cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IgG4H – mitme näoga immuunhaigus
Creators: name: Tulk, Maris
name: Uibo, Raivo
name: Kuuse, Reet
Publisher: name: Eesti Arst
Year: 2023

description: Immuunglobuliin G4 haigus ehk IgG4-haigus (IgG4H) on süsteemne fibroospõletikuline haigusseisund, mis võib haarata peaaegu kõiki elundeid. Haigusele on iseloomulik salakaval algus, järkjärguline progressioon ning kroonilisus. Iseloomulikeks tunnusteks on immuunglobuliin G4 (IgG4) kõrge tase seerumis, tuumorisarnased (tumefactive) kolded piltdiagnostikal, keerisekujuline fibroos (storiform fibrosis), oblitereeriv flebiit ja polükloonsete IgG4-positiivsete rakkude rikkad lümfoplasmaatilised infiltraadid – kas ühes elundis või erinevates elundites samal ajal. Sagedamini on haaratud pankreas, hepatobiliaarne süsteem, silmad, süljenäärmed ja pisaranäärmed koos pisarakanaliga. Haigus on progresseeruva iseloomuga, teisi infiltratiivseid haigusi jäljendav ning seetõttu võib diagnoos hilineda. Suurem teadlikkus haiguse olemusest tagab õige diagnoosi varasemas faasis, mil saab veel ennetada fibroosi teket, seega rasket elundikahjustust.
description: Eesti Arst, 2023: Jaanuar
Ubiquitin editing enzyme UCH L1 and microtubule dynamics: Implication in mitosis
Creators: name: Pagano, Joseph S.
name: Caplow, Michael
name: Gullapalli, Anuradha
name: Shackelford, Julia
name: Bheda, Anjali
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Microtubules are essential components of the cytoskeleton and are involved in many aspects of cell responses including cell division, migration, and intracellular signal transduction. Among other factors, post-translational modifications play a significant role in the regulation of microtubule dynamics. Here, we demonstrate that the ubiquitin-editing enzyme UCH L1, abundant expression of which is normally restricted to brain tissue, is also a part of the microtubule network in a variety of transformed cells. Moreover, during mitosis, endogenous UCH L1 is expressed and tightly associated with the mitotic spindle through all stages of M phase, suggesting that UCH L1 is involved in regulation of microtubule dynamics. Indeed, addition of recombinant UCH L1 to the reaction of tubulin polymerization in vitro had an inhibitory effect on microtubule formation. Unexpectedly, western blot analysis of tubulin fractions after polymerization revealed the presence of a specific ∼50 kDa band of UCH L1 (not the normal ∼25 kDa) in association with microtubules, but not with free tubulin. In addition, we show that along with 25 kDa UCH L1, endogenous high molecular weight UCH L1 complexes exist in cells, and that levels of 50 kDa UCH L1 complexes are increasing in cells during mitosis. Finally, we provide evidence that ubiquitination is involved in tubulin polymerization: the presence of ubiquitin during polymerization in vitro by itself inhibited microtubule formation and enhanced the inhibitory effect of added UCH L1. the inhibitory effects of UCH L1 correlate with an increase in ubiquitination of microtubule components. Since besides being a deubiquitinating enzyme, UCH L1 as a dimer has also been shown to exhibit ubiquitin ligase activity, we discuss the possibility that the ∼50 kDa UCH L1 observed is a dimer which prevents microtubule formation through ubiquitination of tubulins and/or microtubule-associated proteins.
title: Ovarian lesions with T2 hypointensity: What radiologists need to know
Creators: name: Sahin, Hilal
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Genital / Reproductive system female
subject: MR
subject: Contrast agent-intravenous
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the T2 hypointense ovarian lesions and their typical imaging characteristics. To show the challenging imaging findings of T2 hypointense ovarian lesions and discuss the differential diagnosis on MRI based...
(401674) John Burnet
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Characterization of functional domains in human Claspin
Creators: name: Kemp, Michael G.
name: Serçin, Özdemirhan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Claspin is a mediator of the ATR-dependent DNA replication checkpoint in human cells and also promotes DNA replication fork progression and stability. Though Claspin has been shown to bind DNA and co-immunoprecipitate with other replication fork-associated proteins, the specific protein-protein and protein-DNA interactions that are important for Claspin function are not known. We therefore purified several domains of human Claspin and then tested for direct interactions of these fragments with several replication fork-associated proteins and with DNA. Our data show that the N terminus of Claspin binds to the replicative helicase co-factor Cdc45, the Timeless protein and a branched, replication fork-like DNA structure. In contrast, the C terminus of Claspin associates with DNA polymerase epsilon and Rad17-Replication Factor C (RFC). We conclude that multiple protein-DNA and protein-protein interactions may be important for Claspin function during DNA replication and DNA replication checkpoint signaling.
