cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Antifungal drug resistance evoked via RNAi-dependent epimutations
Creators: name: Bastidas, Robert J.
name: Nicolás, Francisco E.
name: Lee, Soo Chan
name: Heitman, Joseph
name: Calo, Silvia
name: Torres-Martínez, Santiago
name: Mieczkowski, Piotr
name: Shertz-Wall, Cecelia
name: Granek, Joshua A.
name: Cardenas, Maria E.
name: Ruiz-Vázquez, Rosa M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Microorganisms evolve via mechanisms spanning sexual/parasexual reproduction, mutators, aneuploidy, Hsp90, and even prions. Mechanisms that may seem detrimental can be repurposed to generate diversity. Here we show the human fungal pathogen Mucor circinelloides develops spontaneous resistance to the antifungal drug FK506 (tacrolimus) via two distinct mechanisms. One involves Mendelian mutations that confer stable drug resistance; the other occurs via an epigenetic RNA interference (RNAi)-mediated pathway resulting in unstable drug resistance. The peptidyl-prolyl isomerase FKBP12 interacts with FK506 forming a complex that inhibits the protein phosphatase calcineurin1. Calcineurin inhibition by FK506 blocks M. circinelloides transition to hyphae and enforces yeast growth2. Mutations in the fkbA gene encoding FKBP12 or the calcineurin cnbR or cnaA genes confer FK506 resistance (FK506R) and restore hyphal growth. In parallel, RNAi is spontaneously triggered to silence the FKBP12 fkbA gene, giving rise to drug-resistant epimutants. FK506R epimutants readily reverted to the drug-sensitive wild-type (WT) phenotype when grown without drug. The establishment of these epimutants is accompanied by generation of abundant fkbA small RNA (sRNA) and requires the RNAi pathway as well as other factors that constrain or reverse the epimutant state. Silencing involves generation of a double-stranded RNA (dsRNA) trigger intermediate from the fkbA mature mRNA to produce antisense fkbA RNA. This study uncovers a novel epigenetic RNAi-based epimutation mechanism controlling phenotypic plasticity, with possible implications for antimicrobial drug resistance and RNAi-regulatory mechanisms in fungi and other eukaryotes.
On polynomial mixing and convergence rate for stochastic difference and differential equations
Creators: name: Veretennikov, Alexander Yu.
Publisher: name: Weierstrass Institute
Year: 1998
Subjects: subject: Mixing
subject: recurrence
subject: Markov process
subject: SDE
subject: polynomial convergence
subject: 60F15
subject: 60J05
subject: 60J60

description: Polynomial bounds for β-mixing and for the rate of convergence to the invariant measure are established for discrete time Markov processes and solutions of SDEs under weak stability assumptions.
Strong and Stretchable Gels for Electroadhesion
Creators: name: Kokilepersaud, Uma Joy
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Chemical engineering
subject: FOS: Chemical engineering

description: Electroadhesion (EA) was first shown between cationic and anionic gels: when the two are contacted under an electric field (10 V DC, for ~ 20 s), they adhere strongly and remain adhered after the field is removed. Recently, our lab demonstrated that EA can also be induced between a cationic gel and animal tissues. This suggests the intriguing possibility of using EA in surgery: i.e., for gels to be electroadhered over tears in tissues. However, current gels fail to properly seal tissue-tears because either they are not strong enough (they break when stretched over the torn tissue) or do not adhere well enough to the tissue. This project aims to create a cationic gel that is strong (i.e., has high elongation-at-break ε and tensile strength TS) and exhibits strong adhesion to tissue by EA (i.e., has high pull-off strength). Our base gel, made by polymerizing an acrylamide monomer (termed ‘QDM’), is fortified by a second polymer. The optimal second polymer is shown to be gelatin, which forms physical gels upon cooling from a hot solution. QDM/gelatin gels are interpenetrating networks (IPNs) and exhibit ~ 20-30X higher ε and TS compared to QDM alone. We proceed to test if our strong gels can seal tears in chicken intestines. A tear in the tube is patched by the QDM/gelatin gel using EA, and water is then sent through the patched tube. Even for large tears (~ 3-4 mm width), the patched tube allows water to flow at a pressure exceeding 80 mm Hg (normal fluid pressure in the body). This suggests that EA could indeed be implemented in surgery using our strong QDM/gelatin gels.
