title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ð³Ð¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Bcl-2-Ð±ÐµÐ»ÐºÐ° Ð½Ð° Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸Ñ ÑÐ¸Ð½Ð°Ð¿ÑÐ¾Ð² Ð¸ ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ ÑÑÐ½ÐºÑÐ¸Ð¸ Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The effect of Bcl-2 protein overexpression on synapse morphology and cognitive functions in Alzheimers disease mouse model
Creators: name: ÐÐ¾ÑÐ´ÐµÐµÐ², ÐÐ½Ð´ÑÐµÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°
Bcl-2
5xFAD
Ð´ÐµÐ½Ð´ÑÐ¸ÑÐ½ÑÐµ ÑÐ¸Ð¿Ð¸ÐºÐ¸
ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²ÑÐ¹ ÑÐ¸Ð³Ð½Ð°Ð»Ð¸Ð½Ð³
Alzheimers disease
dendritic spines
calcium signaling

description: ÐÐ½ÑÐ¸Ð°Ð¿Ð¾Ð¿ÑÐ¾ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð±ÐµÐ»Ð¾Ðº Bcl-2 ÑÐ²Ð»ÑÐµÑÑÑ Ð²Ð½ÑÑÑÐ¸ÐºÐ»ÐµÑÐ¾ÑÐ½ÑÐ¼ ÑÐµÐ³ÑÐ»ÑÑÐ¾ÑÐ¾Ð¼ ÐºÐ°Ð»ÑÑÐ¸ÐµÐ²Ð¾Ð³Ð¾ ÑÐ¸Ð³Ð½Ð°Ð»Ð¸Ð½Ð³Ð°, Ð½Ð°ÑÑÑÐ°ÑÑÐµÐ³Ð¾ÑÑ Ð¿ÑÐ¸ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ° (ÐÐ). ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð³Ð¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ° Bcl-2 Ð² Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ñ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð° Ð½Ð° Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸Ñ Ð´ÐµÐ½Ð´ÑÐ¸ÑÐ½ÑÑ ÑÐ¸Ð¿Ð¸ÐºÐ¾Ð² Ð¸ Ð¿Ð°Ð¼ÑÑÑ ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ Ð² ÑÐµÑÑÐµ âÐ Ð°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ðµ Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐµÐºÑÐ°â Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ° 5xFAD . ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¾ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð±ÐµÐ»Ð¾Ðº Bcl-2 Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾ Ð²Ð»Ð¸ÑÐµÑ Ð½Ð° ÑÑÐ°Ð±Ð¸Ð»ÑÐ½Ð¾ÑÑÑ ÑÐ¸Ð½Ð°Ð¿ÑÐ¾Ð²: Ð²Ð¾ÑÑÑÐ°Ð½Ð°Ð²Ð»Ð¸Ð²Ð°ÐµÑ Ð¿ÑÐ¾ÑÐµÐ½ÑÐ½Ð¾Ðµ ÑÐ¾Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ðµ Ð³ÑÐ¸Ð±Ð¾Ð²Ð¸Ð´Ð½ÑÑ ÑÐ¸Ð¿Ð¸ÐºÐ¾Ð² Ð¸ ÑÐ½Ð¸Ð¶Ð°ÐµÑ Ð¿ÑÐ¾ÑÐµÐ½Ñ ÑÐ¾Ð½ÐºÐ¸Ñ Ð¸ Ð¿ÐµÐ½ÑÐºÐ¾Ð²ÑÑ ÑÐ¸Ð¿Ð¸ÐºÐ¾Ð². ÐÑÐ¾Ð¼Ðµ ÑÐ¾Ð³Ð¾, ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸, ÑÑÐ¾ Ð³Ð¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð±ÐµÐ»ÐºÐ° ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²ÑÐµÑ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð´ÐµÐºÐ»Ð°ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð¹ (Ð²Ð¼ÐµÑÑÐ¾ ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ñ) Ð¿Ð°Ð¼ÑÑÐ¸ Ñ Ð¼ÑÑÐµÐ¹ 5xFAD Ð² ÑÐµÑÑÐµ âÐ Ð°ÑÐ¿Ð¾Ð·Ð½Ð°Ð²Ð°Ð½Ð¸Ðµ Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐµÐºÑÐ°â: Ð½Ð¾Ð²ÑÐ¹ Ð¾Ð±ÑÐµÐºÑ Ð²ÑÐ·ÑÐ²Ð°Ð» Ð¸Ð½ÑÐµÑÐµÑ Ñ Ð¼ÑÑÐµÐ¹ ÑÐ°ÑÐµ, ÑÐµÐ¼ Ð·Ð½Ð°ÐºÐ¾Ð¼ÑÐ¹. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ Ð¿Ð¾Ð»Ð¾Ð¶Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ¾Ð»Ñ Bcl-2-Ð±ÐµÐ»ÐºÐ° Ð² ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² Ð¼ÑÑÐµÐ¹ Ð»Ð¸Ð½Ð¸Ð¸ 5xFAD, ÑÑÐ¾ Ð´ÐµÐ»Ð°ÐµÑ Bcl-2-Ð±ÐµÐ»Ð¾Ðº Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¼Ð¸ÑÐµÐ½ÑÑ Ð² Ð½ÐµÐ¹ÑÐ¾Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÑÑ, Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÑ Ð½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÑ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð² ÐÐ.
description: The anti-apoptotic protein Bcl-2 is an intracellular regulator of calcium signaling, impaired in Alzheimers disease neurons. This work is devoted to the study of the effect of Bcl-2 protein overexpression in hippocampal neurons on the morphology of dendritic spines and recognition memory in the âNovel object recognitionâ test in 5xFAD mice. According to the results of the study, it was found that the Bcl-2 protein has a positive effect on the synapses stability: it restores the percentage of mushroom spines and reduces the percentage of thin and stubby spines. In addition, the results of this work showed that overexpression of this protein contributes to the restoration of recognition memory in 5xFAD mice in the âNovel object recognitionâ test, since the mice noticed the appearance of a new object and were interested in it more often than familiar ones. The study shows the positive role of Bcl-2 protein in the functioning of 5xFAD mouse neurons, which constitutes Bcl-2 protein as a promising therapeutic target in neurobiological studies aimed at the developing of drug therapy against AD.