cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development
Creators: name: Schmitt, Christopher E.
name: Kim, Se-Hee
name: Holland, Melinda B.
name: Woolls, Melissa J.
name: Jin, Suk-Won
name: Kim, Jun-Dae
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Segregation of two axial vessels, the dorsal aorta and caudal vein, is one of the earliest patterning events occur during development of vasculature. Despite the importance of this process and recent advances in our understanding on vascular patterning during development, molecular mechanisms that coordinate the segregation of axial vessels remain largely elusive. In this report, we find that Vascular Endothelial Growth Factor-A (Vegf-A) signaling regulates the segregation of dorsal aorta and axial vein during development. Inhibition of Vegf-A pathway components including ligand Vegf-A and its cognate receptor Kdrl, caused failure in segregation of axial vessels in zebrafish embryos. Similarly, chemical inhibition of Mitogen-activated protein kinase kinase (Map2k1)/Extracellular-signal-regulated kinases (Erk) and Phosphatidylinositol 3-kinases (PI3K), which are downstream effectors of Vegf-A signaling pathway, led to the fusion of two axial vessels. Moreover, we find that restoring Erk activity by over-expression of constitutively active MEK in embryos with a reduced level of Vegf-A signaling can rescue the defects in axial vessel segregation. Taken together, our data show that segregation of axial vessels requires the function of Vegf-A signaling, and Erk may function as the major downstream effector in this process.
การแสดงบทบาทข้ามเพศ: แนวคิดนอกกรอบเพศภาวะและปัจจัยหลักที่ส่งผลต่อการข้ามเพศ
Creators: name: ญาณวุฒิ ดวงดารา
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: การแสดงบทบาทข้ามเพศ
นาฏกรรม
เพศภาวะ

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 97-122
Estimating the effect of a rifampicin resistant tuberculosis diagnosis by the Xpert MTB/RIF assay on two-year mortality
Creators: name: Van Rie, Annelies
name: De Vos, Elise
name: Stevens, Wendy
name: Scott, Lesley
name: da Silva, Pedro
name: Hayes, Cindy
name: de Lima, Yara Voss
name: Westreich, Daniel
Publisher: name: Public Library of Science
Year: 2023

description: Studies assessing patient-centred outcomes of novel rifampicin resistant tuberculosis (RR-TB) diagnostics are rare and mostly apply conventional methods which may not adequately address biases. Even though the Xpert MTB/RIF molecular assay was endorsed a decade ago for simultaneous diagnosis of tuberculosis and RR-TB, the impact of the assay on mortality among people with RR-TB has not yet been assessed. We analysed data of an observational prospective cohort study (EXIT-RIF) performed in South Africa. We applied a causal inference approach using inverse odds of sampling weights to rectify survivor bias and selection bias caused by differing screening guidelines. We also adjusted for confounding using a marginal structural model with inverse probability of treatment weights. We estimated the total effect of an RR-TB diagnosis made by the Xpert assay versus the pre-Xpert diagnostic algorithm (entailing a targeted Line Probe Assay (LPA) among TB-confirmed patients) on two-year mortality and we assessed mediation by RR-treatment initiation. Of the 749 patients diagnosed with RR-TB [247 (33%) by the pre-Xpert diagnostic algorithm and 502 (67%) by the Xpert assay], 42.7% died. Of these, 364 (48.6%) patients died in the pre-Xpert group and 200 (39.8%) in the Xpert group. People diagnosed with RR-TB by the Xpert assay had a higher odds of RR-TB treatment initiation compared to those diagnosed by the targeted LPA-based diagnostic process (OR 2.79; 95%CI 2.19–3.56). Receiving an RR-TB diagnosis by Xpert resulted in a 28% reduction in the odds of mortality within 2 years after presentation to the clinic (ORCI 0.72; 95%CI 0.53–0.99). Causal mediation analysis suggests that the higher rate of RR-TB treatment initiation in people diagnosed by the Xpert assay explains the effect of Xpert on 2-year mortality [natural indirect effect odds ratio 0.90 (95%CI 0.85–0.96). By using causal inference methods in combination with high quality observational data, we could demonstrate that the introduction of the Xpert assay caused a 28% reduction in 2-year odds of mortality of RR-TB. This finding highlights the need for advocacy for a worldwide roll-out of rapid molecular tests. Because the effect is mainly caused by increased RR-TB treatment initiation, health care systems should also ensure timely initiation of effective treatment upon an RR-TB diagnosis.
Protagonismo violento y modos de representación en La ciudad y los perros (1963)
Creators: name: Aguila, Jesús Miguel Delgado Del
Publisher: name: Zenodo
Year: 2017
Subjects: La ciudad y los perros
Mario Vargas Llosa
Literatura peruana
boom latinoamericano
violencia
análisis textual

