cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(101854) Alfred Thomas Johnson Ward
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sialic acid-to-urea ratio as a measure of airway surface hydration
Creators: name: Hill, D.B.
name: Button, B.
name: Esther, C.R., Jr.
name: Duncan, E.A.
name: Chen, G.
name: Shi, S.
name: Doerschuk, C.M.
name: Stick, S.M.
name: Ranganathan, S.
name: Jania, C.
name: Boucher, R.C.
Publisher: name: American Physiological Society
Year: 2017

description: Although airway mucus dehydration is key to pathophysiology of cystic fibrosis (CF) and other airways diseases, measuring mucus hydration is challenging. We explored a robust method to estimate mucus hydration using sialic acid as a marker for mucin content. Terminal sialic acid residues from mucins were cleaved by acid hydrolysis from airway samples, and concentrations of sialic acid, urea, and other biomarkers were analyzed by mass spectrometry. In mucins purified from human airway epithelial (HAE), sialic acid concentrations after acid hydrolysis correlated with mucin concentrations (r2 = 0.92). Sialic acid-to-urea ratios measured from filters applied to the apical surface of cultured HAE correlated to percent solids and were elevated in samples from CF HAEs relative to controls (2.2 ± 1.1 vs. 0.93 ± 1.8, P < 0.01). Sialic acid-to-urea ratios were elevated in bronchoalveolar lavage fluid (BALF) from β-epithelial sodium channel (ENaC) transgenic mice, known to have reduced mucus hydration, and mice sensitized to house dust mite allergen. In a translational application, elevated sialic acid-to-urea ratios were measured in BALF from young children with CF who had airway infection relative to those who did not (5.5 ± 3.7 vs. 1.9 ± 1.4, P < 0.02) and could be assessed simultaneously with established biomarkers of inflammation. The sialic acid-to-urea ratio performed similarly to percent solids, the gold standard measure of mucus hydration. The method proved robust and has potential to serve as flexible techniques to assess mucin hydration, particularly in samples like BALF in which established methods such as percent solids cannot be utilized.
Reduced mucociliary clearance in old mice is associated with a decrease in muc5b mucin
Creators: name: Livraghi-Butrico, A.
name: Ostrowski, L.E.
name: Button, B.
name: Yin, W.
name: Rogers, T.D.
name: Grubb, B.R.
Publisher: name: American Physiological Society
Year: 2016

description: infections are a major cause of morbidity and mortality in the elderly. Previous reports have suggested that mucociliary clearance (MCC) is impaired in older individuals, but the cause is unclear. To unravel the mechanisms responsible for the age-associated decline in MCC, we investigated the MCC system in young (3 mo) and old (2 yr) C57BL/6 mice. We found that old mice had significantly reduced MCC function in both the upper and lower airways compared with young mice. Measurement of bioelectric properties of isolated tracheal and bronchial tissue revealed a significant decrease in Cl- secretion, suggesting that the older mice may have a reduced ability to maintain a sufficiently hydrated airway surface for efficient MCC. Ciliary beat frequency was also observed to be reduced in the older animals; however, this reduction was small relative to the reduction in MCC. Interestingly, the level of the major secreted mucin, Muc5b, was found to be reduced in both bronchioalveolar lavage and isolated tracheal tissue. Our previous studies of Muc5b-/- mice have demonstrated that Muc5b is essential for normal MCC in the mouse. Furthermore, examination of Muc5b+/- and wild-type animals revealed that heterozygous animals, which secrete ∼50% of the wild-type level of Muc5b, also demonstrate a markedly reduced level of MCC, confirming the importance of Muc5b levels to MCC. These results demonstrate that aged mice exhibit a decrease in MCC and suggest that a reduced level of secretion of both Cl- and Muc5b may be responsible.
