cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Consonance of RDA in serials bibliographic records catalogues
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2017

description: The aim of this study is to determine that how much the serials bibliographic records Catalogues of National Library and Archive of IR of Iran are compatible with the RDA. This study is an applied study which has been conducted using survey method and the descriptive-analytic approach (comparative). The research community consists of 14,600 serial records existing in the National Bibliography of Iran and the research sample consists of 375 records. Data collection tools are a checklist and the mapping table. The results showed that 14.7 percent of the existing data in the records under study are totally congruous with the RDA elements and 83.5 percent are not congruous with these elements. And also 1.8 percent of these data are relatively congruous with RDA elements. Block 1 with an average of 167 has the most congruousness and block 4 with an average of 5 has the lowest compliance. Results also show that serials records have a small compliance with RDA rules. Block 1 has the highest and block 4 has the lowest compliance with the RDA elements. The main reason for being non-compliance is the emptiness of fields.
Empirical Investigation of Factors influencing Function as a Service Performance in Different Cloud/Edge System Setups
Creators: name: Lipitakis, Anastasia-Dimitra
name: Kousiouris, George
name: Nikolaidou, Mara
name: Bardaki, Cleopatra
name: Anagnostopoulos, Dimosthenis
Publisher: name: arXiv
Year: 2023
Subjects: subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Experimental data can aid in gaining insights about a system operation, as well as determining critical aspects of a modelling or simulation process. In this paper, we analyze the data acquired from an extensive experimentation process in a serverless Function as a Service system (based on the open source Apache Openwhisk) that has been deployed across 3 available cloud/edge locations with different system setups. Thus, they can be used to model distribution of functions through multi-location aware scheduling mechanisms. The experiments include different traffic arrival rates, different setups for the FaaS system, as well as different configurations for the hardware and platform used. We analyse the acquired data for the three FaaS system setups and discuss their differences presenting interesting conclusions with relation to transient effects of the system, such as the effect on wait and execution time. We also demonstrate interesting trade-offs with relation to system setup and indicate a number of factors that can affect system performance and should be taken under consideration in modelling attempts of such systems.
description: 24 pages, 14 Figures, Journal paper
Learning of couplings for random asymmetric kinetic Ising models revisited: random correlation matrices and learning curves
Creators: name: Bachschmid-Romano, Ludovica
name: Opper, Manfred
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We study analytically the performance of a recently proposed algorithm for learning the couplings of a random asymmetric kinetic Ising model from finite length trajectories of the spin dynamics. Our analysis shows the importance of the nontrivial equal time correlations between spins induced by the dynamics for the speed of learning. These correlations become more important as the spin's stochasticity is decreased. We also analyse the deviation of the estimation error from asymptotic optimality.
description: 17 pages and 4 figures
Additional file 1 of Intersectoral collaboration in the management of non-communicable disease’s risk factors in Iran: stakeholders and social network analysis
Creators: name: Bakhtiari, Ahad
name: Takian, Amirhossein
name: Majdzadeh, Reza
name: Ostovar, Afshin
name: Afkar, Mehdi
name: Rostamigooran, Narges
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 1: Appendix A. We have provided the concepts of network analysis in Appendix A to assist the readers in understanding.
A Simple Method for Quantifying Functional Selectivity and Agonist Bias
Creators: name: Muniz-Medina, Vanessa
name: Novick, Steven
name: Kenakin, Terry
name: Christopoulos, Arthur
name: Watson, Christian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Activation of seven-transmembrane (7TM) receptors by agonists does not always lead to uniform activation of all signaling pathways mediated by a given receptor. Relative to other ligands, many agonists are “biased” toward producing subsets of receptor behaviors. A hallmark of such “functional selectivity” is cell type dependence; this poses a particular problem for the profiling of agonists in whole cell test systems removed from the therapeutic one(s). Such response-specific cell-based variability makes it difficult to guide medicinal chemistry efforts aimed at identifying and optimizing therapeutically meaningful agonist bias. For this reason, we present a scale, based on the Black and Leff operational model, that contains the key elements required to describe 7TM agonism, namely, affinity (KA–1) for the receptor and efficacy (τ) in activating a particular signaling pathway. Utilizing a “transduction coefficient” term, log(τ/KA), this scale can statistically evaluate selective agonist effects in a manner that can theoretically inform structure–activity studies and/or drug candidate selection matrices. The bias of four chemokines for CCR5-mediated inositol phosphate production versus internalization is quantified to illustrate the practical application of this method. The independence of this method with respect to receptor density and the calculation of statistical estimates of confidence of differences are specifically discussed.
