cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Preclinical Formulation Development and Mechanistic Studies of Pluronic P123 JS-K
Creators: name: Kaur, Imit
Publisher: name: University of Utah
Year: 2014

description: The work in this dissertation summarizes the development of a nitric oxide producing prodrug, JS-K in a polymeric Pluronic® P123 micelle formulation. This work is an attempt to advance the formulation development and provide the preclinical rationale by studying: a) formulation stability and toxicity in vitro and in vivo and plasma protein binding of the drug and the formulation in vitro; b) cell distribution of the free drug (JSK) and the formulation (P123/JS-K) in vitro; c) mechanistic pathways triggered by JS-K and P123/JS-K leading to apoptosis and finally; d) development and validation of an analytical method for detection of the drug or formulation and biological metabolites when used in clinical settings. Except for the mechanistic studies performed where the method employed was Western blot or fluorescence analysis, all the other studies were conducted using analytical methods developed on high performance liquid chromatography (HPLC) equipped with ultra violet (UV) detector. The available method lacked metabolite detection and sensitivity with low drug concentration. Therefore, a more robust, sensitive and elaborate method was developed using ultra performance liquid chromatography (UPLC) equipped with a UV detector. The method was also validated as per United States Pharmacopoeia (USP). The validated method could be used for studying biodistribution, pharmacokinetics and potential toxicity in clinical settings. iv The major findings of the dissertation could be succinctly described by stating JS-K in the Pluronic P123 formulation was comparatively more stable than in the free-JS-K formulation. There was no major toxicity observed due to the designed formulation when tested both in vitro and in vivo. P123/JS-K showed preferential distribution in the cell nucleus, indicating some effect produced by the Pluronic® micelle. Mechanistically, not much difference was observed between JS-K and P123/JS-K and both were shown to produce stress response in leukemia cells. Both JS-K and P123/JS-K were nontoxic to CD34+ hematopoietic cells. The work described in this dissertation is an attempt to showcase "Bench to Bedside" research in laboratory settings. An attempt has been made to incorporate all the studies required by the regulatory agencies such as US Food and Drug Administration (FDA). The studies performed and the method developed will lay the platform for future studies that are required for filing an Investigational New Drug (IND) application following current Good Manufacturing Practices (cGMP).
Characterization of CD62L as a Marker of Hematopoietic Differentiation in Adult Mice
Creators: name: Cho, Hyung Jin (Scott)
Publisher: name: University of Utah
Year: 2014

description: The progression of early hematopoietic differentiation remains a topic of controversy. Topics of ongoing debate include the identification of a pure hematopoietic stem cell population and bifurcation of the lymphoid and myeloid lineages following commitment by multipotent progenitors. This dissertation contributes to the current knowledge of early hematopoietic differentiation and enhances the understanding of hematopoietic stem cell and progenitor biology by characterizing CD62L as a novel marker of early hematopoietic differentiation. Transplant studies revealed in vivo evidence for the existence of stem cell-containing CD62L- fraction and multipotent progenitor-containing CD62L+ fraction within the traditionally defined hematopoietic stem cell population. Sca-1 fractionation of the hematopoietic stem cell compartment demonstrated that cells of the Sca-1HIGH subset were almost homogeneous in their lack of CD62L expression. In contrast, the Sca-1LOW subset contained a heterogeneous mixture of CD62L+ and CD62L- cells. Engraftment analysis of the Sca-1LOW and Sca-1HIGH fractions demonstrated that the CD62L- cells of both Sca-1 fractions contained hematopoietic stem cells, with a higher frequency of stem cells within the Sca-1HIGH CD62L- fraction. Within the traditionally defined multipotent progenitor population, CD62L segregated a CD62L+ lymphoid-biased multipotent progenitor and a CD62L- multipotent progenitor with robust multipotency. Flow cytometric analysis of CD62L expression pattern within the multipotent progenitor population demonstrated that CD62L-based separation of progenitors was achieved independently of Flt3 expression. Lastly, the concomitant expression of CD62L and Flt3 revealed a rare population of v multipotent progenitors and a possible B cell/erythroid bipotent precursor within the previously demonstrated myeloid compartment. Simultaneous loss of CD62L and Flt3 was observed in the myeloid lineage-specific population. Together, these data demonstrate the expression of CD62L within the context of early hematopoietic differentiation and establish CD62L as a useful tool in the study of early hematopoiesis.
Modified Lomax Model: A heavy-tailed distribution for fitting large-scale real-world complex networks
Creators: name: Chattopadhyay, Swarup
name: Chakraborty, Tanujit
name: Ghosh, Kuntal
name: das, Asit K.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Real-world networks are generally claimed to be scale-free, meaning that the degree distributions follow the classical power-law, at least asymptotically. Yet, closer observation shows that the classical power-law distribution is often inadequate to meet the data characteristics due to the existence of a clearly identifiable non-linearity in the entire degree distribution in the log-log scale. The present paper proposes a new variant of the popular heavy-tailed Lomax distribution which we named as the Modified Lomax (MLM) distribution that can efficiently capture the crucial aspect of heavy-tailed behavior of the entire degree distribution of real-world complex networks. The proposed MLM model, derived from a hierarchical family of Lomax distributions, can efficiently fit the entire degree distribution of real-world networks without removing lower degree nodes as opposed to the classical power-law based fitting. The MLM distribution belongs to the maximum domain of attraction of the Frechet distribution and is right tail equivalent to Pareto distribution. Various statistical properties including characteristics of the maximum likelihood estimates and asymptotic distributions have also been derived for the proposed MLM model. Finally, the effectiveness of the proposed MLM model is demonstrated through rigorous experiments over fifty real-world complex networks from diverse applied domains.
Measurement of transforming growth factor beta one and extra domain A fibronectin gene transcription in rat acute glomerulonephritis by competitive polymerase chain reaction
Creators: name: Yu, Xiaohong
Publisher: name: University of Utah
Year: 2012
Subjects: DNA
RNA

