cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biosimilars 2024
Creators: name: MANDHARE, AMOL
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310602
subject: Bioprocessing, bioproduction and bioproducts
classificationCode: 310606
subject: Industrial molecular engineering of nucleic acids and proteins
classificationCode: 321405
subject: Pharmaceutical sciences
classificationCode: 321404
subject: Pharmaceutical delivery technologies
classificationCode: 320603
subject: Medical molecular engineering of nucleic acids and proteins

description: Biosimilars, a rapidly growing category of medications in The United States of America (US), play a vital role in addressing health conditions. This study provides a comprehensive overview of the distinctions between Biosimilars and Generics, examining the Biosimilar landscape with a focus on approved products and those in the pipeline from key market players. Emphasizing the cost-effectiveness of Biosimilars akin to Generics, the paper outlines the intricate differences between them, highlighting the divergence in The United States Food and Drug Administration (US FDA) approval pathways for Biosimilars and Generics. The paper further explores regulatory frameworks, including the Biologics Price Competition and Innovation Act (BPCIA), offering insights into approved Biosimilar products. Recognizing the challenges in Biosimilar development and evaluating the pros and cons in comparison to Generics are crucial for healthcare professionals and patients navigating this dynamic landscape. As the pharmaceutical industry progresses, this paper aims to elucidate current approaches and key considerations in the field of Biosimilars.
Towards a Neo-Blochian Theory of Complexity, Hope and Cinematic Utopia
Creators: name: Hammond, Craig
Publisher: name: figshare
Year: 2014
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: The thesis sketches-out three main and general philosophical, analytical and utopian-strategic areas: Initially, the project begins with a cumulative overview (i.e. drawing upon a collection of authors and publications) of the Marxist philosopher of hope and utopia Ernst Bloch, and, the Blochian philosophical framework. I focus upon, and, analyse several specific philosophical areas within the Blochian framework, notably, those of the chaos of the trace, and Bloch’s unifying (unfolding, trans-historical) category of Hope and Utopia. In order to navigate this difficult philosophical terrain, the thesis proposes several conceptual and neologistic “inventions” – associated with chaos and complexity – so as to invoke a potentially useful (neo)-Blochian philosophical vocabulary. The project then applies Bloch and the Blochian utopian framework to the specific area of popular film/cinema (and, within this, the portrayal of “beautiful monsters”). The neo-Blochian concepts are then applied to utopian cinematic metaphors, images and themes concerning “beautiful monsters”; in exploration of this, I embark upon several contra-punctive Blochian (and, neo-Blochian) analyses of a selection of popular films
Qualitative and structural analysis of the managerial competency of future physical education and sport specialists
Creators: name: Dubrevskiy, Yuriy
Publisher: name: figshare
Year: 2014
Subjects: Education

description: Purpose: identifying theoretical and practical communication management competence in vocational training of future specialists of physical education and sport. Material: analysis of 220 literary sources of psycho-pedagogical nature, sports theory, control theory, methods of physical education, which cover the administrative aspect of modern specialist training. Results: the need to form a managerial competency in the process of future specialists in education and sport preparation with regard to its qualitative and structural characteristics was established in the research. Conclusions: there is an evidence that the meaningful impact on the development of managerial competency takes place successfully under conditions of personal socialization in the communicative environment; orientation towards systematic assimilation of knowledge about the phenomenon of management, focus on the effective implementation of activities; development of professional and individual characteristics, which together meet the objectives and content of the pedagogical preparation of students.
PHYSICAL EDUCATION AND SPORTS IN STUDENTS' LIFE
Creators: name: Allaev, Sherkul
Publisher: name: Zenodo
Year: 2024

description: This article examines the role and importance of physical education and sports in university students' lives, analyzing their impact on academic performance, physical health, mental well-being, and social development. Through a comprehensive literature review, the study explores various aspects of student engagement in sports activities and their long-term benefits.
Suspended particulate matter as an indicator for turbulent diffusion due to ocean surface waves
Creators: name: Pleskachevsky, A.
name: Dobrynin, M.
name: Babanin, Alexander
Publisher: name: Swinburne
Year: 2024

