cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Evaluation of a haemozoin-based rapid diagnostic test for diagnosis of imported malaria during the phase of prevention of reestablishment in Sri Lanka
Creators: name: Fernando, Deepika
name: Thota, Priyaleela
name: Semege, Saveen
name: Booso, Rahuman
name: Bell, David
name: de A. W. Gunasekera, Kumudunayana T.
name: Ranaweera, Prasad
Publisher: name: figshare
Year: 2022
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Table S1. STARD checklist for the reporting of studies of diagnostic accuracy. STARD Checklist.
Near-infrared light curves of Type Ia supernovae: Studying the properties of the second maximum
Creators: name: Dhawan, S.
name: Leibundgut, B.
name: Spyromilio, J.
name: Maguire, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Type Ia supernovae have been proposed to be much better distance indicators at near-infrared compared to optical wavelengths -- the effect of dust extinction is expected to be lower and it has been shown that SNe Ia behave more like `standard candles' at NIR wavelengths. To better understand the physical processes behind this increased uniformity, we have studied the $Y$, $J$ and $H$-filter light curves of 91 SNe Ia from the literature. We show that the phases and luminosities of the first maximum in the NIR light curves are extremely uniform for our sample. The phase of the second maximum, the late-phase NIR luminosity and the optical light curve shape are found to be strongly correlated, in particular more luminous SNe Ia reach the second maximum in the NIR filters at a later phase compared to fainter objects. We also find a strong correlation between the phase of the second maximum and the epoch at which the SN enters the Lira law phase in its optical colour curve (epochs $\sim$ 15 to 30 days after $B$ band maximum). The decline rate after the second maximum is very uniform in all NIR filters. We suggest that these observational parameters are linked to the nickel and iron mass in the explosion, providing evidence that the amount of nickel synthesised in the explosion is the dominating factor shaping the optical and NIR appearance of SNe Ia.
description: 15 pages, 14 figures; Accepted for publication in MNRAS
Advancing biological understanding and therapeutics discovery with small-molecule probes
Creators: name: Wu, M.
name: Reed, J.C.
name: Lindsley, C.W.
name: Chung, T.D.Y.
name: Austin, C.P.
name: Griffin, P.R.
name: Severson, W.E.
name: Stauffer, S.R.
name: Wawer, M.J.
name: Alexander, B.R.
name: Chung, D.-H.
name: Conn, P.J.
name: Roberts, E.
name: Palmer, M.
name: Foley, M.A.
name: McManus, O.
name: Emmitte, K.A.
name: Oprea, T.I.
name: Simeonov, A.
name: Jadhav, A.
name: Sklar, L.A.
name: Hodder, P.S.
name: White, E.L.
name: Bittker, J.A.
name: Ananthan, S.
name: Noah, J.W.
name: Edwards, B.
name: Shamji, A.F.
name: Clemons, P.A.
name: Cravatt, B.F.
name: Golden, J.E.
name: Rosen, H.
name: Pinkerton, A.B.
name: De Souza, A.
name: Yu, H.
name: Zou, B.
name: Aubé, J.
name: Schoenen, F.J.
name: Schreiber, S.L.
name: Kotz, J.D.
name: Jackson, M.R.
name: Wood, M.R.
name: Hopkins, C.R.
name: Li, M.
name: Roush, W.R.
name: Jonsson, C.B.
Publisher: name: Cell Press
Year: 2015

description: Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical tools for investigating biology and disease, small-molecule probes were unavailable for most targets and pathways as recently as a decade ago. In 2005, the NIH launched the decade-long Molecular Libraries Program with the intent of innovating in and broadening access to small-molecule science. This Perspective describes how novel small-molecule probes identified through the program are enabling the exploration of biological pathways and therapeutic hypotheses not otherwise testable. These experiences illustrate how small-molecule probes can help bridge the chasm between biological research and the development of medicines but also highlight the need to innovate the science of therapeutic discovery.
