cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder
Creators: name: Kohler, Robert J.
name: Zhornitsky, Simon
name: Potenza, Marc N.
name: Yip, Sarah W.
name: Worhunsky, Patrick
name: Angarita, Gustavo A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Neuroscience
Pharmacology
Mental Health

description: Background: Individual differences in gray-matter morphometry in the limbic system and frontal cortex have been linked to clinical features of cocaine use disorder (CUD). Self-administration paradigms can provide more direct measurements of the relationship between the regulation of cocaine use and gray-matter morphometry when compared to self-report assessments. Objectives: Our goal was to investigate associations with self-administration behavior in subcortical and cortical brain regions. We hypothesized the number of cocaine infusions self-administered would be correlated with gray-matter volumes (GMVs) in the striatum, amygdala, and hippocampus. Due to scarcity in human studies, we did not hypothesize subcortical directionality. In the frontal cortex, we hypothesized thickness would be negatively correlated with self-administered cocaine. Methods: We conducted an analysis of cocaine self-administration and structural MRI data from 33 (nFemales = 10) individuals with moderate-to-severe CUD. Self-administration lasted 60-minutes and cocaine (8, 16, or 32 mg/70 kg) was delivered on an FR1 schedule (5-minute lockout). Subcortical and cortical regression analyses were performed that included combined bilateral regions and age, experimental variables and use history as confounders. Results: Self-administered cocaine infusions were positively associated with caudal GMV (b = 0.18, p = 0.030) and negatively with putamenal GMV (b = −0.10, p = 0.041). In the cortical model, infusions were positively associated with insular thickness (b = 0.39, p = 0.008) and women appeared to self-administer cocaine more frequently (b = 0.23, p = 0.019). Conclusions: Brain morphometry features in the striatum and insula may contribute to cocaine consumption in CUD. These differences in morphometry may reflect consequences of prolonged use, predisposed vulnerability, or other possibilities. Clinical Trial Numbers: NCT01978431; NCT03471182
title: Russlands Überfall auf die Ukraine – Eine Zeitenwende?
Creators: name: Peters, Florian
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: "Zeitenwende": gleich mehrfach gebrauchte Bundeskanzler Olaf Scholz in seiner Regierungserklärung zum Krieg in der Ukraine am 27. Februar im Deutschen Bundestag dieses Wort, um zu beschwören, dass seit dem russischen Überfall auf die Ukraine plötzlich alles ganz anders sei. Außenministerin Annalena Baerbock hatte schon am Morgen des russischen Überfalls bekundet: „Wir sind heute in einer anderen Welt aufgewacht.“
Doch provozieren die großen Worte von der Zeitenwende die Skepsis des Zeithistorikers. Mit einigem zeitlichen Abstand hat sich schon manche eilig ausgerufene historische Zäsur als weniger einschneidend erwiesen, als sie im Eifer des Moments noch scheinen mochte.
Im Falle der deutschen Bundesregierung stößt die eminent politische Absicht, mit der der russische Angriffskrieg zum unvorhersehbaren historischen Wendepunkt erklärt wird, übel auf.
title: An assessment of geothermal energy potential for power generation in Iran
Creators: name:  Seyedrahimi-Niaraq ,   Mirmahdi
name:  Taherdangkoo ,   Reza
name:  Ardejani ,   Faramarz Doulati
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Energy generated from geothermal systems is a good alternative to non-renewable fossil fuels and plays an important role in reducing greenhouse gas emissions. Geothermal energy is generated from the inner parts of the earth as tangible heat. The geothermal energy is distributed between the host rock and the natural fluid contained in fractures and pore spaces of the rocks in the earth's crust. Suitable areas for the exploitation of geothermal energy are related to tectonic activities and hot spots of the earth, which have signs of surface activities such as hot springs, geysers and volcanic rocks. Iran, under the influence of these tectonic and volcanic activities, has large sources of geothermal energy. A geothermal power plant with a capacity of 5 MWe is being built in the Meshkinshahr volcanic zone in the northwest Iran. This research aims to evaluate these resources for electricity generation by studying the available data obtained from the surface and subsurface exploration activities for the entire country. The results of exploratory studies in five provinces of Iran have led to introduction of 35 potential geothermal areas. Among them, the subsurface data of the northwest of Sabalan reveals that this area has a potential electricity generation capacity of about 50 MW. Further investigations and investments are required in particular in the zones where there exist high-temperature hot springs. Therefore, the capacity of electricity generation in this field would be significantly increased.
title: Wiederauferstehung oder erneuter Untergang der UdSSR? Die Putin-Doktrin
Creators: name: Schattenberg, Susanne
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Die Welt befindet sich noch immer im Schock, weil niemand glaubte, Putin würde tatsächlich die Ukraine überfallen. Von den drei Szenarien angesichts des seit Herbst letzten Jahres nicht abreißenden russischen Truppenaufmarschs an der ukrainischen Grenze war dies das unwahrscheinlichste. Viel zu hoch erschien das Risiko: Wie würde Putin seiner Bevölkerung einen Krieg gegen das „Brudervolk“ verkaufen, wie seine kriegsabgeneigte Bevölkerung auf unzählige Tote vorbereiten? Der Fehler lag darin, nicht in Putins Propaganda-Kategorien zu denken, mit denen der Krieg zur „Spezialoperation“ und der Angriff zur „Befreiung“ wurde. Das noch größere Versäumnis lag darin, dass wir Russlandkenner*innen nicht mit Militärstrateg*innen sprachen, die hätten erläutern können, dass Putin nach dem Lehrbuch des Krieges im 21. Jahrhundert vorgehen würde: erst mit Raketen und schwerer Artillerie alles ausschalten, was die dann nachrückenden Soldaten gefährden könnte. In einem solchen chirurgischen Eingriff – den Feind wehrlos bomben, reingehen, die Regierung austauschen und wieder rausgehen – sah Putin offenbar eine reelle, wenn auch riskante, inzwischen vielleicht gescheiterte Chance, das wahrzumachen, was er bereits im Juli 2021 in einem historischen Essay zu Papier gebracht hatte: die Ukraine Russland wieder einzuverleiben.
title: Verändert der Krieg alles? Wie Russland und die Ukraine für ihr Militär werben
Creators: name: Peters, Florian
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Viele wundern sich dieser Tage über den kometenhaften Aufstieg des ukrainischen Präsidenten Wolodymyr Selenskyj zu einem globalen Medienstar. Besonders augenfällig wird dies durch den grellen Kontrast zur medialen Inszenierung seines Widerparts im Kreml. Selenskyj lässt Putin alt aussehen, doch hinter seinem internetaffinen, von Videoclips und Selfie-Ästhetik inspirierten Kommunikationsstil stehen mehr als nur ein paar gute PR-Strategen. Dass der ukrainische Präsident sich der „sozialen Medien“ virtuos zu bedienen weiß, hat er nicht erst seit Kriegsausbruch unter Beweis gestellt. Dass die ukrainische Führung nun auch in ihrer Kriegspropaganda erfolgreich auf Interaktion und Nähe setzt, ist nicht zuletzt ein Gradmesser für den Stand der öffentlichen Kommunikation in der sich demokratisierenden ukrainischen Gesellschaft.
Attitudes toward medications for opioid use disorder among peer recovery specialists
Creators: name: Pasman, Emily
name: Lee, Guijin
name: Singer, Samantha
name: Burson, Nick
name: Agius, Elizabeth