Letter from the Environmental Division to the Texas Historical Commission, Fort Sam Houston, Texas
Creators: name: Walter, Chelsea
Publisher: name: Department of the Army, US Army Installation Management Command
Year: 2011
Subjects: subject: Quadrangle
valueUri: https://core.tdar.org/browse/geographic-keyword/83313/quadrangle
subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Fort Sam Houston National Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/82955/fort-sam-houston-national-historic-landmark-district
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Sally Port
valueUri: https://core.tdar.org/browse/other-keyword/158711/sally-port
subject: Quadrangle
valueUri: https://core.tdar.org/browse/other-keyword/146777/quadrangle
subject: Building 16
valueUri: https://core.tdar.org/browse/other-keyword/146154/building-16
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Joint Base San Antonio, Fort Sam Houston, is proposing an undertaking to alter the wrought iron gate and handrail that is currently installed in the sally port of the Quadrangle (building 16) at Fort Sam Houston. The Quadrangle is the oldest structure on Fort Sam Houston and is listed in the National Register of Historic Places. After careful examination of this proposal, the JB-SA Cultural Resource Staff has determined this undertaking will result in no adverse effect. This determination is based on the fact that the alterations will be to elements not part of the original structure and that are not character defining features.
Biological insights from 108 schizophrenia-associated genetic loci
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: SummarySchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here, we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain providing biological plausibility for the findings. Many findings have the potential to provide entirely novel insights into aetiology, but associations at DRD2 and multiple genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that play important roles in immunity, providing support for the hypothesized link between the immune system and schizophrenia.
On the characterization of self-regularization properties of a fully discrete projection method for Symm's integral equation
Creators: name: Pereverzev, Sergei V.
name: Prößdorf, Siegfried
Publisher: name: Weierstrass Institute
Year: 1998
Subjects: subject: Symm's integral equation
subject: ill-posed problem
subject: fully discrete projection method
subject: perturbations in the data
subject: error analysis
subject: self-regularization
subject: 65R30
subject: 65R20
subject: 45L10

description: The influence of small perturbations in the kernel and the right-hand side of Symm's boundary integral equation, considered in an ill-posed setting, is analyzed. We propose a modification of a fully discrete projection method which is more economical in the sense of complexity and allows to obtain the optimal order of accuracy in the power scale with respect to the level of the noise in the kernel or in the parametric representation of the boundary.
Catalysts from synthetic genetic polymers
Creators: name: Pinheiro, Vitor B.
name: Cozens, Christopher
name: Peak-Chew, Sew
name: Herdewijn, Piet
name: Weeks, Kevin M.
name: Smola, Matthew J.
name: Taylor, Alexander I.
name: Morgunov, Alexey S.
name: Holliger, Philipp
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The emergence of catalysis in early genetic polymers like RNA is considered a key transition in the origin of life1, predating the appearance of protein enzymes. DNA also demonstrates the capacity to fold into three-dimensional structures and form catalysts in vitro2. However, to what degree these natural biopolymers comprise functionally privileged chemical scaffolds3 for folding or the evolution of catalysis is not known. The ability of synthetic genetic polymers (XNAs) with alternative backbone chemistries not found in nature to fold into defined structures and bind ligands4 raises the possibility that these too might be capable of forming catalysts (XNAzymes). Here we report the discovery of such XNAzymes, elaborated in four different chemistries (ANA (arabino nucleic acids)5, FANA (2′-fluoroarabino nucleic acids)6, HNA (hexitol nucleic acids) and CeNA (cyclohexene nucleic acids)7 directly from random XNA oligomer pools, exhibiting in trans RNA endonuclease and ligase activities. We also describe an XNA-XNA ligase metalloenzyme in the FANA framework, establishing catalysis in an entirely synthetic system and enabling the synthesis of FANA oligomers and an active RNA endonuclease FANAzyme from its constituent parts. These results extend catalysis beyond biopolymers and establish technologies for the discovery of catalysts in a wide range of polymer scaffolds not found in nature8. Evolution of catalysis independent of any natural polymer has implications for the definition of chemical boundary conditions for the emergence of life on earth and elsewhere in the universe9.
