cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IDGenerator: unique identifier generator for epidemiologic or clinical studies
Creators: name: Olden, Matthias
name: Holle, Rolf
name: Heid, Iris M.
name: Stark, Klaus
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: HEALTH; Identifier; ID; ID generator; ID creator; Unique; Barcode; Check digit; Epidemiologic study; Clinical study
subject: 610 Medizin

description: Background: Creating study identifiers and assigning them to study participants is an important feature in epidemiologic studies, ensuring the consistency and privacy of the study data. The numbering system for identifiers needs to be random within certain number constraints, to carry extensions coding for organizational information, or to contain multiple layers of numbers per participant to diversify data access. Available software can generate globally-unique identifiers, but identifier-creating tools meeting the special needs of epidemiological studies are lacking. We have thus set out to develop a software program to generate IDs for epidemiological or clinical studies. Results: Our software IDGenerator creates unique identifiers that not only carry a random identifier for a study participant, but also support the creation of structured IDs, where organizational information is coded into the ID directly. This may include study center (for multicenter-studies), study track (for studies with diversified study programs), or study visit (baseline, follow-up, regularly repeated visits). Our software can be used to add a check digit to the ID to minimize data entry errors. It facilitates the generation of IDs in batches and the creation of layered IDs (personal data ID, study data ID, temporary ID, external data ID) to ensure a high standard of data privacy. The software is supported by a user-friendly graphic interface that enables the generation of IDs in both standard text and barcode 128B format. Conclusion: Our software IDGenerator can create identifiers meeting the specific needs for epidemiologic or clinical studies to facilitate study organization and data privacy. IDGenerator is freeware under the GNU General Public License version 3; a Windows port and the source code can be downloaded at the Open Science Framework website:https://osf.io/urs2g/.
EFFECT OF JUSTICIA CARNEA LEAF EXTRACT ON PLASMA AND FECAL LIPID PROFILE IN HIGH-FAT DIET FED WISTAR RATS
Creators: name: Onyebuchi, Obia
name: Joy, Eifuobhokhan
Publisher: name: keith journal
Year: 2025
Subjects: Justicia carnea, plasma, fecal, lipid profile

description: The preference for high-fat diets has increased the risk of developing cardio-metabolic metabolic disorders. The aim of this study was to examine the effect of Justicia carnea (JC) leaf extract on plasma and fecal lipid profile [total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL)] in high-fat diet fed wistar rats. The study involved a total of thirty wistar rats separated into six groups of five rats each. Group 1 served as control while groups 2 to 6 were fed with high-fat diet (HFD) throughout the period of the experiment. Group 2 remained untreated, Groups 3, 4 and 5 received respectively 200mg/kg, 500mg/kg and 1000mg/kg of JC extract. Group 6 received 10mg/kg of simvastatin. The animals were fed with the extract for twenty-eight days and thereafter plasma and fecal samples were collected to determine the lipid profile. Daily administration of 200mg/kg of JC caused a significant reduction in the plasma levels of total cholesterol (TC) but significant increase in fecal total cholesterol (FTC). The higher doses also showed a similar pattern but not significantly. Administration of 500mg/kg of JC caused significant increase in plasma TG and HDL compared to the HFD only group. All three doses of JC caused significant reduction in LDL. Conclusively, the results from the present study suggest that JC could possess plasma lipid lowering property and also enhanced fecal excretion of cholesterol. This effect could be possibly due to decreased absorption of lipids and increased fecal excretion of lipids.
Expression of BMP and Actin Membrane Bound Inhibitor (BAMBI) is increased during terminal differentiation of MSCs
Creators: name: Pfeifer, Christian G.
name: Karl, Alexandra
name: Berner, Arne
name: Zellner, Johannes
name: Schmitz, Paul
name: Loibl, Markus
name: Koch, Matthias
name: Angele, Peter
name: Nerlich, Michael
name: Mueller, Michael B.
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: MESENCHYMAL STEM-CELLS; VITRO CARTILAGE FORMATION; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; PSEUDORECEPTOR BAMBI; ENGINEERED CARTILAGE; GENE-EXPRESSION; BETA; HYPERTROPHY;
subject: 610 Medizin

description: Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossification and become hypertrophic. BMP (bone morphogenetic protein) and Activin Membrane Bound Inhibitor (BAMBI) is a pseudoreceptor that regulates the activity of transforming growth factor-beta (TGF-beta) and BMP signalling during chondrogenesis. Both TGF-beta and BMP signalling are regulators of chondrogenic cell differentiation. Human bone marrow derived MSCs were chondrogenically predifferentiated in aggregate culture for 14 days. Thereafter, one group was subjected to hypertrophy enhancing media conditions while controls were kept in chondrogenic medium until day 28. Histological evaluation, gene expression by PCR, and Western blot analysis were carried out at days 1, 3, 7, 14, 17, 21, and 28. A subset of cultures was treated with the BMP inhibitor Noggin to test for BMP dependent expression of BAMBI. Hypertrophic differentiated pellets showed larger cells with increased collagen 10 and alkaline phosphatase staining. There was significantly increased expression of BAMBI on gene expression and protein level in hypertrophic cultures compared to the chondrogenic control and increased BMP4 gene expression. Immunohistochemistry showed intense staining of BAMBI in hypertrophic cells. BAMBI expression was dose-dependently downregulated by Noggin. The pseudoreceptor BAMBI is upregulated upon enhancement of hypertrophy in MSC chondrogenic differentiation by a BMP dependent mechanism.
Saussurea lampsanifolia Franch.
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea lampsanifolia

