cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mast cells drive systemic inflammation and compromised bone repair after trauma
Creators: name: Ragipoglu, Deniz
name: Bülow, Jasmin
name: Hauff, Kristin
name: Voss, Martin
name: Haffner-Luntzer, Melanie
name: Dudeck, Anne
name: Ignatius, Anita
name: Fischer, Verena
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Posttraumatic inflammation
subject: DDC 610 / Medicine & health
subject: Mast cells
subject: Inflammation
subject: Wounds and injuries
subject: Fracture healing
subject: Interleukin-6
subject: Trauma
subject: Entzündung
subject: Frakturheilung
subject: Mastzelle

description: There is evidence that mast cells contribute to inflammation induced by hemorrhagic shock, severe tissue injury or sepsis. Mast cells are highly responsive to alarm signals generated after trauma, and release many inflammatory mediators including interleukin-6, a key mediator of posttraumatic inflammation. An overwhelming posttraumatic inflammation causes compromised bone healing; however, the underlying cellular and molecular mechanisms are poorly understood. Recently, we found that mast cells trigger local and systemic inflammation after isolated fracture leading to uneventful bone repair. Here, we investigated whether mast cells critically contribute to trauma-induced compromised bone healing. Male Mcpt5-Cre+ R-DTA mice, which lack connective tissue type mast cells, and their mast cell-competent Cre− littermates underwent a femur fracture with/without thoracic trauma. Posttraumatic systemic and local inflammation and bone repair were assessed 3 h and 21 d post injury. Both, the systemic and pulmonary inflammation was significantly increased in mast cell-competent mice upon combined trauma compared to isolated fracture. In mast cell-deficient mice, the increase of inflammatory mediators in the circulation induced by the severe trauma was abolished. In the bronchoalveolar lavage fluid, the trauma-induced increase of inflammatory cytokines was not reduced, but the neutrophil invasion into the lungs was significantly diminished in the absence of mast cells. Locally in the fracture hematoma, mast cell-competent mice displayed reduced inflammatory mediator concentrations after combined trauma compared to isolated fracture, which was abolished in mast cell-deficient mice. Notably, while combined trauma resulted in compromised bone repair in mast cell-competent mice, indicated by significantly reduced bone and increased cartilage fracture callus contents, this was abolished in Mcpt5-Cre+ R-DTA mice. Therefore, mast cells contribute to trauma-induced compromised bone repair and could be a potential target for new treatment options to improve fracture healing in multiply injured patients.
title: Attraktivität über die Lebensspanne mit Fokus auf Shape oder die Proportionen des Alterns
Creators: name: Anzenbacher, Clara
Year: 2009

description: Diese Arbeit untersucht die Entwicklung der Attraktivität von weiblichen, dreidimensional gewonnenen Gesichtsstimuli zwischen 18 und 57 Jahren und den Einfluss von Shapemorphing sowie der Frontalen-, 30-Grad-, 90-Grad und dynamischen Präsentation der Stimuli darauf. Dabei stellte sich heraus, dass Männer ältere und vor allem älter eingeschätzte Stimuli negativer bewerten als jüngere. Bei weiblichen Ratern konnte kein Zusammenhang festgestellt werden. Der Einfluss der Fruchtbarkeit auf Attraktivitätseinschätzungen konnte bis zu geschätzten 60 Jahren bestätigt werden, wonach ein Anstieg der Einschätzungen durch die Überlegung: „sehr attraktiv für ihr relativ hohes Alter“ erklärt werden könnte. Auswirkungen des Morphens von Gesichtsproportionen der Stimuli zeigen sich in dieser Arbeit abhängig von dem dadurch entstehenden „Morphalter“. Höhere Alterseinschätzungen werden durch ein höheres Morphalter des Shapes erreicht. Bei der Mittelung des Shapes steigen die Attraktivitätseinschätzungen, wenn das Morphalter nicht zu stark von dem Alter der Textur abweicht. All diese Ergebnisse konnten in der Profilansicht gefunden werden. Durch die verschiedenen Winkelvorgaben wurde gezeigt, dass frontal vorgegebene Stimuli am negativsten, dynamisch vorgegebene am positivsten bewertet wurden. Hingegen wurden Gesichtsstimuli im Profil am jüngsten und dynamisch präsentierte am ältesten eingeschätzt. Zuletzt wurde die Selbsteinschätzung der Rater betrachtet. Dabei wurde festgestellt, dass ein Blick in den Spiegel die Selbsteinschätzung verschlechtert. Soziale Vergleichsprozesse können nur indirekt vermutet werden. Dabei treten höhere Selbsteinschätzungen von weiblichen Ratern in Verbindung mit Attraktivitätseinschätzungen der Gesichtsstimuli anderer auf, bei denen kein Geschlechtsunterschied festzustellen ist.
Design research & reflective practice: the facility of design-oriented research to translate practitioner insights into new understandings of design
Creators: name: Grocott, Lisa
Publisher: name: RMIT University
Year: 2024

