cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Amphicnaeia interrupta Galileo & Martins 2003
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Amphicnaeia
Amphicnaeia interrupta

description: Amphicnaeia interrupta Galileo & Martins, 2003
Galileo & Martins, 2003c:168, fig. 1.
Paratype ♀, COLOMBIA, Cauca: Isla Gorgona (Parque Nacional Natural, Mancora, 2°58’N, 78°11’W), 24.IV.2000, H. Torres col. (MCNZ 233.945).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Amphicnaeia nigra Galileo & Martins 2001
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Amphicnaeia
Amphicnaeia nigra

description: Amphicnaeia nigra Galileo & Martins, 2001
Galileo & Martins, 2001a:39, fig. 1.
Holotype ♀, BRAZIL, Rio Grande do Sul: São Francisco de Paula (Fazenda Três Cachoeiras), 03.II.1999, L. Moura col. (MCNZ 233.944).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Additional file 1: Table S1. of Sequence-based prediction of permissive stretches for internal protein tagging and knockdown
Creators: name: Oesterle, Sabine
name: Roberts, Tania
name: Widmer, Lukas
name: Mustafa, Harun
name: Panke, Sven
name: Billerbeck, Sonja
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Mapping of known permissive sites within TpiA and Bla. A known permissive site (first column, given as residue number) within TpiA and Bla [32] was assigned to a predicted stretch (PS) if it mapped directly within a PS (see Additional file 3: Figure S1 for illustration) or if it was shifted by few residues but at least mapped to the same secondary structural element (“scattered” permissive sites). The number of residues by which a given “scattered” site is shifted is given in column 5. Note that, due to the experimental approach, which selected for only functional protein variants, there are no known non-permissive sites for TpiA. (DOCX 90 kb)
Youth Vaping in Los Angeles: Youths’ Perceptions, Behaviors, and Outlet Density
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: East (ELA) and South (SLA) Los Angeles are icons for the plight and struggle for inner-city health. Together, these neighborhoods lay at the epicenter for the State's worsening ethnic/racial tobacco and marijuana-health disparities (TMHD), neighborhood violence, and lower health status among residents, especially among adolescents. Early adolescent use of tobacco and marijuana confers a heightened risk for addiction, psychiatric and medical disorders, poor psychosocial functioning, and death.The popularity and normalization of new tobacco products among adolescents, in particular, vaping, has exacerbated this public health epidemic in L.A. It has also far outpaced research on the role of tobacco marketing on behaviors revealing a tremendous gap in public health regarding the potential health effects and long-term consequences on health behaviors. Despite the proliferation of adolescent vaping and evidence of associations of vaping with marijuana initiation, research on adolescent access patterns and the synergistic geographic marketing strategies of new tobacco products and marijuana vaping are scant. Having a better understanding of the commercial and social factors that guide adolescents’ decisions to use vaping and marijuana products can be critical in informing regulatory policies on new tobacco and marijuana products. In order to address the intricacies from social, economic, geographical, and historical forces surrounding tobacco outlets, tobacco products, adolescent use and TMHD, this proposal integrates quantitative spatial data and qualitative interviews from adolescents in order to understand the experiences of adolescents with tobacco outlets and social sources (suppliers). This study will explore the commercial and social factors that guide adolescents’ decisions to use vaping and marijuana products; once observed, these findings can be critical in informing efforts to effectively regulate new tobacco and marijuana products for youth and help increase our understanding of TMHD.
Understanding the effects of e-cigarettes on airway epithelial repair and homeostasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cells of the lung that are in direct contact with the environment, the proximal airway epithelial cells, play a vital role in host defense. Combustible tobacco smoke injures these cells, preventing their healthy maintenance (homeostasis) and their repair. However, the effects of e-cigarette components on airway epithelial repair and homeostasis have not been studied. There is a great need to understand the effects of these new tobacco products on the airway epithelium and in particular on the airway basal stem cells (ABSCs) as these are the cells that are needed for normal airway epithelial repair after injury. We will study ABSCs, both as cells growing in culture dishes (in vitro model) and in animals (in vivo model), to assess specific effects of the components of e-cigarette aerosols on airway repair. We hypothesize that these new tobacco products will cause airway injury and aberrant airway repair. Aim 1a will test e-cigarette aerosol components in the in vitro air-liquid interface model that we have adapted for moderate throughput screening, by performing a pilot screen of available e-cigarette mango brands and assessing the airway epithelium. We will also develop our e-cigarette aerosolization platform into a high throughput system. Aim 1b will use an in vivo tracheal injury-repair model that we have extensively characterized to further examine the effects of these mango flavored e-cigarette brands. Aim 2 follows from preliminary data showing that mango flavored Juul aerosols induce production of potentially damaging molecules, called reactive oxygen species (ROS), in the ABSCs. This aim addresses the mechanisms of ROS-induced injury in the airway. Completion of these aims will provide a global assessment of the effects of e-cigarette components on the airway and ultimately the goal is to provide data that can inform FDA regulation of e-cigarettes.
Raman spectroscopy to investigate early biochemical alterations in human tears caused by contact lenses
Creators: name: Rolandi, Riccardo
name: Duse, Alessandro
name: Tavazzi, Silvia
name: Grandori, Rita
name: Pezzoli, Fabio
name: Ponzini, Erika
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The interaction between contact lenses and tear film plays a critical role in lens biocompatibility and can influence discomfort during wear. Early detection of biochemical changes is important for improving ocular surface health, preventing complications, and developing advanced lens materials to enhance long-term comfort. The pursuit of biocompatible lens materials requires a thorough understanding of their interaction with tear environment. The aim of this study is to evaluate different approaches to investigate early alterations in tear biomolecular profiles induced by lens wear. Two participants wore different CLs and underwent ocular analysis before CL insertion (T0), after 2-hour wear (T2), and two hours after removing the CL (T4), evaluating non-invasive tear break-up time (NIBUT), tear meniscus height (TMH), and osmolarity. Forty CLs were used. At the same time points, tears were collected and analysed by Raman spectroscopy. Tear film stability, as measured by NIBUT, decreased post-lens wear (T0 vs T2, p = 0.034 and 0.025 for S1 and S2, respectively) but showed recovery within 2 hours (T0 vs T4, p > 0.05 for both S1 and S2), while TMH and osmolarity remained unchanged (T0 vs T2 vs T4, p > 0.05 for both S1 and S2). Raman spectroscopy highlighted notable changes in the biomolecular profile of tears after lens wear, particularly in the 2700–3200 cm−1 spectral window related to C-H stretching, which is sensitive to CH, CH2 and CH3 groups, their functional chemistry group, and the surrounding microenvironment. Contact lens wear induces subtle biochemical, subclinical alterations in tears that can be detected early by Raman spectroscopy. The method is promising for analysing the subject-specific responses to lenses, also with possible individual variability in the timing of these changes. In addition, this approach can provide insights for designing biocompatible materials and for the early detection of subclinical biomarkers.
Extra sensory perception
Creators: name: Schenck, Elizabeth S.
Publisher: name: No Publisher Supplied
Year: 1979

