cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Incidence and clinical manifestation of iatrogenic opioid withdrawal syndrome in mechanically ventilated patients
Creators: name: Taesotikul, Suthinee
name: Dilokpattanamongkol, Pitchaya
name: Tangsujaritvijit, Viratch
name: Suthisisang, Chuthamanee
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The incidence of iatrogenic opioid withdrawal syndrome (IOWS) in mechanically ventilated adults has been questioned in settings driven by analgosedation strategies. This study aimed to describe the incidence, risk factors and clinical impact of IOWS in mechanically ventilated adults. This prospective, observational study was performed between 1 January and 31 August 2018. IOWS was identified based on the presence of at least three signs or symptoms according to the Diagnostic and Statistical Manual 5th edition (DSM-5) criteria after opioid discontinuation or rate reduction. Incidence of IOWS, patient characteristics, opioid administration, and the impact of IOWS on the duration of mechanical ventilator and length of stay in the intensive care unit (ICU) were collected. Thirteen out of 55 patients (23.6%) manifested withdrawal symptoms. Two patients in the non-withdrawal group also developed hypertensive urgency after opioid discontinuation. Patients who received rapid once-daily weaning, especially rate reduction more than 50 µg as fentanyl equivalent per hour, were associated with IOWS. However, there was no statistically significant difference in ventilator-free days and ICU-free days. These findings showed that approximately one-fourth of mechanically ventilated patients who received opioid infusion experienced IOWS. Monitoring for IOWS is recommended especially in patients who received rapid weaning rate of opioids. Future studies to develop IOWS assessment tools with the change of hemodynamic parameters should be performed. This trial was registered in ClinicalTrials.gov: identifier NCT03374722, date of registration 15 December 2018.
Continuous-time link-based kinematic wave model: formulation, solution existence, and well-posedness
Creators: name: Han, Ke
name: Piccoli, Benedetto
name: Szeto, W. Y.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35L65, 35C05, 35B30

description: We present a continuous-time link-based kinematic wave model (LKWM) for dynamic traffic networks based on the scalar conservation law model. Derivation of the LKWM involves the variational principle for the Hamilton-Jacobi equation and junction models defined via the notions of demand and supply. We show that the proposed LKWM can be formulated as a system of differential algebraic equations (DAEs), which captures shock formation and propagation, as well as queue spillback. The DAE system, as we show in this paper, is the continuous-time counterpart of the link transmission model. In addition, we present a solution existence theory for the continuous-time network model and investigate continuous dependence of the solution on the initial data, a property known as well-posedness. We test the DAE system extensively on several small and large networks and demonstrate its numerical efficiency.
description: 39 pages, 14 figures, 2 tables, Transportmetrica B: Transport Dynamics 2015
Sennhütten auf Aberliboden : (unterhalb der Zindlenalp im Wäggithal)
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871
Subjects: Almhütte
Stall
Gaden

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Asymmetric Architecture for Heralded Single Photon Sources
Creators: name: Mazzarella, Luca
name: Ticozzi, Francesco
name: Sergienko, Alexander V.
name: Vallone, Giuseppe
name: Villoresi, Paolo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Single photon source represent a fundamental building block for optical implementations of quantum information tasks ranging from basic tests of quantum physics to quantum communication and high-resolution quantum measurement. In this paper we investigate the performance of a multiplexed system based on asymmetric configuration of multiple heralded single photon sources. {To compare the effectiveness of different designs we introduce a single-photon source performance index that is based on the value of single photon probability required to achieve a guaranteed signal to noise ratio.} The performance and scalability comparison with both currently existing multiple-source architectures and faint laser configurations reveals an advantage the proposed scheme offers in realistic scenarios. This analysis also provides insights on the potential of using such architectures for integrated implementation.
description: 11 pages, 13 figures
Temperature evolution of infrared- and Raman-active phonons in graphite
Creators: name: Giura, P.
name: Bonini, N.
name: Creff, G.
name: Brubach, J. B.
name: Roy, P.
name: Lazzeri, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We perform a comparative experimental and theoretical study of the temperature dependence up to 700 K of the frequency and linewidths of the graphite E1u and E2g optical phonons (~1590 and 1580 cm-1) by infra-red (IR) and Raman spectroscopy. Despite their similar character, the temperature dependence of the two modes is quite different, being, e.g., the frequency shift of the IR-active E1u mode is almost twice as big as that of the Raman active E2g mode. Ab initio calculations of the anharmonic properties are in remarkable agreement with measurements and explain the observed behavior.
description: 5 pages, 4 figures
Strong contribution to octet baryon mass splittings
Creators: name: Shanahan, P. E.
name: Thomas, A. W.
name: Young, R. D.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the $m_d-m_u$ contribution to the mass splittings in baryonic isospin multiplets using SU(3) chiral perturbation theory and lattice QCD. Fitting isospin-averaged perturbation theory functions to PACS-CS and QCDSF-UKQCD Collaboration lattice simulations of octet baryon masses, and using the physical light quark mass ratio $m_u/m_d$ as input, allows $M_n-M_p$, $M_{Σ^-}-M_{Σ^+}$ and $M_{Ξ^-}-M_{Ξ^0}$ to be evaluated from the full SU(3) theory. The resulting values for each mass splitting are consistent with the experimental values after allowing for electromagnetic corrections. In the case of the nucleon, we find $M_n-M_p= 2.9 \pm 0.4 \textrm{MeV}$, with the dominant uncertainty arising from the error in $m_u/m_d$.
Vieh Tränke ob den Zindlenalphütten im Wäggithal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871
Subjects: Tränkeinrichtung