description: Saussurea lampsanifolia Franch.
Journal de Botanique (Morot) 2: 357 (Franchet 1888).
TYPE SPECIMEN. — China. Yunnan: in silvaticis supra Tapin-tze, 7.IX.1882, J.M. Delavay 604 (holo-, P[P00602863]!).
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520
Gene silencing pathways found in the green alga Volvox carteri reveal insights into evolution and origins of small RNA systems in plants
Creators: name: Dueck, A.
name: Evers, M.
name: Henz, S. R.
name: Unger, K.
name: Eichner, N.
name: Merkl, Rainer
name: Berezikov, E.
name: Engelmann, Julia C.
name: Weigel, D.
name: Wenzl, S.
name: Meister, Gunter
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: HUMAN ARGONAUTE PROTEINS; CHLAMYDOMONAS-REINHARDTII; MIRNAS; ARABIDOPSIS; DATABASE; SIRNAS; PREDICTION; MICRORNA; ELEMENTS; CLASSIFICATION; microRNAs; Gene silencing; Transposons; Small RNAs; Evolution; Argonaute; Volvox carteri
subject: 570 Biowissenschaften, Biologie

description: Background: Volvox carteri (V. carteri) is a multicellular green alga used as model system for the evolution of multicellularity. So far, the contribution of small RNA pathways to these phenomena is not understood. Thus, we have sequenced V. carteri Argonaute 3 (VcAGO3)-associated small RNAs from different developmental stages. Results: Using this functional approach, we define the Volvox microRNA (miRNA) repertoire and show that miRNAs are not conserved in the closely related unicellular alga Chlamydomonas reinhardtii. Furthermore, we find that miRNAs are differentially expressed during different life stages of V. carteri. In addition to miRNAs, transposon-associated small RNAs or phased siRNA loci, which are common in higher land plants, are highly abundant in Volvox as well. Transposons not only give rise to miRNAs and other small RNAs, they are also targets of small RNAs. Conclusion: Our analyses reveal a surprisingly complex small RNA network in Volvox as elaborate as in higher land plants. At least the identified VcAGO3-associated miRNAs are not conserved in C. reinhardtii suggesting fast evolution of small RNA systems. Thus, distinct small RNAs may contribute to multicellularity and also division of labor in reproductive and somatic cells.
Identification of gene expression patterns critically involved in experimental autoimmune encephalomyelitis and multiple sclerosis
Creators: name: Weissert, Robert
name: Herrmann, Martin M.
name: Barth, Silvia
name: Greve, Bernhard
name: Schumann, Kathrin M.
name: Bartels, Andrea
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: MYELIN OLIGODENDROCYTE GLYCOPROTEIN; CELL-DERIVED FACTOR-1; CHEMOKINE RECEPTOR CXCR4; CYCLIC ADP-RIBOSE; PROTEIN-KINASE; T-CELLS; SIGNAL-TRANSDUCTION; LYMPHOID ORGANS; CD38; ACTIVATION; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Central nervous system; Cellular traffic; T cell; Adjuvant
subject: 610 Medizin

description: After encounter with a central nervous system (CNS)-derived autoantigen, lymphocytes leave the lymph nodes and enter the CNS. This event leads only rarely to subsequent tissue damage. Genes relevant to CNS pathology after cell infiltration are largely undefined. Myelin-oligodendrocyte-glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), a chronic autoimmune disease of the CNS that results in disability. To assess genes that are involved in encephalitogenicity and subsequent tissue damage mediated by CNS-infiltrating cells, we performed a DNA microarray analysis from cells derived from lymph nodes and eluted from CNS in LEW.1AV1 (RT1(av1)) rats immunized with MOG 91-108. The data was compared to immunizations with adjuvant alone or naive rats and to immunizations with the immunogenic but not encephalitogenic MOG 73-90 peptide. Here, we show involvement of Cd38, Cxcr4 and Akt and confirm these findings by the use of Cd38-knockout (B6.129P2-Cd38(tm1Lnd)/J) mice, S1P-receptor modulation during EAE and quantitative expression analysis in individuals with MS. The hereby-defined underlying pathways indicate cellular activation and migration pathways mediated by G-protein-coupled receptors as crucial events in CNS tissue damage. These pathways can be further explored for novel therapeutic interventions.
title: La Vera Antichita di Pozzuolo
Creators: name: Capaccio, Giulio Cesare
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Source: Bibliothèque patrimoniale Villon (Rouen), Fonds Montbret, Mt p 5372
Pherbellia patagonensis  1851
Creators: name: Murphy, William L.
name: González, Christian R.
name: Elgueta, Mario
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sciomyzidae
Pherbellia
Pherbellia patagonensis