Differential orthogonality: Laguerre and Hermite cases with applications
Creators: name: Borrego-Morell, J.
name: Pijeira-Cabrera, H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: Let $μ$ be a finite positive Borel measure supported on R, $\LL[f] =xf''+(α+1-x)f'$ with $α>-1$, or $\LL[f] =\frac{1}{2}f''-xf'$, and $m$ a natural number. We study algebraic, analytic and asymptotic properties of the sequence of monic polynomials $\{Q_n\}_{n>m}$ orthogonal with respect to the operator $\LL$. We also provide a fluid dynamics model for the zeros of these polynomials.
description: arXiv admin note: text overlap with arXiv:1303.2479
(101231) Thomas George Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Improvement of signal-to-noise ratio of aorta in CT angiography by high-resolution kernel with iterative reconstruction
Creators: name: Takada, Ken
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Aneurysms
subject: Physics
subject: CT-Angiography
subject: CT
subject: Vascular

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Recently, computed tomography (CT) manufactures have developed iterative reconstruction (IR) algorithms. Many past study for IR in cardiovascular CT were reported, and almost all of them were suggested the IR can achieve noise/radiation dose...
Identification of the Benzyloxyphenyl Pharmacophore: A Structural Unit That Promotes Sodium Channel Slow Inactivation
Creators: name: Cummins, Theodore R.
name: Wang, Yuying
name: Wilson, Sarah M.
name: Piekarz, Andrew D.
name: King, Amber M.
name: White, Fletcher A.
name: Due, Michael R.
name: Salomé, Christophe
name: Kohn, Harold
name: Khanna, Rajesh
name: Barbosa, Cindy
name: Dustrude, Erik T.
name: Yang, Xiao Fang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Four compounds that contained the N-benzyl 2-amino-3-methoxypropionamide unit were evaluated for their ability to modulate Na+ currents in catecholamine A differentiated CAD neuronal cells. The compounds differed by the absence or presence of either a terminal N-acetyl group or a (3-fluoro)benzyloxy moiety positioned at the 4′-benzylamide site. Analysis of whole-cell patch-clamp electrophysiology data showed that the incorporation of the (3-fluoro)benzyloxy unit, to give the (3-fluoro)benzyloxyphenyl pharmacophore, dramatically enhanced the magnitude of Na+ channel slow inactivation. In addition, N-acetylation markedly increased the stereoselectivity for Na+ channel slow inactivation. Furthermore, we observed that Na+ channel frequency (use)-dependent block was maintained upon inclusion of this pharmacophore. Confirmation of the importance of the (3-fluoro)benzyloxyphenyl pharmacophore was shown by examining compounds where the N-benzyl 2-amino-3-methoxypropionamide unit was replaced by a N-benzyl 2-amino-3-methylpropionamide moiety, as well as examining a series of compounds that did not contain an amino acid group but retained the pharmacophore unit. Collectively, the data indicated that the (3-fluoro)benzyloxyphenyl unit is a novel pharmacophore for the modulation of Na+ currents.
Additional file 2 of Intersectoral collaboration in the management of non-communicable disease’s risk factors in Iran: stakeholders and social network analysis
Creators: name: Bakhtiari, Ahad
name: Takian, Amirhossein
name: Majdzadeh, Reza
name: Ostovar, Afshin
name: Afkar, Mehdi
name: Rostamigooran, Narges
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 2: Appendix B. defines the concepts of “appropriateness” and “feasibility”; the field of knowledge of experts and their numbers are also stated.
Additional file 3 of Intersectoral collaboration in the management of non-communicable disease’s risk factors in Iran: stakeholders and social network analysis
Creators: name: Bakhtiari, Ahad
name: Takian, Amirhossein
name: Majdzadeh, Reza
name: Ostovar, Afshin
name: Afkar, Mehdi
name: Rostamigooran, Narges
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 3: Appendix C.1. Network and node-level metrics. Appendix C.2. Network metrics, including degree, closeness, betweenness, and eigenvector centralities, computed for the different risk factors.
Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry
Creators: name: Walsh, Paul L.
name: Salahpour, Ali
name: McElligott, Zoé A.
name: Caron, Marc G.
name: Kile, Brian M.
name: Wightman, R. Mark
name: Bucher, Elizabeth S.
name: Guillot, Thomas S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Electrochemical detection with carbon-fiber microelectrodes has become an established method to monitor directly the release of dopamine from neurons and its uptake by the dopamine transporter. With constant potential amperometry (CPA), the measured current provides a real time view of the rapid concentration changes, but the method lacks chemical identification of the monitored species and markedly increases the difficulty of signal calibration. Monitoring with fast-scan cyclic voltammetry (FSCV) allows species identification and concentration measurements but often exhibits a delayed response time due to the time-dependent adsorption/desorption of electroactive species at the electrode. We sought to improve the temporal resolution of FSCV to make it more comparable to CPA by increasing the waveform repetition rate from 10 to 60 Hz with uncoated carbon-fiber electrodes. The faster acquisition led to diminished time delays of the recordings that tracked more closely with CPA measurements. The measurements reveal that FSCV at 10 Hz underestimates the normal rate of dopamine uptake by about 18%. However, FSCV collection at 10 and 60 Hz provide identical results when a dopamine transporter (DAT) blocker such as cocaine is bath applied. To verify further the utility of this method, we used transgenic mice that overexpress DAT. After accounting for the slight adsorption delay time, FSCV at 60 Hz adequately monitored the increased uptake rate that arose from overexpression of DAT and, again, was similar to CPA results. Furthermore, the utility of collecting data at 60 Hz was verified in an anesthetized rat by using a higher scan rate (2400 V/s) to increase sensitivity and the overall signal.
Interactive Fiction in Cinematic Virtual Reality: Epistemology, Creation and Evaluation
Creators: name: REYES REDONDO, MARIA CECILIA
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: This dissertation presents the Interactive Fiction in Cinematic Virtual Reality (IFcVR), an interactive digital narrative (IDN) that brings together the cinematic virtual reality (cVR) and the creation of virtual environments through 360� video within an interactive fiction (IF) structure. This work is structured in three components: an epistemological approach to this kind of narrative and media hybrid; the creation process of IFcVR, from development to postproduction; and user evaluation of IFcVR. In order to set the foundations for the creation of interactive VR fiction films, I dissect the IFcVR by investigating the aesthetics, narratological and interactive notions that converge and diverge in it, proposing a medium-conscious narratology for this kind of artefact. This analysis led to the production of an IFcVR functional prototype: ?ZENA?, the first interactive VR film shot in Genoa. ZENA?s creation process is reported proposing some guidelines for interactive and immersive film-makers. In order to evaluate the effectiveness of the IFcVR as an entertaining narrative form and a vehicle for diverse types of messages, this study also proposes a methodology to measure User Experience (UX) on IFcVR. The full evaluation protocol gathers both qualitative and quantitative data through ad hoc instruments. The proposed protocol is illustrated through its pilot application on ZENA. Findings show interactors' positive acceptance of IFcVR as an entertaining experience.
Non-equilibrium control of quantum systems and their phases
Creators: name: PORTA, SERGIO
Publisher: name: Universit� degli studi di Genova
Year: 2019

description: In the last years, one of the major aim of the condensed matter area of interest, at the same rate of fundamental research, is to produce new and substantial breakthrough innovations to be applied in the information technology world. Indeed, semiconductor-based devices have constantly improved their performances thanks to the ability of continually shrink the components inside chips. In this process, however, physical components cannot be reduced in size infinitely. All matter consists of atoms and, at the atomic level, particles behave according to the laws of quantum mechanics. With this respect, the control of quantum systems is becoming fundamental to go beyond the present technology and the engineering of powerful phases of matter, very hard to obtain in standard conditions, is one of the main goals people are trying to achieve. The realization of quantum computation devices, in this sense, strongly depends on these new ideas success. In this respect, researchers have faced the difficulty, both from the theoretical and the experimental points of view, to control the state of a quantum system. Quantum control, i.e. the control of quantum phenomena, is becoming one of the major concerns in condensed matter physics, even if results obtained in the recent past are mainly confined to static systems in equilibrium, due to the difficulty to experimentally manipulate out-of-equilibrium quantum systems and the absence of an efficient general theoretical framework to describe non-equilibrium dynamics. In this thesis, I address these currently open questions by inspecting several different condensed matter models, using various methods to drive the system out of equilibrium and focusing on its dynamical features as well as the properties of its equilibration towards a thermal or, more interestingly, non thermal steady state. I discuss the possibility to manipulate various systems to give rise to peculiar dynamical behaviors and corresponding steady states with properties not attainable in thermal equilibrium, ranging from quantum phase transitions and their dynamical counterparts to superconductivity.
