cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On the chirality of the SM and the fermion content of GUTs
Creators: name: Fonseca, Renato M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Standard Model (SM) is a chiral theory, where right- and left-handed fermion fields transform differently under the gauge group. Extra fermions, if they do exist, need to be heavy otherwise they would have already been observed. With no complex mechanisms at work, such as confining interactions or extra-dimensions, this can only be achieved if every extra right-handed fermion comes paired with a left-handed one transforming in the same way under the Standard Model gauge group, otherwise the new states would only get a mass after electroweak symmetry breaking, which would necessarily be small ($\sim100\textrm{ GeV}$). Such a simple requirement severely constrains the fermion content of Grand Unified Theories (GUTs). It is known for example that three copies of the representations $\mathbf{\overline{5}}+\mathbf{10}$ of $SU(5)$ or three copies of the $\mathbf{16}$ of $SO(10)$ can reproduce the Standard Model's chirality, but how unique are these arrangements? In a systematic way, this paper looks at the possibility of having non-standard mixtures of fermion GUT representations yielding the correct Standard Model chirality. Family unification is possible with large special unitary groups --- for example, the $\mathbf{171}$ representation of $SU(19)$ may decompose as $3\left(\mathbf{16}\right)+\mathbf{120}+3\left(\mathbf{1}\right)$ under $SO(10)$.
description: Minor changes; matches publication in Nuclear Physics B
Calculations for the Climate Equity Reference Calculator (CERc)
Creators: name: Kemp-Benedict, Eric
name: Athanasiou, Tom
name: Baer, Paul
name: Holz, Ceecee
name: Kartha, Sivan
Publisher: name: Zenodo
Year: 2018
Subjects: UNFCCC, climate, inequality, GHG emissions, equity, effort-sharing, mitigation, lognormal

description: The Climate Equity Reference Project (CERP) framework allocates responsibility for greenhouse gas
 mitigation and adaptation based on individual responsibility for historical emissions and capacity to act.
 The Climate Equity Reference Calculator (CERc) is a web-based tool for exploring how specic quan-
 titative expressions of the CERP framework aect allocations. This paper documents the calculations
 that the calculator implements.
Alkaloids of Adhatoda vasica Nees. as potential inhibitors of cyclooxygenases – an in-silico study
Creators: name: Ghanta, Prasanth
name: Doble, Mukesh
name: Ramaiah, Basavaraju
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Eicosanoid pathways play a crucial role in the progression and resolution of inflammation. NSAIDs act as anti-inflammatory agents by inhibiting both the isoforms of cyclooxygenases (COXs) whereas, COXIBs act as specific COX-2 inhibitors. Excessive usage of the same is linked with gastrointestinal bleeding and increased cardiovascular risk, respectively. The current in-silico study was aimed at evaluating the potential of major alkaloids of A. vasica (vasicine (VAS), vasicinone (VAE), and Deoxyvasicine (DOV)) as inhibitors of COXs. The results of the computed binding energy (ΔG) indicate that Celecoxib (CEL), DOV, and VAS have a higher affinity to COX-2, while VAE has a higher affinity to COX-1, and Mefenamic acid (MEF) was not selective. Among the alkaloids, VAE exhibited the best ΔG (of −8.2 kcal/mol) with COX-1, while VAS exhibited the best ΔG (of −8.2 kcal/mol) with COX-2. This was comparable to the ΔG exhibited by Mefenamic acid (-8.7 kcal/mol with both the COXs). With their potential to remain gastroprotective while having the ability to inhibit enzymes of both the prostaglandin and leukotriene pathways, the alkaloids of A. vasica could be promising leads for the design of Eicosanoid pathway modulators/inhibitors. Communicated by Ramaswamy H. Sarma
Basic Vector Map of Europe
Creators: name: von Felten, Jonas
Publisher: name: Zenodo
Year: 2019
Subjects: map
europe
qgis
layer

description: Basic vector map of Europe, the Isohypses are produced by using Copernicus data and information funded by the European Union - EU-DEM layers. The bodies of water are based on data from naturalearthdata.com.
description: {"references": ["https://www.eea.europa.eu/data-and-maps/data/eu-dem#tab-european-data", "http://www.naturalearthdata.com/"]}
The quest for collapsed/frozen stars in single-line spectroscopic binary systems
Creators: name: Trimble, Virginia
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Black holes are now commonplace, among the stars, in Galactic centers, and perhaps other places. But within living memory, their very existence was doubted by many, and few chose to look for them. Zeldovich and Guseinov were first, followed by Trimble and Thorne, using a method that would have identified HDE 226868 as a plausible candidate, if it had been in the 1968 catalogue of spectroscopic binaries. That it was not arose from an unhappy accident in the observing program of Daniel M. Popper long before the discovery of X-ray binaries and the identification of Cygnus X-1 with that hot, massive star and its collapsed companion.
