cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Die Auswirkung von Einzelbindungs-Konformationsänderungen auf die Polyprolin II Sekundärstruktur
Creators: name: Wawra, Stephan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2007
Subjects: subject: Elektronische Publikation
subject: Hochschulschrift
subject: Online-Publikation
subject: Zsfassung in engl. Sprache
subject: 547.7
subject: 572.633

description: Der Polyprolin II-Helix (PP II) wurde, im Gegensatz zu den klassischen Sekundärstrukturen wie α-Helix, β-Faltblatt oder Schleifenstrukturen, bisher wenig Beachtung geschenkt. Dieses Phänomen ist darauf zurückzuführen, dass dieses Sekundärstrukturelement oft als ungefaltet oder "random" Zustand angesehen wurde. In vivo dagegen sind PP II-helikale Polypeptide wichtige Strukturen für die Übertragung zellulärer Signale. Ziel dieser Arbeit war es, erstmalig ein einheitliches Modell zu entwerfen, dass den Einfluss von Einzelbindungs-Konformationsänderungen auf die Polyprolin-(PP) Sekundärstrukturen, unter Einbezug aller bisherigen Literaturdaten, beschreiben kann. Zu diesem Zweck wurden Polyprolinpeptide untersucht, in denen ortsspezifisch das Carbonylsauerstoffatom einer Peptidbindung gegen ein Schwefelatom ausgetauscht war. Dieses erlaubte die Detektion einzelner Peptidbindung innerhalb der untersuchten Peptide, und ermöglichte eine vergleichende Analyse von Photo- und Lösungsmittelinduzierten cis/ trans-Gleichgewichtsverschiebung auf die PP-Sekundärstrukturen. Die Untersuchungen wurden anhand unstrukturierter Dipeptide als auch mit 13 gliedrigen Polyprolin-Peptiden durchgeführt. Diese Studien zeigten, dass PP I- und PP II-Helices nicht an allen Positionen die gleichen Freiheitsgrade besitzen und nur "Idealfälle" darstellen, da verschiedene semistabile Intermediatstrukturen existieren.
description: In contrast to the classical secondary structures, α-helix, β-sheet and turn structures, less attention was paid at the poly-proline (PP) II-helix in the last decade. This phenomenon might be caused by the fact that this structure was often falsely assigned as random or unfolded. However, in vivo PP II structures play an important role for many cell signalling processes. The main goal of this work was to establish a model, including the present literature, which described the influence of single conformational switches on the PP secondary structures. For this purpose we synthesized peptides where a single carbonyl oxygen atom of a 13mer polyproline peptides was replaced by sulphur. The resulting thioxopeptides allowed the detection of structural changes of a single peptide bond within the polyproline-peptides and were used for comparative analyses of photo- and solvent induced cis/ trans isomerisation processes of the PP secondary structures. The kinetic and thermodynamic properties of the different thioxo-polyproline peptides and reference thioxo dipeptides showed that PP I- and PP II-helices do not possess the same degrees of freedom at every position within such a structure. Therefore, the PP I- and PP II-helices represent only an ideal state of such structures.
title: Вопросы правоприменительной практики по делам о лишении родительских прав
Creators: name: Богданов, Н. И.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: Настоящая статья посвящена одной из наиболее важных проблем современности в области судебных споров, связанных с воспитанием детей – это лишение родительских прав. В данной статье анализируется вопрос осуществления производства по делам данной категории, а также уделено особое внимание специфике механизма его правового регулирования.
title: Foreign Policy (The Netherlands)
title: Foreign Policy (The Netherlands)
Creators: name: Abbenhuis, Maartje
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Niederlande
subject: Außenpolitik
subject: Weltkrieg [1914-1918]
subject: Netherlands--Foreign relations--1898-1948

description: The Kingdom of the Netherlands upheld a foreign policy of strict neutrality during the First World War. That policy revolved around two main precepts: upholding the requirements associated with neutrality in international law (particularly the Hague Conventions of 1899 and 1907), and careful management of the country’s relationships with the belligerents. By war’s end, the Dutch government’s ability to defend the Netherlands’ neutral rights and sovereign independence had declined significantly.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
High performance GaAs monolithic transimpedance amplifiers for multigigabit per second fiber optic links
Creators: name: Mauri, A.
name: Bastida, E.M.
name: Chiappa, P.A.
name: Donzelli, G.P.
name: Feudale, M.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1990
Subjects: ING-INF/01 Elettronica

description: A new design approach for MMIC transimpedance amplifiers is described, which allows substantial improvements as noise, gain and stability over the previously reported circuit solutions. An accordingly designed MMIC transimpedance ampli­fier we constructed and tested is described.
Additional file 2: of Presence and diagnostic value of circulating tsncRNA for ovarian tumor
Creators: name: Peng, Eric
name: Shu, Yang
name: Wu, Yuke
name: Zeng, Feier
name: Tan, Shuangyan
name: Deng, Yun
name: Deng, Yiqi
name: Chen, Haining
name: Zhu, Lei
name: Xu, Heng
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Cancer

description: Figure S1. Comparing circulating tsncRNAs content among different diagnostic and histology types. a Comparing serum tsncRNAs content among different diagnostic types. b circulating tsncRNAs content among different histology types. Figure S2. Length distribution of tsncRNA from 3â ˛, 5â ˛ and inter of tRNA among ovarian tumors and controls. (PDF 238 kb)
Non-negative global weak solutions for a degenerate parabolic system modeling thin films driven by capillarity
Creators: name: Matioc, Bogdan-Vasile
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35D30, 35K41, 35K55, 35K65, 35Q35

