cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
miR-378a-3p promotes differentiation and inhibits proliferation of myoblasts by targeting HDAC4 in skeletal muscle development
Creators: name: Xuefeng Wei
name: Li, Hui
name: Zhang, Bowen
name: Caixia Li
name: Dong, Dong
name: Xianyong Lan
name: Yongzhen Huang
name: Yueyu Bai
name: Fengpeng Lin
name: Zhao, Xue
name: Chen, Hong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Muscle development, or myogenesis, is a highly regulated, complex process. A subset of microRNAs (miRNAs) have been identified as critical regulators of myogenesis. Recently, miR-378a was found to be involved in myogenesis, but the mechanism of how miR-378a regulates the proliferation and differentiation of myoblasts has not been determined. We found that miR-378a-3p expression in muscle was significantly higher than in other tissues, suggesting an important effect on muscle development. Overexpression of miR-378a-3p increased the expression of MyoD and MHC in C2C12 myoblasts both at the level of mRNA and protein, confirming that miR-378a-3p promoted muscle cell differentiation. The forced expression of miR-378a-3p promoted apoptosis of C2C12 cells as evidenced by CCK-8 assay and Annexin V-FITC/PI staining results. Through TargetScan, histone acetylation enzyme 4 (HDAC4) was identified as a potential target of miR-378a-3p. We confirmed targeting of HDAC4 by miR-378a-3p using a dual luciferase assay and western blotting. Our RNAi analysis results also showed that HDAC4 significantly promoted differentiation of C2C12 cells and inhibited cell survival through Bcl-2. Therefore, we conclude that miR-378a-3p regulates skeletal muscle growth and promotes the differentiation of myoblasts through the post-transcriptional down-regulation of HDAC4.
Safe Connectivity Maintenance for a Fleet of Underactuated Seaweed Farms in Dynamic Oceanic Environments
Creators: name: Hoischen, Nicolas
Publisher: name: ETH Zurich
Year: 2023
Subjects: Multi-agent systems
climate change
Flocking
Reachability analysis

description: Autonomous Multi-Agent Systems are increasingly being deployed in environments where winds and ocean currents can exert a significant influence on their dynamics. Recent work has developed powerful control policies for single agents that can leverage flows to achieve their objectives in dynamic environments. However, in the context of multi-agent systems, these flows can cause agents to collide or drift apart and lose direct inter-agent communications, especially when agents have low propulsion capabilities. To address these challenges, we propose a Hierarchical Multi-Agent Control approach that allows arbitrary single-agent performance policies that are unaware of other agents to be used in multi-agent systems, while ensuring safe operation.
We first develop a safety controller solely dedicated to avoiding collisions and maintaining inter-agent communication. Subsequently, we design a low-interference safe interaction (LISIC) policy that trades off the performance policy and the safety controller to ensure safe and optimal operation. Specifically, when the agents are at an appropriate distance, LISIC prioritizes the performance policy, while smoothly increasing the safety controller when necessary. We prove that under mild assumptions on the flows experienced by the agents, our approach can guarantee safety. Additionally, we demonstrate the effectiveness of our method in realistic settings through an extensive empirical analysis with underactuated Autonomous Surface Vehicles (ASV) operating in dynamical ocean currents where the assumptions do not always hold.
Oatlands Palace Excavations 1968. Interim Report
Creators: name: Cook, Alan
Publisher: name: Archaeology Data Service
Year: 2008

description: Surrey Archaeological Collections, 66, 1-9
description: TQ 07976516. Excavation was designed to obtain information on the form and development of the palace at Walton-on-Thames for comparison with other examples of Henry VIII's buildings for the History of the King's Works, volume III. Stripping of the northern part of the site revealed the following sequence: a timber building of early 15th century; a more substantial brick house of mid-15th century, on the same alignment; insertion at an oblique angle of a gate-house, c 1470; provision of a moat; blocking of the gatehouse; c 1537, razing of this part of the house and erection of a new range and gatehouse on a fresh alignment; c 1540, filling of the moat and its replacement by a culvert. Further work is planned on the moat bridges and on the relationship of the original 15th century house and the palace range. Large quantities of pottery, glass and tiles are reserved for later publication.
The Aretakis constants and instability in general spherically symmetric extremal black hole spacetimes: higher multipole modes, late-time tails, and geometrical meanings
Creators: name: Katagiri, Takuya
name: Kimura, Masashi
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study late-time behaviors of massive scalar fields in general static and spherically symmetric extremal black hole spacetimes in arbitrary dimensions. We show the existence of conserved quantities on the extremal black hole horizons for specific mass squared and multipole modes of the scalar fields. Those quantities on the horizon are called the Aretakis constants and are constructed from the higher-order derivatives of the fields. Focusing on the region near the horizon at late times, where is well approximated by the near-horizon geometry, we show that the leading behaviors of the fields are described by power-law tails. The late-time power-law tails lead to the Atetakis instability: blowups of the transverse derivatives of the fields on the horizon. We further argue that the Aretakis constants and instability correspond to respectively constants and blowups of components of covariant derivatives of the fields at the late time in the parallelly propagated null geodesic frame along the horizon. We finally discuss the relation between the Aretakis constants and ladder operators constructed from the approximate spacetime conformal symmetry near the extremal black hole horizons.