description: El enfoque central de esta investigación es la configuración teórica de la violencia en La ciudad y los perros y la interacción representada entre los personajes principales (para aludir al Jaguar, el Poeta y el Esclavo; para ellos ha usado convencionalmente el término «tríada protagónica»; a la vez, asume que estos personajes podrían ser entidades dispuestas a los posteriores análisis). Desarrolla la metateoría de los triángulos jerárquicos — la cual será convencionalmente graficada de forma piramidal, para que con ello se represente la idea de superioridad e inferioridad con respecto a algún rango asignado a los valores o los personajes —, estos facilitarán la demostración del carácter evolutivo de la violencia en la tríada protagónica (por lo que el Esclavo sería un primer portador mínimo de la violencia; luego, el Poeta, con un poco más de agresión; y, finalmente, el Jaguar, quien estaría configurado como violento, dandi, agresor y manipulador). La forma de demostrar esta metateoría compuesta se basa en una mecánica repetitiva y cíclica, en su mayoría, de apropiación o rechazo hacia un determinado carácter, como también referente al ascenso y el descenso por los cuales atraviesa la valoración del mismo.
การออกแบบอัตลักษณ์ผลิตภัณฑ์ของที่ระลึกในชุมชนแขวงหิรัญรูจี เขตธนบุรี กรุงเทพมหานคร
Creators: name: ประยงค์ อ่อนตา
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: อัตลักษณ์
ผลิตภัณฑ์ของที่ระลึก
การออกแบบ

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 123-144
Estimating the effects of COVID-19 on essential health services utilization in Uganda and Bangladesh using data from routine health information systems
Creators: name: Rakib, Nibras Ar
name: Angeles, Gustavo
name: Kibria, Mohammad Golam
name: Ahsan, Karar Zunaid
name: Weiss, William
name: Mpiima, Jamiru
name: Silverstein, Hannah
name: Escudero, Gabriela
name: Singh, Kavita
name: Simmons, Elizabeth
Publisher: name: Frontiers Media SA
Year: 2023

description: Background Since March 2020, the coronavirus disease 2019 (COVID-19) pandemic has been a major shock to health systems across the world. We examined national usage patterns for selected basic, essential health services, before and during the COVID-19 pandemic in Uganda and Bangladesh, to determine whether COVID-19 affected reporting of service utilization and the use of health services in each country. Methods We used routine health information system data since January 2017 to analyze reporting and service utilization patterns for a variety of health services. Using time series models to replicate pre-COVID-19 trajectories over time we estimated what levels would have been observed if COVID-19 had not occurred during the pandemic months, starting in March 2020. The difference between the observed and predicted levels is the COVID-19 effect on health services. Results The time trend models for Uganda and Bangladesh closely replicated the levels and trajectories of service utilization during the 38 months prior to the COVID-19 pandemic. Our results indicate that COVID-19 had severe effects across all services, particularly during the first months of the pandemic, but COVID-19 impacts on health services and subsequent recovery varied by service type. In general, recovery to expected levels was slow and incomplete across the most affected services. Conclusion Our analytical approach based on national information system data could be very useful as a form of surveillance for health services disruptions from any cause leading to rapid responses from health service managers and policymakers.
ENGLISH BORROWING-NEOLOGISMS IN RUSSIAN AND KYRGYZ LANGUAGES
Creators: name: Berdibekova, A.N.
name: Turgunbaeva Zh.Zh.
name: Toktomamatova, G.T.
name: Zaripbekova, A.Z.
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2023
Subjects: VOCABULARY
BORROWED VOCABULARY
ANGLICISMS
NEOLOGISMS
ASSIMILATION

description: The languages of the globe influence various social situations, phenomena occurring in society. As in all languages of the world, the vocabulary of the Russian and Kyrgyz languages is also continuously updated with new words. Every day, changes occur in his vocabulary: new words appear, some of them become obsolete, some even go out of use, others undergo semantic changes in meanings, acquire new roles. In this article, the authors consider the problem of using borrowed vocabulary, in particular, neologisms that originated from the English language. The classification of the reasons for the emergence of anglicisms is given, the ways of their assimilation with the Russian and Kyrgyz languages are given.
Multi-symplectic discretisation of wave map equations
Creators: name: Cohen, David
name: Verdier, Olivier
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 35Q51, 35Q53, 37K05, 37K10, 37M15, 65M06, 65M99, 65P10

description: We present a new multi-symplectic formulation of constrained Hamiltonian partial differential equations, and we study the associated local conservation laws. A multi-symplectic discretisation based on this new formulation is exemplified by means of the Euler box scheme. When applied to the wave map equation, this numerical scheme is explicit, preserves the constraint and can be seen as a generalisation of the Shake algorithm for constrained mechanical systems. Furthermore, numerical experiments show excellent conservation properties of the numerical solutions.
Purification, cellular levels, and functional domains of lipase maturation factor 1
Creators: name: Babilonia-Rosa, Melissa A.
name: Neher, Saskia B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Over a third of the US adult population has hypertriglyceridemia, resulting in an increased risk of atherosclerosis, pancreatitis, and metabolic syndrome. Lipoprotein lipase (LPL)1, a dimeric enzyme, is the main lipase responsible for TG clearance from the blood after food intake. LPL requires an endoplasmic reticulum (ER)-resident, transmembrane protein known as lipase maturation factor 1 (LMF1) for secretion and enzymatic activity. LMF1 is believed to act as a client specific chaperone for dimeric lipases, but the precise mechanism by which LMF1 functions is not understood. Here, we examine which domains of LMF1 contribute to dimeric lipase maturation by assessing the function of truncation variants. N-terminal truncations of LMF1 show that all the domains are necessary for LPL maturation. Fluorescence microscopy and protease protection assays confirmed that these variants were properly oriented in the ER. We measured cellular levels of LMF1 and found that it is expressed at low levels and each molecule of LMF1 promotes the maturation of 50 or more molecules of LPL. Thus we provide evidence for the critical role of the N-terminus of LMF1 for the maturation of LPL and relevant ratio of chaperone to substrate.
Hydrodroma tonapii Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Hydrodromidae
Hydrodroma
Hydrodroma tonapii