title: Multimodal MRI findings of Megalencephalic Leukoencephalopathy with subcortical cysts
Creators: name: BOUGHANMI, WAFA
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: MR-Spectroscopy
subject: MR-Diffusion/Perfusion
subject: MR
subject: Neuroradiology brain
subject: Diagnostic procedure
subject: Seizure disorders

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare autosomal recessive disease characterized by macrocephaly and slowly progressive clinical course and caused by mutations in the gene MLC. In patients with typical clinical...
title: Artificial Intelligence and Deep Reinforcement Learning Stock Market Predictions
Creators: name: Brim, Andrew W.
Publisher: name: Utah State University
Year: 2022

description: Billions of dollars are traded automatically in the stock market every day, including algorithms that use artificial intelligence (AI) techniques, but there are still questions regarding how AI trades successfully. The black box nature of these AI techniques, namely neural networks, gives pause to entrusting it with valuable trading funds. This dissertation applies AI techniques to stock market trading strategies, but it also provides exploratory research into how these techniques predict the stock market successfully.
This dissertation presents the work of three research papers. The first paper presented in this dissertation applies a artificial intelligence technique, reinforcement learning, to candlestick pattern trading. This paper also analyzes how the DDQN trades, through the use of a more recent technique, feature map visualizations. The second and third paper analyze AI techniques in a pairs trading strategy. The first paper results show that the DDQN is able to outperform the S&P 500 Index returns. Results also show that the CNN is able to switch its attention from all the candles in a candlestick image to the more recent candles in the image, based on an event such as the coronavirus stock market crash of 2020.The second paper results show fuzzy logic applied to pairs trading strategy for 22 stock pairs, increases annual returns on average from 15% to 17%. The third paper results show a DDQN was able to accurately predict the spread of the Adobe/Red Hat pair, for positive returns. This dissertation shows that AI techniques are successful in predicting the stock market, but more importantly it provides research tools and methods to better understand and implement these techniques in stock market trading.
title: Periosteum: sometimes unseen and forgotten
Creators: name: Alvarado, Ana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Trauma
subject: Infection
subject: Cancer
subject: Education
subject: Digital radiography
subject: Musculoskeletal bone

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - To ilustrate the normal appearance of the periosteum and the different types of periosteal reaction on plain films. - To propose a diagnostic algorithm with emphasis on the differential...
Controlled Iontophoresis Coupled with Fast-Scan Cyclic Voltammetry/Electrophysiology in Awake, Freely Moving Animals
Creators: name: Carelli, Regina M.
name: Belle, Anna M.
name: Herr, Natalie R.
name: Wightman, R. Mark
name: Owesson-White, Catarina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Simultaneous electrochemical and electrophysiological data were recorded to evaluate the effects of controlled local application of dopaminergic agonists and antagonists in awake rats. Measurements were made with a probe consisting of a carbon-fiber microelectrode fused to three iontophoretic barrels used to introduce the drugs of interest. The probe and the manipulator used to position it in the brain of behaving animals were optimized to improve their performance. The effect of the dopamine autoreceptor on electrically stimulated release was demonstrated. Dopamine inhibited the release of endogenous dopamine whereas raclopride, a D2 antagonist, enhanced it, with similar responses in anesthetized and awake animals. We also examined changes in the firing rate of nucleus accumbens (NAc) neurons in awake animals during and after brief (15 s) iontophoretic ejections of SCH 23390 (D1 receptor antagonist) or raclopride. Changes in response to these antagonists were seen both immediately and on a prolonged time scale. Application of raclopride increased the firing rate in 40% of medium spiny neurons (MSNs), of which half responded immediately. Decreases in firing rate were observed in 46% of MSNs after SCH 23390 application. Only 11% of MSNs responded to both antagonists and one MSN (3%) showed no response to either drug. The same prolonged response in firing rate was seen for electrically stimulated and locally applied dopamine in 75% of MSNs. These results are in agreement with previously reported distributions for dopamine receptor subtypes on MSNs and probe the effects of dopamine on these cell populations.
