cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
What We Love Most: Blue Lion and Other Stories
Creators: name: Kenny, Jackie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: This collection of short stories strives to highlight the beauty of the natural world and show how people are intimately interconnected with all of the elements around them. The stories aim to explore the different types of consciousness, love, and wonder that can be found in the most unexpected of places. Ultimately, the author wishes the collection, by being framed in the odd light of magical realism, to inspire hope.
A Flexible and Efficient Algorithmic Framework for Constrained Matrix and Tensor Factorization
Creators: name: Huang, Kejun
name: Sidiropoulos, Nicholas D.
name: Liavas, Athanasios P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Optimization and Control (math.OC)
subject: Computation (stat.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We propose a general algorithmic framework for constrained matrix and tensor factorization, which is widely used in signal processing and machine learning. The new framework is a hybrid between alternating optimization (AO) and the alternating direction method of multipliers (ADMM): each matrix factor is updated in turn, using ADMM, hence the name AO-ADMM. This combination can naturally accommodate a great variety of constraints on the factor matrices, and almost all possible loss measures for the fitting. Computation caching and warm start strategies are used to ensure that each update is evaluated efficiently, while the outer AO framework exploits recent developments in block coordinate descent (BCD)-type methods which help ensure that every limit point is a stationary point, as well as faster and more robust convergence in practice. Three special cases are studied in detail: non-negative matrix/tensor factorization, constrained matrix/tensor completion, and dictionary learning. Extensive simulations and experiments with real data are used to showcase the effectiveness and broad applicability of the proposed framework.
Predicting the Lifetime of Superlubricity
Creators: name: Wang, Anle
name: He, Qichang
name: Xu, Zhiping
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The concept of superlubricity has recently called upon notable interest after the demonstration of ultralow friction between atomistically smooth surfaces in layered materials. However, the energy dissipation process conditioning the sustainability of superlubric state has not yet been well understood. In this work, we address this issue by performing dynamic simulations based both on full-atom and reduced Frenkel-Kontorova models. We find that the center-of-mass momentum autocorrelation of a sliding object can be used as an indicator of the state of superlubricity. Beyond a critical value of it, the sliding motion experiences catastrophic breakdown with a dramatically high rate of energy dissipation, caused by the inter-vibrational-mode coupling. By tracking this warning signal, one can extract heat from modes other than the translation to avoid the catastrophe and extend the lifetime of superlubricity. This concept is demonstrated in double-walled carbon nanotubes based nanomechanical devices with indicator-based feedback design implemented.
Identifying a Cellular Mechanism of Cardiac Interventricular Septal Formation
Creators: name: Tarallo, Caroline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Congenital heart disease (CHD), defined as any abnormality of the heart’s anatomical structure present at birth, comprises almost one third of all major abnormalities at birth with 1.35 million babies born worldwide with lethal CHD each year. One third of CDH cases involve ventricular defects, occurring when the interventricular septum (IVS) does not fully develop. The morphological events surrounding formation of the IVS are well known, as current evidence supports a model where a muscular septum grows up from the myocardial wall and involves the interactions between two populations of cells, called the first and second heart fields. However, the molecular processes governing the integration and contribution of these two populations of cells to the septum and the role of the transcription factor CASZ1 are unknown. The Cre Recombinase system, driven by heart field specific promoters, and a novel mechanism of cell fate mapping in a reporter mouse line were used to elucidate the location of second heart field cells in mice on day 13.5 of embryonic development. Analysis of confocal microscopy Z-stack images of immunostained and sectioned heart tissue revealed that in wild-type Casz1 mice, cells originating from the second heart field are found uniformly throughout the septum. In contrast, there is a marked reduction in the number of second heart field derived cells in the IVS of Casz1 heterozygous and null mice in addition to sequestering of those cells to the right half of the septum. Additionally, Casz1 knockout mice exhibit noticeably smaller hearts. Identifying contributing cells to the IVS and the impact that CASZ1 has on the integration of those cells will lead to a deeper understanding of the mechanism by which the IVS forms in the hopes that this could be manipulated in future treatment options for CHD.
A Monte Carlo Study of Pairwise Comparisons
Creators: name: Herman, M. W.
name: Koczkodaj, W. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Other Computer Science (cs.OH)
subject: FOS: Computer and information sciences

description: Consistent approximations obtained by geometric means ($GM$) and the principal eigenvector ($EV$), turned out to be close enough for 1,000,000 not-so-inconsistent pairwise comparisons matrices. In this respect both methods are accurate enough for most practical applications. As the enclosed Table 1 demonstrates, the biggest difference between average deviations of $GM$ and $EV$ solutions is 0.00019 for the Euclidean metric and 0.00355 for the Tchebychev metric. For practical applications, this precision is far better than expected. After all we are talking, in most cases, about relative subjective comparisons and one tenth of a percent is usually below our threshold of perception.
Creation of Augmented Reality Version of Neat Space's Products
Creators: name: Lucero, Trisha Joie D.
Publisher: name: Zenodo
Year: 2022
Subjects: Virtual reality; Extended reality

