cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Delayed versus immediate cord clamping in dichorionic twins <32 weeks: a retrospective study
Creators: name: Wang, Li
name: Ou, Jiangfeng
name: Wu, Yan
name: Xiao, Guiyuan
name: Gong, Hua
name: Chen, Wen
name: Zhou, Ligang
name: Zhong, Xiaoyun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Strong evidence imply that delayed cord clamping (DCC) provides significant benefits for singleton neonates. However, there is little information about the safety or efficacy of DCC in twins to recommend for or against DCC in twins in guidelines. We aimed to determine the effect of DCC on dichorionic twins born at <32 weeks of gestation. This is a retrospective cohort study comparing the neonatal and maternal outcomes of immediate cord clamping (ICC) [<15 second (s)] versus DCC (at 60 s). Generalized estimating equations models were performed accounting for twin correlation. A total of 82 pairs of twins (DCC: 41; ICC: 41) were included in analysis. The primary outcome of death before discharge occurred in 3.66% of twins in the DCC group and 7.32% in the ICC group, without a significant difference between the groups. Compared to ICC group, DCC was associated with increased hemoglobin levels [β1 coefficient 6.51; 95% confidence interval (CI) 0.69–12.32. β2 coefficient 5.80; 95% CI 0.07–11.54] at 12–24 h of life. There were no significant differences between the groups in neonatal death, neonatal major morbidities and maternal bleeding complications, although DCC was associated with higher estimated maternal blood loss in the cesarean section group (p = .005). DCC for 60 s in dichorionic twins born at <32 weeks of gestation was associated with increased neonatal hemoglobin levels, when compared with ICC. The finding of a higher estimated maternal blood loss by cesarean section in the DCC group calls for further trials to assess maternal safety of this procedure in this patient population.
sj-pdf-1-jcb-10.1177_0271678X20965500 - Supplemental material for Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib
Creators: name: Tournier, Nicolas
name: Goutal, Sebastien
name: Mairinger, Severin
name: Lozano, Irene H
name: Filip, Thomas
name: Sauberer, Michael
name: Caillé, Fabien
name: Breuil, Louise
name: Stanek, Johann
name: Freeman, Anna F
name: Novarino, Gaia
name: Truillet, Charles
name: Wanek, Thomas
name: Langer, Oliver
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X20965500 for Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib by Nicolas Tournier, Sebastien Goutal, Severin Mairinger, Irene H Lozano, Thomas Filip, Michael Sauberer, Fabien Caillé, Louise Breuil, Johann Stanek, Anna F Freeman, Gaia Novarino, Charles Truillet, Thomas Wanek and Oliver Langer in Journal of Cerebral Blood Flow & Metabolism
Additional file 1 of Rates and associations of relapse over 5 years of 2649 people with bipolar disorder: a retrospective UK cohort study
Creators: name: Hett, Danielle
name: Morales-Muñoz, Isabel
name: Durdurak, Buse Beril
name: Carlish, Max
name: Marwaha, Steven
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health
Virology

description: Additional file 1: Table S1. Overview of naturalistic studies reporting BD relapse rates.
SMAP__submission_-_supplementary – Supplemental material for The Saskatchewan Medication Assessment Program for Patients With Renal Failure: A Qualitative Study to Understand Health Care Provider Perspectives
Creators: name: Ahmed, Anan
name: Blackburn, David F.
name: Evans, Charity
name: Rosaasen, Nicola
name: Mansell, Holly
Publisher: name: SAGE Journals
Year: 2020
Subjects: Medicine

description: Supplemental material, SMAP__submission_-_supplementary for The Saskatchewan Medication Assessment Program for Patients With Renal Failure: A Qualitative Study to Understand Health Care Provider Perspectives by Anan Ahmed, David F. Blackburn, Charity Evans, Nicola Rosaasen and Holly Mansell in Canadian Journal of Kidney Health and Disease
Supplemental material for this article is available online.
Creators: name: Farquharson, Kelly
name: Therrien, Michelle
name: Barton-Hulsey, Andrea
name: Brandt, Ann F.
Publisher: name: SAGE Journals
Year: 2022
Subjects: Education

