cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Peptides and Peptide Dendrimers as Drug Delivery and Anticancer Agents
Creators: name: Zakharova, Elena
Publisher: name: Universität Bern
Year: 2023
Subjects: subject: 540 Chemistry
subject: 570 Life sciences; biology

description: Peptides are compounds, that are involved in a wide range of biological applications. Use of peptides in cancer therapy can become an alternative strategy to conventional chemotherapy, which is often complicated by increased resistance and detrimental side effects. In the beginning of this thesis, a general introduction gives short overview of current problems of cancer treatment (Chapter 1). The experimental work is divided into two parts. In the first part, we investigated peptides and peptide dendrimers as possible delivery vectors for chemotherapy drugs such as doxorubicin and 1,2-diaminocyclohexane-Platinum(II) (Chapters 2 and 3). We designed suitable drug delivery strategies and assessed the anticancer activity of conjugates.
In the second part, we aimed to develop different peptidic molecules, which can directly act as anticancer agents. By using machine learning approaches, we generated linear, non-hemolytic anticancer peptides (Chapter 4). Further biological evaluations revealed membranolytic and mitochondria targeting properties of selected anticancer peptides. In the Chapter 5 we reported for the first time anticancer properties of peptide dendrimers and presented our attempts to build peptide dendrimers with so-called “isopeptide bonds”.
How I Write (II)
Creators: name: Gillespie, Alexandra
Publisher: name: punctum books
Year: 2015

description: I only write when I have to. Because reasons. It’s just the way I write.I used to invent the necessity in “have to.” “How will you fund the fourth year of your DPhil?” asked my graduate super-visor in October 1997. I was 23, fresh from an undergraduate degree; I had little Latin, less Greek. (Ha ha! I had no Greek.) I hadn’t read much English literature, come to think of it. “Iwill finish in three years,” I told her. “Good,” she said.And because I had said it, I did it. Well, sort of: by October 2000 my thesis existed — not great, but fully footnoted at least.
This Would Be Better If I Had A Co-Author
Creators: name: Mittman, Asa Simon
Publisher: name: punctum books
Year: 2015

description: This would be better if I had a co-author. Of course it would. This would mean a few things (ideally, and assuming that all went according to plan):–We’d have had a conversation before starting to write, before outlining, about what the essay should look like, how it should be framed and organized, and what it might accom-plish. As is, I’ve just had that conversation bouncing around in my head while trying to fall asleep for the last few nights. I think best in dialog, often only articulating for myself what I want to say when I try to explain it to someone else. Collaborative writing is a sustained conversation.
Brief an Luise, Raugräffin zu Pfaltz à Frankforth
Creators: name: Orléans, Elisabeth Charlotte d'
Publisher: name: [s.n.]
Year: 1721

description: Schreibt, dass sie die ganze Nacht schweres Fieber gehabt habe und zu sterben glaubte
description: von Elizabeth Charlotte, genannt "Lieselotte", Gemahlin des Herzogs Philipp von Orléans, Bruder Ludwig XIV
description: Mit rotem Lacksiegel
description: Eigenhändiges Schreiben mit Unterschrift
description: Stiftung Sammlung Karl Geigy-Hagenbach
description: Deutsch
description: Hans F. Helmolt, Verzeichnis Nr. 3577. - Druck: ed. W.L. Holland (Bibl.l.t.Verein Bd. 157), tübingen 1881, Nr. 1193
description: Verzeichnung=Description=Inventaire März 2015 HAN-Katalogisierungsregeln Rekatalogisierung nach Original, Verzeichnis von Karl Geigy-Hagenbach und Briefkatalog der UB Basel
How I Write (III)
Creators: name: Nolan, Maura
Publisher: name: punctum books
Year: 2015

description: I direct a campus-wide program called Berkeley Connect that began in the English Department, in which advanced graduate students mentor undergraduates one-on-one and in groups to create a small-college experience at our large research university. In any given semester, we have a number of public events for participants that focus on bringing faculty, graduate students, and undergraduates closer together, as people engaged in the same enterprise at different levels. One of our most successful events is a panel we have done several times, called “How I Write.” We ask five department faculty and graduate students to speak for ten minutes each about their writing practices — not how to be better writers, or how to organize papers, or how to come up with a thesis, or how to do research, but what they actually do when they sit down at their computers or desks with a blank screen or page in front of them. Students love hearing about the crazy things their mentors and professors do to make themselves write. One graduate student reported tying himself to his desk chair with his bathrobe belt so he couldn’t get up and walk around. Others had elaborate systems for keeping score of words, paragraphs, pages, footnotes, and chapters written, with rewards for each type of accomplishment. What means the most to students, however — and what is the biggest revelation to them — is the fact that these experts on English literature all struggle with writing. As teachers, none of us had realized the extent to which our undergraduates assumed that being an English graduate student or an English professor, and thus a proven success at literary criticism, meant that writing must be very easy for you.
Errant Practices
Creators: name: Godden, Richard H.
Publisher: name: punctum books
Year: 2015