description: A short history of the study of ESP (or paranormal happenings or parapsychology). Defines clairvoyance, telepathy and precognition. Well known figures in the field are discussed: mediums Eusapia Palladino of Italy, Mrs. Leonora Piper, and Dr. Joseph Banks Rhine then on the faculty of Duke University.
Bebelis compta Galileo & Martins 2006
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Bebelis
Bebelis compta

description: Bebelis compta Galileo & Martins, 2006
Galileo & Martins, 2006b:17, fig. 6.
Holotype ♂, BRAZIL, Rio Grande do Sul: Triunfo (Parque Copesul) 24.VIII.2004, R. Moraes col. (MCNZ 234.430). Paratypes 3♂, ♀ BRAZIL, Rio Grande do Sul: Triunfo (Parque Copesul), 08.XI.1988, M. H. Galileo col, 21.X.2003, A. Barcellos col., 24.VIII.2004, R. Ott col., 29.VII. 2003, R. Ott & A. Barcellos col. (MCNZ 150.290, 223.172, 234.431, 222.594).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Folsomia manolachei Bagnall 1939
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia manolachei

description: Folsomia manolachei Bagnall, 1939
– Folsomia manolachei Bagnall, 1939 a: 58.
KS: Arbea & Kahrarian 2015b; GO: Yoosefi Lafooraki et al. 2020b; MAZ: Bakhshi et al. 2022; Vahedi Moghadam et al. 2022; KU: Ahmadi et al. 2023.
Ecology and habitat in Iran: soil.
General distribution: Palaearctic and Western Nearctic (?) (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 43, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Psychological warfare
Creators: name: Dey, Mary Gray
Publisher: name: No Publisher Supplied
Year: 1980

