A Compendium to S-Phase Entry and Exit
Creators: name: Burgess, Andrew
name: Vuong, Jenny
name: Marzec, Kamila A
name: Lichtenberg, Ulrik Nicolai de
name: O'Donoghue, Seán I
name: Jensen, Lars Juhl
Publisher: name: Zenodo
Year: 2019
Subjects: Cell Cycle
DNA Replication
S-phase
Checkpoint
Retinoblastoma Protein
Cyclin Dependent Kinase
Restriction Point
G1 phase
Phosphorylation
Pre-Replication Complex
origin recognition complex
CMG Complex
DNA polymerase
Centrosome Duplication

description: S-phase entry and exit is regulated by many protein complexes that assemble ‘just-in-time’, orchestrated by thousands of distinct events - including external signals, subcellular translocation, phosphorylation, association, transcription, and degradation (Jensen et al., 2006). To help understand how these complex processes regulate S-phase, we selected 83 events believed to play key roles, and used them to create a tailored visualization (Burgess et al., 2019) based on the ‘Minardo’ layout, in which time flows around a schematic ‘circtanglar’ cell (Ma et al., 2013). In an interactive version of this visualization – available at https://minardo.org/s-phase – clicking on each event opens a popup with a text summary, and with links to supporting literature in PubMed, protein sequence information in UniProt (The UniProt Consortium, 2019), and related 3D structures in Aquaria (O’Donoghue et al., 2015). Below, in this publication, we have compiled this information from the 83 popups in the online interactive visualization, thereby making this information more easily accessible, and to also better acknowledging the contributions of the &gt;280 scientific publications used in assembling the visualization. We designed the S-phase visualization to complement our earlier visualization on the phosphoregulation of mitosis (Burgess et al., 2017; https://minardo.org/mitosis). Both can be displayed together, giving a comprehensive overview of the events regulating the mitotic cell cycle.
description: This compendium accompanies the publication in Cell 173, October 17, 2019. DOI: http://dx.doi.org/10.1016/j.cell.2019.09.031 and the interactive website which can be found here: https://minardo.org/s-phase In addition, the complementary mitosis snapshot can be found here: https://minardo.org/mitosis and the associated compendium here: https://doi.org/10.5281/zenodo.3380621 A.B. is supported by NBCF IIRS grant (#IIRS-18-103). J.V. and S.I.O. were supported by CSIRO's OCE Science Leader program. L.J.J. is supported by the Novo Nordisk Founda- tion (NNF14CC0001). The authors thank Benedetta Frida Baldi for creative input.
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