description: These words were painful to write. They haunt me, and have done so my entire academic career. Ok, that is not entirely true. I made it through my first two years of college on pure bluster, but once I needed to write, to do more than toss off a handful of pages in a single night, I became haunted. I spent most of the second half of college and, frankly, all of my graduate career feeling like I had skipped a year of schooling. I had gone away, I know not where, and when I came back, everyone was doing long division and I was scrambling to figure out what I missed. Why was I never taught how to write properly? Why did I never learn? Why do I struggle so much?
Writing By Accumulation
Creators: name: Elden, Stuart
Publisher: name: punctum books
Year: 2015

description: Generally the advice I give on writing has been along the lines of saying “there is no one correct way to write, but there are plenty of ways people seem to be stuck in that are not working well for them.” This can then lead into a discussion of different people’s writing strategies, with their peculiarities, conventions, strengths and weaknesses, which may suggest things that others might find helpful, or at least worth giving a try. Such events — workshops on publishing or writing, for example — can be really helpful, and to put something similar down in book form seems a really good idea. I certainly don’t want to suggest that I always get it right with my own writing, and (although people seem to have a different impression) I find writing hard. My solution to this, such as it is, is to build writing up slowly, in small manageable pieces, a little-by-little approach that can develop over time into something. And I suppose, when pressed, this is the advice I dogive people, especially my students: do not defer writing to some point in the future, and write regularly. I admire people who seem to be able to turn on the “writing switch,” and produce large quantities of material in intense bursts of creativity. But that rarely works for me, and so I’ve worked out a different approach. It’s not like pushing pebbles off a cliff, but slowly rolling them up one, to form a small but growing pile; where frequently pebbles will be removed, polished, and rearranged, and sometimes replaced or discarded. Over time the pebbles become something, or the pile gets raided for a different pile.
Viscous Dark Energy in $f(T)$ Gravity
Creators: name: Sharif, M.
name: Rani, Shamaila
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the bulk viscosity taking dust matter in the generalized teleparallel gravity. We consider different dark energy models in this scenario along with a time dependent viscous model to construct the viscous equation of state parameter for these dark energy models. We discuss the graphical representation of this parameter to investigate the viscosity effects on the accelerating expansion of the universe. It is mentioned here that the behavior of the universe depends upon the viscous coefficients showing the transition from decelerating to accelerating phase. It leads to the crossing of phantom divide line and becomes phantom dominated for specific ranges of these coefficients.
description: 17 pages, 12 figures
Brief an Unbekannt
Creators: name: Maximilian
Publisher: name: [s.n.]
Year: 1842

description: Dank für dargebrachte Glückwünsche
description: von Maximilian II., König von Bayern
description: Brief von unbekannter Hand mit eigenh. Unterschrift
description: Stiftung Sammlung Karl Geigy-Hagenbach
description: Deutsch
description: Verzeichnung=Description=Inventaire März 2015 HAN-Katalogisierungsregeln Rekatalogisierung nach Original, Verzeichnis von Karl Geigy-Hagenbach und Briefkatalog der UB Basel
Insensate Oysters and Our Nonconsensual Existence
Creators: name: Steel, Karl
Publisher: name: punctum books
Year: 2015

description: The earliest version of this paper, deliveredat the Oceanic New York symposium, tried to change the way people normally write about oysters. Oyster books love to talk about pearls and Chesapeake Bay’s oyster war; they love how oyster middens chart the passage not of cavemen but of “covemen,” who followed the beds of oysters around coasts in a kind of gustatory cartogra-phy.2 These same writers happily accept the oyster’s fleshy invitation to aphrodisiacal excess. And when they look to New York City, they love to mourn the loss of its oyster beds, closed by pollution and over-harvesting, perhaps for good, in 1927, once home to trillions of the creatures, a seedbed for nostalgia for the grittier appetites of New York’s presumably populist past.3 I asked us to remember the oyster itself by remembering its shell, calcium carbon-ate, particularly important now to offset the increasing acidification of the oceans; likewise, I asked that we appreciate how prodigiously a living oyster filters water. What they ingest and don’t eat, oysters eject as pseudofeces, which, coated in mucous, fall to the ocean floor to be processed by anoxic bacteria. The cleaner, deacidified water oysters leave behind is what just about everything else needs to live. I wanted us to look to projects to use bring oysters back to New York, like the architect Kate Orff ’s call for “oystertecture,” an “invertebrate architecture” to help abate the force of hurricanes, to keep New York City safe from our future’s inevitable Sandies.
Is space-time symmetry a suitable generalization of parity-time symmetry?
Creators: name: Amore, Paolo
name: Fernández, Francisco M.
name: Garcia, Javier
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss space-time symmetric Hamiltonian operators of the form $% H=H_{0}+igH^{\prime}$, where $H_{0}$ is Hermitian and $g$ real. $H_{0}$ is invariant under the unitary operations of a point group $G$ while $H^{\prime}$ is invariant under transformation by elements of a subgroup $G^{\prime}$ of $G$. If $G$ exhibits irreducible representations of dimension greater than unity, then it is possible that $H$ has complex eigenvalues for sufficiently small nonzero values of $g$. In the particular case that $H$ is parity-time symmetric then it appears to exhibit real eigenvalues for all $% 00$. We illustrate the main theoretical results and conclusions of this paper by means of two- and three-dimensional Hamiltonians exhibiting a variety of different point-group symmetries.
A Short History of the Hudsonian Ice Age
Creators: name: Nowacek, Nancy
name: Duckert, Lowell
Publisher: name: punctum books
Year: 2015

