cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sonnenfleckenzeichnung Nr. 277.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 27.11.2008, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 54.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.03.2008, 08:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification
Creators: name: Murray, Matthew J.
name: Ho, Catherine M. K.
name: Strang, Blair L.
name: Zuercher, William J.
name: Khan, Amina S.
name: Reeves, Matthew B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: To identify new compounds with anti-human cytomegalovirus (HCMV) activity and new anti-HCMV targets, we developed a high-throughput strategy to screen a GlaxoSmithKline Published Kinase Inhibitor Set. This collection contains a range of extensively characterized compounds grouped into chemical families (chemotypes). From our screen, we identified compounds within chemotypes that impede HCMV protein production and identified kinase proteins associated with inhibition of HCMV protein production that are potential novel anti-HCMV targets. We focused our study on a top ‘hit’ in our screen, SB-734117, which we found inhibits productive replication of several HCMV strains. Kinase selectivity data indicated that SB-734117 exhibited polypharmacology and was an inhibitor of several proteins from the AGC and CMCG kinase groups. Using Western blotting, we found that SB-734711 inhibited accumulation of HCMV immediate-early proteins, phosphorylation of cellular proteins involved in immediate-early protein production (cAMP response element-binding protein and histone H3) and histone H3 lysine 36 trimethylation (H3K36me3). Therefore, we identified SB-734117 as a novel anti-HCMV compound and found that inhibition of AGC and CMCG kinase proteins during productive HCMV replication was associated with inhibition of viral protein production and prevented post-translational modification of cellular factors associated with viral protein production.
Sonnenfleckenzeichnung Nr. 9.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.01.2008, 08:45, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Detecting underabundant neutralinos
Creators: name: Badziak, Marcin
name: Delgado, Antonio
name: Olechowski, Marek
name: Pokorski, Stefan
name: Sakurai, Kazuki
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The electroweak sector may play a crucial role in discovering supersymmetry. We systematically investigate the patterns of the MSSM-like electroweakinos, when the neutralino relic abundance $Ω_χh^2\leq 0.12$, that is, also admitting for multi-component Dark Matter, in a broad range of the parameter space. We find that for a very large range of parameters the Direct Detection experiments are/will be sensitive to underabundant neutralinos, in spite of the strong rescaling of the flux factor. The second general conclusion is that the bound $Ω_χh^2\leq 0.12$ together with the LUX (XENON1T) limits for the neutralino spin independent scattering cross sections constrain the electroweakino spectrum so that the mass differences between the NLSP and the LSP are smaller than 40 (10) GeV, respectively, with important implications for the collider searches. The future Direct Detection experiments and the high luminosity LHC run will probe almost the entire range of the LSP and NLSP mass spectrum that is consistent with the bound $Ω_χh^2\leq 0.12$.
description: 36 pages, 15 figures
Begonia maracayuensis D. Parodi, Anales Soc. Ci. Argent.
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Cucurbitales
Begoniaceae
Begonia
Begonia maracayuensis

description: Begonia maracayuensis D.Parodi, Anales Soc. Ci. Argent. 5: 209. 1878.
Herb.
 Vouchers: unknown (Golding & Wasshausen 2002).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Effect of the lung allocation score on lung transplantation in the United States
Creators: name: Egan, Thomas M.
name: Edwards, Leah B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: BACKGROUND: On May 4, 2005, the system for allocation of deceased donor lungs for transplant in the United States changed from allocation based on waiting time to allocation based on the lung allocation score (LAS). We sought to determine the effect of the LAS on lung transplantation in the United States.

METHODS: Organ Procurement and Transplantation Network data on listed and transplanted patients were analyzed for 5 calendar years before implementation of the LAS (2000-2004), and compared with data from 6 calendar years after implementation (2006-2011). Counts were compared between eras using the Wilcoxon rank sum test. The rates of transplant increase within each era were compared using an F-test. Survival rates computed using the Kaplan-Meier method were compared using the log-rank test.

RESULTS: After introduction of the LAS, waitlist deaths decreased significantly, from 500/year to 300/year; the number of lung transplants increased, with double the annual increase in rate of lung transplants, despite no increase in donors; the distribution of recipient diagnoses changed dramatically, with significantly more patients with fibrotic lung disease receiving transplants; age of recipients increased significantly; and 1-year survival had a small but significant increase.

