cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Femtosecond pulsed light polarization induced effects in direct laser writing 3D nanolithography
Creators: name: Malinauskas, Mangirdas
name: Rekštyte, Sima
name: Jonavicius, Tomas
name: Gailevicius, Darius
name: Mizeikis, Vygantas
name: Gamaly, Eugene
name: Juodkazis, Saulius
name: Klotzbach, Udo
name: Washio, Kunihiko
name: Arnold, Craig B.
Publisher: name: Swinburne
Year: 2024

description: We demonstrate how the coupling between (i) polarization of the writing laser beam, (ii) tight focusing and (iii) heat conduction affects the size, shape and absorption in the laser-affected area and therefore the polymerization process. It is possible to control the sizes of 3D laser-produced structure at the scale of several nanometers. Specifically we were able to tune the aspect ratio of 3D suspended line up to 20% in hybrid SZ2080 resist. The focal spot of tightly focused linearly polarized beam has an elliptical form with the long axis in the field direction. It is shown here that this effect is enhanced by increase in the electronic heat conduction when polarization coincide with temperature gradient along with the absorption. Overlapping of three effects (i- iii) results in the difference of several tens of nanometers between two axes of the focal ellipse. Narrow line appears when polarization and scan direction coincide, while the wide line is produced when these directions are perpendicular to each other. The effect scales with the laser intensity giving a possibility to control the width of the structure on nanometer scale as demonstrated experimentally in this work. These effects are of general nature and can be observed in any laser-matter interaction experiments where plasma produced by using tight focusing of linear-polarized light.
A microelectromechanical system artificial basilar membrane based on a piezoelectric cantilever array and its characterization using an animal model
Creators: name: Jang, Jongmoon
name: Lee, Jangwoo
name: Woo, Seongyong
name: Sly, David
name: Campbell, Luke J.
name: Cho, Jin Ho
name: O'Leary, Stephen J.
name: Park, Min Hyun
name: Han, Sungmin
name: Choi, Ji Wong
name: Hun Jang, Jeong
name: Choi, Hongsoo
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 320217
subject: Otorhinolaryngology
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 400309
subject: Neural engineering

description: We proposed a piezoelectric artificial basilar membrane (ABM) composed of a microelectromechanical system cantilever array. The ABM mimics the tonotopy of the cochlea: frequency selectivity and mechanoelectric transduction. The fabricated ABM exhibits a clear tonotopy in an audible frequency range (2.92-12.6 kHz). Also, an animal model was used to verify the characteristics of the ABM as a front end for potential cochlear implant applications. For this, a signal processor was used to convert the piezoelectric output from the ABM to an electrical stimulus for auditory neurons. The electrical stimulus for auditory neurons was delivered through an implanted intra-cochlear electrode array. The amplitude of the electrical stimulus was modulated in the range of 0.15 to 3.5 V with incoming sound pressure levels (SPL) of 70.1 to 94.8 dB SPL. The electrical stimulus was used to elicit an electrically evoked auditory brainstem response (EABR) from deafened guinea pigs. EABRs were successfully measured and their magnitude increased upon application of acoustic stimuli from 75 to 95 dB SPL. The frequency selectivity of the ABM was estimated by measuring the magnitude of EABRs while applying sound pressure at the resonance and off-resonance frequencies of the corresponding cantilever of the selected channel. In this study, we demonstrated a novel piezoelectric ABM and verified its characteristics by measuring EABRs.
Node activity scheduling schemes in large-scale wireless sensor networks
Creators: name: Tian, Di
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Computer Science.

description: In wireless sensor networks that consist of a large number of low-power, short-lived, unreliable sensors, one of the main design challenges is to obtain long system lifetime without sacrificing sensing quality; i.e. sensing coverage in this context. In this thesis, we first propose a node-scheduling scheme, which can reduce system overall energy consumption, therefore increasing system lifetime, by identifying redundant nodes with respect to sensing coverage and then assigning them an off duty operation mode which has lower energy consumption than the normal on-duty mode. Our scheme aims at completely preserving original sensing coverage. Practically, sensing coverage degradation caused by location error, packet loss and node failure is very limited, not more than 1%, as shown by our experimental results. We implement the proposed scheme in NS-2, as an extension of the LEACH protocol and compare its energy consumption with the original LEACH. Simulation results exhibit noticeably longer system lifetime with our scheme as compared to earlier algorithm. The first scheme we propose aims at completely preserving sensing coverage. This, however, requires each node to get, in some way, the knowledge of its own and its neighbors' location information. Also, in that scheme, each node has to perform some calculations to determine whether to take an off-duty status. To alleviate these restrictions, we propose and study several alternative node-scheduling schemes, which cannot guarantee the complete preservation of the original system coverage, but are nonetheless more light-weighted and flexible than the previous one. The simulation results compare these schemes with the previous one and demonstrate their effectiveness. In a single wireless sensor network, sensors are performing two operations: sensing and communication. Therefore, there might exist two kinds of redundancy in the network. Most of the previous work addressed only one kind of redundancy: sensing or communication alone. Although there have been research efforts trying to combine consideration of coverage and connectivity maintenance in a single activity scheduling, their theoretical basis for safe scheduling integration condition is only applicable in those networks that are initially fully covered by sensors. Random node deployment often makes initial sensing holes inside the deployed area inevitable, even in an extremely high-density network. Therefore, in this thesis, we enhance these works to support general wireless sensor networks by proving another conclusion: "the communication range is twice the sensing range" is the sufficient condition and the tight lower bound to ensure that complete coverage preservation implies connectivity among active nodes, if the original network topology (consisting of all the deployed nodes) is connected. Also, we extend the results to k-degree network connectivity and k-degree coverage preservation.
title: "It's never taught that way"
title: comics as a medium for anti-oppressive pedagogies in English language arts and literacy education
titleType: Subtitle
Creators: name: Amato, Nicole Ann
Publisher: name: University of Iowa
Year: 2023
Subjects: Anti-Oppressive Pedagogy
Comics
Graphic Novels
Young Adult Literature
public abstract
English Education
Teacher Education

