cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER
Creators: name: Perkovic V
name: Rossing P
name: Wolthers B
name: Mann J.F.E
name: Bain S.C
name: Rasmussen Sø
name: Mahaffey K.W
name: Idorn T
name: Zinman B
name: Nauck M.A
name: Shaman A.M
name: Buse J.B
name: Bakris G.L
Publisher: name: Lippincott Williams and Wilkins
Year: 2022

description: Background: We assessed the effect of once-weekly semaglutide and once-daily liraglutide on kidney outcomes in type 2 diabetes. Methods: Pooled (n=12 637) and by-trial data from SUSTAIN 6 (Trial to Evaluate Cardiovascular and Other Long-Term Outcomes With Semaglutide in Subjects With Type 2 Diabetes; n=3297) and LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results; n=9340) were assessed for albuminuria change, annual slope of estimated glomerular filtration rate (eGFR) change, and time to persistent eGFR reduction (30%, 40%, 50%, and 57%) from baseline. Results: The median follow-up durations were 2.1 years for SUSTAIN 6 and 3.8 years for LEADER. In the pooled analysis, semaglutide/liraglutide lowered albuminuria from baseline to 2 years after randomization by 24% versus placebo (95% CI, 20%-27%; P<0.001). Significant reductions were also observed in by-trial data analyses (P<0.001 for all), the largest being with semaglutide 1.0 mg (33% [95% CI, 24%-40%]; P<0.001) at 2 years. With semaglutide 1.0 mg and liraglutide, eGFR slope decline was significantly slowed by 0.87 and 0.26 mL/min/1.73 m2/y (P<0.0001 and P<0.001), respectively, versus placebo. Effects appeared larger in patients with baseline eGFR <60 versus ≥60 mL/min/1.73 m2(Pinteraction=0.06 and 0.008 for semaglutide 1.0 mg and liraglutide, respectively). Semaglutide/liraglutide significantly lowered risk of persistent 40% and 50% eGFR reductions versus placebo (hazard ratio [HR], 0.86 [95% CI, 0.75-0.99]; P=0.039 and HR, 0.80 [95% CI, 0.66-0.97]; P=0.023, respectively). Similar, nonsignificant, directional results were observed for 30% and 57% eGFR reductions (HR, 0.92 [95% CI, 0.84-1.02]; P=0.10 and HR, 0.89 [95% CI, 0.69-1.13]; P=0.34). In patients with baseline eGFR 30 to <60 mL/min/1.73 m2, the likelihood of persistent reduction for all thresholds was increased, ranging from HR 0.71 for 30% reduction (95% CI, 0.59-0.85; P=0.0003, Pinteraction=0.017) to 0.54 for 57% reduction (95% CI, 0.36-0.81; P=0.003, Pinteraction=0.035). Conclusions: In patients with type 2 diabetes, semaglutide/liraglutide offered kidney-protective effects, which appeared more pronounced in patients with preexisting chronic kidney disease.
Statistical mechanics of a correlated energy landscape model for protein folding funnels
Creators: name: Plotkin, Steven S.
name: Wang, Jin
name: Wolynes, Peter G.
Publisher: name: arXiv
Year: 1996
Subjects: subject: Condensed Matter (cond-mat)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Energetic correlations due to polymeric constraints and the locality of interactions, in conjunction with the apriori specification of the existence of a particularly low energy state, provides a method of introducing the aspect of minimal frustration to the energy landscapes of random heteropolymers. The resulting funnelled landscape exhibits both a phase transition from a molten globule to a folded state, and the heteropolymeric glass transition in the globular state. We model the folding transition in the self-averaging regime, which together with a simple theory of collapse allows us to depict folding as a double-well free energy surface in terms of suitable reaction coordinates. Observed trends in barrier positions and heights with protein sequence length, stability, and temperature are explained within the context of the model. We also discuss the new physics which arises from the introduction of explicitly cooperative many-body interactions, as might arise from side-chain packing and non-additive hydrophobic forces. Denaturation curves similar to those seen in simulations are predicted from the model.
description: 15 pages,submitted to J. Chem. Phys
Effectiveness of vaccination mandates in improving uptake of COVID-19 vaccines in the USA
Creators: name: Schwartz J.L
name: Benjamin R.M
name: Hotez P.J.
name: Brewer N.T
name: Callaghan T
name: Clinton C
name: Elharake J.A
name: Sharfstein J.M
name: Carpiano R.M
name: Omer S.B
name: Caplan A
name: Flowers L.C
name: DiResta R
name: Salmon D.A
name: Opel D.J
name: Lakshmanan R.
name: Buttenheim A.M
name: Galvani A.P
name: Maldonado Y.A
name: Mello M.M
Publisher: name: Elsevier B.V.
Year: 2022

description: Many high-income countries have rapidly pivoted from hard decisions about who may receive COVID-19 vaccines, due to shortages, to equally hard decisions about who must receive them. As lasting containment of COVID-19 remains elusive, many nations—from Costa Rica, to Austria, to Turkmenistan—are turning to vaccination mandates of various kinds. Mandates, however, are controversial in many countries. Austria’s proposed mandate for adults, for example, provoked mass protests. Some objectors argue mandates represent undue encroachment on individual liberty. Some other objectors maintain that mandates will not be an effective policy for COVID-19 because many individuals will seek to evade them, and mandates might erode support for other public health measures such as mask wearing.
