cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk factors for acute kidney injury in COVID-19 patients: an updated systematic review and meta-analysis
Creators: name: Zhang, Jialing
name: Pang, Qi
name: Zhou, Ting
name: Meng, Jiali
name: Dong, Xingtong
name: Wang, Zhe
name: Zhang, Aihua
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Mental Health

description: Acute kidney injury (AKI) is associated with increased mortality among coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk factors for the development of AKI in patients with COVID-19. A systematic literature search was conducted in PubMed and EMBASE from 1 December 2019 to 1 January 2023. Due to significant study heterogeneity, meta-analyses were conducted using random-effects models. Meta-regression and sensitivity analysis were also performed. A total of 153,600 COVID-19 patients from 39 studies were included, and 28,003 patients developed AKI. By meta-analysis, we discovered that age, male sex, obesity, black race, invasive ventilation, and the use of diuretics, steroids and vasopressors, in addition to comorbidities such as hypertension, congestive heart failure, chronic kidney disease, acute respiratory distress syndrome, and diabetes, were significant risk factors for COVID-19-associated AKI. Early detection of these risk factors is essential to reduce the incidence of AKI and improve the prognosis of COVID-19 patients.
Rezension zu: Cicero’s De Provinciis Consularibus Oratio. Introduction and commentary by Luca Grillo
Creators: name: Steinmann, Marc
Publisher: name: Frankfurter elektronische Rundschau zur Altertumskunde
Year: 2016

description: Frankfurter elektronische Rundschau zur Altertumskunde, Nr. 29 (2016)
sj-pdf-1-jcb-10.1177_0271678X20926787 - Supplemental material for MicroRNA-30a regulates acute cerebral ischemia-induced blood–brain barrier damage through ZnT4/zinc pathway
Creators: name: Wang, Peng
name: Pan, Rong
name: Weaver, John
name: Jia, Mengjie
name: Yang, Xue
name: Yang, Tianhui
name: Liang, Jia
name: Liu, Ke J
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Emergency Medicine
subject: Endocrinology
subject: Medicine
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: Biological Sciences not elsewhere classified
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X20926787 for MicroRNA-30a regulates acute cerebral ischemia-induced blood–brain barrier damage through ZnT4/zinc pathway by Peng Wang, Rong Pan, John Weaver, Mengjie Jia, Xue Yang, Tianhui Yang, Jia Liang and Ke J Liu in Journal of Cerebral Blood Flow & Metabolism
dci20_0023_Supplementary_rev2 – Supplemental material for Diabetes Self-management Education and Support in Adults With Type 2 Diabetes: A Consensus Report of the American Diabetes Association, the Association of Diabetes Care & Education Specialists, the Academy of Nutrition and Dietetics, the American Academy of Family Physicians, the American Academy of PAs, the American Association of Nurse Practitioners, and the American Pharmacists Association
Creators: name: Powers, Margaret A.
name: Bardsley, Joan K.
name: Cypress, Marjorie
name: Funnell, Martha M.
name: Harms, Dixie
name: Hess-Fischl, Amy
name: Beulette Hooks
name: Isaacs, Diana
name: Mandel, Ellen D.
name: Maryniuk, Melinda D.
name: Norton, Anna
name: Rinker, Joanne
name: Siminerio, Linda M.
name: Uelmen, Sacha
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, dci20_0023_Supplementary_rev2 for Diabetes Self-management Education and Support in Adults With Type 2 Diabetes: A Consensus Report of the American Diabetes Association, the Association of Diabetes Care & Education Specialists, the Academy of Nutrition and Dietetics, the American Academy of Family Physicians, the American Academy of PAs, the American Association of Nurse Practitioners, and the American Pharmacists Association by Margaret A. Powers, Joan K. Bardsley, Marjorie Cypress, Martha M. Funnell, Dixie Harms, Amy Hess-Fischl, Beulette Hooks, Diana Isaacs, Ellen D. Mandel, Melinda D. Maryniuk, Anna Norton, Joanne Rinker, Linda M. Siminerio and Sacha Uelmen in The Diabetes Educator
Combination of the gut microbiota and clinical indicators as a potential index for differentiating idiopathic membranous nephropathy and minimal change disease
Creators: name: Jiang, Yumin
name: Wang, Ting
name: Yu, Wei
name: Wu, Feng
name: Guo, Ruixue
name: Li, Huangmin
name: Zhang, Yiding
name: Yan, Ge
name: Wang, Li
name: Zhao, Zhanzheng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Marine Biology