PKC-mediated stimulation of amphibian CFTR depends on a single phosphorylation consensus site. Insertion of this site confers PKC sensitivity to human CFTR
Creators: name: Reuss, L.
name: Altenberg, G.A.
name: Button, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Mutations of the CFTR, a phosphorylation-regulated Cl- channel, cause cystic fibrosis. Activation of CFTR by PKA stimulation appears to be mediated by a complex interaction between several consensus phosphorylation sites in the regulatory domain (R domain). None of these sites has a critical role in this process. Here, we show that although endogenous phosphorylation by PKC is required for the effect of PKA on CFTR, stimulation of PKC by itself has only a minor effect on human CFTR. In contrast, CFTR from the amphibians Necturus maculosus and Xenopus laevis (XCFTR) can be activated to similar degrees by stimulation of either PKA or PKC. Furthermore, the activation of XCFTR by PKC is independent of the net charge of the R domain, and mutagenesis experiments indicate that a single site (Thr665) is required for the activation of XCFTR. Human CFTR lacks the PKC phosphorylation consensus site that includes Thr665, but insertion of an equivalent site results in a large activation upon PKC stimulation. These observations establish the presence of a novel mechanism of activation of CFTR by phosphorylation of the R domain, i.e., activation by PKC requires a single consensus phosphorylation site and is unrelated to the net charge of the R domain.
Cellulose Biomaterials for Bone Tissue Engineering
Creators: name: Leblanc Latour, Maxime
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2023
Subjects: Bone
Biomaterial
Cellulose
physics

description: Designing artificial tissue is an essential part of modern-day medicine. This is also true for bone tissue repair. Work presented in this thesis shows the steps and development of novel cellulose-based biomaterials for bone tissue engineering (BTE). Cellulose is used as the core component in these biomaterials. This work begins with an overview of the thesis, followed by a background review of the relevant biological and physical concepts. Thereafter, original research on the biomechanical properties of apple-derived cellulose are carried out in vitro and in vivo. Afterward, relevant physical forces are applied to the same type of material, to investigate the osteogenic response. Finally, cellulose nanofibrils were chemically modified to create scaffolds through UV crosslinking. These were mechanically characterized and used as scaffolds for osteogenic cell culture. As demonstrated in this work, the use of cellulose-sourced biomaterials is certainly a promising alternative compared to the industry standard. Numerous studies have demonstrated how cellulose-based biomaterials can be employed in several branches of reconstructive medicine. However, uncertainties still exist in the application of these materials for bone tissue reconstruction such as their performance under physical stress, and in their scalability. The research presented in this thesis attempts to address these gaps in knowledge. Specifically, the results presented here show how these materials can be promising candidates for low-load BTE applications. Furthermore, it is also demonstrates that mechanosensitive pathways that regulate osteogenesis remain functional on these materials. Finally, UV-curable cellulose-derived scaffolds create a more scalable and controllable biomaterial for BTE implants, notably using light-based three-dimensional printing technologies.
Switching to non-affine stochastic volatility: A closed-form expansion for the Inverse Gamma model
Creators: name: Langrené, Nicolas
name: Lee, Geoffrey
name: Zhu, Zili
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Finance (q-fin.CP)
subject: Pricing of Securities (q-fin.PR)
subject: FOS: Economics and business
subject: G.3; G.1.2; J.4
subject: 91G60, 41A58, 65C20

description: This paper introduces the Inverse Gamma (IGa) stochastic volatility model with time-dependent parameters, defined by the volatility dynamics $dV_{t}=κ_{t}\left(θ_{t}-V_{t}\right)dt+λ_{t}V_{t}dB_{t}$. This non-affine model is much more realistic than classical affine models like the Heston stochastic volatility model, even though both are as parsimonious (only four stochastic parameters). Indeed, it provides more realistic volatility distribution and volatility paths, which translate in practice into more robust calibration and better hedging accuracy, explaining its popularity among practitioners. In order to price vanilla options with IGa volatility, we propose a closed-form volatility-of-volatility expansion. Specifically, the price of a European put option with IGa volatility is approximated by a Black-Scholes price plus a weighted combination of Black-Scholes greeks, where the weights depend only on the four time-dependent parameters of the model. This closed-form pricing method allows for very fast pricing and calibration to market data. The overall quality of the approximation is very good, as shown by several calibration tests on real-world market data where expansion prices are compared favorably with Monte Carlo simulation results. This paper shows that the IGa model is as simple, more realistic, easier to implement and faster to calibrate than classical transform-based affine models. We therefore hope that the present work will foster further research on non-affine models like the Inverse Gamma stochastic volatility model, all the more so as this robust model is of great interest to the industry.