description: Key Words: Black holes, collapsed stars, Cygnus X-1, HDE 226868, spectroscopic binaries Journal: The Zeldovich Universe Genesis and Growth of the Cosmic Web IAU Symposium 308, 23-28 June 2014, Tallinn, Estonia) http://iau.maido.ee/proceedings
CCAT: A status update on the EoR-Spec instrument module for Prime-Cam
Creators: name: Freundt, Rodrigo
name: Li, Yaqiong
name: Henke, Doug
name: Austermann, Jason
name: Burgoyne, James R.
name: Chapman, Scott
name: Choi, Steve K.
name: Duell, Cody J.
name: Huber, Zach
name: Niemack, Michael
name: Nikola, Thomas
name: Lin, Lawrence
name: Riechers, Dominik A.
name: Stacey, Gordon
name: Vaskuri, Anna K.
name: Vavagiakis, Eve M.
name: Wheeler, Jordan
name: Zou, Bugao
Publisher: name: arXiv
Year: 2024
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Epoch of Reionization Spectrometer (EoR-Spec) is an upcoming Line Intensity Mapping (LIM) instrument designed to study the evolution of the early universe (z = 3.5 to 8) by probing the redshifted [CII] 158 $μ$m fine-structure line from aggregates of galaxies. The [CII] emission is an excellent tracer of star formation since it is the dominant cooling line from neutral gas heated by OB star light and thus can be used to probe the reionization of the early Universe due to star formation. EoR-Spec will be deployed on Prime-Cam, a modular direct-detection receiver for the 6-meter Fred Young Submillimeter Telescope (FYST), currently under construction by CPI Vertex Antennentechnik GmbH and to be installed near the summit of Cerro Chajnantor in the Atacama Desert. This instrument features an image plane populated with more than 6500 Microwave Kinetic Inductance Detectors (MKIDs) that are illuminated by a 4-lens optical design with a cryogenic, scanning Fabry-Perot Interferometer (FPI) at the pupil of the optical system. The FPI is designed to provide a spectral resolving power of $R\sim100$ over the full spectral range of 210--420 GHz. EoR-Spec will tomographically survey the E-COSMOS and E-CDFS fields with a depth of about 4000 hours over a 5 year period. Here we give an update on EoR-Spec's final mechanical/optical design and the current status of fabrication, characterization and testing towards first light in 2026.
description: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy XII
Tachyon physics with trapped ions
Creators: name: Lee, Tony E.
name: Alvarez-Rodriguez, Unai
name: Cheng, Xiao-Hang
name: Lamata, Lucas
name: Solano, Enrique
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It has been predicted that particles with imaginary mass, called tachyons, would be able to travel faster than the speed of light. There has not been any experimental evidence for tachyons occurring naturally. Here, we propose how to experimentally simulate Dirac tachyons with trapped ions. Quantum measurement on a Dirac particle simulated by a trapped ion causes it to have an imaginary mass so that it may travel faster than the effective speed of light. We show that a Dirac tachyon must have spinor-motion correlation in order to be superluminal. We also show that it exhibits significantly more Klein tunneling than a normal Dirac particle. We provide numerical simulations of realistic ion systems and show that our scheme is feasible with current technology.
description: 6 pages, 5 figures
(500953) James Comely
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mantle-driven dynamic uplift of the Rocky Mountains and Colorado Plateau and its surface response: Toward a unified hypothesis
Creators: name: Donahue, M.S.
name: Hoffman, M.
name: Feldman, J.
name: Karlstrom, K.E.
name: Dueker, K.
name: Kelley, S.
name: MacCarthy, J.
name: VanWijk, J.
name: Aslan, A.
name: Garcia, R.V.
name: Crow, R.
name: Stockli, D.F.
name: Coblentz, D.
name: Ouimet, W.
name: Lazear, G.
name: McKeon, R.
name: Darling, A.
name: Hansen, S.M.
name: Heizler, M.
name: Schmandt, B.
name: Aster, R.
name: Crossey, L.J.
name: Stachnik, J.
name: Kirby, E.
Publisher: name: Geological Society of America
Year: 2012

description: The correspondence between seismic velocity anomalies in the crust and mantle and the differential incision of the continental-scale Colorado River system suggests that significant mantle-to-surface interactions can take place deep within continental interiors. The Colorado Rocky Mountain region exhibits low-seismic-velocity crust and mantle associated with atypically high (and rough) topography, steep normalized river segments, and areas of greatest differential river incision. Thermochronologic and geologic data show that regional exhumation accelerated starting ca. 6-10 Ma, especially in regions underlain by low-velocity mantle. Integration and synthesis of diverse geologic and geophysical data sets support the provocative hypothesis that Neogene mantle convection has driven long-wavelength surface deformation and tilting over the past 10 Ma. Attendant surface uplift on the order of 500-1000 m may account for ~25%-50% of the current elevation of the region, with the rest achieved during Laramide and mid-Tertiary uplift episodes. This hypothesis highlights the importance of continued multidisciplinary tests of the nature and magnitude of surface responses to mantle dynamics in intraplate settings.
