cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Equivalency and practice effects of alternative versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS)
Creators: name: Costello, Emmet
name: Lonergan, Katie
name: Madden, Caoifa
name: O’Sullivan, Meadhbh
name: Mays, Iain
name: Heverin, Mark
name: Pinto-Grau, Marta
name: Hardiman, Orla
name: Pender, Niall
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Mental Health

description: To examine the equivalency of ECAS versions A, B, and C in an Irish cohort, and to examine potential practice effects, 236 healthy controls were recruited through the Irish ALS control database. One hundred and seventy-six (176) controls completed ECAS version A, B, or C. Separately, 60 controls completed all three versions (A–B–C), consecutively, four months apart. TOST analysis found that ECAS A was equivalent to ECAS B and C. ECAS B and C were not statistically equivalent, however the difference between them was minimal. Participants showed improvement in ECAS performance over time, indicative of practice effects. Significant improvement was observed from time 1 to 2, but not from time 2 to 3. We propose Irish specific reliable change index (RCI) scores that take into consideration practice effects and measurement error. These thresholds will help quantify clinically meaningful cognitive decline in ALS patients, leading to improved quality of care.
Tunable Localization of Light Using Nested Invisible Metasurface Cavities
Creators: name: Cuesta, F. S.
name: Kosulnikov, S.
name: Asadchy, V. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: An invisible cavity is an open resonant device that confines a localized field without producing any scattering outside of the device volume. By exploiting the scatter-less property of such device, it is possible to nest two invisible cavities, as the outer cavity would simply not notice the presence of the inner one, regardless of their relative position. As a result, the position of the inner cavity becomes a means to easily control the field localized inside the cavity and its quality factor. In this paper, we discuss the properties of nested invisible cavities as a simple method to achieve stronger localized fields and high tunable quality factor. Furthermore, we show that in optics, these cavities can be implemented using nanodisk-based dielectric metasurfaces that operate near their electric resonances.
description: 7 pages, 4 figures
PROGRAMA DE LACTANCIA MATERNA EN LA EMPRESA IBM
Creators: name: Molina Delgado, José Renán
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 510502
subject: Medical physics

description: El Programa de Lactancia Materna en la empresa IBI tiene como objetivo promover y apoyar la lactancia materna exclusiva de las madres empleadas, proporcionando un ambiente adecuado y favoreciendo la continuidad de la lactancia durante la jornada laboral. Además, busca cumplir con la normativa vigente relacionada con la lactancia materna en el ámbito laboral.
Asymmetrical lateral ventricular enlargement in Parkinson’s disease
Creators: name: Lewis, M. M.
name: Gouttard, S.
name: Poole, R.
name: Mailman, R. B.
name: Styner, M.
name: Gu, H.
name: Smith, A. B.
name: McKeown, M. J.
name: Zhu, H.
name: Huang, X.
name: Barbero, X.
name: Li, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson’s disease (PD). The current study explored these associations further.
Prediction of Leptonic CP Phase in $A_4$ symmetric model
Creators: name: Kang, Sin Kyu
name: Tanimoto, Morimitsu
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider minimal modifications to tribimaximal (TBM) mixing matrix which accommodate non-zero mixing angle $θ_{13}$ and CP violation. We derive four possible forms for the minimal modifications to TBM mixing in a model with $A_4$ flavor symmetry by incorporating symmetry breaking terms appropriately. We show how possible values of the Dirac-type CP phase $δ_D$ can be predicted with regards to two neutrino mixing angles in the standard parametrization of the neutrino mixing matrix. Carrying out numerical analysis based on the recent updated experimental results for neutrino mixing angles, we predict the values of the CP phase for all possible cases. We also confront our predictions of the CP phase with the updated fit.
description: 15 pages, 3 figures
Equivalency and practice effects of alternative versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS)
Creators: name: Costello, Emmet
name: Lonergan, Katie
name: Madden, Caoifa
name: O’Sullivan, Meadhbh
name: Mays, Iain
name: Heverin, Mark
name: Pinto-Grau, Marta
name: Hardiman, Orla
name: Pender, Niall
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Mental Health

description: To examine the equivalency of ECAS versions A, B, and C in an Irish cohort, and to examine potential practice effects, 236 healthy controls were recruited through the Irish ALS control database. One hundred and seventy-six (176) controls completed ECAS version A, B, or C. Separately, 60 controls completed all three versions (A–B–C), consecutively, four months apart. TOST analysis found that ECAS A was equivalent to ECAS B and C. ECAS B and C were not statistically equivalent, however the difference between them was minimal. Participants showed improvement in ECAS performance over time, indicative of practice effects. Significant improvement was observed from time 1 to 2, but not from time 2 to 3. We propose Irish specific reliable change index (RCI) scores that take into consideration practice effects and measurement error. These thresholds will help quantify clinically meaningful cognitive decline in ALS patients, leading to improved quality of care.