description: 30 pages, 6 figures
(101851) Philip Wathen Bush
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
Creators: name: Button, B.
name: Chen, G.
name: O'Neal, W.K.
name: Abzhanova, A.
name: Kesimer, M.
name: Sun, L.
name: Gilmore, R.C.
name: O'Neal, Y.K.
name: Deng, Y.
name: Martino, M.B.
name: Randell, S.H.
name: Batson, B.D.
name: Lin, J.M.
name: Kato, T.
name: Volmer, A.S.
name: Okuda, K.
name: Boucher, R.C.
name: Ribeiro, C.M.P.
name: Livraghi-Butrico, A.
name: Dang, H.
Publisher: name: American Society for Clinical Investigation
Year: 2019

description: Cystic fibrosis (CF) lung disease is characterized by early and persistent mucus accumulation and neutrophilic inflammation in the distal airways. Identification of the factors in CF mucopurulent secretions that perpetuate CF mucoinflammation may provide strategies for novel CF pharmacotherapies. We show that IL-1β, with IL-1α, dominated the mucin prosecretory activities of supernatants of airway mucopurulent secretions (SAMS). Like SAMS, IL-1β alone induced MUC5B and MUC5AC protein secretion and mucus hyperconcentration in CF human bronchial epithelial (HBE) cells. Mechanistically, IL-1β induced the sterile α motif-pointed domain containing ETS transcription factor (SPDEF) and downstream endoplasmic reticulum to nucleus signaling 2 (ERN2) to upregulate mucin gene expression. Increased mRNA levels of IL1B, SPDEF, and ERN2 were associated with increased MUC5B and MUC5AC expression in the distal airways of excised CF lungs. Administration of an IL-1 receptor antagonist (IL-1Ra) blocked SAMS-induced expression of mucins and proinflammatory mediators in CF HBE cells. In conclusion, IL-1α and IL-1β are upstream components of a signaling pathway, including IL-1R1 and downstream SPDEF and ERN2, that generate a positive feedback cycle capable of producing persistent mucus hyperconcentration and IL-1α and/or IL-1β-mediated neutrophilic inflammation in the absence of infection in CF airways. Targeting this pathway therapeutically may ameliorate mucus obstruction and inflammation-induced structural damage in young CF children.
A model for the erosion onset of a granular bed sheared by a viscous fluid
Creators: name: Yan, Le
name: Barizien, Antoine
name: Wyart, Matthieu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study theoretically the erosion threshold of a granular bed forced by a viscous fluid. We first introduce a novel model of interacting particles driven on a rough substrate. It predicts a continuous transition at some threshold forcing $θ_c$, beyond which the particle current grows linearly $J\sim θ-θ_c$, in agreement with experiments. The stationary state is reached after a transient time $t_{\rm conv}$ which diverges near the transition as $t_{\rm conv}\sim |θ-θ_c|^{-z}$ with $z\approx 2.5$. The model also makes quantitative testable predictions for the drainage pattern: the distribution $P(σ)$ of local current is found to be extremely broad with $P(σ)\sim J/σ$, spatial correlations for the current are negligible in the direction transverse to forcing, but long-range parallel to it. We explain some of these features using a scaling argument and a mean-field approximation that builds an analogy with $q$-models. We discuss the relationship between our erosion model and models for the depinning transition of vortex lattices in dirty superconductors, where our results may also apply.
description: 5 pages, 6 figures
title: Tuberous sclerosis: A pictorial review from head to feet.
Creators: name: González Delgado, Cristina
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Education
subject: MR
subject: CT
subject: Paediatric
subject: Neuroradiology brain
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the characteristic multimodality imaging findings of tuberous sclerosis...
