cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Treatment and management of primary antibody deficiency: German interdisciplinary evidence‐based consensus guideline
Creators: name: Hanitsch, Leif
name: Baumann, Ulrich
name: Boztug, Kaan
name: Burkhard‐Meier, Ulrike
name: Fasshauer, Maria
name: Habermehl, Pirmin
name: Hauck, Fabian
name: Klock, Gerd
name: Liese, Johannes
name: Meyer, Oliver
name: Müller, Rainer
name: Pachlopnik‐Schmid, Jana
name: Pfeiffer‐Kascha, Dorothea
name: Warnatz, Klaus
name: Wehr, Claudia
name: Wittke, Kirsten
name: Niehues, Tim
name: Bernuth, Horst Von
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: autoimmunity
subject: CVID
subject: hypogammaglobulinemia
subject: immunoglobulins
subject: primary antibody deficiency
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. Recommendations were based on results of a systematic literature search, data extraction, and evaluation of methodology and study quality in combination with the clinical expertise of the respective representatives. Consensus-based recommendations were determined via nominal group technique. PADs are the largest clinically relevant group of primary immunodeficiencies. Most patients with PADs present with increased susceptibility to infections, however immune dysregulation, autoimmunity, and cancer affect a significant number of patients and may precede infections. This guideline therefore covers interdisciplinary clinical and therapeutic aspects of infectious (e.g., antibiotic prophylaxis, management of bronchiectasis) and non-infectious manifestations (e.g., management of granulomatous disease, immune cytopenia). PADs are grouped into disease entities with definitive, probable, possible, or unlikely benefit of IgG-replacement therapy. Summary and consensus-recommendations are provided for treatment indication, dosing, routes of administration, and adverse events of IgG-replacement therapy. Special aspects of concomitant impaired T-cell function are highlighted as well as clinical data on selected monogenetic inborn errors of immunity formerly classified into PADs (APDS, CTLA-4-, and LRBA-deficiency).
Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response
Creators: name: Heo, Muyoung
name: Shakhnovich, Eugene
Publisher: name: arXiv
Year: 2009
Subjects: subject: Biomolecules (q-bio.BM)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Dramatic rise of mutators has been found to accompany adaptation of bacteria in response to many kinds of stress. Two views on the evolutionary origin of this phenomenon emerged: the pleiotropic hypothesis positing that it is a byproduct of environmental stress or other specific stress response mechanisms and the second order selection which states that mutators hitchhike to fixation with unrelated beneficial alleles. Conventional population genetics models could not fully resolve this controversy because they are based on certain assumptions about fitness landscape. Here we address this problem using a microscopic multiscale model, which couples physically realistic molecular descriptions of proteins and their interactions with population genetics of carrier organisms without assuming any a priori fitness landscape. We found that both pleiotropy and second order selection play a crucial role at different stages of adaptation: the supply of mutators is provided through destabilization of error correction complexes or fluctuations of production levels of prototypic mismatch repair proteins (pleiotropic effects), while rise and fixation of mutators occur when there is a sufficient supply of beneficial mutations in replication-controlling genes. This general mechanism assures a robust and reliable adaptation of organisms to unforeseen challenges. This study highlights physical principles underlying physical biological mechanisms of stress response and adaptation.
title:  Outside the Picture Frame? The Case of the United Kingdom
Creators: name: Wallis  ,  Diana
Publisher: name: Roma TrE-Press
Year: 2021

