cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Failure analysis, modeling, and prediction for BlueGene/L
Creators: name: Liang, Yinglung
Publisher: name: No Publisher Supplied
Year: 2007

description: The growing computational and storage needs of scientific applications mandate the deployment of extreme-scale parallel machines, such as IBM's BlueGene/L, a 64K dual-core processor system. One of the challenges of designing and deploying such systems in a production setting is the need to take failure occurrences into account. Once the large scale system equipped with a failure predictability, the fault tolerance and resource management strategies of the system can be improved significantly, and its performance can be highly increased.This dissertation is based on the Reliability, Availability and Serviceabilit (RAS) events generated by IBM BlueGene/L over a period of 142 days. Using these logs, we performed failure analysis, modeling, and prediction. Filters are created to reveal the system failure behaviors, three preliminary models are identified for the failures, and finally, three failure predictors are established for the system. We heavily use data mining and time series analysis techniques for this dissertation. Our comprehensive evaluation demonstrates that our Bi-Modal Nearest Neighbor predictor greatly outperforms the other two (RIPPER and LIBSVM based), leadingto an F-measure of 70% and 50% for a 12-hour and 6-hour prediction window size.
Fidena (Leptofidena) morio
Creators: name: González, Christian R.
name: Elgueta, Mario
name: Krolow, Tiago K.
name: Henriques, Augusto L.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tabanidae
Fidena
Fidena morio

description: Fidena (Leptofidena) morio (Wulp, 1881)
Pangonia morio Wulp, 1881: 156–157.
Leptofidena beelzebul Kröber, 1930d: 223, fig. 6. Holotype. Female (MLUH), Argentina: Tucumán. Kröber, 1934: 245 (cat., Leptofidena); Barretto & Duret, 1954: 203 (redes.); Coscarón, 1967b: 105 (Argentina spp.); Fairchild, 1967a: 352 (tax., Kröber’s types, Leptofidena), 381 (fig. 14); Lessard, 2014: 227, 229 (cit.).
Holotype. Female (ZMAN). Type-locality: Argentina (without precise locality).
Distribution. Argentina: Provincias de Buenos Aires, Mendoza, Tucumán. Chile: Región de Coquimbo (Elqui, Huasco); Región de Los Ríos (Valdivia).
References. Ricardo, 1900: 172 (NHMUK spp., Diatomineura); Hunter, 1901: 134 (cat., Pangonia); Kertész, 1908: 170 (cat., Diatomineura (Diatomineura )); Brèthes, 1907: 284 (cat., Pangonia); Brèthes, 1910: 473 (redes., Erephopsis); Brèthes, 1921: 18 (com., Erephopsis); Kröber, 1933: 264–265 (redes., fig. 13); Kröber, 1934: 248 (cat.); Coscarón, 1967b: 108 (Argentina spp.); Fairchild, 1967b: 249 (Wulp’s type), 1971: 25 (cat.); Moucha, 1976: 39 (cat.); Bernardi, 1977: 261 (rev.); Iide, 1989: 268–272 (redes., figs. 1–17); Coscarón & González, 1991: 129 (Chile spp., figs. 63–64); Fairchild & Burger, 1994: 47 (cat.); Coscarón, 2001: 68 (redes., figs. 10D–L); Coscarón, 1998: 350 (list, dist.); Coscarón & Papavero, 2009a: 62 (male, female, figs. 34A–I); Coscarón & Papavero, 2009b: 45 (cat.); Lessard, 2014: 227, 229, 238 (rev.).
description: Published as part of González, Christian R., Elgueta, Mario, Krolow, Tiago K. & Henriques, Augusto L., 2022, Catalog of the horse-flies (Diptera: Tabanidae) of Chile, pp. 201-257 in Zootaxa 5091 (2) on page 217, DOI: 10.11646/zootaxa.5091.2.1, http://zenodo.org/record/5843635
Dewey Decimal Classification(DDC)
Creators: name: Sarkar, Smriti
name: West Bengal State University
Publisher: name: Zenodo
Year: 2024
Subjects: Library Science
DDC
Dewey Decimal Classification
16 th edition of DDC
Phoenix Schedule
DDC Index
Relative Index

description: The Dewey Decimal Classification (DDC) is a system for organizing knowledge and is used in many libraries around the world. It's the most widely used classification system in the world.

1. 16 th edition of Dewey Decimal Classification is  called “Phoenix Schedule”.

2. Dewey Decimal Classification Index is  called “Relative Index”.
Biotech Patent Eligibility: A New Hope
Creators: Kim, Eugene
Publisher: name: Columbia University
Year: 2017
Subjects: subject: Law
subject: FOS: Law
subject: Patent laws and legislation
subject: Biotechnology industries
subject: Liver cells
subject: Biotechnology--Law and legislation

