cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting the Myc oncoprotein
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Aberrant overexpression of the c-Myc (Myc) oncoprotein, a transcription factor, is estimated to be involved in approximately 70 % of all human cancers. Yet, despite it’s profound importance, there are no clinical agents that directly target and inhibit Myc. Efforts to develop small molecule Myc inhibitors have been hindered by a lack of suitable binding pockets on the protein. Hence, Myc, like other transcription factors, has been considered “undruggable”. We propose to take an entirely different approach to develop a Myc inhibitor. Our approach will be based on the mechanism of Myc action and our prior success in developing a novel inhibitor of the “undruggable” transcription factor STAT3. Myc exerts it’s effects by first heterodimerizing with Max. Myc/Max then recognizes a unique, consensus DNA response element found in the promoter regions of Myc target genes. Following binding to these response elements, Myc/Max induces the transcription of target genes that promote oncogenesis and resistance to chemotherapy, radiation, and immunotherapy. STAT3 oncoprotein similarly recognizes it’s own unique DNA response element. We previously generated a potent, selective, and well-tolerated STAT3 inhibitor that mimics the STAT3 DNA response element, and is called cyclic STAT3 decoy (CS3D). CS3D is a 15-bp double-stranded DNA molecule that is cyclized at both ends with hexaethylene glycolyl linkers. CS3D binds STAT3 and competitively inhibits STAT3 binding to the promoter region of target genes, shutting down expression of these genes. CS3D inhibits the proliferation of cancer cells and the growth of xenograft tumors following systemic delivery. We hypothesize that cyclic oligonucleotide decoys can be developed to target and inhibit Myc/Max. Three Aims are proposed. In Aim 1 we will generate and optimize cyclic oligonucleotide decoys targeting Myc/Max and the functional capacity of the cyclic decoys to bind Myc/Max will be determined. The optimal length and the specificity of each cyclic decoy will also be determined. Aim 2 will determine the ability of an optimized Myc/Max cyclic decoy to inhibit Myc-mediated transcription using Myc/Max reporter constructs and a scrambled sequence version of the cyclic decoy as a control. Aim 3 will investigate the growth inhibitory and pro-apoptotic properties of the Myc/Max cyclic decoy in Myc-dependent cells.
Additional file 3 of Serratia marcescens in the intestine of housefly larvae inhibits host growth by interfering with gut microbiota
Creators: name: Li, Ying
name: Wang, Shumin
name: Zhang, Kexin
name: Yin, Yansong
name: Zhang, Xinyu
name: Zhang, Qian
name: Kong, Xinxin
name: Tang, Luyao
name: Zhang, Ruiling
name: Zhang, Zhong
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 3: Figure S1. Annotated genome maps for the phage SMP. In the circular genome map, the outermost black circle represents the full length of the genome, the innermost multicolored circle represents annotated functional proteins, the second outermost blue circle represents the GC skew, and the third outermost purple circle represents the GC skew content.
Seeing the obscure for non-small cell lung cancer radiotherapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Locoregional failure (LRF) is a frequent challenge in patients treated with radio-chemotherapy for locally advanced non-small cell lung cancer. LRF has been observed in about 45% of ablative radiotherapy recipients in the recent PACIFIC trial. These indicate that remission rate may be reduced by either local boosting in the definitive radiotherapy or focal salvage treatment. These failure patterns also allude to the criticality in ensuring that the ablative dose has been actually delivered to the intended treatment volume, a question to be answered with sophisticated monitoring that is currently absent. In this project, we propose to work with the widely accessible x-ray based on-board imaging (OBI) system. As X-ray collapses attenuation information along the beam direction, there is depth uncertainty and compromised conspicuity of the tumor target. Furthermore, the OBI is configured at a fixed angle to the treatment megavoltage beam, so its view angle is passively determined by the treatment trajectory, and typically does not offer the best visibility for tumor target or surrounding tissue context. The suboptimal region-of-interest (ROI) visibility is further compounded with the obstruction of high attenuating structures such as the rib(cage) along the x-ray beamline, drowning important lung texture. To facilitate both online monitoring of the thorax anatomy, and spatiotemporal dose integration as quantitative evidence for adaptive SBRT, we will tailor neural field learning development with x-ray physics and geometry to (1) develop a physics and geometry informed view toggler to translate an online acquired OBI x-ray image to a clinically favorable angle with high GTV and context conspicuity (2) develop a virtual rib removing network to reveal the lung texture, and (3) Expand view toggler to full volumetric synthesizer to generate spatiotemporal anatomy for radiation dose accumulation. Success of this project will fill in the knowledge and clinical gap in fully monitoring the thorax dynamics during lung radiotherapy treatment, which has hindered the development and utilization of real-time adaptive control. Accurate spatiotemporal dose accumulation not only provide informed prescription adaption but also provides more accurate actual dose to support radiobiological and outcome analysis to improve treatment regimen design.
