title: ÐÐ°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ¾Ð² Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ° Ð½Ð° ÐºÐ¸Ð½ÐµÑÐ¸ÐºÑ ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¾ÐºÐ° Ð² ÐºÐ¾ÑÐºÐ¾Ð²ÑÑ Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Mathematical model of the influence of glutamate transporters on the kinetics of synaptic current in cork neurons
Creators: name: ÐÐ¾Ð»ÑÐ±ÐµÐ²Ð°, ÐÐ°ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð³Ð»ÑÑÐ°Ð¼Ð°Ñ
EAAT2
AMPA
NMDA
Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
epilepsy
glutamate
mathematical modeling

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²ÐºÐ»Ð°Ð´Ð° ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ° Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ° EAAT2 Ð² ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾ÑÑÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ²ÐµÑÐ°. ÐÐ°Ð´Ð°ÑÐ¸, ÑÐµÑÐ°Ð²ÑÐ¸ÐµÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: 1. ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ Ð¿Ð¾ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµ-ÑÐºÐ¾Ð¼Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð² Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÑÐµÑÐµ. 2. ÐÑÑÐ²Ð»ÐµÐ½Ð¸Ðµ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐµÐ¹, Ð½Ðµ ÑÑÑÐµÐ½Ð½ÑÑ Ð² Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÑ, ÑÐ¾-Ð·Ð´Ð°Ð½Ð½ÑÑ ÑÐ°Ð½ÐµÐµ. 3. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸ ÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸. Ð Ð°Ð±Ð¾ÑÐ° Ð²ÑÐ¿Ð¾Ð»Ð½ÑÐ»Ð°ÑÑ Ð² Ð¤Ð¸Ð·Ð¸ÐºÐ¾-ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð¼ Ð¸Ð½ÑÑÐ¸ÑÑÑÐµ Ð¸Ð¼ÐµÐ½Ð¸ Ð. Ð¤. ÐÐ¾ÑÑÐµ Ð ÐÐ, Ð³Ð´Ðµ Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð², Ð¿ÑÐµÐ´Ð¾ÑÑÐ°Ð²-Ð»ÐµÐ½Ð½ÑÑ Ð¸Ð½ÑÑÐ¸ÑÑÑÐ¾Ð¼ ÑÐ²Ð¾Ð»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸Ð¸ Ð¸Ð¼ÐµÐ½Ð¸ Ð. Ð. Ð¡ÐµÑÐµ-Ð½Ð¾Ð²Ð° Ð ÐÐ, Ð±ÑÐ»Ð° ÑÐ¾Ð·Ð´Ð°Ð½Ð° Ð½Ð¾Ð²Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ, Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÑÑÐ°Ñ Ð²ÐºÐ»Ð°Ð´ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ° EAAT2 Ð² ÑÐ°Ð±Ð¾ÑÑ Ð¿ÑÐ¾Ð²Ð¾Ð´ÑÑÐ¸Ñ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ° AMPA Ð¸ NMDA. ÐÑÐ¸ Ð¿Ð¾Ð¼Ð¾ÑÐ¸ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¹ Ð¸ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¾ÑÐµÑÑÑ Ð±ÑÑÑÑÐ¾Ð³Ð¾ ÑÐ´Ð°Ð»ÐµÐ½Ð¸Ñ Ð³Ð»ÑÑÐ°Ð¼Ð°ÑÐ° Ð¸Ð· ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÐ»Ð¸ Ð¿Ð¾ÑÑÐµÐ´ÑÑÐ²Ð¾Ð¼ Ð´Ð¸ÑÑÑÐ·Ð¸Ð¸ Ð¸ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐµÐ³Ð¾ ÑÐ´Ð°Ð»ÐµÐ½Ð¸Ñ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ¾Ð¼ Ð¸Ð· ÑÐºÑÑÑÐ°ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÑÑÐ°Ð½ÑÑÐ²Ð° Ð¸Ð³ÑÐ°ÑÑ ÐºÐ»ÑÑÐµÐ²ÑÑ ÑÐ¾Ð»Ñ Ð² ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ¸Ð½Ð°Ð¿ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ²ÐµÑÐ°. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°-Ð±Ð¾ÑÑ Ð¼Ð¾Ð³ÑÑ Ð½Ð°Ð¹ÑÐ¸ ÑÐ¸ÑÐ¾ÐºÐ¾Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÐºÐ°Ðº Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð½ÐµÐ¹ÑÐ¾ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸, Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑÑÑ Ð´Ð»Ñ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð¸Ñ Ð¸Ð»Ð¸ Ð¾Ð¿ÑÐ¾Ð²ÐµÑÐ¶ÐµÐ½Ð¸Ñ Ð³Ð¸Ð¿Ð¾ÑÐµÐ·, ÑÐ°Ðº Ð¸ Ð´Ð»Ñ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»ÑÐ½ÑÑ Ð½ÐµÐ¹ÑÐ¾ÑÐµÑÐµÐ¹, Ð² ÐºÐ¾ÑÐ¾ÑÑÑ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÐ¸ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² ÑÐ²Ð»ÑÑÑÑÑ ÐºÐ»ÑÑÐµÐ²ÑÐ¼Ð¸.
description: This work is devoted to study the contribution of the EAAT2 glutamate trans-porter to the formation of the postsynaptic response. Tasks solved during the study are following: 1. The study of literature on neurophysiology and mathematical modeling in this area. 2. Identification of features is not considered in mathematical models created earlier. 3. Development and formulation of a new mathematical model. The work was carried out at the A. F. Ioffe Physical-Technical Institute of the Russian Academy of Sciences, where theoretical and experimental data were pro-cessed, and based on an analysis of existing models and experiments provided by the Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, a new model describing the contribution of EAAT2 to the ac-tivity of AMPA and NMDA receptors was built. It was shown that the processes of rapid removal of glutamate from the synaptic cleft by diffusion and subsequent elimination from extracellular space through the EAAT2, play a pivotal role in the for-mation of the synaptic response. The results of this work can be widely used both in the field of neurophysiology, used to confirm or refute hypotheses, and to build model neural networks in which the equations of conduction are key.