cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates
Creators: name: Barbier, Claire
name: Wang, Yunfang
name: Yamauchi, Mitsuo
name: Reid, Lola M.
name: Moss, Nicholas
name: Yao, Hsin-Lei
name: Gerber, David
name: Cui, Cai-Bin
name: Costello, Martin J.
name: Sricholpech, Marnisa
name: Wauthier, Eliane
name: Loboa, Elizabeth G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Differentiation of embryonic or determined stem cell populations to adult liver fates under known conditions yields cells with some but not other adult-specific genes, aberrant regulation of one or more genes, and variation in the results from experiment to experiment. We tested the hypothesis that sets of signals produced by freshly isolated, lineage-dependent mesenchymal cell populations would yield greater efficiency and reproducibility in driving differentiation of human hepatic stem cells (hHpSCs) to adult liver fates. Subpopulations of liver-derived mesenchymal cells, purified by immunoselection technologies, included 1) angioblasts; 2) mature endothelia; 3) hepatic stellate cell precursors; 4) mature stellate cells (pericytes) and 5) myofibroblasts. Freshly immunoselected cells of each of these subpopulations were established in primary cultures under wholly defined (serum-free) conditions that we developed for short-term cultures and used them as feeders with hHpSCs. Feeders of angioblasts yielded self-replication; stellate cell precursors caused lineage restriction to hepatoblasts; mature endothelia produced differentiation to hepatocytes; and mature stellate cells and/or myofibroblasts resulted in differentiation to cholangiocytes. Paracrine signals, produced by the different feeders, were identified by biochemical, immunohistochemical, and qRT-PCR analyses and then those signals were used to replace the feeders in monolayer and 3-D cultures to elicit the desired biological responses from the hHpSCs. The defined paracrine signals proved able to yield reproducible responses from the hHpSCs and to permit differentiation to fully mature and functional parenchymal cells.
Additional file 1 of The complete genome sequence of the nitrile biocatalyst Rhodococcus rhodochrous ATCC BAA-870
Creators: name: Frederick, Joni
name: Fritha Hennessy
name: Horn, Uli
name: CortÃ©S, Pilar Torre
name: Broek, Marcel
name: Strych, Ulrich
name: Willson, Richard
name: Hefer, Charles
name: Jean-Marc Daran
name: Sewell, Trevor
name: Otten, Linda
name: Brady, Dean
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: SuppInfo Frederick et al. BAA-870 genome. Table S1. All sequenced Rhodococcus strains (353) according to the NCBI database (accessed 13/03/2019). Table S2. All complete sequenced Rhodococcus species ranked by release date according to the NCBI Genome database (accessed 11/03/2019). Table S3. Whole genome distance statistics between Rhodococcus rhodochrous ATCC BAA-870 and two closely matched strains. Table S4. Rhodococcus rhodochrous ATCC BAA-870 protein function breakdown based on BASys annotation COG classifications.
Black holes Entangled by Radiation
Creators: name: Liu, Yuxuan
name: Xian, Zhuo-Yu
name: Peng, Cheng
name: Ling, Yi
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct three models to describe the scenario where two eternal black holes are separated by a flat space, and can eventually be entangled by exchanging radiations. In the doubly holographic setup, we compute the entanglement entropy and the mutual information among the subsystems and obtain the dynamic phase structure of the entanglement. The formation of entanglement between the two black holes is delayed by the space where the radiations must travel through. Finally, if the two black holes exchange sufficient Hawking modes, the final state is characterized by a connected entanglement wedge; otherwise, the final entanglement wedge contains two separated islands. In the former case, the entanglement wedge of the two black holes forms at the time scale of the size of the flat space between them. While in both cases, unitarity of the evolution is preserved. When the sizes of two black holes are not equal, we observe a loss of entanglement between the smaller black hole and the radiation at late times. In the field theory side, we consider two Sachdev-Ye-Kitaev (SYK) clusters coupled to a Majorana chain, which resemble two black holes connected by a radiation region. We numerically compute the same entanglement measures, and obtain similar phase structures as the bulk results. In general, a time delay of the entanglement between the two SYK clusters is found in cases with a long Majorana chain. In particular, when the two SYK clusters are different in size, similar entanglement loss between the smaller SYK cluster and the Majorana chain is observed. Finally, we investigate a chain model composed of EPR clusters with particle exchanges between neighboring clusters, and reproduce the features of entanglement observed in the other models.
description: 38 pages, 16 figures; V2: references added, minor revision; V3: references added, minor revision; typo revision;
A Loop Reversibility and Subdiffusion of the Rotor-Router Walk
Creators: name: Papoyan, Vl. V.
name: Poghosyan, V. S.
name: Priezzhev, V. B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: The rotor-router model on a graph describes a discrete-time walk accompanied by the deterministic evolution of configurations of rotors randomly placed on vertices of the graph. We prove the following property: if at some moment of time, the rotors form a closed clockwise contour on the planar graph, then the clockwise rotations of rotors generate a walk which enters into the contour at some vertex $v$, performs a number of steps inside the contour so that the contour formed by rotors becomes anti-clockwise, and then leaves the contour at the same vertex $v$. This property generalizes the previously proved theorem for the case when the rotor configuration inside the contour is a cycle-rooted spanning tree, and all rotors inside the contour perform a full rotation. We use the proven property for an analysis of the sub-diffusive behavior of the rotor-router walk.
