Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Creators: name: Weisenberger, Daniel J.
name: Shelton, Candace
name: Meyerson, Matthew
name: Cibulskis, Carrie
name: Liu, Jia
name: Armenia, Joshua
name: Yau, Christina
name: Maglinte, Dennis T.
name: Akbani, Rehan
name: Van Den Berg, David J.
name: Schultz, Nikolaus
name: Anderson, Matthew L.
name: Mariamidze, Armaz
name: Karlan, Beth Y.
name: Radenbaugh, Amie J.
name: Thompson, Eric
name: Wilkerson, Matthew D.
name: Sun, Qiang
name: Sanchez-Vega, Francisco
name: Newton, Yulia
name: Akeredolu, Teniola
name: Zenklusen, Jean C.
name: Ingram, Davis R.
name: Appelbaum, Elizabeth L.
name: Behera, Madhusmita
name: Raut, Chandrajit P.
name: Wu, Ye
name: Meng, Shaowu
name: DiSaia, Phil
name: Riedel, Richard F.
name: Skelly, Tara
name: Lichtenberg, Tara M.
name: Adebamowo, Clement
name: Sofia, Heidi J.
name: Helsel, Carmen
name: van de Rijn, Matt
name: Curley, Erin
name: Cherniack, Andrew D.
name: Naresh, Rashi
name: Dao, Fanny
name: Laird, Peter W.
name: Ittmann, Michael
name: Godwin, Andrew K.
name: Lee, Darlene
name: Schmidt, Heather K.
name: Sander, Chris
name: Lu, Yiling
name: Kim, Jaegil
name: Wyczalkowski, Matthew
name: Cordes, Matthew G.
name: Mose, Lisle E.
name: Ferguson, Martin L.
name: Gehlenborg, Nils
name: Verhaak, Roel
name: Huang, Mei
name: Tong, Pan
name: Parker, Joel S.
name: Mieczkowski, Piotr A.
name: Sica, Gabriel L.
name: Shi, Yan
name: Balasundaram, Miruna
name: Bowlby, Reanne
name: Chudamani, Sudha
name: Bootwalla, Moiz S.
name: Marra, Marco A.
name: Simons, Janae V.
name: Levine, Douglas A.
name: Drill, Esther
name: Madan, Rashna
name: Wrangle, John
name: Roach, Jeffrey
name: Karseladze, Apollon
name: Wang, Jing
name: Novak, Janet E.
name: Chin, Lynda
name: Boyd, Jeff
name: Fedosenko, Konstantin
name: Torres, Keila E.
name: Mungall, Karen
name: Rathmell, W. Kimryn
name: McLellan, Michael D.
name: Sipahimalani, Payal
name: Diao, Lixia
name: Perou, Charles M.
name: Manikhas, Georgy
name: Gay, Carl M.
name: Liu, Eric Minwei
name: Beroukhim, Rameen
name: Bodenheimer, Tom
name: Wong, Winghing
name: Heiman, David I.
name: Mallery, David
name: Bartlett, John
name: Lester, Jenny
name: Gutman, David A.
name: Ramalingam, Suresh S.
name: Auman, J. Todd
name: Yellapantula, Venkata
name: Eschbacher, Jennifer
name: Gastier-Foster, Julie M.
name: Ochoa, Angelica
name: Spellman, Paul
name: Brooks, Denise
name: Magliocco, Anthony
name: Larsson, Erik
name: Liu, Wenbin
name: Jones, Kevin B.
name: Zhang, Hailei
name: Jefferys, Stuart R.
name: Wang, Zhining
name: Ally, Adrian
name: Mayo, Michael
name: Mardis, Elaine R.
name: Wilson, Richard K.
name: Abeshouse, Adam
name: Swanson, Patricia
name: Kalir, Tamara
name: Shih, Juliann
name: Ding, Li
name: Birrer, Michael
name: Hoyle, Alan P.
name: Adebamowo, Sally N.
name: Balu, Saianand
name: Shelton, Troy
name: Wan, Yunhu
name: Pollock, Raphael E.
name: Soloway, Matthew G.
name: Meier, Sam
name: Hoon, Dave B.
name: Carlsen, Rebecca
name: Tarnuzzer, Roy
name: Robertson, A. Gordon
name: Fulton, Lucinda A.