CONCLUSIONS: Allocating lungs for transplant based on urgency and benefit instead of waiting time was associated with fewer waitlist deaths, more transplants performed, and a change in distribution of recipient diagnoses to patients more likely to die on the waiting list.
PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management: The PREVENT multi-center study
Creators: name: Brieke, Andreas
name: Ransom, John
name: Egnaczyk, Gregory
name: Nathan, Sriram
name: Adamson, Robert
name: Stulak, John
name: Kilic, Ahmet
name: Uriel, Nir
name: Sheridan, Brett
name: Entwistle, John W.
name: Emani, Sitaramesh
name: Maltais, Simon
name: Farrar, David J.
name: Keebler, Mary
name: Katz, Jason N.
name: O'Connell, John B.
name: Sundareswaran, Kartik S.
name: Gregoric, Igor
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Recommended structured clinical practices including implant technique, anti-coagulation strategy, and pump speed management (PREVENT [PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management] recommendations) were developed to address risk of early (<3 months) pump thrombosis (PT) risk with HeartMate II (HMII; St. Jude Medical, Inc. [Thoratec Corporation], Pleasanton, CA). We prospectively assessed the HMII PT rate in the current era when participating centers adhered to the PREVENT recommendations.

METHODS: PREVENT was a prospective, multi-center, single-arm, non-randomized study of 300 patients implanted with HMII at 24 participating sites. Confirmed PT (any suspected PT confirmed visually and/or adjudicated by an independent assessor) was evaluated at 3 months (primary end-point) and at 6 months after implantation.

RESULTS: The population included 83% men (age 57 years ± 13), 78% destination therapy, and 83% Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Profile 1-3. Primary end-point analysis showed a confirmed PT of 2.9% at 3 months and 4.8% at 6 months. Adherence to key recommendations included 78% to surgical recommendations, 95% to heparin bridging, and 79% to pump speeds ≥9,000 RPMs (92% >8,600 RPMs). Full adherence to implant techniques, heparin bridging, and pump speeds ≥9,000 RPMs resulted in a significantly lower risk of PT (1.9% vs 8.9%; p < 0.01) and lower composite risk of suspected thrombosis, hemolysis, and ischemic stroke (5.7% vs 17.7%; p < 0.01) at 6 months.

CONCLUSIONS: Adoption of all components of a structured surgical implant technique and clinical management strategy (PREVENT recommendations) is associated with low rates of confirmed PT.
Begonia obovatistipula C. DC., Bull. Soc. Bot. Genève
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Cucurbitales
Begoniaceae
Begonia
Begonia obovatistipula

description: Begonia obovatistipula C.DC., Bull. Soc. Bot. Genève, sér. 2(6): 124, pl. 6. 1914.
Herb.
 Vouchers: Concepción: Fiebrig 4514, type (G, K). Unknown: Mereles 281 (FCQ).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
The subarcsecond mid-infrared view of local active galactic nuclei: II. The mid-infrared--X-ray correlation
Creators: name: Asmus, D.
name: Gandhi, P.
name: Hoenig, S. F.
name: Smette, A.
name: Duschl, W. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an updated mid-infrared (MIR) versus X-ray correlation for the local active galactic nuclei (AGN) population based on the high angular resolution 12 and 18um continuum fluxes from the AGN subarcsecond MIR atlas and 2-10 keV and 14-195 keV data collected from the literature. We isolate a sample of 152 objects with reliable AGN nature and multi-epoch X-ray data and minimal MIR contribution from star formation. Although the sample is not homogeneous or complete, we show that our results are unlikely to be affected by biases. The MIR--X-ray correlation is nearly linear and within a factor of two independent of the AGN type and the wavebands used. The observed scatter is <0.4 dex. A possible flattening of the correlation slope at the highest luminosities probed (~ 10^45 erg/s) is indicated but not significant. Unobscured objects have, on average, an MIR--X-ray ratio that is only <= 0.15 dex higher than that of obscured objects. Objects with intermediate X-ray column densities (22 < log N_H < 23) actually show the highest MIR--X-ray ratio on average. Radio-loud objects show a higher mean MIR--X-ray ratio at low luminosities, while the ratio is lower than average at high luminosities. This may be explained by synchrotron emission from the jet contributing to the MIR at low-luminosities and additional X-ray emission at high luminosities. True Seyfert 2 candidates and double AGN do not show any deviation from the general behaviour. Finally, we show that the MIR--X-ray correlation can be used to verify the AGN nature of uncertain objects. Specifically, we give equations that allow to determine the intrinsic 2-10 keV luminosities and column densities for objects with complex X-ray properties to within 0.34 dex. These techniques are applied to the uncertain objects of the remaining AGN MIR atlas, demonstrating the usefulness of the MIR--X-ray correlation as an empirical tool.
description: Accepted for publication in MNRAS, 40 pages, 25 figures
Clustering of extreme events created by multiple correlated maxima
Creators: name: Azevedo, Davide
name: Freitas, Ana Cristina Moreira
name: Freitas, Jorge Milhazes
name: Rodrigues, Fagner Bernardini
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 37A50, 60G55, 60G70, 37B20, 60G10, 37C25