description: Membranous nephropathy (MN) and minimal change disease (MCD) are two common types of nephrotic syndrome that have similar clinical presentations but require different treatment strategies. Currently, the definitive diagnosis for these conditions relies on invasive renal biopsy, which can be limited in clinical practice. In this study, we aimed to differentiate idiopathic MN (IMN) from MCD using clinical data and gut microbiota. We collected clinical data and stool samples from 115 healthy individuals, 115 IMN, and 45 MCD at the onset of disease and performed 16S rRNA sequencing. Through machine learning methods including random forest, logistic regression, and support vector machine, a classifier to differentiate IMN from MCD was constructed. Baseline clinical data comparing the IMN and MCD groups showed that the MCD had higher levels of hemoglobin, uric acid, cystatin C, β2-microglobulin, α1-microglobulin, total cholesterol, and low-density lipoprotein and lower levels of albumin and CD4+ T-cell counts. The gut microbiota of the two groups differed at all levels of the phylum and genus. Differential gut microbiota may disturb the integrity of the intestinal wall and lead to the passage of inflammatory mediators through the intestinal barrier, causing kidney injury. We constructed a noninvasive classifier with a discrimination efficacy of 0.939 that combined the clinical data and gut microbiota information to identify IMN and MCD. The classifier of the gut microbiota combined with clinical indicators has achieved good performance in identifying IMN and MCD, which provides a new approach for the noninvasive discrimination of different pathological types of kidney disease.
Supplemental_material_v3 – Supplemental material for Time Course of Wrist Hyper-Resistance in Relation to Upper Limb Motor Recovery Early Post stroke
Creators: name: Andringa, Aukje
name: Meskers, Carel
name: Port, Ingrid Van De
name: Wegen, Erwin Van
name: Kwakkel, Gert
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, Supplemental_material_v3 for Time Course of Wrist Hyper-Resistance in Relation to Upper Limb Motor Recovery Early Post stroke by Aukje Andringa, Carel Meskers, Ingrid van de Port, Erwin van Wegen and Gert Kwakkel in Neurorehabilitation and Neural Repair
Rezension zu: Werner Eck/Peter Funke (Hg.), Öffentlichkeit – Monument – Text: XIV Congressus Internationalis Epigraphiae Graecae et Latinae, 27.-31. Augusti MMXII – Akten
Creators: name: Wiegels, Rainer
Publisher: name: Frankfurter elektronische Rundschau zur Altertumskunde
Year: 2016

description: Frankfurter elektronische Rundschau zur Altertumskunde, Nr. 29 (2016)
Supplementary_Table_1 – Supplemental material for Quality of Life Questionnaire-Bronchiectasis: a study of the psychometric properties of the Brazilian Portuguese version
Creators: name: Cristiane O De Camargo
name: José, Anderson
name: Luppo, Adriano
name: Camargo, Anderson A De
name: Athanazio, Rodrigo A
name: Rached, Samia Z
name: Quittner, Alexandra L
name: Stelmach, Rafael
name: Corso, Simone Dal
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, Supplementary_Table_1 for Quality of Life Questionnaire-Bronchiectasis: a study of the psychometric properties of the Brazilian Portuguese version by Cristiane O de Camargo, Anderson José, Adriano Luppo, Anderson A de Camargo, Rodrigo A Athanazio, Samia Z Rached, Alexandra L Quittner, Rafael Stelmach and Simone Dal Corso in Clinical Rehabilitation
Annotationes Epigraphicae V. Zu einigen Inschriften aus den Provinzen Germania inferior und Germania superior
Creators: name: Kakoschke, Andreas
Publisher: name: Frankfurter elektronische Rundschau zur Altertumskunde
Year: 2016

description: -
description: Frankfurter elektronische Rundschau zur Altertumskunde, Nr. 30 (2016)
Rezension zu: Monika Rekowska, In Pursuit of Ancient Cyrenaica…Two Hundred Years of Exploration Set Against the History of Archaeology in Europe (1706-1911)
Creators: name: Crisà, Antonino
Publisher: name: Frankfurter elektronische Rundschau zur Altertumskunde
Year: 2016