Damage-induced localized hypermutability
Creators: name: Resnick, Michael A.
name: Mieczkowski, Piotr A.
name: Chao, Frank G.
name: Yang, Yong
name: Zhang, Leilei
name: Burch, Lauranell H.
name: Gordenin, Dmitry A.
name: Roberts, Steven A.
name: Sterling, Joan F.
name: Walsh, Jesse
name: Xu, Hong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Genome instability continuously presents perils of cancer, genetic disease and death of a cell or an organism. At the same time, it provides for genome plasticity that is essential for development and evolution. We address here the genome instability confined to a small fraction of DNA adjacent to free DNA ends at uncapped telomeres and double-strand breaks. We found that budding yeast cells can tolerate nearly 20 kilobase regions of subtelomeric single-strand DNA that contain multiple UV-damaged nucleotides. During restoration to the double-strand state, multiple mutations are generated by error-prone translesion synthesis. Genome-wide sequencing demonstrated that multiple regions of damage-induced localized hypermutability can be tolerated, which leads to the simultaneous appearance of multiple mutation clusters in the genomes of UV-irradiated cells. High multiplicity and density of mutations suggest that this novel form of genome instability may play significant roles in generating new alleles for evolutionary selection as well as in the incidence of cancer and genetic disease.
Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition
Creators: name: Vaziri, Cyrus
name: Palle, Komaraiah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Camptothecin (CPT) and related chemotherapeutic drugs induce formation of DNA topoisomerase I (Top1) covalent or cleavage complexes (Top1ccs) that block leading-strand DNA synthesis and elicit DNA Double Stranded Breaks (DSB) during S phase. The Fanconi Anemia (FA) pathway is implicated in tolerance of CPT-induced DNA damage yet the mechanism of FA pathway activation by Top1 poisons has not been studied. We show here that the FA core complex protein FANCA and monoubiquitinated FANCD2 (an effector of the FA pathway) are rapidly mobilized to chromatin in response to CPT treatment in several human cancer cell lines and untransformed primary human dermal fibroblasts. FANCD2 depletion using siRNA leads to impaired recovery from CPT-induced inhibition or DNA synthesis, persistence of γH2AX (a DSB marker) and reduced cell survival following CPT treatment. The E3 ubiquitin ligase Rad18 is necessary for CPT-induced recruitment of FANCA and FANCD2 to chromatin. Moreover, Rad18-depletion recapitulates the DNA synthesis and survival defects of FANCD2-deficiency in CPT-treated cells. It is well-established that Rad18 promotes FA pathway activation and DNA damage tolerance in response to bulky DNA lesions via a mechanism involving PCNA monoubiquitination. In contrast, PCNA monoubiquitination is not involved in Rad18-mediated FA pathway activation or cell survival following acquisition of CPT-induced DSB. Moreover, while Rad18 is implicated in recombinational repair of DSB via an E3 ligase-independent mechanism, we demonstrate that Rad18 E3 ligase activity is essential for appropriate FA pathway activation and DNA damage tolerance after CPT treatment. Taken together, our results define a novel pathway of Rad18-dependent DSB repair that is dissociable from known Rad18-mediated DNA repair mechanisms based on its independence from PCNA ubiquitination and requirement for E3 ligase activity.
Tet1 and 5-hydroxymethylation: A genome-wide view in mouse embryonic stem cells
Creators: name: Zhang, Yi
name: Wu, Hao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Inner cell mass (ICM) cells of a blastocyst, the source of embryonic stem (ES) cells, are characterized by their unique ability to give rise to all cell types in adult organisms. The epigenomes of germ cells and developing zygotes undergo extensive reprogramming to acquire such a pluripotent state. A major reprogramming event during early embryonic development is the erasure and subsequent re-establishment of patterns of methylation at the 5-position of cytosine (5mC). The recent demonstration that Ten-eleven translocation family proteins, Tet1-3 have the capacity to convert 5mC to 5-hydroxymethylcytosine (5hmC) raises the possibility that 5hmC may act as an distinct epigenetic state contributing to dynamic changes in DNA methylation and transcriptional regulation during embryonic development. In ES cells, Tet1 is highly expressed and 5hmC is present at relatively high levels compared to most differentiated cells, but the functional significance of Tet1 and 5hmC in these pluripotent cells are not clear. Recently, a flurry of papers that profile the distribution of Tet1 and/or 5hmC across the genome of mouse ES cells provide new insights into the role of Tet proteins and 5hmC in regulating expression of genes related to pluripotency and cellular differentiation. Through integrative analyses of datasets from different groups, we reveal the common Tet1 and 5hmC targets in undifferentiated mouse ES cells, which suggest that Tet1 may play a key role in orchestrating the balance between pluripotent and lineage committed states.