description: We consider stochastic processes arising from dynamical systems by evaluating an observable function along the orbits of the system. The novelty is that we will consider observables achieving a global maximum value (possible infinite) at multiple points with special emphasis for the case where these maximal points are correlated or bound by belonging to the same orbit of a certain chosen point. These multiple correlated maxima can be seen as a new mechanism creating clustering. We recall that clustering was intimately connected with periodicity when the maximum was achieved at a single point. We will study this mechanism for creating clustering and will address the existence of limiting Extreme Value Laws, the repercussions on the value of the Extremal Index, the impact on the limit of Rare Events Points Processes, the influence on clustering patterns and the competition of domains of attraction. We also consider briefly and for comparison purposes multiple uncorrelated maxima. The systems considered include expanding maps of the interval such as Rychlik maps but also maps with an indifferent fixed point such as Manneville-Pommeau maps.
The incidence, risk factors, and outcomes associated with late right-sided heart failure in patients supported with an axial-flow left ventricular assist device
Creators: name: Lee, Sangjin
name: Eckman, Peter M.
name: Rich, Jonathan D.
name: Gosev, Igor
name: Kiernan, Michael
name: Uriel, Nir
name: Joseph, Susan
name: Patel, Chetan B.
name: Kilic, Ahmet
name: Bethea, Brian
name: Katz, Jason N.
name: Soleimani, Behzad
name: Sundareswaran, Kartik
name: Lima, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: BACKGROUND: Early right-sided heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with increased mortality, but little is known about patients who develop late RHF (LRHF). We evaluated the incidence, risk factors, and clinical impact of LRHF in patients supported by axial-flow LVADs.

METHODS: Data were analyzed from 537 patients enrolled in the HeartMate II (HM II; Thoratec/St. Jude) destination therapy clinical trial. LRHF was defined as the development of clinical RHF accompanied by the need for inotropic support occurring more than 30 days after discharge from the index LVAD implant hospitalization. Clinical variables, quality of life, rehospitalizations, and survival were compared between patients with and without LRHF.

RESULTS: LRHF developed in 41 patients (8%), with a median time to LRHF of 480 days. A higher preoperative blood urea nitrogen and increased central venous pressure-to-pulmonary capillary wedge pressure ratio were independent predictors of LRHF. The Michigan and HMII RHF risk scores were both associated with an increased likelihood of LRHF (p < 0.05). Patients with LRHF had worse quality of life according to the Kansas City Cardiomyopathy Questionnaire (61 ± 26 vs 70 ± 21; p < 0.05), poorer functional capacity by 6-minute walk distance (275 ± 189 m vs 312 ± 216 m; p < 0.05), and more rehospitalizations (6 vs 3; p < 0.001). LRHF was associated with decreased survival (p < 0.001).

CONCLUSIONS: LRHF is an important complication in patients with LVADs and is associated with worse quality of life, reduced functional capacity, more frequent hospitalizations, and worse survival compared with those without LRHF.
Scattering theory approach to bosonization of non-equilibrium mesoscopic systems
Creators: name: Sukhorukov, Eugene V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Between many prominent contributions of Markus Buttiker to mesoscopic physics, the scattering theory approach to the electron transport and noise stands out for its elegance, simplicity, universality, and popularity between theorists working in this field. It offers an efficient way to theoretically investigate open electron systems far from equilibrium. However, this method is limited to situations where interactions between electrons can be ignored, or considered perturbatively. Fortunately, this is the case in a broad class of metallic systems, which are commonly described by the Fermi liquid theory. Yet, there exist another broad class of electron systems of reduced dimensionality, the so-called Tomonaga-Luttinger liquids, where interactions are effectively strong and cannot be neglected even at low energies. Nevertheless, strong interactions can be accounted exactly using the bosonization technique, which utilizes the free-bosonic character of collective excitations in these systems. In the present work, we use this fact in order to develop the scattering theory approach to the bosonization of open quasi-one dimensional electron systems far from equilibrium.
description: New and improved final version. Contribution to a special issue of Physica E in memory of Markus Buttiker
Early intervention for lactate dehydrogenase elevation improves clinical outcomes in patients with the HeartMate II left ventricular assist device: Insights from the PREVENT study
Creators: name: Keebler, Mary E.
name: John, Ranjit
name: Chuang, Joyce
name: Stulak, John M.
name: Gregoric, Igor
name: Emani, Sitaramesh
name: Sundareswaran, Kartik S.
name: Eckman, Peter
name: Maltais, Simon
name: Adler, Eric
name: Uriel, Nir
name: Farrar, David J.
name: Agarwal, Richa
name: Katz, Jason N.
name: Thenappan, Thenappan
name: Shah, Palak
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: BACKGROUND: Hemolysis, assessed by elevated serum lactate dehydrogenase (LDH), is strongly associated with HeartMate II pump thrombosis (PT). However, it is unknown whether early intervention for elevated LDH circumvents the risk of serious PT requiring pump exchange. We sought to evaluate the relationship between elevated LDH and clinical outcomes, the effectiveness of early medical intervention, and risk factors for elevated LDH.

