cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Soft-gluon corrections for $tqZ$ production
Creators: name: Kidonakis, Nikolaos
name: Yamanaka, Nodoka
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study soft-gluon corrections for the associated production of a single top quark and a $Z$ boson ($tqZ$ production) at hadron colliders. We find that the radiative corrections are dominated by soft-gluon emission. We calculate the approximate NNLO (aNNLO) cross section at LHC energies, including uncertainties from scale dependence and from parton distributions. We also calculate differential distributions in top-quark rapidity. We show that the aNNLO corrections are significant and they enhance the NLO cross section while decreasing theoretical uncertainties.
description: 10 pages, 4 figures
Transformative Social and Emotional Learning and Teacher Praxis
Creators: name: Borowski, Teresa G
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Transformative social and emotional learning (SEL) is a process in which students and teachers build strong, respectful relationships founded on an appreciation of similarities and differences, learn to critically examine the causes of inequity, and develop collaborative solutions to community and societal problems (Jagers et al., 2018). The language of transformative SEL may be novel, yet it can be advantageous to look to practice and see how teachers – who play a significant role in the implementation of SEL programs (Jones et al., 2013) – may already be leveraging SEL in service of equity. Five middle-school teachers who implemented a cultural dance and SEL program during the 2020-2021 school year participated in two interviews before and after implementation. Data from interviews were coded and analyzed using qualitative thematic analysis (Braun & Clark, 2006). The results of the study highlight the interconnectedness of SEL and equitable approaches in education. In teachers’ descriptions of SEL, they often discussed the importance of openness, nonjudgement, and advocacy. Acceptance and appreciation of differences permeated discussions of both SEL and equity. Teachers provided students with varied avenues to success, as well as expanded content knowledge to both expose students to new things and to relate to students’ lived experiences. Teachers practiced transformative SEL in many ways: teachers were intentional, transparent, provided opportunities for students’ voice and choice, and communicated care to their students. Further, teachers’ mindsets recognized students as individuals with whom to create unique relationships and viewed students in a positive light. These mindsets and practices provided a foundation for authentic relationships and important dialogue in the classroom. Findings from this study can inform the development of pre-service and in-service teacher training, curricula and programming, and future research.
The role of enzyme replacement therapy in severe Hunter syndrome—an expert panel consensus
Creators: name: Harmatz, Paul
name: Muenzer, Joseph
name: Frenking, Gudrun Schulze
name: Jones, Simon
name: Rojas, Maria Verónica Muñoz
name: Bodamer, Olaf
name: Beck, Michael
name: Burton, Barbara
name: Scarpa, Maurizio
name: Clarke, Lorne
name: Giugliani, Roberto
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Intravenous enzyme replacement therapy (ERT) with idursulfase for Hunter syndrome has not been demonstrated to and is not predicted to cross the blood–brain barrier. Nearly all published experience with ERT with idursulfase has therefore been in patients without cognitive impairment (attenuated phenotype). Little formal guidance is available on the issues surrounding ERT in cognitively impaired patients with the severe phenotype. An expert panel was therefore convened to provide guidance on these issues. The clinical experience of the panel with 66 patients suggests that somatic improvements (e.g., reduction in liver volume, increased mobility, and reduction in frequency of respiratory infections) may occur in most severe patients. Cognitive benefits have not been seen. It was agreed that, in general, severe patients are candidates for at least a 6–12-month trial of ERT, excluding patients who are severely neurologically impaired, those in a vegetative state, or those who have a condition that may lead to near-term death. It is imperative that the treating physician discuss the goals of treatment, methods of assessment of response, and criteria for discontinuation of treatment with the family before ERT is initiated. Conclusion: The decision to initiate ERT in severe Hunter syndrome should be made by the physician and parents and must be based on realistic expectations of benefits and risks, with the understanding that ERT may be withdrawn in the absence of demonstrable benefits.
No Cosmic Rays from Curvature Oscillations during Structure Formation with $F(R)$-gravity
Creators: name: Gorbunov, Dmitry
name: Tokareva, Anna
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Starobinsky model of modified gravity suggested to explain dark energy may be also considered in the astrophysical context. Recently it has been pointed out that in contracting regions curvature oscillations around the GR value may lead to the production of high energy particles which contribute to the cosmic ray flux. We revisit these calculations in the Einstein frame and show that the continuous approximation for the matter density used in the original calculations is not valid. We show that this problem is generic in $F(R)$-gravity models introduced to describe the dark energy. We go beyond the approximation and find the rate of particle production to be negligible.
description: 9 pages; v2: replaced with revised version; v3: extended discussion, new appendix with 3 figures added, journal version
Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization
Creators: name: Mumper, Russell J.
name: Dong, Xiaowei
name: Adams, Val R.
name: Tseng, Michael
name: Mattingly, Cynthia A.