description: Going back to a river’s beginning is not topinpoint its source—it is to begin (again). Time may flow, but a river always escapes the trappings of chronology. Riparian time emphasizes riptides, eddies, and turbulent zones over lines, origins, and laminar points.(All we know are these confluences: Skype chats and emails; poetry and bridge sections; rivers and tides; bendable and multipliable time. Data streams, hover-craft, “Hudson,” Muhheakantuck.)How do we understand a body of water without our own—in it, with it, through it? What will be the stuff of this day’s bridges—of space, time, conversation, question and experi-ence— enlisted to build tomorrow’s? Does the water outside my window know that I’m watching it, wondering where it will go next? Will it love as it is loved?
Wages of Water
Creators: name: Mentz, Steve
Publisher: name: punctum books
Year: 2015

description: This fragment has two parts. The first splashesthrough the Hudson River one early morning in September 2013. The second took place that same fall, on the Monday before Thanksgiving, inside the canal of my left ear.In diving into the “wages” of water I’m not suggesting that the world ocean owes us anything. Nor really the opposite, that we owe the great waters a globe without plas-tic, or with less carbon, much as I love such fanciful ideas. (To clarify: we are heading for a lower-carbon future. The question is whether we’ll burn all the coal and oil in the ground before we get there. That’s what will determine the shape of our catastrophic future.) The wages I’m talking in this case about are personal. Not an ocean inside, though part of this story takes place inside my body. What I’m writing about is salt on skin, the feel and pressure of the world ocean on a fragile individual body, in this case mine. How does it feel, I ask, to touch the hyperobject?
Instructions: In Case of Immersion
Creators: name: Mentz, Steve
name: Zurkow, Marina
Publisher: name: punctum books
Year: 2015

description: The second selection of nine essays opens upflooded streets to global connections.Steve Mentz and Marina Zurkow conspireon instructions for flooded cities.Jeffrey Jerome Cohen revealsthe sea’s conveying motions.Allan Mitchell plunges downinto oceanic and poetic forms.Dean Kritikos invites Jean-Paul Sartreand TimothyMorton to visithis hometown of New York City.Anne Harris values depth, uncertainty, and disaster.Julie Orlemanski explores                                                      what         it         would         take         to         move                                             from         tourism         to         activism.              Jonathan       Hsy slides intothe watery basis of                                             language         and         metaphor.              Nancy       Nowacek narratesher epic story ofbridging Buttermilk Channel.Jeffrey Jerome Cohen                           and         Allan Mitchell                  exchange         dispatches                                    about         the         ocean                                             from         opposite         sidesof a continent.
Numerical relativity meets the small mass ratio limit : assessing the domain of applicability of gravitational self-force
Creators: name: Navarro Albalat, Sergi
name: 0000-0003-2554-7486
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Numerical relativity
Gravitational self-force

description: This dissertation consists of four chapters. The first chapter serves as an introduction to two fundamental techniques that are currently being used to model the two-body problem in General Relativity and a motivation to study their overlap: numerical relativity (NR) and gravitational self-force (GSF), sometimes referred as the small mass ratio (SMR) approximation. The first chapter ends with an illustration of the benefits of studying the NR-GSF overlap with a novel analysis of the gravitational wave phase evolution of a binary black hole (BBH). The remaining chapters correspond to the three main contributions that have originated from my work as a graduate student at the University of Texas at Austin at the interplay of these two techniques. Chapter two is based on work done with my advisor Aaron Zimmerman and collaborators Matthew Giesler and Mark Scheel, where we conducted an analysis of the SMR limit of the so-called redshift factor in NR simulations, a (pseudo)-invariant quantity that has diverse applications when modelling the two-body problem [29]. Chapter three is a collaboration of work with Aaron Zimmerman, Harald Pfeiffer and Antoni Ramos Buades, which extends the redshift analysis in [29] to eccentric equatorial orbits. Chapter four is based on a recently submitted paper [28] with Aaron Zimmerman, Matthew Giesler and Mark Scheel, where we tackle an important limitation of past comparisons between NR and SMR theory by analyzing the evolution of the invariant binding energy and angular momentum during the transition from inspiral to plunge.
The Sea is a Conveyance-Machine
Creators: name: Cohen, Jeffrey Jerome
Publisher: name: punctum books
Year: 2015