METHODS: We studied 268 patients in the prospective, multicenter PREVENT study who had 2 or more LDH measurements at ≥30 days post-implant. Elevated LDH was defined as LDH ≥2.5× upper limit of normal (ULN) for 2 consecutive measurements.

RESULTS: Fourteen percent of patients had elevated LDH. Stroke-free survival at 6 months was lower in patients with elevated LDH vs patients with normal LDH (83 ± 6% vs 93 ± 2%, p = 0.035). Elevated LDH resolved without intervention in 19% of patients, with intensified medical therapy in 43% and required surgical intervention in 38%. For patients receiving only medical therapy, survival was 94 ± 6% at 6 months post-treatment. In this subgroup, resolution of symptoms with intensified medical therapy was sustained in 15 of 16 patients, with PT occurring in 1 patient at 171 days after initial treatment for elevated LDH (202 days post-implant). Early medical intervention at moderately elevated LDH (2.5× to 3.2× ULN), as compared with higher levels (>3.2× ULN), led to more sustained resolution of symptoms without subsequent PT or need for surgical intervention (91% vs 26% at 6 months post-treatment, p = 0.002).

CONCLUSIONS: Early medical intervention can successfully resolve moderate LDH elevations (2.5× to 3.2× ULN) with a low incidence of death or PT at 6 months post-treatment.
Characterization of thermal decomposition of oxygenated organic compounds in FIGAERO-CIMS
Creators: name: Yang, Laura Hyesung
name: Takeuchi, Masayuki
name: Chen, Yunle
name: Ng, Nga Lee
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The Filter Inlet for Gases and AEROsols coupled with a chemical ionization mass spectrometer (FIGAERO-CIMS) measures particle-phase organics via temperature-programmed thermal desorption, though the extent to which different compounds undergo thermal decomposition is not well characterized. We study the effect of functional groups on the degree and pathways (decarboxylation and dehydration) of thermal decomposition in FIGAERO-CIMS using atmospherically relevant alcohols, monoacids, diacids, polyacids, and multifunctional acids. Based on their carbon oxidation state, compounds are categorized as less-oxidized oxygenated organic aerosol (LO-OOA), oxygenated organic aerosol (OOA), or more-oxidized OOA (MO-OOA), and exhibit little, minor, and considerable thermal decomposition, respectively. The result shows that thermal decomposition leads to negative biases in the measured elemental ratios (O:C and H:C) of compounds categorized as OOA and MO-OOA, except for the H:C ratio of those categorized as MO-OOA. We develop screening criteria for considerable thermal decomposition using double bond equivalent (DBE), maximum desorption temperature (Tmax), and the number of oxygen (nO) (DBE ≥ 2, Tmax ≥ 72 °C, and nO > 4). Additionally, we find that β-keto-carboxylic acids and carboxyl-containing aromatic compounds are the only compounds that favor decarboxylation. Lastly, we investigate the effect of the instrument’s temperature ramping rate (40, 13.3, and 3.3 °C min−1) on the thermal decomposition using citric acid. We recommend using 13.3 and 40 °C min−1 ramping rates but do not recommend using 3.3 °C min−1 which acts distinctively from 13.3 and 40 °C min−1 with the most parental compound decomposition. Copyright © 2021 American Association for Aerosol Research
Universal Superconductivity in FeTe and All-Iron-Based Ferromagnetic Superconductor Heterostructures
Creators: name: Yi, Hee Taek
name: Yao, Xiong
name: Jain, Deepti
name: Chan, Ying-Ting
name: Chen, An-Hsi
name: Brahlek, Matthew
name: Kisslinger, Kim
name: Du, Kai
name: Han, Myung-Geun
name: Zhu, Yimei
name: Wu, Weida
name: Cheong, Sang-Wook
name: Oh, Seongshik
Publisher: name: arXiv
Year: 2025
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Ferromagnetism (FM) and superconductivity (SC) are two of the most famous macroscopic quantum phenomena. However, nature normally does not allow SC and FM to coexist without significant degradation. Here, we introduce the first fully iron-based SC/FM heterostructures, composed of Fe(Te,Se) and Fe3GeTe2, and show that in this platform strong FM and high-temperature SC robustly coexist. We subsequently discover that chemical proximity effect from neighboring layers can universally drive the otherwise non-superconducting FeTe films into a SC state. This suggests that the ground state of FeTe is so close to the SC state that it could be driven in and out of the SC state with various other perturbations. Altogether, this shows that Fe-Te-based heterostructures provide a unique opportunity to manipulate magnetism, superconductivity and topological physics, paving the way toward new superconducting technologies.
Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration
Creators: name: Tisch, Roland
name: Zhang, Rui
name: Burridge, Keith
name: Clark, Matthew
name: Morillon, Y. Maurice
name: Wang, Bo