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey
Creators: name: Canonica, G. Walter
name: Klimek, Ludger
name: Acaster, Sarah
name: Dollner, Ralph
name: Kaulsay, Ranbir
name: Lo, Siu Hing
name: Price, David
name: Scadding, Glenis K.
name: Valovirta, Erkka
name: Zieglmayer, Petra
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: The aims of this survey were to (1) assess the burden of allergic rhinitis (AR) from the patient perspective, (2) investigate MP-AzeFlu use in real life and its impact on patients’ lives and (3) explore factors associated with treatment satisfaction. Methods: A cross-sectional, quantitative, online, questionnaire-based survey was conducted in 7 European countries (March-June 2019). Questions explored AR burden and treatment satisfaction. Satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication 9-item (TSQM-9; max score =100). Participants (aged ≥18 years) had a doctor/healthcare provider confirmed AR diagnosis and used MP-AzeFlu within the last year. Results: Pre-MP-AzeFlu treatment, participants (n = 1004) reported an average of 3.3 (SD:3.5) doctor visits/year, 8.1 (SD:11.0) days/year absenteeism and 15.8 (SD:18.9) days/year presenteeism due to AR. Only 48% of participants used MP-AzeFlu twice/day as recommended. Post-MP-AzeFlu 57% of participants reported better QoL, 47% reported fewer doctor visits and 52% discontinued polypharmacy. Absenteeism and presenteeism were reduced by 2.5 (SD 10.0) and 7.39 (SD:16.0) days/year, respectively. 70% of participants were more/much more satisfied with MP-AzeFlu versus previous AR treatment(s), and ≥70% were satisfied/extremely satisfied with its ability to prevent/treat AR, relieve symptoms and with its onset of action. Mean global, effectiveness and convenience TSQM-9 scores were 70.0 (SD:19.8), 68.3 (SD:21.6) and 72.7 (SD:20.4), respectively. Treatment satisfaction and effectiveness were significantly improved when MP-AzeFlu was taken as recommended. Conclusions: The impact of AR on patients’ lives remains high. Real-life use of MP-AzeFlu reduces that impact and is associated with a high level of effectiveness, convenience and global satisfaction.
Fluhbrig : gez. vom Aberli ob Hinter Wäggithal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871
Subjects: Massiv