description: The histologic picture of glomerulonephritis is characterized by pathological accumulation of extracellular matrix with damaged glomeruli.  Previous studies have demonstrated that increased production of mesangial matrix in rat acute glomerulonephritis is caused by increased expression of transforming growth factor beta one (TGHbeta1) messenger RNA.  The most popular method currently used in measuring mRNA levels is Northern blot.  An abundant RNA requirement (15-30 ug), however, restricts the application of Northern blot in which amounts of isolated RNA or tiny, such as in studies using human biopsies.  In this thesis project, a competitive PCR method has been developed to overcome the disadvantage of Northern blot.  The internal standards, PCR mimics, or TGFbeta1, extra domain A containing fibronectin (EDA fibronectin), and glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were synthesized using a PCR minmic™ construction kit from CLONTECH Laboratories, Inc.  They were applied as competitors of target cDNAs in measurement of the corresponding mRNA levels to correct the variations of PCR efficiency.  The variations of the efficiency of reverse transcription and the variations of the quantity and quality of mRNA samples were corrected by measuring the relative levels of gene expression using the ratios of target cDNA to G3PDH cDNA.  The specificity of this method was confirmed by DNA size measurement and Southern blot.  The detectable amount of specific mRNA was 10[-18) moles.  The amount of total mRNA applied was less than 100ng.  The accuracy verified by measuring the concentrations of DNA standards was 81%.  The precision confirmed by multiple measurements was 85%/  In rat acute glomerulonephritis, it was found that relative mRNA levels of TGFbeta1 started increasing on day 3(3.2-fold of normal), reached peak on day 7 (4.5-fold), and returned toward normal on day 14 (2.3-fold) and on day 21 (1.5-fold) post-ATS injection.  The relative levels of EDA fibronectin, however, remained normal on day 3 (1.2-fold of normal), increased profoundly on day 7 (79.9-fold), and returned toward normal on day 14 (21.9-fold) and on day 21 (6.7-fold) post-ATS injection.  The increase in TGFbeta1 and EDA fibronectin mRNA levels are significant except that in TGFbeta1 mRNA on day 21 and EDA fibronectin mRNA on day 3 and day 21.  The results were comparable with Northern blot data and further supported the previous conclusion the TGFbeta1 stimulated the expression of EDA fibronection in rat acute glomerulonephritis.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität nach einer Projektion vom 02.09.1965, erstellt von Max Waldmeier am Astrophysikalischen Observatorium Tschuggen in Arosa
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung am Astrophysikalischen Observatorium Tschuggen in Arosa. Instrument: Visuelles Objektiv an der Coelostatenanlage (15 cm Öffnung und 224 cm Brennweite, projiziertes Sonnenbild D = 25 cm). - Instrumentennachweis gemäss Tätigkeitsber. gedr. 1950 für das vorhergehende Jahr, S. 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen
Development of palladium-catalyzed difunctionalization reactions of 1,3-dienes and alkenes
Creators: name: Liao, Longyan
Publisher: name: University of Utah
Year: 2015
Subjects: 1,3-dienes
Difunctionalization
Palladium-catalyzed
Allylpalladium
Benzylpalladium
Terminal alkenes