description: There came over them the hosts of Portugalto destroy and to exterminate all that is called Israel, children and women in one day.”1 So wrote Isaac Aboab in the first Hebrew poem of the Americas, around 1649. Aboab composed this text in Recife, destined to become a city of Brazil but at the time capital of a fleeting entity called Nieuw-Holland. The port was under siege by the Portuguese, determined to destroy the Jewish commu-nity sheltered there. Born to Marranos fleeing religious persecution, Isaac Aboab and his family had dwelled for a while in France, practicing a reclaimed Judaism. To avoid forced return to Christianity their community migrated to Amsterdam, and then to South America, and to peril.
Detection methods to rule out completely co-positive and bi-entangling operations
Creators: name: Macchiavello, C.
name: Rossi, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work we extend the quantum channel detection method developed in [Phys. Rev. A 88, 042335 (2013)] and [Phys. Script. T153, 014044 (2013)] in order to detect other interesting convex sets of quantum channels. First we work out a procedure to detect non completely co-positive maps. Then we focus on the set of so-called bi-entangling operations and show how a map outside this set can be revealed. In both cases we provide explicit examples showing the theoretical technique and the corresponding experimental procedure.
description: 6 pages, 2 figures
Brief an [Roger Lord] North
Creators: name: Essex, Robert Devereux
Publisher: name: [s.n.]
Year: 1591

description: Eigenhändiger Brief mit Unterschrift
description: Very important autograph letter, concerning the expedition he was preparing to take over to Normandy to help Henry IV against the league
description: von Robert Devereux Essex
description: Essex war der Geliebte der Königin Elisabeth, Lord Lieutenant von Irland, leitete eine Verschwörung gegen Elisabeth, wurde schuldig erkannt und enthauptet
description: Stiftung Sammlung Karl Geigy-Hagenbach
description: Englisch
description: Verzeichnung=Description=Inventaire Juni 2015 HAN-Katalogisierungsregeln Rekatalogisierung nach Original, Verzeichnis von Karl Geigy-Hagenbach und Briefkatalog der UB Basel
Brief an Alexei Petrowitsch
Creators: name: Aleksandr
Publisher: name: [s.n.]
Year: 1876

description: "Ich habe meiner Frau alles, was Sie über den Aufenthalt der Königin und Prinzessin Tyra in Paris schreiben, vorgelesen und es hat sie sehr interessiert ..."
description: von Alexander III.
description: Eigenhändiger Brief mit Unterschrift
description: Stiftung Sammlung Karl Geigy-Hagenbach
description: Russisch
description: Verzeichnung=Description=Inventaire Mai 2015 HAN-Katalogisierungsregeln Rekatalogisierung nach Original, Verzeichnis von Karl Geigy-Hagenbach und Briefkatalog der UB Basel
description: 1 Couvert (11 x 14,5 cm) mit Aufschrift von Bogolubow
Last gasp of a black hole: unitary evaporation implies non-monotonic mass loss
Creators: name: Bianchi, Eugenio
name: Smerlak, Matteo
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show within the usual two-dimensional approximation that unitarity and the restoration of Minkowski vacuum correlations at the end of black hole evaporation impose unexpected constraints on its mass loss rate: before disappearing the black hole emits one or more negative energy burst, leading to a temporary increase of its mass.
description: 8 pages; nontechnical version of 1404.0602
Sustained oral spermidine supplementation rescues functional and structural defects in COL6-deficient myopathic mice
Creators: name: Gambarotto, Lisa
name: Metti, Samuele
name: Corpetti, Matteo
name: Baraldo, Martina
name: Sabatelli, Patrizia
name: Castagnaro, Silvia
name: Cescon, Matilde
name: Blaauw, Bert
name: Bonaldo, Paolo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology

description: COL6 (collagen type VI)-related myopathies (COL6-RM) are a distinct group of inherited muscle disorders caused by mutations of COL6 genes and characterized by early-onset muscle weakness, for which no cure is available yet. Key pathophysiological features of COL6-deficient muscles involve impaired macroautophagy/autophagy, mitochondrial dysfunction, neuromuscular junction fragmentation and myofiber apoptosis. Targeting autophagy by dietary means elicited beneficial effects in both col6a1 null (col6a1–/–) mice and COL6-RM patients. We previously demonstrated that one-month per os administration of the nutraceutical spermidine reactivates autophagy and ameliorates myofiber defects in col6a1–/– mice but does not elicit functional improvement. Here we show that a 100-day-long spermidine regimen is able to rescue muscle strength in col6a1–/– mice, with also a beneficial impact on mitochondria and neuromuscular junction integrity, without any noticeable side effects. Altogether, these data provide a rationale for the application of spermidine in prospective clinical trials for COL6-RM. Abbreviations: AChR: acetylcholine receptor; BTX: bungarotoxin; CNF: centrally nucleated fibers; Colch: colchicine; COL6: collagen type VI; COL6-RM: COL6-related myopathies; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; NMJ: neuromuscular junction; Spd: spermidine; SQSTM1/p62: sequestosome 1; TA: tibialis anterior; TOMM20: translocase of outer mitochondrial membrane 20; TUNEL: terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling.
Measurement and modelling of anomalous polarity pulses in a multi-electrode diamond detector
Creators: name: Forneris, J.
name: Grilj, V.
name: Jaksic, M.
name: Olivero, P.
name: Picollo, F.
name: Skukan, N.
name: Verona, C.
name: Verona-Rinati, G.
name: Vittone, E.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: In multi-electrode detectors, the motion of excess carriers generated by ionizing radiation induces charge pulses at the electrodes, whose intensities and polarities depend on the geometrical, electrostatic and carriers transport properties of the device. The resulting charge sharing effects may lead to bipolar currents, pulse height defects and anomalous polarity signals affecting the response of the device to ionizing radiation. This latter effect has recently attracted attention in commonly used detector materials, but different interpretations have been suggested, depending on the material, the geometry of the device and the nature of the ionizing radiation. In this letter, we report on the investigation in the formation of anomalous polarity pulses in a multi-electrode diamond detector with buried graphitic electrodes. In particular, we propose a purely electrostatic model based on the Shockley-Ramo-Gunn theory, providing a satisfactory description of anomalous pulses observed in charge collection efficiency maps measured by means of Ion Beam Induced Charge (IBIC) microscopy, and suitable for a general application in multi-electrode devices and detectors.
description: 8 pages, 4 figures
AI-based AlphaFold2 significantly expands the structural space of the autophagy pathway
Creators: name: Malhotra, Nidhi
name: Khatri, Shantanu
name: Kumar, Ajit
name: Arun, Akanksha
name: Daripa, Purba
name: Fatihi, Saman
name: Venkadesan, Sureshkumar
name: Jain, Niyati
name: Thukral, Lipi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Computational Biology

description: A structural understanding of entire cellular processes has been an uncharted realm, until now. The artificial intelligence-based tool AlphaFold2 (AF2) has substantially changed the prediction accuracy, and predicted models of entire proteomes are now available. Here, we have examined AF2’s prediction of 38 core macroautophagic/autophagic proteins and 378 interacting partners representing the human autophagic interactome. Prior to AF2, ~50% of the proteins lacked atomistic level resolution and we found significant improvement in structural coverage by AF2, with an addition of ~ 47% of the residues modeled with reasonable confidence. We also augmented this structural information with μs timescale molecular dynamics simulations, in particular, ATG2, ATG10, and ATG14. ATG2A, a bipartite membrane protein with rodlike architecture was predicted with high accuracy and our simulations revealed dynamic transitions of cavity-lining residues that might play a critical role in regulating lipid transfer. In addition, a promising approach of multimeric prediction by AF2 revealed the architecture of ATG7-ATG10, a tetrameric complex that participates in conjugation machinery in autophagy. By combining computational and experimental approaches, we demonstrated that three salt bridges were crucial to ATG7-ATG10 complex formation and mutating these residues abrogated the binding. We have also generated a web resource with curated AF2 structural models, simulated conformational ensemble, and structural analysis that will be highly pertinent to the autophagy community. Altogether, our work presents a robust pipeline to utilize AF2 as a tool for a starting point to provide the dynamic behavior of molecules in a given biological pathway. AF2: AlphaFold2; AF2-Mult: AlphaFold2 multimer; ATG: autophagy-related; CTD: C-terminal domain; ECTD: extreme C-terminal domain; FR: flexible region; MD: molecular dynamics; NTD: N-terminal domain; pLDDT: predicted local distance difference test; UBL: ubiquitin-like
Extending COVID Risk Assessment Models with Ambient Sensors
Creators: name: OR, Wing Hong
Publisher: name: Zenodo
Year: 2022
Subjects: COVID
Airborne risk assessment
Internet of Things (IoT)
Sensor device

description: COVID-19 pandemic has caused great loss in humanity. While its impacts on public health and socio-economy have been less severe, it is important to quantify the risk of infection for decision making. COVID Airborne Risk Assessment Calculator (CARA) is a web interface assessment tool developed by Henriques and colleagues from CERN. This study explores the possibility to extend the model by connecting it to sensors and supplying with updated indoor environmental data, with an ambition to improve the practicality and reliability of the model and create a sensor device that can communicate risk with occupants. In addition, carbon dioxide (CO2) is a common indicator for indoor air quality, ventilation, and even risk for airborne transmissive disease. This study attempts to incorporate data collected from a CO2 sensor for ventilation estimation and supply it as a parameter for the CARA model. Furthermore, a CO2-based transmission model from Rudnick & Milton was deployed for risk assessment with simple set up. This study has shown the feasibility in creating a sensor device for airborne risk assessment using a comprehensive or a simple model. It also promotes risk communication in multiple levels by creating multiple visualizations including sensor display and data dashboard. While focusing on COVID-19, the approach can be extended to other airborne transmissive diseases.
description: {"references": ["Henriques A, Mounet N, Aleixo L, Elson P, Devine J, Azzopardi G, Andreini M, Rognlien M, Tarocco N, Tang J. (2022). Modelling airborne transmission of SARS-CoV-2 using CARA: risk assessment for enclosed spaces. Interface Focus 12: 20210076. doi.org/10.1098/rsfs.2021.0076"]}
Oceanic Valuation
Creators: name: Harris, Anne
Publisher: name: punctum books
Year: 2015