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1994
Subjects: Community/Rural/Urban Development

description: Overview: Rural Income and Poverty Stable, Data and Reports Changing; National Economic Conditions: Growth Remains Strong in Early 1994, Fed Moves to Curb Inflation; Employment: Rural Employment Growth Stable, but Still Faster than Urban in 1993; Unemployment: Rural Unemployment Was Down in 1993, but Job Losses Remained High; Income: Rural Household Income Unchanged; Poverty: Rural Poverty Rate Remains Higher than Urban Rate; Population: Nonmetro Population Growth Widespread in Early 1990's, Countering 1980's Trend; Appendix: Data Sources and Definitions; Appendix Tables
Lorentz violation and higher-derivative gravity
Creators: name: Hernaski, C.
name: Belich, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work, we analyze a gravity model with higher derivatives including a CPT-even Lorentz-violating term. In principle, the model could be a low-energy limit of a Lorentz-invariant theory presenting the violation of Lorentz symmetry as a consequence of a spontaneous symmetry-breaking mechanism if a decoupling between the metric and the Nambu-Goldstone modes is assumed. We have set up a convenient operator basis for the expansion of wave operators for symmetric second-rank tensors in the presence of a background vector. By using this set of operators, the particle content is obtained, and its consistency, regarding the conditions for stability and unitarity, is discussed. We conclude that this extra Lorentz noninvariant contribution is unable to address the problems of stability and unitarity of higher-derivative gravity models.
description: 24 pages. Matches published version
Memorandum for Commander, Update to NAGPRA Section 6 Summary Report for Fort Sam Houston and Camp Bullis Training Site, Texas
Creators: name: Trimble, Michael K.
Publisher: name: St. Louis District, Corps of Engineers
Year: 1996
Subjects: subject: JBSA-Sam Houston
valueUri: https://core.tdar.org/browse/geographic-keyword/82532/jbsa-sam-houston
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Archaeological Overview
valueUri: https://core.tdar.org/browse/investigation-type/1/archaeological-overview
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: The U.S. Army Engineer District, St. Louis, has been designated the Corps' Mandatory Center of Expertise for the Curation and Management of Archaeological Collections. We have been tasked by the U.S. Army Environmental Center to locate and assess archaeological collections derived from Army-owned lands, to identify the federally recognized Native American tribes most likely culturally affiliated with the collections, to draft Section 6 Summary letters for each installation, and to conduct physical inventories of any collections that reportedly contain human skeletal remains or associated funerary objects to aid the Army in its effort to comply with the Native American Graves Protection and Repatriation Act (P.L. 101-601).
Noisy quantum teleportation: An experimental study on the influence of local environments
Creators: name: Knoll, Laura T.
name: Schmiegelow, Christian T.
name: Larotonda, Miguel A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report experimental results on the action of selected local environments on the fidelity of the quantum teleportation protocol, taking into account non-ideal, realistic entangled resources. Different working conditions are theoretically identified, where a noisy protocol can be made almost insensitive to further addition of noise. We put to test these conditions on a photonic implementation of the quantum teleportation algorithm, where two polarization entangled qubits act as the entangled resource and a path qubit on Alice encodes the state to be teleported. Bob's path qubit is used to implement a local environment, while the environment on Alice's qubit is simulated as a weighed average of different pure states. We obtain a good agreement with the theoretical predictions, we experimentally recreate the conditions to obtain a noise-induced enhancement of the protocol fidelity, and we identify parameter regions of increased insensibility to interactions with specific noisy environments.
description: 9 pages, 7 figures, accepted for publication in Phys. Rev. A
Letter from Richard Trevino to Mark Wolfe, Building 671 Awning, Randolph Air Force Base, Texas
Creators: name: Trevino, Richard
Publisher: name: Department of the Air Force
Year: 2011
Subjects: subject: Randolph Field Historic Landmark District
valueUri: https://core.tdar.org/browse/geographic-keyword/83364/randolph-field-historic-landmark-district
subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: NRHP
valueUri: https://core.tdar.org/browse/other-keyword/9857/nrhp
subject: Building 671
valueUri: https://core.tdar.org/browse/other-keyword/146452/building-671
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This memorandum discusses the proposed construction of an awning on the secondary elevation of building 671. It was determined that an undertaking does exist with a potential to affect historic properties, but will not alter the building's original design.
Comparative analysis of metazoan chromatin organization
Creators: name: Jung, Youngsook L.
name: Asker, Dalal
name: Alekseyenko, Artyom A.
name: Bishop, Eric
name: Chen, Ron A.-J.
name: Kundaje, Anshul
name: Riddle, Nicole C.
name: Dose, Andrea C.
name: Hu, Sheng'en Shawn
name: Minoda, Aki
name: Appert, Alex
name: Ercan, Sevinc
name: Ho, Joshua W. K.
name: Lee, Soohyun
name: Tolstorukov, Michael Y.
name: Egelhofer, Thea A.
name: Rechtsteiner, Andreas
name: Parker, Stephen C. J.
name: Ferrari, Francesco
name: Chen, Q. Brent
name: Bowman, Sarah K.
name: Liu, Tao
name: Sohn, Kyung-Ah
name: Dong, Yan
name: Day, Daniel S.
name: Feingold, Elise A.
name: Ikegami, Kohta
name: Belsky, Jason A.
name: Alver, Burak H.
name: Epstein, Charles B.
name: Duan, Xikun
name: Gu, Tingting
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosoph ...