description: Provides 20th century definitions and examples of psychological warfare including the practice of brainwashing, with detail about John D. Hayes as recorded by Edward Hunter in his book "Brainwashing in Red China, the Calculated Destruction of Men's Minds." Propaganda as a tool in brainwashing is defined. Lastly, terrorism is presented as a form of psychological warfare, used as a tool for an armed Marxist revolution.  Bibliography on last page.
Additional file 7: Table S3. of Sequence-based prediction of permissive stretches for internal protein tagging and knockdown
Creators: name: Oesterle, Sabine
name: Roberts, Tania
name: Widmer, Lukas
name: Mustafa, Harun
name: Panke, Sven
name: Billerbeck, Sonja
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Strains used in this study. (DOCX 20 kb)
Women in the field of medicine
Creators: name: Wilmot, Anita
Publisher: name: No Publisher Supplied
Year: 1985

description: Synopsis of various women in medicine: Edith Blackwell (first woman graduate of US medical school), Clarissa Barton (founder of American Red Cross), Anna Fisher (physician and woman astronaut), Susan La Flesche Picotte (Native American physician), Barbara Lynn Ivey Yarn (African American physician), Grace Arabell Goldsmith (leading researcher on nutritional deficiency diseases), Nancy Wexler (physician and president of Hereditary Disease Foundation). Traits common among these women are reviewed.
Sound of music
Creators: name: Joyce, Ann
Publisher: name: No Publisher Supplied
Year: 1981

description: The history of music beginning with what scholars believe the to be the earliest music in the time of the caveman, centered on the bone as an instrument. The development of instruments and musical styles follows through the ages up to rock music. The importance of the ear and the replication of sounds in nature are described. The possibility is posed that chanting existed long before singing,  based on the development of man's mouth and tongue.
Folsomia penicula Bagnall 1939
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia penicula

description: Folsomia penicula Bagnall, 1939
– Folsomia penicula Bagnall, 1939 a: 57.
CE, EA: Cox 1982; LO: Moradi et al. 2019; GO: Falahati et al. 2011; Falahati 2012; Falahati et al. 2013b; Yoosefi Lafooraki et al. 2020b; GI: Daghighi 2012; Daghighi et al. 2013a, b; Yoosefi Lafooraki et al. 2020b; TE: Qazi & Shayanmehr 2014; Yahyapour et al. 2019; MAZ: Yoosefi Lafooraki 2014; Yoosefi Lafooraki & Shayanmehr 2014a, b; Mehrafrooz Mayvan et al. 2015a; Ghasemi Cherati 2017; Yoosefi Lafooraki et al. 2020b; Bakhshi et al. 2022; NK: Mehrafrooz Mayvan et al. 2022a; KS: Arbea & Kahrarian 2015b; Kahrarian 2015; KU: Ahmadi et al. 2023.
Ecology and habitat in Iran: soil under oak trees.
Remarks: Cox 1982, Daghighi et al. 2013 a and Falahati et al. 2013a mentioned this species as Folsomia multiseta Stach, 1947 that is considered as junior synonym of F. penicula.
General distribution: Western Palaearcic and Western Nearctic (Babenko et al. 2019) and Iran.
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 43, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Does California beef have growth promotant residues and do they pose a breast cancer risk?
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Slow-release hormonal growth promotants (HGP) are used widely in beef production to increase the rate of muscle deposition and are proposed to be safe based on the premise they only transfer minimal amounts of hormone to end consumers. Cells within the normal breast and some breast cancers are acutely sensitive to steroid hormones and chemicals that mimic their activity, including a woman’s own hormones. Any HGP residues in beef could therefore potentially increase a woman’s risk for developing breast cancer. Currently there is insufficient publicly-available information to define the levels of HGP in beef consumed by Californians.

 Our objective is to sample conventional, organic and “no added hormone” ground beef and steak at eight different retail outlets in Northern, Southern and central/rural California, to measure their HGP levels, and to determine the underlying sex of the animal(s) for each sample to control for naturally-occurring hormones. We will then use these data to determine the potential intake of HGP by girls and women in different regions who might consume beef products, and to predict the potential impact on their risks for developing breast cancer.