description: Sometimes modelled Suspended Particulate Matter (SPM) shows large deviations from measurement. These problems may be related to insufficient model physics or incorrect parameterizations. On the other side, the large sensitivity of SPM to external forcing and internal processes makes it a perfect marker to study turbulence in the ocean, because the vertical distribution of SPM depends on settling velocities and turbulence, which propagate material from bottom up to the surface in shallow seas. Satellite observations in the North Sea show that the SPM concentration at the surface grows rapidly during a storm and builds plume-shaped structures. The satellite data reveal also that SPM concentration decreases rapidly after the wave height decreases, justifying the hypothesis that strong turbulence created by surface waves is a major contributor to the SPM dynamics. In this paper, the impact of the surface waves on the turbulent mixing in the North Sea is studied. The wave-induced turbulence is parameterized and implemented into the General Ocean Turbulence Model (GOTM) as an additional source of turbulent kinetic energy (TKE). A number of tests experiments are carried out in order to reproduce experiments in a water tank and observations in the North Sea. In a tank ink is injected into water of 1 m depth. Experiments with 0,667 Hz frequency waves of different amplitudes (no winds, no currents) are done. If the amplitude is less than 2 cm, the ink is moving along the wave orbits. The patch stays unchanged for minutes. The motion is clearly laminar. For amplitudes of about 3 cm some vortexes become visible eroding the upper parts of ink pattern. For amplitudes greater than 4 cm the motion is obviously turbulent and the ink is completely dissolved within seconds. The extended GOTM model reproduces these observations. In the North Sea the data from the satellites MOS (Modular Optoelectronic Scanner) and MERIS (MEdiumspectral Resolution Imaging Spectrometer) are used to derive the SPM concentration at the surface. The circulation model HAMSON and the wave model WAM are applied to reconstruct the hydrodynamics and sea state. Erosion and sedimentation processes taken from the Suspended Particulate Mater Transport model (SPMT), developed in the GKSS Research Center and German Federal Maritime and Hydrographic Agency (BSH), are combined with the extended GOTM model. Results will be shown demonstrating the importance of waves for the vertical mixing processes in the Southern North Sea during storm situations. This mixing is most significant in the upper layers and strongly influences the SPM patterns.
title: Keine Diktatur der Volksherrschaft!: Warum Volksrechte und Menschenrechte nicht gegeneinander ausgespielt werden sollten
Creators: name: Kunz, Raffaela
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2014
Subjects: subject: 341

description: Völkerrechtsblog
title: „Dass der EuGH als internationales Gericht angesehen wird, ist ein großes Missverständnis“: Interview mit Prof. Dr. Koen Lenaerts, Vize-Präsident des Europäischen Gerichtshofs
Creators: name: Lenaerts, Koenraad
name: Birkenkötter, Hannah
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2014
Subjects: subject: 341

description: Völkerrechtsblog
Publier en Open Access sans frais grâce aux accords de l'UNIGE, en 15 minutes
Creators: name: Muller, Floriane
name: Santos, Anouk
Publisher: name: Université de Genève
Year: 2025
Subjects: Open Access
frais de publication (APC)
accords Read&Publish
publication scientifique
Open Science

description: Présentation utilisée lors des rendez-vous de l'information scientifique en 15 minutes organisés par la Bibliothèque de l'Université de Genève et consacrés aux accords Read&Publish avec les maisons d'éditions de publications scientifiques. La présentation a été donnée pour la première fois dans le cadre de l'Open Access Week 2022, et a été proposée plusieurs fois depuis, avec de petites mises à jour sur les diapositives en fonction notamment de l'évolution des accords signés par la Bibliothèque de l'UNIGE.

Objectif : Découvrir les accords permettant aux auteur-es UNIGE de publier leurs recherches en Open Access sans frais ou à moindre coût, ainsi que leurs conditions d'application.

Programme/Contenus :

Présenter l'évolution de la publication scientifique avec l'émergence de nouveaux types d'accords avec les éditeurs

Identifier les enjeux des négociations nationales

Localiser les informations sur les accords et les conditions applicables pour la prise en charge (complète ou partielle) des frais.
Spin temperatures and covering factors for H I 21-cm absorption in damped Lyman a systems
Creators: name: Curran, S. J.
name: Murphy, Michael
name: Pihlström, Y. M.
name: Webb, J. K.
name: Purcell, C. R.
Publisher: name: Swinburne
Year: 2024

description: We investigate the practice of assigning high spin temperatures to damped Lyman α absorption systems (DLAs) not detected in H i 21-cm absorption. In particular, Kanekar & Chengalur have attributed the mix of 21-cm detections and non-detections in low-redshift (zabs≤ 2.04) DLAs to a mix of spin temperatures, while the non-detections at high redshift were attributed to high spin temperatures. Below zabs= 0.9 , where some of the DLA host galaxy morphologies are known, we find that 21-cm absorption is normally detected towards large radio sources when the absorber is known to be associated with a large intermediate (spiral) galaxy. Furthermore, at these redshifts, only one of the six 21-cm non-detections has an optical identification and these DLAs tend to lie along the sight-lines to the largest background radio continuum sources. For these and many of the high-redshift DLAs occulting large radio continua, we therefore expect covering factors of less than the assumed/estimated value of unity. This would have the effect of introducing a range of spin temperatures considerably narrower than the current range of ΔTs≳ 9000 K , while still supporting the hypothesis that the high-redshift DLA sample comprises a larger proportion of compact galaxies than the low-redshift sample.
Exploring variations in the fundamental constants with ELTs: The CODEX spectrograph on OWL
Creators: name: Molaro, Paolo
name: Murphy, Michael
name: Levshakov, Sergei A.
Publisher: name: Swinburne
Year: 2024

description: Cosmological variations in the fine structure constant, α, can be probed through precise velocity measurements of metallic absorption lines from intervening gas clouds seen in spectra of distant quasars. Data from the Keck/HIRES instrument support a variation in α of 6 parts per million. Such a variation would have profound implications, possibly providing a window into the extra spatial dimensions required by unified theories such as string/M-theory. However, recent results from VLT/UVES suggest no variation in α. The COsmic Dynamics EXperiment (CODEX) spectrograph currently being designed for the ESO OWL telescope (Pasquini et al. 2005) with a resolution high enough to properly resolve even the narrowest of metallic absorption lines, R > 150 000, will achieve a 2-to-3 order-of-magnitude precision increase in Δα/α. This will rival the precision available from the Oklo natural fission reactor and upcoming satellite-borne atomic clock experiments. Given the vital constraints on fundamental physics possible, the ELT community must consider such a high-resolution optical spectrograph like CODEX.
Acoustic Monitoring of Blast Fishing: Pilot Study
Creators: name: Cagua, Edgar Fernando
name: Basset, Christopher
name: Kayanda, Robert
name: Rubens, Jason
Publisher: name: figshare
Year: 2014
Subjects: Marine Biology