Epileptiliste hoogude ja epilepsia käsitlus insuldi järel
Creators: name: Nõmmik, Britta-Mai
name: Kõrv, Janika
name: Rakitin, Aleksei
Publisher: name: Eesti Arst
Year: 2023

description: Insuldi järel tekkinud epileptilised hood on sage insuldi tüsistus. Kuna rahvastik vananeb ja vanus on sõltumatu insuldi riskitegur, suureneb tõenäoliselt insuldijärgsete epileptiliste hoogude ja epilepsia esinemissagedus. Nii epilepsia diagnoosimise kui ka ravi seisukohalt on oluline eristada ägedaid sümptomaatilisi ehk ägedast protsessist provotseeritud ja hiliseid sümptomaatilisi ehk provotseerimata hooge. Epilepsiat saab diagnoosida pärast esimest provotseerimata hoogu, kui kordumise risk on üle 60% järgneva 10 aasta jooksul. Uuringud on näidanud, et insuldijärgse esimese nädala jooksul tekkinud epileptilised hood on seotud korduvate epileptiliste hoogude 33% tekkeriskiga järgneva 10 aasta jooksul, samas pärast 7. insuldijärgset päeva tekkinud (hiline) hoog suurendab korduvate epileptiliste hoogude tekkeriski 72%. Seega tuleb ühe hilise epileptilise hoo esinemisel kaaluda insuldijärgse epilepsia diagnoosimist ja ravi alustamist. Samas ei ole epilepsia ravi alustamine näidustatud ägedate sümptomaatiliste hoogude korral. Artiklis on antud ülevaade insuldijärgsete epileptiliste hoogude epidemioloogiast, patogeneesist, riskiteguritest, diagnoosimisest ja ravist. Praegustele teadmistele ja tõenduspõhistele ravijuhenditele toetudes on käsitletud kliinilises praktikas esinevaid probleeme, seda, millal insuldijärgset epilepsiat diagnoosida, milline on optimaalne aeg alustada ravi ning milline epilepsiaravim valida.
description: Eesti Arst, 2023: Jaanuar
Differences in the quasiparticle dynamics for one-band and three-band cuprate models
Creators: name: Ebrahimnejad, Hadi
name: Sawatzky, George A.
name: Berciu, Mona
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the quasiparticles of the one-band $t$-$J$ and $t$-$t'$-$t"$-$J$ models using a variational approximation that includes spin fluctuations in the vicinity of the hole. We explain why the spin fluctuations and the longer range hopping have complementary contributions to the quasiparticle dynamics, and thus why both are essential to obtain a dispersion in agreement with that measured experimentally. This is very different from the three-band Emery model in the strongly-correlated limit, where the same variational approximation shows that spin fluctuations have a minor effect on the quasiparticle dynamics. This difference proves that these one-band and three-band models describe qualitatively different quasiparticles, and therefore they they cannot both be suitable to describe the physics of underdoped cuprates.
description: 14 pages, 7 figures
title: Evaluation of different computer vision algorithms for an automated identification of unknown individuals
Creators: name: Heinrich, Andreas
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: Digital radiography
subject: Computer Applications-Detection, diagnosis
subject: Physics
subject: Technology assessment
subject: Forensics
subject: Quality assurance

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Identifying unknown individuals by comparing a post-mortem dental panoramic radiograph (DPR) to an ante-mortem DPR database using computer vision methods is a promising new approach [1; 2] and can be performed to support the Virtopsy [3-6]. Unique...
Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts
Creators: name: Ibrahim, Joseph G.
name: Kaufmann, William K.
name: Cordeiro-Stone, Marila
name: Zhou, Ying Chun
name: Simpson, Dennis A.
name: Patel, Shivani S.
name: Kaiser-Rogers, Kathleen A.
