cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Disentangling the jet emission from protostellar systems. The ALMA view of VLA1623
Creators: name: Santangelo, G.
name: Murillo, N. M.
name: Nisini, B.
name: Codella, C.
name: Bruderer, S.
name: Lai, S. -P.
name: van Dishoeck, E. F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context: High-resolution studies of class 0 protostars represent the key to constraining protostar formation models. VLA16234-2417 represents the prototype of class 0 protostars, and it has been recently identified as a triple non-coeval system. Aim: We aim at deriving the physical properties of the jets in VLA16234-2417 using tracers of shocked gas. Methods: ALMA Cycle 0 Early Science observations of CO(2-1) in the extended configuration are presented in comparison with previous SMA CO(3-2) and Herschel-PACS [OI}] 63 micron observations. Gas morphology and kinematics were analysed to constrain the physical structure and origin of the protostellar outflows. Results: We reveal a collimated jet component associated with the [OI] 63 micron emission at about 8'' (about 960 AU) from source B. This newly detected jet component is inversely oriented with respect to the large-scale outflow driven by source A, and it is aligned with compact and fast jet emission very close to source B (about 0.3'') rather than with the direction perpendicular to the A disk. We also detect a cavity-like structure at low projected velocities, which surrounds the [OI] 63 micron emission and is possibly associated with the outflow driven by source A. Finally, no compact outflow emission is associated with source W. Conclusions: Our high-resolution ALMA observations seem to suggest there is a fast and collimated jet component associated with source B. This scenario would confirm that source B is younger than A, that it is in a very early stage of evolution, and that it drives a faster, more collimated, and more compact jet with respect to the large-scale slower outflow driven by A. However, a different scenario of a precessing jet driven by A cannot be firmly excluded from the present observations.
description: Accepted for publication in Astronomy & Astrophysics
RECHAUFFEMENT GLOBAL : QUI, DU CO2 OU DE LA TEMPERATURE PRECEDE L’AUTRE ? CATASTROPHISME VERSUS UNIFORMITARISME
Creators: name: Bourgois, Jacques
Publisher: name: figshare
Year: 2022
Subjects: subject: Climate Science
subject: 40105 Climatology (excl. Climate Change Processes)
subject: FOS: Earth and related environmental sciences

description: Une réponse satisfaisante doit être apportée à la question, non résolue, de savoir qui du CO2 ou de la température précède l’autre. L’augmentation de la température doit être, en effet, postérieure à l’augmentation du CO2 pour envisager une origine anthropique (rejet massif de gaz à effet de serre par l’homme) comme cause principale du réchauffement global actuel.  
title: Impact of PET Ga-68 PSMA On Planning for Radical Radiotherapy Treatment of Prostate Cancer
Creators: name: Dickie, Graeme
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Genital / Reproductive system male
subject: Oncology
subject: Hybrid Imaging
subject: PET
subject: Radiation therapy / Oncology
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To assess how PSMA-PET scans have influenced management of patients with localised prostate cancer who were seen with a view to radical...
Sonnenfleckenzeichnung Nr. 86.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.04.2008, 09:00, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Linear magnetoresistance in metals: guiding center diffusion in a smooth random potential
Creators: name: Song, Justin C. W.
name: Refael, Gil
name: Lee, Patrick A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We predict that guiding center (GC) diffusion yields a linear and non-saturating (transverse) magnetoresistance in 3D metals. Our theory is semi-classical and applies in the regime where the transport time is much greater than the cyclotron period, and for weak disorder potentials which are slowly varying on a length scale much greater than the cyclotron radius. Under these conditions, orbits with small momenta along magnetic field $B$ are squeezed and dominate the transverse conductivity. When disorder potentials are stronger than the Debye frequency, linear magnetoresistance is predicted to survive up to room temperature and beyond. We argue that magnetoresistance from GC diffusion explains the recently observed giant linear magnetoresistance in 3D Dirac materials.
