Additional file 1 of Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss
Creators: name: Jung, Sang-Hyuk
name: Lee, Young Chan
name: Shivakumar, Manu
name: Kim, Jaeyoung
name: Yun, Jae-Seung
name: Park, Woong-Yang
name: Won, Hong-Hee
name: Kim, Dokyoon
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Methods S1-11, Tables S1-16, and Figures S1-5. Method S1. Penn Medicine Biobank banner author list and contribution statements. Method S2. Detailed definition of ARHL. Method S3. Detailed definitions of the covariates in the UK Biobank. Method S4. Detailed definitions of baseline major chronic comorbidities. Method S5. Detailed definitions of lifestyle factors, behaviors, and environmental factors in the UK Biobank. Method S6. Number of missing data for each variable in the UK Biobank. Method S7. Generating of composite healthy lifestyle score. Method S8. Detailed definitions of existing lifestyle score and metabolic syndrome status. Method S9. Detailed information on the genotype data quality control and imputation procedures. Method S10. Generating of polygenic risk score for ARHL. Method S11. Detailed information on statistical analysis. Table S1. Characteristics according to genetic risk group of ARHL in the UK Biobank; Table S2. Demographic comparison of the 85,588 participants included in the composite HLS analysis versus the remaining population within the UK Biobank. Table S3. Characteristics of participants in the Penn Medicine Biobank. Table S4. Odds ratio for ARHL associated with genetic risk group in the UK Biobank and Penn Medicine Biobank. Table S5. Proportion of the variance explained in ARHL by different PRS methods. Table S6. Cox proportional hazard model with age at ARHL onset in the Penn Medicine Biobank. Table S7. Incidence rates of ARHL according to HL PRS risk and age groups in the Penn Medicine Biobank. Table S8. Associations between lifestyle and environmental factors and ARHL. Table S9. Significance of each lifestyle/environmental factor in multivariate regression analysis considering mutual adjustments. Table S10. Significance of the interaction terms between each lifestyle/environmental factor and genetic risk group for ARHL. Table S11. Odds ratio for ARHL associated with healthy lifestyle score (Ideal lifestyle group as a reference). Table S12. Comparison between lifestyle scores and metabolic syndrome status (Ideal lifestyle group as a reference). Table S13. Odds ratio for ARHL according to genetic risk and sex. Table S14. Odds ratio for ARHL according to genetic risk and tinnitus history. Table S15. Odds ratio for ARHL according to Healthy lifestyle score and sex. Table S16. Odds ratio for ARHL according to Healthy lifestyle score and tinnitus history. Fig. S1. Study flowchart. Fig. S2. Flowchart for generating a composite healthy lifestyle score in the UK Biobank. Fig. S3. Density and prevalence plots according to genetic risk for ARHL distribution in the UK Biobank. Fig. S4. Cumulative incidence risk for onset age of ARHL in the Penn Medicine Biobank. Fig. S5. Correlation matrix of lifestyle and environmental factors associated with ARHL.