383. Characterization of Symptoms of Nasal Disease in Relapsing Polychondritis Using Patient-Reported Data
Creators: name: Shubhasree Banerjee1
Publisher: name: Zenodo
Year: 2022
Subjects: Vasculitis
ANCA
Abstracts
Giant Cell Arthritis
MPA
GPA
EGPA
Takayasu
IgA vasculitis

description: <strong>Background</strong>: Nasal chondritis is a well-recognized manifestation of relapsing polychondritis (RP), occasionally leading to saddle nose deformity. Early symptoms of nasal chondritis, such as nose pain, are often overlooked. The objective of this study was to characterize nose pain and identify associated symptoms reported by patients with RP. <strong>Methods</strong>: Patients with self-reported RP were invited to participate in an online survey. Participants were asked questions about nose pain such as location, onset, duration, frequency, quality, diurnal variation, aggravating and alleviating factors, associated symptoms, and saddle nose deformity. Participants with physician-diagnosed RP, aged ≥ 18 years, and who meet McAdams diagnostic criteria were included in the study. Fisher’s exact test was used to compare clinical characteristics between patients with and without nose pain. <strong>Results:</strong> A total of 659 subjects were included, of which 484 (73%) were from the United States. The majority (n=548, 83%) identified themselves as Caucasians, and 574 (87%) were female. Mean age was 50 years (interquartile range = 41-58). Many patients (n=430, 65%) reported nose pain. The diagnosis of RP in patients with nose pain was mostly made by rheumatologists (313, 73%) and otolaryngologists (101, 23%). Compared to patients without nose pain, those with nose pain were more likely to report saddle nose deformity, audio vestibular symptoms, joint pain and swelling (Table 1). Treatment with prednisone was reported by 429 (99%) patients, of which 423 (99%) reported symptom relief with prednisone. In patients with nose pain (n=430), pain was described as stabbing (n=147, 34%), sharp (n=73, 17%), dull (n=73, 17%), or burning (n=46, 10%); a majority (n=313, 73%) reported at least two types of pain and 137 (32%) did not report a pain descriptor. Associated nasal pressure (n=150, 34%), tingling (n=119, 27%), or throbbing (n=61, 14%) was reported. Factors felt to aggravate nose pain were minimal trauma (n=240, 55%), stress (n=210, 48%), and cold exposure (n= 104, 24%); 50% reported more than one aggravating factor. A majority of patients (n=322, 75%) reported the pain lasted for ≥1day. Frequency of reported nasal symptoms were daily (n=65, 15%), weekly (n=73, 17%), monthly (n=83, 19%), and few times/year (n=109, 25%). Onset of pain was mostly reported as variable (n=127, 30%) or gradual (n=138, 32%). The location of nasal pain included bridge (n=252, 58%), sides (n=171, 39%), base (n=146, 34%), or tip (n=134, 31%), with 275 (64%) reporting pain in at least two locations. Many patients reported nose pain during the day (n=262, 60%), some reported nighttime pain (n=169, 39%) and/or pain during sleep (n=108, 25%). The most common symptoms associated with nose pain were redness, swelling, and congestion, each reported by 50% of patients. <strong>Conclusion:</strong> Most patients with RP report a wide range of symptoms of nasal disease. The most common nasal complaints are stabbing pain with associated redness, swelling and congestion that lasts longer than a day, pain involving the bridge of the nose and that is aggravated by minor trauma. Awareness of the complexity of symptoms of nasal disease in RP and a detailed assessment of nasal manifestations could be helpful to clinicians for establishing a diagnosis of RP and monitoring disease activity. <strong>Disclosures:</strong> none