cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Modeling Smoking Induced Cardiac Dysfunction in 3D Microtissues
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco and nicotine-related harmful effects are major risk factors for premature cardiovascular diseases in both sexes around the world. Tobacco use is estimated to account for 7.2 million deaths in 2015 worldwide and approximately 480,000 per year in the United States alone. In addition to direct pulmonary damage caused by tobacco smoke, one of the main active ingredients, nicotine, affects the heart, liver and kidney due to its high concentration and residence in plasma. Approximately 10-15% of nicotine absorbed from a cigarette leads to tobacco-related systemic effects such as oxidative damage, inflammation and arrhythmogenesis, all of which promote progression toward heart failure. Heart tissues derived from smokers and non-smokers would serve as a useful surrogate to perform in vitro experiments to understand and define the pathogenic progression of tobacco-related cardiovascular disease. Because primary tissues are difficult to obtain and maintain in vitro, tissue engineered extracellular matrix (ECM)-based three-dimensional (3-D) tissue models that recapitulate cellular composition and microenvironment offer a promising alternative to assess functional abnormalities. The overall hypothesis of my TRDRP proposal is that 3-D extracellular matrix-based multicellular heart microtissues (MHMs) comprising human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs), endothelial cells (ECs), and cardiac fibroblast (CFs) can be utilized to model tobacco smoke induced cardiac dysfunction.
Phronima bowmani Shih
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima bowmani

description: Phronima bowmani Shih
Phronima bowmani Shih, 1991: 322, 327–328, figs 1a, 2a–h, 3a, 4a–h.
Type material
The holotype female, allotype male and four paratypes are in the USNM (Cat. No. 250351–53): in spirit.
Remarks
This species is very similar to P. colletti and P. bucephala (see Shih 1991). It seems to be restricted to the eastern tropical Pacific Ocean.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 15, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
Novel Pharmacotherapy Approaches in Smokers with Serious Mental Illness
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Persons with serious mental illness (SMI) such as bipolar disorder or schizophrenia smoke at rates 3 to 4 times higher than the general population and die decades earlier from tobacco-related diseases as a result. Despite having a 30-60% harder time quitting smoking and being more prone to experience mental health-related side effects than non-mentally ill (NMI) smokers when trying to quit using the 1st-line smoking cessation aids, SMI smokers are generally excluded in research trials testing newer treatment strategies that hold promise of possibly reducing side effects and boosting quit rates.
 The purpose of this proposal is to pilot test in persons with SMI new cessation strategies that have shown promise in NMI smokers. Specifically, we will test a new genetically-informed precision medicine technique called the nicotine metabolite ratio or “NMR” that determines how rapidly smokers break down nicotine. The NMR has been found to influence a smoker’s response to medication treatment. We will also test different ways to take the medication, varenicline, which has been found to be the most effective single medication available in SMI smokers to help them quit. We will determine whether these novel approaches reduce adverse mental health-related medication effects without compromising the medication’s effectiveness. Finally, we will combine the novel dosing strategies with a promising behavioral intervention called Acceptance and Commitment Therapy or “ACT” that teaches smokers to better accept the internal discomforts associated with a quit attempt to determine whether that, too, proves feasible and shows trends for improving medication tolerability and quit rates.
 The information obtained will shed light as to whether a genetically-influenced biomarker of nicotine clearance, the NMR, affects mental health-related side effect propensity in SMI smokers. It will improve the public health of California by availing this neglected subpopulation of smokers, who are disproportionately affected by tobacco-related disease and death, access to receive state-of-the-art smoking cessation treatment. This pilot feasibility trial is designed to obtain preliminary data for a larger, randomized controlled trial testing combined pharmacological and behavioral interventions that can be disseminated to real-world clinical settings throughout the State of California.
Phronima dunbari Shih
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima dunbari

description: Phronima dunbari Shih
Phronima dunbari Shih, 1991: 328–332, figs 5a, b, 6a–p.
Type material
The holotype female, allotype male and 18 paratypes are in the USNM (Cat. No. 250354–56): in spirit.
Remarks
This species is very similar to P. stebbingii (see Shih 1991). It is found in the eastern tropical Pacific Ocean ranging westward to about 150ºW.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 15, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
ТЕОРЕТИЧЕСКИЕ ОСНОВЫ ИННОВАЦИОННОГО ПРОЕКТИРОВАНИЯ В СТРОИТЕЛЬНОЙ ОТРАСЛИ
Creators: name: Кубаймуродов, Даврон
name: Искандаров, Э.Б.
name: Тулаганов, З.С.
Publisher: name: Zenodo
Year: 2025