name: Cho, Moo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The objective of these studies was to develop Cremophor-free lipid-based paclitaxel (PX) nanoparticle formulations prepared from warm microemulsion precursors. To identify and optimize new nanoparticles, experimental design was performed combining Taguchi array and sequential simplex optimization. The combination of Taguchi array and sequential simplex optimization efficiently directed the design of paclitaxel nanoparticles. Two optimized paclitaxel nanoparticles (NPs) were obtained: G78 NPs composed of glyceryl tridodecanoate (GT) and polyoxyethylene 20-stearyl ether (Brij 78), and BTM NPs composed of Miglyol 812, Brij 78 and D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). Both nanoparticles successfully entrapped paclitaxel at a final concentration of 150 μg/ml (over 6% drug loading) with particle sizes less than 200 nm and over 85% of entrapment efficiency. These novel paclitaxel nanoparticles were stable at 4°C over three months and in PBS at 37°C over 102 hours as measured by physical stability. Release of paclitaxel was slow and sustained without initial burst release. Cytotoxicity studies in MDA-MB-231 cancer cells showed that both nanoparticles have similar anticancer activities compared to Taxol®. Interestingly, PX BTM nanocapsules could be lyophilized without cryoprotectants. The lyophilized powder comprised only of PX BTM NPs in water could be rapidly rehydrated with complete retention of original physicochemical properties, in-vitro release properties, and cytotoxicity profile. Sequential Simplex Optimization has been utilized to identify promising new lipid-based paclitaxel nanoparticles having useful attributes.
Quantum Algorithms for Geologic Fracture Networks
Creators: name: Henderson, Jessie M.
name: Podzorova, Marianna
name: Cerezo, M.
name: Golden, John K.
name: Gleyzer, Leonard
name: Viswanathan, Hari S.
name: O'Malley, Daniel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Solving large systems of equations is a challenge for modeling natural phenomena, such as simulating subsurface flow. To avoid systems that are intractable on current computers, it is often necessary to neglect information at small scales, an approach known as coarse-graining. For many practical applications, such as flow in porous, homogenous materials, coarse-graining offers a sufficiently-accurate approximation of the solution. Unfortunately, fractured systems cannot be accurately coarse-grained, as critical network topology exists at the smallest scales, including topology that can push the network across a percolation threshold. Therefore, new techniques are necessary to accurately model important fracture systems. Quantum algorithms for solving linear systems offer a theoretically-exponential improvement over their classical counterparts, and in this work we introduce two quantum algorithms for fractured flow. The first algorithm, designed for future quantum computers which operate without error, has enormous potential, but we demonstrate that current hardware is too noisy for adequate performance. The second algorithm, designed to be noise resilient, already performs well for problems of small to medium size (order 10 to 1000 nodes), which we demonstrate experimentally and explain theoretically. We expect further improvements by leveraging quantum error mitigation and preconditioning.
description: 20 pages, 12 figures
Lipid nanocapsule as vaccine carriers for his-tagged proteins: Evaluation of antigen-specific immune responses to HIV I His-Gag p41 and systemic inflammatory responses
Creators: name: Woodward, Jerold G.
name: Wadhwa, Saurabh
name: Mumper, Russell J.
name: Jain, Anekant
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The purpose of this study was to design novel nanocapsules (NCs) with surface-chelated nickel (Ni-NCs) as a vaccine delivery system for histidine (His)-tagged protein antigens. Ni-NCs were characterized for binding His-tagged model proteins through high affinity non-covalent interactions. The mean diameter and zeta potential of the optimized Ni-NCs was 214.9 nm and - 14.8 mV, respectively. The optimal binding ratio of His-tagged Green Fluorescent Protein (His-GFP) and His-tagged HIV-1 Gag p41 (His-Gag p41) to the Ni-NCs was 1:221 and 1:480 w/w, respectively. Treatment of DC2.4 cells with Ni-NCs did not result in significant loss in the cell viability up to 24 h (
Enhanced single photon emission from positioned InP/GaInP quantum dots coupled to a confined Tamm-plasmon mode
Creators: name: Braun, T.
name: Baumann, V.
name: Iff, O.
name: Höfling, S.
name: Schneider, C.
name: Kamp, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report on the enhancement of the spontaneous emission in the visible red spectral range from site-controlled InP/GaInP quantum dots by resonant coupling to Tammplasmon modes confined beneath gold disks in a hybrid metal/semiconductor structure. The enhancement of the emission intensity is confirmed by spatially resolved microphotoluminescence area scans and temperature dependent measurements. Single photon emission from our coupled system is verified via second order autocorrelation measurements. We observe bright single quantum dot emission of up to ~173000 detected photons per second at a repetition rate of the excitation source of 82 MHz, and calculate an extraction efficiency of our device as high as 7%.