description: Le giurisdizioni del Regno Unito – specificamente Inghilterra e Galles – hanno un approccio speciale nei confronti del diritto “straniero”. Il diritto dell’Unione europea non avrà tale status sino a quando il Regno Unito rimane Stato membro e viene tendenzialmente considerato come diritto interno. Una volta perfezionatasi la Brexit, tuttavia, è possibile che i giudici si aspettino che siano le parti a chiederne l’applicazione e rilevarlo in giudizio, e che prevalga la tendenza a considerarlo come un’entità estranea, a ‘sottovalutarlo’ e privilegiare l’applicazione del diritto inglese. Tuttavia, in tempi recenti il giudiziario e la professione forense hanno subito diverse ondate di ‘diversità’ che hanno contribuito ad un’ulteriore ‘europeanizzazione’ del diritto inglese e della pratica. Ciò si è verificato e continua a verificarsi a partire dall’ingresso nell’Unione europea, nel 1973. E’ auspicabile che il giudiziario e la professione giuridica inglese continuino a pensare che il diritto dell’Unione europea possa dare un contributo alla vita giuridica e ai sistemi di risoluzione delle controversie nel Regno Unito.
description: National Judges and the Case Law of the Court of Justice of the European Union
Electric field noise above surfaces: a model for heating rate scaling law in ion traps
Creators: name: Dubessy, Romain
name: Coudreau, Thomas
name: Guidoni, Luca
Publisher: name: arXiv
Year: 2008
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a model for the scaling laws of the electric field noise spectral density as a function of the distance, $d$, above a conducting surface. Our analytical approach models the patch potentials by introducing a correlation length, $ζ$, of the electric potential on the surface. The predicted scaling laws are in excellent agreement with two different classes of experiments (cold trapped ions and cantilevers), that span at least four orders of magnitude of $d$. According to this model, heating rate in miniature ion traps could be greatly reduced by proper material engineering.
9‐cis Retinoic acid and 1.25‐dihydroxyvitamin D 3 drive differentiation into IgA + secreting plasmablasts in human naïve B cells
Creators: name: Treptow, Sandra
name: Grün, Joachim
name: Scholz, Josephine
name: Radbruch, Andreas
name: Heine, Guido
name: Worm, Margitta
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: 9-cis retinoic acid
subject: B cell
subject: calcitriol
subject: IgA
subject: TGF-β
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Calcitriol and 9-cis retinoic acid (9cRA) play a fundamental role in shaping the adaptive immune response by altering the Ig profile and the differentiation of B cells, controlled by their corresponding nuclear receptors, VDR and RAR. Herein, after the establishment of a plasmablast differentiation culture, we investigated how both ligands modulate human naïve B cell differentiation and to which extent VDR/RXR and RAR/RXR signaling interferes. Calcitriol and 9cRA mediated activation of purified naïve B cells resulted in a strong differentiation of CD27+ CD38+ plasmablasts and antibody secretion. The significant IgA response was preceded by a strong induction of α-germline transcription (GLT). Induction of αGLT and consecutively IgA secretion driven by calcitriol is a novel observation and we show by magnetic chromatin IP that this was mediated by recruitment of the VDR to the TGF-β promoter thus inducing TGF-β expression. Finally, as revealed by transcriptomic profiling calcitriol and 9cRA modulate several signals required for differentiation and isotype switching in a noncompeting but rather additive manner. Calcitriol and 9cRA participate in the control of the IgA response in human activated naïve B cells. The balance between both ligands may be an important factor in channeling humoral immune responses toward a protective direction.
title: ÐÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð·Ð°Ð³Ð¾Ð»Ð¾Ð²ÐºÐ¾Ð² Ð¸Ð½ÑÐµÑÐ½ÐµÑ-Ð¡ÐÐ Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¶Ð°Ð½ÑÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: Ð¢Ð¸Ð¼ÑÐµÐ½ÐºÐ¾, ÐÐ¾Ð»Ð¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÑÐ¸ÑÑÐµÐ¼Ð° Ð¡ÐÐ
Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¶Ð°Ð½ÑÑ
ÑÐµÐ¿Ð¾ÑÑÐ°Ð¶
Ð¼ÐµÐ´Ð¸Ð°ÑÐµÐºÑÑ
ÑÐµÑÐµÐ²Ð¾Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¿Ð¾Ð½ÑÑÐ¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¸Ð½ÑÐµÑÐ½ÐµÑ-Ð¡ÐÐ, Ð¼ÐµÐ´Ð¸Ð°ÑÐµÐºÑÑÐ° Ð¸ ÑÐµÑÐµÐ²Ð¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÐµÐ´ÑÑÐ² ÑÐµÑÐµÐ²Ð¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ, ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²ÑÑÑÐ¸Ñ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÐºÐ¾Ð½ÑÐ»Ð¸ÐºÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ 100 Ð·Ð°Ð³Ð¾Ð»Ð¾Ð²ÐºÐ¾Ð² ÑÐ°ÐºÐ¸Ñ Ð¸Ð½ÑÐµÑÐ½ÐµÑ-Ð¡ÐÐ ÐºÐ°Ðº "Ð¤Ð¾Ð½ÑÐ°Ð½ÐºÐ°", "Ð ÐÐ Ð½Ð¾Ð²Ð¾ÑÑÐ¸", "Ð¢ÐÐ¡Ð¡"Ð¸ "ÐÐµÐ´ÑÐ·Ð°".
Physiology and pathophysiology of the RANKL/RANK system
Creators: name: Nicolin, Vanessa
name: Nori, Stefania Lucia
name: Bareggi, Renato
name: Narducci, Paola
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: osteoclasts; RANKL; OPG; clathrin

description: The bone resorption activity of osteoclasts is regulated at many levels, including differentiation of their monocytes precursors, fusion into multi-nucleated cells, migration to the resorption site, polarization of the mature osteoclasts and assembly of a podosome-based sealing zone. Another function of osteoclasts is relative to the integrity of the actin cytoskeleton, depending on the substratum upon which the osteoclasts are spread. There are two different structures of actin known as podosomes and sealing zone, actived in specialized matrix contacts and delimiting the membrane domain, where the ruffled border is formed. When a dual coculture of murine osteoblasts and murine mononuclear monocytes, in absolute absence of exogenous cytokines and other growth factors, was cultured on glass, the basic architecture of podosomes units and ruffled border was maintained regularly (1). We studied the osteoclast morphology and its behaviour in adhesion and in vesicle traffic by combination of light microscopy immunohistochemistry and transmission electron microscopy (TEM) immunolabeling. The adhesion and the fusion of preosteoclasts were observed by scanner electron microscopy (SEM). The osteoclasts produced by our physiological dual co-culture (without interaction of specific cytokines) are functionally and biologically active TRAP + and multinucleated cells. In fact the role of RANK, expressed by osteoblasts, controls the modulation of OPG bioavailability in the extracellular compartment. The fusion of monocytes is influenced by the presence of osteoblasts, that is based on RANK-RANKL interaction and communication between osteoblasts and preosteoclasts mediated by several molecules (2). Osteoclasts and osteoblasts can make direct contact, allowing membrane-bound ligands and receptors to interact and initiate intracellular signalling. RANKL-RANK complexes are likely internalized via rafts and then degraded in lysosomes. A recent study has shown that membrane-bound RANKL complexes to OPG is internalized by endocytosis process. A potential interaction of RANKL with clathrin components prior to the OPG binding, as shown by the kinetic results, OPG is intracellularly degraded after being internalized: our observation of osteoclast membrane at TEM has shown that immunogold labelled RANKL colocalizes with immunoglod labelled clathrin via the clathrin-coated-pit-mediated (3) pathway and both proteins are degraded by lysosome and proteasome pathway. 1) Nicolin V. et al.,. 2006 J.Mol.Histol.37 :171-177 2) Narducci P., et al.,. Acta Histochem.113(2):73-81. 3) Narducci P., et al., 2010, Eur J Histochem 54(1):e6.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis?
Creators: name: Wang, Zhao
name: Babina, Magda
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: allergy
subject: atopic dermatitis
subject: itch
subject: mast cell
subject: MRGPRX2
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The discovery of MRGPRX2 marks an important change in MC biology, explaining non-IgE-mediated clinical phenomena relying on MCs. As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology. Here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which support MCs and can be altered in skin disorders, and briefly touch on the functional programs elicited by MRGPRX2 ligation. Studies in Mrgprb2-deficient mice (the murine ortholog) help illuminate MRGPRX2's function in health and disease. Recent advances in this model support the long-suspected operational unit between MCs and nerves, with MRGPRX2 being a vital component. Based on the limited evidence for a major contribution of FcεRI/IgE-activated MCs to atopic dermatitis (AD), we develop the hypothesis that MRGPRX2 constitutes the missing link connecting MCs and AD, at least in selected endotypes. Support comes from the multifold changes in the MC-neuronal system of AD skin (eg greater density of MCs and closer connections between MCs and nerves, increased PAR-2/Substance P). We theorize that these deregulations suffice to initiate AD, but external triggers, many of which activating MRGPRX2 themselves (eg Staphylococcus aureus) further feed into the loop. Itch, the most burdensome hallmark of AD, is mostly non-histaminergic but tryptase-dependent, and tryptase is preferentially released upon MRGPRX2 activation. Because MRGPRX2 is a very active research field, some of the existing gaps are likely to be closed soon.
The PapCone® as a valid cervical sampling device: a comparative ultrastructural and semiquantitative study
Creators: name: Petruzziello, Luciano
name: Relucenti, Michela
name: D’Aluisio, Dayana
name: Iannaccio, Stefania
name: Giovagnoli, Maria Rosaria
name: Lukic, Ankica
name: Familiari, Giuseppe
name: Heyn, Rosemarie
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: pap test; uterine cervix; scanning electron microscopy; cervical cytology; transformation zone; endocervical cells