description: Supplemental material for How to Recruit, Support, and Retain Speech-Language Pathologists in Public Schools by Kelly Farquharson, Michelle Therrien, Andrea Barton-Hulsey, Ann F. Brandt in Journal of School Leadership
Drinking motives and their associations with alcohol use among adolescents in Sweden
Creators: name: Sjödin, L
name: Larm, P
name: Karlsson, P
name: Livingston, Michael
name: Raninen, Jonas
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Aims: Previous studies have shown a close association between drinking motives and drinking behaviour among adolescents. However, there is a lack of evidence from the Nordic countries since few studies covering this topic have been carried out in this context. The present study among Swedish adolescents aims to examine (1) the prevalence of different drinking motives, (2) how drinking motives are associated with drinking frequency and heavy drinking frequency, and (3) whether the associations are moderated by sex. Methods: A nationally representative sample (n = 5,549) of Swedish adolescents (aged 15–16 years) answered a questionnaire in school. Of these, 2,076 were drinkers and were included in our study. Eighteen items from the Modified Drinking Motives Questionnaire-Revised (Modified DMQ-R) were used. Bivariate relationships between motives and drinking were examined with correlations. Linear regression models were used to assess the links between motives and drinking. Moderating effects of sex were examined with interactions. Results: Most common were social motives, followed by enhancement, coping-anxiety, coping-depression, and conformity motives. Coping-depression motives were slightly more common among girls. Conformity motives were associated with a lower frequency of drinking and heavy drinking while enhancement, social and coping-depression motives were associated with a higher frequency of both outcomes. No associations were found for coping-anxiety motives. No moderation effect of sex was found. Conclusions: Approach motives (social/enhancement) are the most prevalent drinking motives among Swedish adolescents. These also have the strongest association for both frequency of drinking and frequency of heavy drinking. This shows that Swedish adolescents drink to achieve something positive, rather than to avoid something negative, raising implications for prevention and intervention.
Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment
Creators: name: HM Al-Aamri
name: Irving, Helen
name: C Bradley
name: Meehan-Andrews, Terri
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Daunorubicin is used clinically in the treatment of myeloma, acute lymphatic and myelocytic leukaemia. The toxic lesions caused by daunorubicin induce various modes of cell death, including apoptosis. Apoptosis is highly regulated programmed cell death that can be initiated mainly via two pathways, through death receptors (extrinsic) or involvement of the mitochondria (intrinsic). Induction of apoptosis via these pathways has been alluded following treatment with daunorubicin, but never compared in acute lymphoblastic leukaemia over a time course. Methods: This study investigated the mechanisms of daunorubicin induced apoptosis in the treatment of CCRF-CEM, MOLT-4 (acute T-lymphoblastic leukaemia) and SUP-B15 (acute B-lymphoblastic leukaemia) cells. Cells were treated with daunorubicin for 4 h, and then placed in recovery medium (without daunorubicin) for 4 h, 12 h and 24 h. Apoptotic response was analysing using annexin-V expression, caspase activity, mitochondrial membrane potential change and an array to detect 43 apoptotic proteins. Results: Daunorubicin induced apoptosis in all leukemic cell lines, but with different levels and duration of response. Both apoptosis levels and caspase activity increased after four hours recovery then declined in CCRF-CEM and MOLT-4 cells. However, SUP-B15 cells displayed initially comparable levels but remained elevated over the 24 h assessment period. Changes in mitochondrial membrane potential occurred in both MOLT-4 and CCRF-CEM cells but not in SUP-B15 cells. Expression of apoptotic proteins, including Bcl-2, Bax, caspase 3 and FADD, indicated that daunorubicin potentially induced both extrinsic and intrinsic apoptosis in both CCRF-CEM and MOLT-4 cells, but only extrinsic apoptosis in SUP-B15 cells. Conclusions: This study describes variations in sensitivities and timing of apoptotic responses in different leukaemia cell lines. These differences could be attributed to the lack of functional p53 in coordinating the cells response following cytotoxic treatment with daunorubicin, which appears to delay apoptosis and utilises alternative signalling mechanisms that need to be further explored.
Revolutionizing transdermal drug delivery: harnessing the power of nanofibers for drug delivery
Creators: name: Patel, Riya
name: Pandya, Jinkal
name: Patel, Kavisha
name: Joshi, Harsh
name: Parmar, Maneesha
name: Shah, Nehal
name: Shah, Shreeraj
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: More than 300 disorders associated with the human skin have been identified, constituting a global burden of approximately 880 million patients. This review looks at the occurrences of such conditions and stresses the need for optimized topical drug delivery systems which will reduce localized pharmacological side effects while maximizing skin diseases and systemic diseases symptoms treatment. It lists topical anti-inflammatory/immunosuppressant drugs like corticosteroids, antiviral, antifungal, antibacterial/antiseptic, local anesthetics, and antineoplastic drugs with other drugs affecting tissues via physical or chemical processes. Also, it emphasizes the various types of pharmaceutical dosages, such as semisolid, liquid, spray, and powder in topical treatments. These studies show the importance of effective delivery of drugs to the stratum affected areas, relief of associated signs, and enhancement of therapeutic results in the treatment of skin diseases in humans. Skin issues affect 900 million globally, emphasizing the need for efficient drug delivery.This review delves into medication classifications and their role in treating skin problems and systemic diseases.Analysis of medication classes and forms underscores tailored delivery systems’ importance.Understanding skin disorder frequency and using suitable methods are crucial for effective treatment. Skin issues affect 900 million globally, emphasizing the need for efficient drug delivery. This review delves into medication classifications and their role in treating skin problems and systemic diseases. Analysis of medication classes and forms underscores tailored delivery systems’ importance. Understanding skin disorder frequency and using suitable methods are crucial for effective treatment.
title: NEPS-SC5 survey data linked to administrative data of the IAB (NEPS-SC5-ADIAB)
Creators: name: Bachbauer, Nadine
name: Wolf, Clara
Publisher: name: Forschungsdatenzentrum der Bundesagentur für Arbeit (BA) im Institut für Arbeitsmarkt- und Berufsforschung (IAB)
Year: 2023
Subjects: subject: German administrative micro data
subject: labour market data
subject: data manual
subject: National Educational Panel Study
subject: survey data

