cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Studying breast cancer initiation in single cell resolution
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer is one of the most prevalent forms of cancer in women worldwide. Despite recent advances in understanding the genetic mutations driving breast cancerogenesis, prognosis still remains poor especially due to late diagnosis and subsequent high mortality from metastatic tumor formation. One major scientific roadblock is that most of our scientific knowledge in cancer research is based on averaged ensemble analyses, although heterogeneity within the cell population is a striking feature of many tumors and plays a critical role in driving disease progression and therapy resistance. BRCA1+ carriers have a high risk of developing triple negative basal-type breast cancer, and thus commonly undergo prophylactic radical mastectomy. Studying these tissue samples from BRCA1+ carriers at pre-neoplastic and neoplastic stages offers a unique opportunity to study cancer initiation and progression in a primary human and clinically relevant setting. We hypothesize BRCA1-driven breast cancer leads to the disruption of the normal breast epithelial cell hierarchy and distinct systems-level changes in gene expression signatures not only within the subset of transformed tumor initiating cells, but also within other epithelial cell populations and non-epithelial microenvironmental components. We have established an interdisciplinary research approach utilizing comprehensive single cell RNAseq in combination with cutting edge bioinformatics pipelines to study tumor heterogeneity and to build a cell atlas delineating cancer initiation and progression in single cell resolution. By creating a cell atlas of the human breast in single cell resolution, and interrogating how the system goes awry during tumor initiation, we will identify disease promoting subpopulations, discover novel biomarkers and testable gene signatures to improve cancer early detection, and reveal novel therapeutic targets to prevent breast cancer from progressing into a life threatening condition. Ultimately, this project has the potential to revolutionize cancer genomics and precision medicine by introducing single cell genomics to translational breast cancer research, and thereby providing a first impetus towards the generation of a Single Cell Cancer Genome Atlas (SCCGA).
Prognosis of prostate cancer using multi-omics datasets
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Effective approaches are urgently needed to distinguish aggressive prostate tumors from the indolent forms. The currently used commercial tests, including Prolaris®, Decipher® and OncotypeDX GPS®, provide choices of treatment based on patients’ individual disease states. However, the predictive abilities for these tests need to be increased to meet clinical need for resolving overtreatment which continues to be a health issue in prostate cancer management owing to the negative and unnecessary side effects. In these commercial tests, only a few dozens of genes are used for the perdition of disease outcomes. We have demonstrated that inclusion of many minor predictors, e.g., thousands of DNA markers, in genomic prediction models can substantially improve the trait predictability in crops. Therefore, we hypothesize (1) A prognostic model using whole-transcriptome metrics as predictors will outperform the commonly employed models which only consider major gene expression. (2) The prognostic power will be further increased if other omics predictors are also factored into the model. We will test these two hypotheses by leveraging The Cancer Genome Atlas (TCGA) data and two validation datasets which are publicly available. The best linear unbiased prediction (BLUP) methodology will be applied to the TCGA data to develop an optimal prediction model based on the selected multi-omic variables. The performance of the new multi-omics prognostic model will be verified by rigorous cross validation and by the validation datasets. Possible combination of clinical predictors with the selected multi-omics predictors will be investigated to further increase the predictability of the prognostic model. All the proposed analysis may be conducted on high-performance personal computers in the PI’s lab. The high-performance computing facility at UC Riverside, including the main compute cluster with ~3600 CPU cores, 30TB of total RAM and the latest Infiniband interconnect, will be available for this project. The successful completion of the project will (1) prove the concept that prediction models using multi-omics datasets provide improved prognostic power in prostate cancer, and (2) produce a prognostic model that may be translated to clinical management of prostate cancer.
Mapping translocations induced by defective R loop removal
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Recurrent DNA translocations characterize blood cell cancers, and are frequently products of aberrant repair of programmed DNA double-strand breaks (DSBs). Defining the precise molecular mechanisms governing DSB generation and repair is critical to revealing how lymphoid cancers arise. The majority of cancers involving antibody-producing B cells arise during class switch recombination (CSR), a programmed DNA repair event at the immunoglobulin heavy chain (IgH) locus. CSR is initiated by DSBs generated by the enzyme AID, whose recruitment to IgH requires transcription. AID-dependent DSB formation strongly correlates with the appearance of R loops—three-stranded nucleotide structures where newly transcribed RNA re-anneals to template DNA. Though R loops were observed at the IgH locus over 20 years ago, their role in CSR remains undefined. To investigate the role R loops play in CSR, we generated mice deficient for two enzymes promoting R loop dissolution, the helicase Senataxin (SETX-/-) and the nuclease RNase H2 (RNH2Bf/f). We find that SETX-/- RNH2Bf/f B cells have increased R loop formation. Over 10% of double-deficient cells accumulate unrepaired DNA breaks and translocations at IgH, while single mutants show modest IgH instability. All 4 genotypes are proficient for CSR, thus DSB repair is largely intact. These results show that Setx and RNase H2 act independently to promote genome stability and suppress aberrant DNA repair during CSR. To test our hypothesis that the presence or absence of R loops affects repair pathway choice, we propose to map genomic loci translocated to the IgH locus using High-Throughput Genome-wide Translocation Sequencing (HTGTS) in WT, SETX-/-, RNH2Bf/f, and SETX-/- RNH2Bf/f B cells undergoing CSR. Importantly, we will use long-read (150-300 bp) paired-end sequencing to capture DNA from IgH and partner loci and sequence overlapping the junction site. HTGTS maps will define the location and frequency of IgH translocation partners found in Setx, RNase H2 and double-deficient cells. Further, we will use translocation junction sequences to define the extent of homology found at the breakpoints, and infer the DSB repair pathways promoting translocation formation. Defining the precise mechanisms underlying R loop-associated translocation formation will provide novel molecular targets for cancer prevention and therapeutic intervention.
Additional file 1: of Linking household surveys and health facility assessments to estimate intervention coverage for the Lives Saved Tool (LiST)
Creators: name: Mufaro Kanyangarara
name: Chou, Victoria
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Table: Indicator definitions. (DOCX 17Â kb)
Catantops erubescens
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Catantops
Catantops erubescens

