cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Validation of the role of miR-483-5p in cholangiocarcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cholangiocarcinoma (CCA) arises from the epithelial cells lining the bile ducts and carries a dismal prognosis. Primary sclerosing cholangitis (PSC), an autoimmune disease that targets the bile ducts, is the most significant risk factor for CCA with a 1% annual incidence of CCA in PSC patients. Early detection offers CCA patients some hope of cure. However, screening tests including serum CA19-9 and imaging are of limited value due to low sensitivity. In addition, when CCA is suspected, invasive tests have limited negative predictive values. Therefore, novel biomarkers for screening of high-risk groups such as PSC patients and for diagnosis are critically needed. Further, such biomarkers may potentially lead to novel therapeutic approaches. We have a long-standing interest in PSC and have recently begun to address the issue of CCA surveillance in this population. In a pilot study, we demonstrated that serum micro(mi) RNA expression patterns are distinct between CCA, PSC and healthy controls, providing a basis for the use of miRNAs as biomarkers for CCA surveillance. Importantly, miR-483-5p was expressed at greater levels in the serum of patients with CCA compared to patients with PSC without CCA, primary biliary cholangitis (another autoimmune disease of the bile ducts), and healthy controls, indicating that miR-483-5p is specific for CCA. However, it is unclear whether this microRNA is directly derived from the cancer cells or from the local responding cells or neighboring tissues. In addition, the molecular mechanism of action of miR-483-5p in tumorigenesis remains unknown. In this application, we will address these issues by: 1. testing if miR-483-5p is induced in CCA by comparing the expression of miR-483-5p in CCA tumor tissues versus adjacent non-tumor tissues and the expression and secretion of miR-483-5p in primary biliary epithelial cells versus biliary cancer cell lines; and 2. evaluating the effects of induced and repressed expression of miR-483-5p in CCA cell lines relative to cell motility, invasion and metastasis. This work will further support miR-483-5p as a novel biomarker for CCA surveillance; lay the groundwork for future investigations into the role of miRNA-483-5p in CCA; and determine the potential of a miRNA-based target for CCA.
Updated master plan, Borough of Lodi, N.J.
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1973

description: This report is in two parts; the first part contains a summary of the salient findings of the preliminary studies to update the Master Plan; they include: very little vacant land left, slight population growth, net-out migration; deleterious heavy industrial zoning and a need to improve the environment; a need for more rental housing units, a deficiency of parks and play space including undersized school sites, a need for a new Borough Hall and Library. The second part of the report contains the updated master plan elements: proposed land use plan, community facilities plan and an implementation plan which seek to remove deficiencies and to correct the problems found.
Micro/Nanofabricated Ceramic Blade Arrays for Shaving and Surgery
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In this project, we propose the fabrication of high aspect ratio ceramic/semiconductor walls with sharp cutting edges and transfer-printing them onto polymer substrate layers as blade components/inserts for applications in shaving, hair removal and surgery. Conventional metal blades oxidize after a few uses and experience a reduction in sharpness over time from micro-chipping and bur formation. Further, the cutting edge profile, sharpness, size and angles of current blades are all the same. Polishing may cause conchoidal fracture in ceramics or semiconductors which is not an issue if controlled micro/nano-fabrication (MNF) processes such as wet/dry etching, coating with passivation, hydrophobic/hydrophilic films are used for blade manufacturing. Variations in the angle, size, sharpness and physical properties can help in optimizing shaving/cutting experiences. We developed a technology to use ceramics/semiconductors (e.g. silicon, silica, aluminum nitride, silicon carbide, boron nitride, diamond, diamond-like-carbon etc.) and take advantage of the existing matured and low-cost MNF technologies to fabricate a large array of sharp blades with controlled sharpness, sizes, orientation and with integrated micro-capillary for fluid flow (such as shaving lubricant delivery during shaving) on low-cost substrates such as plastics and metal foils. MNF can also offer arbitrary positioning capability of individual blades in an array with nanoscale precision and can enable flexible packaging opportunity. We will fabricate ceramic/semiconductor blades, transfer-print them onto secondary substrates, orient them at an arbitrary angle (sharp edge at arbitrary angle with respect to the blade-axis and arbitrarily orientated during packaging) and integrate microfluidic flow channels for shaving lubricants. This invention will take advantage of UC Case # 2008-584 and 2012-467. Closely spaced blades fabricated on a wafer can be transferred onto a flexible tape to controllably separate them by stretching the tape. This will help in efficiently using blade materials and producing a large number of blades from a small wafer.
Eucinostomus jonesii
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gerreidae
Eucinostomus
Eucinostomus jonesii