 This will be the first large scale pilot study measuring different HGP levels that may exist in beef sold to consumers in California, including ‘no added hormone’ produced beef and organic beef. The outcomes from this project will be disseminated through different stakeholders including those from the beef production and marketing sectors as well as the cancer research community. Finally, the findings will be broadly shared with our community advocates who will ensure we consider directions that are meaningful to breast cancer patients and survivors.
Megatrends in our climate
Creators: name: Joyce, Ann
Publisher: name: No Publisher Supplied
Year: 1984

description: Brief historic trends of climate change from the Mesozoic era through the 1980s. Covers scientific research and the effects of fossil fuels, greenhouse gases, sunspots, glaciers and El Nino. Refers to U.S. legislation and regulation as well as pros and cons of various sources of energy. Attention to fusion as the writer's husband was the chief engineer on the fusion project at Princeton University.
Bebelis concisa Galileo & Martins 2006
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Bebelis
Bebelis concisa

description: Bebelis concisa Galileo & Martins, 2006
Galileo & Martins, 2006b:17, fig. 7.
Holotype ♂, BRAZIL, Rio Grande do Sul: Triunfo (Parque Copesul) 24.XI.1999, M. H. Galileo col. (MCNZ 215.583). Paratypes ♂, ♀, BRAZIL, Rio Grande do Sul: Triunfo (Parque Copesul), 11.IX.1992, 12.IX.1992, L. Moura col. (MCNZ 215.577, 215.578).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 448, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Preclinical development of a first-in-class PCNA inhibitor for treating small cell lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: There currently are no highly effective target-based therapies to treat small cell lung cancer (SCLC). While inhibitors of specific growth factor receptors provide short-term effective treatment for certain forms of SCLC, this approach ultimately fails, and patients ultimately succumb to the disease. Studies have disproportionately linked individuals from lower socioeconomic strata to development of SCLC. This is in part due to their disproportionate use of tobacco products, (including smoking tobacco), elevated exposure to second hand smoke, and to a variety of occupational risk factors, that lead to elevated rates of SCLC development, (relative to individuals from middle and upper socioeconomic strata). Taken together, these factors underscore a pressing social and unmet medical need, for developing novel highly effective target-based therapy capable of improving the clinical outcome for SCLC patients. To this end, we have developed a unique inhibitor of a cancer associated isoform of the PCNA protein, (i.e., Proliferating Cell Nuclear Antigen (caPCNA)). caPCNA is an attractive molecular target for developing selective inhibitors because blocking caPCNA function selectively leads to the specific killing of SCLC cells; while sparing healthy cells. The caPCNA selective inhibitor (AOH1996) selectively kills SCLC cells, but has no discernible toxicity to non-cancer cells in both cell culture and initial animal model studies. Studies described in this proposal are aimed at: 1) optimizing formulation composition for AOH1996 oral administration in animal models requested by the FDA; 2) providing preliminary data for an application for FDA Investigation New Drug (IND); and 3) evaluating 8 identified potential cellular response biomarkers for their ability to stratify patients according to their sensitivity to treatment with AOH1996. Following discussion with the FDA, we have been assured that the anticipated data from our proposed studies will complete the pre-clinical studies required to move AOH1996 into clinical testing. Additionally, data derived from this proposal will inform design of clinical trial(s), and lead to a first-in-class drug that inhibits the function of a unique molecular target (caPCNA) expressed exclusively by cancer cells, (including SCLC).
Genetic determinants of immune evasion by metastatic lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Metastasis is the spreading of a cancer from where it first develops to other parts of the body. Metastatic cancer is very difficult to treat because metastases can be very small and disperse all throughout the body, which means that they cannot all be surgically removed. As a result, metastatic cancer must be treated with drugs. However, the drugs we currently have to treat metastatic cancer are not very effective. Indeed, metastasis causes the majority of all cancer deaths, including lung cancer, which is itself the most frequent cause of cancer deaths in the world. Accordingly, there is a great need to develop a better understanding of metastatic cancer to enable the development of new therapies to treat cancers once they have metastasized. One promising approach is immunotherapy, which involves turning the body’s own immune system against a cancer. However, developing immunotherapies against lung cancer first demands a better understanding of how tumor are able to evade the immune system, so that we can figure out how to bring metastatic cancer out of hiding. In this project, I will use models of lung cancer metastasis in mice in which I can simultaneously test many different genes that cancer cells might be using to enable immune evasion. By labeling each cell in a way that allows me to track which gene is turned off, I can look for which cells are able to grow in metastatic sites, and thereby figure out which genes are important for metastatic growth in different organs. Furthermore, I will perform experiments where metastatic cancer cells either do or do not encounter an immune response designed to target them. These results will uncover genes that are crucial for allowing these cancer cells to avoid elimination by the immune system. This knowledge could be critical for the development of future therapies that use the immune system to eliminate metastatic cancer, no matter where it has spread.
Folsomia quadrioculata
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Folsomia
Folsomia quadrioculata