name: Lessey-Morillon, Elizabeth Chase
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The use of nondepleting Ab specific for CD4 and CD8 is an effective strategy to tolerize CD4+ and CD8+ T cells in a tissue-specific manner. We reported that coreceptor therapy reverses diabetes in new onset NOD mice. A striking feature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN) and islets of NOD mice. Evidence indicates that Ab binding to the coreceptors promotes T cell egress from these tissues. The current study examined how coreceptor therapy affects the migration of CD4+ T cells residing in the PLN of NOD mice. αCD4 Ab treatment resulted in an increased frequency of PLN but not splenic CD4+ T cells that exhibited a polarized morphology consistent with a migratory phenotype. Furthermore, PLN CD4+ T cells isolated from αCD4 versus control Ab-treated animals displayed increased in vitro chemotaxis to chemoattractants such as sphingosine-1-phosphate and CXCL12. Notably, the latter was dependent on activation of the small Rho GTPases Rac1 and Rac2. Rac1 and Rac2 activation was increased in Ab-bound CD4+ T cells from the PLN but not the spleen, and knockdown of Rac expression blocked the heightened reactivity of Ab-bound PLN CD4+ T cells to CXCL12. Interestingly, Rac1 and Rac2 activation was independent of Rac guanine nucleotide exchange factors known to regulate T cell activity. Therefore, Ab binding to CD4 initiates a novel pathway that involves inflammation-dependent activation of Rac, and establishment of altered T cell migratory properties.
Correspondence Truth and Quantum Mechanics
Creators: name: Karakostas, Vassilios
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: The logic of a physical theory reflects the structure of the propositions referring to the behaviour of a physical system in the domain of the relevant theory. It is argued in relation to classical mechanics that the propositional structure of the theory allows truth-value assignment in conformity with the traditional conception of a correspondence theory of truth. Every proposition in classical mechanics is assigned a definite truth value, either 'true' or 'false', describing what is actually the case at a certain moment of time. Truth-value assignment in quantum mechanics, however, differs; it is known, by means of a variety of 'no go' theorems, that it is not possible to assign definite truth values to all propositions pertaining to a quantum system without generating a Kochen-Specker contradiction. In this respect, the Bub-Clifton 'uniqueness theorem' is utilized for arguing that truth-value definiteness is consistently restored with respect to a determinate sublattice of propositions defined by the state of the quantum system concerned and a particular observable to be measured. An account of truth of contextual correspondence is thereby provided that is appropriate to the quantum domain of discourse. The conceptual implications of the resulting account are traced down and analyzed at length. In this light, the traditional conception of correspondence truth may be viewed as a species or as a limit case of the more generic proposed scheme of contextual correspondence when the non-explicit specification of a context of discourse poses no further consequences.
description: 19 pages
Reducing COVID-19 airborne transmission risks on public transportation buses: an empirical study on aerosol dispersion and control
Creators: name: Edwards, Nathan J.
name: Widrick, Rebecca
name: Wilmes, Justin
name: Breisch, Ben
name: Gerschefske, Mike
name: Sullivan, Jon
name: Potember, Richard
name: Espinoza-Calvio, Angelica
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This study is one of the first COVID-19 related bus studies to fully characterize cough aerosol dispersion and control in the highly turbulent real-world environment of driving regular bus routes on both a school bus and a transit bus. While several other bus studies have been conducted, they were limited to clinical contact tracing, simulation, or partial characterization of aerosol transmission in the passenger areas with constraint conditions. When considering the risk of transmission of SARS-CoV-2 (COVID-19) and other highly infectious airborne diseases, ground based public transportation systems are high-risk environments for airborne transmission particularly since social distancing of six feet is not practical on most buses. This study demonstrates that wearing of masks reduced the overall particle count released into the bus by an average of 50% or more depending on mask quality and reduced the dispersion distance by several feet. The study also demonstrates an 84.36% reduction in aerosol particles and an 80.28% reduction in the mean aerosol residence time for some test cases. We conducted 84 experimental runs using nebulized 10% sodium chloride and a mechanical exhalation simulator that resulted in 78.3 million data points and 124 miles of on-the-road testing. Our study not only captures the dispersion patterns using 28 networked particle counters, it also quantifies the effectiveness of using on-board fans, opening of various windows, use of face coverings or masks, and the use of the transit bus HVAC system. This work additionally provides empirical observations of aerosol dispersion in a real-world turbulent air environment, which are remarkably different than many existing fluid dynamics simulations, and also offers substantial discussion on the implications for inclement weather conditions, driver safety, retrofit applications to improve bus air quality, and operational considerations for public transportation organizations.
Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus
Creators: name: Schmitz, John
name: Fedoriw, Yuri
name: Truong, Young K.
name: Vilen, Barbara J.
name: Diaz, Marilyn
name: Rogers, Jennifer L.
name: Clarke, Stephen H.
name: Kang, Sunah
name: Jiang, Chuancang
name: Monteith, Andrew J.
name: Tarrant, Teresa K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Apoptotic debris, autoantibody, and IgG-immune complexes (ICs) have long been implicated in the inflammation associated with systemic lupus erythematosus (SLE); however, it remains unclear whether they initiate immune-mediated events that promote disease. In this study, we show that peripheral blood mononuclear cells from SLE patients experiencing active disease, and hematopoietic cells from lupus-prone MRL/lpr and NZM2410 mice accumulate markedly elevated levels of surface-bound nuclear self-antigens. On dendritic cells (DCs) and macrophages (MFs), the self-antigens are part of IgG-ICs that promote FcγRI-mediated signal transduction. Accumulation of IgG-ICs is evident on ex vivo myeloid cells from MRL/lpr mice by 10 weeks of age, and steadily increases prior to lupus nephritis. IgG and FcγRI play a critical role in disease pathology. Passive transfer of pathogenic IgG into IgG-deficient MRL/lpr mice promotes the accumulation of IgG-ICs prior to significant B cell expansion, BAFF secretion, and lupus nephritis. In contrast, diminishing the burden IgG-ICs in MRL/lpr mice through deficiency in FcγRI markedly improves these lupus pathologies. Together, our findings reveal a previously unappreciated role for the cell surface accumulation of IgG-ICs in human and murine lupus.
Characterization of Thermal Decomposition of Oxygenated Organic Compounds in FIGAERO-CIMS
Creators: name: Yang, Laura Hyesung
name: Takeuchi, Masayuki
name: Chen, Yunle
name: Ng, Nga Lee
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Inorganic Chemistry
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The Filter Inlet for Gases and AEROsols coupled with a chemical ionization mass spectrometer (FIGAERO-CIMS) measures particle-phase organics via temperature-programmed thermal desorption, though the extent to which different compounds undergo thermal decomposition is not well characterized. We study the effect of functional groups on the degree and pathways (decarboxylation and dehydration) of thermal decomposition in FIGAERO-CIMS using atmospherically relevant alcohols, monoacids, diacids, polyacids, and multifunctional acids. Based on their carbon oxidation state, compounds are categorized as less-oxidized oxygenated organic aerosols (LO-OOA), OOA, or more-oxidized OOA (MO-OOA), and exhibit little, minor, and considerable thermal decomposition, respectively. The result shows that thermal decomposition leads to negative biases in the measured elemental ratios (O:C and H:C) of compounds categorized as OOA and MO-OOA, except for the H:C ratio of those categorized as MO-OOA. We develop screening criteria for considerable thermal decomposition using double bond equivalent (DBE), maximum desorption temperature (Tmax), and the number of oxygen (nO) (DBE ≥ 2, Tmax ≥ 72 °C, and nO >4). Additionally, we find that β-keto-carboxylic acid and carboxyl-containing aromatic compounds are the only compounds that favor decarboxylation. Lastly, we investigate the effect of the instrument’s temperature ramping rate (40, 13.3, and 3.3 °C min−1) on the thermal decomposition using citric acid. We recommend using 13.3 and 40 °C min−1 ramping rates but do not recommend using 40 °C min−1 which acts distinctively from 13.3 and 40 °C min−1 with the most parental compound decomposition.
Reducing COVID-19 Airborne Transmission Risks on Public Transportation Buses: An Empirical Study on Aerosol Dispersion and Control
Creators: name: Edwards, Nathan J.
name: Widrick, Rebecca
name: Wilmes, Justin
name: Breisch, Ben
name: Gerschefske, Mike
name: Sullivan, Jon
name: Potember, Richard
name: Espinoza-Calvio, Angelica