Direct observation of the ground state of a 1/3 quantum magnetization plateau in SrMn$_3$P$_4$O$_{14}$ using neutron diffraction measurements
Creators: name: Hase, Masashi
name: Pomjakushin, Vladimir Yu.
name: Doenni, Andreas
name: Yang, Tao
name: Cong, Rihong
name: Lin, Jianhua
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We can directly investigate the ground state in magnetization-plateau fields (plateau ground state) using neutron diffraction measurements. We performed neutron diffraction measurements on the spin-5/2 trimer substance SrMn$_3$P$_4$O$_{14}$ in magnetization-plateau fields. The integrated intensities of magnetic reflections calculated using an expectation value of each spin in a plateau ground state of an isolated-trimer model agree well with those obtained experimentally in the magnetization-plateau fields. We succeeded in direct observation of a plateau ground state in SrMn$_3$P$_4$O$_{14}$.
title: “Ex-peau-sition”. Dal corpo alla dismisura dell’essere-con
Creators: name: Calabrò , Daniela
Publisher: name: Roma Tre-Press
Year: 2011

description: Il contributo prende in esame un testo di Jean-Luc Nancy dedicato a Hegel, L'inquietudine del negativo, dove il filosofo francese approfondisce la valenza speculativa e l'estensione semantica della nozione di corporeità, al fine di evidenziare l'urgenza di un pensiero del corpo nella nostra contemporaneità.

description: B@belonline vol. 10/11 Pensare con Jean-Luc Nancy
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Nel saggio l’autrice conduce un’indagine intertestuale che evidenzia i termini del “dialogo” tra antico e moderno in cui la Commedia dantesca torna prepotentemente a costituire la fonte, sempre viva e attuale, a cui Sergio Conca Bonizzoni, attinge copiosamente per la stesura del romanzo I delitti di Dante.
DEVELOPING A PERRENIAL LIVING MULCH SYSTEM FOR MANAGING PESTS AND AUGMENTING NATURAL BIOCONTROL IN MARYLAND CANTALOUPE SYSTEMS
Creators: name: Nunez, Demian Antonio
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Entomology
subject: Agriculture
subject: Ecology
subject: FOS: Biological sciences
subject: Biocontrol
subject: Cantaloupe
subject: Cucumber beetle
subject: IPM
subject: Living mulch
subject: Pest control

description: This study investigated how alsike clover (Trifolium hybridum) and Virginia wildrye (Elymus virginicus), when interplanted as a living mulch with cantaloupe, (Cucumis melo var. cantalupensis) would impact herbivorous and beneficial arthropod numbers. An additional objective was to determine how these living mulches would impact fruit yield and quality. It was hypothesized that there would be a reduction of cantaloupe pest herbivores and increase in natural enemy abundances in the interplanting compared to monoculture cantaloupe system. Some arthropods conformed to these expectations. However, most had a neutral or inconsistent response to the living mulches. Striped cucumber beetles (Acalymma vitattum), a major pest, were unaffected by the living mulches on most sampling dates. During several periods in both study years, leaf piercing herbivores including aphids were found in greater numbers on cantaloupe interplanted with clover than wildrye and/or monoculture. Spiders were found in greater abundance in cantaloupe interplanted with clover than wildrye or monoculture plantings during several sampling periods. Other natural enemy guilds such as parasitic wasps and piercing predators were inconsistently influenced by living mulch types. Yield was highest in the monoculture plots and living mulch was correlated with changes in fruit texture and color.
Physical Fitness Development through Blended Training of 3-year Students from the Faculty of Sports Science and Technology of Bangkok Thonburi University
Creators: name: Thawatchai Kaithongsuk
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Cross Training
Plyometric Training
Physical Fitness

description: Interdisciplinary Academic and Research Journal, 3, 3, 739-752
Comprehensive molecular characterization of gastric adenocarcinoma
Creators: name: Bowlby, Reanne
name: Taylor-Weiner, Amaro
name: Chu, Andy
name: Sougnez, Carrie
name: Weinhold, Nils
name: Reynolds, Sheila M.
name: Mills, Gordon B.
name: Bernard, Brady
name: Liu, Wenbin
name: Shmulevich, Ilya
name: Curtis, Christina
name: Mungall, Andrew J.
name: Noble, Michael S.
name: Gordon Robertson, A.
name: Kelsen, David P.
name: Bass, Adam J.
name: Sipahimalani, Payal
name: Cherniack, Andrew
name: Shen, Hui
name: Hinoue, Toshinori
name: Akbani, Rehan
name: Weisenberger, Daniel J.
name: Thorsson, Vesteinn
name: Liu, Yingchun
name: Lee, Ju-Seog
name: Schultz, Nikolaus
name: Kasaian, Katayoon
name: Getz, Gad
name: Pedamallu, Chandra
name: Shen, Ronglai
name: Laird, Peter W.
name: Miller, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.