description: 32 pages; v2: minor revisions, accepted for publication in Phys. Rev. D
miR-378a-3p Promotes Differentiation and Inhibits Proliferation of Myoblasts by Targeting HDAC4 in Skeletal Muscle Development
Creators: name: Xuefeng Wei
name: Li, Hui
name: Zhang, Bowen
name: Caixia Li
name: Dong, Dong
name: Xianyong Lan
name: Yongzhen Huang
name: Yueyu Bai
name: Fengpeng Lin
name: Zhao, Xue
name: Chen, Hong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Muscle development, or myogenesis, is a highly regulated, complex process. A subset of microRNAs (miRNAs) have been identified as critical regulators of myogenesis. Recently, miR-378a was found to be involved in myogenesis, but the mechanism of how miR-378a regulates the proliferation and differentiation of myoblasts has not been determined. We found that miR-378a-3p expression in muscle was significantly higher than in other tissues, suggesting an important effect on muscle development. Overexpression of miR-378a-3p increased the expression of MyoD and MHC in C2C12 myoblasts both at the level of mRNA and protein, confirming that miR-378a-3p promoted muscle cell differentiation. The forced expression of miR-378a-3p promoted apoptosis of C2C12 cells as evidenced by CCK-8 assay and Annexin V-FITC/PI staining results. Through TargetScan, histone acetylation enzyme 4 (HDAC4) was identified as a potential target of miR-378a-3p. We confirmed targeting of HDAC4 by miR-378a-3p using a dual luciferase assay and western blotting. Our RNAi analysis results also showed that HDAC4 significantly promoted differentiation of C2C12 cells and inhibited cell survival through Bcl-2. Therefore, we conclude that miR-378a-3p regulates skeletal muscle growth and promotes the differentiation of myoblasts through the post-transcriptional down-regulation of HDAC4.
Bradysia Winnertz 1867
Creators: name: Heller, Kai
name: Hippa, Heikki
name: Vilkamaa, Pekka
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sciaridae
Bradysia

description: Genus Bradysia Winnertz, 1867
Bradysia Winnertz, 1867: 180.
Type-species: Bradysia angustipennis Winnertz, 1867, by subsequent designation of Enderlein (1911: 127, 183).
description: Published as part of Heller, Kai, Hippa, Heikki & Vilkamaa, Pekka, 2015, Taxonomy of Bradysia Winnertz (Diptera, Sciaridae) in the Northern Holarctic, with the description of four new species, pp. 1-15 in European Journal of Taxonomy 122 (122) on page 2, DOI: 10.5852/ejt.2015.122, http://zenodo.org/record/3780186
Insight into bio-methanol production and in silico elucidation of particulate methane monooxygenase enzyme from methanogens
Creators: name: Anand, Shreya
name: Shivankar, Kumudinee
Publisher: name: Zenodo
Year: 2024

description: The escalating environmental repercussions of fossil fuel combustion, particularly greenhouse gas emissions, in conjunction with the surging global energy demand, have spurred the quest for alternative energy sources. Methanol has emerged as a pivotal energy substitute due to its high octane rating and associated advantages such as diminished flammability, superior performance, and reduced emissions. Conventionally, bio-methanol production involves gasification and pyrolysis processes, with gasification yielding superior outcomes. To render gasification economically viable, an array of renewable inputs, encompassing biomass residues and byproducts from diverse sectors like biogas from landfills, wastewater, solid waste processing, black liquor from the pulp and paper domain, and glycerin, can be harnessed post-appropriate pretreatment to ensure heightened yield. The underlying mechanism for bio-methanol synthesis pivots on fermentation, leveraging the biotransformation prowess of prokaryotic proteobacteria methanotrophs to convert methane into methanol. This conversion is orchestrated by the enzyme methane monooxygenase (MMO), which exists in two distinct forms within methanotrophs: particulate (pMMO), associated with membranes, and soluble (sMMO). Despite their shared catalytic aptitude for methane-to-methanol oxidation, these enzymes exhibit dissimilarities in their amino acid sequences and metal cofactor requisites. Remarkably, both enzymes have independently evolved to address the same molecular challenge, coexisting within the same bacterial milieu. This study delves into the comprehensive elucidation of the particulate methane monooxygenase enzyme (EC 1.14.18.3) through an in silico approach. It encompasses enzyme characterization, estimation of physicochemical and functional attributes via tools like ProtParam and FASTA, determination of secondary structure using SOPMA, and execution of molecular docking through Swiss-Model and Swiss-Dock. For the docking analysis, two variants of pMMO were selected—Methylococcus capsulatus (Bath) [PDB ID: 1YEW/7t4o] and Methylosinus trichosporium OB3b [PDB ID: 3CHX]—with Zinc and Copper ions as ligands, shedding light on their roles as inducers or inhibitors for both enzyme forms.