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Reconciling the nonrelativistic QCD prediction and the $J/ψ\to 3γ$ data
Creators: name: Feng, Feng
name: Jia, Yu
name: Sang, Wen-Long
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: It has been a long-standing problem that the rare electromagnetic decay process $J/ψ\to 3γ$ is plagued with both large and negative radiative and relativistic corrections. To date it remains futile to make a definite prediction to confront with the branching fraction of $J/ψ\to 3γ$ recently measured by the \textsf{CLEO-c} and \textsf{BESIII} Collaborations. In this work, we investigate the joint perturbative and relativistic correction (i.e. the ${\mathcal O}(α_s v^2)$ correction, where $v$ denotes the characteristic velocity of the charm quark inside the $J/ψ$) for this decay process, which turns out to be very significant. After incorporating the contribution from this new ingredient, with the reasonable choice of the input parameters, we are able to account for the measured decay rates in a satisfactory degree.
description: 7 pages, 1 figure, version accepted for publication in PRD RC
Incidence and Clinical Manifestation of Iatrogenic Opioid Withdrawal Syndrome in Mechanically Ventilated Patients
Creators: name: Taesotikul, Suthinee
name: Dilokpattanamongkol, Pitchaya
name: Tangsujaritvijit, Viratch
name: Suthisisang, Chuthamanee
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The incidence of iatrogenic opioid withdrawal syndrome (IOWS) in mechanically ventilated adults has been questioned in settings driven by analgosedation strategies. This study aimed to describe the incidence, risk factors and clinical impact of IOWS in mechanically ventilated adults. This prospective, observational study was performed between 1st January and 31st August 2018. IOWS was identified based on the presence of at least three signs or symptoms according to the Diagnostic and Statistical Manual 5th edition (DSM-5) criteria after opioid discontinuation or rate reduction. Incidence of IOWS, patient's characteristics, opioid administration, and the impact of IOWS on the duration of mechanical ventilator and length of stay in the intensive care unit (ICU) were collected. Thirteen out of 55 patients (23.6%) manifested withdrawal symptoms. Two patients in the non-withdrawal group also developed hypertensive urgency after opioid discontinuation. Patients who received rapid once-daily weaning, especially rate reduction more than 50 µg as fentanyl equivalent per hour, were associated with IOWS. However, there was no statistically significant difference in ventilator-free days and ICU-free days. This finding showed that approximately one-fourth of mechanically ventilated patients who received opioid infusion experienced IOWS. Monitoring for IOWS are recommended especially in patients who received rapid weaning rate of opioids. Future studies to develop IOWS assessment tools with the change of hemodynamic parameters should be performed. This trial was registered in ClinicalTrials.gov; identifier NCT03374722), date of registration; December 15, 2018.
Lattice study of conformality in twelve-flavor QCD
Creators: name: Aoki, Yasumichi
name: Aoyama, Tatsumi
name: Kurachi, Masafumi
name: Maskawa, Toshihide
name: Nagai, Kei-ichi
name: Ohki, Hiroshi
name: Shibata, Akihiro
name: Yamawaki, Koichi
name: Yamazaki, Takeshi
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study infrared conformality of the twelve-flavor QCD on the lattice. Utilizing the highly improved staggered quarks (HISQ) type action which is useful to study the continuum physics, we analyze the lattice data of the mass and the decay constant of a pseudoscalar meson and the mass of a vector meson as well at several values of lattice spacing and fermion mass. Our result is consistent with the conformal hypothesis for the mass anomalous dimension $γ_m \sim 0.4-0.5$.
description: 38pages, 21figures
Personalia
Creators: name: Redaktion, Die
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Bd. 1 Nr. 10 (1948): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Zindlenalp Hütten im Wäggithal : 1540 mt
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871
Subjects: Almhütte

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Ausstellungskalender
Creators: name: Redaktion, Die
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Bd. 1 Nr. 7/8 (1948): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Effects of photon trapping on the Lyman-alpha properties of star-forming galaxies
Creators: name: Yajima, Hidenobu
name: Li, Yuexing
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recent observations show that a large number of Lyman-alpha emitters (LAEs) at high redshift z >= 3 have unusually high Lya equivalent widths (EW > 400 angstrom). However, the origin of these high EWs is an open question. Here, we investigate the impacts of photon trapping on the Lya EW and other properties by tracking the Lya radiative transfer in spherical galactic clouds. We find that the delayed escape of the Lya photons can change the Lya properties significantly. During the transition phase from optically thick to optically thin where the Lya photons can escape simultaneously, the EW can be boosted to ~ 1000 angstrom, the Lya luminosity can be increased by a factor of a few, and the line profile can be significantly broadened. The boost factor appears to depend on the galaxy properties such as mass and star formation rate and timescale, therefore future investigation combing 3D Lya RT calculations with cosmological simulations of galaxy formation and evolution is needed to fully understand the Lya properties of early star-forming galaxies.
description: 7 pages, 7 figures, accepted for publication in MNRAS
Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis
Creators: name: Alamer, Ahmad
name: Alrashed, Ahmed A.
name: Alfaifi, Mashael
name: Alosaimi, Bandar
name: AlHassar, Fatimah
name: Almutairi, Malak
name: Howaidi, Jude
name: Almutairi, Wedad
name: Mohzari, Yahya
name: Sulaiman, Tarek
name: Al-jedai, Ahmed
name: Alajami, Hamdan N.
name: Alkharji, Fatima
name: Alsaeed, Ali
name: Alali, Alaa H.
name: Baredhwan, Abdullah A.
name: Abraham, Ivo
name: Almulhim, Abdulaziz S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Favipiravir is a repurposed drug to treat coronavirus 2019 (COVID-19). Due to a lack of available real-world data, we assessed its effectiveness and safety in moderately to critically ill COVID-19 patients. This retrospective study was conducted in two public/specialty hospitals in Saudi Arabia. We included patients ≥18 years) admitted April–August 2020 with confirmed SARS-CoV-2 diagnosed by real-time polymerase chain reaction (RT-PCR) from nasopharyngeal swab. Patients received either favipiravir (1800 mg or 1600 mg twice daily loading dose, followed by 800 mg or 600 mg twice daily) or supportive-care treatment. Patients were excluded if they were outside the study period, classified as having a mild form of the disease per WHO criteria, or had an incomplete patient file. Kaplan–Meier (KM) models were used to estimate median time to discharge. Discharge ratios, progression to mechanical ventilation, and mortality outcomes were estimated across the severity spectrum using Cox proportional-hazards models. As a sensitivity analysis, we performed propensity score-matching (PSM) analysis. Overall, median time to discharge was 10 days (95%CI = 9–10) in the favipiravir arm versus 15 days (95%CI = 14–16) in the supportive-care arm. The accelerated discharge benefit was seen across the COVID-19 spectrum of severity. The adjusted discharge ratio was 1.96 (95%CI = 1.56–2.46). Progression to mechanical ventilation was slower with favipiravir (HRadj = 0.10, 95%CI = 0.04–0.29). There was no significant effect on mortality (HRadj = 1.56, 95%CI = 0.73–3.36). There was a statistically non-significant trend toward worse outcomes in the critical category (HRadj = 2.80, 95%CI = 0.99–7.89). Age was an independent risk factor for mortality in mechanically ventilated patients. PSM analyses confirmed these findings. Favipiravir was associated with clinical benefits, including accelerated discharge rate and less progression to mechanical ventilation; however, no overall mortality benefits were seen across the severity spectrum.
Oberster Gaden (Viehstall) auf Zindlenalp unter Zindlenspitz
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871
Subjects: Stall
Gaden