description: Folsomia quadrioculata (Tullberg, 1871)
– Isotoma quadrioculata Tullberg, 1871: 152.
CE, TE, WA, EA: Cox 1982; GI: Cox 1982; Yoosefi Lafooraki et al. 2020b; MAZ: Yoosefi Lafooraki et al. 2020b; GO: Yoosefi Lafooraki et al. 2020b; IL: Bazgir & Mirab-balou 2019; Shayanmehr et al. 2019; NK: Mehrafrooz Mayvan et al. 2022a; KS: Amiri & Kahrarian 2015; Arbea & Kahrarian 2015b; Kahrarian 2015; LO: Moradi et al. 2018; KU: Ahmadi 2021; Ahmadi et al. 2023.
Ecology and habitat in Iran: soil and leaf litter under walnut orchad, oak trees and pastureland.
General distribution: Holarctic (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 43, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Spatiotemporal patterns of annual clear-cutting distribution in tropical and subtropical regions of China with time series Landsat and CCDC
Creators: name: Zhou, Mingxing
name: Li, Guiying
name: Lu, Dengsheng
name: Xu, Cong
name: Li, Zhipeng
name: Li, Dengqiu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Spatial and temporal clear-cutting distribution is an important data source for investigating forest dynamics and formulating policies related to timber production, land use, and sustainable development. Subtropical and tropical regions of China due to their favorable weather conditions for tree growth are important timber providers, but the spatial distribution of annual clear-cutting areas was unavailable. This research leveraged dense time-series Landsat images (1986–2022) and a novel approach combining Continuous Change Detection and Classification (CCDC) with Random Forest to produce the first annual 30 m resolution clear-cutting map for the China’s subtropical and tropical regions. The per-polygon approach based on the sub-compartment and field survey data was used to evaluate the developed clear-cutting product. The spatiotemporal distribution of clear-cutting areas was further analyzed along longitude and latitude as well as in different provinces. The results indicated that the combination of CCDC and Random Forest successfully detected spatial and temporal distribution of clear-cutting areas with an overall accuracy of 75.6% based on sub-compartments and 93.3% based on field polygons. The cumulative clear-cutting area between 1987 and 2021 was approximately 21.26 × 106 ha, with a mean annual clear-cutting area of 0.61 × 106 ha in China’s subtropics and tropics. About 10.24% of subtropical/tropical vegetation experienced clear-cutting and most areas (85.94%) were clear-cut once. Clear-cutting activities gradually clustered at low latitudes and moderate longitudes, represented by Guangxi Province. More frequent clear-cutting was observed during the later period (2001–2021). This research contributes to an improved understanding of forest dynamics over time at large scale, and provides scientific data to make proper decisions for forest sustainability.
Scientists and Code: Programming as a Tool
Creators: name: Berger, Caroline
name: Lutze, Matthew
name: Elmqvist, Niklas
name: Madsen, Magnus
name: Klokmose, Clemens Nylandsted
Publisher: name: Plateau Workshop
Year: 2024
Subjects: subject: Information and Computing Sciences not elsewhere classified
subject: Computer-Human Interaction
subject: FOS: Psychology
subject: Programming Languages

description: Many scientists use programming to analyze their data. In this paper, we explore the computational ecosystem of scientists and their socio-technical system of computing through a human-centered approach. By employing contextual inquiry techniques with nine scientists drawn from fields such as theoretical physics, biomedical science, and entomology, we learned that programming is a tool for scientists, and as such the output is more important than the code itself. We found that during analysis, scientists often write code to create plots, and then compare these plots to assess the match of output to their expectation. Participants used ChatGPT while coding. We also found that scientists’ programming tools and practices often limit their analysis. Finally, based on a combined human-computer interaction and programming language analysis, we identify drivers and blockers of scientists’ work. Our findings uncover opportunities for the design of programming tools and languages.
Identification of affected human metabolites and exogenous compounds in breath of vapers
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Vapes and e-cigarettes are sold as “safer” alternatives to cigarettes. Recent studies, however, have demonstrated that these devices can potentially cause damage to the airway similar to cigarette smoking – which can lead to severe lung disorders like COPD and cancer. Other studies provide evidence that vaping exposes the airway to toxins like heavy metals and carcinogens. Everybody who vapes –including those who vape THC – is potentially putting their health at major risk. But, there are relatively few studies that have observed these factors in a human populations.

