cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spannbreite der Flexibilisierung von Arbeit: Entscheidungen sind gefragt
Creators: name: Weichbrodt, Johann
Publisher: name: Deutsche Gesellschaft für Personalführung e.V.
Year: 2018
Subjects: subject: Arbeitswelt 4.0
subject: New Work
subject: Flexibilisierung
subject: 150 - Psychologie
subject: 330 - Wirtschaft

description: Unter „Arbeit 4.0“, „New Work“ oder auch „Neue Arbeitswelten“ werden seit einigen Jahren verschiedene Veränderungen in Unternehmen und auf dem Arbeitsmarkt diskutiert. Ein zentraler Aspekt dieser Diskussion ist die Flexibilisierung von Arbeit, womit teils sehr unterschiedliche Varianten von Flexibilisierung gemeint sind. Diese Verände rungen stellen meist keine fundamental neuen Phänomene dar, auf die Beschäftigten und die Unternehmen haben sie gleichwohl und getrieben durch die Digitalisierung erhebliche Auswirkungen.
title: Die rezidivierende Zystitis der Frau – eine Evaluation des Keimspektrums und der Resistenzlage im ländlichen Raum
Creators: name: Spachmann, P. J.
name: Radlmaier, M.
name: Burger, M.
name: Vergho, D.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einführung: Rezidivierende Harnwegsinfekte – insbesondere bei Frauen – stellen eine alltägliche Herausforderung der infektiologischen Urologie dar. Die betroffenen Patientinnen sind häufig stark belastet. Ziel der vorliegenden Studie war eine Evaluation dieses Kollektivs[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
EPSRC Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is an annotated data management plan (DMP) template for an Engineering and Physical Sciences Research Council (EPSRC) data management plan.

This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), the EPSRC and the University of Sheffield Library.
Although the EPSRC does not require that a DMP is submitted as part of a grant application, it still expects one to be in place. A DMP describes how you will collect, organise, manage, store, secure, backup, preserve, and where applicable, share your data. The EPSRC DMP template is organised into seven sections and the resulting DMP is expected to be two or three of pages of A4 in length.
For further guidance see the EPSRC expectations concerning management of research data and the DCC webpages on Data management Plans and How to Develop a Data Management and Sharing Plan.
BBSRC Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is an annotated data management plan (DMP) template for a Biotechnology and Biological Sciences Research Council (BBSRC) data management plan, required for attachment to grant applications.
This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), the BBSRC and the University of Sheffield Library.
Applications for BBSRC grants require the attachment of a data management plan no more than 1 side of A4 in size. Eight themes are proposed that applicants may wish to cover. These themes are built into the DMPonline template for BBSRC plans.
For further guidance see the BBSRC Data Sharing Policy, the BBSRC Research Grants Guide and Application Guidance: Data Management Plan.

The DCC also provides guidance on Data management Plans and How to Develop a Data Management and Sharing Plan.
CRUK Annotated DMP Template
Creators: name: Lewis, John A.
name: Gould, Paula
name: Palmer, Ian
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: This is an annotated data management plan (DMP) template for a Cancer Research UK (CRUK) data sharing plan.
This document (available in .pdf and .docx formats) was created using the DMPonline tool, which provides templates for structuring major research funders' DMPs. The document includes the guidance text provided in the tool, produced by the Digital Curation Centre (DCC), CRUK and the University of Sheffield Library.
A data sharing plan is generally required when applying for CRUK funding. CRUK list eight themes that should be considered, but no page limit is noted.The format of this plan depends on the committee you are applying to:
Applicants to the Science Committee and Clinical Research Committee will be asked to complete a short free text data sharing plan when applying through the electronic grant management system (eGMS). A more detailed plan will be required if the application is successful.
Applicants to the Population Research Committee must upload a full data sharing plan based on the formally structured template as an appendix to their eGMS application.
For further guidance, see the CRUK webpages on Submission of a data sharing and preservation strategy and Practical guidance for researchers on writing data sharing plans.
The DCC also provides guidance on Data management Plans and How to Develop a Data Management and Sharing Plan.
Quality of life at older ages and marital status: gender and welfare regime variation
Creators: name: Abell, Jessica
Publisher: name: Imperial College London
Year: 2013

description: Background: Evidence of an association between marital status and well-being has been demonstrated, with married people reporting higher levels of well-being. However, the strength of this relationship in later life may be influenced by both societal context and gender. This thesis will examine the association between marital status and quality of life in older people and consider if this relationship varies by welfare arrangements and if gender moderates these associations. This research will also explore how quality of life is experienced within married couples. Methods: Quality of life was measured using CASP-12. The relationship with both current and past marital status was examined. Analyses were conducted using data from The Survey of Health, Ageing and Retirement in Europe (SHARE) and the English Longitudinal Study of Ageing (ELSA). A welfare state regime approach was used to examine societal context and due to feminist criticisms of these approaches, two further methods of comparison were used. A dyadic data technique was also used to examine the interdependence of quality of life for married people. Results: Current marital status was found to be a predictor of quality of life at older ages. However, variation in this association was observed across the welfare state regimes. When health and socio-economic circumstances were taken into account, the advantage of marriage for quality of life was often attenuated. Gender differences in this relationship were also observed; especially when gender focused methods were examined. Spousal interdependence of quality of life was also observed within married couples. Conclusions: This research expands our understanding of the association between marriage and well-being by suggesting that societal context is important and that marriage may offer men and women different kinds of protection as they age. It also suggests that for older married couples, quality of life is not just an individual experience.
Mechanisms of Colorectal Cancer Pathogenesis: Role of Hypoxia
Creators: name: Thairu, Ngayu Munga
Publisher: name: Imperial College London
Year: 2013

