cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Electrical Heating Vest for Heart Failure and/or Hypertension Therapy
Creators: name: Meng, Fanqin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Thermal Therapy
Electrical Heating Vest
Heart Failure
Hypertension

description: Purpose: To develop a lightweight, safe, and controllable electrical heating vest for heart failure and/or hypertension patients. Methods: a. A literature review related to the topic was conducted. b. A model of a simplified human body thermoregulation system was developed and simulated. It was used to predict the power requirement of the battery to increase core body temperature up to 1 Celsius degree (°C). c. A prototype with a smart controller was developed d. In-vitro tests of the prototype were conducted to assess performance and safety. e. The prototype was tested on 10 healthy human volunteers and the results were analyzed. Results: a. An average core body temperature increase of 0.3 °C (P<0.05) was observed in healthy human volunteer tests within 30 minutes. b. The vest induced decreases in systolic blood pressure of 5.5 mmHg and diastolic blood pressure of 4.8 mmHg on average. Conclusions: A carbon-fiber vest can increase body core temperature by 0.3°C lowering systolic and diastolic blood pressure, which can be potentially used for helping heart failure and/or hypertension patients.
Living Inquiries Storyboard: A/r/tographic Artefact
Creators: name: Mallos, Melina
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 390101
subject: Creative arts, media and communication curriculum and pedagogy
classificationCode: 390401
subject: Comparative and cross-cultural education
classificationCode: 470212
subject: Multicultural, intercultural and cross-cultural studies

description: As the a/r/tographer leading this participatory research, my chosen method of rendering data throughout this dissertation was storyboarding. Each storyboard presents visual, metaphoric openings to contemplate my own identity and migration experience amidst the voices of my participants. The artmaking and participatory activities have woven their ways in and out of my thinking as a/r/tographer. Through reflection on our digital interactions, what evolved for each participant became more important to my praxis in depicting how my own living inquiry continued to grow and change throughout the research. By rendering the data through living inquiry, I created a storyboard combining some of the visual images, experiences, and sentiments articulated and expressed by the participants. In other words, the storyboard is an artefact of our living inquiries. The elements I included in the rendering below were to make sense of the data derived from elements of the participants’ living inquiries that resonated with mine, such as missing Greece like I would miss a friend who I craved to see and reconnect with. The cultural elements such as Greek dance, costumes, music, and language are aspects that Greek migrants of a diaspora seem to cling to or embrace while also creating a life in Australia, wearing different masks depending on the contexts. With COVID-19, this mask became not only a metaphorical, but also a physical marker of emotional and social distance and a barrier to intimacy or expressing the true self. In the storyboard, the different voices and perspectives were incorporated to describe a unifying or shared experience. I selected and assigned images to the concepts that the participants shared, which resonated with my own experiences, and organised them into a visual artefact.
Effect of Forming Process on the Deformational Behaviour of Steel Pipes
Creators: name: Tanbakuei Kashani, Majid
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Buckling strains
UOE forming process
Nonlinear hardening
Pipelines
Chaboche model
Buried pipeline behaviour
Plasticity
Pressurized and unpressurized pipes

description: Buried pipeline networks play a vital role in the transportation of oil and natural gas from centers of production to centers of consumption. A common manufacturing technique for such pipes is the UOE process, where a flat steel plate is first formed into a U shape, then into an O shape, welded at the seam, and mechanically expanded before being shipped on site. The UOE forming process deforms the pipe material plastically and induces residual strains in the pipe. Such pipes are commonly buried on side and then are pressurized under the high head of the fluids they convey which induce hoop stresses as high as 80% of the pipe yield strength. When buried pipelines cross the regions of discontinuous permafrost, they undergo differential frost heaving, inducing significant bending deformations, which potentially induce local buckling in the pipe wall. To control local buckling, design standards impose threshold limits on buckling strains. Such threshold values are primarily based on costly full-scale experimental results. Past nonlinear finite element analysis attempts aiming at determining the threshold buckling strains have neglected the presence of residual stresses induced by the UOE forming and were thus found to grossly overestimate the buckling strains compared to those based experiments. Within the above context, the present study focuses on developing a numerical technique to predict the residual stresses induced during UOE forming, and incorporating the induced residual stresses in 3D nonlinear FEA modeling to more reliably predict buckling strain limits. Comparisons with conventional analysis techniques that omit residual stresses reveal the importance of incorporating residual stresses induced in forming when quantifying buckling strains.
African Universities Performance Indicator Data: A MANUAL on Collecting Academic Programme, Student and Academic Staff Data
Creators: name: Bunting, I
Publisher: name: Zenodo
Year: 2014
Subjects: data
higher education
Africa
university