Sonnenfleckenzeichnung Nr. 151.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.07.2008, 07:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 269.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.11.2008, 08:45, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Anisotropic cosmology in $q$-deformed entropic gravity
Creators: name: Kibaroğlu, Salih
name: Senay, Mustafa
Publisher: name: arXiv
Year: 2025
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work, we examine the implications of $q$-deformed theory on anisotropic Bianchi type-I cosmological model within the framework of Verlinde's entropic gravity. The $q$-deformed theory, rooted in quantum group structures, provides a natural generalization of classical particle dynamics and offers a useful framework for exploring deviations in standard cosmological models. By incorporating the principles of entropic gravity, which conceptualize gravity as an emergent entropic force, we derive the dynamical equations governing the Bianchi type-I anisotropic model influenced by $q$-deformation. Finally, we analyze the axisymmetric solution of Bianchi type-I model and these findings highlight the potential impact of $q$-deformation on the dynamics of the early universe and its subsequent evolution.
description: 14 pages, 4 figures. To be published in Nuclear Physics B
Games for Dependent Types
Creators: name: Abramsky, Samson
name: Jagadeesan, Radha
name: Vákár, Matthijs
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We present a model of dependent type theory (DTT) with Pi-, 1-, Sigma- and intensional Id-types, which is based on a slight variation of the category of AJM-games and history-free winning strategies. The model satisfies Streicher's criteria of intensionality and refutes function extensionality. The principle of uniqueness of identity proofs is satisfied. We show it contains a submodel as a full subcategory which gives a faithful model of DTT with Pi-, 1-, Sigma- and intensional Id-types and, additionally, finite inductive type families. This smaller model is fully (and faithfully) complete with respect to the syntax at the type hierarchy built without Id-types, as well as at the class of types where we allow for one strictly positive occurrence of an Id-type. Definability for the full type hierarchy with Id-types remains to be investigated.
description: revised version of ICALP 2015 publication
Gomphrena vitellina Pedersen, Adansonia
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Caryophyllales
Amaranthaceae
Gomphrena
Gomphrena vitellina

description: Gomphrena vitellina Pedersen, Adansonia 12: 87. 1990.
Herb.
 Vouchers: Amambay: Ferrucci et al. 641, type (CTES, G, SI); Mereles 1473 (FCQ, G); Mereles 3265 (G).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Direct Modulation of Heterotrimeric G Protein-coupled Signaling by a Receptor Kinase Complex
Creators: name: Urano, Daisuke
name: Tunc-Ozdemir, Meral
name: Jones, Alan M.
name: Clouse, Steven D.
name: KumarJaiswal, Dinesh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Plants and some protists have heterotrimeric G protein complexes that activate spontaneously without canonical G protein-coupled receptors (GPCRs). In Arabidopsis, the sole 7-transmembrane regulator of G protein signaling 1 (AtRGS1) modulates the G protein complex by keeping it in the resting state (GDP-bound). However, it remains unknown how a myriad of biological responses is achieved with a single G protein modulator. We propose that in complete contrast to G protein activation in animals, plant leucine-rich repeat receptor-like kinases (LRR RLKs), not GPCRs, provide this discrimination through phosphorylation of AtRGS1 in a ligand-dependent manner. G protein signaling is directly activated by the pathogen-associated molecular pattern flagellin peptide 22 through its LRR RLK, FLS2, and co-receptor BAK1.
title: Discrepancies and Time Delay between Radiology Registrar Report of After-Hours Imaging and Report of the Checking Radiology Consultant in a South Australian Tertiary Hospital
Creators: name: Harty, Emily
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Quality assurance
subject: Education and training
subject: Education
subject: Complications
subject: Audit and standards
subject: Digital radiography
subject: CT
subject: Trauma
subject: Emergency
subject: Professional issues

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The aim of the after-hours Radiology service at Flinders Medical Centre is to identify any urgent or life-threatening imaging findings that may affect patient management overnight. The service is provided by radiology registrars with consultant...
title: Radiological Changes of the Lumbar Spine with Normal Ageing
Creators: name: Thai, Maxter
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Education and training
subject: Physiological studies
subject: Normal variants
subject: Education
subject: CT
subject: Musculoskeletal spine
subject: Musculoskeletal joint

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Describe the spectrum of visual changes seen in the normal ageing of the lumbar spine and its associated structures (intervertebral discs, spinal ligaments, spinal canal, intervertebral foramina, zygapophyseal joints). Illustrate these changes using...