description: This three-article dissertation examines the role of comics as a medium for developing anti-oppressive pedagogies with teacher educators and teacher candidates in English language Arts (ELA) and literacy education. Using methods of critical content analysis (Johnson et al, 2016), descriptive qualitative research (Merriam & Tisdell, 2016), and (post)qualitative analysis (Jackson & Mazzei, 2012), I conducted three studies to consider the following broad research question: In what ways can comics support teacher candidates in pursuit of anti-oppressive ELA curriculum and pedagogy? Drawing on Kumashiro’s (2000; 2001; 2002; 2009) framework for anti-oppressive education, theories of multimodality (New London Group, 1996; Kress & van Leeuwen, 1996; Sousanis, 2015), and sociocultural theories of reader response (Smagorinsky, 2001; Lewis et al, 2007; Park, 2012; Enciso, 2021), my analysis illuminates how one teacher educator and a group of teacher candidates at a Midwestern university pursued and developed anti-oppressive stances while reading and responding to young adult literature (YAL). For the first article, I conducted a content analysis of texts marketed to youth to explore how representations of fatphobia within comics differed from representations of fatphobia in prose. For the second and third articles, I conducted descriptive qualitative research of teacher candidates in the context of a monthly book club. For the second article, I analyzed teacher candidates' responses to YAL and comics about fatphobia. For the third article, I analyzed teacher candidates’ response to comics marketed to queer youth of Color. I took an ethnographic approach to data collection; and I used qualitative analytic methods to analyze within and across multiple data sources, including audio- and video- recordings, transcription, impromptu interviews, artifacts, memos, and field notes.
description: Analysis from this dissertation builds on existing empirical research that examines how teacher educators use YAL and comics as a necessary medium for teacher educators and teacher candidates in pursuit of anti-oppressive pedagogies. In response to my research question, I report that the medium of comics, when read and discussed collaboratively, are uniquely able to disrupt dominant narratives, reposition privileged readers as critical outsiders, and encourage self-reflexive talk and thinking. Findings from this study demonstrate how teacher educators and teacher candidates within ELA and Literacy Education might use comics to curate texts for curriculum and develop discussion-based classrooms rooted in anti-oppressive pedagogies.
Interactive translation vs pre-translation in the context of translation memory systems: Investigating the effects of translation method on productivity, quality and translator satisfaction
Creators: name: Wallis, Julian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Language, General.

