cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The optimal range of serum intact parathyroid hormone for a lower risk of mortality in the incident hemodialysis patients
Creators: name: Zhou, Xiaoling
name: Guo, Yidan
name: Luo, Yang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: The serum intact parathyroid hormone (iPTH) is associated with the prognosis of hemodialysis (HD) patients, however, its optimal range for reducing mortality remains inconsistent. We designed a prospective cohort study of 346 incident HD patients to assess the association between different serum iPTH level and mortality. According to the Kidney Disease Outcomes Quality Initiative (K/DOQI) international guidelines (2003), we divided patients into three groups (iPTH < 150 pg/mL, 150–300 pg/mL and >300 pg/mL). During the median follow-up of 58 months, 157 patients (45.38%) died. Multivariate Cox regression analysis showed that iPTH < 150 pg/mL and >300 pg/mL were associated with all-cause and cardiovascular mortality. Then, we performed a sensitivity analysis of patients divided into 6 serum PTH levels groups according to the folds of the K/DOQI target range. Multivariate Cox regression analysis showed that patients with serum iPTH ≥750 pg/mL, 600–749 pg/mL, 450–599 pg/mL had significantly higher risk of all-cause and cardiovascular mortality compared with those with serum iPTH in the range of 150–299 pg/mL. The association between serum iPTH and mortality shows a U-shaped curve. The optimal serum iPTH level which confers the lowest risk of all-cause and cardiovascular mortality could range from 150 pg/mL to 450 pg/mL in this group of incident HD patients.
Listronotus pseudosetosus O'Brien 1981
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus pseudosetosus

description: Listronotus pseudosetosus O’Brien, 1981
 Listronotus pseudosetosus O’Brien, 1981: 110 (type locality: USA: Florida, Sarasota County, Myakka River State Park; type material: H: CWOB and P: 13 CWOB, FSCA, and USNM).
 Distribution. USA: Florida and Mississippi (O’Brien, 1981).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 45, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
The mid-infrared and CO gas properties of an extreme star-forming FeLoBAL quasar
Creators: name: Pitchford, Lura K.
name: Farrah, Duncan
name: Alatalo, Katherine
name: Afonso, José
name: Efstathiou, Andreas
name: Hatziminaoglou, Evanthia
name: Lacy, Mark
name: Urrutia, Tanya
name: Violino, Giulio
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a detailed study of a high-redshift iron low-ionization broad absorption line (FeLoBAL) quasar (SDSS1214 at $z = 1.046$), including new interferometric $^{12}$CO $J$=2-1 observations, optical through far-infrared photometry, and mid-infrared spectroscopy. The CO line is well-fit by a single Gaussian centered 40 kms$^{-1}$ away from the systemic velocity and implies a total molecular gas mass of $M_\textrm{gas} = 7.3 \times 10^{10} \textrm{M}_\odot$. The infrared SED requires three components: an active galactic nucleus (AGN) torus, an AGN polar dust component, and a starburst. The starburst dominates the infrared emission with a luminosity of log($L_\textrm{SB}[\textrm{L}_\odot]) = 12.91^{+0.02}_{-0.02}$, implying a star formation rate of about 2000 $\textrm{M}_{\odot}$yr$^{-1}$, the highest known among FeLoBAL quasars. The AGN torus and polar dust components are less luminous, at log($L_\textrm{AGN}[\textrm{L}_\odot]) = 12.36^{+0.14}_{-0.15}$ and log($L_\textrm{dust}[\textrm{L}_\odot]) = 11.75^{+0.26}_{-0.46}$, respectively. If all of the molecular gas is used to fuel the ongoing star formation, then the lower limit on the subsequent duration of the starburst is 40 Myr. We do not find conclusive evidence that the AGN is affecting the CO gas reservoir. The properties of SDSS1214 are consistent with it representing the endpoint of an obscured starburst transitioning through a LoBAL phase to that of a classical quasar.
description: 10 pages, 7 figures, 3 tables, accepted for publication in MNRAS
Worldsheet Derivation of a Large N Duality
Creators: name: Ooguri, Hirosi
name: Vafa, Cumrun
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We give a worldsheet proof of the equivalence between the U(N) Chern-Simons gauge theory on S^3 and the topological closed string theory on the resolved conifold geometry. When the `t Hooft coupling of the gauge theory is small, the dual closed string worldsheet develops a new branch. We show that the fluctuations of the worldsheet into this branch effectively correspond to ``holes'' on the worldsheet, generating an open string sector. This leads to a microscopic description of how the `t Hooft expansion of gauge theory amplitudes is reproduced in the closed string computation. We find that the closed string amplitudes also contain terms which are not captured in the `t Hooft expansion but are present in the exact computation in the gauge theory amplitudes. These arise when the whole Riemann surface is in the new branch. We also discuss the cases with SO and Sp gauge groups.
description: 39 pages, 9 figures
Identification and Validation of Carbonic Anhydrase II as the First Target of the Anti-Inflammatory Drug Actarit
Creators: name: Ghislat, Ghita
name: Rahman, Taufiq
name: Ballester, Pedro J.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: actarit
carbonic anhydrase II
malotilate
MolTarPred
target prediction

