ghada Ahmed
name: Khan, Afsar
name: Mehmood, Rashad
name: Malik, Abdul
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: A new phenolic glucoside, abeliaside, along with four known compounds, 5,6,7,4′-tetrahydroxy flavones, caffeic acid, 4-O-caffeoylquinic acid and caffeic acid glucoside, was isolated from the leaves of Abelia triflora R. Br. (Caprifoliaceae). The structure of the new compound was elucidated by different spectroscopic techniques. Compounds 1–5 were assayed for their anticancer activities against two cancerous human cell lines, MCF-7 and PC-3 cells, and normal Vero cell line using the crystal violet staining method. From the results it could be seen that caffeic acid possessed the highest anticancer effect against MCF-7 (IC50: 17 μg/mL) and PC-3 (IC50: 20.1 μg/mL) compared to vinblastine sulphate as reference drug (IC50: 4.6, 2.8 μg/mL). The other compounds showed weak anticancer activity on both cell lines.
Superabsorbent biopolymers for mitigating autogenous shrinkage in cement-based materials
Creators: name: Aday, A. N.
name: Srubar III, W. V.
Publisher: name: Academic Journal of Civil Engineering
Year: 2017

description: Availability of water plays an essential role in the hydration of ordinary portland cement. At low water-to-cement (w/c) ratios, for example, hydration processes can rapidly deplete water. The increased demand for more water exacerbates surface tension-induced stresses within fine capillary pores, which causes shrinkage of the cement paste. This phenomenon, termed autogenous shrinkage, is often prevented with sufficient curing, namely by keeping the surface of the concrete continuously wet. However, such conventional curing methods are not sufficient for ultra-high-performance concretes, which are produced with very low w/c ratios. In these applications, autogenous shrinkage is mitigated via the use of internal curing approaches, either by inclusion of prewetted lightweight aggregates or superabsorbent polymers (SAPs). SAPs are ultra-hydrophilic polymer networks capable of absorbing 100,000% of their dry weight in water. A variety of acrylic-based monomers are typically employed in the preparation of SAPs, as are a number of aggressive solvents and time- and energy-intensive polymerizations. This paper presents recent experimental efforts on synthesizing and characterizing superabsorbent polymers from biorenewable resources and principles of green chemistry. In this work, the chemical synthesis and physical swelling of superabsorbent biopolymers are investigated in (a) water and (b) synthetic concrete pore solutions. Results demonstrate that biobased SAPs that absorb in excess of 20,000% their weight in water can be synthesized using ambient-condition polymerizations and green solvents, thus offering a potential biobased solution to successfully mitigating autogenous shrinkage in ordinary portland cement paste and mortars.
description: Academic Journal of Civil Engineering, Vol 35 No 2 (2017): Special Issue - ICBBM 2017
Golden Tides: Problem or Golden Opportunity? The Valorisation of Sargassum from Beach Inundations.
Creators: name: Milledge, John J.
name: Harvey, Patricia J.
Publisher: name: UNESCO/IOC
Year: 2016
Subjects: subject: Sargassum
subject: Seaweed
subject: Beach-cast
subject: Macroalgae
subject: Golden tide
subject: Parameter Discipline::Biological oceanography::Macroalgae and seagrass

description: In recent years there have been massive inundations of pelagic Sargassum, known as golden tides, on the beaches of the Caribbean, Gulf of Mexico, andWest Africa, causing considerable damage to the local economy and environment. Commercial exploration of this biomass for food, fuel, and pharmaceutical products could fund clean-up and offset the economic impact of these golden tides. This paper reviews the potential uses and obstacles for exploitation of pelagic Sargassum. Although Sargassum has considerable potential as a source of biochemicals, feed, food, fertiliser, and fuel, variable and undefined composition together with the possible presence of marine pollutants may make golden tides unsuitable for food, nutraceuticals, and pharmaceuticals and limit their use in feed and fertilisers. Discontinuous and unreliable supply of Sargassum also presents considerable challenges. Low-cost methods of preservation such as solar drying and ensiling may address the problem of discontinuity. The use of processes that can handle a variety of biological and waste feedstocks in addition to Sargassum is a solution to unreliable supply, and anaerobic digestion for the production of biogas is one such process. More research is needed to characterise golden tides and identify and develop commercial products and processes.
Supersulfated cements based on volcanic raw materials
Creators: name: Cabrera-Luna, K.
name: Maldonado-Bandala, E. E.
name: Nieves-Mendoza, D.
name: Escalante García, J. I.
Publisher: name: Academic Journal of Civil Engineering
Year: 2017