description: Hydrodroma tonapii Cook, 1967
Records from the study area: Kerala—Cook (1967); Prasad (1974); Pešić & Smit (2007a).
Habitat: Mountain streams.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 6, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
ความเข้าใจคำกริยาในภาษาไทยของเด็กพิเศษกลุ่มดาวน์ซินโดรม
Creators: name: ศุภาวีร์ บุญเสวก
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: ความเข้าใจ
คำกริยา
เด็กพิเศษ
ดาวน์ซินโดรม

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 145-160
The asymmetry and the diurnal variation in axionic dark matter searches
Creators: name: Semertzidis, Y.
name: Vergados, J. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the present work we study possible time dependent effects in Axion Dark Matter searches employing resonant cavities. We find that the width of the resonance, which depends on the axion mean square velocity in the local frame, will show an annual variation due to the motion of the Earth around the sun (modulation). Furthermore, if the experiments become directional, employing suitable resonant cavities, one expects large asymmetries in the observed widths relative to the sun's direction of motion. Due to the rotation of the Earth around its axis, these asymmetries will manifest themselves as a diurnal variation in the observed width.
description: 14 pages, 10 figures. References added, Published in Nuc. Phys. B 897 (2015) 821
Estimating the proportion of clinically suspected cholera cases that are true Vibrio cholerae infections: A systematic review and meta-analysis
Creators: name: Zou K.
name: Wiens K.E.
name: Lessler J.
name: Xu H.
name: Mwaba J.
name: Lee E.C.
name: Malembaka E.B.
name: Qadri F.
name: Azman A.S.
name: Demby M.N.
name: Bwire G.
Publisher: name: Public Library of Science
Year: 2023

description: Background Cholera: surveillance relies on clinical diagnosis of acute watery : diarrhea. Suspected cholera case definitions have high sensitivity but low specificity, challenging our ability to characterize cholera burden and epidemiology. Our objective was to estimate the proportion of clinically suspected cholera that are true Vibrio cholerae infections and identify factors that explain variation in positivity. Methods and findings We conducted a systematic review of studies that tested ≥10 suspected cholera cases for V. cholerae O1/O139 using culture, PCR, and/or a rapid diagnostic test. We searched PubMed, Embase, Scopus, and Google Scholar for studies that sampled at least one suspected case between January 1, 2000 and April 19, 2023, to reflect contemporary patterns in V. cholerae positivity. We estimated diagnostic test sensitivity and specificity using a latent class meta-analysis. We estimated V. cholerae positivity using a random-effects meta-analysis, adjusting for test performance. We included 119 studies from 30 countries. V. cholerae positivity was lower in studies with representative sampling and in studies that set minimum ages in suspected case definitions. After adjusting for test performance, on average, 52% (95% credible interval (CrI): 24%, 80%) of suspected cases represented true V. cholerae infections. After adjusting for test performance and study methodology, the odds of a suspected case having a true infection were 5.71 (odds ratio 95% CrI: 1.53, 15.43) times higher when surveillance was initiated in response to an outbreak than in non-outbreak settings. Variation across studies was high, and a limitation of our approach was that we were unable to explain all the heterogeneity with study-level attributes, including diagnostic test used, setting, and case definitions. Conclusions In this study, we found that burden estimates based on suspected cases alone may overestimate the incidence of medically attended cholera by 2-fold. However, accounting for cases missed by traditional clinical surveillance is key to unbiased cholera : burden estimates. Given the substantial variability in positivity between settings, extrapolations from suspected to confirmed cases, which is necessary to estimate cholera incidence rates without exhaustive testing, should be based on local data.
การบริหารจัดการเพื่อคุณภาพชีวิตของผู้สูงอายุในบ้านพักผู้สูงอายุ คามิลเลียน โซเชียล เซนเตอร์ สามพราน
Creators: name: ธนัฎฐา เลิศเสรีพัฒนกุล
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: การบริหารจัดการ
คุณภาพชีวิต
บ้านพักผู้สูงอายุ
ผู้สูงอายุ
ความสุข