description: patagonensis (Macquart), 1851
Sciomyza patagonensis Macquart, 1851: 251, pl. 25, fig. 15.
Pherbellia lathraea Steyskal, 1963: 73, fig. 1. Holotype. Male (IML), Argentina, La Rioja, Patquia. Synonymized by Knutson et al. 1976: 5.
Holotype. Male (MNHN), Argentina, Río Negro, Carmen de Patagones
Distribution. Argentina: La Rioja Province (Patquia); Córdoba Province (Cosquín); Buenos Aires Province (Bahía Blanca); Río Negro Province (San Carlos de Bariloche). Brazil: Espírito Santo State (Baixo Guandu); Rio Grande do Sul State (Pelotas). Chile: Región de Valparaíso: San Antonio Province (National Reserve El Yali); Región de La Araucanía: Malleco Province (Icalma); Región de Los Lagos: Llanquihue Province (Puerto Varas, Río Pescado). Ecuador: Imbabura Province (Choucho). Peru: Lima Department (Cartario, Laguna Villa). Uruguay: Montevideo Department (Montevideo).
Reference s. Malloch 1933: 308 (as Pherbellia grisescens); Edwards, in Malloch 1933: 308 (footnote regarding synonymy with Pherbellia grisescens); Steyskal 1963: 121 (fig. 10 male terminalia); Boyes et al. 1969: 333, 345– 347 (cytotaxonomy); Abercrombie 1970: 7 (as Pherbellia); Knutson et al. 1976: 4–5 (catalog); Rozkošný 1987: 18 (synonymy); Marinoni 1995: 133 (list, as Pherbellia patagonensis); Knutson & Vala 2011: 267 (karyotype), 444 (table 21.1 world checklist).
Remarks. N.E. Vikhrev (Moscow, Russia) is investigating the possible synonymy of D. patagonensis with Pherbellia grisescens Meigen, 1830.
description: Published as part of Murphy, William L., González, Christian R. & Elgueta, Mario, 2022, A catalog of the Sciomyzidae of Chile, with a key to genera (Diptera: Sciomyzoidea), pp. 261-278 in Zootaxa 5099 (2) on pages 264-265, DOI: 10.11646/zootaxa.5099.2.6, http://zenodo.org/record/6048580
IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM)
Creators: name: Wege, Anja K.
name: Weber, Florian
name: Kroemer, Alexander
name: Ortmann, Olaf
name: Nimmerjahn, Falk
name: Brockhoff, Gero
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: NATURAL-KILLER-CELL; C-RECEPTOR POLYMORPHISMS; FC-GAMMA RIIIA; IN-VIVO; T-CELLS; OVEREXPRESSING HER2; GENE POLYMORPHISMS; NK CELLS; ANTIBODY; THERAPY; humanized tumor mice (HTM); trastuzumab; IL-15; immunomodulation; breast cancer
subject: 610 Medizin

description: Cancer immunotherapy has been shown to enhance established treatment regimens. We evaluated the potential reinforcing effect of IL-15 in trastuzumab treated humanized tumor mice (HTM) which were generated by concurrent transplantation of neonatal NOD-scid IL2R.null mice with human hematopoietic stem cells (HSC) and HER2 positive breast cancer cells (metastasizing SK-BR-3, solid tumor forming BT474). We found that trastuzumab treatment efficacy mainly depends on the immediate anti-tumorigenic cellular effect which is significantly enhanced by tumor interacting immune cells upon cotransplantion of HSC. However, trastuzumab treatment caused elevated CD44 expression on tumor cells that metastasized into the lung and liver but did not hinder tumor cell dissemination into the bone marrow. Moreover, in a number of SK-BR-3-transplanted animals disseminated CD44(high)/CD24(low) tumor cells lost trastuzumab sensitivity. Concerning the FcYRIIIa polymorphism, trastuzumab treatment efficiency in HTM was higher in mice with NK-cells harboring the high affinity FcYRIIIa compared to those with low affinity Fc.RIIIa. In contrast, IL-15 caused the strongest NK-cell activation in heterozygous low affinity Fc.RIIIa animals. Although IL-15 enhanced the trastuzumab mediated tumor defense, an unspecific immune stimulation resulted in preterm animal death due to systemic inflammation. Overall, treatment studies based on "patient-like" HTM revealed critical and adverse immune-related mechanisms which must be managed prior to clinical testing.
Measuring the Moment-to-Moment Variability of Tinnitus: The TrackYourTinnitus Smart Phone App
Creators: name: Langguth, Berthold
name: Schlee, Winfried
name: Pryss, Rüdiger C.
name: Probst, Thomas
name: Schobel, Johannes
name: Bachmeier, Alexander
name: Reichert, Manfred
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: DAILY-LIFE; POPULATION; DISTRESS; EMOTION; chronic tinnitus; smartphone application; ecological momentary assessment; moment-to-moment analysis; crowd sourcing; ecological validity
subject: 150 Psychologie
subject: 610 Medizin

description: Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnitus perception fluctuates over time. It is therefore necessary to develop tools for measuring fluctuations of tinnitus perception over time and for analyzing data on single subject basis. However, this type of longitudinal measurement is difficult to perform using the traditional research methods such as paper-and-pencil questionnaires or clinical interviews. Ecological momentary assessment (EMA) represents a research concept that allows the assessment of subjective measurements under real-life conditions using portable electronic devices and thereby enables the researcher to collect longitudinal data under real-life conditions and high cost efficiency. Here we present a new method for recording the longitudinal development of tinnitus perception using a modern smartphone application available for iOS and Android devices with no costs for the users. The TrackYourTinnitus (TYT) app is available and maintained since April 2014. A number of 857 volunteers with an average age of 44.1 years participated in the data collection between April 2014 and February 2016. The mean tinnitus distress at the initial measurement was rated on average 13.9 points on the Mini-Tinnitus Questionnaire (Mini-TQ; max. 24 points). Importantly, we could demonstrate that the regular use of the TYT app has no significant negative influence on the perception of the tinnitus loudness nor on the tinnitus distress. The TYT app can therefore be proposed as a safe instrument for the longitudinal assessment of tinnitus perception in the everyday life of the patient.
Saussurea likiangensis Franch.
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea likiangensis