Bound-state formation, dissociation and decays of darkonium with potential non-relativistic Yukawa theory for scalar and pseudoscalar mediators
Creators: name: Biondini, Simone
name: Shtabovenko, Vladyslav
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Dark matter models with light mediators featuring sizable interactions among dark particles enjoy an increasing attention in the model building community due to the elegance with which they can potentially explain the scaling relations governing galactic halos and clusters of galaxies. In the present work we continue our study of such models using non-relativistic and potential non-relativistic effective field theories (NREFTs and pNREFTs) and explore the properties of a Yukawa-type model with scalar and pseudoscalar interactions between a low-energetic scalar mediator and heavy dark matter fermions. In particular, we make first steps towards the formulation of such theories at finite temperature by providing the thermal bound-state formation rate and the thermal break-up of bound states from the self-energies of the dark-pair fields, that interact with the thermal environment. We estimate numerically bound-state effects on the dark matter energy density, that provide up to a $35\%$ correction depending on the relative size of the model couplings.
description: 47 pages, 11 figures, journal version, references added
A Bilingual Parallel Corpus with Discourse Annotations
Creators: name: Cotterell, Ryan
name: Jiang, Yuchen Eleanor
name: Liu, Tianyu
name: Ma, Shuming
name: Zhang, Dongdong
name: Sachan, Mrinmaya
name: Cotterell, Ryan
Publisher: name: ETH Zurich
Year: 2022

description: Machine translation (MT) has almost achieved human parity at sentence-level translation. In response, the MT community has, in part, shifted its focus to document-level translation. However, the development of document-level MT systems is hampered by the lack of parallel document corpora. This paper describes BWB, a large parallel corpus first introduced in Jiang et al. (2022), along with an annotated test set. The BWB corpus consists of Chinese novels translated by experts into English, and the annotated test set is designed to probe the ability of machine translation systems to model various discourse phenomena. Our resource is freely available, and we hope it will serve as a guide and inspiration for more work in document-level machine translation.
description: arXiv
When cold, dense quarks in 1+1 and 3+1 dimensions are not a Fermi liquid
Creators: name: Lajer, Marton
name: Konik, Robert M.
name: Pisarski, Robert D.
name: Tsvelik, Alexei M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We analyze the behavior of quarks coupled to a $SU(N_c)$ gauge theory in 1+1 dimensions. In the limit of strong coupling, the model reduces to a Wess-Zumino-Novikov-Witten (WZNW) model. At nonzero density, excitations near the Fermi surface form a non-Fermi liquid. With $N_f$ flavors, the finite density of quarks reduce to a free $U(1)$ field, which governs fluctuations in baryon number, together with a WZNW $SU(N_f)$ nonlinear sigma model at level $N_c$, from the pion/kaon modes. We compute the singularity in the charge susceptibility at the Fermi surface and the attendant power law correlations. We suggest that this is relevant to the quarkyonic regime of cold, dense QCD in 3+1 dimensions, in the limit that the Fermi surface is covered by many small patches, and the theory is effectively one dimensional. In this regime the dominant excitations near the Fermi surface are not baryons, but gapless bosonic modes.
Differential abilities of nitrogen dioxide and nitrite to nitrate proteins in thylakoid membranes isolated from Arabidopsis leaves
Creators: name: Takahashi, Misa
name: Shigeto, Jun
name: Shibata, Tatsuo
name: Sakamoto, Atsushi
name: Morikawa, Hiromichi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology
subject: 60506 Virology

description: Exposure of Arabidopsis leaves to nitrogen dioxide (NO2) results in nitration of specific chloroplast proteins. To determine whether NO2 itself and/or nitrite derived from NO2 can nitrate proteins, Arabidopsis thylakoid membranes were isolated and treated with NO2-bubbled or potassium nitrite (KNO2) buffer, followed by protein extraction, electrophoresis, and immunoblotting using an anti-3-nitrotyrosine (NT) antibody. NO2 concentrations in the NO2-bubbled buffer were calculated by numerically solving NO2 dissociation kinetic equations. The two buffers were adjusted to have identical nitrite concentrations. Both treatments yielded an NT-immunopositive band that LC/MS identified as PSBO1. The difference in the band intensity between the two treatments was designated nitration by NO2. Both NO2 and nitrite mediated nitration of proteins, and the nitration ability per unit NO2 concentration was ∼100-fold greater than that of nitrite.