description: This PhD research explores the potential of design-oriented research for investigating design practice. This project is interested in drawing attention to the value of a designer’s perspective, and showing how this perspective can play a more significant role in shaping how academic discourse frames and understands design. This goal is explored through the critical undertaking of a design-oriented research case study. In reflecting upon the methods adopted the project evaluates, from a practitioner’s perspective, the limitations and the opportunities of designing as a research methodology. Exploring the methodological practice of a designer-researcher, this project is driven to adopt and adapt studio-based methods and reflection-based research interventions that will promote the synergetic relationship between speculation and reflection. In noticing and accounting for the designer’s reflective conversation with the research situation, the project proposes strategies for how the back talk of a reflective design practice might be productively amplified to establish resonance and facilitate the external consultation of practitioner-led research.
Insights into phase transformations and degradation mechanisms in aluminum anodes for lithium-ion batteries
Creators: name: Tahmasebi, Mohammad Hossein
name: Kramer, Dominik
name: Mönig, Reiner
name: Boles, Steven T.
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Batteries - Lithium
subject: Films
subject: Aluminum anode
subject: Ex situ SEM
subject: DDC 540 / Chemistry & allied sciences
subject: Lithium cells
subject: Energy storage
subject: Lithium ion batteries
subject: Lithiumbatterie
subject: Energiespeicherung
subject: Lithium-Ionen-Akkumulator

description: Attempts to use aluminum-based anodes in lithium-ion batteries often fail due to fast capacity fading. Generally, this has been attributed to pulverization of the electrode and the large volume changes associated with the phase transformation between the crystalline α and β phases of Li-Al alloys. In this study, these transformations were investigated in aluminum films that were lithiated either electrochemically or via direct reaction with lithium metal. Scanning electron microscopy was used to image the samples at different stages of (de)lithiation. By imaging the same locations before and after each step, it can be seen that alloying between Li and Al proceeds from distinct nucleation sites. In situ and ex situ observations reveal that the α-to-β phase transformation is highly anisotropic and causes strong distortions of the film morphology, but only a relatively small amount of mechanical damage such as cracks and delamination. Comparisons between films that were lithiated to 70% and 100% of the theoretical capacity of LiAl indicate that the critical, irreversible damage is more dependent on depth of discharge than on the volume contraction caused by delithiation. Our observations challenge the pessimistic view that pulverization is unavoidable during the phase transformations of the Li-Al system.
sj-docx-1-cpc-10.1177_10556656231180086 - Supplemental material for Ethnic Differences in the Brazilian Population Influence the Impact of BMP4 Genetic Variants on Susceptibility of Nonsyndromic Orofacial Clefts
Creators: name: Rocha de Oliveira, Lilianny Querino
name: de Souza Nicolau, Hellen Carolliny
name: Barbosa Martelli, Daniella Reis
name: Martelli-Júnior, Hercílio
name: Scariot, Rafaela
name: Ayroza Rangel, Ana Lúcia Carrinho
name: de Almeida Reis, Silvia Regina
name: Coletta, Ricardo D.
name: Machado, Renato Assis
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-cpc-10.1177_10556656231180086 for Ethnic Differences in the Brazilian Population Influence the Impact of BMP4 Genetic Variants on Susceptibility of Nonsyndromic Orofacial Clefts by Lilianny Querino Rocha de Oliveira and Hellen Carolliny de Souza Nicolau, Daniella Reis Barbosa Martelli, Hercílio Martelli-Júnior, Rafaela Scariot, Ana Lúcia Carrinho Ayroza Rangel, Silvia Regina de Almeida Reis, Ricardo D. Coletta, Renato Assis Machado in The Cleft Palate Craniofacial Journal
CactoSim simulation framework initial prototype: project deliverable D6.1
Creators: name: Svorobej, Sergej
name: Byrne, James
name: Byrne, Peter J.
name: Groenda, Henning
name: Stier, Christian
name: Domaschka, Jörg
name: Wesner, Stefan
name: Krzywda, Jakub
name: Östberg, Per-Olov
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: Simulation
subject: Optimisation
subject: Framework
subject: Prototype
subject: Cloud
subject: Context-aware cloud topology
subject: Cloud services
subject: Data management
subject: DDC 004 / Data processing & computer science
subject: Cloud computing
subject: Electric network topology
subject: Datenmanagement
subject: Cloud Computing

description: This deliverable provides supporting documentation for the official deliverable D6.1, the initial release of the CactoSim simulation framework. It presents the reader with the scope of the deliverable, initial requirements and architectural design for CactoSim. Updated requirements are given, and the foundations that CactoSim are built upon are described. A description of the architecture of the CactoSim V1.0 release is given, and this leads into a description of the graphical user interface by which users can interact with the tool. Provisioning is described, as well as licensing information. Finally, a feature description is given for CactoSim, with an overview of planned future releases also described.
sj-docx-2-cpc-10.1177_10556656231180086 - Supplemental material for Ethnic Differences in the Brazilian Population Influence the Impact of BMP4 Genetic Variants on Susceptibility of Nonsyndromic Orofacial Clefts
Creators: name: Rocha de Oliveira, Lilianny Querino
name: de Souza Nicolau, Hellen Carolliny
name: Barbosa Martelli, Daniella Reis
name: Martelli-Júnior, Hercílio
name: Scariot, Rafaela
name: Ayroza Rangel, Ana Lúcia Carrinho
name: de Almeida Reis, Silvia Regina
name: Coletta, Ricardo D.
name: Machado, Renato Assis
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-2-cpc-10.1177_10556656231180086 for Ethnic Differences in the Brazilian Population Influence the Impact of BMP4 Genetic Variants on Susceptibility of Nonsyndromic Orofacial Clefts by Lilianny Querino Rocha de Oliveira and Hellen Carolliny de Souza Nicolau, Daniella Reis Barbosa Martelli, Hercílio Martelli-Júnior, Rafaela Scariot, Ana Lúcia Carrinho Ayroza Rangel, Silvia Regina de Almeida Reis, Ricardo D. Coletta, Renato Assis Machado in The Cleft Palate Craniofacial Journal
Barriers And Facilitators For Fitness Center Participation Among Adult People With Or Without Physical Disabilities: A Systematic Scoping Review Protocol
Creators: name: Nikolajsen, Helene
name: Sandal, Louise Fleng
name: Juhl, Carsten
name: Troelsen, Jens
name: Juul-Kristensen, Birgit
Publisher: name: Zenodo
Year: 2018
Subjects: Barriers, Facilitators, Fitness center, Participation, Scoping review