name: Gabriel, Stacey B.
name: Lawrence, Michael S.
name: Defreitas, Timothy
name: Danilova, Ludmila
name: Castro, Patricia
name: Salner, Andrew
name: Demicco, Elizabeth G.
name: Getz, Gad
name: Chuah, Eric
name: Boice, Lori
name: Zhang, Jiashan (Julia)
name: Hoadley, Katherine A.
name: Weinstein, John N.
name: Dottino, Peter
name: Doyle, Leona A.
name: Felau, Ina
name: Jones, Steven J.M.
name: Gordienko, Elena
name: Brohl, Andrew S.
name: Fulton, Robert S.
name: Gao, Jianjiong
name: Frazer, Scott
name: Paklina, Oxana
name: Perou, Amy H.
name: Lee, Sanghoon
name: Ramirez, Nilsa C.
name: Cope, Leslie
name: Byers, Lauren
name: Sadeghi, Sara
name: Shmulevich, Ilya
name: Li, Irene
name: Dubina, Michael
name: Morris, Scott
name: Thiessen, Nina
name: Belyaev, Dmitry
name: Wong, Tina
name: Voet, Doug
name: Kundra, Ritika
name: Moore, Richard A.
name: Reilly, Colleen
name: Schein, Jacqueline E.
name: Hutter, Carolyn M.
name: Davis, Ian J.
name: Anur, Pavana
name: Singer, Samuel
name: Nalisnik, Michael
name: Davis, Lara E.
name: Shen, Ronglai
name: Bocklage, Thèrése
name: Hegde, Apurva M.
name: Thorne, Leigh B.
name: Roszik, Jason
name: Tam, Angela
name: Jones, Corbin D.
name: Ladanyi, Marc
name: Baker, Laurence
name: Maki, Robert G.
name: Bowen, Jay
name: Lehmann, Kjong-Van
name: Tan, Donghui
name: Potapova, Olga
name: Parfitt, Jeremy
name: Pereira, Elena
name: Noble, Michael S.
name: Pastore, Alessandro
name: Leraas, Kristen M.
name: Lazar, Alexander J.
name: Dhalla, Noreen
name: Pihl, Todd
name: Heins, Zachary
name: Martinez, Cathleen
name: Iype, Lisa
name: Gao, Qingsong
name: Demetri, George D.
name: Lolla, Laxmi
name: Mills, Gordon B.
name: Zhang, Hongxin
name: Saksena, Gordon
name: Demchok, John A.
name: Higgins, Kelly
name: Cooper, Lee A.D.
name: Hayes, D. Neil
name: Voronina, Olga
name: Senbabaoglu, Yasin
name: Mozgovoy, Evgeny
name: Barthel, Floris P.
name: Chen, Hsiao-Wei
name: Hepperla, Austin J.
name: Zmuda, Erik
name: Owonikoko, Taofeek K.
name: Mungall, Andrew J.
name: Wise, Lisa
name: Schumacher, Steven E.
name: Kuo, Hanluen
name: Gutmann, David H.
name: Hobensack, Shital
name: Hu, Xin
name: Chibon, Fréderic
name: Bailey, Matthew H.
name: Reynolds, Sheila M.
name: Delman, Keith
name: Grilley-Olson, Juneko E.
name: Martignetti, John A.
name: Miller, Christopher A.
name: Holt, Robert A.
name: Lai, Phillip H.
name: Penny, Robert
name: Setdikova, Galiya
name: Paulauskis, Joseph
name: Baylin, Stephen B.
name: Kasaian, Katayoon
name: Yang, Liming
name: Van Tine, Brian A.
name: Bennett, Joesph
name: Fulidou, Victoria
name: Godwin, Eryn M.
name: Veluvolu, Umadevi
name: Sekhon, Harman
name: Iacocca, Mary
name: Socci, Nicholas
name: Rubin, Brian P.
name: Ma, Yussanne
name: Hornick, Jason L.
name: Lin, Pei
name: Fronick, Catrina C.
name: Gerken, Mark
name: Crain, Daniel
name: Benz, Christopher
name: Olvera, Narciso
name: Cho, Juok
name: Gardner, Johanna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (, , ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types.