title: Ð­ÑÑÐµÐºÑ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ Ð½Ð° ÑÐ°Ð·Ð½ÑÑ ÑÑÐ°Ð´Ð¸ÑÑ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Effect of electrical stimulation on different stages of epileptic activity
Creators: name: ÐÑÑÐµÑ, ÐÐ°Ð½Ð¸Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð²Ð¸ÑÐ¾ÑÐ½Ð°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
4-Ð°Ð¼Ð¸Ð½Ð¾Ð¿Ð¸ÑÐ¸Ð´Ð¸Ð½Ð¾Ð²Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸
ÑÐ¸ÑÑÐµÐ¼Ð° Ð¾Ð±ÑÐ°ÑÐ½Ð¾Ð¹ ÑÐ²ÑÐ·Ð¸
Ð½Ð¸Ð·ÐºÐ¾ÑÐ°ÑÑÐ¾ÑÐ½Ð°Ñ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ñ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸
temporal lobe epilepsy
4-aminopyridine model of epilepsy
closed-loop system
low-frequency electrical stimulation of the brain tissue

description: ÐÐ¸ÑÐ¾ÑÐ½Ð°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ Ð² 30% ÑÐ»ÑÑÐ°ÐµÐ² Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑÑÑ ÑÐ°ÑÐ¼Ð°ÐºÐ¾ÑÐµÐ·Ð¸ÑÑÐµÐ½ÑÐ¾Ð¹, Ð²ÐµÐ´ÑÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð°Ð»ÑÑÐµÑÐ½Ð°ÑÐ¸Ð²Ð½ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð»ÐµÑÐµÐ½Ð¸Ñ. ÐÐ´Ð¸Ð½ Ð¸Ð· ÑÐ°ÐºÐ¸Ñ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² â Ð½Ð¸Ð·ÐºÐ¾ÑÐ°ÑÑÐ¾ÑÐ½Ð°Ñ ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ñ Ð¼Ð¾Ð·Ð³Ð° (ÐÐ§Ð­Ð¡). ÐÐ° Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÑÑ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ ÑÐ°Ð½ÐµÐµ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ ÐÐ§Ð­Ð¡ Ð¼Ð¾Ð¶ÐµÑ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÑÐ´Ð¾ÑÐ¾Ð¶Ð½Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ. Ð Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ð°Ð¼ ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÐÐ§Ð­Ð¡ Ð¾ÑÐ½Ð¾ÑÑÑ Ð² Ð¿ÐµÑÐ²ÑÑ Ð¾ÑÐµÑÐµÐ´Ñ Ð²ÑÑÐ¾ÐºÑÑ Ð²ÐµÑÐ¾ÑÑÐ½Ð¾ÑÑÑ Ð²Ð¾Ð·Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÑ ÑÑÑÐµÐºÑÐ¾Ð² Ð¸Ð·-Ð·Ð° Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð° Ð¼Ð¾Ð·Ð³. Ð§ÑÐ¾Ð±Ñ ÑÐ½Ð¸Ð·Ð¸ÑÑ ÑÐ¸ÑÐº Ð¿Ð¾ÑÐ²Ð»ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð±Ð¾ÑÐ½ÑÑ ÑÑÑÐµÐºÑÐ¾Ð², Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ ÑÑÐ·Ð¸ÑÑ Ð¾ÐºÐ½Ð¾ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ ÑÐ¾Ð»ÑÐºÐ¾ Ð´Ð¾ ÑÑÐ°Ð¿Ð¾Ð², ÐºÐ¾Ð³Ð´Ð° Ð¾Ð½Ð° Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð°. Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð½ÐµÐµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¾Ð±ÑÐ°ÑÐ½Ð¾Ð¹ ÑÐ²ÑÐ·Ð¸ Ð±ÑÐ»Ð¸ Ð¸Ð·ÑÑÐµÐ½Ñ ÑÑÑÐµÐºÑÑ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ Ð½Ð° ÑÐ°Ð·Ð½ÑÑ ÑÑÐ°Ð´Ð¸ÑÑ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸: Ð²Ð¾ Ð²ÑÐµÐ¼Ñ Ð¿ÑÐµÐ¸ÐºÑÐ°Ð»ÑÐ½ÑÑ ÑÐ°Ð·ÑÑÐ´Ð¾Ð² Ð¸ Ð² ÑÐ¾Ð½Ð¸ÑÐµÑÐºÑÑ ÑÐ°Ð·Ñ Ð¸ÐºÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ°Ð·ÑÑÐ´Ð°. ÐÑÐ»Ð¾ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾, ÑÑÐ¾ Ð² Ð¾ÑÐ»Ð¸ÑÐ¸Ðµ Ð¾Ñ ÐÐ§Ð­Ð¡ Ð² Ð½ÐµÐ¿ÑÐµÑÑÐ²Ð½Ð¾Ð¼ ÑÐµÐ¶Ð¸Ð¼Ðµ, Ð¿ÑÐ¸ ÑÑÐ¸Ð¼ÑÐ»ÑÑÐ¸Ð¸ ÑÐ¾Ð»ÑÐºÐ¾ Ð²Ð¾ Ð²ÑÐµÐ¼Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð½Ðµ Ð½Ð°Ð±Ð»ÑÐ´Ð°ÐµÑÑÑ ÑÐ°Ð·ÑÐµÐ¶ÐµÐ½Ð¸Ñ Ð¸ÐºÑÐ°Ð»ÑÐ½ÑÑ ÑÐ°Ð·ÑÑÐ´Ð¾Ð². ÐÐ´Ð½Ð°ÐºÐ¾ ÐÐ§Ð­Ð¡ Ð² ÑÐ¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ°Ð·Ðµ Ð¸ÐºÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ°Ð·ÑÑÐ´Ð° ÑÐ½Ð¸Ð¶Ð°ÐµÑ ÐµÐ³Ð¾ Ð´Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾ÑÑÑ.
description: Temporal lobe epilepsy is pharmacoresistant in 30% of cases, alternative treatment methods are being developed. One of such methods is the low-frequency electrical stimulation (LFES). Studies using animal models of epilepsy showed that LFES can have an anticonvulsant effect. Clinical trials indicated that LFES can have side effects due to prolonged brain stimulation. To minimize the side effects the window of stimulation has to be reduced to stages at which the stimulation is the most effective. Previously developed closed-loop system was used to study the effects of stimulation during two different stages of epileptic activity: the preictal discharges and the tonic phase of the ictal discharge. It was found that in compare to continuous LFES the stimulation during epileptic activity does not reduce the frequency of the ictal discharges. However, LFES during the tonic phase of the ictal discharge decreased its duration.