description: Research efforts worldwide have focused on developing alternative binders that would help to reduce the Greenhouse gas emissions associated to the production of Portland cement. Various raw materials, natural or byproducts, have been studied for the development of several types of binders. One of those greener cements are the so called supersulphated, which are commonly formulated using about 80% blast furnace slag and a source calcium sulphate and an alkaline activator that is commonly clinker of Portland cement. This paper presents results from an investigation on a novel supersulphated-type binder which contains at least 60% volcanic pumice; the sulphatic activators were hemihydrate and waste anhydrite, while the alkaline activator was portland cement (PC). The Taguchi method was used for the experimental design, which included variation in the composition of the binder and curing temperatures within the range of 20 to 60°C; a selection of 4 factors using 2 and 3 levels led to an orthogonal array L18 (21x33). The compressive strength was the response variable. After 28 days, the optimal composition showed 20.16MPa for a paste made of 70%pumice-20%PC-10%Anhydrite cured for 22 h at 60°C then at 20°C. In general, the pastes showed a trend towards higher strengths. The effect of higher curing temperatures and higher PC content were favorable for the strength. The microstructures showed that the pumice reacted although not very actively. Thermal analysis evidenced the formation of C-S-H, ettringite and gypsum. Some of mortars were cured under water and showed strength stability, which further evidenced the formation of C-S-H. A general discussion on the effects of the experimental parameters on strength and reaction products will be discussed.
description: Academic Journal of Civil Engineering, Vol 35 No 2 (2017): Special Issue - ICBBM 2017
Mechanical properties and durability of mortar with rice husk ash calcined at low temperature
Creators: name: Chen, C. T.
name: Chen, P. H.
name: Yen, Y. L.
Publisher: name: Academic Journal of Civil Engineering
Year: 2017

description: In past studies, rice husk ash (RHA) calcined at 1000 °C or higher was found active. They can be alkali-activated or induce pozzolanic reactions in cement hydrates. However, calcination at high temperature consumes much energy. In addition, most RHA is produced at an open-aired site. The burning temperature cannot be so high even in a power plant. In view of these issues, this study explores the mechanical properties and durability of mortar in the presence of RHA produced at low temperature. During the experiments, the rice husk was calcined under different temperature (400-1000 °C). Results showed that the properties of the RHA met the requirements in ASTM C618. Then, the mortar was prepared at w/c of 0.6, the cement in mortar was replaced by RHA by 5%-20% by volume, and the compressive strengths of the mortar were conducted. The 10% was found the optimum. Specimens with RHA calcined under 800 had higher strengths higher than those with RHA calcined at 1000 °C. However, the specimens with RHA calcined at 400 °C had the highest compressive strength at all ages possibly due to high remaining carbon content which absorbed water and reduced the w/c. Further results also showed that the shrinkage did not change significantly with the calcining temperature and dosage of the RHA, but the expansion due to alkali-silica reaction was effectively inhibited at 10%. RHA calcined by 400 °C had the best inhibition on expansion due to alkali-silica reaction (ASR) than that calcined by 800 °C or 1000 °C.
description: Academic Journal of Civil Engineering, Vol 35 No 2 (2017): Special Issue - ICBBM 2017
Variational approach for resolving the flow of generalized Newtonian fluids in circular pipes and plane slits
Creators: name: Sochi, Taha
Publisher: name: figshare
Year: 2015
Subjects: Applied Physics
Mechanics
Computational Physics