Gas-liquid critical point of the ultrasoft restricted primitive model from analytic theory
Creators: name: Patsahan, O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Gas-liquid criticality in the ultrasoft restricted primitive model (URPM) of polyelectrolytes is studied using the collective variables-based theory. For the model, an effective Hamiltonian is derived and explicit expressions for all the coefficients are found in a one-loop approximation. Based on this Hamiltonian, the phase and critical behaviour is analysed. Our results provide evidence that the nature of the gas-liquid criticality in the URPM is the same as in the restricted primitive model that includes a hard core.
description: 6 pages, 2 figures
Timing and magnitude of shortening within the inner fore arc of the Japan Trench
Creators: name: Kirby, E.
name: Regalla, C.
name: Fisher, D.
Publisher: name: Blackwell Publishing Ltd
Year: 2010

description: New structural data and kinematic modeling provide evidence for Plio-Quaternary, inner fore-arc shortening inboard of the Japan Trench, northeastern Honshu, accommodated by the Futaba fault, a high-angle, basement-involved fault that bounds the Abukuma massif on the east. Significant throw along the Futaba fault associated with exhumation of the massif is implied by a regionally extensive footwall syncline, the absence of Neogene sediments in the hanging wall, and high relief in the hanging wall adjacent to the fault. Kinematic fault-related fold modeling best reproduces fold geometry with 2.0-3.1 km of dip slip along a 40°-55° west dipping reverse fault. At the southern tip of the fault, tephra horizons of known age within units that predate and postdate deformation bracket the onset of deformation to 3.95-5.6 Ma and are used to calculate an average slip rate of 0.5-0.7 mm/yr, a throw rate of 0.3-0.5 mm/yr, and a shortening rate of 0.3-0.5 mm/yr. The northeastern Japan subduction zone is viewed as a classic example of an erosive margin, where offshore subsidence records have been used to argue for Neogene basal erosion of the upper plate. Tectonic erosion rates have been estimated from reconstructions of the paleomargin that assume no upper plate deformation and temporally constant fore-arc taper. Evidence presented here for Neogene fore-arc shortening, however, suggests that the upper plate is deformable and implies that that offshore subsidence records may reflect a combination of tectonic erosion and upper plate shortening.
L’immagine della città costruita. Percezioni e linguaggi architettonici della città di Argenta
Creators: name: Bondanelli, Michele
Publisher: name: Sezione di Lettere
Year: 2020

description: What is the image of the city of Argenta? The evolutionary path of the small urban center of Ferrara today poses important questions both about its ancient form and its future structure. The years of planning produced a loss of architectural identity, where the absence of the ancient form proved to be penalizing contrary to what was hoped for in the post-war reconstruction.
description: Sezione di Lettere, Supplemento XIV (2019)
Giacomo Vighi da Argenta all’Europa passando per Ferrara: il punto sugli studi
Creators: name: Vicentini, Cecilia
Publisher: name: Sezione di Lettere
Year: 2020

description: Jacopo (Giacomo, Jacopo) Vighi was a painter born, around 1510, in Argenta, near Ferrara. We know only three paintings certainly ascribable to him and are all portrait, in fact he made portraits first at the Este Court in Ferrara, especially with Ercole II, then, starting from 1561 in Turin, at the Savoye Court. After the Duke Emanuele Filiberto called Vighi to his court, he was addressed toward the most important courts in Italy and in Europe (Franch, Spanish, Augsburg) where he refined his style perfectly according to the taste of in-ternational official portraiture. Thanks to new documents, it is now possible to delineate more precisely some phases of his biography and to clarify the system of models he chose to accomplish the diplomatic needs and the taste of the most important rulers of the XVI Century.