Micropatterned Coculture of Stem Cell-derived Ventricular Cardiomyocytes and Adult Fibroblasts
Creators: name: Castella, Chiara
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Cardiovascular diseases are the leading causes of death in the world. Developing human and patient-specific in vitro models is fundamental for drug screening, disease modeling, and ultimately regenerative medicine. This thesis focuses on differentiating induced pluripotent stem cells (iPSC) into ventricular cardiomyocytes (iPSC-vCMs). However, current protocols yield cells that are not as mature as their adult cell counterparts. Therefore, this project leverages key biochemical cues, co-culture with non-parenchymal cells of the heart, and protein micropatterning to further mature iPSC-vCMs. Lastly, to enable more on-demand use of these cells for drug screening applications, this thesis optimizes a protocol to cryopreserve iPSC-vCMs and culture them using some of the techniques above. Ultimately, the maturation and cryopreservation approaches developed in this thesis can further enable the use of functionally matured iPSC-vCMs for the above applications.
title: Grundvorstellungen bei Zahlbereichserweiterungen
title: Basic ideas ('Grundvorstellungen') for numerical extensions
title: von N nach Q+ oder von N nach Z?
titleType: Subtitle
Creators: name: Fabian, Melina
Publisher: name: Universität Potsdam
Year: 2022
Subjects: subject: 510 Mathematik

description: Die Erweiterung des natürlichen Zahlbereichs um die positiven Bruchzahlen und die negativen ganzen Zahlen geht für Schülerinnen und Schüler mit großen gedanklichen Hürden und einem Umbruch bis dahin aufgebauter Grundvorstellungen einher. Diese Masterarbeit trägt wesentliche Veränderungen auf der Vorstellungs- und Darstellungsebene für beide Zahlbereiche zusammen und setzt sich mit den kognitiven Herausforderungen für Lernende auseinander. Auf der Grundlage einer Diskussion traditioneller sowie alternativer Lehrgänge der Zahlbereichserweiterung wird eine Unterrichtskonzeption für den Mathematikunterricht entwickelt, die eine parallele Einführung der Bruchzahlen und der negativen Zahlen vorschlägt. Die Empfehlungen der Unterrichtkonzeption erstrecken sich über den Zeitraum von der ersten bis zur siebten Klassenstufe, was der behutsamen Weiterentwicklung und Modifikation des Zahlbegriffs viel Zeit einräumt, und enthalten auch didaktische Überlegungen sowie konkrete Hinweise zu möglichen Aufgabenformaten.
description: The extension of the natural number range to include the positive fractions and the negative integers is accompanied by great mental hurdles for students and an upheaval of previously established basic concepts. This Master's thesis brings together essential changes at the level of imagination and representation for both number ranges and deals with the cognitive challenges for learners. Based on a discussion of traditional as well as alternative courses of number range extension, a teaching conception for mathematics lessons is developed that proposes a parallel introduction of fractions and negative numbers. The recommendations of the teaching conception cover the period from the first to the seventh grade, which allows a lot of time for the careful further development and modification of the number concept, and also contain didactic considerations as well as concrete hints on possible task formats.
Singlet vector leptoquark model facing recent LHCb and BABAR measurements
Creators: name: García-Duque, Cristian H.
name: Cabarcas, J. M.
name: Muñoz, J. H.
name: Quintero, Néstor
name: Rojas, Eduardo
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Very recently the LHCb experiment released the first measurement of the ratio $R(Λ_c) = {\rm BR}(Λ_b \to Λ_cτ\barν_τ)/{\rm BR}(Λ_b \to Λ_cμ\barν_μ)$. Moreover, the BABAR experiment reported a new result of the leptonic decay ratio of Upsilon meson $Υ(3S)$, namely, $R_{Υ(3S)} = {\rm BR}(Υ(3S) \to τ^+τ^-)/{\rm BR}(Υ(3S) \to μ^+μ^-)$. Both measurements are below their corresponding Standard Model predictions (deficit), deviating by $\sim 1.1σ$ and $\sim 1.8σ$, respectively. Moreover, the LHCb recently presented the first search of the lepton flavor violating decay $B^0 \to K^{\ast 0}μ^\pmτ^\mp$. Motivated by these new data, in this work we study their impact on the phenomenology of the singlet vector leptoquark ($U_1$) model addressing the hints of lepton flavor universality violation in the semileptonic decays of $B$ mesons ($B$ meson anomalies), by carrying out a global fit analysis. In general, we found that a minimal version of the $U_1$ model with a mass of 1.8 TeV can successfully explain the $B$ meson anomalies, while being compatible with all other flavor observables and LHC bounds. Interestingly, our study shows that the new observables $R(Λ_c)$ and $R_{Υ(3S)}$ generate strong tension, leading to non-trivial effects on the global fit. Future improvements at the LHCb and Belle II experiments would help to understand their complementarity. Moreover, we also analyze the impact of the expected sensitivity on flavor observables at Belle II to provide a further test of the $U_1$ model. Finally, we study the minimal assumptions under which the $U_1$ model could, in addition, provide a combined explanation of the anomalous magnetic moment of the muon.