description: This scoping review protocol is based on the “JBI Scoping Review SR Protocol template”. The protocol is an a priori protocol of a coming scoping review article. This protocol is now available with open access to ensure transparency of the method, as the guideline for scoping review prescribe.
MODELING GAS-BRINE-MINERAL REACTIONS DURING UNDERGROUND HYDROGEN STORAGE
Creators: name: Huang, Zitong
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: Underground hydrogen storage
Sensitivity analysis
Reactive transport simulation
Subsurface geochemistry
Gas-brine-mineral reaction networks

description: Hydrogen (H₂) is a potentially carbon-neutral and versatile energy carrier. Underground hydrogen storage (UHS) offers a solution for large-scale energy storage, tackling the issues of location dependence, fluctuation, and forecasting inherent in renewable energy sources. To increase renewable energy storage capacity from GWh to TWh, sites with large capacity and easy accessibility, such as depleted natural gas reservoirs, need to be investigated. Due to its highly reactive nature, hydrogen can drive redox reactions involving electron transfer between itself (as the reductant) and both subsurface minerals and aqueous species (as the oxidants). These reactions can result in gaseous hydrogen loss and alter the storage capacity and injectivity of the reservoir through mineral dissolution and precipitation, requiring models that consider three-phase (i.e., gas-brine-mineral) reaction networks. To model reactive transport phenomena linked to H₂(g) loss under diverse geological conditions, we first conducted time-dependent batch simulations of H₂(g) loss in the subsurface using PHREEQC. The static and kinetic equilibrium reaction results were then integrated into a multiphase reactive transport model, PFLOTRAN, providing a complete simulation of H₂(g) loss under realistic injection and storage conditions. The resulting suite of model simulations reflects an abiotic reaction network among H₂(g) and common subsurface minerals in the H₂-H₂O-CO₂-SiO₂-Ca-Al-Fe-S system. The formation of toxic gases from the reactions, such as hydrogen sulfide (H₂S(g)), was also examined. The results indicate that the reduction of Fe(III)-bearing minerals, such as hematite (Fe₂O₃) and goethite (FeOOH), is the primary control on subsurface H₂(g) loss. Quartz-rich sandstone reservoirs could be favorable for hydrogen storage due to their small reactivity with H₂(g). In addition, hydrogen dissolution in brine has a small impact on overall storage efficiency. Finally, we performed local and global sensitivity analyses to identify the key parameters influencing subsurface H₂(g) loss and H₂S(g) formation during storage. This study integrates reactive transport modeling with sensitivity analyses to enhance the safe and efficient implementation of large-scale underground hydrogen storage and provide critical insights into calculating the overall round-trip efficiency of hydrogen from generation to utilization. The findings from these sensitivity analyses highlight critical areas for future experimental studies.
Nachhaltige Entwicklung: der lange Weg von Stockholm (1972) nach Kopenhagen (2009)
Creators: name: Hamm, Bernd
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 320 / Political science
subject: Sustainable development
subject: Online-Publikation
subject: Ringvorlesung
subject: Umweltpolitik

description: Der Vortrag analysiert fast 40 Jahre internationale Zusammenarbeit im Bereich Umwelt und Nachhaltigkeit: von der "UNO-Weltkonferenz über die menschliche Umwelt" in Stockholm 1972 bis zur UN-Klimakonferenz, die im Dezember 2009 in Kopenhagen stattfinden wird.
title: Challenges and Recommendations for Managing Genomic High-Throughput Data in the Clinic
Creators: name: Umbach, Nadine
name: Beißbarth, Tim
name: Duttge, Gunnar
name: Flatau, Laura
name: Kuhn-Aldea, Jessica
name: Perera-Bel, Julia
name: Roschauer, Julia
name: Schulze, Thomas G.
name: Schweda, Mark
name: Trostmann, Julian
name: Urban, Alexander
name: Zimmermann, Anja
name: Sax, Ulrich
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Medizinische Informatik
subject: 610 Medical sciences; Medicine