description: This project is a collaboration with Neat Space, an online furniture shop established in mid-2020. Their store is well- known for selling storage solutions such as floating shelves, racks and rolling carts, their chosen products, which include the "Heiho shelf set" the " Ozukai floating shelf", and the " Nordic Cube Rack", will be converted into 3-D models that can be viewed using Adobe Aero application. This project aims to develop an Augmented Reality prototype for an existing online store and test it with the store's potential market. The researcher hopes to learn about the impact on potential customers if they will be able to visualize products from online stores like Neat Space not only through images but also through augmented reality.
title: Embolization of large pulmonary artery mycotic pseudo-aneurysm causing massive haemoptysis – a life-saving therapeutic option
Creators: name: O'Mahony, Johnny
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Interventional radiology
subject: Interventional vascular
subject: Lung
subject: Haemorrhage
subject: Infection
subject: Complications
subject: Embolisation
subject: Aneurysms
subject: Clinical Cases

description: Clinical History: A 35-year-old male patient initially presented to the emergency department of our institution, a tertiary referral, university teaching hospital, with symptoms of respiratory sepsis, including tachycardia, hypotension, pyrexia, hypoxia and a productive cough. This occurred in the context of active intravenous drug use, and chronic hepatitis C infection. The patient was initially treated with antibiotics and fluid resuscitation.

description: 35 years, male
On the Massless Vector Fields in a Rindler Space
Creators: name: Soldati, Roberto
name: Specchia, Caterina
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the quantum theory of the mass-less vector fields on the Rindler space. We evaluate the Bogoliubov coefficients by means of a new technique based upon the use of light-front coordinates and Mellin transform. We briefly comment about the ensuing Unruh effect and its consequences.
description: 17 pages, no figures
Homo sapiens Transcriptome or Gene expression
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: transcriptome
Multiisolate

description: To investigate RNA editing in hepatocellular carcinoma (HCC), we deeply sequenced 18 RNA samples from 9 HCC patients to identify RNA editing events. In our sample cohort, we find 26,982 ± 12,574 (Mean ± SD) editing sites with 89.51% ± 2.71% (Mean ± SD) canonical A->G edits in each sample. Comparing the difference between normal and tumor samples of each patient, we find 7 non-synonymous specific editing events including 4 tumor-specific edits and 3 normal-specific edits in CDS region, as well as 292 edits showing variance in editing degree. Meanwhile, the significant expression changes of 150 genes being associated with RNA editing are found in tumor, including 3 of 4 most significant genes are cancer or disease related. All these findings indicate that the RNA editing modification may play a role in the development of hepatocellular carcinoma.
3D magnetic field configuration of small-scale reconnection events in the solar plasma atmosphere
Creators: name: Shimizu, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The outer solar atmosphere, i.e., the corona and the chromosphere, is replete with small energy-release events, which are accompanied by transient brightening and jet-like ejections. These events are considered to be magnetic reconnection events in the solar plasma, and their dynamics have been studied using recent advanced observations from the Hinode spacecraft and other observatories in space and on the ground. These events occur at different locations in the solar atmosphere, and vary in their morphology and amount of the released energy. The magnetic field configurations of these reconnection events are inferred based on observations of magnetic fields at the photospheric level. Observations suggest that these magnetic configurations can be classified into two groups. In the first group, two anti-parallel magnetic fields reconnect to each other, yielding a 2D emerging flux configuration. In the second group, helical or twisted magnetic flux tubes are parallel or at a relative angle to each other. Reconnection can occur only between anti-parallel components of the magnetic flux tubes and may be referred to as component reconnection. The latter configuration type may be more important for the larger class of small-scale reconnection events. The two types of magnetic configurations can be compared to counter-helicity and co-helicity configurations, respectively, in laboratory plasma collision experiments.
description: 19 pages, 9 figures, Accepted for publications in Physics of Plasmas
The whole genome sequencing ，Lactobacillus shenzhenensis is a kind of probiotics
Creators: name: BGI
Publisher: name: CNGB
Year: 2013
Subjects: Genome sequencing and assembly
Multiisolate