name: Resko, Stella M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Background: Peer recovery specialists (PRSs) are substance use service providers with lived experience in recovery. Although a large body of research demonstrates the efficacy of medications for opioid use disorder (MOUD), emerging research suggests PRSs’ attitudes toward MOUD are ambivalent or mixed. Few studies have quantitatively assessed factors influencing PRSs’ attitudes. Objectives: This study identifies personal and professional characteristics associated with attitudes toward MOUD among PRSs. Methods: PRSs working at publicly funded agencies in Michigan completed a self-administered web-based survey (N = 266, 60.5% women). Surveys assessed socio-demographics, treatment and recovery history, attitudes toward clients, and attitudes toward MOUD. Multiple linear regression was used to identify factors associated with attitudes toward MOUD. Results: A minority of PRSs (21.4%) reported a history of treatment with MOUD, while nearly two-thirds reported current 12-step involvement (62.5%). Compared to PRSs without a history of MOUD treatment, PRSs who had positive (b = 4.71, p < .001) and mixed (b = 3.36, p = .010) experiences with MOUD had more positive attitudes; PRSs with negative experiences with MOUD had less positive attitudes (b = −3.16, p = .003). Current 12-step involvement (b = −1.63, p = .007) and more stigmatizing attitudes toward clients (b = −.294, p < .001) were associated with less positive attitudes toward MOUD. Black PRSs had less positive attitudes than White PRSs (b = −2.50, p = .001), and women had more positive attitudes than men (b = 1.19, p = .038). Conclusion: PRSs’ attitudes toward MOUD varied based on the nature of their lived experience. Findings highlight considerations for training and supervising PRSs who serve individuals with opioid use disorder.
Chemical characterization of the brown seaweed Cystoseira compressa collected from the Algerian coast: a promising source for biostimulant metabolites
Creators: name: Rabhi, Mohamed Lamine
name: Zouaoui, Ahmed
name: Yildiz, Ilyas
name: Salmi, Imen
name: Metidji, Hafidha
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: This study aimed to investigate the chemical composition of the brown seaweed Cystoseira compressa collected from the Algerian coast, focusing on phytohormone, amino acid, and sugar ­profiles. LC-MS/MS analysis of the amino acid profile revealed high levels of L-alanine (23.10 mg/100g extract), L-glutamic acid (19.75 mg/100g extract), and L-aspartic acid (14.53 mg/100g extract), HPLC analysis identified key phytohormones, with zeatin (243.96 mg/100g extract) being the most abundant. Significant quantities of essential sugars, including arabinose (4002 mg/100g extract) and sucrose (3667 mg/100g extract), were also detected. The findings of this research deepen our understanding of key metabolites in Cystoseira compressa that support plant growth and nutrition and suggest a significant potential for developing seaweed-based biostimulants, emphasising the value of using marine resources to improve agricultural practices.
Comparison between invasive intervention and conservative treatment in patients with in-hospital myocardial infarctions : results from the Regional Myocardial Infarction Registry of Saxony-Anhalt (RHESA) Study
Creators: name: Assaf, Mohamad
name: Costa, Daniela
name: Efremov, Ljupcho
name: Holland, Karen
name: Mikolajczyk, Rafael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Background/Objectives: In-hospital myocardial infarctions (AMIs) are less often treated with invasive intervention, compared to out-of-hospital AMIs. We aimed to identify the determinants of invasive intervention in patients with in-hospital AMIs and assess its association with mortality, compared to conservative treatment. Methods: This was a cross-sectional study of in-hospital AMIs in The Regional Myocardial Infarction Registry of Saxony-Anhalt. Patients’ characteristics and outcomes were compared based on the treatment strategy (invasive intervention vs. conservative treatment). Logistic regression was performed to assess the determinants of invasive intervention (vs. conservative treatment) and its association with 30-day mortality. Results: Nearly 67% of the patients (259/386) received invasive intervention, and the rest were treated conservatively. Those who were treated with an invasive intervention were younger and had a lower proportion of chronic heart failure than those treated conservatively. Age > 75 years compared to younger patients, pre-existing heart failure, and higher heart rate upon presentation were associated with lower odds of receiving invasive intervention. Hypertension (OR = 2.86, 95% CI [1.45–5.62]) and STEMI vs. NSTEMI (1.96, [1.10–3.68]) were associated with higher odds of invasive intervention. The adjusted odds of 30-day mortality were lower with invasive intervention compared to conservative treatment (0.25, [0.10–0.67]). Conclusions: One-third of the patients with in-hospital AMIs received conservative treatment. Younger age, absence of heart failure, lower heart rate, hypertension, and STEMI were determinants of invasive intervention usage. Invasive intervention had lower odds of 30-day mortality, but longitudinal studies are still needed to assess the efficacy of conservative vs. invasive strategies in in-hospital AMIs.
The addition of alpha-ketoglutarate to NT-proBNP improves the prediction of long-term all-cause mortality in acute heart failure patients
Creators: name: Xu, Tianyu
name: Zhang, Hao
name: Peng, Zhengliang
name: Huang, Yuli
name: Zhan, Qiong
name: Ma, Zhuang
name: Zeng, Xianghui
name: Liu, Chen
name: Zeng, Qingchun
name: Dong, Yugang
name: Xu, Dingli
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Alpha-ketoglutarate (AKG), is a major intermediate metabolite of the tricarboxylic acid cycle, and is closely associated with cardiometabolic disease prognosis. Previous studies indicated that AKG is related to myocardial energy expenditure levels and reflects adverse short-term outcomes in heart failure (HF) patients. In this prospective cohort study, we examined the long-term prognostic value of AKG levels in acute HF (AHF) patients. Plasma AKG levels were assessed in patients hospitalized with AHF. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality were calculated via multiple Cox regression. All-cause mortality was compared between patients with NT-proBNP < 1000 pg/ml and those with NT-proBNP ≥ 1000 pg/ml via subgroup analysis. Patients with AKG ≥ 9.83 μg/ml had higher heart rates and NT-proBNP and lower left ventricular ejection fraction (LVEF) and systolic blood pressure (SBP). After multiple adjustment, higher AKG was associated with an increased all-cause mortality risk (HR = 1.078, p < 0.001). Compared with AKG < 9.83 μg/ml, AKG ≥ 9.83 μg/ml nearly doubled (HR = 1.929, p < 0.001) and quadrupled (HR = 4.160, p < 0.001) the all-cause mortality risk in patients with NT-proBNP ≥ 1000 pg/ml and those with NT-proBNP < 1000 pg/ml, respectively. Plasma AKG was independently associated with greater all-cause mortality risk in patients with AHF. Higher AKG levels retained prognostic value for patients with relatively low NT-proBNP. AKG was an independent factor associated with a greater risk of long-term outcomes in patients with AHF. Elevated AKG was significantly related to a worse prognosis in AHF patients with NT-proBNP < 1000 pg/ml, especially in those patients with persevered ejection fraction. AKG could be used as an additive metabolic biomarker combined with NT-proBNP for long-term outcome prediction in AHF patients, especially in those with relatively low NT-proBNP levels.
Extraction of copper from copper concentrate by indigenous association of iron-oxidizing bacteria
Creators: name: Vardanyan, Arevik
name: Willscher, Sabine
name: Jost, Manuel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 540