(502499) Edward Thomas Newman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Measurement of the drift velocities of electrons and holes in high-ohmic <100> silicon
Creators: name: Scharf, Christian
name: Klanner, Robert
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Measurements of the drift velocities of electrons and holes as functions of electric field and temperature in high-purity n- and p-type silicon with <100> orientation are presented. The measurements cover electric field values between 2.5 and 50 kV/cm and temperatures between 233 and 333 K. For both electrons and holes differences of more than 15 % are found between our <100> results and the <111> drift velocities from literature, which are frequently also used for simulating <100> sensors. For electrons, the <100> results agree with previous <100> measurements, however, for holes differences between 5 to 15 % are observed for fields above 10 kV/cm. Combining our results with published data of low-field mobilities, we derive parametrizations of the drift velocities in high-ohmic <100> silicon for electrons and holes for fields between 0 and 50 kV/cm, and temperatures between 233 and 333 K. In addition, new parametrizations for the drift velocities for electrons and holes are introduced, which provide somewhat better descriptions of existing data for <111> silicon, than the standard parametrization.
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
Creators: name: Slauson, S.R.
name: Bohn, L.M.
name: Zhou, L.
name: Streicher, J.M.
name: Prisinzano, T.E.
name: Whipple, D.A.
name: Aubé, J.
name: Schoenen, F.J.
name: Lovell, K.M.
name: Frankowski, K.J.
name: Phillips, A.M
Publisher: name: Elsevier Ltd
Year: 2015

description: Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide nitrogen within a tetrahydroisoquinoline moiety afforded a marked increase in potency. This strategy, when combined with additional structure-activity relationship exploration, has led to a compound only six-fold less potent than norBNI, a widely utilized KOR antagonist tool compound, but significantly more synthetically accessible. The new optimized probe is suitably potent for use as an in vivo tool to investigate the therapeutic potential of KOR antagonists.
Additional file 3 of Social network-based measurement of abortion incidence: promising findings from population-based surveys in Nigeria, Cote d’Ivoire, and Rajasthan, India
Creators: name: Bell, Suzanne O.
name: Shankar, Mridula
name: Omoluabi, Elizabeth
name: Anoop Khanna
name: Andoh, Hyacinthe Kouakou
name: Funmilola OlaOlorun
name: Danish Ahmad
name: Guiella, Georges
name: Ahmed, Saifuddin
name: Moreau, Caroline
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Statistics
subject: Science Policy

description: Additional file 3. Characteristics of female respondents age 15 to 49 and their two closest female confidantes age 15 to 49 in Cote d'Ivoire. Estimates weighted, Ns unweighted; bold indicates p-value for design-based F test (reference respondents) less than 0.05. 2Estimate include respondent characteristics in place of "missing" confidantes.
Additional file 1 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Figure 1. Flow chart of study participants. Supplementary Figure 2. Multivariable modelling procedure. Supplementary Figure 3. Complementary feeding practices in the past 24-hours by age when children were 7 to 59 months. Supplementary Figure 4. Percentage of children aged 7 to 59 months who experienced types of learning activities with different caregivers *other adults refers to maternal and paternal grandparents. Supplementary Figure 5. Early childhood index score by gender and wealth index when children were 36 -59 months.
Additional file 1 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Genome editing of zebrafish sorl1. a and b show sections of the sorl1 genomic sequence (ENSG00000137642) with the sense sequence (upper), translation (middle) and anti-sense sequence (lower). a sorl1 exon 2, with the crRNA binding site and PAM sequence for cleavage by Cpf1 indicated by pink arrows, and the R122 site indicated by the orange bar. b sorl1 exon 32, with the C1481 codon indicated by the orange arrow and the TALEN binding sites by blue arrows.