تاريخ وهوية جامعة الملكة أروى على الإنترنت ومراحل التطوير منذ العام 1998 - 2021 م.pdf
Creators: name: Al-Slfi, Saddam
Publisher: name: figshare
Year: 2023
Subjects: Organisation of information and knowledge resources
Open access
Digital curation and preservation

description: تأسست جامعة الملكة أروى ومارست نشاطها التعليمي منذ مطلع العام 1996 م واستقبلت العديد من الطلبة وأعضاء هيئة التدريس المحليين والدوليين وشكلت احدى اهم مؤسسات التعليم العالي الأهلي في تلك الحقبة وضمن أنشطه الطلاب والتطبيق العملي للمواد الدراسية قام مجموعة من الطلاب بإنشاء اول موقع إلكتروني وكان يهتم بالتعريف عن الجامعة وأخبارها واهم كلياتها وأقسامها والعديد من الخدمات التي نراها بدائية في وقتنا الحاضر الا انها كانت مشروع ناجح نال إعجاب الجميع ، وعندما علمت الدكتورة وهيبة فارع رئيس مجلس أمناء الجامعة بالأمر اشرفت بنفسها وبشكل مباشر على مراحل تصميم وبرمجة موقع جامعة الملكة أروى وتكريماً لهؤلاء الطلبة اعتمدت رئاسة الجامعة المشروع كموقع رسمي يمثل نشاط جامعة الملكة على الشبكة العنكبوتية وتم العمل رسمياً بالموقع ونشرة على الإنترنت من مطلع العام 1998 م وكانت اول جامعة يمنية تطلق موقعها الالكتروني على شبكة الإنترنت وحصلت على تقييم جيد وعضويه لدى منظمة اليونسكو للتعليم في حينها.
title: Abdominal CT Findings In Patients with Primary Lymphoma Causing Small Bowel Obstruction
Creators: name: ERBAY, GÜRCAN
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Haematologic diseases
subject: Diagnostic procedure
subject: CT
subject: Oncology
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Primary gastrointestinal (GI) lymphoma is rarely seen, constituting 1–4% of all malignancies which affect the GI tract. The most common affected regions are stomach (50–70%), small bowel (20–35%), colon (frequently the cecum) (5–10%), and...
title: Using Clinic Hypnosis (CH) in a Radiology Department; a preliminary experience.
Creators: name: Cossa, Stefano
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Management
subject: Experimental
subject: Efficacy studies
subject: Sedation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of our work has been to develop a therapeutic diagnostic path where Imaging interacts with the Clinical Hypnosis (CH). In a Diagnostic Imaging department, a wide spectrum of instrumental techniques and microinvasive procedures are usually...
title: MDCT capabilities in accessment of chronic toxic kidney parenchymal damage in patients with alcohol surrogate abuses
Creators: name: Kokunin, Alexey
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Toxicity
subject: Pathology
subject: Contrast agent-intravenous
subject: CT
subject: Kidney
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to: 1. Describe and illustrate the MDCT imaging findings of kidney parenchymal changes in patients with alcohol surrogate abuses; 2. Provide relevant data on the pathomorphology and clinical manifestations...
title: Differences between lead point and non-lead point intussusception with CT in adults: significant impact on patient management
Creators: name: Gutierrez Martinez, Beatriz
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Education
subject: CT
subject: Colon
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: -To describe clinical and pathophysiological differences between adult intussusception without and with associated intussusception head, both in small and large intestine. -To describe advantages of CT as a diagnostic tool and illustrate...
The effect of cultural, familial, and socioeconomic factors on Asian American help seeking attitudes compared to White Americans
Creators: name: Nguyen, Luke
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Past research has shown that Asian Americans (AAs) have low levels of help-seeking behavior for mental health and higher levels of mental illness than the national US average. In order to better understand why AAs display low levels of these help-seeking behaviors, this study investigates how acculturation, family conflict, and socioeconomic status (SES) associate with help-seeking attitudes in AAs relative to White Americans (WA), who served as the control group. Based on existing literature, researchers hypothesized that low acculturation, high family conflict, and low SES would be negatively associated with lower help-seeking attitudes in the AA group compared to the WA group. A sample of 491 college students (237 AA, 254 WA) were asked to complete a survey measuring the specified variables listed above. Results demonstrate that race has a significant effect on help-seeking attitudes, with AAs having lower help-seeking attitudes than WAs. Acculturation, family conflict, and SES had no correlation with help seeking attitudes in the AA group. On the other hand, in the WA group there was a negative correlation between family conflict and help-seeking attitudes. Being AA was significantly associated with lower help seeking attitudes and higher family conflict than in the WA group. Future directions for research about AA help seeking include investigating the relationship between coping strategies and help seeking attitudes, as well as comparing differences between AA subgroups instead of using a WA control group.
title: Common errors in head and neck imaging and how to avoid them.