description: [Johann Müller-Wegmann]
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Inhalt
Creators: name: Redaktion, Die
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Vol 3 No 1 (1950): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Gipfel des Zindlenspitz im Wäggithal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871

description: Ansicht des Berggipfels Zindlenspitz mit einer kleinen Skizze des Berges "Zindlenspitz von Süd Westen" in der rechten oberen Ecke
description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Tafeln
Creators: name: Redaktion, Die
Publisher: name: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Year: 2019

description: Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege, Vol 3 No 1 (1950): Kunstchronik. Monatsschrift für Kunstwissenschaft, Museumswesen und Denkmalpflege
Alphütte auf dem Bockmattli im Wäggithal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871
Subjects: Almhütte

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Der  Bächistock und Gletscher am Glärnisch durch Fernrohr : vom Schlafzimer in der Jris (Mühlebach)
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1868
Subjects: Gletscher

description: IM.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Exotic symmetry and monodromy equivalence in Schrodinger sigma models
Creators: name: Kawaguchi, Io
name: Yoshida, Kentaroh
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider the classical integrable structure of two-dimensional non-linear sigma models with target space three-dimensional Schrodinger spacetimes. There are the two descriptions to describe the classical dynamics: 1) the left description based on SL(2,R)_L and 2) the right description based on U(1)_R. We have shown the sl(2,R)_L Yangian and q-deformed Poincare algebras associated with them. We proceed to argue an infinite-dimensional extension of the q-deformed Poincare algebra. The corresponding charges are constructed by using a non-local map from the flat conserved currents related to the Yangian. The exotic tower structure of the charges is revealed by directly computing the classical Poisson brackets. Then the monodromy matrices in both descriptions are shown to be gauge-equivalent via the relation between the spectral parameters. We also give a simple Riemann sphere interpretation of this equivalence.
description: 27 pages, 3 figures, LaTeX, Further clarifications added
Exact description of the magnetoelectric effect in the spin-1/2 XXZ-chain with Dzyaloshinskii-Moriya interaction
Creators: name: Brockmann, Michael
name: Klümper, Andreas
name: Ohanyan, Vadim
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider a simple integrable model of a spin chain exhibiting the Magnetoelectric Effect (MEE). Starting from the periodic S=1/2 XXZ-chain with Dzyaloshinskii-Moriya terms, which we consider as a local electric polarization in the spirit of the Katsura-Nagaosa-Baladsky (KNB) mechanism, we perform the mapping onto the conventional XXZ-chain with twisted boundary conditions. Using the techniques of Quantum Transfer Matrix (QTM) and Non-Linear Integral Equations (NLIE) we obtain the magnetization, electric polarization and magnetoelectric tensor as functions of magnetic and electric field for arbitrary temperatures. We investigate these dependencies as well as the thermal behavior of the above mentioned physical quantities, especially in the low-temperature regime. We found several regimes of polarization. Adjusting the magnetic field one can switch the system from one regime to another. The features of the critical properties connected with the MEE are also illustrated.
description: 11 pages; 6 figures
Simple explanation of the quantum violation of a fundamental inequality
Creators: name: Cabello, Adan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We show that the maximum quantum violation of the Klyachko-Can-Binicioglu-Shumovsky (KCBS) inequality is exactly the maximum value satisfying the following principle: The sum of probabilities of pairwise exclusive events cannot exceed 1. We call this principle "global exclusivity," since its power shows up when it is applied to global events resulting from enlarged scenarios in which the events in the inequality are considered jointly with other events. We identify scenarios in which this principle singles out quantum contextuality, and show that a recent proof excluding nonlocal boxes follows from the maximum violation imposed by this principle to the KCBS inequality.
description: REVTeX4, 6 pages, 3 figures
Der  Zindlenspitz im Wäggithal vom Ütliberg (wegen starkem Regen nicht fertig) : durch Fernrohr
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1871

