cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107
Creators: name: Tomberlin, Ginger H.
name: Mei, Yingwu
name: Townsend, Claire
name: Kramer, Henning H.
name: Meissner, Gerhard
name: Xu, Le
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Activation of the skeletal muscle ryanodine receptor (RyR1) complex results in the rapid release of Ca2+ from the sarcoplasmic reticulum and muscle contraction. Dissociation of the small FK506 binding protein 12 subunit (FKBP12) increases RyR1 activity and impairs muscle function. The 1,4-benzothiazepine derivative JTV519, and the more specific derivative S107 (2,3,4,5,-tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine), are thought to improve skeletal muscle function by stabilizing the RyR1-FKBP12 complex. Here, we report a high degree of nonspecific and specific low affinity [3H]S107 binding to SR vesicles. SR vesicles enriched in RyR1 bound ∼48 [3H]S107 per RyR1 tetramer with EC50 ∼52 µM and Hillslope ∼2. The effects of S107 and FKBP12 on RyR1 were examined under conditions that altered the redox state of RyR1. S107 increased FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. Addition of 0.15 µM FKBP12 to SR vesicles prevented FKBP12 dissociation; however, in the presence of oxidized glutathione and NOC12, FKBP12 dissociation was observed in skeletal muscle homogenates that contained 0.43 µM myoplasmic FKBP12 and was attenuated by S107. In single channel measurements with FKBP12-depleted RyR1s, in the absence and presence of NOC12, S107 augmented the FKBP12-mediated decrease in channel activity. The data suggest that S107 can reverse the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites.
THE FIELDS OF FASHION PROJECT: A CASE FOR INTELLECTUAL BRICOLAGE AND A GEOGRAPHY OF (RURAL) FASHION
Creators: name: Goodrum, Alison
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: This research paper was presented at Futurescan: Mapping the Territory, Foresight Centre, University of Liverpool, 17-18 November 2009.

Futurescan: Mapping the Territory
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
Enumeration of m-Endomorphisms
Creators: name: Rubin, Louis
name: Rushton, Brian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 05A99 (Primary), 20M15 (Secondary)

description: An m-endomorphism of a free semigroup is an endomorphism that sends every generator to a word of length at most m. Two m-endomorphisms are combinatorially equivalent if they are conjugate under an automorphism of the semigroup. In this paper, we specialize an argument of N. G. de Bruijn to produce a formula for the number of combinatorial equivalence classes of m-endomorphisms on a rank-n semigroup. From this formula, we derive several little-known integer sequences.
description: To appear in Involve: A Journal of Mathematics
A Bespoke Instrumental Variable Approach to Correction for Exposure Measurement Error
Creators: name: Cole, S.R.
name: Keil, A.P.
name: Richardson, D.B.
name: Edwards, J.K.
name: Tchetgen Tchetgen, E.J.
Publisher: name: NLM (Medline)
Year: 2022

description: A covariate-adjusted estimate of an exposure-outcome association may be biased if the exposure variable suffers measurement error. We propose an approach to correct for exposure measurement error in a covariate-adjusted estimate of the association between a continuous exposure variable and outcome of interest. Our proposed approach requires data for a reference population in which the exposure was a priori set to some known level (e.g., 0, and is therefore unexposed); however, our approach does not require an exposure validation study or replicate measures of exposure, which are typically needed when addressing bias due to exposure measurement error. A key condition for this method, which we refer to as "partial population exchangeability," requires that the association between a measured covariate and outcome in the reference population equals the association between that covariate and outcome in the target population in the absence of exposure. We illustrate the approach using simulations and an example.
Partial linear inference for a 2-stage outcome-dependent sampling design with a continuous outcome
Creators: name: Qin, Guoyou
name: Zhou, Haibo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The outcome-dependent sampling (ODS) design, which allows observation of exposure variable to depend on the outcome, has been shown to be cost efficient. In this article, we propose a new statistical inference method, an estimated penalized likelihood method, for a partial linear model in the setting of a 2-stage ODS with a continuous outcome. We develop the asymptotic properties and conduct simulation studies to demonstrate the performance of the proposed estimator. A real environmental study data set is used to illustrate the proposed method.
'IT LOOKS VERY HOME DRESS-MAKEY' STRATEGIES TO ENCOURAGE FASHION DESIGN STUDENTS TO REAUSE A PROFESSIONALLY FINISHED GARMENT: CUT, CONSTRUCTION, FABRIC, COLOUR
Creators: name: Almond, Kevin
Publisher: name: FUTURESCAN
Year: 2019
Subjects: subject: 120306 Textile and Fashion Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: 'This research paper was presented at Futurescan: Mapping the Territory, Foresight Centre, University of Liverpool, 17-18 November 2009.
Futurescan: Mapping the Territory
Edited by Sally Wade and Kerry WaltonFebruary 2011ISBN: 978 1 907382 30 7
Additional file 7 of Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample
Creators: name: Ma, Canchen
name: Aitken, Dawn
name: Wu, Feitong
name: Squibb, Kathryn
name: Cicuttini, Flavia
name: Jones, Graeme
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 7: Supplementary Table 6. Standardized beta-coefficients for the associations of osteophyte and joint space narrowing scores at hand joints with HRpQCT measures (per SD) at distal radius (N=201).
Longitudinal HIV care outcomes by gender identity in the United States
Creators: name: Poteat, T.C.
name: Crane, H.M.
name: Moore, R.D.
name: Althoff, K.N.
name: Rich, A.J.
name: Buchacz, K.
name: McGinnis, K.A.
name: Rebeiro, P.F.
name: Horberg, M.
name: Edwards, J.K.
name: Silverberg, M.J.
name: Hanna, D.B.
name: Mayor, A.M.
name: Rabkin, C.S.
name: Lesko, C.R.
Publisher: name: Lippincott Williams and Wilkins
Year: 2022

description: Objective: Describe engagement in HIV care over time after initial engagement in HIV care, by gender identity.Design:Observational, clinical cohort study of people with HIV engaged in routine HIV care across the United States. Methods: We followed people with HIV who linked to and engaged in clinical care (attending ≥2 visits in 12 months) in cohorts in the North American Transgender Cohort Collaboration, 2000-2018. Within strata of gender identity, we estimated the 7-year (84-month) restricted mean time spent: lost-to-clinic (stratified by pre/postantiretroviral therapy (ART) initiation); in care prior to ART initiation; on ART but not virally suppressed; virally suppressed (≤200 copies/ml); or dead (pre/post-ART initiation). Results: Transgender women (N = 482/101 841) spent an average of 35.5 out of 84 months virally suppressed (this was 30.5 months for cisgender women and 34.4 months for cisgender men). After adjustment for age, race, ethnicity, history of injection drug use, cohort, and calendar year, transgender women were significantly less likely to die than cisgender people. Cisgender women spent more time in care not yet on ART, and less time on ART and virally suppressed, but were less likely to die compared with cisgender men. Other differences were not clinically meaningful. Conclusions: In this sample, transgender women and cisgender people spent similar amounts of time in care and virally suppressed. Additional efforts to improve retention in care and viral suppression are needed for all people with HIV, regardless of gender identity.
title: Auf dem Weg zu sozial-ökologischen Transformationen?: Policy-Orientierungen der Landesparteien während der Popularisierung der Klimakrise im Jahr 2019
Creators: name: Gimper, Kevin
Publisher: name: Friedrich-Schiller-Universität Jena
Year: 2020
Subjects: subject: Brandburg
subject: Bremen
subject: Thüringen
subject: Wahlprogramm
subject: Inhaltsanalyse
subject: Politikfeldanalyse
subject: Partei
subject: Klimaänderung
subject: Umweltpolitik
subject: Klimaschutz
subject: Politische Beteiligung
subject: Deutsche Geschichte des 19. Jahrhunderts bis zur Gegenwart
subject: 320
subject: 300

description: Nicht nur die Klimawissenschaft ist sich bereits seit Jahrzehnten einig, dass der anthropogene Klimawandel mit seinen Folgen eine ernstzunehmende Bedrohung für die Menschen und ihre Mit- bzw. Umwelt darstellt. Dennoch haben es die menschlichen Gesellschaften als Ganze bisher nicht geschafft, ein Umsteuern zur Vermeidung der schlimmsten Auswirkungen der Klimakrise nachhaltig anzugehen. Diese politikwissenschaftliche Masterarbeit geht daher der Frage nach, inwiefern die Popularisierung der Klimakrise in bzw. seit dem Jahr 2019 hinsichtlich der gesellschaftlichen Mobilisierungen sowie sozial-ökologischen Herausforderungen für responsive Veränderungen in den politischen Systemen sorgte. Als Fälle werden die Bundesländer Bremen, Brandenburg und Thüringen betrachtet, in denen 2019 jeweils Landtagswahlen stattfanden. Im Fokus der Analyse stehen dabei die Policy-Entwicklungen in den Wahlprogrammen der relevanten Landesparteien. Sie werden vor dem Hintergrund des Konzepts der sozial-ökologischen Transformation - hier ausgehend vom soziologischen Rahmenkonzept gesellschaftlicher Naturverhältnisse definiert - inhaltsanalytisch untersucht.
On canonically polarized Gorenstein 3-folds satisfying the Noether equality
Creators: name: Chen, Yifan
name: Hu, Yong
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We study canonically polarized Gorenstein $3$-folds with at most terminal singularities and satisfying $K_X^3=\frac 43p_g(X)-\frac {10}3$ and $p_g(X) \ge 7$. We characterize the canonical maps of such $3$-folds, describe a structure theorem for the locally factorial ones and completely classify the smooth ones. New examples of canonically polarized smooth $3$-folds with $K_X^3=\frac 43p_g(X)-\frac {10}3$ and $p_g(X) \ge 7$ are constructed. These examples are natural extensions of those constructed by M.~Kobayashi.
description: Revised version, 17 pages
Wandesia vermiformis Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Protziidae
Wandesia
Wandesia vermiformis

description: Wandesia vermiformis Cook, 1967
Records from the study area: Maharashtra, Tamil Nadu—Cook (1967); Prasad (1974); Pešić & Ranga Reddy (2009).
Habitat: Hyporheic interstitial.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 8, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Xylazine Update at Wake County Drug Overdose Prevention Coalition Meeting
Creators: name: Dasgupta, Nabarun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023
Subjects: Drugs
Drugs--Overdose
Public health
Drug traffic

description: Update on North Carolina street drug supply and xylazine. Presented to Wake County Drug Overdose Prevention Coalition Meeting on opioid settlements.
A descriptive exploration of younger and older adults’ experiences of Integrative Medical Group Visits for Long COVID
Creators: name: Okanlawon Bankole A.
name: Barnhill J.
name: Mata R.
name: Roth I.
Publisher: name: Elsevier B.V.
Year: 2023

description: Introduction: Long COVID disproportionately affects older adults. Individuals with Long COVID (LC) often experience symptoms that severely impact quality of life, and treatment approaches are still evolving. The Integrative Medical Group Visit (IMGV) model is an evidence-based approach that may be useful to treat patients with LC; however, there is limited evidence describing the experience and/or feasibility of using IMGV for LC treatment, especially among the older adult population. The purpose of this study is to describe older and younger adults’ experiences of both having LC and participating in a virtually delivered IMGV for LC. Methods: This is a secondary analysis of qualitative data from a parent study examining the experiences of participants in a virtually delivered IMGV for patients with LC. Patients participated in semi-structured interviews before and after 8 weekly IMGV sessions. Thematic analysis was used to analyze interview data. Results: Overall, 21 pre-interviews and 17 post-interviews were collected. Thematic analysis of patient interviews by age group resulted in three themes that each contained similarities and differences between the younger and older adult participants. These themes included: (1) experiences of LC (2) feelings about the future (3) experiences of the pilot IMGV on LC. Conclusion: This study provides critical context for clinicians who treat older adults with LC. Results support virtually delivered IMGVs as a potentially feasible option for both older and younger adults who want to apply an integrative approach to their LC treatment. Findings from this study will inform future research on IMGV for LC treatment.
Asymptotic analysis of symmetric functions
Creators: name: Götze, Friedrich
name: Naumov, Alexey
name: Ulyanov, Vladimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: In this paper we consider asymptotic expansions for a class of sequences of symmetric functions of many variables. Applications to classical and free probability theory are discussed.
description: 17 pages, accepted, to appear in Journal of Theoretical Probability
Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine
Creators: name: Cleven, Thomas
name: Baric, Ralph
name: Yamamoto, Shinya
name: Uraki, Ryuta
name: Kumar, Sathish
name: Suresh, M.
name: Yotsuyanagi, Hiroshi
name: Koga, Michiko
name: Yount Jr, Boyd L.
name: Mishra, Jay S.
name: Kawaoka, Yoshihiro
name: Iwatsuki-Horimoto, Kiyoko
name: Park, Hongtae
name: Bussan, Hailey
name: Kingstad-Bakke, Brock
name: Halfmann, Peter J.
Publisher: name: American Society for Clinical Investigation
Year: 2023

description: Although SARS-CoV-2 evolution seeds a continuous stream of antibody-evasive viral variants, COVID-19 mRNA vaccines provide robust protection against severe disease and hospitalization. Here, we asked whether mRNA vaccine-induced memory T cells limits lung SARS-CoV-2 replication and severe disease. We show that mice and humans receiving booster BioNTech mRNA vaccine developed potent CD8 T-cell responses and show similar kinetics of expansion and contraction of granzyme B/perforin-expressing effector CD8 T cells. Both monovalent and bivalent mRNA vaccines elicited strong expansion of a heterogeneous pool of terminal effectors and memory precursor effector CD8 T cells in spleen, inguinal and mediastinal lymph nodes, pulmonary vasculature, and most surprisingly in the airways, suggestive of systemic and regional surveillance. Further, we document that: (1) CD8 T-cell memory persists in multiple tissues for >200 days; (2) following challenge with pathogenic SARS-CoV-2, circulating memory CD8 T cells rapidly extravasate to the lungs and promote expeditious viral clearance, by mechanisms that require CD4 T cell help; (3) adoptively transferred splenic memory CD8 T cells traffic to the airways, and promote lung SARS-CoV-2 clearance. These findings provide new insights into the critical role of memory T cells in preventing severe lung disease following breakthrough infections with antibody-evasive SARS-CoV-2 variants.
Encrypted VPN Dataset
Creators: name: Naas, Mohamed
name: Fesl, Jan
Publisher: name: Zenodo
Year: 2022
Subjects: Machine Learning, IP flow, IPFIX, Network Traffic, SSTP, OpenVPN, WireGuard

description: Encryption of network traffic should guarantee anonymity and prevent potential interception of information. Encrypted virtual private networks (VPNs) are designed to create special data tunnels that allow reliable transmission between networks and/or end users. However, as has been shown in a number of scientific papers, encryption alone may not be sufficient to secure data transmissions in the sense that certain information may be exposed. Our team has constructed a large dataset that contains generated encrypted network traffic data. This dataset contains a general network traffic model consisting of different types of network traffic such as web, emailing, video conferencing, video streaming, and terminal services. For the same network traffic model, data are measured for different scenarios, i.e., for data traffic through different types of VPNs and without VPNs. Additionally, the dataset contains the initial handshake of the VPN connections. The dataset can be used by various data scientists dealing with the classification of encrypted network traffic and encrypted VPNs.
“Caregiving Youth” and the Patchwork History of Recognition in the United States
Creators: name: Olson, Elizabeth
name: Edmonds, Leiha
Publisher: name: MDPI
Year: 2023

description: This article examines the U.S. legislative and policy landscape and its historical and contemporary recognition of young people as caregivers and their importance to public health, both as care providers and as a category of special concern for overall wellbeing. Drawing on feminist geographies of health to situate a historical analysis, we aim to answer two key questions: First, what is the history of recognition of caregiving youth in key moments of federal action to address family caregiving needs? Second, how might we use this history to better understand and analyze the patchwork geography of caregiving youth recognition in the U.S. and other countries that similarly lack formal national policy recognition to improve and enhance public health? We use the term patchwork to describe how federal recognition of caregiving youth in broader debates about public health is uneven across both time and space, and contingent upon civil society, non-profit organizations, and researchers working in and with geographically bound communities. Our results illustrate how a focus on the relationships of recognition, both in the past and the present and at local and national scales, reveals a different perspective on caregiving youth in the U.S. with a much more complex history than previously identified. The article describes how relationships established in the absence of federal policy or legislation are sometimes directed towards building more formal recognition, and other times with the goal of changing practices in a specific location.
title: Entwicklung eines Compilers für eine auf Cg basierende Sprache zur Programmierung von Grafikkarten
Creators: name: Richter, Frank
Publisher: name: Friedrich-Schiller-Universität Jena
Year: 2011
Subjects: subject: C for graphics
subject: Grafik
subject: Programmiersprache
subject: Shader
subject: Compiler
subject: Dimension
subject: Cg
subject: 3D
subject: 004

description: In dieser Arbeit wurde eine Sprache zur Programmierung von Grafikprozessoren sowie ein diese Sprache übersetzender Compiler entwickelt. Schwerpunkt ist die Besonderheit des Compiler, mehrerer Ausgabeprogramme aus einem Eingabeprogramm zu erzeugen. Die verschiedenen Ausgabeprogramme zielen dabei auf verschiedene Funktionseinheiten eines Grafikprozessors ab. Die Aufspaltung in die Ausgabeprogramme wird so vorgenommen, das im Zusammenspiel der verschiedenen Programme auf den verschiedenen Funktionseinheiten die Semantik des Eingabeprogramms umgesetzt wird. Für die Aufspaltung selbst wurden Kriterien entworfen, die den speziellen Aufbau und Datenfluss auf Grafikprozessoren berücksichtigen und ausnutzen. Die entwickelte Programmiersprache ist eine Hochsprache, die in wesentlichen Zügen auf der Sprache Cg basiert, im Vergleich aber signifikant vereinfacht wurde und in der syntaktisch bewusste einige eigene Wege eingeschlagen wurden.
Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1
Creators: name: Schuettrumpf, Joerg
name: Lotfi, Yasmin
name: Mingozzi, Federico
name: Xiao, Weidong
name: Arruda, Valder R.
name: Nichols, Timothy C.
name: Couto, Linda B.
name: High, Katherine A.
name: Herzog, Roland W.
name: Robinson, Nancy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Adeno-associated viral (AAV) vectors (serotype 2) efficiently transduce skeletal muscle, and have been used as gene delivery vehicles for hemophilia B and for muscular dystrophies in experimental animals and humans. Recent reports suggest that AAV vectors based on serotypes 1, 5, and 7 transduce murine skeletal muscle much more efficiently than AAV-2, with reported increases in expression ranging from 2-fold to 1000-fold. We sought to determine whether this increased efficacy could be observed in species other than mice. In immunodeficient mice we saw 10- to 20-fold higher levels of human factor IX (hF.IX) expression at a range of doses, and in hemophilic dogs we observed approximately 50-fold higher levels of expression. The increase in transgene expression was due partly to higher gene copy number and a larger number of cells transduced at each injection site. In all immunocompetent animals injected withAAV-1, inhibitory antibodies to F.IX developed, but in immunocompetent mice treated with high doses of vector, inhibitory antibodies eventually disappeared. These studies emphasize that the increased efficacy of AAV-1 vectors carries a risk of inhibitor formation, and that further studies will be required to define doses and treatment regimens that result in tolerance rather than immunity to F.IX.
Deformations of polarized automorphic Galois representations and adjoint Selmer groups
Creators: name: Allen, Patrick B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11F80, 11R34, 11F70

description: We prove the vanishing of the geometric Bloch-Kato Selmer group for the adjoint representation of a Galois representation associated to regular algebraic polarized cuspidal automorphic representations under an assumption on the residual image. Using this, we deduce that the localization and completion of a certain universal deformation ring for the residual representation at the characteristic zero point induced from the automorphic representation is formally smooth of the correct dimension. We do this by employing the Taylor-Wiles-Kisin patching method together with Kisin's technique of analyzing the generic fibre of universal deformation rings. Along the way we give a characterization of smooth closed points on the generic fibre of Kisin's potentially semistable local deformation rings in terms of their Weil-Deligne representations.
description: Added reference to work of Breuil-Hellmann-Schraen. Minor change in assumption (b) of Theorems C and 3.1.3. Added Theorem 3.2.3 and subsection 3.3. Corrected typos and incorporated suggestions of the referee. To appear in Duke Math. J
title: Processes and patterns of classroom life
title: the dynamics of exchanging knowledge and values between teachers and learners in English language writing classrooms
titleType: Subtitle
Creators: name: Scott, Andrew
Publisher: name: Lancaster University
Year: 2023
Subjects: Education
Curriculum enactment
Classroom discourse
Writing
Teacher feedback
Feedback practices
Teaching choices
Pedagogic aims
Pedagogic tool
Legitimation Code Theory
Systemic functional linguistics
Pedagogic register analysis
Teaching and learning

description: Classrooms are complex. This complexity emerges from the social practices and language uses that have developed in education. This thesis furthers our understanding of teacher feedback practices in pre-tertiary academic English writing classrooms. I examine curriculum enactment in context from three perspectives: that of classroom interactions between teacher and learners; feedback practices across four different classrooms; and the spheres of control of curriculum agents. Studies on teacher feedback in the Second Language Acquisition and TESOL literature have researched types of reified feedback and identified their importance in language development (Ellis, 2009). However, fewer studies have examined how teacher written feedback is incorporated into classroom discourse, an essential part of curriculum enactment and the achievement of lesson objectives. The study uses a synthesis of explanatory frameworks from Legitimation Code Theory (Maton, 2014) and pedagogic register analysis from the Martinian model of systemic functional linguistics (Martin, 1992; Martin & Rose, 2007; Rose, 2014; 2018; 2020) to analyse the knowledge and language of teacher feedback practices. The study draws four main conclusions. Firstly, agent alignment is essential to understanding curriculum enactment. Secondly, teachers use feedback to meet course objectives while also meeting learners’ needs, two targets that are not always in alignment. Thirdly, the study identifies semiotic resources employed in teacher feedback practices and establishes how these link to teaching choices in the classroom. Finally, the study suggests how to move the field beyond its current limits, namely the dichotomy of the written corrective feedback debate (Truscott, 1996; 1999, Ferris, 1999; 2004) and the limitations of cause-and-effect studies that attempt to identify the most effective forms of feedback (Bitchener & Ferris, 2012). I recommend a model that conceptualizes feedback as a pedagogic tool used dynamically by experienced teachers to oscillate between interpretation and evaluation, from sense making to meaning making, in classroom activities.
Additional file 1 of Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study
Creators: name: Iglesias-Vázquez, Lucía
name: Hernández-Martínez, Carmen
name: Voltas, Núria
name: Canals, Josefa
name: Coronel, Pilar
name: Gimeno, Mercedes
name: Arija, Victoria
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 1. Supplementary Table 1. Maternal characteristics of participants included and non-included in theanalyses.
Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells
Creators: name: Haberichter, Sandra L.
name: Montgomery, Robert R.
name: Nichols, Timothy C.
name: Fahs, Scot A.
name: Christopherson, Pamela A.
name: Merricks, Elizabeth P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Type 3 von Willebrand disease (VWD) is a severe hemorrhagic defect in humans. We now identify the homozygous mutation in the Chapel Hill strain of canine type 3 VWD that results in premature termination of von Willebrand factor (VWF) protein synthesis. We cultured endothelium from VWD and normal dogs to study intracellular VWF trafficking and Weibel-Palade body formation. Weibel-Palade bodies could not be identified in the canine VWD aortic endothelial cells (VWD-AECs) by P-selectin, VWFpp, or VWF immunostaining and confocal microscopy. We demonstrate the reestablishment of Weibel-Palade bodies that recruit endogenous P-selectin by expressing wild-type VWF in VWD-AECs. Expression of mutant VWF proteins confirmed that VWF multimerization is not necessary for Weibel-Palade body creation. Although the VWF propeptide is required for the formation of Weibel-Palade bodies, it cannot independently induce the formation of the granule. These VWF-null endothelial cells provide a unique opportunity to examine the biogenesis of Weibel-Palade bodies in endothelium from a canine model of type 3 VWD.
An open-source probabilistic record linkage process for records with family-level information: Simulation study and applied analysis
Creators: name: Prindle J.
name: Putnam-Hornstein E.
name: Suthar H.
Publisher: name: Public Library of Science
Year: 2023

description: Research with administrative records involves the challenge of limited information in any single data source to answer policy-related questions. Record linkage provides researchers with a tool to supplement administrative datasets with other information about the same people when identified in separate sources as matched pairs. Several solutions are available for undertaking record linkage, producing linkage keys for merging data sources for positively matched pairs of records. In the current manuscript, we demonstrate a new application of the Python RecordLinkage package to family-based record linkages with machine learning algorithms for probability scoring, which we call probabilistic record linkage for families (PRLF). First, a simulation of administrative records identifies PRLF accuracy with variations in match and data degradation percentages. Accuracy is largely influenced by degradation (e.g., missing data fields, mismatched values) compared to the percentage of simulated matches. Second, an application of data linkage is presented to compare regression model estimate performance across three record linkage solutions (PRLF, ChoiceMaker, and Link Plus). Our findings indicate that all three solutions, when optimized, provide similar results for researchers. Strengths of our process, such as the use of ensemble methods, to improve match accuracy are discussed. We then identify caveats of record linkage in the context of administrative data.
Assessing the Impacts of Energy Communities: An Overview of (Potential) Costs and Benefits
Creators: name: Holstenkamp, Lars
name: Kriel, Christian
Publisher: name: Zenodo
Year: 2022
Subjects: Model Assessment Template
Energy Communities
Benefits
Social Acceptance
Effectiveness
Emancipation
Legitimacy

description: According to the recast Renewable Energy Directive (RED II), member states (MS) of the European Union (EU) are supposed to take out assessments of barriers for and potential of renewable energy communities in their countries (RED II, Art. 22 Para. 3). The European legislator has not specified this provision, i.e. the content and form of these assessments has not been clarified (yet). It is only clear from the legal text that these assessments should be the basis of the “enabling framework” (RED II, Art. 22 Para. 4) that EU MS shall provide. The project aims at developing a template for the assessments. In the paper, we briefly review existing studies on impacts of energy communities, based on the Berka & Creamer (2018) study. We group potential costs and benefits into three categories: effectiveness, emancipation and legitimacy, respectively. We add literature and known effects from references in Berka & Creamer (2018) plus some selected additional works. This background paper is part of a study on a model assessment of potential and barriers to the development of renewable energy communities at the national level, commissioned by REScoop.eu.
title: Computer-assisted approaches to historical language comparison
Creators: name: List, Johann-Mattis
Publisher: name: Friedrich-Schiller-Universität Jena
Year: 2021
Subjects: subject: Mathematische Linguistik
subject: 400

description: The proposal of new quantitative methods supposed to handle problems in historical linguistics has created a gap between what one could call “classical” approaches to historical language comparison and the “new and innovative” automatic approaches. Classical linguists are often skeptical of the new approaches, partly because the results differ from those achieved by classical methods (Anthony and Ringe 2015, Holm 2007), but also because the majority of the new approaches work in a black box fashion and do not allow inspecting the concrete findings in detail. Computational linguists, on the other hand, complain about classical historical linguists’ lack of consistency when applying the classical methods.
Signal recognition efficiencies of artificial neural-network pulse-shape discrimination in HPGe $0νββ$-decay searches
Creators: name: Caldwell, A.
name: Cossavella, F.
name: Majorovits, B.
name: Palioselitis, D.
name: Volynets, O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: A pulse-shape discrimination method based on artificial neural networks was applied to pulses simulated for different background, signal and signal-like interactions inside a germanium detector. The simulated pulses were used to investigate variations of efficiencies as a function of used training set. It is verified that neural networks are well-suited to identify background pulses in true-coaxial high-purity germanium detectors. The systematic uncertainty on the signal recognition efficiency derived using signal-like evaluation samples from calibration measurements is estimated to be 5\%. This uncertainty is due to differences between signal and calibration samples.
Polyclonal Antibody Optimization
Creators: name: Janet Smith
Publisher: name: Zenodo
Year: 2024

description: CD ComputaBio offers a comprehensive range of services designed to optimize polyclonal antibodies for a variety of applications. Our team of experienced scientists and bioinformaticians utilize state-of-the-art computational algorithms and advanced technologies to improve antibody specificity, affinity, and selectivity, ultimately enhancing antibody performance in a range of research and diagnostic applications.
title: Studies on Some Bacteriolytic Bacteria Isolated from an Oxidation Pond
Creators: name: Radich, Paul Christian
Publisher: name: Utah State University
Year: 1973

description: During bacteriological studies of the Logan City Sewage Oxidation Ponds, Logan, Utah, a group of bacteria was discovered which could lyse killed cells of Escherichia coli. The present research effort was an attempt to determine whether two isolates from this earlier study might play a role in the reduction of coliforms and other bacteria in the oxidation ponds. It was also desired to characterize partially the lytic enzymes produced by the two isolates and to determine as far as possible the organisms' identity.
Both isolates were Gram negative rod-shaped organisms with a single polar flagellum. On Cytophaga agar they produced small, circular, yellow-pigmentecl colonies. The optimum temperature for growth of both isolates was found to be 20 C. Both isolates exhibited proteolytic activity but lacked any lipolytic ability. On the basis of these and other characteristics, the two isolates were tentatively placed in the genus Xanthomonas.
By the use of an agar overlay technique, it was shown that both isolates could lyse a wide variety of bacteria. Those genera which were lysed to the greatest extent were Citrobacter, Enterobacter, Escherichia and Salmonella. Neither of the isolates were able to lyse bacteria belonging to the genera Corynebacterium, Leuconostoc, Neisseria or Streptococcus. Generally the isolates showed greater lytic ability against Gram negative bacteria than against Gram positive bacteria.
By concentrating the growth liquor containing the lytic enzyme and testing its lytic ability, it was determined that the optimum pH for lysis of autoclaved E. coli cells for the enzyme from one isolate was approximately pH 8.0, and pH 7.5 for the other. The optimum temperature for lysis by the enzymes from both isolates was found to be 20 C.
All attempts to show lysis of live bacteria were unsuccessful. Thus the role of these two organisms in the ecology of waste treatment ponds would probably be that of a scavenger on dead or killed cells and would not affect the population of live coliforms or other bacteria.
A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan
Creators: name: Hajjo R.
name: Al-Momany A.
name: Sabbah D.A.
name: Almomani E.Y.
name: Qablan A.
Publisher: name: Frontiers Media SA
Year: 2023

description: Background: COVID-19 vaccines continue to save people’s lives around the world; however, some vaccine adverse events have been a major concern which slowed down vaccination campaigns. Anecdotal evidence pointed to the vaccine effect on menstruation but evidence from the adverse event reporting systems and the biomedical literature was lacking. This study aimed to investigate the physiological changes in women during menstruation amid the COVID-19 vaccination. Methods: A cross-sectional online survey was distributed to COVID-19 vaccinated women from Nov 2021 to Jan 2022. The results were analyzed using the SPSS software. Results: Among the 564 vaccinated women, 52% experienced significant menstrual irregularities post-vaccination compared to before regardless of the vaccine type. The kind of menstrual irregularity varied among the vaccinated women, for example, 33% had earlier menstruation, while 35% reported delayed menstruation. About 31% experienced heavier menstruation, whereas 24% had lighter menstrual flow. About 29% had menstruation last longer, but 13% had it shorter than usual. Noteworthy, the menstrual irregularities were more frequent after the second vaccine shot, and they disappeared within 3 months on average. Interestingly, 24% of the vaccinated women reported these irregularities to their gynecologist. Conclusion: The COVID-19 vaccine may cause physiological disturbances during menstruation. Luckily, these irregularities were short-termed and should not be a reason for vaccine hesitancy in women. Further studies are encouraged to unravel the COVID-19 vaccine adverse effect on women’s health.
Additional file 2 of Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study
Creators: name: Iglesias-Vázquez, Lucía
name: Hernández-Martínez, Carmen
name: Voltas, Núria
name: Canals, Josefa
name: Coronel, Pilar
name: Gimeno, Mercedes
name: Arija, Victoria
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 2. Supplementary Table 2. Maternal concentrations of iron-related biomarkers, vitamin B12, and RBC folate.
A Cost-Utility Analysis of Ablative Therapy for Barrett's Esophagus
Creators: name: Somsouk, Ma
name: Inadomi, John M.
name: Shaheen, Nicholas J.
name: Thomas, Jennifer P.
name: Madanick, Ryan D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Recommendations for patients with Barrett’s esophagus (BE) include endoscopic surveillance with esophagectomy for early-stage cancer, although new technologies to ablate dysplasia and metaplasia are available. This study compares the cost-utility of ablation with that of endoscopic surveillance strategies.
Criteria for 2D kinematics in an interacting Fermi gas
Creators: name: Dyke, P.
name: Fenech, K.
name: Peppler, T.
name: Lingham, M. G.
name: Hoinka, S.
name: Zhang, W.
name: Mulkerin, B.
name: Hu, H.
name: Liu, X. -J.
name: Vale, C. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Ultracold Fermi gases subject to tight transverse confinement offer a highly controllable setting to study the two-dimensional (2D) BCS to Berezinskii-Kosterlitz-Thouless superfluid crossover. Achieving the 2D regime requires confining particles to their transverse ground state which presents challenges in interacting systems. Here, we establish the conditions for an interacting Fermi gas to behave kinematically 2D. Transverse excitations are detected by measuring the transverse expansion rate which displays a sudden increase when the atom number exceeds a critical value $N_{2D}$ signifying a density driven departure from 2D kinematics. For weak interactions $N_{2D}$ is set by the aspect ratio of the trap. Close to a Feshbach resonance, however, the stronger interactions reduce $N_{2D}$ and excitations appear at lower density.
description: Replaced with published version, includes supplementary information
Supplementary text from Relating evolutionary selection and mutant clonal dynamics in normal epithelia
Creators: name: Hall, Michael W. J.
name: Jones, Philip H.
name: Hall, Benjamin A.
Publisher: name: Figshare
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60114 Systems Biology
subject: Computational Biology

description: Cancer develops from mutated cells in normal tissues. Whether somatic mutations alter normal cell dynamics is key to understanding cancer risk and guiding interventions to reduce it. An analysis of the first incomplete moment of size distributions of clones carrying cancer-associated mutations in normal human eyelid skin gives a good fit with neutral drift, arguing mutations do not affect cell fate. However, this suggestion conflicts with genetic evidence in the same dataset that argues for strong positive selection of a subset of mutations. This implies cells carrying these mutations have a competitive advantage over normal cells, leading to large clonal expansions within the tissue. In the normal epithelium, clone growth is constrained by the limited size of the proliferating compartment and competition with surrounding cells. We show that if these factors are taken into account, the first incomplete moment of the clone size distribution is unable to exclude non-neutral behaviour. Furthermore, experimental factors can make a non-neutral clone size distribution appear neutral. We validate these principles with a new experimental dataset showing that when experiments are appropriately designed, the first incomplete moment can be a useful indicator of non-neutral competition. Finally, we discuss the complex relationship between mutant clone sizes and genetic selection.
Validera eller försvinn!
Creators: name: Philipson, Joakim
Publisher: name: Kungliga biblioteket -National Library of Sweden
Year: 2024
Subjects: validation
XML
Schematron
RDF

description: Presentation in Swedish at internal conference, Kungliga biblioteket - National Library of Sweden, (2015, Oct. 13). On validation of xml-documents mainly (with reference also to RDF validation still in the making at that time).
Diversity of bacteria associated with lichens in Mt. Yunmeng in Beijing, China
Creators: name: LI, YIMENG
name: Huang, Yinzhi
name: Huang, Manrong
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310703
subject: Microbial ecology

description: Lichens host highly diverse and complex microbial communities, which may perform essential functions in the symbiotic ecosystems. In this study, sequencing of 16S rRNA was used to investigate the bacterial communities associated with two growth forms (foliose and crustose) of lichens. Results showed that Cyanobacteria, Pseudomonadota, Actinomycetota and Acidobacter were dominant phyla in both types of lichens, while Acetobacterales and Hyphomicrobiales were the dominant order. Alpha diversity index showed that the richness of associated bacterial community in foliose lichens was significantly higher than that in crustose ones (P<0.05), and PCoA results showed a significant difference between beta diversity of the foliose lichen-associated bacteria communities and that of crustose lichen-associated communities (P<0.05). It can be inferred that the growth form of lichens is the most important factor affecting the associated bacteria community, and the host species comes next, while altitude are even less important. It is proposed that the microbial communities play important roles in fixing nitrogen, providing nutrition, and curbing harmful microorganisms, therefore are an integrated and indispensable part of lichens, and together they form a self-sufficient ecosystem. (S9409-F1,S9410-F2,S9411-F3,S9491-F4,S9520-F5,S9521-F6,S9530-F7,S9552-F8,S9553-F9,S9570-F10; S9540-C1,S9482-C2,S9487-C3,S9505-C4,S9531-C5,S9532-C6,S9533-C7,S9541-C8,S9566-C9,S9567-C10)
Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis
Creators: name: Alvaro, D.
name: Bosco, D.
name: Bragazzi, M.C.
name: Semeraro, R.
name: Franchitto, A.
name: Gatto, M.
name: Attili, A.F.
name: Fraveto, A.
name: Carpino, G.
name: Napoli, C.
name: Gentile, R.
name: Torrice, A.
name: Gaudio, E.
name: Cardinale, V.
name: Nuti, M.
name: Bastianelli, C.
name: Onori, P.
name: Salvatori, F.M.
name: Berloco, P.B.
name: Reid, L.M.
name: Nevi, L.
name: Ridola, L.
name: Brunelli, R.
name: Aliberti, C.
name: Rossi, M.
name: Napoletano, C.
name: Rahimi, H.
name: Venere, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundEfforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the present study, we described the first procedure of via hepatic artery transplantation of human fetal biliary tree stem cells in patients with advanced cirrhosis.MethodsThe cells were immune-sorted from human fetal biliary tree by protocols in accordance with current good manufacturing practice (cGMP) and extensively characterized. Two patients with advanced liver cirrhosis (Child-Pugh C) have been submitted to the procedure and observed through a 12months follow-up.ResultsThe resulting procedure was found absolutely safe. Immuno-suppressants were not required, and the patients did not display any adverse effects correlated with cell transplantation or suggestive of immunological complications. From a clinical point of view, both patients showed biochemical and clinical improvement during the 6month follow-up and the second patient maintained a stable improvement for 12months.ConclusionThis report represents proof of the concept that the human fetal biliary tree stem cells are a suitable and large source for cell therapy of liver cirrhosis. The isolation procedure can be carried out under cGMP conditions and, finally, the infusion procedure is easy and safe for the patients. This represents the basis for forthcoming controlled clinical trials.Electronic supplementary materialThe online version of this article (doi:10.1186/s12876-014-0204-z) contains supplementary material, which is available to authorized users.