cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nuclear energy density functional and the nuclear alpha decay
Creators: name: Lim, Yeunhwan
name: Oh, Yongseok
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The nuclear $α$ decay of heavy nuclei is investigated based on the nuclear energy density functional, which leads to the $α$ potential inside the parent nucleus in terms of the proton and neutron density profiles of the daughter nucleus. We use the Skyrme force model, Gogny force model, and relativistic mean field model to get the nucleon density profiles inside heavy nuclei. Once the nucleon density profiles are determined, the parameters of the nuclear $α$ potential are fitted to the observed $α$ decay half-lives of heavy nuclei. This approach is then applied to predict unknown $α$ decay half-lives of heavy nuclei. To estimate the $Q$ values of unobserved $α$ decays, we make use of the liquid droplet model.
description: 10 pages, REVTeX, revised version
Sonnenfleckenzeichnung Nr. 113.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.05.2004, 09:00, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52
Creators: name: Dewey, Morgan G.
name: Jiang, Guochun
name: Li, Dajiang
name: Margolis, David M.
name: Archin, Nancie M.
name: Chen, Xian
name: Wang, Li
name: Browne, Edward P.
name: Wong, Lilly M.
name: Tang, Yuyang
name: Falcinelli, Shane D.
Publisher: name: Elsevier
Year: 2021

description: The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurkat and U1 cell line models of latency, HIV latently infected primary CD4+ T cells and resting CD4+ T cells isolated from people living with HIV. Crotonylation upregulated the levels of the active p52 subunit of NF-κB following AZD5582. Biochemical analyses suggest that the ubiquitin E3 ligase TRIM27 is involved in enhanced p100 cleavage to p52. When TRIM27 was depleted, AZD5582-induced HIV latency reversal was reduced. TRIM27 small interfering RNA (siRNA) knockdown reduced both p100 and p52 levels without inhibiting p100 transcription, indicating that TRIM27 not only acts on p100 cleavage but also may impact p100/p52 stability. These observations reveal the complexity of HIV transcriptional machinery, particularly of NF-κB.
Globular cluster formation with multiple stellar populations: self-enrichment in fractal massive molecular clouds
Creators: name: Bekki, Kenji
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Internal chemical abundance spreads are one of fundamental properties of globular clusters (GCs) in the Galaxy. In order to understand the origin of such abundance spreads, we numerically investigate GC formation from massive molecular clouds (MCs) with fractal structures using our new hydrodynamical simulations with star formation and feedback effects of supernovae (SNe) and asymptotic giant branch (AGB) stars. We particularly investigate star formation from gas chemically contaminated by SNe and AGB stars within MCs with different initial conditions and environments. The principal results are as follows. GCs with multiple generation of stars can be formed from merging of hierarchical star cluster complexes that are developed from high-density regions of fractal MCs. Feedback effects of SNe and AGB stars can control the formation efficiencies of stars formed from original gas of MCs and from gas ejected from AGB stars. The simulated GCs have radial gradients of helium abundances within the central 3 pc. The original MC masses need to be as large as 10^7 Msun for a canonical initial stellar mass function (IMF) so that the final masses of stars formed from AGB ejecta can be 10^5 Msun. Since star formation from AGB ejecta is rather prolonged (10^8 yr), their formation can be strongly suppressed by SNe of the stars themselves. This result implies that the so-called mass budget problem is much more severe than ever thought in the self-enrichment scenario of GC formation. and thus that IMF for the second generation of stars should be `top-light'.
description: 21 pages, 13 figure, MNRAS in press. Animation for the formation of first generation of stars from a fractal molecular cloud is found at https://drive.google.com/file/d/0B5PiT98G6JJrU3hYWkVrQVlZMFU/view?usp=sharing Animation for the second generation is found at https://drive.google.com/file/d/0B5PiT98G6JJrWnZkOFZfdEVPV00/view?usp=sharing
Loop suppressed light fermion masses with $U(1)_R$ gauge symmetry
Creators: name: Nomura, Takaaki
name: Okada, Hiroshi
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a model with two Higgs doublet where quark and charged-lepton masses in the first and second families are induced at one-loop level, and neutrino masses are induced at the two-loop level. In our model we introduce an extra $U(1)_R$ gauge symmetry that plays a crucial role in achieving desired terms in no conflict with anomaly cancellation. We show the mechanism to generate fermion masses, the resultant mass matrices and Yukawa interactions in mass eigenstates, and discuss several interesting phenomenologies such as muon anomalous magnetic dipole moment and dark matter candidate that are arisen from this model.
