cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
AARP Financial Security Trends Survey: January 2022 (Wave 1)
Creators: name: AARP
Publisher: name: Roper Center for Public Opinion Research
Year: 2025

description: Current employment (9); pre/post-coronavirus (COVID-19) financial situation (3); reasons for changes in financial situation (30); expect improvement/worsening of financial situation in the next year (1); concern about covering expenses (7); debt (73); retirement savings (44); work/life balance (1); good employment opportunities (1); financial fraud (1); inflation (1); level of threat from lost income/unexpected cost (2); emergency savings (21); financial emergencies over the last 12 months (45); non-emergency use of emergency savings (18); monthly expenses compared to last year (12); largest monthly expenses (2); online financial planning/budgeting tools (2); major life events in the last year (15); family caregiver (1); financial support to adult family member/relative (1); financial impacts of criminal record (5); financial assets/accounts (9).
BMSC–HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression
Creators: name: Eichberger, Jonas
name: Froschhammer, Daniel
name: Schulz, Daniela
name: Scholz, Konstantin J.
name: Federlin, Marianne
name: Ebensberger, Helga
name: Reichert, Torsten E.
name: Ettl, Tobias
name: Bauer, Richard J.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: head and neck cancer; bone marrow-derived stromal cells; collagenase enzymes; MMP-1; MMP-9
subject: 610 Medizin

description: In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone marrow-derived MSCs (BMSCs) and head and neck cancer (HNC) cells. This interaction was found to activate specific markers, notably the osteogenic marker alkaline phosphatase and the oncogene Runx2. These activations corresponded with the release of collagenase enzymes, MMP9 and MMP2. To gain insights into bone resorption related to this interaction, bovine bone slices were used, supporting the growth of “heterogeneous spheroids” that contained both BMSCs and HNC cells. Through scanning electron microscopy and energy-dispersive X-ray (EDX) analysis, it was observed that these mixed spheroids were linked to a notable increase in bone degradation and collagen fiber exposure, more so than spheroids of just BMSCs or HNC cells. Furthermore, the EDX results highlighted increased nitrogen content on bone surfaces with these mixed clusters. Overall, the findings underscore the significant role of BMSCs in tumor growth, emphasizing the need for further exploration in potential cancer treatment strategies.
The microbial metabolite desaminotyrosine enhances T-cell priming and cancer immunotherapy with immune checkpoint inhibitors
Creators: name: Joachim, Laura
name: Göttert, Sascha
name: Sax, Anna
name: Steiger, Katja
name: Neuhaus, Klaus
name: Heinrich, Paul
name: Fan, Kaiji
name: Orberg, Erik Thiele
name: Kleigrewe, Karin
name: Ruland, Jürgen
name: Bassermann, Florian
name: Herr, Wolfgang
name: Posch, Christian
name: Heidegger, Simon
name: Poeck, Hendrik
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Desaminotyrosine Melanoma Immune checkpoint inhibitors Gut microbiome Microbial metabolites Antibiotics
subject: 610 Medizin

description: Background

Inter-individual differences in response to immune checkpoint inhibitors (ICI) remain a major challenge in cancer treatment. The composition of the gut microbiome has been associated with differential ICI outcome, but the underlying molecular mechanisms remain unclear, and therapeutic modulation challenging.
Methods

We established an in vivo model to treat C57Bl/6j mice with the type-I interferon (IFN-I)-modulating, bacterial-derived metabolite desaminotyrosine (DAT) to improve ICI therapy. Broad spectrum antibiotics were used to mimic gut microbial dysbiosis and associated ICI resistance. We utilized genetic mouse models to address the role of host IFN-I in DAT-modulated antitumour immunity. Changes in gut microbiota were assessed using 16S-rRNA sequencing analyses.
Findings

We found that oral supplementation of mice with the microbial metabolite DAT delays tumour growth and promotes ICI immunotherapy with anti-CTLA-4 or anti-PD-1. DAT-enhanced antitumour immunity was associated with more activated T cells and natural killer cells in the tumour microenvironment and was dependent on host IFN-I signalling. Consistent with this, DAT potently enhanced expansion of antigen-specific T cells following vaccination with an IFN-I-inducing adjuvant. DAT supplementation in mice compensated for the negative effects of broad-spectrum antibiotic-induced dysbiosis on anti-CTLA-4-mediated antitumour immunity. Oral administration of DAT altered the gut microbial composition in mice with increased abundance of bacterial taxa that are associated with beneficial response to ICI immunotherapy.
Interpretation