description: Background and purpose: Identifying the macromolecular targets of drug molecules is a fundamental aspect of drug discovery and pharmacology. Several drugs remain without known targets (orphan) despite large-scale in silico and in vitro target prediction efforts. Ligand-centric chemical-similarity-based methods for in silico target prediction have been found to be particularly powerful, but the question remains of whether they are able to discover targets for target-orphan drugs. Experimental Approach: We used one of these in silico methods to carry out a target prediction analysis for two orphan drugs: actarit and malotilate. The top target predicted for each drug was carbonic anhydrase II (CAII). Each drug was therefore quantitatively evaluated for CAII inhibition to validate these two prospective predictions. Key Results: Actarit showed in vitro concentration-dependent inhibition of CAII activity with submicromolar potency (IC50 = 422 nM) whilst no consistent inhibition was observed for malotilate. Among the other 25 targets predicted for actarit, RORγ (RAR-related orphan receptor-gamma) is promising in that it is strongly related to actarit’s indication, rheumatoid arthritis (RA). Conclusion and Implications: This study is a proof-of-concept of the utility of MolTarPred for the fast and cost-effective identification of targets of orphan drugs. Furthermore, the mechanism of action of actarit as an anti-RA agent can now be re-examined from a CAII-inhibitor perspective, given existing relationships between this target and RA. Moreover, the confirmed CAII-actarit association supports investigating the repositioning of actarit on other CAII-linked indications (e.g., hypertension, epilepsy, migraine, anemia and bone, eye and cardiac disorders).
Faint Submillimeter Counts from Deep 850 Micron Observations of the Lensing Clusters A370, A851, and A2390
Creators: name: Cowie, L. L.
name: Barger, A. J.
name: Kneib, J-P.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present deep 850 micron maps of three massive lensing clusters, A370, A851, and A2390, with well-constrained mass models. Our cluster exposure times are more than 2 to 5 times longer than any other published cluster field observations. We catalog the sources and determine the submillimeter number counts. The counts are best determined in the 0.3 to 2 mJy range where the areas are large enough to provide a significant sample. At 0.3 mJy the cumulative counts are 3.3 (1.3,6.3) 10^4 per square degree, where the upper and lower bounds in the brackets are the 90% confidence range. The surface density at these faint count limits enters the realm of significant overlap with other galaxy populations.The corresponding percentage of the extragalactic background light (EBL) residing in this flux range is about 45-65%, depending on the EBL measurement used. Given that 20-30% of the EBL is resolved at flux densities between 2 and 10 mJy, most of the submillimeter EBL is arising in sources above 0.3 mJy. We also performed a noise analysis to obtain an independent estimate of the counts. The upper bounds on the counts determined from the noise analysis closely match the upper limits obtained from the direct counts. The differential counts from this and other surveys can reasonably be described by the parameterization n(S)=3 10^4/(0.7 + S^3) per square degree per mJy with S in mJy, which also integrates to match the EBL.
Listronotus rotundicollis LeConte 1876
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus rotundicollis