description: 15 pages, 5 figures
Calabi-Yau Threefolds Fibred by Mirror Quartic K3 Surfaces
Creators: name: Doran, Charles F.
name: Harder, Andrew
name: Novoseltsev, Andrey Y.
name: Thompson, Alan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14J32, 14J28, 14J30, 14D06

description: We study threefolds fibred by mirror quartic K3 surfaces. We begin by showing that any family of such K3 surfaces is completely determined by a map from the base of the family to the moduli space of mirror quartic K3 surfaces. This is then used to give a complete explicit description of all Calabi-Yau threefolds fibred by mirror quartic K3 surfaces. We conclude by studying the properties of such Calabi-Yau threefolds, including their Hodge numbers and deformation theory.
description: v2: Significant changes at the request of the referee. Section 3 has been rearranged to accommodate a revised proof of Proposition 3.5 (formerly 3.2). Section 5 has been removed completely, it will instead appear as part of Section 5 in arxiv:1601.08110
Polymerase γ Gene POLG determines the risk of sodium valproate-induced liver toxicity
Creators: name: Horvath, Rita
name: Stewart, Joanna D.
name: Baruffini, Enrico
name: Fontana, Robert J.
name: Watkins, Paul B.
name: Bulst, Stefanie
name: Chinnery, Patrick F.
name: Ferrero, Iliana
name: Day, Christopher P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Sodium valproate (VPA) is widely used throughout the world to treat epilepsy, migraine, chronic headache, bipolar disorder, and as adjuvant chemotherapy. VPA toxicity is an uncommon but potentially fatal cause of idiosyncratic liver injury. Rare mutations in POLG , which codes for the mitochondrial DNA polymerase Γ (polΓ), cause Alpers-Huttenlocher syndrome (AHS). AHS is a neurometabolic disorder associated with an increased risk of developing fatal VPA hepatotoxicity. We therefore set out to determine whether common genetic variants in POLG explain why some otherwise healthy individuals develop VPA hepatotoxicity. We carried out a prospective study of subjects enrolled in the Drug Induced Liver Injury Network (DILIN) from 2004 to 2008 through five US centers. POLG was sequenced and the functional consequences of VPA and novel POLG variants were evaluated in primary human cell lines and the yeast model system Saccharomyces cerevisiae . Heterozygous genetic variation in POLG was strongly associated with VPA-induced liver toxicity (odds ratio = 23.6, 95% confidence interval [CI] = 8.4-65.8, P = 5.1 × 10 −7 ). This was principally due to the p.Q1236H substitution which compromised polΓ function in yeast. Therapeutic doses of VPA inhibited human cellular proliferation and high doses caused nonapoptotic cell death, which was not mediated through mitochondrial DNA depletion, mutation, or a defect of fatty acid metabolism. Conclusion: These findings implicate impaired liver regeneration in VPA toxicity and show that prospective genetic testing of POLG will identify individuals at high risk of this potentially fatal consequence of treatment. (HEPATOLOGY 2010;52:1791-1796)
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk
Creators: name: Ma, Ling
name: L. Chuah, Marinee K.
name: Roncarolo, Maria Grazia
name: Samara-Kuko, Ermira
name: Nichols, Timothy C.
name: Genovese, Pietro
name: Cantore, Alessio
name: Goudy, Kevin
name: von Kalle, Christof
name: Mátrai, Janka
name: Damo, Martina
name: Schmidt, Manfred
name: VandenDriessche, Thierry
name: Annoni, Andrea
name: De Waele, Liesbeth
name: Arens, Anne
name: Wang, Wei
name: Acosta-Sanchez, Abel
name: Naldini, Luigi
name: Bartholomae, Cynthia C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Lentiviral vectors are attractive tools for liver-directed gene therapy because of their capacity for stable gene expression and the lack of preexisting immunity in most human subjects. However, the use of integrating vectors may raise some concerns about the potential risk of insertional mutagenesis. Here we investigated liver gene transfer by integrase-defective lentiviral vectors (IDLVs) containing an inactivating mutation in the integrase (D64V). Hepatocyte-targeted expression using IDLVs resulted in the sustained and robust induction of immune tolerance to both intracellular and secreted proteins, despite the reduced transgene expression levels in comparison with their integrase-competent vector counterparts. IDLV-mediated and hepatocyte-targeted coagulation factor IX (FIX) expression prevented the induction of neutralizing antibodies to FIX even after antigen rechallenge in hemophilia B mice and accounted for relatively prolonged therapeutic FIX expression levels. Upon the delivery of intracellular model antigens, hepatocyte-targeted IDLVs induced transgene-specific regulatory T cells that contributed to the observed immune tolerance. Deep sequencing of IDLV-transduced livers showed only rare genomic integrations that had no preference for gene coding regions and occurred mostly by a mechanism inconsistent with residual integrase activity. Conclusion: IDLVs provide an attractive platform for the tolerogenic expression of intracellular or secreted proteins in the liver with a substantially reduced risk of insertional mutagenesis. (hepatology 2011;)
Human hepatic stem cell and maturational liver lineage biology
Creators: name: Gaudio, Eugenio
name: Wauthier, Eliane
name: Turner, Rachael
name: Alpini, Gianfranco
name: Mendel, Gemma
name: Cardinale, Vincenzo
name: Alvaro, Domenico
name: Wang, Yunfang
name: Lozoya, Oswaldo
name: Reid, Lola M.