description: The efficiency of cervical cancer screening depends on the proper interpretation of results and on the quality of the sample. For a smear to be considered adequate, cell samples from the endocervix, transformation zone and ectocervix must be present. Our aim was to analyse cervicovaginal smears’ with scanning electron microscopy (SEM), comparing the traditional Ayre’s wooden spatula (Sp) and endocervical cytobrush (Cb) with a new cone-shaped polyurethane (foam) device, the PapCone®(Otto Bock, Duderstadt, Germany). Pap tests were performed with the related informed consent in 22 adult fertile (aged 20-46) women using Sp and/or Cb; sampling with the PapCone® followed 3 months after. The apical extremity of each device was fractured and fixed in toto in 2.5% glutaraldehyde containing vials. Samples were stored at 4°C, postfixed in 1% osmium tetroxide, dehydrated, critical-point dried, mounted on aluminum stubs, coated with platinum, and observed with a Hitachi S-4000 FE-SEM. Statistical analysis was performed evaluating ecto-/endocervical cells, erythrocytes, and/or mucus contained in ten 250x-microscopic fields. There were no significant differences in the number of ectocervical cells and in the quantity of mucus sampled when comparing the 3 devices. The PapCone® sampled significantly more endocervical cells with respect to Sp and Cb, and more erythrocytes with respect to the Sp. These latter data may be due to the characteristic porous and trabecular surface of the PapCone®, which samples a larger volume of material that tends to be also present in less overlapping layers. In conclusion, PapCone® is a better device with respect to Sp and Cb for sampling endocervical cells. Improved cervical sampling will certainly lead to better quality smears and hopefully decrease both false negative and inadequate smear rates.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
title: ÐÐ¾Ð½ÐµÑÐ½Ð¾-ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ½Ð¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¶ÐµÐ»ÐµÐ·Ð¾Ð±ÐµÑÐ¾Ð½Ð½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹ Ñ ÑÑÐµÑÐ¾Ð¼ Ð½ÐµÐ»Ð¸Ð½ÐµÐ¹Ð½ÑÑ Ð´Ð¸Ð°Ð³ÑÐ°Ð¼Ð¼ Ð´ÐµÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð²
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ¼ÐµÐ»ÑÑÑÐº, ÐÐ»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐÐµÑÐ¾Ð½Ð½ÑÐµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸
ÐÐµÐ»ÐµÐ·Ð¾Ð±ÐµÑÐ¾Ð½Ð½ÑÐµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸
ÐÐ¾Ð½ÐµÑÐ½ÑÑ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ¾Ð² Ð¼ÐµÑÐ¾Ð´
ÐÐ°Ð»ÐºÐ¸

