cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Early-onset Alzheimer’s disease versus frontotemporal dementia: resolution with genetic diagnoses?
Creators: name: Mochtar Pribadi
name: Coppola, Giovanni
name: Geschwind, Daniel H.
name: Rabinovici, Gil D.
name: Miller, Bruce L.
name: Suzee E. Lee
name: Sha, Sharon J.
name: Khazenzon, Anna M.
name: Ghosh, Pia M.
name: Rankin, Katherine P.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Medicine
subject: Biochemistry

description: ABSTRACTWe report a diagnostically challenging case of a 64-year-old man with a history of remote head trauma who developed mild behavioral changes and dyscalculia. He was diagnosed with clinical Alzheimer’s disease (AD), with additional features consistent with behavioral variant frontotemporal dementia. Structural magnetic resonance imaging revealed atrophy in bilateral frontal and parietal cortices and hippocampi on visual inspection and left frontal pole and bilateral anterior temporal encephalomalacia, suspected to be due to head trauma. Consistent with the diagnosis of Alzheimer’s pathology, positron emission tomography (PET) with Pittsburgh compound B suggested the presence of beta-amyloid. Fluorodeoxyglucose PET demonstrated hypometabolism in bilateral frontal and temporoparietal cortices. Voxel-based morphometry showed atrophy predominant in ventral frontal regions (bilateral orbitofrontal cortex, pregenual anterior cingulate/medial superior frontal gyrus), bilateral mid cingulate, bilateral lateral temporal cortex, and posterior insula. Bilateral caudate, thalamus, hippocampi, and cerebellum were prominently atrophied. Unexpectedly, a pathologic hexanucleotide repeat expansion in C9ORF72 was identified in this patient. This report underscores the clinical variability in C9ORF72 expansion carriers and the need to consider mixed pathologies, particularly when imaging studies are inconsistent with a single syndrome or pathology.
Crop sward structure explains seasonal variation in nest site selection and informs agri-environment scheme design for a species of high conservation concern: the Corn Bunting Emberiza calandra
Creators: name: Perkins, Allan J.
name: Maggs, Hywel E.
name: Wilson, Jeremy D.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Evolutionary Biology

description: Capsule Corn Buntings nested in tall dense grasses and cereals, selecting for sward density over height, and cereal fields with high weed scores.Aims To measure the vegetation attributes of fields selected as nest sites by Corn Buntings, to inform the design of safe nesting habitat measures in agri-environment schemes for this rapidly declining ground-nesting passerine.Methods Nesting activity was monitored across 32 farms in eastern Scotland during 2004–09. Land use and singing males were mapped to measure habitat availability for nesting females within their mate's territory, and crop swards measured. Effects of sward characteristics on field selection for nesting, and seasonal variation in crop use, were modelled.Results Nests (95% of 580) were mainly in cereals and grasses. Taller denser swards were selected, with sward density a stronger predictor of field use than sward height, and cereal field use strongly associated with high weed scores. Variation in sward structure between crop types, and changes due to crop maturation or harvesting, largely explained seasonal patterns in crop use.Conclusion Conservation measures targeting nesting Corn Buntings should provide uncut or late-cut grasses or cereals 30–100 cm tall with a dense ground layer of weeds or crop vegetation.
Photometric recovery of crowded stellar fields observed with HST/WFPC2 and the effects of confusion noise on the extragalactic distance scale
Creators: name: Ferrarese, Laura
name: Silbermann, N. A.
name: Mould, Jeremy
name: Stetson, Peter B.
name: Saha, Abhijit
name: Freedman, Wendy L.
name: Kennicutt, Robert C.
Publisher: name: Swinburne
Year: 2024

description: We explore the limits of photometric reductions of crowded stellar fields observed with the Wide Field and Planetary Camera 2 on board the Hubble Space Telescope. Two photometric procedures, based on the DoPHOT and DAOPHOT/ALLFRAME programs, are tested, and the effects of crowding, complex sky background, and cosmic-ray contamination are discussed using an extensive set of artificial star simulations. As a specific application of the results presented in this paper, we assess the magnitude of photometric biases on programs aimed at finding Cepheids and determining distances. We find that while the photometry in individual images can be biased too bright by up to 0.2 mag in the most crowded fields due to confusion noise, the effects on distance measurements based on Cepheid variables are insignificant, less than 0.02 mag (1% in distance) even in the most problematic cases. This result, which is at odds with claims that have recently surfaced in the literature, is due to the strict criteria applied in the selection of the variable stars, and the photometric cross-checks made possible by the availability of multiple exposures in different filters which characterize Cepheid observations.
Towards the quark-gluon plasma Equation of State with dynamical strange and charm quarks
Creators: name: Burger, Florian
name: Ilgenfritz, Ernst-Michael
name: Lombardo, Maria Paola
name: Müller-Preussker, Michael
name: Trunin, Anton
Publisher: name: Humboldt-Universität zu Berlin
Year: 2016
Subjects: subject: 530 Physik