description: We prove global existence of nonnegative weak solutions for a strongly coupled, fourth order degenerate parabolic system governing the motion of two thin fluid layers in a porous medium when capillarity is the sole driving mechanism.
description: Final version
title: Film/Cinema (The Netherlands)
title: Film/Cinema (The Netherlands)
Creators: name: Zwaan, Klaas De
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Film
subject: Weltkrieg [1914-1918]
subject: World War, 1914-1918--Motion pictures and the war

description: Film did not undermine Dutch neutrality during the First World War, but Dutch cinema culture was an important hub for propagandistic messages from most warring parties. Although British and French film propaganda in the Netherlands could be considered far more successful than that of the Germans, their films were used and interpreted in ways that did not always match their original intentions. Dutch cinemas functioned as a site of political affiliation ''and'' contestation, allowing audiences to rethink their political identities and the relationship between war, film, and the “real”.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
A Semi-group Expansion for Pricing Barrier Options
Creators: name: Kato, Takashi
name: Takahashi, Akihiko
name: Yamada, Toshihiro
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computational Finance (q-fin.CP)
subject: Analysis of PDEs (math.AP)
subject: Probability (math.PR)
subject: FOS: Economics and business
subject: FOS: Mathematics
subject: 91G20 (Primary), 35C20 (Secondary), 35B20

description: This paper presents a new asymptotic expansion method for pricing continuously monitoring barrier options. In particular, we develops a semi-group expansion scheme for the Cauchy-Dirichlet problem in the second-order parabolic partial differential equations (PDEs) arising in barrier option pricing. As an application, we propose a concrete approximation formula under a stochastic volatility model and demonstrate its validity by some numerical experiments.
description: 29 pages
THE ECONOMIC AND PSYCHOLOGICAL ADVANTAGES OF LOCAL RECREATIONAL TOURISM IN BUKHARA
Creators: name: Madina Sayfullayeva Bukhara state university, the department of tourism and hotel management,  Bukhara, Uzbekistan  e-mail: m.s.sayfullayeva@buxdu.uz
Publisher: name: Zenodo
Year: 2025

description: Bukhara, a UNESCO World Heritage site, is renowned for its historical and cultural significance. However, the city’s potential for recreational tourism at the local level remains underexplored. This article investigates the economic and psychological benefits of developing local recreational tourism in Bukhara, emphasizing its role in diversifying the city’s tourism offerings beyond heritage attractions. Using qualitative and quantitative data, the study highlights how local recreational tourism can stimulate economic growth, reduce travel-related stress, and foster community well-being. The findings underline that sustainable investment in recreational infrastructure and activities can enhance Bukhara’s appeal for both residents and visitors.
title: Ferry, Abel
title: Ferry, Abel
Creators: name: Loez, André
Publisher: name: BSB - Bavarian State Library
Year: 2017
Subjects: subject: Ferry, Abel
subject: Ferry, Abel, 1881-1918

description: Abel Ferry was a French politician and minister as well as an infantry combatant, who used his first-hand knowledge of the war to try and shape the official war effort. He died as a result of his parliamentary inquiries at the front. His diaries and letters are important sources on the period.
description: 1914-1918-Online International Encyclopedia of the First World War
description: 1914-1918-Online International Encyclopedia of the First World War
Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells
Creators: name: Zhang, Yan
name: Wang, Qin
name: Li, Luolan
name: Le, Yi
name: Liu, Li
name: Yang, Jing
name: Li, Yongliang
name: Bao, Guochen
name: Yan, Longjia
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and tumour cells (A431, A549, MCF-7, and NCI-H1975). In particular, compound 4d 3-fluoro-N-(4-((3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methoxy)phenyl)benzamide showed higher antiproliferative activities against all tumour cells than Gefitinib (IC50 of 3.48, 2.55, 0.87 and 6.42 μM, respectively). Furthermore, compound 4d could induce apoptosis of MCF-7 cells and arrest in G2/M phase at the tested concentration. Molecular docking and ADMET studies showed that compound 4d could closely form many hydrogen bonds with EGFRwt-TK. Therefore, compound 4d is potential to develop as novel anti-cancer drug.
Screening efficiency of networks
Creators: name: Lanzi, Diego
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/07 Economia aziendale

description: In this paper, we study screening efficiency of networks as organizations in comparison with polyarchies and hierarchies. Firstly, we briefly
characterize these organizational architectures, then we rank them in the case
of infinitely many and finitely many decisional units. As we show and discuss,
networks are more efficient than polyarchies and hierarchical architectures with
good initial choice portfolios. In opposition, whether Type II errors are very
likely to occur, a hierarchy preforms better than polyarchies and networks. Finally, we illustrate how these organizations perform when a budget constraint
has to be fulfilled.
The skill content of technological change.
Some conjectures on the role of education and job-training in reducing
the timing of new technology adoption
Creators: name: Antonietti, Roberto
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2006
Subjects: SECS-P/01 Economia politica