name: Barbier, Claire
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Livers are comprised of maturational lineages of cells beginning extrahepatically in the hepato-pancreatic common duct near the duodenum and intrahepatically in zone 1 by the portal triads. The extrahepatic stem cell niches are the peribiliary glands deep within the walls of the bile ducts; those intrahepatically are the canals of Hering in postnatal livers and that derive from ductal plates in fetal livers. Intrahepatically, there are at least 8 maturational lineage stages from the stem cells in zone 1 (periportal), through the midacinar region (zone 2), to the most mature cells and apoptotic cells found pericentrally in zone 3. Those found in the biliary tree are still being defined. Parenchymal cells are closely associated with lineages of mesenchymal cells, and their maturation is coordinated. Each lineage stage consists of parenchymal and mesenchymal cell partners distinguishable by their morphology, ploidy, antigens, biochemical traits, gene expression, and ability to divide. They are governed by changes in chromatin (e.g. methylation), gradients of paracrine signals (soluble factors and insoluble extracellular matrix components), mechanical forces, and feedback loop signals derived from late lineage cells. Feedback loop signals, secreted by late lineage stage cells into bile, flow back to the periportal area and regulate the stem cells and other early lineage stage cells, in mechanisms dictating the size of the liver mass. Recognition of maturational lineage biology and its regulation by these multiple mechanisms offers new understandings of liver biology, pathologies, and strategies for regenerative medicine.
Liver transplant recipient survival benefit with living donation in the MELD allocation era,,
Creators: name: Everhart, James E.
name: Fisher, Robert A.
name: Shearon, Tempie H.
name: Olthoff, Kim M.
name: Berg, Carl L.
name: Baker, Talia B.
name: Hayashi, Paul H.
name: Everson, Gregory T.
name: Merion, Robert M.
name: Terrault, Norah
name: Hong, Johnny C.
name: Brown, Robert S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Receipt of a living donor liver transplant (LDLT) has been associated with improved survival compared with waiting for a deceased donor liver transplant (DDLT). However, the survival benefit of liver transplant has been questioned for candidates with model for end-stage liver disease (MELD) scores< 15, and the survival advantage of LDLT has not been demonstrated during the MELD allocation era, especially for low MELD patients. Transplant candidates enrolled in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study after 02/28/02 were followed for a median of 4.6 years. Starting at the time of presentation of the first potential living donor, mortality for LDLT recipients was compared to mortality for patients who remained on the waiting list or received DDLT (no LDLT group) according to categories of MELD score (
Tensile strain-induced softening of iron at high temperature
Creators: name: Li, Xiaoqing
name: Schönecker, Stephan
name: Simon, Eszter
name: Bergqvist, Lars
name: Zhang, Hualei
name: Szunyogh, László
name: Zhao, Jijun
name: Johansson, Börje
name: Vitos, Levente
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: In weakly ferromagnetic materials, already small changes in the atomic configuration triggered by temperature or chemistry can alter the magnetic interactions responsible for the non-random atomic-spin orientation. Different magnetic states, in turn, can give rise to substantially different macroscopic properties. A classical example is iron, which exhibits a great variety of properties as one gradually removes the magnetic long-range order by raising the temperature towards and beyond its Curie point of $T_{\text{C}}^{0}=1043$\,K. Using first-principles theory, here we demonstrate that uniaxial tensile strain can also destabilize the magnetic order in iron and eventually lead to a ferromagnetic to paramagnetic transition at temperatures far below $T_{\text{C}}^{0}$. In consequence, the intrinsic strength of the ideal single-crystal body-centered cubic iron dramatically weakens above a critical temperature of $\sim 500$\,K. The discovered strain-induced magneto-mechanical softening provides a plausible atomic-level mechanism behind the observed drop of the measured strength of Fe whiskers around $300-500$\,K. Alloying additions which have the capability to partially restore the magnetic order in the strained Fe lattice, push the critical temperature for the strength-softening scenario towards the magnetic transition temperature of the undeformed lattice. This can result in a surprisingly large alloying-driven strengthening effect at high temperature as illustrated here in the case of Fe-Co alloy.
description: 3 figures
Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response
Creators: name: Aerssens, Jeroen
name: Darling, Jama M.
name: Fanning, Gregory
name: De Wit, Mieke
name: Shianna, Kevin V.
name: Afdhal, Nezam H.
name: Scholliers, Annick
name: Bollekens, Jacques
name: Fried, Michael W.
name: Goldstein, David B.
name: Thompson, Alexander J.
name: Howell, Charles D.
name: McHutchison, John G.
name: Hudson, Michael L.