Creators: name: Barón Ródiz, Paola
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Head and neck
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Image compression
subject: Perception image
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: We propose to attend these objectives: Review the importance of radiological error and its classification system. Present and discuss some common sources of misinterpretation in head and neck imaging. Suggest strategies for error...
(101852) Francis William Ward
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
data for Numerical Investigation of the Evolution Dynamics of Irregular Fresh Groundwater Lensesin Offshore Reclaimed Islands
Creators: name: gao, chenchen
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 370703
subject: Groundwater hydrology

description: data for Numerical Investigation of the Evolution Dynamics of Irregular Fresh Groundwater Lensesin Offshore Reclaimed Islands
Molecule sublimation as a tracer of protostellar accretion: Evidence for accretion bursts from high angular resolution C18O images
Creators: name: Jorgensen, Jes K.
name: Visser, Ruud
name: Williams, Jonathan P.
name: Bergin, Edwin A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The accretion histories of embedded protostars are an integral part of descriptions of their physical and chemical evolution. In particular, are the accretion rates smoothly declining from the earlier toward later stages or in fact characterized by variations such as intermittent bursts? We aim to characterize the impact of possible accretion variations in a sample of embedded protostars by measuring the size of the inner regions of their envelopes where CO is sublimated and relate those to their temperature profiles dictated by their current luminosities. Using observations from the Submillimeter Array we measure the extents of the emission from the C18O isotopologue toward 16 deeply embedded protostars. We compare these measurements to the predicted extent of the emission given the current luminosities of the sources through dust and line radiative transfer calculations. Eight out of sixteen sources show more extended C18O emission than predicted by the models. The modeling shows that the likely culprit for these signatures is sublimation due to increases in luminosities of the sources by about a factor five or more during the recent 10,000 years - the time it takes for CO to freeze-out again on dust grains. For four of those sources the increase would have had to have been a factor 10 or more. The compact emission seen toward the other half of the sample suggests that C18O only sublimates when the temperature exceeds 30 K - as one would expect if CO is mixed with H2O in the grain ice-mantles. The small-number statistics from this survey suggest that protostars undergo significant bursts about once every 20,000 years. This also illustrates the importance of taking the physical evolutionary histories into account for descriptions of the chemical structures of embedded protostars.
description: Accepted by A&A; 11 pages, 5 figures
KamLAND Sensitivity to Neutrinos from Pre-Supernova Stars
Creators: name: Asakura, K.
name: Gando, A.
name: Gando, Y.
name: Hachiya, T.
name: Hayashida, S.
name: Ikeda, H.
name: Inoue, K.
name: Ishidoshiro, K.
name: Ishikawa, T.
name: Ishio, S.
name: Koga, M.
name: Matsuda, S.
name: Mitsui, T.
name: Motoki, D.
name: Nakamura, K.
name: Obara, S.
name: Oura, T.
name: Shimizu, I.
name: Shirahata, Y.
name: Shirai, J.
name: Suzuki, A.
name: Tachibana, H.
name: Tamae, K.
name: Ueshima, K.
name: Watanabe, H.
name: Xu, B. D.
name: Kozlov, A.
name: Takemoto, Y.
name: Yoshida, S.
name: Fushimi, K.
name: Piepke, A.
name: Banks, T. I.
name: Berger, B. E.
name: Fujikawa, B. K.
name: O'Donnell, T.
name: Learned, J. G.
name: Maricic, J.
name: Matsuno, S.
name: Sakai, M.
name: Winslow, L. A.
name: Efremenko, Y.
name: Karwowski, H. J.
name: Markoff, D. M.
name: Tornow, W.
name: Detwiler, J. A.
name: Enomoto, S.