Ancilla-driven quantum computation for qudits and continuous variables
Creators: name: Proctor, Timothy
name: Giulian, Melissa
name: Korolkova, Natalia
name: Andersson, Erika
name: Kendon, Viv
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Although qubits are the leading candidate for the basic elements in a quantum computer, there are also a range of reasons to consider using higher dimensional qudits or quantum continuous variables (QCVs). In this paper we use a general `quantum variable' formalism to propose a method of quantum computation in which ancillas are used to mediate gates on a well-isolated `quantum memory' register and which may be applied to the setting of qubits, qudits (for $d>2$) or QCVs. More specifically, we present a model in which universal quantum computation may be implemented on a register using only: repeated applications of a single fixed two-body ancilla-register interaction gate, ancillas prepared in a single state, and local measurements of these ancillas. In order to maintain determinism in the computation, adaptive measurements via a classical-feedforward of measurement outcomes are used, with the method similar to that in measurement-based quantum computation (MBQC). We show that our model has the same hybrid quantum-classical processing advantages as MBQC, including the power to implement any Clifford circuit in essentially one layer of quantum computation. In some physical settings, high-quality measurements of the ancillas may be highly challenging or not possible, and hence we also present a globally unitary model which replaces the need for measurements of the ancillas with the requirement for ancillas to be prepared in states from a fixed orthonormal basis. Finally, we discuss settings in which these models may be of practical interest.
description: Final version. Minor updates from v2
Majorana boundary modes in Josephson junctions arrays with gapless bulk excitations
Creators: name: Pino, M.
name: Tsvelik, A. M.
name: Ioffe, L. B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The search for Majorana bound states in solid-state physics has been limited to materials which display a gap in their bulk spectrum. We show that such unpaired states appear in certain quasi-one-dimensional Josephson junctions arrays with gapless bulk excitations. The bulk modes mediate a coupling between Majorana bound states via the Ruderman-Kittel-Yosida-Kasuya mechanism. As a consequence, the lowest energy doublet acquires a finite energy difference. For realistic set of parameters this energy splitting remains much smaller than the energy of the bulk eigenstates even for short chains of length $L \sim 10$.
description: 5 pages
Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells
Creators: name: Rubin, Janet
name: Meyer, Mark B.
name: Sen, Buer
name: Benkusky, Nancy A.
name: Pike, J. Wesley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade of activated transcription factors and epigenetic modifications that drive gene transcription responsible for unique cell fate. Within the mesenchymal lineage, factors such as RUNX2 and PPARγ are indispensable for osteogenesis and adipogenesis, respectively. We therefore investigated genomic binding of transcription factors and accompanying epigenetic modifications that occur during osteogenic and adipogenic differentiation of mouse bone marrow-derived mesenchymal stem cells (MSCs). As assessed by ChIP-sequencing and RNA-sequencing analyses, we found that genes vital for osteogenic identity were linked to RUNX2, C/EBPβ, retinoid X receptor, and vitamin D receptor binding sites, whereas adipocyte differentiation favored PPARγ, retinoid X receptor, C/EBPα, and C/EBPβ binding sites. Epigenetic marks were clear predictors of active differentiation loci as well as enhancer activities and selective gene expression. These marrow-derived MSCs displayed an epigenetic pattern that suggested a default preference for the osteogenic pathway; however, these patterns were rapidly altered near the Adipoq, Cidec, Fabp4, Lipe, Plin1, Pparg, and Cebpa genes during adipogenic differentiation. Surprisingly, we found that these cells also exhibited an epigenetic plasticity that enabled them to trans-differentiate from adipocytes to osteoblasts (and vice versa) after commitment, as assessed by staining, gene expression, and ChIP-quantitative PCR analysis. The osteogenic default pathway may be subverted during pathological conditions, leading to skeletal fragility and increased marrow adiposity during aging, estrogen deficiency, and skeletal unloading. Taken together, our data provide an increased mechanistic understanding of the epigenetic programs necessary for multipotent differentiation of MSCs that may prove beneficial in the development of therapeutic strategies.