name: Talloen, Willem
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Polymorphisms of IL28B gene are highly associated with sustained virological response (SVR) in patients with chronic hepatitis C treated with peginterferon and ribavirin. Quantitation of Interferon-γ Inducible Protein-10 (IP-10) may also differentiate antiviral response. We evaluated IP-10 levels in pretreatment serum from 115 non-responders and 157 sustained responders in the VIRAHEP-C cohort, including African Americans (AA) and Caucasian Americans (CA). Mean IP-10 was lower in sustained responders compared to non-responders (460 ± 37 pg/ml vs 697 ± 49 pg/ml, p<0.001), both in AA and CA. The positive predictive value of low IP-10 levels (<600 pg/ml) for SVR was 69% while the negative predictive value of high IP-10 levels (>600 pg/ml) was 67%. We assessed the combination of pretreatment IP-10 levels with IL28B genotype as predictors of treatment response. The IL28B polymorphism rs12979860 was tested in 210 participants. CC, CT, or TT genotypes were found in 30%, 49%, and 21%, respectively, with corresponding SVR rates of 87%, 50%, and 39% (p<0.0001). Serum IP-10 levels within the IL28B genotype groups provided additional information regarding the likelihood of SVR (p< 0.0001). CT carriers with low IP-10 had 64% SVR versus 24% with high IP-10. Similarly, a higher SVR rate was identified for TT and CC carriers with low versus high IP-10 (TT: 48% versus 20%, CC: 89% versus 79%). IL28B genotype and baseline IP-10 levels were additive but independent when predicting SVR in both AA and CA.
MOESM1 of The complete genome sequence of the nitrile biocatalyst Rhodocccus rhodochrous ATCC BAA-870
Creators: name: Frederick, Joni
name: Fritha Hennessy
name: Horn, Uli
name: CortÃ©S, Pilar Torre
name: Broek, Marcel
name: Strych, Ulrich
name: Willson, Richard
name: Hefer, Charles
name: Jean-Marc Daran
name: Sewell, Trevor
name: Otten, Linda
name: Brady, Dean
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: SuppInfo Frederick et al. BAA-870 genome. Table S1. All sequenced Rhodococcus strains (353) according to the NCBI database (accessed 13/03/2019). Table S2. All complete sequenced Rhodococcus species ranked by release date according to the NCBI Genome database (accessed 11/03/2019). Table S3. Whole genome distance statistics between Rhodococcus rhodochrous ATCC BAA-870 and two closely matched strains. Table S4. Rhodococcus rhodochrous ATCC BAA-870 protein function breakdown based on BASys annotation COG classifications.
MOSES Autonomous tugboat swarm operation: Operational scenarios, requirements, and architecture
Creators: name: Louzis, Konstantinos
Publisher: name: Zenodo
Year: 2022

description: The International Symposium on Reliability Engineering and Risk Management (ISRERM) is a bi-annual international conference on topics that cross several engineering and civil disciplines to advance the reliability engineering and risk management fields jointly with synergetic developments in applications. The 8th International Symposium on Reliability Engineering and Risk Management (ISRERM) was organized by the Institute for Risk and Reliability, Leibniz University Hannover, and supported by the European Safety and Reliability Association (ESRA), the Risk and Resilience Measurements Committee of the ASCE Infrastructure Resilience Division, the Safety Engineering & Risk Analysis Division of ASME (SERAD), the Liverpool Institute for Risk and Uncertainty, the International Joint Research Center for Engineering Reliability and Stochastic Mechanics (JCERSM), and the International Joint Research Center for Resilient Infrastructure (ICRI). The 8th edition of ISRERM was held in Hannover, Germany, on 4 – 7 September 2022. The objective of ISRERM 2022 was to provide an all-round inspiring environment and a multi-disciplinary forum for the exchange of knowledge and expertise on theories and methods in the field of Reliability Engineering and Risk Management, and on their application to a wide range of industrial and civil problem areas. Digital transformation has gathered pace in all industries and there are exciting opportunities for breaking completely new grounds in analysis such as machine learning, decision making such as human-machine collaborative decision making, and deployment using cyber-physical systems such as IoT. ISRERM 2022 served as a launch pad to bring reliability engineering and risk management to the next level. The 2020 pandemic has also brought greater urgency to develop societies in a sustainable and just way. Reliability engineering and risk management have a role to play in this large agenda, because it is increasingly important to ensure a safe and proper functionality of our technological and industrial systems, as a basis for further sustainable economic and societal development. The conference provided an academic and industrial platform to discuss challenges and solutions across various engineering disciplines, such as civil, mechanical, energy, aerospace and aeronautics, offshore and marine, and others. MOSES project was represented by NTUA, Mr. Konstantinos Louzis delivered a presentation on 06/09/2022, in session MS7 (Room 342) on ‘MOSES Autonomous tugboat swarm operation: Operational scenarios, requirements, and architecture‘.