description: 27 pages, 3 figures, 4 tables: version accepted for publication in Physical Review D
Accretion onto a noncommutative inspired Schwarzschild black hole
Creators: name: Paik, Biplab
name: Gangopadhyay, Sunandan
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we investigate the problem of ordinary baryonic matter accretion onto the noncommutative geometry inspired Schwarzschild black hole. The fundamental equations governing the spherically symmetric steady state matter accretion are deduced. These equations are seen to be modified due to the presence of noncommutativity. The matter accretion rate is computed and is found to increase rapidly with the increase in strength of the noncommutative parameter. The sonic radius reduces while the sound speed at the sonic point increases with the increase in the strength of noncommutativity. The profile of the thermal environment is finally investigated below the sonic radius and at the event horizon and is found to be affected by noncommutativity.
description: 16 pages Latex, submitted in journal, comments are welcome
Sonnenfleckenzeichnung Nr. 222.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.09.2004, 06:30, erstellt von Michele Bianda
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Effective field theory for dissipative fluids (II): classical limit, dynamical KMS symmetry and entropy current
Creators: name: Glorioso, Paolo
name: Crossley, Michael
name: Liu, Hong
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this paper we further develop the fluctuating hydrodynamics proposed in arXiv:1511.03646 in a number of ways. We first work out in detail the classical limit of the hydrodynamical action, which exhibits many simplifications. In particular, this enables a transparent formulation of the action in physical spacetime in the presence of arbitrary external fields. It also helps to clarify issues related to field redefinitions and frame choices. We then propose that the action is invariant under a $Z_2$ symmetry to which we refer as the dynamical KMS symmetry. The dynamical KMS symmetry is physically equivalent to the previously proposed local KMS condition in the classical limit, but is more convenient to implement and more general. It is applicable to any states in local equilibrium rather than just thermal density matrix perturbed by external background fields. Finally we elaborate the formulation for a conformal fluid, which contains some new features, and work out the explicit form of the entropy current to second order in derivatives for a neutral conformal fluid.
description: 49+8 pages, 1 figure. v2: references added, minor clarifications
Association of family history of schizophrenia and clinical outcomes in individuals with eating disorders
Creators: name: Lichtenstein, Paul
name: Larsson, Henrik
name: Bergen, Sarah E.
name: Zhang, Ruyue
name: Birgegård, Andreas
name: Kuja-Halkola, Ralf
name: Bulik, Cynthia M.
Publisher: name: Cambridge University Press (CUP)
Year: 2021

description: BACKGROUND: Familial co-aggregation studies of eating disorders (EDs) and schizophrenia reveal shared genetic and environment factors, yet their etiological and clinical relationship remains unclear. We evaluate the influence of schizophrenia family history on clinical outcomes of EDs.
METHODS: We conducted a cohort evaluation of the association between family history of schizophrenia and ED clinical features, psychiatric comorbidities, and somatic and mental health burden in individuals born in Sweden 1977-2003 with anorexia nervosa (AN) or other EDs (OED: bulimia nervosa, binge-eating disorder, and ED not otherwise specified).
RESULTS: Of 12 424 individuals with AN and 20 716 individuals with OED, 599 (4.8%) and 1118 (5.4%), respectively, had a family history of schizophrenia (in up to third-degree relatives). Among individuals with AN, schizophrenia in first-degree relatives was significantly associated with increased comorbid attention-deficit/hyperactivity disorder (ADHD) [HR(95% CI) 2.26 (1.27-3.99)], substance abuse disorder (SUD) [HR (95% CI) 1.93 (1.25-2.98)], and anxiety disorders [HR (95% CI) 1.47 (1.08-2.01)], but higher lowest illness-associated body mass index (BMI) [1.14 kg/m2, 95% CI (0.19-2.10)]. Schizophrenia in any relative (up to third-degree) in AN was significantly associated with higher somatic and mental health burden, but lower ED psychopathology scores [-0.29, 95% CI (-0.54 to -0.04)]. Schizophrenia in first-degree relatives in individuals with OED was significantly associated with increased comorbid ADHD, obsessive-compulsive disorder, SUD, anxiety disorders, somatic and mental health burden, and suicide attempts.
