cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Eigenheiten der ältesten Grossplastik Mitteleuropas. Die Statue von Hirschlanden
title: Eigenheiten der ältesten Grossplastik Mitteleuropas. Die Statue von Hirschlanden
titleType: Subtitle
Creators: name: Marzoli, Dirce
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
Non-genetic diversity modulates population performance
Creators: name: Waite, Adam James
name: Frankel, Nicholas W.
name: Dufour, Yann S.
name: Johnston, Jessica F.
name: Long, Junjiajia
name: Emonet, Thierry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cell Behavior (q-bio.CB)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Biological functions are typically performed by groups of cells that express predominantly the same genes, yet display a continuum of phenotypes. While it is known how one genotype can generate such non-genetic diversity, it remains unclear how different phenotypes contribute to the performance of biological function at the population level. We developed a microfluidic device to simultaneously measure the phenotype and chemotactic performance of tens of thousands of individual, freely-swimming Escherichia coli as they climbed a gradient of attractant. We discovered that spatial structure spontaneously emerged from initially well-mixed wild type populations due to non-genetic diversity. By manipulating the expression of key chemotaxis proteins, we established a causal relationship between protein expression, non- genetic diversity, and performance that was theoretically predicted. This approach generated a complete phenotype-to-performance map, in which we found a nonlinear regime. We used this map to demonstrate how changing the shape of a phenotypic distribution can have as large of an effect on collective performance as changing the mean phenotype, suggesting that selection could act on both during the process of adaptation.
title: Vorläufer der mitteleuropäischen keltischen Grossplastik in Italien
title: Vorläufer der mitteleuropäischen keltischen Grossplastik in Italien
titleType: Subtitle
Creators: name: Frey, Otto-Hermann
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
title: Die gallaecischen Kriegerstatuen im Lichte der eisenzeitlichen hispanischen Plastik
title: Die gallaecischen Kriegerstatuen im Lichte der eisenzeitlichen hispanischen Plastik
titleType: Subtitle
Creators: name: Blech, Michael
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
Scattering polarization of the $d$-states of ions and solar magnetic field: Effects of isotropic collisions
Creators: name: Derouich, M.
name: Basurah, H.
name: Badruddin, B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Analysis of solar magnetic fields using observations as well as theoretical interpretations of the scattering polarization is commonly designated as a high priority area of the solar research. The interpretation of the observed polarization raises a serious theoretical challenge to the researchers involved in this field. In fact, realistic interpretations need detailed investigations of the depolarizing role of isotropic collisions with neutral hydrogen. The goal of this paper is to determine new relationships which allow the calculation of any collisional rates of the d-levels of ions by simply determining the value of n^* and $E_p$ without the need of determining the interaction potentials and treating the dynamics of collisions. The determination of n^* and E_p is easy and based on atomic data usually available online. Accurate collisional rates allow a reliable diagnostics of solar magnetic fields. In this work we applied our collisional FORTRAN code to a large number of cases involving complex and simple ions. After that, the results are utilized and injected in a genetic programming code developed with C-langugae in order to infer original relationships which will be of great help to solar applications. We discussed the accurarcy of our collisional rates in the cases of polarized complex atoms and atoms with hyperfine structure. The relationships are expressed on the tensorial basis and we explain how to include their contributions in the master equation giving the variation of the density matrix elements. As a test, we compared the results obtained through the general relationships provided in this work with the results obtained directly by running our code of collisions. These comparisons show a percentage of error of about 10% in the average value.
description: In press in Publications of the Astronomical Society of Australia (PASA) journal, Cambridge Core
Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms
Creators: name: Eldehna, Wagdy M.
name: Taghour, Mohammed S.
name: Al-Warhi, Tarfah
name: Nocentini, Alessio
name: Elbadawi, Mostafa M.
name: Mahdy, Hazem A.
name: Abdelrahman, Mohamed A.
name: Alotaibi, Ohoud J.
name: Aljaeed, Nada
name: Elimam, Diaaeldin M.
name: Afarinkia, Kamyar
name: Abdel-Aziz, Hatem A.
name: Supuran, Claudiu T.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Different 2,4-thiazolidinedione-tethered coumarins 5a–b, 10a–n and 11a–d were synthesised and evaluated for their inhibitory action against the cancer-associated hCAs IX and XII, as well as the physiologically dominant hCAs I and II to explore their selectivity. Un-substituted phenyl-bearing coumarins 10a, 10 h, and 2-thienyl/furyl-bearing coumarins 11a–c exhibited the best hCA IX (KIs between 0.48 and 0.93 µM) and hCA XII (KIs between 0.44 and 1.1 µM) inhibitory actions. Interestingly, none of the coumarins had any inhibitory effect on the off-target hCA I and II isoforms. The sub-micromolar compounds from the biochemical assay, coumarins 10a, 10 h and 11a–c, were assessed in an in vitro antiproliferative assay, and then the most potent antiproliferative agent 11a was tested to explore its impact on the cell cycle phases and apoptosis in MCF-7 breast cancer cells to provide more insights into the anticancer activity of these compounds.