Artificial neural network modelling of generalised parton distributions
Creators: name: Dutrieux, H.
name: Grocholski, O.
name: Moutarde, H.
name: Sznajder, P.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss the use of machine learning techniques in effectively nonparametric modelling of generalised parton distributions (GPDs) in view of their future extraction from experimental data. Current parameterisations of GPDs suffer from model dependency that lessens their impact on phenomenology and brings unknown systematics to the estimation of quantities like Mellin moments. The new strategy presented in this study allows to describe GPDs in a way fulfilling theory-driven constraints, keeping model dependency to a minimum. Getting a better grip on the control of systematic effects, our work will help the GPD phenomenology to achieve its maturity in the precision era commenced by the new generation of experiments.
description: 16 pages, 10 figures
Seventeenth-Century Delftware Potters in St Olave's Parish, Southwark
Creators: name: Davies, Isabel
Publisher: name: Archaeology Data Service
Year: 2008

description: Surrey Archaeological Collections, 66, 11-31
description: The first delftware potter in Southwark, Christian Wilhelm, settled in St Olave's parish there in 1604. At first a smalt-maker, he was forced to change his trade because of a rival's monopoly. He became a gallypot-maker about 1617, employing forty men in his pottery: in 1621 he received a monopoly patent. He died in 1630 and was succeeded by his son-in-law Thomas Townsend. The pot-making tradition thus established lasted through the 17th century under a succession of potters at the same site. Au (This documentary evidence relates to the excavated site at Potters Fields, near Pickleherring Stairs, Southwark, which produced quantities of waste from a 17th century delftware kiln. Ed.)
A global analysis of charmless two body hadronic decays for anti-triplet charmed baryons
Creators: name: Huang, Fei
name: Xing, Zhi-Peng
name: He, Xiao-Gang
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Recently Belle collaboration reported new measurements for the branching fractions with the first observing two processes of $\mathcal{B}(Ξ_c^0\toΛK^0_S)$, $\mathcal{B}(Ξ_c^0\toΣ^0 K^0_S)$ and updating data for $\mathcal{B}(Ξ_c^0\toΣ^+ K^-)$. Combined with other known data on charmless two body decays of anti-triplet charmed baryons, a lot of information can be derived with the assistance of $SU(3)$ flavour symmetry. Using $SU(3)$ relations between different decay modes, we can give some predictions based on the new measurements which can be tested with the high luminosity experiments in the future. More interestingly, we find that a global fit is now possible with the addition of new Belle data. In general, there are 18 complex $SU(3)$ invariant amplitudes. We find that a scenario of all amplitudes being real can fit the data well with a $χ^2/d.o.f$ only $0.773$. This indicates that neglecting the phases of the amplitudes is a reasonable assumption. When more data become available, one may be able to get more information for phases in the amplitudes. We give several comments on the feature of global fit regarding the branching fractions, relations between different decays, and decays involving $K^0$ and $\bar K^0$. Many of the unknown branching fractions and polarization asymmetry parameters of anti-triplet charmed baryon for charmless two body decays are predicted to be accessible by experiments at Belle, Belle~II, BES-III, and LHCb. The validity of $SU(3)$ for charmless two body hadronic decays can be more accurately tested.
description: 13 pages, 5 tables
Jahrbuch 2016. DARCH, ETH Zürich: Yearbook 2016. DARCH, ETH Zurich
Creators: name: Departement Architektur, ETH Zürich
Publisher: name: ETH Zurich
Year: 2016
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Teaching
subject: Research

description: ISBN:978-3-85676-358-9
Archaeology in Surrey 1992-3
Creators: name: Bird, David G
name: Crocker, Glenys M
name: Maloney, Catharine
name: Saich D, Dinah
Publisher: name: Archaeology Data Service
Year: 2002

description: Surrey Archaeological Collections, 83, 187-228
description: A review of recent fieldwork and chance finds in the administrative county of Surrey and the south-west London boroughs.
Raw High-Definition Radar for Multi-Task Learning
Creators: name: Rebut, Julien
name: Ouaknine, Arthur
name: Malik, Waqas
name: Pérez, Patrick
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: With their robustness to adverse weather conditions and ability to measure speeds, radar sensors have been part of the automotive landscape for more than two decades. Recent progress toward High Definition (HD) Imaging radar has driven the angular resolution below the degree, thus approaching laser scanning performance. However, the amount of data a HD radar delivers and the computational cost to estimate the angular positions remain a challenge. In this paper, we propose a novel HD radar sensing model, FFT-RadNet, that eliminates the overhead of computing the range-azimuth-Doppler 3D tensor, learning instead to recover angles from a range-Doppler spectrum. FFT-RadNet is trained both to detect vehicles and to segment free driving space. On both tasks, it competes with the most recent radar-based models while requiring less compute and memory. Also, we collected and annotated 2-hour worth of raw data from synchronized automotive-grade sensors (camera, laser, HD radar) in various environments (city street, highway, countryside road). This unique dataset, nick-named RADIal for "Radar, Lidar et al.", is available at https://github.com/valeoai/RADIal.
description: 12 pages, 7 figures, 6 tables
Time-Of-Flight methodologies with large-area diamond detectors for the effectively characterization of tens of MeV protons
Creators: name: Salvadori, M.