description: Palladium (Pd)-catalyzed alkene difunctionalization reactions have been an active area of research in recent years. Expanding the diversity of alkene functionalization reactions to strategically impact the synthesis of small, complex molecules has been a long-standing area of interest for our group. In order to accomplish such transformations in palladium-catalyzed systems, the control of competing P-hydride elimination of Pd-alkyl intermediates must be achieved. One strategy employed to circumvent P-hydride elimination is substrate control via nallylpalladium or n-benzylpalladium intermediates, which may themselves be subsequently functionalized. Described below are several catalytic systems that we have developed based on this strategy to achieve the difunctionalization of 1,3-dienes and terminal alkenes. In the first chapter, an introduction to palladium-catalyzed alkene functionalization reactions utilizing substrate control via n-allylpalladium or n-benzylpalladium intermediates is presented. It is shown that these intermediates have been accessed in situ in a number of ways to facilitate non-Heck-type alkene functionalization reactions. In Chapter 2, our approach to the 1,2-hydroarylation of 1,3-dienes through the direct generation of n-allylpalladium intermediates via migratory insertion of 1,3-dienes into Pd-aryl species is described. Utilizing related strategies, the 1,2-vinylarylation (Chapter 3), and 1,2-diarylation (Chapter 4) of 1,3-dienes have been successfully developed. Additionally, by employing the generation of n-allylpalladium and n-benzylpalladium intermediates via hydride rearrangement, the 1,1-vinyarylation (Chapter 3) and 1,1-diarylation (Chapter 5) of simple alkenes have also been accomplished.
Sonnenfleckenzeichnung Nr. 21982.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.07.1965, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
A Systematic Literature Review to find out the Research Gap by identifying Factors affecting Relationship between Knowledge Management and Organizational Performance
Creators: name: Alam, Samsul
Publisher: name: Zenodo
Year: 2020
Subjects: factors identification
gap analysis
knowledge management
organizational performance
systematic literature review

description: This study aims at finding factors of knowledge management (KM) that affect organizational performance (OP). Thus, the study will suggest possible research agenda in the field of knowledge management. To find out the factors, a systematic literature review method is adopted. The result finds some research area in KM effect on all organizational performance indicators (E.g. cost/price, quality, delivery, responsiveness and flexibility, Business metrics, Total cost of ownership), complete KM impact on financial analysis of the organization that represents the OP (e.g. Ratio Analysis) appropriately; prepare a questionnaire and perform a survey to represent the relationship between KM and OP; perform hypothesis testing, factor analysis, correlation, and regression analysis and prepare graphs using SPSS Software for the best representation of the results; draw a reliable conclusion and summary that will guide the organizations towards the importance of knowledge management.
description: This is a working paper. To cite this paper use Alam, S. (2020, September 28). A Systematic Literature Review to find out the Research Gap by identifying Factors affecting Relationship between Knowledge Management and Organizational Performance. Zenodo. 1-18
MPEC 2024-M68 : 2017 DF165
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
clDice -- A Novel Topology-Preserving Loss Function for Tubular Structure Segmentation
Creators: name: Shit, Suprosanna
name: Paetzold, Johannes C.
name: Sekuboyina, Anjany
name: Ezhov, Ivan
name: Unger, Alexander
name: Zhylka, Andrey
name: Pluim, Josien P. W.
name: Bauer, Ulrich
name: Menze, Bjoern H.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Accurate segmentation of tubular, network-like structures, such as vessels, neurons, or roads, is relevant to many fields of research. For such structures, the topology is their most important characteristic; particularly preserving connectedness: in the case of vascular networks, missing a connected vessel entirely alters the blood-flow dynamics. We introduce a novel similarity measure termed centerlineDice (short clDice), which is calculated on the intersection of the segmentation masks and their (morphological) skeleta. We theoretically prove that clDice guarantees topology preservation up to homotopy equivalence for binary 2D and 3D segmentation. Extending this, we propose a computationally efficient, differentiable loss function (soft-clDice) for training arbitrary neural segmentation networks. We benchmark the soft-clDice loss on five public datasets, including vessels, roads and neurons (2D and 3D). Training on soft-clDice leads to segmentation with more accurate connectivity information, higher graph similarity, and better volumetric scores.
description: * The authors Suprosanna Shit and Johannes C. Paetzold contributed equally to the work
AI and IoT Meet Mobile Machines: Towards a Smart Working Site
Creators: name: Xiang, Yusheng
Publisher: name: KIT Scientific Publishing
Year: 2022
Subjects: Smart Working Site
Multi Working Machine Pathfinding Algorithm
Multivariable Time Series Classification Algorithm
SLAM
5G
IEEE 802.11p