description: Listronotus rotundicollis LeConte, 1876
 Listronotus rotundicollis LeConte, 1876: 132 (type locality: USA: Georgia; type material: H: MCZ).
 Listronotus cribricollis LeConte, 1876: 134 (type locality: USA: Georgia; type material: H: MCZ); Henderson, 1940: 271 (= L. rotundicollis).
 Listronotus setosus Pierce, 1907: 259 (misidentification, non LeConte, 1876); Henderson, 1940: 271 (= L. rotundicollis).
 Host plants. Crinum sp. (Amaryllidaceae) (O’Brien, 1977).
 Distribution. Costa Rica, Mexico: Yucatan Peninsula, and USA: from Pennsylvania to Florida, west to Oklahoma and Texas (O’Brien, 1977, 1981; O’Brien and Wibmer, 1982).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 45, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
An N=8 Superaffine Malcev Algebra and Its N=8 Sugawara
Creators: name: Carrion, H. L.
name: Rojas, M.
name: Toppan, F.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A supersymmetric affinization of the algebra of octonions is introduced. It satisfies a super-Malcev property and is N=8 supersymmetric. Its Sugawara construction recovers, in a special limit, the non-associative N=8 superalgebra of Englert et al. This paper extends to supersymmetry the results obtained by Osipov in the bosonic case.
description: 10 pages, LaTex
Understanding language-elicited EEG data by predicting it from a fine-tuned language model
Creators: name: Schwartz, Dan
name: Mitchell, Tom
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Electroencephalography (EEG) recordings of brain activity taken while participants read or listen to language are widely used within the cognitive neuroscience and psycholinguistics communities as a tool to study language comprehension. Several time-locked stereotyped EEG responses to word-presentations -- known collectively as event-related potentials (ERPs) -- are thought to be markers for semantic or syntactic processes that take place during comprehension. However, the characterization of each individual ERP in terms of what features of a stream of language trigger the response remains controversial. Improving this characterization would make ERPs a more useful tool for studying language comprehension. We take a step towards better understanding the ERPs by fine-tuning a language model to predict them. This new approach to analysis shows for the first time that all of the ERPs are predictable from embeddings of a stream of language. Prior work has only found two of the ERPs to be predictable. In addition to this analysis, we examine which ERPs benefit from sharing parameters during joint training. We find that two pairs of ERPs previously identified in the literature as being related to each other benefit from joint training, while several other pairs of ERPs that benefit from joint training are suggestive of potential relationships. Extensions of this analysis that further examine what kinds of information in the model embeddings relate to each ERP have the potential to elucidate the processes involved in human language comprehension.
description: To appear in Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics
A Comparison of the Chemical Composition of Main Sequence and Giant Stars in the Open Cluster NCC 752
Creators: name: Lum, Michael G.
name: Boesgaard, Ann Merchant
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The chemical composition of stars in open clusters provides the best information on the chemical evolution of stars via comparison of the main sequence stars with the evolved giants. This is a case study of the abundances in the dwarfs and giants in the old, open cluster, NGC 752. It is also a pilot program for automated abundance determinations, including equivalent width measurements, stellar parameter determinations, and abundance analysis. We have found abundances of 31 element-ion combinations in 23 dwarfs and 6 giants. The mean cluster abundance of Fe is solar with [Fe/H]$=-0.01\pm0.06$ with no significant difference between the dwarfs and giants. We find that the cluster abundances of other elements, including alpha-elements, to be at, or slightly above solar levels. We find some evidence for CNO processing in the spectra of the giants. The enhancement of Na in giants indicates that the NeNa cycle has occurred. The abundances of Mg and Al are similar in the dwarfs and giants indicating that the hotter MgAl cycle has not occurred. We find no evidence of s-process enhancements in the abundances of heavy elements in the giants.
description: 33 pages, 13 figures
Detecting the Sources of Information Rigidity: Analyzing Forecast Bias and Smoothing in USDA’s Soybean Forecasts
Creators: name: MacDonald, Stephen
name: Ash, Mark
name: MacDonald, Stephen
name: Ash, Mark
Publisher: name: Unknown
Year: 2016
Subjects: subject: Agribusiness
subject: Crop Production/Industries
subject: Demand and Price Analysis
subject: International Relations/Trade
subject: Research Methods/ Statistical Methods
subject: USDA
subject: forecasting
subject: forecast evaluation
subject: revision efficiency

description: USDA’s U.S. soybean ending stock forecasts are upwardly biased. To determine the source of this bias, we examine the revision characteristics of the ending stocks forecasts, and examine USDA’s forecasts of other U.S. soybean balance sheet variables and foreign soybean balance sheet variables. Bias in USDA’s soybean export forecasts is the most likely source of ending stock forecast bias. In turn, bias in the U.S. export forecasts has diverse sources, including bias in foreign trade estimates and late in the forecast cycle slow updating of the forecasts to reflect new information.
Detection of the self-regulation of star formation in galaxy discs
Creators: name: Zaragoza-Cardiel, Javier
name: Fritz, Jacopo
name: Aretxaga, Itziar
name: Mayya, Divakara
name: Rosa-González, Daniel
name: Beckman, John E.
name: Bruzual, Gustavo
name: Charlot, Stephane
name: Lomelí-Núñez, Luis
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Stellar feedback has a notable influence on the formation and evolution of galaxies. However, direct observational evidence is scarce. We have performed stellar population analysis using MUSE optical spectra of the spiral galaxy NGC 628 and find that current maximum star formation in spatially resolved regions is regulated according to the level of star formation in the recent past. We propose a model based on the self-regulator or "bathtub" models, but for spatially resolved regions of the galaxy. We name it the "resolved self-regulator model" and show that the predictions of this model are in agreement with the presented observations. We observe star formation self-regulation and estimate the mass-loading factor, $η=2.5 \pm 0.5$, consistent with values predicted by galaxy formation models. The method described here will help provide better constraints on those models.
description: Accepted for publication in MNRAS Letters. 6 pages, 3 figures
Confining Phase Superpotentials for SO/Sp Gauge Theories via Geometric Transition
Creators: name: Fuji, Hiroyuki
name: Ookouchi, Yutaka
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We examine a large N duality via geometric transition for N=1 SO/Sp gauge theories with superpotential for adjoint chiral superfield. In this paper, we find that the large N gauge theories are exactly analyzed for the classical quartic superpotentials by the finite rank SO/Sp gauge theories. With this classical superpotentials, we evaluate the confining phase superpotentials using the Seiberg-Witten theory. In the dual theory, we calculate the superpotential generated by the R-R and NS-NS 3-form fluxes. As the non-trivial examples, we discuss for SO(6), SO(8) and Sp(4) gauge theories. In these cases we have the perfect agreement of the confining phase superpotentials up to the 4th order of the glueball superfields.
description: 23 pages, 2 figures, Latex; v3, references added; v4, Explanation for orbifolding was slightly modified
New predictions for inclusive heavy-quarkonium P-wave decays
Creators: name: Brambilla, N.
name: Eiras, D.
name: Pineda, A.
name: Soto, J.
name: Vairo, A.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that some NRQCD colour-octet matrix elements can be written in terms of (derivatives of) wave functions at the origin and non-perturbative universal constants once the factorization between the soft and ultrasoft scale is achieved by using an effective field theory where only ultrasoft degrees of freedom are kept as dynamical entities. This allows us to derive a new set of relations between inclusive heavy-quarkonium P-wave decays into light hadrons with different principal quantum number and with different heavy flavour. In particular, we can estimate the branching ratios of bottomonium P-wave states by using charmonium data.
description: 4 pages, revtex
The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals
Creators: name: Wallis, Natalie
name: Raffan, Eleanor
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: obesity
genetics
companion animals
metabolic disease
comparative genomics
dogs
cats
horses