description: The major focuses of the Higher Education Research and Advocacy Network in Africa (HERANA) is a cross-national project focusing on developing performance indicators and developing the information-processing capacity of the participating
 universities. It was decided that in order to satisfy these aspects, the outputs of captured would have to be supported by the following: • definitions and descriptions of the use of the data concepts needed for performance measurement and for cross-national comparisons; and
 • examples of the use of the data for performance measurement within individual universities. This document is intended to serve as a manual which satisfies these two components.
description: Published by HERANA.
Lung Cancer Risks to Canadians from Residential Radon Exposure
Creators: name: Corrigan, Robin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: radon
exposure
lung
cancer
Canada
radiation
residential
residence

description: A causal link between radon exposure and lung cancer was previously established through numerous epidemiological studies of miners and residential occupants exposed to radon gas. Although the health detriment to Canadians from residential radon exposure has been estimated in earlier assessments, a comprehensive radon survey by Health Canada in 2011 was the first to sample residences from every health region in the country. Further, this survey yielded higher concentration measurements than previous surveys, with an arithmetic average concentration about twice that of an older survey which was the basis for many of the previous Canadian radon risk assessments. Two exposure-response models from the US NRC were selected for this thesis, along with seasonal adjustment factors for the survey data to compute expected value, rather than conservative, risk estimates. Population-based (population attributable risk, PAR; excess lifetime risk ratio, ELRR; and life-years lost LYL) and individual-based (ELRR and LYL) indices are used to summarize the health detriment. Mean estimates of ELRR, PAR, and LYL for the Canadian population are estimated in the range of 0.31 - 0.48, 0.19 - 0.26, and 0.19 - 0.31, respectively, depending on the model used. Point estimates are also provided for individual provinces and some results are strati ed by risk factors, such as smoking history and floor level of residency. A number of sources of uncertainty in the results are identified, and some are incorporated in a two-dimensional uncertainty analysis using Monte Carlo methods.
Deposition ice nucleation on soot at temperatures relevant for the lower troposphere.
Creators: name: Dymarska, Magdalena
name: Murray, Benjamin J.
name: Sun, Lumin
name: Eastwood, Michael L.
name: Knopf, Daniel A.
name: Bertram, Allan K.
Publisher: name: American Geophysical Union
Year: 2016

description: The ice nucleating efficiency of many important atmospheric particles remains poorly understood. Here we investigate the ice nucleation properties of a range of soot types including soot that has been treated with atmospherically relevant amounts of ozone. We focus on deposition nucleation below water saturation and at temperatures ranging from 243 to 258 K. For our experimental conditions, ice nucleation never occurred at temperatures above 248 K and below water saturation. Below 248 K, ice occasionally formed in our experiments with no indication of the formation of water droplets prior to ice formation. However, even at these temperatures the relative humidity with respect to ice (RHi) was close to water saturation when ice nucleation was observed, suggesting water nucleation may have occurred first followed by ice nucleation during the condensation process. We also performed a complimentary set of experiments where we held soot particles at 248 K and RHi = 124 ± 4%, which is just below water saturation, for a period of 8 hours. From these measurements we calculated an upper limit of the heterogeneous ice nucleation rate coefficient of 0.1 cm−2 s−1. If the number of soot particles is 1.5 × 105 L−1 in the atmosphere (which corresponds to urban‐influenced rural areas), then the number of ice particles produced below water saturation at these conditions is at most 0.1 particles L−1 on the basis of our upper limit. We conclude from our studies that deposition nucleation of ice on most types of soot particles is not important in the Earth's troposphere above 243 K and below water saturation. An edited version of this paper was published by AGU. Copyright 2006 American Geophysical Union.
Comparison of Odds Ratios in AERS
Creators: name: Hoekstra, Rinke
Publisher: name: figshare
Year: 2012
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: This is a report on running some tests against AERS-LD -- a linked data version of the Adverse Event Reporting System of the FDA - inspired by Katoyama et al. (2011)
An Investigation of Low Temperature Direct Propane Fuel Cells
Creators: name: Parackal, Bhavana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Direct Propane Fuel Cell
CFD Modeling Parametric Study
FreeFem++
Finite element numerical method
Nafion MEA
Bubble Humidifier
Liquid water interdigitated flow field
Oscillations
Pin-type flow field
Anode humidification