description: Infrastructure construction is society's cornerstone and economics' catalyst. Therefore, improving mobile machinery's efficiency and reducing their cost of use have enormous economic benefits in the vast and growing construction market. In this thesis, I envision a novel concept smart working site to increase productivity through fleet management from multiple aspects and with Artificial Intelligence (AI) and Internet of Things (IoT).
Roles of Nkx2;2 and Ngn3 in vertebrate gliogenesis in the developing spinal cord
Creators: name: Lee, Jeffrey C.
Publisher: name: University of Utah
Year: 2012
Subjects: Growth
Central Nervous System

description: The vertebrate central nervous system (CNS) comprises of two types of cell:  neurons and glia.  In the developing vertebrate neural tube, glia consists of astrocytes, olegodendrocytes and radial glia.  Gliogenesis, the generation of glia, is a complex biological process that is necessary for proper nervous system function.  Among the molecular mechanisms that control gliogenesis are transcription factors.  Transcription factors are regulatory proteins that modulate gene expression and are therefore prime candidates to investigate in order to understand glial development.  Several studies have suggested that the ventral neural tube maybe the location from which oligodendrocyte precursors (OLPs) arise.  Several transcription factors are specifically expressed in the ventral neural tube and may direct glial specification.  To investigate whether such transcription factors may be required for the generation of olibodendrocytes and possible glia, mice harboring targeted delection of Nkx2.2 and Neurogenin3 (Ngn3), two transcription facators expressed in the ventral neural tube, were independently obtained and analyzed for a glial phenotype.  In both mice, oligodendrogliogenesis was compromised in the knockout animal but preserved in the wild-type control.  Furthermore, in transient transfection assays, both transcription factors were capable of driving gene expression from the proteolipid protein (PLP) promoter.  However, not all markers of OLP were affected.  In a subsequent study, the expression of astroglial markers was examined in the NKx2.2 and Ngn3 knockout animals.  In both mice, astroglial markers were affected.  In the Ngn3 mouse, there appeared to be less astrocyte marker expression in the knockout while an increase in radial glial marker expression was noted.  In the Nkx2.2 mouse, a decrease in the expression of radial glia markers was observed in the knockout animals.  In summary, Nkx2.2 and Ngn3 are required for the normal appearance of olgodendrocytes, astrocyetes and radial glia in the developing CNS and olgodendrocytes, astrocytes and radial glia likely share a common lineage.
Real-time forecasts and risk assessment of novel coronavirus (COVID-19) cases: A data-driven analysis
Creators: name: Chakraborty, Tanujit
name: Ghosh, Indrajit
Publisher: name: arXiv
Year: 2020
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: The coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern affecting 201 countries and territories around the globe. As of April 4, 2020, it has caused a pandemic outbreak with more than 11,16,643 confirmed infections and more than 59,170 reported deaths worldwide. The main focus of this paper is two-fold: (a) generating short term (real-time) forecasts of the future COVID-19 cases for multiple countries; (b) risk assessment (in terms of case fatality rate) of the novel COVID-19 for some profoundly affected countries by finding various important demographic characteristics of the countries along with some disease characteristics. To solve the first problem, we presented a hybrid approach based on autoregressive integrated moving average model and Wavelet-based forecasting model that can generate short-term (ten days ahead) forecasts of the number of daily confirmed cases for Canada, France, India, South Korea, and the UK. The predictions of the future outbreak for different countries will be useful for the effective allocation of health care resources and will act as an early-warning system for government policymakers. In the second problem, we applied an optimal regression tree algorithm to find essential causal variables that significantly affect the case fatality rates for different countries. This data-driven analysis will necessarily provide deep insights into the study of early risk assessments for 50 immensely affected countries.
Sonnenfleckenzeichnung Nr. 22009.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.08.1965, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Syndromic surveillance using search query logs and user location information from smartphones against COVID-19 clusters in Japan
Creators: name: Hisada, Shohei
name: Murayama, Taichi
name: Tsubouchi, Kota
name: Fujita, Sumio
name: Yada, Shuntaro
name: Wakamiya, Shoko
name: Aramaki, Eiji
Publisher: name: arXiv
Year: 2020
Subjects: subject: Information Retrieval (cs.IR)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: [Background] Two clusters of coronavirus disease 2019 (COVID-19) were confirmed in Hokkaido, Japan in February 2020. To capture the clusters, this study employs Web search query logs and user location information from smartphones. [Material and Methods] First, we anonymously identified smartphone users who used a Web search engine (Yahoo! JAPAN Search) for the COVID-19 or its symptoms via its companion application for smartphones (Yahoo Japan App). We regard these searchers as Web searchers who are suspicious of their own COVID-19 infection (WSSCI). Second, we extracted the location of the WSSCI via the smartphone application. The spatio-temporal distribution of the number of WSSCI are compared with the actual location of the known two clusters. [Result and Discussion] Before the early stage of the cluster development, we could confirm several WSSCI, which demonstrated the basic feasibility of our WSSCI-based approach. However, it is accurate only in the early stage, and it was biased after the public announcement of the cluster development. For the case where the other cluster-related resources, such as fine-grained population statistics, are not available, the proposed metric would be helpful to catch the hint of emerging clusters.
KIVI: A Tuning-Free Asymmetric 2bit Quantization for KV Cache
Creators: name: Liu, Zirui
name: Yuan, Jiayi
name: Jin, Hongye
name: Zhong, Shaochen
name: Xu, Zhaozhuo
name: Braverman, Vladimir
name: Chen, Beidi
name: Hu, Xia
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences

description: Efficiently serving large language models (LLMs) requires batching of many requests to reduce the cost per request. Yet, with larger batch sizes and longer context lengths, the key-value (KV) cache, which stores attention keys and values to avoid re-computations, significantly increases memory demands and becomes the new bottleneck in speed and memory usage. Additionally, the loading of the KV cache causes the computational core to be idle, which limits the inference speed. A straightforward and effective solution to reduce KV cache size is quantization, which decreases the total bytes taken by KV cache. However, there is a lack of in-depth studies that explore the element distribution of KV cache to understand the hardness and limitation of KV cache quantization. To fill the gap, we conducted a comprehensive study on the element distribution in KV cache of popular LLMs. Our findings indicate that the key cache should be quantized per-channel, i.e., group elements along the channel dimension and quantize them together. In contrast, the value cache should be quantized per-token. From this analysis, we developed a tuning-free 2bit KV cache quantization algorithm named KIVI. With hardware-friendly implementation, KIVI can enable Llama, Falcon, and Mistral models to maintain almost the same quality while using $\mathbf{2.6\times}$ less peak memory (including model weight). This reduction in memory usage enables up to $\mathbf{4\times}$ larger batch size, bringing $\mathbf{2.35\times \sim 3.47\times}$ throughput on real LLM inference workload. The source code is available at https://github.com/jy-yuan/KIVI.
description: ICML2024
On Some Operators Associated with Non-Degenerate Symmetric $α$-Stable Probability Measures
Creators: name: Arras, Benjamin
name: Houdré, Christian
Publisher: name: arXiv
Year: 2020
Subjects: subject: Probability (math.PR)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 42B20, 60E07, 42B15, 26A33

description: Boundedness properties of operators associated with non-degenerate symmetric $α$-stable, $α\in (1,2)$, probability measures on $\mathbb{R}^d$ are investigated on appropriate, Euclidean or otherwise, $L^p$-spaces, $p \in (1,+\infty)$. Our approach is based on first obtaining Bismut-type formulae which lead to useful representations for various operators. In the Euclidean setting, the method of transference and one-dimensional multiplier theory combined with fine properties of stable distributions provide dimension-free estimates for the fractional Laplacian. In the non-Euclidean setting, we obtain boundedness results for the non-singular cases as well as dimension-free estimates when the reference measure is the rotationally invariant $α$-stable probability measure.
description: 53 pages
The Louse Fly-Arsenophonus Arthropodicus association: development of a new model system for the study of insect-bacterial endosymbioses
Creators: name: Smith, Kari Lyn
Publisher: name: University of Utah
Year: 2015
Subjects: Arsenophonus arthropodicus
Endosymbiosis
Evolution
Genomics
Pseudolynchia canariensis
Symbiont transmission