description: -
description: Frankfurter elektronische Rundschau zur Altertumskunde, Nr. 30 (2016)
Supplemental_material_-_SIRS – Supplemental material for The impact of participatory arts in promoting social relationships for older people within care homes
Creators: name: A Dadswell
name: H Bungay
name: C Wilson
name: C Munn-Giddings
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, Supplemental_material_-_SIRS for The impact of participatory arts in promoting social relationships for older people within care homes by A Dadswell, H Bungay, C Wilson and C Munn-Giddings in Perspectives in Public Health
Tournament_Mobility_Visualization_Supplementary_Information_20200402_clean – Supplemental material for Tournament Mobility in Mathematics Course-Taking Pathways
Creators: name: Hanselman, Paul
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, Tournament_Mobility_Visualization_Supplementary_Information_20200402_clean for Tournament Mobility in Mathematics Course-Taking Pathways by Paul Hanselman in Socius
Prediction of hyperkalemia in ESRD patients by identification of multiple leads and multiple features on ECG
Creators: name: Xu, Daojun
name: Zhou, Bin
name: Zhang, Jiaqi
name: Li, Chenyu
name: Guan, Chen
name: Liu, Yuxuan
name: Li, Lin
name: Li, Haina
name: Cui, Li
name: Xu, Lingyu
name: Liu, Hang
name: Zhen, Li
name: Xu, Yan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Cell Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Patients with end-stage renal disease (ESRD) especially those undergoing dialysis have a high prevalence of hyperkalemia, which must be detected and treated immediately. But the initial symptoms of hyperkalemia are insidious, and traditional laboratory serum potassium concentration testing takes time. Therefore, rapid and real-time measurement of serum potassium is urgently needed. In this study, different machine learning methods were used to make rapid predictions of different degrees of hyperkalemia by analyzing the ECG. A total of 1024 datasets of ECG and serum potassium concentrations were analyzed from December 2020 to December 2021. The data were scaled into training and test sets. Different machine learning models (LR, SVM, CNN, XGB, Adaboost) were built for dichotomous prediction of hyperkalemia by analyzing 48 features of chest leads V2-V5. The performance of the models was also evaluated and compared using sensitivity, specificity, accuracy, accuracy, F1 score and AUC. We constructed different machine models to predict hyperkalemia using LR and four other common machine-learning methods. The AUCs of the different models ranged from 0.740 (0.661, 0.810) to 0.931 (0.912,0.953) when different serum potassium concentrations were used as the diagnostic threshold for hyperkalemia, respectively. As the diagnostic threshold of hyperkalemia was raised, the sensitivity, specificity, accuracy and precision of the model decreased to various degrees. And AUC also performed less well than when predicting mild hyperkalemia. Noninvasive and rapid prediction of hyperkalemia can be achieved by analyzing specific waveforms on the ECG by machine learning methods. But overall, XGB had a higher AUC in mild hyperkalemia, but SVM performed better in predicting more severe hyperkalemia.
Convex bodies with equipotential circles
Creators: name: González-García, Iván
name: Jerónimo-Castro, Jesús
name: Jiménez-Desantiago, Valentín
name: Morales-Amaya, Efrén
Publisher: name: arXiv
Year: 2021
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: Given a convex body $K\subset \mathbb R^2$ we say that a circle $Ω\subset \text{int} \ K$ is an equipotential circle if every tangent line of $Ω$ cuts a chord $AB$ in $K$ such that for the contact point $P=Ω\cap AB$ it holds that $|AP|\cdot|PB|=λ$, for a suitable constant number $λ$. The main result in this article is the following: Let $K\subset\mathbb R^2$ be a convex body which has an equipotential circle $\mathcal B$ with centre $O$ in its interior. Then $K$ has centre of symmetry at $O$, moreover, if none chord of $K$ which is tangent to $\mathcal B$ subtends an angle $π/2$ from $O$, then $K$ is a disc. We also derive some results which characterizes the ellipsoid and the sphere in $\mathbb R^3$ and introduce also the concept of equireciprocal disc.
Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice
Creators: name: Ji, Pengmin
name: Shi, Qifeng
name: Liu, Yan
name: Han, Min
name: Su, Yong
name: Sun, Ran
name: Zhou, Huimin
name: Li, Weizu
name: Li, Weiping
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but the mechanism is unclear. NADPH oxidase 4 (NOX4) is an essential reactive oxygen species (ROS) source in the kidney. The mitogen-activated protein kinase (MAPK) signaling may exacerbate renal fibrosis. Therefore, we hypothesized that Rg1 might alleviate renal injury and fibrosis by inhibiting NOX4 and MAPK signaling in T2DM-induced DKD. We found that Rg1 significantly improves lipid deposition, fibrosis, and ROS production and reduces NOX4, p22phox, p47phox, p-ERK, p-JNK, and p-P38 MAPK expressions in the T2DM mice kidneys. We also found that the high-fat diet treatment in mice and the palmitate (PA) and PA + HG (high glucose) exposure in human mesangial cells could significantly induce lipid deposition, ROS production, fibrosis, and the activation of NOX4–MAPK signaling. The results suggest that high lipid and glucose may play a significant role in DKD progression, while Rg1 may attenuate renal fibrosis by inhibiting NOX4–MAPK signaling.
Risk of chronic kidney disease in children who developed acute kidney injury secondary to nephrotoxic medication exposure in infancy
Creators: name: Ameta, Priyanka
name: Stoops, Christine
name: Askenazi, David J.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Marine Biology