description: IM.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Black-Hole Spin Dependence in the Light Curves of Tidal Disruption Events
Creators: name: Kesden, Michael
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A star orbiting a supermassive black hole can be tidally disrupted if the black hole's gravitational tidal field exceeds the star's self gravity at pericenter. Some of this stellar tidal debris can become gravitationally bound to the black hole, leading to a bright electromagnetic flare with bolometric luminosity proportional to the rate at which material falls back to pericenter. In the Newtonian limit, this flare will have a light curve that scales as t^-5/3 if the tidal debris has a flat distribution in binding energy. We investigate the time dependence of the black-hole mass accretion rate when tidal disruption occurs close enough the black hole that relativistic effects are significant. We find that for orbits with pericenters comparable to the radius of the marginally bound circular orbit, relativistic effects can double the peak accretion rate and halve the time it takes to reach this peak accretion rate. The accretion rate depends on both the magnitude of the black-hole spin and its orientation with respect to the stellar orbit; for orbits with a given pericenter radius in Boyer-Lindquist coordinates, a maximal black-hole spin anti-aligned with the orbital angular momentum leads to the largest peak accretion rate.
description: 16 pages, 15 figures, 1 table, PRD published version
Modelling surface restructuring by slow highly charged ions
Creators: name: Wachter, G.
name: Tökési, K.
name: Betz, G.
name: Lemell, C.
name: Burgdörfer, J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We theoretically investigate surface modifications on alkaline earth halides due to highly charged ion impact, focusing on recent experimental evidence for both etch pit and nano-hillock formation on CaF2 [A. El-Said et al, PRL 109, 117602 (2012)]. We discuss mechanisms for converting the projectile potential and kinetic energies into thermal energy capable of changing the surface structure. A proof-of-principle classical molecular dynamics simulation suggests the existence of two thresholds which we associate with etch pit and nano-hillock formation in qualitative agreement with experiment.
description: Accepted in proceedings of IISC-2012 (NIM B)
Burden of illness and treatment patterns among patients with peripheral T-cell lymphoma in the US healthcare setting
Creators: name: Petrilla, Allison A.
name: Shah, Anne
name: Feliciano, Joseph
name: Woolery, Joseph
name: LeBlanc, Thomas W.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Limited real-world information exists on the characteristics or treatment patterns of patients with peripheral T-cell lymphoma (PTCL). We reported demographics, treatments and direct healthcare resource utilization (HRU) in a large cohort of US patients newly diagnosed with PTCL. Patients aged ≥18 years with a PTCL diagnosis between January 2011 and December 2016 were identified from the Inovalon MORE2 Registry. Continuous medical/pharmacy enrollment 6-months prior to and ≥1-month after the first PTCL diagnosis was required. The main focus of this study was on newly diagnosed patients receiving cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) versus other chemotherapy. A total 2971 patients with PTCL and chemotherapy information were included in the study; 1706 (57%) received CHOP and 1265 (43%) other chemotherapy. A majority of patients (51.7%) were female; mean (standard deviation) age at index was 61.0 (±16.0), Charlson score was 4.1 (±2.9), and follow-up time was 24.6 (±16.7) months. During the variable follow-up period, HRU was similar for the CHOP and other chemotherapy cohorts; 58.1% and 59.3% had ≥1 all-cause hospitalizations, respectively. The proportion of patients with ≥1 PTCL-related hospitalizations was higher in the CHOP than in the other chemotherapy cohort (40.3% vs. 9.7%, respectively) and mean length of stay was longer (4.6 vs. 3.7 days per patient per month, respectively). This retrospective analysis of patients with PTCL revealed high levels of comorbidity and HRU; novel interventions that improve patient outcomes and reduce the HRU burden of PTCL are needed.
The topology of toric origami manifolds
Creators: name: Holm, Tara
name: Pires, Ana Rita
Publisher: name: arXiv
Year: 2012
Subjects: subject: Symplectic Geometry (math.SG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 53D20 (Primary) 55N91, 57R91 (Secondary)

description: A folded symplectic form on a manifold is a closed 2-form with the mildest possible degeneracy along a hypersurface. A special class of folded symplectic manifolds are the origami symplectic manifolds, studied by Cannas da Silva, Guillemin and Pires, who classified toric origami manifolds by combinatorial origami templates. In this paper, we examine the topology of toric origami manifolds that have acyclic origami template and co-orientable folding hypersurface. We prove that the cohomology is concentrated in even degrees, and that the equivariant cohomology satisfies the GKM description. Finally we show that toric origami manifolds with co-orientable folding hypersurface provide a class of examples of Masuda and Panov's torus manifolds.
description: 20 pages, 7 figures. Minor changes from previous version, typos fixed, bibliography updated
Editorial
Creators: name: Eitel, Bernhard
Publisher: name: Ruperto Carola
Year: 2019