Unveiling the Markovian to non-Markovian transition with quantum collision models
Creators: name: Magalhães, Willames F.
name: Neto, Carlos O. A. Ribeiro
name: Bernardo, Bertúlio de Lima
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The concept of non-Markovianity in open quantum systems is traditionally associated with the existence of information backflows from the environment to the system. Meanwhile, the mechanisms through which such backflows emerge are still a subject of debate. In this work, we use collision models to study memory effects in the dynamics of a qubit system in contact with a thermal bath made up of few ancillas, in which system-ancilla and ancilla-ancilla interactions are considered. In the single-ancilla limit case, we show that the system-bath information flow exhibits an interesting mixture of chaotic and regular oscillatory behavior, which depends on the interaction probabilities. In parallel, our results clearly indicate that the information backflows decrease when new ancillas are added to the bath, which sheds light on the nature of the Markovian to non-Markovian transition.
description: 24 pages, 8 figures
Families of Juvenile with Life Sentence: Advocacy and Support in a Changing Policy Landscape
Creators: name: Yang, Zixiaojie
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Recent policy trends in the juvenile justice system emphasize distinguishing juveniles from adults and focused on severe punishment. Although numerous studies have highlighted the impact of harsh punishment and incarceration on families, current research has largely failed to document the experience of families of individuals with a juvenile life without parole sentence (JLWOP). My dissertation explored how families of juvenile lifers cope with juvenile incarceration and the evolving policy landscape and how and why families engage in system reform efforts. I examined my research questions using a case study methodology with a qualitative approach. Nine participants were recruited from a mutual aid community-based group whose members are the families of individuals with a JLWOP. The inquiry was guided by the radical healing and mutual aid frameworks. Each participant was interviewed twice to gather their experience interacting with the justice system and their participation in the advocacy work. In addition, field observation took place in the group activities, including monthly meetings, online training, and advocacy events. The documents related to participants' loved ones' cases and local political efforts were reviewed. Data were analyzed with deductive coding guided by the conceptual frameworks and inductive coding guided by Braun and Clarke's (2006) thematic analysis framework. The results highlighted the social toxins around families of incarcerated people, the unique role of community building and the mutual aid group, and the process of radical healing as family members develop critical consciousness and engage in civic actions. As a group, families were able to identify how the justice system established barriers purposefully in preventing incarcerated people from receiving social support and the steps they can take to make a political change. As a result, families gain power and control of their life situations and acquire tools to resist systematic oppression. This study filled the research gap on the impact of long-term incarceration on families. It also identified the role of community organizing and mutual aid groups for a marginalized population and discussed mutual aid groups as a potential intervention. Last but not least, my dissertation showcased the importance of directly impacted individuals in leading social justice efforts.
SCH-23390 antagonism of a D-2 dopamine agonist depends upon catecholaminergic neurons
Creators: name: Mueller, Robert A.
name: Breese, George R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: SCH-23390, a selective D-1 dopamine antagonist, was found to antagonize the locomotor stimulation induced by LY-171555, an action similar to that for haloperidol in control animals. However, this action of SCH-23390 was prevented in rats treated with 6-hydroxydopamine (6-OHDA) or with reserpine plus α-methyl-tyrosine pretreatment. These results indicate that the action of SCH-23390 to antagonize D-2 dopamine receptor actions is dependent upon functional catecholamine-containing neurons. In contrast to the lack of action of SCH-23390 to antagonize LY-171555 in 6-OHDA-treated rats, SCH-23390 blocked the locomotor stimulation induced by SKF-39393, a D-1 dopamine agonist, after this treatment. Thus, D-1 dopamine receptors are distinct from D-2 receptor sites and can exhibit a behavior similar to that observed when D-2 receptors are stimulated. These data suggest that D-1 receptor sites modulate D-2 dopamine receptor function through a mechanism dependent upon functionally intact catecholamine-containing neurons.
Odd graph and its applications to the strong edge coloring
Creators: name: Wang, Tao
name: Zhao, Xiaodan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Discrete Mathematics (cs.DM)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 05C15

description: A strong edge coloring of a graph is a proper edge coloring in which every color class is an induced matching. The strong chromatic index $χ_s'(G)$ of a graph $G$ is the minimum number of colors in a strong edge coloring of $G$. Let $Δ\geq 4$ be an integer. In this note, we study the odd graphs and show the existence of some special walks. By using these results and Chang's ideas in [Discuss. Math. Graph Theory 34 (4) (2014) 723--733], we show that every planar graph with maximum degree at most $Δ$ and girth at least $10 Δ- 4$ has a strong edge coloring with $2Δ- 1$ colors. In addition, we prove that if $G$ is a graph with girth at least $2Δ- 1$ and mad$(G) < 2 + \frac{1}{3Δ- 2}$, where $Δ$ is the maximum degree and $Δ\geq 4$, then $χ_s'(G) \leq 2Δ- 1$, if $G$ is a subcubic graph with girth at least $8$ and mad$(G) < 2 + \frac{2}{23}$, then $χ_s'(G) \leq 5$.
description: 7 pages
Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol
Creators: name: Kelley, Stephen P.
name: Krishnan, Kathiresan
name: Leslie Morrow, A.
name: Mennerick, Steven
name: Covey, Douglas F.
name: Alan, Jamie K.