description: Lactobacillus shenzhenensis LY-73 is a strain isolated from a fermented goods, This organism produces bacteriocins which have inhibitory effects on pathogenic microorganisms. Lactobacillus shenzhenensis LY-73 have been extensively studied for its effectiveness as a probiotics to maintain the balance of the gut microbial flora and stimulate the intestinal immune system.
Target-aware Bayesian inference via generalized thermodynamic integration
Creators: name: Llorente, F.
name: Martino, L.
name: Delgado, D.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Computation (stat.CO)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In Bayesian inference, we are usually interested in the numerical approximation of integrals that are posterior expectations or marginal likelihoods (a.k.a., Bayesian evidence). In this paper, we focus on the computation of the posterior expectation of a function $f(\x)$. We consider a \emph{target-aware} scenario where $f(\x)$ is known in advance and can be exploited in order to improve the estimation of the posterior expectation. In this scenario, this task can be reduced to perform several independent marginal likelihood estimation tasks. The idea of using a path of tempered posterior distributions has been widely applied in the literature for the computation of marginal likelihoods. Thermodynamic integration, path sampling and annealing importance sampling are well-known examples of algorithms belonging to this family of methods. In this work, we introduce a generalized thermodynamic integration (GTI) scheme which is able to perform a target-aware Bayesian inference, i.e., GTI can approximate the posterior expectation of a given function. Several scenarios of application of GTI are discussed and different numerical simulations are provided.
Inducible Expression of the CRTC1-MAML2 Fusion Oncogene for Modeling Mucoepidermoid Carcinoma Cell Phenotypes
Creators: name: Aghera, Shaily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Among salivary gland cancers, mucoepidermoid carcinoma (MEC) is the most common malignant tumor type. MEC is frequently characterized by a recurrent chromosomal translocation that fuses chromosomes 11 and 19, resulting in a novel CRTC1/MAML2 (C1/M2) fusion product composed of the CREB-binding domain of CRTC1 and the transcriptional activation domain of MAML2. It is not known what the downstream targets of C1/M2 are past PGC-1α4 and IGF-1. To study the acute effects of C1/M2 induction on transcriptional and signal transduction circuits, we created a tool to inducibly express C1/M2 in an inducible manner. Through restriction enzyme cloning, we created a plasmid where the expression of C1/M2 is under the control of a doxycycline-inducible promoter. We then transduced this plasmid into a C1/M2-negative cell line and performed qPCR and Western blotting assays in the presence or absence of doxycycline to analyze C1/M2 expression. qPCR analyses demonstrated that doxycycline treatment increased C1/M2 transcript levels by approximately 15-fold in the doxycycline-inducible cells. This construct will first be used to determine how it affects the expression of known C1/M2 target genes, including PGC-1α4 and IGF-1. Long-term goals include the analysis of other C1/M2-regulated pathways and discovering what additional target genes are regulated by C1/M2 and testing whether they drive cancerous transformation in MEC.
Large-N(c) limit reduces the number of independent few-body parity-violating low-energy constants in pionless effective field theory
Creators: name: Schindler, Matthias R.
name: Springer, Roxanne P.
name: Vanasse, Jared
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The symmetries of the Standard Model dictate that for very low energies, where nucleon dynamics can be described in terms of a pionless effective field theory, the leading-order parity-violating nucleon-nucleon Lagrangian contains five independent unknown low-energy constants (LECs). We find that imposing the approximate symmetry of QCD that appears when the number of colors N(c) becomes large reduces the number of independent LECs to two at leading order in the combined pionless effective field theory and large-N(c) expansions. We also find a relation between the two isoscalar LECs in the large-N(c) limit. This has important implications for the number of experiments and/or lattice calculations necessary to confirm this description of physics.
description: 11 pages, corrected missing factors of $\sin^2 \theta_W$; conclusions unchanged
microRNA -19b is a sex-dependent regulator of posttraumatic stress symptoms and widespread pain
Creators: name: Rueckeis, Cathleen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Posttraumatic widespread pain (PTWP) and posttraumatic stress symptoms (PTSS) are frequent forms of trauma that occur at different rates in women and men. Genetic approaches to study pathways using model organisms and mutants have identified hundreds of genes correlated with PTWP/PTSS. Our lab sought to identify microRNAs (miRNAs) that contribute to sex-dependent differences in vulnerability to these outcomes. In the current study, we first identified miRNA that are predicted to regulate PTWP/PTSS genes using Monte Carlo simulations. We found that the most significant miRNA predicted to target PTWP/PTSS genes was miR-19b, a microRNA that has been shown previously to be regulated in response to estrogen and stress exposure. Next, we assessed whether miR-19b expression predicts PTWP/PTSS in a cohort of individuals experiencing motor vehicle collision, one of the most common forms of trauma currently experienced by Americans. Logistic regression demonstrated a sex dependent relationship between initial miR-19b levels following motor vehicle collision and later development of PTWP/ PTSS. The sex-dependent expression of miR-19b was also observed in a rat model of single prolonged stress, which is thought to be analogous to PTSS. We found miR-19b to be regulated by 17-β-estradiol in rat dorsal root ganglion neurons and amygdala, which are neural tissues commonly implicated in PTSS. The potential importance of miR-19b to PTWP/PTSS pathogenesis is highlighted by results showing that miR-19b can directly bind a number of pain and PTSS associated transcripts including circadian rhythm pathway genes. Together, our results suggest that miR-19b plays a regulatory role in PTWP and PTSS development following trauma/stress exposure. Thus, the level of miR-19b expression following motor vehicle collision may predict PTWP/PTSS and enable preventative treatment.
Dammann et al_Biol Lett_Supplementary information from Longevity of a solitary mole-rat species and its implications for the assumed link between sociality and longevity in African mole-rats (Bathyergidae)
Creators: name: Dammann, P.
name: Šaffa, G.