On the trace problem for Triebel--Lizorkin spaces with mixed norms
Creators: name: Johnsen, Jon
name: Sickel, Winfried
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 46E35

description: The subject is traces of Sobolev spaces with mixed Lebesgue norms on Euclidean space. Specifically, restrictions to the hyperplanes given by the first and last coordinates are applied to functions belonging to quasi-homogeneous, mixed-norm Lizorkin--Triebel spaces; Sobolev spaces are obtained from these as special cases. Spaces admitting traces in the distribution sense are characterised except for the borderline cases; these are also covered in case of the first variable. With respect to the first variable the trace spaces are proved to be mixed-norm Lizorkin--Triebel spaces with a specific sum exponent. For the last variable they are similarly defined Besov spaces. The treatment includes continuous right-inverses and higher order traces. The results rely on a sequence version of Nikolskij's inequality, Marschall's inequality for pseudo-differential operators (and Fourier multiplier assertions), as well as dyadic ball criteria.
description: 32 pages. This is the accepted version, with a few unimportant misprints corrected. Appeared in Mathmatische Nachrichten in 2008
Linear Model of RIS-Aided High-Mobility Communication System
Creators: name: Li, Shuaijun
name: Tang, Jie
name: Zheng, Beixiong
name: Song, Xiaokai
name: Pan, Guixin
name: Wong, Kai-Kit
Publisher: name: arXiv
Year: 2025
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Reconfigurable intelligent surface (RIS)-aided vehicle-to-everything (V2X) communication has emerged as a crucial solution for providing reliable data services to vehicles on the road. However, in delay-sensitive or high-mobility communications, the rapid movement of vehicles can lead to random scattering in the environment and time-selective fading in the channel. In view of this, we investigate in this paper an innovative linear model with low-complexity transmitter signal design and receiver detection methods, which boost stability in fast-fading environments and reduce channel training overhead. Specifically, considering the differences in hardware design and signal processing at the receiving end between uplink and downlink communication systems, distinct solutions are proposed. Accordingly, we first integrate the Rician channel introduced by the RIS with the corresponding signal processing algorithms to model the RIS-aided downlink communication system as a Doppler-robust linear model. Inspired by this property, we design a precoding scheme based on the linear model to reduce the complexity of precoding. Then, by leveraging the linear model and the large-scale antenna array at the base station (BS) side, we improve the linear model for the uplink communication system and derive its asymptotic performance in closed-form. Simulation results demonstrate the performance advantages of the proposed RIS-aided high-mobility communication system compared to other benchmark schemes.
description: accepted in IEEE Transactions on Vehicular Technology( Early Access )
title: La escultura en la Hispania Céltica
title: La escultura en la Hispania Céltica
titleType: Subtitle
Creators: name:  Almagro Gorbea, Martín
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
title: Stilistische und formale Beobachtungen an den Kriegerstatuen
title: Stilistische und formale Beobachtungen an den Kriegerstatuen
titleType: Subtitle
Creators: name: Schattner, Thomas G.
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization
Creators: name: Mohammed, Hamada H. H.
name: El-Hafeez, Amer Ali Abd
name: Ebeid, Kareem
name: Mekkawy, Aml I.
name: Abourehab, Mohammed A. S.
name: Wafa, Emad I.
name: Alhaj-Suliman, Suhaila O.
name: Salem, Aliasger K.
name: Ghosh, Pradipta
name: Abuo-Rahma, Gamal El-Din A.
name: Hayallah, Alaa M.