Generic parabolic points are isolated in positive characteristic
Creators: name: Lindahl, Karl-Olof
name: Rivera-Letelier, Juan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We study analytic germs in one variable having a parabolic fixed point at the origin, over an ultrametric ground field of positive characteristic. It is conjectured that for such a germ the origin is isolated as a periodic point. Our main result is an affirmative solution of this conjecture in the case of a generic germ with a prescribed multiplier. The genericity condition is explicit: That the power series is minimally ramified, i.e., that the degree of the first non-linear term of each of its iterates is as small as possible. Our main technical result is a computation of the first significant terms of a minimally ramified power series. From this we obtain a lower bound for the norm of nonzero periodic points, from which we deduce our main result. As a by-product we give a new and self-contained proof of a characterization of minimally ramified power series in terms of the iterative residue.
description: Minor changes in the presentation. arXiv admin note: text overlap with arXiv:1311.4478
Attosecond Entangled Photons from Two-Photon Decay of Metastable Atoms: A Source for Attosecond Experiments and Beyond
Creators: name: Wang, Yimeng
name: Pandey, Siddhant
name: Greene, Chris H.
name: Shivaram, Niranjan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose the generation of attosecond entangled bi-photons in the extreme-ultraviolet regime by two-photon decay of a metastable atomic state as a source similar to spontaneous parametric down-conversion photons. The 1s2s $^1S_0$ metastable state in helium decays to the ground state by emission of two energy-time entangled photons with a photon bandwidth equal to the total energy spacing of 20.62 eV. This results in a pair correlation time in the attosecond regime making these entangled photons a highly suitable source for attosecond pump-probe experiments. The bi-photon generation rate from a direct four photon excitation of helium at 240 nm is calculated and used to assess some feasible schemes to generate these bi-photons. Possible applications of entangled bi-photons in attosecond time scale experiments, and a discussion of their potential to reach the zeptosecond regime are presented.
description: 6 pages, 3 figures, and supplementary material
Scholar-led Open Access in den Geistes- und Sozialwissenschaften: Akademische Selbstverwaltung, Kollaboration und Diversität in Publikationsprozessen
Creators: name: Kiesewetter, Rebekka
name: Steiner, Tobias
Publisher: name: Zenodo
Year: 2022
Subjects: scholar-led
publishing
Experimentation
Communities
Bibliodiversity
Pilot Project

description: “While the open access publishing model is certainly transformational, it is driven by experimenting with the new business, distribution, and permission models rather than with a new format of scholarly communication practice” (Mrva-Montoya, 2015, pp. 321-2). In gewissen Ausformungen steht scholar-led nicht nur für die akademische Selbstverwaltung und Öffnung von Publikationsinfrastrukturen, sondern auch von Forschungs- und Publikationspraxen. Eine solche Selbstverwaltung umfasst etwa die Nutzung und das Teilen von open source Tools und Plattformen, während eine praxisbezogene Öffnung beispielsweise in Richtung diverser Disziplinen, nicht-akademischen Partner_innen, anderer Forschungskulturen und Sprachen stattfinden kann. Wie wir in unserem Vortrag am Beispiel von Combinatorial Books: Gathering Flowers, einem multidisziplinären und mehrsprachigen Pilotprojekt im Rahmen des Forschungs-/Infrastrukturprojekts Community-led Open Publication Infrastructures for Monographs (COPIM), diskutieren möchten, verschiebt sich dadurch der Begriff von Zugänglichkeit – welcher in der Regel mit dem Zugang zu und der Verbreitung von Forschungsoutputs (hauptsächlich in Zeitschriften und Büchern) gleichgesetzt wird – hin zu den Produktionsmitteln und -prozessen der gemeinsamen Wissensproduktion und des Wissensaustauschs. Dies stellt Autor_innen, Editor_innen, Verlage und Programmierer_innen vor neue Aufgaben; verändert herkömmliche Publikationsprozesse und -praktiken (bspw. verwischen sich Grenzen zwischen Forschung, Schreiben, Redaktion und Veröffentlichung); wirkt sich auf die Beziehungen zwischen diversen Akteur_innen, aus denen sich konventionelle (OA) Publikationsprozesse konstituieren, aus (bspw. auf jene zwischen Verlagen, Autor_innen und Programmierer_innen); stellt etablierte Publikationsformate sowie (proprietäre) Werkzeuge und Technologien in Frage; und birgt Herausforderungen im Hinblick auf die längerfristige Archivierung von Publikationen.
 In diesem Vortrag führen wir in das Pilotprojekt ein und möchten dabei auf Fragen der Zusammenarbeit unter Berücksichtigung unterschiedlicher Forschungskulturen, disziplinärer und sprachlicher Unterschiede; über die Arbeitsabläufe, die ein solches Engagement auch in anderen Kontexten unterstützen können; und im Hinblick darauf, wie es sich in standardisierte oder etablierte Systeme für die Produktion, Verbreitung und Bewahrung von Print- und Onlinebüchern einfügen kann, eingehen.
description: Community-led Open Publishing Infrastructures for Monographs (COPIM) is supported by the Research England Development (RED) Fund, and Arcadia—a charitable fund of Lisbet Rausing and Peter Baldwin.
THE ROLE OF EDUCATION IN IMPROVING SOCIETY'S SPIRITUAL CAPACITY
Creators: name: Jabborova, Saodat
Publisher: name: Zenodo
Year: 2023

description: This article talks about the fact that the development of spiritual potential in society is an important factor that determines the future of the country. The author provides detailed information about the system of factors forming the spiritual potential of society. It is also highlighted that the spiritual potential of modern society changes and fills up under the influence of various factors.