description: In this paper, we use a generic and general variational method to obtain solutions to the flow of generalized Newtonian fluids through circular pipes and plane slits. The new method is not based on the use of the Euler-Lagrange variational principle and hence it is totally independent of our previous approach which is based on this principle. Instead, the method applies a very generic and general optimization approach which can be justified by the Dirichlet principle although this is not the only possible theoretical justification. The results that were obtained from the new method using nine types of fluid are in total agreement, within certain restrictions, with the results obtained from the traditional methods of fluid mechanics as well as the results obtained from the previous variational approach. In addition to being a useful method in its own for resolving the flow field in circular pipes and plane slits, the new variational method lends more support to the old variational method as well as for the use of variational principles in general to resolve the flow of generalized Newtonian fluids and obtain all the quantities of the flow field which include shear stress, local viscosity, rate of strain, speed profile and volumetric flow rate. The theoretical basis of the new variational method, which rests on the use of the Dirichlet principle, also provides theoretical support to the former variational method.
Staying With the Party, Switching or Exiting? A Comparative Analysis of Determinants of Party Switching and Abstaining
Creators: name: Dassonneville, Ruth
name: Blais, André
name: Dejaeghere, Yves
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences

description: A large body of literature has investigated the factors that lead to abstention on the one hand or vote volatility on the other hand. We argue in this paper that the most fruitful approach is to simultaneously consider the exit, voice, and loyalty options. The analyses are based on data from the Comparative Study of Electoral Systems and cover a broad set of advanced democracies. We demonstrate that while party switchers and abstainers have a lot in common, switching parties can be considered a more positive choice. Most importantly, contrary to what previous research suggested and in contrast to abstainers, party switchers cannot be characterized as frustrated with politics. Furthermore, the supply side does to a certain extent affect whether voters choose to remain loyal, switch parties, or abstain from voting.
Abeliaside, a new phenolic glucoside from Abelia triflora
Creators: name: Areej Mohammad Al-Taweel
name: Shagufta Perveen
name: Fawzy, Ghada Ahmed
name: Khan, Afsar
name: Mehmood, Rashad
name: Malik, Abdul
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A new phenolic glucoside, abeliaside, along with four known compounds, 5,6,7,4′-tetrahydroxy flavones, caffeic acid, 4-O-caffeoylquinic acid and caffeic acid glucoside, was isolated from the leaves of Abelia triflora R. Br. (Caprifoliaceae). The structure of the new compound was elucidated by different spectroscopic techniques. Compounds 1–5 were assayed for their anticancer activities against two cancerous human cell lines, MCF-7 and PC-3 cells, and normal Vero cell line using the crystal violet staining method. From the results it could be seen that caffeic acid possessed the highest anticancer effect against MCF-7 (IC50: 17 μg/mL) and PC-3 (IC50: 20.1 μg/mL) compared to vinblastine sulphate as reference drug (IC50: 4.6, 2.8 μg/mL). The other compounds showed weak anticancer activity on both cell lines.
Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108
Creators: name: Sasiphimol Sawadsitang
name: Wiyada Mongkolthanaruk
name: Nuttika Suwannasai
name: Sirirath Sodngam
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Xylaria cf. cubensis PK108 was identified by its distinctive morphological characteristics and its internal transcribed spacers sequence analysis. The chromatographic separation and structural elucidation based on spectroscopic analysis of fungal crude extracts led to 10 compounds; tryptoquivaline L (1), fiscalin C (2), epi-fiscalin C (3), cytochalasin D (4), ergosterol (5), ergosterol peroxide (6), chevalone C (7), xylaranol B (8), helvolic acid (9) and cyclo-(l-Pro-l-Leu) (10). The bioassay screening showed that 4 displayed cytotoxicity against KB and NCI-H187 cancer cell lines with IC50 values of 3.25 and 5.95 μg mL− 1. 6 exhibited cytotoxicity against NCI-H187 with an IC50 value of 5.81 μg mL− 1. 7 and 9 showed antimalarial activity with IC50 values of 25.00 and 6.25 μg mL− 1, respectively. This result establishes Xylaria as broad spectrum bioactive compound producers.
title: In-situ formation of solidified hydrogen thin-membrane targets using a pulse tube cryocooler
Creators: name: Astbury, S.
name: Bedacht, S.
name: Brummitt, P.
name: Carroll, D.
name: Clarke, R.
name: Crisp, S.
name: Hernandez-Gomez, C.
name: Holligan, P.
name: Hook, S.
name: Merchan, J. S.
name: Neely, D.
name: Ortner, A.
name: Rathbone, D.
name: Rice, P.
name: Schaumann, G.
name: Scott, G.
name: Spindloe, C.
name: Spurdle, S.
name: Tebartz, A.
name: Tomlinson, S.
name: Wagner, F.
name: Borghesi, M.
name: Roth, M.
name: Tolley, M. K.
Publisher: name: IOP Publishing
Year: 2024