Eryngium plantaginifolium H. Wolff, Bot. Jahrb. Syst.
Creators: name: Chocarro, María Del Carmen Peña
name: Egea, Juana De
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Apiales
Apiaceae
Eryngium
Eryngium plantaginifolium

description: Eryngium plantaginifolium H.Wolff, Bot. Jahrb. Syst. 40(3): 297. 1908.
Herb.
 Vouchers: Amambay: Rojas 6646 (AS); Rojas 9935 (BM, LIL, K). Caaguazú: Hassler 9301, type (BM, G, NY); Hassler 9561, type (BM, F, G, GH, K, MPU, NY, P, S).
description: Published as part of Chocarro, María Del Carmen Peña & Egea, Juana De, 2018, Checklist of the endemic vascular plants of Paraguay, pp. 448-450 in Phytotaxa 384 (1) on pages 448-450, DOI: 10.11646/phytotaxa.384.1.1, http://zenodo.org/record/13725946
Sonnenfleckenzeichnung Nr. 213.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 06.09.2008, 07:30, erstellt von Marco Cagnotti
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
The analog Resistive Plate Chamber detector of the ARGO-YBJ experiment
Creators: name: Bartoli, B.
name: Bernardini, P.
name: Bi, X. J.
name: Cao, Z.
name: Catalanotti, S.
name: Chen, S. Z.
name: Chen, T. L.
name: Cui, S. W.
name: Dai, B. Z.
name: D'Amone, A.
name: Danzengluobu
name: De Mitri, I.
name: Piazzoli, B. D'Ettorre
name: Di Girolamo, T.
name: Di Sciascio, G.
name: Feng, C. F.
name: Feng, Zhaoyang
name: Feng, Zhenyong
name: Gou, Q. B.
name: Guo, Y. Q.
name: He, H. H.
name: Hu, Haibing
name: Hu, Hongbo
name: Iacovacci, M.
name: Iuppa, R.
name: Jia, H. Y.
name: Labaciren
name: Li, H. J.
name: Liu, C.
name: Liu, J.
name: Liu, M. Y.
name: Lu, H.
name: Ma, L. L.
name: Ma, X. H.
name: Mancarella, G.
name: Mari1, S. M.
name: Marsella, G.
name: Mastroianni, S.
name: Montini, P.
name: Ning, C. C.
name: Perrone, L.
name: Pistilli, P.
name: Salvini1, P.
name: Santonico, R.
name: Shen, P. R.
name: Sheng, X. D.
name: Shi, F.
name: Surdo, A.
name: Tan, Y. H.
name: Vallania, P.
name: Vernetto, S.
name: Vigorito, C.
name: Wang, H.
name: Wu, C. Y.
name: Wu, H. R.
name: Xue, L.
name: Yang, Q. Y.
name: Yang, X. C.
name: Yao, Z. G.
name: Yuan, A. F.
name: Zha, M.
name: Zhang, H. M.
name: Zhang, L.
name: Zhang, X. Y.
name: Zhang, Y.
name: Zhao, J.
name: Zhaxiciren
name: Zhaxisangzhu
name: Zhou, X. X.
name: Zhu, F. R.
name: Zhu, Q. Q.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The ARGO-YBJ experiment has been in stable data taking from November 2007 till February 2013 at the YangBaJing Cosmic Ray Observatory (4300 m a.s.l.). The detector consists of a single layer of Resistive Plate Chambers (RPCs) ( about 6700 m^2}) operated in streamer mode. The signal pick-up is obtained by means of strips facing one side of the gas volume. The digital readout of the signals, while allows a high space-time resolution in the shower front reconstruction, limits the measurable energy to a few hundred TeV. In order to fully investigate the 1-10 PeV region, an analog readout has been implemented by instrumenting each RPC with two large size electrodes facing the other side of the gas volume. Since December 2009 the RPC charge readout has been in operation on the entire central carpet (about 5800 m^2). In this configuration the detector is able to measure the particle density at the core position where it ranges from tens to many thousands of particles per m^2. Thus ARGO-YBJ provides a highly detailed image of the charge component at the core of air showers. In this paper we describe the analog readout of RPCs in ARGO-YBJ and discuss both the performance of the system and the physical impact on the EAS measurements.
title: Early Detection of Radiation Therapy Response in Glioblastoma Using Short Diffusion Time Diffusion Weighted MRI
Creators: name: Hau, Eric
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Oncology
subject: MR-Diffusion/Perfusion
subject: Radiobiology
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Glioblastomas are the most common and deadly primary brain tumour in adults The mostwidely used imaging criteria are based on two-dimensional tumour measurements on anatomical computed tomography (CT) or magnetic resonance imaging...
Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice
Creators: name: Jerome, Jacob A.
name: Li, Hui-Hua
name: Speicher, David W.
name: Fan, Ming-Hui
name: Majumdar, Sonali
name: Zhu, Qiang
name: Christofidou-Solomidou, Melpo
name: Madsen, Daniel H.
name: Puré, Ellen
name: Gulick, Dexter L.
name: Ra, Hyun-Jeong
name: Feghali-Bostwick, Carol
name: Bachovchin, William W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Idiopathic pulmonary fibrosis is a disease characterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2–4 years unless lung transplantation is performed. New effective therapies are clearly needed. Fibroblast activation protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients with idiopathic pulmonary fibrosis as well as in wound healing and cancer. We postulate that FAP is not only a marker of disease but influences the development of pulmonary fibrosis after lung injury. In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, we find increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice. Lung extracellular matrix analysis reveals accumulation of intermediate-sized collagen fragments in FAP-deficient mouse lungs, consistent with in vitro studies showing that FAP mediates ordered proteolytic processing of matrix metalloproteinase (MMP)-derived collagen cleavage products. FAP-mediated collagen processing leads to increased collagen internalization without altering expression of the endocytic collagen receptor, Endo180. Pharmacologic FAP inhibition decreases collagen internalization as expected. Conversely, restoration of FAP expression in the lungs of FAP-deficient mice decreases lung hydroxyproline content after intratracheal bleomycin to levels comparable with that of wild-type controls. Our findings indicate that FAP participates directly, in concert with MMPs, in collagen catabolism and clearance and is an important factor in resolving scar after injury and restoring lung homeostasis. Our study identifies FAP as a novel endogenous regulator of fibrosis and is the first to show FAP's protective effects in the lung.
title: Thoracic Medical Devices: A Pictorial Review
Creators: name: Tie, Han
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Cardiac
subject: Lung
subject: Cardiovascular system
subject: Plain radiographic studies
subject: Education
subject: Education and training

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: 1. To illustrate the radiological appearance and expected position of medical devices in the thorax which may not be frequently encountered in many hospitals and radiology practices. 2. To gain an understanding of the intended function of these...
Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions
Creators: name: Bandari, Shyam Kumar
name: Sanderson, Ralph D.
name: Purushothaman, Anurag
name: Brown, Elizabeth A.
name: Liu, Jian
name: Mobley, James A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Exosomes regulate cell behavior by binding to and delivering their cargo to target cells; however, the mechanisms mediating exosome-cell interactions are poorly understood. Heparan sulfates on target cell surfaces can act as receptors for exosome uptake, but the ligand for heparan sulfate on exosomes has not been identified. Using exosomes isolated from myeloma cell lines and from myeloma patients, we identify exosomal fibronectin as a key heparan sulfate-binding ligand and mediator of exosome-cell interactions. We discovered that heparan sulfate plays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on target cells it acts as a receptor for fibronectin. Removal of heparan sulfate from the exosome surface releases fibronectin and dramatically inhibits exosome-target cell interaction. Antibody specific for the Hep-II heparin-binding domain of fibronectin blocks exosome interaction with tumor cells or with marrow stromal cells. Regarding exosome function, fibronectin-mediated binding of exosomes to myeloma cells activated p38 and pERK signaling and expression of downstream target genes DKK1 and MMP-9, two molecules that promote myeloma progression. Antibody against fibronectin inhibited the ability of myeloma-derived exosomes to stimulate endothelial cell invasion. Heparin or heparin mimetics including Roneparstat, a modified heparin in phase I trials in myeloma patients, significantly inhibited exosome-cell interactions. These studies provide the first evidence that fibronectin binding to heparan sulfate mediates exosome-cell interactions, revealing a fundamental mechanism important for exosome-mediated cross-talk within tumor microenvironments. Moreover, these results imply that therapeutic disruption of fibronectin-heparan sulfate interactions will negatively impact myeloma tumor growth and progression.