description: Nephrotoxic medication (NTM) is one of the common causes of acute kidney injury (AKI) in critically ill infants. Current knowledge about the long-term effects of NTM exposure and associated AKI during the neonatal period and early infancy is limited. Hence, we aimed to explore the risk of chronic kidney disease (CKD) after NTM-AKI in this age group. We performed a cross-sectional study including children 2–7 years of age, who had a history of high NTM exposure during NICU hospitalization. Cases and controls were defined as children who developed AKI and who did not develop AKI after NTM exposure, respectively. The primary outcome of interest was to explore the prevalence of composite CKD. In addition, we explored differences in urinary biomarker kidney injury molecule-1 (KIM-1) between the groups. We enrolled 48 children, 18 cases and 30 controls in which 25/48 (52%) had at least one finding of CKD. The composite CKD outcome tended to be higher in cases vs controls (61.1% vs. 46.6%, odds ratio = 1.79 (95% confidence interval 0.54-5.8)); however, this was not statistically significant. Median urinary KIM-1 value trended higher in controls, 0.367(0.23-0.59) vs. 0.20 (IQR 0.11-0.47), which was not statistically significant. In this study, 52% of children exposed to NTM had at least one marker of CKD at a median age of 5 years. Multicenter, large prospective studies are needed to improve our understanding of the natural course of NTM-AKI and to determine risk factors and strategies to reduce CKD in this high-risk population.
A modified renal angina index in critically ill patients with COVID-19
Creators: name: Del Toro-Cisneros, Noemi
name: Berman-Parks, Nathan
name: Uribe-Pérez, Adela
name: Caballero-Islas, Adrián E.
name: Vega-Vega, Olynka
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: The renal angina index (RAI) is a tool that has been validated by several studies in the pediatric population to predict the development of severe acute kidney injury (AKI). The aims of this study were to evaluate the efficacy of the RAI in predicting severe AKI in critically ill patients with COVID-19 and to propose a modified RAI (mRAI) for this population. This was a prospective cohort analysis of all COVID-19 patients receiving invasive mechanical ventilation (IMV) who were admitted to the intensive care unit (ICU) of a third-level hospital in Mexico City from 03/2020 to 01/2021. AKI was defined according to KDIGO guidelines. The RAI score was calculated for all enrolled patients using the method of Matsuura. Since all patients had the highest score for the condition (due to receiving IMV), the score corresponded to the delta creatinine (ΔSCr) value. The main outcome was severe AKI (stage 2 or 3) at 24 and 72 h after ICU admission. A logistic regression analysis was applied to search for factors associated with the development of severe AKI, and the data were applied to develop a mRAI and compare it vis-à-vis the efficacy of both scores (RAI and mRAI). Of the 452 patients studied, 30% developed severe AKI. The original RAI score was associated with AUCs of 0.67 and 0.73 at 24 h and 72 h, respectively, with a cutoff of 10 points to predict severe AKI. In the multivariate analysis adjusted for age and sex, a BMI ≥30 kg/m2, a SOFA score ≥6, and Charlson score were identified as risk factors for the development of severe AKI. In the new proposed score (mRAI), the conditions were summed and multiplied by the ΔSCr value. With these modifications, the AUC improved to 0.72 and 0.75 at 24 h and 72 h, respectively, with a cutoff of 8 points. The original RAI is a limited tool for patients with critical COVID-19 receiving IMV. The mRAI, with the parameters proposed in the present study, improves predictive performance and risk stratification in critically ill patients receiving IMV.
Association of dietary total antioxidant capacity with all-cause and cardiovascular mortality in patients with chronic kidney disease: based on two retrospective cohort studies of NHANES
Creators: name: Li, Yue
name: Ling, Gui-Chen
name: Ni, Rui-Bin
name: Ni, Shi-Hao
name: Sun, Shu-Ning
name: Liu, Xin
name: Deng, Jian-Ping
name: Ou-Yang, Xiao-Lu
name: Li, Jin
name: Xian, Shao-Xiang
name: Wang, Ling-Jun
name: Ye, Tao-Chun
name: Lu, Lu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Cancer
Science Policy