description: The practical effect of the Supreme Court’s decisions in Mayo Collaborative Services v. Prometheus Laboratories, Inc. and Alice Corporation Pty. v. CLS Bank International has been to deny patent eligibility to innovative patent applications and patents, particularly in the fields of biotechnology and computer software. On July 5, 2016, the Federal Circuit in Rapid Litigation Management Ltd. v. CellzDirect, Inc. ruled that the claimed methods of cryopreserving hepatocyte cells are patent eligible under 35 U.S.C. § 101 because they are not directed to a natural phenomenon. The patentees discovered that some cells in a hepatocyte pool could survive multiple freeze-thaw cycles. The claims recite a method of producing a preparation of hepatocytes that can be frozen and thawed at least twice. The method steps include freezing and thawing a sample of hepatocytes, performing density fractionation to separate viable and non-viable cells, recovering the viable hepatocytes, and refreezing the recovered hepatocytes.The Federal Circuit decided that, although dependent on a natural phenomenon, the inventors’ claims were a patent eligible application of their natural discovery. As a result, the court may have opened up a new avenue for patent seekers to circumvent the restrictive eligibility requirements established by the Supreme Court. This Note provides a brief history of patent eligibility doctrine and the cases leading up to the decision in CellzDirect. It next analyzes the CellzDirect decision and its possible interpretations. Finally, it argues that this case represents an effort by the Federal Circuit to limit the Supreme Court’s extreme anti-patent position in Mayo and Alice by cabining the eligibility restrictions to diagnostic discoveries.
Asymptotic behavior and Denjoy-Wolff theorems for Hilbert metric nonexpansive maps
Creators: name: Lins, Brian C.
Publisher: name: No Publisher Supplied
Year: 2007

description: We study the asymptotic behavior of fixed point free Hilbert metric nonexpansive maps on bounded convex domains.  For such maps, we prove that the omega limit sets are contained in a convex subset of the boundary when the domain is either polyhedral or two dimensional.  Similar results are obtained for several classes of positive operators defined on closed cones, including linear maps, affine linear maps, max-min operators, and reproduction-decimation operators.  We discuss the relationship between these results and other Denjoy-Wolff type theorems.  In particular, we investigate the interaction of nonexpansive maps with the horofunction boundary in the Hilbert geometry and in finite dimensional normed spaces.
A study on adaptive stimulation of the basal ganglia as a treatment for Parkinsonism
Creators: name: Leondopulos, Stathis S.
Publisher: name: No Publisher Supplied
Year: 2007

description: The purpose of this dissertation is to design an automated system for the modification of Deep Brain Stimulation (DBS) parameters based on specific identifiers in the neuronal response of Parkinsonian patients undergoing DBS treatment. The neural response patterns are obtained from an artificial neural network consisting of dynamic neuron and synapse components and programmed to exhibit a response to pulse stimuli that resembles the activity in the subthalamic nucleus of Parkinsonian patients undergoing DBS treatment. Moreover, using pulse stimuli of varying specification, a band-pass filtered response of the network is subjected to a set of signal processing techniques including Linear Predictive Coding (LPC), Autoregressive Moving Average (ARMA) modeling, Discrete Fourier Transform (DFT), moments and higher order statistics, producing a set of results or features. Then, each feature is evaluated to determine the effectiveness, in terms of error probability, of discerning between different neuronal responses to pulse stimuli. Furthermore, a digital circuit is designed at the transistor level for computing the 1st LPC coefficient of recorded neural data and also autonomously regulating the specifications of the stimulus waveform based on the value of the computed coefficient. Also, the circuit design is optimized using a pipeline to reduce dynamic power dissipation. Moreover, it is suggested that a similar design may be useful in automating the administration of DBS as a treatment for Parkinsonism with only a minimal additional power demand.
Osca Walker 1850
Creators: name: González, Christian R.
name: Elgueta, Mario
name: Krolow, Tiago K.
name: Henriques, Augusto L.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tabanidae
Osca

description: Genus Osca Walker, 1850: 10
Type-species: Pangonia depressa Macquart, 1838a (subs. des., Coquillett, 1910: 581) = Osca lata (Guérin-Méneville, 1835).
Diatomineura Rondani, 1863: 84. Type-species: Pangonia depressa Macquart, 1838a (subs. des., Coquillett, 1910: 532) = Osca lata (Guérin-Ménéville, 1835).
Bombomimetes Enderlein, 1922: 340 (in key). Type-species: Pangonia rufoaurea Phillippi, 1865: 709 (orig. des.) = Osca rufa (Macquart, 1838a).
Calliosca Enderlein, 1925: 405. Type-species: Calliosca schoenemanni Enderlein, 1925: 405 (orig. des.) = Osca varia (Walker, 1848).
References. Brèthes, 1914: 59 (com.); Kröber, 1930b: 157 (key); Borgmeier, 1933: 298 (tax.); Fraga, 1938b: 67 (key to species); Fraga, 1938c: 150 (in key); Stuardo, 1946: 68 (cat.); Coscarón & Wilkerson, 1985: 279–281 (key to species, Scaptia); Coscarón & Papavero, 1993: 18 (in key, Scaptia); Fairchild & Burger, 1994: 34 (cat., Scaptia); González et al., 1997: 154 (dist., Scaptia); Coscarón & Papavero, 2009a: 9 (in key, Scaptia); Coscarón & Papavero, 2009b: 46 (cat., Scaptia); Lessard, 2014: 211, 219 (rev., reval.).
description: Published as part of González, Christian R., Elgueta, Mario, Krolow, Tiago K. & Henriques, Augusto L., 2022, Catalog of the horse-flies (Diptera: Tabanidae) of Chile, pp. 201-257 in Zootaxa 5091 (2) on page 217, DOI: 10.11646/zootaxa.5091.2.1, http://zenodo.org/record/5843635
MOESM1 of Insecticide-treated net effectiveness at preventing Plasmodium falciparum infection varies by age and season
Creators: name: Buchwald, Andrea
name: Coalson, Jenna
name: Cohee, Lauren
name: Walldorf, Jenny
name: Chimbiya, Nelson
name: Bauleni, Andy
name: Kondwani Nkanaunena
name: Ngwira, Andrew
name: Sorkin, John
name: Mathanga, Don
name: Taylor, Terrie
name: Laufer, Miriam
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Predictors of infection (qPCR positive) stratified by net use (n=17,538). Table S2. Adjusted odds ratios for association between covariates and infection (microscopy positive) using mixed models. Table S3. Crude and adjusted estimates of ln (microscopy positive prevalence) difference associated with covariates.
Osca abdominosa
Creators: name: González, Christian R.
name: Elgueta, Mario
name: Krolow, Tiago K.
name: Henriques, Augusto L.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tabanidae
Osca
Osca abdominosa