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 161-184
DEC1 negatively regulates AMPK activity via LKB1
Creators: name: Muragaki, Yasuteru
name: Zhang, Yanping
name: Sato, Fuyuki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Basic helix-loop-helix (bHLH) transcription factor DEC1 (bHLHE40/Stra13/Sharp2) is one of the clock genes that show a circadian rhythm in various tissues. AMP-activated protein kinase (AMPK) activity plays important roles in the metabolic process and in cell death induced by glucose depletion. Recent reports have shown that AMPK activity exhibited a circadian rhythm. However, little is known regarding the regulatory mechanisms involved in the circadian rhythm of AMPK activity. The aim of this study is to investigate whether there is a direct correlation between DEC1 expression and AMPK activity. DEC1 protein and AMPK activity showed a circadian rhythm in the mouse liver with different peak levels. Knocking down DEC1 expression increased AMPK activity, whereas overexpression of DEC1 decreased it. Overexpressing the DEC1 basic mutants had little effect on the AMPK activity. DEC1 bound to the E-box of the LKB1 promoter, decreased LKB1 activity and total protein levels. There was an inverse relationship between DEC1 expression and AMPK activity. Our results suggest that DEC1 negatively regulates AMPK activity via LKB1.
ชงโคบาน: บทประพันธ์เพลงที่มีแนวคิดจากดอกไม้ประจำมหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Creators: name: จีระพันธ์ อ่อนเถื่อน
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: ชงโคบาน
บทประพันธ์เพลง
ดอกไม้ประจำมหาวิทยาลัย
เพลงสมัยนิยม

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 185-210
El Proyecto de Educación Digital (PED) para la transformación del ecosistema educativo. Design Thinking
Creators: name: Valverde-Berrocoso, Jesús
Publisher: name: Zenodo
Year: 2021
Subjects: Educational Technology
Digital Education
Teacher education
Design Thinking
Educational Innovation

description: Este working paper describe el proceso para el diseño y elaboración de un Proyecto de Educación Digital (PED) siguiendo los principios del Design Thinking. Se desarrolla en 4 sesiones de duración variable. La primera sesión es la Fase de Descubrimiento que se implemena en tres pasos: (1) Cartografías del ecosistema educativo; (2) Exposición oral de las cartografías; (3) Definición de los desafíos. La segunda sesión corresponde con la Fase de Interpretación y se desarrolla en los siguientes pasos: (1) Debate sobre prácticas docentes con tecnologías vinculadas a los desafíos; (2) Identificación de prácticas docentes; (3) Saber hacer + Deseos y expectativas. La sesión 3 se ocupa de la Fase de Ideación, e incluye tres pasos: (1) Lluvia de ideas (brainstorming); (2) Elaboración de mapas conceptuales; (3) Priorización de las ideas expresadas en los mapas conceptuales. La última sesión se corresponde con la Fase de Experimentación e implica los siguientes pasos: (1) un prototipo para el PED; (2) retroalimentación sobre el PED; (3) comunicar el PED a toda la comunidad educativa.
Some applications of almost analytic extensions to operator bounds in trace ideals
Creators: name: Gesztesy, Fritz
name: Nichols, Roger
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: Mathematical Physics (math-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: Primary: 47A30, 47A53, 47A60, 47B10, Secondary: 47B25, 30D99, 35Q40

description: Using the Davies-Helffer-Sjöstrand functional calculus based on almost analytic extensions, we address the following problem: Given self-adjoint operators $S_j$, $j=1,2$, in $\mathcal{H}$, and functions $f$ in an appropriate class, for instance, $f \in C_0^{\infty}(\mathbb{R})$, how to control the norm $\|f(S_2) - f(S_1)\|_{\mathcal{B}(\mathcal{H})}$ in terms of the norm of the difference of resolvents, $\|(S_2 - z_0 I_{\mathcal{H}})^{-1} - (S_2 - z_0 I_{\mathcal{H}})^{-1}\|_{\mathcal{B}(\mathcal{H})}$, for some $z_0 \in \mathbb{C}\backslash\mathbb{R}$. We are particularly interested in the case where $\mathcal{B}(\mathcal{H})$ is replaced by a trace ideal, $\mathcal{B}_p(\mathcal{H})$, $p \in [1,\infty)$.
description: 20 pages, references and Remark 3.3 got updated
Evolution of a functionally intact but antigenically distinct DENV fusion loop
Creators: name: Thiono D.
name: Zhu D.
name: DeSilva A.M.
name: White L.J.
name: Baric R.S.
name: Dalben Y.R.
name: Meganck R.M.
name: Snoderly-Foster L.J.
name: Tse L.V.
name: Dong S.
Publisher: name: eLife
Year: 2023

description: A hallmark of dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. Antibody-dependent enhancement is linked to antibodies targeting the fusion loop (FL) motif of the envelope protein, which is completely conserved in mosquito-borne flaviviruses and required for viral entry and fusion. In the current study, we utilized saturation mutagenesis and directed evolution to engineer a functional variant with a mutated FL (D2-FL), which is not neutralized by FL-targeting monoclonal antibodies. The FL mutations were combined with our previously evolved prM cleavage site to create a mature version of D2-FL (D2-FLM), which evades both prM- and FL-Abs but retains sensitivity to other type-specific and quaternary cross-reactive (CR) Abs. CR serum from heterotypic (DENV4)-infected non-human primates (NHP) showed lower neutralization titers against D2-FL and D2-FLM than isogenic wildtype DENV2 while similar neutralization titers were observed in serum from homotypic (DENV2)-infected NHP. We propose D2-FL and D2-FLM as valuable tools to delineate CR Ab subtypes in serum as well as an exciting platform for safer live-attenuated DENV vaccines suitable for naïve individuals and children.
Generalized Labeled Multi-Bernoulli Approximation of Multi-Object Densities
Creators: name: Papi, Francesco
name: Vo, Ba-Ngu
name: Vo, Ba-Tuong
name: Fantacci, Claudio
name: Beard, Michael
Publisher: name: arXiv
Year: 2014
Subjects: subject: Other Statistics (stat.OT)
subject: FOS: Computer and information sciences