Deciphering Core Records of Carbon and Nitrogen in Typha-Dominated Freshwater Wetlands
Creators: name: Ravi, Rumya
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Hydrologic sciences
subject: Geochemistry

description: I conducted decomposition experiments and examined soil characteristics in restored and natural freshwater marsh platform sites to decipher core records of soil C and N. Carbon loss rates and changes in ẟ13C and ẟ15N were obtained from decomposition experiments. Core samples at each site were analyzed for bulk density, weight %C, %N, ẟ13C, and ẟ15N. Typha C loss rates were similar among sites, and there was little change in ẟ13C composition, suggesting that DOC leaching is significant. Core carbon storage is higher in natural wetland sites. Initial Typha %N and ẟ15N reflect local N concentrations and sources to each wetland. ẟ15N increases between decomposed vegetation and upper cores in the tidal wetlands, possibly indicating denitrification. In N-rich wetlands, core %N and ẟ15N reflect differences in N sources and changes in N sources over time. In a wetland limited by N transport, core %N and ẟ15N may reflect vegetation N uptake.
Comprehensive molecular characterization of urothelial bladder carcinoma
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. To date, no molecularly targeted agents have been approved for the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomas to provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell cycle regulation, chromatin regulation, and kinase signaling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which (papillary-like and basal/squamous-like) were also evident in miRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours, including 42% with targets in the PI3K/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any common cancer studied to date, suggesting the future possibility of targeted therapy for chromatin abnormalities.
Investigation of transient surface electric field induced by femtosecond laser irradiation of aluminum
Creators: name: Li, Run-Ze
name: Zhu, Pengfei
name: Chen, Long
name: Xu, Tong
name: Chen, Jie
name: Cao, Jianming
name: Sheng, Zheng-Ming
name: Zhang, Jie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Transient surface electric fields induced by femtosecond laser irradiation of an aluminum film were investigated directly by ultrashort electron pulses. At pump intensities of 2.9~7.1 * 10^10 W/cm2, the transient electric fields last at least one nanosecond with a maximum field strength of 3.2~5.3 * 10^4 V/m at 120 micro m above the aluminum surface. The transient electric fields and the associated evolution of photoelectrons were explained by a "three-layer" model. The potential influence of such fields on reflection ultrafast electron diffraction and time-resolved angle-resolved photoemission spectroscopy were evaluated.
description: 24 pages, 6 figures, 3 tables
Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network
Creators: name: Travis, William D.
name: Ladanyi, Marc
name: Lee, William
name: Beer, David G.
name: Hernandez, Bryan
name: Kwiatkowski, David
name: Tsao, Ming-Sound
name: Campbell, Joshua D.
name: Jurisica, Igor
name: Chu, Andy
name: Berger, Alice H.
name: Hammerman, Peter S.
name: Robertson, Gordon
name: Kucherlapati, Raju
name: Collisson, Eric A.
name: Schultz, Nikolaus
name: Danilova, Ludmila
name: Sougnez, Carrie
name: Getz, Gad
name: Shen, Ronglai
name: Creighton, Chad J.
name: Weinstein, John N.
name: Heymach, John V.
name: Cope, Leslie
name: Wigle, Dennis A.
name: Wilkerson, Matthew D.
name: Brooks, Angela N.
name: Neil Hayes, D.
name: Ding, Li
name: Sinha, Rileen
name: Chmielecki, Juliann
name: Herman, James G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis.