 Our group is proposing a large-scale human study to investigate whether people who vape exhibit similar airway symptoms as those who smoke cigarettes. Specifically, we will target 1) biomarkers related to airway inflammation and 2) toxins such as volatile organic compounds (VOCs) and heavy metals.

 We will conduct our investigation in the collection of breath and urine samples from 600 people in the Sacramento area. We will recruit up to 100 people among six categories of smokers: 1) never smokers, 2) cigarette smokers, 3) nicotine vapers, 4) marijuana smokers, 5) THC vapers and 6) people who routinely smoke and vape. Breath is used to assess airway inflammation and toxin exposure. Urine is used to confirm exposure of nicotine, THC and heavy metals.

 This work could be one of the very first studies, and certainly one of the largest, to observe the effects of vaping on human health, providing a rich body of work regarding pulmonary health and vaping. Additionally, our investigation of affected metabolites will offer a sound foundation for future research efforts, as the sharing of our results will help researchers determine which metabolic processes likely deserve more investigation, based on the observations we will make on a human population.
Uncovering synthetic lethal interactors with TP53 mutations for therapeutic targeting
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco use is the number one risk factor for lung cancer and is linked to about 80%-90% of lung cancer deaths in the United States. Many tobacco-derived carcinogens can induce genetic mutations in lung cancer, most notably mutations in the tumor suppressor gene, TP53. The TP53 gene is mutated in over 50% of all human cancers. The presence of these mutations predisposes patients to the initiation and progression of lung cancer, and to an association with unfavorable therapeutic responses. Considering these important roles, restoration of wild-type p53 or depletion of mutant p53 is a promising strategy for treating cancer. Many approaches have been utilized to develop these therapies, but they have yet to be clinically approved. This project will identify targeted therapies that kill cancer cells whick lack the TP53 tumor suppressor gene, yet will spare normal cells. “Synthetic Lethal (SL) partners” is a terminology used to describe an innovative approach for treating lung cancer where a combination of deficiencies of two genes lead to cell death, whereas a deficiency in only one of these genes does not. This project is innovative in several ways. First, we will use a novel and well-developed data mining technique termed “Mining Synthetic Lethals (MiSL)”. This is a computer algorithm that searches human tumor DNA data to identify mutations that could be SL partners with TP53 mutations. This approach has been successfully used in leukemia studies to identify drug targets. Second, ~8000 patient samples will be computationally analyzed by MiSL, thus providing the project with great clinical relevance. Third, we will use cutting-edge genetic and cell culture technologies to verify the SL partners to TP53 mutations that are identified to confirm the accuracy of our results and ensure the success of this study. Overall, this research will contribute to the development of novel treatment strategies for lung cancer patients with TP53 mutations and identify new targets for drug development. More importantly, if this project can successfully predict and validate synthetic lethal partners of mutant p53 proteins in lung cancer, the same methodology can be applied to all the other types of cancers containing these TP53 gene mutations. This would be a great contribution that could benefit at least half of all of cancer patients.
Additional file 10: of Do ampharetids take sedimented steps between vents and seeps? Phylogeny and habitat-use of Ampharetidae (Annelida, Terebelliformia) in chemosynthesis-based ecosystems
Creators: name: Eilertsen, Mari
name: Kongsrud, Jon
name: Alvestad, Tom
name: Stiller, Josefin
name: Rouse, Greg
name: Rapp, Hans
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: 60506 Virology

description: Heatmap based on the output from Stacey showing the posterior probability of two specimens belonging to the same species. The probability matrix was calculated from the output of the Stacey analysis (see Methods – Phylogenetic analyses). Colors represents posterior probability values: 0–0.8 – blue, 0.8–0.9 – yellow, 0.9–0.95 – orange, 0.95–1 – red. Species names are abbreviated by the tree first letters of the genus and species epithet (PDF 12 kb)
Shakespeare
Creators: name: Godsey, Marjorie
Publisher: name: No Publisher Supplied
Year: 1984