description: Saussurea likiangensis Franch.
Journal de Botanique (Morot) 2: 356 (Franchet 1888).
ACCEPTED NAME. — Saussurea przewalskii Maxim., Bulletin de l’Académie impériale des sciences de St.- Pétersbourg,série 7, 27:494 (Maximowicz 1881).
LECTOTYPE (designated by Lipschitz 1962). — China. Province du Yun-nan, Les coôteaux du Li Kiang suee chan (Li Kiang), terrains dénudés, débris, 13.VIII.1886, J.M. Delavay 2104 (lecto-, P[P00602867]!; isolecto-, P[P00602868, P00602869, P00602870]!).
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520
Anthidium manicatum
Creators: name: Montalva, José
name: Ríos, Mauro
name: Vivallo, Felipe
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Megachilidae
Anthidium
Anthidium manicatum

description: Anthidium manicatum (Linnaeus)
NEW RECORDS: CHILE: 3♂♂ and 1♀: (Metropolitan Region), San Bernardo, Santiago (33°26’31.33”S, 70°40’54.16”W, 580 m. a.s.l), 15 Jan 2015, M. Rios (foraging on Lavandula sp). 3♂♂ and 1♀: (Metropolitan Region), San Bernardo, Santiago (33°26’31.33”S, 70°40’54.16”W, 580 m. a.s.l), 21 Jan 2015, M. Rios (foraging on Lavandula sp). Specimens are deposited in the following Chilean institutions: Museo Nacional de Historia Natural (MNHN), Santiago [2♂♂]; Instituto de Entomología, Universidad Metropolitana de Ciencias de la Educación (UMCE), Santiago [1♂ and 1♀]; and Pontificia Universidad Católica de Valparaíso (PUCV), Valparaíso [2♂♂].
description: Published as part of Montalva, José, Ríos, Mauro & Vivallo, Felipe, 2015, First record of the invasive bee Anthidium manicatum (Hymenoptera: Megachilidae) in Chile, pp. 1-5 in Journal of Melittology 2015 (56) on page 3, DOI: 10.17161/jom.v0i56.4912, http://zenodo.org/record/8057288
Parectinocera Becker 1919
Creators: name: Murphy, William L.
name: González, Christian R.
name: Elgueta, Mario
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sciomyzidae
Parectinocera

description: Genus Parectinocera Becker, 1919: 188
Type-species: Parectinocera neotropica Becker, 1919: 189 (monotypy).
Dichrochirosa Malloch, 1933: 308–309. Type-species: Dichrochirosa inaequalis Malloch, 1933 (original designation). Malloch 1933: 298 (key).
References. Steyskal & Knutson 1975: 275 (key); Knutson et al. 1976: 5 (catalog); Marinoni 1995: 58, 131 (list); Marinoni & Mathis 2000: 165 (character states); 166–167, 170 (phylogeny); 171 (fig. 9 antenna), 174 (phylogeny); 178, 182, 187 (figs. 74, 121, 157 male terminalia); 188 (list); 193 (figs. 216, 217 male terminalia); 195 (phylogeny); 204–205 (figs. 323, 324 phylogeny); Barker et al. 2004: 220 (morphology); Knutson & Vala 2011: 271, 275 (morphology); 298 (key to adults); 324 (taxonomy); 326 (fig. 15.24 phylogeny); 353 (table 16.1 number of species by region); 378 (fig. 17.1 number of species per genus); 388–389 (figs. 17.2, 17.3 phylogeny); 444 (table 21.1 world checklist).
description: Published as part of Murphy, William L., González, Christian R. & Elgueta, Mario, 2022, A catalog of the Sciomyzidae of Chile, with a key to genera (Diptera: Sciomyzoidea), pp. 261-278 in Zootaxa 5099 (2) on page 265, DOI: 10.11646/zootaxa.5099.2.6, http://zenodo.org/record/6048580
Saussurea lingulata Franch.
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea lingulata

description: Saussurea lingulata Franch.
Journal de Botanique (Morot) 10: 423 (Franchet 1896b).
TYPE SPECIMEN. — China. Yunnan occidentalis: in montibus ad vicinitatem fluvii Mékong, H. d’Orléans s.n. (holo-, P[P00602871]!).
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520
NT-proBNP Predicts Cardiovascular Death in the General Population Independent of Left Ventricular Mass and Function: Insights from a Large Population-Based Study with Long-Term Follow-Up
Creators: name: Dietl, Alexander
name: Stark, Klaus
name: Zimmermann, Martina E.
name: Meisinger, Christa
name: Schunkert, Heribert
name: Birner, Christoph
name: Maier, Lars S.
name: Peters, Annette
name: Heid, Iris M.
name: Luchner, Andreas
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: BRAIN NATRIURETIC PEPTIDE; INDUCED HEART-FAILURE; EUROPEAN-ASSOCIATION; AMERICAN-SOCIETY; CHAMBER QUANTIFICATION; OLDER-ADULTS; DYSFUNCTION; MORTALITY; EVENTS; RISK;
subject: 610 Medizin