description: Wissenschaft lebt vom Perspektivenwechsel: Wenn wir Dinge infrage stellen und sie aus einem anderen Blickwinkel betrachten, können wir plötzlich zu ganz neuen Ergebnissen und Erkenntnissen kommen. Was gestern noch übermächtig groß erschien, wirkt heute plötzlich ganz klein – oder aber auch umgekehrt. Was heute noch in Stein gemeißelt scheint, kann morgen bereits ins Wanken geraten – und scheinbar absolute Gewissheiten werden infrage gestellt. Kann es also in unserer Welt überhaupt etwas geben, das absoluten Bestand hat, oder ist tatsächlich alles relativ?
description: Ruperto Carola, Nr. 14 (2019): Absolut & Relativ
Alles relativ? Die Suche nach dem Absoluten
Creators: name: Bartelmann, Matthias
Publisher: name: Ruperto Carola
Year: 2019

description: Es sei eben alles relativ – mit diesen Worten werden Albert Einsteins Relativitätstheorien, die Spezielle und die Allgemeine, oft zusammengefasst. So griffig die Aussage klingt, so sehr behauptet sie das Gegenteil dessen, was diese Theorien tatsächlich leisten. Viel wichtiger für die Physik ist es, dass Einstein auch nach etwas suchte, was hinter allem Relativen steht, etwas, das wir nicht nur in der Physik, sondern tagtäglich beobachten können und das absoluten Bestand hat.
description: Ruperto Carola, Nr. 14 (2019): Absolut & Relativ
Review and meta-analysis of add-on tranylcypromine with antipsychotic drugs for the treatment of schizophrenia with predominant negative symptoms: a restoration of evidence
Creators: name: Ulrich, Sven
name: Messer, Thomas
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Treatment using add-on antidepressants with antipsychotic drugs in negative symptoms of schizophrenia has been reviewed recently in comprehensive meta-analyses. Tranylcypromine (TCP), an irreversible monoamine oxidase (MAO)-A/B inhibitor applied in treatment resistant depression, was not included because of strict requirements for quality of study design. To get a clear picture of available evidence for this resource in the treatment of schizophrenia, we conducted a review and meta-analysis of add-on TCP in the treatment of predominant negative symptoms of schizophrenia (negative schizophrenia). Seven controlled studies of add-on TCP in schizophrenia with predominant negative symptoms were found in a search of multiple databases. A subset of four studies of the prospective and parallel comparison of add-on TCP with antipsychotic drugs vs. antipsychotic drug monotherapy and meeting minimum quality criteria formed the primary meta-analysis. The effect size was calculated as the natural logarithm of the odds ratio (logOR) of responders and non-responders. In the primary meta-analysis, a pooled logOR = 1.092 with 95%CI 0.410–1.774 (I2 = 43.4%, moderate heterogeneity) was calculated according to a fixed-effect model. Heterogeneity was reduced for three double-blind studies of add-on TCP with trifluoperazine (TFP) vs. TFP-monotherapy and resulted a pooled logOR = 0.916 with 95%CI 0.216–1.616 (I2 negative, no heterogeneity). A significant logOR = 1.558 with 95%CI 0.340–2.776 was found for TCP/TFP compared to placebo in one study. In a meta-analysis of extrapyramidal adverse effects, studies were very heterogeneous and revealed no significant differences between treatments. The risk of exacerbation of positive symptoms with add-on TCP was found to be very low for a duration of treatment of 12–16 weeks. No cases of hypertensive crisis were reported. The main methodical limitations were insufficient description of randomization or matching of patients without randomization. The main clinical limitation is a gap of data for add-on TCP with second-generation antipsychotics. New studies are needed for add-on TCP with antipsychotic drugs in schizophrenia with predominant negative symptoms. Trials of this treatment may be possible in rare and selected cases. The therapeutic effect of add-on TCP may be explained by a strong dopaminergic activity.
Electron-phonon superconductivity and charge density wave instability in the layered titanium-based pnictide BaTi$_2$Sb$_2$O
Creators: name: Subedi, Alaska
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: I present the results of first principles calculations of the phonon dispersions and electron-phonon coupling for BaTi$_2$Sb$_2$O. The phonon dispersions show a weak lattice instability near the zone corners that leads to a charge-density wave phase. The calculations of the electron-phonon coupling reveal strong coupling, especially to the in-plane Ti modes. The total coupling is large enough to readily explain the superconductivity in this compound. As the Fermi surfaces are disconnected with different orbital character weights, this compound is likely to host a multiband superconductivity.
description: Added the phonon dispersions and electron-phonon coupling for the distorted structure
Observation of interstellar lithium in the low-metallicity Small Magellanic Cloud
Creators: name: Howk, J. Christopher
name: Lehner, Nicolas
name: Fields, Brian D.
name: Mathews, Grant J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The primordial abundances of light elements produced in the standard theory of Big Bang nucleosynthesis (BBN) depend only on the cosmic ratio of baryons to photons, a quantity inferred from observations of the microwave background. The predicted primordial 7Li abundance is four times that measured in the atmospheres of Galactic halo stars. This discrepancy could be caused by modification of surface lithium abundances during the stars' lifetimes or by physics beyond the Standard Model that affects early nucleosynthesis. The lithium abundance of low-metallicity gas provides an alternative constraint on the primordial abundance and cosmic evolution of lithium that is not susceptible to the in situ modifications that may affect stellar atmospheres. Here we report observations of interstellar 7Li in the low-metallicity gas of the Small Magellanic Cloud, a nearby galaxy with a quarter the Sun's metallicity. The present-day 7Li abundance of the Small Magellanic Cloud is nearly equal to the BBN predictions, severely constraining the amount of possible subsequent enrichment of the gas by stellar and cosmic-ray nucleosynthesis. Our measurements can be reconciled with standard BBN with an extremely fine-tuned depletion of stellar Li with metallicity. They are also consistent with non-standard BBN.
description: Published in Nature. Includes main text and Supplementary Information. Replaced with final title and abstract
Scattering theory of nonlinear thermoelectric transport
Creators: name: Sanchez, David
name: Lopez, Rosa
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate nonlinear transport properties of quantum conductors in response to both electrical and thermal driving forces. Within scattering approach, we determine the nonequilibrium screening potential of a generic mesoscopic system and find that its response is dictated by particle and entropic injectivities which describe the charge and entropy transfer during transport. We illustrate our model analyzing the voltage and thermal rectification of a resonant tunneling barrier. Importantly, we discuss interaction induced contributions to the thermopower in the presence of large temperature differences.
description: 5 pages, 3 figures; slightly shortened version to fulfill the journal's requirements
Bandkeramik und Hinkelstein im nördlichen Kaiserstuhlvorland
Creators: name: Stöckl, Horst
name: Westermann, Elisabeth
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2019