Quantum fluctuations and the c-axis optical conductivity of High-T_c Superconductors
Creators: name: Ioffe, L. B.
name: Millis, A. J.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A theory of the frequency dependence of the interplane conductivity of a strongly anisotropic superconductor is presented. The form of the conductivity is shown to be a sensitive probe of the strength of quantum and thermal fluctuations of the phase of the superconducting order parameter. The temperature dependence of the superfluid stiffness and of the form of the absorbtion at frequencies of the order of twice the superconducting gap is shown to depend on the interplay between superconducting pairing, phase coherence and the mechanism by which electrons are scattered. Measurements of the c-axis conductivity of high-T_c superconductors are interpreted in terms of the theory.
description: 12 pages, 5 figures. The figures are corrected and improved
Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: Design and baseline characteristics of SOUL, a randomized trial
Creators: name: Engelmann M.D.M
name: Hovingh G.K
name: Inzucchi S.E
name: Ripa M.S
name: Mann J.F.E
name: Brown-Frandsen K
name: Mulvagh S.L
name: Gislum M
name: Busui R.P
name: Marx N
name: Poulter N
name: Deanfield J
name: McGuire D.K
name: Buse J.B
Publisher: name: John Wiley and Sons Inc
Year: 2023

description: Aim: To describe the design of the SOUL trial (Semaglutide cardiOvascular oUtcomes triaL) and the baseline clinical data of its participants. Materials and methods: In SOUL, the effects of oral semaglutide, the first oral glucagon-like peptide-1 receptor agonist, on the risk of cardiovascular (CV) events in individuals with type 2 diabetes and established atherosclerotic CV disease (ASCVD) and/or chronic kidney disease (CKD) will be assessed. SOUL is a randomized, double-blind, parallel-group, placebo-controlled CV outcomes trial comparing oral semaglutide (14 mg once daily) with placebo, both in addition to standard of care, in individuals aged ≥50 years with type 2 diabetes and evidence of ASCVD (coronary artery disease [CAD], cerebrovascular disease, symptomatic peripheral arterial disease [PAD]) and/or CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2). The primary outcome is time from randomization to first occurrence of a major adverse CV event (MACE; a composite of CV death, nonfatal myocardial infarction or nonfatal stroke). This event-driven trial will continue until 1225 first adjudication-confirmed MACEs have occurred. Enrolment has been completed. Results: Overall, 9650 participants were enrolled between June 17, 2019 and March 24, 2021 (men 71.1%, White ethnicity 68.9%, mean age 66.1 years, diabetes duration 15.4 years, body mass index 31.1 kg/m2, glycated haemoglobin 63.5 mmol/mol [8.0%]). The most frequently used antihyperglycaemic medications at baseline were metformin (75.7%), insulin and insulin analogues (50.5%), sulphonylureas (29.1%), sodium-glucose cotransporter-2 inhibitors (26.7%) and dipeptidyl peptidase-4 inhibitors (23.0%). At randomization, 70.7% of participants had CAD, 42.3% had CKD, 21.1% had cerebrovascular disease and 15.7% had symptomatic PAD (categories not mutually exclusive). Prevalent heart failure was reported in 23.0% of participants. Conclusion: SOUL will provide evidence regarding the CV effects of oral semaglutide in individuals with type 2 diabetes and established ASCVD and/or CKD.
Glossoscolecidae
Creators: name: Dudas, Rafaela T.
name: Tavares, Alan A. T.
name: Ercole, Caique
name: De Lara, Brunna L.
name: Carlos, Esthefany Da S.
name: Torres, Julia L. M.
name: Smokanit, Manoela
name: Guaranha, Raquel M.
name: Brown, George G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Crassiclitellata
Glossoscolecidae

description: Glossoscolecidae (juveniles)   BRPR1627, 1 individual, in 0 to 20 cm soil depth in grass lawn in Universidade Positivo, Curitiba — PR (-25.448590 -49.356999, 949 m. a.s.l.), February 2019, A.A. T. Tavares, B.L. de Lara, C. Ercole, E. da S. Carlos, M.L.C. Bartz, R. T. Dudas colls.