description: Osca abdominosa (Philip, 1968b)
Scaptia abdominosa Philip, 1968b: 115–116, fig. 3a.
Holotype. Female (CAS). Type-locality: Chile, Coquimbo, La Serena.
Distribution. Chile: Región de Coquimbo (Elqui).
References. Moucha, 1976: 26 (cat., Scaptia (Scaptia )); Arnaud, 1985: 92 (Philip’s species); Coscarón & Wilkerson, 1985: 281 (? Scaptia (Scaptia )); Coscarón & González, 1991: 128 (Chile spp., Scaptia (Scaptia )); Fairchild & Burger, 1994: 34 (cat., Scaptia (Scaptia )); Coscarón, 1998: 349 (list, dist.); Coscarón & Papavero 2009b: 50 (cat.; Scaptia (Scaptia )); Lessard, 2014: 238 (rev.).
description: Published as part of González, Christian R., Elgueta, Mario, Krolow, Tiago K. & Henriques, Augusto L., 2022, Catalog of the horse-flies (Diptera: Tabanidae) of Chile, pp. 201-257 in Zootaxa 5091 (2) on page 217, DOI: 10.11646/zootaxa.5091.2.1, http://zenodo.org/record/5843635
Mobile music technology, communication isolation and community building: an analysis of college students' use of digital entertainment
Creators: name: Lever, Katie Marie
Publisher: name: No Publisher Supplied
Year: 2007

description: This dissertation explores the social implications of MP3 use, and particularly focuses on the ways in which these technologies have the major effect of isolating users and the ways in which they facilitate sharing practices and social interaction.This dissertation asks:  why do students adopt MP3 devices, what are the social implications of use, what goals do students have in mind when using them, and do other factors such as personality, perceived technological aptitude and gender play a role in how individuals adopt and use these technologies?A total of 43 students participated in three focus groups which were conducted at various points in February and March of 2006.  A survey of 200 students was conducted during the month of April of 2007.  Based on these data, it appears that social influence, in addition to pure personal utility, play a role in adoption decisions.  Dimensions affecting consumption behavior are the environmental isolation and personal entertainment factors which can be provided by the mobile players.  However, a substantial minority of students also use the device not to isolate themselves but rather, to engage with other students.  Additionally, the research confirmed prior studies indicating that males perceive themselves as having higher levels of proficiency in MP3 use and operation, but also more generally with technologies. The personality dimension of sociability was found to play a role in whether or not individuals physically share their devices with others.  In terms of behavior and management of access to others, 87% of respondents indicated that they had, through their use, ignored someone else.  A statistical relationship was also found to exist between the variables of dependency and having engaged in socially isolating behaviors.  In terms of the theoretical implications of this research, it seems that Apparatgeist Theory (Katz &amp;amp; Aakhus, 2002), Domestication Theory (Silverstone &amp;amp; Haddon, 1996), and Uses and Gratifications (Katz et al., 1974) can all be applied to the MP3 dynamic.  In sum, this research found that students use their music technologies not only for solitary listening activities, but for sharing interactions as well.
Additional file 3: Figure S2. of Improved genome sequencing using an engineered transposase
Creators: name: Amirali Kia
name: Gloeckner, Christian
name: Osothprarop, Trina
name: Gormley, Niall
name: Bomati, Erin
name: Stephenson, Michelle
name: Goryshin, Igor
name: He, Molly
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: DNA binding stability of Tn5 vs. Tn5-059. While heating at 74.2 °C is required for Tn5 to dissociate from tagmented DNA to allow following PCR amplification of DNA to reach the level of positive control, the temperature is elevated to 76.6 °C for Tn5-059 to do the same. The negative control is tagmentation without PCR amplification. The positive control is tagmentation followed by complete removal of transposase by Zymo cleaning to allow PCR amplification. (PDF 81 kb)
Mechanisms of Tobacco-Induced Retinal Neovascularization
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This grant is a first step toward a novel therapy for the tobacco-related disease of age-related macular degeneration (AMD), the major cause of blindness in the United States. AMD is a disease of the retina, which involves the growth of abnormal blood vessels. These abnormal vessels can leak fluid or blood, which can disturb visual acuity or even cause scarring and blindness. Notably, the major preventable risk factor for AMD is smoking. Those who smoke are at a greater risk for developing this eye disease. We believe that the nicotine in tobacco is primarily responsible for the abnormal vessel growth. In this proposal, we intend to determine if nicotine accelerates the formation of abnormal vessels in the eye, and we plan to test a new therapy.