Online_Supplements – Supplemental material for Psychological Ownership: A Meta-Analysis and Comparison of Multiple Forms of Attachment in the Workplace
Creators: name: Zhang, Yucheng
name: Liu, Guangjian
name: Zhang, Long
name: Xu, Shan
name: Cheung, Mike W.-L.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Organisation and Management Theory

description: Supplemental material, Online_Supplements for Psychological Ownership: A Meta-Analysis and Comparison of Multiple Forms of Attachment in the Workplace by Yucheng Zhang, Guangjian Liu, Long Zhang, Shan Xu and Mike W.-L. Cheung in Journal of Management
اثربخشی آموزش پیش از ازدواج بر باورهای ارتباطی، خودکار آمدی و معناجویی در دانشجویان پرستاری
Publisher: name: دانشگاه کردستان
Year: 2020

description: آموزش پیش از ازدواج یکی از اولویتهای اصلی در برنامه های جلوگیری از ناهنجاریهای فردی و خانوادگی \nکاهش میزان طلاق و افزایش خوشنودی زناشویی است. هدف از پژوهش حاضر اثربخشی آموزش پیش از ازدواج \nبر باورهای مرتبط با رابطه، خودکارآمدی و معنای زندگی در دانشجویان پرستاری تبریز بود. روش پژوهش نیمه \nآزمایشی با طرح پیش آزمون و پس آزمون با گروه گواه بود. جامعه آماری دانشجویان پرستاری مقطع کارشناسی \nدانشگاه علوم پزشکی شهر تبریز در سال تحصیلی 9۶-9۷ دربرگیرنده 5۶0 نفر بودند. آزمودنیها به تعداد 40\nنفر بودند که به روش نمونه گیری تصادفی از میان دانشجویانی که درخواست کننده شرکت در این دوره بودند \nانتخاب گردیده و در دو گروه 20 نفری آزمایش و گواه گمارده شدند. گروه آزمایش در ۶ جلسه ۶0 دقیقه ای \nآموزش پیش از ازدواج به روش انجل و رایت دریافت کردند و گروه گواه هیچ آموزشی دریافت نکرد. داده ها با \nبه کارگیری سنجه های باورهای مرتبط با رابطه ( 1982, Epstein & Eielson ،(خودکارآمدی & Schwarzer(\n(1995, Jerusalem و معنا در زندگی (2006., al et Steger (گردآوری شد. جهت تجزیه وتحلیل دادهها در بخش \nآمار توصیفی از توزیع فراوانی، میانگین و انحراف معیار و در بخش استنباطی از تحلیل کوواریانس چند متغیره \nاستفاده شد. نتایج نشان داد اثربخشی برنامه آموزشی پیش از ازدواج بر باورهای مرتبط با رابطه، خودکارآمدی و \nمعنای زندگی معنیدار بوده است )0001>p .)با توجه به نتایج پژوهش میتوان گفت که به کارگیری این \nآموزش پیش از ازدواج بر روی باورهای مرتبط با رابطه ، خودکارآمدی و معنای زندگی در زندگی کارساز است.
تدوین مدل علی رابطۀ میان چشم انداز زمان آینده و خودتنظیمی بلندمدت با تحول شغلی؛ تلویحاتی درباره مشاوره روان شناختی با والدین دارای فرزند نوجوان
Publisher: name: دانشگاه کردستان
Year: 2020

description: یکی از نگرانی های شدید خانواده ها، انتخاب مسیر شغلی و هدایت تحصیلی فرزندان نوجوان است. پژوهشهای\nفراوانی به بررسی تحول شغلی در گروههای گوناگون پرداخته اند، ولی پژوهشی که به مدلیابی تحول شغلی در\nنوجوانان پرداخته باشد، تاکنون انجام نشده است. پژوهش حاضر با هدف ارائه مدل علی از رابطه میان چشم انداز\nزمان آینده و خودنظم جویی بلندمدت بر تحول شغلی با توجه به نقش واسطه ای نگرش به مدرسه در فرزندان \nنوجوان خانواده های شهر سنندج انجام شد. روش پژوهش، همبستگی از نوع مدلسازی معادلات ساختاری بود. از\nمیان جامعه دانش آموزان نوجوان مقطع متوسطه اول شهر سنندج تعداد 284 نفر به روش نمونه گیری تصادفی\nطبقه ای نسبی انتخاب و به ابزارهای خودگزارشی چشم انداز زمان آینده Shell & Husman) 2008 ،(خودنظم جویی \nنوجوانان Moilanen & Castillo, Dias( ,2014 ،)نسخه تجدیدنظر شده مقیاس ارزیابی نگرش به مدرسه\nSiegle & McCoach( 2003 )و نسخه استرالیایی سیاهۀ کوتاه تحول شغلی Patton & Creed( 2004 )پاسخ\nدادند. تحلیل دادهها با روش مدلسازی معادلات ساختاری به وسیله نرم افزار AMOS و SPSS انجام گرفت. یافته های\nاین پژوهش نشان داد که تحول شغلی با اطلاع از تراز چشم انداز زمان آینده و نگرش به مدرسه پیشبینی شد؛\nخودنظم جویی بر نگرش به مدرسه و تحول شغلی به طور مستقیم تأثیری نداشتند؛ نگرش به مدرسه تأثیر علی و\nمستقیمی بر تحول شغلی نداشت. همچنین چشم انداز زمان و خودنظم جویی با میانجیگری نگرش به مدرسه اثر \nغیرمستقیم بر تحول شغلی نداشت. یافته های این پژوهش مؤید تأثیر معنی دار چشمانداز زمان آینده بر تحول\n.شغلی فرزندان نوجوان خانواده های شهر سنندج است
Impact of smoking cessation in tobacco-related ocular neurodegenerative diseases using big data
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Glaucoma and age-related macular degeneration (AMD) are leading causes of blindness worldwide. Glaucoma is a condition that causes damage to the optic nerve. Without timely treatment, it worsens and you will lose peripheral vision. Glaucoma is more common and more severe among Black/African American individuals. Although high eye pressure is the main reason for optic nerve damage, many studies have shown that the blood supply to the eye is also involved in the development and worsening of glaucoma. Age-related macular degeneration is a condition that affects the macula, which is the part of your eye responsible for giving you clear central vision. With AMD, patients can lose central vision, making it difficult to see things clearly or do everyday tasks. Our prior research from TRDRP Pilot Award showed that the more someone smokes, the higher their chances of their glaucoma becoming worse. We discovered that stopping smoking can be helpful to halt glaucoma worsening in heavy smokers. We aim to understand how stopping smoking may lower the risk of eye diseases in diverse populations. To do this, we will use a lot of information from many people collected all over the country. We will confirm that taking care of your eyes and living a healthy lifestyle and stopping smoking can also help reduce the risk of developing glaucoma and AMD or worsening their effect on vision. This will be helpful for improving treatment recommendations to slow down glaucoma and AMD and ultimately prevent blindness.