name: O'Buckley, Todd K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Endogenous pregnane neurosteroids are allosteric modulators at γ-aminobutyric acid type-A (GABAA) receptors at nanomolar concentrations. There is direct evidence for multiple distinct neurosteroid binding sites on GABAA receptors, dependent upon subunit composition and stoichiometry. This view is supported by the biphasic kinetics of various neuroactive steroids, enantioselectivity of some neurosteroids, selective mutation studies of recombinantly expressed receptors and the selectivity of the neurosteroid antagonist (3α,5α)-17-phenylandrost-16-en-3-ol (17PA) on 5α-pregnane steroid effects on recombinant GABAA receptors expressed in Xenopus oocytes and native receptors in dissociated neurons. However, it is unclear whether this antagonist action is present in a mature mammalian system. The present study evaluated the antagonist activity of 17PA on neurosteroid agonists both in vivo and in vitro by examining the effects of 17PA on 5α-pregnane-induced sedation in rats, native mature GABAA receptor ion channels utilizing the chloride flux assay and further studies in recombinant α1β2γ2 receptors. The data show that 17PA preferentially inhibits 3α,5α-THP vs. alphaxalone in vivo, preferentially inhibits 3α,5α-THDOC vs. alphaxalone potentiation of GABA-mediated Cl- uptake in adult cerebral cortical synaptoneurosomes, but shows no specificity for 3α,5α-THDOC vs. alphaxalone in recombinant α1β2γ2 receptors. These data provide further evidence of the specificity of 17PA and the heterogeneity of neurosteroid recognition sites on GABAA receptors in the CNS.
Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf
Creators: name: Herdewijn, Piet
name: Van Aerschot, Arthur
name: Dixit, Vidula
name: Fisher, Michael
name: Rozenski, Jef
name: Juliano, Rudy L.
name: Abramov, Mikhail
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Increasing the effectiveness of siRNAs through chemical modification is an important task. Here we describe altritol and hexitol modified oligonucleotides targeting the B-Raf oncogene that is critical for the growth and survival of melanoma cells. Using assays for apoptosis, DNA synthesis, colony formation and B-Raf protein and message levels, we demonstrate that certain hexitol modifications can improve the effectiveness of B-Raf siRNAs and also increase duration of action. Altritol modified siRNAs were similar to or slightly less effective than unmodified B-Raf siRNA. Modifications at the 3′ or 5′ end of the sense strand, at the 3′ end of the antisense strand, or within either strand were well tolerated. The basis for the increased effectiveness of the hexitol-modified siRNAs is not fully understood but may be partly due to increased stability to nucleases.
D1.5 ‐ Data Management Plan
Creators: name: Toska, Merita
Publisher: name: Zenodo
Year: 2022
Subjects: DMP, Green Transition, Research, Western Balkans

description: The Working Package 1 'Project Management and Coordination", Task 1.3 "Data Management Plan (DMP),
 open science practices and Research Data Management" of the GreenFORCE project comprises the Deliverable
 1.5 – Data Management Plan (DMP). This document is the first Version of the DMP, which, as per the Grant
 Agreement, is to be submitted within the 6th month of the GreenFORCE Project, more precisely, within
 31/12/2022. In case needed, an updated second version of the DMP shall be shared in the 18th month of the
 project duration.
 The DMP produced in the framework of the GreenFORCE Project is a living document that describes how
 to research information (research documents and data) will be managed during and after the project duration (the
 data life cycle). The document is prepared based on the Horizon DMP Template1 and reflects the Grant
 Agreement and Consortium Agreement requirements. Furthermore, the DMP describes the data that will be
 generated/created/used, how the generated/created/used data will be shared and preserved in the short and
 long term, and what restrictions (if any) will be applied.
 The approach for the DMP preparation evolved in steps. Preliminarily, all partners in the GreenFORCE Project
 provided information regarding data management policy and practices in respective institutions through a
 structured questionnaire. Part of the information provided has been embedded in the current version of the
 DMP. In a second step, the draft DMP was shared with all partners, providing information regarding research
 documents and data used/produced in the framework of the GreenFORCE Project. Once all comments were
 addressed, the DMP was submitted to the Ethics Advisor for clearance. Finally, the DMP was finalised and
 uploaded into the system on 31/12/2022.
 In its first Version (V1), the DMP provides the general approach and policy to the data management of the
 GreenFORCE Project. It is expected that during the GreenFORCE Project implementation, the DMP will be
 updated regularly and accordingly, gaining precision and substance.
description: {"references": ["References European Commission (2017)., Guidelines to the Rules on Open Access to Scientific Publications and Open Access to Research Data in Horizon 2020. European Commission - Directorate General for Research & Innovation. http://ec.europa.eu/research/participants/data/ref/h2020/grants_manual/hi/oa_pilot/h2020-hi-oa-pilot-guide_en.pdf", "Template for Data Management Plan https://view.officeapps.live.com/op/view.aspx?src=https://www.tuwien.at/fileadmin/Assets/forschung/Zentrum_Forschungsdatenmanagement/data-management-plan-template_HE_2021.docx&wdOrigin=BROWSELINK", "DataCite Metadata Working Group. (2021). DataCite Metadata Schema Documentation for the Publication and Citation of Research Data and Other Research Outputs. Version 4.4. DataCite"]}
Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3β and mitochondrial permeability transition pore
Creators: name: Xi, Jinkun
name: Xu, Zhelong
name: Norfleet, Edward A.