name: Šumbera, R.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Details on study species, capture, husbandry, analysis of growth, and causal assumptions for the DAG construction
Can single-reference coupled cluster theory describe static correlation?
Creators: name: Bulik, Ireneusz W.
name: Henderson, Thomas M.
name: Scuseria, Gustavo E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: While restricted single-reference coupled cluster theory truncated to singles and doubles (CCSD) provides very accurate results for weakly correlated systems, it usually fails in the presence of static or strong correlation. This failure is generally attributed to the qualitative breakdown of the reference, and can accordingly be corrected by using a multi-determinant reference, including higher-body cluster operators in the ansatz, or allowing symmetry breaking in the reference. None of these solutions are ideal; multi-reference coupled cluster is not black box, including higher-body cluster operators is computationally demanding, and allowing symmetry breaking leads to the loss of good quantum numbers. It has long been recognized that quasidegeneracies can instead be treated by modifying the coupled cluster ansatz. The recently introduced pair coupled cluster doubles (pCCD) approach is one such example which avoids catastrophic failures and accurately models strong correlations in a symmetry-adapted framework. Here we generalize pCCD to a singlet-paired coupled cluster model (CCD0) intermediate between coupled cluster doubles and pCCD, yielding a method that possesses the invariances of the former and much of the stability of the latter. Moreover, CCD0 retains the full structure of coupled cluster theory, including a fermionic wave function, antisymmetric cluster amplitudes, and well-defined response equations and density matrices.
Antibody Functionalization onto Microraft Arrays for Nonadherent Cell Capture and Sorting
Creators: name: Kantesaria, Saurin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Microraft arrays are cell-sorting devices the Allbritton lab has developed; they consist of a grid of thousands of transparent, magnetic cell carriers or “microrafts” embedded in a polymer membrane. Cells can be cultured on these devices and microrafts with cells can be dislodged from below using a microneedle. The dislodged microrafts can be magnetically manipulated for various downstream biological applications and bioassays. While microraft arrays can easily sort adherent cell lines such as cancer and stem cells, many highly desirable samples for cell sorting applications include nonadherent cells such as lymphocytes and other blood cells. These cell types do not attach to microrafts during culture and cannot be sorted efficiently or accurately with the current microraft platform. To enable flexible nonadherent cell sorting capable of complex phenotypic sorting criteria, a nonadherent cell capture method was investigated by attaching cell-specific antibodies onto microrafts to adhere cells to the surface. Methods of antibody attachment, such as adsorption and covalent attachment of recombinant Protein A/G (Pr A/G) and biotin amplification on microrafts were compared using fluorescence intensity readings after attachment of fluorophore-conjugated antibody to modified surfaces. It was found that adsorption of Pr A/G yields the highest and most consistent fluorescence intensity outputs. A preliminary sorting experiment comparing the sorting efficiency of Kasumi-3 (CD34+) and K562 (CD34-) cells on microrafts with anti-CD34 attached to Pr A/G-treated microrafts and plain, plasma-treated microrafts showed high cell sorting efficiencies (13.0% Kasumi-3 cells sorted, Control; 57.1% Kasumi-3 cells sorted, Pr A/G) and high sorting specificity (0.0% K562 cells sorted, Pr A/G; 57.1% Kasumi-3 cells sorted, Pr A/G) with this method.
EGFRvIII and Pten Deletion Mutations Influence Genotype-Dependent Kinome Activation in Immortalized Murine Astrocyte Models of Glioblastoma
Creators: name: Butler, Madison
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Glioblastoma (GBM) is the most common malignant primary brain tumor. Receptor tyrosine kinase (RTK) pathways are frequently mutated in GBM, including alterations in the RTK Epidermal Growth Factor Receptor (EGFR). Moreover, EGFR variant III (EGFRvIII) is the most common activating mutation in GBM. Given its frequency, specificity, and role in promoting gliomagenesis, EGFR dysfunction is a prime target for drug treatment. However, multiple resistance mechanisms, such as co-occurrence of EGFRvIII and deletion of the tumor suppressor PTEN, prevent effective treatment via activation of alternate kinase pathways. To observe the differential kinase activation involved in EGFRvIII- and PTEN loss- driven gliomagenesis and identify potential kinase targets for dual therapy, we examined immortalized murine astrocytes derived from non-germline genetically engineered mouse models expressing four core genotypes: wild-type EGFR + wild-type Pten (C), wild-type EGFR + Pten deletion (CP), EGFRvIII + wild-type Pten (CEv3), and EGFRvIII + Pten deletion (CEv3P). We used RNA sequencing and multiplexed inhibitor bead affinity chromatography and mass spectrometry (MIB-MS) to determine the baseline transcriptomes and kinomes of each genotype. We determined that cell lines exhibited genotype-dependent baseline RNA expression and kinase activity as a result of EGFRvIII and/or Pten deletion relative to C astrocytes and across genotypes. We observed several differentially-activated kinases that represent potential targets for dual treatment with EGFR TKI. We are currently examining changes in the kinome profile of each cell line after both acute and chronic treatment with tyrosine kinase inhibitors (TKI). These results will help define the kinase networks involved in tumor development and resistance and may aid in the identification of potential personalized combination therapy with EGFR TKI for GBM patients.
Fluid-rock interaction at the backstop to the Mediterranean Ridge Accretionary Complex South of Crete : R/V SONNE Cruise Report SO278 : Emden (Germany), 12.10.2020 - Emden (Germany), 01.12.2020 : FRINGE
Creators: name: Bohrmann, Gerhard
name: Ahrlich, Frauke
name: Antoniou, Dimitra
name: Behrendt, Nele
name: Innocentini, Simone
name: Coulibaly, Ousmane
name: Eijsink, Agathe
name: Feddersen, Greta
name: Gaide, Stefanie
name: Kaul, Norbert
name: König, Tabea
name: Krahl, Julia
name: Kürzinger, Victoria
name: Lenius, Sven
name: Malnati, Janice
name: Marschall, Lara
name: Niederbockstruck, Bryan
name: Porrmann, Simon
name: Rau, Svenja
name: Römer, Miriam
name: Schillai, Sophia
name: Spiesecke, Ulli
name: Streuff, Katharina
name: Tseng, Yiting
name: Vejzovic, Ines
name: Von Wahl, Till
name: Warnken, Niklas
name: Witzleb, Antonia
Publisher: name: Universität Bremen
Year: 2022
Subjects: subject: Forschungsreise
subject: 550