description: An account is given of the Central Laser Facility's work to produce a cryogenic hydrogen targetry system using a pulse tube cryocooler. Due to the increasing demand for low Z thin laser targets, CLF (in collaboration with TUD) have been developing a system which allows the production of solid hydrogen membranes by engineering a design which can achieve this remotely; enabling the gas injection, condensation and solidification of hydrogen without compromising the vacuum of the target chamber. A dynamic sealing mechanism was integrated which allows targets to be grown and then remotely exposed to open vacuum for laser interaction. Further research was conducted on the survivability of the cryogenic targets which concluded that a warm gas effect causes temperature spiking when exposing the solidified hydrogen to the outer vacuum. This effect was shown to be mitigated by improving the pumping capacity of the environment and reducing the minimum temperature obtainable on the target mount. This was achieved by developing a two-stage radiation shield encased with superinsulating blanketing; reducing the base temperature from 14 ± 0.5 K to 7.2 ± 0.2 K about the coldhead as well as improving temperature control stability following the installation of a high-performance temperature controller and sensor apparatus. The system was delivered experimentally and in July 2014 the first laser shots were taken upon hydrogen targets in the Vulcan TAP facility.
Asylum Research AFM Tips and Tricks
Creators: name: Fox, Austin
Publisher: name: figshare
Year: 2015
Subjects: subject: Applied Physics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: Asylum Research AFM Tips and Tricks This document describes some things that have been found to work well or were learned from Asylum Techs.
State of the Art and Potential Future Applications of Metal Organic Frameworks for Metal Ion Recovery
Creators: name: Fernandez de Luis, Roberto
name: Torres, Dimas
name: Sainz, G. Paula
name: Lopes, C
name: Larrea, Edurne S.
name: Fidalgo-Marijuan, Arkaitz
name: Copello, Guilermo
name: Arriortua, María Isabel
Publisher: name: Zenodo
Year: 2020
Subjects: Heavy Metals
Water Pollution
Metal Organic Frameworks

description: Brief descroption of the State of the Art and Potential Future Applications of Metal Organic Frameworks for Metal Ion Recovery
description: Not relevant
Sensitive RDM Project Plan Version 0.1
Creators: name: Blyth, Graham
name: Burnham, Andrew
name: Tedds, Jonathan
name: Turner, Andy
name: Welburn, Steve
Publisher: name: figshare
Year: 2015
Subjects: subject: Digital Humanities
subject: Library and Information Studies
subject: FOS: Media and communications

description: A more detailed project plan. The project plan is a living document that will be updated as the work progresses. The master version of this document is on Google Docs and a link to this is on Figshare. At further key stages the project plan is to be shared on Figshare.
Nicotinamide–Indole Binary Drug System: Thermodynamic and Interfacial Studies
Creators: name: Vishnu Kant
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Biotechnology
Pharmacology
Medicine
Physics
Engineering
Biochemistry
Biophysics