description: Sezione di Lettere, Supplemento XIV (2019)
Coherence and population dynamics of chlorophyll excitations in FCP complex: Two-dimensional spectroscopy study
Creators: name: Butkus, Vytautas
name: Gelzinis, Andrius
name: Augulis, Ramūnas
name: Gall, Andrew
name: Büchel, Claudia
name: Robert, Bruno
name: Zigmantas, Donatas
name: Valkunas, Leonas
name: Abramavicius, Darius
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The energy transfer processes and coherent phenomena in the fucoxanthin-chlorophyll protein complex, which is responsible for the light harvesting function in marine algae diatoms, were investigated at 77 K by using two-dimensional electronic spectroscopy. Experiments performed on the femtosecond and picosecond timescales led to separation of spectral dynamics, witnessing evolutions of coherence and population states of the system in the spectral region of ${\rm Q}_{y}$ transitions of chlorophylls $a$ and $c$. Analysis of the coherence dynamics allowed us to identify chlorophyll (Chl) $a$ and fucoxanthin intramolecular vibrations dominating over the first few picoseconds. Closer inspection of the spectral region of the ${\rm Q}_{y}$ transition of Chl $c$ revealed previously not identified mutually non-interacting chlorophyll $c$ states participating in femtosecond or picosecond energy transfer to the Chl $a$ molecules. Consideration of separated coherent and incoherent dynamics allowed us to hypothesize the vibrations-assisted coherent energy transfer between Chl $c$ and Chl $a$ and the overall spatial arrangement of chlorophyll molecules.
Alkaloids of Adhatoda vasica Nees. as potential inhibitors of cyclooxygenases – an in-silico study
Creators: name: Ghanta, Prasanth
name: Doble, Mukesh
name: Ramaiah, Basavaraju
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Eicosanoid pathways play a crucial role in the progression and resolution of inflammation. NSAIDs act as anti-inflammatory agents by inhibiting both the isoforms of cyclooxygenases (COXs) whereas, COXIBs act as specific COX-2 inhibitors. Excessive usage of the same is linked with gastrointestinal bleeding and increased cardiovascular risk, respectively. The current in-silico study was aimed at evaluating the potential of major alkaloids of A. vasica (vasicine (VAS), vasicinone (VAE), and Deoxyvasicine (DOV)) as inhibitors of COXs. The results of the computed binding energy (ΔG) indicate that Celecoxib (CEL), DOV, and VAS have a higher affinity to COX-2, while VAE has a higher affinity to COX-1, and Mefenamic acid (MEF) was not selective. Among the alkaloids, VAE exhibited the best ΔG (of −8.2 kcal/mol) with COX-1, while VAS exhibited the best ΔG (of −8.2 kcal/mol) with COX-2. This was comparable to the ΔG exhibited by Mefenamic acid (-8.7 kcal/mol with both the COXs). With their potential to remain gastroprotective while having the ability to inhibit enzymes of both the prostaglandin and leukotriene pathways, the alkaloids of A. vasica could be promising leads for the design of Eicosanoid pathway modulators/inhibitors. Communicated by Ramaswamy H. Sarma
Millennial slip rates along the eastern Kunlun fault: Implications for the dynamics of intracontinental deformation in Asia
Creators: name: Chun, F.
name: Burbank, D.
name: Wang, E.
name: Shi, X.
name: Kirby, E.
name: Harkins, N.
Publisher: name: Geological Society of America
Year: 2010

description: The role of major strike-slip faults in the Indo-Asian collision zone is central to our understanding of the ways in which continental crust and lithosphere deform in response to continental collision. We investigated how slip varies along the eastern segments of the Kunlun fault in northeastern Tibet. Millennial slip rates were determined based on landforms that are offset by the fault and that were dated using a combination of 14 C and cosmogenic radionuclide exposure dating techniques. We developed estimates for slip rates at four new locations along the fault in addition to four previously published sites. All of these sites are located along the eastern 300 km of the fault system, and our results reveal a systematic eastward decrease in slip rate along this portion of the fault since the late Pleistocene. This displacement gradient is consistent with the termination of the Kunlun fault near ~102°E. Coincident variations in fault slip rates and geometry reflect complex kinematics along the fault zone. Although other faults exist in the region, our observations suggest that none of these accomplishes transfer of slip from the primary Kunlun fault system. Instead, we interpret that either the eastern Kunlun fault is relatively young and propagating eastward, or that left-lateral slip is absorbed by interaction of the fault zone with regional rotation of the eastern fault tip. Both of these scenarios contrast with previous interpretations and indicate that the Kunlun fault does not accommodate the eastward extrusion of the central Tibetan Plateau lithosphere.
(500954) Ann [Comely] nee Gill?