description: This positional contribution has a twofold aim: the first is to explore the recent empirical
literature developed around the issue of how the adoption of new technologies within the
firm has changed the skill requirements of occupations; the second is to conjecture on the
relationship, and on the relative sign, between technology adoption and firm sponsored onthe-
job training. The basic idea is that the time-consuming dimension of the adoption
process plays a direct role both in determining the profitability of the investment in new
technology and in assessing the size of the productivity slowdown the firm eventually
occurs after its introduction. On the extent that the timing of adoption depends on the
workers’ skill composition and on the distance between the skills acquired for the job and
the skills required by the job, the deep understanding of the interplay between the
mechanisms of human capital accumulation can be helpful in order for the firm to set
suitable and efficient job-training strategies. During the last two decades the discussion
around the impact of technological change on workers’ human capital has been intense: the
rapid diffusion of information and communication technologies (ICT) and computer-based
machines (CNC, CAD), together with the large increase in the supply of highly-educated
workers and rising returns to education, favoured the argument that technological change is
characterized by a skill-biased nature (SBTC), leading to substantial changes in the division
of labour and shifting labor demand towards employees with higher levels of education. On
this purpose, different approaches have developed in the last decades that provide different
evidence to a common research question. While a lot of national and international evidence
still continues to support the SBTC hypothesis by employing ‘traditional’ aggregate
measures of technological change and indirect measures of skill upgrading, a smaller
literature is emerging that considers the heterogeneity of both technologies and skills at the
workplace and aims at determining the demand of skills by the tasks occupations require.
Even if new and interesting results emerge, many ‘black holes’ still remain, the most
important of which seem to be the lack of theoretical and empirical models analyzing the
role that school education and on-the-job training, and their interplay, can play in reducing
the timing of new technology
title: Гражданско-правовое регулирование продажи лекарственных средств дистанционным способом: последствия пандемии Covid-19
Creators: name: Гунба, А. М.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: Статья посвящена анализу нормативного регулирования вопросов реализации лекарственных препаратов через сеть Интернет. Автором рассматривается национальное законодательство, регулирующее дистанционную куплю-продажу лекарственных средств, дается оценка нововведениям, вызванным необходимостью реализации лекарств в период пандемии COVID-19, делаются выводы о целесообразности легализации торговли
лекарствами в интернет-ресурсах.
N-beta-methylamino-L-alanine : a non-protein amino acid incorporated into protein
Creators: name: Glover, William Broc
Publisher: name: University of British Columbia
Year: 2014

description: N-β-methylamino-L-alanine (BMAA) is a naturally-occurring toxin produced in cyanobacteria that has been linked to neurological degeneration. Efforts to study and quantify BMAA in the environment are hampered by two biologically-occurring isomers, N-(2- aminoethyl)glycine (AEG) and 2,4-diaminobutyric acid (DAB), that exist in very low concentrations in many sample matrices, indicating a need for improved analytical methods. The first objective of this thesis is to develop an accurate, precise and sensitive method for the analysis of BMAA and the isomers AEG and DAB that is applicable to a wide variety of sample matrices. A method for complete chromatographic separation of the isomers was developed using chemical derivatization, reversed phase chromatography and tandem mass spectrometry, and was validated with cyanobacteria-containing natural health products. The mechanism of toxicity of BMAA is not fully understood, and previous studies have shown an association between BMAA and protein. The second objective of this thesis is to determine whether BMAA is incorporated into protein via a modified proteomics approach used to identify peptides containing BMAA in tissue from post-mortem human patients. This approach identified BMAA in proteins isolated from the frontal lobe of Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease (AD), and control patients. To determine whether BMAA incorporation into protein occurs as an error in synthesis, a cell-free expression system was challenged with a deficiency of specific amino acids and supplemented with BMAA. BMAA was incorporated into protein via an error in synthesis. Together, these data demonstrate accurate methods for quantification of BMAA, a route of exposure through dietary products, and a potential mechanism for storage of BMAA in proteins.
title: BR-UK: Equality, Diversity, Inclusion and Intersectionality Calendar
Creators: name: Martin, Sancha
name: Dawe Black, Ellie
Publisher: name: Behavioural Research UK
Year: 2025
Subjects: subject: Equality
subject: Diversity
subject: Inclusion
subject: Intersectionality
subject: calendar

description: This calendar provides a (non-exclusive) summary of public holidays, holy days, religious festivals and academic term times - some errors may exist. The dates highlighted here are not exhaustive but are a selection of diversity and inclusion dates that can help to ensure all team members feel included.
title: Прокурорский надзор за деятельностью правоохранительных органов в сфере незаконного оборота наркотиков
Creators: name: Данилова, К. А.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: В статье рассматриваются вопросы организации прокурорского надзора за соблюдением законодательства правоохранительными органами в сфере незаконного оборота наркотиков. Анализируются основные ошибки органов предварительного следствия и органов, осуществляющих оперативно-розыскную деятельность в данной сфере. Обращается внимание на вовлечение несовершеннолетних в наркобизнес. Затрагиваются
вопросы о полномочиях прокурора по изучению вещественных доказательств по уголовным делам, связанным с наркотиками. Отмечается работа таможенных органов по выявлению наркокурьеров. Рассматривается надзорная деятельность прокурора за исполнением законодательства о наркотиках исправительными учреждениями. Предлагаются способы повышения эффективности прокурорского надзора за правоохранительными органами во избежание совершения ими нарушений.
Critical Casimir forces and colloidal aggregation: A numerical study
Creators: name: Gnan, Nicoletta
name: Zaccarelli, Emanuela
name: Tartaglia, Piero
name: Sciortino, Francesco
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We present a numerical study of the effective potential $V_\mathrm{eff}$ between two hard-sphere colloids dispersed in a solvent of interacting particles, for several values of temperature and solvent density, approaching the solvent gas-liquid critical point. We investigate the stability of a system of particles interacting via $V_\mathrm{eff}$ to evaluate the locus of colloidal aggregation in the solvent phase-diagram, and its dependence on the colloid size. We assess how the excluded volume depletion forces are modified by solvent attraction and discuss under which conditions solvent critical fluctuations, in the form of critical Casimir forces, can be used to effectively manipulate colloidal aggregation.
Serjania subimpunctata Radlk.
Creators: name: Araújo, Diogo
name: Alves, Marccus
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Sapindaceae
Serjania
Serjania subimpunctata