 This grant builds on our previous work (funded by the TRDRP) revealing that nicotine triggers abnormal vessel growth. This surprising effect of nicotine provides a new paradigm for tobacco-related diseases such as cancer, atherosclerosis, and AMD. We have shown (in animal models) that nicotine can accelerate tumor growth by stimulating the growth of tumor vessels. We found that the effect of second hand smoke to promote tumor angiogenesis and tumor growth can be blocked by mecamylamine, an antagonist of nicotine-induced vessel growth.

 In this study, we will use a mouse model of AMD to determine how nicotine stimulates abnormal vessel growth. We will look for nicotine receptors on the blood vessels of the eye. Subsequently, we will determine if second hand smoke and/or nicotine can stimulate these receptors to accelerate the growth of abnormal vessels and/or if nicotine influences the leakiness of these vessels. We will determine how much nicotine gets into the eye, and will determine the effects of intra-ocular nicotine on proteins involved in vessel growth. Finally, we will determine if the growth and/or leakiness of abnormal vessels in the eye can be inhibited by the drug mecamylamine (which blocks nicotine receptors) and/or other methods to block nicotine receptors in the eye. These studies are intended to provide new insights into a major tobacco-related disease, and to lead directly toward a new approach to treating AMD.
Dacalana penicilligera
Creators: name: Bhowmik, Suman
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Lycaenidae
Dacalana
Dacalana penicilligera

description: 28. Dacalana penicilligera (de Niceville, 1890) (Double-tufted Royal)
Remarks. A single individual was sighted from Panisagar till 03.v.2016, inside a forest patch (24°17’6” N & 92°9’20” E, ca. 61 m above msl.) near roadsides. Later several observations were made in Rowa Wildlife Sanctuary. This species is rare throughout the state, but it can be seen from March onwards in the present locality.
Current known distribution. Bangladesh, Myanmar, India (West Bengal to Northeast India) (Van Gasse 2013; Varshney & Smetacek 2015).
description: Published as part of Bhowmik, Suman, 2021, Fifty-one new additions to the butterfly (Lepidoptera: Rhopalocera) fauna of Tripura, North-east India, pp. 35-60 in Revista Chilena de Entomología (Rev. Chil. Entomol.) (Rev. Chil. Entomol.) 47 (1) on page 49, DOI: 10.35249/rche.47.1.21.04, http://zenodo.org/record/10950112
Acidity and proton affinity measurement of cytosine by multiple methods in the gas phase
Creators: name: Li, Tingting
Publisher: name: No Publisher Supplied
Year: 2007

description: The measurement of the intrinsic acidity of nucleic bases is essential for understanding the fundamental properties in biological systems. The Hydrogen bonding is critical to DNA stability and reactivity of oligonucleotides. The strength of hydrogen bonding can be gauged by the intrinsic acidity of the donor NH groups and the intrinsic basicity of acceptor atoms. Acidity is also indicative of the leaving group ability of a nucleobase in deglycosylation processes. In this dissertation, we examine the gas phase acidity and proton affinity of cytosine using Fourior transform mass spectrometry (FTMS), liquid chromatography mass spectrometry (LCMS) and ab initio calculations at B3LYP/6-31+G*. The experimental gas phase acidities and proton affinities were established using bracketing method, equilibrium method and Cooks kinetic method. Finally, we discuss the tautomer problem and deuterated experiments and the possible mechanism of the base excision repair by TDG enzyme.
Putting Directors’ Money Where Their Mouths Are: A New Approach to Improving Corporate Takeover Dynamics
Creators: Shilon, Nitzan
Publisher: name: Columbia University
Year: 2017
Subjects: subject: Law
subject: FOS: Law
subject: Consolidation and merger of corporations
subject: Boards of directors
subject: Judicial review
subject: Law reform

description: This paper aims to improve shareholder protection from underpriced bids in takeover situations. Target boards, as stewards of the corporation who typically possess superior information about the desirability of unsolicited bids, can be expected to protect their shareholders from such bids. Unfortunately, because they have a conflict of interest with their shareholders in takeover situations, they tend to reject hostile bids to an excessive degree. Moreover, the current Delaware doctrine is ineffective in monitoring boards’ responses to takeovers, largely because boards might use selective inside information to which the courts lack access and because their judgments are backed by subjective, hard-to-attack legal and financial expert opinions which courts are ill-equipped to challenge. To rectify the problems of courts’ and shareholders’ inferior information as well as boards’ skewed incentives, I propose an arrangement in which target boards wishing to veto nonstructurally coercive takeover bids would be encouraged to demonstrate their opposition by committing to buy, if the bid fails, and hold for a specified period of time a certain amount of target stock at the bid price. The directors would be incentivized to follow the arrangement because it would require courts, in a potential fiduciary duties lawsuit, to give directors’ commitments significant weight when evaluating their defense that they rejected the bid to protect their shareholders. Adopting the proposed arrangement can significantly address important problems in corporate takeovers that have long claimed the attention of corporate law scholars and financial economists. In particular, inducing target boards to credibly transmit their genuine bottom-line understanding about the desirability of a bid would offset the courts’ inability to review the directors’ decision effectively. Imposing personal costs that the directors would uniquely incur if they wish to reject hostile bids would counteract the directors’ ex-post incentive to reject hostile bids excessively. Increasing the directors’ cost of a takeover attempt would improve market discipline and motivate the directors to increase firm value and reduce agency costs. Finally, favoring firms with high long-term value would protect them from myopic bidders and alleviate their unrelenting pressure to meet quarterly earnings expectations. For these reasons, the proposed arrangement could greatly improve corporate takeover dynamics.
Osca albithorax
Creators: name: González, Christian R.
name: Elgueta, Mario
name: Krolow, Tiago K.
name: Henriques, Augusto L.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tabanidae
Osca
Osca albithorax