description: Aims B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) predict cardiovascular endpoints in patients and all-cause death in the general population. This was assigned to their association with clinical cardiac remodelling defined as changes in size, shape and function of the heart. The aim of this study was to evaluate whether NT-proBNP and BNP were associated with cardiovascular and overall death independent of clinical cardiac remodelling measured by echocardiography as left ventricular hypertrophy (LVH), diastolic dysfunction and left ventricular ejection fraction (EF). Methods and Results In a general population-based cohort study from Germany (KORA-S3) with subjects' baseline age ranging from 25 to 74 years, cardiac morphology and function were assessed as left ventricular mass (LVM), diastolic dysfunction and EF by echocardiography and circulating NT-proBNP and BNP were measured at baseline. In 1,223 subjects with mortality follow-up information, we examined the association of baseline NT-proBNP and BNP with cardiovascular mortality (number of deaths = 52, median follow-up time = 12.9years) using Cox regression without and with adjustment for cardiovascular risk factors, LVM, diastolic dysfunction and EF. The risk of cardiovascular mortality increased with higher NT-proBNP levels measured at baseline (hazard ratio HR = 1.67 per unit increment in logNT-proBNP, p = 2.78*10(-4), adjusted for age and sex). This increased risk persisted after adjustment for cardiovascular risk factors, LVM, diastolic dysfunction and EF (HR = 1.73; p = 0.047). When excluding subjects with relevant LVH (LVM to body surface area > 149g/m(2) in men / 122g/m(2) in women), the NT-proBNP association with mortality was still significant (n = 1,138; number of deaths = 35; HR = 1.48; p = 0.04). We found similar results for BNP. Conclusion Our data confirms NT-proBNP and BNP as predictor of cardiovascular mortality in a large general population-based study with long-term follow-up. Our study extends previously published population-based studies to younger and potentially healthier individuals without relevant LVH, diastolic dysfunction or LVD.
Heinen, Karl / Bellebaum, Alfred: Christsein zwischen Entmutigung und Hoffnung
Creators: name: Lippert, Peter
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Introduction to the Latin papyri from Herculaneum: Drafts of an unpublished article.
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 53
description: "Typed drafts of an unpublished article on Latin papyri from Herculaneum with handwritten notes and bibliographical updatings. The working title ('P. Hercul. Lat. Introduction'), the place of composition (Princeton, 1961) and the date of the last revision of the material ('Non publié (1993)') are written on the folder. - Bibliographical annotations on Roman History, later than 1961. – Annotations on palaeography and technical vocabulary of Herculanean papyrology. – Detailed annotations on the Piso family from an unnamed study by R. Syme (possibly The Augustan Aristocracy (1986). - Thematic sections are typed in the upper right corner of the sheet: bibliography, history, unrolling, state of conservation, Philodemus, the Piso family; number of pages are pencil-written in the upper right corner of each page."
description: Source: 4MAR_8_2_5-5
description: created: "n.d., [1961; 1993]"
Fashioning women's agency in Nineteenth-Century Britain: The wearers and makers of historicised fancy dress 1796-1856
Creators: name: Hodge, Sarah
Publisher: name: The Australian National University
Year: 2024

description: In the early nineteenth century, royal and aristocratic women used fancy-dress costume to fashion political and cultural agency in British society. This study, centred around Queen Victoria's costume balls held in 1842, 1845 and 1851, situates those events within the world of elite fashion. By uncovering references to historical figures that inspired guests at those balls, I argue that their costumes were carefully constructed forms of self-expression. Fancy dress was an intricate, luxury commodity, but costumes were often only worn for one night. By contrast, the craftspeople who transformed the costumes from raw material to finished garment, spent weeks working with the materials. Drawing together a range of approaches and literatures, from cultural history to material culture studies, the principal innovation of this study is to recover forgotten histories of the women who wore and made historicised fancy dress to reveal their vital contribution to the vogue for historicism in Britain during the nineteenth century.
PID Component - A reusable Web Component for Visualizing FDOs
Creators: name: Inckmann, Maximilian
name: Pfeil, Andreas
name: Jejkal, Thomas
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2024
Subjects: FAIR Digital Objects
Visualization
Usability
Framework-Agnostic Web-Component

description: The FAIR Digital Objects concept is primarily designed for machine readability, machine interpretability and machine actionability, which results in a highly complex and interconnected infrastructure. To improve the integration, usability, and acceptance of FAIR Digital Objects - especially among non-technical users - it is therefore important to provide user-friendly and straightforward solutions. This work presents the pid-component, a reusable and highly extensible web component for framework-agnostic visualization of a variety of inputs, including Persistent Identifiers (PIDs), Data Types, ORCiDs, and others. For users, the pid-component provides a clean, uniform, and minimalistic interface for consuming FAIR-DOs. For developers, it enables easy integration into their platforms with minimal effort. This is achieved through a highly modular design with a compact form factor, aligning with the height of a single regular text line, and a minimalistic design approach focused on usability. The component relies on a set of W3C web standards and is explorable via an interactive playground that allows developers to understand the capabilities of the pid-component.
Dichrochirosa inaequalis  1933
Creators: name: Murphy, William L.
name: González, Christian R.
name: Elgueta, Mario
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sciomyzidae
Dichrochirosa
Dichrochirosa inaequalis