description: Technical report: WWF Tanzania Country Office - Marine Programme Blast fishing is illegal fishing method according to Fisheries Act (2003) due to its negative impact especially on coral reefs. The method is widely used and it is a serious problem along the coast of Tanzania mainland. The most affected area is Dar es Salaam, where existing regulations are not effectively enforced to address the problem. Inadequate data on the frequency of occurrence and distribution of blast activity prevent effective control measures. Using Digital Spectrogram Long-Term Acoustic Recorders (DSG), we performed two deployments. One was a two-day long deployment to identify the acoustic characteristics of blasts, and the second was a two- month long deployment to monitor blast activity off Dar es Salaam coast. In the blast identification phase we deployed one DSG over two days on Milliards Bank recording sound at 80 kHz, we analysed the acoustic characteristics of 45 underwater explosions to identify and characterize blasts used during illegal fishing operations. We developed a neural- network that semi-automatically identifies explosion-like recordings. Ninety-five percent of the explosion-like events identified by the neural network are attributable to blast fishing, while the other five percent were other unidentified transient signals. During the monitoring phase two DSGs were deployed, however we were able to retrieve only one of them. Weather, currents, and possibly vandalism might be the causes for the loss. The retrieved DSG was deployed on Mbudya patches between 15 April and 30 May, 2014 recording at a sampling frequency of 40kHz during five minutes every ten minutes between 0600 and 1800 hrs. Using this additional data the neural network improved its classification accuracy to 98%. We estimate an average of 19 blasts per day during daytime off Mbudya, with most of the blasts occurring in the morning before 1300 hrs. To avoid further loss of instruments, we recommend the use of acoustic releases in further deployments. However care must be taken to avoid potential problems caused by biofouling as well as preventing interference from noise near the DSGs caused by floats and moving elements part of the release. In order to better understand blast fishing patterns as well as factors influencing underwater noise production we also recommend recording environmental variables related to weather and currents. This work represents the first steps of a potential future monitoring program off the Tanzanian coast. We provide methods and recommendations for future monitoring of blast fishing
Open Access publishing at no cost thanks to UNIGE agreements, in 15 minutes
Creators: name: Muller, Floriane
name: Santos, Anouk
Publisher: name: Université de Genève
Year: 2024
Subjects: Open Access
publication costs (APC)
Read&Publish agreements
scientific publishing
Open Science

description: This is the slide deck of the rendez-vous de l'information scientifique organised by the University of Geneva Library and devoted to the University's Read & Publish agreements with scientific publishers. The presentation was first given as part of Open Access Week 2022, and has been offered a few times since, with small updates on the slides.

Objective: To discover the agreements allowing UNIGE authors to publish their research in Open Access at no or low cost, as well as their terms & conditions.

Program/Contents:

Present the evolution of scientific publishing with the emergence of new types of agreements with publishers

Identify the issues at stake in national negotiations

Locate information on the agreements and the conditions applicable for the (full or partial) coverage of costs.
description: A french version of this presentation is available at: https://doi.org/10.5281/zenodo.7846610.
title: Symposium: Verfassungs- und Völkerrecht im Spannungsverhältnis: Von Global Cities und gallischen Dörfern
Creators: name: Schmalz, Dana
name: Birkenkötter, Hannah
name: Kunz, Raffaela
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2014
Subjects: subject: 341

description: Völkerrechtsblog
SABZAVOT VA SARAXA, O'SIMLIGINI YETISHTIRISH TARTIBI VA DORIVORLIK XUSUSIYATI
Creators: name: Jahbaraliyev, Qudratillo
name: Saksonboyeva, Mushtariy
name: To'xtasinova, Rayxongul
Publisher: name: Zenodo
Year: 2024

description: Maqolada mayoran oʻsimligining kelib chiqishi, yashash sharoyiti, koʻpayish usullari, marfalogiyasi hamda anatomiyasi va shuni ham taʼkidlab oʻtishimiz kerakki dorivor oʻsimlik boʻlganligi sababli jahon miqyosida juda katta eʼtiborga ega oʻsimliklar ekanligi toʻgʻrisida fikr yuritiladi.
Dust-reddening and gravitational lensing of SDSS QSOs due to foreground damped Lyman α systems
Creators: name: Murphy, Michael
name: Liske, J.
Publisher: name: Swinburne
Year: 2024