description: Bioleaching of Cu from the copper concentrate of Armanis gold-bearing polymetallic ore (Armenia) was investigated. The main objective was revealing high active bacteria and their association, as well as optimizing the bioleaching process with their application to ensure the most efficient recovery of copper from the tested concentrate. To obtain optimal bacterial associations, bottom-up and top-down approaches were used. Bioleaching of copper concentrate was carried out using pure cultures of iron- and sulfur-oxidizing bacteria and their mixed culture, as well as indigenous bacterial consortium. Comparative studies of copper bioleaching by mixed cultures of Acidithiobacillus caldus, Leptospirillum ferriphilum CC, Sulfobacillus thermosulfidooxidans 6, and indigenous consortium Arm of iron-oxidizing bacteria were performed. At the beginning of bioleaching, the amounts of extracted copper by mixed culture and Arm consortium were equal; afterward, between 20–27 days, the Arm indigenous consortium showed significantly higher activity in terms of copper extraction. In parallel, mineralogical and liberation analyses of feed material and bioleaching residues were performed.
Deciphering the role of alternative splicing in neoplastic diseases for immune-oncological therapies
Creators: name: Bauer, Marcus
name: Schöbel, Chiara-Maria
name: Wickenhauser, Claudia
name: Seliger, Barbara
name: Jasinski-Bergner, Simon
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: Alternative splicing (AS) is an important molecular biological mechanism regulated by complex mechanisms involving a plethora of cis and trans-acting elements. Furthermore, AS is tissue specific and altered in various pathologies, including infectious, inflammatory, and neoplastic diseases. Recently developed immuno-oncological therapies include monoclonal antibodies (mAbs) and chimeric antigen receptor (CAR) T cells targeting, among others, immune checkpoint (ICP) molecules. Despite therapeutic successes have been demonstrated, only a limited number of patients showed long-term benefit from these therapies with tumor entity-related differential response rates were observed. Interestingly, splice variants of common immunotherapeutic targets generated by AS are able to completely escape and/or reduce the efficacy of mAb- and/or CAR-based tumor immunotherapies. Therefore, the analyses of splicing patterns of targeted molecules in tumor specimens prior to therapy might help correct stratification, thereby increasing therapy success by antibody panel selection and antibody dosages. In addition, the expression of certain splicing factors has been linked with the patients’ outcome, thereby highlighting their putative prognostic potential. Outstanding questions are addressed to translate the findings into clinical application. This review article provides an overview of the role of AS in (tumor) diseases, its molecular mechanisms, clinical relevance, and therapy response.
The effect of soil moisture content and soil texture on fast in situ pH measurements with two types of robust ion-selective electrodes
Creators: name: Vogel, Sebastian
name: Emmerich, Katja
name: Schröter, Ingmar
name: Bönecke, Eric
name: Schwanghart, Wolfgang
name: Rühlmann, Jörg
name: Kramer, Eckart
name: Gebbers, Robin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 630