description: Introduction: Genomic high-throughput technologies (gHTT) such as next-generation sequencing promise the comprehensive understanding of complex diseases. However, with its increasing application, it is necessary to understand the challenges, limitations, and benefits patients, physicians and other professionals[for full text, please go to the a.m. URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
Additional file 1 of Soluble Periostin is a potential surveillance biomarker for early and long-term response to chemotherapy in advanced breast cancer
Creators: name: Jia, Li
name: Hu, Wenwei
name: Yan, Xu
name: Shao, Jie
name: Guo, Yuhong
name: Zhang, Aimin
name: Yu, Lianzi
name: Zhou, Yunli
name: Li, Yueguo
name: Ren, Li
name: Dong, Dong
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 1: Molecular subtype, chemotherapy regimens, and response in chemotherapy efficacy monitoring.
Development of a wire reference electrode for lithium all-solid-state batteries with polymer electrolyte: FEM simulation and experiment
Creators: name: Simon, Fabian J.
name: Blume, Leonard
name: Hanauer, Matthias
name: Sauter, Ulrich
name: Janek, Jürgen
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: electrochemical impedance spectroscopy
subject: polymer electrolyte
subject: reference electrode
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 620 / Engineering & allied operations
subject: Polyelectrolytes
subject: Elektrode

description: Electrochemical impedance spectroscopy (EIS) is a powerful technique to study interface kinetics in lithium ion batteries. In order to separate the contributions of the working and counter electrode, a reference electrode (RE) is crucial. However, size and shape of the RE strongly influence the quality of the measurement data. In this study we define two criteria that enable the theoretical quality assessment of a wire-shaped RE as a function of its diameter. With help of a simplified Newman-type battery model we show that small wire diameters are essential in order to obtain meaningful EIS data, in particular when using polymer electrolytes, which have comparably low ionic conductivity. Therefore, a gold plated tungsten wire with 10 μm diameter is chosen as preferred RE. It is placed between two layers of electrolyte and lithiated before use to ensure a long-term stable reference potential. Using this setup, artifact-free EIS spectra are obtained for lithium/lithium and lithium/LFP cells with polymer electrolyte. Finally, two applications are shown for which a RE is indispensable: (I) the symmetry of anodic and cathodic lithium dissolution and deposition kinetics is characterized; (II) the growth of the anode and cathode impedance of a lithium/LFP cell during cycling is monitored.
title: Tutorium zum Datenschutz in der medizinischen Forschung
Creators: name: Drepper, Johannes
name: Pommerening, Klaus
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Medizinische Dokumentation
subject: Medizinische Informatik
subject: 610 Medical sciences; Medicine

description: Inhalt des Tutorials: Zunächst werden verschiedene Typen von Forschungsprojekten mit ihren unterschiedlichen Anwendungsfällen vorgestellt. Fokussiert werden Projekte aus dem Umfeld der klinischen Forschung, in denen das Recht auf informationelle Selbstbestimmung der Teilnehmer (Patienten oder[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
Emotional components of pain perception in borderline personality disorder and major depression : a repetitive Peripheral Magnetic Stimulation (rPMS) study
Creators: name: Malejko, Kathrin
name: Huss, André Michael
name: Schönfeldt-Lecuona, Carlos
name: Braun, Maren Sophie
name: Graf, Heiko
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: repetitive peripheral magnetic stimulation
subject: rPMS
subject: DDC 610 / Medicine & health
subject: Borderline personality disorder
subject: Depression
subject: Pain
subject: Borderline-Persönlichkeitsstörung
subject: Depression
subject: Magnetische Stimulation
subject: Schmerz

description: Various studies suggested alterations in pain perception in psychiatric disorders, such as borderline personality disorder (BPD) and major depression (MD). We previously investigated affective components of pain perception in BPD compared to healthy controls (HC) by increasing aversive stimulus intensities using repetitive peripheral magnetic stimulation (rPMS) and observed alterations in emotional rather than somatosensory components in BPD. However, conclusions on disorder specific alterations in these components of pain perception are often limited due to comorbid depression and medication in BPD. Here, we compared 10 patients with BPD and comorbid MD, 12 patients with MD without BPD, and 12 HC. We applied unpleasant somatosensory stimuli with increasing intensities by rPMS and assessed pain threshold (PT), cutaneous sensation, emotional valence, and arousal by a Self-Assessments Manikins scale. PTs in BPD were significantly higher compared to HC. The somatosensory discrimination of stimulus intensities did not differ between groups. Though elevated rPMS intensities led to increased subjective aversion and arousal in MD and HC, these emotional responses among intensity levels remained unchanged in BPD. Our data give further evidence for disorder-specific alterations in emotional components of pain perception in BPD with an absent emotional modulation among varying aversive intensity levels
title: Hemerobie der Wälder im Biosphärenpark Wienerwald
Creators: name: Enzenhofer, Karin
Year: 2009