name: Mueller, Robert A.
name: Wang, Huihua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Resveratrol pretreatment can protect the heart by inducing pharmacological preconditioning. Whether resveratrol protects the heart when applied at reperfusion remains unknown. We examined the effect of resveratrol on myocardial infarct size when given at reperfusion and investigated the mechanism underlying the effect. Isolated rat hearts were subjected to 30 min ischemia followed by 2 h of reperfusion, and myocardial samples were collected from the risk zone for Western blot analysis. Mitochondrial swelling was spectrophotometrically measured as a decrease in absorbance at 520 nm (A520). Resveratrol reduced infarct size and prevented cardiac mitochondrial swelling. Resveratrol enhanced GSK-3β phosphorylation upon reperfusion, an effect that was mediated by the cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway. Resveratrol translocated GSK-3β from cytosol to mitochondria via the cGMP/PKG pathway. Further studies showed that mitochondrial GSK-3β was co-immunoprecipitated with cyclophilin D but not with VDAC (voltage dependent anion channel) or ANT (adenine nucleotide translocator). These data suggest that resveratrol prevents myocardial reperfusion injury presumably by targeting the mPTP through translocation of GSK-3β from cytosol to mitochondria. Translocated GSK-3β may ultimately interact with cyclophilin D to modulate the mPTP opening.
Neurochemical profiles of some novel psychoactive substances
Creators: name: Iversen, Les
name: Roth, Bryan L.
name: Setola, Vincent
name: Gibbons, Simon
name: Huang, Xi-Ping
name: Treble, Ric
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Fourteen substances from the class of drugs sometimes known as “legal highs” were screened against a battery of human receptors in binding assays, and their potencies as inhibitors of monoamine uptake determined in functional in vitro assays. Thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations, including 9 potent inhibitors of the dopamine transporter (DAT), 12 potent inhibitors of the norepinephrine transporter (NET) and 4 potent inhibitors of the serotonin transporter (SERT). Seven compounds acted as submicromolar inhibitors of both DAT and NET, and three substances 1-(benzofuran-5-yl)propan-2-amine (5-APB),1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one hydrochloride, (“naphyrone”) and 1-naphthalen-1-yl-2-pyrrolidin-1-ylpentan-1-one hydrochloride, (“1-naphyrone”) were submicromolar inhibitors of all three monoamine transporters. There was a lack of correlation between results of functional uptake experiments and in vitro binding assays for the monoamine transporters. There was also no correlation between the human behavioural effects of the substances and the results of bindings assays for a range of receptor targets, although 1-(benzofuran-5-yl)propan-2-amine(5-APB), 1-(benzofuran-6-yl)propan-2-amine hydrochloride(6-APB) and 5-iodo-2,3-dihydro-1H-inden-2-amine hydrochloride,(5-iodo-aminoindane) exhibited <100nM affinities for 5HT2B and α2C receptors. Functional assays revealed that 5-APB and 6-APB were potent full agonists at 5HT2B receptors.
Multi-rate adaptive transform coding for video compression
Creators: name: Duong, Lyndon R.
name: Li, Bohan
name: Chen, Cheng
name: Han, Jingning
Publisher: name: arXiv
Year: 2022
Subjects: subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Contemporary lossy image and video coding standards rely on transform coding, the process through which pixels are mapped to an alternative representation to facilitate efficient data compression. Despite impressive performance of end-to-end optimized compression with deep neural networks, the high computational and space demands of these models has prevented them from superseding the relatively simple transform coding found in conventional video codecs. In this study, we propose learned transforms and entropy coding that may either serve as (non)linear drop-in replacements, or enhancements for linear transforms in existing codecs. These transforms can be multi-rate, allowing a single model to operate along the entire rate-distortion curve. To demonstrate the utility of our framework, we augmented the DCT with learned quantization matrices and adaptive entropy coding to compress intra-frame AV1 block prediction residuals. We report substantial BD-rate and perceptual quality improvements over more complex nonlinear transforms at a fraction of the computational cost.
description: 5 pages, 4 figures, IEEE ICASSP 2023
Parity-Time Symmetric Coupled Microresonators with a Dispersive Gain/Loss
Creators: name: Phang, Sendy
name: Vukovic, Ana
name: Creagh, Stephen
name: Benson, Trevor M.