description: Translation Memory (TM) systems are currently among the most popular translation tools available on the market. Clients today are looking for productivity and quality, but at the same time are looking to reduce costs. A TM stores portions of previously translated texts in a database so that they can be reused in new texts. There are two ways of working with a TM: interactive mode and pre-translation mode. In interactive mode, the TM system offers proposals to the translator, who can choose to accept and adapt them, or refuse them and translate from scratch. In pre-translation mode, the TM system's proposals are automatically inserted into the new source text, producing a hybrid text containing a mixture of source and target language elements. The translator's job is then to verify the translation of the automatically replaced portions of text, as well as to translate any text that was left in the source language. As the demand for translation continues to rise, more and more translators are looking to TMs to help increase productivity; however, for a variety of reasons, such as cost and incompatible file formats, they do not always have access to a useful TM. Therefore, translators need access to the TM database of the client they are working for in order to complete their translations. However, clients are increasingly hesitant to give out their databases due to proprietary issues. For this reason, many clients are turning to the pre-translation option so that they can get their translations done without having to give out their TM databases. To date, however, no one has yet studied whether the choice of pre-translation vs. interactive translation has an effect on productivity, quality and translator satisfaction. This thesis aims to go some way towards filling this gap by designing and testing a methodology to compare these two methods of working with a TM system. The thesis is divided into three main parts. Part I provides background information on TMs through a literature survey, the findings of which form the basis for three hypotheses concerning the ways in which interactive and pre-translation will impact translation productivity and quality, as well as translator satisfaction. Part II describes an experiment that was designed and conducted to investigate these hypotheses. Finally, Part III evaluates the research carried out in this thesis and suggests possible ways to expand it in the future.
Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex
Creators: name: Angamo, Eskedar Ayele
name: Ul Haq, Rizwan
name: Roesner, Joerg
name: Gabriel, Siegrun
name: Gerevich, Zoltan
name: Heinemann, Uwe
name: Kovacs, Richard
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: lactate
subject: monocarboxylate transporter inhibitors
subject: seizure
subject: interictal activity
subject: mesial temporal lobe epilepsy
subject: adenosine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Neuronal lactate uptake supports energy metabolism associated with synaptic signaling and recovery of extracellular ion gradients following neuronal activation. Altered expression of the monocarboxylate transporters (MCT) in temporal lobe epilepsy (TLE) hampers lactate removal into the bloodstream. The resulting increase in parenchymal lactate levels might exert both, anti- and pro-ictogen effects, by causing acidosis and by supplementing energy metabolism, respectively. Hence, we assessed the contribution of lactate to the maintenance of transmembrane potassium gradients, synaptic signaling and pathological network activity in chronic epileptic human tissue. Stimulus induced and spontaneous field potentials and extracellular potassium concentration changes (∆[K+]O) were recorded in parallel with tissue pO2 and pH in slices from TLE patients while blocking MCTs by α-cyano-4-hydroxycinnamic acid (4-CIN) or d-lactate. Intrinsic lactate contributed to the oxidative energy metabolism in chronic epileptic tissue as revealed by the changes in pO2 following blockade of lactate uptake. However, unlike the results in rat hippocampus, ∆[K+]O recovery kinetics and field potential amplitude did not depend on the presence of lactate. Remarkably, inhibition of lactate uptake exerted pH-independent anti-seizure effects both in healthy rat and chronic epileptic tissue and this effect was partly mediated via adenosine 1 receptor activation following decreased oxidative metabolism. View Full-Text
Effects of the HIV-1 protease inhibitor ritonavir on preadipocyte differentiation.
Creators: name: Nguyen, Anh Thu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Health Sciences, Pharmacology.

description: HIV-1 protease inhibitor therapy is associated with a novel lipodystrophy syndrome characterized by truncal adiposity, peripheral fat atrophy, dyslipidemia, and type 2 diabetes. The increase in truncal fat may be due to increase in adipocyte number as a result of enhanced preadipocyte differentiation. We show that addition of 10 mug/ml ritonavir to standard differentiation medium enhanced 3T3-L1 preadipocyte differentiation as measured by a 30% increase in triacylglycerol (TG) accumulation and a 50% increase in glycerol 3-phosphate dehydrogenase (GPDH) activity. Although ritonavir partially inhibited protein expression of peroxisome proliferator activated receptor gamma (PPARgamma), CCAAT/enhancer binding protein alpha (C/EBPalpha), and the aP2 gene (which encodes the adipocyte lipid binding protein), it resulted in higher levels of the active form of adipocyte determination and differentiation-dependent factor-1 (ADD-1), also known as sterol regulatory element binding protein 1 (SREBP-1). The enhancing effects of ritonavir on late events of 3T3-L1 preadipocyte differentiation may be mediated by ADD-1/SREBP-1 which has been shown to directly activate transcription of several genes encoding lipogenic enzymes. Preliminary results suggest that ritonavir preferentially enhances differentiation of human preadipocytes derived from abdominal omental but not subcutaneous adipose tissue in primary culture.
3793284.pdf
Creators: name: Metcalf, Andrew
name: Anderson, Tyler
name: Bender, Chad
name: Blakeslee, Scott
name: Brand, Wesley
name: Carlson, David
name: Cochran, William
name: Diddams, Scott
name: endl, michael
name: Fredrick, Connor
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental text
Was ist uns der gute Umweltzustand in der deutschen Nord- und Ostsee wert?
Creators: name: Osiek, Dirk
Publisher: name: Umweltbundesamt
Year: 2021
Subjects: Contingent Valuation
Ökosystemdienstleistung

description: Strong algal growth, water turbidity, overfishing, underwater noise or trash not only on the beaches are just a few examples that the North Sea and Baltic Sea are confronted with. The latest status assessment of the German North Sea and Baltic Sea waters from 2018 shows that a good status of marine waters is still a long way off. From a human well-being perspective, a marine environment in poor condition reduces the value that people place on the North Sea and Baltic Sea and the benefits, e.g., for climate protection and food. In this project, we estimate the benefits for the German population that would arise if a "Good Environmental Status" were achieved in German marine waters. For this purpose, we derive the willingness to pay of the German population for this good status in the German marine environment using the Contingent Valuation Method. Quelle: www.umweltbundesamt.de
Orbicular diorite of Fisher Lake, California: Reverse zoning and oscillatory precipitation mechanisms.
Creators: name: Durant, Dolores G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Geology.