CONCLUSIONS: We observed different patterns of ED-related outcomes, psychiatric comorbidity, and illness burden in individuals with EDs with and without family histories of schizophrenia and provide new insights into the diverse manifestations of EDs.
Probing the interplay between surface and bulk states in the topological Kondo insulator SmB$_6$ through conductance fluctuation spectroscopy
Creators: name: Biswas, Sangram
name: Hatnean, M. Ciomaga
name: Balakrishnan, G.
name: Bid, Aveek
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present results of resistance fluctuation spectroscopy on single crystals of the predicted Kondo topological insulator material SmB$_6$. Our measurements show that at low temperatures, transport in this system takes place only through surface states. The measured noise in this temperature range arises due to Universal Conductance Fluctuations whose statistics was found to be consistent with theoretical predictions for that of two-dimensional systems in the Symplectic symmetry class. At higher temperatures, we find signatures of glassy dynamics and establish that the measured noise is caused by mobility fluctuations in the bulk. We find that, unlike the topological insulators of the dichalcogenide family, the noise in surface and bulk conduction channels in SmB$_6$ are completely uncorrelated. Our measurements establish that at sufficiently low temperatures, the bulk has no discernible contribution to electrical transport in SmB$_6$ making it an ideal platform for probing the physics of topological surface states.
description: 9 pages, 11 figures
Sonnenfleckenzeichnung Nr. 270.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.11.2004, 10:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 229.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.09.2004, 08:00, erstellt von Renzo Ramelli
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
title: Epigenetic variance in dopamine D2 receptor
title: a marker of IQ malleability?
titleType: Subtitle
Creators: name: Kaminski, Jakob A.
name: Schlagenhauf, Florian
name: Rapp, Michael
name: Awasthi, Swapnil
name: Ruggeri, Barbara
name: Deserno, Lorenz
name: Banaschewski, Tobias
name: Bokde, Arun L. W.
name: Bromberg, Uli
name: Büchel, Christian
name: Quinlan, Erin Burke
name: Desrivières, Sylvane
name: Flor, Herta
name: Frouin, Vincent
name: Garavan, Hugh
name: Gowland, Penny
name: Ittermann, Bernd
name: Martinot, Jean-Luc
name: Paillère Martinot, Marie-Laure
name: Nees, Frauke
name: Papadopoulos Orfanos, Dimitri
name: Paus, Tomáš
name: Poustka, Luise
name: Smolka, Michael N.
name: Fröhner, Juliane H.
name: Walter, Henrik
name: Whelan, Robert
name: Ripke, Stephan
name: Schumann, Gunter
name: Heinz, Andreas
name: The IMAGEN Consortium
Publisher: name: Universität Potsdam
Year: 2020

description: Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 950
Entropy of black hole in the infinite-derivative gravity
Creators: name: Myung, Yun Soo
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We compute the Wald entropy of the Schwarzschild black hole in the ghost-free, infinite derivative gravity that is quadratic in curvature. This is not given purely by the area law but includes an additional contribution depending on the power of d'Alembertian operator, when requiring that the massless graviton be the only propagating mode in the Minkowski sapcetime.
description: 1+9 pages, no figures, version to appear in PRD
Sonnenfleckenzeichnung Nr. 190.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.08.2004, 10:15, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Application of an efficient generator-coordinate subspace-selection algorithm to neutrinoless double-β decay
Creators: name: Bally, B.
name: Romero, A. M.
name: Yao, J. M.
name: Engel, J.
name: Rodríguez, T. R.