description: In situ soil pH measurements with ion-selective electrodes (ISEs) are receiving increasing attention in soil mapping for precision agriculture as they can avoid time-consuming sampling and off-site laboratory work. However, unlike the standard laboratory protocol, in situ pH measurements are carried out at lower and varying soil moisture contents (SMCs), which can have a pronounced effect on the sensor readings. In addition, as the contact with the soil during in situ measurements should be relatively short, effects of soil texture could be expected because texture controls the migration of protons to the electrode interface. This may be exacerbated by the fact that the electrodes used for in situ measurements are made of less sensitive but more robust materials as compared to the standard glass electrode. Therefore, the aim of the present study was to investigate the effect of soil moisture and soil texture on pH measurements using robust antimony and epoxy-body ISEs pressed directly into the soil for 30 s. The SMC was gradually increased from dry conditions to field capacity. A wide range of soil texture classes were included, with sand, silt, and clay contents ranging from 16 % to 91 %, 5 % to 44 %, and 4 % to 65 %, respectively. An exponential model was fitted to the data to quantify the relationship between SMC and pH. The results show that an increase in SMC causes a maximum increase in pH of approximately 1.5 pH units, regardless of the type of pH ISE used. Furthermore, for sandy soil textures, a rather linear relationship between pH and SMC was observed, whereas, with decreasing mean particle diameter (MPD), the model had a pronounced exponential shape, i.e., a greater pH increase at low SMC and a plateau effect at high SMC. With increasing SMC, the pH values asymptotically approached the standard pH measured with a glass electrode in 0.01 M CaCl2 (soil : solution ratio of 1:2.5). Thus, at high SMC, subsequent calibration of the sensor pH values to the standard pH value is negligible, which may be relevant for using the sensor pH data for lime requirement estimates. The pH measurement error decreases exponentially with increasing soil moisture and increases with decreasing MPD. Using a knee point detection, reliable pH values were obtained for SMC > 11 %, irrespective of the pH ISE used. An analysis of the regression coefficients of the fitted exponential model showed that the maximum pH increase also depends on soil texture; i.e., the influence of soil moisture variation on the pH value increases with decreasing MPD. Moreover, the concavity of the exponential curve increases with decreasing MPD.
title: Kiew im Februar 2022. Ein Forschungsaufenthalt in einer bedrohten Stadt
Creators: name: Hoppe, Bert
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Am 15. Februar, etwas mehr als eine Woche vor Beginn der russischen Invasion in die Ukraine, war ich zum letzten Mal im Archiv des ukrainischen Geheimdienstes SBU. Als ich mich von der Lesesaalaufsicht verabschiedete und ihr sagte, ich hoffe, bald zurückkehren zu können, blickte ein älterer Nutzer auf. Wo ich denn herkomme. „Aus Berlin“, antwortete ich. "Ach so", sagte er und schaute wieder in seine Akten, "aus Deutschland. Na, großartig. Ihr Deutschen schickt uns 5000 Helme, und die Russen lassen demnächst Raketen auf uns niederregnen." Zum ersten Mal in meinem Leben habe ich mich für mein Land geschämt und für meine Regierung, die der Ukraine die angeforderte Unterstützung mit Hinweis auf unsere Geschichte versagte – auf eben jene Geschichte, die ich gerade in Kiew erforschte. 
Ich war vier Wochen lang in der ukrainischen Hauptstadt, bis ich meinen Aufenthalt vorzeitig abbrechen musste. Vom ersten Tag an spürte ich den eigentümlichen Schwebezustand, in dem sich das ganze Land befand. Der Alltag in der großen Metropole lief weiter, ungeachtet der immer bedrohlicheren Nachrichten. Im persönlichen Gespräch hingegen bot sich ein anderes Bild. Zwar blieb der offen ausgesprochene Pessimismus des Nutzers im SBU-Archiv die Ausnahme, Illusionen machte sich aber niemand.
SHAPING E-COMMERCE PIONEERS: THE IMPACT OF FLIPPED CLASSROOM ON 'CROSS-BORDER E-COMMERCE OPERATIONS
Creators: name: Li, Wei Qiang
Publisher: name: ZAP journals
Year: 2024
Subjects: Cross-Border E-commerce, Flipped Classroom, Active Learning, Vocational Education, Student Engagement

description: The course "Cross-Border E-commerce Operations" in higher vocational colleges is designed to bolster students' practical skills and employability. However, traditional teaching methods, characterized by one-way lectures, often result in passive learning and hinder educational outcomes. This paper addresses the imperative need to transition from passive to active learning.