name: Rao, Shangbang
name: Smith-Roe, Stephanie L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The Timeless-Tipin complex and Claspin are mediators of the ATR-dependent activation of Chk1 in the intra-S checkpoint response to stalled DNA replication forks. Tim-Tipin and Claspin also contribute to sister chromatid cohesion (SCC) in various organisms, likely through a replication-coupled process. Some models of the establishment of SCC posit that interactions between cohesin rings and replisomes could result in physiological replication stress requiring fork stabilization. The contributions of Timeless, Tipin, Claspin, Chk1 and ATR to SCC were investigated in genetically stable, human diploid fibroblast cell lines. Whereas Timeless, Tipin and Claspin showed similar contributions to UVC-induced activation of Chk1, siRNA-mediated knockdown of Timeless induced a 100-fold increase in sister chromatid discohesion, whereas the inductive effects of knocking down Tipin, Claspin and ATR were 4–20-fold. Knockdown of Chk1 did not significantly affect SCC. Consistent findings were obtained in two independently derived human diploid fibroblast lines and support a conclusion that SCC in human cells is strongly dependent on Timeless but independent of Chk1. Furthermore, the 10-fold difference in discohesion observed when depleting Timeless versus Tipin indicates that Timeless has a function in SCC that is independent of the Tim-Tipin complex, even though the abundance of Timeless is reduced when Tipin is targeted for depletion. A better understanding of how Timeless, Tipin and Claspin promote SCC will elucidate non-checkpoint functions of these proteins at DNA replication forks and inform models of the establishment of SCC.
title: Spit it out! A pictorial review of salivary glands pathology.
Creators: name: Cokkinos, Demosthenes
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: Salivary glands
subject: CT
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Infection
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To exhibit the most typical pathologic conditions of the salivary glands and the critical sonographic features that the radiologist should recognise and evaluate. To submit illustrative cases where ultrasound (US) is used for optimal recognition and...
Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer
Creators: name: Johnson, Gary L.
name: Abell, Amy N.
name: Jordan, Nicole Vincent
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Epithelial-mesenchymal transition (EMT) is an essential developmental program that becomes reactivated in adult tissues to promote the progression of cancer. EMT has been largely studied by examining the beginning epithelial state or the ending mesenchymal state without studying the intermediate stages. Recent studies using trophoblast stem (TS) cells paused in EMT have defined the molecular and epigenetic mechanisms responsible for modulating the intermediate “metastable” stages of EMT. Targeted inactivation of MAP3K4, knockdown of CBP or overexpression of SNAI1 in TS cells induced similar metastable phenotypes. These TS cells exhibited epigenetic changes in the histone acetylation landscape that cause loss of epithelial maintenance while preserving self-renewal and multipotency. A similar phenotype was found in claudin-low breast cancer cells with properties of EMT and stemness. This intersection between EMT and stemness in TS cells and claudin-low metastatic breast cancer demonstrates the usefulness of developmental EMT systems to understand EMT in cancer.
title: Why you should add Contrast for emergency Ultrasound of the testicles.
Creators: name: Cokkinos, Demosthenes
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Contrast agents
subject: Ultrasound
subject: Contrast agent-intravenous
subject: Abscess
subject: Infection
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To explain the advantages of using Contrast Enhanced Ultrasound (CEUS) for emergency imaging of the testicles. To review indications, imaging findings, limitations and pitfalls of this practice. To present the added value of CEUS by showing how it...
Silmamaterjalidest isoleeritud mikroobide ja viiruste spekter ning ravimitundlikkus Tartu Ülikooli Kliinikumi silmakliinikus 2017 kuni 2021
Creators: name: Lõivukene, Krista
name: Kermes, Kadri
name: Randoja, Raili
name: Kõljalg, Siiri
name: Kaljurand, Kuldar
Publisher: name: Eesti Arst
Year: 2023

description: Eesmärk. Uuringu eesmärk oli kindlaks teha silmamaterjalidest isoleeritud mikroobide spekter, hinnata bakterite antibiootikumitundlikkust ja võrrelda seda kasutatavate paiksete ravimite valikuga. Materjal ja meetodid. Analüüsiti aastatel 2017–2021 TÜ Kliinikumi silmakliinikust ühendlaborisse saadetud silmamaterjalidest tehtud külvide ja viiruste tuvastamise tulemusi. Bakterid ja seened samastati MALDI-TOFi seadmega. Antibiootikumitundlikkus määrati Kirby-Baueri diskdifusioonmeetodil ja hinnati EUCASTi kriteeriumite alusel. Viirused tuvastati reaalaja polümeraasahelreaktsiooni (PCR) meetodil. Andmed saadi eLabori statistikaprorammist OLAP (analüüside arv, tekitajate spekter, antibiootikumitundlikkus). Paiksete ravimpreparaatide loend põhines ravimiregistril ja kliinikumi ravimiformularil ning ravimite müügiandmed saadi Ravimiametist. Tulemused ja järeldused. Vaadeldud aastatel samastati perekonna või liigi tasemel 829 mikroobi. Bakteritest domineerisid stafülokokid, hemofiilused, pneumokokid, enterobakterid, moraksellad ning viridans-grupi streptokokid. Kaks kolmandikku bakteritest olid testitud antibiootikumide suhtes tundlikud enam kui 80%. Bakterite tundlikkus Eestis kasutatud paiksete preparaatide suhtes oli järgmine: klooramfenikooli korral oli tundlikkus 89,2%, levofloksatsiini korral 91,2%, moksifloksatsiini puhul 92%, tobramütsiini puhul 90,5% ja tsiprofloksatsiini puhul 89,7%. Seega sobivad kõik loetletud preparaadid silmainfektsioonide empiiriliseks paikseks raviks. Viirustest tuvastati uuritud materjalides kõige enam lihtherpeseviirusi, järgnesid adenoviirused. Uuringu tulemused võimaldavad koostada silmainfektsioonide korral testitavate mikroobirühmapõhiste antibiootikumide loendeid ja luua analüüside tellimise lihtsustamiseks eraldi silmanakkuste diagnoosimise tellimusvormi.