Publisher: name: American Physical Society (APS)
Year: 2021

description: The generator coordinate method begins with the variational construction of a set of nonorthogonal mean-field states that span a subspace of the full many-body Hilbert space. These states are then often projected onto states with good quantum numbers to restore symmetries, leading to a set with members that can be similar to one another, and it is sometimes possible to reduce this set without greatly affecting results. Here, we propose a greedy algorithm that we call the energy-transition-orthogonality procedure (ENTROP) to select subsets of important states. As applied here, the approach selects on the basis of diagonal energy, orthogonality, and contribution to the matrix element that governs neutrinoless double-β decay. We present both shell-model and preliminary ab initio calculations of this matrix element for the decay of Ge76, with quadrupole deformation parameters and the isoscalar pairing strength as generator coordinates. ENTROP converges quickly, reducing significantly the number of basis states needed for an accurate calculation.
title: Optimal design of hydrometric station networks based on complex network analysis
Creators: name: Agarwal, Ankit
name: Marwan, Norbert
name: Maheswaran, Rathinasamy
name: Öztürk, Ugur
name: Kurths, Jürgen
name: Merz, Bruno
Publisher: name: Universität Potsdam
Year: 2020

description: Hydrometric networks play a vital role in providing information for decision-making in water resource management. They should be set up optimally to provide as much information as possible that is as accurate as possible and, at the same time, be cost-effective. Although the design of hydrometric networks is a well-identified problem in hydrometeorology and has received considerable attention, there is still scope for further advancement. In this study, we use complex network analysis, defined as a collection of nodes interconnected by links, to propose a new measure that identifies critical nodes of station networks. The approach can support the design and redesign of hydrometric station networks. The science of complex networks is a relatively young field and has gained significant momentum over the last few years in different areas such as brain networks, social networks, technological networks, or climate networks. The identification of influential nodes in complex networks is an important field of research. We propose a new node-ranking measure – the weighted degree–betweenness (WDB) measure – to evaluate the importance of nodes in a network. It is compared to previously proposed measures used on synthetic sample networks and then applied to a real-world rain gauge network comprising 1229 stations across Germany to demonstrate its applicability. The proposed measure is evaluated using the decline rate of the network efficiency and the kriging error. The results suggest that WDB effectively quantifies the importance of rain gauges, although the benefits of the method need to be investigated in more detail.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 951
Magnetism, transport, and thermodynamics in two-dimensional half-filled Hubbard superlattices
Creators: name: Mondaini, Rubem
name: Paiva, Thereza
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study magnetic, transport and thermodynamic properties of the half-filled two-dimensional ($2D$) Hubbard model with layered distributed repulsive interactions using unbiased finite temperature quantum Monte Carlo simulations. Antiferromagnetic long-ranged correlations at $T=0$ are confirmed by means of the magnetic structure factor and the onset of short-ranged ones is at a minimum temperature which can be obtained by peaks in susceptibility and specific heat following an RPA prediction. We also show that transport is affected in the large interaction limit and is enhanced in the non-repulsive layers suggesting a change of dimensionality induced by increased interactions. Lastly, we show that by adiabatically switching the interactions in layered distributed patterns reduces the overall temperature of the system with a potential application in cooling protocols in cold atoms systems.
description: 14 pages, 19 figures. Published version
Sonnenfleckenzeichnung Nr. 60.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.03.2004, 08:45, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
Creators: name: Petricoin, Emanuel F.
name: Bryant, Kirsten L.
name: Goodwin, Craig M.
name: Peterson, Jackson
name: Klomp, Jennifer E.
name: Kuo, Calvin J.
name: Li, Siqi
name: Ryan, Meagan B.
name: Pierobon, Mariaelena
name: Baldelli, Elisa
name: Neal, James T.
name: Counter, Christopher M.
name: Cox, Adrienne D.
name: McCormick, Aaron K.
name: Papke, Björn
name: Der, Channing J.
name: Klomp, Jeff A.
name: Smith, Amber R.
name: Yang, Runying
name: Drizyte-Miller, Kristina
name: Waters, Andrew M.
name: Lee, Ye S.
name: Yin, Hongwei H.
name: Diehl, J. Nathaniel
name: Stalnecker, Clint A.
name: DeLiberty, Jonathan M.