The Role of 11β-HSD1 in E-Cigarette Smoke/Nicotine-induced Insulin Resistance
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking is associated with insulin resistance and type 2 diabetes (T2DM) and nicotine in cigarettes is an important component in smoking leading to blood glucose elevation and insulin resistance. E-cigarettes containing nicotine have gained popularity and may have potential diabetic risks of nicotine exposure. We found that both nicotine and electronic cigarettes led to stress hormone increases and disrupted glucose homeostasis and insulin sensitivity in normal mice which may lead to some of the detrimental hyperglycemia effects of smoking and electronic cigarettes. In our proposed study, we will use mice with or without nicotine including those via e-cigarettes to study multiple aspects that could be important to prevent and treat smoking and e-cigarette-related dysregulation of glucose and cortisol metabolism and control some of the risks and damage caused by smoking and electronic cigarettes in humans who use these products.
Exposure to e-cigarette in pregnancy programs a cardiac dysfunctional phenotype in offspring
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The prevalence of e-cigarette (e-cig) vaping has increased rapidly among youth and reproductive age of women. However, the potential health implications of vaping for pregnant women and their fetuses remain largely unknown. Moreover, it is unknown if and how this adverse effect on the unborn babies will persist into their postnatal and adulthood. To tackle this health issue, we propose this project. The rigor of this proposal is based on prior studies that e-cig products exert more pronounced toxic effects on embryonic cells compared to their adult counterparts, culminating in fetal growth restriction. This suggests a distinctive vulnerability of the developing fetus to e-cig-induced toxicity. Recently, we have developed a pregnant rat model of e-cig exposure. Our preliminary data unveiled a link between e-cig exposure and amplified ischemia/reperfusion (I/R)-induced heart injury and subsequent heart failure in adult offspring associated with alterations in cardiomyopathy and ischemia-sensitive markers. Building upon these pivotal findings, we hypothesize that prenatal e-cig exposure engenders modifications in fetal cardiac genes via an epigenetic mechanism, thus perpetuating into adulthood and instigating a dysfunctional cardiac phenotype. To test this hypothesis, we first will determine if fetal e-cig exposure causes heart dysfunction in adult offspring. Then, we aim to pinpoint cardiac dysfunctional markers specifically associated with e-cig exposure. Additionally, we will ascertain the epigenetic marker responsible for regulating cardiac fetal gene expression, specifically focusing on FTO/m6A RNA methylation. Finally, we will employ pharmacological and gene therapeutic interventions to gauge if restoring FTO-dependent m6A methylation ameliorates the e-cig-induced heart dysfunction phenotype. We expect that e-cig exposure induces FTO-dependent M6A hypermethylation, leading to alterations to cardiac ischemia-sensitive biomarkers and signaling networks within the developing heart, which persists into adulthood and develops a heart dysfunction phenotype. Our findings will provide novel evidence for the regulatory authority to warn the public that pregnant women and their unborn babies are vulnerable populations for e-cig exposure. Once the unborn babies are exposed to e-cig vaping in pregnancy, they are predisposed to cardiovascular disease in later life.