(502490) Louisa Matilda Lovell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Static and Ultrafast Dynamics of Defects of SrTiO3 in LaAlO3/SrTiO3 Heterostructures
Creators: name: Wang, X. Renshaw
name: Chen, J. Q.
name: Barman, A. Roy
name: Dhar, S.
name: Xu, Q. -H.
name: Venkatesan, T.
name: Ariando
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A detailed defect energy level map was investigated for heterostructures of 26 unit cells of LaAlO3 on SrTiO3 prepared at a low oxygen partial pressure of 10-6 mbar. The origin is attributed to the presence of dominating oxygen defects in SrTiO3 substrate. Using femtosecond laser spectroscopy, the transient absorption and relaxation times for various transitions were determined. An ultrafast relaxation process of 2-3 picosecond from the conduction band to the closest defect level and a slower process of 70-92 picosecond from conduction band to intra-band defect level were observed. The results are discussed on the basis of propose defect-band diagram.
description: 11 pages, 4 figures
Additional file 2 of Social network-based measurement of abortion incidence: promising findings from population-based surveys in Nigeria, Cote d’Ivoire, and Rajasthan, India
Creators: name: Bell, Suzanne O.
name: Shankar, Mridula
name: Omoluabi, Elizabeth
name: Anoop Khanna
name: Andoh, Hyacinthe Kouakou
name: Funmilola OlaOlorun
name: Danish Ahmad
name: Guiella, Georges
name: Ahmed, Saifuddin
name: Moreau, Caroline
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Statistics
subject: Science Policy

description: Additional file 2. Characteristics of female respondents age 15 to 49 and their two closest female confidantes age 15 to 49 in Nigeria. Estimates weighted, Ns unweighted; bold indicates p-value for design-based F test (reference respondents) less than 0.05. 2Estimate include respondent characteristics in place of "missing" confidantes; applied post-stratification weights.
Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization
Creators: name: Aubé, J.
name: Moeller, K.D.
name: Milligan, G.L.
name: Liu, R.
name: Frankowski, K.J.
Publisher: name: Wiley-VCH Verlag
Year: 2015

description: Electrochemistry provides a powerful tool for the late-stage functionalization of complex lactams. A two-stage protocol for converting lactams, many of which can be prepared through the intramolecular Schmidt reaction of keto azides, is presented. In the first step, anodic oxidation in MeOH using a repurposed power source provides a convenient route to lactams bearing a methoxy group adjacent to nitrogen. Treatment of these intermediates with a Lewis acid in dichloromethane permits the regeneration of a reactive acyliminium ion that is then reacted with a range of nucleophilic species.
CCR5 gene knock-out mediated TALEN technique and its effects against HIV infection on lymphocytes and macrophages
Creators: name: Liu, Sai
Publisher: name: Imperial College London
Year: 2021

description: Most strains of HIV-1 use CD4 and CCR5 as receptors for cell entry. A naturally occurring CCR5 gene mutation known as CCR5-Δ32 results in CCR5 dysfunction and makes the cells resistant to HIV-1 infection. Previously, two patients who received hematopoietic stem cell transplantation which carried homozygous CCR5-Δ32 have had their HIV-1 infection functionally cured, suggesting that gene-editing targeting CCR5 could make it possible for curing HIV-1 infection. Currently, the transcription activator-like effector nucleases (TALEN) system provides the highest accuracy on gene editing with good efficiency. In this study, I aim to establish a TALEN-based gene-editing platform targeting CCR5 for HIV-1 cure. Previous publication has indicated that mRNA has more advantages than DNA when delivered to the cells. Thus, firstly in this study, I optimized electroporation delivery of mRNAs to the cells and then the protocol of in vitro transcription of mRNA. After transfecting primary T cells with TALEN mRNAs, the expression of surface CCR5 was downregulated. The disruption of the CCR5 gene was confirmed on the genomic level. After HIV-1 challenge, the CCR5 gene-edited primary T cells showed increased HIV-1 resistance. Macrophages also express CD4 and CCR5, which makes them another target of HIV-1 besides CD4+ T cells. Moreover, HIV-1-infected macrophages are more resistant to immune attack and are a key reservoir of HIV-1. Thus, I tested this TALEN system on monocytes-derived-macrophages (MDMs). After transfection of the TALEN mRNAs, the surface CCR5 expression on the MDMs was also downregulated. The CCR5 gene knock-out was confirmed on the genomic level as well. The TALEN-treated MDMS showed increased resistance to HIV-1 infection compared with the un-edited controls after HIV-1 challenge. The result of this study provides evidence and support for using TALEN to knock out CCR5 as a method for curing HIV-1 infection.