description: 87. Serjania subimpunctata Radlk. (Fig. 3 E, F)
Brazil (Pernambuco, Sergipe, Bahia).
Selected Voucher:—Piedade, Araújo et al. 588 (UFP); Macacos, Araújo & Alves-Araújo 499 (UFP).
description: Published as part of Araújo, Diogo & Alves, Marccus, 2010, Climbing plants of a fragmented area of lowland Atlantic Forest, Igarassu, Pernambuco (northeastern Brazil), pp. 1-24 in Phytotaxa 8 on page 22, DOI: 10.11646/phytotaxa.8.1.1, http://zenodo.org/record/4893863
Phase transitions in exponential random graphs
Creators: name: Radin, Charles
name: Yin, Mei
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We derive the full phase diagram for a large family of two-parameter exponential random graph models, each containing a first order transition curve ending in a critical point.
description: Published in at http://dx.doi.org/10.1214/12-AAP907 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Impact of ceramides and penetration enhancers on the nanostructure of Stratum corneum lipid model membranes
Creators: name: Engelbrecht, Tanja Nadine
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Lipide
subject: Penetration
subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Das Stratum corneum (SC) bildet die schützende Penetrationsbarriere der menschlichen Haut. Dabei stellt die interzelluläre Lipidmatrix des SC die Hauptroute für penetrierende Stoffe dar und hat in den letzten Jahren außerordentliches Interesse ausgelöst. Die vorliegende Arbeit untersuchte den molekularen Wirkmechanismus zweier lipophiler Penetrationsenhancer unter Nutzung orientierter Lipidmodellmembranen mit einfacher Zusammensetzung. Außerdem wurde der Einfluss des Ceramid NP und eines künstlichen Ceramid EOS auf die Struktur von Modellmembranen studiert. Methodisch kamen die Neutronenstreuung zusammen mit spezifischer Deuterium-Markierung für die Strukturaufklärung der Modellmembranen zum Einsatz, sowie DSC und FT-Raman-Spektroskopie zur Untersuchung des thermotropen Phasenverhaltens der Lipide. Die experimentellen Befunde wurden durch zusätzliche Techniken wie Deuterium-NMR-Spektroskopie und Molecular Dynamcis (MD) Simulationen abgesichert.
description: The penetration barrier of mammalian skin resides in the Stratum corneum (SC). Since the intercellular SC lipid matrix represents the major pathway for drug penetration, this remarkable lamellar structure has increasingly attracted interest during recent years. The present work addressed the issue of elucidating the molecular mode of action of two lipophilic penetration enhancers, oleic acid and isopropyl myristate by using oriented SC lipid model membranes of simplistic composition. In addition, the impact of ceramide NP and an artificial CER[EOS] on the structure of the SC lipid model membranes was studied. Different methodological approaches were applied such as neutron diffraction combined with deuterium labelling for elucidating the membrane nanostructure, DSC and FT Raman spectroscopy for the investigation of the thermotropic phase behaviour of the lipids. The experimental findings were confirmed using additional techniques like 2H NMR spectroscopy and MD simulations.
Asymptotic completeness for infraparticles in two-dimensional conformal field theory
Creators: name: Dybalski, Wojciech
name: Tanimoto, Yoh
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 81T05, 81T40, 81U99

description: We formulate a new concept of asymptotic completeness for two-dimensional massless quantum field theories in the spirit of the theory of particle weights. We show that this concept is more general than the standard particle interpretation based on Buchholz' scattering theory of waves. In particular, it holds in any chiral conformal field theory in an irreducible product representation and in any completely rational conformal field theory. This class contains theories of infraparticles to which the scattering theory of waves does not apply.
description: 17 pages, no figure
Methoden und Algorithmen für die Systems Biology Graphical Notation
Creators: name: Czauderna, Tobias
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2015
Subjects: subject: Systembiologie
subject: Visualisierung
subject: Netzwerk
subject: Online-Publikation
subject: Hochschulschrift
subject: 004
subject: 570