description: Ð Ð½Ð°ÑÑÐ¾ÑÑÐµÐ¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð±ÐµÑÐ¾Ð½Ð½ÑÑ Ð¸ Ð¶ÐµÐ»ÐµÐ·Ð¾Ð±ÐµÑÐ¾Ð½Ð½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹, Ð° ÑÐ°ÐºÐ¶Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±Ñ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸Ñ ÐºÐ¾Ð½ÐµÑÐ½Ð¾-ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ñ ÑÑÐµÑÐ¾Ð¼ Ð½ÐµÐ»Ð¸Ð½ÐµÐ¹Ð½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð°, Ð¸Ð· ÐºÐ¾ÑÐ¾ÑÐ¾Ð³Ð¾ Ð¾Ð½Ð¸ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ñ. ÐÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¸ ÐºÐ¾Ð½ÐµÑÐ½Ð¾-ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ½Ð¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸ Ð¾Ð± Ð¸Ð·Ð³Ð¸Ð±Ðµ ÑÐ°ÑÐ½Ð¸ÑÐ½Ð¾-Ð¾Ð¿ÐµÑÑÐ¾Ð¹ Ð±Ð°Ð»ÐºÐ¸ Ð¿Ð¾Ð´ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¸Ð¼Ð¿ÑÐ»ÑÑÐ½Ð¾Ð¹ Ð½Ð°Ð³ÑÑÐ·ÐºÐ¸. ÐÐ¾Ð½ÐµÑÐ½Ð¾-ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ½Ð¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¾ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ ABAQUS Ð² 2D Ð¸ 3D Ð¿Ð¾ÑÑÐ°Ð½Ð¾Ð²ÐºÐ°Ñ Ð·Ð°Ð´Ð°ÑÐ¸ Ð´Ð»Ñ Ð±ÐµÑÐ¾Ð½Ð½Ð¾Ð¹ Ð¸ Ð¶ÐµÐ»ÐµÐ·Ð¾Ð±ÐµÑÐ¾Ð½Ð½Ð¾Ð¹ Ð±Ð°Ð»ÐºÐ¸ Ð¿ÑÐ¸ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ°Ñ Ð½Ð°Ð³ÑÑÐ·ÐºÐ¸. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÐ¾Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð².
Dopamine D3 receptor modulates tissue type plasminogen activator (tPA) activity in mouse brain
Creators: name: Castorina, Alessandro
name: Leggio, Gian Marco
name: D’Amico, Agata Grazia
name: Scuderi, Soraya
name: Drago, Filippo
name: Carnazza, Maria Luisa
name: D’Agata, Velia
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: BDNF; dopamine D3 receptor; tissue plasminogen activator; BDNF

description: Growing amount of evidence points to the dopamine D3 receptor (D3R) as an important mediator in the broad array of events that regulate memory function, perhaps through the modulation of molecular pathways involved in neurotrophic factor activation. Tissue type plasminogen activator (tPA) is a proteolytic enzyme that cleaves the precursor of brain derived neurotrophic factor (proBDNF) into the biologically active form of mature BDNF. However, whether D3Rs modulate tPA activity on BDNF in brain has not been ascertained yet. Here in the present study, using D3R knock-out (D3-/-) mice, we demonstrate that receptor inactivation is associated with increased tPA expression both in prefrontal cortex and, to a greater extent, in the hippocampus, two regions associated with memory processes. The heightened tPA levels observed in D3-/- mice inversely correlated with proBDNF protein expression, whereas they positively correlated with both BDNF mRNA and mature BDNF protein levels. In conclusion, our finding strongly suggest that D3Rs might modulate tPAmediated post-transcriptional processing of BDNF in brain regions critical to memory function.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Loop Quantum Cosmology and Spin Foams
Creators: name: Ashtekar, Abhay
name: Campiglia, Miguel
name: Henderson, Adam
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Loop quantum cosmology (LQC) is used to provide concrete evidence in support of the general paradigm underlying spin foam models (SFMs). Specifically, it is shown that: i) the physical inner product in the timeless framework equals the transition amplitude in the deparameterized theory; ii) this quantity admits a %convergent vertex expansion a la SFMs in which the $M$-th term refers just to $M$ volume transitions, without any reference to the time at which the transition takes place; iii) the exact physical inner product is obtained by summing over just the discrete geometries; no `continuum limit' is involved; and, iv) the vertex expansion can be interpreted as a perturbative expansion in the spirit of group field theory. This sum over histories reformulation of LQC also addresses certain other issues which are briefly summarized.
description: 11 pages, no figures
Data mining for systems medicine and spectroscopic profiling: methods and applications
Creators: name: Zounemat Kermani, Nazanin
Publisher: name: Imperial College London
Year: 2020

description: With the advent of analytical technologies that quantify the biological and chemical compartments of health and disease in a high throughput manner; there has been a pressing need for computational pipelines to harness the power of these wealth of data. The focus of the thesis was on developing statistical and computational methods and pipelines to pre-process spectroscopic profiling data and to analyse and integrate omics data with the aim of disease phenotyping. We showed that systems medicine with the aim of stratification of patients is a progressively multidisciplinary that can benefit from computational and statistical methods drawn from various fields such as computer science, statistics and information theory. It has been increasingly common to acquire multiple omics data from multiple tissue and bio-fluid to understand complex diseases with heterogeneous response to treatments. The goal of such comprehensive studies is to gain systematic insights into the disease mechanism through the lens of multiple omics data sets. An impediment to reach the considerable potential of these technologies is the lack of computational and statistical methods and pipelines to process the mountain of data that they generate. Each data set depending on its underlying technology posses different challenges. Some require robust per-processing techniques for improved information gain and some passed this phase and require to be coupled with complementary data for improved knowledge discovery. An example of the former is the mass spectrometry imaging and an example of the later is transcrimptomics. In the thesis we investigated pre-processing methods for mass spectrometry imaging data. A hierarchical clustering methods is optimised to stand the challenge of big MSI data set. A spatial statistical pipeline was designed and implemented for MSI to minimise information loss during pre-processing. A challenge in systems medicine is to integrate multiple omics data sources to provide a comprehensive insight into the disease mechanism This thesis proposed a multi-layer pipeline that incorporated methods from bioinformatics, statistics and machine learning fields to successfully integrate multi-omics data and generated clinically relevant subphenotypes for sever asthma.
Proliferative events experimentally induced by transient cold shock in the brain of adult terrestrial heterothermic vertebrates: preliminary analysis of PCNA expression in Triturus carnifex
Creators: name: Chimenti, Claudio
name: Margotta, Vito
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: adult newt; brain; cold shock; PCNA expression