description: Dieser Datenreport beschreibt die verknüpften Erhebungsdaten des Nationalen Bildungspanels der Startkohorte 5 „Hochschulstudium und Übergang in den Beruf“ (NEPS-SC5) mit administrativen Daten des Instituts für Arbeitsmarkt- und Berufsforschung (IAB).
description: FDZ-Datenreport
An Inescapable Crisis: Fuel Poverty and the Private Rented Sector
Creators: name: Snell, Carolyn
name: Browning, Anna
name: Pleace, Nicholas
name: Cutler, Sara
Publisher: name: Zenodo
Year: 2025

description: Households in the Private Rented Sector (PRS)  have been especially impacted by the energy crisis. Some PRS tenants, especially those on low incomes and benefits, have faced homelessness as a result of escalating energy and housing costs, whilst others, higher up the income scale and in full time employment, have shown ‘symptoms’ of fuel poverty for the first time. This can be attributed to a combination of poor housing conditions, high energy prices and rents, and limited regulation and enforcement within the sector.

Living in the PRS during the crisis has had significant social, financial, and psychological impacts, with tenants giving up tenancies, drastically reducing energy use, and making long-term decisions that affect family and relationships.

This brief emphasises the need for urgent policy action to improve PRS energy efficiency and regulation, a move that would benefit public health, social inclusion, and contribute to Net Zero goals.
Curcumin-crosslinked single-chain polymer nanoparticles as potential polymer-drug conjugates
Creators: name: Batu, Hatice Kübra
name: Civelek, Dilek Öztürk
name: Temel, Binnur Aydogan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: Single-chain polymer nanoparticles (SCNPs) conjugated with curcumin were developed via Williamson etherification, offering a promising platform for drug delivery. Poly[(poly(ethylene glycol) methyl ether methacrylate)-r-(2-bromoethyl methacrylate)] was synthesized by reversible addition-fragmentation chain- transfer (RAFT) polymerization, with an 80:20 ratio chosen for optimal properties. Curcumin conjugation to 2-bromoethyl methacrylate (BEMA) units was confirmed through UV-Vis and NMR spectroscopy. The obtained SCNPs exhibited reduced molecular weights and hydrodynamic diameters (<7.66 nm) compared to their polymer precursors as confirmed by GPC and DLS. TEM analyses revealed that the obtained SCNPs exhibited spherical morphology. SCNP-2 exhibited pH-responsive curcumin release, with a cumulative release of 48% at pH 5.0 and 8% at pH 7.4 over 20 d. Cellular uptake studies revealed significant SCNP-2 accumulation in MDA-MB-231 cells. Cytotoxicity assays showed selective toxicity against cancer cells, while the polymer alone exhibited no cytotoxicity, highlighting its safety. These findings suggest that curcumin-conjugated SCNPs have potential as targeted cancer therapy agents.
Supplementary_Table_S1 – Supplemental material for Clinical features of patients with small cell lung cancer and idiopathic pulmonary fibrosis treated with chemotherapy or chemoradiotherapy
Creators: name: Kanaji, Nobuhiro
name: Shimizu, Junichi
name: Sakai, Kenichiro
name: Ueda, Yutaka
name: Miyawaki, Hiroshi
name: Watanabe, Naohiro
name: Uemura, Takehiro
name: Hida, Toyoaki
name: Inoue, Takuya
name: Watanabe, Naoki
name: Oohara, Yasuhiro
name: Dobashi, Hiroaki
name: Mikiya Kato
name: Norimitsu Kadowaki
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, Supplementary_Table_S1 for Clinical features of patients with small cell lung cancer and idiopathic pulmonary fibrosis treated with chemotherapy or chemoradiotherapy by Nobuhiro Kanaji, Junichi Shimizu, Kenichiro Sakai, Yutaka Ueda, Hiroshi Miyawaki, Naohiro Watanabe, Takehiro Uemura, Toyoaki Hida, Takuya Inoue, Naoki Watanabe, Yasuhiro Oohara, Hiroaki Dobashi, Mikiya Kato and Norimitsu Kadowaki in Therapeutic Advances in Respiratory Disease
Association of serum folate levels during pregnancy and prenatal depression
Creators: name: Avalos, Lyndsay A.
name: Nance, Nerissa
name: Caan, Bette
name: Sujan, Ayesha C.
name: Uriu-Adams, Janet Y.
name: Li, De-Kun
name: Quesenberry, Charles P.
name: Hedderson, Monique M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: To evaluate the association between serum folate levels during pregnancy and prenatal depression and the extent to which obesity may modify this relationship. This secondary data analysis leveraged data from a previous study of pregnant Kaiser Permanente Northern California participants who completed a survey and provided a serum sample between 2011 and 2013. Serum folate was assessed using the Center for Disease Control’s Total Folate Serum/Whole Blood Microbiological Assay Method. A score of 15 or greater on the Center for Epidemiologic Studies Depression Scale was defined as prenatal depression. We used Poisson regression to estimate risk of prenatal depression given prenatal serum folate status (low/medium tertiles vs. high tertile) in the full sample and in subsamples of women with pre-pregnancy body mass index in the (a) normal range and (b) overweight/obese range. Of the sample, 13% had prenatal depression. Combined low/medium folate tertiles was associated with prenatal depression (adjusted relative risk [aRR] = 1.97, 95% confidence interval [CI]: 0.93–4.18), although results did not reach statistical significance. This relationship was stronger among women with overweight/obesity than women with normal weight (aRR: 2.61, 95% CI: 1.01–6.71 and aRR: 1.50, 95% CI: 0.34–6.66, respectively). Results suggest an association between lower pregnancy folate levels and prenatal depression that may be stronger among women with overweight or obesity. Future studies need to clarify the temporal sequence of these associations.
Sampling strategies, techniques and curation of the Swedish Environmental Specimen Bank
Creators: name: Jerve, Anna