description: Osca albithorax (Macquart, 1838a)
Pangonia albithorax Macquart, 1838a: 107–108; Macquart, 1838b: 111–112.
Lectotype. Female (MNHN). Type-locality: “ Chile ” (without precise locality).
Distribution. Chile: Región de Coquimbo (Elqui); Región de Valparaíso (Aconcagua, Los Andes); Región Metropolitana (Cordillera, Santiago); Región del Maule (Linares).
References. Macquart, 1837: 431 (com.); Walker, 1848: 143 (list, Pangonia); Blanchard, 1854: 388 (redes., Pangonia); Blanchard in Gay, 1854: Dípteros, pl. 1, fig. 7); Walker, 1854: 125 (com., Pangonia); Philippi, 1865: 707 (list, Pangonia); Schiner, 1868: 101 (com., Pangonia); Kertész, 1900: 15 (cat., Pangonia); Ricardo, 1900: 172 (NHMUK spp., Diatomineura); Hunter, 1901: 133 (cat., Pangonia); Porter, 1902: 244 (Chile spp., Pangonia); Kertész, 1908: 168 (cat., Diatomineura (Diatomineura )); Surcouf, 1921: 130 (dist., Diatomineura); Enderlein, 1925: 278 (com., Parosca); Kröber, 1930b: 163 (in key), 167 (redes., as albithorax Ricardo, error), 1930f: 124 (in key), 125 (redes.); Kröber, 1934: 237 (cat.); Fraga, 1938b: 67 (in key), 67–68 (dist., redes., pl. 6, fig. 1); Stuardo, 1946: 68 (cat.); Fairchild, 1956: 10 (com., Scaptia (Scaptia )); Philip, 1968a: 9 (tax., designation of lectotype, Scaptia); Fairchild, 1971: 14 (cat., Scaptia (Scaptia )); Pino et al., 1973: 211 (ecol.); Pino, 1975a: 182 (com., Scaptia (Scaptia )); Moucha, 1976: 26 (cat., Scaptia (Scaptia )); Coscarón & Wilkerson, 1985: 282 (rev., Scaptia (Scaptia )); Coscarón & González, 1991: 128 (Chile spp., Scaptia (Scaptia )); Fairchild & Burger, 1994: 34 (cat., Scaptia (Scaptia )); Coscarón, 1998: 349 (list, dist.); Coscarón & Papavero 2009b: 50 (cat., Scaptia (Scaptia )); Lessard, 2014: 225, 238 (rev.).
description: Published as part of González, Christian R., Elgueta, Mario, Krolow, Tiago K. & Henriques, Augusto L., 2022, Catalog of the horse-flies (Diptera: Tabanidae) of Chile, pp. 201-257 in Zootaxa 5091 (2) on pages 217-218, DOI: 10.11646/zootaxa.5091.2.1, http://zenodo.org/record/5843635
Nicotine Disrupts PTHrP-Driven Paracrine Signaling Globally
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is the single major cause of chronic fibrosis affecting lungs, heart, kidney, and gums in the United States. Chronic fibrosis is associated with long-term ill health and it contributes to hundreds of thousands of premature deaths each year. Further, although the prevalence of smoking during pregnancy is decreasing, an unacceptably large percentage of women still smoke while pregnant. The mechanism(s) underlying predisposition to fibrosis in different organs in response to smoke/nicotine exposure either before or after birth is (are) poorly understood. However, there is now strong evidence to support that a break-down in cell-cell cross talk, i.e., how cells talk to each other molecularly, in different organs may be playing a crucial role in fibrosis in various organs. We have identified a specific protein that is essential in maintaining this cell-cell communication in the lung under normal conditions of good health. If, however, the levels of this protein go down, it sets the stage for lung fibrosis. Indeed we have seen that nicotine exposure does decrease the levels of this protein in the lung significantly. Further, maintaining normal levels of this protein in the lung during exposure to conditions that would otherwise cause lung fibrosis, e.g., exposure to nicotine, a normal lung health was maintained, and fibrosis could be prevented. This is a huge step in designing treatment strategies against lung fibrosis. However, we feel that the mechanism, which helps in maintaining normal lung health, is not restricted only to the lung, but is likely to a fundamental mechanism in many other organs systems as well. Therefore, now we propose to look at whether nicotine exposure also adversely affects the levels of the relevant protein essential for cell-cell communication in other organs, such as the kidney, liver, brain, and long bones, as well. Incidentally, all of these organs are already known to express this protein, but how exposure to nicotine affects the levels of this protein it is not known. The proposed studies are likely to provide us a novel understanding that for the first time might open up the possibility of preventing nicotine-induced organ damage in almost all organ systems simultaneously. In fact, we will look at not only the prevention but also the possibility of reversibility of nicotine-induced injury in various organs. Our hypothesis and proposed studies will unravel the molecular mechanisms of fibrosis in general, enabling us to better understand, prevent, treat, or even reverse this process through more rationale and focussed interventions. In line with Tobacco-Related Disease Research Program goals, this has an enormous potential of opening up novel interventional strategies to tackle not only the nicotine-induced fibrosis, but also all chronic diseases characterized by fibrosis in general.
Doping polythiophene derivatives with tridecafluoro-1,1,2,2-tetrahydrooctyl trichlorosilane vapor
Creators: name: Kao, Chi-Yueh
Publisher: name: No Publisher Supplied
Year: 2007