description: Crystal engineering, which can potentially be applied to a wide range of crystalline materials, offer an alternative and potentially fruitful method for improving pharmaceutical properties of drugs. The molecular mobility inherent to amorphous/crystalline phases can lead to molecular associations between different components, such that a single crystalline phase of multiple components is formed. The present investigation measures the solid–liquid equilibria (SLE) of nicotinamide (NA)-indole (IN) binary drug system. The solid–liquid equilibrium phase diagram of NA-IN system was determined by the thaw-melt method in the form of a temperature-composition curve. It shows the formation of a simple eutectic at a 0.953 mole fraction of indole, at 48°C. The excess thermodynamic quantities (gE, hE, and sE) have been estimated by computing heat of fusion data and activity coefficient of the component in a binary mix. These values highlight the ordering, stability, and structure of eutectic and non-eutectic alloys. The thermodynamic mixing functions provide information about the nature of mixing of the components during alloying. The negative value of the integral mixing function, ΔGM for eutectic and some non-eutectic alloys indicates spontaneous mixing. The driving force of nucleation during solidification (ΔGv) and the critical free energy of nucleation (ΔG*) obtained at different undercoolings have also been highlighted. The values of radius of critical nucleus (r*) of alloys lies within the nm scale, which suggests new dimensions of solidification processes for nano solid drug dispersions. The solid–liquid interfacial energy (σ), the grain boundary energy (σgb), and the Gibbs–Thomson coefficient (τ) of the drug alloys have been discussed. Interface morphology of the alloys follows the Jackson's surface roughness (α) theory and predicts that faceted growth (α > 2) proceeds in all cases.Supplemental data for this article can be accessed at www.tandfonline.com/gmcl
Defining the Political Advocacy Activities of Homeless Service Providers: A Qualitative Analysis
Creators: name: Anasti, Theresa
Publisher: name: figshare
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology

description: This is a qualitative study of 11 homeless service nonprofits about their ability to combine their advocacy activities as well as their service priorities. I found that government funding, often thought to inhibit policy advocacy, actually facilitates it. However, policy advocacy as a result of government funding often results in advocacy for social maintenance, rather than social benefits for their marginalized clients.
Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress
Creators: name: Okazaki, Yasumasa
name: Sasaki, Kanako
name: Ito, Nanami
name: Tanaka, Hiromasa
name: Matsumoto, Ken-Ichiro
name: Hori, Masaru
name: Toyokuni, Shinya
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Marine Biology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Non-thermal plasma (NTP) devices have been explored for medical applications. NTP devices discharge electrons, positive ions, ultraviolet (UV), reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as the hydroxyl radical (•OH), singlet oxygen (1O2), superoxide (O2•-), hydrogen peroxide (H2O2), ozone, and nitric oxide, at near-physiological temperature. At preclinical stages or in human clinical trials, NTP promotes blood coagulation, eradication of bacterial, viral, and biofilm-related infections, wound healing, and cancer cell death. Here, we observed that ferric, vanadium, and gold(III) ions significantly elevated lipid peroxidation, which was measured by 2-thiobarbituric acid-reactive substances (TBARS) in combination with NTP exposure. Using 3,3,5,5-tetramethyl-1-pyrroline-N-oxide (M4PO) as a spin probe in electron paramagnetic resonance (EPR), we observed that tetrachloroaurate (III) yielded an M4PO-X spin adduct. Tetrachloroaurate-induced oxidation was attenuated efficiently by reduced (GSH) and oxidized glutathione (GSSG), while glycine (Gly), and L-glutamate (Glu), components of GSH, were ineffective. Furthermore, GSH and GSSG efficiently suppressed tetrachloroaurate-induced lipid peroxidation, while Gly and Glu were ineffective in suppressing TBARS elevation. These results indicate that tetrachloroaurate-induced oxidation is attenuated by GSH as well as GSSG. Further studies are warranted to elucidate the redox reactions between metal ions and biomolecules to advance the clinical application of NTP.
Long-term impacts of unconventional drilling operations on human and animal health
Creators: name: Bamberger, Michelle
name: Oswald, Robert E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Medicine