description: A qui appartiendra cebriz?” screechesPanurge as the tempest-tossed ship he clings to heaves and groans towards becoming a wreck.1 To whom does a shipwreck belong? It belongs to the sea: the word is a woeful concession to the mismatch between oceanic power and human hopes and goods.2 “Shipwreck” belongs to its investors: it is also the word that activates and justifies the claims of insurance, that human attempt to negotiate (with) loss. Torn between possession and dispos-session, the shipwreck manifests the struggle to account for things.3Torn asunder, the shipwreck multiplies categories of value. In asking about the reversals of fortune the ocean exacts in its shipwrecks, Panurge’s question insists on the troublesome operations of oceanic valuation: the traumatic ways in which the ocean provokes humans to value things.
Building a Bridge by Hand to Cross Buttermilk Channel on Foot
Creators: name: Nowacek, Nancy
Publisher: name: punctum books
Year: 2015

description: Walt Whitman reports the Barbarossa’spassage through Buttermilk Channel. It is a large German vessel with a draft of 28 feet. He writes an article for the Brooklyn titled, “It’s really a Channel”: “A few years ago moderate sized barks had an unhappy habit, in consort with their towboats, of going aground near the Atlantic Dock gap. There was much recrimination, a good deal of hard swearing, but there was no dispute that there was a [sand]bar in Buttermilk Chan-nel.” Whitman provides an antecedent about the Channel’s name: “the title of Buttermilk Channel is derived from the days of the Revolution when a two gun battery swept the upper bay. The colonists were not over blessed with wealth or food and the farmers drove their cows across the [sand]bar that then led to Governor’s Island. When the cows missed the low tide they had to swim home and as a result their lacteal processes resulted in sour milk. Hence Buttermilk Channel.”
Backmatter
Creators: name: Mentz, Steve  (Ed.)
Publisher: name: punctum books
Year: 2015

description: These four poems end this book as theygesture toward still-unnarrated waters. The poems ask what bodies learn from their encounters with Ocean. They are part of a larger project that explores swimming as an aesthetic practice for our age of ecological catastrophe.The poems respond to this photograph by Vanessa Daws, a Dublin-based visual artist. The image was taken during “Lambay Swim,” a collaborative journey made by the swimmers of Low Rock on 17th June 2014.
Brief an den Obersten v. Boyen
Creators: name: Karl Johann
Publisher: name: [s.n.]
Year: 1813

description: Bedankt sich beim späteren preussischen Feldmarschall und Kriegsminister, dem er für seine Verdienste in der Schlacht bei Dennewitz einen Orden verleiht
description: von Karl Johann XIV., König von Schweden
description: Brief von fremder Hand mit eigenhändiger Unterschrift
description: Stiftung Sammlung Karl Geigy-Hagenbach
description: Französisch
description: Verzeichnung=Description=Inventaire Mai 2015 HAN-Katalogisierungsregeln Rekatalogisierung nach Original, Verzeichnis von Karl Geigy-Hagenbach und Briefkatalog der UB Basel
Brief an [Signor Presidente]
Creators: name: Amadeus
Publisher: name: [s.n.]
Year: 1882