Progetto digitale per spartiti, testi e note sugli allestimenti artistici nei documenti dell'Istituto Mazziniano di Genova
Creators: name: CAPOBIANCO, CHIARA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: Starting from researching musical documents, most of them unpublished, at the ?Mazzinian Archive Institute? in Genoa, my doctoral research will focus on a new, modern and innovative way to digitize music scores. My research is ideally divided into three phases: ? Archive research ? Examination and evaluation of the possibilities of digitizing ? Making a sound archive (?playing the archive?) The first step is completed, with a preliminary digitization of the unpublished scores stored in the archive. About the second phase, I would study and collect information from the academic field, and I was able to establish a dialogue with the National Archival System (SAN) to formalize a digital schedule which is compatible with the ministerial standards and usable on dedicated platforms (music archives http://musica.san.beniculturali.it/). The third and last step will be the realization of the sound archive, through the collaboration with the informatics department (Universit� degli Studi di Genova). This type of digitization generates a new way of using the scores themselves, which can go out of the purely musical scope to be included in the field of study at large, for example: cultural studies, media studies and anthropological field. In this paper I intend to present some case studies regarding sheet music and their use in a multidisciplinary way by researchers. This will open a new way of thinking and using the archive, and can be an opportunity to export the study of musical materials in other and complex fields.
(101227) Samuel James Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Percorsi attraverso i confini: un'etnografia delle esperienze delle donne richiedenti protezione internazionale e asilo tra Bolzano e il Brennero
Creators: name: CAROSELLI, SERENA
Publisher: name: Universit� degli studi di Genova
Year: 2020

description: This research aims to describe and monitor migration of women seeking international protection and asylum to show the forms of mobility they involve across the border area and the effects of time lived in contact with the asylum and reception devices . The context in which the observation is located is that of the Brenner border and the Autonomous Province of Bolzano: these places are affected by "secondary movements" both from the countries of northern Europe and from the regions within Italy. The reading keys that support the analysis will be foreseen: the first is the one that reads in the peculiar configuration of the recognition system present in Bolzano a category device towards women particularly excluded and ambiguous. The second is that which considers the dimension of time - individual, relational and institutional - as a productive element of surveillance in the experience of research subjects.
title: Spine balance restauration with Spine-Jack
Creators: name: Pozo Piñon, Francisco
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: Interventional non-vascular
subject: Fluoroscopy
subject: Vertebroplasty
subject: Trauma
subject: Prostheses

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: We are going to describe the different techniques used to treat the vertebral compression fractures, explain the technical details of the Spine-Jack Kyphoplasty, demonstrate the morphological changes achieved with this intervention and expose the...
Discovery of Lacosamide Affinity Bait Agents That Exhibit Potent Voltage-Gated Sodium Channel Blocking Properties
Creators: name: Khanna, Rajesh
name: Lee, Hyosung
name: Kohn, Harold
name: Dustrude, Erik T.
name: Yang, Xiao Fang
name: Park, Ki Duk
name: Wang, Yuying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Lacosamide ((R)-1) is a recently marketed, first-in-class, antiepileptic drug. Patch-clamp electrophysiology studies are consistent with the notion that (R)-1 modulates voltage-gated Na+ channel function by increasing and stabilizing the slow inactivation state without affecting fast inactivation. The molecular pathway(s) that regulate slow inactivation are poorly understood. Affinity baits are chemical reactive units, which when appended to a ligand (drug) can lead to irreversible, covalent modification of the receptor thus permitting drug binding site identification including, possibly, the site of ligand function. We describe, herein, the synthesis of four (R)-1 affinity baits, (R)-N-(4″-isothiocyanatobiphenyl-4′-yl)methyl 2-acetamido-3-methoxypropionamide ((R)-8), (S)-N-(4″-isothiocyanatobiphenyl-4′-yl)methyl 2-acetamido-3-methoxypropionamide ((S)-8), (R)-N-(3″-isothiocyanatobiphenyl-4′-yl)methyl 2-acetamido-3-methoxypropionamide ((R)-9), and (R)-N-(3″-acrylamidobiphenyl-4′-yl)methyl 2-acetamido-3-methoxypropionamide ((R)-10). The affinity bait compounds were designed to interact with the receptor(s) responsible for (R)-1-mediated slow inactivation. We show that (R)-8 and (R)-9 are potent inhibitors of Na+ channel function and function by a pathway similar to that observed for (R)-1. We further demonstrate that (R)-8 function is stereospecific. The calculated IC50 values determined for Na+ channel slow inactivation for (R)-1, (R)-8, and (R)-9 were 85.1, 0.1, and 0.2 μM, respectively. Incubating (R)-9 with the neuronal-like CAD cells led to appreciable levels of Na+ channel slow inactivation after cellular wash, and the level of slow inactivation only modestly decreased with further incubation and washing. Collectively, these findings have identified a promising structural template to investigate the voltage-gated Na+ channel slow inactivation process.