description: Die Systems Biology Graphical Notation (SBGN) ist ein Standard für die visuelle Darstellung von Prozessen und Netzwerken in der Systembiologie. Drei SBGN-Sprachen (PD, ER und AF) ermöglichen es, verschiedene Aspekte biologischer Systeme in unterschiedlichen Detailstufen als SBGN-Karten darzustellen. In dieser Dissertation werden Methoden und Algorithmen zur Unterstützung der Arbeit mit SBGN-Karten beschrieben. Dabei werden Aspekte wie die Übersetzung von Stoffwechselweg-Karten der KEGG-Datenbank in SBGN PD-Karten einschließlich automatischen Layouts und die Umwandlung von SBGN PD-Karten in SBGN AF-Karten besprochen. Zusätzlich wird das Konzept der SBGN Bricks, wiederverwendbarer Module, die spezifische biologische Prozesse repräsentieren, vorgestellt. Die aufgeführten Methoden und Algorithmen sowie weitere Methoden zur Arbeit mit SBGN-Karten wurden in der Software SBGN-ED implementiert. Anhand einiger Beispiele wird die Anwendung der entwickelten Methoden und Algorithmen dargestellt.
description: The Systems Biology Graphical Notation (SBGN) is a standard for the visual representation of processes and networks in systems biology. Three SBGN languages (PD, ER, and AF) allow for the representation of different aspects of biological systems at different levels of detail as SBGN maps. This PhD thesis describes methods and algorithms supporting the use of SBGN maps. In particular it discusses problems such as the translation of pathway maps from the KEGG database into SBGN PD maps including automatic layout and the conversion of SBGN PD maps into SBGN AF maps. In addition, the concept of the SBGN Bricks, reusable modules which represent specific biological processes, is presented. The methods and algorithms given above as well as other techniques for creating and editing of SBGN maps have been implemented in the software SBGN-ED. Examples are presented showing the application of the developed methods and algorithms.
La singularitée Partagée
Creators: name: nowak, Gabriel
Publisher: name: Gabriel Nowak
Year: 2025

description:  Ce manuscrit explore une théorie alternative de la gravité et de la structure de l’univers, reposant sur un champ scalaire noté Φ(xμ) , représentant une résonance locale avec une entité géométrique universelle appelée Singularité Partagée.Il s’agit d’une proposition originale combinant rigueur mathématique, exploration physique et ouverture philosophique.
title: Εξόρυξη, ανάλυση και οπτικοποίηση εκπαιδευτικών δεδομένων από πλατφόρμες ηλεκτρονικής μάθησης
title: Extraction, analysis and visualization of educational data from e-learning platforms
titleType: AlternativeTitle
Creators: name: Σιάφης, Βησσαρίων
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2021
Subjects: Πλατφόρμες ηλεκτρονικής μάθησης
Πληροφοριακά συστήματα
Ηλεκτρονική μάθηση
Μικτή μάθηση
Εξόρυξη δεδομένων
Οπτικοποίηση δεδομένων
Εκπαιδευτικά δεδομένα
Ανθρωποκεντρικός υπολογισμός
Εμπειρικές μελέτες

description: Η συσσώρευση μεγάλου όγκου ετερογενών δεδομένων και η ραγδαία ανάπτυξη των τεχνολογιών εξόρυξης τους υπέδειξε τη δυνατότητα υιοθέτησης τους και στην εκπαίδευση. Πρόσφατα πλήθος μελών των εκπαιδευτικών κοινοτήτων επέδειξε αξιοσημείωτη δραστηριότητα στην εξερεύνηση, διαχείριση και ενσωμάτωση δεδομένων προερχομένων από μεγάλες εκπαιδευτικές συλλογές οι οποίες εμπεριέχουν επωφελή γνώση. Στο πλαίσιο αυτό η εξόρυξη εκπαιδευτικών δεδομένων βρίσκεται στη διασταύρωση των επιστημών της πληροφορικής, της εκπαίδευσης και της στατιστικής και επικεντρώνεται στην ανάπτυξη και εφαρμογή μεθόδων και τεχνικών για την ανακάλυψη νέων μοντέλων και την εξαγωγή πληροφοριών από εκπαιδευτικά δεδομένα. Μεταξύ των πολλών συστημάτων διαχείρισης μάθησης που έχουν αναπτυχθεί, το Moodle αποτελεί κυρίαρχο και δημοφιλές σύστημα κατέχοντας το μεγαλύτερο μερίδιο χρήσης στον ακαδημαϊκό χώρο. Η χαμηλή τεχνική πολυπλοκότητα που διαθέτει και η ποικιλία δομικών μονάδων και δραστηριοτήτων που υποστηρίζει αποτελούν ορισμένα μόνο από τα δημοφιλή κριτήρια επιλογής του. Η έρευνα αυτή έχει ένα διττό στόχο. Ο πρώτος αφορά σε επιλογή και ενσωμάτωση ειδικών μονάδων (block) και πρόσθετων αναφορών στο περιβάλλον Moodle και η μετέπειτα εφαρμογή τους σε πραγματικά δεδομένα του μεταπτυχιακού μαθήματος με τίτλο «Συστήματα Ηλεκτρονικής Μάθησης & Εξ’ Αποστάσεως Εκπαίδευσης» του μεταπτυχιακού προγράμματος «Τεχνολογίες Πληροφοριών & Επικοινωνιών για την Εκπαίδευση» που προσφέρεται από κοινού από τα Πανεπιστήμια Αθηνών, Θεσσαλίας και Δυτικής Αττικής. Ο δεύτερος αφορά σε αξιοποίηση των εξωτερικών εργαλείων Gephi, Weka, ProM και Javascript Infovis Toolkit στην εξόρυξη και οπτικοποίηση πληροφοριών σε προγενέστερο ή/ και πραγματικό χρόνο εκπαιδευτικών δεδομένων προερχομένων από το ίδιο μεταπτυχιακό μάθημα που προσφέρεται στο moodle. Σε αυτήν την κατεύθυνση, η παρούσα μελέτη εφαρμόζει πειραματικά και συγκρίνει δημοφιλή εργαλεία εξόρυξης δεδομένων και οπτικοποίησης στα δεδομένα του μαθήματος. Τα αποτελέσματα αυτής της ανάλυσης επισημαίνουν την ανάγκη για συνδυασμένη χρήση περισσότερων από ένα μεμονωμένων εργαλείων, προκειμένου να καταγραφεί μια ολοκληρωμένη εικόνα των δεδομένων και να αποκαλυφθούν οι σχέσεις μεταξύ των εμπλεκομένων μεταβλητών.
La singularitée Partagée
Creators: name: nowak, Gabriel
Publisher: name: Gabriel Nowak
Year: 2025

