title: ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÐºÐ°Ð»ÑÑÐ¸Ñ Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐºÐ°Ð½ÑÑ Ñ ÐºÑÑÑ Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¿Ð¾ÑÐµÑÐ½Ð¾Ð¹ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾ÑÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÐºÐ°Ð»ÑÑÐ¸Ñ Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐºÐ°Ð½ÑÑ ÐºÑÑÑ Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¿Ð¾ÑÐµÑÐ½Ð¾Ð¹ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾ÑÑÑÑ
Creators: name: ÐÑÐ¿ÑÐµÐµÐ²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐ¸Ð·Ð¸ÐºÐ°
Ñ ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ°Ñ Ð±Ð¾Ð»ÐµÐ·Ð½Ñ Ð¿Ð¾ÑÐµÐº
Ð½ÐµÑÑÑÐºÑÐ¾Ð¼Ð¸Ñ
Ð°ÑÑÐµÑÐ¸Ð°Ð»ÑÐ½Ð°Ñ Ð³Ð¸Ð¿ÐµÑÑÐµÐ½Ð·Ð¸Ñ
ÐºÐ°Ð»ÑÑÐ¸Ð¹
Ð¾Ð±Ð¼ÐµÐ½ ÐºÐ°Ð»ÑÑÐ¸Ñ
ÐºÐ°Ð»ÑÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð²
ÑÐµÐ¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð°
Ð³Ð¸Ð¿ÐµÑÑÑÐ¾ÑÐ¸Ñ Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¶ÐµÐ»ÑÐ´Ð¾ÑÐºÐ°
chronic kidney disease
nephrectomy
arterial hypertension
calcium
calcium exchange
calcification of organs
myocardial remodeling
left ventricular hypertrophy

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð°Â Ð¾ÑÐµÐ½ÐºÐµ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ Â¾ ÐÐ­ Ð¼Ð°ÑÑÑ Ð¿Ð¾ÑÐºÐ¸, Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ ÑÐ°Ð·Ð²Ð¸ÑÐ¸ÐµÐ¼ Ð´Ð¸ÑÑÑÐ½ÐºÑÐ¸Ð¸ Ð¿Ð¾ÑÐµÐº, Ð½Ð° Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð³Ð¾Ð¼ÐµÐ¾ÑÑÐ°Ð·Ð° ÐºÐ°Ð»ÑÑÐ¸Ñ Ñ ÐºÑÑÑ Ð»Ð¸Ð½Ð¸Ð¸ SHR Ð½Ð° ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÑÐ¾ÐºÐ°Ñ Ð½Ð°Ð±Ð»ÑÐ´ÐµÐ½Ð¸Ñ 2, 4 Ð¸ 6 Ð¼ÐµÑÑÑÐµÐ². ÐÑÐµÐ³Ð¾ n=54 Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¿ÑÐ¸Ð½Ð¸Ð¼Ð°Ð»Ð¸ ÑÑÐ°ÑÑÐ¸Ðµ Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐµ. ÐÐ½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸: ÐºÑÐµÐ°ÑÐ¸Ð½Ð¸Ð½ (sCr), Ð¼Ð¾ÑÐµÐ²Ð¸Ð½Ð° (sUr), Ð½ÐµÐ¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ¾ÑÑÐ°Ñ (sPi), ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ðµ ÐºÐ°Ð»ÑÑÐ¸Ñ (sCa) Ð² ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐµ ÐºÑÐ¾Ð²Ð¸ Ð¸ Ð°Ð½Ð°Ð»Ð¾Ð³Ð¸ÑÐ½ÑÐµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ Ð¼Ð¾ÑÐ¸: uPi, uCa, Ð´Ð¸ÑÑÐµÐ· (D). Ð¢Ð°Ðº Ð¶Ðµ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÑÐ»Ð¸ ÑÑÐ¾Ð²ÐµÐ½Ñ ÐÐ¢Ð Ð² ÑÑÐ²Ð¾ÑÐ¾ÑÐºÐµ, Â ÑÐ°ÑÑÑÐ¸ÑÑÐ²Ð°Ð»Ð¸ ÑÐºÑÐºÑÐµÑÐ¸ÑÑÐµÐ¼ÑÑ ÑÑÐ°ÐºÑÐ¸Ñ (FECa) Ð¸ Ð°Ð±ÑÐ¾Ð»ÑÑÐ½ÑÑ ÑÐºÑÐºÑÐµÑÐ¸Ñ (UCa24) Ca Ñ Ð¼Ð¾ÑÐ¾Ð¹. ÐÐµÑÐ¾Ð´Ð¾Ð¼ ÐÐÐ¡ Ð¾Ð¿ÑÐµÐ´ÐµÐ»Ð¸Ð»Ð¸ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ñ ÐºÐ°Ð»ÑÑÐ¸Ñ Ð² ÑÐºÐ°Ð½Ð¸ Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð° Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¶ÐµÐ»ÑÐ´Ð¾ÑÐºÐ° Ð¸ Ð¿Ð¾ÑÐºÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÑÑ Ð¾ ÑÐ¾Ð¼, ÑÑÐ¾ Â¾ ÐÐ­ Ð²Ð»Ð¸ÑÐµÑ Ð½Ð° ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ Ð¥ÐÐ Ñ ÐºÑÑÑ ÑÐ¶Ðµ Ð½Ð° ÑÐ°Ð½Ð½Ð¸Ñ ÑÑÐ¾ÐºÐ°Ñ Ð½Ð°Ð±Ð»ÑÐ´ÐµÐ½Ð¸Ñ, Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð½Ðµ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ñ ÐÐ, ÐÐÐ Ð¸ ÐÐÐÐÐ. Ð