description: В статье рассматривается внедрение инновационных решений в проектирование зданий и сооружений, акцентируя внимание на роли технологий и методов, способствующих повышению качества, устойчивости и экономической эффективности строительных процессов. Современные подходы к проектированию, включая использование Building Information Modeling (BIM), виртуальной (VR) и дополненной реальности (AR), представляют собой ключевые инструменты, позволяющие сократить сроки выполнения работ, минимизировать ошибки и оптимизировать ресурсы. Рассматриваются также аспекты экологической устойчивости и социального значения инновационного проектирования. В заключение подчеркивается, что адаптация к современным вызовам урбанизации и изменения климата требует постоянного внедрения новых технологий, что является необходимым условием для успешного развития строительной отрасли.
Disparities in Life Course Tobacco Exposure and Breast Cancer Risk
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Active smoking has been associated with an increased risk of breast cancer, however many studies have found conflicting results. Findings from the Nurse’s Health Study have shown that women who had ever smoked had a higher incidence of breast cancer compared to women who never smoked. Among premenopausal women, smoking was associated with an 11% increased risk of breast cancer for each additional 20 pack-years. It is unknown if these results, based largely on White professional women, apply to other racial/ethnic groups. Black women under age 40 are more likely to be diagnosed with breast cancer and have a higher rate of breast cancer related death compared to White women of the same age group. Furthermore, disparities in tobacco exposure, including age at initiation, years smoked, and secondhand exposure have been observed by race and socioeconomic status (SES). Yet, few studies have evaluated the association between smoking and breast cancer among premenopausal Black women.

 I aim to address this knowledge gap in our understanding of the role of tobacco smoking in relation to the etiology of breast cancer in young Black and White women by using data from the Young Women’s Health History Study, a case-control study of breast cancer conducted in Los Angeles County and Detroit (E. Velie, PI, 1R01CA136861-01A2). A total of 1,867 Non-Hispanic White and 1,362 Black women under age 50 (1,844 women with breast cancer and 1,385 women free of breast cancer) were interviewed about breast cancer risk factors, health behaviors, and health history. Extensive questions on tobacco exposure from cigarettes include prenatal exposure, personal tobacco use and secondhand exposure in childhood and adulthood.

 I propose to evaluate the association between tobacco exposure and breast cancer risk using multivariate logistic regression models controlling for known breast cancer risk factors. Differences by race and SES will be evaluated. All analyses will be conducted at the University of Southern California (USC) for my dissertation development and subsequent publications. Dr. Ann Hamilton, a cancer epidemiologist and Professor in the Department of Preventive Medicine at USC, will be my primary mentor. Additionally, experts in tobacco research, environmental toxins, statistics, and breast cancer pathology are on my dissertation committee and will be involved in my training.
Neuroimaging to detect brain network differences among heavy drinking smokers treated
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Heavy drinking smokers are a sizeable group of smokers who experience significant difficulties in quitting smoking and reducing drinking. Varenicline (VAR) and Naltrexone (NTX) are effective smoking cessation and drinking reduction aids, respectively. There is emerging evidence that a combination of Varenicline and Naltrexone (VAR+NTX) may be an effective smoking cessation treatment for heavy drinking smokers. No large clinical trials, however, have examined this combination medication.

 There is also little known about the neural effects of these medications. We will employ an advanced imaging technique, dynamic functional connectivity (dFC) analyses, to capture acute temporal changes in connectivity between brain networks. This helps overcome limitations of commonly used methods in neuroscience of addiction, which rely on averaged, static connectivity analyses. Recent work suggests that static connectivity of three brain networks called the salience (SN), default mode (DMN) and executive control (ECN) networks are predictive of cessation outcome. Little is known how predictions based on such static connectivity patterns compare to those based on dFC. Further, no studies have examined the potential effects of alcohol and smoking cessation medications on such dynamic predictive patterns. Examination of dFC may identify a neural signature of brain connectivity response to VAR and VAR+NTX.

 The proposed project will examine whether heavy drinking smokers assigned to VAR or VAR+NTX exhibit differences in brain connectivity, and whether such differences are predictive of smoking cessation. This proposal adds a functional magnetic resonance imaging component to an ongoing R01 clinical trial comparing effects of VAR versus VAR+NTX on smoking cessation milestones through 6-month post-quit. The proposed study will recruit 50 participants from this parent study for one imaging session to occur once target medication dose is reached. Analyses will compare the effects of medication conditions on dFC states, focusing on brain networks’ connectivity within the salience network, and test whether medication differences in dFC predict differences in cessation outcomes.
Phronimella Claus 1871
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronimella

description: Genus Phronimella Claus, 1871
Phronimella Claus, 1871: 149.
Anchylonyx Streets, 1877: 130.
Type species
Phronima elongata Claus, 1862. Type material could not be found at the ZMB or ZMH and is considered lost.
Diagnosis
Body and pereopods extremely slender. Pereonites 1 & 2 partly fused dorsally, not much deeper than following ones. Maxilliped with extremely reduced inner lobe, almost obsolete. Gnathopods 1 & 2 simple. Pereopod 5 with elongate carpus, only slightly widened distally, forming slender, imperfect subchela with propodus; anterior margin of basis to carpus dentate. Uropod 2 absent, or rudimentary in female; sometimes rudimentary in males, but usually with exopod and reduced endopod in mature specimens.
Monotypic.
Remarks
Phronimella makes ‘barrels’ from gelatinous plankton just like Phronima but the host species is not known (Laval 1980).
Phronimella is relatively common in the tropical regions of the world’s oceans and in the Mediterranean Sea.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 16, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
title: Courage, compassion, and connection: evaluation of an Indigenous-led health services research project in Labrador
Creators: name: McQuaid, Rebecca J.
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2025

description: A qualitative evaluation was conducted for the health services research project entitled Courage, Compassion, and Connection—The Journey to Healing: Exploring Cancer Pre-diagnosis for Indigenous Peoples in Labrador. The principle aim of the evaluation was to use the learnings from this Indigenous-led cancer care research project to make recommendations to inform and enhance future health services research with/in Labrador’s Indigenous communities. The Courage, Compassion, and Connection project is an important example of self-determination in health research, which the literature supports as integral to improving Indigenous health outcomes and equity. The present study used decolonizing research methodology consisting of a blend of Western and Indigenous evaluation approaches. Reflexive thematic analysis of data relating to project administration, community engagement, knowledge mobilization, and participant experience resulted in eight main themes. These were linked to five overarching recommendations (and specific sub-recommendations): (1) Ensure the project timeline allows for meaningful community engagement, (2) Focus on building strong relationships, (3) Develop an understanding of why community members may or may not engage in research, (4) Draw on community connections, knowledge, and experience, and (5) Prioritize accountability to the communities involved. Finally, the evaluation is also used to make a case for sufficient and sustainable funding for Indigenous-led health research in Canada.
EFFECTIVE METHODS OF TEACHING ENGLISH AT SCHOOL
Creators: name: Kamolova, Gulchehra
Publisher: name: Zenodo
Year: 2025

description: This article explores effective strategies for teaching English as a second language from a methodological perspective. It discusses various approaches, techniques, and tools that ESL teachers can utilize to enhance language learning outcomes. The paper emphasizes the importance of incorporating diverse methodologies to cater to the varied learning styles and needs of students. It highlights the role of communicative language teaching in promoting language proficiency and communicative competence. Additionally, the article discusses the integration of technology in instruction, emphasizing its potential to enhance engagement and facilitate language acquisition. Furthermore, it addresses the significance of cultural sensitivity and awareness in teaching, emphasizing the need for teachers to create inclusive and culturally responsive learning environments. Overall, this article provides valuable insights and practical recommendations for teachers seeking to enhance their teaching methodologies and improve the effectiveness of their language instruction.
CHANGES IN THE FIRE REGIME AND THE RELATIVE OF ROLE FUEL AND CLIMATE OF A HISTORICALLY FLAMMABILITY LIMITED WATERSHED IN THE WESTERN CASCADES AS IT RESPONDS TO TWO POSSIBLE FUTURE CLIMATE SCENARIOS
Creators: name: Gendron, Jonathan Morgan
Publisher: name: Washington State University
Year: 2022
Subjects: Earth systems modeling
Ecohydrology
Fire regime
RHESSys
Wildfire
Hydrologic sciences
Climate Change

description: Anthropogenic climate change has shifted forest fire regimes in the Pacific Northwest U.S by increasing wildfire frequency and area burned and the shift is projected to continue during the 21st century if temperature and summertime aridity continually increase. Such changes threaten natural resources in these systems, including drinking water reservoirs, which could see reduced water quality during post-fire recovery. Productive forests with historically flammability-limited wildfire regimes are suspectable to large-scale high-severity events because of large fuel sinks; therefore, as flammability increases with climate change, the frequency of these events is also expected to increase. However, it is unclear how climate change and wildfire will alter long-term fuel availability in these forests; if a strong fuel limitation develops, it could potentially offset increases in fuel flammability. Herein, we apply RHESSys-WMFire, a process-based ecohydrological framework coupled with a stochastic fire-spread model and a post-fire effects model, to explore the long-term coevolution of climate, vegetation, and wildfire in a historically climate-limited forest in the western cascades as it responds to two future climate scenarios: (1) one that enforces extreme fire-weather, and (2) one that is less arid and more suitable for forest production. Both scenarios feature three 525-year climate sequences to capture the co-evolution of vegetation and fire behavior for three stable climate regimes: the present, near future (2040s), and distant future (2070s). Each sequence was constructed from 30 years of climate data from existing CMIP5 GCM using a randomized climate resampling technique. We found both climate storylines forced a fuel limitation that increased during the 21st-century; however, increases in fuel flammability were greater, and resulted in increases in wildfire size, frequency, and area burned in near and distant future relative to the present. The severity of fuel limitation also corresponded with shifts in the fire-size distribution and the fire recurrence interval of different elevations, wherein strong fuel limitation caused relatively smaller fires and lower frequency. We surmise that reduced fuel availability will scale with the severity of climate forcing; however, in forests where fuel flammability is presently low, it will begin to limit wildfire behavior until a certain threshold has been reached.
Phronimella elongata
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronimella
Phronimella elongata