description: We use Sloan Digital Sky Survey (SDSS) Data Release 2 quasi-stellar object (QSO) spectra to constrain the dust-reddening caused by intervening damped Lyman alpha systems (DLAs). Comparing the spectral index distribution of a 70 sight-line DLA sample with that of a large control sample reveals no evidence for dust-reddening at zsimilar to3. Our limit on the shift in spectral index, Deltaalpha<0.19 (3σ), corresponds to a limit on the colour excess due to Small Magellanic Cloud-like dust-reddening, E(B-V)<0.02 mag (3). This is inconsistent with the early studies of Fall, Pei and collaborators who used the small QSO and DLA samples available at the time. Comparison of the DLA and control magnitude distributions also reveals greater than or similar to 2sigma evidence for an excess of bright and/or a deficit of faint QSOs with foreground DLAs. Higher equivalent width DLAs give a stronger signal. We interpret this as the signature of gravitational magnification due to the intervening DLAs.
Publier en Open Access sans frais grâce aux accords de l'UNIGE, en 15 minutes
Creators: name: Muller, Floriane
name: Santos, Anouk
Publisher: name: Zenodo
Year: 2023
Subjects: Open Access
frais de publication (APC)
accords Read&Publish
publication scientifique
open science

description: Présentation utilisée lors des rendez-vous de l'information scientifique en 15 minutes organisés par la Bibliothèque de l'Université de Genève et consacrés aux accords Read&Publish avec les maisons d'éditions de publications scientifiques. La présentation a été donnée pour la première fois dans le cadre de l'Open Access Week 2022, et a été proposée plusieurs fois depuis, avec de petites mises à jour sur les diapositives. Objectif : Découvrir les accords permettant aux auteur-es UNIGE de publier leurs recherches en Open Access sans frais ou à moindre coût, ainsi que leurs conditions d’application. Programme/Contenus : Présenter l'évolution de la publication scientifique avec l'émergence de nouveaux types d'accords avec les éditeurs Identifier les enjeux des négociations nationales Localiser les informations sur les accords et les conditions applicables pour la prise en charge (complète ou partielle) des frais.
description: Une version anglaise de ce support existe : https://doi.org/10.5281/zenodo.7729097
title: Zum Verhältnis von Völkerrecht und innerstaatlichem Recht in der Schweiz: Status quo und aktuelle Diskussionslinien
Creators: name: Epiney, Astrid
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2014
Subjects: subject: 341

description: Völkerrechtsblog
The clustering of luminous red galaxies around Mg II absorbers
Creators: name: Bouché, Nicolas
name: Murphy, Michael
name: Péroux, Céline
Publisher: name: Swinburne
Year: 2024

description: We study the cross-correlation between 212 Mg ii quasar absorption systems and ∼20 000 luminous red galaxies (LRGs) selected from the Sloan Digital Sky Survey Data Release 1 in the redshift range 0.4 ≤z≤ 0.8 . The Mg ii systems were selected to have λλ 2796 and 2803 rest-frame equivalent widths ≥1.0 Å and identifications confirmed by the Fe iiλ2600 or Mg iλ2852 lines. Over comoving scales 0.05–13 h−1 Mpc , the Mg ii–LRG cross-correlation has an amplitude 0.67 ± 0.09 times that of the LRG–LRG auto-correlation. Since LRGs have halo masses greater than 3.5 × 1012 M⊙ for MR≲−21 , this relative amplitude implies that the absorber host galaxies have halo masses greater than ∼2–8 × 1011 M⊙ . For 1013-M⊙ LRGs, the absorber host galaxies have halo masses ∼0.5–2.5 × 1012 M⊙ . Our results appear consistent with those of Steidel, Dickinson & Persson (1994) who found that Mg ii absorbers with WMg IIr≥ 0.3 Å are associated with ∼ 0.7L*B galaxies.
Models for Automatic Musical Composition
Creators: name: Luque-Heredia, Ignacio
Publisher: name: Zenodo
Year: 1994
Subjects: subject: Musicology
subject: Artificial intelligence

description: The engineering thesis, "Models for Automatic Musical Composition," explores the evolution of automatic music composition, focusing on key algorithms and apparatus. It offers an in-depth review of advancements from Guido of Arezzo's "Micrologus" and Athanasius Kircher's "Arca Musarithmica" to 18th-century musical games (musikalisches würfelspiel), culminating in Winkel's 19th-century musical automaton, the "Componium." The study delves into 20th-century information theory applications, highlighting the first computer implementation in the "Illiac," and examines formal grammar experiments of the Chomskian kind.

The second part analyzes power density spectral analysis of classical compositions, emphasizing their 1/f characterization ("pink" musical structures) and its correlation with the prediction-surprise binomial (Clarke Voss's musicality criterion), which is crucial to any musical language. Finally, the third part implements these concepts into automatic music generation systems using multilayer recurrent perceptrons (neural networks), producing compositions beautifully performed and recorded by pianist Rafael Lamas.

Presented in 1994 at the Technical University of Madrid's School of Telecommunications Engineering, the thesis was awarded the highest mark by a jury of distinguished professors. It later received the Best Engineering Thesis prize from Spain’s National Radio and Television and the Official College of Telecommunication Engineers.
Investigating the role of genomic drivers of MET pathway dysregulation in the heterogeneity of Pleomorphic Lung Carcinoma
Creators: name: Januszewski, Adam
Publisher: name: Imperial College London
Year: 2019