name: Andreoli, P. L.
name: Cipriani, M.
name: Cristofari, G.
name: De Angelis, R.
name: Malko, S.
name: Volpe, L.
name: Hernandez, J. A. Perez
name: Alpinaniz, J. I.
name: Morace, A.
name: Antici, P.
name: Migliorati, M.
name: Di Giorgio, G.
name: Consoli, F.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: A novel detector based on a polycrystalline diamond sensor is here employed in an advanced Time-Of-Flight scheme for the characterization of energetic ions accelerated during laser-matter interactions. The optimization of the detector and of the advanced TOF methodology allow to obtain signals characterized by high signal-to-noise ratio and high dynamic range even in the most challenging experimental environments, where the interaction of high-intensity laser pulses with matter leads to effective ion acceleration, but also to the generation of strong Electromagnetic Pulses (EMPs) with intensities up to the MV/m order. These are known to be a serious threat for the fielded diagnostic systems. In this paper we report on the measurement performed with the PW-class laser system Vega 3 at CLPU (30 J energy, 10^21 W/cm2 intensity, 30 fs pulses) irradiating solid targets, where both tens of MeV ions and intense EMP fields were generated. The data were analyzed to retrieve a calibrated proton spectrum and in particular we focus on the analysis of the most energetic portion (E > 5.8 MeV) of the spectrum showing a procedure to deal with the intrinsic lower sensitivity of the detector in the mentioned spectral-range.
An increased expression profile of Th9/IL-9 correlated with Th17/IL-17 in patients with immune thrombocytopenia
Creators: name: Jianlin Qiao
name: Xiaoqian Li
name: Yulu Wu
name: Xiaoqing Wu
name: Zhu, Feng
name: Liu, Na
name: Kunming Qi
name: Cheng, Hai
name: Depeng Li
name: Haiying Sun
name: Lingyu Zeng
name: Kailin Xu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th9 cells were recently identified as a new subtype of Th cells, characterized by preferential production of IL-9. Given the pleiotropic function of IL-9, Th9 cells are demonstrated to be involved in various autoimmune diseases. However, whether Th9 cells are involved in the pathogenesis of ITP remains unclear. In this study, 49 active ITP patients, 39 ITP with remission and 20 healthy controls were included. Peripheral blood mononuclear cells (PBMCs) were isolated from ITP and controls for measuring Th9 and Th17 cells by flow cytometry. Meanwhile, RNA was isolated from PBMCs for the measurement of the mRNA level of PU.1, IRF4, BATF, and RORγt by quantitative real-time PCR. Plasma levels of IL-9 and IL-17 were detected by ELISA. Our results showed that higher expressions of Th9, IL-9, and associated transcription factors (PU.1, IRF4, and BATF) were found in active ITP patients and restored to the normal level (except IL-9) in patients in remission. Meanwhile, Th9 cells and the IL-9 plasma level were positively correlated with Th17 cells and the IL-17 level in ITP patients, respectively. Moreover, a positive correlation of IRF4 or BATF with RORγt was found. In conclusion, an aberrant expression profile of Th9/IL-9 was associated with pathogenesis of ITP possibly through cooperatively working with Th17/IL-17 and therapeutically targeting Th9/IL-9 might be a novel approach in the treatment of ITP.
Study of neutron irradiation effects in Depleted CMOS detector structures
Creators: name: Mandić, I.
name: Cindro, V.
name: Debevc, J.
name: Gorišek, A.
name: Hiti, B.
name: Kramberger, G.
name: Skomina, P.
name: Zavrtanik, M.
name: Mikuž, M.
name: Vilella, E.
name: Zhang, C.
name: Powell, S.
name: Franks, M.
name: Marco-Hernandez, R.
name: Steininger, H.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this paper results of Edge-TCT and I-V measurements with passive test structures made in LFoundry 150 nm HV-CMOS process on p-type substrates with different initial resistivities ranging from 0.5 to 3 k$Ω$cm are presented. Samples were irradiated with reactor neutrons up to a fluence of 2$\cdot$10$^{15}$ n$_{\mathrm{eq}}$/cm$^2$. Depletion depth was measured with Edge-TCT. Effective space charge concentration $N_{\mathrm{eff}}$ was estimated from the dependence of depletion depth on bias voltage and studied as a function of neutron fluence. Dependence of $N_{\mathrm{eff}}$ on fluence changes with initial acceptor concentration in agreement with other measurements with p-type silicon. Long term accelerated annealing study of $N_{\mathrm{eff}}$ and detector current up to 1280 minutes at 60$^\circ$C was made. It was found that $N_{\mathrm{eff}}$ and current in reverse biased detector behaves as expected for irradiated silicon.