description: Published as part of Dudas, Rafaela T., Tavares, Alan A. T., Ercole, Caique, De Lara, Brunna L., Carlos, Esthefany Da S., Torres, Julia L. M., Smokanit, Manoela, Guaranha, Raquel M. & Brown, George G., 2023, Urban green areas as earthworm species maintainers in Curitiba, Paraná, Brazil, pp. 336-346 in Zootaxa 5255 (1) on page 339, DOI: 10.11646/zootaxa.5255.1.27, http://zenodo.org/record/7744988
title: IL-34 in the pathogenesis of human rheumatoid and lupus arthritis
Creators: name: Weinmann-Menke, Julia
name: Meineck, Myriam
name: Cavagna, Lorenzo
name: Brochhausen, Christoph
name: Weinmann, Arndt
name: Moeckel, Tamara
name: Schwarting, Andreas
name: Kelley, Vicki
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: While myeloid cells are abundant in lupus arthritis (LA) and rheumatoid arthritis (RA), based on clinical presentation LA and RA are considered distinct diseases. As imaging improves, it becomes increasingly clear that LA in SLE patients also leads to destruction of the joint and connective[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Distinguishing general relativity from Chern-Simons gravity using gravitational wave polarizations
Creators: name: Bhattacharyya, Soham
name: Shankaranarayanan, S.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Quasi-normal modes (QNMs) uniquely characterize the final black-hole. Till now, only the QNM frequency and damping time are used to test General relativity. In this work, we show explicitly that another property of the QNMs --- their polarization --- can be a reliable tool for probing gravity. We provide a consistent test for General relativity by considering Chern-Simons gravity. Distinguishing Chern-Simons gravity from General relativity using only template matching is highly challenging. Thus a parameter that can differentiate between Chern-Simons gravity and GR will be a suitable candidate for any modified theories of gravity. We discuss the implications of our result for the future gravitational wave detectors.
description: 17 pages, version as accepted in Physical Review D
title: Availability of a sports dietitian may lead to improved performance and recovery of NCAA division I baseball athletes
Creators: name: Hull, Michael V.
name: Neddo, Jonathan
name: Jagim, Andrew R.
name: Oliver, Jonathan M
name: Greenwood, Mike
name: Jones, Margaret T.
Publisher: name: Journal of the International Society of Sports Nutrition
Year: 2017

description: Background: The purpose was to survey dietary habits (DH) and nutrient timing (NT) practices of baseball studentathletes (mean ± SD; 20.7 ± 1.4 yr.) from three NCAA Division I institutions, and examine the effect of a sports dietitian (SD) in regard to nutrition practices. Methods: Descriptive statistics and Pearson X2 analyses were run. Responses on 10 DH and 5 NT items differed (p ≤ 0.10) between athletes who sought dietary planning from a SD (n = 36) versus those who consulted a strength and conditioning coach (SCC, n = 42). Results: In regard to DH items, the SD group found it easier to eat before activity (92% vs. 71%, p = 0.03), did not consume fast food (31% vs. 14%, p = 0.02), caffeinated beverages (57% vs. 46%, p = 0.02), or soda (56% vs. 37%, p = 0.10), prepared their own meals more often (86% vs. 73%, p = 0.07), and took daily multi-vitamins (56% vs. 32%, p = 0.02). The SCC group ate more at burger locations (21% vs. 6%, p = 0.02). In regard to NT items, the SD group ate breakfast before training/lifting sessions (67% vs. 37%, p = 0.02), and had post-workout nutrition options provided (61% vs. 27%, p = 0.01). The SCC group reported pre-competition meals of fast food (58% vs. 45%, p = 0. 01), and sport coaches who were less aware of healthy food options (39% vs. 65%, p = 0.05). Conclusions: The SD is as a valuable asset to an intercollegiate athletics program. In the current study, athletes from the SD group consumed less high calorie/low nutrient dense items, ate before exercise, and consumed healthier options post-exercise. The presence of a SD was linked to provision of healthier food options during team trips. The evidence-based eating strategies and dietary plan provided by a SD may lead to improved performance and recovery
Compact Jacobi matrices: from Stieltjes to Krein and M(a,b)
Creators: name: Van Assche, Walter
Publisher: name: arXiv
Year: 1995
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: In a note at the end of his paper {\it Recherches sur les fractions continues}, Stieltjes gave a necessary and sufficient condition when a continued fraction is represented by a meromorphic function. This result is related to the study of compact Jacobi matrices. We indicate how this notion was developped and used since Stieltjes, with special attention to the results by M. G. Krein. We also pay attention to the perturbation of a constant Jacobi matrix by a compact Jacobi matrix, work which basically started with Blumenthal in 1889 and which now is known as the theory for the class $M(a,b)$.
Filling Control of the Mott Insulator Ca2RuO4
Creators: name: Fukazawa, Hideto
name: Maeno, Yoshiteru
Publisher: name: arXiv
Year: 2000
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have grown single crystals of electron doping system Ca2-xLaxRuO4 (0.00 <= x <= 0.20) by a floating zone method. The first order metal/non-metal transition and canted antiferromagnetic ordering occur for 0.00 < x < 0.15, similar to those in the bandwidth controlled system Ca2-xSrxRuO4 (CSRO). However, comparing with CSRO, we found a rather different metallic ground state adjacent to the non-metallic ground state with canted antiferromagnetic order. Instead of short-range antiferromagnetic correlation found in CSRO (0.20 <= x < 0.50), the metallic ground state of the present system is characterized by strong ferromagnetic correlation.