description: In multi-object inference, the multi-object probability density captures the uncertainty in the number and the states of the objects as well as the statistical dependence between the objects. Exact computation of the multi-object density is generally intractable and tractable implementations usually require statistical independence assumptions between objects. In this paper we propose a tractable multi-object density approximation that can capture statistical dependence between objects. In particular, we derive a tractable Generalized Labeled Multi-Bernoulli (GLMB) density that matches the cardinality distribution and the first moment of the labeled multi-object distribution of interest. It is also shown that the proposed approximation minimizes the Kullback-Leibler divergence over a special tractable class of GLMB densities. Based on the proposed GLMB approximation we further demonstrate a tractable multi-object tracking algorithm for generic measurement models. Simulation results for a multi-object Track-Before-Detect example using radar measurements in low signal-to-noise ratio (SNR) scenarios verify the applicability of the proposed approach.
Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity
Creators: name: Johnson, Gary L.
name: Ahmad, Syed
name: Scott, John E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The kinase MEKK2 (MAP3K2) may play an important role in tumor growth and metastasis for several cancer types. Thus, targeting MEKK2 may represent a novel strategy for developing more effective therapies for cancer. In order to identify small molecules with MEKK2 inhibitory activity, we screened a collection of known kinase inhibitors using a high throughput MEKK2 intrinsic ATPase enzyme assay and confirmed activity of the most potent hits with this primary assay. We also confirmed activities of these known kinase inhibitors with an MEKK2 transphosphorylation slot blot assay using MKK6 as a substrate. We observed a good correlation in potencies between the two orthogonal MEKK2 kinase activity assay formats for this set of inhibitors. We report that ponatinib, AT9283, AZD7762, JNJ-7706621, PP121 and hesperadin had potent MEKK2 enzyme inhibitory activities ranging from 4.7 – 60 nM IC50. Ponatinib is an FDA-approved drug that potently inhibited MEKK2 enzyme activity with IC50 values of 10 – 16 nM. AT9283 is currently in clinical trials and produced MEKK2 IC50 values of 4.7 – 18 nM. This set of known kinase inhibitors represents some of the most potent in vitro MEKK2 inhibitors reported to date and may be useful as research tools. Although these compounds are not selective for MEKK2, the structures of these compounds give insight into pharmacophores that potently inhibit MEKK2 and could be used as initial leads to design highly selective inhibitors of MEKK2.
Bile-salt inhibition of sodium ion-coupled D-glucose and L-alanine accumulation by brush-border-membrane vesicles from hamster jejunum
Creators: name: Beesley, R C
name: Faust, R G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1980

description: The effects of bile salts on Na+-coupled accumulation of D-glucose and L-alanine by brush-border-membrane vesicles isolated from hamster jejunum were investigated. The approximate percentage inhibition of Na+-coupled D-glucose accumulation produced by various bile salts at a concentration of 1 mM were: deoxycholate and chenodeoxycholate, 60%; glycine and taurine conjugates of deoxycholate and chenodeoxycholate, 40--50%; lithocholate, 45%; cholate and its glycine and taurine conjugates, less than 10%. Inhibition of Na+-coupled accumulation of D-glucose was rapid, reversible and not due to dissolution of the vesicles. Na+-coupled accumulation of L-alanine was also inhibited by deoxycholate. Deoxycholate but not cholate enhanced (1) the rate of Na+ influx, (2) the rate of influx of D-glucose and L-alanine in the absence of a Na+ gradient and (3) the rate of efflux of D-glucose and L-alanine from vesicles preloaded with this sugar or amino acid. Deoxycholate-stimulated efflux of D-glucose was not blocked by phlorizin, which completely prevented efflux in the absence of this bile salt. These results suggest that selected bile salts inhibit Na+-coupled accumulation of D-glucose and L-alanine by enhancing the rate of dissipation of the Na+ gradient required for substrate accumulation. In addition, bile salts may also decrease D-glucose and L-alanine accumulation by increasing the rate of efflux of these substrates across the brush-border plasma membrane.
บทสำรวจว่าด้วยบทบาทขององค์กรปกครองส่วนท้องถิ่นท่ามกลางวิกฤตโควิด-19
Creators: name: สิริณัฏฐ์ เพชรศรีชาติ
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: การกระจายอำนาจ
บทบาทขององค์กรปกครองส่วนท้องถิ่น
การจัดการโควิด-19

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 211-236
ปัญหากฎหมายการคุ้มครองผู้เสียหายกรณีเจ้าหน้าที่ตำรวจปฏิเสธไม่รับคำร้องทุกข์
Creators: name: ปวรุตม์ บัวประเสริฐยิ่ง
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: คำร้องทุกข์
ดุลพินิจ
ถ่วงดุลอำนาจ
การคุ้มครองผู้เสียหาย