description: Obesity is one of the most prevalent health conditions in humans and companion animals globally. It is associated with premature mortality, metabolic dysfunction, and multiple health conditions across species. Obesity is, therefore, of importance in the fields of medicine and veterinary medicine. The regulation of adiposity is a homeostatic process vulnerable to disruption by a multitude of genetic and environmental factors. It is well established that the heritability of obesity is high in humans and laboratory animals, with ample evidence that the same is true in companion animals. In this review, we provide an overview of how genes link to obesity in humans, drawing on a wealth of information from laboratory animal models, and summarise the mechanisms by which obesity causes related disease. Throughout, we focus on how large-scale human studies and niche investigations of rare mutations in severely affected patients have improved our understanding of obesity biology and can inform our ability to interpret results of animal studies. For dogs, cats, and horses, we compare the similarities in obesity pathophysiology to humans and review the genetic studies that have been previously reported in those species. Finally, we discuss how veterinary genetics may learn from humans about studying precise, nuanced phenotypes and implementing large-scale studies, but also how veterinary studies may be able to look past clinical findings to mechanistic ones and demonstrate translational benefits to human research.
Stochastic growth in time dependent environments
Creators: name: Barraquand, Guillaume
name: Doussal, Pierre Le
name: Rosso, Alberto
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study the Kardar-Parisi-Zhang (KPZ) growth equation in one dimension with a noise variance $c(t)$ depending on time. We find that for $c(t)\propto t^{-α}$ there is a transition at $α=1/2$. When $α>1/2$, the solution saturates at large times towards a non-universal limiting distribution. When $α<1/2$ the fluctuation field is governed by scaling exponents depending on $α$ and the limiting statistics are similar to the case when $c(t)$ is constant. We investigate this problem using different methods: (1) Elementary changes of variables mapping the time dependent case to variants of the KPZ equation with constant variance of the noise but in a deformed potential (2) An exactly solvable discretization, the log-gamma polymer model (3) Numerical simulations.
description: v3: The exposition has been improved in the letter. Letter: 7 pages. Supplementary material: 33 pages
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma
Creators: name: Larrea, Erika
name: Fernandez-Mercado, Marta
name: Guerra-Assunção, José Afonso
name: Wang, Jun
name: Goicoechea, Ibai
name: Gaafar, Ayman
name: Ceberio, Izaskun
name: Lobo, Carmen
name: Okosun, Jessica
name: Enright, Anton J.
name: Fitzgibbon, Jude
name: Lawrie, Charles H.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: follicular lymphoma (FL)
diffuse large B-cell lymphoma (DLBCL)
microRNA
mutation

description: Follicular lymphoma (FL) is a common indolent B-cell lymphoma that can transform into the more aggressive transformed FL (tFL). However, the molecular process driving this transformation is uncertain. In this work, we aimed to identify microRNA (miRNA)-binding sites recurrently mutated in follicular lymphoma patients, as well as in transformed FL patients. Using whole-genome sequencing data from FL tumors, we discovered 544 mutations located in bioinformatically predicted microRNA-binding sites. We then studied these specific regions using targeted sequencing in a cohort of 55 FL patients, found 16 recurrent mutations, and identified a further 69 variants. After filtering for QC, we identified 21 genes with mutated miRNA-binding sites that were also enriched for B-cell-associated genes by Gene Ontology. Over 40% of mutations identified in these genes were present exclusively in tFL patients. We validated the predicted miRNA-binding sites of five of the genes by luciferase assay and demonstrated that the identified mutations in BCL2 and EZH2 genes impaired the binding efficiency of miR-5008 and miR-144 and regulated the endogenous levels of messenger RNA (mRNA).
Self-Aligned Top-Gate Metal-Oxide Thin-Film Transistors Using a Solution-Processed Polymer Gate Dielectric
Creators: name: Choi, Seungbeom
name: Song, Seungho
name: Kim, Taegyu
name: Shin, Jae Cheol
name: Jo, Jeong-Wan
name: Park, Sung Kyu
name: Kim, Yong-Hoon
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: self-aligned
top-gate
thin-film transistor
solution process
polymer gate dielectric