بررسی تأثیر تعارض زناشویی بر نگرانی های دوران بارداری: نقش میانجی بهزیستی روان شناختی
Publisher: name: دانشگاه کردستان
Year: 2020

description: درگیر شدن بانوان در تعارض و اختالفات زناشویی در دوران پر تنیدگی بارداری، دارای اثرات فراوانی است که میتوان با گسترش \nبهزیستی روانشناختی زنان باردار، وضعیت روانی آنها را در برابر تنشهای روانی پایدار کرد، ازاین روی هدف پژوهش حاضر بررسی \nتأثیر تعارض زناشویی بر نگرانیهای دوران بارداری با نقش میانجی گر بهزیستی روانشناختی بود. پژوهش حاضر توصیفی و از نوع\nهمبستگی بود. جامعه آماری همه زنان باردار 18-40 ساله مراجعه کننده به دفتر پزشک کارآزمودگان زنان و زایمان، بیمارستانها و \nمراکز بهداشت شهر مشهد در نیمه نخست سال 99-98 بود؛ نمونه آماری شمار 150 زن باردار است که به روش نمونه گیری در \nدسترس و بر پایه جدول مورگان انتخاب شده و موردبررسی قرار گرفتند. برای جمع آوری داده ها از پرسشنامه استاندارد تعارضات\nزناشویی بازنگری شده- 54 پرسشی )1388 ،)پرسشنامه نگرانیهای دوره بارداری )آلدرسی و لین، 2011 )و همچنین پرسشنامه\nبهزیستی روانشناختی )ریف، 2002 )استفاده شد. داده های جمع آوری شده، با به کارگیری مدلیابی معادلات ساختاری )SEM )به وسیله\nنرم افزار Spss23 و 8.8 srel Li تجزیه وتحلیل شد. نتایج نشان داد با توجه مقادیر ضریب مسیر و T ،تعارض زناشویی بر نگرانی\nدوران بارداری اثر مستقیم و معنادار دارد )68/0 و 48/7=T)؛ به عبارت دیگر هرچقدر تعارض زناشویی بالا رود نگرانی هم بالا میرود\n)01/0>P .)از سویی نتایج پژوهش نشان داد تعارض با بهزیستی روانشناختی اثر معکوس دارد )69/0 -و 82/7=-T)؛ یعنی هرچقدر\nتعارض بالا رود بهزیستی روانشناختی پایین میآید. با توجه به نتایج پژوهش میتوان گفت که تعارض زناشویی افزون بر اینکه می-\nتواند عامل خطری برای نگرانیهای دوران بارداری باشند، میتواند از راه بهزیستی روانشناختی اثر غیرمستقیمی بر تراز نگرانیهای \nدوران بارداری بگذارد
Genetic Mechanisms of Adolescent and Adult Nicotine Use
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: This project offers a new avenue of research in neuroscience by evaluating non-coding regions in the genome using novel tools in chemical biology to study mechanisms of addiction. Regulation of drug-induced behaviors via translated small open reading frames (smORFs) has been overlooked in addiction neuroscience. We have identified a 3' untranslated region (UTR) single nucleotide polymorphism (SNP) in the alpha(α)6 nicotinic acetylcholine receptor (nAChR) subunit (encoded by the CHRNA6 gene) that appears to regulate nicotine addiction. Our data show that this SNP leads to a two-fold increase in nicotine seeking and substance use in rodents and humans, respectively. The results are unique as studies in the field thus far have focused on SNPs in the coding regions of the genome. Our laboratory has engineered a CHRNA6 3' UTRC123G SNP mutant rat line that replicates the genetic variation in humans in order to functionally validate the mechanisms of enhanced nicotine use. We have introduced the entire human 3' UTR, with the 'C' to 'G' single nucleotide change in the 123 position in Sprague Dawley rats (α6CC and α6GG-carriers), thereby enhancing the animal model's translational significance to humans. We will test the hypothesis that the α6 3' UTR SNP regulates nicotine-induced effects on the brain and behavior in an age-dependent manner via changes in gene or protein expression in ventral tegmental area (VTA)-Nucleus Accumbens (NAc) brain reward neurons. By providing a new conceptual framework for how 3' UTR genetic human polymorphisms regulate drug-induced brain effects, our approaches could uncover new proteins in addiction. Our studies may significantly influence the field, as we aim to discover targeted gene or other 3' UTR regulatory mechanisms mediating sex- and genotype-dependent effects in addiction. The mechanisms found to regulate age-, genotype- and sex-dependent effects could then be targeted. Such work on the α6 3' UTR SNP could lead to future high throughput screening strategies with the ability to translate genomic sequence into drug therapeutics for nicotine use cessation. Overall, our studies have potential impacts in nAChR biology, addiction neuroscience, and drug discovery. This is significant given the exponential increase in adolescent electronic nicotine and poly-drug use, necessitating improved prevention / intervention strategies.
Additional file 1 of Serratia marcescens in the intestine of housefly larvae inhibits host growth by interfering with gut microbiota
Creators: name: Li, Ying
name: Wang, Shumin
name: Zhang, Kexin
name: Yin, Yansong
name: Zhang, Xinyu
name: Zhang, Qian
name: Kong, Xinxin
name: Tang, Luyao
name: Zhang, Ruiling
name: Zhang, Zhong
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 1: Table S1. Name, location, year of isolation, and morphology of the phage used in this study.