description: Reviews the importance of Queen Elizabeth I in the success of theater in England in the late 1500s.  Components of Some of Shakespeare's plays are discussed in detail, e.g., Goddard's interpretation of the "quality of mercy" speech.  Other comments concern a "parish top" in Twelfth Night, the relevance of "green fields" in Henry V, and Falstaff's dinner with Master Shallow in Henry IV.
Selected women painters of this century
Creators: name: Wolohojian, Florence
Publisher: name: No Publisher Supplied
Year: 1985

description: A history of women painters, beginning with artist Lavinia Fontana of Bologna, through the impressionists, to a number of American artists of the 1900s.  Women had difficulty establishing a professional identity, faced prejudice as artists, and were mostly seen as models, wives and mothers of artists.
Additional file 10: of Do ampharetids take sedimented steps between vents and seeps? Phylogeny and habitat-use of Ampharetidae (Annelida, Terebelliformia) in chemosynthesis-based ecosystems
Creators: name: Eilertsen, Mari
name: Kongsrud, Jon
name: Alvestad, Tom
name: Stiller, Josefin
name: Rouse, Greg
name: Rapp, Hans
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Virology

description: Heatmap based on the output from Stacey showing the posterior probability of two specimens belonging to the same species. The probability matrix was calculated from the output of the Stacey analysis (see Methods – Phylogenetic analyses). Colors represents posterior probability values: 0–0.8 – blue, 0.8–0.9 – yellow, 0.9–0.95 – orange, 0.95–1 – red. Species names are abbreviated by the tree first letters of the genus and species epithet (PDF 12 kb)
Role of Perm1, a novel mitochondrial regulatory protein in cardiac ischemia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is a major risk factor for cardiovascular diseases. It increases the risk of atherosclerosis which causes plaque to build up in artery walls, including those which supply heart muscle. When plaque narrows vessels in the heart, it can restrict blood flow to the heart and lead to angina (chest pain) when the oxygen requirements of the heart outstrip that supplied by the blood vessels. In addition, when a plaque ruptures, it can trigger a blood clot to be formed, leading to total occlusion of a coronary (heart) vessel, causing a heart attack, known as a myocardial infarction (MI). With MI irreversible death of heart muscle cells occurs, and also heart rhythm can be so disturbed that the heart cannot pump adequately, leading often to sudden and immediate death. Therefore, finding new ways to protect heart from decreased blood flow will help patients suffering from tobacco-related coronary heart disease.

 Mitochondria, which are small organelles inside heart muscle cells, are responsible for energy production that is essential for normal heart function. When mitochondrial function is disturbed, it can exacerbate heart muscle cell death. To date, emerging evidence shows that reduced blood supply (ischemia) can cause mitochondrial dysfunction, leading to heart muscle cell death and heart dysfunction. In the proposed project, we will study the role of Perm1, a novel mitochondrial regulator, in ischemic injury, by using genetically engineered mouse models. Our hypothesis is that Perm1 protein protects heart muscle cells from the damage they can incur with decreased blood supply. By using gene manipulations, we have made mice with increased and decreased Perm1 expression in the heart. We will use these mice to study the function of Perm1 in heart. In addition, we will also study the potential mechanism(s) by which Perm1 protects the heart from the damage caused by a decreased blood supply. Long range, we hope our research will lead to identification of potential therapeutic target(s) for treating the consequences of tobacco or tobacco-related product induced coronary artery disease and resultant heart disease.
Anostracans muddy the water: Anostracans from North American lakes show unclear phylogenetic relationships between taxa, and distinctive dispersal patterns
Creators: name: Lukić, Dunja
name: Lejeusne, Christophe
name: Sánchez-Fontenla, Javier
name: Bidwell, Mark T.
name: Green, Andy J.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Dispersal is essential for all organisms to enable colonization of new areas. Like many other aquatic invertebrates, Anostraca (Crustacea) disperse passively as dormant fertilized eggs. Here, we first study the genetic diversity of Branchinecta fairy shrimps (identified morphologically as B. readingi) inhabiting lakes in Saskatchewan and British Columbia, Canada. Secondly, we attempt to reconstruct the phylogeny and dispersal events that explain their genetic distribution. Finally, we compare genetic diversity and distribution of Branchinecta sp. and Artemia franciscana, the two anostracans inhabiting the Saskatchewan lakes but with different salinity niches. To this aim, we sequenced CO1 and 16S gene fragments of the Branchinecta individuals collected from eight Saskatchewan lakes. We found a relatively high number of haplotypes for both markers (79 in CO1 and 76 in 16S) in Branchinecta from Saskatchewan. Three genetic clades at the CO1 gene region were found in Saskatchewan Branchinecta, with one of these clades being widely recorded previously in the USA (but described as B. mackini). In contrast, 54 CO1 haplotypes were previously recorded in A. franciscana in Saskatchewan for which all CO1 sequences belonged to one genetic clade. This suggests that Branchinecta sequences might be originating from several distinct Ice Age refugia, contrary to A. franciscana which might be originating from a single refuge. High density of suitable habitats (>100,000 lakes in Saskatchewan), weak priority effects and frequent dispersal events could explain high genetic diversity found in the studied Branchinecta. However, we found no genetic support for a distinction between B. readingi and B. mackini.
Engineering Extracellular Vesicles for Cardiovascular Repair and Regeneration
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Coronary artery disease (CAD) is a leading cause of mortality and morbidity in the United States. CAD is characterized by the narrowing, hardening, and blockage of the coronary arteries as a result of plaque deposition on vessel walls. Though plaque buildup can be attributed to many causes, such as diet, genetics, and lack of exercise, it is greatly exacerbated by tobacco smoking. Chemicals found in smoke have been found to trigger endothelial cell (EC) dysfunction and immune cell activation, both of which contribute to plaque formation. Left untreated, complete occlusion of the arteries leads to limited blood flow to the heart, which can cause potentially fatal heart attacks. Fortunately, surgical interventions like balloon angioplasty have been developed restore proper blood flow. However, this procedure damages the EC lining of the vessel wall and exposes the underlying collagen. This damage attracts platelets, which adhere quickly to the exposed collagen and initiate a series of biological reactions that leads to further vessel damage. This begins a progression of cardiac failure that eventually culminates in death. As such, there is a critical need to inhibit platelet adhesion and promote reendothelialization in the coronary arteries following angioplasty procedures in order to protect the heart from further damage.