description: For high-speed and large-area active-matrix displays, metal-oxide thin-film transistors (TFTs) with high field-effect mobility, stability, and good uniformity are essential. Moreover, reducing the RC delay is also important to achieve high-speed operation, which is induced by the parasitic capacitance formed between the source/drain (S/D) and the gate electrodes. From this perspective, self-aligned top-gate oxide TFTs can provide advantages such as a low parasitic capacitance for high-speed displays due to minimized overlap between the S/D and the gate electrodes. Here, we demonstrate self-aligned top-gate oxide TFTs using a solution-processed indium-gallium-zinc-oxide (IGZO) channel and crosslinked poly(4-vinylphenol) (PVP) gate dielectric layers. By applying a selective Ar plasma treatment on the IGZO channel, low-resistance IGZO regions could be formed, having a sheet resistance value of ~20.6 kΩ/sq., which can act as the homojunction S/D contacts in the top-gate IGZO TFTs. The fabricated self-aligned top-gate IGZO TFTs exhibited a field-effect mobility of 3.93 cm2/Vs and on/off ratio of ~106, which are comparable to those fabricated using a bottom-gate structure. Furthermore, we also demonstrated self-aligned top-gate TFTs using electrospun indium-gallium-oxide (IGO) nanowires (NWs) as a channel layer. The IGO NW TFTs exhibited a field-effect mobility of 0.03 cm2/Vs and an on/off ratio of >105. The results demonstrate that the Ar plasma treatment for S/D contact formation and the solution-processed PVP gate dielectric can be implemented in realizing self-aligned top-gate oxide TFTs.
Additional file 1 of Three Gorges Dam: the changing trend of snail density in the Yangtze River basin between 1990 and 2019
Creators: name: Gong, Yanfeng
name: Tong, Yixin
name: Jiang, Honglin
name: Xu, Ning
name: Yin, Jiangfan
name: Wang, Jiamin
name: Huang, Junhui
name: Chen, Yue
name: Jiang, Qingwu
name: Li, Shizhu
name: Zhou, Yibiao
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1: Figure S1. Spatial distribution of the sample points between 1990–2019. Figure S2. Mean snail density between 2015 and 2019.
Correlating Radiomic Features of Heterogeneity on CT with Circulating Tumor DNA in Metastatic Melanoma
Creators: name: Gill, Andrew B
name: Rundo, Leonardo
name: Wan, Jonathan C. M.
name: Lau, Doreen
name: Zawaideh, Jeries P.
name: Woitek, Ramona
name: Zaccagna, Fulvio
name: Beer, Lucian
name: Gale, Davina
name: Sala, Evis
name: Couturier, Dominique-Laurent
name: Corrie, Pippa G.
name: Rosenfeld, Nitzan
name: Gallagher, Ferdia A.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: liquid biopsy
circulating tumor DNA
tumor heterogeneity
tumor imaging
radiomics

description: Clinical imaging methods, such as computed tomography (CT), are used for routine tumor response monitoring. Imaging can also reveal intratumoral, intermetastatic, and interpatient heterogeneity, which can be quantified using radiomics. Circulating tumor DNA (ctDNA) in the plasma is a sensitive and specific biomarker for response monitoring. Here we evaluated the interrelationship between circulating tumor DNA mutant allele fraction (ctDNAmaf), obtained by targeted amplicon sequencing and shallow whole genome sequencing, and radiomic measurements of CT heterogeneity in patients with stage IV melanoma. ctDNAmaf and radiomic observations were obtained from 15 patients with a total of 70 CT examinations acquired as part of a prospective trial. 26 of 39 radiomic features showed a significant relationship with log(ctDNAmaf). Principal component analysis was used to define a radiomics signature that predicted ctDNAmaf independent of lesion volume. This radiomics signature and serum lactate dehydrogenase were independent predictors of ctDNAmaf. Together, these results suggest that radiomic features and ctDNAmaf may serve as complementary clinical tools for treatment monitoring.
Listronotus rubtzoffi O'Brien 1981
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus rubtzoffi