description: 15 pages, 3 figures. V2: Typos fixed. New References added. Recent LHCb result on the LFV decay B^0 to K^{*0} mu^{+} tau^- (mu^{-} tau^+) included. Phenomenology analysis improved. Overall conclusions unchanged
Conditioned effects of heroin on proinflammatory mediators require the basolateral amygdala
Creators: name: Szczytkowski, Jennifer L.
name: Lysle, Donald T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Heroin administration alters the induction of nitric oxide, a molecule known to play a critical role in immune function. Previous research has shown that these alterations can be conditioned to environmental stimuli that have been associated with drug administration. Little is known about the brain areas that mediate these effects; however, the basolateral amygdala (BLA) has been implicated in the formation of stimulus-reward associations within models of drug abuse. The present study sought to determine whether inactivation of the BLA would alter heroin's conditioned effects on the expression of inducible nitric oxide synthase (iNOS) and the pro-inflammatory cytokines, TNF-α and IL-1β, in the rat. The conditioning procedure involved repeated pairing of heroin with placement into a standard conditioning chamber. To test the conditioned response, animals were returned to the previously drug-paired environment six days after the final conditioning session. Prior to testing, animals received intra-BLA microinfusions of a mixture of the GABA agonists, muscimol and baclofen. Following removal from the chambers on test day, all animals received subcutaneous lipopolysaccharide to induce systemic expression of iNOS, TNF-α and IL-1β. Analyses using real-time RT-PCR indicated that inactivation of the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS induction and on the expression of the pro-inflammatory cytokines TNF-α and IL-1β in spleen and liver tissue. This study is important because it is the first to demonstrate that heroin's conditioned effects on pro-inflammatory mediators require the basolateral amygdala. These findings may have significant implications for the treatment of heroin users.
Hawking radiation and interacting fields
Creators: name: Frasca, Marco
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Hawking radiation is generally derived using a non-interacting field theory. Some time ago, Leahy and Unruh showed that, in two dimensions with a Schwarzschild geometry, a scalar field theory with a quartic interaction gets the coupling switched off near the horizon of the black hole. This would imply that interaction has no effect on Hawking radiation and free theory for particles can be used. Recently, a set of exact classical solutions for the quartic scalar field theory has been obtained. These solutions display a massive dispersion relation even if the starting theory is massless. When one considers the corresponding quantum field theory, this mass gap becomes a tower of massive excitations and, at the leading order, the theory is trivial. We apply these results to Hawking radiation for a Kerr geometry and prove that the Leahy-Unruh effect is at work. Approaching the horizon the scalar field theory has the mass gap going to zero. We devise a technique to study the interacting scalar theory very near the horizon increasing the coupling. As these solutions are represented by a Fourier series of plane waves, Hawking radiation can be immediately obtained with well-known techniques. These results open a question about the behavior of the Standard Model of particles very near the horizon of a black hole where the interactions turn out to be switched off and the electroweak symmetry could be restored.
description: 12 pages, 1 figure. Fixed some LaTeX and added references. Accepted for publication in European Physical Journal Plus
Approximate Degradable Quantum Channels
Creators: name: Sutter, David
name: Scholz, Volkher B.
name: Winter, Andreas
name: Renner, Renato
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: 81P45

description: Degradable quantum channels are an important class of completely positive trace-preserving maps. Among other properties, they offer a single-letter formula for the quantum and the private classical capacity and are characterized by the fact that a complementary channel can be obtained from the channel by applying a degrading channel. In this work we introduce the concept of approximate degradable channels, which satisfy this condition up to some finite $\varepsilon\geq0$. That is, there exists a degrading channel which upon composition with the channel is $\varepsilon$-close in the diamond norm to the complementary channel. We show that for any fixed channel the smallest such $\varepsilon$ can be efficiently determined via a semidefinite program. Moreover, these approximate degradable channels also approximately inherit all other properties of degradable channels. As an application, we derive improved upper bounds to the quantum and private classical capacity for certain channels of interest in quantum communication.