On the nature of valence charge and spin excitations via multi-orbital Hubbard models for infinite-layer nickelates
Creators: name: Been, Emily M.
name: Hsu, Kuan H.
name: Hu, Yi
name: Moritz, Brian
name: Cui, Yi
name: Jia, Chunjing
name: Devereaux, Thomas P.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Building upon the recent progress on the intriguing underlying physics for the newly discovered infinite-layer nickelates, in this article we review an examination of valence charge and spin excitations via multi-orbital Hubbard models as way to determine the fundamental building blocks for Hamiltonians that can describe the low energy properties of infinite-layer nickelates. We summarize key results from density-functional approaches, and apply them to the study of x-ray absorption to determine the valence ground states of infinite-layer nickelates in their parent form, and show that a fundamental $d^9$ configuration as in the cuprates is incompatible with a self-doped ground state having holes in both $d_{x^2-y^2}$ and a rare-earth-derived axial orbital. When doped, we determine that the rare-earth-derived orbitals empty and additional holes form low spin $(S=0)$ $d^8$ Ni states, which can be well-described as a doped single-band Hubbard model. Using exact diagonalization for a 2-orbital model involving Ni and rare earth orbitals, we find clear magnons at 1/2 filling that persist when doped, albeit with larger damping, and with a dependence on the precise orbital energy separation between the Ni- and rare-earth-derived orbitals. Taken together, a full two-band model for infinite-layer nickelates can well describe the valence charge and spin excitations observed experimentally.
Generalized Uncertainty Principle effects in the Hořava-Lifshitz quantum theory of gravity
Creators: name: Garcia-Compean, H.
name: Mata-Pacheco, D.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The Wheeler-DeWitt equation for a Kantowski-Sachs metric in Hořava-Lifshitz gravity with a set of coordinates in minisuperspace that obey a generalized uncertainty principle is studied. We first study the equation coming from a set of coordinates that obey the usual uncertainty principle and find analytic solutions in the infrared as well as a particular ultraviolet limit that allows us to find the solution found in Hořava-Lifshitz gravity with projectability and with detailed balance but now as an approximation of the theory without detailed balance. We then consider the coordinates that obey the generalized uncertainty principle by modifying the previous equation using the relations between both sets of coordinates. We describe two possible ways to obtain the Wheeler-DeWitt equation. One of them is useful to present the general equation but it is found to be very difficult to solve. Then we use the other proposal to study the limiting cases considered before, that is, the infrared limit that can be compared to the equation obtained by using general relativity and the particular ultraviolet limit. For the second limit we use a ultraviolet approximation and then solve analytically the resulting equation. We find that oscillatory behaviour is possible to be found but it is not a general feature for any values of the parameters involved.
description: 20 pages, 5 figures. A new Figure in Section 2 was included. Subsection added in Section 4. References added
Magnetically tunable Shubnikov-de Hass oscillations in MnBi2Te4
Creators: name: Lei, X.
name: Zhou, L.
name: Hao, Z. Y.
name: Liu, H. T.
name: Yang, S.
name: Sun, H. P.
name: Ma, X. Z.
name: Ma, C.
name: Lu, H. Z.
name: Mei, J. W.
name: Wang, J. N.
name: He, H. T.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Shubnikov-de Hass oscillations are directly observed in undoped antiferromagnetic topological insulator MnBi2Te4. With increasing magnetic fields, the oscillation period decreases gradually in the magnetic transition from canted antiferromagnetism to ferromagnetism and then saturates in high magnetic fields, indicating the field-induced evolution of the band structure. From the analysis of the high-field oscillations, a nontrivial Berry phase and a small effective mass are extracted, in agreement with the predicted Weyl semimetal phase in ferromagnetic MnBi2Te4. Furthermore, rotating the magnetization of MnBi2Te4 can lead to a splitting of the high-field oscillations, which suggests the enhanced asymmetry of the Weyl cones in tilted fields. Therefore, the observation of these magnetically tunable quantum oscillations clearly demonstrates the indispensable role of field in tuning the band structure or physical properties of MnBi2Te4.
description: 13 pages, 5 figures
Analytic Bootstrap in 2D Boundary Conformal Field Theory: Towards Braneworld Holography
Creators: name: Kusuki, Yuya
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recently, boundary conformal field theories (BCFTs) have attracted much attention in the context of quantum gravity. This is because a BCFT can be dual to gravity coupled to a heat bath CFT, known as the island model. On this background, it would be interesting to explore the duality between the boundary and the braneworld. However, this seems to be a challenging problem. The reason is because although there has been much study of rational BCFTs, there has been comparatively little study of irrational BCFTs, and irrational BCFTs are expected to be the boundary duals of the braneworlds. For this reason, we explore properties of boundary ingredients: the boundary primary spectrum, the boundary-boundary-boundary OPE coefficients and the bulk-boundary OPE coefficients. For this purpose, the conformal bootstrap is extremely useful. This is the first step in providing an understanding of BCFTs in the context of braneworld holography by using the conformal bootstrap. The techniques developed in this paper may be useful for further investigation of irrational BCFTs.
description: 38 pages, 3 figures, typos fixed and comments added
Approach to a holistic rider input determination for a dynamic motorcycle riding simulator
Creators: name: R. Pleß
name: S.Will
name: S. Guth
name: M. Hofmann
name: H. Winner
Publisher: name: figshare
Year: 2016
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 91106 Special Vehicles
subject: FOS: Environmental engineering

description: A proceedings paper from BMD 2016.