description: Colorectal cancer (CRC) is the third most common cancer worldwide Hypoxia plays a pivotal role in cancer, regulating cellular processes such as angiogenesis via the Hypoxia Inducible Factor (HIF) pathway. HIF-1α and HIF-2α, isoforms of the α-subunit, were previously thought to be functionally redundant, but mounting evidence supports their divergent roles in many cancers. In CRC their relative roles remain unclear. This study aimed to elucidate their relative contribution to hypoxic regulation of CRC using the Caco-2 cell-line. Ex vivo cultures of primary cells isolated from CRC tissue were used to validate the Caco-2 data. Caco-2 cells were stimulated with hypoxia (1% O2) or the hypoxia-mimetic dimethyloxaloylglycine (DMOG), with normoxia (21% O2) controls. Expression of known hypoxia-induced genes was quantified by polymerase chain reaction (PCR) and a PCR-based array was used to further characterise angiogenic genes. Protein expression was determined using Western Blotting and ELISA. The effect of selective HIF-isoform knockdown on gene expression was evaluated. Tumour-derived cultures (TDCs) were established using tissue obtained from surgically resected CRC specimens. mRNA expression of epithelial cell markers (Ep-CAM, VE-Cadherin) was quantified by Q-PCR, and protein expression of the CRC tumour marker carcinoembryonic antigen (CEA) measured by ELISA. TDCs were exposed to hypoxia, and gene expression relative to normoxia was quantified by Q-PCR and PCR-based array. In Caco-2 cells, hypoxia upregulated both HIF isoform proteins, inducing genes involved in angiogenesis (VEGF, ANGPTL-4, EFNA-3, TGF-β1), metabolism (CA-IX, GLUT-1) and apoptosis (BNIP-3), with mRNA changes reflected at protein level. Three novel hypoxia-induced angiogenesis genes (ANGPTL-4, EFNA-3, TGF-β1) were identified. Hypoxia-induced ANGPTL-4, BNIP-3 and TGF-β1 expression was reduced by siHIF-1α only, while EFNA-3 and VEGF expression was reduced by both siHIF-1α and siHIF-2α. TDCs expressed epithelial CRC cell markers, and showed similar hypoxia-induced angiogenesis gene expression to Caco-2 cells, although there was significant inter-donor variability.
title: Data Stewardship Maturity Report for NOAA Climate Data Record (CDR) of Cloud Properties from AVHRR Pathfinder Atmospheres – Extended (PATMOS-x), Version 5.3
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00296
Mechanism of noble gas neuroprotection in an in vitro model of traumatic brain injury
Creators: name: Harris, Katie
Publisher: name: Imperial College London
Year: 2014

description: Background: The noble gases xenon and argon are neuroprotective in models of brain injury. This thesis investigated the neuroprotective mechanisms of the inert gases xenon, argon, krypton, neon and helium in in vitro models of traumatic brain injury and ischemia. Methods: This study used an in vitro model of focal mechanical trauma and oxygen and glucose deprivation using mouse organotypic hippocampal brain slices. Injury was quantified by propidium iodide fluorescence. Results: Xenon (50.6 kPa) and, to a lesser extent, argon (50.6 kPa) are neuroprotective against traumatic injury when applied after injury (xenon 0.43 ± 0.03 protection at 72 h after injury [N = 104]; argon 0.30 ±0.0% protection [N = 44] vs control injury 1.0±0.05 [N=144]; mean ± SEM). Helium, neon, and krypton are devoid of neuroprotective effect. Xenon (50.6 kPa) prevents development of secondary injury after trauma. Argon (50.6 kPa) attenuates secondary injury, but is less effective than xenon (xenon 0.50 ± 0.05 reduction in secondary injury at 72 h after injury [N = 104]; argon 0.34 ± 0.08 reduction [N = 44] vs control 0.86±0.05 [N = 144]; mean ± SEM). Glycine reverses the neuroprotective effect of xenon, but not argon in both models of TBI and OGD, consistent with competitive inhibition at the N-methyl-d-aspartate receptor glycine site mediating xenon neuroprotection against traumatic brain injury. Conclusions: Xenon neuroprotection against traumatic and ischemic brain injury can be reversed by elevated concentrations of glycine, indicating a key role of inhibition of the NMDA receptor glycine co-agonist site in mediating neuroprotection against these injuries. Argon does not appear to have any effects on NMDA receptors and is neuroprotective via a mechanism distinct to that of xenon. Krypton and neon are devoid of neuroprotective effects in either injury model.
Ventilatory ratio : a simple bedside index to monitor ventilatory efficiency
Creators: name: Sinha, Pratik
Publisher: name: Imperial College London
Year: 2012