description: Archäologische Nachrichten aus Baden, Bd. 68/69 (2004): Archäologische Nachrichten aus Baden
Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: A retrospective study with propensity score matching sensitivity analysis
Creators: name: Alamer, Ahmad
name: Alrashed, Ahmed A
name: Alfaifi, Mashael
name: Alosaimi, Bandar
name: AlHassar, Fatimah
name: Almutairi, Malak M.
name: Howaidi, Jude
name: Almutairi, Wedad
name: Mohzari, Yahya
name: Sulaiman, Tarek
name: AlJedai, Ahmed
name: Alajami, Hamdan N.
name: Alkharji, Fatima
name: Alsaeed, Ali
name: Alali, Alaa H.
name: Baredhwan, Abdullah A.
name: Abraham, Ivo
name: Almulhim, Abdulaziz S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Medicine
Biotechnology
Cancer
Science Policy

description: Favipiravir is a repurposed drug to treat coronavirus 2019 (COVID-19). Due to a lack of available real-world data, we assessed its effectiveness and safety in moderately to critically ill COVID-19 patients. This retrospective study was conducted in two public/specialty hospitals in Saudi Arabia. We included patients (≥ 18 years) admitted April–August 2020 with confirmed SARS-CoV-2 diagnosed by real-time polymerase chain reaction (RT-PCR) from nasopharyngeal swab. Patients received either favipiravir (1800 mg or 1600 mg BID loading dose, followed by 800 mg or 600 mg QD) or supportive-care treatment. Patients were excluded if they were outside the study period, classified as having a mild form of the disease per WHO criteria, or had an incomplete patient file. Kaplan–Meier (KM) models were used to estimate median time to discharge. Discharge ratios, progression to mechanical ventilation, and mortality outcomes were estimated across the severity spectrum using Cox proportional-hazards models. As a sensitivity analysis, we performed propensity score-matching (PSM) analysis. Overall, median time to discharge was 10 days (95%CI =9-10) in the favipiravir arm versus 15 days (95%CI =14-16) in the supportive-care arm. The accelerated discharge benefit was seen across the COVID-19 spectrum of severity. The adjusted discharge ratio was 1.96 (95%CI =1.56–2.46). Progression to mechanical ventilation was slower with favipiravir (HRadj=0.10, 95%CI =0.04-0.29). There was no significant effect on mortality (HRadj=1.56, 95%CI =0.73-3.36). There was a statistically non-significant trend toward worse outcomes in the critical category (HRadj=2.80, 95%CI =0.99-7.89). Age was an independent risk factor for mortality in mechanically ventilated patients. PSM analyses confirmed these findings. Favipiravir was associated with clinical benefits, including accelerated discharge rate and less progression to mechanical ventilation; however, no overall mortality benefits were seen across the severity spectrum.
Magnetic Flux Change and Cancellation Associated with X-class and M-class Flares
Creators: name: Burtseva, Olga
name: Petrie, Gordon
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We perform a statistical study of permanent changes in longitudinal fields associated with solar flares by tracking magnetic features. The YAFTA feature tracking algorithm is applied to GONG++ one-minute magnetograms for 77 X-class and M-class flares to analyze the evolution and interaction of the magnetic features and to estimate the amount of canceled magnetic flux. We find that significantly more magnetic flux decreases than increases occurred during the flares, consistent with a model of collapsing loop structure for flares. Correlations between both total (unsigned) and net (signed) flux changes and the GOES peak X-ray flux are dominated by X-class flares at limb locations. The flux changes were accompanied in most cases by significant cancellation, most of which occurred during the flares. We find that the field strength and complexity near the polarity inversion line are approximately equally important in the flux cancellation processes that accompany the flares. We do not find a correlation between the flux cancellation events and the stepwise changes in the magnetic flux in the region.
description: Published in Solar Physics
Early discovery of top partners and test of the Higgs nature
Creators: name: Vignaroli, Natascia