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Simulated performance of energy-resolving detectors towards exoplanet imaging with the Habitable Worlds Observatory
Creators: name: Steiger, Sarah
name: Pueyo, Laurent
name: Por, Emiel H.
name: Chen, Pin
name: Soummer, Rémi
name: Pourcelot, Raphaël
name: Laginja, Iva
name: Bailey, Vanessa P.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: One of the primary science goals of the Habitable Worlds Observatory (HWO) as defined by the Astro2020 decadal survey is the imaging of the first Earth-like planet around a Sun-like star. A key technology gap towards reaching this goal are the development of ultra-low-noise photon counting detectors capable of measuring the incredibly low count rates coming from these planets which are at contrasts of $\sim 1 \times 10^{-10}$. Superconducting energy-resolving detectors (ERDs) are a promising technology for this purpose as, despite their technological challenges, needing to be cooled below their superconducting transition temperature ($< 1\mathrm{K}$), they have essentially zero read noise, dark current, or clock-induced charge, and can get the wavelength of each incident photon without the use of additional throughput-reducing filters or gratings that spread light over many pixels. The use of these detectors on HWO will not only impact the science of the mission by decreasing the required exposure times for exo-Earth detection and characterization, but also in a wavefront sensing and control context when used for starlight suppression to generate a dark zone. We show simulated results using both an EMCCD and an ERD to ``dig a dark zone'' demonstrating that ERDs can achieve the same final contrast as an EMCCD in about half of the total time. We also perform a simple case study using an exposure time calculator tool called the Error Budget Software (EBS) to determine the required integration times to detect water for HWO targets of interest using both EMCCDs and ERDs. This shows that once a dark zone is achieved, using an ERD can decrease these exposure times by factors of 1.5--2 depending on the specific host star properties.
description: 13 pages, 7 figures
(500955) Henry Howard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Active site dynamics and catalytic mechanism in arabinan hydrolysis catalyzed by GH43 endo-arabinanase from QM/MM molecular dynamics simulation and potential energy surface
Creators: name: Meelua, Wijitra
name: Wanjai, Tanchanok
name: Thinkumrob, Natechanok
name: Oláh, Julianna
name: Mujika, Jon I.
name: Ketudat-Cairns, James R.
name: Hannongbua, Supa
name: Jitonnom, Jitrayut
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: The endo-1,5-α-L-arabinanases, belonging to glycoside hydrolase family 43 (GH43), catalyse the hydrolysis of α-1,5-arabinofuranosidic bonds in arabinose-containing polysaccharides. These enzymes are proposed targets for industrial and medical applications. Here, molecular dynamics (MD), potential energy surface and free energy (potential of mean force) simulations are undertaken using hybrid quantum mechanical/molecular mechanical (QM/MM) potentials to understand the active site dynamics, catalytic mechanism and the electrostatic influence of active site residues of the GH43 endo-arabinanase from G. stearothermophilus. The calculated results give support to the single-displacement mechanism proposed for the inverting GH43 enzymes: first a proton is transferred from the general acid E201 to the substrate, followed by a nucleophilic attack by water, activated by the general base D27, on the anomer carbon. A conformational change (2E ↔E3 ↔ 4E) in the −1 sugar ring is observed involving a transition state featuring an oxocarbenium ion character. Residues D87, K106, H271 are highlighted as potential targets for future mutation experiments in order to increase the efficiency of the reaction. To our knowledge, this is the first QM/MM study providing molecular insights into the glycosidic bond hydrolysis of a furanoside substrate by an inverting GH in solution. Communicated by Ramaswamy H. Sarma
A geological and geophysical context for the Wenchuan earthquake of 12 May 2008, Sichuan, People's Republic of China
Creators: name: Lü, J.
name: Li, C.
name: Hager, B.H.
name: Chen, Z.
name: Royden, L.H.
name: van der Hilst, R.D.
name: Kirby, E.
name: Yao, H.
name: King, R.W.
name: Burchfiel, B.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: On 12 May 2008, a magnitude 7.9 earthquake ruptured the Longmen Shan margin of the eastern Tibetan plateau. This event occurred within the context of long-term uplift and eastward enlargement of the plateau. The area has numerous geological features not typical of active convergent mountain belts, including the presence of a steep mountain front (>4 km relief) but an absence of large-magnitude low-angle thrust faults; young high topography (post ca. 15 Ma) and thickened crust but low global positioning system (GPS) shortening rates (<3 mm/yr); and no coeval foreland subsidence. In our interpretation, crustal thickening beneath the eastern Tibetan plateau occurred without large-scale shortening of the upper crust but instead is caused by ductile thickening of the deep crust in a weak (low-viscosity) layer. Late Cenozoic shortening across the Longmen Shan could be as little as 10-20 km, with folding and faulting mainly accommodating differential surface uplift between the plateau and the Sichuan Basin. The earthquake of 12 May probably reflects long-term uplift with slow convergence and right-slip, of the eastern plateau relative to the Sichuan Basin. GPS-determined rates in the vicinity of the 12 May event suggest an average recurrence interval of ∼2,000-10,000 yr.