name: Sewell, Phillip
name: Gradoni, Gabriele
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The paper reports on the coupling of Parity-Time (PT)-symmetric whispering gallery resonators with realistic material and gain/loss models. Response of the PT system is analyzed for the case of low and high material and gain dispersion, and also for two practical scenarios when the pump frequency is not aligned with the resonant frequency of the desired whispering gallery mode and when there is imbalance in the gain/loss profile. The results show that the presence of dispersion and frequency misalignment causes skewness in frequency bifurcation and significant reduction of the PT breaking point, respectively. Finally, as coupled WGM resonators are inherently lossy structures, we show that unbalancing the gain/loss in resonators is required to compensate for inherent loss of the structure and achieve improved PT properties.
description: 15 pages, 11 figures
Bone mineral density, body mass index, postmenopausal period and outcomes of low back pain treatment in Korean postmenopausal women
Creators: name: Champagne, Catherine
name: Jung, Kwanhye
name: Jin, Eunseok
name: Shin, Joonshik
name: Hong, Soonsung
name: Park, Jongbae J.
name: Lee, Sangho
name: Yeom, Sunkyu
name: Youn, Yousuk
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Women going through menopause experience bone loss and increased musculoskeletal pain, including low back pain. This study explored the relationships between bone mineral density (BMD) and body mass index (BMI), postmenopausal period and outcomes of treatment for low back pain in postmenopausal Korean women. On examining the medical records of 78 postmenopausal women hospitalized for low back pain, investigators found that women with low BMD were older and had been postmenopausal for longer periods than women with normal BMD. Postmenopausal length was positively correlated with pain scores at day 15 and 20 post-admission (P = 0.011 and 0.006) and negatively correlated with T-scores (P = 0.002). BMI was positively correlated with T-scores (r = 0.283, P = 0.022). In conclusion, age, postmenopausal length and BMI correlate with BMD in Korean women suffering from LBP. Larger studies investigating the associations between menopause, BMD, BMI and LBP seem desirable. Moreover, evidence-based therapeutic approaches should be explored for BMD and LBP management.
Prenatal Stress and Fluoxetine Exposure on Autism Spectrum Disorder (ASD) Risk
Creators: name: Arzuaga, Anna L
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Autism spectrum disorder (ASD) is characterized by social and communication impairments as well as restricted and repetitive behaviors (RRBs). RRBs can be expressed as stereotyped motor behaviors or reduced behavioral flexibility. The increased prevalence of ASD in recent decades and the heterogeneity of symptom severity may arise from a complex interplay of genetic and prenatal risk factors that alter mechanisms of synaptic plasticity. Prenatal stress exposure may be one risk factor for an ASD phenotype in offspring. Selective serotonin reuptake inhibitor (SSRI) treatment can be effective in alleviating maternal stress, but prenatal SSRI exposure itself may lead to autism-like behaviors in offspring. To date, unknown is how prenatal stress, SSRI exposure, or the combination interacts with genetic factors to affect repetitive behaviors and synaptic plasticity in offspring. This project investigated whether prenatal exposure to restraint stress and/or fluoxetine treatment affects the expression of RRBs and synaptic plasticity in C57BL/6J (B6) male and female offspring. The project further examined the effects of these prenatal experiences in genetic mouse models associated with monogenic and polygenic syndromes of autism: the Fmr1-knockout (KO) mouse and the BTBR mouse. The findings suggest that restraint stress in B6 pregnant dams reduced sucrose preference and weight gain that was reversed by fluoxetine. In adult B6 offspring, prenatal exposure to restraint stress and/or fluoxetine treatment increased repetitive behavior in only males and contributed to sex-specific deficits in spatial learning. Long-term potentiation (LTP) induced by theta-burst stimulation (TBS) of Schaffer-commissural afferents in field CA1 was significantly impacted in B6 female offspring exposed to restraint stress alone or combined with fluoxetine. Extension of the identical prenatal manipulations on Fmr1-KO and BTBR mice led to differentially adverse effects in the litter survival rate for these mouse models. To address this issue, a moderate restraint stress protocol was implemented. In BTBR adult offspring, prenatal restraint stress and/or fluoxetine exposure led to sex-specific impairments on spatial learning while elevating locomotor behavior in females only. Overall, the findings suggest that prenatal stress and fluoxetine treatment exposure differentially affect a spectrum of autism-like behaviors in adult offspring of varying genetic susceptibility to ASD.
Bose-Hubbard triangular ladder in an artificial gauge field
Creators: name: Halati, Catalin-Mihai
name: Giamarchi, Thierry
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider interacting bosonic particles on a two-leg triangular ladder in the presence of an artificial gauge field. We employ density matrix renormalization group numerical simulations and analytical bosonization calculations to study the rich phase diagram of this system. We show that the interplay between the frustration induced by the triangular lattice geometry and the interactions gives rise to multiple chiral quantum phases. Phase transition between superfluid to Mott-insulating states occur, which can have Meissner or vortex character. Furthermore, a state that explicitly breaks the symmetry between the two legs of the ladder, the biased chiral superfluid, is found for values of the flux close to $π$. In the regime of hardcore bosons, we show that the extension of the bond order insulator beyond the case of the fully frustrated ladder exhibits Meissner-type chiral currents. We discuss the consequences of our findings for experiments in cold atomic systems.