description: 8 pages, 8 figures (eps), submitted to J. Phys. Soc. Jpn
title: The 3D human-based in vitro arthritic joint model
Creators: name: Damerau, Alexandra
name: Lang, Annemarie
name: Pfeiffenberger, Moritz
name: Buttgereit, Frank
name: Gaber, Timo
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Our ultimate goal is to study the influence and efficacy of potential drug candidates in an experimental setting of arthritis. Therefore, we aim to develop a valid human in vitro 3D joint model mimicking features of joint inflammation by applying inflammatory conditions namely immune cells[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Secluded Dark Matter in light of the Cherenkov Telescope Array (CTA)
Creators: name: Siqueira, Clarissa
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Secluded dark matter is one of the most popular dark matter models, where dark matter annihilations go into particles that belong to a dark sector. An interesting way to probe such models is via indirect detection. In particular, gamma-ray observations are rather promising. Taking into account $1\%$ level of systematics, in this work we show that the Cherenkov Telescope Array (CTA) will place the most stringent bounds on the dark matter annihilation cross section, surpassing existing probes based on H.E.S.S., Fermi-LAT, and Planck data, for dark matter masses above $400$ GeV, independently of the channel and choosing the Einasto profile. We consider scenarios of secluded annihilations into leptophilic, leptophobic scalars and Higgs-like particles being able to exclude an annihilation cross section of $1.7 \times 10^{-25}$ cm$^3 \,$s$^{-1}$ for $m_{DM}=5000$ GeV, for $ϕ\to e^+e^-$ channel, for example, exceeding the current limits by one order of magnitude.
description: 9 pages, 14 figures. Matches version published in PLB
Low Temperature AC Conductivity in BSCCO (2212)
Creators: name: Corson, J.
name: Mallozzi, R.
name: Orenstein, J.
name: Eckstein, J. N.
name: Bozovic, I.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report measurements of anamolously large dissipative conductivities in BiSrCaCuO(2212) at low temperatures. We have measured the complex conductivity of BSCCO thin films at 100-600 GHz as a function of doping from the underdoped to the overdoped state. At low temperatures there exists a residual dissipative conductivity which scales with the T=0 superfluid density as the doping is varied. This residual dissipative conductivity is larger than the possible contribution from a thermal population of quasiparticles at the d-wave gap nodes.
description: Submitted to the Proceedings of the 22nd International Low Temperature Physics Conference. To be published in Physica B (http://www.elsevier.nl/locate/physb); 2 Pages with 2 Figures
Ocnerodrilidae
Creators: name: Dudas, Rafaela T.
name: Tavares, Alan A. T.
name: Ercole, Caique
name: De Lara, Brunna L.
name: Carlos, Esthefany Da S.
name: Torres, Julia L. M.
name: Smokanit, Manoela
name: Guaranha, Raquel M.
name: Brown, George G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Ocnerodrilidae

description: Ocnerodrilidae sp.43   BRPR1727, 20 individuals, in 0 to 20 soil depth in grass lawn in Universidade Positivo, Curitiba - PR (-25.445700 - 49.361800, 949 m. a.s.l.), March 2018, R.M. Guaranha, M. Smokanit, J.L.M. Torres, M.L.C. Bartz colls. BRPR1708, 15 individuals, in 0 to 20 soil depth in grass lawn in Universidade Positivo, Curitiba – PR (-25.448194 -49.356076, 949 m. a.s.l.), February 2019, A.A. T. Tavares, B.L. de Lara, C. Ercole, E. da S. Carlos, M.L.C. Bartz, R. T. Dudas colls. BRPR1655, BRPR1658, BRPR1708 and BRPR1727, 30 individuals, in 0 to 20 soil depth in grass lawn in Universidade Positivo, Curitiba – PR (-25.448194 -49.356076, 949 m. a.s.l.), June 2019, A.A. T. Tavares, B.L. de Lara, C. Ercole, E. da S. Carlos, M.L.C. Bartz, R. T. Dudas colls. BRPR1680, 2 individuals, in 0 to 20 soil depth in grass lawn in Casa Verde, Curitiba – PR (-25.456633 -49.373330, 926 m. a.s.l.), February 2019, A.A. T. Tavares, B.L. de Lara, C. Ercole, E. da S. Carlos, M.L.C. Bartz, R. T. Dudas colls.
description: Published as part of Dudas, Rafaela T., Tavares, Alan A. T., Ercole, Caique, De Lara, Brunna L., Carlos, Esthefany Da S., Torres, Julia L. M., Smokanit, Manoela, Guaranha, Raquel M. & Brown, George G., 2023, Urban green areas as earthworm species maintainers in Curitiba, Paraná, Brazil, pp. 336-346 in Zootaxa 5255 (1) on page 340, DOI: 10.11646/zootaxa.5255.1.27, http://zenodo.org/record/7744988
Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial
Creators: name: Gabery S
name: Christiansen E
name: Buse J.B
name: Pedersen S.D
name: Bardtrum L
name: Knop F.K
name: Aroda V.R
name: Aberle J
Publisher: name: Elsevier B.V.