name: Abbas, Samar H.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Physical Sciences not elsewhere classified
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology

description: A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67–62.47 µM, and 4.19–24.37 µM for HCT116, HT29, and Caco-2 cells; respectively, whereas the doxorubicin, showed IC50 values of 1.22, 0.88, and 4.15 µM. Compounds 4a, 4b, 4e, 4i, and 4j were the most potent against HCT116 with IC50 values of 3.57, 4.81, 4.32, 4.87, and 2.53 µM, respectively, compared to doxorubicin (IC50 = 1.22 µM). Also, hybrids 4a, 4b, 4e, 4i, and 4j exhibited remarkable inhibitory activities against topoisomerase I, II, and tubulin polymerisation. They increased the protein expression level of γH2AX, indicating DNA damage, and arrested HCT116 in G2/M phase, possibly through the ATR/CHK1/Cdc25C pathway. Thus, the novel ciprofloxacin hybrids could be exploited as potential leads for further investigation as novel anticancer medicines to fight colorectal carcinoma.
title: As estátuas de guerreiros galaicos como representações de príncipes no contexto da organização político-administrativa do Noroeste préflaviano
title: As estátuas de guerreiros galaicos como representações de príncipes no contexto da organização político-administrativa do Noroeste préflaviano
titleType: Subtitle
Creators: name: de Alarcão, Jorge
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
Additional file 2 of RETRACTED ARTICLE: The role of seed appendage in improving the adaptation of a species in definite seasons: a case study of Atriplex centralasiatica
Creators: name: Wang, Zhaoren
name: Zhao, Yufei
name: Zhang, Yuanyuan
name: Zhao, Baoshan
name: Yang, Zhen’an
name: Dong, Lijia
Publisher: name: figshare
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 2: Table S2. Three-way ANOVA analysis of variance for the germination of type B seed, type B diaspore, type C seed, and type C diaspore of Atriplex centralasiatica respectively.
title: ¿Espejos de piedra? Las imágenes de armas en las estatuas de los guerreros llamados galaicos
title: ¿Espejos de piedra? Las imágenes de armas en las estatuas de los guerreros llamados galaicos
titleType: Subtitle
Creators: name: Quesada-Sanz, Fernando
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
title: Die lusitanisch-galläkischen Kriegerstatuen in ihrem literarischepigraphischen Zusammenhang
title: Die lusitanisch-galläkischen Kriegerstatuen in ihrem literarischepigraphischen Zusammenhang
titleType: Subtitle
Creators: name: Koch, Michael
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors
Creators: name: Jeong, Hee Jin
name: Lee, Hye Lim
name: Kim, Sung Joon
name: Jeong, Jeong Hyun
name: Ji, Su Hyun
name: Kim, Han Byeol
name: Kang, Miso
name: Chung, Hwan Won
name: Park, Chan Sun
name: Choo, Hyunah
name: Yoon, Hyo Jae
name: Kim, Nam-Jung
name: Lee, Duck-Hyung
name: Lee, Sanghee
name: Han, Seo-Jung
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and pyrrolopyridine derivatives and performed structure-activity relationship (SAR) study. We found 18p possessed high potency (IC50 = 25.0 nM) against ENPP1, and activated STING pathway in a concentration dependent manner. Also, in response to STING pathway activation, cytokines such as IFN-β and IP-10 were induced by 18p in a concentration dependent manner. Finally, we discovered that 18p causes inhibition of tumour growth in 4T1 syngeneic mouse model. This study provides new insight into the designing of novel ENPP1 inhibitors and warrants further development of small molecule immune modulators for cancer immunotherapy.
Exact Hausdorff measures of Cantor sets
Creators: name: Forsström, Malin Palö
Publisher: name: arXiv
Year: 2017
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: Cantor sets in \(\mathbb{R}\) are common examples of sets for which Hausdorff measures can be positive and finite. However, there exist Cantor sets for which no Hausdorff measure is supported and finite. The purpose of this paper is to try to resolve this problem by studying an extension of the Hausdorff measures \( μ_h\) on \(\mathbb{R}\), allowing gauge functions to depend on the midpoint of the covering intervals instead of only on the diameter. As a main result, a theorem about the Hausdorff measure of any regular enough Cantor set, with respect to a chosen gauge function, is obtained.
description: 13 pages, 2 figures
title: Os ‘guerreiros lusitano-galaicos’ na história da investigação, a sua datação e interpretação. ‘Cultura castreja’ e ‘Celtas’
title: Os ‘guerreiros lusitano-galaicos’ na história da investigação, a sua datação e interpretação. ‘Cultura castreja’ e ‘Celtas’
titleType: Subtitle
Creators: name: Höck, Martin
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Folgt.