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 237-262
The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysis
Creators: name: Thurman, R G
name: Yuki, T
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1980

description: Gastric intubation of female Sprague-Dawley rats with 5 g of ethanol/kg body wt. nearly doubled oxygen uptake by the isolated perfused rat liver maximally after only 2.5 h of treatment (Swift Increase in Alcohol Metabolism). Inhibition of enhanced oxygen uptake by KCN (2mM) and 4-methylpyrazole (0.8 mM) suggested the involvement of the mitochondrial respiratory chain and alcohol dehydrogenase in this phenomenon. Glycolysis was depressed after ethanol treatment. Diminished ATP generation via glycolysis accounts for a portion (23-50%) of the increased oxygen uptake, assuming that other rates of biosynthesis remain constant. Injection of adrenaline (2 mg/kg) 1 h before perfusion mimicked partially the action of ethanol on hepatic oxygen uptake. The increases produced by ethanol and adrenaline were not additive, suggesting that adrenaline is involved in the action of ethanol. Moreover, the increase in hepatic oxygen uptake produced by 2.5 h of ethanol treatment could be blocked by either alpha-(phenoxybenzamine; 40 mg/kg) or beta-(propranolol; 40 mg/kg) adrenergic blocking agents. Blood glucose increased after ethanol treatment, supporting the involvement of glycogenolytic hormones in this effect. These data indicate that at least part of the stimulated oxygen uptake after treatment with ethanol is a result of lower rates of glycolytic ATP generation resulting from hormone (e.g. adrenaline etc.) action. The ADP not phosphorylated in the cytosol enters the mitochondria, where it stimulates oxygen uptake.
มาตรการทางกฎหมายในการควบคุมสารป้องกันแสงแดดที่เป็นพิษต่อแนวปะการัง
Creators: name: ลลิดา ไชยมงคล
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: สารป้องกันแสงแดด
ครีมกันแดดที่เป็นพิษต่อปะการัง
ปะการังฟอกขาว

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 263-304
Historic Building Inventory and Evaluation for Air Force Research Laboratory/Information Directorate, Oneida, Madison, and Herkimer Counties, New York
Creators: name: Sennott, Stephen
name: O'Rourke, Daniel J.
name: Orr, Andrew
name: Gierek, Lynn
name: Konnie Wescott
Publisher: name: Argonne National Laboratory
Year: 2022
Subjects: subject: Oneida (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/4047/oneida-county
subject: Air Force Research Laboratory/Information Directorate
valueUri: https://core.tdar.org/browse/geographic-keyword/85889/air-force-research-laboratoryinformation-directorate
subject: Rome Research Site
valueUri: https://core.tdar.org/browse/geographic-keyword/84332/rome-research-site
subject: Cold War Era
valueUri: https://core.tdar.org/browse/temporal-keyword/5551/cold-war-era
subject: Historic
valueUri: https://core.tdar.org/browse/culture-keyword/25/historic
subject: Cold War
valueUri: https://core.tdar.org/browse/culture-keyword/9419/cold-war
subject: Rome Research Site, Air Force Research Laboratory, Verona Test Annex, Newport Test Annex, Stockbridge Test Annex
valueUri: https://core.tdar.org/browse/other-keyword/167470/rome-research-site-air-force-research-laboratory-verona-test-annex-newport-test-annex-stockbridge-test-annex
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Architectural Survey
valueUri: https://core.tdar.org/browse/investigation-type/2/architectural-survey
subject: Historic Background Research
valueUri: https://core.tdar.org/browse/investigation-type/18/historic-background-research

description: This report presents the results of a historic building inventory and evaluation conducted on behalf of the United States Department of the Air Force at the Air Force Research Laboratory/Information Directorate, which includes Rome Research Site located in Oneida County, New York, and three affiliated test annexes situated in Madison and Herkimer Counties, New York. The evaluation aids the Air Force Research Laboratory/Information Directorate in managing the historic properties under its jurisdiction as required by the National Historic Preservation Act of 1966, as amended. Argonne National Laboratory evaluated 36 selected facilities at these research sites for architectural significance, integrity, and historical association with United States Department of the Air Force communications research and radar testing missions. Based upon the results of the study, Argonne National Laboratory recommends that the 36 facilities are not eligible for listing on the National Register of Historic Places.
Characterization of the inhibition of fibrin assembly by fibrinogen fragment D
Creators: name: Hermans, J
name: Hantgan, R R
name: Williams, J E
name: McDonagh, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1981

description: Fragment D (Mr 100 000) prepared from a terminal plasmin digest of fibrinogen was isolated and used to study its effect on fibrin formation. Increasing amounts of fragment D added to a solution of fibrinogen and thrombin decrease the rigidity of the resultant gel (10% of control at 2 mol of fragment D/mol of fibrinogen). Half-maximal inhibition is achieved at 1 mol of fragment D/mol of fibrinogen for non-cross-linked clots and at 1/2 mol of fragment D/mol of fibrinogen for cross-linked clots. "Clottability' decreases concomitantly with the rigidity. Only small amounts of fragment D (less than 10% for non-cross-linked gels) are incorporated into the gel. Light-scattering shows an increase in the final fibre thickness at fragment D concentrations up to 2 mol of fragment D/mol of fibrinogen, from 60 molecules/cross-section for the control to 120 molecules/cross-section. Higher fragment D concentrations lead to a decrease in the final fibre thickness. The limit fibre thickness is 8 nm, with a length of 80 nm, which is equivalent to a fibrin trimer. On the basis of results of synthetic-substrate and fibrinopeptide-release assays, it is clear that thrombin inactivation is not responsible for this effect. These data suggest that fragment D may inhibit fibrin formation by blocking the bimolecular polymerization of activated fibrin monomer molecules to form protofibrils, although additional effects on subsequent assembly steps may also be involved.
Kinetic and equilibrium metal-ion-binding behaviour reflected in a metal-ion-dependent antigenic determinant in bovine prothrombin. Comparison with bovine prothrombin fragment 1
Creators: name: Madar, D A
name: Hiskey, R G
name: Hall, T J
name: Koehler, K A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1981