description: Experimental procedures used to investigate the persistence, location and abundance of scattered (“matrix cells”) and/or clustered (“matrix areas”) stem cells in the brain, responsible for proliferation in adult terrestrial heterothermic vertebrates have included an induced transient drop in body temperature in specimens subsequently deprived of encephalic areas. In a set of coordinated investigations focused on the influence of an exposure to a drastic thermally environment on these activities, we gave priority to Triturus carnifex, since there is a much larger amount of detailed, unequivocal experimental evidence available for this species than for other vertebrates of the same evolutionary level. In the present study, cold-shocked newts were examined after a stay at external temperature (the most suitable one based on previous experience) to allow the maximal expression of cerebral proliferation. In a qualitative evaluation, the brain of experimental specimens compared with that of normal individuals seemed not to show, contrary to expectations, more pronounced cell proliferation as assessed by Proliferat- ing Cell Nuclear Antigen immunolabelling of neural-like cells in the S phase of cell cycle. This discrepancy with previous reports from other authors may depend on having used cold stress alone, while other traumatic stimuli (operatory shock, encephalic injury) administered by the previous authors might have induced a greater number of cells to move from a stand-by condition to proliferation, allowing for reparative and/or regenerative phenomena.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (2013)
Predicting surface roughness in machining aluminum alloys taking into account material properties
Creators: name: Nguyen, Van-Hai
name: Le, Tien-Thinh
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: This study investigates the use of machine learning models to predict surface roughness (Ra) in milling multi-grade aluminum alloys without prior knowledge of optimal cutting parameters. A diverse milling dataset encompassing material properties and cutting parameters from various aluminum alloy grades was compiled from research articles. Four machine learning algorithms, Extreme Gradient Boosting (XGB), Random Forest (RFR), Catalogical Gradient Boosting (CAT), and Gradient Boosting Regression (GBR), were employed to develop the predictive model. The dataset underwent cleaning, imputation, and outlier removal to ensure data quality. Feature engineering incorporated material properties and cutting parameters for model training. Performance metrics such as RMSE, MAPE, and R2 were used to assess the models’ accuracy. The SHapley Additive exPlanations (SHAP) technique was employed to interpret the models and identify influential features. GBR achieved the highest prediction accuracy with an RMSE of 0.2507 µm, MAPE of 23.36%, and R2 of 0.8709. Thermal conductivity, feed rate, and cutting speed were consistently identified as the most influential factors, although their rankings differed slightly. This study successfully developed a GBR model for effective Ra prediction in aluminum alloy milling, supporting advancements in smart manufacturing by enabling accurate surface quality prediction and data-driven process optimization through machine learning.
Plasmonic enhanced photoelectrochemical water splitting by hematite-based nanocomposites
Creators: name: Jiang, Qianfan
Publisher: name: Imperial College London
Year: 2020

