title: ÐÑÐµÐ½ÐºÐ° Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑÐ¾Ð² Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ Ð¿Ð¾ÑÐµÐº Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸ÑÐ¼Ð¸ Ð´ÑÑ Ð°ÑÐµÐ»ÑÐ½ÑÑ Ð¿ÑÑÐµÐ¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Assessment of the informative value of biomarkers of chronic kidney disease in patients with chronic respiratory diseases
Creators: name: ÐÑÐ°ÑÐ¾Ð²Ð°, ÐÐ»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ñ Ð¿Ð¾ÑÐµÐº
Ð±ÑÐ¾Ð½Ñ Ð¸Ð°Ð»ÑÐ½Ð°Ñ Ð°ÑÑÐ¼Ð°
Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ð¾Ð±ÑÑÑÑÐºÑÐ¸Ð²Ð½Ð°Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ñ Ð»ÐµÐ³ÐºÐ¸Ñ
Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½ÑÐµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ
Ð¼Ð°ÑÐºÐµÑÑ Ð¿Ð¾Ð²ÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÐµÐº
cystatin c
vegf a
chronic kidney disease
bronchial asthma
chronic obstructive pulmonary disease
chronic respiratory diseases
markers of kidney damage

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² ÑÐ°Ð½Ð½ÐµÐ¹ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµ Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑÐ¾Ð² ÑÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ Ð¿Ð¾ÑÐµÐº Ð¿ÑÐ¸ ÑÐ¾Ð²Ð¼ÐµÑÑÐ½Ð¾Ð¹ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¿Ð¾ÑÐµÐº Ð¸ Ð´ÑÑÐ°ÑÐµÐ»ÑÐ½ÑÑ Ð¿ÑÑÐµÐ¹. ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: 1. ÐÑÑÑÐµÑÑÐ²Ð¸ÑÑ Ð¿ÑÐ¾Ð±Ð¾Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÑ Ð¾Ð±ÑÐ°Ð·ÑÐ¾Ð² Ð¼Ð¾ÑÐ¸ Ð¸ ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐ¸ ÐºÑÐ¾Ð²Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÑÐ¾Ð²Ð¼ÐµÑÑÐ½Ð¾Ð¹ Ð¿Ð°ÑÐ¾Ð»Ð¾Ð³Ð¸ÐµÐ¹ Ð»ÐµÐ³ÐºÐ¸Ñ Ð¸ Ð¿Ð¾ÑÐµÐº Ð¸ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ. 2. ÐÑÐµÐ½Ð¸ÑÑ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ðµ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ Ð¿Ð¾ÑÐµÐº Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÑÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸ÑÐ¼Ð¸ Ð´ÑÑÐ°ÑÐµÐ»ÑÐ½ÑÑ Ð¿ÑÑÐµÐ¹ Ð¿Ð¾ÑÑÐµÐ´ÑÑÐ²Ð¾Ð¼ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ ÑÑÐ´Ð° Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑÐ¾Ð² Ð² Ð¾Ð±ÑÐ°Ð·ÑÐ°Ñ ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐ¸ ÐºÑÐ¾Ð²Ð¸ Ð¸ Ð¼Ð¾ÑÐ¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð². 3. ÐÑÐ¾Ð²ÐµÑÑÐ¸ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ Ð´Ð°Ð½Ð½ÑÑ. 4. ÐÐ¿ÑÐµÐ´ÐµÐ»Ð¸ÑÑ ÑÐ°ÐºÑÐ¾ÑÑ, Ð°ÑÑÐ¾ÑÐ¸Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ñ Ð¥ÐÐ Ñ Ð±Ð¾Ð»ÑÐ½ÑÑ Ð°ÑÑÐ¼Ð¾Ð¹. Ð Ð°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð² ÐÐ°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð³Ð¾Ð¼ÐµÐ¾ÑÑÐ°Ð·Ð° ÐÐÐ ÐÐµÑÑÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¤ÐÐÐÐ£ ÐÐ ÐÐ¡ÐÐ±ÐÐÐ£ Ð¸Ð¼. Ð°Ðº. Ð.Ð. ÐÐ°Ð²Ð»Ð¾Ð²Ð° ÐÐ¸Ð½Ð·Ð´ÑÐ°Ð²Ð° Ð Ð¾ÑÑÐ¸Ð¸. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð´Ð¾Ð±ÑÐµÐ½Ð¾ Ð»Ð¾ÐºÐ°Ð»ÑÐ½ÑÐ¼ ÑÑÐ¸ÑÐµÑÐºÐ¸Ð¼ ÐºÐ¾Ð¼Ð¸ÑÐµÑÐ¾Ð¼ ÐÐ¡ÐÐ±ÐÐÐ£. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¿ÑÐ¾Ð´ÐµÐ»Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð²ÑÑÐ²Ð»ÐµÐ½Ñ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÐµ Ð±Ð¸Ð¾Ð¼Ð°ÑÐºÐµÑÑ Ð¥ÐÐ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð±ÑÐ¾Ð½ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð¹ Ð°ÑÑÐ¼Ð¾Ð¹ (ÐÐ). ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ð³Ð¾ ROC-Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½ÑÐ¼ Ð¼Ð°ÑÐºÐµÑÐ¾Ð¼ Ð¿Ð¾Ð²ÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÐµÐº Ñ Ð±Ð¾Ð»ÑÐ½ÑÑ ÐÐ Ð¼Ð¾Ð¶Ð½Ð¾ Ð²ÑÐ´ÐµÐ»Ð¸ÑÑ ÑÐ¸ÑÑÐ°ÑÐ¸Ð½ Ð¡ ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐ¸ ÐºÑÐ¾Ð²Ð¸.
description: This study considers the possibility of using the biomarkers in the early diagnosis of chronic kidney disease (CKD) with the joint pathology of renal and respiratory tract. The research set the following goals: 1. Carry out sample preparation of urine and blood serum samples from patients with joint pathology of the lungs and kidneys and the control group. 2. To assess the functional state of the kidneys of patients with chronic respiratory diseases by measuring the urine and serum concentration of several biomarkers. 3. Conduct statistical analysis of data. 4. Determine the factors associated with CKD in patients with asthma. The work was carried out in the Laboratory of biochemical homeostasis of the Research Institute of Nephrology of Pavlov First St.Petersburg State Medical University. The research was approved by the local ethics Committee of SPbGMU. As a result of the work, promising biomarkers of CKD were identified in patients with bronchial asthma (BA). According to the results of the ROC analysis, serum cystatin C can be considered the most informative marker of kidney damage in BA patients.