title: Lettre de Jacques Leibowitch au Professeur [Didier] Sicard (Hôpital Cochin)
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111133930920
Novel haptens synthesis and development of a monoclonal antibody-based enzyme-linked immunosorbent assay for leuco-malachite green in fish
Creators: name: Wang, Yu
name: Yang, Jinyi
name: Shen, Yudong
name: Sun, Yuanming
name: Xiao, Zhili
name: Lei, Hongtao
name: Wang, Hong
name: Xu, Zhenlin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: To produce specific antibodies against leuco-malachite green (LMG), 15 haptens were synthesized and characterized, and conjugated to carrier protein for immunization. One antigen with excellent reactogenicity and immunogenicity was discovered. Specific monoclonal antibody with high sensitivity for LMG in competitive indirect enzyme-linked immunosorbent assay (ciELISA) was screened and selected. After the screening of a series of heterologous coating antigen and optimization of working conditions, the proposed ciELISA showed the 50% inhibition value (IC50) of 1.16 ng mL−1 and the limit of detection of 0.06 ng mL−1 for LMG. The average recoveries of LMG from spiked fish samples ranged from 78.0% to 101.0%, with coefficients of variation below 15%. Good correlation (R2 = 0.9977) was obtained between the results of ciELISA analysis and those of standard liquid chromatography–tandem mass spectrometry analysis. The proposed ciELISA is ideal for the rapid and sensitive detection of LMG with a low cost and high throughput.
Optimal probabilistic dense coding schemes
Creators: name: Kögler, Roger Alfredo
name: Neves, Leonardo
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Dense coding with non-maximally entangled states has been investigated in many different scenarios. We revisit this problem for protocols adopting the standard encoding scheme. In this case, the set of possible classical messages cannot be perfectly distinguished due to the non-orthogonality of the quantum states carrying them. So far, the decoding process has been approached in two ways: (i) The message is always inferred, but with an associated (minimum) error; (ii) the message is inferred without error, but only sometimes; in case of failure, nothing else is done. Here, we generalize on these approaches and propose novel optimal probabilistic decoding schemes. The first uses quantum-state separation to increase the distinguishability of the messages with an optimal success probability. This scheme is shown to include (i) and (ii) as special cases and continuously interpolate between them, which enables the decoder to trade-off between the level of confidence desired to identify the received messages and the success probability for doing so. The second scheme, called multistage decoding, applies only for qudits ($d$-level quantum systems with $d>2$) and consists of further attempts in the state identification process in case of failure in the first one. We show that this scheme is advantageous over (ii) as it increases the mutual information between the sender and receiver.
description: 18 pages, 8 figures
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies
Creators: name: Khalifa, Mohamed M.
name: Al-Karmalawy, Ahmed A.
name: Elkaeed, Eslam B.
name: Nafie, Mohamed S.
name: Tantawy, Mohamed A.
name: Eissa, Ibrahim H.
name: Mahdy, Hazem A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed their potent cytotoxic activity with low IC50 values. Topo II inhibition and DNA intercalating activities were evaluated for the most cytotoxic members. IC50 values determination demonstrated Topo II inhibitory activities and DNA intercalating affinities of the tested compounds at a micromolar level. Amongst, compound 9d was the most potent member. It inhibited Topo II enzyme at IC50 value of 7.02 ± 0.54 µM with DNA intercalating IC50 of 26.19 ± 1.14 µM. Compound 9d was then subjected to an in vivo antitumor examination. It inhibited tumour proliferation reducing solid tumour volume and mass. Additionally, it restored liver enzymes, proteins, and CBC parameters near-normal, indicating a remarkable amelioration in their functions along with histopathological examinations.
Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma
Creators: name: Bai, Renren
name: Zhu, Junlong
name: Bai, Ziqiang
name: Mao, Qing
name: Zhang, Yingqian
name: Hui, Zi
name: Luo, Xinyu
name: Ye, Xiang-Yang
name: Xie, Tian
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Cell Biology
Pharmacology
Biological Sciences not elsewhere classified
Cancer

description: Elemene is a second-line broad-spectrum anti-tumour drug that has been used in China for more than two decades. However, its main anti-tumour ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumour efficacy. To improve the anti-tumour activity of β-elemene, based on its minor molecular weight character, we introduced furoxan nitric oxide (NO) donors into the β-elemene structure and designed six series of new generation β-elemene NO donor hybrids. The synthesised compounds could effectively release NO in vitro, displayed significant anti-proliferative effects on U87MG, NCI-H520, and SW620 cell lines. In the orthotopic glioma model, compound Id significantly and continuously suppressed the growth of gliomas in nude mice, and the brain glioma of the treatment group was markedly inhibited (>90%). In short, the structural fusion design of NO donor and β-elemene is a feasible strategy to improve the in vivo anti-tumour activity of β-elemene.