description: As a promising solar energy harvesting technology, artificial solar water splitting enables direct solar-to-hydrogen conversion and thus exhibits huge potential in the field of alternative energy source. Hematite is one of the most common photoactive semiconductors and can be utilized as photoanodes in photoelectrochemical water splitting systems. Despite being non-toxic, cost-efficient and earth-abundant, pristine hematite has poor light harvesting efficiency. Various strategies to improve the efficiency are essential for hematite photoanodes. Plasmonic enhancement that employs plasmonic nanostructures for enhanced electromagnetic field is one of the promising approaches to boost the solar water splitting performance of hematite. This PhD project focused on the implementation of plasmonic enhancement in hematite photoanodes, together with other optimization strategies such as nanostructuring, surface modification and upconversion. Modelling work was carried out as a theoretical framework to guide plasmonic nanostructures’ design. In particular, FDTD modelling for plasmonic nanodisk arrays, nanotriangle arrays and nanohole arrays were carried out to identify their plasmonic resonance wavelength as well as the spatial distribution of the enhanced field. Plasmonic nanohole arrays were chosen as the best candidates to be utilized in solar water splitting systems due to the significantly enhanced field originated from surface plasmon polaritons. Various novel plasmonic nanohole arrays including dual-layer nanohole arrays and non-noble, aluminum-based nanohole arrays are fabricated and applied to hematite photoanodes. Improved photocurrent density can be observed due to plasmonic enhancement. Furthermore, plasmonic enhanced triplet-triplet annihilation upconversion nanoparticles that can convert low-energy photons to high-energy photons were utilized to overcome the limitation of hematite's bandgap. The concepts of plasmonic enhanced upconversion and upconversion induced solar water splitting were proven by observing below-bandgap enhancement in incident photon-to-current efficiency measurements. This work not only demonstrated the feasibility of implementing plasmonic enhancement in hematite photoanodes but also paved the way towards employing plasmonic nanostructures in other solar water splitting devices.
Effects of relaxin in a co-culture of Sertoli and germ cells
Creators: name: Porto, Catarina S.
name: Porto, Catarina S.
name: Lazari, Maria F.M.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Spermatogenesis is controlled by FSH, testosterone and paracrine factors produced by Sertoli cells. The knockout of relaxin decreases sperm maturation in mice. Studies from our laboratory have shown that relaxin and its receptor RXFP1 are expressed in rat Sertoli cells, and exogenous relaxin stimulates Sertoli cell proliferation. Relaxin receptors are also detected in the rat germ cells at specific stages of development. Relaxin could therefore affect spermatogenesis either indirectly, by stimulating Sertoli cell proliferation, or directly, by affecting germ cells. The aim of the present study was to explore a role of relaxin at specific stages of spermatogenesis using a co-culture of rat Sertoli and germ cells. Relaxin seems to increase the number of pre-meiotic and meiotic cells.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013
title: ÐÐ½Ð°Ð»Ð¸Ð· ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¸ Ð¾ÑÐµÐ½ÐºÐ° Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð² ÐµÐ³Ð¾ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð¢Ð¸ÑÐ°ÑÐµÐ½ÐºÐ¾, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÐµÑÑÑÑÐ½ÑÐ¹ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»
ÑÐ¾Ð·Ð½Ð¸ÑÐ½Ð¾Ðµ ÑÐ¾ÑÐ³Ð¾Ð²Ð¾Ðµ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ðµ
Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÐµ ÑÐµÑÑÑÑÑ
ÑÑÑÐ´Ð¾Ð²ÑÐµ ÑÐµÑÑÑÑÑ
ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²ÑÐµ ÑÐµÑÑÑÑÑ
ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¾ÑÑÐ°Ð²Ð°, Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸ Ð¸ ÑÑÑÑÐºÑÑÑÑ ÐºÐ°Ð¿Ð¸ÑÐ°Ð»Ð°, Ð²Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð² Ð¸Ð¼ÑÑÐµÑÑÐ²Ð¾ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸. ÐÑÑÐ°Ð¶ÐµÐ½Ð° Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ° Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÐµÐ¹Ð»Ð¸ÐºÐ²Ð¸Ð´Ð½Ð¾ÑÑÐ¸, Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð¾ÑÐµÐ½ÐºÐ° ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ ÐÐÐ Â«Ð¡Ð¾ÑÐ·Â». ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð¾ÑÐµÐ½Ð¾ÑÐ½ÑÐµ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð±Ð°Ð½ÐºÑÐ¾ÑÑÑÐ²Ð°. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÑÑÐ°ÑÐµÐ³Ð¸Ñ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ SWOT-Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ñ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÐµÐµ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸. Ð Ð°ÑÑÑÐ¸ÑÐ°Ð½ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð½ÑÐ¹ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÑÐµÐºÑ Ð¾Ñ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð°Ð²ÑÐ¾ÑÑÐºÐ¸Ñ ÑÐ°ÑÑÐµÑÐ¾Ð².
Sox2 induces Mesenchymal to Epithelial transition in somatic cells
Creators: name: Campolo, Federica
name: Dolci, Susanna
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: During late embryonic development mesodermal cells generate epithelial organs, such as kidney and ovary, via a process named Mesenchymal to Epithelial Transition (MET) (1). This process can also occur reversely giving rise to Epithelial to Mesenchimal transition (EMT) (2), which represents the mechanism by which metastasis originate from primary tumors. Many lines of evidence underlie a continuous interaction between these two programs. Indeed MET is believed to participate in the establishment and stabilization of distant metastases by allowing cancerous cells to regain epithelial properties and integrate into distant organs. It has been shown that fibroblasts undergo MET at some point during reprogramming to mimic undifferentiated ESCs (2).Since SOX2 is an essential factor to reprogram somatic cells to stem cell fate, we investigated if it might play a role in inducing MET in mouse embryonic fibroblasts. Using a lentiviral vector we found that Sox2 transduced cells changed morphology as early as two days after infection compared to their mock infected controls. Although cells showed an epithelial-like morphology, they were E-cadherin negative. Furthermore, Sox2 negatively regulated the expression of some of the mTOR pathway such as 4EBP1, EIF4E and S6. FACS analysis in Sox2-transduced somatic cells also revealed a cell cycle arrest in G1-phase. Together our data suggest a role of Sox2 in cell fate and commitment.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Summing Planar Open String Loops on a Worldsheet Lattice with Dirichlet and Neumann Boundaries
Creators: name: Thorn, Charles B.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We extend the lightcone worldsheet lattice approach to string theory, proposed in 1977 by Giles and me, to allow for coincident D-branes. We find a convenient lattice representation of Dirichlet boundary conditions, which the open string coordinates transverse to the D-branes satisfy. We then represent the sum over all planar open string multi-loop diagrams by introducing an Ising spin system on the worldsheet lattice to keep track of the presence or absence of fluctuating boundaries. Finally we discuss a simple mean field treatment of the resulting coupled Ising/coordinate worldsheet system. The interplay between Neumann and Dirichlet boundary conditions leads to a richer phase structure, within this mean field approximation, than that found by Orland for the original system with only Neumann conditions.
description: 16 pages 6 figures
Additional file 1 of Balance training benefits chronic ankle instability with generalized joint hypermobility: a prospective cohort study
Creators: name: Hou, Zong-chen
name: Ao, Ying-fang
name: Hu, Yue-lin
name: Jiao, Chen
name: Guo, Qin-wei
name: Li, Nan
name: Jiang, Yan-fang
name: Jiang, Dong
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Mental Health

description: Additional file 1:  Appendix A. Balance training protocol.
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² Ð¸ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ 500/330 ÐºÐ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÑÐ¼Ð°ÐºÐ¸Ð½, ÐÐ¸ÐºÐ¸ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÑÑÑÐ°Ð½Ð¾Ð²Ð¸Ð²ÑÐ¸Ð¹ÑÑ ÑÐµÐ¶Ð¸Ð¼
Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ñ
Ð¼ÐµÑÐ¾Ð´ ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸ÑÐ½ÑÑ ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑÐ¸Ñ
Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÐµÐ³ÑÐ»ÑÑÐ¾Ñ Ð²Ð¾Ð·Ð±ÑÐ¶Ð´ÐµÐ½Ð¸Ñ