description: We present an ongoing project aimed at determining the thermodynamic Equation of State (EoS) of quark-gluon matter from lattice QCD with two generations of dynamical quarks. We employ the Wilson twisted mass implementation for the fermionic fields and the improved Iwasaki gauge action. Relying on T = 0 data obtained by the ETM Collaboration the strange and charm quark masses are fixed at their physical values, while the pion mass takes four values in the range from 470 MeV down to 210 MeV. The temperature is varied within a fixed-lattice scale approach. The values for the pseudocritical temperature are obtained from various observables. For the EoS we show preliminary results for the pure gluonic contribution obtained at the pion mass value 370 MeV, where we can compare with previously obtained results with Nf = 2 degenerate light flavours.
Preparation, stability and flavor formation profile of Amadori rearrangement products of glycine, diglycine, triglycine and glucose
Creators: name: Luo, Yue
Publisher: name: No Publisher Supplied
Year: 2024

description: Amadori rearrangement products are potential flavor additives with various advantages such as relatively good stability, green production, and the capability of producing fresh and desirable favors, with a good chance to replace traditional unstable flavor constituents, especially the Maillard reaction products (MRPs). Although some research showed that ARPs can serve as promising flavor additives, a lack of systematic investigation is obvious, and more attention needs to be paid to ARPs. Besides, a certain number of amino acid-Amadori rearrangement products (ARPs) have been studied, but there is still a lack of knowledge of oligopeptide-ARPs. Filling the gap should be a great step in the potential usage of ARP as future flavor additives. This study explored an amenable way to prepare pure ARPs on a large scale with a high yield and found that reducing water content methods worked such as freeze-drying and vacuum dehydration coupled with low-temperature heating. What is more, glycine-, diglycine-, and triglycine-glucose-ARPs were compared for stability and flavor generation in an aqueous system at different temperatures and initial pH values. Oligopeptide-ARPs exhibited relatively weaker stability than amino acid-ARPs. The degradation is positively related to temperature, heating time, and peptide length due to more energy input and more possible bond linkage breakdown sites. Contrastively, oligopeptide-ARPs displayed better flavor formation ability than amino acid-ARPs. ARPs produced similar flavor profiles as MR systems but were capable of producing at lower temperatures, showing easier flavor generation ability than corresponding Maillard systems.Besides, oligopeptides (diglycine and triglycine) exhibited better relative reactivity of ARP formation than an amino acid (glycine) at relatively low temperatures such as 80 and 100 ℃ and in a wide range of pH from acidic to neutral conditions, but the result reversed at high temperatures for severer instability of oligopeptide-ARPs. The relative reactivity of ARP formation of amino compounds in competing Maillard systems results from dynamic systems with various factors including the chemical characterization and composition of intrinsic reactants, and parameters of matrix conditions like pH, temperature, and thermal treatment time among others. Overall, ARPs have great potential to serve as food flavor additives, but more research is needed to get a comprehensive understanding.
A new oxolane from Enterobacter cloacae
Creators: name: Ann-Chee Yap
name: Kok-Gan Chan
name: Kae-Shin Sim
name: Yeun-Mun Choo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Enterobacter cloacae is a highly pathogenic Gram-negative proteobacterium which is responsible for a wide array of infections. In the present study, the fermentation culture of E. cloacae has yielded one new oxolane compound, Rimboxo (1) in addition to three known compounds, i.e. Maculosine (2), phenylacetic acid (3) and methyl myristate (4). These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations.
Humic acid removal by electrocoagulation: characterization of aluminum species and humic acid
Creators: name: Palacios, Ronna Jane S.
name: Do-Gun Kim
name: Seok-Oh Ko
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: In this study, the different aluminum (Al) species generated during electrocoagulation (EC), the humic acid (HA) removal, and the change in HA characteristics were evaluated. The results show that the distribution of monomeric Al species (Ala), medium polymer Al species (Alb), and colloidal or solid Al species (Alc) was dependent on initial pH and current density (CD). The higher the fraction of Alb and Alc, the faster the HA removal. The fraction of Alb and HA removal rates were higher at an initial pH of 4.5 than at 6.5. At a CD of 29 A m−2, the fraction of Alb and Alc was higher and HA removal was faster than at 5 A m−2. The results of UV/Vis spectroscopy, fluorescence spectroscopy, and size-exclusion chromatography show a decrease in aromaticity, degree of conjugation, and average molecular weight after EC treatment. The decreases were more pronounced at a high CD than at a low CD, indicating that Alb and Alc, especially Alc, contribute much to the preferential removal of highly condensed and high molecular weight structures of HA by adsorption and patch coagulation.
Analysis of the performance of test statistics for detection of outliers (additive, innovative, transient, and level shift) in AR (1) processes
Creators: name: Urooj, Amena
name: Asghar, Zahid
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Outlier detection has always been of interest for researchers and data miners. It has been well researched in different knowledge and application domains. This study aims at exploring the correctly identifying outliers using most commonly applied statistics. We evaluate the performance of AO, IO, LS, and TC as vulnerability to spurious outliers by means of empirical level of significance (ELS), power of the test indicating the sensitivity of the statistical tests in detecting changes and the vulnerability to masking of outliers in terms of misspecification frequencies are determined. We have observed that the sampling distribution of test statistic ηtp; tp = AO, IO, LS, TC in case of AR(1) model is connected with the values of n and φ. The sampling distribution of ηTC is less concentrated than the sampling distribution of ηAO, ηIO, and ηLS. In AR(1) process, empirical critical values for 1%, 5%, and 10% upper percentiles are found to be higher than those generally used. We have also found the evidence that the test statistics for transient change (TC) needs to be revisited as the test statistics ηTC is found to be eclipsed by ηAO, ηLS and ηIO at different δ values. TC keeps on confusing with IO and AO, and at extreme δ values it just gets equal to AO and LS.
A new oxolane from Enterobacter cloacae
Creators: name: Ann-Chee Yap
name: Kok-Gan Chan
name: Kae-Shin Sim
name: Yeun-Mun Choo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Enterobacter cloacae is a highly pathogenic Gram-negative proteobacterium which is responsible for a wide array of infections. In the present study, the fermentation culture of E. cloacae has yielded one new oxolane compound, Rimboxo (1) in addition to three known compounds, i.e. Maculosine (2), phenylacetic acid (3) and methyl myristate (4). These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations.
From 'sustainable development' to 'ecological civilization': winning the war for survival
Creators: name: Gare, Arran
Publisher: name: Swinburne
Year: 2024