description: Ce document vise à tester, par des moyens mathématiques et astrophysiques, la cohérence d’une hypothèse théorique formulée dans un manuscrit précédent : celle de la Singularité Partagée — une structure géométrique universelle connectée à chaque point de l’espace-temps via un champ scalaire Φ(x^μ).

Dans ce travail, nous explorons une démarche scientifique indépendante : en intégrant un champ Φ(r) simple dans les équations gravitationnelles, nous cherchons à reproduire les courbes de rotation de galaxies spirales, sans faire appel à la matière noire. En comparant les prédictions obtenues à partir de ce champ avec les observations de NGC 3198 et NGC 2403, nous examinons si cette hypothèse produit des résultats cohérents.

L’objectif ici n’est pas de démontrer la théorie de la Singularité Partagée, mais de vérifier empiriquement si un champ Φ, inspiré de cette idée, peut expliquer certains phénomènes astrophysiques mesurables.
La singularitée Partagée
Creators: name: nowak, Gabriel
Publisher: name: Gabriel Nowak
Year: 2025

description: Ce document annexe présente l’extension des travaux décrits dans « La Singularité Partagée – Thèse », en intégrant l’analyse de nouvelles galaxies et l’exploration de différentes formes du champ scalaire Φ(r).
Ductile extrusion, underplating, and out-of-sequence thrusting within the Himalayan metamorphic core, Kanchenjunga, Nepal
Creators: name: Ambrose, Tyler Kurtis
Publisher: name: University of British Columbia
Year: 2014

description: The Himalayan Metamorphic Core (HMC) is a package of greenschist to granulite grade metamorphic rocks that was buried to midcrustal levels and subsequently exhumed during Himalayan orogenesis. Until recently, most kinematic models for burial and exhumation have focused on the two fault systems that bound the HMC: the South Tibetan detachment system above and the Main Central thrust below. Increasing chronologic and thermobarometric data from across the HMC indicate that a significant amount of horizontal shortening and vertical thickening was accommodated along structures within the HMC. These structures have only a cryptic surface expression; they are often recognized in P-T-t(-D) paths only after fieldwork has been completed. Although such P-T-t(-D) discontinuities have been identified along the length of the Himalaya, little is yet known about how they developed and their overall importance to the evolution of the orogen. The Kanchenjunga region of far north-eastern Nepal exposes a thick section of garnet + biotite to migmatitic, K-feldspar + sillimanite grade paragneisses of the HMC. Pseudosection modelling and in-situ laser ablation split-stream U-Th/Pb monazite petrochronology methods were applied to anatectic paragneisses from this area to identify and elucidate cryptic structures within the HMC. The resulting P-T-t paths confirm previously reported discontinuities and reveal the presence of others previously unidentified. Our data outline a series of thrust sense discontinuities that record an early protracted history of ductile extrusion (ca. 41-21 Ma) and a later history of underplating that drove metamorphism in the footwall material (ca. 31-12 Ma). These structures were repeated by early Miocene (ca. 20-18 Ma) out-of-sequence thrusting coincident with the previously mapped High Himal thrust. The resulting kinematic model for the evolution of the HMC in the Kanchenjunga area demonstrates that the HMC is significantly more complex than a thick package of homoclinal rocks bound between two faults. Understanding the internal structure of the HMC is critical to elucidating the kinematics of the orogen and convergence accommodation processes in general.
A parameter estimation framework for kinetic models of biological systems
Creators: name: Baker, Syed Murtuza
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Framework
subject: Parameterschätzung
subject: Identifikation
subject: Biologisches Modell
subject: Online-Publikation
subject: Hochschulschrift
subject: 004