Bringing single track vehicle dynamics to motorcycle riding simulators - results of a pilot study
Creators: name: Will, Sebastian
name: R. Pleß
name: S. Guth
Publisher: name: figshare
Year: 2016
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 91106 Special Vehicles
subject: FOS: Environmental engineering

description: A proceedings paper from BMD 2016.
Hot Circumsingle Disks Drive Binary Black Hole Mergers in Active Galactic Nucleus Disks
Creators: name: Li, Ya-Ping
name: Dempsey, Adam M.
name: Li, Hui
name: Li, Shengtai
name: Li, Jiaru
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Binary black hole (BBH) mergers, particularly those with component masses in the pair-instability gap, may be produced by hierarchical mergers in the disks surrounding Active Galactic Nuclei (AGN). While the interaction of an embedded BBH with an AGN disk is typically assumed to facilitate a merger, recent high-resolution hydrodynamical simulations challenge this assumption. However, these simulations often have simplified treatments for the gas thermodynamics. In this work, we model the possible consequence of various feedback from an embedded BBH with a simple model that maintains an enhanced temperature profile around each binary component. We show that when the minidisks around each BH become hotter than the background by a factor of three, the BBH orbital evolution switches from expansion to contraction. By analyzing the gravitational torque profile, we find that this change in direction is driven by a weakening of the minidisk spirals and their positive torque on the binary. Our results highlight the important role of thermodynamics around BBHs and its effect on their orbital evolution, suggesting that AGN disks could be efficient factories for BBH mergers.
description: 11 pages, 5 figures, ApJL in press
title: Production of a Monoclonal Antibody Against Benzo[α]Pyrene Diol Epoxide DNA Adducts
Creators: name: Austin, Brian Peden
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2002

description: Benzo[α]pyrene is a ubiquitous pollutant produced from the incomplete combustion of organic material such as fossil fuels. It is found in the workplace, urban air, drinking water, and the food supply. Recently, it has been proposed that benzo[α]pyrene may be the causative agent in the formation of lung adenocarcinomas among some Taiwanese women exposed to cooking oil fumes without adequate ventilation. In this study, calf thymus DNA was modified in vitro with benzo[α]pyrene-diol epoxide (BPDE) to a level consistent with that found in biological samples. This DNA of low modification was used as an immunogen in the production of a monoclonal antibody specific for the detection of benzo[α]pyrene-DNA adducts and used in the development of a sensitive colorimetric enzyme-linked immunosorbant assay (ELISA). Following it's development, the newly developed assay will be used independently in a subsequent epidemiological study to explore the correlation between exposure to benzopyrene generated from hot cooking oils, adduct formation, and the generation of relevant carcinomas.
Study of dust-induced beam losses in the cryogenic arcs of the CERN Large Hadron Collider
Creators: name: Lechner, A.
name: Bélanger, P.
name: Efthymiopoulos, I.
name: Grob, L.
name: Lindstrom, B.
name: Schmidt, R.
name: Wollmann, D.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The interaction of dust particles with the LHC proton beams accounts for a major fraction of irregular beam loss events observed in LHC physics operation. The events cease after a few beam revolutions because of the expulsion of dust particles from the beam once they become ionized in the transverse beam tails. Despite the transient nature of these events, the resulting beam losses can trigger beam aborts or provoke quenches of superconducting magnets. In this paper, we study the characteristics of beam-dust particle interactions in the cryogenic arcs by reconstructing key observables like nuclear collision rates, loss durations and integral losses per event. The study is based on events recorded during 6.5 TeV operation with stored beam intensities of up to $\sim 3\times 10{^{14}}$ protons per beam. We show that inelastic collision rates can reach almost $10^{12}$ collisions per second, resulting in a loss of up to $\sim 1.6\times 10^{8}$ protons per event. We demonstrate that the experimental distributions and their dependence on beam parameters can be described quantitatively by a previously developed simulation model if dust particles are assumed to be attracted by the beam. The latter finding is consistent with recent time profile studies and yields further evidence that dust particles carry a negative charge when entering the beam. We also develop different hypotheses regarding the absence of higher-loss events in the measurements, although such events are theoretically not excluded by the simulation model. The results provide grounds for predicting dust-induced beam losses in presence of higher-intensity beams in future runs of the High-Luminosity LHC.