description: Magmatic orbicules from Fisher Lake CA range up to 20 cm in diameter. They contain a central core surrounded by shells that number from one to over forty and alternate in composition from predominantly felsic to predominantly mafic. Comb layering has the same type of patterning but is found as long, linear, ribbon-like, strips ranging up to 10 m wide and dozens of metres long. Detailed petrology and extensive chemical analyses using the microprobe have been done on the orbicules, comb layering and host rocks of the Fisher Lake orbicular diorite. Within the orbicules has been found crystals of gradually, reverse-zoned, branching/budding, orthopyroxene and feather plagioclase in a radiating growth pattern extending away from the core. Shells containing these crystal shapes alternate with shells containing anhedral crystals of plagioclase, orthopyroxene, Fe-Ti oxides, amphibole and minor biotite. The comb layering consists of layers of elongated, budding, oscillatory zoned hornblende that alternate with anhedral plagioclase, pyroxene and hornblende. The comb textures within both the orbicules and the comb layering are postulated to have formed as a result of the interaction between two magmas of slightly differing chemical compositions. The comb layering formed at the boundary between a partially solidified, very warm, magma mush and a completely molten magma. The orbicules formed in the molten magma where incorporated xenoliths from the partially solidified magma acted as centres of nucleation. The comb texture crystal morphology indicates that the crystals grew under far-from-equilibrium conditions while the crystal chemistry indicates constant temperature conditions. Phase diagrams and Gibbs free energy diagrams show that reverse zoning can be achieved under these two conditions. Mathematical modelling based on the Volterra-Lotka equations produces the oscillatory precipitation of anhedral, hornblende-rich shells alternating with anhedral, Fe-Ti oxide-rich shells. Modification of the Volterra-Lotka equations by adding two non-linear terms, generates a curve similar to that of the modal percentage of orthopyroxene across an entire orbicule, i.e. an oscillating line that gradually decreases in amplitude (comparable to a damped pendulum). Orbicules and comb layering are not the result of large-scale, oscillating, magmatic conditions but are formed as a newly emplaced magma attains a new equilibrium. Therefore the comb textures are a self-organizational phenomena occurring during a far-from-equilibrium stage of crystallization in a suddenly, small-undercooled magma before the onset of widespread, near-to-equilibrium precipitation.
Genetic characterization of therapeutic resistance in cutaneous melanoma
Creators: name: Schillo, Jacob L.
Publisher: name: University of Iowa
Year: 2022
Subjects: public abstract