description: 1. Catantops erubescens (Walker, 1870)
This species has a particular range: Azad Jammu & Kashmir and Tamil Nadu (India) (Cigliano et al. 2024). Due to its limited range, conservation measures may be necessary; otherwise, its diversity may disappear from these regions as well. Earlier, this species was reported from North Bengal, Arunachal Pradesh, West Bengal, and Azad Jammu and Kashmir (Kirby 1914; Shishodia & Chandra 2010; Naizer et al. 2014).
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 34, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Polydactylus opercularis
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Polynemidae
Polydactylus
Polydactylus opercularis

description: Polydactylus opercularis (Gill 1863). Yellow Bobo; Bobo Amarillo, Barbudo de Nueve Barbas
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from southern California, USA, to Chile; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER and PN (Pacific); 0–8 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Villa (1982: 211; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Allen (2015: 1403; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 42, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Paraconophyma kashmirica Mistshenko 1950
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Paraconophyma
Paraconophyma kashmirica

description: 2. Paraconophyma kashmirica Mistshenko 1950
This species is reported from Kasmir and is considered a high-altitude species (Bey-Bienko & Mistshenko 1951; Mahmood et al. 2002; Gupta & Chandra 2018). It is unlikely to occur at low sea level (Wagan & Sultana 2013).
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 34, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
title: Trastornos no motores y su sustrato neuro-anatómico en la enfermedad de Parkinson
title: Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease
titleType: AlternativeTitle
Creators: name: López Argüelles, Julio
name: Sosa Águila, Leydi María
Publisher: name: Zenodo
Year: 2025
Subjects: enfermedad de parkinson; sistema nervioso central; estudios clínicos