We introduce the therapeutic use of an IFN-I-modulating bacterial-derived metabolite to overcome resistance to ICI. This approach is a promising strategy particularly for patients with a history of broad-spectrum antibiotic use and associated loss of gut microbial diversity.
[Discours]
[Discours]
Creators: name: Ar Fusteg, Yann (1855-1910)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Relation: https://bibnumcrbc.huma-num.fr/document/5289
description: 0001.jpg
description: 0002.jpg
Chinchillula sahamae Thomas 1898
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Chinchillula
Chinchillula sahamae

description: Chinchillula sahamae Thomas 1898
Chinchillula sahamae Thomas 1898, Ann. Mag. Nat. Hist., ser. 7, 1: 280.
Type Locality: Bolivia, La Paz Dept., 50 km N Mt Sajama, Esperanza, Pacajes, 4200 m.
Vernacular Names: Achallo.
Distribution: Altiplano region of S Perú, W Bolivia (above 4000 m), and N Chile.
Conservation: IUCN – Lower Risk (lc).
Discussion: The presence of this species in NW Argentina, as reported in many faunal works and checklists (Cabrera, 1961; Díaz, 2000; Musser and Carleton, 1993), is not based on confirmed identification of any vouchered specimen (see Galliari et al., 1996; Ortiz et al., 2000 a).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1111, DOI: 10.5281/zenodo.7316535
From bench to bedside – current clinical and translational challenges in fibula free flap reconstruction
Creators: name: Baecher, Helena
name: Hoch, Cosima C.
name: Knoedler, Samuel
name: Maheta, Bhagvat J.
name: Kauke-Navarro, Martin
name: Safi, Ali-Farid
name: Alfertshofer, Michael
name: Knoedler, Leonard
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: fibula free flap, mandibular reconstruction, artificial intelligence, 3D printing, computer-aided design, CAM, bioprinting
subject: 610 Medizin

description: Fibula free flaps (FFF) represent a working horse for different reconstructive scenarios in facial surgery. While FFF were initially established for mandible reconstruction, advancements in planning for microsurgical techniques have paved the way toward a broader spectrum of indications, including maxillary defects. Essential factors to improve patient outcomes following FFF include minimal donor site morbidity, adequate bone length, and dual blood supply. Yet, persisting clinical and translational challenges hamper the effectiveness of FFF. In the preoperative phase, virtual surgical planning and artificial intelligence tools carry untapped potential, while the intraoperative role of individualized surgical templates and bioprinted prostheses remains to be summarized. Further, the integration of novel flap monitoring technologies into postoperative patient management has been subject to translational and clinical research efforts. Overall, there is a paucity of studies condensing the body of knowledge on emerging technologies and techniques in FFF surgery. Herein, we aim to review current challenges and solution possibilities in FFF. This line of research may serve as a pocket guide on cutting-edge developments and facilitate future targeted research in FFF.
Criconematidae Taylor 1936
Creators: name: Gusakov, Vladimir A.
name: Gagarin, Vladimir G.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Nematoda
Secernentea
Tylenchida
Criconematidae

description: Family Criconematidae Taylor, 1936
123. Criconematidae gen. sp.— {55} (0, 0, 8, 0; 1)
Population structure and abundance. 7 females (3x10 3/m2).
Ecology and distribution. Criconematides are soil nematodes; some of the species are plant ectoparasites (Andrássy 2007). As a rule occur in water bodies accidentally.
Remarks. Several species of various genera are known from Vietnam (Nguyen & Nguyen 2005; Nguyen 2007). We failed to identify the specimens we sampled.
description: Published as part of Gusakov, Vladimir A. & Gagarin, Vladimir G., 2017, An annotated checklist of the main representatives of meiobenthos from inland water bodies of Central and Southern Vietnam. I. Roundworms (Nematoda), pp. 1-43 in Zootaxa 4300 (1) on page 34, DOI: 10.11646/zootaxa.4300.1.1, http://zenodo.org/record/837117
Bussmann, Claus und Sluis, Douwe van der: Die Bibel studieren
Creators: name: Heinemann, F.K.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Anastoechus macrophthalmus Bezzi 1921
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Anastoechus
Anastoechus macrophthalmus

description: Anastoechus macrophthalmus Bezzi, 1921
20. Anastoechus macrophthalmus 1ɗ South Africa (Eastern Cape): Willowmore, 25.xi.1906 (H. Brauns). MS page 13.
Bezzi, 1921a: 47, 52 – key and diagnosis; 1ɗ, South Africa (Western Cape): Hex River, xii.1884 (L. Péringuey) (SAMC).
Bezzi, 1922: 74 – mentioned its presence in his (1921a) key and in his anticipated Hungarian paper; specimens of both sexes ex Willowmore, xi and ii (in HNHM and Bezzi’s collection). MSNM has two syntypes from Willowmore: 1ɗ, xi.1912 (Dr Brauns); 1Ψ, 28.ii.1915 (Dr Brauns). These specimens also bear small brown labels ‘42 Bezzi’ and ‘44 Bez’ respectively. The Brauns collection in NMSA has 3ɗɗ and 3ΨΨ collected on 25.xi.1912, 1ɗ also has a ’42 Bezzi’ label and 1Ψ collected on 15.xii.1919 with a ‘Bezzi 44’ label. These specimens are considered to be duplicates retained by Dr Brauns and if this is so are not syntypes.
Hesse, 1938: 361 – description from the Hex River specimen and many others in SAMC and BMNH.
Evenhuis & Greathead, 1999: 86 – listed the holotype (destroyed) in HNHM.
Types: Bezzi (1921a) stated that the “ Type ” was in the Hungarian Museum. This is enough to consider it as the holotype. The other specimens listed by Bezzi (1921a, 1922) are paratypes. The holotype was destroyed in the 1956 uprising.
Remarks: Bezzi (1921a) diagnosed A. macrophthalmus by giving comments on a few characters that distinguished it from A. erinaceus Bezzi (thus effectively validating the name). It is a common and widespread species in the karoo biomes of South Africa.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 20, DOI: 10.5281/zenodo.158466
Tracheoesophageal Fistula Closure in a Pediatric Patient Using a Supraclavicular Artery Island Flap
Creators: name: Seebauer, Caroline T.
name: Völkl, Melanie
name: Kunkel, Jürgen
name: Künzel, Julian
name: Kühnel, Thomas
name: Hofmann, Hans-Stefan
name: Bohr, Christopher
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Acquired tracheoesophageal fistulas can lead to large defects with fatal complications. Surgical management is challenging but necessary to prevent respiratory infections and poor weight gain. Therefore, a reliable and pliable flap like the pedicled supraclavicular artery island flap with its wide arc of rotation and robust vascularization is needed for reconstruction. We highlight the surgical technique and postoperative measures in managing a tracheoesophageal fistula due to button battery ingestion in a 9-month-old boy with the supraclavicular artery island flap. In summary, the supraclavicular artery island flap is a safe and successful tool for closure of large acquired tracheoesophageal fistulas in pediatric patients.
Impact of Traumatic Brain Injury on Epileptogenesis and Neuropsychiatric Disorders
Creators: name: ZULAZMI, NURUL ATIQAH
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 520202
subject: Behavioural neuroscience
classificationCode: 520203
subject: Cognitive neuroscience