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This study is one of the first COVID-19 related bus studies to fully characterize cough aerosol dispersion and control in the highly turbulent real-world environment of driving regular bus routes on both a school bus and a transit bus. While several other bus studies have been conducted, they were limited to clinical contact tracing, simulation, or partial characterization of aerosol transmission in the passenger areas with constraint conditions. When considering the risk of transmission of SARS-CoV-2 (COVID-19) and other highly infectious airborne diseases, ground based public transportation systems are high-risk environments for airborne transmission particularly since social distancing of six feet is not practical on most buses. This study demonstrates that wearing of masks reduced the overall particle count released into the bus by an average of 50% or more depending on mask quality and reduced the dispersion distance by several feet. The study also demonstrates an 84.36% reduction in aerosol particles and an 80.28% reduction in the mean aerosol residence time for some test cases. We conducted 84 experimental runs using nebulized 10% sodium chloride and a mechanical exhalation simulator that resulted in 78.3 million data points and 124 miles of on-the-road testing. Our study not only captures the dispersion patterns using 28 networked particle counters, as well as quantifies the effectiveness of using on-board fans, opening of various windows, use of face coverings or masks, and the use of the transit bus HVAC system. This work also provides empirical observations of aerosol dispersion in a real-world turbulent air environment, which are remarkably different than many existing fluid dynamics simulations, and also offers substantial discussion on the implications for inclement weather conditions, driver safety, retrofit applications to improve bus air quality, and operational considerations for public transportation organizations.
Optical observations of the luminous Type IIn Supernova 2010jl for over 900 days
Creators: name: Jencson, J. E.
name: Prieto, J. L.
name: Kochanek, C. S.
name: Shappee, B. J.
name: Stanek, K. Z.
name: Pogge, R. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The luminous Type IIn Supernova (SN) 2010jl shows strong evidence for the interaction of the SN ejecta with dense circumstellar material (CSM). We present observations of SN 2010jl for $t \sim 900$ d after its earliest detection, including a sequence of optical spectra ranging from $t = 55$ to $909$ d. We also supplement our late time spectra and the photometric measurements in the literature with an additional epoch of new, late time $BVRI$ photometry. Combining available photometric and spectroscopic data, we derive a semi-bolometric optical light curve and calculate a total radiated energy in the optical for SN 2010jl of $\sim 3.5\times10^{50}$ erg. We also examine the evolution of the H$α$ emission line profile in detail and find evidence for asymmetry in the profile for $t \gtrsim 775$ d that is not easily explained by any of the proposed scenarios for this fascinating event. Finally, we discuss the interpretations from the literature of the optical and near-infrared light curves, and propose that the most likely explanation of their evolution is the formation of new dust in the dense, pre-existing CSM wind after $\sim 300$ d.
description: 14 pages, 10 figures, 5 tables. Full version of Table 3 is included as an ancillary file
BPTF Is Essential for T Cell Homeostasis and Function
Creators: name: Wang, Chaojun
name: Wan, Yisong Y.
name: Wang, Yunqi
name: Wang, Gang Greg
name: Wu, Jie
name: Wu, Bing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Bromodomain PHD Finger Transcription Factor (BPTF), a ubiquitously expressed ATP-dependent chromatin-remodeling factor, is critical for epigenetically regulating DNA accessibility and gene expression. While BPTF is important for the development of thymocytes, its function in mature T cells remains largely unknown. By specifically deleting BPTF from late DN3/DN4 stage of developing T cells, we found that BPTF was critical for the homeostasis of T cells via a cell intrinsic manner. In addition, BPTF was essential for the maintenance and function of Treg cells. Treg cell-specific BPTF deletion led to reduced Foxp3 expression, increased lymphocyte infiltration in the non-lymphoid organs and a systemic autoimmune syndrome. These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.
Direct imaging of AGN outflows and their origin with the 23 m Large Binocular Telescope
Creators: name: Isbell, Jacob W.
name: Ertel, Steve
name: Pott, Jörg-Uwe
name: Weigelt, Gerd
name: Stalevski, Marko
name: Leftley, James
name: Jaffe, Walter
name: Petrov, Romain G.
name: Moszczynski, Niklas
name: Vermot, Pierre
name: Hinz, Philip
name: Burtscher, Leonard
name: Rosas, Violeta Gámez
name: Becker, Alexander
name: Carlson, Jared
name: Faramaz-Gorka, Virginie
name: Hoffmann, William F.
name: Leisenring, Jarron
name: Power, Jennifer
name: Wagner, Kevin
Publisher: name: arXiv
Year: 2025