description: This research is directed toward the investigation of a low temperature direct propane fuel cell (DPFC). Modeling included a parametric study of a direct propane fuel cell using computational fluid dynamics (CFD), specifically FreeFem++ software. Polarization curves predicted by the CFD model were used to understand fuel cell performance. The predictions obtained from the computational fluid dynamics mathematical model for the fuel cell were compared with experimental results. The computational work identified some critical parameters (exchange current density, pressure, temperature) for improving the overall performance of the fuel cell. The model predictions clearly highlighted the role of catalysts in significantly enhancing the overall performance of a DPFC. Experiments were performed using commercial Nafion-Pt based membrane electrode assemblies (MEAs) to obtain a basis for comparison. It is the first report in the literature that a Pt-Ru (Platinum-Ruthenium) MEA was used in the investigation of a DPFC. Also, it was the first study that fed liquid water continuously to a DPFC by using interdigitated flow field (IDFF) at the anode to humidify the dry propane feed gas. During the experiments oscillations were observed at very low current densities i.e. in nA/cm2, which is a rare case and not reported in the literature to date. This observation has raised serious concerns about the existence of absolute open-circuit cell potential difference for a DPFC. The cycling behaviour observed with DPFC indicated the presence of a continuous degradation-regeneration process of the catalyst surface near open-circuit potential. The experimental work further evaluated the performance of fuel cell by measurement of polarization curves.
On the Origin of Secosterols Upon Oxidation of Cholesterol
Creators: name: Zopyrus, Nadia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Autoxidation
Lipid peroxidation
Secosterols
ROS

description: Cholesterol is one of the most abundant lipids in the body, and like all unsaturated lipids, it can be oxidized by a variety of reactive oxygen species (ROS). Lipid peroxidation is one of the main pathways by which ROS induce oxidative damage, and has been linked to neurodegenerative and cardiovascular diseases. In 2003, Wentworth et al. detected both 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol-A) and its intramolecular aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (secosterol-B) in human atherosclerotic plaques – compounds which, at the time, were only known to be formed by cholesterol ozonolysis. However, our group has shown that cholesterol 5α-hydroperoxide, which is the product of the reaction of cholesterol with singlet oxygen, can undergo acid-catalyzed Hock fragmentation to generate secosterol-A and -B as well. Nevertheless, cholesterol 5α-hydroperoxide readily rearranges to a more thermodynamically stable cholesterol 7-hydroperoxide. Herein we show that cholesterol 7-hydroperoxide, the main product of cholesterol autoxidation, can also undergo acid-catalyzed Hock fragmentation that gives rise to electrophilic species with similar chromatographic characteristics to those that were allegedly identified as secosterol-A and -B. We also proposed to prepare authentic products of the Hock fragmentation of cholesterol 7-hydroperoxide by subjecting Δ⁶’⁷-cholesterol to ozonolysis. Herein, we explore the limitations and complications of Δ⁶’⁷-cholesterol ozonolysis as well as cholesterol 7-OOH Hock fragmentation which both resulted in unexpected (unprecedented) products.
Targeting the Process of c-MYC Stabilization in Chronic Myelogenous Leukemia
Creators: name: Sunohara, Maxwell
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: c-MYC
leukemia
OGT
Chronic Myelogenous Leukemia

description: Currently there is no curative therapy for Chronic Myelogenous Leukemia (CML), and patients must remain on the current prescribed treatment, tyrosine kinase inhibitors (TKI), indefinitely. Although many patients can survive in the chronic phase of the disease under TKI treatment, some patients do progress to the terminal blast crisis phase of the disease. Patients in this terminal phase do not respond to TKI treatment. We evaluated the therapeutic benefit of targeting the oncogene c-MYC in CML, using the CML cell line K562. This was achieved by inhibiting the enzyme O-linked β-N-acetylglucosamine Transferase (OGT), using two indirect inhibitors 2-deoxyglucose and Azaserine, and the direct inhibitor ST078925. Treatment with these inhibitors resulted in decreased half-life of c-MYC protein in K562, reduced c-MYC protein in K562 cells, and reduced K562 cell growth. Together these results suggest that targeting c-MYC through OGT may be a potential therapeutic option for patients with CML.
Gender and post-ischemic recovery of hypertrophied rat hearts
Creators: name: Saeedi, Ramesh
name: Wambolt, Richard B
name: Parsons, Hannah
name: Antler, Christine
name: Leong, Hon S
name: Keller, Angelica
name: Dunaway, George A
name: Popov, Kirill M
name: Allard, Michael F
Publisher: name: BioMed Central
Year: 2016