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on Sampling strategies, techniques and curation of the Swedish Environmental Specimen Bank by Senior Assistant Anna Jerve of Senior Assistant The Swedish Museum of Natural History Stockholm Sweden for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Biomarkers for cancer cachexia: A mini review
Creators: name: Cao, Zhipeng
name: Zhao, Kening
name: Jose, Irvin
name: Hoogenraad, Nick
name: Murray-Rust, Laura
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Cancer cachexia is a common condition in many cancer patients, particularly those with advanced disease. Cancer cachexia patients are generally less tolerant to chemotherapies and radiotherapies, largely limiting their treatment options. While the search for treatments of this condition are ongoing, standards for the efficacy of treatments have yet to be developed. Current diagnostic criteria for cancer cachexia are primarily based on loss of body mass and muscle function. However, these criteria are rather limiting, and in time, when weight loss is noticeable, it may be too late for treatment. Consequently, biomarkers for cancer cachexia would be valuable adjuncts to current diagnostic criteria, and for assessing potential treatments. Using high throughput methods such as “omics approaches”, a plethora of potential biomarkers have been identified. This article reviews and summarizes current studies of biomarkers for cancer cachexia.
Antidepressant use during pregnancy and the risk for gestational diabetes: a systematic review and meta-analysis
Creators: name: Wang, Xiao-yan
name: Ying, Xian-hua
name: Jiang, Hai-yin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Antidepressant medications are used by increasing numbers of pregnant women. The evidence on the relationship between antidepressant use during pregnancy and the risk for gestational diabetes mellitus (GDM) is inconsistent. We perform a systematic review and meta-analysis to assess the GDM risk associated with antidepressant exposure during pregnancy. We systematically searched the PubMed and EMBASE databases until December 2021. We sought observational studies assessing the association between gestational antidepressant use and GDM. Five observational studies were included in the analysis. Mothers exposed to antidepressants during pregnancy were at a significantly increased risk for GDM (relative risk [RR] 1.20, 95% confidence interval [CI] 1.11–1.30; p < .001). However, after considering confounding by indication, we observed no significant effect of antidepressant use during pregnancy on the risk of GDM (RR 1.13, 95% CI 1–1.28; p = .054; I2 = 0%). Independent of clinical indication, subgroup analysis based on individual antidepressants suggested that the risk was increased by venlafaxine or amitriptyline use, but not by selective serotonin reuptake inhibitors. The significant association between antidepressant exposure during pregnancy and GDM may be overestimated due to confounding by indication. However, the evidence remains insufficient, particularly for specific drug classes.
Additional file 1 of Three-dimensional comparison between the effects of mandibular advancement device and maxillomandibular advancement surgery on upper airway
Creators: name: Gurgel, Marcela
name: Cevidanes, Lucia
name: Costa, Fabio
name: Pereira, Rowdley
name: Cunali, Paulo
name: Bittencourt, Lia
name: Ruellas, Antonio
name: Gonçalves, Joao
name: Bianchi, Jonas
name: Chaves, Cauby
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Science Policy

description: Supplementary Material 1
Current Status of Loop-Mediated Isothermal Amplification Technologies for the Detection of Honey Bee Pathogens
Creators: name: Cameron, Timothy
name: Wiles, Danielle
name: Beddoe, Travis
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Approximately one-third of the typical human Western diet depends upon pollination for production, and honey bees (Apis mellifera) are the primary pollinators of numerous food crops, including fruits, nuts, vegetables, and oilseeds. Regional large scale losses of managed honey bee populations have increased significantly during the last decade. In particular, asymptomatic infection of honey bees with viruses and bacterial pathogens are quite common, and co-pathogenic interaction with other pathogens have led to more severe and frequent colony losses. Other multiple environmental stress factors, including agrochemical exposure, lack of quality forage, and reduced habitat, have all contributed to the considerable negative impact upon bee health. The ability to accurately diagnose diseases early could likely lead to better management and treatment strategies. While many molecular diagnostic tests such as real-time PCR and MALDI-TOF mass spectrometry have been developed to detect honey bee pathogens, they are not field-deployable and thus cannot support local apiary husbandry decision-making for disease control. Here we review the field-deployable technology termed loop-mediated isothermal amplification (LAMP) and its application to diagnose honey bee infections.
fig7_sup – Supplemental material for SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis
Creators: name: Schminke, Boris
name: Kauffmann, Philipp
name: Schubert, Andrea
name: Altherr, Manuel
name: Gelis, Thomas
name: Miosge, Nicolai
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, fig7_sup for SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis by Boris Schminke, Philipp Kauffmann, Andrea Schubert, Manuel Altherr, Thomas Gelis and Nicolai Miosge in CARTILAGE
The historic mine waste site at Nöckelberg, Austria – exploration and re-use potential
Creators: name: Pfleiderer,, Sebastian
name: Lipiarski, Piotr
name: Auer, Christian
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Mine waste
subject: Geochemical analyses
subject: Mineral waste