title: Catálogo [Die lusitanisch-galläkischen Kriegerstatuen].
title: Catálogo [Die lusitanisch-galläkischen Kriegerstatuen].
titleType: Subtitle
Creators: name: Calo Lourido, Francisco
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
title: Die lusitanisch-galläkischen Kriegerstatuen
title: Die lusitanisch-galläkischen Kriegerstatuen
titleType: Subtitle
Creators: name: Schattner, Thomas G.
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 44 (2003)
description: Deutsche Zusammenfassung folgt.
title: In memoriam Antonio Arribas Palau (1926–2002)
title: In memoriam Antonio Arribas Palau (1926–2002)
titleType: Subtitle
Creators: name: Schubart, Hermanfrid
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Antonio Arribas Palau (1926–2002)
subject: Antonio Arribas Palau (1926–2002)

description: Madrider Mitteilungen, Vol. 45 (2004)
description: In memoriam Antonio Arribas Palau (1926–2002).
Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity
Creators: name: Said, Mona F.
name: George, Riham F.
name: Petreni, Andrea
name: Supuran, Claudiu T.
name: Mohamed, Nada M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Virology

description: In continuation of our previous studies to optimise potent carbonic anhydrase inhibitors, two new series of isatin N-phenylacetamide based sulphonamides were synthesised and screened for their human (h) carbonic anhydrase (EC 4.2.1.1) inhibitory activities against four isoforms hCA I, hCA II, hCA IX and hCA XII. The indole-2,3-dione derivative 2h showed the most effective inhibition profile against hCAI and hCA II (KI = 45.10, 5.87 nM) compared to acetazolamide (AAZ) as standard inhibitor. Moreover, 2h showed appreciable inhibition activity against the tumour-associated hCA XII, similar to AAZ showing KI of 7.91 and 5.70 nM, respectively. The analogs 3c and 3d showed good cytotoxicity effects, and 3c revealed promising selectivity towards lung cell line A549. Molecular docking was carried out for 2h and 3c to predict their binding conformations and affinities towards the hCA I, II, IX and XII isoforms.
title: Rezeption einer orientalischen Wohnform auf der Iberischen Halbinsel
title: Rezeption einer orientalischen Wohnform auf der Iberischen Halbinsel
titleType: Subtitle
Creators: name: Arnold, Felix
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
Additional file 6 of RETRACTED ARTICLE: The role of seed appendage in improving the adaptation of a species in definite seasons: a case study of Atriplex centralasiatica
Creators: name: Wang, Zhaoren
name: Zhao, Yufei
name: Zhang, Yuanyuan
name: Zhao, Baoshan
name: Yang, Zhen’an
name: Dong, Lijia
Publisher: name: figshare
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 6: Figure S4. The phenotypic characteristic of Atriplex centralasiatica in the study site of Otog Front Banner in northern China.
Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors
Creators: name: Jeong, Hee Jin
name: Lee, Hye Lim
name: Kim, Sung Joon
name: Jeong, Jeong Hyun
name: Ji, Su Hyun
name: Kim, Han Byeol
name: Kang, Miso
name: Chung, Hwan Won
name: Park, Chan Sun
name: Choo, Hyunah
name: Yoon, Hyo Jae
name: Kim, Nam-Jung
name: Lee, Duck-Hyung
name: Lee, Sang Hee
name: Han, Seo-Jung
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and pyrrolopyridine derivatives and performed structure-activity relationship (SAR) study. We found 18p possessed high potency (IC50 = 25.0 nM) against ENPP1, and activated STING pathway in a concentration dependent manner. Also, in response to STING pathway activation, cytokines such as IFN-β and IP-10 were induced by 18p in a concentration dependent manner. Finally, we discovered that 18p causes inhibition of tumour growth in 4T1 syngeneic mouse model. This study provides new insight into the designing of novel ENPP1 inhibitors and warrants further development of small molecule immune modulators for cancer immunotherapy.