sj-pdf-1-jit-10.1177_1528083720923773 - Supplemental material for Branched nanofibers with tiny diameters for air filtration via one-step electrospinning
Creators: name: Zaarour, Bilal
name: Tina, Hussen
name: Zhu, Lei
name: Jin, XiangYu
Publisher: name: SAGE Journals
Year: 2020
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-jit-10.1177_1528083720923773 for Branched nanofibers with tiny diameters for air filtration via one-step electrospinning by Bilal Zaarour, Hussen Tina, Lei Zhu and XiangYu Jin in Journal of Industrial Textiles
sj-pdf-2-hol-10.1177_0959683620919985 - Supplemental material for The lost paradise of snails: Transformation of the middle-Holocene forest ecosystems in Bohemia, Czech Republic, as revealed by declining land snail diversity
Creators: name: Juřičková, Lucie
name: Šída, Petr
name: Horáčková, Jitka
name: Vojen Ložek
name: Pokorný, Petr
Publisher: name: SAGE Journals
Year: 2020
Subjects: Geography
History

description: Supplemental material, sj-pdf-2-hol-10.1177_0959683620919985 for The lost paradise of snails: Transformation of the middle-Holocene forest ecosystems in Bohemia, Czech Republic, as revealed by declining land snail diversity by Lucie Juřičková, Petr Šída, Jitka Horáčková, Vojen Ložek and Petr Pokorný in The Holocene
E-commerce surveillance to inform local tobacco policy and enforcement
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: We are working on improving the way we check that online retailers of tobacco follow local laws. We have started a program that watches how tobacco products are sold online and we've tested it with stores that sell vaping products to consumers in San Diego. We're looking to upgrade this program so it can be used across the whole state. Our plan is to achieve our goal by focusing on the following key steps. Aim 1. Collect and refine a list of vape shops throughout California. Aim 2. Conduct e-commerce marketing surveillance of brick-and-click vape shops. Aim 3. Make flavored vaping product purchase attempts from brick-and-click vape shops. Aim 4. Create a restricted-access website that disseminates data to local lead agencies. This research will provide data and resources that can be used to understand how tobacco retailers utilize e-commerce to sell their products in California. We will disseminate the data via our website and also host trainings on how to use our website and the methods we use to monitor policy compliance.
Additional file 6 of Serratia marcescens in the intestine of housefly larvae inhibits host growth by interfering with gut microbiota
Creators: name: Li, Ying
name: Wang, Shumin
name: Zhang, Kexin
name: Yin, Yansong
name: Zhang, Xinyu
name: Zhang, Qian
name: Kong, Xinxin
name: Tang, Luyao
name: Zhang, Ruiling
name: Zhang, Zhong
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 6: Table S5. Topological properties of bacterial co-occurrence networks associated with the different treatments.
Technology-Assisted Motivational Interviewing Coach for Smoking Cessation: The TAMI Coach
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Although rates of smoking have decreased dramatically, tobacco still accounts for 480,000 deaths per year and over 16 million adults suffer from smoking-related illnesses. This burden is disproportionately felt by underrepresented minorities, people with lower education and income, and individuals with behavioral health conditions. Motivational interviewing (MI) successfully enhances patients’ motivation to quit smoking by evoking their ambivalence about quitting. Although MI works, it can be time intensive, require substantial expertise, and patients still need tailored referrals to smoking cessation programs that fit their needs, social circumstances, and resources. Using the latest in artificial intelligence (AI), digital assistants that assess readiness, delivery quality MI, and make tailored referrals to cessation treatment programs could provide an effective and efficient way to prevent smoking-related illnesses and death. This proposal evaluates a pilot-tested chatbot that delivers an MI-based intervention to assess and promote readiness to quit then creates a detailed, tailored quit plan including education about quit tools. Our pilot study showed that our research protocol was acceptable and verified that even smokers not interested in quitting were willing to use the chatbot. Many smokers (in both the intervention and control groups) were willing to make a quit attempt but the pilot was not powered to test any hypotheses. The chatbot architecture and machine learning models functioned well enough to deliver quality MI and successfully tailor referrals. We propose to first improve the chatbot functionality by incorporating recent advances in AI language models (e.g. ChatGPT-4), adding interventions to build patient confidence in their cessation plan, provide great support and follow-up both before and after a quit-date, link patients with a prescriber if pharmacotherapy is needed, and to improve the quit plan tailoring process by expanding the assessment of social needs. This optimized chatbot will then by evaluated in a randomized, controlled trial comparing smokers who use the chatbot with those in usual care. Our primary outcome will be biochemically-verified smoking cessation at 6 months and we will also be assessing other changes such as improved motivation or readiness to quit, self-confidence in quitting, and use of other nicotine products.
Plocaederus plicatus
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Plocaederus
Plocaederus plicatus

description: 18. Plocaederus plicatus (Olivier, 1790)
 Cerambyx plicatus Olivier, 1790: 299. Material examinado: Caxias (Reserva Ecológica Inhamum, Povoado Coités), fêmea, 03-05.X.2005, F. Limeira-de-Oliveira col., armadilha luminosa; macho, 04-06.VIII.2005, F. Limeira-de-Oliveira col., armadilha luminosa.