description: Das in dieser Arbeit vorgeschlagene Framework besteht aus zwei Modulen, eines zur Parameterschätzung und eines zur Identifiability-analyse. Das erstere enthält eine neue, stabile Filtermethode, CSUKF, welche die A-posteriori-Wahrscheinlichkeitsverteilung unter Einhaltung der Zustandsbeschränkungen verwendet. Hierbei berücksichtigt sie sowohl Systemrauschen als auch Rauschen in den Messungen. Das Identifiability-modul enthält verschiedene datenorientierte Methoden, welche helfen, nicht-identifizierbare Parameter zu finden und bei deren Behebung unterstützen. Diese Submodule ordnen die Parameter in Abhängigkeit ihrer Sensitivität gegenüber dem Model output, zeigen sowohl strukturell als auch praktisch nicht identifizierbare Parameter auf und können weitere Messungen vorschlagen, um die Nicht-identifizierbarkeit zu beheben. Sind weitere Messungen nicht möglich wird basierend auf subjektiver Unsicherheit ein informative prior erstellt, um diese Parameter zu identifizieren. Das Framework wurde erfolgreich bei drei biologischen Modellen benutzt, um Parameter abzuschätzen.
description: This thesis proposes a parameter estimation framework that has two modules, the parameter estimation module and the identifiability analysis module. The parameter estimation module contains a mathematically stable novel filtering technique named CSUKF that propagates the posterior probability distribution while satisfying the state constraints. It takes both the system and measurement noise into consideration. The identifiability analysis module composed of several data oriented submodules can identify the non-identifiable parameters and can direct towards possible solutions. These submodules rank the parameters depending on their sensitivity towards model output, identifies both the structurally and practically non-identifiable parameters and can then direct towards possible solutions to this non-identifiability by suggesting possible extra measurements. If no extra measurement is possible then an informative prior is formulated based on subjective uncertainty which can then uniquely identify the parameters. The framework is applied successfully to three different biological models in order to estimate the parameters.
Latent protein trees
Creators: name: Henao, Ricardo
name: Thompson, J. Will
name: Moseley, M. Arthur
name: Ginsburg, Geoffrey S.
name: Carin, Lawrence
name: Lucas, Joseph E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Unbiased, label-free proteomics is becoming a powerful technique for measuring protein expression in almost any biological sample. The output of these measurements after preprocessing is a collection of features and their associated intensities for each sample. Subsets of features within the data are from the same peptide, subsets of peptides are from the same protein, and subsets of proteins are in the same biological pathways, therefore, there is the potential for very complex and informative correlational structure inherent in these data. Recent attempts to utilize this data often focus on the identification of single features that are associated with a particular phenotype that is relevant to the experiment. However, to date, there have been no published approaches that directly model what we know to be multiple different levels of correlation structure. Here we present a hierarchical Bayesian model which is specifically designed to model such correlation structure in unbiased, label-free proteomics. This model utilizes partial identification information from peptide sequencing and database lookup as well as the observed correlation in the data to appropriately compress features into latent proteins and to estimate their correlation structure. We demonstrate the effectiveness of the model using artificial/benchmark data and in the context of a series of proteomics measurements of blood plasma from a collection of volunteers who were infected with two different strains of viral influenza.
description: Published in at http://dx.doi.org/10.1214/13-AOAS639 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Schauder estimates, Harnack inequality and Gaussian lower bound for Kolmogorov type operators in non-divergence form
Creators: name: Di Francesco, Marco
name: Polidoro, Sergio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2006
Subjects: MAT/05 Analisi matematica

description: We prove some Schauder type estimates and an invariant Harnack 
inequality for a class of degenerate evolution operators of Kolmogorov type. We also prove a Gaussian lower bound for the 
fundamental solution of the operator and a uniqueness result for the Cauchy problem. The proof of the lower bound is obtained by solving a suitable optimal control problem  and using the invariant Harnack inequality.
A Triplectic Bi-Darboux Theorem and Para-Hypercomplex Geometry
Creators: name: Batalin, Igor A.
name: Bering, Klaus
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences
subject: 37J99, 53D99, 55R10, 57R30, 58C50, 70S05

description: We provide necessary and sufficient conditions for a bi-Darboux Theorem on triplectic manifolds. Here triplectic manifolds are manifolds equipped with two compatible, jointly non-degenerate Poisson brackets with mutually involutive Casimirs, and with ranks equal to 2/3 of the manifold dimension. By definition bi-Darboux coordinates are common Darboux coordinates for two Poisson brackets. We discuss both the Grassmann-even and the Grassmann-odd Poisson bracket case. Odd triplectic manifolds are, e.g., relevant for Sp(2)-symmetric field-antifield formulation. We demonstrate a one-to-one correspondence between triplectic manifolds and para-hypercomplex manifolds. Existence of bi-Darboux coordinates on the triplectic side of the correspondence translates into a flat Obata connection on the para-hypercomplex side.
description: 31 pages, LaTeX. v2: Changed title; Added references. v3: Minor reorganization of paper
title: Συγκριτική διερεύνηση γνώσεων και αντιλήψεων σε θέματα ανακύκλωσης μεταξύ δείγματος πληθυσμών Ελλάδας και Αγγλίας
title: Comparative investigation of knowledge and perceptions on issues of recycling between a sample of the Greek and English people
titleType: AlternativeTitle
Creators: name: Τσιγκινοπούλου, Λήδα-Βαρβάρα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2021
Subjects: Ανακύκλωση
Ελλάδα
Αγγλία
Ερωτηματολόγιο
Διαχείριση αποβλήτων