description: Das Konzept der Hemerobie gilt als Maß zur Beschreibung des Kultureinflusses. Die MAB-Studie „Hemerobie österreichischer Waldökosysteme“ lieferte 1998 erstmals fundierte Kenntnisse über den Zustand der Wälder. Im Rahmen der vorliegenden Arbeit wurde dieses Konzept erneut aufgegriffen und eine Hemerobiestudie im niederösterreichischen Teil des Biosphärenparks Wienerwald auf Flächen der Österreichischen Bundesforste durchgeführt. Um die Vergleichbarkeit zu gewährleisten basiert die gesamte Methodik von der Felderhebung bis zur Hemerobiebewertung auf der MAB-Hemerobiestudie. Somit umfasst die Felderhebung die Aufnahme von Vegetationsdaten, bestandesstrukturelle Kriterien, Hemerobiekriterien und Standortsdaten. Bei der nachfolgenden Auswertung wird ein standardisiertes Bewertungsverfahren, welches die einzelnen Hemerobiekriterien gewichtet und durch verschiedene Verknüpfungsmethoden zu einem Gesamthemerobiewert aggregiert, angewendet. Ergebnisse dieser Arbeit sind eine vegetationsökologische Auswertung, eine Hemerobiebewertung und ein Vergleich zur MAB-Hemerobiesudie 1998 im Untersuchungsgebiet. Weiters soll eine ausführliche Diskussion einen Beitrag für künftige Monitoringstudien liefern.
title: Informed Consent – Update 2017
Creators: name: Michalik, Claudia
name: Alvarez Castillo, Carola
name: Oehlers, Hans
name: Schlünder, Irene
name: Röhrig, Rainer
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Biometrie
subject: Bioinformatik
subject: Epidemiologie
subject: Medizinische Dokumentation
subject: Medizinische Informatik
subject: 610 Medical sciences; Medicine

description: Eine der wichtigsten ethischen Voraussetzungen bei der Durchführung von Forschungsvorhaben ist die Freiwillige Entscheidung der Probanden und Patienten. Die freie Entscheidung setzt eine vorangegangen Aufklärung voraus. Neben der Deklaration von Helsinki [ref:1] gibt es weitere zahlreiche[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
title: Recent advances in the analysis of adverse events at varying follow-up times in the benefit assessment of therapies: recommendations by the ATF / APF project group
Creators: name: Unkel, Steffen
name: Ose, Claudia
name: Knoerzer, Dietrich
name: Skipka, Guido
name: Langer, Frank
name: Schmoor, Claudia
name: Proctor, Tanja
name: Beyersmann, Jan
name: Gillhaus, Johanna
name: Friede, Tim
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Biometrie
subject: 610 Medical sciences; Medicine

description: The analysis of adverse events is a key component in the assessment of a drug’s safety profile which is also required within the context of the early benefit assessment in Germany. Inappropriate analysis methods may result in misleading conclusions on a therapy’s safety and consequently[for full text, please go to the a.m. URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
title: Netzwerk Meta-Analyse für zielgerichtete Therapieoptionen
Creators: name: Jensen, Katrin
name: Proctor, Tanja
name: Kieser, Meinhard
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Biometrie
subject: 610 Medical sciences; Medicine

description: Einleitung: Die Entwicklung von zielgerichteten Therapien, die die individuelle Konstitution des Patienten einbeziehen, bildet einen Schwerpunkt der klinischen Forschung. Ein Beispiel ist die Wahl der optimalen Therapiestrategie in Abhängigkeit vom Nachweis spezieller Biomarker beim Patienten. [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
A nation-wide, multi-center study on the quality of life of ALS patients in Germany
Creators: name: Peseschkian, Tara
name: Cordts, Isabell
name: Günther, René
name: Stolte, Benjamin
name: Zeller, Daniel
name: Schröter, Carsten
name: Weyen, Ute
name: Regensburger, Martin
name: Wolf, Joachim
name: Schneider, Ilka
name: Hermann, Andreas
name: Metelmann, Moritz
name: Kohl, Zacharias
name: Linker, Ralf A.
name: Koch, Jan Christoph
name: Büchner, Boriana
name: Weiland, Ulrike
name: Schönfelder, Erik
name: Heinrich, Felix
name: Osmanovic, Alma
name: Klopstock, Thomas
name: Dorst, Johannes
name: Ludolph, Albert C.
name: Boentert, Matthias
name: Hagenacker, Tim
name: Deschauer, Marcus
name: Lingor, Paul
name: Petri, Susanne
name: Schreiber-Katz, Olivia
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5)
subject: ALS treatment
subject: EuroQol Five Dimension Five Level Scale (EQ-5D-5L)
subject: health-related quality of life (HRQoL)
subject: symptom-specific treatment
subject: assistive devices
subject: “limb-onset” ALS (lALS)
subject: “bulbar-onset” ALS (bALS)
subject: QoL
subject: ALS
subject: DDC 610 / Medicine & health
subject: Amyotrophic lateral sclerosis; Therapy
subject: Quality of life
subject: Surveys and questionnaires
subject: Myatrophische Lateralsklerose
subject: Therapie
subject: Lebensqualität