description: A lack of a simple index that monitors ventilatory efficiency at the bedside has meant that oxygenation has been the predominant variable that is used to monitor adequacy of ventilatory strategies and disease severity in mechanically ventilated patients. Due to complexities in its measurement, deadspace ventilation, the traditional method to track ventilatory failure, has failed to become integral in the management of mechanically ventilated patients. Ventilatory ratio (VR) is an easy to calculate index that uses variables measured at the bedside: [Mathematical equation appears here. To view, please open pdf attachment] where [Symbols appears here. To view, please open pdf attachment] is taken to be 100 ml.kg-1.min-1 based on predicted body weight and [Symbols appears here. To view, please open pdf attachment] is taken to be 5 kPa. Physiological analysis of VR dictates that it is influenced by deadspace fraction and CO2 production. Physiological analysis of VR was validated in a benchside lung model and a high fidelity computational cardiopulmonary physiology model. The impact of CO2 production on VR was investigated in patients undergoing laparoscopic surgery who received exogenous intraperitoneal CO2. This showed that delta values of the 2 variables were linear. The variability of CO2 production was examined in ICU patients and results of the study showed that variability of CO2 production was small. In an ICU population correlation of VR was stronger with deadspace in comparison to CO2 production. Of these two variables, deadspace had the greater effect on VR. The clinical uses of VR were examined in 4 databases of ICU patients. VR was significantly higher in non-survivors compared to survivors. Higher values of VR were associated with increased mortality and more ventilator days. A rising values of VR over time was also associated with worse outcome. VR is a simple bedside index that provides clinicians with useful information regarding ventilatory efficiency and is associated with outcome.
Partícula
Creators: name: Pablo Martínez Castro
Publisher: name: Zenodo
Year: 2024

description: Biblia transmedia del universo Partícula. Libro creado por como Trabajo de Fin de Grado en la carrera de Bellas Artes.

En el universo de cuántico, las partículas subatómicas adquieren conciencia y habilidades similares a las humanas, coexistiendo en un cosmos infinitesimal donde exploran el espacio-tiempo, desafían la gravedad y viven una vida emocionante. Los seres cuánticos, con una longevidad potencial de millones de años, enfrentan decisiones morales entre apoyar al gobierno o a la revolución, mientras luchan contra la corrupción y problemas persistentes.

Este universo se sitúa en el corazón de estrellas moribundas, donde las fluctuaciones cuánticas de la resonancia cuántica estelar, un fenómeno que ocurre en el último estadio de evolución de estrellas masivas, antes de su colapso en supernovas o agujeros negros, generan seres cuánticos con habilidades únicas imbuidos de la esencia cósmica, destinados a explorar el universo y enfrentar decisiones éticas cruciales.
Additional file 1: of Effect of serum triglyceride level on the prognosis of patients with hepatocellular carcinoma in the absence of cirrhosis
Creators: name: Liu, Xiaoli
name: Li, Mengge
name: Wang, Xinhui
name: Dang, Zhibo
name: Jiang, Yuyong
name: Wang, Xianbo
name: Yang, Zhiyun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Table S1. Changes of lipid parameters in HCC patients without cirrhosis, compensated cirrhosis and decompensated cirrhosis (DOCX 14 kb)
title: Data Stewardship Maturity Report for NOAA Climate Data Record (CDR) of Gridded Satellite Data from ISCCP B1 (GridSat-B1) Infrared Channel Brightness Temperature (TB), Version 2
Creators: name: Hager,, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00291
The IgLON Family in Ovarian Cancer: Functional Characterisation of LSAMP and NEGR1 in Comparison with the Tumour Suppressor OPCML
Creators: name: Christen, Sarah
Publisher: name: Imperial College London
Year: 2012