description: When someone experiences a traumatic brain injury (TBI), it can cause lasting debilitating effects on their psychiatric and behavior, and may lead to conditions like epilepsy. This thesis highlights the use and potential of zebrafish as a model of TBI that has translation capabilities that can be utilized for future therapeutic studies. Our study revealed specific inflammation markers in the zebrafish that relates to the TBI-associated changes in the brain and the development of epilepsy, psychiatric and behavioral disorders post-injury.
Paleographical analysis of letter O
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: Morphological study on the letter O (and some pages about the letter P): collection of samples from inscriptions and papyri, and analysis of paleographical aspects. - Collection of photos ("Grenier").
description: vue 100
description: Source: 4MAR_2_1.3.2-5
description: created: n. d.
Delomys Thomas 1917
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Delomys

description: Delomys Thomas 1917
Delomys Thomas 1917, Ann. Mag. Nat. Hist., ser. 8, 20: 196.
Type Species: Hesperomys dorsalis Hensel 1873
Species and subspecies: 3 species:
Species Delomys collinus Thomas 1917
Species Delomys dorsalis (Hensel 1873)
Species Delomys sublineatus (Thomas 1903)
Discussion: Sigmodontinae incertae sedis. Delomys has variously stood as a genus (Avila-Pires, 1960 c; Gyldenstolpe, 1932; Tate, 1932 f) or merged under Thomasomys, with or without subgeneric division (Ellerman, 1941; Moojen, 1952; Osgood, 1933 d). As remarked by Osgood (1933 d), Thomas in part created Delomys to taxonomically underscore the geographic disjunction between thomasomyines in SE Brazil and the diverse radiation of typical Thomasomys in the N Andes (e.g., see Reig, 1986). Defining morphological traits consolidated and contrasted with types species of Thomasomys and Oryzomys by Voss (1993); chromosomal variation reported by Zanchin et al. (1992 b) and Bonvicino and Geise (1995). While the morphological differentiation of Delomys is comparable to that of other sigmodontine genera, its cladistic stature with regard to Andean thomasomyines—and that of other SE Brazilian endemics like Juliomys, Rhagomys, Phaenomys, and Wilfredomys (oryzomyine-thomasomyine plesions sensu Voss, 1993)—must await broader-based phylogenetic inquiry. In one such preliminary view using cytochrome b sequence data, Delomys erratically formed a basal clade with various other tribes depending upon the analysis (Smith and Patton, 1999); those authors arranged the genus as one of several "additional unique lines."
Number of recognized species given as four (Moojen, 1952), three (Bonvicino and Geise, 1995; Reig, 1986), two (Ellerman, 1941; Gyldenstolpe, 1932; Hershkovitz, 1998; Voss, 1993), or one (Cabrera, 1961; Corbet and Hill, 1991; Honacki et al., 1982). The three recognized here integrates the revision of Voss (1993) and karyological results of Zanchin et al. (1992 b) and Bonvicino et al. (1995). Avila-Pires (1960 c) associated Calomys plebejus Winge, 1887, as another form of Delomys; Voss (1993) accepted the generic assignment but regarded plebejus as a nomen dubium, considering its equivalence to any of the living species as indeterminate.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1111, DOI: 10.5281/zenodo.7316535
Anorexia nervosa during COVID-19: loss of personal control and alexithymia as important contributors to symptomatology in adolescent girls
Creators: name: Jarvers, Irina
name: Ecker, Angelika
name: Schleicher, Daniel
name: Kandsperger, Stephanie
name: Otto, Alexandra
name: Brunner, Romuald
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Adolescence, COVID-19, Alexithymia, Loss of control, Social media, Anorexia nervosa
subject: 610 Medizin

description: Background

In the course of the COVID-19 pandemic, a steady increase in adolescent anorexia nervosa admissions has been observed. Contributing factors may have been uncontrollable changes in school attendance due to lockdowns and social restrictions. However, patients’ reports on the impact of these factors have not been assessed in detail as of yet. Furthermore, alexithymia, the difficulty to identify and describe one’s own emotions, has increased during the pandemic and is known to be heightened in eating disorders. Thus, it may have contributed to symptom severity in anorexia nervosa during the pandemic.
Methods