description: Phronimella elongata (Claus)
Phronima elongata Claus, 1862: 193–195, pl. 19, figs 2, 3 & 7.
Anchylonyx hamatus Streets, 1877: 131–132.
Phronimella filiformis Bovallius, 1887: 26.
Phronimella hippocephala Giles, 1887: 217–219, pl. 3, fig. 3.
Type material Type material of P. elongata is considered lost (see above).
Type material of synonyms
Type material of A. hamatus could not be found at the ANSP or USNM and is considered lost.
Type material of P. filiformis could not be found at the SMNH, ZMUC or Uppsala and is considered lost.
Type material of P. hippocephala could not be found at the BMNH and is considered lost.
Remarks
Phronimella is morphologically similar to Phronima, but the body is generally more slender, and the pereopods are much more slender and elongate. In addition, uropod 2 is reduced to a small pointed process in females and juvenile males. In adult males uropod 2 is usually present in a reduced form, with a relatively well­developed exopod, but a small, or obsolete endopod. Occasionally adult males have uropod 2 reduced as in females.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on pages 16-17, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
Rhinobatos Linck 1790
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Rajiformes
Rhinobatidae
Rhinobatos

description: Genus “ Rhinobatos ” Linck, 1790
Type species
Raja rhinobatos Linneaus, 1758, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 106, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
PHYSIO-ANATOMICAL AND ULTRASTRUCTURAL PERSPECTIVE OF RED BLOTCH --A RELATIVELY NEW VIRUS DISEASE OF GRAPEVINE (Vitis vinifera L.)
Creators: name: Hallwachs, Bailey
Publisher: name: Washington State University
Year: 2022

description: Red Blotch disease caused by Grapevine red blotch virus (GRBV) is a serious concern to grape growers and winemakers on the West Coast, including California, Oregon, and Washington. One crucial characteristic of all viruses, including Red Blotch, is the intimate association with cell components and anomalous structures following infection. Therefore, the objectives of this study were to investigate the fruit quality attributes and ultrastructure of various tissues and document the relationship between ultrastructural cytopathology and GRBV infection in ‘Pinot Noir’ employing various microscopy techniques from two vineyard locations in the Rogue Valley and Willamette AVAs in Oregon. The infected vines visually exhibited typical interveinal red blotches in the leaves with red-colored veins with flat leaf blade margins at the onset of berry ripening. The infected vines developed millerandage (large and small berries), with significantly lower fresh berry weight. Also, the infection significantly altered the primary and secondary metabolites desired for fermentation and the final composition of wine. Given that post-veraison berry development and ripening relies on phloem influx, the altered metabolism was indicative of a disruption of the phloem pathway. Transmission electron microscopy revealed that the sieve plates in the leaves and petiole were plugged with P protein, thereby inhibiting exporting of photosynthates out of the leaf. Consequently, there was a massive accumulation of starch granules in the chloroplast, which reflects depressed translocation. However, this did not affect the primary leaf anatomical organization in the infected vines. The starch accumulation grotesquely altered the chloroplast ultrastructure ranging from degradation of grana and stroma lamellae to complete dismantling of the chloroplasts, which corresponded to an increase in plastoglobuli and tannins in the cytoplasm. This study demonstrated that the normal metabolism of the grapevines relies on the structural integrity of the plant’s tissues.
Mechanistic basis of arrhythmogenic cardiac alternans following tobacco smoke exposure
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is known that smoking is associated with an increased incidence of abnormal heart rhythms (arrhythmias). Arrhythmias in the upper chambers of the heart (atrial fibrillation) increase risk for stroke, whereas arrhythmias in the lower chambers of the heart (ventricular tachycardia/fibrillation) pose great risk for sudden cardiac death. Therefore, understanding how and why smoking increases arrhythmia risk is of great clinical importance. We recently completed an experimental study in which we determined that mice exposed to secondhand tobacco smoke had increased susceptibility to cardiac arrhythmias, and we found that these arrhythmias were caused by abnormal calcium handling within heart cells. Tobacco smoke, however, contains many particles and chemicals and it is impossible to determine exactly which component of tobacco smoke may be contributing to abnormal calcium handling and arrhythmias. Therefore, the goal of this project is to test one chemical in tobacco smoke, nicotine, to determine if it is a contributor to arrhythmia. To do this, we will test the effects of acute nicotine application on rabbit hearts to determine its effect. We will also implant nicotine-releasing pumps in rabbits for one month to determine how long-term nicotine exposure might alter heart rhythms. The results of this study will be particularly important considering that nicotine is not only present in tobacco smoke, but also e-cigarettes, which are used by teenagers and young adults. Therefore, we hope to provide more detailed scientific information on the cardiac effects of nicotine.
title: Etica e giustizia nella Roma di Nanni Moretti
Creators: name: Riberi, Mario
Publisher: name: Italian Society for Law and Literature (ISLL)
Year: 2025