description: Out of all gynaecological cancers, epithelial ovarian cancer (EOC), a mainly sporadically occurring disease affecting postmenopausal women, exhibits the highest fatality-to-case ratio. Further research is therefore urgently required to combat the disease. In previous studies, our group identified the IgLON protein OPCML to be an important, frequently epigenetically inactivated (>80%) tumour suppressor in EOC. On the molecular level, OPCML functions by directly interacting with and subsequently endocytotically downregulating a broad repertoire of receptor tyrosine kinases (RTKs). During this PhD project, the aim was to determine if LSAMP and NEGR1, two further IgLON family members, function in a similar manner. Bioinformatic approaches as well as in vitro experiments were used to address issues such as sequence similarity, colocalisation or interaction; furthermore, overexpression and knockdown clones were generated to determine the impact of IgLON presence/absence on cellular characteristics such as RTK expression, proliferation or migration. While LSAMP was found to potentially function in a similar manner as OPCML in the ovarian cancer cell line SKOV3 by reducing RTK expression, proliferation and colony formation, its functions in the ovarian epithelial surface cell line OSE-C2 were less clear and require further validation. For NEGR1, a striking downregulation of RTKs, including those which had been unaffected by OPCML in previous experiments – such as EGFR, HER3 or FGFR2 – was observed in transfected SKOV3 cells. Downregulation seemed to occur both via lysosomal and proteasomal pathways, and resulted in substantial reduction of cell proliferation and colony formation. Overall, these results suggest that the IgLON family could function as a broad regulator of RTK expression and function. Since IgLONs are extracellular proteins, they represent excellent subjects for drug development as no intracellular delivery or gene therapy is necessary. To our knowledge, this is the first report investigating the functional properties of LSAMP and NEGR1 in epithelial ovarian cancer.
title: Data Stewardship Maturity Report for GHRSST L3C global sub-skin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on Metop satellites (currently Metop-B) (GDS V2) produced by OSI SAF (GDS version 2)
Creators: name: Ionin, Raisa
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00288
Metabolic profiling and pathway mapping of cardiovascular disease
Creators: name: Vorkas, Panagiotis
Publisher: name: Imperial College London
Year: 2013

description: In this thesis, metabolic profiling (MP) platforms were utilised to interrogate the manifestation of cardiovascular disease and provide candidate biomarkers. A number of LC-MS and NMR methodologies were employed. Data processing was followed by assessment using multivariate (MVDA) and univariate (UV) statistics. MP is applied under three cardiovascular disease themes: 1) plaque rupture, 2) plaque formation, and 3) arterial ectopic calcification. Statistically significant features were structurally assigned. Identified metabolites were mapped to their corresponding biochemical pathways. For MP of ruptured plaque, tissue from symptomatic and asymptomatic patients for stroke was used. After detection of statistically significant features and structural assignment, two biochemical pathways showed dysregulations: the arachidonic acid pathway, indicating increased levels of inflammation, and the β-oxidation pathway with increased levels of three acyl-carnitines. Tissue extracts were used to investigate plaque formation. Arterial intima tissue, incorporating plaque lesions (carotid and femoral), was compared to intimal thickening tissue. Intima thickening demonstrated distinct MP compared to plaques. Plaques from different anatomical locations also demonstrated altered MP. After metabolite assignment, pathway mapping revealed dysregulations common to both anatomical locations. These were cholesterol, ceramide, purine, pyrimidine and β-oxidation pathways. These pathways are related to inflammation and apoptosis. A metabolite previously unassociated to atherogenesis was detected with strong statistical significance (t-test; p≥9.8x10-12), namely phosphatidylethanolamine-ceramide. It also demonstrated high correlations to cholesterol, a well-established risk-factor of atherosclerosis. The third theme of the project explores ectopic cardiovascular calcification. Experiments were conducted on blood serum. Patients with coronary artery and aortic valve calcification were compared with non-calcified controls. Phosphatidylcholine moieties and sphingomyelins were the major discriminating metabolites between cases and controls. These are involved in inflammation and apoptosis. The two diseases manifested different profiles with only three commonly dysregulated metabolites. A number of experiments using additional samples and bottom-up approaches will follow to provide validation of results.
Psychologische Einflussfaktoren auf die Entscheidung für oder gegen eine vegane Ernährung
Creators: name: Iseli, Danila
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: Ernährung
vegan
pflanzenbasiert
psychologische Einflussfaktoren
Wissen
Barrieren
Motive

description: Diese Bachelorarbeit befasst sich mit psychologischen Einflussfaktoren auf die Entscheidung für oder gegen die vegane Ernährung. Es wurden drei Hypothesen untersucht, welche davon ausgehen, dass sich die Ernährungstypen allesessend, flexitarisch, vegetarisch und vegan hinsichtlich (1) Wissen über ernährungsspezifische Auswirkungen auf Gesundheit, Umwelt und Nutztiere, (2) Beurteilung der Schmackhaftigkeit tierischer und pflanzlicher Produkte und (3) Beurteilung des sozialen Umfeldes als Barriere unterscheiden. Auch ernährungsbezogene Motive, Vertrautheit mit dem Thema und weitere Barrieren wurden untersucht. Zu diesem Zweck wurde eine Online-Umfrage mit 960 Teilnehmenden (44% allesessend, 17% flexitarisch, 10% vegetarisch, 25% vegan, 4% Andere), durchgeführt. Für Hypothesen 1 und 2 ergaben sich signifikante Unterschiede zwischen den Ernährungstypen: Die veganen Befragten beantworteten am meisten Wissensfragen korrekt (1); die allesessenden Befragten beurteilten die Schmackhaftigkeit tierischer Produkte am höchsten und die pflanzlicher Produkte am niedrigsten, mit der gegenläufigen Tendenz für die veganen Befragten (2). Das soziale Umfeld (3) erwies sich als weniger starke Barriere.
The structure characterization of hybrid from Enhancement of an organic–metallic hybrid charring agent on flame retardacy of ethylene-vinyl acetate copolymer
Creators: name: Xu, Bo
name: Ma, Wen
name: Shao, Lushan
name: Qian, Lijun
name: Qiu, Yong
Publisher: name: The Royal Society
Year: 2019