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² Ð¸ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÑÐ¾Ð¹ÑÐ¸Ð²Ð¾ÑÑÐ¸ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ 500/330 ÐºÐ. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¾ Ð²ÑÐ±ÑÐ°Ð½Ð¾ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð² ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ð¸ Ñ Ð¸ÑÑÐ¾Ð´Ð½ÑÐ¼Ð¸ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸, Ð±ÑÐ» Ð¿ÑÐ¾Â¬Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ ÑÑÑÐ°Ð½Ð¾Ð²Ð¸Ð²ÑÐµÐ³Ð¾ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð° ÑÐ¸ÑÑÐµÐ¼Ñ Ð²ÑÑÑÐ½ÑÑ Ð¸ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ RastrWin. ÐÑÐ¸ ÑÑÑÐ½Ð¾Ð¼ ÑÐ°ÑÑÐµÑÐµ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°Ð»ÑÑ ÑÐµÐ¶Ð¸Ð¼ Ð¼Ð°ÐºÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ Ð½Ð°Ð³ÑÑÐ·Ð¾Ðº, Ð° Ð¿ÑÐ¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° ÐµÑÐµ Ð¸ ÑÐµÐ¶Ð¸Ð¼ Ð¼Ð¸Ð½Ð¸Ð¼Ð°Ð»ÑÐ½ÑÑ Ð½Ð°Ð³ÑÑÐ·Ð¾Ðº.
ÐÐ¾ÑÐ»Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÑÑÐ°Ð½Ð¾Ð²Ð¸Ð²ÑÐ¸ÑÑÑ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² Ð±ÑÐ» Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ Ð´Ð²ÑÑÑÐ°Ð·Ð½Ð¾Ð³Ð¾ ÐºÐ¾ÑÐ¾ÑÂ¬ÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¼ÑÐºÐ°Ð½Ð¸Ñ Ð½Ð° Ð·ÐµÐ¼Ð»Ñ. ÐÑÐ¸ ÑÑÐ¾Ð¼ Ð±ÑÐ» Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½ Ð¼ÐµÑÐ¾Ð´ ÑÐ¸Ð¼Ð¼ÐµÑÑÐ¸ÑÐ½ÑÑ ÑÐ¾Â¬ÑÑÐ°Ð²Ð»ÑÑÑÐ¸Ñ, Ð° ÑÐ°Ðº Ð¶Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÐºÐ¾ÑÐ¾ÑÐºÐ¾Ð³Ð¾ Ð·Ð°Ð¼ÑÐºÐ°Ð½Ð¸Ñ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¼ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ Dymola.
ÐÐ° ÑÑÐ°Ð¿Ðµ ÑÐ°ÑÑÐµÑÐ¾Ð² ÑÑÑÐ°Ð½Ð¾Ð²Ð¸Ð²ÑÐµÐ³Ð¾ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð° Ð±ÑÐ» Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½ Ð²Ð°ÑÐ¸Ð°Ð½Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐµÐ¶Ð¸Ð¼Ð° Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÐ¾Ð¼Ð¿ÐµÐ½ÑÐ¸ÑÑÑÑÐ¸Ñ ÑÑÑÑÐ¾Ð¹ÑÑÐ². Ð ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐµÐºÐ°Ð½Ð¸Ñ Ð¿ÐµÑÐµÑÐ¾Ð´Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°, Ð° Ð¸Ð¼ÐµÐ½Ð½Ð¾ ÐµÐ³Ð¾ ÑÐºÐ¾ÑÐµÐ¹ÑÐµÐ³Ð¾ Ð·Ð°Ð²ÐµÑÑÐµÐ½Ð¸Ñ, Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð°ÑÑÑÐ¾Ð¹ÐºÐ° Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐµÐ³ÑÐ»ÑÑÐ¾ÑÐ° Ð²Ð¾Ð·Ð±ÑÐ¶Ð´ÐµÐ½Ð¸Ñ Ð³ÐµÐ½ÐµÑÐ°ÑÐ¾ÑÐ¾Ð².
Cryogenic temperature protects biological material from gamma ray induced effects
Creators: name: Cugia, Giulia
name: Centis, Filippo
name: Dattena, Maria
name: Del Zotto, Genny
name: Lucarini, Alessandra
name: Bonelli, Piero
name: Sanna, Daniela
name: Argazzi, Elisabetta
name: Bono, Monica
name: Zini, Giampaolo
name: Valentini, Massimo
name: Picardi, Francesco
name: Cesarini, Werther
name: Zamai, Loris
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2010
Subjects: Gamma radiation; cryopreservation; cell death; embryo; abortion

description: Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement) 2010
Active network management for improved flexibility in distribution networks
Creators: name: Perez Olvera, Julio
Publisher: name: Imperial College London
Year: 2020

description: Decarbonisation efforts have prompted the rapid uptake of low-carbon technologies (LCTs) in distribution networks. Their power use and delivery are highly variable and can cause various voltage-regulation and thermal-overload problems, thus making it difficult to maintain a secure operation of these networks. The problem is compounded by the lack of instrumentation in low-voltage networks. Two specific problems are identified: 1) the need for greater flexibility in power routing in distribution networks and 2) the need for optimising controllers operating with partial visibility of the network state and with practical computational efficiency. Power flow flexibility is provided by AC/DC power electronic converters and DC links, as part of an Active Network Management (ANM) scheme. An Optimal Power Flow (OPF) algorithm is modified to include DC links and serves as a benchmark for dispatching the DC power flows but is deemed too computationally intensive for real-time control. Alternatives to the OPF, based on regression and reinforcement learning, were examined using casestudy networks. Regression mapping of the OPF output is proposed to move the computational effort offline and to address the partial observability of the network. However, it was found to have poor accuracy and a limited ability to generalise. For better generalisation and accuracy, a model-free reinforcement learning method based on deep Q networks was proposed. The performance was on a par with the OPF while being able to generalise to different loading conditions, however the training required several hours. A model-based algorithm using an explicit model of the network was proposed to further improve the accuracy and reduce the computational burden. The training time was in the range of minutes with good accuracy compared to the OPF. ANM using power converters together with controllers based on reinforcement learning represent a compelling alternative to further integrate LCTs in distribution networks.
Hymedesmia undefined-4
Creators: name: Pereira, Raquel
name: Larsson, Mats
name: Cárdenas, Paco
name: Thollesson, Mikael
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Poecilosclerida
Hymedesmiidae
Hymedesmia
Hymedesmia undefined-4