description: The central place accorded the notion of ‘sustainable development' among those attempting to overcome ecological problems could be one of the main reasons for their failure. ‘Ecological civilization' is proposed and defended as an alternative. ‘Ecological civilization' has behind it a significant proportion of the leadership of China who would be empowered if this notion were taken up in the West. It carries with it the potential to fundamentally rethink the basic goals of life and to provide an alternative image of the future. It could both inspire people and provide the cultural foundations for the cultural, social and economic transformations necessary to create a new world order, a world order in which humans augment rather than undermine the ecosystems of which they are part. This paper explicates these implications.
When Can We Move Forward From COVID-19? When Four Capabilities Are In Action.
Creators: name: Woods, David D.
name: Seager, Thomas P.
name: Alderson, David L.
Publisher: name: Zenodo
Year: 2020
Subjects: coronavirus, resilience, capability, reconfiguration, adaptive capacity

description: As outbreaks subside, when can jurisdictions move forward restarting normal life activities while still preventing the recurrence of new hotspots or second waves? The four capabilities outlined briefly here will allow activities to return to normal faster, even in the immediate aftermath of the current outbreaks.
description: Comments and feedback are encouraged: woods.2@osu.edu.
Humic acid removal by electrocoagulation: characterization of aluminum species and humic acid
Creators: name: Palacios, Ronna Jane S.
name: Do-Gun Kim
name: Seok-Oh Ko
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: In this study, the different aluminum (Al) species generated during electrocoagulation (EC), the humic acid (HA) removal, and the change in HA characteristics were evaluated. The results show that the distribution of monomeric Al species (Ala), medium polymer Al species (Alb), and colloidal or solid Al species (Alc) was dependent on initial pH and current density (CD). The higher the fraction of Alb and Alc, the faster the HA removal. The fraction of Alb and HA removal rates were higher at an initial pH of 4.5 than at 6.5. At a CD of 29 A m−2, the fraction of Alb and Alc was higher and HA removal was faster than at 5 A m−2. The results of UV/Vis spectroscopy, fluorescence spectroscopy, and size-exclusion chromatography show a decrease in aromaticity, degree of conjugation, and average molecular weight after EC treatment. The decreases were more pronounced at a high CD than at a low CD, indicating that Alb and Alc, especially Alc, contribute much to the preferential removal of highly condensed and high molecular weight structures of HA by adsorption and patch coagulation.
Synthesis of Siloxane-Based Polymer Brushes and Investigation As Low Ice Adhesion Coatings
Creators: name: Nguyen, Van Anh
Publisher: name: RMIT University
Year: 2024
Subjects: classificationCode: 400403
subject: Chemical engineering design
classificationCode: 400101
subject: Aerospace materials
classificationCode: 340502
subject: Natural products and bioactive compounds