 Sphallotrichina
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 234, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
Supplemental Material, Appendix_A - The ebb and flow of sexual well-being: The contributions of basic psychological needs and autonomous and controlled sexual motivation to daily variations in sexual well-being
Creators: name: Gravel, Emilie E.
name: Reissing, Elke D.
name: Pelletier, Luc G.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, Appendix_A for The ebb and flow of sexual well-being: The contributions of basic psychological needs and autonomous and controlled sexual motivation to daily variations in sexual well-being by Emilie E. Gravel, Elke D. Reissing and Luc G. Pelletier in Journal of Social and Personal Relationships
The impact of tobacco smoke exposure on alveolar epithelial cells in idiopathic pulmonary fibrosis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by excessive scar tissue formation (fibrosis), which leads to tissue destruction, difficulty breathing and ultimately death. IPF patients survive for only about 3-5 years. To date, the exact cause of the IPF is unclear but cigarette smoking (CS) is believed is one of the risks. CS causes the damage of alveolar epithelial cell (cells that line air sac), which produce the scar-promoting molecule leading to IPF. One of the damages the CS induced is endoplasmic reticulum (ER) (a place where protein is produced) stress, which is known to play pivotal roles in the development of IPF. C/EBP homologous protein (CHOP) is a protein that induce cell death when cells response to ER stress. We have reported that ER stress induced by loss of a protein called GRP78 in alveolar epithelial cell can lead to lung fibrosis in a mouse model called Grp78 knockout (KO) mice. Our preliminary data in Grp78/Chop double KO mice further demonstrated that CHOP is a key factor involved in the development of lung fibrosis. We also observed CS exposure increased CHOP expression and lung fibrosis in the slices of Grp78 KO and IPF lung culture. These data lead us to study a hypothesize that CS worsen the damage of alveolar epithelial cell and lung fibrosis through the induction of much severer ER stress, with a specific emphasis on CHOP. To validate this hypothesis, we will: 1) Explore whether CS worsen AT2 damage and lung fibrosis through CHOP using AT2 cells and lungs from Grp78 KO and Grp78/CHOP double KO mice, as well as from IPF patients and normal donors who are smokers and non-smokers. 2) Identify new factors contributing to CS-induced AEC damage and lung fibrosis using techniques such as RNA sequencing and ATAC-Sequencing on AT2 cells from IPF patients and normal donors who are smokers and non-smokers.
Additional file 2 of Serratia marcescens in the intestine of housefly larvae inhibits host growth by interfering with gut microbiota
Creators: name: Li, Ying
name: Wang, Shumin
name: Zhang, Kexin
name: Yin, Yansong
name: Zhang, Xinyu
name: Zhang, Qian
name: Kong, Xinxin
name: Tang, Luyao
name: Zhang, Ruiling
name: Zhang, Zhong
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 2: Table S2. Infectivity range of phage SMP against gut bacteria of housefly larva. Phages were spotted onto the lawns of each bacteria and incubated overnight at 37 °C. Zones of clearing indicated infectivity.= lysis;= no lysis.
sj-pdf-1-epb-10.1177_2399808320919771 - Supplemental material for Validating activity, time, and space diversity as essential components of urban vitality
Creators: name: Chaogui Kang
name: Dongwan Fan
name: Hongzan Jiao
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Geography
subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-pdf-1-epb-10.1177_2399808320919771 for Validating activity, time, and space diversity as essential components of urban vitality by Chaogui Kang, Dongwan Fan and Hongzan Jiao in EPB: Urban Analytics and City Science
Role of Perm1 in cardiac dysfunction - induced by cigarette smoke exposure
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking is a major risk factor for cardiovascular diseases. It increases the risk of atherosclerosis which causes plaque to build up in artery walls, including those which supply heart muscle. When plaque narrows vessels in the heart, it can restrict blood flow to the heart and lead to angina (chest pain) when the oxygen requirements of the heart outstrip that supplied by the blood vessels. In addition, when a plaque ruptures, it can trigger a blood clot to be formed, leading to total occlusion of a coronary (heart) vessel, causing a heart attack, known as a myocardial infarction (MI). With MI, irreversible death of heart muscle cells occurs, and also heart rhythm can be so disturbed that the heart cannot pump adequately, often leading to sudden and immediate death. Therefore, finding new ways to protect the heart from decreased blood flow will help patients suffering from tobacco-related coronary heart disease. Mitochondria, which are small organelles inside heart muscle cells, are responsible for energy production that is essential for normal heart function. When mitochondrial function is disturbed, it can exacerbate heart muscle cell death. Emerging evidence shows that reduced blood supply (ischemia) can cause mitochondrial dysfunction, leading to heart muscle cell death and heart dysfunction. In the proposed project, we will study the role of Perm1, a novel mitochondrial regulator, in ischemic injury using genetically engineered mouse models. Our hypothesis is that the Perm1 protein protects heart muscle cells from the damage they can incur with decreased blood supply. By using gene manipulations, we have made mice with increased and decreased Perm1 expression in the heart. We will use these mice to study the function of Perm1 in the heart. In addition, we will also study the potential mechanism(s) by which Perm1 protects the heart from the damage caused by a decreased blood supply. Long range, we hope our research will lead to identification of potential therapeutic target(s) for treating the consequences of tobacco or tobacco-related product-induced coronary artery disease and resultant heart disease.