Students majoring in cross-border e-commerce typically exhibit a keen interest in emerging electronic products, new media, and social software. They are often outgoing and lively in nature, making them well-suited for the field. Nonetheless, several challenges hinder their professional development, including misconceptions about quick wealth in e-commerce and struggles with English language proficiency. Furthermore, inadequate computer skills and a lack of proactive learning are impediments to their progress.

In response, this paper explores the implementation of the flipped classroom model, which blends teaching with real-world enterprise operations. This student-centered approach empowers learners to take the initiative in their education, transforming the learning experience into an engaging journey resembling a game. Moreover, the integration of 1+X certificates and skill competitions augments students' sense of accomplishment in the classroom
Broad-spectrum in vitro activity of Nα-aroyl-N-aryl-phenylalanine amides against non-tuberculous mycobacteria and comparative analysis of RNA polymerases
Creators: name: Lang, Markus
name: Ganapathy, Uday S.
name: Abdelaziz, Rana
name: Dick, Thomas
name: Richter, Adrian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: This study investigates the in vitro activity of Nα-aroyl-N-aryl-phenylalanine amides (AAPs), previously identified as antimycobacterial RNA polymerase (RNAP) inhibitors, against a panel of 25 non-tuberculous mycobacteria (NTM). The compounds, including the hit compound MMV688845, were selected based on their structural diversity and previously described activity against mycobacteria. Bacterial strains, including the M. abscessus complex, M. avium complex, and other clinically relevant NTM, were cultured and subjected to growth inhibition assays. The results demonstrate significant activity against the most common NTM pathogens from the M. abscessus and M. avium complexes. Variations in activity were observed against other NTM species, with for instance M. ulcerans displaying high susceptibility and M. xenopi and M. simiae resistance to AAPs. Comparative analysis of RNAP β and β′ subunits across mycobacterial species revealed strain-specific polymorphisms, providing insights into differential compound susceptibility. While conservation of target structures was observed, differences in compound activity suggested influences beyond drug–target interactions. This study highlights the potential of AAPs as effective antimycobacterial agents and emphasizes the complex interplay between compound structure, bacterial genetics, and in vitro activity.
title: Sprache als Waffe. "Neonazis", "Genozid", "Entnazifizierung" und "Sondereinsatz" in der Kriegspropaganda Putins
Creators: name: Penter, Tanja
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Mich erreichen in diesen Tagen dramatische Nachrichten aus der Ukraine. Als Historikerin, die seit vielen Jahren über die Geschichte des deutschen Vernichtungskriegs in der Ukraine forscht, bin ich erschüttert mitzuerleben, wie Putins menschenverachtender Krieg mit seiner ganzen Brutalität in den Alltag der Menschen in der Ukraine eingebrochen ist.
Jetzt ist die Rede von einer Zeitenwende. Wie schon 2014 bei der Annexion der Krim und der Entzündung eines Stellvertreterkriegs im Donbass. Trotzdem sind die damaligen Ereignisse in der europäischen Öffentlichkeit schnell wieder in Vergessenheit geraten, genauso wie der Krieg in Georgien 2008. Im Rückblick wächst die Einsicht, dass wir in Deutschland und Europa durch jahrelange Fehleinschätzungen und zögerliches Handeln eine Mitschuld daran tragen, dass Putin die „rote Linie“ immer weiter nach vorne geschoben hat.
FAIRfest 2025 - A for Accessibility: Semantic Artefacts
Creators: name: Jonquet, Clement
name: Kesäniemi, Joonas
Publisher: name: Zenodo
Year: 2025
Subjects: subject: semantic artefact
subject: FAIR principles
subject: Semantic web
subject: Ontology

description: This joint plenary session will highlight the transformative contributions of FAIR-IMPACT and FAIRCORE4EOSC projects to advancing FAIR principles in the domain of semantics: metadata & ontologies, mappings, and research software. The session will open with a keynote from a distinguished expert reporting on the current status and challenge related to the topic within EOSC. The core of the session will feature presentations on key achievement related to theme of the session from the two projects, including guidelines for Research Software Metadata, recommendations for FAIR Semantic Artefacts and FAIR mappings as well as development and setting up of concrete services such as the MSCR and the DTR from FAIRCORE4EOSC and multiple semantic artefacts catalogues from FAIR-IMPACT. The session will conclude with a forward-looking panel discussion, exploring lessons learned, assessing the alignment of outcomes with EOSC objectives, and identifying priorities for future research. This plenary session offers a unique opportunity to reflect on achievements, evaluate the impact, and collaboratively envision the future of FAIR-compliant and semantically enabled science within EOSC.
R for Reusability: Certification, metrics & guidelines for FAIR data and software - An interactive session: is FAIR enough?
Creators: name: Gruenpeter, Morane
name: Verburg, Maaike
name: Priddy, Mike
name: Hugo, Wim
name: L'Hours, Hervé
name: Breitmoser, Elena
name: Ioannidis, Alex
name: Garijo, Daniel
name: Chue Hong, Neil
Publisher: name: Zenodo
Year: 2025
Subjects: Reusability
FAIR
Data repositories

description: Are the FAIR principles enough for reusability?