Practical and Legal Challenges of Cloud Investigations
Creators: name: James, Joshua I.
name: Jang, Yunsik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: K.4.1; K.4.2

description: An area presenting new opportunities for both legitimate business, as well as criminal organizations, is Cloud computing. This work gives a strong background in current digital forensic science, as well as a basic understanding of the goal of Law Enforcement when conducting digital forensic investigations. These concepts are then applied to digital forensic investigation of cloud environments in both theory and practice, and supplemented with current literature on the subject. Finally, legal challenges with digital forensic investigations in cloud environments are discussed.
description: 7 pages
(500946) Alfred Hamilton Cruickshank
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Problèmes sociolinguistiques de la normalisation du sarde
Creators: name: Lai, Rosangela
Publisher: name: Sezione di Lettere
Year: 2019
Subjects: Sardinian, standardization, heritage speakers, Limba Sarda Comuna, Limba Sarda Unificada

description: Da decenni il sardo è classificato come lingua in pericolo dall’UNESCO, in virtù dell’interruzione della trasmissione parentale a cui si è assistito fra gli anni Sessanta e Ottanta. In un quadro linguistico così compromesso, le misure di pianificazione linguistica portate avanti dalla Regione Autonoma della Sardegna si sono rivelate sotto alcuni aspetti inadeguate. Come noto fin da Fishman (1991), il buon successo delle misure di standardizzazione presuppone misure volte a ripristinare la trasmissione intergenerazionale, cosa che nel caso della Sardegna non è avvenuta. Nel contributo si espongono e commentano le due proposte di standardizzazione proposte negli scorsi due decenni dalla Regione, evidenziandone gli elementi di criticità e le reazioni del pubblico e delle istituzioni
description: Sezione di Lettere, XIII (2018)
From listening to playing: reimagining musical participation through technology and collaboration
Creators: name: Frame, Ciaran Michael
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 360504
subject: Interactive media
classificationCode: 360302
subject: Music composition and improvisation
classificationCode: 360305
subject: Music technology and recording

description: This thesis investigates how new music technologies can help move audiences from listeners to players in musical experiences. The research is conducted using practice-based methods and critical reflection, and explores how audiences can participate in music through four main projects. These include interactive experiences ranging from a houshold object to a theatrical production. The thesis proposes practical music composition strategies to help active audience involvement in music, potentially revolutionising how we experience and participate in music in the future.
Structure-based design of small molecule and peptide inhibitors for selective targeting of ROCK1: an integrative computational approach
Creators: name: Ansar, Samdani
name: Vetrivel, Umashankar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Rho-associated, coiled-coil-containing protein kinase (ROCK1) regulates cell contraction, morphology, and motility by phosphorylating its downstream targets. ROCK1 is a proven target for many pathological conditions like cancer, atherosclerosis, glaucoma, neuro-degeneration, etc. Though many kinase inhibitors are available, there is a dearth of studies on repurposing approved drugs and novel peptide inhibitors that could potentially target ROCK1. Hence, in this study, an extensive integration of open-source pipelines was employed to probe the potential inhibitors (ligand/peptide) for targeting ROCK1. To start with, a systematic enrichment analysis was performed to delineate the most optimal ROCK1 crystal structure that can be harnessed for drug design. A comparative analysis of conformational flexibility between monomeric and dimeric forms was also performed to prioritize the optimal assembly for structural studies. Subsequently, Virtual screening of FDA-approved drugs in Drugbank was performed using POAP pipeline. Further, the top hits were probed for binding affinity, crucial interaction fingerprints, and complex stability during MD simulation. In parallel, a combinatorial tetrapeptide library was also virtually screened against ROCK1 using the PepVis pipeline. Following which, all these shortlisted inhibitors (compounds/peptides) were subjected to Kinomerun analysis to infer other potential kinase targets. Finally, Polydatin and conivaptan were prioritized as the most potential repurposable inhibitors, and WWWF, WWVW as potential inhibitory peptides for targeting ROCK1. The prioritized inhibitors are highly promising for use in therapeutics, as these are resultants of the multilevel stringent filtration process. The computational strategies implemented in this study could potentially serve as a scaffold towards selective inhibitor design for other kinases. Communicated by Ramaswamy H. Sarma
Fossil group origins - VI. Global X-ray scaling relations of fossil galaxy clusters
Creators: name: Kundert, A.
name: Gastaldello, F.
name: D'Onghia, E.
name: Girardi, M.
name: Aguerri, J. A. L.
name: Barrena, R.
name: Corsini, E. M.
name: De Grandi, S.
name: Jiménez-Bailón, E.
name: Lozada-Muñoz, M.
name: Méndez-Abreu, J.
name: Sánchez-Janssen, R.
name: Wilcots, E.