description: An organic triazine charring agent hybrid with zinc oxide (OTCA@ZnO) was prepared and well characterized through Fourier transform infrared spectrometry (FTIR), solid-state nuclear magnetic resonance (SSNMR), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA). The flame retardancy and thermal behaviour of intumescent flame retardant EVA composites combining OTCA@ZnO and ammonium polyphosphate (APP) were investigated using limited oxygen index (LOI), UL-94 vertical burning, cone calorimetry and TGA. The structure and morphology of chars were investigated by scanning electron microscopy (SEM), FTIR, laser Raman spectroscopy analysis (LRS) and X-ray photoelectron spectroscopy (XPS). Results revealed that OTCA@ZnO exhibited excellent thermal stability and dispersity after hybridization. The flame retardancy and smoke suppression properties of EVA were significantly improved by introducing APP/OTCA@ZnO. TGA results indicated that APP/OTCA@ZnO presented an excellent synergistic effect and promoted the char formation of EVA composites. Residue analysis results showed more char with high quality connected by richer P–O–C, P–N and P–O–Si structures was formed in APP/OTCA@ZnO system than APP/HOTCA/ZnO system, which consequently suppressed more efficiently the combustion and smoke production due to the in situ catalytic carbonization effect of hybrid.
Novel strategies for the identification of biomarkers of non-Hodgkin lymphoma: evidence from the European Prospective Investigation into Cancer (EPIC)
Creators: name: Kelly, Rachel
Publisher: name: Imperial College London
Year: 2013

description: Non-Hodgkin’s Lymphomas (NHL) represent the eighth most common cancer in Western Europe. Yet despite their widespread prevalence and high mortality rate relatively little is known about the aetiology of these hematological malignancies. Consequently NHL represents an ideal candidate for the discovery of biomarkers lying along the causal pathway. Such biomarkers would allow the improved identification of risk factors and high risk individuals, as well as an enhanced understanding of lymphomageneisis. However, to date there has been little progress in determining validated predictive biomarkers of NHL. This thesis attempts to address some of the issues that have previously hampered the study of NHL through novel strategies of biomarker identification utilising novel methodologies, technologies and statistical techniques. The thesis comprises a nested case-control study within the European Prospective investigation into Cancer (EPIC) cohort and is split into two parts: the ‘validation of biomarkers’ and the ‘integration of biomarkers’. The most exciting finding was the identification of a novel biomarker for Follicular lymphoma based on the t(14;18) translocation which comprises a previously unknown pre-disease condition. Although no other predictive biomarkers were identified this work represents a ‘proof-of-principle’ for the use profile regression in the study of highly dimensional complex datasets, and the possibility of using mass-spectrometry derived metabolic profiles in the study of lymphoma. Part two of the thesis confirmed that the use of the ‘meet-in-the-middle’ approach was a valuable and feasible method for studying the complete causal pathway from risk factor to disease. Together these results highlight potential avenues for further study of NHL and confirm the utility of a number of novel strategies that can aid such work. Additionally it informs on some of the likely challenges that will be involved.
Symbols and Functions in Human Machine Interface: Are Google Icons a Possible Solution for Intercultural Usability?
Creators: name: Christ, Oliver
name: Papageorgiou, Andreas
name: Mutuura, Kamalatharsi
Publisher: name: Springer
Year: 2020
Subjects: subject: Graphical user interface Usability Icons Intercultural
subject: 150 - Psychologie

description: We explored the possibility of taking icons from Android Smartphones, for the use in graphical user interfaces (GUI) in bakery sheeter. This idea was generated from the fact that Android Smartphones are sold worldwide and that the icons used in the menu should have a degree of popularity that most people could deal with. With this research question in mind we created a mixed method design for the study (qualitative and quantitative data). Results show that some icons were able to represent basic navigation function in industrial machines.
title: Data Stewardship Maturity Report for NOAA Climate Data Record of Microwave Sounding Unit (MSU) and Advanced Microwave Sounding Unit (AMSU-A) Mean Layer Temperature, Version 3.0
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00285
What is anu(ta)? – Ācārya dr. Sthaneshwar Timalsina
Creators: name: Timalsina, Staneshwar
Publisher: name: Zenodo
Year: 2022
Subjects: Kali
mahadeva
agama
Mahakali
advaita vedanta
Kubjika
Shiva Sutra
Kashmir Shaivism
Kula
sarvamnaya
Saundaryalahari
krama
Camunda
Shiva
vimarsha-foundation
tantraloka
Spanda
Sadāśiva
Tripura Rahasya
vedanta
Abhinavagupta
saivadvaita
shakti
Guhyakālī
sthaneshwar timalsina
Durga
Bhairava
trika
Divine Mother
shambhava
Tantra
Devi Mahatmya
Tripurasundari
Sarvamnaya
timalsina
tripura
Mālinīvijayottaratantra
consciousness
Kaula
anava upaya
yantra
Īśāna
Vasugupta
shakta upāya
Chandi
Shaiva
sarvamnaya-oral-tradition-archive
Tantric philosophy
amnaya

description: NEXT FREE COURSE offered by Śaivācārya Prof. Sthaneshwar Timalsina: https://www.vimarshafoundation.org/courses