description: [Ethic and Justice in Nanni Moretti’s Rome] The essay examines the Rome described by Nanni Moretti in his films, a space from which spring the director’s reflections on ethics and justice from the mid-1970s until his last film, Il sol dell’avvenire (2023).
Phrosinidae Dana 1852
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phrosinidae

description: Family PHROSINIDAE Dana, 1852
Diagnosis
Body length 10–30 mm, rather compact with relatively thick cuticle, relatively transparent. Head large, globular, height more than length. Eyes large, occupying most of head surface. Pereonites all separate, or pereonites 1 & 2 fused. Coxae separate from pereonites. Antennae 1 reduced to two articles in females; multi­articulate, in males with enlarged callynophore, with aesthetasc brush composed of two asymmetrical fields located ventromedially and ventrolaterally. Antennae 2 rudimentary, or absent in females; multiarticulate in males. Mandibles with palp in males, without palp in females; molar welldeveloped. Maxillae 1 with palp and well­developed outer lobe, inner lobe absent. Maxillae 2 bilobed, well­developed. Maxilliped with slender outer lobes; inner lobe about halflength outer lobes. Gnathopods 1 & 2 simple. Pereopods 3–6 prehensile, or subchelate. Pereopod 5 the longest with large, denticulate subchela. Pereopods 5–7 with broad basis. Pereopod 7 reduced in size, sometimes with reduced number of articles. Uropods composed of single, foliaceous article. Telson small, not longer than half­length U3. Gills on pereonites 2–6. Oostegites on pereonites 2–5.
Three genera: Phrosina, Anchylomera and Primno.
Remarks
Species of this family are very distinctive, and are often present in plankton collections, sometimes in very large numbers. Phrosina and Anchylomera are monotypic, and Primno has been revised by Bowman (1978). Thus, only minimal additional information is provided here.
The structure of the uropods, each consisting of a single leaf­like article, is a unique feature amongst the Hyperiidea. They may serve as effective locomotory organs as phrosinids are known to be active swimmers, and sometimes occur in large swarms (Lobel & Randall 1986).
Key to the genera of the Family PHROSINIDAE
1. Pereopods 3 & 4 distinctly subchelate, with large teeth on distal margin of carpus. Pereopod 7 reduced to basis and one tiny additional article ......... Phrosina Risso, 1822
­ Pereopods 3 & 4 simple, or if subchelate, with very small teeth, or bristles on distal margin of carpus. Pereopod 7 reduced, with at least 2 articles in addition to basis...... 2
2. Pereopods 3 & 4 simple. Pereonites 1 & 2 separate .... Primno Guérin­Méneville, 1836
­ Pereopods 3 & 4 distinctly subchelate. Pereonites 1 & 2 fused ...................................... ................................................................................ Anchylomera Milne­Edwards, 1830
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on pages 17-18, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
D5.1 Focus Group Recommendations for AI Risk Predictions
Creators: name: Karvounis, Manos
Publisher: name: Zenodo
Year: 2023

description: This deliverable report presents a comprehensive account of our initial project phase for task T5.1 within the EFRA project. Our primary objective was to leverage our world-class advisory board's expertise to explore the unique challenges and generate relevant recommendations for adopting AI-enabled food risk predictions, particularly within the novel domain of privacy-preserving federated AI learning.

Our pursuit of high-quality recommendations led us to expand our original goal and engage in a more ambitious plan, consisting of two preparatory activities and a main event.

The first preparatory activity was a targeted focus group involving two expert advisory board members and an industry leader. The focus group, published as a webinar, centered on state-of-the-art predictive analytics for food safety and encouraged expert feedback on the presented predictions, their perceived validity and usefulness, and suggestions for future enhancement.

The second activity was an educational webinar aimed at the general public, designed to communicate the EFRA project's objectives and key innovations in a non-technical language.

