title: ÐÐ¾Ð·Ð¸Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð¿Ð»Ð°Ð½Ð¾Ð² ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸ÑÑÑÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ð¾Ð² Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¼ Ð¼Ð¾Ð·Ð³Ðµ Ð½Ð° Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ°Ñ Cyber Knife Ð¸ TrueBeam STx
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Dosimetric comparison of plans for radiosurgical treatment of brain metastases using Cyber Knife and TrueBeam STx devices
Creators: name: ÐÑÑÐµÐ¼ÑÐµÐ²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÑÐµÑÐµÐ¾ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐ°Ð´Ð¸Ð¾Ñ Ð¸ÑÑÑÐ³Ð¸Ñ
Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ñ Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¹ Ð¼Ð¾Ð·Ð³
Cyber Knife
TrueBeam STx
HyperArc
stereotactic radiosurgery
brain metastases

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¾ÑÐµÐ½ÐºÐµ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿Ð»Ð°Ð½Ð¾Ð² Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¸ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ð´Ð¾Ð·Ð¸Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð´Ð¾Ð·Ð¾Ð²ÑÑ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ð¹ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ð¾Ð² Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¹ Ð¼Ð¾Ð·Ð³ Ð½Ð° ÑÐ°Ð´Ð¸Ð¾ÑÐ¸ÑÑÑÐ³Ð¸ÑÐµÑÐºÐ¸Ñ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ°Ñ Cyber Knife Ð¸ TrueBeam STx, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¾ÑÐµÐ½ÐºÐµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ ÐºÐ°ÑÐµÑÑÐ²Ð° Ð¿Ð»Ð°Ð½Ð¾Ð² Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¸ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Ð½Ð° Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð´Ð¾Ð·Ð¸Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð°, ÑÐ°Ð·Ð¼ÐµÑÐ° Ð¸ Ð»Ð¾ÐºÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ð¾Ð². Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¾ÑÐµÐ½Ð¸Ð²Ð°Ð»Ð¸ÑÑ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð´Ð¾Ð·Ð¸Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº â Ð³Ð¾Ð¼Ð¾Ð³ÐµÐ½Ð½Ð¾ÑÑÑ (HI), Ð¿Ð¾ÐºÑÑÑÐ¸Ðµ (Coverage/Ð¡Ð), Ð¸Ð½Ð´ÐµÐºÑÑ ÐºÐ¾Ð½ÑÐ¾ÑÐ¼Ð½Ð¾ÑÑÐ¸ (nCI, CI, mCI,Â  PCI), Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ½ÑÐµ Ð¸Ð½Ð´ÐµÐºÑÑ (GI50, GI25), Ð½Ð°Ð³ÑÑÐ·ÐºÐ° Ð½Ð° Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½ÑÐµ ÑÐºÐ°Ð½Ð¸ (V12, V12-PTV, V10, V10-PTV, V2, V2-PTV, Dmean(brain), Dmean(brain-PTV)), Ð½Ð°Ð³ÑÑÐ·ÐºÐ° Ð½Ð° ÐºÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÑÑÑÐºÑÑÑÑ (Brainstem, Eyes, optic nerves, Chiasm), Dmin, Dmax Ð¸ Dmean, Ð´Ð¾Ð·Ñ ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿ÑÐ¸ÑÐ¾Ð´ÑÑÑÑ Ð½Ð° 5 % Ð¸ Ð½Ð° 95 % Ð¾Ð±ÑÑÐ¼Ð° Ð¼Ð¸ÑÐµÐ½Ð¸ (D5%, D95%) â ÑÐ°ÑÑÑÐ¸ÑÑÐ²Ð°Ð»Ð¸ÑÑ Ð¸Ð· Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð³Ð¸ÑÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Ð´Ð¾Ð·Ð°-Ð¾Ð±ÑÑÐ¼ (ÐÐÐ/DVH). ÐÐ»Ñ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð´Ð°Ð½Ð½ÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ SPSS StatisticÐ° Ð²ÐµÑÑÐ¸Ð¸ 22 Ð¸ Excel. ÐÑÐ¾Ð³Ð¾Ð²ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð² Ð²Ð¸Ð´Ðµ ÑÑÐµÐ´Ð½Ð¸Ñ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ð¹, ÑÑÐ°Ð½Ð´Ð°ÑÑÐ½Ð¾Ð³Ð¾ Ð¾ÑÐºÐ»Ð¾Ð½ÐµÐ½Ð¸Ñ Ð¸ ÑÑÐ¾Ð²Ð½Ñ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ñ. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ: Ð¿ÑÐ¸ Ð¾Ð±ÑÐµÐ¼ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¸ Ð¿Ð»Ð°Ð½Ð¾Ð² Ð»ÐµÑÐµÐ½Ð¸Ñ Ð¡Ð Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ Ð»ÑÑÑÐ¸Ðµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ, ÑÐµÐ¼ Ð¢Ð. ÐÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ Ð¾Ð´Ð¸Ð½Ð¾ÑÐ½ÑÑ Ð¾ÑÐ°Ð³Ð¾Ð² ÑÐ¾ÑÐ¾ÑÐ¾ ÑÐ¿ÑÐ°Ð²Ð»ÑÑÑÑÑ Ñ Ð·Ð°Ð´Ð°ÑÐµÐ¹ Ð¸ Ð¢Ð, Ð¸ Ð¡Ð. ÐÑÐ¸ Ð¼Ð½Ð¾Ð¶ÐµÑÑÐ²ÐµÐ½Ð½ÑÑ Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ð°Ñ Ð»ÑÑÑÐ¸Ðµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ Ð¡Ð. ÐÐ°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð¾Ñ Ð¾Ð±ÑÑÐ¼Ð° Ð¿ÑÐ¾ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ¾Ð»ÑÐºÐ¾ Ð´Ð»Ñ Ð¢Ð Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ Ð¾ÑÐ°Ð³Ð¾Ð² Ð±Ð¾Ð»ÑÑÐ¸Ñ ÑÐ°Ð·Ð¼ÐµÑÐ¾Ð² [1.49 â 5.93] ÑÐ¼3. ÐÐ¾ÐºÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð½Ðµ Ð²Ð»Ð¸ÑÐµÑ Ð½Ð° Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ Ð´Ð¾Ð·Ð¾Ð²ÑÑ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ð¹. ÐÑÐ¸ ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ð¸ Ð½ÐµÐ¿Ð¾ÑÑÐµÐ´ÑÑÐ²ÐµÐ½Ð½Ð¾ Ð² Ð±Ð»Ð¸Ð·Ð¸ ÐºÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÑÑÐºÑÑÑÑ Ð»ÑÑÑÐµÐµ Ð´Ð¾Ð·Ð¾Ð²Ð¾Ðµ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð¸ Ð¼ÐµÐ½ÑÑÑÑ Ð¾Ð±ÑÑÑ Ð½Ð°Ð³ÑÑÐ·ÐºÑ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð» Ð¡Ð. ÐÑÐ²Ð¾Ð´: ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÑÑ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð½ÑÐ¶Ð½Ð¾ Ð½Ðµ ÐºÐ¾Ð½ÐºÑÐµÑÐ½Ð¾ Ð¾Ñ Ð¾Ð´Ð½Ð¾Ð³Ð¾ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ°, Ð° ÑÑÐ¸ÑÑÐ²Ð°ÑÑ ÑÐ¾Ð²Ð¾ÐºÑÐ¿Ð½Ð¾ÑÑÑ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² (Ð¼Ð½Ð¾Ð³Ð¾Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ°Ñ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ) - Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð»ÐµÑÐµÐ±Ð½Ð¾Ð³Ð¾ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ°, ÑÐ°Ð·Ð¼ÐµÑÐ°, Ð»Ð¾ÐºÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¸ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ð¾Ð².
description: This work is devoted to assessing the quality of treatment plans and comparing the dosimetric parameters of dose distributions of irradiation of brain metastases on the Cyber Knife and TrueBeam STx radiosurgical devices, as well as assessing the dependence of the quality of treatment plans and the impact on the values of dosimetric parameters of the number, size and localization of metastases. During the study, the values of dosimetric characteristics were evaluated - homogeneity (HI), coverage (Coverage / CO), conformity indices (nCI, CI, mCI, PCI), gradient indices (GI50, GI25), doses to normal brain tissues (V12, V12-PTV , V10, V10-PTV, V2, V2-PTV, Dmean(brain), Dmean(brain-PTV)), doses to critical structures (Brainstem, Eyes, optic nerves, Chiasm), Dmin, Dmax and Dmean, doses corresponding to 5% and 95% of the target volume (D5%, D95%) were calculated from the obtained dose-volume histograms (DVH). SPSS Statistica version 22 and Excel were used for data processing and analysis. The final data are presented as means, standard deviation and statistical significance p. Results: General comparison of treatment plans revealed that Cyber Knife showed better results than TrueBeam STx. In the treatment of single metastasis, both radiation devices demonstrated similar results. With multiple metastases, CK showed better results. The volume dependence appeared only for TB in the treatment of large lesions [1.49 â 5.93] cm3. Localization did not affect significantly the parameters of dose distributions. When located directly in the vicinity of the critical structure, better dose distribution and lower total radiation load were obtained with CK. Conclusion: It is necessary to consider the dependence not specifically on one parameter, but take into account a combination of factors (multi-parameter dependence) - features of the medical device, size, localization and number of brain metastases, - in order to provide radiosurgical treatment with high efficacy and safety.