description: Betr. Gotthardbahn
description: von Amadeus I
description: Schöner eigenhändiger Brief mit Unterschrift
description: Stiftung Sammlung Karl Geigy-Hagenbach
description: Italienisch
description: Verzeichnung=Description=Inventaire Mai 2015 HAN-Katalogisierungsregeln Rekatalogisierung nach Original, Verzeichnis von Karl Geigy-Hagenbach und Briefkatalog der UB Basel
An analysis of price-setting generation technologies in the Australian National Electricity Market
Creators: name: Sapkota, Santosh
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Being the most competitive energy source in terms of the levelized cost of electricity, and supported by government policies to reduce carbon emissions, variable renewable energy (VRE) penetration is increasing globally, including in the Australian National Electricity Market (NEM). This research tries to analyse the impact of this change on price-setting technologies in the NEM. The main objective of the research is to broaden the knowledge on price-setting dynamics across different Australian regional electricity markets and to provide a full picture of which technologies set market prices during different scenarios. By analysing the 5-minute dispatch period data from 2009-2021 we found that price-setting in the NEM is typically dominated by black coal generators. Hydropower, gas, and brown coal generators also set electricity prices for significant periods, however, contribution of renewable generators (solar, wind) to price-setting is still almost negligible. By conducting a 90-day rolling window analysis we found that the share of black coal to set electricity prices is decreasing, while the share of renewable has been increasing through time. We found that black coal generators are more likely to set electricity prices during off-peak periods, while gas and hydropower generators set electricity prices more frequently during peak periods. Among the renewable generators, solar is more active to set electricity prices in the middle of the day when sunlight is abundant, while wind generators set electricity prices more frequently in the early morning and at midday. Coal generators contributed most to electricity prices during periods of lower demand levels, while at the highest demand quantile, coal, gas, and hydropower generators are more likely to set electricity prices. Peak load generators such as gas and hydropower were also setting negative electricity prices. The start-up cost of those generators is lower, and the ramp-up rate is higher so, setting negative electricity prices by those peak load plants was an anomaly. Our research found some evidence that this anomaly may have resulted from strategic behaviour of these generators. Our logistic regression confirms most of the findings of our factor analysis. In addition, it shows that black and brown coal generators are more likely to set electricity prices in summer, while hydropower and gas generators are more likely to set electricity prices in winter. During the carbon tax period, the probability of renewable generators to set electricity prices was increased, while that of fossil fuel-based generators was decreased. Similarly, over time, black coal is less likely to set any extreme electricity prices, while wind and gas generators have become more likely to set prices during spike periods. At the same time VRE technologies also have a higher probability to set negative prices.
Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma
Creators: name: Lin, Chiao-Yun
name: Wu, Kai-Yun
name: Chi, Lang-Ming
name: Tang, Yun-Hsin
name: Huang, Huei-Jean
name: Lai, Chyong-Huey
name: Tsai, Chi-Neu
name: Tsai, Chia-Lung
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: SH3PXD2A/TKS5 (SH3 and PX domains 2A) is a scaffold protein that promotes invadopodia formation and regulates cell migration; therefore, the overexpression of SH3PXD2A has been reported in various cancers. However, the molecular mechanisms of the SH3PXD2A-mediated cellular migration signaling pathway remain unknown. Here, we showed that the starvation-induced macroautophagy/autophagy or treatment with the MTOR inhibitor RAD001 elevated SH3PXD2A expression in ovarian cancer cell lines. SH3PXD2A formed a complex with ULK1 (unc-51 like autophagy activating kinase 1) and MTOR, as revealed by co-immunoprecipitation assay. Furthermore, ULK1 affected protein stability by phosphorylating SH3PXD2A at serine residues 112, 142, 146, 147, 175, and 348. Mutation of these six residues in SH3PXD2A reduced ULK1-mediated phosphorylation, blocked SH3PXD2A induction by treatment with RAD001, and reduced its binding to the cell membrane phospholipid phosphatidylinositol-3-phosphate (PtdIns3P) versus recruitment of MMP14 (matrix metallopeptidase 14) in ovarian cancer cells. Finally, the administration of RAD001 induced SH3PXD2A expression in tumor tissues, as revealed by the PDX mouse model. The clinical impact of SH3PXD2A was evaluated in ovarian and endometrial cancers using western blotting. The negative correlation between MTOR-mediated phospho-ULK1 and SH3PXD2A proteins was found in clinical specimen. Furthermore, the TCGA database revealed that the cumulative overall survival of ovarian cancer patients with higher SH3PXD2A RNA/protein expression in tumor lesions was reduced compared to those with lower SH3PXD2A expression. Our results suggest that the ULK1-SH3PXD2A-MMP14 axis might regulate the biological aggressiveness of ovarian cancer and serve as a therapeutic target in this malignancy. AMPK: AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks’ balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1
Performance Impact of Data Layout on the GPU-accelerated IDW Interpolation
Creators: name: Mei, Gang
name: Tian, Hong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: This paper focuses on evaluating the performance impact of different data layouts on the GPU-accelerated IDW interpolation. First, we redesign and improve our previous GPU implementation that was performed by exploiting the feature CUDA Dynamic Parallel (CDP). And then, we implement three versions of GPU implementations, i.e., the naive version, the tiled version, and the improved CDP version, based on five layouts including the Structure of Arrays (SoA), the Array of Sturcutes (AoS), the Array of aligned Sturcutes (AoaS), the Structure of Arrays of aligned Structures (SoAoS), and the Hybrid layout. Experimental results show that: the layouts AoS and AoaS achieve better performance than the layout SoA for both the naive version and tiled version, while the layout SoA is the best choice for the improved CDP version. We also observe that: for the two combined data layouts (the SoAoS and the Hybrid), there are no notable performance gains when compared to other three basic layouts. We recommend that: in practical applications, the layout AoaS is the best choice since the tiled version is the fastest one among the three versions of GPU implementations, especially on single precision.