Additional file 1 of Decision-making ethics in regards to life-sustaining interventions: when physicians refer to what other patients decide
Creators: name: Sterie, Anca-Cristina
name: Jox, Ralf J.
name: Rubli Truchard, Eve
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Appendix 1: Transcription key adapted from the Jefferson (2004) transcription system.
Vaccine Nationalism and Trust in Leaders
Creators: name: Colombatto, Clara
name: Everett, Jim AC
name: Maréchal, Michel André
name: Crockett, Molly
name: Senn, Julien
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Global access to resources like vaccines is key for containing the spread of infectious diseases. However, wealthy countries often pursue nationalistic policies, stockpiling doses rather than redistributing them globally. One possible motivation behind vaccine nationalism is a belief among policymakers that citizens will mistrust leaders who prioritize global needs over domestic protection. In seven experiments (total N=4215 adults), we demonstrate that such concerns are misplaced: nationally representative samples across multiple countries with large vaccine surpluses (Australia, Canada, U.K., and U.S.) trusted redistributive leaders more than nationalistic leaders — even the more nationalistic participants. This preference generalized across different diseases, and manifested in both self-reported and behavioral measures of trust. Professional civil servants however had the opposite intuition and predicted higher trust in nationalistic leaders, and a non-expert sample also failed to predict higher trust in redistributive leaders. We discuss how policymakers’ inaccurate intuitions might originate from overestimating others’ self-interest.
New Constraints on the Star Formation History of the Star Cluster NGC 1856
Creators: name: Correnti, Matteo
name: Goudfrooij, Paul
name: Puzia, Thomas H.
name: de Mink, Selma E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use the Wide Field Camera 3 onboard the Hubble Space Telescope to obtain deep, high-resolution photometry of the young (age ~ 300 Myr) star cluster NGC1856 in the Large Magellanic Cloud. We compare the observed colour-magnitude diagram (CMD), after having applied a correction for differential reddening, with Monte Carlo simulations of simple stellar populations (SSPs) of various ages. We find that the main sequence turn-off (MSTO) region is wider than that derived from the simulation of a single SSP. Using constraints based on the distribution of stars in the MSTO region and the red clump, we find that the CMD is best reproduced using a combination of two different SSPs with ages separated by 80 Myr (0.30 and 0.38 Gyr, respectively). However, we can not formally exclude that the width of the MSTO could be due to a range of stellar rotation velocities if the efficiency of rotational mixing is higher than typically assumed. Using a King-model fit to the surface number density profile in conjunction with dynamical evolution models, we determine the evolution of cluster mass and escape velocity from an age of 10 Myr to the present age, taking into account the possible effects of primordial mass segregation. We find that the cluster has an escape velocity Vesc ~ 17 km/s at an age of 10 Myr, and it remains high enough during a period of ~ 100 Myr to retain material ejected by slow winds of first-generation stars. Our results are consistent with the presence of an age spread in NGC1856, in contradiction to the results of Bastian & Silva-Villa (2013).
description: 17 pages, 14 figures. Re-submitted to MNRAS after addressing all the comments by the referee
title: Vascular compressions syndromes of the abdomen and pelvis on multi-detector computed tomography (MDCT); From the myth to the images.