description: inaequalis (Malloch), 1933
Dichrochirosa inaequalis Malloch, 1933: 309–310.
Holotype. Unspecified sex (NHMUK), Argentina, Río Negro, L. Nahuel Huapi.
Distribution. Argentina: Salta Province (Salta); Neuquén Province (Lago Correntoso); Río Negro Province (Lago Nahuel Huapi at eastern end, San Carlos de Bariloche). Chile: Región de Coquimbo: Elqui Province (La Serena); Región de Valparaíso: Petorca Province (Zapallar), Marga Marga Province (National Park La Campana); Región del Biobío: Arauco Province (Contulmo); Región de La Araucanía: Malleco Province (Angol), Cautín Province (Villarrica); Región de Los Ríos: Valdivia Province (Riñihue, Valdivia); Región de Los Lagos: Llanquihue Province (Carelmapu, Casa Pangue, Peulla, Puerto Varas). Ecuador: Azuay Province (no precise locality). Venezuela: Mérida State (La Mucuy or Mucuy, Tabay 10 km E).
References. Stuardo 1946: 151 (catalog, Dichrochirosa); Knutson et al. 1976: 5 (catalog, Parectinocera); Marinoni 1995: 131 (list); Knutson & Vala 2011: 444 (table 21.1 world checklist).
description: Published as part of Murphy, William L., González, Christian R. & Elgueta, Mario, 2022, A catalog of the Sciomyzidae of Chile, with a key to genera (Diptera: Sciomyzoidea), pp. 261-278 in Zootaxa 5099 (2) on page 265, DOI: 10.11646/zootaxa.5099.2.6, http://zenodo.org/record/6048580
Validity of three asthma-specific quality of life questionnaires: the patients' perspective
Creators: name: Apfelbacher, Christian J.
name: Jones, Christina J.
name: Frew, Anthony
name: Smith, Helen
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: FOCUS GROUPS; SCALE;
subject: 610 Medizin

description: Objectives: It is not known which of the many asthma-specific quality of life (QoL) questionnaires best capture the lived experience of people with asthma. The objective of this study was to explore patients' views of three commonly used asthma-specific QoL questionnaires. Design: Qualitative study using semistructured interviews. Setting: Primary and secondary care in Brighton and Hove, UK. Participants: 30 adult people with a physician-diagnosis of asthma who were asked to complete the Juniper Asthma Quality of Life Questionnaire (AQLQ-J), the Sydney Asthma Quality of Life Questionnaire (AQLQ-S) and the Living with Asthma Questionnaire (LWAQ) to elicit their views on the content validity of these. Results: Thematic content analysis revealed a lack of congruence between the concerns of people with asthma and the questionnaire content in terms of missing (eg, allergies) and irrelevant (eg, smoky restaurants) content. The AQLQ-J was perceived as a 'narrow', 'medical' questionnaire focused on symptoms, the environment and functional ability. In contrast, the LWAQ and the AQLQ-S were perceived to be 'non-medical'. The LWAQ was described as a 'test' and as a wide-ranging, embracing and holistic questionnaire. Its strong emotional focus was irritating to some. The AQLQ-S was described as a simple, quick and easy questionnaire, although there was a perception that it was lacking in depth. Conclusions: Patient interviews highlighted strengths and shortcomings in the content validity of these three asthma-specific questionnaires. For patients, the AQLQ-S content seemed to be the most pertinent in its adequacy of coverage of medical, social and emotional aspects of health-related QoL in asthma.
Saussurea ussuriensis var. mongolica Franch.
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea ussuriensis
Saussurea ussuriensis var. mongolica franch.

description: Saussurea ussuriensis var. mongolica Franch.
Nouvelles Archives du Muséum d’Histoire naturelle (Paris), sér. 2, 6: 61 (Franchet 1883).
ACCEPTED NAME. — Saussurea mongolica Franch. (Franchet 1883: 61), Bulletin de l’Herbier Boissier 5 (7): 539 (Franchet 1897).
LECTOTYPE (designated by Smirnov 2004). — China. Hebei: Gehol [Chengde Co.], VIII.1864, A. David 2141 (lecto-, P[P00602876]!; isolecto-, P[P00602877, P00602878, P00602879]!).
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520
Analytical study on P.Lond inv. 2851.
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 102
description: Photos, typewriten commentary on the papyrus, bibliorgaphical references, personal notes (one handwriten). - Letter by J. F. Gilliam, annotations and two receipts from The Trade unions of EPHS, studies on works by Gilliam and R. Hum. - Offprint by R.O. FINK (Hunt's Pridianum: British Museum Papyrus 2851, «JRS» 48 [1958], 102-116) not annotated, typewriten notes with handwriten corrections and addings, transcription, commentary, palaeographical studies of letters, a map of Dacia.
description: Source: 4MAR_19_3.2-1-1
description: Relation: J. F. Gilliam
description: Coverage: Oregon
description: created: n. d., March 1962
Saussurea longifolia Franch.
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea longifolia