description: Eesti Arst, 2023: Jaanuar
Trapped unitary two-component Fermi gases with up to ten particles
Creators: name: Yin, X. Y.
name: Blume, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The properties of two-component Fermi gases with zero-range interactions are universal. We use an explicitly correlated Gaussian basis set expansion approach to investigate small equal-mass two-component Fermi gases under spherically symmetric external harmonic confinement. At unitarity, we determine the ground state energy for systems with up to ten particles interacting through finite-range two-body potentials for both even and odd number of particles. We extrapolate the energies to the zero-range limit using a novel scheme that removes the linear and, in some cases, also the quadratic dependence of the ground state energies on the two-body range. Our extrapolated zero-range energies are compared with results from the literature. We also calculate the two-body Tan contact and structural properties.
description: 11 pages (7 figures) + 6 pages (10 figures)
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development
Creators: name: Kim, Yongbaek
name: Wang, Xian
name: Miliani De Marval, Paula L.
name: Sistrunk, Christopher
name: Rodriguez-Puebla, Marcelo L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: We have previously demonstrated that ras-mediated skin tumorigenesis depends on signaling pathways that act preferentially through cyclin D1 and D2. Interestingly, the expression of cyclin D3 inhibits skin tumor development, an observation that conflicts with the oncogenic role of D-type cyclins in the mouse epidermis. Here, we show that simultaneous up and downregulation of particular members of the D-type cyclin family is a valuable approach to reduce skin tumorigenesis. We developed the K5D3/cyclin D1−/− compound mouse, which overexpresses cyclin D3 but lacks expression of cyclin D1 in the skin. Similar to K5D3 transgenic mice, keratinocytes from K5D3/cyclin D1−/− compound mice show a significant reduction of cyclin D2 levels. Therefore, this model allows us to determine the effect of cyclin D3 expression when combined with reduced or absent expression of the remaining two members of the D-type cyclin family in mouse epidermis. Our data show that induced expression of cyclin D3 compensates for the reduced level of cyclin D1 and D2, resulting in normal keratinocyte proliferation. However, simultaneous ablation of cyclin D1 and downregulation of cyclin D2 via cyclin D3 expression resulted in a robust reduction in ras-mediated skin tumorigenesis. We conclude that modulation of the levels of particular members of the D-type cyclin family could be useful to inhibit tumor development and, in particular, ras-mediated tumorigenesis.
Accurate characterization of the stellar and orbital parameters of the exoplanetary system WASP-33 b from orbital dynamics
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: By using the most recently published Doppler tomography measurements and accurate theoretical modeling of the oblateness-driven orbital precessions, we tightly constrain some of the physical and orbital parameters of the planetary system hosted by the fast rotating star WASP-33. In particular, the measurements of the orbital inclination $i_{\rm p}$ to the plane of the sky and of the sky-projected spin-orbit misalignment $λ$ at two epochs about six years apart allowed for the determination of the longitude of the ascending node $Ω$ and of the orbital inclination $I$ to the apparent equatorial plane at the same epochs. As a consequence, average rates of change $\dotΩ_{\rm exp},~\dot I_{\rm exp}$ of this two orbital elements, accurate to a $\approx 10^{-2}~{\rm deg}~{\rm yr}^{-1}$ level, were calculated as well. By comparing them to general theoretical expressions $\dotΩ_{J_2},~\dot I_{J_2}$ for their precessions induced by an oblate star whose symmetry axis is arbitrarily oriented, we were able to determine the angle $i^{\star}$ between the line of sight the star's spin $S^{\star}$ and its first even zonal harmonic $J_2^{\star}$ obtaining $i^{\star} = 142^{+10}_{-11}~{\rm deg},~J_2^{\star} = (2.1^{+0.8}_{-0.5})\times 10^{-4}.$ As a by-product, the angle between $S^{\star}$ and the orbital angular momentum $L$ is as large as about $ψ\approx 100$ deg $(ψ^{2008} = 99^{+5}_{-4}~{\rm deg},~ψ^{2014} = 103^{+5}_{-4}~{\rm deg})$, and changes at a rate $\dotψ= 0.7^{+1.5}_{-1.6}~{\rm deg}~{\rm yr}^{-1}$. The predicted general relativistic Lense-Thirring precessions, or the order of $\approx 10^{-3}~{\rm deg}~{\rm yr}^{-1}$, are, at present, about one order of magnitude below the measurability threshold.
