title: ÐÐÐ-Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ° Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ, Ð²ÑÐ·ÑÐ²Ð°ÑÑÐµÐ³Ð¾ Ð±ÑÐ°Ñ Ð¸ÑÐ¿Ð¸Ð½Ñ Ñ ÐºÑÑÐ¿Ð½Ð¾Ð³Ð¾ ÑÐ¾Ð³Ð°ÑÐ¾Ð³Ð¾ ÑÐºÐ¾ÑÐ°
title: Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ°ÑÐ·Ð°Ð½Ð¾Ð²Ð°, Ð¡.
name: ÐÐµÐ²ÑÐ¸ÑÐ¾Ð², Ð.
name: Ð¢ÑÑÐ±Ð¸Ð½Ð°, Ð.
name: ÐÐ°ÑÐ·Ð°Ð½Ð¾Ð², Ð.
Publisher: name: ÐÐºÐ°Ð´ÐµÐ¼Ð¸Ñ ÐÑÐ¸Ð½Ñ
Year: 2024
Subjects: ÐºÑÑÐ¿Ð½ÑÐ¹ ÑÐ¾Ð³Ð°ÑÑÐ¹ ÑÐºÐ¾Ñ
Ð³Ð¾Ð»ÑÑÐ¸Ð½ÑÐºÐ¸Ð¹ ÑÐºÐ¾Ñ
Ð¶Ð¸Ð²Ð¾ÑÐ½Ð¾Ð²Ð¾Ð´ÑÑÐ²Ð¾

description: Ð Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð´Ð°Ð½ Ð¾Ð±Ð·Ð¾Ñ Ð¿Ð¾ ÐÐÐ-Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ, Ð²ÑÐ·ÑÐ²Ð°ÑÑÐµÐ³Ð¾ Ð±ÑÐ°ÑÐ¸ÑÐ¿Ð¸Ð½Ñ Ñ Ð³Ð¾Ð»ÑÑÐ¸Ð½ÑÐºÐ¾Ð¹ Ð¿Ð¾ÑÐ¾Ð´Ñ Ð¸ ÐµÐµ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÑ Ð¿Ð¾Ð¼ÐµÑÐµÐ¹. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð°Ñ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÐÐ¦Ð -Ð Ð. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð° Ð³ÐµÐ½Ð¾Ð³ÐµÐ¾Ð³ÑÐ°ÑÐ¸Ñ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ð² Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ð¸ Ð¸ Ð·Ð° ÑÑÐ±ÐµÐ¶Ð¾Ð¼. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ð¿Ð¾ ÑÐ°ÐºÐ¸Ð¼ ÑÐ²Ð»ÐµÐ½Ð¸ÑÐ¼, ÐºÐ°Ðº Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ°Ñ Ð³ÐµÐ½ÐµÐ°Ð»Ð¾Ð³Ð¸Ñ, ÑÑÑÐµÐºÑ Ð¾ÑÐ½Ð¾Ð²Ð°ÑÐµÐ»Ñ, Ð´ÑÐµÐ¹Ñ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ. ÐÑÐ¸ÑÐµÐ¼ Ð´ÑÐµÐ¹Ñ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ ÐºÐ°Ðº Ð²Ð½ÑÑÑÐ¸, ÑÐ°Ðº Ð¸ Ð¼ÐµÐ¶Ð´Ñ ÑÑÑÐ°Ð½Ð°Ð¼Ð¸ Ð¾Ð±ÑÑÐ»Ð¾Ð²Ð»ÐµÐ½ Ð½Ðµ ÐµÑÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐ¼, Ð° Ð¸ÑÐºÑÑÑÑÐ²ÐµÐ½Ð½ÑÐ¼ Ð¾ÑÐ±Ð¾ÑÐ¾Ð¼. ÐÑÐ¸ÑÐ¸Ð½Ð¾Ð¹ ÑÐ²Ð»ÑÐµÑÑÑ Ð¶ÐµÑÑÐºÐ°Ñ ÑÐµÐ»ÐµÐºÑÐ¸Ñ Ð¸ ÑÐ¸ÑÐ¾ÐºÐ¾Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ»Ð¸ÑÐ½ÑÑ Ð±ÑÐºÐ¾Ð², Ð¸ÑÐºÑÑÑÑÐ²ÐµÐ½Ð½Ð¾Ðµ Ð¾ÑÐµÐ¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð±Ð¾Ð»ÑÑÐ¾Ð³Ð¾ Ð¼Ð°ÑÑÐ¸Ð²Ð° ÐºÐ¾ÑÐ¾Ð², Ð¼Ð½Ð¾Ð¶ÐµÑÑÐ²ÐµÐ½Ð½Ð°Ñ Ð¾Ð²ÑÐ»ÑÑÐ¸Ñ Ð¸ ÑÐ¼Ð±ÑÐ¸Ð¾ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ñ (ÐÐÐ­Ð¢). ÐÑÐµ ÑÑÐ¾ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð³Ð¾Ð²Ð¾ÑÐ¸ÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ Ð¼Ñ Ð¸Ð¼ÐµÐµÐ¼ Ð´ÐµÐ»Ð¾ ÐµÑÐµ Ñ Ð¾Ð´Ð½Ð¾Ð¹ Ð¿Ð¾ÑÐ¾Ð´Ð¾ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¼ÑÑÐ°ÑÐ¸ÐµÐ¹ Ñ Ð³Ð¾Ð»ÑÑÐ¸Ð½Ð¾Ð². ÐÐ·ÑÑÐµÐ½Ð¾ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸Ðµ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ Ð°Ð»Ð»ÐµÐ»Ñ ÑÑÐµÐ´Ð¸ Ð±ÑÐºÐ¾Ð²-Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð¸ÑÐµÐ»ÐµÐ¹ Ð³Ð¾Ð»ÑÑÐ¸Ð½ÑÐºÐ¾Ð¹ Ð¿Ð¾ÑÐ¾Ð´Ñ Ð¸ ÐµÐ³Ð¾ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÑ Ð¿Ð¾Ð¼ÐµÑÐµÐ¹ Ð² Ð Ð¾ÑÑÐ¸Ð¸ Ð¸ Ð¼Ð¸ÑÐµ. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ñ Ð±ÑÐºÐ¸-Ð½Ð¾ÑÐ¸ÑÐµÐ»Ð¸ Ð¸ Ð¿ÑÑÐ¸ Ð¿ÑÐ¾Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ð±ÑÐ°ÑÐ¸ÑÐ¿Ð¸Ð½Ñ Ð² Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÑÑ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ñ. ÐÐ°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÐ°ÑÑÐ¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ð²ÑÑÑÐµÑÐ°ÐµÑÑÑ Ð² ÑÐ°Ð·Ð²Ð¸ÑÑÑ ÑÑÑÐ°Ð½Ð°Ñ Ð¿Ð¾ Ð¼Ð¾Ð»Ð¾ÑÐ½Ð¾Ð¼Ñ ÑÐºÐ¾ÑÐ¾Ð²Ð¾Ð´ÑÑÐ²Ñ. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½ ÑÐ°Ð¼, Ð³Ð´Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ Ð±ÑÐºÐ¸-Ð½Ð¾ÑÐ¸ÑÐµÐ»Ð¸. ÐÐ¾ÑÐ¾Ð²Ñ ÑÐ»ÑÐ¶Ð°Ñ ÑÐµÐ·ÐµÑÐ²Ð°ÑÐ¾Ð¼, ÑÐ¾ÑÑÐ°Ð½ÑÑÑÐ¸Ð¼ Ð¼ÑÑÐ°Ð½ÑÐ½ÑÐ¹ Ð°Ð»Ð»ÐµÐ»Ñ ÐºÐ°Ðº Ð¼ÐµÐ½Ð´ÐµÐ»Ð¸ÑÑÑÑÐ¸Ð¹ Ð¿ÑÐ¸Ð·Ð½Ð°Ðº Ð² Ð¿Ð¾Ð¿ÑÐ»ÑÑÐ¸Ð¸. ÐÐ¾Ð´Ð¾Ð±Ð½Ð¾Ðµ ÑÐ°Ð½ÐµÐµ Ð±ÑÐ»Ð¾ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾ Ð¿Ð¾ CD18G Ð¸ SLC35A3T Ð°Ð»Ð»ÐµÐ»ÑÐ¼ Ñ Ð³Ð¾Ð»ÑÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾ Ð¸ Ð³Ð¾Ð»ÑÑÐ¸Ð½Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÐºÑÑÐ¿Ð½Ð¾Ð³Ð¾ ÑÐ¾Ð³Ð°ÑÐ¾Ð³Ð¾ ÑÐºÐ¾ÑÐ°. Ð£ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ð²ÑÑÑÐµÑÐ°ÐµÑÑÑ Ð² ÑÑÐ´Ðµ Ð¸Ð·Ð²ÐµÑÑÐ½ÑÑ Ð»Ð¸Ð½Ð¸Ð¹ Ð¸ Ð¸Ñ Ð²ÐµÑÐ²ÐµÐ¹ Ð³Ð¾Ð»ÑÑÐ¸Ð½ÑÐºÐ¾Ð¹ Ð¿Ð¾ÑÐ¾Ð´Ñ (Ð£ÐµÑ ÐÐ´ÐµÐ°Ð»Ð° 933122 Ð¸ ÐµÐ³Ð¾ Ð²ÐµÑÐ²ÐµÐ¹ Ð­Ð»ÐµÐ²ÐµÐ¹ÑÐ½Ð° 1491007 Ð¸ Ð¡ÑÐ°ÑÐ±ÑÐºÐ° 352790; Ð ÐµÑÐ»ÐµÐºÑÐ½ Ð¡Ð¾Ð²ÐµÑÐ¸Ð½Ð³Ð° 252803 Ð¸ ÐµÐ³Ð¾ Ð²ÐµÑÐ²Ð¸ Ð.Ð¤.Ð. Ð§Ð¸ÑÐ° 1427381; ÐÐ¾Ð½ÑÐ²Ð¸ÐºÐ° Ð§Ð¸ÑÑÐµÐ¹Ð½Ð° 95679). ÐÑÐ¸ÑÐµÐ¼ Ð»Ð¸Ð´ÐµÑÐ¾Ð¼ ÑÑÐµÐ´Ð¸ Ð½Ð¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð»Ð¸Ð½Ð¸Ñ ÐÐ¾Ð½ÑÐ²Ð¸ÐºÐ° Ð§Ð¸ÑÑÐµÐ¹Ð½Ð° 95679, ÑÐµÑÐµÐ· ÐºÐ¾ÑÐ¾ÑÑÑ Ð½Ð°Ð¸Ð±Ð¾Ð»ÑÑÐ¸Ð¼ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾Ð¼ Ð¿Ð¾ÑÐ¾Ð¼ÐºÐ¾Ð² ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½Ð¸Ð»Ð¸ÑÑ CD18G, SLC35A3T, Ð° ÑÐµÐ¿ÐµÑÑ Ð¸ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ð¿Ð¾ Ð²ÑÐµÐ¼Ñ Ð¼Ð¸ÑÑ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹ Ð¿Ð¾ Ð»Ð¸ÐºÐ²Ð¸Ð´Ð°ÑÐ¸Ð¸ Ð¼ÑÑÐ°Ð½ÑÐ½Ð¾Ð³Ð¾ FANCIBY Ð°Ð»Ð»ÐµÐ»Ñ Ð±ÑÐ°ÑÐ¸ÑÐ¿Ð¸Ð½Ñ Ð² Ð¿Ð»ÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÑÐ°Ð´Ð°Ñ Ð Ð¾ÑÑÐ¸Ð¸. ÐÐ¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ Ð³ÐµÐ½ÐµÑÐ¸ÐºÐ¾Ð², Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°ÑÐµÐ»ÐµÐ¹ Ð¸ Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ¾Ð² Ð²ÑÐ·Ð¾Ð² Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ ÑÐµÐ»ÑÑÐºÐ¾ÑÐ¾Ð·ÑÐ¹ÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð»Ñ, ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð² Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¶Ð¸Ð²Ð¾ÑÐ½Ð¾Ð²Ð¾Ð´ÑÑÐ²Ð°, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ»ÑÑÐ°ÑÐµÐ»ÐµÐ¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð°Ð³ÑÐ°ÑÐ½Ð¾Ð³Ð¾ Ð´Ð¾Ð¿Ð¾Ð»Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ.