Diplodia-Triebsterben der Kiefer; Waldschutz-Info Nr. 10/2008
Creators: name: Langer, Gitta Jutta
name: Bressem, Ulrich
name: Habermann, Michael
Publisher: name: Zenodo
Year: 2008
Subjects: Sphaeropsis sapinea, Diplodia sapinea, Diplodia-Triebsterben, Kieferntriebsterben

description: Der Wärme liebende Pilz Sphaeropsis sapinea (Synonym: Diplodia pinea) tritt seit einigen Jahren
 verstärkt in Kiefernbeständen im nord- und nordostdeutschen Raum (Sachsen-Anhalt, Niedersachsen)
 und in diesem Jahr auch zunehmend in Hessen auf. Er verursacht ein Triebsterben. Folgeschäden
 können eintreten, im ungünstigsten Falle auch das Absterben der Bäume. Der Erreger wurde auch schon
 an jüngeren Douglasien und an anderen Nadelbäumen gefunden. The warmth-loving fungus Sphaeropsis sapinea (synonym: Diplodia pinea) is becoming increasingly common in
 in pine stands in northern and northeastern Germany (Saxony-Anhalt, Lower Saxony) and this year increasingly in
 and this year increasingly in Hesse. It causes shoot dieback. Consequential damage
 can occur, in the worst case even the death of the trees. The pathogen has also been found
 on young Douglas firs and other conifers.
REF: A Rapid Exploration Framework for Deploying Autonomous MAVs in Unknown Environments
Creators: name: Patel, Akash
name: Lindqvist, Björn
name: Kanellakis, Christoforos
name: Agha-mohammadi, Ali-akbar
name: Nikolakopoulos, George
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Exploration and mapping of unknown environments is a fundamental task in applications for autonomous robots. In this article, we present a complete framework for deploying MAVs in autonomous exploration missions in unknown subterranean areas. The main motive of exploration algorithms is to depict the next best frontier for the robot such that new ground can be covered in a fast, safe yet efficient manner. The proposed framework uses a novel frontier selection method that also contributes to the safe navigation of autonomous robots in obstructed areas such as subterranean caves, mines, and urban areas. The framework presented in this work bifurcates the exploration problem in local and global exploration. The proposed exploration framework is also adaptable according to computational resources available onboard the robot which means the trade-off between the speed of exploration and the quality of the map can be made. Such capability allows the proposed framework to be deployed in a subterranean exploration, mapping as well as in fast search and rescue scenarios. The overall system is considered a low-complexity and baseline solution for navigation and object localization in tunnel-like environments. The performance of the proposed framework is evaluated in detailed simulation studies with comparisons made against a high-level exploration-planning framework developed for the DARPA Sub-T challenge as it will be presented in this article.
Multilinear transference of Fourier and Schur multipliers acting on non-commutative $L_p$-spaces
Creators: name: Caspers, Martijn
name: Krishnaswamy-Usha, Amudhan
name: Vos, Gerrit
Publisher: name: arXiv
Year: 2022
Subjects: subject: Functional Analysis (math.FA)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 22D25, 43A15, 46L51

description: Let $G$ be a locally compact unimodular group, and let $ϕ$ be some function of $n$ variables on $G$. To such a $ϕ$, one can associate a multilinear Fourier multiplier, which acts on some $n$-fold product of the non-commutative $L_p$-spaces of the group von Neumann algebra. One may also define an associated Schur multiplier, which acts on an $n$-fold product of Schatten classes $S_p(L_2(G))$. We generalize well-known transference results from the linear case to the multilinear case. In particular, we show that the so-called `multiplicatively bounded $(p_1,\ldots,p_n)$-norm' of a multilinear Schur multiplier is bounded above by the corresponding multiplicatively bounded norm of the Fourier multiplier, with equality whenever the group is amenable. Further, we prove that the bilinear Hilbert transform is not bounded as a vector valued map $L_{p_1}(\mathbb{R}, S_{p_1}) \times L_{p_2}(\mathbb{R}, S_{p_2}) \rightarrow L_{1}(\mathbb{R}, S_{1})$, whenever $p_1$ and $p_2$ are such that $\frac{1}{p_1} + \frac{1}{p_2} = 1$. A similar result holds for certain Calderón-Zygmund type operators. This is in contrast to the non-vector valued Euclidean case.
description: v3 incorporates reviewer comments and suggestions. To appear in the Canadian Journal of Mathematics
Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models
Creators: name: Thomas, Emmanuel
name: Liang, T. Jake
name: Li, Qisheng
name: Hu, Zongyi
name: Feld, Jordan J.