name: Decowski, M. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: In the late stages of nuclear burning for massive stars ($M>8~M_{\sun}$), the production of neutrino-antineutrino pairs through various processes becomes the dominant stellar cooling mechanism. As the star evolves, the energy of these neutrinos increases and in the days preceding the supernova a significant fraction of emitted electron anti-neutrinos exceeds the energy threshold for inverse beta decay on free hydrogen. This is the golden channel for liquid scintillator detectors because the coincidence signature allows for significant reductions in background signals. We find that the kiloton-scale liquid scintillator detector KamLAND can detect these pre-supernova neutrinos from a star with a mass of $25~M_{\sun}$ at a distance less than 690~pc with 3$σ$ significance before the supernova. This limit is dependent on the neutrino mass ordering and background levels. KamLAND takes data continuously and can provide a supernova alert to the community.
description: 19 pages, 6 figures, 1 table
title: Comparison of image quality and radiation dose between conventional 2D full field digital mammography and synthetic 2D mammography
Creators: name: Dam-Vervloet, Lida
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Physics
subject: Equipment
subject: Acceptance testing
subject: Mammography
subject: Radioprotection / Radiation dose
subject: Breast
subject: Quality assurance
subject: Image verification

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Digital breast tomosynthesis vendors have introduced synthetic 2D mammograms, reconstructed from digital breast tomosynthesis projections. These synthetic 2D mammograms were introduced to replace conventional 2D full field digital mammography...
(101853) John Frederick Lucas
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance
Creators: name: Bhat, Virunya S.
name: Meek, M.E.
name: Valcke, Mathieu
name: English, Caroline
name: Boobis, Alan
name: Brown, Richard
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: The application of chemical-specific toxicokinetic or toxicodynamic data to address interspecies differences and human variability in the quantification of hazard has potential to reduce uncertainty and better characterize variability compared with the use of traditional default or categorically-based uncertainty factors. The present review summarizes the state-of-the-science since the introduction of the World Health Organization/International Programme on Chemical Safety (WHO/IPCS) guidance on chemical-specific adjustment factors (CSAF) in 2005 and the availability of recent applicable guidance including the WHO/IPCS guidance on physiologically-based pharmacokinetic (PBPK) modeling in 2010 as well as the U.S. EPA guidance on data-derived extrapolation factors in 2014. A summary of lessons learned from an analysis of more than 100 case studies from global regulators or published literature illustrates the utility and evolution of CSAF in regulatory decisions. Challenges in CSAF development related to the adequacy of, or confidence in, the supporting data, including verification or validation of PBPK models. The analysis also identified issues related to adequacy of CSAF documentation, such as inconsistent terminology and often limited and/or inconsistent reporting, of both supporting data and/or risk assessment context. Based on this analysis, recommendations for standardized terminology, documentation and relevant interdisciplinary research and engagement are included to facilitate the continuing evolution of CSAF development and guidance.
title: Morphology of vessel occlusion at digital subtraction angiography predicts response to endovascular treatment.
Creators: name: Haglmueller, Thomas Alois
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Neuroradiology brain
subject: Arteries / Aorta
subject: Catheter arteriography
subject: Thrombolysis
subject: Intraoperative
subject: Catheters
subject: Ischaemia / Infarction
subject: Embolism / Thrombosis
subject: Acute

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Recent trials established the clinical benefit of endovascular treatment for acute ischemic stroke patients affected by emergent large vessel occlusion (ELVO) [1-5]. Beside the more popular stent-assisted technique, direct aspiration thrombectomy...
Additional file 1 of A silent strain: the unseen burden of acute respiratory infections in children
Creators: name: Boracchini, Riccardo
name: Canova, Benedetta
name: Ferrara, Pietro
name: Cantarutti, Luigi
name: Giaquinto, Carlo
name: Di Chiara, Costanza
name: Cantarutti, Anna
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 1.
title: Lumbosacral Transitional Vertebrae: A diagnostic challenge by MRI. The value of MDCT and conventional radiograph in the definitive diagnosis.
Creators: name: Rodríguez Eiriz, Maria
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Normal variants
subject: Education
subject: Computer Applications-3D
subject: MR
subject: CT
subject: Conventional radiography
subject: Neuroradiology spine
subject: Bones
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To highlight the importance of identifying lumbosacral transitional vertebrae (LSTV) by MRI. To demonstrate the usefulness of multidetector computer tomography (MDCT) in the definitive diagnosis of LSTV. To explain Castellvi´s method as the...