What questions about Reusability have you always wondered about but never dared to ask? In the session R for Reusability, we explore the question: Are the FAIR principles enough for reusability? This is not your standard panel discussion, but a more interactive format where you get to know your neighbours and ask the hard-hitting questions to our panel of experts. We will reflect on our own services and solutions and consider what they contribute to Reusability, opening up to critical questions, suggestions, and considering use cases from you.

In the R for Reusability session, the following services and tools were presented:

F-UJI,

Compliance Assessment Toolkit,

Trustworthy and FAIR-enabling Repositories Prototype

Zenodo/InvenioRDM APIs and Connector to SWH

The Ontology Pitfall Scanner for FAIR 

You can find the slides with links and the live notes used by the online participants.
title: Weltkulturerbe in Gefahr! Zur Lage ukrainischer Museen, Bibliotheken und Architekturdenkmäler im Krieg
Creators: name: Kuhr-Korolev, Corinna
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Die Erinnerung an den Zweiten Weltkrieg ist im Krieg in der Ukraine allgegenwärtig. Die alten Menschen, die oft nicht mehr fliehen wollen oder können, erinnern sich an ihre Kindheit im Krieg. Sie erinnern sich an die deutsche Besatzung, an die Zerstörung ihrer Städte, an den mühsamen Wiederaufbau und an die Hoffnungen, die sie in die neue Staatlichkeit setzten.
Eine tragische Wiederholung ist auch das Schicksal der Kulturgüter. Vieles wurde während des Zweiten Weltkriegs zerstört, verbrannt oder verschleppt. Noch immer vermissen ukrainische Museen und Bibliotheken große Teile ihrer Sammlungen. Gerade erst konnten Verlustkataloge abgeschlossen werden. Einige wenige Rückgaben von Kunstwerken, Büchern und Dokumenten gab es in den letzten Jahren, aber solche Fälle sind die Ausnahme. Nun droht erneut die Gefahr, dass einzigartiges Kulturerbe zerstört und damit ein Teil der ukrainischen Identität ausgelöscht wird.
title: Wenn es ernst wird. Mit Karl Schlögel im "Situation Room" der Zeitgeschichte
Creators: name: Kindler, Robert
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: "Entscheidung in Kiew. Ukrainische Lektionen" – so hat Karl Schlögel sein 2015 veröffentlichtes Buch über die Ukraine betitelt. Drei Punkte sind es, die den Band im März 2022 zu einer ebenso fesselnden wie aufwühlenden Lektüre machen.
Erstens sind da die politischen Einschätzungen und Prognosen, die klingen, als entstammten sie unserer unmittelbaren Gegenwart. Zweitens faszinieren Schlögels Essays über (sowjet-)ukrainische Städte, die zwischen 1988 und 2015 verfasst wurden und die den größten Teil des Buches ausmachen. Manches von dem, was er etwa in Charkiw noch sah, in dieser "Stadt, die weiß, was auf dem Spiel steht und dass jederzeit alles verloren sein kann" (S. 181), ist jetzt bereits durch russische Raketen zerstört. Und drittens unterzieht er seine Doppelrolle als Historiker des sowjetischen Imperiums und teilnehmender Beobachter epochaler Zeitenwenden einer selbstkritischen Revision. Daran schließt sich die Frage an, was Zeithistorikerinnen und -historiker konkret tun können, wenn es ernst wird.
title: Osteuropa (ver)lernen. Ein Plädoyer für eine neue Geschichtskultur
Creators: name: Satjukow, Elisa
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: In der Ukraine ist Krieg und allerorts wird die Forderung nach mehr Osteuropa-Expertise laut. Das Problem ist jedoch nicht nur fehlende Expertise, sondern die Sonderrolle der Osteuropaforschung im deutschen Wissenschaftssystem. Über den langen Weg zu einem integrativen Geschichtsverständnis.
title: Image and Reality: Career Goals of Educated Ugandan Women
Creators: name: Schimmel, Gordon
name: Evans, David R.
Publisher: name: Center for International Education, UMass Amherst
Year: 1972
Subjects: subject: Uganda; Education; Girls Education; Tororo Girls School