The present study examined pandemic-related changes in social media use, body satisfaction, and perceived loss of control and their impact on depressive, anxious, and eating disorder symptomatology in a sample of adolescent girls with anorexia nervosa (n = 29) and healthy controls (n = 23). Additionally, the influence of current alexithymia as a cross-diagnostic risk factor was assessed. Adolescents answered questionnaires once shortly after admission to inpatient, outpatient, or daycare treatment.
Results

An increase in perceived loss of control during the pandemic and heightened alexithymia explained a significant portion of variance in present depressive symptomatology, which in turn contributed to eating disorder symptomatology.
Conclusions

These relationships emphasize alexithymia and perceived loss of control as valuable constructs for early screenings and interventions.
title: Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia
Creators: name: Wang, Chenglong
name: Stöckl, Sabine
name: Pattappa, Girish
name: Schulz, Daniela
name: Hofmann, Korbinian
name: Ilic, Jovana
name: Reinders, Yvonne
name: Bauer, Richard J.
name: Sickmann, Albert
name: Grässel, Susanne
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: extracellular vesicles; BMSC; osteogenic differentiation; hypoxia; normoxia; ROS; antioxidants
subject: 610 Medizin

description: In orthopedics, musculoskeletal disorders, i.e., non-union of bone fractures or osteoporosis, can have common histories and symptoms related to pathological hypoxic conditions induced by aging, trauma or metabolic disorders. Here, we observed that hypoxic conditions (2% O2) suppressed the osteogenic differentiation of human bone marrow-derived mesenchymal cells (hBMSC) in vitro and simultaneously increased reactive oxygen species (ROS) production. We assumed that cellular origin and cargo of extracellular vesicles (EVs) affect the osteogenic differentiation capacity of hBMSCs cultured under different oxygen pressures. Proteomic analysis revealed that EVs isolated from osteogenic differentiated hBMSC cultured under hypoxia (hypo-osteo EVs) or under normoxia (norm-osteo EVs) contained distinct protein profiles. Extracellular matrix (ECM) components, antioxidants and pro-osteogenic proteins were decreased in hypo-osteo EVs. The proteomic analysis in our previous study revealed that under normoxic culture conditions, pro-osteogenic proteins and ECM components have higher concentrations in norm-osteo EVs than in EVs derived from naïve hBMSCs (norm-naïve EVs). When selected for further analysis, five anti-hypoxic proteins were significantly upregulated (response to hypoxia) in norm-osteo EVs. Three of them are characterized as antioxidant proteins. We performed qRT-PCR to verify the corresponding gene expression levels in the norm-osteo EVs’ and norm-naïve EVs’ parent cells cultured under normoxia. Moreover, we observed that norm-osteo EVs rescued the osteogenic ability of naïve hBMSCs cultured under hypoxia and reduced hypoxia-induced elevation of ROS production in osteogenic differentiated hBMSCs, presumably by inducing expression of anti-hypoxic/ antioxidant and pro-osteogenic genes.
Delomys collinus Thomas 1917
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Delomys
Delomys collinus

description: Delomys collinus Thomas 1917
Delomys collinus Thomas 1917, Ann. Mag. Nat. Hist., ser. 8, 20: 197.
Type Locality: Brazil, Rio de Janeiro State, Itatiaya, 4800 ft (1463 m).
Vernacular Names: Montane Delomys.
Distribution: Middle to upper elevations, 1000-2700 m, in disjunct mountain ranges (E Minas Gerais, Espírito Santo and Rio de Janeiro), SE Brazil.
Discussion: Voss (1993) noted the usual absence of pectoral mammae in this form, but absent clear mensural differentiation, elected to retain it under D. dorsalis, perhaps as a subspecies as originally placed by Thomas (1917 c); whereas, Bonvicino and Geise (1995) obtained different fundamental numbers from collinus samples compared with those of D. dorsalis (2n = 82 in both) and recommended specific recognition. The concordance of these independent traits, and others, should be verified with larger samples as a basis for reinforcing their status as distinct species.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1112, DOI: 10.5281/zenodo.7316535
Australoechus capensis Linnaeus 1767
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Australoechus
Australoechus capensis