description: This monograph provides an overview of the DNA diagnosis of the mutant FANCIBY allele causing brachyspina in the Holstein breed and its numerous littermates. The developed method for diagnosing the FANCIBY allele using RT-PCR is presented. The
genogeography of the FANCIBY allele in the Russian Federation and abroad is shown. Based on the results obtained, materials on such phenomena as genetic genealogy, founder effect, and drift of the mutant FANCIBY allele are shown. Moreover, the drift of the mutant FANCIBY allele both within and between countries is caused not by natural, but by artificial selection. The reason is strict selection and widespread use of elite bulls, artificial insemination of a large number of cows, multiple ovulation and embryo transplantation (MOET). All this allows us to say that we are dealing with another breed-specific mutation in Holsteins. The distribution of the mutant allele among bulls of the Holstein breed and its numerous crosses in Russia and the world was studied. The carrier bulls and the routes of penetration of the mutant FANCIBY allele of brachispin into the Russian Federation are shown. It has been established that the FANCIBY allele is found most often in developed dairy farming countries. It has been proven that the FANCIBY allele is common where carrier bulls were used. Cows serve as a reserve, preserving the mutant allele as a Mendelian trait in the population. Similar findings were previously found for the CD18G and SLC35A3T alleles in Holstein and Holsteinized cattle. It was established that the FANCIBY allele is found in a number of famous lines and their branches of the Holstein breed (Ues Ideal 933122 and its branches Eleveishn 1491007 and Starbuk 352790; Reflection Sovering 252803 and its P.F.A. Chifâs branches 95679). Moreover, the leader among them is the Montvik Chieftain line 95679, through which the largest number of descendants spread the CD18G, SLC35A3T, and now the FANCIBY allele throughout the world. A set of measures has been developed to eliminate the mutant FANCIBY allele of brachispina in Russian breeding herds. The monograph is intended for geneticists, teachers and graduate students of biological and agricultural universities, specialists in the field of animal husbandry, as well as students of the system of agricultural additional professional education.