description: Improving quality of life (QoL) is central to amyotrophic lateral sclerosis (ALS) treatment. This Germany-wide, multicenter cross-sectional study analyses the impact of different symptom-specific treatments and ALS variants on QoL. Health-related QoL (HRQoL) in 325 ALS patients was assessed using the Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) and EuroQol Five Dimension Five Level Scale (EQ-5D-5L), together with disease severity (captured by the revised ALS Functional Rating Scale (ALSFRS-R)) and the current care and therapies used by our cohort. At inclusion, the mean ALSAQ-5 total score was 56.93 (max. 100, best = 0) with a better QoL associated with a less severe disease status (β = −1.96 per increase of one point in the ALSFRS-R score, p < 0.001). “Limb-onset” ALS (lALS) was associated with a better QoL than “bulbar-onset” ALS (bALS) (mean ALSAQ-5 total score 55.46 versus 60.99, p = 0.040). Moreover, with the ALSFRS-R as a covariate, using a mobility aid (β = −7.60, p = 0.001), being tracheostomized (β = −14.80, p = 0.004) and using non-invasive ventilation (β = −5.71, p = 0.030) were associated with an improved QoL, compared to those at the same disease stage who did not use these aids. In contrast, antidepressant intake (β = 5.95, p = 0.007), and increasing age (β = 0.18, p = 0.023) were predictors of worse QoL. Our results showed that the ALSAQ-5 was better-suited for ALS patients than the EQ-5D-5L. Further, the early and symptom-specific clinical management and supply of assistive devices can significantly improve the individual HRQoL of ALS patients. Appropriate QoL questionnaires are needed to monitor the impact of treatment to provide the best possible and individualized care.
Additional file 2 of Soluble Periostin is a potential surveillance biomarker for early and long-term response to chemotherapy in advanced breast cancer
Creators: name: Jia, Li
name: Hu, Wenwei
name: Yan, Xu
name: Shao, Jie
name: Guo, Yuhong
name: Zhang, Aimin
name: Yu, Lianzi
name: Zhou, Yunli
name: Li, Yueguo
name: Ren, Li
name: Dong, Dong
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 2: Comparison of preoperative and postoperative levels of three markers in serum of BCa patients. Representation of individual markers, A: POSTN, B: CA15-3, C: CEA. n = 15.
title: Durchführen geplanter und ungeplanter Zwischenanalysen in Klinischen Studien
Creators: name: Eveslage, Maria
name: Ligges, Sandra
name: Ehrhardt, Stephan
name: Müller, Hermann
name: Faldum, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Biometrie
subject: 610 Medical sciences; Medicine

description: Einleitung: Gruppensequentielle Designs ermöglichen die Durchführung konfirmatorischer  Zwischenanalysen in klinischen Studien. Durch die Möglichkeit, die Studie bei unerwartet großen Effekten vorzeitig zu beenden bzw. sie bei zu geringen Erfolgsaussichten abzubrechen, ermöglichen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
Anwendungsspezifische Anforderungen an Workflow-Mangement-Systeme am Beispiel der Domäne Concurrent-Engineering
Creators: name: Beuter, Thomas
name: Dadam, Peter
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Computer-supported cooperative work
subject: Workflow management systems
subject: Prozessmanagement
subject: Simultaneous Engineering

description: N/A
title: Fallzahlkorrektur bei Powerverlust durch Imbalancen der Blockrandomisation am Beispiel des t-Tests
Creators: name: Muche, Rainer
name: Rohlmann, Friederike
name: Dreyhaupt, Jens
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Biometrie
subject: 610 Medical sciences; Medicine

description: Einleitung: Die randomisierte kontrollierte klinische Studie wird in der Fachliteratur als „Goldstandard“ der klinischen Forschung bezeichnet. Randomisierung bedeutet die zufällige, also unvorhersehbare Zuteilung von Patienten zu den einzelnen Behandlungen und zielt damit bezüglich[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
Additional file 3 of Soluble Periostin is a potential surveillance biomarker for early and long-term response to chemotherapy in advanced breast cancer
Creators: name: Jia, Li
name: Hu, Wenwei
name: Yan, Xu
name: Shao, Jie
name: Guo, Yuhong
name: Zhang, Aimin
name: Yu, Lianzi
name: Zhou, Yunli
name: Li, Yueguo
name: Ren, Li
name: Dong, Dong
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 3: Dynamics of the three markers in longitudinal cases at time-points C0, C2 and C4. Dynamics of the three markers in longitudinal cases annotated with the tumor early response status to chemotherapy at time-points C0, C2 and C4. Representation of individual markers, A: POSTN, B: CA15-3, C: CEA. n = 58.
sj-docx-1-sgo-10.1177_21582440231178796 – Supplemental material for Word Retrieval After the 80s: Evidence From Specific and Multiple Words Naming Tasks
Creators: name: Rojas, Carlos
name: Riffo, Bernardo
name: Guerra, Ernesto
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-sgo-10.1177_21582440231178796 for Word Retrieval After the 80s: Evidence From Specific and Multiple Words Naming Tasks by Carlos Rojas, Bernardo Riffo and Ernesto Guerra in SAGE Open
title: Hemerobie der Wälder im Biosphärenpark Wienerwald
Creators: name: Mayrhofer, Simone
Year: 2009