description: Project results presented at the international conference GeoSaxonia 2024 by START project partner GeoSphere Austria. This poster describes the study carried out on the exploration and re-use potential of the historic mining waste site at Nöckelberg, located near Leogang in the province of Salzburg, Austria.
Fluorescent nanogels as methotrexate transporters and their potential application in breast cancer therapy
Creators: name: Castro-Cortez, Andrea P.
name: Manzanares-Guevara, Lizbeth A.
name: Zizumbo-López, Arturo
name: Licea-Claverie, Angel
name: Licea-Navarro, Alexei F.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Nanometric drug delivery systems (DDSs) like nanogels are the future materials in nanomedicine against cancer. Fluorescent DDS have the potential to generate an application in theragnostics. In this study, intrinsic fluorescent nanogels (FNG) were synthesized via a scalable polymerization methodology based on surfactant-free emulsion polymerization of N,N′-diethyl(aminoethyl methacrylate) (DEAEM) and poly(ethylene glycol) methacrylate (PEGMA) using a fluorescent crosslinker. They were characterized by NMR, dynamic light scattering (DLS), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), TGA, and fluorescence spectroscopy. These nanogels are responsive; the hydrodynamic diameter and fluorescence intensity depend on the pH; the higher the pH, the smaller the size and the higher the fluorescence intensity. Methotrexate (MTX) was loaded into the nanogels for its physicochemical characterization and in vitro evaluation of cell viability against the breast cancer cell lines MDA-MB-231 and MCF-7. Cytotoxicity depended on the composition of the fluorescent nanogel; MTX showed resistance in the cell lines evaluated; however, once loaded into the nanogel, it was possible to develop a promising system for the delivery of MTX to potentially treat breast cancer, including triple-negative breast cancer cells.
A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast
Creators: name: Pal, Bhupinder
name: Chen, Y
name: Vaillant, F
name: Capaldo, BD
name: Joyce, R
name: Song, X
name: Bryant, VL
name: Penington, JS
name: Di Stefano, L
name: Ribera, N Tubau
name: Wilcox, S
name: Mann, GB
name: Papenfuss, AT
name: Lindeman, GJ
name: Smyth, GK
name: Visvader, JE
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic BRCA1+/– tissue, the major breast cancer subtypes, and pairs of tumors and involved lymph nodes. Elucidation of the normal breast microenvironment revealed striking changes in the stroma of post-menopausal women. Single-cell profiling of 34 treatment-naive primary tumors, including estrogen receptor (ER)+, HER2+, and triple-negative breast cancers, revealed comparable diversity among cancer cells and a discrete subset of cycling cells. The transcriptomes of preneoplastic BRCA1+/– tissue versus tumors highlighted global changes in the immune microenvironment. Within the tumor immune landscape, proliferative CD8+ T cells characterized triple-negative and HER2+ cancers but not ER+ tumors, while all subtypes comprised cycling tumor-associated macrophages, thus invoking potentially different immunotherapy targets. Copy number analysis of paired ER+ tumors and lymph nodes indicated seeding by genetically distinct clones or mass migration of primary tumor cells into axillary lymph nodes. This large-scale integration of patient samples provides a high-resolution map of cell diversity in normal and cancerous human breast.
title: Relationships
title: Youth Sexuality 9th Iteration. BZgA Fact Sheet
titleType: Subtitle
Creators: name: Scharmanski, Sara
name: Hessling, Angelika
name: Federal Centre For Health Education (BZgA)
Publisher: name: Federal Centre for Health Education (BZgA)
Year: 2022
Subjects: subject: 10000 Social Sciences
subject: adolescence
subject: contraception
subject: partner relationship
subject: partnership
subject: sex education
subject: sexually transmitted disease
subject: fidelity
subject: loyal partnership
subject: reproductive health
subject: sexual health
subject: sexually transmitted infections (STI)
subject: Geschlechtskrankheit
subject: Partnerbeziehung
subject: Sexualaufklärung
subject: Treue
subject: reproduktive Gesundheit
subject: sexuelle Gesundheit
subject: Adoleszenz
subject: Partnerschaft