description: LaTex2e, 1 figure, 1 table, 8 pages. Finale version accepted for publication in Monthly Notices of the Royal Astronomical Society (MNRAS)
(401671) Kattie Ogilvie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DNA excision repair: Where do all the dimers go?
Creators: name: Kemp, Michael G.
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Exposure of cells to UV light from the sun causes the formation of pyrimidine dimers in DNA that have the potential to lead to mutation and cancer. In humans, pyrimidine dimers are removed from the genome in the form of ~30 nt-long oligomers by concerted dual incisions. Though nearly 50 y of excision repair research has uncovered many details of UV photoproduct damage recognition and removal, the fate of the excised oligonucleotides and, in particular, the ultimate fate of the chemically very stable pyrimidine dimers remain unknown. Physiologically relevant UV doses introduce hundreds of thousands of pyrimidine dimers in diploid human cells, which are excised from the genome within ~24 h. Once removed from the genome, “where do all the dimers go?” In a recent study we addressed this question. Although our study did not determine the fate of the dimer itself, it revealed that the excised ~30-mer is released from the duplex in a tight complex with the transcription/repair factor TFIIH. This finding combined with recent reports that base and oligonucleotide products of the base and double-strand break repair pathways also make stable complexes with the cognate repair enzymes, and that these complexes activate the MAP kinase and checkpoint signaling pathways, respectively, raises the possibility that TFIIH-30-mer excision complexes may play a role in signaling reactions in response to UV damage.
title: Role of X-ray diagnostics on the choice of surgical tactics in the treatment of esophageal atresia.
Creators: name: Maryniuk, Hanna
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Gastrointestinal tract
subject: Thorax
subject: Plain radiographic studies
subject: Surgery
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review material for better understanding the reason for using x-Ray in esophageal atresia. To highlight key points in image descriptions of patients with esophageal atresia. To create a clear algorithm for patient management tactics for surgeons...
title: Weltrecht^2 Backbone Documents“ - here “Paper“: “Multidisciplinary Constitutional Law Scholarship from Germany and the EU” submitted to World Congress of Constitutional Law in Dec. 2022
Creators: name: Schmid, Viola
Publisher: name: UNSPECIFIED
Year: 2023

description: “Weltrecht^2” addresses the process of digitalization and the economization of state and private (information) value chains since the inception of cyberspace as the 5th dimension of being. The designation “Weltrecht^2” has been chosen for a World Congress of Constitutional Law (WCCL) with the conference title "Constitutional Transformations" held in South Africa, Johannesburg from December 5 to 9, 2022. One workshop topic on the agenda concerns "Constitutional law scholarship and constitutional transformation: actors and influences.” This “Backbone Document” presents the 10,000-word ‘paper’ titled “Weltrecht^2 - Multidisciplinary constitutional law scholarship from Germany and the EU”. This Cylaw Report XXXXII forms part of the “Weltrecht^2-Series” and builds directly (1) onto Cylaw Report XXXXIII: Viola Schmid in 2023/02 --> here “WCCL - LAUNCH “: “MULTIDISCIPLINARY CONSTITUTIONAL LAW SCHOLARSHIP FROM GERMANY AND THE EU” ON DEC. 7TH 2022 [soon to be published] (2) onto Cylaw Report XXXXI: Viola Schmid in 2023/01: „Weltrecht^2 Entourage Documents“, (Version 2) --> here: A STANDARD FOR A UNIVERSAL (TECHNOLOGY) LAW LECTURE (2018) (3) onto Cylaw Report XXXVI: Der kleinste gemeinsame Nenner - 13 Basics zum Cyberlaw? (The smallest common denominator – 13 basics for Cyberlaw?) ["Cyberlaw All 2 - 2014"] (2016) in German Language [GL], as well as (4) the concomitant publication Forschungsmatrix für eine globale Cyberlaw-Agenda – „Cyberlaw All 4 – 2016“, (research matrix for a global cyberlaw agenda -„Cyberlaw All 4 – 2016 ) in: Schweighofer et al. (Ed.), Networks – Proceedings of the 19. International Legal Informatics Symposion (IRIS 2016), p. 441 – 448 also in German language [GL].