description: A conducting polymer system of derivatives of polythiophene has been achieved by doping with tridecafluoro-1,1,2,2-tetrahydrooctyl trichlorosilane (TTT). After doping, conductivities of both polymers, poly(3-hexylthiophene) (P3HT) and poly[2,5-bis(3-decabutylthiophene-2-yl)thieno(2,3-b)thiophenes] (PBTTT), increased by over five orders of magnitude. We observed non-homogeneous swelling of the polymer film using atomic force microsopy and other microscopic methods. We also showed that under certain conditions the doping was reversible. Based on an analysis of the UV-Vis spectra and other data, it seems that the dedoping was almost complete. We demonstrated that dedoping could be efficiently facilitated by exposing the films to light. We also observed large protrusions on the surface of some samples that could be explained as a mixture of polymer and organic solvent. These surface features do not contribute to the conductivity.
Privacy in emerging wireless networks
Creators: name: Kamat, Pandurang
Publisher: name: No Publisher Supplied
Year: 2007

description: Ad hoc wireless networks have emerged as a solution to providing ubiquitous, on-demand connectivity without the need for significant infrastructure deployment. In this thesis we address the privacy problems in two types of emerging wireless ad hoc networks, namely sensor and vehicular networks.Although the content of sensor messages describing ``events of interest'' may be encrypted to provide confidentiality, the context surrounding these events may also be sensitive and therefore should be protected from eavesdroppers. The source-location privacy problem occurs in sensor networks when adversaries use RF localizationtechniques to perform hop-by-hop traceback of messages to the source sensor's location. Our work provides a formal model for this problemand examines the privacy characteristics of different sensor routing protocols. In order to provide efficient and private sensor communications, we devise new techniques to enhance source-location privacy that augment these routing protocols.Similarly, an adversary armed with knowledge of the network deployment, routing algorithms, and the data sink location can infer the temporal patterns and track the spatio-temporal evolution of a sensed event, by monitoring the packet arrivals at the sink. We introduce the temporal privacy problem for delay-tolerant sensornetworks, provide an information theoretic formulation and propose adaptive buffering to obfuscate temporal information from the adversary.Sensor networks are also characterized by distinctive traffic patterns, wherein traffic mostly exists when events of interests occur. Due to the direct correlation between the type of event andsize of data generated by it, an adversary observing a traffic burst can infer information about the type of event simply from the observed message size. We formulate this traffic privacy problem in terms of information entropy, present a quantifiable means to measure traffic privacy and propose solutions to enhance it.Vehicular ad hoc networks represent a promising new communication paradigm that can facilitate many new forms of automotive applications. We present a robust and efficient security and privacyframework, for such networks, that uses identity-based cryptography. We show that our framework provides authentication, confidentiality, non-repudiation and message-integrity. Further, it supports scalable, user-customizable privacy through short-lived,unforgeable, pseudonyms.
Exploring GPX2 as a Therapeutic Target in Colorectal Cancer: From Radiotherapy Sensitivity to Chemotherapy Response and Beyond
Creators: name: Vukelic, Natalia
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 321105
subject: Chemotherapy
classificationCode: 321110
subject: Radiation therapy
classificationCode: 321109
subject: Predictive and prognostic markers
classificationCode: 321102
subject: Cancer diagnosis
classificationCode: 321101
subject: Cancer cell biology

description: Submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Cancer Medicine, La Trobe University, Victoria, Australia.
Muiti-layer optimization in wireless ad hoc networks
Creators: name: Wang Li, Xiangfang
Publisher: name: No Publisher Supplied
Year: 2007