Video source: Vimarsha Foundation's course – Śivajñānabodha – SJB_QA_6_March_2022 – https://www.vimarshafoundation.org/courses

Original YouTube video: https://www.youtube.com/watch?v=9y3BT35Xugw

This presentation is part of the Sarvāmnāya Oral Tradition Archive.
Vimarsha Foundation. (2025). The Sarvāmnāya Oral Tradition Archive [Data set]. Zenodo. https://doi.org/10.5281/zenodo.15188107
Spidroin - Molecule of the Month July 2002 [Archived version]
Creators: name: Li, Vivienne
Publisher: name: figshare
Year: 2017
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: This is the Molecule of the Month entry for July 2002 about spidroin. It is a pdf archive version of the HTML webpage.
Die ewige Aufgabe der Weiterbildenden. Mantra: „Teilnehmende abholen, wo sie stehen“
Creators: name: Beywl, Wolfgang
Publisher: name: ZIEL
Year: 2020
Subjects: Weiterbildung
Teilnehmer abholen
Teilnehmerorientierung
Lebensweltbezug
Erfahrungsorientierung
Teilnehmendenorientierung
Praxis
Qualitätssicherung
Teilnehmendenorientierung als Prozess
neue Lösungen finden
Teilnehmende abholen

description: Die 1970er Jahre waren die Hochzeit der „Teilnehmerorientierung“. Sie war Gegenbegriff zu einer Weiterbildung mit strikten Vorgaben zu Zielen und Inhalten, Frontalunterricht, einem rigiden Zeitregime oder einem engen Methodenrepertoire. Sie entstand parallel zu einem in soziale Bewegungen eingebetteten Verständnis von Weiterbildung, in der die Differenz zwischen Teilnehmenden und Leitenden aufgehoben werden sollte.
Histological morphology related to angiogenesis and hypoxia in congenital vascular malformations : exploring aetio-pathology and future target therapy
Creators: name: Maftei, Nonica
Publisher: name: Imperial College London
Year: 2012

description: Background Musculoskeletal arteriovenous malformations (AVMs) result from abnormal angiogenesis and belong to congenital vascular malformations (CVMs) group. AVMs persist and have associated morbidity and even mortality. The aetio-pathogenesis of AVMs is unknown. This study analyses histological morphology and the immunohistological expression of specific angiogenesis and hypoxia markers in comparison with control tissues in patients with CVMs. CVM pO2 was further assessed. This work was performed to gain insight into possible mechanisms involved in aetio-pathogenesis of CVMs. Methods Thirty three consecutive CVMs and 10 control specimens were analysed morphologically using routine techniques, histochemical (H&E, Masson Trichrome, Elasic Von Gieson, Toluidine blue) and immunohistochemical (CD68, CD3, CD20, Factor VIII, actin 1-α, ki67 and S100). Further immunohistochemical studies analysed VEGF A, VEGFR-1, Tie-2, αV3 and αV5 integrins, HIF-1α and HIF-2α, CAIX. The neutral endopeptidase (NEP) was studied by immunostaining for CD10 on 38 CVMs. Intraoperative blood samples from CVMs were analysed for pO2. Results Macrophages (p<0.0001), mast cells (p<0.0001), vessel number (p=0.0004) and diameters (p=0.0005) were significantly higher in the CVMs compared to controls. The expression of all angiogenesis markers were significantly higher in CVMs comparing to controls. HIF-1α, HIF-2α and CD10 (p=0.0002) were over-expressed in CVMs. There was a positive correlation between HIF-2α expression and VEGF A (p=0.0001), VEGFR-1 (p=0.0043), Tie-2 (p=0.03), αVβ3 (p=0.029), αVβ5 (0.045), CD10 (p=0.0002) and inflammatory cells in CVMs. Comparisons of CVM and arterial blood pO2 were not significant (p=1). Discussion Inflammation and imbalance of angiogenic and hypoxia markers are implicated in CVM pathogenesis. HIF-2α may play a more important role in CVM pathgogenesis than HIF-1α. CVM blood has an arterial pattern in spite of expressing HIF. CD10 may be a potential marker for CVMs in biopsies. Molecular patterns and potential signalling pathways involved in CVM pathogenesis are implicated in this work. This enhanced clinico-pathological correlation should improve therapeutic options and efficacy.
Physiological dependency explains temperature differences in sensitivity towards chemical exposure
Creators: name: Rakel, Kim
name: Becker, Denis
name: Bussen, Dino
name: Classen, Silke
name: Preuss, Thomas
name: Strauss, Tido
name: Zenker, Armin
name: Gergs, André
Publisher: name: Springer
Year: 2022
Subjects: subject: 600 - Technik, Medizin, angewandte Wissenschaften