description: Background: Pleomorphic Lung Carcinoma (PC) is a rare lung cancer that is aggressive and poorly responsive to treatments. It is a highly heterogenous tumour and unique as it has at least 10% dedifferentiated sarcomatoid component alongside its epithelial components. Recent data have demonstrated a high frequency of mutations in the MET receptor that may support epithelial to mesenchymal transition (EMT) as an important pathway in PCs oncogenesis. The hypothesis was that MET, along with other key components of the MET pathway, would be dysfunctional and exhibit damaging aberrations. Methods: 80 cases of PC were identified from the biobank and diagnostic archives of the Royal Brompton Hospital and Imperial College Healthcare NHS trusts. FFPE sections were obtained and DNA was isolated from histologically distinct areas and epithelial and sarcomatoid areas. Differences in the mutational and expression profiles of a select set of genes/proteins of these areas were determined. Correlative analyses were performed with the genetic and expression profiles against clinicopathological features. Biomarkers of the MET pathway were evaluated with immunohistochemistry and MET copy number was determined with ddPCR. Ultra-deep next generation sequencing was performed on a gene panel selected from earlier findings in PC or that play a role in MET signalling (including MET, KRAS, CBL and HGF). Results: This cohort was comparable to that of other PC studies in terms of patient survival and other clinical characteristics. Median OS was poor (16.3 months) and predicted by tumour size, nodal status and composite stage (P=0.04; 0.008; 0.01). The most commonly mutated genes were TP53 (55%) and KRAS (27%). PCs with paired samples from across both phenotypic components shared oncogenic drivers although differing frequencies of TP53 LOH and KRAS activating mutations were observed. KRAS mutations were mutually exclusive to MET mutations (P=0.03). MET pathway aberrations were present in 44% of cases where there was an increase in MET copy number or MET mutations. MET copy number was significantly higher in the sarcomatoid component (P=0.046). Novel CBL deletions were present in 9.6% of PCs and HGF mutations were present in 8.2% of PCs, albeit at low frequency. There was a significant increase in PD-L1 expression across PCs with higher expression in the sarcomatoid components (p = 0.001). Conclusions: The frequency of alleles with TP53 and KRAS mutations supports the development of PC from an early totipotent progenitor with potential to develop into an epithelial or sarcomatoid tumour. PCs have frequent aberrations of the MET pathway and novel CBL deletions and HGF mutations that warrant further investigation.
Towards a Neo-Blochian Theory of Complexity, Hope and Cinematic Utopia
Creators: name: Hammond, Craig
Publisher: name: figshare
Year: 2016
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: The thesis sketches-out three main and general philosophical, analytical and utopian-strategic areas: Initially, the project begins with a cumulative overview (i.e. drawing upon a collection of authors and publications) of the Marxist philosopher of hope and utopia Ernst Bloch, and, the Blochian philosophical framework. I focus upon, and, analyse several specific philosophical areas within the Blochian framework, notably, those of the chaos of the trace, and Bloch’s unifying (unfolding, trans-historical) category of Hope and Utopia. In order to navigate this difficult philosophical terrain, the thesis proposes several conceptual and neologistic “inventions” – associated with chaos and complexity – so as to invoke a potentially useful (neo)-Blochian philosophical vocabulary. The project then applies Bloch and the Blochian utopian framework to the specific area of popular film/cinema (and, within this, the portrayal of “beautiful monsters”). The neo-Blochian concepts are then applied to utopian cinematic metaphors, images and themes concerning “beautiful monsters”; in exploration of this, I embark upon several contra-punctive Blochian (and, neo-Blochian) analyses of a selection of popular films
Tableau-based protein substructure search using quadratic programming
Creators: name: Stivala, Alexander
name: Wirth, Anthony
name: Stuckey, Peter J.
Publisher: name: Swinburne
Year: 2024

description: Background: Searching for proteins that contain similar substructures is an important task in structural biology. The exact solution of most formulations of this problem, including a recently published method based on tableaux, is too slow for practical use in scanning a large database.
Results: We developed an improved method for detecting substructural similarities in proteins using tableaux. Tableaux are compared efficiently by solving the quadratic program (QP) corresponding to the quadratic integer program (QIP) formulation of the extraction of maximally-similar tableaux. We compare the accuracy of the method in classifying protein folds with some existing techniques.
Conclusion: We find that including constraints based on the separation of secondary structure elements increases the accuracy of protein structure search using maximally-similar subtableau extraction, to a level where it has comparable or superior accuracy to existing techniques. We demonstrate that our implementation is able to search a structural database in a matter of hours on a standard PC.
title: Völkerrecht von und für nicht-staatliche Handelnde: Das Beispiel des Einsatzes von Geneva Call für die Einhaltung humanitärer Regeln durch bewaffnete Gruppen
Creators: name: Sassòli, Marco
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2014
Subjects: subject: 341

description: Völkerrechtsblog
Ionic Liquid-based Extraction of Sulfur Compounds From Gasoline as a Complementary Process to Oxidative Desulfurization
Creators: name: N. Farzin Nejad
name: E. Shams
name: M. K. Amini
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: The extractive desulfurization of a model and several real gasoline samples was investigated using imidazolium-based ionic liquids (ILs). Factorial design of experiments indicated that, among several process variables, the number of extraction steps and the IL/gasoline volume ratio were statistically highly significant. The results showed a desulfurization efficiency of 95.2% under the optimal conditions. The following order was observed for the extraction of thiophenic compounds: benzothiophene>thiophene>3-methylthiophene>2-methylthiophene, with 96.1% removal efficiency for the first one. The IL extraction was applied as a complementary process for the oxidative desulfurization by hydrogen peroxide and formic acid, which provided high efficiency and selectivity for desulfurization of gasoline.
Molecular fraction limits in damped Lyman α absorption systems
Creators: name: Curran, S. J.
name: Murphy, Michael
name: Pihlström, Y. M.
name: Webb, J. K.
name: Bolatto, A. D.
name: Bower, G. C.
Publisher: name: Swinburne
Year: 2024