Basic Research in Kidney Cancer
Creators: name: Oosterwijk, Egbert
name: Rathmell, W. Kimryn
name: Brannon, A. Rose
name: Kirkali, Ziya
name: Finley, David S.
name: Mulders, Peter F.A.
name: Pouliot, Frédéric
name: Belldegrun, Arie
name: Uemura, Hirotsugo
name: Junker, Kerstin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: AbstractContextAdvances in basic research will enhance prognosis, diagnosis, and treatment of renal cancer patients.ObjectiveTo discuss advances in our understanding of the molecular basis of renal cancer, targeted therapies, renal cancer and immunity, and genetic factors and renal cell carcinoma (RCC).Evidence acquisitionData on recently published (2005–2011) basic science papers were reviewed.Evidence synthesisAdvances in basic research have shown that renal cancers can be subdivided based on specific genetic profiles. Now that this molecular basis has been established, it is becoming clear that additional events play a major role in the development of renal cancer. For example, aberrant chromatin remodelling appears to be a main driving force behind tumour progression in clear cell RCC. A large number of potential biomarkers have emerged using various high-throughput platforms, but adequate biomarkers for RCC are still lacking. To bring the potential biomarkers and biomarker profiles to the clinical arena is a major challenge for the field.The introduction of tyrosine kinase inhibitors (TKIs) for therapy has shifted the interest away from immunologic approaches. Nevertheless, a wealth of evidence supports immunotherapy for RCC. Interestingly, studies are now appearing that suggest a combination of TKI and immunotherapy may be beneficial.Thus far, little attention has been paid to patient-specific differences. With high-throughput methods becoming cheaper and with the advances in sequencing possibilities, this situation is expected to change rapidly.ConclusionsGreat strides have been made in the understanding of molecular mechanisms of RCC. This has led this field to the enviable position of having a range of molecularly targeted therapies. Large sequencing efforts are now revealing more and more genes responsible for tumour development and progression, offering new targets for therapy. It is foreseen that through integration of high-throughput platforms, personalised cancer treatment for RCC patients will become possible.
Meta-analysis of Clear Cell Renal Cell Carcinoma Gene Expression Defines a Variant Subgroup and Identifies Gender Influences on Tumor Biology
Creators: name: Pruthi, Raj S.
name: Rathmell, W. Kimryn
name: Hacker, Kathryn E.
name: Brannon, A. Rose
name: Nielsen, Matthew E.
name: Wallen, Eric M.
name: Haake, Scott M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Clear cell renal cell carcinoma (ccRCC) displays molecular and histologic heterogeneity. Previously described subsets of this disease, ccA and ccB, were defined based on multigene expression profiles, but it is unclear whether these subgroupings reflect the full spectrum of disease or how these molecular subtypes relate to histologic descriptions or gender.
ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma
Creators: name: Nielsen, Matthew E.
name: Kattan, Michael W.
name: Tamboli, Pheroze
name: Brooks, Samira A.
name: Parker, Joel S.
name: Choueiri, Toni K.
name: Hakimi, A. Ari
name: Sen, Oishee
name: Brannon, A. Rose
name: Fisher, Jennifer C.
name: Hsieh, James J.
name: Maranchie, Jodi K.
name: Rathmell, W. Kimryn
name: Miller, C. Ryan
name: Hinds, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Gene expression signatures have proven to be useful tools in many cancers to identify distinct subtypes of disease based on molecular features that drive pathogenesis, and to aid in predicting clinical outcomes. However, there are no current signatures for kidney cancer that are applicable in a clinical setting.
Adaptation of a U.S. evidence-based Positive Prevention intervention for youth living with HIV/AIDS in Kinshasa, Democratic Republic of the Congo
Creators: name: Chalachala, J.L.
name: Pettifor, A.
name: Edmonds, A.
name: Behets, F.
name: Moracco, K.
name: Parker, L.
name: Maman, S.
name: Golin, C.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Effective HIV prevention programs for people living with HIV/AIDS (PLWH) are important to reduce new infections and to ensure PLWH remain healthy. This paper describes the systematic adaptation of a U.S.-developed Evidence Based Intervention (EBI) using the Centers for Disease Control and Prevention (CDC) Map of Adaption Process for use at a Pediatric Hospital in Kinshasa, Democratic Republic of the Congo (DRC). The adapted intervention, Supporting Youth and Motivating Positive Action or SYMPA, a six-session risk reduction intervention targeted for youth living with HIV/AIDS (YLWH) in Kinshasa was adapted from the Healthy Living Project and guided by the Social Action Theory. This paper describes the process of implementing the first four steps of the ADAPT framework (Assess, Select, Prepare, and Pilot). Our study has shown that an EBI developed and implemented in the U.S. can be adapted successfully for a different target population in a low-resource context through an iterative process following the CDC ADAPT framework. This process included reviewing existing literature, adapting and adding components, and focusing on increasing staff capacity. This paper provides a rare, detailed description of the adaptation process and may aid organizations seeking to adapt and implement HIV prevention EBIs in sub-Saharan Africa and beyond.