description: The growing prevalence of wireless ad hoc networks calls for an innovative design to support Quality of Service (QoS) while maintaining high energy efficiency and bandwidth efficiency. In this dissertation, a multi-layer optimization approach is developed in view of benefits and necessities of sharing information among different layers. Specifically, given the traffic demands with QoS requirements, how to jointly design physical, MAC and network layers to optimize the network performance is considered in this dissertation.Firstly, a joint power control and maximally disjoint multipath routing scheme is proposed for QoS provisioning of end-to-end traffic with minimum rate constraint. A framework of power control with QoS constraints is introduced and both centralized and distributed solutions are derived. It is demonstrated by simulations that the proposed scheme provides high energy efficiency and the prolonged network lifetime, as well as robustness when augmented with a dynamic traffic monitoring and switching mechanism.In order to fulfill the QoS requirement at the link layer, TD/CDMA has been chosen as the MAC scheme due to its support for a high network throughput in a multihop environment. The multi-link versions of proportional fair and throughput optimal scheduling algorithms are proposed for multihop wireless ad hoc networks. In addition, a generic token counter mechanism is employed to satisfy the minimum and maximum rate requirements. Approximative algorithms are suggested to reduce the computational complexity. In networks that lack centralized control, distributed scheduling algorithms are derived and fully distributed implementations are provided. Simulation results demonstrate the effectiveness of the proposed schemes.In order to further improve bandwidth efficiency, cognitive radio is considered for more efficient spatial and temporal spectrum sharing. Specifically, we consider the scenario where a cognitive radio ad hoc network is formed by low power personal/portable devices operating simultaneously in the same frequency band along with a legacy system. A power control problem is formulated to maximize the energy efficiency of the ad hoc network, as well as to guarantee QoS for both legacy network users and ad hoc network users. The results show that cognitive radio greatly improves bandwidth efficiency of wireless ad hoc networks.
Social Smoking within College Drinking Environments
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Almost 1 in 8 college students initiate smoking while in college (Everett and Huston, 1999; Wechsler et al., 1998; Wetter, et al., 2004) and nearly 15% transition from non-daily to a daily smoking (Wetter et al., 2004). In a recent study of college students, 86.4% of occasional smokers reported a smoking episode while drinking alcohol (McKee et al., 2004). While a relationship between smoking and drinking among daily smokers is generally established, there have been fewer studies investigating this relationship among non-daily smokers or experimenters (individuals who have smoked fewer than 100 cigarettes in a lifetime). Of great concern is the fact that many non-daily smokers may progress to daily smoking. While the association of social smoking in drinking situations is clear, there has been little theoretical work on the mechanisms behind this association. Generally, research focusing on young smokers has focused on the co-morbidity of alcohol and tobacco use, and not on their proximal, concurrent use. A theoretical model that includes social, personal and environmental factors believed to be instrumental in facilitating social smoking in drinking contexts for college students is proposed. We are proposing two surveys to test this theoretical model. One survey will be an innovative late-night field survey that will sample whole groups of students around locations where drinking and smoking are occurring (i.e., bars, off-campus parties, on-campus). The other will be a random, internet-based survey of students attending a large, public university in Southern California. The results of these surveys will hopefully lead to the development of programs or activities designed to inhibit progression to daily smoking in this population of social smokers.
Ablepharus persicus Nikolsky 1905
Creators: name: Ananjeva, Natalia B.
name: Milto, Konstantin D.
name: Barabanov, Andrei V.
name: Golynsky, Evgeny A.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Scincidae
Ablepharus
Ablepharus persicus

description: Ablepharus persicus NIKOLSKY (“1905” 1907: 283)
Holotype:
ZISP 10342, “Deh-i-Mulla (Schachrud)” [Dehmolla, Semnan Province, Iran, 36.27 N 54.76 E]. Leg: N. A. Zarudny, 17.X.1903.
Present name: Ablepharus pannonicus Lichtenstein, 1823 fide Anderson (1999).
description: Published as part of Ananjeva, Natalia B., Milto, Konstantin D., Barabanov, Andrei V. & Golynsky, Evgeny A., 2020, An annotated type catalogue of amphibians and reptiles collected by Nikolay A Zarudny in Iran and Middle Asia, pp. 101-128 in Zootaxa 4722 (2) on page 119, DOI: 10.11646/zootaxa.4722.2.1, http://zenodo.org/record/3605815
In vivo tissue-level thresholds for spinal cord injury
Creators: name: Maikos, Jason
Publisher: name: No Publisher Supplied
Year: 2007

description: Primary damage to the blood-spinal cord barrier (BSCB) is a nearly universal consequence of spinal cord injury that contributes significantly to the overall pathology.  The in vivo tissue-level thresholds for mechanical disruption of the BSCB were identified by comparing the results of spinal cord contusions produced with weight drop injury to a finite element analysis (FEA) of the experimental model.  The extent and severity of primary, physical disruption of the BSCB was quantified in adult rats five minutes after graded trauma induced with the Impactor weight drop model of spinal cord contusion. The volume of extravasation of three markers of distinct size -- fluorescently labeled hydrazide (~730Da), fluorescently labeled bovine serum albumin (~70kDa), and immunohistochemically labeled red blood cells (~5µm) was evaluated in both the gray and white matter. Extravasation volumes increased with increasing drop height and decreasing species size, and were greater in gray matter than in white matter. A three-dimensional finite element analysis of the weight drop model was performed and validated with the in vivo experimental peak displacement of the spinal cord at two loading conditions.  The peak compression of the model was within ten percent of the experimental results.  A parametric analysis revealed that the model was most sensitive to changes in the viscoelastic properties of the spinal cord.  The finite element model provided temporal and spatial profiles of mechanical parameters that were used to identify tissue-level thresholds for BSCB injury using logistic regression analysis.  Thirteen mechanical parameters, including measures of stress, strain, and strain rate were investigated as predictors of BSCB injury.  Maximum principal strain (LEP) was considered the best predictor of injury in the gray matter, while von Mises strain (LEVM) was the best predictor of injury in the white matter, although the LEVM thresholds for white matter included relatively substantial error compared to the thresholds for gray matter. The results can be used to improve means and measures of preventing spinal cord injury in humans, define loading conditions for in vitro models of injury, and design new experimental models that produce specific patterns of injury.
Regulation of the PIS1-encoded phosphatiduylinositol synthase by zinc, and purification and characterization of the N-ethylmaleimide-sensitive Mg2+ dependent phosphatidate phosphatase
Creators: name: Han, Seung-Hee
Publisher: name: No Publisher Supplied
Year: 2007