Sonnenfleckenzeichnung Nr. 23.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.02.2008, 11:45, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 170.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.07.2008, 08:00, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 141.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.06.2008, 09:00, erstellt von Andrea Manna
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Perception of Bias Study 3A Meta Harm Preregistration
Creators: name: Bareket-Shavit, Carmelle
name: Schmader, Toni
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences

description: In this research we seek to better understand the effects of bias in its different forms. Specifically, we compare the experience of harm from unbiased behavior, implicit forms of biased behavior, and intentional forms of biased behavior. The full preregistration for this study is attached as a pdf file. This preregistration describes a follow-up study on perceptions of harm.
Distant set distinguishing edge colourings of graphs
Creators: name: Przybyło, Jakub
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C15

description: We consider the following extension of the concept of adjacent strong edge colourings of graphs without isolated edges. Two distinct vertices which are at distant at most $r$ in a graph are called $r$-adjacent. The least number of colours in a proper edge colouring of a graph $G$ such that the sets of colours met by any $r$-adjacent vertices in $G$ are distinct is called the $r$-adjacent strong chromatic index of $G$ and denoted by $χ'_{a,r}(G)$. It has been conjectured that $χ'_{a,1}(G)\leqΔ+2$ if $G$ is connected of maximum degree $Δ$ and non-isomorphic to $C_5$, while Hatami proved that there is a constant $C$, $C\leq 300$, such that $χ'_{a,1}(G)\leqΔ+C$ if $Δ>10^{20}$ [J. Combin. Theory Ser. B 95 (2005) 246--256]. We conjecture that a similar statement should hold for any $r$, i.e., that for each positive integer $r$ there exist constants $δ_0$ and $C$ such that $χ'_{a,r}(G) \leq Δ+C$ for every graph without an isolated edge and with minimum degree $δ\geq δ_0$, and argue that a lower bound on $δ$ is unavoidable in such a case (for $r>2$). Using the probabilistic method we prove such upper bound to hold for graphs with $δ\geq εΔ$, for every $r$ and any fixed $\varepsilon\in(0,1]$, i.e., in particular for regular graphs. We also support the conjecture by proving an upper bound $χ'_{a,r}(G) \leq (1+o(1))Δ$ for graphs with $δ\geq r+2$.
description: 17 pages
Primordial non-gaussianity from the bispectrum of 21-cm fluctuations in the dark ages
Creators: name: Muñoz, Julian B.
name: Ali-Haïmoud, Yacine
name: Kamionkowski, Marc
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: A measurement of primordial non-gaussianity will be of paramount importance to distinguish between different models of inflation. Cosmic microwave background (CMB) anisotropy observations have set unprecedented bounds on the non-gaussianity parameter f_NL but the interesting regime f_NL
description: 14 pages, 7 figures, published in PRD
Differences in Personal and Professional Tweets of Scholars
Creators: name: Bowman, Timothy D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Digital Libraries (cs.DL)
subject: FOS: Computer and information sciences

description: Purpose: This study shows that there were differences in the use of Twitter by professors at universities in the Association of American Universities (AAU). Affordance use differed between the personal and professional tweets of professors. Framing behaviors were described that could impact the interpretation of tweets by audience members. Design/methodology/approach: A three phase research design was used that included surveys of professors, categorization of tweets by Amazon's Mechanical Turk workers (i.e., turkers), and categorization of tweets by active professors on Twitter. Findings: There were significant differences found between professors that reported having a Twitter account, significant differences found between types of Twitter accounts (personal, professional, or both), and significant differences in the affordances used in personal and professional tweets. Framing behaviors were described that may assist altmetric researchers in distinguishing between personal and professional tweets. Research limitations/implications (if applicable): The study is limited by the sample population, survey instrument, low survey response rate, and low Cohen's kappa. Practical implications (if applicable): An overview of various affordances found in Twitter is provided and a novel use of Amazon's Mechanical Turk for the categorization of tweets is described that can be applied to future altmetric studies. Originality/value: This work utilizes a socio-technical framework integrating social and psychological theories to interpret results from the tweeting behavior of professors and the interpretation of tweets by workers in Amazon's Mechanical Turk.