description: The research cruise to the Eastern Mediterranean (GPF-18-2-40) originally planned on RV METEOR was relocated to RV SONNE (Fig. 1.2) due to the reduced number of scientists as part of the corona pandemic. The main objective of the Bremen Ocean Cluster expedition (DFG, EXC2077) was to investigate the interactions between the seabed and ocean water in Greek waters, whereby the plate tectonic constellation of a broad collision zone represents a special tectonic drive. A secondary goal was the sampling of the Sartori mud volcano, which is being processed in Italian waters as part of a separate DFG project and for which the GPF granted an additional permit for ship time (GPF 20-1_054). The expedition began on 12 October in Emden/Germany and ended on 01 December 2020, in Emden. Investigations on mud volcanoes were carried out divided into 3 working areas (Fig. 1.1, the Sartori mud volcano in the Calabrian arc, the so-called Cobblestone Area, the Olimpi mud volcano field including the United Nation Ridge). With the MARUM AUV SEAL (Fig. 1.3) 11 dives were successfully carried out to create high-resolution detailed maps of certain seafloor structures. A total of 38 gravity cores (Fig. 1.4), 30 multicorers (Fig. 1.5) and 4 minicorers were used for sampling sediments and 6 CTD stations for sampling methane in the water column. Furthermore, 10 profiles were carried out with the heat flow lance and 5 observation profiles with the on-board OFOS. In four different provinces, 16 mud volcanoes were examined, 10 of which are characterized by pore waters that show a distinct freshening, while three mud volcanoes, Napoli, Heraklion and Gelendzhik, are characterized by very high salt concentrations. The salt accumulations in these structures are derived from the Messinian salt deposits in the subbed, from which salty brines arise through subrosion, which interact in various ways with the mud volcanoes. The study areas were selected based on preliminary surveys and morphological structures and increased backscatter patterns from multibeam mapping carried out over 3580 nautical miles in Italian and Greek waters.
การพัฒนาทักษะกีฬาฟุตบอลและความคิดสร้างสรรค์ของนักเรียนประถมศึกษาโดยใช้การเรียนรู้โดยสมองเป็นฐาน
Creators: name: บุญโต ศรีจันทร์
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: ทักษะกีฬาฟุตบอล
ความคิดสร้างสรรค์
การเรียนรู้โดยสมองเป็นฐาน