description: This paper presents an initial exploration of the relationship between the employment and the training of women in the context of a single African country, Uganda. It begins with an analysis of the present and projected employment picture for women in relationship to the number of secondary school girls. The analysis then focuses on job aspirations and expectations of girls in secondary schools, at both the lower and higher school level. Differences between expectations and probable opportunities are discussed and related to certain differences in secondary schools.
title: Konflikte, Engagement und Ängste. Der Ukrainekrieg in den Augen postsowjetischer Migrant:innen in Deutschland
Creators: name: Aivazishvili-Gehne, Nino
name: Jašina-Schäfer, Alina
name: Panagiotidis, Jannis
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Der Krieg in der Ukraine betrifft Deutschlands Einwohner:innen auf unterschiedliche Art und Weise. Er durchdringt die Stadt- und Privaträume anders, aktualisiert unterschiedliche Erinnerungen und ruft verschiedene (Re)aktionen hervor. Er beherrscht nun fast jedes Gespräch, das man zufällig auf der Straße, in einem Café oder Geschäft überhört. Aufgrund ihrer eigenen Herkunft fühlen sich die Menschen aus der ehemaligen Sowjetunion in Deutschland – die postsowjetischen Migrant:innen – besonders von diesem Krieg betroffen, egal wie sie zu ihm stehen. Der Krieg hat direkte Auswirkungen auf ihre Lebenswelten, er betrifft Familienangehörige und Freunde sowohl in der Ukraine als auch in Russland, und er hinterlässt Spuren in den hiesigen Communities. Entsprechend wichtig ist eine differenzierte Betrachtung. Denn es gibt nicht die Einstellung der postsowjetischen Migrant*innen zum Krieg. Hier können wir nur ein paar Schlaglichter werfen.
title: Plátano :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants..,
Publisher: name: International Union for the Protection of New Varieties of Plants
Year: 0
Subjects: New Varieties of Plants
Banana

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
title: ARCHIV MACHT WISSEN. Die Ukraine als Aufgabe einer europäischen Geschichtswissenschaft
Creators: name: Lehmann, Maike
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Szenen aus einem Werbeclip sind mit der russischen Invasion Realität geworden: Taxifahrer und Geologiestudenten, Väter und Söhne, Programmierer und Vorarbeiter, Fußballfans und Nachbarn verteidigen mit Waffen ihre Heimat, wo russische Bomben Wohngebiete, Krankenhäuser, Kirchen und Museen treffen. Für Gesellschaften jenseits der Ostgrenze der EU ist es atemberaubend solche Taten anzusehen. Zugleich bemühen sich hier viele, Hilfe zu leisten durch Geld- und Sachspenden, Hilfsdienste an Bahnhöfen und Angebote für die Aufnahme des größten Flüchtlingsstroms, den Europa seit 1945 gesehen hat. Auch die Wissenschaft ist nicht untätig geblieben.
Zugleich hat dies alles historische Dimensionen. Dementsprechend haben Historiker:innen in der Ukraine ein Soundarchiv gegründet, um die Auswirkungen des Krieges in Podcasts zu dokumentieren. Hier spielt das renommierte Center for Urban History in Lwiw eine zentrale Rolle; es sammelt zugleich private Aufnahmen vom Kriegsalltag für sein Urban Media Archive. Und es hat ein Oral History Projekt gestartet, um die Erfahrungen der ersten Kriegstage weiter zu dokumentieren. Aber auch in Kiew und anderen Städten scannen Archivar:innen fieberhaft die Bestände – Bomben- und Granatangriffen zum Trotz.
Dabei ist nicht zu vergessen, dass all diese Menschen nicht nur Kämpfer:innen und Geflüchtete sind. In ihren Heimatstädten stehen Lebensräume, Erinnerungsorte und Gedächtnisspeicher unter Beschuss, die ihr Leben geprägt haben. Sie bei der Bewahrung und dem (Wieder-)Aufbau dieser Speicher zu unterstützen, ist die Kernaufgabe einer europäischen Geschichtswissenschaft.
Better Together: Photoredox/Copper Dual Catalysis in Atom Transfer Radical Polymerization
Creators: name: Sobieski, Julian
name: Gorczyński, Adam
name: Jazani, Arman Moini
name: Yilmaz, Gorkem
name: Matyjaszewski, Krzysztof
Publisher: name: Zenodo
Year: 2025

description: Photomediated Atom Transfer Radical Polymerization (photoATRP) is an activator regeneration method, which allows for the controlled synthesis of well-defined polymers via light irradiation. Traditional photoATRP is often limited by the need for high-energy ultraviolet or violet light. These could negatively affect the control and selectivity of the polymerization, promote side reactions, and may not be applicable to biologically relevant systems. This drawback can be circumvented by an introduction of the catalytic amount of photocatalysts, which absorb visible and/or NIR light and, therefore, controlled, regenerative ATRP can be performed with the dual-catalytic cycle. Herein, a critical summary of recent developments in the field of dual-catalysis concerning Cu-catalyzed ATRP is provided. Contributions of involved species are examined mechanistically, followed by challenges and future directions towards the next generation of advanced functional macromolecular materials.
description: Financial support from NSF (CHE 2401112) and National Science Centre, Poland (UMO-2020/39/D/ST4/01182) is gratefully acknowledged. Adam Gorczyński is a scholarship holder of the Polish Ministry of Education and Science for outstanding young scientists. A.M.J. acknowledges the Fonds de recherche du Québec (FRQNT) for financial support (File#301734).
Nonlinear thermomechanical modeling of refractory masonry linings
Creators: name: ALI, Mahmoud
Publisher: name: Zenodo
Year: 2021

description: This work was supported by the funding scheme of the European Commission, Marie Skłodowska-
 Curie Actions Innovative Training Networks in the frame of the H2020 European project ATHOR
 - Advanced THermomechanical multiscale mOdelling of Refractory linings [grant number
 764987].
SOCIOLINGUISTICS AND LANGUAGE CHANGE:  FACTORS AND INFLUENCES TO THE EVOLUTION OF LANGUAGE
Creators: name: Noryigitova, Zarina
name: Khamidova, Durdona
Publisher: name: Zenodo
Year: 2025