description: There are many bacteria that associate with insects in a mutualistic manner and offer their hosts distinct fitness advantages, and thus have likely played an important role in shaping the ecology and evolution of insects. Therefore, there is much interest in understanding how these relationships are initiated and maintained and the molecular mechanisms involved in this process, as well as interest in developing symbionts as platforms for paratransgenesis to combat disease transmission by insect hosts. However, this research has been hampered by having only a limited number of systems to work with, due to the difficulties in isolating and modifying bacterial symbionts in the lab. In this dissertation, I present my work in developing a recently described insect-bacterial symbiosis, that of the louse fly, Pseudolynchia canariensis, and its bacterial symbiont, Candidatus Arsenophonus arthropodicus, into a new model system with which to investigate the mechanisms and evolution of symbiosis. This included generating and analyzing the complete genome sequence of Ca. A. arthropodicus, which provided some evidence that Ca. A. arthropodicus has become recently associated with insects and may have evolved from an ancestor that was an insect pathogen. Additionally, I describe the development of methods for genetic modification of this bacterial symbiont and for introducing recombinant symbionts into louse fly hosts, as well as a new microinjection technique that enables the complete replacement of native symbionts with recombinant symbionts. With the generation of the symbiont genome sequence along with strategies for engineering recombinant symbionts and establishing them in an insect host, this work provides an interesting new system with which to investigate the function of specific genes in symbiosis as well as a promising new avenue of research involving paratransgenesis.
Sonnenfleckenzeichnung Nr. 22026.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.08.1965, erstellt von Berthold Hermes
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Nicotinic Acetylcholine Receptor Expression in Rat Dorsal Root Ganglion Neurons
Creators: name: Hone, John Charles
Publisher: name: University of Utah
Year: 2014

description: Dorsal root ganglia (DRG) contain neurons whose axons convey somatosensory information, including pain, from the periphery to the central nervous system (CNS). These neurons are known to express a variety of nicotinic acetylcholine receptors (nAChR), including those that are being investigated as therapeutic targets for the treatment of chronic and neuropathic pain syndromes. Previous reports indicate that rat DRG neurons express nAChRs consistent with an α3β4*-, α4β2*-, and α7-like composition (*, denotes the possible presence of additional subunits). However, transcripts for other nAChR subunits including α6, α9, and α10 have also been reported. Therefore, additional nAChR subtypes with these subunits were hypothesized to also be expressed. In this dissertation, reverse-transcription polymerase chain-reaction (RT-PCR) was used to identify transcripts for the nAChR subunits present in dissociated lumbar DRG neurons from rat. Pharmacological characterization of acetylcholine-gated currents (IACh) was performed using whole-cell patch-clamp electrophysiology. Individual nAChR subtypes were identified using novel subtype-selective α-conotoxins (α-Ctxs). The results of these experiments demonstrate for the first time the presence of α6β4* nAChRs in neurons outside the CNS and, in particular, in DRG neurons. No evidence was found for IACh mediated by nAChRs containing the α9 subunit. Chapter 1 begins with an overview of nAChRs and a review of the current literature concerning the expression of nAChRs by DRG neurons. The experimental results of this investigation are reported in Chapter 2. iv Lastly, in Chapter 3, the implications of these findings are discussed in the context of treatment of pain syndromes by ligands that target nAChRs.
Sonnenfleckenzeichnung Nr. 21993.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.07.1965, erstellt von Berthold Hermes
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Black Hole Metamorphosis and Stabilization by Memory Burden
Creators: name: Dvali, Gia
name: Eisemann, Lukas
name: Michel, Marco
name: Zell, Sebastian
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Systems of enhanced memory capacity are subjected to a universal effect of memory burden, which suppresses their decay. In this paper, we study a prototype model to show that memory burden can be overcome by rewriting stored quantum information from one set of degrees of freedom to another one. However, due to a suppressed rate of rewriting, the evolution becomes extremely slow compared to the initial stage. Applied to black holes, this predicts a metamorphosis, including a drastic deviation from Hawking evaporation, at the latest after losing half of the mass. This raises a tantalizing question about the fate of a black hole. As two likely options, it can either become extremely long lived or decay via a new classical instability into gravitational lumps. The first option would open up a new window for small primordial black holes as viable dark matter candidates.
description: 24 pages (2 column), 8 figures, 1 appendix; v2: added discussions of analytic understanding of our result (section III.C) and of role of number non-conservation (section IV) as well as minor improvements, matches published version; v3: added link to numerical data, minor updates of references and plots
A review of opioid use for pain in adult patients with traumatic injuries
Creators: name: Durling-Grover, Renay
Publisher: name: No Publisher Supplied
Year: 2020