description: v3: minor changes, published version. v2: 21 pages, 2 figures, improved bounds on the capacity for approximate degradable channels based on [arXiv:1507.07775], an author added
Supplementary data
Creators: name: Sheppard, Carmen L.
name: Manna, Sam
name: Groves, Natalie
name: Litt, David
name: Amin-Chowdhury, Zahin
name: bertran, marta
name: Ladhani, Shamez
name: Satzke, Catherine
name: Fry, Norman
Publisher: name: figshare
Year: 2022
Subjects: subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences

description: Supplementary data (Figures and Tables) for journal artilce entitled 'PneumoKITy: A fast, flexible, specific, and sensitive tool for Streptococcus pneumoniae serotype screening and mixed serotype detection from genome sequence data' submitted to Microbial Genomics by Carmen. L. Sheppard, Sam Manna, Natalie Groves, David J. Litt, Zahin Amin-Chowdhury, Marta Bertran, Shamez Ladhani, Catherine Satzke, Norman K. Fry.
Linear line spectropolarimetry as a new window to measure 2D and 3D wind geometries
Creators: name: Vink, Jorick S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Various theories have been proposed to predict how mass loss depends on the stellar rotation rate, both in terms of its strength, as well as its latitudinal dependence, crucial for our understanding of angular momentum evolution. Here we discuss the tool of linear spectropolarimetry that can probe the difference between mass loss from the pole versus the equator. Our results involve several groups of O stars and Wolf-Rayet stars, involving Oe stars, Of?p stars, Onfp stars, as well as the best candidate gamma-ray burst progenitors identified to date.
description: Conference talk, IAUS 307, "New windows on massive stars: asteroseismology, interferometry, and spectropolarimetry"
Nonequilibrium transport through quantum-wire junctions and boundary defects for free massless bosonic fields
Creators: name: Gawȩdzki, Krzysztof
name: Tauber, Clément
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a model of quantum-wire junctions where the latter are described by conformal-invariant boundary conditions of the simplest type in the multicomponent compactified massless scalar free field theory representing the bosonized Luttinger liquids in the bulk of wires. The boundary conditions result in the scattering of charges across the junction with nontrivial reflection and transmission amplitudes. The equilibrium state of such a system, corresponding to inverse temperature $β$ and electric potential $V$, is explicitly constructed both for finite and for semi-infinite wires. In the latter case, a stationary nonequilibrium state describing the wires kept at different temperatures and potentials may be also constructed. The main result of the present paper is the calculation of the full counting statistics (FCS) of the charge and energy transfers through the junction in a nonequilibrium situation. Explicit expressions are worked out for the generating function of FCS and its large-deviations asymptotics. For the purely transmitting case they coincide with those obtained in the litterature, but numerous cases of junctions with transmission and reflection are also covered. The large deviations rate function of FCS for charge and energy transfers is shown to satisfy the fluctuation relations and the expressions for FCS obtained here are compared with the Levitov-Lesovic formulae.
description: 50 pages, 24 figures
Passenger Train Delay Prediction using Machine Learning
Creators: name: Lapamonpinyo, Pipatphon
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Passenger train delay (PTD) is a challenging problem in rail transport. PTD means more uncertainty and unreliability for rail operators and higher dissatisfaction for passengers. Accurately predicting PTD can help rail operators adjust their operation and reduce passenger dissatisfaction. Leveraging advances in Machine Learning, this dissertation focuses on modelling Passenger Train Delay Prediction (PTDP) for Amtrak, the primary rail operator in the United States. Specifically, this dissertation offers three main contributions: (1) a Python-based Amtrak and Weather Underground (PAWU) data retrieving tool, 2) a station-to-station PTDP model, and 3) a universal PTDP model. In the first contribution, the PAWU tool is developed to retrieve historical train data from Amtrak and weather information from Weather Underground (used later to model PTDP). In the second contribution, Random Forest (RF), Gradient Boosting Machine (GBM), and Multi-Layer Perceptron (MLP) are utilized to build station-to-station PTDP models for individual station-to-station trip combinations. Two different data-frame structures are proposed, one using only real-time data and another using both real-time and historical data. The results show that using MLP with real-time and historical data works best. In the third contribution, a universal PTDP model is developed that can be used to predict PTD between any pair of stations by using RF and MLP. Unlike station-to-station model, here, the results show that RF performs best. In addition, the influence on PTD of several exogenous variables such as ridership, population, infrastructure and geography, historical delay profile at destination (HDPD), calendar, and weather information are also examined and discussed.