Year: 2023

description: Background: Once-daily oral semaglutide is an effective type 2 diabetes treatment. We aimed to investigate a new formulation of oral semaglutide at higher investigational doses versus the approved 14 mg dose in adults with inadequately controlled type 2 diabetes. Methods: This global, multicentre, randomised, double-blind, phase 3b trial, carried out at 177 sites in 14 countries, enrolled adults with type 2 diabetes, glycated haemoglobin (HbA1c) 8·0−10·5% (64−91 mmol/mol), a BMI of 25·0 kg/m2 or greater, receiving stable daily doses of one to three oral glucose-lowering drugs. Participants were randomly assigned (1:1:1), by means of an interactive web response system, to once-daily oral semaglutide 14 mg, 25 mg, or 50 mg for 68 weeks. Investigators, site personnel, trial participants, and trial sponsor staff were masked to dose assignment throughout the trial. The primary endpoint was change in HbA1c from baseline to week 52, evaluated with a treatment policy estimand in the intention-to-treat population. Safety was assessed in all participants who received at least one dose of trial drug. This trial is registered with ClinicalTrials.gov, NCT04707469, and the European Clinical Trials register, EudraCT 2020-000299-39, and is complete. Findings: Between Jan 15 and Sept 29, 2021, of 2294 people screened, 1606 (n=936 [58·3%] male; n=670 [41·7%] female; mean [SD] age 58·2 [10·8] years) received oral semaglutide 14 mg (n=536), 25 mg (n=535), or 50 mg (n=535). At baseline, mean (SD) HbA1c was 9·0% (0·8; 74·4 mmol/L [SD 8·3]) and mean bodyweight was 96·4 kg (21·6). Mean changes (SE) in HbA1c at week 52 were −1·5 percentage points (SE 0·05) with oral semaglutide 14 mg, −1·8 percentage points (0·06) with 25 mg (estimated treatment difference [ETD] −0·27, 95% CI −0·42 to −0·12; p=0·0006), and −2·0 percentage points (0·06) with 50 mg (ETD −0·53, −0·68 to −0·38; p<0·0001). Adverse events were reported by 404 (76%) participants in the oral semaglutide 14 mg group, 422 (79%) in the 25 mg group, and 428 (80%) in the 50 mg group. Gastrointestinal disorders, which were mostly mild to moderate, occurred more frequently with oral semaglutide 25 mg and 50 mg than with 14 mg. Ten deaths occurred during the trial; none were judged to be treatment related. Interpretation: Oral semaglutide 25 mg and 50 mg were superior to 14 mg in reducing HbA1c and bodyweight in adults with inadequately controlled type 2 diabetes. No new safety concerns were identified. Funding: Novo Nordisk.
title: Examination of Personal Motivations of Leisure Choices in the Social Media Era
Creators: name: Workman, Patrick
Publisher: name: George Mason University
Year: 2017
Subjects: subject: Leisure
subject: Recreations
subject: E-based literature
subject: Social media
subject: Motivations
subject: Interpersonal interactions

description: In 2004, the world began an ever growing relationship and interactions with social media. Social media has shown not to be a short lived fad, but a trend with an extremely high usage rate. Company valuations of Facebook, Twitter and Snapchat are in the billions. Discretionary leisure time has shifted from forms of more traditional leisure to e-based activities. Staples of recreation such as sports, indoor and outdoor fitness, and traditional programs are often bypassed by social media and online interactive gaming by participants who are finding new mediums for interaction. Recreation agencies, both private and public, are working to discover the best ways to integrate technology and keep up with user’s need for this new idea of a customized society and emersion in continuing technological trends. This mixed methods research examined the user’s involvement in e-based activities and how it may have displaced former leisure practices that are considered more traditional program classifications. The research further studied a person’s need to participate in all leisure activities and the benefits derived from interpersonal interactions as well as how online interactions in certain applications can replicate characteristics of face to face interactions. Also assessed were the integration and effectiveness of technology and adoption of social media usage by recreation agencies. To test the hypothesis that speaks to the changing trends of leisure and the emergence of e-based activities as a major component of a person’s discretionary leisure time, interview surveys were conducted with recreation agency users. Through participant responses and reviewing the need for both interaction and usage of social media and technology as a form of human connectivity; this research postulated users are supplementing and in some cases replacing traditional face to face leisure programming with the use of social media and technology to satisfy their need for interpersonal relations.
title: Integrin α11β1 deficiency affects joint destructions in arthritic hTNFtg mice
Creators: name: Rauwolf, Kerstin Katharina
name: Deichsel, Adrian
name: Beckmann, Denise
name: Hansen, Uwe
name: Kronenberg, Daniel
name: Gullberg, Donald
name: Pap, Thomas
name: Korb-Pap, Adelheid
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Integrins are connectors between the extracellular matrix (ECM) and intracellular signalling pathways involved in the regulation of cellular proliferation, migration, tissue invasion, cytokine and MMP production – key mechanisms leading to joint destruction during rheumatoid arthritis[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Unitary inflaton as decaying dark matter
Creators: name: Choi, Soo-Min
name: Kang, Yoo-Jin
name: Lee, Hyun Min
name: Yamashita, Kimiko
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the inflation model of a singlet scalar field (sigma field) with both quadratic and linear non-minimal couplings where unitarity is ensured up to the Planck scale. We assume that a $Z_2$ symmetry for the sigma field is respected by the scalar potential in Jordan frame but it is broken explicitly by the linear non-minimal coupling due to quantum gravity. We discuss the impacts of the linear non-minimal coupling on various dynamics from inflation to low energy, such as a sizable tensor-to-scalar ratio, a novel reheating process with quartic potential dominance, and suppressed physical parameters in the low energy, etc. In particular, the linear non-minimal coupling leads to the linear couplings of the sigma field to the Standard Model through the trace of the energy-momentum tensor in Einstein frame. Thus, regarding the sigma field as a decaying dark matter, we consider the non-thermal production mechanisms for dark matter from the decays of Higgs and inflaton condensate and show the parameter space that is compatible with the correct relic density and cosmological constraints.