name: Zarattini, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first pointed X-ray observations of 10 candidate fossil galaxy groups and clusters. With these Suzaku observations, we determine global temperatures and bolometric X-ray luminosities of the intracluster medium (ICM) out to $r_{500}$ for six systems in our sample. The remaining four systems show signs of significant contamination from non-ICM sources. For the six objects with successfully determined $r_{500}$ properties, we measure global temperatures in the range $2.8 \leq T_{\mathrm{X}} \leq 5.3 \ \mathrm{keV}$, bolometric X-ray luminosities of $0.8 \times 10^{44} \ \leq L_{\mathrm{X,bol}} \leq 7.7\times 10^{44} \ \mathrm{erg} \ \mathrm{s}^{-1}$, and estimate masses, as derived from $T_{\mathrm{X}}$, of $M_{500} > 10^{14} \ \mathrm{M}_{\odot}$. Fossil cluster scaling relations are constructed for a sample that combines our Suzaku observed fossils with fossils in the literature. Using measurements of global X-ray luminosity, temperature, optical luminosity, and velocity dispersion, scaling relations for the fossil sample are then compared with a control sample of non-fossil systems. We find the fits of our fossil cluster scaling relations are consistent with the relations for normal groups and clusters, indicating fossil clusters have global ICM X-ray properties similar to those of comparable mass non-fossil systems.
description: 17 pages, 7 figures, 8 tables. Accepted for publication in MNRAS
I πονηροί tra Aristofane e l’oratoria
Creators: name: Labanca, Massimiliano
Publisher: name: Sezione di Lettere
Year: 2019
Subjects: Aristophanes, orators, politics, demagogues, πονηρός

description: The first aim of this paper is to illustrate the various meanings of the word πονηρός (together with the antonym χρηστός) and especially its usage from the last quarter of V century b.C. to the first half of IV, both in theatrical literature and in political jargon; the semantic gap between the etymological sense of this term and its occurrences in post-Periclean age is due to the great social renewals in VI-V cent. and next to the decline of the democratic parabola in Athens. Consequently, the paper shows the tight connections between comic and political lexicon: according to Alessandro Grilli, all Aristophanes’ comedies concern politics and therefore refer to its vocabulary in order to inspire audience’s laugh and blame.
description: Sezione di Lettere, XIII (2018)
Fluvial terrace riser degradation and determination of slip rates on strike-slip faults: An example from the Kunlun fault, China
Creators: name: Kirby, E.
name: Harkins, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The use of displaced fluvial terrace risers to determine slip rates along strike-slip faults depends on knowing when risers become passive markers. Typically, chronologic constraints from terrace deposits only place bounds on this age; consequent slip rates may be highly uncertain. Along the Kunlun fault, in northeastern Tibet, we demonstrate that consideration of riser degradation can augment terrace chronology and improve the precision of slip-rate estimates. Multiple offset risers and 14C age determinations from terrace treads yield a narrow range of slip rates of 4.5 ± 0.5 m/kyr at one site, but permit a wide range of allowable rates (3-10 m/kyr) in an adjacent drainage. Using a locally calibrated sediment transport rate of 3.2-5.4 m2/ka, we show that riser morphology at this latter site is consistent with degradation since abandonment of the upper terrace tread Our anal sis indicates that slip rates at this site are ∼5 ± 2 m/kyr.
L’io e l’Altro. La relazione come fondamento in Jerzy Grotowski
Creators: name: Strutyńska, Joanna
Publisher: name: Sezione di Lettere
Year: 2019
Subjects: Grotowsky

description: The questions about the relationship, about the real fact that arises between people, pushed Grotowski towards the theater and accompanied him along his path. So many imprints of this investigation are preserved up to now in the numerous essays left by the Polish director. On the following pages, based fundamentally on these writings, I address the topic of the human relationship and how it developed in the various phases of Grotowski's work. What place does the relation have in the Grotowski’s vision of theater. What are the various ways of meeting others in this theater. Why the search for a living relationship between I and Thou is important for an individual.Why the relationship with the Other is substantial for the development of the individual.I focused on the period "beyond the theater" (starting from the early seventies until 1998) because at that time Grotowski's work was no longer oriented to the creation of a play, but to the investigation of the possibility of meeting with the active participation of everyone, without division between the actors and the audience. The essays I referred to above were the starting point and the basis on which I carried out my research. I worked primarily with the Polish edition from 2012, which is the first complete collection of Grotowski's texts.