Longitudinal Anti-Müllerian Hormone in Women with Polycystic Ovary Syndrome: An Acupuncture Randomized Clinical Trial
Creators: name: Pastore, Lisa M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Others have studied acupuncture treatment for polycystic ovary syndrome (PCOS). Anti-müllerian hormone (AMH) is positively correlated with the ovarian follicle pool, thus making it a useful ovarian reserve measure. AMH is elevated in women with PCOS and has been suggested as a diagnostic tool. This study examined the impact of electroacupuncture on AMH concentration in women with PCOS. Seventy-one women with PCOS participated in a randomized, double-blind, sham-controlled clinical trial of acupuncture. Three longitudinal AMH samples over the 5-month protocol were compared with objective ovulation parameters primarily using nonparametric statistics. Results indicated that AMH levels in PCOS were higher than published norms in women without PCOS. There was no difference between the true and sham acupuncture arms in the change in AMH longitudinally. Baseline AMH, but not the change in AMH over time, was inversely correlated with ovulation and menstrual cycle frequencies in both arms combined (𝑃<0.001). In conclusion, AMH correlated with an increased likelihood of monthly ovulation, as expected from the literature on women without PCOS. The lack of difference by intervention in AMH was consistent with the underlying clinical trial. AMH may be clinically useful to predict which PCOS women are more likely to respond to an intervention.
Quantum-geometric contribution to the Bogoliubov modes in a two-band Bose-Einstein condensate
Creators: name: Iskin, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We consider a weakly-interacting Bose-Einstein condensate (BEC) that is loaded into an optical lattice with a two-point basis, and described by a two-band Bose-Hubbard model with generic one-body and two-body terms. By first projecting the system to the lower Bloch band and then applying the Bogoliubov approximation to the resultant Hamiltonian, we show that the inverse effective-mass tensor of the superfluid carriers in the Bogoliubov spectrum has two physically distinct contributions. In addition to the usual inverse band-mass tensor that is originating from the intraband processes within the lower Bloch band, there is also a quantum-geometric contribution that is induced by the two-body interactions through the interband processes. We also discuss the conditions under which the latter contribution is expressed in terms of the quantum-metric tensor of the Bloch states, i.e., the natural Fubini-Study metric on the Bloch sphere.
description: 8 pages
Regression and Learning to Rank Aggregation for User Engagement Evaluation
Creators: name: Zamani, Hamed
name: Shakery, Azadeh
name: Moradi, Pooya
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Retrieval (cs.IR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: H.2.8; J.4

description: User engagement refers to the amount of interaction an instance (e.g., tweet, news, and forum post) achieves. Ranking the items in social media websites based on the amount of user participation in them, can be used in different applications, such as recommender systems. In this paper, we consider a tweet containing a rating for a movie as an instance and focus on ranking the instances of each user based on their engagement, i.e., the total number of retweets and favorites it will gain. For this task, we define several features which can be extracted from the meta-data of each tweet. The features are partitioned into three categories: user-based, movie-based, and tweet-based. We show that in order to obtain good results, features from all categories should be considered. We exploit regression and learning to rank methods to rank the tweets and propose to aggregate the results of regression and learning to rank methods to achieve better performance. We have run our experiments on an extended version of MovieTweeting dataset provided by ACM RecSys Challenge 2014. The results show that learning to rank approach outperforms most of the regression models and the combination can improve the performance significantly.
description: In Proceedings of the 2014 ACM Recommender Systems Challenge, RecSysChallenge '14
Use of Self-Care and Practitioner-Based Forms of Complementary and Alternative Medicine before and after a Diagnosis of Breast Cancer
Creators: name: Greenlee, Heather
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Purpose. We examine factors associated with self-care, use of practitioner-based complementary and alternative medicine (CAM), and their timing in a cohort of women with breast cancer. Methods. Study participants were women with breast cancer who participated in the Long Island Breast Cancer Study Project. Self-care is defined as the use of multivitamins, single vitamins, botanicals, other dietary supplements, mind-body practices, special diets, support groups, and prayer. Within each modality, study participants were categorized as continuous users (before and after diagnosis), starters (only after diagnosis), quitters (only before diagnosis), or never users. Multivariable logistic regression was used for the main analyses. Results. Of 764 women who provided complete data, 513 (67.2%) initiated a new form of self-care following breast cancer diagnosis. The most popular modalities were those that are ingestible, and they were commonly used in combination. The strongest predictor of continuous use of one type of self-care was continuous use of other types of self-care. Healthy behaviors, including high fruit/vegetable intake and exercise, were more strongly associated with continuously using self-care than starting self-care after diagnosis. Conclusions. Breast cancer diagnosis was associated with subsequent behavioral changes, and the majority of women undertook new forms of self-care after diagnosis. Few women discontinued use of modalities they used prior to diagnosis.