description: Although ice is a natural part of the universe, ice formation on surfaces can have detrimental effects on human life, animals and plants, so scientists and industrial experts have invested significant effort to develop strategies to prevent, delay or otherwise mitigate the formation of ice. A multitude of anti-icing coatings have been developed commercially, employing various mechanisms and strategies to address ice formation. The project,“Synthesis of siloxane-based polymer brushes and investigation as low ice adhesion coatings” deals primarily with aerodynamic icing and the necessary adaptations human-created systems must incorporate to accommodate the presence of ice. The scope of this thesis is to investigate what effectsthe chemical structure, surface chemistry and topography of polysiloxane-based polymer brushes on aluminum substrates has on ice adhesion strength. Various anti-icing polysiloxane brush coatings were fabricated and applied onto aluminum substrates.The surface topography and chemistry resulting from different chemical structures were analyzedto monitor changes that affect ice adhesion. Ice adhesion was assessed in tensile mode to develop the structure – property relationships. The most attractive bis-branched polysiloxane modified surfaces displayed low surface energy (23.8 mN/m), low water contact angle hysteresis (4.0 o), and ultimately low ice adhesion strength (50 kPa) relative to uncoated aluminum (331 kPa).
MicroRNA profiling in migraine without aura: Pilot study
Creators: name: Tafuri, Emmanuele
name: Santovito, Donato
name: Nardis, Velia De
name: Marcantonio, Pamela
name: Paganelli, Camilla
name: Giannapia Affaitati
name: Bucci, Marco
name: Mezzetti, Andrea
name: Giamberardino, Maria Adele
name: Cipollone, Francesco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Marine Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Background and purpose. MicroRNAs (miRNAs) are short, non-coding RNAs whose deregulation has been shown in several human diseases, including pain states and diseases associated with increased cardiovascular (CV) risk. This study aimed at identifying differentially expressed circulating miRNAs in patients with ‘migraine without aura’ (MO), a pain condition whose link with CV risk remains debated.Methods. Fifteen female MO patients and 13 matching healthy controls underwent a circulating microRNA expression profiling. MiR-22, miR-26a, miR-26b, miR-27b, miR-29b, let-7b, miR-181a, miR-221, miR-30b, and miR-30e were selected for validation by quantitative real-time polymerase chain reaction.Results. In migraineurs versus controls, four miRNAs were differentially expressed: miR-27b was significantly up-regulated (q < 0.004), while miR-181a, let-7b, and miR-22 were significantly down-regulated (q ≤ 0.01). MiR-22 and let-7b down-regulation was also confirmed in circulating blood monocytes. A logistic regression model based on microRNA expression profile showed a high accuracy for identifying migraine (AUC of ROC curve: 0.956; P < 0.001).Conclusion. A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk.
Biosystematic studies on the mountain plant Gentiana lutea L. reveal variability in reproductive traits among subspecies
Creators: name: Rossi, Martina
name: Fisogni, Alessandro
name: Galloni, Marta
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background: Taxonomic analysis provides a basic understanding for taxon identification and contributes to preliminary information for several branches of applied biology, while studies on reproductive strategies and plant fitness are essential to interpret population status and dynamics. Aims: We tested the reliability of diagnostic characters for identification and to characterise sexual resource allocation, the breeding system and seed predation among subspecies of Gentiana lutea. Methods: We analysed morphological characters in 70 herbarium specimens. In five natural populations we counted pollen and ovule numbers, assessed reproductive output after pollination treatments and evaluated pre-dispersal predation. Results: Taxonomic traits previously indicated as diagnostic were not sufficient to discriminate among subspecies. The pollen number and pollen:ovule (P:O) ratio varied strongly among subspecies; self-pollinated flowers produced a significantly lower number of seeds than open-pollinated flowers. Retention of empty fruits and high levels of pre-dispersal seed predation were observed in every case. Conclusions: The variation of P:O ratios among subspecies suggests different efficiency in pollen transfer. The species is self-compatible, nevertheless all subspecies require pollen vectors to enhance cross pollination and viable seed production. Fruit retention may have evolved as a strategy to reduce predation, ensuring higher plant fitness.
Biosystematic studies on the mountain plant Gentiana lutea L. reveal variability in reproductive traits among subspecies
Creators: name: Rossi, Martina
name: Fisogni, Alessandro
name: Galloni, Marta
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Background: Taxonomic analysis provides a basic understanding for taxon identification and contributes to preliminary information for several branches of applied biology, while studies on reproductive strategies and plant fitness are essential to interpret population status and dynamics. Aims: We tested the reliability of diagnostic characters for identification and to characterise sexual resource allocation, the breeding system and seed predation among subspecies of Gentiana lutea. Methods: We analysed morphological characters in 70 herbarium specimens. In five natural populations we counted pollen and ovule numbers, assessed reproductive output after pollination treatments and evaluated pre-dispersal predation. Results: Taxonomic traits previously indicated as diagnostic were not sufficient to discriminate among subspecies. The pollen number and pollen:ovule (P:O) ratio varied strongly among subspecies; self-pollinated flowers produced a significantly lower number of seeds than open-pollinated flowers. Retention of empty fruits and high levels of pre-dispersal seed predation were observed in every case. Conclusions: The variation of P:O ratios among subspecies suggests different efficiency in pollen transfer. The species is self-compatible, nevertheless all subspecies require pollen vectors to enhance cross pollination and viable seed production. Fruit retention may have evolved as a strategy to reduce predation, ensuring higher plant fitness.
Ferramenta da Terapia Humanista: Prática de Integração Mente-Corpo
Creators: name: Brandl, Edenilson
Publisher: name: Zenodo
Year: 2024
Subjects: Ferramenta da Terapia Humanista
Terapia Humanista
Prática de Integração Mente-Corpo
Enciclopédia da Conscienciologia

description: Definologia: A Ferramenta da Terapia Humanista denominada prática de integração mente-corpo é uma técnica terapêutica que busca promover a harmonia e o equilíbrio entre os aspectos mentais, emocionais e físicos do ser humano, visando o desenvolvimento integral do indivíduo.
Proteomic analysis reveals KRIT1 as a modulator for the antioxidant effects of valproic acid in human bone-marrow mesenchymal stromal cells
Creators: name: Jung, Kyoung Hwa
name: Chai, Young Gyu
name: Goang-Won Cho
name: Han, Dal Mu Ri
name: Sin-Gu Jeong
name: Choi, Mi Ran
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Valproic acid (VPA) protects human bone marrow-mesenchymal stromal cells (hBM-MSCs) against oxidative stress and improves their migratory ability through increasing the secretion of trophic factors. This suggests that VPA may be an excellent candidate for improving stem cell function. However, the molecular mechanisms of VPA in BM-MSCs are not known. In this study, we used a proteomic approach to investigate VPA-associated targets under oxidative stress conditions. Krev/Rap1 interaction Trapped-1 (KRIT1), a modulator for the homeostasis of intracellular reactive oxygen species (ROS), was identified as a target protein by two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) analyses. The up-regulation of KRIT1 and its target proteins (SOD2 and FoxO1) with VPA treatment of hBM-MSCs was revealed by qPCR and immunoblot analysis. Damage from oxidative stress was reduced in VPA-pretreated BM-MSCs, which was also confirmed by qPCR and immunoblot analysis. In addition, increased in intracellular ROS by H2O2 were also reduced by VPA pretreatment in BM-MSCs. This suggests that VPA reduces intracellular ROS level by the modulation of KRIT1 and its correlated proteins, FoxO1, SOD2, and cyclin D1. Thus, this study is the first to provide evidence that VPA modulates KRIT1 and intracellular ROS in BM-MSCs.
ResearchBox 3440, 'Ostracism Threatens Certainty: Meta-Analytic Evidence', https://researchbox.org/3440
Creators: name: Andrew Hales
Publisher: name: Zenodo
Year: 2025

description: Box title: 'Ostracism Threatens Certainty: Meta-Analytic Evidence'   Reference: Andrew H. Hales , 'Ostracism Threatens Certainty: A Single-Laboratory Meta-Analysis', The Journal of Social PsychologyNote: this backup was created automatically by a ResearchBox bot
Implementation of fuzzy logic maximum power point tracking controller for photovoltaic system
Creators: name: Rahmani, Rasoul
name: Seyedmahmoudian, Mohammadmehdi
name: Mekhilef, Saad
name: Yusof, Rubiyah
Publisher: name: Swinburne
Year: 2024

description: In this study, simulation and hardware implementation of Fuzzy Logic (FL) Maximum Power PointTracking (MPPT) used in photovoltaic system with a direct control method are presented. In this controlsystem, no proportional or integral control loop exists and an adaptive FL controller generates the controlsignals. The designed and integrated system is a contribution of different aspects which includes simulation,design and programming and experimental setup. The resultant system is capable and satisfactory in termsof fastness and dynamic performance. The results also indicate that the control system works withoutsteady-state error and has the ability of tracking MPPs rapid and accurate which is useful for the suddenchanges in the atmospheric condition. MATLAB/Simulink software is utilized for simulation and alsoprogramming the TMS320F2812 Digital Signal Processor (DSP). The whole system designed andimplemented to hardware was tested successfully on a laboratory PV array. The obtained experimentalresults show the functionality and feasibility of the proposed controller.
The functionalised hexa-peri-hexabenzocoronenes by Sonogashira coupling method to modify the columnar mesophase behaviour
Creators: name: Hsiu-Hui Chen
name: Hsu-Heng Hung
name: Yu-Han Cheng
name: Jen-Wei Yu
name: Jey-Jau Lee
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Medicine
subject: Physics
subject: Biochemistry
subject: Biophysics

description: In this paper, we present a series of different thermotropic discotic columnar liquid crystalline forms of mono-substituted functionalised hexabenzocoronene (HBC) carrying five alkyl chains. Using the Sonogashira coupling reaction, 1-ethynyl-4-alkylbenzene, 1-ethynyl-4-alkoxybenzene, and alkyl-4-ethynyl benzoate groups were introduced into mono-bromohexabenzocoronenes to obtain compounds 5–7. These compounds obtained were characterised by 1H and 13C-NMR, UV-Vis, and MALDI-MS spectrometry. The thermotropic liquid crystalline (LC) properties of the compounds were investigated by polarising optical microscopy (POM), differential scanning calorimetry (DSC), and powder X-ray diffractometry (XRD).
Genetic mapping of the novel congenital loco locus on chromosome Z in Silkie Fowl chickens
Creators: name: Shiina, K.
name: Kobayashi, E.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: 1. ‘Congenital loco’ is a disorder in birds expressed at hatching, and the primary symptom is dorsal backward bending of the neck. It is a recessive disease caused by a mutation in a specific genetic locus. The following study identified a novel locus associated with congenital loco in Silkie Fowl chickens. 2. Normal and congenital loco-affected Silkie Fowl chicks exhibited no differences in the frequencies of markers on chromosome 12 adjacent to the congenital loco locus reported in a previous study in Rhode Island Red chickens. Sex determination of congenital loco-affected
chicks revealed that they were female only. 3. Bulked segregant analyses using next-generation sequencing narrowed the causative region of congenital loco to approximately 3.3 Mb between bases 9,569,012 and 12,863,792 on chromosome Z.
Causal-Consistent Reversible Debugging: Improving CauDEr
Creators: name: González-Abril, Juan José
name: Vidal, Germán
Publisher: name: arXiv
Year: 2024
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Causal-consistent reversible debugging allows one to explore concurrent computations back and forth in order to locate the source of an error. In this setting, backward steps can be chosen freely as long as they are "causal consistent", i.e., as long as all the actions that depend on the action we want to undo have been already undone. Here, we consider a framework for causal-consistent reversible debugging in the functional and concurrent language Erlang. This framework considered programs translated to an intermediate representation, called Core Erlang. Although using such an intermediate representation simplified both the formal definitions and their implementation in a debugging tool, the choice of Core Erlang also complicated the use of the debugger. In this paper, we extend the framework in order to deal with source Erlang programs, also including some features that were not considered before. Moreover, we integrate the two existing approaches (user-driven debugging and replay debugging) into a single, more general framework, and develop a new version of the debugging tool CauDEr including all the mentioned extensions as well as a renovated user interface.
description: Published as "Gonz\'alez-Abril, J.J. and Vidal, G. (2021). Causal-Consistent Reversible Debugging: Improving CauDEr. In: Morales, J.F. and Orchard, D.A. (eds) Practical Aspects of Declarative Languages. PADL 2021. Lecture Notes in Computer Science, vol 12548. Springer
A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial
Creators: name: Wiltink, Lisette M.
name: Marijnen, Corrie A. M.
name: Kranenbarg, Elma Meershoek-Klein
name: Velde, Cornelis J. H. Van De
name: Nout, Remi A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Background: Total mesorectal excision (TME) combined with preoperative short-term radiotherapy (PRT) reduces local recurrence rates in rectal cancer treatment. However, treatment with radiotherapy increased morbidity and did not result in a longer survival. The aim of this analysis is to provide a comprehensive longitudinal overview of the health-related quality of life (HRQL) and symptoms experienced by rectal cancer patients in the Dutch randomized TME trial from baseline until 14 years after treatment. Methods: Rectal cancer patients (n =1530) were randomly allocated to PRT (5 × 5 Gy) followed by TME or to TME alone. At baseline, 3, 6, 12, 18, and 24 months, 5 years and 14 years after treatment HRQL was evaluated in surviving patients (n =606, at 14 years after treatment). Results: None of the general symptoms differed significantly between PRT + TME and TME. However, in both treatment arms the general symptoms were increased at the diagnosis of rectal cancer, after surgery and by aging. With PRT + TME bowel symptoms were increased, specifically more fecal incontinence was reported at all time points, resulting in more use of pads for fecal incontinence (PRT + TME vs. TME at 5 years 51.5% vs. 30.5%, respectively, and at 14 years 56.4% vs. 37.1%, respectively). Conclusions: This longitudinal analysis shows that general symptoms in both groups are increased at the diagnosis of rectal cancer, after surgery and by aging, but not by RT. However, irradiated patients reported more bowel dysfunction at all time points.
title: City of Las Vegas municipal court house arrest program evaluation
Creators: name: Coyne, Karen
name: Hornstein, Michele
name: Shattler, Timothy
Publisher: name: University of Nevada, Las Vegas
Year: 2007