name: Fried, Michael W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The combination of pegylated interferon (PEG-IFN) and ribavirin is the standard treatment for chronic hepatitis C. Our recent clinical study suggests that ribavirin augments the induction of interferon-stimulated genes (ISGs) in patients treated for hepatitis C virus (HCV) infection. In order to further characterize the mechanisms of action of ribavirin, we examined the effect of ribavirin treatment on ISG induction in cell culture. In addition, the effect of ribavirin on infectious HCV cell culture systems was studied. Similar to interferon (IFN)-α, ribavirin potently inhibits JFH-1 infection of Huh7.5.1 cells in a dose-dependent manner, which spans the physiological concentration of ribavirin in vivo. Microarray analysis and subsequent quantitative polymerase chain reaction assays demonstrated that ribavirin treatment resulted in the induction of a distinct set of ISGs. These ISGs, including IFN regulatory factors 7 and 9, are known to play an important role in anti-HCV responses. When ribavirin is used in conjunction with IFN-α, induction of specific ISGs is synergistic when compared with either drug applied separately. Direct up-regulation of these antiviral genes by ribavirin is mediated by a novel mechanism different from those associated with IFN signaling and intracellular double-stranded RNA sensing pathways such as RIG-I and MDA5. RNA interference studies excluded the activation of the Toll-like receptor and nuclear factor κB pathways in the action of ribavirin.
title: Goliarda Sapienza. Uccidere la madre
Creators: name: Providenti , Giovanna
Publisher: name: Roma Tre-Press
Year: 2013

description: Il saggio si occupa dell'opera e delle vicende biografiche di Goliarda Sapienza (1924-1996), autrice di poesie, drammi teatrali, racconti e romanzi, precorritrice dei tempi e pensatrice autonoma. In particolare, il saggio si occupa del romanzo postumo L'arte della gioia, nel quale la protagonista uccide le tre donne che le fecero da madre.

description: B@belonline vol. 14/15 Filosofia e pratiche filosofiche
A coherent Ising machine for MAX-CUT problems : Performance evaluation against semidefinite programming relaxation and simulated annealing
Creators: name: Haribara, Yoshitaka
name: Utsunomiya, Shoko
name: Kawarabayashi, Ken-ichi
name: Yamamoto, Yoshihisa
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Combinatorial optimization problems are computationally hard in general, but they are ubiquitous in our modern life. A coherent Ising machine (CIM) based on a multiple-pulse degenerate optical parametric oscillator (DOPO) is an alternative approach to solve these problems by a specialized physical computing system. To evaluate its potential performance, computational experiments are performed on maximum cut (MAX-CUT) problems against traditional algorithms such as semidefinite programming relaxation of Goemans-Williamson and simulated annealing by Kirkpatrick, et al. The numerical results empirically suggest that the almost constant computation time is required to obtain the reasonably accurate solutions of MAX-CUT problems on a CIM with the number of vertices up to $2 \times 10^4$ and the number of edges up to $10^8$.
description: 10 pages, 9 figures; v5: typo in Table 1 (C_best of g22 is 0.9450)
The antiviral protein viperin inhibits HCV replication via interaction with NS5A
Creators: name: Beard, Michael R.
name: Fiches, Guillaume
name: Lemon, Stanley M.
name: Narayana, Sumudu
name: Jangra, Rohit K.
name: Li, Kui
name: Helbig, Karla J.
name: Yip, Evelyn
name: McCartney, Erin M.
name: Eyre, Nicholas S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The interferon-stimulated gene viperin has been shown to have antiviral activity against hepatitis C virus (HCV) in the context of the HCV replicon, although the molecular mechanisms responsible are not well understood. Here we demonstrate that viperin plays an integral part in the ability of interferon to limit replication of cell culture derived HCV (JFH-1) that accurately reflects the complete viral life cycle. Using confocal microscopy and Fluorescence Resonance Energy Transfer (FRET) analysis we demonstrate that viperin localizes and interacts with HCV NS5A at the lipid droplet interface. In addition viperin also associates with NS5A and the pro-viral cellular factor, VAP-A at the HCV replication complex. The ability of viperin to limit HCV replication was dependent on residues within the C-terminus as well as an N-terminal amphipathic helix. Removal of the amphipathic helix redirected viperin from the cytosolic face of the ER and the lipid droplet to a homogenous cytoplasmic distribution, coinciding with a loss of antiviral effect. C-terminal viperin mutants still localized to the lipid droplet interface and replication complexes but did not interact with NS5A proteins as determined by FRET analysis. In conclusion we propose that viperin interacts with NS5A and the host factor VAP-A to limit HCV replication at the replication complex. This highlights the complexity of host control of viral replication by interferon stimulated gene expression.
Adaptation of port call process for autonomous ship in a big port
Creators: name: Lopez, Jorge Miguel Lara
Publisher: name: Zenodo
Year: 2022

description: The 30th SMM took place on Hamburg’s exhibition campus from 6 to 9 September 2022. SMM delivers important stimuli to achieve this goal, said Knut Ørbeck-Nilssen, CEO of DNV Maritime, the main sponsor of the flagship fair: “SMM is one of the best events in the maritime calendar. It is truly global, and with its focus on innovation, it gives people an impression what the future of shipping will look like“. SMM was again accompanied by high-profile conferences covering specific topics such as digitalisation (Maritime Future Summit), ocean research (Offshore Dialogue), as well as security and defense (International Conference on Maritime Security & Defence). Sister projects AEGIS, AUTOSHIP & MOSES, along with ALICE, have jointly organised a seminar entitled ‘Reduced transportation cost and lower environmental impact by autonomy in ships and ports', which was conducted within the 30th edition of SMM, on September 7th, in Hamburg.