description: Preprint version for reviewing. 9 pages
New Physics of Metamaterials
Creators: name: Wang, Z. Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: Einstein utilized Lorentz invariance from Maxwell's equations to modify mechanical laws and establish the special theory of relativity. Similarly, we may have a different theory if there exists another covariance of Maxwell's equations. In this paper, we find such a new transformation where Maxwell's equations are still unchanged. Consequently, Veselago's metamaterial and other systems have negative phase velocities without double negative permittivity and permeability can be described by a unified theory. People are interested in the application of metamaterials and negative phase velocities but do not appreciate the magnitude and significance to the spacetime conception of modern physics and philosophy.
Optical Follow-Up Observations of PTF10qts, a Luminous Broad-Lined Type Ic Supernova Found by the Palomar Transient Factory
Creators: name: Walker, E. S.
name: Mazzali, P. A.
name: Pian, E.
name: Hurley, K.
name: Arcavi, I.
name: Cenko, S. B.
name: Gal-Yam, A.
name: Horesh, A.
name: Kasliwal, M.
name: Poznanski, D.
name: Silverman, J. M.
name: Sullivan, M.
name: Bloom, J. S.
name: Filippenko, A. V.
name: Kulkarni, S. R.
name: Nugent, P. E.
name: Ofek, E.
name: Barthelmy, S.
name: Boynton, W.
name: Goldsten, J.
name: Golenetskii, S.
name: Ohno, M.
name: Tashiro, M. S.
name: Yamaoka, K.
name: Zhang, X. L-.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present optical photometry and spectroscopy of the broad-lined Type Ic supernova (SNIc-BL) PTF10qts, which was discovered as part of the Palomar Transient Factory. The supernova was located in a dwarf galaxy of magnitude $r=21.1$ at a redshift $z=0.0907$. We find that the $R$-band light curve is a poor proxy for bolometric data and use photometric and spectroscopic data to construct and constrain the bolometric light curve. The derived bolometric magnitude at maximum light is $M_{\rm bol} = -18.51\pm0.2$ mag, comparable to that of SN 1998bw ($M_{\rm bol} = -18.7$ mag) which was associated with a gamma-ray burst (GRB). PTF10qts is one of the most luminous SNIc-BL observed without an accompanying GRB. We estimate the physical parameters of the explosion using data from our programme of follow-up observations, finding that it produced a larger mass of radioactive nickel compared to other SNeIc-BL with similar inferred ejecta masses and kinetic energies. The progenitor of the event was likely a $\sim20$M$_{\odot}$ star.
description: Accepted for publication in MNRAS
The Gullible Person: development and validation of a self-report measure of gullibility
Creators: name: Teunisse, Alessa
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: People may have an enduring personality trait, gullibility, which makes them more likely to become scam victims. This dissertation describes the empirical development and validation of a new scale for measuring gullibility. After reviewing the relevant literature in Chapter 1, Chapter 2 reports on the development of a new, two-factor (Persuadability and Insensitivity), 12-item, Gullibility Scale. Chapter 3 presents two studies that confirm the two-factor structure of the Gullibility Scale, while also demonstrating that it is positively related to measures of paranormal beliefs and social vulnerability, negatively related to a measure of social intelligence, and not related to trust. Chapter 4 examines the scale’s test-retest reliability and criterion validity. The studies reported here showed that self-reported scam victims scored significantly higher on gullibility than did community members, psychology undergraduate students, and members of a critical thinking interest group (Skeptics). The remaining studies in this thesis examined the theoretical assertion that gullibility is a function of the ability and motivation to detect cues of untrustworthiness. Chapter 5 reports the results of two studies in which the Gullibility Scale was used to predict responses to a Prisoner’s Dilemma task that manipulated untrustworthiness cues. Although there was no relationship between scores on the Gullibility Scale and decisions made in the Prisoner’s Dilemma, the results provided confirmation that individual differences in trust and gullibility are unrelated. The final study in Chapter 6 presented participants with a series of scam emails. Gullibility was positively associated with rating scam emails as persuasive and also predicted intent to respond to them. However, there was no relationship between gullibility and cognitive ability (as measured by the Cognitive Reflection Test and Raven’s Advanced Progressive Matrices) or the ability to detect pseudo-profound bullshit. The final chapter, Chapter 7, reviews the findings of this dissertation and provides suggestions for future research.
Rescuing Quadratic Inflation
Creators: name: Ellis, John
name: Fairbairn, Malcolm
name: Sueiro, Maria
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Inflationary models based on a single scalar field $ϕ$ with a quadratic potential $V = \frac{1}{2} m^2 ϕ^2$ are disfavoured by the recent Planck constraints on the scalar index, $n_s$, and the tensor-to-scalar ratio for cosmological density perturbations, $r_T$. In this paper we study how such a quadratic inflationary model can be rescued by postulating additional fields with quadratic potentials, such as might occur in sneutrino models, which might serve as either curvatons or supplementary inflatons. Introducing a second scalar field reduces but does not remove the pressure on quadratic inflation, but we find a sample of three-field models that are highly compatible with the Planck data on $n_s$ and $r_T$. We exhibit a specific three-sneutrino example that is also compatible with the data on neutrino mass difference and mixing angles.
description: 17 pages, 12 figures