description: Australoechus capensis (Linnaeus, 1767)
(Fig. 9)
18. Bombylius braunsi 1ɗ1Ψ South Africa (Eastern Cape): Willowmore, viii.1906 (H. Brauns). MS page 8.
Bezzi, 1921a: 23, 27 – key and short description; referred to species being found ‘near Willowmore (Cape) by Dr Brauns’ and to be described in his forthcoming paper on the Bombyliidae in the Hungarian Museum.
Bezzi, 1922: 72 – referred to key in Bezzi (1921a) and intention to describe in his Hungarian National Museum paper. ‘Exempliaria nonnulla e Willowmore, Aug. et Sept., in Museo Budapestini et in collectione mea’. Bezzi’s collection in MSNM contains a single female from Willowmore, 4.ix.1919 (Dr Brauns) with a separate red label ‘20’.
Bezzi, 1924: 47 – key only.
Hesse, 1938: 246 – described from females from Brauns’s collection: Willowmore, viii.1921; ix.1921; viii.1925.
Hesse, 1961: 83 – synonymised with Bombylius capensis.
Greathead, 1995: 62 – transferred Bombylius capensis to Australoechus.
Evenhuis & Greathead, 1999: 92 – listed (incorrectly) a holotype in SAMC.
Types: The two syntypes in HNHM were destroyed in 1956. The single female syntype in MSNM is here designated lectotype (Fig. 9).
Remarks: The synonymy of A. braunsi with A. capensis is accepted. As recognised by Hesse (1961) A. capensis is a very variable species with respect to the presence, size, and number of dark spots at the wing margin. The lectotype in MSNM runs to capensis in Hesse’s (1938) key.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 20, DOI: 10.5281/zenodo.158466
Delomys dorsalis
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Delomys
Delomys dorsalis

description: Delomys dorsalis (Hensel 1873)
[Hesperomys] dorsalis Hensel 1873, Abh. K. Akad. Wiss. Berlin, 1872: 42.
Type Locality: Brazil, Rio Grande do Sul State, Taquara (as restricted by Avila-Pires, 1994:372).
Vernacular Names: Striped Delomys.
Synonyms: Delomys lechei (Trouessart 1904); Delomys obscura (Leche 1886).
Distribution: Atlantic Forest region of SE Brazil (Minas Gerais and Espírito Santo to Rio Grande do Sul) and NE Argentina (Misiones).
Conservation: IUCN – Lower Risk (lc).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1112, DOI: 10.5281/zenodo.7316535
Hervé Latapie, Jacques Leibowitch, "Intermittences des traitements ICCARRE : Pourquoi si peu d’empressement de la part des grands spécialistes français de la lutte contre le sida ?"
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: 1 fichier
Delomys sublineatus
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Delomys
Delomys sublineatus

description: Delomys sublineatus (Thomas 1903)
[Oryzomys] sublineatus Thomas 1903, Ann. Mag. Nat. Hist., ser. 7, 12: 240.
Type Locality: Brazil, Espírto Santo State, Engenheiro Reeve (= Rive), 500 m.
Vernacular Names: Pallid Delomys.
Distribution: Atlantic Forest region of SE Brazil (Minas Gerais and Espírito Santo to Santa Catarina).
Conservation: IUCN – Lower Risk (lc).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1112, DOI: 10.5281/zenodo.7316535
Tricholepidion gertschi Wygodzinsky 1961
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Zygentoma
Lepidotrichidae
Tricholepidion
Tricholepidion gertschi

description: Tricholepidion gertschi
“Relic Silverfish”
Figures 12 (lateral), 13 (dorsal, ventral)
Plates 4 (lateral), 5 (dorsal, ventral)
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
Obesity Correlates with Chronic Inflammation of the Innate Immune System in Preeclampsia and HELLP Syndrome during Pregnancy
Creators: name: Rimboeck, Julia
name: Gruber, Michael
name: Weigl, Marco
name: Huber, Pia
name: Lunz, Dirk
name: Petermichl, Walter
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: HELLP; preeclampsia; HDP; pregnancy; obesity; PMNs; neutrophils; ROS; NETosis
subject: 610 Medizin

description: HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and a low platelet count and poses an increased risk to the pregnant woman and the unborn child. Individual risk factors such as obesity may alter immunocompetence and influence the course of preeclampsia (PE) or HELLP syndrome. Blood samples were collected from 21 pregnant women (7 healthy, 6 with PE, and 8 with HELLP syndrome) and polymorphonuclear neutrophils (PMNs) were subsequently isolated. Production of radical oxygen species (ROS), cell movement, and NETosis were assessed by live-cell imaging. Surface protein expression and oxidative burst were analyzed by flow cytometry. PE and HELLP patients had significantly higher BMI compared to the healthy control group. Depending on the expression of CD11b, CD62L, and CD66b on PMNs, a surface protein activation sum scale (SPASS) was calculated. PMNs from patients with high SPASS values showed prolonged and more targeted migration with delayed ROS production and NETosis. Obesity is associated with a chronic inflammatory state, which in combination with immunological triggers during pregnancy could modulate PMN functions. Pregnant women with higher BMI tend to have higher SPASS values, indicating activation of the innate immune system that could co-trigger PE or HELLP syndrome.
title: Activité du port de Saint-Malo – 1725 – Saint-Valéry-sur-Somme
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits manufacturés
subject: produits agroalimentaires
subject: graines