(502492) Louisa Matilda [Lovell]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Supplementary Table 1. A summary of indicators available from each of 6-week questionnaire and the follow-up survey sample.
3-Substituted biquinolinium inhibitors of AraC family transcriptional activator VirF from S. flexneri obtained through in situ chemical ionization of 3,4-disubstituted dihydroquinolines
Creators: name: Rogers, S.
name: Neuenswander, B.
name: Jain, P.
name: Porubsky, P.
name: Aubé, J.
name: Li, J.
name: Egan, S.M.
Publisher: name: Royal Society of Chemistry
Year: 2014

description: During a structure-activity relationship optimization campaign to develop an inhibitor of AraC family transcriptional activators, we discovered an unexpected transformation of a previously reported inhibitor that occurs under the assay conditions. Once placed in the assay media, the 3,4-disubstituted dihydroquinoline core of the active analogue rapidly undergoes a decomposition reaction to a quaternary 3-substituted biquinolinium. Further examination established an SAR for this chemotype while also demonstrating its resilience to irreversible binding of biologically relevant nucleophiles.
Impact load mitigation in sandwich beams using local resonators
Creators: name: Sharma, B.
name: Sun, C. T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Dynamic response of sandwich beams with resonators embedded in the cores subjected to impact loads is studied. Using finite element models the effectiveness of various local resonator frequencies under a given impact load is compared to the behavior of an equivalent mass beam. It is shown that addition of appropriately chosen local resonators into the sandwich beam is an effective method of improving its flexural bending behavior under impact loads. The effect of a given local resonance frequency under different impact load durations is also studied. It is demonstrated that the choice of appropriate local resonance frequency depends on the impact duration. Further, by performing transverse impact experiments, the finite element models are verified and the advantage of using internal resonators under impact loading conditions is demonstrated.
description: Currently submitted for review
(502446) Mary Wilson Paterson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 3 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Supplementary Table 2. The timing of the data collection for each of the IYCF indicators and the age range.
Additional file 4 of Social network-based measurement of abortion incidence: promising findings from population-based surveys in Nigeria, Cote d’Ivoire, and Rajasthan, India
Creators: name: Bell, Suzanne O.
name: Shankar, Mridula
name: Omoluabi, Elizabeth
name: Anoop Khanna
name: Andoh, Hyacinthe Kouakou
name: Funmilola OlaOlorun
name: Danish Ahmad
name: Guiella, Georges
name: Ahmed, Saifuddin
name: Moreau, Caroline
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Statistics
subject: Science Policy

description: Additional file 4. Characteristics of female respondents age 15 to 49 and their two closest female confidantes age 15 to 49 in Rajasthan, India. Estimates weighted, Ns unweighted; bold indicates p-value for design-based F test (reference respondents) less than 0.05. Estimate include respondent characteristics in place of "missing" confidantes; post-stratification weights applied.