description: This fact sheet is an overview of how adolescents and young adults in Germany live their relationships and of how widespread relationships are among adolescents.
description: Fact Sheet Sexuality Education, Contraception and Family Planning
description: Face-to-face interview: CAPI/CAMI
description: Self-administered questionnaire: Computer-assisted (CASI)
Extracellular vesicles in synovial fluid from rheumatoid arthritis patients contain mirnas with capacity to modulate inflammation
Creators: name: Foers, AD
name: Garnham, AL
name: Chatfield, S
name: Smyth, GK
name: Sim, Lesley
name: Hill, Andrew
name: Wicks, IP
name: Pang, KC
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: In rheumatoid arthritis (RA), extracellular vesicles (EVs) are associated with both the propagation and attenuation of joint inflammation and destruction. However, the specific EV content responsible for these processes is largely unknown. Investigations into identifying EV content are confounded by the challenges in obtaining high-quality EV preparations from synovial fluid. Imple-menting a size exclusion chromatography-based method of EV isolation, coupled with small RNA sequencing, we accurately characterised EV miRNAs in synovial fluid obtained from RA patients and investigated the differences between joints with high-and low-grade inflammation. Synovial fluid was obtained from the joints of 12 RA patients and, based on leukocyte counts, classified as either high (n = 7)-or low (n = 5)-grade inflammation. Using size exclusion chromatography, EVs were purified and small RNA was extracted and sequenced on a NextSeq 500. Sequencing reads were aligned to miRBase v21, and differences in miRNA profiles between RA patients with high-and low-grade joint inflammation were analysed. In total, 1972 distinct miRNAs were identified from RA synovial fluid EVs. miRNAs with less than five reads in fewer than five patients were filtered out, leaving 318 miRNAs for analysis. Analysis of the most abundant miRNAs suggested that they negatively regulate multiple genes relevant to inflammation, including signal transducer and activator of transcription 3 (STAT3), which lies downstream of IL-6 and has a pro-inflammatory role in RA. Synovial fluid from joints with high-grade inflammation contained 3.5-fold more EV miRNA per mL of synovial fluid (p = 0.0017). Seventy-eight EV miRNAs were differentially expressed between RA joints with high-and low-grade inflammation, and pathway analysis revealed that their target genes were commonly involved a variety of processes, including cellular apoptosis, proliferation and migration. Of the 49 miRNAs that were elevated in joints with high-grade inflammation, pathway analysis revealed that genes involved in cytokine-mediated signalling pathways were significantly enriched targets. In contrast, genes associated with reactive oxygen species signalling were significantly enriched as targets of the 29 miRNAs elevated in joints with low-grade inflammation. Our study identified an abundance of EV miRNAs from the synovial fluid of RA patients with the potential to modulate inflammation. In doing so, we defined potential mechanisms by which synovial fluid EVs may contribute to RA pathophysiology.
SeeCucumbers: using deep learning and drone imagery to detect sea cucumbers on coral reef flats
Creators: name: Li, JYQ
name: Duce, S
name: Joyce, KE
name: Xiang, Wei
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Sea cucumbers (Holothuroidea or holothurians) are a valuable fishery and are also crucial nutrient recyclers, bioturbation agents, and hosts for many biotic associates. Their ecological impacts could be substantial given their high abundance in some reef locations and thus monitoring their populations and spatial distribution is of research interest. Traditional in situ surveys are laborious and only cover small areas but drones offer an opportunity to scale observations more broadly, especially if the holothurians can be automatically detected in drone imagery using deep learning algorithms. We adapted the object detection algorithm YOLOv3 to detect holothurians from drone imagery at Hideaway Bay, Queensland, Australia. We successfully detected 11,462 of 12,956 individuals over 2.7 ha with an average density of 0.5 individual/m . We tested a range of hyperparameters to determine the optimal detector performance and achieved 0.855 mAP, 0.82 precision, 0.83 recall, and 0.82 F1 score. We found as few as ten labelled drone images was sufficient to train an acceptable detection model (0.799 mAP). Our results illustrate the potential of using small, affordable drones with direct implementation of open-source object detection models to survey holothurians and other shallow water sessile species. 2
9th OpenAIRE MONITOR Community Call / Public Webinar
Creators: name: Dimitropoulos, Harry
name: Malaguarnera, Giulia
Publisher: name: Zenodo
Year: 2025
Subjects: MONITOR dashboard
OpenAIRE

description: The 9th OpenAIRE Monitor Community Call was held as a Public Webinar on 18 March 2025

Topic: Service overview, new website launch, and subscription plans breakdown

Agenda:

Service overview

New website launch

Subscription plans breakdown

Q&A

Recording: https://youtu.be/-lwxqVAX5Vw
Additional file 1 of Single nucleotide polymorphism (SNP) markers for genetic diversity and population structure study in Ethiopian barley (Hordeum vulgare L.) germplasm
Creators: name: Yirgu, Mihret
name: Kebede, Mulugeta
name: Feyissa, Tileye
name: Lakew, Berhane
name: Woldeyohannes, Aemiro Bezabih
name: Fikere, Mulusew
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. List of 105 barley genotypes obtained from the ex-situ collection of the Ethiopian Biodiversity Institute (EBI), Ethiopian Institute of Agricultural Research (EIAR) and Universities with the region of origins and altitude ranges.
A Multistate Trial of an Early Surveillance Program for Autism Within General Practices in Australia
Creators: name: Barbaro, Josephine
name: Masi, A
name: Gilbert, Melissa
name: Nair, Radhika
name: Abdullahi, Ifrah
name: Descallar, J
name: Dissanayake, Cheryl
name: Eastwood, J
name: Hasan, I
name: Jalaludin, B
name: Karlov, L
name: Khan, F
name: Kohlhoff, J
name: Liaw, ST
name: Lingam, R
name: Diaz, A Mendoza
name: Ong, N
name: Tam, CWM
name: Unwin, Katy
name: Woolfenden, S
name: Eapen, V
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: The early detection of developmental conditions such as autism is vital to ensure children can access appropriate and timely evidence-based supports, services, and interventions. Children who have undetected developmental conditions early in life are more likely to develop later health, developmental, learning, and behavioral issues, which in turn can have a cumulative effect over the life course. Methods: The current protocol describes a multi-site, cluster randomized control trial comparing a developmental surveillance pathway for autism to usual care, using opportunistic visits to general practitioners (GPs). Units of randomization are GP clinics across two Australian states (New South Wales and Victoria), with thirty clinics within each state, each of which will aim to recruit approximately forty children aged between ~18- and 24-months, for a total of ~2,400 participants. Children will be randomized to two clusters; namely, an autism surveillance pathway (ASP) or surveillance as usual (SaU). The screening process for the ASP arm involves primary and secondary screenings for developmental concerns for autism, using both parent and GP reports and observations. Children in both arms who show signs of developmental concerns for autism will be offered a full developmental assessment by the research team at 24 months of age to determine the efficacy of developmental surveillance in successfully identifying children with autism. Trial Registration: The trial is registered with ANZCTR (ACTRN12619001200178) and reporting of the trial results will be according to recommendations in the CONSORT Statement.
COPOLYMERIZATION OF (p-VINYLPHENYL)CYCLOPROPYLMETHYLCINNAMATE WITH GLYCIDILMETHACRYLATE
Creators: name: Guliyev, Kazim Gafar
name: Aliyeva, Afat Mirza
name: Mamedli, Saida Bakhtiyar
name: Nurullayeva, Dilbar Rushan
name: Guliyev, Abasgulu Mamed
Publisher: name: European Chemical Bulletin
Year: 2016

description: The radical copolymerization of (p-vinylphenyl) cyclopropylmethylcinnamate with glycidilmethacrylate has been studied. New cyclopropane- and epoxycontaining photosensitive copolymers have been prepared. The constant values of relative activity of monomers have been determined and the parameters of Q-e on Alfrey and Price have been determined. The copolymerization constants of the given compound (r1) with glycidylmethacrylate (r2) calculated on Fineman-Ross method are: r1 = 1.05, r2 = 0.4 correspondingly; the parameters values Q and e: Q1  = 1.82, e1 = -0.79 correspondingly. The composition and structure of this copolymer has been established. The photochemical investigations of the synthesized copolymer have been carried out. It has been established that the structuring proceeds due to cyclopropane ring opening and epoxide groups and also double bond in cinnamate fragment.
description: European Chemical Bulletin, Vol 5, No 3 (2016): European Chemical Bulletin
Health Problems of Professional Ballet Dancers
Creators: name: Verulava, Tengiz
name: Tvalavadze, Ketevan
name: Jorbenadze, Revaz
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Ballet is a professional activity that places risky physical and psycho-emotional demands on the human body. The goal of this study was to evaluate health-related problems among ballet dancers. Within the qualitative study, in-depth interviews were conducted with ballet dancers at the State Ballet of Georgia. Participants' mean age was 23.4 ± 3.5 years, the average BMI - 21.2 ± 2.2. Dancers had spent 9.2 ± 7.4 years studying dancing professionally. On average, they spent 8.5 ± 5.8 hours in class and 16.2 ± 11.6 hours in rehearsal. Most injuries were related to ankle/feet (16%), knee (60%), and neck (13%). Common risk factors for incurring pain and injury included overuse (19%), previous injury (11%), and fatigue (11%). Of the injured dancers, 80% chose to seek medical attention. Mostly, they visited traumatologists (40%) and physiotherapists (30%). The biopsychosocial condition of ballet artists is affected by physical workload, high risk of injuries, as well as constant stress. The result suggests high prevalence and recurrence of dance injuries. Ankle/feet, knee and neck are especially risky topological areas for injuries as particularly big pressure is placed on the feet and ankle joints. The majority of respondents sought advice from medical specialists rather than family physicians. It is necessary to prevent injuries and stress through raising awareness. A team of professionals (family physician, orthopedist, psychologist, nutritionist, endocrinologist, physical therapist, nurse) is needed to prevent injuries. Family doctors should pay more attention to the promotion of a healthy lifestyle during the consultation with ballet dancers.
REMOVAL OF TITAN YELLOW DYE FROM AQUEOUS SOLUTION BY POLYANILINE/Fe3O4 NANOCOMPOSITE
Creators: name: Salem, Mohamed A.
name: Salem, Ibrahim A.
name: Hanfy, Mahmoud G.
name: Zaki, Ahmed B.
Publisher: name: European Chemical Bulletin
Year: 2016