 We have shown extracellular vesicles (EVs), nanovesicles secreted by cells to mediate critical cell function, to be an excellent nanotherapeutic for regenerative medicine. Specifically, EVs derived from endothelial progenitor cells (EPC) facilitate angiogenesis and vascularization. However, their clinical application has been greatly hindered by the inefficiencies of EV isolation, as current methods lead to very low, impure, and heterogeneous EV yields. Therefore, we propose to synthesize an engineered nanotherapeutic that can mimic the functions of EPC EVs but without the aforementioned drawbacks to be used to promote vascular repair and regeneration. Our engineered EV will be designed for dual functions: (1) self-directed collagen binding to prevent platelet adhesion, and (2) promotion of reendothelialization and vascular regeneration. Successful design and validation of this engineered EV will have important implications for improving outcomes following CAD and reduce the devastating impacts of tobacco smoking on cardiovascular health.
Our affluent society: Food
Creators: name: Mehrhof, Katharine
Publisher: name: No Publisher Supplied
Year: 1970

description: Brief summary of the revolution in agriculture, products and packaging of food and equipment for storage and cooking. By 19&0, electric stoves and two-door refrigerators had been introduced and bags for garbage disposal were being extolled. Cake mixes are mentioned, including one called "Flako" which was made in New Brunswick, N.J.
Relationship between Galectin-1 and Radiation in Mobilizing MDSC in Head and Neck Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Head and neck cancers (HNC), especially those related to tobacco and alcohol use, have extremely poor prognosis, despite of aggressive treatment with surgery, radiation, chemotherapy and immune therapy. Studies have shown that the immune system plays a critical role in eliminating HNC cells. Unfortunately, HNC cells produce factors that can directly increase the number myeloid-derived suppressor cells (MDSCs), which then suppress the activity of other immune cells against HNC and help cancer cells to spread to other organs. In addition, the presence of MDSCs in the blood and in the tumor has been linked to treatment failure after radiation and immune therapy. Radiation treatment by itself has been shown to increase MDSC level in the blood. Therefore, investigating tumor factors that increase MDSC level or function is crucial for developing new therapy against aggressive HNC. We have data showing that HNC produce galectin -1 (Gal-1) which can attract MDSCs into the blood and to the tumor, and that blocking this protein significantly reduces the number of MDSCs and lung metastases. Based on our preliminary data, we hypothesize that radiation induces Gal-1 production from HNC, that then leads to MDSC expansion in the blood and in the tumor, where they prevent T cells from killing tumor cells. We believe that strategies to inhibit Gal-1 can decrease the level MDSC in the tumor and blood and would enhance the effectiveness of radiation and immune therapy against HNC.