(502460) Hannah [Cumming]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
$|V_{ub}|$ from $B\toπ\ellν$ decays and (2+1)-flavor lattice QCD
Creators: name: Lattice, Fermilab
name: Collaborations, MILC
name: :
name: Bailey, Jon A.
name: Bazavov, A.
name: Bernard, C.
name: Bouchard, C. M.
name: DeTar, C.
name: Du, Daping
name: El-Khadra, A. X.
name: Foley, J.
name: Freeland, E. D.
name: Gámiz, E.
name: Gottlieb, Steven
name: Heller, U. M.
name: Komijani, J.
name: Kronfeld, A. S.
name: Laiho, J.
name: Levkova, L.
name: Liu, Yuzhi
name: Mackenzie, P. B.
name: Meurice, Y.
name: Neil, E. T.
name: Qiu, Si-Wei
name: Simone, J.
name: Sugar, R.
name: Toussaint, D.
name: Van de Water, R. S.
name: Zhou, Ran
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a lattice-QCD calculation of the $B\toπ\ellν$ semileptonic form factors and a new determination of the CKM matrix element $|V_{ub}|$. We use the MILC asqtad 2+1-flavor lattice configurations at four lattice spacings and light-quark masses down to 1/20 of the physical strange-quark mass. We extrapolate the lattice form factors to the continuum using staggered chiral perturbation theory in the hard-pion and SU(2) limits. We employ a model-independent $z$ parameterization to extrapolate our lattice form factors from large-recoil momentum to the full kinematic range. We introduce a new functional method to propagate information from the chiral-continuum extrapolation to the $z$ expansion. We present our results together with a complete systematic error budget, including a covariance matrix to enable the combination of our form factors with other lattice-QCD and experimental results. To obtain $|V_{ub}|$, we simultaneously fit the experimental data for the $B\toπ\ellν$ differential decay rate obtained by the BaBar and Belle collaborations together with our lattice form-factor results. We find $|V_{ub}|=(3.72\pm 0.16)\times 10^{-3}$ where the error is from the combined fit to lattice plus experiments and includes all sources of uncertainty. Our form-factor results bring the QCD error on $|V_{ub}|$ to the same level as the experimental error. We also provide results for the $B\toπ\ellν$ vector and scalar form factors obtained from the combined lattice and experiment fit, which are more precisely-determined than from our lattice-QCD calculation alone. These results can be used in other phenomenological applications and to test other approaches to QCD.
description: 63 pages, 48 figures; v2: minor changes in Sec. IV, Table X, modified Fig.14,16, results unchanged
Additional file 2 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Generation of mutant zebrafish lines. A detailed description of the isolation of the mutant lines of zebrafish.
Additional file 1 of Comparison of a traditional systematic review approach with review-of-reviews and semi-automation as strategies to update the evidence
Creators: name: Reddy, Shivani M.
name: Patel, Sheila
name: Weyrich, Meghan
name: Fenton, Joshua
name: Viswanathan, Meera
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy

description: Additional file 1: Appendix Table 1. PubMed search string and yield (11/27/2019). Appendix Table 2. Cochrane search string and yield (11/27/2019). Appendix Table 3. AHRQ Evidence Reports and Technology Assessments Search String and Yield (1/7/2019). Table 4. Drug Effectiveness Review Project Drug Class Reviews Search String and Yield (1/7/2019). Table 5. National Guidelines Search String and Yield (1/7/2019). Table 6. ClinicalTrials.gov Search String and Yield (1/10/2019). Table 7. HSRPproj Search String and Yield (1/10/2019). Table 8. PCORI Portfolio Search String and Yield (1/10/2019). Appendix 2: Inclusion and Exclusion Criteria. Appendix 3. Outcomes for Machine Learning Algorithm Only. Table 3A. Semi-automation test with RobotAnalyst using a Training Set of Randomly-Selected Dually-Reviewed Citations with Labels from Title and Abstract Screening: Outcome Metrics for Machine Learning Algorithm Only. Table 3B. Semi-automation test with RobotAnalyst using a Training Set of Dually-Reviewed Citations from a Review-of-Review with Labels from Full Text Screening: Outcome Metrics for Machine Learning Algorithm Only. Table 3C. Semi-automation test with RobotAnalyst using a Training Set of Dually-Reviewed Citations from a Review-of-Review and Randomly-Selected Citations with Labels from Full Text Screening: Outcome Metrics for Machine Learning Algorithm Only. Appendix 4. Cohort Studies Missed by Review of Reviews Approach. Appendix 5: Table AbstrackR Outcomes for Each Training Set.