description: In the yeast Saccharomyces cerevisiae, the mineral zinc is essential for growth and metabolism.  The effects of zinc depletion on the regulation of the PIS1-encoded phosphatidylinositol synthase were examined.  Phosphatidylinositol synthase activity increased when zinc was depleted from the growth medium.  Analysis of a zrt1D zrt2D mutant defective in plasma membrane zinc transport indicated that the cytoplasmic levels of zinc were responsible for the regulation of phosphatidylinositol synthase.  PIS1 mRNA, its encoded protein Pis1p, and the b-galactosidase activity driven by the PPIS1-lacZ reporter gene were elevated in zinc-depleted cells.  This indicated that the increase in phosphatidylinositol synthase activity was due to a transcriptional mechanism.  The regulation of PIS1 gene expression by zinc depletion was mediated by the zinc-regulated transcription factor Zap1p.  This work advances understanding of phospholipid synthesis regulation by zinc and the transcription control of the PIS1 gene.Mg2+-dependent phosphatidate phosphatase catalyzes the dephosphorylation of phosphatidate to synthesize diacylglycerol and inorganic phosphate.  There are at least two genes that encode Mg2+-dependent phosphatidate phosphatase enzymes in yeast.  The PAH1 gene encodes an enzyme that is insensitive to N-ethylmaleimide whereas the gene that encodes the N-ethylmaleimide-sensitive enzyme has yet to be identified.  The aim of this work was to purify and characterize the N-ethylmaleimide-sensitive Mg2+-dependent phosphatidate phosphatase.  To purify the enzyme, a pah1D dpp1D lpp1D triple mutant that is devoid of all known phosphatidate phosphatase enzymes was used.  The Mg2+-dependent phosphatidate phosphatase was extracted from the membrane fraction using 1 M NaCl.  The salt extracted enzyme was then purified by chromatography with phosphocellulose, Mono Q and Superose 6. The enzyme was enriched 2,250 fold by this procedure.  The basic enzymological properties of the purified Mg2+-dependent phosphatidate phosphatase were examined.  The enzyme had a pH optimum from 7 to 7.5, and was dependent on Mg2+ ions for activity.  The enzyme activity followed surface dilution kinetics using Triton X-100-phosphatidate mixed micelles.  The enzyme was inhibited by N-ethylmaleimide, phenylglyoxal and propranolol.  In addition, the enzyme activity was regulated by nucleotides, sphingolipids and phospholipids.  These studies provide information on the mode of action of this important enzyme in lipid metabolism.
NOVEL APPROACHES TO LUNG CANCER RESEARCH
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the most common cause of cancer-related death in the United States, and the high mortality reflects the invasive nature of the disease and its resistance to all current treatment modalities. Efforts to develop effective lung cancer prevention and treatment strategies have stimulated a strong interest in understanding the biology of lung neoplasia. Scientists now appreciate that the tumor microenvironment plays a critical role in lung cancer development and the clinical responses to radiotherapy and chemotherapy. It is known that tumors frequently evolve under conditions of abnormally low oxygen and nutrient supplies due to limited blood flow. Importantly, these stressed tumor cells are frequently less responsive to all currently available cancer therapies. A pressing need therefore exists for improved model systems, which allow scientists to probe the inner workings of lung cancer cells, such as variations in the supplies of oxygen and nutrients needed for tumor growth, and to develop therapeutic strategies targeting this highly resistant group of tumor cells.

 Our hypothesis is that development and application of three-dimensional culture systems of human lung cancer cells will mimic the metabolically stressful environment that tumor cells experience when growing within the lung tissue. In other words, we intend to develop novel 3-D culture systems of lung cancer cells as test-tube models of actual tumors. We will then utilize these tumor-like masses to explore the responses of energy-stressed cancer cells to known chemo- and radio-therapeutic agents, and, importantly, to identify novel targets and therapeutics for lung cancer treatment.

 Currently, nearly all of the laboratory research performed with human lung cancer cells employs decades-old technologies involving cells cultured as single-cell layers on plastic dishes. We hope to be able to change this paradigm by demonstrating the relevance and utility of 3-D culture systems for detailed dissections of tumor biology, and to prove that these systems offer unparalleled opportunities for the development of novel agents for cancer therapy. Importantly, our research squarely focuses on the tumor cells that oncologists consider most resistant to conventional chemotherapy and radiotherapy – the metabolically stressed cell that resides in the interior of the lung tumor mass. If our studies prove to be successful, our findings may open completely new vistas in lung cancer research, and provide a considerable benefit in the therapy of lung cancer.
title: REA hiragana
Creators: name: Yamamoto, Akiko
Publisher: name: Benemérita Universidad Autónoma de Puebla
publisherIdentifier: https://ror.org/03p2z7827
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: FGUS-840 Lengua Extranjera Japonés I;Japanese 1
subject: Hiragana
subject: Nivel Básico
subject: Idioma Japonés
subject: Enseñanza
subject: Letras

description: Este es un REA diseñado con el propósito de auxiliar en los cursos de Idioma Japonés 1 en el aprendizaje y repaso del silabario hiragana