description: Rabbit anti-(bovine prothrombin fragment 1) antibodies were fractionated by using fragment-1 affinity chromatography in the absence of metal ions, and showed an absolute requirement for the presence of metal ions in their interactions with bovine fragment 1 or prothrombin. These antibodies were employed to evaluate both the rate constants for a protein conformation change and the equilibrium metal-ion binding to isolated bovine fragment 1 and intact prothrombin. The close similarity of the rates obtained for the conformation change in fragment 1 and those observed in prothrombin indicated that the same process is involved in both proteins and that the non-fragment-1 region of the prothrombin has essentially no effect on this process in the fragment-1 region. Equilibrium metal-ion-binding studies indicate that the details of the metal-ion-binding process in fragment 1 and prothrombin are essentially the same. We conclude that the metal-ion-binding behaviour of the fragment-1 domain of intact prothrombin is identical with that of isolated fragment 1.
รูปแบบและเนื้อหาบทพระราชนิพนธ์เรื่องรามเกียรติ์ ชุดจองถนน ในพระบาทสมเด็จพระรามาธิบดีศรีสินทรมหาวชิราวุธ พระมงกุฎเกล้าเจ้าอยู่หัว
Creators: name: นฤมล ล้อมทอง
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: รามเกียรติ์ชุดจองถนน
รูปแบบและเนื้อหาบทพระราชนิพนธ์
รามเกียรติ์ ตอน จองถนน
รูปแบบและเนื้อหา
บทพระราชนิพนธ์
พระบาทสมเด็จพระมงกุฎเกล้าเจ้าอยู่หัว

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 305-326
The effect of Na + and K + on the thermal denaturation of Na + and + K + -dependent ATPase
Creators: name: Fischer, T H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1983

description: To increase our understanding of the physical nature of the Na+ and K+ forms of the Na+ + K+-dependent ATPase, thermal-denaturation studies were conducted in different types of ionic media. Thermal-denaturation measurements were performed by measuring the regeneration of ATPase activity after slow pulse exposure to elevated temperatures. Two types of experiments were performed. First, the dependence of the thermal-denaturation rate on Na+ and K+ concentrations was examined. It was found that both cations stabilized the pump protein. Also, K+ was a more effective stabilizer of the native state than was Na+. Secondly, a set of thermodynamic parameters was obtained by measuring the temperature-dependence of the thermal-denaturation rate under three ionic conditions: 60 mM-K+, 150 mM-Na+ and no Na+ or K+. It was found that ion-mediated stabilization of the pump protein was accompanied by substantial increases in activation enthalpy and entropy, the net effect being a less-pronounced increase in activation free energy.
A small value estimate in dimension two involving translations by rational points
Creators: name: Van Nguyen, Ngoc Ai
name: Roy, Damien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: Primary 11J85, Secondary 11J81

description: We show that, if a sequence of non-zero polynomials in $\mathbb{Z}[X_1,X_2]$ take small values at translates of a fixed point $(ξ,η)$ by multiples of a fixed rational point within the group $\mathbb{C}\times\mathbb{C}^*$, then $ξ$ and $η$ are both algebraic over $\mathbb{Q}$. The precise statement involves growth conditions on the degree and norm of these polynomials as well as on their absolute values at these translates. It is essentially best possible in some range of the parameters.
description: 19 pages, minor corrections from version 1
สัจจะสมิงนครอินทร์
Creators: name: กนกวรรณพร ผดุงชาติ
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: สมิงนครอินทร์
บุคลิกลักษณะนิสัย
คำสัตย์ปฏิญาณตนของทหารอาชีพ

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 327-352
Exploring system dynamics of complex societal issues through socio-scientific models
Creators: name: Sadler, Troy D.
name: Ke, Li
name: Lesnefsky, Rebecca
name: Kirk, Eric
Publisher: name: Frontiers Media SA
Year: 2023