description: Background: Gender influences the cardiac response to prolonged increases in workload, with differences at structural, functional, and molecular levels. However, it is unknown if post-ischemic function or metabolism of female hypertrophied hearts differ from male hypertrophied hearts. Thus, we tested the hypothesis that gender influences post-ischemic function of pressure-overload hypertrophied hearts and determined if the effect of gender on post-ischemic outcome could be explained by differences in metabolism, especially the catabolic fate of glucose. Methods: Function and metabolism of isolated working hearts from sham-operated and aortic-constricted male and female Sprague-Dawley rats before and after 20 min of no-flow ischemia (N = 17 to 27 per group) were compared. Parallel series of hearts were perfused with Krebs-Henseleit solution containing 5.5 mM [5-3H/U-14C]-glucose, 1.2 mM [1-14C]-palmitate, 0.5 mM [U-14C]-lactate, and 100 mU/L insulin to measure glycolysis and glucose oxidation in one series and oxidation of palmitate and lactate in the second. Statistical analysis was performed using two-way analysis of variance. The sequential rejective Bonferroni procedure was used to correct for multiple comparisons and tests. Results: Female gender negatively influenced post-ischemic function of non-hypertrophied hearts, but did not significantly influence function of hypertrophied hearts after ischemia such that mass-corrected hypertrophied heart function did not differ between genders. Before ischemia, glycolysis was accelerated in hypertrophied hearts, but to a greater extent in males, and did not differ between male and female non-hypertrophied hearts. Glycolysis fell in all groups after ischemia, except in non-hypertrophied female hearts, with the reduction in glycolysis after ischemia being greatest in males. Post-ischemic glycolytic rates were, therefore, similarly accelerated in hypertrophied male and female hearts and higher in female than male non-hypertrophied hearts. Glucose oxidation was lower in female than male hearts and was unaffected by hypertrophy or ischemia. Consequently, non-oxidative catabolism of glucose after ischemia was lowest in male non-hypertrophied hearts and comparably elevated in hypertrophied hearts of both sexes. These differences in non-oxidative glucose catabolism were inversely related to post-ischemic functional recovery. Conclusion: Gender does not significantly influence post-ischemic function of hypertrophied hearts, even though female sex is detrimental to post-ischemic function in non-hypertrophied hearts. Differences in glucose catabolism may contribute to hypertrophy-induced and gender-related differences in post-ischemic function.
Naturewatch Canada: Metadata Analysis for a Citizen-Science Based Monitoring Program
Creators: name: L'Ecuyer, François
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: citizen_science
environment

description: NatureWatch Canada, a citizen science program, collects and analyses data pertaining to plant phenology, frog species and ice coverage over water bodies in Canada to monitor trends through time and space in relation to climate change. An important question is whether this database is currently usable to infer environmental changes through space and time. This thesis presents a metadata analysis of the Nature Watch database in order to identify the spatial validity, quality, reliability and usability of the current data. We first explore citizen science through a review of the literature, followed by a detailed analysis of the content of the database. We also produce an example Newsletter for each module to illustrate some of the current trends in the data. The Frogwatch Newsletter shows how weather conditions in 2001 may have favored a population spurt of Leopard frogs resulting from more spawning ponds essential for this species. Next the Plantwatch Newsletter reveals that an increase in Aspen poplar and Prairie crocus in 2002 may have been due to fires during the preceding years. Lastly, the Icewatch Newsletter shows how ice formation, but not melt, reveals a clear trend of occurring 17 days later over the last 100 years with a stronger increase starting in the sixties for Western Ontario. In summary, this thesis presents a detailed metadata analysis of the Naturewatch database in order to provide recommendations for its improvement in the future. Improving programs like Naturewatch Canada is important to monitoring climate and ecological changes that could be applied throughout the Canadian North which are not currently well represented in this database.
Development and Validation of a Multivariable Prediction Model for All-Cause Cancer Incidence Based on Health Behaviours in the Population Setting
Creators: name: Maskerine, Courtney
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: prediction
cancer
population health
health behaviours

description: Background: We examined if it was possible to use routinely available, self-reported data on health behaviours to predict incident cancer cases in the Ontario population. Methods: This retrospective cohort study involved 43 696 female and 36 630 male respondents from Ontario, who were >20 years old and without a prior history of cancer, to the Canadian Community Health Survey (CCHS) cycles 2.1-4.1. The outcome of interest was malignant cancer from any site, termed all-cause cancer, determined from the Ontario Cancer Registry. Predictor variables in the risk algorithm were health behaviours including smoking status, pack-years of smoking, alcohol consumption, fruit and vegetable consumption and physical activity level. A competing-risk Cox proportional hazard model was utilized to determine hazard of incident cancer. The developed risk prediction tool was validated in the CCHS cycle 1.1 on 14 426 female and 11 970 male survey respondents. Results: Incident cancer was predicted with a high degree of calibration (differences between observed and predicted values for females 2.97%, for males 4.23%) and discrimination (C-statistic: females 0.76, males 0.83). Similar results were obtained in the validation cohort. Conclusions: Routinely collected self-reported information on health behaviours can be used to predict incident cancer in the Ontario population. This type of risk prediction tool is valuable for public health purposes of estimating population risk of incident cancer, as well as projection of future risk in the population over time.
Experimental Modal Analysis using Ambient and Earthquake Vibrations: Theory, Software, Applications.
Creators: name: Ntotsios, Evangelos
Publisher: name: figshare
Year: 2012
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: PhD Thesis. Submitted to the Department of Mechanical Engineering, University of Thessaly. Deffended December 2009. Division of Mechanics, Materials & Manufacturing Processes, System Dynamics Laboratory. In English.
Pleistocene and Holocene Climate Reconstruction at Two Moose Lake, Central Yukon, Using Stable Isotopes and 14C-DOC Radiocarbon from Ice wedges, Pore Ice and Buried Sediments
Creators: name: Grinter, Michael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Ice Wedges
Paleoclimate
Stable Isotopes
Yukon
Radiocarbon
AMS
Buried Ice
Glaciation
DOC
Quaternary
Holocene
Pleistocene

