Additional file 2 of Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project
Creators: name: Camp, Robert
name: Smith, Maxwell L.
name: Larsen, Brandon T.
name: Roden, Anja C.
name: Farver, Carol
name: Moreira, Andre L.
name: Attanoos, Richard
name: Pillappa, Raghavendra
name: Sansano, Irene
name: Fabro, Alexandre Todorovic
name: Homer, Robert J.
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Additional file 2. Additional figures including screen shots of the website and graphic representation of responses to various specific questions. Fig. S1. A screen shot from the project website illustrating one of the fibrosis criteria set images with adjacent questions [13]. Above the histologic image are a series of boxed numbers. Selecting one of those boxes will select the corresponding image. The upper left-hand corner has arrows which move the viewer though the cases one at a time. The box in that corner moves the viewer back to the home page. The questions are listed on the left. In this particular example, since honeycombing is selected, the user is not asked to determine a distribution. If patchy or diffuse was selected, then that option would be available. Fig. S2. A screen shot from the project website illustrating one of the WSI with adjacent questions [13]. (A) Screen shot from the initial round. Above the histologic image are a series of four clickable slides. This shows that the case has four slides and allows navigation within the case. The upper left-hand corner has arrows which move the viewer though the slides one at a time. At the last slide, the arrow will take the viewer to the next case. The box in that corner moves the viewer back to the home page. The questions are listed on the left. Answers to questions persist across the entire case. The lower left-hand corner has vertical arrows above and below the magnification number. Magnification can be changed by clicking those arrows or by scrolling up or down within the image. The red and white pencils were designed to be used for pointing/ circling various features but were not used by participants. (B) Screen shot from the second round. This is similar to 2 A, but the first three questions have been consolidated to two. Fig. S3. Variation in evaluation of fibrosis criteria by image by pathologist. In all three figures, the left-hand side lists each image number. Specific pathologists are listed along the bottom. (A) Severity of fibrosis (severe, not severe, uncertain) (B) Pattern of fibrosis (diffuse, honeycomb only or patchy) (C) Distribution and severity of fibrosis (honeycomb, diffuse, subpleural/paraseptal, uncertain, airway centered). Fig. S4. Variation in evaluation of presence of dense inflammation away from scar (yes, no, uncertain) by image by pathologist. The left-hand side lists image number. Specific pathologists are listed along the bottom. Fig. S5. Variation in evaluation of granuloma criteria (well-formed granuloma, poorly formed granuloma, scattered giant cells only, none, uncertain) by image. The left-hand side lists image number. Specific pathologists are listed along the bottom.