(101855) Clara Lucas
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Joseph ideals and lisse minimal W-algebras
Creators: name: Arakawa, Tomoyuki
name: Moreau, Anne
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: Mathematical Physics (math-ph)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider a lifting of Joseph ideals for the minimal nilpotent orbit closure to the setting of affine Kac-Moody algebras and find new examples of affine vertex algebras whose associated varieties are minimal nilpotent orbit closures. As an application we obtain a new family of lisse ($C_2$-cofinite) W-algebras that are not coming from admissible representations of affine Kac-Moody algebras.
description: References and comments added in the introduction. Proof of Theorem 4.2 slightly correct. Conjecture 2 and 4 are corrected
The Ties That Bind: Surrogate Representation in the United States House of Representatives
Creators: name: Steelman, Tyler
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: In a 2015 interview with the Minnesota Post, U.S. House member Keith Ellison made the
      startling comment that he “. . . didn’t run for Congress to talk about my religion all the
      time. . . ”; instead he ran “. . . to increase the minimum wage, strengthen the right to bargain
      collectively, to do something about climate change, to help students afford college.”
      What is being described is surrogate representation—an often understudied phenomenon
      in theories of American representation—which is the link between a legislator and citizen
      where no formal electoral, and territorial, connection exists. Using an original method to
      identify the location of donors to members of the United States House of Representatives
      in 2016 I demonstrate the surrogate legislators have a higher percentage of their constituencies
      originating from outside their geographic district. This process is facilitated by speciail
      interested organizations, like EMILY’s List which can increase a surrogate legislator’s
      out-of-district constitueny even further. Surrogate legislators are attracting the attention of
      citizens across political boundaries and are seeing significant increases to the percentage
      of their campaign contributions that are coming from outside their congressional district,
      as a result. In effect, these legislators are redefining their constituencies to include both
      in-district and out-of-district citizens.
Topological septet pairing with spin-$\frac{3}{2}$ fermions -- high partial-wave channel counterpart of the $^3$He-B phase
Creators: name: Yang, Wang
name: Li, Yi
name: Wu, Congjun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We systematically generalize the exotic $^3$He-B phase, which not only exhibits unconventional symmetry but is also isotropic and topologically non-trivial, to arbitrary partial-wave channels with multi-component fermions. The concrete example with four-component fermions is illustrated including the isotropic $f$, $p$ and $d$-wave pairings in the spin septet, triplet, and quintet channels, respectively. The odd partial-wave channel pairings are topologically non-trivial, while pairings in even partial-wave channels are topologically trivial. The topological index reaches the largest value of $N^2$ in the $p$-wave channel ($N$ is half of the fermion component number). The surface spectra exhibit multiple linear and even high order Dirac cones. Applications to multi-orbital condensed matter systems and multi-component ultra-cold large spin fermion systems are discussed.
(101848) Thomas Slack
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Deriving a Risk-Based Breast Density Classification Scale for Population-Level Screening Using FFDM
Creators: name: Iles, Sian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Technology assessment
subject: Statistics
subject: Computer Applications-General
subject: Mammography
subject: Digital radiography
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Percent mammographic density (MD), measured as the proportion of fibrous and glandular tissue within the breast tissue area on a mammogram, is a risk factor for breast cancer and is also associated with a number of known breast cancer risk factors...
(101850) Ellen J Ward
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
THE INFLUENCE OF A FATIGUE-INDUCING ACUTE BOUT OF EXERCISE ON LANDING BIOMECHANICS AND MARKERS OF MUSCLE STRESS
Creators: name: Hawley, Victoria
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: PURPOSE: To determine the effect of an acute bout of high-intensity exercise on 3D landing biomechanics (sagittal plane knee angle, frontal plane knee angle, sagittal plane hip angle, frontal plane hip angle, vGRF) and creatine kinase release 30 minutes and 24 hours after an acute bout of high-intensity exercise. A secondary purpose was to determine the relationship between landing biomechanics and creatine kinase release at baseline, 30 minutes and 24 hours after an acute bout of high-intensity exercise.