description: Purpose: To evaluate the impact and effectiveness of New Jersey (NJ) Senate Bill 3 in reducing the use of opioids in the treatment of pain for the trauma patient in the inpatient setting. The goal of this project was to examine the prescribing practices of practitioners and the patients use of opioid pain medications in the hospital setting prior to, and after the enactment of Senate Bill 3. Methodology: This project was a single center retrospective review which took place at an American College of Surgeons verified Level I Trauma Center in NJ. In all, a total of 2,043 patient charts for calendar years 2016 and 2018 were reviewed. Injury Severity Score (ISS) and Morphine Milligram Equivalents (MME) were recorded by patient and the data between the two years was compared to ascertain opioid consumption pre and post the Senate Bill enactment. Patients prescribe opioid drips, methadone, or fentanyl patches were excluded because the data available did not allow for accurate conversion to MME. After applying these exclusion criteria, a total of 1,688 patients charts remained. Results: The average daily MME consumption dropped from 14.1±0.48 MME/day in 2016 to 8.78±0.33 MME/day in 2018. This represents a 38% decrease with p<0.001 in inpatient opioid use over a similar length of stay (LOS, 4.34±0.14 versus 4.41±0.13 days) of patients in both years. The total MME consumed per person decreased form 77.0 MME/stay to 44.8 MME/stay, a nearly 42% decrease in opioid consumption during inpatient treatment. While the injury severity score (ISS) of patients was higher in 2018 than in 2016 (10.6±0.21 vs. 9.09±0.19, p<0.001) still less opioid was used in 2018. Also, trauma patients in 2018 were approximately 4.2 years older than in 2016 (59.9±0.69 years in 2018 vs. 55.7 ±0.71 years in 2016, p<0.001). Implications for Practice: This retrospective review demonstrated that one single entity cannot correct a multi-tiered societal problem. Medical professionals, legislators, community leaders, and the community itself must work in a collaborative fashion to employ meaningful and multifaceted solutions to solve the opioid crisis.
Galois representations on the cohomology of hyper-Kähler varieties
Creators: name: Floccari, Salvatore
Publisher: name: arXiv
Year: 2020
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14C30, 14F20, 14J20, 14J32

description: We show that the André motive of a hyper-Kähler variety $X$ over a field $K \subset \mathbb{C}$ with $b_2(X)>6$ is governed by its component in degree $2$. More precisely, we prove that if $X_1$ and $X_2$ are deformation equivalent hyper-Kähler varieties with $b_2(X_i)>6$ and if there exists a Hodge isometry $f\colon H^2(X_1,\mathbb{Q})\to H^2(X_2,\mathbb{Q})$, then the André motives of $X_1$ and $X_2$ are isomorphic after a finite extension of $K$, up to an additional technical assumption in presence of non-trivial odd cohomology. As a consequence, the Galois representations on the étale cohomology of $X_1$ and $X_2$ are isomorphic as well. We prove a similar result for varieties over a finite field which can be lifted to hyper-Kähler varieties for which the Mumford--Tate conjecture is true.
description: added Section 5; accepted for publication in Math. Zeit
Chain-of-Layer: Iteratively Prompting Large Language Models for Taxonomy Induction from Limited Examples
Creators: name: Zeng, Qingkai
name: Bai, Yuyang
name: Tan, Zhaoxuan
name: Feng, Shangbin
name: Liang, Zhenwen
name: Zhang, Zhihan
name: Jiang, Meng
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Automatic taxonomy induction is crucial for web search, recommendation systems, and question answering. Manual curation of taxonomies is expensive in terms of human effort, making automatic taxonomy construction highly desirable. In this work, we introduce Chain-of-Layer which is an in-context learning framework designed to induct taxonomies from a given set of entities. Chain-of-Layer breaks down the task into selecting relevant candidate entities in each layer and gradually building the taxonomy from top to bottom. To minimize errors, we introduce the Ensemble-based Ranking Filter to reduce the hallucinated content generated at each iteration. Through extensive experiments, we demonstrate that Chain-of-Layer achieves state-of-the-art performance on four real-world benchmarks.
Factors related to parent provision of sexuality education for youth with asperger's disorder and high functioning autism
Creators: name: Holmes, Laura Graham
Publisher: name: University of Utah
Year: 2014
Subjects: Adolescence
Autism spectrum disorders
Puberty
Sexuality
Sexuality education