description: The objective of this thesis was to reconstruct the Sedimentary, Cryostratigraphic and Paleoclimatic history of Two Moose Lake, central Yukon using a new analytical technique for dating ice wedges using Dissolved Organic Carbon (DOC). During two field seasons in August 2013 and April 2014, 442 samples were collected from a newly exposed headwall of a thaw slump with 7 ice wedges and over 4m of sediment. Using cryostratigraphy, granulometry, stable isotopes and 18 14C-DOC ages, 4 stratigraphic units were delineated: 1) a sediment-rich ice layer inferred to be of glacial origin (>32ka BP); 2) a silt-rich layer deposited during the Holocene Thermal Maximum (~10 to 8.2ka BP); 3) a silt with organics layer deposited from ~8ka to 6.4ka BP, and 4) a paleo-active layer and modern active layer. 14C-DOC dating indicated two periods of ice wedge activity at Two Moose Lake, the first during the late Pleistocene (31,608 to 12,990 yr cal BP) and from the mid-Holocene to present (6,328 to 892 yr cal BP). The presence of late-Pleistocene aged ice wedges at Two Moose Lake supports the common belief of an unglaciated central Yukon during the most recent McConnell glaciation from 29.6 to 13ka BP. Values for δ18O from the Holocene- and Pleistocene-aged ice wedges were 2-3‰ and 5-9‰ depleted compared those of modern precipitation from Mayo (-22.32‰). Medium-resolution (2-4cm) sampling along with multiple 14C-DOC samples along a transect allowed for the creation of a continuous δ18O and temperature age profile to be developed from multiple ice wedges, showing a strong consistency between overlapping ages. The reconstruction of the paleoclimate of Two Moose lake is consistent with known events from southern Yukon including the Boutellier Inderstadial, a cold unglaciated central Yukon during the McConnell Glaciation, warming during the Holocene Thermal Maximum (HTM) followed by an extreme cooling event at 8.2ka BP, a cooling event at 4.2ka BP, and the subsequent warming to present temperatures.
Methods for identifying models of complex structures using information from measured vibrations.
Creators: name: Ntotsios, Evangelos
Publisher: name: figshare
Year: 2012
Subjects: subject: Mechanics
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: PhD Thesis. Submitted to the Department of Mechanical Engineering, University of Thessaly. Deffended December 2009. Division of Mechanics, Materials & Manufacturing Processes, System Dynamics Laboratory. In English.
Controllable Natural Language Generation
Creators: name: Wang, Yufei
Publisher: name: Macquarie University
Year: 2024
Subjects: classificationCode: 399999
subject: Other education not elsewhere classified

description: In this thesis, various methods are explored to control the textual content of autoregressive neural language generators as used in several Natural Language Generation tasks, including Novel Object Captioning, Commonsense Generation, Story Generation, Machine Translation and Data Augmentation, in entity and sentence levels. The aim is to develop neural language generators that produce fluent natural language output while meeting various task-specific requirements. The significant contributions of this thesis are the following:• Reinforcement learning is used to encourage novel object captioning systems to mention salient visual objects in the input images. (Published in EACL 2021)• An approach called Mention Flags is developed, which generalises the Transformer Attention mechanism in a way that permits to control the entities mention. (Published in ACL 2021)• Mention Flags are generalised to the Neural Rule-Execution Tracking Machine, which can incorporate a wide range of lexical constraints and task-specific prior knowledge. (Published in NeurIPS 2021)• Soft Prompt Neural Text Generators are applied to generate high-quality and diverse training examples for various NLU tasks under the low-resource setting. (Published in ACL 2022)From the acquired experimental results, it is demonstrated that the proposed methods outperform a wide range of competitive baselines and a new state-of-the-art on a wide range of tasks is set.
Ole Döring: Technischer Fortschritt und kulturelle Werte in China. Humangenetik und Ethik in Taiwan, Hongkong und der Volksrepublik China
Creators: name: Roetz, Heiner
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 69 (1998): ASIEN (Oktober)
Additional file 1 of Targeted imaging of orthotopic prostate cancer by using clinical transformable photoacoustic molecular probe
Creators: name: Qiu, Chen
name: Yuanyuan Bai
name: Tinghui Yin
name: Xiaoyan Miao
name: Rongkang Gao
name: Huichao Zhou
name: Ren, Jie
name: Song, Liang
name: Chengbo Liu
name: Hairong Zheng
name: Rongqin Zheng
Publisher: name: figshare
Year: 2020
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Cancer