description: Cutaneous melanomas harbor frequent BRAF mutations that lead to hyperactivity within the MAPK pathway. Mutations that confer the BRAFV600 oncoprotein allow for BRAF to act as a monomer independent of upstream RAS activation. Combination treatments with selective BRAF/MEK inhibitors (BRAFi/MEKi) have significantly extended progression free survival to nearly 15 months. Although most patients will initially respond to treatment, therapeutic resistance occurs that most commonly reactivates the MAPK pathway through a variety of mechanisms.
description: High heterogeneity within melanoma is evident as a single biopsy can yield multiple mechanisms of resistance, yet some patients present without a known mechanism of resistance. To comprehensively analyze therapeutic resistance in melanoma, we utilized the Sleeping Beauty mutagenesis system to conduct forward genetic screens in cells sensitive to BRAFi and/or MEKi. Analysis of resistant populations revealed candidate drivers of resistance that activate an alternative RAC1 pathway. This pathway activation could be diminished by the combination treatment of BRAFi and a SRC/ABL kinase inhibitor. This novel therapy may be a successful alternative treatment for melanomas that activate this adaptive response to BRAFi/MEKi therapies.
description: In a more complex mouse model of melanoma, we identified novel drivers of BRAFi resistance specific to the in vivo environment. We created a novel single cell workflow that reveals the heterogeneity within our tumor cohorts and allows for the identification of complex genetic interactions within our screens. Through this approach we identified that the E3 ubiquitin ligase NEDD4L and non-truncated forms of BRAF cooperate to drive resistance to BRAFi in vivo, a novel function for NEDD4L.
description: Tumors are not routinely biopsied once therapeutic resistance develops, yet commonalities exist across resistant samples. Melanomas are known to contain higher levels of reactive oxygen species as a byproduct of melanogenesis and drug resistance. To exploit this vulnerability, we treated melanomas with high-dose ascorbate to overwhelm the cells’ ability to manage ROS, thereby driving apoptosis. In both BRAFi sensitive or resistant models of melanoma, several extreme responders to BRAFi + ascorbate treatment mice outperformed BRAFi cohorts. Ultimately, this work establishes the rationale for continued exploration of ascorbate and the potential for ascorbate treatments in patients with melanoma.
description: Overall, the field of melanoma has failed to advance therapies that increase patient survival outside of BRAF and MEK inhibitors. This work establishes alternative targets, pathways of activation, and alternative treatments for patients with melanoma.
Sustained Increase of 25-Hydroxyvitamin D Levels in Healthy Young Women during Wintertime after Three Suberythemal UV Irradiations—The MUVY Pilot Study
Creators: name: Biersack, Maria Gudrun
name: Hajdukiewicz, Malgorzata
name: Uebelhack, Ralf
name: Franke, Leonora
name: Piazena, Helmut
name: Klaus, Pascal
name: Hoehne-Zimmer, Vera
name: Braun, Tanja
name: Buttgereit, Frank
name: Burmester, Gerd-Ruediger
name: Detert, Jacqueline
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives Vitamin D (VitD) deficiency is a health problem prevalent not only in the elderly but also in young adults. The primary objective of our observational pilot study “MUVY” (Mood, UVR, Vitamin D in Young women) was to test both the short-term and long-term effects of a series of three suberythemal UV radiation (UVR) exposures on the VitD status and well-being of young healthy women during winter in a repeat measure design. Methods 20 healthy young women (Fitzpatrick skin types I–III, aged 21–25 years) received three full body broad band UVR exposures with an escalating erythemally weighted dose schedule during one week in winter, and completed self-report questionnaires monitoring symptoms of depression (Beck Depression Inventory, BDI) and affective state/well-being (Profile of Mood States, POMS) at baseline and three days after the last UVR exposure. 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) were measured in serum at baseline, and at study days 8, 36 and 50. Results Mean baseline 25(OH)D level was 54.3 nmol/L (standard deviation (s.d.) = 24.1), with seven women having VitD deficient status. Relevant symptoms of depression, as indicated by low BDI total scores (0–8), were absent. After the three UVR exposures the increment of 25(OH)D was an average of 13.9 nmol/L (95% confidence interval (CI) = 9.4–18.4) and 26.2 pmol/L (95%CI = 7.2–45.1) for 1,25(OH)2D. Δ25(OH)D, and corresponding baseline levels were significantly and inversely associated (rho = -0.493, p = 0.027). Only 25(OH)D remained significantly increased above baseline for at least six weeks after the last UVR exposure. A strong inverse correlation of the POMS subscale “Vigor/Activity” and the increment in 1,25(OH)2D was found (rho = -0.739, p<0.001) at day 8. Conclusions Three suberythemal whole body UVR exposures during one week are a simple and suitable method for improving 25(OH)D levels during winter, for at least six weeks, and especially in young women with VitD deficient status. Trial Registration German Clinical Trials Register (Deutsches Register Kinischer Studien) DRKS00009274
What do the .XXX disputes tell us about Internet governance? ICANN’s legitimacy deficit in context
Creators: name: Lindsay, David
Publisher: name: Swinburne
Year: 2024

description: The Internet Corporation for Assigned Names and Numbers (ICANN) is a private, not-for-profit corporation incorporated under Californian law, which is responsible for managing and developing policies for the Domain Name System (DNS), a valuable global resource. As a non-state actor, with no clear source of authority under international law, ICANN has weak claims to formal legitimacy. To bolster its normative claims to legitimacy, ICANN has introduced internal structural and procedural safeguards to ensure transparency and accountability. Its structural safeguards, based on the multi-stakeholder model, entrench roles for governments, the private sector and civil society in the policy-making process. The privileged position given to government representatives in the Governmental Advisory Committee (GAC) enhances ICANN's weak claims to legitimacy, but risks undermining procedural safeguards through undue government influence. ICANN's procedural safeguards include requirements to act openly, transparently and fairly, and incorporate an independent review mechanism. This article evaluates ICANN's claims to legitimacy by means of a case study of the process for approving the controversial .XXX gTLD. An analysis of the disputes involving .XXX reveals flaws with ICANN's structural and procedural safeguards. As this article argues, however, ICANN's weak claims to legitimacy do not necessarily mean that DNS management and policy-making should be transferred to an international treaty-based organisation. In a time when concepts of legitimacy are in transition, with traditional concepts being challenged and new concepts yet to fully emerge, all international organisations must continually negotiate their legitimacy with networks of stakeholders. While ICANN's weak legitimacy will result in ongoing challenges to its key management and policy-making roles, attention should focus on improving its mechanisms for accountability and transparency, as well as the organisation's competence and effectiveness.
3759064.pdf
Creators: name: Bouchet, Dorian
name: Scholler, Jules
name: Blanquer, Guillaume
name: Wilde, Yannick De
name: Izeddin, Ignacio
name: KRACHMALNICOFF, Valentina
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplemental document containing detail about the experimental setup and sample preparation, data analysis, numerical simulation and Cramer-Rao analysis for position and decay rate estimation
Subcarrier multiplexing for fiber-based video distribution: A performance study.
Creators: name: Neusy, Philippe Claude.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Electronics and Electrical.