Ð³ÑÑÐ¿Ð¿Ðµ NE2 Ð¾ÑÐ¼ÐµÑÐ°ÐµÑÑÑ Ð·Ð½Ð°ÑÐ¸Ð¼ÑÐ¹ ÑÐ¾ÑÑ sUr, Ð¾Ð´Ð½Ð°ÐºÐ¾ ÑÑÐ¾Ð²ÐµÐ½Ñ sCr Ð±ÑÐ» Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ Ð²ÑÑÐµ Ð½Ð° Ð²ÑÐµÑ ÑÑÐ¾ÐºÐ°Ñ Ð½Ð°Ð±Ð»ÑÐ´ÐµÐ½Ð¸Ñ, ÑÐ¾ÑÑ CCr Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½Ð¾ ÑÐ½Ð¸Ð¶Ð°Ð»ÑÑ ÑÐ¾Ð»ÑÐºÐ¾ Ð½Ð° ÑÐ°Ð½Ð½ÐµÐ¼ ÑÑÐ¾ÐºÐµ Ð½Ð°Ð±Ð»ÑÐ´ÐµÐ½Ð¸Ñ. ÐÐ° Ð¿Ð¾Ð·Ð´Ð½Ð¸Ñ ÑÑÐ¾ÐºÐ°Ñ Ð¾ÑÐ¼ÐµÑÐµÐ½Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð½Ð¾Ðµ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ðµ sPi, ÑÑÐ¾ ÑÐ²Ð¸Ð´ÐµÑÐµÐ»ÑÑÑÐ²ÑÐµÑ Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð³Ð¸Ð¿ÐµÑÑÐ¾ÑÑÐ°ÑÐµÐ¼Ð¸Ð¸, ÑÑÐ¾ Ð² ÑÐ²Ð¾Ñ Ð¾ÑÐµÑÐµÐ´Ñ, ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´Ð°ÐµÑÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð³Ð¾Ð¼ÐµÐ¾ÑÑÐ°Ð·Ð° ÐºÐ°Ð»ÑÑÐ¸Ñ: ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ Ð´Ð¾Ð»Ð¸ UCa24, sCa, Ð¿Ð¾Ð²ÑÑÐµÐ½Ð½ÑÐ¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ ÐºÐ°Ð»ÑÑÐ¸Ñ Ð² ÑÐºÐ°Ð½Ð¸ Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð° Ð»ÐµÐ²Ð¾Ð³Ð¾ Ð¶ÐµÐ»ÑÐ´Ð¾ÑÐºÐ°. ÐÐ° 4 Ð¼ÐµÑÑÑ Ð¿Ð¾ÑÐ»Ðµ ÐÐ­ Ð·Ð°ÑÐ¸ÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ ÐºÐ°Ð»ÑÑÐ¸Ñ Ð² Ð¿Ð¾ÑÐµÑÐ½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¼Ð¾Ð³ÑÑ Ð¸Ð¼ÐµÑÑ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÑÑ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾ÑÑÑ Ð² ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÐºÐ¾ÑÑÐµÐºÑÐ¸Ð¸ Ð³Ð¾Ð¼ÐµÐ¾ÑÑÐ°Ð·Ð° ÐºÐ°Ð»ÑÑÐ¸Ñ Ð¿ÑÐ¸ Ð¥ÐÐ.
description: The study was devoted to the evaluation of the degree of influence of Â¾ NE of the mass kidney, followed by the development of renal dysfunction, on the changes in calcium homeostasis in SHR rats at different follow-up periods of 2, 4 and 6 months. A total of n=54 animals participated in the experiment. The following parameters were analyzed: creatinine (sCr), urea (sUr), inorganic phosphate (sPi), serum calcium content (sCa) and similar parameters of urine: uPi, uCa, diuresis (D).Also we determined serum PTH level, calculated the excreted fraction (FECa) and absolute excretion (UCa24) of Ca with urine. Calcium concentration in myocardial tissue of the left ventricle and kidney was determined by the AAS method. The results indicate that Â¾ NE affects the development of CKD in rats early in the follow-up, but does not lead to an increase in BP, MMI and MLVMI. In the NE2 group, there was a significant increase in sUr, but sCr levels were significantly higher at all follow-up periods, although CCr decreased significantly only at the early follow-up period. At late terms there was an increased content of sPi, which indicates the development of hyperphosphatemia, which, in turn, is accompanied by changes in calcium homeostasis: increase in UCa24, sCa, increased calcium content in left ventricular myocardial tissue. At the 4th month after NE a decrease in calcium concentration in the renal tissue was recorded. The experimental data obtained may be of practical significance in the development of methods of correction of calcium homeostasis in CKD.