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1725 avec le port "Saint-Valéry-sur-Somme"
description: Marchandises au départ de Saint-Malo : huile ; savon
description: Catégories de marchandises au départ de Saint-Malo : produits manufacturés
description: Marchandises arrivées à Saint-Malo : houblon
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; graines
description: Coverage: Grand cabotage
description: Bibliographic citation: LE DOUR, P. Le Commerce maritime de Saint-Malo en 1725 et 1726. DES : Histoire : Rennes 2 : s.d. (Bibliothèque François-Lebrun, MH 1025)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Bombylella auricoma Bezzi 1924
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Bombylella
Bombylella auricoma

description: Bombylella auricoma (Bezzi, 1924)
(Fig. 10)
5. Bombylius auricomus ɗɗΨΨ Ethiopia: Hurso iii. 1911 (Kovács); Jerer Shet’ vi. 1911 (Kovács). MS page 3.
Bezzi, 1924: 44 – key and diagnosis; listed specimens: 2 specimens [only 1ɗ remaining], ‘S Abyssinia’ (R.J. Stordy) in poor condition. Malawi: 2ɗ, Mt Mlange, 26.xi.1912 & 1.i.1913 (S.A. Neave); [1ɗ], Florence Bay, 1.xi.1909 (J.B. Davey). South Africa (Kwa­ Zulu­Natal): [1ɗ], Durban (J.P. Cragoe) (BMNH).
Greathead, 1995: 56 – transferred Bombylius auricomus to Bombylella.
Greathead, 1999: 1007 – key and diagnosis based on the syntypes from ‘S Abyssinia’ and Malawi in BMNH and other specimens from Ethiopia, Kenya, Malawi, and Uganda.
Evenhuis & Greathead, 1999: 100 – 5 syntypes located in BMNH; an indeterminate number of syntypes in MSNM noted as lost.
Types: The syntypes in HNHM were destroyed in 1956 and those in MSNM are lost, leaving only the six syntypes (not five as stated in Evenhuis & Greathead, 1999) in BMNH. Of these, the specimen in best condition is the male from Mt Mlange, 1.i.1913, which is here designated lectotype (Fig. 10).
Remarks: The status of B. auricoma is not in doubt. It is readily identified as the only species of the genus with predominantly yellow hair and gold depressed hair­like scales on the dorsal surface of the thorax and abdomen.
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 21, DOI: 10.5281/zenodo.158466
Deltamys Thomas 1917
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Deltamys

description: Deltamys Thomas 1917
Deltamys Thomas 1917, Ann. Mag. Nat. Hist., ser. 8, 20: 98.
Type Species: Deltamys kempi Thomas 1917
Species and subspecies: 1 species:
Species Deltamys kempi Thomas 1917
Discussion: Akodontini. Described as a genus, but usually treated as a subgenus of Akodon (e.g., Cabrera, 1961; Ellerman, 1941; Musser and Carleton, 1993; Reig, 1987; Smith and Patton, 1999), though not uniformly (Gyldenstolpe, 1932; Massoia, 1980 b). Status of Deltamys recently argued as a genus (Bianchini and Delupi, 1994) and diagnosis so emended (González and Massoia, 1995). In cladistic analyses of allozymes (Barrantes et al., 1993) and gene sequences (D’Elía, 2003; D’Elía et al., 2003), D. kempi emerges as a basal sister-group to other Akodon sensu stricto. By itself, this cladistic dichotomy is ambiguous with regard to its ranking as merely distinctive subgenus or separate genus; the issue deserves further consideration based on a broader sampling of akodonts and other information.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1112, DOI: 10.5281/zenodo.7316535
Predictors of Nocturnal Hypoxemic Burden in Patients Undergoing Elective Coronary Artery Bypass Grafting Surgery
Creators: name: Tafelmeier, Maria
name: Blagoeva, Verka-Georgieva
name: Trum, Maximilian
name: Hegner, Philipp
name: Floerchinger, Bernhard
name: Camboni, Daniele
name: Creutzenberg, Marcus
name: Zeman, Florian
name: Schmid, Christof
name: Maier, Lars Siegfried
name: Wagner, Stefan
name: Linz, Dominik
name: Baumert, Mathias
name: Arzt, Michael
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: T90; nocturnal hypoxemia; sleep apnea; heart failure
subject: 610 Medizin