Nematic ordering dynamics of an anti-ferromagnetic spin-1 condensate
Creators: name: Symes, L M
name: Blakie, P. B.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We consider the formation of order in a quasi-two-dimensional (quasi-2D) anti-ferromagnetic spin-1 condensate quenched from an easy-axis (EA) to an easy-plane (EP) nematic phase. We define the relevant order parameter to quantify the spin-nematic degrees of freedom and study the evolution of the spin-nematic and superfluid order during the coarsening dynamics using numerical simulations. We observe dynamical scaling in the late time dynamics with both types of order extending across the system with a diffusive growth law. We identify half-quantum vortices (HQVs) as the relevant topological defects of the ordering dynamics, and demonstrate that the growth of both types of order is determined by the mutual annihilation of these vortices.
description: 12 pages, 7 figures
Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease
Creators: name: Zhu, Gaofeng
name: Bai, Ping
name: Wang, Keren
name: Mi, Jing
name: Yang, Jing
name: Hu, Jiaqi
name: Ban, Yujuan
name: Xu, Ran
name: Chen, Rui
name: Wang, Changning
name: Tang, Lei
name: Sang, Zhipei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Cell Biology
Neuroscience
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Mental Health

description: Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32, 0.56, 0.54, 0.73, and 0.86 μM, respectively) and moderate antioxidant activity. Moreover, compounds 5a, 5d, 5e, 5f, and 5h showed potent anti-inflammatory properties, remarkable effects on self-induced Aβ1-42 aggregation, and potent neuroprotective effect on Aβ1-42-induced PC12 cell injury. Furthermore, compounds 5a, 5d, 5e, 5f, and 5h presented good blood–brain barrier permeation in vitro and drug-like properties. More interesting, the PET/CT images with [11C]5f demonstrated that [11C]5f could penetrate the BBB with a high brain uptake and exhibited good brain clearance kinetic property. Therefore, compound 5f would be a promising multi-functional agent for the treatment of AD.
Single crystal growth and characterization of GdRh$_2$Si$_2$
Creators: name: Kliemt, Kristin
name: Krellner, Cornelius
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: High-temperature indium flux growth was applied to prepare single crystals of GdRh$_2$Si$_2$ by a modified Bridgman method leading to mm-sized single crystals with a platelet habitus. Specific heat and susceptibility data of GdRh$_2$Si$_2$ exhibit a pronounced anomaly at $T_N = 107\rm \,K$, where the AFM ordering sets in. Magnetic measurements on the single crystals were performed down to $T = 2$\,K in external fields from B = 0 - 9\,T applied along the $[100]$-, $[110]$- and $[001]$-direction of the tetragonal lattice. The effective magnetic moment determined from a Curie-Weiss fit agrees well with values from literature, and is larger than the theoretically predicted value. Electrical transport data recorded for current flow parallel and perpendicular to the $[001]$-direction show a large anisotropy below $T_N$. The residual resistivity ratio $\rm RRR=ρ_{300K}/ρ_{0}\sim 23$ demonstrates that we succeeded in preparing high-quality crystals using high-temperature indium flux-growth.
Privacy Management and Optimal Pricing in People-Centric Sensing
Creators: name: Alsheikh, Mohammad Abu
name: Niyato, Dusit
name: Leong, Derek
name: Wang, Ping
name: Han, Zhu
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: FOS: Computer and information sciences

description: With the emerging sensing technologies such as mobile crowdsensing and Internet of Things (IoT), people-centric data can be efficiently collected and used for analytics and optimization purposes. This data is typically required to develop and render people-centric services. In this paper, we address the privacy implication, optimal pricing, and bundling of people-centric services. We first define the inverse correlation between the service quality and privacy level from data analytics perspectives. We then present the profit maximization models of selling standalone, complementary, and substitute services. Specifically, the closed-form solutions of the optimal privacy level and subscription fee are derived to maximize the gross profit of service providers. For interrelated people-centric services, we show that cooperation by service bundling of complementary services is profitable compared to the separate sales but detrimental for substitutes. We also show that the market value of a service bundle is correlated with the degree of contingency between the interrelated services. Finally, we incorporate the profit sharing models from game theory for dividing the bundling profit among the cooperative service providers.
description: 16 pages
Additional file 10 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 10: Figure S10. Altered levels of secondary protein modifications in MCI brain pelletomes. Western blots and quantifications of protein secondary modifications. A) Carboxymethyl-lysine (CML). B) Advanced glycation end products (AGE). C) Methylglyoxal (MG). D) 4-hydroxynonenal (HNE). E) Ubiquitin. F) Acetyl-lysine (AcLys). P values are given. Data are presented as mean ± SEM (n = 10/group).
Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups
Creators: name: Wang, Qi
name: Liu, Jie
name: Zhou, Zi-Dan
name: Zhou, Ke-Xin
name: Li, Fei
name: Zhang, Qi-Wen
name: Wang, Shou-Kai
name: Wang, Wei
name: Jin, Zhen
name: Tang, You-Zhi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A series of pleuromutilin derivatives containing alkylamine and nitrogen heterocycle groups were designed and synthesised under mild conditions. The in vitro antibacterial activity of these semisynthetic derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, S.aureus ATCC 29213, S.aureus AD3, and S.aureus 144) were evaluated by the broth dilution method. Compound 13 was found to have excellent antibacterial activity against MRSA (MIC = 0.0625 μg/mL). Furthermore, compound 13 was further studied by the time-killing kinetics and the post-antibiotic effect approach. In the mouse thigh infection model, compound 13 exhibited superior antibacterial efficacy than that of tiamulin. Meanwhile, compound 13 showed a lower inhibitory effect than that of tiamulin on RAW264.7 and 16HBE cells at the concentration of 10 μg/mL. Molecular docking study revealed that compound 13 can effectively bind to the active site of the 50S ribosome (the binding free energy = −9.66 kcal/mol).
Nanoscale Voltage Enhancement at Cathode Interfaces in Li-ion Batteries
Creators: name: Xu, Shenzhen
name: Jacobs, Ryan
name: Wolverton, Chris
name: Kuech, Thomas
name: Morgan, Dane
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Interfaces are ubiquitous in Li-ion battery electrodes, occurring across compositional gradients, regions of multiphase intergrowths, and between electrodes and solid electrolyte interphases or protective coatings. However, the impact of these interfaces on Li energetics remains largely unknown. In this work, we calculated Li intercalation-site energetics across cathode interfaces and demonstrated the physics governing these energetics on both sides of the interface. We studied the olivine/olivine-structured LixFePO4/LixMPO4 (x=0 and 1, M=Co, Ti, Mn) and layered/layered-structured LiNiO2/TiO2 interfaces to explore different material structures and transition metal elements. We found that across an interface from a high- to low-voltage material the Li voltage remains constant in the high-voltage material and decays approximately linearly in the low-voltage region, approaching the Li voltage of the low-voltage material. This effect ranges from 0.5-9nm depending on the interfacial dipole screening. This effect provides a mechanism for a high-voltage material at an interface to significantly enhance the Li intercalation voltage in a low-voltage material over nanometer scale. We showed that this voltage enhancement is governed by a combination of electron transfer (from low- to high-voltage regions), strain and interfacial dipole screening. We explored the implications of this voltage enhancement for a novel heterostructured-cathode design and redox pseudocapacitors.
Additional file 11 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 11: Figure S11. Aggregation of low molecular weight proteins. Gel with fractions marked for cutting. LC/MS/MS data from fraction 1 is listed in Table S7. The first lane on the left (P8) is AD and the second (P9) is the age- and sex-matched control pelletome. Complete LC/MS/MS data from fractions 1–10 are listed in Table S8.
Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease
Creators: name: Sang, Zhipei
name: Song, Qing
name: Cao, Zhongcheng
name: Deng, Yong
name: Zhang, Li
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified

description: A novel series of chalcone-Vitamin E-donepezil hybrids was designed and developed based on multitarget-directed ligands (MTDLs) strategy for treating Alzheimer’s disease (AD). The biological results revealed that compound 17f showed good AChE inhibitory potency (ratAChE IC50 = 0.41 µM; eeAChE IC50 = 1.88 µM). Both the kinetic analysis and docking study revealed that 17f was a mixed type AChE inhibitor. 17f was also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 µM). Moreover, it showed remarkable inhibition of self- and Cu2+-induced Aβ1–42 aggregation with a 78.0 and 93.5% percentage rate at 25 µM, respectively, and disassembled self-induced and Cu2+-induced aggregation of the accumulated Aβ1–42 fibrils with 72.3 and 84.5% disaggregation rate, respectively. More importantly, 17f exhibited a good neuroprotective effect on H2O2-induced PC12 cell injury and presented good blood-brain barrier permeability in vitro. Thus, 17f was a promising multi-target-directed ligand for treating AD.
Additional file 1 of Fungal statin pump protein improves monacolin J efflux and regulates its production in Komagataella phaffii
Creators: name: Bai, Chenxiao
name: Liu, Yiqi
name: Chen, Xinjie
name: Qian, Zhilan
name: Liu, Haifeng
name: Zhou, Xiangshan
name: Zhang, Yuanxing
name: Cai, Menghao
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1. Additional figures and tables.