description: 36 pages, 7 figures, v2: minor corrections made and references added, v3: discussion on preheating added, accepted for Journal of High Energy Physics, v4: Lyman-alpha bound included and inflationary predictions refined for perturbative reheating
MPEC 2024-U39 : 2024 UL
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 UL

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Association between cooking patterns and the prevalence of hyperlipidemia in Eastern China
Creators: name: Cui, Bin
name: Yuan, Wen Kai
name: Wang, Linda Dong-Ling
name: Wang, Fu Rong
name: Peng, Jing
name: Ma, Jian Ying
name: Chen, Xiang
name: Xu, Mei Yin
name: Ke, Jun
name: Tian, Yi
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1: Questionnaire
Orbital Liquid in Perovskite Transition-Metal Oxides
Creators: name: Ishihara, Sumio
name: Yamanaka, Masanori
name: Nagaosa, Naoto
Publisher: name: arXiv
Year: 1996
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We study the effects of the degeneracy of the $e_g$ orbitals as well as the double exchange interaction with $t_{2g}$ spins in perovskite transition-metal oxides. In addition to the spin field ${\vec S}_i$, the isospin field ${\vec T}_i$ is introduced to describe the orbital degrees of freedom. The isospin is the quantum dynamical variable, and is represented by the boson with a constraint. The dispersion of this boson is flat along $(π/a,π/a,k_z)$ ($a$: lattice constant) and the other two equivalent directions. This enables the orbital disordered phase down to low temperatures. We interpret some of the anomalous experiments, i.e., optical absorption and d.c. resistivity, in the low temperature ferromagnetic phase of La$_{1-x}$Sr$_x$MnO$_3$ with $x > 0.2$ in terms of this orbital liquid picture.
description: 4 pages, RevTex and 1 Postscript figure
title: Paper: "Oversight and Steering for Effective System Design," 1987
Creators: name: Warfield, John
Publisher: name: George Mason University
Year: 1987
Subjects: subject: Warfield, John N.
subject: System Science
subject: Science of Generic Desigh
subject: Detractors to Effective System Design
subject: Demosophia

description: Manuscript: typescript with table, 13 pgs. 8.5" x 11" (21.6 cm x 29.7 cm
description: This paper suggests that much more emphasis on philosophy, logic, linguistics, psychology and generic design science be included in a curriculum for educating and training more powerful managers and designers than are now in operation. Includes a list of detractors to effective system design and how they can be overcome. Presented at the Annual Meeting of the International Society for General Systems Research, May 21-27, 1988 in St. Louis, Missouri. John N. Warfield Collection 76.41
Evolution of Inhomogeneous Condensates: Self-consistent Variational Approach
Creators: name: Boyanovsky, D.
name: Cooper, F.
name: de Vega, H. J.
name: Sodano, P.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We establish a self-consistent variational framework that allows us to study numerically the non-equilibrium evolution of non-perturbative inhomogeneous field configurations including quantum backreaction effects. After discussing the practical merits and disadvantages of different approaches we provide a closed set of local and renormalizable update equations that determine the dynamical evolution of inhomogeneous condensates and can be implemented numerically. These incorporate self-consistently the backreaction of quantum fluctuations and particle production. This program requires the solution of a self-consistent inhomogeneous problem to provide initial Cauchy data for the inhomogeneous condensates and Green's functions. We provide a simple solvable ansatz for such an initial value problem for the Sine-Gordon and phi^4 quantum field theories in one spatial dimension. We compare exact known results of the Sine Gordon model to this simple ansatz. We also study the linear sigma model in the large N limit in three spatial dimensions as a microscopic model for pion production in ultrarelativistic collisions. We provide a solvable self- consistent ansatz for the initial value problem with cylindrical symmetry. For this case we also obtain a closed set of local and renormalized update equations that can be numerically implemented. A novel phenomenon of spinodal instabilities and pion production arises as a result of a Klein paradox for large amplitude inhomogeneous condensate configurations.
description: Latex file, 44 pages, 3 .eps figures. To appear in Phys. Rev. D. Improved presentation and references added
Relative space-time asymmetries in pion and nucleon production in non-central nucleus-nucleus collisions at high energies
Creators: name: Voloshin, S.
name: Lednicky, R.
name: Panitkin, S.
name: Xu, Nu
Publisher: name: arXiv
Year: 1997
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose to use the ratio of the pion-proton correlation functions evaluated under different conditions to study the relative space-time asymmetries in pion and proton emission (pion and nucleon source relative shifts) in high energy heavy ion collision. We address the question of the non-central collisions, where the sources can be shifted spatially both in the longitudinal and in the transverse directions in the reaction plane. We use the RQMD event generator to illustrate the effect and the technique.