description: Additional file 1: Figure S1. Modeling of rats with orthotopic prostate cancer. A. Ultrasound images. B. General observation. Blue arrow: bladder. Yellow arrow: tumor. C. Observation under the microscope. Black arrow: prostate gland. Red arrow: cancerous tissue. (Magnitude: 50 ×). Figure S2. Pathology including both H&E staining and immunochemistry staining of both prostate gland and tumor tissue. (Magnitude: 100 ×). Figure S3. Representative PA map images of rats with orthotopic PCa.
Virtual Machine Management for Dynamic Vehicular Clouds
Creators: name: Refaat, Tarek
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Vehicular Cloud
Virtual Machine Migration
Optimization

description: Vehicular clouds involve a dynamic environment where virtual machines are hosted on moving vehicles, leading to frequent changes in the data center network topology. These frequent topological changes require frequent virtual machine migrations in order to meet the service level agreements with cloud users. Such topology changes include fluctuations in connectivity, signal strength and quality. Few studies address vehicles as potential virtual machine hosts, while there is a significant opportunity in capitalizing on underutilized resources. Due to the rapidly changing environment of a vehicular cloud, hosts frequently change or leave coverage. As such, virtual machine management and migration schemes are necessary to ensure cloud subscribers have a satisfactory level of access to the resources. This thesis addresses the need for virtual machine management for the vehicular cloud. First, a mobility model is proposed and utilized to test a set of novel Vehicular Virtual Machine Migration (VVMM) schemes: VVMM-U (Uniform), VVMM-LW (Least Workload), VVMM-MA (Mobility Aware) and MDWLAM (Mobility and Destination Workload Aware Migration). Their performance is evaluated with respect to a set of metrics through simulations with varying levels of vehicular traffic congestion, virtual machine sizes and load restriction levels. The most advanced scheme (MDWLAM) takes into account the workload and mobility of the original host as well as those of the potential destinations. By doing so a valid destination will both have time to receive the workload and migrate the new load when necessary. The behavior of various algorithms is compared and the MDWLAM has been shown to demonstrate the best performance, exhibiting migration drop rates that are negligibly small. Finally, an integer linear program formulation based on a modified single source shortest path problem is presented, tested and successfully shown to be a benchmark that can be used in comparison to the proposed heuristics.
FoxO3a Signaling Promotes the Inflammatory Response During Salmonella Typhimurium Infection
Creators: name: Ametepe, Sandra Emmanuelle
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: FoxO3a
Salmonella
Inflammation

description: FoxO3a is a transcription factor that regulates various cellular functions such as cell cycle or cell death. However, its role in the innate immune response is not clear. I investigated the impact of FoxO3a signaling on the immune response during infection with Salmonella Typhimurium (ST). My results revealed that FoxO3a regulated the homeostasis of myeloid cells in the spleen and blood of mice during steady-state. Following infection of macrophages with ST, FoxO3a signaling promoted the expression of pro-inflammatory cytokines such as IL12 and TNFα, but inhibited the expression of the anti-inflammatory cytokine IL10. Phenotypic analysis revealed that FoxO3a signaling had no effect on classical macrophage polarization into M1 vs M2 phenotypes, although it appeared to regulate mitochondrial function during infection with ST. Inflammatory responses are critical during infection with virulent intracellular pathogens, and these results provide new insights into the role of FoxO3a signaling in inflammatory responses.
Morphodynamic Modelling of Sediment Control Groynes in a Meandering River Entering a Reservoir
Creators: name: Mohammed, Zhina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Meandering
Morphology
Groynes
Delft3d
Reservoir