Generation of coherent spin-wave modes in Yttrium Iron Garnet microdiscs by spin-orbit torque
Creators: name: Collet, Martin
name: De Milly, Xavier
name: D'Allivy-Kelly, Olivier
name: Naletov, Vladimir V.
name: Bernard, Rozenn
name: Bortolotti, Paolo
name: Demidov, Vladislav
name: Demokritov, Sergej
name: Prieto, Jose Luis
name: Muñoz, Manuel
name: Anane, Abdelmadjid
name: Cros, Vincent
name: De Loubens, Grégoire
name: Klein, Olivier
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin-orbit effects [1-4] have the potential of radically changing the field of spintronics by allowing transfer of spin angular momentum to a whole new class of materials. In a seminal letter to Nature [5], Kajiwara et al. showed that by depositing Platinum (Pt, a normal metal) on top of a 1.3 $μ$m thick Yttrium Iron Garnet (YIG, a magnetic insulator), one could effectively transfer spin angular momentum through the interface between these two different materials. The outstanding feature was the detection of auto-oscillation of the YIG when enough dc current was passed in the Pt. This finding has created a great excitement in the community for two reasons: first, one could control electronically the damping of insulators, which can offer improved properties compared to metals, and here YIG has the lowest damping known in nature; second, the damping compensation could be achieved on very large objects, a particularly relevant point for the field of magnonics [6,7] whose aim is to use spin-waves as carriers of information. However, the degree of coherence of the observed auto-oscillations has not been addressed in ref. [5]. In this work, we emphasize the key role of quasi-degenerate spin-wave modes, which increase the threshold current. This requires to reduce both the thickness and lateral size in order to reach full damping compensation [8] , and we show clear evidence of coherent spin-orbit torque induced auto-oscillation in micron-sized YIG discs of thickness 20 nm.
Sonnenfleckenzeichnung Nr. 156.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.07.2008, 11:30, erstellt von Sergio Cortesi
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 2008

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling
Creators: name: Dokholyan, Nikolay V.
name: Kota, Pradeep
name: Dang, Yan L.
name: Dagliyan, Onur
name: He, Hong
name: Shobair, Mahmoud
name: Stutts, M. Jackson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Sodium absorption in epithelial cells is rate-limited by the epithelial sodium channel (ENaC) activity in lung, kidney, and the distal colon. Pathophysiological conditions, such as cystic fibrosis and Liddle syndrome, result from water-electrolyte imbalance partly due to malfunction of ENaC regulation. Because the quaternary structure of ENaC is yet undetermined, the bases of pathologically linked mutations in ENaC subunits α, β, and γ are largely unknown. Here, we present a structural model of heterotetrameric ENaC α1βα2γ that is consistent with previous cross-linking results and site-directed mutagenesis experiments. By using this model, we show that the disease-causing mutation αW493R rewires structural dynamics of the intersubunit interfaces α1β and α2γ. Changes in dynamics can allosterically propagate to the channel gate. We demonstrate that cleavage of the γ-subunit, which is critical for full channel activation, does not mediate activation of ENaC by αW493R. Our molecular dynamics simulations led us to identify a channel-activating electrostatic interaction between α2Arg-493 and γGlu-348 at the α2γ interface. By neutralizing a sodium-binding acidic patch at the α1β interface, we reduced ENaC activation of αW493R by more than 2-fold. By combining homology modeling, molecular dynamics, cysteine cross-linking, and voltage clamp experiments, we propose a dynamics-driven model for the gain-of-function in ENaC by αW493R. Our integrated computational and experimental approach advances our understanding of structure, dynamics, and function of ENaC in its disease-causing state.