description: RevTex, 4 pages, 3 figures included as eps files
Efficient monolithic all-perovskite tandem solar modules with small cell-to-module derate
Creators: name: Wang K
name: Dai X
name: Zhao L
name: Jiao H
name: Chen B
name: Ni Z
name: Chen S
name: Yu Z
name: Huang J
name: Gao Y
Publisher: name: Nature Research
Year: 2022

description: All-perovskite tandem solar modules are promising to reduce the cost of photovoltaic systems with their high efficiency and solution fabrication, but their sensitivity to air still imposes a great challenge. Here a hot gas-assisted blading method is developed to accelerate the perovskite solidification, forming compact and thick narrow bandgap (NBG) perovskite films. Adding a reduction agent into NBG films followed by a short period of air exposure and a post-fabrication storage surprisingly increases carrier recombination lifetime and enables laser scribing in ambient conditions without obvious loss of device performance. This combination suppresses tin and iodide oxidation and forms a thin SnO2 layer on the NBG film surface. Monolithic all-perovskite tandem solar modules showed a champion efficiency of 21.6% with a 14.3 cm2 aperture area, corresponding to an active area efficiency of 23.0%. The very small cell-to-module derate of 6.5% demonstrates the advantage of a tandem monolithic structure for solar modules.
title: Caffeine impacts inflammatory markers and apoptosis rates in cultured human SLE B-cells in comparison to normal controls
Creators: name: Siekierka-Harreis, Magdalena
name: Schroedter, Madita
name: Brinks, Ralph
name: Chehab, Gamal
name: Richter, Jutta
name: Opgenoorth, Birgit
name: Schneider, Matthias
name: Pongratz, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: The effect of caffeine, an adenosine antagonist, on inflammation and autoimmune condition is poorly elucidated. Inflammation is important to the development of SLE, a chronic, multifaceted autoimmune disease. B-cells play a crucial role in the pathogenesis of SLE. We aimed to investigate[for full text, please go to the a.m. URL]
description: 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
On Gross spaces
Creators: name: Shelah, Saharon
name: Spinas, Otmar
Publisher: name: arXiv
Year: 1995
Subjects: subject: Logic (math.LO)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics

description: A Gross space is a vector space E of infinite dimension over some field F, which is endowed with a symmetric bilinear form Phi:E^2 -> F and has the property that every infinite dimensional subspace U subseteq E satisfies dim U^perp < dim E. Gross spaces over uncountable fields exist (in certain dimensions). The existence of a Gross space over countable or finite fields (in a fixed dimension not above the continuum) is independent of the axioms of ZFC. Here we continue the investigation of Gross spaces. Among other things we show that if the cardinal invariant b equals omega_1 a Gross space in dimension omega_1 exists over every infinite field, and that it is consistent that Gross spaces exist over every infinite field but not over any finite field. We also generalize the notion of a Gross space and construct generalized Gross spaces in ZFC.
A Virgo Environmental Survey Tracing Ionised Gas Emission (VESTIGE).V. Properties of the ionised gas filament of M87
Creators: name: Boselli, A.
name: Fossati, M.
name: Longobardi, A.
name: Consolandi, G.
name: Amram, P.
name: Sun, M.
name: Andreani, P.
name: Boquien, M.
name: Braine, J.
name: Combes, F.
name: Cote, P.
name: Cuillandre, J. C.
name: Duc, P. A.
name: Emsellem, E.
name: Ferrarese, L.
name: Gavazzi, G.
name: Gwyn, S.
name: Hensler, G.
name: Peng, E. W.
name: Plana, H.
name: Roediger, J.
name: Sanchez-Janssen, R.
name: Sarzi, M.
name: Serra, P.
name: Trinchieri, G.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have observed the giant elliptical galaxy M87 during the Virgo Environmental Survey Tracing Galaxy Evolution (VESTIGE), a blind narrow-band Halpha+[NII] imaging survey of the Virgo cluster carried out with MegaCam at the Canada French Hawaii Telescope (CFHT). The deep narrow-band image confirmed the presence of a filament of ionised gas extending up to ~ 3 kpc in the north-western direction and ~ 8 kpc to the south-east, with a couple of plumes of ionised gas, the weakest of which, at ~ 18 kpc from the nucleus, was previously unknown. The analysis of deep optical images taken from the NGVS survey confirms that this gas filament is associated with dust seen in absorption which is now detected up to ~ 2.4 kpc from the nucleus. We have also analysed the physical and kinematical properties of the ionised gas filament using deep IFU MUSE data covering the central 4.8 x 4.8 kpc^2 of the galaxy. The spectroscopic data confirms a perturbed kinematics of the ionised gas, with differences in velocity of ~ 700-800 km s^-1 on scales of < 1 kpc. The analysis of 2D diagnostic diagrams and the observed relationship between the shock-sensitive [OI]/Halpha line ratio and the velocity dispersion of the gas suggest that the gas is shock-ionised.