Publisher: name: Elsevier
Year: 2021

description: We apply genetic screens to delineate modulators of KRAS mutant pancreatic ductal adenocarcinoma (PDAC) sensitivity to ERK inhibitor treatment, and we identify components of the ATR-CHK1 DNA damage repair (DDR) pathway. Pharmacologic inhibition of CHK1 alone causes apoptotic growth suppression of both PDAC cell lines and organoids, which correlates with loss of MYC expression. CHK1 inhibition also activates ERK and AMPK and increases autophagy, providing a mechanistic basis for increased efficacy of concurrent CHK1 and ERK inhibition and/or autophagy inhibition with chloroquine. To assess how CHK1 inhibition-induced ERK activation promotes PDAC survival, we perform a CRISPR-Cas9 loss-of-function screen targeting direct/indirect ERK substrates and identify RIF1. A key component of non-homologous end joining repair, RIF1 suppression sensitizes PDAC cells to CHK1 inhibition-mediated apoptotic growth suppression. Furthermore, ERK inhibition alone decreases RIF1 expression and phenocopies RIF1 depletion. We conclude that concurrent DDR suppression enhances the efficacy of ERK and/or autophagy inhibitors in KRAS mutant PDAC.
Indistinguishability of bipartite states by positive-partial-transpose operations in the many-copy scenario
Creators: name: Li, Yinan
name: Wang, Xin
name: Duan, Runyao
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A bipartite subspace $S$ is called strongly positive-partial-transpose-unextendible (PPT-unextendible) if for every positive integer $k$, there is no PPT operator supporting on the orthogonal complement of $S^{\otimes k}$. We show that a subspace is strongly PPT-unextendible if it contains a PPT-definite operator (a positive semidefinite operator whose partial transpose is positive definite). Based on these, we are able to propose a simple criterion for verifying whether a set of bipartite orthogonal quantum states is indistinguishable by PPT operations in the many copy scenario. Utilizing this criterion, we further point out that any entangled pure state and its orthogonal complement cannot be distinguished by PPT operations in the many copy scenario. On the other hand, we investigate that the minimum dimension of strongly PPT-unextendible subspaces in an $m\otimes n$ system is $m+n-1$, which involves a generalization of the result that non-positive-partial-transpose (NPT) subspaces can be as large as any entangled subspace [N. Johnston, Phys. Rev. A 87: 064302 (2013)].
description: 6 pages, comments are welcome!
Guía de Cuidados Paliativos para Pacientes, Familiares y Cuidadores
Creators: name: Alves de Oliveira, João Batista
Publisher: name: Zenodo
Year: 2023
Subjects: Cuidados Paliativos; Calidad de Vida; Comprensión del Tratamiento; Guía de Información; Adhesión al Cuidado

description: Cada vez más, nos encontramos con pacientes que enfrentan enfermedades graves e incurables o que están cerca de la muerte, y requieren una atención diferenciada, que es la función de los Cuidados Paliativos. Sin embargo, es importante aclarar que los Cuidados Paliativos no deben entenderse como cuidados exclusivamente para quienes están muriendo, sino como cuidados destinados a aliviar el sufrimiento y mejorar la calidad de vida durante todo el proceso de la enfermedad, desde su inicio hasta su conclusión. Dado que los Cuidados Paliativos aún no son ampliamente aceptados debido a interpretaciones equivocadas, a menudo se los confunde con el abandono o incluso con la eutanasia, es esencial difundir su verdadera naturaleza. Dado que solo las personas debidamente informadas pueden adherirse o colaborar de manera efectiva en el tratamiento, surge la necesidad de desarrollar una guía que sirva como una fuente clara de información para pacientes, familiares y cuidadores. Esta guía no busca ser una más, sino ofrecer una nueva perspectiva sobre el tema, en especial alentando a los pacientes a ejercer su derecho a participar activamente en sus planes de tratamiento, en pos de una mejor calidad de vida. La estructura de la segunda parte en forma de preguntas y respuestas facilita la comprensión y la divulgación de la información, utilizando un lenguaje cercano al lector y proporcionando respuestas claras y objetivas. A medida que se difunda más información, habrá una mayor comprensión, menos dudas y una adhesión más sólida, lo que llevará a un mayor compromiso con el cuidado. Dado que la divulgación es el primer paso importante en la atención, la guía se presenta como una herramienta valiosa por sí sola.
description: Descargo de responsabilidad: La presente interpretación tiene como objetivo mejorar la claridad y comprensión de las ideas expresadas. No sustituye la orientación profesional, médica o legal de cada paciente. La información contenida en el texto no debe considerarse como asesoramiento médico, diagnóstico o tratamiento. Para obtener información precisa y relevante para sus necesidades individuales, se recomienda encarecidamente buscar la orientación de profesionales calificados y experimentados en las áreas pertinentes. No nos hacemos responsables de ninguna acción tomada en función del contenido de este texto.