description: Sezione di Lettere, XIII (2018)
Unraveling the potential role of bioactive molecules produced by Trichoderma spp. as inhibitors of tomatinase enzyme having an important role in wilting disease: an in-silico approach
Creators: name: Singh, Garima
name: Tiwari, Abhay
name: Choudhir, Gourav
name: P, Hariprasad
name: Kumar, Anuj
name: Sharma, Satyawati
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Tomatinase; a saponin detoxification enzyme produced by Fusarium oxysporumf.sp. lycopersici is reported as a causative agent for wilting disease in tomato crops. The disease is instigated by inhibiting the activity of α-tomatine. Trichoderma spp. widely used as biocontrol agent play an essential role in plant growth and pathogen control. In the current study, an in-silico approach using substrate docking, molecular dynamics and MM/PBSA analysis was used to evaluate the potential role of bioactive metabolites produced by Trichoderma spp. The study aims to establish the efficacy of catalytic tendency of the bioactive metabolites to combat the effect of tomatinase enzyme employing α-tomatine as the substrate. By means of the integrated molecular modeling approach; novel bioactive metabolites namely, Trichodermamide B, Trichosetin and Virone were found to be the potential inhibitors against tomatinase enzyme secreted by Fusarium oxysporum f.sp. lycopersici. Molecular dynamic (MD) simulations displayed that the screened ligands bound tomatinase during 150 ns of MD simulations. Furthermore, the (MM-PBSA) free energy calculations depicted that screened molecules possess stable and favorable energies for Trichodermamide B (-7.1 kcal/mol), Trichosetin (-7.4 kcal/mol) and Virone (-7.9 kcal/mol) thereby instigating robust binding with the enzyme’s binding site. The results attained in this study, reflects that these bioactive metabolites may serve as potential substrates to control and inhibit the tomatinase enzyme; playing an integral role in combating the wilt disease. Communicated by Ramaswamy H. Sarma
Conjugate-Root Offset-QAM for Orthogonal Multicarrier Transmission
Creators: name: Matthé, Maximilian
name: Fettweis, Gerhard
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Current implementations of OFDM/OQAM are restricted to band-limited symmetric filters. To circumvent this, non-symmetric conjugate root (CR) filters are proposed for OQAM modulation. The system is applied to Generalized Frequency Division Multiplexing (GFDM) and a method for achieving transmit diversity with OQAM modulation is presented. The proposal reduces implementation complexity compared to existing works and provides a more regular phase space. GFDM/CR-OQAM outperforms conventional GFDM in terms of symbol error rate in fading multipath channels and provides a more localized spectrum compared to conventional OQAM.
description: 4pages, revised version submitted to IEEE WCL
“It’s not a question of talent but… time of life”. Il mito della star decaduta in La primavera romana della signora Stone, dal romanzo di Tennessee Williams al film di José Quintero
Creators: name: Pavesi, Diletta
Publisher: name: Sezione di Lettere
Year: 2019
Subjects: Tennessee Williams, José Quintero, Vivien Leigh, Fading Stars, Hollywood on Hollywood Movies

description: The Roman Spring of Mrs. Stone (1950) is the first experience of Tennessee Williams in the field of novel writing. As much as his successful plays, this short novel soon attracted the attention of Hollywood producers. In 1961 José Quintero directed a cinematic adaptation starring Vivien Leigh and Warren Beatty. In spite of Quintero’s elegant direction and Leigh’s intense acting performance, The Roman Spring of Mrs. Stone was coldly welcomed both by the moviegoers and by film critics. This article aims to show that this forgotten though audacious adaptation offers interesting analogies between the way Williams outlines the figure of the declining star, embodied by Karen Stone, and the portrayal of similar characters in several Hollywood metafictional films from the same years. In The Roman Spring of Mrs. Stone, as much as in some eminent “Hollywood on Hollywood movies” released between the late Fifties and the early Sixties, the declining diva emerges as a figure of disruption that challenges the relationship between femininity and the show-business, sexuality and the coming of age.
description: Sezione di Lettere, XIII (2018)
Late Pleistocene slip rate along the Owens Valley fault, eastern California
Creators: name: Anandakrishnan, S.
name: Phillips, F.
name: Marrero, S.
name: Kirby, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The Owens Valley fault zone (OVF) is one of the primary structures accommodating dextral shear across the Eastern California shear zone (ECSZ). Previous estimates of the Holocene slip rate along this structure rely on paleoseismic data and yield rates 2-3 times lower than those implied by geodetic velocities. Using displaced lava flows along the flank of Crater Mountain, we present the first estimate of slip rate along the OVF during the late Pleistocene. Subsurface characterization of the flow margin using a ground-penetrating radar (GPR) allows for relatively precise determination of dextral displacement, and terrestrial cosmogenic 36Cl exposure ages of samples from the flow surface yield slip rates between ∼2.8 - 4.5 mm/yr over the past 55-80 kyr. Our results suggest either that paleoseismic slip-rate estimates underestimate the long-term slip rate or that rates of strain release have not been steady during the latter part of the Quaternary.