description: Saussurea longifolia Franch.
Journal de Botanique (Morot) 2: 354 (Franchet 1888).
LECTOTYPE (designated by Shi & Raab-Straube 2011). — China. Yunnan: ad collum Yen-tze-kay, prope Lankong, alt. 3200 m, 18.IX.1885, J.M. Delavay 1659 (lecto-, P[P00836207]!; isolecto-, P[P00602872, P00602873]!).
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520
Parectinocera neotropica Becker 1919
Creators: name: Murphy, William L.
name: González, Christian R.
name: Elgueta, Mario
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Sciomyzidae
Parectinocera
Parectinocera neotropica

description: neotropica Becker, 1919: 189
Syntypes. Two females (MNHN), Ecuador, Alausi.
Distribution. Argentina: Catamarca Province (no precise locality). Chile: Región de Valparaíso: Los Andes Province (Piscicultura); Región de La Araucanía: Cautín Province (Villarrica); Región de Los Lagos: Osorno Province (Salto del río Pilmaiquén). Colombia: Antioquía Department (Caldas). Ecuador: Azuay Province (Tarqui, Carchi, El Angel), Chimborazo Province (Alausi), Cotopaxi Province (Salcedo), Pichincha Province.
References. Marinoni 1995: 131 (list); Marinoni & Mathis 2000: 165 (table 1 character states); 171 (fig. 9 antenna); 178, 182, 187 (figs. 74, 121, 167 male terminalia); 193 (figs. 216, 217 male terminalia); Knutson & Vala 2011: 444 (table 21.1 world checklist).
Remarks. The original description cites, “ ♂ ♀, Équateur: Alausi, alt. 2390m, 2 individus; RIVET, 1904.” L.V. Knutson (unpubl.) examined the specimens in 2008 (in last box in main collection). He found no males, and none of the specimens bears a “ type ” label or MNHN number label.
description: Published as part of Murphy, William L., González, Christian R. & Elgueta, Mario, 2022, A catalog of the Sciomyzidae of Chile, with a key to genera (Diptera: Sciomyzoidea), pp. 261-278 in Zootaxa 5099 (2) on page 265, DOI: 10.11646/zootaxa.5099.2.6, http://zenodo.org/record/6048580
Saussurea macrota Franch. (Franchet 1894
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea macrota

description: Saussurea macrota Franch.
(Fig. 8)
Journal de Botanique (Morot) 8: 343 (Franchet 1894).
Saussurea auriculata Hemsl., Journal of the Linnean Society. Botany 29: 308 (Hemsley 1892). — Saussurea macrota var. papyracea S.Ju. Lipschitz, Rod Saussurea: 210 (Lipschitz 1979). — Saussurea hemsleyana Hand. -Mazz., Notizblatt des Botanischen Gartens und Museums zu Berlin-Dahlem 13: 647 (Handel-Mazzetti 1937). — Saussurea otophylla Diels, Botanische Jahrbücher für Systematik 36 (5, Beibl. 82): 109 (Diels 1905).
LECTOTYPE (here designated). — China. Se-tchuen (Sichuan) oriental, sur les montagnes de Tchen-Kéou-tin, alt. 2500 m, P.G. Farges s.n. (lecto-, P[P00602874]!; isolecto-, P[P00602875]!).
REMARKS
In the protologue, Franchet (1894) mentioned the following locality information: “Se-tchuen (Sichuan) oriental, sur les montagnes de Tchen-Kéou-tin, alt. 2500 m (P.G. Farges s.n.) as the type, without indicating the herbaria where the specimen was deposited. Lipschitz (1964) cited TYPUS: Se-tchuen (Sichuan) oriental, sur les montagnes de Tchen-Kéou-tin, alt. 2500 m “ P.G. Farges s.n. ” in P [first-step], which is considered an inadvertent lectotyification according to Art. 7.11 of ICN (Turland et al. 2018). We traced two duplicate specimens in P (P00602874, P00602875). According to ICN, Arts 9.6, and 40, Note 1 (Turland et al. 2018), none of them can be treated as holotype, but should be regarded as syntypes. After careful examination of two sheets deposited in P, it is necessary to select one of them as the lectotype (ICN; Art. 9.17, Turland et al. 2018). We designate here the blooming specimen “ P.G. Farges s.n. ” in P (P00602874) as the lectotype [second-step]. The selected sheet is morphologically complete and well-preserved specimen that displays all the morphological diagnostic traits in agreement with the protologue.
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520
Can Consistent Benchmarking within a Standardized Pain Management Concept Decrease Postoperative Pain after Total Hip Arthroplasty? A Prospective Cohort Study including 367 Patients
Creators: name: Benditz, Achim
name: Greimel, Felix
name: Auer, Patrick
name: Zeman, Florian
name: Göttermann, Antje
name: Grifka, Joachim
name: Meissner, Winfried
name: von Kunow, Frederik
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: QUALITY IMPROVEMENT; POSTSURGICAL PAIN; PERCEPTIONS; ANALGESIA; KNOWLEDGE; THERAPY; postoperative pain; total hip arthroplasty; pain management concept; benchmarking
subject: 610 Medizin