description: Public health concerns related to the expansion of unconventional oil and gas drilling have sparked intense debate. In 2012, we published case reports of animals and humans affected by nearby drilling operations. Because of the potential for long-term effects of even low doses of environmental toxicants and the cumulative impact of exposures of multiple chemicals by multiple routes of exposure, a longitudinal study of these cases is necessary. Twenty-one cases from five states were followed longitudinally; the follow-up period averaged 25 months. In addition to humans, cases involved food animals, companion animals and wildlife. More than half of all exposures were related to drilling and hydraulic fracturing operations; these decreased slightly over time. More than a third of all exposures were associated with wastewater, processing and production operations; these exposures increased slightly over time. Health impacts decreased for families and animals moving from intensively drilled areas or remaining in areas where drilling activity decreased. In cases of families remaining in the same area and for which drilling activity either remained the same or increased, no change in health impacts was observed. Over the course of the study, the distribution of symptoms was unchanged for humans and companion animals, but in food animals, reproductive problems decreased and both respiratory and growth problems increased. This longitudinal case study illustrates the importance of obtaining detailed epidemiological data on the long-term health effects of multiple chemical exposures and multiple routes of exposure that are characteristic of the environmental impacts of unconventional drilling operations.
Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice
Creators: name: Puri, Gayatri
name: Naura, Amarjit S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Acute lung injury (ALI) caused by acid aspiration often accompanies bacterial components leading to exaggerated inflammation and can result in acute respiratory distress syndrome (ARDS), but the underlying mechanisms behind such an exacerbation remain unclear. NLRP3 inflammasome and mitochondrial ROS (mtROS) have been implicated in ALI but its role in injury caused through two hit i.e. Hydrochloric acid (HCl) + Lipopolysaccharide (LPS) is not known. Therefore, the present study is designed to elucidate the role of mtROS-NLPR3 inflammasome upon “two-hit” mediated ALI. Our data showed that “two-hit” induced ALI results in aggravated lung inflammation as compared to either of single hit(s) as reflected by a steep increase in inflammatory cells particularly neutrophils in bronchoalveolar lavage fluid (BALF). Further, enhanced inflammation was associated with increased mtROS as depicted by data on mean fluorescence intensity (MFI) of MitoSOX+ neutrophils and macrophages in BALF of two-hit simulated mice. Importantly, ALI results in activation of NLRP3 inflammasome as reflected by active caspase-1 protein expression and IL-1β levels. Interestingly, NLRP3 inflammasome inhibitor, MCC950 suppressed the lung inflammation remarkably. Further, Mito-tempo, a mitochondrial-targeted antioxidant, halted “two-hit” mediated NLRP3 inflammasome activation and IL-1β release followed by amelioration of lung inflammation. Suppression in MFI of MitoSOX+ stained neutrophils and macrophages by Mito-tempo was associated with down-regulation of phospho-p65-NF-κB and its dependent genes (IL-1β/TNF-α/IL-6). Overall, our data suggest that NLRP3 inflammasome activation by mtROS plays a critical role in pathogenesis of exaggerated inflammation and therefore targeting mtROS-NLRP3 inflammasome axis may be an attractive option for combating ALI/ARDS.
Molecular analysis of some camel cytochrome P450 enzymes reveals lower evolution and drug-binding properties
Creators: name: Kandeel, Mahmoud
name: Altaher, Yousef
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Pharmacology
subject: Genetics
subject: Microbiology
subject: Biochemistry