description: Academic Journal of Thailand National Sports University, 14, 3, 201 - 212
K-Ras Drug Discovery: Development of G12C Mutant-Specific Inhibitors
Creators: name: Chaia, Angelo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Ras proteins are small (~21kD) guanine nucleotide binding proteins (G-proteins) that are part of a large (>150) superfamily of GTPases. Three (K-, H- and N-) Ras isoforms encode 4 Ras proteins. They function as molecular switches, that cycle between inactive GDP- and active GTP-bound states to control cellular growth.  About 30% of all cancers contain single point mutations in Ras that induce its chronic activation.1 Of the three isoforms, K-Ras is mutated at the highest frequency in human cancer. The K-RasG12C mutation, in particular, is found in about 33% of non-small cell lung carcinomas.2 Recent studies have targeted the K-RasG12C mutation for drug discovery utilizing cysteine-reactive small molecules, which will soon be the first Ras inhibitors to move to stage-1 clinical trials.3 This project investigated a new small molecule candidate, naringenin, that binds in the same pocket as the K-RasG12C inhibitors. The binding site and affinity of naringenin to K-RasG12C was evaluated using 2D Heteronuclear Single Quantum Coherence (HSQC) spectroscopy. Our findings indicate that naringenin binds weakly to an allosteric pocket near the switch-II region of K-RasG12C and induces changes in guanine nucleotide exchange. The addition of an acrylate group to naringenin allowed for an irreversible bond to form between naringenin and cysteine-12 to overcome low affinity. This “warhead” inhibitor candidate can be modified further to bind tighter within the allosteric pocket of Ras. Furthermore, we find that a subset of selective estrogen receptor modulators (SERMs) which share similar characteristics to naringenin, bind in the same pocket, and may provide for an additional direction for Ras drug development.
Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Creators: name: Phalake, Satish
S.
name: B. Somvanshi, Sandeep
name: TOFAIL, SYED ANSAR
name: Thorat, Nanasaheb
name: Khot, Vishwajeet M.
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Localized heat generation from manganese iron oxide nanoparticles (MIONPs) conjugated with chemotherapeutics under the exposure of an alternating magnetic field (magneto-chemotherapy) can revolutionize targeted breast cancer therapy. On the other hand, the lack of precise control of local temperature and adequate MIONP distribution in laboratory settings using the conventional two-dimensional (2D) cellular models has limited its further translation in tumor sites. Our current study explored advanced 3D in vitro tumor models as a promising alternative to replicate the complete range of tumor characteristics. Specifically, we have focused on investigating the effectiveness of MIONP-based magneto-chemotherapy (MCT) as an anticancer treatment in a 3D breast cancer model. To achieve this, chitosan-coated MIONPs (CS–MIONPs) are synthesized and functionalized with an anticancer drug (doxorubicin) and a tumor-targeting aptamer (AS1411). CS–MIONPs with a crystallite size of 16.88 nm and a specific absorption rate (SAR) of 181.48 W g−1 are reported. In vitro assessment of MCF-7 breast cancer cell lines in 2D and 3D cell cultures demonstrated anticancer activity. In the 2D and 3D cancer models, the MIONP-mediated MCT reduced cancer cell viability to about 71.48% and 92.2%, respectively. On the other hand, MIONP-mediated MCT under an AC magnetic field diminished spheroids’ viability to 83.76 ± 2%, being the most promising therapeutic modality against breast cancer.
Quantum phase transition triggering magnetic BICs in graphene
Creators: name: Guessi, L. H.
name: Marques, Y.
name: Machado, R. S.
name: Kristinsson, K.
name: Ricco, L. S.
name: Shelykh, I. A.
name: Figueira, M. S.
name: de Souza, M.
name: Seridonio, A. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Graphene hosting a pair of collinear adatoms in the phantom atom configuration has pseudogap with cubic scaling on energy, $Δ\propto|\varepsilon|^{3}$ which leads to the appearance of spin-degenerate bound states in the continuum (BICs) [Phys. Rev. B 92, 045409 (2015)]. In the case when adatoms are locally coupled to a single carbon atom the pseudogap scales linearly with energy, which prevents the formation of BICs. In this Letter, we explore the effects of non-local coupling characterized by the Fano factor of interference $q_{0},$ tunable by changing the slope of the Dirac cones in the graphene band-structure. We demonstrate that three distinct regimes can be identified: i) for $q_{0}q_{c2}$ the cubic scaling of the pseudogap with energy $Δ\propto|\varepsilon|^{3}$ characteristic to the phantom atom configuration is restored and the phase with non-magnetic BICs is recovered. The phase with magnetic BICs can be described in terms of an effective intrinsic exchange field of ferromagnetic nature between the adatoms mediated by graphene monolayer. We thus propose a new type of quantum phase transition resulting from the competition between the states characterized by spin-degenerate and magnetic BICs.
Testimonia publica, kalls- og kollasbrev for prester i Trondhjems stift
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 0