title: Circulation of large water bodies caused by aerator
Creators: name: Siew Tong, Ling
Publisher: name: University of Liverpool Repository
Year: 2023

description: Aerators had always been widely used for vanous purposes. The scale of the applications ranged from household fish tanks to water treatment plants. It was also applied to re-circulate large water body reservoirs, which this thesis aimed to address. Despite the wide application, the hydrodynamic theories of the flows created as a result of .air bubble plume application were still not totally validated. Therefore experimental results from past researches and from the present studies were used to validate the mathematical model of Goossens et ai's [1979,1980,1982], Fannelop et ai's [1980, 1991], in which the accuracy of the models were found to be less accurate than claimed in the publications. Through the experiments conducted, valuable results were obtained. These results were not only applied for numerical model validations mentioned above, but also used to clarify the physical characteristic of the circulations. Through these experiments, it was found that the secondary circulation do contribute to the overall mixing process, but in a slower process. The dye injected to trace the physical circulations was detected using the dye concentration detector known as SCUFA, in which the data were utilized to determine the concentration dispersion coefficient caused by the aeration. A commercial CFD software known as FLUENT was applied to model the case of aeration in both the homogenous and stratified conditions. Investigations were carried out systematically to determine suitable settings for the simulation. Experimental results obtained from the present study and from other published researches were used to verify and validate the CFD model. The results from the CFD model were compared with the experimental results through the vertical velocity profile, horizontal velocity profile and the overall circulation pattern. A verified and validated CFD model of the bubble aeration in the homogenous was obtained, in which the vertical velocity profile within the bubble plume, the horizontal outflow velocity profile and the overall circulation pattern can be accurately simulated. However, the simulation of the stratified conditions reqUIres a more complex procedure, in which the surface boundary condition has resulted in various inaccurate simulations. A 'Used Defined Function' was subsequently created to deal with the problem. A working FLUENT model for the stratified condition was successfully created in the end and the simulated results were validated with experimental results.
Distinct subsets of nucleus accumbens neurons encode operant responding for ethanol versus water
Creators: name: Carelli, Regina M.
name: Robinson, Donita L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Subsets of nucleus accumbens neurons process information about operant responses for drug as well as natural rewards (food and water) by excitations and inhibitions in firing rate time-locked to the operant response. The degree to which ensembles of neurons exhibit similar firing patterns when encoding cues and operant responses across different reinforcer conditions will provide critical information regarding the functional organization of this nucleus. The present experiment evaluated the relative contribution of subsets of accumbens neurons that encode distinct features of lever press responding for ethanol versus water. Electrophysiological recordings (n = 153 neurons) were made in the accumbens of rats trained on concurrent reinforcement schedules for ethanol and water throughout a self-administration session. During operant responding, 52% of neurons exhibited patterned discharges characterized by significant increases or decreases in firing rate ±1 s relative to lever presses for ethanol and/or water. Of these phasic cells, 85% discriminated between presses for ethanol and water (i.e., exhibited firing patterns unique to one reinforcer type), while 15% exhibited identical firing patterns relative to lever presses for both reinforcers. Notably, the data revealed that both high ethanol preference and spatially distinct lever positions contributed to the reinforcer specificity. Together, these data demonstrate that subsets of nucleus accumbens neurons encode conditioned and instrumental aspects of ethanol versus water reinforcement in well-trained rats, and that reinforcer preference and spatial cues are important components of this differential information processing.
Elliptic Hamilton-Jacobi systems and Lane-Emden Hardy-H{é}non equations
Creators: name: Bidaut-Véron, Marie-Françoise
name: Huidobro, Marta Garcia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: Here we study the solutions of any sign of the system --$Δ$u 1 = |$\nabla$u 2 | p , --$Δ$u 2 = |$\nabla$u 1 | q , in a domain of R N , N 3 and p, q > 0, pq > 1.. We show their relation with Lane-Emden Hardy-H{é}non equations --$Δ$ N p w= $ε$r $σ$ w q , $ε$ = $\pm$1, where u $\rightarrow$ $Δ$ N p u (p > 1) is the p-Laplacian in dimension N, q > p -- 1 and $σ$ $\in$ R. This leads us to explore these equations in not often tackled ranges of the parameters N, p, $σ$. We make a complete description of the radial solutions of the system and of the Hardy-Henon equations and give nonradial a priori estimates and Liouville type results.