description: Sedimentation is one of the consequences of hydropower plant construction. Such structures not only have an influence on reservoir morphology, but also have great impact on both upstream and downstream river morphology. This study focuses on fluvial morphological changes in between two hydropower plants on the Drava River, Austria. The influence of both reservoir management methods (flushing) and human intervention (groynes) have been investigated. The first stage started with validating an unsteady Delft3D morphodynamic model of the meandering reach. This validation shows the importance of spatial grain size distribution in predicting bed load transport. Analysis of the flushing method includes investigation of the duration of gate-opening before and after peak flood. The results show that the duration of lowering the water level at the hydropower plant (by opening the gate) before starting the peak flood will not have a big influence on the river morphology upstream of the reservoir. However, the duration of maintaining the low water level after the peak flood has a large influence on both the river morphology in the upstream portion of the reservoir and on the sediment transport toward the reservoir In the second part of this study, hydraulic structural groynes were applied in the river reach. The objective was to design a groyne field that will minimize sediment transport to the reservoir. Both emerged and submerged groynes were investigated. In addition, the influences of both groyne head shape and the distribution of sediment grain size in the groyne zone were examined. This study shows that under an unsteady simulation, when the groynes are submerged by 1m at normal flow, the sediment supply to the groyne zone decreases compared to the emerged case. However, if the groynes are submerged by 0.5m, the sediment supply to the groyne zone will be greater than the emerged case for an aspect ratio in between (0.5-2). Finally, applying L-head groynes produces less erosion in the main stream and a higher sediment supply compared to straight groynes.
Influence of extrinsic factors on the conformational dynamics of industrially important proteins: A molecular perspective
Creators: name: Sundaram, Vidya
Publisher: name: Monash University
Year: 2021
Subjects: classificationCode: 300199
subject: Agricultural biotechnology not elsewhere classified
classificationCode: 320699
subject: Medical biotechnology not elsewhere classified
classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified

description: Proteins are inherently dynamic molecules that require a stable structure to execute their biological functions. Variations in extrinsic factors such as temperature, pH, and solution conditions can induce structural changes in proteins that favor or negatively affect a protein’s functions. Interpreting the molecular basis of the structural changes of proteins would significantly accelerate the development of stable protein formulations for industrial applications. This thesis highlights the insights gained from the molecular dynamics simulations of two model proteins, which will further the understanding of the interplay between protein structure and dynamics.
Psychosocial and other working conditions in relation to body mass index in a representative sample of Australian workers
Creators: name: Ostry, Aleck S.
name: Radi, Samia
name: Louie, Amber M
name: LaMontagne, Anthony D
Publisher: name: BioMed Central
Year: 2016

description: Background: The aim of the study was to examine the relationship between psychosocial and other working conditions and body-mass index (BMI) in a working population. This study contributes to the approximately dozen investigations of job stress, which have demonstrated mixed positive and negative results in relation to obesity, overweight and BMI. Methods: A cross-sectional population-based survey was conducted among working Australians in the state of Victoria. Participants were contacted by telephone from a random sample of phone book listings. Information on body mass index was self-reported as were psychosocial work conditions assessed using the demand/control and effort/reward imbalance models. Other working conditions measured included working hours, shift work, and physical demand. Separate linear regression analyses were undertaken for males and females, with adjustment for potential confounders. Results: A total of 1101 interviews (526 men and 575 women) were completed. Multivariate models (adjusted for socio-demographics) demonstrated no associations between job strain, as measured using the demand/control model, or ERI using the effort/reward imbalance model (after further adjustment for over commitment) and BMI among men and women. Multivariate models demonstrated a negative association between low reward and BMI among women. Among men, multivariate models demonstrated positive associations between high effort, high psychological demand, long working hours and BMI and a negative association between high physical demand and BMI. After controlling for the effort/reward imbalance or the demand/control model, the association between physical demand and working longer hours and BMI remained. Conclusion: Among men and women the were differing patterns of both exposures to psychosocial working conditions and associations with BMI. Among men, working long hours was positively associated with higher BMI and this association was partly independent of job stress. Among men physical demand was negatively associated with BMI and this association was independent of job stress.
Storyboard: Contiguity, computer-generated
Creators: name: Mallos, Melina
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 390101
subject: Creative arts, media and communication curriculum and pedagogy
classificationCode: 390401
subject: Comparative and cross-cultural education
classificationCode: 390410
subject: Multicultural education (excl. Aboriginal and Torres Strait Islander, Māori and Pacific Peoples)

description: The Contiguity Storyboard represents elements from each of the eight study participants’ identities – elements I chose because they resonated with mine. The storyboard reflects these complex meanings but is also an example of doubling in its combination of text and images supplied by the participants. The participants’ social media behaviours incorporated into the storyboard include: scrolling through a social media feed (observing); posting a photograph (interestingly, there were no selfies included); the beach; an outdoor concert and festival; a Greek flag; the words kind, experiences, social, and driven in the sky; and the two-fingered pose prevalent in photographs of youths uploaded to social media. In this storyboard, we see the capabilities of artist, researcher and teacher being brought together through image and text, process and product.
Climate Change Discourse in the Blogosphere
Creators: name: Pond, Abby
Publisher: name: figshare
Year: 2012
Subjects: subject: Environmental Science
subject: Sociology
subject: FOS: Sociology