The main event was the "1st International Summit on Privacy-preserving AI for Food Risk Intelligence," organized by Agroknow. The summit included keynote presentations and a discussion panel followed by smaller focus groups exploring the summit's theme in detail.

Our efforts culminated in numerous high-quality recommendations from experts across multiple domains, which will guide future EFRA work. The first activity also resulted in a pertinent white paper. Attendance statistics and public links to relevant content for all three events are included in this report.

Key achievements of this phase include a large set of expert recommendations for future EFRA work, successful public education about predictive analytics in food safety, organization of a large summit that brought together experts to discuss the privacy-preserving AI paradigm and engagement of representatives from multiple EU projects during the summit for collaborative work.
Functions of caspase-8 mutations in development of head and neck cancer and anti-tumor immunity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Head and neck squamous cell carcinoma (HNSCC) is a major health concern in the United States and worldwide. Nearly 1 out of every 10 cases of HNSCC has been found to have a mutation in a gene named caspase-8. The normal, nonmutated caspase-8 protein is known to play an important role in mediating cell death when cells are under stress. Additionally, caspase-8 plays a unique role in promoting the production of cytokines. These cytokines modulate the activity and production of immune cells and help the tumor cells escape elimination by our immune system. However, little is known about the role that HNSCC-associated caspase-8 gene mutations play in regulating anti-tumor immunity and how this mechanism impact tumorigenesis and progression of HNSCC. Three Aims are proposed here to determine whether caspase-8 gene mutations affect cytokine production and the destiny of immune cells in HNSCC tumors, and how these changes influence HNSCC initiation and progression.
 In Aim 1, I will study the roles of caspase-8 mutations in cell death and cytokine production in an in vitro cultured human cancer cell line, in which, normal caspase-8 (wild-type) will be modified to different mutant forms. In Aim 2, I will further determine how caspase-8 mutations impact cytokine production and modulate the production and activity of immune cells in mice inoculated with HNSCC cells expressing caspase-8 mutant proteins. In Aim 3, I will engineer a caspase-8 mutation into mice and determine the impact on development of HNSCC cancers in these mice following exposure to a chemical carcinogen similar to those found in tobacco smoke.
 Accomplishment of my project will allow me to determine whether the caspase-8 mutations frequently found in HNSCC play an important role in regulating anti-tumor immunity and HNSCC development. The ultimate goal for this study is to provide new diagnostic and prognostic markers to facilitate the development of new therapeutic strategies for patients with tobacco-associated HNSCC.
Optimization models for shape-constrained function estimation problems involving nonnegative polynomials and their restrictions
Creators: name: Papp, Dávid
Publisher: name: No Publisher Supplied
Year: 2011

description: In this thesis function estimation problems are considered that involve constraints on the shape of the estimator or some other underlying function. The function to be estimated is assumed to be continuous on an interval, and is approximated by a polynomial spline of given degree.    First the estimation of univariate functions is considered under constraints that can be represented by the nonnegativity of affine functionals of the estimated function. These include bound constraints,  monotonicity, and convexity constraints. A general framework is presented in which arbitrary combination of such constraints can be modeled and handled in a both theoretically and practically efficient manner, using semidefinite programming. The approach is illustrated by a variety of applications in statistical estimation. Numerical results are compared to those obtained using methods previously proposed in the statistical literature.    Next, multivariate problems are considered. Shape constraints that are tractable in the univariate case are intractable in the multivariate setting. Hence, instead of following the univariate approach, polyhedral and spectrahedral (semidefinite) approximations are proposed, which are obtained by replacing nonnegative splines by piecewise weighted-sum-of-squares polynomial splines. A decomposition method for solving very large scale multivariate problems is also investigated.    In order to include more constraints in the same unified framework, the notion of weighted-sum-of-squares functions is generalized to weighted-sum-of-squares cones in finite-dimensional real linear spaces endowed with a bilinear multiplication. It is shown that such cones are semidefinite representable, and the representation is explicitly constructed.    Finally, seeking a method to circumvent the use of semidefinite programming in the solution of optimization problems over nonnegative and weighted-sum-of-squares polynomials, we study the conditions of optimality, as well as barrier functions in such optimization problems. For univariate polynomials, a method based on fast Fourier transform is provided that accelerates the evaluation of the logarithmic barrier function (and its first two derivatives) of the moment cone. This reduces the running time of some interior point methods for semidefinite programming from O(n^6) to O(n^3) when solving problems involving polynomial nonnegativity constraints.
Analysis of cancer progression and morphology using computational modeling and image processing techniques
Creators: name: Norton, Kerri-Ann
Publisher: name: No Publisher Supplied
Year: 2011