description: 19 pages, 14 figures, to be submitted to Phys. Rev. Accel. Beams
Non-Abelian Toda field theories from a 4D Chern-Simons theory
Creators: name: Fukushima, Osamu
name: Sakamoto, Jun-ichi
name: Yoshida, Kentaroh
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We derive non-abelian Toda field theories (NATFTs) from a 4d Chern-Simons (CS) theory with two order defects by employing a certain asymptotic boundary condition. The 4d CS theory is characterized by a meromorphic 1-form $ω$\,. We adopt $ω$ with two simple poles and no zeros, and each of the order defects is located at each pole. As a result, an anisotropy parameter $β^2$ can be identified with the distance between the two defects. As examples, we can derive the (complex) sine-Gordon model and the Liouville theory.
description: 23 pages
Method to Assess the Processing of Optical Information by Non-primary Riding Tasks while Riding a Motorcycle
Creators: name: S. Guth
name: M. Geiger
name: A.Parduzi
name: S. Will
name: R. Pless
name: H. Winner
Publisher: name: figshare
Year: 2016
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 91106 Special Vehicles
subject: FOS: Environmental engineering

description: A proceedings paper from BMD 2016.
Global Symmetries and Partial Confinement
Creators: name: Hanada, Masanori
name: Holden, Jack
name: Knaggs, Matthew
name: O'Bannon, Andy
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In gauge theories, spontaneous breaking of the centre symmetry provides a precise definition of deconfinement. In large-$N$ gauge theories, evidence has emerged recently that between confined and deconfined phases a partially-deconfined phase can appear, in which only a subset of colours deconfine. In the partially-deconfined phase, the centre symmetry is spontaneously broken, raising the question of whether an order parameter exists that can distinguish completely- and partially-deconfined phases. We present two examples in gauge theories of global symmetries that are spontaneously broken in the confined phase and preserved in the deconfined phase, and we show that this symmetry is spontaneously broken in the partially-deconfined phase. As a result, in these theories the transition from complete to partial deconfinement is accompanied by the spontaneous breaking of a global symmetry. The two examples are CP symmetry in $\mathcal{N}=1$ super-Yang-Mills with a massive gluino and theta-angle $θ=π$, and chiral symmetry in a strongly-coupled lattice gauge theory. For $\mathcal{N}=1$ SYM we also present numerical evidence that the same phenomenon occurs at finite $N \geq 30$. We thus conjecture that global symmetries may provide order parameters to distinguish completely and partially deconfined phases generically, including at finite $N$.
description: 42 pages + 2 appendices, 37 figure files in 18 figures
The Phonon Quasiparticle Approach for Anharmonic Properties of Solids
Creators: name: Zhang, Zhen
name: Zhang, Dong-Bo
name: Sun, Tao
name: Wentzcovitch, Renata M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Knowledge of lattice anharmonicity is essential to elucidate distinctive thermal properties in crystalline solids. Yet, accurate \textit{ab initio} investigations of lattice anharmonicity encounter difficulties owing to the cumbersome computations. Here we introduce the phonon quasiparticle approach and review its application to various materials. This method efficiently and reliably addresses lattice anharmonicity by combining \textit{ab initio} molecular dynamics and lattice dynamics calculations. Thus, in principle, it accounts for full anharmonic effects and overcomes finite-size effects typical of \textit{ab initio} molecular dynamics. The validity and effectiveness of the current approach are demonstrated in the computation of thermodynamic and heat transport properties of weakly and strongly anharmonic systems.
Using map-based dashboard to improve geo-knowledge communication: A use case on digital twins
Creators: name: Zuo, Chenyu
name: Grübel, Jascha
Publisher: name: ETH Zurich
Year: 2023
Subjects: Geovisualization
Map-based dashboard
Spatial knowledge
Digital twins

description: Abstracts of the ICA, 6
description: ISSN:2570-2106
Swift J1753.5-0127 : Understanding the accretion geometry through frequency resolved spectroscopy
Creators: name: Baby, Blessy E.
name: C, Ramadevi M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Black Hole Binary source Swift J175.5-0127 remained in outburst for $\sim$ 12 years from May 2005 to April 2017. For most part of the outburst, the source remained in the Low Hard State (LHS) displaying transitions to softer states only towards the end of the outburst for short periods of time. Quasi periodic Oscillations (QPOs) were observed in the Power Density Spectrum (PDS) only during the decay. A soft thermal component was required to model the spectrum in LHS, which does not conform to the generally accepted disc truncation theory. In this work, we attempt to obtain a clearer picture of the accretion disc geometry by studying the QPO variability using frequency resolved spectroscopy (FRS). We obtain the QPO rms spectrum of the source during the bright-hard state and model it with physical components. We find that the QPO rms spectrum can be described only by a Comptonisation component with no contribution from the thermal disc. This indicates that the variability observed in the PDS originates in the Comptonisation component and the evolution of the QPOs is likely to be a result of localization of the variabilities to different radii of the hot inner flow rather than disc truncation. The minimal variation in disc parameters also points to the existence of a stable disc throughout the outburst.
description: 9 pages; 6 figures; Accepted for publication in JoAA