Predicting popularity of online videos using Support Vector Regression
Creators: name: Trzcinski, Tomasz
name: Rokita, Przemyslaw
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this work, we propose a regression method to predict the popularity of an online video based on temporal and visual cues. Our method uses Support Vector Regression with Gaussian Radial Basis Functions. We show that modelling popularity patterns with this approach provides higher and more stable prediction results, mainly thanks to the non-linearity character of the proposed method as well as its resistance against overfitting. We compare our method with the state of the art on datasets containing over 14,000 videos from YouTube and Facebook. Furthermore, we show that results obtained relying only on the early distribution patterns, can be improved by adding social and visual metadata.
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate
Creators: name: Cook, Jeanette G.
name: Tamir, Tigist Y.
name: Jacobs, Timothy M.
name: Vaziri, Cyrus
name: Harrison, Joseph S.
name: Goldfarb, Dennis
name: Siesser, Priscila F.
name: Matson, Jacob P.
name: Cloer, Erica W.
name: Major, Michael B.
name: Mulvaney, Kathleen M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identified. Because KEAP1 is altered in a number of human pathologies and has been proposed as a potential therapeutic target therein, we sought to better understand KEAP1 through systematic identification of its substrates. Toward this goal, we combined parallel affinity capture proteomics and candidate-based approaches. Substrate-trapping proteomics yielded NRF2 and the related transcription factor NRF1 as KEAP1 substrates. Our targeted investigation of KEAP1-interacting proteins revealed MCM3, an essential subunit of the replicative DNA helicase, as a new substrate. We show that MCM3 is ubiquitylated by the KEAP1-CUL3-RBX1 complex in cells and in vitro. Using ubiquitin remnant profiling, we identify the sites of KEAP1-dependent ubiquitylation in MCM3, and these sites are on predicted exposed surfaces of the MCM2–7 complex. Unexpectedly, we determined that KEAP1 does not regulate total MCM3 protein stability or subcellular localization. Our analysis of a KEAP1 targeting motif in MCM3 suggests that MCM3 is a point of direct contact between KEAP1 and the MCM hexamer. Moreover, KEAP1 associates with chromatin in a cell cycle-dependent fashion with kinetics similar to the MCM2–7 complex. KEAP1 is thus poised to affect MCM2–7 dynamics or function rather than MCM3 abundance. Together, these data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.
title: Comparing Vaginal Dose Reporting Using 2 Different Types of Standard Intra-Cavitary Applicators in Cervical Cancer Patients - Is There a Difference?
Creators: name: Tang, Johann
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Radiation therapy / Oncology
subject: MR
subject: Genital / Reproductive system female
subject: Radiotherapy techniques

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Traditionally, vaginal dose points are defined at vaginal source level during brachytherapy with no dose information to the entire vagina. Dose information to the mid and lower thirds of the vagina is lacking despite literature suggesting increased...
Moving point source model in EPISODE-CityChem
Creators: name: Pan, Kang
Publisher: name: Zenodo
Year: 2022
Subjects: shipping emission
air pollution
dispersion modelling
EPISODE-CityChem
moving point source model
Atmospheric pollutant

description: @20220831, topm() code in tspsrc.f90 is updated that when moving point is outside of simulation domain, stop calculate it. The source codes and data sets for the new moving point source (MPS) model used in EPISODE-CityChem v1.3 are provided in this link. More information can be found in "instruction.pdf". source_codes.zip: The source codes for MPS model and modified line source (LS) codes for shipping emission modelling simplified_1ship.zip: Input and output data sets for simplified study of shipping emission dispersion modelling with only 1 ship. simplified_44ship.zip: Input and output data sets for simplified study of shipping emission dispersion modelling with 44 ships. real_study.zip: Input and output data sets for real case study of shipping emission dispersion modelling
description: {"references": ["Development of a moving point source model for shipping emission dispersion modeling in EPISODE\u2013CityChem v1.3. https://doi.org/10.5194/gmd-14-4509-2021"]}
title: Single Institution Review of High Dose Rate Brachytherapy in the Management of Non-Melanoma Skin Cancers
Creators: name: Kaminski, Artur
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2016
Subjects: subject: Management
subject: Digital radiography
subject: Brachytherapy
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: To review the clinical outcomes and toxicity in all patients treated with high dose rate brachytherapy with definitive or palliative intent, in the management of non-melanoma skin cancers (squamous and basal cell...