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
Creators: name: Al-Warhi, Tarfah
name: Elbadawi, Mostafa M.
name: Bonardi, Alessandro
name: Nocentini, Alessio
name: Al-Karmalawy, Ahmed A.
name: Aljaeed, Nada
name: Alotaibi, Ohoud J.
name: Abdel-Aziz, Hatem A.
name: Supuran, Claudiu T.
name: Eldehna, Wagdy M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of generating potent carbonic anhydrase (CA) inhibitors. The adopted strategy involved replacing the 4-fluorophenyl tail in SLC-0111 with a benzothiazole motif that attached to the ureido linker to produce compounds 8c and its regioisomers 8a-b. In addition, the ureido spacer was elongated by methylene or ethylene groups to afford the counterparts 10 and 12. In turn, the primary sulfamoyl zinc binding group (ZBG) was either substituted or replaced by carboxylic acid functionality in order to provide the secondary sulphonamide-based SLC-0111 analogues 16a-b, and the carboxylic acid derivatives 14a-c, respectively. All compounds (8a-c, 10, 12, 14a-c and 16a-b) were tested for their ability to inhibit CA isoforms CA I, II, IX and XII. Additionally, the in vitro anticancer properties of the developed CAIs were evaluated.
title: Sobre las ‘cuidadas iglesias’ de Ibn Hafsun. Estudio de la basílica hallada en la ciudad de Bobastro (Ardales, Málaga)
title: Sobre las ‘cuidadas iglesias’ de Ibn Hafsun. Estudio de la basílica hallada en la ciudad de Bobastro (Ardales, Málaga)
titleType: Subtitle
Creators: name: Martínez Enamorado, Virgilio
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Folgt.
New ALMA and Fermi/LAT Observations of the large-scale jet of PKS 0637-752 Strengthen the Case Against the IC/CMB Model
Creators: name: Meyer, Eileen T.
name: Breiding, Peter
name: Georganopoulos, Markos
name: Oteo, Ivan
name: Zwaan, Martin A.
name: Laing, Robert
name: Godfrey, Leith
name: Ivison, R. J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The Chandra X-ray observatory has discovered several dozen anomalously X-ray-bright jets associated with powerful quasars. A popular explanation for the X-ray flux from the knots in these jets is that relativistic synchrotron-emitting electrons inverse-Compton scatter Cosmic Microwave Background (CMB) photons to X-ray energies (the IC/CMB model). This model predicts a high gamma-ray flux which should be detectable by the Fermi Large Area Telescope (LAT) for many sources. GeV-band upper limits from Fermi/LAT for the well-known anomalous X-ray jet in PKS 0637-752 were previously shown in Meyer et al., (2015) to violate the predictions of the IC/CMB model. Previously, measurements of the jet synchrotron spectrum, important for accurately predicting the gamma-ray flux level, were lacking between radio and infrared wavelengths. Here we present new Atacama Large Millimeter/submillimeter Array (ALMA) observations of the large-scale jet at 100, 233, and 319 GHz which further constrain the synchrotron spectrum, supporting the previously published empirical model. We also present updated limits from the Fermi/LAT using the new `Pass 8' calibration and approximately 30% more time on source. With these deeper limits we rule out the IC/CMB model at the 8.7 sigma level. Finally, we demonstrate that complete knowledge of the synchrotron SED is critical in evaluating the IC/CMB model.
description: Accepted for publication in ApJ Letters (v2 corrects typo in author list)
title: Krone und Kreuz. König Svinthilas. Westgotische Hofkunst und ‘plateinlaying’ im 6. und 7. Jahrhundert
title: Krone und Kreuz. König Svinthilas. Westgotische Hofkunst und ‘plateinlaying’ im 6. und 7. Jahrhundert
titleType: Subtitle
Creators: name: Eger, Christoph
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
title: Baudekor von Munigua
title: Baudekor von Munigua
titleType: Subtitle
Creators: name: Ahrens, Sven
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
Additional file 12 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 12: Table S1. Demographics of AD and control individuals used for proteomics analysis and Western blot studies. Controls were classified as normal individuals.
title: Zur Metallgewinnung von Munigua
title: Zur Metallgewinnung von Munigua
titleType: Subtitle
Creators: name: Schattner, Thomas G.
name: Ovejero Zappino, Gobain
name: Pérez Macías, Juan Aurelio
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.