Creators: name: Maldonado Schoijet, Ignacio
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education
subject: Diagnostic procedure
subject: CT-High Resolution
subject: CT-Angiography
subject: CT
subject: Vascular
subject: Pelvis
subject: Abdomen
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: This educational exhibit aims to review the key imaging features in MDCT of vascular compression syndromes of the abdomen and pelvis, proposing an optimal image acquisition...
(101229) Sarah Louisa Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Computed tomography venography examination - whole body
Creators: name: Koković, Tijana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Veins / Vena cava
subject: Vascular
subject: CT
subject: CT-Angiography
subject: Diagnostic procedure
subject: Embolism / Thrombosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To emphasize the importance and utility of computed tomography venography (CTV) in clinical practice and to instruct young radiologists about the essence of CTV through presentation of usual and unusual series of...
title: Fluoroscopy at its finest: Post-operative assessment after laryngo-pharyngeal and upper gastrointestinal tract surgery
Creators: name: Zhong, Jim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Swallowing disorders
subject: Obstruction / Occlusion
subject: Cancer
subject: Dynamic swallowing studies
subject: Diagnostic procedure
subject: Contrast agent-oral
subject: Fluoroscopy
subject: CT
subject: Stomach (incl. Oesophagus)
subject: Gastrointestinal tract
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Present the common surgical techniques used in laryngeal and upper gastrointestinal surgery Describe the normal fluoroscopic imaging findings and complications following laryngo-pharyngeal and upper gastrointestinal surgery Give tips on technique...
Additional file 2 of Decision-making ethics in regards to life-sustaining interventions: when physicians refer to what other patients decide
Creators: name: Sterie, Anca-Cristina
name: Jox, Ralf J.
name: Rubli Truchard, Eve
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Appendix 2: Transcript in original language and translation for Conversation 35: Physician #14 (PHY14); Patient #46 (PAT46).
Interoception and Learning: Import to Understanding and Treating Diseases and Psychopathologies
Creators: name: Bevins, Rick A.
name: Besheer, Joyce
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Chemotherapeutic agents nauseate cancer patients. Some individuals with schizophrenia hear voices. Chronic pain can be reduced by analgesics. Nausea, voices, and pain are examples of internal (interoceptive) stimuli closely linked with a disease and/or its treatment. There is evidence that the perception and, hence, role of these internal stimuli can be modified by one’s learning history. There is also increased awareness by researchers and practitioners of the potential import of learning involving internal states to some diseases and psychopathologies. Unfortunately, the science, theory, and practice appear to be trailing behind awareness. In this mini-review, we describe two examples: smoking and panic disorder. While doing so, we discuss the need to develop translationally relevant animal models that will allow investigators to better understand the behavioral and neural mechanisms underlying interoception and learning.
Rational Chebyshev of Second Kind Collocation Method for Solving a Class of Astrophysics Problems
Creators: name: Parand, Kourosh
name: Khaleqi, Sajjad
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The Lane-Emden equation has been used to model several phenomenas in theoretical physics, mathematical physics and astrophysics such as the theory of stellar structure. This study is an attempt to utilize the collocation method with the Rational Chebyshev of Second Kind function (RSC) to solve the Lane-Emden equation over the semi-infinit interval [0; +infinity). According to well-known results and comparing with previous methods, it can be said that this method is efficient and applicable.
description: arXiv admin note: text overlap with arXiv:1008.2063
title: Role of ultrasound in the diagnosis and characterization of cervical masses
Creators: name: Eyheremendy, Eduardo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: Ultrasound-Spectral Doppler
subject: Ultrasound-Power Doppler
subject: Ultrasound-Colour Doppler
subject: Head and neck
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the normal anatomy and ultrasound technique for the evaluation of the cervical region To evaluate the usefulness of ultrasound as a diagnostic method for evaluating the pathology of the neck To describe the sonographic appearance of...
Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor
Creators: name: Hu, Yang
name: Gill, Joseph B.
name: Gilmour, Brian P.
name: Zhang, X. Peter
name: Blough, Bruce E.
name: Jin, Chunyang
name: Decker, Ann M.
name: Huang, Xi Ping
name: Roth, Bryan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: GPR88 is an orphan G-protein-coupled receptor (GPCR) enriched in the striatum. Genetic deletion and gene expression studies have suggested that GPR88 plays an important role in the regulation of striatal functions and is implicated in psychiatric disorders. The signal transduction pathway and receptor functions of GPR88, however, are still largely unknown due to the lack of endogenous and synthetic ligands. In this paper, we report the synthesis of a GPR88 agonist 2-PCCA and its pure diastereomers, which were functionally characterized in both transiently and stably expressing GPR88 HEK293 cells. 2-PCCA inhibited isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 but not in the control cells, suggesting that the observed cAMP inhibition is mediated through GPR88 and that GPR88 is coupled to Gαi. 2-PCCA did not induce calcium mobilization in GPR88 cells, indicating no Gαq-mediated response. A structure–activity relationship (SAR) study of 2-PCCA was also conducted to explore the key structural features for GPR88 agonist activity.
Chimeric Agents Derived from the Functionalized Amino Acid, Lacosamide, and the α-Aminoamide, Safinamide: Evaluation of Their Inhibitory Actions on Voltage-Gated Sodium Channels, and Antiseizure and Antinociception Activities and Comparison with Lacosamide and Safinamide
Creators: name: Park, Ki Duk
name: Wang, Yuying
name: Yang, Xiao Fang
name: Kohn, Harold
name: Dustrude, Erik T.
name: Ripsch, Matthew S.
name: Khanna, Rajesh
name: White, Fletcher A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neurological agents that have been extensively investigated and have displayed potent anticonvulsant activities in seizure models. Both compounds have been reported to modulate voltage-gated sodium channel activity. We have prepared a series of chimeric compounds, (R)-7–(R)-10, by merging key structural units in these two clinical agents, and then compared their activities with (R)-2 and (S)-3. Compounds were assessed for their ability to alter sodium channel kinetics for inactivation, frequency (use)-dependence, and steady-state activation and fast inactivation. We report that chimeric compounds (R)-7–(R)-10 in catecholamine A-differentiated (CAD) cells and embryonic rat cortical neurons robustly enhanced sodium channel inactivation at concentrations far lower than those required for (R)-2 and (S)-3, and that (R)-9 and (R)-10, unlike (R)-2 and (S)-3, produce sodium channel frequency (use)-dependence at low micromolar concentrations. We further show that (R)-7–(R)-10 displayed excellent anticonvulsant activities and pain-attenuating properties in the animal formalin model. Of these compounds, only (R)-7 reversed mechanical hypersensitivity in the tibial-nerve injury model for neuropathic pain in rats.
(101230) Francis Edward Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Complicated Jejunoileal Diverticulosis: An Unexpected Diagnosis
Creators: name: Ortiz Andrade, Cesar Augusto
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Haemorrhage
subject: Diverticula
subject: Education
subject: Diagnostic procedure
subject: Complications
subject: CT-High Resolution
subject: CT
subject: Gastrointestinal tract
subject: Emergency
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: This work aims to provide a thorough and comprehensive literary review of jejunoileal diverticulosis (JID) and its most common complications, including diverticulitis, bowel perforation, hemorrhage and intestinal obstruction, with emphasis on the...
Additional file 3 of Decision-making ethics in regards to life-sustaining interventions: when physicians refer to what other patients decide
Creators: name: Sterie, Anca-Cristina
name: Jox, Ralf J.
name: Rubli Truchard, Eve
Publisher: name: figshare
Year: 2022
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3. Appendix 3: Transcript in original language and translation of Conversation 44 (Physician #15: PHY15; Patient #55: PAT55).
Orientation of x-lines in asymmetric magnetic reconnection - mass ratio dependency
Creators: name: Liu, Yi-Hsin
name: Hesse, Michael
name: Kuznetsova, Masha
Publisher: name: arXiv
Year: 2015
Subjects: subject: Space Physics (physics.space-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Using fully kinetic simulations, we study the x-line orientation of magnetic reconnection in an asymmetric configuration. A spatially localized perturbation is employed to induce a single x-line, that has sufficient freedom to choose its orientation in three-dimensional systems. The effect of ion to electron mass ratio is investigated, and the x-line appears to bisect the magnetic shear angle across the current sheet in the large mass ratio limit. The orientation can generally be deduced by scanning through corresponding 2D simulations to find the reconnection plane that maximizes the peak reconnection electric field. The deviation from the bisection angle in the lower mass ratio limit can be explained by the physics of tearing instability.
description: 10 pages, 8 figures
(101226) Matilda Elizabeth Horwood
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.