Open-source methods for DNA manipulation in a cloud lab
Creators: name: Vali, Shaik Waseem
name: Crone, Michael
name: Cortade, Dana
name: Kohler, Amanda
name: DeBenedictis, Erika
name: Brunette, TJ
Publisher: name: Zenodo
Year: 2024

description: Automating biological research has the potential to improve reproducibility, throughput, and free-up scientist time to design rather than execute experiments. One avenue for scientists to leverage automation is through the use of cloud labs. However, there is no publicly available open source code to conduct basic life science workflows in cloud labs, and resources to learn the code are very limited, creating an enormous barrier to entry to cloud science. Here we present the first ever set of validated, open source protocols for cloud labs. We have developed a full pipeline for manipulating DNA on Emerald Cloud Lab’s platform, including onboarding samples, conducting PCR and Golden Gate reactions, and assessing the quality of samples with purification and gel electrophoresis. Each script is open source and available on GitHub, and we also provide instructions and screencast videos for future users. This work represents a necessary first step toward enabling cloud labs to mature into a widely accessible tool for life sciences
Basolateral amygdala involvement in memory reconsolidation processes that facilitate drug context-induced cocaine seeking
Creators: name: Bell, Guinevere H.
name: Su, Zu-In
name: Ramirez, Donna R.
name: Eaddy, Jessica L.
name: Fuchs, Rita A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Understanding the neurobiological underpinnings of putative memory stabilization processes that maintain context-response-cocaine associations in long-term memory and underlie contextual control over addictive behavior is of great interest from an addiction treatment perspective. Using an instrumental animal model of contextual drug relapse, we show that the protein synthesis inhibitor, anisomycin, administered into the basolateral amygdala (BLA) immediately after limited (15- or 60-min) re-exposure to a previously cocaine-paired context subsequently disrupted the ability of the previously cocaine-paired context to reinstate extinguished cocaine-seeking behavior relative to vehicle. Consistent with a BLA-mediated memory reconsolidation deficit, similar impairment in cocaine-seeking behavior was not observed in “no-reactivation” control groups that received anisomycin into the BLA after (re)exposure to either a novel unpaired or an extinction-paired context nor in a neuroanatomical control group that received anisomycin into the posterior caudate-putamen, dorsally adjacent to the BLA, after re-exposure to the cocaine-paired context. Furthermore, anisomycin administered into the BLA after brief (5-min) or extensive (120-min) re-exposure to the cocaine-paired context (which was sufficient to extinguish cocaine-seeking behavior in a vehicle control group) also failed to alter responding. Together, these findings suggest that re-exposure to a cocaine-paired context in the absence of cocaine reinforcement is sufficient to trigger memory reconsolidation processes that support future drug-seeking behavior. The presence and duration of drug-related memory reactivation critically influences and anisomycin-sensitive mechanisms in the BLA selectively control this phenomenon. These findings support the feasibility of novel pharmacotherapeutic approaches that selectively inhibit the reconsolidation of cocaine-related memories in order to prevent drug relapse.
of In Silico Modeling of Indigo and Tyrian Purple Single-Electron Nano-Transistors Using Density Functional Theory Approach
Creators: name: Shityakov, Sergey
name: Roewer, Norbert
name: FĂśrster, Carola
name: Jens-Albert Broscheit
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: of In Silico Modeling of Indigo and Tyrian Purple Single-Electron Nano-Transistors Using Density Functional Theory Approach
Design, In silico Studies and Biological Evaluation of New Chiral Thiourea and 1,3-Thiazolidine-4,5-dione Derivatives
Creators: name: evyapan, samet
name: oruç-emre, emine elçin
name: Sıcak, Yusuf
name: Karaküçük-Iyidoğan, Ayşegül
name: Yılmaz, Gizem Tatar
name: Öztürk, Mehmet
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 340401
subject: Biologically active molecules
classificationCode: 340503
subject: Organic chemical synthesis

description: In this study, new chiral thiourea and 1,3-thiazolidine-4,5-dione derivatives were synthesized, it was aimed to evaluate the various biological activities and molecular docking of these compounds. Firstly, the new thioureas (1-16) were obtained by reacting 1-naphthylisothiocyanate with different chiral amines. Then, the chiral thioureas were cyclized with oxalyl chloride to obtain 1,3-thiazolidine-4,5-dione derivatives (17-32). All compounds were evaluated with several in vitro antioxidant and enzyme inhibition activities. Compound 30 was the most active compound against AChE, with a value of IC50=8.09±0.58 µM. On the other hand, all compounds were tested in silico absorption, distribution, metabolism, and excretion (ADME) assays to better understand their bioavailability. These physicochemical properties, pharmacokinetics, and drug-likeness of all compounds were calculated using SwissADME. Furthermore, according to molecular docking analyses compound 30 exhibited significant binding affinities for all enzymes. Based on our overall observations, compound 30 could be recommended as a potential lead for the therapeutics of Alzheimer's
title: Transatlanticism and Translation
Creators: name: Richter, Sandra
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 800 Literature (Belles-lettres) and rhetoric
subject: 809 History, description, critical appraisal of more than two literatures
subject: 890 Literatures of other specific languages and language families

description: Gayatri Chakravorty Spivak erkannte 2003 in ihrem Essay "Death of a Discipline", dass der Eurozentrismus ein grundlegendes und wesentliches Merkmal der Komparatistik sei. Der Begriff 'Transatlanticism' wirkt entsprechend altmodisch. Um der abnehmenden Relevanz übersetzter Literatur in den USA und der zunehmenden globalen Dominanz englischsprachiger Literatur (in Übersetzung) entgegenzuwirken, ist er jedoch nützlich. Die transatlantische Übersetzungsgeschichte zwischen Deutschland und den USA hilft, die begünstigenden Faktoren für die gegenseitige Rezeption zu ermitteln: Verlagshäuser, die sich der gemeinsamen literarischen Geschichte verschreiben, das Engagement exilierter Verleger und herausragender Einzelpersönlichkeiten, persönliche Aquisitionsreisen und zielgruppengerechte Übersetzungen. Eine Perspektive bietet die internationale Debatte um Amanda Gorman: Ästhetische und politische Forderungen an ihre Übersetzungen wurden in der breiten Öffentlichkeit diskutiert.