description: This study examined the relationship between autism spectrum disorder (ASD) symptoms, parental romantic expectations, and parental provision of sexuality education in a sample of 120 parents of youth aged 12-18 years who were diagnosed with ASD by a healthcare professional. Regression analyses showed that overall ASD symptoms predicted parental romantic expectations, but did not predict parental provision of sexuality education. Secondary analyses using simple linear regression showed that specific ASD symptoms (i.e., social motivation and social cognition) predicted a small amount of variance in parental provision of sex education. Additionally, exploratory regression analyses identified other factors related to parent provision of sex education for youth with ASD. Parents who rated themselves as more effective regarding their ability to communicate with their children about sexuality and parents who rated themselves as more prepared to manage their child's sexual development covered a greater number of sexuality-related topics with their child. The results of the current study have implications for the development of interventions to promote effective sexuality communication and positive sexual health outcomes for youth with ASD.
Sonnenfleckenzeichnung Nr. 21960.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.06.1965, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Genetic effects of occupational exposure to styrene as measured using the micronucleus test
Creators: name: Blumer, Michael Kevin
Publisher: name: University of Utah
Year: 2012
Subjects: Adverse Effects
Fiberglass Fabrication

description: Styrene has been shown to be mutagenic upon metabolic activation. However, studies of occupationally exposed populations have shown conflicting results when looking for chromosomal effects. The present study was conducted to help determine the chromosomal effects of occupational exposure to styrene. Lymphocyte micronuclei were used as indicators of chromosomal breakage.  Eight exposed subjects involved in fiberglass fabrication and six matched controls from a metal fabrication company were studied. Styrene exposure was measured using an infrared analyzer and passive organic vapor monitors. Actual styrene dosage and metabolism was documented with end-of-shift urinary mandelic acid measurements. Lifetime styrene exposure was calculated from questionnaire data. Micronuclei were counted in lymphocytes with intact cytoplasm.  The exposed subjects showed an increase in lymphocyte micronuclei, but the increase was not statistically significant. No dose response relationship was found between current styrene exposure and micronucleus levels, mandelic acid and micronucleus levels, or lifetime styrene exposure and micronucleus levels.
Sonnenfleckenzeichnung Nr. 22068.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.10.1965, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Random Field Ising Model and Parisi-Sourlas Supersymmetry. Part II. Renormalization Group
Creators: name: Kaviraj, Apratim
name: Rychkov, Slava
name: Trevisani, Emilio
Publisher: name: arXiv
Year: 2020
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revisit perturbative RG analysis in the replicated Landau-Ginzburg description of the Random Field Ising Model near the upper critical dimension 6. Working in a field basis with manifest vicinity to a weakly-coupled Parisi-Sourlas supersymmetric fixed point (Cardy, 1985), we look for interactions which may destabilize the SUSY RG flow and lead to the loss of dimensional reduction. This problem is reduced to studying the anomalous dimensions of "leaders" -- lowest dimension parts of $S_n$-invariant perturbations in the Cardy basis. Leader operators are classified as non-susy-writable, susy-writable or susy-null depending on their symmetry. Susy-writable leaders are additionally classified as belonging to superprimary multiplets transforming in particular $\textrm{OSp}(d | 2)$ representations. We enumerate all leaders up to 6d dimension $Δ= 12$, and compute their perturbative anomalous dimensions (up to two loops). We thus identify two perturbations (with susy-null and non-susy-writable leaders) becoming relevant below a critical dimension $d_c \approx 4.2$ - $4.7$. This supports the scenario that the SUSY fixed point exists for all $3 < d \leq 6$, but becomes unstable for $d < d_c$.
description: 103 pages, 15 figures. v2: susy-null leader discussion modified (Sec. 8.5 and App. A.6), and other tweaks. v3: version accepted by JHEP, added executive summary in Sec. 1.1, discussion in Sec 11.1.1 and Sec. 11.2.1, corrected typos. v4: corrected typos. Conclusions unchanged
Sonnenfleckenzeichnung Nr. 22048.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 24.09.1965, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1965

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel