cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ZO Proteins Redundantly Regulate the Transcription Factor DbpA/ZONAB
Creators: name: Spadaro, Domenica
name: Tapia, Rocio
name: Jond, Lionel
name: Citi, Sandra
name: Fanning, Alan S.
name: Sudol, Marius
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The localization and activities of DbpA/ZONAB and YAP transcription factors are in part regulated by the density-dependent assembly of epithelial junctions. DbpA activity and cell proliferation are inhibited by exogenous overexpression of the tight junction (TJ) protein ZO-1, leading to a model whereby ZO-1 acts by sequestering DbpA at the TJ. However, mammary epithelial cells and mouse tissues knock-out for ZO-1 do not show increased proliferation, as predicted by this model. To address this discrepancy, we examined the localization and activity of DbpA and YAP in Madin-Darby canine kidney cells depleted either of ZO-1, or one of the related proteins ZO-2 and ZO-3 (ZO proteins), or all three together. Depletion of only one ZO protein had no effect on DbpA localization and activity, whereas depletion of ZO-1 and ZO-2, which is associated with reduced ZO-3 expression, resulted in increased DbpA localization in the cytoplasm. Only depletion of ZO-2 reduced the nuclear import of YAP. Mammary epithelial (Eph4) cells KO for ZO-1 showed junctional DbpA, demonstrating that ZO-1 is not required to sequester DbpA at junctions. However, further depletion of ZO-2 in Eph4 ZO-1KO cells, which do not express ZO-3, caused decreased junctional localization and expression of DbpA, which were rescued by the proteasome inhibitor MG132. In vitro binding assays showed that full-length ZO-1 does not interact with DbpA. These results show that ZO-2 is implicated in regulating the nuclear shuttling of YAP, whereas ZO proteins redundantly control the junctional retention and stability of DbpA, without affecting its shuttling to the nucleus.
Bridging Soft-Hard Transport Properties of Quark-Gluon Plasmas with CUJET3.0
Creators: name: Xu, Jiechen
name: Liao, Jinfeng
name: Gyulassy, Miklos
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A new model of jet quenching in nuclear collisions, CUJET3.0, is constructed by generalizing the perturbative QCD based CUJET2.0 model to include two complementary non-perturbative features of the QCD confinement cross-over phase transition near $T_c\approx 160$ MeV: (1) the suppression of quark and gluon degrees of freedom and (2) the emergence of chromo-magnetic monopole degrees of freedom. Such a semi-Quark-Gluon-Monopole Plasma (sQGMP) microscopic scenario is tested by comparing predictions of the leading hadron nuclear modification factors, $R^h_{AA}(p_T>10{\rm GeV/c},\sqrt{s})$, and their azimuthal elliptic asymmetry $v^h_2(p_T>10{\rm GeV/c},\sqrt{s})$ with available data on $h=π,D,B$ jet fragments from nuclear collisions at RHIC($\sqrt{s}=0.2$ ATeV) and LHC($\sqrt{s}$=2.76 ATeV). The sQGMP model is shown to solve the long standing $R_{AA}$ vs $v_2$ puzzle by predicting a maximum of the jet quenching parameter field $\hat{q}(E,T)/T^3$ near $T_c$. The consistency of jet quenching with observed bulk perfect fluidity is demonstrated by extrapolating the sQGMP $\hat{q}$ down to thermal energy $E\sim 3 T$ scales and showing that the sQGMP shear viscosity to entropy density ratio $η/s \approx T^3/\hat{q}$ falls close to the unitarity bound, $1/4π$, in the range $(1-2)T_c$. Detailed comparisons of CUJET2.0 and CUJET3.0 reveal that the remarkably different $\hat{q}(T)$ could be consistent with the same $R_{AA}$ data and could only be distinguished by anisotropy observables. These findings demonstrate clearly the inadequacy of focusing on the jet path averaged quantity $$ as the only relevant medium property to characterize jet quenching, and point to the crucial roles of other essential factors, such as the chromo electric and magnetic composites of the plasma, the screening masses and the running couplings at multiple scales that all strongly influence jet energy loss.
description: 50 pages, 14 figures; v3: typos corrected, new references and discussions included; published in JHEP
2- O -Sulfated Domains in Syndecan-1 Heparan Sulfate Inhibit Neutrophil Cathelicidin and Promote Staphylococcus aureus Corneal Infection
Creators: name: Linhardt, Robert J.
name: Hayashida, Atsuko
name: Amano, Shiro
name: Gallo, Richard L.
name: Liu, Jian
name: Park, Pyong Woo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Ablation of syndecan-1 in mice is a gain of function mutation that enables mice to significantly resist infection by several bacterial pathogens. Syndecan-1 shedding is induced by bacterial virulence factors, and inhibition of shedding attenuates bacterial virulence, whereas administration of purified syndecan-1 ectodomain enhances virulence, suggesting that bacteria subvert syndecan-1 ectodomains released by shedding for their pathogenesis. However, the pro-pathogenic functions of syndecan-1 ectodomain have yet to be clearly defined. Here, we examined how syndecan-1 ectodomain enhances Staphylococcus aureus virulence in injured mouse corneas. We found that syndecan-1 ectodomain promotes S. aureus corneal infection in an HS-dependent manner. Surprisingly, we found that this pro-pathogenic activity is dependent on 2-O-sulfated domains in HS, indicating that the effects of syndecan-1 ectodomain are structure-based. Our results also showed that purified syndecan-1 ectodomain and heparan compounds containing 2-O-sulfate motifs inhibit S. aureus killing by antimicrobial factors secreted by degranulated neutrophils, but does not affect intracellular phagocytic killing by neutrophils. Immunodepletion of antimicrobial factors with staphylocidal activities demonstrated that CRAMP, a cationic antimicrobial peptide, is primarily responsible for S. aureus killing among other factors secreted by degranulated neutrophils. Furthermore, we found that purified syndecan-1 ectodomain and heparan compounds containing 2-O-sulfate units potently and specifically inhibit S. aureus killing by synthetic CRAMP. These results provide compelling evidence that a specific subclass of sulfate groups, and not the overall charge of HS, permits syndecan-1 ectodomains to promote S. aureus corneal infection by inhibiting a key arm of neutrophil host defense.
(3886) James MacFarlane
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantum radiation reaction in laser-electron beam collisions
Creators: name: Blackburn, T. G.
name: Ridgers, C. P.
name: Kirk, J. G.
name: Bell, A. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is possible using current high intensity laser facilities to reach the quantum radiation reaction regime for energetic electrons. An experiment using a wakefield accelerator to drive GeV electrons into a counterpropagating laser pulse would demonstrate the increase in the yield of high energy photons caused by the stochastic nature of quantum synchrotron emission: we show that a beam of $10^9$ 1 GeV electrons colliding with a 30 fs laser pulse of intensity $10^{22}~\text{Wcm}^{-2}$ will emit 6300 photons with energy greater than 700 MeV, $60\times$ the number predicted by classical theory.
Study of digestive enzymes in wild specimens of Sepia officinalis (Linnaeus, 1758) and Octopus vulgaris (Cuvier, 1797)
Creators: name: MANCUSO, Monique
name: GIORDANO, Daniela
name: GENOVESE, Lucrezia
name: DENARO, Maria Gabriella
name: CARUSO, Gabriella
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: The distribution of digestive enzymes in different organs (salivary gland, stomach, caecum and digestive gland) of wild cuttlefish (Sepia officinalis) and common octopus (Octopus vulgaris) specimens was studied in order to set up feeding regimes for these attractive candidate species for Mediterranean aquaculture. In both species, a high content of total proteases was measured, in agreement with their carnivorous diet; these enzymes showed higher activities in the salivary gland. Trypsin and chymotrypsin were higher in the salivary gland of cuttlefish than in common octopus, although no significant differences between both species were found. In common octopus trypsin and chymotrypsin predominated in caecum. Amylase content was high in the salivary gland, with similar levels in octopus and cuttlefish. Overall, the enzymatic patterns found in the examined specimens suggested the occurrence of a wide range of digestive enzymes in the salivary gland, decreasing values of amylase from salivary gland to caecum and the preferential localisation of lipase in the digestive gland.
New fish records from the marine waters of Iraq
Creators: name: AL-BADRI, Majid E.
name: JAWAD, Laith A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: New records of two fish species from the Arabian Gulf coast of Iraq are reported: the seabream Acanthopagrus catenula and the yellowtail tang, Zebrasoma xanthurum. All specimens were obtained from the Iraqi waters of the Arabian Gulf during an ichthyologic survey on the 7th March 2012. Specimens captured included small and large individuals, indicating possible establishment of these species in the area. The specimens of Z. xanthurum obtained in this study include the record size for this species. Several factors may explain the presence of these species in the Iraqi waters of the Arabian Gulf.
Monthly variations of haematological parameters of Sparus aurata and Dicentrarchus labrax reared in Mediterranean land off-shore tanks
Creators: name: FAGGIO, Caterina
name: PICCIONE, Giuseppe
name: MARAFIOTI, Simona
name: ARFUSO, Francesca
name: TRISCHITTA, Francesca
name: FORTINO, Gianluca
name: FAZIO, Francesco
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: The aim of this study was to investigate changes in haematological and biometric parameters in relations to monthly variations in sea bream and sea bass reared in Mediterranean land off-shore tanks. For this purpose, each month (from October 2010 until June 2011), haematological profile was assessed on 25 Sparus aurata and on 25 Dicentrarchus labrax randomly captured from the same batches in Sicilian farm. The application of one way ANOVA showed a strong significant effect of time on all blood parameters in both species that showed similar trend in Red Blood cell count (RBC), Haematocrit (Hct), Haemoglobin concentration (Hgb) and in White Blood Cell count (WBC). RBC and Hct showed highest values in January; from December until February Hgb was higher respect to other months; in sea bream WBC assumed highest values in February while in sea bass WBC was highest in January. Thrombocyte Count (TC) was highest in November and after a decrease during cold months, it rose again in spring. These results obtained could improve the understanding of the influence of seasonal variations on the haemotological and biometric parameters in fish in order to optimize the husbandry practices.
GLEAM: The GaLactic and Extragalactic All-sky MWA survey
Creators: name: Wayth, R. B.
name: Lenc, E.
name: Bell, M. E.
name: Callingham, J. R.
name: Dwarakanath, K. S.
name: Franzen, T. M. O.
name: For, B. -Q.
name: Gaensler, B.
name: Hancock, P.
name: Hindson, L.
name: Hurley-Walker, N.
name: Jackson, C. A.
name: Johnston-Hollitt, M.
name: Kapinska, A. D.
name: McKinley, B.
name: Morgan, J.
name: Offringa, A. R.
name: Procopio, P.
name: Staveley-Smith, L.
name: Wu, C.
name: Zheng, Q.
name: Trott, C. M.
name: Bernardi, G.
name: Bowman, J. D.
name: Briggs, F.
name: Cappallo, R. J.
name: Corey, B. E.
name: Deshpande, A. A.
name: Emrich, D.
name: Goeke, R.
name: Greenhill, L. J.
name: Hazelton, B. J.
name: Kaplan, D. L.
name: Kasper, J. C.
name: Kratzenberg, E.
name: Lonsdale, C. J.
name: Lynch, M. J.
name: McWhirter, S. R.
name: Mitchell, D. A.
name: Morales, M. F.
name: Morgan, E.
name: Oberoi, D.
name: Ord, S. M.
name: Prabu, T.
name: Rogers, A. E. E.
name: Roshi, A.
name: Shankar, N. Udaya
name: Srivani, K. S.
name: Subrahmanyan, R.
name: Tingay, S. J.
name: Waterson, M.
name: Webster, R. L.
name: Whitney, A. R.
name: Williams, A.
name: Williams, C. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: GLEAM, the GaLactic and Extragalactic All-sky MWA survey, is a survey of the entire radio sky south of declination +25 deg at frequencies between 72 and 231 MHz, made with the Murchison Widefield Array (MWA) using a drift scan method that makes efficient use of the MWA's very large field-of-view. We present the observation details, imaging strategies and theoretical sensitivity for GLEAM. The survey ran for two years, the first year using 40 kHz frequency resolution and 0.5 s time resolution; the second year using 10 kHz frequency resolution and 2 s time resolution. The resulting image resolution and sensitivity depends on observing frequency, sky pointing and image weighting scheme. At 154 MHz the image resolution is approximately 2.5 x 2.2/cos(DEC+26.7) arcmin with sensitivity to structures up to ~10 deg in angular size. We provide tables to calculate the expected thermal noise for GLEAM mosaics depending on pointing and frequency and discuss limitations to achieving theoretical noise in Stokes I images. We discuss challenges, and their solutions, that arise for GLEAM including ionospheric effects on source positions and linearly polarised emission, and the instrumental polarisation effects inherent to the MWA's primary beam.
description: 17 pages, 7 Figures, 4 tables. Accepted for publication in the Publications of the Astronomical Society of Australia (PASA)
(3887) Jane Pollock
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ÉTUDE DES PHÉNOMÈNES CHROMATIQUES DE LYSMATA SETICAUDATA RISSO (CRUSTACÉ DÉCAPODE). II.- EFFETS DE L'ABLATION DES PÉDONCULES OCULAIRES SUR LE CYCLE NYCTHÉMÉRAL
Creators: name: CHASSARD-BOUCHAUD, Colette
name: COUTURIER, Yvonne
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: The colour-pattern of Lysmata seticaudata is characterized by two types of red chromatophores which are morphologically and physiologically different. They exhibit an opposite daily rhythm of pigment migration: type I is expanded by day and concentrated at night but type II is concentrated by day and expanded at night.
Bilateral ablation of the eyestalks results in two sets of data: type II continues to exhibit a persistent and increased daily rhythm of colour change while type I shows a complete cessation of the rhythm. The results of our investigations confirm the opposite characters of both types of pigment cells; they enable us to postulate the existence of two neurosecretory mechanisms, each of them controlling one type of chromatophore.
A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin
Creators: name: Ait-Si-ali, Slimane
name: Davis, Ian J.
name: Pattenden, Samantha G.
name: Simon, Jeremy M.
name: Rothbart, Scott B.
name: Jin, Jian
name: Liu, Feng
name: Mosley, Amber L.
name: Parker, Joel S.
name: Strahl, Brian D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: G9a and GLP lysine methyltransferases form a heterodimeric complex that is responsible for the majority of histone H3 lysine 9 mono- and di-methylation (H3K9me1/me2). Widely interspaced zinc finger (WIZ) associates with the G9a-GLP protein complex, but its role in mediating lysine methylation is poorly defined. Here, we show that WIZ regulates global H3K9me2 levels by facilitating the interaction of G9a with chromatin. Disrupting the association of G9a-GLP with chromatin by depleting WIZ resulted in altered gene expression and protein-protein interactions that were distinguishable from that of small molecule-based inhibition of G9a/GLP, supporting discrete functions of the G9a-GLP-WIZ chromatin complex in addition to H3K9me2 methylation.
In situ Evidence of Breaking the Ion Frozen-in Condition via the Non-gyrotropic Pressure Effect in Magnetic Reconnection
Creators: name: Dai, Lei
name: Wang, Chi
name: Angelopoulos, Vassilis
name: Glassmeier, Karl-Heinz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: For magnetic reconnection to proceed, the frozen-in condition for both ion fluid and electron fluid in a localized diffusion region must be violated by inertial effects, thermal pressure effects, or inter-species collisions. It has been unclear which underlying effects unfreeze ion fluid in the diffusion region. By analyzing in-situ THEMIS spacecraft measurements at the dayside magnetopause, we present clear evidence that the off-diagonal components of the ion pressure tensor is mainly responsible for breaking the ion frozen-in condition in reconnection. The off-diagonal pressure tensor, which corresponds to a nongyrotropic pressure effect, is a fluid manifestation of ion demagnetization in the diffusion region. From the perspective of the ion momentum equation, the reported non-gyrotropic ion pressure tensor is a fundamental aspect in specifying the reconnection electric field that controls how quickly reconnection proceeds.
(3883) Waldo Hastie Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Certain aspects of holomorphic function theory on some genus zero arithmetic groups
Creators: name: Jorgenson, Jay
name: Smajlovic, Lejla
name: Then, Holger
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: There are a number of fundamental results in the study of holomorphic function theory associated to the discrete group PSL(2,Z) including the following statements: The ring of holomorphic modular forms is generated by the holomorphic Eisenstein series of weight four and six; the smallest weight cusp form Delta has weight twelve and can be written as a polynomial in E4 and E6; and the Hauptmodul j can be written as a multiple of E4 cubed divided by Delta. The goal of the present article is to seek generalizations of these results to some other genus zero arithmetic groups, namely those generated by Atkin-Lehner involutions of level N with square-free level N.
(3884) John Bryson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone
Creators: name: Tyrrell, Jean
name: Salathe, Matthias
name: Tarran, Robert
name: Manzanares, Dahis
name: Krick, Stefanie
name: Baumlin, Nathalie
name: Dennis, John S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Transforming growth factor β1 (TGF-β1) is not only elevated in airways of cystic fibrosis (CF) patients, whose airways are characterized by abnormal ion transport and mucociliary clearance, but TGF-β1 is also associated with worse clinical outcomes. Effective mucociliary clearance depends on adequate airway hydration, governed by ion transport. Apically expressed, large-conductance, Ca2+- and voltage-dependent K+ (BK) channels play an important role in this process. In this study, TGF-β1 decreased airway surface liquid volume, ciliary beat frequency, and BK activity in fully differentiated CF bronchial epithelial cells by reducing mRNA expression of the BK γ subunit leucine-rich repeat-containing protein 26 (LRRC26) and its function. Although LRRC26 knockdown itself reduced BK activity, LRRC26 overexpression partially reversed TGF-β1-induced BK dysfunction. TGF-β1-induced airway surface liquid volume hyper-absorption was reversed by the BK opener mallotoxin and the clinically useful TGF-β signaling inhibitor pirfenidone. The latter increased BK activity via rescue of LRRC26. Therefore, we propose that TGF-β1-induced mucociliary dysfunction in CF airways is associated with BK inactivation related to a LRRC26 decrease and is amenable to treatment with clinically useful TGF-β1 inhibitors.
Effective Ginzburg-Landau free energy functional for multi-band isotropic superconductors
Creators: name: Grigorishin, Konstantin V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: It has been shown that interband mixing of gradients of two order parameters (drag effect) in an isotropic bulk two-band superconductor plays important role - such a quantity of the intergradients coupling exists that the two-band superconductor is characterized with a single coherence length and a single Ginzburg-Landau (GL) parameter. Other quantities or neglecting of the drag effect lead to existence of two coherence lengths and dynamical instability due to violation of the phase relations between the order parameters. Thus so-called type-1.5 superconductors are impossible. An approximate method for solving of set of GL equations for a multi-band superconductor has been developed: using the result about the drag effect it has been shown that the free-energy functional for a multi-band superconductor can be reduced to the GL functional for an effective single-band superconductor.
description: arXiv admin note: text overlap with arXiv:1007.1107 by other authors
An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS
Creators: name: Kemp, Michael G.
name: Kim, Sook Kyung
name: Kim, So Young
name: Sancar, Aziz
name: Choi, Jun Hyuk
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: DNA damage by UV and UV-mimetic agents elicits a set of inter-related responses in mammalian cells, including DNA repair, DNA damage checkpoints, and apoptosis. Conventionally, these responses are analyzed separately using different methodologies. Here we describe a unified approach that is capable of quantifying all three responses in parallel using lysates from the same population of cells. We show that a highly sensitive in vivo excision repair assay is capable of detecting nucleotide excision repair of a wide spectrum of DNA lesions (UV damage, chemical carcinogens, and chemotherapeutic drugs) within minutes of damage induction. This method therefore allows for a real-time measure of nucleotide excision repair activity that can be monitored in conjunction with other components of the DNA damage response, including DNA damage checkpoint and apoptotic signaling. This approach therefore provides a convenient and reliable platform for simultaneously examining multiple aspects of the DNA damage response in a single population of cells that can be applied for a diverse array of carcinogenic and chemotherapeutic agents.
GIT semistability of Hilbert points of Milnor algebras
Creators: name: Fedorchuk, Maksym
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Our first result is that a homogeneous form $F$ in $n$ variables is GIT semistable with respect to the natural $SL(n)$-action if and only if the first non-trivial Hilbert point of the associated Milnor algebra is semistable. We also prove that the induced morphism on the GIT quotients is finite, and injective on the locus of stable forms. Our second result is that the associated form of $F$, also known as the Macaulay inverse system of the Milnor algebra of $F$, and which is apolar to the last non-trivial Hilbert point of the Milnor algebra, is GIT semistable whenever $F$ is a smooth form. These two results answer questions of Alper and Isaev from arXiv:1407.6838.
description: 19 pages, to appear in Math. Ann
The time resolved measurement of ultrashort THz-band electric fields without an ultrashort probe
Creators: name: Walsh, David A.
name: Snedden, Edward W.
name: Jamison, Steven P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The time-resolved detection of ultrashort pulsed THz-band electric field temporal profiles without an ultrashort laser probe is demonstrated. A non-linear interaction between a narrow-bandwidth optical probe and the THz pulse transposes the THz spectral intensity and phase information to the optical region, thereby generating an optical pulse whose temporal electric field envelope replicates the temporal profile of the real THz electric field. This optical envelope is characterised via an autocorrelation based FROG measurement, hence revealing the THz temporal profile. The combination of a narrow-bandwidth, long duration, optical probe and self-referenced FROG makes the technique inherently immune to timing jitter between the optical probe and THz pulse, and may find particular application where the THz field is not initially generated via ultrashort laser methods, such as the measurement of longitudinal electron bunch profiles in particle accelerators.
description: 7 pages, 3 figures, submitted to APL
DENSITY VARIATIONS AND POPULATION-STRUCTURE OF EURYDICE-INERMIS AND EURYDICE-TRUNCATA (ISOPODA, CIROLANIDAE) IN THE NEUSTON OF GALWAY BAY (IRELAND)
Creators: name: Tully, O.
name: Oceidigh, P.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1986

Abstract
(3879) Isabel Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3881) Jessie Robertson Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease
Creators: name: Joshi, Sameer M.
name: Li, Zibo
name: Llop, Jordi
name: Arsequell, Gemma
name: Preshlock, Sean
name: Gouverneur, Véronique
name: Wilson, Thomas C.
name: Gómez-Vallejo, Vanessa
Publisher: name: MDPI
Year: 2024

description: The small-molecule iododiflunisal (IDIF) is a transthyretin (TTR) tetramer stabilizer and acts as a chaperone of the TTR-Amyloid beta interaction. Oral administration of IDIF improves Alzheimer’s Disease (AD)-like pathology in mice, although the mechanism of action and pharmacokinetics remain unknown. Radiolabeling IDIF with positron or gamma emitters may aid in the in vivo evaluation of IDIF using non-invasive nuclear imaging techniques. In this work, we report an isotopic exchange reaction to obtain IDIF radiolabeled with 18F. [19F/18F]exchange reaction over IDIF in dimethyl sulfoxide at 160 °C resulted in the formation of [18F]IDIF in 7 ± 3% radiochemical yield in a 20 min reaction time, with a final radiochemical purity of >99%. Biodistribution studies after intravenous administration of [18F]IDIF in wild-type mice using positron emission tomography (PET) imaging showed capacity to cross the blood-brain barrier (ca. 1% of injected dose per gram of tissue in the brain at t > 10 min post administration), rapid accumulation in the liver, long circulation time, and progressive elimination via urine. Our results open opportunities for future studies in larger animal species or human subjects.
Comparative morphology of the feeding apparatus in the Terebellida (Annelida: Polychaeta)
Creators: name: ZHADAN, Anna E.
name: TZETLIN, Alexander B.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: The morphology of buccal parts was studied in twenty representative species of Terebellida belonging to the
 families Terebellidae, Ampharetidae, Trichobranchidae and Pectinariidae. The ultrastructure of the ventral pharyngeal organ
 was studied in Ampharete lindstroemii and juveniles of Nicolea zostericola and Pectinaria hyperborea. The ventral
 pharyngeal organ consists of investing muscle fibres and a bulbous muscle including muscle and interstitial cells. A
 glandular ridge is found in the posterior part of the bulbous muscle. No such structures were observed in Pectinaria
 hyperborea. The upper lip in representatives of Terebellidae, Trichobranchidae, Ampharetidae, and Alvinellidae is similar in
 structure. It consists of an area of tentacle attachment and a free edge. In contrast, the upper lip in Pectinariidae has no free
 edge. A hypothesis on the evolution of the buccal apparatus in the Terebellida is proposed. A distinct prostomium and
 tentacles located on the upper lip outside the mouth (as in Ampharetidae with everted tentacles) are considered to be a
 plesiomorphic pattern. The ciliated surface of the dorsal part of the buccal cavity in the Terebellida is considered to be
 homologous to the dorso-lateral folds found in most polychaete taxa.
Faunistic analysis of Syllidae (Annelida: Polychaeta) from the Aegean Sea
Creators: name: ÇINAR, Melih Ertan
name: ERGEN, Zeki
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: A faunistic analysis of a total of 121 benthic samples collected from 31 stations in the infralittoral zone of the
 Aegean Sea, on various substrata and at various depths, yielded a total of 90 syllid species (18957 individuals). Four species
 are newly reported for the Mediterranean fauna and 27 species for the Eastern Mediterranean. Further, 60 species out of 90
 are newly reported for the fauna of Turkey. Some comments on the Mediterranean syllids are provided.
Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair
Creators: name: Hu, Jinchuan
name: Kemp, Michael G.
name: Sancar, Aziz
name: Lindsey-Boltz, Laura A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Ribonucleotides are incorporated into the genome during DNA replication. The enzyme RNase H2 plays a critical role in targeting the removal of these ribonucleotides from DNA, and defects in RNase H2 activity are associated with both genomic instability and the human autoimmune/inflammatory disorder Aicardi-Goutières syndrome. Whether additional general DNA repair mechanisms contribute to ribonucleotide removal from DNA in human cells is not known. Because of its ability to act on a wide variety of substrates, we examined a potential role for canonical nucleotide excision repair in the removal of ribonucleotides from DNA. However, using highly sensitive dual incision/excision assays, we find that ribonucleotides are not efficiently targeted by the human nucleotide excision repair system in vitro or in cultured human cells. These results suggest that nucleotide excision repair is unlikely to play a major role in the cellular response to ribonucleotide incorporation in genomic DNA in human cells.
SUR LE RÔLE DU CERVEAU DANS L'OSMORÉGULATION CHEZ LES NÉREIDIENS (ANNÉLIDES POLYCHÈTES)
Creators: name: DE LEERSNYDER, Monique
name: DURCHON, Maurice
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: Removal of the brain does not suppress the regulation of water-balance and hypertonicity of the body fluid by the Nereidae Nereis diversicolor O.F. Müller and Perinereis cultrifera Grübe transferred from normal to dilute or concentrated sea water.
Ab-Initio Theory of Superconductivity in a Magnetic Field II. : Numerical solution
Creators: name: Linscheid, A.
name: Sanna, A.
name: Gross, E. K. U.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We numerically investigate the Spin Density Functional theory for superconductors (SpinSCDFT) and the approximated exchange-correlation functional, derived and presented in the preceding paper I. As a test system we employ a free electron gas featuring an exchange-splitting, a phononic pairing field and a Coulomb repulsion. SpinSCDFT results are compared with Sarma, the Bardeen Cooper and Schrieffer theory and with an Eliashberg type of approach. We find that the spectrum of the superconducting Kohn-Sham SpinSCDFT system is not in agreement with the true quasi particle structure. Therefore, starting from the Dyson equation, we derive a scheme that allows to compute the many body excitations of the superconductor and represents the extension to superconductivity of the G0W0 method in band structure theory. This superconducting G0 W0 method vastly improves the predicted spectra.
First record of anomalous blue-spotted spinefoot, Siganus corallinus (Valenciennes, 1835) with vertebral deformities from Aldabra Island, Seychelles
Creators: name: JAWAD, Laith A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2014

description: Vertebral deformity and fusion are reported in blue-spotted spinefoot, Siganus corallinus (Siganidae) collected from Aldabra, Seychelles. One abdominal and four caudal vertebrae are involved in this anomaly and found in two areas along the vertebral column. In addition, a minor anomaly was also noticed in the abnormal specimen. Possible causes such as genetic and epigenetic factors may be implicated in this anomaly.
Aristonerilla: a new nerillid genus (Annelida: Polychaeta) with description of Aristonerilla (Micronerilla) brevis comb. nov. from a seawater aquarium
Creators: name: MÜLLER, Monika C. M.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: A nerillid polychaete is described from the organic-filter system of a marine aquarium in the AquaZoo
 (Düsseldorf, Germany). The body comprises the prostomium, seven segments and the pygidium. With two large,
 ventrolateral palps and three long, threadlike antennae, the species possesses the maximal number of prostomial appendages
 present in this taxon. Two small eyes are visible. The first segment (buccal segment, peristomium) contains a pair of small
 parapodia without cirri but with a few, relatively long chaetae. Segments II to VI possess parapodial cirri, increasing in length
 posteriorly. In segment VII the cirri are reduced. Each trunk segment has one dorsal and one ventral bundle of chaetae, which
 are slightly longer than the parapodial cirri. All chaetae are compound; some possess very long blades. The pygidium carries
 two threadlike anal cirri. Apart from minor morphometrical and anatomical differences, the animals resemble Micronerilla
 brevis. However, the type species Micronerilla minuta, does not possess seven but eight segments and because the number
 of segments is considered a stable character in nerillid genera, the species brevis, with seven segments, has to be placed in
 a new genus, Aristonerilla, and named Aristonerilla brevis (new comb.).
Description of Ancorabolus hendrickxi sp. nov. (Copepoda: Harpacticoida: Ancorabolidae) from the neotropics and notes on caudal ramus development within oligoarthran harpacticoids
Creators: name: GÓMEZ, Samuel
name: CONROY-DALTON, Sophie
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: A single female specimen of Ancorabolus hendrickxi sp. nov. (Harpacticoida: Ancorabolidae) was found in
 meiofauna samples taken off Sinaloa (North-western Mexico) at a depth of 1985 m. Parsimony analysis of the Ancorabolus-
 lineage including this new species, confirmed Conroy-Dalton & Huys' (2000) conclusions on the monophyly of Ancorabolus
 and the validity of both Breviconia and Juxtaramia, and identified the Scandinavian Ancorabolus confusus as the closest
 relative of A. hendrickxi sp. nov.  Both species show close similarity in the general body shape, length and pattern of
 integumental processes on the cephalothorax and body somites, elongate and slender caudal rami, absence of proximal
 recurved process on posterior margin of second antennulary segment and presence of an inner seta on the second endopodal
 segment of the second swimming leg. Ancorabolus hendrickxi sp. nov. can be readily differentiated from its congeners by
 the complete lack of a maxillulary coxal endite, the mandibular palp with five setae, and the very reduced proximal endite
 of the maxillary syncoxa bearing only one seta. Re-evaluation of the taxonomic status of the recently described species
A. ilvae from the Magellan Straits, Chile demonstrates that it can only be regarded as species inquirenda in Ancorabolus. An
 updated generic diagnosis of Ancorabolus is provided. Postembryonic caudal ramus development within oligoarthran
 harpacticiods is analysed, based on observations of A. confusus, Macrosetella gracilis and Microarthridion sp., and
 additional literature data. A generalized developmental pattern of caudal rami, based on vertical tracking of the homology
 of caudal setae I-VII throughout ontogeny is proposed.
CDK1-dependent Inhibition of the E3 Ubiquitin Ligase CRL4 CDT2 Ensures Robust Transition from S Phase to Mitosis
Creators: name: Varma, Dileep
name: Coleman, Kate E.
name: Cook, Jeanette Gowen
name: Rizzardi, Lindsay F.
name: Matson, Jacob P.
name: Oh, Seeun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Replication-coupled destruction of a cohort of cell cycle proteins ensures efficient and precise genome duplication. Three proteins destroyed during replication via the CRL4CDT2 ubiquitin E3 ligase, CDT1, p21, and SET8 (PR-SET7), are also essential or important during mitosis, making their reaccumulation after S phase a critical cell cycle event. During early and mid-S phase and during DNA repair, proliferating cell nuclear antigen (PCNA) loading onto DNA (PCNADNA) triggers the interaction between CRL4CDT2 and its substrates, resulting in their degradation. We have discovered that, beginning in late S phase, PCNADNA is no longer sufficient to trigger CRL4CDT2-mediated degradation. A CDK1-dependent mechanism that blocks CRL4CDT2 activity by interfering with CDT2 recruitment to chromatin actively protects CRL4CDT2 substrates. We postulate that deliberate override of replication-coupled destruction allows anticipatory accumulation in late S phase. We further show that (as for CDT1) de novo SET8 reaccumulation is important for normal mitotic progression. In this manner, CDK1-dependent CRL4CDT2 inactivation contributes to efficient transition from S phase to mitosis.
A new species of carnivorous deep-sea sponge (Demospongiae: Cladorhizidae) associated with methanotrophic bacteria
Creators: name: VACELET, Jean
name: BOURY-ESNAULT, Nicole
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

description: A new species of Cladorhiza, C. methanophila sp. nov., is described from mud volcano fields and active sites of
 methane expulsion in the Barbados Trench, from 4700 to 4900 m depth. This species, the first reliable record of the genus
 in the Central Eastern Atlantic, is both carnivorous and associated with methanotrophic bacteria.
(3882) Alexander D Cameron
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SUR LE GENRE LILYOPSIS CHUN 1885, AVEC UNE REDESCRIPTION DE L'ESPÈCE LILYOPSIS ROSEA CHUN 1885 (SIPHONOPHORE, PRAYINAE) ET UNE DESCRIPTION DE SA PHASE CALYCONULA
Creators: name: CARRÉ, Claude
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: The observation of several specimens of Siphonophores of the genus Lilyopsis, and their breeding in the laboratory, which enabled the renewal of nectophores to be studied, led the author to think that the different species of the genus Lilyopsis, previously described, belong to a single species, Lilyopsis rosea Chun, whose morphological characters are given, and of which be described the calyconula phase.
The author shows that during a great part of its cycle, the colony has two different nectophores, one of them being the larval nectophore ; after the fall of this latter, it has two identical nectophores.
Channel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine Receptor
Creators: name: Mei, Yingwu
name: Xu, Le
name: Wang, Ying
name: Dokholyan, Nikolay V.
name: Pasek, Daniel A.
name: Mowrey, David D.
name: Meissner, Gerhard
name: Giraldez, Raul Mendez
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Type 1 ryanodine receptors (RyR1s) release Ca2+ from the sarcoplasmic reticulum to initiate skeletal muscle contraction. The role of RyR1-G4934 and -G4941 in the pore-lining helix in channel gating and ion permeation was probed by replacing them with amino acid residues of increasing side chain volume. RyR1-G4934A, -G4941A, and -G4941V mutant channels exhibited a caffeine-induced Ca2+ release response in HEK293 cells and bound the RyR-specific ligand [3H]ryanodine. In single channel recordings, significant differences in the number of channel events and mean open and close times were observed between WT and RyR1-G4934A and -G4941A. RyR1-G4934A had reduced K+ conductance and ion selectivity compared with WT. Mutations further increasing the side chain volume at these positions (G4934V and G4941I) resulted in reduced caffeine-induced Ca2+ release in HEK293 cells, low [3H]ryanodine binding levels, and channels that were not regulated by Ca2+ and did not conduct Ca2+ in single channel measurements. Computational predictions of the thermodynamic impact of mutations on protein stability indicated that although the G4934A mutation was tolerated, the G4934V mutation decreased protein stability by introducing clashes with neighboring amino acid residues. In similar fashion, the G4941A mutation did not introduce clashes, whereas the G4941I mutation resulted in intersubunit clashes among the mutated isoleucines. Co-expression of RyR1-WT with RyR1-G4934V or -G4941I partially restored the WT phenotype, which suggested lessening of amino acid clashes in heterotetrameric channel complexes. The results indicate that both glycines are important for RyR1 channel function by providing flexibility and minimizing amino acid clashes.