Effect of aerosolized tobacco products on S. mutans-S. sanguinis-C. albicans caries pathogenicity
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The use of vaping or e-cigarettes among teenagers and young adults is a growing health crisis with significant impacts on overall and oral health. Nicotine use is strongly associated with dental caries, an oral disease prevalent in this age group. The cooperative relationship between important dental caries-causing bacteria (Streptococcus mutans, Sm) and fungus (Candida albicans, Ca) is an important factor in dental caries development. On the other hand, beneficial bacteria like Streptococcus sanguinis (Ss) can prevent Sm growth, attach to Ca, and reduce Ca growth. However, their interactions in caries development and the influence of Ss on the Sm-Ca relationship are unclear. Recent studies have shown that pure nicotine (N) can stimulate the cooperative relationship between Sm and Ca and increase the growth of Sm when grown together with Ss. Although there are indications that N has an enhanced effect on causing dental caries, most research studies have focused on N instead of nicotine vape aerosols (N-VA) produced by e-cigarettes. Additionally, very limited studies have been conducted on the effect of N-VA on Sm, Ss, and Ca. Our previous study and supporting data for this study showed that at the same nicotine content, the response of Sm and Ca to N was different from N-VA, which led us to hypothesize that nicotine vape aerosol affects the dynamic relationship between Sm, Ca, and Ss and potentially impacts dental caries disease differently than pure nicotine. In Aim 1, we will evaluate the effect of N-VA on the Sm-Ss-Ca relationship compared to N using a well-characterized bacteria line to evaluate co-adhesion, biofilm formation, sugar-based substances produced by bacteria, acid production, and transcriptome (gene expression). In Aim 2, we will study the effect of N-VA on the impact of Ss on the Sm-Ca relationship and dental caries-causing activity. Findings will contribute to the understanding of the effect of N-VA on the interactions between Sm, Ss, and Ca compared to N and will be critical for understanding the role of these microorganisms in the reported significantly elevated caries prevalence in nicotine vapers, especially in adolescents and young adults.
Supplemental Material, sj-pdf-1-ahp-10.1177_0890117120923948 - Neighborhood Poverty Histories and Physical Activity Among Children: Findings From the Geographic Research on Wellbeing (GROW) Study
Creators: name: Yeonwoo Kim
name: Cubbin, Catherine
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-1-ahp-10.1177_0890117120923948 for Neighborhood Poverty Histories and Physical Activity Among Children: Findings From the Geographic Research on Wellbeing (GROW) Study by Yeonwoo Kim and Catherine Cubbin in American Journal of Health Promotion
Cigarette Smoking-induced miR-483 Transversion Aggravates Pulmonary Hypertension
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking (CS) is a leading cause of lung diseases, including pulmonary hypertension (PH) which refers to elevation of blood pressure in the pulmonary arteries and stress in the right heart. Pulmonary arteries, covered by a thin layer of endothelial cells, carry blood from the heart to the lung for oxygen. New evidence indicates that endothelial dysfunction in pulmonary arteries contributes to PH. MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression. We and others reported that miR-483 promotes a healthy pulmonary endothelium, and decreased levels of miR-483 lead to endothelial dysfunction. In relation to CS-induced lung injury, miR-483 can convert to its oxidized form, namely, oxidized miR-483 under harmful conditions such as CS. Consequently, this change aggravates PH. In this study, we will use cultured lung endothelial cells and animal CS models to investigate the mechanism by which CS induces miR-483 oxidation. Moreover, we will study whether small RNA blocks will alleviate the CS-induced PH. Results from these proposed experiments will help to collect pilot data for future research on CS, miR-483, and PH.
title: The Effect of Multiple Pulses on Bacteria
Creators: name: Aly, Ramy El-Sayed
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2001

description: Pulsed electric fields are widely used for bacterial decontamination of water and liquid food [I]. Depending on pulse amplitude and duration, a certain percentage of the bacteria suffer irreversible damage and, consequently, cell death. We have explored the effect of microsecond pulses of 13 kV/cm and 15 kV/cm electric field amplitude on the viability of Escherlchia coli. The pulse duration was varied from 4 μs to 32 μs, and the pulse number of 4 μs pulses from one to eight, Finally, the effect of separation between pulses was studied. The pulses were generated by means of a generator where IGBTs were used as closing and opening switches. The maximum voltage was 1.5 kV at a maximum current of 160 A. The load was a cuvette with plane I cm aluminum electrodes, 1mm apart and filled with a solution (LB Broth) that contained E. coli bacteria at a concentration of approximately 3x105 cells/ml. The viability of the E. coli after electric field application was measured by using manual counting for E coli colonies in cultured agars. The bacterial decontamination rate was found to increase with pulse duration up to g Its and then to decrease again.

This maximum decontamination rate is assumed to be related to dipole formation in the rod-shaped bacteria. It causes a reorientation of the E. coli into the direction of the electric field and consequently a higher possibility for irreversible damage. The experimental results with varying temporal separation between two consequence pulses show that independent of field amplitude (in the relatively narrow range of 13 kV/cm to 15 kV/cm), the decontamination rate decreases logarithmically with increasing separation. This effect is assumed to be due to the randomization of the directions of the axis of rod-shaped bacteria in the broth after exposed to an electric pulse.