description: La enfermedad de Parkinson se mantiene como el segundo trastorno degenerativo del sistema nervioso central después del Alzheimer. Aunque inicialmente fue descrito como un padecimiento con trastorno motor exclusivo, se ha demostrado que los trastornos no motores del Parkinson, son una parte importante del cuadro clínico. Entre ellos se incluyen todos aquellos desórdenes que no son síntomas motores: trastornos neuropsiquiátricos conductuales (demencia, depresión, ansiedad, psicosis); alteración autonómica (hipotensión postural, desórdenes gastrointestinales y genitourinarios, diaforesis); trastornos del sueño; síntomas sensitivo-motores (fatiga, síndrome de piernas inquietas). Se cree que la degeneración de los sistemas celulares no dopaminérgicos (noradrenérgicos, serotoninérgicos y colinérgicos) son la base del desarrollo de la mayoría de los trastornos no motores. Son necesarios nuevos estudios para poder esclarecer las bases fisiopatológicas de la enfermedad de Parkinson que permitan establecer futuras estrategias terapéuticas para el seguimiento de los pacientes con estos padecimientos.
Titanium sands of southern New Jersey
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1959

description: The expanding demand for ilmenite for use in the manufacture of titanium pigments, the knowledge that much of this raw material comes from distant points and therefore has to include a heavy freight charge in the price of the delivered product, and the further knowledge that ilmenite occurs both in the crystalline rocks of northern New Jersey and also in some of the Triassic igneous rocks, were considerations which led to a search for ilmenite-bearing sands in southern New Jersey. The report also discusses:  geography, geology, criteria used, mineralogy, as well as the results of scientific analyses.
Bath, city under seige
Creators: name: Polihros, Susanna
Publisher: name: No Publisher Supplied
Year: 2014

description: This thesis examines current historic preservation and conservation efforts  for Bath, England’s only complete UNESCO World Heritage city, where urban  and commercial development remain a controversial threat. This is best  represented by the opposing views of the Bath Preservation Trust and the Bath &  North East Somerset Council. While the Trust stands as a supporter of saving  Georgian Bath, the Council continues to sacrifice precious greenbelt areas and  historic buildings for the purpose of attracting tourists and prospective residents.  Both organizations are extensively examined within the course of this  thesis with the intention of better comprehending the future of Bath. Although no  definite answer can be reached at this point in time, examining social and  political issues in this city demonstrates that there is a serious need for legal  intervention to prevent further destruction to a past way of life so that the modern  world can emerge.  To compile such an argument, I begin with a historical overview of the  city’s culture and architecture in relationship to the growing presence of tourism,  derived from official Bath and UNESCO websites. This establishes a framework  for the rest of my argument. I then discuss the unsettled issue of fracking and its  impact upon Bath’s architecture, namely the successfully restored Roman Baths.  This is juxtaposed to the loss of Bath’s architectural heritage through the creation  of SouthGate, a modern shopping mall in the heart of the city. Although  SouthGate initially threatened Bath’s UNESCO status, completion of the recent  Western Riverside Development will ultimately determine Bath’s final UNESCO  standing.  Much like the opinions of other authors, I too believe that the city needs to  strive for a balance between the past and the modern world to remain  functioning. However, this issue is compromised by the insufficient existence and  creation of laws meant to monitor activity by developers. Strong government  involvement, in addition to public protest and petitions, are needed to discourage  the Council from working alongside with developers to erase Bath’s past in the  interests of profit. This is exemplified through Beckford’s Tower and the  Gasholder. Both buildings serve as a contrast, with the former’s safeguarding  and the latter’s destruction, for the completion of the Western Riverside. The  feasible goal is attaining a balance between the heritage of a land and modern  day pragmatism without diminishing Bath as a living masterpiece by its creators.
Eutrigaster (Graffiona) montana Csuzdi & Zicsi 1991
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Eutrigaster
Eutrigaster montana

description: Eutrigaster (Graffiona) montana Csuzdi & Zicsi, 1991
Eutrigaster (Graffia) montana Csuzdi & Zicsi, 1991 Acta Zool. Hung. 37 (3–4): 185.
Eutrigaster (Graffia) montana: Csuzdi 1997 Opusc. Zool. (Budapest) 29-30: 45.
Eutrigaster (Graffiona) montana: Csuzdi 2014 Zootaxa: 150.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Polydactylus virginicus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Polynemidae
Polydactylus
Polydactylus virginicus

description: Polydactylus virginicus (Linnaeus 1758) (Fig. 8B). Barbu, Barbu Threadfin; Barbudo Barbú
Vouchers: Not available. Distribution: Western Atlantic Ocean; from New Jersey, USA, to Salvador, Brazil, excluding the Gulf of Mexico; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) WK and BF (Atlantic); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2015), population trend unknown. Literature: Villa (1982: 211; detailed description, including illustrations and an identification key, and information on distribution and ecology), Robertson & Allen (2015: 3829; detailed description, including illustrations, and information on distribution, with a map, and ecology), van den Berghe (2015: 45, as Polydactylus oligodon (Günther 1860) —misidentification; listed, including an illustration and information on distribution and ecology) and Angulo (2021: 42; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 42, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Modeling and control of proton exchange membrane and solid oxide fuel cells and solar cells
Creators: name: Park, Gun-Hyung
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation addresses the modeling and control problems of proton exchange membrane fuel cells (PEMFCs) and solid oxide fuel cells (SOFCs), and solar cells in which the Cuk converter used for maximum power point tracking. Sliding mode control techniques are developed to keep pressures of oxygen and hydrogen at the desired values in PEMFCs and SOFCs and a jump parameter linear system controller is designed for the Cuk converter.    For PEMFCs, the sliding mode control strategy is applied to both the 5th-order linearized model and the corresponding nonlinear model. The well-known material balance model is linearized, and it is shown that it is asymptotically stable, controllable, and observable at the unique equilibrium point. Then the sliding surfaces for anode and cathode are designed, and sliding mode controllers are proposed for each sliding surface to make hydrogen and oxygen pressures close to each other and at the desired values despite of the abrupt fuel cell current changes. The sliding mode controller for nonlinear PEMFCs model is also designed. For SOFCs model, the sliding surface for anode side is the same as that for PEMFCs, but that of the cathode side is designed to force oxygen pressure to follow hydrogen pressure. The proposed controllers for fuel cells keep very precisely pressures of hydrogen and oxygen at the require values. Especially, the sliding mode controller for SOFCs makes the pressure difference between hydrogen and oxygen very small in both the transient mode and at steady state.    For the jump parameter linear system control technique applied to the Cuk converter, with an accelerated algorithm, we have found the optimal values by changing the duty cycle and applied this technique with the integral action to keep the output voltage of the Cuk converter at the desired value despite of a constant disturbance on the input. The proposed  controller with integral action outperforms the averaged converter system that has been most commonly used for DC-DC converter model.
Sling-shot buckling in stacked piezoelectric structures
Creators: name: Pavlou, Michael
Publisher: name: No Publisher Supplied
Year: 2014

description: A stacked structure consisting of two beam-plates, each being a different piezoelectric material, subject to a uniformly increasing electric field is analyzed.  One beam-plate is perfectly adhered over the central portion of the other.  We consider the limiting boundary conditions for the bottom layer, the baseplate: clamped-fixed and hinged-fixed boundaries.  A quasi-static analysis is performed, in which a geometrically nonlinear strain-displacement relation is incorporated to account for infinitesimal strain, while allowing for moderate rotation of the structure.  The strain energy of the stacked structure is formulated, and the governing equations, constitutive relations, and boundary and matching conditions are derived self-consistently after invoking the Theorem of Stationary Potential Energy.  Stability is assessed through evaluation of the second variation of the PE under perturbation.  A closed form analytical solution is obtained, and numerical simulations based on these solutions are presented.  It is shown that, for certain combinations of piezoelectric materials and orientations of the applied increasing electric field, the structure will exhibit sling-shot buckling---an instability where the orientation of the deflection of the structure will dynamically change when a critical electric field and critical membrane force are reached.  These critical values are identified from the analytical equations.  A parameter study shows how the critical values depend on various geometric and material properties of the structure.
Musicality and temporality in the art of Nam June Paik (1932-2006)
Creators: name: Oh, Gyung Eun
Publisher: name: No Publisher Supplied
Year: 2014

description: This dissertation is about the influences of Nam June Paik’s musical career in the 1950s over his video art in the following decades. Paik is remembered more as a technology-savvy video artist than as a musicologist and musical composer and his active involvement in New Music and avant-garde musician circles in the mid- to late-1950s. This dissertation points to the fact that the artist’s philosophy of music as a musician developed into the invention of video as an art medium. His musical objective was not simply to produce music but to redefine what music is and to challenge conventional notions of music. Through his incessant quest for an answer to the question, what is music?, Paik established music of his own invention, which evolved into multimedia art.    After a decade of active participation in the discussion of modern music as a musical composer and musician, Paik held his first solo show, “Exposition of Music-Electronic Television,” at Galerie Parnass, Wuppertal, in 1963, in which he showcased a series of television art wired to be visually manipulated according to audio input. This show was a watershed for Paik’s career, as it propelled him into electronic image manipulation through his exploration of music, hence essentially foregrounding Paik’s creation of video art. Before he arrived at this unique combination and visual and audio, he delved into two major components of modern music: one was the idea of Gesamkunstwerk, a term that describes the synthesis of various genres of arts,professed by Richard Wagner and the other was the cutting edge technologies for electronic music in the 1950s. This dissertation addresses that the interesting marriage of the two led Paik to discover the visual aspect of his musical compositions, which expanded his music horizon and enabled him to push the envelope for unique music of his own that subsequently led to the invention of video art.
Sphodromerus undulatus subsp. afghanus Bey-Bienko 1949
Creators: name: Sultana, Riffat
name: Song, Hojun
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Acrididae
Sphodromerus
Sphodromerus undulatus
Sphodromerus undulatus afghanus bey-Bienko, 1949

description: 2. Sphodromerus undulatus afghanus Bey-Bienko, 1949
This species has been reported from Henna Lake, Quetta, Balochistan. The distribution range of this species is only restricted to Afghanistan; occasionally, it is found in Balochistan (Wagan & Sultana 2013; Sultana & Wagan 2015).
description: Published as part of Sultana, Riffat & Song, Hojun, 2024, Annotated catalogue of Pakistani Acrididae (Orthoptera: Caelifera: Acridoidea), pp. 1-47 in Zootaxa 5486 (1) on page 34, DOI: 10.11646/zootaxa.5486.1.1, http://zenodo.org/record/13209743
Paralichthyidae Regan 1910
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Paralichthyidae

description: Family Paralichthyidae Regan 1910 (Fig. 3N). Sand Flounders, Sandabs; Lenguados, Peces Hoja
Description: Body strongly compressed, flattened, oval in shape; up to 150 cm, usually less than 70 cm; eyes on the left side; border of the preoperculum free, not obscured by skin or scales; pectoral fins on both sides of body, with branched rays; pelvic fins on both sides of body, with 5–6 rays, bases short and symmetrical or nearly so; dorsal and anal fins not joined to the caudal fin (Robertson & Allen 2015, Nelson et al. 2016). Distribution: Marine, rarely freshwater; Atlantic, Indian, and Pacific oceans (Nelson et al. 2016). One genus and three species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 42, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Wegeneriella congica Zicsi & Csuzdi 1989
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Octochaetidae
Wegeneriella
Wegeneriella congica

description: Wegeneriella congica Zicsi & Csuzdi, 1989
Wegeneriella congica Zicsi & Csuzdi, 1989 Misc. Zool. Hung. 5: 29.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Novel lanthanide structures
Creators: name: Norton, Kieran James
Publisher: name: No Publisher Supplied
Year: 2014

description: A number of novel lanthanide alkoxide species were synthesized with fluorinated ligands.  This includes monomers with pentafluorophenol, (DME)2Ln(OC6F5)3  (Ln = Nd, Er, Tm, Eu, and Yb), (py)4Ln(OC6F5)3 (Ln = Eu, Tb, Er, Tm, Yb), and (THF)3Yb(OC6F5)3.  Unique europium species, ((py)3Eu(CF3SO3)2)n, (DME)2Eu(µ-OC6F5)3Eu(µ-OC6F5)3Eu(DME)2, and (DME)( C6F5O)2Eu(µ-OC6F5)3Eu(DME)2, were also produced.  Most reactions proceeded by metathesis of lanthanide chalcogenolates, but direct redox reaction of elemental lanthanide with C6F5OH or CF3SO3H catalyzed by Hg also proved to be viable routes.  The Eu(II) trimer was only synthesized through direct oxidation of the metal with the alcohol.  Photoluminescence of (DME)2Ln(OC6F5)3  (Ln = Nd, Er, Tm) was tested, and they exhibited high quantum efficiency for lanthanide monomers.  Two series of dimers, (py)6Ln2(OC6F5)2(µ-η2-SS)2 (Ln = Sm, Eu, and Gd) and (py)6Ln2(CF3SO3)2(Se)x (Ln = Sm, Tm, Yb, and Lu; x = 3 or 4), were synthesized via substitution of EPh-.  The europium dimer is the first example of a Eu(III) molecular sulfido species which is extremely dark due to strong, broad LMCT from the sulfido.  The selenidos display a conspicuous coordination change resulting from the relatively small difference in Ln ionic radii forming (py)6Ln2(CF3SO3)2(µ-η2-SeSe)( µ-Se) for small late lanthanides and (py)6Ln2(CF3SO3)2(µ-η2-Se)2 for larger early lanthanides.  Three fluorido clusters were synthesized without the use of traditional fluoride sources.  (DME)6(py)6Nd18(C6F5O)18 F24O3S3 was produced from a reaction of neodymium phenylselenolate with C6F5OH and sulfur.  (py)8Yb4F8(CF3SO3)4 and (DME)4Tb4(CF3SO3)6F2S2 were synthesized from lanthanide chalcogenolates, elemental chalcogens, and CF3SO3H.  Cleavage of C-F bonds to form these clusters appears to be a slow reaction.  Most reactions producing them took several months.  Lanthanide oxychalcogenido clusters were produced from reacting lanthanide chalcogenolates with pySO3 or TeO2 and Te.  (THF)8Ln8O2S2(SePh)16 (Ln = Ce, Nd) clusters were synthesized from “Ln(SePh)3” and pySO3.  Reactions of “Ln(TePh)3”, TeO2 and Te produced [(py)5Ln3O(Te2)3(TePh)][(py)&Ln4Te(Te2)2(Te2Te(Ph)Te2)(TePh)] (Ln = Ho, Er), [(etpy)11Ho6O4Te4TePh] [Hg(TePh)3] and [(4etpy)12Yb6O4Te4][Hg(TePh)3] [(TePh)3].
Glyphidrilus stuhlmanni subsp. morogoronensis Zicsi 1996
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Glyphidrilus
Glyphidrilus stuhlmanni
Glyphidrilus stuhlmanni morogoronensis zicsi, 1996

description: Glyphidrilus stuhlmanni morogoronensis Zicsi, 1996
Glyphidrilus stuhlmanni morogoronensis Zicsi, 1996 Mitt. Hamb. Zool. Mus. Inst. 93: 21.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 16, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Citharichthys gilberti Jenkins & Evermann 1889
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Paralichthyidae
Citharichthys
Citharichthys gilberti

description: Citharichthys gilberti Jenkins & Evermann 1889. Bigmouth Sanddab; Lenguado Boca Grande, Lenguado Tapadera
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from southern Baja California Sur, Mexico, to northern Peru, inluding the Revillagigedo islands; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN and Ni (Pacific); 0–24 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Villa (1982: 235; detailed description, including illustrations and an identification key, and information on distribution and ecology), Robertson & Allen (2015: 2390; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 42; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 42, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Biosynthesis of Phytosteroids as Novel Chemotherapies
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer, as one of the most deadly diseases, is causing over 1 million deaths in the US, and over 8 million deaths worldwide annually. Although many novel treatment strategies have been developed these days, chemotherapy keeps playing a major role in the treatment of many cancers. There are two major disadvantages when employing chemotherapy treatment: 1) existing anticancer drugs are toxic to many normal cells in addition to cancer cells, and thus cause a long list of adverse effects; and 2) under many circumstances, cancer cells can develop resistance towards the anticancer drugs through mutations. Thus, anticancer agents of higher specificity towards cancer cells with fewer side effects towards normal cells are desired. Plant-derived secondary metabolites have been an important source of anticancer agents, such as taxol and vinblastine. In addition, plants' synthetic potential remains largely under-exploited to date, and thus serves as one significant resources for the discovery and development of new types of anticancer drugs for improved and less toxic cancer treatment. Phytosteroids are a large group of phytochemicals. Among this group, many were shown to efficiently inhibit growth of many human cancer cell lines with no and minimal effect on the growth of normal cells, such as withaferin-A (withanolides) and 24-epibrassinolide (brassinosteroids). Phytosteroids thus serve as a group of promising leads toward the development of new anticancer drugs with few side effects. We propose to elucidate, transform, and engineer the biosynthetic machinery of phytosteroids in baker's yeast through functional genomics and synthetic biology. Further metabolic engineering and combinatorial biosynthesis will enable the efficient production of phytosteroids of verified anticancer activities, and many more that were not isolatable or natively synthesized from nature. The project will be divided into three phases: 1) Elucidation of the biosynthesis of brassinosteroids and withanolides in yeast; 2) Optimization of the P450-rich biosynthetic pathways through metabolic engineering, protein engineering, and fermentation engineering; 3) Pathway engineering and protein engineering for the synthesis of novel natural and unnatural phytosteroids. The phytosteroids synthesized from this project will be eventually examined and evaluated in collaborating laboratory.
A Tale of Two Refugees: Disparities in the Treatment of Ukrainian and Non-Ukrainian Refugees in Europe
Creators: name: Anindita Das Mimi
name: Nazmul Islam Chowdhury*
Publisher: name: Zenodo
Year: 2024
Subjects: Refugee Crisis in Europe, Discrimination among Refugees, Human Rights Protections, Geopolitics in Protection Mechanism, observance of International Refugee Law.

description: Abstract: This article examines the differential treatment of Ukrainian refugees compared to those from other regions, particularly the Middle East and Africa, within the European Union. While the EU has demonstrated a swift and substantial response to the Ukrainian refugee crisis, inconsistencies in the application of refugee rights and protection mechanisms have emerged. The paper delves into the key rights enshrined in international refugee law and analyzes their implementation in the context of Ukrainian refugees. It highlights disparities in access to asylum procedures, temporary protection measures, and social services. The potential long-term implications of these disparities for refugee integration and EU refugee policy are explored. Furthermore, the paper discusses the geopolitical factors influencing the EU's response to the Ukrainian refugee crisis and the potential impact of the 2024 US presidential election on global refugee resettlement efforts. It concludes by proposing policy recommendations to ensure equitable treatment of all refugees and strengthen international cooperation in addressing the global refugee crisis.
Investigating the Roles of the ER Regulation in Mitosis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The importance of accurate and coordinated cell cycle division is underscored by human diseases such as cancer that are caused by uncontrolled cell division. Thus far, studies of cell cycle checkpoints that ensure proper cell division have centered around chromosome replication and segregation. Little is known about the existence of cell cycle checkpoints that monitor the fidelity of cytoplasmic organelle divisions. In recent work, we discovered a cell cycle checkpoint that ensures inheritance of functional endoplasmic reticulum (ER) during cell cycle in S. cerevisiae. The ER, one of the biggest organelles in the cytoplasm, plays vital roles in the production of secretory proteins, lipid biosynthesis, and detoxification. Importantly, the ER cannot be generated de novo. We found that ER stress blocks ER inheritance into the daughter cell, leading to a halt in the cell cycle by the mislocalization of the septin ring away from the bud neck and cytokinesis block. A failure to halt the inheritance of stressed ER causes cell death, highlighting the importance of this checkpoint. The major goal of this proposal is to investigate in detail how cells ensure functional quality of the ER during the cell division. As the nuclear membrane breaks down during the cell cycle, nuclear membrane proteins and lipids are dispersed into the ER and are retrieved back to the nuclear membrane as it reassembles during anaphase. We obtained preliminary results revealing that the reassembly of the nuclear membrane is delayed in mammalian cells in response to ER stress, leading to the cytokinesis delay by mislocalizing septin rings from the midbody. In some cancer cells, ER stress and the components of the unfolded protein response, a signaling pathway for establishment of ER homeostasis, are highly induced. Thus, we hypothesize that the functional homeostasis of the ER impacts nuclear membrane assembly/disassembly, which may provide a basis for the cell division checkpoint that ensures divided cells have functional ER. In this proposal, we will (1) dissect the molecular events and mechanisms leading to the ER stress-induced delay in nuclear membrane reassembly, (2) interrogate the impact of ER stress on other mammalian cell cycle stages, and (3) evaluate the impact of modulating unfolded protein response component activities on ER stress-affected cell cycle events.
Citharichthys spilopterus Gunther 1862
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Paralichthyidae
Citharichthys
Citharichthys spilopterus

description: Citharichthys spilopterus Günther 1862 (Fig. 8C). Bay Whiff; Lenguado Pardo
Vouchers: UCR 0269-005 (1) and 0363-016 (1); other collections: IBUNAM 13793 (1). Distribution: Western Atlantic Ocean; from New Jersey, USA, to the Antilles and southern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Pr, GM, KP, Es, BF, IM, To, Sa and SJ (Atlantic); 0–30 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2015), population trend stable. Literature: Villa (1982: 235; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 428; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), González-Alemán (2006: 85; brief description, including an illustration, and information on distribution and ecology), van den Berghe (2015: 48, as Citherichthys spilopterus —misspelled; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 4289; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 43; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 42, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Buettneriodrilus bicaliculatus subsp. sibitianus Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Buettneriodrilus
Buettneriodrilus bicaliculatus
Buettneriodrilus bicaliculatus sibitianus zicsi & csuzdi, 1986

description: Buettneriodrilus bicaliculatus sibitianus Zicsi & Csuzdi, 1986
Buettneriodrilus bicaliculatus sibitianus Zicsi & Csuzdi, 1986b Acta Zool. Hung. 32: 400.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Buettneriodrilus pseudosulcatus Zicsi & Csuzdi 1986
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Opisthopora
Eudrilidae
Buettneriodrilus
Buettneriodrilus pseudosulcatus

description: Buettneriodrilus pseudosulcatus Zicsi & Csuzdi, 1986
Buettneriodrilus pseudosulcatus Zicsi & Csuzdi, 1986b Acta Zool. Hung. 32: 394.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 17, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
MOESM1 of Genetic model misspecification in genetic association studies
Creators: name: Amadou Gaye
name: Davis, Sharon
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: Additional file 1. Further details about the simulations, parameter settings and results in table format.
Citharichthys uhleri Jordan 1889
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pleuronectiformes
Paralichthyidae
Citharichthys
Citharichthys uhleri

description: Citharichthys uhleri Jordan 1889. Voodoo Whiff; Lenguado Albimoteado
Vouchers: Not available. Distribution: Western Atlantic Ocean; from southern Gulf of Mexico to the sothwestern Caribbean and nothern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) KP, Es and To (Atlantic); 0–8 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; DD (2021), population trend unknown. Literature: Villa (1982: 235; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 430; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Robertson & Van Tassell (2019: 4688; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 43; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 42, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788