Basket Asian Relative Performance Option Valuation
Creators: name: Lee, David
Publisher: name: Zenodo
Year: 2023
Subjects: Basket Asian Relative Performance Option Valuation

description: A pricing model for basket Asian relative performance options (RPO) is proposed by using Monte Carlo simulation. In a basket Asian RPO, payoff is determined by the difference between the performance of a reference stock and that of a basket of stocks, where performance is defined as the ratio of (weighted) average of two sets of averaging dates.
description: https://ia904708.us.archive.org/21/items/fxOptionBGM/fxOptionBGM.pdf
Fermi-Level Pinning, Charge Transfer, and Relaxation of Spin-Momentum Locking at Metal Contacts to Topological Insulators
Creators: name: Spataru, Catalin D.
name: Leonard, Francois
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Topological insulators are of interest for many applications in electronics and optoelectronics, but harnessing their unique properties requires detailed understanding and control of charge injection at electrical contacts. Here we present large-scale ab initio calculations of the electronic properties of Au, Ni, Pt, Pd, and graphene contacts to Bi2Se3. We show that regardless of the metal, the Fermi level is located in the conduction band, leading to n-type Ohmic contact to the first quintuplet. Furthermore, we find strong charge transfer and band-bending in the first few quintuplets, with no Schottky barrier for charge injection even when the topoplogical insulator is undoped. Our calculations indicate that Au and graphene leave the spin-momentum locking mostly unaltered, but on the other hand, Ni, Pd, and Pt strongly hybridize with Bi2Se3 and relax spin-momentum locking. Our results indicate that judicious choice of the contact metal is essential to reveal the unique surface features of topological insulators.
description: Manuscript + Supplemental Material
Letter from Joseph Logan to Claudia Nissley, Rehabilitation of Hangar 13, Randolph Air Force Base, Texas
Creators: name: Logan, Joseph M.
Publisher: name: Department of the Air Force, Randolph Air Force Base
Year: 1992
Subjects: subject: San Antonio
valueUri: https://core.tdar.org/browse/geographic-keyword/4149/san-antonio
subject: Bexar (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4150/bexar-county
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Randolph Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/78971/randolph-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/318/governmental-structure
subject: Historic Governmental Structure
valueUri: https://core.tdar.org/browse/site-type/320/historic-governmental-structure
subject: Hangar 13
valueUri: https://core.tdar.org/browse/other-keyword/158749/hangar-13
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: Summary documentation on a proposed undertaking that may effect Hangar 13 at Randolph Air Force Base, Texas. Randolph Air Force Base has determined the project will have No Adverse Effect on the historic property. This letter is part of correspondence and summary documentation on a proposed rehabilitation of Hangar 13, Randolph Air Force Base, Texas. The project includes the renovation of the interior, replace original exterior metal doors, and construct a new building entrance addition.
DESIGN OF A LOW-COST PORTABLE HANDHELD SPECTROMETER FOR AEROSOL OPTICAL DEPTH MEASUREMENTS
Creators: name: LaRosa, Anthony
Publisher: name: Digital Repository at the University of Maryland
Year: 2022
Subjects: subject: Engineering
subject: Electrical engineering
subject: Optics
subject: aerosol
subject: CMOS
subject: sensor
subject: spectrometer

description: The impact aerosols have on human health and the climate continues to be a central topic in scientific research. The quantification of aerosol abundance in the atmosphere is a key factor in understanding the climate, Earth’s radiative budget, and their impacts to human health. This research focuses on the development and comprehensive assessment of a handheld field instrument that measures aerosol optical thickness. The challenges associated with designing a low-cost, durable handheld system with highly sensitive electronics, which is capable of direct-sun measurements, are investigated. The thesis work can be summarized as follows. First, the electrical, mechanical, and optical integration needed for the instrument development is discussed and presented. Second, the sensitivities of a compact micro spectrometer are analyzed in both the laboratory and field deployment studies. The spectrometer and the fully integrated instrument are characterized in terms of its spectral resolution, sensitivity, thermal characteristics, and stability. Finally, after successful performance characterization, the capabilities of the instrument for field measurements are explored by taking direct sun measurements. The results demonstrate that the instrument has great potential to be used as a rigorous scientific device or a citizen science, educational instrument for aerosol optical depth measurements.
Remnants of Black Rings from Gravity's Rainbow
Creators: name: Ali, Ahmed Farag
name: Faizal, Mir
name: Khalil, Mohammed M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we investigate a spinning black ring and a charged black ring in the context of gravity's rainbow. By incorporating rainbow functions proposed by Amelino-Camelia, et al. in [arXiv:hep-th/9605211, arXiv:0806.0339v2] in the metric of the black rings, a considerable modification happens to their thermodynamical properties. We calculate corrections to the temperature, entropy and heat capacity of the black rings. These calculations demonstrate that the behavior of Hawking radiation changes considerably near the Planck scale in gravity's rainbow, where it is shown that black rings do not evaporate completely and a remnant is left as the black rings evaporate down to Planck scale.
description: 14 pages, 6 figures
Warehouse 1 Building 80, Blueprint, Camp Bullis, Texas
Creators: name: Brin, Adam
Year: 1930
Subjects: subject: Camp Bullis
valueUri: https://core.tdar.org/browse/geographic-keyword/82533/camp-bullis
subject: Texas
valueUri: https://core.tdar.org/browse/geographic-keyword/6923/texas
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Heritage Management
valueUri: https://core.tdar.org/browse/investigation-type/24/heritage-management

description: This is a blueprint of Warehouse 1, building 80, at Camp Bullis, Texas. The drawing accompanies form 117 detailing building 80.
