title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½ÐµÐ¹ÑÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ¸Ð¿ÐµÐ¿ÑÐ¸Ð´Ð° Ñ ÐÐÐ Ð¸ ÑÐµÐ³ÑÐ»ÑÑÐ¾ÑÐ½ÑÐ¼Ð¸ Ð±ÐµÐ»ÐºÐ°Ð¼Ð¸
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: Ð¡Ð°Ð»Ð»Ñ, Ð¢Ð°ÑÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐÐµÐ»ÐºÐ¸
ÐÐµÐ¹ÑÐ¾Ð½Ñ
ÐÐ»ÐµÑÐºÐ° (Ð±Ð¸Ð¾Ð»)
ÑÑÐ°ÑÐµÐ½Ð¸Ðµ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°
Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÐµ Ð¼Ð°ÑÐºÐµÑÑ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ°ÑÐµÐ½Ð¸Ñ
Ð½ÐµÐ¹ÑÐ¾Ð¿ÑÐ¾ÑÐµÐºÑÐ¸Ñ
aging brain
molecular senescence markers
neuroprotection

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð° EDR Ð½Ð° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð¼Ð¾Ð»ÐµÐºÑÐ» Ð² Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ñ Ð¿ÑÐ¸ ÑÑÐ°ÑÐµÐ½Ð¸Ð¸. Ð¢Ð°ÐºÐ¶Ðµ Ð±ÑÐ»Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ ÐÐÐ-Ð¿ÐµÐ¿ÑÐ¸Ð´Ð½ÑÐµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð³Ð¾ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ (MOE 2014). Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¼Ð°ÑÐºÐµÑÐ¾Ð² ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² Ð¿ÑÐ¸ Ð¸Ñ ÑÑÐ°ÑÐµÐ½Ð¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð¼Ð¾Ð»ÐµÐºÑÐ» p53, p21, p16, AIF, Sirt6, Ku70, Ku80 Ð² ÐºÑÐ»ÑÑÑÑÐ°Ñ ÐºÐ»ÐµÑÐ¾Ðº ÐºÐ¾ÑÑ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð°. Ð¡Ð¸Ð½ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð¿ÐµÐ¿ÑÐ¸Ð´ EDR ÑÐ¼ÐµÐ½ÑÑÐ°Ð» ÑÑÐ¾Ð²ÐµÐ½Ñ Ð°Ð¿Ð¾Ð¿ÑÐ¾Ð·Ð° Ð² ÐºÑÐ»ÑÑÑÑÐµ ÐºÐ»ÐµÑÐ¾Ðº Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² ÐºÑÑÑÑ Ð¿ÑÐ¸ ÑÑÐ°ÑÐµÐ½Ð¸Ð¸, ÑÐ½Ð¸Ð¶Ð°Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð¼Ð°ÑÐºÐµÑÐ¾Ð² Ð°Ð¿Ð¾Ð¿ÑÐ¾Ð·Ð° p53, p21, AIF, Ð¸ Ð¿Ð¾Ð²ÑÑÐ°Ð» ÑÑÐ¾Ð²ÐµÐ½Ñ Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð² ÐºÑÐ»ÑÑÑÑÐ°Ñ Ð½ÐµÐ¹ÑÐ¾Ð½Ð¾Ð² Ð¿ÑÐ¸ Ð¸Ñ ÑÑÐ°ÑÐµÐ½Ð¸Ð¸, ÑÐ²ÐµÐ»Ð¸ÑÐ¸Ð²Ð°Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð¼Ð°ÑÐºÐµÑÐ¾Ð² ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð¹ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¸Ð¸ Sirt6, Ku80. Ð¡ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÐºÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð±ÑÐ»Ð° Ð½Ð°Ð¹Ð´ÐµÐ½Ð° ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð²ÑÐ³Ð¾Ð´Ð½Ð°Ñ ÐºÐ¾Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ñ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð° EDR, Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð¾Ð³Ð¾ Ð´Ð¾ÐºÐ¸Ð½Ð³Ð° Ð±ÑÐ» Ð¿ÑÐµÐ´ÑÐºÐ°Ð·Ð°Ð½ Ð¿ÑÐµÐ´Ð¿Ð¾ÑÑÐ¸ÑÐµÐ»ÑÐ½ÑÐ¹ ÑÐ°Ð¹Ñ ÑÐ²ÑÐ·ÑÐ²Ð°Ð½Ð¸Ñ GCCG, ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð½ÑÐ¹ Ð² Ð¿ÑÐ¾Ð¼Ð¾ÑÐ¾ÑÐ½Ð¾Ð¹ Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð³ÐµÐ½Ð¾Ð², Ð¿ÑÐ¾Ð´ÑÐºÑÐ°Ð¼Ð¸ ÐºÐ¾ÑÐ¾ÑÑÑ ÑÐ²Ð»ÑÑÑÑÑ Ð¸Ð·ÑÑÐµÐ½Ð½ÑÐµ ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÐµ Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ.
description: The effect of peptide EDR on the expression of signaling molecules in neurons was studied during aging. Moreover, molecular modeling methods (MOE 2014) were used to investigate the DNA-peptide interactions. The expression of molecules p53, p21, p16, AIF, Sirt6, Ku70, Ku80 in cortex cell cultures was revealed as markers of functional activity of neurons during their aging. The synthetic peptide EDR reduced apoptosis in neuronal cell culture in aging rats via decreasing the expression of markers of apoptosis p53, p21, AIF, and increased the cell renewal rate in neuronal cultures during their aging via increasing the expression of markers of cell proliferation Sirt6, Ku80.The energetically favorable conformation of peptide EDR was found using conformational analysis, the preferred binding site GCCG located in promoter region of genes was predicted by molecular docking method for peptide EDR. The studied signaling molecules are the products of the investigated genes.