description: Accepted for publication to Astronomy & Astrophysics
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0094
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0094, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0094, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Efficient sky-blue perovskite light-emitting diodes via photoluminescence enhancement
Creators: name: Zhao J
name: Zhou N
name: Xiao X
name: Yan Y
name: Wang Q
name: Deng Y
name: Moran A
name: Huang J
name: Rudd P
name: Wang X
name: Yang Z
Publisher: name: Nature Research
Year: 2019

description: The efficiencies of green and red perovskite light-emitting diodes (PeLEDs) have been increased close to their theoretical upper limit, while the efficiency of blue PeLEDs is lagging far behind. Here we report enhancing the efficiency of sky-blue PeLEDs by overcoming a major hurdle of low photoluminescence quantum efficiency in wide-bandgap perovskites. Blending phenylethylammonium chloride into cesium lead halide perovskites yields a mixture of two-dimensional and three-dimensional perovskites, which enhances photoluminescence quantum efficiency from 1.1% to 19.8%. Adding yttrium (III) chloride into the mixture further enhances photoluminescence quantum efficiency to 49.7%. Yttrium is found to incorporate into the three-dimensional perovskite grain, while it is still rich at grain boundaries and surfaces. The yttrium on grain surface increases the bandgap of grain shell, which confines the charge carriers inside grains for efficient radiative recombination. Record efficiencies of 11.0% and 4.8% were obtained in sky-blue and blue PeLEDs, respectively.
Additional file 1 of Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
Creators: name: Dandia, Hiren Y.
name: Pillai, Mamatha M.
name: Sharma, Deepak
name: Suvarna, Meghna
name: Dalal, Neha
name: Madhok, Ayush
name: Ingle, Arvind
name: Chiplunkar, Shubhada V.
name: Galande, Sanjeev
name: Tayalia, Prakriti
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Fig. S1 Characterization of matrices. Fig. S2 In vivo cellular infiltration into the matrices. Fig. S3 In vivo compatibility of matrices. Fig. S4 Immobilization of lentiviruses (LVs) on matrices and in vitro transduction studies. Fig. S5 Surgical implantation of matrices for anti-tumor studies. Fig. S6 Effect of anti-tumor therapy on spleen. Fig. S7 Gating strategy to characterize for transduced cells (OVA-TCR+) (a) and helper (CD4+) and cytotoxic (CD8+) T-cells (b) in spleen and inguinal lymph node of tumor bearing mice implanted with matrices loaded with OVA-TCR lentiviruses. Fig. S8 Characterization of programmed cells in spleen and inguinal lymph node. Fig. S9 Characterization of splenocytes for non-specific transduction. Fig. S10 Phenotypic characterization of T-cells infiltrating the tumors. Fig. S11 Phenotypic characterization of immune cells (other than T-cells) infiltrating the tumors. Fig. S12 Quantification of cells infiltrating the tumors, representing percentage of CD3+CD8−(CD4+)OVA-TCR+ cells (a), CD3+CD4+ and CD3+CD8+ cells (b) and CD3+CD4+FOXP3+ Treg cells (c). Table S1 Blood cell markers on day 3 of C57BL/6 mice implanted with PEGDA or PEGDA-PLL implants (n = 3).
Elevated left ventricular end diastolic pressure is associated with increased risk of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention
Creators: name: Dai, X
name: Liu, C
name: Caughey, M.C
name: Smith, Jr., S.C
Publisher: name: Elsevier Ireland Ltd
Year: 2020

description: Aims: To study the correlation between intra-procedural left ventricular end-diastolic pressure (LVEDP) and the development of contrast-induced acute kidney injury (CI-AKI) in patients undergoing percutaneous coronary intervention (PCI). Methods and results: A single center retrospective observational study compared clinical and hemodynamic characteristics of patients who developed post-PCI CI-AKI with those did not. CI-AKI was defined as an absolute increase in serum creatinine ≥0.5 mg/dl or an increase ≥25% from baseline 48–72 h after the administration of contrast medium. Among 1301 consecutive patients who underwent PCI, 125 patients (9.6%) developed CI-AKI. The CI-AKI group had a higher average LVEDP (18.4 ± 8.7 vs 14.4 ± 6.6 mm Hg; p < .0001) and higher prevalence of elevated LVEDP (≥20 mm Hg) than those without CI-AKI (47.2% vs 23.3%, p < .0001). After adjustments, elevated LVEDP remained independently associated with CI-AKI (OR 2.21; 95% CI 1.40–3.50). LVEDP predicted the development of CI-AKI with a receiver operating characteristic area under curve (AUC) of 0.64. The association between elevated LVEDP and the risk of CI-AKI was stronger in patients with reduced ejection fraction (EF ≤ 40%) (OR = 4.08; 95% CI: 1.68–9.91) than those with preserved EF (OR = 1.69; 95% CI: 0.94–3.04) (p value for interaction = .0003). Patients who had LVEDP ≥ 20 mm Hg and LVEF ≤ 40% had a post-PCI incidence rate of developing CI-AKI of 36.5%. Conclusions: Elevated intra-procedural LVEDP (≥20 mm Hg) is independently associated with increased risk of CI-AKI for patients undergoing cardiac catheterization and PCI, especially in the setting of reduced LVEF (≤40%).