Copper is required for oncogenic BRAF signalling and tumorigenesis
Creators: name: Knapp, Stefan
name: Yao, Xiaojie
name: Counter, Christopher M.
name: Campbell, Sharon L.
name: Hobbs, G. Aaron
name: Thiele, Dennis J.
name: Crowe, Matthew S.
name: Brady, Donita C.
name: Xiao, Kunhong
name: Turski, Michelle L.
name: Chaikuad, Apirat
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The BRAF kinase is mutated, typically V600E, to induce an active oncogenic state in a large fraction of melanoma, thyroid, hairy cell leukemia, and to a lesser extent, a wide spectrum of other cancers1,2. BRAFV600E phosphorylates and activates the kinases MEK1 and MEK2, which in turn phosphorylate and activate the kinases ERK1 and ERK2, stimulating the MAPK pathway to promote cancer3. Targeting MEK1/2 is proving to be an important therapeutic strategy, as a MEK1/2 inhibitor provides a survival advantage in metastatic melanoma4, which is increased when co-administered with a BRAFV600E inhibitor5. In this regard, we previously found that copper (Cu) influx enhances MEK1 phosphorylation of ERK1/2 through a Cu-MEK1 interaction6. We now show that genetic loss of the high affinity Cu transporter Ctr1 or mutations in MEK1 that disrupt Cu binding reduced BRAFV600E-driven signaling and tumorigenesis. Conversely, a MEK1-MEK5 chimera that phosphorylates ERK1/2 independent of Cu or an active ERK2 restored tumor growth to cells lacking Ctr1. Importantly, Cu chelators used in the treatment of Wilson disease7 reduced tumor growth of both BRAFV600E-transformed cells and cells resistant to BRAF inhibition. Taken together, these results suggest that Cu-chelation therapy could be repurposed to treat BRAFV600E mutation-positive cancers.
Mesenchymal–endothelial transition contributes to cardiac neovascularization
Creators: name: Lu, Yan
name: Ubil, Eric
name: Vondriska, Thomas M.
name: Stefani, Enrico
name: Wu, Yong
name: Rosa-Garrido, Manuel
name: Deb, Arjun
name: Rojas, Mauricio
name: Bargiacchi, Francesca
name: Stanbouly, Seta
name: Pillai, Indulekha C. L.
name: Duan, Jinzhu
name: Huang, Jie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal-transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and directly contribute to neovascularization after cardiac injury is not known. Here, using genetic fate map techniques, we demonstrate that cardiac fibroblasts rapidly adopt an endothelial cell like phenotype after acute ischemic cardiac injury. Fibroblast derived endothelial cells exhibit anatomical and functional characteristics of native endothelial cells. We show that the transcription factor p53 regulates such a switch in cardiac fibroblast fate. Loss of p53 in cardiac fibroblasts severely decreases the formation of fibroblast derived endothelial cells, reduces post infarct vascular density and worsens cardiac function. Conversely, stimulation of the p53 pathway in cardiac fibroblasts augments mesenchymal to endothelial transition, enhances vascularity and improves cardiac function. These observations demonstrate that mesenchymal-to-endothelial-transition contributes to neovascularization of the injured heart and represents a potential therapeutic target for enhancing cardiac repair.
Molecular control of δ-opioid receptor signalling
Creators: name: Giguere, Patrick M.
name: Katritch, Vsevolod
name: Roth, Bryan L.
name: Fenalti, Gustavo
name: Huang, Xi-Ping
name: Stevens, Raymond C.
name: Cherezov, Vadim
name: Thompson, Aaron A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Opioids represent widely prescribed and abused medications, although their signal transduction mechanisms are not well understood. Here we present the 1.8Å high-resolution crystal structure of the human δ-opioid receptor (δ-OR), revealing the presence and fundamental role of a sodium ion mediating allosteric control of receptor functional selectivity and constitutive activity. The distinctive δ-OR sodium ion site architecture is centrally located in a polar interaction network in the 7-transmembrane bundle core, with the sodium ion stabilizing a reduced agonist affinity state, and thereby modulating signal transduction. Site-directed mutagenesis and functional studies reveal that changing the allosteric sodium site residue Asn131 to alanine or valine augments constitutive arrestin-ergic signaling. Asp95Ala, Asn310Ala, and Asn314Ala mutations transform classical δ-opioid antagonists like naltrindole into potent β-arrestin-biased agonists. The data establish the molecular basis for allosteric sodium ion control in opioid signaling, revealing that sodium-coordinating residues act as “efficacy-switches” at a prototypic G protein-coupled receptor.