description: Background: The number of total hip replacement surgeries has steadily increased over recent years. Reduction in postoperative pain increases patient satisfaction and enables better mobilization. Thus, pain management needs to be continuously improved. Problems are often caused not only by medical issues but also by organization and hospital structure. The present study shows how the quality of pain management can be increased by implementing a standardized pain concept and simple, consistent, benchmarking. Methods: All patients included in the study had undergone total hip arthroplasty (THA). Outcome parameters were analyzed 24 hours after surgery by means of the questionnaires from the German-wide project "Quality Improvement in Postoperative Pain Management" (QUIPS). A pain nurse interviewed patients and continuously assessed outcome quality parameters. A multidisciplinary team of anesthetists, orthopedic surgeons, and nurses implemented a regular procedure of data analysis and internal benchmarking. The health care team was informed of any results, and suggested improvements. Every staff member involved in pain management participated in educational lessons, and a special pain nurse was trained in each ward. Results: From 2014 to 2015, 367 patients were included. The mean maximal pain score 24 hours after surgery was 4.0 (+/- 3.0) on an 11-point numeric rating scale, and patient satisfaction was 9.0 (+/- 1.2). Over time, the maximum pain score decreased (mean 3.0, +/- 2.0), whereas patient satisfaction significantly increased (mean 9.8, +/- 0.4; p<0.05). Among 49 anonymized hospitals, our clinic stayed on first rank in terms of lowest maximum pain and patient satisfaction over the period. Conclusion: Results were already acceptable at the beginning of benchmarking a standardized pain management concept. But regular benchmarking, implementation of feedback mechanisms, and staff education made the pain management concept even more successful. Multidisciplinary teamwork and flexibility in adapting processes seem to be highly important for successful pain management.
Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated With Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase
Creators: name: Schmid, Peter M.
name: Bouazzaoui, Karin
name: Schmid, Karin
name: Birner, Christoph
name: Schach, Christian
name: Maier, Lars
name: Holler, Ernst
name: Endemann, Dierk H.
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; NITRIC-OXIDE; INTERFERON-GAMMA; ENDOTHELIAL DYSFUNCTION; IFN-GAMMA; RESISTANCE ARTERIES; MOUSE LUNG; INTERLEUKIN-10; MICE; Vascular graft-versus-host disease (GVHD); Indoleamine 2,3-dioxygenase (IDO); Adiponectin (APN); Cytokines
subject: 610 Medizin

description: Graft-versus-host disease (GVHD) is the limiting complication after bone marrow transplantation (BMT), and its pathophysiology seems to be highly influenced by vascular factors. Our study aimed at elucidating possible mechanisms involved in vascular GVHD. For this purpose, we used a fully MHC-mismatched model of BALB/c mice conditioned according to two different intensity protocols with total body irradiation and transplantation of allogeneic (C57BL/6) or syngeneic bone marrow cells and splenocytes. Mesenteric resistance arteries were studied in a pressurized myograph. We also quantified the expression of indoleamine 2,3-dioxygenase (IDO), endothelial (eNOS), and inducible NO synthase (iNOS), as well as several pro-and anti-inflammatory cytokines. We measured the serum levels of tryptophan (trp) and kynurenine (kyn), the kyn/trp ratio (KTR) as a marker of IDO activity, and adiponectin (APN). The myographic study showed a correlation of GVHD severity after allogeneic BMT with functional vessel alterations that started with increased vessel stress and ended in eccentric vessel remodeling, increased vessel strain, and endothelial dysfunction. These alterations were accompanied by increasing IDO activity and decreasing APN levels in the serum of allogeneic animals. The mRNA expression showed significantly elevated IDO, decreased eNOS, and elevation of most studied pro-and anti-inflammatory cytokines. Our study provides further data supporting the importance of vessel alterations in GVHD and is the first to show an association of vascular GVHD with hypoadiponectinemia and an increased activity and vascular expression of IDO. Whether there is also a causative involvement of these two factors in the development of GVHD needs to be further investigated.
Fluorescein sodium-guided surgery of a brain abscess – A Case Report
Creators: name: Höhne, Julius
name: Brawanski, Alexander
name: Schebesch, Karl-Michael
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: Blood–brain barrier, brain abscess, fluorescein sodium, fluorescence-guided surgery, YELLOW 560 nm filter
subject: 610 Medizin

description: Background:
Up to now, the feasibility and benefit of using fluorescein sodium under a dedicated surgical microscope filter (YE560, YELLOW 560 nm filter, Carl Zeiss Meditec, Germany) has never been clinically evaluated in infectious disorders of the brain.

Case Description:
Here, we report the case of a male patient with a brain abscess in the right parietal lobe that was removed under fluorescence-guidance (intravenous administration of fluorescein sodium 10%, 5 mg/kg bodyweight). The abscess capsule showed intensive yellow fluorescent staining, while − under white light − the cortex appeared normal.

Conclusion:
This technique may improve the identification and surgical removal of brain abscesses.
Chang Ch´ Un-Shen, A.B.: Dann sind Himmel und Mensch in Einheit
Creators: name: Römelt, Johannes
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 28 (1987): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 28
Saussurea nikoensis Franch. & Sav.
Creators: name: Jibran, Muhammad
name: Idrees, Muhammad
name: Zhang, Zhiyong
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Saussurea
Saussurea nikoensis

description: Saussurea nikoensis Franch. & Sav.
Enumeratio Plantarum in Japonia sponte Crescentium 2: 407 (Franchet & Savatier 1878).
TYPE SPECIMEN. — Japan. Alpes de Nikko, without date, P.A.L. Savatier 2099 (holo-, P[P00484393]!).
description: Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 126, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/7841520