Many-Body electronic structure calculations of Eu doped ZnO
Creators: name: Lorke, M.
name: Frauenheim, T.
name: da Rosa, A. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The formation energies and electronic structure of europium doped zinc oxide has been determined using DFT and many-body $GW$ methods. In the absence of intrisic defects we find that the europium-$f$ states are located in the ZnO band gap with europium possessing a formal charge of 2+. On the other hand, the presence of intrinsic defects in ZnO allows intraband $f-f$ transitions otherwise forbidden in atomic europium. This result coorroborates with recently observed photoluminescence in the visible red region [1].
description: 9 pages, 13 Figures
Monoidally graded manifolds
Creators: name: Jiang, Shuhan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 58A50

description: We give a generalization of the theory of $\mathbb{Z}_2$-graded manifolds to a theory of $\mathcal{I}$-graded manifolds, where $\mathcal{I}$ is a commutative semi-ring with some additional properties. We prove Batchelor's theorem in this generalized setting. To our knowledge, such a proof is still missing except for some special cases.
description: 16 pages; to appear in J. Geom. Phys
Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis
Creators: name: Russo, Mark W.
name: Bonkovsky, Herbert L.
name: Schrum, Laura W.
name: Ghosh, Sriparna
name: McKillop, Iain H.
name: Li, Ting
name: Steuerwald, Nury M.
name: Walling, Tracy L.
name: Lakner, Ashley M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Hepatic stellate cell (HSC) activation is a pivotal event in initiation and progression of hepatic fibrosis and a major contributor to collagen deposition driven by transforming growth factor beta (TGFβ). microRNAs (miRs), small non-coding RNAs modulating mRNA and protein expression, have emerged as key regulatory molecules in chronic liver disease. We investigated differentially expressed miRs in quiescent and activated HSCs to identify novel regulators of profibrotic TGFβ signaling. miR microarray analysis was performed on quiescent and activated rat HSCs. Members of the miR-17-92 cluster (19a, 19b, 92a) were significantly down-regulated in activated HSCs. Since miR 19b showed the highest fold-change of the cluster members, activated HSCs were transfected with miR 19b mimic or negative control and TGFβ signaling and HSC activation assessed. miR 19b expression was determined in fibrotic rat and human liver specimens. miR 19b mimic negatively regulated TGFβ signaling components demonstrated by decreased TGFβ receptor II (TGFβRII) and SMAD3 expression. Computational prediction of miR 19b binding to the 3’UTR of TGFβRII was validated by luciferase reporter assay. Inhibition of TGFβ signaling by miR 19b was confirmed by decreased expression of type I collagen and by blocking TGFβ-induced expression of α1(I) and α2(I) procollagen mRNAs. miR 19b blunted the activated HSC phenotype by morphological assessment and decreased αSMA expression. Additionally, miR 19b expression was markedly diminished in fibrotic rat liver compared to normal liver; similarly, miR 19b expression was markedly down-regulated in fibrotic compared to normal human livers.
Magellan/IMACS spectroscopy of Grus I: A low metallicity ultra-faint dwarf galaxy
Creators: name: Chiti, Anirudh
name: Simon, Joshua D.
name: Frebel, Anna
name: Pace, Andrew B.
name: Ji, Alexander P.
name: Li, Ting S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a chemodynamical study of the Grus I ultra-faint dwarf galaxy (UFD) from medium-resolution ($R\sim11,000$) Magellan/IMACS spectra of its individual member stars. We identify eight confirmed members of Grus I, based on their low metallicities and coherent radial velocities, and four candidate members for which only velocities are derived. In contrast to previous work, we find that Grus I has a very low mean metallicity of $\langle$[Fe/H]$\rangle = -2.62 \pm 0.11$ dex, making it one of the most metal-poor UFDs. Grus I has a systemic radial velocity of $-143.5\pm1.2$ km s$^{-1}$ and a velocity dispersion of $σ_{\text{rv}} = 2.5^{+1.3}_{-0.8}$ km s$^{-1}$ which results in a dynamical mass of $M_{1/2} (r_h) = 8^{+12}_{-4} \times 10^5$ M$_{\odot}$ and a mass-to-light ratio of M/L$_V$ = $440^{+650}_{-250}$ M$_\odot$/L$_\odot$. Under the assumption of dynamical equilibrium, our analysis confirms that Grus I is a dark-matter-dominated UFD (M/L $> 80$ M$_\odot$/L$_\odot$). However, we do not resolve a metallicity dispersion ($σ_{\text{[Fe/H]}} < 0.44$ dex). Our results indicate that Grus I is a fairly typical UFD with parameters that agree with mass-metallicity and metallicity-luminosity trends for faint galaxies. This agreement suggests that Grus I has not lost an especially significant amount of mass from tidal encounters with the Milky Way, in line with its orbital parameters. Intriguingly, Grus I has among the lowest central density ($ρ_{1/2} \sim 3.5_{-2.1}^{+5.7} \times 10^7$ M$_\odot$ kpc$^{-3}$) of the UFDs that are not known to be tidally disrupting. Models of the formation and evolution of UFDs will need to explain the diversity of these central densities, in addition to any diversity in the outer regions of these relic galaxies.
description: 19 pages, 4 figures, 5 tables; published in ApJ