description: Brev for prester i Trondhjems stift, med kandidaternes inntegnete vidimasjon og biskop Bredals egenhendige anmerkninger, såsom når en kandidat er blitt ordinert etc.
โปรแกรมกิจกรรมโดยประยุกต์แนวคิดการจัดการศึกษาแบบเชิญชวนที่มีต่อความตระหนักรู้และการปฏิบัติเพื่อป้องกันฝุ่น PM 2.5 ของนักเรียนประถมศึกษา
Creators: name: ประภาวรินทร์ รัชชประภาพรกุล
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: โปรแกรมกิจกรรม
การจัดการศึกษาแบบเชิญชวน
ความตระหนักรู้และการปฏิบัติเพื่อป้องกันฝุ่น PM 2.5

description: Academic Journal of Thailand National Sports University, 14, 3, 213 - 222
Aureobasidium khasianum Pratibha & Prabhug. 2018, sp. nov.
Creators: name: Prabhugaonkar, Ashish
name: Pratibha, J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Fungi
Ascomycota
Dothideomycetes
Dothideales
Saccotheciaceae
Aureobasidium
Aureobasidium khasianum

description: Aureobasidium khasianum Pratibha & Prabhug., sp. nov. (Fig. 2)
MycoBank MB 828278.
 Holotype:— INDIA. Meghalaya, Khasi hills, forest near Puriang village, on decomposing fallen leaves of Wightia speciosissima (D. Don) Merr. (Paulowniaceae), 12 December 2016, coll. A. Prabhugaonkar, (holotype HCIO 52163, isotype ASSAM-AVP 109), ex-type culture NFCCI- 4275, AVP(C)-109.
 Colonies on the leaf surface circular, hairy, dark brown to black. Mycelium partly immersed in the substrate. Hyphae septate, branched, pale brown to brown, smooth-walled, 1.5–2.5 μm wide. Setae unbranched, erect, straight, dark brown, smooth, thick-walled, 80–200 × 7–10 μm. Conidiophores micronematous to semi-macronematous, mononematous, adhering to the sides of the setae and forming conidiogenous cells. Conidiogenous cells monoblastic, rarely polyblastic. Conidia monilioid arising in acropetal branched chains, fragmenting, aseptate, smooth, hyaline to pale olivaceous, 3–4 × 2–40 μm, sometimes forming a conidial mass of uneven size and shape.
Colonies on malt extract agar, fast growing, spreading, and covered with slimy masses of conidia, white when young, dark green at maturity. Mycelium forming cords of 10–15 μm or more thickness, smooth, septate, becoming brown and thick-walled. Stromata none, setae and hyphopodia absent.Arthroconidia integrated, intercalary, ellipsoidal, 2–3 × 2–7 μm. Conidiogenous cells on hyaline hyphae, phialidic, lateral, terminal or intercalary. Conidia produced simultaneously in dense groups, hyaline, smooth, one-celled, variable in shape and size, 1–4 × 2–5 μm. Secondary conidia produced by yeast like budding of primary conidia.
 Habitat/Distribution:— On fallen leaf litter of Wightia speciosissima, India.
 Etymology:— Refers to Khasi hills.
description: Published as part of Prabhugaonkar, Ashish & Pratibha, J., 2018, Aureobasidium khasianum (Aureobasidiaceae a novel species with distinct morphology, pp. 257-262 in Phytotaxa 374 (3) on page 260, DOI: 10.11646/phytotaxa.374.3.7, http://zenodo.org/record/13727144
Remote Surface Roughness Scattering in FDSOI devices with high-$κ$/SiO$_2$ gate stacks
Creators: name: Niquet, Y. M.
name: Duchemin, I.
name: Nguyen, V. -H.
name: Triozon, F.
name: Rideau, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigate remote surface scattering (RSR) by the SiO$_2$/HfO$_2$ interface in Fully-Depleted Silicon-on-Insulator (FDSOI) devices using Non-Equilibrium Green's Functions. We show that the RSR mobility is controlled by cross-correlations between the surface roughness profiles at the Si/SiO$_2$ and SiO$_2$/HfO$_2$ interfaces. Therefore, surface roughness and remote surface roughness can not be modeled as two independent mechanisms. RSR tends to enhance the total mobility when the Si/SiO$_2$ interface and SiO$_2$ thickness profiles are correlated, and to decrease the total mobility when they are anti-correlated. We discuss the implications for the high-$κ$/Metal gate technologies.
ผลการจัดการเรียนรู้พลศึกษาโดยใช้แนวคิดการกำกับตนเองที่มีต่อผลสัมฤทธิ์ทางการเรียนและความฉลาดทางอารมณ์ของนักเรียนมัธยมศึกษา
Creators: name: ปรียานุช ตันวัฒนเสรี
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: การจัดการเรียนรู้พลศึกษา
การกำกับตนเอง
ความฉลาดทางอารมณ์

description: Academic Journal of Thailand National Sports University, 14, 3, 223 - 240
ผลการฝึกตารางเก้าช่องประกอบเพลงที่มีต่อการทรงตัวและความคล่องตัวของเด็กที่มีความต้องการพิเศษแบบเรียนร่วม
Creators: name: มนเฑียร อยู่เย็น
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: ตารางเก้าช่อง
เพลง
การทรงตัว
ความคล่องตัว
เด็กพิเศษ
การเรียนรู้แบบเรียนร่วม

description: Academic Journal of Thailand National Sports University, 14, 3, 241 - 252
แนวทางสร้างเสริมสุขภาวะในการทำงานของผู้หญิงวัยทำงานจังหวัดชายแดนใต้1
Creators: name: วงศ์พัทธ์ ชูดำ
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: รูปแบบ
สุขภาวะผู้หญิงวัยทำงาน
จังหวัดชายแดนใต้

description: Academic Journal of Thailand National Sports University, 14, 3, 253 - 266
An Exploratory multi-case study of the health and wellbeing needs, relationships and experiences of health and social care service users and the people who support them at home
Creators: name: Henderson, Louise
name: Bain, Heather
name: Allan, Elaine
name: KENNEDY, CATRIONA
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Introduction: International policies and legislation set a precedence of person-centred sustainable integrated Health and Social Care (HSC) that meets the health and wellbeing needs of service users through improved experiences. However, current research focuses on service models, with fewer studies investigating experiences and needs. Methods: This qualitative multi-case [n = 7] study was co-designed with key stakeholders and aimed to explore experiences and needs of people who access and provide HSC at home. Data were collected in a regional area of Scotland (UK) via single [n = 10] or dyad [n = 4] semi-structured interviews with service users [n = 6], informal carers [n = 5] and HSC staff [n = 7] and synthesised using Interpretive Thematic Analysis. Findings: Interpersonal connections and supportive relationships were instrumental in helping all participant groups feel able to cope with their changing HSC needs and roles. They promoted reassurance, information sharing and reduced anxiety; when they were lacking, it negatively impacted upon experiences of HSC. Discussion: Promoting inter-personal connections that encourage supportive relationships between people who access and provide HSC and their communities, could promote person-centred Relationship-based care and improve HSC experiences. Conclusions: This study identifies indicators for improved HSC, advocating co-produced community-driven services to meet the self-defined needs of those who access and provide care
การพัฒนารูปแบบการบริหารโรงเรียนมัธยมศึกษาตามยุทธศาสตร์การพัฒนา เขตเศรษฐกิจพิเศษ ภาคตะวันออก โรงเรียนแสนสุข สังกัดสำนักงานเขตพื้นที่การศึกษามัธยมศึกษา 18
Creators: name: อาจินต์ จรูญผล
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: รูปแบบการบริหารโรงเรียนมัธยมศึกษาตามยุทธศาสตร์ EEC
โรงเรียนแสนสุข