Functional error estimators for the adaptive discretization of inverse problems
Creators: name: Clason, Christian
name: Kaltenbacher, Barbara
name: Wachsmuth, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: So-called functional error estimators provide a valuable tool for reliably estimating the discretization error for a sum of two convex functions. We apply this concept to Tikhonov regularization for the solution of inverse problems for partial differential equations, not only for quadratic Hilbert space regularization terms but also for nonsmooth Banach space penalties. Examples include the measure-space norm (i.e., sparsity regularization) or the indicator function of an $L^\infty$ ball (i.e., Ivanov regularization). The error estimators can be written in terms of residuals in the optimality system that can then be estimated by conventional techniques, thus leading to explicit estimators. This is illustrated by means of an elliptic inverse source problem with the above-mentioned penalties, and numerical results are provided for the case of sparsity regularization.
Effect of circadian clock mutations on DNA damage response in mammalian cells
Creators: name: Ye, Rui
name: Ozturk, Nuri
name: Reardon, Joyce T.
name: Gaddameedhi, Shobhan
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The circadian clock is a global regulatory mechanism that confers daily rhythmicity on many biochemical and physiological functions, including DNA excision repair in mammalian organisms. Here, we investigated the effect of the circadian clock on the major DNA damage response pathways by using mouse cell lines mutated in genes encoding proteins in the positive (Bmal1, CLOCK) or negative (Cry 1/2, Per 1/2) arms of the transcription-translation feedback loop that generates the circadian clock. We find that cells mutated in these genes are indistinguishable from wild-type in their response to UV, ionizing radiation and mitomycin C. We conclude that either the majority of DNA damage response reactions are not controlled by the circadian clock or that, even if such a control exists at the organism level, it is supplanted by homeostatic control mechanisms at the cellular level in tissue culture. We suggest that caution must be exercised in extrapolating from experiments in tissue culture to whole animals with respect to the effect of the circadian clock on cellular response to DNA damaging agents.
title: X-ray scatter correction in breast CT images using deep learning
Creators: name: Pautasso, Juan
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Cone beam CT
subject: Computer Applications-Detection, diagnosis
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Although mammography and digital breast tomosynthesis have been widely used to detect and diagnose breast cancer, their performance is hampered by their lack or limited three-dimensional information. This results in some breast lesions going...
(401672) James Robertson Fleming
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401668) William Thomas Grieve
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease
Creators: name: Maurer, Kirk J.
name: Al Saei, Ahmed
name: Daugherity, Erin K.
name: Rogers, Arlin B.
name: Abi Abdallah, Delbert
name: Weiss, Robert S.
name: Balmus, Gabriel
name: Moore, Elizabeth S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Steatoapoptosis is a hallmark of non-alcoholic fatty liver disease (NAFLD) and is an important factor in liver disease progression. We hypothesized that increased reactive oxygen species resulting from excess dietary fat contribute to liver disease by causing DNA damage and apoptotic cell death, and tested this by investigating the effects of feeding mice high fat or standard diets for 8 weeks. High fat diet feeding resulted in increased hepatic H2O2, superoxide production, and expression of oxidative stress response genes, confirming that the high fat diet induced hepatic oxidative stress. High fat diet feeding also increased hepatic steatosis, hepatitis and DNA damage as exemplified by an increase in the percentage of 8-hydroxyguanosine (8-OHG) positive hepatocytes in high fat diet fed mice. Consistent with reports that the DNA damage checkpoint kinase Ataxia Telangiectasia Mutated (ATM) is activated by oxidative stress, ATM phosphorylation was induced in the livers of wild type mice following high fat diet feeding. We therefore examined the effects of high fat diet feeding in Atm-deficient mice. The prevalence of apoptosis and expression of the pro-apoptotic factor PUMA were significantly reduced in Atm-deficient mice fed the high fat diet when compared with wild type controls. Furthermore, high fat diet fed Atm−/− mice had significantly less hepatic fibrosis than Atm+/+ or Atm+/− mice fed the same diet. Together, these data demonstrate a prominent role for the ATM pathway in the response to hepatic fat accumulation and link ATM activation to fatty liver-induced steatoapoptosis and fibrosis, key features of NAFLD progression.
title: Quantitative ultrasound steatometry in the assesment of the effectiveness of non-drug metabolic syndrome therapie
Creators: name: Venidiktova, Darya
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Ultrasound
subject: Experimental investigations
subject: Endocrine disorders

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Diagnostic evaluation of the effectiveness of non-drug therapy in patients with metabolic...