description:   Language change is an ongoing process shaped by a range of sociolinguistic influences, such as ethnic identity, migration, and technological progress. This research examines the fluid nature of linguistic evolution, focusing on how social identity and language interaction contribute to the emergence of ethnolects and dialectal variations. Migration facilitates linguistic borrowing, code-switching, and structural modifications, while advancements in digital communication accelerate language transformation by introducing new vocabulary and informal grammatical patterns. The results indicate that both social and technological factors significantly impact language variation across different communities. By exploring these aspects, this study enhances our understanding of linguistic change and emphasizes the necessity for further research on how globalization and digital communication influence long-term language development.
title: Vergangene Zukunft? Der russisch-ukrainische Krieg und die Rückkehr der modernen Zeiterfahrung
Creators: name: Frysztacka, Clara M.
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Seit dem Einmarsch der russischen Truppen in die Ukraine überbieten sich die Prognosen über den Anbruch einer neuen (oder alten?) Zeit der Geopolitik. Es prägen die Sorgen des „Krieges in Europa“ beziehungsweise eines „Dritten Weltkrieges“, in dem sich die Kategorien des Westens und Ostens, der Demokratie und Diktatur (wieder) feindselig gegenüberstehen.
Die Bedrohungskulisse des Krieges suggeriert die Reaktivierung einer Zukunftsperspektive, die sich als genuin modern bezeichnen lässt: erstens und ganz banal, weil sich darin die moderne Geschichte des 19. und vor allem des 20. Jahrhunderts zu wiederholen scheint; zweitens aufgrund der wiedergewonnenen Bedeutung des historischen Ost-West-Konfliktes, die die bereits länger diskreditierte These eines postmodernen Endes der Geschichte nach 1989 endgültig archiviert; und schließlich, weil der Krieg einen Erwartungshorizont eröffnet, dessen Gestaltung allein in den Händen der Menschen – nicht Gottes, der Viren oder des Klimas – liegt und somit eine völlig menschliche „Machbarkeit“ der eigenen Geschichte voraussetzt. 
Erleben wir aber wirklich eine Rückkehr der Moderne oder wie können wir die Zeiterfahrung sonst begreifen, die durch den Diskurs über den Krieg gerade ausgelöst wird? Ich möchte hier einige Überlegungen über diese Fragen zusammentragen, die mich in den letzten Tagen und Wochen begleitet haben.
title: Dnipro oder Dnjepr? Über die Ortsnamen, die wir wählen, und die Folgen unserer Entscheidungen
Creators: name: Portnov, Andrii
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: Die moderne westliche Welt bekennt sich bewusst zu Toleranz, zur Achtung lokaler Stimmen, zur Demonstration der Ideale der Gleichheit, auch auf sprachlicher Ebene. Wichtige Elemente dieses Prozesses sind das konsequente ‘Gendering‘, die Betonung der Tatsache, dass der gewählte Begriff die Gruppenidentität nicht verletzt und keine koloniale Optik reproduziert. Wie sieht die deutsche Terminologie in diesem Zusammenhang in Bezug auf die Länder Osteuropas aus? In den folgenden Ausführungen geht es nicht um die Nationalisierung der Geschichte, sondern um die Gefahr von Doppelstandards bei der Wahl der Terminologie und die Bedeutung einer angemessenen Darstellung der historischen Vergangenheit und Gegenwart. Eine Darstellung, die allen historischen Akteuren Respekt zollt. Und die Komplexität der Geschichte Osteuropas vermitteln und nicht ausblenden will.
title: Too Close to Home. How Minority Communities Broaden the Scope of Care and Help
Creators: name: Nguyen Vu, Thuc Linh
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: As much as war is about armed military conflict, it is also fundamentally about mass displacement, broken lives, and lost futures. This simple truth has become way too obvious in large parts of Poland, where providing food, clothes and shelter to strangers, and collecting donations to help refugees from neighboring Ukraine have become common practices among “ordinary” people. Much of the efforts of this grassroots mass mobilization to help those escaping their war-torn country falls on the shoulders of various parts of society, including individual activists and non-activists as well as civil society organizations. 
What is perhaps less visible in this civil society mobilization and its media coverage are the efforts of migrant and minority communities that do their share in offering relief to those fleeing from Ukraine.
title: Medien in Russland. Von Unabhängigkeit zur Kontrolle
Creators: name: Khrushcheva, Daria
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: zdbooks
Year: 2024
Subjects: subject: 947 Geschichte Osteuropas; Russlands

description: "Politische Journalisten in Russland leben gefährlich" – schrieb die deutsche Journalistin Elke Windisch im Mai 2011. "Polemisiert und diskutiert wird nur noch im Internet, in Blogs und sozialen Netzwerken […]. Die Frage ist: Wie lange noch?" 
Einschränkungen der Pressefreiheit, Zensur und die strenge Kontrolle der Medien in Russland haben nicht erst im Zusammenhang mit dem Angriff auf die Ukraine und nicht einmal im Jahr 2014, nach der Annexion der Krim und dem Ausbruch des bewaffneten Konflikts in der Ostukraine, begonnen. Es reicht nur ein Blick auf die Entwicklung der russischen Medienlandschaft der letzten 20 oder gar 30 Jahre, um zu sehen: All dies begann wesentlich früher.