description: Eucinostomus jonesii (Günther 1879). Slender Mojarra; Mojarrita Esbelta, Mojarra Flaca
Vouchers: Not available. Distribution: Western Atlantic Ocean; from Florida, USA, to central Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) KP and Es (Atlantic); 0–4 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2015), population trend unknown. Literature: Villa (1982: 178; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Van Tassell (2019: 3707; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 72, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
IPM Decisions branding and templates
Creators: name: Ramsden, Mark
Publisher: name: Zenodo
Year: 2024
Subjects: IPM Decisions branding
IPM Decisions Templates

description: Horizon 2020 project IPM Decisions - Stepping-up IPM decision support for crop protection.

Attached are various IPM Decisions branded resources, files, and templates for use in exploiting and promoting the IPM Decisions platform. All resources must cite the project, and only be used to promote the IPM Decisions platform and assocaited activities.
Plasmonic Nanolaser for Data Comm. & Biomedical Applications
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We propose a 12-month project to accelerate the commercialization of UC Berkeley's patented Plasmonic Nanolaser technology. The proposed project will attract corporations and venture capitals by demonstrating great market potentials offered by this innovative technology. The global healthcare equipment market was valued at $272 billion in 2010 and is forecast to grow to $401 billion by 2015, with a huge demands for miniaturized optical-medical equipments. At the same time, the rapid increase of portable computing devices such as smart phones and tablet computers (536 million units sold in 2011 and expected to reach 1.3 billion in 2015) are also driving exponential growing demands for next generation of data routing platforms such as photonic integrated circuits (PIC). However, traditional photonic chips are facing severe difficulties such as large size mismatch with their electrical counterparts, and limited performance in terms of power consumption, due to their material limits and physical restrictions. Our invention of Plasmon Nanolaser technology provides the world's first platform to generate coherent light at nanometer scale efficiently. The enhanced light-matter interaction associated with nanoscale devices enables ultra-small light source with high speed. Furthermore, by matching optical and electronic device scales for the first time, one will have the opportunity to make such systems ideal light sources for the next-generation photonic integrated circuits at dimensions the same as or much smaller than current transistor technology with superior performances. In this project, we propose to build a prototype on-chip laser system for high volume data communications. Outstanding prototype performance with refined material and packaging choices satisfying industrial and safety standards will prove the commercialization capability of this technology, which will result in this emerging technology licensed to companies that have shown a great interest on our invention, or attracting venture capital forms for startup financing.
Euscorpius gulhanimae Yağmur, 2024, sp. n.
Creators: name: Yağmur, Ersen Aydın
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Euscorpiidae
Euscorpius
Euscorpius gulhanimae