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Top partners from a new strong sector can be discovered soon, at the 8 TeV LHC, by analyzing their single production, which exhibits a large enhancement in the cross section compared to the analogous productions of bottom partners and exotic quarks. We analyze the subsequent decay of the top partners into a 125 GeV Higgs. This channel proves to be very promising for both the discovery of top partners and a test of the Higgs sector. For a reference value $λ_{\tilde{T}}=3$ of the Higgs coupling to the top partner, we could have a discovery (observation) at the 8 TeV LHC, with 30 fb$^{-1}$, for top partner masses up to 760 (890) GeV. If the LHC and Tevatron excesses near 125 GeV are really due to a composite Higgs, naturalness arguments demand top partners below $\sim 1$ TeV. Our results highlight thus that the 8 TeV LHC already has a large sensitivity on probing the composite Higgs hypothesis. The LHC reach is even wider at $\sqrt{s}=14$ TeV. With $λ_{\tilde{T}}=3$ the LHC with 100 fb$^{-1}$ can observe (at 5$σ$) a Higgs from a top partner decay for masses of this latter up to $\simeq 1450$ GeV. In the case the top partner was as light as $\simeq 500$ GeV, the 14 TeV LHC would be sensitive to the measure of the $λ_{\tilde{T}}$ coupling in basically the full range $λ_{\tilde{T}}>1$ predicted by the theory.
description: 9 pp. Minor changes. Version to appear in PRD. arXiv admin note: substantial text overlap with arXiv:1204.0468
DCPP: A Drug Clinical Phase Predictor Model
Creators: name: Zinkin, Emma
name: Gribbon, Philip
name: Zaliani, Andrea
name: Gadiya, Yojana
Publisher: name: Zenodo
Year: 2023
Subjects: machine learning
clincal phase
ChEMBL
SwissADME
target classification

description: Recent advances in machine learning (ML) methodologies have enabled predictions of the potential of compounds to achieve clinical approval, based on their pre-clinical characteristics such as target affinities and chemical fingerprints. Such ML models would allow for effective prioritization of lead molecules to reduce the number of unsuccessful clinical studies. One drawback of current ML models is that they are built around target-specific features rather than polypharmacological effects. In this context, we have assembled a virtual cohort of publicly available compounds from ChEMBL (v.33) and SwissADME, and compiled their bioactivity profile (binding or functional) against target classes, physicochemical, cellular toxicity, and solubility properties, resulting in a multimodular polypharmacological dataset.  
We adopted a two-step approach. Firstly, we assessed the predictive capabilities of various ML models in determining the maximum clinical stage (approved, clinical, or preclinical) that a lead compound eventually attained. These ML models were trained using classical and ensemble-based methods (namely stacking and blending) to identify the best model from the collection. Secondly, we pinpointed the critical features contributing to the model's predictive accuracy, thus assisting future drug discovery on these key features,
With 1,300 compounds for a two-stage (i.e., approved and non-approved) classification model, we observed that the Light Gradient Boosting Machine performed the best, achieving an accuracy of 89.9% and a Cohen kappa score of 79.8%. For a smaller subset of 900 compounds, we built a three-stage classifier (i.e., pre-clinical, clinical, and approved). In this case, the Random Forest Classifier excelled, achieving an accuracy of 77.3% and a Cohen kappa score of 65.9%. Notably, both these models have identified specific physicochemical properties like SLogP and polar surface area (TPSA) and target classes like phosphodiesterase enzyme (PDE),  as significant features for predicting a drug candidate's likelihood of success in clinical trials. 
Our approach demonstrates that bioactivity data, especially target-related results which are usually considered very premature in their range of application, might provide valuable insights into a lead compound's subsequent clinical success, in a similar manner by which biomarkers can assist in the prediction of a disease outcome. Additionally, this work lays the foundation for training large language models and deep learning models to better predict the underlying clinical potential of compounds.