description: Subcarrier transmission of muti-channel video signals over optical fibers may find widespread application in video distribution systems. This thesis details a comparative study that has been conducted for subcarrier multiplexing systems using various video signal modulation formats. In particular, we have investigated: AM-VSB (NTSC), high-index FM, 4-level QAM, and HDTV (Zenith). For each modulation scheme, a minimum CNR must be achieved to meet the required SNR. For analog fiber optic systems, system degradation results from laser intrinsic nonlinearities and clipping at threshold, and from noise sources (laser RIN (relative intensity noise), signal shot noise and preamplifier thermal noise at the receiver). We have also considered the possibility of using laser optical amplifiers to increase the system margin. Again, device nonlinearities must be considered, as well as further degradation from signal-spontaneous beat noise. A communication system simulator software package BOSS (Block Oriented Systems Simulator) was used to develop a laser model based on the classic laser rate equations to predict nonlinear distortion. Adding Langevin noise terms to the rate equations, BOSS was also used to obtain the RIN spectrum. A similar model was developed for the optical amplifier based on the rate equation and wave equation of the optical amplifier. Results of the comparative study are given.
The Association between Maternal Stress and Childhood Eczema: A Systematic Review
Creators: name: Chan, Carmen W. H.
name: Law, Bernard M. H.
name: Liu, Yun-Hong
name: Ambrocio, Alexandra R. B.
name: Au, Natasha
name: Jiang, Melody
name: Chow, Ka Ming
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Eczema is a chronic atopic disease that is highly prevalent among children worldwide. Identification of factors that may contribute to childhood eczema is needed in order to develop strategies in its prevention. Over the past decade, accumulating evidence has suggested a potential correlation between the experience of stress by mothers and the risk of eczema development in their child. The present review attempts to provide an overview of the studies that contribute data on this correlation. The literature search was conducted using five databases, resulting in the inclusion of eleven studies in the review. The findings of these studies were summarized narratively. Further, an appraisal of the reporting quality of the included studies was conducted using a twelve-item checklist adapted from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. Overall, the included studies showed that a positive correlation exists between the experience of stress among mothers and eczema risk of their child. The findings highlight the importance of the implementation of stress reduction programs for pregnant women and those in their postpartum period within communities in order to enable these individuals to relieve stress effectively.
Investigation of heavy quark and multiple interactions at HERA
Creators: name: Marti Magro, Lluis
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2005
Subjects: thesis
electron p: colliding beams
electron p: inclusive reaction
heavy quark
quark: photoproduction
quark: particle identification
multiple scattering
photon: resolved
parton: showers
D*(2010): photoproduction
jet: associated production
differential cross section: transverse momentum
rapidity dependence
multiplicity: spectrum
numerical calculations: Monte Carlo
H1
DESY HERA Stor

description: Universität Hamburg, Diplomarbeit, 2005; 101 pp., (2005). doi:10.3204/DESY-THESIS-2005-030
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Proteolipid protein-induced mouse model of multiple sclerosis requires B cell-mediated antigen presentation
Creators: name: Wilhelm, Connor
Publisher: name: University of Iowa
Year: 2023
Subjects: public abstract

description: The pathogenic role B cells play in multiple sclerosis (MS) is underscored by the success of B cell depletion therapies. Yet, it remains unclear how B cells contribute to disease, although it is increasingly accepted that mechanisms beyond antibody production are involved. Better understanding of pathogenic interactions between B cells and autoreactive CD4 T cells will be critical for novel therapeutics. To focus investigation on B cell:CD4 T cell interactions in vivo and in vitro, we previously developed a B cell-dependent, antibody-independent experimental autoimmune encephalomyelitis (EAE) mouse model driven by the extracellular sequences of myelin proteolipid protein (PLPECD). In this study, we demonstrate that B cell depletion significantly inhibited PLPECD-induced EAE disease, blunted PLPECD-elicited delayed-type hypersensitivity reactions in vivo, and reduced CD4 T cell activation, proliferation, and proinflammatory cytokine production. Further, PLPECD-reactive CD4 T cells sourced from B cell-depleted donor mice failed to transfer EAE to naïve recipients. Importantly, we identified B cell-mediated antigen presentation as the critical mechanism explaining B cell-dependence in PLPECD-induced EAE, where bone marrow chimeric mice harboring a B cell-restricted MHC class II deficiency failed to develop EAE. B cells were ultimately observed to restimulate PLP178-191-reactive CD4 T cell proliferation more efficiently than dendritic cells when provided PLPECD peptide in head to head cultures. We therefore conclude that PLPECD-induced EAE features a required pathogenic B cell-mediated antigen presentation function, providing for investigable B cell:CD4 T cell interactions in the context of autoimmune demyelinating disease.
Video game training and the reward system
Creators: name: Lorenz, Robert C.
name: Gleich, Tobias
name: Gallinat, Jürgen
name: Kühn, Simone
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie

description: Video games contain elaborate reinforcement and reward schedules that have the potential to maximize motivation. Neuroimaging studies suggest that video games might have an influence on the reward system. However, it is not clear whether reward-related properties represent a precondition, which biases an individual toward playing video games, or if these changes are the result of playing video games. Therefore, we conducted a longitudinal study to explore reward-related functional predictors in relation to video gaming experience as well as functional changes in the brain in response to video game training. Fifty healthy participants were randomly assigned to a video game training (TG) or control group (CG). Before and after training/control period, functional magnetic resonance imaging (fMRI) was conducted using a non-video game related reward task. At pretest, both groups showed strongest activation in ventral striatum (VS) during reward anticipation. At posttest, the TG showed very similar VS activity compared to pretest. In the CG, the VS activity was significantly attenuated. This longitudinal study revealed that video game training may preserve reward responsiveness in the VS in a retest situation over time. We suggest that video games are able to keep striatal responses to reward flexible, a mechanism which might be of critical value for applications such as therapeutic cognitive training.
The IL6Myc mouse Is an immunocompetent model of aggressive human Multiple Myeloma which recapitulates key disease characteristics
Creators: name: Pisano, Michael
Publisher: name: University of Iowa
Year: 2023
Subjects: Hematological malignancies
Mouse models
Multiple myeloma
Plasma cell malignancies
Transgenic mice
public abstract

description: Multiple Myeloma (MM) remains the second most common blood cancer in the United States and while advancements in anti-MM immunotherapies have made the disease manageable, the majority of patients still relapse. For this reason, there is a critical need for immunocompetent preclinical models to examine disease etiology and for the development of novel treatments. To this end the Janz laboratory developed the IL6Myc mouse, which develops MM with 100% penetrance in 45-175 days, and recapitulates key disease characteristics such as measurable M-spike and myeloma-like bone disease. To determine if the mice molecularly resemble human MM, we undertook comprehensive genomic analysis. We found that IL6Myc tumors resemble aggressive MM by RNA and protein expression. Additionally, IL6Myc tumors accumulated fusions and missense mutations in genes that overlap significantly with human myeloma, indicating that the mouse is a good model for studying disease etiology. All of this indicates that the IL6Myc model is useful for studying development of aggressive MM and for developing new treatments against some aggressive forms of the disease. Additionally, we derived 5 independent cell lines from IL6Myc tumors that express cell-surface markers typical of MM and readily engraft into mice, home to the bone marrow, and induce osteolytic disease. In addition to examining IL6Myc mice on a molecular level work was done to examine the tumor microenvironment of these mice via bone imaging and measurement of proteins which contribute to osteolytic bone disease, and via flow cytometry of immune cells in the IL6Myc tumor microenvironment. We found that IL6Myc mice develop osteolytic myeloma-like bone disease and develop a fully anti-MM immune response with trends in late-stage (26wks) mice that suggest immune exhaustion.
Le problème de la motivation dans le développement de la conscience morale chez Karl-Otto Apel.
Creators: name: Artaud, Janick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Philosophy.

description: L'objectif de ce mémoire est de reconstruire l'essentiel de l'éthique déontologique de Karl-Otto Apel à la lumière de la question de la motivation. C'est à partir de la théorie du développement de la conscience morale du psychologue Lawrence Kohlberg que nous abordons cette recherche. Kohlberg représente en effet une véritable référence pour l'éthique du discours et l'éthique de la responsabilité développées par Apel, et c'est à partir de son ontogénèse que ce dernier entreprend de reconstruire, à son tour, une phylogénèse qui retrace l'évolution morale des civilisations. De plus, en prenant conscience des limites de la raison quant à la possibilité de répondre à la question «pourquoi être moral?» et en développant un stade 7 métaphysico-religieux, Kohlberg a suscité chez Karl-Otto Apel une réflexion qui l'a conduit à élaborer, à son tour, un stade 7 qui entend répondre à la même question mais d'une manière strictement rationnelle. L'analyse comparative de ces deux stades nous conduira à proposer une interprétation originale du 7 e stade de Karl-Otto Apel et par le fait même de vérifier la pertinence de la réponse qu'il apporte à cette question de la motivation.
Search for point sources of high-energy neutrinos with the AMANDA detector
Creators: name: Lang, Rafael Florian
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2005
Subjects: thesis
neutrino: cosmic radiation
neutrino: particle source
astrophysics
neutrino: particle identification
angular correlation
correlation: time
flux: time dependence
programming: Monte Carlo
Cherenkov counter: water
water: solids
photomultiplier
efficiency
experimental results
AMANDA
bibliography