description: Euscorpius gulhanimae sp. n.
(Figures. 1–36, Table 1)
description: Published as part of Yağmur, Ersen Aydın, 2024, Euscorpius gulhanimae sp. n. from the Konya Province, Turkey (Scorpiones: Euscorpiidae), pp. 1-13 in Euscorpius 393 on page 3, DOI: 10.5281/zenodo.14660251
Novel hydrogel for stem cell and cardiomyocyte research
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Three-dimensional cell culture system has become increasingly important in stem cell research and functional studies of adult cells such as cardiomyocytes. Several 3D gel matrix are now commercially available for growing cells: Matrigel, Geltrex, and MaxGel contain products derived from mouse cells and animal tissues. AlgiMatrix is macroporous material derived from brown seaweed. HydroMatrix and PuraMatrix, are synthetic peptides that self-assemble into a 3D gel matrix with the addition of salt. Extraction of cells from most of the above mentioned gel matrix require enzymes which could be damaging to cells. There is a need for the development of a totally synthetic, chemically well-defined, inexpensive and highly versatile 3D gel that allows researchers to grow stem cells and adult cells for biomedical research and for stem cell therapy. We have recently developed a novel polyvinyl alcohol (PVA) hydrogel comprised of PVA and boronate-PEG crosslinker. Ligands that bind to specific cell types can be conveniently incorporated into the gel matrix. We have successfully grown and maintain stem cells in such 3D gel culture system for over 4 weeks. Our hydrogel is totally synthetic, inexpensive to prepare and can be scaled up for mass production. The unique reversible crosslinking chemistry of the hydrogel also allows us to easily retrieve the cells under very gentle condition without using enzymes. Together, these attributes make the PVA hydrogel an attractive tool for stem cell research and as useful 3D synthetic matrix for tissue engineering and regenerative stem cell therapy. Preliminary study on adult cardiomyocte in our PVA hydrogel has revealed significant impact of the mechanical stress on the Ca2+ signaling and contraction dynamics in cardiomyocytes. Using this system we also identified important cellular signaling pathways that link mechanical stress to cardiac arrhythmias. Such important study could not have been done without this novel PVA hydrogel system. In this UC Discovery project, we plan: (1) to incorporate into the PVA hydrogel matrix our recently discovered molecules that can direct stem cell to differentiate into precursor nerve cells, and to optimize the use of the hydrogel in the scale-up production of precursor nerve cells; and (2) To develop this PVA hydrogel system into a valuable device for controlling mechanical stress at single cell level so that in-depth study of the heart disease mechanisms can be conducted.
Andiodrilus vaucheri Zicsi 1988
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Andiodrilus
Andiodrilus vaucheri

description: Andiodrilus vaucheri Zicsi, 1988
Andiodrilus vaucheri Zicsi, 1988b Rev. suisse Zool. 95 (3): 718.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 29, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
An autoantigen biomarker for autoimmune-mediated lung disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Interstitial lung (ILD) is a complex disorder characterized by inflammation or scarring in the lung. A physician may suspect that a patient develops ILD because their lungs are overreacting to substances in the air or maybe because they have a separate illness (e.g. rheumatoid arthritis) that is abnormally affecting the lung. More often than not, the cause of ILD is never discovered largely because physicians generally have a poor understanding of why and how the lung becomes damaged in this disorder. The consequence of all of this for many ILD patients is that there are a limited number of drugs to treat ILD since the physician is never quite sure why ILD has occurred and as a result, does not know how to effectively combat the lung damage. ILD that has not been treated often leads to progressive lung scarring that hampers a patient’s ability to breath and get enough oxygen to vital organs. Our group has developed a novel antibody test that can be used to identify patients who develop ILD because their immune system is abnormally attacking a specific protein in the lung called BPIFB1. This finding is especially important for four reasons: 1) patients with an established autoimmune disorder can be treated with drugs to suppress their immune system to prevent it from attacking the lung; 2) patients with ILD and an established autoimmune disorder tend to have better outcomes; 3) the identification of specific proteins being attacked by the immune system allows researchers to develop therapies that avoid dangerous side effects of generalized immunosuppressive drugs and 4) to develop a test that may predict which patients will develop autoimmune ILD. In summary, our findings suggest that a simple blood test can be used to determine which patients might benefit from immunosuppressive treatment to combat autoimmune lung inflammation and scarring.
Eucinostomus melanopterus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gerreidae
Eucinostomus
Eucinostomus melanopterus

description: Eucinostomus melanopterus (Bleeker 1863). Flagfin Mojarra; Mojarra Bandera, Mojarrita de Ley, Comearena, Palmito
Vouchers: UCR 0363-021 (4). Distribution: Atlantic Ocean; from Bermuda and Florida, USA, to Brazil, in the western Atlantic, and from Senegal to Angola and Mauritania, in the eastern Atlantic; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) KP and BF (Atlantic); 0–4 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2015), population trend unknown. Literature: Villa (1982: 178; detailed description, including illustrations and an identification key, and information on distribution and ecology), van den Berghe (2015: 43, as Eucinostomus currani Zahuranec 1980 —misidentification; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 3709; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 64; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 72, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Andiorrhinus (Andiorrhinus) montanus Zicsi 1995
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Andiorrhinus
Andiorrhinus montanus

description: Andiorrhinus (Andiorrhinus) montanus Zicsi, 1995
Andiorrhinus montanus Zicsi, 1995b Rev. suisse Zool. 102: 592.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 29, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
In Vivo Diagnostics for Cardiovascular Disease
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. No tools are commercially available to quantify the enzymatic activity of the individual proteases associated with CVD progression from a benign inflammatory state into a fatal thrombotic one. Our goal is to commercialize reagents and diagnostics to address this need. Our enzyme-activated probes deliver imaging agents that “paint” cell membranes near sites of particular enzyme activities for their detection in live animals using near infrared or nuclear imaging. Our tools provide researchers and clinicians previously inaccessible quantitative information about where, when and how much of each of these enzymes are generated in vivo, non-invasively, in real-time with spatial context and high sensitivity. Such tools have considerable value for studying physiology whether it occurs in animal models of human disease or a patient with a suspected thrombotic condition. In turn, this enables better understanding about how this biology works and can alter treatment regimens. Our proposal builds upon successful UCSF Clinical & Translational Science Institute T1 Catalyst grant funding in which we: (1) validated a series of compounds that target thrombin, (2) demonstrated the ability to deliver optical and nuclear imaging agents, (3) identified lead candidates for targeting proteases upstream of thrombin in the coagulation cascade and inflammatory proteases that precede clot formation in atherosclerosis, (4) expanded our patent position, and (5) attracted interest from several biotechnology and pharmaceutical companies. We have assembled a collaborative network consisting of a number of leaders at UCSF including Drs. Shaun Coughlin, Ethan Weiss, Byron Hann, Leslie Benet and Henry VanBrocklin whose expertise spans the range of techniques and instrumentation necessary to advance the project into the commercial arena. Our preliminary studies highlighted the value of a more detailed animal study that emphasizes the dynamic range and reproducibility of our probes in determining the efficacy of anticoagulant drugs and motivates this proposal. The data generated in these studies will increase the likelihood of licensing the technology to commercialize the developmental reagents as research tools as well as clinical diagnostics.
Robust detection and genotyping of CTCs in blood
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The detection of Circulating Tumor Cells (CTCs) is heralded for its potential to diagnose cancer at an early stage. These cells are shed from tumors into the blood stream and thus provide material directly from tumors anywhere in the body, which can be used for genetic and proteomic profiling of the patient’s cancer. However, existing methods for detecting and analyzing this are of limited utility, due to their inaccuracy and cost. Essentially all commercial systems use the same approach: antibodies that specifically bind to the CTCs recover them from the blood. While over a decade of research has gone into optimizing this approach, it still remains of limited clinical value. The goal of our research will be to initiate a new paradigm in CTC detection that will not really on antibodies, but instead will detect and analyze CTCs using detailed and very high throughput genetic profiling. These assays will detect all CTCs and also provide, for every CTC detected, a list of its cancer-associated mutations, including in known oncogenes like BRAF, KRAS, and PI3KCA, and tumor suppressor genes like TP53. This will provide detailed genetic data on each cell that will be useful for diagnosing and staging the disease, assessing its metastatic potential, and identifying the best treatment options based on personalized genetic factors of the patient. The use of microfluidics will allow this analysis to be performed in 20 min for a cost of $0.10 in reagent, making it feasible for routine blood testing.
Dichotomius (Cephagonus) fissus
Creators: name: Nunes, Rafael V.
name: Vaz-de-Mello, Fernando Z.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Dichotomius
Dichotomius fissus

description: Group 2: Dichotomius (Cephagonus) fissus (Harold) species-group
Diagnosis. among Cephagonus ı this species group is separated by the following combination of characters: clypeo-genal angle sub-straight in malesı obtuse in females (as in spadiceus and some species of ascanius and quadraticeps groups); anterior portion of pronotum with wide emargination and/or declivity (Figure 16 (a)); elytral interstriae flatı weakly impressed and/or with shiny blue or copper hue near the base and/or with microsculpture (as in D. mundus and D. baiano) (Figure 9 (b-e)) and female sixth abdominal ventrite with a pair of triangular projections reaching pygidium margin (as in spadiceus group) (Figure 7 (b)).
Representatives. 2.1: D. fissus; 2.2: D. fonsecae; 2.3: D. baiano; 2.4: D. fernandosilvai ı 2.5: D. filgueirasi; 2.6: D. seag.
description: Published as part of Nunes, Rafael V. & Vaz-de-Mello, Fernando Z., 2019, Taxonomic revision of Dichotomius (Cephagonus) Luederwaldt 1929 and the taxonomic status of remaining Dichotomius Hope 1838 subgenera (Coleoptera: Scarabaeidae: Scarabaeinae: Dichotomiini), pp. 2231-2351 in Journal of Natural History 53 (37) on pages 2294-2295, DOI: 10.1080/00222933.2019.1692088, http://zenodo.org/record/3665519
Eugerres brevimanus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gerreidae
Eugerres
Eugerres brevimanus

description: Eugerres brevimanus (Günther 1864). Shortfin Mojarra; Palmito Aleta Corta, Mojarra, Comearena, Palometa
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from central Mexico to northen Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN and Ni (Pacific); 0–22 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Villa (1982: 176, as Diapterus brevimanus —synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 282; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), Robertson & Allen (2015: 1337; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 64; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 73, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Self-healing Multiphase Polymers for Coating Applications
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The ability to spontaneously heal injury is a key biomaterial feature that increases the survivability and lifetime of most plants and animals. In sharp contrast, synthetic materials usually fail after damage or fracture. We recently demonstrated a biomimetic “molecular Velcro” approach to design multi-phase self-healing materials that can spontaneously repair themselves under ambient conditions after mechanical damage (Nature Chemistry, 2012, in press). Our approach is to program dynamic attractive interactions in the soft phase of a hard/soft multiphase system to yield dynamic nanocomposites that combine key mechanical properties (strength, toughness, and elasticity) with the ability to self-heal after damage. This design concept is general for a wide range of materials including elastomers, plastics, and composites. In contrast to other self-healing systems, we achieve this unique performance profile without the need of any additives, healing agents, or external stimuli, and functionality is retained over multiple damage/healing cycles. These advantages, along with the simple and scalable synthesis, make our system highly promising for the development of commercial self-healing materials with dramatically improved safety, lifetime, energy efficiency, and environmental impact. Specifically, we want to explore the applications of our self-healing materials for failure-proof protective coatings and barrier membranes. With the support of this Commercialization Gap Grant, we will demonstrate practical utility of our materials and develop proof-of-concept prototype products for such applications, which should enable us to attract industrial sponsors and venture capitals for further commercialization development.
Eugerres lineatus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gerreidae
Eugerres
Eugerres lineatus

description: Eugerres lineatus (Humboldt 1821). Streaked Mojarra; Mojarra Cahuacha, Mojarra China
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from Baja California Sur, Mexico, to Ecuador; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) PN (Pacific); 0–5 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Villa (1982: 176, as Diapterus lineatus —synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Allen (2015: 1338; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 73, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
2D device to test deformable image registration in medicine
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Deformable registration algorithms are mathematical tools that compare the image intensity of two patient scans and solve for a transformation that best maps the locations of the anatomy on one scan to the other. These algorithms have many powerful applications in medicine. For example, a patient scan that was contoured to delineate different regions of the anatomy can be registered to another scan and the derived transformation can be used to automatically delineate the second scan. Different types of deformation algorithms generate very different transformations and the results of any one algorithm can be misleading. Deformable registration is already used clinically; thus, errors therein could affect patient treatment. However, there is not currently a solid method to demonstrate exactly how well these algorithms work. This is the role of the proposed device. There are other methods of performing quality assurance for deformable registration, but they have several shortcomings. One example is landmark tracking, which compares the motion of landmarks that are visible in the scans to the predictions of a deformation algorithm. The problem with this method is that any prominent landmark will also stand out to the algorithm and yield a skewed view of accuracy. The purpose of the proposed device is to objectively measure deformation accuracy without perturbing the deformation algorithm. This is done by using nonradiopaque landmarks, which do not appear on scans and therefore do not influence the registration. These landmarks are distributed across the surface of a two-dimensional anthropomorphic phantom and then optical camera images of the landmarks are used to measure the deformations. The reduction of the deformable anatomy to a two-dimensional system allows for the use of these nonradiopaque markers, which do not influence deformation algorithms. This is the fundamental advantage of this verification technique.
Pre-Clinical Evaluation of a Novel Inhaled Anesthetic
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Using water solubility as a predictor of anesthetic-sensitive receptor effects (a technique discovered by our laboratory), we identified a limited number of volatile, non-flammable, and novel candidate inhalation anesthetics. We first studied 1,1,2,2,3,3,4-heptafluorocyclopentane (HFCP), an odorless and colorless polyfluorinated hydrocarbon ring. In vitro electrophysiology studies show that HFCP potentiates GABA-A receptors, glycine receptors, and TRESK channels, but unlike conventional inhaled anesthetics, does not affect NMDA receptors. This difference means that HFCP may be devoid of adverse effects putatively attributed to NMDA receptor inhibition (e.g., behavioral excitation, neuronal death, hypotension, abnormal breathing patterns, etc.). HFCP has low oil and water solubility and a high partial pressure. These physical properties permit sufficient vapor concentrations for anesthesia based on the Meyer-Overton principle, and should confer desirable and rapid onset kinetics and rapid elimination during anesthetic recovery. This was verified in three Swiss-Webster mice: HFCP rapidly and reversibly produced loss-of-righting (a measure of unconsciousness) with no apparent excitement, coughing, or adverse CNS effects, and mice recovered from anesthesia within 1 minute after discontinuing the inhaled anesthetic. To increase pharmaceutical company interest in future licensing of this discovery, we need to better characterize the actions of HFCP. We propose the following 4 Aims as part of early pre-clinical testing on HFCP necessary to support its safety, efficacy, and suitability as a general anesthetic: Aim 1: Measurement of HFCP potency in Fisher-344 rats and in dogs. Tissues from rats will be collected for histopathology, and blood and urine from dogs will be collected for hematologic and biochemical analysis. Aim 2: Pharmacokinetic modeling of HFCP and comparison with isoflurane (a common clinically-used inhaled anesthetic). Aim 3: Measurement of dose-dependent cardiovascular and respiratory effects of HFCP and comparison to cardiorespiratory effects of isoflurane in dogs. Aim 4: Comparison of HFCP versus isoflurane effects on epinephrine-induced arrhythmias in dogs.
Amphiphala landryana Brown 2024, new species
Creators: name: Brown, Michael A. Roberts Michael Sabourin John W.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Tortricidae
Amphiphala
Amphiphala landryana

description: Amphiphala landryana Brown, new species
Fig. 5, 15
Diagnosis. Superficially, A. landryana is indistinguishable from its congeners (Fig. 3–6), although the holotype female is slightly larger than many other congeners. The female genitalia of A. landryana (Fig. 15) are most similar to those of A. liatriana (Fig. 12–14), but they can be distinguished from those of the latter by the much larger sublateral sclerites of the recurved median ventral lobe (the lobe best shown in Fig. 14).
Description. Head. Vertex and frons whitish yellow; [labial palpus missing]; antennal scape with pale yellow scales, flagellomeres with tan gray scales.
Thorax. Notum concolorous with head; tegula slightly darker basally. Under surface pale yellow. Forewing length 6.0 mm (n = 1); forewing ground color white, overlaid with pale yellow and pale tawny scales; median fascia broad, subtriangular, its base occupying medial 0.33 of hind margin, its truncate apex occupying medial 0.12 of costa, blackish brown, with irregular patches of silvery gray near dorsal margin; preapical fascia small, fuscous, with scattered black and rust scales; fringe concolorous with ground color. Underside gray with contrasting pale yellow ochre costal striae in postmedian and subterminal areas. Hindwing mostly whitish with limited pale gray overscaling; fringe pale yellowish gray. Underside pale yellowish gray.
Abdomen. Pale yellow dorsally, slightly paler ventrally. Male genitalia unknown. Female genitalia (Fig. 15) as described for genus, except rounded recurved process posterior to ostial plate with two long, slightly curved, sublateral sclerites; ductus bursae densely spiculate.
Type. Holotype ♀, Canada, Manitoba, Manitoba Tall Grass Prairie Preserve, Prairie Trail, 289 m, 49.0730, -967740, 18 Jul 2007, MV light, J.-F. Landry & V. Nazari, CNCLEP00040582, USNM slide 154,796 (CNC).
Biology and distribution. This species is known only from the holotype collected in prairie habitat in southernmost Manitoba, Canada, in mid-July.
Etymology. The specific epithet is a patronym for our lifelong friend Jean-François Landry, the collector of the holotype specimen. It is considered an adjective, and the suffix “-ana” is a traditional ending for tortricid species names.
description: Published as part of Brown, Michael A. Roberts Michael Sabourin John W., 2024, Amphiphala, a new genus and its three new species from eastern North America (Lepidoptera: Tortricidae: Cochylina), pp. 1-12 in Insecta Mundi 2024 (70) on page 7, DOI: 10.5281/zenodo.14662264
Eugerres plumieri
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Gerreidae
Eugerres
Eugerres plumieri

description: Eugerres plumieri (Cuvier 1830) (Fig. 10B). Striped Mojarra; Mojarra Rayada, Patao Rayado, Comearena, Palmito, Palometa
Vouchers: UCR 0363-008 (11) and 1081-001 (1); LSUMZ 15309 (5), 15326 (5), 15345 (9), 15358 (7) and 15422 (1); other collections: KU 22702 (1) and UF 233935 (1). Distribution: Western Atlantic Ocean; from South Carolina, USA, to northern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) Co, UI, WK, Pr, KP, Es, BF, IM, To, Sa, SJ, RF and LN (Atlantic); 0–31 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2015), population trend stable. Literature: Fowler (1923: 29, as Gerres plumieri — synonym; listed, including information on distribution), Villa (1982: 176, as Diapterus plumieri —synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology), González-Alemán (2006: 70; brief description, including an illustration, and information on distribution and ecology), Gros & Miguel-Frithz (2010: 133; brief description, including illustrations, and information on distribution and ecology, plus indigenous science and ethnoichthyology), van den Berghe (2015: 42; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 3711; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 65; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 73, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Back-Side Readout Silicon Photomultiplier
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The objective of this proposal is to develop a novel solid-state photodetector with excellent photon-counting capability, low operating voltage, and insensitivity to magnetic fields. Solid-state photodetectors such as avalanche photodiode (APD) and Geiger-mode APD (also known as silicon photomultiplier) provide further benefits of compact size and low weight than conventional photodetectors, typically photomultiplier tubes (PMTs). While the advantages of solid-state photodetectors can be useful in a variety of applications, including medical imaging, biophotonics, threat detection, optical communication, and particle physics, our objective is developing the silicon photomultiplier (SiPM) for medical imaging applications. An SiPM is a large number of small identical avalanche photodiodes (micro-cells) operating in Geiger-mode and arranged in a matrix. Many research groups and commercial manufacturers have developed their versions of an SiPM. One drawback of current designs of SiPMs is that the signals are read out from the front side of the device. Any active or passive structures fabricated on the front surface of the device reduce the active area for photon detection. Generally, the current SiPM with small micro-cell size has a relatively small fill factor (the fraction of total area occupied by the active micro-cell areas), which reduces the photon detection efficiency (PDE). We propose a novel design of the SiPM that increases the fill factor and consequently the PDE by bringing the electronic signal from each micro-cell of the SiPM to the back side of the structure using 3D microfabrication. In addition, active or passive components can be fabricated on the back side without affecting the active area of the micro-cell on the front side where the incident photons are impinging. The electronic signals from the micro-cells that are brought out to the back side can also be coupled to an application-specific integrated circuit (ASIC) for signal processing.
Andiorrhinus (Amazonidrilus) aberratus Zicsi & Csuzdi 1999
Creators: name: Csuzdi, Csaba
name: Szederjesi, Tímea
name: Sherlock, Emma
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Andiorrhinus
Andiorrhinus aberratus

description: Andiorrhinus (Amazonidrilus) aberratus Zicsi & Csuzdi, 1999
Andiorrhinus (Amazonidrilus) aberratus Zicsi & Csuzdi, 1999a Senck. biol. 78: 130.
description: Published as part of Csuzdi, Csaba, Szederjesi, Tímea & Sherlock, Emma, 2018, Annotated checklist of earthworm species described by András Zicsi (Clitellata: Megadrili), pp. 11-42 in Zootaxa 4496 (1) on page 30, DOI: 10.11646/zootaxa.4496.1.4, http://zenodo.org/record/1447011
Hydrogène en sidérurgie: État de l'art, exigences et défis pour les matériaux réfractaires
Creators: name: Ribeiro Gomes, Milena Amábilis
Publisher: name: Zenodo
Year: 2024
Subjects: hydrogen
refractories
corrosion
DRI
H2 combustion

description: Hydrogène en sidérurgie: État de l'art, exigences et défis pour les matériaux réfractaires
Cancer Disparities in Young Adults with Medicaid Insurance
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer incidence in adolescent and young adults (AYAs: ages 15 to 39 years) is increasing and the leading cause of non-accidental deaths in this age group. While great strides in survival have occurred for younger and older cancer patients, less improvement has occurred among AYAs. Factors contributing to lesser progress in survival include poor access to health and supportive care, as AYAs have historically been the most highly uninsured in the USA. Nationally-representative studies have found that lacking insurance or having public health insurance at diagnosis or initial treatment were associated with diagnosis at an advanced stage, under-treatment and worse survival among AYAs with cancer. Our own work in California found an over 50% increased risk of cancer mortality among AYAs without private insurance. Prior to the Affordable Care Act (ACA), California extended Medicaid coverage to eligible uninsured patients after a cancer diagnosis. As a result, we were previously unable to distinguish those who were uninsured from those who were publicly insured at the time of diagnosis. As those who join Medicaid at diagnosis may miss out on cancer screening and other non-emergent care, it is important to identify patients uninsured at the time of diagnosis. Indeed, compared with being enrolled >6 months prior to diagnosis, Medicaid enrollment at diagnosis was associated with being diagnosed at a more advanced stage, fewer definitive operations and higher one-year mortality in older patients (mean age, 54 years) with selected cancers. However, no study has focused on continuous Medicaid enrollment in the highly uninsured AYA population or compared outcomes to AYAs with private insurance to estimate the potential gap in quality of care. Therefore, we propose to link Medicaid enrollment files to California Cancer Registry data for AYAs diagnosed with the twelve most common cancers during 2001-2013 and determine the impact of health insurance (uninsured, Medicaid insured prior to cancer diagnosis, Medicaid insured at diagnosis or privately insured) on stage at diagnosis, time to and type of treatment, and cancer-specific survival. With the expansion of Medicaid in 2014 as a source of health insurance in California, it is important to determine the effect of health insurance status on vulnerable subgroups of patients at risk for poor cancer outcomes as well as provide preliminary data for studies that assess health care utilization and cancer outcomes after implementation of the ACA.