description: Listronotus rubtzoffi O’Brien, 1981
 Listronotus rubtzoffi O’Brien, 1981: 113 (type locality: USA: California, Marin County, Laguna, Chileno Valley; type material: H: CWOB and P: 55 BMNH, CASC, CWOB, TAMU, and USNM).
 Host plants. Sagittaria cuneata Sheldon (Alismataceae) (O’Brien, 1981).
 Distribution. USA: northern California (O’Brien, 1981).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 45, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Holography in the Penrose limit of AdS space
Creators: name: Siopsis, George
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the Penrose limit of pure AdS space, which is flat Minkowski space. Even though there is no holographic principle, we construct a ``holographic screen'' on which information on the corresponding CFT is encoded. The screen is obtained as a gauge-fixing condition upon restricting the Hilbert space to the states that are annihilated by the generator of scale transformations. This constraint leads to Dirac brackets which turn the Poincare algebra into the algebra of the conformal group on the ``holographic screen.''
description: 12 pages; v2 contains expanded discussion, to appear in Phys. Lett. B
Application of Genetic Algorithm for More Efficient Multi-Layer Thickness Optimization in Solar Cells
Creators: name: Vincent, Premkumar
name: Sergio, Gwenaelle Cunha
name: Jang, Jaewon
name: Kang, In Man
name: Park, Jaehoon
name: Kim, Hyeok
name: Lee, Minho
name: Bae, Jin-Hyuk
Publisher: name: arXiv
Year: 2019
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Thin-film solar cells are predominately designed similar to a stacked structure. Optimizing the layer thicknesses in this stack structure is crucial to extract the best efficiency of the solar cell. The commonplace method used in optimization simulations, such as for optimizing the optical spacer layers' thicknesses, is the parameter sweep. Our simulation study shows that the implementation of a meta-heuristic method like the genetic algorithm results in a significantly faster and accurate search method when compared to the brute-force parameter sweep method in both single and multi-layer optimization. While other sweep methods can also outperform the brute-force method, they do not consistently exhibit $100\%$ accuracy in the optimized results like our genetic algorithm. We have used a well-studied P3HT-based structure to test our algorithm. Our best-case scenario was observed to use $60.84\%$ fewer simulations than the brute-force method.
description: Published (https://www.mdpi.com/1996-1073/13/7/1726), Code (https://github.com/gcunhase/GeneticAlgorithm-SolarCells)
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity
Creators: name: Mikalauskaite, Kamile
name: Ziaunys, Mantas
name: Sneideris, Tomas
name: Smirnovas, Vytautas
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: amyloid
protein aggregation
ionic strength
thioflavin-T

description: The formation of amyloid fibrils is linked to multiple neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Despite years of research and countless studies on the topic of such aggregate formation, as well as their resulting structure, the current knowledge is still fairly limited. One of the main aspects prohibiting effective aggregation tracking is the environment’s effect on amyloid-specific dyes, namely thioflavin-T (ThT). Currently, there are only a few studies hinting at ionic strength being one of the factors that modulate the dye’s binding affinity and fluorescence intensity. In this work we explore this effect under a range of ionic strength conditions, using insulin, lysozyme, mouse prion protein, and α-synuclein fibrils. We show that ionic strength is an extremely important factor affecting both the binding affinity, as well as the fluorescence intensity of ThT.
Listronotus scapularis Casey 1895
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus scapularis

description: Listronotus scapularis Casey, 1895
 Listronotus scapularis Casey, 1895: 828 (type locality: USA: Texas, El Paso; type material: H: USNM and P: 1 USNM).
 Host plants. Sagittaria longiloba Engelm. ex J. G. Sm. and Sagittaria sp. (Alismataceae) (O’Brien, 1977).
 Distribution. Northern Mexico: Tamaulipas, central Nicaragua, and USA: from the Texas coast through central Texas to the northern Panhandle (O’Brien, 1977, 1981; Maes and O’Brien, 1990).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 46, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Descent Relations in Type 0A/0B
Creators: name: Thompson, David M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The type 0 theories have twice as many stable D-branes as the type II theories. In light of this added complication, we find the descent relations for D-branes in the type 0A and 0B theories. In addition, we work out how the two types of D-branes differ in their couplings to NS-NS fields.
description: 20 pages, LaTeX
Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease: A Fragment-Guided in Silico Approach
Creators: name: Augustin, Teresa L.
name: Hajbabaie, Roxanna
name: Harper, Matthew T.
name: Rahman, Taufiq
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: coronavirus
COVID-19
SARS-CoV-2 Mpro
main protease
fragment-guided
drug discovery
pharmacophore
molecular docking
natural products
in silico