description: We have used the Green Bank Telescope (GBT) and Berkeley-Illinois-Maryland Association (BIMA) array to search for redshifted millimetre absorption in a sample of damped Lyman alpha absorption systems (DLAs). This increases the number of published systems searched from 18 to 30. In 17 cases we reach 3sigma limits of tau less than or equal to 0.1, which is a significant improvement over the previous searches and more than sufficient to detect the four known redshifted millimetre absorbers (tau greater than or similar to 1). Although the CO rotational (millimetre) column density limits obtained are weaker than the electronic (optical) limits, they may provide useful limits below the atmospheric cut-off for the Lyman and Werner H-2 bands in the UV (z(abs) less than or similar to 1.8). Using a model for the DLA metallicity evolution combined with assumed HCO+/H-2 and CO/H-2 conversion ratios, we use the molecular column density limits to calculate plausible H-2 molecular fraction limits. Finally, we use these results to discuss the feasibility of detecting rotational CO transitions in DLAs with the next generation of large radio telescopes.
Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative
Creators: name: Abolghasem Moghimi
name: Siyavash Rahmani
name: Zare, Reza
name: Sadeghzadeh, Morteza
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorized

description: The main goal of this article is to the present research on the development of ketamine derivatives. The target molecule was a fluoroderivative of ketamine, for which a multistep synthesis has been reported. This novel ketamine derivative, 2-(2-fluorophenyl)-2-methylamino-cyclohexanone, has been called fluoroketamine by our research group. The starting fluorobenzonitrile was reacted with the appropriate Grignard reagent followed by the bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at −40 °C then resulted in the formation of α-hydroxycyclopentyl-(2-flourophenyl)-N-methylamine. Finally, the five-memberd ring cyclopentanol was expanded to the cyclohexylketone by a thermal rearrangement reaction. The HCl salt of the target molecule, which is soluble in water, was obtained by the acidification of the free fluoroketamine with HCl. Preliminary animal tests on mice have shown that the resulting fluoroketamine has some advantages over ketamine in terms of the effective dose and the recovery time.
Determining Permeability Anisotropy From a Core Plug Using a Minipermeameter
Creators: name: Young, Gordon Robert
Publisher: name: The University of Texas at Austin
Year: 1989
Subjects: Permeability
Minipermeameter
Relative Permeability
Core plug

description: The steady-state continuity equation for a real gas is solved using finitedifferences with the boundary conditions for a minipermeameter having an elliptical or circular injection tip seal. The resulting pseudo-potential distribution for the cylindrical domain of a core plug sample is obtained for various permeability ratios. Geometric factors are then calculated by numerically integrating the mass fluxes at the inlet surface inside the injection tip seal. Using a generalized form of Darcy's law, the geometric factors, and data from minipermeameter measurements, estimates of the permeability ratio of four core plug samples are obtained using the geometric factor ratio approach assuming planar isotropy. Finally, quantitative estimates of kx and ky are calculated based on an elliptical and four circular tip seals.
A Front Tracking Model for Thermal Oil Recovery Processes
Creators: name: Kocberber, Sait
Publisher: name: The University of Texas at Austin
Year: 1992
Subjects: Thermal oil recovery
Front tracking
Sweep efficiency

description: A versatile, three-dimensional finite element front tracking model is developed for thermal recovery processes The model approximates the flow domain as regions of homogeneous fluid properties separated by a sharp front and places the primary computational effort on tracking the movement of this front. Flow is approximated as a succession of steady-states based on incompressible fluid flow. Laplace's equation, which is the governing partial differential equation· in each region, is solved by a finite element method subject to exterior and frontal boundary conditions that are dictated by continuity of pressures and conservation of mass and energy across the front. At each time step, normal velocities at the front are calculated and the front is moved explicitly according to these velocities. Since the model treats both condensing and non-condensing fronts as moving discontinuities, continuous alignment of the finite element grid with the front is needed. For this a three-dimensional adaptive grid redistribution scheme has been developed. The model has been tested for accuracy with available data in literature and seems to to provide accurate, dispersion-free numerical solutions with relatively small computing power. The usefulness of the model to simulate e~ects of viscous and gravitational forces, and condensation on displacements in various reservoir/well configurations has been demonstrated. Preliminary sweep efficiency correlations and flooding patterns are provided which can be combined with predictive models to evaluate the performance of thermal recovery processes. This model has the potential to inexpensively simulate field-scale thermal recovery processes such as steam injection and in-situ combustion in heterogeneous reservoirs.
Ionic Liquid-based Extraction of Sulfur Compounds From Gasoline as a Complementary Process to Oxidative Desulfurization
Creators: name: N. Farzin Nejad
name: E. Shams
name: M. K. Amini
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: The extractive desulfurization of a model and several real gasoline samples was investigated using imidazolium-based ionic liquids (ILs). Factorial design of experiments indicated that, among several process variables, the number of extraction steps and the IL/gasoline volume ratio were statistically highly significant. The results showed a desulfurization efficiency of 95.2% under the optimal conditions. The following order was observed for the extraction of thiophenic compounds: benzothiophene>thiophene>3-methylthiophene>2-methylthiophene, with 96.1% removal efficiency for the first one. The IL extraction was applied as a complementary process for the oxidative desulfurization by hydrogen peroxide and formic acid, which provided high efficiency and selectivity for desulfurization of gasoline.
Anomalous weak values and contextuality: Robustness, tightness, and imaginary parts_code
Creators: name: Kunjwal, Ravi
name: Lostaglio, Matteo
name: Pusey, Matt
Publisher: name: Zenodo
Year: 2019
Subjects: Quantum foundations
Contextuality
Weak measurements
Weak values
Quantum mechanics