(502461) Elizabeth Harriet Garrod
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 10 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 10: SORL1 is localized in the MAM in mouse brains. Western blot analysis of subcellular fractions of mouse brain cellular membranes. Each subcellular fraction probed with antibodies against a BACE1, b SORL1 and c LRP/LR. d Shows the identity of fractions western immunoblotting using antibodies recognising proteins MTCO1 in mitochondria (Mito), Na+/K+-ATPase in the plasma membrane (PM), IP3R3 in mitochondrial-associated membranes (MAM), and KDEL, predominantly in non-MAM endoplasmic reticulum (ER). Some cross contamination was observed as MTOC1 was detected in both the mitochondria and plasma membrane, and Na+/K+-ATPase in both the mitochondria and plasma membrane. Lim, A. H. L. (2015). Analysis of the subcellular localization of proteins implicated in Alzheimer's Disease. Genetics and Evolution, University of Adelaide. Doctor of Philosophy (PhD): 235. This figure is reproduced from the Ph.D. thesis of Anne Lim for ease of access.
Additional file 4 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4: Supplementary Table 3. Definition and categorisation of potential explanatory variables used in the study.
Additional file 3 of Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease
Creators: name: Barthelson, Karissa
name: Pederson, Stephen Martin
name: Newman, Morgan
name: Lardelli, Michael
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: No observed bias for differential expression with GC content or length. Plots showing a ranking metric using the sign of logFC multiplied by − log10 of the p-value against a the GC content of the gene and b the length of the gene. The blue curve indicates the line of best fit from a generalised additive model (gam), whilst the black dashed line represents the y = 0 line. Given the gam fit is a nearly horizontal line mostly overlapping y = 0, a significant bias for GC content or length is likely not present in this dataset. The ranking statistic limits were constrained to − 10 and 10 for visualisation purposes, and in b, gene length was plotted on the log10 scale.
High-energy irradiation and mass loss rates of hot Jupiters in the solar neighborhood
Creators: name: Salz, M.
name: Schneider, P. C.
name: Czesla, S.
name: Schmitt, J. H. M. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Giant gas planets in close proximity to their host stars experience strong irradiation. In extreme cases photoevaporation causes a transonic, planetary wind and the persistent mass loss can possibly affect the planetary evolution. We have identified nine hot Jupiter systems in the vicinity of the Sun, in which expanded planetary atmospheres should be detectable through Lyman alpha transit spectroscopy according to predictions. We use X-ray observations with Chandra and XMM-Newton of seven of these targets to derive the high-energy irradiation level of the planetary atmospheres and the resulting mass loss rates. We further derive improved Lyman alpha luminosity estimates for the host stars including interstellar absorption. According to our estimates WASP-80 b, WASP-77 b, and WASP-43 b experience the strongest mass loss rates, exceeding the mass loss rate of HD 209458 b, where an expanded atmosphere has been confirmed. Furthermore, seven out of nine targets might be amenable to Lyman alpha transit spectroscopy. Finally, we check the possibility of angular momentum transfer from the hot Jupiters to the host stars in the three binary systems among our sample, but find only weak indications for increased stellar rotation periods of WASP-77 and HAT-P-20.
description: 11 pages, 5 figures, accepted for publication in A&A
Probing chemical space with alkaloid-inspired libraries
Creators: name: Singh, G.
name: Wang, J.L.
name: Rane, D.
name: Aubé, J.
name: McLeod, M.C.
name: Day, V.W.
name: Plampin, J.N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Screening of small-molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries because of their structural complexity and sp 3 -rich character. Here, we describe the construction of a screening library based on representative members of four families of biologically active alkaloids (Stemonaceae, the structurally related cyclindricine and lepadiformine families, lupin and Amaryllidaceae). In each case, scaffolds were based on structures of the naturally occurring compounds or a close derivative. Scaffold preparation was pursued following the development of appropriate enabling chemical methods. Diversification provided 686 new compounds suitable for screening. The libraries thus prepared had structural characteristics, including sp 3 content, comparable to a basis set of representative natural products and were highly rule-of-five compliant.