description: In her essay "Death of a Discipline" (2003) Gayatri Chakravorty Spivak recognized that Eurocentrism was a fundamental and essential feature of comparative studies. The term 'transatlanticism', thus, seems outdated. However, it is useful in countering the declining relevance of translated literature in the US and the increasing global dominance of English-language literature (in translation). The transatlantic translation history between Germany and the US helps to identify the factors favoring mutual reception: Publishing houses committing to a shared literary history, the engagement of exiled publishers and outstanding individuals, personal acquisition travels, and providing translations adequate for their target groups. The international debate about Amanda Gorman offers a promising perspective: aesthetic and political demands on her translations were discussed by the general public.
Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats
Creators: name: Xie, Xiaou
name: Traina, Stephanie A.
name: Fuchs, Rita A.
name: Bell, Guinevere H.
name: Ramirez, Donna R.
name: Lasseter, Heather C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Exposure to a cocaine-paired context increases the propensity for relapse in cocaine users and prompts cocaine-seeking behavior in rats. According to the reconsolidation hypothesis, upon context re-exposure, established cocaine-related associations are retrieved and can become labile. These associations must undergo reconsolidation into long-term memory to effect enduring stimulus control. The dorsal hippocampus (DH), dorsolateral caudate-putamen, and dorsomedial prefrontal cortex are critical for the expression of context-induced cocaine seeking, and these brain regions may also play a role in the reconsolidation of cocaine-related memories that promote this behavior. To test this hypothesis, rats were trained to press a lever for un-signaled cocaine infusions (0.2 mg/infusion, IV) in a distinct environmental context (cocaine-paired context), followed by extinction training in a different context (extinction context). Rats were then re-exposed to the cocaine-paired context for 15 min in order to reactivate cocaine-related memories or received comparable exposure to a novel unpaired context. Immediately thereafter, rats received bilateral microinfusions of the protein synthesis inhibitor anisomycin, the sodium channel blocker tetrodotoxin, or vehicle into one of the above brain regions. After additional extinction training in the extinction context, reinstatement of cocaine-seeking behavior (i.e., non-reinforced lever presses) was assessed in the cocaine-paired context. Tetrodotoxin, but not anisomycin, administered into the DH inhibited drug context-induced cocaine-seeking behavior in a memory reactivation-dependent manner. Other manipulations failed to alter this behavior. These findings suggest that the DH facilitates the reconsolidation of associative memories that maintain context-induced cocaine-seeking behavior, but it is not the site of anisomycin-sensitive memory re-stabilization per se.
An Evaluation of Multimedia Content in a Critical Care Pharmacotherapeutic Course
Creators: name: Benken, Scott Thomas
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Our objective was to investigate the alignment between didactic multimedia materials utilized by pharmacy faculty with Mayer's Principles for Multimedia Learning and faculty characteristics associated with greater alignment. We used a systematic process including a modified version of the Learning Object Review Instrument (LORI) to evaluate faculty video-recorded lectures for alignment with Mayer’s Principles of Multimedia Learning capturing the number and type of misalignments. We used correlations to evaluate the association between faculty characteristics and ratings and proportions of misalignments. Five-hundred-fifty-five PowerPoint slides were reviewed from 13 lectures from 13 faculty members. The average (SD) LORI score per slide was 4.44 (0.84) out of 5 with an average score per lecture from 3.83 (0.96) to 4.95 (0.53). Across all lecture slides, misalignments with multimedia principles were captured in 20.2% of slides. For each lecture, the average percentage of misalignments was 27.6% ranging from 0% to 49%. The principal misalignments included Coherence, 66.1%; Signaling, 15.2%; and Segmenting, 8% violations. No faculty characteristics were significantly associated with LORI ratings or proportion of misalignments within lectures. Faculty had high LORI ratings for their multimedia material. Nonetheless, misalignments with multimedia principles were identified and related primarily to extraneous processing. These misalignments, when addressed, have the potential to improve learning, suggesting an opportunity for faculty development to optimize multimedia educational delivery. Future investigation is needed to clarify how clinical pharmacy faculty develop multimedia material and the impact of faculty development on the application of multimedia principles and on learning outcomes.