description: In chemical risk assessment, extrapolations from laboratory tests to more realistic conditions are essential to address the toxic effects of pesticides on individuals and populations under field conditions. To transfer toxicological laboratory tests to differing temperature conditions, or outdoor field scenarios, the consideration of temperature dependence is essential and increases realism. Special consideration is given to the impact of temperature on direct sensitivity of organisms to pesticides, for which there are only few modelling approaches available so far. We present a concept for applying physiological temperature dependencies to toxicokinetic–toxicodynamic (TKTD) parameters in the General Uniformed Threshold model of Survival (GUTS). To test this approach in an exemplary study, temperature dependencies from studies on the developmental rate of the mayfly Cloeon dipterum were applied to the parameters of a previously parameterised TKTD model of this species after exposure to imidacloprid. Using a physiologically derived temperature correction for the TKTD rate constants, model predictions for independently conducted toxicology experiments with temperature ranges between 7.8 and 26.4 °C were performed for validation. Our approach demonstrates the successful transfer of a physiological observed temperature dependency on toxicity parameters and survival patterns for Cloeon dipterum and imidacloprid as a case study.
The employment impact of Poland’s special economic zones policy
Creators: name: Jensen, Camilla
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: In 1994, Poland launched a special economic zones experiment to maintain employment structures outside the major cities. Using difference-in-difference estimations, this paper evaluates whether the policy has been successful in its primary objective, which is to sustain employment in gminas (communes) more likely to be negatively affected by the economic transition. A significant and positive effect of the policy on employment is documented, but with some negative spillovers at the policy level as zones start to spread rapidly. Accounting for covariates, timing, policy spillovers and reducing imbalance through matching, the average treatment effect for employment is estimated to be 60%.
title: Häufig eingesetzte Antibiotika bei der Pyelonephritis – Leitlinie und lokales Resistenzniveau. Analyse eines universitären Einzelzentrums
Creators: name: Spachmann, P. J.
name: Breyer, J.
name: Burger, M.
name: Schnabel, M. J.
name: Otto, W.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Ciprofloxacin (CIP) und Ceftriaxon (CTX) stellen nach Leitlinie (LL) Substanzen der 1. Wahl zur Behandlung der Pyelonephritis (PN) der Frau dar, Amoxicillin/Clavulansäure (AMC) und Piperacillin/Tazobactam (PTZ) der 2. Wahl. Cefuroxim (CEF) und Cotrimoxazol (COT) finden sich[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Magnetic Resonance Imaging of the Neonatal Cardiovascular System : Impact of Patent Ductus Arteriosus
Creators: name: Broadhouse, Kathryn Mary
Publisher: name: Imperial College London
Year: 2013

description: The incidence of premature birth is increasing in absolute number and as a proportion of all births around the world. Many pathologies seen in this cohort are related to abnormal blood supply. Fetal and premature cardiovascular systems differ greatly as to maintain adequate blood flow to the developing organs in the uterine and extra-uterine environments require very different circulations. Subsequently following preterm birth the immature cardiovascular system undergoes abrupt adaptations, often resulting in the prolonged patency of the fetal shunt, ductus arteriosus. The impact of a patent ductus arteriosus (PDA) is poorly understood. However it is thought that large ductal shunt volumes may result in congestive cardiac failure and systemic hypo-­‐perfusion. Cardiac MRI has contributed greatly to the understanding of many cardiovascular diseases and congenital defects in paediatric and adult patients. Translating these imaging techniques to assess the preterm cardiovascular system requires careful optimization due to their condition, size and significantly increased heart rate. The work presented in this thesis employs multiple functional CMR techniques to investigate the preterm cardiovascular system in the presence and absence of PDA and the resultant cardiac function. A novel technique utilizing PC MRI to quantify PDA shunt volume and its impact on flow distribution is presented. Despite large shunt volumes, systemic circulation remained within normal range, although slight reduction is detectable when assessed at group level. Subsequently the impact of PDA and associated increased work load on left ventricular dimensions and function was then investigated using SSFP imaging. Results indicated that cardiac function was maintained even in the presence of large shunt volumes. Finally 4D PC sequences were employed to evaluate pulse wave velocity and flow regime within the preterm aorta, demonstrating the feasibility of hemodynamic assessment in this cohort. The findings of these studies provide insight into the impact of PDA. The reliable measurement and assessment of preterm cardiovascular system provides the potential to improve the understanding of the development and effects of certain pathologies seen in this cohort.
Regional economic modelling through an embedded econometric–inter-industry framework
Creators: name: Ashkan Masouman
name: Harvie, Charles
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: After the incorporation of an inter-industry analysis into an econometric framework was pioneered 40 years ago, there has been a growing number of studies in the literature focused on applying such an integrated framework at the subnational level. Models in the literature apply different strategies and structures to merge input–output (IO) and econometric models. The objective of the merged framework is to capitalize on the merits of both IO and time-series models. This paper presents an attempt to apply an intersectoral demand variable (ISDV) technique to embed IO analysis into a time-series model to investigate the economy of Illawarra in New South Wales, Australia. The result is a dynamic intersectoral model that provides high accuracy in forecasting sectoral employment.
Patient and public involvement in the benefit-risk assessment of medicines and regulatory decision-making
Creators: name: Hockley, Kimberley
Publisher: name: Imperial College London
Year: 2013