description: This worksheet implements the algorithmic approach to witness contextuality from anomalous weak values from the paper "Anomalous weak values and contextuality: Robustness, tightness, and imaginary parts" Ravi Kunjwal, Matteo Lostaglio, and Matthew F. Pusey Phys. Rev. A 100, 042116 – Published 21 October 2019 Link: https://journals.aps.org/pra/abstract/10.1103/PhysRevA.100.042116 arXiv: https://arxiv.org/abs/1812.06940
Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative
Creators: name: Abolghasem Moghimi
name: Siyavash Rahmani
name: Zare, Reza
name: Sadeghzadeh, Morteza
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: The main goal of this article is to the present research on the development of ketamine derivatives. The target molecule was a fluoroderivative of ketamine, for which a multistep synthesis has been reported. This novel ketamine derivative, 2-(2-fluorophenyl)-2-methylamino-cyclohexanone, has been called fluoroketamine by our research group. The starting fluorobenzonitrile was reacted with the appropriate Grignard reagent followed by the bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at −40 °C then resulted in the formation of α-hydroxycyclopentyl-(2-flourophenyl)-N-methylamine. Finally, the five-memberd ring cyclopentanol was expanded to the cyclohexylketone by a thermal rearrangement reaction. The HCl salt of the target molecule, which is soluble in water, was obtained by the acidification of the free fluoroketamine with HCl. Preliminary animal tests on mice have shown that the resulting fluoroketamine has some advantages over ketamine in terms of the effective dose and the recovery time.
title: PR-Problem oder Clash of Cultures?: Die Scheuklappen gegen internationales Antidiskriminierungsrecht müssen endlich runter
Creators: name: Liebscher, Doris
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2014
Subjects: subject: 341

description: Völkerrechtsblog
[SPOR Evidence Alliance] Co-building Patient and Public Capacity in Knowledge Synthesis: Designed and Delivered by Patient and Public Partners for Patient and Public Partners
Creators: name: SPOR Evidence Alliance
name: Tricco, Andrea
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Public Health
subject: Medicine and Health Sciences
subject: Public Affairs, Public Policy and Public Administration
subject: Health Policy
subject: Social and Behavioral Sciences
subject: Sociology
subject: FOS: Sociology
subject: Civic and Community Engagement
subject: COVID-19
subject: co-creation
subject: education
subject: evidence synthesis
subject: knowledge synthesis
subject: patient and public involvment
subject: patient engagement
subject: patient-oriented research
subject: rapid reviews

description: The SPOR Evidence Alliance is a pan-Canadian research initiative established in 2017 to address gaps in the production of decision-maker driven knowledge synthesis, as well as development, distribution, and adoption of guidelines in clinical and public health practices. The central aim of the initiative is to foster a collaborative and coordinated approach to building a patient-oriented learning and responsive health system in Canada.
Synthesis of 2-(2-Fluorophenyl)-2-Methylamino-Cyclohexanone as a New Ketamine Derivative
Creators: name: Abolghasem Moghimi
name: Siyavash Rahmani
name: Zare, Reza
name: Sadeghzadeh, Morteza
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: The main goal of this paper was to the present research on the development of ketamine derivatives. The target molecule was a fluoro derivative of ketamine; for which a multistep synthesis has been reported. This novel ketamine derivative, 2-(2-fluorophenyl)-2-methylamino-cyclohexanone, has been called fluoroketamine by our research group. The starting fluorobenzonitrile was reacted with the appropriate Grignard reagent followed by the bromination reaction to obtain α -bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at −40 °C then resulted in the formation of α -hydroxycyclopentyl-(2-flourophenyl)-N-methylamine. Finally, the five-memberd ring cyclopentanol was expanded to the cyclohexylketone by a thermal rearrangement reaction. The HCl salt of the target molecule which is soluble in water, was obtained by the acidification of the free fluoroketamine with HCl. Preliminary animal tests on mice have shown that the resulting fluoroketamine has some advantages over ketamine in terms of the effective dose and the recovery time.
Cosmological evolution of heavy-element and H 2 abundances
Creators: name: Curran, S. J.
name: Webb, J. K.
name: Murphy, Michael
name: Carswell, R. F.
Publisher: name: Swinburne
Year: 2024