description: The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 1 million deaths, and there is no cure or vaccine to date. The recently solved crystal structure of the SARS-CoV-2 main protease has been a major focus for drug-discovery efforts. Here, we present a fragment-guided approach using ZINCPharmer, where 17 active fragments known to bind to the catalytic centre of the SARS-CoV-2 main protease (SARS-CoV-2 Mpro) were used as pharmacophore queries to search the ZINC databases of natural compounds and natural derivatives. This search yielded 134 hits that were then subjected to multiple rounds of in silico analyses, including blind and focused docking against the 3D structure of the main protease. We scrutinised the poses, scores, and protein−ligand interactions of 15 hits and selected 7. The scaffolds of the seven hits were structurally distinct from known inhibitor scaffolds, thus indicating scaffold novelty. Our work presents several novel scaffolds as potential candidates for experimental validation against SARS-CoV-2 Mpro.
A gobal fit to the anomalous magnetic moment, Higgs limit and b->s gamma in the constrained MSSM
Creators: name: de Boer, W.
name: Huber, M.
name: Sander, C.
name: Gladyshev, A. V.
name: Kazakov, D. I.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: New data on the anomalous magnetic moment of the muon together with the b->s gamma decay rate and Higgs limits are considered within the supergravity inspired constrained minimal supersymmetric model. We perform a global statistical chi2 analysis of these data and show that the allowed region of parameter space is bounded from below by the Higgs limit, which depends on the trilinear coupling and from above by the anomalous magnetic moment.
description: 3 pages, To appear in Proc. of SUSY01, Dubna (Russia)
Additional file 1 of Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review
Creators: name: Asken, Breton M.
name: Rabinovici, Gil D.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Listronotus rufomarginatus
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus rufomarginatus

description: Listronotus rufomarginatus (Hustache, 1939)
 Hyperodes rufomarginatus Hustache, 1939a: 48 (type locality: Argentina: Buenos Aires, Isla Martín García; type material: S: 1 MLP).
 Listronotus rufomarginatus; O’Brien, 1979: 267.
 Distribution. Argentina (Wibmer and O'Brien, 1986).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 45, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project
Creators: name: Crabtree, Daniel R.
name: Buosi, William
name: Fyfe, Claire L.
name: Horgan, Graham W.
name: Manios, Yannis
name: Androutsos, Odysseas
name: Giannopoulou, Angeliki
name: Finlayson, Graham
name: Beaulieu, Kristine
name: Meek, Claire L.
name: Holst, Jens J.
name: Van Norren, Klaske
name: Mercer, Julian G.
name: Johnstone, Alexandra M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: appetite
lifecourse
gut hormones
hunger
protein

description: Understanding the mechanisms of hunger, satiety and how nutrients affect appetite control is important for successful weight management across the lifecourse. The primary aim of this study was to describe acute appetite control across the lifecourse, comparing age groups (children, adolescents, adults, elderly), weight categories, genders and European sites (Scotland and Greece). Participants (n = 391) consumed four test drinks, varying in composition (15% (normal protein, NP) and 30% (high protein, HP) of energy from protein) and quantity (based on 100% basal metabolic rate (BMR) and 140% BMR), on four separate days in a double-blind randomized controlled study. Ad libitum energy intake (EI), subjective appetite and biomarkers of appetite and metabolism (adults and elderly only) were measured. The adults’ appetite was significantly greater than that of the elderly across all drink types (p 0.004) and in response to drink quantities (p 0.001). There were no significant differences in EI between age groups, weight categories, genders or sites. Concentrations of glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) were significantly greater in the elderly than the adults (p 0.001). Ghrelin and fasting leptin concentrations differed significantly between weight categories, genders and sites (p 0.05), while GLP-1 and PYY concentrations differed significantly between genders only (p 0.05). Compared to NP drinks, HP drinks significantly increased postprandial GLP-1 and PYY (p 0.001). Advanced age was concomitant with reduced appetite and elevated anorectic hormone release, which may contribute to the development of malnutrition. In addition, appetite hormone concentrations differed between weight categories, genders and geographical locations.
A Maximum Principle for Combinatorial Yamabe Flow
Creators: name: Glickenstein, David
Publisher: name: arXiv
Year: 2002
Subjects: subject: Metric Geometry (math.MG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 52C26

description: This article studies a discrete geometric structure on triangulated manifolds and an associated curvature flow (combinatorial Yamabe flow). The associated evolution of curvature appears to be like a heat equation on graphs, but it can be shown to not satisfy the maximum principle. The notion of a parabolic-like operator is introduced as an operator which satisfies the maximum principle, but may not be parabolic in the usual sense of operators on graphs. A maximum principle is derived for the curvature of combinatorial Yamabe flow under certain assumptions on the triangulation, and hence the heat operator is shown to be parabolic-like. The maximum principle then allows a characterization of the curvature as well was a proof of long term existence of the flow.
description: 20 pages, this is an almost entirely different paper. Some elements of the old version are in the paper arxiv:math.MG/0506182
The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions
Creators: name: Zawisza-Álvarez, Michał
name: Pérez-Calles, Claudia
name: Gattoni, Giacomo
name: Garcia-Fernàndez, Jordi
name: Benito-Gutiérrez, Èlia
name: Herrera-Úbeda, Carlos
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: RNA-editing
invertebrates
evolution