description: The relationship between dietary total antioxidant capacity (DTAC) and death risk among CKD populations remains unclear. Based on vitamin C equivalent antioxidant capacity (VCEAC) and the component dietary antioxidant index (CDAI) indices, we analyzed two cohorts to investigate the association of DTAC with all-cause and CVD mortality in CKD patients using data from National Health and Nutrition Examination Survey (2007–2018). VCEAC (n = 6330) and CDAI (n = 6300) cohorts with mortality follow-up data available through 2018 were included. Cox models with restricted cubic splines was used to model the nonlinear association between VCEAC/CDAI and outcomes in CKD patients. Our results showed L-shaped associations of DTAC with all-cause mortality among individuals with CKD stages 1–2 in both cohorts. Compared to the lowest quartile, higher dietary total antioxidant intake was associated with lower all-cause mortality risks among CKD stages 1–2 after adjustment for covariates, with HRs (95%CI) of 1.00, 0.91 (0.71,1.17), 0.69 (0.53,0.90), and 0.70 (0.54,0.91) in VCEAC, and similar respective estimate trends in CDAI. After sensitivity and subgroup analyses, there were no benefits for patients with stage 3–5 CKD or albuminuria. Mediation analysis revealed that the proportions mediated in both cohorts were less consistent. Moderate dietary total antioxidants intake has potential benefits for early-stage CKD patients. However, further evidence is needed to confirm whether patients with worsening CKD can benefit in the long term.
Supplemental Material, CONSORT_2010_Checklist - Prospective Randomized Controlled Trial to Study the Effect of Local Steroids in the Retropharyngeal Space After Anterior Cervical Discectomy and Fusion
Creators: name: Dahapute, Aditya
name: Sonone, Sandeep
name: Shubhanshu Bhaladhare
name: Kuber Sakhare
name: Marathe, Nandan
name: Balasubramanian, Sai Gautham
name: Swapnil Keny
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental Material, CONSORT_2010_Checklist for Prospective Randomized Controlled Trial to Study the Effect of Local Steroids in the Retropharyngeal Space After Anterior Cervical Discectomy and Fusion by Aditya Dahapute, Sandeep Sonone, Shubhanshu Bhaladhare, Kuber Sakhare, Nandan Marathe, Sai Gautham Balasubramanian and Swapnil Keny in Global Spine Journal
Appendix_A_Table_3 – Supplemental material for The criteria used by key decision makers in Australia to judge the academic quality of NTROs
Creators: name: McKee, Alan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, Appendix_A_Table_3 for The criteria used by key decision makers in Australia to judge the academic quality of NTROs by Alan McKee in Media International Australia
Using elastography-based multilayer perceptron model to evaluate renal fibrosis in chronic kidney disease
Creators: name: Chen, Ziman
name: Ying, Tin Cheung
name: Chen, Jiaxin
name: Wu, Chaoqun
name: Li, Liujun
name: Chen, Hui
name: Xiao, Ting
name: Huang, Yongquan
name: Chen, Xuehua
name: Jiang, Jun
name: Wang, Yingli
name: Lu, Wuzhu
name: Su, Zhongzhen
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Pharmacology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Marine Biology
Science Policy

description: Given its progressive deterioration in the clinical course, noninvasive assessment and risk stratification for the severity of renal fibrosis in chronic kidney disease (CKD) are required. We aimed to develop and validate an end-to-end multilayer perceptron (MLP) model for assessing renal fibrosis in CKD patients based on real-time two-dimensional shear wave elastography (2D-SWE) and clinical variables. From April 2019 to December 2021, a total of 162 patients with CKD who underwent a kidney biopsy and 2D-SWE examination were included in this single-center, cross-sectional, and prospective clinical study. 2D-SWE was performed to measure the right renal cortex stiffness, and the corresponding elastic values were recorded. Patients were categorized into two groups according to their histopathological results: mild and moderate-severe renal fibrosis. The patients were randomly divided into a training cohort (n = 114) or a test cohort (n = 48). The MLP classifier using a machine learning algorithm was used to construct a diagnostic model incorporating elastic values with clinical features. Discrimination, calibration, and clinical utility were used to appraise the performance of the established MLP model in the training and test sets, respectively. The developed MLP model demonstrated good calibration and discrimination in both the training [area under the receiver operating characteristic curve (AUC) = 0.93; 95% confidence interval (CI) = 0.88 to 0.98] and test cohorts [AUC = 0.86; 95% CI = 0.75 to 0.97]. A decision curve analysis and a clinical impact curve also showed that the MLP model had a positive clinical impact and relatively few negative effects. The proposed MLP model exhibited the satisfactory performance in identifying the individualized risk of moderate-severe renal fibrosis in patients with CKD, which is potentially helpful for clinical management and treatment decision-making.
Appendix_B – Supplemental material for The criteria used by key decision makers in Australia to judge the academic quality of NTROs
Creators: name: McKee, Alan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, Appendix_B for The criteria used by key decision makers in Australia to judge the academic quality of NTROs by Alan McKee in Media International Australia
Machine learning algorithm to predict the in-hospital mortality in critically ill patients with chronic kidney disease
Creators: name: Li, Xunliang
name: Zhu, Yuyu
name: Zhao, Wenman
name: Shi, Rui
name: Wang, Zhijuan
name: Pan, Haifeng
name: Wang, Deguang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: This study aimed to establish and validate a machine learning (ML) model for predicting in-hospital mortality in critically ill patients with chronic kidney disease (CKD). This study collected data on CKD patients from 2008 to 2019 using the Medical Information Mart for Intensive Care IV. Six ML approaches were used to build the model. Accuracy and area under the curve (AUC) were used to choose the best model. In addition, the best model was interpreted using SHapley Additive exPlanations (SHAP) values. There were 8527 CKD patients eligible for participation; the median age was 75.1 (interquartile range: 65.0–83.5) years, and 61.7% (5259/8527) were male. We developed six ML models with clinical variables as input factors. Among the six models developed, the eXtreme Gradient Boosting (XGBoost) model had the highest AUC, at 0.860. According to the SHAP values, the sequential organ failure assessment score, urine output, respiratory rate, and simplified acute physiology score II were the four most influential variables in the XGBoost model. In conclusion, we successfully developed and validated ML models for predicting mortality in critically ill patients with CKD. Among all ML models, the XGBoost model is the most effective ML model that can help clinicians accurately manage and implement early interventions, which may reduce mortality in critically ill CKD patients with a high risk of death.
sj-pdf-1-imr-10.1177_0300060520903612 - Supplemental material for Astragalus polysaccharides protect renal function and affect the TGF-β/Smad signaling pathway in streptozotocin-induced diabetic rats
Creators: name: Meng, Xue
name: Wei, Mingmin
name: Wang, Dong
name: Qu, Xiaohan
name: Zhang, Kun
name: Zhang, Nan
name: Li, Xinjian
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_0300060520903612 for Astragalus polysaccharides protect renal function and affect the TGF-β/Smad signaling pathway in streptozotocin-induced diabetic rats by Xue Meng, Mingmin Wei, Dong Wang, Xiaohan Qu, Kun Zhang, Nan Zhang and Xinjian Li in Journal of International Medical Research
title: Old School, San Antonio
Creators: name: Russel, Heather
Publisher: name: Georgia State University
Year: 2008