description: Academic Journal of Thailand National Sports University, 14, 3, 267 - 280
ความสัมพันธ์ระหว่างแนวความคิดส่วนประสมทางการตลาดกับการตัดสินใจเลือกใช้บริการธุรกิจสนามแบดมินตันให้เช่า
Creators: name: ชาลิณี บำรุงแสง
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: สนามแบดมินตันให้เช่า
ปัจจัยทางการตลาด
การตัดสินใจเลือกใช้บริการ

description: Academic Journal of Thailand National Sports University, 14, 3, 281 - 290
Regulation of Mitogen-Activated Protein Kinases (MAPK) and Matrix Metalloproteinases (MMP) by Reactive Oxygen Species (ROS)
Creators: name: Shwartz, Sophia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Osteoarthritis (OA) is a chronic, disabling disease involving articular joints and is characterized by cartilage destruction. Pathological changes associated with osteoarthritis have been attributed to the activation of MAP kinase (MAPK) pathways by reactive oxygen species (ROS) in response to catabolic stimuli. Additionally, cartilage cells, also known as chondrocytes, produce nitric oxide (NO), a ROS. NO has been shown to readily interact with superoxide to form peroxynitrite, which in turn, is thought to mediate cartilage damage. Additionally, NO is thought to promote signals that increase matrix metalloproteinase (MMP) production, which is implicated in the breakdown of the extracellular matrix of cartilage. The purpose of this study was to observe how ROS regulate cellular mechanisms of inflammation and cartilage degradation in osteoarthritis. Chondrocytes isolated from articular cartilage were treated with endotoxin-free recombinant human fibronectin fragment (Fnf) (42 kD), recombinant human interleukin-1 (IL-1), DMNQ, or menadione. Fnf and IL-1 elicited increased levels of NO in the media while DMNQ and menadione did not. DMNQ and menadione elicited increased hydrogen peroxide (H2O2) levels in media but Fnf and IL-1 did not. Pre-treatment with the antioxidant MnTBAP reduced Fnf and IL-1-associated NO production and decreased MMP-13 production. These results suggest that NO and/or peroxynitrite may play a role in contributing to the production of degradative factors such as MMP-13. Chondrocytes were also treated with H2O2 in a dose curve 0.5 to 50 μM or Fnf, a physiological source of H2O2. Phosphorylation of MAPKs (JNK, ERK, p38) was measured in cell lysates using phospho-antibodies and oxidation was measured by probing BIAM pulled-down proteins with antibodies to MAPKs. Low levels of ROS were required for JNK activation and both low and high levels activated p38. ERK was less sensitive to oxidation than JNK but was more sensitive than p38. This suggests that differential activation of MAPKs by ROS levels represents an additional layer of regulation that distinguishes stress and non-stress signaling.
The impact of the impostor phenomenon on mental health outcomes of undergraduate students
Creators: name: Archer, Jennifer Elizabeth
Publisher: name: The University of Texas at Austin
Year: 2019
Subjects: Impostor phenomenon
Mental health

description: This paper provides an overview of the impostor phenomenon as it pertains to the mental health outcomes of college undergraduate students. This overview is framed within a larger concern for factors negatively impacting college retention. This paper reviews the origin and descriptions of the impostor phenomenon, differences based on demographic variables as well as the impostor phenomenon’s connection to career planning, mental health such as anxiety and depression, and maladaptive perfectionism. Suggestions for interventions based on the benefits of cognitive behavioral therapy in treating perfectionism as well as discussions of the potential value of self-compassion skill-building will be presented. Recommendations for future research include special attention to how impostorism is conceptualized within ethnic/racial minority communities and the value of training career counselors to recognize signs of impostorism.
การจัดการเรียนการสอนพลศึกษาออนไลน์ภายใต้ภาวะวิกฤติ COVID-19
Creators: name: วิษณุ  อรุณเมฆ
Publisher: name: Thailand National Sports University
Year: 2022
Subjects: การสอนออนไลน์
การเรียนการสอนพลศึกษาออนไลน์

description: Academic Journal of Thailand National Sports University, 14, 3, 291 - 300
Statics and dynamics of quasi one-dimensional Bose-Einstein condensate in harmonic and dimple trap
Creators: name: Akram, Javed
name: Pelster, Axel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We investigate a quasi one-dimensional $^{87}\text{Rb}$ Bose-Einstein condensate in a harmonic trap with an additional dimple trap (dT) in the center. Within a zero-temperature Gross-Pitaevskii mean-field description we provide a one-dimensional physical intuitive model, which we solve by both a time-independent variational approach and numerical calculations. With this we obtain at first equilibrium results for the emerging condensate wave function which reveal that a dimple trap potential induces a bump or a dip in case of a red- or a blue-detuned Gaussian laser beam, respectively. Afterwards, we investigate how this dT induced bump/dip-imprint upon the condensate wave function evolves for two quench scenarios. At first we consider the generic case that the harmonic confinement is released. During the resulting time-of-flight expansion it turns out that the dT induced bump in the condensate wave function remains present, whereas the dip starts decaying after a characteristic time scale which decreases with increasing blue-detuned dT depth. Secondly, once the red- or blue-detuned dT is switched off, we find that bright shock-waves or gray/dark bi-soliton trains emerge which oscillate within the harmonic confinement with a characteristic frequency.