Additional file 7 of Serratia marcescens in the intestine of housefly larvae inhibits host growth by interfering with gut microbiota
Creators: name: Li, Ying
name: Wang, Shumin
name: Zhang, Kexin
name: Yin, Yansong
name: Zhang, Xinyu
name: Zhang, Qian
name: Kong, Xinxin
name: Tang, Luyao
name: Zhang, Ruiling
name: Zhang, Zhong
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 7: Figure S2. Phage targeted reduction of S. marcescens in wheat bran. Ct, SMPa, and SMPb represent wheat bran samples treated with sterile water and sterile water containing 107 and 1011 PFU/mL phage, respectively. Values are the means ± standard deviations from triplicates of each treatment. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. n.s., no significance.
Contingency Management for Veteran Smokers Undergoing Major Elective Surgery
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: We propose to design and test a smoking cessation mobile contingency management (CM) intervention for Veterans undergoing major elective surgery. Smoking is the most important risk factor for adverse outcomes during and after surgery. Rates of smoking at the time of surgery are high, 22.3-43.0%, particularly among Veterans and people with health disparities. Smoking at the time of surgery is associated with complications, reoperations, and mortality. Despite these risks, smoking cessation treatment is often not integrated into surgical care. CM promotes smoking cessation by providing financial rewards for quitting. CM for smoking cessation has been shown to improve quit rates, but studies reveal that CM is most likely to work when tailored for the patient population. CM for smoking cessation has never been conducted before and after major surgery. Advances in mobile technology allow for remote (mobile) monitoring of carbon monoxide (CO) to confirm smoking abstinence for outpatients receiving CM. We will develop the first-of-its-kind mobile CM smoking cessation protocol for Veterans undergoing major elective surgery. We will consult with a Community Advisory Panel of Veteran patient advocates and content experts on CM, surgery, and VA healthcare policy about methods for CM delivery. The panel will advise on timing and approach of CM for VA surgery patients. In a 5-week pilot randomized controlled trial (RCT), we will randomly assign 36 Veteran smokers undergoing major elective surgery to receive 5 weeks of CM with mobile CO monitoring or treatment as usual (TAU), referral to a VA smoking cessation clinic and quitline. Both groups will receive smoking cessation medication. We will measure feasibility of smoking cessation CM at the time of surgery by tracking recruitment, engagement, and retention in the study. We will also assess the effect of CM compared to TAU on smoking cessation outcomes, including quit attempts; cigarettes per day; nicotine dependence; and quit rates. This innovative study is the first to deliver CM before and after major surgery, and targets a high-priority California tobacco population, military Veterans. Results will inform treatment for other high-risk surgical populations. Findings will be used to apply for VA Merit funding to conduct an RCT examining the effect of CM on smoking outcomes among Veteran smokers undergoing surgery.
Dissecting Genotype-driven Metastatic Ability
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the leading cause of cancer-related deaths in the world, and the development of tissue- destructive metastasis is responsible for the majority of these deaths. Lung adenocarcinoma is the most common type of lung cancer and is heavy associated with smoking. Lung adenocarcinoma can metastasize to many different organs, including the liver, brain, and back to the lung. Many different genes are mutated in lung adenocarcinoma in different patients. The collection of genes that are mutated in a tumor is called the tumor “genotype". Despite this diversity of genes mutated in lung adenocarcinoma the contribution of the tumor genotype to metastatic ability remains largely unexplored. To determine the extent that genotype drives different aspect of metastasis, we will integrate cutting-edge multiplexed CRISPR/Cas9 somatic genome editing and tumor barcoding with in vivo metastases assays. This will uncover which genotypes drive metastatic ability across different organ sites. Understanding how tumor genotype influences metastatic ability could have prognostic implications and ultimately uncover targetable pro-metastatic pathways. Primary tumors often create an immunosuppressive environment, however when cancers try to metastasize to other organs the cancer cells are re-exposed to immune detection. Thus, metastatic cancer cells likely possess or acquire specific adaptations. While some tumor genotypes have been suggested to reduce anti-cancer immune responses, understanding the extent to which genotype contributes to immune evasion has implication for immunotherapy treatment of lung cancer patients. By quantifying the impact of genotype on the ability of metastases to seed and grow at different sites, we will uncover genotypes that enable lung cancer cells to evade immune destruction at some of all distant sites. For the past decade my laboratory has been dedicated to studying lung cancer. We have investigated lung cancer metastasis and developed new methods to better uncover how genotype impact different clinically relevant aspects of lung cancer. We are excited about the proposed studies because they are unique from what others in the field are doing and have the potential to establish a new paradigm of how lung cancer gains that ability to spread throughout the body.
2019_performance_feedback_JOM_submission_online_appendics_R2_final_version3 – Supplemental material for Performance Feedback Persistence: Comparative Effects of Historical Versus Peer Performance Feedback on Innovative Search
Creators: name: Ye, Yang
name: Yu, Wei
name: Nason, Robert
Publisher: name: SAGE Journals
Year: 2020
Subjects: Organisation and Management Theory

description: Supplemental material, 2019_performance_feedback_JOM_submission_online_appendics_R2_final_version3 for Performance Feedback Persistence: Comparative Effects of Historical Versus Peer Performance Feedback on Innovative Search by Yang Ye, Wei Yu and Robert Nason in Journal of Management