description: Currently, regulators make marketing authorisation decisions based on the benefit-risk balance of a treatment with little input from patients and the public. The aims of this thesis are to apply systematic methods of benefit-risk assessment proposed for use in regulatory decision-making, and examine how they can incorporate patient and public involvement. These aims were met through the investigation of three case studies: efalizumab, rimonabant, and natalizumab. Efalizumab (indication: plaque psoriasis) was withdrawn from the market due to the occurrence of progressive multifocal leukoencephalopathy. I examined the feasibility of applying descriptive and quantitative frameworks to determine the benefit-risk balance of efalizumab, and evaluated where patient and public involvement can be applied in the decision-making process. Rimonabant (indication: overweight and obesity) was withdrawn from the market due to the occurrence of psychiatric disorders. I conducted a discrete choice experiment to elicit patient and public preferences regarding the benefits and risks of treatment, and developed a probabilistic analysis method to analyse the preference data and determine the benefit-risk balance of rimonabant. Natalizumab (indication: relapsing remitting multiple sclerosis) received authorisation, but the benefit-risk balance was reassessed due to the occurrence of progressive multifocal leukoencephalopathy. Authorisation was maintained with risk minimisation measures. I developed a framework to guide the application, reporting, and evaluation of patient and public involvement in benefit-risk assessment. I then tested the feasibility of the framework with protocols designed to elicit patient and public preferences on the benefits and risks of natalizumab. Based on the findings of these case studies, preferences can be elicited from patients and the public and used to determine the benefit-risk balance of a medicine. This thesis provides a methodological foundation to guide the application, reporting and evaluation of PPI in the benefit-risk assessment of medicines and improve the legitimacy, transparency, and quality of regulatory decision-making.
Additional file 1: of Bayesian variable selection for parametric survival model with applications to cancer omics data
Creators: name: Duan, Weiwei
name: Zhang, Ruyang
name: Zhao, Yang
name: Shen, Sipeng
name: Wei, Yongyue
name: Chen, Feng
name: Christiani, David
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Table S1. TPR, FPR and FDR in variable selection with 50 replications (Weibull distribution). Table S2. TPR, FPR and FDR in variable selection with 50 replications (Gamma distribution). Table S3. Computational time (minutes) for application in simulation trials. Table S4. The estimated effects of 14 SNPs by SurvEMVS and classical Weibull regression. Table S5. Demographic and clinical characteristics of STAD patients. Table S6. The estimated effects of gene expression levels selected by SurvEMVS and Cox LASSO with their counterparts in low dimension scenario (i.e., Weibull regession and Cox model, respectively). Figure S1. Pseudocode for implementation of SurvEMVS. Figure S2. Averaged estimated effect (black vertical lines) for each marker over 50 replications under Scenario 2. Figure S3. Averaged estimated effect (black vertical lines) for each marker over 50 replications under Scenario 3. Figure S4. Averaged estimated effect (black vertical lines) for each marker over 50 replications under Scenario 4. Figure S5. Averaged estimated effect (black vertical lines) for each marker over 50 replications under Scenario 5. Figure S6 Averaged estimated effect (black vertical lines) for each marker over 50 replications under Scenario 6. Figure S7. MSE of parameter estimation and AUC of prognosis prediction for Scenarios 3 and 4. Figure S8. MSE of parameter estimation and AUC of prognosis prediction for Scenarios 5 and 6. Figure S9. Kaplan-Meier survival curve of patients with high, moderate, and low risk. (DOCX 9932 kb)
Dinge, Stimmungen, Handlungen - Der Spaziergang als Konstellation
Creators: name: Schwander, Markus
Publisher: name: Schweizerische Fachgesellschaft für Kunstpädagogik (SFKP)
Year: 2019
Subjects: subject: Gehen
subject: Grenzgang
subject: Konstellation
subject: Künstlerische Forschung
subject: Landschaft
subject: Promenadologie
subject: Raum
subject: Spaziergang
subject: Wahrnehmung
subject: 700 - Künste und Unterhaltung
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Sowohl in künstlerischen Forschungsprojekten als auch im Unterricht werden Spaziergänge zur Untersuchung von Raumwahrnehmung genutzt. Das gemeinsame Gehen wird dabei als Konstellation betrachtet, um die Faktoren, die die Aktion bestimmen, zu erkennen und zu beeinflussen, also kollektives Handeln zu gestalten. Anhand künstlerischer Beispiele wird aufgezeigt, wie Raum und Wahrnehmung zusammenhängen und wie ihr Verhältnis immer wieder neu konstruiert wird.