description: Nocturnal hypoxemia has been linked to increased cardiovascular morbidity and mortality. Several common diseases, such as sleep-disordered breathing (SDB), heart failure (HF), obesity, and pulmonary disease, coincide with an elevated nocturnal hypoxemic burden with and without repetitive desaturations. Research question: This study aimed to evaluate the association of relevant common diseases with distinctive metrics of nocturnal hypoxemic burden with and without repetitive desaturations in patients undergoing coronary artery bypass grafting surgery. Study design and methods: In this subanalysis of the prospective observational study, CONSIDER-AF (NCT02877745) portable SDB monitoring was performed on 429 patients with severe coronary artery disease the night before cardiac surgery. Pulse oximetry was used to determine nocturnal hypoxemic burden, as defined by total recording time spent with oxygen saturation levels < 90% (T90). T90 was further characterized as T90 due to intermittent hypoxemia (T90desaturation) and T90 due to nonspecific and noncyclic SpO2-drifts (T90non-specific). Results: Multivariable linear regression analysis identified SDB (apnea–hypopnea-index ≥ 15/h; B [95% CI]: 6.5 [0.4; 12.5], p = 0.036), obesity (8.2 [2.5; 13.9], p = 0.005), and mild-to-moderate chronic obstructive pulmonary disease (COPD, 16.7 [8.5; 25.0], p < 0.001) as significant predictors of an increased nocturnal hypoxemic burden. Diseases such as SDB, obesity and HF were significantly associated with elevated T90desaturation. In contrast, obesity and mild-to-moderate COPD were significant modulators of T90non-specific. Interpretation: SDB and leading causes for SDB, such as obesity and HF, are associated with an increased nocturnal hypoxemic burden with repetitive desaturations. Potential causes for hypoventilation syndromes, such as obesity and mild-to-moderate COPD, are linked to an increased hypoxemic burden without repetitive desaturations. Clinical Trial Registration: ClinicalTrials.gov identifier: NCT02877745.
title: Rahbān [Temple]
title: Rahbān Temple
titleType: AlternativeTitle
title: Rahbân
titleType: AlternativeTitle
title: Rahban
titleType: AlternativeTitle
title: Rḥbn
titleType: AlternativeTitle
title: Rhbn
titleType: AlternativeTitle
title: Raybūn
titleType: AlternativeTitle
title: Raybûn
titleType: AlternativeTitle
title: Raybun
titleType: AlternativeTitle
title: Rybn
titleType: AlternativeTitle
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Rahban Temple
South Arabia
Yemen
Hadramawt
Raybun
Pre-Islamic period
Religion
Polytheism
Cult
Temple

description: s.n. 2023. "Rahbān [Temple]". Thematic Dictionary of Ancient Arabia. Online edition 2023.
description: s.n. 2023. "Rahbān [Temple]". Thematic Dictionary of Ancient Arabia. Online edition 2023.
Calopteryx maculata Palisot de Beauvois 1807
Creators: name: Herhold, Hollister W
name: Davis, Steven R
name: Degrey, Samuel P
name: Grimaldi, David A
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Odonata
Calopterygidae
Calopteryx
Calopteryx maculata

description: Calopteryx maculata
“Ebony jewelwing”
Figures 38, 39 (lateral, anterior, posterior), 40 (dorsal), 41 (ventral)
Plates 21 (lateral), 22 (dorsal), 23 (ventral)
A single damselfly was scanned at 19 µm, which should have been sufficient to capture details of abdominal tracheae; however, this specimen was frozen to -20° C early in the study. As small tracheae were likely infilled, this specimen is not described in detail, but three-dimensional models are included in the online supplementary digital data.
The thoracic tracheae appear to be very similar to the aeshnid, along with extensive air sacs.
62 BULLETIN AMERICAN MUSEUM OF NATURAL HISTORY NO. 459
It is unclear whether there are four paired abdominal trunks as in the dragonfly, but it seems likely. Further studies should focus on Zygoptera in addition to more dragonfly specimens to verify and solidify tracheal patterns in the flight motor and abdomen.
description: Published as part of Herhold, Hollister W, Davis, Steven R, Degrey, Samuel P & Grimaldi, David A, 2023, COMPARATIVE ANATOMY OF THE INSECT TRACHEAL SYSTEM PART 1: INTRODUCTION, APTERYGOTES, PALEOPTERA, POLYNEOPTERA, pp. 1-184 in Bulletin of the American Museum of Natural History 459 (1) on pages 1-184, DOI: 10.5531/sd.sp.55, http://zenodo.org/record/7730159
Romero, Oscar A.: Die notwendige Revolution ; Für die Armen ermordet
Creators: name: Ossenbühl, K.H.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 24 (1983): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 24
Practical Computation of Graph VC-Dimension
Creators: name: Coudert, David
name: Csikós, Mónika
name: Ducoffe, Guillaume
name: Viennot, Laurent
Publisher: name: arXiv
Year: 2024
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: For any set system $H=(V,R), \ R \subseteq 2^V$, a subset $S \subseteq V$ is called \emph{shattered} if every $S' \subseteq S$ results from the intersection of $S$ with some set in $\R$. The \emph{VC-dimension} of $H$ is the size of a largest shattered set in $V$. In this paper, we focus on the problem of computing the VC-dimension of graphs. In particular, given a graph $G=(V,E)$, the VC-dimension of $G$ is defined as the VC-dimension of $(V, \mathcal N)$, where $\mathcal N$ contains each subset of $V$ that can be obtained as the closed neighborhood of some vertex $v \in V$ in $G$. Our main contribution is an algorithm for computing the VC-dimension of any graph, whose effectiveness is shown through experiments on various types of practical graphs, including graphs with millions of vertices. A key aspect of its efficiency resides in the fact that practical graphs have small VC-dimension, up to 8 in our experiments. As a side-product, we present several new bounds relating the graph VC-dimension to other classical graph theoretical notions. We also establish the $W[1]$-hardness of the graph VC-dimension problem by extending a previous result for arbitrary set systems.
Deltamys kempi Thomas 1917
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Deltamys
Deltamys kempi