description: Spectroscopic observations of distant quasars have resulted in the detection of molecular hydrogen in intervening damped Lyman alpha absorption clouds (DLAs). We use observations compiled from different experimental groups to show that the molecular hydrogen abundance exhibits a dramatic increase over a cosmological time period corresponding to 13 to 24 per cent of the age of the Universe. We also tentatively show that the heavy-element abundances in the same gas clouds exhibit a faster and more well-defined cosmological evolution compared with the general DLA population over the same time baseline. We argue that this latter point is unsurprising, because the general DLA population arises in a wide variety of galaxy types and environments, and thus a spans broad range of ISM gas-phases and abundances at the same cosmic time. DLAs exhibiting H-2 absorption may therefore circumvent this problem, efficiently identifying a narrower class of objects, and provide a more sensitive probe of cosmological chemical evolution.
Further evidence for a variable fine-structure constant from Keck/HIRES QSO absorption spectra
Creators: name: Murphy, Michael
name: Webb, J. K.
name: Flambaum, V. V.
Publisher: name: Swinburne
Year: 2024

description: We have previously presented evidence for a varying fine-structure constant, α, in two independent samples of Keck/HIRES quasi-stellar object (QSO) absorption spectra. Here we present a detailed many-multiplet analysis of a third Keck/HIRES sample containing 78 absorption systems. We also re-analyse the previous samples, providing a total of 128 absorption systems over the redshift range 0.2 < zabs < 3.7. The results, with raw statistical errors, indicate a smaller weighted mean α in the absorption clouds: Δα/α = (-0.574 ± 0.102) × 10-5. All three samples separately yield consistent and significant values of Δα/α. The analyses of low-z (i.e. zabs < 1.8) and high-z systems rely on different ions and transitions with very different dependences on α, yet they also give consistent results. We identify an additional source of random error in 22 high-z systems characterized by transitions with a large dynamic range in apparent optical depth. Increasing the statistical errors on Δα/α for these systems gives our fiducial result, a weighted mean Δα/α = (-0.543 ± 0.116) × 10-5, representing 4.7 σ evidence for a varying α. Assuming that Δα/α = 0 at zabs = 0, the data marginally prefer a linear increase in α with time rather than a constant offset from the laboratory value: α̇/α = (6.40 ± 1.35) × 10-16yr -1. The two-point correlation function for α is consistent with zero over 0.2-13 Gpc comoving scales and the angular distribution of Δα/α shows no significant dipolar anisotropy. We therefore have no evidence for spatial variations in Δα/α. We extend our previous searches for possible systematic errors, giving detailed analyses of potential kinematic effects, line blending, wavelength miscalibration, spectrograph temperature variations, atmospheric dispersion and isotopic/hyperfine structure effects. The latter two are potentially the most significant. However, overall, known systematic errors do not explain the results. Future many-multiplet analyses of independent QSO spectra from different telescopes and spectrographs will provide a now crucial check on our Keck/HIRES results.
A search for high-redshift molecular absorption lines towards millimetre-loud, optically faint quasars
Creators: name: Murphy, Michael
name: Curran, S. J.
name: Webb, J. K.
Publisher: name: Swinburne
Year: 2024

description: We describe initial results of a search for redshifted molecular absorption towards four millimetre-loud, optically faint quasars. A wide frequency bandwidth of up to 23 GHz per quasar was scanned using the Swedish-ESO Submillimetre Telescope at La Silla. Using a search list of commonly detected molecules, we obtained nearly complete redshift coverage up to z(abs) = 5. The sensitivity of our data is adequate to have revealed absorption systems with characteristics similar to those seen in the four known redshifted millimetre-band absorption systems, but none were found. Our frequency-scan technique nevertheless demonstrates the value of wide-band correlator instruments for searches such as these. We suggest that a somewhat larger sample of similar observations should lead to the discovery of new millimetre-band absorption systems.
Relationship of diversity and habitat area in North Pacific plastic-associated rafting communities.
Creators: name: Goldstein, Miriam
Publisher: name: figshare
Year: 2014
Subjects: subject: Environmental Science
subject: Oceanography
subject: FOS: Earth and related environmental sciences

description: This is an author-generated, self-archived version. The final publication is available at link.springer.com. DOI: 10.1007/s00227-014-2432-8 Link: http://link.springer.com/article/10.1007/s00227-014-2432-8 Bibliographic info: Goldstein, M.C., H.S. Carson, and M. Eriksen. 2014. Relationship of diversity and habitat area in North Pacific plastic-associated rafting communities. Marine Biology, published online 13 April 2014. DOI: 10.1007/s00227-014-2432-8.
A 22-GHz search for molecular absorption at z ∼ 3 with the upgraded ATCA
Creators: name: Curran, S. J.
name: Murphy, Michael
name: Webb, J. K.
name: Pihlström, Y. M.
Publisher: name: Swinburne
Year: 2024

description: We report a λ. ≲ 1 cm search for rotational molecular absorption towards quasars, now possible with the upgraded Australia Telescope Compact Array (ATCA). The targets were PKS 0201+113, PKS 0336-017 and Q 0537-286, where known damped Lyman-alpha absorption systems (DLAs) could cause redshifted molecular absorption in the 12-mm band of the telescope. We place 3σ upper limits on any HCO+ 0 → 1 absorption features of <30 mJy per 3.4 km s-1 channel. The non-detections could be attributed to the inherent low metallicities in DLAs leading to generally low H2, and thus HCO+, column densities. In general, the detection of molecular rotational transitions in DLAs could be further hindered by a lower than expected CO-to-H2 conversion ratio, whether due either to photoionization of carbon or to its relative under-abundance at high redshift.