(502443) Marion [Molloy nee Williams]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 5 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 5: Supplementary Table 4. Multivariable logistic regression analysis of factors associated with timely initiation of breastfeeding (recall of the first days of life) among children aged 0–12 months. Supplementary Table 5. Multivariable logistic regression analysis of factors associated with colostrum feeding (recall of the first days of life) among children aged 0–12 months. Supplementary Table 6. Multivariable logistic regression analysis of factors associated with no pre-lacteal feeding (recall of the first days of life) among children aged 0–12 months. Supplementary Table 7. Multivariable logistic regression analysis of factors associated with exclusive breastfeeding in past 24 hours before survey among children aged 0–5 months. Supplementary Table 8. Multivariable logistic regression analysis of factors associated with timing of the introduction of solid, semi-solid or soft foods among children aged 7–59 months. Supplementary Table 9. Multivariable logistic regression analysis of factors associated with minimum dietary diversity among children aged 7–59 months. Supplementary Table 10. Multivariable logistic regression analysis of factors associated with consumption of animal foods among children aged 7–59 months. Supplementary Table 11. Multivariable logistic regression analysis of factors associated with consumption of fruits and vegetables among children aged 7–59 months.
(502444) Selena [Wildman]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Aryl nitrenium ions from N-alkyl-N-arylamino-diazonium precursors: Synthesis and reactivity
Creators: name: Huh, C.W.
name: Aubé, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A means of generating an N-alkyl-N-arylaminodiazonium ion, which then loses nitrogen to form a reactive aryl nitrenium intermediate, is described. In this sequence, a set of triazenyl acetonitriles was synthesized by nucleophilic addition of a nitrile anion to an aryl azide followed by temperature-dependent alkylation at either of two nucleophilic triazenyl nitrogen atoms. An α,α-disubstituted acetonitrile and N-arylaminodiazonium moiety (or aryl nitrenium ion upon loss of N2) are embedded in the resulting 1,3,3-trisubsituted triazene, which undergoes liberation and recombination of these two components under acidic conditions to yield an α-arylated acetonitrile containing an all-carbon-quaternary center. We propose that the N-alkyl-N-arylaminodiazonium ion loses nitrogen to generate an aryl nitrenium species, which then reacts with an α,α-disubstituted acetonitrile either at the para- or meta-position of the aromatic ring to afford p-alkylaminoaryl acetonitrile derivatives or 3,3-substituted 1-methylindolin-2-imines, depending on the substrates and conditions.
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold
Creators: name: Shi, J.
name: Zou, B.
name: Aubé, J.
name: Simpson, D.S.
name: Maki, B.E.
name: Li, M.
name: Golden, J.E.
name: Miller, M.
name: McManus, O.B.
name: Wu, M.
name: Flaherty, D.P.
Publisher: name: Elsevier Ltd
Year: 2014

description: TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.