description: Deltamys kempi Thomas 1917
Deltamys kempi Thomas 1917, Ann. Mag. Nat. Hist., ser. 8, 20: 98.
Type Locality: Argentina, Buenos Aires Prov., Río Paraná Delta, La Plata Estuary, Isla Ella, 1 m.
Vernacular Names: Kemp's Akodont.
Synonyms: Deltamys langguthi Massoia 1980; Deltamys langguthi González and Massoia 1995.
Distribution: EC Argentina, Uruguay, and SE Brazil (Rio Grande do Sul —González and Massoia, 1995; also see D’Elía et al., 2003:Fig. 1).
Conservation: IUCN – Lower Risk (lc) as Akodon kempi.
Discussion: Distribution and ecology reviewed by Massoia (1964); karyotype (2n = 35-38, FN = 38) and unique sex-determining mechanism described by Sbalqueiro et al. (1984) and Castro et al. (1991). Status of populations exhibiting different karyotypes (Castro et al., 1991) warrants further investigation. See González and Pardiñas (2002, Mammalian Species, 711).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1112, DOI: 10.5281/zenodo.7316535
Bombylius phaeopterus Bezzi 1924
Creators: name: Greathead, David J.
name: Evenhuis, Neal L.
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Bombyliidae
Bombylius
Bombylius phaeopterus

description: Bombylius phaeopterus Bezzi, 1924
(Fig. 11)
11. Bombylius modestus var. phaeopterus ɗɗΨΨ Eritrea: Assab, i–iii.1907 (Katona). MS page 6.
Bezzi, 1924: 46 – diagnosis; ɗ S. Abyssinia in BMNH.
Greathead, 1967: 210 – description of holotype [as B. phaeopteroides n. sp.; see Bowden (1975) for clarification of misidentification]; also recorded specimens from Yemen in BMNH.
Evenhuis & Greathead, 1999: 129 – listed (incorrectly) a holotype in BMNH.
Types: The syntypes in HNHM (of which there were an unknown number) were destroyed in 1956 leaving as the only surviving syntype the male from ‘S. Abyssinia’ in BMNH. This specimen is here designated lectotype (Fig. 11).
Remarks: This is one of a group of similar species close to B. modestus Loew, 1873 that are found in southern Arabia and northeastern Africa. They are keyed, described, and the male genitalia illustrated in Greathead (1967); but note that nomenclatural errors owing to application of the name B. phaeopterus to a common Eritrean coastal species (renamed B. modestoides Bowden) rather than the southern Ethiopian species designated in Bezzi (1924; syn. B. phaeopteroides Greathead) were corrected by Bowden (1975).
description: Published as part of Greathead, David J. & Evenhuis, Neal L., 2004, New species of Bombylioidea in Mario Bezzi's Unpublished Hungarian Museum Manuscript, pp. 1-56 in Zootaxa 773 on page 21, DOI: 10.5281/zenodo.158466
Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein
Creators: name: Perdiguero, Beatriz
name: Hauser, Alexandra
name: Gómez, Carmen Elena
name: Peterhoff, David
name: Sideris, Elefthéria
name: Sorzano, Carlos Óscar S.
name: Wilmschen, Sarah
name: Schaber, Marion
name: Stengel, Laura
name: Asbach, Benedikt
name: Ding, Song
name: Von Laer, Dorothee
name: Levy, Yves
name: Pantaleo, Giuseppe
name: Kimpel, Janine
name: Esteban, Mariano
name: Wagner, Ralf
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Introduction: The generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope (Env) trimers (sC23v4 KIKO and ConCv5 KIKO) for optimal display on the cell surface following homologous or heterologous vector delivery.
Methods: A combination of the following modifications scored best regarding the preservation of closed, native-like Env trimer conformation and antigenicity when using a panel of selected broadly neutralizing (bnAb) and non-neutralizing (nnAb) monoclonal antibodies for flow cytometry: i) replacing the natural cleavage site with a native flexible linker and introducing a single amino acid substitution to prevent CD4 binding (*), ii) fusing a heterologous VSV-G-derived transmembrane moiety to the gp140 C-terminus, and iii) deleting six residues proximal to the membrane.
Results: When delivering membrane-tethered sC23v4 KIKO* and ConCv5 KIKO* via DNA, VSV-GP, and NYVAC vectors, the two native-like Env trimers provide differential antigenicity profiles. Whereas such patterns were largely consistent among the different vectors for either Env trimer, the membrane-tethered ConCv5 KIKO* trimer adopted a more closed and native-like structure than sC23v4 KIKO*. In immunized mice, VSV-GP and NYVAC vectors expressing the membrane-tethered ConCv5 KIKO* administered in prime/boost combination were the most effective regimens for the priming of Env-specific CD4 T cells among all tested combinations. The subsequent booster administration of trimeric ConCv5 KIKO* Env protein preserved the T cell activation levels between groups. The evaluation of the HIV-1-specific humoral responses induced in the different immunization groups after protein boosts showed that the various prime/boost protocols elicited broad and potent antibody responses, preferentially of a Th1-associated IgG2a subclass, and that the obtained antibody levels remained high at the memory phase.
Discussion: In summary, we provide a feasible strategy to display multiple copies of native-like Env trimers on the cell surface, which translates into efficient priming of sustained CD4+ T cell responses after vector delivery as well as broad, potent, and sustained antibody responses following booster immunizations with the homologous, prefusion-stabilized, close-to-native ConCv5 KIKO* gp140 Env trimer.