description: The efficiency of polyaniline/Fe3O4 (PANI/Fe3O4) nanocomposite (NC) as an adsorbent was investigated in the removal of Titan yellow (TY) dye from aqueous solution.  The PANI/Fe3O4 was synthesized by polymerization of aniline in H2SO4 medium in the presence of Fe3O4 nanoparticles with ammonium persulfate as an oxidant.  The NC formed was characterized by SEM and FT-IR methods. The dye removal process was studied under various conditions and was found that the adsorption activity of the PANI/Fe3O4 NC  was greater than that of the bare PANI and Fe3O4 nanoparticles. Adsorption kinetics fitted with pseudo-first-order kinetic model.
description: European Chemical Bulletin, Vol 5, No 3 (2016): European Chemical Bulletin
Effect of anterior cruciate ligament rupture on physical activity, sports participation, patient-reported health outcomes, and physical function in young female athletes
Creators: name: Ezzat, Allison
name: Brussoni, M
name: Mâsse, LC
name: Emery, CA
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Background: Return to sports (RTS) is frequently considered an indicator of successful recovery after anterior cruciate ligament reconstruction (ACLR). However, despite the well-recognized health benefits of physical activity (PA), little is known about objectively measured PA in the 1 to 2 years after ACLR. Given that young female athletes have a high prevalence of ACLR and lower RTS rates as compared with their male counterparts, an in-depth examination of PA in this subgroup is warranted. Hypothesis: We hypothesized that female youth and young adults who have had ACLR in the previous 1 to 2 years would have less moderate or vigorous PA (MVPA) compared with healthy matched controls. We also hypothesized that the ACLR group would report lower levels of sports participation, patient-reported health outcomes, and physical function. Study Design: Cohort study; Level of evidence, 3. Methods: Participants included 51 female athletes with primary unilateral ACLR for a sports-related injury in the previous 1 to 2 years and 51 age- and sports-matched controls. Outcomes included objectively measured PA (GT3X accelerometers), previous and current sports participation and RTS, body mass index, Knee injury and Osteoarthritis Outcome Score (KOOS), triple single-leg hop, and one-leg rise. Mean within-pair differences with 95% CIs were used to assess differences between groups across all outcomes. Multivariable linear regression (clustered by pair) was used to examine whether the ACLR group had less MVPA than did the age- and sports-matched control group, adjusting for total wear time, age, time since injury, and body mass index. Results: Median age was 17.8 years (range, 14.6-22.6 years). There was no significant difference between groups in MVPA. However, the injury group had fewer mean minutes per day of vigorous PA (–1.22; 95% CI, −2.40 to −0.04), poorer KOOS values on all subscales, and shorter triple single-leg hop distance. In the injury group, 28 (55%) returned to sports, including 14 (27.5%) who returned at preinjury performance level. Across both groups, over one-third changed their most important sport, shifting toward an individual-based sport. Conclusion: At 1 to 2 years after ACLR, female athletes demonstrated no differences in combined MVPA and only a very small reduction in vigorous PA, yet they had higher levels of self-reported knee pain and symptoms, reduced knee function in sports, lower quality of life, and poorer objective knee function compared with matched controls.
Supplementary_table – Supplemental material for Analysis of Tumor Depth Invasion With Anti-Smoothelin Antibody in Equivocal Transurethral Resection of Urinary Bladder Tumor Surgical Specimens
Creators: name: Mihai, Ioana Maria
name: Gheorghe-Emilian Olteanu
name: Herman, Diana
name: Anderco, Denisa
name: Iacob, Mihaela
name: Nataras, Bianca
name: Cumpanas, Alin Adrian
name: Razvan Bardan
name: Dema, Alis
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110323 Surgery

description: Supplemental material, Supplementary_table for Analysis of Tumor Depth Invasion With Anti-Smoothelin Antibody in Equivocal Transurethral Resection of Urinary Bladder Tumor Surgical Specimens by Ioana Maria Mihai, Gheorghe-Emilian Olteanu, Diana Herman, Denisa Anderco, Mihaela Iacob, Bianca Nataras, Alin Adrian Cumpanas, Razvan Bardan and Alis Dema in International Journal of Surgical Pathology
title: Podcasts & punishment
title:  true crime podcasts and opinions on the death penalty in Canada
titleType: Subtitle
Creators: name: Piché, Sophie
Publisher: name: Mount Royal University
publisherIdentifier: https://ror.org/04evsam41
publisherIdentifierScheme: ROR
Year: 2022
Subjects: True crime
True crime podcasts
Death penalty
Capital punishment

description: True crime podcasts are very popular in Canada and across the world. Despite this, little research has been done on the genre and what its impact may be on Canadian listeners. Using data from a survey on 455 true crime podcast consumers in Canada, this study identifies common listener characteristics and participant support for the reinstatement of the death penalty. Relationships between high podcast consumption, participation in crime and justice activism, and support for the death penalty are explored, and opportunities for future research are discussed.