Testing bi-orderability of knot groups
Creators: name: Clay, Adam
name: Desmarais, Colin
name: Naylor, Patrick
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Topology (math.AT)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25, 57M27, 06F15

description: We investigate the bi-orderability of two-bridge knot groups and the groups of knots with 12 or fewer crossings by applying recent theorems of Chiswell, Glass and Wilson. Amongst all knots with 12 or fewer crossings (of which there are 2977), previous theorems were only able to determine bi-orderability of 599 of the corresponding knot groups. With our methods we are able to deal with 191 more.
description: 10 pages, 1 figure
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Creators: name: Tšernikova, Natalia
name: Stolk, Lisette
name: Ganna, Andrea
name: McMahon, George
name: Esko, Tõnu
name: Amin, Najaf
name: Perry, John R. B.
name: Corre, Tanguy
name: Johnson, Andrew D.
name: Porcu, Eleonora
name: Wagner, Erin K.
name: Day, Felix
name: Thorleifsson, Gudmar
name: Thompson, Deborah J.
name: Elks, Cathy E.
name: Tikkanen, Emmi
name: Feenstra, Bjarke
name: Franceschini, Nora
name: Ferreira, Teresa
name: Sulem, Patrick
name: Nolte, Ilja M.
name: Smith, Albert V.
name: Albrecht, Eva
name: Ulivi, Sheila
name: Lunetta, Kathryn L.
name: Chasman, Daniel I.
name: Paternoster, Lavinia
name: Kjellqvist, Sanela
name: Cousminer, Diana L.
name: Ang, Wei Q.
name: He, Chunyan
name: Teumer, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality1. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation2,3, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P<5×10−8) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1/WDR25, MKRN3/MAGEL2 and KCNK9) demonstrating parent-of-origin specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and gamma-aminobutyric acid-B2 receptor signaling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.
Kartierung und Beschreibung der Open-Access-Dienste in Deutschland
Creators: name: Stalla, Maria
name: Biela, Jan
name: Hohmann, Lukas
name: Witteler, Sebastian
name: Holzer, Angela
name: Hillenkötter, Kristine
name: Schäffler, Hildegard
name: Ferguson, Lea Maria
name: Siegert, Olaf
name: Tullney, Marco
Publisher: name: Zenodo
Year: 2023
Subjects: Open Access
Infrastructures
OA-System
Mapping
scholar-led

description: Die Allianz der Wissenschaftsorganisationen treibt seit 2008 im Rahmen der Schwerpunktinitiative „Digitale Information“ die Modernisierung der wissenschaftlichen Informationsversorgung voran. Die Arbeitsgruppe „Wissenschaftliches Publikationssystem“ befasst sich dabei mit der Ausschöpfung des Potentials digitalen Publizierens, vor allem durch die Unterstützung der Transformation des wissenschaftlichen Publikationswesens in Richtung Open Access und die Stärkung einer nachhaltigen und wissenschaftsfreundlichen Organisation des Publikationswesens. In diesem Rahmen hat die Deutsche Forschungsgemeinschaft (DFG) die Technopolis Deutschland GmbH mit der Durchführung einer Studie zur Kartierung und Beschreibung von Open-Access-Diensten und -Infrastrukturen beauftragt. Die Ergebnisse bieten einen Überblick über den Status Quo der für OA-Publikationen unerlässlichen Infrastrukturen und erlauben es, Handlungsoptionen für die Ausräumung von strukturellen Hindernissen der Transformation des Publikationssystems abzuleiten und diese perspektivisch zu formulieren. Die Studie umfasste im ersten Schritt die Identifikation verschiedener Dienste und Infrastrukturen. Im zweiten Schritt folgte die Erhebung von Detailinformationen wie Reichweite, Nachfrage, Finanzierung und Nachhaltigkeit sowie Forschenden- und Expert*innen-Perspektiven auf das öffentliche OA-System.