description: In the US, an estimated 560,000 people died from cancer in the year 2009 (Jemal et al., 2009). The goal of this dissertation is to improve the fundamental understanding of cancer morphogenesis and so introduce scientific rigor into the diagnostic and prognostic methods used in the clinical setting. To this end, we focus on defining relationships between the history of growth of a cancerous lesion--which is what reliable prognosis depends on – and the morphology observed at an instant in time – which is what clinicians can observe ‐ through a combination of computational modeling and image processing. We achieve this goal by completing three aims. The first aim of the thesis is to examine the architectural progression of ductal carcinoma in situ of the breast (DCIS) using a two‐dimensional computational model. In this work we have found that the distinct architectural subtypes can result from different cellular features or from precancerous growths with similar cellular features but observed at different time points. The second aim of this thesis is to develop a border detection algorithm for skin lesions collected by dermoscopy. This work has resulted in the production of an automated and experimentally validated computational tool for the discrimination of melanoma, benign melanocytic lesions and non‐meanocytic lesions. The third and final aim is to characterize the fully three‐dimensional (3D) morphology of DCIS. In this work, we developed a 3D reconstruction approach to build 3D representations of DCIS. From this research, we have determined for the first time that there are two distinct 3D architectures of cribriform DCIS that are indistinguishable in 2D cross‐sections. Based on this finding, we propose that 3D reconstructions hold additional clinical information that cannot be accessed from analysis of 2D histological samples.
State mandated versus market-based locations of affordable housing
Creators: name: O'Connor, Stephen H.
Publisher: name: No Publisher Supplied
Year: 2011

description: This dissertation argues that despite massive public interventions at the federal and state levels, the private delivery of affordable housing in amounts sufficient to satisfy local demand is impossible to achieve. That the vast socio-economic differences within and between states has never been taken into account or incorporated into national housing policies. Instead, the distribution of finite housing resources has been skewed to a median statistic for nearly half a century, providing a majority of benefits to a narrow band of households earning between 50 and 80 percent of the Area Median Income (AMI).   That the national affordability standard fails to accommodate the great variation in both income and housing costs has left individual states to devise statutory schemes aimed at addressing challenges unique to their individual jurisdictions. The most celebrated is found in New Jersey, where the landmark Mount Laurel decisions were codified into legislation that in 1985 established the most progressive affordable housing process in the nation. Over the past quarter century, Mount Laurel has taught many lessons. Perhaps most important is that the adequate provision of affordable housing will never be accomplished where there is strong demand and high delivery costs. Similarly, attempts to overreach are met with considerable resistance, impeding the delivery of even modest amounts of affordable housing.   These lessons have helped to form the foundation of this research, where an assessment of the affordable housing produced in all fifty states is examined within the context of state mandated programs like Mount Laurel. To accomplish this objective required the use of both the 1990 and 2000 decennial censuses, where the output generated identifies both the least and most productive affordable housing states in the nation. These results are used to substantiate the conclusions drawn, which advocate for a new national housing affordability standard and more cogent public policies to ensure the equitable distribution of scarce housing resources.
Anoxypristis White & Moy-Thomas 1941
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Pristiformes
Pristidae
Anoxypristis

description: Genus Anoxypristis White & Moy-Thomas, 1941
Type species
Pristis cuspidatus Latham, 1794, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 108, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
МЕТОДИЧНЕ ЗАБЕЗПЕЧЕННЯ ВИЗНАЧЕННЯ ІННОВАЦІЙНОЇ ГНУЧКОСТІ ПІДПРИЄМСТВА ДЛЯ ЗАБЕЗПЕЧЕННЯ СПРИЙНЯТЛИВОСТІ БІЗНЕСУ ЩОДО НОВОВВЕДЕНЬ
Creators: name: Городницький, Р. О.
Publisher: name: Zenodo
Year: 2023
Subjects: інновації, інноваційний розвиток, активізація, інноваційна активність, підприємство, підприємництво, інноваційна сприйнятливість, інноваційна гнучкість.

description: Визначено склад факторів, що визначають суттєвість вимог щодо забезпечення чутливості підприємства щодо сприйняття нововведень та здійснення новаторської активності. Доведено, що основними причинами зростання значущості потреб бізнесу щодо підтримки інноваційної сприйнятливості є розмаїття змісту та нелінійність перебігу інноваційного процесу. Узагальнено змістовні характеристики методичних підходів щодо визначення інноваційної сприйнятливості підприємства, виділено складові оцінювання готовності бізнесу до впровадження нововведень. Встановлено економічну природу феномену інноваційної сприйнятливості бізнесу, що запропоновано розглядати як сформованість комплексу компетентностей (носіями яких виступають особи, різним чином задіяні в інноваційному процесі) щодо спроможності використання наявної техніко-технологічної та організаційно-економічної бази підприємства для забезпечення підвищення ефективності господарювання через впровадження нових форм та методів діяльності. Виявлено суттєві особливості, що характеризують процеси забезпечення інноваційної сприйнятливості бізнесу щодо нововведень, притаманні суб’єктам малого та середнього бізнесу. Обґрунтовано доцільність розгляду параметрів сприйнятливості бізнесу щодо нововведень через контекст формування інноваційної гнучкості підприємства, тобто спроможності щодо адаптації внутрішнього середовища суб’єкту господарювання до вимог щодо впровадження інновацій. Виявлено складові та запропоновано підхід щодо оцінювання інноваційної гнучкості.
Phronima curvipes Vosseler
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phronimidae
Phronima
Phronima curvipes