description: RNA editing is a relatively unexplored process in which transcribed RNA is modified at specific nucleotides before translation, adding another level of regulation of gene expression. Cephalopods use it extensively to increase the regulatory complexity of their nervous systems, and mammals use it too, but less prominently. Nevertheless, little is known about the specifics of RNA editing in most of the other clades and the relevance of RNA editing from an evolutionary perspective remains unknown. Here we analyze a key element of the editing machinery, the ADAR (adenosine deaminase acting on RNA) gene family, in an animal with a key phylogenetic position at the root of chordates: the cephalochordate amphioxus. We show, that as in cephalopods, ADAR genes in amphioxus are predominantly expressed in the nervous system; we identify a number of RNA editing events in amphioxus; and we provide a newly developed method to identify RNA editing events in highly polymorphic genomes using orthology as a guide. Overall, our work lays the foundations for future comparative analysis of RNA-editing events across the metazoan tree.
إدارة المشروعات الصغيرة وعلاقتها بالإقتصاد المحلي والعالمي
Creators: name: Soliman, Ibrahim
name: Mahmoud Awida, Osama
name: Soliman, Ibrahim
name: Mahmoud Awida, Osama
Publisher: name: Unknown
Year: 1999
Subjects: subject: Marketing
subject: FOS: Economics and business
subject: Public Economics

description: الدورة التأهيلية لمشروع تعميق فكر العمل الحر لدي خريجي الكليات والمعاهد العليا، قدم الباحث خلاله محاضرات في "إدارة المشروعات الصغيرة وعلاقتها بالاقتصاد المحلي والعالمي" ضمن البرنامج التدريبي للصندوق الاجتماعي للتنمية التابع لمجلس الوزراء (فرع تنمية المشروعات) بالتعاون مع كلية الزراعة جامعة الزقازيق، الذي نظمه صندوق التنمية الاجتماعي في الفترة فبراير- مايو 1999 بالزقازيق
Data driven regularization by projection
Creators: name: Aspri, Andrea
name: Korolev, Yury
name: Scherzer, Otmar
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Paper
data driven regularization
variational regularization
regularization by projection
inverse problems
Gram–Schmidt orthogonalization

description: Abstract: We study linear inverse problems under the premise that the forward operator is not at hand but given indirectly through some input-output training pairs. We demonstrate that regularization by projection and variational regularization can be formulated by using the training data only and without making use of the forward operator. We study convergence and stability of the regularized solutions in view of Seidman (1980 J. Optim. Theory Appl. 30 535), who showed that regularization by projection is not convergent in general, by giving some insight on the generality of Seidman’s nonconvergence example. Moreover, we show, analytically and numerically, that regularization by projection is indeed capable of learning linear operators, such as the Radon transform.
Listronotus setosipennis
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Listronotus
Listronotus setosipennis

description: Listronotus setosipennis (Hustache, 1926)
 Hyperodes setosipennis Hustache, 1926: 205 (type locality: Argentina: Chaco de Santiago del Estero, Río Salado; type material: S: 6 MNHN).
 Hyperodes setosus Hustache, 1926: 212 (non LeConte, 1876) (type locality: Argentina: Buenos Aires; type material: H: MNHN); Kuschel, 1955: 289 (= H. setosipennis).
 Hyperodes setossus Hustache, 1926: 203 (lapsus).
 Listronotus setosipennis; O’Brien, 1979: 268.
 Host plants. Parthenium hysterophorus L. (Asteraceae) (Wild et al., 1992).
 Distribution. Argentina, Brazil, and Uruguay (Wibmer and O'Brien, 1986).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 46, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
On the Nature of Angular Momentum Transport in Nonradiative Accretion Flows
Creators: name: Balbus, Steven A.
name: Hawley, John F.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The principles underlying a proposed class of black hole accretion models are examined. The flows are generally referred to as ``convection-dominated,'' and are characterized by inward transport of angular momentum by thermal convection and outward viscous transport, vanishing mass accretion, and vanishing local energy dissipation. We examine the viability of these ideas by explicitly calculating the leading order angular momentum transport of axisymmetric modes in magnetized, differentially rotating, stratified flows. The modes are destabilized by the generalized magnetorotational instability. There are no inward transporting modes at all unless the magnitude of the (imaginary) Brunt frequency is comparable to the epicyclic frequency, a condition requiring substantial levels of dissipation. When inward transporting modes do exist, they appear at long wavelengths, unencumbered by magnetic tension. Moreover, very general thermodynamic principles prohibit the complete recovery of irreversible dissipative energy losses, a central feature of convection-dominated models. Dissipation of the free energy of differential rotation inevitably requires outward angular momentum transport. Our results are in good agreement with global MHD simulations, which find significant levels of outward transport and energy dissipation, whether or not destabilizing entropy gradients are present.
description: To appear in ApJ v. 573, 14 pages, 2 figures, AAS Latex macros 4.0