description: The City of Las Vegas operates a municipal detention facility, primarily housing offenders who have committed misdemeanor crimes within the 130 square miles of the Las Vegas City limits. Similar to many jurisdictions, within the State of Nevada, but also across the Country, the offender population is on the rise. The City's inmate population has grown steadily at a rate of 10%, annually, for five years. This trend, when calculated as a future projection, suggests the City must be prepared for the misdemeanant population to swell from its current daily average of 1144 to more than 3000 inmates by the year 2020. With the facility already near capacity, the expenditure of significant capital funds is inevitable, as the organization prepares for this anticipated growth and strives to ensure the conditions of confinement remain legally acceptable.
A comprehensive longitudinal overview of health-related quality of life and symptoms after treatment for rectal cancer in the TME trial
Creators: name: Wiltink, Lisette M.
name: Marijnen, Corrie A. M.
name: Kranenbarg, Elma Meershoek-Klein
name: Velde, Cornelis J. H. Van De
name: Nout, Remi A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Background: Total mesorectal excision (TME) combined with preoperative short-term radiotherapy (PRT) reduces local recurrence rates in rectal cancer treatment. However, treatment with radiotherapy increased morbidity and did not result in a longer survival. The aim of this analysis is to provide a comprehensive longitudinal overview of the health-related quality of life (HRQL) and symptoms experienced by rectal cancer patients in the Dutch randomized TME trial from baseline until 14 years after treatment. Methods: Rectal cancer patients (n =1530) were randomly allocated to PRT (5 × 5 Gy) followed by TME or to TME alone. At baseline, 3, 6, 12, 18, and 24 months, 5 years and 14 years after treatment HRQL was evaluated in surviving patients (n =606, at 14 years after treatment). Results: None of the general symptoms differed significantly between PRT + TME and TME. However, in both treatment arms the general symptoms were increased at the diagnosis of rectal cancer, after surgery and by aging. With PRT + TME bowel symptoms were increased, specifically more fecal incontinence was reported at all time points, resulting in more use of pads for fecal incontinence (PRT + TME vs. TME at 5 years 51.5% vs. 30.5%, respectively, and at 14 years 56.4% vs. 37.1%, respectively). Conclusions: This longitudinal analysis shows that general symptoms in both groups are increased at the diagnosis of rectal cancer, after surgery and by aging, but not by RT. However, irradiated patients reported more bowel dysfunction at all time points.
An evaluation of the predictive validity of the URICA and ANSOCQ scales for weight gain in adults with AN in an outpatient eating disorders program: a prospective cohort study
Creators: name: Green, Jessica
name: Phillipou, Andrea
name: Castle, David
name: Cistullo, Leonardo
name: Newton, Richard
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 320221
subject: Psychiatry (incl. psychotherapy)

description: Background: The Transtheoretical Model (TTM) which focuses on stage of change has been the main conceptual model used in understanding the lack of motivation to change in patients with Anorexia Nervosa (AN). Whilst there is evidence to support the prognostic value of the TTM in AN, this evidence base sufferers from limitations including limited studies in adults and none in outpatient populations. The primary aim of this study was to clarify whether readiness to change, as measured by the University Rhode Island Change Assessment Scale (URICA) and the Anorexia Nervosa Stages of Change Questionnaire (ANSOCQ) could predict weight gain in adults with AN following treatment in an outpatient setting. Methods: This was a prospective cohort analysis, which selectively used data from an existing clinical database at an outpatient eating disorders service. 119 patients met eligibility criteria and were included in this study. This included all adult patients who had a diagnosis of AN and were assessed, but not necessarily treated at the outpatient eating disorders program (Group 1). A subgroup of 63 patients (Group 2) was also analysed which only included patients who had received treatment at the program. Baseline measures included the URICA score, the ANSOCQ score, the Eating Disorders Examination Questionnaire (EDE-Q) and body mass index (BMI). BMI was also measured on discharge. Results: The URICA scale had poor predictive validity for weight gain (r = 0.05, p = 0.725). The ANSOCQ had moderate predictive validity (Pearson's r = 0.57, p = 0.007), and accounted for 32.7% of variance in weight gain. The URICA and ANSOCQ were moderately correlated in both groups. The URICA was moderately predictive of symptom severity, measured by the EDE-Q in both groups. The ANSOCQ was moderately correlated with the EDE-Q scores in both Groups 1 and 2. Conclusions: To the authors' knowledge this is the only study evaluating stage of change, in an adult outpatient population with AN. The findings of this study suggest that while both the URICA and ANSOCQ were associated with eating disorder symptom severity, only the ANSOCQ was able to predict weight gain in outpatients with AN suggesting its greater utility in this context.
Atlas Cartographique des habitats en milieu lagunaire méditerranéen. Période 2016-2021
Creators: name: Ouisse, Vincent
name: Miramont, Arthur
name: Bajjouk, Touria
name: Cimiterra, Nicolas
name: Derolez, Valerie
name: Fontes, Hugo
name: Giraud, Anais
name: Vaz, Sandrine
Publisher: name: Ifremer
Year: 2023