Casimir effect of two conducting parallel plates in a general weak gravitational field
Creators: name: Nazari, Borzoo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We calculate the finite vacuum energy density of the scalar and electromagnetic fields inside a Casimir apparatus made up of two conducting parallel plates in a general weak gravitational field. The metric of the weak gravitational field has a small deviation from flat spacetime inside the apparatus and we find it by expanding the metric in terms of small parameters of the weak background. We show that the found metric can be transformed via a gauge transformation to the Fermi metric. We solve the Klein-Gordon equation exactly and find mode frequencies in Fermi spacetime. Using the fact that the electromagnetic field can be represented by two scalar fields in the Fermi spacetime, we find general formulas for the energy density and mode frequencies of the electromagnetic field. Some well-known weak backgrounds are examined and consistency of the results with the literature is shown.
description: 25 pages, 1 figure
title: The omental cake sign: differences and similarities in adults and children
Creators: name: Fichera, Giulia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: CT
subject: Diagnostic procedure
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To provide, according to the literature and the experience gained in our tertiary center, a comprehensive overview of the main similarities and differences in terms of etiology and features at Computed Tomography (CT) of the omental cake sign in...
(401669) Adam Smith Giles
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Distinguishing between Wilms’ tumor and neuroblastoma at imaging
Creators: name: Fichera, Giulia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Paediatric
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To provide, according to the literature and the experienced gained in our tertiary center, a comprehensive overview of the diagnostic path of children affected by Wilms’ tumor or neuroblastoma and describe the main findings at imaging allowing the...
Entangled polymer complex as Higgs phenomena
Creators: name: Kim, Ki-Seok
name: Dutta, Sandipan
name: Jho, YongSeok
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We derive an effective Maxwell-London equation for entangled polymer complex under the topological constraint, borrowing the theoretical framework from the topological field theory. We find that the transverse current flux of the test polymer chain, surrounded with entangled chains, decays exponentially from its average position with finite penetration depth, which is analogous to the magnetic-field decay in a superconductor (SC). Like as the mass acquirement of photons in SC is the origin of the magnetic-field decay, the polymer earns uncrossible intersections along the chain due to the preserved linking number, which restricts the deviation of the transverse polymer current in the normal direction. Interestingly, this picture is well incorporated with the most successful phenomenological theory of the so called tube model, of which researchers have long pursued its microscopic origin. The correspondence of our equation of motion to the tube model claims that the confining tube potential is a consequence of the topological constraint (linking number). The tube radius is attributed to the decay length, and increasing the retracting force at intersections or increasing the number of intersections (linking number), the tube becomes narrow and tighter. It further shows that the probability of the tube leakage decays exponentially with the decay length of tube radius.
The Detached Self: Investigating the Effect of Depersonalisation on Self-Bias in the Visual Remapping of Touch
Creators: name: Farmer, Harry
name: Cataldo, Antonio
name: Nagela Adel
name: Wignall, Emma
name: Gallese, Vittorio
name: Deroy, Ophelia
name: Hamilton, Antonia
name: Ciaunica, Anna
Publisher: name: Brill Online
Year: 2020
Subjects: subject: 170112 Sensory Processes, Perception and Performance
subject: FOS: Psychology

description: There is a growing consensus that our most fundamental sense of self is structured by the ongoing integration of sensory and motor information related to our own body. Depersonalisation (DP) is an intriguing form of altered subjective experience in which people report feelings of unreality and detachment from their sense of self. The current study used the visual remapping of touch (VRT) paradigm to explore self-bias in visual–tactile integration in non-clinical participants reporting high and low levels of depersonalisation experiences. We found that the high-DP group showed an increased overall VRT effect but a no-self-face bias, instead showing a greater VRT effect when observing the face of another person. In addition, across all participants, self-bias was negatively predicted by the occurrence of anomalous body experiences. These results indicate disrupted integration of tactile and visual representations of the bodily self in those experiencing high levels of DP and provide greater understanding of how disruptions in multisensory perception of the self may underlie the phenomenology of depersonalisation.
title: Diffusion tensor magnetic resonance imaging in evaluation of prognostic outcome in ischemic and hemorrhagic stroke patients
Creators: name: Talwadker, Adish
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Imaging sequences
subject: Ischaemia / Infarction

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To establish the prognostic accuracy of DTI i.e. magnetic resonance tractography and fractional anisotropy in assessing prognostic outcome in stroke patients, in comparison to neurological assessment scores that are currently in use, namely the...
(401670) Christopher Kerr
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.