description: Research on socio-scientific issues (SSI) has revealed that it is critical for learners to develop a systematic understanding of the underlying issue. In this paper, we explore how modeling can facilitate students’ systems thinking in the context of SSI. Building on evidence from prior research in promoting systems thinking skills through modeling in scientific contexts, we hypothesize that a similar modeling approach could effectively foster students’ systematic understanding of complex societal issues. In particular, we investigate the affordances of socio-scientific models in promoting students’ systems thinking in the context of COVID-19. We examine learners’ experiences and reflections concerning three unique epistemic features of socio-scientific models, (1) knowledge representation, (2) knowledge justification, and (3) systems thinking. The findings of this study demonstrate that, due to the epistemic differences from traditional scientific modeling approach, engaging learners in developing socio-scientific models presents unique opportunities and challenges for SSI teaching and learning. It provides evidence that, socio-scientific models can serve as not only an effective but also an equitable tool for addressing this issue.
ศาลกีฬาฟุตบอลของฟีฟ่า
Creators: name: ปีดิเทพ อยู่ยืนยง
Publisher: name: คณะมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา
Year: 2023
Subjects: ศาลกีฬาฟุตบอล
กระบวนการระงับข้อพิพาท
ฟีฟ่า

description: วารสารมนุษยศาสตร์และสังคมศาสตร์ มหาวิทยาลัยราชภัฏบ้านสมเด็จเจ้าพระยา, 17, 2, 353-375
Effect of glucose on 7-hydroxycoumarin glucuronide production in periportal and pericentral regions of the liver lobule
Creators: name: Conway, J G
name: Thurman, R G
name: Kauffman, F C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: The effect of starvation and glucose addition on glucuronidation was assessed in sublobular regions of the lobule in perfused livers from phenobarbital-treated rats. Fibre-optic micro-light guides were placed on periportal and pericentral areas on the surface of livers to monitor the fluorescence (excitation 366 nm, emission 450 nm) of free 7-hydroxycoumarin from the tissue surface. After infusion of 7-hydroxycoumarin (80 microM) under normoxic conditions, steady-state increases in fluorescence were reached in 6-8 min in both regions. Subsequently, the formation of non-fluorescent 7-hydroxycoumarin glucuronide was inhibited completely by perfusion with N2-saturated perfusate containing 20 mM-ethanol. The difference in fluorescence between anoxic and normoxic perfusions was due to glucuronidation under these conditions. In livers from fed rats, rates of glucuronidation in periportal and pericentral regions of the liver lobule were 8 and 19 mumol/h per g, respectively. In contrast, rates of glucuronidation were 3 and 9 mumol/h per g, respectively, in periportal and pericentral regions of livers from starved rats. Infusion of glucose (20 mM) had no effect on rates of glucuronidation in livers from fed rats; however, glucose increased rates of glucuronidation rapidly (half-time, t0.5 = 1.5 min) in periportal and pericentral regions to 7 and 17 mumol/h per g, respectively in livers from starved rats. These results indicate that the rapid synthesis of the cofactor UDP-glucuronic acid derived from glucose is an important rate-determinant for glucuronidation of 7-hydroxycoumarin in both periportal and pericentral regions of livers from starved rats.
Algebraic structures generating reaction-diffusion models: the activator-substrate system
Creators: name: Palese, Marcella
Publisher: name: arXiv
Year: 2015
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 35K57, 35Q92, 92B05

description: We shall construct a class of nonlinear reaction-diffusion equations starting from an infinitesimal algebraic skeleton. Our aim is to explore the possibility of an algebraic foundation of integrability properties and of stability of equilibrium states associated with nonlinear models describing patterns formation.
description: 11 pages; misprints corrected; Int. Conf. MPDE'14: Models in Population Dynamics and Ecology (Torino 2014)
title: Lehrlinge,  Diskriminierung und Alltagsrassismus in Südtirol
Creators: name: Mitterhofer, Johanna
name: Obukhova, Kseniia
Publisher: name: Eurac Research
publisherIdentifier: https://ror.org/01xt1w755
publisherIdentifierScheme: ROR
Year: 2024

description: Diese Studie untersucht Diskriminierungserfahrungen von Lehrlingen in der Autonomen Provinz Bozen. Sie stützt sich auf qualitative und quantitative Daten, die mit Fragebogen, Interviews und Workshops mit Lehrlingen und Experten aus den Bereichen Bildung, Berufsbildung, Antidiskriminierung und Arbeitswelt im Zeitraum 2023-2024 erhoben wurden. Aus den gesammelten Antworten ergeben sich mehrere Erkenntnisse: Einerseits berichten die Befragten von wenigen expliziten Diskriminierungs- und Rassismuserfahrungen. Andererseits weisen sie aber auch darauf hin, dass Alltagsrassismus und Mikroaggressionen sowie strukturelle Diskriminierung sowohl in der Schule als auch am Arbeitsplatz präsent sind.
Electron correlation effects in transport and tunneling spectroscopy of the Si(111)-$7\times 7$ surface
Creators: name: Odobescu, A. B.
name: Maizlakh, A. A.
name: Zaitsev-Zotov, S. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Electronic properties of the Si(111)-$7\times 7$ surface are studied using four- and two-probe conductivity measurements and tunneling spectroscopy. We demonstrate that the temperature dependence of the surface conductivity corresponds to the Efros-Shklovskii law at least in $10-100$~K temperature range. The energy gap at the Fermi level observed in tunneling spectroscopy measurements at $T\geq 5$~K vanishes by thermal fluctuations at $T\approx 30$~K, without any sign of the metal-insulator transition. We show that the low-temperature energy gap observed by the tunneling spectroscopy technique is actually the consequence of the Coulomb blockade effect.
description: 5 pages, 5 figures, alternations in the text and figures