description: This is a roughly formatted copy of my submitted dissertation for MSc in Climate Change Management, Birkbeck College, London, UK. Full title: Climate Change Discourse in the Blogosphere: a thematic exploration of online discourse, January—March 2012. Be gentle, I'm new to this. :) All feedback and questions welcome. See the project blog at climatediscourse.wordpress.com. Abstract: There has been much debate recently, in public and academic discourse, about how climate science and climate change issues are communicated. In this study, online discourse on climate change issues was examined with blogs as a focus. Thematic, inductive discourse analysis was undertaken on blog posts by 40 authors between 1 January and 1 March 2012. Ten initial themes were then developed into five frameworks and common discourses. This study discusses how blogging sits within greater climate discourse and possible reasons for the themes and discourses that have emerged, as well as areas for future research.
Preventing Childhood Drownings in Backyard, Residential Pools: Understanding Stakeholders' Roles in Knowledge Mobilization and the Creation of a 2017 Protable Pool Safety Social Marketing Campaign in Ottawa, ON
Creators: name: Valentino, Kylie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: subject: Drowning
subject: Marketing
subject: FOS: Economics and business
subject: Pool
subject: Legislation

description: In this first manuscript, the research purpose was to explore stakeholders perceived roles in mobilizing pool safety knowledge and to understand the barriers associated with the uptake of pool safety initiatives. Six water safety experts were interviewed to gain insight into their perceptions and diverse roles. Using grounded theory, it was determined that stakeholders perceive they have a role in mobilizing pool safety knowledge. Three overarching themes emerged from the data which aligned with a proposed Drowning Prevention Spectrum: pool safety experts perceive their responsibility in mobilizing pool safety knowledge through their role in developing knowledge and skills as a safety educator; developing and promoting campaigns and products through their role as a marketer of behaviour change; and through their role in the development and enforcement of policies and legislation. Interviewees were also asked what they perceived as some of the major barriers to the uptake of pool safety information and initiatives. Interviewed stakeholders revealed that the main social ecological barriers included personal barriers (cost and time), social barriers (policy and awareness), and physical barriers (backyard aesthetics). The results of the first manuscript demonstrates that even though all interviewed stakeholders perceive they have a role in mobilizing pool safety knowledge, there are still barriers in the uptake of pool safety knowledge by citizens and pool owners. The second manuscript focused on using Weinreich’s (2010) process model and semi structured interviews with six pool safety experts as well as marketing experts to create a social marketing campaign to emphasize the risks associated with portable pools. This article goes through the six steps outlined by Weinreich (2010) as well as using theories in the development of the campaign messages. Through interviews, experts gave their opinions and suggestions on most effective campaign messages, images, target audience, and promotional channels. The mock campaign ads were then presented to the marketing team in whom they gave their ideas and suggestions on how to hook the target audience in wanting to learn more about portable pool safety. A final campaign was crafted and will be implemented in a future City of Ottawa initiative.
Contiguity Storyboard: A/r/tographic Artefact
Creators: name: Mallos, Melina
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 390101
subject: Creative arts, media and communication curriculum and pedagogy
classificationCode: 390401
subject: Comparative and cross-cultural education
classificationCode: 390410
subject: Multicultural education (excl. Aboriginal and Torres Strait Islander, Māori and Pacific Peoples)

description: The Contiguity Storyboard represents elements from each of the eight study participants’ identities – elements I chose because they resonated with mine. The storyboard reflects these complex meanings but is also an example of doubling in its combination of text and images supplied by the participants. The participants’ social media behaviours incorporated into the storyboard include: scrolling through a social media feed (observing); posting a photograph (interestingly, there were no selfies included); the beach; an outdoor concert and festival; a Greek flag; the words kind, experiences, social, and driven in the sky; and the two-fingered pose prevalent in photographs of youths uploaded to social media. In this storyboard, we see the capabilities of artist, researcher and teacher being brought together through image and text, process and product.
Essentials Of The Theory Of Abstraction - Lecture
Creators: name: Ganguly, Subhajit
Publisher: name: figshare
Year: 2012
Subjects: subject: Quantum Mechanics
subject: 20203 Particle Physics
subject: FOS: Physical sciences
subject: Cosmology
subject: Condensed Matter Physics
subject: Computational Physics
subject: Atomic Physics
subject: Astrophysics

description: In not favouring solutions or sets of solutions, the principle of zero-postulation drives away any unwanted incompleteness from the description of the world. It is the interactions between the possible exhaustive set of solutions that creates the impression pointedness or directiveness in the universe, leading to the formation of clusters, as discussed earlier. These interactions may be chaotic in nature, giving rise to attractor points where the directiveness inside any given system asymptotically seem to approach. It is this directiveness, in turn, inside a given system or in the universe as a whole, that is the cause of all known phenomena. This directiveness of possibilities saves the universe from being exactly the same throughout, but makes it heterogeneously active, as we see it to be.