description: University of Ulm, Diplomarbeit, 2005; 104 pp., (2005). doi:10.3204/DESY-THESIS-2005-031
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Association between chemerin, omentin-1 and risk of heart failure in the population-based EPIC-Potsdam study
Creators: name: Menzel, Juliane
name: Di Giuseppe, Romina
name: Biemann, Ronald
name: Wittenbecher, Clemens
name: Aleksandrova, Krasimira
name: Eichelmann, Fabian
name: Fritsche, Andreas
name: Schulze, Matthias B.
name: Boeing, Heiner
name: Isermann, Berend
name: Weikert, Cornelia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Biomarkers
subject: Heart failure
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 27548) including a randomly drawn subsample and all incident HF cases during a mean follow-up of 8.2 ± 1.5 years. A total of 212 incident HF cases and 2168 individuals free of HF cases were included in the study. After multivariable adjustment for established cardiovascular risk factors chemerin was strongly associated with risk of HF (HR per doubling chemerin: 4.91; 95%-CI: 2.57–9.39; p
3759064.pdf
Creators: name: Bouchet, Dorian
name: Scholler, Jules
name: Blanquer, Guillaume
name: Wilde, Yannick De
name: Izeddin, Ignacio
name: KRACHMALNICOFF, Valentina
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplemental document containing detail about the experimental setup and sample preparation, data analysis, numerical simulation and Cramer-Rao analysis for position and decay rate estimation
Transverse momentum of gluons in ep scattering at HERA
Creators: name: Cholewa, Axel
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2005
Subjects: thesis
electron p: deep inelastic scattering
hadron: photoproduction
jet: photoproduction
differential cross section: factorization
transverse momentum: dependence
x-dependence
gluon: transverse momentum
gluon: momentum spectrum
phase space
heavy quark
programming: Monte Carlo
numerical calculations: Monte Carlo
interpretation of experiments: DESY HERA Stor

description: Universität Hannover, Diplomarbeit, 2005; 112 pp., (2005). doi:10.3204/DESY-THESIS-2005-033
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Assessing the Implementation of Equitable Grading Practices Through an Analysis of High School Students’ Perception of their Academic Motivation
Creators: name: Colbert, Justin
Publisher: name: University of Iowa
Year: 2023
Subjects: Equitable grading practices
grading practices
academic motivation
equity
grading
grading policy
student motivation

description: Grades matter because they are the most widely used and universally accepted metric for measuring student learning and determining academic achievement. For more than a century, many American schools have used students grades to determine academic awards and recognition, assign students into advanced or remedial classes, decide which students will receive talented and gifted services, determine which students are eligible to compete in extracurricular activities, and more. Therefore, if a great deal of value is placed on grades, what steps can be taken to determine if the grades being assigned in schools, especially high schools, are fair, accurate, and motivating?
description: The focus of this study was around the question of “What can be learned from the implementation of equitable grading practices and the relationship it has with students’ perception of their academic motivation?” Following the two-and-a-half-year implementation of a building-wide grading policy that prioritized equitable grading practices, a survey was administered to all high school students who attended the school where this study took place. The survey was designed to assess if students believed their grades were equitable, and to determine which grading practices were more academically motivating for high school students, traditional or equitable grading practices.
description: The results of the survey indicated that overall, most students who participated in the survey believe their grades are equitable. Some discrepancies between the whole population and some of the subgroups were discovered, but all the subgroups also agreed that their grades were accurate, fair, and motivating. They survey also indicated that overall, students identified equitable grading practices as being more motivating than their traditional grading practice counterpart. However, there were two exceptions where the traditional grading practice was identified as being more motivating than their equitable grading counterparts.
Application of GAC adsorption in pulp and paper mill effluent treatment.
Creators: name: Zheng, Jing.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Engineering, Civil.

description: Aerated stabilization basins (ASB) and activated sludge treatment (AST) are the most popular unit processes in the treatment of Pulp and paper mill effluents. However, these traditional biological processes can only provide partially satisfactory treatment because many components in pulp and paper mill wastes are persistent under the conditions of these processes. This study evaluated the application of granular activated carbon (GAC) adsorption using fixed-bed columns in the post-treatment of the whole-plant effluent of a Kraft and fine paper manufacturer. A mathematical model, the branched pore or dual rate model, was used to simulate the GAC column adsorption process. The computer program PRECOS was used to solve the model. The wastewater was first treated using a traditional AST system and then filtered and passed through a small-scale GAC column to obtain data for estimating mass transfer coefficients of the model. CalgonRTM F400 GAC was used. Isotherm studies were carried out for column influents to determine the adsorption capacity of the GAC. A simplified form of the dual rate model was used to predict the column performance in terms of treatment efficiency, consumption of carbon, and organic removal. The mass transfer coefficients of the model were determined based on microcolumn experimental data. The performance of AST system followed by GAC column adsorption process was compared to that of a PACT(TM) system in the treatment of a similar wastewater. It was found that for an overall COD removal of 80%, the carbon usage rate of the PACT(TM) system was 30% lower than that of the GAC column system. The lower performance of the GAC column system was attributed to a possible low efficiency in terms of carbon usage in the microcolumn experiment. A direct comparison between the two systems based on experiments is also needed.