description: Das Konzept der Hemerobie gilt als Maß zur Beschreibung des Kultureinflusses. Die MAB-Studie „Hemerobie österreichischer Waldökosysteme“ lieferte 1998 erstmals fundierte Kenntnisse über den Zustand der Wälder. Im Rahmen der vorliegenden Arbeit wurde dieses Konzept erneut aufgegriffen und eine Hemerobiestudie im niederösterreichischen Teil des Biosphärenparks Wienerwald auf Flächen der Österreichischen Bundesforste durchgeführt. Um die Vergleichbarkeit zu gewährleisten basiert die gesamte Methodik von der Felderhebung bis zur Hemerobiebewertung auf der MAB-Hemerobiestudie. Somit umfasst die Felderhebung die Aufnahme von Vegetationsdaten, bestandesstrukturelle Kriterien, Hemerobiekriterien und Standortsdaten. Bei der nachfolgenden Auswertung wird ein standardisiertes Bewertungsverfahren, welches die einzelnen Hemerobiekriterien gewichtet und durch verschiedene Verknüpfungsmethoden zu einem Gesamthemerobiewert aggregiert, angewendet. Ergebnisse dieser Arbeit sind eine vegetationsökologische Auswertung, eine Hemerobiebewertung und ein Vergleich zur MAB-Hemerobiesudie 1998 im Untersuchungsgebiet. Weiters soll eine ausführliche Diskussion einen Beitrag für künftige Monitoringstudien liefern.
sj-docx-1-chi-10.1177_17423953231174928 - Supplemental material for Resilience-enhancing interventions for family caregivers: A systematic review
Creators: name: Chi, Nai-Ching
name: Han, Soojeong
name: Lin, Shih-Yin
name: Fu, Ying-Kai
name: Zhu, Zilin
name: Nakad, Lynn
name: Demiris, George
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111702 Aged Health Care
subject: 110203 Respiratory Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-chi-10.1177_17423953231174928 for Resilience-enhancing interventions for family caregivers: A systematic review by Nai-Ching Chi, Soojeong Han, Shih-Yin Lin, Ying-Kai Fu, Zilin Zhu, Lynn Nakad and George Demiris in Chronic Illness
The mathematical epidemiology of human babesiosis in the north-eastern united states
Creators: name: Dunn, Jessica
Publisher: name: RMIT University
Year: 2024

description: Human babesiosis, spread by the Babesia microti pathogen, is an emerging vector-borne disease transmitted by the Ixodes scapularis tick in the United States. The number of babesiosis cases has been increasing leading to the classification as an “emerging health risk' by the Center for Disease Control. The reasons for emergence remain largely unknown.

This thesis presents multi-host, multi-pathogen mechanistic models that explain the zoonotic emergence and persistence of human babesiosis and the Babesia microti pathogen in the United States. A model for the basic reproduction number,R0, and a compartment-type model, combine the seasonal dynamics of tick phenology and within host dynamics in the vertebrate host to identify the key factors that determine emergence and persistence of the Babesia microti pathogen and hence human Babesiosis.

It is found that survival of the immature life-stage of the Ixodes scapularis tick, the probability of feeding on the primary vertebrate host (the white-footed mouse, Peromyscus leucopus) and interactions among pathogens, particularly coinfection with Borrelia burgdorferi the causative agent of Lyme disease, in multiply infected hosts can strongly influence emergence. Successful transmission of Babesia microti from one generation of ticks to the next is linked to overlap between the host-seeking activities of the larval and nymphal life-stages of the tick vector, and co-aggregation of these life-stages on white-footed mouse. This contrasts with other vector-borne pathogens where it is typically the abundance of the vector or host, the vector-to-host ratio or the biting rate that are the factors which determine conditions for emergence.

The mechanistic models derived in this work are transparent and almost all parameters can be measured directly by laboratory or field studies. Such data are used in this thesis to define ecological conditions for the emergence of Babesia microti and to explore the variation between an island site and a mainland site in the north-eastern United States.
Instantaneous actual motion estimation with a single high-resolution radar sensor
Creators: name: Schlichenmaier, Johannes
name: Yan, Leping
name: Stolz, Martin
name: Waldschmidt, Christian
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Automotive Radar
subject: Contour Estimation
subject: Motion Estimation
subject: Yaw Rate Estimation
subject: DDC 620 / Engineering & allied operations
subject: Radar in navigation
subject: Bordradar

description: Future high-resolution radars enable new functionalities in advanced driver assistance systems, relying on fast and reliable extraction of properties of vehicles on the road. A critical property for the prediction of trajectories and the assessment of potentially dangerous situations is that of the actual motion - the velocity vector and yaw rate - of observed objects. In this paper, an approach to distinguish linear from non-linear motions as well as estimating the yaw rate using only a single radar sensor is presented and evaluated via measurements.
Effects of Inertial Load on Sagittal Plane Kinematics During Flywheel-Based Resistance Training Squats
Creators: name: Worcester, Katherine Sara
Publisher: name: University of Kentucky Libraries
Year: 2018

description: Abstract:
Background: Training to increase muscular power is essential for improving athletic performance in most sports. Weight training (WT) is a common means for training muscular power. Another modality, flywheel resistance training (FRT), may be superior for improving muscular power. However, few studies have examined if FRT is kinematically similar to WT, or if FRT kinematics change with increasing inertial load. The purposes of this study were to determine how sagittal plane joint kinematics are affected by increasing inertial load during FRT squats, and to determine how FRT squat joint kinematics compare to WT squat joint kinematics.
Methods: Subjects (n=9) completed three visits for this study. On the first visit subjects completed squat 1 repetition maximum (1RM) testing. The second visit served as a full FRT familiarization session in which subjects performed one set of 5 maximal effort FRT squats at each inertial load (0.050, 0.075, and 0.100 kgm2). On the third visit, subjects were videoed in the sagittal plane while performing the FRT squat protocol. Subjects then completed 5 maximal velocity repetitions of WT squats with the barbell loaded according to the Kansas Squat Test (KST) protocol. Kinematic differences between inertial loads were determined via 1-way repeated measures ANOVAS while differences between FRT and WT were determined with paired T-tests.
Results: There were no differences in peak sagittal plane knee, trunk-hip, trunk (absolute) or ankle angles between inertial loads. Peak and mean joint angular velocities decreased with increasing inertial loads at the knee and trunk-hip. Mean joint angular velocities decreased at the ankle with increasing inertial loads, while peak and mean trunk (absolute) angular velocities were unaffected. No statistical analyses were conducted for FRT and WT comparison as not enough subjects met the criteria (n=3).
Conclusions: Sagittal plane joint kinematics are largely maintained despite increasing inertial load during FRT squats. Lower extremity joint angular velocities decreased with increasing inertial load. If training for muscular power and knee extensor velocity is the goal, then the inertia of 0.050 kgm2 is most suitable.
Katherine Worcester's ORCID ID: https://orcid.org/0000-0002-0768-3962
Copyright: © Katherine Sara Worcester 2018
title: Optimal sample size allocation and go/no-go decision rules for phase II/III programs where several phase III trials with multiple endpoints are performed
Creators: name: Preussler, Stella
name: Kieser, Meinhard
name: Kirchner, Marietta
Publisher: name: German Medical Science GMS Publishing House
Year: 2017
Subjects: subject: Biometrie
subject: 610 Medical sciences; Medicine

description: Introduction: The conduct of phase II and III programs is costly, time consuming and, due to high failure rates in late development stages, risky. As the go/no-go decision and the sample size chosen for phase III are based on the results observed in phase II, there is a strong connection between[for full text, please go to the a.m. URL]
description: 62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
Additional file 4 of Soluble Periostin is a potential surveillance biomarker for early and long-term response to chemotherapy in advanced breast cancer
Creators: name: Jia, Li
name: Hu, Wenwei
name: Yan, Xu
name: Shao, Jie
name: Guo, Yuhong
name: Zhang, Aimin
name: Yu, Lianzi
name: Zhou, Yunli
name: Li, Yueguo
name: Ren, Li
name: Dong, Dong
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 4: This paper presents a consistent frequency comparison of POSTN, CA15-3, and CEA, both individually and in combination, in cases with a partial response. The combination of CA15-3 and CEA, as well as the combination of three markers, is considered consistent as long as at least one marker exhibits a consistent change.
Psychopathological symptoms and gaming motives in disordered gaming : a psychometric comparison between the WHO and APA diagnostic frameworks
Creators: name: Montag, Christian
name: Schivinski, Bruno
name: Sariyska, Rayna
name: Kannen, Christopher
name: Demetrovics, Zsolt
name: Pontes, Halley M.
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Gaming disorder
subject: Internet gaming disorder
subject: World Health Organization
subject: American Psychiatric Association
subject: DDC 150 / Psychology
subject: Internet games
subject: Internet addicts
subject: Video games
subject: Internet
subject: Behavior, Addictive
subject: Spielsucht
subject: Videospiel

description: Background: ‘Gaming Disorder’ (GD) has received increased medical attention and o cial recognition from both the American Psychiatric Association (APA) and the World Health Organization (WHO). Although these two medical organizations have independently developed promising clinical diagnostic frameworks to assess disordered gaming, little is known about how these frameworks compare at di erent psychometric levels in terms of producing consistent outcomes in the assessment of GD. Methods: A sample of 1429 German gamers (Meanage = 29.74 years; SD = 12.37 years) completed an online survey including measures on di erent psychopathological symptoms (depression, loneliness and attention problems), gaming motives and disordered gaming according to the WHO and APA frameworks. Results: The findings suggest the existence of minor discrepancies in the estimation of prevalence rates of GD according among the two frameworks. Nevertheless, both diagnostic frameworks are fairly consistent in the psychometric prediction of GD in relation to gaming motives and psychopathological symptoms. The findings underscore the role of key gaming motives as risk factors and protective factors across both diagnostic frameworks. Finally, the study provides support for the WHO diagnostic framework for GD and its measurement with the German Gaming Disorder Test (GDT). The findings and their implications are further discussed in terms of clinical relevance.
Poster: Network message field type recognition
Creators: name: Kleber, Stephan
name: Kargl, Frank
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Protocol testing and verification
subject: DDC 004 / Data processing & computer science
subject: Electronic data processing; Backup processing alternatives
subject: IPSec (Computer network protocol)
subject: Computer networks
subject: Computer network protocols
subject: Evaluation
subject: Cluster analysis
subject: Computer networks; Security measures
subject: Datensicherung
subject: IPSec
subject: Datennetz
subject: Evaluation
subject: Computersicherheit
subject: Cluster-Analyse

description: Existing approaches to reverse engineer network protocols based on traffic traces lack comprehensive methods to determine the data type, e. g. float, timestamp, or addresses, of segments in messages of binary protocols. We propose a novel method for the analysis of unknown protocol messages to reveal the data types contained in these messages. Therefore, we split messages into segments of bytes and interpret these as vectors of byte values. Based on the vector interpretation, we can determine similarities and characteristics of specific data types. These can be used to classify segments into clusters of the same type and to identify their data type for previously trained data types. We performed first evaluations of different applications of our method that show promising results up the a data-type-recognition precision of 100 %.