description: Cet atlas cartographique (partie 3 - projet CHAMILA) s’accompagne de 15 fiches décrivant les caractéristiques des principaux habitats (partie 2 - projet CHAMILA), et d’un guide reprenant le contexte, les méthodes utilisées pour définir les habitats ainsi qu’une analyse des données de distribution de ces habitats (partie 1 - projet CHAMILA).
The preparedness of newly qualified doctors – Views of Foundation doctors and supervisors
Creators: name: Kellett, Joanne
name: Papageorgiou, Alexia
name: Cavenagh, Penny
name: Salter, Charlotte
name: Miles, Susan
name: Leinster, Sam J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Medicine

description: Background: There is evidence that newly qualified doctors do not feel prepared to start work.Aim: This study examined the views of first year Foundation doctors (F1) and supervisors regarding how prepared they felt newly qualified doctors were for the early weeks of work.Methods: Fifty-two F1s took part in a focus group or individual interview during their first year of Foundation training. Twenty-two supervisors took part in an individual interview.Results: The F1s struggled with new responsibilities, decision-making, time management, prioritizing tasks and the large administrative component to their role. They felt unprepared for making diagnoses, prescribing and acting in an emergency. Supervisors felt F1s were generally well prepared to start work, with skills improving through experience. However, F1s needed more practical experience with real patients and more opportunities to take responsibility, make decisions and perform some clinical skills. Supervisors did not feel that F1s accessed senior support appropriately. F1s indicated they preferred to go to peers for assistance in the first instance, and felt unsupported by seniors, particularly at weekends and on night shifts.Conclusions: Specific areas of unpreparedness were identified by both F1s and supervisors; leading to recommendations to enhance effective transition from medical student to F1.
Host cell environments and antibiotic efficacy in tuberculosis
Creators: name: Day, Nathan J
name: Santucci, Pierre
name: Gutierrez, Maximiliano G
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Infectious Disease
subject: Infectious Disease
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Model organisms
subject: Model organisms

description: The aetiologic agent of tuberculosis (TB), Mycobacterium tuberculosis (Mtb), can survive, persist, and proliferate in a variety of heterogeneous subcellular compartments. Therefore, TB chemotherapy requires antibiotics crossing multiple biological membranes to reach distinct subcellular compartments and target these bacterial populations. These compartments are also dynamic, and our understanding
of intracellular pharmacokinetics (PK) often represents a challenge for antitubercular drug development. In recent years, the development of high-resolution imaging approaches in the context of host–pathogen interactions has revealed the intracellular distribution of antibiotics at a new level, yielding discoveries with important clinical implications. In this review, we describe the current knowledge regarding cellular PK of antibiotics and the complexity of drug distribution within the context of TB. We also discuss the recent advances in quantitative imaging
and highlight their applications for drug development in the context of how intracellular environments and microbial localisation affect TB treatment efficacy.
Construction sector views on low carbon building materials
Creators: name: Giesekam, Jannik
name: Barrett, John R.
name: Taylor, Peter
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: As is the case in a number of countries, the UK construction industry faces the challenge of expanding production whilst making ambitious greenhouse gas emission reductions. Embodied carbon constitutes a growing proportion of whole-life carbon emissions and accounts for a significant share of total UK emissions. A key mitigation strategy is increasing the use of alternative materials with lower embodied carbon. The economic, technical, practical and cultural barriers to the uptake of these alternatives are explored through a survey of construction professionals and interviews with industry leaders. Perceptions of high cost, ineffective allocation of responsibility, industry culture, and the poor availability of product and building-level carbon data and benchmarks constitute significant barriers. Opportunities to overcome these barriers include earlier engagement of professionals along the supply chain, effective use of whole-life costing, and changes to contract and tender documents. A mounting business case exists for addressing embodied carbon, but has yet to be effectively disseminated. In the meantime, the moral convictions of individual clients and practitioners have driven early progress. However, this research underscores the need for new regulatory drivers to complement changing attitudes if embodied carbon is to be established as a mainstream construction industry concern.