TrustShadow: Secure Execution of Unmodified Applications with ARM TrustZone
Creators: name: Guan, Le
name: Liu, Peng
name: Xing, Xinyu
name: Ge, Xinyang
name: Zhang, Shengzhi
name: Yu, Meng
name: Jaeger, Trent
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cryptography and Security (cs.CR)
subject: Operating Systems (cs.OS)
subject: FOS: Computer and information sciences

description: The rapid evolution of Internet-of-Things (IoT) technologies has led to an emerging need to make it smarter. A variety of applications now run simultaneously on an ARM-based processor. For example, devices on the edge of the Internet are provided with higher horsepower to be entrusted with storing, processing and analyzing data collected from IoT devices. This significantly improves efficiency and reduces the amount of data that needs to be transported to the cloud for data processing, analysis and storage. However, commodity OSes are prone to compromise. Once they are exploited, attackers can access the data on these devices. Since the data stored and processed on the devices can be sensitive, left untackled, this is particularly disconcerting. In this paper, we propose a new system, TrustShadow that shields legacy applications from untrusted OSes. TrustShadow takes advantage of ARM TrustZone technology and partitions resources into the secure and normal worlds. In the secure world, TrustShadow constructs a trusted execution environment for security-critical applications. This trusted environment is maintained by a lightweight runtime system that coordinates the communication between applications and the ordinary OS running in the normal world. The runtime system does not provide system services itself. Rather, it forwards requests for system services to the ordinary OS, and verifies the correctness of the responses. To demonstrate the efficiency of this design, we prototyped TrustShadow on a real chip board with ARM TrustZone support, and evaluated its performance using both microbenchmarks and real-world applications. We showed TrustShadow introduces only negligible overhead to real-world applications.
description: MobiSys 2017
Estimates of Active Region Area Coverage through Simultaneous Measurements of He I $λλ$ 5876 and 10830 Lines
Creators: name: Andretta, V.
name: Giampapa, M. S.
name: Covino, E.
name: Reiners, A.
name: Beeck, B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Simultaneous, high-quality measurements of the neutral helium triplet features at 5876~Å and 10830~Å, respectively, in a sample of solar-type stars are presented. The observations were made with ESO telescopes at the La Silla Paranal Observatory under program ID 088.D-0028(A) and MPG Utility Run for FEROS 088.A-9029(A). The equivalent widths of these features combined with chromospheric models are utilized to infer the fractional area coverage, or filling factor, of magnetic regions outside of spots. We find that the majority of the sample is characterized by filling factors less than unity. However, discrepancies occur among the coolest K-type and warmest and most rapidly rotating F-type dwarf stars. We discuss these apparently anomalous results and find that in the case of K-type stars they are an artifact of the application of chromospheric models best suited to the Sun than to stars with significantly lower $T_\mathrm{eff}$. The case of the F-type rapid rotators can be explained with the measurement uncertainties of the equivalent widths, but they may also be due to a non-magnetic heating component in their atmospheres. With the exceptions noted above, preliminary results suggest that the average heating rates in the active regions are the same from one star to the other, differing in the spatially integrated, observed level of activity due to the area coverage. Hence, differences in activity in this sample are mainly due to the filling factor of active regions.
description: Accepted for publication in The Astrophysical Journal
Comorbidity between types of eating disorder and general medical conditions.
Creators: name: Bulik, Cynthia M
name: Plana-Ripoll, Oleguer
name: Momen, Natalie C
name: Yilmaz, Zeynep
name: Thornton, Laura M
name: McGrath, John J
name: Petersen, Liselotte Vogdrup
Publisher: name: Royal College of Psychiatrists
Year: 2021

description: BACKGROUND: Comorbidity with general medical conditions is common in individuals with eating disorders. Many previous studies do not evaluate types of eating disorder.
AIMS: To provide relative and absolute risks of bidirectional associations between (a) anorexia nervosa, bulimia nervosa and eating disorders not otherwise specified and (b) 12 general medical conditions.
METHOD: We included all people born in Denmark between 1977 and 2010. We collected information on eating disorders and considered the risk of subsequent medical conditions, using Cox proportional hazards regression. Absolute risks were calculated using competing risks survival analyses. We also considered risks for prior medical conditions and subsequent eating disorders.