      METHODS: Twenty subjects completed a speed-only VO2submax test to determine the ventilatory threshold (VT). Subjects then completed 5 bouts of running at VT for 5 minutes, 10 jump landings, and 10 split squats, followed by 2 rounds of 10 jump landings and 20 split squats. A blood draw and 3D biomechanical analysis were completed pre-fatigue, 30 minutes post-fatigue, and 24 hours post-fatigue. One-way within-subjects ANOVAs were used to determine the effect of an acute bout of fatiguing exercise on landing biomechanics and creatine kinase release pre-fatigue, 30 minutes post-fatigue, and 24 hours post-fatigue. A multiple regression was employed to determine the relationship between creatine kinase release and landing biomechanics pre-fatigue, 30 minutes post-fatigue, and 24 hours post-fatigue.
      RESULTS: Knee sagittal Euler angle and knee frontal world angle at initial contact significantly decreased from Pre- to Post-30 (p=0.000 and p=0.008, respectively). Knee frontal world angle at initial contact significantly decreased from pre- to post-24 (p=0.015). CK significantly increased from Pre- to Post-30 (p=0.000), Pre- to Post-24 (p=0.000), and Post-30 to Post-24 (p=0.033). There were significant relationships between baseline vGRF and %change in CK from Pre- to Post-24 (r= -0.518, p= 0.028), baseline vGRF and baseline maximal knee sagittal angle (r= -0.518, p=0.019), and baseline vGRF and baseline minimal hip sagittal angle (r= 0.555, p=0.011).
      CONCLUSION: An acute bout of fatigue-inducing exercise increases knee valgus and decreases knee flexion at initial contact and increases CK immediately after and 24 hours after exercise, with peak values occurring at 24 hours after exercise. Increased vGRF is associated with less hip and knee flexion, and subsequently less CK release.
title: Technical evaluation of six FUJI Amulet s Digital Breast Imaging Systems
Creators: name: Gershan, Vesna
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Quality assurance
subject: Technology assessment
subject: Mammography
subject: Radiation physics
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Six FUJI Amulet s digital mammography systems were installed in six city hospitals around the country between November 2015 and January 2016. Since these systems were a new brand in the country, it was decided to perform technical performances...
(101846) Margery Rhoda Younger
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
On a conjecture of Kuznetsov and Polishchuk
Creators: name: Fonarev, Anton
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We prove a conjecture by A. Kuznetsov and A. Polishchuk on the existence of some particular full exceptional collections in bounded derived categories of coherent sheaves on Grassmannian varieties.
description: 15 pages, 4 TikZ figures
CELL TYPE AND TISSUE SPECIFIC FUNCTIONS OF CD73
Creators: name: Minor, Marquet
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: CD73 is a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate (AMP) to adenosine. CD73 couples closely with ecto-apyrase (CD39), which supplies the AMP substrate via sequential dephosphorylation of extracellular ATP. CD73-generated adenosine functions in an autocrine and paracrine manner to control numerous physiological responses by activating one of four subtypes of G-protein-coupled adenosine receptors: A1R, A2AR, A2BR, and A3R.  Missense mutations in the CD73-encoding gene NT5E cause the rare, adult-onset vascular disease named ‘arterial calcifications due to deficiency of CD73’ (ACDC). Aside from direct human disease involvement, cellular and animal model studies have revealed key functions of CD73 in tissue homeostasis and pathophysiologic responses in the cardiovascular and central nervous system, as well as epithelial tissues, including the lung, kidney and liver. This review covers CD73 functions in multiple organ systems, with a focus on novel findings from the last 3-5 years.
title: When does a benign focal hepatic lesion undergo surgical resection? The image is on the case.
Creators: name: Rodríguez Eiriz, Maria
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Surgery
subject: Imaging sequences
subject: Contrast agent-intravenous
subject: MR
subject: CT
subject: Management
subject: Liver
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review patients who underwent a liver resection for a benign focal hepatic lesion in our hospital between 2010 and 2015. To describe their imaging features. To identify the indications for the...
title: MRI evaluation of perianal fistulae: comparison of post contrast T1WI and Fat-suppressed T2WI
Creators: name: Alkubeyyer, Metab
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Pelvis
subject: MR
subject: Diagnostic procedure
subject: Fistula

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Magnetic resonance imaging (MRI) is one of the best imaging modalities for assessment of patients with anal fistula. MRI accurately demonstrate disease extension andcan help identify infected tracts and abscesses that would otherwise have been...