description: Camels bear unique genotypes and phenotypes for adaptation of their harsh environment. They have unique visual systems, sniffing, water metabolism, and heat-control mechanisms that are different from other creatures. The recent announcement for the complete sequence of camel genome will allow for the discovery of many secrets of camel life. In this context, the genetic bases of camel drug-metabolizing enzymes are still unknown. Furthermore, the genomic content of camel that rendered it highly susceptible to some drugs (as monensin and salinomycin) and became easily intoxicated needs to be investigated. The objectives of this work are the annotation of camel genome and retrieval of camel for cytochrome P450 (CYP) 1A1, 2C, and 3A enzymes. This is followed by comprehensive phylogenetic, evolution, molecular modeling, and docking studies. In comparison with the human enzymes, camel CYPs showed lower evolution rate, especially CYP1A1. Furthermore, the binding of monensin, salinomycin, alfa-naphthoflavone, felodepine, and ritonavir was weaker in camel enzymes. Interestingly, rerank score indicated instable binding of monensin and salinomycin with camel CYP1A1 as well as salinomycin with camel CYP2C. The results of this work suggest that camels are more susceptible to toxicity with compounds undergoing metabolic oxidation. This conclusion was based on lower evolution rate and lower binding potency of camels compared with the human enzymes.
title: Elektromobilność w Europie - perspektywy jej wdrożenia w Polsce
Creators: name: Dereń, Klaudia
name: Owczarek, Weronika
Publisher: name: Publishing House of Poznan University of Technology
Year: 2021

description: Zeszyty Naukowe Politechniki Poznańskiej. Organizacja i Zarządzanie, 84, 19-30
Green and gentle synthesis of Cu2O nanoparticles using lignin as reducing and capping reagent with antibacterial properties
Creators: name: Peipei Li
name: Lv, Wei
name: Shiyun Ai
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Engineering

description: In this work, Cu2O nanoparticles of a particular shape were prepared by an eco-friendly, gentle and low-cost synthetic method using lignin as a reducing and capping reagent. Structure and morphology of the Cu2O nanoparticles were characterised by high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction (XRD) and Fourier-transform (FT-IR) spectroscopy. The results established that Cu2O nanoparticles coated by lignin showed a particular shape. The morphology of Cu2O nanoparticles presented as some loose accumulation of particles just like broccoli, and the particle size range was between 100 and 200 nm. And, the XRD revealed the structure of crystalline of the Cu2O nanoparticles. In addition, the sterilisation of Cu2O nanoparticles on Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was also investigated. The Cu2O nanoparticles showed effective bactericidal activity against E. coli and S. aureus. The antibacterial rate could get 100% after 30 min with 4.0 g/L Cu2O nanoparticles. Furthermore, the Cu2O nanoparticles were confirmed to have low cytotoxicity.
Evaluation of phase stability and diffusion kinetics in novel BCC-structured high entropy alloys
Creators: name: Zajusz, Marek
name: Jawańska, Monika
name: Dąbrowa, Juliusz
name: Berent, Katarzyna
name: Cieślak, Grzegorz
name: Kulik, Tadeusz
name: Mroczka, Krzysztof
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The diffusion kinetics of the BCC-structured high-entropy alloys (HEAs) is studied experimentally for the first time. First, the literature data regarding the transition-metal based, single-phase, BCC-structured HEAs is re-evaluated using the state-of-the-art, HEAs-dedicated TCHEA4 thermodynamic database, signalizing the need for further reassessment of the literature data accumulated during the last decade. The selected Al-Cr-Fe-Mn-V system was used for the interdiffusion experiments. The concentration profiles were evaluated using the numerical combinatorial approach, revealing surprisingly fast diffusion kinetics. The comparison with the available diffusion data for conventional BCC alloys supports recent findings regarding the lack of the ‘sluggish diffusion’ in HEAs. IMPACT STATEMENT The first-ever experimental study of interdiffusion in BCC-structured high-entropy alloys is conducted, revealing fast diffusion kinetics and providing a further argument against the presence of sluggish diffusion effect in HEAs.
Why Males ≠ Corvettes, Females ≠ Volvos, and Scientific Criticism ≠ Ideology: A Response to “Equal ≠ The Same: Sex Differences in the Human Brain”
Creators: name: Fine, Cordelia
name: Joel, Daphna
name: Jordan-Young, Rebecca
name: Anelis Kaiser
name: Rippon, Gina
Publisher: name: figshare
Year: 2015
Subjects: Behavioral Neuroscience