In vivo voltammetric monitoring of norepinephrine release in the rat ventral bed nucleus of the stria terminalis and anteroventral thalamic nucleus
Creators: name: Kile, Brian M.
name: Mark Wightman, R.
name: Park, Jinwoo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The role and contribution of the dense noradrenergic innervation in the ventral bed nucleus of the stria terminalis (vBNST) and anteroventral thalamic nucleus (AV) to biological function and animal behaviors is poorly understood due to the small size of these nuclei. The aim of this study was to compare norepinephrine release and uptake in the vBNST with that in the AV of anesthetized rats. Measurements were made in vivo with fast-scan cyclic voltammetry following electrical stimulation of noradrenergic projection pathways, either the dorsal noradrenergic bundle (DNB) or the ventral noradrenergic bundle (VNB). The substance detected was identified as norepinephrine based upon voltammetric, anatomical, neurochemical, and pharmacological evidence. Fast-scan cyclic voltammetry enables the selective monitoring of local norepinephrine overflow in the vBNST evoked by the stimulation of either the DNB or VNB while norepinephrine in the AV was only evoked by DNB stimulation. The α2-adrenoceptor antagonist, yohimbine, and the norepinephrine uptake inhibitor, desipramine, increased norepinephrine overflow and slowed its disappearance in both regions. However, control of extracellular norepinephrine by both autoreceptors and uptake was greater in the AV. The greater control exerted by autoreceptors and uptake in the AV resulted in reduced extracellular concentration compared to the vBNST when large numbers of stimulation pulses were employed. The differences in noradrenergic transmission observed in the terminal fields of the vBNST and the AV may differentially regulate activity in these two regions that both contain high densities of norepinephrine terminals.
Sampling Constrained Continuous Probability Distributions: A Review
Creators: name: Lan, Shiwei
name: Kang, Lulu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation (stat.CO)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: The problem of sampling constrained continuous distributions has frequently appeared in many machine/statistical learning models. Many Monte Carlo Markov Chain (MCMC) sampling methods have been adapted to handle different types of constraints on the random variables. Among these methods, Hamilton Monte Carlo (HMC) and the related approaches have shown significant advantages in terms of computational efficiency compared to other counterparts. In this article, we first review HMC and some extended sampling methods, and then we concretely explain three constrained HMC-based sampling methods, reflection, reformulation, and spherical HMC. For illustration, we apply these methods to solve three well-known constrained sampling problems, truncated multivariate normal distributions, Bayesian regularized regression, and nonparametric density estimation. In this review, we also connect constrained sampling with another similar problem in the statistical design of experiments of constrained design space.
Large deviations for Generalized Polya Urns with arbitrary urn function
Creators: name: Franchini, Simone
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60J10, 60J80

description: We consider a generalized two-color Polya urn (black and withe balls) first introduced by Hill, Lane, Sudderth where the urn composition evolves as follows: let $π:\left[0,1\right]\rightarrow\left[0,1\right]$, and denote by $x_{n}$ the fraction of black balls after step $n$, then at step $n+1$ a black ball is added with probability $π\left(x_{n}\right)$ and a white ball is added with probability $1-π\left(x_{n}\right)$. Originally introduced to mimic attachment under imperfect information, this model has found applications in many fields, ranging from Market Share modeling to polymer physics and biology. In this work we discuss large deviations for a wide class of continuous urn functions $π$. In particular, we prove that this process satisfies a Sample-Path Large Deviations principle, also providing a variational representation for the rate function. Then, we derive a variational representation for the limit $ϕ\left(s\right)=\lim_{n\rightarrow\infty}{\textstyle \frac{1}{n}}\log\mathbb{P}\left(\left\{ nx_{n}=\left\lfloor sn\right\rfloor \right\} \right),\, s\in\left[0,1\right]$, where $nx_{n}$ is the number of black balls at time $n$, and use it to give some insight on the shape of $ϕ\left(s\right)$. Under suitable assumptions on $π$ we are able to identify the optimal trajectory. We also find a non-linear Cauchy problem for the Cumulant Generating Function and provide an explicit analysis for some selected examples. In particular we discuss the linear case, which embeds the Bagchi-Pal Model, giving the exact implicit expression for $ϕ$ in terms of the Cumulant Generating Function.
description: 38 pages, 7 figures