description: This collection of stories is based on the author’s experiences as a middle school teacher at an alternative campus in south Texas, in a district whose population was largely comprised of Mexican-American and low-income families. The Eagle School is based on a program that existed in the 1990s to address the special needs of “bubble” students, children who were failing in elementary school because of factors such as poverty, neglect, and violence at home. Students were selected for the program based on recommendations from their counselors, with the hope that the small campus of twelve teachers would provide its 150 sixth, seventh, and eighth graders with a safe haven, allowing them to focusing on their studies. The ultimate goals of the program were to prevent students from dropping out of school and to engage them in interdisciplinary projects that would advance them academically, preparing them to return to their appropriate grade levels in high school.

Ms. Russel, a character based on the author, recounts stories of her efforts to help students at the Eagle School, as well as stories of her own friendships, aspirations, and disappointments off campus. Each story represents a distinct moment during the six years that she teaches at the Eagle School, and each focuses on a specific student or group of students whose conflicts complicate her own.
20-0049_supplementary_materials – Supplemental material for Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-Analysis
Creators: name: Giannopoulos, Stefanos
name: Ghanian, Sheila
name: Sahil A. Parikh
name: Secemsky, Eric A.
name: Schneider, Peter A.
name: Ehrin J. Armstrong
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Cardiology
subject: Medicine
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, 20-0049_supplementary_materials for Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Limb-Threatening Ischemia: A Systematic Review and Meta-Analysis by Stefanos Giannopoulos, Sheila Ghanian, Sahil A. Parikh, Eric Secemsky, Peter A. Schneider and Ehrin J. Armstrong in Journal of Endovascular Therapy
A Rockafellar-type theorem for non-traditional costs
Creators: name: Artstein-Avidan, Shiri
name: Sadovsky, Shay
name: Wyczesany, Katarzyna
Publisher: name: arXiv
Year: 2020
Subjects: subject: Metric Geometry (math.MG)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 49K27, 47A63