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Active galactic nuclei (AGNs) are a key component of galaxy evolution due to feedback on the host from its supermassive black hole. The morphology of warm, in- and outflowing dusty material can reveal the nature of the onset of feedback, AGN feeding, and the unified model of AGN. Here we use the Large Binocular Telescope Interferometer (LBTI) to image the dense, obscuring disk and extended dusty outflow region of NGC 1068. In Fizeau imaging mode the LBTI synthesizes the equivalent resolution of a 22.8 m telescope. The 8.7 $μ$m Fizeau images of NGC 1068 {have an effective resolution of $47\times90$ mas ($3.3\times6.2$ pc)} in a 5" field of view after performing PSF deconvolution techniques described here. This is the only extragalactic source to be Fizeau imaged using the LBTI, and the images bridge the scales measured with the Very Large Telescope Interferometer (VLTI; 0.5-5 pc) and those of single telescopes such as JWST and Keck ($>15$ pc). The images detect and spatially resolve the low surface brightness mid-infrared (MIR) features in the AGN disk/wind region that are over-resolved by the VLTI. The images show strong correlation between MIR dust emission and near-infrared (NIR) emission of highly excited atomic lines observed by SINFONI. Such LBTI imaging is a precursor to infrared imaging using the upcoming generation of extremely large telescopes, with angular resolutions up to 6x better than JWST, the largest space telescope in orbit.
description: 26 Pages, Accepted for publication in Nature Astronomy
Clearing Persistent Extracellular Antigen of Hepatitis B Virus: An Immunomodulatory Strategy To Reverse Tolerance for an Effective Therapeutic Vaccination
Creators: name: Peng, Hua
name: Yang, Dan
name: Bian, Yingjie
name: He, Junming
name: Zhang, Liguo
name: Sun, Zhichen
name: Zhu, Danming
name: Su, Lishan
name: Fu, Sherry
name: Liu, Longchao
name: Fu, Yang-Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Development of therapeutic vaccines/strategies to control chronic hepatitis B virus (HBV) infection (CHB) has been challenging due to HBV-induced tolerance. In this study, we explored strategies for breaking tolerance and restoring the immune response to the HBV surface antigen in tolerant mice. We demonstrated that immune tolerance status is attributed to the level and duration of circulating HBsAg in HBV carrier models. Removal of circulating HBsAg by a monoclonal anti-HBsAg antibody in tolerant mice could gradually reduce tolerance and reestablish B cell and CD4+ T cell responses to subsequent Engerix-B vaccination, producing protective IgG. Furthermore, HBsAg-specific CD8+ T cells induced by the addition of a TLR agonist, resulted in clearance of HBV in both serum and liver. Thus, generation of protective immunity can be achieved by clearing extracellular viral antigen with neutralizing antibodies followed by vaccination.
Moving contact line dynamics: from diffuse to sharp interfaces
Creators: name: Kusumaatmaja, Halim
name: Hemingway, Ewan J.
name: Fielding, Suzanne M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Computational Physics (physics.comp-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We reconcile two scaling laws that have been proposed in the literature for the slip length associated with a moving contact line in diffuse interface models, by demonstrating each to apply in a different regime of the ratio of the microscopic interfacial width $l$ and the macroscopic diffusive length $l_D= (Mη)^{1/2}$, where $η$ is the fluid viscosity and $M$ the mobility governing intermolecular diffusion. For small $l_D/l$ we find a diffuse interface regime in which the slip length scales as $ξ\sim(l_Dl)^{1/2}$. For larger $l_D/l>1$ we find a sharp interface regime in which the slip length depends only on the diffusive length, $ξ\sim l_D \sim (Mη)^{1/2}$, and therefore only on the macroscopic variables $η$ and $M$, independent of the microscopic interfacial width $l$. We also give evidence that modifying the microscopic interfacial terms in the model's free energy functional appears to affect the value of the slip length only the diffuse interface regime, consistent with the slip length depending only on macroscopic variables in the sharp interface regime. Finally, we demonstrate the dependence of the dynamic contact angle on the capillary number to be in excellent agreement with the theoretical prediction of \cite{Cox1986}, provided we allow the slip length to be rescaled by a dimensionless prefactor. This prefactor appears to converge to unity in the sharp interface limit, but is smaller in the diffuse interface limit. The excellent agreement of results obtained using three independent numerical methods, across several decades of the relevant dimensionless variables, demonstrates our findings to be free of numerical artifacts.
description: 24 pages, 5 figures