Additional file 1 of Prognostic value of amyloid/tau/neurodegeneration (ATN) classification based on diagnostic cerebrospinal fluid samples for Alzheimer’s disease
Creators: name: Delmotte, Koen
name: Schaeverbeke, Jolien
name: Poesen, Koen
name: Vandenberghe, Rik
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Supplementary Table 1. Difference in MMSE at different time points relative to the reference class (A-/T-/N-) and to the baseline MMSE using linear mixed-effects model with random slope and imputation of missing values. The following CSF thresholds were used: 798 pg/mL for Aβ42, 87 pg/mL for p181-tau, 465 pg/mL for t-tau. Supplementary Table 2. Difference in MMSE at different time points relative to the reference class (A-/T-/N-) and to the baseline MMSE using linear mixed-effects model with random slope. The following CSF thresholds were used: 798 pg/mL for Aβ42, 58.9 pg/mL for p181-tau, 354 pg/mL for t-tau. Supplementary Table 3. Difference in MMSE at different time points relative to the reference class (A-/T-/N-) and to the baseline MMSE using linear mixed-effects model with random slope and imputation of missing values. The following CSF thresholds were used: 798 pg/mL for Aβ42, 58.9 pg/mL for p181-tau, 354 pg/mL for t-tau. Supplementary Table 4. Interaction of individual CSF biomarkers on evolution of MMSE using linear mixed-effects model and imputation of missing values. Supplementary Table 5. Distribution of syndrome diagnoses at the moment of the lumbar puncture per ATN class, based on the following cut-off values: 798 pg/mL for Aβ42, 87 pg/mL for p181-tau, 465 pg/mL for t-tau. MCI = mild cognitive impairment. Supplementary Table 6. Difference in MMSE at different time points relative to the reference class (A-/T-/N-) and to the baseline MMSE using linear mixed-effects model with random slope for patients with a syndrome diagnosis of mild cognitive impairment. The following CSF thresholds were used: 798 pg/mL for Aβ42, 87 pg/mL for p181-tau, 465 pg/mL for t-tau. Supplementary Table 7. Difference in MMSE at different time points relative to the reference class (A-/T-/N-) and to the baseline MMSE using linear mixed-effects model with random slope for patients with a syndrome diagnosis of dementia. The following CSF thresholds were used: 798 pg/mL for Aβ42, 87 pg/mL for p181-tau, 465 pg/mL for t-tau. Supplementary Table 8. Distribution of final etiological diagnoses per ATN class based on the clinical-diagnostic investigation including cerebrospinal fluid biomarkers. AD = Alzheimer’s disease. Other neurodeg = non-AD neurodegenerative disorders, including FTD (frontotemporal dementia), LBD (Lewy Body disease) and CBS (corticobasal syndrome). Non-neurodeg = no neurodegenerative disorders. ‘No diagnosis’ is reserved for patients without a clear diagnosis after standard clinical work-up.