RESULTS: An increased risk was seen for almost all disorder pairs (69 of 70). Hazard ratios for those with a prior eating disorder receiving a subsequent diagnosis of a medical condition ranged from 0.94 (95% CI 0.57-1.55) to 2.05 (95% CI 1.86-2.27). For those with a prior medical condition, hazard ratios for later eating disorders ranged from 1.35 (95% CI 1.26-1.45) to 1.98 (95% CI 1.71-2.28). Absolute risks for most later disorders were increased for persons with prior disorders, compared with reference groups.
CONCLUSIONS: This is the largest and most detailed examination of eating disorder-medical condition comorbidity. The findings indicate that medical condition comorbidity is increased among those with eating disorders and vice versa. Although there was some variation in comorbidity observed across eating disorder types, magnitudes of relative risks did not differ greatly.
Dynamical quantum phase transitions in the quantum Potts chain
Creators: name: Karrasch, C.
name: Schuricht, D.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We analyze the dynamics of the return amplitude following a sudden quench in the three-state quantum Potts chain. For quenches crossing the quantum critical point from the paramagnetic to the ferromagnetic phase, the corresponding rate function is non-analytic at critical times and behaves linearly in their vicinity. In particular, we find no indication of a link between the time evolution close to the critical times and the scaling properties of the quantum critical point in the Potts chain.
description: submitted to PRB
Evaluating disorders of gut‐brain interaction in eating disorders
Creators: name: Wiklund, Camilla A.
name: Bulik, Cynthia M.
name: Thornton, Laura M.
name: Kuja‐Halkola, Ralf
name: Rania, Marianna
Publisher: name: Wiley
Year: 2021

description: OBJECTIVE: Eating disorders commonly co-occur with gastrointestinal problems. This case-control study aimed to (a) document the prevalence of disorders of gut-brain interaction (DGBI) in eating disorders, (b) examine the specific impact of disordered eating behaviors on the risk of DGBI, and (c) explore the impact of current eating disorder psychopathology on DGBI.
METHOD: We included 765 cases with eating disorders and 1,240 controls. DGBI were assessed via the ROME III questionnaire. Prevalences of DGBI were calculated across eating disorder diagnoses (anorexia nervosa, bulimia nervosa, and multiple eating disorders) and in controls. The association between disordered eating behaviors and DGBI was examined using logistic regression models. Lastly, we compared the total number of DGBI in individuals with high versus low current eating disorder symptoms.
RESULTS: A large majority (88.2-95.5%) of individuals with eating disorders reported at least one DGBI and 34.8-48.7% reported three or more DGBI. Of the DGBI categories, functional bowel disorders were the most commonly endorsed category, and of the individual DGBI, irritable bowel syndrome was the most frequently reported (43.9-58.8%). All investigated disordered eating behaviors showed a positive association with most DGBI categories. Finally, individuals reporting high current eating disorder symptoms reported higher mean number of DGBI (3.03-3.34) than those with low current symptoms (1.60-1.84).
DISCUSSION: The directionality and mechanisms underlying the nature of the relationship between gastrointestinal and eating disorder symptoms is worthy of further study and clinicians should adopt an integrated approach by attending to both gastrointestinal and eating disorder symptoms in their patients.
Sonnenfleckenzeichnung Nr. 31.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.02.2004, 09:30, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 83.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.04.2004, 09:45, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2004

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Delayed Bet-Hedging Resilience Strategies Under Environmental Fluctuations
Creators: name: Ogura, Masaki
name: Wakaiki, Masashi
name: Rubin, Harvey
name: Preciado, Victor M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Dynamical Systems (math.DS)
subject: FOS: Biological sciences
subject: FOS: Mathematics

description: Many biological populations, such as bacterial colonies, have developed through evolution a protection mechanism, called bet-hedging, to increase their probability of survival under stressful environmental fluctutation. In this context, the concept of preadaptation refers to a common type of bet-hedging protection strategy in which a relatively small number of individuals in a population stochastically switch their phenotypes to a `dormant' metabolic state in which they increase their probability of survival against potential environmental shocks. Hence, if an environmental shock took place at some point in time, preadapted organisms would be better adapted to survive and proliferate once the shock is over. In many biological populations, the mechanisms of preadaptation and proliferation present delays whose influence in the fitness of the population are not well-understood. In this paper, we propose a rigorous mathematical framework to analyze the role of delays in both preadaptation and proliferation mechanisms in the survival of biological populations, with an emphasis on bacterial colonies. Our theoretical framework allows us to analytically quantify the average growth rate of a bet-hedging bacterial colony with stochastically delayed reactions with arbitrary precision. We verify the accuracy of the proposed method by numerical simulations and conclude that the growth rate of a bet-hedging population shows a non-trivial dependency on their preadaptation and proliferation delays. Contrary to the current belief, our results show that faster reactions do not, in general, increase the overall fitness of a biological population.
Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART® Molecules
Creators: name: Silvestri, Guido
name: Margolis, David M.
name: Nordstrom, Jeffrey L.
name: Haynes, Barton F.
name: Chahroudi, Ann
name: Jha, Shalini
name: Tuyishime, Marina
name: Faircloth, Katelyn
name: Dashti, Amir
name: Ferrari, Guido
Publisher: name: Frontiers
Year: 2021

description: Bispecific HIVxCD3 DART molecules that co-engage the viral envelope glycoprotein (Env) on HIV-1-infected cells and the CD3 receptor on CD3+ T cells are designed to mediate the cytolysis of HIV-1-infected, Env-expressing cells. Using a novel ex vivo system with cells from rhesus macaques (RMs) infected with a chimeric Simian-Human Immunodeficiency Virus (SHIV) CH505 and maintained on ART, we tested the ability of HIVxCD3 DART molecules to mediate elimination of in vitro-reactivated CD4+ T cells in the absence or presence of autologous CD8+ T cells. HIVxCD3 DART molecules with the anti-HIV-1 Env specificities of A32 or 7B2 (non-neutralizing antibodies) or PGT145 (broadly neutralizing antibody) were evaluated individually or combined. DART molecule-mediated antiviral activity increased significantly in the presence of autologous CD8+ T cells. In this ex vivo system, the PGT145 DART molecule was more active than the 7B2 DART molecule, which was more active than the A32 DART molecule. A triple combination of the DART molecules exceeded the activity of the individual PGT145 DART molecule. Modified quantitative virus outgrowth assays confirmed the ability of the DART molecules to redirect RM CD3+ T cells to eliminate SHIV-infected RM CD4+ T cells as demonstrated by the decreased propagation of in vitro infection by the infected cells pre-incubated with DART molecules in presence of effector CD8+ T cells. While mediating cytotoxic activity, DART molecules did not increase proinflammatory cytokine production. In summary, combination of HIVxCD3 DART molecules that have broadly-neutralizing and non-neutralizing anti-HIV-1 Env specificities can leverage the host immune system for treatment of HIV-1 infection but will require appropriate reactivation of the latent reservoir.
ByzRev 02.2020.007: Si Sheppard, Constantinople AD 717–18: The Crucible of History.
Creators: name: McMahon, Lucas R.
Publisher: name: The Byzantine Review
Year: 2020

description: Si Sheppard, Constantinople AD 717–18: The Crucible of History. Illustrated by Graham Turner. Oxford: Osprey Publishing Ltd 2020. 96 pp. -- ISBN: 978-1-4728-3692-2 (paperback: £15.99).
description: The Byzantine Review, Bd. 2 (2020)
Correlation plots of the Siberian radioheliograph
Creators: name: Lesovoi, Sergey
name: Kobets, Veronika
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Siberian Solar Radio Telescope is now being upgraded. The upgrading is aimed at providing the aperture synthesis imaging in the 4-8 GHz frequency range, instead of the single-frequency direct imaging due to the Earth rotation. The first phase of the upgrading is a 48-antenna array - the Siberian Radioheliograph. One type of radioheliograph data represents correlation plots. In evaluating the covariance of two-level signals, these plots are sums of complex correlations, obtained for different antenna pairs. Bearing in mind that correlation of signals from an antenna pair is related to a spatial frequency, we can say that each value of the plot is an integral over a spatial spectrum. Limits of the integration are defined by the task. Only high spatial frequencies are integrated to obtain dynamics of compact sources. The whole spectrum is integrated to reach maximum sensitivity. We show that the covariance of two-level variables up to Van Vleck correction is a correlation coefficient of these variables.