description: Phronima curvipes Vosseler
Phronima curvipes Vosseler, 1901: 27–29, pl. 3, figs 1–3.
Type material
Type material of P. curvipes could not be found at the ZMB or ZMH and is considered lost.
Remarks
Females of this species can resemble P. solitaria but are readily distinguished by the characteristic reversed ‘S’ curvature of the basis of pereopod 5, in lateral view. Males are similar to P. colletti and P. pacifica, but are distinguished by the details in the shape of pereopod 5, and by the reduced numbers of flagella articles of antennae 2 (7–9 versus 12– 13 for P. colletti and 15–17 for P. pacifica).
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 14, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734
INVESTIGATING THE EFFECTS OF A MECHANICAL AND CHEMICAL RECYCLING METHOD ON THE MATERIAL PROPERTIES OF A VIRGIN BOTTLE-GRADE POLY(ETHYLENE TEREPHTHALATE)
Creators: name: Hatt, Jonathan Patrick
Publisher: name: Washington State University
Year: 2022
Subjects: Chemical Recycling
Depolymerize
Glycolysis
Mechanical Recycling
PET
Thermal Degradation

description: Plastic is a material that has provided many benefits to society. Its use spans across many faucets of everyday life, from the electronics we use, to the vehicles that transport us to the packaging used to protect our food. The beginnings of its mass manufacture started without due consideration to the end-of-life plan for the material. Now, an excess volume of plastic waste exists, and the consequences have yet to be fully understood. Recycling has been introduced as a method to manage the plastic waste and has been developed into four main categories. Of these four, only mechanical recycling and chemical recycling have been designed to process this post-consumer waste into a feedstock for reuse, but their use are not without limitation. Mechanical recycling melt processes plastic by extrusion and returns the material directly to a pellet form, but the risk of degradation to the material is high. Chemical recycling depolymerizes a plastic into monomers and oligomers by the use of solvents, but requires either high energy loads or complex catalysts. This research investigates both recycling methods on a common recycled plastic, bottle-grade poly(ethylene terephthalate) (PET), to study their impacts on material property. First, the extent of degradation to the bottle-grade PET was studied over four iterations of melt processing by extrusion at 260°C. After each iteration, a decrease in the molecular weight of the plastic was measured, impacting the crystallinity, rheological and mechanical properties. Second, a bottle-grade PET was reacted in an extruder-like reactor with ethylene glycol and zinc acetate dihydrate to study depolymerization over two reaction temperatures and three reaction times. Within 8 minutes, at temperatures of 255°C and 185°C, 98% of the bottle-grade PET was depolymerized to low molecular weight oligomers. This corresponded to a decrease in melt temperature from 242°C to 162°C.
Phrosina Risso 1822
Creators: name: Zeidler, Wolfgang
Publisher: name: Zenodo
Year: 2004
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Phrosinidae
Phrosina

description: Genus Phrosina Risso, 1822
Phrosina Risso, 1822: 244.
Dactylocera Latreille, 1829: 117.
Type species
Phrosina semilunata Risso, 1822. Type material could not be found in any major European or north American museum and is considered lost.
Diagnosis
Body length up to 30 mm for females; males usually smaller; average size about 8 mm. Head produced into two sharp, triangular, rostral points. Pereonites 1 & 2 fused. Pereopods 3 & 4 subchelate, with large tooth­like carpal process. Pereopod 5 broader than any other pereopod; carpus with anterodistal margin armed with large tooth­like processes, forming folding hand with dactyl­like propodus which is longer than carpus; dactylus absent, or fused with propodus. Pereopod 6 similar to, but much smaller than, P5. Pereopod 7 reduced to broad basis and sometimes one additional, tiny article. Gills without folds.
Monotypic.
description: Published as part of Zeidler, Wolfgang, 2004, A review of the families and genera of the hyperiidean amphipod superfamily Phronimoidea Bowman & Gruner, 1973 (Crustacea: Amphipoda: Hyperiidea), pp. 1-66 in Zootaxa 567 on page 18, DOI: 10.11646/zootaxa.567.1.1, http://zenodo.org/record/5259734