description: In the recent Cerebrum article Equal ≠ the same: Sex differences in the human brain, Larry Cahill offers his perspective on the nature of sex differences in brain and behavior, and what he considers to be a “counter-reaction” to such research by “anti-sex difference” investigators operating from the “deeply ingrained, implicit, false assumption that if men and women are equal, then men and women must be the same.”[1] We welcome this opportunity to correct some of the misapprehensions and mischaracterisations in this account, and present a more nuanced view of the relations among sex, brain and gender.
title: The Role of Public Money in the Digital Age
Creators: name: Rivadeneyra, Francisco
name: Hendry, Scott
name: García, Alejandro
Publisher: name: Bank of Canada
publisherIdentifier: https://ror.org/05cc98565
publisherIdentifierScheme: ROR
Year: 2024

description: A well-functioning monetary system is characterized by public and private forms of money that exchange at par as value flows freely between them. This is essential for efficient transacting and contracting in a market economy. A relevant retail public money—whether in the form of cash, a central bank digital currency or both—is a necessary component of such a monetary system. Some of the other necessary components include financial regulation, deposit insurance, a monetary policy framework and lender of last resort facilities. A monetary system without retail public money would be prone to fragmentation, where different types of private money do not trade at par, and to market failures arising from the network effects of payment platforms.
description: Un système monétaire qui fonctionne bien est caractérisé par des formes de monnaie publique et de monnaies privées qui s’échangent à parité, la valeur pouvant circuler librement entre ces formes de monnaie. Cette parité est essentielle pour faire des transactions et négocier des contrats de manière efficiente dans une économie de marché. Une monnaie publique de détail adéquate – qu’il s’agisse d’argent comptant ou de monnaie numérique de banque centrale, ou des deux – est un élément fondamental d’un système monétaire efficace, tout comme la réglementation financière, l’assurance-dépôts, un cadre de politique monétaire et les mécanismes de prêt de dernier ressort, notamment. En l’absence d’une monnaie publique de détail, un système monétaire serait sujet à la fragmentation – c’est-à-dire il n’y aurait pas de parité de change entre les diverses monnaies privées dans ce système – et à des défaillances du marché provenant des effets de réseau des plateformes de paiement.
Year-round activity patterns in a hyperdiverse community of rainforest amphibians in Madagascar
Creators: name: Janosch Heinermann
name: Rodríguez, Ariel
name: Segev, Ori
name: Edmonds, Devin
name: Dolch, Rainer
name: Vences, Miguel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences

description: Madagascar hosts a high diversity of amphibians estimated at over 500 species, nearly all of them endemic. Surprisingly few data are available on the activity cycles of this fauna, despite its importance for ecological, evolutionary and conservation research. Here we report the results of a year-round survey of amphibians along a transect bordering the Analamazaotra forest near Andasibe in central eastern Madagascar. During 120 transect walks evenly spaced through the year, a total of 2530 individuals of 40 species of anurans was observed. Abundance was higher during the warm/rainy season (December to April) and peaked in February. Of the five climatic predictors measured, only mean temperature and relative humidity showed high importance values, and multi-model averages indicate that these two variables have a strong effect on amphibian abundance along the transect. Species richness showed no evident peak during the study period and was best explained by a model including average temperature and rainfall. Canonical correspondence analysis indicates that Boophis sibilans, B. tephraeomystax, B. boehmei and Plethodontohyla notosticta were more frequently encountered along the transect on cold and humid days while Plethodontohyla mihanika, Gephyromantis boulengeri and Spinomantis aglavei were distinctly more abundant on cold and dry days, and Paradoxophyla palmata on warm and dry days. The results of our study flag a number of species as suitable candidates for future monitoring initiatives and suggest that a simple combination of visual and acoustic surveys can estimate amphibian activity with high sample sizes in Madagascar’s rainforests.