Rationale and plan for vitamin D food fortification: A review and guidance paper
Creators: name: Pilz, Stefan
name: März, Winfried
name: Cashman, Kevin D.
name: Kiely, Mairead E.
name: Whiting, Susan J.
name: Holick, Michael F.
name: Grant, William B.
name: Pludowski, Pawel
name: Hiligsmann, Mickael
name: Trummer, Christian
name: Schwetz, Verena
name: Lerchbaum, Elisabeth
name: Pandis, Marlene
name: Tomaschitz, Andreas
name: Grübler, Martin R.
name: Gaksch, Martin
name: Verheyen, Nicolas
name: Hollis, Bruce W.
name: Rejnmark, Lars
name: Karras, Spyridon N.
name: Hahn, Andreas
name: Bischoff-Ferrari, Heike A.
name: Reichrath, Jörg
name: Jorde, Rolf
name: Elmadfa, Ibrahim
name: Vieth, Reinhold
name: Scragg, Robert
name: Calvo, Mona S.
name: Van Schoor, Natasja M.
name: Bouillon, Roger
name: Lips, Paul
name: Itkonen, Suvi T.
name: Martineau, Adrian R.
name: Lamberg-Allardt, Christel
name: Zittermann, Armin
Publisher: name: Lausanne : Frontiers Media S.A.
Year: 2018
Subjects: subject: Evidence
subject: Food fortification
subject: General population
subject: Guidelines
subject: Policy
subject: Public health
subject: Recommendations
subject: Vitamin D
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas intake by nutrition traditionally plays a relatively minor role. Dietary guidelines for vitamin D are based on a consensus that serum 25-hydroxyvitamin D (25[OH]D) concentrations are used to assess vitamin D status, with the recommended target concentrations ranging from ≥25 to ≥50 nmol/L (≥10-≥20 ng/mL), corresponding to a daily vitamin D intake of 10 to 20 μg (400-800 international units). Most populations fail to meet these recommended dietary vitamin D requirements. In Europe, 25(OH)D concentrations &lt; 30 nmol/L (12 ng/mL) and &lt; 50 nmol/L (20 ng/mL) are present in 13.0 and 40.4% of the general population, respectively. This substantial gap between officially recommended dietary reference intakes for vitamin D and the high prevalence of vitamin D deficiency in the general population requires action from health authorities. Promotion of a healthier lifestyle with more outdoor activities and optimal nutrition are definitely warranted but will not erase vitamin D deficiency and must, in the case of sunlight exposure, be well balanced with regard to potential adverse effects such as skin cancer. Intake of vitamin D supplements is limited by relatively poor adherence (in particular in individuals with low-socioeconomic status) and potential for overdosing. Systematic vitamin D food fortification is, however, an effective approach to improve vitamin D status in the general population, and this has already been introduced by countries such as the US, Canada, India, and Finland. Recent advances in our knowledge on the safety of vitamin D treatment, the dose-response relationship of vitamin D intake and 25(OH)D levels, as well as data on the effectiveness of vitamin D fortification in countries such as Finland provide a solid basis to introduce and modify vitamin D food fortification in order to improve public health with this likewise cost-effective approach.