Processing of analogues of plume fallout in cold regions of Enceladus by energetic electrons
Creators: name: Bergantini, A.
name: Pilling, S.
name: Nair, B. G.
name: Mason, N. J.
name: Fraser, H. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Enceladus, a small icy moon of Saturn, is one of the most remarkable bodies in the solar system. This moon is a geologically active object, and despite the lower temperatures on most of its surface, the geothermally heated south polar region presents geysers that spouts a plume made of water (approximately ninety percent), carbon dioxide, methane, ammonia, and methanol, among other molecules. Most of the upward-moving particles do not have the velocity to escape from the gravitational influence of the moon and fall back to the surface. The molecules in the ice are continuously exposed to ionizing radiation, such as UV and X-rays photons, cosmic rays, and electrons. Over time, the ionizing radiation promotes molecular bond rupture, destroying and also forming molecules, radicals, and fragments. We analyse the processing of an ice mixture analogue to the Enceladus fallout ice in cold resurfaced areas (north pole) by 1 keV electrons. The main goal is to search for complex species that have not yet been detected in this moon, and to determine relevant physico-chemical parameters, such as destruction and formation cross-sections and the half-life of the studied molecules in the ice. The experiment consisted of the electron irradiation of an Enceladus-like ice mixture (H2O,CO2,CH4,NH3, and CH3OH) in an ultra-high vacuum chamber at 20 K. The analysis was made by infrared spectrometry in the mid-infrared region (4000-800 cm-1 or 2.5-12.5 microns).The absolute dissociation cross-sections of the parent molecules, the formation cross-section of daughter species, and the half-life of the parental species in a simulated Enceladus irradiation scenario were determined. Among the produced species, CO (carbon monoxide), OCN- (cyanate anion), HCONH2 (formamide), and H2CO (formaldehyde) were tentatively detected.
Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users
Creators: name: Schoenen, F.J.
name: Roy, A.
name: Neul, D.
name: Aubé, J.
name: Scott, E.E.
name: Blake, L.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Purpose: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), one of the most prevalent and procarcinogenic compounds in tobacco, is bioactivated by respiratory cytochrome P450 (CYP) 2A13, forming DNA adducts and initiating lung cancer. CYP2A13 inhibition offers a novel strategy for chemoprevention of tobacco-associated lung cancer. Methods: Twenty-four analogs of a 4-benzylmorpholine scaffold identified by high throughput screening were evaluated for binding and inhibition of both functional human CYP2A enzymes, CYP2A13 and the 94%-identical hepatic CYP2A6, whose inhibition is undesirable. Thus, selectivity is a major challenge in compound design. Results: A key feature resulting in CYP2A13-selective binding and inhibition was substitution at the benzyl ortho position, with three analogs being >25-fold selective for CYP2A13 over CYP2A6. Conclusions: Two such analogs were negative for genetic and hERG toxicities and metabolically stable in human lung microsomes, but displayed rapid metabolism in human liver and in mouse and rat lung and liver microsomes, likely due to CYP2B-mediated degradation. A specialized knockout mouse mimicking the human lung demonstrates compound persistence in lung and provides an appropriate test model. Compound delivered by inhalation may be effective in the lung but rapidly cleared otherwise, limiting systemic exposure.
Additional file 6 of Feeding, caregiving practices, and developmental delay among children under five in lowland Nepal: a community-based cross-sectional survey
Creators: name: Dulal, Sophiya
name: Prost, Audrey
name: Karki, Surendra
name: Merom, Dafna
name: Shrestha, Bhim Prasad
name: Bhandari, Bishnu
name: Manandhar, Dharma S.
name: Osrin, David
name: Costello, Anthony
name: Saville, Naomi M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 6: Supplementary Table 12. Multivariable logistic regression analysis of factors associated with access to three or more books among children aged 7–59. Supplementary Table 13. Multivariable logistic regression analysis of factors associated with access to two or more toys among children aged 7–59. Supplementary Table 14. Multivariable logistic regression analysis of factors associated with early stimulation and responsive caregiving by mother/father/other adults to children aged 24–59 months. Supplementary Table 15. Multivariable logistic regression analysis of factors associated with adequate supervision of children aged 7–59 months. Supplementary Table 16. Multivariable logistic regression analysis of factors associated with attendance of early childhood education by children aged 36–59 months. Supplementary Table 17. Multivariable logistic regression analysis of factors associated with developmentally on track according to ECDI score of children aged 36–59 months.