description: In this note, we present a unified approach to the problem of existence of a potential for the optimal transport problem with respect to non-traditional cost functions, that is, costs that assume infinite values. We establish a new method that relies on proving solvability of a special (possibly infinite) family of linear inequalities. When the index set of this family is countable, we give a necessary and sufficient condition on the coefficients that assures the existence of a solution, and which, in the setting of transport theory, we call $c$-path-boundedness. In the case of an uncountable index set, one needs an additional assumption for solvability. We propose a sufficient condition in this case. We note that any set admitting a potential must be $c$-path-bounded, and this condition replaces $c$-cyclic monotonicity from the classical theory, i.e. when the cost is real-valued. Our method also gives a new and elementary proof for the classical results of Rockafellar, Rochet and Rüschendorf.
description: This is a revised version that corrects a mistake in the published paper regarding the solvability of an uncountable family of inequalities
Supplement_I_-_QoL-B_1 – Supplemental material for Quality of Life Questionnaire-Bronchiectasis: a study of the psychometric properties of the Brazilian Portuguese version
Creators: name: Cristiane O De Camargo
name: José, Anderson
name: Luppo, Adriano
name: Camargo, Anderson A De
name: Athanazio, Rodrigo A
name: Rached, Samia Z
name: Quittner, Alexandra L
name: Stelmach, Rafael
name: Corso, Simone Dal
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, Supplement_I_-_QoL-B_1 for Quality of Life Questionnaire-Bronchiectasis: a study of the psychometric properties of the Brazilian Portuguese version by Cristiane O de Camargo, Anderson José, Adriano Luppo, Anderson A de Camargo, Rodrigo A Athanazio, Samia Z Rached, Alexandra L Quittner, Rafael Stelmach and Simone Dal Corso in Clinical Rehabilitation
Supplemental Material, sj-docx-3-tpx-10.1177_0192623320922849 - Immunohistochemical Characteristics of Thymomas and Hyperplastic Lesions in Wistar Hannover Rats
Creators: name: Tomonari, Yuki
name: Sato, Junko
name: Naoaki Yamada
name: Kurotaki, Tetsuro
name: Doi, Takuya
name: Kanno, Takeshi
name: Tsuchitani, Minoru
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental Material, sj-docx-3-tpx-10.1177_0192623320922849 for Immunohistochemical Characteristics of Thymomas and Hyperplastic Lesions in Wistar Hannover Rats by Yuki Tomonari, Junko Sato, Naoaki Yamada, Tetsuro Kurotaki, Takuya Doi, Takeshi Kanno and Minoru Tsuchitani in Toxicologic Pathology
Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients
Creators: name: Zhang, Ping
name: Xiang, Shilong
name: Liu, Bicheng
name: Wang, Xiaohui
name: Yang, Xiaoping
name: Ye, Chaoyang
name: Wang, Zunsong
name: Li, Yanlin
name: Zhou, Li
name: Wang, Caili
name: Li, Hongbo
name: Huang, Jian
name: Peng, Ai
name: Wang, Xiaoping
name: Wang, Deguang
name: Xiao, Jie
name: Chen, Wenli
name: Cheng, Hong
name: Mao, Nan
name: Wang, Jianqin
name: Yang, Lin
name: Chen, Jianghua
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Chronic kidney disease-associated pruritus (CKD-aP) is very common and sometimes refractory to treatment in hemodialysis patients. In a trial conducted in Japan, nalfurafine, effectively reduced itching of treatment-resistant CKD-aP. Our present bridging study aimed to evaluate the efficacy and safety of nalfurafine in Chinese cohort with refractory CKD-aP. In this phase III, multicenter bridging study conducted at 22 sites in China, 141 Chinese cases with refractory CKD-aP were randomly (2:2:1) assigned to receive 5 μg, 2.5 μg of nalfurafine or a placebo orally for 14 days in a double-blind manner. The primary end point was the mean decrease in the mean visual analogue scale (VAS) from baseline. A total of 141 patients were included. The primary endpoint analysis based on full analysis set (FAS), the difference of mean VAS decrease between 5 μg nalfurafine and placebo group was 11.37 mm (p = .041); the difference of mean VAS decrease between 2.5 μg and placebo group was 8.81 mm (p = .110). Both differences were greater than 4.13 mm, which met its predefined success criterion of at least 50% efficacy of the key Japanese clinical trial. The per protocol set (PPS) analysis got similar results. The incidence of adverse drug reactions (ADRs) was 49.1% in 5μg, 38.6% in 2.5 μg and 33.3% in placebo group. The most common ADR was insomnia, seen in 21 of the 114 nalfurafine patients. Oral nalfurafine effectively reduced itching with few significant ADRs in Chinese hemodialysis patients with refractory pruritus.
Risk factors and prognosis for coronavirus disease 2019 among 131 hemodialysis patients during the Omicron variant epidemic
Creators: name: Wen, Wen
name: Cai, Shiming
name: Li, Yuehong
name: Wu, Xianglan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: The present study evaluated the presentations and outcomes of coronavirus disease 2019 (COVID-19) among patients undergoing maintenance hemodialysis (MHD) and the impact of the Omicron BF.7 variant. Adult patients (age ≥ 18 years), who underwent MHD (dialysis vintage ≥ 3 months) at the Hemodialysis Center at Beijing Tsinghua Changgung Hospital between December 2022 and January 2023, were included based on predefined eligibility criteria. Clinical and laboratory characteristics were retrospectively collected. Among 131 patients who underwent MHD (10.7% vaccination rate), 106 (80.9%) tested positive for COVID-19. The prevalence of asymptomatic, mild, moderate, and severe COVID-19 was 8.5%, 58.5%, 17%, and 16%, respectively. Among the 97 patients with symptoms, 23 (23.7%) were hospitalized and six (5.7%) died. Fever was experienced by 74.2% of patients and respiratory symptoms were the most common (81.4%). Residual symptoms persisted in 20.9% of patients one month after the onset of COVID-19. COVID-19-positive hemodialysis patients were more likely to experience weight loss and exhibit reduced albumin levels compared to those without COVID-19 (p < .05). Compared with the asymptomatic group, patients with symptoms were younger, and exhibited higher interleukin-6 levels and lower post-infection phosphate levels (p < .05). Age, dialysis vintage, comorbidities, and inflammatory factors were positively associated with disease severity, while baseline albumin and hemoglobulin levels were associated with death (p < .05). In conclusion, COVID-19 was prevalent among patients undergoing MHD, even during the Omicron variant epidemic. Age, nutritional status, comorbidities, and inflammatory factors were associated with disease severity and prognosis.
Effects of sacubitril-valsartan in patients undergoing maintenance dialysis
Creators: name: Ding, Ying
name: Wan, Li
name: Zhang, Zhou-cang
name: Yang, Qing-hua
name: Ding, Jia-xiang
name: Qu, Zhen
name: Yu, Feng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Data on angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril-valsartan (SV) in patients undergoing maintenance dialysis is scarce. Our study aimed to investigate the effect of SV on patients undergoing dialysis. We retrospectively reviewed the data of end-stage kidney disease (ESRD) patients undergoing either peritoneal dialysis (PD) or hemodialysis (HD) in our center. A total of 51 patients receiving SV treatment were enrolled in the SV group. Another 51 age and sex-matched patients on dialysis without SV treatment were selected as the control group. All the patients were regularly followed up in the dialysis clinic. Their clinical, biochemical, and echocardiographic parameters were all recorded at baseline and during follow-up. The effect and safety of SV were further analyzed. A total of 102 ESRD patients on dialysis (51 patients in the SV group and 51 patients in the control group) were finally enrolled. The median follow-up time was 349 days (interquartile range [IQR]: 217–535 days). The level of B-type natriuretic peptide (BNP) (median [IQR] before and after SV treatment: 596.35 pg/ml [190.6–1714.85] vs. 188.7 pg/ml [83.34–600.35], p < 0.001) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) (median [IQR]: 6316.00 pg/ml [4552.00–28598.00] vs. 5074.00 pg/ml [2229.00–9851.00], p = 0.022) were significantly decreased after treatment with SV. The variant rate of left ventricular ejection fraction (LVEF) was significantly higher in the SV group compared to the control group, especially in the PD subgroup. No significant difference was found in other echocardiographic parameters between SV and control group. Subgroup analysis of the PD group showed an increase in daily PD ultrafiltration (median [IQR]: 400 ml/d [200-500] vs. 500 ml/d [200–850], p = 0.114) after SV treatment. Variant rate of overhydration (OH) measured by the body composition monitor (BCM) of the SV group were significantly different from the control group (median [IQR]: −13.13% [−42.85%–27.84%] vs. 0% [−17.95%–53.85%], p = 0.049). The rate of hyperkalemia was slightly higher but without significant difference before and after the introduction of SV (19.6% vs. 27.5%, p = 0.350). No event of hypotension and angioedema were observed. SV might have a cardio-protective role in ESRD patients undergoing dialysis, especially in PD patients. Serum potassium should be monitored during the treatment.
Cooperative Programming, Provisioning And Control For Time Critical Applications In Cloud
Creators: name: Zhao, Zhiming
Publisher: name: Zenodo
Year: 2016
Subjects: Time critical applications
cloud
quality of user experience
infrastructure programming
self-adapting systems