description: Η παρούσα μεταπτυχιακή διπλωματική εργασία πραγματεύεται την διαδικασία της ανακύκλωσης. Η διαχείριση των απορριμμάτων αποτελεί ένα από τα πλέον σύνθετα και δύσκολα προβλήματα που καλείται να αντιμετωπίσει η χώρα μας, όπως και κάθε σύγχρονη κοινωνία. Η Ευρωπαϊκή Ένωση έχει πλέον μια νέα και διαφορετική στρατηγική για τη διαχείριση των αποβλήτων σκοπεύοντας τη μείωση καθώς και την αξιοποίηση τους με αποτέλεσμα η προώθηση της ανακύκλωσης να είναι επιβεβλημένη. Καθώς πληθαίνουν οι άνθρωποι στην γη, αυξάνουν και οι ανάγκες τους. Όμως η υπερκατανάλωση δηλαδή η χρήση πολύ περισσοτέρων πόρων από όσους χρειάζονται παράγει πολύ μεγάλες ποσότητες σκουπιδιών με αποτέλεσμα την καταστροφή του περιβάλλοντος. Αυτό το πρόβλημα θα μπορούσε να αντιμετωπιστεί είτε με την μείωση της κατανάλωσης λύση που δεν είναι εύκολα πραγματοποιήσιμη είτε με την ανακύκλωση. Σκοπός της εργασίας αυτής είναι να διερευνήσουμε τον τρόπο που οι άνθρωποι αντιλαμβάνονται την έννοια της ανακύκλωσης και πως στη συνέχεια αυτή η αντίληψη μετουσιώνεται σε πράξη περιβαλλοντικής συνείδησης. Σε αυτή την έρευνα συμμετείχαν 292 άτομα από την Ελλάδα και 30 άτομα από το Ηνωμένο Βασίλειο απαντώντας σε ένα ερωτηματολόγιο που συγκρίνει τις τεχνικές ανακύκλωσης που χρησιμοποιούνται σήμερα στην Ελλάδα με αυτές του Ηνωμένου Βασιλείου καθώς και πόσο γνώστες είναι του θέματος. Συμπερασματικά, στην Ελλάδα υπάρχει μεγάλη έλλειψη ενημέρωσης σχετικά με την καθημερινή ανακύκλωση. Γεγονός το οποίο δηλώνει ότι η ελπίδα για το μέλλον της νέας γενιάς αναπτερώνεται όταν ένα μικρό παιδί μαθαίνει πώς να χρησιμοποιεί σωστά τους τον σχετικούς κάδους, εναποθέτοντας ένα ανακυκλώσιμο προϊόν.
Perceptions of Risk Management Practices through the reading of public corporate financial documents
Creators: name: Aureli, Selena
name: Salvatori, Federica
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: SECS-P/07 Economia aziendale

description: The demand for risk management and risk disclosure has increasingly intensified, especially in the aftermath of the financial crisis. Despite the several advantages of risk reporting, companies may withhold information for many reasons. Accordingly, the present research investigates whether and how public disclosure supports stakeholders in understanding the risks and the risk management currently in practice. Secondly, it aims to understand whether the quality and quantity of risk disclosure is related to the maturity of the risk management systems adopted. Content analysis and questionnaires have been combined, focusing on Italian listed local utilities, which are exposed to several different risks. Results show that information mainly regard risks and specific company responses adopted and that there is not always a direct correspondence between the degree of corporate risk disclosure and the maturity of risk management practices implemented by the firm.
Risk Disclosure in Sustainability Reports of Italian Public Utilities
Creators: name: Aureli, Selena
name: Salvatori, Federica
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2012
Subjects: SECS-P/07 Economia aziendale

description: Corporate Social Responsibility may be seen as an essential element of corporate risk management contributing to a company’s survival. 
The link between CSR and risk management is even deeper in public utilities because they have to be accountable while carrying out activities that potentially impact on the current and future citizenry. The presence of local governments or/and the State as Italian utilities’ shareholders may  lead those companies to disclose even more information than private ones, although a difference in sustainability disclosure may be found when the closeness of the relationship with the local communities is weaken. 
Accordingly, this paper investigates the features of the risk disclosure within the sustainability reports of Italian utilities companies listed at the Milan Stock Exchange, while detecting the role played by the local government or State ownership in this issue.
title: Право застройки в России
Creators: name: Зырянов, Г. Д.
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2021

description: Статья посвящена анализу развития права застройки и его месту в системе современного вещного права России. Автором проведён критический анализ права застройки в различных периодах его существования, выделены современные проблемы его практического применения с учетом содержания законопроектов, предусматривающих его восстановление в гражданском законодательстве.
Il distretto come modello intersettoriale di sviluppo del territorio
Creators: name: Mariotti, Alessia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2007
Subjects: M-GGR/02 Geografia economico-politica

description: Partendo dalla descrizione del distretto industriale come modello di interpretazione della complessità territoriale, il presente saggio vuole fornire qualche spunto di riflessione sulla valenza scientifica di tale approccio nella sua applicazione ad altri settori dell’economia, rispetto a quelli più propriamente produttivi. La lettura del territorio e più precisamente delle potenzialità di sfruttamento efficiente delle sue risorse al fine di favorirne lo sviluppo, può passare attraverso l’applicazione di alcuni degli aspetti fondamentali del distretto industriale ad aree di interesse che recentemente hanno visto aumentare la loro importanza relativa nelle scelte di politica economica: la cultura ed il turismo. Saranno posti quindi in evidenza i punti di forza e di debolezza di questo modello nelle sue implicazioni territoriali, sociali ed economiche legate a questi due settori trasversali.
Contributo per una conoscenza analitica delle Mura Bolognesi: Il rilievo critico
Creators: name: Galli, Claudio
name: Grilli, Matteo
name: Lugli, Fabio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2006
Subjects: ICAR/19 Restauro

description: Per la prima volta viene affrontato in modo critico e definito il rilievo diretto delle mura e delle porte della terza cerchia di Bologna. La restituzione grafica del testo architettonico è fondamentale non solo per gli studi sui materiali e sulle tecniche che compongono i vari manufatti afferenti al sistema fortificato, ma anche per una lettura cronologica delle stratificazioni che si sono sedimentate nel corso dei secoli. In particolare vengono analizzate direttamente sul testo architettonico le fasi costruttive di Porta Mascarella e Porta San Donato e vengono comparate fra loro cartografie inedite relative alla struttura geometrica delle mura con i relativi elementi accessori, quali cancella, fossato, terrapieni, ecc..