description: Hymedesmia sp. 4
Fig. 21
Material examined
SWEDEN • 1 spec.; Yttre Vattenholmen; 58.8754° N, 11.1056° E; 27 m depth; 16 Nov. 2019; Mats Larsson leg. [MM-191116-2]; SCUBA; LAR-191116-PB160433, 35; GenBank no.: OM415632 (28S D3-D5); voucher: GNM Porifera 1049.
Description
The specimen, of which a 5 mm fragment was collected, presents an encrusting morphology, growing on rock covered with coralline algae. The colour alive of the specimen is orangish-yellow presenting white dots that are possibly embryos (Fig. 21A). Its colour in ethanol is beige. The specimen does not present evident osculum, pore-sieves nor pores. The consistency is very fragile after being preserved in ethanol.
Skeleton
Skeleton composed of two size classes of acanthostyles: a) large acanthostyles with a small base, spines covering 1/3 of the length, some spines seem poorly formed by being extremely thin in the shaft, measuring 212.5– 239. 1 –270.4 ± 23.37 × 4.1– 6.7 –10.1 ± 2.7 µm (N = 5), b) small acanthostyles are fully spined (Fig. 21B) and have a well-developed tyle at base, measuring: 104.– 116.3– 138.2 ± 9.32 × 3.4– 5.3 –7.8 ± 1.60 µm (N = 11) (Fig. 20B). Additionally, the skeleton also presents a single class size of anisostrongyles measuring 124.2– 220.9 –287.5 ± 26.32 × 0.8– 1.8 –4.6 ± 0.66 µm (N =46) (Fig. 21C).
Remarks
The specimen examined presents a peculiar external morphology by lacking apparent structure on its surface. However, given the presence of several ‘white dots’, it is possible that the specimen is riddled with embryos and has lost its usual external morphology. The specimen does not present any nucleotide difference in the 28S D3-D5 sequences, when compared with other specimens identified as H. hibernica (Fig. 2). However, the lack of pore-sieves and the presence of small acanthostyles, thinner than what is reported for H. hibernica leads us to keep this specimen as Hymedesmia sp.
description: Published as part of Pereira, Raquel, Larsson, Mats, Cárdenas, Paco & Thollesson, Mikael, 2025, Swedish marine demosponge fauna (Porifera: Demospongiae) sampled 80 years after Jägerskiöld's inventory, pp. 1-64 in European Journal of Taxonomy 983 on pages 43-44, DOI: 10.5852/ejt.2025.983.2835, http://zenodo.org/record/15168665
title: Ð¤Ð¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾ÑÑÑÐµÐ»Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð² ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÐ°ÑÑÐ¸ÑÐµÐ½Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÐÐ½ÑÐ¾ÑÑÐ°
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: Ð¡ÑÐµÐ»ÑÐ¼Ð°ÑÑÐº, ÐÐ½ÑÐ¾Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾ÐµÐºÑÐ°Ð¼Ð¸
ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¼ÐµÐ½ÐµÐ´Ð¶Ð¼ÐµÐ½Ñ
Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¿ÑÐ¾ÐµÐºÑÑ
project management
strategic management
innovative projects

description: ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¿ÑÐ¾ÑÐµÑÑÐ° ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ÑÑÑÐµÐ»Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð², Ð° ÑÐ°ÐºÐ¶Ðµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð¿ÑÐ¾ÑÐµÑÑÐ° ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ¸ÑÐºÐ°Ð¼Ð¸ Ð¿Ð¾ÑÑÑÐµÐ»Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð². ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° ÑÐ°ÑÑÐ¸ÑÐµÐ½Ð½Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ ÐÐ½ÑÐ¾ÑÑÐ° Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¿ÑÐ¾ÑÐµÐ´ÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð² Ð¿ÑÐ¾ÑÐµÑÑÐµ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ÑÑÑÐµÐ»Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð². Ð ÑÐ°Ðº Ð¶Ðµ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸. ÐÐ¾Ð²Ð¸Ð·Ð½Ð° Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð² Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð° Ð°Ð½Ð°Ð»Ð¸Ð·Ð¾Ð¼ Ð½Ð°ÑÑÐ½Ð¾-Ð¼ÐµÑÐ¾Ð´Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ.
From Russia with Love
Creators: name: Foletti, Ivan
name: Rakitin, Pavel
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2018

description:

The article investigates the perception of the cultural and artistic production of the Southern Caucasus, after the annexation of Georgia in 1801, by three highly educated intellectuals of the time: the Metropolitan Evgeniy Bolkhovitinov, the historian Platon Ioseliani and the artist and architect Grigory Gagarin. Their writings reveal a latent concept of historical pre-eminence of the Caucasian region, and Georgia in particular, as a cultural and sacred outpost of two countries, the Byzantine Empire and the Empire of the Russian Monarchs of the 19th century.

description: Venezia Arti
Persistent Homology for Random Fields and Complexes
Creators: name: Adler, Robert J.
name: Bobrowski, Omer
name: Borman, Matthew S.
name: Subag, Eliran
name: Weinberger, Shmuel
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 60G15, 55N35 (Primary), 60G55, 62H35 (Secondary)

description: We discuss and review recent developments in the area of applied algebraic topology, such as persistent homology and barcodes. In particular, we discuss how these are related to understanding more about manifold learning from random point cloud data, the algebraic structure of simplicial complexes determined by random vertices, and, in most detail, the algebraic topology of the excursion sets of random fields.
Additional file 2 of Balance training benefits chronic ankle instability with generalized joint hypermobility: a prospective cohort study
Creators: name: Hou, Zong-chen
name: Ao, Ying-fang
name: Hu, Yue-lin
name: Jiao, Chen
name: Guo, Qin-wei
name: Li, Nan
name: Jiang, Yan-fang
name: Jiang, Dong
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Science Policy
subject: Mental Health

description: Additional file 2:  Supplementary Table 1. Comparison of balance between groups.