description: Critical time constraints in applications, such as network latency and jitter in live event broadcasting or processing delay for real-time sensor data in disaster early warning systems, require high performance supporting infrastructure, along with sophisticated optimization mechanisms for developing and integrating system components. Cloud environments provide virtualized, elastic, and controllable on-demand services for supporting complex application systems. The lack of software development tools and in particular cloud-oriented programming and control models make the development and operation of time critical cloud applications difficult and costly. A software workbench, which can couple the development, deployment and operation phases of time critical applications in cloud environments, will reduce the development complexity of building such applications and improve the efficiency of runtime application control.

The workbench has to provide not only a user-friendly graphical interface, and an advanced programming and control model for time critical cloud applications, but also automated provisioning and adaptation mechanisms that can be applied on heterogeneous cloud infrastructures. The workbench needs to fully explore the programmability and elasticity provided by cloud environments, and to provide an intuitive platform for allowing application developers, quality of service (QoS) engineers and application users to work cooperatively during the lifecycle of application development and deployment. In recent years, many cloud development tools and workbenches have been prototyped, e.g. for infrastructure customization and provisioning, for QoS-oriented cloud resource selection for cloud infrastructure provisioning, and for monitoring and runtime control These existing workbenches only focus however on part of the development phase or specification of applications; none of them are designed to meet the exact requirements for time critical applications specifically, especially not with support for programmable infrastructures.

In the EU H2020 project SWITCH (the Software Workbench for Interactive, Time Critical and Highly self-adaptive cloud applications), three highly customizable components are proposed for the application development, virtual infrastructure customization and provisioning, and runtime adaptability respectively. In this talk, we first discuss the key technical challenges in developing the workbench based on requirements analysis and technical review, and then present the current achievements in the development of the three subsystems.